id	sid	tid	token	lemma	pos
artofmedicineimsj-8	1	1	volume-1	volume-1	PROPN
artofmedicineimsj-8	1	2	issue-1	issue-1	NUM
artofmedicineimsj-8	1	3	art	art	NOUN
artofmedicineimsj-8	1	4	of	of	ADP
artofmedicineimsj-8	1	5	medicine	medicine	NOUN
artofmedicineimsj-8	1	6	international	international	ADJ
artofmedicineimsj-8	1	7	medical	medical	ADJ
artofmedicineimsj-8	1	8	scientific	scientific	ADJ
artofmedicineimsj-8	1	9	journal	journal	NOUN
artofmedicineimsj-8	1	10	1	1	NUM
artofmedicineimsj-8	1	11	art	art	NOUN
artofmedicineimsj-8	1	12	of	of	ADP
artofmedicineimsj-8	1	13	medicine	medicine	NOUN
artofmedicineimsj-8	1	14	international	international	ADJ
artofmedicineimsj-8	1	15	medical	medical	ADJ
artofmedicineimsj-8	1	16	scientific	scientific	ADJ
artofmedicineimsj-8	1	17	journal	journal	NOUN
artofmedicineimsj-8	1	18	volume-1	volume-1	PROPN
artofmedicineimsj-8	1	19	issue-1	issue-1	PROPN
artofmedicineimsj-8	1	20	2	2	NUM
artofmedicineimsj-8	1	21	art	art	NOUN
artofmedicineimsj-8	1	22	of	of	ADP
artofmedicineimsj-8	1	23	medicine	medicine	NOUN
artofmedicineimsj-8	1	24	international	international	ADJ
artofmedicineimsj-8	1	25	medical	medical	ADJ
artofmedicineimsj-8	1	26	scientific	scientific	ADJ
artofmedicineimsj-8	1	27	journal	journal	NOUN
artofmedicineimsj-8	1	28	volume	volume	NOUN
artofmedicineimsj-8	1	29	1	1	NUM
artofmedicineimsj-8	1	30	,	,	PUNCT
artofmedicineimsj-8	1	31	issue	issue	NOUN
artofmedicineimsj-8	1	32	1	1	NUM
artofmedicineimsj-8	1	33	,	,	PUNCT
artofmedicineimsj-8	1	34	may	may	AUX
artofmedicineimsj-8	1	35	2021	2021	NUM
artofmedicineimsj-8	1	36	volume-1	volume-1	PROPN
artofmedicineimsj-8	1	37	issue-1	issue-1	NUM
artofmedicineimsj-8	1	38	art	art	NOUN
artofmedicineimsj-8	1	39	of	of	ADP
artofmedicineimsj-8	1	40	medicine	medicine	NOUN
artofmedicineimsj-8	1	41	international	international	ADJ
artofmedicineimsj-8	1	42	medical	medical	ADJ
artofmedicineimsj-8	1	43	scientific	scientific	ADJ
artofmedicineimsj-8	1	44	journal	journal	NOUN
artofmedicineimsj-8	1	45	3	3	NUM
artofmedicineimsj-8	1	46	founder	founder	NOUN
artofmedicineimsj-8	1	47	and	and	CCONJ
artofmedicineimsj-8	1	48	publisher	publisher	NOUN
artofmedicineimsj-8	1	49	pascual	pascual	PROPN
artofmedicineimsj-8	1	50	izquierdo	izquierdo	PROPN
artofmedicineimsj-8	1	51	-	-	PUNCT
artofmedicineimsj-8	1	52	egea	egea	NOUN
artofmedicineimsj-8	1	53	published	publish	VERB
artofmedicineimsj-8	1	54	science	science	NOUN
artofmedicineimsj-8	1	55	may	may	AUX
artofmedicineimsj-8	1	56	2021	2021	NUM
artofmedicineimsj-8	1	57	year	year	NOUN
artofmedicineimsj-8	1	58	.	.	PUNCT
artofmedicineimsj-8	1	59	issued	issue	VERB
artofmedicineimsj-8	1	60	quarterly	quarterly	ADV
artofmedicineimsj-8	1	61	.	.	PUNCT
artofmedicineimsj-8	2	1	internet	internet	NOUN
artofmedicineimsj-8	2	2	address	address	NOUN
artofmedicineimsj-8	2	3	:	:	PUNCT
artofmedicineimsj-8	2	4	http://artofmedicineimsj.us	http://artofmedicineimsj.us	PROPN
artofmedicineimsj-8	2	5	e	e	NOUN
artofmedicineimsj-8	2	6	-	-	NOUN
artofmedicineimsj-8	2	7	mail	mail	NOUN
artofmedicineimsj-8	2	8	:	:	PUNCT
artofmedicineimsj-8	2	9	info@artofmedicineimsj.us	info@artofmedicineimsj.us	PROPN
artofmedicineimsj-8	2	10	11931	11931	NUM
artofmedicineimsj-8	2	11	barlow	barlow	PROPN
artofmedicineimsj-8	2	12	pl	pl	PROPN
artofmedicineimsj-8	2	13	philadelphia	philadelphia	PROPN
artofmedicineimsj-8	2	14	,	,	PUNCT
artofmedicineimsj-8	2	15	pa	pa	PROPN
artofmedicineimsj-8	2	16	19116	19116	NUM
artofmedicineimsj-8	2	17	,	,	PUNCT
artofmedicineimsj-8	2	18	usa	usa	PROPN
artofmedicineimsj-8	2	19	+1	+1	PROPN
artofmedicineimsj-8	2	20	(	(	PUNCT
artofmedicineimsj-8	2	21	929	929	NUM
artofmedicineimsj-8	2	22	)	)	SYM
artofmedicineimsj-8	2	23	266	266	NUM
artofmedicineimsj-8	2	24	-	-	SYM
artofmedicineimsj-8	2	25	0862	0862	NUM
artofmedicineimsj-8	2	26	art	art	NOUN
artofmedicineimsj-8	2	27	of	of	ADP
artofmedicineimsj-8	2	28	medicine	medicine	NOUN
artofmedicineimsj-8	2	29	international	international	ADJ
artofmedicineimsj-8	2	30	medical	medical	ADJ
artofmedicineimsj-8	2	31	scientific	scientific	ADJ
artofmedicineimsj-8	2	32	journal	journal	NOUN
artofmedicineimsj-8	2	33	chief	chief	NOUN
artofmedicineimsj-8	2	34	editor	editor	NOUN
artofmedicineimsj-8	2	35	dr	dr	PROPN
artofmedicineimsj-8	2	36	.	.	PROPN
artofmedicineimsj-8	2	37	pascual	pascual	PROPN
artofmedicineimsj-8	2	38	izquierdo	izquierdo	PROPN
artofmedicineimsj-8	2	39	-	-	PUNCT
artofmedicineimsj-8	2	40	egea	egea	PROPN
artofmedicineimsj-8	2	41	editorial	editorial	NOUN
artofmedicineimsj-8	2	42	board	board	NOUN
artofmedicineimsj-8	2	43	prof	prof	PROPN
artofmedicineimsj-8	2	44	.	.	PUNCT
artofmedicineimsj-8	3	1	dr	dr	PROPN
artofmedicineimsj-8	3	2	.	.	PROPN
artofmedicineimsj-8	3	3	francesco	francesco	PROPN
artofmedicineimsj-8	3	4	albano	albano	PROPN
artofmedicineimsj-8	3	5	dr	dr	PROPN
artofmedicineimsj-8	3	6	.	.	PROPN
artofmedicineimsj-8	3	7	catherine	catherine	PROPN
artofmedicineimsj-8	3	8	j.	j.	PROPN
artofmedicineimsj-8	3	9	andersen	andersen	PROPN
artofmedicineimsj-8	3	10	prof	prof	PROPN
artofmedicineimsj-8	3	11	.	.	PUNCT
artofmedicineimsj-8	4	1	dr	dr	PROPN
artofmedicineimsj-8	4	2	.	.	PROPN
artofmedicineimsj-8	4	3	sandro	sandro	PROPN
artofmedicineimsj-8	4	4	ardizzone	ardizzone	PROPN
artofmedicineimsj-8	4	5	dr	dr	PROPN
artofmedicineimsj-8	4	6	.	.	PROPN
artofmedicineimsj-8	4	7	dmitriy	dmitriy	PROPN
artofmedicineimsj-8	4	8	atochin	atochin	PROPN
artofmedicineimsj-8	4	9	prof	prof	PROPN
artofmedicineimsj-8	4	10	.	.	PUNCT
artofmedicineimsj-8	5	1	dr	dr	PROPN
artofmedicineimsj-8	5	2	.	.	PROPN
artofmedicineimsj-8	5	3	antonio	antonio	PROPN
artofmedicineimsj-8	5	4	aversa	aversa	PROPN
artofmedicineimsj-8	5	5	prof	prof	PROPN
artofmedicineimsj-8	5	6	.	.	PUNCT
artofmedicineimsj-8	6	1	dr	dr	PROPN
artofmedicineimsj-8	6	2	.	.	PROPN
artofmedicineimsj-8	6	3	tamam	tamam	PROPN
artofmedicineimsj-8	6	4	bakchoul	bakchoul	PROPN
artofmedicineimsj-8	6	5	prof	prof	PROPN
artofmedicineimsj-8	6	6	.	.	PUNCT
artofmedicineimsj-8	7	1	dr	dr	PROPN
artofmedicineimsj-8	7	2	.	.	PROPN
artofmedicineimsj-8	7	3	pierre	pierre	PROPN
artofmedicineimsj-8	7	4	-	-	PUNCT
artofmedicineimsj-8	7	5	gregoire	gregoire	PROPN
artofmedicineimsj-8	7	6	guinot	guinot	PROPN
artofmedicineimsj-8	7	7	prof	prof	PROPN
artofmedicineimsj-8	7	8	.	.	PUNCT
artofmedicineimsj-8	8	1	dr	dr	PROPN
artofmedicineimsj-8	8	2	.	.	PROPN
artofmedicineimsj-8	8	3	rainer	rainer	PROPN
artofmedicineimsj-8	8	4	haak	haak	PROPN
artofmedicineimsj-8	8	5	prof	prof	PROPN
artofmedicineimsj-8	8	6	.	.	PUNCT
artofmedicineimsj-8	9	1	henner	henner	PROPN
artofmedicineimsj-8	9	2	hanssen	hanssen	PROPN
artofmedicineimsj-8	9	3	art	art	PROPN
artofmedicineimsj-8	9	4	of	of	ADP
artofmedicineimsj-8	9	5	medicine	medicine	PROPN
artofmedicineimsj-8	9	6	international	international	ADJ
artofmedicineimsj-8	9	7	medical	medical	ADJ
artofmedicineimsj-8	9	8	scientific	scientific	ADJ
artofmedicineimsj-8	9	9	journal	journal	NOUN
artofmedicineimsj-8	9	10	volume-1	volume-1	PROPN
artofmedicineimsj-8	9	11	issue-1	issue-1	PROPN
artofmedicineimsj-8	9	12	4	4	NUM
artofmedicineimsj-8	9	13	content	content	NOUN
artofmedicineimsj-8	9	14	tursunova	tursunova	PROPN
artofmedicineimsj-8	9	15	l.	l.	PROPN
artofmedicineimsj-8	9	16	d.	d.	PROPN
artofmedicineimsj-8	9	17	,	,	PUNCT
artofmedicineimsj-8	9	18	jabbarov	jabbarov	PROPN
artofmedicineimsj-8	9	19	o.	o.	PROPN
artofmedicineimsj-8	9	20	o.	o.	PROPN
artofmedicineimsj-8	9	21	application	application	NOUN
artofmedicineimsj-8	9	22	of	of	ADP
artofmedicineimsj-8	9	23	sakabutril	sakabutril	NOUN
artofmedicineimsj-8	9	24	/	/	SYM
artofmedicineimsj-8	9	25	valsartan	valsartan	PROPN
artofmedicineimsj-8	9	26	in	in	ADP
artofmedicineimsj-8	9	27	patients	patient	NOUN
artofmedicineimsj-8	9	28	with	with	ADP
artofmedicineimsj-8	9	29	chronic	chronic	ADJ
artofmedicineimsj-8	9	30	kidney	kidney	NOUN
artofmedicineimsj-8	9	31	disease	disease	NOUN
artofmedicineimsj-8	9	32	with	with	ADP
artofmedicineimsj-8	9	33	type	type	NOUN
artofmedicineimsj-8	9	34	2	2	NUM
artofmedicineimsj-8	9	35	diabetes	diabetes	NOUN
artofmedicineimsj-8	9	36	mellitus	mellitus	NOUN
artofmedicineimsj-8	9	37	...............................	...............................	PUNCT
artofmedicineimsj-8	9	38	5	5	NUM
artofmedicineimsj-8	9	39	l.s	l.s	PROPN
artofmedicineimsj-8	9	40	.	.	PROPN
artofmedicineimsj-8	9	41	khamraeva	khamraeva	PROPN
artofmedicineimsj-8	9	42	.	.	PROPN
artofmedicineimsj-8	9	43	,	,	PUNCT
artofmedicineimsj-8	9	44	d.u	d.u	PROPN
artofmedicineimsj-8	9	45	.	.	PROPN
artofmedicineimsj-8	9	46	narzullaeva	narzullaeva	PROPN
artofmedicineimsj-8	9	47	features	feature	NOUN
artofmedicineimsj-8	9	48	of	of	ADP
artofmedicineimsj-8	9	49	calculating	calculate	VERB
artofmedicineimsj-8	9	50	the	the	DET
artofmedicineimsj-8	9	51	optical	optical	ADJ
artofmedicineimsj-8	9	52	power	power	NOUN
artofmedicineimsj-8	9	53	of	of	ADP
artofmedicineimsj-8	9	54	an	an	DET
artofmedicineimsj-8	9	55	intraocular	intraocular	ADJ
artofmedicineimsj-8	9	56	lens	lens	NOUN
artofmedicineimsj-8	9	57	in	in	ADP
artofmedicineimsj-8	9	58	children	child	NOUN
artofmedicineimsj-8	9	59	with	with	ADP
artofmedicineimsj-8	9	60	congenital	congenital	ADJ
artofmedicineimsj-8	9	61	cataracts	cataract	NOUN
artofmedicineimsj-8	9	62	at	at	ADP
artofmedicineimsj-8	9	63	the	the	DET
artofmedicineimsj-8	9	64	risk	risk	NOUN
artofmedicineimsj-8	9	65	of	of	ADP
artofmedicineimsj-8	9	66	developing	develop	VERB
artofmedicineimsj-8	9	67	pseudomyopic	pseudomyopic	ADJ
artofmedicineimsj-8	9	68	myopia	myopia	NOUN
artofmedicineimsj-8	9	69	.....................	.....................	SYM
artofmedicineimsj-8	9	70	10	10	NUM
artofmedicineimsj-8	9	71	kasimova	kasimova	PROPN
artofmedicineimsj-8	9	72	m.	m.	PROPN
artofmedicineimsj-8	9	73	s.	s.	PROPN
artofmedicineimsj-8	9	74	,	,	PUNCT
artofmedicineimsj-8	9	75	iminova	iminova	VERB
artofmedicineimsj-8	9	76	m.	m.	NOUN
artofmedicineimsj-8	9	77	m.	m.	NOUN
artofmedicineimsj-8	9	78	,	,	PUNCT
artofmedicineimsj-8	9	79	ashurov	ashurov	NOUN
artofmedicineimsj-8	9	80	o.	o.	PROPN
artofmedicineimsj-8	9	81	m.	m.	PROPN
artofmedicineimsj-8	9	82	ophthalmologic	ophthalmologic	ADJ
artofmedicineimsj-8	9	83	complications	complication	NOUN
artofmedicineimsj-8	9	84	in	in	ADP
artofmedicineimsj-8	9	85	the	the	DET
artofmedicineimsj-8	9	86	structure	structure	NOUN
artofmedicineimsj-8	9	87	of	of	ADP
artofmedicineimsj-8	9	88	the	the	DET
artofmedicineimsj-8	9	89	clinical	clinical	ADJ
artofmedicineimsj-8	9	90	features	feature	NOUN
artofmedicineimsj-8	9	91	of	of	ADP
artofmedicineimsj-8	9	92	novel	novel	ADJ
artofmedicineimsj-8	9	93	coronavirus	coronavirus	NOUN
artofmedicineimsj-8	9	94	infection	infection	NOUN
artofmedicineimsj-8	9	95	(	(	PUNCT
artofmedicineimsj-8	9	96	covid-19)	covid-19)	NOUN
artofmedicineimsj-8	9	97	......................................................................................................	......................................................................................................	NOUN
artofmedicineimsj-8	9	98	14	14	NUM
artofmedicineimsj-8	9	99	fattayeva	fattayeva	PROPN
artofmedicineimsj-8	9	100	d.r	d.r	PROPN
artofmedicineimsj-8	9	101	.	.	PROPN
artofmedicineimsj-8	9	102	,	,	PUNCT
artofmedicineimsj-8	9	103	rizayev	rizayev	PROPN
artofmedicineimsj-8	9	104	j.a	j.a	PROPN
artofmedicineimsj-8	9	105	.	.	PROPN
artofmedicineimsj-8	9	106	,	,	PUNCT
artofmedicineimsj-8	9	107	rakhimova	rakhimova	PROPN
artofmedicineimsj-8	9	108	d.a	d.a	PROPN
artofmedicineimsj-8	9	109	.	.	PROPN
artofmedicineimsj-8	9	110	improvement	improvement	NOUN
artofmedicineimsj-8	9	111	of	of	ADP
artofmedicineimsj-8	9	112	methods	method	NOUN
artofmedicineimsj-8	9	113	for	for	ADP
artofmedicineimsj-8	9	114	correction	correction	NOUN
artofmedicineimsj-8	9	115	of	of	ADP
artofmedicineimsj-8	9	116	clinical	clinical	ADJ
artofmedicineimsj-8	9	117	and	and	CCONJ
artofmedicineimsj-8	9	118	immunological	immunological	ADJ
artofmedicineimsj-8	9	119	disorders	disorder	NOUN
artofmedicineimsj-8	9	120	in	in	ADP
artofmedicineimsj-8	9	121	comorbid	comorbid	NOUN
artofmedicineimsj-8	9	122	state	state	NOUN
artofmedicineimsj-8	9	123	of	of	ADP
artofmedicineimsj-8	9	124	chronic	chronic	ADJ
artofmedicineimsj-8	9	125	gaymoritis	gaymoritis	NOUN
artofmedicineimsj-8	9	126	after	after	ADP
artofmedicineimsj-8	9	127	covid-19	covid-19	PROPN
artofmedicineimsj-8	9	128	....................................................................	....................................................................	PROPN
artofmedicineimsj-8	9	129	17	17	NUM
artofmedicineimsj-8	9	130	polatova	polatova	PROPN
artofmedicineimsj-8	9	131	d.sh	d.sh	NOUN
artofmedicineimsj-8	9	132	.	.	PROPN
artofmedicineimsj-8	9	133	,	,	PUNCT
artofmedicineimsj-8	9	134	abdukarimov	abdukarimov	PROPN
artofmedicineimsj-8	9	135	kh.g	kh.g	PROPN
artofmedicineimsj-8	9	136	.	.	PROPN
artofmedicineimsj-8	9	137	,	,	PUNCT
artofmedicineimsj-8	9	138	davletov	davletov	PROPN
artofmedicineimsj-8	9	139	r.r	r.r	PROPN
artofmedicineimsj-8	9	140	.	.	PROPN
artofmedicineimsj-8	9	141	,	,	PUNCT
artofmedicineimsj-8	9	142	savkin	savkin	PROPN
artofmedicineimsj-8	9	143	a.v	a.v	PROPN
artofmedicineimsj-8	9	144	.	.	PROPN
artofmedicineimsj-8	9	145	,	,	PUNCT
artofmedicineimsj-8	9	146	sultanov	sultanov	VERB
artofmedicineimsj-8	9	147	b.b	b.b	PROPN
artofmedicineimsj-8	9	148	features	feature	NOUN
artofmedicineimsj-8	9	149	of	of	ADP
artofmedicineimsj-8	9	150	immunobiological	immunobiological	ADJ
artofmedicineimsj-8	9	151	heterogeneity	heterogeneity	NOUN
artofmedicineimsj-8	9	152	in	in	ADP
artofmedicineimsj-8	9	153	patients	patient	NOUN
artofmedicineimsj-8	9	154	with	with	ADP
artofmedicineimsj-8	9	155	osteosarcoma	osteosarcoma	ADJ
artofmedicineimsj-8	9	156	.................................................................................	.................................................................................	PUNCT
artofmedicineimsj-8	9	157	25	25	NUM
artofmedicineimsj-8	9	158	volume-1	volume-1	PROPN
artofmedicineimsj-8	9	159	issue-1	issue-1	NUM
artofmedicineimsj-8	9	160	art	art	NOUN
artofmedicineimsj-8	9	161	of	of	ADP
artofmedicineimsj-8	9	162	medicine	medicine	NOUN
artofmedicineimsj-8	9	163	international	international	ADJ
artofmedicineimsj-8	9	164	medical	medical	ADJ
artofmedicineimsj-8	9	165	scientific	scientific	ADJ
artofmedicineimsj-8	9	166	journal	journal	NOUN
artofmedicineimsj-8	9	167	5	5	NUM
artofmedicineimsj-8	9	168	application	application	NOUN
artofmedicineimsj-8	9	169	of	of	ADP
artofmedicineimsj-8	9	170	sakabutril	sakabutril	NOUN
artofmedicineimsj-8	9	171	/	/	SYM
artofmedicineimsj-8	9	172	valsartan	valsartan	PROPN
artofmedicineimsj-8	9	173	in	in	ADP
artofmedicineimsj-8	9	174	patients	patient	NOUN
artofmedicineimsj-8	9	175	with	with	ADP
artofmedicineimsj-8	9	176	chronic	chronic	ADJ
artofmedicineimsj-8	9	177	kidney	kidney	NOUN
artofmedicineimsj-8	9	178	disease	disease	NOUN
artofmedicineimsj-8	9	179	with	with	ADP
artofmedicineimsj-8	9	180	type	type	NOUN
artofmedicineimsj-8	9	181	2	2	NUM
artofmedicineimsj-8	9	182	diabetes	diabetes	NOUN
artofmedicineimsj-8	9	183	mellitus	mellitus	NOUN
artofmedicineimsj-8	9	184	tursunova	tursunova	PROPN
artofmedicineimsj-8	9	185	laylo	laylo	PROPN
artofmedicineimsj-8	9	186	dilshatovna	dilshatovna	NOUN
artofmedicineimsj-8	9	187	,	,	PUNCT
artofmedicineimsj-8	9	188	jabbarov	jabbarov	PROPN
artofmedicineimsj-8	9	189	ozimbay	ozimbay	PROPN
artofmedicineimsj-8	9	190	otaxonovich	otaxonovich	PRON
artofmedicineimsj-8	9	191	tashkent	tashkent	PROPN
artofmedicineimsj-8	9	192	medical	medical	PROPN
artofmedicineimsj-8	9	193	academy	academy	PROPN
artofmedicineimsj-8	9	194	,	,	PUNCT
artofmedicineimsj-8	9	195	tashkent	tashkent	PROPN
artofmedicineimsj-8	9	196	,	,	PUNCT
artofmedicineimsj-8	9	197	uzbekistan	uzbekistan	PROPN
artofmedicineimsj-8	9	198	abstract	abstract	ADJ
artofmedicineimsj-8	9	199	chronic	chronic	ADJ
artofmedicineimsj-8	9	200	kidney	kidney	NOUN
artofmedicineimsj-8	9	201	disease	disease	NOUN
artofmedicineimsj-8	9	202	(	(	PUNCT
artofmedicineimsj-8	9	203	ckd	ckd	NOUN
artofmedicineimsj-8	9	204	)	)	PUNCT
artofmedicineimsj-8	9	205	is	be	AUX
artofmedicineimsj-8	9	206	a	a	DET
artofmedicineimsj-8	9	207	generalized	generalized	ADJ
artofmedicineimsj-8	9	208	term	term	NOUN
artofmedicineimsj-8	9	209	that	that	PRON
artofmedicineimsj-8	9	210	indicates	indicate	VERB
artofmedicineimsj-8	9	211	damage	damage	NOUN
artofmedicineimsj-8	9	212	to	to	ADP
artofmedicineimsj-8	9	213	the	the	DET
artofmedicineimsj-8	9	214	renal	renal	ADJ
artofmedicineimsj-8	9	215	tissue	tissue	NOUN
artofmedicineimsj-8	9	216	,	,	PUNCT
artofmedicineimsj-8	9	217	regardless	regardless	ADV
artofmedicineimsj-8	9	218	of	of	ADP
artofmedicineimsj-8	9	219	the	the	DET
artofmedicineimsj-8	9	220	etiology	etiology	NOUN
artofmedicineimsj-8	9	221	of	of	ADP
artofmedicineimsj-8	9	222	the	the	DET
artofmedicineimsj-8	9	223	underlying	underlie	VERB
artofmedicineimsj-8	9	224	disease	disease	NOUN
artofmedicineimsj-8	9	225	.	.	PUNCT
artofmedicineimsj-8	10	1	ckd	ckd	PROPN
artofmedicineimsj-8	10	2	develops	develop	VERB
artofmedicineimsj-8	10	3	in	in	ADP
artofmedicineimsj-8	10	4	every	every	DET
artofmedicineimsj-8	10	5	second	second	ADJ
artofmedicineimsj-8	10	6	patient	patient	NOUN
artofmedicineimsj-8	10	7	with	with	ADP
artofmedicineimsj-8	10	8	diabetes	diabetes	NOUN
artofmedicineimsj-8	10	9	mellitus	mellitus	NOUN
artofmedicineimsj-8	10	10	(	(	PUNCT
artofmedicineimsj-8	10	11	dm	dm	PROPN
artofmedicineimsj-8	10	12	)	)	PUNCT
artofmedicineimsj-8	10	13	and	and	CCONJ
artofmedicineimsj-8	10	14	significantly	significantly	ADV
artofmedicineimsj-8	10	15	limits	limit	VERB
artofmedicineimsj-8	10	16	the	the	DET
artofmedicineimsj-8	10	17	duration	duration	NOUN
artofmedicineimsj-8	10	18	and	and	CCONJ
artofmedicineimsj-8	10	19	quality	quality	NOUN
artofmedicineimsj-8	10	20	of	of	ADP
artofmedicineimsj-8	10	21	life	life	NOUN
artofmedicineimsj-8	10	22	.	.	PUNCT
artofmedicineimsj-8	11	1	ckd	ckd	PROPN
artofmedicineimsj-8	11	2	is	be	AUX
artofmedicineimsj-8	11	3	diagnosed	diagnose	VERB
artofmedicineimsj-8	11	4	by	by	ADP
artofmedicineimsj-8	11	5	the	the	DET
artofmedicineimsj-8	11	6	level	level	NOUN
artofmedicineimsj-8	11	7	of	of	ADP
artofmedicineimsj-8	11	8	glomerular	glomerular	ADJ
artofmedicineimsj-8	11	9	filtration	filtration	NOUN
artofmedicineimsj-8	11	10	rate	rate	NOUN
artofmedicineimsj-8	11	11	(	(	PUNCT
artofmedicineimsj-8	11	12	gfr	gfr	NOUN
artofmedicineimsj-8	11	13	)	)	PUNCT
artofmedicineimsj-8	11	14	,	,	PUNCT
artofmedicineimsj-8	11	15	which	which	PRON
artofmedicineimsj-8	11	16	is	be	AUX
artofmedicineimsj-8	11	17	recognized	recognize	VERB
artofmedicineimsj-8	11	18	as	as	ADP
artofmedicineimsj-8	11	19	the	the	DET
artofmedicineimsj-8	11	20	most	most	ADV
artofmedicineimsj-8	11	21	fully	fully	ADV
artofmedicineimsj-8	11	22	reflecting	reflect	VERB
artofmedicineimsj-8	11	23	the	the	DET
artofmedicineimsj-8	11	24	number	number	NOUN
artofmedicineimsj-8	11	25	and	and	CCONJ
artofmedicineimsj-8	11	26	total	total	ADJ
artofmedicineimsj-8	11	27	volume	volume	NOUN
artofmedicineimsj-8	11	28	of	of	ADP
artofmedicineimsj-8	11	29	nephrons	nephron	NOUN
artofmedicineimsj-8	11	30	.	.	PUNCT
artofmedicineimsj-8	12	1	the	the	DET
artofmedicineimsj-8	12	2	article	article	NOUN
artofmedicineimsj-8	12	3	presents	present	VERB
artofmedicineimsj-8	12	4	data	datum	NOUN
artofmedicineimsj-8	12	5	on	on	ADP
artofmedicineimsj-8	12	6	disturbances	disturbance	NOUN
artofmedicineimsj-8	12	7	of	of	ADP
artofmedicineimsj-8	12	8	the	the	DET
artofmedicineimsj-8	12	9	excretory	excretory	NOUN
artofmedicineimsj-8	12	10	and	and	CCONJ
artofmedicineimsj-8	12	11	filtration	filtration	NOUN
artofmedicineimsj-8	12	12	functions	function	NOUN
artofmedicineimsj-8	12	13	of	of	ADP
artofmedicineimsj-8	12	14	the	the	DET
artofmedicineimsj-8	12	15	kidneys	kidney	NOUN
artofmedicineimsj-8	12	16	,	,	PUNCT
artofmedicineimsj-8	12	17	as	as	ADV
artofmedicineimsj-8	12	18	well	well	ADV
artofmedicineimsj-8	12	19	as	as	ADP
artofmedicineimsj-8	12	20	lipid	lipid	ADJ
artofmedicineimsj-8	12	21	metabolism	metabolism	NOUN
artofmedicineimsj-8	12	22	in	in	ADP
artofmedicineimsj-8	12	23	patients	patient	NOUN
artofmedicineimsj-8	12	24	with	with	ADP
artofmedicineimsj-8	12	25	chronic	chronic	ADJ
artofmedicineimsj-8	12	26	kidney	kidney	NOUN
artofmedicineimsj-8	12	27	disease	disease	NOUN
artofmedicineimsj-8	12	28	.	.	PUNCT
artofmedicineimsj-8	13	1	the	the	DET
artofmedicineimsj-8	13	2	experience	experience	NOUN
artofmedicineimsj-8	13	3	of	of	ADP
artofmedicineimsj-8	13	4	the	the	DET
artofmedicineimsj-8	13	5	clinical	clinical	ADJ
