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ART of MEDICINE

 International Medical Scientific Journal

Volume 1, Issue 1, May   2021



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International Medical Scientific Journal

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Founder and Publisher Pascual Izquierdo-Egea
Published science may 2021 year. Issued Quarterly.
Internet address: http://artofmedicineimsj.us
E-mail: info@artofmedicineimsj.us
11931 Barlow Pl  Philadelphia, PA 19116, USA +1 (929) 266-0862

Art of Medicine
 International Medical Scientific journal

CHIEF EDITOR

Dr. Pascual Izquierdo-Egea

EDITORIAL BOARD

Prof. Dr. Francesco Albano

Dr. Catherine J. Andersen

Prof. Dr. Sandro Ardizzone

Dr. Dmitriy Atochin

Prof. Dr. Antonio Aversa

Prof. Dr. Tamam Bakchoul

Prof. Dr. Pierre-Gregoire Guinot

Prof. Dr. Rainer Haak

Prof. Henner Hanssen



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CONTENT

Tursunova L. D., Jabbarov O. O.
APPLICATION OF SAKABUTRIL/VALSARTAN IN PATIENTS WITH CHRONIC
KIDNEY DISEASE WITH TYPE 2 DIABETES MELLITUS...............................5

L.S. Khamraeva., D.U. Narzullaeva
FEATURES OF CALCULATING THE OPTICAL POWER OF AN
INTRAOCULAR LENS IN CHILDREN WITH CONGENITAL CATARACTS
AT THE RISK OF DEVELOPING PSEUDOMYOPIC MYOPIA.....................10

Kasimova M. S., Iminova M. M., Ashurov O. M.
OPHTHALMOLOGIC COMPLICATIONS IN THE STRUCTURE OF THE
CLINICAL FEATURES OF NOVEL CORONAVIRUS INFECTION
(COVID-19)......................................................................................................14

Fattayeva D.R., Rizayev J.A., Rakhimova D.A.
IMPROVEMENT OF METHODS FOR CORRECTION OF CLINICAL AND
IMMUNOLOGICAL DISORDERS IN COMORBID STATE OF CHRONIC
GAYMORITIS AFTER COVID-19....................................................................17

Polatova D.Sh., Abdukarimov Kh.G., Davletov R.R., Savkin A.V., Sultanov B.B
FEATURES OF IMMUNOBIOLOGICAL HETEROGENEITY IN PATIENTS
WITH OSTEOSARCOMA.................................................................................25



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IMPROVEMENT OF METHODS FOR CORRECTION OF CLINICAL AND
IMMUNOLOGICAL DISORDERS IN COMORBID STATE OF CHRONIC
GAYMORITIS AFTER COVID-19

Fattayeva D.R.
Tashkent State Dentistry Institute, Republic of Uzbekistan, Tashkent

Rizayev J.A.
Samarkand State Medical Institute, Republic of Uzbekistan, Samarkand

Rakhimova D.A.
The Republican Specialized Scientific And Practical Medical Center For

Therapy And Medical Rehabilitation.

Abstarct.Each body has its own defenses, which help to neutralize and destroy
various microorganisms that can cause disease.

However, sometimes these defenses are weakened for whatever reason, and cannot
cope with the infection penetrated. The question arises: how to boost immunity? How to
prevent the occurrence of dangerous diseases? What can help strengthen the body? This
article will help you understand these and other issues.

