id	sid	tid	token	lemma	pos
aiua-8854	1	1	cop+ed+fisse	cop+ed+fisse	NOUN
aiua-8854	1	2	2006	2006	NUM
aiua-8854	1	3	archivio	archivio	NOUN
aiua-8854	1	4	italiano	italiano	X
aiua-8854	1	5	di	di	X
aiua-8854	1	6	urologia	urologia	PROPN
aiua-8854	1	7	e	e	PROPN
aiua-8854	1	8	andrologia	andrologia	NOUN
aiua-8854	1	9	2020	2020	NUM
aiua-8854	1	10	;	;	PUNCT
aiua-8854	1	11	92	92	NUM
aiua-8854	1	12	,	,	PUNCT
aiua-8854	1	13	3196	3196	NUM
aiua-8854	1	14	case	case	NOUN
aiua-8854	1	15	report	report	VERB
aiua-8854	1	16	no	no	DET
aiua-8854	1	17	conflict	conflict	NOUN
aiua-8854	1	18	of	of	ADP
aiua-8854	1	19	interest	interest	NOUN
aiua-8854	1	20	declared	declare	VERB
aiua-8854	1	21	.	.	PUNCT
aiua-8854	2	1	doi	doi	NOUN
aiua-8854	2	2	:	:	PUNCT
aiua-8854	2	3	10.4081	10.4081	NUM
aiua-8854	2	4	/	/	SYM
aiua-8854	2	5	aiua.2020.3.196	aiua.2020.3.196	ADJ
aiua-8854	2	6	bone	bone	NOUN
aiua-8854	2	7	pain	pain	NOUN
aiua-8854	2	8	palliation	palliation	NOUN
aiua-8854	2	9	outcomes	outcome	NOUN
aiua-8854	2	10	and	and	CCONJ
aiua-8854	2	11	possibility	possibility	NOUN
aiua-8854	2	12	of	of	ADP
aiua-8854	2	13	radium-223	radium-223	NOUN
aiua-8854	2	14	re	re	NOUN
aiua-8854	2	15	-	-	NOUN
aiua-8854	2	16	treatment	treatment	NOUN
aiua-8854	2	17	in	in	ADP
aiua-8854	2	18	mcrpc	mcrpc	PROPN
aiua-8854	2	19	viviana	viviana	PROPN
aiua-8854	2	20	frantellizzi	frantellizzi	PROPN
aiua-8854	2	21	1	1	NUM
aiua-8854	2	22	,	,	PUNCT
aiua-8854	2	23	julia	julia	PROPN
aiua-8854	2	24	lazri	lazri	PROPN
aiua-8854	2	25	2	2	NUM
aiua-8854	2	26	,	,	PUNCT
aiua-8854	2	27	mariano	mariano	PROPN
aiua-8854	2	28	pontico	pontico	PROPN
aiua-8854	2	29	3	3	NUM
aiua-8854	2	30	,	,	PUNCT
aiua-8854	2	31	arianna	arianna	PROPN
aiua-8854	2	32	pani	pani	X
aiua-8854	2	33	4	4	NUM
aiua-8854	2	34	,	,	PUNCT
aiua-8854	2	35	giuseppe	giuseppe	PROPN
aiua-8854	2	36	de	de	PROPN
aiua-8854	2	37	vincentis	vincentis	PROPN
aiua-8854	2	38	2	2	NUM
aiua-8854	2	39	1	1	NUM
aiua-8854	2	40	department	department	NOUN
aiua-8854	2	41	of	of	ADP
aiua-8854	2	42	molecular	molecular	ADJ
aiua-8854	2	43	medicine	medicine	NOUN
aiua-8854	2	44	,	,	PUNCT
aiua-8854	2	45	sapienza	sapienza	PROPN
aiua-8854	2	46	university	university	PROPN
aiua-8854	2	47	of	of	ADP
aiua-8854	2	48	rome	rome	PROPN
aiua-8854	2	49	,	,	PUNCT
aiua-8854	2	50	rome	rome	PROPN
aiua-8854	2	51	,	,	PUNCT
aiua-8854	2	52	italy	italy	PROPN
aiua-8854	2	53	;	;	PUNCT
aiua-8854	2	54	2	2	NUM
aiua-8854	2	55	department	department	NOUN
aiua-8854	2	56	of	of	ADP
aiua-8854	2	57	radiological	radiological	ADJ
aiua-8854	2	58	sciences	science	NOUN
aiua-8854	2	59	,	,	PUNCT
aiua-8854	2	60	oncology	oncology	NOUN
aiua-8854	2	61	and	and	CCONJ
aiua-8854	2	62	anatomical	anatomical	ADJ
aiua-8854	2	63	pathology	pathology	NOUN
aiua-8854	2	64	,	,	PUNCT
aiua-8854	2	65	sapienza	sapienza	PROPN
aiua-8854	2	66	university	university	PROPN
aiua-8854	2	67	of	of	ADP
aiua-8854	2	68	rome	rome	PROPN
aiua-8854	2	69	,	,	PUNCT
aiua-8854	2	70	rome	rome	PROPN
aiua-8854	2	71	,	,	PUNCT
aiua-8854	2	72	italy	italy	PROPN
aiua-8854	2	73	;	;	PUNCT
aiua-8854	2	74	3	3	NUM
aiua-8854	2	75	ph.d	ph.d	PROPN
aiua-8854	2	76	.	.	PROPN
aiua-8854	2	77	,	,	PUNCT
aiua-8854	2	78	program	program	NOUN
aiua-8854	2	79	in	in	ADP
aiua-8854	2	80	morphogenesis	morphogenesis	NOUN
aiua-8854	2	81	&	&	CCONJ
aiua-8854	2	82	tissue	tissue	NOUN
aiua-8854	2	83	engineering	engineering	NOUN
aiua-8854	2	84	,	,	PUNCT
aiua-8854	2	85	“	"	PUNCT
aiua-8854	2	86	sapienza	sapienza	ADJ
aiua-8854	2	87	”	"	PUNCT
aiua-8854	2	88	university	university	PROPN
aiua-8854	2	89	of	of	ADP
aiua-8854	2	90	rome	rome	PROPN
aiua-8854	2	91	,	,	PUNCT
aiua-8854	2	92	rome	rome	PROPN
aiua-8854	2	93	,	,	PUNCT
aiua-8854	2	94	italy	italy	PROPN
aiua-8854	2	95	;	;	PUNCT
aiua-8854	2	96	4	4	NUM
aiua-8854	2	97	clinical	clinical	ADJ
aiua-8854	2	98	pharmacology	pharmacology	NOUN
aiua-8854	2	99	and	and	CCONJ
aiua-8854	2	100	toxicology	toxicology	NOUN
aiua-8854	2	101	,	,	PUNCT
aiua-8854	2	102	university	university	PROPN
aiua-8854	2	103	of	of	ADP
aiua-8854	2	104	milan	milan	PROPN
aiua-8854	2	105	,	,	PUNCT
aiua-8854	2	106	milan	milan	PROPN
aiua-8854	2	107	,	,	PUNCT
aiua-8854	2	108	italy	italy	PROPN
aiua-8854	2	109	.	.	PUNCT
aiua-8854	3	1	objective	objective	NOUN
aiua-8854	3	2	.	.	PUNCT
aiua-8854	4	1	bone	bone	NOUN
aiua-8854	4	2	secondary	secondary	ADJ
aiua-8854	4	3	localizations	localization	NOUN
aiua-8854	4	4	from	from	ADP
aiua-8854	4	5	metastatic	metastatic	ADJ
aiua-8854	4	6	castration	castration	NOUN
aiua-8854	4	7	-	-	PUNCT
aiua-8854	4	8	resistant	resistant	ADJ
aiua-8854	4	9	prostate	prostate	NOUN
aiua-8854	4	10	cancer	cancer	NOUN
aiua-8854	4	11	are	be	AUX
aiua-8854	4	12	associated	associate	VERB
aiua-8854	4	13	with	with	ADP
aiua-8854	4	14	an	an	DET
aiua-8854	4	15	increase	increase	NOUN
aiua-8854	4	16	in	in	ADP
aiua-8854	4	17	mortality	mortality	NOUN
aiua-8854	4	18	and	and	CCONJ
aiua-8854	4	19	a	a	DET
aiua-8854	4	20	reduction	reduction	NOUN
aiua-8854	4	21	in	in	ADP
aiua-8854	4	22	the	the	DET
aiua-8854	4	23	patient	patient	NOUN
aiua-8854	4	24	’s	’s	PART
aiua-8854	4	25	quality	quality	NOUN
aiua-8854	4	26	of	of	ADP
aiua-8854	4	27	life	life	NOUN
aiua-8854	4	28	.	.	PUNCT
aiua-8854	5	1	radium-223	radium-223	NOUN
aiua-8854	5	2	is	be	AUX
aiua-8854	5	3	a	a	DET
aiua-8854	5	4	targeted	target	VERB
aiua-8854	5	5	alpha	alpha	NOUN
aiua-8854	5	6	-	-	PUNCT
aiua-8854	5	7	therapy	therapy	NOUN
aiua-8854	5	8	approved	approve	VERB
aiua-8854	5	9	for	for	ADP
aiua-8854	5	10	the	the	DET
aiua-8854	5	11	treatment	treatment	NOUN
aiua-8854	5	12	of	of	ADP
aiua-8854	5	13	mcrpc	mcrpc	NOUN
aiua-8854	5	14	(	(	PUNCT
aiua-8854	5	15	metastatic	metastatic	ADJ
aiua-8854	5	16	castration	castration	NOUN
aiua-8854	5	17	resistant	resistant	ADJ
aiua-8854	5	18	prostate	prostate	NOUN
aiua-8854	5	19	cancer	cancer	NOUN
aiua-8854	5	20	)	)	PUNCT
aiua-8854	5	21	patients	patient	NOUN
aiua-8854	5	22	with	with	ADP
aiua-8854	5	23	symptomatic	symptomatic	ADJ
aiua-8854	5	24	bone	bone	NOUN
aiua-8854	5	25	metastases	metastasis	NOUN
aiua-8854	5	26	.	.	PUNCT
aiua-8854	6	1	to	to	ADP
aiua-8854	6	2	our	our	PRON
aiua-8854	6	3	knowledge	knowledge	NOUN
aiua-8854	6	4	,	,	PUNCT
aiua-8854	6	5	no	no	DET
aiua-8854	6	6	previous	previous	ADJ
aiua-8854	6	7	study	study	NOUN
aiua-8854	6	8	has	have	AUX
aiua-8854	6	9	been	be	AUX
aiua-8854	6	10	performed	perform	VERB
aiua-8854	6	11	assessing	assess	VERB
aiua-8854	6	12	the	the	DET
aiua-8854	6	13	bone	bone	NOUN
aiua-8854	6	14	pain	pain	NOUN
aiua-8854	6	15	palliation	palliation	NOUN
aiua-8854	6	16	outcomes	outcome	NOUN
aiua-8854	6	17	following	follow	VERB
aiua-8854	6	18	radium-223	radium-223	NOUN
aiua-8854	6	19	therapy	therapy	NOUN
aiua-8854	6	20	.	.	PUNCT
aiua-8854	7	1	materials	material	NOUN
aiua-8854	7	2	and	and	CCONJ
aiua-8854	7	3	methods	method	NOUN
aiua-8854	7	4	.	.	PUNCT
aiua-8854	8	1	a	a	DET
aiua-8854	8	2	mcrpc	mcrpc	NOUN
aiua-8854	8	3	patient	patient	ADJ
aiua-8854	8	4	with	with	ADP
aiua-8854	8	5	symptomatic	symptomatic	ADJ
aiua-8854	8	6	bone	bone	NOUN
aiua-8854	8	7	localizations	localization	NOUN
aiua-8854	8	8	and	and	CCONJ
aiua-8854	8	9	relevant	relevant	ADJ
aiua-8854	8	10	bone	bone	NOUN
aiua-8854	8	11	pain	pain	NOUN
aiua-8854	8	12	symptoms	symptom	NOUN
aiua-8854	8	13	has	have	AUX
aiua-8854	8	14	been	be	AUX
aiua-8854	8	15	subjected	subject	VERB
aiua-8854	8	16	to	to	AUX
aiua-8854	8	17	radium-223	radium-223	VERB
aiua-8854	8	18	treatment	treatment	NOUN
aiua-8854	8	19	.	.	PUNCT
aiua-8854	9	1	pain	pain	NOUN
aiua-8854	9	2	was	be	AUX
aiua-8854	9	3	assessed	assess	VERB
aiua-8854	9	4	over	over	ADP
aiua-8854	9	5	time	time	NOUN
aiua-8854	9	6	from	from	ADP
aiua-8854	9	7	the	the	DET
aiua-8854	9	8	first	first	ADJ
aiua-8854	9	9	administration	administration	NOUN
aiua-8854	9	10	of	of	ADP
aiua-8854	9	11	radium-223	radium-223	NOUN
aiua-8854	9	12	to	to	PART
aiua-8854	9	13	follow	follow	VERB
aiua-8854	9	14	-	-	PUNCT
aiua-8854	9	15	up	up	NOUN
aiua-8854	9	16	.	.	PUNCT
aiua-8854	10	1	results	result	NOUN
aiua-8854	10	2	.	.	PUNCT
aiua-8854	11	1	after	after	ADP
aiua-8854	11	2	radium-223	radium-223	NOUN
aiua-8854	11	3	treatment	treatment	NOUN
aiua-8854	11	4	,	,	PUNCT
aiua-8854	11	5	patient	patient	NOUN
aiua-8854	11	6	showed	show	VERB
aiua-8854	11	7	a	a	DET
aiua-8854	11	8	significant	significant	ADJ
aiua-8854	11	9	bpi	bpi	NOUN
aiua-8854	11	10	(	(	PUNCT
aiua-8854	11	11	brief	brief	ADJ
aiua-8854	11	12	pain	pain	NOUN
aiua-8854	11	13	inventory	inventory	NOUN
aiua-8854	11	14	)	)	PUNCT
aiua-8854	11	15	decline	decline	VERB
aiua-8854	11	16	from	from	ADP
aiua-8854	11	17	7	7	NUM
aiua-8854	11	18	to	to	ADP
aiua-8854	11	19	4	4	NUM
aiua-8854	11	20	and	and	CCONJ
aiua-8854	11	21	a	a	DET
aiua-8854	11	22	concomitant	concomitant	ADJ
aiua-8854	11	23	partial	partial	ADJ
aiua-8854	11	24	regression	regression	NOUN
aiua-8854	11	25	of	of	ADP
aiua-8854	11	26	multiple	multiple	ADJ
aiua-8854	11	27	bone	bone	NOUN
aiua-8854	11	28	hot	hot	ADJ
aiua-8854	11	29	spots	spot	NOUN
aiua-8854	11	30	in	in	ADP
aiua-8854	11	31	the	the	DET
aiua-8854	11	32	bone	bone	NOUN
aiua-8854	11	33	scan	scan	NOUN
aiua-8854	11	34	exam	exam	NOUN
aiua-8854	11	35	.	.	PUNCT
aiua-8854	12	1	three	three	NUM
aiua-8854	12	2	months	month	NOUN
aiua-8854	12	3	after	after	ADP
aiua-8854	12	4	the	the	DET
aiua-8854	12	5	last	last	ADJ
aiua-8854	12	6	infusion	infusion	NOUN
aiua-8854	12	7	of	of	ADP
aiua-8854	12	8	radium-223	radium-223	NOUN
aiua-8854	12	9	,	,	PUNCT
aiua-8854	12	10	further	further	PROPN
aiua-8854	12	11	bpi	bpi	PROPN
aiua-8854	12	12	decline	decline	NOUN
aiua-8854	12	13	(	(	PUNCT
aiua-8854	12	14	from	from	ADP
aiua-8854	12	15	4	4	NUM
aiua-8854	12	16	to	to	PART
aiua-8854	12	17	2	2	NUM
aiua-8854	12	18	)	)	PUNCT
aiua-8854	12	19	with	with	ADP
aiua-8854	12	20	bone	bone	NOUN
aiua-8854	12	21	scan	scan	NOUN
aiua-8854	12	22	depicting	depict	VERB
aiua-8854	12	23	stable	stable	ADJ
aiua-8854	12	24	disease	disease	NOUN
aiua-8854	12	25	was	be	AUX
aiua-8854	12	26	observed	observe	VERB
aiua-8854	12	27	.	.	PUNCT
aiua-8854	13	1	however	however	ADV
aiua-8854	13	2	,	,	PUNCT
aiua-8854	13	3	after	after	ADP
aiua-8854	13	4	6	6	NUM
aiua-8854	13	5	months	month	NOUN
aiua-8854	13	6	from	from	ADP
aiua-8854	13	7	radium-223	radium-223	NOUN
aiua-8854	13	8	treatment	treatment	NOUN
aiua-8854	13	9	end	end	NOUN
aiua-8854	13	10	,	,	PUNCT
aiua-8854	13	11	bpi	bpi	PROPN
aiua-8854	13	12	increased	increase	VERB
aiua-8854	13	13	from	from	ADP
aiua-8854	13	14	2	2	NUM
aiua-8854	13	15	to	to	ADP
aiua-8854	13	16	10	10	NUM
aiua-8854	13	17	.	.	PUNCT
aiua-8854	14	1	conclusions	conclusion	NOUN
aiua-8854	14	2	.	.	PUNCT
aiua-8854	15	1	taking	take	VERB
aiua-8854	15	2	into	into	ADP
aiua-8854	15	3	account	account	NOUN
aiua-8854	15	4	the	the	DET
aiua-8854	15	5	effectiveness	effectiveness	NOUN
aiua-8854	15	6	on	on	ADP
aiua-8854	15	7	bone	bone	NOUN
aiua-8854	15	8	pain	pain	NOUN
aiua-8854	15	9	relief	relief	NOUN
aiua-8854	15	10	and	and	CCONJ
aiua-8854	15	11	the	the	DET
aiua-8854	15	12	low	low	ADJ
aiua-8854	15	13	toxicity	toxicity	NOUN
aiua-8854	15	14	profile	profile	NOUN
aiua-8854	15	15	showed	show	VERB
aiua-8854	15	16	by	by	ADP
aiua-8854	15	17	radium-223	radium-223	NOUN
aiua-8854	15	18	treatment	treatment	NOUN
aiua-8854	15	19	,	,	PUNCT
aiua-8854	15	20	we	we	PRON
aiua-8854	15	21	encourage	encourage	VERB
aiua-8854	15	22	further	further	ADJ
aiua-8854	15	23	analysis	analysis	NOUN
aiua-8854	15	24	on	on	ADP
aiua-8854	15	25	large	large	ADJ
aiua-8854	15	26	cohort	cohort	NOUN
aiua-8854	15	27	to	to	PART
aiua-8854	15	28	investigate	investigate	VERB
aiua-8854	15	29	the	the	DET
aiua-8854	15	30	clinical	clinical	ADJ
aiua-8854	15	31	outcome	outcome	NOUN
aiua-8854	15	32	after	after	ADP
aiua-8854	15	33	radium-223	radium-223	NOUN
aiua-8854	15	34	treatment	treatment	NOUN
aiua-8854	15	35	,	,	PUNCT
aiua-8854	15	36	in	in	ADP
aiua-8854	15	37	terms	term	NOUN
aiua-8854	15	38	of	of	ADP
aiua-8854	15	39	bone	bone	NOUN
aiua-8854	15	40	pain	pain	NOUN
aiua-8854	15	41	palliation	palliation	NOUN
aiua-8854	15	42	,	,	PUNCT
aiua-8854	15	43	together	together	ADV
aiua-8854	15	44	with	with	ADP
aiua-8854	15	45	the	the	DET
aiua-8854	15	46	possibility	possibility	NOUN
aiua-8854	15	47	of	of	ADP
aiua-8854	15	48	radium-223	radium-223	NOUN
aiua-8854	15	49	re	re	NOUN
aiua-8854	15	50	-	-	NOUN
aiua-8854	15	51	treatment	treatment	NOUN
aiua-8854	15	52	in	in	ADP
aiua-8854	15	53	selected	select	VERB
aiua-8854	15	54	patients	patient	NOUN
aiua-8854	15	55	..	..	PUNCT
aiua-8854	15	56	key	key	ADJ
aiua-8854	15	57	words	word	NOUN
aiua-8854	15	58	:	:	PUNCT
aiua-8854	15	59	radium-223	radium-223	NOUN
aiua-8854	15	60	dichloride	dichloride	NOUN
aiua-8854	15	61	;	;	PUNCT
aiua-8854	15	62	bone	bone	NOUN
aiua-8854	15	63	pain	pain	NOUN
aiua-8854	15	64	;	;	PUNCT
aiua-8854	15	65	palliative	palliative	ADJ
aiua-8854	15	66	treatment	treatment	NOUN
aiua-8854	15	67	;	;	PUNCT
aiua-8854	15	68	mcrpc	mcrpc	PROPN
aiua-8854	15	69	.	.	PUNCT
aiua-8854	16	1	submitted	submit	VERB
aiua-8854	16	2	28	28	NUM
aiua-8854	16	3	january	january	PROPN
aiua-8854	16	4	2020	2020	NUM
aiua-8854	16	5	;	;	PUNCT
aiua-8854	16	6	accepted	accept	VERB
aiua-8854	16	7	18	18	NUM
aiua-8854	16	8	february	february	NOUN
aiua-8854	16	9	2020	2020	NUM
aiua-8854	16	10	summary	summary	NOUN
aiua-8854	16	11	introduction	introduction	NOUN
aiua-8854	16	12	prostate	prostate	NOUN
aiua-8854	16	13	cancer	cancer	NOUN
aiua-8854	16	14	(	(	PUNCT
aiua-8854	16	15	pca	pca	PROPN
aiua-8854	16	16	)	)	PUNCT
aiua-8854	16	17	in	in	ADP
aiua-8854	16	18	men	man	NOUN
aiua-8854	16	19	worldwide	worldwide	ADV
aiua-8854	16	20	is	be	AUX
aiua-8854	16	21	the	the	DET
aiua-8854	16	22	second	second	ADJ
aiua-8854	16	23	most	most	ADV
aiua-8854	16	24	common	common	ADJ
aiua-8854	16	25	cancer	cancer	NOUN
aiua-8854	16	26	(	(	PUNCT
aiua-8854	16	27	1	1	NUM
aiua-8854	16	28	,	,	PUNCT
aiua-8854	16	29	2	2	NUM
aiua-8854	16	30	)	)	PUNCT
aiua-8854	16	31	.	.	PUNCT
aiua-8854	17	1	most	most	ADJ
aiua-8854	17	2	subjects	subject	NOUN
aiua-8854	17	3	with	with	ADP
aiua-8854	17	4	metastatic	metastatic	ADJ
aiua-8854	17	5	pca	pca	NOUN
aiua-8854	17	6	,	,	PUNCT
aiua-8854	17	7	following	follow	VERB
aiua-8854	17	8	a	a	DET
aiua-8854	17	9	median	median	NOUN
aiua-8854	17	10	of	of	ADP
aiua-8854	17	11	18	18	NUM
aiua-8854	17	12	-	-	SYM
aiua-8854	17	13	24	24	NUM
aiua-8854	17	14	months	month	NOUN
aiua-8854	17	15	of	of	ADP
aiua-8854	17	16	endocrine	endocrine	NOUN
aiua-8854	17	17	therapy	therapy	NOUN
aiua-8854	17	18	,	,	PUNCT
aiua-8854	17	19	no	no	ADV
aiua-8854	17	20	longer	long	ADV
aiua-8854	17	21	respond	respond	VERB
aiua-8854	17	22	to	to	ADP
aiua-8854	17	23	traditional	traditional	ADJ
aiua-8854	17	24	androgen	androgen	NOUN
aiua-8854	17	25	deprivation	deprivation	NOUN
aiua-8854	17	26	therapy	therapy	NOUN
aiua-8854	17	27	(	(	PUNCT
aiua-8854	17	28	adt	adt	NOUN
aiua-8854	17	29	)	)	PUNCT
aiua-8854	17	30	(	(	PUNCT
aiua-8854	17	31	3	3	NUM
aiua-8854	17	32	,	,	PUNCT
aiua-8854	17	33	4	4	NUM
aiua-8854	17	34	)	)	PUNCT
aiua-8854	17	35	and	and	CCONJ
aiua-8854	17	36	are	be	AUX
aiua-8854	17	37	categorized	categorize	VERB
aiua-8854	17	38	as	as	ADP
aiua-8854	17	39	castration	castration	NOUN
aiua-8854	17	40	-	-	PUNCT
aiua-8854	17	41	resistant	resistant	ADJ
aiua-8854	17	42	prostate	prostate	NOUN
aiua-8854	17	43	cancer	cancer	NOUN
aiua-8854	17	44	(	(	PUNCT
aiua-8854	17	45	crpc	crpc	ADJ
aiua-8854	17	46	)	)	PUNCT
aiua-8854	17	47	,	,	PUNCT
aiua-8854	17	48	leading	lead	VERB
aiua-8854	17	49	to	to	ADP
aiua-8854	17	50	disease	disease	NOUN
aiua-8854	17	51	progression	progression	NOUN
aiua-8854	17	52	(	(	PUNCT
aiua-8854	17	53	5	5	NUM
aiua-8854	17	54	,	,	PUNCT
aiua-8854	17	55	6	6	NUM
aiua-8854	17	56	)	)	PUNCT
aiua-8854	17	57	.	.	PUNCT
aiua-8854	18	1	crpc	crpc	PROPN
aiua-8854	18	2	disease	disease	NOUN
aiua-8854	18	3	progression	progression	NOUN
aiua-8854	18	4	is	be	AUX
aiua-8854	18	5	characterized	characterize	VERB
aiua-8854	18	6	by	by	ADP
aiua-8854	18	7	the	the	DET
aiua-8854	18	8	presence	presence	NOUN
aiua-8854	18	9	of	of	ADP
aiua-8854	18	10	pain	pain	NOUN
aiua-8854	18	11	-	-	PUNCT
aiua-8854	18	12	inducing	induce	VERB