artofmedicineimsj-8	13	6	use	use	NOUN
artofmedicineimsj-8	13	7	of	of	ADP
artofmedicineimsj-8	13	8	sacubitril	sacubitril	ADJ
artofmedicineimsj-8	13	9	/	/	PUNCT
artofmedicineimsj-8	13	10	valsartan	valsartan	ADJ
artofmedicineimsj-8	13	11	in	in	ADP
artofmedicineimsj-8	13	12	patients	patient	NOUN
artofmedicineimsj-8	13	13	of	of	ADP
artofmedicineimsj-8	13	14	this	this	DET
artofmedicineimsj-8	13	15	category	category	NOUN
artofmedicineimsj-8	13	16	is	be	AUX
artofmedicineimsj-8	13	17	presented	present	VERB
artofmedicineimsj-8	13	18	in	in	ADP
artofmedicineimsj-8	13	19	order	order	NOUN
artofmedicineimsj-8	13	20	to	to	PART
artofmedicineimsj-8	13	21	study	study	VERB
artofmedicineimsj-8	13	22	their	their	PRON
artofmedicineimsj-8	13	23	functional	functional	ADJ
artofmedicineimsj-8	13	24	state	state	NOUN
artofmedicineimsj-8	13	25	of	of	ADP
artofmedicineimsj-8	13	26	the	the	DET
artofmedicineimsj-8	13	27	kidneys	kidney	NOUN
artofmedicineimsj-8	13	28	.	.	PUNCT
artofmedicineimsj-8	14	1	the	the	DET
artofmedicineimsj-8	14	2	patients	patient	NOUN
artofmedicineimsj-8	14	3	were	be	AUX
artofmedicineimsj-8	14	4	divided	divide	VERB
artofmedicineimsj-8	14	5	into	into	ADP
artofmedicineimsj-8	14	6	two	two	NUM
artofmedicineimsj-8	14	7	groups	group	NOUN
artofmedicineimsj-8	14	8	.	.	PUNCT
artofmedicineimsj-8	15	1	the	the	DET
artofmedicineimsj-8	15	2	first	first	ADJ
artofmedicineimsj-8	15	3	group	group	NOUN
artofmedicineimsj-8	15	4	of	of	ADP
artofmedicineimsj-8	15	5	patients	patient	NOUN
artofmedicineimsj-8	15	6	during	during	ADP
artofmedicineimsj-8	15	7	the	the	DET
artofmedicineimsj-8	15	8	treatment	treatment	NOUN
artofmedicineimsj-8	15	9	took	take	VERB
artofmedicineimsj-8	15	10	sacubitril	sacubitril	ADV
artofmedicineimsj-8	15	11	/	/	SYM
artofmedicineimsj-8	15	12	valsartan	valsartan	VERB
artofmedicineimsj-8	15	13	200	200	NUM
artofmedicineimsj-8	15	14	mg	mg	PROPN
artofmedicineimsj-8	15	15	/	/	SYM
artofmedicineimsj-8	15	16	day	day	NOUN
artofmedicineimsj-8	15	17	,	,	PUNCT
artofmedicineimsj-8	15	18	the	the	DET
artofmedicineimsj-8	15	19	second	second	ADJ
artofmedicineimsj-8	15	20	group	group	NOUN
artofmedicineimsj-8	15	21	valsartan	valsartan	VERB
artofmedicineimsj-8	15	22	160	160	NUM
artofmedicineimsj-8	15	23	mg	mg	PROPN
artofmedicineimsj-8	15	24	/	/	SYM
artofmedicineimsj-8	15	25	day	day	NOUN
artofmedicineimsj-8	15	26	.	.	PUNCT
artofmedicineimsj-8	16	1	the	the	DET
artofmedicineimsj-8	16	2	functional	functional	ADJ
artofmedicineimsj-8	16	3	state	state	NOUN
artofmedicineimsj-8	16	4	of	of	ADP
artofmedicineimsj-8	16	5	the	the	DET
artofmedicineimsj-8	16	6	kidneys	kidney	NOUN
artofmedicineimsj-8	16	7	and	and	CCONJ
artofmedicineimsj-8	16	8	heart	heart	NOUN
artofmedicineimsj-8	16	9	was	be	AUX
artofmedicineimsj-8	16	10	assessed	assess	VERB
artofmedicineimsj-8	16	11	on	on	ADP
artofmedicineimsj-8	16	12	the	the	DET
artofmedicineimsj-8	16	13	basis	basis	NOUN
artofmedicineimsj-8	16	14	of	of	ADP
artofmedicineimsj-8	16	15	clinical	clinical	ADJ
artofmedicineimsj-8	16	16	and	and	CCONJ
artofmedicineimsj-8	16	17	laboratory	laboratory	NOUN
artofmedicineimsj-8	16	18	parameters	parameter	NOUN
artofmedicineimsj-8	16	19	.	.	PUNCT
artofmedicineimsj-8	17	1	on	on	ADP
artofmedicineimsj-8	17	2	the	the	DET
artofmedicineimsj-8	17	3	30th	30th	ADJ
artofmedicineimsj-8	17	4	day	day	NOUN
artofmedicineimsj-8	17	5	of	of	ADP
artofmedicineimsj-8	17	6	treatment	treatment	NOUN
artofmedicineimsj-8	17	7	,	,	PUNCT
artofmedicineimsj-8	17	8	these	these	DET
artofmedicineimsj-8	17	9	parameters	parameter	NOUN
artofmedicineimsj-8	17	10	were	be	AUX
artofmedicineimsj-8	17	11	monitored	monitor	VERB
artofmedicineimsj-8	17	12	.	.	PUNCT
artofmedicineimsj-8	18	1	the	the	DET
artofmedicineimsj-8	18	2	positive	positive	ADJ
artofmedicineimsj-8	18	3	effect	effect	NOUN
artofmedicineimsj-8	18	4	of	of	ADP
artofmedicineimsj-8	18	5	this	this	DET
artofmedicineimsj-8	18	6	combination	combination	NOUN
artofmedicineimsj-8	18	7	on	on	ADP
artofmedicineimsj-8	18	8	some	some	DET
artofmedicineimsj-8	18	9	biochemical	biochemical	ADJ
artofmedicineimsj-8	18	10	parameters	parameter	NOUN
artofmedicineimsj-8	18	11	,	,	PUNCT
artofmedicineimsj-8	18	12	blood	blood	NOUN
artofmedicineimsj-8	18	13	lipid	lipid	NOUN
artofmedicineimsj-8	18	14	spectrum	spectrum	NOUN
artofmedicineimsj-8	18	15	and	and	CCONJ
artofmedicineimsj-8	18	16	renal	renal	ADJ
artofmedicineimsj-8	18	17	function	function	NOUN
artofmedicineimsj-8	18	18	was	be	AUX
artofmedicineimsj-8	18	19	noted	note	VERB
artofmedicineimsj-8	18	20	.	.	PUNCT
artofmedicineimsj-8	19	1	key	key	ADJ
artofmedicineimsj-8	19	2	words	word	NOUN
artofmedicineimsj-8	19	3	:	:	PUNCT
artofmedicineimsj-8	19	4	сhronic	сhronic	ADJ
artofmedicineimsj-8	19	5	kidney	kidney	NOUN
artofmedicineimsj-8	19	6	disease	disease	NOUN
artofmedicineimsj-8	19	7	,	,	PUNCT
artofmedicineimsj-8	19	8	diabetes	diabetes	NOUN
artofmedicineimsj-8	19	9	mellitus	mellitus	NOUN
artofmedicineimsj-8	19	10	,	,	PUNCT
artofmedicineimsj-8	19	11	diabetic	diabetic	ADJ
artofmedicineimsj-8	19	12	nephropathy	nephropathy	NOUN
artofmedicineimsj-8	19	13	,	,	PUNCT
artofmedicineimsj-8	19	14	glomerular	glomerular	ADJ
artofmedicineimsj-8	19	15	filtration	filtration	NOUN
artofmedicineimsj-8	19	16	rate	rate	NOUN
artofmedicineimsj-8	19	17	,	,	PUNCT
artofmedicineimsj-8	19	18	natriuretic	natriuretic	ADJ
artofmedicineimsj-8	19	19	peptide	peptide	NOUN
artofmedicineimsj-8	19	20	.	.	PUNCT
artofmedicineimsj-8	20	1	introduction	introduction	NOUN
artofmedicineimsj-8	20	2	in	in	ADP
artofmedicineimsj-8	20	3	2002	2002	NUM
artofmedicineimsj-8	20	4	,	,	PUNCT
artofmedicineimsj-8	20	5	the	the	DET
artofmedicineimsj-8	20	6	national	national	PROPN
artofmedicineimsj-8	20	7	kidney	kidney	PROPN
artofmedicineimsj-8	20	8	foundation	foundation	PROPN
artofmedicineimsj-8	20	9	,	,	PUNCT
artofmedicineimsj-8	20	10	in	in	ADP
artofmedicineimsj-8	20	11	order	order	NOUN
artofmedicineimsj-8	20	12	to	to	PART
artofmedicineimsj-8	20	13	unify	unify	VERB
artofmedicineimsj-8	20	14	approaches	approach	NOUN
artofmedicineimsj-8	20	15	to	to	ADP
artofmedicineimsj-8	20	16	the	the	DET
artofmedicineimsj-8	20	17	diagnosis	diagnosis	NOUN
artofmedicineimsj-8	20	18	and	and	CCONJ
artofmedicineimsj-8	20	19	treatment	treatment	NOUN
artofmedicineimsj-8	20	20	of	of	ADP
artofmedicineimsj-8	20	21	kidney	kidney	NOUN
artofmedicineimsj-8	20	22	diseases	disease	NOUN
artofmedicineimsj-8	20	23	,	,	PUNCT
artofmedicineimsj-8	20	24	proposed	propose	VERB
artofmedicineimsj-8	20	25	calling	call	VERB
artofmedicineimsj-8	20	26	chronic	chronic	ADJ
artofmedicineimsj-8	20	27	kidney	kidney	NOUN
artofmedicineimsj-8	20	28	disease	disease	NOUN
artofmedicineimsj-8	20	29	(	(	PUNCT
artofmedicineimsj-8	20	30	ckd	ckd	NOUN
artofmedicineimsj-8	20	31	)	)	PUNCT
artofmedicineimsj-8	20	32	structural	structural	ADJ
artofmedicineimsj-8	20	33	and	and	CCONJ
artofmedicineimsj-8	20	34	functional	functional	ADJ
artofmedicineimsj-8	20	35	changes	change	NOUN
artofmedicineimsj-8	20	36	in	in	ADP
artofmedicineimsj-8	20	37	the	the	DET
artofmedicineimsj-8	20	38	kidneys	kidney	NOUN
artofmedicineimsj-8	20	39	lasting	last	VERB
artofmedicineimsj-8	20	40	3	3	NUM
artofmedicineimsj-8	20	41	months	month	NOUN
artofmedicineimsj-8	20	42	or	or	CCONJ
artofmedicineimsj-8	20	43	more	more	ADJ
artofmedicineimsj-8	20	44	,	,	PUNCT
artofmedicineimsj-8	20	45	regardless	regardless	ADV
artofmedicineimsj-8	20	46	of	of	ADP
artofmedicineimsj-8	20	47	what	what	PRON
artofmedicineimsj-8	20	48	diseases	disease	NOUN
artofmedicineimsj-8	20	49	caused	cause	VERB
artofmedicineimsj-8	20	50	them	they	PRON
artofmedicineimsj-8	20	51	.	.	PUNCT
artofmedicineimsj-8	21	1	[	[	X
artofmedicineimsj-8	21	2	15	15	NUM
artofmedicineimsj-8	21	3	]	]	PUNCT
artofmedicineimsj-8	21	4	.	.	PUNCT
artofmedicineimsj-8	22	1	ckd	ckd	PROPN
artofmedicineimsj-8	22	2	also	also	ADV
artofmedicineimsj-8	22	3	includes	include	VERB
artofmedicineimsj-8	22	4	a	a	DET
artofmedicineimsj-8	22	5	decrease	decrease	NOUN
artofmedicineimsj-8	22	6	in	in	ADP
artofmedicineimsj-8	22	7	the	the	DET
artofmedicineimsj-8	22	8	glomerular	glomerular	ADJ
artofmedicineimsj-8	22	9	filtration	filtration	NOUN
artofmedicineimsj-8	22	10	rate	rate	NOUN
artofmedicineimsj-8	22	11	(	(	PUNCT
artofmedicineimsj-8	22	12	gfr	gfr	NOUN
artofmedicineimsj-8	22	13	)	)	PUNCT
artofmedicineimsj-8	22	14	of	of	ADP
artofmedicineimsj-8	22	15	less	less	ADJ
artofmedicineimsj-8	22	16	than	than	ADP
artofmedicineimsj-8	22	17	60	60	NUM
artofmedicineimsj-8	22	18	ml	ml	NOUN
artofmedicineimsj-8	22	19	/	/	SYM
artofmedicineimsj-8	22	20	min	min	NOUN
artofmedicineimsj-8	22	21	per	per	ADP
artofmedicineimsj-8	22	22	1.73	1.73	NUM
artofmedicineimsj-8	22	23	m2	m2	NOUN
artofmedicineimsj-8	22	24	,	,	PUNCT
artofmedicineimsj-8	22	25	which	which	PRON
artofmedicineimsj-8	22	26	persists	persist	VERB
artofmedicineimsj-8	22	27	for	for	ADP
artofmedicineimsj-8	22	28	3	3	NUM
artofmedicineimsj-8	22	29	months	month	NOUN
artofmedicineimsj-8	22	30	or	or	CCONJ
artofmedicineimsj-8	22	31	more	more	ADJ
artofmedicineimsj-8	22	32	,	,	PUNCT
artofmedicineimsj-8	22	33	even	even	ADV
artofmedicineimsj-8	22	34	if	if	SCONJ
artofmedicineimsj-8	22	35	there	there	PRON
artofmedicineimsj-8	22	36	are	be	VERB
artofmedicineimsj-8	22	37	no	no	DET
artofmedicineimsj-8	22	38	other	other	ADJ
artofmedicineimsj-8	22	39	markers	marker	NOUN
artofmedicineimsj-8	22	40	of	of	ADP
artofmedicineimsj-8	22	41	kidney	kidney	NOUN
artofmedicineimsj-8	22	42	damage	damage	NOUN
artofmedicineimsj-8	22	43	[	[	X
artofmedicineimsj-8	22	44	13	13	NUM
artofmedicineimsj-8	22	45	]	]	PUNCT
artofmedicineimsj-8	22	46	.	.	PUNCT
artofmedicineimsj-8	23	1	the	the	DET
artofmedicineimsj-8	23	2	fundamental	fundamental	ADJ
artofmedicineimsj-8	23	3	difference	difference	NOUN
artofmedicineimsj-8	23	4	between	between	ADP
artofmedicineimsj-8	23	5	the	the	DET
artofmedicineimsj-8	23	6	concept	concept	NOUN
artofmedicineimsj-8	23	7	of	of	ADP
artofmedicineimsj-8	23	8	chronic	chronic	ADJ
artofmedicineimsj-8	23	9	kidney	kidney	NOUN
artofmedicineimsj-8	23	10	disease	disease	NOUN
artofmedicineimsj-8	23	11	and	and	CCONJ
artofmedicineimsj-8	23	12	chronic	chronic	ADJ
artofmedicineimsj-8	23	13	renal	renal	ADJ
artofmedicineimsj-8	23	14	failure	failure	NOUN
artofmedicineimsj-8	23	15	is	be	AUX
artofmedicineimsj-8	23	16	the	the	DET
artofmedicineimsj-8	23	17	inclusion	inclusion	NOUN
artofmedicineimsj-8	23	18	in	in	ADP
artofmedicineimsj-8	23	19	this	this	DET
artofmedicineimsj-8	23	20	category	category	NOUN
artofmedicineimsj-8	23	21	of	of	ADP
artofmedicineimsj-8	23	22	patients	patient	NOUN
artofmedicineimsj-8	23	23	,	,	PUNCT
artofmedicineimsj-8	23	24	including	include	VERB
artofmedicineimsj-8	23	25	those	those	PRON
artofmedicineimsj-8	23	26	with	with	ADP
artofmedicineimsj-8	23	27	a	a	DET
artofmedicineimsj-8	23	28	normal	normal	ADJ
artofmedicineimsj-8	23	29	functional	functional	ADJ
artofmedicineimsj-8	23	30	state	state	NOUN
artofmedicineimsj-8	23	31	of	of	ADP
artofmedicineimsj-8	23	32	the	the	DET
artofmedicineimsj-8	23	33	kidneys	kidney	NOUN
artofmedicineimsj-8	23	34	.	.	PUNCT
artofmedicineimsj-8	24	1	the	the	DET
artofmedicineimsj-8	24	2	concept	concept	NOUN
artofmedicineimsj-8	24	3	was	be	AUX
artofmedicineimsj-8	24	4	quickly	quickly	ADV
artofmedicineimsj-8	24	5	recognized	recognize	VERB
artofmedicineimsj-8	24	6	in	in	ADP
artofmedicineimsj-8	24	7	the	the	DET
artofmedicineimsj-8	24	8	world	world	NOUN
artofmedicineimsj-8	25	1	[	[	X
artofmedicineimsj-8	25	2	5	5	NUM
artofmedicineimsj-8	25	3	]	]	PUNCT
artofmedicineimsj-8	25	4	.	.	PUNCT
artofmedicineimsj-8	26	1	the	the	DET
artofmedicineimsj-8	26	2	prevalence	prevalence	NOUN
artofmedicineimsj-8	26	3	of	of	ADP
artofmedicineimsj-8	26	4	ckd	ckd	PROPN
artofmedicineimsj-8	26	5	in	in	ADP
artofmedicineimsj-8	26	6	romania	romania	PROPN
artofmedicineimsj-8	26	7	(	(	PUNCT
artofmedicineimsj-8	26	8	60	60	NUM
artofmedicineimsj-8	26	9	969	969	NUM
artofmedicineimsj-8	26	10	people	people	NOUN
artofmedicineimsj-8	26	11	aged	age	VERB
artofmedicineimsj-8	26	12	18	18	NUM
artofmedicineimsj-8	26	13	and	and	CCONJ
artofmedicineimsj-8	26	14	over	over	ADV
artofmedicineimsj-8	26	15	were	be	AUX
artofmedicineimsj-8	26	16	examined	examine	VERB
artofmedicineimsj-8	26	17	)	)	PUNCT
artofmedicineimsj-8	26	18	is	be	AUX
artofmedicineimsj-8	26	19	7	7	NUM
artofmedicineimsj-8	26	20	%	%	NOUN
artofmedicineimsj-8	26	21	[	[	X
artofmedicineimsj-8	26	22	8	8	NUM
artofmedicineimsj-8	26	23	]	]	PUNCT
artofmedicineimsj-8	26	24	,	,	PUNCT
artofmedicineimsj-8	26	25	in	in	ADP
artofmedicineimsj-8	26	26	the	the	DET
artofmedicineimsj-8	26	27	united	united	PROPN
artofmedicineimsj-8	26	28	states	states	PROPN
artofmedicineimsj-8	26	29	among	among	ADP
artofmedicineimsj-8	26	30	the	the	DET
artofmedicineimsj-8	26	31	population	population	NOUN
artofmedicineimsj-8	26	32	aged	age	VERB
artofmedicineimsj-8	26	33	20	20	NUM
artofmedicineimsj-8	26	34	and	and	CCONJ
artofmedicineimsj-8	26	35	over	over	ADP
artofmedicineimsj-8	26	36	12	12	NUM
artofmedicineimsj-8	26	37	%	%	NOUN
artofmedicineimsj-8	26	38	[	[	X
artofmedicineimsj-8	26	39	14	14	NUM
artofmedicineimsj-8	26	40	]	]	X
artofmedicineimsj-8	26	41	;	;	PUNCT
artofmedicineimsj-8	26	42	higher	high	ADJ
artofmedicineimsj-8	26	43	figures	figure	NOUN
artofmedicineimsj-8	26	44	are	be	AUX
artofmedicineimsj-8	26	45	also	also	ADV
artofmedicineimsj-8	26	46	given	give	VERB
artofmedicineimsj-8	26	47	,	,	PUNCT
artofmedicineimsj-8	26	48	in	in	ADP
artofmedicineimsj-8	26	49	particular	particular	ADJ
artofmedicineimsj-8	26	50	for	for	ADP
artofmedicineimsj-8	26	51	the	the	DET
artofmedicineimsj-8	26	52	united	united	PROPN
artofmedicineimsj-8	26	53	states	states	PROPN
artofmedicineimsj-8	26	54	,	,	PUNCT
artofmedicineimsj-8	26	55	which	which	PRON
artofmedicineimsj-8	26	56	largely	largely	ADV
artofmedicineimsj-8	26	57	depends	depend	VERB
artofmedicineimsj-8	26	58	on	on	ADP
artofmedicineimsj-8	26	59	the	the	DET
artofmedicineimsj-8	26	60	assessment	assessment	NOUN
artofmedicineimsj-8	26	61	methodology	methodology	NOUN
artofmedicineimsj-8	27	1	[	[	X
artofmedicineimsj-8	27	2	16	16	NUM
artofmedicineimsj-8	27	3	]	]	PUNCT
artofmedicineimsj-8	27	4	.	.	PUNCT
artofmedicineimsj-8	28	1	overall	overall	ADV
artofmedicineimsj-8	28	2	,	,	PUNCT
artofmedicineimsj-8	28	3	it	it	PRON
artofmedicineimsj-8	28	4	is	be	AUX
artofmedicineimsj-8	28	5	likely	likely	ADJ
artofmedicineimsj-8	28	6	that	that	SCONJ
artofmedicineimsj-8	28	7	about	about	ADV
artofmedicineimsj-8	28	8	10	10	NUM
artofmedicineimsj-8	28	9	%	%	NOUN
artofmedicineimsj-8	28	10	of	of	ADP
artofmedicineimsj-8	28	11	the	the	DET
artofmedicineimsj-8	28	12	world	world	NOUN
artofmedicineimsj-8	28	13	's	's	PART
artofmedicineimsj-8	28	14	adult	adult	NOUN
artofmedicineimsj-8	28	15	population	population	NOUN
artofmedicineimsj-8	28	16	has	have	VERB
artofmedicineimsj-8	28	17	ckd	ckd	PROPN
artofmedicineimsj-8	28	18	.	.	PUNCT
artofmedicineimsj-8	29	1	in	in	ADP
artofmedicineimsj-8	29	2	patients	patient	NOUN
artofmedicineimsj-8	29	3	with	with	ADP
artofmedicineimsj-8	29	4	arterial	arterial	ADJ
artofmedicineimsj-8	29	5	hypertension	hypertension	NOUN
artofmedicineimsj-8	29	6	,	,	PUNCT
artofmedicineimsj-8	29	7	the	the	DET
artofmedicineimsj-8	29	8	prevalence	prevalence	NOUN
artofmedicineimsj-8	29	9	of	of	ADP
artofmedicineimsj-8	29	10	ckd	ckd	PROPN
artofmedicineimsj-8	29	11	is	be	AUX
artofmedicineimsj-8	29	12	significantly	significantly	ADV
artofmedicineimsj-8	29	13	higher	high	ADJ
artofmedicineimsj-8	29	14	and	and	CCONJ
artofmedicineimsj-8	29	15	amounts	amount	VERB
artofmedicineimsj-8	29	16	to	to	ADP
artofmedicineimsj-8	29	17	27.5	27.5	NUM
artofmedicineimsj-8	29	18	%	%	NOUN
artofmedicineimsj-8	29	19	[	[	X
artofmedicineimsj-8	29	20	11	11	NUM
artofmedicineimsj-8	29	21	]	]	PUNCT
artofmedicineimsj-8	29	22	.	.	PUNCT
artofmedicineimsj-8	30	1	ckd	ckd	PROPN
artofmedicineimsj-8	30	2	occurs	occur	VERB
artofmedicineimsj-8	30	3	in	in	ADP
artofmedicineimsj-8	30	4	different	different	ADJ
artofmedicineimsj-8	30	5	age	age	NOUN
artofmedicineimsj-8	30	6	groups	group	NOUN
artofmedicineimsj-8	30	7	,	,	PUNCT
artofmedicineimsj-8	30	8	and	and	CCONJ
artofmedicineimsj-8	30	9	the	the	DET
artofmedicineimsj-8	30	10	frequency	frequency	NOUN
artofmedicineimsj-8	30	11	naturally	naturally	ADV
artofmedicineimsj-8	30	12	increases	increase	VERB
artofmedicineimsj-8	30	13	with	with	ADP
artofmedicineimsj-8	30	14	age	age	NOUN
artofmedicineimsj-8	30	15	.	.	PUNCT
artofmedicineimsj-8	31	1	thus	thus	ADV
artofmedicineimsj-8	31	2	,	,	PUNCT
artofmedicineimsj-8	31	3	in	in	ADP
artofmedicineimsj-8	31	4	the	the	DET
artofmedicineimsj-8	31	5	united	united	PROPN
artofmedicineimsj-8	31	6	states	states	PROPN
artofmedicineimsj-8	31	7	,	,	PUNCT
artofmedicineimsj-8	31	8	among	among	ADP
artofmedicineimsj-8	31	9	the	the	DET
artofmedicineimsj-8	31	10	population	population	NOUN
artofmedicineimsj-8	31	11	over	over	ADP
artofmedicineimsj-8	31	12	the	the	DET
artofmedicineimsj-8	31	13	age	age	NOUN
artofmedicineimsj-8	31	14	of	of	ADP
artofmedicineimsj-8	31	15	65	65	NUM
artofmedicineimsj-8	31	16	,	,	PUNCT
artofmedicineimsj-8	31	17	the	the	DET
artofmedicineimsj-8	31	18	frequency	frequency	NOUN
artofmedicineimsj-8	31	19	of	of	ADP
artofmedicineimsj-8	31	20	only	only	ADJ
artofmedicineimsj-8	31	21	stage	stage	PROPN
artofmedicineimsj-8	31	22	iii	iii	PROPN
artofmedicineimsj-8	31	23	ckd	ckd	PROPN
artofmedicineimsj-8	31	24	(	(	PUNCT
artofmedicineimsj-8	31	25	gfr	gfr	PROPN
artofmedicineimsj-8	31	26	30	30	NUM
artofmedicineimsj-8	31	27	-	-	SYM
artofmedicineimsj-8	31	28	59	59	NUM
artofmedicineimsj-8	31	29	ml	ml	NOUN
artofmedicineimsj-8	31	30	/	/	SYM
artofmedicineimsj-8	31	31	min	min	NOUN
artofmedicineimsj-8	31	32	per	per	ADP
artofmedicineimsj-8	31	33	1.73	1.73	NUM
artofmedicineimsj-8	31	34	m2	m2	NOUN
artofmedicineimsj-8	31	35	)	)	PUNCT
artofmedicineimsj-8	31	36	is	be	AUX
artofmedicineimsj-8	31	37	36.1	36.1	NUM
artofmedicineimsj-8	31	38	%	%	NOUN
artofmedicineimsj-8	31	39	;	;	PUNCT
artofmedicineimsj-8	31	40	while	while	SCONJ
artofmedicineimsj-8	31	41	38.6	38.6	NUM
artofmedicineimsj-8	31	42	%	%	NOUN
artofmedicineimsj-8	31	43	of	of	ADP
artofmedicineimsj-8	31	44	them	they	PRON
artofmedicineimsj-8	31	45	have	have	VERB
artofmedicineimsj-8	31	46	a	a	DET
artofmedicineimsj-8	31	47	serum	serum	NOUN
artofmedicineimsj-8	31	48	creatinine	creatinine	NOUN
artofmedicineimsj-8	31	49	level	level	NOUN
artofmedicineimsj-8	31	50	less	less	ADJ
artofmedicineimsj-8	31	51	than	than	ADP
artofmedicineimsj-8	31	52	1.2	1.2	NUM
artofmedicineimsj-8	31	53	mg	mg	PROPN
artofmedicineimsj-8	31	54	/	/	SYM
artofmedicineimsj-8	31	55	dl	dl	PROPN
artofmedicineimsj-8	32	1	(	(	PUNCT
artofmedicineimsj-8	32	2	<	<	X
artofmedicineimsj-8	32	3	106	106	NUM
artofmedicineimsj-8	32	4	μmol	μmol	PROPN
artofmedicineimsj-8	32	5	/	/	SYM
artofmedicineimsj-8	32	6	l	l	NOUN
artofmedicineimsj-8	32	7	)	)	PUNCT
artofmedicineimsj-8	33	1	[	[	X
artofmedicineimsj-8	33	2	12	12	NUM
artofmedicineimsj-8	33	3	]	]	PUNCT
artofmedicineimsj-8	33	4	,	,	PUNCT
artofmedicineimsj-8	33	5	which	which	PRON
artofmedicineimsj-8	33	6	confirms	confirm	VERB
artofmedicineimsj-8	33	7	the	the	DET
artofmedicineimsj-8	33	8	opinion	opinion	NOUN
artofmedicineimsj-8	33	9	about	about	ADP
artofmedicineimsj-8	33	10	the	the	DET
artofmedicineimsj-8	33	11	need	need	NOUN
artofmedicineimsj-8	33	12	to	to	PART
artofmedicineimsj-8	33	13	focus	focus	VERB
artofmedicineimsj-8	33	14	not	not	PART
artofmedicineimsj-8	33	15	on	on	ADP
artofmedicineimsj-8	33	16	the	the	DET
artofmedicineimsj-8	33	17	serum	serum	NOUN
artofmedicineimsj-8	33	18	creatinine	creatinine	NOUN
artofmedicineimsj-8	33	19	level	level	NOUN
artofmedicineimsj-8	33	20	,	,	PUNCT
artofmedicineimsj-8	33	21	but	but	CCONJ
artofmedicineimsj-8	33	22	on	on	ADP
artofmedicineimsj-8	33	23	gfr	gfr	NOUN
artofmedicineimsj-8	33	24	[	[	X
artofmedicineimsj-8	33	25	9	9	NUM
artofmedicineimsj-8	33	26	]	]	PUNCT
artofmedicineimsj-8	33	27	.	.	PUNCT
artofmedicineimsj-8	34	1	the	the	DET
artofmedicineimsj-8	34	2	leading	lead	VERB
artofmedicineimsj-8	34	3	causes	cause	NOUN
artofmedicineimsj-8	34	4	of	of	ADP
artofmedicineimsj-8	34	5	end	end	NOUN
artofmedicineimsj-8	34	6	-	-	PUNCT
artofmedicineimsj-8	34	7	stage	stage	NOUN
artofmedicineimsj-8	34	8	renal	renal	ADJ
artofmedicineimsj-8	34	9	failure	failure	NOUN
artofmedicineimsj-8	34	10	requiring	require	VERB
artofmedicineimsj-8	34	11	replacement	replacement	NOUN
artofmedicineimsj-8	34	12	therapy	therapy	NOUN
artofmedicineimsj-8	34	13	are	be	AUX