Keywords: immunity, kinds of immunity, gaimor sinus, herbal preparations

The frequency of odontogenic inflammation of the maxillary sinus is ambiguous.
Odontogenic maxillary sinusitis accounts for 3 to 7% of the total number of all
stomatological diseases, patients with odontogenic maxillary sinusitis account for about
25.8% among patients with inflammatory processes of the maxillary sinus and about
7.6% of all patients with maxillofacial diseases. [1-4]. According to AA Timofeev [5],
odontogenic sinusitis occurs in 21.3% of cases, and rhinodontogenic - in 3.1% of the
total number of purulent - inflammatory processes in the maxillofacial region, and from
all cases of sinusitis, 87% and 13%, respectively . Despite the emergence of new,
original and, indeed, effective methods of diagnosis and treatment of paranasal sinusitis,
their number is growing every year. According to the data of domestic and foreign
authors, the incidence of chronic sinusitis over the past 10 years has increased by more
than 2 times, and the proportion of patients hospitalized in ENT hospitals is increasing
annually by 1.5 - 2% and has no tendency to decrease. Of particular interest in this plan
are the combined diseases of the periodontal, maxillary sinus and bronchi. According to
some authors, a combination of chronic nonspecific lung diseases and chronic sinusitis
is noted in 17.7-28.0% of cases (1,6,12).  Studies have revealed a relationship  between
foci of chronic odontogenic infection and an increased risk of developing chronic
obstructive bronchitis and bronchial asthma. The foci of infection in the tissues of the
periodont also serve as a reservoir for the colonization of respiratory pathogens that
cause the development of infectious pneumonia, and the destruction of the periodontal
inflammation-destructive nature can sensitize the course of the bronchial organisms and
thus with it (3,4,13).

In turn, a chronic process in the bronchi, reducing the general immunological reactivity
of the body, can contribute to the progression of inflammatory diseases of the tissues of
the parodontium. It is suggested that the quantitative and qualitative composition of the
microbial landscape of the oral cavity is determined by the reactivity of the organism
(5,7,9).  In addition, chronic obstructive pulmonary diseases are accompanied by the
development of systemic hypoxia, including periodontal tissues, which, according to a



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number of researchers, is also a factor that aggravates the course of sinusitis (10, 14).
Against the background of the existing metabolic disorders, the oxygen deficiency in the
tissues of the periodont further inhibits the regenerative and reparative processes in all
its structural components and the mucous membrane.

The importance of the combined pathology of the periodontal and bronchi is determined
not only by the prevalence and severity of the disease, the negative effect on the body
as a whole, but also by the low effectiveness of the treatment. In the domestic and foreign
literature, there are practically no scientifically substantiated data on the possibilities of
an integrated approach to systemic methods of treating sinusitis combined with chronic
obstructive pulmonary disease (COPD), which is due to the functional and industrial
separation of dentists with other specialties. At the same time, one of the main directions
of therapeutic measures is the correction of the immunological imbalance detected in
such patients (2,15).

At the present time, the study of the clinical and immunological features of the course
of sinusitis combined with chronic obstructive pulmonary disease and the improvement
of the methods of complex therapy is an urgent problem of stomatology.

In our age of new technologies, every year the burden of unfavorable environmental
factors on our health is increasing. First of all, the mechanisms of the protective
reactions of our body are exposed to the negative influence. [2,17]. Immunity is the
ability of human and animal organisms to specifically react to the presence of some
substance, usually foreign, in it. This reaction to foreign substances ensures the body's
resistance, and therefore is extremely important for its survival. The reaction is based on
the synthesis of special proteins, so-called antibodies, capable of entering into combination
with foreign substances - antigens. The science that studies the mechanisms of immunity
is called immunology. [1,3]. The main elements of the body's immune system are white
blood cells - lymphocytes, existing in two forms: T-lymphocytes and B-lymphocytes.

The antibodies produced by B-cells and entering the blood and other body fluids are
referred to as factors of humoral immunity (from Lat. Humor - liquid). The protection
of the organism, carried out with the help of T-cells, is called cellular immunity, since
it is based on the interaction of individual cells with antigens. T cells not only activate
other cells by releasing lymphokines, but also attack antigens with the help of structures
containing antibodies on the cell surface.

Damage or inadequacy of this protective system can manifest itself in the form of
allergic reactions to substances that are usually harmless to the body [3,22]. Congenital
and acquired: congenital or hereditary. We are born with you with a certain set of
antibodies, genetically laid down in us. For example, American Indians are much less
susceptible to syphilis than Europeans. Acquired or adaptive. It is formed under the
influence of the external environment. That is, any infection leads to the development
of antibodies in the body, which immediately become involved in the struggle when
they meet again with this pathogen. Vaccination is a particular case of acquired immunity.

