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International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5848882 

6 

  



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5848882 

7 

 

 
 

 

 

Art of Medicine International Medical Scientific journal 

 

Founder and Publisher Pascual Izquierdo-Egea 

Published science may 2021 year. Issued Quarterly. 
Internet address: http://artofmedicineimsj.us 

E-mail: info@artofmedicineimsj.us 

11931 Barlow Pl Philadelphia, PA 19116, USA +1 (929) 266-0862 

 

 
  



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5848882 

8 

CHARACTERISTICS OF THE CARDIOVASCULAR SYSTEM DYNAMICS 

IN WOMEN WORKING AT THE NAVOI SILKWORM  PLANT AND THE 

RISK OF DEVELOPING PRE-PATHOLIC CONDITIONS 

Iskandarov Aziz Bakhromovich 

Doctor of Philosophy (Ph.D.) in Medical Sciences, Senior Researcher of the 

Scientific Research Institute of Sanitation, Hygiene and Occupational Diseases of the 

Ministry of Health of the Republic of Uzbekistan 

Abstract: Working conditions and the character of labor processes in the 

silkworm industry cause unfavorable changes in the parameters of the cardiovascular 

system in female workers; the most expressed negative effect on the functional state 

of the cardiovascular system is produced by the temperature factor (coefficient of 

determination 96.1% average in all indexes of hemodynamics, coefficient of 

elasticity 0.065-0.2%). Calculation of correlation, determination and elasticity 

coefficients makes it possible to predict the risk of pre-pathological conditions, which 

allows substantiating measures to reduce the adverse effects of production factors on 

the body of workers.  

Keywords: silkworm  production, working conditions, cardiovascular system.  

In Uzbekistan, the output of natural silk increases from year to year, which is 

associated with the development of mulberry silkworm production, where breeding 

caterpillars of mulberry silkworms are grown and get a highly productive elite green. 

Over the past few years, more than 2 times increased the volume of production 

of domestic productive breeds of mulberry silkworms, from which grow cocoons.  

Uzbekistan ranks 4th in the world after China, Vietnam, and India's production 

of live cocoons. Increased production of mulberry silkworm cocoons is directly 

related to the development of silkworm industries. Currently, 17 silkworm plants and 

3 breeding silk stations are operating in Uzbekistan. Mainly women work in the 

silkworm industry. One of the largest silkworm productions in Uzbekistan is the 

Navoi silkworm plant, where within the grant project ATSS-24.6 "Development of 

new methodology of forecasting and prevention of professionally caused pre-

pathological conditions at women working at agricultural silkworm productions of 

Uzbekistan," the studies on working conditions and their influence on the functional 

condition of different systems of the organism, including the cardiovascular system, 

were conducted. 

The research aimed to reveal the influence of working conditions of female 

workers of the silkworm production on the functional state of the cardiovascular 

system. 

Research methods. Working conditions were studied by traditional methods, 

using an aspirator, psychrometer, anemometer, noise meter, luxmeter according to the 



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5848882 

9 

requirements of Sanitary rules, norms and hygienic norms of the Republic of 

Uzbekistan №№ 0294-11 [2], 0325-16 [3], 0141-03 [4], 0324-16 [5], building norms 

and rules 2.01.05-96 [8], and a technique "Labour conditions assessment technique 

and the certification of work places by working conditions" [7].  

Hemodynamic indices studied the functional state of the cardiovascular system: pulse 

rate was counted by the palpatory method on the radial artery, and arterial pressure 

level was measured by Korotkoff's sonic method. The heart's systolic and minute 

volumes (SB and MOS) were determined using calculation methods according to the 

Stahr formula. The Hickam formula calculated the mean dynamic pressure and 

peripheral resistance in capillaries [6]. All measurements were made directly at the 

workplaces before the beginning of work (baseline values), before the lunch break 

and at the end of the working day.  

Research results. Studies have shown that one of grenade production's leading 

adverse production factors is papilionage dust, which has allergenic properties [1]. 

Papilionage dust is formed during papilionage (mating of butterflies) when scales are 

separated from the wings of many moths, which fly around in the air. Dust from 

moths consists of 75-80% of organic substances of animal origin (the smallest 

chitinous scales) and contains a small amount (about 0.01%) of protein substances. 

Dimensions of 90-95% of the dust particles are up to 10 microns. They have an 

irregular shape with pointed edges and long spikes. Research materials showed that 

the dustiness of papillary dust during different technological operations varies from 

3.43±0.13 to 12.05±0.57mg/m3. In addition, the air of the working area of the 

silkworm plant is polluted by products of activity of pupae and butterflies of 

mulberry silkworm: ammonia (NH3), hydrogen sulfide (H2S) and carbon monoxide 

(CO). Average ammonia concentrations exceeded MPC by 1.06-1.07 times, hydrogen 

sulfide by 1.12-1.31 times, carbon oxide by 1.11 times. 

Air temperature at the working places of papilionazhnits fluctuated in the 

dynamics of a working day from 28,8±0,45 to 32,04±0,23оС on the average, relative 

humidity from 33,0 to 62,4%, air speed was insignificant -0,12±0,002 m/s. 

