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Available online at ajdhs.com 

Asian Journal of Dental and Health Sciences 
Open Access to Pharmaceutical and Medical Research 

Copyright  © 2021 The  Author(s): This is an open-access article distributed under the terms of the CC BY-NC 4.0 
which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the 

original author and source are credited 
 

 

 

Application of Moringa oleifera in Dentistry 

Raghunandan Meena1, Sunil Kumar Prajapati2, Rajendra Nagar3, Omji Porwal4, Teena Nagar5, Vijay Kumar Tilak6, 
R. Jayakumararaj 7, Rajeshwar Kamal Kant Arya8, Ram Chand Dhakar*9  

1 Professor, Department of General Medicine, Jhalawar Medical College, Jhalawar, Rajasthan, India 

2 Professor, Institute of Pharmacy, Bundelkhand University, Jhansi, India 

3 Associate Professor, Department of Paediatrics, Jhalawar Medical College, Jhalawar, Rajasthan, India 

4 Professor, Department of Pharmacognosy, Faculty of Pharmacy, Tishk International University-Erbil, Kurdistan Region, Iraq 

5 Associate Professor, Department of Gynaecology, Jhalawar Medical College, Jhalawar, Rajasthan, India 

6 Apex Professional University, Pasighat, Arunachal Pradesh-791102, India  

7 PG Department of Botany, Government Arts College, Melur – 625106, Madurai District, TN, India 

8 Assistant Professor, Deparment of Pharma sciences, Kumaun University Nainital, India 

9 Hospital Pharmacy, SRG Hospital & Medical College Jhalawar, Rajasthan, India-326001 

 

Article Info: 
_________________________________________ 

Article History: 

Received 07 Nov 2021       
Reviewed 13 Dec 2021 
Accepted 18 Dec 2021 
Published 25 Dec 2021 

_________________________________________ 
Cite this article as:  

Meena R, Prajapati SK, Nagar R, Porwal O, Nagar 
T, Tilak VK, Jayakumararaj R, Arya RKK, Dhakar 
RC, Application of Moringa oleifera in Dentistry, 
Asian Journal of Dental and Health Sciences. 2021; 
1(1):10-13 

DOI: http://dx.doi.org/10.22270/ajdhs.v1i1.5                                  

Abstract 
___________________________________________________________________________________________________________________ 

All part of the Moringa tree is useful in some way and people depends on it for their livelihood. Oral 
diseases persist to be a major health problem all over the world. Various microorganisms are found to 
be the possible pathogens responsible for the oral diseases. The leaves of the Moringa tree are an 
excellent source of Nutrients like Minerals, Protein and Vitamins (A and C). Moringa tree has 
approximately 46 antioxidants and it is one of the cheapest sources of natural anti-oxidants. Anti-
oxidants supply the free atoms needed by the human body and mitigate the effect of free radicals. M. 
oleifera contains active compounds such as flavonoids, tannins, saponins, alkaloids, phenolics, and 
triterpenoids which possess antibacterial effects. Moringa oleifera has high mineral and protein 
content and has been previously investigated for its potential in treating different oral soft tissue 
diseases.  Present review summarises the various application of Moringa oleifera in the field of 
dentistry. 

Keywords: Moringa oleifera, Anti-oxidants, Oral diseases, dentistry 

 

*Address for Correspondence:   

Ram Chand Dhakar, Hospital Pharmacy, SRG Hospital & Medical College Jhalawar, Rajasthan, India-326001. Email: dhakar_rc@yahoo.co.in    

 

Introduction 

Moringa oleifera is the most widely cultivated pan-
tropical species of a monogeneric family, the 
Moringaceae, which is native to the sub-Himalayan 
tracts of India, Pakistan, Bangladesh and Afghanistan. 
Moringa oleifera is known by such regional names as 
benzolive, drumstick tree, kelor, marango, mlonge, 
mulangay, nébéday, saijhan, and sajna.1. Virtually every 
part of the tree is beneficial in some way and both rural 
and urban people depend on it for their livelihood. In 
developing tropical countries, Moringa trees have been 
used to combat malnutrition, especially among infants 

and nursing mothers 2,3. The leaves of the Moringa tree 
are an excellent source of Nutrients like Minerals, 
Protein and Vitamins (A and C) 4, 5, 6, Moringa has 
approximately 46 antioxidants and is one of the most 
powerful sources of natural anti-oxidants. Anti-oxidants 
supply the free atoms needed by the human body and 
mitigate the effect of free radicals. M. oleifera contains 
active compounds such as flavonoids, tannins, saponins, 
alkaloids, phenolics, and triterpenoids which possess 
antibacterial effects. 