Active and passive: active - the production of antibodies as a result of external
influences. Post-infectious and post-vaccination immunity is always active. Passive - the
introduction of antibodies from the outside. For example, serum containing donor
antibodies. The composition of mother's milk includes antibodies that protect the baby,
and this is also a passive immunity.

Specific and nonspecific: nonspecific - a complex of mechanisms aimed at protecting
against any external intrusion. Example: saliva and tears contain antibacterial substances;
interferon is present in the blood, which fights any viral particles that enter the body.
Specific - antibodies against a very specific pathogen, some for influenza, others for
plague, others for whooping cough, etc. [4,6,23]. It is a great misconception that the



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immune system fights only against microorganisms or viruses. It also protects us from
cancer cells, which are defined as "alien" and are eliminated by specific and nonspecific
mechanisms. Therefore, one of the theories of the origin of cancer associates this disease
with a malfunction in the immune system. There are several factors that negatively affect
the immune system. Stress and negative emotions (fear, anger, jealousy, anxiety,
disappointment, regret, concern), generated by the unsuccessful attempts of many
people to meet the requirements of life, cause disastrous experiences. They give rise not
only to neuroses, but also to many other diseases. Stress and negative emotions lead to
an increase in blood levels of cortisol, a hormone that is a poison for immune cells
[12,15]. The lack of sleep has the same effect on the immune blood cells. With a
reduction in the time of sleep, the number of cells that defeat a viral infection is reduced
by a third [7]. Unfavorable ecology. The human environment is ubiquitously contaminated
with various carcinogens (radioactive radiation, chemical and others). An unfavorable
environment, constantly affecting the body, even in permissible concentrations, leads to
"overwork" of internal organs and systems, including a decrease in immunity. So, the
number of people suffering from various types of allergies at the beginning of the
century was counted in units, and now more than 50% of the population suffer from it.
Bad habits further worsen the air environment. Not only active, but also passive smoking
contributes to the spread of infection. Sun rays. Ultraviolet rays, if exposed for too long,
destroy the skin's immune cells. Physical stress (work, sports), leading to overwork,
reduces immunity. It is no coincidence that all peoples have at least one day of rest per
week. A, if a person, in addition to five working days, still works on weekends (for
example, at work), then the overload is inevitable. Temperature load (overcooling,
overheating), leading to overwork, also reduces immunity [4]. Nutrition is, perhaps, the
most important factor affecting the immune system. With a lack of food, it ceases to
fulfill its protective function, the body easily, without a fight, becomes a victim of various
infections. This circumstance should be borne in mind by those who often use a diet with
limited calorie content. The defenders of our health - immune cells - need vitamins A,
C, E and B, as well as trace elements such as selenium, zinc, iron. Their deficiency
slows down the division of these cells, reduces their activity. All the necessary substances
are contained in ordinary food. Self-disposal.

- Alcohol with frequent use suppresses the activity of T-lymphocytes - cells that play
an important role in the destruction of pathogens.

- Some medications (antibiotics, cortisone and pain relieversa) reduce the mobility
of immune cells, their aggressiveness towards pathogens, and the ability to produce
antibodies [6]. Signs of weakened immunity The line between reduced and normal
immune function is very thin and it is impossible to determine it independently. Therefore,
you should contact a doctor, an immunologist, an allergist, who will assign an
immunological laboratory study to clarify the presence of immunodeficiency. Indirect
signs of its decline can be:

- frequent colds, viral infections more than 5 times a year (this is normal for preschoolers,
not for older children and adults, see the difference between influenza and SARS and
how to treat a cold in a child).

- increased fatigue, general weakness, headaches, blue under the eyes, pallor of the
skin. However, such symptoms can be present in case of blood diseases, therefore, in
case of such symptoms, one should consult a doctor.

