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International Medical Scientific Journal     Issue-2 

10.5281/zenodo.5109227 

47 

    



Art of Medicine         Volume-1 

International Medical Scientific Journal     Issue-2 

10.5281/zenodo.5109227 

48 

Art of Medicine International Medical Scientific journal 

 

Founder and Publisher Pascual Izquierdo-Egea 

Published science may 2021 year. Issued Quarterly. 

Internet address: http://artofmedicineimsj.us 

E-mail: info@artofmedicineimsj.us 

11931 Barlow Pl Philadelphia, PA 19116, USA +1 (929) 266-0862 

 

 

 

 



Art of Medicine         Volume-1 

International Medical Scientific Journal     Issue-2 

10.5281/zenodo.5109227 

49 

PREPARATIONS ON LONGITUDINAL DEFORMATION OF THE LEFT 

VENTRICLE 

Mamurov O.I. Gafur-Akhunov M.A. Dadamyants N.G.  

Tashkent Institute for Advanced Training of Doctors, Republican Scientific Center 

for Emergency Medical Purpose Tashkent, Uzbekistan 
 

Abstract 

To compare the indicators of longitudinal deformation of the left ventricular 
myocardium and the rate of deformation of the LV myocardium in women before 

and after receiving anthracyclines chemotherapy in breast cancer(BC) patients 

Keywords: myocardium, left ventricle, oncological, cardiovascular, treatment. 

 
Introduction. Currently, there is a steady trend towards an increase in the 

incidence of malignant neoplasms (MNO) in the world [1]. In Russia, the increase 

in newly diagnosed malignant neoplasms for ten years exceeded 20% [2]. At the 
same time, early diagnosis and improving approaches to the treatment of cancer 

patients have significantly increased their survival [3]. Today in the world there are 

several tens of millions of people receiving treatment for cancer, and the so-called 

oncological centenarians. According to estimates, their number will progressively 
increase. [4].  

Oncological and cardiovascular diseases are often a comorbid pathology, the 

development of which is facilitated by common risk factors, such as old age, 

smoking, obesity, and a sedentary lifestyle [5]. The mutual influence and 
strengthening of a number of pathogenetic mechanisms are also important, in 

particular inflammation, oxidative stress, endothelial dysfunction, impaired 

apoptosis, dysregulation of angiogenesis, epigenetic and other factors [6]. Perhaps 
the maximum contribution to the development of cardiovascular pathology in 

cancer patients is made by the toxic effects of anticancer therapy. 

One of the most significant cardiovascular complications (CVC) of anticancer 

treatment is left ventricular (LV) dysfunction - a decrease in LV ejection fraction 
(EF) by more than 10 percentage points from the initial value and below 50% [7, 

8] and heart failure ( CH). LV and HF dysfunction associated with anticancer 

therapy can lead to its interruption or premature withdrawal and thereby reduce the 
chances of cure. Being a late manifestation of cardiotoxicity of anticancer therapy, 

HF can not only worsen the quality of life, but also significantly affect the 

prognosis of patients successfully treated for Cancer. The overall mortality rate of 

patients with HF (6%) is ten times higher than the population one [9]. Studies of 
both past and recent years indicate that patients with late onset HF associated with 

anticancer therapy (more than five years after its completion) have a poorer 

prognosis than patients with HF due to other causes. [10]. 
Materials and methods. Patients received from 6 to 12 courses of chemotherapy. 

22 patients were studied (mean age 48.8 ± 10.9 years) Depending on the 

chemotherapy option, the patients were divided into 2 groups: 1st (n = 12) 



Art of Medicine         Volume-1 

International Medical Scientific Journal     Issue-2 

10.5281/zenodo.5109227 

50 

treatment duration of 8 weeks or less, the cumulative dosage of doxorubicin was 
360 mg / m2; 2nd (n = 10) duration of treatment 16 weeks, cumulative dosage of 

doxorubicin 500 mg / m2. All patients underwent echocardiography before and 

after chemotherapy. Echocardiographic examination was performed on a Vivid 

S70N (GE Health Care) using an M5Sc 1,7-3,0 МHz matrix transducer. All 
participants in the study underwent an assessment of the longitudinal deformation 

of the LV myocardium using the 2D Strain method. Data analysis was performed 

off line. 
Results. In patients who received a higher cumulative dose of doxorubicin (group 

2), there was a statistically significant increase in myocardial injury, a decrease in 

the global longitudinal strain of the left ventricle according to two-dimensional 

speckle-tracking echocardiography (from -18,6±0,4 to -14,8±0,4%; p<0,05)  
Conclusions. An increased risk of developing subclinical cardiotoxicity was 

associated with a higher cumulative dose of doxorubicin (500 mg / m2) in breast 

cancer patients. On echocardiography, a decrease in longitudinal LV deformity is 
observed, this indicates a high cardiotoxicity of the drug and requires corrective 

therapy.  


