id	sid	tid	token	lemma	pos
arestyrurj-207	1	1	aresty	aresty	PROPN
arestyrurj-207	1	2	rutgers	rutgers	PROPN
arestyrurj-207	1	3	undergraduate	undergraduate	PROPN
arestyrurj-207	1	4	research	research	PROPN
arestyrurj-207	1	5	journal	journal	PROPN
arestyrurj-207	1	6	,	,	PUNCT
arestyrurj-207	1	7	volume	volume	NOUN
arestyrurj-207	1	8	i	i	PRON
arestyrurj-207	1	9	,	,	PUNCT
arestyrurj-207	1	10	issue	issue	NOUN
arestyrurj-207	1	11	iv	iv	NUM
arestyrurj-207	1	12	this	this	DET
arestyrurj-207	1	13	work	work	NOUN
arestyrurj-207	1	14	is	be	AUX
arestyrurj-207	1	15	licensed	license	VERB
arestyrurj-207	1	16	under	under	ADP
arestyrurj-207	1	17	a	a	DET
arestyrurj-207	1	18	creative	creative	ADJ
arestyrurj-207	1	19	commons	common	NOUN
arestyrurj-207	1	20	attribution	attribution	NOUN
arestyrurj-207	1	21	-	-	PUNCT
arestyrurj-207	1	22	noncommercial	noncommercial	ADJ
arestyrurj-207	1	23	-	-	PUNCT
arestyrurj-207	1	24	sharealike	sharealike	ADJ
arestyrurj-207	1	25	4.0	4.0	NUM
arestyrurj-207	1	26	international	international	ADJ
arestyrurj-207	1	27	license	license	NOUN
arestyrurj-207	1	28	.	.	PUNCT
arestyrurj-207	2	1	exploring	explore	VERB
arestyrurj-207	2	2	epithelial	epithelial	ADJ
arestyrurj-207	2	3	communication	communication	NOUN
arestyrurj-207	2	4	to	to	ADP
arestyrurj-207	2	5	the	the	DET
arestyrurj-207	2	6	mesenchyme	mesenchyme	NOUN
arestyrurj-207	2	7	and	and	CCONJ
arestyrurj-207	2	8	its	its	PRON
arestyrurj-207	2	9	impact	impact	NOUN
arestyrurj-207	2	10	on	on	ADP
arestyrurj-207	2	11	the	the	DET
arestyrurj-207	2	12	expression	expression	NOUN
arestyrurj-207	2	13	of	of	ADP
arestyrurj-207	2	14	genes	gene	NOUN
arestyrurj-207	2	15	related	relate	VERB
arestyrurj-207	2	16	to	to	ADP
arestyrurj-207	2	17	tumorigenesis	tumorigenesis	NOUN
arestyrurj-207	2	18	jay	jay	PROPN
arestyrurj-207	2	19	patel	patel	PROPN
arestyrurj-207	2	20	,	,	PUNCT
arestyrurj-207	2	21	michael	michael	PROPN
arestyrurj-207	2	22	verzi	verzi	PROPN
arestyrurj-207	2	23	(	(	PUNCT
arestyrurj-207	2	24	faculty	faculty	NOUN
arestyrurj-207	2	25	advisor	advisor	NOUN
arestyrurj-207	2	26	)	)	PUNCT
arestyrurj-207	2	27	✵	✵	NOUN
arestyrurj-207	2	28	abstract	abstract	ADJ
arestyrurj-207	2	29	homeostasis	homeostasis	NOUN
arestyrurj-207	2	30	of	of	ADP
arestyrurj-207	2	31	the	the	DET
arestyrurj-207	2	32	epithelium	epithelium	NOUN
arestyrurj-207	2	33	is	be	AUX
arestyrurj-207	2	34	dependent	dependent	ADJ
arestyrurj-207	2	35	on	on	ADP
arestyrurj-207	2	36	the	the	DET
arestyrurj-207	2	37	wnt	wnt	PROPN
arestyrurj-207	2	38	/	/	SYM
arestyrurj-207	2	39	beta	beta	NOUN
arestyrurj-207	2	40	-	-	PUNCT
arestyrurj-207	2	41	catenin	catenin	NOUN
arestyrurj-207	2	42	pathway	pathway	NOUN
arestyrurj-207	2	43	,	,	PUNCT
arestyrurj-207	2	44	which	which	PRON
arestyrurj-207	2	45	regulates	regulate	VERB
arestyrurj-207	2	46	the	the	DET
arestyrurj-207	2	47	proliferation	proliferation	NOUN
arestyrurj-207	2	48	of	of	ADP
arestyrurj-207	2	49	intestinal	intestinal	ADJ
arestyrurj-207	2	50	stem	stem	NOUN
arestyrurj-207	2	51	cells	cell	NOUN
arestyrurj-207	2	52	.	.	PUNCT
arestyrurj-207	3	1	the	the	DET
arestyrurj-207	3	2	gain	gain	NOUN
arestyrurj-207	3	3	of	of	ADP
arestyrurj-207	3	4	function	function	NOUN
arestyrurj-207	3	5	mutations	mutation	NOUN
arestyrurj-207	3	6	in	in	ADP
arestyrurj-207	3	7	the	the	DET
arestyrurj-207	3	8	beta	beta	NOUN
arestyrurj-207	3	9	-	-	PUNCT
arestyrurj-207	3	10	catenin	catenin	NOUN
arestyrurj-207	3	11	gene	gene	NOUN
arestyrurj-207	3	12	leads	lead	VERB
arestyrurj-207	3	13	to	to	ADP
arestyrurj-207	3	14	rapid	rapid	ADJ
arestyrurj-207	3	15	cell	cell	NOUN
arestyrurj-207	3	16	proliferation	proliferation	NOUN
arestyrurj-207	3	17	and	and	CCONJ
arestyrurj-207	3	18	malignant	malignant	ADJ
arestyrurj-207	3	19	growth	growth	NOUN
arestyrurj-207	3	20	in	in	ADP
arestyrurj-207	3	21	the	the	DET
arestyrurj-207	3	22	epithelium	epithelium	NOUN
arestyrurj-207	3	23	.	.	PUNCT
arestyrurj-207	4	1	in	in	ADP
arestyrurj-207	4	2	addition	addition	NOUN
arestyrurj-207	4	3	,	,	PUNCT
arestyrurj-207	4	4	the	the	DET
arestyrurj-207	4	5	maintenance	maintenance	NOUN
arestyrurj-207	4	6	of	of	ADP
arestyrurj-207	4	7	these	these	DET
arestyrurj-207	4	8	stem	stem	NOUN
arestyrurj-207	4	9	cells	cell	NOUN
arestyrurj-207	4	10	appears	appear	VERB
arestyrurj-207	4	11	to	to	PART
arestyrurj-207	4	12	be	be	AUX
arestyrurj-207	4	13	linked	link	VERB
arestyrurj-207	4	14	to	to	ADP
arestyrurj-207	4	15	mesenchymal	mesenchymal	NOUN
arestyrurj-207	4	16	-	-	PUNCT
arestyrurj-207	4	17	derived	derive	VERB
arestyrurj-207	4	18	factors	factor	NOUN
arestyrurj-207	4	19	.	.	PUNCT
arestyrurj-207	5	1	although	although	SCONJ
arestyrurj-207	5	2	the	the	DET
arestyrurj-207	5	3	communication	communication	NOUN
arestyrurj-207	5	4	between	between	ADP
arestyrurj-207	5	5	epithelial	epithelial	ADJ
arestyrurj-207	5	6	and	and	CCONJ
arestyrurj-207	5	7	mesenchyme	mesenchyme	NOUN
arestyrurj-207	5	8	cell	cell	NOUN
arestyrurj-207	5	9	populations	population	NOUN
arestyrurj-207	5	10	remains	remain	VERB
arestyrurj-207	5	11	uncharacterized	uncharacterized	ADJ
arestyrurj-207	5	12	,	,	PUNCT
arestyrurj-207	5	13	understanding	understand	VERB
arestyrurj-207	5	14	this	this	DET
arestyrurj-207	5	15	mechanism	mechanism	NOUN
arestyrurj-207	5	16	will	will	AUX
arestyrurj-207	5	17	help	help	VERB
arestyrurj-207	5	18	us	we	PRON
arestyrurj-207	5	19	further	far	ADV
arestyrurj-207	5	20	understand	understand	VERB
arestyrurj-207	5	21	the	the	DET
arestyrurj-207	5	22	various	various	ADJ
arestyrurj-207	5	23	pathways	pathway	NOUN
arestyrurj-207	5	24	involved	involve	VERB
arestyrurj-207	5	25	in	in	ADP
arestyrurj-207	5	26	tumor	tumor	NOUN
arestyrurj-207	5	27	initiation	initiation	NOUN
arestyrurj-207	5	28	processes	process	NOUN
arestyrurj-207	5	29	.	.	PUNCT
arestyrurj-207	6	1	our	our	PRON
arestyrurj-207	6	2	results	result	NOUN
arestyrurj-207	6	3	show	show	VERB
arestyrurj-207	6	4	that	that	SCONJ
arestyrurj-207	6	5	the	the	DET
arestyrurj-207	6	6	communication	communication	NOUN
arestyrurj-207	6	7	between	between	ADP
arestyrurj-207	6	8	the	the	DET
arestyrurj-207	6	9	mesenchyme	mesenchyme	NOUN
arestyrurj-207	6	10	and	and	CCONJ
arestyrurj-207	6	11	epithelium	epithelium	NOUN
arestyrurj-207	6	12	during	during	ADP
arestyrurj-207	6	13	transformation	transformation	NOUN
arestyrurj-207	6	14	is	be	AUX
arestyrurj-207	6	15	influenced	influence	VERB
arestyrurj-207	6	16	by	by	ADP
arestyrurj-207	6	17	varying	vary	VERB
arestyrurj-207	6	18	levels	level	NOUN
arestyrurj-207	6	19	of	of	ADP
arestyrurj-207	6	20	protein	protein	NOUN
arestyrurj-207	6	21	-	-	PUNCT
arestyrurj-207	6	22	expressing	express	VERB
arestyrurj-207	6	23	genes	gene	NOUN
arestyrurj-207	6	24	including	include	VERB
arestyrurj-207	6	25	wnt2b	wnt2b	PROPN
arestyrurj-207	6	26	,	,	PUNCT
arestyrurj-207	6	27	grem1	grem1	NOUN
arestyrurj-207	6	28	,	,	PUNCT
arestyrurj-207	6	29	and	and	CCONJ
arestyrurj-207	6	30	bmp6	bmp6	NOUN
arestyrurj-207	6	31	.	.	PUNCT
arestyrurj-207	7	1	1	1	NUM
arestyrurj-207	7	2	introduction	introduction	NOUN
arestyrurj-207	7	3	the	the	DET
arestyrurj-207	7	4	wnt	wnt	PROPN
arestyrurj-207	7	5	/	/	SYM
arestyrurj-207	7	6	beta	beta	NOUN
arestyrurj-207	7	7	-	-	PUNCT
arestyrurj-207	7	8	catenin	catenin	NOUN
arestyrurj-207	7	9	pathway	pathway	NOUN
arestyrurj-207	7	10	regulates	regulate	VERB
arestyrurj-207	7	11	the	the	DET
arestyrurj-207	7	12	transcription	transcription	NOUN
arestyrurj-207	7	13	of	of	ADP
arestyrurj-207	7	14	wnt	wnt	PROPN
arestyrurj-207	7	15	target	target	NOUN
arestyrurj-207	7	16	genes	gene	NOUN
arestyrurj-207	7	17	—	—	PUNCT
arestyrurj-207	7	18	genes	gene	NOUN
arestyrurj-207	7	19	which	which	PRON
arestyrurj-207	7	20	are	be	AUX
arestyrurj-207	7	21	highly	highly	ADV
arestyrurj-207	7	22	deregulated	deregulated	ADJ
arestyrurj-207	7	23	in	in	ADP
arestyrurj-207	7	24	solid	solid	ADJ
arestyrurj-207	7	25	tumors	tumor	NOUN
arestyrurj-207	7	26	(	(	PUNCT
arestyrurj-207	7	27	fevr	fevr	PROPN
arestyrurj-207	7	28	et	et	PROPN
arestyrurj-207	7	29	al	al	PROPN
arestyrurj-207	7	30	.	.	PROPN
arestyrurj-207	7	31	,	,	PUNCT
arestyrurj-207	7	32	2007	2007	NUM
arestyrurj-207	7	33	)	)	PUNCT
arestyrurj-207	7	34	.	.	PUNCT
arestyrurj-207	8	1	in	in	ADP
arestyrurj-207	8	2	the	the	DET
arestyrurj-207	8	3	absence	absence	NOUN
arestyrurj-207	8	4	of	of	ADP
arestyrurj-207	8	5	the	the	DET
arestyrurj-207	8	6	wnt	wnt	PROPN
arestyrurj-207	8	7	ligand	ligand	PROPN
arestyrurj-207	8	8	,	,	PUNCT
arestyrurj-207	8	9	betacatenin	betacatenin	NOUN
arestyrurj-207	8	10	,	,	PUNCT
arestyrurj-207	8	11	a	a	DET
arestyrurj-207	8	12	protein	protein	NOUN
arestyrurj-207	8	13	normally	normally	ADV
arestyrurj-207	8	14	sequestered	sequester	VERB
arestyrurj-207	8	15	in	in	ADP
arestyrurj-207	8	16	the	the	DET
arestyrurj-207	8	17	cytoplasm	cytoplasm	NOUN
arestyrurj-207	8	18	,	,	PUNCT
arestyrurj-207	8	19	is	be	AUX
arestyrurj-207	8	20	constantly	constantly	ADV
arestyrurj-207	8	21	degraded	degrade	VERB
arestyrurj-207	8	22	and	and	CCONJ
arestyrurj-207	8	23	is	be	AUX
arestyrurj-207	8	24	prevented	prevent	VERB
arestyrurj-207	8	25	from	from	ADP
arestyrurj-207	8	26	entering	enter	VERB
arestyrurj-207	8	27	the	the	DET
arestyrurj-207	8	28	nucleus	nucleus	NOUN
arestyrurj-207	8	29	.	.	PUNCT
arestyrurj-207	9	1	in	in	ADP
arestyrurj-207	9	2	the	the	DET
arestyrurj-207	9	3	presence	presence	NOUN
arestyrurj-207	9	4	of	of	ADP
arestyrurj-207	9	5	the	the	DET
arestyrurj-207	9	6	wnt	wnt	PROPN
arestyrurj-207	9	7	ligand	ligand	PROPN
arestyrurj-207	9	8	,	,	PUNCT
arestyrurj-207	9	9	wnt	wnt	PROPN
arestyrurj-207	9	10	is	be	AUX
arestyrurj-207	9	11	able	able	ADJ
arestyrurj-207	9	12	to	to	PART
arestyrurj-207	9	13	bind	bind	VERB
arestyrurj-207	9	14	to	to	ADP
arestyrurj-207	9	15	its	its	PRON
arestyrurj-207	9	16	receptor	receptor	NOUN
arestyrurj-207	9	17	frizzled	frizzle	VERB
arestyrurj-207	9	18	,	,	PUNCT
arestyrurj-207	9	19	which	which	PRON
arestyrurj-207	9	20	activates	activate	VERB
arestyrurj-207	9	21	downstream	downstream	ADJ
arestyrurj-207	9	22	signaling	signal	VERB
arestyrurj-207	9	23	and	and	CCONJ
arestyrurj-207	9	24	prevents	prevent	VERB
arestyrurj-207	9	25	the	the	DET
arestyrurj-207	9	26	destruction	destruction	NOUN
arestyrurj-207	9	27	of	of	ADP
arestyrurj-207	9	28	beta	beta	NOUN
arestyrurj-207	9	29	-	-	PUNCT
arestyrurj-207	9	30	catenin	catenin	NOUN
arestyrurj-207	9	31	,	,	PUNCT
arestyrurj-207	9	32	thus	thus	ADV
arestyrurj-207	9	33	enabling	enable	VERB
arestyrurj-207	9	34	its	its	PRON
arestyrurj-207	9	35	entry	entry	NOUN
arestyrurj-207	9	36	into	into	ADP
arestyrurj-207	9	37	the	the	DET
arestyrurj-207	9	38	nucleus	nucleus	NOUN
arestyrurj-207	9	39	.	.	PUNCT
arestyrurj-207	10	1	in	in	ADP
arestyrurj-207	10	2	the	the	DET
arestyrurj-207	10	3	nucleus	nucleus	NOUN
arestyrurj-207	10	4	,	,	PUNCT
arestyrurj-207	10	5	beta	beta	NOUN
arestyrurj-207	10	6	-	-	PUNCT
arestyrurj-207	10	7	catenin	catenin	NOUN
arestyrurj-207	10	8	promotes	promote	VERB
arestyrurj-207	10	9	the	the	DET
arestyrurj-207	10	10	transcription	transcription	NOUN
arestyrurj-207	10	11	of	of	ADP
arestyrurj-207	10	12	wnt	wnt	PROPN
arestyrurj-207	10	13	target	target	NOUN
arestyrurj-207	10	14	genes	gene	NOUN
arestyrurj-207	10	15	,	,	PUNCT
arestyrurj-207	10	16	causing	cause	VERB
arestyrurj-207	10	17	rapid	rapid	ADJ
arestyrurj-207	10	18	cell	cell	NOUN
arestyrurj-207	10	19	proliferation	proliferation	NOUN
arestyrurj-207	10	20	(	(	PUNCT
arestyrurj-207	10	21	cleavers	cleaver	NOUN
arestyrurj-207	10	22	and	and	CCONJ
arestyrurj-207	10	23	nusse	nusse	NOUN
arestyrurj-207	10	24	,	,	PUNCT
arestyrurj-207	10	25	2012	2012	NUM
arestyrurj-207	10	26	)	)	PUNCT
arestyrurj-207	10	27	.	.	PUNCT
arestyrurj-207	11	1	cells	cell	NOUN
arestyrurj-207	11	2	dividing	divide	VERB
arestyrurj-207	11	3	at	at	ADP
arestyrurj-207	11	4	an	an	DET
arestyrurj-207	11	5	accelerated	accelerated	ADJ
arestyrurj-207	11	6	rate	rate	NOUN
arestyrurj-207	11	7	can	can	AUX
arestyrurj-207	11	8	become	become	VERB
arestyrurj-207	11	9	cancerous	cancerous	ADJ
arestyrurj-207	11	10	and	and	CCONJ
arestyrurj-207	11	11	eventually	eventually	ADV
arestyrurj-207	11	12	lead	lead	VERB
arestyrurj-207	11	13	to	to	ADP
arestyrurj-207	11	14	the	the	DET
arestyrurj-207	11	15	formation	formation	NOUN
arestyrurj-207	11	16	of	of	ADP
arestyrurj-207	11	17	a	a	DET
arestyrurj-207	11	18	tumor	tumor	NOUN
arestyrurj-207	11	19	.	.	PUNCT
arestyrurj-207	12	1	the	the	DET
arestyrurj-207	12	2	intestinal	intestinal	ADJ
arestyrurj-207	12	3	stem	stem	NOUN
arestyrurj-207	12	4	cell	cell	NOUN
arestyrurj-207	12	5	niche	niche	NOUN
arestyrurj-207	12	6	is	be	AUX
arestyrurj-207	12	7	primarily	primarily	ADV
arestyrurj-207	12	8	made	make	VERB
arestyrurj-207	12	9	up	up	ADP
arestyrurj-207	12	10	of	of	ADP
arestyrurj-207	12	11	several	several	ADJ
arestyrurj-207	12	12	cell	cell	NOUN
arestyrurj-207	12	13	types	type	NOUN
arestyrurj-207	12	14	,	,	PUNCT
arestyrurj-207	12	15	including	include	VERB
arestyrurj-207	12	16	:	:	PUNCT
arestyrurj-207	12	17	(	(	PUNCT
arestyrurj-207	12	18	1	1	X
arestyrurj-207	12	19	)	)	PUNCT
arestyrurj-207	12	20	differentiated	differentiated	ADJ
arestyrurj-207	12	21	cells	cell	NOUN
arestyrurj-207	12	22	responsible	responsible	ADJ
arestyrurj-207	12	23	for	for	ADP
arestyrurj-207	12	24	the	the	DET
arestyrurj-207	12	25	transport	transport	NOUN
arestyrurj-207	12	26	and	and	CCONJ
arestyrurj-207	12	27	absorption	absorption	NOUN
arestyrurj-207	12	28	of	of	ADP
arestyrurj-207	12	29	nutrients	nutrient	NOUN
arestyrurj-207	12	30	,	,	PUNCT
arestyrurj-207	12	31	and	and	CCONJ
arestyrurj-207	12	32	(	(	PUNCT
arestyrurj-207	12	33	2	2	X
arestyrurj-207	12	34	)	)	PUNCT
arestyrurj-207	12	35	mesenchymal	mesenchymal	NOUN
arestyrurj-207	12	36	cells	cell	NOUN
arestyrurj-207	12	37	which	which	PRON
arestyrurj-207	12	38	supply	supply	VERB
arestyrurj-207	12	39	signals	signal	NOUN
arestyrurj-207	12	40	to	to	ADP
arestyrurj-207	12	41	the	the	DET
arestyrurj-207	12	42	epithelial	epithelial	ADJ
arestyrurj-207	12	43	cells	cell	NOUN
arestyrurj-207	12	44	to	to	PART
arestyrurj-207	12	45	maintain	maintain	VERB
arestyrurj-207	12	46	homeostasis	homeostasis	NOUN
arestyrurj-207	12	47	.	.	PUNCT
arestyrurj-207	13	1	increased	increase	VERB
arestyrurj-207	13	2	wnt	wnt	NOUN
arestyrurj-207	13	3	signaling	signal	VERB
arestyrurj-207	13	4	can	can	AUX
arestyrurj-207	13	5	be	be	AUX
arestyrurj-207	13	6	induced	induce	VERB
arestyrurj-207	13	7	by	by	ADP
arestyrurj-207	13	8	activating	activate	VERB
arestyrurj-207	13	9	the	the	DET
arestyrurj-207	13	10	beta	beta	NOUN
arestyrurj-207	13	11	-	-	PUNCT
arestyrurj-207	13	12	catenin	catenin	NOUN
arestyrurj-207	13	13	gene	gene	NOUN
arestyrurj-207	13	14	,	,	PUNCT
arestyrurj-207	13	15	which	which	PRON
arestyrurj-207	13	16	allows	allow	VERB
arestyrurj-207	13	17	for	for	ADP
arestyrurj-207	13	18	abnormal	abnormal	ADJ
arestyrurj-207	13	19	epithelial	epithelial	ADJ
arestyrurj-207	13	20	growth	growth	NOUN
arestyrurj-207	13	21	.	.	PUNCT
arestyrurj-207	14	1	due	due	ADP
arestyrurj-207	14	2	to	to	ADP
arestyrurj-207	14	3	the	the	DET
arestyrurj-207	14	4	expression	expression	NOUN
arestyrurj-207	14	5	of	of	ADP
arestyrurj-207	14	6	tamoxifen	tamoxifen	PROPN
arestyrurj-207	14	7	inducible	inducible	PROPN
arestyrurj-207	14	8	cre	cre	PROPN
arestyrurj-207	14	9	recombinase	recombinase	NOUN
arestyrurj-207	14	10	,	,	PUNCT
arestyrurj-207	14	11	villin	villin	PROPN
arestyrurj-207	14	12	-	-	PUNCT
arestyrurj-207	14	13	creert2	creert2	NOUN
arestyrurj-207	14	14	transgenic	transgenic	NOUN
arestyrurj-207	14	15	mice	mouse	NOUN
arestyrurj-207	14	16	have	have	VERB
arestyrurj-207	14	17	the	the	DET
arestyrurj-207	14	18	ability	ability	NOUN
arestyrurj-207	14	19	to	to	PART
arestyrurj-207	14	20	delete	delete	VERB
arestyrurj-207	14	21	exon	exon	NOUN
arestyrurj-207	14	22	3	3	NUM
arestyrurj-207	14	23	of	of	ADP
arestyrurj-207	14	24	the	the	DET
arestyrurj-207	14	25	beta	beta	NOUN
arestyrurj-207	14	26	-	-	PUNCT
arestyrurj-207	14	27	catenin	catenin	NOUN
arestyrurj-207	14	28	allele	allele	NOUN
arestyrurj-207	14	29	in	in	ADP
arestyrurj-207	14	30	the	the	DET
arestyrurj-207	14	31	intestinal	intestinal	ADJ
arestyrurj-207	14	32	epithelium	epithelium	NOUN
arestyrurj-207	14	33	(	(	PUNCT
arestyrurj-207	14	34	marjou	marjou	NOUN
arestyrurj-207	14	35	et	et	PROPN
arestyrurj-207	14	36	al	al	PROPN
arestyrurj-207	14	37	.	.	PROPN
arestyrurj-207	14	38	,	,	PUNCT
arestyrurj-207	14	39	2004	2004	NUM
arestyrurj-207	14	40	)	)	PUNCT
arestyrurj-207	14	41	.	.	PUNCT
arestyrurj-207	15	1	mice	mouse	NOUN
arestyrurj-207	15	2	expressing	express	VERB
arestyrurj-207	15	3	villin	villin	PROPN
arestyrurj-207	15	4	-	-	PUNCT
arestyrurj-207	15	5	creert2	creert2	PROPN
arestyrurj-207	15	6	can	can	AUX
arestyrurj-207	15	7	delete	delete	VERB
arestyrurj-207	15	8	a	a	DET
arestyrurj-207	15	9	portion	portion	NOUN
arestyrurj-207	15	10	of	of	ADP
arestyrurj-207	15	11	the	the	DET
arestyrurj-207	15	12	beta	beta	NOUN
arestyrurj-207	15	13	-	-	PUNCT
arestyrurj-207	15	14	catenin	catenin	NOUN
arestyrurj-207	15	15	gene	gene	NOUN
arestyrurj-207	15	16	in	in	ADP
arestyrurj-207	15	17	the	the	DET
arestyrurj-207	15	18	presence	presence	NOUN
arestyrurj-207	15	19	of	of	ADP
arestyrurj-207	15	20	tamoxifen	tamoxifen	NOUN
arestyrurj-207	15	21	,	,	PUNCT
arestyrurj-207	15	22	resulting	result	VERB
arestyrurj-207	15	23	in	in	ADP
arestyrurj-207	15	24	a	a	DET
arestyrurj-207	15	25	more	more	ADV
arestyrurj-207	15	26	transcriptionally	transcriptionally	ADV
arestyrurj-207	15	27	active	active	ADJ
arestyrurj-207	15	28	form	form	NOUN
arestyrurj-207	15	29	of	of	ADP
arestyrurj-207	15	30	the	the	DET
arestyrurj-207	15	31	gene	gene	NOUN
arestyrurj-207	15	32	.	.	PUNCT
arestyrurj-207	16	1	mouse	mouse	NOUN
arestyrurj-207	16	2	models	model	NOUN
arestyrurj-207	16	3	have	have	AUX
arestyrurj-207	16	4	shown	show	VERB
arestyrurj-207	16	5	that	that	SCONJ
arestyrurj-207	16	6	mice	mouse	NOUN
arestyrurj-207	16	7	with	with	ADP
arestyrurj-207	16	8	villin	villin	PROPN
arestyrurj-207	16	9	-	-	PUNCT
arestyrurj-207	16	10	creert2	creert2	PROPN
arestyrurj-207	16	11	and	and	CCONJ
arestyrurj-207	16	12	injected	inject	VERB
arestyrurj-207	16	13	with	with	ADP
arestyrurj-207	16	14	tamoxifen	tamoxifen	NOUN
arestyrurj-207	16	15	show	show	VERB
arestyrurj-207	16	16	visible	visible	ADJ
arestyrurj-207	16	17	malignant	malignant	ADJ
arestyrurj-207	16	18	tissue	tissue	NOUN
arestyrurj-207	16	19	transformation	transformation	NOUN
arestyrurj-207	16	20	in	in	ADP
arestyrurj-207	16	21	the	the	DET
arestyrurj-207	16	22	duodenum	duodenum	NOUN
arestyrurj-207	16	23	.	.	PUNCT
