id	sid	tid	token	lemma	pos
arestyrurj-171	1	1	aresty	aresty	PROPN
arestyrurj-171	1	2	rutgers	rutgers	PROPN
arestyrurj-171	1	3	undergraduate	undergraduate	PROPN
arestyrurj-171	1	4	research	research	PROPN
arestyrurj-171	1	5	journal	journal	PROPN
arestyrurj-171	1	6	,	,	PUNCT
arestyrurj-171	1	7	volume	volume	NOUN
arestyrurj-171	1	8	i	i	PRON
arestyrurj-171	1	9	,	,	PUNCT
arestyrurj-171	1	10	issue	issue	VERB
arestyrurj-171	1	11	iii	iii	NOUN
arestyrurj-171	1	12	this	this	DET
arestyrurj-171	1	13	work	work	NOUN
arestyrurj-171	1	14	is	be	AUX
arestyrurj-171	1	15	licensed	license	VERB
arestyrurj-171	1	16	under	under	ADP
arestyrurj-171	1	17	a	a	DET
arestyrurj-171	1	18	creative	creative	ADJ
arestyrurj-171	1	19	commons	common	NOUN
arestyrurj-171	1	20	attribution	attribution	NOUN
arestyrurj-171	1	21	-	-	PUNCT
arestyrurj-171	1	22	noncommercial	noncommercial	ADJ
arestyrurj-171	1	23	-	-	PUNCT
arestyrurj-171	1	24	sharealike	sharealike	ADJ
arestyrurj-171	1	25	4.0	4.0	NUM
arestyrurj-171	1	26	international	international	ADJ
arestyrurj-171	1	27	license	license	NOUN
arestyrurj-171	1	28	.	.	PUNCT
arestyrurj-171	2	1	the	the	DET
arestyrurj-171	2	2	role	role	NOUN
arestyrurj-171	2	3	of	of	ADP
arestyrurj-171	2	4	autophagy	autophagy	NOUN
arestyrurj-171	2	5	in	in	ADP
arestyrurj-171	2	6	phosphatidyl	phosphatidyl	NOUN
arestyrurj-171	2	7	glycerol	glycerol	NOUN
arestyrurj-171	2	8	facilitated	facilitate	VERB
arestyrurj-171	2	9	cholesterol	cholesterol	NOUN
arestyrurj-171	2	10	clearance	clearance	NOUN
arestyrurj-171	2	11	from	from	ADP
arestyrurj-171	2	12	the	the	DET
arestyrurj-171	2	13	endolysosomal	endolysosomal	ADJ
arestyrurj-171	2	14	system	system	NOUN
arestyrurj-171	2	15	of	of	ADP
arestyrurj-171	2	16	npc-1	npc-1	NOUN
arestyrurj-171	2	17	deficient	deficient	ADJ
arestyrurj-171	2	18	cells	cell	NOUN
arestyrurj-171	2	19	tamara	tamara	PROPN
arestyrurj-171	2	20	allada	allada	PROPN
arestyrurj-171	2	21	,	,	PUNCT
arestyrurj-171	2	22	olga	olga	PROPN
arestyrurj-171	2	23	ilnytska	ilnytska	PROPN
arestyrurj-171	2	24	phd	phd	PROPN
arestyrurj-171	2	25	,	,	PUNCT
arestyrurj-171	2	26	judith	judith	PROPN
arestyrurj-171	2	27	storch	storch	PROPN
arestyrurj-171	2	28	(	(	PUNCT
arestyrurj-171	2	29	faculty	faculty	NOUN
arestyrurj-171	2	30	advisor	advisor	NOUN
arestyrurj-171	2	31	)	)	PUNCT
arestyrurj-171	2	32	✵	✵	PROPN
arestyrurj-171	2	33	abstract	abstract	PROPN
arestyrurj-171	2	34	niemann	niemann	PROPN
arestyrurj-171	2	35	pick	pick	PROPN
arestyrurj-171	2	36	type	type	NOUN
arestyrurj-171	2	37	c	c	PROPN
arestyrurj-171	2	38	(	(	PUNCT
arestyrurj-171	2	39	npc	npc	NOUN
arestyrurj-171	2	40	)	)	PUNCT
arestyrurj-171	2	41	disease	disease	NOUN
arestyrurj-171	2	42	is	be	AUX
arestyrurj-171	2	43	a	a	DET
arestyrurj-171	2	44	rare	rare	ADJ
arestyrurj-171	2	45	lysosomal	lysosomal	ADJ
arestyrurj-171	2	46	storage	storage	NOUN
arestyrurj-171	2	47	disorder	disorder	NOUN
arestyrurj-171	2	48	in	in	ADP
arestyrurj-171	2	49	which	which	PRON
arestyrurj-171	2	50	one	one	NUM
arestyrurj-171	2	51	of	of	ADP
arestyrurj-171	2	52	the	the	DET
arestyrurj-171	2	53	genes	gene	NOUN
arestyrurj-171	2	54	that	that	PRON
arestyrurj-171	2	55	codes	code	VERB
arestyrurj-171	2	56	for	for	ADP
arestyrurj-171	2	57	either	either	CCONJ
arestyrurj-171	2	58	the	the	DET
arestyrurj-171	2	59	npc-1	npc-1	NOUN
arestyrurj-171	2	60	or	or	CCONJ
arestyrurj-171	2	61	npc-2	npc-2	PRON
arestyrurj-171	2	62	protein	protein	NOUN
arestyrurj-171	2	63	is	be	AUX
arestyrurj-171	2	64	mutated	mutate	VERB
arestyrurj-171	2	65	,	,	PUNCT
arestyrurj-171	2	66	causing	cause	VERB
arestyrurj-171	2	67	cell	cell	NOUN
arestyrurj-171	2	68	lysosomes	lysosome	NOUN
arestyrurj-171	2	69	to	to	PART
arestyrurj-171	2	70	accumulate	accumulate	VERB
arestyrurj-171	2	71	cholesterol	cholesterol	NOUN
arestyrurj-171	2	72	and	and	CCONJ
arestyrurj-171	2	73	lipids	lipid	NOUN
arestyrurj-171	2	74	.	.	PUNCT
arestyrurj-171	3	1	previous	previous	ADJ
arestyrurj-171	3	2	studies	study	NOUN
arestyrurj-171	3	3	discovered	discover	VERB
arestyrurj-171	3	4	that	that	SCONJ
arestyrurj-171	3	5	a	a	DET
arestyrurj-171	3	6	unique	unique	ADJ
arestyrurj-171	3	7	late	late	ADJ
arestyrurj-171	3	8	endosomal	endosomal	ADJ
arestyrurj-171	3	9	/	/	SYM
arestyrurj-171	3	10	lysosomal	lysosomal	ADJ
arestyrurj-171	3	11	phospholipid	phospholipid	NOUN
arestyrurj-171	3	12	,	,	PUNCT
arestyrurj-171	3	13	lysobisphosphatidic	lysobisphosphatidic	ADJ
arestyrurj-171	3	14	acid	acid	NOUN
arestyrurj-171	3	15	(	(	PUNCT
arestyrurj-171	3	16	lpba	lpba	NOUN
arestyrurj-171	3	17	)	)	PUNCT
arestyrurj-171	3	18	,	,	PUNCT
arestyrurj-171	3	19	is	be	AUX
arestyrurj-171	3	20	involved	involve	VERB
arestyrurj-171	3	21	in	in	ADP
arestyrurj-171	3	22	cholesterol	cholesterol	NOUN
arestyrurj-171	3	23	clearance	clearance	NOUN
arestyrurj-171	3	24	from	from	ADP
arestyrurj-171	3	25	late	late	ADJ
arestyrurj-171	3	26	endosomes	endosome	NOUN
arestyrurj-171	3	27	.	.	PUNCT
arestyrurj-171	4	1	it	it	PRON
arestyrurj-171	4	2	has	have	AUX
arestyrurj-171	4	3	also	also	ADV
arestyrurj-171	4	4	been	be	AUX
arestyrurj-171	4	5	shown	show	VERB
arestyrurj-171	4	6	that	that	SCONJ
arestyrurj-171	4	7	exogenous	exogenous	ADJ
arestyrurj-171	4	8	treatment	treatment	NOUN
arestyrurj-171	4	9	of	of	ADP
arestyrurj-171	4	10	the	the	DET
arestyrurj-171	4	11	npc-1	npc-1	VERB
arestyrurj-171	4	12	deficient	deficient	ADJ
arestyrurj-171	4	13	cells	cell	NOUN
arestyrurj-171	4	14	with	with	ADP
arestyrurj-171	4	15	lbpa	lbpa	NOUN
arestyrurj-171	4	16	’s	’s	PART
arestyrurj-171	4	17	precursor	precursor	NOUN
arestyrurj-171	4	18	,	,	PUNCT
arestyrurj-171	4	19	phosphatidylglycerol	phosphatidylglycerol	NOUN
arestyrurj-171	4	20	(	(	PUNCT
arestyrurj-171	4	21	pg	pg	NOUN
arestyrurj-171	4	22	)	)	PUNCT
arestyrurj-171	4	23	,	,	PUNCT
arestyrurj-171	4	24	leads	lead	VERB
arestyrurj-171	4	25	to	to	ADP
arestyrurj-171	4	26	lbpa	lbpa	ADJ
arestyrurj-171	4	27	enrichment	enrichment	NOUN
arestyrurj-171	4	28	and	and	CCONJ
arestyrurj-171	4	29	subsequent	subsequent	ADJ
arestyrurj-171	4	30	endolysosomal	endolysosomal	ADJ
arestyrurj-171	4	31	cholesterol	cholesterol	NOUN
arestyrurj-171	4	32	clearance	clearance	NOUN
arestyrurj-171	4	33	.	.	PUNCT
arestyrurj-171	5	1	autophagy	autophagy	PROPN
arestyrurj-171	5	2	is	be	AUX
arestyrurj-171	5	3	a	a	DET
arestyrurj-171	5	4	mechanism	mechanism	NOUN
arestyrurj-171	5	5	of	of	ADP
arestyrurj-171	5	6	cellular	cellular	ADJ
arestyrurj-171	5	7	clearance	clearance	NOUN
arestyrurj-171	5	8	in	in	ADP
arestyrurj-171	5	9	the	the	DET
arestyrurj-171	5	10	endolysomal	endolysomal	ADJ
arestyrurj-171	5	11	system	system	NOUN
arestyrurj-171	5	12	and	and	CCONJ
arestyrurj-171	5	13	we	we	PRON
arestyrurj-171	5	14	are	be	AUX
arestyrurj-171	5	15	interested	interested	ADJ
arestyrurj-171	5	16	to	to	PART
arestyrurj-171	5	17	see	see	VERB
arestyrurj-171	5	18	if	if	SCONJ
arestyrurj-171	5	19	it	it	PRON
arestyrurj-171	5	20	is	be	AUX
arestyrurj-171	5	21	a	a	DET
arestyrurj-171	5	22	partial	partial	ADJ
arestyrurj-171	5	23	route	route	NOUN
arestyrurj-171	5	24	in	in	ADP
arestyrurj-171	5	25	cholesterol	cholesterol	NOUN
arestyrurj-171	5	26	clearance	clearance	NOUN
arestyrurj-171	5	27	during	during	ADP
arestyrurj-171	5	28	pg	pg	NOUN
arestyrurj-171	5	29	treatment	treatment	NOUN
arestyrurj-171	5	30	of	of	ADP
arestyrurj-171	5	31	npc-1	npc-1	NOUN
arestyrurj-171	5	32	deficient	deficient	ADJ
arestyrurj-171	5	33	cells	cell	NOUN
arestyrurj-171	5	34	.	.	PUNCT
arestyrurj-171	6	1	to	to	PART
arestyrurj-171	6	2	do	do	VERB
arestyrurj-171	6	3	so	so	ADV
arestyrurj-171	6	4	,	,	PUNCT
arestyrurj-171	6	5	we	we	PRON
arestyrurj-171	6	6	silenced	silence	VERB
arestyrurj-171	6	7	the	the	DET
arestyrurj-171	6	8	gene	gene	NOUN
arestyrurj-171	6	9	that	that	PRON
arestyrurj-171	6	10	codes	code	VERB
arestyrurj-171	6	11	for	for	ADP
arestyrurj-171	6	12	an	an	DET
arestyrurj-171	6	13	essential	essential	ADJ
arestyrurj-171	6	14	protein	protein	NOUN
arestyrurj-171	6	15	in	in	ADP
arestyrurj-171	6	16	the	the	DET
arestyrurj-171	6	17	autophagy	autophagy	ADJ
arestyrurj-171	6	18	pathway	pathway	NOUN
arestyrurj-171	6	19	,	,	PUNCT
arestyrurj-171	6	20	making	make	VERB
arestyrurj-171	6	21	the	the	DET
arestyrurj-171	6	22	cells	cell	NOUN
arestyrurj-171	6	23	autophagy	autophagy	ADV
arestyrurj-171	6	24	deficient	deficient	ADJ
arestyrurj-171	6	25	.	.	PUNCT
arestyrurj-171	7	1	we	we	PRON
arestyrurj-171	7	2	then	then	ADV
arestyrurj-171	7	3	treated	treat	VERB
arestyrurj-171	7	4	the	the	DET
arestyrurj-171	7	5	cells	cell	NOUN
arestyrurj-171	7	6	with	with	ADP
arestyrurj-171	7	7	pg	pg	PROPN
arestyrurj-171	7	8	,	,	PUNCT
arestyrurj-171	7	9	measured	measure	VERB
arestyrurj-171	7	10	the	the	DET
arestyrurj-171	7	11	amount	amount	NOUN
arestyrurj-171	7	12	of	of	ADP
arestyrurj-171	7	13	cholesterol	cholesterol	NOUN
arestyrurj-171	7	14	clearance	clearance	NOUN
arestyrurj-171	7	15	in	in	ADP
arestyrurj-171	7	16	those	those	DET
arestyrurj-171	7	17	cells	cell	NOUN
arestyrurj-171	7	18	,	,	PUNCT
arestyrurj-171	7	19	and	and	CCONJ
arestyrurj-171	7	20	compared	compare	VERB
arestyrurj-171	7	21	it	it	PRON
arestyrurj-171	7	22	to	to	ADP
arestyrurj-171	7	23	cells	cell	NOUN
arestyrurj-171	7	24	with	with	ADP
arestyrurj-171	7	25	normal	normal	ADJ
arestyrurj-171	7	26	autophagy	autophagy	NOUN
arestyrurj-171	7	27	.	.	PUNCT
arestyrurj-171	8	1	we	we	PRON
arestyrurj-171	8	2	found	find	VERB
arestyrurj-171	8	3	significantly	significantly	ADV
arestyrurj-171	8	4	less	less	ADJ
arestyrurj-171	8	5	cholesterol	cholesterol	NOUN
arestyrurj-171	8	6	clearance	clearance	NOUN
arestyrurj-171	8	7	by	by	ADP
arestyrurj-171	8	8	pg	pg	NOUN
arestyrurj-171	8	9	in	in	ADP
arestyrurj-171	8	10	cells	cell	NOUN
arestyrurj-171	8	11	with	with	ADP
arestyrurj-171	8	12	defective	defective	ADJ
arestyrurj-171	8	13	autophagy	autophagy	NOUN
arestyrurj-171	8	14	,	,	PUNCT
arestyrurj-171	8	15	confirming	confirm	VERB
arestyrurj-171	8	16	that	that	SCONJ
arestyrurj-171	8	17	autophagy	autophagy	NOUN
arestyrurj-171	8	18	is	be	AUX
arestyrurj-171	8	19	involved	involve	VERB
arestyrurj-171	8	20	as	as	ADP
arestyrurj-171	8	21	a	a	DET
arestyrurj-171	8	22	partial	partial	ADJ
arestyrurj-171	8	23	route	route	NOUN
arestyrurj-171	8	24	in	in	ADP
arestyrurj-171	8	25	cholesterol	cholesterol	NOUN
arestyrurj-171	8	26	clearance	clearance	NOUN
arestyrurj-171	8	27	during	during	ADP
arestyrurj-171	8	28	pg	pg	NOUN
arestyrurj-171	8	29	treatment	treatment	NOUN
arestyrurj-171	8	30	,	,	PUNCT
arestyrurj-171	8	31	but	but	CCONJ
arestyrurj-171	8	32	not	not	PART
arestyrurj-171	8	33	enough	enough	ADJ
arestyrurj-171	8	34	of	of	ADP
arestyrurj-171	8	35	a	a	DET
arestyrurj-171	8	36	difference	difference	NOUN
arestyrurj-171	8	37	to	to	PART
arestyrurj-171	8	38	conclude	conclude	VERB
arestyrurj-171	8	39	that	that	SCONJ
arestyrurj-171	8	40	it	it	PRON
arestyrurj-171	8	41	is	be	AUX
arestyrurj-171	8	42	a	a	DET
arestyrurj-171	8	43	major	major	ADJ
arestyrurj-171	8	44	underlying	underlying	ADJ
arestyrurj-171	8	45	mechanism	mechanism	NOUN
arestyrurj-171	8	46	.	.	PUNCT
arestyrurj-171	9	1	1	1	NUM
arestyrurj-171	9	2	introduction	introduction	NOUN
arestyrurj-171	9	3	niemann	niemann	PROPN
arestyrurj-171	9	4	pick	pick	PROPN
arestyrurj-171	9	5	type	type	NOUN
arestyrurj-171	9	6	c	c	PROPN
arestyrurj-171	9	7	(	(	PUNCT
arestyrurj-171	9	8	npc	npc	NOUN
arestyrurj-171	9	9	)	)	PUNCT
arestyrurj-171	9	10	disease	disease	NOUN
arestyrurj-171	9	11	results	result	VERB
arestyrurj-171	9	12	in	in	ADP
arestyrurj-171	9	13	cholesterol	cholesterol	NOUN
arestyrurj-171	9	14	and	and	CCONJ
arestyrurj-171	9	15	lipids	lipid	NOUN
arestyrurj-171	9	16	becoming	becoming	AUX
arestyrurj-171	9	17	trapped	trap	VERB
arestyrurj-171	9	18	in	in	ADP
arestyrurj-171	9	19	cell	cell	NOUN
arestyrurj-171	9	20	lysosomes	lysosome	NOUN
arestyrurj-171	9	21	and	and	CCONJ
arestyrurj-171	9	22	unable	unable	ADJ
arestyrurj-171	9	23	to	to	PART
arestyrurj-171	9	24	be	be	AUX
arestyrurj-171	9	25	trafficked	traffic	VERB
arestyrurj-171	9	26	through	through	ADP
arestyrurj-171	9	27	the	the	DET
arestyrurj-171	9	28	cell	cell	NOUN
arestyrurj-171	9	29	to	to	ADP
arestyrurj-171	9	30	where	where	SCONJ
arestyrurj-171	9	31	they	they	PRON
arestyrurj-171	9	32	are	be	AUX
arestyrurj-171	9	33	needed.[19,26	needed.[19,26	NOUN
arestyrurj-171	9	34	]	]	X
arestyrurj-171	9	35	cholesterol	cholesterol	NOUN
arestyrurj-171	9	36	accumulates	accumulate	VERB
arestyrurj-171	9	37	in	in	ADP
arestyrurj-171	9	38	the	the	DET
arestyrurj-171	9	39	lysosome	lysosome	NOUN
arestyrurj-171	9	40	and	and	CCONJ
arestyrurj-171	9	41	exits	exit	NOUN
arestyrurj-171	9	42	via	via	ADP
arestyrurj-171	9	43	lysosomal	lysosomal	ADJ
arestyrurj-171	9	44	membrane	membrane	NOUN
arestyrurj-171	9	45	proteins	protein	NOUN
arestyrurj-171	9	46	,	,	PUNCT
arestyrurj-171	9	47	such	such	ADJ
arestyrurj-171	9	48	as	as	ADP
arestyrurj-171	9	49	npc-1	npc-1	NOUN
arestyrurj-171	9	50	and	and	CCONJ
arestyrurj-171	9	51	npc-2	npc-2	NOUN
arestyrurj-171	9	52	,	,	PUNCT
arestyrurj-171	9	53	in	in	ADP
arestyrurj-171	9	54	unaffected	unaffected	ADJ
arestyrurj-171	9	55	cells	cell	NOUN
arestyrurj-171	9	56	.	.	PUNCT
arestyrurj-171	10	1	the	the	DET
arestyrurj-171	10	2	npc	npc	NOUN
arestyrurj-171	10	3	proteins	protein	NOUN
arestyrurj-171	10	4	are	be	AUX
arestyrurj-171	10	5	essential	essential	ADJ
arestyrurj-171	10	6	for	for	ADP
arestyrurj-171	10	7	transporting	transport	VERB
arestyrurj-171	10	8	cholesterol	cholesterol	NOUN
arestyrurj-171	10	9	through	through	ADP
arestyrurj-171	10	10	the	the	DET
arestyrurj-171	10	11	endolysosomal	endolysosomal	ADJ
arestyrurj-171	10	12	system	system	NOUN
arestyrurj-171	10	13	;	;	PUNCT
arestyrurj-171	10	14	therefore	therefore	ADV
arestyrurj-171	10	15	,	,	PUNCT
arestyrurj-171	10	16	nonfunctional	nonfunctional	ADJ
arestyrurj-171	10	17	npc	npc	NOUN
arestyrurj-171	10	18	proteins	protein	NOUN
arestyrurj-171	10	19	result	result	VERB
arestyrurj-171	10	20	in	in	ADP
arestyrurj-171	10	21	an	an	DET
arestyrurj-171	10	22	accumulation	accumulation	NOUN
arestyrurj-171	10	23	of	of	ADP
arestyrurj-171	10	24	cholesterol	cholesterol	NOUN
arestyrurj-171	10	25	and	and	CCONJ
arestyrurj-171	10	26	secondary	secondary	ADJ
arestyrurj-171	10	27	lipids	lipid	NOUN
arestyrurj-171	10	28	in	in	ADP
arestyrurj-171	10	29	the	the	DET
arestyrurj-171	10	30	late	late	ADJ
arestyrurj-171	10	31	endosomal	endosomal	ADJ
arestyrurj-171	10	32	and	and	CCONJ
arestyrurj-171	10	33	lysosomal	lysosomal	ADJ
arestyrurj-171	10	34	compartments	compartment	NOUN
arestyrurj-171	10	35	.	.	PUNCT
arestyrurj-171	11	1	an	an	DET
arestyrurj-171	11	2	npc	npc	NOUN
arestyrurj-171	11	3	patient	patient	NOUN
arestyrurj-171	11	4	suffers	suffer	VERB
arestyrurj-171	11	5	from	from	ADP
arestyrurj-171	11	6	severe	severe	ADJ
arestyrurj-171	11	7	motor	motor	NOUN
arestyrurj-171	11	8	and	and	CCONJ
arestyrurj-171	11	9	neurological	neurological	ADJ
arestyrurj-171	11	10	symptoms	symptom	NOUN
arestyrurj-171	11	11	that	that	PRON
arestyrurj-171	11	12	worsen	worsen	VERB
arestyrurj-171	11	13	with	with	ADP
arestyrurj-171	11	14	time.[14	time.[14	PROPN
arestyrurj-171	11	15	]	]	X
arestyrurj-171	11	16	the	the	DET
arestyrurj-171	11	17	exact	exact	ADJ
arestyrurj-171	11	18	method	method	NOUN
arestyrurj-171	11	19	of	of	ADP
arestyrurj-171	11	20	how	how	SCONJ
arestyrurj-171	11	21	cholesterol	cholesterol	NOUN
arestyrurj-171	11	22	is	be	AUX
arestyrurj-171	11	23	transported	transport	VERB
arestyrurj-171	11	24	out	out	ADP
arestyrurj-171	11	25	of	of	ADP
arestyrurj-171	11	26	the	the	DET
arestyrurj-171	11	27	endolysosomal	endolysosomal	ADJ
arestyrurj-171	11	28	system	system	NOUN
arestyrurj-171	11	29	is	be	AUX
arestyrurj-171	11	30	unknown,[14	unknown,[14	VERB
arestyrurj-171	11	31	]	]	PUNCT
arestyrurj-171	11	32	but	but	CCONJ
arestyrurj-171	11	33	our	our	PRON
arestyrurj-171	11	34	preliminary	preliminary	ADJ
arestyrurj-171	11	35	data	datum	NOUN
arestyrurj-171	11	36	suggests	suggest	VERB
arestyrurj-171	11	37	that	that	SCONJ
arestyrurj-171	11	38	autophagy	autophagy	NOUN
arestyrurj-171	11	39	may	may	AUX
arestyrurj-171	11	40	be	be	AUX
arestyrurj-171	11	41	involved	involve	VERB
arestyrurj-171	11	42	.	.	PUNCT
arestyrurj-171	12	1	autophagy	autophagy	NOUN
arestyrurj-171	12	2	is	be	AUX
arestyrurj-171	12	3	a	a	DET
arestyrurj-171	12	4	mechanism	mechanism	NOUN
arestyrurj-171	12	5	of	of	ADP
arestyrurj-171	12	6	cellular	cellular	ADJ
arestyrurj-171	12	7	clearance	clearance	NOUN
arestyrurj-171	12	8	in	in	ADP
arestyrurj-171	12	9	which	which	PRON
arestyrurj-171	12	10	damaged	damage	VERB
arestyrurj-171	12	11	proteins	protein	NOUN
arestyrurj-171	12	12	,	,	PUNCT
arestyrurj-171	12	13	organelles	organelle	NOUN
arestyrurj-171	12	14	,	,	PUNCT
arestyrurj-171	12	15	and	and	CCONJ
arestyrurj-171	12	16	membranes	membrane	NOUN
arestyrurj-171	12	17	are	be	AUX
arestyrurj-171	12	18	transported	transport	VERB
arestyrurj-171	12	19	to	to	ADP
arestyrurj-171	12	20	the	the	DET
arestyrurj-171	12	21	endolysosomal	endolysosomal	ADJ
arestyrurj-171	12	22	system	system	NOUN
arestyrurj-171	12	23	where	where	SCONJ
arestyrurj-171	12	24	they	they	PRON
arestyrurj-171	12	25	can	can	AUX
arestyrurj-171	12	26	be	be	AUX
arestyrurj-171	12	27	broken	break	VERB
arestyrurj-171	12	28	down	down	ADP
arestyrurj-171	12	29	into	into	ADP
arestyrurj-171	12	30	metabolites	metabolite	NOUN
arestyrurj-171	12	31	used	use	VERB
arestyrurj-171	12	32	by	by	ADP
arestyrurj-171	12	33	the	the	DET
arestyrurj-171	12	34	cell.[28	cell.[28	PROPN
arestyrurj-171	12	35	]	]	X
arestyrurj-171	12	36	it	it	PRON
arestyrurj-171	12	37	is	be	AUX
arestyrurj-171	12	38	essentially	essentially	ADV
arestyrurj-171	12	39	a	a	DET
arestyrurj-171	12	40	cellular	cellular	ADJ
arestyrurj-171	12	41	degradation	degradation	NOUN
arestyrurj-171	12	42	and	and	CCONJ
arestyrurj-171	12	43	recycling	recycling	NOUN
arestyrurj-171	12	44	process	process	NOUN
arestyrurj-171	12	45	.	.	PUNCT
arestyrurj-171	13	1	in	in	ADP
arestyrurj-171	13	2	order	order	NOUN
arestyrurj-171	13	3	for	for	SCONJ
arestyrurj-171	13	4	cells	cell	NOUN
arestyrurj-171	13	5	to	to	PART
arestyrurj-171	13	6	perform	perform	VERB
arestyrurj-171	13	7	essential	essential	ADJ
arestyrurj-171	13	8	biosynthetic	biosynthetic	ADJ
arestyrurj-171	13	9	and	and	CCONJ
arestyrurj-171	13	10	energy	energy	NOUN
arestyrurj-171	13	11	production	production	NOUN
arestyrurj-171	13	12	pathways	pathway	NOUN
arestyrurj-171	13	13	,	,	PUNCT
arestyrurj-171	13	14	they	they	PRON
arestyrurj-171	13	15	need	need	VERB
arestyrurj-171	13	16	basic	basic	ADJ
arestyrurj-171	13	17	monomers	monomer	NOUN
arestyrurj-171	13	18	of	of	ADP
arestyrurj-171	13	19	larger	large	ADJ
arestyrurj-171	13	20	molecules	molecule	NOUN
arestyrurj-171	13	21	.	.	PUNCT
arestyrurj-171	14	1	cells	cell	NOUN
arestyrurj-171	14	2	can	can	AUX
arestyrurj-171	14	3	obtain	obtain	VERB
arestyrurj-171	14	4	these	these	DET
arestyrurj-171	14	5	monomers	monomer	NOUN
arestyrurj-171	14	6	through	through	ADP
arestyrurj-171	14	7	the	the	DET
arestyrurj-171	14	8	break	break	NOUN
arestyrurj-171	14	9	-	-	PUNCT
arestyrurj-171	14	10	down	down	NOUN
arestyrurj-171	14	11	and	and	CCONJ
arestyrurj-171	14	12	recycling	recycling	NOUN
arestyrurj-171	14	13	of	of	ADP
arestyrurj-171	14	14	damaged	damaged	ADJ
arestyrurj-171	14	15	organelles	organelle	NOUN
arestyrurj-171	14	16	,	,	PUNCT
arestyrurj-171	14	17	proteins	protein	NOUN
arestyrurj-171	14	18	,	,	PUNCT
arestyrurj-171	14	19	and	and	CCONJ
arestyrurj-171	14	20	cellular	cellular	ADJ
arestyrurj-171	14	21	membranes	membrane	NOUN
arestyrurj-171	14	22	.	.	PUNCT
arestyrurj-171	15	1	these	these	DET
arestyrurj-171	15	2	molecular	molecular	ADJ
arestyrurj-171	15	3	degradations	degradation	NOUN
arestyrurj-171	15	4	occur	occur	VERB
arestyrurj-171	15	5	in	in	ADP
arestyrurj-171	15	6	lysosomes	lysosome	NOUN
arestyrurj-171	15	7	,	,	PUNCT
arestyrurj-171	15	8	which	which	PRON
arestyrurj-171	15	9	are	be	AUX
arestyrurj-171	15	10	acidic	acidic	ADJ
arestyrurj-171	15	11	vesicles	vesicle	NOUN
arestyrurj-171	15	12	containing	contain	VERB
arestyrurj-171	15	13	numerous	numerous	ADJ
arestyrurj-171	15	14	hydrolases	hydrolase	NOUN
arestyrurj-171	15	15	and	and	CCONJ
arestyrurj-171	15	16	found	find	VERB
arestyrurj-171	15	17	within	within	ADP
arestyrurj-171	15	18	the	the	DET
arestyrurj-171	15	19	cell	cell	NOUN