aiua-8854	18	13	bone	bone	NOUN
aiua-8854	18	14	metastases	metastasis	NOUN
aiua-8854	18	15	(	(	PUNCT
aiua-8854	18	16	90	90	NUM
aiua-8854	18	17	%	%	NOUN
aiua-8854	18	18	of	of	ADP
aiua-8854	18	19	patients	patient	NOUN
aiua-8854	18	20	)	)	PUNCT
aiua-8854	18	21	,	,	PUNCT
aiua-8854	18	22	with	with	ADP
aiua-8854	18	23	the	the	DET
aiua-8854	18	24	increase	increase	NOUN
aiua-8854	18	25	in	in	ADP
aiua-8854	18	26	total	total	ADJ
aiua-8854	18	27	alkaline	alkaline	NOUN
aiua-8854	18	28	phosphatase	phosphatase	NOUN
aiua-8854	18	29	(	(	PUNCT
aiua-8854	18	30	talp	talp	NOUN
aiua-8854	18	31	)	)	PUNCT
aiua-8854	18	32	and	and	CCONJ
aiua-8854	18	33	prostate	prostate	NOUN
aiua-8854	18	34	-	-	PUNCT
aiua-8854	18	35	specific	specific	ADJ
aiua-8854	18	36	antigen	antigen	NOUN
aiua-8854	18	37	(	(	PUNCT
aiua-8854	18	38	psa	psa	NOUN
aiua-8854	18	39	)	)	PUNCT
aiua-8854	18	40	levels	level	NOUN
aiua-8854	18	41	(	(	PUNCT
aiua-8854	18	42	7	7	NUM
aiua-8854	18	43	,	,	PUNCT
aiua-8854	18	44	8)	8)	NUM
aiua-8854	18	45	.	.	PUNCT
aiua-8854	19	1	the	the	DET
aiua-8854	19	2	development	development	NOUN
aiua-8854	19	3	of	of	ADP
aiua-8854	19	4	bone	bone	NOUN
aiua-8854	19	5	metastases	metastasis	NOUN
aiua-8854	19	6	is	be	AUX
aiua-8854	19	7	associated	associate	VERB
aiua-8854	19	8	with	with	ADP
aiua-8854	19	9	an	an	DET
aiua-8854	19	10	increase	increase	NOUN
aiua-8854	19	11	in	in	ADP
aiua-8854	19	12	mortality	mortality	NOUN
aiua-8854	19	13	and	and	CCONJ
aiua-8854	19	14	a	a	DET
aiua-8854	19	15	reduction	reduction	NOUN
aiua-8854	19	16	in	in	ADP
aiua-8854	19	17	the	the	DET
aiua-8854	19	18	patient	patient	NOUN
aiua-8854	19	19	’s	’s	PART
aiua-8854	19	20	health	health	NOUN
aiua-8854	19	21	-	-	PUNCT
aiua-8854	19	22	related	relate	VERB
aiua-8854	19	23	quality	quality	NOUN
aiua-8854	19	24	of	of	ADP
aiua-8854	19	25	life	life	NOUN
aiua-8854	19	26	(	(	PUNCT
aiua-8854	19	27	qol	qol	NOUN
aiua-8854	19	28	)	)	PUNCT
aiua-8854	19	29	(	(	PUNCT
aiua-8854	19	30	9	9	NUM
aiua-8854	19	31	-	-	SYM
aiua-8854	19	32	11	11	NUM
aiua-8854	19	33	)	)	PUNCT
aiua-8854	19	34	.	.	PUNCT
aiua-8854	20	1	treatment	treatment	NOUN
aiua-8854	20	2	options	option	NOUN
aiua-8854	20	3	for	for	ADP
aiua-8854	20	4	metastatic	metastatic	ADJ
aiua-8854	20	5	crpc	crpc	PROPN
aiua-8854	20	6	(	(	PUNCT
aiua-8854	20	7	mcrpc	mcrpc	NOUN
aiua-8854	20	8	)	)	PUNCT
aiua-8854	20	9	have	have	AUX
aiua-8854	20	10	recently	recently	ADV
aiua-8854	20	11	and	and	CCONJ
aiua-8854	20	12	include	include	VERB
aiua-8854	20	13	cytotoxic	cytotoxic	ADJ
aiua-8854	20	14	therapy	therapy	NOUN
aiua-8854	20	15	(	(	PUNCT
aiua-8854	20	16	e.g.	e.g.	ADV
aiua-8854	20	17	,	,	PUNCT
aiua-8854	20	18	docetaxel	docetaxel	NOUN
aiua-8854	20	19	,	,	PUNCT
aiua-8854	20	20	cabazitaxel	cabazitaxel	PROPN
aiua-8854	20	21	)	)	PUNCT
aiua-8854	20	22	,	,	PUNCT
aiua-8854	20	23	immunotherapy	immunotherapy	NOUN
aiua-8854	20	24	,	,	PUNCT
aiua-8854	20	25	oral	oral	ADJ
aiua-8854	20	26	hormonal	hormonal	ADJ
aiua-8854	20	27	therapies	therapy	NOUN
aiua-8854	20	28	targeting	target	VERB
aiua-8854	20	29	the	the	DET
aiua-8854	20	30	androgen	androgen	NOUN
aiua-8854	20	31	receptor	receptor	NOUN
aiua-8854	20	32	axis	axis	NOUN
aiua-8854	20	33	(	(	PUNCT
aiua-8854	20	34	e.g.	e.g.	ADV
aiua-8854	20	35	,	,	PUNCT
aiua-8854	20	36	enzalutamide	enzalutamide	ADV
aiua-8854	20	37	and	and	CCONJ
aiua-8854	20	38	abiraterone	abiraterone	NOUN
aiua-8854	20	39	)	)	PUNCT
aiua-8854	20	40	,	,	PUNCT
aiua-8854	20	41	bone	bone	NOUN
aiua-8854	20	42	health	health	NOUN
aiua-8854	20	43	agents	agent	NOUN
aiua-8854	20	44	(	(	PUNCT
aiua-8854	20	45	e.g.	e.g.	ADV
aiua-8854	20	46	,	,	PUNCT
aiua-8854	20	47	denosumab	denosumab	NOUN
aiua-8854	20	48	and	and	CCONJ
aiua-8854	20	49	zoledronic	zoledronic	ADJ
aiua-8854	20	50	acid	acid	NOUN
aiua-8854	20	51	)	)	PUNCT
aiua-8854	20	52	and	and	CCONJ
aiua-8854	20	53	targeted	target	VERB
aiua-8854	20	54	alpha	alpha	NOUN
aiua-8854	20	55	-	-	PUNCT
aiua-8854	20	56	therapy	therapy	NOUN
aiua-8854	20	57	(	(	PUNCT
aiua-8854	20	58	radium-223	radium-223	NOUN
aiua-8854	20	59	dichloride	dichloride	NOUN
aiua-8854	20	60	)	)	PUNCT
aiua-8854	20	61	(	(	PUNCT
aiua-8854	20	62	12	12	NUM
aiua-8854	20	63	-	-	SYM
aiua-8854	20	64	14	14	NUM
aiua-8854	20	65	)	)	PUNCT
aiua-8854	20	66	.	.	PUNCT
aiua-8854	21	1	radium223	radium223	PROPN
aiua-8854	21	2	has	have	AUX
aiua-8854	21	3	been	be	AUX
aiua-8854	21	4	approved	approve	VERB
aiua-8854	21	5	for	for	ADP
aiua-8854	21	6	the	the	DET
aiua-8854	21	7	treatment	treatment	NOUN
aiua-8854	21	8	of	of	ADP
aiua-8854	21	9	patients	patient	NOUN
aiua-8854	21	10	with	with	ADP
aiua-8854	21	11	mcrpc	mcrpc	PROPN
aiua-8854	21	12	with	with	ADP
aiua-8854	21	13	symptomatic	symptomatic	ADJ
aiua-8854	21	14	bone	bone	NOUN
aiua-8854	21	15	metastases	metastasis	NOUN
aiua-8854	21	16	and	and	CCONJ
aiua-8854	21	17	no	no	DET
aiua-8854	21	18	known	know	VERB
aiua-8854	21	19	visceral	visceral	ADJ
aiua-8854	21	20	metastatic	metastatic	ADJ
aiua-8854	21	21	disease	disease	NOUN
aiua-8854	21	22	(	(	PUNCT
aiua-8854	21	23	15	15	NUM
aiua-8854	21	24	)	)	PUNCT
aiua-8854	21	25	.	.	PUNCT
aiua-8854	22	1	this	this	DET
aiua-8854	22	2	radiopharmaceutical	radiopharmaceutical	ADJ
aiua-8854	22	3	have	have	VERB
aiua-8854	22	4	a	a	DET
aiua-8854	22	5	dual	dual	ADJ
aiua-8854	22	6	mechanism	mechanism	NOUN
aiua-8854	22	7	of	of	ADP
aiua-8854	22	8	action	action	NOUN
aiua-8854	22	9	,	,	PUNCT
aiua-8854	22	10	destroying	destroy	VERB
aiua-8854	22	11	bone	bone	NOUN
aiua-8854	22	12	-	-	PUNCT
aiua-8854	22	13	metastatic	metastatic	ADJ
aiua-8854	22	14	cancer	cancer	NOUN
aiua-8854	22	15	cells	cell	NOUN
aiua-8854	22	16	and	and	CCONJ
aiua-8854	22	17	affecting	affect	VERB
aiua-8854	22	18	tumor	tumor	NOUN
aiua-8854	22	19	-	-	PUNCT
aiua-8854	22	20	induced	induce	VERB
aiua-8854	22	21	pathological	pathological	ADJ
aiua-8854	22	22	bone	bone	NOUN
aiua-8854	22	23	activity	activity	NOUN
aiua-8854	22	24	(	(	PUNCT
aiua-8854	22	25	16	16	NUM
aiua-8854	22	26	)	)	PUNCT
aiua-8854	22	27	.	.	PUNCT
aiua-8854	23	1	currently	currently	ADV
aiua-8854	23	2	,	,	PUNCT
aiua-8854	23	3	radium-223	radium-223	NOUN
aiua-8854	23	4	is	be	AUX
aiua-8854	23	5	approved	approve	VERB
aiua-8854	23	6	as	as	ADP
aiua-8854	23	7	monotherapy	monotherapy	NOUN
aiua-8854	23	8	or	or	CCONJ
aiua-8854	23	9	in	in	ADP
aiua-8854	23	10	combination	combination	NOUN
aiua-8854	23	11	with	with	ADP
aiua-8854	23	12	a	a	DET
aiua-8854	23	13	luteinizing	luteinize	VERB
aiua-8854	23	14	hormone	hormone	NOUN
aiua-8854	23	15	-	-	PUNCT
aiua-8854	23	16	releasing	release	VERB
aiua-8854	23	17	hormone	hormone	NOUN
aiua-8854	23	18	(	(	PUNCT
aiua-8854	23	19	lhrh	lhrh	PROPN
aiua-8854	23	20	)	)	PUNCT
aiua-8854	23	21	analogue	analogue	NOUN
aiua-8854	23	22	for	for	ADP
aiua-8854	23	23	the	the	DET
aiua-8854	23	24	treatment	treatment	NOUN
aiua-8854	23	25	of	of	ADP
aiua-8854	23	26	adult	adult	NOUN
aiua-8854	23	27	patients	patient	NOUN
aiua-8854	23	28	with	with	ADP
aiua-8854	23	29	mcrpc	mcrpc	NOUN
aiua-8854	23	30	who	who	PRON
aiua-8854	23	31	are	be	AUX
aiua-8854	23	32	in	in	ADP
aiua-8854	23	33	progression	progression	NOUN
aiua-8854	23	34	after	after	ADP
aiua-8854	23	35	at	at	ADP
aiua-8854	23	36	least	least	ADV
aiua-8854	23	37	two	two	NUM
aiua-8854	23	38	prior	prior	ADJ
aiua-8854	23	39	lines	line	NOUN
aiua-8854	23	40	of	of	ADP
aiua-8854	23	41	systemic	systemic	ADJ
aiua-8854	23	42	therapy	therapy	NOUN
aiua-8854	23	43	(	(	PUNCT
aiua-8854	23	44	other	other	ADJ
aiua-8854	23	45	than	than	ADP
aiua-8854	23	46	lhrh	lhrh	ADJ
aiua-8854	23	47	analogues	analogue	NOUN
aiua-8854	23	48	)	)	PUNCT
aiua-8854	23	49	,	,	PUNCT
aiua-8854	23	50	or	or	CCONJ
aiua-8854	23	51	ineligible	ineligible	ADJ
aiua-8854	23	52	for	for	ADP
aiua-8854	23	53	any	any	DET
aiua-8854	23	54	available	available	ADJ
aiua-8854	23	55	systemic	systemic	ADJ
aiua-8854	23	56	mcrpc	mcrpc	PROPN
aiua-8854	23	57	treatment	treatment	NOUN
aiua-8854	23	58	(	(	PUNCT
aiua-8854	23	59	17	17	NUM
aiua-8854	23	60	)	)	PUNCT
aiua-8854	23	61	.	.	PUNCT
aiua-8854	24	1	pharmacovigilance	pharmacovigilance	NOUN
aiua-8854	24	2	risk	risk	NOUN
aiua-8854	24	3	assessment	assessment	NOUN
aiua-8854	24	4	committee	committee	NOUN
aiua-8854	24	5	(	(	PUNCT
aiua-8854	24	6	prac	prac	NOUN
aiua-8854	24	7	)	)	PUNCT
aiua-8854	24	8	of	of	ADP
aiua-8854	24	9	european	european	PROPN
aiua-8854	24	10	medicines	medicine	NOUN
aiua-8854	24	11	agency	agency	NOUN
aiua-8854	24	12	(	(	PUNCT
aiua-8854	24	13	ema	ema	PROPN
aiua-8854	24	14	)	)	PUNCT
aiua-8854	24	15	carried	carry	VERB
aiua-8854	24	16	out	out	ADP
aiua-8854	24	17	a	a	DET
aiua-8854	24	18	review	review	NOUN
aiua-8854	24	19	on	on	ADP
aiua-8854	24	20	radium-223	radium-223	NOUN
aiua-8854	24	21	after	after	SCONJ
aiua-8854	24	22	data	datum	NOUN
aiua-8854	24	23	from	from	ADP
aiua-8854	24	24	a	a	DET
aiua-8854	24	25	clinical	clinical	ADJ
aiua-8854	24	26	study	study	NOUN
aiua-8854	24	27	suggested	suggest	VERB
aiua-8854	24	28	that	that	SCONJ
aiua-8854	24	29	patients	patient	NOUN
aiua-8854	24	30	treated	treat	VERB
aiua-8854	24	31	with	with	ADP
aiua-8854	24	32	radium-223	radium-223	NOUN
aiua-8854	24	33	in	in	ADP
aiua-8854	24	34	combination	combination	NOUN
aiua-8854	24	35	with	with	ADP
aiua-8854	24	36	abiraterone	abiraterone	NOUN
aiua-8854	24	37	and	and	CCONJ
aiua-8854	24	38	prednisone	prednisone	PROPN
aiua-8854	24	39	/	/	SYM
aiua-8854	24	40	prednisolone	prednisolone	PROPN
aiua-8854	24	41	could	could	AUX
aiua-8854	24	42	be	be	AUX
aiua-8854	24	43	at	at	ADP
aiua-8854	24	44	risk	risk	NOUN
aiua-8854	24	45	of	of	ADP
aiua-8854	24	46	dying	die	VERB
aiua-8854	24	47	earlier	early	ADV
aiua-8854	24	48	and	and	CCONJ
aiua-8854	24	49	had	have	VERB
aiua-8854	24	50	more	more	ADJ
aiua-8854	24	51	fractures	fracture	NOUN
aiua-8854	24	52	than	than	ADP
aiua-8854	24	53	patients	patient	NOUN
aiua-8854	24	54	given	give	VERB
aiua-8854	24	55	placebo	placebo	NOUN
aiua-8854	24	56	with	with	ADP
aiua-8854	24	57	abiraterone	abiraterone	NOUN
aiua-8854	24	58	and	and	CCONJ
aiua-8854	24	59	prednisone	prednisone	NOUN
aiua-8854	24	60	/	/	SYM
aiua-8854	24	61	prednisolone	prednisolone	PROPN
aiua-8854	24	62	(	(	PUNCT
aiua-8854	24	63	18	18	NUM
aiua-8854	24	64	)	)	PUNCT
aiua-8854	24	65	.	.	PUNCT
aiua-8854	25	1	the	the	DET
aiua-8854	25	2	above	above	ADJ
aiua-8854	25	3	recommendations	recommendation	NOUN
aiua-8854	25	4	are	be	AUX
aiua-8854	25	5	based	base	VERB
aiua-8854	25	6	on	on	ADP
aiua-8854	25	7	the	the	DET
aiua-8854	25	8	assessment	assessment	NOUN
aiua-8854	25	9	of	of	ADP
aiua-8854	25	10	data	datum	NOUN
aiua-8854	25	11	resulting	result	VERB
aiua-8854	25	12	from	from	ADP
aiua-8854	25	13	a	a	DET
aiua-8854	25	14	randomized	randomized	ADJ
aiua-8854	25	15	,	,	PUNCT
aiua-8854	25	16	double	double	ADJ
aiua-8854	25	17	-	-	PUNCT
aiua-8854	25	18	blind	blind	ADJ
aiua-8854	25	19	,	,	PUNCT
aiua-8854	25	20	placebo	placebo	NOUN
aiua-8854	25	21	-	-	PUNCT
aiua-8854	25	22	controlled	control	VERB
aiua-8854	25	23	phase	phase	NOUN
aiua-8854	25	24	iii	iii	NOUN
aiua-8854	25	25	trial	trial	NOUN
aiua-8854	25	26	(	(	PUNCT
aiua-8854	25	27	era-223	era-223	PROPN
aiua-8854	25	28	)	)	PUNCT
aiua-8854	25	29	,	,	PUNCT
aiua-8854	25	30	which	which	PRON
aiua-8854	25	31	showed	show	VERB
aiua-8854	25	32	an	an	DET
aiua-8854	25	33	increased	increase	VERB
aiua-8854	25	34	incidence	incidence	NOUN
aiua-8854	25	35	of	of	ADP
aiua-8854	25	36	skeletal	skeletal	ADJ
aiua-8854	25	37	-	-	PUNCT
aiua-8854	25	38	related	relate	VERB
aiua-8854	25	39	events	event	NOUN
aiua-8854	25	40	(	(	PUNCT
aiua-8854	25	41	sre	sre	NOUN
aiua-8854	25	42	)	)	PUNCT
aiua-8854	25	43	(	(	PUNCT
aiua-8854	25	44	28.6	28.6	NUM
aiua-8854	25	45	%	%	NOUN
aiua-8854	25	46	vs	vs	ADP
aiua-8854	25	47	11.4	11.4	NUM
aiua-8854	25	48	%	%	NOUN
aiua-8854	25	49	)	)	PUNCT
aiua-8854	25	50	,	,	PUNCT
aiua-8854	25	51	a	a	DET
aiua-8854	25	52	possible	possible	ADJ
aiua-8854	25	53	reduction	reduction	NOUN
aiua-8854	25	54	in	in	ADP
aiua-8854	25	55	median	median	ADJ
aiua-8854	25	56	overall	overall	ADJ
aiua-8854	25	57	survival	survival	NOUN
aiua-8854	25	58	(	(	PUNCT
aiua-8854	25	59	os	os	NOUN
aiua-8854	25	60	)	)	PUNCT
aiua-8854	25	61	(	(	PUNCT
aiua-8854	25	62	30.7	30.7	NUM
aiua-8854	25	63	months	month	NOUN
aiua-8854	25	64	vs	vs	ADP
aiua-8854	25	65	33.3	33.3	NUM
aiua-8854	25	66	months	month	NOUN
aiua-8854	25	67	,	,	PUNCT
aiua-8854	25	68	hr	hr	NOUN
aiua-8854	25	69	1.195	1.195	NUM
aiua-8854	25	70	,	,	PUNCT
aiua-8854	25	71	p	p	NOUN
aiua-8854	25	72	=	=	NOUN
aiua-8854	25	73	0.13	0.13	NUM
aiua-8854	25	74	)	)	PUNCT
aiua-8854	25	75	and	and	CCONJ
aiua-8854	25	76	an	an	DET
aiua-8854	25	77	increased	increase	VERB
aiua-8854	25	78	risk	risk	NOUN
aiua-8854	25	79	of	of	ADP
aiua-8854	25	80	radiological	radiological	ADJ
aiua-8854	25	81	non	non	ADJ
aiua-8854	25	82	-	-	ADJ
aiua-8854	25	83	bone	bone	ADJ
aiua-8854	25	84	progression	progression	NOUN
aiua-8854	25	85	(	(	PUNCT
aiua-8854	25	86	hr	hr	NOUN
aiua-8854	25	87	1.376	1.376	NUM
aiua-8854	25	88	,	,	PUNCT
aiua-8854	25	89	p	p	X
aiua-8854	25	90	=	=	NOUN
aiua-8854	25	91	0.07	0.07	NUM
aiua-8854	25	92	)	)	PUNCT
aiua-8854	25	93	among	among	ADP
aiua-8854	25	94	patients	patient	NOUN
aiua-8854	25	95	receiving	receive	VERB
aiua-8854	25	96	radium-223	radium-223	NOUN
aiua-8854	25	97	in	in	ADP
aiua-8854	25	98	combination	combination	NOUN
aiua-8854	25	99	with	with	ADP
aiua-8854	25	100	abiraterone	abiraterone	NOUN
aiua-8854	25	101	acetate	acetate	NOUN
aiua-8854	25	102	plus	plus	CCONJ
aiua-8854	25	103	prednisone	prednisone	PROPN
aiua-8854	25	104	/	/	SYM
aiua-8854	25	105	prednisolone	prednisolone	PROPN
aiua-8854	25	106	(	(	PUNCT
aiua-8854	25	107	n	n	NOUN
aiua-8854	25	108	=	=	SYM
aiua-8854	25	109	401	401	NUM
aiua-8854	25	110	)	)	PUNCT
aiua-8854	25	111	compared	compare	VERB
aiua-8854	25	112	to	to	ADP
aiua-8854	25	113	patients	patient	NOUN
aiua-8854	25	114	receiving	receive	VERB
aiua-8854	25	115	placebo	placebo	NOUN
aiua-8854	25	116	in	in	ADP
aiua-8854	25	117	combination	combination	NOUN
aiua-8854	25	118	with	with	ADP
aiua-8854	25	119	abiraterone	abiraterone	NOUN
aiua-8854	25	120	acetate	acetate	NOUN
aiua-8854	25	121	plus	plus	CCONJ
aiua-8854	25	122	prednisone	prednisone	PROPN
aiua-8854	25	123	/	/	SYM
aiua-8854	25	124	prednisolone	prednisolone	PROPN
aiua-8854	25	125	(	(	PUNCT
aiua-8854	25	126	n	n	NOUN
aiua-8854	25	127	=	=	SYM
aiua-8854	25	128	405	405	NUM
aiua-8854	25	129	)	)	PUNCT
aiua-8854	25	130	(	(	PUNCT
aiua-8854	25	131	19	19	NUM
aiua-8854	25	132	)	)	PUNCT
aiua-8854	25	133	.	.	PUNCT
aiua-8854	26	1	despite	despite	SCONJ
aiua-8854	26	2	several	several	ADJ
aiua-8854	26	3	clinical	clinical	ADJ
aiua-8854	26	4	trials	trial	NOUN
aiua-8854	26	5	and	and	CCONJ
aiua-8854	26	6	prospective	prospective	ADJ
aiua-8854	26	7	studies	study	NOUN
aiua-8854	26	8	have	have	AUX
aiua-8854	26	9	been	be	AUX
aiua-8854	26	10	carried	carry	VERB
aiua-8854	26	11	out	out	ADP
aiua-8854	26	12	aiming	aim	VERB
aiua-8854	26	13	to	to	PART
aiua-8854	26	14	investigate	investigate	VERB
aiua-8854	26	15	the	the	DET
aiua-8854	26	16	outcomes	outcome	NOUN
aiua-8854	26	17	of	of	ADP
aiua-8854	26	18	radium-223	radium-223	NOUN
aiua-8854	26	19	therapy	therapy	NOUN
aiua-8854	26	20	in	in	ADP
aiua-8854	26	21	terms	term	NOUN
aiua-8854	26	22	of	of	ADP
aiua-8854	26	23	os	os	NOUN
aiua-8854	26	24	,	,	PUNCT
aiua-8854	26	25	progression	progression	NOUN
aiua-8854	26	26	-	-	PUNCT
aiua-8854	26	27	free	free	ADJ
aiua-8854	26	28	survival	survival	NOUN
aiua-8854	26	29	(	(	PUNCT
aiua-8854	26	30	pfs	pfs	PROPN
aiua-8854	26	31	)	)	PUNCT
aiua-8854	26	32	,	,	PUNCT
aiua-8854	26	33	sre	sre	NOUN
aiua-8854	26	34	and	and	CCONJ
aiua-8854	26	35	multiple	multiple	ADJ
aiua-8854	26	36	qol	qol	NOUN
aiua-8854	26	37	parameters	parameter	NOUN
aiua-8854	26	38	(	(	PUNCT
aiua-8854	26	39	20	20	NUM
aiua-8854	26	40	)	)	PUNCT
aiua-8854	26	41	,	,	PUNCT
aiua-8854	26	42	to	to	ADP
aiua-8854	26	43	our	our	PRON
aiua-8854	26	44	knowledge	knowledge	NOUN
aiua-8854	26	45	,	,	PUNCT
aiua-8854	26	46	in	in	ADP
aiua-8854	26	47	the	the	DET
aiua-8854	26	48	literature	literature	NOUN
aiua-8854	26	49	there	there	PRON
aiua-8854	26	50	are	be	VERB
aiua-8854	26	51	no	no	DET