- drowsiness, insomnia (see how to fall asleep quickly).
- enlargement of the spleen, painless enlargement of the cervical and axillary lymph

nodes.
- brittle nails, dull split hair (see causes of hair loss)



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- dryness and flaking of the skin (see treatment of cracked hands).
- Allergy - a sign of a failure in immunity (food allergies, allergies to the sun, cold

allergies, allergic cough, allergic rhinitis).
- intestinal dysbiosis, which can be manifested by decreased appetite, flatulence,

impaired stool, weight loss [7,18].
Despite the fact that today in every pharmacy you can find a lot of drugs to increase

immunity,  natural medicine recipes and herbal medicines are still very popular. Moreover,
many scientific laboratories, which are engaged in the search for substances that
strengthen the immune system, find inspiration in natural resources, isolating and
studying the active components of plants. Physiologically active substances inside plants,
due to their complex, delicately balanced composition by nature itself, cause complex
changes in the function of the immune system. These changes, including selective
stimulation of the lagging links of the immunological response and the same selective
suppression of overly active links, are called immunomodulation. Accordingly, the
plants used for this purpose are called immunomodulators. Many known plants belong
to the group of immunomodulators. Significant advances in the treatment of HAP in
recent years are associated with the use of phytopreparations and alternative therapy,
which significantly improve the survival rate and life prognosis of patients with cor
pulmonale. (3)

However, not all the effects of glycyrrhizic acid have been sufficiently studied. The
plant world is rich in medicinal plants, among them you can distinguish naked licorice.
Licorice naked has been used for a long time for diseases of the bronchocellular system
in the practice of oriental medicine. Avicenna very often mentioned licorice in his
"Canons" as a means of "facilitating the work of the bronchi and lungs, removing all kinds
of fluids." [7].

Glycyrrhizic acid (HA) from the composition of naked licorice can have several
beneficial effects at once. First of all, of course, we are talking about the presence of
anti-inflammatory effects. In addition, drugs containing this substance have antiviral,
antipruritic and immunostimulating effects. Antiviral action is carried out mainly against
the following pathogens: human papilloma virus and some others [2,6,8]. The antiviral
effect is based on the ability of glycyrrhizic acid to interrupt the reactions of viral DNA
synthesis at various stages of this process. As a result, the assembly processes of viral
particles cannot reach the stage of complete completion, and this means that the
causative agent of the disease will be deprived of the opportunity to multiply. In addition,
glycyrrhizic acid blocks the processes of interaction between the virus and the target
cell, which greatly complicates the penetration of the pathogen, where it can have its
harmful effect. In addition to the above, it should be noted the ability of glycyrrhizic
acid to enhance the reactions responsible for the processes of biosynthesis of interferons.
These substances significantly reduce the susceptibility of healthy cells to viral particles,
which inhibits the spread of pathology. All of the above effects are manifested even with
the use of drugs in non-toxic dosages, which means that the risk of developing unwanted
consequences of antiviral therapy is minimized [1,2].

Glycyrrhizic acid preparations are highly active against the pathogens mentioned
above. Unlike many other representatives of the group of antiviral drugs, addiction
rarely develops to such drugs, even despite constant mutations of the causative agents
of the disease. Glycyrrhizic acid is a stimulant of nonspecific immunity. When exposed to
this substance phagocytic reactions are activated, which are responsible for the capture
and destruction of foreign agents [1,10].

On the basis of the extract of licorice - glycyrrhizic acid, a number of expectorants
have been created. However, due to the emergence of powerful expectorants, its use has



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receded into the background.
Celandine Big, elecampane tall, field clover (red), representatives of the stonecrop

family [2]. Plants, called adaptogens, have an immunomodulatory effect. This category
includes many representatives of the Araliev family (Eleutherococcus, Aralia), Chinese
magnolia vine, Rhodiola rosea, licorice and some others. With weakened immunity,
stimulation is required. For this purpose, use means -immunostimulants, for example,
aloe-agave [3].

