id	sid	tid	token	lemma	pos
asodahs-128	1	1	emmanuel	emmanuel	PROPN
asodahs-128	1	2	ifeanyi	ifeanyi	PROPN
asodahs-128	1	3	obeagu	obeagu	PROPN
asodahs-128	1	4	asian	asian	PROPN
asodahs-128	1	5	journal	journal	PROPN
asodahs-128	1	6	of	of	ADP
asodahs-128	1	7	dental	dental	ADJ
asodahs-128	1	8	and	and	CCONJ
asodahs-128	1	9	health	health	NOUN
asodahs-128	1	10	sciences	science	NOUN
asodahs-128	1	11	.	.	PUNCT
asodahs-128	1	12	2025	2025	NUM
asodahs-128	1	13	;	;	PUNCT
asodahs-128	1	14	5(3):1	5(3):1	NUM
asodahs-128	1	15	-	-	SYM
asodahs-128	1	16	5	5	NUM
asodahs-128	1	17	[	[	X
asodahs-128	1	18	1	1	NUM
asodahs-128	1	19	]	]	PUNCT
asodahs-128	1	20	ajdhs.com	ajdhs.com	X
asodahs-128	1	21	available	available	ADJ
asodahs-128	1	22	online	online	ADV
asodahs-128	1	23	at	at	ADP
asodahs-128	1	24	ajdhs.com	ajdhs.com	X
asodahs-128	1	25	asian	asian	ADJ
asodahs-128	1	26	journal	journal	NOUN
asodahs-128	1	27	of	of	ADP
asodahs-128	1	28	dental	dental	ADJ
asodahs-128	1	29	and	and	CCONJ
asodahs-128	1	30	health	health	NOUN
asodahs-128	1	31	sciences	science	NOUN
asodahs-128	1	32	open	open	VERB
asodahs-128	1	33	access	access	NOUN
asodahs-128	1	34	to	to	ADP
asodahs-128	1	35	dental	dental	ADJ
asodahs-128	1	36	and	and	CCONJ
asodahs-128	1	37	medical	medical	ADJ
asodahs-128	1	38	research	research	NOUN
asodahs-128	1	39	copyright	copyright	NOUN
asodahs-128	1	40	©	©	ADP
asodahs-128	1	41	2025	2025	NUM
asodahs-128	1	42	the	the	DET
asodahs-128	1	43	author(s	author(s	NOUN
asodahs-128	1	44	):	):	PUNCT
asodahs-128	1	45	this	this	PRON
asodahs-128	1	46	is	be	AUX
asodahs-128	1	47	an	an	DET
asodahs-128	1	48	open	open	ADJ
asodahs-128	1	49	-	-	PUNCT
asodahs-128	1	50	access	access	NOUN
asodahs-128	1	51	article	article	NOUN
asodahs-128	1	52	distributed	distribute	VERB
asodahs-128	1	53	under	under	ADP
asodahs-128	1	54	the	the	DET
asodahs-128	1	55	terms	term	NOUN
asodahs-128	1	56	of	of	ADP
asodahs-128	1	57	the	the	DET
asodahs-128	1	58	cc	cc	PROPN
asodahs-128	1	59	by	by	ADP
asodahs-128	1	60	-	-	PUNCT
asodahs-128	1	61	nc	nc	PROPN
asodahs-128	1	62	4.0	4.0	NUM
asodahs-128	1	63	which	which	PRON
asodahs-128	1	64	permits	permit	VERB
asodahs-128	1	65	unrestricted	unrestricted	ADJ
asodahs-128	1	66	use	use	NOUN
asodahs-128	1	67	,	,	PUNCT
asodahs-128	1	68	distribution	distribution	NOUN
asodahs-128	1	69	,	,	PUNCT
asodahs-128	1	70	and	and	CCONJ
asodahs-128	1	71	reproduction	reproduction	NOUN
asodahs-128	1	72	in	in	ADP
asodahs-128	1	73	any	any	DET
asodahs-128	1	74	medium	medium	NOUN
asodahs-128	1	75	for	for	ADP
asodahs-128	1	76	non	non	ADJ
asodahs-128	1	77	-	-	ADJ
asodahs-128	1	78	commercial	commercial	ADJ
asodahs-128	1	79	use	use	NOUN
asodahs-128	1	80	provided	provide	VERB
asodahs-128	1	81	the	the	DET
asodahs-128	1	82	original	original	ADJ
asodahs-128	1	83	author	author	NOUN
asodahs-128	1	84	and	and	CCONJ
asodahs-128	1	85	source	source	NOUN
asodahs-128	1	86	are	be	AUX
asodahs-128	1	87	credited	credit	VERB
asodahs-128	1	88	nitrogen	nitrogen	NOUN
asodahs-128	1	89	balance	balance	NOUN
asodahs-128	1	90	and	and	CCONJ
asodahs-128	1	91	its	its	PRON
asodahs-128	1	92	impact	impact	NOUN
asodahs-128	1	93	on	on	ADP
asodahs-128	1	94	hematological	hematological	ADJ
asodahs-128	1	95	function	function	NOUN
asodahs-128	1	96	in	in	ADP
asodahs-128	1	97	sickle	sickle	NOUN
asodahs-128	1	98	cell	cell	NOUN
asodahs-128	1	99	patients	patient	NOUN
asodahs-128	1	100	:	:	PUNCT
asodahs-128	1	101	a	a	DET
asodahs-128	1	102	review	review	NOUN
asodahs-128	1	103	*	*	PUNCT
asodahs-128	1	104	emmanuel	emmanuel	PROPN
asodahs-128	1	105	ifeanyi	ifeanyi	PROPN
asodahs-128	1	106	obeagu	obeagu	PROPN
asodahs-128	1	107	department	department	PROPN
asodahs-128	1	108	of	of	ADP
asodahs-128	1	109	biomedical	biomedical	ADJ
asodahs-128	1	110	and	and	CCONJ
asodahs-128	1	111	laboratory	laboratory	NOUN
asodahs-128	1	112	science	science	PROPN
asodahs-128	1	113	,	,	PUNCT
asodahs-128	1	114	africa	africa	PROPN
asodahs-128	1	115	university	university	PROPN
asodahs-128	1	116	,	,	PUNCT
asodahs-128	1	117	zimbabwe	zimbabwe	PROPN
asodahs-128	1	118	.	.	PUNCT
asodahs-128	2	1	article	article	NOUN
asodahs-128	2	2	info	info	NOUN
asodahs-128	2	3	:	:	PUNCT
asodahs-128	3	1	_	_	PUNCT
asodahs-128	4	1	_	_	PUNCT
asodahs-128	5	1	_	_	PUNCT
asodahs-128	6	1	_	_	PUNCT
asodahs-128	7	1	_	_	PUNCT
asodahs-128	8	1	_	_	PUNCT
asodahs-128	9	1	_	_	PUNCT
asodahs-128	10	1	_	_	PUNCT
asodahs-128	11	1	_	_	PUNCT
asodahs-128	12	1	_	_	PUNCT
asodahs-128	13	1	_	_	PUNCT
asodahs-128	14	1	_	_	PUNCT
asodahs-128	15	1	_	_	PUNCT
asodahs-128	16	1	_	_	PUNCT
asodahs-128	17	1	_	_	PUNCT
asodahs-128	18	1	_	_	PUNCT
asodahs-128	19	1	_	_	PUNCT
asodahs-128	20	1	_	_	PUNCT
asodahs-128	21	1	_	_	PUNCT
asodahs-128	22	1	_	_	PUNCT
asodahs-128	23	1	_	_	PUNCT
asodahs-128	24	1	_	_	PUNCT
asodahs-128	25	1	_	_	PUNCT
asodahs-128	26	1	_	_	PUNCT
asodahs-128	27	1	_	_	PUNCT
asodahs-128	28	1	_	_	PUNCT
asodahs-128	29	1	_	_	PUNCT
asodahs-128	30	1	_	_	PUNCT
asodahs-128	31	1	_	_	PUNCT
asodahs-128	32	1	_	_	PUNCT
asodahs-128	33	1	_	_	PUNCT
asodahs-128	34	1	_	_	PUNCT
asodahs-128	35	1	_	_	PUNCT
asodahs-128	36	1	_	_	PUNCT
asodahs-128	37	1	_	_	PUNCT
asodahs-128	38	1	_	_	PUNCT
asodahs-128	39	1	_	_	PUNCT
asodahs-128	40	1	_	_	PUNCT
asodahs-128	41	1	_	_	PUNCT
asodahs-128	42	1	_	_	PUNCT
asodahs-128	43	1	_	_	PUNCT
asodahs-128	44	1	_	_	PUNCT
asodahs-128	45	1	_	_	PUNCT
asodahs-128	46	1	_	_	PUNCT
asodahs-128	47	1	_	_	PUNCT
asodahs-128	47	2	article	article	NOUN
asodahs-128	47	3	history	history	NOUN
asodahs-128	47	4	:	:	PUNCT
asodahs-128	47	5	received	receive	VERB
asodahs-128	47	6	09	09	NUM
asodahs-128	47	7	may	may	AUX
asodahs-128	47	8	2025	2025	NUM
asodahs-128	47	9	reviewed	review	VERB
asodahs-128	47	10	02	02	NUM
asodahs-128	47	11	june	june	PROPN
asodahs-128	47	12	2025	2025	NUM
asodahs-128	47	13	accepted	accept	VERB
asodahs-128	47	14	18	18	NUM
asodahs-128	47	15	june	june	PROPN
asodahs-128	47	16	2025	2025	NUM
asodahs-128	47	17	published	publish	VERB
asodahs-128	47	18	15	15	NUM
asodahs-128	47	19	sep	sep	NOUN
asodahs-128	47	20	2025	2025	NUM
asodahs-128	47	21	_	_	PUNCT
asodahs-128	48	1	_	_	PUNCT
asodahs-128	49	1	_	_	PUNCT
asodahs-128	50	1	_	_	PUNCT
asodahs-128	51	1	_	_	PUNCT
asodahs-128	52	1	_	_	PUNCT
asodahs-128	53	1	_	_	PUNCT
asodahs-128	54	1	_	_	PUNCT
asodahs-128	55	1	_	_	PUNCT
asodahs-128	56	1	_	_	PUNCT
asodahs-128	57	1	_	_	PUNCT
asodahs-128	58	1	_	_	PUNCT
asodahs-128	59	1	_	_	PUNCT
asodahs-128	60	1	_	_	PUNCT
asodahs-128	61	1	_	_	PUNCT
asodahs-128	62	1	_	_	PUNCT
asodahs-128	63	1	_	_	PUNCT
asodahs-128	64	1	_	_	PUNCT
asodahs-128	65	1	_	_	PUNCT
asodahs-128	66	1	_	_	PUNCT
asodahs-128	67	1	_	_	PUNCT
asodahs-128	68	1	_	_	PUNCT
asodahs-128	69	1	_	_	PUNCT
asodahs-128	70	1	_	_	PUNCT
asodahs-128	71	1	_	_	PUNCT
asodahs-128	72	1	_	_	PUNCT
asodahs-128	73	1	_	_	PUNCT
asodahs-128	74	1	_	_	PUNCT
asodahs-128	75	1	_	_	PUNCT
asodahs-128	76	1	_	_	PUNCT
asodahs-128	77	1	_	_	PUNCT
asodahs-128	78	1	_	_	PUNCT
asodahs-128	79	1	_	_	PUNCT
asodahs-128	80	1	_	_	PUNCT
asodahs-128	81	1	_	_	PUNCT
asodahs-128	82	1	_	_	PUNCT
asodahs-128	83	1	_	_	PUNCT
asodahs-128	84	1	_	_	PUNCT
asodahs-128	85	1	_	_	PUNCT
asodahs-128	86	1	_	_	PUNCT
asodahs-128	87	1	_	_	PUNCT
asodahs-128	88	1	_	_	PUNCT
asodahs-128	89	1	_	_	PUNCT
asodahs-128	90	1	_	_	PUNCT
asodahs-128	91	1	_	_	PUNCT
asodahs-128	91	2	cite	cite	VERB
asodahs-128	91	3	this	this	DET
asodahs-128	91	4	article	article	NOUN
asodahs-128	91	5	as	as	ADP
asodahs-128	91	6	:	:	PUNCT
asodahs-128	91	7	obeagu	obeagu	ADJ
asodahs-128	91	8	ei	ei	PROPN
asodahs-128	91	9	,	,	PUNCT
asodahs-128	91	10	nitrogen	nitrogen	NOUN
asodahs-128	91	11	balance	balance	NOUN
asodahs-128	91	12	and	and	CCONJ
asodahs-128	91	13	its	its	PRON
asodahs-128	91	14	impact	impact	NOUN
asodahs-128	91	15	on	on	ADP
asodahs-128	91	16	hematological	hematological	ADJ
asodahs-128	91	17	function	function	NOUN
asodahs-128	91	18	in	in	ADP
asodahs-128	91	19	sickle	sickle	NOUN
asodahs-128	91	20	cell	cell	NOUN
asodahs-128	91	21	patients	patient	NOUN
asodahs-128	91	22	:	:	PUNCT
asodahs-128	91	23	a	a	DET
asodahs-128	91	24	review	review	NOUN
asodahs-128	91	25	,	,	PUNCT
asodahs-128	91	26	asian	asian	ADJ
asodahs-128	91	27	journal	journal	NOUN
asodahs-128	91	28	of	of	ADP
asodahs-128	91	29	dental	dental	ADJ
asodahs-128	91	30	and	and	CCONJ
asodahs-128	91	31	health	health	NOUN
asodahs-128	91	32	sciences	science	NOUN
asodahs-128	91	33	.	.	PUNCT
asodahs-128	92	1	2025	2025	NUM
asodahs-128	92	2	;	;	PUNCT
asodahs-128	92	3	5(3):1	5(3):1	NUM
asodahs-128	92	4	-	-	SYM
asodahs-128	92	5	5	5	NUM
asodahs-128	92	6	doi	doi	NOUN
asodahs-128	92	7	:	:	PUNCT
asodahs-128	92	8	http://dx.doi.org/10.22270/ajdhs.v5i3.128	http://dx.doi.org/10.22270/ajdhs.v5i3.128	NOUN
asodahs-128	92	9	abstract	abstract	ADJ
asodahs-128	92	10	_	_	PUNCT
asodahs-128	93	1	_	_	PUNCT
asodahs-128	94	1	_	_	PUNCT
asodahs-128	95	1	_	_	PUNCT
asodahs-128	96	1	_	_	PUNCT
asodahs-128	97	1	_	_	PUNCT
asodahs-128	98	1	_	_	PUNCT
asodahs-128	99	1	_	_	PUNCT
asodahs-128	100	1	_	_	PUNCT
asodahs-128	101	1	_	_	PUNCT
asodahs-128	102	1	_	_	PUNCT
asodahs-128	103	1	_	_	PUNCT
asodahs-128	104	1	_	_	PUNCT
asodahs-128	105	1	_	_	PUNCT
asodahs-128	106	1	_	_	PUNCT
asodahs-128	107	1	_	_	PUNCT
asodahs-128	108	1	_	_	PUNCT
asodahs-128	109	1	_	_	PUNCT
asodahs-128	110	1	_	_	PUNCT
asodahs-128	111	1	_	_	PUNCT
asodahs-128	112	1	_	_	PUNCT
asodahs-128	113	1	_	_	PUNCT
asodahs-128	114	1	_	_	PUNCT
asodahs-128	115	1	_	_	PUNCT
asodahs-128	116	1	_	_	PUNCT
asodahs-128	117	1	_	_	PUNCT
asodahs-128	118	1	_	_	PUNCT
asodahs-128	119	1	_	_	PUNCT
asodahs-128	120	1	_	_	PUNCT
asodahs-128	121	1	_	_	PUNCT
asodahs-128	122	1	_	_	PUNCT
asodahs-128	123	1	_	_	PUNCT
asodahs-128	124	1	_	_	PUNCT
asodahs-128	125	1	_	_	PUNCT
asodahs-128	126	1	_	_	PUNCT
asodahs-128	127	1	_	_	PUNCT
asodahs-128	128	1	_	_	PUNCT
asodahs-128	129	1	_	_	PUNCT
asodahs-128	130	1	_	_	PUNCT
asodahs-128	131	1	_	_	PUNCT
asodahs-128	132	1	_	_	PUNCT
asodahs-128	133	1	_	_	PUNCT
asodahs-128	134	1	_	_	PUNCT
asodahs-128	135	1	_	_	PUNCT
asodahs-128	136	1	_	_	PUNCT
asodahs-128	137	1	_	_	PUNCT
asodahs-128	138	1	_	_	PUNCT
asodahs-128	139	1	_	_	PUNCT
asodahs-128	140	1	_	_	PUNCT
asodahs-128	141	1	_	_	PUNCT
asodahs-128	142	1	_	_	PUNCT
asodahs-128	143	1	_	_	PUNCT
asodahs-128	144	1	_	_	PUNCT
asodahs-128	145	1	_	_	PUNCT
asodahs-128	146	1	_	_	PUNCT
asodahs-128	147	1	_	_	PUNCT
asodahs-128	148	1	_	_	PUNCT
asodahs-128	149	1	_	_	PUNCT
asodahs-128	150	1	_	_	PUNCT
asodahs-128	151	1	_	_	PUNCT
asodahs-128	152	1	_	_	PUNCT
asodahs-128	153	1	_	_	PUNCT
asodahs-128	154	1	_	_	PUNCT
asodahs-128	155	1	_	_	PUNCT
asodahs-128	156	1	_	_	PUNCT
asodahs-128	157	1	_	_	PUNCT
asodahs-128	158	1	_	_	PUNCT
asodahs-128	159	1	_	_	PUNCT
asodahs-128	160	1	_	_	PUNCT
asodahs-128	161	1	_	_	PUNCT
asodahs-128	162	1	_	_	PUNCT
asodahs-128	163	1	_	_	PUNCT
asodahs-128	164	1	_	_	PUNCT
asodahs-128	165	1	_	_	PUNCT
asodahs-128	166	1	_	_	PUNCT
asodahs-128	167	1	_	_	PUNCT
asodahs-128	168	1	_	_	PUNCT
asodahs-128	169	1	_	_	PUNCT
asodahs-128	170	1	_	_	PUNCT
asodahs-128	171	1	_	_	PUNCT
asodahs-128	172	1	_	_	PUNCT
asodahs-128	173	1	_	_	PUNCT
asodahs-128	174	1	_	_	PUNCT
asodahs-128	175	1	_	_	PUNCT
asodahs-128	176	1	_	_	PUNCT
asodahs-128	177	1	_	_	PUNCT
asodahs-128	178	1	_	_	PUNCT
asodahs-128	179	1	_	_	PUNCT
asodahs-128	180	1	_	_	PUNCT
asodahs-128	181	1	_	_	PUNCT
asodahs-128	182	1	_	_	PUNCT
asodahs-128	183	1	_	_	PUNCT
asodahs-128	184	1	_	_	PUNCT
asodahs-128	185	1	_	_	PUNCT
asodahs-128	186	1	_	_	PUNCT
asodahs-128	187	1	_	_	PUNCT
asodahs-128	188	1	_	_	PUNCT
asodahs-128	189	1	_	_	PUNCT
asodahs-128	190	1	_	_	PUNCT
asodahs-128	191	1	_	_	PUNCT
asodahs-128	192	1	_	_	PUNCT
asodahs-128	193	1	_	_	PUNCT
asodahs-128	194	1	_	_	PUNCT
asodahs-128	195	1	_	_	PUNCT
asodahs-128	196	1	_	_	PUNCT
asodahs-128	197	1	_	_	PUNCT
asodahs-128	198	1	_	_	PUNCT
asodahs-128	199	1	_	_	PUNCT
asodahs-128	200	1	_	_	PUNCT
asodahs-128	201	1	_	_	PUNCT
asodahs-128	202	1	_	_	PUNCT
asodahs-128	203	1	_	_	PUNCT
asodahs-128	203	2	_	_	PUNCT
asodahs-128	203	3	sickle	sickle	NOUN
asodahs-128	203	4	cell	cell	NOUN
asodahs-128	203	5	disease	disease	NOUN
asodahs-128	203	6	(	(	PUNCT
asodahs-128	203	7	scd	scd	NOUN
asodahs-128	203	8	)	)	PUNCT
asodahs-128	203	9	is	be	AUX
asodahs-128	203	10	a	a	DET
asodahs-128	203	11	chronic	chronic	ADJ
asodahs-128	203	12	genetic	genetic	ADJ
asodahs-128	203	13	disorder	disorder	NOUN
asodahs-128	203	14	marked	mark	VERB
asodahs-128	203	15	by	by	ADP
asodahs-128	203	16	recurrent	recurrent	ADJ
asodahs-128	203	17	hemolysis	hemolysis	NOUN
asodahs-128	203	18	,	,	PUNCT
asodahs-128	203	19	anemia	anemia	NOUN
asodahs-128	203	20	,	,	PUNCT
asodahs-128	203	21	and	and	CCONJ
asodahs-128	203	22	vaso	vaso	NOUN
asodahs-128	203	23	-	-	PUNCT
asodahs-128	203	24	occlusive	occlusive	ADJ
asodahs-128	203	25	events	event	NOUN
asodahs-128	203	26	,	,	PUNCT
asodahs-128	203	27	all	all	PRON
asodahs-128	203	28	of	of	ADP
asodahs-128	203	29	which	which	PRON
asodahs-128	203	30	significantly	significantly	ADV
asodahs-128	203	31	elevate	elevate	VERB
asodahs-128	203	32	the	the	DET
asodahs-128	203	33	body	body	NOUN
asodahs-128	203	34	's	's	PART
asodahs-128	203	35	metabolic	metabolic	NOUN
asodahs-128	203	36	and	and	CCONJ
asodahs-128	203	37	nutritional	nutritional	ADJ
asodahs-128	203	38	demands	demand	NOUN
asodahs-128	203	39	.	.	PUNCT
asodahs-128	204	1	among	among	ADP
asodahs-128	204	2	the	the	DET
asodahs-128	204	3	critical	critical	ADJ
asodahs-128	204	4	nutritional	nutritional	ADJ
asodahs-128	204	5	parameters	parameter	NOUN
asodahs-128	204	6	,	,	PUNCT
asodahs-128	204	7	nitrogen	nitrogen	NOUN
asodahs-128	204	8	balance	balance	NOUN
asodahs-128	204	9	—	—	PUNCT
asodahs-128	204	10	reflecting	reflect	VERB
asodahs-128	204	11	the	the	DET
asodahs-128	204	12	equilibrium	equilibrium	NOUN
asodahs-128	204	13	between	between	ADP
asodahs-128	204	14	nitrogen	nitrogen	NOUN
asodahs-128	204	15	intake	intake	NOUN
asodahs-128	204	16	and	and	CCONJ
asodahs-128	204	17	excretion	excretion	NOUN
asodahs-128	204	18	—	—	PUNCT
asodahs-128	204	19	emerges	emerge	VERB
asodahs-128	204	20	as	as	ADP
asodahs-128	204	21	a	a	DET
asodahs-128	204	22	key	key	ADJ
asodahs-128	204	23	indicator	indicator	NOUN
asodahs-128	204	24	of	of	ADP
asodahs-128	204	25	protein	protein	NOUN
asodahs-128	204	26	metabolism	metabolism	NOUN
asodahs-128	204	27	and	and	CCONJ
asodahs-128	204	28	tissue	tissue	NOUN
asodahs-128	204	29	maintenance	maintenance	NOUN
asodahs-128	204	30	.	.	PUNCT
asodahs-128	205	1	patients	patient	NOUN
asodahs-128	205	2	with	with	ADP
asodahs-128	205	3	scd	scd	PROPN
asodahs-128	205	4	often	often	ADV
asodahs-128	205	5	face	face	VERB
asodahs-128	205	6	challenges	challenge	NOUN
asodahs-128	205	7	in	in	ADP
asodahs-128	205	8	maintaining	maintain	VERB
asodahs-128	205	9	adequate	adequate	ADJ
asodahs-128	205	10	nitrogen	nitrogen	NOUN
asodahs-128	205	11	balance	balance	NOUN
asodahs-128	205	12	due	due	ADP
asodahs-128	205	13	to	to	ADP
asodahs-128	205	14	chronic	chronic	ADJ
asodahs-128	205	15	inflammation	inflammation	NOUN
asodahs-128	205	16	,	,	PUNCT
asodahs-128	205	17	increased	increase	VERB
asodahs-128	205	18	erythropoietic	erythropoietic	ADJ
asodahs-128	205	19	drive	drive	NOUN
asodahs-128	205	20	,	,	PUNCT
asodahs-128	205	21	and	and	CCONJ
asodahs-128	205	22	elevated	elevated	ADJ
asodahs-128	205	23	protein	protein	NOUN
asodahs-128	205	24	turnover	turnover	NOUN
asodahs-128	205	25	,	,	PUNCT
asodahs-128	205	26	particularly	particularly	ADV
asodahs-128	205	27	during	during	ADP
asodahs-128	205	28	disease	disease	NOUN
asodahs-128	205	29	exacerbations	exacerbation	NOUN
asodahs-128	205	30	or	or	CCONJ
asodahs-128	205	31	infections	infection	NOUN
asodahs-128	205	32	.	.	PUNCT
asodahs-128	206	1	negative	negative	ADJ
asodahs-128	206	2	nitrogen	nitrogen	NOUN
asodahs-128	206	3	balance	balance	NOUN
asodahs-128	206	4	in	in	ADP
asodahs-128	206	5	scd	scd	PROPN
asodahs-128	206	6	is	be	AUX
asodahs-128	206	7	associated	associate	VERB
asodahs-128	206	8	with	with	ADP
asodahs-128	206	9	several	several	ADJ
asodahs-128	206	10	hematological	hematological	ADJ
asodahs-128	206	11	complications	complication	NOUN
asodahs-128	206	12	,	,	PUNCT
asodahs-128	206	13	including	include	VERB
asodahs-128	206	14	impaired	impaired	ADJ
asodahs-128	206	15	hemoglobin	hemoglobin	NOUN
asodahs-128	206	16	synthesis	synthesis	NOUN
asodahs-128	206	17	,	,	PUNCT
asodahs-128	206	18	decreased	decrease	VERB
asodahs-128	206	19	red	red	ADJ
asodahs-128	206	20	blood	blood	NOUN
asodahs-128	206	21	cell	cell	NOUN
asodahs-128	206	22	production	production	NOUN
asodahs-128	206	23	,	,	PUNCT
asodahs-128	206	24	and	and	CCONJ
asodahs-128	206	25	weakened	weaken	VERB
asodahs-128	206	26	immune	immune	ADJ
asodahs-128	206	27	defense	defense	NOUN
asodahs-128	206	28	.	.	PUNCT
asodahs-128	207	1	the	the	DET
asodahs-128	207	2	continuous	continuous	ADJ
asodahs-128	207	3	need	need	NOUN
asodahs-128	207	4	for	for	ADP
asodahs-128	207	5	red	red	ADJ
asodahs-128	207	6	blood	blood	NOUN
asodahs-128	207	7	cell	cell	NOUN
asodahs-128	207	8	replacement	replacement	NOUN
asodahs-128	207	9	due	due	ADP
asodahs-128	207	10	to	to	ADP
asodahs-128	207	11	chronic	chronic	ADJ
asodahs-128	207	12	hemolysis	hemolysis	NOUN
asodahs-128	207	13	further	far	ADV
asodahs-128	207	14	amplifies	amplify	VERB
asodahs-128	207	15	the	the	DET
asodahs-128	207	16	demand	demand	NOUN
asodahs-128	207	17	for	for	ADP
asodahs-128	207	18	amino	amino	ADJ
asodahs-128	207	19	acids	acid	NOUN
asodahs-128	207	20	,	,	PUNCT
asodahs-128	207	21	making	make	VERB
asodahs-128	207	22	protein	protein	NOUN
asodahs-128	207	23	sufficiency	sufficiency	NOUN
asodahs-128	207	24	essential	essential	ADJ
asodahs-128	207	25	for	for	ADP
asodahs-128	207	26	effective	effective	ADJ
asodahs-128	207	27	hematopoiesis	hematopoiesis	NOUN
asodahs-128	207	28	.	.	PUNCT
asodahs-128	208	1	furthermore	furthermore	ADV
asodahs-128	208	2	,	,	PUNCT
asodahs-128	208	3	nitrogen	nitrogen	NOUN
asodahs-128	208	4	depletion	depletion	NOUN
asodahs-128	208	5	can	can	AUX
asodahs-128	208	6	worsen	worsen	VERB
asodahs-128	208	7	the	the	DET
asodahs-128	208	8	overall	overall	ADJ
asodahs-128	208	9	clinical	clinical	ADJ
asodahs-128	208	10	picture	picture	NOUN
asodahs-128	208	11	by	by	ADP
asodahs-128	208	12	contributing	contribute	VERB
asodahs-128	208	13	to	to	ADP
asodahs-128	208	14	growth	growth	NOUN
asodahs-128	208	15	delays	delay	NOUN
asodahs-128	208	16	in	in	ADP
asodahs-128	208	17	children	child	NOUN
asodahs-128	208	18	,	,	PUNCT
asodahs-128	208	19	reduced	reduce	VERB
asodahs-128	208	20	physical	physical	ADJ
asodahs-128	208	21	endurance	endurance	NOUN
asodahs-128	208	22	,	,	PUNCT
