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International Medical Scientific Journal       Issue-2 

10.5281/zenodo.5533529 

134 

    



Art of Medicine           Volume-1 

International Medical Scientific Journal       Issue-2 

10.5281/zenodo.5533529 

135 

 

Art of Medicine International Medical Scientific journal 

 

Founder and Publisher Pascual Izquierdo-Egea 

Published science may 2021 year. Issued Quarterly. 

Internet address: http://artofmedicineimsj.us 
E-mail: info@artofmedicineimsj.us 

11931 Barlow Pl Philadelphia, PA 19116, USA +1 (929) 266-0862 

 

 
 

  



Art of Medicine           Volume-1 

International Medical Scientific Journal       Issue-2 

10.5281/zenodo.5533529 

136 

Study of the application of magnetotherapy in complex with ganoderma lucidum 

extract on the state of the immunocompetent system in the treatment of patients with 
dual ultra disease with dysbiosis. 

 

Kadirova S.R. Khamrabaeva F.I. 

Center for the Development of Professional Development of Medical Workers of the 
Ministry of Health of the Republic of Uzbekistan  

Abstract  

Purpose of the study: to study and scientifically substantiate the use of 

magnetotherapy in combination with synbiotics in the rehabilitation treatment of 
patients with intestinal dysbiosis. 

Research  methods: 90 patients with colonic dysbiosis, 53 women and  25 men, aged 

18-65 years, were studied. 
Treatment  methods. In accordance with the objectives of the study, all patients 

were divided into groups comparable in terms of the main clinical and physiological 

characteristics. Patients of the first group (30 patients) were treated with magnetic 

therapy (MT) from the "Olymp-1" apparatus.  
The impact was carried out by 4 pairs of inductors - solenoids on the area of 

projection of the organs of the large intestine; exposure parameters: intensity - 30% - 

100%, frequency 10 Hz, magnetic induction value - 5 mT. The procedures were 
carried out daily, lasting 15-20 minutes. The course of treatment is 10-12 procedures. 

Patients of the second group (30 patients) underwent complex treatment: MT 

according to the above method, as well as a synbiotic consisting of an extract of 

Ganoderma Lucidum - 1 capsule 2 times a day with meals for 21 days 
 In the third comparison group (30 patients), the effect of MT from the “Olymp-1” 

apparatus (placebo) was imitated. The course of treatment consisted of 10-12 

procedures. Ganoderma Lucidum extract was included in the treatment complex 
according to the above scheme. 

The results of the studies conducted suggest that the proposed complex treatment 

potentiates and prolongs the analgesic and anti-inflammatory effects, has an 

immunocorrective effect, promotes the growth of saccharolytic microflora, restores 
the dynamic balance of the intestinal microflora and biotope, improves the functional 

state of the intestine, and has a positive effect on the psycho-emotional state of 

patients with DU. with accompanying DC. 
Keywords DU, DC, frequency,  

The development of physiotherapeutic and biocorrective technologies of 

restorative medicine for diseases accompanied by the involvement in the pathological  

process of systems that provide adaptive reactions in the body, especially immune, 
metabolic, antitoxic, enzymatic, cytoprotective, etc., is one of the urgent tasks of 

modern medicine. (Krasnopolsky V.I. et al., 1999; Savelyeva G.M., 1999; Yaglov 

V.V., 2001; Vikhlyaeva EM, 2012). 
One of the components of the pathological symptom complex in duodenal 

ulcer disease is the development of dysbiotic conditions, which is associated, among 

other things, with the use of antibacterial therapy according to the recommendations 



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137 

of all the protocols of the Maastricht Consensus. In the scientific literature there are 

data indicating a 100% combination of some diseases with intestinal dysbiosis (DC) 
(Strizhova N.V. et al., 2001; Pasman N.M. et al., 2006), which leads to the formation 

of a syndrome of mutual burden , and thus complicates the treatment of this category 

of patients. The experience of using synbiotics (SG) in gastroenterological practice is 

widely presented in the literature (Gusakova E.V., 2005; Efendieva M.T. et al., 2006; 
Ushkalova E.A., 2007; Gionchetti P. et. Al, 2006; McFarland LV, 2006). The results 

of recent studies give reason to consider the methods of physical therapy as one of the 

most promising, given the possibility of their differentiated and targeted impact on 

various links of the pathogenesis of the disease, an increase in the adaptive and 
reserve capabilities of the body with a minimum risk of developing side and allergic 

reactions (Strugatsky V.M. et al. , 1999; Razumov A.N., 2002). 

 Various methods of physiotherapy are successfully used in gastroenterological 
practice. At the same time, the experience of using magnetotherapy in the treatment 

of intestinal diseases (Serdyuk V.V., 2004, Eremina A.A., 2007) is limited. The 

theoretical prerequisite for the use of magnetic therapy (MT) in patients with 

intestinal dysbiosis is the data of previous studies, indicating its beneficial effect on 
the state of the body's regulatory systems, an increase in adaptive reactions, an 

improvement in regional hemodynamics in patients with various pathologies (Bogo 

Lyubov V.M. . et al., 1998; Berkutova AM et al., 2000), which is important in the 
treatment of this category of patients. Immunity disorders play one of the central 

places in the pathogenesis of DU and DC. 

Savelyeva G.M. et al., 1997; V. I. Kulakov et al., 1998), in connection with 

which it was given attention to the study of the mechanism of action of MT as a 
method of monotherapy for localinfluence, as well as in combination with the extract 

of Ganoderma Lucidum on the state of the immune system. 

 Objective: to study the use of magnetic therapy in combination with 
Ganoderma Lucidum extract on the state of the immune system in the treatment of 

patients with duodenal ulcer disease with intestinal dysbiosis. 

