id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
arestyrurj-171	Allada, Tamara; Ilnytska, Olga; Storch, Judith	The Role of Autophagy in Phosphatidylglycerol Facilitated Cholesterol Clearance from the Endolysosomal System of NPC-1 Deficient Cells	2021	7	.pdf	application/pdf	3769	231	59	This is because the limiting membrane of a lysosome is covered in a sugar coat called glycocalyx and it is believed that the luminal domains of the NPC-1 protein are required for cho- lesterol to be able to penetrate through the gly- cocalyx and exit the lysosome.[11,12] Increasing the LBPA levels in NPC-1 deficient cells have been found to result in a significant amount of cholesterol clear- ance because the LBPA can still interact with the NPC-2 protein.[6] Exogenous treatment of LBPA’s precursor phosphatidylglycerol, or PG, also results in cholesterol clearance because the PG can go through its biosynthetic pathway to make LBPA.[13] Our preliminary data shows that PG treat- ment of NPC-1 deficient cells facilitates autophago- some fusion with the lysosome and subsequent au- tophagic flux. Since NPC-1 deficient cells block au- tophagy and PG helps it resume, we are interested in seeing if autolysosome formation and autophagic flux are involved in cholesterol clearance from late endosomes when these cells are treated with PG.	cache/arestyrurj-171.pdf	txt/arestyrurj-171.txt