arestyrurj-171	15	20	.	.	PUNCT
arestyrurj-171	16	1	hydrolases	hydrolase	NOUN
arestyrurj-171	16	2	are	be	AUX
arestyrurj-171	16	3	a	a	DET
arestyrurj-171	16	4	class	class	NOUN
arestyrurj-171	16	5	of	of	ADP
arestyrurj-171	16	6	proteins	protein	NOUN
arestyrurj-171	16	7	that	that	PRON
arestyrurj-171	16	8	break	break	VERB
arestyrurj-171	16	9	down	down	ADP
arestyrurj-171	16	10	large	large	ADJ
arestyrurj-171	16	11	molecules	molecule	NOUN
arestyrurj-171	16	12	into	into	ADP
arestyrurj-171	16	13	their	their	PRON
arestyrurj-171	16	14	monomers	monomer	NOUN
arestyrurj-171	16	15	.	.	PUNCT
arestyrurj-171	17	1	macroautophagy	macroautophagy	ADJ
arestyrurj-171	17	2	involves	involve	VERB
arestyrurj-171	17	3	sequestering	sequester	VERB
arestyrurj-171	17	4	the	the	DET
arestyrurj-171	17	5	molecules	molecule	NOUN
arestyrurj-171	17	6	that	that	PRON
arestyrurj-171	17	7	need	need	VERB
arestyrurj-171	17	8	to	to	PART
arestyrurj-171	17	9	be	be	AUX
arestyrurj-171	17	10	degraded	degrade	VERB
arestyrurj-171	17	11	into	into	ADP
arestyrurj-171	17	12	vesicles	vesicle	NOUN
arestyrurj-171	17	13	called	call	VERB
arestyrurj-171	17	14	autophago	autophago	PROPN
arestyrurj-171	17	15	aresty	aresty	PROPN
arestyrurj-171	17	16	rutgers	rutgers	PROPN
arestyrurj-171	17	17	undergraduate	undergraduate	PROPN
arestyrurj-171	17	18	research	research	PROPN
arestyrurj-171	17	19	journal	journal	PROPN
arestyrurj-171	17	20	,	,	PUNCT
arestyrurj-171	17	21	volume	volume	NOUN
arestyrurj-171	17	22	i	i	PRON
arestyrurj-171	17	23	,	,	PUNCT
arestyrurj-171	17	24	issue	issue	VERB
arestyrurj-171	17	25	iii	iii	NUM
arestyrurj-171	17	26	somes	some	NOUN
arestyrurj-171	17	27	and	and	CCONJ
arestyrurj-171	17	28	delivering	deliver	VERB
arestyrurj-171	17	29	them	they	PRON
arestyrurj-171	17	30	to	to	ADP
arestyrurj-171	17	31	lysosomes	lysosome	NOUN
arestyrurj-171	17	32	for	for	ADP
arestyrurj-171	17	33	degradation,[28	degradation,[28	NOUN
arestyrurj-171	17	34	]	]	PUNCT
arestyrurj-171	17	35	as	as	SCONJ
arestyrurj-171	17	36	shown	show	VERB
arestyrurj-171	17	37	in	in	ADP
arestyrurj-171	17	38	figure	figure	NOUN
arestyrurj-171	17	39	1	1	NUM
arestyrurj-171	17	40	.	.	PUNCT
arestyrurj-171	18	1	the	the	DET
arestyrurj-171	18	2	process	process	NOUN
arestyrurj-171	18	3	of	of	ADP
arestyrurj-171	18	4	autophagy	autophagy	NOUN
arestyrurj-171	18	5	begins	begin	VERB
arestyrurj-171	18	6	with	with	ADP
arestyrurj-171	18	7	the	the	DET
arestyrurj-171	18	8	process	process	NOUN
arestyrurj-171	18	9	shown	show	VERB
arestyrurj-171	18	10	in	in	ADP
arestyrurj-171	18	11	figure	figure	NOUN
arestyrurj-171	18	12	2	2	NUM
arestyrurj-171	18	13	.	.	PUNCT
arestyrurj-171	18	14	several	several	ADJ
arestyrurj-171	18	15	molecules	molecule	NOUN
arestyrurj-171	18	16	come	come	VERB
arestyrurj-171	18	17	together	together	ADV
arestyrurj-171	18	18	to	to	PART
arestyrurj-171	18	19	form	form	VERB
arestyrurj-171	18	20	the	the	DET
arestyrurj-171	18	21	ulk1/2	ulk1/2	ADV
arestyrurj-171	18	22	-	-	PUNCT
arestyrurj-171	18	23	atg13	atg13	VERB
arestyrurj-171	18	24	-	-	PUNCT
arestyrurj-171	18	25	rb1cc1	rb1cc1	NOUN
arestyrurj-171	18	26	induction	induction	NOUN
arestyrurj-171	18	27	complex	complex	NOUN
arestyrurj-171	18	28	,	,	PUNCT
arestyrurj-171	18	29	which	which	PRON
arestyrurj-171	18	30	can	can	AUX
arestyrurj-171	18	31	develop	develop	VERB
arestyrurj-171	18	32	at	at	ADP
arestyrurj-171	18	33	multiple	multiple	ADJ
arestyrurj-171	18	34	sites	site	NOUN
arestyrurj-171	18	35	throughout	throughout	ADP
arestyrurj-171	18	36	the	the	DET
arestyrurj-171	18	37	cytoplasm.[5,10	cytoplasm.[5,10	NOUN
arestyrurj-171	18	38	]	]	PUNCT
arestyrurj-171	18	39	once	once	ADV
arestyrurj-171	18	40	formed	form	VERB
arestyrurj-171	18	41	,	,	PUNCT
arestyrurj-171	18	42	the	the	DET
arestyrurj-171	18	43	complex	complex	NOUN
arestyrurj-171	18	44	can	can	AUX
arestyrurj-171	18	45	either	either	CCONJ
arestyrurj-171	18	46	be	be	AUX
arestyrurj-171	18	47	activated	activate	VERB
arestyrurj-171	18	48	or	or	CCONJ
arestyrurj-171	18	49	inactivated	inactivate	VERB
arestyrurj-171	18	50	via	via	ADP
arestyrurj-171	18	51	a	a	DET
arestyrurj-171	18	52	molecule	molecule	NOUN
arestyrurj-171	18	53	called	call	VERB
arestyrurj-171	18	54	the	the	DET
arestyrurj-171	18	55	mechanistic	mechanistic	ADJ
arestyrurj-171	18	56	target	target	NOUN
arestyrurj-171	18	57	of	of	ADP
arestyrurj-171	18	58	rapamycin	rapamycin	NOUN
arestyrurj-171	18	59	complex	complex	ADJ
arestyrurj-171	18	60	1	1	NUM
arestyrurj-171	18	61	(	(	PUNCT
arestyrurj-171	18	62	mtorc1	mtorc1	NOUN
arestyrurj-171	18	63	)	)	PUNCT
arestyrurj-171	18	64	.	.	PUNCT
arestyrurj-171	19	1	when	when	SCONJ
arestyrurj-171	19	2	mtorc1	mtorc1	NOUN
arestyrurj-171	19	3	is	be	AUX
arestyrurj-171	19	4	associated	associate	VERB
arestyrurj-171	19	5	with	with	ADP
arestyrurj-171	19	6	the	the	DET
arestyrurj-171	19	7	induction	induction	NOUN
arestyrurj-171	19	8	complex	complex	NOUN
arestyrurj-171	19	9	,	,	PUNCT
arestyrurj-171	19	10	the	the	DET
arestyrurj-171	19	11	complex	complex	NOUN
arestyrurj-171	19	12	is	be	AUX
arestyrurj-171	19	13	inactive	inactive	ADJ
arestyrurj-171	19	14	and	and	CCONJ
arestyrurj-171	19	15	the	the	DET
arestyrurj-171	19	16	process	process	NOUN
arestyrurj-171	19	17	of	of	ADP
arestyrurj-171	19	18	autophagy	autophagy	ADJ
arestyrurj-171	19	19	stops	stop	NOUN
arestyrurj-171	19	20	.	.	PUNCT
arestyrurj-171	20	1	when	when	SCONJ
arestyrurj-171	20	2	mtorc1	mtorc1	NOUN
arestyrurj-171	20	3	dissociates	dissociate	NOUN
arestyrurj-171	20	4	from	from	ADP
arestyrurj-171	20	5	the	the	DET
arestyrurj-171	20	6	induction	induction	NOUN
arestyrurj-171	20	7	complex	complex	NOUN
arestyrurj-171	20	8	,	,	PUNCT
arestyrurj-171	20	9	the	the	DET
arestyrurj-171	20	10	complex	complex	NOUN
arestyrurj-171	20	11	activates	activate	VERB
arestyrurj-171	20	12	,	,	PUNCT
arestyrurj-171	20	13	resuming	resume	VERB
arestyrurj-171	20	14	autophagy.[9	autophagy.[9	NUM
arestyrurj-171	20	15	]	]	PUNCT
arestyrurj-171	20	16	to	to	PART
arestyrurj-171	20	17	summarize	summarize	VERB
arestyrurj-171	20	18	,	,	PUNCT
arestyrurj-171	20	19	the	the	DET
arestyrurj-171	20	20	process	process	NOUN
arestyrurj-171	20	21	of	of	ADP
arestyrurj-171	20	22	autophagy	autophagy	NOUN
arestyrurj-171	20	23	is	be	AUX
arestyrurj-171	20	24	inhibited	inhibit	VERB
arestyrurj-171	20	25	when	when	SCONJ
arestyrurj-171	20	26	mtorc1	mtorc1	NOUN
arestyrurj-171	20	27	is	be	AUX
arestyrurj-171	20	28	associated	associate	VERB
arestyrurj-171	20	29	with	with	ADP
arestyrurj-171	20	30	the	the	DET
arestyrurj-171	20	31	ulk1/2atg13	ulk1/2atg13	ADJ
arestyrurj-171	20	32	-	-	ADJ
arestyrurj-171	20	33	rb1cc1	rb1cc1	NOUN
arestyrurj-171	20	34	induction	induction	NOUN
arestyrurj-171	20	35	complex	complex	NOUN
arestyrurj-171	20	36	and	and	CCONJ
arestyrurj-171	20	37	resumes	resume	VERB
arestyrurj-171	20	38	when	when	SCONJ
arestyrurj-171	20	39	mtorc1	mtorc1	PROPN
arestyrurj-171	20	40	disassociates	disassociate	VERB
arestyrurj-171	20	41	from	from	ADP
arestyrurj-171	20	42	the	the	DET
arestyrurj-171	20	43	induction	induction	NOUN
arestyrurj-171	20	44	complex	complex	NOUN
arestyrurj-171	20	45	.	.	PUNCT
arestyrurj-171	21	1	in	in	ADP
arestyrurj-171	21	2	addition	addition	NOUN
arestyrurj-171	21	3	,	,	PUNCT
arestyrurj-171	21	4	figure	figure	NOUN
arestyrurj-171	21	5	2	2	NUM
arestyrurj-171	21	6	displays	display	VERB
arestyrurj-171	21	7	how	how	SCONJ
arestyrurj-171	21	8	the	the	DET
arestyrurj-171	21	9	nutrient	nutrient	ADJ
arestyrurj-171	21	10	status	status	NOUN
arestyrurj-171	21	11	of	of	ADP
arestyrurj-171	21	12	the	the	DET
arestyrurj-171	21	13	cell	cell	NOUN
arestyrurj-171	21	14	is	be	AUX
arestyrurj-171	21	15	involved	involve	VERB
arestyrurj-171	21	16	in	in	ADP
arestyrurj-171	21	17	autophagy	autophagy	ADJ
arestyrurj-171	21	18	regulation	regulation	NOUN
arestyrurj-171	21	19	.	.	PUNCT
arestyrurj-171	22	1	during	during	ADP
arestyrurj-171	22	2	nutrient	nutrient	ADJ
arestyrurj-171	22	3	starvation	starvation	NOUN
arestyrurj-171	22	4	,	,	PUNCT
arestyrurj-171	22	5	there	there	PRON
arestyrurj-171	22	6	is	be	VERB
arestyrurj-171	22	7	low	low	ADJ
arestyrurj-171	22	8	energy	energy	NOUN
arestyrurj-171	22	9	in	in	ADP
arestyrurj-171	22	10	the	the	DET
arestyrurj-171	22	11	cell	cell	NOUN
arestyrurj-171	22	12	.	.	PUNCT
arestyrurj-171	23	1	the	the	DET
arestyrurj-171	23	2	nutrition	nutrition	NOUN
arestyrurj-171	23	3	status	status	NOUN
arestyrurj-171	23	4	therefore	therefore	ADV
arestyrurj-171	23	5	determines	determine	VERB
arestyrurj-171	23	6	the	the	DET
arestyrurj-171	23	7	status	status	NOUN
arestyrurj-171	23	8	of	of	ADP
arestyrurj-171	23	9	autophagy	autophagy	NOUN
arestyrurj-171	23	10	,	,	PUNCT
arestyrurj-171	23	11	as	as	SCONJ
arestyrurj-171	23	12	the	the	DET
arestyrurj-171	23	13	cell	cell	NOUN
arestyrurj-171	23	14	needs	need	VERB
arestyrurj-171	23	15	the	the	DET
arestyrurj-171	23	16	monomers	monomer	NOUN
arestyrurj-171	23	17	produced	produce	VERB
arestyrurj-171	23	18	by	by	ADP
arestyrurj-171	23	19	autophagy	autophagy	NOUN
arestyrurj-171	23	20	for	for	ADP
arestyrurj-171	23	21	the	the	DET
arestyrurj-171	23	22	energy	energy	NOUN
arestyrurj-171	23	23	production	production	NOUN
arestyrurj-171	23	24	pathways.[9	pathways.[9	ADV
arestyrurj-171	23	25	]	]	PUNCT
arestyrurj-171	23	26	during	during	ADP
arestyrurj-171	23	27	nutrient	nutrient	ADJ
arestyrurj-171	23	28	enrichment	enrichment	NOUN
arestyrurj-171	23	29	,	,	PUNCT
arestyrurj-171	23	30	there	there	PRON
arestyrurj-171	23	31	is	be	VERB
arestyrurj-171	23	32	enough	enough	ADJ
arestyrurj-171	23	33	energy	energy	NOUN
arestyrurj-171	23	34	in	in	ADP
arestyrurj-171	23	35	the	the	DET
arestyrurj-171	23	36	cell	cell	NOUN
arestyrurj-171	23	37	and	and	CCONJ
arestyrurj-171	23	38	autophagy	autophagy	NOUN
arestyrurj-171	23	39	is	be	AUX
arestyrurj-171	23	40	not	not	PART
arestyrurj-171	23	41	needed	need	VERB
arestyrurj-171	23	42	.	.	PUNCT
arestyrurj-171	24	1	the	the	DET
arestyrurj-171	24	2	next	next	ADJ
arestyrurj-171	24	3	step	step	NOUN
arestyrurj-171	24	4	of	of	ADP
arestyrurj-171	24	5	autophagy	autophagy	NOUN
arestyrurj-171	24	6	is	be	AUX
arestyrurj-171	24	7	nucleation	nucleation	NOUN
arestyrurj-171	24	8	,	,	PUNCT
arestyrurj-171	24	9	or	or	CCONJ
arestyrurj-171	24	10	formation	formation	NOUN
arestyrurj-171	24	11	of	of	ADP
arestyrurj-171	24	12	the	the	DET
arestyrurj-171	24	13	membrane	membrane	NOUN
arestyrurj-171	24	14	,	,	PUNCT
arestyrurj-171	24	15	which	which	PRON
arestyrurj-171	24	16	is	be	AUX
arestyrurj-171	24	17	an	an	DET
arestyrurj-171	24	18	essential	essential	ADJ
arestyrurj-171	24	19	step	step	NOUN
arestyrurj-171	24	20	in	in	ADP
arestyrurj-171	24	21	macroautophagy.[18	macroautophagy.[18	PROPN
arestyrurj-171	24	22	]	]	PUNCT
arestyrurj-171	24	23	once	once	SCONJ
arestyrurj-171	24	24	the	the	DET
arestyrurj-171	24	25	membrane	membrane	NOUN
arestyrurj-171	24	26	begins	begin	VERB
arestyrurj-171	24	27	to	to	PART
arestyrurj-171	24	28	expand	expand	VERB
arestyrurj-171	24	29	,	,	PUNCT
arestyrurj-171	24	30	it	it	PRON
arestyrurj-171	24	31	is	be	AUX
arestyrurj-171	24	32	called	call	VERB
arestyrurj-171	24	33	a	a	DET
arestyrurj-171	24	34	phagophore	phagophore	NOUN
arestyrurj-171	24	35	.	.	PUNCT
arestyrurj-171	25	1	this	this	DET
arestyrurj-171	25	2	structure	structure	NOUN
arestyrurj-171	25	3	is	be	AUX
arestyrurj-171	25	4	double	double	ADV
arestyrurj-171	25	5	membranous	membranous	ADJ
arestyrurj-171	25	6	and	and	CCONJ
arestyrurj-171	25	7	expands	expand	VERB
arestyrurj-171	25	8	to	to	PART
arestyrurj-171	25	9	eventually	eventually	ADV
arestyrurj-171	25	10	create	create	VERB
arestyrurj-171	25	11	a	a	DET
arestyrurj-171	25	12	closed	closed	ADJ
arestyrurj-171	25	13	,	,	PUNCT
arestyrurj-171	25	14	circular	circular	ADJ
arestyrurj-171	25	15	vesicle.[8	vesicle.[8	NOUN
arestyrurj-171	25	16	]	]	X
arestyrurj-171	25	17	the	the	DET
arestyrurj-171	25	18	process	process	NOUN
arestyrurj-171	25	19	of	of	ADP
arestyrurj-171	25	20	phagophore	phagophore	ADJ
arestyrurj-171	25	21	elongation	elongation	NOUN
arestyrurj-171	25	22	is	be	AUX
arestyrurj-171	25	23	composed	compose	VERB
arestyrurj-171	25	24	of	of	ADP
arestyrurj-171	25	25	2	2	NUM
arestyrurj-171	25	26	conjugated	conjugate	VERB
arestyrurj-171	25	27	systems	system	NOUN
arestyrurj-171	25	28	.	.	PUNCT
arestyrurj-171	26	1	the	the	DET
arestyrurj-171	26	2	first	first	ADJ
arestyrurj-171	26	3	system	system	NOUN
arestyrurj-171	26	4	results	result	VERB
arestyrurj-171	26	5	in	in	ADP
arestyrurj-171	26	6	the	the	DET
arestyrurj-171	26	7	formation	formation	NOUN
arestyrurj-171	26	8	of	of	ADP
arestyrurj-171	26	9	the	the	DET
arestyrurj-171	26	10	atg12	atg12	PROPN
arestyrurj-171	26	11	-	-	PUNCT
arestyrurj-171	26	12	atg5	atg5	NOUN
arestyrurj-171	26	13	-	-	PUNCT
arestyrurj-171	26	14	atg16l1	atg16l1	PROPN
arestyrurj-171	26	15	complex	complex	NOUN
arestyrurj-171	26	16	,	,	PUNCT
arestyrurj-171	26	17	as	as	SCONJ
arestyrurj-171	26	18	shown	show	VERB
arestyrurj-171	26	19	in	in	ADP
arestyrurj-171	26	20	figure	figure	NOUN
arestyrurj-171	26	21	3	3	NUM
arestyrurj-171	26	22	,	,	PUNCT
arestyrurj-171	26	23	which	which	PRON
arestyrurj-171	26	24	is	be	AUX
arestyrurj-171	26	25	needed	need	VERB
arestyrurj-171	26	26	for	for	ADP
arestyrurj-171	26	27	the	the	DET
arestyrurj-171	26	28	second	second	ADJ
arestyrurj-171	26	29	system	system	NOUN
arestyrurj-171	26	30	.	.	PUNCT
arestyrurj-171	27	1	once	once	ADV
arestyrurj-171	27	2	formed	form	VERB
arestyrurj-171	27	3	,	,	PUNCT
arestyrurj-171	27	4	the	the	DET
arestyrurj-171	27	5	complex	complex	ADJ
arestyrurj-171	27	6	associates	associate	NOUN
arestyrurj-171	27	7	with	with	ADP
arestyrurj-171	27	8	the	the	DET
arestyrurj-171	27	9	phagophore	phagophore	NOUN
arestyrurj-171	27	10	membrane.[15,16	membrane.[15,16	NOUN
arestyrurj-171	27	11	]	]	PUNCT
arestyrurj-171	27	12	the	the	DET
arestyrurj-171	27	13	second	second	ADJ
arestyrurj-171	27	14	system	system	NOUN
arestyrurj-171	27	15	is	be	AUX
arestyrurj-171	27	16	shown	show	VERB
arestyrurj-171	27	17	in	in	ADP
arestyrurj-171	27	18	figure	figure	NOUN
arestyrurj-171	27	19	4	4	NUM
arestyrurj-171	27	20	and	and	CCONJ
arestyrurj-171	27	21	ultimately	ultimately	ADV
arestyrurj-171	27	22	allows	allow	VERB
arestyrurj-171	27	23	the	the	DET
arestyrurj-171	27	24	phagophore	phagophore	ADJ
arestyrurj-171	27	25	membrane	membrane	NOUN
arestyrurj-171	27	26	to	to	AUX
arestyrurj-171	27	27	elongate	elongate	VERB
arestyrurj-171	27	28	and	and	CCONJ
arestyrurj-171	27	29	move	move	VERB
arestyrurj-171	27	30	locations	location	NOUN
arestyrurj-171	27	31	within	within	ADP
arestyrurj-171	27	32	the	the	DET
arestyrurj-171	27	33	cell.[18	cell.[18	NOUN
arestyrurj-171	27	34	]	]	X
arestyrurj-171	27	35	one	one	NUM
arestyrurj-171	27	36	step	step	NOUN
arestyrurj-171	27	37	in	in	ADP
arestyrurj-171	27	38	this	this	DET
arestyrurj-171	27	39	process	process	NOUN
arestyrurj-171	27	40	is	be	AUX
arestyrurj-171	27	41	facilitated	facilitate	VERB
arestyrurj-171	27	42	by	by	ADP
arestyrurj-171	27	43	the	the	DET
arestyrurj-171	27	44	atg12	atg12	PROPN
arestyrurj-171	27	45	-	-	PUNCT
arestyrurj-171	27	46	atg5	atg5	NOUN
arestyrurj-171	27	47	-	-	PUNCT
arestyrurj-171	27	48	atg16l1	atg16l1	PROPN
arestyrurj-171	27	49	complex	complex	NOUN
arestyrurj-171	27	50	formed	form	VERB
arestyrurj-171	27	51	in	in	ADP
arestyrurj-171	27	52	the	the	DET
arestyrurj-171	27	53	first	first	ADJ
arestyrurj-171	27	54	system	system	NOUN
arestyrurj-171	27	55	.	.	PUNCT
arestyrurj-171	28	1	as	as	SCONJ
arestyrurj-171	28	2	the	the	DET
arestyrurj-171	28	3	phagophore	phagophore	ADJ
arestyrurj-171	28	4	membrane	membrane	NOUN
arestyrurj-171	28	5	expands	expand	VERB
arestyrurj-171	28	6	,	,	PUNCT
arestyrurj-171	28	7	it	it	PRON
arestyrurj-171	28	8	curves	curve	VERB
arestyrurj-171	28	9	around	around	ADP
arestyrurj-171	28	10	its	its	PRON
arestyrurj-171	28	11	target	target	NOUN
arestyrurj-171	28	12	molecules	molecule	NOUN
arestyrurj-171	28	13	,	,	PUNCT
arestyrurj-171	28	14	figure	figure	NOUN
arestyrurj-171	28	15	1	1	NUM
arestyrurj-171	28	16	:	:	PUNCT
arestyrurj-171	28	17	overview	overview	NOUN
arestyrurj-171	28	18	of	of	ADP
arestyrurj-171	28	19	macroautophagy	macroautophagy	ADJ
arestyrurj-171	28	20	in	in	ADP
arestyrurj-171	28	21	mammalian	mammalian	ADJ
arestyrurj-171	28	22	cells	cell	NOUN
arestyrurj-171	28	23	.	.	PUNCT
arestyrurj-171	29	1	figure	figure	NOUN
arestyrurj-171	29	2	obtained	obtain	VERB
arestyrurj-171	29	3	from	from	ADP
arestyrurj-171	29	4	[	[	X
arestyrurj-171	29	5	18	18	NUM
arestyrurj-171	29	6	]	]	PUNCT
arestyrurj-171	29	7	.	.	PUNCT
arestyrurj-171	30	1	figure	figure	NOUN
arestyrurj-171	30	2	2	2	NUM
arestyrurj-171	30	3	:	:	PUNCT
arestyrurj-171	30	4	activation	activation	NOUN
arestyrurj-171	30	5	of	of	ADP
arestyrurj-171	30	6	the	the	DET
arestyrurj-171	30	7	induction	induction	NOUN
arestyrurj-171	30	8	complex	complex	NOUN
arestyrurj-171	30	9	during	during	ADP
arestyrurj-171	30	10	a	a	DET
arestyrurj-171	30	11	nutrient	nutrient	NOUN
arestyrurj-171	30	12	starved	starve	VERB
arestyrurj-171	30	13	cellular	cellular	ADJ
arestyrurj-171	30	14	state	state	NOUN
arestyrurj-171	30	15	.	.	PUNCT
arestyrurj-171	31	1	figure	figure	NOUN
arestyrurj-171	31	2	obtained	obtain	VERB
arestyrurj-171	31	3	from	from	ADP
arestyrurj-171	31	4	[	[	X
arestyrurj-171	31	5	18	18	NUM
arestyrurj-171	31	6	]	]	PUNCT
arestyrurj-171	31	7	.	.	PUNCT
arestyrurj-171	32	1	figure	figure	VERB
arestyrurj-171	32	2	3	3	NUM
arestyrurj-171	32	3	:	:	PUNCT
arestyrurj-171	32	4	(	(	PUNCT
arestyrurj-171	32	5	left	left	ADJ
arestyrurj-171	32	6	)	)	PUNCT
arestyrurj-171	32	7	atg12	atg12	PROPN
arestyrurj-171	32	8	–	–	PUNCT
arestyrurj-171	32	9	atg5	atg5	NOUN
arestyrurj-171	32	10	-	-	PUNCT
arestyrurj-171	32	11	atg16l1	atg16l1	PROPN
arestyrurj-171	32	12	conjugation	conjugation	NOUN
arestyrurj-171	32	13	complex	complex	NOUN
arestyrurj-171	32	14	.	.	PUNCT
arestyrurj-171	33	1	figure	figure	NOUN
arestyrurj-171	33	2	obtained	obtain	VERB
arestyrurj-171	33	3	from	from	ADP
arestyrurj-171	33	4	[	[	X
arestyrurj-171	33	5	18	18	NUM
arestyrurj-171	33	6	]	]	PUNCT
arestyrurj-171	33	7	.	.	PUNCT
arestyrurj-171	34	1	figure	figure	VERB
arestyrurj-171	34	2	4	4	NUM
arestyrurj-171	34	3	:	:	PUNCT
arestyrurj-171	34	4	(	(	PUNCT
arestyrurj-171	34	5	right	right	ADJ
arestyrurj-171	34	6	)	)	PUNCT
arestyrurj-171	34	7	atg8	atg8	PROPN
arestyrurj-171	34	8	/	/	SYM
arestyrurj-171	34	9	lc3	lc3	NOUN
arestyrurj-171	34	10	conjugation	conjugation	NOUN
arestyrurj-171	34	11	system	system	NOUN
arestyrurj-171	34	12	.	.	PUNCT
arestyrurj-171	35	1	figure	figure	NOUN
arestyrurj-171	35	2	obtained	obtain	VERB
arestyrurj-171	35	3	from	from	ADP
arestyrurj-171	35	4	[	[	X
arestyrurj-171	35	5	18	18	NUM
arestyrurj-171	35	6	]	]	PUNCT
arestyrurj-171	35	7	.	.	PUNCT
arestyrurj-171	36	1	aresty	aresty	PROPN
arestyrurj-171	36	2	rutgers	rutgers	PROPN
arestyrurj-171	36	3	undergraduate	undergraduate	PROPN
arestyrurj-171	36	4	research	research	PROPN
arestyrurj-171	36	5	journal	journal	PROPN
arestyrurj-171	36	6	,	,	PUNCT
arestyrurj-171	36	7	volume	volume	NOUN
arestyrurj-171	36	8	i	i	PRON
arestyrurj-171	36	9	,	,	PUNCT
arestyrurj-171	36	10	issue	issue	VERB
arestyrurj-171	36	11	iii	iii	NOUN
arestyrurj-171	36	12	known	know	VERB
arestyrurj-171	36	13	as	as	ADP
arestyrurj-171	36	14	cargo	cargo	NOUN
arestyrurj-171	36	15	,	,	PUNCT
arestyrurj-171	36	16	and	and	CCONJ
arestyrurj-171	36	17	keeps	keep	VERB
arestyrurj-171	36	18	adjusting	adjust	VERB
arestyrurj-171	36	19	to	to	AUX
arestyrurj-171	36	20	wrap	wrap	VERB
arestyrurj-171	36	21	around	around	ADP
arestyrurj-171	36	22	the	the	DET
arestyrurj-171	36	23	cargo.[18	cargo.[18	NOUN
arestyrurj-171	36	24	]	]	PUNCT
arestyrurj-171	36	25	when	when	SCONJ
arestyrurj-171	36	26	it	it	PRON
arestyrurj-171	36	27	has	have	AUX
arestyrurj-171	36	28	fully	fully	ADV
arestyrurj-171	36	29	wrapped	wrap	VERB
arestyrurj-171	36	30	around	around	ADP
arestyrurj-171	36	31	the	the	DET
arestyrurj-171	36	32	cargo	cargo	NOUN
arestyrurj-171	36	33	,	,	PUNCT
arestyrurj-171	36	34	the	the	DET
arestyrurj-171	36	35	ends	end	NOUN
arestyrurj-171	36	36	connect	connect	VERB
arestyrurj-171	36	37	,	,	PUNCT
arestyrurj-171	36	38	forming	form	VERB
arestyrurj-171	36	39	a	a	DET
arestyrurj-171	36	40	closed	closed	ADJ
arestyrurj-171	36	41	double	double	ADJ