arestyrurj-207	17	1	but	but	CCONJ
arestyrurj-207	17	2	in	in	ADP
arestyrurj-207	17	3	organoid	organoid	PROPN
arestyrurj-207	17	4	models	model	NOUN
arestyrurj-207	17	5	,	,	PUNCT
arestyrurj-207	17	6	exposed	expose	VERB
arestyrurj-207	17	7	to	to	ADP
arestyrurj-207	17	8	tamoxifen	tamoxifen	NOUN
arestyrurj-207	17	9	,	,	PUNCT
arestyrurj-207	17	10	aresty	aresty	PROPN
arestyrurj-207	17	11	rutgers	rutgers	PROPN
arestyrurj-207	17	12	undergraduate	undergraduate	PROPN
arestyrurj-207	17	13	research	research	PROPN
arestyrurj-207	17	14	journal	journal	PROPN
arestyrurj-207	17	15	,	,	PUNCT
arestyrurj-207	17	16	volume	volume	NOUN
arestyrurj-207	17	17	i	i	PRON
arestyrurj-207	17	18	,	,	PUNCT
arestyrurj-207	17	19	issue	issue	NOUN
arestyrurj-207	17	20	iv	iv	NUM
arestyrurj-207	17	21	rapid	rapid	ADJ
arestyrurj-207	17	22	cell	cell	NOUN
arestyrurj-207	17	23	proliferation	proliferation	NOUN
arestyrurj-207	17	24	can	can	AUX
arestyrurj-207	17	25	be	be	AUX
arestyrurj-207	17	26	seen	see	VERB
arestyrurj-207	17	27	almost	almost	ADV
arestyrurj-207	17	28	immediately	immediately	ADV
arestyrurj-207	17	29	.	.	PUNCT
arestyrurj-207	18	1	however	however	ADV
arestyrurj-207	18	2	,	,	PUNCT
arestyrurj-207	18	3	epithelial	epithelial	ADJ
arestyrurj-207	18	4	transformation	transformation	NOUN
arestyrurj-207	18	5	only	only	ADV
arestyrurj-207	18	6	becomes	become	VERB
arestyrurj-207	18	7	visible	visible	ADJ
arestyrurj-207	18	8	around	around	ADP
arestyrurj-207	18	9	day	day	NOUN
arestyrurj-207	18	10	13	13	NUM
arestyrurj-207	18	11	in	in	ADP
arestyrurj-207	18	12	mouse	mouse	NOUN
arestyrurj-207	18	13	models	model	NOUN
arestyrurj-207	18	14	.	.	PUNCT
arestyrurj-207	19	1	although	although	SCONJ
arestyrurj-207	19	2	organoids	organoid	NOUN
arestyrurj-207	19	3	mimic	mimic	VERB
arestyrurj-207	19	4	intestinal	intestinal	ADJ
arestyrurj-207	19	5	stem	stem	NOUN
arestyrurj-207	19	6	cells	cell	NOUN
arestyrurj-207	19	7	(	(	PUNCT
arestyrurj-207	19	8	crypts	crypt	NOUN
arestyrurj-207	19	9	)	)	PUNCT
arestyrurj-207	19	10	in	in	ADP
arestyrurj-207	19	11	vitro	vitro	X
arestyrurj-207	19	12	,	,	PUNCT
arestyrurj-207	19	13	they	they	PRON
arestyrurj-207	19	14	do	do	AUX
arestyrurj-207	19	15	not	not	PART
arestyrurj-207	19	16	provide	provide	VERB
arestyrurj-207	19	17	a	a	DET
arestyrurj-207	19	18	holistic	holistic	ADJ
arestyrurj-207	19	19	view	view	NOUN
arestyrurj-207	19	20	of	of	ADP
arestyrurj-207	19	21	a	a	DET
arestyrurj-207	19	22	biological	biological	ADJ
arestyrurj-207	19	23	system	system	NOUN
arestyrurj-207	19	24	.	.	PUNCT
arestyrurj-207	20	1	for	for	ADP
arestyrurj-207	20	2	example	example	NOUN
arestyrurj-207	20	3	,	,	PUNCT
arestyrurj-207	20	4	they	they	PRON
arestyrurj-207	20	5	lack	lack	VERB
arestyrurj-207	20	6	the	the	DET
arestyrurj-207	20	7	presence	presence	NOUN
arestyrurj-207	20	8	of	of	ADP
arestyrurj-207	20	9	the	the	DET
arestyrurj-207	20	10	mesenchyme	mesenchyme	NOUN
arestyrurj-207	20	11	.	.	PUNCT
arestyrurj-207	21	1	this	this	PRON
arestyrurj-207	21	2	suggests	suggest	VERB
arestyrurj-207	21	3	that	that	SCONJ
arestyrurj-207	21	4	the	the	DET
arestyrurj-207	21	5	mesenchyme	mesenchyme	NOUN
arestyrurj-207	21	6	must	must	AUX
arestyrurj-207	21	7	play	play	VERB
arestyrurj-207	21	8	some	some	DET
arestyrurj-207	21	9	role	role	NOUN
arestyrurj-207	21	10	in	in	ADP
arestyrurj-207	21	11	the	the	DET
arestyrurj-207	21	12	suppression	suppression	NOUN
arestyrurj-207	21	13	of	of	ADP
arestyrurj-207	21	14	mutant	mutant	ADJ
arestyrurj-207	21	15	growth	growth	NOUN
arestyrurj-207	21	16	.	.	PUNCT
arestyrurj-207	22	1	however	however	ADV
arestyrurj-207	22	2	,	,	PUNCT
arestyrurj-207	22	3	the	the	DET
arestyrurj-207	22	4	way	way	NOUN
arestyrurj-207	22	5	mesenchyme	mesenchyme	NOUN
arestyrurj-207	22	6	and	and	CCONJ
arestyrurj-207	22	7	epithelial	epithelial	ADJ
arestyrurj-207	22	8	cells	cell	NOUN
arestyrurj-207	22	9	influence	influence	VERB
arestyrurj-207	22	10	one	one	NOUN
arestyrurj-207	22	11	another	another	PRON
arestyrurj-207	22	12	is	be	AUX
arestyrurj-207	22	13	unknown	unknown	ADJ
arestyrurj-207	22	14	.	.	PUNCT
arestyrurj-207	23	1	yet	yet	ADV
arestyrurj-207	23	2	,	,	PUNCT
arestyrurj-207	23	3	it	it	PRON
arestyrurj-207	23	4	is	be	AUX
arestyrurj-207	23	5	known	know	VERB
arestyrurj-207	23	6	that	that	SCONJ
arestyrurj-207	23	7	mesenchymal	mesenchymal	NOUN
arestyrurj-207	23	8	-	-	PUNCT
arestyrurj-207	23	9	derived	derive	VERB
arestyrurj-207	23	10	factors	factor	NOUN
arestyrurj-207	23	11	are	be	AUX
arestyrurj-207	23	12	essential	essential	ADJ
arestyrurj-207	23	13	to	to	PART
arestyrurj-207	23	14	maintain	maintain	VERB
arestyrurj-207	23	15	intestinal	intestinal	ADJ
arestyrurj-207	23	16	epithelial	epithelial	ADJ
arestyrurj-207	23	17	stem	stem	NOUN
arestyrurj-207	23	18	cells	cell	NOUN
arestyrurj-207	23	19	,	,	PUNCT
arestyrurj-207	23	20	so	so	SCONJ
arestyrurj-207	23	21	the	the	DET
arestyrurj-207	23	22	reduction	reduction	NOUN
arestyrurj-207	23	23	of	of	ADP
arestyrurj-207	23	24	these	these	DET
arestyrurj-207	23	25	factors	factor	NOUN
arestyrurj-207	23	26	may	may	AUX
arestyrurj-207	23	27	be	be	AUX
arestyrurj-207	23	28	contributing	contribute	VERB
arestyrurj-207	23	29	to	to	ADP
arestyrurj-207	23	30	the	the	DET
arestyrurj-207	23	31	suppression	suppression	NOUN
arestyrurj-207	23	32	of	of	ADP
arestyrurj-207	23	33	intestinal	intestinal	ADJ
arestyrurj-207	23	34	transformation	transformation	NOUN
arestyrurj-207	23	35	in	in	ADP
arestyrurj-207	23	36	the	the	DET
arestyrurj-207	23	37	transgenic	transgenic	NOUN
arestyrurj-207	23	38	mouse	mouse	NOUN
arestyrurj-207	23	39	(	(	PUNCT
arestyrurj-207	23	40	stzepourginski	stzepourginski	NOUN
arestyrurj-207	23	41	et	et	PROPN
arestyrurj-207	23	42	al	al	PROPN
arestyrurj-207	23	43	.	.	PROPN
arestyrurj-207	23	44	,	,	PUNCT
arestyrurj-207	23	45	2017	2017	NUM
arestyrurj-207	23	46	)	)	PUNCT
arestyrurj-207	23	47	.	.	PUNCT
arestyrurj-207	24	1	areg	areg	NOUN
arestyrurj-207	24	2	,	,	PUNCT
arestyrurj-207	24	3	a	a	DET
arestyrurj-207	24	4	ligand	ligand	NOUN
arestyrurj-207	24	5	of	of	ADP
arestyrurj-207	24	6	egfr	egfr	NOUN
arestyrurj-207	24	7	(	(	PUNCT
arestyrurj-207	24	8	epidermal	epidermal	ADJ
arestyrurj-207	24	9	growth	growth	NOUN
arestyrurj-207	24	10	factor	factor	NOUN
arestyrurj-207	24	11	receptor	receptor	NOUN
arestyrurj-207	24	12	)	)	PUNCT
arestyrurj-207	24	13	,	,	PUNCT
arestyrurj-207	24	14	can	can	AUX
arestyrurj-207	24	15	trigger	trigger	VERB
arestyrurj-207	24	16	signaling	signal	VERB
arestyrurj-207	24	17	cascades	cascade	NOUN
arestyrurj-207	24	18	that	that	PRON
arestyrurj-207	24	19	mediate	mediate	VERB
arestyrurj-207	24	20	cell	cell	NOUN
arestyrurj-207	24	21	survival	survival	NOUN
arestyrurj-207	24	22	,	,	PUNCT
arestyrurj-207	24	23	proliferation	proliferation	NOUN
arestyrurj-207	24	24	,	,	PUNCT
arestyrurj-207	24	25	and	and	CCONJ
arestyrurj-207	24	26	motility	motility	NOUN
arestyrurj-207	24	27	.	.	PUNCT
arestyrurj-207	25	1	thus	thus	ADV
arestyrurj-207	25	2	,	,	PUNCT
arestyrurj-207	25	3	areg	areg	NOUN
arestyrurj-207	25	4	may	may	AUX
arestyrurj-207	25	5	be	be	AUX
arestyrurj-207	25	6	a	a	DET
arestyrurj-207	25	7	candidate	candidate	NOUN
arestyrurj-207	25	8	ligand	ligand	NOUN
arestyrurj-207	25	9	that	that	PRON
arestyrurj-207	25	10	allows	allow	VERB
arestyrurj-207	25	11	the	the	DET
arestyrurj-207	25	12	epithelium	epithelium	NOUN
arestyrurj-207	25	13	to	to	PART
arestyrurj-207	25	14	communicate	communicate	VERB
arestyrurj-207	25	15	with	with	ADP
arestyrurj-207	25	16	the	the	DET
arestyrurj-207	25	17	mesenchyme	mesenchyme	NOUN
arestyrurj-207	25	18	(	(	PUNCT
arestyrurj-207	25	19	wang	wang	PROPN
arestyrurj-207	25	20	et	et	PROPN
arestyrurj-207	25	21	al	al	PROPN
arestyrurj-207	25	22	.	.	PROPN
arestyrurj-207	25	23	,	,	PUNCT
arestyrurj-207	25	24	2020	2020	NUM
arestyrurj-207	25	25	)	)	PUNCT
arestyrurj-207	25	26	.	.	PUNCT
arestyrurj-207	26	1	transformed	transform	VERB
arestyrurj-207	26	2	epithelium	epithelium	NOUN
arestyrurj-207	26	3	expresses	express	VERB
arestyrurj-207	26	4	high	high	ADJ
arestyrurj-207	26	5	levels	level	NOUN
arestyrurj-207	26	6	of	of	ADP
arestyrurj-207	26	7	areg	areg	NOUN
arestyrurj-207	26	8	,	,	PUNCT
arestyrurj-207	26	9	which	which	PRON
arestyrurj-207	26	10	may	may	AUX
arestyrurj-207	26	11	be	be	AUX
arestyrurj-207	26	12	sensed	sense	VERB
arestyrurj-207	26	13	by	by	ADP
arestyrurj-207	26	14	mesenchyme	mesenchyme	NOUN
arestyrurj-207	26	15	cells	cell	NOUN
arestyrurj-207	26	16	.	.	PUNCT
arestyrurj-207	27	1	mesenchyme	mesenchyme	NOUN
arestyrurj-207	27	2	cells	cell	NOUN
arestyrurj-207	27	3	like	like	ADP
arestyrurj-207	27	4	pdgfrahi	pdgfrahi	PROPN
arestyrurj-207	27	5	are	be	AUX
arestyrurj-207	27	6	enriched	enrich	VERB
arestyrurj-207	27	7	near	near	ADP
arestyrurj-207	27	8	the	the	DET
arestyrurj-207	27	9	crypt	crypt	NOUN
arestyrurj-207	27	10	-	-	PUNCT
arestyrurj-207	27	11	villus	villus	NOUN
arestyrurj-207	27	12	junction	junction	NOUN
arestyrurj-207	27	13	where	where	SCONJ
arestyrurj-207	27	14	stem	stem	NOUN
arestyrurj-207	27	15	cells	cell	NOUN
arestyrurj-207	27	16	reside	reside	VERB
arestyrurj-207	27	17	and	and	CCONJ
arestyrurj-207	27	18	promote	promote	VERB
arestyrurj-207	27	19	bmp	bmp	NOUN
arestyrurj-207	27	20	ligands	ligand	NOUN
arestyrurj-207	27	21	(	(	PUNCT
arestyrurj-207	27	22	promotes	promote	VERB
arestyrurj-207	27	23	differentiation	differentiation	NOUN
arestyrurj-207	27	24	/	/	SYM
arestyrurj-207	27	25	blocks	block	NOUN
arestyrurj-207	27	26	proliferation	proliferation	NOUN
arestyrurj-207	27	27	)	)	PUNCT
arestyrurj-207	27	28	.	.	PUNCT
arestyrurj-207	28	1	a	a	DET
arestyrurj-207	28	2	subset	subset	NOUN
arestyrurj-207	28	3	of	of	ADP
arestyrurj-207	28	4	pdgfralo	pdgfralo	NOUN
arestyrurj-207	28	5	cells	cell	NOUN
arestyrurj-207	28	6	can	can	AUX
arestyrurj-207	28	7	be	be	AUX
arestyrurj-207	28	8	found	find	VERB
arestyrurj-207	28	9	at	at	ADP
arestyrurj-207	28	10	the	the	DET
arestyrurj-207	28	11	bottom	bottom	NOUN
arestyrurj-207	28	12	of	of	ADP
arestyrurj-207	28	13	crypts	crypt	NOUN
arestyrurj-207	28	14	and	and	CCONJ
arestyrurj-207	28	15	provide	provide	VERB
arestyrurj-207	28	16	growth	growth	NOUN
arestyrurj-207	28	17	factors	factor	NOUN
arestyrurj-207	28	18	for	for	ADP
arestyrurj-207	28	19	stem	stem	NOUN
arestyrurj-207	28	20	cells	cell	NOUN
arestyrurj-207	28	21	(	(	PUNCT
arestyrurj-207	28	22	mccarthy	mccarthy	PROPN
arestyrurj-207	28	23	et	et	PROPN
arestyrurj-207	28	24	al	al	PROPN
arestyrurj-207	28	25	.	.	PROPN
arestyrurj-207	28	26	,	,	PUNCT
arestyrurj-207	28	27	2020	2020	NUM
arestyrurj-207	28	28	)	)	PUNCT
arestyrurj-207	28	29	.	.	PUNCT
arestyrurj-207	29	1	if	if	SCONJ
arestyrurj-207	29	2	areg	areg	NOUN
arestyrurj-207	29	3	is	be	AUX
arestyrurj-207	29	4	communicating	communicate	VERB
arestyrurj-207	29	5	with	with	ADP
arestyrurj-207	29	6	pdgfralo	pdgfralo	NOUN
arestyrurj-207	29	7	cells	cell	NOUN
arestyrurj-207	29	8	in	in	ADP
arestyrurj-207	29	9	the	the	DET
arestyrurj-207	29	10	mesenchyme	mesenchyme	NOUN
arestyrurj-207	29	11	,	,	PUNCT
arestyrurj-207	29	12	the	the	DET
arestyrurj-207	29	13	pdgfralo	pdgfralo	NOUN
arestyrurj-207	29	14	cells	cell	NOUN
arestyrurj-207	29	15	would	would	AUX
arestyrurj-207	29	16	express	express	VERB
arestyrurj-207	29	17	decreased	decreased	ADJ
arestyrurj-207	29	18	levels	level	NOUN
arestyrurj-207	29	19	of	of	ADP
arestyrurj-207	29	20	grem1	grem1	PROPN
arestyrurj-207	29	21	,	,	PUNCT
arestyrurj-207	29	22	a	a	DET
arestyrurj-207	29	23	protein	protein	NOUN
arestyrurj-207	29	24	that	that	PRON
arestyrurj-207	29	25	functions	function	VERB
arestyrurj-207	29	26	to	to	PART
arestyrurj-207	29	27	suppress	suppress	VERB
arestyrurj-207	29	28	bmp	bmp	NOUN
arestyrurj-207	29	29	and	and	CCONJ
arestyrurj-207	29	30	permits	permit	VERB
arestyrurj-207	29	31	proliferation	proliferation	NOUN
arestyrurj-207	29	32	.	.	PUNCT
arestyrurj-207	30	1	subsequently	subsequently	ADV
arestyrurj-207	30	2	,	,	PUNCT
arestyrurj-207	30	3	this	this	PRON
arestyrurj-207	30	4	may	may	AUX
arestyrurj-207	30	5	lead	lead	VERB
arestyrurj-207	30	6	to	to	ADP
arestyrurj-207	30	7	an	an	DET
arestyrurj-207	30	8	upregulation	upregulation	NOUN
arestyrurj-207	30	9	in	in	ADP
arestyrurj-207	30	10	expression	expression	NOUN
arestyrurj-207	30	11	levels	level	NOUN
arestyrurj-207	30	12	of	of	ADP
arestyrurj-207	30	13	bmp	bmp	PROPN
arestyrurj-207	30	14	.	.	PROPN
arestyrurj-207	31	1	early	early	ADJ
arestyrurj-207	31	2	intestinal	intestinal	ADJ
arestyrurj-207	31	3	tumorigenesis	tumorigenesis	NOUN
arestyrurj-207	31	4	reflects	reflect	VERB
arestyrurj-207	31	5	the	the	DET
arestyrurj-207	31	6	deregulation	deregulation	NOUN
arestyrurj-207	31	7	of	of	ADP
arestyrurj-207	31	8	wnt	wnt	NOUN
arestyrurj-207	31	9	and	and	CCONJ
arestyrurj-207	31	10	bmp	bmp	PROPN
arestyrurj-207	31	11	signals	signal	NOUN
arestyrurj-207	31	12	(	(	PUNCT
arestyrurj-207	31	13	davis	davis	PROPN
arestyrurj-207	31	14	et	et	PROPN
arestyrurj-207	31	15	al	al	PROPN
arestyrurj-207	31	16	;	;	PUNCT
arestyrurj-207	31	17	2015	2015	NUM
arestyrurj-207	31	18	)	)	PUNCT
arestyrurj-207	31	19	.	.	PUNCT
arestyrurj-207	32	1	it	it	PRON
arestyrurj-207	32	2	has	have	AUX
arestyrurj-207	32	3	also	also	ADV
arestyrurj-207	32	4	been	be	AUX
arestyrurj-207	32	5	recognized	recognize	VERB
arestyrurj-207	32	6	that	that	SCONJ
arestyrurj-207	32	7	bmp	bmp	NOUN
arestyrurj-207	32	8	signaling	signaling	NOUN
arestyrurj-207	32	9	restricts	restrict	VERB
arestyrurj-207	32	10	intestinal	intestinal	ADJ
arestyrurj-207	32	11	epithelium	epithelium	NOUN
arestyrurj-207	32	12	hyperproliferation	hyperproliferation	NOUN
arestyrurj-207	32	13	(	(	PUNCT
arestyrurj-207	32	14	qi	qi	X
arestyrurj-207	32	15	et	et	NOUN
arestyrurj-207	32	16	al	al	PROPN
arestyrurj-207	32	17	.	.	PROPN
arestyrurj-207	32	18	,	,	PUNCT
arestyrurj-207	32	19	2017	2017	NUM
arestyrurj-207	32	20	)	)	PUNCT
arestyrurj-207	32	21	.	.	PUNCT
arestyrurj-207	33	1	if	if	SCONJ
arestyrurj-207	33	2	we	we	PRON
arestyrurj-207	33	3	could	could	AUX
arestyrurj-207	33	4	understand	understand	VERB
arestyrurj-207	33	5	how	how	SCONJ
arestyrurj-207	33	6	the	the	DET
arestyrurj-207	33	7	mesenchyme	mesenchyme	NOUN
arestyrurj-207	33	8	is	be	AUX
arestyrurj-207	33	9	communicating	communicate	VERB
arestyrurj-207	33	10	with	with	ADP
arestyrurj-207	33	11	the	the	DET
arestyrurj-207	33	12	epithelium	epithelium	NOUN
arestyrurj-207	33	13	,	,	PUNCT
arestyrurj-207	33	14	it	it	PRON
arestyrurj-207	33	15	would	would	AUX
arestyrurj-207	33	16	give	give	VERB
arestyrurj-207	33	17	insight	insight	NOUN
arestyrurj-207	33	18	to	to	ADP
arestyrurj-207	33	19	how	how	SCONJ
arestyrurj-207	33	20	it	it	PRON
arestyrurj-207	33	21	is	be	AUX
arestyrurj-207	33	22	able	able	ADJ
arestyrurj-207	33	23	to	to	PART
arestyrurj-207	33	24	suppress	suppress	VERB
arestyrurj-207	33	25	the	the	DET
arestyrurj-207	33	26	abnormal	abnormal	ADJ
arestyrurj-207	33	27	growth	growth	NOUN
arestyrurj-207	33	28	,	,	PUNCT
arestyrurj-207	33	29	allowing	allow	VERB
arestyrurj-207	33	30	for	for	ADP
arestyrurj-207	33	31	novel	novel	ADJ
arestyrurj-207	33	32	therapeutic	therapeutic	ADJ
arestyrurj-207	33	33	interventions	intervention	NOUN
arestyrurj-207	33	34	during	during	ADP
arestyrurj-207	33	35	initial	initial	ADJ
arestyrurj-207	33	36	tumor	tumor	NOUN
arestyrurj-207	33	37	development	development	NOUN
arestyrurj-207	33	38	.	.	PUNCT
arestyrurj-207	34	1	the	the	DET
arestyrurj-207	34	2	goal	goal	NOUN
arestyrurj-207	34	3	of	of	ADP
arestyrurj-207	34	4	this	this	DET
arestyrurj-207	34	5	project	project	NOUN
arestyrurj-207	34	6	is	be	AUX
arestyrurj-207	34	7	to	to	PART
arestyrurj-207	34	8	learn	learn	VERB
arestyrurj-207	34	9	how	how	SCONJ
arestyrurj-207	34	10	epithelial	epithelial	ADJ
arestyrurj-207	34	11	cells	cell	NOUN
arestyrurj-207	34	12	are	be	AUX
arestyrurj-207	34	13	communicating	communicate	VERB
arestyrurj-207	34	14	with	with	ADP
arestyrurj-207	34	15	mesenchyme	mesenchyme	NOUN
arestyrurj-207	34	16	cells	cell	NOUN
arestyrurj-207	34	17	in	in	ADP
arestyrurj-207	34	18	an	an	DET
arestyrurj-207	34	19	elevated	elevated	ADJ
arestyrurj-207	34	20	wnt	wnt	NOUN
arestyrurj-207	34	21	activity	activity	NOUN
arestyrurj-207	34	22	background	background	NOUN
arestyrurj-207	34	23	.	.	PUNCT
arestyrurj-207	35	1	elevated	elevated	ADJ
arestyrurj-207	35	2	levels	level	NOUN
arestyrurj-207	35	3	of	of	ADP
arestyrurj-207	35	4	wnt	wnt	PROPN
arestyrurj-207	35	5	prevents	prevent	VERB
arestyrurj-207	35	6	beta	beta	NOUN
arestyrurj-207	35	7	-	-	PUNCT
arestyrurj-207	35	8	catenin	catenin	NOUN
arestyrurj-207	35	9	from	from	ADP
arestyrurj-207	35	10	being	be	AUX
arestyrurj-207	35	11	degraded	degrade	VERB
arestyrurj-207	35	12	,	,	PUNCT
arestyrurj-207	35	13	which	which	PRON
arestyrurj-207	35	14	promotes	promote	VERB
arestyrurj-207	35	15	expression	expression	NOUN
arestyrurj-207	35	16	of	of	ADP
arestyrurj-207	35	17	wnt	wnt	PROPN
arestyrurj-207	35	18	target	target	NOUN
arestyrurj-207	35	19	genes	gene	NOUN
arestyrurj-207	35	20	,	,	PUNCT
arestyrurj-207	35	21	resulting	result	VERB
arestyrurj-207	35	22	in	in	ADP
arestyrurj-207	35	23	the	the	DET
arestyrurj-207	35	24	mutant	mutant	ADJ
arestyrurj-207	35	25	phenotype	phenotype	NOUN
arestyrurj-207	35	26	.	.	PUNCT
arestyrurj-207	36	1	through	through	ADP
arestyrurj-207	36	2	signals	signal	NOUN
arestyrurj-207	36	3	(	(	PUNCT
arestyrurj-207	36	4	e.g.	e.g.	ADV
arestyrurj-207	36	5	areg	areg	NOUN
arestyrurj-207	36	6	)	)	PUNCT
arestyrurj-207	36	7	sent	send	VERB
arestyrurj-207	36	8	by	by	ADP
arestyrurj-207	36	9	the	the	DET
arestyrurj-207	36	10	epithelium	epithelium	NOUN
arestyrurj-207	36	11	,	,	PUNCT
arestyrurj-207	36	12	the	the	DET
arestyrurj-207	36	13	mesenchyme	mesenchyme	NOUN
arestyrurj-207	36	14	may	may	AUX
arestyrurj-207	36	15	detect	detect	VERB
arestyrurj-207	36	16	the	the	DET
arestyrurj-207	36	17	cellular	cellular	ADJ
arestyrurj-207	36	18	transformation	transformation	NOUN
arestyrurj-207	36	19	and	and	CCONJ
arestyrurj-207	36	20	respond	respond	VERB
arestyrurj-207	36	21	in	in	ADP
arestyrurj-207	36	22	hopes	hope	NOUN
arestyrurj-207	36	23	of	of	ADP
arestyrurj-207	36	24	preventing	prevent	VERB
arestyrurj-207	36	25	the	the	DET
arestyrurj-207	36	26	abnormal	abnormal	ADJ
arestyrurj-207	36	27	growth	growth	NOUN
arestyrurj-207	36	28	.	.	PUNCT
arestyrurj-207	37	1	if	if	SCONJ
arestyrurj-207	37	2	mesenchyme	mesenchyme	NOUN
arestyrurj-207	37	3	cells	cell	NOUN
arestyrurj-207	37	4	are	be	AUX
arestyrurj-207	37	5	treated	treat	VERB
arestyrurj-207	37	6	with	with	ADP
arestyrurj-207	37	7	conditioned	condition	VERB
arestyrurj-207	37	8	media	medium	NOUN
arestyrurj-207	37	9	from	from	ADP