aiua-8854	26	52	studies	study	NOUN
aiua-8854	26	53	assessing	assess	VERB
aiua-8854	26	54	specifically	specifically	ADV
aiua-8854	26	55	the	the	DET
aiua-8854	26	56	bone	bone	NOUN
aiua-8854	26	57	pain	pain	NOUN
aiua-8854	26	58	palliation	palliation	NOUN
aiua-8854	26	59	outcomes	outcome	NOUN
aiua-8854	26	60	,	,	PUNCT
aiua-8854	26	61	as	as	ADP
aiua-8854	26	62	an	an	DET
aiua-8854	26	63	independent	independent	ADJ
aiua-8854	26	64	factor	factor	NOUN
aiua-8854	26	65	,	,	PUNCT
aiua-8854	26	66	following	follow	VERB
aiua-8854	26	67	the	the	DET
aiua-8854	26	68	end	end	NOUN
aiua-8854	26	69	of	of	ADP
aiua-8854	26	70	radium-223	radium-223	NOUN
aiua-8854	26	71	treatment	treatment	NOUN
aiua-8854	26	72	.	.	PUNCT
aiua-8854	27	1	the	the	DET
aiua-8854	27	2	following	follow	VERB
aiua-8854	27	3	study	study	NOUN
aiua-8854	27	4	08fantellizzi_stesura	08fantellizzi_stesura	PROPN
aiua-8854	27	5	seveso	seveso	PROPN
aiua-8854	27	6	24/09/20	24/09/20	PROPN
aiua-8854	27	7	14:19	14:19	NUM
aiua-8854	27	8	pagina	pagina	NOUN
aiua-8854	27	9	196	196	NUM
aiua-8854	27	10	197archivio	197archivio	PROPN
aiua-8854	27	11	italiano	italiano	NOUN
aiua-8854	27	12	di	di	NOUN
aiua-8854	27	13	urologia	urologia	PROPN
aiua-8854	27	14	e	e	PROPN
aiua-8854	27	15	andrologia	andrologia	NOUN
aiua-8854	27	16	2020	2020	NUM
aiua-8854	27	17	;	;	PUNCT
aiua-8854	27	18	92	92	NUM
aiua-8854	27	19	,	,	PUNCT
aiua-8854	27	20	3	3	NUM
aiua-8854	27	21	bone	bone	NOUN
aiua-8854	27	22	pain	pain	NOUN
aiua-8854	27	23	palliation	palliation	NOUN
aiua-8854	27	24	and	and	CCONJ
aiua-8854	27	25	radium-223	radium-223	NOUN
aiua-8854	27	26	re	re	NOUN
aiua-8854	27	27	-	-	NOUN
aiua-8854	27	28	treatment	treatment	NOUN
aiua-8854	27	29	describes	describe	VERB
aiua-8854	27	30	a	a	DET
aiua-8854	27	31	mcrpc	mcrpc	NOUN
aiua-8854	27	32	patient	patient	NOUN
aiua-8854	27	33	,	,	PUNCT
aiua-8854	27	34	presenting	present	VERB
aiua-8854	27	35	a	a	DET
aiua-8854	27	36	significant	significant	ADJ
aiua-8854	27	37	reduction	reduction	NOUN
aiua-8854	27	38	of	of	ADP
aiua-8854	27	39	bone	bone	NOUN
aiua-8854	27	40	pain	pain	NOUN
aiua-8854	27	41	during	during	ADP
aiua-8854	27	42	the	the	DET
aiua-8854	27	43	therapy	therapy	NOUN
aiua-8854	27	44	,	,	PUNCT
aiua-8854	27	45	followed	follow	VERB
aiua-8854	27	46	by	by	ADP
aiua-8854	27	47	further	further	ADJ
aiua-8854	27	48	bone	bone	NOUN
aiua-8854	27	49	pain	pain	NOUN
aiua-8854	27	50	palliation	palliation	NOUN
aiua-8854	27	51	after	after	ADP
aiua-8854	27	52	the	the	DET
aiua-8854	27	53	first	first	ADJ
aiua-8854	27	54	3	3	NUM
aiua-8854	27	55	months	month	NOUN
aiua-8854	27	56	following	follow	VERB
aiua-8854	27	57	the	the	DET
aiua-8854	27	58	end	end	NOUN
aiua-8854	27	59	of	of	ADP
aiua-8854	27	60	radium-223	radium-223	NOUN
aiua-8854	27	61	therapy	therapy	NOUN
aiua-8854	27	62	without	without	ADP
aiua-8854	27	63	modification	modification	NOUN
aiua-8854	27	64	of	of	ADP
aiua-8854	27	65	pain	pain	NOUN
aiua-8854	27	66	-	-	PUNCT
aiua-8854	27	67	relieving	relieve	VERB
aiua-8854	27	68	medications	medication	NOUN
aiua-8854	27	69	.	.	PUNCT
aiua-8854	28	1	materials	material	NOUN
aiua-8854	28	2	and	and	CCONJ
aiua-8854	28	3	methods	method	NOUN
aiua-8854	28	4	a	a	DET
aiua-8854	28	5	77	77	NUM
aiua-8854	28	6	years	year	NOUN
aiua-8854	28	7	-	-	PUNCT
aiua-8854	28	8	old	old	ADJ
aiua-8854	28	9	man	man	NOUN
aiua-8854	28	10	was	be	AUX
aiua-8854	28	11	diagnosed	diagnose	VERB
aiua-8854	28	12	with	with	ADP
aiua-8854	28	13	pca	pca	PROPN
aiua-8854	28	14	(	(	PUNCT
aiua-8854	28	15	gleason	gleason	PROPN
aiua-8854	28	16	score	score	NOUN
aiua-8854	28	17	9	9	NUM
aiua-8854	28	18	,	,	PUNCT
aiua-8854	28	19	4	4	NUM
aiua-8854	28	20	+	+	NOUN
aiua-8854	28	21	5	5	NUM
aiua-8854	28	22	)	)	PUNCT
aiua-8854	28	23	in	in	ADP
aiua-8854	28	24	february	february	PROPN
aiua-8854	28	25	2014	2014	NUM
aiua-8854	28	26	.	.	PUNCT
aiua-8854	29	1	he	he	PRON
aiua-8854	29	2	began	begin	VERB
aiua-8854	29	3	adt	adt	NOUN
aiua-8854	29	4	with	with	ADP
aiua-8854	29	5	triptorelin	triptorelin	NOUN
aiua-8854	29	6	and	and	CCONJ
aiua-8854	29	7	bicalutamide	bicalutamide	VERB
aiua-8854	29	8	for	for	ADP
aiua-8854	29	9	19	19	NUM
aiua-8854	29	10	months	month	NOUN
aiua-8854	29	11	.	.	PUNCT
aiua-8854	30	1	furthermore	furthermore	ADV
aiua-8854	30	2	,	,	PUNCT
aiua-8854	30	3	after	after	ADP
aiua-8854	30	4	2	2	NUM
aiua-8854	30	5	years	year	NOUN
aiua-8854	30	6	from	from	ADP
aiua-8854	30	7	the	the	DET
aiua-8854	30	8	diagnosis	diagnosis	NOUN
aiua-8854	30	9	,	,	PUNCT
aiua-8854	30	10	he	he	PRON
aiua-8854	30	11	has	have	AUX
aiua-8854	30	12	been	be	AUX
aiua-8854	30	13	treated	treat	VERB
aiua-8854	30	14	with	with	ADP
aiua-8854	30	15	external	external	ADJ
aiua-8854	30	16	beam	beam	NOUN
aiua-8854	30	17	radiation	radiation	NOUN
aiua-8854	30	18	therapy	therapy	NOUN
aiua-8854	30	19	(	(	PUNCT
aiua-8854	30	20	ebrt	ebrt	ADJ
aiua-8854	30	21	)	)	PUNCT
aiua-8854	30	22	to	to	ADP
aiua-8854	30	23	secondary	secondary	ADJ
aiua-8854	30	24	bone	bone	NOUN
aiua-8854	30	25	lesions	lesion	NOUN
aiua-8854	30	26	on	on	ADP
aiua-8854	30	27	the	the	DET
aiua-8854	30	28	right	right	ADJ
aiua-8854	30	29	pelvis	pelvis	NOUN
aiua-8854	30	30	.	.	PUNCT
aiua-8854	31	1	he	he	PRON
aiua-8854	31	2	came	come	VERB
aiua-8854	31	3	to	to	ADP
aiua-8854	31	4	our	our	PRON
aiua-8854	31	5	attention	attention	NOUN
aiua-8854	31	6	in	in	ADP
aiua-8854	31	7	november	november	PROPN
aiua-8854	31	8	2016	2016	NUM
aiua-8854	31	9	with	with	ADP
aiua-8854	31	10	a	a	DET
aiua-8854	31	11	psa	psa	NOUN
aiua-8854	31	12	recurrence	recurrence	NOUN
aiua-8854	31	13	(	(	PUNCT
aiua-8854	31	14	psa	psa	VERB
aiua-8854	31	15	168	168	NUM
aiua-8854	31	16	ng	ng	NOUN
aiua-8854	31	17	/	/	SYM
aiua-8854	31	18	ml	ml	VERB
aiua-8854	31	19	)	)	PUNCT
aiua-8854	31	20	despite	despite	SCONJ
aiua-8854	31	21	adt	adt	NOUN
aiua-8854	31	22	,	,	PUNCT
aiua-8854	31	23	his	his	PRON
aiua-8854	31	24	testosterone	testosterone	NOUN
aiua-8854	31	25	level	level	NOUN
aiua-8854	31	26	was	be	AUX
aiua-8854	31	27	0.34	0.34	NUM
aiua-8854	31	28	ng	ng	PROPN
aiua-8854	31	29	/	/	SYM
aiua-8854	31	30	dl	dl	PROPN
aiua-8854	31	31	)	)	PUNCT
aiua-8854	31	32	,	,	PUNCT
aiua-8854	31	33	therefore	therefore	ADV
aiua-8854	31	34	he	he	PRON
aiua-8854	31	35	was	be	AUX
aiua-8854	31	36	diagnosed	diagnose	VERB
aiua-8854	31	37	with	with	ADP
aiua-8854	31	38	mcrpc	mcrpc	NOUN
aiua-8854	31	39	.	.	PUNCT
aiua-8854	32	1	the	the	DET
aiua-8854	32	2	patient	patient	NOUN
aiua-8854	32	3	presented	present	VERB
aiua-8854	32	4	positive	positive	ADJ
aiua-8854	32	5	99mtc	99mtc	ADJ
aiua-8854	32	6	-	-	PUNCT
aiua-8854	32	7	hdp	hdp	NOUN
aiua-8854	32	8	bone	bone	NOUN
aiua-8854	32	9	scan	scan	PROPN
aiua-8854	32	10	imaging	imaging	NOUN
aiua-8854	32	11	with	with	ADP
aiua-8854	32	12	increased	increase	VERB
aiua-8854	32	13	uptake	uptake	NOUN
aiua-8854	32	14	in	in	ADP
aiua-8854	32	15	the	the	DET
aiua-8854	32	16	cranium	cranium	NOUN
aiua-8854	32	17	,	,	PUNCT
aiua-8854	32	18	in	in	ADP
aiua-8854	32	19	both	both	DET
aiua-8854	32	20	scapulae	scapulae	NOUN
aiua-8854	32	21	,	,	PUNCT
aiua-8854	32	22	in	in	ADP
aiua-8854	32	23	the	the	DET
aiua-8854	32	24	left	left	ADJ
aiua-8854	32	25	humerus	humerus	NOUN
aiua-8854	32	26	and	and	CCONJ
aiua-8854	32	27	radius	radius	NOUN
aiua-8854	32	28	,	,	PUNCT
aiua-8854	32	29	in	in	ADP
aiua-8854	32	30	multiple	multiple	ADJ
aiua-8854	32	31	ribs	rib	NOUN
aiua-8854	32	32	and	and	CCONJ
aiua-8854	32	33	vertebrae	vertebrae	NOUN
aiua-8854	32	34	,	,	PUNCT
aiua-8854	32	35	in	in	ADP
aiua-8854	32	36	the	the	DET
aiua-8854	32	37	pelvis	pelvi	NOUN
aiua-8854	32	38	and	and	CCONJ
aiua-8854	32	39	in	in	ADP
aiua-8854	32	40	the	the	DET
aiua-8854	32	41	left	left	ADJ
aiua-8854	32	42	femur	femur	NOUN
aiua-8854	32	43	(	(	PUNCT
aiua-8854	32	44	figure	figure	NOUN
aiua-8854	32	45	1a	1a	NOUN
aiua-8854	32	46	)	)	PUNCT
aiua-8854	32	47	.	.	PUNCT
aiua-8854	33	1	the	the	DET
aiua-8854	33	2	ct	ct	PROPN
aiua-8854	33	3	scan	scan	NOUN
aiua-8854	33	4	was	be	AUX
aiua-8854	33	5	negative	negative	ADJ
aiua-8854	33	6	for	for	ADP
aiua-8854	33	7	visceral	visceral	ADJ
aiua-8854	33	8	metastasis	metastasis	NOUN
aiua-8854	33	9	.	.	PUNCT
aiua-8854	34	1	he	he	PRON
aiua-8854	34	2	was	be	AUX
aiua-8854	34	3	defined	define	VERB
aiua-8854	34	4	as	as	ADP
aiua-8854	34	5	a	a	DET
aiua-8854	34	6	poly	poly	ADJ
aiua-8854	34	7	-	-	PUNCT
aiua-8854	34	8	metastatic	metastatic	ADJ
aiua-8854	34	9	patient	patient	NOUN
aiua-8854	34	10	(	(	PUNCT
aiua-8854	34	11	6	6	NUM
aiua-8854	34	12	-	-	SYM
aiua-8854	34	13	20	20	NUM
aiua-8854	34	14	metastatic	metastatic	ADJ
aiua-8854	34	15	foci	focus	NOUN
aiua-8854	34	16	)	)	PUNCT
aiua-8854	34	17	.	.	PUNCT
aiua-8854	35	1	therefore	therefore	ADV
aiua-8854	35	2	,	,	PUNCT
aiua-8854	35	3	we	we	PRON
aiua-8854	35	4	started	start	VERB
aiua-8854	35	5	radium-223	radium-223	NOUN
aiua-8854	35	6	treatment	treatment	NOUN
aiua-8854	35	7	.	.	PUNCT
aiua-8854	36	1	the	the	DET
aiua-8854	36	2	brief	brief	ADJ
aiua-8854	36	3	pain	pain	NOUN
aiua-8854	36	4	inventory	inventory	NOUN
aiua-8854	36	5	by	by	ADP
aiua-8854	36	6	numeric	numeric	ADJ
aiua-8854	36	7	rating	rating	NOUN
aiua-8854	36	8	scale	scale	NOUN
aiua-8854	36	9	(	(	PUNCT
aiua-8854	36	10	bpi	bpi	NOUN
aiua-8854	36	11	)	)	PUNCT
aiua-8854	36	12	value	value	NOUN
aiua-8854	36	13	was	be	AUX
aiua-8854	36	14	7	7	NUM
aiua-8854	36	15	in	in	ADP
aiua-8854	36	16	spite	spite	NOUN
aiua-8854	36	17	of	of	ADP
aiua-8854	36	18	nonsteroidal	nonsteroidal	NOUN
aiua-8854	36	19	antiinflammatory	antiinflammatory	NOUN
aiua-8854	36	20	drug	drug	NOUN
aiua-8854	36	21	(	(	PUNCT
aiua-8854	36	22	nsaid	nsaid	PROPN
aiua-8854	36	23	)	)	PUNCT
aiua-8854	36	24	(	(	PUNCT
aiua-8854	36	25	ketorolac	ketorolac	X
aiua-8854	36	26	)	)	PUNCT
aiua-8854	36	27	and	and	CCONJ
aiua-8854	36	28	acetaminophen	acetaminophen	NOUN
aiua-8854	36	29	treatment	treatment	NOUN
aiua-8854	36	30	.	.	PUNCT
aiua-8854	37	1	results	result	NOUN
aiua-8854	37	2	after	after	ADP
aiua-8854	37	3	6	6	NUM
aiua-8854	37	4	cycles	cycle	NOUN
aiua-8854	37	5	of	of	ADP
aiua-8854	37	6	radium-223	radium-223	NOUN
aiua-8854	37	7	treatment	treatment	NOUN
aiua-8854	37	8	,	,	PUNCT
aiua-8854	37	9	bpi	bpi	PROPN
aiua-8854	37	10	declined	decline	VERB
aiua-8854	37	11	from	from	ADP
aiua-8854	37	12	7	7	NUM
aiua-8854	37	13	to	to	ADP
aiua-8854	37	14	4	4	NUM
aiua-8854	37	15	without	without	ADP
aiua-8854	37	16	modification	modification	NOUN
aiua-8854	37	17	of	of	ADP
aiua-8854	37	18	pain	pain	NOUN
aiua-8854	37	19	-	-	PUNCT
aiua-8854	37	20	relieving	relieve	VERB
aiua-8854	37	21	medications	medication	NOUN
aiua-8854	37	22	.	.	PUNCT
aiua-8854	38	1	the	the	DET
aiua-8854	38	2	bone	bone	NOUN
aiua-8854	38	3	scan	scan	PROPN
aiua-8854	38	4	performed	perform	VERB
aiua-8854	38	5	in	in	ADP
aiua-8854	38	6	april	april	PROPN
aiua-8854	38	7	2017	2017	NUM
aiua-8854	38	8	showed	show	VERB
aiua-8854	38	9	a	a	DET
aiua-8854	38	10	partial	partial	ADJ
aiua-8854	38	11	regression	regression	NOUN
aiua-8854	38	12	of	of	ADP
aiua-8854	38	13	multiple	multiple	ADJ
aiua-8854	38	14	bone	bone	NOUN
aiua-8854	38	15	hot	hot	ADJ
aiua-8854	38	16	spots	spot	NOUN
aiua-8854	38	17	(	(	PUNCT
aiua-8854	38	18	figure	figure	NOUN
aiua-8854	38	19	1b	1b	NUM
aiua-8854	38	20	)	)	PUNCT
aiua-8854	38	21	.	.	PUNCT
aiua-8854	39	1	the	the	DET
aiua-8854	39	2	patient	patient	NOUN
aiua-8854	39	3	reported	report	VERB
aiua-8854	39	4	further	further	ADJ
aiua-8854	39	5	improvement	improvement	NOUN
aiua-8854	39	6	with	with	ADP
aiua-8854	39	7	bpi	bpi	PROPN
aiua-8854	39	8	that	that	PRON
aiua-8854	39	9	declined	decline	VERB
aiua-8854	39	10	from	from	ADP
aiua-8854	39	11	4	4	NUM
aiua-8854	39	12	to	to	PART
aiua-8854	39	13	2	2	NUM
aiua-8854	39	14	after	after	ADP
aiua-8854	39	15	3	3	NUM
aiua-8854	39	16	months	month	NOUN
aiua-8854	39	17	from	from	ADP
aiua-8854	39	18	the	the	DET
aiua-8854	39	19	last	last	ADJ
aiua-8854	39	20	administration	administration	NOUN
aiua-8854	39	21	of	of	ADP
aiua-8854	39	22	radium-223	radium-223	NOUN
aiua-8854	39	23	treatment	treatment	NOUN
aiua-8854	39	24	with	with	ADP
aiua-8854	39	25	stable	stable	ADJ
aiua-8854	39	26	disease	disease	NOUN
aiua-8854	39	27	resulting	result	VERB
aiua-8854	39	28	in	in	ADP
aiua-8854	39	29	the	the	DET
aiua-8854	39	30	bone	bone	NOUN
aiua-8854	39	31	scan	scan	NOUN
aiua-8854	39	32	.	.	PUNCT
aiua-8854	40	1	nevertheless	nevertheless	ADV
aiua-8854	40	2	,	,	PUNCT
aiua-8854	40	3	at	at	ADP
aiua-8854	40	4	6	6	NUM
aiua-8854	40	5	months	month	NOUN
aiua-8854	40	6	follow	follow	VERB
aiua-8854	40	7	-	-	PUNCT
aiua-8854	40	8	up	up	ADP
aiua-8854	40	9	bpi	bpi	PROPN
aiua-8854	40	10	increased	increase	VERB
aiua-8854	40	11	from	from	ADP
aiua-8854	40	12	2	2	NUM
aiua-8854	40	13	to	to	ADP
aiua-8854	40	14	10	10	NUM
aiua-8854	40	15	without	without	ADP
aiua-8854	40	16	modification	modification	NOUN
aiua-8854	40	17	of	of	ADP
aiua-8854	40	18	pain	pain	NOUN
aiua-8854	40	19	-	-	PUNCT
aiua-8854	40	20	relieving	relieve	VERB
aiua-8854	40	21	medications	medication	NOUN
aiua-8854	40	22	.	.	PUNCT
aiua-8854	41	1	pain	pain	NOUN
aiua-8854	41	2	score	score	NOUN
aiua-8854	41	3	measurements	measurement	NOUN
aiua-8854	41	4	during	during	ADP
aiua-8854	41	5	and	and	CCONJ
aiua-8854	41	6	after	after	SCONJ
aiua-8854	41	7	the	the	DET
aiua-8854	41	8	radium-223	radium-223	NOUN
aiua-8854	41	9	treatment	treatment	NOUN
aiua-8854	41	10	are	be	AUX
aiua-8854	41	11	shown	show	VERB
aiua-8854	41	12	in	in	ADP
aiua-8854	41	13	figure	figure	NOUN
aiua-8854	41	14	2	2	NUM
aiua-8854	41	15	.	.	PUNCT
aiua-8854	42	1	the	the	DET
aiua-8854	42	2	patient	patient	NOUN
aiua-8854	42	3	showed	show	VERB
aiua-8854	42	4	progression	progression	NOUN
aiua-8854	42	5	in	in	ADP
aiua-8854	42	6	the	the	DET
aiua-8854	42	7	99mtc	99mtc	PROPN
aiua-8854	42	8	-	-	PUNCT
aiua-8854	42	9	hdp	hdp	NOUN
aiua-8854	42	10	bone	bone	NOUN
aiua-8854	42	11	scan	scan	PROPN
aiua-8854	42	12	performed	perform	VERB
aiua-8854	42	13	in	in	ADP
aiua-8854	42	14	october	october	PROPN
aiua-8854	42	15	2017	2017	NUM
aiua-8854	42	16	,	,	PUNCT
aiua-8854	42	17	after	after	ADP
aiua-8854	42	18	6	6	NUM
aiua-8854	42	19	months	month	NOUN
aiua-8854	42	20	from	from	ADP
aiua-8854	42	21	the	the	DET
aiua-8854	42	22	end	end	NOUN
aiua-8854	42	23	of	of	ADP
aiua-8854	42	24	the	the	DET
aiua-8854	42	25	radium-223	radium-223	NOUN
aiua-8854	42	26	therapy	therapy	NOUN
aiua-8854	42	27	(	(	PUNCT
aiua-8854	42	28	figure	figure	NOUN
aiua-8854	42	29	1c	1c	NOUN
aiua-8854	42	30	)	)	PUNCT
aiua-8854	42	31	,	,	PUNCT
aiua-8854	42	32	with	with	SCONJ
aiua-8854	42	33	extension	extension	NOUN
aiua-8854	42	34	of	of	ADP
aiua-8854	42	35	the	the	DET
aiua-8854	42	36	areas	area	NOUN
aiua-8854	42	37	of	of	ADP
aiua-8854	42	38	pathological	pathological	ADJ
aiua-8854	42	39	uptake	uptake	NOUN
aiua-8854	42	40	previously	previously	ADV
aiua-8854	42	41	reported	report	VERB
aiua-8854	42	42	.	.	PUNCT
aiua-8854	43	1	unfortunately	unfortunately	ADV
aiua-8854	43	2	,	,	PUNCT
aiua-8854	43	3	after	after	ADP
aiua-8854	43	4	13	13	NUM
aiua-8854	43	5	months	month	NOUN
aiua-8854	43	6	of	of	ADP
aiua-8854	43	7	follow	follow	NOUN
aiua-8854	43	8	-	-	PUNCT
aiua-8854	43	9	up	up	NOUN
aiua-8854	43	10	,	,	PUNCT
aiua-8854	43	11	the	the	DET
aiua-8854	43	12	patient	patient	NOUN
aiua-8854	43	13	died	die	VERB
aiua-8854	43	14	for	for	ADP
aiua-8854	43	15	multi	multi	ADJ
aiua-8854	43	16	-	-	ADJ
aiua-8854	43	17	organ	organ	ADJ
aiua-8854	43	18	failure	failure	NOUN
aiua-8854	43	19	.	.	PUNCT
aiua-8854	44	1	figure	figure	NOUN
aiua-8854	44	2	1a	1a	PROPN
aiua-8854	44	3	.	.	PUNCT
aiua-8854	45	1	baseline	baseline	PROPN
aiua-8854	45	2	99mtc	99mtc	PROPN
aiua-8854	45	3	-	-	PUNCT
aiua-8854	45	4	hdp	hdp	NOUN
aiua-8854	45	5	bone	bone	NOUN
aiua-8854	45	6	scan	scan	PROPN
aiua-8854	45	7	imaging	imaging	PROPN
aiua-8854	45	8	.	.	PUNCT
aiua-8854	46	1	figure	figure	NOUN
aiua-8854	46	2	1b	1b	NUM
aiua-8854	46	3	.	.	PUNCT
aiua-8854	47	1	end	end	NOUN
aiua-8854	47	2	-	-	PUNCT
aiua-8854	47	3	of	of	ADP
aiua-8854	47	4	treatment	treatment	NOUN
aiua-8854	47	5	99mtc	99mtc	NOUN
aiua-8854	47	6	-	-	PUNCT
aiua-8854	47	7	hdp	hdp	NOUN
aiua-8854	47	8	bone	bone	NOUN
aiua-8854	47	9	scan	scan	PROPN
aiua-8854	47	10	imaging	imaging	PROPN