With the advent of biologically active food additives on the Russian market,
immunomodulatory plants have become known that grow in South America, Southeast
Asia and other regions of the Earth. Examples: gotu kola (Gotu cola), cat's claw -
wiltsazora (Uncaria tormentosa). Immunomodulating plants can only increase humoral
immunity [24].

Preparations for enhancing immunity
Medicines that have a stimulating effect on immunity can be classified both by origin

and by the mechanism of influence.
Herbal preparations
o Echinacea
This is the name of a whole clan from the Astrov family. This genus contains 10

species, of which Echinacea Purpurea is the most popular as a medicinal raw material.
For medicinal purposes, all parts of the plant are used: stems, leaves, roots, flower
baskets. Echinacea contains a large amount of vitamins and essential oils, has a direct
antimicrobial and antiviral effect, and also stimulates cellular immunity (increases the
number of leukocytes in the blood). The most popular drug containing echinacea is
immunal [12].

Echinacea purpurea is used: - for infectious and septic diseases, outwardly - for
carbuncles, abscesses, infected wounds, burns of I-III degree (as an anesthetic) and
severe bedsores;

- Echinacea preparations are used with a prophylactic purpose at the first signs of a
cold, with prolonged use of antibiotics, recovery of persons who have undergone
exposure to radiation or living in areas unfavorable for radiation levels; - the anti-
inflammatory effect of biologically active substances of echinacea is combined with its
immunomodulatory properties and is used in pulmonary practice: regular prophylactic
intake for 40-50 days allows you to almost 2 times reduce the likelihood of respiratory
tract infection, and in case of infection, the disease occurs in a milder form;

- Echinacea preparations are used in allergological practice, which is determined by
their immunomodulatory, anti-inflammatory and antioxidant properties;

- Echinacea preparations have a therapeutic effect in various pathological conditions
by increasing the natural protective forces of the body.

- As a result of pharmacological studies, the stimulating effect of echinacea on the
immune system has been shown. This effect is manifested not only in adults, but also in
children with an unsettled immune system, as well as in elderly people, in whom the
functions of this system are reduced due to general aging of the body [29].

- Eleutherococcus is a genus of thorny shrubs and trees from the Araliev family,
which includes 30 species. Its roots and rhizomes are considered medicinal raw materials.
It is used as an extract. Contains a mass of useful substances with anti-stress action. It also
contains caffeine, so it invigorates and increases performance. It was included in the
composition of the drink under the name "Baikal", which was also called "Soviet Coca-
Cola" [13].

- Ginseng - Whole volumes have been written about its beneficial properties, so I
will not repeat myself, I will only point out that the composition of this root is similar



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to the composition of Eleutherococcus, therefore, almost everything that is written on
ginseng is fair for Eleutherococcus. And do not forget about caffeine, which can cause
an overdose, addiction and can be dangerous in case of hypertension and heart disease
[7,14].

- Chinese schisandra is a perennial flowering plant. Fruits are used for food, tea can
be brewed from the leaves. Contains a huge amount of Vitamin C, and also has a powerful
psychostimulating effect, increases performance and resistance to stress, in case of an
overdose, causes insomnia. Also, as with ginseng, it is necessary to take "hypertensive
patients" and "cores" with caution.

- Bacterial preparations - a group of drugs containing components of the bacterial
cell. Bacterial proteins entering the body do not cause a disease, but an immune response
to a given microorganism, therefore, when it encounters a real microbe, the immune
system will already be "armed" with antibodies. The action of drugs from this group is
similar to vaccines [6,25].

- Ribomunil, imudon, irs-19, lycopid, etc. - contains the components of bacteria
most common in infections of the upper respiratory tract and ENT organs.

- Uro-vax - lysate of Escherichia coli bacteria, is used for chronic urinary tract
infections caused by this microbe.

Interferon preparations are drugs with antiviral activity, divided into two large subgroups.
Human interferon. In fact, there are about 20 interferons in our body, divided into 3
subgroups (alpha, beta and gamma). Pharmaceutical companies can produce them both
separately and in the form of mixed mixtures: laferon,  viferon,  velferon,  gripferon,  etc.
Produced from donated blood or using genetic engineering. Stimulants of endogenous
interferon production - a group of drugs in the fight against viral infections, especially
influenza: anaferon, arbidol, amiksin, kagocel, etc. [5].

