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Available online at ajdhs.com 

Asian Journal of Dental and Health Sciences 
Open Access to Dental and Medical Research 

Copyright  © 2025 The  Author(s): This is an open-access article distributed under the terms of the CC BY-NC 4.0 
which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the 

original author and source are credited  

 

 

Oral health benefits of Moringa oleifera  

Sunil Kumar Prajapati 1 , Omji Porwal 2 , Raghunandan Meena 3, Rajeshwar Kamal Kant Arya 4 , Ram C 
Dhakar 5* , Kapil Kumar 6  

1 Professor, Institute of Pharmacy, Bundelkhand University, Jhansi, India 

2 Professor, Department of Pharmacognosy, Faculty of Pharmacy, Tishk International University-Erbil, Kurdistan Region, Iraq 

3 Professor, Department of General Medicine, Jhalawar Medical College, Jhalawar, Rajasthan, India 

4 Associate Professor, Department of Pharmaceutical Sciences, Sir JC Bose Technical Campus, Bhimtal, Kumaun University, Nainital, India 

5 Hospital Pharmacist, SRG Hospital & Medical College, Jhalawar, Rajasthan, India 

6 Professor and Director, Samrat Prithviraj Chauhan College of Pharmacy, Kashipur, Uttarakhand Technical University, Uttarakhand, India. 

Article Info: 
_____________________________________________ 
Article History: 

Received   03 Sep 2025     
Reviewed  24 Oct 2025 
Accepted   19 Nov 2025 
Published 15 Dec 2025 

_____________________________________________ 
Cite this article as:  

Prajapati SK, Porwal O, Meena R, Arya RKK, 
Dhakar RC, Kumar K, Oral health benefits of 
Moringa oleifera, Asian Journal of Dental and 
Health Sciences. 2025; 5(4):7-12 

DOI: http://dx.doi.org/10.22270/ajdhs.v5i4.147               

Abstract 
_________________________________________________________________________________________________________________ 
Allopathic medicines are used to treat or manage dental infections, inflammation, and pain. But 
due to the adverse effects associated with these allopathic medicines, Herbal Medicine should be 
considered as an alternative therapy for the management of oral health and treating dental Pain. 
Oral diseases persist as a significant health problem all over the world. Various microorganisms 
have been identified as possible pathogens responsible for oral diseases. Moringa oleifera has 
been used in traditional medicine for centuries. All parts of the Moringa tree are helpful in some 
way, and people depend on it for their livelihood. The leaves of the Moringa tree are an excellent 
source of Nutrients like Minerals, Protein and Vitamins (A and C). The Moringa tree contains 
approximately 46 antioxidants and is one of the cheapest sources of natural antioxidants. 
Antioxidants provide the free radicals the human body needs and mitigate their effects. Moringa 
oleifera contains active compounds such as flavonoids, tannins, saponins, alkaloids, phenolics, and 
triterpenoids, which possess antibacterial effects. Moringa oleifera has high mineral and protein 
content and has been previously investigated for its potential in the treatment of various oral soft 
tissue diseases.  This review summaries the applications of Moringa oleifera in dentistry. 

Keywords: Moringa oleifera, Anti-oxidants, Oral diseases, Oral health, dentistry 

*Address for Correspondence:   

Ram Chand Dhakar, Hospital Pharmacist, SRG Hospital & Medical College, Jhalawar, Rajasthan, India 

 

Introduction 

Global Burden of Disease (2019) show that periodontal 
disease ranks as the seventh most prevalent disease 
globally, with a prevalence of 29.3%.1 According to the 
Riskesdas report (2018), the prevalence of periodontal 
disease in Indonesia is 74.1%. 2, 3 Dental health has been 
a concern for researchers to this day. Various infections 
that can occur in the teeth can lead to health decline. 
Dental infections occur due to the growth of different 
microbes in the oral cavity and dental area. Among 
these are odontogenic infections and periradicular 
periodontitis that happen in the root canal system, 
caused by anaerobic bacteria such as Porphyromonas 
gingivalis, Enterococcus faecalis, and Candida albicans 4, 

5, 6, 7. Natural products have been used as folk medicines 
for thousands of years and are promising sources for 
novel therapeutic agents. Due to the adverse effects 
associated with allopathic medication, herbal medicines 
are preferred as an alternative therapy for the 
management of oral health and dental Pain. 3,  8 , 9 