asodahs-128	208	23	and	and	CCONJ
asodahs-128	208	24	increased	increase	VERB
asodahs-128	208	25	frequency	frequency	NOUN
asodahs-128	208	26	of	of	ADP
asodahs-128	208	27	hospital	hospital	NOUN
asodahs-128	208	28	admissions	admission	NOUN
asodahs-128	208	29	.	.	PUNCT
asodahs-128	209	1	keywords	keyword	NOUN
asodahs-128	209	2	:	:	PUNCT
asodahs-128	209	3	nitrogen	nitrogen	NOUN
asodahs-128	209	4	balance	balance	NOUN
asodahs-128	209	5	,	,	PUNCT
asodahs-128	209	6	hematological	hematological	ADJ
asodahs-128	209	7	function	function	NOUN
asodahs-128	209	8	,	,	PUNCT
asodahs-128	209	9	sickle	sickle	NOUN
asodahs-128	209	10	cell	cell	NOUN
asodahs-128	209	11	disease	disease	NOUN
asodahs-128	209	12	,	,	PUNCT
asodahs-128	209	13	protein	protein	NOUN
asodahs-128	209	14	metabolism	metabolism	NOUN
asodahs-128	209	15	,	,	PUNCT
asodahs-128	209	16	anemia	anemia	NOUN
asodahs-128	209	17	*	*	NOUN
asodahs-128	209	18	address	address	NOUN
asodahs-128	209	19	for	for	ADP
asodahs-128	209	20	correspondence	correspondence	NOUN
asodahs-128	209	21	:	:	PUNCT
asodahs-128	209	22	e	e	PROPN
asodahs-128	209	23	emmanuel	emmanuel	PROPN
asodahs-128	209	24	ifeanyi	ifeanyi	PROPN
asodahs-128	209	25	obeagu	obeagu	PROPN
asodahs-128	209	26	,	,	PUNCT
asodahs-128	209	27	department	department	NOUN
asodahs-128	209	28	of	of	ADP
asodahs-128	209	29	biomedical	biomedical	ADJ
asodahs-128	209	30	and	and	CCONJ
asodahs-128	209	31	laboratory	laboratory	NOUN
asodahs-128	209	32	science	science	PROPN
asodahs-128	209	33	,	,	PUNCT
asodahs-128	209	34	africa	africa	PROPN
asodahs-128	209	35	university	university	PROPN
asodahs-128	209	36	,	,	PUNCT
asodahs-128	209	37	zimbabwe	zimbabwe	ADJ
asodahs-128	209	38	introduction	introduction	NOUN
asodahs-128	209	39	sickle	sickle	NOUN
asodahs-128	209	40	cell	cell	NOUN
asodahs-128	209	41	disease	disease	NOUN
asodahs-128	209	42	(	(	PUNCT
asodahs-128	209	43	scd	scd	NOUN
asodahs-128	209	44	)	)	PUNCT
asodahs-128	209	45	is	be	AUX
asodahs-128	209	46	an	an	DET
asodahs-128	209	47	inherited	inherit	VERB
asodahs-128	209	48	hemoglobinopathy	hemoglobinopathy	NOUN
asodahs-128	209	49	characterized	characterize	VERB
asodahs-128	209	50	by	by	ADP
asodahs-128	209	51	the	the	DET
asodahs-128	209	52	presence	presence	NOUN
asodahs-128	209	53	of	of	ADP
asodahs-128	209	54	sickle	sickle	NOUN
asodahs-128	209	55	-	-	PUNCT
asodahs-128	209	56	shaped	shape	VERB
asodahs-128	209	57	erythrocytes	erythrocyte	NOUN
asodahs-128	209	58	due	due	ADJ
asodahs-128	209	59	to	to	ADP
asodahs-128	209	60	a	a	DET
asodahs-128	209	61	mutation	mutation	NOUN
asodahs-128	209	62	in	in	ADP
asodahs-128	209	63	the	the	DET
asodahs-128	209	64	βglobin	βglobin	PROPN
asodahs-128	209	65	gene	gene	NOUN
asodahs-128	209	66	,	,	PUNCT
asodahs-128	209	67	resulting	result	VERB
asodahs-128	209	68	in	in	ADP
asodahs-128	209	69	the	the	DET
asodahs-128	209	70	production	production	NOUN
asodahs-128	209	71	of	of	ADP
asodahs-128	209	72	abnormal	abnormal	ADJ
asodahs-128	209	73	hemoglobin	hemoglobin	NOUN
asodahs-128	209	74	s	s	PART
asodahs-128	209	75	(	(	PUNCT
asodahs-128	209	76	hbs	hbs	PROPN
asodahs-128	209	77	)	)	PUNCT
asodahs-128	209	78	.	.	PUNCT
asodahs-128	210	1	this	this	DET
asodahs-128	210	2	structural	structural	ADJ
asodahs-128	210	3	abnormality	abnormality	NOUN
asodahs-128	210	4	leads	lead	VERB
asodahs-128	210	5	to	to	ADP
asodahs-128	210	6	red	red	ADJ
asodahs-128	210	7	blood	blood	NOUN
asodahs-128	210	8	cell	cell	NOUN
asodahs-128	210	9	deformation	deformation	NOUN
asodahs-128	210	10	under	under	ADP
asodahs-128	210	11	deoxygenated	deoxygenate	VERB
asodahs-128	210	12	conditions	condition	NOUN
asodahs-128	210	13	,	,	PUNCT
asodahs-128	210	14	causing	cause	VERB
asodahs-128	210	15	vaso	vaso	NOUN
asodahs-128	210	16	-	-	PUNCT
asodahs-128	210	17	occlusion	occlusion	NOUN
asodahs-128	210	18	,	,	PUNCT
asodahs-128	210	19	chronic	chronic	ADJ
asodahs-128	210	20	hemolytic	hemolytic	ADJ
asodahs-128	210	21	anemia	anemia	NOUN
asodahs-128	210	22	,	,	PUNCT
asodahs-128	210	23	and	and	CCONJ
asodahs-128	210	24	multi	multi	ADJ
asodahs-128	210	25	-	-	ADJ
asodahs-128	210	26	organ	organ	ADJ
asodahs-128	210	27	complications	complication	NOUN
asodahs-128	210	28	.	.	PUNCT
asodahs-128	211	1	scd	scd	PROPN
asodahs-128	211	2	predominantly	predominantly	ADV
asodahs-128	211	3	affects	affect	VERB
asodahs-128	211	4	individuals	individual	NOUN
asodahs-128	211	5	of	of	ADP
asodahs-128	211	6	african	african	ADJ
asodahs-128	211	7	,	,	PUNCT
asodahs-128	211	8	middle	middle	ADJ
asodahs-128	211	9	eastern	eastern	ADJ
asodahs-128	211	10	,	,	PUNCT
asodahs-128	211	11	and	and	CCONJ
asodahs-128	211	12	mediterranean	mediterranean	PROPN
asodahs-128	211	13	descent	descent	NOUN
asodahs-128	211	14	,	,	PUNCT
asodahs-128	211	15	and	and	CCONJ
asodahs-128	211	16	despite	despite	SCONJ
asodahs-128	211	17	advances	advance	NOUN
asodahs-128	211	18	in	in	ADP
asodahs-128	211	19	treatment	treatment	NOUN
asodahs-128	211	20	,	,	PUNCT
asodahs-128	211	21	it	it	PRON
asodahs-128	211	22	remains	remain	VERB
asodahs-128	211	23	a	a	DET
asodahs-128	211	24	major	major	ADJ
asodahs-128	211	25	contributor	contributor	NOUN
asodahs-128	211	26	to	to	ADP
asodahs-128	211	27	morbidity	morbidity	NOUN
asodahs-128	211	28	and	and	CCONJ
asodahs-128	211	29	mortality	mortality	NOUN
asodahs-128	211	30	in	in	ADP
asodahs-128	211	31	affected	affected	ADJ
asodahs-128	211	32	populations	population	NOUN
asodahs-128	211	33	.	.	PUNCT
asodahs-128	212	1	nutritional	nutritional	ADJ
asodahs-128	212	2	deficiencies	deficiency	NOUN
asodahs-128	212	3	,	,	PUNCT
asodahs-128	212	4	though	though	SCONJ
asodahs-128	212	5	often	often	ADV
asodahs-128	212	6	under	under	ADV
asodahs-128	212	7	-	-	PUNCT
asodahs-128	212	8	recognized	recognize	VERB
asodahs-128	212	9	,	,	PUNCT
asodahs-128	212	10	significantly	significantly	ADV
asodahs-128	212	11	impact	impact	VERB
asodahs-128	212	12	the	the	DET
asodahs-128	212	13	clinical	clinical	ADJ
asodahs-128	212	14	course	course	NOUN
asodahs-128	212	15	of	of	ADP
asodahs-128	212	16	scd	scd	PROPN
asodahs-128	212	17	1	1	NUM
asodahs-128	212	18	-	-	SYM
asodahs-128	212	19	6	6	NUM
asodahs-128	212	20	.	.	PUNCT
asodahs-128	213	1	one	one	NUM
asodahs-128	213	2	of	of	ADP
asodahs-128	213	3	the	the	DET
asodahs-128	213	4	less	less	ADV
asodahs-128	213	5	explored	explored	ADJ
asodahs-128	213	6	but	but	CCONJ
asodahs-128	213	7	highly	highly	ADV
asodahs-128	213	8	relevant	relevant	ADJ
asodahs-128	213	9	aspects	aspect	NOUN
asodahs-128	213	10	of	of	ADP
asodahs-128	213	11	nutritional	nutritional	ADJ
asodahs-128	213	12	status	status	NOUN
asodahs-128	213	13	in	in	ADP
asodahs-128	213	14	scd	scd	PROPN
asodahs-128	213	15	is	be	AUX
asodahs-128	213	16	nitrogen	nitrogen	NOUN
asodahs-128	213	17	balance	balance	NOUN
asodahs-128	213	18	.	.	PUNCT
asodahs-128	214	1	nitrogen	nitrogen	NOUN
asodahs-128	214	2	,	,	PUNCT
asodahs-128	214	3	a	a	DET
asodahs-128	214	4	fundamental	fundamental	ADJ
asodahs-128	214	5	component	component	NOUN
asodahs-128	214	6	of	of	ADP
asodahs-128	214	7	amino	amino	ADJ
asodahs-128	214	8	acids	acid	NOUN
asodahs-128	214	9	and	and	CCONJ
asodahs-128	214	10	nucleotides	nucleotide	NOUN
asodahs-128	214	11	,	,	PUNCT
asodahs-128	214	12	is	be	AUX
asodahs-128	214	13	vital	vital	ADJ
asodahs-128	214	14	for	for	ADP
asodahs-128	214	15	cellular	cellular	ADJ
asodahs-128	214	16	function	function	NOUN
asodahs-128	214	17	,	,	PUNCT
asodahs-128	214	18	growth	growth	NOUN
asodahs-128	214	19	,	,	PUNCT
asodahs-128	214	20	and	and	CCONJ
asodahs-128	214	21	repair	repair	NOUN
asodahs-128	214	22	.	.	PUNCT
asodahs-128	215	1	nitrogen	nitrogen	NOUN
asodahs-128	215	2	balance	balance	NOUN
asodahs-128	215	3	refers	refer	VERB
asodahs-128	215	4	to	to	ADP
asodahs-128	215	5	the	the	DET
asodahs-128	215	6	net	net	ADJ
asodahs-128	215	7	difference	difference	NOUN
asodahs-128	215	8	between	between	ADP
asodahs-128	215	9	nitrogen	nitrogen	NOUN
asodahs-128	215	10	intake	intake	NOUN
asodahs-128	215	11	—	—	PUNCT
asodahs-128	215	12	primarily	primarily	ADV
asodahs-128	215	13	through	through	ADP
asodahs-128	215	14	dietary	dietary	ADJ
asodahs-128	215	15	protein	protein	NOUN
asodahs-128	215	16	—	—	PUNCT
asodahs-128	215	17	and	and	CCONJ
asodahs-128	215	18	nitrogen	nitrogen	NOUN
asodahs-128	215	19	loss	loss	NOUN
asodahs-128	215	20	via	via	ADP
asodahs-128	215	21	urine	urine	NOUN
asodahs-128	215	22	,	,	PUNCT
asodahs-128	215	23	feces	fece	NOUN
asodahs-128	215	24	,	,	PUNCT
asodahs-128	215	25	sweat	sweat	NOUN
asodahs-128	215	26	,	,	PUNCT
asodahs-128	215	27	and	and	CCONJ
asodahs-128	215	28	other	other	ADJ
asodahs-128	215	29	bodily	bodily	ADJ
asodahs-128	215	30	excretions	excretion	NOUN
asodahs-128	215	31	.	.	PUNCT
asodahs-128	216	1	a	a	DET
asodahs-128	216	2	positive	positive	ADJ
asodahs-128	216	3	nitrogen	nitrogen	NOUN
asodahs-128	216	4	balance	balance	NOUN
asodahs-128	216	5	is	be	AUX
asodahs-128	216	6	indicative	indicative	ADJ
asodahs-128	216	7	of	of	ADP
asodahs-128	216	8	anabolic	anabolic	NOUN
asodahs-128	216	9	states	state	NOUN
asodahs-128	216	10	such	such	ADJ
asodahs-128	216	11	as	as	ADP
asodahs-128	216	12	growth	growth	NOUN
asodahs-128	216	13	,	,	PUNCT
asodahs-128	216	14	recovery	recovery	NOUN
asodahs-128	216	15	,	,	PUNCT
asodahs-128	216	16	or	or	CCONJ
asodahs-128	216	17	pregnancy	pregnancy	NOUN
asodahs-128	216	18	,	,	PUNCT
asodahs-128	216	19	whereas	whereas	SCONJ
asodahs-128	216	20	a	a	DET
asodahs-128	216	21	negative	negative	ADJ
asodahs-128	216	22	nitrogen	nitrogen	NOUN
asodahs-128	216	23	balance	balance	NOUN
asodahs-128	216	24	denotes	denote	VERB
asodahs-128	216	25	catabolism	catabolism	NOUN
asodahs-128	216	26	and	and	CCONJ
asodahs-128	216	27	potential	potential	ADJ
asodahs-128	216	28	physiological	physiological	ADJ
asodahs-128	216	29	deterioration	deterioration	NOUN
asodahs-128	216	30	7	7	NUM
asodahs-128	216	31	-	-	SYM
asodahs-128	216	32	8	8	NUM
asodahs-128	216	33	.	.	PUNCT
asodahs-128	217	1	patients	patient	NOUN
asodahs-128	217	2	with	with	ADP
asodahs-128	217	3	scd	scd	PROPN
asodahs-128	217	4	are	be	AUX
asodahs-128	217	5	particularly	particularly	ADV
asodahs-128	217	6	susceptible	susceptible	ADJ
asodahs-128	217	7	to	to	ADP
asodahs-128	217	8	a	a	DET
asodahs-128	217	9	negative	negative	ADJ
asodahs-128	217	10	nitrogen	nitrogen	NOUN
asodahs-128	217	11	balance	balance	NOUN
asodahs-128	217	12	due	due	ADP
asodahs-128	217	13	to	to	ADP
asodahs-128	217	14	several	several	ADJ
asodahs-128	217	15	interrelated	interrelated	ADJ
asodahs-128	217	16	factors	factor	NOUN
asodahs-128	217	17	.	.	PUNCT
asodahs-128	218	1	chronic	chronic	ADJ
asodahs-128	218	2	hemolysis	hemolysis	NOUN
asodahs-128	218	3	increases	increase	VERB
asodahs-128	218	4	the	the	DET
asodahs-128	218	5	demand	demand	NOUN
asodahs-128	218	6	for	for	ADP
asodahs-128	218	7	erythropoiesis	erythropoiesis	NOUN
asodahs-128	218	8	,	,	PUNCT
asodahs-128	218	9	which	which	PRON
asodahs-128	218	10	in	in	ADP
asodahs-128	218	11	turn	turn	NOUN
asodahs-128	218	12	escalates	escalate	VERB
asodahs-128	218	13	the	the	DET
asodahs-128	218	14	requirement	requirement	NOUN
asodahs-128	218	15	for	for	ADP
asodahs-128	218	16	amino	amino	ADJ
asodahs-128	218	17	acids	acid	NOUN
asodahs-128	218	18	and	and	CCONJ
asodahs-128	218	19	other	other	ADJ
asodahs-128	218	20	nutrients	nutrient	NOUN
asodahs-128	218	21	necessary	necessary	ADJ
asodahs-128	218	22	for	for	ADP
asodahs-128	218	23	red	red	ADJ
asodahs-128	218	24	blood	blood	NOUN
asodahs-128	218	25	cell	cell	NOUN
asodahs-128	218	26	synthesis	synthesis	NOUN
asodahs-128	218	27	.	.	PUNCT
asodahs-128	219	1	additionally	additionally	ADV
asodahs-128	219	2	,	,	PUNCT
asodahs-128	219	3	recurring	recur	VERB
asodahs-128	219	4	infections	infection	NOUN
asodahs-128	219	5	,	,	PUNCT
asodahs-128	219	6	systemic	systemic	ADJ
asodahs-128	219	7	inflammation	inflammation	NOUN
asodahs-128	219	8	,	,	PUNCT
asodahs-128	219	9	oxidative	oxidative	ADJ
asodahs-128	219	10	stress	stress	NOUN
asodahs-128	219	11	,	,	PUNCT
asodahs-128	219	12	and	and	CCONJ
asodahs-128	219	13	frequent	frequent	ADJ
asodahs-128	219	14	hospitalizations	hospitalization	NOUN
asodahs-128	219	15	contribute	contribute	VERB
asodahs-128	219	16	to	to	ADP
asodahs-128	219	17	hypermetabolism	hypermetabolism	NOUN
asodahs-128	219	18	and	and	CCONJ
asodahs-128	219	19	increased	increase	VERB
asodahs-128	219	20	protein	protein	NOUN
asodahs-128	219	21	turnover	turnover	NOUN
asodahs-128	219	22	.	.	PUNCT
asodahs-128	220	1	these	these	DET
asodahs-128	220	2	factors	factor	NOUN
asodahs-128	220	3	collectively	collectively	ADV
asodahs-128	220	4	shift	shift	VERB
asodahs-128	220	5	the	the	DET
asodahs-128	220	6	metabolic	metabolic	NOUN
asodahs-128	220	7	equilibrium	equilibrium	NOUN
asodahs-128	220	8	toward	toward	ADP
asodahs-128	220	9	a	a	DET
asodahs-128	220	10	catabolic	catabolic	ADJ
asodahs-128	220	11	state	state	NOUN
asodahs-128	220	12	,	,	PUNCT
asodahs-128	220	13	exacerbating	exacerbate	VERB
asodahs-128	220	14	nitrogen	nitrogen	NOUN
asodahs-128	220	15	loss	loss	NOUN
asodahs-128	220	16	and	and	CCONJ
asodahs-128	220	17	depleting	deplete	VERB
asodahs-128	220	18	protein	protein	NOUN
asodahs-128	220	19	reserves	reserve	NOUN
asodahs-128	220	20	critical	critical	ADJ
asodahs-128	220	21	for	for	ADP
asodahs-128	220	22	hematological	hematological	ADJ
asodahs-128	220	23	function	function	NOUN
asodahs-128	220	24	9	9	NUM
asodahs-128	220	25	-	-	SYM
asodahs-128	220	26	11	11	NUM
asodahs-128	220	27	.	.	PUNCT
asodahs-128	221	1	the	the	DET
asodahs-128	221	2	implications	implication	NOUN
asodahs-128	221	3	of	of	ADP
asodahs-128	221	4	a	a	DET
asodahs-128	221	5	disrupted	disrupt	VERB
asodahs-128	221	6	nitrogen	nitrogen	NOUN
asodahs-128	221	7	balance	balance	NOUN
asodahs-128	221	8	in	in	ADP
asodahs-128	221	9	scd	scd	PROPN
asodahs-128	221	10	extend	extend	VERB
asodahs-128	221	11	beyond	beyond	ADP
asodahs-128	221	12	basic	basic	ADJ
asodahs-128	221	13	nutrition	nutrition	NOUN
asodahs-128	221	14	.	.	PUNCT
asodahs-128	222	1	inadequate	inadequate	ADJ
asodahs-128	222	2	protein	protein	NOUN
asodahs-128	222	3	availability	availability	NOUN
asodahs-128	222	4	may	may	AUX
asodahs-128	222	5	hinder	hinder	VERB
asodahs-128	222	6	the	the	DET
asodahs-128	222	7	synthesis	synthesis	NOUN
asodahs-128	222	8	of	of	ADP
asodahs-128	222	9	hemoglobin	hemoglobin	NOUN
asodahs-128	222	10	,	,	PUNCT
asodahs-128	222	11	reduce	reduce	VERB
asodahs-128	222	12	erythrocyte	erythrocyte	NOUN
asodahs-128	222	13	lifespan	lifespan	NOUN
asodahs-128	222	14	,	,	PUNCT
asodahs-128	222	15	and	and	CCONJ
asodahs-128	222	16	impair	impair	NOUN
asodahs-128	222	17	bone	bone	NOUN
asodahs-128	222	18	marrow	marrow	NOUN
asodahs-128	222	19	function	function	NOUN
asodahs-128	222	20	.	.	PUNCT
asodahs-128	223	1	this	this	PRON
asodahs-128	223	2	can	can	AUX
asodahs-128	223	3	lead	lead	VERB
asodahs-128	223	4	to	to	ADP
asodahs-128	223	5	worsened	worsen	VERB
asodahs-128	223	6	anemia	anemia	NOUN
asodahs-128	223	7	,	,	PUNCT
asodahs-128	223	8	decreased	decrease	VERB
asodahs-128	223	9	immune	immune	ADJ
asodahs-128	223	10	response	response	NOUN
asodahs-128	223	11	,	,	PUNCT
asodahs-128	223	12	and	and	CCONJ
asodahs-128	223	13	slower	slow	ADJ
asodahs-128	223	14	recovery	recovery	NOUN
asodahs-128	223	15	from	from	ADP
asodahs-128	223	16	vasoocclusive	vasoocclusive	ADJ
asodahs-128	223	17	crises	crisis	NOUN
asodahs-128	223	18	or	or	CCONJ
asodahs-128	223	19	other	other	ADJ
asodahs-128	223	20	complications	complication	NOUN
asodahs-128	223	21	.	.	PUNCT
asodahs-128	224	1	moreover	moreover	ADV
asodahs-128	224	2	,	,	PUNCT
asodahs-128	224	3	in	in	ADP
asodahs-128	224	4	pediatric	pediatric	ADJ
asodahs-128	224	5	populations	population	NOUN
asodahs-128	224	6	,	,	PUNCT
asodahs-128	224	7	persistent	persistent	ADJ
asodahs-128	224	8	nitrogen	nitrogen	NOUN
asodahs-128	224	9	imbalance	imbalance	NOUN
asodahs-128	224	10	is	be	AUX
asodahs-128	224	11	associated	associate	VERB
asodahs-128	224	12	with	with	ADP
asodahs-128	224	13	growth	growth	NOUN
asodahs-128	224	14	retardation	retardation	NOUN
asodahs-128	224	15	,	,	PUNCT
asodahs-128	224	16	delayed	delay	VERB
asodahs-128	224	17	sexual	sexual	ADJ
asodahs-128	224	18	maturation	maturation	NOUN
asodahs-128	224	19	,	,	PUNCT
asodahs-128	224	20	and	and	CCONJ
asodahs-128	224	21	poor	poor	ADJ
asodahs-128	224	22	neurocognitive	neurocognitive	ADJ
asodahs-128	224	23	development	development	NOUN
asodahs-128	224	24	,	,	PUNCT
asodahs-128	224	25	further	far	ADV
asodahs-128	224	26	underscoring	underscore	VERB
asodahs-128	224	27	the	the	DET
asodahs-128	224	28	systemic	systemic	ADJ
asodahs-128	224	29	consequences	consequence	NOUN
asodahs-128	224	30	of	of	ADP
asodahs-128	224	31	poor	poor	ADJ
asodahs-128	224	32	nitrogen	nitrogen	NOUN
asodahs-128	224	33	homeostasis	homeostasis	NOUN
asodahs-128	224	34	12	12	NUM
asodahs-128	224	35	-	-	SYM
asodahs-128	224	36	15	15	NUM
asodahs-128	224	37	.	.	PUNCT
asodahs-128	225	1	open	open	ADJ
asodahs-128	225	2	access	access	NOUN
asodahs-128	225	3	review	review	NOUN
asodahs-128	225	4	article	article	NOUN
asodahs-128	225	5	http://jddtonline.info/	http://jddtonline.info/	NOUN
asodahs-128	225	6	http://dx.doi.org/10.22270/ajdhs.v5i3.128	http://dx.doi.org/10.22270/ajdhs.v5i3.128	VERB
asodahs-128	225	7	https://crossmark.crossref.org/dialog/?doi=10.22270/ajdhs.v5i3.128&domain=pdf	https://crossmark.crossref.org/dialog/?doi=10.22270/ajdhs.v5i3.128&domain=pdf	PROPN
asodahs-128	225	8	https://orcid.org/0000-0002-4538-0161	https://orcid.org/0000-0002-4538-0161	PROPN
asodahs-128	225	9	emmanuel	emmanuel	PROPN
asodahs-128	225	10	ifeanyi	ifeanyi	PROPN
asodahs-128	225	11	obeagu	obeagu	PROPN
asodahs-128	225	12	asian	asian	PROPN
asodahs-128	225	13	journal	journal	PROPN
asodahs-128	225	14	of	of	ADP
asodahs-128	225	15	dental	dental	ADJ
asodahs-128	225	16	and	and	CCONJ
asodahs-128	225	17	health	health	NOUN
asodahs-128	225	18	sciences	science	NOUN
asodahs-128	225	19	.	.	PUNCT
asodahs-128	225	20	2025	2025	NUM
asodahs-128	225	21	;	;	PUNCT
asodahs-128	225	22	5(3):1	5(3):1	NUM
asodahs-128	225	23	-	-	SYM
asodahs-128	225	24	5	5	NUM
asodahs-128	225	25	[	[	X
asodahs-128	225	26	2	2	NUM
asodahs-128	225	27	]	]	PUNCT
asodahs-128	225	28	ajdhs.com	ajdhs.com	X
asodahs-128	225	29	understanding	understand	VERB
asodahs-128	225	30	nitrogen	nitrogen	NOUN
asodahs-128	225	31	balance	balance	NOUN
asodahs-128	225	32	nitrogen	nitrogen	NOUN
asodahs-128	225	33	balance	balance	NOUN
asodahs-128	225	34	is	be	AUX
asodahs-128	225	35	a	a	DET
asodahs-128	225	36	fundamental	fundamental	ADJ
asodahs-128	225	37	concept	concept	NOUN
asodahs-128	225	38	in	in	ADP