arestyrurj-171	36	42	membranous	membranous	ADJ
arestyrurj-171	36	43	vesicle	vesicle	NOUN
arestyrurj-171	36	44	known	know	VERB
arestyrurj-171	36	45	as	as	ADP
arestyrurj-171	36	46	an	an	DET
arestyrurj-171	36	47	autophagosome.[18	autophagosome.[18	PROPN
arestyrurj-171	36	48	]	]	PUNCT
arestyrurj-171	36	49	the	the	DET
arestyrurj-171	36	50	autophagosome	autophagosome	NOUN
arestyrurj-171	36	51	will	will	AUX
arestyrurj-171	36	52	move	move	VERB
arestyrurj-171	36	53	toward	toward	ADP
arestyrurj-171	36	54	the	the	DET
arestyrurj-171	36	55	lysosome	lysosome	NOUN
arestyrurj-171	36	56	via	via	ADP
arestyrurj-171	36	57	the	the	DET
arestyrurj-171	36	58	cell	cell	NOUN
arestyrurj-171	36	59	’s	’s	PART
arestyrurj-171	36	60	microtubules.[17	microtubules.[17	PROPN
arestyrurj-171	36	61	]	]	PUNCT
arestyrurj-171	36	62	once	once	ADV
arestyrurj-171	36	63	at	at	ADP
arestyrurj-171	36	64	the	the	DET
arestyrurj-171	36	65	lysosome	lysosome	NOUN
arestyrurj-171	36	66	,	,	PUNCT
arestyrurj-171	36	67	the	the	DET
arestyrurj-171	36	68	autophagosome	autophagosome	NOUN
arestyrurj-171	36	69	’s	’s	PART
arestyrurj-171	36	70	outer	outer	ADJ
arestyrurj-171	36	71	membrane	membrane	NOUN
arestyrurj-171	36	72	will	will	AUX
arestyrurj-171	36	73	fuse	fuse	VERB
arestyrurj-171	36	74	with	with	ADP
arestyrurj-171	36	75	the	the	DET
arestyrurj-171	36	76	lysosomal	lysosomal	ADJ
arestyrurj-171	36	77	membrane	membrane	NOUN
arestyrurj-171	36	78	,	,	PUNCT
arestyrurj-171	36	79	creating	create	VERB
arestyrurj-171	36	80	an	an	DET
arestyrurj-171	36	81	autolysosome	autolysosome	NOUN
arestyrurj-171	36	82	.	.	PUNCT
arestyrurj-171	37	1	the	the	DET
arestyrurj-171	37	2	autophagosome	autophagosome	NOUN
arestyrurj-171	37	3	may	may	AUX
arestyrurj-171	37	4	also	also	ADV
arestyrurj-171	37	5	fuse	fuse	VERB
arestyrurj-171	37	6	with	with	ADP
arestyrurj-171	37	7	endosomes	endosome	NOUN
arestyrurj-171	37	8	,	,	PUNCT
arestyrurj-171	37	9	in	in	ADP
arestyrurj-171	37	10	both	both	CCONJ
arestyrurj-171	37	11	early	early	ADJ
arestyrurj-171	37	12	and	and	CCONJ
arestyrurj-171	37	13	late	late	ADJ
arestyrurj-171	37	14	stages	stage	NOUN
arestyrurj-171	37	15	,	,	PUNCT
arestyrurj-171	37	16	before	before	ADP
arestyrurj-171	37	17	fusing	fuse	VERB
arestyrurj-171	37	18	with	with	ADP
arestyrurj-171	37	19	the	the	DET
arestyrurj-171	37	20	lysosome.[2,25	lysosome.[2,25	NOUN
arestyrurj-171	37	21	]	]	X
arestyrurj-171	37	22	the	the	DET
arestyrurj-171	37	23	last	last	ADJ
arestyrurj-171	37	24	step	step	NOUN
arestyrurj-171	37	25	of	of	ADP
arestyrurj-171	37	26	autophagy	autophagy	NOUN
arestyrurj-171	37	27	is	be	AUX
arestyrurj-171	37	28	referred	refer	VERB
arestyrurj-171	37	29	to	to	ADP
arestyrurj-171	37	30	as	as	ADP
arestyrurj-171	37	31	autophagic	autophagic	NOUN
arestyrurj-171	37	32	flux	flux	NOUN
arestyrurj-171	37	33	where	where	SCONJ
arestyrurj-171	37	34	degradation	degradation	NOUN
arestyrurj-171	37	35	within	within	ADP
arestyrurj-171	37	36	the	the	DET
arestyrurj-171	37	37	autolysosome	autolysosome	NOUN
arestyrurj-171	37	38	begins	begin	VERB
arestyrurj-171	37	39	when	when	SCONJ
arestyrurj-171	37	40	the	the	DET
arestyrurj-171	37	41	inner	inner	ADJ
arestyrurj-171	37	42	membrane	membrane	NOUN
arestyrurj-171	37	43	is	be	AUX
arestyrurj-171	37	44	disrupted	disrupt	VERB
arestyrurj-171	37	45	by	by	ADP
arestyrurj-171	37	46	atg15.[7,24	atg15.[7,24	PROPN
arestyrurj-171	37	47	]	]	PUNCT
arestyrurj-171	37	48	once	once	SCONJ
arestyrurj-171	37	49	the	the	DET
arestyrurj-171	37	50	inner	inner	ADJ
arestyrurj-171	37	51	membrane	membrane	NOUN
arestyrurj-171	37	52	is	be	AUX
arestyrurj-171	37	53	disrupted	disrupt	VERB
arestyrurj-171	37	54	,	,	PUNCT
arestyrurj-171	37	55	the	the	DET
arestyrurj-171	37	56	cargo	cargo	NOUN
arestyrurj-171	37	57	that	that	PRON
arestyrurj-171	37	58	the	the	DET
arestyrurj-171	37	59	autophagosome	autophagosome	NOUN
arestyrurj-171	37	60	carried	carry	VERB
arestyrurj-171	37	61	is	be	AUX
arestyrurj-171	37	62	exposed	expose	VERB
arestyrurj-171	37	63	to	to	ADP
arestyrurj-171	37	64	the	the	DET
arestyrurj-171	37	65	lysosome	lysosome	NOUN
arestyrurj-171	37	66	’s	’s	PART
arestyrurj-171	37	67	acidic	acidic	ADJ
arestyrurj-171	37	68	environment	environment	NOUN
arestyrurj-171	37	69	and	and	CCONJ
arestyrurj-171	37	70	hydrolases	hydrolase	NOUN
arestyrurj-171	37	71	that	that	PRON
arestyrurj-171	37	72	degrade	degrade	VERB
arestyrurj-171	37	73	molecules	molecule	NOUN
arestyrurj-171	37	74	into	into	ADP
arestyrurj-171	37	75	their	their	PRON
arestyrurj-171	37	76	basic	basic	ADJ
arestyrurj-171	37	77	monomers	monomer	NOUN
arestyrurj-171	37	78	.	.	PUNCT
arestyrurj-171	38	1	these	these	DET
arestyrurj-171	38	2	metabolites	metabolite	NOUN
arestyrurj-171	38	3	are	be	AUX
arestyrurj-171	38	4	then	then	ADV
arestyrurj-171	38	5	exported	export	VERB
arestyrurj-171	38	6	from	from	ADP
arestyrurj-171	38	7	the	the	DET
arestyrurj-171	38	8	lysosome	lysosome	NOUN
arestyrurj-171	38	9	into	into	ADP
arestyrurj-171	38	10	the	the	DET
arestyrurj-171	38	11	cell	cell	NOUN
arestyrurj-171	38	12	via	via	ADP
arestyrurj-171	38	13	transporter	transporter	NOUN
arestyrurj-171	38	14	proteins	protein	NOUN
arestyrurj-171	38	15	on	on	ADP
arestyrurj-171	38	16	the	the	DET
arestyrurj-171	38	17	lysosomal	lysosomal	ADJ
arestyrurj-171	38	18	membrane.[29	membrane.[29	NOUN
arestyrurj-171	38	19	]	]	X
arestyrurj-171	38	20	different	different	ADJ
arestyrurj-171	38	21	metabolites	metabolite	NOUN
arestyrurj-171	38	22	are	be	AUX
arestyrurj-171	38	23	transported	transport	VERB
arestyrurj-171	38	24	out	out	ADP
arestyrurj-171	38	25	by	by	ADP
arestyrurj-171	38	26	different	different	ADJ
arestyrurj-171	38	27	receptors	receptor	NOUN
arestyrurj-171	38	28	.	.	PUNCT
arestyrurj-171	39	1	npc-1	npc-1	NOUN
arestyrurj-171	39	2	and	and	CCONJ
arestyrurj-171	39	3	npc-2	npc-2	PRON
arestyrurj-171	39	4	proteins	protein	NOUN
arestyrurj-171	39	5	are	be	AUX
arestyrurj-171	39	6	examples	example	NOUN
arestyrurj-171	39	7	of	of	ADP
arestyrurj-171	39	8	these	these	DET
arestyrurj-171	39	9	receptors	receptor	NOUN
arestyrurj-171	39	10	used	use	VERB
arestyrurj-171	39	11	in	in	ADP
arestyrurj-171	39	12	the	the	DET
arestyrurj-171	39	13	transport	transport	NOUN
arestyrurj-171	39	14	of	of	ADP
arestyrurj-171	39	15	cholesterol	cholesterol	NOUN
arestyrurj-171	39	16	out	out	ADP
arestyrurj-171	39	17	of	of	ADP
arestyrurj-171	39	18	the	the	DET
arestyrurj-171	39	19	lysosome.[20,27	lysosome.[20,27	ADJ
arestyrurj-171	39	20	]	]	PUNCT
arestyrurj-171	39	21	niemann	niemann	PROPN
arestyrurj-171	39	22	pick	pick	PROPN
arestyrurj-171	39	23	c	c	PROPN
arestyrurj-171	39	24	(	(	PUNCT
arestyrurj-171	39	25	npc	npc	NOUN
arestyrurj-171	39	26	)	)	PUNCT
arestyrurj-171	39	27	disease	disease	NOUN
arestyrurj-171	39	28	is	be	AUX
arestyrurj-171	39	29	a	a	DET
arestyrurj-171	39	30	type	type	NOUN
arestyrurj-171	39	31	of	of	ADP
arestyrurj-171	39	32	lysosomal	lysosomal	ADJ
arestyrurj-171	39	33	storage	storage	NOUN
arestyrurj-171	39	34	disorder	disorder	NOUN
arestyrurj-171	39	35	,	,	PUNCT
arestyrurj-171	39	36	which	which	PRON
arestyrurj-171	39	37	is	be	AUX
arestyrurj-171	39	38	a	a	DET
arestyrurj-171	39	39	category	category	NOUN
arestyrurj-171	39	40	of	of	ADP
arestyrurj-171	39	41	disorders	disorder	NOUN
arestyrurj-171	39	42	usually	usually	ADV
arestyrurj-171	39	43	caused	cause	VERB
arestyrurj-171	39	44	by	by	ADP
arestyrurj-171	39	45	a	a	DET
arestyrurj-171	39	46	mutation	mutation	NOUN
arestyrurj-171	39	47	in	in	ADP
arestyrurj-171	39	48	a	a	DET
arestyrurj-171	39	49	gene	gene	NOUN
arestyrurj-171	39	50	that	that	PRON
arestyrurj-171	39	51	codes	code	VERB
arestyrurj-171	39	52	for	for	ADP
arestyrurj-171	39	53	a	a	DET
arestyrurj-171	39	54	lysosomal	lysosomal	ADJ
arestyrurj-171	39	55	transport	transport	NOUN
arestyrurj-171	39	56	protein.[21	protein.[21	PROPN
arestyrurj-171	39	57	]	]	PUNCT
arestyrurj-171	39	58	several	several	ADJ
arestyrurj-171	39	59	studies	study	NOUN
arestyrurj-171	39	60	have	have	AUX
arestyrurj-171	39	61	shown	show	VERB
arestyrurj-171	39	62	that	that	SCONJ
arestyrurj-171	39	63	autophagy	autophagy	NOUN
arestyrurj-171	39	64	is	be	AUX
arestyrurj-171	39	65	blocked	block	VERB
arestyrurj-171	39	66	or	or	CCONJ
arestyrurj-171	39	67	dysfunctional	dysfunctional	ADJ
arestyrurj-171	39	68	in	in	ADP
arestyrurj-171	39	69	most	most	ADJ
arestyrurj-171	39	70	lysosomal	lysosomal	ADJ
arestyrurj-171	39	71	storage	storage	NOUN
arestyrurj-171	39	72	disorders	disorder	NOUN
arestyrurj-171	39	73	because	because	SCONJ
arestyrurj-171	39	74	of	of	ADP
arestyrurj-171	39	75	impaired	impaired	ADJ
arestyrurj-171	39	76	fusion	fusion	NOUN
arestyrurj-171	39	77	between	between	ADP
arestyrurj-171	39	78	the	the	DET
arestyrurj-171	39	79	autophagosome	autophagosome	NOUN
arestyrurj-171	39	80	and	and	CCONJ
arestyrurj-171	39	81	the	the	DET
arestyrurj-171	39	82	lysosome.[13,22,23	lysosome.[13,22,23	PROPN
arestyrurj-171	39	83	]	]	PUNCT
arestyrurj-171	39	84	this	this	DET
arestyrurj-171	39	85	block	block	NOUN
arestyrurj-171	39	86	is	be	AUX
arestyrurj-171	39	87	thought	think	VERB
arestyrurj-171	39	88	to	to	PART
arestyrurj-171	39	89	be	be	AUX
arestyrurj-171	39	90	caused	cause	VERB
arestyrurj-171	39	91	by	by	ADP
arestyrurj-171	39	92	abnormal	abnormal	ADJ
arestyrurj-171	39	93	cholesterol	cholesterol	NOUN
arestyrurj-171	39	94	accumulation	accumulation	NOUN
arestyrurj-171	39	95	in	in	ADP
arestyrurj-171	39	96	the	the	DET
arestyrurj-171	39	97	lysosome.[1	lysosome.[1	NOUN
arestyrurj-171	39	98	]	]	PUNCT
arestyrurj-171	39	99	therefore	therefore	ADV
arestyrurj-171	39	100	,	,	PUNCT
arestyrurj-171	39	101	in	in	ADP
arestyrurj-171	39	102	npc	npc	NOUN
arestyrurj-171	39	103	disease	disease	NOUN
arestyrurj-171	39	104	,	,	PUNCT
arestyrurj-171	39	105	since	since	SCONJ
arestyrurj-171	39	106	one	one	NUM
arestyrurj-171	39	107	of	of	ADP
arestyrurj-171	39	108	the	the	DET
arestyrurj-171	39	109	npc	npc	NOUN
arestyrurj-171	39	110	proteins	protein	NOUN
arestyrurj-171	39	111	is	be	AUX
arestyrurj-171	39	112	nonfunctional	nonfunctional	ADJ
arestyrurj-171	39	113	,	,	PUNCT
arestyrurj-171	39	114	cholesterol	cholesterol	NOUN
arestyrurj-171	39	115	will	will	AUX
arestyrurj-171	39	116	be	be	AUX
arestyrurj-171	39	117	trapped	trap	VERB
arestyrurj-171	39	118	in	in	ADP
arestyrurj-171	39	119	the	the	DET
arestyrurj-171	39	120	lysosomes	lysosome	NOUN
arestyrurj-171	39	121	and	and	CCONJ
arestyrurj-171	39	122	autophagy	autophagy	NOUN
arestyrurj-171	39	123	will	will	AUX
arestyrurj-171	39	124	be	be	AUX
arestyrurj-171	39	125	blocked	block	VERB
arestyrurj-171	39	126	due	due	ADP
arestyrurj-171	39	127	to	to	ADP
arestyrurj-171	39	128	an	an	DET
arestyrurj-171	39	129	inability	inability	NOUN
arestyrurj-171	39	130	of	of	ADP
arestyrurj-171	39	131	the	the	DET
arestyrurj-171	39	132	autophagosome	autophagosome	NOUN
arestyrurj-171	39	133	to	to	PART
arestyrurj-171	39	134	fuse	fuse	VERB
arestyrurj-171	39	135	with	with	ADP
arestyrurj-171	39	136	cholesterol	cholesterol	NOUN
arestyrurj-171	39	137	-	-	PUNCT
arestyrurj-171	39	138	filled	fill	VERB
arestyrurj-171	39	139	lysosomes	lysosome	NOUN
arestyrurj-171	39	140	.	.	PUNCT
arestyrurj-171	40	1	it	it	PRON
arestyrurj-171	40	2	was	be	AUX
arestyrurj-171	40	3	found	find	VERB
arestyrurj-171	40	4	that	that	SCONJ
arestyrurj-171	40	5	cholesterol	cholesterol	NOUN
arestyrurj-171	40	6	clearance	clearance	NOUN
arestyrurj-171	40	7	depends	depend	VERB
arestyrurj-171	40	8	on	on	ADP
arestyrurj-171	40	9	the	the	DET
arestyrurj-171	40	10	interaction	interaction	NOUN
arestyrurj-171	40	11	of	of	ADP
arestyrurj-171	40	12	a	a	DET
arestyrurj-171	40	13	region	region	NOUN
arestyrurj-171	40	14	of	of	ADP
arestyrurj-171	40	15	the	the	DET
arestyrurj-171	40	16	npc-2	npc-2	ADJ
arestyrurj-171	40	17	protein	protein	NOUN
arestyrurj-171	40	18	with	with	ADP
arestyrurj-171	40	19	a	a	DET
arestyrurj-171	40	20	lipid	lipid	NOUN
arestyrurj-171	40	21	called	call	VERB
arestyrurj-171	40	22	lysobisphosphatidic	lysobisphosphatidic	ADJ
arestyrurj-171	40	23	acid	acid	NOUN
arestyrurj-171	40	24	,	,	PUNCT
arestyrurj-171	40	25	or	or	CCONJ
arestyrurj-171	40	26	lpba.[6	lpba.[6	NOUN
arestyrurj-171	40	27	]	]	X
arestyrurj-171	40	28	in	in	ADP
arestyrurj-171	40	29	patients	patient	NOUN
arestyrurj-171	40	30	with	with	ADP
arestyrurj-171	40	31	npc-1	npc-1	NOUN
arestyrurj-171	40	32	disease	disease	NOUN
arestyrurj-171	40	33	,	,	PUNCT
arestyrurj-171	40	34	meaning	mean	VERB
arestyrurj-171	40	35	their	their	PRON
arestyrurj-171	40	36	npc-1	npc-1	NOUN
arestyrurj-171	40	37	protein	protein	NOUN
arestyrurj-171	40	38	is	be	AUX
arestyrurj-171	40	39	dysfunctional	dysfunctional	ADJ
arestyrurj-171	40	40	,	,	PUNCT
arestyrurj-171	40	41	cholesterol	cholesterol	NOUN
arestyrurj-171	40	42	clearance	clearance	NOUN
arestyrurj-171	40	43	is	be	AUX
arestyrurj-171	40	44	still	still	ADV
arestyrurj-171	40	45	affected	affect	VERB
arestyrurj-171	40	46	.	.	PUNCT
arestyrurj-171	41	1	this	this	PRON
arestyrurj-171	41	2	is	be	AUX
arestyrurj-171	41	3	because	because	SCONJ
arestyrurj-171	41	4	the	the	DET
arestyrurj-171	41	5	limiting	limit	VERB
arestyrurj-171	41	6	membrane	membrane	NOUN
arestyrurj-171	41	7	of	of	ADP
arestyrurj-171	41	8	a	a	DET
arestyrurj-171	41	9	lysosome	lysosome	NOUN
arestyrurj-171	41	10	is	be	AUX
arestyrurj-171	41	11	covered	cover	VERB
arestyrurj-171	41	12	in	in	ADP
arestyrurj-171	41	13	a	a	DET
arestyrurj-171	41	14	sugar	sugar	NOUN
arestyrurj-171	41	15	coat	coat	NOUN
arestyrurj-171	41	16	called	call	VERB
arestyrurj-171	41	17	glycocalyx	glycocalyx	PROPN
arestyrurj-171	41	18	and	and	CCONJ
arestyrurj-171	41	19	it	it	PRON
arestyrurj-171	41	20	is	be	AUX
arestyrurj-171	41	21	believed	believe	VERB
arestyrurj-171	41	22	that	that	SCONJ
arestyrurj-171	41	23	the	the	DET
arestyrurj-171	41	24	luminal	luminal	ADJ
arestyrurj-171	41	25	domains	domain	NOUN
arestyrurj-171	41	26	of	of	ADP
arestyrurj-171	41	27	the	the	DET
arestyrurj-171	41	28	npc-1	npc-1	NOUN
arestyrurj-171	41	29	protein	protein	NOUN
arestyrurj-171	41	30	are	be	AUX
arestyrurj-171	41	31	required	require	VERB
arestyrurj-171	41	32	for	for	SCONJ
arestyrurj-171	41	33	cholesterol	cholesterol	NOUN
arestyrurj-171	41	34	to	to	PART
arestyrurj-171	41	35	be	be	AUX
arestyrurj-171	41	36	able	able	ADJ
arestyrurj-171	41	37	to	to	PART
arestyrurj-171	41	38	penetrate	penetrate	VERB
arestyrurj-171	41	39	through	through	ADP
arestyrurj-171	41	40	the	the	DET
arestyrurj-171	41	41	glycocalyx	glycocalyx	NOUN
arestyrurj-171	41	42	and	and	CCONJ
arestyrurj-171	41	43	exit	exit	VERB
arestyrurj-171	41	44	the	the	DET
arestyrurj-171	41	45	lysosome.[11,12	lysosome.[11,12	PROPN
arestyrurj-171	41	46	]	]	PUNCT
arestyrurj-171	41	47	increasing	increase	VERB
arestyrurj-171	41	48	the	the	DET
arestyrurj-171	41	49	lbpa	lbpa	NOUN
arestyrurj-171	41	50	levels	level	NOUN
arestyrurj-171	41	51	in	in	ADP
arestyrurj-171	41	52	npc-1	npc-1	VERB
arestyrurj-171	41	53	deficient	deficient	ADJ
arestyrurj-171	41	54	cells	cell	NOUN
arestyrurj-171	41	55	have	have	AUX
arestyrurj-171	41	56	been	be	AUX
arestyrurj-171	41	57	found	find	VERB
arestyrurj-171	41	58	to	to	PART
arestyrurj-171	41	59	result	result	VERB
arestyrurj-171	41	60	in	in	ADP
arestyrurj-171	41	61	a	a	DET
arestyrurj-171	41	62	significant	significant	ADJ
arestyrurj-171	41	63	amount	amount	NOUN
arestyrurj-171	41	64	of	of	ADP
arestyrurj-171	41	65	cholesterol	cholesterol	NOUN
arestyrurj-171	41	66	clearance	clearance	NOUN
arestyrurj-171	41	67	because	because	SCONJ
arestyrurj-171	41	68	the	the	DET
arestyrurj-171	41	69	lbpa	lbpa	NOUN
arestyrurj-171	41	70	can	can	AUX
arestyrurj-171	41	71	still	still	ADV
arestyrurj-171	41	72	interact	interact	VERB
arestyrurj-171	41	73	with	with	ADP
arestyrurj-171	41	74	the	the	DET
arestyrurj-171	41	75	npc-2	npc-2	ADJ
arestyrurj-171	41	76	protein.[6	protein.[6	NOUN
arestyrurj-171	41	77	]	]	PUNCT
arestyrurj-171	41	78	exogenous	exogenous	ADJ
arestyrurj-171	41	79	treatment	treatment	NOUN
arestyrurj-171	41	80	of	of	ADP
arestyrurj-171	41	81	lbpa	lbpa	NOUN
arestyrurj-171	41	82	’s	’s	PART
arestyrurj-171	41	83	precursor	precursor	NOUN
arestyrurj-171	41	84	phosphatidylglycerol	phosphatidylglycerol	NOUN
arestyrurj-171	41	85	,	,	PUNCT
arestyrurj-171	41	86	or	or	CCONJ
arestyrurj-171	41	87	pg	pg	INTJ
arestyrurj-171	41	88	,	,	PUNCT
arestyrurj-171	41	89	also	also	ADV
arestyrurj-171	41	90	results	result	VERB
arestyrurj-171	41	91	in	in	ADP
arestyrurj-171	41	92	cholesterol	cholesterol	NOUN
arestyrurj-171	41	93	clearance	clearance	NOUN
arestyrurj-171	41	94	because	because	SCONJ
arestyrurj-171	41	95	the	the	DET
arestyrurj-171	41	96	pg	pg	NOUN
arestyrurj-171	41	97	can	can	AUX
arestyrurj-171	41	98	go	go	VERB
arestyrurj-171	41	99	through	through	ADP
arestyrurj-171	41	100	its	its	PRON
arestyrurj-171	41	101	biosynthetic	biosynthetic	ADJ
arestyrurj-171	41	102	pathway	pathway	NOUN
arestyrurj-171	41	103	to	to	PART
arestyrurj-171	41	104	make	make	VERB
arestyrurj-171	41	105	lbpa.[13	lbpa.[13	PROPN
arestyrurj-171	41	106	]	]	X
arestyrurj-171	41	107	our	our	PRON
arestyrurj-171	41	108	preliminary	preliminary	ADJ
arestyrurj-171	41	109	data	datum	NOUN
arestyrurj-171	41	110	shows	show	VERB
arestyrurj-171	41	111	that	that	SCONJ
arestyrurj-171	41	112	pg	pg	VERB
arestyrurj-171	41	113	treatment	treatment	NOUN
arestyrurj-171	41	114	of	of	ADP
arestyrurj-171	41	115	npc-1	npc-1	NOUN
arestyrurj-171	41	116	deficient	deficient	ADJ
arestyrurj-171	41	117	cells	cell	NOUN
arestyrurj-171	41	118	facilitates	facilitates	AUX
arestyrurj-171	41	119	autophagosome	autophagosome	VERB
arestyrurj-171	41	120	fusion	fusion	NOUN
arestyrurj-171	41	121	with	with	ADP
arestyrurj-171	41	122	the	the	DET
arestyrurj-171	41	123	lysosome	lysosome	NOUN
arestyrurj-171	41	124	and	and	CCONJ
arestyrurj-171	41	125	subsequent	subsequent	ADJ
arestyrurj-171	41	126	autophagic	autophagic	PROPN
arestyrurj-171	41	127	flux	flux	NOUN
arestyrurj-171	41	128	.	.	PUNCT
arestyrurj-171	42	1	since	since	SCONJ
arestyrurj-171	42	2	npc-1	npc-1	VERB
arestyrurj-171	42	3	deficient	deficient	ADJ
arestyrurj-171	42	4	cells	cell	NOUN
arestyrurj-171	42	5	block	block	VERB
arestyrurj-171	42	6	autophagy	autophagy	ADV
arestyrurj-171	42	7	and	and	CCONJ
arestyrurj-171	42	8	pg	pg	PRON
arestyrurj-171	42	9	helps	help	VERB
arestyrurj-171	42	10	it	it	PRON
arestyrurj-171	42	11	resume	resume	VERB
arestyrurj-171	42	12	,	,	PUNCT
arestyrurj-171	42	13	we	we	PRON
arestyrurj-171	42	14	are	be	AUX
arestyrurj-171	42	15	interested	interested	ADJ
arestyrurj-171	42	16	in	in	ADP
arestyrurj-171	42	17	seeing	see	VERB
arestyrurj-171	42	18	if	if	SCONJ
arestyrurj-171	42	19	autolysosome	autolysosome	NOUN
arestyrurj-171	42	20	formation	formation	NOUN
arestyrurj-171	42	21	and	and	CCONJ
arestyrurj-171	42	22	autophagic	autophagic	ADJ
arestyrurj-171	42	23	flux	flux	NOUN
arestyrurj-171	42	24	are	be	AUX
arestyrurj-171	42	25	involved	involve	VERB
arestyrurj-171	42	26	in	in	ADP
arestyrurj-171	42	27	cholesterol	cholesterol	NOUN
arestyrurj-171	42	28	clearance	clearance	NOUN
arestyrurj-171	42	29	from	from	ADP
arestyrurj-171	42	30	late	late	ADJ
arestyrurj-171	42	31	endosomes	endosome	NOUN
arestyrurj-171	42	32	when	when	SCONJ
arestyrurj-171	42	33	these	these	DET
arestyrurj-171	42	34	cells	cell	NOUN
arestyrurj-171	42	35	are	be	AUX
arestyrurj-171	42	36	treated	treat	VERB
arestyrurj-171	42	37	with	with	ADP
arestyrurj-171	42	38	pg	pg	PRON
arestyrurj-171	42	39	.	.	PUNCT
arestyrurj-171	43	1	to	to	PART
arestyrurj-171	43	2	determine	determine	VERB
arestyrurj-171	43	3	whether	whether	SCONJ
arestyrurj-171	43	4	pg	pg	PROPN
arestyrurj-171	43	5	/	/	SYM
arestyrurj-171	43	6	lbpa	lbpa	ADV
arestyrurj-171	43	7	-	-	PUNCT
arestyrurj-171	43	8	induced	induce	VERB
arestyrurj-171	43	9	autophagic	autophagic	ADJ
arestyrurj-171	43	10	flux	flux	NOUN
arestyrurj-171	43	11	and	and	CCONJ
arestyrurj-171	43	12	cholesterol	cholesterol	NOUN
arestyrurj-171	43	13	clearance	clearance	NOUN
arestyrurj-171	43	14	are	be	AUX
arestyrurj-171	43	15	directly	directly	ADV
arestyrurj-171	43	16	linked	link	VERB
arestyrurj-171	43	17	,	,	PUNCT
arestyrurj-171	43	18	we	we	PRON
arestyrurj-171	43	19	blocked	block	VERB
arestyrurj-171	43	20	autophagy	autophagy	ADV
arestyrurj-171	43	21	by	by	ADP
arestyrurj-171	43	22	silencing	silence	VERB