arestyrurj-207	37	10	mutant	mutant	ADJ
arestyrurj-207	37	11	organoids	organoid	NOUN
arestyrurj-207	37	12	(	(	PUNCT
arestyrurj-207	37	13	crypts	crypt	NOUN
arestyrurj-207	37	14	)	)	PUNCT
arestyrurj-207	37	15	,	,	PUNCT
arestyrurj-207	37	16	then	then	ADV
arestyrurj-207	37	17	the	the	DET
arestyrurj-207	37	18	genes	gene	NOUN
arestyrurj-207	37	19	which	which	PRON
arestyrurj-207	37	20	are	be	AUX
arestyrurj-207	37	21	altered	alter	VERB
arestyrurj-207	37	22	are	be	AUX
arestyrurj-207	37	23	communicating	communicate	VERB
arestyrurj-207	37	24	with	with	ADP
arestyrurj-207	37	25	the	the	DET
arestyrurj-207	37	26	mesenchyme	mesenchyme	NOUN
arestyrurj-207	37	27	.	.	PUNCT
arestyrurj-207	38	1	if	if	SCONJ
arestyrurj-207	38	2	epithelial	epithelial	ADJ
arestyrurj-207	38	3	cells	cell	NOUN
arestyrurj-207	38	4	undergo	undergo	VERB
arestyrurj-207	38	5	abnormal	abnormal	ADJ
arestyrurj-207	38	6	growth	growth	NOUN
arestyrurj-207	38	7	,	,	PUNCT
arestyrurj-207	38	8	the	the	DET
arestyrurj-207	38	9	ligands	ligand	NOUN
arestyrurj-207	38	10	produced	produce	VERB
arestyrurj-207	38	11	could	could	AUX
arestyrurj-207	38	12	be	be	AUX
arestyrurj-207	38	13	sensed	sense	VERB
arestyrurj-207	38	14	by	by	ADP
arestyrurj-207	38	15	pdgfralo	pdgfralo	NOUN
arestyrurj-207	38	16	cells	cell	NOUN
arestyrurj-207	38	17	in	in	ADP
arestyrurj-207	38	18	the	the	DET
arestyrurj-207	38	19	mesenchyme	mesenchyme	NOUN
arestyrurj-207	38	20	compartment	compartment	NOUN
arestyrurj-207	38	21	,	,	PUNCT
arestyrurj-207	38	22	which	which	PRON
arestyrurj-207	38	23	may	may	AUX
arestyrurj-207	38	24	respond	respond	VERB
arestyrurj-207	38	25	by	by	ADP
arestyrurj-207	38	26	increasing	increase	VERB
arestyrurj-207	38	27	bmp	bmp	ADJ
arestyrurj-207	38	28	genes	gene	NOUN
arestyrurj-207	38	29	and	and	CCONJ
arestyrurj-207	38	30	decreasing	decrease	VERB
arestyrurj-207	38	31	grem1	grem1	NOUN
arestyrurj-207	38	32	and	and	CCONJ
arestyrurj-207	38	33	wnt2b	wnt2b	PROPN
arestyrurj-207	38	34	production	production	NOUN
arestyrurj-207	38	35	.	.	PUNCT
arestyrurj-207	39	1	2	2	NUM
arestyrurj-207	39	2	materials	material	NOUN
arestyrurj-207	39	3	and	and	CCONJ
arestyrurj-207	39	4	methods	method	NOUN
arestyrurj-207	39	5	animal	animal	NOUN
arestyrurj-207	39	6	and	and	CCONJ
arestyrurj-207	39	7	tissue	tissue	NOUN
arestyrurj-207	39	8	processing	processing	NOUN
arestyrurj-207	39	9	animal	animal	NOUN
arestyrurj-207	39	10	experiments	experiment	NOUN
arestyrurj-207	39	11	are	be	AUX
arestyrurj-207	39	12	conducted	conduct	VERB
arestyrurj-207	39	13	in	in	ADP
arestyrurj-207	39	14	accordance	accordance	NOUN
arestyrurj-207	39	15	with	with	ADP
arestyrurj-207	39	16	rutgers	rutgers	PROPN
arestyrurj-207	39	17	university	university	PROPN
arestyrurj-207	39	18	institutional	institutional	ADJ
arestyrurj-207	39	19	animal	animal	NOUN
arestyrurj-207	39	20	care	care	NOUN
arestyrurj-207	39	21	and	and	CCONJ
arestyrurj-207	39	22	use	use	VERB
arestyrurj-207	39	23	committee	committee	NOUN
arestyrurj-207	39	24	(	(	PUNCT
arestyrurj-207	39	25	iacuc	iacuc	NOUN
arestyrurj-207	39	26	)	)	PUNCT
arestyrurj-207	39	27	..	..	PUNCT
arestyrurj-207	40	1	the	the	DET
arestyrurj-207	40	2	transgenic	transgenic	NOUN
arestyrurj-207	40	3	mice	mouse	NOUN
arestyrurj-207	40	4	in	in	ADP
arestyrurj-207	40	5	this	this	DET
arestyrurj-207	40	6	study	study	NOUN
arestyrurj-207	40	7	are	be	AUX
arestyrurj-207	40	8	engineered	engineer	VERB
arestyrurj-207	40	9	to	to	PART
arestyrurj-207	40	10	conditionally	conditionally	ADV
arestyrurj-207	40	11	express	express	VERB
arestyrurj-207	40	12	the	the	DET
arestyrurj-207	40	13	beta	beta	NOUN
arestyrurj-207	40	14	-	-	PUNCT
arestyrurj-207	40	15	catenin	catenin	NOUN
arestyrurj-207	40	16	exon3	exon3	NOUN
arestyrurj-207	40	17	deletion	deletion	NOUN
arestyrurj-207	40	18	.	.	PUNCT
arestyrurj-207	41	1	to	to	PART
arestyrurj-207	41	2	induce	induce	VERB
arestyrurj-207	41	3	recombination	recombination	NOUN
arestyrurj-207	41	4	,	,	PUNCT
arestyrurj-207	41	5	tamoxifen	tamoxifen	NOUN
arestyrurj-207	41	6	(	(	PUNCT
arestyrurj-207	41	7	1mg/20	1mg/20	NUM
arestyrurj-207	41	8	g	g	NOUN
arestyrurj-207	41	9	)	)	PUNCT
arestyrurj-207	41	10	is	be	AUX
arestyrurj-207	41	11	injected	inject	VERB
arestyrurj-207	41	12	intraperitoneally	intraperitoneally	ADV
arestyrurj-207	41	13	for	for	ADP
arestyrurj-207	41	14	4	4	NUM
arestyrurj-207	41	15	days	day	NOUN
arestyrurj-207	41	16	daily	daily	ADV
arestyrurj-207	41	17	.	.	PUNCT
arestyrurj-207	42	1	day	day	NOUN
arestyrurj-207	42	2	1	1	NUM
arestyrurj-207	42	3	is	be	AUX
arestyrurj-207	42	4	considered	consider	VERB
arestyrurj-207	42	5	the	the	DET
arestyrurj-207	42	6	beginning	beginning	NOUN
arestyrurj-207	42	7	of	of	ADP
arestyrurj-207	42	8	treatment	treatment	NOUN
arestyrurj-207	42	9	,	,	PUNCT
arestyrurj-207	42	10	and	and	CCONJ
arestyrurj-207	42	11	mice	mouse	NOUN
arestyrurj-207	42	12	are	be	AUX
arestyrurj-207	42	13	sacrificed	sacrifice	VERB
arestyrurj-207	42	14	and	and	CCONJ
arestyrurj-207	42	15	investigated	investigate	VERB
arestyrurj-207	42	16	at	at	ADP
arestyrurj-207	42	17	day	day	NOUN
arestyrurj-207	42	18	10	10	NUM
arestyrurj-207	42	19	.	.	PUNCT
arestyrurj-207	43	1	this	this	DET
arestyrurj-207	43	2	model	model	NOUN
arestyrurj-207	43	3	is	be	AUX
arestyrurj-207	43	4	ideal	ideal	ADJ
arestyrurj-207	43	5	for	for	ADP
arestyrurj-207	43	6	studying	study	VERB
arestyrurj-207	43	7	tumorigenesis	tumorigenesis	NOUN
arestyrurj-207	43	8	in	in	ADP
arestyrurj-207	43	9	-	-	PUNCT
arestyrurj-207	43	10	vivo	vivo	NOUN
arestyrurj-207	43	11	because	because	SCONJ
arestyrurj-207	43	12	of	of	ADP
arestyrurj-207	43	13	similarities	similarity	NOUN
arestyrurj-207	43	14	in	in	ADP
arestyrurj-207	43	15	mouse	mouse	NOUN
arestyrurj-207	43	16	and	and	CCONJ
arestyrurj-207	43	17	human	human	ADJ
arestyrurj-207	43	18	gastrointestinal	gastrointestinal	ADJ
arestyrurj-207	43	19	tracts	tract	NOUN
arestyrurj-207	43	20	.	.	PUNCT
arestyrurj-207	44	1	at	at	ADP
arestyrurj-207	44	2	day	day	NOUN
arestyrurj-207	44	3	10	10	NUM
arestyrurj-207	44	4	,	,	PUNCT
arestyrurj-207	44	5	mouse	mouse	NOUN
arestyrurj-207	44	6	intestines	intestine	NOUN
arestyrurj-207	44	7	(	(	PUNCT
arestyrurj-207	44	8	duodenum	duodenum	ADJ
arestyrurj-207	44	9	)	)	PUNCT
arestyrurj-207	44	10	are	be	AUX
arestyrurj-207	44	11	collected	collect	VERB
arestyrurj-207	44	12	and	and	CCONJ
arestyrurj-207	44	13	fixed	fix	VERB
arestyrurj-207	44	14	in	in	ADP
arestyrurj-207	44	15	4	4	NUM
arestyrurj-207	44	16	%	%	NOUN
arestyrurj-207	44	17	paraformaldehyde	paraformaldehyde	NOUN
arestyrurj-207	44	18	solution	solution	NOUN
arestyrurj-207	44	19	overnight	overnight	ADV
arestyrurj-207	44	20	at	at	ADP
arestyrurj-207	44	21	4	4	NUM
arestyrurj-207	44	22	°	°	NOUN
arestyrurj-207	44	23	c	c	NOUN
arestyrurj-207	44	24	.	.	PUNCT
arestyrurj-207	45	1	tissues	tissue	NOUN
arestyrurj-207	45	2	are	be	AUX
arestyrurj-207	45	3	then	then	ADV
arestyrurj-207	45	4	washed	wash	VERB
arestyrurj-207	45	5	with	with	ADP
arestyrurj-207	45	6	phosphate	phosphate	NOUN
arestyrurj-207	45	7	-	-	PUNCT
arestyrurj-207	45	8	buffered	buffer	VERB
arestyrurj-207	45	9	saline	saline	NOUN
arestyrurj-207	45	10	(	(	PUNCT
arestyrurj-207	45	11	pbs	pbs	PROPN
arestyrurj-207	45	12	)	)	PUNCT
arestyrurj-207	45	13	and	and	CCONJ
arestyrurj-207	45	14	dehydrated	dehydrate	VERB
arestyrurj-207	45	15	in	in	ADP
arestyrurj-207	45	16	increasing	increase	VERB
arestyrurj-207	45	17	concentrations	concentration	NOUN
arestyrurj-207	45	18	of	of	ADP
arestyrurj-207	45	19	ethanol	ethanol	NOUN
arestyrurj-207	45	20	.	.	PUNCT
arestyrurj-207	46	1	tissues	tissue	NOUN
arestyrurj-207	46	2	are	be	AUX
arestyrurj-207	46	3	then	then	ADV
arestyrurj-207	46	4	transferred	transfer	VERB
arestyrurj-207	46	5	to	to	ADP
arestyrurj-207	46	6	xylene	xylene	NOUN
arestyrurj-207	46	7	and	and	CCONJ
arestyrurj-207	46	8	paraffin	paraffin	NOUN
arestyrurj-207	46	9	mixture	mixture	NOUN
arestyrurj-207	46	10	for	for	ADP
arestyrurj-207	46	11	one	one	NUM
arestyrurj-207	46	12	hour	hour	NOUN
arestyrurj-207	46	13	,	,	PUNCT
arestyrurj-207	46	14	then	then	ADV
arestyrurj-207	46	15	100	100	NUM
arestyrurj-207	46	16	%	%	NOUN
arestyrurj-207	46	17	paraffin	paraffin	NOUN
arestyrurj-207	46	18	for	for	ADP
arestyrurj-207	46	19	another	another	DET
arestyrurj-207	46	20	hour	hour	NOUN
arestyrurj-207	46	21	.	.	PUNCT
arestyrurj-207	47	1	tissues	tissue	NOUN
arestyrurj-207	47	2	are	be	AUX
arestyrurj-207	47	3	embedded	embed	VERB
arestyrurj-207	47	4	for	for	ADP
arestyrurj-207	47	5	sectioning	section	VERB
arestyrurj-207	47	6	.	.	PUNCT
arestyrurj-207	48	1	organoid	organoid	PROPN
arestyrurj-207	48	2	forming	form	VERB
arestyrurj-207	48	3	assay	assay	ADV
arestyrurj-207	48	4	crypt	crypt	NOUN
arestyrurj-207	48	5	-	-	PUNCT
arestyrurj-207	48	6	derived	derive	VERB
arestyrurj-207	48	7	organoids	organoid	NOUN
arestyrurj-207	48	8	are	be	AUX
arestyrurj-207	48	9	isolated	isolate	VERB
arestyrurj-207	48	10	from	from	ADP
arestyrurj-207	48	11	mouse	mouse	NOUN
arestyrurj-207	48	12	duodenum	duodenum	NOUN
arestyrurj-207	48	13	on	on	ADP
arestyrurj-207	48	14	day	day	NOUN
arestyrurj-207	48	15	10	10	NUM
arestyrurj-207	48	16	after	after	SCONJ
arestyrurj-207	48	17	4	4	NUM
arestyrurj-207	48	18	consecutive	consecutive	ADJ
arestyrurj-207	48	19	treatment	treatment	NOUN
arestyrurj-207	48	20	days	day	NOUN
arestyrurj-207	48	21	of	of	ADP
arestyrurj-207	48	22	tamoxifen	tamoxifen	PROPN
arestyrurj-207	48	23	administered	administer	VERB
arestyrurj-207	48	24	at	at	ADP
arestyrurj-207	48	25	1mg/20	1mg/20	NUM
arestyrurj-207	48	26	g	g	NOUN
arestyrurj-207	48	27	mice	mouse	NOUN
arestyrurj-207	48	28	.	.	PUNCT
arestyrurj-207	49	1	collected	collect	VERB
arestyrurj-207	49	2	duodenum	duodenum	ADJ
arestyrurj-207	49	3	samples	sample	NOUN
arestyrurj-207	49	4	are	be	AUX
arestyrurj-207	49	5	washed	wash	VERB
arestyrurj-207	49	6	in	in	ADP
arestyrurj-207	49	7	pbs	pbs	PROPN
arestyrurj-207	49	8	,	,	PUNCT
arestyrurj-207	49	9	cut	cut	VERB
arestyrurj-207	49	10	into	into	ADP
arestyrurj-207	49	11	¼	¼	NOUN
arestyrurj-207	49	12	inch	inch	NOUN
arestyrurj-207	49	13	pieces	piece	NOUN
arestyrurj-207	49	14	,	,	PUNCT
arestyrurj-207	49	15	and	and	CCONJ
arestyrurj-207	49	16	rotated	rotate	VERB
arestyrurj-207	49	17	in	in	ADP
arestyrurj-207	49	18	3	3	NUM
arestyrurj-207	49	19	mm	mm	NOUN
arestyrurj-207	49	20	edta	edta	NOUN
arestyrurj-207	49	21	for	for	ADP
arestyrurj-207	49	22	5	5	NUM
arestyrurj-207	49	23	,	,	PUNCT
arestyrurj-207	49	24	10	10	NUM
arestyrurj-207	49	25	,	,	PUNCT
arestyrurj-207	49	26	and	and	CCONJ
arestyrurj-207	49	27	20	20	NUM
arestyrurj-207	49	28	minutes	minute	NOUN
arestyrurj-207	49	29	(	(	PUNCT
arestyrurj-207	49	30	each	each	DET
arestyrurj-207	49	31	time	time	NOUN
arestyrurj-207	49	32	aresty	aresty	PROPN
arestyrurj-207	49	33	rutgers	rutgers	PROPN
arestyrurj-207	49	34	undergraduate	undergraduate	PROPN
arestyrurj-207	49	35	research	research	PROPN
arestyrurj-207	49	36	journal	journal	PROPN
arestyrurj-207	49	37	,	,	PUNCT
arestyrurj-207	49	38	volume	volume	NOUN
arestyrurj-207	49	39	i	i	PRON
arestyrurj-207	49	40	,	,	PUNCT
arestyrurj-207	49	41	issue	issue	NOUN
arestyrurj-207	49	42	iv	iv	PRON
arestyrurj-207	49	43	replace	replace	VERB
arestyrurj-207	49	44	the	the	DET
arestyrurj-207	49	45	edta	edta	NOUN
arestyrurj-207	49	46	)	)	PUNCT
arestyrurj-207	49	47	.	.	PUNCT
arestyrurj-207	50	1	tissues	tissue	NOUN
arestyrurj-207	50	2	are	be	AUX
arestyrurj-207	50	3	then	then	ADV
arestyrurj-207	50	4	agitated	agitate	VERB
arestyrurj-207	50	5	and	and	CCONJ
arestyrurj-207	50	6	filtered	filter	VERB
arestyrurj-207	50	7	through	through	ADP
arestyrurj-207	50	8	a	a	DET
arestyrurj-207	50	9	70μm	70μm	ADJ
arestyrurj-207	50	10	filter	filter	NOUN
arestyrurj-207	50	11	for	for	ADP
arestyrurj-207	50	12	crypt	crypt	NOUN
arestyrurj-207	50	13	enrichment	enrichment	NOUN
arestyrurj-207	50	14	.	.	PUNCT
arestyrurj-207	51	1	crypts	crypt	NOUN
arestyrurj-207	51	2	are	be	AUX
arestyrurj-207	51	3	then	then	ADV
arestyrurj-207	51	4	washed	wash	VERB
arestyrurj-207	51	5	in	in	ADP
arestyrurj-207	51	6	pbs	pbs	PROPN
arestyrurj-207	51	7	and	and	CCONJ
arestyrurj-207	51	8	the	the	DET
arestyrurj-207	51	9	pellet	pellet	NOUN
arestyrurj-207	51	10	is	be	AUX
arestyrurj-207	51	11	resuspended	resuspend	VERB
arestyrurj-207	51	12	in	in	ADP
arestyrurj-207	51	13	bme	bme	NOUN
arestyrurj-207	51	14	-	-	PUNCT
arestyrurj-207	51	15	r1	r1	NOUN
arestyrurj-207	51	16	.	.	PUNCT
arestyrurj-207	52	1	media	medium	NOUN
arestyrurj-207	52	2	for	for	ADP
arestyrurj-207	52	3	the	the	DET
arestyrurj-207	52	4	crypts	crypt	NOUN
arestyrurj-207	52	5	include	include	VERB
arestyrurj-207	52	6	advanced	advanced	ADJ
arestyrurj-207	52	7	dmem	dmem	VERB
arestyrurj-207	52	8	supplemented	supplement	VERB
arestyrurj-207	52	9	with	with	ADP
arestyrurj-207	52	10	glutamax	glutamax	ADJ
arestyrurj-207	52	11	(	(	PUNCT
arestyrurj-207	52	12	auxiliary	auxiliary	ADJ
arestyrurj-207	52	13	energy	energy	NOUN
arestyrurj-207	52	14	source	source	NOUN
arestyrurj-207	52	15	for	for	ADP
arestyrurj-207	52	16	rapidly	rapidly	ADV
arestyrurj-207	52	17	dividing	divide	VERB
arestyrurj-207	52	18	cells	cell	NOUN
arestyrurj-207	52	19	)	)	PUNCT
arestyrurj-207	52	20	,	,	PUNCT
arestyrurj-207	52	21	hepes	hepe	NOUN
arestyrurj-207	52	22	(	(	PUNCT
arestyrurj-207	52	23	used	use	VERB
arestyrurj-207	52	24	to	to	PART
arestyrurj-207	52	25	maintain	maintain	VERB
arestyrurj-207	52	26	ph	ph	NOUN
arestyrurj-207	52	27	)	)	PUNCT
arestyrurj-207	52	28	,	,	PUNCT
arestyrurj-207	52	29	egf	egf	PROPN
arestyrurj-207	52	30	(	(	PUNCT
arestyrurj-207	52	31	epidermal	epidermal	ADJ
arestyrurj-207	52	32	growth	growth	NOUN
arestyrurj-207	52	33	factor	factor	NOUN
arestyrurj-207	52	34	:	:	PUNCT
arestyrurj-207	52	35	involved	involve	VERB
arestyrurj-207	52	36	with	with	ADP
arestyrurj-207	52	37	cell	cell	NOUN
arestyrurj-207	52	38	signaling	signal	VERB
arestyrurj-207	52	39	pathway	pathway	NOUN
arestyrurj-207	52	40	controlling	control	VERB
arestyrurj-207	52	41	cell	cell	NOUN
arestyrurj-207	52	42	division	division	NOUN
arestyrurj-207	52	43	)	)	PUNCT
arestyrurj-207	52	44	,	,	PUNCT
arestyrurj-207	52	45	noggin	noggin	NOUN
arestyrurj-207	52	46	(	(	PUNCT
arestyrurj-207	52	47	prevents	prevent	VERB
arestyrurj-207	52	48	cell	cell	NOUN
arestyrurj-207	52	49	differentiation	differentiation	NOUN
arestyrurj-207	52	50	)	)	PUNCT
arestyrurj-207	52	51	,	,	PUNCT
arestyrurj-207	52	52	nac	nac	PROPN
arestyrurj-207	52	53	(	(	PUNCT
arestyrurj-207	52	54	n	n	CCONJ
arestyrurj-207	52	55	-	-	PUNCT
arestyrurj-207	52	56	acetylcysteine	acetylcysteine	NOUN
arestyrurj-207	52	57	:	:	PUNCT
arestyrurj-207	52	58	protects	protect	VERB
arestyrurj-207	52	59	against	against	ADP
arestyrurj-207	52	60	rise	rise	NOUN
arestyrurj-207	52	61	of	of	ADP
arestyrurj-207	52	62	internal	internal	ADJ
arestyrurj-207	52	63	oxidant	oxidant	ADJ
arestyrurj-207	52	64	levels	level	NOUN
arestyrurj-207	52	65	)	)	PUNCT
arestyrurj-207	52	66	,	,	PUNCT
arestyrurj-207	52	67	n2	n2	NOUN
arestyrurj-207	52	68	(	(	PUNCT
arestyrurj-207	52	69	promotes	promote	VERB
arestyrurj-207	52	70	in	in	ADP
arestyrurj-207	52	71	vitro	vitro	X
arestyrurj-207	52	72	differentiation	differentiation	NOUN
arestyrurj-207	52	73	of	of	ADP
arestyrurj-207	52	74	stem	stem	NOUN
arestyrurj-207	52	75	cells	cell	NOUN
arestyrurj-207	52	76	)	)	PUNCT
arestyrurj-207	52	77	,	,	PUNCT
arestyrurj-207	52	78	b27	b27	PROPN
arestyrurj-207	52	79	(	(	PUNCT
arestyrurj-207	52	80	promotes	promote	VERB
arestyrurj-207	52	81	growth	growth	NOUN
arestyrurj-207	52	82	and	and	CCONJ
arestyrurj-207	52	83	proliferation	proliferation	NOUN
arestyrurj-207	52	84	,	,	PUNCT
arestyrurj-207	52	85	but	but	CCONJ
arestyrurj-207	52	86	not	not	PART
arestyrurj-207	52	87	differentiation	differentiation	NOUN
arestyrurj-207	52	88	)	)	PUNCT
arestyrurj-207	52	89	,	,	PUNCT
arestyrurj-207	52	90	rspo	rspo	NOUN
arestyrurj-207	52	91	(	(	PUNCT
arestyrurj-207	52	92	positively	positively	ADV
arestyrurj-207	52	93	regulates	regulate	VERB
arestyrurj-207	52	94	wnt	wnt	PROPN
arestyrurj-207	52	95	/	/	SYM
arestyrurj-207	52	96	beta	beta	NOUN
arestyrurj-207	52	97	-	-	PUNCT
arestyrurj-207	52	98	catenin	catenin	NOUN
arestyrurj-207	52	99	signaling	signaling	NOUN
arestyrurj-207	52	100	,	,	PUNCT
arestyrurj-207	52	101	which	which	PRON
arestyrurj-207	52	102	induces	induce	VERB
arestyrurj-207	52	103	proliferation	proliferation	NOUN
arestyrurj-207	52	104	)	)	PUNCT
arestyrurj-207	52	105	,	,	PUNCT
arestyrurj-207	52	106	and	and	CCONJ
arestyrurj-207	52	107	pen	pen	NOUN
arestyrurj-207	52	108	-	-	PUNCT
arestyrurj-207	52	109	strep	strep	NOUN
arestyrurj-207	52	110	(	(	PUNCT
arestyrurj-207	52	111	prevents	prevent	VERB
arestyrurj-207	52	112	bacterial	bacterial	ADJ
arestyrurj-207	52	113	contamination	contamination	NOUN
arestyrurj-207	52	114	)	)	PUNCT
arestyrurj-207	52	115	.	.	PUNCT
arestyrurj-207	53	1	after	after	ADP
arestyrurj-207	53	2	3	3	NUM
arestyrurj-207	53	3	days	day	NOUN
arestyrurj-207	53	4	of	of	ADP
arestyrurj-207	53	5	organoids	organoid	NOUN
arestyrurj-207	53	6	being	be	AUX
arestyrurj-207	53	7	treated	treat	VERB
arestyrurj-207	53	8	with	with	ADP
arestyrurj-207	53	9	this	this	DET
arestyrurj-207	53	10	media	medium	NOUN
arestyrurj-207	53	11	,	,	PUNCT
arestyrurj-207	53	12	it	it	PRON
arestyrurj-207	53	13	becomes	become	VERB
arestyrurj-207	53	14	conditioned	conditioned	ADJ
arestyrurj-207	53	15	media	medium	NOUN
arestyrurj-207	53	16	(	(	PUNCT
arestyrurj-207	53	17	contains	contain	VERB
arestyrurj-207	53	18	ligands	ligand	NOUN
arestyrurj-207	53	19	excreted	excrete	VERB
arestyrurj-207	53	20	by	by	ADP
arestyrurj-207	53	21	epithelium	epithelium	NOUN
arestyrurj-207	53	22	)	)	PUNCT
arestyrurj-207	53	23	.	.	PUNCT
arestyrurj-207	54	1	genotyping	genotype	VERB
arestyrurj-207	54	2	mice	mouse	NOUN
arestyrurj-207	54	3	toes	toe	NOUN
arestyrurj-207	54	4	are	be	AUX
arestyrurj-207	54	5	clipped	clip	VERB
arestyrurj-207	54	6	and	and	CCONJ
arestyrurj-207	54	7	used	use	VERB
arestyrurj-207	54	8	as	as	ADP
arestyrurj-207	54	9	a	a	DET
arestyrurj-207	54	10	source	source	NOUN
arestyrurj-207	54	11	for	for	ADP
arestyrurj-207	54	12	dna	dna	NOUN
arestyrurj-207	54	13	genotyping	genotype	VERB
arestyrurj-207	54	14	analysis	analysis	NOUN
arestyrurj-207	54	15	.	.	PUNCT
arestyrurj-207	55	1	dna	dna	PROPN
arestyrurj-207	55	2	is	be	AUX
arestyrurj-207	55	3	extracted	extract	VERB
arestyrurj-207	55	4	using	use	VERB
arestyrurj-207	55	5	the	the	DET
arestyrurj-207	55	6	kappa	kappa	ADJ
arestyrurj-207	55	7	buffer	buffer	PROPN
arestyrurj-207	55	8	qiagen	qiagen	PROPN
arestyrurj-207	55	9	kit	kit	NOUN
arestyrurj-207	55	10	followed	follow	VERB