Research methods: 90 patients with colonic dysbiosis, 53 women and 25 men, 

aged 18-65 years, were studied. 
In addition to general clinical studies, laboratory diagnostics of DC were 

carried out according to the method developed by F.L. Vilypanskoy (1970), 

endoscopic examination of the colon using the Olympus apparatus, histological 
examination of biopsy specimens of the colon mucosa, assessment of the immune 

status using tests that give an idea of the quantitative indicators of cellular and 

humoral immunity: T- and B-lymphocytes, immunoglobulins class G, A, M in 

peripheral blood (methods of MJondal al., 1972; I. Morettaetal., 1975; G. Mancini, 
1965), assessment of psychological status using a computer version of the SMOL 

(Abbreviated Multifactorial Questionnaire for Personality Research) according to the 

Hare method V.P. (1981), assessment of the psychosomatic state using the SAN test 
(well-being, activity, mood). The data obtained were processed by the methods of 

variation statistics using the Microsoft Excel (2007) software package on an IBM PC 

with the calculation of Student's t-criterion (as modified by Fisher). In the presence of 



Art of Medicine           Volume-1 

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138 

related samples, the Student's difference test was used. To assess the difference in 

shares (change in the presence of the sign as a percentage), the alternative F-test was 
used. Differences between mean values were considered significant at  

Treatment  methods. In accordance with the objectives of the study, all patients 

were divided into groups comparable in terms of the main clinical and physiological 

characteristics. Patients of the first group (30 patients) were treated with magnetic 
therapy (MT) from the "Olymp-1" apparatus. The impact was carried out by 4 pairs 

of inductors - solenoids on the area of projection of the organs of the large intestine; 

exposure parameters: intensity - 30% - 100%, frequency 10 Hz, magnetic induction 

value - 5 mT. The procedures were carried out daily, lasting 15-20 minutes. The 
course of treatment is 10-12 procedures. Patients of the second group (30 patients) 

underwent complex treatment: MT according to the above method, as well as a 

synbiotic consisting of an extract of Ganoderma Lucidum - 1 capsule 2 times a day 
with meals for 21 days 

 In the third comparison group (30 patients), the effect of MT from the 

“Olymp-1” apparatus (placebo) was imitated. The course of treatment consisted of 

10-12 procedures. Ganoderma Lucidum extract was included in the treatment 
complex according to the above scheme. 

Research results: 

Analysis of the dynamics of the immune status showed the benefits of complex 
treatment. This was characterized by the restoration of the balance of the 

immunoregulatory T-cell subpopulations Тƴ and Тµ and an improvement in their 

ratio due to a clearer differentiation of T-lymphocytes in the thymus, as well as a 

significant increase (p <0.05) of the immunoregulatory index. The study of the 
immunological parameters of the patients of the 1st and 3rd groups revealed the 

restoration of only the immunoregulatory subpopulation of Tµ-lymphocytes. At the 

immunoregulatory index did not change significantly. The final assessment of the 
effectiveness of the treatment showed the benefits complex therapy. So, at the end of 

the course of treatment, a significant improvement was noted 10% of patients in the 

1st, 40% - in the 2nd group; improvement in 46.7% of patients 1st, 43.3% 2nd and 

43.3% - 3rd group. 43.3% of patients in 1st, 16.7% - 2nd and 56.6 ° finished without 
treatment effect. 

- 3rd group. The values of the Pearson criterion in the distribution of treatment 

results in the two main groups versus the comparison group were, respectively, x2 = 
10.2; p = 0.038 x2 = 16.2; p = 0.014. Long-term results of treatment showed that, on 

average, the achieved positive treatment effects persisted for 3 months in 40% in 

group 1, in 66.7% in group 2 th group. Exacerbation of the disease after 3 months 

was noted in 28.6% of patients with 1st and 33.3% - 3rd group. In the 2nd group for 
the specified period of exacerbation of the inflammatory process was not observed. 

After 6 months, the positive effect persisted in 23.3% of patients 1 th; 46.7% - 2nd 

group. Exacerbation of the disease after 6 months occurred in 47.6% of pain1st, 
13.3% - 2nd and 57.1% - 3rd groups. After 12 months, the positive effect persisted. 

It was found in 13.3% of patients in the 1st and 35% in the 2nd groups. Exacerbation 

of the inflammatory process Res 12 months was observed in 66.7% of patients in the 



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139 

1st, and 66.7% in the 3rd and 20% in the 2nd groups. Bole high efficiency of 

treatment based on long-term results is verified reliably by the values of the Pearson 
x2 criterion for two main groups versus the control with were set integrally over 12 

months of observation (respectively for groups 1 and 2 - x2 = 23.8 

p = 0.026 and x2 = 28.5; p = 0.011). 

Thus, the results of the studies carried out made it possible to identify a number 
of positions. the positive effects of magnetotherapy in combination with the extract of 

ganoderma lucidum in the influence on various links in the pathogenesis of the 

studied pathology. The vasotropic effect plays an important role in the realization of 

the therapeutic effect of magnetotherapy. The result of the improvement in regional 
hemodynamics, which was observed in the majority of the surveyed, was a decrease 

in inflammation in the gastric mucosa, which, to a certain extent, contributed to the 

improvement of digestion. The most pronounced effect was observed in patients with 
initial intestinal dysbiosis. Complex treatment potentiates and prolongs the analgesic 

and anti-inflammatory effects, has an immunocorrective effect, promotes the growth 

of saccharolytic microflora, restores the dynamic balance of the intestinal microflora 

and biotope, improves the functional state of the intestine, positively affects the 
psycho-emotional state of patients with DU with concomitant DC. 

 

  



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