 

 

                       Open Access                                                                         Review Article                                         DOI: http://dx.doi.org/10.22270/ajdhs.v1i1.5                                  

http://jddtonline.info/
http://dx.doi.org/10.22270/ajdhs.v1i1.5
https://orcid.org/0000-0001-8250-8489


Meena et al                                                                                                                                   Asian Journal of Dental and Health Sciences. 2021; 1(1):10-13 

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Figure 1: Various parts of Moringa Oleifera 7-14 

 

Moringa oleifera in Dentistry 

Moringa has approximately 46 antioxidants and is one 
of the most powerful sources of natural anti-oxidants. 
Anti-oxidants supply the free atoms needed by the 
human body and mitigate the effect of free radicals. M. 
oleifera contains active compounds such as flavonoids, 
tannins, saponins, alkaloids, phenolics, and 
triterpenoids which possess antibacterial effects hence 
it can be used as safe and cheap plant antimicrobial 
agent. 

The extract from leaves of Moringa oleifera has high 
mineral and protein content and its historic reputation 
as a traditional medicine for different diseases has been 
previously investigated for its potential in treating 
different oral soft tissue diseases 15, 16.  

Moringa oleifera extract contains the highest values of 
calcium and phosphate that are required for the 
remineralization process. Therefore Moringa oleifera 
extract is investigated by Younis et al for its ability to 
treat induced enamel lesion.17 Scanning electron 
microscopy revealed that Leaves extract of Moringa 
oleifera loaded-varnish groups IV & V showed the most 
re-establishment of normal enamel architecture. 
Elemental analysis of the treated surfaces of Groups IV 
and V showed the surfaces treated by Moringa oleifera 
leaf extract loaded-varnish groups had significantly 
higher Ca, P, and O deposition than the fluoride varnish 
group. Leaves extract of Moringa oleifera might be 
considered as a biomimetic material which having 
capacity to guiding enamel tissue remineralization.17 

Hanaa Elgamily et al carried out a study to assess the 
antibacterial and antifungal potentials of different parts 

of Moringa oleifera plant using different extraction 
methods in attempts to formulate natural dental 
remedies from this plant. The different extracts of 
different parts of Moringa oleifera showed an 
antibacterial effect against Staphylococcus 
aureus and Streptococcus mutans growth. The novel 
toothpaste of ethanolic leaves extract has antimicrobial 
and antifungal potential effects all selected strains.18 

Based on the results of the study by Risnayanti Anas et 
al, it can be concluded that there is an increase in the 
amount of calcium in the teeth after the application of 
Moringa oleifera based paste and Casein 
phosphopeptide-amorphous calcium phosphate (CPP-
ACP) application. Moringa oleifera based paste and CPP-
APP are effective to increasing calcium levels in teeth 
compared to the pre-test group.19 

Dental caries is closely related with cariogenic biofilm, 
an oral biofilm containing a high proportion 
of Streptococcus mutans 20. Generally, oral biofilm is 
structurally and functionally organized and contains a 
balance of normal flora and pathogenic bacteria like S. 
mutans 21. Su-Kyung Jwa has investigated the 
antimicrobial effects of the M. oleifera leaf extracts on S. 
mutans and formation of cariogenic biofilm. Extract 
from M. oleifera leaves was derived using distilled water 
(DW) and ethyl alcohol (EtOH). S. mutans susceptibility 
assays were performed for each extract. Cariogenic 
biofilm was formed with or without DW and EtOH 
extract, and cariogenic biofilm was treated with both 
extracts. Both extracts showed antimicrobial activity 
against S. mutans and inhibited formation of cariogenic 
biofilm. 22 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522384/#bib6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522384/#bib7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779079/#b11-pnfs-24-308
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779079/#b13-pnfs-24-308
https://www.ncbi.nlm.nih.gov/pubmed/?term=Jwa%20SK%5BAuthor%5D&cauthor=true&cauthor_uid=31608256


Meena et al                                                                                                                                   Asian Journal of Dental and Health Sciences. 2021; 1(1):10-13 

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Table 1: Application of Moringa oleifera in Dentistry 

S.N. Author Objective of study Application Ref 
1 Rao P K, et 

al 2011 
To assess the antibacterial 
activity of isolated 
compounds from 
M. oleifera against selected 
oral bacteria 

All the isolated compounds from M. oleifera were active 
against Streptococcus mutans (MTCC 497), 
Streptococcus salivarius, Lactobacillus fermentum, 
Streptococcus anginosus, Streptococcus gordonii, 
Lactobacillus acidophilus. 