asodahs-128	225	39	clinical	clinical	ADJ
asodahs-128	225	40	nutrition	nutrition	NOUN
asodahs-128	225	41	and	and	CCONJ
asodahs-128	225	42	physiology	physiology	NOUN
asodahs-128	225	43	,	,	PUNCT
asodahs-128	225	44	serving	serve	VERB
asodahs-128	225	45	as	as	ADP
asodahs-128	225	46	a	a	DET
asodahs-128	225	47	marker	marker	NOUN
asodahs-128	225	48	of	of	ADP
asodahs-128	225	49	protein	protein	NOUN
asodahs-128	225	50	metabolism	metabolism	NOUN
asodahs-128	225	51	and	and	CCONJ
asodahs-128	225	52	overall	overall	ADJ
asodahs-128	225	53	nutritional	nutritional	ADJ
asodahs-128	225	54	status	status	NOUN
asodahs-128	225	55	.	.	PUNCT
asodahs-128	226	1	it	it	PRON
asodahs-128	226	2	represents	represent	VERB
asodahs-128	226	3	the	the	DET
asodahs-128	226	4	equilibrium	equilibrium	NOUN
asodahs-128	226	5	between	between	ADP
asodahs-128	226	6	nitrogen	nitrogen	NOUN
asodahs-128	226	7	intake	intake	NOUN
asodahs-128	226	8	—	—	PUNCT
asodahs-128	226	9	largely	largely	ADV
asodahs-128	226	10	derived	derive	VERB
asodahs-128	226	11	from	from	ADP
asodahs-128	226	12	dietary	dietary	ADJ
asodahs-128	226	13	proteins	protein	NOUN
asodahs-128	226	14	—	—	PUNCT
asodahs-128	226	15	and	and	CCONJ
asodahs-128	226	16	nitrogen	nitrogen	NOUN
asodahs-128	226	17	excretion	excretion	NOUN
asodahs-128	226	18	,	,	PUNCT
asodahs-128	226	19	which	which	PRON
asodahs-128	226	20	occurs	occur	VERB
asodahs-128	226	21	primarily	primarily	ADV
asodahs-128	226	22	through	through	ADP
asodahs-128	226	23	urine	urine	NOUN
asodahs-128	226	24	in	in	ADP
asodahs-128	226	25	the	the	DET
asodahs-128	226	26	form	form	NOUN
asodahs-128	226	27	of	of	ADP
asodahs-128	226	28	urea	urea	NOUN
asodahs-128	226	29	,	,	PUNCT
asodahs-128	226	30	but	but	CCONJ
asodahs-128	226	31	also	also	ADV
asodahs-128	226	32	through	through	ADP
asodahs-128	226	33	feces	fece	NOUN
asodahs-128	226	34	,	,	PUNCT
asodahs-128	226	35	sweat	sweat	NOUN
asodahs-128	226	36	,	,	PUNCT
asodahs-128	226	37	skin	skin	NOUN
asodahs-128	226	38	desquamation	desquamation	NOUN
asodahs-128	226	39	,	,	PUNCT
asodahs-128	226	40	and	and	CCONJ
asodahs-128	226	41	other	other	ADJ
asodahs-128	226	42	minor	minor	ADJ
asodahs-128	226	43	losses	loss	NOUN
asodahs-128	226	44	.	.	PUNCT
asodahs-128	227	1	a	a	DET
asodahs-128	227	2	positive	positive	ADJ
asodahs-128	227	3	nitrogen	nitrogen	NOUN
asodahs-128	227	4	balance	balance	NOUN
asodahs-128	227	5	indicates	indicate	VERB
asodahs-128	227	6	an	an	DET
asodahs-128	227	7	anabolic	anabolic	NOUN
asodahs-128	227	8	state	state	NOUN
asodahs-128	227	9	,	,	PUNCT
asodahs-128	227	10	where	where	SCONJ
asodahs-128	227	11	nitrogen	nitrogen	PROPN
asodahs-128	227	12	intake	intake	NOUN
asodahs-128	227	13	exceeds	exceed	VERB
asodahs-128	227	14	loss	loss	NOUN
asodahs-128	227	15	,	,	PUNCT
asodahs-128	227	16	supporting	support	VERB
asodahs-128	227	17	growth	growth	NOUN
asodahs-128	227	18	,	,	PUNCT
asodahs-128	227	19	tissue	tissue	NOUN
asodahs-128	227	20	repair	repair	NOUN
asodahs-128	227	21	,	,	PUNCT
asodahs-128	227	22	and	and	CCONJ
asodahs-128	227	23	recovery	recovery	NOUN
asodahs-128	227	24	.	.	PUNCT
asodahs-128	228	1	in	in	ADP
asodahs-128	228	2	contrast	contrast	NOUN
asodahs-128	228	3	,	,	PUNCT
asodahs-128	228	4	a	a	DET
asodahs-128	228	5	negative	negative	ADJ
asodahs-128	228	6	nitrogen	nitrogen	NOUN
asodahs-128	228	7	balance	balance	NOUN
asodahs-128	228	8	suggests	suggest	VERB
asodahs-128	228	9	a	a	DET
asodahs-128	228	10	catabolic	catabolic	ADJ
asodahs-128	228	11	state	state	NOUN
asodahs-128	228	12	,	,	PUNCT
asodahs-128	228	13	where	where	SCONJ
asodahs-128	228	14	nitrogen	nitrogen	NOUN
asodahs-128	228	15	losses	loss	NOUN
asodahs-128	228	16	exceed	exceed	VERB
asodahs-128	228	17	intake	intake	NOUN
asodahs-128	228	18	,	,	PUNCT
asodahs-128	228	19	reflecting	reflect	VERB
asodahs-128	228	20	protein	protein	NOUN
asodahs-128	228	21	degradation	degradation	NOUN
asodahs-128	228	22	and	and	CCONJ
asodahs-128	228	23	inadequate	inadequate	ADJ
asodahs-128	228	24	nutritional	nutritional	ADJ
asodahs-128	228	25	support	support	NOUN
asodahs-128	228	26	16	16	NUM
asodahs-128	228	27	.	.	PUNCT
asodahs-128	229	1	in	in	ADP
asodahs-128	229	2	healthy	healthy	ADJ
asodahs-128	229	3	individuals	individual	NOUN
asodahs-128	229	4	,	,	PUNCT
asodahs-128	229	5	nitrogen	nitrogen	NOUN
asodahs-128	229	6	balance	balance	NOUN
asodahs-128	229	7	fluctuates	fluctuate	NOUN
asodahs-128	229	8	depending	depend	VERB
asodahs-128	229	9	on	on	ADP
asodahs-128	229	10	physiological	physiological	ADJ
asodahs-128	229	11	demands	demand	NOUN
asodahs-128	229	12	such	such	ADJ
asodahs-128	229	13	as	as	ADP
asodahs-128	229	14	growth	growth	NOUN
asodahs-128	229	15	(	(	PUNCT
asodahs-128	229	16	e.g.	e.g.	ADV
asodahs-128	229	17	,	,	PUNCT
asodahs-128	229	18	childhood	childhood	NOUN
asodahs-128	229	19	,	,	PUNCT
asodahs-128	229	20	adolescence	adolescence	NOUN
asodahs-128	229	21	)	)	PUNCT
asodahs-128	229	22	,	,	PUNCT
asodahs-128	229	23	pregnancy	pregnancy	NOUN
asodahs-128	229	24	,	,	PUNCT
asodahs-128	229	25	illness	illness	NOUN
asodahs-128	229	26	,	,	PUNCT
asodahs-128	229	27	or	or	CCONJ
asodahs-128	229	28	post	post	ADJ
asodahs-128	229	29	-	-	ADJ
asodahs-128	229	30	surgical	surgical	ADJ
asodahs-128	229	31	recovery	recovery	NOUN
asodahs-128	229	32	.	.	PUNCT
asodahs-128	230	1	the	the	DET
asodahs-128	230	2	body	body	NOUN
asodahs-128	230	3	requires	require	VERB
asodahs-128	230	4	a	a	DET
asodahs-128	230	5	constant	constant	ADJ
asodahs-128	230	6	supply	supply	NOUN
asodahs-128	230	7	of	of	ADP
asodahs-128	230	8	amino	amino	ADJ
asodahs-128	230	9	acids	acid	NOUN
asodahs-128	230	10	not	not	PART
asodahs-128	230	11	only	only	ADV
asodahs-128	230	12	for	for	ADP
asodahs-128	230	13	structural	structural	ADJ
asodahs-128	230	14	proteins	protein	NOUN
asodahs-128	230	15	but	but	CCONJ
asodahs-128	230	16	also	also	ADV
asodahs-128	230	17	for	for	ADP
asodahs-128	230	18	enzymes	enzyme	NOUN
asodahs-128	230	19	,	,	PUNCT
asodahs-128	230	20	hormones	hormone	NOUN
asodahs-128	230	21	,	,	PUNCT
asodahs-128	230	22	immunoglobulins	immunoglobulin	NOUN
asodahs-128	230	23	,	,	PUNCT
asodahs-128	230	24	and	and	CCONJ
asodahs-128	230	25	hemoglobin	hemoglobin	NOUN
asodahs-128	230	26	.	.	PUNCT
asodahs-128	231	1	when	when	SCONJ
asodahs-128	231	2	dietary	dietary	ADJ
asodahs-128	231	3	protein	protein	NOUN
asodahs-128	231	4	intake	intake	NOUN
asodahs-128	231	5	is	be	AUX
asodahs-128	231	6	insufficient	insufficient	ADJ
asodahs-128	231	7	or	or	CCONJ
asodahs-128	231	8	when	when	SCONJ
asodahs-128	231	9	metabolic	metabolic	NOUN
asodahs-128	231	10	demands	demand	NOUN
asodahs-128	231	11	are	be	AUX
asodahs-128	231	12	increased	increase	VERB
asodahs-128	231	13	—	—	PUNCT
asodahs-128	231	14	as	as	SCONJ
asodahs-128	231	15	seen	see	VERB
asodahs-128	231	16	in	in	ADP
asodahs-128	231	17	chronic	chronic	ADJ
asodahs-128	231	18	diseases	disease	NOUN
asodahs-128	231	19	like	like	ADP
asodahs-128	231	20	sickle	sickle	NOUN
asodahs-128	231	21	cell	cell	NOUN
asodahs-128	231	22	disease	disease	NOUN
asodahs-128	231	23	—	—	PUNCT
asodahs-128	231	24	the	the	DET
asodahs-128	231	25	body	body	NOUN
asodahs-128	231	26	begins	begin	VERB
asodahs-128	231	27	to	to	PART
asodahs-128	231	28	catabolize	catabolize	VERB
asodahs-128	231	29	its	its	PRON
asodahs-128	231	30	own	own	ADJ
asodahs-128	231	31	proteins	protein	NOUN
asodahs-128	231	32	,	,	PUNCT
asodahs-128	231	33	leading	lead	VERB
asodahs-128	231	34	to	to	ADP
asodahs-128	231	35	muscle	muscle	NOUN
asodahs-128	231	36	wasting	wasting	NOUN
asodahs-128	231	37	,	,	PUNCT
asodahs-128	231	38	immunosuppression	immunosuppression	NOUN
asodahs-128	231	39	,	,	PUNCT
asodahs-128	231	40	and	and	CCONJ
asodahs-128	231	41	impaired	impaired	ADJ
asodahs-128	231	42	erythropoiesis	erythropoiesis	NOUN
asodahs-128	231	43	17	17	NUM
asodahs-128	231	44	.	.	PUNCT
asodahs-128	232	1	measurement	measurement	NOUN
asodahs-128	232	2	of	of	ADP
asodahs-128	232	3	nitrogen	nitrogen	NOUN
asodahs-128	232	4	balance	balance	NOUN
asodahs-128	232	5	is	be	AUX
asodahs-128	232	6	typically	typically	ADV
asodahs-128	232	7	performed	perform	VERB
asodahs-128	232	8	through	through	ADP
asodahs-128	232	9	dietary	dietary	ADJ
asodahs-128	232	10	assessment	assessment	NOUN
asodahs-128	232	11	and	and	CCONJ
asodahs-128	232	12	analysis	analysis	NOUN
asodahs-128	232	13	of	of	ADP
asodahs-128	232	14	nitrogen	nitrogen	NOUN
asodahs-128	232	15	excretion	excretion	NOUN
asodahs-128	232	16	,	,	PUNCT
asodahs-128	232	17	most	most	ADV
asodahs-128	232	18	commonly	commonly	ADV
asodahs-128	232	19	via	via	ADP
asodahs-128	232	20	24	24	NUM
asodahs-128	232	21	-	-	PUNCT
asodahs-128	232	22	hour	hour	NOUN
asodahs-128	232	23	urinary	urinary	ADJ
asodahs-128	232	24	urea	urea	NOUN
asodahs-128	232	25	nitrogen	nitrogen	NOUN
asodahs-128	232	26	(	(	PUNCT
asodahs-128	232	27	uun	uun	PROPN
asodahs-128	232	28	)	)	PUNCT
asodahs-128	232	29	.	.	PUNCT
asodahs-128	233	1	the	the	DET
asodahs-128	233	2	calculation	calculation	NOUN
asodahs-128	233	3	takes	take	VERB
asodahs-128	233	4	into	into	ADP
asodahs-128	233	5	account	account	NOUN
asodahs-128	233	6	estimated	estimate	VERB
asodahs-128	233	7	non	non	ADJ
asodahs-128	233	8	-	-	ADJ
asodahs-128	233	9	urinary	urinary	ADJ
asodahs-128	233	10	nitrogen	nitrogen	NOUN
asodahs-128	233	11	losses	loss	NOUN
asodahs-128	233	12	and	and	CCONJ
asodahs-128	233	13	helps	help	VERB
asodahs-128	233	14	clinicians	clinician	NOUN
asodahs-128	233	15	evaluate	evaluate	VERB
asodahs-128	233	16	whether	whether	SCONJ
asodahs-128	233	17	a	a	DET
asodahs-128	233	18	patient	patient	NOUN
asodahs-128	233	19	is	be	AUX
asodahs-128	233	20	receiving	receive	VERB
asodahs-128	233	21	adequate	adequate	ADJ
asodahs-128	233	22	protein	protein	NOUN
asodahs-128	233	23	.	.	PUNCT
asodahs-128	234	1	however	however	ADV
asodahs-128	234	2	,	,	PUNCT
asodahs-128	234	3	in	in	ADP
asodahs-128	234	4	settings	setting	NOUN
asodahs-128	234	5	like	like	ADP
asodahs-128	234	6	scd	scd	NOUN
asodahs-128	234	7	,	,	PUNCT
asodahs-128	234	8	where	where	SCONJ
asodahs-128	234	9	inflammation	inflammation	NOUN
asodahs-128	234	10	and	and	CCONJ
asodahs-128	234	11	oxidative	oxidative	ADJ
asodahs-128	234	12	stress	stress	NOUN
asodahs-128	234	13	alter	alter	NOUN
asodahs-128	234	14	metabolism	metabolism	NOUN
asodahs-128	234	15	,	,	PUNCT
asodahs-128	234	16	interpreting	interpret	VERB
asodahs-128	234	17	nitrogen	nitrogen	NOUN
asodahs-128	234	18	balance	balance	NOUN
asodahs-128	234	19	becomes	become	VERB
asodahs-128	234	20	more	more	ADV
asodahs-128	234	21	complex	complex	ADJ
asodahs-128	234	22	.	.	PUNCT
asodahs-128	235	1	it	it	PRON
asodahs-128	235	2	is	be	AUX
asodahs-128	235	3	crucial	crucial	ADJ
asodahs-128	235	4	to	to	PART
asodahs-128	235	5	consider	consider	VERB
asodahs-128	235	6	the	the	DET
asodahs-128	235	7	disease	disease	NOUN
asodahs-128	235	8	-	-	PUNCT
asodahs-128	235	9	specific	specific	ADJ
asodahs-128	235	10	context	context	NOUN
asodahs-128	235	11	,	,	PUNCT
asodahs-128	235	12	as	as	SCONJ
asodahs-128	235	13	scd	scd	NOUN
asodahs-128	235	14	patients	patient	NOUN
asodahs-128	235	15	may	may	AUX
asodahs-128	235	16	exhibit	exhibit	VERB
asodahs-128	235	17	elevated	elevated	ADJ
asodahs-128	235	18	basal	basal	ADJ
asodahs-128	235	19	metabolic	metabolic	NOUN
asodahs-128	235	20	rates	rate	NOUN
asodahs-128	235	21	and	and	CCONJ
asodahs-128	235	22	protein	protein	NOUN
asodahs-128	235	23	turnover	turnover	NOUN
asodahs-128	235	24	even	even	ADV
asodahs-128	235	25	in	in	ADP
asodahs-128	235	26	clinically	clinically	ADV
asodahs-128	235	27	stable	stable	ADJ
asodahs-128	235	28	states	state	NOUN
asodahs-128	235	29	,	,	PUNCT
asodahs-128	235	30	thereby	thereby	ADV
asodahs-128	235	31	necessitating	necessitate	VERB
asodahs-128	235	32	higher	high	ADJ
asodahs-128	235	33	protein	protein	NOUN
asodahs-128	235	34	intake	intake	NOUN
asodahs-128	235	35	to	to	PART
asodahs-128	235	36	achieve	achieve	VERB
asodahs-128	235	37	nitrogen	nitrogen	NOUN
asodahs-128	235	38	equilibrium	equilibrium	NOUN
asodahs-128	235	39	18	18	NUM
asodahs-128	235	40	.	.	PUNCT
asodahs-128	236	1	in	in	ADP
asodahs-128	236	2	scd	scd	PROPN
asodahs-128	236	3	,	,	PUNCT
asodahs-128	236	4	maintaining	maintain	VERB
asodahs-128	236	5	nitrogen	nitrogen	NOUN
asodahs-128	236	6	balance	balance	NOUN
asodahs-128	236	7	is	be	AUX
asodahs-128	236	8	particularly	particularly	ADV
asodahs-128	236	9	challenging	challenging	ADJ
asodahs-128	236	10	due	due	ADJ
asodahs-128	236	11	to	to	ADP
asodahs-128	236	12	persistent	persistent	ADJ
asodahs-128	236	13	hemolysis	hemolysis	NOUN
asodahs-128	236	14	,	,	PUNCT
asodahs-128	236	15	increased	increase	VERB
asodahs-128	236	16	erythropoietic	erythropoietic	ADJ
asodahs-128	236	17	activity	activity	NOUN
asodahs-128	236	18	,	,	PUNCT
asodahs-128	236	19	and	and	CCONJ
asodahs-128	236	20	frequent	frequent	ADJ
asodahs-128	236	21	inflammatory	inflammatory	ADJ
asodahs-128	236	22	episodes	episode	NOUN
asodahs-128	236	23	.	.	PUNCT
asodahs-128	237	1	each	each	PRON
asodahs-128	237	2	of	of	ADP
asodahs-128	237	3	these	these	DET
asodahs-128	237	4	processes	process	NOUN
asodahs-128	237	5	imposes	impose	VERB
asodahs-128	237	6	a	a	DET
asodahs-128	237	7	substantial	substantial	ADJ
asodahs-128	237	8	demand	demand	NOUN
asodahs-128	237	9	on	on	ADP
asodahs-128	237	10	amino	amino	NOUN
asodahs-128	237	11	acid	acid	NOUN
asodahs-128	237	12	pools	pool	NOUN
asodahs-128	237	13	,	,	PUNCT
asodahs-128	237	14	making	make	VERB
asodahs-128	237	15	protein	protein	NOUN
asodahs-128	237	16	sufficiency	sufficiency	NOUN
asodahs-128	237	17	a	a	DET
asodahs-128	237	18	prerequisite	prerequisite	NOUN
asodahs-128	237	19	for	for	ADP
asodahs-128	237	20	adequate	adequate	ADJ
asodahs-128	237	21	hematological	hematological	ADJ
asodahs-128	237	22	function	function	NOUN
asodahs-128	237	23	.	.	PUNCT
asodahs-128	238	1	furthermore	furthermore	ADV
asodahs-128	238	2	,	,	PUNCT
asodahs-128	238	3	nitrogen	nitrogen	NOUN
asodahs-128	238	4	balance	balance	NOUN
asodahs-128	238	5	is	be	AUX
asodahs-128	238	6	intimately	intimately	ADV
asodahs-128	238	7	linked	link	VERB
asodahs-128	238	8	to	to	ADP
asodahs-128	238	9	overall	overall	ADJ
asodahs-128	238	10	clinical	clinical	ADJ
asodahs-128	238	11	outcomes	outcome	NOUN
asodahs-128	238	12	in	in	ADP
asodahs-128	238	13	scd	scd	PROPN
asodahs-128	238	14	—	—	PUNCT
asodahs-128	238	15	negative	negative	ADJ
asodahs-128	238	16	nitrogen	nitrogen	NOUN
asodahs-128	238	17	states	state	NOUN
asodahs-128	238	18	are	be	AUX
asodahs-128	238	19	associated	associate	VERB
asodahs-128	238	20	with	with	ADP
asodahs-128	238	21	increased	increase	VERB
asodahs-128	238	22	fatigue	fatigue	NOUN
asodahs-128	238	23	,	,	PUNCT
asodahs-128	238	24	reduced	reduce	VERB
asodahs-128	238	25	hemoglobin	hemoglobin	NOUN
asodahs-128	238	26	levels	level	NOUN
asodahs-128	238	27	,	,	PUNCT
asodahs-128	238	28	higher	high	ADJ
asodahs-128	238	29	susceptibility	susceptibility	NOUN
asodahs-128	238	30	to	to	ADP
asodahs-128	238	31	infections	infection	NOUN
asodahs-128	238	32	,	,	PUNCT
asodahs-128	238	33	and	and	CCONJ
asodahs-128	238	34	longer	long	ADJ
asodahs-128	238	35	recovery	recovery	NOUN
asodahs-128	238	36	periods	period	NOUN
asodahs-128	238	37	from	from	ADP
asodahs-128	238	38	vasoocclusive	vasoocclusive	ADJ
asodahs-128	238	39	crises	crisis	NOUN
asodahs-128	238	40	18	18	NUM
asodahs-128	238	41	.	.	PUNCT
asodahs-128	239	1	nitrogen	nitrogen	NOUN
asodahs-128	239	2	metabolism	metabolism	NOUN
asodahs-128	239	3	in	in	ADP
asodahs-128	239	4	sickle	sickle	NOUN
asodahs-128	239	5	cell	cell	NOUN
asodahs-128	239	6	disease	disease	NOUN
asodahs-128	239	7	nitrogen	nitrogen	NOUN
asodahs-128	239	8	metabolism	metabolism	NOUN
asodahs-128	239	9	plays	play	VERB
asodahs-128	239	10	a	a	DET
asodahs-128	239	11	pivotal	pivotal	ADJ
asodahs-128	239	12	role	role	NOUN
asodahs-128	239	13	in	in	ADP
asodahs-128	239	14	maintaining	maintain	VERB
asodahs-128	239	15	physiological	physiological	ADJ
asodahs-128	239	16	homeostasis	homeostasis	NOUN
asodahs-128	239	17	,	,	PUNCT
asodahs-128	239	18	particularly	particularly	ADV
asodahs-128	239	19	in	in	ADP
asodahs-128	239	20	conditions	condition	NOUN
asodahs-128	239	21	marked	mark	VERB
asodahs-128	239	22	by	by	ADP
asodahs-128	239	23	chronic	chronic	ADJ
asodahs-128	239	24	inflammation	inflammation	NOUN
asodahs-128	239	25	,	,	PUNCT
asodahs-128	239	26	increased	increase	VERB
asodahs-128	239	27	cellular	cellular	ADJ
asodahs-128	239	28	turnover	turnover	NOUN
asodahs-128	239	29	,	,	PUNCT
asodahs-128	239	30	and	and	CCONJ
asodahs-128	239	31	heightened	heighten	VERB
asodahs-128	239	32	metabolic	metabolic	NOUN
asodahs-128	239	33	demand	demand	NOUN
asodahs-128	239	34	—	—	PUNCT
asodahs-128	239	35	hallmarks	hallmark	NOUN
asodahs-128	239	36	of	of	ADP
asodahs-128	239	37	sickle	sickle	NOUN
asodahs-128	239	38	cell	cell	NOUN
asodahs-128	239	39	disease	disease	NOUN
asodahs-128	239	40	(	(	PUNCT
asodahs-128	239	41	scd	scd	NOUN
asodahs-128	239	42	)	)	PUNCT
asodahs-128	239	43	.	.	PUNCT
asodahs-128	240	1	in	in	ADP
asodahs-128	240	2	individuals	individual	NOUN
asodahs-128	240	3	with	with	ADP
asodahs-128	240	4	scd	scd	PROPN
asodahs-128	240	5	,	,	PUNCT
asodahs-128	240	6	the	the	DET
asodahs-128	240	7	pathophysiology	pathophysiology	NOUN
asodahs-128	240	8	of	of	ADP
asodahs-128	240	9	the	the	DET
asodahs-128	240	10	disease	disease	NOUN
asodahs-128	240	11	imposes	impose	VERB
asodahs-128	240	12	a	a	DET
asodahs-128	240	13	substantial	substantial	ADJ
asodahs-128	240	14	burden	burden	NOUN
asodahs-128	240	15	on	on	ADP
asodahs-128	240	16	protein	protein	NOUN
asodahs-128	240	17	metabolism	metabolism	NOUN
asodahs-128	240	18	due	due	ADP
asodahs-128	240	19	to	to	ADP
asodahs-128	240	20	the	the	DET
asodahs-128	240	21	continuous	continuous	ADJ
asodahs-128	240	22	need	need	NOUN
asodahs-128	240	23	for	for	ADP
asodahs-128	240	24	erythrocyte	erythrocyte	NOUN
asodahs-128	240	25	regeneration	regeneration	NOUN
asodahs-128	240	26	,	,	PUNCT
asodahs-128	240	27	tissue	tissue	NOUN
asodahs-128	240	28	repair	repair	NOUN
asodahs-128	240	29	,	,	PUNCT
asodahs-128	240	30	and	and	CCONJ
asodahs-128	240	31	immune	immune	ADJ
asodahs-128	240	32	function	function	NOUN
asodahs-128	240	33	support	support	NOUN
asodahs-128	240	34	.	.	PUNCT
asodahs-128	241	1	these	these	DET
asodahs-128	241	2	processes	process	VERB
asodahs-128	241	3	necessitate	necessitate	ADJ
asodahs-128	241	4	a	a	DET
asodahs-128	241	5	constant	constant	ADJ
asodahs-128	241	6	and	and	CCONJ
asodahs-128	241	7	elevated	elevated	ADJ
asodahs-128	241	8	supply	supply	NOUN
asodahs-128	241	9	of	of	ADP
asodahs-128	241	10	amino	amino	ADJ