artofmedicineimsj-8	34	14	diabetes	diabetes	NOUN
artofmedicineimsj-8	34	15	mellitus	mellitus	NOUN
artofmedicineimsj-8	34	16	,	,	PUNCT
artofmedicineimsj-8	34	17	arterial	arterial	ADJ
artofmedicineimsj-8	34	18	hypertension	hypertension	NOUN
artofmedicineimsj-8	34	19	and	and	CCONJ
artofmedicineimsj-8	34	20	glomerulonephritis	glomerulonephritis	NOUN
artofmedicineimsj-8	34	21	[	[	X
artofmedicineimsj-8	34	22	10	10	NUM
artofmedicineimsj-8	34	23	]	]	PUNCT
artofmedicineimsj-8	34	24	.	.	PUNCT
artofmedicineimsj-8	35	1	the	the	DET
artofmedicineimsj-8	35	2	frequency	frequency	NOUN
artofmedicineimsj-8	35	3	of	of	ADP
artofmedicineimsj-8	35	4	development	development	NOUN
artofmedicineimsj-8	35	5	of	of	ADP
artofmedicineimsj-8	35	6	dn	dn	NOUN
artofmedicineimsj-8	35	7	closely	closely	ADV
artofmedicineimsj-8	35	8	depends	depend	VERB
artofmedicineimsj-8	35	9	on	on	ADP
artofmedicineimsj-8	35	10	the	the	DET
artofmedicineimsj-8	35	11	duration	duration	NOUN
artofmedicineimsj-8	35	12	of	of	ADP
artofmedicineimsj-8	35	13	the	the	DET
artofmedicineimsj-8	35	14	disease	disease	NOUN
artofmedicineimsj-8	35	15	,	,	PUNCT
artofmedicineimsj-8	35	16	with	with	ADP
artofmedicineimsj-8	35	17	a	a	DET
artofmedicineimsj-8	35	18	maximum	maximum	ADJ
artofmedicineimsj-8	35	19	peak	peak	NOUN
artofmedicineimsj-8	35	20	in	in	ADP
artofmedicineimsj-8	35	21	the	the	DET
artofmedicineimsj-8	35	22	period	period	NOUN
artofmedicineimsj-8	35	23	from	from	ADP
artofmedicineimsj-8	35	24	15	15	NUM
artofmedicineimsj-8	35	25	to	to	PART
artofmedicineimsj-8	35	26	20	20	NUM
artofmedicineimsj-8	35	27	years	year	NOUN
artofmedicineimsj-8	35	28	of	of	ADP
artofmedicineimsj-8	35	29	the	the	DET
artofmedicineimsj-8	35	30	course	course	NOUN
artofmedicineimsj-8	35	31	of	of	ADP
artofmedicineimsj-8	35	32	diabetes	diabetes	NOUN
artofmedicineimsj-8	35	33	.	.	PUNCT
artofmedicineimsj-8	36	1	according	accord	VERB
artofmedicineimsj-8	36	2	to	to	ADP
artofmedicineimsj-8	36	3	the	the	DET
artofmedicineimsj-8	36	4	state	state	NOUN
artofmedicineimsj-8	36	5	register	register	NOUN
artofmedicineimsj-8	36	6	of	of	ADP
artofmedicineimsj-8	36	7	dm	dm	PROPN
artofmedicineimsj-8	36	8	,	,	PUNCT
artofmedicineimsj-8	36	9	the	the	DET
artofmedicineimsj-8	36	10	prevalence	prevalence	NOUN
artofmedicineimsj-8	36	11	of	of	ADP
artofmedicineimsj-8	36	12	dn	dn	NOUN
artofmedicineimsj-8	36	13	is	be	AUX
artofmedicineimsj-8	36	14	on	on	ADP
artofmedicineimsj-8	36	15	average	average	ADJ
artofmedicineimsj-8	36	16	about	about	ADV
artofmedicineimsj-8	36	17	30	30	NUM
artofmedicineimsj-8	36	18	%	%	NOUN
artofmedicineimsj-8	36	19	in	in	ADP
artofmedicineimsj-8	36	20	type	type	NOUN
artofmedicineimsj-8	36	21	1	1	NUM
artofmedicineimsj-8	36	22	diabetes	diabetes	NOUN
artofmedicineimsj-8	36	23	(	(	PUNCT
artofmedicineimsj-8	36	24	t1	t1	NOUN
artofmedicineimsj-8	36	25	dm	dm	NOUN
artofmedicineimsj-8	36	26	)	)	PUNCT
artofmedicineimsj-8	36	27	and	and	CCONJ
artofmedicineimsj-8	36	28	type	type	NOUN
artofmedicineimsj-8	36	29	2	2	NUM
artofmedicineimsj-8	36	30	dm	dm	PROPN
artofmedicineimsj-8	36	31	(	(	PUNCT
artofmedicineimsj-8	36	32	t2	t2	NOUN
artofmedicineimsj-8	36	33	dm	dm	PROPN
artofmedicineimsj-8	36	34	)	)	PUNCT
artofmedicineimsj-8	37	1	[	[	X
artofmedicineimsj-8	37	2	1,2	1,2	NUM
artofmedicineimsj-8	37	3	]	]	PUNCT
artofmedicineimsj-8	37	4	.	.	PUNCT
artofmedicineimsj-8	38	1	according	accord	VERB
artofmedicineimsj-8	38	2	to	to	ADP
artofmedicineimsj-8	38	3	the	the	DET
artofmedicineimsj-8	38	4	literature	literature	NOUN
artofmedicineimsj-8	38	5	,	,	PUNCT
artofmedicineimsj-8	38	6	the	the	DET
artofmedicineimsj-8	38	7	earliest	early	ADJ
artofmedicineimsj-8	38	8	laboratory	laboratory	NOUN
artofmedicineimsj-8	38	9	marker	marker	NOUN
artofmedicineimsj-8	38	10	of	of	ADP
artofmedicineimsj-8	38	11	renal	renal	ADJ
artofmedicineimsj-8	38	12	dysfunction	dysfunction	NOUN
artofmedicineimsj-8	38	13	is	be	AUX
artofmedicineimsj-8	38	14	hyperfiltration	hyperfiltration	NOUN
artofmedicineimsj-8	38	15	,	,	PUNCT
artofmedicineimsj-8	38	16	i.e.	i.e.	X
artofmedicineimsj-8	38	17	increased	increase	VERB
artofmedicineimsj-8	38	18	glomerular	glomerular	ADJ
artofmedicineimsj-8	38	19	filtration	filtration	NOUN
artofmedicineimsj-8	38	20	rate	rate	NOUN
artofmedicineimsj-8	38	21	(	(	PUNCT
artofmedicineimsj-8	38	22	gfr	gfr	NOUN
artofmedicineimsj-8	38	23	)	)	PUNCT
artofmedicineimsj-8	38	24	.	.	PUNCT
artofmedicineimsj-8	39	1	it	it	PRON
artofmedicineimsj-8	39	2	develops	develop	VERB
artofmedicineimsj-8	39	3	in	in	ADP
artofmedicineimsj-8	39	4	the	the	DET
artofmedicineimsj-8	39	5	first	first	ADJ
artofmedicineimsj-8	39	6	months	month	NOUN
artofmedicineimsj-8	39	7	after	after	ADP
artofmedicineimsj-8	39	8	the	the	DET
artofmedicineimsj-8	39	9	onset	onset	NOUN
artofmedicineimsj-8	39	10	of	of	ADP
artofmedicineimsj-8	39	11	diabetes	diabetes	NOUN
artofmedicineimsj-8	39	12	and	and	CCONJ
artofmedicineimsj-8	39	13	can	can	AUX
artofmedicineimsj-8	39	14	persist	persist	VERB
artofmedicineimsj-8	39	15	for	for	ADP
artofmedicineimsj-8	39	16	several	several	ADJ
artofmedicineimsj-8	39	17	years	year	NOUN
artofmedicineimsj-8	39	18	.	.	PUNCT
artofmedicineimsj-8	40	1	in	in	ADP
artofmedicineimsj-8	40	2	subsequent	subsequent	ADJ
artofmedicineimsj-8	40	3	years	year	NOUN
artofmedicineimsj-8	40	4	,	,	PUNCT
artofmedicineimsj-8	40	5	art	art	NOUN
artofmedicineimsj-8	40	6	of	of	ADP
artofmedicineimsj-8	40	7	medicine	medicine	NOUN
artofmedicineimsj-8	40	8	international	international	ADJ
artofmedicineimsj-8	40	9	medical	medical	ADJ
artofmedicineimsj-8	40	10	scientific	scientific	ADJ
artofmedicineimsj-8	40	11	journal	journal	NOUN
artofmedicineimsj-8	40	12	volume-1	volume-1	PROPN
artofmedicineimsj-8	40	13	issue-1	issue-1	PROPN
artofmedicineimsj-8	40	14	6	6	NUM
artofmedicineimsj-8	40	15	with	with	ADP
artofmedicineimsj-8	40	16	persisting	persist	VERB
artofmedicineimsj-8	40	17	hyperglycemia	hyperglycemia	NOUN
artofmedicineimsj-8	40	18	,	,	PUNCT
artofmedicineimsj-8	40	19	structural	structural	ADJ
artofmedicineimsj-8	40	20	restructuring	restructuring	NOUN
artofmedicineimsj-8	40	21	of	of	ADP
artofmedicineimsj-8	40	22	the	the	DET
artofmedicineimsj-8	40	23	kidneys	kidney	NOUN
artofmedicineimsj-8	40	24	begins	begin	VERB
artofmedicineimsj-8	40	25	:	:	PUNCT
artofmedicineimsj-8	40	26	the	the	DET
artofmedicineimsj-8	40	27	basement	basement	NOUN
artofmedicineimsj-8	40	28	membrane	membrane	NOUN
artofmedicineimsj-8	40	29	of	of	ADP
artofmedicineimsj-8	40	30	the	the	DET
artofmedicineimsj-8	40	31	glomeruli	glomeruli	NOUN
artofmedicineimsj-8	40	32	(	(	PUNCT
artofmedicineimsj-8	40	33	bmc	bmc	NOUN
artofmedicineimsj-8	40	34	)	)	PUNCT
artofmedicineimsj-8	40	35	thickens	thicken	NOUN
artofmedicineimsj-8	40	36	,	,	PUNCT
artofmedicineimsj-8	40	37	the	the	DET
artofmedicineimsj-8	40	38	volume	volume	NOUN
artofmedicineimsj-8	40	39	of	of	ADP
artofmedicineimsj-8	40	40	the	the	DET
artofmedicineimsj-8	40	41	mesangium	mesangium	NOUN
artofmedicineimsj-8	40	42	increases	increase	NOUN
artofmedicineimsj-8	40	43	.	.	PUNCT
artofmedicineimsj-8	41	1	scientific	scientific	ADJ
artofmedicineimsj-8	41	2	studies	study	NOUN
artofmedicineimsj-8	41	3	have	have	AUX
artofmedicineimsj-8	41	4	shown	show	VERB
artofmedicineimsj-8	41	5	that	that	SCONJ
artofmedicineimsj-8	41	6	the	the	DET
artofmedicineimsj-8	41	7	first	first	ADJ
artofmedicineimsj-8	41	8	changes	change	NOUN
artofmedicineimsj-8	41	9	in	in	ADP
artofmedicineimsj-8	41	10	the	the	DET
artofmedicineimsj-8	41	11	mesangium	mesangium	NOUN
artofmedicineimsj-8	41	12	appear	appear	VERB
artofmedicineimsj-8	41	13	in	in	ADP
artofmedicineimsj-8	41	14	the	the	DET
artofmedicineimsj-8	41	15	area	area	NOUN
artofmedicineimsj-8	41	16	of	of	ADP
artofmedicineimsj-8	41	17	the	the	DET
artofmedicineimsj-8	41	18	glomerulus	glomerulus	NOUN
artofmedicineimsj-8	41	19	knob	knob	NOUN
artofmedicineimsj-8	41	20	,	,	PUNCT
artofmedicineimsj-8	41	21	where	where	SCONJ
artofmedicineimsj-8	41	22	the	the	DET
artofmedicineimsj-8	41	23	maximum	maximum	ADJ
artofmedicineimsj-8	41	24	gradient	gradient	NOUN
artofmedicineimsj-8	41	25	of	of	ADP
artofmedicineimsj-8	41	26	intraglomerular	intraglomerular	ADJ
artofmedicineimsj-8	41	27	hydrostatic	hydrostatic	ADJ
artofmedicineimsj-8	41	28	pressure	pressure	NOUN
artofmedicineimsj-8	41	29	is	be	AUX
artofmedicineimsj-8	41	30	formed	form	VERB
artofmedicineimsj-8	41	31	[	[	X
artofmedicineimsj-8	41	32	6	6	NUM
artofmedicineimsj-8	41	33	]	]	PUNCT
artofmedicineimsj-8	41	34	.	.	PUNCT
artofmedicineimsj-8	42	1	as	as	ADP
artofmedicineimsj-8	42	2	a	a	DET
artofmedicineimsj-8	42	3	result	result	NOUN
artofmedicineimsj-8	42	4	,	,	PUNCT
artofmedicineimsj-8	42	5	the	the	DET
artofmedicineimsj-8	42	6	integrity	integrity	NOUN
artofmedicineimsj-8	42	7	of	of	ADP
artofmedicineimsj-8	42	8	the	the	DET
artofmedicineimsj-8	42	9	bmc	bmc	NOUN
artofmedicineimsj-8	42	10	is	be	AUX
artofmedicineimsj-8	42	11	disrupted	disrupt	VERB
artofmedicineimsj-8	42	12	and	and	CCONJ
artofmedicineimsj-8	42	13	microalbuminuria	microalbuminuria	PROPN
artofmedicineimsj-8	42	14	(	(	PUNCT
artofmedicineimsj-8	42	15	mau	mau	PROPN
artofmedicineimsj-8	42	16	)	)	PUNCT
artofmedicineimsj-8	42	17	occurs	occur	VERB
artofmedicineimsj-8	42	18	the	the	DET
artofmedicineimsj-8	42	19	first	first	ADJ
artofmedicineimsj-8	42	20	laboratory	laboratory	NOUN
artofmedicineimsj-8	42	21	marker	marker	NOUN
artofmedicineimsj-8	42	22	of	of	ADP
artofmedicineimsj-8	42	23	diabetic	diabetic	ADJ
artofmedicineimsj-8	42	24	nephropathy	nephropathy	NOUN
artofmedicineimsj-8	42	25	.	.	PUNCT
artofmedicineimsj-8	43	1	in	in	ADP
artofmedicineimsj-8	43	2	the	the	DET
artofmedicineimsj-8	43	3	future	future	NOUN
artofmedicineimsj-8	43	4	,	,	PUNCT
artofmedicineimsj-8	43	5	the	the	DET
artofmedicineimsj-8	43	6	accumulation	accumulation	NOUN
artofmedicineimsj-8	43	7	of	of	ADP
artofmedicineimsj-8	43	8	remarkable	remarkable	ADJ
artofmedicineimsj-8	43	9	structural	structural	ADJ
artofmedicineimsj-8	43	10	changes	change	NOUN
artofmedicineimsj-8	43	11	leads	lead	VERB
artofmedicineimsj-8	43	12	to	to	ADP
artofmedicineimsj-8	43	13	the	the	DET
artofmedicineimsj-8	43	14	formation	formation	NOUN
artofmedicineimsj-8	43	15	diffuse	diffuse	NOUN
artofmedicineimsj-8	43	16	glomerulosclerosis	glomerulosclerosis	NOUN
artofmedicineimsj-8	43	17	,	,	PUNCT
artofmedicineimsj-8	43	18	which	which	PRON
artofmedicineimsj-8	43	19	is	be	AUX
artofmedicineimsj-8	43	20	usually	usually	ADV
artofmedicineimsj-8	43	21	accompanied	accompany	VERB
artofmedicineimsj-8	43	22	by	by	ADP
artofmedicineimsj-8	43	23	the	the	DET
artofmedicineimsj-8	43	24	development	development	NOUN
artofmedicineimsj-8	43	25	of	of	ADP
artofmedicineimsj-8	43	26	proteinuria	proteinuria	NOUN
artofmedicineimsj-8	43	27	and	and	CCONJ
artofmedicineimsj-8	43	28	a	a	DET
artofmedicineimsj-8	43	29	decrease	decrease	NOUN
artofmedicineimsj-8	43	30	in	in	ADP
artofmedicineimsj-8	43	31	gfr	gfr	PROPN
artofmedicineimsj-8	43	32	.	.	PUNCT
artofmedicineimsj-8	44	1	at	at	ADP
artofmedicineimsj-8	44	2	the	the	DET
artofmedicineimsj-8	44	3	final	final	ADJ
artofmedicineimsj-8	44	4	stage	stage	NOUN
artofmedicineimsj-8	44	5	of	of	ADP
artofmedicineimsj-8	44	6	structural	structural	ADJ
artofmedicineimsj-8	44	7	changes	change	NOUN
artofmedicineimsj-8	44	8	,	,	PUNCT
artofmedicineimsj-8	44	9	nodular	nodular	ADJ
artofmedicineimsj-8	44	10	glomerulosclerosis	glomerulosclerosis	NOUN
artofmedicineimsj-8	44	11	is	be	AUX
artofmedicineimsj-8	44	12	formed	form	VERB
artofmedicineimsj-8	44	13	,	,	PUNCT
artofmedicineimsj-8	44	14	the	the	DET
artofmedicineimsj-8	44	15	clinical	clinical	ADJ
artofmedicineimsj-8	44	16	equivalent	equivalent	NOUN
artofmedicineimsj-8	44	17	of	of	ADP
artofmedicineimsj-8	44	18	which	which	PRON
artofmedicineimsj-8	44	19	is	be	AUX
artofmedicineimsj-8	44	20	decreased	decrease	VERB
artofmedicineimsj-8	44	21	gfr	gfr	PROPN
artofmedicineimsj-8	44	22	,	,	PUNCT
artofmedicineimsj-8	44	23	azotemia	azotemia	NOUN
artofmedicineimsj-8	45	1	[	[	X
artofmedicineimsj-8	45	2	7	7	NUM
artofmedicineimsj-8	45	3	]	]	PUNCT
artofmedicineimsj-8	45	4	.	.	PUNCT
artofmedicineimsj-8	46	1	gfr	gfr	PROPN
artofmedicineimsj-8	46	2	takes	take	VERB
artofmedicineimsj-8	46	3	on	on	ADP
artofmedicineimsj-8	46	4	a	a	DET
artofmedicineimsj-8	46	5	progressive	progressive	ADJ
artofmedicineimsj-8	46	6	course	course	NOUN
artofmedicineimsj-8	46	7	4	4	NUM
artofmedicineimsj-8	46	8	-	-	SYM
artofmedicineimsj-8	46	9	5	5	NUM
artofmedicineimsj-8	46	10	years	year	NOUN
artofmedicineimsj-8	46	11	after	after	ADP
artofmedicineimsj-8	46	12	the	the	DET
artofmedicineimsj-8	46	13	onset	onset	NOUN
artofmedicineimsj-8	46	14	of	of	ADP
artofmedicineimsj-8	46	15	chronic	chronic	ADJ
artofmedicineimsj-8	46	16	kidney	kidney	NOUN
artofmedicineimsj-8	46	17	disease	disease	NOUN
artofmedicineimsj-8	46	18	(	(	PUNCT
artofmedicineimsj-8	46	19	ckd	ckd	NOUN
artofmedicineimsj-8	46	20	)	)	PUNCT
artofmedicineimsj-8	46	21	with	with	ADP
artofmedicineimsj-8	46	22	a	a	DET
artofmedicineimsj-8	46	23	decrease	decrease	NOUN
artofmedicineimsj-8	46	24	in	in	ADP
artofmedicineimsj-8	46	25	gfr	gfr	NOUN
artofmedicineimsj-8	46	26	to	to	ADP
artofmedicineimsj-8	46	27	5.9	5.9	NUM
artofmedicineimsj-8	46	28	-	-	SYM
artofmedicineimsj-8	46	29	6.2	6.2	NUM
artofmedicineimsj-8	46	30	ml	ml	NOUN
artofmedicineimsj-8	46	31	/	/	SYM
artofmedicineimsj-8	46	32	min	min	PROPN
artofmedicineimsj-8	46	33	/	/	SYM
artofmedicineimsj-8	46	34	year	year	NOUN
artofmedicineimsj-8	46	35	.	.	PUNCT
artofmedicineimsj-8	47	1	during	during	ADP
artofmedicineimsj-8	47	2	the	the	DET
artofmedicineimsj-8	47	3	first	first	ADJ
artofmedicineimsj-8	47	4	3	3	NUM
artofmedicineimsj-8	47	5	years	year	NOUN
artofmedicineimsj-8	47	6	,	,	PUNCT
artofmedicineimsj-8	47	7	the	the	DET
artofmedicineimsj-8	47	8	rate	rate	NOUN
artofmedicineimsj-8	47	9	of	of	ADP
artofmedicineimsj-8	47	10	gfr	gfr	NOUN
artofmedicineimsj-8	47	11	decline	decline	NOUN
artofmedicineimsj-8	47	12	remains	remain	VERB
artofmedicineimsj-8	47	13	significantly	significantly	ADV
artofmedicineimsj-8	47	14	lower	low	ADJ
artofmedicineimsj-8	47	15	(	(	PUNCT
artofmedicineimsj-8	47	16	gfr	gfr	NOUN
artofmedicineimsj-8	47	17	2.8	2.8	NUM
artofmedicineimsj-8	47	18	-	-	SYM
artofmedicineimsj-8	47	19	3.4	3.4	NUM
artofmedicineimsj-8	47	20	ml	ml	NOUN
artofmedicineimsj-8	47	21	/	/	SYM
artofmedicineimsj-8	47	22	min	min	PROPN
artofmedicineimsj-8	47	23	/	/	SYM
artofmedicineimsj-8	47	24	year	year	NOUN
artofmedicineimsj-8	47	25	,	,	PUNCT
artofmedicineimsj-8	47	26	p	p	X
artofmedicineimsj-8	47	27	<	<	NOUN
artofmedicineimsj-8	47	28	0.05	0.05	NUM
artofmedicineimsj-8	47	29	)	)	PUNCT
artofmedicineimsj-8	47	30	.	.	PUNCT
artofmedicineimsj-8	48	1	in	in	ADP
artofmedicineimsj-8	48	2	patients	patient	NOUN
artofmedicineimsj-8	48	3	with	with	ADP
artofmedicineimsj-8	48	4	ckd	ckd	PROPN
artofmedicineimsj-8	48	5	,	,	PUNCT
artofmedicineimsj-8	48	6	direct	direct	ADJ
artofmedicineimsj-8	48	7	correlations	correlation	NOUN
artofmedicineimsj-8	48	8	were	be	AUX
artofmedicineimsj-8	48	9	established	establish	VERB
artofmedicineimsj-8	48	10	between	between	ADP
artofmedicineimsj-8	48	11	indicators	indicator	NOUN
artofmedicineimsj-8	48	12	of	of	ADP
artofmedicineimsj-8	48	13	tubular	tubular	ADJ
artofmedicineimsj-8	48	14	dysfunction	dysfunction	NOUN
artofmedicineimsj-8	48	15	and	and	CCONJ
artofmedicineimsj-8	48	16	the	the	DET
artofmedicineimsj-8	48	17	main	main	ADJ
artofmedicineimsj-8	48	18	parameters	parameter	NOUN
artofmedicineimsj-8	48	19	of	of	ADP
artofmedicineimsj-8	48	20	disease	disease	NOUN
artofmedicineimsj-8	48	21	progression	progression	PROPN
artofmedicineimsj-8	48	22	gfr	gfr	PROPN
artofmedicineimsj-8	48	23	,	,	PUNCT
artofmedicineimsj-8	48	24	daily	daily	ADJ
artofmedicineimsj-8	48	25	proteinuria	proteinuria	NOUN
artofmedicineimsj-8	48	26	,	,	PUNCT
artofmedicineimsj-8	48	27	and	and	CCONJ
artofmedicineimsj-8	48	28	serum	serum	NOUN
artofmedicineimsj-8	48	29	creatinine	creatinine	NOUN
artofmedicineimsj-8	48	30	levels	level	NOUN
artofmedicineimsj-8	48	31	.	.	PUNCT
artofmedicineimsj-8	49	1	correlation	correlation	NOUN
artofmedicineimsj-8	49	2	analysis	analysis	NOUN
artofmedicineimsj-8	49	3	revealed	reveal	VERB
artofmedicineimsj-8	49	4	a	a	DET
artofmedicineimsj-8	49	5	high	high	ADJ
artofmedicineimsj-8	49	6	inverse	inverse	NOUN
artofmedicineimsj-8	49	7	degree	degree	NOUN
artofmedicineimsj-8	49	8	of	of	ADP
artofmedicineimsj-8	49	9	correlation	correlation	NOUN
artofmedicineimsj-8	49	10	between	between	ADP
artofmedicineimsj-8	49	11	creatinine	creatinine	NOUN
artofmedicineimsj-8	49	12	and	and	CCONJ
artofmedicineimsj-8	49	13	total	total	ADJ
artofmedicineimsj-8	49	14	protein	protein	NOUN
artofmedicineimsj-8	49	15	(	(	PUNCT
artofmedicineimsj-8	49	16	p	p	X
artofmedicineimsj-8	49	17	<	<	X
artofmedicineimsj-8	49	18	0.05	0.05	NUM
artofmedicineimsj-8	49	19	)	)	PUNCT
artofmedicineimsj-8	49	20	,	,	PUNCT
artofmedicineimsj-8	49	21	urea	urea	NOUN
artofmedicineimsj-8	49	22	and	and	CCONJ
artofmedicineimsj-8	49	23	total	total	ADJ
artofmedicineimsj-8	49	24	protein	protein	NOUN
artofmedicineimsj-8	49	25	;	;	PUNCT
artofmedicineimsj-8	49	26	as	as	ADV
artofmedicineimsj-8	49	27	well	well	ADV
artofmedicineimsj-8	49	28	as	as	ADP
artofmedicineimsj-8	49	29	creatinine	creatinine	NOUN
artofmedicineimsj-8	49	30	,	,	PUNCT
artofmedicineimsj-8	49	31	urea	urea	NOUN
artofmedicineimsj-8	49	32	and	and	CCONJ
artofmedicineimsj-8	49	33	serum	serum	NOUN
artofmedicineimsj-8	49	34	albumin	albumin	NOUN
artofmedicineimsj-8	49	35	[	[	X
artofmedicineimsj-8	49	36	3	3	NUM
artofmedicineimsj-8	49	37	]	]	PUNCT
artofmedicineimsj-8	49	38	.	.	PUNCT
artofmedicineimsj-8	50	1	diabetic	diabetic	ADJ
artofmedicineimsj-8	50	2	nephropathy	nephropathy	NOUN
artofmedicineimsj-8	50	3	develops	develop	VERB
artofmedicineimsj-8	50	4	for	for	ADP
artofmedicineimsj-8	50	5	a	a	DET
artofmedicineimsj-8	50	6	wide	wide	ADJ
artofmedicineimsj-8	50	7	variety	variety	NOUN
artofmedicineimsj-8	50	8	of	of	ADP
artofmedicineimsj-8	50	9	reasons	reason	NOUN
artofmedicineimsj-8	50	10	.	.	PUNCT
artofmedicineimsj-8	51	1	but	but	CCONJ
artofmedicineimsj-8	51	2	of	of	ADP
artofmedicineimsj-8	51	3	all	all	DET
artofmedicineimsj-8	51	4	the	the	DET
artofmedicineimsj-8	51	5	variety	variety	NOUN
artofmedicineimsj-8	51	6	of	of	ADP
artofmedicineimsj-8	51	7	mechanisms	mechanism	NOUN
artofmedicineimsj-8	51	8	of	of	ADP
artofmedicineimsj-8	51	9	development	development	NOUN
artofmedicineimsj-8	51	10	of	of	ADP
artofmedicineimsj-8	51	11	dn	dn	PROPN
artofmedicineimsj-8	51	12	,	,	PUNCT
artofmedicineimsj-8	51	13	the	the	DET
artofmedicineimsj-8	51	14	most	most	ADV
artofmedicineimsj-8	51	15	studied	study	VERB
artofmedicineimsj-8	51	16	and	and	CCONJ
artofmedicineimsj-8	51	17	proven	prove	VERB
artofmedicineimsj-8	51	18	are	be	AUX
artofmedicineimsj-8	51	19	:	:	PUNCT
artofmedicineimsj-8	51	20	metabolic	metabolic	NOUN
artofmedicineimsj-8	51	21	(	(	PUNCT
artofmedicineimsj-8	51	22	hyperglycemia	hyperglycemia	NOUN
artofmedicineimsj-8	51	23	,	,	PUNCT
artofmedicineimsj-8	51	24	hyperlipidemia	hyperlipidemia	NOUN
artofmedicineimsj-8	51	25	)	)	PUNCT
artofmedicineimsj-8	51	26	and	and	CCONJ
artofmedicineimsj-8	51	27	hemodynamic	hemodynamic	ADJ
artofmedicineimsj-8	51	28	(	(	PUNCT
artofmedicineimsj-8	51	29	activation	activation	NOUN
artofmedicineimsj-8	51	30	of	of	ADP
artofmedicineimsj-8	51	31	the	the	DET
artofmedicineimsj-8	51	32	renin	renin	ADJ
artofmedicineimsj-8	51	33	-	-	PUNCT
artofmedicineimsj-8	51	34	angiotensin	angiotensin	NOUN
artofmedicineimsj-8	51	35	-	-	PUNCT
artofmedicineimsj-8	51	36	aldosterone	aldosterone	NOUN
artofmedicineimsj-8	51	37	system	system	NOUN
artofmedicineimsj-8	51	38	,	,	PUNCT
artofmedicineimsj-8	51	39	renal	renal	ADJ
artofmedicineimsj-8	51	40	arterial	arterial	NOUN
artofmedicineimsj-8	51	41	hypertension	hypertension	NOUN
artofmedicineimsj-8	51	42	)	)	PUNCT
artofmedicineimsj-8	51	43	.	.	PUNCT
artofmedicineimsj-8	52	1	according	accord	VERB
artofmedicineimsj-8	52	2	to	to	ADP
artofmedicineimsj-8	52	3	the	the	DET
artofmedicineimsj-8	52	4	literature	literature	NOUN
artofmedicineimsj-8	52	5	and	and	CCONJ
artofmedicineimsj-8	52	6	numerous	numerous	ADJ
artofmedicineimsj-8	52	7	studies	study	NOUN
artofmedicineimsj-8	52	8	,	,	PUNCT
artofmedicineimsj-8	52	9	it	it	PRON
artofmedicineimsj-8	52	10	was	be	AUX
artofmedicineimsj-8	52	11	found	find	VERB
artofmedicineimsj-8	52	12	that	that	SCONJ
artofmedicineimsj-8	52	13	blockers	blocker	NOUN
artofmedicineimsj-8	52	14	of	of	ADP
artofmedicineimsj-8	52	15	the	the	DET
artofmedicineimsj-8	52	16	renin	renin	ADJ