23 

2 Hanaa 
Elgamily et 
al 2016 

To assess the antibacterial 
and antifungal potentials of 
different parts of Moringa 
oleifera  

For dental remedies, experimental toothpaste 
exhibited higher mean inhibition than the mouthwash 
against Staphylococcus aureus, Streptococcus 
mutans and only the toothpaste revealed antifungal 
effect against Candida albicans 

18 

4 Carranza J 
B, 2017 

To identify the secondary 
compounds of three 
varieties of Moringa oleifera 
Lam. Extracts namely; 
Native, Chinese, and Yard 
Long malunggay using 
phytochemical analysis 

The extracts of moringa varieties contain flavonoids, 
alkaloids and tannins that are known to have 
antimicrobial and anti-inflammatory properties; thus, 
these have potential natural components in the 
manufacture of toothpastes 

24 

5 Su-Kyung 
Jwa et 2019 

to investigate the 
antimicrobial effects of 
the M. oleifera leaf extracts 

extracts showed antimicrobial activity against S. 
mutans and inhibited formation of cariogenic biofilm 

22 

6 Piasti 
Sopandani 
et al 2020 

 to assess the antibacterial 
effect of M. oleifera extract as 
an irrigation solution 
against E. faecalis 

M. oleifera extract solution at concentrations of 75% 
and 100% is as effective as 5.25% NaOCl against E. 
faecalis 

25 

7 Mahassen M 
Farghaly et 
al 2020 

to formulate a nontoxic 
mouthwash from Moringa 
oleifera 

Moringa extract showing antibacterial and antiplaque 
effect will be used 

26 

8 Younis SH 
2020 

To assess the effect of 
Leaves extract of Moringa 
oleifera loaded-varnish 
groups IV & V on enamel  

Moringa leaf extract loaded-varnish groups had 
significantly higher Ca, P, and O deposition than the 
fluoride varnish group. Leaves extract of Moringa 
oleifera might be considered as a biomimetic material 
which having capacity to guiding enamel tissue 
remineralization 

17 

9 Anas R et al 
2021 

To study the Effectiveness of 
Paste Based Moringa oleifera 
To 
Increase Calcium Levels 
Human Tooth 

Results of this research showed that Moringa Oleifera 
paste has higher calcium level compared to Pre-test 
groups and  Moringa oleifera paste can be effective in 
increasing calcium levels of human teeth  

19 

10 Nawal 
Aidaros et 
al 2021 

To investigate and compare 
the effect of green tea, black 
tea and Moringa oleifera on 
artificially demineralized 
enamel and dentin 

In dentin, the highest mean value was found in Moringa 
oleifera. Study concluded that Moringa tree enhanced 
the remineralization process and thus, might be 
considered as an effective natural remineralizing 
agents 

27 

11 Buakaew et 
al 2021 

Moringa oleifera and 
Azadirachta indica were 
assessed for oral healthcare 
and gingivitis adjunctive 
treatment 

Author state that accumulative reduction percentages 
of both Staphylococcus spp. and Candida spp. were 
found and indicated that the herbal mouthwashes 
reduced Gingival index and plaque index and showed 
potential as oral healthcare products 

28 

 

 

Conclusion 

M. oleifera contains active compounds such as 
flavonoids, tannins, saponins, alkaloids, phenolics, and 
triterpenoids which possess antibacterial effects hence 
it can be used as safe and cheap plant antimicrobial 
agent. The extract from leaves of Moringa oleifera has 
high mineral and protein content. As traditional 
medicine it has potential in treating different oral soft 

tissue diseases. Study by Nawal Aidaros et al concluded 
that Moringa oleifera enhanced the remineralization 
process of demineralized enamel and dentin, and thus, 
might be considered as an effective natural 
remineralizing agent27. Further research on Moringa 
oleifera needed to exploit the pharmacological uses for 
management and prevention of oral disease. 

https://www.ncbi.nlm.nih.gov/pubmed/?term=Jwa%20SK%5BAuthor%5D&cauthor=true&cauthor_uid=31608256
https://www.ncbi.nlm.nih.gov/pubmed/?term=Jwa%20SK%5BAuthor%5D&cauthor=true&cauthor_uid=31608256
https://www.ncbi.nlm.nih.gov/pubmed/?term=Jwa%20SK%5BAuthor%5D&cauthor=true&cauthor_uid=31608256
https://www.scidentj.com/searchresult.asp?search=&author=Piasti+Sopandani&journal=Y&but_search=Search&entries=10&pg=1&s=0
https://www.scidentj.com/searchresult.asp?search=&author=Piasti+Sopandani&journal=Y&but_search=Search&entries=10&pg=1&s=0
https://www.scidentj.com/searchresult.asp?search=&author=Piasti+Sopandani&journal=Y&but_search=Search&entries=10&pg=1&s=0


Meena et al                                                                                                                                   Asian Journal of Dental and Health Sciences. 2021; 1(1):10-13 

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