asodahs-128	241	11	acids	acid	NOUN
asodahs-128	241	12	,	,	PUNCT
asodahs-128	241	13	making	make	VERB
asodahs-128	241	14	nitrogen	nitrogen	NOUN
asodahs-128	241	15	metabolism	metabolism	NOUN
asodahs-128	241	16	a	a	DET
asodahs-128	241	17	critical	critical	ADJ
asodahs-128	241	18	determinant	determinant	NOUN
asodahs-128	241	19	of	of	ADP
asodahs-128	241	20	health	health	NOUN
asodahs-128	241	21	outcomes	outcome	NOUN
asodahs-128	241	22	in	in	ADP
asodahs-128	241	23	this	this	DET
asodahs-128	241	24	population	population	NOUN
asodahs-128	241	25	19	19	NUM
asodahs-128	241	26	-	-	SYM
asodahs-128	241	27	20	20	NUM
asodahs-128	241	28	.	.	PUNCT
asodahs-128	242	1	one	one	NUM
asodahs-128	242	2	of	of	ADP
asodahs-128	242	3	the	the	DET
asodahs-128	242	4	primary	primary	ADJ
asodahs-128	242	5	contributors	contributor	NOUN
asodahs-128	242	6	to	to	PART
asodahs-128	242	7	altered	altered	VERB
asodahs-128	242	8	nitrogen	nitrogen	NOUN
asodahs-128	242	9	metabolism	metabolism	NOUN
asodahs-128	242	10	in	in	ADP
asodahs-128	242	11	scd	scd	PROPN
asodahs-128	242	12	is	be	AUX
asodahs-128	242	13	the	the	DET
asodahs-128	242	14	state	state	NOUN
asodahs-128	242	15	of	of	ADP
asodahs-128	242	16	chronic	chronic	ADJ
asodahs-128	242	17	hemolysis	hemolysis	NOUN
asodahs-128	242	18	.	.	PUNCT
asodahs-128	243	1	hemolysis	hemolysis	NOUN
asodahs-128	243	2	not	not	PART
asodahs-128	243	3	only	only	ADV
asodahs-128	243	4	leads	lead	VERB
asodahs-128	243	5	to	to	ADP
asodahs-128	243	6	anemia	anemia	NOUN
asodahs-128	243	7	and	and	CCONJ
asodahs-128	243	8	reduced	reduce	VERB
asodahs-128	243	9	oxygen	oxygen	NOUN
asodahs-128	243	10	-	-	PUNCT
asodahs-128	243	11	carrying	carry	VERB
asodahs-128	243	12	capacity	capacity	NOUN
asodahs-128	243	13	but	but	CCONJ
asodahs-128	243	14	also	also	ADV
asodahs-128	243	15	accelerates	accelerate	VERB
asodahs-128	243	16	the	the	DET
asodahs-128	243	17	turnover	turnover	NOUN
asodahs-128	243	18	of	of	ADP
asodahs-128	243	19	erythrocytes	erythrocyte	NOUN
asodahs-128	243	20	,	,	PUNCT
asodahs-128	243	21	thereby	thereby	ADV
asodahs-128	243	22	increasing	increase	VERB
asodahs-128	243	23	the	the	DET
asodahs-128	243	24	demand	demand	NOUN
asodahs-128	243	25	for	for	ADP
asodahs-128	243	26	protein	protein	NOUN
asodahs-128	243	27	synthesis	synthesis	NOUN
asodahs-128	243	28	to	to	PART
asodahs-128	243	29	replenish	replenish	VERB
asodahs-128	243	30	red	red	ADJ
asodahs-128	243	31	blood	blood	NOUN
asodahs-128	243	32	cells	cell	NOUN
asodahs-128	243	33	.	.	PUNCT
asodahs-128	244	1	this	this	DET
asodahs-128	244	2	continuous	continuous	ADJ
asodahs-128	244	3	erythropoietic	erythropoietic	ADJ
asodahs-128	244	4	drive	drive	NOUN
asodahs-128	244	5	consumes	consume	VERB
asodahs-128	244	6	large	large	ADJ
asodahs-128	244	7	amounts	amount	NOUN
asodahs-128	244	8	of	of	ADP
asodahs-128	244	9	nitrogen	nitrogen	NOUN
asodahs-128	244	10	in	in	ADP
asodahs-128	244	11	the	the	DET
asodahs-128	244	12	form	form	NOUN
asodahs-128	244	13	of	of	ADP
asodahs-128	244	14	amino	amino	ADJ
asodahs-128	244	15	acids	acid	NOUN
asodahs-128	244	16	necessary	necessary	ADJ
asodahs-128	244	17	for	for	ADP
asodahs-128	244	18	hemoglobin	hemoglobin	NOUN
asodahs-128	244	19	and	and	CCONJ
asodahs-128	244	20	cellular	cellular	ADJ
asodahs-128	244	21	component	component	NOUN
asodahs-128	244	22	production	production	NOUN
asodahs-128	244	23	.	.	PUNCT
asodahs-128	245	1	inadequate	inadequate	ADJ
asodahs-128	245	2	dietary	dietary	ADJ
asodahs-128	245	3	protein	protein	NOUN
asodahs-128	245	4	or	or	CCONJ
asodahs-128	245	5	inefficient	inefficient	ADJ
asodahs-128	245	6	utilization	utilization	NOUN
asodahs-128	245	7	of	of	ADP
asodahs-128	245	8	nitrogen	nitrogen	NOUN
asodahs-128	245	9	can	can	AUX
asodahs-128	245	10	thus	thus	ADV
asodahs-128	245	11	lead	lead	VERB
asodahs-128	245	12	to	to	ADP
asodahs-128	245	13	a	a	DET
asodahs-128	245	14	deficit	deficit	NOUN
asodahs-128	245	15	,	,	PUNCT
asodahs-128	245	16	resulting	result	VERB
asodahs-128	245	17	in	in	ADP
asodahs-128	245	18	negative	negative	ADJ
asodahs-128	245	19	nitrogen	nitrogen	NOUN
asodahs-128	245	20	balance	balance	NOUN
asodahs-128	245	21	and	and	CCONJ
asodahs-128	245	22	its	its	PRON
asodahs-128	245	23	attendant	attendant	ADJ
asodahs-128	245	24	complications	complication	NOUN
asodahs-128	245	25	21	21	NUM
asodahs-128	245	26	.	.	PUNCT
asodahs-128	246	1	in	in	ADP
asodahs-128	246	2	addition	addition	NOUN
asodahs-128	246	3	to	to	ADP
asodahs-128	246	4	hemolysis	hemolysis	NOUN
asodahs-128	246	5	,	,	PUNCT
asodahs-128	246	6	recurrent	recurrent	ADJ
asodahs-128	246	7	infections	infection	NOUN
asodahs-128	246	8	and	and	CCONJ
asodahs-128	246	9	vasoocclusive	vasoocclusive	ADJ
asodahs-128	246	10	crises	crisis	NOUN
asodahs-128	246	11	in	in	ADP
asodahs-128	246	12	scd	scd	PROPN
asodahs-128	246	13	further	far	ADV
asodahs-128	246	14	compound	compound	NOUN
asodahs-128	246	15	nitrogen	nitrogen	NOUN
asodahs-128	246	16	losses	loss	NOUN
asodahs-128	246	17	through	through	ADP
asodahs-128	246	18	systemic	systemic	ADJ
asodahs-128	246	19	inflammation	inflammation	NOUN
asodahs-128	246	20	and	and	CCONJ
asodahs-128	246	21	catabolic	catabolic	ADJ
asodahs-128	246	22	stress	stress	NOUN
asodahs-128	246	23	.	.	PUNCT
asodahs-128	247	1	during	during	ADP
asodahs-128	247	2	these	these	DET
asodahs-128	247	3	episodes	episode	NOUN
asodahs-128	247	4	,	,	PUNCT
asodahs-128	247	5	pro	pro	ADJ
asodahs-128	247	6	-	-	ADJ
asodahs-128	247	7	inflammatory	inflammatory	ADJ
asodahs-128	247	8	cytokines	cytokine	NOUN
asodahs-128	247	9	such	such	ADJ
asodahs-128	247	10	as	as	ADP
asodahs-128	247	11	interleukin-6	interleukin-6	PROPN
asodahs-128	247	12	(	(	PUNCT
asodahs-128	247	13	il-6	il-6	NUM
asodahs-128	247	14	)	)	PUNCT
asodahs-128	247	15	and	and	CCONJ
asodahs-128	247	16	tumor	tumor	NOUN
asodahs-128	247	17	necrosis	necrosis	NOUN
asodahs-128	247	18	factor	factor	NOUN
asodahs-128	247	19	-	-	PUNCT
asodahs-128	247	20	alpha	alpha	NOUN
asodahs-128	247	21	(	(	PUNCT
asodahs-128	247	22	tnf	tnf	PROPN
asodahs-128	247	23	-	-	PUNCT
asodahs-128	247	24	α	α	NOUN
asodahs-128	247	25	)	)	PUNCT
asodahs-128	247	26	stimulate	stimulate	VERB
asodahs-128	247	27	protein	protein	NOUN
asodahs-128	247	28	breakdown	breakdown	NOUN
asodahs-128	247	29	in	in	ADP
asodahs-128	247	30	muscle	muscle	NOUN
asodahs-128	247	31	tissue	tissue	NOUN
asodahs-128	247	32	,	,	PUNCT
asodahs-128	247	33	divert	divert	VERB
asodahs-128	247	34	amino	amino	ADJ
asodahs-128	247	35	acids	acid	NOUN
asodahs-128	247	36	away	away	ADV
asodahs-128	247	37	from	from	ADP
asodahs-128	247	38	constructive	constructive	ADJ
asodahs-128	247	39	processes	process	NOUN
asodahs-128	247	40	like	like	ADP
asodahs-128	247	41	hematopoiesis	hematopoiesis	NOUN
asodahs-128	247	42	,	,	PUNCT
asodahs-128	247	43	and	and	CCONJ
asodahs-128	247	44	increase	increase	VERB
asodahs-128	247	45	urinary	urinary	ADJ
asodahs-128	247	46	nitrogen	nitrogen	NOUN
asodahs-128	247	47	excretion	excretion	NOUN
asodahs-128	247	48	.	.	PUNCT
asodahs-128	248	1	fever	fever	NOUN
asodahs-128	248	2	,	,	PUNCT
asodahs-128	248	3	tissue	tissue	NOUN
asodahs-128	248	4	damage	damage	NOUN
asodahs-128	248	5	,	,	PUNCT
asodahs-128	248	6	and	and	CCONJ
asodahs-128	248	7	organ	organ	NOUN
asodahs-128	248	8	dysfunction	dysfunction	NOUN
asodahs-128	248	9	may	may	AUX
asodahs-128	248	10	also	also	ADV
asodahs-128	248	11	impair	impair	VERB
asodahs-128	248	12	nutrient	nutrient	NOUN
asodahs-128	248	13	absorption	absorption	NOUN
asodahs-128	248	14	and	and	CCONJ
asodahs-128	248	15	utilization	utilization	NOUN
asodahs-128	248	16	,	,	PUNCT
asodahs-128	248	17	making	make	VERB
asodahs-128	248	18	it	it	PRON
asodahs-128	248	19	more	more	ADV
asodahs-128	248	20	difficult	difficult	ADJ
asodahs-128	248	21	to	to	PART
asodahs-128	248	22	maintain	maintain	VERB
asodahs-128	248	23	a	a	DET
asodahs-128	248	24	favorable	favorable	ADJ
asodahs-128	248	25	nitrogen	nitrogen	NOUN
asodahs-128	248	26	status	status	NOUN
asodahs-128	248	27	22	22	NUM
asodahs-128	248	28	-	-	SYM
asodahs-128	248	29	23	23	NUM
asodahs-128	248	30	.	.	PUNCT
asodahs-128	249	1	the	the	DET
asodahs-128	249	2	metabolic	metabolic	NOUN
asodahs-128	249	3	adaptations	adaptation	NOUN
asodahs-128	249	4	observed	observe	VERB
asodahs-128	249	5	in	in	ADP
asodahs-128	249	6	scd	scd	PROPN
asodahs-128	249	7	,	,	PUNCT
asodahs-128	249	8	including	include	VERB
asodahs-128	249	9	elevated	elevated	ADJ
asodahs-128	249	10	resting	rest	VERB
asodahs-128	249	11	energy	energy	NOUN
asodahs-128	249	12	expenditure	expenditure	NOUN
asodahs-128	249	13	and	and	CCONJ
asodahs-128	249	14	increased	increase	VERB
asodahs-128	249	15	protein	protein	NOUN
asodahs-128	249	16	turnover	turnover	NOUN
asodahs-128	249	17	,	,	PUNCT
asodahs-128	249	18	also	also	ADV
asodahs-128	249	19	affect	affect	VERB
asodahs-128	249	20	nitrogen	nitrogen	NOUN
asodahs-128	249	21	utilization	utilization	NOUN
asodahs-128	249	22	.	.	PUNCT
asodahs-128	250	1	several	several	ADJ
asodahs-128	250	2	studies	study	NOUN
asodahs-128	250	3	have	have	AUX
asodahs-128	250	4	documented	document	VERB
asodahs-128	250	5	higher	high	ADJ
asodahs-128	250	6	caloric	caloric	NOUN
asodahs-128	250	7	and	and	CCONJ
asodahs-128	250	8	protein	protein	NOUN
asodahs-128	250	9	needs	need	VERB
asodahs-128	250	10	in	in	ADP
asodahs-128	250	11	children	child	NOUN
asodahs-128	250	12	and	and	CCONJ
asodahs-128	250	13	adults	adult	NOUN
asodahs-128	250	14	with	with	ADP
asodahs-128	250	15	scd	scd	NOUN
asodahs-128	250	16	compared	compare	VERB
asodahs-128	250	17	to	to	ADP
asodahs-128	250	18	healthy	healthy	ADJ
asodahs-128	250	19	controls	control	NOUN
asodahs-128	250	20	,	,	PUNCT
asodahs-128	250	21	even	even	ADV
asodahs-128	250	22	during	during	ADP
asodahs-128	250	23	periods	period	NOUN
asodahs-128	250	24	of	of	ADP
asodahs-128	250	25	clinical	clinical	ADJ
asodahs-128	250	26	stability	stability	NOUN
asodahs-128	250	27	.	.	PUNCT
asodahs-128	251	1	however	however	ADV
asodahs-128	251	2	,	,	PUNCT
asodahs-128	251	3	standard	standard	ADJ
asodahs-128	251	4	nutritional	nutritional	ADJ
asodahs-128	251	5	guidelines	guideline	NOUN
asodahs-128	251	6	often	often	ADV
asodahs-128	251	7	fail	fail	VERB
asodahs-128	251	8	to	to	PART
asodahs-128	251	9	reflect	reflect	VERB
asodahs-128	251	10	these	these	DET
asodahs-128	251	11	heightened	heighten	VERB
asodahs-128	251	12	requirements	requirement	NOUN
asodahs-128	251	13	,	,	PUNCT
asodahs-128	251	14	leading	lead	VERB
asodahs-128	251	15	to	to	ADP
asodahs-128	251	16	chronic	chronic	ADJ
asodahs-128	251	17	undernutrition	undernutrition	NOUN
asodahs-128	251	18	and	and	CCONJ
asodahs-128	251	19	suboptimal	suboptimal	ADJ
asodahs-128	251	20	nitrogen	nitrogen	NOUN
asodahs-128	251	21	retention	retention	NOUN
asodahs-128	251	22	.	.	PUNCT
asodahs-128	252	1	this	this	DET
asodahs-128	252	2	discrepancy	discrepancy	NOUN
asodahs-128	252	3	contributes	contribute	VERB
asodahs-128	252	4	to	to	ADP
asodahs-128	252	5	poor	poor	ADJ
asodahs-128	252	6	growth	growth	NOUN
asodahs-128	252	7	,	,	PUNCT
asodahs-128	252	8	delayed	delay	VERB
asodahs-128	252	9	puberty	puberty	NOUN
asodahs-128	252	10	,	,	PUNCT
asodahs-128	252	11	and	and	CCONJ
asodahs-128	252	12	reduced	reduce	VERB
asodahs-128	252	13	resilience	resilience	NOUN
asodahs-128	252	14	against	against	ADP
asodahs-128	252	15	oxidative	oxidative	ADJ
asodahs-128	252	16	and	and	CCONJ
asodahs-128	252	17	infectious	infectious	ADJ
asodahs-128	252	18	insults	insult	NOUN
asodahs-128	252	19	24	24	NUM
asodahs-128	252	20	-	-	SYM
asodahs-128	252	21	25	25	NUM
asodahs-128	252	22	from	from	ADP
asodahs-128	252	23	a	a	DET
asodahs-128	252	24	biochemical	biochemical	ADJ
asodahs-128	252	25	perspective	perspective	NOUN
asodahs-128	252	26	,	,	PUNCT
asodahs-128	252	27	disruptions	disruption	NOUN
asodahs-128	252	28	in	in	ADP
asodahs-128	252	29	nitrogen	nitrogen	NOUN
asodahs-128	252	30	metabolism	metabolism	NOUN
asodahs-128	252	31	in	in	ADP
asodahs-128	252	32	scd	scd	PROPN
asodahs-128	252	33	also	also	ADV
asodahs-128	252	34	affect	affect	VERB
asodahs-128	252	35	other	other	ADJ
asodahs-128	252	36	physiological	physiological	ADJ
asodahs-128	252	37	systems	system	NOUN
asodahs-128	252	38	,	,	PUNCT
asodahs-128	252	39	including	include	VERB
asodahs-128	252	40	the	the	DET
asodahs-128	252	41	urea	urea	NOUN
asodahs-128	252	42	cycle	cycle	NOUN
asodahs-128	252	43	,	,	PUNCT
asodahs-128	252	44	amino	amino	NOUN
asodahs-128	252	45	acid	acid	NOUN
asodahs-128	252	46	synthesis	synthesis	NOUN
asodahs-128	252	47	,	,	PUNCT
asodahs-128	252	48	and	and	CCONJ
asodahs-128	252	49	nitric	nitric	ADJ
asodahs-128	252	50	oxide	oxide	NOUN
asodahs-128	252	51	(	(	PUNCT
asodahs-128	252	52	no	no	NOUN
asodahs-128	252	53	)	)	PUNCT
asodahs-128	252	54	production	production	NOUN
asodahs-128	252	55	.	.	PUNCT
asodahs-128	252	56	arginine	arginine	NOUN
asodahs-128	252	57	,	,	PUNCT
asodahs-128	252	58	a	a	DET
asodahs-128	252	59	semi	semi	ADJ
asodahs-128	252	60	-	-	ADJ
asodahs-128	252	61	essential	essential	ADJ
asodahs-128	252	62	amino	amino	NOUN
asodahs-128	252	63	acid	acid	NOUN
asodahs-128	252	64	and	and	CCONJ
asodahs-128	252	65	a	a	DET
asodahs-128	252	66	key	key	ADJ
asodahs-128	252	67	component	component	NOUN
asodahs-128	252	68	of	of	ADP
asodahs-128	252	69	nitrogen	nitrogen	NOUN
asodahs-128	252	70	metabolism	metabolism	NOUN
asodahs-128	252	71	,	,	PUNCT
asodahs-128	252	72	is	be	AUX
asodahs-128	252	73	often	often	ADV
asodahs-128	252	74	depleted	deplete	VERB
asodahs-128	252	75	in	in	ADP
asodahs-128	252	76	scd	scd	NOUN
asodahs-128	252	77	due	due	ADP
asodahs-128	252	78	to	to	ADP
asodahs-128	252	79	increased	increase	VERB
asodahs-128	252	80	consumption	consumption	NOUN
asodahs-128	252	81	in	in	ADP
asodahs-128	252	82	hemolysis	hemolysis	NOUN
asodahs-128	252	83	and	and	CCONJ
asodahs-128	252	84	inflammation	inflammation	NOUN
asodahs-128	252	85	.	.	PUNCT
asodahs-128	253	1	arginine	arginine	NOUN
asodahs-128	253	2	deficiency	deficiency	NOUN
asodahs-128	253	3	can	can	AUX
asodahs-128	253	4	impair	impair	VERB
asodahs-128	253	5	no	no	DET
asodahs-128	253	6	synthesis	synthesis	NOUN
asodahs-128	253	7	,	,	PUNCT
asodahs-128	253	8	contributing	contribute	VERB
asodahs-128	253	9	to	to	ADP
asodahs-128	253	10	endothelial	endothelial	ADJ
asodahs-128	253	11	dysfunction	dysfunction	NOUN
asodahs-128	253	12	and	and	CCONJ
asodahs-128	253	13	worsening	worsen	VERB
asodahs-128	253	14	vaso	vaso	NOUN
asodahs-128	253	15	-	-	PUNCT
asodahs-128	253	16	occlusive	occlusive	ADJ
asodahs-128	253	17	phenomena	phenomenon	NOUN
asodahs-128	253	18	.	.	PUNCT
asodahs-128	254	1	these	these	DET
asodahs-128	254	2	intricate	intricate	ADJ
asodahs-128	254	3	interplays	interplay	NOUN
asodahs-128	254	4	highlight	highlight	VERB
asodahs-128	254	5	how	how	SCONJ
asodahs-128	254	6	nitrogen	nitrogen	NOUN
asodahs-128	254	7	metabolism	metabolism	NOUN
asodahs-128	254	8	extends	extend	VERB
asodahs-128	254	9	beyond	beyond	ADP
asodahs-128	254	10	nutritional	nutritional	ADJ
asodahs-128	254	11	status	status	NOUN
asodahs-128	254	12	,	,	PUNCT
asodahs-128	254	13	directly	directly	ADV
asodahs-128	254	14	influencing	influence	VERB
asodahs-128	254	15	vascular	vascular	ADJ
asodahs-128	254	16	tone	tone	NOUN
asodahs-128	254	17	and	and	CCONJ
asodahs-128	254	18	hematologic	hematologic	NOUN
asodahs-128	254	19	stability	stability	NOUN
asodahs-128	254	20	in	in	ADP
asodahs-128	254	21	scd	scd	PROPN
asodahs-128	254	22	26	26	NUM
asodahs-128	254	23	.	.	PUNCT
asodahs-128	255	1	hematological	hematological	ADJ
asodahs-128	255	2	implications	implication	NOUN
asodahs-128	255	3	of	of	ADP
asodahs-128	255	4	nitrogen	nitrogen	NOUN
asodahs-128	255	5	imbalance	imbalance	NOUN
asodahs-128	255	6	nitrogen	nitrogen	NOUN
asodahs-128	255	7	imbalance	imbalance	NOUN
asodahs-128	255	8	in	in	ADP
asodahs-128	255	9	individuals	individual	NOUN
asodahs-128	255	10	with	with	ADP
asodahs-128	255	11	sickle	sickle	NOUN
asodahs-128	255	12	cell	cell	NOUN
asodahs-128	255	13	disease	disease	NOUN
asodahs-128	255	14	(	(	PUNCT
asodahs-128	255	15	scd	scd	NOUN
asodahs-128	255	16	)	)	PUNCT
asodahs-128	255	17	is	be	AUX
asodahs-128	255	18	not	not	PART
asodahs-128	255	19	merely	merely	ADV
asodahs-128	255	20	a	a	DET
asodahs-128	255	21	nutritional	nutritional	ADJ
asodahs-128	255	22	concern	concern	NOUN
asodahs-128	255	23	;	;	PUNCT
asodahs-128	255	24	it	it	PRON
asodahs-128	255	25	has	have	VERB
asodahs-128	255	26	direct	direct	ADJ
asodahs-128	255	27	and	and	CCONJ
asodahs-128	255	28	far	far	ADV
asodahs-128	255	29	-	-	PUNCT
asodahs-128	255	30	reaching	reach	VERB
asodahs-128	255	31	hematological	hematological	ADJ
asodahs-128	255	32	implications	implication	NOUN
asodahs-128	255	33	.	.	PUNCT
asodahs-128	256	1	the	the	DET
asodahs-128	256	2	continuous	continuous	ADJ
asodahs-128	256	3	loss	loss	NOUN
asodahs-128	256	4	of	of	ADP
asodahs-128	256	5	nitrogen	nitrogen	NOUN
asodahs-128	256	6	,	,	PUNCT
asodahs-128	256	7	when	when	SCONJ
asodahs-128	256	8	not	not	PART
asodahs-128	256	9	matched	match	VERB
asodahs-128	256	10	by	by	ADP
asodahs-128	256	11	adequate	adequate	ADJ
asodahs-128	256	12	dietary	dietary	ADJ
asodahs-128	256	13	intake	intake	NOUN
asodahs-128	256	14	,	,	PUNCT
asodahs-128	256	15	disrupts	disrupt	VERB
asodahs-128	256	16	protein	protein	NOUN
asodahs-128	256	17	homeostasis	homeostasis	NOUN
asodahs-128	256	18	and	and	CCONJ
asodahs-128	256	19	undermines	undermine	VERB
asodahs-128	256	20	essential	essential	ADJ
asodahs-128	256	21	physiological	physiological	ADJ
asodahs-128	256	22	processes	process	NOUN
asodahs-128	256	23	emmanuel	emmanuel	PROPN
asodahs-128	256	24	ifeanyi	ifeanyi	PROPN
asodahs-128	256	25	obeagu	obeagu	PROPN
asodahs-128	256	26	asian	asian	PROPN
asodahs-128	256	27	journal	journal	PROPN
asodahs-128	256	28	of	of	ADP
asodahs-128	256	29	dental	dental	ADJ
asodahs-128	256	30	and	and	CCONJ
asodahs-128	256	31	health	health	NOUN
asodahs-128	256	32	sciences	science	NOUN
asodahs-128	256	33	.	.	PUNCT
asodahs-128	256	34	2025	2025	NUM
asodahs-128	256	35	;	;	PUNCT
asodahs-128	256	36	5(3):1	5(3):1	NUM
asodahs-128	256	37	-	-	SYM
asodahs-128	256	38	5	5	NUM
asodahs-128	256	39	[	[	X
asodahs-128	256	40	3	3	NUM
asodahs-128	256	41	]	]	PUNCT
asodahs-128	256	42	ajdhs.com	ajdhs.com	X
asodahs-128	256	43	involved	involve	VERB
asodahs-128	256	44	in	in	ADP
asodahs-128	256	45	hematopoiesis	hematopoiesis	NOUN
asodahs-128	256	46	.	.	PUNCT
asodahs-128	257	1	this	this	DET
asodahs-128	257	2	imbalance	imbalance	NOUN
asodahs-128	257	3	contributes	contribute	VERB
asodahs-128	257	4	significantly	significantly	ADV
asodahs-128	257	5	to	to	ADP
asodahs-128	257	6	the	the	DET
asodahs-128	257	7	severity	severity	NOUN