Moringa oleifera is the most widely cultivated pan-
tropical species of a monogeneric family, the 
Moringaceae, which is native to the sub-Himalayan 
tracts of India, Pakistan, Bangladesh and Afghanistan. 
Moringa oleifera. Moringa is known by various local 
names, such as benzolive, drumstick tree, kelor, 
marango, mlonge, mulangay, nébéday, saijhan, and 
sajna. 10, 11. All parts of the moringa are beneficial, as 
they contain a variety of phytoconstituents with 
nutritional and pharmacological value. In developing 
tropical countries, Moringa trees have been used to 
combat malnutrition, especially among infants and 
nursing mothers 11,12,13. Moringa leaves are an excellent 
source of Nutrients like Minerals, Protein and Vitamins 
(A and C) 14,15,16. Moringa is one of the most potent 
sources of natural antioxidants, containing 
approximately 46 antioxidants. Moringa contains 
antioxidants that the human body needs to mitigate the 
effects of free radicals. M. oleifera contains many 
phytochemicals such as flavonoids, tannins, saponins, 
alkaloids, phenolics, and triterpenoids, which possess 
antibacterial effects. This review summaries the 

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Prajapati et al.                                                                                                                               Asian Journal of Dental and Health Sciences. 2025; 5(4):7-12 

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applications of Moringa extracts in the management of 
oral infections, inflammatory conditions, the 
remineralisation of hard tissues, oral wound healing, 
and tissue regeneration. 

Oral health benefits of Moringa oleifera  

The Moringa tree is one of the most potent sources of 
natural antioxidants, with approximately 46 
antioxidants. M. oleifera contains active compounds 
such as flavonoids, tannins, saponins, alkaloids, 
phenolics, and triterpenoids, which possess anti-
bacterial effects. Many adverse effects are associated 
with allopathic medicines; hence, they can be used as a 
safe and cheap antimicrobial agent as an alternative 
therapy. The extract from leaves of Moringa oleifera has 
high mineral and protein content and its historic 
reputation as a traditional medicine for different 
diseases has been previously investigated for its 
potential in treating various oral soft tissue diseases 
17, 18.  

Moringa oleifera extract contains the highest values of 
calcium and phosphate that are required for the 
remineralization process. Therefore, Moringa oleifera 
extract is investigated by Younis et al for its ability to 
treat induced enamel lesions, and results suggest that 
the formulated varnish reinforced mineralisation of the 
lesions with complete reestablishment of the enamel 
surface in comparison to plain and fluoride varnishes. 17 
in a study by Yunus et al. Scanning electron microscopy 
revealed that the Moringa oleifera Leaves extract-loaded 
varnish showed the most re-establishment of normal 
enamel architecture. Elemental analysis of the treated 
surfaces showed the surfaces treated by Moringa 
oleifera leaf extract-loaded varnish groups had 
significantly higher Ca, P, and O deposition than the 
fluoride varnish group. Hence, Moringa oleifera 
Leaves extract might be considered as a biomimetic 
material as it has the capacity to guide enamel tissue 
remineralization.19 

Hanaa Elgamily et al. carried out a study to assess the 
antibacterial and antifungal potentials of different parts 
of the Moringa oleifera plant using various extraction 
methods, to formulate natural dental remedies from this 
plant. The various extracts of different parts of Moringa 
oleifera showed an antibacterial effect against 
Staphylococcus aureus and Streptococcus mutans 
growth. The novel toothpaste of ethanolic leaves extract 
has antimicrobial and antifungal potential effects all 
selected strains.20 The results of the study by Risnayanti 
Anas et al. revealed an increase in calcium levels in the 
teeth after application of a Moringa oleifera-based paste 
and Casein phosphopeptide-amorphous calcium 
phosphate (CPP-ACP). Moringa oleifera based paste and 
CPP-APP are effective to increasing calcium levels in 
teeth compared to the pre-test group.21 

Dental caries is closely related to cariogenic biofilm, an 
oral biofilm containing a high proportion of 
Streptococcus mutans 22. Generally, oral biofilm is 
structurally and functionally organized and includes a 
balance of normal flora and pathogenic bacteria like S. 
mutans 23. Su-Kyung Jwa has investigated the 
antimicrobial effects of the M. oleifera leaf extracts on S. 
mutans and the formation of cariogenic biofilm. An 
extract from M. oleifera leaves was derived using 
distilled water (DW) and ethyl alcohol (EtOH). S. 
mutans susceptibility assays were performed for each 
extract. Cariogenic biofilm was formed with or without 
DW and EtOH extract, and cariogenic biofilm was 
treated with both extracts. Both extracts showed 
antimicrobial activity against S. mutans and inhibited 
the formation of cariogenic biofilm. At the same 
concentration, the heated ethanol extract exhibited 
inhibitory activity better than the non-heated extracts.  
This study showed that the ethanol extract was more 
effective than the aqueous extract against S. mutans 24