arestyrurj-207	55	11	by	by	ADP
arestyrurj-207	55	12	pcr	pcr	NOUN
arestyrurj-207	55	13	for	for	ADP
arestyrurj-207	55	14	amplification	amplification	NOUN
arestyrurj-207	55	15	.	.	PUNCT
arestyrurj-207	56	1	genotypes	genotype	NOUN
arestyrurj-207	56	2	are	be	AUX
arestyrurj-207	56	3	confirmed	confirm	VERB
arestyrurj-207	56	4	by	by	ADP
arestyrurj-207	56	5	dna	dna	PROPN
arestyrurj-207	56	6	electrophoresis	electrophoresis	NOUN
arestyrurj-207	56	7	.	.	PUNCT
arestyrurj-207	57	1	hematoxylin	hematoxylin	NOUN
arestyrurj-207	57	2	and	and	CCONJ
arestyrurj-207	57	3	eosin	eosin	NOUN
arestyrurj-207	57	4	staining	stain	VERB
arestyrurj-207	57	5	to	to	PART
arestyrurj-207	57	6	understand	understand	VERB
arestyrurj-207	57	7	the	the	DET
arestyrurj-207	57	8	changes	change	NOUN
arestyrurj-207	57	9	in	in	ADP
arestyrurj-207	57	10	the	the	DET
arestyrurj-207	57	11	epithelial	epithelial	ADJ
arestyrurj-207	57	12	architecture	architecture	NOUN
arestyrurj-207	57	13	in	in	ADP
arestyrurj-207	57	14	terms	term	NOUN
arestyrurj-207	57	15	of	of	ADP
arestyrurj-207	57	16	the	the	DET
arestyrurj-207	57	17	formation	formation	NOUN
arestyrurj-207	57	18	of	of	ADP
arestyrurj-207	57	19	crypt	crypt	NOUN
arestyrurj-207	57	20	progenitor	progenitor	NOUN
arestyrurj-207	57	21	cell	cell	NOUN
arestyrurj-207	57	22	phenotype	phenotype	NOUN
arestyrurj-207	57	23	(	(	PUNCT
arestyrurj-207	57	24	cpc	cpc	PROPN
arestyrurj-207	57	25	)	)	PUNCT
arestyrurj-207	57	26	,	,	PUNCT
arestyrurj-207	57	27	we	we	PRON
arestyrurj-207	57	28	conducted	conduct	VERB
arestyrurj-207	57	29	h&e	h&e	PROPN
arestyrurj-207	57	30	histological	histological	ADJ
arestyrurj-207	57	31	analysis	analysis	NOUN
arestyrurj-207	57	32	.	.	PUNCT
arestyrurj-207	58	1	tissues	tissue	NOUN
arestyrurj-207	58	2	are	be	AUX
arestyrurj-207	58	3	initially	initially	ADV
arestyrurj-207	58	4	washed	wash	VERB
arestyrurj-207	58	5	in	in	ADP
arestyrurj-207	58	6	xylene	xylene	NOUN
arestyrurj-207	58	7	twice	twice	ADV
arestyrurj-207	58	8	(	(	PUNCT
arestyrurj-207	58	9	5	5	NUM
arestyrurj-207	58	10	min	min	NOUN
arestyrurj-207	58	11	each	each	PRON
arestyrurj-207	58	12	)	)	PUNCT
arestyrurj-207	58	13	.	.	PUNCT
arestyrurj-207	59	1	then	then	ADV
arestyrurj-207	59	2	tissues	tissue	NOUN
arestyrurj-207	59	3	go	go	VERB
arestyrurj-207	59	4	through	through	ADP
arestyrurj-207	59	5	two	two	NUM
arestyrurj-207	59	6	consecutive	consecutive	ADJ
arestyrurj-207	59	7	100	100	NUM
arestyrurj-207	59	8	%	%	NOUN
arestyrurj-207	59	9	etoh	etoh	NOUN
arestyrurj-207	59	10	washes	wash	NOUN
arestyrurj-207	59	11	(	(	PUNCT
arestyrurj-207	59	12	5	5	NUM
arestyrurj-207	59	13	min	min	NOUN
arestyrurj-207	59	14	each	each	PRON
arestyrurj-207	59	15	)	)	PUNCT
arestyrurj-207	59	16	,	,	PUNCT
arestyrurj-207	59	17	followed	follow	VERB
arestyrurj-207	59	18	by	by	ADP
arestyrurj-207	59	19	a	a	DET
arestyrurj-207	59	20	3	3	NUM
arestyrurj-207	59	21	min	min	NOUN
arestyrurj-207	59	22	95	95	NUM
arestyrurj-207	59	23	%	%	NOUN
arestyrurj-207	59	24	etoh	etoh	NOUN
arestyrurj-207	59	25	wash	wash	NOUN
arestyrurj-207	59	26	,	,	PUNCT
arestyrurj-207	59	27	a	a	DET
arestyrurj-207	59	28	3	3	NUM
arestyrurj-207	59	29	min	min	NOUN
arestyrurj-207	59	30	85	85	NUM
arestyrurj-207	59	31	%	%	NOUN
arestyrurj-207	59	32	etoh	etoh	NOUN
arestyrurj-207	59	33	wash	wash	NOUN
arestyrurj-207	59	34	,	,	PUNCT
arestyrurj-207	59	35	a	a	DET
arestyrurj-207	59	36	3	3	NUM
arestyrurj-207	59	37	min	min	NOUN
arestyrurj-207	59	38	70	70	NUM
arestyrurj-207	59	39	%	%	NOUN
arestyrurj-207	59	40	etoh	etoh	NOUN
arestyrurj-207	59	41	wash	wash	NOUN
arestyrurj-207	59	42	,	,	PUNCT
arestyrurj-207	59	43	and	and	CCONJ
arestyrurj-207	59	44	a	a	DET
arestyrurj-207	59	45	5	5	NUM
arestyrurj-207	59	46	min	min	NOUN
arestyrurj-207	59	47	double	double	ADV
arestyrurj-207	59	48	-	-	PUNCT
arestyrurj-207	59	49	distilled	distil	VERB
arestyrurj-207	59	50	water	water	NOUN
arestyrurj-207	59	51	wash	wash	NOUN
arestyrurj-207	59	52	.	.	PUNCT
arestyrurj-207	60	1	unstained	unstaine	VERB
arestyrurj-207	60	2	sections	section	NOUN
arestyrurj-207	60	3	of	of	ADP
arestyrurj-207	60	4	mouse	mouse	NOUN
arestyrurj-207	60	5	duodenum	duodenum	NOUN
arestyrurj-207	60	6	are	be	AUX
arestyrurj-207	60	7	stained	stain	VERB
arestyrurj-207	60	8	with	with	ADP
arestyrurj-207	60	9	hematoxylin	hematoxylin	PROPN
arestyrurj-207	60	10	(	(	PUNCT
arestyrurj-207	60	11	30	30	NUM
arestyrurj-207	60	12	seconds	second	NOUN
arestyrurj-207	60	13	)	)	PUNCT
arestyrurj-207	60	14	and	and	CCONJ
arestyrurj-207	60	15	dehydrated	dehydrate	VERB
arestyrurj-207	60	16	by	by	ADP
arestyrurj-207	60	17	dipping	dip	VERB
arestyrurj-207	60	18	in	in	ADP
arestyrurj-207	60	19	water	water	NOUN
arestyrurj-207	60	20	,	,	PUNCT
arestyrurj-207	60	21	followed	follow	VERB
arestyrurj-207	60	22	by	by	ADP
arestyrurj-207	60	23	increasing	increase	VERB
arestyrurj-207	60	24	alcohol	alcohol	NOUN
arestyrurj-207	60	25	percentages	percentage	NOUN
arestyrurj-207	60	26	.	.	PUNCT
arestyrurj-207	61	1	tissues	tissue	NOUN
arestyrurj-207	61	2	are	be	AUX
arestyrurj-207	61	3	then	then	ADV
arestyrurj-207	61	4	counterstained	counterstaine	VERB
arestyrurj-207	61	5	with	with	ADP
arestyrurj-207	61	6	eosin	eosin	NOUN
arestyrurj-207	61	7	for	for	ADP
arestyrurj-207	61	8	1	1	NUM
arestyrurj-207	61	9	minute	minute	NOUN
arestyrurj-207	61	10	(	(	PUNCT
arestyrurj-207	61	11	eosin	eosin	NOUN
arestyrurj-207	61	12	in	in	ADP
arestyrurj-207	61	13	counterstain	counterstain	NOUN
arestyrurj-207	61	14	,	,	PUNCT
arestyrurj-207	61	15	which	which	PRON
arestyrurj-207	61	16	distinguishes	distinguish	VERB
arestyrurj-207	61	17	between	between	ADP
arestyrurj-207	61	18	cytoplasm	cytoplasm	NOUN
arestyrurj-207	61	19	and	and	CCONJ
arestyrurj-207	61	20	nuclei	nucleus	NOUN
arestyrurj-207	61	21	)	)	PUNCT
arestyrurj-207	61	22	.	.	PUNCT
arestyrurj-207	62	1	rna	rna	PROPN
arestyrurj-207	62	2	/	/	SYM
arestyrurj-207	62	3	dna	dna	PROPN
arestyrurj-207	62	4	preparation	preparation	NOUN
arestyrurj-207	62	5	and	and	CCONJ
arestyrurj-207	62	6	qpcr	qpcr	ADV
arestyrurj-207	62	7	mesenchyme	mesenchyme	NOUN
arestyrurj-207	62	8	cells	cell	NOUN
arestyrurj-207	62	9	are	be	AUX
arestyrurj-207	62	10	dissolved	dissolve	VERB
arestyrurj-207	62	11	in	in	ADP
arestyrurj-207	62	12	trizol	trizol	NOUN
arestyrurj-207	62	13	.	.	PUNCT
arestyrurj-207	63	1	rna	rna	NOUN
arestyrurj-207	63	2	is	be	AUX
arestyrurj-207	63	3	prepared	prepare	VERB
arestyrurj-207	63	4	according	accord	VERB
arestyrurj-207	63	5	to	to	ADP
arestyrurj-207	63	6	the	the	DET
arestyrurj-207	63	7	manufacturer	manufacturer	NOUN
arestyrurj-207	63	8	’s	’s	PART
arestyrurj-207	63	9	protocols	protocol	NOUN
arestyrurj-207	63	10	.	.	PUNCT
arestyrurj-207	64	1	the	the	DET
arestyrurj-207	64	2	rna	rna	NOUN
arestyrurj-207	64	3	is	be	AUX
arestyrurj-207	64	4	then	then	ADV
arestyrurj-207	64	5	reverse	reverse	VERB
arestyrurj-207	64	6	transcribed	transcribe	VERB
arestyrurj-207	64	7	to	to	ADP
arestyrurj-207	64	8	cdna	cdna	PROPN
arestyrurj-207	64	9	using	use	VERB
arestyrurj-207	64	10	superscript	superscript	PROPN
arestyrurj-207	64	11	iii	iii	PROPN
arestyrurj-207	64	12	first	first	ADJ
arestyrurj-207	64	13	-	-	PUNCT
arestyrurj-207	64	14	strand	strand	NOUN
arestyrurj-207	64	15	synthesis	synthesis	NOUN
arestyrurj-207	64	16	system	system	NOUN
arestyrurj-207	64	17	.	.	PUNCT
arestyrurj-207	65	1	sybr	sybr	PROPN
arestyrurj-207	65	2	green	green	PROPN
arestyrurj-207	65	3	is	be	AUX
arestyrurj-207	65	4	used	use	VERB
arestyrurj-207	65	5	to	to	PART
arestyrurj-207	65	6	amplify	amplify	VERB
arestyrurj-207	65	7	the	the	DET
arestyrurj-207	65	8	cdna	cdna	PROPN
arestyrurj-207	65	9	through	through	ADP
arestyrurj-207	65	10	qpcr	qpcr	ADJ
arestyrurj-207	65	11	analysis	analysis	NOUN
arestyrurj-207	65	12	.	.	PUNCT
arestyrurj-207	66	1	vimentin	vimentin	NOUN
arestyrurj-207	66	2	is	be	AUX
arestyrurj-207	66	3	used	use	VERB
arestyrurj-207	66	4	for	for	ADP
arestyrurj-207	66	5	normalization	normalization	NOUN
arestyrurj-207	66	6	.	.	PUNCT
arestyrurj-207	67	1	mesenchyme	mesenchyme	VERB
arestyrurj-207	67	2	treatment	treatment	NOUN
arestyrurj-207	67	3	with	with	ADP
arestyrurj-207	67	4	conditioned	condition	VERB
arestyrurj-207	67	5	media	medium	NOUN
arestyrurj-207	67	6	the	the	DET
arestyrurj-207	67	7	main	main	ADJ
arestyrurj-207	67	8	experiment	experiment	NOUN
arestyrurj-207	67	9	consists	consist	VERB
arestyrurj-207	67	10	of	of	ADP
arestyrurj-207	67	11	using	use	VERB
arestyrurj-207	67	12	mesenchyme	mesenchyme	NOUN
arestyrurj-207	67	13	cells	cell	NOUN
arestyrurj-207	67	14	and	and	CCONJ
arestyrurj-207	67	15	treating	treat	VERB
arestyrurj-207	67	16	them	they	PRON
arestyrurj-207	67	17	with	with	ADP
arestyrurj-207	67	18	(	(	PUNCT
arestyrurj-207	67	19	1	1	X
arestyrurj-207	67	20	)	)	PUNCT
arestyrurj-207	67	21	conditioned	condition	VERB
arestyrurj-207	67	22	media	medium	NOUN
arestyrurj-207	67	23	from	from	ADP
arestyrurj-207	67	24	mutant	mutant	ADJ
arestyrurj-207	67	25	organoids	organoid	NOUN
arestyrurj-207	67	26	treated	treat	VERB
arestyrurj-207	67	27	with	with	ADP
arestyrurj-207	67	28	ccm	ccm	PROPN
arestyrurj-207	67	29	,	,	PUNCT
arestyrurj-207	67	30	(	(	PUNCT
arestyrurj-207	67	31	2	2	X
arestyrurj-207	67	32	)	)	PUNCT
arestyrurj-207	67	33	mutant	mutant	ADJ
arestyrurj-207	67	34	organoids	organoid	NOUN
arestyrurj-207	67	35	treated	treat	VERB
arestyrurj-207	67	36	with	with	ADP
arestyrurj-207	67	37	mesenchyme	mesenchyme	NOUN
arestyrurj-207	67	38	media	medium	NOUN
arestyrurj-207	67	39	,	,	PUNCT
arestyrurj-207	67	40	(	(	PUNCT
arestyrurj-207	67	41	3	3	X
arestyrurj-207	67	42	)	)	PUNCT
arestyrurj-207	67	43	wild	wild	ADJ
arestyrurj-207	67	44	type	type	NOUN
arestyrurj-207	67	45	organoids	organoid	NOUN
arestyrurj-207	67	46	treated	treat	VERB
arestyrurj-207	67	47	with	with	ADP
arestyrurj-207	67	48	ccm	ccm	NOUN
arestyrurj-207	67	49	,	,	PUNCT
arestyrurj-207	67	50	and	and	CCONJ
arestyrurj-207	67	51	(	(	PUNCT
arestyrurj-207	67	52	4	4	X
arestyrurj-207	67	53	)	)	PUNCT
arestyrurj-207	67	54	mesenchyme	mesenchyme	NOUN
arestyrurj-207	67	55	media	medium	NOUN
arestyrurj-207	67	56	as	as	ADP
arestyrurj-207	67	57	a	a	DET
arestyrurj-207	67	58	control	control	NOUN
arestyrurj-207	67	59	.	.	PUNCT
arestyrurj-207	68	1	to	to	PART
arestyrurj-207	68	2	demonstrate	demonstrate	VERB
arestyrurj-207	68	3	the	the	DET
arestyrurj-207	68	4	response	response	NOUN
arestyrurj-207	68	5	by	by	ADP
arestyrurj-207	68	6	the	the	DET
arestyrurj-207	68	7	mesenchyme	mesenchyme	NOUN
arestyrurj-207	68	8	,	,	PUNCT
arestyrurj-207	68	9	changes	change	NOUN
arestyrurj-207	68	10	in	in	ADP
arestyrurj-207	68	11	ligand	ligand	ADJ
arestyrurj-207	68	12	expression	expression	NOUN
arestyrurj-207	68	13	are	be	AUX
arestyrurj-207	68	14	examined	examine	VERB
arestyrurj-207	68	15	among	among	ADP
arestyrurj-207	68	16	treatment	treatment	NOUN
arestyrurj-207	68	17	groups	group	NOUN
arestyrurj-207	68	18	.	.	PUNCT
arestyrurj-207	69	1	after	after	ADP
arestyrurj-207	69	2	passaging	passage	VERB
arestyrurj-207	69	3	mesenchyme	mesenchyme	NOUN
arestyrurj-207	69	4	cells	cell	NOUN
arestyrurj-207	69	5	,	,	PUNCT
arestyrurj-207	69	6	they	they	PRON
arestyrurj-207	69	7	are	be	AUX
arestyrurj-207	69	8	plated	plate	VERB
arestyrurj-207	69	9	,	,	PUNCT
arestyrurj-207	69	10	and	and	CCONJ
arestyrurj-207	69	11	are	be	AUX
arestyrurj-207	69	12	treated	treat	VERB
arestyrurj-207	69	13	with	with	ADP
arestyrurj-207	69	14	mesenchyme	mesenchyme	NOUN
arestyrurj-207	69	15	media	medium	NOUN
arestyrurj-207	69	16	on	on	ADP
arestyrurj-207	69	17	day	day	NOUN
arestyrurj-207	69	18	1	1	NUM
arestyrurj-207	69	19	.	.	PUNCT
arestyrurj-207	70	1	pictures	picture	NOUN
arestyrurj-207	70	2	of	of	ADP
arestyrurj-207	70	3	the	the	DET
arestyrurj-207	70	4	cells	cell	NOUN
arestyrurj-207	70	5	are	be	AUX
arestyrurj-207	70	6	taken	take	VERB
arestyrurj-207	70	7	on	on	ADP
arestyrurj-207	70	8	day	day	NOUN
arestyrurj-207	70	9	4	4	NUM
arestyrurj-207	70	10	,	,	PUNCT
arestyrurj-207	70	11	and	and	CCONJ
arestyrurj-207	70	12	the	the	DET
arestyrurj-207	70	13	media	medium	NOUN
arestyrurj-207	70	14	is	be	AUX
arestyrurj-207	70	15	aspirated	aspirate	VERB
arestyrurj-207	70	16	and	and	CCONJ
arestyrurj-207	70	17	replaced	replace	VERB
arestyrurj-207	70	18	with	with	ADP
arestyrurj-207	70	19	conditioned	condition	VERB
arestyrurj-207	70	20	media	medium	NOUN
arestyrurj-207	70	21	or	or	CCONJ
arestyrurj-207	70	22	mesenchyme	mesenchyme	NOUN
arestyrurj-207	70	23	media	medium	NOUN
arestyrurj-207	70	24	for	for	ADP
arestyrurj-207	70	25	control	control	NOUN
arestyrurj-207	70	26	.	.	PUNCT
arestyrurj-207	71	1	the	the	DET
arestyrurj-207	71	2	plate	plate	NOUN
arestyrurj-207	71	3	consists	consist	VERB
arestyrurj-207	71	4	of	of	ADP
arestyrurj-207	71	5	4	4	NUM
arestyrurj-207	71	6	rows	row	NOUN
arestyrurj-207	71	7	and	and	CCONJ
arestyrurj-207	71	8	3	3	NUM
arestyrurj-207	71	9	columns	column	NOUN
arestyrurj-207	71	10	;	;	PUNCT
arestyrurj-207	71	11	rows	row	NOUN
arestyrurj-207	71	12	1	1	NUM
arestyrurj-207	71	13	and	and	CCONJ
arestyrurj-207	71	14	2	2	NUM
arestyrurj-207	71	15	are	be	AUX
arestyrurj-207	71	16	made	make	VERB
arestyrurj-207	71	17	up	up	ADP
arestyrurj-207	71	18	of	of	ADP
arestyrurj-207	71	19	a	a	DET
arestyrurj-207	71	20	confluent	confluent	ADJ
arestyrurj-207	71	21	wild	wild	ADJ
arestyrurj-207	71	22	-	-	PUNCT
arestyrurj-207	71	23	type	type	NOUN
arestyrurj-207	71	24	mesenchyme	mesenchyme	NOUN
arestyrurj-207	71	25	cells	cell	NOUN
arestyrurj-207	71	26	,	,	PUNCT
arestyrurj-207	71	27	and	and	CCONJ
arestyrurj-207	71	28	row	row	VERB
arestyrurj-207	71	29	3	3	NUM
arestyrurj-207	71	30	consists	consist	NOUN
arestyrurj-207	71	31	of	of	ADP
arestyrurj-207	71	32	sub	sub	ADJ
arestyrurj-207	71	33	-	-	ADJ
arestyrurj-207	71	34	confluent	confluent	ADJ
arestyrurj-207	71	35	wild	wild	ADJ
arestyrurj-207	71	36	type	type	NOUN
arestyrurj-207	71	37	mesenchyme	mesenchyme	NOUN
arestyrurj-207	71	38	cells	cell	NOUN
arestyrurj-207	71	39	.	.	PUNCT
arestyrurj-207	72	1	samples	sample	NOUN
arestyrurj-207	72	2	in	in	ADP
arestyrurj-207	72	3	the	the	DET
arestyrurj-207	72	4	first	first	ADJ
arestyrurj-207	72	5	column	column	NOUN
arestyrurj-207	72	6	serve	serve	VERB
arestyrurj-207	72	7	as	as	ADP
arestyrurj-207	72	8	controls	control	NOUN
arestyrurj-207	72	9	and	and	CCONJ
arestyrurj-207	72	10	are	be	AUX
arestyrurj-207	72	11	treated	treat	VERB
arestyrurj-207	72	12	with	with	ADP
arestyrurj-207	72	13	mesenchyme	mesenchyme	NOUN
arestyrurj-207	72	14	media	medium	NOUN
arestyrurj-207	72	15	,	,	PUNCT
arestyrurj-207	72	16	samples	sample	NOUN
arestyrurj-207	72	17	in	in	ADP
arestyrurj-207	72	18	the	the	DET
arestyrurj-207	72	19	second	second	ADJ
arestyrurj-207	72	20	column	column	NOUN
arestyrurj-207	72	21	are	be	AUX
arestyrurj-207	72	22	treated	treat	VERB
arestyrurj-207	72	23	with	with	ADP
arestyrurj-207	72	24	conditioned	condition	VERB
arestyrurj-207	72	25	ccm	ccm	NOUN
arestyrurj-207	72	26	from	from	ADP
arestyrurj-207	72	27	mutant	mutant	ADJ
arestyrurj-207	72	28	organoids	organoid	NOUN
arestyrurj-207	72	29	,	,	PUNCT
arestyrurj-207	72	30	samples	sample	NOUN
arestyrurj-207	72	31	in	in	ADP
arestyrurj-207	72	32	the	the	DET
arestyrurj-207	72	33	third	third	ADJ
arestyrurj-207	72	34	column	column	NOUN
arestyrurj-207	72	35	are	be	AUX
arestyrurj-207	72	36	treated	treat	VERB
arestyrurj-207	72	37	with	with	ADP
arestyrurj-207	72	38	conditioned	condition	VERB
arestyrurj-207	72	39	mesenchyme	mesenchyme	NOUN
arestyrurj-207	72	40	media	medium	NOUN
arestyrurj-207	72	41	from	from	ADP
arestyrurj-207	72	42	mutant	mutant	ADJ
arestyrurj-207	72	43	organoids	organoid	NOUN
arestyrurj-207	72	44	,	,	PUNCT
arestyrurj-207	72	45	and	and	CCONJ
arestyrurj-207	72	46	samples	sample	NOUN
arestyrurj-207	72	47	in	in	ADP
arestyrurj-207	72	48	the	the	DET
arestyrurj-207	72	49	fourth	fourth	ADJ
arestyrurj-207	72	50	column	column	NOUN
arestyrurj-207	72	51	are	be	AUX
arestyrurj-207	72	52	treated	treat	VERB
arestyrurj-207	72	53	with	with	ADP
arestyrurj-207	72	54	conditioned	condition	VERB
arestyrurj-207	72	55	ccm	ccm	NOUN
arestyrurj-207	72	56	from	from	ADP
arestyrurj-207	72	57	wild	wild	ADJ
arestyrurj-207	72	58	type	type	NOUN
arestyrurj-207	72	59	organoids	organoid	NOUN
arestyrurj-207	72	60	.	.	PUNCT
arestyrurj-207	73	1	the	the	DET
arestyrurj-207	73	2	fourth	fourth	ADJ
arestyrurj-207	73	3	column	column	NOUN
arestyrurj-207	73	4	is	be	AUX
arestyrurj-207	73	5	a	a	DET
arestyrurj-207	73	6	control	control	NOUN
arestyrurj-207	73	7	because	because	SCONJ
arestyrurj-207	73	8	the	the	DET
arestyrurj-207	73	9	wild	wild	ADJ
arestyrurj-207	73	10	type	type	NOUN
arestyrurj-207	73	11	organoids	organoid	NOUN
arestyrurj-207	73	12	do	do	AUX
arestyrurj-207	73	13	not	not	PART
arestyrurj-207	73	14	express	express	VERB
arestyrurj-207	73	15	mutant	mutant	ADJ
arestyrurj-207	73	16	growth	growth	NOUN
arestyrurj-207	73	17	,	,	PUNCT
arestyrurj-207	73	18	so	so	SCONJ
arestyrurj-207	73	19	we	we	PRON
arestyrurj-207	73	20	expect	expect	VERB
arestyrurj-207	73	21	there	there	PRON
arestyrurj-207	73	22	to	to	PART
arestyrurj-207	73	23	be	be	AUX
arestyrurj-207	73	24	no	no	DET
arestyrurj-207	73	25	change	change	NOUN
arestyrurj-207	73	26	in	in	ADP
arestyrurj-207	73	27	grem1	grem1	NOUN
arestyrurj-207	73	28	and	and	CCONJ
arestyrurj-207	73	29	wnt2b	wnt2b	PROPN
arestyrurj-207	73	30	expression	expression	NOUN
arestyrurj-207	73	31	.	.	PUNCT
arestyrurj-207	74	1	on	on	ADP
arestyrurj-207	74	2	day	day	NOUN
arestyrurj-207	74	3	6	6	NUM
arestyrurj-207	74	4	,	,	PUNCT
arestyrurj-207	74	5	the	the	DET
arestyrurj-207	74	6	cells	cell	NOUN
arestyrurj-207	74	7	are	be	AUX
arestyrurj-207	74	8	harvested	harvest	VERB
arestyrurj-207	74	9	with	with	ADP
arestyrurj-207	74	10	trizol	trizol	NOUN
arestyrurj-207	74	11	for	for	ADP
arestyrurj-207	74	12	rna	rna	NOUN
arestyrurj-207	74	13	isolation	isolation	NOUN
arestyrurj-207	74	14	,	,	PUNCT
arestyrurj-207	74	15	which	which	PRON
arestyrurj-207	74	16	is	be	AUX
arestyrurj-207	74	17	then	then	ADV
arestyrurj-207	74	18	converted	convert	VERB
arestyrurj-207	74	19	to	to	ADP
arestyrurj-207	74	20	cdna	cdna	PROPN
arestyrurj-207	74	21	.	.	PUNCT
arestyrurj-207	75	1	for	for	ADP
arestyrurj-207	75	2	this	this	DET
arestyrurj-207	75	3	experiment	experiment	NOUN
arestyrurj-207	75	4	we	we	PRON
arestyrurj-207	75	5	measure	measure	VERB
arestyrurj-207	75	6	11	11	NUM
arestyrurj-207	75	7	protein	protein	NOUN
arestyrurj-207	75	8	coding	code	VERB
arestyrurj-207	75	9	genes	gene	NOUN
arestyrurj-207	75	10	(	(	PUNCT
arestyrurj-207	75	11	bmp2	bmp2	ADJ
arestyrurj-207	75	12	,	,	PUNCT
arestyrurj-207	75	13	bmp3	bmp3	PROPN