Nucleic acid preparations are stimulators of cellular and, to a lesser extent, humoral
immunity, the mechanism of action of which has not been fully understood. They are
mainly used for bacterial infections (including tuberculosis), to enhance the effectiveness
of vaccines: sodium nucleinate, derinat. Also, these drugs have a pronounced wound
healing effect, which makes them very useful for purulent wounds and extensive burns.
Some drugs of this group are used as stimulants of interferon production in viral
infections - ridostin [7].

Thymus preparations or other name immunoregulatory peptides: thymalin, thymosin,
thymactide, thymogen, etc. The very old group of immunomodulators, known since the
1970s. They are extracts of the thymus gland of animals. They stimulate individual links
of immunity, but are effective only in immunodeficiency states caused mainly by
chronic infections: tuberculosis, trophic ulcers, etc. [22, 30].

Biogenic stimulants. This is a group of immunostimulants, the source for which are
animals or plant tissues: aloe extract, Actovegin, FiBS, humisol, biosed. The mechanism
of action has not been fully understood, therefore, medical literature, which has not
been abused by pharmaceutical cartels, is full of skepticism about the effectiveness of
this group of drugs [8].

A fairly new drug Polyoxidonium (1997), which is now actively used, in addition to
immunostimulating, antioxidant, detoxifying and membrane stabilizing effects, has the
properties of a hepatoprotector (review of tablets for the liver) - hepatoprotectors. To
increase its bioavailability, a drug has been created - longidase (a combination of lidase
and polyoxidonium) [9].

Vitamins. They normalize metabolic processes in the body, including restoring the
functioning of the immune system. But it is best to use natural products containing
vitamins - fruits, vegetables, cereals, nuts, sea fish, etc. vitamins). Moreover, studies by



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doctors at the University of Washington led to terrible results. For many years they have
studied the evolution of the state of health of 78,000 people 50-76 years old and came
to a startling conclusion. The increased use of vitamins C and E at the same time is
extremely dangerous, since it leads to a significant increase in the risk of developing lung
cancer. Finnish scientists have come to the conclusion that the combination of E and C
vitamins provokes the onset of tuberculosis. You should be aware that there are many
multivitamin complexes on the Russian market, the content of vitamin E in which is
very high, moreover, often vitamin complexes cause allergic reactions. Therefore, their
use should be treated with caution, as with any drugs, drink vitamins only in a strict
course of indications and appointment of a doctor, give preference to 1-2 component
preparations (it is better to make sure that there is a lack of one or another vitamins in
blood) [4.25]. Transfer-factor. In the early 50s of the last century, special proteins were
discovered that transmit information from one immune cell to another, providing a link
between cellular and humoral immunity. The combination of these proteins was called
the transfer factor. In the 80s of the 20th century, Life Research was able to develop
a technology for extracting the transfer factor from cow colostrum and chicken yolks. It
was found that the transfer factors of cows are identical to human ones, as a result of
which the idea was born to stimulate the production of antibodies in our body with their
help. For more than 30 years Life Research has been selling the transfer factor as a BAA
all over the world. The manufacturer claims that their product has no contraindications
and side effects, so it can be used even for pregnant and nursing infants. Doubts are
raised by the fact that for all these years Life Research has not been able to register the
transfer factor as a drug. It is believed that they do not have sufficiently convincing data
on the clinical efficacy of the manufactured product [17]. Medicines and preparations.
'Immunal' is produced in Slovenia; (Immunal) - 100 ml of a 20% solution of ethanol
contains 80 ml of juice of flowering echinacea purpurea in 50 ml bottles. It is used to
increase nonspecific immunity in case of recurrent colds, to prevent colds and flu, to
prevent immunodeficiency with prolonged antibiotic therapy. Drink Immun-Guard is a
source of sambunigrin glycoside,  echinacoside and vitamin C. It has anti pyretic,
diaphoretic, diuretic, anti-inflammatory, expectorant, and sedative effect. It is used for
colds, flu, bronchitis, pneumonia, dry cough, edema [7].