 

Table 1: Application of Moringa oleifera in Oral health 

S.N. Author Objective of the study Application Ref 
1 Rao P K, et al 

2011 
To assess the antibacterial 
activity of isolated compounds 
from M. oleifera against selected 
oral bacteria 

All the isolated compounds from M. oleifera were 
active against Streptococcus mutans (MTCC 497), 
Streptococcus salivarius, Lactobacillus fermentum, 
Streptococcus anginosus, Streptococcus gordonii, 
Lactobacillus acidophilus. 

25 

2 Hanaa 
Elgamily et al 
2016 

To assess the antibacterial and 
antifungal potentials of different 
parts of Moringa oleifera  

For dental remedies, experimental toothpaste 
exhibited higher mean inhibition than the 
mouthwash against Staphylococcus aureus, 
Streptococcus mutans and only the toothpaste 
revealed antifungal effect against Candida albicans 

20 

4 Carranza J B, 
2017 

To identify the secondary 
compounds of three varieties of 
Moringa oleifera Lam. Extracts 
namely; Native, Chinese, and Yard 
Long malunggay using 
phytochemical analysis 

The extracts of moringa varieties contain flavonoids, 
alkaloids and tannins that are known to have 
antimicrobial and anti-inflammatory properties; thus, 
these have potential natural components in the 
manufacture of toothpastes 

26 

5 Su-Kyung Jwa 
et 2019 

to investigate the antimicrobial 
effects of the M. oleifera leaf 
extracts 

extracts showed antimicrobial activity against S. 
mutans and inhibited formation of cariogenic biofilm 

24 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522384/#bib6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522384/#bib7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779079/#b11-pnfs-24-308
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779079/#b13-pnfs-24-308
https://www.ncbi.nlm.nih.gov/pubmed/?term=Jwa%20SK%5bAuthor%5d&cauthor=true&cauthor_uid=31608256
https://www.ncbi.nlm.nih.gov/pubmed/?term=Jwa%20SK%5bAuthor%5d&cauthor=true&cauthor_uid=31608256
https://www.ncbi.nlm.nih.gov/pubmed/?term=Jwa%20SK%5bAuthor%5d&cauthor=true&cauthor_uid=31608256


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6 Piasti 
Sopandani et 
al 2020 

 to assess the antibacterial effect 
of M. oleifera extract as an 
irrigation solution against E. 
faecalis 

M. oleifera extract solution at concentrations of 75% 
and 100% is as effective as 5.25% NaOCl against E. 
faecalis 

27 

7 Mahassen M 
Farghaly et al 
2020 

to formulate a nontoxic 
mouthwash from Moringa 
oleifera 

Moringa extract showing antibacterial and antiplaque 
effect will be used 

28 

8 Younis SH 
2020 

To assess the effect of 
Leaves extract of Moringa oleifera 
loaded-varnish groups IV & V on 
enamel  

Moringa leaf extract loaded-varnish groups had 
significantly higher Ca, P, and O deposition than the 
fluoride varnish group. The extract of Moringa 
oleifera leaves might be considered as a biomimetic 
material that has the capacity to guide enamel tissue 
remineralization 

19 

9 Anas R et al 
2021 

To study the Effectiveness of 
paste-based Moringa oleifera To 
Increase Calcium Levels in 
Human Tooth 

Results of this research showed that Moringa Oleifera 
paste has a higher calcium level compared to the Pre-
test groups and Moringa oleifera paste can be 
effective in increasing calcium levels of human teeth  

21 

10 Nawal 
Aidaros et al 
2021 

To investigate and compare the 
effect of green tea, black tea and 
Moringa oleifera on artificially 
demineralized enamel and dentin 

In dentin, the highest mean value was found in 
Moringa oleifera. Study concluded that Moringa tree 
enhanced the remineralization process and thus, 
might be considered as an effective natural 
remineralizing agents 

