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International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5843266 

1 

  



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5843266 

2 

 

 
 

 

 

Art of Medicine International Medical Scientific journal 

 

Founder and Publisher Pascual Izquierdo-Egea 

Published science may 2021 year. Issued Quarterly. 

Internet address: http://artofmedicineimsj.us 

E-mail: info@artofmedicineimsj.us 

11931 Barlow Pl Philadelphia, PA 19116, USA +1 (929) 266-0862 

 

 
  



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5843266 

3 

 

View of the quality of the life in ankylosing Spondiloarthritis  

Pulatova Shakhnoza Bakhtiyarovna 

Tashkent Medical Academy  

Abstract: Ankylosing spondylitis (AS) is a chronic systemic inflammation of the 

joints, mainly of the spine, with limitation of its mobility due to ankylosis of the 

apophysal (synovial intervertebral) joints, the formation of syndesmophytes (bridges 

between the vertebrae) and calcification of the spinal ligaments. The study of the 

quality of life of patients with AS is especially relevant, since the main features of 

rheumatic diseases are a chronic progressive course leading to dysfunction of the 

musculoskeletal system and disability. All these factors give them the character of 

social diseases, which reduce the biological, physiological and psychological activity 

of members of society. 

Keywords: spondyloarthritis; ankylosing spondylitis; the quality of life. 

The quality of life is the most important social category that characterizes the 

structure of human needs and the possibility of meeting them [1]. With regard to 

medicine, the quality of life is an integral characteristic of the physical, 

psychological, social and emotional state of a patient, assessed based on his 

subjective perception. According to the WHO definition, the quality of life is the 

perception by individuals of their position in life in the context of the culture and the 

system of values in which they live, in accordance with goals, expectations, norms 

and concerns [2]. The quality of life is determined by the physical, social and 

emotional factors of a person's life that are important to him and affect him. 

The quality of life is the degree of a person's comfort both within himself and 

within his society. The quality of life of patients with AS is primarily due to the 

degree of functional impairment, which is associated with the nature and level of 

spinal lesions [3]. 

AS is characterized by late diagnosis, which, according to literature data, is 5-

10 years late, which leads to early disability. According to a number of authors, from 



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

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34 to 81% of patients are partially or completely disabled [4]. Components of quality 

of life Health-related quality of life is based on 3 main components: physical sphere: 

rest and sleep; feeling of physical pain and discomfort; vitality, energy and fatigue; 

the ability to carry out daily activities; ability to work - study, work, etc .; mobility; 

dependence on drugs in treatment. 

Social sphere: personal relationships; practical social support; sexual activity, 

financial resources; medical and social assistance; opportunities to acquire new 

information and skills; opportunities for good rest and entertainment; climate; 

transport. 

Psychological sphere: positive and negative emotions; thinking, learning, 

memory and concentration; self-esteem; appearance, religious beliefs [5]. The 

physical sphere in AS is characterized by pronounced medical and socio-economic 

consequences. The onset of the disease at a young age, its steady progression with 

ankylosis of the spine and large joints, loss of the ability to carry out important 

activities for the patient and loss of professional independence, significant difficulties 

in performing simple everyday motor skills - all these are severe consequences of the 

disease [6]. 

Pain is the main symptom of this disease along with deformity joints and 

impaired mobility. It is the severity of pain the syndrome has a significant impact on 

the quality of life of patients with joint pathology, and can cause various emotional 

disorders, sleep disorders and pain behavior. Majority AS patients, first of all, expect 

from treatment a decrease in pain syndrome in comparison with other manifestations 

of the disease. Vital activity changes also occur in patients with AS. They become 

less active due to the present pain and stiffness in the joints, they quickly get tired 

when doing everyday activities. Therefore, after the detection of this disease, patients 

have to significantly change their usual way of life. Sometimes you even have to 

change the place of work, profession [7]. 

As the disease progresses, the affected joints become all less mobile up to 

complete ankylosis, which is also essential changes the patient's lifestyle and 



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

10.5281/zenodo.5843266 

5 

significantly affects his emotional and the physical state. AS is quite common all over 

the world. It is characterized by chronic inflammation, which, without appropriate 

treatment, leads a person to disability, a significant reduction in life expectancy and a 

significant deterioration in its quality. AS is among the most expensive in the 

treatment of diseases. In the absence of timely diagnosis and active therapy, the 

patient becomes disabled within the first 5 years from the onset of the disease. This 

disease is of high social importance [8]. 

AS can affect up to half a million Russians. And given that it is mainly young 

active people who suffer from it, that is, the future of the country, the problem is 

acquiring a more general, socio-economic character. As the disease progresses, the 

appearance of a person with AS begins to change: the patient's spine becomes either 

even, devoid of physiological bends, or resembles a question mark due to increased 

cervical lordosis and thoracic kyphosis. Because of this, isolation and self-doubt may 

appear, which in the future can lead to impaired socialization and the development of 

healthy interpersonal relationships [9]. Uncertainty leads to a deterioration in the 

quality of life of patients with AS and significant psychosocial problems 

etiopathogenesis of the disease, frequent inconsistency of clinical manifestations 

diseases of the severity of AS, the need for constant intake of drugs, insufficient 

therapeutic efficacy of the drugs used [10]. In this case, the patient's personality 

changes both as a result of the direct effect of the disease and as a result of the 

patient's psychological experience of his condition, which is reflected in a decrease in 

self-esteem and self-confidence, dissatisfaction with his lifestyle, the development of 

anxiety, hostility, anger and depression. It is the personal aspect of the reaction to the 

disease that underlies the formation of a specific internal picture of the disease, which 

can significantly transform the clinical picture of the disease and have a significant 

negative impact on the effectiveness of therapeutic measures [11]. 

These problems are central to the phenomenon of the so-called "internal picture 

of the disease." A long-term disease can lead to various restructuring of the internal 



Art of Medicine           Volume-2 

International Medical Scientific Journal        Issue-1 

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picture of the disease associated with the characteristics of the course of the disease 

and with complex processes of adaptation and maladjustment [12]. 

Inadequate internal picture of the disease is mediated negatively affects the 

course and outcome of the disease, promotes destructive changes in the patient's 

personality, the development of internal conflicts of various plan, severe neurotic 

disorders, maladaptive types of reactions to illness that aggravate the picture of 

organic suffering, its course and duration, and, as a rule, worsen the behavior of 

patients in relation to ongoing therapy [13]. 

Thus, AS has a significant effect on all spheres of the patient's life, leads to a 

significant decrease in the patient's quality of life, limiting not only the functional, 

but also the psychological component, contributes to the formation of social 

maladjustment [14]. 

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