aiua-8854	47	11	.	.	PUNCT
aiua-8854	48	1	figure	figure	NOUN
aiua-8854	48	2	1c	1c	NOUN
aiua-8854	48	3	.	.	PUNCT
aiua-8854	49	1	99mtc	99mtc	ADJ
aiua-8854	49	2	-	-	PUNCT
aiua-8854	49	3	hdp	hdp	NOUN
aiua-8854	49	4	bone	bone	NOUN
aiua-8854	49	5	scan	scan	PROPN
aiua-8854	49	6	imaging	imaging	NOUN
aiua-8854	49	7	at	at	ADP
aiua-8854	49	8	6	6	NUM
aiua-8854	49	9	months	month	NOUN
aiua-8854	49	10	follow	follow	NOUN
aiua-8854	49	11	-	-	PUNCT
aiua-8854	49	12	up	up	NOUN
aiua-8854	49	13	.	.	PUNCT
aiua-8854	50	1	figure	figure	NOUN
aiua-8854	50	2	2	2	NUM
aiua-8854	50	3	.	.	PUNCT
aiua-8854	50	4	bpi	bpi	PROPN
aiua-8854	50	5	trend	trend	NOUN
aiua-8854	50	6	over	over	ADP
aiua-8854	50	7	time	time	NOUN
aiua-8854	50	8	.	.	PUNCT
aiua-8854	51	1	08fantellizzi_stesura	08fantellizzi_stesura	PROPN
aiua-8854	51	2	seveso	seveso	PROPN
aiua-8854	51	3	24/09/20	24/09/20	PROPN
aiua-8854	51	4	14:19	14:19	NUM
aiua-8854	51	5	pagina	pagina	NOUN
aiua-8854	51	6	197	197	NUM
aiua-8854	51	7	archivio	archivio	NOUN
aiua-8854	51	8	italiano	italiano	NOUN
aiua-8854	51	9	di	di	X
aiua-8854	51	10	urologia	urologia	PROPN
aiua-8854	51	11	e	e	PROPN
aiua-8854	51	12	andrologia	andrologia	NOUN
aiua-8854	51	13	2020	2020	NUM
aiua-8854	51	14	;	;	PUNCT
aiua-8854	51	15	92	92	NUM
aiua-8854	51	16	,	,	PUNCT
aiua-8854	51	17	3	3	NUM
aiua-8854	51	18	v.	v.	ADP
aiua-8854	51	19	frantellizzi	frantellizzi	PROPN
aiua-8854	51	20	,	,	PUNCT
aiua-8854	51	21	j.	j.	PROPN
aiua-8854	51	22	lazri	lazri	PROPN
aiua-8854	51	23	,	,	PUNCT
aiua-8854	51	24	m.	m.	NOUN
aiua-8854	51	25	pontico	pontico	PROPN
aiua-8854	51	26	,	,	PUNCT
aiua-8854	51	27	a.	a.	NOUN
aiua-8854	51	28	pani	pani	PROPN
aiua-8854	51	29	,	,	PUNCT
aiua-8854	51	30	g.	g.	PROPN
aiua-8854	51	31	de	de	PROPN
aiua-8854	51	32	vincentis	vincentis	PROPN
aiua-8854	51	33	198	198	NUM
aiua-8854	51	34	discussion	discussion	NOUN
aiua-8854	51	35	in	in	ADP
aiua-8854	51	36	this	this	DET
aiua-8854	51	37	study	study	NOUN
aiua-8854	51	38	,	,	PUNCT
aiua-8854	51	39	we	we	PRON
aiua-8854	51	40	presented	present	VERB
aiua-8854	51	41	the	the	DET
aiua-8854	51	42	case	case	NOUN
aiua-8854	51	43	of	of	ADP
aiua-8854	51	44	an	an	DET
aiua-8854	51	45	mcrpc	mcrpc	NOUN
aiua-8854	51	46	patient	patient	NOUN
aiua-8854	51	47	treated	treat	VERB
aiua-8854	51	48	with	with	ADP
aiua-8854	51	49	radium-223	radium-223	NOUN
aiua-8854	51	50	,	,	PUNCT
aiua-8854	51	51	showing	show	VERB
aiua-8854	51	52	bone	bone	NOUN
aiua-8854	51	53	pain	pain	NOUN
aiua-8854	51	54	reduction	reduction	NOUN
aiua-8854	51	55	during	during	ADP
aiua-8854	51	56	the	the	DET
aiua-8854	51	57	therapy	therapy	NOUN
aiua-8854	51	58	which	which	PRON
aiua-8854	51	59	continued	continue	VERB
aiua-8854	51	60	with	with	ADP
aiua-8854	51	61	a	a	DET
aiua-8854	51	62	further	further	ADJ
aiua-8854	51	63	decline	decline	NOUN
aiua-8854	51	64	for	for	ADP
aiua-8854	51	65	the	the	DET
aiua-8854	51	66	next	next	ADJ
aiua-8854	51	67	3	3	NUM
aiua-8854	51	68	months	month	NOUN
aiua-8854	51	69	after	after	ADP
aiua-8854	51	70	the	the	DET
aiua-8854	51	71	end	end	NOUN
aiua-8854	51	72	treatment	treatment	NOUN
aiua-8854	51	73	.	.	PUNCT
aiua-8854	52	1	nevertheless	nevertheless	ADV
aiua-8854	52	2	,	,	PUNCT
aiua-8854	52	3	after	after	ADP
aiua-8854	52	4	6	6	NUM
aiua-8854	52	5	months	month	NOUN
aiua-8854	52	6	from	from	ADP
aiua-8854	52	7	radium-223	radium-223	NOUN
aiua-8854	52	8	treatment	treatment	NOUN
aiua-8854	52	9	,	,	PUNCT
aiua-8854	52	10	bpi	bpi	PROPN
aiua-8854	52	11	suddenly	suddenly	ADV
aiua-8854	52	12	increased	increase	VERB
aiua-8854	52	13	from	from	ADP
aiua-8854	52	14	2	2	NUM
aiua-8854	52	15	to	to	ADP
aiua-8854	52	16	10	10	NUM
aiua-8854	52	17	with	with	ADP
aiua-8854	52	18	the	the	DET
aiua-8854	52	19	radiological	radiological	ADJ
aiua-8854	52	20	progression	progression	NOUN
aiua-8854	52	21	of	of	ADP
aiua-8854	52	22	disease	disease	NOUN
aiua-8854	52	23	described	describe	VERB
aiua-8854	52	24	in	in	ADP
aiua-8854	52	25	several	several	ADJ
aiua-8854	52	26	bone	bone	NOUN
aiua-8854	52	27	districts	district	NOUN
aiua-8854	52	28	,	,	PUNCT
aiua-8854	52	29	revealed	reveal	VERB
aiua-8854	52	30	with	with	ADP
aiua-8854	52	31	bone	bone	NOUN
aiua-8854	52	32	scan	scan	NOUN
aiua-8854	52	33	.	.	PUNCT
aiua-8854	53	1	the	the	DET
aiua-8854	53	2	phase	phase	NOUN
aiua-8854	53	3	3	3	NUM
aiua-8854	53	4	trial	trial	NOUN
aiua-8854	53	5	alsympca	alsympca	NOUN
aiua-8854	53	6	showed	show	VERB
aiua-8854	53	7	a	a	DET
aiua-8854	53	8	significant	significant	ADJ
aiua-8854	53	9	effect	effect	NOUN
aiua-8854	53	10	of	of	ADP
aiua-8854	53	11	radium-223	radium-223	NOUN
aiua-8854	53	12	on	on	ADP
aiua-8854	53	13	os	os	NOUN
aiua-8854	53	14	and	and	CCONJ
aiua-8854	53	15	a	a	DET
aiua-8854	53	16	delay	delay	NOUN
aiua-8854	53	17	in	in	ADP
aiua-8854	53	18	median	median	ADJ
aiua-8854	53	19	time	time	NOUN
aiua-8854	53	20	to	to	ADP
aiua-8854	53	21	the	the	DET
aiua-8854	53	22	first	first	ADJ
aiua-8854	53	23	sre	sre	NOUN
aiua-8854	53	24	(	(	PUNCT
aiua-8854	53	25	21	21	NUM
aiua-8854	53	26	)	)	PUNCT
aiua-8854	53	27	.	.	PUNCT
aiua-8854	54	1	in	in	ADP
aiua-8854	54	2	the	the	DET
aiua-8854	54	3	meantime	meantime	NOUN
aiua-8854	54	4	,	,	PUNCT
aiua-8854	54	5	several	several	ADJ
aiua-8854	54	6	retrospective	retrospective	ADJ
aiua-8854	54	7	studies	study	NOUN
aiua-8854	54	8	reported	report	VERB
aiua-8854	54	9	a	a	DET
aiua-8854	54	10	difference	difference	NOUN
aiua-8854	54	11	in	in	ADP
aiua-8854	54	12	median	median	PROPN
aiua-8854	54	13	os	os	NOUN
aiua-8854	54	14	between	between	ADP
aiua-8854	54	15	patients	patient	NOUN
aiua-8854	54	16	who	who	PRON
aiua-8854	54	17	received	receive	VERB
aiua-8854	54	18	1	1	NUM
aiua-8854	54	19	to	to	ADP
aiua-8854	54	20	4	4	NUM
aiua-8854	54	21	versus	versus	ADP
aiua-8854	54	22	5	5	NUM
aiua-8854	54	23	to	to	PART
aiua-8854	54	24	6	6	NUM
aiua-8854	54	25	injections	injection	NOUN
aiua-8854	54	26	,	,	PUNCT
aiua-8854	54	27	demonstrating	demonstrate	VERB
aiua-8854	54	28	that	that	SCONJ
aiua-8854	54	29	a	a	DET
aiua-8854	54	30	higher	high	ADJ
aiua-8854	54	31	number	number	NOUN
aiua-8854	54	32	of	of	ADP
aiua-8854	54	33	radium-223	radium-223	NOUN
aiua-8854	54	34	injections	injection	NOUN
aiua-8854	54	35	was	be	AUX
aiua-8854	54	36	associated	associate	VERB
aiua-8854	54	37	with	with	ADP
aiua-8854	54	38	prolonged	prolong	VERB
aiua-8854	54	39	os	os	NOUN
aiua-8854	54	40	(	(	PUNCT
aiua-8854	54	41	median	median	PROPN
aiua-8854	54	42	os	os	NOUN
aiua-8854	54	43	of	of	ADP
aiua-8854	54	44	6.2	6.2	NUM
aiua-8854	54	45	months	month	NOUN
aiua-8854	54	46	,	,	PUNCT
aiua-8854	54	47	versus	versus	ADP
aiua-8854	54	48	17.9	17.9	NUM
aiua-8854	54	49	months	month	NOUN
aiua-8854	54	50	)	)	PUNCT
aiua-8854	54	51	(	(	PUNCT
aiua-8854	54	52	22	22	NUM
aiua-8854	54	53	)	)	PUNCT
aiua-8854	54	54	.	.	PUNCT
aiua-8854	55	1	alsympca	alsympca	PROPN
aiua-8854	55	2	show	show	VERB
aiua-8854	55	3	furthermore	furthermore	ADV
aiua-8854	55	4	that	that	SCONJ
aiua-8854	55	5	radium-223	radium-223	NOUN
aiua-8854	55	6	patients	patient	NOUN
aiua-8854	55	7	reduced	reduce	VERB
aiua-8854	55	8	the	the	DET
aiua-8854	55	9	risk	risk	NOUN
aiua-8854	55	10	of	of	ADP
aiua-8854	55	11	need	need	NOUN
aiua-8854	55	12	for	for	ADP
aiua-8854	55	13	ebrt	ebrt	ADJ
aiua-8854	55	14	for	for	ADP
aiua-8854	55	15	bone	bone	NOUN
aiua-8854	55	16	pain	pain	NOUN
aiua-8854	55	17	and	and	CCONJ
aiua-8854	55	18	notably	notably	ADV
aiua-8854	55	19	delayed	delay	VERB
aiua-8854	55	20	the	the	DET
aiua-8854	55	21	time	time	NOUN
aiua-8854	55	22	to	to	PART
aiua-8854	55	23	first	first	ADJ
aiua-8854	55	24	use	use	NOUN
aiua-8854	55	25	of	of	ADP
aiua-8854	55	26	opioids	opioid	NOUN
aiua-8854	55	27	(	(	PUNCT
aiua-8854	55	28	23	23	NUM
aiua-8854	55	29	)	)	PUNCT
aiua-8854	55	30	.	.	PUNCT
aiua-8854	56	1	this	this	PRON
aiua-8854	56	2	is	be	AUX
aiua-8854	56	3	associated	associate	VERB
aiua-8854	56	4	with	with	ADP
aiua-8854	56	5	significant	significant	ADJ
aiua-8854	56	6	palliation	palliation	NOUN
aiua-8854	56	7	of	of	ADP
aiua-8854	56	8	bone	bone	NOUN
aiua-8854	56	9	pain	pain	NOUN
aiua-8854	56	10	by	by	ADP
aiua-8854	56	11	the	the	DET
aiua-8854	56	12	radiopharmaceutical	radiopharmaceutical	NOUN
aiua-8854	56	13	.	.	PUNCT
aiua-8854	57	1	however	however	ADV
aiua-8854	57	2	,	,	PUNCT
aiua-8854	57	3	alsympca	alsympca	PROPN
aiua-8854	57	4	was	be	AUX
aiua-8854	57	5	not	not	PART
aiua-8854	57	6	planned	plan	VERB
aiua-8854	57	7	to	to	PART
aiua-8854	57	8	evaluate	evaluate	VERB
aiua-8854	57	9	the	the	DET
aiua-8854	57	10	effect	effect	NOUN
aiua-8854	57	11	of	of	ADP
aiua-8854	57	12	radium-223	radium-223	NOUN
aiua-8854	57	13	on	on	ADP
aiua-8854	57	14	pain	pain	NOUN
aiua-8854	57	15	;	;	PUNCT
aiua-8854	57	16	any	any	DET
aiua-8854	57	17	response	response	NOUN
aiua-8854	57	18	to	to	PART
aiua-8854	57	19	pain	pain	NOUN
aiua-8854	57	20	observed	observed	ADJ
aiua-8854	57	21	or	or	CCONJ
aiua-8854	57	22	lack	lack	NOUN
aiua-8854	57	23	of	of	ADP
aiua-8854	57	24	it	it	PRON
aiua-8854	57	25	was	be	AUX
aiua-8854	57	26	not	not	PART
aiua-8854	57	27	considered	consider	VERB
aiua-8854	57	28	a	a	DET
aiua-8854	57	29	reason	reason	NOUN
aiua-8854	57	30	to	to	PART
aiua-8854	57	31	stop	stop	VERB
aiua-8854	57	32	treatment	treatment	NOUN
aiua-8854	57	33	with	with	ADP
aiua-8854	57	34	radium-223	radium-223	NOUN
aiua-8854	57	35	.	.	PUNCT
aiua-8854	58	1	the	the	DET
aiua-8854	58	2	effect	effect	NOUN
aiua-8854	58	3	of	of	ADP
aiua-8854	58	4	treatment	treatment	NOUN
aiua-8854	58	5	on	on	ADP
aiua-8854	58	6	pain	pain	NOUN
aiua-8854	58	7	was	be	AUX
aiua-8854	58	8	not	not	PART
aiua-8854	58	9	systematically	systematically	ADV
aiua-8854	58	10	documented	document	VERB
aiua-8854	58	11	as	as	SCONJ
aiua-8854	58	12	it	it	PRON
aiua-8854	58	13	was	be	AUX
aiua-8854	58	14	not	not	PART
aiua-8854	58	15	one	one	NUM
aiua-8854	58	16	of	of	ADP
aiua-8854	58	17	the	the	DET
aiua-8854	58	18	objectives	objective	NOUN
aiua-8854	58	19	of	of	ADP
aiua-8854	58	20	the	the	DET
aiua-8854	58	21	study	study	NOUN
aiua-8854	58	22	.	.	PUNCT
aiua-8854	59	1	currently	currently	ADV
aiua-8854	59	2	,	,	PUNCT
aiua-8854	59	3	patients	patient	NOUN
aiua-8854	59	4	receive	receive	VERB
aiua-8854	59	5	up	up	ADP
aiua-8854	59	6	to	to	PART
aiua-8854	59	7	six	six	NUM
aiua-8854	59	8	intravenous	intravenous	ADJ
aiua-8854	59	9	injections	injection	NOUN
aiua-8854	59	10	of	of	ADP
aiua-8854	59	11	radium-223	radium-223	NOUN
aiua-8854	59	12	,	,	PUNCT
aiua-8854	59	13	55	55	NUM
aiua-8854	59	14	kbq	kbq	NOUN
aiua-8854	59	15	/	/	SYM
aiua-8854	59	16	kg	kg	PROPN
aiua-8854	59	17	in	in	ADP
aiua-8854	59	18	4	4	NUM
aiua-8854	59	19	-	-	PUNCT
aiua-8854	59	20	week	week	NOUN
aiua-8854	59	21	intervals	interval	NOUN
aiua-8854	59	22	.	.	PUNCT
aiua-8854	60	1	there	there	PRON
aiua-8854	60	2	have	have	AUX
aiua-8854	60	3	been	be	AUX
aiua-8854	60	4	recent	recent	ADJ
aiua-8854	60	5	studies	study	NOUN
aiua-8854	60	6	of	of	ADP
aiua-8854	60	7	retreatment	retreatment	NOUN
aiua-8854	60	8	with	with	ADP
aiua-8854	60	9	radium-223	radium-223	NOUN
aiua-8854	60	10	(	(	PUNCT
aiua-8854	60	11	24	24	NUM
aiua-8854	60	12	)	)	PUNCT
aiua-8854	60	13	.	.	PUNCT
aiua-8854	61	1	one	one	NUM
aiua-8854	61	2	of	of	ADP
aiua-8854	61	3	these	these	PRON
aiua-8854	61	4	is	be	AUX
aiua-8854	61	5	the	the	DET
aiua-8854	61	6	open	open	ADJ
aiua-8854	61	7	-	-	PUNCT
aiua-8854	61	8	label	label	NOUN
aiua-8854	61	9	,	,	PUNCT
aiua-8854	61	10	phase	phase	NOUN
aiua-8854	61	11	1/2	1/2	NUM
aiua-8854	61	12	study	study	NOUN
aiua-8854	61	13	(	(	PUNCT
aiua-8854	61	14	nct01934790	nct01934790	NOUN
aiua-8854	61	15	)	)	PUNCT
aiua-8854	61	16	(	(	PUNCT
aiua-8854	61	17	25	25	NUM
aiua-8854	61	18	)	)	PUNCT
aiua-8854	61	19	.	.	PUNCT
aiua-8854	62	1	this	this	DET
aiua-8854	62	2	study	study	NOUN
aiua-8854	62	3	,	,	PUNCT
aiua-8854	62	4	including	include	VERB
aiua-8854	62	5	44	44	NUM
aiua-8854	62	6	patients	patient	NOUN
aiua-8854	62	7	with	with	ADP
aiua-8854	62	8	no	no	DET
aiua-8854	62	9	disease	disease	NOUN
aiua-8854	62	10	progression	progression	NOUN
aiua-8854	62	11	in	in	ADP
aiua-8854	62	12	bone	bone	NOUN
aiua-8854	62	13	during	during	ADP
aiua-8854	62	14	the	the	DET
aiua-8854	62	15	first	first	ADJ
aiua-8854	62	16	treatment	treatment	NOUN
aiua-8854	62	17	and	and	CCONJ
aiua-8854	62	18	presence	presence	NOUN
aiua-8854	62	19	of	of	ADP
aiua-8854	62	20	later	later	ADJ
aiua-8854	62	21	progression	progression	NOUN
aiua-8854	62	22	,	,	PUNCT
aiua-8854	62	23	that	that	PRON
aiua-8854	62	24	received	receive	VERB
aiua-8854	62	25	radium-223	radium-223	NOUN
aiua-8854	62	26	re	re	NOUN
aiua-8854	62	27	-	-	NOUN
aiua-8854	62	28	treatment	treatment	NOUN
aiua-8854	62	29	,	,	PUNCT
aiua-8854	62	30	up	up	ADV
aiua-8854	62	31	to	to	PART
aiua-8854	62	32	6	6	NUM
aiua-8854	62	33	additional	additional	ADJ
aiua-8854	62	34	radium-223	radium-223	NOUN
aiua-8854	62	35	injections	injection	NOUN
aiua-8854	62	36	,	,	PUNCT
aiua-8854	62	37	showed	show	VERB
aiua-8854	62	38	that	that	SCONJ
aiua-8854	62	39	retreatment	retreatment	NOUN
aiua-8854	62	40	with	with	ADP
aiua-8854	62	41	radium-223	radium-223	NOUN
aiua-8854	62	42	was	be	AUX
aiua-8854	62	43	well	well	ADV
aiua-8854	62	44	tolerated	tolerate	VERB
aiua-8854	62	45	with	with	ADP
aiua-8854	62	46	favorable	favorable	ADJ
aiua-8854	62	47	effects	effect	NOUN
aiua-8854	62	48	on	on	ADP
aiua-8854	62	49	disease	disease	NOUN
aiua-8854	62	50	progression	progression	NOUN
aiua-8854	62	51	.	.	PUNCT
aiua-8854	63	1	another	another	DET
aiua-8854	63	2	ongoing	ongoing	ADJ
aiua-8854	63	3	phase	phase	NOUN
aiua-8854	63	4	ii	ii	PROPN
aiua-8854	63	5	study	study	NOUN
aiua-8854	63	6	(	(	PUNCT
aiua-8854	63	7	nct02023697	nct02023697	ADV
aiua-8854	63	8	)	)	PUNCT
aiua-8854	63	9	evaluated	evaluate	VERB
aiua-8854	63	10	standard	standard	PROPN
aiua-8854	63	11	dose	dose	NOUN
aiua-8854	63	12	(	(	PUNCT
aiua-8854	63	13	55	55	NUM
aiua-8854	63	14	kbq	kbq	PROPN
aiua-8854	63	15	/	/	SYM
aiua-8854	63	16	kg	kg	PROPN
aiua-8854	63	17	every	every	DET
aiua-8854	63	18	4	4	NUM
aiua-8854	63	19	weeks	week	NOUN
aiua-8854	63	20	up	up	ADP
aiua-8854	63	21	to	to	PART
aiua-8854	63	22	6	6	NUM
aiua-8854	63	23	injections	injection	NOUN
aiua-8854	63	24	)	)	PUNCT
aiua-8854	63	25	versus	versus	ADP
aiua-8854	63	26	high	high	ADJ
aiua-8854	63	27	dose	dose	NOUN
aiua-8854	63	28	(	(	PUNCT
aiua-8854	63	29	88	88	NUM
aiua-8854	63	30	kbq	kbq	NOUN
aiua-8854	63	31	/	/	SYM
aiua-8854	63	32	kg	kg	PROPN
aiua-8854	63	33	every	every	DET
aiua-8854	63	34	4	4	NUM
aiua-8854	63	35	weeks	week	NOUN
aiua-8854	63	36	up	up	ADP
aiua-8854	63	37	to	to	PART
aiua-8854	63	38	6	6	NUM
aiua-8854	63	39	injections	injection	NOUN
aiua-8854	63	40	)	)	PUNCT
aiua-8854	63	41	and	and	CCONJ
aiua-8854	63	42	versus	versus	ADP
aiua-8854	63	43	extended	extended	ADJ
aiua-8854	63	44	standard	standard	NOUN
aiua-8854	63	45	dose	dose	NOUN
aiua-8854	63	46	(	(	PUNCT
aiua-8854	63	47	55	55	NUM
aiua-8854	63	48	kbq	kbq	PROPN
aiua-8854	63	49	/	/	SYM
aiua-8854	63	50	kg	kg	PROPN
aiua-8854	64	1	every	every	DET
aiua-8854	64	2	4	4	NUM
aiua-8854	64	3	weeks	week	NOUN
aiua-8854	64	4	up	up	ADP
aiua-8854	64	5	to	to	ADP
aiua-8854	64	6	12	12	NUM
aiua-8854	64	7	injections	injection	NOUN
aiua-8854	64	8	)	)	PUNCT
aiua-8854	64	9	(	(	PUNCT
aiua-8854	64	10	26	26	NUM
aiua-8854	64	11	,	,	PUNCT
aiua-8854	64	12	27	27	NUM
aiua-8854	64	13	)	)	PUNCT
aiua-8854	64	14	.	.	PUNCT
aiua-8854	65	1	in	in	ADP
aiua-8854	65	2	literature	literature	NOUN
aiua-8854	65	3	has	have	AUX
aiua-8854	65	4	been	be	AUX
aiua-8854	65	5	already	already	ADV
aiua-8854	65	6	showed	show	VERB
aiua-8854	65	7	how	how	SCONJ
aiua-8854	65	8	radium-223	radium-223	NOUN
aiua-8854	65	9	could	could	AUX
aiua-8854	65	10	significantly	significantly	ADV
aiua-8854	65	11	extend	extend	VERB
aiua-8854	65	12	os	os	ADV
aiua-8854	65	13	,	,	PUNCT
aiua-8854	65	14	associated	associate	VERB
aiua-8854	65	15	with	with	ADP
aiua-8854	65	16	a	a	DET
aiua-8854	65	17	delay	delay	NOUN
aiua-8854	65	18	in	in	ADP
aiua-8854	65	19	median	median	ADJ
aiua-8854	65	20	time	time	NOUN
aiua-8854	65	21	to	to	ADP
aiua-8854	65	22	the	the	DET
aiua-8854	65	23	first	first	ADJ
aiua-8854	65	24	symptomatic	symptomatic	ADJ
aiua-8854	65	25	sre	sre	NOUN