Our domestic medicine produces a natural immunostimulant called ImmuHelp.
Immuhelp has a complex effect on the immune system and has an original combination
of herbal components. One capsule of Immuhelp contains: golden root, wild rose,
valerian, marsh air, scarlet, elecampane, anise, carnation, mint, oregano. The drug is
intended to maintain the function of the immune system and restore normal physiological
functions of the body in asthenic conditions and also after prolonged bed rest. As an
immunostimulating agent, Immuhelp is prescribed: Children 1 capsule 3 times a day 5-
10 minutes before meals, adults 1-2 capsules 3 times a day 5-10 minutes before meals.
The course of treatment is 15 days.

In scientific research [3,4,5] examples are given:
the prescription of antibiotics is inadequate: the use of two or  more antibiotics in the

absence of a pronounced clinic of inflammation. Surgical treatment was carried out in
70% of cases: plastic fistula (7.7%); radical sinusitis (83%); cystohaymorotomy (8.2%).
Among the operated patients with acute sinusitis made up 1.8% of all examined and
about 44% in this group. With ACHOG, 31% of all patients and 57% with a diagnosis
of ACHD were operated on. Conservative treatment was carried out in 35 (2.4%)
patients with chronic odontogenic sinusitis, 12 (0.8%) patients with a foreign body in
the maxillary sinus. Thus, the problem of prevention, diagnosis (including differential)
and treatment of odontogenic sinusitis is an urgent task of dentistry. Among the causes of



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the development of the disease, a significant part is made up of pathological processes,
the development of which was facilitated by inadequate medical tactics in the treatment
of chronic inflammatory processes in the upper jaw molars.

References.
1.Aäî A.Ä. "Îáùaÿ aëëåðãîëîãèÿ. Ðóêîâîäñòâî äëÿ âða÷åé".- Ìîñêâa, "Ìåäèöèía",

2008.
2.Áaðûøíèêîâ A.Þ. "Èììóíîëîãè÷åñêèå ïðîáëåìû aïîïòîça". - Ìîñêâa,

Ýäèòîðèaë ÓÐÑÑ, 2002.
3.Áîãàòîâ À. È. Àíàëèç îøèáîê è îñëîæíåíèé ïðè õèðóðãè÷åñêîì ëå÷åíèè

áîëüíûõ ñ îäîíòîãåííûìè âåðõíå÷åëþñòíûìè ñèíóñèòàìè // Àêòóàëüíûå âîïðîñû
ñîâðåìåííîé ñòîìàòîëîãèè. - Ñàìàðà, 2000. - ñ.102-103.

4.Âèøíÿêîâ Â. Â. Àíàòîìè÷åñêèå âàðèàíòû ñòðîåíèÿ ïîëîñòè íîñà è
îêîëîíîñîâûõ ïàçóõ ïðè êîìïüþòåðíîé òîìîãðàôèè / Â. Â. Âèøíÿêîâ // Âåñòí.
îòîðèíîëàðèíãîëîãèè. - 2004. - ¹1. - Ñ. 65-67.

5.Åìåëüÿíåíêî Ë. Ì. Ýôôåêòèâíîñòü ëå÷åíèÿ ãíîéíîãî ãàéìîðèòà ëàçåðîôîðåçîì
ñ èçîòèîðáàìèíîì / Ë. Ì. Åìåëüÿíåíêî, Ñ. Ñ. Öåëóéêî, Î. È. Êîíîïëåâ. - Òð. 16
ñúåçäà îòîëàðèíãîëîãîâ ÐÔ. - Ñ.-Ïåòåðáóðã, 2001. - ñ.56-57.