29 

11 Buakaew et al 
2021 

Moringa oleifera and Azadirachta 
indica were assessed for oral 
healthcare and gingivitis 
adjunctive treatment 

The author states that accumulative reduction 
percentages of both Staphylococcus spp. and 
Candida spp. were found and indicated that the 
herbal mouthwashes reduced Gingival index and 
plaque index and showed potential as oral healthcare 
products 

30 

 

A study by Nawal Aidaros et al concluded that Moringa 
oleifera enhanced the remineralisation process of 
demineralised enamel and dentin, and thus, might be 
considered as an effective natural remineralising 
agent29. Few studies have evaluated the biological 
activity of M. oleifera in relation to oral disorders. M. 
oleifera leaves extracts in form of lozenge or mouthwash 
successfully reduced root canal infection, inflammation, 
gingivitis, and plaque 30, 31, 32. Isothiocyanate from M. 
oleifera seeds showed inhibitory action against gene 
expression involved in mitophagy in the stem cell of the 
human periodontal ligament 33,34 A hydrophilic gel of M. 
oleifera and acemannan extract was used to coat 
titanium dental implants before implanting them within 
the tibia and femur of rabbits. These coatings produced 
hydrophilic implant surfaces that improved bone-to-
implant contact, stimulated new bone formation, and 
reduced inflammation, fibrosis, and degenerative and 
necrotic changes within the newly formed bone 35. 

In recent investigations, the antimicrobial efficacy of M. 
oleifera leaf extract was examined by Alharbi et al. who 
compared the microbial efficacy of Moringa oleifera leaf 
extract, octenidine dihydrochloride (OCT), NaOCl, and 
their combinations as intracanal irrigants 
against Enterococcus faecalis.  Both M. oleifera extract 
and 0.1% OCT demonstrated antibacterial effects 
against E. faecalis comparable to 2.5% NaOCl and could 
be considered as potential root canal irrigants. 
Furthermore, combination groups exhibited superior 
anti-microbial activity compared to individual irrigants. 
However, further studies are required to investigate the 
biocompatibility and possible toxic effects of the tested 
irrigants.36. 

Sharma et al evaluated the efficacy of chitosan chips 
with and without Moringa oleifera (MO) in treating 
chronic periodontitis. Results from this study revealed 
that Moringa oleifera in chitosan chips may be an 
effective natural treatment for chronic periodontitis. 
The study shows significant improvements in clinical 
parameters, including plaque index, gingival index, and 
probing pocket depth, in the Moringa group, suggesting 
its potential to enhance treatment outcomes in 
periodontal care. Further exploration of its applications 
is encouraged. 37 Kumar et al. investigated the 
antimicrobial effects of M. oleifera extracts to assess the 
antibacterial efficacy of 5% Moringa oleifera mouthwash 
reinforced with silver nanoparticles against oral aerobic 
organisms. The results of the study revealed that the 5% 
aqueous extract of M. oleifera exhibited a dose-
dependent antimicrobial activity against oral anaerobic 
microorganisms. Notably, this anti-microbial effect 
became more pronounced with longer exposure times 
of the treated samples. Furthermore, in the cytotoxicity 
assay, the aqueous extract exhibited superior 
performance at lower concentrations than the ethanol 
extract. The combined benefits of phytomedicine with 
nanomedicine can result in more effective treatment 
with fewer side effects. 38.  

In the recent investigation, Eliwa et al. compared the 
remineralising potential of Moringa Oleifera extract, 
eggshell, and sodium fluoride varnish on the 
microhardness of artificially demineralised enamel of 
primary teeth using a biomimetic, minimally invasive 
approach, following the world paradigm shift towards 
natural products in paediatric dentistry. Regarding EDX 
analysis, there was a statistically significant difference 