arestyrurj-171	43	23	the	the	DET
arestyrurj-171	43	24	gene	gene	NOUN
arestyrurj-171	43	25	that	that	PRON
arestyrurj-171	43	26	codes	code	VERB
arestyrurj-171	43	27	for	for	ADP
arestyrurj-171	43	28	the	the	DET
arestyrurj-171	43	29	atg12	atg12	ADJ
arestyrurj-171	43	30	protein	protein	NOUN
arestyrurj-171	43	31	.	.	PUNCT
arestyrurj-171	44	1	atg12	atg12	PROPN
arestyrurj-171	44	2	is	be	AUX
arestyrurj-171	44	3	essential	essential	ADJ
arestyrurj-171	44	4	to	to	ADP
arestyrurj-171	44	5	autophagy	autophagy	NOUN
arestyrurj-171	44	6	because	because	SCONJ
arestyrurj-171	44	7	it	it	PRON
arestyrurj-171	44	8	is	be	AUX
arestyrurj-171	44	9	part	part	NOUN
arestyrurj-171	44	10	of	of	ADP
arestyrurj-171	44	11	the	the	DET
arestyrurj-171	44	12	atg12	atg12	PROPN
arestyrurj-171	44	13	-	-	PUNCT
arestyrurj-171	44	14	atg5	atg5	NOUN
arestyrurj-171	44	15	-	-	PUNCT
arestyrurj-171	44	16	atg16l1	atg16l1	PROPN
arestyrurj-171	44	17	complex	complex	NOUN
arestyrurj-171	44	18	that	that	PRON
arestyrurj-171	44	19	binds	bind	VERB
arestyrurj-171	44	20	atg8	atg8	PROPN
arestyrurj-171	44	21	/	/	SYM
arestyrurj-171	44	22	lc3	lc3	NOUN
arestyrurj-171	44	23	to	to	ADP
arestyrurj-171	44	24	the	the	DET
arestyrurj-171	44	25	membrane	membrane	NOUN
arestyrurj-171	44	26	,	,	PUNCT
arestyrurj-171	44	27	an	an	DET
arestyrurj-171	44	28	essential	essential	ADJ
arestyrurj-171	44	29	process	process	NOUN
arestyrurj-171	44	30	in	in	ADP
arestyrurj-171	44	31	phagophore	phagophore	ADJ
arestyrurj-171	44	32	elongation	elongation	NOUN
arestyrurj-171	44	33	.	.	PUNCT
arestyrurj-171	45	1	autophagy	autophagy	NOUN
arestyrurj-171	45	2	can	can	AUX
arestyrurj-171	45	3	be	be	AUX
arestyrurj-171	45	4	blocked	block	VERB
arestyrurj-171	45	5	by	by	ADP
arestyrurj-171	45	6	silencing	silence	VERB
arestyrurj-171	45	7	the	the	DET
arestyrurj-171	45	8	genes	gene	NOUN
arestyrurj-171	45	9	of	of	ADP
arestyrurj-171	45	10	a	a	DET
arestyrurj-171	45	11	number	number	NOUN
arestyrurj-171	45	12	of	of	ADP
arestyrurj-171	45	13	essential	essential	ADJ
arestyrurj-171	45	14	proteins	protein	NOUN
arestyrurj-171	45	15	to	to	ADP
arestyrurj-171	45	16	the	the	DET
arestyrurj-171	45	17	process	process	NOUN
arestyrurj-171	45	18	,	,	PUNCT
arestyrurj-171	45	19	but	but	CCONJ
arestyrurj-171	45	20	we	we	PRON
arestyrurj-171	45	21	will	will	AUX
arestyrurj-171	45	22	only	only	ADV
arestyrurj-171	45	23	focus	focus	VERB
arestyrurj-171	45	24	on	on	ADP
arestyrurj-171	45	25	the	the	DET
arestyrurj-171	45	26	gene	gene	NOUN
arestyrurj-171	45	27	that	that	PRON
arestyrurj-171	45	28	codes	code	VERB
arestyrurj-171	45	29	for	for	ADP
arestyrurj-171	45	30	atg12	atg12	NOUN
arestyrurj-171	45	31	.	.	PUNCT
arestyrurj-171	46	1	after	after	ADP
arestyrurj-171	46	2	making	make	VERB
arestyrurj-171	46	3	the	the	DET
arestyrurj-171	46	4	autophagy	autophagy	ADJ
arestyrurj-171	46	5	knockdown	knockdown	NOUN
arestyrurj-171	46	6	cell	cell	NOUN
arestyrurj-171	46	7	line	line	NOUN
arestyrurj-171	46	8	and	and	CCONJ
arestyrurj-171	46	9	the	the	DET
arestyrurj-171	46	10	control	control	NOUN
arestyrurj-171	46	11	cell	cell	NOUN
arestyrurj-171	46	12	line	line	NOUN
arestyrurj-171	46	13	,	,	PUNCT
arestyrurj-171	46	14	we	we	PRON
arestyrurj-171	46	15	treated	treat	VERB
arestyrurj-171	46	16	the	the	DET
arestyrurj-171	46	17	cells	cell	NOUN
arestyrurj-171	46	18	with	with	ADP
arestyrurj-171	46	19	pg	pg	PROPN
arestyrurj-171	46	20	and	and	CCONJ
arestyrurj-171	46	21	measured	measure	VERB
arestyrurj-171	46	22	the	the	DET
arestyrurj-171	46	23	subsequent	subsequent	ADJ
arestyrurj-171	46	24	cholesterol	cholesterol	NOUN
arestyrurj-171	46	25	accumulation	accumulation	NOUN
arestyrurj-171	46	26	to	to	PART
arestyrurj-171	46	27	see	see	VERB
arestyrurj-171	46	28	if	if	SCONJ
arestyrurj-171	46	29	the	the	DET
arestyrurj-171	46	30	cells	cell	NOUN
arestyrurj-171	46	31	with	with	ADP
arestyrurj-171	46	32	blocked	block	VERB
arestyrurj-171	46	33	autophagy	autophagy	NOUN
arestyrurj-171	46	34	still	still	ADV
arestyrurj-171	46	35	cleared	clear	VERB
arestyrurj-171	46	36	cholesterol	cholesterol	NOUN
arestyrurj-171	46	37	to	to	ADP
arestyrurj-171	46	38	the	the	DET
arestyrurj-171	46	39	same	same	ADJ
arestyrurj-171	46	40	extent	extent	NOUN
arestyrurj-171	46	41	.	.	PUNCT
arestyrurj-171	47	1	if	if	SCONJ
arestyrurj-171	47	2	autophagy	autophagy	NOUN
arestyrurj-171	47	3	is	be	AUX
arestyrurj-171	47	4	involved	involve	VERB
arestyrurj-171	47	5	in	in	ADP
arestyrurj-171	47	6	cholesterol	cholesterol	NOUN
arestyrurj-171	47	7	clearance	clearance	NOUN
arestyrurj-171	47	8	during	during	ADP
arestyrurj-171	47	9	pg	pg	PROPN
arestyrurj-171	47	10	treatment	treatment	NOUN
arestyrurj-171	47	11	,	,	PUNCT
arestyrurj-171	47	12	the	the	DET
arestyrurj-171	47	13	cells	cell	NOUN
arestyrurj-171	47	14	that	that	PRON
arestyrurj-171	47	15	received	receive	VERB
arestyrurj-171	47	16	the	the	DET
arestyrurj-171	47	17	pg	pg	NOUN
arestyrurj-171	47	18	treatment	treatment	NOUN
arestyrurj-171	47	19	but	but	CCONJ
arestyrurj-171	47	20	had	have	AUX
arestyrurj-171	47	21	autophagy	autophagy	VERB
arestyrurj-171	47	22	blocked	block	VERB
arestyrurj-171	47	23	would	would	AUX
arestyrurj-171	47	24	have	have	VERB
arestyrurj-171	47	25	less	less	ADJ
arestyrurj-171	47	26	cholesterol	cholesterol	NOUN
arestyrurj-171	47	27	clearance	clearance	NOUN
arestyrurj-171	47	28	than	than	ADP
arestyrurj-171	47	29	cells	cell	NOUN
arestyrurj-171	47	30	that	that	PRON
arestyrurj-171	47	31	received	receive	VERB
arestyrurj-171	47	32	the	the	DET
arestyrurj-171	47	33	pg	pg	NOUN
arestyrurj-171	47	34	treatment	treatment	NOUN
arestyrurj-171	47	35	and	and	CCONJ
arestyrurj-171	47	36	had	have	VERB
arestyrurj-171	47	37	functional	functional	ADJ
arestyrurj-171	47	38	autophagy	autophagy	NOUN
arestyrurj-171	47	39	.	.	PUNCT
arestyrurj-171	48	1	2	2	NUM
arestyrurj-171	48	2	methodology	methodology	NOUN
arestyrurj-171	48	3	npc-1	npc-1	NOUN
arestyrurj-171	48	4	deficient	deficient	ADJ
arestyrurj-171	48	5	cells	cell	NOUN
arestyrurj-171	48	6	were	be	AUX
arestyrurj-171	48	7	seeded	seed	VERB
arestyrurj-171	48	8	in	in	ADP
arestyrurj-171	48	9	12	12	NUM
arestyrurj-171	48	10	-	-	PUNCT
arestyrurj-171	48	11	well	well	NOUN
arestyrurj-171	48	12	plates	plate	NOUN
arestyrurj-171	48	13	on	on	ADP
arestyrurj-171	48	14	coverslips	coverslip	NOUN
arestyrurj-171	48	15	with	with	ADP
arestyrurj-171	48	16	antibiotic	antibiotic	ADJ
arestyrurj-171	48	17	-	-	PUNCT
arestyrurj-171	48	18	free	free	ADJ
arestyrurj-171	48	19	growth	growth	NOUN
arestyrurj-171	48	20	medium	medium	NOUN
arestyrurj-171	48	21	supplemented	supplement	VERB
arestyrurj-171	48	22	with	with	ADP
arestyrurj-171	48	23	fbs	fbs	PROPN
arestyrurj-171	48	24	(	(	PUNCT
arestyrurj-171	48	25	fetal	fetal	ADJ
arestyrurj-171	48	26	bovine	bovine	NOUN
arestyrurj-171	48	27	serum	serum	NOUN
arestyrurj-171	48	28	)	)	PUNCT
arestyrurj-171	48	29	,	,	PUNCT
arestyrurj-171	48	30	which	which	PRON
arestyrurj-171	48	31	contains	contain	VERB
arestyrurj-171	48	32	nutrients	nutrient	NOUN
arestyrurj-171	48	33	that	that	PRON
arestyrurj-171	48	34	help	help	VERB
arestyrurj-171	48	35	the	the	DET
arestyrurj-171	48	36	cells	cell	NOUN
arestyrurj-171	48	37	grow	grow	VERB
arestyrurj-171	48	38	and	and	CCONJ
arestyrurj-171	48	39	divide	divide	VERB
arestyrurj-171	48	40	.	.	PUNCT
arestyrurj-171	49	1	the	the	DET
arestyrurj-171	49	2	cells	cell	NOUN
arestyrurj-171	49	3	were	be	AUX
arestyrurj-171	49	4	npc-1	npc-1	NUM
arestyrurj-171	49	5	deficient	deficient	ADJ
arestyrurj-171	49	6	either	either	CCONJ
arestyrurj-171	49	7	be	be	AUX
arestyrurj-171	49	8	aresty	aresty	ADJ
arestyrurj-171	49	9	rutgers	rutgers	PROPN
arestyrurj-171	49	10	undergraduate	undergraduate	PROPN
arestyrurj-171	49	11	research	research	PROPN
arestyrurj-171	49	12	journal	journal	PROPN
arestyrurj-171	49	13	,	,	PUNCT
arestyrurj-171	49	14	volume	volume	NOUN
arestyrurj-171	49	15	i	i	PRON
arestyrurj-171	49	16	,	,	PUNCT
arestyrurj-171	50	1	issue	issue	NOUN
arestyrurj-171	50	2	iii	iii	NOUN
arestyrurj-171	50	3	cause	cause	SCONJ
arestyrurj-171	50	4	they	they	PRON
arestyrurj-171	50	5	were	be	AUX
arestyrurj-171	50	6	fibroblast	fibroblast	ADJ
arestyrurj-171	50	7	cells	cell	NOUN
arestyrurj-171	50	8	taken	take	VERB
arestyrurj-171	50	9	from	from	ADP
arestyrurj-171	50	10	patients	patient	NOUN
arestyrurj-171	50	11	with	with	ADP
arestyrurj-171	50	12	npc-1	npc-1	NOUN
arestyrurj-171	50	13	disease	disease	NOUN
arestyrurj-171	50	14	or	or	CCONJ
arestyrurj-171	50	15	because	because	SCONJ
arestyrurj-171	50	16	they	they	PRON
arestyrurj-171	50	17	were	be	AUX
arestyrurj-171	50	18	npc-1	npc-1	VERB
arestyrurj-171	50	19	knocked	knock	VERB
arestyrurj-171	50	20	out	out	ADP
arestyrurj-171	50	21	hela	hela	PROPN
arestyrurj-171	50	22	cells	cell	NOUN
arestyrurj-171	50	23	,	,	PUNCT
arestyrurj-171	50	24	meaning	mean	VERB
arestyrurj-171	50	25	the	the	DET
arestyrurj-171	50	26	gene	gene	NOUN
arestyrurj-171	50	27	that	that	PRON
arestyrurj-171	50	28	codes	code	VERB
arestyrurj-171	50	29	for	for	ADP
arestyrurj-171	50	30	the	the	DET
arestyrurj-171	50	31	npc-1	npc-1	NOUN
arestyrurj-171	50	32	protein	protein	NOUN
arestyrurj-171	50	33	was	be	AUX
arestyrurj-171	50	34	silenced	silence	VERB
arestyrurj-171	50	35	.	.	PUNCT
arestyrurj-171	51	1	these	these	DET
arestyrurj-171	51	2	hela	hela	PROPN
arestyrurj-171	51	3	cells	cell	NOUN
arestyrurj-171	51	4	are	be	AUX
arestyrurj-171	51	5	true	true	ADJ
arestyrurj-171	51	6	npc-1	npc-1	VERB
arestyrurj-171	51	7	-/-	-/-	PROPN
arestyrurj-171	51	8	,	,	PUNCT
arestyrurj-171	51	9	meaning	meaning	NOUN
arestyrurj-171	51	10	npc-1	npc-1	NOUN
arestyrurj-171	51	11	will	will	AUX
arestyrurj-171	51	12	be	be	AUX
arestyrurj-171	51	13	100	100	NUM
arestyrurj-171	51	14	%	%	NOUN
arestyrurj-171	51	15	knocked	knock	VERB
arestyrurj-171	51	16	-	-	PUNCT
arestyrurj-171	51	17	out	out	NOUN
arestyrurj-171	51	18	.	.	PUNCT
arestyrurj-171	52	1	after	after	ADP
arestyrurj-171	52	2	24	24	NUM
arestyrurj-171	52	3	hours	hour	NOUN
arestyrurj-171	52	4	,	,	PUNCT
arestyrurj-171	52	5	the	the	DET
arestyrurj-171	52	6	cells	cell	NOUN
arestyrurj-171	52	7	were	be	AUX
arestyrurj-171	52	8	at	at	ADP
arestyrurj-171	52	9	confluency	confluency	NOUN
arestyrurj-171	52	10	,	,	PUNCT
arestyrurj-171	52	11	or	or	CCONJ
arestyrurj-171	52	12	0.5	0.5	NUM
arestyrurj-171	52	13	x	x	SYM
arestyrurj-171	52	14	106	106	NUM
arestyrurj-171	52	15	cells	cell	NOUN
arestyrurj-171	52	16	per	per	ADP
arestyrurj-171	52	17	plate	plate	NOUN
arestyrurj-171	52	18	,	,	PUNCT
arestyrurj-171	52	19	and	and	CCONJ
arestyrurj-171	52	20	we	we	PRON
arestyrurj-171	52	21	washed	wash	VERB
arestyrurj-171	52	22	the	the	DET
arestyrurj-171	52	23	cells	cell	NOUN
arestyrurj-171	52	24	with	with	ADP
arestyrurj-171	52	25	shrna	shrna	ADJ
arestyrurj-171	52	26	transfection	transfection	NOUN
arestyrurj-171	52	27	medium	medium	NOUN
arestyrurj-171	52	28	.	.	PUNCT
arestyrurj-171	53	1	we	we	PRON
arestyrurj-171	53	2	then	then	ADV
arestyrurj-171	53	3	made	make	VERB
arestyrurj-171	53	4	2	2	NUM
arestyrurj-171	53	5	cell	cell	NOUN
arestyrurj-171	53	6	lines	line	NOUN
arestyrurj-171	53	7	:	:	PUNCT
arestyrurj-171	53	8	an	an	DET
arestyrurj-171	53	9	autophagy	autophagy	ADJ
arestyrurj-171	53	10	knockout	knockout	NOUN
arestyrurj-171	53	11	line	line	NOUN
arestyrurj-171	53	12	and	and	CCONJ
arestyrurj-171	53	13	a	a	DET
arestyrurj-171	53	14	control	control	NOUN
arestyrurj-171	53	15	line	line	NOUN
arestyrurj-171	53	16	.	.	PUNCT
arestyrurj-171	54	1	the	the	DET
arestyrurj-171	54	2	cells	cell	NOUN
arestyrurj-171	54	3	for	for	ADP
arestyrurj-171	54	4	the	the	DET
arestyrurj-171	54	5	autophagy	autophagy	ADJ
arestyrurj-171	54	6	knockout	knockout	NOUN
arestyrurj-171	54	7	line	line	NOUN
arestyrurj-171	54	8	were	be	AUX
arestyrurj-171	54	9	transduced	transduce	VERB
arestyrurj-171	54	10	with	with	ADP
arestyrurj-171	54	11	atg12	atg12	PROPN
arestyrurj-171	54	12	shrna	shrna	NOUN
arestyrurj-171	54	13	lentiviral	lentiviral	ADJ
arestyrurj-171	54	14	particles	particle	NOUN
arestyrurj-171	54	15	and	and	CCONJ
arestyrurj-171	54	16	the	the	DET
arestyrurj-171	54	17	cells	cell	NOUN
arestyrurj-171	54	18	for	for	ADP
arestyrurj-171	54	19	the	the	DET
arestyrurj-171	54	20	control	control	NOUN
arestyrurj-171	54	21	line	line	NOUN
arestyrurj-171	54	22	were	be	AUX
arestyrurj-171	54	23	transduced	transduce	VERB
arestyrurj-171	54	24	with	with	ADP
arestyrurj-171	54	25	scrambled	scramble	VERB
arestyrurj-171	54	26	control	control	PROPN
arestyrurj-171	54	27	shrna	shrna	ADJ
arestyrurj-171	54	28	lentiviral	lentiviral	ADJ
arestyrurj-171	54	29	particles	particle	NOUN
arestyrurj-171	54	30	.	.	PUNCT
arestyrurj-171	55	1	the	the	DET
arestyrurj-171	55	2	cells	cell	NOUN
arestyrurj-171	55	3	of	of	ADP
arestyrurj-171	55	4	both	both	DET
arestyrurj-171	55	5	lines	line	NOUN
arestyrurj-171	55	6	were	be	AUX
arestyrurj-171	55	7	transduced	transduce	VERB
arestyrurj-171	55	8	with	with	ADP
arestyrurj-171	55	9	shrna	shrna	ADJ
arestyrurj-171	55	10	lentiviral	lentiviral	ADJ
arestyrurj-171	55	11	particles	particle	NOUN
arestyrurj-171	55	12	in	in	ADP
arestyrurj-171	55	13	concentrations	concentration	NOUN
arestyrurj-171	55	14	of	of	ADP
arestyrurj-171	55	15	1x105	1x105	DET
arestyrurj-171	55	16	infectious	infectious	ADJ
arestyrurj-171	55	17	units	unit	NOUN
arestyrurj-171	55	18	of	of	ADP
arestyrurj-171	55	19	virus	virus	NOUN
arestyrurj-171	55	20	(	(	PUNCT
arestyrurj-171	55	21	ifu	ifu	PROPN
arestyrurj-171	55	22	)	)	PUNCT
arestyrurj-171	55	23	.	.	PUNCT
arestyrurj-171	56	1	the	the	DET
arestyrurj-171	56	2	atg12	atg12	PROPN
arestyrurj-171	56	3	shrna	shrna	NOUN
arestyrurj-171	56	4	encoded	encode	VERB
arestyrurj-171	56	5	for	for	ADP
arestyrurj-171	56	6	a	a	DET
arestyrurj-171	56	7	sequence	sequence	NOUN
arestyrurj-171	56	8	that	that	PRON
arestyrurj-171	56	9	degraded	degrade	VERB
arestyrurj-171	56	10	mrna	mrna	NOUN
arestyrurj-171	56	11	in	in	ADP
arestyrurj-171	56	12	the	the	DET
arestyrurj-171	56	13	cell	cell	NOUN
arestyrurj-171	56	14	that	that	PRON
arestyrurj-171	56	15	coded	code	VERB
arestyrurj-171	56	16	for	for	ADP
arestyrurj-171	56	17	the	the	DET
arestyrurj-171	56	18	atg12	atg12	PROPN
arestyrurj-171	56	19	protein	protein	NOUN
arestyrurj-171	56	20	.	.	PUNCT
arestyrurj-171	57	1	autophagy	autophagy	PROPN
arestyrurj-171	57	2	was	be	AUX
arestyrurj-171	57	3	blocked	block	VERB
arestyrurj-171	57	4	because	because	SCONJ
arestyrurj-171	57	5	these	these	DET
arestyrurj-171	57	6	cells	cell	NOUN
arestyrurj-171	57	7	could	could	AUX
arestyrurj-171	57	8	not	not	PART
arestyrurj-171	57	9	make	make	VERB
arestyrurj-171	57	10	the	the	DET
arestyrurj-171	57	11	atg12	atg12	ADJ
arestyrurj-171	57	12	protein	protein	NOUN
arestyrurj-171	57	13	.	.	PUNCT
arestyrurj-171	58	1	the	the	DET
arestyrurj-171	58	2	scrambled	scramble	VERB
arestyrurj-171	58	3	control	control	PROPN
arestyrurj-171	58	4	shrna	shrna	NOUN
arestyrurj-171	58	5	encoded	encode	VERB
arestyrurj-171	58	6	for	for	ADP
arestyrurj-171	58	7	a	a	DET
arestyrurj-171	58	8	sequence	sequence	NOUN
arestyrurj-171	58	9	that	that	PRON
arestyrurj-171	58	10	did	do	AUX
arestyrurj-171	58	11	not	not	PART
arestyrurj-171	58	12	degrade	degrade	VERB
arestyrurj-171	58	13	any	any	DET
arestyrurj-171	58	14	known	know	VERB
arestyrurj-171	58	15	cellular	cellular	ADJ
arestyrurj-171	58	16	mrna	mrna	NOUN
arestyrurj-171	58	17	.	.	PUNCT
arestyrurj-171	59	1	since	since	SCONJ
arestyrurj-171	59	2	these	these	DET
arestyrurj-171	59	3	cells	cell	NOUN
arestyrurj-171	59	4	could	could	AUX
arestyrurj-171	59	5	express	express	VERB
arestyrurj-171	59	6	all	all	PRON
arestyrurj-171	59	7	of	of	ADP
arestyrurj-171	59	8	their	their	PRON
arestyrurj-171	59	9	normal	normal	ADJ
arestyrurj-171	59	10	proteins	protein	NOUN
arestyrurj-171	59	11	except	except	SCONJ
arestyrurj-171	59	12	npc-1	npc-1	NOUN
arestyrurj-171	59	13	,	,	PUNCT
arestyrurj-171	59	14	autophagy	autophagy	NOUN
arestyrurj-171	59	15	was	be	AUX
arestyrurj-171	59	16	not	not	PART
arestyrurj-171	59	17	blocked	block	VERB
arestyrurj-171	59	18	.	.	PUNCT
arestyrurj-171	60	1	knockdown	knockdown	PROPN
arestyrurj-171	60	2	shrna	shrna	NOUN
arestyrurj-171	60	3	did	do	AUX
arestyrurj-171	60	4	not	not	PART
arestyrurj-171	60	5	get	get	VERB
arestyrurj-171	60	6	rid	rid	VERB
arestyrurj-171	60	7	of	of	ADP
arestyrurj-171	60	8	100	100	NUM
arestyrurj-171	60	9	%	%	NOUN
arestyrurj-171	60	10	of	of	ADP
arestyrurj-171	60	11	the	the	DET
arestyrurj-171	60	12	target	target	NOUN
arestyrurj-171	60	13	mrna	mrna	NOUN
arestyrurj-171	60	14	,	,	PUNCT
arestyrurj-171	60	15	and	and	CCONJ
arestyrurj-171	60	16	preliminary	preliminary	ADJ
arestyrurj-171	60	17	experiments	experiment	NOUN
arestyrurj-171	60	18	showed	show	VERB
arestyrurj-171	60	19	that	that	SCONJ
arestyrurj-171	60	20	autophagy	autophagy	NOUN
arestyrurj-171	60	21	would	would	AUX
arestyrurj-171	60	22	be	be	AUX
arestyrurj-171	60	23	reduced	reduce	VERB
arestyrurj-171	60	24	but	but	CCONJ
arestyrurj-171	60	25	not	not	PART
arestyrurj-171	60	26	completely	completely	ADV
arestyrurj-171	60	27	blocked	block	VERB
arestyrurj-171	60	28	.	.	PUNCT
arestyrurj-171	61	1	after	after	ADP
arestyrurj-171	61	2	48	48	NUM
arestyrurj-171	61	3	hours	hour	NOUN
arestyrurj-171	61	4	of	of	ADP
arestyrurj-171	61	5	incubation	incubation	NOUN
arestyrurj-171	61	6	,	,	PUNCT
arestyrurj-171	61	7	the	the	DET
arestyrurj-171	61	8	old	old	ADJ
arestyrurj-171	61	9	medium	medium	NOUN
arestyrurj-171	61	10	was	be	AUX
arestyrurj-171	61	11	removed	remove	VERB
arestyrurj-171	61	12	and	and	CCONJ
arestyrurj-171	61	13	2	2	NUM
arestyrurj-171	61	14	µg	µg	ADJ
arestyrurj-171	61	15	/	/	SYM
arestyrurj-171	61	16	ml	ml	X
arestyrurj-171	61	17	antibiotic	antibiotic	ADJ
arestyrurj-171	61	18	puromycin	puromycin	PROPN
arestyrurj-171	61	19	medium	medium	NOUN
arestyrurj-171	61	20	was	be	AUX
arestyrurj-171	61	21	added	add	VERB
arestyrurj-171	61	22	to	to	ADP
arestyrurj-171	61	23	all	all	ADV
arestyrurj-171	61	24	well	well	ADV
arestyrurj-171	61	25	.	.	PUNCT
arestyrurj-171	62	1	cells	cell	NOUN
arestyrurj-171	62	2	transfected	transfecte	VERB
arestyrurj-171	62	3	with	with	ADP
arestyrurj-171	62	4	the	the	DET
arestyrurj-171	62	5	virus	virus	NOUN
arestyrurj-171	62	6	particles	particle	NOUN
arestyrurj-171	62	7	would	would	AUX
arestyrurj-171	62	8	have	have	VERB
arestyrurj-171	62	9	a	a	DET
arestyrurj-171	62	10	gene	gene	NOUN
arestyrurj-171	62	11	that	that	PRON
arestyrurj-171	62	12	make	make	VERB
arestyrurj-171	62	13	the	the	DET
arestyrurj-171	62	14	cells	cell	NOUN
arestyrurj-171	62	15	resistant	resistant	ADJ
arestyrurj-171	62	16	to	to	ADP
arestyrurj-171	62	17	puromycin	puromycin	PROPN
arestyrurj-171	62	18	,	,	PUNCT
arestyrurj-171	62	19	while	while	SCONJ
arestyrurj-171	62	20	cells	cell	NOUN
arestyrurj-171	62	21	that	that	PRON
arestyrurj-171	62	22	were	be	AUX
arestyrurj-171	62	23	not	not	PART
arestyrurj-171	62	24	transfected	transfecte	VERB
arestyrurj-171	62	25	would	would	AUX
arestyrurj-171	62	26	be	be	AUX
arestyrurj-171	62	27	killed	kill	VERB
arestyrurj-171	62	28	by	by	ADP
arestyrurj-171	62	29	the	the	DET
arestyrurj-171	62	30	antibiotic	antibiotic	NOUN
arestyrurj-171	62	31	.	.	PUNCT
arestyrurj-171	63	1	cells	cell	NOUN
arestyrurj-171	63	2	were	be	AUX
arestyrurj-171	63	3	then	then	ADV
arestyrurj-171	63	4	incubated	incubate	VERB
arestyrurj-171	63	5	for	for	ADP
arestyrurj-171	63	6	3	3	NUM
arestyrurj-171	63	7	days	day	NOUN
arestyrurj-171	63	8	,	,	PUNCT
arestyrurj-171	63	9	after	after	ADP
arestyrurj-171	63	10	which	which	PRON
arestyrurj-171	63	11	all	all	DET
arestyrurj-171	63	12	stable	stable	ADJ
arestyrurj-171	63	13	cells	cell	NOUN
arestyrurj-171	63	14	that	that	PRON
arestyrurj-171	63	15	remained	remain	VERB
arestyrurj-171	63	16	alive	alive	ADJ
arestyrurj-171	63	17	were	be	AUX
arestyrurj-171	63	18	known	know	VERB
arestyrurj-171	63	19	to	to	PART
arestyrurj-171	63	20	be	be	AUX
arestyrurj-171	63	21	the	the	DET
arestyrurj-171	63	22	ones	one	NOUN
arestyrurj-171	63	23	that	that	PRON
arestyrurj-171	63	24	were	be	AUX
arestyrurj-171	63	25	transfected	transfecte	VERB
arestyrurj-171	63	26	.	.	PUNCT
arestyrurj-171	64	1	each	each	DET
arestyrurj-171	64	2	cell	cell	NOUN
arestyrurj-171	64	3	line	line	NOUN
arestyrurj-171	64	4	had	have	VERB
arestyrurj-171	64	5	a	a	DET
arestyrurj-171	64	6	control	control	NOUN
arestyrurj-171	64	7	group	group	NOUN