artofmedicineimsj-8	52	17	-	-	PUNCT
artofmedicineimsj-8	52	18	angiotensin	angiotensin	NOUN
artofmedicineimsj-8	52	19	-	-	PUNCT
artofmedicineimsj-8	52	20	aldosterone	aldosterone	NOUN
artofmedicineimsj-8	52	21	system	system	NOUN
artofmedicineimsj-8	52	22	are	be	AUX
artofmedicineimsj-8	52	23	more	more	ADV
artofmedicineimsj-8	52	24	effective	effective	ADJ
artofmedicineimsj-8	52	25	in	in	ADP
artofmedicineimsj-8	52	26	reducing	reduce	VERB
artofmedicineimsj-8	52	27	albuminuria	albuminuria	NOUN
artofmedicineimsj-8	52	28	compared	compare	VERB
artofmedicineimsj-8	52	29	to	to	ADP
artofmedicineimsj-8	52	30	placebo	placebo	NOUN
artofmedicineimsj-8	52	31	or	or	CCONJ
artofmedicineimsj-8	52	32	other	other	ADJ
artofmedicineimsj-8	52	33	antihypertensive	antihypertensive	ADJ
artofmedicineimsj-8	52	34	drugs	drug	NOUN
artofmedicineimsj-8	52	35	in	in	ADP
artofmedicineimsj-8	52	36	patients	patient	NOUN
artofmedicineimsj-8	52	37	with	with	ADP
artofmedicineimsj-8	52	38	diabetic	diabetic	ADJ
artofmedicineimsj-8	52	39	and	and	CCONJ
artofmedicineimsj-8	52	40	nondiabetic	nondiabetic	ADJ
artofmedicineimsj-8	52	41	nephropathy	nephropathy	NOUN
artofmedicineimsj-8	52	42	,	,	PUNCT
artofmedicineimsj-8	52	43	cvd	cvd	PROPN
artofmedicineimsj-8	52	44	,	,	PUNCT
artofmedicineimsj-8	52	45	and	and	CCONJ
artofmedicineimsj-8	52	46	are	be	AUX
artofmedicineimsj-8	52	47	also	also	ADV
artofmedicineimsj-8	52	48	effective	effective	ADJ
artofmedicineimsj-8	52	49	in	in	ADP
artofmedicineimsj-8	52	50	preventing	prevent	VERB
artofmedicineimsj-8	52	51	microalbuminuria	microalbuminuria	NOUN
artofmedicineimsj-8	52	52	.	.	PUNCT
artofmedicineimsj-8	53	1	in	in	ADP
artofmedicineimsj-8	53	2	recent	recent	ADJ
artofmedicineimsj-8	53	3	years	year	NOUN
artofmedicineimsj-8	53	4	,	,	PUNCT
artofmedicineimsj-8	53	5	natriuretic	natriuretic	ADJ
artofmedicineimsj-8	53	6	peptides	peptide	NOUN
artofmedicineimsj-8	53	7	have	have	AUX
artofmedicineimsj-8	53	8	also	also	ADV
artofmedicineimsj-8	53	9	been	be	AUX
artofmedicineimsj-8	53	10	used	use	VERB
artofmedicineimsj-8	53	11	in	in	ADP
artofmedicineimsj-8	53	12	experimental	experimental	ADJ
artofmedicineimsj-8	53	13	studies	study	NOUN
artofmedicineimsj-8	53	14	to	to	PART
artofmedicineimsj-8	53	15	achieve	achieve	VERB
artofmedicineimsj-8	53	16	the	the	DET
artofmedicineimsj-8	53	17	same	same	ADJ
artofmedicineimsj-8	53	18	results	result	NOUN
artofmedicineimsj-8	53	19	.	.	PUNCT
artofmedicineimsj-8	54	1	they	they	PRON
artofmedicineimsj-8	54	2	play	play	VERB
artofmedicineimsj-8	54	3	an	an	DET
artofmedicineimsj-8	54	4	important	important	ADJ
artofmedicineimsj-8	54	5	role	role	NOUN
artofmedicineimsj-8	54	6	in	in	ADP
artofmedicineimsj-8	54	7	the	the	DET
artofmedicineimsj-8	54	8	activation	activation	NOUN
artofmedicineimsj-8	54	9	response	response	NOUN
artofmedicineimsj-8	54	10	of	of	ADP
artofmedicineimsj-8	54	11	the	the	DET
artofmedicineimsj-8	54	12	renin	renin	ADJ
artofmedicineimsj-8	54	13	-	-	PUNCT
artofmedicineimsj-8	54	14	angiotensin	angiotensin	NOUN
artofmedicineimsj-8	54	15	-	-	PUNCT
artofmedicineimsj-8	54	16	aldosterone	aldosterone	NOUN
artofmedicineimsj-8	54	17	system	system	NOUN
artofmedicineimsj-8	54	18	.	.	PUNCT
artofmedicineimsj-8	55	1	natriuretic	natriuretic	ADJ
artofmedicineimsj-8	55	2	peptides	peptide	NOUN
artofmedicineimsj-8	55	3	are	be	AUX
artofmedicineimsj-8	55	4	physiological	physiological	ADJ
artofmedicineimsj-8	55	5	antagonists	antagonist	NOUN
artofmedicineimsj-8	55	6	of	of	ADP
artofmedicineimsj-8	55	7	angiotensin	angiotensin	PROPN
artofmedicineimsj-8	55	8	ii	ii	PROPN
artofmedicineimsj-8	55	9	in	in	ADP
artofmedicineimsj-8	55	10	relation	relation	NOUN
artofmedicineimsj-8	55	11	to	to	ADP
artofmedicineimsj-8	55	12	stimulating	stimulate	VERB
artofmedicineimsj-8	55	13	the	the	DET
artofmedicineimsj-8	55	14	secretion	secretion	NOUN
artofmedicineimsj-8	55	15	of	of	ADP
artofmedicineimsj-8	55	16	aldosterone	aldosterone	NOUN
artofmedicineimsj-8	55	17	,	,	PUNCT
artofmedicineimsj-8	55	18	enhancing	enhance	VERB
artofmedicineimsj-8	55	19	sodium	sodium	NOUN
artofmedicineimsj-8	55	20	reabsorption	reabsorption	NOUN
artofmedicineimsj-8	55	21	and	and	CCONJ
artofmedicineimsj-8	55	22	increasing	increase	VERB
artofmedicineimsj-8	55	23	vascular	vascular	ADJ
artofmedicineimsj-8	55	24	tone	tone	NOUN
artofmedicineimsj-8	55	25	.	.	PUNCT
artofmedicineimsj-8	56	1	besides	besides	SCONJ
artofmedicineimsj-8	56	2	,	,	PUNCT
artofmedicineimsj-8	56	3	atrial	atrial	ADJ
artofmedicineimsj-8	56	4	natriuretic	natriuretic	ADJ
artofmedicineimsj-8	56	5	peptide	peptide	NOUN
artofmedicineimsj-8	56	6	(	(	PUNCT
artofmedicineimsj-8	56	7	anp	anp	PROPN
artofmedicineimsj-8	56	8	)	)	PUNCT
artofmedicineimsj-8	56	9	enhances	enhance	VERB
artofmedicineimsj-8	56	10	venous	venous	ADJ
artofmedicineimsj-8	56	11	permeability	permeability	NOUN
artofmedicineimsj-8	56	12	,	,	PUNCT
artofmedicineimsj-8	56	13	causing	cause	VERB
artofmedicineimsj-8	56	14	the	the	DET
artofmedicineimsj-8	56	15	liquid	liquid	ADJ
artofmedicineimsj-8	56	16	portion	portion	NOUN
artofmedicineimsj-8	56	17	of	of	ADP
artofmedicineimsj-8	56	18	plasma	plasma	NOUN
artofmedicineimsj-8	56	19	to	to	PART
artofmedicineimsj-8	56	20	move	move	VERB
artofmedicineimsj-8	56	21	into	into	ADP
artofmedicineimsj-8	56	22	the	the	DET
artofmedicineimsj-8	56	23	extravascular	extravascular	ADJ
artofmedicineimsj-8	56	24	space	space	NOUN
artofmedicineimsj-8	56	25	(	(	PUNCT
artofmedicineimsj-8	56	26	reduced	reduce	VERB
artofmedicineimsj-8	56	27	preload	preload	NOUN
artofmedicineimsj-8	56	28	)	)	PUNCT
artofmedicineimsj-8	56	29	and	and	CCONJ
artofmedicineimsj-8	56	30	reduce	reduce	VERB
artofmedicineimsj-8	56	31	the	the	DET
artofmedicineimsj-8	56	32	tone	tone	NOUN
artofmedicineimsj-8	56	33	of	of	ADP
artofmedicineimsj-8	56	34	the	the	DET
artofmedicineimsj-8	56	35	sympathetic	sympathetic	ADJ
artofmedicineimsj-8	56	36	nervous	nervous	ADJ
artofmedicineimsj-8	56	37	system	system	NOUN
artofmedicineimsj-8	56	38	(	(	PUNCT
artofmedicineimsj-8	56	39	effect	effect	NOUN
artofmedicineimsj-8	56	40	on	on	ADP
artofmedicineimsj-8	56	41	afterload	afterload	NOUN
artofmedicineimsj-8	56	42	)	)	PUNCT
artofmedicineimsj-8	56	43	.	.	PUNCT
artofmedicineimsj-8	57	1	the	the	DET
artofmedicineimsj-8	57	2	main	main	ADJ
artofmedicineimsj-8	57	3	stimulus	stimulus	NOUN
artofmedicineimsj-8	57	4	for	for	ADP
artofmedicineimsj-8	57	5	increased	increase	VERB
artofmedicineimsj-8	57	6	anp	anp	PROPN
artofmedicineimsj-8	57	7	secretion	secretion	NOUN
artofmedicineimsj-8	57	8	is	be	AUX
artofmedicineimsj-8	57	9	atrial	atrial	ADJ
artofmedicineimsj-8	57	10	volume	volume	NOUN
artofmedicineimsj-8	57	11	overload	overload	NOUN
artofmedicineimsj-8	57	12	and	and	CCONJ
artofmedicineimsj-8	57	13	increased	increase	VERB
artofmedicineimsj-8	57	14	myocardial	myocardial	ADJ
artofmedicineimsj-8	57	15	tension	tension	NOUN
artofmedicineimsj-8	57	16	.	.	PUNCT
artofmedicineimsj-8	58	1	among	among	ADP
artofmedicineimsj-8	58	2	the	the	DET
artofmedicineimsj-8	58	3	new	new	ADJ
artofmedicineimsj-8	58	4	drugs	drug	NOUN
artofmedicineimsj-8	58	5	actively	actively	ADV
artofmedicineimsj-8	58	6	developed	develop	VERB
artofmedicineimsj-8	58	7	by	by	ADP
artofmedicineimsj-8	58	8	pharmaceutical	pharmaceutical	ADJ
artofmedicineimsj-8	58	9	companies	company	NOUN
artofmedicineimsj-8	58	10	that	that	PRON
artofmedicineimsj-8	58	11	affect	affect	VERB
artofmedicineimsj-8	58	12	the	the	DET
artofmedicineimsj-8	58	13	kidneys	kidney	NOUN
artofmedicineimsj-8	58	14	by	by	ADP
artofmedicineimsj-8	58	15	normalizing	normalize	VERB
artofmedicineimsj-8	58	16	cardiac	cardiac	ADJ
artofmedicineimsj-8	58	17	activity	activity	NOUN
artofmedicineimsj-8	58	18	is	be	AUX
artofmedicineimsj-8	58	19	the	the	DET
artofmedicineimsj-8	58	20	combined	combined	ADJ
artofmedicineimsj-8	58	21	drug	drug	NOUN
artofmedicineimsj-8	58	22	sacubitril	sacubitril	ADJ
artofmedicineimsj-8	58	23	/	/	SYM
artofmedicineimsj-8	58	24	valsartan	valsartan	PROPN
artofmedicineimsj-8	58	25	(	(	PUNCT
artofmedicineimsj-8	58	26	uperio	uperio	PROPN
artofmedicineimsj-8	58	27	)	)	PUNCT
artofmedicineimsj-8	58	28	.	.	PUNCT
artofmedicineimsj-8	59	1	the	the	DET
artofmedicineimsj-8	59	2	use	use	NOUN
artofmedicineimsj-8	59	3	of	of	ADP
artofmedicineimsj-8	59	4	this	this	DET
artofmedicineimsj-8	59	5	drug	drug	NOUN
artofmedicineimsj-8	59	6	is	be	AUX
artofmedicineimsj-8	59	7	positioned	position	VERB
artofmedicineimsj-8	59	8	with	with	ADP
artofmedicineimsj-8	59	9	an	an	DET
artofmedicineimsj-8	59	10	increase	increase	NOUN
artofmedicineimsj-8	59	11	in	in	ADP
artofmedicineimsj-8	59	12	natriuresis	natriuresis	NOUN
artofmedicineimsj-8	59	13	,	,	PUNCT
artofmedicineimsj-8	59	14	followed	follow	VERB
artofmedicineimsj-8	59	15	by	by	ADP
artofmedicineimsj-8	59	16	a	a	DET
artofmedicineimsj-8	59	17	moderate	moderate	ADJ
artofmedicineimsj-8	59	18	decrease	decrease	NOUN
artofmedicineimsj-8	59	19	in	in	ADP
artofmedicineimsj-8	59	20	blood	blood	NOUN
artofmedicineimsj-8	59	21	pressure	pressure	NOUN
artofmedicineimsj-8	59	22	as	as	ADP
artofmedicineimsj-8	59	23	a	a	DET
artofmedicineimsj-8	59	24	consequence	consequence	NOUN
artofmedicineimsj-8	59	25	of	of	ADP
artofmedicineimsj-8	59	26	the	the	DET
artofmedicineimsj-8	59	27	effect	effect	NOUN
artofmedicineimsj-8	59	28	on	on	ADP
artofmedicineimsj-8	59	29	the	the	DET
artofmedicineimsj-8	59	30	natriuretic	natriuretic	ADJ
artofmedicineimsj-8	59	31	peptide	peptide	NOUN
artofmedicineimsj-8	59	32	and	and	CCONJ
artofmedicineimsj-8	59	33	the	the	DET
artofmedicineimsj-8	59	34	renin	renin	ADJ
artofmedicineimsj-8	59	35	-	-	PUNCT
artofmedicineimsj-8	59	36	angiotensin	angiotensin	NOUN
artofmedicineimsj-8	59	37	aldosterone	aldosterone	NOUN
artofmedicineimsj-8	59	38	system	system	NOUN
artofmedicineimsj-8	59	39	.	.	PUNCT
artofmedicineimsj-8	60	1	normally	normally	ADV
artofmedicineimsj-8	60	2	,	,	PUNCT
artofmedicineimsj-8	60	3	atrial	atrial	ADJ
artofmedicineimsj-8	60	4	natriuretic	natriuretic	ADJ
artofmedicineimsj-8	60	5	peptide	peptide	NOUN
artofmedicineimsj-8	60	6	binds	bind	VERB
artofmedicineimsj-8	60	7	to	to	ADP
artofmedicineimsj-8	60	8	a	a	DET
artofmedicineimsj-8	60	9	specific	specific	ADJ
artofmedicineimsj-8	60	10	set	set	NOUN
artofmedicineimsj-8	60	11	of	of	ADP
artofmedicineimsj-8	60	12	receptors	receptor	NOUN
artofmedicineimsj-8	60	13	:	:	PUNCT
artofmedicineimsj-8	60	14	a	a	DET
artofmedicineimsj-8	60	15	,	,	PUNCT
artofmedicineimsj-8	60	16	b	b	NOUN
artofmedicineimsj-8	60	17	,	,	PUNCT
artofmedicineimsj-8	60	18	and	and	CCONJ
artofmedicineimsj-8	60	19	c	c	X
artofmedicineimsj-8	60	20	(	(	PUNCT
artofmedicineimsj-8	60	21	anp	anp	PROPN
artofmedicineimsj-8	60	22	receptors	receptor	NOUN
artofmedicineimsj-8	60	23	)	)	PUNCT
artofmedicineimsj-8	60	24	.	.	PUNCT
artofmedicineimsj-8	61	1	aand	aand	PROPN
artofmedicineimsj-8	61	2	b	b	NOUN
artofmedicineimsj-8	61	3	-	-	PUNCT
artofmedicineimsj-8	61	4	receptors	receptor	NOUN
artofmedicineimsj-8	61	5	are	be	AUX
artofmedicineimsj-8	61	6	responsible	responsible	ADJ
artofmedicineimsj-8	61	7	for	for	ADP
artofmedicineimsj-8	61	8	the	the	DET
artofmedicineimsj-8	61	9	main	main	ADJ
artofmedicineimsj-8	61	10	actions	action	NOUN
artofmedicineimsj-8	61	11	of	of	ADP
artofmedicineimsj-8	61	12	the	the	DET
artofmedicineimsj-8	61	13	hormone	hormone	NOUN
artofmedicineimsj-8	61	14	,	,	PUNCT
artofmedicineimsj-8	61	15	and	and	CCONJ
artofmedicineimsj-8	61	16	c	c	NOUN
artofmedicineimsj-8	61	17	-	-	PUNCT
artofmedicineimsj-8	61	18	receptors	receptor	NOUN
artofmedicineimsj-8	61	19	are	be	AUX
artofmedicineimsj-8	61	20	located	locate	VERB
artofmedicineimsj-8	61	21	inside	inside	ADP
artofmedicineimsj-8	61	22	cells	cell	NOUN
artofmedicineimsj-8	61	23	,	,	PUNCT
artofmedicineimsj-8	61	24	where	where	SCONJ
artofmedicineimsj-8	61	25	,	,	PUNCT
artofmedicineimsj-8	61	26	by	by	ADP
artofmedicineimsj-8	61	27	binding	bind	VERB
artofmedicineimsj-8	61	28	to	to	ADP
artofmedicineimsj-8	61	29	anp	anp	PROPN
artofmedicineimsj-8	61	30	,	,	PUNCT
artofmedicineimsj-8	61	31	they	they	PRON
artofmedicineimsj-8	61	32	reduce	reduce	VERB
artofmedicineimsj-8	61	33	its	its	PRON
artofmedicineimsj-8	61	34	effect	effect	NOUN
artofmedicineimsj-8	61	35	.	.	PUNCT
artofmedicineimsj-8	62	1	the	the	DET
artofmedicineimsj-8	62	2	attachment	attachment	NOUN
artofmedicineimsj-8	62	3	of	of	ADP
artofmedicineimsj-8	62	4	an	an	DET
artofmedicineimsj-8	62	5	agonist	agonist	NOUN
artofmedicineimsj-8	62	6	to	to	ADP
artofmedicineimsj-8	62	7	these	these	DET
artofmedicineimsj-8	62	8	receptors	receptor	NOUN
artofmedicineimsj-8	62	9	causes	cause	VERB
artofmedicineimsj-8	62	10	a	a	DET
artofmedicineimsj-8	62	11	decrease	decrease	NOUN
artofmedicineimsj-8	62	12	in	in	ADP
artofmedicineimsj-8	62	13	circulating	circulate	VERB
artofmedicineimsj-8	62	14	blood	blood	NOUN
artofmedicineimsj-8	62	15	volume	volume	NOUN
artofmedicineimsj-8	62	16	and	and	CCONJ
artofmedicineimsj-8	62	17	systemic	systemic	ADJ
artofmedicineimsj-8	62	18	arterial	arterial	ADJ
artofmedicineimsj-8	62	19	pressure	pressure	NOUN
artofmedicineimsj-8	62	20	.	.	PUNCT
artofmedicineimsj-8	63	1	in	in	ADP
artofmedicineimsj-8	63	2	this	this	DET
artofmedicineimsj-8	63	3	case	case	NOUN
artofmedicineimsj-8	63	4	,	,	PUNCT
artofmedicineimsj-8	63	5	activation	activation	NOUN
artofmedicineimsj-8	63	6	of	of	ADP
artofmedicineimsj-8	63	7	lipolysis	lipolysis	NOUN
artofmedicineimsj-8	63	8	and	and	CCONJ
artofmedicineimsj-8	63	9	a	a	DET
artofmedicineimsj-8	63	10	decrease	decrease	NOUN
artofmedicineimsj-8	63	11	in	in	ADP
artofmedicineimsj-8	63	12	sodium	sodium	NOUN
artofmedicineimsj-8	63	13	reabsorption	reabsorption	NOUN
artofmedicineimsj-8	63	14	in	in	ADP
artofmedicineimsj-8	63	15	the	the	DET
artofmedicineimsj-8	63	16	renal	renal	ADJ
artofmedicineimsj-8	63	17	tubules	tubule	NOUN
artofmedicineimsj-8	63	18	are	be	AUX
artofmedicineimsj-8	63	19	observed	observe	VERB
artofmedicineimsj-8	63	20	.	.	PUNCT
artofmedicineimsj-8	64	1	the	the	DET
artofmedicineimsj-8	64	2	effect	effect	NOUN
artofmedicineimsj-8	64	3	of	of	ADP
artofmedicineimsj-8	64	4	atrial	atrial	ADJ
artofmedicineimsj-8	64	5	natriuretic	natriuretic	ADJ
artofmedicineimsj-8	64	6	peptide	peptide	NOUN
artofmedicineimsj-8	64	7	is	be	AUX
artofmedicineimsj-8	64	8	opposite	opposite	ADJ
artofmedicineimsj-8	64	9	to	to	ADP
artofmedicineimsj-8	64	10	that	that	PRON
artofmedicineimsj-8	64	11	of	of	ADP
artofmedicineimsj-8	64	12	the	the	DET
artofmedicineimsj-8	64	13	renin	renin	ADJ
artofmedicineimsj-8	64	14	-	-	PUNCT
artofmedicineimsj-8	64	15	angiotensin	angiotensin	NOUN
artofmedicineimsj-8	64	16	system	system	NOUN
artofmedicineimsj-8	64	17	.	.	PUNCT
artofmedicineimsj-8	65	1	according	accord	VERB
artofmedicineimsj-8	65	2	to	to	ADP
artofmedicineimsj-8	65	3	the	the	DET
artofmedicineimsj-8	65	4	literature	literature	NOUN
artofmedicineimsj-8	65	5	,	,	PUNCT
artofmedicineimsj-8	65	6	this	this	DET
artofmedicineimsj-8	65	7	drug	drug	NOUN
artofmedicineimsj-8	65	8	also	also	ADV
artofmedicineimsj-8	65	9	has	have	VERB
artofmedicineimsj-8	65	10	a	a	DET
artofmedicineimsj-8	65	11	nephroprotective	nephroprotective	ADJ
artofmedicineimsj-8	65	12	effect	effect	NOUN
artofmedicineimsj-8	65	13	[	[	X
artofmedicineimsj-8	65	14	4	4	NUM
artofmedicineimsj-8	65	15	]	]	PUNCT
artofmedicineimsj-8	65	16	.	.	PUNCT
artofmedicineimsj-8	66	1	thus	thus	ADV
artofmedicineimsj-8	66	2	,	,	PUNCT
artofmedicineimsj-8	66	3	the	the	DET
artofmedicineimsj-8	66	4	most	most	ADV
artofmedicineimsj-8	66	5	important	important	ADJ
artofmedicineimsj-8	66	6	point	point	NOUN
artofmedicineimsj-8	66	7	that	that	PRON
artofmedicineimsj-8	66	8	determines	determine	VERB
artofmedicineimsj-8	66	9	the	the	DET
artofmedicineimsj-8	66	10	tactics	tactic	NOUN
artofmedicineimsj-8	66	11	of	of	ADP
artofmedicineimsj-8	66	12	managing	manage	VERB
artofmedicineimsj-8	66	13	patients	patient	NOUN
artofmedicineimsj-8	66	14	with	with	ADP
artofmedicineimsj-8	66	15	ckd	ckd	PROPN
artofmedicineimsj-8	66	16	is	be	AUX
artofmedicineimsj-8	66	17	the	the	DET
artofmedicineimsj-8	66	18	recognition	recognition	NOUN
artofmedicineimsj-8	66	19	of	of	ADP
artofmedicineimsj-8	66	20	diabetes	diabetes	NOUN
artofmedicineimsj-8	66	21	as	as	ADP
artofmedicineimsj-8	66	22	an	an	DET
artofmedicineimsj-8	66	23	independent	independent	ADJ
artofmedicineimsj-8	66	24	risk	risk	NOUN
artofmedicineimsj-8	66	25	factor	factor	NOUN
artofmedicineimsj-8	66	26	for	for	ADP
artofmedicineimsj-8	66	27	the	the	DET
artofmedicineimsj-8	66	28	development	development	NOUN
artofmedicineimsj-8	66	29	of	of	ADP
artofmedicineimsj-8	66	30	this	this	DET
artofmedicineimsj-8	66	31	complication	complication	NOUN
artofmedicineimsj-8	66	32	.	.	PUNCT
artofmedicineimsj-8	67	1	patients	patient	NOUN
artofmedicineimsj-8	67	2	with	with	ADP
artofmedicineimsj-8	67	3	diabetes	diabetes	NOUN
artofmedicineimsj-8	67	4	are	be	AUX
artofmedicineimsj-8	67	5	classified	classify	VERB
artofmedicineimsj-8	67	6	as	as	ADP
artofmedicineimsj-8	67	7	high	high	ADJ
artofmedicineimsj-8	67	8	/	/	SYM
artofmedicineimsj-8	67	9	very	very	ADV
artofmedicineimsj-8	67	10	high	high	ADJ
artofmedicineimsj-8	67	11	risk	risk	NOUN
artofmedicineimsj-8	67	12	ckd	ckd	PROPN
artofmedicineimsj-8	67	13	.	.	PUNCT
artofmedicineimsj-8	68	1	accordingly	accordingly	ADV
artofmedicineimsj-8	68	2	,	,	PUNCT
artofmedicineimsj-8	68	3	patients	patient	NOUN
artofmedicineimsj-8	68	4	with	with	ADP
artofmedicineimsj-8	68	5	ckd	ckd	PROPN
artofmedicineimsj-8	68	6	should	should	AUX
artofmedicineimsj-8	68	7	receive	receive	VERB
artofmedicineimsj-8	68	8	full	full	ADJ
artofmedicineimsj-8	68	9	treatment	treatment	NOUN
artofmedicineimsj-8	68	10	in	in	ADP
artofmedicineimsj-8	68	11	accordance	accordance	NOUN
artofmedicineimsj-8	68	12	with	with	ADP
artofmedicineimsj-8	68	13	national	national	ADJ
artofmedicineimsj-8	68	14	and	and	CCONJ
artofmedicineimsj-8	68	15	international	international	ADJ
artofmedicineimsj-8	68	16	guidelines	guideline	NOUN
artofmedicineimsj-8	68	17	,	,	PUNCT
artofmedicineimsj-8	68	18	unless	unless	SCONJ
artofmedicineimsj-8	68	19	contraindicated	contraindicate	VERB
artofmedicineimsj-8	68	20	.	.	PUNCT
artofmedicineimsj-8	69	1	determination	determination	NOUN
artofmedicineimsj-8	69	2	of	of	ADP
artofmedicineimsj-8	69	3	the	the	DET
artofmedicineimsj-8	69	4	role	role	NOUN
artofmedicineimsj-8	69	5	of	of	ADP
artofmedicineimsj-8	69	6	natriuretic	natriuretic	ADJ
artofmedicineimsj-8	69	7	peptides	peptide	NOUN
artofmedicineimsj-8	69	8	in	in	ADP
artofmedicineimsj-8	69	9	preventing	prevent	VERB
artofmedicineimsj-8	69	10	or	or	CCONJ
artofmedicineimsj-8	69	11	slowing	slow	VERB
artofmedicineimsj-8	69	12	down	down	ADP
artofmedicineimsj-8	69	13	the	the	DET
artofmedicineimsj-8	69	14	progress	progress	NOUN
artofmedicineimsj-8	69	15	of	of	ADP
artofmedicineimsj-8	69	16	renal	renal	ADJ
artofmedicineimsj-8	69	17	dysfunction	dysfunction	NOUN
artofmedicineimsj-8	69	18	in	in	ADP
artofmedicineimsj-8	69	19	patients	patient	NOUN
artofmedicineimsj-8	69	20	with	with	ADP
artofmedicineimsj-8	69	21	diabetes	diabetes	NOUN
artofmedicineimsj-8	69	22	mellitus	mellitus	NOUN
artofmedicineimsj-8	69	23	will	will	AUX
artofmedicineimsj-8	69	24	make	make	VERB
artofmedicineimsj-8	69	25	it	it	PRON
artofmedicineimsj-8	69	26	possible	possible	ADJ
artofmedicineimsj-8	69	27	to	to	PART
artofmedicineimsj-8	69	28	scientifically	scientifically	ADV
artofmedicineimsj-8	69	29	substantiate	substantiate	VERB
artofmedicineimsj-8	69	30	their	their	PRON
artofmedicineimsj-8	69	31	use	use	NOUN
artofmedicineimsj-8	69	32	in	in	ADP
artofmedicineimsj-8	69	33	the	the	DET
artofmedicineimsj-8	69	34	treatment	treatment	NOUN
artofmedicineimsj-8	69	35	of	of	ADP
artofmedicineimsj-8	69	36	patients	patient	NOUN
artofmedicineimsj-8	69	37	with	with	ADP
artofmedicineimsj-8	69	38	chronic	chronic	ADJ
artofmedicineimsj-8	69	39	kidney	kidney	NOUN
artofmedicineimsj-8	69	40	disease	disease	NOUN
artofmedicineimsj-8	69	41	of	of	ADP
artofmedicineimsj-8	69	42	diabetic	diabetic	ADJ
artofmedicineimsj-8	69	43	etiology	etiology	NOUN
artofmedicineimsj-8	69	44	.	.	PUNCT
artofmedicineimsj-8	70	1	volume-1	volume-1	PROPN
artofmedicineimsj-8	70	2	issue-1	issue-1	NUM
artofmedicineimsj-8	70	3	art	art	NOUN
artofmedicineimsj-8	70	4	of	of	ADP
artofmedicineimsj-8	70	5	medicine	medicine	NOUN
artofmedicineimsj-8	70	6	international	international	ADJ
artofmedicineimsj-8	70	7	medical	medical	ADJ
artofmedicineimsj-8	70	8	scientific	scientific	ADJ
artofmedicineimsj-8	70	9	journal	journal	NOUN
artofmedicineimsj-8	70	10	7	7	NUM
artofmedicineimsj-8	70	11	the	the	DET