arestyrurj-207	75	14	,	,	PUNCT
arestyrurj-207	75	15	bmp4	bmp4	NOUN
arestyrurj-207	75	16	,	,	PUNCT
arestyrurj-207	75	17	bmp5	bmp5	PROPN
arestyrurj-207	75	18	,	,	PUNCT
arestyrurj-207	75	19	bmp6	bmp6	PROPN
arestyrurj-207	75	20	,	,	PUNCT
arestyrurj-207	75	21	grem1	grem1	PROPN
arestyrurj-207	75	22	,	,	PUNCT
arestyrurj-207	75	23	wnt2b	wnt2b	PROPN
arestyrurj-207	75	24	,	,	PUNCT
arestyrurj-207	75	25	rspo1	rspo1	PROPN
arestyrurj-207	75	26	,	,	PUNCT
arestyrurj-207	75	27	rspo3	rspo3	NOUN
arestyrurj-207	75	28	,	,	PUNCT
arestyrurj-207	75	29	wnt5a	wnt5a	PROPN
arestyrurj-207	75	30	,	,	PUNCT
arestyrurj-207	75	31	and	and	CCONJ
arestyrurj-207	75	32	wnt4	wnt4	PROPN
arestyrurj-207	75	33	)	)	PUNCT
arestyrurj-207	75	34	using	use	VERB
arestyrurj-207	75	35	qpcr	qpcr	ADV
arestyrurj-207	75	36	and	and	CCONJ
arestyrurj-207	75	37	compare	compare	VERB
arestyrurj-207	75	38	their	their	PRON
arestyrurj-207	75	39	relative	relative	ADJ
arestyrurj-207	75	40	abundances	abundance	NOUN
arestyrurj-207	75	41	.	.	PUNCT
arestyrurj-207	76	1	aresty	aresty	PROPN
arestyrurj-207	76	2	rutgers	rutgers	PROPN
arestyrurj-207	76	3	undergraduate	undergraduate	PROPN
arestyrurj-207	76	4	research	research	PROPN
arestyrurj-207	76	5	journal	journal	PROPN
arestyrurj-207	76	6	,	,	PUNCT
arestyrurj-207	76	7	volume	volume	NOUN
arestyrurj-207	76	8	i	i	PRON
arestyrurj-207	76	9	,	,	PUNCT
arestyrurj-207	76	10	issue	issue	NOUN
arestyrurj-207	76	11	iv	iv	NUM
arestyrurj-207	76	12	3	3	NUM
arestyrurj-207	76	13	results	result	NOUN
arestyrurj-207	76	14	tissue	tissue	NOUN
arestyrurj-207	76	15	images	image	NOUN
arestyrurj-207	76	16	are	be	AUX
arestyrurj-207	76	17	taken	take	VERB
arestyrurj-207	76	18	at	at	ADP
arestyrurj-207	76	19	day	day	NOUN
arestyrurj-207	76	20	10	10	NUM
arestyrurj-207	76	21	posttamoxifen	posttamoxifen	NOUN
arestyrurj-207	76	22	treatment	treatment	NOUN
arestyrurj-207	76	23	and	and	CCONJ
arestyrurj-207	76	24	stained	stain	VERB
arestyrurj-207	76	25	using	use	VERB
arestyrurj-207	76	26	hematoxylin	hematoxylin	NOUN
arestyrurj-207	76	27	and	and	CCONJ
arestyrurj-207	76	28	eosin	eosin	NOUN
arestyrurj-207	76	29	.	.	PUNCT
arestyrurj-207	77	1	figure	figure	NOUN
arestyrurj-207	77	2	1	1	NUM
arestyrurj-207	77	3	shows	show	VERB
arestyrurj-207	77	4	the	the	DET
arestyrurj-207	77	5	histology	histology	NOUN
arestyrurj-207	77	6	of	of	ADP
arestyrurj-207	77	7	the	the	DET
arestyrurj-207	77	8	control	control	NOUN
arestyrurj-207	77	9	and	and	CCONJ
arestyrurj-207	77	10	mutant	mutant	ADJ
arestyrurj-207	77	11	epithelium	epithelium	NOUN
arestyrurj-207	77	12	.	.	PUNCT
arestyrurj-207	78	1	the	the	DET
arestyrurj-207	78	2	control	control	NOUN
arestyrurj-207	78	3	and	and	CCONJ
arestyrurj-207	78	4	mutant	mutant	ADJ
arestyrurj-207	78	5	epithelium	epithelium	NOUN
arestyrurj-207	78	6	for	for	ADP
arestyrurj-207	78	7	replicates	replicate	NOUN
arestyrurj-207	78	8	1	1	NUM
arestyrurj-207	78	9	and	and	CCONJ
arestyrurj-207	78	10	2	2	NUM
arestyrurj-207	78	11	show	show	VERB
arestyrurj-207	78	12	little	little	ADJ
arestyrurj-207	78	13	difference	difference	NOUN
arestyrurj-207	78	14	in	in	ADP
arestyrurj-207	78	15	terms	term	NOUN
arestyrurj-207	78	16	of	of	ADP
arestyrurj-207	78	17	transformation	transformation	NOUN
arestyrurj-207	78	18	.	.	PUNCT
arestyrurj-207	79	1	this	this	PRON
arestyrurj-207	79	2	demonstrates	demonstrate	VERB
arestyrurj-207	79	3	the	the	DET
arestyrurj-207	79	4	delay	delay	NOUN
arestyrurj-207	79	5	stated	state	VERB
arestyrurj-207	79	6	before	before	ADV
arestyrurj-207	79	7	,	,	PUNCT
arestyrurj-207	79	8	suggesting	suggest	VERB
arestyrurj-207	79	9	that	that	SCONJ
arestyrurj-207	79	10	the	the	DET
arestyrurj-207	79	11	mesenchyme	mesenchyme	NOUN
arestyrurj-207	79	12	is	be	AUX
arestyrurj-207	79	13	playing	play	VERB
arestyrurj-207	79	14	a	a	DET
arestyrurj-207	79	15	role	role	NOUN
arestyrurj-207	79	16	to	to	PART
arestyrurj-207	79	17	suppress	suppress	VERB
arestyrurj-207	79	18	mutant	mutant	ADJ
arestyrurj-207	79	19	epithelial	epithelial	ADJ
arestyrurj-207	79	20	growth	growth	NOUN
arestyrurj-207	79	21	.	.	PUNCT
arestyrurj-207	80	1	to	to	PART
arestyrurj-207	80	2	understand	understand	VERB
arestyrurj-207	80	3	the	the	DET
arestyrurj-207	80	4	mesenchyme	mesenchyme	NOUN
arestyrurj-207	80	5	response	response	NOUN
arestyrurj-207	80	6	to	to	ADP
arestyrurj-207	80	7	ligands	ligand	NOUN
arestyrurj-207	80	8	secreted	secrete	VERB
arestyrurj-207	80	9	by	by	ADP
arestyrurj-207	80	10	mutant	mutant	ADJ
arestyrurj-207	80	11	epithelium	epithelium	NOUN
arestyrurj-207	80	12	,	,	PUNCT
arestyrurj-207	80	13	gene	gene	NOUN
arestyrurj-207	80	14	expression	expression	NOUN
arestyrurj-207	80	15	changes	change	NOUN
arestyrurj-207	80	16	are	be	AUX
arestyrurj-207	80	17	examined	examine	VERB
arestyrurj-207	80	18	following	follow	VERB
arestyrurj-207	80	19	treatment	treatment	NOUN
arestyrurj-207	80	20	with	with	ADP
arestyrurj-207	80	21	conditioned	condition	VERB
arestyrurj-207	80	22	media	medium	NOUN
arestyrurj-207	80	23	derived	derive	VERB
arestyrurj-207	80	24	from	from	ADP
arestyrurj-207	80	25	organoid	organoid	PROPN
arestyrurj-207	80	26	cultures	culture	NOUN
arestyrurj-207	80	27	.	.	PUNCT
arestyrurj-207	81	1	qpcr	qpcr	ADV
arestyrurj-207	81	2	(	(	PUNCT
arestyrurj-207	81	3	figure	figure	NOUN
arestyrurj-207	81	4	2a	2a	NUM
arestyrurj-207	81	5	and	and	CCONJ
arestyrurj-207	81	6	figure	figure	NOUN
arestyrurj-207	81	7	2b	2b	NOUN
arestyrurj-207	81	8	)	)	PUNCT
arestyrurj-207	81	9	analysis	analysis	NOUN
arestyrurj-207	81	10	demonstrated	demonstrate	VERB
arestyrurj-207	81	11	that	that	SCONJ
arestyrurj-207	81	12	confluent	confluent	ADJ
arestyrurj-207	81	13	and	and	CCONJ
arestyrurj-207	81	14	sub	sub	ADJ
arestyrurj-207	81	15	-	-	ADJ
arestyrurj-207	81	16	confluent	confluent	ADJ
arestyrurj-207	81	17	mesenchyme	mesenchyme	NOUN
arestyrurj-207	81	18	cells	cell	NOUN
arestyrurj-207	81	19	do	do	AUX
arestyrurj-207	81	20	not	not	PART
arestyrurj-207	81	21	respond	respond	VERB
arestyrurj-207	81	22	in	in	ADP
arestyrurj-207	81	23	the	the	DET
arestyrurj-207	81	24	same	same	ADJ
arestyrurj-207	81	25	way	way	NOUN
arestyrurj-207	81	26	.	.	PUNCT
arestyrurj-207	82	1	for	for	ADP
arestyrurj-207	82	2	the	the	DET
arestyrurj-207	82	3	confluent	confluent	ADJ
arestyrurj-207	82	4	cells	cell	NOUN
arestyrurj-207	82	5	,	,	PUNCT
arestyrurj-207	82	6	grem1	grem1	NOUN
arestyrurj-207	82	7	and	and	CCONJ
arestyrurj-207	82	8	wnt2b	wnt2b	PROPN
arestyrurj-207	82	9	tend	tend	VERB
arestyrurj-207	82	10	to	to	PART
arestyrurj-207	82	11	be	be	AUX
arestyrurj-207	82	12	downregulated	downregulate	VERB
arestyrurj-207	82	13	.	.	PUNCT
arestyrurj-207	83	1	grem1	grem1	PROPN
arestyrurj-207	83	2	is	be	AUX
arestyrurj-207	83	3	a	a	DET
arestyrurj-207	83	4	bmp	bmp	NOUN
arestyrurj-207	83	5	antagonist	antagonist	NOUN
arestyrurj-207	83	6	;	;	PUNCT
arestyrurj-207	83	7	therefore	therefore	ADV
arestyrurj-207	83	8	,	,	PUNCT
arestyrurj-207	83	9	by	by	ADP
arestyrurj-207	83	10	downregulating	downregulate	VERB
arestyrurj-207	83	11	the	the	DET
arestyrurj-207	83	12	gene	gene	NOUN
arestyrurj-207	83	13	bmp	bmp	NOUN
arestyrurj-207	83	14	can	can	AUX
arestyrurj-207	83	15	have	have	VERB
arestyrurj-207	83	16	a	a	DET
arestyrurj-207	83	17	larger	large	ADJ
arestyrurj-207	83	18	effect	effect	NOUN
arestyrurj-207	83	19	on	on	ADP
arestyrurj-207	83	20	the	the	DET
arestyrurj-207	83	21	epithelium	epithelium	NOUN
arestyrurj-207	83	22	which	which	PRON
arestyrurj-207	83	23	would	would	AUX
arestyrurj-207	83	24	lead	lead	VERB
arestyrurj-207	83	25	to	to	ADP
arestyrurj-207	83	26	a	a	DET
arestyrurj-207	83	27	decrease	decrease	NOUN
arestyrurj-207	83	28	in	in	ADP
arestyrurj-207	83	29	activity	activity	NOUN
arestyrurj-207	83	30	of	of	ADP
arestyrurj-207	83	31	the	the	DET
arestyrurj-207	83	32	wnt	wnt	PROPN
arestyrurj-207	83	33	/	/	SYM
arestyrurj-207	83	34	beta	beta	NOUN
arestyrurj-207	83	35	-	-	PUNCT
arestyrurj-207	83	36	catenin	catenin	NOUN
arestyrurj-207	83	37	pathway	pathway	NOUN
arestyrurj-207	83	38	.	.	PUNCT
arestyrurj-207	84	1	for	for	ADP
arestyrurj-207	84	2	the	the	DET
arestyrurj-207	84	3	sub	sub	ADJ
arestyrurj-207	84	4	-	-	ADJ
arestyrurj-207	84	5	confluent	confluent	ADJ
arestyrurj-207	84	6	mesenchyme	mesenchyme	NOUN
arestyrurj-207	84	7	cells	cell	NOUN
arestyrurj-207	84	8	,	,	PUNCT
arestyrurj-207	84	9	grem1	grem1	NOUN
arestyrurj-207	84	10	is	be	AUX
arestyrurj-207	84	11	downregulated	downregulate	VERB
arestyrurj-207	84	12	in	in	ADP
arestyrurj-207	84	13	all	all	DET
arestyrurj-207	84	14	experimental	experimental	ADJ
arestyrurj-207	84	15	groups	group	NOUN
arestyrurj-207	84	16	while	while	SCONJ
arestyrurj-207	84	17	wnt2b	wnt2b	PROPN
arestyrurj-207	84	18	is	be	AUX
arestyrurj-207	84	19	also	also	ADV
arestyrurj-207	84	20	downregulated	downregulate	VERB
arestyrurj-207	84	21	except	except	SCONJ
arestyrurj-207	84	22	in	in	ADP
arestyrurj-207	84	23	cells	cell	NOUN
arestyrurj-207	84	24	treated	treat	VERB
arestyrurj-207	84	25	with	with	ADP
arestyrurj-207	84	26	conditioned	condition	VERB
arestyrurj-207	84	27	ccm	ccm	NOUN
arestyrurj-207	84	28	from	from	ADP
arestyrurj-207	84	29	wild	wild	ADJ
arestyrurj-207	84	30	type	type	NOUN
arestyrurj-207	84	31	organoids	organoid	NOUN
arestyrurj-207	84	32	.	.	PUNCT
arestyrurj-207	85	1	again	again	ADV
arestyrurj-207	85	2	,	,	PUNCT
arestyrurj-207	85	3	the	the	DET
arestyrurj-207	85	4	conditioned	condition	VERB
arestyrurj-207	85	5	media	medium	NOUN
arestyrurj-207	85	6	from	from	ADP
arestyrurj-207	85	7	mutant	mutant	ADJ
arestyrurj-207	85	8	organoids	organoid	NOUN
arestyrurj-207	85	9	are	be	AUX
arestyrurj-207	85	10	causing	cause	VERB
arestyrurj-207	85	11	grem1	grem1	NOUN
arestyrurj-207	85	12	and	and	CCONJ
arestyrurj-207	85	13	wnt2b	wnt2b	PROPN
arestyrurj-207	85	14	to	to	PART
arestyrurj-207	85	15	be	be	AUX
arestyrurj-207	85	16	downregulated	downregulate	VERB
arestyrurj-207	85	17	in	in	ADP
arestyrurj-207	85	18	order	order	NOUN
arestyrurj-207	85	19	to	to	PART
arestyrurj-207	85	20	suppress	suppress	VERB
arestyrurj-207	85	21	mutant	mutant	ADJ
arestyrurj-207	85	22	epithelial	epithelial	ADJ
arestyrurj-207	85	23	growth	growth	NOUN
arestyrurj-207	85	24	.	.	PUNCT
arestyrurj-207	86	1	figure	figure	VERB
arestyrurj-207	86	2	1	1	NUM
arestyrurj-207	86	3	:	:	PUNCT
arestyrurj-207	86	4	h&e	h&e	PROPN
arestyrurj-207	86	5	staining	stain	VERB
arestyrurj-207	86	6	of	of	ADP
arestyrurj-207	86	7	two	two	NUM
arestyrurj-207	86	8	independent	independent	ADJ
arestyrurj-207	86	9	replicates	replicate	NOUN
arestyrurj-207	86	10	showing	show	VERB
arestyrurj-207	86	11	the	the	DET
arestyrurj-207	86	12	difference	difference	NOUN
arestyrurj-207	86	13	between	between	ADP
arestyrurj-207	86	14	the	the	DET
arestyrurj-207	86	15	control	control	NOUN
arestyrurj-207	86	16	and	and	CCONJ
arestyrurj-207	86	17	mutant	mutant	ADJ
arestyrurj-207	86	18	epithelium	epithelium	NOUN
arestyrurj-207	86	19	.	.	PUNCT
arestyrurj-207	87	1	figure	figure	NOUN
arestyrurj-207	87	2	2a	2a	NUM
arestyrurj-207	87	3	:	:	PUNCT
arestyrurj-207	87	4	the	the	DET
arestyrurj-207	87	5	image	image	NOUN
arestyrurj-207	87	6	shows	show	VERB
arestyrurj-207	87	7	the	the	DET
arestyrurj-207	87	8	density	density	NOUN
arestyrurj-207	87	9	of	of	ADP
arestyrurj-207	87	10	the	the	DET
arestyrurj-207	87	11	cells	cell	NOUN
arestyrurj-207	87	12	;	;	PUNCT
arestyrurj-207	87	13	cells	cell	NOUN
arestyrurj-207	87	14	are	be	AUX
arestyrurj-207	87	15	confluent	confluent	ADJ
arestyrurj-207	87	16	.	.	PUNCT
arestyrurj-207	88	1	647	647	NUM
arestyrurj-207	88	2	is	be	AUX
arestyrurj-207	88	3	the	the	DET
arestyrurj-207	88	4	confluent	confluent	ADJ
arestyrurj-207	88	5	mesenchyme	mesenchyme	NOUN
arestyrurj-207	88	6	cell	cell	NOUN
arestyrurj-207	88	7	line	line	NOUN
arestyrurj-207	88	8	.	.	PUNCT
arestyrurj-207	89	1	the	the	DET
arestyrurj-207	89	2	leftmost	leftmost	PROPN
arestyrurj-207	89	3	bars	bar	NOUN
arestyrurj-207	89	4	represent	represent	VERB
arestyrurj-207	89	5	grem1	grem1	NOUN
arestyrurj-207	89	6	and	and	CCONJ
arestyrurj-207	89	7	wnt2b	wnt2b	PROPN
arestyrurj-207	89	8	expression	expression	NOUN
arestyrurj-207	89	9	in	in	ADP
arestyrurj-207	89	10	the	the	DET
arestyrurj-207	89	11	control	control	NOUN
arestyrurj-207	89	12	:	:	PUNCT
arestyrurj-207	89	13	mesenchyme	mesenchyme	NOUN
arestyrurj-207	89	14	cells	cell	NOUN
arestyrurj-207	89	15	treated	treat	VERB
arestyrurj-207	89	16	with	with	ADP
arestyrurj-207	89	17	mesenchyme	mesenchyme	NOUN
arestyrurj-207	89	18	media	medium	NOUN
arestyrurj-207	89	19	.	.	PUNCT
arestyrurj-207	90	1	to	to	ADP
arestyrurj-207	90	2	the	the	DET
arestyrurj-207	90	3	right	right	NOUN
arestyrurj-207	90	4	of	of	ADP
arestyrurj-207	90	5	that	that	PRON
arestyrurj-207	90	6	is	be	AUX
arestyrurj-207	91	1	mesenchyme	mesenchyme	NOUN
arestyrurj-207	91	2	cells	cell	NOUN
arestyrurj-207	91	3	treated	treat	VERB
arestyrurj-207	91	4	with	with	ADP
arestyrurj-207	91	5	mesenchyme	mesenchyme	NOUN
arestyrurj-207	91	6	conditioned	condition	VERB
arestyrurj-207	91	7	media	medium	NOUN
arestyrurj-207	91	8	from	from	ADP
arestyrurj-207	91	9	mutant	mutant	ADJ
arestyrurj-207	91	10	organoids	organoid	NOUN
arestyrurj-207	91	11	(	(	PUNCT
arestyrurj-207	91	12	647	647	NUM
arestyrurj-207	91	13	mm	mm	NUM
arestyrurj-207	91	14	-	-	PUNCT
arestyrurj-207	91	15	cm	cm	NOUN
arestyrurj-207	91	16	exon3f	exon3f	PROPN
arestyrurj-207	91	17	/	/	SYM
arestyrurj-207	91	18	f	f	PROPN
arestyrurj-207	91	19	)	)	PUNCT
arestyrurj-207	91	20	.	.	PUNCT
arestyrurj-207	92	1	to	to	ADP
arestyrurj-207	92	2	the	the	DET
arestyrurj-207	92	3	right	right	NOUN
arestyrurj-207	92	4	of	of	ADP
arestyrurj-207	92	5	that	that	PRON
arestyrurj-207	92	6	is	be	AUX
arestyrurj-207	92	7	mesenchyme	mesenchyme	NOUN
arestyrurj-207	92	8	cells	cell	NOUN
arestyrurj-207	92	9	treated	treat	VERB
arestyrurj-207	92	10	with	with	ADP
arestyrurj-207	92	11	ccm	ccm	NOUN
arestyrurj-207	92	12	condition	condition	NOUN
arestyrurj-207	92	13	media	medium	NOUN
arestyrurj-207	92	14	from	from	ADP
arestyrurj-207	92	15	wild	wild	ADJ
arestyrurj-207	92	16	type	type	NOUN
arestyrurj-207	92	17	organoids	organoid	NOUN
arestyrurj-207	92	18	(	(	PUNCT
arestyrurj-207	92	19	647	647	NUM
arestyrurj-207	92	20	ccm	ccm	NOUN
arestyrurj-207	92	21	-	-	PUNCT
arestyrurj-207	92	22	cm	cm	NOUN
arestyrurj-207	92	23	wt	wt	NOUN
arestyrurj-207	92	24	)	)	PUNCT
arestyrurj-207	92	25	,	,	PUNCT
arestyrurj-207	92	26	and	and	CCONJ
arestyrurj-207	92	27	the	the	DET
arestyrurj-207	92	28	rightmost	rightmost	NOUN
arestyrurj-207	92	29	graph	graph	NOUN
arestyrurj-207	92	30	shows	show	VERB
arestyrurj-207	92	31	mesenchyme	mesenchyme	NOUN
arestyrurj-207	92	32	cells	cell	NOUN
arestyrurj-207	92	33	treated	treat	VERB
arestyrurj-207	92	34	with	with	ADP
arestyrurj-207	92	35	ccm	ccm	NOUN
arestyrurj-207	92	36	conditioned	condition	VERB
arestyrurj-207	92	37	media	medium	NOUN
arestyrurj-207	92	38	from	from	ADP
arestyrurj-207	92	39	mutant	mutant	ADJ
arestyrurj-207	92	40	organoids	organoid	NOUN
arestyrurj-207	92	41	(	(	PUNCT
arestyrurj-207	92	42	647	647	NUM
arestyrurj-207	92	43	ccm	ccm	NOUN
arestyrurj-207	92	44	-	-	PUNCT
arestyrurj-207	92	45	cm	cm	NOUN
arestyrurj-207	92	46	exon3f	exon3f	PROPN
arestyrurj-207	92	47	/	/	SYM
arestyrurj-207	92	48	f	f	PROPN
arestyrurj-207	92	49	)	)	PUNCT
arestyrurj-207	92	50	.	.	PUNCT
arestyrurj-207	93	1	the	the	DET
arestyrurj-207	93	2	graph	graph	NOUN
arestyrurj-207	93	3	shows	show	VERB
arestyrurj-207	93	4	relative	relative	ADJ
arestyrurj-207	93	5	gene	gene	NOUN
arestyrurj-207	93	6	expression	expression	NOUN
arestyrurj-207	93	7	(	(	PUNCT
arestyrurj-207	93	8	n=3	n=3	NOUN
arestyrurj-207	93	9	)	)	PUNCT
arestyrurj-207	93	10	,	,	PUNCT
arestyrurj-207	93	11	compared	compare	VERB
arestyrurj-207	93	12	to	to	ADP
arestyrurj-207	93	13	cells	cell	NOUN
arestyrurj-207	93	14	treated	treat	VERB
arestyrurj-207	93	15	with	with	ADP
arestyrurj-207	93	16	mesenchyme	mesenchyme	NOUN
arestyrurj-207	93	17	media	medium	NOUN
arestyrurj-207	93	18	.	.	PUNCT
arestyrurj-207	94	1	aresty	aresty	ADJ
arestyrurj-207	94	2	rutgers	rutgers	PROPN
arestyrurj-207	94	3	undergraduate	undergraduate	PROPN
arestyrurj-207	94	4	research	research	PROPN
arestyrurj-207	94	5	journal	journal	PROPN
arestyrurj-207	94	6	,	,	PUNCT
arestyrurj-207	94	7	volume	volume	NOUN
arestyrurj-207	94	8	i	i	PRON
arestyrurj-207	94	9	,	,	PUNCT
arestyrurj-207	94	10	issue	issue	NOUN
arestyrurj-207	94	11	iv	iv	NUM
arestyrurj-207	94	12	figure	figure	NOUN
arestyrurj-207	94	13	2b	2b	NOUN
arestyrurj-207	94	14	:	:	PUNCT
arestyrurj-207	94	15	image	image	NOUN
arestyrurj-207	94	16	shows	show	VERB
arestyrurj-207	94	17	the	the	DET
arestyrurj-207	94	18	density	density	NOUN
arestyrurj-207	94	19	of	of	ADP
arestyrurj-207	94	20	cells	cell	NOUN
arestyrurj-207	94	21	;	;	PUNCT
arestyrurj-207	94	22	cells	cell	NOUN
arestyrurj-207	94	23	are	be	AUX
arestyrurj-207	94	24	sub	sub	ADJ
arestyrurj-207	94	25	-	-	ADJ
arestyrurj-207	94	26	confluent	confluent	ADJ
arestyrurj-207	94	27	.	.	PUNCT
arestyrurj-207	95	1	graph	graph	NOUN
arestyrurj-207	95	2	shows	show	VERB
arestyrurj-207	95	3	relative	relative	ADJ
arestyrurj-207	95	4	gene	gene	NOUN
arestyrurj-207	95	5	expression	expression	NOUN
arestyrurj-207	95	6	of	of	ADP
arestyrurj-207	95	7	the	the	DET
arestyrurj-207	95	8	three	three	NUM
arestyrurj-207	95	9	samples	sample	NOUN
arestyrurj-207	95	10	treated	treat	VERB
arestyrurj-207	95	11	with	with	ADP
arestyrurj-207	95	12	conditioned	condition	VERB
arestyrurj-207	95	13	media	medium	NOUN
arestyrurj-207	95	14	to	to	ADP
arestyrurj-207	95	15	the	the	DET
arestyrurj-207	95	16	mesenchyme	mesenchyme	NOUN
arestyrurj-207	95	17	media	medium	NOUN
arestyrurj-207	95	18	for	for	ADP
arestyrurj-207	95	19	sub	sub	ADJ
arestyrurj-207	95	20	-	-	ADJ
arestyrurj-207	95	21	confluent	confluent	ADJ
arestyrurj-207	95	22	cells	cell	NOUN
arestyrurj-207	95	23	.	.	PUNCT
arestyrurj-207	96	1	graph	graph	NOUN
arestyrurj-207	96	2	portrays	portray	VERB
arestyrurj-207	96	3	same	same	ADJ
arestyrurj-207	96	4	conditions	condition	NOUN
arestyrurj-207	96	5	as	as	ADP
arestyrurj-207	96	6	graph	graph	NOUN
arestyrurj-207	96	7	above	above	ADV
arestyrurj-207	96	8	except	except	SCONJ
arestyrurj-207	96	9	for	for	ADP
arestyrurj-207	96	10	sub	sub	ADJ
arestyrurj-207	96	11	-	-	ADJ
arestyrurj-207	96	12	confluent	confluent	ADJ
arestyrurj-207	96	13	cells	cell	NOUN
arestyrurj-207	96	14	.	.	PUNCT
arestyrurj-207	97	1	the	the	DET
arestyrurj-207	97	2	graphs	graph	NOUN
arestyrurj-207	97	3	in	in	ADP
arestyrurj-207	97	4	figure	figure	NOUN
arestyrurj-207	97	5	3	3	NUM
arestyrurj-207	97	6	demonstrate	demonstrate	VERB
arestyrurj-207	97	7	the	the	DET