https://www.scidentj.com/searchresult.asp?search=&author=Piasti+Sopandani&journal=Y&but_search=Search&entries=10&pg=1&s=0
https://www.scidentj.com/searchresult.asp?search=&author=Piasti+Sopandani&journal=Y&but_search=Search&entries=10&pg=1&s=0
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(p < 0.05) between the Moringa Oleifera and Eggshell 
groups compared with the fluoride varnish, with the 
highest values observed in the Moringa Oleifera and 
Eggshell groups. On the other hand, there was no 
statistically significant difference (p > 0.05) between 
Moringa Oleifera and Eggshell in both measurements. 
Moringa Oleifera and Eggshell might be considered 
biomimetic natural materials capable of guiding enamel 
tissue remineralisation in early carious lesions of 
primary teeth. 39 Soraya et al. investigated the anti-
bacterial properties of M. oleifera gel in inhibiting the 
growth of S. mutans, which were involved in the 
pathogenesis of dental caries. After 48 h, the 12.5% 
concentration exhibited the highest effectiveness in 
reducing S. mutans growth. Within 24 h, the 6.25% and 
3.125% concentrations exhibited remarkable ability to 
suppress S. mutans growth. Notably, the 6.25% 
concentration exhibited superior efficacy in reducing S. 
mutans biofilm formation. The application of M. 
oleifera gel extract created conditions in which S. 
mutans, a commensal bacterium, struggled to form a 
biofilm, with inhibition levels surpassing 70%. The 
absence of substantial biofilm development evidenced 
this. It is worth mentioning that at all tested 
concentrations, M. oleifera exhibited a toxic effect on S. 
mutans cells. The ethanol extract gel of M. 
oleifera demonstrated the ability to curtail both the 
growth and biofilm formation of S. mutans on tooth 
surfaces while concurrently exerting toxicity on S. 
mutans cells, potentially due to the presence of anti-
bacterial compounds 40. Amalunweze et al formulated 
antimicrobial toothpaste (dentifrice) with M. 
oleifera root essential oil, which can compete with 
existing toothpaste. The phytochemical screening 
revealed a high concentration of flavonoid, a bioactive 
agent with antimicrobial activity in nature. The 
antimicrobial potential of this toothpaste was evaluated 
by the muller Hinton agar well diffusion method against 
the selected bacteria. The results of this study revealed 
that the Moringa root herbal toothpaste has a higher 
antimicrobial potential than Oral-B herbal toothpaste 
against tooth plaque. It might be considered a good 
source of active agents in the formulation of medicinal 
toothpaste. 41 

Standard treatment involves scaling and root planing, 
often combined with adjunctive antibiotics. However, 
inappropriate antibiotic use may lead to resistance. 
Therefore, natural antibacterial agents with a lower risk 
of resistance, such as Moringa oleifera leaves, are of 
interest 3, 42. Results from the study by Sawant et al. 
showed that Moringa oleifera leaf extract demonstrated 
comparable efficacy to 1% chlorhexidine gel in reducing 
GI, PI, and papillary bleeding index when used as an 
adjunct to scaling and root planing with topical 
application 43. In conclusion, Moringa oleifera leaves 
have significant potential for further development as 
antibacterial agents, both as herbal medicines and as 
raw materials for pharmaceutical products 3. A study by 
Obeid et al. confirmed that Moringa oleifera leaves have 
an extraordinary effect on the remineralisation of 
dentin and cementum, and they have a promising ability 
to control dentinal hypersensitivity and form 

biomimetic cementum tissue. Clinical trials using 
Moringa oleifera leaves to control hypersensitivity 
sensation under deep restorative preparations and with 
root exposure will be of great dental value. 44.  

Conclusion 

Standard treatment involves scaling and root planing, 
often combined with adjunctive antibiotics. However, 
inappropriate antibiotic use may lead to resistance. 
Therefore, natural antibacterial agents with a lower risk 
of resistance, such as Moringa oleifera leaves, are of 
interest. M. oleifera contains active compounds such as 
flavonoids, tannins, saponins, alkaloids, phenolics, and 
triterpenoids which possess antibacterial effects; hence, 
it can be used as safe and cheap plant antimicrobial 
agent. Moringa oleifera leaf extracts appear to be potent 
anti-microbial, anti-inflammatory, anti-cancer agents 
against oral ailments, also having activity in enamel re-
mineralisation and preservation of root extraction 
sockets. As traditional medicine, it has potential in 
treating different oral soft tissue diseases. Further 
research on Moringa oleifera is needed to exploit the 
pharmacological uses for the management and 
prevention of oral disease. 

Conflict of Interest: The authors declare no potential 
conflict of interest concerning the contents, authorship, 
and/or publication of this article. 

Author Contributions: All authors have equal 
contributions in the preparation of the manuscript and 
compilation. 

Source of Support: Nil 

Funding: The authors declared that this study has 
received no financial support. 

Informed Consent Statement: Not applicable.  

Data Availability Statement: The data supporting this 
paper are available in the cited references.  

Ethical approval: Not applicable 

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