arestyrurj-171	64	8	and	and	CCONJ
arestyrurj-171	64	9	a	a	DET
arestyrurj-171	64	10	treatment	treatment	NOUN
arestyrurj-171	64	11	group	group	NOUN
arestyrurj-171	64	12	,	,	PUNCT
arestyrurj-171	64	13	with	with	ADP
arestyrurj-171	64	14	a	a	DET
arestyrurj-171	64	15	total	total	NOUN
arestyrurj-171	64	16	of	of	ADP
arestyrurj-171	64	17	48	48	NUM
arestyrurj-171	64	18	wells	well	NOUN
arestyrurj-171	64	19	.	.	PUNCT
arestyrurj-171	65	1	we	we	PRON
arestyrurj-171	65	2	treated	treat	VERB
arestyrurj-171	65	3	both	both	DET
arestyrurj-171	65	4	treatment	treatment	NOUN
arestyrurj-171	65	5	groups	group	NOUN
arestyrurj-171	65	6	with	with	ADP
arestyrurj-171	65	7	100μm	100μm	PROPN
arestyrurj-171	65	8	pg	pg	PROPN
arestyrurj-171	65	9	and	and	CCONJ
arestyrurj-171	65	10	let	let	VERB
arestyrurj-171	65	11	the	the	DET
arestyrurj-171	65	12	cells	cell	NOUN
arestyrurj-171	65	13	incubate	incubate	VERB
arestyrurj-171	65	14	.	.	PUNCT
arestyrurj-171	66	1	after	after	ADP
arestyrurj-171	66	2	48	48	NUM
arestyrurj-171	66	3	hours	hour	NOUN
arestyrurj-171	66	4	we	we	PRON
arestyrurj-171	66	5	washed	wash	VERB
arestyrurj-171	66	6	all	all	DET
arestyrurj-171	66	7	cells	cell	NOUN
arestyrurj-171	66	8	using	use	VERB
arestyrurj-171	66	9	phosphate	phosphate	NOUN
arestyrurj-171	66	10	buffer	buffer	NOUN
arestyrurj-171	66	11	saline	saline	NOUN
arestyrurj-171	66	12	(	(	PUNCT
arestyrurj-171	66	13	pbs	pbs	PROPN
arestyrurj-171	66	14	)	)	PUNCT
arestyrurj-171	66	15	and	and	CCONJ
arestyrurj-171	66	16	fixed	fix	VERB
arestyrurj-171	66	17	them	they	PRON
arestyrurj-171	66	18	to	to	ADP
arestyrurj-171	66	19	the	the	DET
arestyrurj-171	66	20	coverslips	coverslip	NOUN
arestyrurj-171	66	21	using	use	VERB
arestyrurj-171	66	22	a	a	DET
arestyrurj-171	66	23	4	4	NUM
arestyrurj-171	66	24	%	%	NOUN
arestyrurj-171	66	25	paraformaldehyde	paraformaldehyde	NOUN
arestyrurj-171	66	26	solution	solution	NOUN
arestyrurj-171	66	27	.	.	PUNCT
arestyrurj-171	67	1	we	we	PRON
arestyrurj-171	67	2	then	then	ADV
arestyrurj-171	67	3	stained	stain	VERB
arestyrurj-171	67	4	the	the	DET
arestyrurj-171	67	5	cells	cell	NOUN
arestyrurj-171	67	6	on	on	ADP
arestyrurj-171	67	7	the	the	DET
arestyrurj-171	67	8	coverslips	coverslip	NOUN
arestyrurj-171	67	9	with	with	ADP
arestyrurj-171	67	10	cholesterol	cholesterol	NOUN
arestyrurj-171	67	11	-	-	PUNCT
arestyrurj-171	67	12	binding	bind	VERB
arestyrurj-171	67	13	polyene	polyene	NOUN
arestyrurj-171	67	14	antibiotic	antibiotic	ADJ
arestyrurj-171	67	15	filipin	filipin	NOUN
arestyrurj-171	67	16	iii	iii	PROPN
arestyrurj-171	67	17	and	and	CCONJ
arestyrurj-171	67	18	a	a	DET
arestyrurj-171	67	19	nuclear	nuclear	ADJ
arestyrurj-171	67	20	dye	dye	NOUN
arestyrurj-171	67	21	(	(	PUNCT
arestyrurj-171	67	22	sytox	sytox	NOUN
arestyrurj-171	67	23	green	green	PROPN
arestyrurj-171	67	24	)	)	PUNCT
arestyrurj-171	67	25	.	.	PUNCT
arestyrurj-171	68	1	each	each	PRON
arestyrurj-171	68	2	of	of	ADP
arestyrurj-171	68	3	the	the	DET
arestyrurj-171	68	4	48	48	NUM
arestyrurj-171	68	5	coverslips	coverslip	NOUN
arestyrurj-171	68	6	contained	contain	VERB
arestyrurj-171	68	7	about	about	ADP
arestyrurj-171	68	8	50	50	NUM
arestyrurj-171	68	9	-	-	SYM
arestyrurj-171	68	10	100	100	NUM
arestyrurj-171	68	11	fibroblast	fibroblast	ADJ
arestyrurj-171	68	12	cells	cell	NOUN
arestyrurj-171	68	13	.	.	PUNCT
arestyrurj-171	69	1	images	image	NOUN
arestyrurj-171	69	2	were	be	AUX
arestyrurj-171	69	3	taken	take	VERB
arestyrurj-171	69	4	with	with	ADP
arestyrurj-171	69	5	the	the	DET
arestyrurj-171	69	6	epifluorescent	epifluorescent	ADJ
arestyrurj-171	69	7	revolve	revolve	NOUN
arestyrurj-171	69	8	microscope	microscope	NOUN
arestyrurj-171	69	9	at	at	ADP
arestyrurj-171	69	10	40x	40x	NOUN
arestyrurj-171	69	11	magnification	magnification	PROPN
arestyrurj-171	69	12	.	.	PUNCT
arestyrurj-171	70	1	fluorescent	fluorescent	ADJ
arestyrurj-171	70	2	intensities	intensity	NOUN
arestyrurj-171	70	3	of	of	ADP
arestyrurj-171	70	4	the	the	DET
arestyrurj-171	70	5	subcellular	subcellular	ADJ
arestyrurj-171	70	6	structures	structure	NOUN
arestyrurj-171	70	7	stained	stain	VERB
arestyrurj-171	70	8	with	with	ADP
arestyrurj-171	70	9	filipin	filipin	NOUN
arestyrurj-171	70	10	were	be	AUX
arestyrurj-171	70	11	analyzed	analyze	VERB
arestyrurj-171	70	12	using	use	VERB
arestyrurj-171	70	13	image	image	NOUN
arestyrurj-171	70	14	j	j	PROPN
arestyrurj-171	70	15	software	software	NOUN
arestyrurj-171	70	16	as	as	ADP
arestyrurj-171	70	17	described	describe	VERB
arestyrurj-171	70	18	by.[11	by.[11	NOUN
arestyrurj-171	70	19	]	]	X
arestyrurj-171	70	20	3	3	NUM
arestyrurj-171	70	21	results	result	NOUN
arestyrurj-171	70	22	fluorescent	fluorescent	ADJ
arestyrurj-171	70	23	microscopy	microscopy	NOUN
arestyrurj-171	70	24	detects	detect	NOUN
arestyrurj-171	70	25	the	the	DET
arestyrurj-171	70	26	intensity	intensity	NOUN
arestyrurj-171	70	27	of	of	ADP
arestyrurj-171	70	28	filipin	filipin	NOUN
arestyrurj-171	70	29	from	from	ADP
arestyrurj-171	70	30	the	the	DET
arestyrurj-171	70	31	coverslips	coverslip	NOUN
arestyrurj-171	70	32	on	on	ADP
arestyrurj-171	70	33	which	which	PRON
arestyrurj-171	70	34	the	the	DET
arestyrurj-171	70	35	cells	cell	NOUN
arestyrurj-171	70	36	were	be	AUX
arestyrurj-171	70	37	fixed	fix	VERB
arestyrurj-171	70	38	(	(	PUNCT
arestyrurj-171	70	39	figure	figure	NOUN
arestyrurj-171	70	40	5	5	NUM
arestyrurj-171	70	41	)	)	PUNCT
arestyrurj-171	70	42	.	.	PUNCT
arestyrurj-171	71	1	filipin	filipin	NOUN
arestyrurj-171	71	2	binds	bind	VERB
arestyrurj-171	71	3	to	to	ADP
arestyrurj-171	71	4	cholesterol	cholesterol	NOUN
arestyrurj-171	71	5	;	;	PUNCT
arestyrurj-171	71	6	the	the	PRON
arestyrurj-171	71	7	higher	high	ADJ
arestyrurj-171	71	8	the	the	DET
arestyrurj-171	71	9	filipin	filipin	NOUN
arestyrurj-171	71	10	intensity	intensity	NOUN
arestyrurj-171	71	11	,	,	PUNCT
arestyrurj-171	71	12	the	the	PRON
arestyrurj-171	71	13	higher	high	ADJ
arestyrurj-171	71	14	the	the	DET
arestyrurj-171	71	15	cholesterol	cholesterol	NOUN
arestyrurj-171	71	16	levels	level	NOUN
arestyrurj-171	71	17	in	in	ADP
arestyrurj-171	71	18	the	the	DET
arestyrurj-171	71	19	cells	cell	NOUN
arestyrurj-171	71	20	.	.	PUNCT
arestyrurj-171	72	1	the	the	DET
arestyrurj-171	72	2	results	result	NOUN
arestyrurj-171	72	3	of	of	ADP
arestyrurj-171	72	4	the	the	DET
arestyrurj-171	72	5	fluorescent	fluorescent	ADJ
arestyrurj-171	72	6	microscopy	microscopy	NOUN
arestyrurj-171	72	7	are	be	AUX
arestyrurj-171	72	8	shown	show	VERB
arestyrurj-171	72	9	in	in	ADP
arestyrurj-171	72	10	figure	figure	NOUN
arestyrurj-171	72	11	6	6	NUM
arestyrurj-171	72	12	.	.	PUNCT
arestyrurj-171	73	1	scr	scr	NOUN
arestyrurj-171	73	2	control	control	NOUN
arestyrurj-171	73	3	is	be	AUX
arestyrurj-171	73	4	a	a	DET
arestyrurj-171	73	5	control	control	NOUN
arestyrurj-171	73	6	group	group	NOUN
arestyrurj-171	73	7	that	that	PRON
arestyrurj-171	73	8	is	be	AUX
arestyrurj-171	73	9	npc-1	npc-1	NOUN
arestyrurj-171	73	10	deficient	deficient	ADJ
arestyrurj-171	73	11	only	only	ADV
arestyrurj-171	73	12	.	.	PUNCT
arestyrurj-171	74	1	scr+pg	scr+pg	NOUN
arestyrurj-171	74	2	is	be	AUX
arestyrurj-171	74	3	a	a	DET
arestyrurj-171	74	4	pg	pg	ADV
arestyrurj-171	74	5	-	-	PUNCT
arestyrurj-171	74	6	treated	treat	VERB
arestyrurj-171	74	7	group	group	NOUN
arestyrurj-171	74	8	that	that	PRON
arestyrurj-171	74	9	is	be	AUX
arestyrurj-171	74	10	npc-1	npc-1	NOUN
arestyrurj-171	74	11	deficient	deficient	ADJ
arestyrurj-171	74	12	only	only	ADV
arestyrurj-171	74	13	.	.	PUNCT
arestyrurj-171	75	1	both	both	PRON
arestyrurj-171	75	2	of	of	ADP
arestyrurj-171	75	3	these	these	DET
arestyrurj-171	75	4	groups	group	NOUN
arestyrurj-171	75	5	came	come	VERB
arestyrurj-171	75	6	from	from	ADP
arestyrurj-171	75	7	the	the	DET
arestyrurj-171	75	8	control	control	NOUN
arestyrurj-171	75	9	cell	cell	NOUN
arestyrurj-171	75	10	line	line	NOUN
arestyrurj-171	75	11	that	that	PRON
arestyrurj-171	75	12	received	receive	VERB
arestyrurj-171	75	13	the	the	DET
arestyrurj-171	75	14	scrambled	scramble	VERB
arestyrurj-171	75	15	control	control	NOUN
arestyrurj-171	75	16	shrna	shrna	PROPN
arestyrurj-171	75	17	.	.	PUNCT
arestyrurj-171	76	1	atg12	atg12	PROPN
arestyrurj-171	76	2	kd	kd	PROPN
arestyrurj-171	76	3	control	control	PROPN
arestyrurj-171	76	4	is	be	AUX
arestyrurj-171	76	5	a	a	DET
arestyrurj-171	76	6	control	control	NOUN
arestyrurj-171	76	7	group	group	NOUN
arestyrurj-171	76	8	that	that	PRON
arestyrurj-171	76	9	is	be	AUX
arestyrurj-171	76	10	both	both	PRON
arestyrurj-171	76	11	npc-1	npc-1	NOUN
arestyrurj-171	76	12	deficient	deficient	ADJ
arestyrurj-171	76	13	and	and	CCONJ
arestyrurj-171	76	14	has	have	AUX
arestyrurj-171	76	15	autophagy	autophagy	VERB
arestyrurj-171	76	16	blocked	block	VERB
arestyrurj-171	76	17	.	.	PUNCT
arestyrurj-171	77	1	atg12	atg12	PROPN
arestyrurj-171	77	2	kd	kd	PROPN
arestyrurj-171	78	1	+	+	CCONJ
arestyrurj-171	78	2	pg	pg	PROPN
arestyrurj-171	78	3	is	be	AUX
arestyrurj-171	78	4	a	a	DET
arestyrurj-171	78	5	pg	pg	ADV
arestyrurj-171	78	6	-	-	PUNCT
arestyrurj-171	78	7	treated	treat	VERB
arestyrurj-171	78	8	group	group	NOUN
arestyrurj-171	78	9	that	that	PRON
arestyrurj-171	78	10	is	be	AUX
arestyrurj-171	78	11	npc-1	npc-1	NOUN
arestyrurj-171	78	12	deficient	deficient	ADJ
arestyrurj-171	78	13	and	and	CCONJ
arestyrurj-171	78	14	has	have	AUX
arestyrurj-171	78	15	autophagy	autophagy	VERB
arestyrurj-171	78	16	blocked	block	VERB
arestyrurj-171	78	17	.	.	PUNCT
arestyrurj-171	79	1	both	both	PRON
arestyrurj-171	79	2	of	of	ADP
arestyrurj-171	79	3	these	these	DET
arestyrurj-171	79	4	groups	group	NOUN
arestyrurj-171	79	5	have	have	AUX
arestyrurj-171	79	6	autophagy	autophagy	VERB
arestyrurj-171	79	7	blocked	block	VERB
arestyrurj-171	79	8	because	because	SCONJ
arestyrurj-171	79	9	they	they	PRON
arestyrurj-171	79	10	came	come	VERB
arestyrurj-171	79	11	from	from	ADP
arestyrurj-171	79	12	the	the	DET
arestyrurj-171	79	13	autophagy	autophagy	ADJ
arestyrurj-171	79	14	knockout	knockout	NOUN
arestyrurj-171	79	15	cell	cell	NOUN
arestyrurj-171	79	16	line	line	NOUN
arestyrurj-171	79	17	that	that	PRON
arestyrurj-171	79	18	received	receive	VERB
arestyrurj-171	79	19	the	the	DET
arestyrurj-171	79	20	atg12	atg12	PROPN
arestyrurj-171	79	21	shrna	shrna	NOUN
arestyrurj-171	79	22	.	.	PUNCT
arestyrurj-171	80	1	the	the	DET
arestyrurj-171	80	2	untreated	untreated	ADJ
arestyrurj-171	80	3	control	control	NOUN
arestyrurj-171	80	4	groups	group	NOUN
arestyrurj-171	80	5	provide	provide	VERB
arestyrurj-171	80	6	the	the	DET
arestyrurj-171	80	7	baseline	baseline	NOUN
arestyrurj-171	80	8	filipin	filipin	NOUN
arestyrurj-171	80	9	intensity	intensity	NOUN
arestyrurj-171	80	10	for	for	ADP
arestyrurj-171	80	11	each	each	DET
arestyrurj-171	80	12	cell	cell	NOUN
arestyrurj-171	80	13	line	line	NOUN
arestyrurj-171	80	14	.	.	PUNCT
arestyrurj-171	81	1	figure	figure	NOUN
arestyrurj-171	81	2	6	6	NUM
arestyrurj-171	81	3	shows	show	VERB
arestyrurj-171	81	4	that	that	SCONJ
arestyrurj-171	81	5	there	there	PRON
arestyrurj-171	81	6	is	be	VERB
arestyrurj-171	81	7	a	a	DET
arestyrurj-171	81	8	statistically	statistically	ADV
arestyrurj-171	81	9	significant	significant	ADJ
arestyrurj-171	81	10	difference	difference	NOUN
arestyrurj-171	81	11	in	in	ADP
arestyrurj-171	81	12	cholesterol	cholesterol	NOUN
arestyrurj-171	81	13	content	content	NOUN
arestyrurj-171	81	14	between	between	ADP
arestyrurj-171	81	15	the	the	DET
arestyrurj-171	81	16	scr	scr	NOUN
arestyrurj-171	81	17	control	control	NOUN
arestyrurj-171	81	18	and	and	CCONJ
arestyrurj-171	81	19	scr+pg	scr+pg	NOUN
arestyrurj-171	81	20	groups	group	NOUN
arestyrurj-171	81	21	,	,	PUNCT
arestyrurj-171	81	22	with	with	ADP
arestyrurj-171	81	23	scr+pg	scr+pg	NOUN
arestyrurj-171	81	24	having	have	VERB
arestyrurj-171	81	25	less	less	ADJ
arestyrurj-171	81	26	cholesterol	cholesterol	NOUN
arestyrurj-171	81	27	.	.	PUNCT
arestyrurj-171	82	1	this	this	PRON
arestyrurj-171	82	2	is	be	AUX
arestyrurj-171	82	3	in	in	ADP
arestyrurj-171	82	4	agreement	agreement	NOUN
arestyrurj-171	82	5	with	with	ADP
arestyrurj-171	82	6	the	the	DET
arestyrurj-171	82	7	previous	previous	ADJ
arestyrurj-171	82	8	finding	finding	NOUN
arestyrurj-171	82	9	that	that	PRON
arestyrurj-171	82	10	pg	pg	PROPN
arestyrurj-171	82	11	supplementation	supplementation	NOUN
arestyrurj-171	82	12	increases	increase	VERB
arestyrurj-171	82	13	lbpa	lbpa	NOUN
arestyrurj-171	82	14	levels	level	NOUN
arestyrurj-171	82	15	and	and	CCONJ
arestyrurj-171	82	16	thus	thus	ADV
arestyrurj-171	82	17	decreases	decrease	VERB
arestyrurj-171	82	18	cholesterol	cholesterol	NOUN
arestyrurj-171	82	19	content.[14	content.[14	PROPN
arestyrurj-171	82	20	]	]	PUNCT
arestyrurj-171	82	21	the	the	DET
arestyrurj-171	82	22	red	red	ADJ
arestyrurj-171	82	23	bracket	bracket	NOUN
arestyrurj-171	82	24	in	in	ADP
arestyrurj-171	82	25	figure	figure	NOUN
arestyrurj-171	82	26	6	6	NUM
arestyrurj-171	82	27	shows	show	VERB
arestyrurj-171	82	28	that	that	SCONJ
arestyrurj-171	82	29	atg12	atg12	PROPN
arestyrurj-171	82	30	kd+pg	kd+pg	NOUN
arestyrurj-171	82	31	has	have	VERB
arestyrurj-171	82	32	significantly	significantly	ADV
arestyrurj-171	82	33	more	more	ADJ
arestyrurj-171	82	34	cholesterol	cholesterol	NOUN
arestyrurj-171	82	35	than	than	ADP
arestyrurj-171	82	36	scr+pg	scr+pg	NOUN
arestyrurj-171	82	37	.	.	PUNCT
arestyrurj-171	83	1	this	this	PRON
arestyrurj-171	83	2	shows	show	VERB
arestyrurj-171	83	3	that	that	SCONJ
arestyrurj-171	83	4	autophagy	autophagy	NOUN
arestyrurj-171	83	5	is	be	AUX
arestyrurj-171	83	6	a	a	DET
arestyrurj-171	83	7	partial	partial	ADJ
arestyrurj-171	83	8	route	route	NOUN
arestyrurj-171	83	9	in	in	ADP
arestyrurj-171	83	10	cholesterol	cholesterol	NOUN
arestyrurj-171	83	11	clearance	clearance	NOUN
arestyrurj-171	83	12	during	during	ADP
arestyrurj-171	83	13	pg	pg	NOUN
arestyrurj-171	83	14	treatment	treatment	NOUN
arestyrurj-171	83	15	,	,	PUNCT
arestyrurj-171	83	16	since	since	SCONJ
arestyrurj-171	83	17	the	the	DET
arestyrurj-171	83	18	pg	pg	PROPN
arestyrurj-171	83	19	treatment	treatment	NOUN
arestyrurj-171	83	20	was	be	AUX
arestyrurj-171	83	21	less	less	ADV
arestyrurj-171	83	22	effective	effective	ADJ
arestyrurj-171	83	23	when	when	SCONJ
arestyrurj-171	83	24	autophagy	autophagy	NOUN
arestyrurj-171	83	25	was	be	AUX
arestyrurj-171	83	26	blocked	block	VERB
arestyrurj-171	83	27	.	.	PUNCT
arestyrurj-171	84	1	lastly	lastly	ADV
arestyrurj-171	84	2	,	,	PUNCT
arestyrurj-171	84	3	figure	figure	VERB
arestyrurj-171	84	4	6	6	NUM
arestyrurj-171	84	5	shows	show	NOUN
arestyrurj-171	84	6	that	that	SCONJ
arestyrurj-171	84	7	atg12	atg12	PROPN
arestyrurj-171	84	8	kd+pg	kd+pg	NOUN
arestyrurj-171	84	9	has	have	VERB
arestyrurj-171	84	10	significantly	significantly	ADV
arestyrurj-171	84	11	less	less	ADJ
arestyrurj-171	84	12	cholesterol	cholesterol	NOUN
arestyrurj-171	84	13	than	than	ADP
arestyrurj-171	84	14	atg	atg	PROPN
arestyrurj-171	84	15	kd	kd	PROPN
arestyrurj-171	84	16	control	control	PROPN
arestyrurj-171	84	17	.	.	PUNCT
arestyrurj-171	85	1	this	this	PRON
arestyrurj-171	85	2	indicates	indicate	VERB
arestyrurj-171	85	3	that	that	SCONJ
arestyrurj-171	85	4	autophagy	autophagy	NOUN
arestyrurj-171	85	5	is	be	AUX
arestyrurj-171	85	6	not	not	PART
arestyrurj-171	85	7	the	the	DET
arestyrurj-171	85	8	major	major	ADJ
arestyrurj-171	85	9	underlying	underlying	ADJ
arestyrurj-171	85	10	mechanism	mechanism	NOUN
arestyrurj-171	85	11	for	for	ADP
arestyrurj-171	85	12	pg	pg	NOUN
arestyrurj-171	85	13	/	/	SYM
arestyrurj-171	85	14	lbpa	lbpa	ADV
arestyrurj-171	85	15	-	-	PUNCT
arestyrurj-171	85	16	induced	induce	VERB
arestyrurj-171	85	17	cholesterol	cholesterol	NOUN
arestyrurj-171	85	18	efflux	efflux	NOUN
arestyrurj-171	85	19	since	since	SCONJ
arestyrurj-171	85	20	pg	pg	NOUN
arestyrurj-171	85	21	treatment	treatment	NOUN
arestyrurj-171	85	22	had	have	VERB
arestyrurj-171	85	23	an	an	DET
arestyrurj-171	85	24	effect	effect	NOUN
arestyrurj-171	85	25	even	even	ADV
arestyrurj-171	85	26	when	when	SCONJ
arestyrurj-171	85	27	autophagy	autophagy	NOUN
arestyrurj-171	85	28	was	be	AUX
arestyrurj-171	85	29	blocked	block	VERB
arestyrurj-171	85	30	.	.	PUNCT
arestyrurj-171	86	1	this	this	PRON
arestyrurj-171	86	2	is	be	AUX
arestyrurj-171	86	3	also	also	ADV
arestyrurj-171	86	4	suggested	suggest	VERB
arestyrurj-171	86	5	by	by	ADP
arestyrurj-171	86	6	the	the	DET
arestyrurj-171	86	7	fact	fact	NOUN
arestyrurj-171	86	8	that	that	SCONJ
arestyrurj-171	86	9	there	there	PRON
arestyrurj-171	86	10	is	be	VERB
arestyrurj-171	86	11	only	only	ADV
arestyrurj-171	86	12	15	15	NUM
arestyrurj-171	86	13	%	%	NOUN
arestyrurj-171	86	14	more	more	ADJ
arestyrurj-171	86	15	cholesterol	cholesterol	NOUN
arestyrurj-171	86	16	in	in	ADP
arestyrurj-171	86	17	atg12	atg12	PROPN
arestyrurj-171	86	18	kd+pg	kd+pg	VERB
arestyrurj-171	86	19	than	than	ADP
arestyrurj-171	86	20	in	in	ADP
arestyrurj-171	86	21	scr+pg	scr+pg	NOUN
arestyrurj-171	86	22	;	;	PUNCT
arestyrurj-171	86	23	there	there	PRON
arestyrurj-171	86	24	would	would	AUX
arestyrurj-171	86	25	be	be	AUX
arestyrurj-171	86	26	closer	close	ADJ
arestyrurj-171	86	27	to	to	PART
arestyrurj-171	86	28	100	100	NUM
arestyrurj-171	86	29	%	%	NOUN
arestyrurj-171	86	30	more	more	ADJ
arestyrurj-171	86	31	cholesterol	cholesterol	NOUN
arestyrurj-171	86	32	in	in	ADP
arestyrurj-171	86	33	atg12	atg12	PROPN
arestyrurj-171	86	34	aresty	aresty	PROPN
arestyrurj-171	86	35	rutgers	rutgers	PROPN
arestyrurj-171	86	36	undergraduate	undergraduate	PROPN
arestyrurj-171	86	37	research	research	PROPN
arestyrurj-171	86	38	journal	journal	PROPN
arestyrurj-171	86	39	,	,	PUNCT
arestyrurj-171	86	40	volume	volume	NOUN
arestyrurj-171	86	41	i	i	PRON
arestyrurj-171	86	42	,	,	PUNCT
arestyrurj-171	86	43	issue	issue	VERB
arestyrurj-171	86	44	iii	iii	NUM
arestyrurj-171	86	45	kd+pg	kd+pg	NOUN
arestyrurj-171	86	46	if	if	SCONJ
arestyrurj-171	86	47	autophagy	autophagy	NOUN
arestyrurj-171	86	48	was	be	AUX
arestyrurj-171	86	49	a	a	DET
arestyrurj-171	86	50	major	major	ADJ
arestyrurj-171	86	51	route	route	NOUN
arestyrurj-171	86	52	in	in	ADP
arestyrurj-171	86	53	cholesterol	cholesterol	NOUN
arestyrurj-171	86	54	clearance	clearance	NOUN
arestyrurj-171	86	55	.	.	PUNCT
arestyrurj-171	87	1	the	the	DET
arestyrurj-171	87	2	statistical	statistical	ADJ
arestyrurj-171	87	3	tests	test	NOUN
arestyrurj-171	87	4	were	be	AUX
arestyrurj-171	87	5	t	t	NOUN
arestyrurj-171	87	6	-	-	PUNCT
arestyrurj-171	87	7	tests	test	NOUN
arestyrurj-171	87	8	using	use	VERB
arestyrurj-171	87	9	a	a	DET
arestyrurj-171	87	10	significance	significance	NOUN
arestyrurj-171	87	11	level	level	NOUN
arestyrurj-171	87	12	of	of	ADP
arestyrurj-171	87	13	0.01	0.01	NUM
arestyrurj-171	87	14	and	and	CCONJ
arestyrurj-171	87	15	all	all	DET
arestyrurj-171	87	16	three	three	NUM
arestyrurj-171	87	17	tests	test	NOUN
arestyrurj-171	87	18	produced	produce	VERB
arestyrurj-171	87	19	a	a	DET
arestyrurj-171	87	20	p	p	NOUN
arestyrurj-171	87	21	value	value	NOUN
arestyrurj-171	87	22	of	of	ADP
arestyrurj-171	87	23	less	less	ADJ
arestyrurj-171	87	24	than	than	ADP
arestyrurj-171	87	25	0.001	0.001	NUM
arestyrurj-171	87	26	,	,	PUNCT
arestyrurj-171	87	27	as	as	SCONJ
arestyrurj-171	87	28	indicated	indicate	VERB
arestyrurj-171	87	29	by	by	ADP
arestyrurj-171	87	30	the	the	DET
arestyrurj-171	87	31	asterisks	asterisk	NOUN
arestyrurj-171	87	32	.	.	PUNCT
arestyrurj-171	88	1	4	4	NUM
arestyrurj-171	88	2	discussion	discussion	NOUN
arestyrurj-171	88	3	the	the	DET
arestyrurj-171	88	4	statistically	statistically	ADV
arestyrurj-171	88	5	significant	significant	ADJ
arestyrurj-171	88	6	results	result	NOUN
arestyrurj-171	88	7	between	between	ADP
arestyrurj-171	88	8	scr+pg	scr+pg	NOUN
arestyrurj-171	88	9	and	and	CCONJ
arestyrurj-171	88	10	atg12	atg12	PROPN
arestyrurj-171	88	11	kd+pg	kd+pg	NOUN
arestyrurj-171	88	12	indicate	indicate	VERB
arestyrurj-171	88	13	that	that	SCONJ
arestyrurj-171	88	14	autophagy	autophagy	NOUN
arestyrurj-171	88	15	is	be	AUX
arestyrurj-171	88	16	blocked	block	VERB
arestyrurj-171	88	17	in	in	ADP
arestyrurj-171	88	18	npc	npc	NOUN
arestyrurj-171	88	19	disease	disease	NOUN
arestyrurj-171	88	20	due	due	ADP
arestyrurj-171	88	21	to	to	ADP
arestyrurj-171	88	22	an	an	DET
arestyrurj-171	88	23	inability	inability	NOUN
arestyrurj-171	88	24	of	of	ADP