arestyrurj-207	97	8	relative	relative	ADJ
arestyrurj-207	97	9	gene	gene	NOUN
arestyrurj-207	97	10	expression	expression	NOUN
arestyrurj-207	97	11	seen	see	VERB
arestyrurj-207	97	12	across	across	ADP
arestyrurj-207	97	13	all	all	DET
arestyrurj-207	97	14	11	11	NUM
arestyrurj-207	97	15	protein	protein	NOUN
arestyrurj-207	97	16	coding	code	VERB
arestyrurj-207	97	17	genes	gene	NOUN
arestyrurj-207	97	18	that	that	PRON
arestyrurj-207	97	19	were	be	AUX
arestyrurj-207	97	20	tested	test	VERB
arestyrurj-207	97	21	.	.	PUNCT
arestyrurj-207	98	1	the	the	DET
arestyrurj-207	98	2	graph	graph	NOUN
arestyrurj-207	98	3	focuses	focus	VERB
arestyrurj-207	98	4	on	on	ADP
arestyrurj-207	98	5	the	the	DET
arestyrurj-207	98	6	mesenchyme	mesenchyme	NOUN
arestyrurj-207	98	7	conditioned	condition	VERB
arestyrurj-207	98	8	media	medium	NOUN
arestyrurj-207	98	9	from	from	ADP
arestyrurj-207	98	10	mutant	mutant	ADJ
arestyrurj-207	98	11	organoids	organoid	NOUN
arestyrurj-207	98	12	vs.	vs.	ADP
arestyrurj-207	98	13	the	the	DET
arestyrurj-207	98	14	control	control	NOUN
arestyrurj-207	98	15	.	.	PUNCT
arestyrurj-207	99	1	the	the	DET
arestyrurj-207	99	2	bmp	bmp	PROPN
arestyrurj-207	99	3	profile	profile	NOUN
arestyrurj-207	99	4	between	between	ADP
arestyrurj-207	99	5	the	the	DET
arestyrurj-207	99	6	confluent	confluent	ADJ
arestyrurj-207	99	7	and	and	CCONJ
arestyrurj-207	99	8	sub	sub	ADJ
arestyrurj-207	99	9	-	-	ADJ
arestyrurj-207	99	10	confluent	confluent	ADJ
arestyrurj-207	99	11	cells	cell	NOUN
arestyrurj-207	99	12	shows	show	VERB
arestyrurj-207	99	13	many	many	ADJ
arestyrurj-207	99	14	similarities	similarity	NOUN
arestyrurj-207	99	15	including	include	VERB
arestyrurj-207	99	16	bmp2	bmp2	ADJ
arestyrurj-207	99	17	and	and	CCONJ
arestyrurj-207	99	18	bmp3	bmp3	PROPN
arestyrurj-207	99	19	being	be	AUX
arestyrurj-207	99	20	downregulated	downregulate	VERB
arestyrurj-207	99	21	,	,	PUNCT
arestyrurj-207	99	22	bmp4	bmp4	NOUN
arestyrurj-207	99	23	staying	stay	VERB
arestyrurj-207	99	24	constant	constant	ADJ
arestyrurj-207	99	25	,	,	PUNCT
arestyrurj-207	99	26	and	and	CCONJ
arestyrurj-207	99	27	bmp6	bmp6	NOUN
arestyrurj-207	99	28	being	be	AUX
arestyrurj-207	99	29	upregulated	upregulate	VERB
arestyrurj-207	99	30	.	.	PUNCT
arestyrurj-207	100	1	the	the	DET
arestyrurj-207	100	2	upregulation	upregulation	NOUN
arestyrurj-207	100	3	in	in	ADP
arestyrurj-207	100	4	sub	sub	ADJ
arestyrurj-207	100	5	-	-	ADJ
arestyrurj-207	100	6	confluent	confluent	ADJ
arestyrurj-207	100	7	cells	cell	NOUN
arestyrurj-207	100	8	is	be	AUX
arestyrurj-207	100	9	much	much	ADV
arestyrurj-207	100	10	more	more	ADV
arestyrurj-207	100	11	profound	profound	ADJ
arestyrurj-207	100	12	.	.	PUNCT
arestyrurj-207	101	1	the	the	DET
arestyrurj-207	101	2	wnt	wnt	PROPN
arestyrurj-207	101	3	profile	profile	NOUN
arestyrurj-207	101	4	in	in	ADP
arestyrurj-207	101	5	confluent	confluent	ADJ
arestyrurj-207	101	6	and	and	CCONJ
arestyrurj-207	101	7	sub	sub	ADJ
arestyrurj-207	101	8	-	-	ADJ
arestyrurj-207	101	9	confluent	confluent	ADJ
arestyrurj-207	101	10	cells	cell	NOUN
arestyrurj-207	101	11	contain	contain	VERB
arestyrurj-207	101	12	some	some	DET
arestyrurj-207	101	13	differences	difference	NOUN
arestyrurj-207	101	14	like	like	ADP
arestyrurj-207	101	15	rspo3	rspo3	NOUN
arestyrurj-207	101	16	being	be	AUX
arestyrurj-207	101	17	upregulated	upregulate	VERB
arestyrurj-207	101	18	in	in	ADP
arestyrurj-207	101	19	confluent	confluent	ADJ
arestyrurj-207	101	20	cells	cell	NOUN
arestyrurj-207	101	21	while	while	SCONJ
arestyrurj-207	101	22	being	be	AUX
arestyrurj-207	101	23	downregulated	downregulate	VERB
arestyrurj-207	101	24	in	in	ADP
arestyrurj-207	101	25	sub	sub	ADJ
arestyrurj-207	101	26	-	-	ADJ
arestyrurj-207	101	27	confluent	confluent	ADJ
arestyrurj-207	101	28	cells	cell	NOUN
arestyrurj-207	101	29	.	.	PUNCT
arestyrurj-207	102	1	while	while	SCONJ
arestyrurj-207	102	2	wnt5a	wnt5a	PROPN
arestyrurj-207	102	3	is	be	AUX
arestyrurj-207	102	4	upregulated	upregulate	VERB
arestyrurj-207	102	5	in	in	ADP
arestyrurj-207	102	6	both	both	CCONJ
arestyrurj-207	102	7	confluent	confluent	ADJ
arestyrurj-207	102	8	and	and	CCONJ
arestyrurj-207	102	9	sub	sub	ADJ
arestyrurj-207	102	10	-	-	ADJ
arestyrurj-207	102	11	confluent	confluent	ADJ
arestyrurj-207	102	12	,	,	PUNCT
arestyrurj-207	102	13	wnt4	wnt4	PROPN
arestyrurj-207	102	14	is	be	AUX
arestyrurj-207	102	15	downregulated	downregulate	VERB
arestyrurj-207	102	16	in	in	ADP
arestyrurj-207	102	17	confluent	confluent	ADJ
arestyrurj-207	102	18	,	,	PUNCT
arestyrurj-207	102	19	while	while	SCONJ
arestyrurj-207	102	20	profoundly	profoundly	ADV
arestyrurj-207	102	21	upregulated	upregulate	VERB
arestyrurj-207	102	22	in	in	ADP
arestyrurj-207	102	23	sub	sub	ADJ
arestyrurj-207	102	24	-	-	ADJ
arestyrurj-207	102	25	confluent	confluent	ADJ
arestyrurj-207	102	26	cells	cell	NOUN
arestyrurj-207	102	27	.	.	PUNCT
arestyrurj-207	103	1	4	4	NUM
arestyrurj-207	103	2	discussion	discussion	NOUN
arestyrurj-207	103	3	the	the	DET
arestyrurj-207	103	4	goal	goal	NOUN
arestyrurj-207	103	5	of	of	ADP
arestyrurj-207	103	6	the	the	DET
arestyrurj-207	103	7	experiment	experiment	NOUN
arestyrurj-207	103	8	is	be	AUX
arestyrurj-207	103	9	to	to	PART
arestyrurj-207	103	10	identify	identify	VERB
arestyrurj-207	103	11	possible	possible	ADJ
arestyrurj-207	103	12	signaling	signal	VERB
arestyrurj-207	103	13	pathways	pathway	NOUN
arestyrurj-207	103	14	that	that	SCONJ
arestyrurj-207	103	15	mesenchymal	mesenchymal	NOUN
arestyrurj-207	103	16	cells	cell	NOUN
arestyrurj-207	103	17	could	could	AUX
arestyrurj-207	103	18	use	use	VERB
arestyrurj-207	103	19	to	to	PART
arestyrurj-207	103	20	communicate	communicate	VERB
arestyrurj-207	103	21	with	with	ADP
arestyrurj-207	103	22	epithelial	epithelial	ADJ
arestyrurj-207	103	23	cells	cell	NOUN
arestyrurj-207	103	24	.	.	PUNCT
arestyrurj-207	104	1	while	while	SCONJ
arestyrurj-207	104	2	the	the	DET
arestyrurj-207	104	3	multitude	multitude	NOUN
arestyrurj-207	104	4	of	of	ADP
arestyrurj-207	104	5	cells	cell	NOUN
arestyrurj-207	104	6	in	in	ADP
arestyrurj-207	104	7	the	the	DET
arestyrurj-207	104	8	small	small	ADJ
arestyrurj-207	104	9	intestine	intestine	NOUN
arestyrurj-207	104	10	and	and	CCONJ
arestyrurj-207	104	11	their	their	PRON
arestyrurj-207	104	12	functions	function	NOUN
arestyrurj-207	104	13	are	be	AUX
arestyrurj-207	104	14	known	know	VERB
arestyrurj-207	104	15	,	,	PUNCT
arestyrurj-207	104	16	like	like	ADP
arestyrurj-207	104	17	trophocytes	trophocyte	NOUN
arestyrurj-207	104	18	,	,	PUNCT
arestyrurj-207	104	19	telocytes	telocyte	NOUN
arestyrurj-207	104	20	,	,	PUNCT
arestyrurj-207	104	21	and	and	CCONJ
arestyrurj-207	104	22	enterocytes	enterocyte	NOUN
arestyrurj-207	104	23	(	(	PUNCT
arestyrurj-207	104	24	mccarthy	mccarthy	PROPN
arestyrurj-207	104	25	et	et	PROPN
arestyrurj-207	104	26	al	al	PROPN
arestyrurj-207	104	27	.	.	PROPN
arestyrurj-207	104	28	,	,	PUNCT
arestyrurj-207	104	29	2020	2020	NUM
arestyrurj-207	104	30	)	)	PUNCT
arestyrurj-207	104	31	,	,	PUNCT
arestyrurj-207	104	32	their	their	PRON
arestyrurj-207	104	33	ability	ability	NOUN
arestyrurj-207	104	34	to	to	PART
arestyrurj-207	104	35	communicate	communicate	VERB
arestyrurj-207	104	36	with	with	ADP
arestyrurj-207	104	37	the	the	DET
arestyrurj-207	104	38	microenvironment	microenvironment	NOUN
arestyrurj-207	104	39	is	be	AUX
arestyrurj-207	104	40	understudied	understudied	ADJ
arestyrurj-207	104	41	.	.	PUNCT
arestyrurj-207	105	1	the	the	DET
arestyrurj-207	105	2	signaling	signal	VERB
arestyrurj-207	105	3	crosstalk	crosstalk	NOUN
arestyrurj-207	105	4	between	between	ADP
arestyrurj-207	105	5	the	the	DET
arestyrurj-207	105	6	stroma	stroma	ADJ
arestyrurj-207	105	7	cell	cell	NOUN
arestyrurj-207	105	8	population	population	NOUN
arestyrurj-207	105	9	and	and	CCONJ
arestyrurj-207	105	10	the	the	DET
arestyrurj-207	105	11	epithelium	epithelium	NOUN
arestyrurj-207	105	12	remains	remain	VERB
arestyrurj-207	105	13	unknown	unknown	ADJ
arestyrurj-207	105	14	.	.	PUNCT
arestyrurj-207	106	1	understanding	understand	VERB
arestyrurj-207	106	2	how	how	SCONJ
arestyrurj-207	106	3	these	these	DET
arestyrurj-207	106	4	two	two	NUM
arestyrurj-207	106	5	types	type	NOUN
arestyrurj-207	106	6	of	of	ADP
arestyrurj-207	106	7	cells	cell	NOUN
arestyrurj-207	106	8	may	may	AUX
arestyrurj-207	106	9	communicate	communicate	VERB
arestyrurj-207	106	10	can	can	AUX
arestyrurj-207	106	11	provide	provide	VERB
arestyrurj-207	106	12	novel	novel	ADJ
arestyrurj-207	106	13	therapeutic	therapeutic	ADJ
arestyrurj-207	106	14	interventions	intervention	NOUN
arestyrurj-207	106	15	during	during	ADP
arestyrurj-207	106	16	initial	initial	ADJ
arestyrurj-207	106	17	tumor	tumor	NOUN
arestyrurj-207	106	18	development	development	NOUN
arestyrurj-207	106	19	.	.	PUNCT
arestyrurj-207	107	1	histological	histological	ADJ
arestyrurj-207	107	2	review	review	NOUN
arestyrurj-207	107	3	of	of	ADP
arestyrurj-207	107	4	h&e	h&e	PROPN
arestyrurj-207	107	5	stained	stain	VERB
arestyrurj-207	107	6	slides	slide	NOUN
arestyrurj-207	107	7	reported	report	VERB
arestyrurj-207	107	8	a	a	DET
arestyrurj-207	107	9	lack	lack	NOUN
arestyrurj-207	107	10	of	of	ADP
arestyrurj-207	107	11	altered	altered	ADJ
arestyrurj-207	107	12	or	or	CCONJ
arestyrurj-207	107	13	abnormal	abnormal	ADJ
arestyrurj-207	107	14	tissue	tissue	NOUN
arestyrurj-207	107	15	structures	structure	NOUN
arestyrurj-207	107	16	,	,	PUNCT
arestyrurj-207	107	17	suggesting	suggest	VERB
arestyrurj-207	107	18	that	that	SCONJ
arestyrurj-207	107	19	the	the	DET
arestyrurj-207	107	20	mesenchyme	mesenchyme	NOUN
arestyrurj-207	107	21	is	be	AUX
arestyrurj-207	107	22	responsible	responsible	ADJ
arestyrurj-207	107	23	for	for	ADP
arestyrurj-207	107	24	suppressing	suppress	VERB
arestyrurj-207	107	25	mutant	mutant	ADJ
arestyrurj-207	107	26	epithelial	epithelial	ADJ
arestyrurj-207	107	27	growth	growth	NOUN
arestyrurj-207	107	28	.	.	PUNCT
arestyrurj-207	108	1	protein	protein	NOUN
arestyrurj-207	108	2	expressing	express	VERB
arestyrurj-207	108	3	genes	gene	NOUN
arestyrurj-207	108	4	such	such	ADJ
arestyrurj-207	108	5	as	as	ADP
arestyrurj-207	108	6	wnt2b	wnt2b	PROPN
arestyrurj-207	108	7	,	,	PUNCT
arestyrurj-207	108	8	grem1	grem1	NOUN
arestyrurj-207	108	9	,	,	PUNCT
arestyrurj-207	108	10	and	and	CCONJ
arestyrurj-207	108	11	bmp6	bmp6	NOUN
arestyrurj-207	108	12	may	may	AUX
arestyrurj-207	108	13	be	be	AUX
arestyrurj-207	108	14	responsible	responsible	ADJ
arestyrurj-207	108	15	for	for	ADP
arestyrurj-207	108	16	the	the	DET
arestyrurj-207	108	17	cross	cross	NOUN
arestyrurj-207	108	18	talk	talk	NOUN
arestyrurj-207	108	19	between	between	ADP
arestyrurj-207	108	20	these	these	DET
arestyrurj-207	108	21	two	two	NUM
arestyrurj-207	108	22	cell	cell	NOUN
arestyrurj-207	108	23	types	type	NOUN
arestyrurj-207	108	24	.	.	PUNCT
arestyrurj-207	109	1	when	when	SCONJ
arestyrurj-207	109	2	conditioned	condition	VERB
arestyrurj-207	109	3	media	medium	NOUN
arestyrurj-207	109	4	from	from	ADP
arestyrurj-207	109	5	mutant	mutant	ADJ
arestyrurj-207	109	6	organoids	organoid	NOUN
arestyrurj-207	109	7	is	be	AUX
arestyrurj-207	109	8	introduced	introduce	VERB
arestyrurj-207	109	9	to	to	PART
arestyrurj-207	109	10	mesenchyme	mesenchyme	VERB
arestyrurj-207	109	11	cells	cell	NOUN
arestyrurj-207	109	12	grem1	grem1	NOUN
arestyrurj-207	109	13	and	and	CCONJ
arestyrurj-207	109	14	wnt2b	wnt2b	PROPN
arestyrurj-207	109	15	are	be	AUX
arestyrurj-207	109	16	downregulated	downregulate	VERB
arestyrurj-207	109	17	.	.	PUNCT
arestyrurj-207	110	1	the	the	DET
arestyrurj-207	110	2	downregulation	downregulation	NOUN
arestyrurj-207	110	3	of	of	ADP
arestyrurj-207	110	4	wnt	wnt	PROPN
arestyrurj-207	110	5	prevents	prevent	VERB
arestyrurj-207	110	6	the	the	DET
arestyrurj-207	110	7	expression	expression	NOUN
arestyrurj-207	110	8	of	of	ADP
arestyrurj-207	110	9	wnt	wnt	PROPN
arestyrurj-207	110	10	target	target	NOUN
arestyrurj-207	110	11	genes	gene	NOUN
arestyrurj-207	110	12	,	,	PUNCT
arestyrurj-207	110	13	therefore	therefore	ADV
arestyrurj-207	110	14	controlling	control	VERB
arestyrurj-207	110	15	mutant	mutant	ADJ
arestyrurj-207	110	16	transformation	transformation	NOUN
arestyrurj-207	110	17	.	.	PUNCT
arestyrurj-207	111	1	grem1	grem1	NOUN
arestyrurj-207	112	1	in	in	ADP
arestyrurj-207	112	2	these	these	DET
arestyrurj-207	112	3	cell	cell	NOUN
arestyrurj-207	112	4	lines	line	NOUN
arestyrurj-207	112	5	is	be	AUX
arestyrurj-207	112	6	seen	see	VERB
arestyrurj-207	112	7	to	to	PART
arestyrurj-207	112	8	be	be	AUX
arestyrurj-207	112	9	downregulated	downregulate	VERB
arestyrurj-207	112	10	,	,	PUNCT
arestyrurj-207	112	11	which	which	PRON
arestyrurj-207	112	12	directly	directly	ADV
arestyrurj-207	112	13	and	and	CCONJ
arestyrurj-207	112	14	indirectly	indirectly	ADV
arestyrurj-207	112	15	(	(	PUNCT
arestyrurj-207	112	16	by	by	ADP
arestyrurj-207	112	17	inhibiting	inhibit	VERB
arestyrurj-207	112	18	bmp	bmp	NOUN
arestyrurj-207	112	19	genes	gene	NOUN
arestyrurj-207	112	20	)	)	PUNCT
arestyrurj-207	112	21	prevents	prevent	VERB
arestyrurj-207	112	22	epithelial	epithelial	ADJ
arestyrurj-207	112	23	transformation	transformation	NOUN
arestyrurj-207	112	24	.	.	PUNCT
arestyrurj-207	113	1	what	what	PRON
arestyrurj-207	113	2	is	be	AUX
arestyrurj-207	113	3	unusual	unusual	ADJ
arestyrurj-207	113	4	is	be	AUX
arestyrurj-207	113	5	why	why	SCONJ
arestyrurj-207	113	6	most	most	ADJ
arestyrurj-207	113	7	of	of	ADP
arestyrurj-207	113	8	the	the	DET
arestyrurj-207	113	9	bmp	bmp	PROPN
arestyrurj-207	113	10	genes	gene	NOUN
arestyrurj-207	113	11	are	be	AUX
arestyrurj-207	113	12	either	either	CCONJ
arestyrurj-207	113	13	downregulated	downregulate	VERB
arestyrurj-207	113	14	or	or	CCONJ
arestyrurj-207	113	15	stay	stay	VERB
arestyrurj-207	113	16	constant	constant	ADJ
arestyrurj-207	113	17	while	while	SCONJ
arestyrurj-207	113	18	bmp6	bmp6	NOUN
arestyrurj-207	113	19	is	be	AUX
arestyrurj-207	113	20	upregulated	upregulate	VERB
arestyrurj-207	113	21	.	.	PUNCT
arestyrurj-207	114	1	bmp	bmp	NOUN
arestyrurj-207	114	2	signaling	signaling	NOUN
arestyrurj-207	114	3	can	can	AUX
arestyrurj-207	114	4	be	be	AUX
arestyrurj-207	114	5	seen	see	VERB
arestyrurj-207	114	6	as	as	ADP
arestyrurj-207	114	7	the	the	DET
arestyrurj-207	114	8	primary	primary	ADJ
arestyrurj-207	114	9	suppressor	suppressor	NOUN
arestyrurj-207	114	10	of	of	ADP
arestyrurj-207	114	11	dedifferentiation	dedifferentiation	NOUN
arestyrurj-207	114	12	in	in	ADP
arestyrurj-207	114	13	the	the	DET
arestyrurj-207	114	14	intestinal	intestinal	ADJ
arestyrurj-207	114	15	epithelium	epithelium	NOUN
arestyrurj-207	114	16	,	,	PUNCT
arestyrurj-207	114	17	and	and	CCONJ
arestyrurj-207	114	18	better	well	ADJ
arestyrurj-207	114	19	understanding	understanding	NOUN
arestyrurj-207	114	20	of	of	ADP
arestyrurj-207	114	21	its	its	PRON
arestyrurj-207	114	22	ligands	ligand	NOUN
arestyrurj-207	114	23	will	will	AUX
arestyrurj-207	114	24	provide	provide	VERB
arestyrurj-207	114	25	important	important	ADJ
arestyrurj-207	114	26	steps	step	NOUN
arestyrurj-207	114	27	to	to	ADP
arestyrurj-207	114	28	how	how	SCONJ
arestyrurj-207	114	29	the	the	DET
arestyrurj-207	114	30	epithelium	epithelium	NOUN
arestyrurj-207	114	31	protects	protect	VERB
arestyrurj-207	114	32	against	against	ADP
arestyrurj-207	114	33	oncogenesis	oncogenesis	NOUN
arestyrurj-207	114	34	(	(	PUNCT
arestyrurj-207	114	35	perekatt	perekatt	NOUN
arestyrurj-207	114	36	et	et	NOUN
arestyrurj-207	114	37	al	al	PROPN
arestyrurj-207	114	38	.	.	PROPN
arestyrurj-207	114	39	,	,	PUNCT
arestyrurj-207	114	40	2018	2018	NUM
arestyrurj-207	114	41	)	)	PUNCT
arestyrurj-207	114	42	.	.	PUNCT
arestyrurj-207	115	1	although	although	SCONJ
arestyrurj-207	115	2	the	the	DET
arestyrurj-207	115	3	bmp	bmp	NOUN
arestyrurj-207	115	4	gene	gene	NOUN
arestyrurj-207	115	5	expression	expression	NOUN
arestyrurj-207	115	6	is	be	AUX
arestyrurj-207	115	7	found	find	VERB
arestyrurj-207	115	8	to	to	ADP
arestyrurj-207	115	9	aresty	aresty	ADJ
arestyrurj-207	115	10	rutgers	rutgers	PROPN
arestyrurj-207	115	11	undergraduate	undergraduate	PROPN
arestyrurj-207	115	12	research	research	PROPN
arestyrurj-207	115	13	journal	journal	PROPN
arestyrurj-207	115	14	,	,	PUNCT
arestyrurj-207	115	15	volume	volume	NOUN
arestyrurj-207	115	16	i	i	PRON
arestyrurj-207	115	17	,	,	PUNCT
arestyrurj-207	115	18	issue	issue	NOUN
arestyrurj-207	115	19	iv	iv	NUM
arestyrurj-207	115	20	figure	figure	NOUN
arestyrurj-207	115	21	3	3	NUM
arestyrurj-207	115	22	:	:	PUNCT
arestyrurj-207	115	23	graphs	graph	NOUN
arestyrurj-207	115	24	show	show	VERB
arestyrurj-207	115	25	relative	relative	ADJ
arestyrurj-207	115	26	gene	gene	NOUN
arestyrurj-207	115	27	expression	expression	NOUN
arestyrurj-207	115	28	of	of	ADP
arestyrurj-207	115	29	the	the	DET
arestyrurj-207	115	30	aforementioned	aforementioned	ADJ
arestyrurj-207	115	31	11	11	NUM
arestyrurj-207	115	32	genes	gene	NOUN
arestyrurj-207	115	33	in	in	ADP
arestyrurj-207	115	34	sub	sub	ADJ
arestyrurj-207	115	35	-	-	ADJ
arestyrurj-207	115	36	confluent	confluent	ADJ
arestyrurj-207	115	37	and	and	CCONJ
arestyrurj-207	115	38	confluent	confluent	ADJ
arestyrurj-207	115	39	mesenchyme	mesenchyme	NOUN
arestyrurj-207	115	40	cells	cell	NOUN
arestyrurj-207	115	41	.	.	PUNCT
arestyrurj-207	116	1	graph	graph	NOUN
arestyrurj-207	116	2	compares	compare	VERB
arestyrurj-207	116	3	the	the	DET
arestyrurj-207	116	4	major	major	ADJ
arestyrurj-207	116	5	experimental	experimental	ADJ
arestyrurj-207	116	6	group	group	NOUN
arestyrurj-207	116	7	to	to	ADP
arestyrurj-207	116	8	the	the	DET
arestyrurj-207	116	9	control	control	NOUN
arestyrurj-207	116	10	group	group	NOUN
arestyrurj-207	116	11	.	.	PUNCT
arestyrurj-207	117	1	because	because	SCONJ
arestyrurj-207	117	2	ccm	ccm	PROPN
arestyrurj-207	117	3	is	be	AUX
arestyrurj-207	117	4	the	the	DET
arestyrurj-207	117	5	primary	primary	ADJ
arestyrurj-207	117	6	media	medium	NOUN
arestyrurj-207	117	7	used	use	VERB
arestyrurj-207	117	8	to	to	PART
arestyrurj-207	117	9	grow	grow	VERB
arestyrurj-207	117	10	and	and	CCONJ
arestyrurj-207	117	11	sustain	sustain	VERB
arestyrurj-207	117	12	organoids	organoid	NOUN
arestyrurj-207	117	13	,	,	PUNCT
arestyrurj-207	117	14	its	its	PRON
arestyrurj-207	117	15	data	datum	NOUN
arestyrurj-207	117	16	would	would	AUX
arestyrurj-207	117	17	be	be	AUX
arestyrurj-207	117	18	most	most	ADV
arestyrurj-207	117	19	resembled	resemble	VERB
arestyrurj-207	117	20	in	in	ADP
arestyrurj-207	117	21	-	-	PUNCT
arestyrurj-207	117	22	vivo	vivo	NOUN
arestyrurj-207	117	23	conditions	condition	NOUN