artofmedicineimsj-8	70	12	aim	aim	NOUN
artofmedicineimsj-8	70	13	:	:	PUNCT
artofmedicineimsj-8	70	14	to	to	PART
artofmedicineimsj-8	70	15	study	study	VERB
artofmedicineimsj-8	70	16	,	,	PUNCT
artofmedicineimsj-8	70	17	in	in	ADP
artofmedicineimsj-8	70	18	a	a	DET
artofmedicineimsj-8	70	19	comparative	comparative	ADJ
artofmedicineimsj-8	70	20	aspect	aspect	NOUN
artofmedicineimsj-8	70	21	,	,	PUNCT
artofmedicineimsj-8	70	22	the	the	DET
artofmedicineimsj-8	70	23	functional	functional	ADJ
artofmedicineimsj-8	70	24	state	state	NOUN
artofmedicineimsj-8	70	25	of	of	ADP
artofmedicineimsj-8	70	26	the	the	DET
artofmedicineimsj-8	70	27	kidneys	kidney	NOUN
artofmedicineimsj-8	70	28	in	in	ADP
artofmedicineimsj-8	70	29	patients	patient	NOUN
artofmedicineimsj-8	70	30	with	with	ADP
artofmedicineimsj-8	70	31	chronic	chronic	ADJ
artofmedicineimsj-8	70	32	kidney	kidney	NOUN
artofmedicineimsj-8	70	33	disease	disease	NOUN
artofmedicineimsj-8	70	34	of	of	ADP
artofmedicineimsj-8	70	35	the	the	DET
artofmedicineimsj-8	70	36	ii	ii	PROPN
artofmedicineimsj-8	70	37	-	-	PUNCT
artofmedicineimsj-8	70	38	iii	iii	NUM
artofmedicineimsj-8	70	39	stages	stage	NOUN
artofmedicineimsj-8	70	40	of	of	ADP
artofmedicineimsj-8	70	41	diabetic	diabetic	ADJ
artofmedicineimsj-8	70	42	etiology	etiology	NOUN
artofmedicineimsj-8	70	43	during	during	ADP
artofmedicineimsj-8	70	44	treatment	treatment	NOUN
artofmedicineimsj-8	70	45	with	with	ADP
artofmedicineimsj-8	70	46	the	the	DET
artofmedicineimsj-8	70	47	combined	combine	VERB
artofmedicineimsj-8	70	48	drug	drug	NOUN
artofmedicineimsj-8	70	49	sacubitril	sacubitril	ADJ
artofmedicineimsj-8	70	50	/	/	SYM
artofmedicineimsj-8	70	51	valsartan	valsartan	PROPN
artofmedicineimsj-8	70	52	.	.	PUNCT
artofmedicineimsj-8	71	1	material	material	NOUN
artofmedicineimsj-8	71	2	and	and	CCONJ
artofmedicineimsj-8	71	3	methods	method	NOUN
artofmedicineimsj-8	71	4	:	:	PUNCT
artofmedicineimsj-8	71	5	the	the	DET
artofmedicineimsj-8	71	6	study	study	NOUN
artofmedicineimsj-8	71	7	included	include	VERB
artofmedicineimsj-8	71	8	68	68	NUM
artofmedicineimsj-8	71	9	patients	patient	NOUN
artofmedicineimsj-8	71	10	(	(	PUNCT
artofmedicineimsj-8	71	11	36	36	NUM
artofmedicineimsj-8	71	12	men	man	NOUN
artofmedicineimsj-8	71	13	and	and	CCONJ
artofmedicineimsj-8	71	14	32	32	NUM
artofmedicineimsj-8	71	15	women	woman	NOUN
artofmedicineimsj-8	71	16	)	)	PUNCT
artofmedicineimsj-8	71	17	who	who	PRON
artofmedicineimsj-8	71	18	were	be	AUX
artofmedicineimsj-8	71	19	hospitalized	hospitalize	VERB
artofmedicineimsj-8	71	20	at	at	ADP
artofmedicineimsj-8	71	21	the	the	DET
artofmedicineimsj-8	71	22	republican	republican	PROPN
artofmedicineimsj-8	71	23	scientific	scientific	ADJ
artofmedicineimsj-8	71	24	and	and	CCONJ
artofmedicineimsj-8	71	25	practical	practical	ADJ
artofmedicineimsj-8	71	26	center	center	NOUN
artofmedicineimsj-8	71	27	of	of	ADP
artofmedicineimsj-8	71	28	nephrology	nephrology	NOUN
artofmedicineimsj-8	71	29	on	on	ADP
artofmedicineimsj-8	71	30	the	the	DET
artofmedicineimsj-8	71	31	basis	basis	NOUN
artofmedicineimsj-8	71	32	of	of	ADP
artofmedicineimsj-8	71	33	the	the	DET
artofmedicineimsj-8	71	34	iii	iii	PROPN
artofmedicineimsj-8	71	35	clinic	clinic	NOUN
artofmedicineimsj-8	71	36	of	of	ADP
artofmedicineimsj-8	71	37	tma	tma	PROPN
artofmedicineimsj-8	71	38	,	,	PUNCT
artofmedicineimsj-8	71	39	with	with	ADP
artofmedicineimsj-8	71	40	a	a	DET
artofmedicineimsj-8	71	41	clinically	clinically	ADV
artofmedicineimsj-8	71	42	established	establish	VERB
artofmedicineimsj-8	71	43	diagnosis	diagnosis	NOUN
artofmedicineimsj-8	71	44	of	of	ADP
artofmedicineimsj-8	71	45	type	type	NOUN
artofmedicineimsj-8	71	46	2	2	NUM
artofmedicineimsj-8	71	47	diabetes	diabetes	NOUN
artofmedicineimsj-8	71	48	with	with	ADP
artofmedicineimsj-8	71	49	diabetic	diabetic	ADJ
artofmedicineimsj-8	71	50	nephropathy	nephropathy	NOUN
artofmedicineimsj-8	71	51	.	.	PUNCT
artofmedicineimsj-8	72	1	the	the	DET
artofmedicineimsj-8	72	2	average	average	ADJ
artofmedicineimsj-8	72	3	age	age	NOUN
artofmedicineimsj-8	72	4	of	of	ADP
artofmedicineimsj-8	72	5	the	the	DET
artofmedicineimsj-8	72	6	patients	patient	NOUN
artofmedicineimsj-8	72	7	was	be	AUX
artofmedicineimsj-8	72	8	56.0	56.0	NUM
artofmedicineimsj-8	72	9	±	±	NUM
artofmedicineimsj-8	72	10	0.4	0.4	NUM
artofmedicineimsj-8	72	11	years	year	NOUN
artofmedicineimsj-8	72	12	,	,	PUNCT
artofmedicineimsj-8	72	13	the	the	DET
artofmedicineimsj-8	72	14	duration	duration	NOUN
artofmedicineimsj-8	72	15	of	of	ADP
artofmedicineimsj-8	72	16	type	type	NOUN
artofmedicineimsj-8	72	17	2	2	NUM
artofmedicineimsj-8	72	18	diabetes	diabetes	NOUN
artofmedicineimsj-8	72	19	was	be	AUX
artofmedicineimsj-8	72	20	11.8	11.8	NUM
artofmedicineimsj-8	72	21	±	±	NUM
artofmedicineimsj-8	72	22	0.3	0.3	NUM
artofmedicineimsj-8	72	23	years	year	NOUN
artofmedicineimsj-8	72	24	.	.	PUNCT
artofmedicineimsj-8	73	1	these	these	DET
artofmedicineimsj-8	73	2	patients	patient	NOUN
artofmedicineimsj-8	73	3	received	receive	VERB
artofmedicineimsj-8	73	4	traditional	traditional	ADJ
artofmedicineimsj-8	73	5	basic	basic	ADJ
artofmedicineimsj-8	73	6	therapy	therapy	NOUN
artofmedicineimsj-8	73	7	.	.	PUNCT
artofmedicineimsj-8	74	1	patients	patient	NOUN
artofmedicineimsj-8	74	2	(	(	PUNCT
artofmedicineimsj-8	74	3	n	n	NOUN
artofmedicineimsj-8	74	4	=	=	SYM
artofmedicineimsj-8	74	5	68	68	NUM
artofmedicineimsj-8	74	6	)	)	PUNCT
artofmedicineimsj-8	74	7	were	be	AUX
artofmedicineimsj-8	74	8	divided	divide	VERB
artofmedicineimsj-8	74	9	into	into	ADP
artofmedicineimsj-8	74	10	two	two	NUM
artofmedicineimsj-8	74	11	groups	group	NOUN
artofmedicineimsj-8	74	12	that	that	PRON
artofmedicineimsj-8	74	13	did	do	AUX
artofmedicineimsj-8	74	14	not	not	PART
artofmedicineimsj-8	74	15	differ	differ	VERB
artofmedicineimsj-8	74	16	in	in	ADP
artofmedicineimsj-8	74	17	age	age	NOUN
artofmedicineimsj-8	74	18	,	,	PUNCT
artofmedicineimsj-8	74	19	sex	sex	NOUN
artofmedicineimsj-8	74	20	and	and	CCONJ
artofmedicineimsj-8	74	21	duration	duration	NOUN
artofmedicineimsj-8	74	22	of	of	ADP
artofmedicineimsj-8	74	23	the	the	DET
artofmedicineimsj-8	74	24	disease	disease	NOUN
artofmedicineimsj-8	74	25	,	,	PUNCT
artofmedicineimsj-8	74	26	and	and	CCONJ
artofmedicineimsj-8	74	27	clinical	clinical	ADJ
artofmedicineimsj-8	74	28	and	and	CCONJ
artofmedicineimsj-8	74	29	laboratory	laboratory	NOUN
artofmedicineimsj-8	74	30	parameters	parameter	NOUN
artofmedicineimsj-8	74	31	.	.	PUNCT
artofmedicineimsj-8	75	1	the	the	DET
artofmedicineimsj-8	75	2	studied	study	VERB
artofmedicineimsj-8	75	3	patients	patient	NOUN
artofmedicineimsj-8	75	4	of	of	ADP
artofmedicineimsj-8	75	5	the	the	DET
artofmedicineimsj-8	75	6	1st	1st	NOUN
artofmedicineimsj-8	75	7	(	(	PUNCT
artofmedicineimsj-8	75	8	n	n	NOUN
artofmedicineimsj-8	75	9	=	=	NUM
artofmedicineimsj-8	75	10	35	35	NUM
artofmedicineimsj-8	75	11	)	)	PUNCT
artofmedicineimsj-8	75	12	and	and	CCONJ
artofmedicineimsj-8	75	13	the	the	DET
artofmedicineimsj-8	75	14	2nd	2nd	ADJ
artofmedicineimsj-8	75	15	group	group	NOUN
artofmedicineimsj-8	75	16	(	(	PUNCT
artofmedicineimsj-8	75	17	n	n	NOUN
artofmedicineimsj-8	75	18	=	=	SYM
artofmedicineimsj-8	75	19	33	33	NUM
artofmedicineimsj-8	75	20	)	)	PUNCT
artofmedicineimsj-8	75	21	underwent	underwent	ADJ
artofmedicineimsj-8	75	22	general	general	ADJ
artofmedicineimsj-8	75	23	clinical	clinical	ADJ
artofmedicineimsj-8	75	24	and	and	CCONJ
artofmedicineimsj-8	75	25	biochemical	biochemical	ADJ
artofmedicineimsj-8	75	26	analyzes	analyze	NOUN
artofmedicineimsj-8	75	27	,	,	PUNCT
artofmedicineimsj-8	75	28	echocardiography	echocardiography	NOUN
artofmedicineimsj-8	75	29	in	in	ADP
artofmedicineimsj-8	75	30	b	b	NOUN
artofmedicineimsj-8	75	31	-	-	PUNCT
artofmedicineimsj-8	75	32	modes	mode	NOUN
artofmedicineimsj-8	75	33	.	.	PUNCT
artofmedicineimsj-8	76	1	echocardiographic	echocardiographic	ADJ
artofmedicineimsj-8	76	2	examination	examination	NOUN
artofmedicineimsj-8	76	3	was	be	AUX
artofmedicineimsj-8	76	4	performed	perform	VERB
artofmedicineimsj-8	76	5	on	on	ADP
artofmedicineimsj-8	76	6	a	a	DET
artofmedicineimsj-8	76	7	sonoscape	sonoscape	NOUN
artofmedicineimsj-8	76	8	s20	s20	NOUN
artofmedicineimsj-8	76	9	ultrasound	ultrasound	NOUN
artofmedicineimsj-8	76	10	machine	machine	NOUN
artofmedicineimsj-8	76	11	using	use	VERB
artofmedicineimsj-8	76	12	a	a	DET
artofmedicineimsj-8	76	13	3.5	3.5	NUM
artofmedicineimsj-8	76	14	mhz	mhz	NOUN
artofmedicineimsj-8	76	15	cardiac	cardiac	ADJ
artofmedicineimsj-8	76	16	transducer	transducer	NOUN
artofmedicineimsj-8	76	17	in	in	ADP
artofmedicineimsj-8	76	18	modes	mode	NOUN
artofmedicineimsj-8	76	19	according	accord	VERB
artofmedicineimsj-8	76	20	to	to	ADP
artofmedicineimsj-8	76	21	the	the	DET
artofmedicineimsj-8	76	22	standard	standard	ADJ
artofmedicineimsj-8	76	23	simson	simson	PROPN
artofmedicineimsj-8	76	24	technique	technique	NOUN
artofmedicineimsj-8	76	25	.	.	PUNCT
artofmedicineimsj-8	77	1	glomerular	glomerular	ADJ
artofmedicineimsj-8	77	2	filtration	filtration	NOUN
artofmedicineimsj-8	77	3	rate	rate	NOUN
artofmedicineimsj-8	77	4	(	(	PUNCT
artofmedicineimsj-8	77	5	gfr	gfr	NOUN
artofmedicineimsj-8	77	6	)	)	PUNCT
artofmedicineimsj-8	77	7	was	be	AUX
artofmedicineimsj-8	77	8	determined	determine	VERB
artofmedicineimsj-8	77	9	using	use	VERB
artofmedicineimsj-8	77	10	the	the	DET
artofmedicineimsj-8	77	11	ckd	ckd	NOUN
artofmedicineimsj-8	77	12	-	-	PUNCT
artofmedicineimsj-8	77	13	epi	epi	NOUN
artofmedicineimsj-8	77	14	formula	formula	NOUN
artofmedicineimsj-8	77	15	(	(	PUNCT
artofmedicineimsj-8	77	16	ml	ml	INTJ
artofmedicineimsj-8	77	17	/	/	SYM
artofmedicineimsj-8	77	18	min	min	PROPN
artofmedicineimsj-8	77	19	/	/	SYM
artofmedicineimsj-8	77	20	1.73	1.73	NUM
artofmedicineimsj-8	77	21	m2	m2	NOUN
artofmedicineimsj-8	77	22	)	)	PUNCT
artofmedicineimsj-8	77	23	.	.	PUNCT
artofmedicineimsj-8	78	1	results	result	NOUN
artofmedicineimsj-8	78	2	and	and	CCONJ
artofmedicineimsj-8	78	3	discussion	discussion	NOUN
artofmedicineimsj-8	78	4	:	:	PUNCT
artofmedicineimsj-8	78	5	to	to	PART
artofmedicineimsj-8	78	6	compensate	compensate	VERB
artofmedicineimsj-8	78	7	for	for	ADP
artofmedicineimsj-8	78	8	renocardiac	renocardiac	ADJ
artofmedicineimsj-8	78	9	syndrome	syndrome	NOUN
artofmedicineimsj-8	78	10	,	,	PUNCT
artofmedicineimsj-8	78	11	patients	patient	NOUN
artofmedicineimsj-8	78	12	of	of	ADP
artofmedicineimsj-8	78	13	group	group	NOUN
artofmedicineimsj-8	78	14	i	i	PRON
artofmedicineimsj-8	78	15	received	receive	VERB
artofmedicineimsj-8	78	16	a	a	DET
artofmedicineimsj-8	78	17	combined	combine	VERB
artofmedicineimsj-8	78	18	drug	drug	NOUN
artofmedicineimsj-8	78	19	sacubitril	sacubitril	NOUN
artofmedicineimsj-8	78	20	/	/	PUNCT
artofmedicineimsj-8	78	21	valsartan	valsartan	VERB
artofmedicineimsj-8	78	22	in	in	ADP
artofmedicineimsj-8	78	23	a	a	DET
artofmedicineimsj-8	78	24	daily	daily	ADJ
artofmedicineimsj-8	78	25	dose	dose	NOUN
artofmedicineimsj-8	78	26	of	of	ADP
artofmedicineimsj-8	78	27	200	200	NUM
artofmedicineimsj-8	78	28	mg	mg	NOUN
artofmedicineimsj-8	78	29	.	.	PUNCT
artofmedicineimsj-8	79	1	patients	patient	NOUN
artofmedicineimsj-8	79	2	of	of	ADP
artofmedicineimsj-8	79	3	the	the	DET
artofmedicineimsj-8	79	4	second	second	ADJ
artofmedicineimsj-8	79	5	group	group	NOUN
artofmedicineimsj-8	79	6	were	be	AUX
artofmedicineimsj-8	79	7	prescribed	prescribe	VERB
artofmedicineimsj-8	79	8	an	an	DET
artofmedicineimsj-8	79	9	angiotensin	angiotensin	NOUN
artofmedicineimsj-8	79	10	receptor	receptor	NOUN
artofmedicineimsj-8	79	11	antagonist	antagonist	NOUN
artofmedicineimsj-8	79	12	valsartan	valsartan	VERB
artofmedicineimsj-8	79	13	in	in	ADP
artofmedicineimsj-8	79	14	a	a	DET
artofmedicineimsj-8	79	15	daily	daily	ADJ
artofmedicineimsj-8	79	16	dose	dose	NOUN
artofmedicineimsj-8	79	17	of	of	ADP
artofmedicineimsj-8	79	18	160	160	NUM
artofmedicineimsj-8	79	19	mg	mg	NOUN
artofmedicineimsj-8	79	20	.	.	PUNCT
artofmedicineimsj-8	80	1	the	the	DET
artofmedicineimsj-8	80	2	control	control	NOUN
artofmedicineimsj-8	80	3	points	point	NOUN
artofmedicineimsj-8	80	4	of	of	ADP
artofmedicineimsj-8	80	5	the	the	DET
artofmedicineimsj-8	80	6	study	study	NOUN
artofmedicineimsj-8	80	7	were	be	AUX
artofmedicineimsj-8	80	8	the	the	DET
artofmedicineimsj-8	80	9	first	first	ADJ
artofmedicineimsj-8	80	10	and	and	CCONJ
artofmedicineimsj-8	80	11	thirtieth	thirtieth	ADJ
artofmedicineimsj-8	80	12	day	day	NOUN
artofmedicineimsj-8	80	13	of	of	ADP
artofmedicineimsj-8	80	14	treatment	treatment	NOUN
artofmedicineimsj-8	80	15	.	.	PUNCT
artofmedicineimsj-8	81	1	the	the	DET
artofmedicineimsj-8	81	2	results	result	NOUN
artofmedicineimsj-8	81	3	of	of	ADP
artofmedicineimsj-8	81	4	therapy	therapy	NOUN
artofmedicineimsj-8	81	5	were	be	AUX
artofmedicineimsj-8	81	6	evaluated	evaluate	VERB
artofmedicineimsj-8	81	7	by	by	ADP
artofmedicineimsj-8	81	8	comparison	comparison	NOUN
artofmedicineimsj-8	81	9	(	(	PUNCT
artofmedicineimsj-8	81	10	table	table	NOUN
artofmedicineimsj-8	81	11	1	1	NUM
artofmedicineimsj-8	81	12	)	)	PUNCT
artofmedicineimsj-8	81	13	.	.	PUNCT
artofmedicineimsj-8	82	1	table	table	NOUN
artofmedicineimsj-8	82	2	1	1	NUM
artofmedicineimsj-8	82	3	.	.	PUNCT
artofmedicineimsj-8	83	1	dynamics	dynamic	NOUN
artofmedicineimsj-8	83	2	of	of	ADP
artofmedicineimsj-8	83	3	blood	blood	NOUN
artofmedicineimsj-8	83	4	biochemical	biochemical	ADJ
artofmedicineimsj-8	83	5	parameters	parameter	NOUN
artofmedicineimsj-8	83	6	in	in	ADP
artofmedicineimsj-8	83	7	patients	patient	NOUN
artofmedicineimsj-8	83	8	with	with	ADP
artofmedicineimsj-8	83	9	chronic	chronic	ADJ
artofmedicineimsj-8	83	10	kidney	kidney	NOUN
artofmedicineimsj-8	83	11	disease	disease	NOUN
artofmedicineimsj-8	83	12	on	on	ADP
artofmedicineimsj-8	83	13	the	the	DET
artofmedicineimsj-8	83	14	background	background	NOUN
artofmedicineimsj-8	83	15	of	of	ADP
artofmedicineimsj-8	83	16	type	type	NOUN
artofmedicineimsj-8	83	17	2	2	NUM
artofmedicineimsj-8	83	18	diabetes	diabetes	NOUN
artofmedicineimsj-8	83	19	№	№	NUM
artofmedicineimsj-8	83	20	indicators	indicator	NOUN
artofmedicineimsj-8	83	21	group	group	NOUN
artofmedicineimsj-8	83	22	i	i	PRON
artofmedicineimsj-8	83	23	group	group	NOUN
artofmedicineimsj-8	83	24	ii	ii	PROPN
artofmedicineimsj-8	83	25	1st	1st	ADJ
artofmedicineimsj-8	83	26	day	day	NOUN
artofmedicineimsj-8	83	27	30th	30th	ADJ
artofmedicineimsj-8	83	28	day	day	NOUN
artofmedicineimsj-8	83	29	1st	1st	ADJ
artofmedicineimsj-8	83	30	day	day	NOUN
artofmedicineimsj-8	83	31	30th	30th	ADJ
artofmedicineimsj-8	83	32	day	day	NOUN
artofmedicineimsj-8	83	33	1	1	NUM
artofmedicineimsj-8	83	34	urea	urea	NOUN
artofmedicineimsj-8	83	35	,	,	PUNCT
artofmedicineimsj-8	83	36	mmol	mmol	NOUN
artofmedicineimsj-8	83	37	/	/	SYM
artofmedicineimsj-8	83	38	l	l	NOUN
artofmedicineimsj-8	83	39	12,4±0,51	12,4±0,51	NUM
artofmedicineimsj-8	83	40	9,03±0,71	9,03±0,71	NOUN
artofmedicineimsj-8	83	41	*	*	PROPN
artofmedicineimsj-8	83	42	*	*	X
artofmedicineimsj-8	83	43	11,6±0,83	11,6±0,83	NUM
artofmedicineimsj-8	83	44	9,6±1,56	9,6±1,56	NUM
artofmedicineimsj-8	83	45	*	*	SYM
artofmedicineimsj-8	83	46	2	2	NUM
artofmedicineimsj-8	83	47	creatinine	creatinine	NOUN
artofmedicineimsj-8	83	48	,	,	PUNCT
artofmedicineimsj-8	83	49	mmol	mmol	NOUN
artofmedicineimsj-8	83	50	/	/	SYM
artofmedicineimsj-8	83	51	l	l	NOUN
artofmedicineimsj-8	83	52	163,4±12,3	163,4±12,3	NUM
artofmedicineimsj-8	83	53	1	1	NUM
artofmedicineimsj-8	83	54	142,6±8,5	142,6±8,5	NUM
artofmedicineimsj-8	83	55	*	*	PUNCT
artofmedicineimsj-8	83	56	*	*	PUNCT
artofmedicineimsj-8	83	57	159,6±7,81	159,6±7,81	NUM
artofmedicineimsj-8	83	58	150,8±6,04	150,8±6,04	NUM
artofmedicineimsj-8	83	59	*	*	SYM
artofmedicineimsj-8	83	60	3	3	NUM
artofmedicineimsj-8	83	61	total	total	ADJ
artofmedicineimsj-8	83	62	cholesterol	cholesterol	NOUN
artofmedicineimsj-8	83	63	,	,	PUNCT
artofmedicineimsj-8	83	64	mmol	mmol	NOUN
artofmedicineimsj-8	83	65	/	/	SYM
artofmedicineimsj-8	83	66	l	l	NOUN
artofmedicineimsj-8	83	67	6,38±0,43	6,38±0,43	NUM
artofmedicineimsj-8	83	68	5,71±0,13	5,71±0,13	NUM
artofmedicineimsj-8	83	69	*	*	PUNCT
artofmedicineimsj-8	83	70	6,29±0,39	6,29±0,39	NOUN
artofmedicineimsj-8	84	1	5,91±0,18	5,91±0,18	NOUN
artofmedicineimsj-8	84	2	*	*	SYM
artofmedicineimsj-8	84	3	4	4	NUM
artofmedicineimsj-8	84	4	tg	tg	PROPN
artofmedicineimsj-8	84	5	mmol	mmol	NOUN
artofmedicineimsj-8	84	6	/	/	SYM
artofmedicineimsj-8	84	7	l	l	NOUN
artofmedicineimsj-8	84	8	2,32±0,45	2,32±0,45	NUM
artofmedicineimsj-8	84	9	1,65±0,23	1,65±0,23	NUM
artofmedicineimsj-8	84	10	*	*	PUNCT
artofmedicineimsj-8	84	11	*	*	PUNCT
artofmedicineimsj-8	85	1	2,29±0,31	2,29±0,31	NUM
artofmedicineimsj-8	85	2	1,78±0,27	1,78±0,27	NUM
artofmedicineimsj-8	85	3	*	*	SYM
artofmedicineimsj-8	85	4	5	5	NUM
artofmedicineimsj-8	85	5	ldl	ldl	NOUN
artofmedicineimsj-8	85	6	mmol	mmol	NOUN
artofmedicineimsj-8	85	7	/	/	SYM
artofmedicineimsj-8	85	8	l	l	NOUN
artofmedicineimsj-8	85	9	4,1±1,12	4,1±1,12	NUM
artofmedicineimsj-8	85	10	3,18±0,32	3,18±0,32	NUM
artofmedicineimsj-8	85	11	*	*	PUNCT
artofmedicineimsj-8	85	12	*	*	PUNCT
artofmedicineimsj-8	85	13	4,22±1,24	4,22±1,24	PROPN
artofmedicineimsj-8	86	1	3,32±0,31	3,32±0,31	NUM
artofmedicineimsj-8	86	2	*	*	SYM
artofmedicineimsj-8	86	3	6	6	NUM
artofmedicineimsj-8	86	4	hdl	hdl	PROPN
artofmedicineimsj-8	86	5	mmol	mmol	PROPN
artofmedicineimsj-8	86	6	/	/	SYM
artofmedicineimsj-8	86	7	l	l	NOUN
artofmedicineimsj-8	86	8	1,09±0,25	1,09±0,25	NUM
artofmedicineimsj-8	87	1	1,22±0,32	1,22±0,32	NUM
artofmedicineimsj-8	87	2	1,07±0,31	1,07±0,31	NUM
artofmedicineimsj-8	87	3	1,18±0,26	1,18±0,26	ADJ
artofmedicineimsj-8	87	4	note	note	NOUN
artofmedicineimsj-8	87	5	:	:	PUNCT
artofmedicineimsj-8	87	6	delivery	delivery	NOUN
artofmedicineimsj-8	87	7	*	*	PUNCT
artofmedicineimsj-8	88	1	р<0.05	р<0.05	PROPN
artofmedicineimsj-8	88	2	.	.	PUNCT
artofmedicineimsj-8	89	1	*	*	PUNCT
artofmedicineimsj-8	89	2	*	*	PUNCT
artofmedicineimsj-8	89	3	р<0.01	р<0.01	PROPN
artofmedicineimsj-8	89	4	.	.	PUNCT
artofmedicineimsj-8	90	1	according	accord	VERB
artofmedicineimsj-8	90	2	to	to	ADP
artofmedicineimsj-8	90	3	the	the	DET
artofmedicineimsj-8	90	4	data	datum	NOUN
artofmedicineimsj-8	90	5	given	give	VERB
artofmedicineimsj-8	90	6	in	in	ADP
artofmedicineimsj-8	90	7	the	the	DET
artofmedicineimsj-8	90	8	first	first	ADJ
artofmedicineimsj-8	90	9	table	table	NOUN
artofmedicineimsj-8	90	10	,	,	PUNCT
artofmedicineimsj-8	90	11	we	we	PRON
artofmedicineimsj-8	90	12	can	can	AUX
artofmedicineimsj-8	90	13	say	say	VERB
artofmedicineimsj-8	90	14	that	that	SCONJ
artofmedicineimsj-8	90	15	,	,	PUNCT
artofmedicineimsj-8	90	16	in	in	ADP
artofmedicineimsj-8	90	17	both	both	DET
artofmedicineimsj-8	90	18	groups	group	NOUN
artofmedicineimsj-8	90	19	,	,	PUNCT
artofmedicineimsj-8	90	20	the	the	DET
artofmedicineimsj-8	90	21	biochemical	biochemical	ADJ
artofmedicineimsj-8	90	22	parameters	parameter	NOUN
artofmedicineimsj-8	90	23	of	of	ADP
artofmedicineimsj-8	90	24	blood	blood	NOUN
artofmedicineimsj-8	90	25	have	have	AUX
artofmedicineimsj-8	90	26	changed	change	VERB
artofmedicineimsj-8	90	27	with	with	ADP
artofmedicineimsj-8	90	28	positive	positive	ADJ
artofmedicineimsj-8	90	29	dynamics	dynamic	NOUN
artofmedicineimsj-8	90	30	.	.	PUNCT
artofmedicineimsj-8	91	1	in	in	ADP
artofmedicineimsj-8	91	2	particular	particular	ADJ
artofmedicineimsj-8	91	3	,	,	PUNCT
artofmedicineimsj-8	91	4	in	in	ADP
artofmedicineimsj-8	91	5	patients	patient	NOUN
artofmedicineimsj-8	91	6	of	of	ADP
artofmedicineimsj-8	91	7	the	the	DET
artofmedicineimsj-8	91	8	first	first	ADJ
artofmedicineimsj-8	91	9	group	group	NOUN
artofmedicineimsj-8	91	10	,	,	PUNCT
artofmedicineimsj-8	91	11	urea	urea	PROPN
artofmedicineimsj-8	91	12	decreased	decrease	VERB
artofmedicineimsj-8	91	13	by	by	ADP
artofmedicineimsj-8	91	14	24.2	24.2	NUM
artofmedicineimsj-8	91	15	%	%	NOUN
artofmedicineimsj-8	91	16	,	,	PUNCT
artofmedicineimsj-8	91	17	and	and	CCONJ
artofmedicineimsj-8	91	18	in	in	ADP
artofmedicineimsj-8	91	19	the	the	DET
artofmedicineimsj-8	91	20	second	second	ADJ
artofmedicineimsj-8	91	21	group	group	NOUN
artofmedicineimsj-8	91	22	by	by	ADP
artofmedicineimsj-8	91	23	17.25	17.25	NUM
artofmedicineimsj-8	91	24	%	%	NOUN
artofmedicineimsj-8	91	25	compared	compare	VERB
artofmedicineimsj-8	91	26	with	with	ADP
artofmedicineimsj-8	91	27	the	the	DET
artofmedicineimsj-8	91	28	initial	initial	ADJ
artofmedicineimsj-8	91	29	indicator	indicator	NOUN
artofmedicineimsj-8	91	30	,	,	PUNCT
artofmedicineimsj-8	91	31	respectively	respectively	ADV
artofmedicineimsj-8	91	32	.	.	PUNCT