arestyrurj-171	88	25	the	the	DET
arestyrurj-171	88	26	autophagosome	autophagosome	NOUN
arestyrurj-171	88	27	to	to	PART
arestyrurj-171	88	28	fuse	fuse	VERB
arestyrurj-171	88	29	with	with	ADP
arestyrurj-171	88	30	the	the	DET
arestyrurj-171	88	31	lysosome	lysosome	NOUN
arestyrurj-171	88	32	and	and	CCONJ
arestyrurj-171	88	33	this	this	DET
arestyrurj-171	88	34	impaired	impair	VERB
arestyrurj-171	88	35	ability	ability	NOUN
arestyrurj-171	88	36	is	be	AUX
arestyrurj-171	88	37	restored	restore	VERB
arestyrurj-171	88	38	by	by	ADP
arestyrurj-171	88	39	pg	pg	PROPN
arestyrurj-171	88	40	/	/	SYM
arestyrurj-171	88	41	lbpa	lbpa	NOUN
arestyrurj-171	88	42	enrichment	enrichment	NOUN
arestyrurj-171	88	43	in	in	ADP
arestyrurj-171	88	44	npc-1	npc-1	NOUN
arestyrurj-171	88	45	cells	cell	NOUN
arestyrurj-171	88	46	,	,	PUNCT
arestyrurj-171	88	47	ince	ince	VERB
arestyrurj-171	88	48	the	the	DET
arestyrurj-171	88	49	inner	inner	ADJ
arestyrurj-171	88	50	-	-	PUNCT
arestyrurj-171	88	51	lysosomal	lysosomal	ADJ
arestyrurj-171	88	52	portion	portion	NOUN
arestyrurj-171	88	53	of	of	ADP
arestyrurj-171	88	54	the	the	DET
arestyrurj-171	88	55	npc-1	npc-1	NOUN
arestyrurj-171	88	56	protein	protein	NOUN
arestyrurj-171	88	57	is	be	AUX
arestyrurj-171	88	58	thought	think	VERB
arestyrurj-171	88	59	to	to	PART
arestyrurj-171	88	60	be	be	AUX
arestyrurj-171	88	61	required	require	VERB
arestyrurj-171	88	62	for	for	SCONJ
arestyrurj-171	88	63	cholesterol	cholesterol	NOUN
arestyrurj-171	88	64	to	to	PART
arestyrurj-171	88	65	penetrate	penetrate	VERB
arestyrurj-171	88	66	through	through	ADP
arestyrurj-171	88	67	the	the	DET
arestyrurj-171	88	68	glycocalyx	glycocalyx	NOUN
arestyrurj-171	88	69	that	that	PRON
arestyrurj-171	88	70	coats	coat	VERB
arestyrurj-171	88	71	the	the	DET
arestyrurj-171	88	72	limiting	limit	VERB
arestyrurj-171	88	73	lysosomal	lysosomal	ADJ
arestyrurj-171	88	74	membrane	membrane	NOUN
arestyrurj-171	88	75	,	,	PUNCT
arestyrurj-171	88	76	enhanced	enhance	VERB
arestyrurj-171	88	77	autolysosome	autolysosome	NOUN
arestyrurj-171	88	78	formation	formation	NOUN
arestyrurj-171	88	79	during	during	ADP
arestyrurj-171	88	80	pg	pg	PROPN
arestyrurj-171	88	81	/	/	SYM
arestyrurj-171	88	82	lbpa	lbpa	NOUN
arestyrurj-171	88	83	enrichment	enrichment	NOUN
arestyrurj-171	88	84	could	could	AUX
arestyrurj-171	88	85	potentially	potentially	ADV
arestyrurj-171	88	86	provide	provide	VERB
arestyrurj-171	88	87	a	a	DET
arestyrurj-171	88	88	route	route	NOUN
arestyrurj-171	88	89	for	for	ADP
arestyrurj-171	88	90	cholesterol	cholesterol	NOUN
arestyrurj-171	88	91	egress	egress	NOUN
arestyrurj-171	88	92	that	that	PRON
arestyrurj-171	88	93	bypasses	bypass	VERB
arestyrurj-171	88	94	the	the	DET
arestyrurj-171	88	95	glycocalyx.[11,12,13,22,23	glycocalyx.[11,12,13,22,23	PROPN
arestyrurj-171	88	96	]	]	PUNCT
arestyrurj-171	88	97	we	we	PRON
arestyrurj-171	88	98	hypothesize	hypothesize	VERB
arestyrurj-171	88	99	that	that	SCONJ
arestyrurj-171	88	100	the	the	DET
arestyrurj-171	88	101	glycocalyx	glycocalyx	NOUN
arestyrurj-171	88	102	of	of	ADP
arestyrurj-171	88	103	the	the	DET
arestyrurj-171	88	104	lysosome	lysosome	NOUN
arestyrurj-171	88	105	may	may	AUX
arestyrurj-171	88	106	become	become	VERB
arestyrurj-171	88	107	weakened	weaken	VERB
arestyrurj-171	88	108	when	when	SCONJ
arestyrurj-171	88	109	the	the	DET
arestyrurj-171	88	110	autophagosome	autophagosome	NOUN
arestyrurj-171	88	111	fuses	fuse	VERB
arestyrurj-171	88	112	with	with	ADP
arestyrurj-171	88	113	the	the	DET
arestyrurj-171	88	114	lysosome	lysosome	NOUN
arestyrurj-171	88	115	,	,	PUNCT
arestyrurj-171	88	116	allowing	allow	VERB
arestyrurj-171	88	117	cholesterol	cholesterol	NOUN
arestyrurj-171	88	118	to	to	PART
arestyrurj-171	88	119	more	more	ADV
arestyrurj-171	88	120	readily	readily	ADV
arestyrurj-171	88	121	reach	reach	VERB
arestyrurj-171	88	122	the	the	DET
arestyrurj-171	88	123	limiting	limit	VERB
arestyrurj-171	88	124	membrane	membrane	NOUN
arestyrurj-171	88	125	of	of	ADP
arestyrurj-171	88	126	the	the	DET
arestyrurj-171	88	127	lysosome	lysosome	NOUN
arestyrurj-171	88	128	,	,	PUNCT
arestyrurj-171	88	129	and	and	CCONJ
arestyrurj-171	88	130	therefore	therefore	ADV
arestyrurj-171	88	131	more	more	ADV
arestyrurj-171	88	132	readily	readily	ADV
arestyrurj-171	88	133	exit	exit	VERB
arestyrurj-171	88	134	the	the	DET
arestyrurj-171	88	135	compartment	compartment	NOUN
arestyrurj-171	88	136	.	.	PUNCT
arestyrurj-171	88	137	npc-1	npc-1	NOUN
arestyrurj-171	88	138	disease	disease	NOUN
arestyrurj-171	88	139	shares	share	VERB
arestyrurj-171	88	140	many	many	ADJ
arestyrurj-171	88	141	similarities	similarity	NOUN
arestyrurj-171	88	142	with	with	ADP
arestyrurj-171	88	143	alzheimer	alzheimer	PROPN
arestyrurj-171	88	144	’s	’s	PART
arestyrurj-171	88	145	disease.[3	disease.[3	NOUN
arestyrurj-171	88	146	]	]	PUNCT
arestyrurj-171	88	147	increased	increase	VERB
arestyrurj-171	88	148	endogenous	endogenous	ADJ
arestyrurj-171	88	149	lbpa	lbpa	NOUN
arestyrurj-171	88	150	has	have	AUX
arestyrurj-171	88	151	been	be	AUX
arestyrurj-171	88	152	reported	report	VERB
arestyrurj-171	88	153	in	in	ADP
arestyrurj-171	88	154	both	both	DET
arestyrurj-171	88	155	npc-1[6	npc-1[6	NOUN
arestyrurj-171	88	156	]	]	PUNCT
arestyrurj-171	88	157	and	and	CCONJ
arestyrurj-171	88	158	alzheimer	alzheimer	PROPN
arestyrurj-171	88	159	’s	’s	PART
arestyrurj-171	88	160	disease,[4	disease,[4	PROPN
arestyrurj-171	88	161	]	]	PUNCT
arestyrurj-171	88	162	where	where	SCONJ
arestyrurj-171	88	163	such	such	DET
arestyrurj-171	88	164	an	an	DET
arestyrurj-171	88	165	increase	increase	NOUN
arestyrurj-171	88	166	might	might	AUX
arestyrurj-171	88	167	be	be	AUX
arestyrurj-171	88	168	a	a	DET
arestyrurj-171	88	169	compensatory	compensatory	ADJ
arestyrurj-171	88	170	homeostatic	homeostatic	ADJ
arestyrurj-171	88	171	cellular	cellular	ADJ
arestyrurj-171	88	172	response	response	NOUN
arestyrurj-171	88	173	to	to	PART
arestyrurj-171	88	174	eliminate	eliminate	VERB
arestyrurj-171	88	175	toxic	toxic	ADJ
arestyrurj-171	88	176	deposits	deposit	NOUN
arestyrurj-171	88	177	.	.	PUNCT
arestyrurj-171	89	1	therefore	therefore	ADV
arestyrurj-171	89	2	,	,	PUNCT
arestyrurj-171	89	3	pg	pg	PROPN
arestyrurj-171	89	4	/	/	SYM
arestyrurj-171	89	5	lbpa	lbpa	PROPN
arestyrurj-171	89	6	enrichment	enrichment	NOUN
arestyrurj-171	89	7	has	have	VERB
arestyrurj-171	89	8	great	great	ADJ
arestyrurj-171	89	9	potential	potential	NOUN
arestyrurj-171	89	10	for	for	ADP
arestyrurj-171	89	11	the	the	DET
arestyrurj-171	89	12	treatment	treatment	NOUN
arestyrurj-171	89	13	of	of	ADP
arestyrurj-171	89	14	npc-1	npc-1	NOUN
arestyrurj-171	89	15	disease	disease	NOUN
arestyrurj-171	89	16	and	and	CCONJ
arestyrurj-171	89	17	potentially	potentially	ADV
arestyrurj-171	89	18	other	other	ADJ
arestyrurj-171	89	19	lysosomal	lysosomal	ADJ
arestyrurj-171	89	20	storage	storage	NOUN
arestyrurj-171	89	21	disorders	disorder	NOUN
arestyrurj-171	89	22	and	and	CCONJ
arestyrurj-171	89	23	neurological	neurological	ADJ
arestyrurj-171	89	24	diseases	disease	NOUN
arestyrurj-171	89	25	with	with	ADP
arestyrurj-171	89	26	autophagy	autophagy	ADJ
arestyrurj-171	89	27	defects	defect	NOUN
arestyrurj-171	89	28	,	,	PUNCT
arestyrurj-171	89	29	such	such	ADJ
arestyrurj-171	89	30	as	as	ADP
arestyrurj-171	89	31	parkinson	parkinson	NOUN
arestyrurj-171	89	32	’s	’s	PART
arestyrurj-171	89	33	or	or	CCONJ
arestyrurj-171	89	34	alzheimer	alzheimer	PROPN
arestyrurj-171	89	35	’s	’s	PART
arestyrurj-171	89	36	disease	disease	NOUN
arestyrurj-171	89	37	.	.	PUNCT
arestyrurj-171	90	1	it	it	PRON
arestyrurj-171	90	2	is	be	AUX
arestyrurj-171	90	3	important	important	ADJ
arestyrurj-171	90	4	to	to	PART
arestyrurj-171	90	5	understand	understand	VERB
arestyrurj-171	90	6	all	all	DET
arestyrurj-171	90	7	processes	process	NOUN
arestyrurj-171	90	8	involved	involve	VERB
arestyrurj-171	90	9	in	in	ADP
arestyrurj-171	90	10	cholesterol	cholesterol	NOUN
arestyrurj-171	90	11	clearance	clearance	NOUN
arestyrurj-171	90	12	during	during	ADP
arestyrurj-171	90	13	the	the	DET
arestyrurj-171	90	14	treatment	treatment	NOUN
arestyrurj-171	90	15	,	,	PUNCT
arestyrurj-171	90	16	including	include	VERB
arestyrurj-171	90	17	autophagy	autophagy	NOUN
arestyrurj-171	90	18	.	.	PUNCT
arestyrurj-171	91	1	in	in	ADP
arestyrurj-171	91	2	future	future	ADJ
arestyrurj-171	91	3	work	work	NOUN
arestyrurj-171	91	4	,	,	PUNCT
arestyrurj-171	91	5	to	to	PART
arestyrurj-171	91	6	understand	understand	VERB
arestyrurj-171	91	7	the	the	DET
arestyrurj-171	91	8	extent	extent	NOUN
arestyrurj-171	91	9	of	of	ADP
arestyrurj-171	91	10	autophagy	autophagy	NOUN
arestyrurj-171	91	11	’s	’s	PART
arestyrurj-171	91	12	role	role	NOUN
arestyrurj-171	91	13	in	in	ADP
arestyrurj-171	91	14	cholesterol	cholesterol	NOUN
arestyrurj-171	91	15	clearance	clearance	NOUN
arestyrurj-171	91	16	during	during	ADP
arestyrurj-171	91	17	pg	pg	NOUN
arestyrurj-171	91	18	treatment	treatment	NOUN
arestyrurj-171	91	19	,	,	PUNCT
arestyrurj-171	91	20	we	we	PRON
arestyrurj-171	91	21	will	will	AUX
arestyrurj-171	91	22	block	block	VERB
arestyrurj-171	91	23	autophagy	autophagy	ADV
arestyrurj-171	91	24	by	by	ADP
arestyrurj-171	91	25	silencing	silence	VERB
arestyrurj-171	91	26	other	other	ADJ
arestyrurj-171	91	27	molecules	molecule	NOUN
arestyrurj-171	91	28	,	,	PUNCT
arestyrurj-171	91	29	such	such	ADJ
arestyrurj-171	91	30	as	as	ADP
arestyrurj-171	91	31	atg5	atg5	PROPN
arestyrurj-171	91	32	.	.	PUNCT
arestyrurj-171	92	1	there	there	PRON
arestyrurj-171	92	2	are	be	VERB
arestyrurj-171	92	3	many	many	ADJ
arestyrurj-171	92	4	ways	way	NOUN
arestyrurj-171	92	5	that	that	PRON
arestyrurj-171	92	6	autophagy	autophagy	NOUN
arestyrurj-171	92	7	can	can	AUX
arestyrurj-171	92	8	be	be	AUX
arestyrurj-171	92	9	blocked	block	VERB
arestyrurj-171	92	10	because	because	SCONJ
arestyrurj-171	92	11	there	there	PRON
arestyrurj-171	92	12	are	be	VERB
arestyrurj-171	92	13	many	many	ADJ
arestyrurj-171	92	14	essential	essential	ADJ
arestyrurj-171	92	15	proteins	protein	NOUN
arestyrurj-171	92	16	to	to	ADP
arestyrurj-171	92	17	the	the	DET
arestyrurj-171	92	18	process	process	NOUN
arestyrurj-171	92	19	that	that	PRON
arestyrurj-171	92	20	can	can	AUX
arestyrurj-171	92	21	be	be	AUX
arestyrurj-171	92	22	silenced	silence	VERB
arestyrurj-171	92	23	.	.	PUNCT
arestyrurj-171	93	1	silencing	silence	VERB
arestyrurj-171	93	2	some	some	DET
arestyrurj-171	93	3	genes	gene	NOUN
arestyrurj-171	93	4	for	for	ADP
arestyrurj-171	93	5	autophagy	autophagy	ADJ
arestyrurj-171	93	6	proteins	protein	NOUN
arestyrurj-171	93	7	may	may	AUX
arestyrurj-171	93	8	result	result	VERB
arestyrurj-171	93	9	in	in	ADP
arestyrurj-171	93	10	a	a	DET
arestyrurj-171	93	11	more	more	ADV
arestyrurj-171	93	12	complete	complete	ADJ
arestyrurj-171	93	13	knockdown	knockdown	NOUN
arestyrurj-171	93	14	than	than	ADP
arestyrurj-171	93	15	silencing	silence	VERB
arestyrurj-171	93	16	other	other	ADJ
arestyrurj-171	93	17	genes	gene	NOUN
arestyrurj-171	93	18	.	.	PUNCT
arestyrurj-171	94	1	figure	figure	VERB
arestyrurj-171	94	2	5	5	NUM
arestyrurj-171	94	3	:	:	PUNCT
arestyrurj-171	94	4	sample	sample	NOUN
arestyrurj-171	94	5	of	of	ADP
arestyrurj-171	94	6	images	image	NOUN
arestyrurj-171	94	7	of	of	ADP
arestyrurj-171	94	8	npc-1	npc-1	NOUN
arestyrurj-171	94	9	fibroblast	fibroblast	ADJ
arestyrurj-171	94	10	cells	cell	NOUN
arestyrurj-171	94	11	in	in	ADP
arestyrurj-171	94	12	each	each	DET
arestyrurj-171	94	13	condition	condition	NOUN
arestyrurj-171	94	14	,	,	PUNCT
arestyrurj-171	94	15	filipin	filipin	NOUN
arestyrurj-171	94	16	stained	stain	VERB
arestyrurj-171	94	17	.	.	PUNCT
arestyrurj-171	95	1	figure	figure	VERB
arestyrurj-171	95	2	6	6	NUM
arestyrurj-171	95	3	:	:	PUNCT
arestyrurj-171	95	4	quantification	quantification	NOUN
arestyrurj-171	95	5	of	of	ADP
arestyrurj-171	95	6	filipin	filipin	NOUN
arestyrurj-171	95	7	intensity	intensity	NOUN
arestyrurj-171	95	8	in	in	ADP
arestyrurj-171	95	9	npc1	npc1	NOUN
arestyrurj-171	95	10	-	-	PUNCT
arestyrurj-171	95	11	deficient	deficient	ADJ
arestyrurj-171	95	12	fibroblasts	fibroblast	NOUN
arestyrurj-171	95	13	stably	stably	ADV
arestyrurj-171	95	14	transduced	transduce	VERB
arestyrurj-171	95	15	with	with	ADP
arestyrurj-171	95	16	lentiviral	lentiviral	ADJ
arestyrurj-171	95	17	non	non	ADJ
arestyrurj-171	95	18	silencing	silence	VERB
arestyrurj-171	95	19	control	control	NOUN
arestyrurj-171	95	20	shrna	shrna	NOUN
arestyrurj-171	95	21	(	(	PUNCT
arestyrurj-171	95	22	scr	scr	NOUN
arestyrurj-171	95	23	)	)	PUNCT
arestyrurj-171	95	24	or	or	CCONJ
arestyrurj-171	95	25	shrna	shrna	ADJ
arestyrurj-171	95	26	targeting	target	VERB
arestyrurj-171	95	27	atg12	atg12	NOUN
arestyrurj-171	95	28	and	and	CCONJ
arestyrurj-171	95	29	selected	select	VERB
arestyrurj-171	95	30	for	for	ADP
arestyrurj-171	95	31	stable	stable	ADJ
arestyrurj-171	95	32	shrna	shrna	NOUN
arestyrurj-171	95	33	expression	expression	NOUN
arestyrurj-171	95	34	.	.	PUNCT
arestyrurj-171	96	1	𝑁𝑁	𝑁𝑁	PROPN
arestyrurj-171	96	2	>	>	X
arestyrurj-171	96	3	500	500	NUM
arestyrurj-171	96	4	cells	cell	NOUN
arestyrurj-171	96	5	/	/	SYM
arestyrurj-171	96	6	condition	condition	NOUN
arestyrurj-171	96	7	.	.	PUNCT
arestyrurj-171	97	1	data	datum	NOUN
arestyrurj-171	97	2	from	from	ADP
arestyrurj-171	97	3	2	2	NUM
arestyrurj-171	97	4	independent	independent	ADJ
arestyrurj-171	97	5	experiments	experiment	NOUN
arestyrurj-171	97	6	.	.	PUNCT
arestyrurj-171	98	1	∗∗∗	∗∗∗	NUM
arestyrurj-171	98	2	signifies	signify	VERB
arestyrurj-171	98	3	a	a	DET
arestyrurj-171	98	4	𝑝𝑝	𝑝𝑝	NOUN
arestyrurj-171	98	5	value	value	NOUN
arestyrurj-171	98	6	<	<	X
arestyrurj-171	98	7	0.001	0.001	NUM
arestyrurj-171	98	8	.	.	PUNCT
arestyrurj-171	99	1	aresty	aresty	PROPN
arestyrurj-171	99	2	rutgers	rutgers	PROPN
arestyrurj-171	99	3	undergraduate	undergraduate	PROPN
arestyrurj-171	99	4	research	research	PROPN
arestyrurj-171	99	5	journal	journal	PROPN
arestyrurj-171	99	6	,	,	PUNCT
arestyrurj-171	99	7	volume	volume	NOUN
arestyrurj-171	99	8	i	i	PRON
arestyrurj-171	99	9	,	,	PUNCT
arestyrurj-171	99	10	issue	issue	VERB
arestyrurj-171	99	11	iii	iii	NUM
arestyrurj-171	99	12	patients	patient	NOUN
arestyrurj-171	99	13	with	with	ADP
arestyrurj-171	99	14	npc-1	npc-1	NOUN
arestyrurj-171	99	15	disease	disease	NOUN
arestyrurj-171	99	16	develop	develop	VERB
arestyrurj-171	99	17	detrimental	detrimental	ADJ
arestyrurj-171	99	18	neurological	neurological	ADJ
arestyrurj-171	99	19	symptoms	symptom	NOUN
arestyrurj-171	99	20	because	because	SCONJ
arestyrurj-171	99	21	their	their	PRON
arestyrurj-171	99	22	cells	cell	NOUN
arestyrurj-171	99	23	accumulate	accumulate	VERB
arestyrurj-171	99	24	cholesterol	cholesterol	NOUN
arestyrurj-171	99	25	in	in	ADP
arestyrurj-171	99	26	the	the	DET
arestyrurj-171	99	27	endolysosomal	endolysosomal	ADJ
arestyrurj-171	99	28	compartment	compartment	NOUN
arestyrurj-171	99	29	and	and	CCONJ
arestyrurj-171	99	30	are	be	AUX
arestyrurj-171	99	31	unable	unable	ADJ
arestyrurj-171	99	32	to	to	PART
arestyrurj-171	99	33	clear	clear	VERB
arestyrurj-171	99	34	the	the	DET
arestyrurj-171	99	35	cholesterol	cholesterol	NOUN
arestyrurj-171	99	36	from	from	ADP
arestyrurj-171	99	37	that	that	DET
arestyrurj-171	99	38	compartment	compartment	NOUN
arestyrurj-171	99	39	.	.	PUNCT
arestyrurj-171	100	1	lbpa	lbpa	PROPN
arestyrurj-171	100	2	clears	clear	VERB
arestyrurj-171	100	3	cholesterol	cholesterol	NOUN
arestyrurj-171	100	4	from	from	ADP
arestyrurj-171	100	5	the	the	DET
arestyrurj-171	100	6	endolysosomal	endolysosomal	ADJ
arestyrurj-171	100	7	compartment	compartment	NOUN
arestyrurj-171	100	8	,	,	PUNCT
arestyrurj-171	100	9	which	which	PRON
arestyrurj-171	100	10	indicates	indicate	VERB
arestyrurj-171	100	11	that	that	SCONJ
arestyrurj-171	100	12	potential	potential	ADJ
arestyrurj-171	100	13	therapies	therapy	NOUN
arestyrurj-171	100	14	to	to	PART
arestyrurj-171	100	15	prevent	prevent	VERB
arestyrurj-171	100	16	the	the	DET
arestyrurj-171	100	17	neurological	neurological	ADJ
arestyrurj-171	100	18	symptoms	symptom	NOUN
arestyrurj-171	100	19	may	may	AUX
arestyrurj-171	100	20	be	be	AUX
arestyrurj-171	100	21	found	find	VERB
arestyrurj-171	100	22	in	in	ADP
arestyrurj-171	100	23	interventions	intervention	NOUN
arestyrurj-171	100	24	that	that	PRON
arestyrurj-171	100	25	increase	increase	VERB
arestyrurj-171	100	26	lbpa	lbpa	NOUN
arestyrurj-171	100	27	,	,	PUNCT
arestyrurj-171	100	28	such	such	ADJ
arestyrurj-171	100	29	as	as	ADP
arestyrurj-171	100	30	pg	pg	PROPN
arestyrurj-171	100	31	treatment	treatment	NOUN
arestyrurj-171	100	32	.	.	PUNCT
arestyrurj-171	101	1	uncovering	uncover	VERB
arestyrurj-171	101	2	the	the	DET
arestyrurj-171	101	3	full	full	ADJ
arestyrurj-171	101	4	process	process	NOUN
arestyrurj-171	101	5	of	of	ADP
arestyrurj-171	101	6	pg	pg	ADV
arestyrurj-171	101	7	-	-	PUNCT
arestyrurj-171	101	8	facilitated	facilitate	VERB
arestyrurj-171	101	9	clearance	clearance	NOUN
arestyrurj-171	101	10	of	of	ADP
arestyrurj-171	101	11	cholesterol	cholesterol	NOUN
arestyrurj-171	101	12	will	will	AUX
arestyrurj-171	101	13	aid	aid	VERB
arestyrurj-171	101	14	in	in	ADP
arestyrurj-171	101	15	manipulating	manipulate	VERB
arestyrurj-171	101	16	lbpa	lbpa	NOUN
arestyrurj-171	101	17	levels	level	NOUN
arestyrurj-171	101	18	for	for	ADP
arestyrurj-171	101	19	potential	potential	ADJ
arestyrurj-171	101	20	therapeutic	therapeutic	ADJ
arestyrurj-171	101	21	benefits	benefit	NOUN
arestyrurj-171	101	22	in	in	ADP
arestyrurj-171	101	23	patients	patient	NOUN
arestyrurj-171	101	24	with	with	ADP
arestyrurj-171	101	25	npc	npc	NOUN
arestyrurj-171	101	26	disease	disease	NOUN
arestyrurj-171	101	27	,	,	PUNCT
arestyrurj-171	101	28	other	other	ADJ
arestyrurj-171	101	29	lysosomal	lysosomal	ADJ
arestyrurj-171	101	30	storage	storage	NOUN
arestyrurj-171	101	31	disorders	disorder	NOUN
arestyrurj-171	101	32	,	,	PUNCT
arestyrurj-171	101	33	and	and	CCONJ
arestyrurj-171	101	34	neurological	neurological	ADJ
arestyrurj-171	101	35	diseases∎	diseases∎	NUM
arestyrurj-171	101	36	5	5	NUM
arestyrurj-171	101	37	references	reference	NOUN
arestyrurj-171	101	38	[	[	X
arestyrurj-171	101	39	1	1	NUM
arestyrurj-171	101	40	]	]	PUNCT
arestyrurj-171	101	41	ballabio	ballabio	VERB
arestyrurj-171	101	42	a	a	PRON
arestyrurj-171	101	43	,	,	PUNCT
arestyrurj-171	101	44	bonifacino	bonifacino	PROPN
arestyrurj-171	101	45	js	js	PROPN
arestyrurj-171	101	46	.	.	PUNCT
arestyrurj-171	102	1	lysosomes	lysosome	NOUN
arestyrurj-171	102	2	as	as	ADP
arestyrurj-171	102	3	dynamic	dynamic	ADJ
arestyrurj-171	102	4	regulators	regulator	NOUN
arestyrurj-171	102	5	of	of	ADP
arestyrurj-171	102	6	cell	cell	NOUN
arestyrurj-171	102	7	and	and	CCONJ
arestyrurj-171	102	8	organismal	organismal	ADJ
arestyrurj-171	102	9	homeostasis	homeostasis	NOUN
arestyrurj-171	102	10	.	.	PUNCT
arestyrurj-171	103	1	nature	nature	NOUN
arestyrurj-171	103	2	reviews	review	VERB
arestyrurj-171	103	3	molecular	molecular	ADJ
arestyrurj-171	103	4	cell	cell	NOUN
arestyrurj-171	103	5	biology	biology	NOUN
arestyrurj-171	103	6	.	.	PUNCT
arestyrurj-171	104	1	2020;21(2):101	2020;21(2):101	PROPN
arestyrurj-171	104	2	-	-	PUNCT
arestyrurj-171	104	3	118	118	NUM
arestyrurj-171	104	4	.	.	PUNCT
arestyrurj-171	105	1	[	[	X
arestyrurj-171	105	2	2	2	NUM
arestyrurj-171	105	3	]	]	X
arestyrurj-171	105	4	berg	berg	PROPN
arestyrurj-171	105	5	to	to	PART
arestyrurj-171	105	6	,	,	PUNCT
arestyrurj-171	105	7	fengsrud	fengsrud	PROPN
arestyrurj-171	105	8	m	m	PROPN
arestyrurj-171	105	9	,	,	PUNCT
arestyrurj-171	105	10	strømhaug	strømhaug	PROPN
arestyrurj-171	105	11	pe	pe	PROPN
arestyrurj-171	105	12	,	,	PUNCT
arestyrurj-171	105	13	berg	berg	PROPN
arestyrurj-171	105	14	t	t	PROPN
arestyrurj-171	105	15	,	,	PUNCT
arestyrurj-171	105	16	seglen	seglen	ADJ
arestyrurj-171	105	17	po	po	NOUN
arestyrurj-171	105	18	.	.	PROPN
arestyrurj-171	105	19	isolation	isolation	NOUN
arestyrurj-171	105	20	and	and	CCONJ
arestyrurj-171	105	21	characterization	characterization	NOUN
arestyrurj-171	105	22	of	of	ADP
arestyrurj-171	105	23	rat	rat	NOUN
arestyrurj-171	105	24	liver	liver	NOUN
arestyrurj-171	105	25	amphisomes	amphisome	NOUN
arestyrurj-171	105	26	.	.	PUNCT
arestyrurj-171	106	1	evidence	evidence	NOUN
arestyrurj-171	106	2	for	for	ADP
