id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
arestyrurj-138	Kaur, Amanpreet	The Role of Eicosanoids in Regulating the Ubiquitin Proteasome System and Proteostasis	2020	19	.pdf	application/pdf	6342	354	62	This is supported by previous studies that found the effects of ω-3 PUFAs varied depending on the tissue in question, with reduced UPS activity in cachexia cancer cells and increased UPS activity in HPV-infected cancer cells.11 In the intestine, ω-3 PUFAs or their derived eicosanoids may promote UPS activity, or ω-6 PUFAs or their derived eicosanoids may inhibit it. Interestingly, wild-type worms also appear to differ in UPS activity in the hypodermis and the intestine, with the intestine experiencing earlier UPS activity than the hypodermis.7 In total, these results suggest that PUFAs or their eicosanoid derivatives regulate UPS activity in a tissue-specific fashion.	cache/arestyrurj-138.pdf	txt/arestyrurj-138.txt