artofmedicineimsj-8	92	1	if	if	SCONJ
artofmedicineimsj-8	92	2	in	in	ADP
artofmedicineimsj-8	92	3	the	the	DET
artofmedicineimsj-8	92	4	first	first	ADJ
artofmedicineimsj-8	92	5	group	group	NOUN
artofmedicineimsj-8	92	6	the	the	DET
artofmedicineimsj-8	92	7	concentration	concentration	NOUN
artofmedicineimsj-8	92	8	of	of	ADP
artofmedicineimsj-8	92	9	creatinine	creatinine	NOUN
artofmedicineimsj-8	92	10	in	in	ADP
artofmedicineimsj-8	92	11	the	the	DET
artofmedicineimsj-8	92	12	blood	blood	NOUN
artofmedicineimsj-8	92	13	decreased	decrease	VERB
artofmedicineimsj-8	92	14	by	by	ADP
artofmedicineimsj-8	92	15	12.7	12.7	NUM
artofmedicineimsj-8	92	16	%	%	NOUN
artofmedicineimsj-8	92	17	,	,	PUNCT
artofmedicineimsj-8	92	18	then	then	ADV
artofmedicineimsj-8	92	19	in	in	ADP
artofmedicineimsj-8	92	20	the	the	DET
artofmedicineimsj-8	92	21	second	second	ADJ
artofmedicineimsj-8	92	22	group	group	NOUN
artofmedicineimsj-8	92	23	this	this	DET
artofmedicineimsj-8	92	24	indicator	indicator	NOUN
artofmedicineimsj-8	92	25	changed	change	VERB
artofmedicineimsj-8	92	26	by	by	ADP
artofmedicineimsj-8	92	27	5.51	5.51	NUM
artofmedicineimsj-8	92	28	%	%	NOUN
artofmedicineimsj-8	92	29	with	with	ADP
artofmedicineimsj-8	92	30	positive	positive	ADJ
artofmedicineimsj-8	92	31	dynamics	dynamic	NOUN
artofmedicineimsj-8	92	32	.	.	PUNCT
artofmedicineimsj-8	93	1	thus	thus	ADV
artofmedicineimsj-8	93	2	,	,	PUNCT
artofmedicineimsj-8	93	3	on	on	ADP
artofmedicineimsj-8	93	4	the	the	DET
artofmedicineimsj-8	93	5	background	background	NOUN
artofmedicineimsj-8	93	6	of	of	ADP
artofmedicineimsj-8	93	7	treatment	treatment	NOUN
artofmedicineimsj-8	93	8	in	in	ADP
artofmedicineimsj-8	93	9	both	both	DET
artofmedicineimsj-8	93	10	groups	group	NOUN
artofmedicineimsj-8	93	11	,	,	PUNCT
artofmedicineimsj-8	93	12	the	the	DET
artofmedicineimsj-8	93	13	blood	blood	NOUN
artofmedicineimsj-8	93	14	urea	urea	NOUN
artofmedicineimsj-8	93	15	and	and	CCONJ
artofmedicineimsj-8	93	16	creatine	creatine	NOUN
artofmedicineimsj-8	93	17	levels	level	NOUN
artofmedicineimsj-8	93	18	significantly	significantly	ADV
artofmedicineimsj-8	93	19	improved	improve	VERB
artofmedicineimsj-8	93	20	,	,	PUNCT
artofmedicineimsj-8	93	21	but	but	CCONJ
artofmedicineimsj-8	93	22	more	more	ADV
artofmedicineimsj-8	93	23	significantly	significantly	ADV
artofmedicineimsj-8	93	24	in	in	ADP
artofmedicineimsj-8	93	25	the	the	DET
artofmedicineimsj-8	93	26	first	first	ADJ
artofmedicineimsj-8	93	27	group	group	NOUN
artofmedicineimsj-8	93	28	(	(	PUNCT
artofmedicineimsj-8	93	29	p	p	X
artofmedicineimsj-8	93	30	<	<	X
artofmedicineimsj-8	93	31	0.01	0.01	NUM
artofmedicineimsj-8	93	32	)	)	PUNCT
artofmedicineimsj-8	93	33	than	than	ADP
artofmedicineimsj-8	93	34	in	in	ADP
artofmedicineimsj-8	93	35	the	the	DET
artofmedicineimsj-8	93	36	second	second	ADJ
artofmedicineimsj-8	93	37	group	group	NOUN
artofmedicineimsj-8	93	38	(	(	PUNCT
artofmedicineimsj-8	93	39	p	p	X
artofmedicineimsj-8	93	40	<	<	X
artofmedicineimsj-8	93	41	0.05	0.05	NUM
artofmedicineimsj-8	93	42	)	)	PUNCT
artofmedicineimsj-8	93	43	.	.	PUNCT
artofmedicineimsj-8	94	1	when	when	SCONJ
artofmedicineimsj-8	94	2	determining	determine	VERB
artofmedicineimsj-8	94	3	the	the	DET
artofmedicineimsj-8	94	4	lipid	lipid	NOUN
artofmedicineimsj-8	94	5	profile	profile	NOUN
artofmedicineimsj-8	94	6	in	in	ADP
artofmedicineimsj-8	94	7	the	the	DET
artofmedicineimsj-8	94	8	studied	studied	ADJ
artofmedicineimsj-8	94	9	patients	patient	NOUN
artofmedicineimsj-8	94	10	,	,	PUNCT
artofmedicineimsj-8	94	11	an	an	DET
artofmedicineimsj-8	94	12	increased	increase	VERB
artofmedicineimsj-8	94	13	level	level	NOUN
artofmedicineimsj-8	94	14	of	of	ADP
artofmedicineimsj-8	94	15	tg	tg	PROPN
artofmedicineimsj-8	94	16	,	,	PUNCT
artofmedicineimsj-8	94	17	cholesterol	cholesterol	NOUN
artofmedicineimsj-8	94	18	and	and	CCONJ
artofmedicineimsj-8	94	19	ldl	ldl	NOUN
artofmedicineimsj-8	94	20	was	be	AUX
artofmedicineimsj-8	94	21	observed	observe	VERB
artofmedicineimsj-8	94	22	in	in	ADP
artofmedicineimsj-8	94	23	44	44	NUM
artofmedicineimsj-8	94	24	(	(	PUNCT
artofmedicineimsj-8	94	25	63.63	63.63	NUM
artofmedicineimsj-8	94	26	%	%	NOUN
artofmedicineimsj-8	94	27	)	)	PUNCT
artofmedicineimsj-8	94	28	,	,	PUNCT
artofmedicineimsj-8	94	29	68	68	NUM
artofmedicineimsj-8	94	30	(	(	PUNCT
artofmedicineimsj-8	94	31	100	100	NUM
artofmedicineimsj-8	94	32	%	%	NOUN
artofmedicineimsj-8	94	33	)	)	PUNCT
artofmedicineimsj-8	94	34	and	and	CCONJ
artofmedicineimsj-8	94	35	59	59	NUM
artofmedicineimsj-8	94	36	(	(	PUNCT
artofmedicineimsj-8	94	37	86.36	86.36	NUM
artofmedicineimsj-8	94	38	%	%	NOUN
artofmedicineimsj-8	94	39	)	)	PUNCT
artofmedicineimsj-8	94	40	patients	patient	NOUN
artofmedicineimsj-8	94	41	,	,	PUNCT
artofmedicineimsj-8	94	42	respectively	respectively	ADV
artofmedicineimsj-8	94	43	,	,	PUNCT
artofmedicineimsj-8	94	44	and	and	CCONJ
artofmedicineimsj-8	94	45	a	a	DET
artofmedicineimsj-8	94	46	low	low	ADJ
artofmedicineimsj-8	94	47	hdl	hdl	NOUN
artofmedicineimsj-8	94	48	level	level	NOUN
artofmedicineimsj-8	94	49	was	be	AUX
artofmedicineimsj-8	94	50	detected	detect	VERB
artofmedicineimsj-8	94	51	in	in	ADP
artofmedicineimsj-8	94	52	34	34	NUM
artofmedicineimsj-8	94	53	(	(	PUNCT
artofmedicineimsj-8	94	54	48.4	48.4	NUM
artofmedicineimsj-8	94	55	%	%	NOUN
artofmedicineimsj-8	94	56	)	)	PUNCT
artofmedicineimsj-8	94	57	of	of	ADP
artofmedicineimsj-8	94	58	patients	patient	NOUN
artofmedicineimsj-8	94	59	.	.	PUNCT
artofmedicineimsj-8	95	1	after	after	ADP
artofmedicineimsj-8	95	2	30	30	NUM
artofmedicineimsj-8	95	3	days	day	NOUN
artofmedicineimsj-8	95	4	of	of	ADP
artofmedicineimsj-8	95	5	treatment	treatment	NOUN
artofmedicineimsj-8	95	6	,	,	PUNCT
artofmedicineimsj-8	95	7	positive	positive	ADJ
artofmedicineimsj-8	95	8	dynamics	dynamic	NOUN
artofmedicineimsj-8	95	9	was	be	AUX
artofmedicineimsj-8	95	10	determined	determine	VERB
artofmedicineimsj-8	95	11	from	from	ADP
artofmedicineimsj-8	95	12	the	the	DET
artofmedicineimsj-8	95	13	side	side	NOUN
artofmedicineimsj-8	95	14	of	of	ADP
artofmedicineimsj-8	95	15	the	the	DET
artofmedicineimsj-8	95	16	blood	blood	NOUN
artofmedicineimsj-8	95	17	lipid	lipid	NOUN
artofmedicineimsj-8	95	18	profile	profile	NOUN
artofmedicineimsj-8	95	19	in	in	ADP
artofmedicineimsj-8	95	20	patients	patient	NOUN
artofmedicineimsj-8	95	21	of	of	ADP
artofmedicineimsj-8	95	22	both	both	DET
artofmedicineimsj-8	95	23	groups	group	NOUN
artofmedicineimsj-8	95	24	.	.	PUNCT
artofmedicineimsj-8	96	1	however	however	ADV
artofmedicineimsj-8	96	2	,	,	PUNCT
artofmedicineimsj-8	96	3	the	the	DET
artofmedicineimsj-8	96	4	most	most	ADV
artofmedicineimsj-8	96	5	pronounced	pronounced	ADJ
artofmedicineimsj-8	96	6	effect	effect	NOUN
artofmedicineimsj-8	96	7	was	be	AUX
artofmedicineimsj-8	96	8	observed	observe	VERB
artofmedicineimsj-8	96	9	in	in	ADP
artofmedicineimsj-8	96	10	the	the	DET
artofmedicineimsj-8	96	11	main	main	ADJ
artofmedicineimsj-8	96	12	group	group	NOUN
artofmedicineimsj-8	96	13	of	of	ADP
artofmedicineimsj-8	96	14	patients	patient	NOUN
artofmedicineimsj-8	96	15	receiving	receive	VERB
artofmedicineimsj-8	96	16	the	the	DET
artofmedicineimsj-8	96	17	combined	combine	VERB
artofmedicineimsj-8	96	18	drug	drug	NOUN
artofmedicineimsj-8	96	19	(	(	PUNCT
artofmedicineimsj-8	96	20	sacubitril	sacubitril	ADV
artofmedicineimsj-8	96	21	/	/	SYM
artofmedicineimsj-8	96	22	valsartan	valsartan	PROPN
artofmedicineimsj-8	96	23	)	)	PUNCT
artofmedicineimsj-8	96	24	(	(	PUNCT
artofmedicineimsj-8	96	25	table	table	NOUN
artofmedicineimsj-8	96	26	1	1	NUM
artofmedicineimsj-8	96	27	)	)	PUNCT
artofmedicineimsj-8	96	28	.	.	PUNCT
artofmedicineimsj-8	97	1	on	on	ADP
artofmedicineimsj-8	97	2	the	the	DET
artofmedicineimsj-8	97	3	table	table	NOUN
artofmedicineimsj-8	97	4	1	1	NUM
artofmedicineimsj-8	97	5	.	.	PUNCT
artofmedicineimsj-8	97	6	dynamics	dynamic	NOUN
artofmedicineimsj-8	97	7	of	of	ADP
artofmedicineimsj-8	97	8	blood	blood	NOUN
artofmedicineimsj-8	97	9	biochemical	biochemical	ADJ
artofmedicineimsj-8	97	10	parameters	parameter	NOUN
artofmedicineimsj-8	97	11	in	in	ADP
artofmedicineimsj-8	97	12	patients	patient	NOUN
artofmedicineimsj-8	97	13	with	with	ADP
artofmedicineimsj-8	97	14	chronic	chronic	ADJ
artofmedicineimsj-8	97	15	kidney	kidney	NOUN
artofmedicineimsj-8	97	16	disease	disease	NOUN
artofmedicineimsj-8	97	17	on	on	ADP
artofmedicineimsj-8	97	18	the	the	DET
artofmedicineimsj-8	97	19	background	background	NOUN
artofmedicineimsj-8	97	20	of	of	ADP
artofmedicineimsj-8	97	21	type	type	NOUN
artofmedicineimsj-8	97	22	2	2	NUM
artofmedicineimsj-8	97	23	diabetes	diabetes	NOUN
artofmedicineimsj-8	97	24	№	№	NUM
artofmedicineimsj-8	97	25	indicators	indicator	NOUN
artofmedicineimsj-8	97	26	group	group	NOUN
artofmedicineimsj-8	97	27	i	i	PRON
artofmedicineimsj-8	97	28	group	group	NOUN
artofmedicineimsj-8	97	29	ii	ii	PROPN
artofmedicineimsj-8	97	30	1st	1st	ADJ
artofmedicineimsj-8	97	31	day	day	NOUN
artofmedicineimsj-8	97	32	30th	30th	ADJ
artofmedicineimsj-8	97	33	day	day	NOUN
artofmedicineimsj-8	97	34	1st	1st	ADJ
artofmedicineimsj-8	97	35	day	day	NOUN
artofmedicineimsj-8	97	36	30th	30th	ADJ
artofmedicineimsj-8	97	37	day	day	NOUN
artofmedicineimsj-8	97	38	1	1	NUM
artofmedicineimsj-8	97	39	urea	urea	NOUN
artofmedicineimsj-8	97	40	,	,	PUNCT
artofmedicineimsj-8	97	41	mmol	mmol	NOUN
artofmedicineimsj-8	97	42	/	/	SYM
artofmedicineimsj-8	97	43	l	l	NOUN
artofmedicineimsj-8	97	44	12,4±0,51	12,4±0,51	NUM
artofmedicineimsj-8	97	45	9,03±0,71	9,03±0,71	NOUN
artofmedicineimsj-8	97	46	*	*	PROPN
artofmedicineimsj-8	97	47	*	*	X
artofmedicineimsj-8	97	48	11,6±0,83	11,6±0,83	NUM
artofmedicineimsj-8	97	49	9,6±1,56	9,6±1,56	NUM
artofmedicineimsj-8	97	50	*	*	SYM
artofmedicineimsj-8	97	51	2	2	NUM
artofmedicineimsj-8	97	52	creatinine	creatinine	NOUN
artofmedicineimsj-8	97	53	,	,	PUNCT
artofmedicineimsj-8	97	54	mmol	mmol	NOUN
artofmedicineimsj-8	97	55	/	/	SYM
artofmedicineimsj-8	97	56	l	l	NOUN
artofmedicineimsj-8	97	57	163,4±12,3	163,4±12,3	NUM
artofmedicineimsj-8	97	58	1	1	NUM
artofmedicineimsj-8	97	59	142,6±8,5	142,6±8,5	NUM
artofmedicineimsj-8	97	60	*	*	PUNCT
artofmedicineimsj-8	97	61	*	*	PUNCT
artofmedicineimsj-8	97	62	159,6±7,81	159,6±7,81	NUM
artofmedicineimsj-8	97	63	150,8±6,04	150,8±6,04	NUM
artofmedicineimsj-8	97	64	*	*	SYM
artofmedicineimsj-8	97	65	3	3	NUM
artofmedicineimsj-8	97	66	total	total	ADJ
artofmedicineimsj-8	97	67	cholesterol	cholesterol	NOUN
artofmedicineimsj-8	97	68	,	,	PUNCT
artofmedicineimsj-8	97	69	mmol	mmol	NOUN
artofmedicineimsj-8	97	70	/	/	SYM
artofmedicineimsj-8	97	71	l	l	NOUN
artofmedicineimsj-8	97	72	6,38±0,43	6,38±0,43	NUM
artofmedicineimsj-8	97	73	5,71±0,13	5,71±0,13	NUM
artofmedicineimsj-8	97	74	*	*	PUNCT
artofmedicineimsj-8	97	75	6,29±0,39	6,29±0,39	NOUN
artofmedicineimsj-8	98	1	5,91±0,18	5,91±0,18	NOUN
artofmedicineimsj-8	98	2	*	*	SYM
artofmedicineimsj-8	98	3	4	4	NUM
artofmedicineimsj-8	98	4	tg	tg	PROPN
artofmedicineimsj-8	98	5	mmol	mmol	NOUN
artofmedicineimsj-8	98	6	/	/	SYM
artofmedicineimsj-8	98	7	l	l	NOUN
artofmedicineimsj-8	98	8	2,32±0,45	2,32±0,45	NUM
artofmedicineimsj-8	98	9	1,65±0,23	1,65±0,23	NUM
artofmedicineimsj-8	98	10	*	*	PUNCT
artofmedicineimsj-8	98	11	*	*	PUNCT
artofmedicineimsj-8	99	1	2,29±0,31	2,29±0,31	NUM
artofmedicineimsj-8	99	2	1,78±0,27	1,78±0,27	NUM
artofmedicineimsj-8	99	3	*	*	SYM
artofmedicineimsj-8	99	4	5	5	NUM
artofmedicineimsj-8	99	5	ldl	ldl	NOUN
artofmedicineimsj-8	99	6	mmol	mmol	NOUN
artofmedicineimsj-8	99	7	/	/	SYM
artofmedicineimsj-8	99	8	l	l	NOUN
artofmedicineimsj-8	99	9	4,1±1,12	4,1±1,12	NUM
artofmedicineimsj-8	99	10	3,18±0,32	3,18±0,32	NUM
artofmedicineimsj-8	99	11	*	*	PUNCT
artofmedicineimsj-8	99	12	*	*	PUNCT
artofmedicineimsj-8	99	13	4,22±1,24	4,22±1,24	PROPN
artofmedicineimsj-8	100	1	3,32±0,31	3,32±0,31	NUM
artofmedicineimsj-8	100	2	*	*	SYM
artofmedicineimsj-8	100	3	6	6	NUM
artofmedicineimsj-8	100	4	hdl	hdl	PROPN
artofmedicineimsj-8	100	5	mmol	mmol	PROPN
artofmedicineimsj-8	100	6	/	/	SYM
artofmedicineimsj-8	100	7	l	l	NOUN
artofmedicineimsj-8	100	8	1,09±0,25	1,09±0,25	NUM
artofmedicineimsj-8	101	1	1,22±0,32	1,22±0,32	NUM
artofmedicineimsj-8	101	2	1,07±0,31	1,07±0,31	NUM
artofmedicineimsj-8	101	3	1,18±0,26	1,18±0,26	ADJ
artofmedicineimsj-8	101	4	art	art	NOUN
artofmedicineimsj-8	101	5	of	of	ADP
artofmedicineimsj-8	101	6	medicine	medicine	NOUN
artofmedicineimsj-8	101	7	international	international	ADJ
artofmedicineimsj-8	101	8	medical	medical	ADJ
artofmedicineimsj-8	101	9	scientific	scientific	ADJ
artofmedicineimsj-8	101	10	journal	journal	NOUN
artofmedicineimsj-8	101	11	volume-1	volume-1	PROPN
artofmedicineimsj-8	101	12	issue-1	issue-1	PROPN
artofmedicineimsj-8	101	13	8	8	NUM
artofmedicineimsj-8	101	14	background	background	NOUN
artofmedicineimsj-8	101	15	of	of	ADP
artofmedicineimsj-8	101	16	treatment	treatment	NOUN
artofmedicineimsj-8	101	17	with	with	ADP
artofmedicineimsj-8	101	18	sacubitril	sacubitril	ADJ
artofmedicineimsj-8	101	19	/	/	SYM
artofmedicineimsj-8	101	20	valsartan	valsartan	ADJ
artofmedicineimsj-8	101	21	in	in	ADP
artofmedicineimsj-8	101	22	the	the	DET
artofmedicineimsj-8	101	23	first	first	ADJ
artofmedicineimsj-8	101	24	group	group	NOUN
artofmedicineimsj-8	101	25	,	,	PUNCT
artofmedicineimsj-8	101	26	the	the	DET
artofmedicineimsj-8	101	27	level	level	NOUN
artofmedicineimsj-8	101	28	of	of	ADP
artofmedicineimsj-8	101	29	cholesterol	cholesterol	NOUN
artofmedicineimsj-8	101	30	,	,	PUNCT
artofmedicineimsj-8	101	31	ldl	ldl	NOUN
artofmedicineimsj-8	101	32	,	,	PUNCT
artofmedicineimsj-8	101	33	tg	tg	PROPN
artofmedicineimsj-8	101	34	decreased	decrease	VERB
artofmedicineimsj-8	101	35	by	by	ADP
artofmedicineimsj-8	101	36	10.5	10.5	NUM
artofmedicineimsj-8	101	37	%	%	NOUN
artofmedicineimsj-8	101	38	(	(	PUNCT
artofmedicineimsj-8	101	39	p	p	X
artofmedicineimsj-8	101	40	<	<	X
artofmedicineimsj-8	101	41	0.05	0.05	NUM
artofmedicineimsj-8	101	42	)	)	PUNCT
artofmedicineimsj-8	101	43	,	,	PUNCT
artofmedicineimsj-8	101	44	22.4	22.4	NUM
artofmedicineimsj-8	101	45	%	%	NOUN
artofmedicineimsj-8	101	46	and	and	CCONJ
artofmedicineimsj-8	101	47	28.87	28.87	NUM
artofmedicineimsj-8	101	48	%	%	NOUN
artofmedicineimsj-8	101	49	,	,	PUNCT
artofmedicineimsj-8	101	50	respectively	respectively	ADV
artofmedicineimsj-8	101	51	,	,	PUNCT
artofmedicineimsj-8	101	52	compared	compare	VERB
artofmedicineimsj-8	101	53	with	with	ADP
artofmedicineimsj-8	101	54	their	their	PRON
artofmedicineimsj-8	101	55	initial	initial	ADJ
artofmedicineimsj-8	101	56	levels	level	NOUN
artofmedicineimsj-8	101	57	(	(	PUNCT
artofmedicineimsj-8	101	58	p	p	X
artofmedicineimsj-8	101	59	<	<	X
artofmedicineimsj-8	101	60	0	0	NUM
artofmedicineimsj-8	101	61	,	,	PUNCT
artofmedicineimsj-8	101	62	01	01	NUM
artofmedicineimsj-8	101	63	)	)	PUNCT
artofmedicineimsj-8	101	64	.	.	PUNCT
artofmedicineimsj-8	102	1	in	in	ADP
artofmedicineimsj-8	102	2	the	the	DET
artofmedicineimsj-8	102	3	2nd	2nd	ADJ
artofmedicineimsj-8	102	4	group	group	NOUN
artofmedicineimsj-8	102	5	,	,	PUNCT
artofmedicineimsj-8	102	6	receiving	receive	VERB
artofmedicineimsj-8	102	7	valsartan	valsartan	PROPN
artofmedicineimsj-8	102	8	,	,	PUNCT
artofmedicineimsj-8	102	9	similar	similar	ADJ
artofmedicineimsj-8	102	10	indicators	indicator	NOUN
artofmedicineimsj-8	102	11	were	be	AUX
artofmedicineimsj-8	102	12	:	:	PUNCT
artofmedicineimsj-8	102	13	6.04	6.04	NUM
artofmedicineimsj-8	102	14	%	%	NOUN
artofmedicineimsj-8	102	15	,	,	PUNCT
artofmedicineimsj-8	102	16	21.3	21.3	NUM
artofmedicineimsj-8	102	17	%	%	NOUN
artofmedicineimsj-8	102	18	and	and	CCONJ
artofmedicineimsj-8	102	19	22.27	22.27	NUM
artofmedicineimsj-8	102	20	%	%	NOUN
artofmedicineimsj-8	102	21	(	(	PUNCT
artofmedicineimsj-8	102	22	p	p	X
artofmedicineimsj-8	102	23	<	<	NOUN
artofmedicineimsj-8	102	24	0.05	0.05	NUM
artofmedicineimsj-8	102	25	)	)	PUNCT
artofmedicineimsj-8	102	26	(	(	PUNCT
artofmedicineimsj-8	102	27	table	table	NOUN
artofmedicineimsj-8	102	28	1	1	NUM
artofmedicineimsj-8	102	29	)	)	PUNCT
artofmedicineimsj-8	102	30	.	.	PUNCT
artofmedicineimsj-8	103	1	the	the	DET
artofmedicineimsj-8	103	2	data	datum	NOUN
artofmedicineimsj-8	103	3	obtained	obtain	VERB
artofmedicineimsj-8	103	4	indicate	indicate	VERB
artofmedicineimsj-8	103	5	a	a	DET
artofmedicineimsj-8	103	6	more	more	ADV
artofmedicineimsj-8	103	7	reliable	reliable	ADJ
artofmedicineimsj-8	103	8	change	change	NOUN
artofmedicineimsj-8	103	9	in	in	ADP
artofmedicineimsj-8	103	10	the	the	DET
artofmedicineimsj-8	103	11	lipid	lipid	NOUN
artofmedicineimsj-8	103	12	spectrum	spectrum	NOUN
artofmedicineimsj-8	103	13	in	in	ADP
artofmedicineimsj-8	103	14	the	the	DET
artofmedicineimsj-8	103	15	1st	1st	ADJ
artofmedicineimsj-8	103	16	group	group	NOUN
artofmedicineimsj-8	103	17	,	,	PUNCT
artofmedicineimsj-8	103	18	who	who	PRON
artofmedicineimsj-8	103	19	took	take	VERB
artofmedicineimsj-8	103	20	the	the	DET
artofmedicineimsj-8	103	21	combined	combine	VERB
artofmedicineimsj-8	103	22	drug	drug	NOUN
artofmedicineimsj-8	103	23	sacubitril	sacubitril	NOUN
artofmedicineimsj-8	103	24	/	/	SYM
artofmedicineimsj-8	103	25	valsartan	valsartan	ADJ
artofmedicineimsj-8	103	26	,	,	PUNCT
artofmedicineimsj-8	103	27	in	in	ADP
artofmedicineimsj-8	103	28	relation	relation	NOUN
artofmedicineimsj-8	103	29	to	to	ADP
artofmedicineimsj-8	103	30	the	the	DET
artofmedicineimsj-8	103	31	parameters	parameter	NOUN
artofmedicineimsj-8	103	32	of	of	ADP
artofmedicineimsj-8	103	33	cholesterol	cholesterol	NOUN
artofmedicineimsj-8	103	34	,	,	PUNCT
artofmedicineimsj-8	103	35	ldl	ldl	NOUN
artofmedicineimsj-8	103	36	and	and	CCONJ
artofmedicineimsj-8	103	37	tg	tg	PROPN
artofmedicineimsj-8	103	38	in	in	ADP
artofmedicineimsj-8	103	39	the	the	DET
artofmedicineimsj-8	103	40	blood	blood	NOUN
artofmedicineimsj-8	103	41	serum	serum	NOUN
artofmedicineimsj-8	103	42	compared	compare	VERB
artofmedicineimsj-8	103	43	with	with	ADP
artofmedicineimsj-8	103	44	valsartan	valsartan	PROPN
artofmedicineimsj-8	103	45	therapy	therapy	NOUN
artofmedicineimsj-8	103	46	(	(	PUNCT
artofmedicineimsj-8	103	47	table	table	NOUN
artofmedicineimsj-8	103	48	1	1	NUM
artofmedicineimsj-8	103	49	)	)	PUNCT
artofmedicineimsj-8	103	50	.	.	PUNCT
artofmedicineimsj-8	104	1	based	base	VERB
artofmedicineimsj-8	104	2	on	on	ADP
artofmedicineimsj-8	104	3	the	the	DET
artofmedicineimsj-8	104	4	biochemical	biochemical	ADJ
artofmedicineimsj-8	104	5	parameters	parameter	NOUN
artofmedicineimsj-8	104	6	of	of	ADP
artofmedicineimsj-8	104	7	the	the	DET
artofmedicineimsj-8	104	8	blood	blood	NOUN
artofmedicineimsj-8	104	9	,	,	PUNCT
artofmedicineimsj-8	104	10	the	the	DET
artofmedicineimsj-8	104	11	gfr	gfr	NOUN
artofmedicineimsj-8	104	12	of	of	ADP
artofmedicineimsj-8	104	13	both	both	DET
artofmedicineimsj-8	104	14	groups	group	NOUN
artofmedicineimsj-8	104	15	was	be	AUX
artofmedicineimsj-8	104	16	calculated	calculate	VERB
artofmedicineimsj-8	104	17	.	.	PUNCT
artofmedicineimsj-8	105	1	before	before	ADP
artofmedicineimsj-8	105	2	treatment	treatment	NOUN
artofmedicineimsj-8	105	3	,	,	PUNCT
artofmedicineimsj-8	105	4	in	in	ADP
artofmedicineimsj-8	105	5	group	group	NOUN
artofmedicineimsj-8	105	6	i	i	PRON
artofmedicineimsj-8	105	7	patients	patient	NOUN
artofmedicineimsj-8	105	8	,	,	PUNCT
artofmedicineimsj-8	105	9	this	this	DET
artofmedicineimsj-8	105	10	indicator	indicator	NOUN
artofmedicineimsj-8	105	11	was	be	AUX
artofmedicineimsj-8	105	12	45.4	45.4	NUM
artofmedicineimsj-8	105	13	±	±	NUM
artofmedicineimsj-8	105	14	8.5	8.5	NUM
artofmedicineimsj-8	105	15	ml	ml	NOUN
artofmedicineimsj-8	105	16	/	/	SYM
artofmedicineimsj-8	105	17	min	min	PROPN
artofmedicineimsj-8	105	18	/	/	SYM
artofmedicineimsj-8	105	19	1.73	1.73	NUM
artofmedicineimsj-8	105	20	m2	m2	PROPN
artofmedicineimsj-8	105	21	,	,	PUNCT
artofmedicineimsj-8	105	22	and	and	CCONJ
artofmedicineimsj-8	105	23	in	in	ADP
artofmedicineimsj-8	105	24	group	group	PROPN
artofmedicineimsj-8	105	25	ii	ii	PROPN
artofmedicineimsj-8	105	26	,	,	PUNCT
artofmedicineimsj-8	105	27	43.4	43.4	NUM
artofmedicineimsj-8	105	28	±	±	NUM
artofmedicineimsj-8	105	29	7.5	7.5	NUM
artofmedicineimsj-8	105	30	ml	ml	NOUN
artofmedicineimsj-8	105	31	/	/	SYM
artofmedicineimsj-8	105	32	min	min	PROPN
artofmedicineimsj-8	105	33	/	/	SYM
artofmedicineimsj-8	105	34	1.73	1.73	NUM
artofmedicineimsj-8	105	35	m2	m2	NOUN
artofmedicineimsj-8	105	36	,	,	PUNCT
artofmedicineimsj-8	105	37	respectively	respectively	ADV
artofmedicineimsj-8	105	38	.	.	PUNCT
artofmedicineimsj-8	106	1	on	on	ADP
artofmedicineimsj-8	106	2	the	the	DET
artofmedicineimsj-8	106	3	30th	30th	ADJ