arestyrurj-171	106	3	fusion	fusion	NOUN
arestyrurj-171	106	4	of	of	ADP
arestyrurj-171	106	5	autophagosomes	autophagosome	NOUN
arestyrurj-171	106	6	with	with	ADP
arestyrurj-171	106	7	both	both	CCONJ
arestyrurj-171	106	8	early	early	ADJ
arestyrurj-171	106	9	and	and	CCONJ
arestyrurj-171	106	10	late	late	ADJ
arestyrurj-171	106	11	endosomes	endosome	NOUN
arestyrurj-171	106	12	.	.	PUNCT
arestyrurj-171	107	1	the	the	DET
arestyrurj-171	107	2	journal	journal	NOUN
arestyrurj-171	107	3	of	of	ADP
arestyrurj-171	107	4	biological	biological	ADJ
arestyrurj-171	107	5	chemistry	chemistry	NOUN
arestyrurj-171	107	6	.	.	PUNCT
arestyrurj-171	108	1	1998;273(34):21883-	1998;273(34):21883-	X
arestyrurj-171	108	2	.	.	PUNCT
arestyrurj-171	109	1	[	[	X
arestyrurj-171	109	2	3	3	X
arestyrurj-171	109	3	]	]	X
arestyrurj-171	109	4	borbon	borbon	PROPN
arestyrurj-171	109	5	ia	ia	PROPN
arestyrurj-171	109	6	,	,	PUNCT
arestyrurj-171	109	7	erickson	erickson	PROPN
arestyrurj-171	109	8	rp	rp	PROPN
arestyrurj-171	109	9	.	.	PUNCT
arestyrurj-171	109	10	interactions	interaction	NOUN
arestyrurj-171	109	11	of	of	ADP
arestyrurj-171	109	12	npc1	npc1	PROPN
arestyrurj-171	109	13	and	and	CCONJ
arestyrurj-171	109	14	amyloid	amyloid	NOUN
arestyrurj-171	109	15	accumulation	accumulation	NOUN
arestyrurj-171	109	16	/	/	SYM
arestyrurj-171	109	17	deposition	deposition	NOUN
arestyrurj-171	109	18	in	in	ADP
arestyrurj-171	109	19	the	the	DET
arestyrurj-171	109	20	app	app	PROPN
arestyrurj-171	109	21	/	/	SYM
arestyrurj-171	109	22	ps1	ps1	PROPN
arestyrurj-171	109	23	mouse	mouse	NOUN
arestyrurj-171	109	24	model	model	NOUN
arestyrurj-171	109	25	of	of	ADP
arestyrurj-171	109	26	alzheimer	alzheimer	PROPN
arestyrurj-171	109	27	’s	’s	PART
arestyrurj-171	109	28	.	.	PUNCT
arestyrurj-171	110	1	journal	journal	PROPN
arestyrurj-171	110	2	of	of	ADP
arestyrurj-171	110	3	applied	apply	VERB
arestyrurj-171	110	4	genetics	genetic	NOUN
arestyrurj-171	110	5	.	.	PUNCT
arestyrurj-171	111	1	2011;52(2):213	2011;52(2):213	NUM
arestyrurj-171	111	2	-	-	SYM
arestyrurj-171	111	3	218	218	NUM
arestyrurj-171	111	4	.	.	PUNCT
arestyrurj-171	112	1	[	[	X
arestyrurj-171	112	2	4	4	X
arestyrurj-171	112	3	]	]	X
arestyrurj-171	112	4	chan	chan	PROPN
arestyrurj-171	112	5	rb	rb	PROPN
arestyrurj-171	112	6	,	,	PUNCT
arestyrurj-171	112	7	oliveira	oliveira	PROPN
arestyrurj-171	112	8	tg	tg	PROPN
arestyrurj-171	112	9	,	,	PUNCT
arestyrurj-171	112	10	cortes	corte	VERB
arestyrurj-171	112	11	ep	ep	PROPN
arestyrurj-171	112	12	,	,	PUNCT
arestyrurj-171	113	1	et	et	PROPN
arestyrurj-171	113	2	al	al	PROPN
arestyrurj-171	113	3	.	.	PROPN
arestyrurj-171	113	4	comparative	comparative	ADJ
arestyrurj-171	113	5	lipidomic	lipidomic	ADJ
arestyrurj-171	113	6	analysis	analysis	NOUN
arestyrurj-171	113	7	of	of	ADP
arestyrurj-171	113	8	mouse	mouse	NOUN
arestyrurj-171	113	9	and	and	CCONJ
arestyrurj-171	113	10	human	human	ADJ
arestyrurj-171	113	11	brain	brain	NOUN
arestyrurj-171	113	12	with	with	ADP
arestyrurj-171	113	13	alzheimer	alzheimer	PROPN
arestyrurj-171	113	14	disease	disease	PROPN
arestyrurj-171	113	15	.	.	PUNCT
arestyrurj-171	114	1	the	the	DET
arestyrurj-171	114	2	journal	journal	NOUN
arestyrurj-171	114	3	of	of	ADP
arestyrurj-171	114	4	biological	biological	ADJ
arestyrurj-171	114	5	chemistry	chemistry	NOUN
arestyrurj-171	114	6	.	.	PUNCT
arestyrurj-171	115	1	2012;287(4):2678	2012;287(4):2678	NUM
arestyrurj-171	115	2	-	-	SYM
arestyrurj-171	115	3	2688	2688	NUM
arestyrurj-171	115	4	.	.	PUNCT
arestyrurj-171	116	1	[	[	X
arestyrurj-171	116	2	5	5	X
arestyrurj-171	116	3	]	]	X
arestyrurj-171	116	4	chen	chen	PROPN
arestyrurj-171	116	5	y	y	PROPN
arestyrurj-171	116	6	,	,	PUNCT
arestyrurj-171	116	7	klionsky	klionsky	PROPN
arestyrurj-171	116	8	dj	dj	PROPN
arestyrurj-171	116	9	.	.	PUNCT
arestyrurj-171	117	1	the	the	DET
arestyrurj-171	117	2	regulation	regulation	NOUN
arestyrurj-171	117	3	of	of	ADP
arestyrurj-171	117	4	autophagy	autophagy	ADJ
arestyrurj-171	117	5	unanswered	unanswered	ADJ
arestyrurj-171	117	6	questions	question	NOUN
arestyrurj-171	117	7	.	.	PUNCT
arestyrurj-171	118	1	journal	journal	NOUN
arestyrurj-171	118	2	of	of	ADP
arestyrurj-171	118	3	cell	cell	NOUN
arestyrurj-171	118	4	science	science	NOUN
arestyrurj-171	118	5	.	.	PUNCT
arestyrurj-171	119	1	2011;124(pt	2011;124(pt	NUM
arestyrurj-171	119	2	2):161	2):161	NOUN
arestyrurj-171	119	3	-	-	SYM
arestyrurj-171	119	4	170	170	NUM
arestyrurj-171	119	5	.	.	PUNCT
arestyrurj-171	120	1	[	[	X
arestyrurj-171	120	2	6	6	NUM
arestyrurj-171	120	3	]	]	X
arestyrurj-171	120	4	chevallier	chevallier	NOUN
arestyrurj-171	120	5	j	j	PROPN
arestyrurj-171	120	6	,	,	PUNCT
arestyrurj-171	120	7	chamoun	chamoun	PROPN
arestyrurj-171	120	8	z	z	PROPN
arestyrurj-171	120	9	,	,	PUNCT
arestyrurj-171	120	10	jiang	jiang	PROPN
arestyrurj-171	120	11	g	g	PROPN
arestyrurj-171	120	12	,	,	PUNCT
arestyrurj-171	120	13	et	et	PROPN
arestyrurj-171	120	14	al	al	PROPN
arestyrurj-171	120	15	.	.	PROPN
arestyrurj-171	120	16	lysobisphosphatidic	lysobisphosphatidic	PROPN
arestyrurj-171	120	17	acid	acid	PROPN
arestyrurj-171	120	18	controls	control	VERB
arestyrurj-171	120	19	endosomal	endosomal	ADJ
arestyrurj-171	120	20	cholesterol	cholesterol	NOUN
arestyrurj-171	120	21	levels	level	NOUN
arestyrurj-171	120	22	.	.	PUNCT
arestyrurj-171	121	1	the	the	DET
arestyrurj-171	121	2	journal	journal	NOUN
arestyrurj-171	121	3	of	of	ADP
arestyrurj-171	121	4	biological	biological	ADJ
arestyrurj-171	121	5	chemistry	chemistry	NOUN
arestyrurj-171	121	6	.	.	PUNCT
arestyrurj-171	122	1	2008;283(41):27871	2008;283(41):27871	NUM
arestyrurj-171	122	2	-	-	SYM
arestyrurj-171	122	3	27880	27880	NUM
arestyrurj-171	122	4	.	.	PUNCT
arestyrurj-171	123	1	[	[	X
arestyrurj-171	123	2	7	7	X
arestyrurj-171	123	3	]	]	X
arestyrurj-171	123	4	epple	epple	NOUN
arestyrurj-171	123	5	ud	ud	PROPN
arestyrurj-171	123	6	,	,	PUNCT
arestyrurj-171	123	7	suriapranata	suriapranata	VERB
arestyrurj-171	123	8	i	i	PROPN
arestyrurj-171	123	9	,	,	PUNCT
arestyrurj-171	123	10	eskelinen	eskelinen	PROPN
arestyrurj-171	123	11	el	el	PROPN
arestyrurj-171	123	12	,	,	PUNCT
arestyrurj-171	123	13	thumm	thumm	PROPN
arestyrurj-171	123	14	m.	m.	NOUN
arestyrurj-171	123	15	aut5	aut5	PROPN
arestyrurj-171	123	16	/	/	SYM
arestyrurj-171	123	17	cvt17p	cvt17p	PROPN
arestyrurj-171	123	18	,	,	PUNCT
arestyrurj-171	123	19	a	a	DET
arestyrurj-171	123	20	putative	putative	ADJ
arestyrurj-171	123	21	lipase	lipase	NOUN
arestyrurj-171	123	22	essential	essential	ADJ
arestyrurj-171	123	23	for	for	ADP
arestyrurj-171	123	24	disintegration	disintegration	NOUN
arestyrurj-171	123	25	of	of	ADP
arestyrurj-171	123	26	autophagic	autophagic	ADJ
arestyrurj-171	123	27	bodies	body	NOUN
arestyrurj-171	123	28	inside	inside	ADP
arestyrurj-171	123	29	the	the	DET
arestyrurj-171	123	30	vacuole	vacuole	NOUN
arestyrurj-171	123	31	.	.	PUNCT
arestyrurj-171	124	1	journal	journal	PROPN
arestyrurj-171	124	2	of	of	ADP
arestyrurj-171	124	3	bacteriology	bacteriology	NOUN
arestyrurj-171	124	4	.	.	PUNCT
arestyrurj-171	125	1	2001;183(20):5942	2001;183(20):5942	NUM
arestyrurj-171	125	2	-	-	SYM
arestyrurj-171	125	3	5955	5955	NUM
arestyrurj-171	125	4	.	.	PUNCT
arestyrurj-171	126	1	[	[	X
arestyrurj-171	126	2	8	8	NUM
arestyrurj-171	126	3	]	]	PUNCT
arestyrurj-171	126	4	he	he	PRON
arestyrurj-171	126	5	c	c	VERB
arestyrurj-171	126	6	,	,	PUNCT
arestyrurj-171	126	7	klionsky	klionsky	ADJ
arestyrurj-171	126	8	dj	dj	PROPN
arestyrurj-171	126	9	.	.	PUNCT
arestyrurj-171	126	10	regulation	regulation	NOUN
arestyrurj-171	126	11	mechanisms	mechanism	NOUN
arestyrurj-171	126	12	and	and	CCONJ
arestyrurj-171	126	13	signaling	signal	VERB
arestyrurj-171	126	14	pathways	pathway	NOUN
arestyrurj-171	126	15	of	of	ADP
arestyrurj-171	126	16	autophagy	autophagy	NOUN
arestyrurj-171	126	17	.	.	PUNCT
arestyrurj-171	127	1	annual	annual	ADJ
arestyrurj-171	127	2	review	review	NOUN
arestyrurj-171	127	3	of	of	ADP
arestyrurj-171	127	4	genetics	genetic	NOUN
arestyrurj-171	127	5	.	.	PUNCT
arestyrurj-171	128	1	2009;43(1):67	2009;43(1):67	NUM
arestyrurj-171	128	2	-	-	SYM
arestyrurj-171	128	3	93	93	NUM
arestyrurj-171	128	4	.	.	PUNCT
arestyrurj-171	129	1	[	[	X
arestyrurj-171	129	2	9	9	X
arestyrurj-171	129	3	]	]	PUNCT
arestyrurj-171	129	4	hosokawa	hosokawa	NOUN
arestyrurj-171	129	5	n	n	CCONJ
arestyrurj-171	129	6	,	,	PUNCT
arestyrurj-171	129	7	hara	hara	PROPN
arestyrurj-171	129	8	t	t	PROPN
arestyrurj-171	129	9	,	,	PUNCT
arestyrurj-171	129	10	kaizuka	kaizuka	PROPN
arestyrurj-171	129	11	t	t	PROPN
arestyrurj-171	129	12	,	,	PUNCT
arestyrurj-171	129	13	et	et	PROPN
arestyrurj-171	129	14	al	al	PROPN
arestyrurj-171	129	15	.	.	PUNCT
arestyrurj-171	130	1	nutrient	nutrient	NOUN
arestyrurj-171	130	2	-	-	PUNCT
arestyrurj-171	130	3	dependent	dependent	ADJ
arestyrurj-171	130	4	mtorc1	mtorc1	NOUN
arestyrurj-171	130	5	association	association	NOUN
arestyrurj-171	130	6	with	with	ADP
arestyrurj-171	130	7	the	the	DET
arestyrurj-171	130	8	ulk1	ulk1	PROPN
arestyrurj-171	130	9	-	-	PUNCT
arestyrurj-171	130	10	atg13	atg13	PROPN
arestyrurj-171	130	11	-	-	PUNCT
arestyrurj-171	130	12	fip200	fip200	PROPN
arestyrurj-171	130	13	complex	complex	NOUN
arestyrurj-171	130	14	required	require	VERB
arestyrurj-171	130	15	for	for	ADP
arestyrurj-171	130	16	autophagy	autophagy	NOUN
arestyrurj-171	130	17	.	.	PUNCT
arestyrurj-171	131	1	molecular	molecular	ADJ
arestyrurj-171	131	2	biology	biology	NOUN
arestyrurj-171	131	3	of	of	ADP
arestyrurj-171	131	4	the	the	DET
arestyrurj-171	131	5	cell	cell	NOUN
arestyrurj-171	131	6	.	.	PUNCT
arestyrurj-171	132	1	2009;20(7):1981	2009;20(7):1981	NUM
arestyrurj-171	132	2	-	-	SYM
arestyrurj-171	132	3	1991	1991	NUM
arestyrurj-171	132	4	.	.	PUNCT
arestyrurj-171	133	1	[	[	X
arestyrurj-171	133	2	10	10	NUM
arestyrurj-171	133	3	]	]	X
arestyrurj-171	133	4	itakura	itakura	PROPN
arestyrurj-171	133	5	e	e	NOUN
arestyrurj-171	133	6	,	,	PUNCT
arestyrurj-171	133	7	mizushima	mizushima	PROPN
arestyrurj-171	133	8	n.	n.	PROPN
arestyrurj-171	133	9	characterization	characterization	NOUN
arestyrurj-171	133	10	of	of	ADP
arestyrurj-171	133	11	autophagosome	autophagosome	VERB
arestyrurj-171	133	12	formation	formation	NOUN
arestyrurj-171	133	13	site	site	NOUN
arestyrurj-171	133	14	by	by	ADP
arestyrurj-171	133	15	a	a	DET
arestyrurj-171	133	16	hierarchical	hierarchical	ADJ
arestyrurj-171	133	17	analysis	analysis	NOUN
arestyrurj-171	133	18	of	of	ADP
arestyrurj-171	133	19	mammalian	mammalian	ADJ
arestyrurj-171	133	20	atg	atg	PROPN
arestyrurj-171	133	21	proteins	protein	NOUN
arestyrurj-171	133	22	.	.	PUNCT
arestyrurj-171	134	1	autophagy	autophagy	VERB
arestyrurj-171	134	2	.	.	PUNCT
arestyrurj-171	135	1	2010;6(6):764	2010;6(6):764	NUM
arestyrurj-171	135	2	-	-	SYM
arestyrurj-171	135	3	776	776	NUM
arestyrurj-171	135	4	.	.	PUNCT
arestyrurj-171	136	1	[	[	X
arestyrurj-171	136	2	11	11	NUM
arestyrurj-171	136	3	]	]	PUNCT
arestyrurj-171	136	4	kwon	kwon	PROPN
arestyrurj-171	136	5	hj	hj	PROPN
arestyrurj-171	136	6	,	,	PUNCT
arestyrurj-171	136	7	abi	abi	PROPN
arestyrurj-171	136	8	-	-	PUNCT
arestyrurj-171	136	9	mosleh	mosleh	PROPN
arestyrurj-171	136	10	l	l	PROPN
arestyrurj-171	136	11	,	,	PUNCT
arestyrurj-171	136	12	wang	wang	PROPN
arestyrurj-171	136	13	ml	ml	PROPN
arestyrurj-171	136	14	,	,	PUNCT
arestyrurj-171	136	15	et	et	PROPN
arestyrurj-171	136	16	al	al	PROPN
arestyrurj-171	136	17	.	.	PUNCT
arestyrurj-171	136	18	structure	structure	NOUN
arestyrurj-171	136	19	of	of	ADP
arestyrurj-171	136	20	n	n	CCONJ
arestyrurj-171	136	21	-	-	PUNCT
arestyrurj-171	136	22	terminal	terminal	ADJ
arestyrurj-171	136	23	domain	domain	NOUN
arestyrurj-171	136	24	of	of	ADP
arestyrurj-171	136	25	npc1	npc1	PROPN
arestyrurj-171	136	26	reveals	reveal	VERB
arestyrurj-171	136	27	distinct	distinct	ADJ
arestyrurj-171	136	28	subdomains	subdomain	NOUN
arestyrurj-171	136	29	for	for	ADP
arestyrurj-171	136	30	binding	bind	VERB
arestyrurj-171	136	31	and	and	CCONJ
arestyrurj-171	136	32	transfer	transfer	NOUN
arestyrurj-171	136	33	of	of	ADP
arestyrurj-171	136	34	cholesterol	cholesterol	NOUN
arestyrurj-171	136	35	.	.	PUNCT
arestyrurj-171	137	1	cell	cell	NOUN
arestyrurj-171	137	2	.	.	PUNCT
arestyrurj-171	138	1	2009;137(7):12131224	2009;137(7):12131224	NUM
arestyrurj-171	138	2	.	.	PUNCT
arestyrurj-171	139	1	[	[	X
arestyrurj-171	139	2	12	12	NUM
arestyrurj-171	139	3	]	]	X
arestyrurj-171	139	4	li	li	PROPN
arestyrurj-171	139	5	x	x	PROPN
arestyrurj-171	139	6	,	,	PUNCT
arestyrurj-171	139	7	saha	saha	PROPN
arestyrurj-171	139	8	p	p	X
arestyrurj-171	139	9	,	,	PUNCT
arestyrurj-171	139	10	li	li	PROPN
arestyrurj-171	139	11	j	j	PROPN
arestyrurj-171	139	12	,	,	PUNCT
arestyrurj-171	139	13	blobel	blobel	VERB
arestyrurj-171	139	14	g	g	PROPN
arestyrurj-171	139	15	,	,	PUNCT
arestyrurj-171	139	16	pfeffer	pfeffer	PROPN
arestyrurj-171	139	17	sr	sr	PROPN
arestyrurj-171	139	18	.	.	PUNCT
arestyrurj-171	140	1	clues	clue	NOUN
arestyrurj-171	140	2	to	to	ADP
arestyrurj-171	140	3	the	the	DET
arestyrurj-171	140	4	mechanism	mechanism	NOUN
arestyrurj-171	140	5	of	of	ADP
arestyrurj-171	140	6	cholesterol	cholesterol	NOUN
arestyrurj-171	140	7	transfer	transfer	NOUN
arestyrurj-171	140	8	from	from	ADP
arestyrurj-171	140	9	the	the	DET
arestyrurj-171	140	10	structure	structure	NOUN
arestyrurj-171	140	11	of	of	ADP
arestyrurj-171	140	12	npc1	npc1	PROPN
arestyrurj-171	140	13	middle	middle	PROPN
arestyrurj-171	140	14	lumenal	lumenal	ADJ
arestyrurj-171	140	15	domain	domain	NOUN
arestyrurj-171	140	16	bound	bind	VERB
arestyrurj-171	140	17	to	to	PART
arestyrurj-171	140	18	npc2	npc2	VERB
arestyrurj-171	140	19	.	.	PUNCT
arestyrurj-171	141	1	proceedings	proceeding	NOUN
arestyrurj-171	141	2	of	of	ADP
arestyrurj-171	141	3	the	the	DET
arestyrurj-171	141	4	national	national	PROPN
arestyrurj-171	141	5	academy	academy	PROPN
arestyrurj-171	141	6	of	of	ADP
arestyrurj-171	141	7	sciences	sciences	PROPN
arestyrurj-171	141	8	pnas	pnas	PROPN
arestyrurj-171	141	9	.	.	PUNCT
arestyrurj-171	142	1	2016;113(36):1007910084	2016;113(36):1007910084	NUM
arestyrurj-171	142	2	.	.	PUNCT
arestyrurj-171	143	1	[	[	X
arestyrurj-171	143	2	13	13	NUM
arestyrurj-171	143	3	]	]	X
arestyrurj-171	143	4	lieberman	lieberman	PROPN
arestyrurj-171	143	5	ap	ap	PROPN
arestyrurj-171	143	6	,	,	PUNCT
arestyrurj-171	143	7	puertollano	puertollano	NOUN
arestyrurj-171	143	8	r	r	NOUN
arestyrurj-171	143	9	,	,	PUNCT
arestyrurj-171	143	10	raben	raben	VERB
arestyrurj-171	143	11	n	n	PRON
arestyrurj-171	143	12	,	,	PUNCT
arestyrurj-171	143	13	slaugenhaupt	slaugenhaupt	PROPN
arestyrurj-171	143	14	s	s	PROPN
arestyrurj-171	143	15	,	,	PUNCT
arestyrurj-171	143	16	walkley	walkley	PROPN
arestyrurj-171	143	17	su	su	PROPN
arestyrurj-171	143	18	,	,	PUNCT
arestyrurj-171	143	19	ballabio	ballabio	VERB
arestyrurj-171	143	20	a.	a.	NOUN
arestyrurj-171	143	21	autophagy	autophagy	NOUN
arestyrurj-171	143	22	in	in	ADP
arestyrurj-171	143	23	lysosomal	lysosomal	ADJ
arestyrurj-171	143	24	storage	storage	NOUN
arestyrurj-171	143	25	disorders	disorder	NOUN
arestyrurj-171	143	26	.	.	PUNCT
arestyrurj-171	144	1	autophagy	autophagy	VERB
arestyrurj-171	144	2	.	.	PUNCT
arestyrurj-171	145	1	2012;8(5):719	2012;8(5):719	NUM
arestyrurj-171	145	2	-	-	SYM
arestyrurj-171	145	3	730	730	NUM
arestyrurj-171	145	4	.	.	PUNCT
arestyrurj-171	146	1	[	[	X
arestyrurj-171	146	2	14	14	NUM
arestyrurj-171	146	3	]	]	X
arestyrurj-171	146	4	mccauliff	mccauliff	PROPN
arestyrurj-171	146	5	la	la	PROPN
arestyrurj-171	146	6	,	,	PUNCT
arestyrurj-171	146	7	langan	langan	PROPN
arestyrurj-171	146	8	a	a	PROPN
arestyrurj-171	146	9	,	,	PUNCT
arestyrurj-171	146	10	li	li	PROPN
arestyrurj-171	146	11	r	r	PROPN
arestyrurj-171	146	12	,	,	PUNCT
arestyrurj-171	146	13	et	et	PROPN
arestyrurj-171	146	14	al	al	PROPN
arestyrurj-171	146	15	.	.	PROPN
arestyrurj-171	146	16	intracellular	intracellular	ADJ
arestyrurj-171	146	17	cholesterol	cholesterol	NOUN
arestyrurj-171	146	18	trafficking	trafficking	NOUN
arestyrurj-171	146	19	is	be	AUX
arestyrurj-171	146	20	dependent	dependent	ADJ
arestyrurj-171	146	21	upon	upon	SCONJ
arestyrurj-171	146	22	npc2	npc2	ADJ
arestyrurj-171	146	23	interaction	interaction	NOUN
arestyrurj-171	146	24	with	with	ADP
arestyrurj-171	146	25	lysobisphosphatidic	lysobisphosphatidic	ADJ
arestyrurj-171	146	26	acid	acid	NOUN
arestyrurj-171	146	27	.	.	PUNCT
arestyrurj-171	147	1	elife	elife	NOUN
arestyrurj-171	147	2	.	.	PUNCT
arestyrurj-171	148	1	2019;8	2019;8	PROPN
arestyrurj-171	148	2	.	.	PUNCT
arestyrurj-171	149	1	[	[	X
arestyrurj-171	149	2	15	15	NUM
arestyrurj-171	149	3	]	]	X
arestyrurj-171	149	4	mizushima	mizushima	PROPN
arestyrurj-171	149	5	n	n	PROPN
arestyrurj-171	149	6	,	,	PUNCT
arestyrurj-171	149	7	kuma	kuma	PROPN
arestyrurj-171	149	8	a	a	NOUN
arestyrurj-171	149	9	,	,	PUNCT
arestyrurj-171	149	10	kobayashi	kobayashi	PROPN
arestyrurj-171	149	11	y	y	PROPN
arestyrurj-171	149	12	,	,	PUNCT
arestyrurj-171	149	13	et	et	PROPN
arestyrurj-171	149	14	al	al	PROPN
arestyrurj-171	149	15	.	.	PROPN
arestyrurj-171	149	16	mouse	mouse	PROPN
arestyrurj-171	149	17	apg16l	apg16l	PROPN
arestyrurj-171	149	18	,	,	PUNCT
arestyrurj-171	149	19	a	a	DET
arestyrurj-171	149	20	novel	novel	ADJ
arestyrurj-171	149	21	wd	wd	ADJ
arestyrurj-171	149	22	-	-	PUNCT
arestyrurj-171	149	23	repeat	repeat	NOUN
arestyrurj-171	149	24	protein	protein	NOUN
arestyrurj-171	149	25	,	,	PUNCT
arestyrurj-171	149	26	targets	target	NOUN
arestyrurj-171	149	27	to	to	ADP
arestyrurj-171	149	28	the	the	DET
arestyrurj-171	149	29	autophagic	autophagic	ADJ
arestyrurj-171	149	30	isolation	isolation	NOUN
arestyrurj-171	149	31	membrane	membrane	NOUN
arestyrurj-171	149	32	with	with	ADP
arestyrurj-171	149	33	the	the	DET
arestyrurj-171	149	34	apg12	apg12	ADJ
arestyrurj-171	149	35	-	-	PUNCT
arestyrurj-171	149	36	apg5	apg5	PROPN
arestyrurj-171	149	37	conjugate	conjugate	NOUN
arestyrurj-171	149	38	.	.	PUNCT
arestyrurj-171	149	39	journal	journal	NOUN
arestyrurj-171	149	40	of	of	ADP
arestyrurj-171	149	41	cell	cell	NOUN
arestyrurj-171	149	42	science	science	NOUN
arestyrurj-171	149	43	.	.	PUNCT
arestyrurj-171	150	1	2003;116(pt	2003;116(pt	NUM
arestyrurj-171	150	2	9):1679	9):1679	NOUN
arestyrurj-171	150	3	-	-	PUNCT
arestyrurj-171	150	4	1688	1688	NUM
arestyrurj-171	150	5	.	.	PUNCT
arestyrurj-171	151	1	aresty	aresty	ADJ
arestyrurj-171	151	2	rutgers	rutgers	PROPN
arestyrurj-171	151	3	undergraduate	undergraduate	PROPN
arestyrurj-171	151	4	research	research	PROPN
arestyrurj-171	151	5	journal	journal	PROPN
arestyrurj-171	151	6	,	,	PUNCT
arestyrurj-171	151	7	volume	volume	NOUN
arestyrurj-171	151	8	i	i	PRON
arestyrurj-171	151	9	,	,	PUNCT
arestyrurj-171	151	10	issue	issue	VERB
arestyrurj-171	151	11	iii	iii	NOUN
arestyrurj-171	152	1	[	[	X
arestyrurj-171	152	2	16	16	NUM
arestyrurj-171	152	3	]	]	X
arestyrurj-171	152	4	mizushima	mizushima	PROPN
arestyrurj-171	152	5	n	n	PROPN
arestyrurj-171	152	6	,	,	PUNCT
arestyrurj-171	152	7	yamamoto	yamamoto	PROPN
arestyrurj-171	152	8	a	a	PROPN
arestyrurj-171	152	9	,	,	PUNCT
arestyrurj-171	152	10	hatano	hatano	PROPN
arestyrurj-171	152	11	m	m	PROPN
arestyrurj-171	152	12	,	,	PUNCT
arestyrurj-171	152	13	et	et	PROPN
arestyrurj-171	152	14	al	al	PROPN
arestyrurj-171	152	15	.	.	PUNCT
arestyrurj-171	152	16	dissection	dissection	NOUN
arestyrurj-171	152	17	of	of	ADP
arestyrurj-171	152	18	autophagosome	autophagosome	VERB
arestyrurj-171	152	19	formation	formation	NOUN
arestyrurj-171	152	20	using	use	VERB
arestyrurj-171	152	21	apg5	apg5	PROPN
arestyrurj-171	152	22	-	-	PUNCT
arestyrurj-171	152	23	deficient	deficient	ADJ
arestyrurj-171	152	24	mouse	mouse	NOUN
arestyrurj-171	152	25	embryonic	embryonic	ADJ
arestyrurj-171	152	26	stem	stem	NOUN
arestyrurj-171	152	27	cells	cell	NOUN
arestyrurj-171	152	28	.	.	PUNCT
arestyrurj-171	153	1	the	the	DET
arestyrurj-171	153	2	journal	journal	NOUN
arestyrurj-171	153	3	of	of	ADP
arestyrurj-171	153	4	cell	cell	NOUN
arestyrurj-171	153	5	biology	biology	NOUN
arestyrurj-171	153	6	.	.	PUNCT
arestyrurj-171	154	1	2001;152(4):657	2001;152(4):657	NUM
arestyrurj-171	154	2	-	-	SYM
arestyrurj-171	154	3	667	667	NUM
arestyrurj-171	154	4	.	.	PUNCT
arestyrurj-171	155	1	[	[	X
arestyrurj-171	155	2	17	17	NUM
arestyrurj-171	155	3	]	]	SYM
arestyrurj-171	155	4	monastyrska	monastyrska	NOUN