asodahs-128	257	8	of	of	ADP
asodahs-128	257	9	anemia	anemia	NOUN
asodahs-128	257	10	,	,	PUNCT
asodahs-128	257	11	immune	immune	ADJ
asodahs-128	257	12	dysfunction	dysfunction	NOUN
asodahs-128	257	13	,	,	PUNCT
asodahs-128	257	14	and	and	CCONJ
asodahs-128	257	15	delayed	delay	VERB
asodahs-128	257	16	recovery	recovery	NOUN
asodahs-128	257	17	from	from	ADP
asodahs-128	257	18	hematologic	hematologic	ADJ
asodahs-128	257	19	insults	insult	NOUN
asodahs-128	257	20	commonly	commonly	ADV
asodahs-128	257	21	encountered	encounter	VERB
asodahs-128	257	22	in	in	ADP
asodahs-128	257	23	scd	scd	PROPN
asodahs-128	257	24	20	20	NUM
asodahs-128	257	25	.	.	PUNCT
asodahs-128	258	1	hemoglobin	hemoglobin	NOUN
asodahs-128	258	2	synthesis	synthesis	NOUN
asodahs-128	258	3	is	be	AUX
asodahs-128	258	4	one	one	NUM
asodahs-128	258	5	of	of	ADP
asodahs-128	258	6	the	the	DET
asodahs-128	258	7	most	most	ADV
asodahs-128	258	8	nitrogen	nitrogen	NOUN
asodahs-128	258	9	-	-	PUNCT
asodahs-128	258	10	intensive	intensive	ADJ
asodahs-128	258	11	biological	biological	ADJ
asodahs-128	258	12	processes	process	NOUN
asodahs-128	258	13	.	.	PUNCT
asodahs-128	259	1	in	in	ADP
asodahs-128	259	2	scd	scd	PROPN
asodahs-128	259	3	,	,	PUNCT
asodahs-128	259	4	where	where	SCONJ
asodahs-128	259	5	erythrocyte	erythrocyte	NOUN
asodahs-128	259	6	lifespan	lifespan	NOUN
asodahs-128	259	7	is	be	AUX
asodahs-128	259	8	significantly	significantly	ADV
asodahs-128	259	9	shortened	shorten	VERB
asodahs-128	259	10	due	due	ADJ
asodahs-128	259	11	to	to	ADP
asodahs-128	259	12	chronic	chronic	ADJ
asodahs-128	259	13	hemolysis	hemolysis	NOUN
asodahs-128	259	14	,	,	PUNCT
asodahs-128	259	15	the	the	DET
asodahs-128	259	16	bone	bone	NOUN
asodahs-128	259	17	marrow	marrow	NOUN
asodahs-128	259	18	is	be	AUX
asodahs-128	259	19	under	under	ADP
asodahs-128	259	20	constant	constant	ADJ
asodahs-128	259	21	pressure	pressure	NOUN
asodahs-128	259	22	to	to	PART
asodahs-128	259	23	replenish	replenish	VERB
asodahs-128	259	24	red	red	ADJ
asodahs-128	259	25	blood	blood	NOUN
asodahs-128	259	26	cells	cell	NOUN
asodahs-128	259	27	.	.	PUNCT
asodahs-128	260	1	a	a	DET
asodahs-128	260	2	negative	negative	ADJ
asodahs-128	260	3	nitrogen	nitrogen	NOUN
asodahs-128	260	4	balance	balance	NOUN
asodahs-128	260	5	compromises	compromise	VERB
asodahs-128	260	6	the	the	DET
asodahs-128	260	7	availability	availability	NOUN
asodahs-128	260	8	of	of	ADP
asodahs-128	260	9	amino	amino	ADJ
asodahs-128	260	10	acids	acid	NOUN
asodahs-128	260	11	—	—	PUNCT
asodahs-128	260	12	particularly	particularly	ADV
asodahs-128	260	13	those	those	PRON
asodahs-128	260	14	required	require	VERB
asodahs-128	260	15	for	for	ADP
asodahs-128	260	16	globin	globin	NOUN
asodahs-128	260	17	chain	chain	NOUN
asodahs-128	260	18	synthesis	synthesis	NOUN
asodahs-128	260	19	—	—	PUNCT
asodahs-128	260	20	thus	thus	ADV
asodahs-128	260	21	limiting	limit	VERB
asodahs-128	260	22	the	the	DET
asodahs-128	260	23	capacity	capacity	NOUN
asodahs-128	260	24	of	of	ADP
asodahs-128	260	25	the	the	DET
asodahs-128	260	26	bone	bone	NOUN
asodahs-128	260	27	marrow	marrow	NOUN
asodahs-128	260	28	to	to	PART
asodahs-128	260	29	produce	produce	VERB
asodahs-128	260	30	functional	functional	ADJ
asodahs-128	260	31	erythrocytes	erythrocyte	NOUN
asodahs-128	260	32	.	.	PUNCT
asodahs-128	261	1	the	the	DET
asodahs-128	261	2	result	result	NOUN
asodahs-128	261	3	is	be	AUX
asodahs-128	261	4	persistent	persistent	ADJ
asodahs-128	261	5	or	or	CCONJ
asodahs-128	261	6	worsening	worsen	VERB
asodahs-128	261	7	anemia	anemia	NOUN
asodahs-128	261	8	,	,	PUNCT
asodahs-128	261	9	even	even	ADV
asodahs-128	261	10	in	in	ADP
asodahs-128	261	11	the	the	DET
asodahs-128	261	12	absence	absence	NOUN
asodahs-128	261	13	of	of	ADP
asodahs-128	261	14	overt	overt	ADJ
asodahs-128	261	15	clinical	clinical	ADJ
asodahs-128	261	16	crises	crisis	NOUN
asodahs-128	261	17	.	.	PUNCT
asodahs-128	262	1	inadequate	inadequate	ADJ
asodahs-128	262	2	protein	protein	NOUN
asodahs-128	262	3	status	status	NOUN
asodahs-128	262	4	may	may	AUX
asodahs-128	262	5	also	also	ADV
asodahs-128	262	6	impair	impair	VERB
asodahs-128	262	7	the	the	DET
asodahs-128	262	8	responsiveness	responsiveness	NOUN
asodahs-128	262	9	to	to	PART
asodahs-128	262	10	erythropoietin	erythropoietin	VERB
asodahs-128	262	11	,	,	PUNCT
asodahs-128	262	12	further	far	ADV
asodahs-128	262	13	blunting	blunt	VERB
asodahs-128	262	14	effective	effective	ADJ
asodahs-128	262	15	erythropoiesis	erythropoiesis	NOUN
asodahs-128	262	16	21	21	NUM
asodahs-128	262	17	.	.	PUNCT
asodahs-128	263	1	moreover	moreover	ADV
asodahs-128	263	2	,	,	PUNCT
asodahs-128	263	3	nitrogen	nitrogen	NOUN
asodahs-128	263	4	imbalance	imbalance	NOUN
asodahs-128	263	5	adversely	adversely	ADV
asodahs-128	263	6	affects	affect	VERB
asodahs-128	263	7	leukocyte	leukocyte	NOUN
asodahs-128	263	8	function	function	NOUN
asodahs-128	263	9	and	and	CCONJ
asodahs-128	263	10	immune	immune	ADJ
asodahs-128	263	11	surveillance	surveillance	NOUN
asodahs-128	263	12	.	.	PUNCT
asodahs-128	264	1	immune	immune	ADJ
asodahs-128	264	2	cells	cell	NOUN
asodahs-128	264	3	,	,	PUNCT
asodahs-128	264	4	particularly	particularly	ADV
asodahs-128	264	5	lymphocytes	lymphocyte	NOUN
asodahs-128	264	6	and	and	CCONJ
asodahs-128	264	7	neutrophils	neutrophil	NOUN
asodahs-128	264	8	,	,	PUNCT
asodahs-128	264	9	require	require	VERB
asodahs-128	264	10	adequate	adequate	ADJ
asodahs-128	264	11	protein	protein	NOUN
asodahs-128	264	12	substrates	substrate	NOUN
asodahs-128	264	13	to	to	PART
asodahs-128	264	14	support	support	VERB
asodahs-128	264	15	proliferation	proliferation	NOUN
asodahs-128	264	16	,	,	PUNCT
asodahs-128	264	17	antibody	antibody	NOUN
asodahs-128	264	18	production	production	NOUN
asodahs-128	264	19	,	,	PUNCT
asodahs-128	264	20	cytokine	cytokine	ADJ
asodahs-128	264	21	synthesis	synthesis	NOUN
asodahs-128	264	22	,	,	PUNCT
asodahs-128	264	23	and	and	CCONJ
asodahs-128	264	24	cytotoxic	cytotoxic	ADJ
asodahs-128	264	25	activity	activity	NOUN
asodahs-128	264	26	.	.	PUNCT
asodahs-128	265	1	in	in	ADP
asodahs-128	265	2	scd	scd	PROPN
asodahs-128	265	3	,	,	PUNCT
asodahs-128	265	4	where	where	SCONJ
asodahs-128	265	5	individuals	individual	NOUN
asodahs-128	265	6	already	already	ADV
asodahs-128	265	7	face	face	VERB
asodahs-128	265	8	increased	increase	VERB
asodahs-128	265	9	susceptibility	susceptibility	NOUN
asodahs-128	265	10	to	to	ADP
asodahs-128	265	11	infections	infection	NOUN
asodahs-128	265	12	due	due	ADP
asodahs-128	265	13	to	to	ADP
asodahs-128	265	14	functional	functional	ADJ
asodahs-128	265	15	asplenia	asplenia	NOUN
asodahs-128	265	16	and	and	CCONJ
asodahs-128	265	17	chronic	chronic	ADJ
asodahs-128	265	18	inflammation	inflammation	NOUN
asodahs-128	265	19	,	,	PUNCT
asodahs-128	265	20	suboptimal	suboptimal	ADJ
asodahs-128	265	21	nitrogen	nitrogen	NOUN
asodahs-128	265	22	status	status	NOUN
asodahs-128	265	23	can	can	AUX
asodahs-128	265	24	exacerbate	exacerbate	VERB
asodahs-128	265	25	immunodeficiency	immunodeficiency	NOUN
asodahs-128	265	26	.	.	PUNCT
asodahs-128	266	1	this	this	PRON
asodahs-128	266	2	predisposes	predispose	VERB
asodahs-128	266	3	patients	patient	NOUN
asodahs-128	266	4	to	to	ADP
asodahs-128	266	5	more	more	ADV
asodahs-128	266	6	frequent	frequent	ADJ
asodahs-128	266	7	and	and	CCONJ
asodahs-128	266	8	severe	severe	ADJ
asodahs-128	266	9	infections	infection	NOUN
asodahs-128	266	10	,	,	PUNCT
asodahs-128	266	11	leading	lead	VERB
asodahs-128	266	12	to	to	ADP
asodahs-128	266	13	increased	increase	VERB
asodahs-128	266	14	hospitalizations	hospitalization	NOUN
asodahs-128	266	15	and	and	CCONJ
asodahs-128	266	16	prolonged	prolonged	ADJ
asodahs-128	266	17	disease	disease	NOUN
asodahs-128	266	18	flares	flare	VERB
asodahs-128	266	19	22	22	NUM
asodahs-128	266	20	.	.	PUNCT
asodahs-128	267	1	platelet	platelet	NOUN
asodahs-128	267	2	function	function	NOUN
asodahs-128	267	3	and	and	CCONJ
asodahs-128	267	4	coagulation	coagulation	NOUN
asodahs-128	267	5	dynamics	dynamic	NOUN
asodahs-128	267	6	may	may	AUX
asodahs-128	267	7	also	also	ADV
asodahs-128	267	8	be	be	AUX
asodahs-128	267	9	influenced	influence	VERB
asodahs-128	267	10	by	by	ADP
asodahs-128	267	11	protein	protein	NOUN
asodahs-128	267	12	and	and	CCONJ
asodahs-128	267	13	nitrogen	nitrogen	NOUN
asodahs-128	267	14	deficiencies	deficiency	NOUN
asodahs-128	267	15	.	.	PUNCT
asodahs-128	268	1	platelets	platelet	NOUN
asodahs-128	268	2	rely	rely	VERB
asodahs-128	268	3	on	on	ADP
asodahs-128	268	4	structural	structural	ADJ
asodahs-128	268	5	proteins	protein	NOUN
asodahs-128	268	6	and	and	CCONJ
asodahs-128	268	7	enzymatic	enzymatic	ADJ
asodahs-128	268	8	systems	system	NOUN
asodahs-128	268	9	that	that	PRON
asodahs-128	268	10	are	be	AUX
asodahs-128	268	11	nitrogen	nitrogen	NOUN
asodahs-128	268	12	-	-	PUNCT
asodahs-128	268	13	dependent	dependent	ADJ
asodahs-128	268	14	.	.	PUNCT
asodahs-128	269	1	a	a	DET
asodahs-128	269	2	compromised	compromise	VERB
asodahs-128	269	3	nitrogen	nitrogen	NOUN
asodahs-128	269	4	pool	pool	NOUN
asodahs-128	269	5	may	may	AUX
asodahs-128	269	6	impair	impair	VERB
asodahs-128	269	7	platelet	platelet	NOUN
asodahs-128	269	8	aggregation	aggregation	NOUN
asodahs-128	269	9	and	and	CCONJ
asodahs-128	269	10	contribute	contribute	VERB
asodahs-128	269	11	to	to	ADP
asodahs-128	269	12	the	the	DET
asodahs-128	269	13	dysregulation	dysregulation	NOUN
asodahs-128	269	14	of	of	ADP
asodahs-128	269	15	the	the	DET
asodahs-128	269	16	coagulation	coagulation	NOUN
asodahs-128	269	17	cascade	cascade	NOUN
asodahs-128	269	18	—	—	PUNCT
asodahs-128	269	19	factors	factor	NOUN
asodahs-128	269	20	that	that	PRON
asodahs-128	269	21	play	play	VERB
asodahs-128	269	22	a	a	DET
asodahs-128	269	23	role	role	NOUN
asodahs-128	269	24	in	in	ADP
asodahs-128	269	25	the	the	DET
asodahs-128	269	26	pathogenesis	pathogenesis	NOUN
asodahs-128	269	27	of	of	ADP
asodahs-128	269	28	vaso	vaso	PROPN
asodahs-128	269	29	-	-	PUNCT
asodahs-128	269	30	occlusive	occlusive	ADJ
asodahs-128	269	31	crises	crisis	NOUN
asodahs-128	269	32	.	.	PUNCT
asodahs-128	270	1	additionally	additionally	ADV
asodahs-128	270	2	,	,	PUNCT
asodahs-128	270	3	the	the	DET
asodahs-128	270	4	repair	repair	NOUN
asodahs-128	270	5	of	of	ADP
asodahs-128	270	6	endothelial	endothelial	ADJ
asodahs-128	270	7	damage	damage	NOUN
asodahs-128	270	8	,	,	PUNCT
asodahs-128	270	9	a	a	DET
asodahs-128	270	10	key	key	ADJ
asodahs-128	270	11	process	process	NOUN
asodahs-128	270	12	in	in	ADP
asodahs-128	270	13	preserving	preserve	VERB
asodahs-128	270	14	vascular	vascular	ADJ
asodahs-128	270	15	integrity	integrity	NOUN
asodahs-128	270	16	in	in	ADP
asodahs-128	270	17	scd	scd	PROPN
asodahs-128	270	18	,	,	PUNCT
asodahs-128	270	19	requires	require	VERB
asodahs-128	270	20	sufficient	sufficient	ADJ
asodahs-128	270	21	amino	amino	NOUN
asodahs-128	270	22	acids	acid	NOUN
asodahs-128	270	23	for	for	ADP
asodahs-128	270	24	collagen	collagen	NOUN
asodahs-128	270	25	formation	formation	NOUN
asodahs-128	270	26	and	and	CCONJ
asodahs-128	270	27	other	other	ADJ
asodahs-128	270	28	reparative	reparative	ADJ
asodahs-128	270	29	mechanisms	mechanism	NOUN
asodahs-128	270	30	23	23	NUM
asodahs-128	270	31	.	.	PUNCT
asodahs-128	271	1	nitrogen	nitrogen	NOUN
asodahs-128	271	2	imbalance	imbalance	NOUN
asodahs-128	271	3	may	may	AUX
asodahs-128	271	4	also	also	ADV
asodahs-128	271	5	influence	influence	VERB
asodahs-128	271	6	the	the	DET
asodahs-128	271	7	redox	redox	ADJ
asodahs-128	271	8	status	status	NOUN
asodahs-128	271	9	of	of	ADP
asodahs-128	271	10	sickle	sickle	NOUN
asodahs-128	271	11	cell	cell	NOUN
asodahs-128	271	12	patients	patient	NOUN
asodahs-128	271	13	.	.	PUNCT
asodahs-128	272	1	antioxidant	antioxidant	ADJ
asodahs-128	272	2	enzymes	enzyme	NOUN
asodahs-128	272	3	such	such	ADJ
asodahs-128	272	4	as	as	ADP
asodahs-128	272	5	glutathione	glutathione	NOUN
asodahs-128	272	6	peroxidase	peroxidase	NOUN
asodahs-128	272	7	,	,	PUNCT
asodahs-128	272	8	superoxide	superoxide	NOUN
asodahs-128	272	9	dismutase	dismutase	NOUN
asodahs-128	272	10	,	,	PUNCT
asodahs-128	272	11	and	and	CCONJ
asodahs-128	272	12	catalase	catalase	NOUN
asodahs-128	272	13	are	be	AUX
asodahs-128	272	14	protein	protein	NOUN
asodahs-128	272	15	-	-	PUNCT
asodahs-128	272	16	based	base	VERB
asodahs-128	272	17	and	and	CCONJ
asodahs-128	272	18	require	require	VERB
asodahs-128	272	19	nitrogen	nitrogen	NOUN
asodahs-128	272	20	for	for	ADP
asodahs-128	272	21	their	their	PRON
asodahs-128	272	22	synthesis	synthesis	NOUN
asodahs-128	272	23	.	.	PUNCT
asodahs-128	273	1	in	in	ADP
asodahs-128	273	2	a	a	DET
asodahs-128	273	3	state	state	NOUN
asodahs-128	273	4	of	of	ADP
asodahs-128	273	5	nitrogen	nitrogen	NOUN
asodahs-128	273	6	deficiency	deficiency	NOUN
asodahs-128	273	7	,	,	PUNCT
asodahs-128	273	8	the	the	DET
asodahs-128	273	9	capacity	capacity	NOUN
asodahs-128	273	10	to	to	PART
asodahs-128	273	11	synthesize	synthesize	VERB
asodahs-128	273	12	these	these	DET
asodahs-128	273	13	protective	protective	ADJ
asodahs-128	273	14	enzymes	enzyme	NOUN
asodahs-128	273	15	may	may	AUX
asodahs-128	273	16	be	be	AUX
asodahs-128	273	17	diminished	diminish	VERB
asodahs-128	273	18	,	,	PUNCT
asodahs-128	273	19	leading	lead	VERB
asodahs-128	273	20	to	to	ADP
asodahs-128	273	21	oxidative	oxidative	ADJ
asodahs-128	273	22	stress	stress	NOUN
asodahs-128	273	23	—	—	PUNCT
asodahs-128	273	24	a	a	DET
asodahs-128	273	25	known	know	VERB
asodahs-128	273	26	aggravator	aggravator	NOUN
asodahs-128	273	27	of	of	ADP
asodahs-128	273	28	erythrocyte	erythrocyte	NOUN
asodahs-128	273	29	sickling	sickling	NOUN
asodahs-128	273	30	and	and	CCONJ
asodahs-128	273	31	hemolysis	hemolysis	NOUN
asodahs-128	273	32	.	.	PUNCT
asodahs-128	274	1	this	this	PRON
asodahs-128	274	2	creates	create	VERB
asodahs-128	274	3	a	a	DET
asodahs-128	274	4	vicious	vicious	ADJ
asodahs-128	274	5	cycle	cycle	NOUN
asodahs-128	274	6	in	in	ADP
asodahs-128	274	7	which	which	PRON
asodahs-128	274	8	nitrogen	nitrogen	NOUN
asodahs-128	274	9	imbalance	imbalance	NOUN
asodahs-128	274	10	worsens	worsen	VERB
asodahs-128	274	11	oxidative	oxidative	ADJ
asodahs-128	274	12	damage	damage	NOUN
asodahs-128	274	13	,	,	PUNCT
asodahs-128	274	14	which	which	PRON
asodahs-128	274	15	in	in	ADP
asodahs-128	274	16	turn	turn	NOUN
asodahs-128	274	17	accelerates	accelerate	VERB
asodahs-128	274	18	hemolysis	hemolysis	NOUN
asodahs-128	274	19	and	and	CCONJ
asodahs-128	274	20	protein	protein	NOUN
asodahs-128	274	21	turnover	turnover	NOUN
asodahs-128	274	22	24	24	NUM
asodahs-128	274	23	.	.	PUNCT
asodahs-128	275	1	in	in	ADP
asodahs-128	275	2	pediatric	pediatric	ADJ
asodahs-128	275	3	scd	scd	NOUN
asodahs-128	275	4	patients	patient	NOUN
asodahs-128	275	5	,	,	PUNCT
asodahs-128	275	6	nitrogen	nitrogen	NOUN
asodahs-128	275	7	imbalance	imbalance	NOUN
asodahs-128	275	8	has	have	AUX
asodahs-128	275	9	been	be	AUX
asodahs-128	275	10	linked	link	VERB
asodahs-128	275	11	with	with	ADP
asodahs-128	275	12	impaired	impaired	ADJ
asodahs-128	275	13	growth	growth	NOUN
asodahs-128	275	14	and	and	CCONJ
asodahs-128	275	15	delayed	delay	VERB
asodahs-128	275	16	developmental	developmental	ADJ
asodahs-128	275	17	milestones	milestone	NOUN
asodahs-128	275	18	.	.	PUNCT
asodahs-128	276	1	these	these	DET
asodahs-128	276	2	hematological	hematological	ADJ
asodahs-128	276	3	and	and	CCONJ
asodahs-128	276	4	systemic	systemic	ADJ
asodahs-128	276	5	deficiencies	deficiency	NOUN
asodahs-128	276	6	not	not	PART
asodahs-128	276	7	only	only	ADV
asodahs-128	276	8	reflect	reflect	VERB
asodahs-128	276	9	poor	poor	ADJ
asodahs-128	276	10	protein	protein	NOUN
asodahs-128	276	11	-	-	PUNCT
asodahs-128	276	12	nutritional	nutritional	ADJ
asodahs-128	276	13	status	status	NOUN
asodahs-128	276	14	but	but	CCONJ
asodahs-128	276	15	also	also	ADV
asodahs-128	276	16	impact	impact	VERB
asodahs-128	276	17	the	the	DET
asodahs-128	276	18	long	long	ADJ
asodahs-128	276	19	-	-	PUNCT
asodahs-128	276	20	term	term	NOUN
asodahs-128	276	21	prognosis	prognosis	NOUN
asodahs-128	276	22	of	of	ADP
asodahs-128	276	23	affected	affected	ADJ
asodahs-128	276	24	children	child	NOUN
asodahs-128	276	25	.	.	PUNCT
asodahs-128	277	1	poor	poor	ADJ
asodahs-128	277	2	hemoglobin	hemoglobin	NOUN
asodahs-128	277	3	levels	level	NOUN
asodahs-128	277	4	,	,	PUNCT
asodahs-128	277	5	immune	immune	ADJ
asodahs-128	277	6	suppression	suppression	NOUN
asodahs-128	277	7	,	,	PUNCT
asodahs-128	277	8	and	and	CCONJ
asodahs-128	277	9	slowed	slow	VERB
asodahs-128	277	10	somatic	somatic	ADJ
asodahs-128	277	11	growth	growth	NOUN
asodahs-128	277	12	cumulatively	cumulatively	ADV
asodahs-128	277	13	reduce	reduce	VERB
asodahs-128	277	14	quality	quality	NOUN
asodahs-128	277	15	of	of	ADP
asodahs-128	277	16	life	life	NOUN
asodahs-128	277	17	and	and	CCONJ
asodahs-128	277	18	functional	functional	ADJ
asodahs-128	277	19	capacity	capacity	NOUN
asodahs-128	277	20	,	,	PUNCT
asodahs-128	277	21	emphasizing	emphasize	VERB
asodahs-128	277	22	the	the	DET
asodahs-128	277	23	clinical	clinical	ADJ
asodahs-128	277	24	urgency	urgency	NOUN
asodahs-128	277	25	of	of	ADP
asodahs-128	277	26	addressing	address	VERB
asodahs-128	277	27	nitrogen	nitrogen	NOUN
asodahs-128	277	28	balance	balance	NOUN
asodahs-128	277	29	25	25	NUM
asodahs-128	277	30	-	-	SYM
asodahs-128	277	31	26	26	NUM
asodahs-128	277	32	.	.	PUNCT
asodahs-128	278	1	clinical	clinical	ADJ
asodahs-128	278	2	and	and	CCONJ
asodahs-128	278	3	nutritional	nutritional	ADJ
asodahs-128	278	4	interventions	intervention	NOUN
asodahs-128	278	5	effective	effective	ADJ
asodahs-128	278	6	management	management	NOUN
asodahs-128	278	7	of	of	ADP
asodahs-128	278	8	nitrogen	nitrogen	NOUN
asodahs-128	278	9	imbalance	imbalance	NOUN
asodahs-128	278	10	in	in	ADP
asodahs-128	278	11	sickle	sickle	NOUN
asodahs-128	278	12	cell	cell	NOUN
asodahs-128	278	13	disease	disease	NOUN
asodahs-128	278	14	(	(	PUNCT
asodahs-128	278	15	scd	scd	NOUN
asodahs-128	278	16	)	)	PUNCT
asodahs-128	278	17	necessitates	necessitate	VERB
asodahs-128	278	18	a	a	DET
asodahs-128	278	19	multifaceted	multifaceted	ADJ
asodahs-128	278	20	approach	approach	NOUN
asodahs-128	278	21	that	that	PRON
asodahs-128	278	22	integrates	integrate	VERB
asodahs-128	278	23	clinical	clinical	ADJ
asodahs-128	278	24	care	care	NOUN
asodahs-128	278	25	with	with	ADP
asodahs-128	278	26	targeted	target	VERB
asodahs-128	278	27	nutritional	nutritional	ADJ
asodahs-128	278	28	strategies	strategy	NOUN
asodahs-128	278	29	.	.	PUNCT
asodahs-128	279	1	due	due	ADP
asodahs-128	279	2	to	to	ADP
asodahs-128	279	3	the	the	DET
asodahs-128	279	4	chronic	chronic	ADJ