6.Êëaóñ Äæ. "Ëèìôîöèòû. Ìåòîäû". - Ìîñêâa, Ìèð, 2000.
7.Êîëëèíç Ó.Ï. "Íîâûå ìåòîäû èììóíîaíaëèça".  - Ìîñêâa, Ìèð, 1991.
8.Ëåáåäåâ Ê.A. "Èììóíîëîãèÿ â êëèíè÷åñêîé ïðaêòèêå". - 2006.
9.Ëåôêîâèòñ È. "Ìåòîäû èññëåäîâaíèÿ â èììóíîëîãèè". - Ìîñêâa, Ìèð, 2001.
10.Ëîïàòèí À. Ñ. Õèðóðãè÷åñêîå ëå÷åíèå îäîíòîãåííîãî âåðõíå÷åëþñòíîãî

ñèíóñèòà / À. Ñ. Ëîïàòèí, Ñ. Ï. Ñûñîëÿòèí, Ï. Ã. Ñûñîëÿòèí // Ðîñ.ñòîìàòîë.æóðíàë,
2001. - ¹3. - ñ.24-28.

11.Ìåäóíèöûí Í.Â. "Îñíîâû èììóíîïðîôèëaêòèêè è èììóíîòåðaïèè
èíôåêöèîííûõ áîëåçíåé". - Ìîñêâa, ÃÝÎÒAÐ-Ìåäèa, 2005.

12.Ìåøêîâa Ð.ß "Ðóêîâîäñòâî ïî èììóíîïðîôèëaêòèêå äëÿ âða÷åé".- Ñìîëåíñê,
1998.

13.Ìèíååâa Í.Â. "Ãðóïïû êðîâè ÷åëîâåêa. Îñíîâû èììóíîãåìaòîëîãèè". - Ñaíêò-
Ïåòåðáóðã, 2004.

14.Íañîíîâ Å. Ë. "Aíòèôîñôîëèïèäíûé ñèíäðîì". - Ìîñêâa, Ëèòòåðða, 2004.
15.Îäîíòîãåííûå ãàéìîðèòû / À. À. Òèìîôååâ, Ã. Ï. Áåðíàäñêàÿ, Ë. Ô. Êîð÷àê,

Ñ.Ï.Êîëîìèåö - Êèåâ: ×åðâîíà ðóòà-Òóðñ. - 2002. - ñ.48-50
16.Ïîêðîâñêèé Â.Â. "Êëèíè÷åñêaÿ äèaãíîñòèêa è ëå÷åíèå ÂÈ×-èíôåêöèè". -

Ìîñêâa, ÃÎÓ ÂÓÍÌÖ ÌÇ ÐÔ, 2001.
17.Ñèïêèí À. Ì. Äèàãíîñòèêà, ëå÷åíèå è ðåàáèëèòàöèÿ áîëüíûõ îäîíòîãåííûìè

âåðõíå÷åëþñòíûìè ñèíóñèòàìè, ñ ïðèìåíåíèåì ýíäîñêîïè÷åñêîé òåõíèêè:
àâòîðåô.äèñ.íà çäîáóòòÿ íàóê.ñòóïåíÿ ê.ìåä.í.: ñïåö.14.00.21-ñòîìàòîëîãèÿ / À.
Ì. Ñèïêèí. - Ìîñêâà, 2005. - 20 ñ.

18.Øàðãîðîäñêèé À. Ã. Âîñïàëèòåëüíûå çàáîëåâàíèÿ òêàíåé ÷åëþñòíî-ëèöåâîé
îáëàñòè / À. Ã. Øàðãîðîäñêèé. - Ì., 2001. - ñ.86-98.

19. Øóëüìàí Ô. È. Èíîðîäíûå òåëà âåðõíå÷åëþñòíûõ ïàçóõ. Òàêòèêà âðà÷à / Â.
À. Êîçëîâ, Ô. È. Øóëüìàí. // Òðóäû VII Âñåðîññèéñêîãî ñúåçäà ñòîìàòîëîãîâ, 10
- 13 ñåíòÿáðÿ 2001 ã. - Ìîñêâà. - 2001. - Ñ.98-100.