arestyrurj-207	117	24	.	.	PUNCT
arestyrurj-207	118	1	this	this	DET
arestyrurj-207	118	2	group	group	NOUN
arestyrurj-207	118	3	would	would	AUX
arestyrurj-207	118	4	have	have	VERB
arestyrurj-207	118	5	organoids	organoid	NOUN
arestyrurj-207	118	6	function	function	VERB
arestyrurj-207	118	7	normally	normally	ADV
arestyrurj-207	118	8	so	so	SCONJ
arestyrurj-207	118	9	that	that	SCONJ
arestyrurj-207	118	10	the	the	DET
arestyrurj-207	118	11	conditioned	condition	VERB
arestyrurj-207	118	12	media	medium	NOUN
arestyrurj-207	118	13	would	would	AUX
arestyrurj-207	118	14	mimic	mimic	VERB
arestyrurj-207	118	15	in	in	ADP
arestyrurj-207	118	16	-	-	PUNCT
arestyrurj-207	118	17	vivo	vivo	NOUN
arestyrurj-207	118	18	conditions	condition	NOUN
arestyrurj-207	118	19	,	,	PUNCT
arestyrurj-207	118	20	and	and	CCONJ
arestyrurj-207	118	21	then	then	ADV
arestyrurj-207	118	22	the	the	DET
arestyrurj-207	118	23	mesenchyme	mesenchyme	NOUN
arestyrurj-207	118	24	response	response	NOUN
arestyrurj-207	118	25	could	could	AUX
arestyrurj-207	118	26	be	be	AUX
arestyrurj-207	118	27	observed	observe	VERB
arestyrurj-207	118	28	.	.	PUNCT
arestyrurj-207	119	1	not	not	PART
arestyrurj-207	119	2	increase	increase	VERB
arestyrurj-207	119	3	,	,	PUNCT
arestyrurj-207	119	4	this	this	PRON
arestyrurj-207	119	5	could	could	AUX
arestyrurj-207	119	6	be	be	AUX
arestyrurj-207	119	7	because	because	SCONJ
arestyrurj-207	119	8	grem1	grem1	NOUN
arestyrurj-207	119	9	expression	expression	NOUN
arestyrurj-207	119	10	is	be	AUX
arestyrurj-207	119	11	downregulated	downregulate	VERB
arestyrurj-207	119	12	,	,	PUNCT
arestyrurj-207	119	13	leading	lead	VERB
arestyrurj-207	119	14	to	to	ADP
arestyrurj-207	119	15	the	the	DET
arestyrurj-207	119	16	translation	translation	NOUN
arestyrurj-207	119	17	of	of	ADP
arestyrurj-207	119	18	more	more	ADJ
arestyrurj-207	119	19	bmp	bmp	ADJ
arestyrurj-207	119	20	proteins	protein	NOUN
arestyrurj-207	119	21	.	.	PUNCT
arestyrurj-207	120	1	the	the	DET
arestyrurj-207	120	2	up	up	ADJ
arestyrurj-207	120	3	and	and	CCONJ
arestyrurj-207	120	4	down	down	ADP
arestyrurj-207	120	5	regulation	regulation	NOUN
arestyrurj-207	120	6	of	of	ADP
arestyrurj-207	120	7	bmp	bmp	NOUN
arestyrurj-207	120	8	,	,	PUNCT
arestyrurj-207	120	9	grem1	grem1	NOUN
arestyrurj-207	120	10	,	,	PUNCT
arestyrurj-207	120	11	and	and	CCONJ
arestyrurj-207	120	12	wnt2b	wnt2b	PROPN
arestyrurj-207	120	13	ligands	ligand	NOUN
arestyrurj-207	120	14	may	may	AUX
arestyrurj-207	120	15	be	be	AUX
arestyrurj-207	120	16	,	,	PUNCT
arestyrurj-207	120	17	in	in	ADP
arestyrurj-207	120	18	part	part	NOUN
arestyrurj-207	120	19	,	,	PUNCT
arestyrurj-207	120	20	how	how	SCONJ
arestyrurj-207	120	21	the	the	DET
arestyrurj-207	120	22	mesenchyme	mesenchyme	NOUN
arestyrurj-207	120	23	is	be	AUX
arestyrurj-207	120	24	influencing	influence	VERB
arestyrurj-207	120	25	epithelial	epithelial	ADJ
arestyrurj-207	120	26	cells	cell	NOUN
arestyrurj-207	120	27	,	,	PUNCT
arestyrurj-207	120	28	preventing	prevent	VERB
arestyrurj-207	120	29	early	early	ADJ
arestyrurj-207	120	30	tumorigenesis	tumorigenesis	NOUN
arestyrurj-207	120	31	.	.	PUNCT
arestyrurj-207	121	1	the	the	DET
arestyrurj-207	121	2	experiment	experiment	NOUN
arestyrurj-207	121	3	demonstrated	demonstrate	VERB
arestyrurj-207	121	4	the	the	DET
arestyrurj-207	121	5	differences	difference	NOUN
arestyrurj-207	121	6	between	between	ADP
arestyrurj-207	121	7	confluent	confluent	ADJ
arestyrurj-207	121	8	and	and	CCONJ
arestyrurj-207	121	9	sub	sub	ADJ
arestyrurj-207	121	10	-	-	ADJ
arestyrurj-207	121	11	confluent	confluent	ADJ
arestyrurj-207	121	12	mesenchyme	mesenchyme	NOUN
arestyrurj-207	121	13	cells	cell	NOUN
arestyrurj-207	121	14	,	,	PUNCT
arestyrurj-207	121	15	as	as	ADV
arestyrurj-207	121	16	well	well	ADV
arestyrurj-207	121	17	as	as	ADP
arestyrurj-207	121	18	how	how	SCONJ
arestyrurj-207	121	19	different	different	ADJ
arestyrurj-207	121	20	conditioned	conditioned	ADJ
arestyrurj-207	121	21	media	medium	NOUN
arestyrurj-207	121	22	affects	affect	VERB
arestyrurj-207	121	23	mesenchyme	mesenchyme	NOUN
arestyrurj-207	121	24	cells	cell	NOUN
arestyrurj-207	121	25	.	.	PUNCT
arestyrurj-207	122	1	these	these	DET
arestyrurj-207	122	2	differences	difference	NOUN
arestyrurj-207	122	3	are	be	AUX
arestyrurj-207	122	4	most	most	ADV
arestyrurj-207	122	5	profoundly	profoundly	ADV
arestyrurj-207	122	6	seen	see	VERB
arestyrurj-207	122	7	in	in	ADP
arestyrurj-207	122	8	the	the	DET
arestyrurj-207	122	9	genes	gene	NOUN
arestyrurj-207	122	10	bmp6	bmp6	NOUN
arestyrurj-207	122	11	and	and	CCONJ
arestyrurj-207	122	12	wnt4	wnt4	PROPN
arestyrurj-207	122	13	.	.	PUNCT
arestyrurj-207	123	1	confluent	confluent	ADJ
arestyrurj-207	123	2	cells	cell	NOUN
arestyrurj-207	123	3	have	have	VERB
arestyrurj-207	123	4	the	the	DET
arestyrurj-207	123	5	ability	ability	NOUN
arestyrurj-207	123	6	to	to	PART
arestyrurj-207	123	7	sense	sense	VERB
arestyrurj-207	123	8	when	when	SCONJ
arestyrurj-207	123	9	they	they	PRON
arestyrurj-207	123	10	are	be	AUX
arestyrurj-207	123	11	running	run	VERB
arestyrurj-207	123	12	out	out	ADP
arestyrurj-207	123	13	of	of	ADP
arestyrurj-207	123	14	space	space	NOUN
arestyrurj-207	123	15	,	,	PUNCT
arestyrurj-207	123	16	which	which	PRON
arestyrurj-207	123	17	can	can	AUX
arestyrurj-207	123	18	cause	cause	VERB
arestyrurj-207	123	19	the	the	DET
arestyrurj-207	123	20	cells	cell	NOUN
arestyrurj-207	123	21	to	to	PART
arestyrurj-207	123	22	become	become	VERB
arestyrurj-207	123	23	less	less	ADV
arestyrurj-207	123	24	proliferative	proliferative	ADJ
arestyrurj-207	123	25	.	.	PUNCT
arestyrurj-207	124	1	sub	sub	ADJ
arestyrurj-207	124	2	-	-	ADJ
arestyrurj-207	124	3	confluent	confluent	ADJ
arestyrurj-207	124	4	cells	cell	NOUN
arestyrurj-207	124	5	are	be	AUX
arestyrurj-207	124	6	rather	rather	ADV
arestyrurj-207	124	7	in	in	ADP
arestyrurj-207	124	8	a	a	DET
arestyrurj-207	124	9	more	more	ADV
arestyrurj-207	124	10	active	active	ADJ
arestyrurj-207	124	11	growth	growth	NOUN
arestyrurj-207	124	12	phase	phase	NOUN
arestyrurj-207	124	13	.	.	PUNCT
arestyrurj-207	125	1	this	this	PRON
arestyrurj-207	125	2	could	could	AUX
arestyrurj-207	125	3	be	be	AUX
arestyrurj-207	125	4	affecting	affect	VERB
arestyrurj-207	125	5	the	the	DET
arestyrurj-207	125	6	signals	signal	NOUN
arestyrurj-207	125	7	the	the	DET
arestyrurj-207	125	8	mesenchyme	mesenchyme	NOUN
arestyrurj-207	125	9	releases	release	NOUN
arestyrurj-207	125	10	to	to	ADP
arestyrurj-207	125	11	the	the	DET
arestyrurj-207	125	12	aresty	aresty	ADJ
arestyrurj-207	125	13	rutgers	rutgers	PROPN
arestyrurj-207	125	14	undergraduate	undergraduate	PROPN
arestyrurj-207	125	15	research	research	PROPN
arestyrurj-207	125	16	journal	journal	PROPN
arestyrurj-207	125	17	,	,	PUNCT
arestyrurj-207	125	18	volume	volume	NOUN
arestyrurj-207	125	19	i	i	PRON
arestyrurj-207	125	20	,	,	PUNCT
arestyrurj-207	125	21	issue	issue	NOUN
arestyrurj-207	125	22	iv	iv	NUM
arestyrurj-207	125	23	epithelium	epithelium	NOUN
arestyrurj-207	125	24	,	,	PUNCT
arestyrurj-207	125	25	and	and	CCONJ
arestyrurj-207	125	26	responsible	responsible	ADJ
arestyrurj-207	125	27	for	for	ADP
arestyrurj-207	125	28	the	the	DET
arestyrurj-207	125	29	difference	difference	NOUN
arestyrurj-207	125	30	seen	see	VERB
arestyrurj-207	125	31	in	in	ADP
arestyrurj-207	125	32	response	response	NOUN
arestyrurj-207	125	33	between	between	ADP
arestyrurj-207	125	34	confluent	confluent	ADJ
arestyrurj-207	125	35	and	and	CCONJ
arestyrurj-207	125	36	subconfluent	subconfluent	ADJ
arestyrurj-207	125	37	cells	cell	NOUN
arestyrurj-207	125	38	.	.	PUNCT
arestyrurj-207	126	1	these	these	DET
arestyrurj-207	126	2	results	result	NOUN
arestyrurj-207	126	3	come	come	VERB
arestyrurj-207	126	4	from	from	ADP
arestyrurj-207	126	5	a	a	DET
arestyrurj-207	126	6	single	single	ADJ
arestyrurj-207	126	7	experimental	experimental	ADJ
arestyrurj-207	126	8	design	design	NOUN
arestyrurj-207	126	9	and	and	CCONJ
arestyrurj-207	126	10	provide	provide	VERB
arestyrurj-207	126	11	a	a	DET
arestyrurj-207	126	12	basis	basis	NOUN
arestyrurj-207	126	13	for	for	ADP
arestyrurj-207	126	14	future	future	ADJ
arestyrurj-207	126	15	experiments	experiment	NOUN
arestyrurj-207	126	16	.	.	PUNCT
arestyrurj-207	127	1	bmp	bmp	PROPN
arestyrurj-207	127	2	,	,	PUNCT
arestyrurj-207	127	3	grem1	grem1	PROPN
arestyrurj-207	127	4	,	,	PUNCT
arestyrurj-207	127	5	and	and	CCONJ
arestyrurj-207	127	6	wnt2b	wnt2b	PROPN
arestyrurj-207	127	7	may	may	AUX
arestyrurj-207	127	8	be	be	AUX
arestyrurj-207	127	9	signals	signal	NOUN
arestyrurj-207	127	10	that	that	PRON
arestyrurj-207	127	11	allow	allow	VERB
arestyrurj-207	127	12	the	the	DET
arestyrurj-207	127	13	mesenchyme	mesenchyme	NOUN
arestyrurj-207	127	14	to	to	PART
arestyrurj-207	127	15	communicate	communicate	VERB
arestyrurj-207	127	16	with	with	ADP
arestyrurj-207	127	17	the	the	DET
arestyrurj-207	127	18	transformed	transform	VERB
arestyrurj-207	127	19	epithelium	epithelium	NOUN
arestyrurj-207	127	20	.	.	PUNCT
arestyrurj-207	128	1	these	these	DET
arestyrurj-207	128	2	genes	gene	NOUN
arestyrurj-207	128	3	could	could	AUX
arestyrurj-207	128	4	be	be	AUX
arestyrurj-207	128	5	responsible	responsible	ADJ
arestyrurj-207	128	6	for	for	ADP
arestyrurj-207	128	7	early	early	ADJ
arestyrurj-207	128	8	prevention	prevention	NOUN
arestyrurj-207	128	9	of	of	ADP
arestyrurj-207	128	10	initial	initial	ADJ
arestyrurj-207	128	11	tumorigenesis	tumorigenesis	NOUN
arestyrurj-207	128	12	.	.	PUNCT
arestyrurj-207	129	1	these	these	DET
arestyrurj-207	129	2	genes	gene	NOUN
arestyrurj-207	129	3	are	be	AUX
arestyrurj-207	129	4	potential	potential	ADJ
arestyrurj-207	129	5	ligands	ligand	NOUN
arestyrurj-207	129	6	that	that	PRON
arestyrurj-207	129	7	suppress	suppress	VERB
arestyrurj-207	129	8	mutant	mutant	ADJ
arestyrurj-207	129	9	epithelial	epithelial	ADJ
arestyrurj-207	129	10	growth	growth	NOUN
arestyrurj-207	129	11	.	.	PUNCT
arestyrurj-207	130	1	from	from	ADP
arestyrurj-207	130	2	here	here	ADV
arestyrurj-207	130	3	,	,	PUNCT
arestyrurj-207	130	4	geneticists	geneticist	NOUN
arestyrurj-207	130	5	could	could	AUX
arestyrurj-207	130	6	design	design	VERB
arestyrurj-207	130	7	experiments	experiment	NOUN
arestyrurj-207	130	8	involving	involve	VERB
arestyrurj-207	130	9	blocking	block	VERB
arestyrurj-207	130	10	these	these	DET
arestyrurj-207	130	11	ligands	ligand	NOUN
arestyrurj-207	130	12	with	with	ADP
arestyrurj-207	130	13	antibodies	antibody	NOUN
arestyrurj-207	130	14	or	or	CCONJ
arestyrurj-207	130	15	treatment	treatment	NOUN
arestyrurj-207	130	16	with	with	ADP
arestyrurj-207	130	17	these	these	DET
arestyrurj-207	130	18	ligands	ligand	NOUN
arestyrurj-207	130	19	to	to	PART
arestyrurj-207	130	20	see	see	VERB
arestyrurj-207	130	21	the	the	DET
arestyrurj-207	130	22	epithelial	epithelial	ADJ
arestyrurj-207	130	23	response	response	NOUN
arestyrurj-207	130	24	from	from	ADP
arestyrurj-207	130	25	the	the	DET
arestyrurj-207	130	26	mesenchyme∎	mesenchyme∎	NUM
arestyrurj-207	130	27	5	5	NUM
arestyrurj-207	130	28	references	reference	NOUN
arestyrurj-207	130	29	[	[	X
arestyrurj-207	130	30	1	1	NUM
arestyrurj-207	130	31	]	]	PUNCT
arestyrurj-207	130	32	clevers	clever	NOUN
arestyrurj-207	130	33	,	,	PUNCT
arestyrurj-207	130	34	hans	han	NOUN
arestyrurj-207	130	35	,	,	PUNCT
arestyrurj-207	130	36	and	and	CCONJ
arestyrurj-207	130	37	roel	roel	PROPN
arestyrurj-207	130	38	nusse	nusse	PROPN
arestyrurj-207	130	39	.	.	PUNCT
arestyrurj-207	131	1	“	"	PUNCT
arestyrurj-207	131	2	wnt	wnt	PROPN
arestyrurj-207	131	3	/	/	SYM
arestyrurj-207	131	4	β	β	NOUN
arestyrurj-207	131	5	-	-	ADJ
arestyrurj-207	131	6	catenin	catenin	ADJ
arestyrurj-207	131	7	signaling	signaling	NOUN
arestyrurj-207	131	8	and	and	CCONJ
arestyrurj-207	131	9	disease	disease	NOUN
arestyrurj-207	131	10	.	.	PUNCT
arestyrurj-207	131	11	”	"	PUNCT
arestyrurj-207	131	12	cell	cell	NOUN
arestyrurj-207	131	13	,	,	PUNCT
arestyrurj-207	131	14	cell	cell	NOUN
arestyrurj-207	131	15	press	press	NOUN
arestyrurj-207	131	16	,	,	PUNCT
arestyrurj-207	131	17	7	7	NUM
arestyrurj-207	131	18	june	june	PROPN
arestyrurj-207	131	19	2012	2012	NUM
arestyrurj-207	131	20	,	,	PUNCT
arestyrurj-207	131	21	https://www.sciencedirect.com/science/article/pii/s0092867412005867	https://www.sciencedirect.com/science/article/pii/s0092867412005867	PROPN
arestyrurj-207	131	22	.	.	PUNCT
arestyrurj-207	132	1	[	[	X
arestyrurj-207	132	2	2	2	NUM
arestyrurj-207	132	3	]	]	PUNCT
arestyrurj-207	132	4	mccarthy	mccarthy	PROPN
arestyrurj-207	132	5	,	,	PUNCT
arestyrurj-207	132	6	neil	neil	PROPN
arestyrurj-207	132	7	.	.	PUNCT
arestyrurj-207	133	1	“	"	PUNCT
arestyrurj-207	133	2	distinct	distinct	ADJ
arestyrurj-207	133	3	mesenchymal	mesenchymal	NOUN
arestyrurj-207	133	4	cell	cell	NOUN
arestyrurj-207	133	5	populations	population	NOUN
arestyrurj-207	133	6	generate	generate	VERB
arestyrurj-207	133	7	the	the	DET
arestyrurj-207	133	8	essential	essential	ADJ
arestyrurj-207	133	9	intestinal	intestinal	ADJ
arestyrurj-207	133	10	bmp	bmp	NOUN
arestyrurj-207	133	11	signaling	signal	VERB
arestyrurj-207	133	12	gradient	gradient	NOUN
arestyrurj-207	133	13	.	.	PUNCT
arestyrurj-207	133	14	”	"	PUNCT
arestyrurj-207	134	1	define_me	define_me	PROPN
arestyrurj-207	134	2	,	,	PUNCT
arestyrurj-207	134	3	cell	cell	NOUN
arestyrurj-207	134	4	press	press	NOUN
arestyrurj-207	134	5	,	,	PUNCT
arestyrurj-207	134	6	.	.	PUNCT
arestyrurj-207	135	1	[	[	X
arestyrurj-207	135	2	3	3	X
arestyrurj-207	135	3	]	]	X
arestyrurj-207	135	4	davis	davis	PROPN
arestyrurj-207	135	5	,	,	PUNCT
arestyrurj-207	135	6	hayley	hayley	PROPN
arestyrurj-207	135	7	,	,	PUNCT
arestyrurj-207	135	8	et	et	PROPN
arestyrurj-207	135	9	al	al	PROPN
arestyrurj-207	135	10	.	.	PUNCT
arestyrurj-207	136	1	“	"	PUNCT
arestyrurj-207	136	2	aberrant	aberrant	ADJ
arestyrurj-207	136	3	epithelial	epithelial	ADJ
arestyrurj-207	136	4	grem1	grem1	NOUN
arestyrurj-207	136	5	expression	expression	NOUN
arestyrurj-207	136	6	initiates	initiate	VERB
arestyrurj-207	136	7	colonic	colonic	ADJ
arestyrurj-207	136	8	tumorigenesis	tumorigenesis	NOUN
arestyrurj-207	136	9	from	from	ADP
arestyrurj-207	136	10	cells	cell	NOUN
arestyrurj-207	136	11	outside	outside	ADP
arestyrurj-207	136	12	the	the	DET
arestyrurj-207	136	13	stem	stem	NOUN
arestyrurj-207	136	14	cell	cell	NOUN
arestyrurj-207	136	15	niche	niche	NOUN
arestyrurj-207	136	16	.	.	PUNCT
arestyrurj-207	136	17	”	"	PUNCT
arestyrurj-207	137	1	nature	nature	NOUN
arestyrurj-207	137	2	medicine	medicine	NOUN
arestyrurj-207	137	3	,	,	PUNCT
arestyrurj-207	137	4	u.s	u.s	PROPN
arestyrurj-207	137	5	.	.	PROPN
arestyrurj-207	137	6	national	national	PROPN
arestyrurj-207	137	7	library	library	NOUN
arestyrurj-207	137	8	of	of	ADP
arestyrurj-207	137	9	medicine	medicine	NOUN
arestyrurj-207	137	10	,	,	PUNCT
arestyrurj-207	137	11	jan	jan	PROPN
arestyrurj-207	137	12	.	.	PROPN
arestyrurj-207	137	13	2015	2015	NUM
arestyrurj-207	137	14	,	,	PUNCT
arestyrurj-207	137	15	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4594755/.	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4594755/.	PROPN
arestyrurj-207	138	1	[	[	X
arestyrurj-207	138	2	4	4	NUM
arestyrurj-207	138	3	]	]	PUNCT
arestyrurj-207	138	4	stzepourginski	stzepourginski	NOUN
arestyrurj-207	138	5	,	,	PUNCT
arestyrurj-207	138	6	igor	igor	PROPN
arestyrurj-207	138	7	,	,	PUNCT
arestyrurj-207	138	8	et	et	PROPN
arestyrurj-207	138	9	al	al	PROPN
arestyrurj-207	138	10	.	.	PUNCT
arestyrurj-207	139	1	“	"	PUNCT
arestyrurj-207	139	2	cd34	cd34	PROPN
arestyrurj-207	139	3	+	+	ADJ
arestyrurj-207	139	4	mesenchymal	mesenchymal	ADJ
arestyrurj-207	139	5	cells	cell	NOUN
arestyrurj-207	139	6	are	be	AUX
arestyrurj-207	139	7	a	a	DET
arestyrurj-207	139	8	major	major	ADJ
arestyrurj-207	139	9	component	component	NOUN
arestyrurj-207	139	10	of	of	ADP
arestyrurj-207	139	11	the	the	DET
arestyrurj-207	139	12	intestinal	intestinal	ADJ
arestyrurj-207	139	13	stem	stem	NOUN
arestyrurj-207	139	14	cells	cell	NOUN
arestyrurj-207	139	15	niche	niche	NOUN
arestyrurj-207	139	16	at	at	ADP
arestyrurj-207	139	17	homeostasis	homeostasis	NOUN
arestyrurj-207	139	18	and	and	CCONJ
arestyrurj-207	139	19	after	after	ADP
arestyrurj-207	139	20	injury	injury	NOUN
arestyrurj-207	139	21	.	.	PUNCT
arestyrurj-207	139	22	”	"	PUNCT
arestyrurj-207	140	1	pnas	pnas	PROPN
arestyrurj-207	140	2	,	,	PUNCT
arestyrurj-207	140	3	national	national	PROPN
arestyrurj-207	140	4	academy	academy	PROPN
arestyrurj-207	140	5	of	of	ADP
arestyrurj-207	140	6	sciences	sciences	PROPN
arestyrurj-207	140	7	,	,	PUNCT
arestyrurj-207	140	8	24	24	NUM
arestyrurj-207	140	9	jan	jan	PROPN
arestyrurj-207	140	10	.	.	PROPN
arestyrurj-207	140	11	2017	2017	NUM
arestyrurj-207	140	12	,	,	PUNCT
arestyrurj-207	140	13	https://www.pnas.org/content/114/4/e506	https://www.pnas.org/content/114/4/e506	NOUN
arestyrurj-207	140	14	.	.	PUNCT
arestyrurj-207	141	1	[	[	X
arestyrurj-207	141	2	5	5	NUM
arestyrurj-207	141	3	]	]	X
arestyrurj-207	141	4	perekatt	perekatt	NOUN
arestyrurj-207	141	5	,	,	PUNCT
arestyrurj-207	141	6	ansu	ansu	PROPN
arestyrurj-207	141	7	o.	o.	PROPN
arestyrurj-207	141	8	,	,	PUNCT
arestyrurj-207	141	9	et	et	PROPN
arestyrurj-207	141	10	al	al	PROPN
arestyrurj-207	141	11	.	.	PUNCT
arestyrurj-207	142	1	“	"	PUNCT
arestyrurj-207	142	2	smad4	smad4	NOUN
arestyrurj-207	142	3	suppresses	suppress	VERB
arestyrurj-207	142	4	wnt	wnt	PROPN
arestyrurj-207	142	5	-	-	PUNCT
arestyrurj-207	142	6	driven	drive	VERB
arestyrurj-207	142	7	dedifferentiation	dedifferentiation	NOUN
arestyrurj-207	142	8	and	and	CCONJ
arestyrurj-207	142	9	oncogenesis	oncogenesis	NOUN
arestyrurj-207	142	10	in	in	ADP
arestyrurj-207	142	11	the	the	DET
arestyrurj-207	142	12	differentiated	differentiated	ADJ
arestyrurj-207	142	13	gut	gut	NOUN
arestyrurj-207	142	14	epithelium	epithelium	NOUN
arestyrurj-207	142	15	.	.	PUNCT
arestyrurj-207	142	16	”	"	PUNCT
arestyrurj-207	143	1	cancer	cancer	NOUN
arestyrurj-207	143	2	research	research	NOUN
arestyrurj-207	143	3	,	,	PUNCT
arestyrurj-207	143	4	american	american	PROPN
arestyrurj-207	143	5	association	association	PROPN
arestyrurj-207	143	6	for	for	ADP
arestyrurj-207	143	7	cancer	cancer	NOUN
arestyrurj-207	143	8	research	research	NOUN
arestyrurj-207	143	9	,	,	PUNCT
arestyrurj-207	143	10	1	1	NUM
arestyrurj-207	143	11	sept	sept	PROPN
arestyrurj-207	143	12	.	.	PROPN
arestyrurj-207	143	13	2018	2018	NUM
arestyrurj-207	143	14	,	,	PUNCT
arestyrurj-207	143	15	https://cancerres.aacrjournals.org/content/78/17/4878	https://cancerres.aacrjournals.org/content/78/17/4878	PROPN