asodahs-128	279	5	catabolic	catabolic	ADJ
asodahs-128	279	6	state	state	NOUN
asodahs-128	279	7	and	and	CCONJ
asodahs-128	279	8	elevated	elevated	ADJ
asodahs-128	279	9	protein	protein	NOUN
asodahs-128	279	10	turnover	turnover	NOUN
asodahs-128	279	11	associated	associate	VERB
asodahs-128	279	12	with	with	ADP
asodahs-128	279	13	scd	scd	PROPN
asodahs-128	279	14	,	,	PUNCT
asodahs-128	279	15	particularly	particularly	ADV
asodahs-128	279	16	during	during	ADP
asodahs-128	279	17	vaso	vaso	NOUN
asodahs-128	279	18	-	-	PUNCT
asodahs-128	279	19	occlusive	occlusive	ADJ
asodahs-128	279	20	crises	crisis	NOUN
asodahs-128	279	21	or	or	CCONJ
asodahs-128	279	22	infections	infection	NOUN
asodahs-128	279	23	,	,	PUNCT
asodahs-128	279	24	conventional	conventional	ADJ
asodahs-128	279	25	nutritional	nutritional	ADJ
asodahs-128	279	26	recommendations	recommendation	NOUN
asodahs-128	279	27	often	often	ADV
asodahs-128	279	28	fall	fall	VERB
asodahs-128	279	29	short	short	ADV
asodahs-128	279	30	of	of	ADP
asodahs-128	279	31	meeting	meet	VERB
asodahs-128	279	32	the	the	DET
asodahs-128	279	33	metabolic	metabolic	NOUN
asodahs-128	279	34	demands	demand	NOUN
asodahs-128	279	35	of	of	ADP
asodahs-128	279	36	these	these	DET
asodahs-128	279	37	patients	patient	NOUN
asodahs-128	279	38	.	.	PUNCT
asodahs-128	280	1	clinical	clinical	ADJ
asodahs-128	280	2	and	and	CCONJ
asodahs-128	280	3	dietary	dietary	ADJ
asodahs-128	280	4	interventions	intervention	NOUN
asodahs-128	280	5	must	must	AUX
asodahs-128	280	6	therefore	therefore	ADV
asodahs-128	280	7	be	be	AUX
asodahs-128	280	8	proactive	proactive	ADJ
asodahs-128	280	9	,	,	PUNCT
asodahs-128	280	10	personalized	personalized	ADJ
asodahs-128	280	11	,	,	PUNCT
asodahs-128	280	12	and	and	CCONJ
asodahs-128	280	13	based	base	VERB
asodahs-128	280	14	on	on	ADP
asodahs-128	280	15	a	a	DET
asodahs-128	280	16	comprehensive	comprehensive	ADJ
asodahs-128	280	17	understanding	understanding	NOUN
asodahs-128	280	18	of	of	ADP
asodahs-128	280	19	individual	individual	ADJ
asodahs-128	280	20	needs	need	NOUN
asodahs-128	280	21	[	[	X
asodahs-128	280	22	2729	2729	NUM
asodahs-128	280	23	]	]	PUNCT
asodahs-128	280	24	.	.	PUNCT
asodahs-128	281	1	clinically	clinically	ADV
asodahs-128	281	2	,	,	PUNCT
asodahs-128	281	3	routine	routine	ADJ
asodahs-128	281	4	assessment	assessment	NOUN
asodahs-128	281	5	of	of	ADP
asodahs-128	281	6	nutritional	nutritional	ADJ
asodahs-128	281	7	status	status	NOUN
asodahs-128	281	8	should	should	AUX
asodahs-128	281	9	be	be	AUX
asodahs-128	281	10	incorporated	incorporate	VERB
asodahs-128	281	11	into	into	ADP
asodahs-128	281	12	standard	standard	ADJ
asodahs-128	281	13	care	care	NOUN
asodahs-128	281	14	for	for	ADP
asodahs-128	281	15	scd	scd	NOUN
asodahs-128	281	16	patients	patient	NOUN
asodahs-128	281	17	,	,	PUNCT
asodahs-128	281	18	including	include	VERB
asodahs-128	281	19	regular	regular	ADJ
asodahs-128	281	20	evaluations	evaluation	NOUN
asodahs-128	281	21	of	of	ADP
asodahs-128	281	22	serum	serum	NOUN
asodahs-128	281	23	protein	protein	NOUN
asodahs-128	281	24	levels	level	NOUN
asodahs-128	281	25	,	,	PUNCT
asodahs-128	281	26	body	body	NOUN
asodahs-128	281	27	mass	mass	NOUN
asodahs-128	281	28	index	index	NOUN
asodahs-128	281	29	(	(	PUNCT
asodahs-128	281	30	bmi	bmi	PROPN
asodahs-128	281	31	)	)	PUNCT
asodahs-128	281	32	,	,	PUNCT
asodahs-128	281	33	and	and	CCONJ
asodahs-128	281	34	markers	marker	NOUN
asodahs-128	281	35	of	of	ADP
asodahs-128	281	36	nitrogen	nitrogen	NOUN
asodahs-128	281	37	excretion	excretion	NOUN
asodahs-128	281	38	,	,	PUNCT
asodahs-128	281	39	such	such	ADJ
asodahs-128	281	40	as	as	ADP
asodahs-128	281	41	urinary	urinary	ADJ
asodahs-128	281	42	urea	urea	NOUN
asodahs-128	281	43	nitrogen	nitrogen	NOUN
asodahs-128	281	44	.	.	PUNCT
asodahs-128	282	1	where	where	SCONJ
asodahs-128	282	2	feasible	feasible	ADJ
asodahs-128	282	3	,	,	PUNCT
asodahs-128	282	4	indirect	indirect	ADJ
asodahs-128	282	5	calorimetry	calorimetry	NOUN
asodahs-128	282	6	and	and	CCONJ
asodahs-128	282	7	nitrogen	nitrogen	NOUN
asodahs-128	282	8	balance	balance	NOUN
asodahs-128	282	9	studies	study	NOUN
asodahs-128	282	10	may	may	AUX
asodahs-128	282	11	provide	provide	VERB
asodahs-128	282	12	more	more	ADV
asodahs-128	282	13	accurate	accurate	ADJ
asodahs-128	282	14	estimates	estimate	NOUN
asodahs-128	282	15	of	of	ADP
asodahs-128	282	16	metabolic	metabolic	NOUN
asodahs-128	282	17	demand	demand	NOUN
asodahs-128	282	18	.	.	PUNCT
asodahs-128	283	1	in	in	ADP
asodahs-128	283	2	patients	patient	NOUN
asodahs-128	283	3	with	with	ADP
asodahs-128	283	4	evidence	evidence	NOUN
asodahs-128	283	5	of	of	ADP
asodahs-128	283	6	nitrogen	nitrogen	NOUN
asodahs-128	283	7	deficit	deficit	NOUN
asodahs-128	283	8	,	,	PUNCT
asodahs-128	283	9	medical	medical	ADJ
asodahs-128	283	10	nutrition	nutrition	NOUN
asodahs-128	283	11	therapy	therapy	NOUN
asodahs-128	283	12	should	should	AUX
asodahs-128	283	13	be	be	AUX
asodahs-128	283	14	initiated	initiate	VERB
asodahs-128	283	15	under	under	ADP
asodahs-128	283	16	the	the	DET
asodahs-128	283	17	guidance	guidance	NOUN
asodahs-128	283	18	of	of	ADP
asodahs-128	283	19	dietitians	dietitian	NOUN
asodahs-128	283	20	experienced	experience	VERB
asodahs-128	283	21	in	in	ADP
asodahs-128	283	22	hematologic	hematologic	NOUN
asodahs-128	283	23	and	and	CCONJ
asodahs-128	283	24	metabolic	metabolic	NOUN
asodahs-128	283	25	disorders	disorder	NOUN
asodahs-128	283	26	[	[	X
asodahs-128	283	27	30	30	NUM
asodahs-128	283	28	-	-	SYM
asodahs-128	283	29	32	32	NUM
asodahs-128	283	30	]	]	PUNCT
asodahs-128	283	31	.	.	PUNCT
asodahs-128	284	1	from	from	ADP
asodahs-128	284	2	a	a	DET
asodahs-128	284	3	nutritional	nutritional	ADJ
asodahs-128	284	4	standpoint	standpoint	NOUN
asodahs-128	284	5	,	,	PUNCT
asodahs-128	284	6	increasing	increase	VERB
asodahs-128	284	7	dietary	dietary	ADJ
asodahs-128	284	8	protein	protein	NOUN
asodahs-128	284	9	intake	intake	NOUN
asodahs-128	284	10	is	be	AUX
asodahs-128	284	11	the	the	DET
asodahs-128	284	12	cornerstone	cornerstone	NOUN
asodahs-128	284	13	of	of	ADP
asodahs-128	284	14	restoring	restore	VERB
asodahs-128	284	15	nitrogen	nitrogen	NOUN
asodahs-128	284	16	balance	balance	NOUN
asodahs-128	284	17	.	.	PUNCT
asodahs-128	285	1	the	the	DET
asodahs-128	285	2	recommended	recommend	VERB
asodahs-128	285	3	daily	daily	ADJ
asodahs-128	285	4	allowance	allowance	NOUN
asodahs-128	285	5	(	(	PUNCT
asodahs-128	285	6	rda	rda	NOUN
asodahs-128	285	7	)	)	PUNCT
asodahs-128	285	8	for	for	ADP
asodahs-128	285	9	protein	protein	NOUN
asodahs-128	285	10	may	may	AUX
asodahs-128	285	11	need	need	VERB
asodahs-128	285	12	to	to	PART
asodahs-128	285	13	be	be	AUX
asodahs-128	285	14	significantly	significantly	ADV
asodahs-128	285	15	increased	increase	VERB
asodahs-128	285	16	in	in	ADP
asodahs-128	285	17	scd	scd	NOUN
asodahs-128	285	18	patients	patient	NOUN
asodahs-128	285	19	,	,	PUNCT
asodahs-128	285	20	particularly	particularly	ADV
asodahs-128	285	21	during	during	ADP
asodahs-128	285	22	periods	period	NOUN
asodahs-128	285	23	of	of	ADP
asodahs-128	285	24	increased	increase	VERB
asodahs-128	285	25	stress	stress	NOUN
asodahs-128	285	26	or	or	CCONJ
asodahs-128	285	27	recovery	recovery	NOUN
asodahs-128	285	28	.	.	PUNCT
asodahs-128	286	1	highbiological	highbiological	ADJ
asodahs-128	286	2	-	-	PUNCT
asodahs-128	286	3	value	value	NOUN
asodahs-128	286	4	proteins	protein	NOUN
asodahs-128	286	5	—	—	PUNCT
asodahs-128	286	6	such	such	ADJ
asodahs-128	286	7	as	as	ADP
asodahs-128	286	8	those	those	PRON
asodahs-128	286	9	from	from	ADP
asodahs-128	286	10	eggs	egg	NOUN
asodahs-128	286	11	,	,	PUNCT
asodahs-128	286	12	dairy	dairy	NOUN
asodahs-128	286	13	,	,	PUNCT
asodahs-128	286	14	lean	lean	ADJ
asodahs-128	286	15	meats	meat	NOUN
asodahs-128	286	16	,	,	PUNCT
asodahs-128	286	17	fish	fish	NOUN
asodahs-128	286	18	,	,	PUNCT
asodahs-128	286	19	and	and	CCONJ
asodahs-128	286	20	legumes	legume	NOUN
asodahs-128	286	21	—	—	PUNCT
asodahs-128	286	22	should	should	AUX
asodahs-128	286	23	be	be	AUX
asodahs-128	286	24	prioritized	prioritize	VERB
asodahs-128	286	25	to	to	PART
asodahs-128	286	26	ensure	ensure	VERB
asodahs-128	286	27	the	the	DET
asodahs-128	286	28	supply	supply	NOUN
asodahs-128	286	29	of	of	ADP
asodahs-128	286	30	essential	essential	ADJ
asodahs-128	286	31	amino	amino	ADJ
asodahs-128	286	32	acids	acid	NOUN
asodahs-128	286	33	.	.	PUNCT
asodahs-128	287	1	supplemental	supplemental	ADJ
asodahs-128	287	2	formulations	formulation	NOUN
asodahs-128	287	3	containing	contain	VERB
asodahs-128	287	4	branched	branch	VERB
asodahs-128	287	5	-	-	PUNCT
asodahs-128	287	6	chain	chain	NOUN
asodahs-128	287	7	amino	amino	NOUN
asodahs-128	287	8	acids	acid	NOUN
asodahs-128	287	9	(	(	PUNCT
asodahs-128	287	10	bcaas	bcaas	NOUN
asodahs-128	287	11	)	)	PUNCT
asodahs-128	287	12	,	,	PUNCT
asodahs-128	287	13	glutamine	glutamine	NOUN
asodahs-128	287	14	,	,	PUNCT
asodahs-128	287	15	and	and	CCONJ
asodahs-128	287	16	arginine	arginine	NOUN
asodahs-128	287	17	have	have	AUX
asodahs-128	287	18	also	also	ADV
asodahs-128	287	19	been	be	AUX
asodahs-128	287	20	studied	study	VERB
asodahs-128	287	21	for	for	ADP
asodahs-128	287	22	their	their	PRON
asodahs-128	287	23	role	role	NOUN
asodahs-128	287	24	in	in	ADP
asodahs-128	287	25	promoting	promote	VERB
asodahs-128	287	26	nitrogen	nitrogen	NOUN
asodahs-128	287	27	retention	retention	NOUN
asodahs-128	287	28	and	and	CCONJ
asodahs-128	287	29	tissue	tissue	NOUN
asodahs-128	287	30	repair	repair	NOUN
asodahs-128	287	31	,	,	PUNCT
asodahs-128	287	32	with	with	ADP
asodahs-128	287	33	promising	promising	ADJ
asodahs-128	287	34	but	but	CCONJ
asodahs-128	287	35	still	still	ADV
asodahs-128	287	36	emerging	emerge	VERB
asodahs-128	287	37	evidence	evidence	NOUN
asodahs-128	287	38	33	33	NUM
asodahs-128	287	39	-	-	SYM
asodahs-128	287	40	34	34	NUM
asodahs-128	287	41	.	.	PUNCT
asodahs-128	288	1	micronutrient	micronutrient	NOUN
asodahs-128	288	2	support	support	NOUN
asodahs-128	288	3	plays	play	VERB
asodahs-128	288	4	a	a	DET
asodahs-128	288	5	complementary	complementary	ADJ
asodahs-128	288	6	role	role	NOUN
asodahs-128	288	7	.	.	PUNCT
asodahs-128	289	1	zinc	zinc	NOUN
asodahs-128	289	2	,	,	PUNCT
asodahs-128	289	3	folate	folate	NOUN
asodahs-128	289	4	,	,	PUNCT
asodahs-128	289	5	and	and	CCONJ
asodahs-128	289	6	vitamin	vitamin	NOUN
asodahs-128	289	7	b12	b12	NOUN
asodahs-128	289	8	are	be	AUX
asodahs-128	289	9	crucial	crucial	ADJ
asodahs-128	289	10	for	for	ADP
asodahs-128	289	11	dna	dna	PROPN
asodahs-128	289	12	synthesis	synthesis	NOUN
asodahs-128	289	13	,	,	PUNCT
asodahs-128	289	14	erythropoiesis	erythropoiesis	NOUN
asodahs-128	289	15	,	,	PUNCT
asodahs-128	289	16	and	and	CCONJ
asodahs-128	289	17	immune	immune	ADJ
asodahs-128	289	18	function	function	NOUN
asodahs-128	289	19	,	,	PUNCT
asodahs-128	289	20	all	all	PRON
asodahs-128	289	21	of	of	ADP
asodahs-128	289	22	which	which	PRON
asodahs-128	289	23	are	be	AUX
asodahs-128	289	24	nitrogen	nitrogen	NOUN
asodahs-128	289	25	-	-	PUNCT
asodahs-128	289	26	dependent	dependent	ADJ
asodahs-128	289	27	processes	process	NOUN
asodahs-128	289	28	.	.	PUNCT
asodahs-128	290	1	ensuring	ensure	VERB
asodahs-128	290	2	adequate	adequate	ADJ
asodahs-128	290	3	intake	intake	NOUN
asodahs-128	290	4	of	of	ADP
asodahs-128	290	5	these	these	DET
asodahs-128	290	6	nutrients	nutrient	NOUN
asodahs-128	290	7	can	can	AUX
asodahs-128	290	8	enhance	enhance	VERB
asodahs-128	290	9	the	the	DET
asodahs-128	290	10	effectiveness	effectiveness	NOUN
asodahs-128	290	11	of	of	ADP
asodahs-128	290	12	protein	protein	NOUN
asodahs-128	290	13	utilization	utilization	NOUN
asodahs-128	290	14	and	and	CCONJ
asodahs-128	290	15	support	support	VERB
asodahs-128	290	16	hematopoietic	hematopoietic	ADJ
asodahs-128	290	17	function	function	NOUN
asodahs-128	290	18	.	.	PUNCT
asodahs-128	291	1	additionally	additionally	ADV
asodahs-128	291	2	,	,	PUNCT
asodahs-128	291	3	antioxidants	antioxidant	NOUN
asodahs-128	291	4	such	such	ADJ
asodahs-128	291	5	as	as	ADP
asodahs-128	291	6	vitamins	vitamin	NOUN
asodahs-128	291	7	c	c	NOUN
asodahs-128	291	8	and	and	CCONJ
asodahs-128	291	9	e	e	NOUN
asodahs-128	291	10	may	may	AUX
asodahs-128	291	11	reduce	reduce	VERB
asodahs-128	291	12	oxidative	oxidative	ADJ
asodahs-128	291	13	stress	stress	NOUN
asodahs-128	291	14	,	,	PUNCT
asodahs-128	291	15	indirectly	indirectly	ADV
asodahs-128	291	16	lowering	lower	VERB
asodahs-128	291	17	protein	protein	NOUN
asodahs-128	291	18	degradation	degradation	NOUN
asodahs-128	291	19	and	and	CCONJ
asodahs-128	291	20	conserving	conserve	VERB
asodahs-128	291	21	nitrogen	nitrogen	NOUN
asodahs-128	291	22	stores	store	NOUN
asodahs-128	291	23	35	35	NUM
asodahs-128	291	24	.	.	PUNCT
asodahs-128	292	1	in	in	ADP
asodahs-128	292	2	severe	severe	ADJ
asodahs-128	292	3	or	or	CCONJ
asodahs-128	292	4	complicated	complicated	ADJ
asodahs-128	292	5	cases	case	NOUN
asodahs-128	292	6	—	—	PUNCT
asodahs-128	292	7	such	such	ADJ
asodahs-128	292	8	as	as	ADP
asodahs-128	292	9	hospitalized	hospitalize	VERB
asodahs-128	292	10	patients	patient	NOUN
asodahs-128	292	11	with	with	ADP
asodahs-128	292	12	poor	poor	ADJ
asodahs-128	292	13	oral	oral	ADJ
asodahs-128	292	14	intake	intake	NOUN
asodahs-128	292	15	,	,	PUNCT
asodahs-128	292	16	malabsorption	malabsorption	NOUN
asodahs-128	292	17	,	,	PUNCT
asodahs-128	292	18	or	or	CCONJ
asodahs-128	292	19	increased	increase	VERB
asodahs-128	292	20	metabolic	metabolic	NOUN
asodahs-128	292	21	demands	demand	NOUN
asodahs-128	292	22	—	—	PUNCT
asodahs-128	292	23	enteral	enteral	ADJ
asodahs-128	292	24	or	or	CCONJ
asodahs-128	292	25	parenteral	parenteral	ADJ
asodahs-128	292	26	nutrition	nutrition	NOUN
asodahs-128	292	27	may	may	AUX
asodahs-128	292	28	be	be	AUX
asodahs-128	292	29	required	require	VERB
asodahs-128	292	30	.	.	PUNCT
asodahs-128	293	1	these	these	DET
asodahs-128	293	2	interventions	intervention	NOUN
asodahs-128	293	3	must	must	AUX
asodahs-128	293	4	be	be	AUX
asodahs-128	293	5	carefully	carefully	ADV
asodahs-128	293	6	monitored	monitor	VERB
asodahs-128	293	7	to	to	PART
asodahs-128	293	8	avoid	avoid	VERB
asodahs-128	293	9	complications	complication	NOUN
asodahs-128	293	10	such	such	ADJ
asodahs-128	293	11	as	as	ADP
asodahs-128	293	12	refeeding	refeede	VERB
asodahs-128	293	13	syndrome	syndrome	NOUN
asodahs-128	293	14	or	or	CCONJ
asodahs-128	293	15	fluid	fluid	ADJ
asodahs-128	293	16	overload	overload	NOUN
asodahs-128	293	17	.	.	PUNCT
asodahs-128	294	1	the	the	DET
asodahs-128	294	2	choice	choice	NOUN
asodahs-128	294	3	of	of	ADP
asodahs-128	294	4	protein	protein	NOUN
asodahs-128	294	5	sources	source	NOUN
asodahs-128	294	6	,	,	PUNCT
asodahs-128	294	7	the	the	DET
asodahs-128	294	8	timing	timing	NOUN
asodahs-128	294	9	of	of	ADP
asodahs-128	294	10	delivery	delivery	NOUN
asodahs-128	294	11	,	,	PUNCT
asodahs-128	294	12	and	and	CCONJ
asodahs-128	294	13	the	the	DET
asodahs-128	294	14	balance	balance	NOUN
asodahs-128	294	15	of	of	ADP
asodahs-128	294	16	macronutrients	macronutrient	NOUN
asodahs-128	294	17	should	should	AUX
asodahs-128	294	18	be	be	AUX
asodahs-128	294	19	tailored	tailor	VERB
asodahs-128	294	20	to	to	ADP
asodahs-128	294	21	the	the	DET
asodahs-128	294	22	patient	patient	NOUN
asodahs-128	294	23	's	's	PART
asodahs-128	294	24	clinical	clinical	ADJ
asodahs-128	294	25	condition	condition	NOUN
asodahs-128	294	26	and	and	CCONJ
asodahs-128	294	27	recovery	recovery	NOUN
asodahs-128	294	28	goals	goal	NOUN
asodahs-128	294	29	36	36	NUM
asodahs-128	294	30	.	.	PUNCT
asodahs-128	295	1	importantly	importantly	ADV
asodahs-128	295	2	,	,	PUNCT
asodahs-128	295	3	education	education	NOUN
asodahs-128	295	4	and	and	CCONJ
asodahs-128	295	5	counseling	counseling	NOUN
asodahs-128	295	6	for	for	ADP
asodahs-128	295	7	patients	patient	NOUN
asodahs-128	295	8	and	and	CCONJ
asodahs-128	295	9	caregivers	caregiver	NOUN
asodahs-128	295	10	are	be	AUX
asodahs-128	295	11	vital	vital	ADJ
asodahs-128	295	12	components	component	NOUN
asodahs-128	295	13	of	of	ADP
asodahs-128	295	14	any	any	DET
asodahs-128	295	15	nutritional	nutritional	ADJ
asodahs-128	295	16	intervention	intervention	NOUN
asodahs-128	295	17	.	.	PUNCT
asodahs-128	296	1	empowering	empower	VERB
asodahs-128	296	2	individuals	individual	NOUN
asodahs-128	296	3	with	with	ADP
asodahs-128	296	4	scd	scd	NOUN
asodahs-128	296	5	and	and	CCONJ
asodahs-128	296	6	their	their	PRON
asodahs-128	296	7	families	family	NOUN
asodahs-128	296	8	to	to	PART
asodahs-128	296	9	understand	understand	VERB
asodahs-128	296	10	the	the	DET
asodahs-128	296	11	importance	importance	NOUN
asodahs-128	296	12	of	of	ADP
asodahs-128	296	13	dietary	dietary	ADJ
asodahs-128	296	14	protein	protein	NOUN
asodahs-128	296	15	,	,	PUNCT
asodahs-128	296	16	hydration	hydration	NOUN
asodahs-128	296	17	,	,	PUNCT
asodahs-128	296	18	and	and	CCONJ
asodahs-128	296	19	nutrient	nutrient	NOUN
asodahs-128	296	20	diversity	diversity	NOUN
asodahs-128	296	21	can	can	AUX
asodahs-128	296	22	lead	lead	VERB
asodahs-128	296	23	to	to	ADP
asodahs-128	296	24	better	well	ADJ
asodahs-128	296	25	compliance	compliance	NOUN
asodahs-128	296	26	and	and	CCONJ
asodahs-128	296	27	long	long	ADJ
asodahs-128	296	28	-	-	PUNCT
asodahs-128	296	29	term	term	NOUN
asodahs-128	296	30	improvements	improvement	NOUN
asodahs-128	296	31	in	in	ADP
asodahs-128	296	32	health	health	NOUN
asodahs-128	296	33	outcomes	outcome	NOUN
asodahs-128	296	34	.	.	PUNCT
asodahs-128	297	1	community	community	NOUN
asodahs-128	297	2	-	-	PUNCT
asodahs-128	297	3	based	base	VERB
asodahs-128	297	4	programs	program	NOUN
asodahs-128	297	5	and	and	CCONJ
asodahs-128	297	6	school	school	NOUN
asodahs-128	297	7	feeding	feeding	NOUN
asodahs-128	297	8	initiatives	initiative	NOUN
asodahs-128	297	9	may	may	AUX
asodahs-128	297	10	also	also	ADV
asodahs-128	297	11	play	play	VERB
asodahs-128	297	12	a	a	DET
asodahs-128	297	13	role	role	NOUN
asodahs-128	297	14	in	in	ADP
asodahs-128	297	15	emmanuel	emmanuel	PROPN
asodahs-128	297	16	ifeanyi	ifeanyi	PROPN
asodahs-128	297	17	obeagu	obeagu	PROPN
asodahs-128	297	18	asian	asian	PROPN
asodahs-128	297	19	journal	journal	PROPN
asodahs-128	297	20	of	of	ADP
asodahs-128	297	21	dental	dental	ADJ
asodahs-128	297	22	and	and	CCONJ
asodahs-128	297	23	health	health	NOUN
asodahs-128	297	24	sciences	science	NOUN
asodahs-128	297	25	.	.	PUNCT
asodahs-128	297	26	2025	2025	NUM
asodahs-128	297	27	;	;	PUNCT
asodahs-128	297	28	5(3):1	5(3):1	NUM
asodahs-128	297	29	-	-	SYM
asodahs-128	297	30	5	5	NUM
asodahs-128	298	1	[	[	X
asodahs-128	298	2	4	4	NUM
asodahs-128	298	3	]	]	PUNCT
asodahs-128	298	4	ajdhs.com	ajdhs.com	X