aiua-8854	65	26	,	,	PUNCT
aiua-8854	65	27	meaningful	meaningful	ADJ
aiua-8854	65	28	improvement	improvement	NOUN
aiua-8854	65	29	in	in	ADP
aiua-8854	65	30	qol	qol	NOUN
aiua-8854	65	31	and	and	CCONJ
aiua-8854	65	32	bone	bone	NOUN
aiua-8854	65	33	pain	pain	NOUN
aiua-8854	65	34	palliation	palliation	NOUN
aiua-8854	65	35	(	(	PUNCT
aiua-8854	65	36	23	23	NUM
aiua-8854	65	37	,	,	PUNCT
aiua-8854	65	38	28	28	NUM
aiua-8854	65	39	)	)	PUNCT
aiua-8854	65	40	.	.	PUNCT
aiua-8854	66	1	several	several	ADJ
aiua-8854	66	2	trials	trial	NOUN
aiua-8854	66	3	showed	show	VERB
aiua-8854	66	4	that	that	SCONJ
aiua-8854	66	5	radium-223	radium-223	NOUN
aiua-8854	66	6	is	be	AUX
aiua-8854	66	7	well	well	ADV
aiua-8854	66	8	tolerated	tolerate	VERB
aiua-8854	66	9	and	and	CCONJ
aiua-8854	66	10	has	have	VERB
aiua-8854	66	11	a	a	DET
aiua-8854	66	12	favorable	favorable	ADJ
aiua-8854	66	13	hematologic	hematologic	NOUN
aiua-8854	66	14	safety	safety	NOUN
aiua-8854	66	15	profile	profile	NOUN
aiua-8854	66	16	(	(	PUNCT
aiua-8854	66	17	29	29	NUM
aiua-8854	66	18	)	)	PUNCT
aiua-8854	66	19	,	,	PUNCT
aiua-8854	66	20	with	with	ADP
aiua-8854	66	21	a	a	DET
aiua-8854	66	22	low	low	ADJ
aiua-8854	66	23	incidence	incidence	NOUN
aiua-8854	66	24	of	of	ADP
aiua-8854	66	25	myelosuppression	myelosuppression	NOUN
aiua-8854	66	26	(	(	PUNCT
aiua-8854	66	27	30	30	NUM
aiua-8854	66	28	)	)	PUNCT
aiua-8854	66	29	.	.	PUNCT
aiua-8854	67	1	such	such	ADJ
aiua-8854	67	2	safety	safety	NOUN
aiua-8854	67	3	is	be	AUX
aiua-8854	67	4	confirmed	confirm	VERB
aiua-8854	67	5	from	from	ADP
aiua-8854	67	6	long	long	ADJ
aiua-8854	67	7	-	-	PUNCT
aiua-8854	67	8	term	term	NOUN
aiua-8854	67	9	safety	safety	NOUN
aiua-8854	67	10	alsympca	alsympca	NOUN
aiua-8854	67	11	analysis	analysis	NOUN
aiua-8854	67	12	up	up	ADP
aiua-8854	67	13	to	to	PART
aiua-8854	67	14	3	3	NUM
aiua-8854	67	15	years	year	NOUN
aiua-8854	67	16	from	from	ADP
aiua-8854	67	17	first	first	ADJ
aiua-8854	67	18	injection	injection	NOUN
aiua-8854	67	19	,	,	PUNCT
aiua-8854	67	20	which	which	PRON
aiua-8854	67	21	indicated	indicate	VERB
aiua-8854	67	22	that	that	SCONJ
aiua-8854	67	23	radium-223	radium-223	NOUN
aiua-8854	67	24	remained	remained	AUX
aiua-8854	67	25	still	still	ADV
aiua-8854	67	26	well	well	ADV
aiua-8854	67	27	tolerated	tolerate	VERB
aiua-8854	67	28	,	,	PUNCT
aiua-8854	67	29	with	with	ADP
aiua-8854	67	30	low	low	ADJ
aiua-8854	67	31	myelosuppression	myelosuppression	NOUN
aiua-8854	67	32	incidence	incidence	NOUN
aiua-8854	67	33	and	and	CCONJ
aiua-8854	67	34	no	no	DET
aiua-8854	67	35	new	new	ADJ
aiua-8854	67	36	safety	safety	NOUN
aiua-8854	67	37	concerns	concern	NOUN
aiua-8854	67	38	(	(	PUNCT
aiua-8854	67	39	31	31	NUM
aiua-8854	67	40	)	)	PUNCT
aiua-8854	67	41	.	.	PUNCT
aiua-8854	68	1	it	it	PRON
aiua-8854	68	2	is	be	AUX
aiua-8854	68	3	possible	possible	ADJ
aiua-8854	68	4	to	to	PART
aiua-8854	68	5	postulate	postulate	VERB
aiua-8854	68	6	that	that	SCONJ
aiua-8854	68	7	some	some	DET
aiua-8854	68	8	patients	patient	NOUN
aiua-8854	68	9	after	after	ADP
aiua-8854	68	10	initial	initial	ADJ
aiua-8854	68	11	treatment	treatment	NOUN
aiua-8854	68	12	may	may	AUX
aiua-8854	68	13	derive	derive	VERB
aiua-8854	68	14	benefit	benefit	NOUN
aiua-8854	68	15	from	from	ADP
aiua-8854	68	16	extended	extend	VERB
aiua-8854	68	17	treatment	treatment	NOUN
aiua-8854	68	18	with	with	ADP
aiua-8854	68	19	radium-223	radium-223	NOUN
aiua-8854	68	20	.	.	PUNCT
aiua-8854	69	1	the	the	DET
aiua-8854	69	2	open	open	ADJ
aiua-8854	69	3	-	-	PUNCT
aiua-8854	69	4	label	label	NOUN
aiua-8854	69	5	,	,	PUNCT
aiua-8854	69	6	phase	phase	NOUN
aiua-8854	69	7	1/2	1/2	NUM
aiua-8854	69	8	nct01934790	nct01934790	NOUN
aiua-8854	69	9	trial	trial	NOUN
aiua-8854	69	10	(	(	PUNCT
aiua-8854	69	11	25	25	NUM
aiua-8854	69	12	)	)	PUNCT
aiua-8854	69	13	showed	show	VERB
aiua-8854	69	14	that	that	SCONJ
aiua-8854	69	15	re	re	NOUN
aiua-8854	69	16	-	-	NOUN
aiua-8854	69	17	treatment	treatment	NOUN
aiua-8854	69	18	with	with	ADP
aiua-8854	69	19	radium-223	radium-223	NOUN
aiua-8854	69	20	sustained	sustain	VERB
aiua-8854	69	21	benefit	benefit	NOUN
aiua-8854	69	22	on	on	ADP
aiua-8854	69	23	disease	disease	NOUN
aiua-8854	69	24	and	and	CCONJ
aiua-8854	69	25	progression	progression	NOUN
aiua-8854	69	26	was	be	AUX
aiua-8854	69	27	well	well	ADV
aiua-8854	69	28	tolerated	tolerate	VERB
aiua-8854	69	29	.	.	PUNCT
aiua-8854	70	1	in	in	ADP
aiua-8854	70	2	particular	particular	ADJ
aiua-8854	70	3	,	,	PUNCT
aiua-8854	70	4	it	it	PRON
aiua-8854	70	5	showed	show	VERB
aiua-8854	70	6	a	a	DET
aiua-8854	70	7	low	low	ADJ
aiua-8854	70	8	incidence	incidence	NOUN
aiua-8854	70	9	of	of	ADP
aiua-8854	70	10	clinical	clinical	ADJ
aiua-8854	70	11	events	event	NOUN
aiua-8854	70	12	such	such	ADJ
aiua-8854	70	13	as	as	ADP
aiua-8854	70	14	symptomatic	symptomatic	ADJ
aiua-8854	70	15	sre	sre	NOUN
aiua-8854	70	16	or	or	CCONJ
aiua-8854	70	17	radiographic	radiographic	ADJ
aiua-8854	70	18	bone	bone	NOUN
aiua-8854	70	19	progression	progression	NOUN
aiua-8854	70	20	.	.	PUNCT
aiua-8854	71	1	furthermore	furthermore	ADV
aiua-8854	71	2	,	,	PUNCT
aiua-8854	71	3	in	in	ADP
aiua-8854	71	4	this	this	DET
aiua-8854	71	5	study	study	NOUN
aiua-8854	71	6	talp	talp	NOUN
aiua-8854	71	7	declined	decline	VERB
aiua-8854	71	8	from	from	ADP
aiua-8854	71	9	baseline	baseline	ADJ
aiua-8854	71	10	values	value	NOUN
aiua-8854	71	11	after	after	ADP
aiua-8854	71	12	re	re	NOUN
aiua-8854	71	13	-	-	NOUN
aiua-8854	71	14	treatment	treatment	NOUN
aiua-8854	71	15	,	,	PUNCT
aiua-8854	71	16	suggesting	suggest	VERB
aiua-8854	71	17	a	a	DET
aiua-8854	71	18	continuation	continuation	NOUN
aiua-8854	71	19	of	of	ADP
aiua-8854	71	20	the	the	DET
aiua-8854	71	21	biologic	biologic	NOUN
aiua-8854	71	22	effects	effect	NOUN
aiua-8854	71	23	of	of	ADP
aiua-8854	71	24	radium-223	radium-223	NOUN
aiua-8854	71	25	;	;	PUNCT
aiua-8854	71	26	moreover	moreover	ADV
aiua-8854	71	27	,	,	PUNCT
aiua-8854	71	28	the	the	DET
aiua-8854	71	29	median	median	PROPN
aiua-8854	71	30	os	os	NOUN
aiua-8854	71	31	increased	increase	VERB
aiua-8854	71	32	to	to	ADP
aiua-8854	71	33	24.4	24.4	NUM
aiua-8854	71	34	months	month	NOUN
aiua-8854	71	35	at	at	ADP
aiua-8854	71	36	the	the	DET
aiua-8854	71	37	end	end	NOUN
aiua-8854	71	38	of	of	ADP
aiua-8854	71	39	the	the	DET
aiua-8854	71	40	2	2	NUM
aiua-8854	71	41	-	-	PUNCT
aiua-8854	71	42	year	year	NOUN
aiua-8854	71	43	active	active	ADJ
aiua-8854	71	44	follow	follow	NOUN
aiua-8854	71	45	-	-	PUNCT
aiua-8854	71	46	up	up	NOUN
aiua-8854	71	47	period	period	NOUN
aiua-8854	71	48	.	.	PUNCT
aiua-8854	72	1	a	a	DET
aiua-8854	72	2	further	further	ADJ
aiua-8854	72	3	study	study	NOUN
aiua-8854	72	4	focused	focus	VERB
aiua-8854	72	5	on	on	ADP
aiua-8854	72	6	these	these	DET
aiua-8854	72	7	patients	patient	NOUN
aiua-8854	72	8	confirms	confirm	VERB
aiua-8854	72	9	its	its	PRON
aiua-8854	72	10	safety	safety	NOUN
aiua-8854	72	11	in	in	ADP
aiua-8854	72	12	a	a	DET
aiua-8854	72	13	2	2	NUM
aiua-8854	72	14	-	-	PUNCT
aiua-8854	72	15	year	year	NOUN
aiua-8854	72	16	active	active	ADJ
aiua-8854	72	17	follow	follow	NOUN
aiua-8854	72	18	-	-	PUNCT
aiua-8854	72	19	up	up	ADP
aiua-8854	72	20	analysis	analysis	NOUN
aiua-8854	72	21	,	,	PUNCT
aiua-8854	72	22	especially	especially	ADV
aiua-8854	72	23	with	with	ADP
aiua-8854	72	24	regards	regard	NOUN
aiua-8854	72	25	to	to	ADP
aiua-8854	72	26	the	the	DET
aiua-8854	72	27	minimal	minimal	ADJ
aiua-8854	72	28	hematologic	hematologic	NOUN
aiua-8854	72	29	toxicity	toxicity	NOUN
aiua-8854	72	30	and	and	CCONJ
aiua-8854	72	31	efficacy	efficacy	NOUN
aiua-8854	72	32	outcome	outcome	NOUN
aiua-8854	72	33	from	from	ADP
aiua-8854	72	34	2	2	NUM
aiua-8854	72	35	-	-	PUNCT
aiua-8854	72	36	year	year	NOUN
aiua-8854	72	37	follow	follow	NOUN
aiua-8854	72	38	-	-	PUNCT
aiua-8854	72	39	up	up	NOUN
aiua-8854	72	40	of	of	ADP
aiua-8854	72	41	the	the	DET
aiua-8854	72	42	retreatment	retreatment	NOUN
aiua-8854	72	43	with	with	ADP
aiua-8854	72	44	radium-223	radium-223	NOUN
aiua-8854	72	45	.	.	PUNCT
aiua-8854	73	1	in	in	ADP
aiua-8854	73	2	view	view	NOUN
aiua-8854	73	3	of	of	ADP
aiua-8854	73	4	these	these	DET
aiua-8854	73	5	remarkable	remarkable	ADJ
aiua-8854	73	6	results	result	NOUN
aiua-8854	73	7	and	and	CCONJ
aiua-8854	73	8	based	base	VERB
aiua-8854	73	9	on	on	ADP
aiua-8854	73	10	our	our	PRON
aiua-8854	73	11	wide	wide	ADJ
aiua-8854	73	12	experience	experience	NOUN
aiua-8854	73	13	,	,	PUNCT
aiua-8854	73	14	we	we	PRON
aiua-8854	73	15	could	could	AUX
aiua-8854	73	16	reasonably	reasonably	ADV
aiua-8854	73	17	assume	assume	VERB
aiua-8854	73	18	that	that	SCONJ
aiua-8854	73	19	this	this	DET
aiua-8854	73	20	patient	patient	NOUN
aiua-8854	73	21	would	would	AUX
aiua-8854	73	22	have	have	AUX
aiua-8854	73	23	provided	provide	VERB
aiua-8854	73	24	clinical	clinical	ADJ
aiua-8854	73	25	benefits	benefit	NOUN
aiua-8854	73	26	if	if	SCONJ
aiua-8854	73	27	he	he	PRON
aiua-8854	73	28	continued	continue	VERB
aiua-8854	73	29	the	the	DET
aiua-8854	73	30	radium-223	radium-223	NOUN
aiua-8854	73	31	therapy	therapy	NOUN
aiua-8854	73	32	.	.	PUNCT
aiua-8854	74	1	conclusions	conclusion	NOUN
aiua-8854	74	2	further	further	ADJ
aiua-8854	74	3	analysis	analysis	NOUN
aiua-8854	74	4	should	should	AUX
aiua-8854	74	5	be	be	AUX
aiua-8854	74	6	conducted	conduct	VERB
aiua-8854	74	7	on	on	ADP
aiua-8854	74	8	a	a	DET
aiua-8854	74	9	large	large	ADJ
aiua-8854	74	10	cohort	cohort	NOUN
aiua-8854	74	11	to	to	PART
aiua-8854	74	12	evaluate	evaluate	VERB
aiua-8854	74	13	the	the	DET
aiua-8854	74	14	clinical	clinical	ADJ
aiua-8854	74	15	outcome	outcome	NOUN
aiua-8854	74	16	in	in	ADP
aiua-8854	74	17	terms	term	NOUN
aiua-8854	74	18	of	of	ADP
aiua-8854	74	19	bone	bone	NOUN
aiua-8854	74	20	pain	pain	NOUN
aiua-8854	74	21	palliation	palliation	NOUN
aiua-8854	74	22	after	after	ADP
aiua-8854	74	23	radium-223	radium-223	NOUN
aiua-8854	74	24	treatment	treatment	NOUN
aiua-8854	74	25	and	and	CCONJ
aiua-8854	74	26	the	the	DET
aiua-8854	74	27	possibility	possibility	NOUN
aiua-8854	74	28	,	,	PUNCT
aiua-8854	74	29	considering	consider	VERB
aiua-8854	74	30	the	the	DET
aiua-8854	74	31	low	low	ADJ
aiua-8854	74	32	toxicity	toxicity	NOUN
aiua-8854	74	33	profile	profile	NOUN
aiua-8854	74	34	,	,	PUNCT
aiua-8854	74	35	of	of	ADP
aiua-8854	74	36	re	re	NOUN
aiua-8854	74	37	-	-	NOUN
aiua-8854	74	38	treatment	treatment	NOUN
aiua-8854	74	39	in	in	ADP
aiua-8854	74	40	selected	select	VERB
aiua-8854	74	41	patients	patient	NOUN
aiua-8854	74	42	.	.	PUNCT
aiua-8854	75	1	ethical	ethical	ADJ
aiua-8854	75	2	approval	approval	NOUN
aiua-8854	75	3	this	this	DET
aiua-8854	75	4	study	study	NOUN
aiua-8854	75	5	has	have	AUX
aiua-8854	75	6	been	be	AUX
aiua-8854	75	7	approved	approve	VERB
aiua-8854	75	8	by	by	ADP
aiua-8854	75	9	the	the	DET
aiua-8854	75	10	local	local	ADJ
aiua-8854	75	11	ethical	ethical	ADJ
aiua-8854	75	12	committee	committee	NOUN
aiua-8854	75	13	.	.	PUNCT
aiua-8854	76	1	all	all	DET
aiua-8854	76	2	procedures	procedure	NOUN
aiua-8854	76	3	performed	perform	VERB
aiua-8854	76	4	in	in	ADP
aiua-8854	76	5	studies	study	NOUN
aiua-8854	76	6	involving	involve	VERB
aiua-8854	76	7	human	human	ADJ
aiua-8854	76	8	participants	participant	NOUN
aiua-8854	76	9	were	be	AUX
aiua-8854	76	10	in	in	ADP
aiua-8854	76	11	accordance	accordance	NOUN
aiua-8854	76	12	with	with	ADP
aiua-8854	76	13	the	the	DET
aiua-8854	76	14	ethical	ethical	ADJ
aiua-8854	76	15	standards	standard	NOUN
aiua-8854	76	16	of	of	ADP
aiua-8854	76	17	the	the	DET
aiua-8854	76	18	institutional	institutional	ADJ
aiua-8854	76	19	and/or	and/or	CCONJ
aiua-8854	76	20	national	national	PROPN
aiua-8854	76	21	research	research	PROPN
aiua-8854	76	22	committee	committee	NOUN
aiua-8854	76	23	and	and	CCONJ
aiua-8854	76	24	with	with	ADP
aiua-8854	76	25	the	the	DET
aiua-8854	76	26	1964	1964	NUM
aiua-8854	76	27	helsinki	helsinki	PROPN
aiua-8854	76	28	declaration	declaration	PROPN
aiua-8854	76	29	and	and	CCONJ
aiua-8854	76	30	its	its	PRON
aiua-8854	76	31	later	later	ADJ
aiua-8854	76	32	amendments	amendment	NOUN
aiua-8854	76	33	or	or	CCONJ
aiua-8854	76	34	comparable	comparable	ADJ
aiua-8854	76	35	ethical	ethical	ADJ
aiua-8854	76	36	standards	standard	NOUN
aiua-8854	76	37	.	.	PUNCT
aiua-8854	77	1	informed	informed	ADJ
aiua-8854	77	2	consent	consent	NOUN
aiua-8854	77	3	informed	informed	ADJ
aiua-8854	77	4	consent	consent	NOUN
aiua-8854	77	5	was	be	AUX
aiua-8854	77	6	obtained	obtain	VERB
aiua-8854	77	7	from	from	ADP
aiua-8854	77	8	all	all	DET
aiua-8854	77	9	individual	individual	ADJ
aiua-8854	77	10	participants	participant	NOUN
aiua-8854	77	11	included	include	VERB
aiua-8854	77	12	in	in	ADP
aiua-8854	77	13	the	the	DET
aiua-8854	77	14	study	study	NOUN
aiua-8854	77	15	.	.	PUNCT
aiua-8854	78	1	research	research	NOUN
aiua-8854	78	2	involving	involve	VERB
aiua-8854	78	3	human	human	ADJ
aiua-8854	78	4	participants	participant	NOUN
aiua-8854	78	5	and/or	and/or	CCONJ
aiua-8854	78	6	animals	animal	NOUN
aiua-8854	78	7	this	this	DET
aiua-8854	78	8	article	article	NOUN
aiua-8854	78	9	does	do	AUX
aiua-8854	78	10	not	not	PART
aiua-8854	78	11	contain	contain	VERB
aiua-8854	78	12	any	any	DET
aiua-8854	78	13	studies	study	NOUN
aiua-8854	78	14	with	with	ADP
aiua-8854	78	15	animals	animal	NOUN
aiua-8854	78	16	performed	perform	VERB
aiua-8854	78	17	by	by	ADP
aiua-8854	78	18	any	any	PRON
aiua-8854	78	19	of	of	ADP
aiua-8854	78	20	the	the	DET
aiua-8854	78	21	authors	author	NOUN
aiua-8854	78	22	.	.	PUNCT
aiua-8854	79	1	references	reference	NOUN
aiua-8854	79	2	1	1	NUM
aiua-8854	79	3	.	.	PUNCT
aiua-8854	79	4	siegel	siegel	PROPN
aiua-8854	79	5	rl	rl	PROPN
aiua-8854	79	6	,	,	PUNCT
aiua-8854	79	7	miller	miller	PROPN
aiua-8854	79	8	kd	kd	PROPN
aiua-8854	79	9	,	,	PUNCT
aiua-8854	79	10	jemal	jemal	ADJ
aiua-8854	79	11	a.	a.	NOUN
aiua-8854	79	12	cancer	cancer	PROPN
aiua-8854	79	13	statistics	statistic	NOUN
aiua-8854	79	14	,	,	PUNCT
aiua-8854	79	15	2016	2016	NUM
aiua-8854	79	16	.	.	PUNCT
aiua-8854	80	1	ca	can	AUX
aiua-8854	80	2	cancer	cancer	PROPN
aiua-8854	80	3	j	j	PROPN
aiua-8854	80	4	clin	clin	PROPN
aiua-8854	80	5	.	.	PUNCT
aiua-8854	81	1	2016	2016	NUM
aiua-8854	81	2	;	;	PUNCT
aiua-8854	81	3	66:7	66:7	NOUN
aiua-8854	81	4	-	-	SYM
aiua-8854	81	5	30	30	NUM
aiua-8854	81	6	.	.	PUNCT
aiua-8854	82	1	2	2	NUM
aiua-8854	82	2	.	.	X
aiua-8854	82	3	santer	santer	PROPN
aiua-8854	82	4	fr	fr	PROPN
aiua-8854	82	5	,	,	PUNCT
aiua-8854	82	6	erb	erb	NOUN
aiua-8854	82	7	hh	hh	PROPN
aiua-8854	82	8	,	,	PUNCT
aiua-8854	82	9	mcneill	mcneill	PROPN
aiua-8854	82	10	rv	rv	PROPN
aiua-8854	82	11	.	.	PUNCT
aiua-8854	83	1	therapy	therapy	NOUN
aiua-8854	83	2	escape	escape	NOUN
aiua-8854	83	3	mechanisms	mechanism	NOUN
aiua-8854	83	4	in	in	ADP
aiua-8854	83	5	the	the	DET
aiua-8854	83	6	malignant	malignant	ADJ
aiua-8854	83	7	prostate	prostate	NOUN
aiua-8854	83	8	.	.	PUNCT
aiua-8854	84	1	semin	semin	PROPN
aiua-8854	84	2	cancer	cancer	PROPN
aiua-8854	84	3	biol	biol	PROPN
aiua-8854	84	4	.	.	PUNCT
aiua-8854	85	1	2015	2015	NUM
aiua-8854	85	2	;	;	PUNCT
aiua-8854	85	3	35:133	35:133	NUM
aiua-8854	85	4	-	-	SYM
aiua-8854	85	5	44	44	NUM
aiua-8854	85	6	.	.	PUNCT
aiua-8854	86	1	3	3	X
aiua-8854	86	2	.	.	X
aiua-8854	86	3	sciarra	sciarra	PROPN
aiua-8854	86	4	a	a	DET
aiua-8854	86	5	,	,	PUNCT
aiua-8854	86	6	gentilucci	gentilucci	NOUN
aiua-8854	86	7	a	a	NOUN
aiua-8854	86	8	,	,	PUNCT
aiua-8854	86	9	silvestri	silvestri	PROPN
aiua-8854	86	10	i	i	PRON
aiua-8854	86	11	,	,	PUNCT
aiua-8854	86	12	et	et	PROPN
aiua-8854	86	13	al	al	PROPN
aiua-8854	86	14	.	.	PUNCT
aiua-8854	86	15	androgen	androgen	NOUN
aiua-8854	86	16	receptor	receptor	NOUN
aiua-8854	86	17	variant	variant	NOUN
aiua-8854	86	18	7	7	NUM
aiua-8854	86	19	(	(	PUNCT
aiua-8854	86	20	ar	ar	NOUN
aiua-8854	86	21	-	-	PUNCT
aiua-8854	86	22	v7	v7	NOUN
aiua-8854	86	23	)	)	PUNCT
aiua-8854	86	24	in	in	ADP
aiua-8854	86	25	sequencing	sequence	VERB
aiua-8854	86	26	therapeutic	therapeutic	ADJ
aiua-8854	86	27	agents	agent	NOUN
aiua-8854	86	28	for	for	ADP
aiua-8854	86	29	castratrion	castratrion	NOUN
aiua-8854	86	30	resistant	resistant	ADJ
aiua-8854	86	31	prostate	prostate	NOUN