arestyrurj-207	143	16	#	#	NOUN
arestyrurj-207	143	17	.	.	PUNCT
arestyrurj-207	144	1	[	[	X
arestyrurj-207	144	2	6	6	NUM
arestyrurj-207	144	3	]	]	X
arestyrurj-207	144	4	el	el	PROPN
arestyrurj-207	144	5	marjou	marjou	PROPN
arestyrurj-207	144	6	,	,	PUNCT
arestyrurj-207	144	7	fatima	fatima	PROPN
arestyrurj-207	144	8	.	.	PUNCT
arestyrurj-207	145	1	“	"	PUNCT
arestyrurj-207	145	2	tissue	tissue	NOUN
arestyrurj-207	145	3	-	-	PUNCT
arestyrurj-207	145	4	specific	specific	ADJ
arestyrurj-207	145	5	and	and	CCONJ
arestyrurj-207	145	6	inducible	inducible	ADJ
arestyrurj-207	145	7	cre	cre	PROPN
arestyrurj-207	145	8	-	-	PUNCT
arestyrurj-207	145	9	mediated	mediate	VERB
arestyrurj-207	145	10	recombination	recombination	NOUN
arestyrurj-207	145	11	in	in	ADP
arestyrurj-207	145	12	the	the	DET
arestyrurj-207	145	13	gut	gut	NOUN
arestyrurj-207	145	14	epithelium	epithelium	NOUN
arestyrurj-207	145	15	.	.	PUNCT
arestyrurj-207	145	16	”	"	PUNCT
arestyrurj-207	146	1	genesis	genesis	NOUN
arestyrurj-207	146	2	(	(	PUNCT
arestyrurj-207	146	3	new	new	PROPN
arestyrurj-207	146	4	york	york	PROPN
arestyrurj-207	146	5	,	,	PUNCT
arestyrurj-207	146	6	n.y	n.y	PROPN
arestyrurj-207	146	7	.	.	PROPN
arestyrurj-207	146	8	:	:	PUNCT
arestyrurj-207	146	9	2000	2000	NUM
arestyrurj-207	146	10	)	)	PUNCT
arestyrurj-207	146	11	,	,	PUNCT
arestyrurj-207	146	12	u.s	u.s	PROPN
arestyrurj-207	146	13	.	.	PROPN
arestyrurj-207	146	14	national	national	PROPN
arestyrurj-207	146	15	library	library	NOUN
arestyrurj-207	146	16	of	of	ADP
arestyrurj-207	146	17	medicine	medicine	NOUN
arestyrurj-207	146	18	,	,	PUNCT
arestyrurj-207	146	19	july	july	PROPN
arestyrurj-207	146	20	2004	2004	NUM
arestyrurj-207	146	21	,	,	PUNCT
arestyrurj-207	146	22	https://pubmed.ncbi.nlm.nih.gov/15282745/.	https://pubmed.ncbi.nlm.nih.gov/15282745/.	PROPN
arestyrurj-207	146	23	[	[	X
arestyrurj-207	146	24	7	7	X
arestyrurj-207	146	25	]	]	X
arestyrurj-207	146	26	qi	qi	PROPN
arestyrurj-207	146	27	,	,	PUNCT
arestyrurj-207	146	28	zhen	zhen	PROPN
arestyrurj-207	146	29	,	,	PUNCT
arestyrurj-207	146	30	et	et	PROPN
arestyrurj-207	146	31	al	al	PROPN
arestyrurj-207	146	32	.	.	PUNCT
arestyrurj-207	147	1	“	"	PUNCT
arestyrurj-207	147	2	bmp	bmp	PROPN
arestyrurj-207	147	3	restricts	restrict	VERB
arestyrurj-207	147	4	stemness	stemness	NOUN
arestyrurj-207	147	5	of	of	ADP
arestyrurj-207	147	6	intestinal	intestinal	ADJ
arestyrurj-207	147	7	lgr5	lgr5	NOUN
arestyrurj-207	147	8	+	+	CCONJ
arestyrurj-207	147	9	stem	stem	NOUN
arestyrurj-207	147	10	cells	cell	NOUN
arestyrurj-207	147	11	by	by	ADP
arestyrurj-207	147	12	directly	directly	ADV
arestyrurj-207	147	13	suppressing	suppress	VERB
arestyrurj-207	147	14	their	their	PRON
arestyrurj-207	147	15	signature	signature	NOUN
arestyrurj-207	147	16	genes	gene	NOUN
arestyrurj-207	147	17	.	.	PUNCT
arestyrurj-207	147	18	”	"	PUNCT
arestyrurj-207	148	1	nature	nature	NOUN
arestyrurj-207	148	2	news	news	PROPN
arestyrurj-207	148	3	,	,	PUNCT
arestyrurj-207	148	4	nature	nature	NOUN
arestyrurj-207	148	5	publishing	publishing	NOUN
arestyrurj-207	148	6	group	group	NOUN
arestyrurj-207	148	7	,	,	PUNCT
arestyrurj-207	148	8	6	6	NUM
arestyrurj-207	148	9	jan	jan	PROPN
arestyrurj-207	148	10	.	.	PROPN
arestyrurj-207	148	11	2017	2017	NUM
arestyrurj-207	148	12	,	,	PUNCT
arestyrurj-207	148	13	https://www.nature.com/articles/ncomms13824	https://www.nature.com/articles/ncomms13824	NOUN
arestyrurj-207	148	14	.	.	PUNCT
arestyrurj-207	149	1	[	[	X
arestyrurj-207	149	2	8	8	NUM
arestyrurj-207	149	3	]	]	X
arestyrurj-207	149	4	zhang	zhang	PROPN
arestyrurj-207	149	5	,	,	PUNCT
arestyrurj-207	149	6	ya	ya	PROPN
arestyrurj-207	149	7	,	,	PUNCT
arestyrurj-207	149	8	and	and	CCONJ
arestyrurj-207	149	9	xin	xin	PROPN
arestyrurj-207	149	10	wang	wang	PROPN
arestyrurj-207	149	11	.	.	PUNCT
arestyrurj-207	150	1	“	"	PUNCT
arestyrurj-207	150	2	targeting	target	VERB
arestyrurj-207	150	3	the	the	DET
arestyrurj-207	150	4	wnt	wnt	NOUN
arestyrurj-207	150	5	/	/	SYM
arestyrurj-207	150	6	βcatenin	βcatenin	NOUN
arestyrurj-207	150	7	signaling	signal	VERB
arestyrurj-207	150	8	pathway	pathway	NOUN
arestyrurj-207	150	9	in	in	ADP
arestyrurj-207	150	10	cancer	cancer	NOUN
arestyrurj-207	150	11	journal	journal	NOUN
arestyrurj-207	150	12	of	of	ADP
arestyrurj-207	150	13	hematology	hematology	PROPN
arestyrurj-207	150	14	&	&	CCONJ
arestyrurj-207	150	15	oncology	oncology	NOUN
arestyrurj-207	150	16	.	.	PUNCT
arestyrurj-207	150	17	”	"	PUNCT
arestyrurj-207	150	18	biomed	biome	VERB
arestyrurj-207	150	19	central	central	ADJ
arestyrurj-207	150	20	,	,	PUNCT
arestyrurj-207	150	21	biomed	biome	VERB
arestyrurj-207	150	22	central	central	ADJ
arestyrurj-207	150	23	,	,	PUNCT
arestyrurj-207	150	24	4	4	NUM
arestyrurj-207	150	25	dec	dec	PROPN
arestyrurj-207	150	26	.	.	PROPN
arestyrurj-207	150	27	2020	2020	NUM
arestyrurj-207	150	28	,	,	PUNCT
arestyrurj-207	150	29	https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-009903	https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-009903	NOUN
arestyrurj-207	150	30	.	.	PUNCT
arestyrurj-207	151	1	[	[	X
arestyrurj-207	151	2	9	9	NUM
arestyrurj-207	151	3	]	]	X
arestyrurj-207	151	4	wang	wang	PROPN
arestyrurj-207	151	5	,	,	PUNCT
arestyrurj-207	151	6	li	li	PROPN
arestyrurj-207	151	7	,	,	PUNCT
arestyrurj-207	151	8	et	et	PROPN
arestyrurj-207	151	9	al	al	PROPN
arestyrurj-207	151	10	.	.	PUNCT
arestyrurj-207	152	1	“	"	PUNCT
arestyrurj-207	152	2	areg	areg	NOUN
arestyrurj-207	152	3	mediates	mediate	VERB
arestyrurj-207	152	4	the	the	DET
arestyrurj-207	152	5	epithelialmesenchymal	epithelialmesenchymal	ADJ
arestyrurj-207	152	6	transition	transition	NOUN
arestyrurj-207	152	7	in	in	ADP
arestyrurj-207	152	8	pancreatic	pancreatic	ADJ
arestyrurj-207	152	9	cancer	cancer	NOUN
arestyrurj-207	152	10	cells	cell	NOUN
arestyrurj-207	152	11	via	via	ADP
arestyrurj-207	152	12	the	the	DET
arestyrurj-207	152	13	egfr	egfr	PROPN
arestyrurj-207	152	14	/	/	SYM
arestyrurj-207	152	15	erk	erk	PROPN
arestyrurj-207	152	16	/	/	PUNCT
arestyrurj-207	152	17	nf	nf	NOUN
arestyrurj-207	152	18	-	-	PUNCT
arestyrurj-207	152	19	κb	κb	NOUN
arestyrurj-207	152	20	signalling	signal	VERB
arestyrurj-207	152	21	pathway	pathway	NOUN
arestyrurj-207	152	22	.	.	PUNCT
arestyrurj-207	152	23	”	"	PUNCT
arestyrurj-207	153	1	oncology	oncology	NOUN
arestyrurj-207	153	2	reports	report	NOUN
arestyrurj-207	153	3	,	,	PUNCT
arestyrurj-207	153	4	d.a	d.a	PROPN
arestyrurj-207	153	5	.	.	PROPN
arestyrurj-207	153	6	spandidos	spandido	NOUN
arestyrurj-207	153	7	,	,	PUNCT
arestyrurj-207	153	8	may	may	AUX
arestyrurj-207	153	9	2020	2020	NUM
arestyrurj-207	153	10	,	,	PUNCT
arestyrurj-207	153	11	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7107775/.	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7107775/.	PROPN
arestyrurj-207	154	1	[	[	X
arestyrurj-207	154	2	10	10	NUM
arestyrurj-207	154	3	]	]	X
arestyrurj-207	154	4	fevr	fevr	PROPN
arestyrurj-207	154	5	,	,	PUNCT
arestyrurj-207	154	6	tea	tea	NOUN
arestyrurj-207	154	7	,	,	PUNCT
arestyrurj-207	154	8	et	et	PROPN
arestyrurj-207	154	9	al	al	PROPN
arestyrurj-207	154	10	.	.	PUNCT
arestyrurj-207	155	1	“	"	PUNCT
arestyrurj-207	155	2	wnt	wnt	PROPN
arestyrurj-207	155	3	/	/	SYM
arestyrurj-207	155	4	beta	beta	NOUN
arestyrurj-207	155	5	-	-	PUNCT
arestyrurj-207	155	6	catenin	catenin	NOUN
arestyrurj-207	155	7	is	be	AUX
arestyrurj-207	155	8	essential	essential	ADJ
arestyrurj-207	155	9	for	for	ADP
arestyrurj-207	155	10	intestinal	intestinal	ADJ
arestyrurj-207	155	11	homeostasis	homeostasis	NOUN
arestyrurj-207	155	12	and	and	CCONJ
arestyrurj-207	155	13	maintenance	maintenance	NOUN
arestyrurj-207	155	14	of	of	ADP
arestyrurj-207	155	15	intestinal	intestinal	ADJ
arestyrurj-207	155	16	stem	stem	NOUN
arestyrurj-207	155	17	cells	cell	NOUN
arestyrurj-207	155	18	.	.	PUNCT
arestyrurj-207	155	19	”	"	PUNCT
arestyrurj-207	156	1	molecular	molecular	ADJ
arestyrurj-207	156	2	and	and	CCONJ
arestyrurj-207	156	3	cellular	cellular	ADJ
arestyrurj-207	156	4	biology	biology	NOUN
arestyrurj-207	156	5	,	,	PUNCT
arestyrurj-207	156	6	american	american	ADJ
arestyrurj-207	156	7	society	society	NOUN
arestyrurj-207	156	8	for	for	ADP
arestyrurj-207	156	9	microbiology	microbiology	NOUN
arestyrurj-207	156	10	(	(	PUNCT
arestyrurj-207	156	11	asm	asm	NOUN
arestyrurj-207	156	12	)	)	PUNCT
arestyrurj-207	156	13	,	,	PUNCT
arestyrurj-207	156	14	nov	nov	PROPN
arestyrurj-207	156	15	.	.	PROPN
arestyrurj-207	156	16	2007	2007	NUM
arestyrurj-207	156	17	,	,	PUNCT
arestyrurj-207	156	18	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2169070/.	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2169070/.	NOUN
arestyrurj-207	157	1	[	[	X
arestyrurj-207	157	2	11	11	NUM
arestyrurj-207	157	3	]	]	X
arestyrurj-207	157	4	tissue‐specific	tissue‐specific	NOUN
arestyrurj-207	157	5	and	and	CCONJ
arestyrurj-207	157	6	inducible	inducible	ADJ
arestyrurj-207	157	7	cre‐mediated	cre‐mediate	VERB
arestyrurj-207	157	8	...	...	PUNCT
arestyrurj-207	157	9	wiley	wiley	PROPN
arestyrurj-207	157	10	online	online	PROPN
arestyrurj-207	157	11	library	library	PROPN
arestyrurj-207	157	12	.	.	PUNCT
arestyrurj-207	158	1	https://doi.org/10.1002/gene.20042	https://doi.org/10.1002/gene.20042	NUM
arestyrurj-207	158	2	.	.	PUNCT
arestyrurj-207	159	1	[	[	X
arestyrurj-207	159	2	12	12	NUM
arestyrurj-207	159	3	]	]	X
arestyrurj-207	159	4	harada	harada	PROPN
arestyrurj-207	159	5	n;tamai	n;tamai	PROPN
arestyrurj-207	159	6	y;ishikawa	y;ishikawa	NOUN
arestyrurj-207	159	7	t;sauer	t;sauer	PUNCT
arestyrurj-207	159	8	b;takaku	b;takaku	PROPN
arestyrurj-207	159	9	k;oshima	k;oshima	PROPN
arestyrurj-207	159	10	m;taketo	m;taketo	PROPN
arestyrurj-207	159	11	mm	mm	PROPN
arestyrurj-207	159	12	;	;	PUNCT
arestyrurj-207	159	13	“	"	PUNCT
arestyrurj-207	159	14	intestinal	intestinal	ADJ
arestyrurj-207	159	15	polyposis	polyposis	NOUN
arestyrurj-207	159	16	in	in	ADP
arestyrurj-207	159	17	mice	mouse	NOUN
arestyrurj-207	159	18	with	with	ADP
arestyrurj-207	159	19	a	a	DET
arestyrurj-207	159	20	dominant	dominant	ADJ
arestyrurj-207	159	21	stable	stable	ADJ
arestyrurj-207	159	22	mutation	mutation	NOUN
arestyrurj-207	159	23	of	of	ADP
arestyrurj-207	159	24	the	the	DET
arestyrurj-207	159	25	beta	beta	NOUN
arestyrurj-207	159	26	-	-	PUNCT
arestyrurj-207	159	27	catenin	catenin	NOUN
arestyrurj-207	159	28	gene	gene	NOUN
arestyrurj-207	159	29	.	.	PUNCT
arestyrurj-207	159	30	”	"	PUNCT
arestyrurj-207	160	1	the	the	DET
arestyrurj-207	160	2	embo	embo	PROPN
arestyrurj-207	160	3	journal	journal	PROPN
arestyrurj-207	160	4	,	,	PUNCT
arestyrurj-207	160	5	u.s	u.s	PROPN
arestyrurj-207	160	6	.	.	PROPN
arestyrurj-207	160	7	national	national	PROPN
arestyrurj-207	160	8	library	library	NOUN
arestyrurj-207	160	9	of	of	ADP
arestyrurj-207	160	10	medicine	medicine	NOUN
arestyrurj-207	160	11	,	,	PUNCT
arestyrurj-207	160	12	https://pubmed.ncbi.nlm.nih.gov/10545105/.	https://pubmed.ncbi.nlm.nih.gov/10545105/.	PRON
arestyrurj-207	160	13	https://www.sciencedirect.com/science/article/pii/s0092867412005867	https://www.sciencedirect.com/science/article/pii/s0092867412005867	PROPN
arestyrurj-207	160	14	https://www.sciencedirect.com/science/article/pii/s0092867412005867	https://www.sciencedirect.com/science/article/pii/s0092867412005867	PROPN
arestyrurj-207	160	15	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4594755/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4594755/	PROPN
arestyrurj-207	160	16	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4594755/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4594755/	PROPN
arestyrurj-207	160	17	https://www.pnas.org/content/114/4/e506	https://www.pnas.org/content/114/4/e506	NOUN
arestyrurj-207	160	18	https://cancerres.aacrjournals.org/content/78/17/4878	https://cancerres.aacrjournals.org/content/78/17/4878	PROPN
arestyrurj-207	160	19	https://cancerres.aacrjournals.org/content/78/17/4878	https://cancerres.aacrjournals.org/content/78/17/4878	PROPN
arestyrurj-207	160	20	https://pubmed.ncbi.nlm.nih.gov/15282745/	https://pubmed.ncbi.nlm.nih.gov/15282745/	PROPN
arestyrurj-207	160	21	https://pubmed.ncbi.nlm.nih.gov/15282745/	https://pubmed.ncbi.nlm.nih.gov/15282745/	PROPN
arestyrurj-207	160	22	https://www.nature.com/articles/ncomms13824	https://www.nature.com/articles/ncomms13824	PROPN
arestyrurj-207	160	23	https://www.nature.com/articles/ncomms13824	https://www.nature.com/articles/ncomms13824	PROPN
arestyrurj-207	160	24	https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00990-3	https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00990-3	PROPN
arestyrurj-207	160	25	https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00990-3	https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00990-3	NOUN
arestyrurj-207	160	26	https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00990-3	https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00990-3	NOUN
arestyrurj-207	160	27	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7107775/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7107775/	NOUN
arestyrurj-207	160	28	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7107775/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7107775/	NOUN
arestyrurj-207	160	29	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2169070/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2169070/	PROPN
arestyrurj-207	160	30	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2169070/	https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2169070/	PROPN
arestyrurj-207	160	31	https://doi.org/10.1002/gene.20042	https://doi.org/10.1002/gene.20042	PROPN
arestyrurj-207	160	32	https://pubmed.ncbi.nl/	https://pubmed.ncbi.nl/	VERB
arestyrurj-207	160	33	https://pubmed.ncbi.nlm.nih.gov/10545105/	https://pubmed.ncbi.nlm.nih.gov/10545105/	PROPN
arestyrurj-207	160	34	aresty	aresty	ADJ
arestyrurj-207	160	35	rutgers	rutgers	PROPN
arestyrurj-207	160	36	undergraduate	undergraduate	PROPN
arestyrurj-207	160	37	research	research	PROPN
arestyrurj-207	160	38	journal	journal	PROPN
arestyrurj-207	160	39	,	,	PUNCT
arestyrurj-207	160	40	volume	volume	NOUN
arestyrurj-207	160	41	i	i	PRON
arestyrurj-207	160	42	,	,	PUNCT
arestyrurj-207	160	43	issue	issue	NOUN
arestyrurj-207	160	44	iv	iv	NUM
arestyrurj-207	160	45	jay	jay	PROPN
arestyrurj-207	160	46	patel	patel	PROPN
arestyrurj-207	160	47	is	be	AUX
arestyrurj-207	160	48	a	a	DET
arestyrurj-207	160	49	junior	junior	ADJ
arestyrurj-207	160	50	undergraduate	undergraduate	NOUN
arestyrurj-207	160	51	student	student	NOUN
arestyrurj-207	160	52	conducting	conduct	VERB
arestyrurj-207	160	53	research	research	NOUN
arestyrurj-207	160	54	in	in	ADP
arestyrurj-207	160	55	the	the	DET
arestyrurj-207	160	56	genetics	genetics	PROPN
arestyrurj-207	160	57	department	department	NOUN
arestyrurj-207	160	58	at	at	ADP
arestyrurj-207	160	59	rutgers	rutgers	PROPN
arestyrurj-207	160	60	new	new	PROPN
arestyrurj-207	160	61	brunswick	brunswick	PROPN
arestyrurj-207	160	62	.	.	PUNCT
arestyrurj-207	161	1	his	his	PRON
arestyrurj-207	161	2	interest	interest	NOUN
arestyrurj-207	161	3	in	in	ADP
arestyrurj-207	161	4	scientific	scientific	ADJ
arestyrurj-207	161	5	research	research	NOUN
arestyrurj-207	161	6	was	be	AUX
arestyrurj-207	161	7	sparked	spark	VERB
arestyrurj-207	161	8	by	by	ADP
arestyrurj-207	161	9	his	his	PRON
arestyrurj-207	161	10	experience	experience	NOUN
arestyrurj-207	161	11	with	with	ADP
arestyrurj-207	161	12	the	the	DET
arestyrurj-207	161	13	rutgers	rutgers	PROPN
arestyrurj-207	161	14	waksman	waksman	PROPN
arestyrurj-207	161	15	program	program	PROPN
arestyrurj-207	161	16	,	,	PUNCT
arestyrurj-207	161	17	during	during	ADP
arestyrurj-207	161	18	his	his	PRON
arestyrurj-207	161	19	time	time	NOUN
arestyrurj-207	161	20	in	in	ADP
arestyrurj-207	161	21	high	high	ADJ
arestyrurj-207	161	22	school	school	NOUN
arestyrurj-207	161	23	.	.	PUNCT
arestyrurj-207	162	1	he	he	PRON
arestyrurj-207	162	2	currently	currently	ADV
arestyrurj-207	162	3	works	work	VERB
arestyrurj-207	162	4	with	with	ADP
arestyrurj-207	162	5	dr	dr	PROPN
arestyrurj-207	162	6	.	.	PROPN
arestyrurj-207	162	7	verzi	verzi	PROPN
arestyrurj-207	162	8	and	and	CCONJ
arestyrurj-207	162	9	his	his	PRON
arestyrurj-207	162	10	mentor	mentor	NOUN
arestyrurj-207	162	11	,	,	PUNCT
arestyrurj-207	162	12	oscar	oscar	PROPN
arestyrurj-207	162	13	,	,	PUNCT
arestyrurj-207	162	14	where	where	SCONJ
arestyrurj-207	162	15	they	they	PRON
arestyrurj-207	162	16	investigate	investigate	VERB
arestyrurj-207	162	17	the	the	DET
arestyrurj-207	162	18	pathway	pathway	NOUN
arestyrurj-207	162	19	by	by	ADP
arestyrurj-207	162	20	which	which	PRON
arestyrurj-207	162	21	the	the	DET
arestyrurj-207	162	22	intestinal	intestinal	ADJ
arestyrurj-207	162	23	epithelium	epithelium	NOUN
arestyrurj-207	162	24	and	and	CCONJ
arestyrurj-207	162	25	mesenchymal	mesenchymal	ADJ
arestyrurj-207	162	26	cell	cell	NOUN
arestyrurj-207	162	27	populations	population	NOUN
arestyrurj-207	162	28	are	be	AUX
arestyrurj-207	162	29	communicating	communicate	VERB
arestyrurj-207	162	30	.	.	PUNCT
arestyrurj-207	163	1	along	along	ADP
arestyrurj-207	163	2	with	with	ADP
arestyrurj-207	163	3	being	be	AUX
arestyrurj-207	163	4	a	a	DET
arestyrurj-207	163	5	researcher	researcher	NOUN
arestyrurj-207	163	6	,	,	PUNCT
arestyrurj-207	163	7	jay	jay	PROPN
arestyrurj-207	163	8	also	also	ADV
arestyrurj-207	163	9	enjoys	enjoy	VERB
arestyrurj-207	163	10	riding	ride	VERB
arestyrurj-207	163	11	as	as	ADP
arestyrurj-207	163	12	an	an	DET
arestyrurj-207	163	13	emt	emt	NOUN
arestyrurj-207	163	14	and	and	CCONJ
arestyrurj-207	163	15	the	the	DET
arestyrurj-207	163	16	highland	highland	PROPN
arestyrurj-207	163	17	park	park	PROPN
arestyrurj-207	163	18	first	first	PROPN
arestyrurj-207	163	19	aid	aid	NOUN
arestyrurj-207	163	20	squad	squad	NOUN
arestyrurj-207	163	21	,	,	PUNCT
arestyrurj-207	163	22	volunteering	volunteer	VERB
arestyrurj-207	163	23	as	as	ADP
arestyrurj-207	163	24	a	a	DET
arestyrurj-207	163	25	part	part	NOUN
arestyrurj-207	163	26	of	of	ADP
arestyrurj-207	163	27	the	the	DET
arestyrurj-207	163	28	rutgers	rutgers	PROPN
arestyrurj-207	163	29	red	red	PROPN
arestyrurj-207	163	30	cross	cross	PROPN
arestyrurj-207	163	31	,	,	PUNCT
arestyrurj-207	163	32	and	and	CCONJ
arestyrurj-207	163	33	playing	play	VERB
arestyrurj-207	163	34	basketball	basketball	NOUN
arestyrurj-207	163	35	with	with	ADP
arestyrurj-207	163	36	his	his	PRON
arestyrurj-207	163	37	friends	friend	NOUN
arestyrurj-207	163	38	.	.	PUNCT