asodahs-128	298	5	supporting	support	VERB
asodahs-128	298	6	nutritional	nutritional	ADJ
asodahs-128	298	7	sufficiency	sufficiency	NOUN
asodahs-128	298	8	,	,	PUNCT
asodahs-128	298	9	particularly	particularly	ADV
asodahs-128	298	10	in	in	ADP
asodahs-128	298	11	lowresource	lowresource	PROPN
asodahs-128	298	12	settings	setting	NOUN
asodahs-128	298	13	where	where	SCONJ
asodahs-128	298	14	scd	scd	PROPN
asodahs-128	298	15	is	be	AUX
asodahs-128	298	16	prevalent	prevalent	ADJ
asodahs-128	298	17	37	37	NUM
asodahs-128	298	18	.	.	PUNCT
asodahs-128	299	1	conclusion	conclusion	NOUN
asodahs-128	299	2	nitrogen	nitrogen	NOUN
asodahs-128	299	3	balance	balance	NOUN
asodahs-128	299	4	is	be	AUX
asodahs-128	299	5	a	a	DET
asodahs-128	299	6	fundamental	fundamental	ADJ
asodahs-128	299	7	determinant	determinant	NOUN
asodahs-128	299	8	of	of	ADP
asodahs-128	299	9	hematological	hematological	ADJ
asodahs-128	299	10	stability	stability	NOUN
asodahs-128	299	11	and	and	CCONJ
asodahs-128	299	12	overall	overall	ADJ
asodahs-128	299	13	health	health	NOUN
asodahs-128	299	14	in	in	ADP
asodahs-128	299	15	individuals	individual	NOUN
asodahs-128	299	16	with	with	ADP
asodahs-128	299	17	sickle	sickle	NOUN
asodahs-128	299	18	cell	cell	NOUN
asodahs-128	299	19	disease	disease	NOUN
asodahs-128	299	20	(	(	PUNCT
asodahs-128	299	21	scd	scd	NOUN
asodahs-128	299	22	)	)	PUNCT
asodahs-128	299	23	.	.	PUNCT
asodahs-128	300	1	the	the	DET
asodahs-128	300	2	chronic	chronic	ADJ
asodahs-128	300	3	metabolic	metabolic	NOUN
asodahs-128	300	4	demands	demand	NOUN
asodahs-128	300	5	imposed	impose	VERB
asodahs-128	300	6	by	by	ADP
asodahs-128	300	7	hemolysis	hemolysis	NOUN
asodahs-128	300	8	,	,	PUNCT
asodahs-128	300	9	inflammation	inflammation	NOUN
asodahs-128	300	10	,	,	PUNCT
asodahs-128	300	11	and	and	CCONJ
asodahs-128	300	12	tissue	tissue	NOUN
asodahs-128	300	13	repair	repair	NOUN
asodahs-128	300	14	processes	process	NOUN
asodahs-128	300	15	render	render	VERB
asodahs-128	300	16	patients	patient	NOUN
asodahs-128	300	17	particularly	particularly	ADV
asodahs-128	300	18	vulnerable	vulnerable	ADJ
asodahs-128	300	19	to	to	ADP
asodahs-128	300	20	nitrogen	nitrogen	NOUN
asodahs-128	300	21	deficits	deficit	NOUN
asodahs-128	300	22	.	.	PUNCT
asodahs-128	301	1	when	when	SCONJ
asodahs-128	301	2	unaddressed	unaddresse	VERB
asodahs-128	301	3	,	,	PUNCT
asodahs-128	301	4	nitrogen	nitrogen	NOUN
asodahs-128	301	5	imbalance	imbalance	NOUN
asodahs-128	301	6	exacerbates	exacerbate	VERB
asodahs-128	301	7	anemia	anemia	NOUN
asodahs-128	301	8	,	,	PUNCT
asodahs-128	301	9	impairs	impair	VERB
asodahs-128	301	10	immune	immune	ADJ
asodahs-128	301	11	function	function	NOUN
asodahs-128	301	12	,	,	PUNCT
asodahs-128	301	13	delays	delay	VERB
asodahs-128	301	14	growth	growth	NOUN
asodahs-128	301	15	and	and	CCONJ
asodahs-128	301	16	development	development	NOUN
asodahs-128	301	17	,	,	PUNCT
asodahs-128	301	18	and	and	CCONJ
asodahs-128	301	19	diminishes	diminish	VERB
asodahs-128	301	20	the	the	DET
asodahs-128	301	21	body	body	NOUN
asodahs-128	301	22	's	's	PART
asodahs-128	301	23	capacity	capacity	NOUN
asodahs-128	301	24	to	to	PART
asodahs-128	301	25	withstand	withstand	VERB
asodahs-128	301	26	oxidative	oxidative	ADJ
asodahs-128	301	27	and	and	CCONJ
asodahs-128	301	28	infectious	infectious	ADJ
asodahs-128	301	29	stressors	stressor	NOUN
asodahs-128	301	30	.	.	PUNCT
asodahs-128	302	1	these	these	DET
asodahs-128	302	2	consequences	consequence	NOUN
asodahs-128	302	3	underscore	underscore	VERB
asodahs-128	302	4	the	the	DET
asodahs-128	302	5	importance	importance	NOUN
asodahs-128	302	6	of	of	ADP
asodahs-128	302	7	integrating	integrate	VERB
asodahs-128	302	8	nitrogen	nitrogen	NOUN
asodahs-128	302	9	balance	balance	NOUN
asodahs-128	302	10	assessment	assessment	NOUN
asodahs-128	302	11	and	and	CCONJ
asodahs-128	302	12	management	management	NOUN
asodahs-128	302	13	into	into	ADP
asodahs-128	302	14	the	the	DET
asodahs-128	302	15	comprehensive	comprehensive	ADJ
asodahs-128	302	16	care	care	NOUN
asodahs-128	302	17	of	of	ADP
asodahs-128	302	18	scd	scd	NOUN
asodahs-128	302	19	patients	patient	NOUN
asodahs-128	302	20	.	.	PUNCT
asodahs-128	303	1	nutritional	nutritional	ADJ
asodahs-128	303	2	strategies	strategy	NOUN
asodahs-128	303	3	,	,	PUNCT
asodahs-128	303	4	including	include	VERB
asodahs-128	303	5	increased	increase	VERB
asodahs-128	303	6	protein	protein	NOUN
asodahs-128	303	7	intake	intake	NOUN
asodahs-128	303	8	,	,	PUNCT
asodahs-128	303	9	targeted	target	VERB
asodahs-128	303	10	amino	amino	NOUN
asodahs-128	303	11	acid	acid	NOUN
asodahs-128	303	12	supplementation	supplementation	NOUN
asodahs-128	303	13	,	,	PUNCT
asodahs-128	303	14	and	and	CCONJ
asodahs-128	303	15	micronutrient	micronutrient	NOUN
asodahs-128	303	16	support	support	NOUN
asodahs-128	303	17	,	,	PUNCT
asodahs-128	303	18	can	can	AUX
asodahs-128	303	19	effectively	effectively	ADV
asodahs-128	303	20	restore	restore	VERB
asodahs-128	303	21	nitrogen	nitrogen	NOUN
asodahs-128	303	22	equilibrium	equilibrium	NOUN
asodahs-128	303	23	and	and	CCONJ
asodahs-128	303	24	enhance	enhance	VERB
asodahs-128	303	25	clinical	clinical	ADJ
asodahs-128	303	26	outcomes	outcome	NOUN
asodahs-128	303	27	.	.	PUNCT
asodahs-128	304	1	additionally	additionally	ADV
asodahs-128	304	2	,	,	PUNCT
asodahs-128	304	3	proactive	proactive	ADJ
asodahs-128	304	4	clinical	clinical	ADJ
asodahs-128	304	5	monitoring	monitoring	NOUN
asodahs-128	304	6	and	and	CCONJ
asodahs-128	304	7	individualized	individualized	ADJ
asodahs-128	304	8	dietary	dietary	ADJ
asodahs-128	304	9	planning	planning	NOUN
asodahs-128	304	10	are	be	AUX
asodahs-128	304	11	essential	essential	ADJ
asodahs-128	304	12	to	to	PART
asodahs-128	304	13	ensure	ensure	VERB
asodahs-128	304	14	that	that	SCONJ
asodahs-128	304	15	metabolic	metabolic	NOUN
asodahs-128	304	16	demands	demand	NOUN
asodahs-128	304	17	are	be	AUX
asodahs-128	304	18	met	meet	VERB
asodahs-128	304	19	across	across	ADP
asodahs-128	304	20	the	the	DET
asodahs-128	304	21	disease	disease	NOUN
asodahs-128	304	22	spectrum	spectrum	NOUN
asodahs-128	304	23	—	—	PUNCT
asodahs-128	304	24	from	from	ADP
asodahs-128	304	25	childhood	childhood	NOUN
asodahs-128	304	26	through	through	ADP
asodahs-128	304	27	adulthood	adulthood	NOUN
asodahs-128	304	28	,	,	PUNCT
asodahs-128	304	29	and	and	CCONJ
asodahs-128	304	30	during	during	ADP
asodahs-128	304	31	both	both	CCONJ
asodahs-128	304	32	steady	steady	ADJ
asodahs-128	304	33	-	-	PUNCT
asodahs-128	304	34	state	state	NOUN
asodahs-128	304	35	and	and	CCONJ
asodahs-128	304	36	crisis	crisis	NOUN
asodahs-128	304	37	periods	period	NOUN
asodahs-128	304	38	.	.	PUNCT
asodahs-128	305	1	conflict	conflict	NOUN
asodahs-128	305	2	of	of	ADP
asodahs-128	305	3	interest	interest	NOUN
asodahs-128	305	4	:	:	PUNCT
asodahs-128	305	5	author	author	NOUN
asodahs-128	305	6	declares	declare	VERB
asodahs-128	305	7	no	no	DET
asodahs-128	305	8	potential	potential	ADJ
asodahs-128	305	9	conflict	conflict	NOUN
asodahs-128	305	10	of	of	ADP
asodahs-128	305	11	interest	interest	NOUN
asodahs-128	305	12	with	with	ADP
asodahs-128	305	13	respect	respect	NOUN
asodahs-128	305	14	to	to	ADP
asodahs-128	305	15	the	the	DET
asodahs-128	305	16	contents	content	NOUN
asodahs-128	305	17	,	,	PUNCT
asodahs-128	305	18	authorship	authorship	NOUN
asodahs-128	305	19	,	,	PUNCT
asodahs-128	305	20	and/or	and/or	CCONJ
asodahs-128	305	21	publication	publication	NOUN
asodahs-128	305	22	of	of	ADP
asodahs-128	305	23	this	this	DET
asodahs-128	305	24	article	article	NOUN
asodahs-128	305	25	.	.	PUNCT
asodahs-128	306	1	source	source	NOUN
asodahs-128	306	2	of	of	ADP
asodahs-128	306	3	support	support	NOUN
asodahs-128	306	4	:	:	PUNCT
asodahs-128	306	5	nil	nil	NOUN
asodahs-128	306	6	funding	funding	NOUN
asodahs-128	306	7	:	:	PUNCT
asodahs-128	306	8	the	the	DET
asodahs-128	306	9	authors	author	NOUN
asodahs-128	306	10	declared	declare	VERB
asodahs-128	306	11	that	that	SCONJ
asodahs-128	306	12	this	this	DET
asodahs-128	306	13	study	study	NOUN
asodahs-128	306	14	has	have	AUX
asodahs-128	306	15	received	receive	VERB
asodahs-128	306	16	no	no	DET
asodahs-128	306	17	financial	financial	ADJ
asodahs-128	306	18	support	support	NOUN
asodahs-128	306	19	.	.	PUNCT
asodahs-128	307	1	informed	informed	ADJ
asodahs-128	307	2	consent	consent	NOUN
asodahs-128	307	3	statement	statement	NOUN
asodahs-128	307	4	:	:	PUNCT
asodahs-128	307	5	not	not	PART
asodahs-128	307	6	applicable	applicable	ADJ
asodahs-128	307	7	.	.	PUNCT
asodahs-128	308	1	data	datum	NOUN
asodahs-128	308	2	availability	availability	NOUN
asodahs-128	308	3	statement	statement	NOUN
asodahs-128	308	4	:	:	PUNCT
asodahs-128	308	5	the	the	DET
asodahs-128	308	6	data	datum	NOUN
asodahs-128	308	7	supporting	support	VERB
asodahs-128	308	8	in	in	ADP
asodahs-128	308	9	this	this	DET
asodahs-128	308	10	paper	paper	NOUN
asodahs-128	308	11	are	be	AUX
asodahs-128	308	12	available	available	ADJ
asodahs-128	308	13	in	in	ADP
asodahs-128	308	14	the	the	DET
asodahs-128	308	15	cited	cite	VERB
asodahs-128	308	16	references	reference	NOUN
asodahs-128	308	17	.	.	PUNCT
asodahs-128	309	1	ethics	ethic	NOUN
asodahs-128	309	2	approval	approval	NOUN
asodahs-128	309	3	:	:	PUNCT
asodahs-128	309	4	not	not	PART
asodahs-128	309	5	applicable	applicable	ADJ
asodahs-128	309	6	.	.	PUNCT
asodahs-128	310	1	references	reference	NOUN
asodahs-128	310	2	1	1	NUM
asodahs-128	310	3	.	.	PUNCT
asodahs-128	311	1	gupta	gupta	PROPN
asodahs-128	311	2	a.	a.	PROPN
asodahs-128	311	3	sickle	sickle	PROPN
asodahs-128	311	4	cell	cell	NOUN
asodahs-128	311	5	anemia	anemia	NOUN
asodahs-128	311	6	and	and	CCONJ
asodahs-128	311	7	related	related	ADJ
asodahs-128	311	8	hemoglobinopathies	hemoglobinopathy	NOUN
asodahs-128	311	9	.	.	PUNCT
asodahs-128	312	1	indecision	indecision	NOUN
asodahs-128	312	2	making	make	VERB
asodahs-128	312	3	through	through	ADP
asodahs-128	312	4	problem	problem	NOUN
asodahs-128	312	5	based	base	VERB
asodahs-128	312	6	learning	learn	VERB
asodahs-128	312	7	in	in	ADP
asodahs-128	312	8	hematology	hematology	NOUN
asodahs-128	312	9	:	:	PUNCT
asodahs-128	312	10	a	a	DET
asodahs-128	312	11	step	step	NOUN
asodahs-128	312	12	-	-	PUNCT
asodahs-128	312	13	by	by	ADP
asodahs-128	312	14	-	-	PUNCT
asodahs-128	312	15	step	step	NOUN
asodahs-128	312	16	approach	approach	NOUN
asodahs-128	312	17	in	in	ADP
asodahs-128	312	18	patients	patient	NOUN
asodahs-128	312	19	with	with	ADP
asodahs-128	312	20	anemia	anemia	NOUN
asodahs-128	312	21	2024	2024	NUM
asodahs-128	312	22	:	:	PUNCT
asodahs-128	312	23	269	269	NUM
asodahs-128	312	24	-	-	SYM
asodahs-128	312	25	289	289	NUM
asodahs-128	312	26	.	.	PUNCT
asodahs-128	313	1	singapore	singapore	PROPN
asodahs-128	313	2	:	:	PUNCT
asodahs-128	313	3	springer	springer	NOUN
asodahs-128	313	4	nature	nature	PROPN
asodahs-128	313	5	singapore	singapore	PROPN
asodahs-128	313	6	.	.	PUNCT
asodahs-128	314	1	https://doi.org/10.1007/978-981-99-8933-1_21	https://doi.org/10.1007/978-981-99-8933-1_21	PRON
asodahs-128	315	1	2	2	X
asodahs-128	315	2	.	.	PUNCT
asodahs-128	315	3	hassan	hassan	PROPN
asodahs-128	315	4	ms	ms	PROPN
asodahs-128	315	5	,	,	PUNCT
asodahs-128	315	6	nasrin	nasrin	PROPN
asodahs-128	315	7	t	t	PROPN
asodahs-128	315	8	,	,	PUNCT
asodahs-128	315	9	mahalka	mahalka	VERB
asodahs-128	315	10	a	a	PRON
asodahs-128	315	11	,	,	PUNCT
asodahs-128	315	12	hoque	hoque	NOUN
asodahs-128	315	13	m	m	PROPN
asodahs-128	315	14	,	,	PUNCT
asodahs-128	315	15	ali	ali	PROPN
asodahs-128	315	16	s.	s.	PROPN
asodahs-128	315	17	a	a	DET
asodahs-128	315	18	perspective	perspective	NOUN
asodahs-128	315	19	on	on	ADP
asodahs-128	315	20	the	the	DET
asodahs-128	315	21	genesis	genesis	NOUN
asodahs-128	315	22	,	,	PUNCT
asodahs-128	315	23	diagnostics	diagnostic	NOUN
asodahs-128	315	24	,	,	PUNCT
asodahs-128	315	25	and	and	CCONJ
asodahs-128	315	26	management	management	NOUN
asodahs-128	315	27	of	of	ADP
asodahs-128	315	28	sickle	sickle	NOUN
asodahs-128	315	29	cell	cell	NOUN
asodahs-128	315	30	disease	disease	NOUN
asodahs-128	315	31	.	.	PUNCT
asodahs-128	316	1	egyptian	egyptian	ADJ
asodahs-128	316	2	journal	journal	PROPN
asodahs-128	316	3	of	of	ADP
asodahs-128	316	4	medical	medical	ADJ
asodahs-128	316	5	human	human	ADJ
asodahs-128	316	6	genetics	genetic	NOUN
asodahs-128	316	7	.	.	PUNCT
asodahs-128	317	1	2024	2024	NUM
asodahs-128	317	2	;	;	PUNCT
asodahs-128	317	3	25(1):150	25(1):150	NUM
asodahs-128	317	4	.	.	PUNCT
asodahs-128	318	1	https://doi.org/10.1186/s43042-024-00623-1	https://doi.org/10.1186/s43042-024-00623-1	NUM
asodahs-128	318	2	3	3	NUM
asodahs-128	318	3	.	.	PUNCT
asodahs-128	319	1	rajput	rajput	PROPN
asodahs-128	319	2	hs	hs	PROPN
asodahs-128	319	3	,	,	PUNCT
asodahs-128	319	4	kumari	kumari	PROPN
asodahs-128	319	5	m	m	PROPN
asodahs-128	319	6	,	,	PUNCT
asodahs-128	319	7	talele	talele	PROPN
asodahs-128	319	8	c	c	X
asodahs-128	319	9	,	,	PUNCT
asodahs-128	319	10	sajan	sajan	PROPN
asodahs-128	319	11	c	c	PROPN
asodahs-128	319	12	,	,	PUNCT
asodahs-128	319	13	saggu	saggu	NOUN
asodahs-128	319	14	v	v	NOUN
asodahs-128	319	15	,	,	PUNCT
asodahs-128	319	16	hadia	hadia	PROPN
asodahs-128	319	17	r.	r.	PROPN
asodahs-128	319	18	comprehensive	comprehensive	PROPN
asodahs-128	319	19	overview	overview	NOUN
asodahs-128	319	20	of	of	ADP
asodahs-128	319	21	sickle	sickle	NOUN
asodahs-128	319	22	cell	cell	NOUN
asodahs-128	319	23	disease	disease	NOUN
asodahs-128	319	24	:	:	PUNCT
asodahs-128	319	25	global	global	ADJ
asodahs-128	319	26	impact	impact	NOUN
asodahs-128	319	27	,	,	PUNCT
asodahs-128	319	28	management	management	NOUN
asodahs-128	319	29	strategies	strategy	NOUN
asodahs-128	319	30	,	,	PUNCT
asodahs-128	319	31	and	and	CCONJ
asodahs-128	319	32	future	future	ADJ
asodahs-128	319	33	directions	direction	NOUN
asodahs-128	319	34	.	.	PUNCT
asodahs-128	320	1	journal	journal	NOUN
asodahs-128	320	2	of	of	ADP
asodahs-128	320	3	advanced	advanced	ADJ
asodahs-128	320	4	zoology	zoology	NOUN
asodahs-128	320	5	.	.	PUNCT
asodahs-128	321	1	2024	2024	NUM
asodahs-128	321	2	;	;	PUNCT
asodahs-128	321	3	45(1	45(1	NOUN
asodahs-128	321	4	)	)	PUNCT
asodahs-128	321	5	.	.	PUNCT
asodahs-128	322	1	https://doi.org/10.53555/jaz.v45i1.3390	https://doi.org/10.53555/jaz.v45i1.3390	PROPN
asodahs-128	322	2	4	4	X
asodahs-128	322	3	.	.	PUNCT
asodahs-128	322	4	obeagu	obeagu	PROPN
asodahs-128	322	5	ei	ei	PROPN
asodahs-128	322	6	.	.	PROPN
asodahs-128	322	7	role	role	NOUN
asodahs-128	322	8	of	of	ADP
asodahs-128	322	9	autophagy	autophagy	NOUN
asodahs-128	322	10	in	in	ADP
asodahs-128	322	11	modulating	modulate	VERB
asodahs-128	322	12	oxidative	oxidative	ADJ
asodahs-128	322	13	stress	stress	NOUN
asodahs-128	322	14	in	in	ADP
asodahs-128	322	15	sickle	sickle	NOUN
asodahs-128	322	16	cell	cell	NOUN
asodahs-128	322	17	disease	disease	NOUN
asodahs-128	322	18	:	:	PUNCT
asodahs-128	322	19	a	a	DET
asodahs-128	322	20	narrative	narrative	NOUN
asodahs-128	322	21	review	review	NOUN
asodahs-128	322	22	.	.	PUNCT
asodahs-128	323	1	int	int	NOUN
asodahs-128	323	2	.	.	PUNCT
asodahs-128	324	1	j.	j.	PROPN
asodahs-128	324	2	curr	curr	PROPN
asodahs-128	324	3	.	.	PUNCT
asodahs-128	325	1	res	res	PROPN
asodahs-128	325	2	.	.	PROPN
asodahs-128	325	3	chem	chem	PROPN
asodahs-128	325	4	.	.	PUNCT
asodahs-128	326	1	pharm	pharm	PROPN
asodahs-128	326	2	.	.	PUNCT
asodahs-128	327	1	sci	sci	PROPN
asodahs-128	327	2	.	.	PUNCT
asodahs-128	328	1	2024;11(8):38	2024;11(8):38	NUM
asodahs-128	328	2	-	-	SYM
asodahs-128	328	3	46	46	NUM
asodahs-128	328	4	.	.	PUNCT
asodahs-128	329	1	https://doi.org/10.23880/hij16000247	https://doi.org/10.23880/hij16000247	PROPN
asodahs-128	329	2	5	5	NUM
asodahs-128	329	3	.	.	PUNCT
asodahs-128	329	4	obeagu	obeagu	PROPN
asodahs-128	329	5	ei	ei	PROPN
asodahs-128	329	6	.	.	PUNCT
asodahs-128	330	1	redox	redox	ADJ
asodahs-128	330	2	regulation	regulation	NOUN
asodahs-128	330	3	of	of	ADP
asodahs-128	330	4	hemoglobin	hemoglobin	NOUN
asodahs-128	330	5	in	in	ADP
asodahs-128	330	6	sickle	sickle	NOUN
asodahs-128	330	7	cell	cell	NOUN
asodahs-128	330	8	disease	disease	NOUN
asodahs-128	330	9	:	:	PUNCT
asodahs-128	330	10	a	a	DET
asodahs-128	330	11	review	review	NOUN
asodahs-128	330	12	.	.	PUNCT
asodahs-128	331	1	int	int	NOUN
asodahs-128	331	2	.	.	PUNCT
asodahs-128	332	1	j.	j.	PROPN
asodahs-128	332	2	curr	curr	PROPN
asodahs-128	332	3	.	.	PUNCT
asodahs-128	333	1	res	res	PROPN
asodahs-128	333	2	.	.	PROPN
asodahs-128	333	3	chem	chem	PROPN
asodahs-128	333	4	.	.	PUNCT
asodahs-128	334	1	pharm	pharm	PROPN
asodahs-128	334	2	.	.	PUNCT
asodahs-128	335	1	sci	sci	PROPN
asodahs-128	335	2	.	.	PUNCT
asodahs-128	336	1	2024;11(8):13	2024;11(8):13	NUM
asodahs-128	336	2	-	-	SYM
asodahs-128	336	3	9	9	NUM
asodahs-128	336	4	.	.	NOUN
asodahs-128	336	5	6	6	NUM
asodahs-128	336	6	.	.	X
asodahs-128	336	7	obeagu	obeagu	PROPN
asodahs-128	336	8	ei	ei	PROPN
asodahs-128	336	9	,	,	PUNCT
asodahs-128	336	10	bunu	bunu	PROPN
asodahs-128	336	11	uo	uo	PROPN
asodahs-128	336	12	,	,	PUNCT
asodahs-128	336	13	obeagu	obeagu	PROPN
asodahs-128	336	14	gu	gu	PROPN
asodahs-128	336	15	,	,	PUNCT
asodahs-128	336	16	habimana	habimana	PROPN
asodahs-128	336	17	jb	jb	PROPN
asodahs-128	336	18	.	.	PUNCT
asodahs-128	337	1	antioxidants	antioxidant	NOUN
asodahs-128	337	2	in	in	ADP
asodahs-128	337	3	the	the	DET
asodahs-128	337	4	management	management	NOUN
asodahs-128	337	5	of	of	ADP
asodahs-128	337	6	sickle	sickle	PROPN
asodahs-128	337	7	cell	cell	NOUN
asodahs-128	337	8	anaemia	anaemia	NOUN
asodahs-128	337	9	:	:	PUNCT
asodahs-128	337	10	an	an	DET
asodahs-128	337	11	area	area	NOUN
asodahs-128	337	12	to	to	PART
asodahs-128	337	13	be	be	AUX
asodahs-128	337	14	exploited	exploit	VERB
asodahs-128	337	15	for	for	ADP
asodahs-128	337	16	the	the	DET
asodahs-128	337	17	wellbeing	wellbeing	NOUN
asodahs-128	337	18	of	of	ADP
asodahs-128	337	19	the	the	DET
asodahs-128	337	20	patients	patient	NOUN
asodahs-128	337	21	.	.	PUNCT
asodahs-128	338	1	int	int	NOUN
asodahs-128	338	2	res	re	NOUN
asodahs-128	338	3	med	med	PROPN
asodahs-128	338	4	health	health	PROPN
asodahs-128	338	5	sci	sci	PROPN
asodahs-128	338	6	.	.	PROPN
asodahs-128	338	7	2023	2023	NUM
asodahs-128	338	8	sep	sep	NOUN
asodahs-128	338	9	11;6:12	11;6:12	NUM
asodahs-128	338	10	-	-	SYM
asodahs-128	338	11	7	7	NUM
asodahs-128	338	12	.	.	NOUN
asodahs-128	338	13	7	7	NUM
asodahs-128	338	14	.	.	PUNCT
asodahs-128	338	15	xiao	xiao	PROPN
asodahs-128	338	16	r	r	PROPN
asodahs-128	338	17	,	,	PUNCT
asodahs-128	338	18	li	li	PROPN
asodahs-128	338	19	l	l	PROPN
asodahs-128	338	20	,	,	PUNCT
asodahs-128	338	21	zhang	zhang	PROPN
asodahs-128	338	22	y	y	PROPN