artofmedicineimsj-8	106	4	day	day	NOUN
artofmedicineimsj-8	106	5	of	of	ADP
artofmedicineimsj-8	106	6	treatment	treatment	NOUN
artofmedicineimsj-8	106	7	,	,	PUNCT
artofmedicineimsj-8	106	8	there	there	PRON
artofmedicineimsj-8	106	9	was	be	VERB
artofmedicineimsj-8	106	10	a	a	DET
artofmedicineimsj-8	106	11	significant	significant	ADJ
artofmedicineimsj-8	106	12	change	change	NOUN
artofmedicineimsj-8	106	13	in	in	ADP
artofmedicineimsj-8	106	14	these	these	DET
artofmedicineimsj-8	106	15	indicators	indicator	NOUN
artofmedicineimsj-8	106	16	with	with	ADP
artofmedicineimsj-8	106	17	positive	positive	ADJ
artofmedicineimsj-8	106	18	dynamics	dynamic	NOUN
artofmedicineimsj-8	106	19	with	with	ADP
artofmedicineimsj-8	106	20	a	a	DET
artofmedicineimsj-8	106	21	significant	significant	ADJ
artofmedicineimsj-8	106	22	difference	difference	NOUN
artofmedicineimsj-8	106	23	between	between	ADP
artofmedicineimsj-8	106	24	the	the	DET
artofmedicineimsj-8	106	25	groups	group	NOUN
artofmedicineimsj-8	106	26	.	.	PUNCT
artofmedicineimsj-8	107	1	in	in	ADP
artofmedicineimsj-8	107	2	patients	patient	NOUN
artofmedicineimsj-8	107	3	receiving	receive	VERB
artofmedicineimsj-8	107	4	sacubitril	sacubitril	ADJ
artofmedicineimsj-8	107	5	/	/	SYM
artofmedicineimsj-8	107	6	valsartan	valsartan	ADJ
artofmedicineimsj-8	107	7	,	,	PUNCT
artofmedicineimsj-8	107	8	gfr	gfr	NOUN
artofmedicineimsj-8	107	9	improved	improve	VERB
artofmedicineimsj-8	107	10	by	by	ADP
artofmedicineimsj-8	107	11	65.4	65.4	NUM
artofmedicineimsj-8	107	12	±	±	NUM
artofmedicineimsj-8	107	13	7.5	7.5	NUM
artofmedicineimsj-8	107	14	ml	ml	NOUN
artofmedicineimsj-8	107	15	/	/	SYM
artofmedicineimsj-8	107	16	min	min	PROPN
artofmedicineimsj-8	107	17	/	/	SYM
artofmedicineimsj-8	107	18	1.73	1.73	NUM
artofmedicineimsj-8	107	19	m2	m2	PROPN
artofmedicineimsj-8	107	20	(	(	PUNCT
artofmedicineimsj-8	107	21	p	p	X
artofmedicineimsj-8	107	22	<	<	X
artofmedicineimsj-8	107	23	0.01	0.01	NUM
artofmedicineimsj-8	107	24	)	)	PUNCT
artofmedicineimsj-8	107	25	,	,	PUNCT
artofmedicineimsj-8	107	26	and	and	CCONJ
artofmedicineimsj-8	107	27	in	in	ADP
artofmedicineimsj-8	107	28	the	the	DET
artofmedicineimsj-8	107	29	group	group	NOUN
artofmedicineimsj-8	107	30	of	of	ADP
artofmedicineimsj-8	107	31	patients	patient	NOUN
artofmedicineimsj-8	107	32	taking	take	VERB
artofmedicineimsj-8	107	33	valsartan	valsartan	VERB
artofmedicineimsj-8	107	34	by	by	ADP
artofmedicineimsj-8	107	35	60.6	60.6	NUM
artofmedicineimsj-8	107	36	±	±	NUM
artofmedicineimsj-8	107	37	5.2	5.2	NUM
artofmedicineimsj-8	107	38	ml	ml	NOUN
artofmedicineimsj-8	107	39	/	/	SYM
artofmedicineimsj-8	107	40	min	min	PROPN
artofmedicineimsj-8	107	41	/	/	SYM
artofmedicineimsj-8	107	42	1.73	1.73	NUM
artofmedicineimsj-8	107	43	m2	m2	PROPN
artofmedicineimsj-8	107	44	(	(	PUNCT
artofmedicineimsj-8	107	45	p	p	X
artofmedicineimsj-8	107	46	<	<	X
artofmedicineimsj-8	107	47	0.05	0.05	NUM
artofmedicineimsj-8	107	48	)	)	PUNCT
artofmedicineimsj-8	107	49	.	.	PUNCT
artofmedicineimsj-8	108	1	the	the	DET
artofmedicineimsj-8	108	2	30	30	NUM
artofmedicineimsj-8	108	3	-	-	PUNCT
artofmedicineimsj-8	108	4	day	day	NOUN
artofmedicineimsj-8	108	5	course	course	NOUN
artofmedicineimsj-8	108	6	of	of	ADP
artofmedicineimsj-8	108	7	treatment	treatment	NOUN
artofmedicineimsj-8	108	8	showed	show	VERB
artofmedicineimsj-8	108	9	that	that	SCONJ
artofmedicineimsj-8	108	10	in	in	ADP
artofmedicineimsj-8	108	11	the	the	DET
artofmedicineimsj-8	108	12	first	first	ADJ
artofmedicineimsj-8	108	13	group	group	NOUN
artofmedicineimsj-8	108	14	the	the	DET
artofmedicineimsj-8	108	15	gfr	gfr	NOUN
artofmedicineimsj-8	108	16	increased	increase	VERB
artofmedicineimsj-8	108	17	by	by	ADP
artofmedicineimsj-8	108	18	44.05	44.05	NUM
artofmedicineimsj-8	108	19	%	%	NOUN
artofmedicineimsj-8	108	20	,	,	PUNCT
artofmedicineimsj-8	108	21	and	and	CCONJ
artofmedicineimsj-8	108	22	in	in	ADP
artofmedicineimsj-8	108	23	the	the	DET
artofmedicineimsj-8	108	24	second	second	ADJ
artofmedicineimsj-8	108	25	group	group	NOUN
artofmedicineimsj-8	108	26	by	by	ADP
artofmedicineimsj-8	108	27	39.6	39.6	NUM
artofmedicineimsj-8	108	28	%	%	NOUN
artofmedicineimsj-8	108	29	compared	compare	VERB
artofmedicineimsj-8	108	30	with	with	ADP
artofmedicineimsj-8	108	31	the	the	DET
artofmedicineimsj-8	108	32	initial	initial	ADJ
artofmedicineimsj-8	108	33	values	value	NOUN
artofmedicineimsj-8	108	34	,	,	PUNCT
artofmedicineimsj-8	108	35	respectively	respectively	ADV
artofmedicineimsj-8	108	36	.	.	PUNCT
artofmedicineimsj-8	109	1	correlation	correlation	NOUN
artofmedicineimsj-8	109	2	analysis	analysis	NOUN
artofmedicineimsj-8	109	3	revealed	reveal	VERB
artofmedicineimsj-8	109	4	a	a	DET
artofmedicineimsj-8	109	5	close	close	ADJ
artofmedicineimsj-8	109	6	proportional	proportional	ADJ
artofmedicineimsj-8	109	7	relationship	relationship	NOUN
artofmedicineimsj-8	109	8	between	between	ADP
artofmedicineimsj-8	109	9	gfr	gfr	PROPN
artofmedicineimsj-8	109	10	and	and	CCONJ
artofmedicineimsj-8	109	11	the	the	DET
artofmedicineimsj-8	109	12	levels	level	NOUN
artofmedicineimsj-8	109	13	of	of	ADP
artofmedicineimsj-8	109	14	tc	tc	NOUN
artofmedicineimsj-8	109	15	,	,	PUNCT
artofmedicineimsj-8	109	16	ldl	ldl	NOUN
artofmedicineimsj-8	109	17	,	,	PUNCT
artofmedicineimsj-8	109	18	tg	tg	PROPN
artofmedicineimsj-8	109	19	,	,	PUNCT
artofmedicineimsj-8	109	20	respectively	respectively	ADV
artofmedicineimsj-8	109	21	(	(	PUNCT
artofmedicineimsj-8	109	22	r=0,68	r=0,68	PROPN
artofmedicineimsj-8	109	23	,	,	PUNCT
artofmedicineimsj-8	109	24	r=0,26	r=0,26	PROPN
artofmedicineimsj-8	109	25	)	)	PUNCT
artofmedicineimsj-8	109	26	.	.	PUNCT
artofmedicineimsj-8	110	1	the	the	DET
artofmedicineimsj-8	110	2	above	above	ADV
artofmedicineimsj-8	110	3	mentioned	mention	VERB
artofmedicineimsj-8	110	4	gfr	gfr	NOUN
artofmedicineimsj-8	110	5	changes	change	NOUN
artofmedicineimsj-8	110	6	are	be	AUX
artofmedicineimsj-8	110	7	provided	provide	VERB
artofmedicineimsj-8	110	8	in	in	ADP
artofmedicineimsj-8	110	9	the	the	DET
artofmedicineimsj-8	110	10	form	form	NOUN
artofmedicineimsj-8	110	11	of	of	ADP
artofmedicineimsj-8	110	12	this	this	DET
artofmedicineimsj-8	110	13	diagram	diagram	NOUN
artofmedicineimsj-8	110	14	:	:	PUNCT
artofmedicineimsj-8	110	15	diagram	diagram	NOUN
artofmedicineimsj-8	110	16	1	1	NUM
artofmedicineimsj-8	110	17	.	.	PUNCT
artofmedicineimsj-8	111	1	gfr	gfr	NOUN
artofmedicineimsj-8	111	2	indices	index	NOUN
artofmedicineimsj-8	111	3	in	in	ADP
artofmedicineimsj-8	111	4	patients	patient	NOUN
artofmedicineimsj-8	111	5	with	with	ADP
artofmedicineimsj-8	111	6	chronic	chronic	ADJ
artofmedicineimsj-8	111	7	kidney	kidney	NOUN
artofmedicineimsj-8	111	8	disease	disease	NOUN
artofmedicineimsj-8	111	9	with	with	ADP
artofmedicineimsj-8	111	10	type	type	NOUN
artofmedicineimsj-8	111	11	2	2	NUM
artofmedicineimsj-8	111	12	diabetes	diabetes	NOUN
artofmedicineimsj-8	111	13	note	note	NOUN
artofmedicineimsj-8	111	14	:	:	PUNCT
artofmedicineimsj-8	111	15	delivery	delivery	NOUN
artofmedicineimsj-8	111	16	*	*	PUNCT
artofmedicineimsj-8	112	1	р<0.05	р<0.05	PROPN
artofmedicineimsj-8	112	2	.	.	PUNCT
artofmedicineimsj-8	113	1	*	*	PUNCT
artofmedicineimsj-8	113	2	*	*	PUNCT
artofmedicineimsj-8	113	3	р<0.01	р<0.01	VERB
artofmedicineimsj-8	113	4	thus	thus	ADV
artofmedicineimsj-8	113	5	,	,	PUNCT
artofmedicineimsj-8	113	6	the	the	DET
artofmedicineimsj-8	113	7	study	study	NOUN
artofmedicineimsj-8	113	8	of	of	ADP
artofmedicineimsj-8	113	9	the	the	DET
artofmedicineimsj-8	113	10	functional	functional	ADJ
artofmedicineimsj-8	113	11	state	state	NOUN
artofmedicineimsj-8	113	12	of	of	ADP
artofmedicineimsj-8	113	13	the	the	DET
artofmedicineimsj-8	113	14	kidneys	kidney	NOUN
artofmedicineimsj-8	113	15	and	and	CCONJ
artofmedicineimsj-8	113	16	the	the	DET
artofmedicineimsj-8	113	17	blood	blood	NOUN
artofmedicineimsj-8	113	18	lipid	lipid	NOUN
artofmedicineimsj-8	113	19	spectrum	spectrum	NOUN
artofmedicineimsj-8	113	20	in	in	ADP
artofmedicineimsj-8	113	21	type	type	NOUN
artofmedicineimsj-8	113	22	2	2	NUM
artofmedicineimsj-8	113	23	diabetes	diabetes	NOUN
artofmedicineimsj-8	113	24	mellitus	mellitus	NOUN
artofmedicineimsj-8	113	25	with	with	ADP
artofmedicineimsj-8	113	26	chronic	chronic	ADJ
artofmedicineimsj-8	113	27	kidney	kidney	NOUN
artofmedicineimsj-8	113	28	disease	disease	NOUN
artofmedicineimsj-8	113	29	,	,	PUNCT
artofmedicineimsj-8	113	30	there	there	PRON
artofmedicineimsj-8	113	31	was	be	VERB
artofmedicineimsj-8	113	32	an	an	DET
artofmedicineimsj-8	113	33	improvement	improvement	NOUN
artofmedicineimsj-8	113	34	in	in	ADP
artofmedicineimsj-8	113	35	renal	renal	ADJ
artofmedicineimsj-8	113	36	dysfunction	dysfunction	NOUN
artofmedicineimsj-8	113	37	and	and	CCONJ
artofmedicineimsj-8	113	38	blood	blood	NOUN
artofmedicineimsj-8	113	39	dyslipidemia	dyslipidemia	NOUN
artofmedicineimsj-8	113	40	in	in	ADP
artofmedicineimsj-8	113	41	patients	patient	NOUN
artofmedicineimsj-8	113	42	taking	take	VERB
artofmedicineimsj-8	113	43	sacubitrile	sacubitrile	ADV
artofmedicineimsj-8	113	44	/	/	PUNCT
artofmedicineimsj-8	113	45	valsartan	valsartan	PROPN
artofmedicineimsj-8	113	46	compared	compare	VERB
artofmedicineimsj-8	113	47	with	with	ADP
artofmedicineimsj-8	113	48	valsartan	valsartan	PROPN
artofmedicineimsj-8	113	49	.	.	PUNCT
artofmedicineimsj-8	114	1	conclusion	conclusion	NOUN
artofmedicineimsj-8	114	2	:	:	PUNCT
artofmedicineimsj-8	114	3	1	1	X
artofmedicineimsj-8	114	4	.	.	X
artofmedicineimsj-8	115	1	in	in	ADP
artofmedicineimsj-8	115	2	all	all	DET
artofmedicineimsj-8	115	3	groups	group	NOUN
artofmedicineimsj-8	115	4	of	of	ADP
artofmedicineimsj-8	115	5	examined	examine	VERB
artofmedicineimsj-8	115	6	patients	patient	NOUN
artofmedicineimsj-8	115	7	,	,	PUNCT
artofmedicineimsj-8	115	8	an	an	DET
artofmedicineimsj-8	115	9	improvement	improvement	NOUN
artofmedicineimsj-8	115	10	in	in	ADP
artofmedicineimsj-8	115	11	the	the	DET
artofmedicineimsj-8	115	12	functional	functional	ADJ
artofmedicineimsj-8	115	13	state	state	NOUN
artofmedicineimsj-8	115	14	of	of	ADP
artofmedicineimsj-8	115	15	the	the	DET
artofmedicineimsj-8	115	16	kidneys	kidney	NOUN
artofmedicineimsj-8	115	17	was	be	AUX
artofmedicineimsj-8	115	18	noted	note	VERB
artofmedicineimsj-8	115	19	,	,	PUNCT
artofmedicineimsj-8	115	20	however	however	ADV
artofmedicineimsj-8	115	21	,	,	PUNCT
artofmedicineimsj-8	115	22	the	the	DET
artofmedicineimsj-8	115	23	nephroprotective	nephroprotective	ADJ
artofmedicineimsj-8	115	24	effect	effect	NOUN
artofmedicineimsj-8	115	25	was	be	AUX
artofmedicineimsj-8	115	26	more	more	ADV
artofmedicineimsj-8	115	27	pronounced	pronounce	VERB
artofmedicineimsj-8	115	28	in	in	ADP
artofmedicineimsj-8	115	29	the	the	DET
artofmedicineimsj-8	115	30	group	group	NOUN
artofmedicineimsj-8	115	31	of	of	ADP
artofmedicineimsj-8	115	32	patients	patient	NOUN
artofmedicineimsj-8	115	33	taking	take	VERB
artofmedicineimsj-8	115	34	sacubitril	sacubitril	ADV
artofmedicineimsj-8	115	35	/	/	SYM
artofmedicineimsj-8	115	36	valsartan	valsartan	ADJ
artofmedicineimsj-8	115	37	,	,	PUNCT
artofmedicineimsj-8	115	38	in	in	ADP
artofmedicineimsj-8	115	39	comparison	comparison	NOUN
artofmedicineimsj-8	115	40	with	with	ADP
artofmedicineimsj-8	115	41	the	the	DET
artofmedicineimsj-8	115	42	group	group	NOUN
artofmedicineimsj-8	115	43	receiving	receive	VERB
artofmedicineimsj-8	115	44	valsartan	valsartan	PROPN
artofmedicineimsj-8	115	45	with	with	ADP
artofmedicineimsj-8	115	46	a	a	DET
artofmedicineimsj-8	115	47	comparable	comparable	ADJ
artofmedicineimsj-8	115	48	effect	effect	NOUN
artofmedicineimsj-8	115	49	of	of	ADP
artofmedicineimsj-8	115	50	equivalent	equivalent	ADJ
artofmedicineimsj-8	115	51	doses	dose	NOUN
artofmedicineimsj-8	115	52	of	of	ADP
artofmedicineimsj-8	115	53	these	these	DET
artofmedicineimsj-8	115	54	drugs	drug	NOUN
artofmedicineimsj-8	115	55	.	.	PUNCT
artofmedicineimsj-8	116	1	0	0	NUM
artofmedicineimsj-8	116	2	10	10	NUM
artofmedicineimsj-8	116	3	20	20	NUM
artofmedicineimsj-8	116	4	30	30	NUM
artofmedicineimsj-8	116	5	40	40	NUM
artofmedicineimsj-8	116	6	50	50	NUM
artofmedicineimsj-8	116	7	60	60	NUM
artofmedicineimsj-8	116	8	70	70	NUM
artofmedicineimsj-8	116	9	80	80	NUM
artofmedicineimsj-8	116	10	1st	1st	ADJ
artofmedicineimsj-8	116	11	day	day	NOUN
artofmedicineimsj-8	116	12	30th	30th	ADJ
artofmedicineimsj-8	116	13	day	day	NOUN
artofmedicineimsj-8	117	1	45,4	45,4	NUM
artofmedicineimsj-8	117	2	65,4	65,4	NUM
artofmedicineimsj-8	118	1	43,4	43,4	ADJ
artofmedicineimsj-8	118	2	60,6	60,6	NUM
artofmedicineimsj-8	118	3	group	group	NOUN
artofmedicineimsj-8	118	4	i	i	PRON
artofmedicineimsj-8	118	5	group	group	PROPN
artofmedicineimsj-8	118	6	ii	ii	PROPN
artofmedicineimsj-8	118	7	volume-1	volume-1	PROPN
artofmedicineimsj-8	118	8	issue-1	issue-1	PROPN
artofmedicineimsj-8	118	9	art	art	NOUN
artofmedicineimsj-8	118	10	of	of	ADP
artofmedicineimsj-8	118	11	medicine	medicine	NOUN
artofmedicineimsj-8	118	12	international	international	ADJ
artofmedicineimsj-8	118	13	medical	medical	ADJ
artofmedicineimsj-8	118	14	scientific	scientific	ADJ
artofmedicineimsj-8	118	15	journal	journal	NOUN
artofmedicineimsj-8	118	16	9	9	NUM
artofmedicineimsj-8	118	17	2	2	NUM
artofmedicineimsj-8	118	18	.	.	PUNCT
artofmedicineimsj-8	119	1	through	through	ADP
artofmedicineimsj-8	119	2	justified	justified	ADJ
artofmedicineimsj-8	119	3	pharmacotherapy	pharmacotherapy	NOUN
artofmedicineimsj-8	119	4	with	with	ADP
artofmedicineimsj-8	119	5	sacubitril	sacubitril	ADJ
artofmedicineimsj-8	119	6	/	/	SYM
artofmedicineimsj-8	119	7	valsartan	valsartan	PROPN
artofmedicineimsj-8	119	8	,	,	PUNCT
artofmedicineimsj-8	119	9	it	it	PRON
artofmedicineimsj-8	119	10	is	be	AUX
artofmedicineimsj-8	119	11	possible	possible	ADJ
artofmedicineimsj-8	119	12	to	to	PART
artofmedicineimsj-8	119	13	influence	influence	VERB
artofmedicineimsj-8	119	14	not	not	PART
artofmedicineimsj-8	119	15	only	only	ADV
artofmedicineimsj-8	119	16	the	the	DET
artofmedicineimsj-8	119	17	mechanisms	mechanism	NOUN
artofmedicineimsj-8	119	18	of	of	ADP
artofmedicineimsj-8	119	19	renal	renal	ADJ
artofmedicineimsj-8	119	20	dysfunction	dysfunction	NOUN
artofmedicineimsj-8	119	21	in	in	ADP
artofmedicineimsj-8	119	22	ckd	ckd	PROPN
artofmedicineimsj-8	119	23	,	,	PUNCT
artofmedicineimsj-8	119	24	but	but	CCONJ
artofmedicineimsj-8	119	25	also	also	ADV
artofmedicineimsj-8	119	26	to	to	PART
artofmedicineimsj-8	119	27	improve	improve	VERB
artofmedicineimsj-8	119	28	the	the	DET
artofmedicineimsj-8	119	29	dyslipidemic	dyslipidemic	ADJ
artofmedicineimsj-8	119	30	process	process	NOUN
artofmedicineimsj-8	119	31	in	in	ADP
artofmedicineimsj-8	119	32	the	the	DET
artofmedicineimsj-8	119	33	body	body	NOUN
artofmedicineimsj-8	119	34	,	,	PUNCT
artofmedicineimsj-8	119	35	thereby	thereby	ADV
artofmedicineimsj-8	119	36	improving	improve	VERB
artofmedicineimsj-8	119	37	the	the	DET
artofmedicineimsj-8	119	38	functional	functional	ADJ
artofmedicineimsj-8	119	39	state	state	NOUN
artofmedicineimsj-8	119	40	of	of	ADP
artofmedicineimsj-8	119	41	the	the	DET
artofmedicineimsj-8	119	42	kidneys	kidney	NOUN
artofmedicineimsj-8	119	43	in	in	ADP
artofmedicineimsj-8	119	44	this	this	DET
artofmedicineimsj-8	119	45	category	category	NOUN
artofmedicineimsj-8	119	46	of	of	ADP
artofmedicineimsj-8	119	47	patients	patient	NOUN
artofmedicineimsj-8	119	48	.	.	PUNCT
artofmedicineimsj-8	120	1	references	reference	NOUN
artofmedicineimsj-8	120	2	:	:	PUNCT
artofmedicineimsj-8	120	3	1.bikbov	1.bikbov	NUM
artofmedicineimsj-8	120	4	b.t	b.t	PROPN
artofmedicineimsj-8	120	5	.	.	PROPN
artofmedicineimsj-8	120	6	,	,	PUNCT
artofmedicineimsj-8	120	7	tomilina	tomilina	PROPN
artofmedicineimsj-8	121	1	n.a	n.a	PROPN
artofmedicineimsj-8	121	2	.	.	PUNCT
artofmedicineimsj-8	122	1	the	the	DET
artofmedicineimsj-8	122	2	state	state	NOUN
artofmedicineimsj-8	122	3	of	of	ADP
artofmedicineimsj-8	122	4	substitution	substitution	NOUN
artofmedicineimsj-8	122	5	therapy	therapy	NOUN
artofmedicineimsj-8	122	6	in	in	ADP
artofmedicineimsj-8	122	7	patients	patient	NOUN
artofmedicineimsj-8	122	8	with	with	ADP
artofmedicineimsj-8	122	9	chronic	chronic	ADJ
artofmedicineimsj-8	122	10	renal	renal	ADJ
artofmedicineimsj-8	122	11	failure	failure	NOUN
artofmedicineimsj-8	122	12	in	in	ADP
artofmedicineimsj-8	122	13	the	the	DET
artofmedicineimsj-8	122	14	russian	russian	PROPN
artofmedicineimsj-8	122	15	federation	federation	PROPN
artofmedicineimsj-8	122	16	in	in	ADP
artofmedicineimsj-8	122	17	1998	1998	NUM
artofmedicineimsj-8	122	18	-	-	SYM
artofmedicineimsj-8	122	19	2007	2007	NUM
artofmedicineimsj-8	122	20	.	.	PUNCT
artofmedicineimsj-8	123	1	(	(	PUNCT
artofmedicineimsj-8	123	2	analytical	analytical	ADJ
artofmedicineimsj-8	123	3	report	report	NOUN
artofmedicineimsj-8	123	4	on	on	ADP
artofmedicineimsj-8	123	5	the	the	DET
artofmedicineimsj-8	123	6	data	datum	NOUN
artofmedicineimsj-8	123	7	of	of	ADP
artofmedicineimsj-8	123	8	the	the	DET
artofmedicineimsj-8	123	9	russian	russian	ADJ
artofmedicineimsj-8	123	10	register	register	NOUN
artofmedicineimsj-8	123	11	of	of	ADP
artofmedicineimsj-8	123	12	renal	renal	ADJ
artofmedicineimsj-8	123	13	replacement	replacement	NOUN
artofmedicineimsj-8	123	14	therapy	therapy	NOUN
artofmedicineimsj-8	123	15	)	)	PUNCT
artofmedicineimsj-8	123	16	//	//	SYM
artofmedicineimsj-8	123	17	nephrology	nephrology	NOUN
artofmedicineimsj-8	123	18	and	and	CCONJ
artofmedicineimsj-8	123	19	dialysis	dialysis	NOUN
artofmedicineimsj-8	123	20	.	.	PUNCT
artofmedicineimsj-8	124	1	2009	2009	NUM
artofmedicineimsj-8	124	2	.	.	PUNCT
artofmedicineimsj-8	125	1	no	no	INTJ
artofmedicineimsj-8	125	2	.	.	NOUN
artofmedicineimsj-8	126	1	3	3	X
artofmedicineimsj-8	126	2	.	.	X
artofmedicineimsj-8	126	3	ð	ð	X
artofmedicineimsj-8	126	4	.	.	PUNCT
artofmedicineimsj-8	127	1	144	144	NUM
artofmedicineimsj-8	127	2	-	-	SYM
artofmedicineimsj-8	127	3	233	233	NUM
artofmedicineimsj-8	127	4	.	.	PUNCT
artofmedicineimsj-8	128	1	2.bikbov	2.bikbov	NUM
artofmedicineimsj-8	128	2	b.t	b.t	PROPN
artofmedicineimsj-8	128	3	.	.	PROPN
artofmedicineimsj-8	128	4	,	,	PUNCT
artofmedicineimsj-8	128	5	tomilina	tomilina	PROPN
artofmedicineimsj-8	128	6	n.a	n.a	PROPN
artofmedicineimsj-8	128	7	.	.	PROPN
artofmedicineimsj-8	128	8	replacement	replacement	NOUN
artofmedicineimsj-8	128	9	therapy	therapy	NOUN
artofmedicineimsj-8	128	10	for	for	ADP
artofmedicineimsj-8	128	11	patients	patient	NOUN
artofmedicineimsj-8	128	12	with	with	ADP
artofmedicineimsj-8	128	13	chronic	chronic	ADJ
artofmedicineimsj-8	128	14	renal	renal	ADJ
artofmedicineimsj-8	128	15	failure	failure	NOUN
artofmedicineimsj-8	128	16	in	in	ADP
artofmedicineimsj-8	128	17	the	the	DET
artofmedicineimsj-8	128	18	russian	russian	PROPN
artofmedicineimsj-8	128	19	federation	federation	PROPN
artofmedicineimsj-8	128	20	in	in	ADP
artofmedicineimsj-8	128	21	1998	1998	NUM
artofmedicineimsj-8	128	22	-	-	SYM
artofmedicineimsj-8	128	23	2011	2011	NUM
artofmedicineimsj-8	128	24	.	.	PUNCT
artofmedicineimsj-8	129	1	//	//	SYM
artofmedicineimsj-8	129	2	nephrology	nephrology	NOUN
artofmedicineimsj-8	129	3	and	and	CCONJ
artofmedicineimsj-8	129	4	dialysis	dialysis	NOUN
artofmedicineimsj-8	129	5	.	.	PUNCT
artofmedicineimsj-8	130	1	2014.16	2014.16	NUM
artofmedicineimsj-8	130	2	(	(	PUNCT
artofmedicineimsj-8	130	3	1	1	NUM
artofmedicineimsj-8	130	4	)	)	PUNCT
artofmedicineimsj-8	130	5	.	.	PUNCT
artofmedicineimsj-8	131	1	p.	p.	NOUN
artofmedicineimsj-8	131	2	11	11	NUM
artofmedicineimsj-8	131	3	-	-	SYM
artofmedicineimsj-8	131	4	117	117	NUM
artofmedicineimsj-8	131	5	.	.	PUNCT
artofmedicineimsj-8	132	1	3.vyalkova	3.vyalkova	NUM
artofmedicineimsj-8	132	2	a.a	a.a	PROPN
artofmedicineimsj-8	132	3	.	.	PROPN
artofmedicineimsj-8	132	4	chronic	chronic	PROPN
artofmedicineimsj-8	132	5	kidney	kidney	PROPN
artofmedicineimsj-8	132	6	disease	disease	PROPN
artofmedicineimsj-8	132	7	//	//	SYM
artofmedicineimsj-8	132	8	orenburg	orenburg	PROPN
artofmedicineimsj-8	132	9	medical	medical	ADJ
artofmedicineimsj-8	132	10	bulletin	bulletin	NOUN
artofmedicineimsj-8	132	11	.	.	PUNCT
artofmedicineimsj-8	133	1	2015	2015	NUM
artofmedicineimsj-8	133	2	.	.	PUNCT
artofmedicineimsj-8	134	1	t.	t.	NOUN
artofmedicineimsj-8	134	2	3	3	X
artofmedicineimsj-8	134	3	.	.	PUNCT
artofmedicineimsj-8	135	1	no	no	INTJ
artofmedicineimsj-8	135	2	.	.	NOUN
artofmedicineimsj-8	135	3	2	2	NUM
artofmedicineimsj-8	135	4	(	(	PUNCT
artofmedicineimsj-8	135	5	10	10	NUM
artofmedicineimsj-8	135	6	)	)	PUNCT
artofmedicineimsj-8	135	7	.	.	PUNCT
artofmedicineimsj-8	136	1	p.	p.	NOUN