arestyrurj-171	155	5	i	i	NOUN
arestyrurj-171	155	6	,	,	PUNCT
arestyrurj-171	155	7	rieter	rieter	NOUN
arestyrurj-171	155	8	e	e	NOUN
arestyrurj-171	155	9	,	,	PUNCT
arestyrurj-171	155	10	klionsky	klionsky	PROPN
arestyrurj-171	155	11	dj	dj	PROPN
arestyrurj-171	155	12	,	,	PUNCT
arestyrurj-171	155	13	reggiori	reggiori	PROPN
arestyrurj-171	155	14	f.	f.	PROPN
arestyrurj-171	155	15	multiple	multiple	ADJ
arestyrurj-171	155	16	roles	role	NOUN
arestyrurj-171	155	17	of	of	ADP
arestyrurj-171	155	18	the	the	DET
arestyrurj-171	155	19	cytoskeleton	cytoskeleton	NOUN
arestyrurj-171	155	20	in	in	ADP
arestyrurj-171	155	21	autophagy	autophagy	NOUN
arestyrurj-171	155	22	.	.	PUNCT
arestyrurj-171	156	1	biological	biological	ADJ
arestyrurj-171	156	2	reviews	review	NOUN
arestyrurj-171	156	3	of	of	ADP
arestyrurj-171	156	4	the	the	DET
arestyrurj-171	156	5	cambridge	cambridge	PROPN
arestyrurj-171	156	6	philosophical	philosophical	ADJ
arestyrurj-171	156	7	society	society	NOUN
arestyrurj-171	156	8	.	.	PUNCT
arestyrurj-171	157	1	2009;84(3):431	2009;84(3):431	NUM
arestyrurj-171	157	2	-	-	SYM
arestyrurj-171	157	3	448	448	NUM
arestyrurj-171	157	4	.	.	PUNCT
arestyrurj-171	158	1	[	[	X
arestyrurj-171	158	2	18	18	NUM
arestyrurj-171	158	3	]	]	PUNCT
arestyrurj-171	158	4	parzych	parzych	NOUN
arestyrurj-171	158	5	kr	kr	PROPN
arestyrurj-171	158	6	,	,	PUNCT
arestyrurj-171	158	7	klionsky	klionsky	PROPN
arestyrurj-171	158	8	dj	dj	PROPN
arestyrurj-171	158	9	.	.	PUNCT
arestyrurj-171	159	1	an	an	DET
arestyrurj-171	159	2	overview	overview	NOUN
arestyrurj-171	159	3	of	of	ADP
arestyrurj-171	159	4	autophagy	autophagy	NOUN
arestyrurj-171	159	5	:	:	PUNCT
arestyrurj-171	159	6	morphology	morphology	NOUN
arestyrurj-171	159	7	,	,	PUNCT
arestyrurj-171	159	8	mechanism	mechanism	NOUN
arestyrurj-171	159	9	,	,	PUNCT
arestyrurj-171	159	10	and	and	CCONJ
arestyrurj-171	159	11	regulation	regulation	NOUN
arestyrurj-171	159	12	.	.	PUNCT
arestyrurj-171	160	1	antioxid	antioxid	VERB
arestyrurj-171	160	2	redox	redox	NOUN
arestyrurj-171	160	3	signal	signal	NOUN
arestyrurj-171	160	4	.	.	PUNCT
arestyrurj-171	161	1	2014;20(3):460	2014;20(3):460	NUM
arestyrurj-171	161	2	-	-	SYM
arestyrurj-171	161	3	473	473	NUM
arestyrurj-171	161	4	.	.	PUNCT
arestyrurj-171	162	1	[	[	X
arestyrurj-171	162	2	19	19	NUM
arestyrurj-171	162	3	]	]	X
arestyrurj-171	162	4	peake	peake	PROPN
arestyrurj-171	162	5	kb	kb	PROPN
arestyrurj-171	162	6	,	,	PUNCT
arestyrurj-171	162	7	vance	vance	PROPN
arestyrurj-171	162	8	je	je	PROPN
arestyrurj-171	162	9	.	.	PROPN
arestyrurj-171	162	10	defective	defective	ADJ
arestyrurj-171	162	11	cholesterol	cholesterol	NOUN
arestyrurj-171	162	12	trafficking	trafficking	NOUN
arestyrurj-171	162	13	in	in	ADP
arestyrurj-171	162	14	niemann	niemann	PROPN
arestyrurj-171	162	15	-	-	PUNCT
arestyrurj-171	162	16	pick	pick	VERB
arestyrurj-171	162	17	c	c	NOUN
arestyrurj-171	162	18	-	-	PUNCT
arestyrurj-171	162	19	deficient	deficient	ADJ
arestyrurj-171	162	20	cells	cell	NOUN
arestyrurj-171	162	21	.	.	PUNCT
arestyrurj-171	163	1	febs	febs	NOUN
arestyrurj-171	163	2	letters	letter	NOUN
arestyrurj-171	163	3	.	.	PUNCT
arestyrurj-171	164	1	2010;584(13):2731	2010;584(13):2731	NUM
arestyrurj-171	164	2	-	-	SYM
arestyrurj-171	164	3	2739	2739	NUM
arestyrurj-171	164	4	.	.	PUNCT
arestyrurj-171	165	1	[	[	X
arestyrurj-171	165	2	20	20	NUM
arestyrurj-171	165	3	]	]	PUNCT
arestyrurj-171	165	4	pfeffer	pfeffer	PROPN
arestyrurj-171	165	5	sr	sr	PROPN
arestyrurj-171	165	6	.	.	PUNCT
arestyrurj-171	166	1	npc	npc	PROPN
arestyrurj-171	166	2	intracellular	intracellular	ADJ
arestyrurj-171	166	3	cholesterol	cholesterol	NOUN
arestyrurj-171	166	4	transporter	transporter	NOUN
arestyrurj-171	166	5	1	1	NUM
arestyrurj-171	166	6	(	(	PUNCT
arestyrurj-171	166	7	npc1)-mediated	npc1)-mediate	VERB
arestyrurj-171	166	8	cholesterol	cholesterol	NOUN
arestyrurj-171	166	9	export	export	NOUN
arestyrurj-171	166	10	from	from	ADP
arestyrurj-171	166	11	lysosomes	lysosome	NOUN
arestyrurj-171	166	12	.	.	PUNCT
arestyrurj-171	167	1	the	the	DET
arestyrurj-171	167	2	journal	journal	NOUN
arestyrurj-171	167	3	of	of	ADP
arestyrurj-171	167	4	biological	biological	ADJ
arestyrurj-171	167	5	chemistry	chemistry	NOUN
arestyrurj-171	167	6	.	.	PUNCT
arestyrurj-171	168	1	2019;294(5):1706	2019;294(5):1706	NUM
arestyrurj-171	168	2	-	-	SYM
arestyrurj-171	168	3	1709	1709	NUM
arestyrurj-171	168	4	.	.	PUNCT
arestyrurj-171	169	1	[	[	X
arestyrurj-171	169	2	21	21	NUM
arestyrurj-171	169	3	]	]	X
arestyrurj-171	169	4	saftig	saftig	PROPN
arestyrurj-171	169	5	p	p	PROPN
arestyrurj-171	169	6	,	,	PUNCT
arestyrurj-171	169	7	klumperman	klumperman	PROPN
arestyrurj-171	169	8	j.	j.	PROPN
arestyrurj-171	169	9	lysosome	lysosome	PROPN
arestyrurj-171	169	10	biogenesis	biogenesis	NOUN
arestyrurj-171	169	11	and	and	CCONJ
arestyrurj-171	169	12	lysosomal	lysosomal	ADJ
arestyrurj-171	169	13	membrane	membrane	NOUN
arestyrurj-171	169	14	proteins	protein	NOUN
arestyrurj-171	169	15	:	:	PUNCT
arestyrurj-171	169	16	trafficking	traffic	VERB
arestyrurj-171	169	17	meets	meet	VERB
arestyrurj-171	169	18	function	function	NOUN
arestyrurj-171	169	19	.	.	PUNCT
arestyrurj-171	170	1	nature	nature	NOUN
arestyrurj-171	170	2	reviews	review	VERB
arestyrurj-171	170	3	molecular	molecular	ADJ
arestyrurj-171	170	4	cell	cell	NOUN
arestyrurj-171	170	5	biology	biology	NOUN
arestyrurj-171	170	6	.	.	PUNCT
arestyrurj-171	171	1	2009;10(9):623	2009;10(9):623	NUM
arestyrurj-171	171	2	-	-	PUNCT
arestyrurj-171	171	3	635	635	NUM
arestyrurj-171	171	4	.	.	PUNCT
arestyrurj-171	172	1	[	[	X
arestyrurj-171	172	2	22	22	NUM
arestyrurj-171	172	3	]	]	PUNCT
arestyrurj-171	172	4	seranova	seranova	PROPN
arestyrurj-171	172	5	e	e	PROPN
arestyrurj-171	172	6	,	,	PUNCT
arestyrurj-171	172	7	connolly	connolly	PROPN
arestyrurj-171	172	8	kj	kj	PROPN
arestyrurj-171	172	9	,	,	PUNCT
arestyrurj-171	172	10	zatyka	zatyka	PROPN
arestyrurj-171	172	11	m	m	PROPN
arestyrurj-171	172	12	,	,	PUNCT
arestyrurj-171	172	13	et	et	PROPN
arestyrurj-171	172	14	al	al	PROPN
arestyrurj-171	172	15	.	.	PROPN
arestyrurj-171	172	16	dysregulation	dysregulation	NOUN
arestyrurj-171	172	17	of	of	ADP
arestyrurj-171	172	18	autophagy	autophagy	NOUN
arestyrurj-171	172	19	as	as	ADP
arestyrurj-171	172	20	a	a	DET
arestyrurj-171	172	21	common	common	ADJ
arestyrurj-171	172	22	mechanism	mechanism	NOUN
arestyrurj-171	172	23	in	in	ADP
arestyrurj-171	172	24	lysosomal	lysosomal	ADJ
arestyrurj-171	172	25	storage	storage	NOUN
arestyrurj-171	172	26	diseases	disease	NOUN
arestyrurj-171	172	27	.	.	PUNCT
arestyrurj-171	173	1	essays	essay	NOUN
arestyrurj-171	173	2	in	in	ADP
arestyrurj-171	173	3	biochemistry	biochemistry	NOUN
arestyrurj-171	173	4	.	.	PUNCT
arestyrurj-171	174	1	2017;61(6):733	2017;61(6):733	NUM
arestyrurj-171	174	2	-	-	SYM
arestyrurj-171	174	3	749	749	NUM
arestyrurj-171	174	4	.	.	PUNCT
arestyrurj-171	175	1	[	[	X
arestyrurj-171	175	2	23	23	NUM
arestyrurj-171	175	3	]	]	X
arestyrurj-171	175	4	settembre	settembre	PROPN
arestyrurj-171	175	5	c	c	PROPN
arestyrurj-171	175	6	,	,	PUNCT
arestyrurj-171	175	7	fraldi	fraldi	VERB
arestyrurj-171	175	8	a	a	DET
arestyrurj-171	175	9	,	,	PUNCT
arestyrurj-171	175	10	jahreiss	jahreiss	ADJ
arestyrurj-171	175	11	l	l	PROPN
arestyrurj-171	175	12	,	,	PUNCT
arestyrurj-171	175	13	et	et	PROPN
arestyrurj-171	175	14	al	al	PROPN
arestyrurj-171	175	15	.	.	PUNCT
arestyrurj-171	176	1	a	a	DET
arestyrurj-171	176	2	block	block	NOUN
arestyrurj-171	176	3	of	of	ADP
arestyrurj-171	176	4	autophagy	autophagy	NOUN
arestyrurj-171	176	5	in	in	ADP
arestyrurj-171	176	6	lysosomal	lysosomal	ADJ
arestyrurj-171	176	7	storage	storage	NOUN
arestyrurj-171	176	8	disorders	disorder	NOUN
arestyrurj-171	176	9	.	.	PUNCT
arestyrurj-171	177	1	human	human	ADJ
arestyrurj-171	177	2	molecular	molecular	ADJ
arestyrurj-171	177	3	genetics	genetic	NOUN
arestyrurj-171	177	4	.	.	PUNCT
arestyrurj-171	178	1	2008;17(1):119	2008;17(1):119	NUM
arestyrurj-171	178	2	-	-	SYM
arestyrurj-171	178	3	129	129	NUM
arestyrurj-171	178	4	.	.	PUNCT
arestyrurj-171	179	1	[	[	X
arestyrurj-171	179	2	24	24	NUM
arestyrurj-171	179	3	]	]	X
arestyrurj-171	179	4	teter	teter	PROPN
arestyrurj-171	179	5	sa	sa	PROPN
arestyrurj-171	179	6	,	,	PUNCT
arestyrurj-171	179	7	eggerton	eggerton	PROPN
arestyrurj-171	179	8	kp	kp	PROPN
arestyrurj-171	179	9	,	,	PUNCT
arestyrurj-171	179	10	scott	scott	PROPN
arestyrurj-171	179	11	sv	sv	PROPN
arestyrurj-171	179	12	,	,	PUNCT
arestyrurj-171	179	13	kim	kim	PROPN
arestyrurj-171	179	14	j	j	PROPN
arestyrurj-171	179	15	,	,	PUNCT
arestyrurj-171	179	16	fischer	fischer	PROPN
arestyrurj-171	179	17	am	be	AUX
arestyrurj-171	179	18	,	,	PUNCT
arestyrurj-171	179	19	klionsky	klionsky	ADJ
arestyrurj-171	179	20	dj	dj	PROPN
arestyrurj-171	179	21	.	.	PUNCT
arestyrurj-171	180	1	degradation	degradation	NOUN
arestyrurj-171	180	2	of	of	ADP
arestyrurj-171	180	3	lipid	lipid	ADJ
arestyrurj-171	180	4	vesicles	vesicle	NOUN
arestyrurj-171	180	5	in	in	ADP
arestyrurj-171	180	6	the	the	DET
arestyrurj-171	180	7	yeast	yeast	NOUN
arestyrurj-171	180	8	vacuole	vacuole	NOUN
arestyrurj-171	180	9	requires	require	VERB
arestyrurj-171	180	10	function	function	NOUN
arestyrurj-171	180	11	of	of	ADP
arestyrurj-171	180	12	cvt17	cvt17	NOUN
arestyrurj-171	180	13	,	,	PUNCT
arestyrurj-171	180	14	a	a	DET
arestyrurj-171	180	15	putative	putative	ADJ
arestyrurj-171	180	16	lipase	lipase	NOUN
arestyrurj-171	180	17	.	.	PUNCT
arestyrurj-171	181	1	the	the	DET
arestyrurj-171	181	2	journal	journal	NOUN
arestyrurj-171	181	3	of	of	ADP
arestyrurj-171	181	4	biological	biological	ADJ
arestyrurj-171	181	5	chemistry	chemistry	NOUN
arestyrurj-171	181	6	.	.	PUNCT
arestyrurj-171	182	1	2001;276(3):2083	2001;276(3):2083	NUM
arestyrurj-171	182	2	-	-	SYM
arestyrurj-171	182	3	2087	2087	NUM
arestyrurj-171	182	4	.	.	PUNCT
arestyrurj-171	183	1	[	[	X
arestyrurj-171	183	2	25	25	NUM
arestyrurj-171	183	3	]	]	PUNCT
arestyrurj-171	183	4	tooze	tooze	PROPN
arestyrurj-171	183	5	j	j	PROPN
arestyrurj-171	183	6	,	,	PUNCT
arestyrurj-171	183	7	hollinshead	hollinshead	PROPN
arestyrurj-171	183	8	m	m	PROPN
arestyrurj-171	183	9	,	,	PUNCT
arestyrurj-171	183	10	ludwig	ludwig	PROPN
arestyrurj-171	183	11	t	t	PROPN
arestyrurj-171	183	12	,	,	PUNCT
arestyrurj-171	183	13	howell	howell	PROPN
arestyrurj-171	183	14	k	k	PROPN
arestyrurj-171	183	15	,	,	PUNCT
arestyrurj-171	183	16	hoflack	hoflack	NOUN
arestyrurj-171	183	17	b	b	PROPN
arestyrurj-171	183	18	,	,	PUNCT
arestyrurj-171	183	19	kern	kern	PROPN
arestyrurj-171	183	20	h.	h.	PROPN
arestyrurj-171	183	21	in	in	ADP
arestyrurj-171	183	22	exocrine	exocrine	NOUN
arestyrurj-171	183	23	pancreas	pancrea	NOUN
arestyrurj-171	183	24	,	,	PUNCT
arestyrurj-171	183	25	the	the	DET
arestyrurj-171	183	26	basolateral	basolateral	ADJ
arestyrurj-171	183	27	endocytic	endocytic	ADJ
arestyrurj-171	183	28	pathway	pathway	NOUN
arestyrurj-171	183	29	converges	converge	VERB
arestyrurj-171	183	30	with	with	ADP
arestyrurj-171	183	31	the	the	DET
arestyrurj-171	183	32	autophagic	autophagic	ADJ
arestyrurj-171	183	33	pathway	pathway	NOUN
arestyrurj-171	183	34	immediately	immediately	ADV
arestyrurj-171	183	35	after	after	ADP
arestyrurj-171	183	36	the	the	DET
arestyrurj-171	183	37	early	early	ADJ
arestyrurj-171	183	38	endosome	endosome	NOUN
arestyrurj-171	183	39	.	.	PUNCT
arestyrurj-171	184	1	j	j	PROPN
arestyrurj-171	184	2	cell	cell	PROPN
arestyrurj-171	184	3	biol	biol	PROPN
arestyrurj-171	184	4	.	.	PUNCT
arestyrurj-171	185	1	1990	1990	NUM
arestyrurj-171	185	2	aug;111(2):329	aug;111(2):329	NOUN
arestyrurj-171	185	3	-	-	SYM
arestyrurj-171	185	4	45	45	NUM
arestyrurj-171	185	5	.	.	PUNCT
arestyrurj-171	186	1	[	[	X
arestyrurj-171	186	2	26	26	NUM
arestyrurj-171	186	3	]	]	X
arestyrurj-171	186	4	vanier	vanier	NOUN
arestyrurj-171	186	5	m	m	PROPN
arestyrurj-171	186	6	,	,	PUNCT
arestyrurj-171	186	7	millat	millat	PROPN
arestyrurj-171	186	8	g.	g.	PROPN
arestyrurj-171	186	9	niemann	niemann	PROPN
arestyrurj-171	186	10	-	-	PUNCT
arestyrurj-171	186	11	pick	pick	PROPN
arestyrurj-171	186	12	disease	disease	NOUN
arestyrurj-171	186	13	type	type	NOUN
arestyrurj-171	186	14	c.	c.	PROPN
arestyrurj-171	186	15	clinical	clinical	ADJ
arestyrurj-171	186	16	genetics	genetic	NOUN
arestyrurj-171	186	17	.	.	PUNCT
arestyrurj-171	187	1	2003;64(4):269	2003;64(4):269	NUM
arestyrurj-171	187	2	-	-	PUNCT
arestyrurj-171	187	3	281	281	NUM
arestyrurj-171	187	4	.	.	PUNCT
arestyrurj-171	188	1	[	[	X
arestyrurj-171	188	2	27	27	NUM
arestyrurj-171	188	3	]	]	X
arestyrurj-171	188	4	yim	yim	PROPN
arestyrurj-171	188	5	ww	ww	PROPN
arestyrurj-171	188	6	-	-	PROPN
arestyrurj-171	188	7	y	y	PROPN
arestyrurj-171	188	8	,	,	PUNCT
arestyrurj-171	188	9	mizushima	mizushima	PROPN
arestyrurj-171	188	10	n.	n.	PROPN
arestyrurj-171	188	11	lysosome	lysosome	PROPN
arestyrurj-171	188	12	biology	biology	NOUN
arestyrurj-171	188	13	in	in	ADP
arestyrurj-171	188	14	autophagy	autophagy	NOUN
arestyrurj-171	188	15	.	.	PUNCT
arestyrurj-171	189	1	cell	cell	NOUN
arestyrurj-171	189	2	discovery	discovery	NOUN
arestyrurj-171	189	3	.	.	PUNCT
arestyrurj-171	190	1	2020;6(1):6	2020;6(1):6	PROPN
arestyrurj-171	190	2	-	-	PUNCT
arestyrurj-171	190	3	6	6	NUM
arestyrurj-171	190	4	.	.	PUNCT
arestyrurj-171	191	1	[	[	X
arestyrurj-171	191	2	28	28	NUM
arestyrurj-171	191	3	]	]	X
arestyrurj-171	191	4	yorimitsu	yorimitsu	PROPN
arestyrurj-171	191	5	t	t	PROPN
arestyrurj-171	191	6	,	,	PUNCT
arestyrurj-171	191	7	klionsky	klionsky	PROPN
arestyrurj-171	191	8	dj	dj	PROPN
arestyrurj-171	191	9	.	.	PUNCT
arestyrurj-171	192	1	autophagy	autophagy	NOUN
arestyrurj-171	192	2	:	:	PUNCT
arestyrurj-171	192	3	molecular	molecular	ADJ
arestyrurj-171	192	4	machinery	machinery	NOUN
arestyrurj-171	192	5	for	for	ADP
arestyrurj-171	192	6	self	self	NOUN
arestyrurj-171	192	7	-	-	PUNCT
arestyrurj-171	192	8	eating	eat	VERB
arestyrurj-171	192	9	.	.	PUNCT
arestyrurj-171	193	1	cell	cell	NOUN
arestyrurj-171	193	2	death	death	NOUN
arestyrurj-171	193	3	and	and	CCONJ
arestyrurj-171	193	4	differentiation	differentiation	NOUN
arestyrurj-171	193	5	.	.	PUNCT
arestyrurj-171	194	1	2005;12(s2):1542	2005;12(s2):1542	NUM
arestyrurj-171	194	2	-	-	SYM
arestyrurj-171	194	3	1552	1552	NUM
arestyrurj-171	194	4	.	.	PUNCT
arestyrurj-171	195	1	[	[	X
arestyrurj-171	195	2	29	29	NUM
arestyrurj-171	195	3	]	]	PUNCT
arestyrurj-171	195	4	xu	xu	PROPN
arestyrurj-171	195	5	h	h	PROPN
arestyrurj-171	195	6	,	,	PUNCT
arestyrurj-171	195	7	ren	ren	PROPN
arestyrurj-171	195	8	d.	d.	PROPN
arestyrurj-171	195	9	lysosomal	lysosomal	PROPN
arestyrurj-171	195	10	physiology	physiology	NOUN
arestyrurj-171	195	11	.	.	PUNCT
arestyrurj-171	196	1	annual	annual	ADJ
arestyrurj-171	196	2	review	review	NOUN
arestyrurj-171	196	3	of	of	ADP
arestyrurj-171	196	4	physiology	physiology	NOUN
arestyrurj-171	196	5	.	.	PUNCT
arestyrurj-171	197	1	2015;77(1):57	2015;77(1):57	NUM
arestyrurj-171	197	2	-	-	SYM
arestyrurj-171	197	3	80	80	NUM
arestyrurj-171	197	4	.	.	PUNCT
arestyrurj-171	198	1	my	my	PRON
arestyrurj-171	198	2	name	name	NOUN
arestyrurj-171	198	3	is	be	AUX
arestyrurj-171	198	4	tamara	tamara	PROPN
arestyrurj-171	198	5	allada	allada	PROPN
arestyrurj-171	198	6	and	and	CCONJ
arestyrurj-171	198	7	i	i	PRON
arestyrurj-171	198	8	am	be	AUX
arestyrurj-171	198	9	a	a	DET
arestyrurj-171	198	10	2021	2021	NUM
arestyrurj-171	198	11	rutgers	rutger	NOUN
arestyrurj-171	198	12	graduate	graduate	NOUN
arestyrurj-171	198	13	and	and	CCONJ
arestyrurj-171	198	14	the	the	DET
arestyrurj-171	198	15	main	main	ADJ
arestyrurj-171	198	16	author	author	NOUN
arestyrurj-171	198	17	of	of	ADP
arestyrurj-171	198	18	this	this	DET
arestyrurj-171	198	19	paper	paper	NOUN
arestyrurj-171	198	20	.	.	PUNCT
arestyrurj-171	199	1	i	i	PRON
arestyrurj-171	199	2	spent	spend	VERB
arestyrurj-171	199	3	my	my	PRON
arestyrurj-171	199	4	final	final	ADJ
arestyrurj-171	199	5	two	two	NUM
arestyrurj-171	199	6	years	year	NOUN
arestyrurj-171	199	7	of	of	ADP
arestyrurj-171	199	8	college	college	NOUN
arestyrurj-171	199	9	working	work	VERB
arestyrurj-171	199	10	with	with	ADP
arestyrurj-171	199	11	dr	dr	PROPN
arestyrurj-171	199	12	.	.	PROPN
arestyrurj-171	199	13	judith	judith	PROPN
arestyrurj-171	199	14	storch	storch	PROPN
arestyrurj-171	199	15	and	and	CCONJ
arestyrurj-171	199	16	dr	dr	PROPN
arestyrurj-171	199	17	.	.	PROPN
arestyrurj-171	199	18	olga	olga	PROPN
arestyrurj-171	199	19	ilnytska	ilnytska	PROPN
arestyrurj-171	199	20	in	in	ADP
arestyrurj-171	199	21	the	the	DET
arestyrurj-171	199	22	rutgers	rutgers	PROPN
arestyrurj-171	199	23	department	department	PROPN
arestyrurj-171	199	24	of	of	ADP
arestyrurj-171	199	25	nutritional	nutritional	ADJ
arestyrurj-171	199	26	sciences	science	NOUN
arestyrurj-171	199	27	.	.	PUNCT
arestyrurj-171	200	1	our	our	PRON
arestyrurj-171	200	2	lab	lab	NOUN
arestyrurj-171	200	3	's	's	PART
arestyrurj-171	200	4	main	main	ADJ
arestyrurj-171	200	5	area	area	NOUN
arestyrurj-171	200	6	of	of	ADP
arestyrurj-171	200	7	study	study	NOUN
arestyrurj-171	200	8	is	be	AUX
arestyrurj-171	200	9	the	the	DET
arestyrurj-171	200	10	method	method	NOUN
arestyrurj-171	200	11	of	of	ADP
arestyrurj-171	200	12	intracellular	intracellular	ADJ
arestyrurj-171	200	13	cholesterol	cholesterol	NOUN
arestyrurj-171	200	14	transport	transport	NOUN
arestyrurj-171	200	15	,	,	PUNCT
arestyrurj-171	200	16	as	as	SCONJ
arestyrurj-171	200	17	the	the	DET
arestyrurj-171	200	18	exact	exact	ADJ
arestyrurj-171	200	19	pathway	pathway	NOUN
arestyrurj-171	200	20	in	in	ADP
arestyrurj-171	200	21	which	which	PRON
arestyrurj-171	200	22	cholesterol	cholesterol	NOUN
arestyrurj-171	200	23	is	be	AUX
arestyrurj-171	200	24	trafficked	traffic	VERB
arestyrurj-171	200	25	through	through	ADP
arestyrurj-171	200	26	a	a	DET
arestyrurj-171	200	27	cell	cell	NOUN
arestyrurj-171	200	28	is	be	AUX
arestyrurj-171	200	29	currently	currently	ADV
arestyrurj-171	200	30	unknown	unknown	ADJ
arestyrurj-171	200	31	.	.	PUNCT
arestyrurj-171	201	1	there	there	PRON
arestyrurj-171	201	2	are	be	VERB
arestyrurj-171	201	3	many	many	ADJ
arestyrurj-171	201	4	lysosomal	lysosomal	ADJ
arestyrurj-171	201	5	storage	storage	NOUN
arestyrurj-171	201	6	disorders	disorder	NOUN
arestyrurj-171	201	7	,	,	PUNCT
arestyrurj-171	201	8	such	such	ADJ
arestyrurj-171	201	9	as	as	ADP
arestyrurj-171	201	10	niemman	niemman	NOUN
arestyrurj-171	201	11	pick	pick	VERB
arestyrurj-171	201	12	c	c	PROPN
arestyrurj-171	201	13	disease	disease	NOUN
arestyrurj-171	201	14	,	,	PUNCT
arestyrurj-171	201	15	that	that	PRON
arestyrurj-171	201	16	cause	cause	VERB
arestyrurj-171	201	17	cholesterol	cholesterol	NOUN
arestyrurj-171	201	18	to	to	PART
arestyrurj-171	201	19	become	become	VERB
arestyrurj-171	201	20	trapped	trapped	ADJ
arestyrurj-171	201	21	in	in	ADP
arestyrurj-171	201	22	a	a	DET
arestyrurj-171	201	23	compartment	compartment	NOUN
arestyrurj-171	201	24	of	of	ADP
arestyrurj-171	201	25	the	the	DET
arestyrurj-171	201	26	cell	cell	NOUN
arestyrurj-171	201	27	and	and	CCONJ
arestyrurj-171	201	28	unable	unable	ADJ
arestyrurj-171	201	29	to	to	PART
arestyrurj-171	201	30	be	be	AUX
arestyrurj-171	201	31	trafficked	traffic	VERB
arestyrurj-171	201	32	,	,	PUNCT
arestyrurj-171	201	33	resulting	result	VERB
arestyrurj-171	201	34	in	in	ADP
arestyrurj-171	201	35	severe	severe	ADJ
arestyrurj-171	201	36	neurological	neurological	ADJ
arestyrurj-171	201	37	defects	defect	NOUN
arestyrurj-171	201	38	.	.	PUNCT
arestyrurj-171	202	1	knowing	know	VERB
arestyrurj-171	202	2	the	the	DET
arestyrurj-171	202	3	exact	exact	ADJ
arestyrurj-171	202	4	pathway	pathway	NOUN
arestyrurj-171	202	5	of	of	ADP
arestyrurj-171	202	6	intracellular	intracellular	ADJ
arestyrurj-171	202	7	cholesterol	cholesterol	NOUN
arestyrurj-171	202	8	transport	transport	NOUN
arestyrurj-171	202	9	would	would	AUX
arestyrurj-171	202	10	aid	aid	VERB
arestyrurj-171	202	11	greatly	greatly	ADV
arestyrurj-171	202	12	in	in	ADP
arestyrurj-171	202	13	the	the	DET
arestyrurj-171	202	14	search	search	NOUN
arestyrurj-171	202	15	for	for	ADP
arestyrurj-171	202	16	a	a	DET
arestyrurj-171	202	17	treatment	treatment	NOUN
arestyrurj-171	202	18	to	to	ADP
arestyrurj-171	202	19	such	such	ADJ
arestyrurj-171	202	20	disorders	disorder	NOUN
arestyrurj-171	202	21	.	.	PUNCT