aiua-8854	86	32	cancer	cancer	NOUN
aiua-8854	86	33	:	:	PUNCT
aiua-8854	86	34	a	a	DET
aiua-8854	86	35	critical	critical	ADJ
aiua-8854	86	36	review	review	NOUN
aiua-8854	86	37	.	.	PUNCT
aiua-8854	87	1	medicine	medicine	NOUN
aiua-8854	87	2	(	(	PUNCT
aiua-8854	87	3	baltimore	baltimore	PROPN
aiua-8854	87	4	)	)	PUNCT
aiua-8854	87	5	2019	2019	NUM
aiua-8854	87	6	;	;	PUNCT
aiua-8854	87	7	98	98	NUM
aiua-8854	87	8	:	:	PUNCT
aiua-8854	87	9	e15608	e15608	ADJ
aiua-8854	87	10	.	.	PUNCT
aiua-8854	88	1	4	4	X
aiua-8854	88	2	.	.	X
aiua-8854	88	3	ricci	ricci	PROPN
aiua-8854	88	4	m	m	PROPN
aiua-8854	88	5	,	,	PUNCT
aiua-8854	88	6	frantellizzi	frantellizzi	NOUN
aiua-8854	88	7	v	v	NOUN
aiua-8854	88	8	,	,	PUNCT
aiua-8854	88	9	bulzonetti	bulzonetti	NOUN
aiua-8854	88	10	n	n	PRON
aiua-8854	88	11	,	,	PUNCT
aiua-8854	88	12	de	de	X
aiua-8854	88	13	vincentis	vincentis	PROPN
aiua-8854	88	14	g.	g.	PROPN
aiua-8854	88	15	reversibility	reversibility	NOUN
aiua-8854	88	16	of	of	ADP
aiua-8854	88	17	castration	castration	NOUN
aiua-8854	88	18	resistance	resistance	NOUN
aiua-8854	88	19	status	status	NOUN
aiua-8854	88	20	after	after	ADP
aiua-8854	88	21	radium-223	radium-223	VERB
aiua-8854	88	22	dichloride	dichloride	NOUN
aiua-8854	88	23	treatment	treatment	NOUN
aiua-8854	88	24	:	:	PUNCT
aiua-8854	88	25	clinical	clinical	ADJ
aiua-8854	88	26	evidence	evidence	NOUN
aiua-8854	88	27	and	and	CCONJ
aiua-8854	88	28	review	review	NOUN
aiua-8854	88	29	of	of	ADP
aiua-8854	88	30	the	the	DET
aiua-8854	88	31	literature	literature	NOUN
aiua-8854	88	32	.	.	PUNCT
aiua-8854	89	1	int	int	PROPN
aiua-8854	89	2	j	j	PROPN
aiua-8854	89	3	radiat	radiat	PROPN
aiua-8854	89	4	biol	biol	PROPN
aiua-8854	89	5	.	.	PUNCT
aiua-8854	90	1	2019	2019	NUM
aiua-8854	90	2	;	;	PUNCT
aiua-8854	90	3	95:554	95:554	NUM
aiua-8854	90	4	-	-	SYM
aiua-8854	90	5	561	561	NUM
aiua-8854	90	6	.	.	PUNCT
aiua-8854	91	1	5	5	NUM
aiua-8854	91	2	.	.	X
aiua-8854	91	3	cornford	cornford	PROPN
aiua-8854	91	4	p	p	X
aiua-8854	91	5	,	,	PUNCT
aiua-8854	91	6	bellmunt	bellmunt	PROPN
aiua-8854	91	7	j	j	PROPN
aiua-8854	91	8	,	,	PUNCT
aiua-8854	91	9	bolla	bolla	PROPN
aiua-8854	91	10	m	m	PROPN
aiua-8854	91	11	,	,	PUNCT
aiua-8854	91	12	et	et	PROPN
aiua-8854	91	13	al	al	PROPN
aiua-8854	91	14	.	.	PUNCT
aiua-8854	92	1	eau	eau	PROPN
aiua-8854	92	2	-	-	PUNCT
aiua-8854	92	3	estro	estro	NOUN
aiua-8854	92	4	-	-	PUNCT
aiua-8854	92	5	siog	siog	NOUN
aiua-8854	92	6	guidelines	guideline	NOUN
aiua-8854	92	7	on	on	ADP
aiua-8854	92	8	prostate	prostate	NOUN
aiua-8854	92	9	cancer	cancer	NOUN
aiua-8854	92	10	.	.	PUNCT
aiua-8854	93	1	part	part	NOUN
aiua-8854	93	2	ii	ii	PROPN
aiua-8854	93	3	:	:	PUNCT
aiua-8854	93	4	treatment	treatment	NOUN
aiua-8854	93	5	of	of	ADP
aiua-8854	93	6	relapsing	relapse	VERB
aiua-8854	93	7	,	,	PUNCT
aiua-8854	93	8	metastatic	metastatic	ADJ
aiua-8854	93	9	,	,	PUNCT
aiua-8854	93	10	and	and	CCONJ
aiua-8854	93	11	castration	castration	NOUN
aiua-8854	93	12	-	-	PUNCT
aiua-8854	93	13	resistant	resistant	ADJ
aiua-8854	93	14	prostate	prostate	NOUN
aiua-8854	93	15	cancer	cancer	NOUN
aiua-8854	93	16	.	.	PUNCT
aiua-8854	94	1	eur	eur	PROPN
aiua-8854	94	2	urol	urol	PROPN
aiua-8854	94	3	.	.	PROPN
aiua-8854	95	1	2017	2017	NUM
aiua-8854	95	2	;	;	PUNCT
aiua-8854	95	3	71:630	71:630	NUM
aiua-8854	95	4	-	-	SYM
aiua-8854	95	5	42	42	NUM
aiua-8854	95	6	.	.	PUNCT
aiua-8854	96	1	6	6	NUM
aiua-8854	96	2	.	.	X
aiua-8854	96	3	lowrance	lowrance	PROPN
aiua-8854	96	4	wt	wt	PROPN
aiua-8854	96	5	,	,	PUNCT
aiua-8854	96	6	roth	roth	NOUN
aiua-8854	96	7	bj	bj	NOUN
aiua-8854	96	8	,	,	PUNCT
aiua-8854	96	9	kirkby	kirkby	NOUN
aiua-8854	96	10	e	e	NOUN
aiua-8854	96	11	,	,	PUNCT
aiua-8854	96	12	et	et	PROPN
aiua-8854	96	13	al	al	PROPN
aiua-8854	96	14	.	.	PUNCT
aiua-8854	96	15	castration	castration	NOUN
aiua-8854	96	16	-	-	PUNCT
aiua-8854	96	17	resistant	resistant	ADJ
aiua-8854	96	18	prostate	prostate	NOUN
aiua-8854	96	19	cancer	cancer	NOUN
aiua-8854	96	20	:	:	PUNCT
aiua-8854	96	21	aua	aua	PROPN
aiua-8854	96	22	guideline	guideline	PROPN
aiua-8854	96	23	amendment	amendment	PROPN
aiua-8854	96	24	2015	2015	NUM
aiua-8854	96	25	.	.	PUNCT
aiua-8854	97	1	j	j	PROPN
aiua-8854	97	2	urol	urol	PROPN
aiua-8854	97	3	.	.	PROPN
aiua-8854	97	4	2016	2016	NUM
aiua-8854	97	5	;	;	PUNCT
aiua-8854	97	6	195:1444	195:1444	NUM
aiua-8854	97	7	-	-	SYM
aiua-8854	97	8	52	52	NUM
aiua-8854	97	9	.	.	PUNCT
aiua-8854	98	1	08fantellizzi_stesura	08fantellizzi_stesura	PROPN
aiua-8854	98	2	seveso	seveso	PROPN
aiua-8854	98	3	24/09/20	24/09/20	PROPN
aiua-8854	98	4	14:19	14:19	NUM
aiua-8854	98	5	pagina	pagina	NOUN
aiua-8854	98	6	198	198	NUM
aiua-8854	98	7	199archivio	199archivio	PROPN
aiua-8854	98	8	italiano	italiano	NOUN
aiua-8854	98	9	di	di	NOUN
aiua-8854	98	10	urologia	urologia	PROPN
aiua-8854	98	11	e	e	PROPN
aiua-8854	98	12	andrologia	andrologia	NOUN
aiua-8854	98	13	2020	2020	NUM
aiua-8854	98	14	;	;	PUNCT
aiua-8854	98	15	92	92	NUM
aiua-8854	98	16	,	,	PUNCT
aiua-8854	98	17	3	3	NUM
aiua-8854	98	18	bone	bone	NOUN
aiua-8854	98	19	pain	pain	NOUN
aiua-8854	98	20	palliation	palliation	NOUN
aiua-8854	98	21	and	and	CCONJ
aiua-8854	98	22	radium-223	radium-223	NOUN
aiua-8854	98	23	re	re	NOUN
aiua-8854	98	24	-	-	NOUN
aiua-8854	98	25	treatment	treatment	NOUN
aiua-8854	98	26	7	7	NUM
aiua-8854	98	27	.	.	PUNCT
aiua-8854	98	28	sathiakumar	sathiakumar	PROPN
aiua-8854	98	29	n	n	CCONJ
aiua-8854	98	30	,	,	PUNCT
aiua-8854	98	31	delzell	delzell	NOUN
aiua-8854	98	32	e	e	PROPN
aiua-8854	98	33	,	,	PUNCT
aiua-8854	98	34	morrisey	morrisey	PROPN
aiua-8854	98	35	ma	ma	PROPN
aiua-8854	98	36	,	,	PUNCT
aiua-8854	98	37	et	et	PROPN
aiua-8854	98	38	al	al	PROPN
aiua-8854	98	39	.	.	PUNCT
aiua-8854	99	1	mortality	mortality	NOUN
aiua-8854	99	2	following	follow	VERB
aiua-8854	99	3	bone	bone	NOUN
aiua-8854	99	4	metastasis	metastasis	NOUN
aiua-8854	99	5	and	and	CCONJ
aiua-8854	99	6	skeletal	skeletal	ADJ
aiua-8854	99	7	-	-	PUNCT
aiua-8854	99	8	related	relate	VERB
aiua-8854	99	9	events	event	NOUN
aiua-8854	99	10	among	among	ADP
aiua-8854	99	11	men	man	NOUN
aiua-8854	99	12	with	with	ADP
aiua-8854	99	13	prostate	prostate	NOUN
aiua-8854	99	14	cancer	cancer	NOUN
aiua-8854	99	15	:	:	PUNCT
aiua-8854	99	16	a	a	DET
aiua-8854	99	17	population	population	NOUN
aiua-8854	99	18	-	-	PUNCT
aiua-8854	99	19	based	base	VERB
aiua-8854	99	20	analysis	analysis	NOUN
aiua-8854	99	21	of	of	ADP
aiua-8854	99	22	us	us	PROPN
aiua-8854	99	23	medicare	medicare	PROPN
aiua-8854	99	24	beneficiaries	beneficiary	NOUN
aiua-8854	99	25	,	,	PUNCT
aiua-8854	99	26	1999	1999	NUM
aiua-8854	99	27	-	-	SYM
aiua-8854	99	28	2006	2006	NUM
aiua-8854	99	29	.	.	PUNCT
aiua-8854	100	1	prostate	prostate	NOUN
aiua-8854	100	2	cancer	cancer	NOUN
aiua-8854	100	3	prostatic	prostatic	ADJ
aiua-8854	100	4	dis	dis	PROPN
aiua-8854	100	5	.	.	PUNCT
aiua-8854	101	1	2011	2011	NUM
aiua-8854	101	2	;	;	PUNCT
aiua-8854	101	3	14:177	14:177	NUM
aiua-8854	101	4	-	-	SYM
aiua-8854	101	5	83	83	NUM
aiua-8854	101	6	.	.	NOUN
aiua-8854	102	1	8	8	NUM
aiua-8854	102	2	.	.	PUNCT
aiua-8854	103	1	som	som	NOUN
aiua-8854	103	2	a	a	PROPN
aiua-8854	103	3	,	,	PUNCT
aiua-8854	103	4	tu	tu	PROPN
aiua-8854	103	5	sm	sm	PROPN
aiua-8854	103	6	,	,	PUNCT
aiua-8854	103	7	liu	liu	PROPN
aiua-8854	103	8	,	,	PUNCT
aiua-8854	103	9	et	et	PROPN
aiua-8854	103	10	al	al	PROPN
aiua-8854	103	11	.	.	PROPN
aiua-8854	103	12	response	response	NOUN
aiua-8854	103	13	in	in	ADP
aiua-8854	103	14	bone	bone	NOUN
aiua-8854	103	15	turnover	turnover	NOUN
aiua-8854	103	16	markers	marker	NOUN
aiua-8854	103	17	during	during	ADP
aiua-8854	103	18	therapy	therapy	NOUN
aiua-8854	103	19	predicts	predict	VERB
aiua-8854	103	20	overall	overall	ADJ
aiua-8854	103	21	survival	survival	NOUN
aiua-8854	103	22	in	in	ADP
aiua-8854	103	23	patients	patient	NOUN
aiua-8854	103	24	with	with	ADP
aiua-8854	103	25	metastatic	metastatic	ADJ
aiua-8854	103	26	prostate	prostate	NOUN
aiua-8854	103	27	cancer	cancer	NOUN
aiua-8854	103	28	:	:	PUNCT
aiua-8854	103	29	analysis	analysis	NOUN
aiua-8854	103	30	of	of	ADP
aiua-8854	103	31	three	three	NUM
aiua-8854	103	32	clinical	clinical	ADJ
aiua-8854	103	33	trials	trial	NOUN
aiua-8854	103	34	.	.	PUNCT
aiua-8854	104	1	br	br	PROPN
aiua-8854	104	2	j	j	PROPN
aiua-8854	104	3	cancer	cancer	NOUN
aiua-8854	104	4	.	.	PUNCT
aiua-8854	105	1	2012	2012	NUM
aiua-8854	105	2	;	;	PUNCT
aiua-8854	105	3	107:1547	107:1547	NUM
aiua-8854	105	4	-	-	SYM
aiua-8854	105	5	53	53	NUM
aiua-8854	105	6	.	.	NOUN
aiua-8854	106	1	9	9	NUM
aiua-8854	106	2	.	.	X
aiua-8854	106	3	smith	smith	PROPN
aiua-8854	106	4	hs	hs	PROPN
aiua-8854	106	5	.	.	PUNCT
aiua-8854	106	6	painful	painful	ADJ
aiua-8854	106	7	osseous	osseous	ADJ
aiua-8854	106	8	metastases	metastasis	NOUN
aiua-8854	106	9	.	.	PUNCT
aiua-8854	107	1	pain	pain	NOUN
aiua-8854	107	2	physician	physician	NOUN
aiua-8854	107	3	2011	2011	NUM
aiua-8854	107	4	;	;	PUNCT
aiua-8854	107	5	14	14	NUM
aiua-8854	107	6	:	:	PUNCT
aiua-8854	107	7	e373	e373	PROPN
aiua-8854	107	8	-	-	PUNCT
aiua-8854	107	9	403	403	NUM
aiua-8854	107	10	.	.	PUNCT
aiua-8854	108	1	10	10	NUM
aiua-8854	108	2	.	.	X
aiua-8854	108	3	de	de	PROPN
aiua-8854	108	4	vincentis	vincentis	PROPN
aiua-8854	108	5	g	g	PROPN
aiua-8854	108	6	,	,	PUNCT
aiua-8854	108	7	frantellizzi	frantellizzi	NOUN
aiua-8854	108	8	v	v	NOUN
aiua-8854	108	9	,	,	PUNCT
aiua-8854	108	10	follacchio	follacchio	PROPN
aiua-8854	108	11	ga	ga	PROPN
aiua-8854	108	12	,	,	PUNCT
aiua-8854	108	13	et	et	PROPN
aiua-8854	108	14	al	al	PROPN
aiua-8854	108	15	.	.	PUNCT
aiua-8854	109	1	no	no	DET
aiua-8854	109	2	evidence	evidence	NOUN
aiua-8854	109	3	of	of	ADP
aiua-8854	109	4	association	association	NOUN
aiua-8854	109	5	between	between	ADP
aiua-8854	109	6	psychological	psychological	ADJ
aiua-8854	109	7	distress	distress	NOUN
aiua-8854	109	8	and	and	CCONJ
aiua-8854	109	9	pain	pain	NOUN
aiua-8854	109	10	relief	relief	NOUN
aiua-8854	109	11	in	in	ADP
aiua-8854	109	12	patients	patient	NOUN
aiua-8854	109	13	with	with	ADP
aiua-8854	109	14	bone	bone	NOUN
aiua-8854	109	15	metastases	metastasis	NOUN
aiua-8854	109	16	from	from	ADP
aiua-8854	109	17	castration	castration	NOUN
aiua-8854	109	18	-	-	PUNCT
aiua-8854	109	19	resistant	resistant	ADJ
aiua-8854	109	20	prostate	prostate	NOUN
aiua-8854	109	21	cancer	cancer	NOUN
aiua-8854	109	22	treated	treat	VERB
aiua-8854	109	23	with	with	ADP
aiua-8854	109	24	223radium	223radium	PROPN
aiua-8854	109	25	.	.	PUNCT
aiua-8854	109	26	eur	eur	PROPN
aiua-8854	109	27	j	j	PROPN
aiua-8854	109	28	cancer	cancer	NOUN
aiua-8854	109	29	care	care	NOUN
aiua-8854	109	30	(	(	PUNCT
aiua-8854	109	31	engl	engl	PROPN
aiua-8854	109	32	)	)	PUNCT
aiua-8854	109	33	2019	2019	NUM
aiua-8854	109	34	;	;	PUNCT
aiua-8854	109	35	28	28	NUM
aiua-8854	109	36	:	:	PUNCT
aiua-8854	109	37	e13112	e13112	ADJ
aiua-8854	109	38	.	.	PUNCT
aiua-8854	110	1	11	11	NUM
aiua-8854	110	2	.	.	X
aiua-8854	110	3	de	de	PROPN
aiua-8854	110	4	vincentis	vincentis	PROPN
aiua-8854	110	5	g	g	PROPN
aiua-8854	110	6	,	,	PUNCT
aiua-8854	110	7	monari	monari	PROPN
aiua-8854	110	8	f	f	AUX
aiua-8854	110	9	,	,	PUNCT
aiua-8854	110	10	baldari	baldari	PROPN
aiua-8854	110	11	s	s	PROPN
aiua-8854	110	12	,	,	PUNCT
aiua-8854	110	13	et	et	PROPN
aiua-8854	110	14	al	al	PROPN
aiua-8854	110	15	.	.	PROPN
aiua-8854	110	16	narrative	narrative	ADJ
aiua-8854	110	17	medicine	medicine	NOUN
aiua-8854	110	18	in	in	ADP
aiua-8854	110	19	metastatic	metastatic	ADJ
aiua-8854	110	20	prostate	prostate	NOUN
aiua-8854	110	21	cancer	cancer	NOUN
aiua-8854	110	22	reveals	reveal	VERB
aiua-8854	110	23	ways	way	NOUN
aiua-8854	110	24	to	to	PART
aiua-8854	110	25	improve	improve	VERB
aiua-8854	110	26	patient	patient	ADJ
aiua-8854	110	27	awareness	awareness	NOUN
aiua-8854	110	28	&	&	CCONJ
aiua-8854	110	29	quality	quality	NOUN
aiua-8854	110	30	of	of	ADP
aiua-8854	110	31	care	care	NOUN
aiua-8854	110	32	.	.	PUNCT
aiua-8854	111	1	future	future	ADJ
aiua-8854	111	2	oncology	oncology	NOUN
aiua-8854	111	3	(	(	PUNCT
aiua-8854	111	4	london	london	PROPN
aiua-8854	111	5	,	,	PUNCT
aiua-8854	111	6	england	england	PROPN
aiua-8854	111	7	)	)	PUNCT
aiua-8854	111	8	2018	2018	NUM
aiua-8854	111	9	;	;	PUNCT
aiua-8854	111	10	14:2821	14:2821	NUM
aiua-8854	111	11	-	-	SYM
aiua-8854	111	12	32	32	NUM
aiua-8854	111	13	.	.	PUNCT
aiua-8854	112	1	12	12	NUM
aiua-8854	112	2	.	.	PUNCT
aiua-8854	113	1	asselah	asselah	PROPN
aiua-8854	113	2	j	j	PROPN
aiua-8854	113	3	,	,	PUNCT
aiua-8854	113	4	sperlich	sperlich	PROPN
aiua-8854	113	5	c.	c.	PROPN
aiua-8854	113	6	post	post	PROPN
aiua-8854	113	7	-	-	ADJ
aiua-8854	113	8	docetaxel	docetaxel	ADJ
aiua-8854	113	9	options	option	NOUN
aiua-8854	113	10	for	for	ADP
aiua-8854	113	11	further	further	ADJ
aiua-8854	113	12	survival	survival	NOUN
aiua-8854	113	13	benefit	benefit	NOUN
aiua-8854	113	14	in	in	ADP
aiua-8854	113	15	metastatic	metastatic	ADJ
aiua-8854	113	16	castration	castration	NOUN
aiua-8854	113	17	-	-	PUNCT
aiua-8854	113	18	resistant	resistant	ADJ
aiua-8854	113	19	prostate	prostate	NOUN
aiua-8854	113	20	cancer	cancer	NOUN
aiua-8854	113	21	:	:	PUNCT
aiua-8854	113	22	questions	question	NOUN
aiua-8854	113	23	of	of	ADP
aiua-8854	113	24	choice	choice	NOUN
aiua-8854	113	25	.	.	PUNCT
aiua-8854	114	1	can	can	AUX
aiua-8854	114	2	urol	urol	VERB
aiua-8854	114	3	assoc	assoc	PROPN
aiua-8854	114	4	j.	j.	PROPN
aiua-8854	114	5	2013	2013	NUM
aiua-8854	114	6	;	;	PUNCT
aiua-8854	114	7	7	7	NUM
aiua-8854	114	8	:	:	PUNCT
aiua-8854	114	9	s11	s11	NUM
aiua-8854	114	10	-	-	PUNCT
aiua-8854	114	11	7	7	NUM
aiua-8854	114	12	.	.	NOUN
aiua-8854	114	13	13	13	NUM
aiua-8854	114	14	.	.	PUNCT
aiua-8854	115	1	heidenreich	heidenreich	PRON
aiua-8854	115	2	a	a	DET
aiua-8854	115	3	,	,	PUNCT
aiua-8854	115	4	bastian	bastian	PROPN
aiua-8854	115	5	pj	pj	PROPN
aiua-8854	115	6	,	,	PUNCT
aiua-8854	115	7	bellmunt	bellmunt	PROPN
aiua-8854	115	8	j	j	PROPN
aiua-8854	115	9	,	,	PUNCT
aiua-8854	115	10	et	et	PROPN
aiua-8854	115	11	al	al	PROPN
aiua-8854	115	12	.	.	PUNCT
aiua-8854	116	1	eau	eau	PROPN
aiua-8854	116	2	guidelines	guideline	NOUN
aiua-8854	116	3	on	on	ADP
aiua-8854	116	4	prostate	prostate	NOUN
aiua-8854	116	5	cancer	cancer	NOUN
aiua-8854	116	6	.	.	PUNCT
aiua-8854	117	1	part	part	NOUN
aiua-8854	117	2	ii	ii	PROPN
aiua-8854	117	3	:	:	PUNCT
aiua-8854	117	4	treatment	treatment	NOUN
aiua-8854	117	5	of	of	ADP
aiua-8854	117	6	advanced	advanced	ADJ
aiua-8854	117	7	,	,	PUNCT
aiua-8854	117	8	relapsing	relapse	VERB
aiua-8854	117	9	,	,	PUNCT
aiua-8854	117	10	and	and	CCONJ
aiua-8854	117	11	castration	castration	NOUN
aiua-8854	117	12	-	-	PUNCT
aiua-8854	117	13	resistant	resistant	ADJ
aiua-8854	117	14	prostate	prostate	NOUN
aiua-8854	117	15	cancer	cancer	NOUN
aiua-8854	117	16	.	.	PUNCT
aiua-8854	118	1	eur	eur	PROPN
aiua-8854	118	2	urol	urol	PROPN
aiua-8854	118	3	.	.	PUNCT
aiua-8854	118	4	2014	2014	NUM
aiua-8854	118	5	;	;	PUNCT
aiua-8854	118	6	65:467	65:467	PROPN
aiua-8854	118	7	-	-	SYM
aiua-8854	118	8	79	79	NUM
aiua-8854	118	9	.	.	PUNCT
aiua-8854	119	1	14	14	NUM
aiua-8854	119	2	.	.	X
aiua-8854	119	3	de	de	PROPN
aiua-8854	119	4	vincentis	vincentis	PROPN
aiua-8854	119	5	g	g	PROPN
aiua-8854	119	6	,	,	PUNCT
aiua-8854	119	7	gerritsen	gerritsen	PROPN
aiua-8854	119	8	w	w	PROPN
aiua-8854	119	9	,	,	PUNCT
aiua-8854	119	10	gschwend	gschwend	PROPN
aiua-8854	119	11	je	je	PROPN
aiua-8854	119	12	,	,	PUNCT
aiua-8854	119	13	et	et	PROPN
aiua-8854	119	14	al	al	PROPN
aiua-8854	119	15	.	.	PROPN
aiua-8854	119	16	advances	advance	NOUN
aiua-8854	119	17	in	in	ADP
aiua-8854	119	18	targeted	target	VERB
aiua-8854	119	19	alpha	alpha	NOUN
aiua-8854	119	20	therapy	therapy	NOUN
aiua-8854	119	21	for	for	ADP
aiua-8854	119	22	prostate	prostate	NOUN
aiua-8854	119	23	cancer	cancer	NOUN
aiua-8854	119	24	.	.	PUNCT
aiua-8854	120	1	ann	ann	PROPN
aiua-8854	120	2	oncol	oncol	PROPN
aiua-8854	120	3	.	.	PUNCT
aiua-8854	121	1	2019	2019	NUM
aiua-8854	121	2	;	;	PUNCT
aiua-8854	121	3	30:1728	30:1728	NUM
aiua-8854	121	4	-	-	SYM
aiua-8854	121	5	1739	1739	NUM
aiua-8854	121	6	.	.	PUNCT
aiua-8854	122	1	15	15	NUM
aiua-8854	122	2	.	.	PUNCT
aiua-8854	123	1	baldari	baldari	PROPN