Illumination of working surfaces in the papilion workshop during the dynamics 

of the working day ranged from 5.6 to 180 lux, the coefficient of natural light was 

0.19±0.09 - 0.45±0.1%, i.e. there was not enough light at the working places. 

The labor process of the workers in the papillary plant is characterized by 

limited general mobility, the monotony of work operations (cutting cocoons to 

release pupae, separating pupae by floor, working with butterflies), forced, 

uncomfortable working posture. Production operations are performed when working 

with pupae. More than 25% of working time is performed in a forced working 

posture (squatting, kneeling), when mating and separating butterflies more than 80% 



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5848882 

10 

of working time is performed standing, accompanied by the same type of hand 

movements. 

Conditions of work of women working in the silkworm industry refer to the 3rd 

class of the 3rd degree of harmfulness. 

The research was carried out to study the dynamics of indexes of the functional 

state of the cardiovascular system. Practically healthy women workers of  Navoi 

silkworm plant., aged 19 to 58 with 1 to 33 years of work experience, were examined. 

Sixty man-days of working observations were carried out.  

The materials of the researches show that the women workers with 1-10 years 

of work experience have a reliable reduction of heart rate and increase of both 

systolic and diastolic pressure in the dynamics of work. The heart rate slows down 

from 82.2±0.9 to 77.6±0.7 bpm. (p<0.05), systolic blood pressure increases from 

134.8±1.3 to 141.0±1.9 mm Hg. (p<0.05), diastolic pressure increased from 82.0±2.9 

to 93.0±1.3 mm Hg. (p <0,05). Apparently, such a reaction is connected with the 

complex influence of unfavorable production factors in combination with the 

character of the work performed: intensive monotonous work. This was accompanied 

by an unfavorable tendency of hemodynamic indexes changes: pulse pressure 

reduced from 52,0±1,2 to 48,0±0,9 mm Hg (p<0,05). (p <0.05), increase of mean 

dynamic pressure from 99.3±2.1 to 109.0±1.3 mm Hg (p <0.05). (p <0,05). In 

addition, there was a decrease in systolic and cardiac minute volumes from 45.6±1.6 

to 37.0±1.1 mL (p<0.01) and from 3.7±2.4 to 2.8±2.0 L (p<0.05), respectively, from 

beginning to end of work. The hypertensive orientation of changes in cardiovascular 

system indices is confirmed by the reliable increase of peripheral resistance in 

capillaries in the dynamics of work (p<0,05). 

Female workers with 11 to 20 years of work experience also show significant 

hypertensive changes in the maximum, minimum and mean-dynamic blood pressure. 

Moreover, the severity of changes in the indices increases with the length of service. 

Thus if at the work experience up to 10 years the maximal arterial pressure in the 

dynamics of work increased by 4,5% from the background to the operational level, 

then at the work experience up to 20 years this index increased by 7,5%. The 

minimum arterial pressure increased respectively by 13,4 and 14,5%, and mean 

dynamic pressure - by 9,7 and 11,3%. Consequently, the severity of adverse shifts of 

cardiovascular system indices increased with the increase of work experience. This is 

confirmed by hemodynamic indexes of women with more than 20 years of work 

experience. The maximum arterial pressure in this group of examinees increases in 

the dynamics of work already by 8,6% from the background level, other parameters 

change the same way as in women with up to 20 years of work experience. 



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5848882 

11 

The analysis of the obtained data shows that the labor process of the female 

papillomaniacs causes the development of unfavorable changes of hemodynamic 

indices in the dynamics of work, which indicates the weakening of functional 

reserves of the cardiovascular system [9].  

To substantiate the dependence of changes in indicators in the dynamics of the 

shift on the levels of adverse production factors, a mathematical analysis of the 

dynamics of changes with the calculation of correlation, determination and elasticity 

coefficients was performed. The regularity of the dependence of changes in the 

indices on the levels of factors of working conditions has been established. A high 

correlation dependence on both air temperature (r -0.93-1.0) and relative air humidity 

(r -0.62-0.91) has been established for all the changes of cardiovascular system 

indices. 

The regularity of dependence of the dynamics of pulse rate, minimum, mean-

dynamic blood pressure, systolic and minute volumes of the heart on microclimatic 

conditions has been proved. 

It has been found out that the temperature factor has the most negative 

influence on the functional state of the cardiovascular system (the determination 

coefficient is 96.1% on average by all hemodynamic indices, the elasticity coefficient 

is 0.065-0.2%).  

The method of predicting pre-pathological conditions was developed, which 

allowed substantiating measures to reduce the adverse effects of production factors 

on the body of workers. 

Conclusions: 

1. At women working at Navoi silkworm Plant in dynamics of the working 

day, there are observed changes of hemodynamic indexes testifying about 

compensatory tension of processes of regulation of functional condition of the 

cardiovascular system, manifested in pulse increase and increase of arterial pressure, 

and also in the tendency to decrease of systolic blood volume that testifies to some 

weakening of functional reserves of the cardiovascular system. 

2. Expression of changes in cardiovascular system indexes increases with 

working experience.  

3. Calculation of correlation, determination and elasticity indexes allows to 

prognose physiological shifts and prepathological conditions and to substantiate 

measures on the decrease of the unfavorable influence of production factors on the 

functional condition of different systems of the organism. 

  



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5848882 

12 

 

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