artofmedicineimsj-8	136	2	42	42	NUM
artofmedicineimsj-8	137	1	-	-	SYM
artofmedicineimsj-8	137	2	51	51	NUM
artofmedicineimsj-8	137	3	.	.	PUNCT
artofmedicineimsj-8	138	1	4.kuzmin	4.kuzmin	NUM
artofmedicineimsj-8	138	2	ob	ob	NOUN
artofmedicineimsj-8	138	3	et	et	PROPN
artofmedicineimsj-8	138	4	al	al	PROPN
artofmedicineimsj-8	138	5	.	.	PROPN
artofmedicineimsj-8	138	6	double	double	ADJ
artofmedicineimsj-8	138	7	blockade	blockade	NOUN
artofmedicineimsj-8	138	8	of	of	ADP
artofmedicineimsj-8	138	9	neprilysin	neprilysin	NOUN
artofmedicineimsj-8	138	10	and	and	CCONJ
artofmedicineimsj-8	138	11	at1	at1	PROPN
artofmedicineimsj-8	138	12	-	-	PUNCT
artofmedicineimsj-8	138	13	angiotensin	angiotensin	NOUN
artofmedicineimsj-8	138	14	receptors	receptor	NOUN
artofmedicineimsj-8	138	15	:	:	PUNCT
artofmedicineimsj-8	138	16	a	a	DET
artofmedicineimsj-8	138	17	new	new	ADJ
artofmedicineimsj-8	138	18	approach	approach	NOUN
artofmedicineimsj-8	138	19	to	to	ADP
artofmedicineimsj-8	138	20	antihypertensive	antihypertensive	ADJ
artofmedicineimsj-8	138	21	and	and	CCONJ
artofmedicineimsj-8	138	22	nephroprotective	nephroprotective	ADJ
artofmedicineimsj-8	138	23	therapy	therapy	NOUN
artofmedicineimsj-8	138	24	in	in	ADP
artofmedicineimsj-8	138	25	patients	patient	NOUN
artofmedicineimsj-8	138	26	with	with	ADP
artofmedicineimsj-8	138	27	arterial	arterial	ADJ
artofmedicineimsj-8	138	28	hypertension	hypertension	NOUN
artofmedicineimsj-8	138	29	//	//	SYM
artofmedicineimsj-8	138	30	arterial	arterial	NOUN
artofmedicineimsj-8	138	31	hypertension	hypertension	NOUN
artofmedicineimsj-8	138	32	.	.	PUNCT
artofmedicineimsj-8	139	1	2017	2017	NUM
artofmedicineimsj-8	139	2	.	.	PUNCT
artofmedicineimsj-8	140	1	t.	t.	NOUN
artofmedicineimsj-8	140	2	23	23	NUM
artofmedicineimsj-8	140	3	.	.	PUNCT
artofmedicineimsj-8	141	1	no	no	INTJ
artofmedicineimsj-8	141	2	.	.	NOUN
artofmedicineimsj-8	142	1	6	6	NUM
artofmedicineimsj-8	142	2	.	.	PUNCT
artofmedicineimsj-8	143	1	p.	p.	NOUN
artofmedicineimsj-8	143	2	498	498	NUM
artofmedicineimsj-8	143	3	-	-	SYM
artofmedicineimsj-8	143	4	506	506	NUM
artofmedicineimsj-8	143	5	.	.	PUNCT
artofmedicineimsj-8	144	1	5.national	5.national	NUM
artofmedicineimsj-8	144	2	recommendations	recommendation	NOUN
artofmedicineimsj-8	144	3	.	.	PUNCT
artofmedicineimsj-8	145	1	chronic	chronic	ADJ
artofmedicineimsj-8	145	2	kidney	kidney	NOUN
artofmedicineimsj-8	145	3	disease	disease	NOUN
artofmedicineimsj-8	145	4	:	:	PUNCT
artofmedicineimsj-8	145	5	basic	basic	ADJ
artofmedicineimsj-8	145	6	principles	principle	NOUN
artofmedicineimsj-8	145	7	of	of	ADP
artofmedicineimsj-8	145	8	screening	screening	NOUN
artofmedicineimsj-8	145	9	,	,	PUNCT
artofmedicineimsj-8	145	10	diagnosis	diagnosis	NOUN
artofmedicineimsj-8	145	11	,	,	PUNCT
artofmedicineimsj-8	145	12	prevention	prevention	NOUN
artofmedicineimsj-8	145	13	and	and	CCONJ
artofmedicineimsj-8	145	14	treatment	treatment	NOUN
artofmedicineimsj-8	145	15	approaches	approach	NOUN
artofmedicineimsj-8	145	16	//	//	PROPN
artofmedicineimsj-8	145	17	st	st	PROPN
artofmedicineimsj-8	145	18	.	.	PROPN
artofmedicineimsj-8	145	19	petersburg	petersburg	PROPN
artofmedicineimsj-8	145	20	:	:	PUNCT
artofmedicineimsj-8	145	21	publishing	publish	VERB
artofmedicineimsj-8	145	22	house	house	NOUN
artofmedicineimsj-8	145	23	"	"	PUNCT
artofmedicineimsj-8	145	24	levsha	levsha	PROPN
artofmedicineimsj-8	145	25	"	"	PUNCT
artofmedicineimsj-8	145	26	.	.	PUNCT
artofmedicineimsj-8	145	27	2012	2012	NUM
artofmedicineimsj-8	145	28	.	.	PUNCT
artofmedicineimsj-8	146	1	6.shestakova	6.shestakova	NUM
artofmedicineimsj-8	146	2	m.v	m.v	PROPN
artofmedicineimsj-8	146	3	.	.	PROPN
artofmedicineimsj-8	146	4	,	,	PUNCT
artofmedicineimsj-8	146	5	neverov	neverov	PROPN
artofmedicineimsj-8	146	6	i.i	i.i	PROPN
artofmedicineimsj-8	146	7	.	.	PROPN
artofmedicineimsj-8	146	8	,	,	PUNCT
artofmedicineimsj-8	146	9	dedov	dedov	PROPN
artofmedicineimsj-8	146	10	i.i	i.i	PROPN
artofmedicineimsj-8	146	11	.	.	PUNCT
artofmedicineimsj-8	147	1	the	the	DET
artofmedicineimsj-8	147	2	role	role	NOUN
artofmedicineimsj-8	147	3	of	of	ADP
artofmedicineimsj-8	147	4	intraglomerular	intraglomerular	ADJ
artofmedicineimsj-8	147	5	hypertension	hypertension	NOUN
artofmedicineimsj-8	147	6	and	and	CCONJ
artofmedicineimsj-8	147	7	lipids	lipid	NOUN
artofmedicineimsj-8	147	8	in	in	ADP
artofmedicineimsj-8	147	9	the	the	DET
artofmedicineimsj-8	147	10	development	development	NOUN
artofmedicineimsj-8	147	11	of	of	ADP
artofmedicineimsj-8	147	12	diabetic	diabetic	ADJ
artofmedicineimsj-8	147	13	nephropathy	nephropathy	NOUN
artofmedicineimsj-8	147	14	//	//	SYM
artofmedicineimsj-8	147	15	therapeutic	therapeutic	ADJ
artofmedicineimsj-8	147	16	archive	archive	NOUN
artofmedicineimsj-8	147	17	.	.	PUNCT
artofmedicineimsj-8	147	18	1993	1993	NUM
artofmedicineimsj-8	147	19	.	.	PUNCT
artofmedicineimsj-8	148	1	no	no	INTJ
artofmedicineimsj-8	148	2	.	.	NOUN
artofmedicineimsj-8	149	1	6	6	NUM
artofmedicineimsj-8	149	2	.	.	PUNCT
artofmedicineimsj-8	150	1	p.	p.	NOUN
artofmedicineimsj-8	150	2	61	61	NUM
artofmedicineimsj-8	150	3	-	-	SYM
artofmedicineimsj-8	150	4	65	65	NUM
artofmedicineimsj-8	150	5	.	.	PUNCT
artofmedicineimsj-8	151	1	7.shestakova	7.shestakova	NUM
artofmedicineimsj-8	151	2	m.v	m.v	PROPN
artofmedicineimsj-8	151	3	.	.	PROPN
artofmedicineimsj-8	151	4	,	,	PUNCT
artofmedicineimsj-8	151	5	dedov	dedov	PROPN
artofmedicineimsj-8	151	6	i.i	i.i	PROPN
artofmedicineimsj-8	151	7	.	.	PROPN
artofmedicineimsj-8	151	8	diabetes	diabetes	PROPN
artofmedicineimsj-8	151	9	mellitus	mellitus	NOUN
artofmedicineimsj-8	151	10	and	and	CCONJ
artofmedicineimsj-8	151	11	chronic	chronic	ADJ
artofmedicineimsj-8	151	12	kidney	kidney	NOUN
artofmedicineimsj-8	151	13	disease	disease	NOUN
artofmedicineimsj-8	151	14	//	//	PUNCT
artofmedicineimsj-8	151	15	m.	m.	NOUN
artofmedicineimsj-8	151	16	:	:	PUNCT
artofmedicineimsj-8	151	17	medical	medical	ADJ
artofmedicineimsj-8	151	18	information	information	NOUN
artofmedicineimsj-8	151	19	agency	agency	NOUN
artofmedicineimsj-8	151	20	.	.	PUNCT
artofmedicineimsj-8	152	1	2009	2009	NUM
artofmedicineimsj-8	152	2	.-p	.-p	PROPN
artofmedicineimsj-8	152	3	.	.	PUNCT
artofmedicineimsj-8	153	1	482	482	NUM
artofmedicineimsj-8	153	2	.	.	PUNCT
artofmedicineimsj-8	154	1	8.cepoi	8.cepoi	NUM
artofmedicineimsj-8	154	2	v.	v.	ADP
artofmedicineimsj-8	154	3	,	,	PUNCT
artofmedicineimsj-8	154	4	onofriescu	onofriescu	ADJ
artofmedicineimsj-8	154	5	m.	m.	NOUN
artofmedicineimsj-8	154	6	,	,	PUNCT
artofmedicineimsj-8	154	7	segall	segall	PROPN
artofmedicineimsj-8	154	8	l.	l.	PROPN
artofmedicineimsj-8	154	9	,	,	PUNCT
artofmedicineimsj-8	154	10	covic	covic	ADJ
artofmedicineimsj-8	154	11	a.	a.	NOUN
artofmedicineimsj-8	154	12	the	the	DET
artofmedicineimsj-8	154	13	prevalence	prevalence	NOUN
artofmedicineimsj-8	154	14	of	of	ADP
artofmedicineimsj-8	154	15	chronic	chronic	ADJ
artofmedicineimsj-8	154	16	kidney	kidney	NOUN
artofmedicineimsj-8	154	17	disease	disease	NOUN
artofmedicineimsj-8	154	18	in	in	ADP
artofmedicineimsj-8	154	19	the	the	DET
artofmedicineimsj-8	154	20	general	general	ADJ
artofmedicineimsj-8	154	21	population	population	NOUN
artofmedicineimsj-8	154	22	in	in	ADP
artofmedicineimsj-8	154	23	romania	romania	PROPN
artofmedicineimsj-8	154	24	:	:	PUNCT
artofmedicineimsj-8	154	25	a	a	DET
artofmedicineimsj-8	154	26	study	study	NOUN
artofmedicineimsj-8	154	27	on	on	ADP
artofmedicineimsj-8	154	28	60,000	60,000	NUM
artofmedicineimsj-8	154	29	persons	person	NOUN
artofmedicineimsj-8	154	30	//	//	X
artofmedicineimsj-8	154	31	int	int	NOUN
artofmedicineimsj-8	154	32	.	.	PUNCT
artofmedicineimsj-8	155	1	urol	urol	PROPN
artofmedicineimsj-8	155	2	.	.	PUNCT
artofmedicineimsj-8	156	1	nephrol	nephrol	PROPN
artofmedicineimsj-8	156	2	.	.	PUNCT
artofmedicineimsj-8	157	1	2012	2012	NUM
artofmedicineimsj-8	157	2	.	.	PUNCT
artofmedicineimsj-8	158	1	v.	v.	ADP
artofmedicineimsj-8	158	2	44	44	NUM
artofmedicineimsj-8	158	3	.	.	PUNCT
artofmedicineimsj-8	159	1	p.	p.	NOUN
artofmedicineimsj-8	159	2	213	213	NUM
artofmedicineimsj-8	159	3	.	.	PUNCT
artofmedicineimsj-8	160	1	9.cockcroft	9.cockcroft	NUM
artofmedicineimsj-8	160	2	d.w	d.w	PROPN
artofmedicineimsj-8	160	3	.	.	PROPN
artofmedicineimsj-8	160	4	,	,	PUNCT
artofmedicineimsj-8	160	5	gault	gault	PROPN
artofmedicineimsj-8	160	6	m.n	m.n	PROPN
artofmedicineimsj-8	160	7	.	.	PROPN
artofmedicineimsj-8	160	8	prediction	prediction	NOUN
artofmedicineimsj-8	160	9	of	of	ADP
artofmedicineimsj-8	160	10	clearance	clearance	NOUN
artofmedicineimsj-8	160	11	creatinine	creatinine	NOUN
artofmedicineimsj-8	160	12	from	from	ADP
artofmedicineimsj-8	160	13	serum	serum	PROPN
artofmedicineimsj-8	160	14	creatinine	creatinine	PROPN
artofmedicineimsj-8	160	15	//	//	X
artofmedicineimsj-8	160	16	nephron	nephron	PROPN
artofmedicineimsj-8	160	17	.	.	PUNCT
artofmedicineimsj-8	161	1	1976	1976	NUM
artofmedicineimsj-8	161	2	.	.	PUNCT
artofmedicineimsj-8	162	1	¹16	¹16	NUM
artofmedicineimsj-8	162	2	.	.	PUNCT
artofmedicineimsj-8	163	1	p.	p.	NOUN
artofmedicineimsj-8	163	2	31	31	NUM
artofmedicineimsj-8	163	3	-	-	SYM
artofmedicineimsj-8	163	4	41	41	NUM
artofmedicineimsj-8	163	5	.	.	PUNCT
artofmedicineimsj-8	164	1	10.collins	10.collins	NUM
artofmedicineimsj-8	164	2	a.j	a.j	PROPN
artofmedicineimsj-8	164	3	.	.	PROPN
artofmedicineimsj-8	164	4	,	,	PUNCT
artofmedicineimsj-8	164	5	foley	foley	PROPN
artofmedicineimsj-8	164	6	r.n	r.n	PROPN
artofmedicineimsj-8	164	7	.	.	PROPN
artofmedicineimsj-8	164	8	,	,	PUNCT
artofmedicineimsj-8	164	9	herzog	herzog	PROPN
artofmedicineimsj-8	164	10	c.	c.	PROPN
artofmedicineimsj-8	164	11	et	et	PROPN
artofmedicineimsj-8	164	12	al	al	PROPN
artofmedicineimsj-8	164	13	.	.	PROPN
artofmedicineimsj-8	164	14	united	united	PROPN
artofmedicineimsj-8	164	15	states	states	PROPN
artofmedicineimsj-8	164	16	renal	renal	ADJ
artofmedicineimsj-8	164	17	data	datum	NOUN
artofmedicineimsj-8	164	18	system	system	NOUN
artofmedicineimsj-8	164	19	2008	2008	NUM
artofmedicineimsj-8	164	20	.	.	PUNCT
artofmedicineimsj-8	165	1	annual	annual	ADJ
artofmedicineimsj-8	165	2	data	datum	NOUN
artofmedicineimsj-8	165	3	report	report	PROPN
artofmedicineimsj-8	165	4	//	//	SYM
artofmedicineimsj-8	165	5	american	american	PROPN
artofmedicineimsj-8	165	6	journal	journal	PROPN
artofmedicineimsj-8	165	7	of	of	ADP
artofmedicineimsj-8	165	8	kidney	kidney	NOUN
artofmedicineimsj-8	165	9	disease	disease	NOUN
artofmedicineimsj-8	165	10	.	.	PUNCT
artofmedicineimsj-8	166	1	2009	2009	NUM
artofmedicineimsj-8	166	2	.	.	PUNCT
artofmedicineimsj-8	167	1	¹53	¹53	PROPN
artofmedicineimsj-8	167	2	.	.	PUNCT
artofmedicineimsj-8	168	1	p.	p.	NOUN
artofmedicineimsj-8	168	2	1	1	NUM
artofmedicineimsj-8	168	3	-	-	SYM
artofmedicineimsj-8	168	4	374	374	NUM
artofmedicineimsj-8	168	5	.	.	PUNCT
artofmedicineimsj-8	169	1	(	(	PUNCT
artofmedicineimsj-8	169	2	12	12	NUM
artofmedicineimsj-8	169	3	)	)	PUNCT
artofmedicineimsj-8	169	4	11.crews	11.crews	NUM
artofmedicineimsj-8	169	5	d.c	d.c	PROPN
artofmedicineimsj-8	169	6	.	.	PROPN
artofmedicineimsj-8	169	7	,	,	PUNCT
artofmedicineimsj-8	169	8	plantinga	plantinga	PROPN
artofmedicineimsj-8	169	9	l.c	l.c	PROPN
artofmedicineimsj-8	169	10	.	.	PROPN
artofmedicineimsj-8	169	11	,	,	PUNCT
artofmedicineimsj-8	169	12	miller	miller	PROPN
artofmedicineimsj-8	169	13	e.r	e.r	PROPN
artofmedicineimsj-8	169	14	.	.	PROPN
artofmedicineimsj-8	169	15	et	et	PROPN
artofmedicineimsj-8	169	16	al	al	PROPN
artofmedicineimsj-8	169	17	.	.	PUNCT
artofmedicineimsj-8	170	1	prevalence	prevalence	NOUN
artofmedicineimsj-8	170	2	of	of	ADP
artofmedicineimsj-8	170	3	chronic	chronic	ADJ
artofmedicineimsj-8	170	4	kidney	kidney	NOUN
artofmedicineimsj-8	170	5	disease	disease	NOUN
artofmedicineimsj-8	170	6	in	in	ADP
artofmedicineimsj-8	170	7	persons	person	NOUN
artofmedicineimsj-8	170	8	with	with	ADP
artofmedicineimsj-8	170	9	undiagnosed	undiagnosed	ADJ
artofmedicineimsj-8	170	10	or	or	CCONJ
artofmedicineimsj-8	170	11	prehypertension	prehypertension	NOUN
artofmedicineimsj-8	170	12	in	in	ADP
artofmedicineimsj-8	170	13	the	the	DET
artofmedicineimsj-8	170	14	united	united	PROPN
artofmedicineimsj-8	170	15	states	states	PROPN
artofmedicineimsj-8	170	16	//	//	PROPN
artofmedicineimsj-8	170	17	hypertension	hypertension	NOUN
artofmedicineimsj-8	170	18	.	.	PUNCT
artofmedicineimsj-8	171	1	2010	2010	NUM
artofmedicineimsj-8	171	2	.	.	PUNCT
artofmedicineimsj-8	172	1	v.	v.	ADP
artofmedicineimsj-8	172	2	55	55	NUM
artofmedicineimsj-8	172	3	.	.	PUNCT
artofmedicineimsj-8	173	1	p.	p.	NOUN
artofmedicineimsj-8	173	2	1102	1102	NUM
artofmedicineimsj-8	174	1	12.duru	12.duru	X
artofmedicineimsj-8	174	2	o.k	o.k	PROPN
artofmedicineimsj-8	174	3	.	.	PROPN
artofmedicineimsj-8	174	4	,	,	PUNCT
artofmedicineimsj-8	174	5	vargas	vargas	PROPN
artofmedicineimsj-8	174	6	r.b	r.b	PROPN
artofmedicineimsj-8	174	7	.	.	PROPN
artofmedicineimsj-8	174	8	,	,	PUNCT
artofmedicineimsj-8	174	9	kermah	kermah	PROPN
artofmedicineimsj-8	175	1	d.	d.	PROPN
artofmedicineimsj-8	175	2	et	et	PROPN
artofmedicineimsj-8	175	3	al	al	PROPN
artofmedicineimsj-8	175	4	.	.	PROPN
artofmedicineimsj-8	176	1	high	high	ADJ
artofmedicineimsj-8	176	2	prevalence	prevalence	NOUN
artofmedicineimsj-8	176	3	of	of	ADP
artofmedicineimsj-8	176	4	stage	stage	NOUN
artofmedicineimsj-8	176	5	3	3	NUM
artofmedicineimsj-8	176	6	chronic	chronic	ADJ
artofmedicineimsj-8	176	7	kidney	kidney	NOUN
artofmedicineimsj-8	176	8	disease	disease	NOUN
artofmedicineimsj-8	176	9	in	in	ADP
artofmedicineimsj-8	176	10	older	old	ADJ
artofmedicineimsj-8	176	11	adults	adult	NOUN
artofmedicineimsj-8	176	12	despite	despite	SCONJ
artofmedicineimsj-8	176	13	normal	normal	ADJ
artofmedicineimsj-8	176	14	serum	serum	NOUN
artofmedicineimsj-8	176	15	creatinine	creatinine	PROPN
artofmedicineimsj-8	176	16	//	//	PROPN
artofmedicineimsj-8	176	17	journal	journal	PROPN
artofmedicineimsj-8	176	18	of	of	ADP
artofmedicineimsj-8	176	19	internal	internal	ADJ
artofmedicineimsj-8	176	20	medicine	medicine	NOUN
artofmedicineimsj-8	176	21	.	.	PUNCT
artofmedicineimsj-8	177	1	2009	2009	NUM
artofmedicineimsj-8	177	2	.	.	PUNCT
artofmedicineimsj-8	178	1	v.	v.	ADP
artofmedicineimsj-8	178	2	24	24	NUM
artofmedicineimsj-8	178	3	.	.	PUNCT
artofmedicineimsj-8	179	1	p.	p.	NOUN
artofmedicineimsj-8	179	2	86	86	NUM
artofmedicineimsj-8	179	3	-	-	SYM
artofmedicineimsj-8	179	4	92	92	NUM
artofmedicineimsj-8	179	5	.	.	PUNCT
artofmedicineimsj-8	180	1	13.kdigo	13.kdigo	NUM
artofmedicineimsj-8	180	2	2012	2012	NUM
artofmedicineimsj-8	180	3	clinical	clinical	ADJ
artofmedicineimsj-8	180	4	practice	practice	NOUN
artofmedicineimsj-8	180	5	guideline	guideline	NOUN
artofmedicineimsj-8	180	6	for	for	ADP
artofmedicineimsj-8	180	7	the	the	DET
artofmedicineimsj-8	180	8	evaluation	evaluation	NOUN
artofmedicineimsj-8	180	9	and	and	CCONJ
artofmedicineimsj-8	180	10	management	management	NOUN
artofmedicineimsj-8	180	11	of	of	ADP
artofmedicineimsj-8	180	12	chronic	chronic	ADJ
artofmedicineimsj-8	180	13	kidney	kidney	NOUN
artofmedicineimsj-8	180	14	disease	disease	NOUN
artofmedicineimsj-8	180	15	//	//	SYM
artofmedicineimsj-8	180	16	kidney	kidney	PROPN
artofmedicineimsj-8	180	17	int	int	NOUN
artofmedicineimsj-8	180	18	.	.	PUNCT
artofmedicineimsj-8	181	1	suppl	suppl	PROPN
artofmedicineimsj-8	181	2	.	.	PUNCT
artofmedicineimsj-8	181	3	2013	2013	NUM
artofmedicineimsj-8	181	4	.	.	PUNCT
artofmedicineimsj-8	182	1	-v	-v	X
artofmedicineimsj-8	182	2	.	.	NOUN
artofmedicineimsj-8	183	1	3	3	X
artofmedicineimsj-8	183	2	.	.	X
artofmedicineimsj-8	183	3	p.1	p.1	NOUN
artofmedicineimsj-8	183	4	-	-	PUNCT
artofmedicineimsj-8	183	5	150	150	NUM
artofmedicineimsj-8	183	6	.	.	PUNCT
artofmedicineimsj-8	184	1	14.levey	14.levey	NUM
artofmedicineimsj-8	184	2	a.s	a.s	PROPN
artofmedicineimsj-8	184	3	.	.	PROPN
artofmedicineimsj-8	184	4	,	,	PUNCT
artofmedicineimsj-8	184	5	stevens	stevens	PROPN
artofmedicineimsj-8	184	6	l.a	l.a	PROPN
artofmedicineimsj-8	184	7	.	.	PROPN
artofmedicineimsj-8	184	8	,	,	PUNCT
artofmedicineimsj-8	184	9	schmid	schmid	PROPN
artofmedicineimsj-8	184	10	c.h	c.h	PROPN
artofmedicineimsj-8	184	11	.	.	PROPN
artofmedicineimsj-8	184	12	et	et	PROPN
artofmedicineimsj-8	184	13	al	al	PROPN
artofmedicineimsj-8	184	14	.	.	PUNCT
artofmedicineimsj-8	185	1	a	a	DET
artofmedicineimsj-8	185	2	new	new	ADJ
artofmedicineimsj-8	185	3	equation	equation	NOUN
artofmedicineimsj-8	185	4	to	to	PART
artofmedicineimsj-8	185	5	estimate	estimate	VERB
artofmedicineimsj-8	185	6	glomerular	glomerular	ADJ
artofmedicineimsj-8	185	7	filtration	filtration	NOUN
artofmedicineimsj-8	185	8	rate	rate	NOUN
artofmedicineimsj-8	185	9	//	//	PROPN
artofmedicineimsj-8	185	10	ann	ann	PROPN
artofmedicineimsj-8	185	11	.	.	PUNCT
artofmedicineimsj-8	186	1	internal	internal	ADJ
artofmedicineimsj-8	186	2	medicine	medicine	NOUN
artofmedicineimsj-8	186	3	.	.	PUNCT
artofmedicineimsj-8	187	1	2009	2009	NUM
artofmedicineimsj-8	187	2	.	.	PUNCT
artofmedicineimsj-8	188	1	v.150	v.150	NOUN
artofmedicineimsj-8	188	2	.	.	PUNCT
artofmedicineimsj-8	189	1	p.	p.	NOUN
artofmedicineimsj-8	189	2	604	604	NUM
artofmedicineimsj-8	189	3	-	-	SYM
artofmedicineimsj-8	189	4	12	12	NUM
artofmedicineimsj-8	189	5	.	.	PUNCT
artofmedicineimsj-8	190	1	15.national	15.national	NUM
artofmedicineimsj-8	190	2	kidney	kidney	NOUN
artofmedicineimsj-8	190	3	foundation	foundation	NOUN
artofmedicineimsj-8	190	4	.	.	PUNCT
artofmedicineimsj-8	191	1	k	k	X
artofmedicineimsj-8	191	2	/	/	SYM
artofmedicineimsj-8	191	3	doqi	doqi	PROPN
artofmedicineimsj-8	191	4	clinical	clinical	ADJ
artofmedicineimsj-8	191	5	practice	practice	NOUN
artofmedicineimsj-8	191	6	guidelines	guideline	NOUN
artofmedicineimsj-8	191	7	for	for	ADP
artofmedicineimsj-8	191	8	chronic	chronic	ADJ
artofmedicineimsj-8	191	9	kidney	kidney	NOUN
artofmedicineimsj-8	191	10	disease	disease	NOUN
artofmedicineimsj-8	191	11	:	:	PUNCT
artofmedicineimsj-8	191	12	evaluation	evaluation	NOUN
artofmedicineimsj-8	191	13	,	,	PUNCT
artofmedicineimsj-8	191	14	classification	classification	NOUN
artofmedicineimsj-8	191	15	and	and	CCONJ
artofmedicineimsj-8	191	16	stratification	stratification	PROPN
artofmedicineimsj-8	191	17	//	//	SYM
artofmedicineimsj-8	191	18	american	american	PROPN
artofmedicineimsj-8	191	19	journal	journal	PROPN
artofmedicineimsj-8	191	20	of	of	ADP
artofmedicineimsj-8	191	21	kidney	kidney	NOUN
artofmedicineimsj-8	191	22	disease	disease	NOUN
artofmedicineimsj-8	191	23	.	.	PUNCT
artofmedicineimsj-8	192	1	2002	2002	NUM
artofmedicineimsj-8	192	2	.	.	PUNCT
artofmedicineimsj-8	193	1	s.	s.	PROPN
artofmedicineimsj-8	193	2	39	39	NUM
artofmedicineimsj-8	193	3	.	.	PUNCT
artofmedicineimsj-8	194	1	p.	p.	NOUN
artofmedicineimsj-8	194	2	1	1	NUM
artofmedicineimsj-8	194	3	-	-	SYM
artofmedicineimsj-8	194	4	266	266	NUM
artofmedicineimsj-8	194	5	.	.	PUNCT
artofmedicineimsj-8	195	1	16.shahinian	16.shahinian	NUM
artofmedicineimsj-8	195	2	v.b	v.b	PROPN
artofmedicineimsj-8	195	3	.	.	PROPN
artofmedicineimsj-8	195	4	,	,	PUNCT
artofmedicineimsj-8	195	5	hedgeman	hedgeman	PROPN
artofmedicineimsj-8	195	6	e.	e.	PROPN
artofmedicineimsj-8	195	7	,	,	PUNCT
artofmedicineimsj-8	195	8	gillespie	gillespie	PROPN
artofmedicineimsj-8	195	9	b.w	b.w	PROPN
artofmedicineimsj-8	195	10	.	.	PROPN
artofmedicineimsj-8	195	11	cdc	cdc	PROPN
artofmedicineimsj-8	195	12	ckd	ckd	PROPN
artofmedicineimsj-8	195	13	surveillance	surveillance	NOUN
artofmedicineimsj-8	195	14	system	system	NOUN
artofmedicineimsj-8	195	15	.	.	PUNCT
artofmedicineimsj-8	196	1	estimating	estimate	VERB
artofmedicineimsj-8	196	2	prevalence	prevalence	NOUN
artofmedicineimsj-8	196	3	of	of	ADP
artofmedicineimsj-8	196	4	ckd	ckd	PROPN
artofmedicineimsj-8	196	5	stages	stage	VERB
artofmedicineimsj-8	196	6	3	3	NUM
artofmedicineimsj-8	196	7	-	-	SYM
artofmedicineimsj-8	196	8	5	5	NUM
artofmedicineimsj-8	196	9	using	use	VERB
artofmedicineimsj-8	196	10	health	health	NOUN
artofmedicineimsj-8	196	11	system	system	NOUN
artofmedicineimsj-8	196	12	data	datum	NOUN
artofmedicineimsj-8	196	13	.	.	PUNCT
artofmedicineimsj-8	197	1	american	american	PROPN
artofmedicineimsj-8	197	2	journal	journal	PROPN
artofmedicineimsj-8	197	3	of	of	ADP
artofmedicineimsj-8	197	4	kidney	kidney	NOUN
artofmedicineimsj-8	197	5	disease	disease	NOUN
artofmedicineimsj-8	197	6	.	.	PUNCT
artofmedicineimsj-8	198	1	2013	2013	NUM
artofmedicineimsj-8	198	2	.	.	PUNCT
artofmedicineimsj-8	199	1	v.	v.	ADP
artofmedicineimsj-8	199	2	61	61	NUM
artofmedicineimsj-8	199	3	.	.	PUNCT
artofmedicineimsj-8	200	1	p.	p.	NOUN
artofmedicineimsj-8	200	2	930	930	NUM
artofmedicineimsj-8	200	3	.	.	PUNCT