aiua-8854	123	2	s	s	PROPN
aiua-8854	123	3	,	,	PUNCT
aiua-8854	123	4	boni	boni	PROPN
aiua-8854	123	5	g	g	PROPN
aiua-8854	123	6	,	,	PUNCT
aiua-8854	123	7	bortolus	bortolus	ADJ
aiua-8854	123	8	r	r	NOUN
aiua-8854	123	9	,	,	PUNCT
aiua-8854	123	10	et	et	PROPN
aiua-8854	123	11	al	al	PROPN
aiua-8854	123	12	.	.	PUNCT
aiua-8854	123	13	management	management	NOUN
aiua-8854	123	14	of	of	ADP
aiua-8854	123	15	metastatic	metastatic	ADJ
aiua-8854	123	16	castration	castration	NOUN
aiua-8854	123	17	-	-	PUNCT
aiua-8854	123	18	resistant	resistant	ADJ
aiua-8854	123	19	prostate	prostate	NOUN
aiua-8854	123	20	cancer	cancer	NOUN
aiua-8854	123	21	:	:	PUNCT
aiua-8854	123	22	a	a	DET
aiua-8854	123	23	focus	focus	NOUN
aiua-8854	123	24	on	on	ADP
aiua-8854	123	25	radium-223	radium-223	NOUN
aiua-8854	123	26	:	:	PUNCT
aiua-8854	123	27	opinions	opinion	NOUN
aiua-8854	123	28	and	and	CCONJ
aiua-8854	123	29	suggestions	suggestion	NOUN
aiua-8854	123	30	from	from	ADP
aiua-8854	123	31	an	an	DET
aiua-8854	123	32	expert	expert	ADJ
aiua-8854	123	33	multidisciplinary	multidisciplinary	ADJ
aiua-8854	123	34	panel	panel	NOUN
aiua-8854	123	35	.	.	PUNCT
aiua-8854	124	1	crit	crit	PROPN
aiua-8854	124	2	rev	rev	VERB
aiua-8854	124	3	oncol	oncol	ADJ
aiua-8854	124	4	hematol	hematol	NOUN
aiua-8854	124	5	.	.	PUNCT
aiua-8854	125	1	2017	2017	NUM
aiua-8854	125	2	;	;	PUNCT
aiua-8854	125	3	113:43	113:43	NUM
aiua-8854	125	4	-	-	SYM
aiua-8854	125	5	51	51	NUM
aiua-8854	125	6	.	.	PUNCT
aiua-8854	125	7	16	16	NUM
aiua-8854	125	8	.	.	PUNCT
aiua-8854	126	1	henriksen	henriksen	PROPN
aiua-8854	126	2	g	g	PROPN
aiua-8854	126	3	,	,	PUNCT
aiua-8854	126	4	breistol	breistol	PROPN
aiua-8854	126	5	k	k	PROPN
aiua-8854	126	6	,	,	PUNCT
aiua-8854	126	7	bruland	bruland	NOUN
aiua-8854	126	8	os	os	PROPN
aiua-8854	126	9	,	,	PUNCT
aiua-8854	126	10	et	et	PROPN
aiua-8854	126	11	al	al	PROPN
aiua-8854	126	12	.	.	PUNCT
aiua-8854	127	1	significant	significant	ADJ
aiua-8854	127	2	antitumor	antitumor	PROPN
aiua-8854	127	3	effect	effect	NOUN
aiua-8854	127	4	from	from	ADP
aiua-8854	127	5	bone	bone	NOUN
aiua-8854	127	6	-	-	PUNCT
aiua-8854	127	7	seeking	seeking	NOUN
aiua-8854	127	8	,	,	PUNCT
aiua-8854	127	9	alpha	alpha	NOUN
aiua-8854	127	10	-	-	PUNCT
aiua-8854	127	11	particle	particle	NOUN
aiua-8854	127	12	-	-	PUNCT
aiua-8854	127	13	emitting	emit	VERB
aiua-8854	127	14	(	(	PUNCT
aiua-8854	127	15	223)ra	223)ra	NUM
aiua-8854	127	16	demonstrated	demonstrate	VERB
aiua-8854	127	17	in	in	ADP
aiua-8854	127	18	an	an	DET
aiua-8854	127	19	experimental	experimental	ADJ
aiua-8854	127	20	skeletal	skeletal	ADJ
aiua-8854	127	21	metastases	metastasis	NOUN
aiua-8854	127	22	model	model	NOUN
aiua-8854	127	23	.	.	PUNCT
aiua-8854	128	1	cancer	cancer	NOUN
aiua-8854	128	2	res	re	NOUN
aiua-8854	128	3	.	.	PUNCT
aiua-8854	128	4	2002	2002	NUM
aiua-8854	128	5	;	;	PUNCT
aiua-8854	128	6	62:3120	62:3120	NUM
aiua-8854	128	7	-	-	SYM
aiua-8854	128	8	5	5	NUM
aiua-8854	128	9	.	.	NOUN
aiua-8854	128	10	17	17	NUM
aiua-8854	128	11	.	.	PUNCT
aiua-8854	129	1	du	du	PROPN
aiua-8854	129	2	y	y	PROPN
aiua-8854	129	3	,	,	PUNCT
aiua-8854	129	4	carrio	carrio	NOUN
aiua-8854	129	5	i	i	PRON
aiua-8854	129	6	,	,	PUNCT
aiua-8854	129	7	de	de	PROPN
aiua-8854	129	8	vincentis	vincentis	PROPN
aiua-8854	129	9	g	g	PROPN
aiua-8854	129	10	,	,	PUNCT
aiua-8854	129	11	et	et	PROPN
aiua-8854	129	12	al	al	PROPN
aiua-8854	129	13	.	.	PROPN
aiua-8854	129	14	practical	practical	ADJ
aiua-8854	129	15	recommendations	recommendation	NOUN
aiua-8854	129	16	for	for	ADP
aiua-8854	129	17	radium-223	radium-223	NOUN
aiua-8854	129	18	treatment	treatment	NOUN
aiua-8854	129	19	of	of	ADP
aiua-8854	129	20	metastatic	metastatic	ADJ
aiua-8854	129	21	castration	castration	NOUN
aiua-8854	129	22	-	-	PUNCT
aiua-8854	129	23	resistant	resistant	ADJ
aiua-8854	129	24	prostate	prostate	NOUN
aiua-8854	129	25	cancer	cancer	NOUN
aiua-8854	129	26	.	.	PUNCT
aiua-8854	130	1	eur	eur	PROPN
aiua-8854	130	2	j	j	PROPN
aiua-8854	130	3	nucl	nucl	PROPN
aiua-8854	130	4	med	me	VERB
aiua-8854	130	5	mol	mol	ADP
aiua-8854	130	6	imaging	imaging	PROPN
aiua-8854	130	7	.	.	PUNCT
aiua-8854	131	1	2017	2017	NUM
aiua-8854	131	2	;	;	PUNCT
aiua-8854	131	3	44:1671	44:1671	NUM
aiua-8854	131	4	-	-	SYM
aiua-8854	131	5	8	8	NUM
aiua-8854	131	6	.	.	NUM
aiua-8854	132	1	18	18	NUM
aiua-8854	132	2	.	.	PUNCT
aiua-8854	133	1	o'sullivan	o'sullivan	PROPN
aiua-8854	133	2	jm	jm	PROPN
aiua-8854	133	3	,	,	PUNCT
aiua-8854	133	4	heinrich	heinrich	PROPN
aiua-8854	133	5	d	d	PROPN
aiua-8854	133	6	,	,	PUNCT
aiua-8854	133	7	james	james	PROPN
aiua-8854	133	8	nd	nd	PROPN
aiua-8854	133	9	,	,	PUNCT
aiua-8854	133	10	et	et	PROPN
aiua-8854	133	11	al	al	PROPN
aiua-8854	133	12	.	.	PUNCT
aiua-8854	134	1	the	the	DET
aiua-8854	134	2	case	case	NOUN
aiua-8854	134	3	against	against	ADP
aiua-8854	134	4	the	the	DET
aiua-8854	134	5	european	european	PROPN
aiua-8854	134	6	medicines	medicines	PROPN
aiua-8854	134	7	agency	agency	NOUN
aiua-8854	134	8	's	's	PART
aiua-8854	134	9	change	change	NOUN
aiua-8854	134	10	to	to	ADP
aiua-8854	134	11	the	the	DET
aiua-8854	134	12	label	label	NOUN
aiua-8854	134	13	for	for	ADP
aiua-8854	134	14	radium223	radium223	PROPN
aiua-8854	134	15	for	for	ADP
aiua-8854	134	16	the	the	DET
aiua-8854	134	17	treatment	treatment	NOUN
aiua-8854	134	18	of	of	ADP
aiua-8854	134	19	metastatic	metastatic	ADJ
aiua-8854	134	20	castration	castration	NOUN
aiua-8854	134	21	-	-	PUNCT
aiua-8854	134	22	resistant	resistant	ADJ
aiua-8854	134	23	prostate	prostate	NOUN
aiua-8854	134	24	cancer	cancer	NOUN
aiua-8854	134	25	.	.	PUNCT
aiua-8854	135	1	eur	eur	PROPN
aiua-8854	135	2	urol	urol	PROPN
aiua-8854	135	3	.	.	PUNCT
aiua-8854	136	1	2019	2019	NUM
aiua-8854	136	2	;	;	PUNCT
aiua-8854	136	3	75	75	NUM
aiua-8854	136	4	:	:	PUNCT
aiua-8854	136	5	e51	e51	NOUN
aiua-8854	136	6	-	-	PUNCT
aiua-8854	136	7	e2	e2	PROPN
aiua-8854	136	8	.	.	PUNCT
aiua-8854	137	1	19	19	NUM
aiua-8854	137	2	.	.	PUNCT
aiua-8854	137	3	smith	smith	PROPN
aiua-8854	137	4	m	m	PROPN
aiua-8854	137	5	,	,	PUNCT
aiua-8854	137	6	parker	parker	PROPN
aiua-8854	137	7	c	c	PROPN
aiua-8854	137	8	,	,	PUNCT
aiua-8854	137	9	saad	saad	PROPN
aiua-8854	137	10	f	f	PROPN
aiua-8854	137	11	,	,	PUNCT
aiua-8854	137	12	et	et	PROPN
aiua-8854	137	13	al	al	PROPN
aiua-8854	137	14	.	.	PROPN
aiua-8854	138	1	addition	addition	NOUN
aiua-8854	138	2	of	of	ADP
aiua-8854	138	3	radium-223	radium-223	NOUN
aiua-8854	138	4	to	to	ADP
aiua-8854	138	5	abiraterone	abiraterone	NOUN
aiua-8854	138	6	acetate	acetate	NOUN
aiua-8854	138	7	and	and	CCONJ
aiua-8854	138	8	prednisone	prednisone	PROPN
aiua-8854	138	9	or	or	CCONJ
aiua-8854	138	10	prednisolone	prednisolone	PROPN
aiua-8854	138	11	in	in	ADP
aiua-8854	138	12	patients	patient	NOUN
aiua-8854	138	13	with	with	ADP
aiua-8854	138	14	castration	castration	NOUN
aiua-8854	138	15	-	-	PUNCT
aiua-8854	138	16	resistant	resistant	ADJ
aiua-8854	138	17	prostate	prostate	NOUN
aiua-8854	138	18	cancer	cancer	NOUN
aiua-8854	138	19	and	and	CCONJ
aiua-8854	138	20	bone	bone	NOUN
aiua-8854	138	21	metastases	metastasis	NOUN
aiua-8854	138	22	(	(	PUNCT
aiua-8854	138	23	era	era	NOUN
aiua-8854	138	24	223	223	NUM
aiua-8854	138	25	):	):	PUNCT
aiua-8854	138	26	a	a	DET
aiua-8854	138	27	randomised	randomised	ADJ
aiua-8854	138	28	,	,	PUNCT
aiua-8854	138	29	double	double	ADJ
aiua-8854	138	30	-	-	PUNCT
aiua-8854	138	31	blind	blind	ADJ
aiua-8854	138	32	,	,	PUNCT
aiua-8854	138	33	placebo	placebo	NOUN
aiua-8854	138	34	-	-	PUNCT
aiua-8854	138	35	controlled	control	VERB
aiua-8854	138	36	,	,	PUNCT
aiua-8854	138	37	phase	phase	NOUN
aiua-8854	138	38	3	3	NUM
aiua-8854	138	39	trial	trial	NOUN
aiua-8854	138	40	.	.	PUNCT
aiua-8854	139	1	the	the	DET
aiua-8854	139	2	lancet	lancet	PROPN
aiua-8854	139	3	.	.	PUNCT
aiua-8854	140	1	oncology	oncology	NOUN
aiua-8854	140	2	.	.	PUNCT
aiua-8854	141	1	2019	2019	NUM
aiua-8854	141	2	;	;	PUNCT
aiua-8854	141	3	20:408	20:408	NUM
aiua-8854	141	4	-	-	SYM
aiua-8854	141	5	19	19	NUM
aiua-8854	141	6	.	.	NOUN
aiua-8854	141	7	20	20	NUM
aiua-8854	141	8	.	.	PUNCT
aiua-8854	142	1	saad	saad	PROPN
aiua-8854	142	2	f	f	PROPN
aiua-8854	142	3	,	,	PUNCT
aiua-8854	142	4	gillessen	gillessen	PROPN
aiua-8854	142	5	s	s	PROPN
aiua-8854	142	6	,	,	PUNCT
aiua-8854	142	7	heinrich	heinrich	NOUN
aiua-8854	142	8	d	d	PROPN
aiua-8854	142	9	,	,	PUNCT
aiua-8854	142	10	et	et	PROPN
aiua-8854	142	11	al	al	PROPN
aiua-8854	142	12	.	.	PROPN
aiua-8854	142	13	disease	disease	PROPN
aiua-8854	142	14	characteristics	characteristic	NOUN
aiua-8854	142	15	and	and	CCONJ
aiua-8854	142	16	completion	completion	NOUN
aiua-8854	142	17	of	of	ADP
aiua-8854	142	18	treatment	treatment	NOUN
aiua-8854	142	19	in	in	ADP
aiua-8854	142	20	patients	patient	NOUN
aiua-8854	142	21	with	with	ADP
aiua-8854	142	22	metastatic	metastatic	ADJ
aiua-8854	142	23	castrationresistant	castrationresistant	NOUN
aiua-8854	142	24	prostate	prostate	NOUN
aiua-8854	142	25	cancer	cancer	NOUN
aiua-8854	142	26	treated	treat	VERB
aiua-8854	142	27	with	with	ADP
aiua-8854	142	28	radium-223	radium-223	NOUN
aiua-8854	142	29	in	in	ADP
aiua-8854	142	30	an	an	DET
aiua-8854	142	31	international	international	ADJ
aiua-8854	142	32	early	early	ADJ
aiua-8854	142	33	access	access	NOUN
aiua-8854	142	34	program	program	NOUN
aiua-8854	142	35	.	.	PUNCT
aiua-8854	143	1	clin	clin	PROPN
aiua-8854	143	2	genitourin	genitourin	PROPN
aiua-8854	143	3	cancer	cancer	NOUN
aiua-8854	143	4	.	.	PUNCT
aiua-8854	144	1	2019	2019	NUM
aiua-8854	144	2	;	;	PUNCT
aiua-8854	144	3	17:348355.e5	17:348355.e5	NUM
aiua-8854	144	4	21	21	NUM
aiua-8854	144	5	.	.	PUNCT
aiua-8854	145	1	parker	parker	PROPN
aiua-8854	145	2	c	c	PROPN
aiua-8854	145	3	,	,	PUNCT
aiua-8854	145	4	nilsson	nilsson	PROPN
aiua-8854	145	5	s	s	PROPN
aiua-8854	145	6	,	,	PUNCT
aiua-8854	145	7	heinrich	heinrich	PROPN
aiua-8854	145	8	d	d	PROPN
aiua-8854	145	9	,	,	PUNCT
aiua-8854	145	10	et	et	PROPN
aiua-8854	145	11	al	al	PROPN
aiua-8854	145	12	.	.	PROPN
aiua-8854	146	1	alpha	alpha	PROPN
aiua-8854	146	2	emitter	emitter	NOUN
aiua-8854	146	3	radium223	radium223	PROPN
aiua-8854	146	4	and	and	CCONJ
aiua-8854	146	5	survival	survival	NOUN
aiua-8854	146	6	in	in	ADP
aiua-8854	146	7	metastatic	metastatic	ADJ
aiua-8854	146	8	prostate	prostate	NOUN
aiua-8854	146	9	cancer	cancer	NOUN
aiua-8854	146	10	.	.	PUNCT
aiua-8854	147	1	n	n	PROPN
aiua-8854	147	2	engl	engl	PROPN
aiua-8854	147	3	j	j	PROPN
aiua-8854	147	4	med	med	PROPN
aiua-8854	147	5	.	.	PUNCT
aiua-8854	148	1	2013	2013	NUM
aiua-8854	148	2	;	;	PUNCT
aiua-8854	148	3	369:213	369:213	NUM
aiua-8854	148	4	-	-	SYM
aiua-8854	148	5	23	23	NUM
aiua-8854	148	6	.	.	PUNCT
aiua-8854	149	1	22	22	NUM
aiua-8854	149	2	.	.	PUNCT
aiua-8854	150	1	sartor	sartor	PROPN
aiua-8854	150	2	o	o	PROPN
aiua-8854	150	3	,	,	PUNCT
aiua-8854	150	4	coleman	coleman	PROPN
aiua-8854	150	5	r	r	PROPN
aiua-8854	150	6	,	,	PUNCT
aiua-8854	150	7	nilsson	nilsson	PROPN
aiua-8854	150	8	s	s	PROPN
aiua-8854	150	9	,	,	PUNCT
aiua-8854	150	10	et	et	PROPN
aiua-8854	150	11	al	al	PROPN
aiua-8854	150	12	.	.	PROPN
aiua-8854	150	13	effect	effect	NOUN
aiua-8854	150	14	of	of	ADP
aiua-8854	150	15	radium-223	radium-223	NOUN
aiua-8854	150	16	dichloride	dichloride	NOUN
aiua-8854	150	17	on	on	ADP
aiua-8854	150	18	symptomatic	symptomatic	ADJ
aiua-8854	150	19	skeletal	skeletal	ADJ
aiua-8854	150	20	events	event	NOUN
aiua-8854	150	21	in	in	ADP
aiua-8854	150	22	patients	patient	NOUN
aiua-8854	150	23	with	with	ADP
aiua-8854	150	24	castration	castration	NOUN
aiua-8854	150	25	-	-	PUNCT
aiua-8854	150	26	resistant	resistant	ADJ
aiua-8854	150	27	prostate	prostate	NOUN
aiua-8854	150	28	cancer	cancer	NOUN
aiua-8854	150	29	and	and	CCONJ
aiua-8854	150	30	bone	bone	NOUN
aiua-8854	150	31	metastases	metastasis	NOUN
aiua-8854	150	32	:	:	PUNCT
aiua-8854	150	33	results	result	NOUN
aiua-8854	150	34	from	from	ADP
aiua-8854	150	35	a	a	DET
aiua-8854	150	36	phase	phase	NOUN
aiua-8854	150	37	3	3	NUM
aiua-8854	150	38	,	,	PUNCT
aiua-8854	150	39	double	double	ADJ
aiua-8854	150	40	-	-	PUNCT
aiua-8854	150	41	blind	blind	ADJ
aiua-8854	150	42	,	,	PUNCT
aiua-8854	150	43	randomised	randomise	VERB
aiua-8854	150	44	trial	trial	NOUN
aiua-8854	150	45	.	.	PUNCT
aiua-8854	151	1	the	the	DET
aiua-8854	151	2	lancet	lancet	PROPN
aiua-8854	151	3	.	.	PUNCT
aiua-8854	152	1	oncology	oncology	NOUN
aiua-8854	152	2	.	.	PUNCT
aiua-8854	153	1	2014	2014	NUM
aiua-8854	153	2	;	;	PUNCT
aiua-8854	153	3	15:738	15:738	NUM
aiua-8854	153	4	-	-	SYM
aiua-8854	153	5	46	46	NUM
aiua-8854	153	6	.	.	PUNCT
aiua-8854	154	1	23	23	NUM
aiua-8854	154	2	.	.	PUNCT
aiua-8854	155	1	nilsson	nilsson	PROPN
aiua-8854	155	2	s	s	PROPN
aiua-8854	155	3	,	,	PUNCT
aiua-8854	155	4	cislo	cislo	PROPN
aiua-8854	155	5	p	p	PROPN
aiua-8854	155	6	,	,	PUNCT
aiua-8854	155	7	sartor	sartor	PROPN
aiua-8854	155	8	o	o	PROPN
aiua-8854	155	9	,	,	PUNCT
aiua-8854	155	10	et	et	PROPN
aiua-8854	155	11	al	al	PROPN
aiua-8854	155	12	.	.	PUNCT
aiua-8854	155	13	patient	patient	NOUN
aiua-8854	155	14	-	-	PUNCT
aiua-8854	155	15	reported	report	VERB
aiua-8854	155	16	quality	quality	NOUN
aiua-8854	155	17	-	-	PUNCT
aiua-8854	155	18	oflife	oflife	NOUN
aiua-8854	155	19	analysis	analysis	NOUN
aiua-8854	155	20	of	of	ADP
aiua-8854	155	21	radium-223	radium-223	NOUN
aiua-8854	155	22	dichloride	dichloride	NOUN
aiua-8854	155	23	from	from	ADP
aiua-8854	155	24	the	the	DET
aiua-8854	155	25	phase	phase	NOUN
aiua-8854	155	26	iii	iii	NUM
aiua-8854	155	27	alsympca	alsympca	NOUN
aiua-8854	155	28	study	study	NOUN
aiua-8854	155	29	.	.	PUNCT
aiua-8854	156	1	ann	ann	PROPN
aiua-8854	156	2	oncol	oncol	PROPN
aiua-8854	156	3	.	.	PUNCT
aiua-8854	157	1	2016	2016	NUM
aiua-8854	157	2	;	;	PUNCT
aiua-8854	157	3	27:868	27:868	NUM
aiua-8854	157	4	-	-	SYM
aiua-8854	157	5	74	74	NUM
aiua-8854	157	6	.	.	PUNCT
aiua-8854	158	1	24	24	NUM
aiua-8854	158	2	.	.	PUNCT
aiua-8854	159	1	sartor	sartor	PROPN
aiua-8854	159	2	ao	ao	PROPN
aiua-8854	159	3	,	,	PUNCT
aiua-8854	159	4	heinrich	heinrich	PROPN
aiua-8854	159	5	d	d	PROPN
aiua-8854	159	6	,	,	PUNCT
aiua-8854	159	7	mariados	mariado	NOUN
aiua-8854	159	8	n	n	CCONJ
aiua-8854	159	9	,	,	PUNCT
aiua-8854	159	10	et	et	PROPN
aiua-8854	159	11	al	al	PROPN
aiua-8854	159	12	.	.	PROPN
aiua-8854	159	13	radium-223	radium-223	NOUN
aiua-8854	159	14	(	(	PUNCT
aiua-8854	159	15	ra223	ra223	NOUN
aiua-8854	159	16	)	)	PUNCT
aiua-8854	159	17	re	re	NOUN
aiua-8854	159	18	-	-	NOUN
aiua-8854	159	19	treatment	treatment	NOUN
aiua-8854	159	20	(	(	PUNCT
aiua-8854	159	21	re	re	NOUN
aiua-8854	159	22	-	-	VERB
aiua-8854	159	23	tx	tx	ADJ
aiua-8854	159	24	):	):	PUNCT
aiua-8854	159	25	first	first	ADJ
aiua-8854	159	26	experience	experience	NOUN
aiua-8854	159	27	from	from	ADP
aiua-8854	159	28	an	an	DET
aiua-8854	159	29	international	international	ADJ
aiua-8854	159	30	,	,	PUNCT
aiua-8854	159	31	multicenter	multicenter	NOUN
aiua-8854	159	32	,	,	PUNCT
aiua-8854	159	33	prospective	prospective	ADJ
aiua-8854	159	34	study	study	NOUN
aiua-8854	159	35	in	in	ADP
aiua-8854	159	36	patients	patient	NOUN
aiua-8854	159	37	(	(	PUNCT
aiua-8854	159	38	pts	pt	NOUN
aiua-8854	159	39	)	)	PUNCT
aiua-8854	159	40	with	with	ADP
aiua-8854	159	41	castration	castration	NOUN
aiua-8854	159	42	-	-	PUNCT
aiua-8854	159	43	resistant	resistant	ADJ
aiua-8854	159	44	prostate	prostate	NOUN
aiua-8854	159	45	cancer	cancer	NOUN
aiua-8854	159	46	and	and	CCONJ
aiua-8854	159	47	bone	bone	NOUN
aiua-8854	159	48	metastases	metastasis	NOUN
aiua-8854	159	49	(	(	PUNCT
aiua-8854	159	50	mcrpc	mcrpc	NOUN
aiua-8854	159	51	)	)	PUNCT
aiua-8854	159	52	.	.	PUNCT
aiua-8854	160	1	journal	journal	NOUN
aiua-8854	160	2	of	of	ADP
aiua-8854	160	3	clinical	clinical	ADJ
aiua-8854	160	4	oncology	oncology	NOUN
aiua-8854	160	5	.	.	PUNCT
aiua-8854	161	1	2016	2016	NUM
aiua-8854	161	2	;	;	PUNCT
aiua-8854	161	3	34(suppl	34(suppl	NUM
aiua-8854	161	4	2):197	2):197	NUM
aiua-8854	161	5	.	.	PUNCT
aiua-8854	162	1	25	25	NUM
aiua-8854	162	2	.	.	PUNCT
aiua-8854	163	1	sartor	sartor	PROPN
aiua-8854	163	2	o	o	PROPN
aiua-8854	163	3	,	,	PUNCT
aiua-8854	163	4	heinrich	heinrich	PROPN
aiua-8854	163	5	d	d	PROPN
aiua-8854	163	6	,	,	PUNCT
aiua-8854	163	7	mariados	mariado	NOUN
aiua-8854	163	8	n	n	CCONJ
aiua-8854	163	9	,	,	PUNCT
aiua-8854	163	10	et	et	PROPN
aiua-8854	163	11	al	al	PROPN
aiua-8854	163	12	.	.	PROPN
aiua-8854	163	13	re	re	PROPN
aiua-8854	163	14	-	-	NOUN
aiua-8854	163	15	treatment	treatment	NOUN
aiua-8854	163	16	with	with	ADP
aiua-8854	163	17	radium-223	radium-223	NOUN
aiua-8854	163	18	:	:	PUNCT
aiua-8854	163	19	2	2	NUM
aiua-8854	163	20	-	-	PUNCT
aiua-8854	163	21	year	year	NOUN
aiua-8854	163	22	follow	follow	NOUN
aiua-8854	163	23	-	-	PUNCT
aiua-8854	163	24	up	up	NOUN
aiua-8854	163	25	from	from	ADP
aiua-8854	163	26	an	an	DET
aiua-8854	163	27	international	international	ADJ
aiua-8854	163	28	,	,	PUNCT
aiua-8854	163	29	open	open	ADJ
aiua-8854	163	30	-	-	PUNCT
aiua-8854	163	31	label	label	NOUN
aiua-8854	163	32	,	,	PUNCT
aiua-8854	163	33	phase	phase	NOUN
aiua-8854	163	34	1/2	1/2	NUM
aiua-8854	163	35	study	study	NOUN
aiua-8854	163	36	in	in	ADP
aiua-8854	163	37	patients	patient	NOUN
aiua-8854	163	38	with	with	ADP
aiua-8854	163	39	castration	castration	NOUN
aiua-8854	163	40	-	-	PUNCT
aiua-8854	163	41	resistant	resistant	ADJ
aiua-8854	163	42	prostate	prostate	NOUN
aiua-8854	163	43	cancer	cancer	NOUN
aiua-8854	163	44	and	and	CCONJ
aiua-8854	163	45	bone	bone	NOUN
aiua-8854	163	46	metastases	metastasis	NOUN
aiua-8854	163	47	.	.	PUNCT
aiua-8854	164	1	prostate	prostate	NOUN
aiua-8854	164	2	.	.	PUNCT
aiua-8854	165	1	2019	2019	NUM
aiua-8854	165	2	;	;	PUNCT
aiua-8854	166	1	79:1683	79:1683	NOUN
aiua-8854	166	2	-	-	SYM
aiua-8854	166	3	91	91	NUM
aiua-8854	166	4	.	.	PUNCT
aiua-8854	166	5	26	26	NUM
aiua-8854	166	6	.	.	PUNCT
aiua-8854	167	1	parker	parker	PROPN
aiua-8854	167	2	cc	cc	PROPN
aiua-8854	167	3	,	,	PUNCT
aiua-8854	167	4	pascoe	pascoe	PROPN
aiua-8854	167	5	s	s	PART
aiua-8854	167	6	,	,	PUNCT
aiua-8854	167	7	chodacki	chodacki	NOUN
aiua-8854	167	8	a	a	NOUN
aiua-8854	167	9	,	,	PUNCT
aiua-8854	167	10	et	et	PROPN
aiua-8854	167	11	al	al	PROPN
aiua-8854	167	12	.	.	PUNCT
aiua-8854	168	1	a	a	DET
aiua-8854	168	2	randomized	randomized	ADJ
aiua-8854	168	3	,	,	PUNCT
aiua-8854	168	4	doubleblind	doubleblind	NOUN
aiua-8854	168	5	,	,	PUNCT
aiua-8854	168	6	dose	dose	NOUN
aiua-8854	168	7	-	-	PUNCT
aiua-8854	168	8	finding	finding	NOUN
aiua-8854	168	9	,	,	PUNCT
aiua-8854	168	10	multicenter	multicenter	NOUN
aiua-8854	168	11	,	,	PUNCT
aiua-8854	168	12	phase	phase	NOUN
aiua-8854	168	13	2	2	NUM
aiua-8854	168	14	study	study	NOUN
aiua-8854	168	15	of	of	ADP
aiua-8854	168	16	radium	radium	NOUN
aiua-8854	168	17	chloride	chloride	NOUN
aiua-8854	168	18	(	(	PUNCT
aiua-8854	168	19	ra	ra	NOUN
aiua-8854	168	20	223	223	NUM
aiua-8854	168	21	)	)	PUNCT
aiua-8854	168	22	in	in	ADP
aiua-8854	168	23	patients	patient	NOUN
aiua-8854	168	24	with	with	ADP
aiua-8854	168	25	bone	bone	NOUN
aiua-8854	168	26	metastases	metastasis	NOUN
aiua-8854	168	27	and	and	CCONJ
aiua-8854	168	28	castration	castration	NOUN
aiua-8854	168	29	-	-	PUNCT
aiua-8854	168	30	resistant	resistant	ADJ
aiua-8854	168	31	prostate	prostate	NOUN
aiua-8854	168	32	cancer	cancer	NOUN
aiua-8854	168	33	.	.	PUNCT
aiua-8854	169	1	eur	eur	PROPN
aiua-8854	169	2	urol	urol	PROPN
aiua-8854	169	3	.	.	PUNCT
aiua-8854	170	1	2013	2013	NUM
aiua-8854	170	2	;	;	PUNCT
aiua-8854	170	3	63:189	63:189	NUM
aiua-8854	170	4	-	-	SYM
aiua-8854	170	5	97	97	NUM
aiua-8854	170	6	.	.	PUNCT
aiua-8854	171	1	27	27	NUM
aiua-8854	171	2	.	.	PUNCT
aiua-8854	171	3	nct02023697	nct02023697	PROPN
aiua-8854	171	4	.	.	PUNCT
aiua-8854	172	1	radium-223	radium-223	NOUN
aiua-8854	172	2	dichloride	dichloride	NOUN
aiua-8854	172	3	50	50	NUM
aiua-8854	172	4	kbq	kbq	PROPN
aiua-8854	172	5	/	/	SYM
aiua-8854	172	6	kg	kg	PROPN
aiua-8854	172	7	(	(	PUNCT
aiua-8854	172	8	55	55	NUM
aiua-8854	172	9	kbq	kbq	PROPN
aiua-8854	172	10	/	/	SYM
aiua-8854	172	11	kg	kg	PROPN
aiua-8854	172	12	after	after	ADP
aiua-8854	172	13	implementation	implementation	NOUN
aiua-8854	172	14	of	of	ADP
aiua-8854	172	15	nist	nist	NOUN
aiua-8854	172	16	update	update	NOUN
aiua-8854	172	17	)	)	PUNCT
aiua-8854	172	18	versus	versus	ADP
aiua-8854	172	19	80	80	NUM
aiua-8854	172	20	kbq	kbq	PROPN
aiua-8854	172	21	/	/	SYM
aiua-8854	172	22	kg	kg	PROPN
aiua-8854	172	23	(	(	PUNCT
aiua-8854	172	24	88	88	NUM
aiua-8854	172	25	kbq	kbq	NOUN
aiua-8854	172	26	/	/	SYM
aiua-8854	172	27	kg	kg	PROPN
aiua-8854	172	28	after	after	ADP
aiua-8854	172	29	implementation	implementation	NOUN
aiua-8854	172	30	of	of	ADP
aiua-8854	172	31	nist	nist	NOUN
aiua-8854	172	32	update	update	NOUN
aiua-8854	172	33	)	)	PUNCT
aiua-8854	172	34	,	,	PUNCT
aiua-8854	172	35	and	and	CCONJ
aiua-8854	172	36	versus	versus	ADP
aiua-8854	172	37	50	50	NUM
aiua-8854	172	38	kbq	kbq	NOUN
aiua-8854	172	39	/	/	SYM
aiua-8854	172	40	kg	kg	PROPN
aiua-8854	172	41	(	(	PUNCT
aiua-8854	172	42	55	55	NUM
aiua-8854	172	43	kbq	kbq	PROPN
aiua-8854	172	44	/	/	SYM
aiua-8854	172	45	kg	kg	PROPN
aiua-8854	172	46	after	after	ADP
aiua-8854	172	47	implementation	implementation	NOUN
aiua-8854	172	48	of	of	ADP
aiua-8854	172	49	nist	nist	NOUN
aiua-8854	172	50	update	update	NOUN
aiua-8854	172	51	)	)	PUNCT
aiua-8854	172	52	in	in	ADP
aiua-8854	172	53	an	an	DET
aiua-8854	172	54	extended	extended	ADJ
aiua-8854	172	55	dosing	dosing	NOUN
aiua-8854	172	56	schedule	schedule	NOUN
aiua-8854	172	57	in	in	ADP
aiua-8854	172	58	subjects	subject	NOUN
aiua-8854	172	59	with	with	ADP
aiua-8854	172	60	castration	castration	NOUN
aiua-8854	172	61	-	-	PUNCT
aiua-8854	172	62	resistant	resistant	ADJ
aiua-8854	172	63	prostate	prostate	NOUN
aiua-8854	172	64	cancer	cancer	NOUN
aiua-8854	172	65	metastatic	metastatic	NOUN
aiua-8854	172	66	to	to	ADP
aiua-8854	172	67	the	the	DET
aiua-8854	172	68	bone	bone	NOUN
aiua-8854	172	69	.	.	PUNCT
aiua-8854	173	1	https://clinicaltrials.gov/ct2/show/	https://clinicaltrials.gov/ct2/show/	PROPN
aiua-8854	173	2	results	result	NOUN
aiua-8854	173	3	/	/	SYM
aiua-8854	173	4	nct0202369	nct0202369	NOUN
aiua-8854	173	5	.	.	PUNCT
aiua-8854	174	1	28	28	NUM
aiua-8854	174	2	.	.	PUNCT
aiua-8854	175	1	nilsson	nilsson	PROPN
aiua-8854	175	2	s	s	PROPN
aiua-8854	175	3	,	,	PUNCT
aiua-8854	175	4	larsen	larsen	PROPN
aiua-8854	175	5	rh	rh	PROPN
aiua-8854	175	6	,	,	PUNCT
aiua-8854	175	7	fossa	fossa	VERB
aiua-8854	175	8	sd	sd	NOUN
aiua-8854	175	9	,	,	PUNCT
aiua-8854	175	10	et	et	PROPN
aiua-8854	175	11	al	al	PROPN
aiua-8854	175	12	.	.	PUNCT
aiua-8854	176	1	first	first	ADJ
aiua-8854	176	2	clinical	clinical	ADJ
aiua-8854	176	3	experience	experience	NOUN
aiua-8854	176	4	with	with	ADP
aiua-8854	176	5	alpha	alpha	NOUN
aiua-8854	176	6	-	-	PUNCT
aiua-8854	176	7	emitting	emit	VERB
aiua-8854	176	8	radium-223	radium-223	NOUN
aiua-8854	176	9	in	in	ADP
aiua-8854	176	10	the	the	DET
aiua-8854	176	11	treatment	treatment	NOUN
aiua-8854	176	12	of	of	ADP
aiua-8854	176	13	skeletal	skeletal	ADJ
aiua-8854	176	14	metastases	metastasis	NOUN
aiua-8854	176	15	.	.	PUNCT
aiua-8854	177	1	clin	clin	PROPN
aiua-8854	177	2	cancer	cancer	NOUN
aiua-8854	177	3	res	re	NOUN
aiua-8854	177	4	.	.	PUNCT
aiua-8854	177	5	2005	2005	NUM
aiua-8854	177	6	;	;	PUNCT
aiua-8854	177	7	11:4451	11:4451	NUM
aiua-8854	177	8	-	-	SYM
aiua-8854	177	9	9	9	NUM
aiua-8854	177	10	.	.	NOUN
aiua-8854	177	11	29	29	NUM
aiua-8854	177	12	.	.	PUNCT
aiua-8854	177	13	prelaj	prelaj	VERB
aiua-8854	177	14	a	a	PRON
aiua-8854	177	15	,	,	PUNCT
aiua-8854	177	16	rebuzzi	rebuzzi	NOUN
aiua-8854	177	17	se	se	PROPN
aiua-8854	177	18	,	,	PUNCT
aiua-8854	177	19	buzzacchino	buzzacchino	PROPN
aiua-8854	177	20	f	f	PROPN
aiua-8854	177	21	,	,	PUNCT
aiua-8854	177	22	et	et	PROPN
aiua-8854	177	23	al	al	PROPN
aiua-8854	177	24	.	.	PROPN
aiua-8854	177	25	radium-223	radium-223	NOUN
aiua-8854	177	26	in	in	ADP
aiua-8854	177	27	patients	patient	NOUN
aiua-8854	177	28	with	with	ADP
aiua-8854	177	29	metastatic	metastatic	ADJ
aiua-8854	177	30	castration	castration	NOUN
aiua-8854	177	31	-	-	PUNCT
aiua-8854	177	32	resistant	resistant	ADJ
aiua-8854	177	33	prostate	prostate	NOUN
aiua-8854	177	34	cancer	cancer	NOUN
aiua-8854	177	35	:	:	PUNCT
aiua-8854	177	36	efficacy	efficacy	NOUN
aiua-8854	177	37	and	and	CCONJ
aiua-8854	177	38	safety	safety	NOUN
aiua-8854	177	39	in	in	ADP
aiua-8854	177	40	clinical	clinical	ADJ
aiua-8854	177	41	practice	practice	NOUN
aiua-8854	177	42	.	.	PUNCT
aiua-8854	178	1	oncol	oncol	ADJ
aiua-8854	178	2	lett	lett	PROPN
aiua-8854	178	3	.	.	PROPN
aiua-8854	179	1	2019	2019	NUM
aiua-8854	179	2	;	;	PUNCT
aiua-8854	179	3	17:1467	17:1467	NUM
aiua-8854	179	4	-	-	SYM
aiua-8854	179	5	76	76	NUM
aiua-8854	179	6	.	.	PUNCT
aiua-8854	180	1	30	30	NUM
aiua-8854	180	2	.	.	X
aiua-8854	180	3	de	de	PROPN
aiua-8854	180	4	vincentis	vincentis	PROPN
aiua-8854	180	5	g	g	PROPN
aiua-8854	180	6	,	,	PUNCT
aiua-8854	180	7	follacchio	follacchio	PROPN
aiua-8854	180	8	ga	ga	PROPN
aiua-8854	180	9	,	,	PUNCT
aiua-8854	180	10	frantellizzi	frantellizzi	NOUN
aiua-8854	180	11	v	v	NOUN
aiua-8854	180	12	,	,	PUNCT
aiua-8854	180	13	et	et	PROPN
aiua-8854	180	14	al	al	PROPN
aiua-8854	180	15	.	.	PUNCT
aiua-8854	181	1	223radichloride	223radichloride	PROPN
aiua-8854	181	2	therapy	therapy	NOUN
aiua-8854	181	3	in	in	ADP
aiua-8854	181	4	an	an	DET
aiua-8854	181	5	elderly	elderly	ADJ
aiua-8854	181	6	bone	bone	NOUN
aiua-8854	181	7	metastatic	metastatic	ADJ
aiua-8854	181	8	castration	castration	NOUN
aiua-8854	181	9	-	-	PUNCT
aiua-8854	181	10	resistant	resistant	ADJ
aiua-8854	181	11	prostate	prostate	NOUN
aiua-8854	181	12	cancer	cancer	NOUN
aiua-8854	181	13	patient	patient	NOUN
aiua-8854	181	14	:	:	PUNCT
aiua-8854	181	15	a	a	DET
aiua-8854	181	16	case	case	NOUN
aiua-8854	181	17	report	report	NOUN
aiua-8854	181	18	presentation	presentation	NOUN
aiua-8854	181	19	and	and	CCONJ
aiua-8854	181	20	comparison	comparison	NOUN
aiua-8854	181	21	with	with	ADP
aiua-8854	181	22	existing	exist	VERB
aiua-8854	181	23	literature	literature	NOUN
aiua-8854	181	24	.	.	PUNCT
aiua-8854	182	1	aging	age	VERB
aiua-8854	182	2	clin	clin	PROPN
aiua-8854	182	3	exp	exp	NOUN
aiua-8854	182	4	res	re	NOUN
aiua-8854	182	5	.	.	PUNCT
aiua-8854	182	6	2018	2018	NUM
aiua-8854	182	7	;	;	PUNCT
aiua-8854	182	8	30:677	30:677	NUM
aiua-8854	182	9	-	-	SYM
aiua-8854	182	10	680	680	NUM
aiua-8854	182	11	.	.	PUNCT
aiua-8854	183	1	31	31	NUM
aiua-8854	183	2	.	.	PUNCT
aiua-8854	184	1	vogelzang	vogelzang	PROPN
aiua-8854	184	2	nj	nj	PROPN
aiua-8854	184	3	,	,	PUNCT
aiua-8854	184	4	coleman	coleman	PROPN
aiua-8854	184	5	re	re	PROPN
aiua-8854	184	6	,	,	PUNCT
aiua-8854	184	7	michalski	michalski	PROPN
aiua-8854	184	8	jm	jm	PROPN
aiua-8854	184	9	,	,	PUNCT
aiua-8854	184	10	et	et	PROPN
aiua-8854	184	11	al	al	PROPN
aiua-8854	184	12	.	.	PROPN
aiua-8854	184	13	hematologic	hematologic	NOUN
aiua-8854	184	14	safety	safety	NOUN
aiua-8854	184	15	of	of	ADP
aiua-8854	184	16	radium-223	radium-223	NOUN
aiua-8854	184	17	dichloride	dichloride	NOUN
aiua-8854	184	18	:	:	PUNCT
aiua-8854	184	19	baseline	baseline	PROPN
aiua-8854	184	20	prognostic	prognostic	ADJ
aiua-8854	184	21	factors	factor	NOUN
aiua-8854	184	22	associated	associate	VERB
aiua-8854	184	23	with	with	ADP
aiua-8854	184	24	myelosuppression	myelosuppression	NOUN
aiua-8854	184	25	in	in	ADP
aiua-8854	184	26	the	the	DET
aiua-8854	184	27	alsympca	alsympca	NOUN
aiua-8854	184	28	trial	trial	NOUN
aiua-8854	184	29	.	.	PUNCT
aiua-8854	185	1	clin	clin	PROPN
aiua-8854	185	2	genitourin	genitourin	PROPN
aiua-8854	185	3	cancer	cancer	NOUN
aiua-8854	185	4	.	.	PUNCT
aiua-8854	186	1	2017	2017	NUM
aiua-8854	186	2	;	;	PUNCT
aiua-8854	186	3	15:42	15:42	NUM
aiua-8854	186	4	-	-	SYM
aiua-8854	186	5	52.e8	52.e8	NUM
aiua-8854	186	6	.	.	PUNCT
aiua-8854	186	7	correspondence	correspondence	NOUN
aiua-8854	186	8	viviana	viviana	PROPN
aiua-8854	186	9	frantellizzi	frantellizzi	PROPN
aiua-8854	186	10	,	,	PUNCT
aiua-8854	186	11	md	md	PROPN
aiua-8854	186	12	,	,	PUNCT
aiua-8854	186	13	phd	phd	PROPN
aiua-8854	186	14	viviana.frantellizzi@uniroma1.it	viviana.frantellizzi@uniroma1.it	PROPN
aiua-8854	186	15	department	department	NOUN
aiua-8854	186	16	of	of	ADP
aiua-8854	186	17	molecular	molecular	ADJ
aiua-8854	186	18	medicine	medicine	NOUN
aiua-8854	186	19	,	,	PUNCT
aiua-8854	186	20	sapienza	sapienza	PROPN
aiua-8854	186	21	university	university	PROPN
aiua-8854	186	22	of	of	ADP
aiua-8854	186	23	rome	rome	PROPN
aiua-8854	186	24	viale	viale	PROPN
aiua-8854	186	25	regina	regina	PROPN
aiua-8854	186	26	elena	elena	PROPN
aiua-8854	186	27	324	324	NUM
aiua-8854	186	28	,	,	PUNCT
aiua-8854	186	29	00161	00161	NUM
aiua-8854	186	30	rome	rome	PROPN
aiua-8854	186	31	(	(	PUNCT
aiua-8854	186	32	italy	italy	PROPN
aiua-8854	186	33	)	)	PUNCT
aiua-8854	186	34	julia	julia	PROPN
aiua-8854	186	35	lazri	lazri	PROPN
aiua-8854	186	36	,	,	PUNCT
aiua-8854	186	37	md	md	PROPN
aiua-8854	186	38	julia.lazri@uniroma1.it	julia.lazri@uniroma1.it	PROPN
aiua-8854	186	39	giuseppe	giuseppe	PROPN
aiua-8854	186	40	de	de	PROPN
aiua-8854	186	41	vincentis	vincentis	PROPN
aiua-8854	186	42	,	,	PUNCT
aiua-8854	186	43	md	md	PROPN
aiua-8854	186	44	,	,	PUNCT
aiua-8854	186	45	phd	phd	NOUN
aiua-8854	186	46	giuseppe.devincentis@uniroma1.it	giuseppe.devincentis@uniroma1.it	PROPN
aiua-8854	186	47	department	department	PROPN
aiua-8854	186	48	of	of	ADP
aiua-8854	186	49	radiological	radiological	ADJ
aiua-8854	186	50	sciences	science	NOUN
aiua-8854	186	51	,	,	PUNCT
aiua-8854	186	52	oncology	oncology	NOUN
aiua-8854	186	53	and	and	CCONJ
aiua-8854	186	54	anatomical	anatomical	ADJ
aiua-8854	186	55	pathology	pathology	NOUN
aiua-8854	186	56	,	,	PUNCT
aiua-8854	186	57	sapienza	sapienza	PROPN
aiua-8854	186	58	university	university	PROPN
aiua-8854	186	59	of	of	ADP
aiua-8854	186	60	rome	rome	PROPN
aiua-8854	186	61	,	,	PUNCT
aiua-8854	186	62	viale	viale	PROPN
aiua-8854	186	63	regina	regina	PROPN
aiua-8854	186	64	elena	elena	PROPN
aiua-8854	186	65	324	324	NUM
aiua-8854	186	66	,	,	PUNCT
aiua-8854	186	67	rome	rome	PROPN
aiua-8854	186	68	(	(	PUNCT
aiua-8854	186	69	italy	italy	PROPN
aiua-8854	186	70	)	)	PUNCT
aiua-8854	186	71	mariano	mariano	PROPN
aiua-8854	186	72	pontico	pontico	PROPN
aiua-8854	186	73	,	,	PUNCT
aiua-8854	186	74	md	md	PROPN
aiua-8854	186	75	mariano.pontico@uniroma1.it	mariano.pontico@uniroma1.it	PROPN
aiua-8854	186	76	ph.d	ph.d	PROPN
aiua-8854	186	77	program	program	NOUN
aiua-8854	186	78	in	in	ADP
aiua-8854	186	79	morphogenesis	morphogenesis	NOUN
aiua-8854	186	80	&	&	CCONJ
aiua-8854	186	81	tissue	tissue	NOUN
aiua-8854	186	82	engineering	engineering	NOUN
aiua-8854	186	83	,	,	PUNCT
aiua-8854	186	84	“	"	PUNCT
aiua-8854	186	85	sapienza	sapienza	ADJ
aiua-8854	186	86	”	"	PUNCT
aiua-8854	186	87	university	university	PROPN
aiua-8854	186	88	of	of	ADP
aiua-8854	186	89	rome	rome	PROPN
aiua-8854	186	90	,	,	PUNCT
aiua-8854	186	91	viale	viale	PROPN
aiua-8854	186	92	regina	regina	PROPN
aiua-8854	186	93	elena	elena	PROPN
aiua-8854	186	94	324	324	NUM
aiua-8854	186	95	,	,	PUNCT
aiua-8854	186	96	rome	rome	PROPN
aiua-8854	186	97	(	(	PUNCT
aiua-8854	186	98	italy	italy	PROPN
aiua-8854	186	99	)	)	PUNCT
aiua-8854	186	100	arianna	arianna	PROPN
aiua-8854	186	101	pani	pani	PROPN
aiua-8854	186	102	,	,	PUNCT
aiua-8854	186	103	md	md	PROPN
aiua-8854	186	104	arianna.pani@gmail.com	arianna.pani@gmail.com	PROPN
aiua-8854	186	105	clinical	clinical	ADJ
aiua-8854	186	106	pharmacology	pharmacology	NOUN
aiua-8854	186	107	and	and	CCONJ
aiua-8854	186	108	toxicology	toxicology	NOUN
aiua-8854	186	109	,	,	PUNCT
aiua-8854	186	110	university	university	PROPN
aiua-8854	186	111	of	of	ADP
aiua-8854	186	112	milan	milan	PROPN
aiua-8854	186	113	,	,	PUNCT
aiua-8854	186	114	l.go	l.go	PROPN
aiua-8854	186	115	de	de	PROPN
aiua-8854	186	116	benedetti	benedetti	PROPN
aiua-8854	186	117	1	1	NUM
aiua-8854	186	118	,	,	PUNCT
aiua-8854	186	119	milan	milan	PROPN
aiua-8854	186	120	(	(	PUNCT
aiua-8854	186	121	italy	italy	PROPN
aiua-8854	186	122	)	)	PUNCT
aiua-8854	186	123	08fantellizzi_stesura	08fantellizzi_stesura	PROPN
aiua-8854	186	124	seveso	seveso	VERB
aiua-8854	186	125	24/09/20	24/09/20	PROPN
aiua-8854	186	126	14:20	14:20	NUM
aiua-8854	186	127	pagina	pagina	NOUN
aiua-8854	186	128	199	199	NUM