asodahs-128	338	23	,	,	PUNCT
asodahs-128	338	24	fang	fang	PROPN
asodahs-128	338	25	l	l	PROPN
asodahs-128	338	26	,	,	PUNCT
asodahs-128	338	27	li	li	PROPN
asodahs-128	338	28	r	r	PROPN
asodahs-128	338	29	,	,	PUNCT
asodahs-128	338	30	song	song	NOUN
asodahs-128	338	31	d	d	PROPN
asodahs-128	338	32	,	,	PUNCT
asodahs-128	338	33	liang	liang	PROPN
asodahs-128	338	34	t	t	PROPN
asodahs-128	338	35	,	,	PUNCT
asodahs-128	338	36	su	su	PROPN
asodahs-128	338	37	x.	x.	NOUN
asodahs-128	338	38	reducing	reduce	VERB
asodahs-128	338	39	carbon	carbon	NOUN
asodahs-128	338	40	and	and	CCONJ
asodahs-128	338	41	nitrogen	nitrogen	NOUN
asodahs-128	338	42	loss	loss	NOUN
asodahs-128	338	43	by	by	ADP
asodahs-128	338	44	shortening	shorten	VERB
asodahs-128	338	45	the	the	DET
asodahs-128	338	46	composting	compost	VERB
asodahs-128	338	47	duration	duration	NOUN
asodahs-128	338	48	based	base	VERB
asodahs-128	338	49	on	on	ADP
asodahs-128	338	50	seed	seed	NOUN
asodahs-128	338	51	germination	germination	NOUN
asodahs-128	338	52	index	index	NOUN
asodahs-128	338	53	(	(	PUNCT
asodahs-128	338	54	scd@	scd@	PROPN
asodahs-128	338	55	gi	gi	PROPN
asodahs-128	338	56	):	):	PUNCT
asodahs-128	338	57	feasibilities	feasibility	NOUN
asodahs-128	338	58	and	and	CCONJ
asodahs-128	338	59	challenges	challenge	NOUN
asodahs-128	338	60	.	.	PUNCT
asodahs-128	339	1	science	science	NOUN
asodahs-128	339	2	of	of	ADP
asodahs-128	339	3	the	the	DET
asodahs-128	339	4	total	total	ADJ
asodahs-128	339	5	environment	environment	NOUN
asodahs-128	339	6	.	.	PUNCT
asodahs-128	340	1	2024:172883	2024:172883	NUM
asodahs-128	340	2	.	.	PUNCT
asodahs-128	341	1	https://doi.org/10.1016/j.scitotenv.2024.172883	https://doi.org/10.1016/j.scitotenv.2024.172883	NOUN
asodahs-128	341	2	pmid:38697528	pmid:38697528	NOUN
asodahs-128	341	3	8	8	NUM
asodahs-128	341	4	.	.	PUNCT
asodahs-128	342	1	lin	lin	PROPN
asodahs-128	342	2	w	w	PROPN
asodahs-128	342	3	,	,	PUNCT
asodahs-128	342	4	lv	lv	PROPN
asodahs-128	342	5	x	x	PROPN
asodahs-128	342	6	,	,	PUNCT
asodahs-128	342	7	wang	wang	PROPN
asodahs-128	342	8	q	q	PROPN
asodahs-128	342	9	,	,	PUNCT
asodahs-128	342	10	li	li	PROPN
asodahs-128	342	11	l	l	PROPN
asodahs-128	342	12	,	,	PUNCT
asodahs-128	342	13	zou	zou	PROPN
asodahs-128	342	14	g.	g.	PROPN
asodahs-128	342	15	nitrogen	nitrogen	PROPN
asodahs-128	342	16	concentration	concentration	NOUN
asodahs-128	342	17	dependent	dependent	ADJ
asodahs-128	342	18	optical	optical	ADJ
asodahs-128	342	19	defects	defect	NOUN
asodahs-128	342	20	transition	transition	NOUN
asodahs-128	342	21	in	in	ADP
asodahs-128	342	22	single	single	ADJ
asodahs-128	342	23	crystal	crystal	NOUN
asodahs-128	342	24	diamond	diamond	NOUN
asodahs-128	342	25	through	through	ADP
asodahs-128	342	26	low	low	ADJ
asodahs-128	342	27	pressure	pressure	NOUN
asodahs-128	342	28	high	high	ADJ
asodahs-128	342	29	temperature	temperature	NOUN
asodahs-128	342	30	annealing	annealing	NOUN
asodahs-128	342	31	.	.	PUNCT
asodahs-128	343	1	vacuum	vacuum	NOUN
asodahs-128	343	2	.	.	PUNCT
asodahs-128	344	1	2025:114329	2025:114329	X
asodahs-128	344	2	.	.	PUNCT
asodahs-128	345	1	https://doi.org/10.1016/j.vacuum.2025.114329	https://doi.org/10.1016/j.vacuum.2025.114329	ADJ
asodahs-128	345	2	9	9	NUM
asodahs-128	345	3	.	.	PUNCT
asodahs-128	345	4	wood	wood	NOUN
asodahs-128	345	5	kc	kc	PROPN
asodahs-128	345	6	,	,	PUNCT
asodahs-128	345	7	granger	granger	PROPN
asodahs-128	345	8	dn	dn	PROPN
asodahs-128	345	9	.	.	PROPN
asodahs-128	345	10	sickle	sickle	PROPN
asodahs-128	345	11	cell	cell	NOUN
asodahs-128	345	12	disease	disease	NOUN
asodahs-128	345	13	:	:	PUNCT
asodahs-128	345	14	role	role	NOUN
asodahs-128	345	15	of	of	ADP
asodahs-128	345	16	reactive	reactive	ADJ
asodahs-128	345	17	oxygen	oxygen	NOUN
asodahs-128	345	18	and	and	CCONJ
asodahs-128	345	19	nitrogen	nitrogen	NOUN
asodahs-128	345	20	metabolites	metabolite	NOUN
asodahs-128	345	21	.	.	PUNCT
asodahs-128	346	1	clinical	clinical	ADJ
asodahs-128	346	2	&	&	CCONJ
asodahs-128	346	3	experimental	experimental	ADJ
asodahs-128	346	4	pharmacology	pharmacology	NOUN
asodahs-128	346	5	&	&	CCONJ
asodahs-128	346	6	physiology	physiology	NOUN
asodahs-128	346	7	.	.	PUNCT
asodahs-128	347	1	2007	2007	NUM
asodahs-128	347	2	sep	sep	NOUN
asodahs-128	347	3	1;34(9	1;34(9	NOUN
asodahs-128	347	4	)	)	PUNCT
asodahs-128	347	5	.	.	PUNCT
asodahs-128	348	1	https://doi.org/10.1111/j.14401681.2007.04639.x	https://doi.org/10.1111/j.14401681.2007.04639.x	X
asodahs-128	348	2	pmid:17645642	pmid:17645642	VERB
asodahs-128	348	3	10	10	NUM
asodahs-128	348	4	.	.	PUNCT
asodahs-128	349	1	dijkmans	dijkmans	PROPN
asodahs-128	349	2	t	t	PROPN
asodahs-128	349	3	,	,	PUNCT
asodahs-128	349	4	djokic	djokic	PROPN
asodahs-128	349	5	mr	mr	PROPN
asodahs-128	349	6	,	,	PUNCT
asodahs-128	349	7	van	van	PROPN
asodahs-128	349	8	geem	geem	PROPN
asodahs-128	349	9	km	km	PROPN
asodahs-128	349	10	,	,	PUNCT
asodahs-128	349	11	marin	marin	NOUN
asodahs-128	349	12	gb	gb	PROPN
asodahs-128	349	13	.	.	PUNCT
asodahs-128	350	1	comprehensive	comprehensive	ADJ
asodahs-128	350	2	compositional	compositional	ADJ
asodahs-128	350	3	analysis	analysis	NOUN
asodahs-128	350	4	of	of	ADP
asodahs-128	350	5	sulfur	sulfur	NOUN
asodahs-128	350	6	and	and	CCONJ
asodahs-128	350	7	nitrogen	nitrogen	NOUN
asodahs-128	350	8	containing	contain	VERB
asodahs-128	350	9	compounds	compound	NOUN
asodahs-128	350	10	in	in	ADP
asodahs-128	350	11	shale	shale	NOUN
asodahs-128	350	12	oil	oil	NOUN
asodahs-128	350	13	using	use	VERB
asodahs-128	350	14	gc×	gc×	PROPN
asodahs-128	350	15	gc	gc	PROPN
asodahs-128	350	16	-	-	PUNCT
asodahs-128	350	17	fid	fid	NOUN
asodahs-128	350	18	/	/	SYM
asodahs-128	350	19	scd	scd	NOUN
asodahs-128	350	20	/	/	SYM
asodahs-128	350	21	ncd	ncd	PROPN
asodahs-128	350	22	/	/	SYM
asodahs-128	350	23	tof	tof	PROPN
asodahs-128	350	24	-	-	PUNCT
asodahs-128	350	25	ms	ms	PROPN
asodahs-128	350	26	.	.	PROPN
asodahs-128	350	27	fuel	fuel	NOUN
asodahs-128	350	28	.	.	PUNCT
asodahs-128	351	1	2015	2015	NUM
asodahs-128	351	2	;	;	PUNCT
asodahs-128	352	1	140:398	140:398	NUM
asodahs-128	352	2	-	-	PUNCT
asodahs-128	352	3	406	406	NUM
asodahs-128	352	4	.	.	PUNCT
asodahs-128	353	1	https://doi.org/10.1016/j.fuel.2014.09.055	https://doi.org/10.1016/j.fuel.2014.09.055	VERB
asodahs-128	353	2	11	11	NUM
asodahs-128	353	3	.	.	PUNCT
asodahs-128	354	1	muehle	muehle	PROPN
asodahs-128	354	2	m	m	PROPN
asodahs-128	354	3	,	,	PUNCT
asodahs-128	354	4	asmussen	asmussen	PROPN
asodahs-128	354	5	j	j	PROPN
asodahs-128	354	6	,	,	PUNCT
asodahs-128	354	7	becker	becker	PROPN
asodahs-128	354	8	mf	mf	VERB
asodahs-128	354	9	,	,	PUNCT
asodahs-128	354	10	schuelke	schuelke	ADJ
asodahs-128	354	11	t.	t.	NOUN
asodahs-128	354	12	extending	extend	VERB
asodahs-128	354	13	microwave	microwave	NOUN
asodahs-128	354	14	plasma	plasma	NOUN
asodahs-128	354	15	assisted	assist	VERB
asodahs-128	354	16	cvd	cvd	PROPN
asodahs-128	354	17	scd	scd	PROPN
asodahs-128	354	18	growth	growth	NOUN
asodahs-128	354	19	to	to	ADP
asodahs-128	354	20	pressures	pressure	NOUN
asodahs-128	354	21	of	of	ADP
asodahs-128	354	22	400	400	NUM
asodahs-128	354	23	torr	torr	NOUN
asodahs-128	354	24	.	.	PUNCT
asodahs-128	355	1	diamond	diamond	PROPN
asodahs-128	355	2	and	and	CCONJ
asodahs-128	355	3	related	related	ADJ
asodahs-128	355	4	materials	material	NOUN
asodahs-128	355	5	.	.	PUNCT
asodahs-128	355	6	2017	2017	NUM
asodahs-128	355	7	;	;	PUNCT
asodahs-128	355	8	79:150	79:150	NUM
asodahs-128	355	9	-	-	SYM
asodahs-128	355	10	163	163	NUM
asodahs-128	355	11	.	.	PUNCT
asodahs-128	356	1	https://doi.org/10.1016/j.diamond.2017.09.013	https://doi.org/10.1016/j.diamond.2017.09.013	PROPN
asodahs-128	356	2	12	12	NUM
asodahs-128	356	3	.	.	PUNCT
asodahs-128	357	1	obeagu	obeagu	PROPN
asodahs-128	357	2	ei	ei	PROPN
asodahs-128	357	3	,	,	PUNCT
asodahs-128	357	4	obeagu	obeagu	PROPN
asodahs-128	357	5	gu	gu	PROPN
asodahs-128	357	6	.	.	PUNCT
asodahs-128	357	7	immunization	immunization	NOUN
asodahs-128	357	8	strategies	strategy	NOUN
asodahs-128	357	9	for	for	ADP
asodahs-128	357	10	individuals	individual	NOUN
asodahs-128	357	11	with	with	ADP
asodahs-128	357	12	sickle	sickle	NOUN
asodahs-128	357	13	cell	cell	NOUN
asodahs-128	357	14	anemia	anemia	NOUN
asodahs-128	357	15	:	:	PUNCT
asodahs-128	357	16	a	a	DET
asodahs-128	357	17	narrative	narrative	NOUN
asodahs-128	357	18	review	review	NOUN
asodahs-128	357	19	.	.	PUNCT
asodahs-128	358	1	medicine	medicine	NOUN
asodahs-128	358	2	.	.	PUNCT
asodahs-128	359	1	2024	2024	NUM
asodahs-128	359	2	;	;	PUNCT
asodahs-128	359	3	103(38):e39756	103(38):e39756	NUM
asodahs-128	359	4	.	.	PUNCT
asodahs-128	360	1	https://doi.org/10.1097/md.0000000000039756	https://doi.org/10.1097/md.0000000000039756	PROPN
asodahs-128	360	2	pmid:39312357	pmid:39312357	ADV
asodahs-128	360	3	pmcid	pmcid	NOUN
asodahs-128	360	4	:	:	PUNCT
asodahs-128	360	5	pmc11419550	pmc11419550	NOUN
asodahs-128	360	6	13	13	NUM
asodahs-128	360	7	.	.	PUNCT
asodahs-128	361	1	obeagu	obeagu	PROPN
asodahs-128	361	2	ei	ei	PROPN
asodahs-128	361	3	.	.	PUNCT
asodahs-128	361	4	strategies	strategy	NOUN
asodahs-128	361	5	for	for	ADP
asodahs-128	361	6	reducing	reduce	VERB
asodahs-128	361	7	child	child	NOUN
asodahs-128	361	8	mortality	mortality	NOUN
asodahs-128	361	9	due	due	ADP
asodahs-128	361	10	to	to	ADP
asodahs-128	361	11	sickle	sickle	VERB
asodahs-128	361	12	cell	cell	NOUN
asodahs-128	361	13	disease	disease	NOUN
asodahs-128	361	14	in	in	ADP
asodahs-128	361	15	uganda	uganda	PROPN
asodahs-128	361	16	:	:	PUNCT
asodahs-128	361	17	a	a	DET
asodahs-128	361	18	narrative	narrative	NOUN
asodahs-128	361	19	review	review	NOUN
asodahs-128	361	20	.	.	PUNCT
asodahs-128	362	1	annals	annal	NOUN
asodahs-128	362	2	of	of	ADP
asodahs-128	362	3	medicine	medicine	NOUN
asodahs-128	362	4	and	and	CCONJ
asodahs-128	362	5	surgery.:10	surgery.:10	NOUN
asodahs-128	362	6	-	-	PUNCT
asodahs-128	362	7	97	97	NUM
asodahs-128	362	8	.	.	PUNCT
asodahs-128	363	1	14	14	NUM
asodahs-128	363	2	.	.	PUNCT
asodahs-128	364	1	obeagu	obeagu	PROPN
asodahs-128	364	2	ei	ei	PROPN
asodahs-128	364	3	.	.	PROPN
asodahs-128	364	4	erythropoeitin	erythropoeitin	PROPN
asodahs-128	364	5	in	in	ADP
asodahs-128	364	6	sickle	sickle	NOUN
asodahs-128	364	7	cell	cell	NOUN
asodahs-128	364	8	anaemia	anaemia	NOUN
asodahs-128	364	9	:	:	PUNCT
asodahs-128	364	10	a	a	DET
asodahs-128	364	11	review	review	NOUN
asodahs-128	364	12	.	.	PUNCT
asodahs-128	365	1	international	international	ADJ
asodahs-128	365	2	journal	journal	PROPN
asodahs-128	365	3	of	of	ADP
asodahs-128	365	4	research	research	NOUN
asodahs-128	365	5	studies	study	NOUN
asodahs-128	365	6	in	in	ADP
asodahs-128	365	7	medical	medical	ADJ
asodahs-128	365	8	and	and	CCONJ
asodahs-128	365	9	health	health	NOUN
asodahs-128	365	10	sciences	science	NOUN
asodahs-128	365	11	.	.	PUNCT
asodahs-128	366	1	2020;5(2):22	2020;5(2):22	NUM
asodahs-128	366	2	-	-	SYM
asodahs-128	366	3	8	8	NUM
asodahs-128	366	4	.	.	PUNCT
asodahs-128	367	1	https://doi.org/10.22259/ijrsmhs.0502004	https://doi.org/10.22259/ijrsmhs.0502004	VERB
asodahs-128	367	2	15	15	NUM
asodahs-128	367	3	.	.	PUNCT
asodahs-128	368	1	obeagu	obeagu	PROPN
asodahs-128	368	2	ei	ei	PROPN
asodahs-128	368	3	,	,	PUNCT
asodahs-128	368	4	obeagu	obeagu	PROPN
asodahs-128	368	5	gu	gu	PROPN
asodahs-128	368	6	.	.	PROPN
asodahs-128	368	7	malnutrition	malnutrition	NOUN
asodahs-128	368	8	in	in	ADP
asodahs-128	368	9	sickle	sickle	PROPN
asodahs-128	368	10	cell	cell	NOUN
asodahs-128	368	11	anemia	anemia	NOUN
asodahs-128	368	12	:	:	PUNCT
asodahs-128	368	13	prevalence	prevalence	NOUN
asodahs-128	368	14	,	,	PUNCT
asodahs-128	368	15	impact	impact	NOUN
asodahs-128	368	16	,	,	PUNCT
asodahs-128	368	17	and	and	CCONJ
asodahs-128	368	18	interventions	intervention	NOUN
asodahs-128	368	19	:	:	PUNCT
asodahs-128	368	20	a	a	DET
asodahs-128	368	21	review	review	NOUN
asodahs-128	368	22	.	.	PUNCT
asodahs-128	369	1	medicine	medicine	NOUN
asodahs-128	369	2	.	.	PUNCT
asodahs-128	370	1	2024	2024	NUM
asodahs-128	370	2	may	may	AUX
asodahs-128	370	3	17;103(20):e38164	17;103(20):e38164	NUM
asodahs-128	370	4	.	.	PUNCT
asodahs-128	371	1	https://doi.org/10.1097/md.0000000000038164	https://doi.org/10.1097/md.0000000000038164	PUNCT
asodahs-128	371	2	pmid:38758879	pmid:38758879	ADJ
asodahs-128	371	3	pmcid	pmcid	NOUN
asodahs-128	371	4	:	:	PUNCT
asodahs-128	371	5	pmc11098235	pmc11098235	VERB
asodahs-128	371	6	16	16	NUM
asodahs-128	371	7	.	.	PUNCT
asodahs-128	372	1	quemada	quemada	PROPN
asodahs-128	372	2	m	m	PROPN
asodahs-128	372	3	,	,	PUNCT
asodahs-128	372	4	delgado	delgado	VERB
asodahs-128	372	5	a	a	PRON
asodahs-128	372	6	,	,	PUNCT
asodahs-128	372	7	mateos	mateos	PROPN
asodahs-128	372	8	l	l	PROPN
asodahs-128	372	9	,	,	PUNCT
asodahs-128	372	10	villalobos	villalobos	PROPN
asodahs-128	372	11	fj	fj	PROPN
asodahs-128	372	12	.	.	PUNCT
asodahs-128	373	1	nitrogen	nitrogen	PROPN
asodahs-128	373	2	fertilization	fertilization	NOUN
asodahs-128	373	3	i	i	PRON
asodahs-128	373	4	:	:	PUNCT
asodahs-128	373	5	the	the	DET
asodahs-128	373	6	nitrogen	nitrogen	NOUN
asodahs-128	373	7	balance	balance	NOUN
asodahs-128	373	8	.	.	PUNCT
asodahs-128	374	1	inprinciples	inprinciple	NOUN
asodahs-128	374	2	of	of	ADP
asodahs-128	374	3	agronomy	agronomy	NOUN
asodahs-128	374	4	for	for	ADP
asodahs-128	374	5	sustainable	sustainable	ADJ
asodahs-128	374	6	agriculture	agriculture	NOUN
asodahs-128	374	7	2024	2024	NUM
asodahs-128	374	8	:	:	PUNCT
asodahs-128	374	9	377	377	NUM
asodahs-128	374	10	-	-	SYM
asodahs-128	374	11	401	401	NUM
asodahs-128	374	12	.	.	PUNCT
asodahs-128	375	1	cham	cham	PROPN
asodahs-128	375	2	:	:	PUNCT
asodahs-128	375	3	springer	springer	NOUN
asodahs-128	375	4	international	international	ADJ
asodahs-128	375	5	publishing	publishing	NOUN
asodahs-128	375	6	.	.	PUNCT
asodahs-128	376	1	https://doi.org/10.1007/978-3-03169150-8_26	https://doi.org/10.1007/978-3-03169150-8_26	PROPN
asodahs-128	376	2	17	17	NUM
asodahs-128	376	3	.	.	PUNCT
asodahs-128	377	1	krug	krug	PROPN
asodahs-128	377	2	ec	ec	PROPN
asodahs-128	377	3	,	,	PUNCT
asodahs-128	377	4	winstanley	winstanley	PROPN
asodahs-128	377	5	d.	d.	PROPN
asodahs-128	377	6	the	the	DET
asodahs-128	377	7	need	need	NOUN
asodahs-128	377	8	for	for	ADP
asodahs-128	377	9	comprehensive	comprehensive	ADJ
asodahs-128	377	10	and	and	CCONJ
asodahs-128	377	11	consistent	consistent	ADJ
asodahs-128	377	12	treatment	treatment	NOUN
asodahs-128	377	13	of	of	ADP
asodahs-128	377	14	the	the	DET
asodahs-128	377	15	nitrogen	nitrogen	NOUN
asodahs-128	377	16	cycle	cycle	NOUN
asodahs-128	377	17	in	in	ADP
asodahs-128	377	18	nitrogen	nitrogen	NOUN
asodahs-128	377	19	cycling	cycling	NOUN
asodahs-128	377	20	and	and	CCONJ
asodahs-128	377	21	mass	mass	NOUN
asodahs-128	377	22	balance	balance	NOUN
asodahs-128	377	23	studies	study	NOUN
asodahs-128	377	24	:	:	PUNCT
asodahs-128	377	25	i.	i.	PROPN
asodahs-128	377	26	terrestrial	terrestrial	PROPN
asodahs-128	377	27	nitrogen	nitrogen	NOUN
asodahs-128	377	28	cycle	cycle	NOUN
asodahs-128	377	29	.	.	PUNCT
asodahs-128	378	1	science	science	NOUN
asodahs-128	378	2	of	of	ADP
asodahs-128	378	3	the	the	DET
asodahs-128	378	4	total	total	ADJ
asodahs-128	378	5	environment	environment	NOUN
asodahs-128	378	6	.	.	PUNCT
asodahs-128	379	1	2002	2002	NUM
asodahs-128	379	2	;	;	PUNCT
asodahs-128	379	3	293(1	293(1	NUM
asodahs-128	379	4	-	-	SYM
asodahs-128	379	5	3):1	3):1	NUM
asodahs-128	379	6	-	-	SYM
asodahs-128	379	7	29	29	NUM
asodahs-128	379	8	.	.	PUNCT
asodahs-128	380	1	https://doi.org/10.1016/s0048-9697(01)01133-0	https://doi.org/10.1016/s0048-9697(01)01133-0	PROPN
asodahs-128	380	2	pmid:12109464	pmid:12109464	ADP
asodahs-128	380	3	18	18	NUM
asodahs-128	380	4	.	.	PUNCT
asodahs-128	381	1	zhang	zhang	PROPN
asodahs-128	381	2	cc	cc	PROPN
asodahs-128	381	3	,	,	PUNCT
asodahs-128	381	4	zhou	zhou	PROPN
asodahs-128	381	5	cz	cz	PROPN
asodahs-128	381	6	,	,	PUNCT
asodahs-128	381	7	burnap	burnap	PROPN
asodahs-128	381	8	rl	rl	PROPN
asodahs-128	381	9	,	,	PUNCT
asodahs-128	381	10	peng	peng	PROPN
asodahs-128	381	11	l.	l.	PROPN
asodahs-128	381	12	carbon	carbon	PROPN
asodahs-128	381	13	/	/	SYM
asodahs-128	381	14	nitrogen	nitrogen	NOUN
asodahs-128	381	15	metabolic	metabolic	NOUN
asodahs-128	381	16	balance	balance	NOUN
asodahs-128	381	17	:	:	PUNCT
asodahs-128	381	18	lessons	lesson	NOUN
asodahs-128	381	19	from	from	ADP
asodahs-128	381	20	cyanobacteria	cyanobacteria	NOUN
asodahs-128	381	21	.	.	PUNCT
asodahs-128	382	1	trends	trend	NOUN
asodahs-128	382	2	in	in	ADP
asodahs-128	382	3	plant	plant	NOUN
asodahs-128	382	4	science	science	NOUN
asodahs-128	382	5	.	.	PUNCT
asodahs-128	383	1	2018	2018	NUM
asodahs-128	383	2	;	;	PUNCT
asodahs-128	383	3	23(12):1116	23(12):1116	NUM
asodahs-128	383	4	-	-	SYM
asodahs-128	383	5	1130	1130	NUM
asodahs-128	383	6	.	.	PUNCT
asodahs-128	384	1	https://doi.org/10.1016/j.tplants.2018.09.008	https://doi.org/10.1016/j.tplants.2018.09.008	NOUN
asodahs-128	384	2	pmid:30292707	pmid:30292707	VERB
asodahs-128	384	3	19	19	NUM
asodahs-128	384	4	.	.	PUNCT
asodahs-128	385	1	enwonwu	enwonwu	PROPN
asodahs-128	385	2	co	co	PROPN
asodahs-128	385	3	,	,	PUNCT
asodahs-128	385	4	xu	xu	PROPN
asodahs-128	385	5	xx	xx	PROPN
asodahs-128	385	6	,	,	PUNCT
asodahs-128	385	7	turner	turner	PROPN
asodahs-128	385	8	e.	e.	PROPN
asodahs-128	385	9	nitrogen	nitrogen	PROPN
asodahs-128	385	10	metabolism	metabolism	NOUN
asodahs-128	385	11	in	in	ADP
asodahs-128	385	12	sickle	sickle	NOUN
asodahs-128	385	13	cell	cell	NOUN
asodahs-128	385	14	anemia	anemia	NOUN
asodahs-128	385	15	:	:	PUNCT
asodahs-128	385	16	free	free	ADJ
asodahs-128	385	17	amino	amino	NOUN
asodahs-128	385	18	acids	acid	NOUN
asodahs-128	385	19	in	in	ADP
asodahs-128	385	20	plasma	plasma	NOUN
asodahs-128	385	21	and	and	CCONJ
asodahs-128	385	22	urine	urine	NOUN
asodahs-128	385	23	.	.	PUNCT
asodahs-128	386	1	the	the	DET
asodahs-128	386	2	american	american	PROPN
asodahs-128	386	3	journal	journal	PROPN
asodahs-128	386	4	of	of	ADP
asodahs-128	386	5	the	the	DET
asodahs-128	386	6	medical	medical	ADJ
asodahs-128	386	7	sciences	science	NOUN
asodahs-128	386	8	.	.	PUNCT
asodahs-128	386	9	1990	1990	NUM
asodahs-128	386	10	;	;	PUNCT
asodahs-128	386	11	300(6):366	300(6):366	NUM
asodahs-128	386	12	-	-	SYM
asodahs-128	386	13	371	371	NUM
asodahs-128	386	14	.	.	PUNCT
asodahs-128	386	15	https://doi.org/10.1097/00000441-199012000-00005	https://doi.org/10.1097/00000441-199012000-00005	VERB
asodahs-128	386	16	pmid:2264574	pmid:2264574	NOUN
asodahs-128	386	17	20	20	NUM
asodahs-128	386	18	.	.	PUNCT
asodahs-128	387	1	borel	borel	PROPN
asodahs-128	387	2	mj	mj	PROPN
asodahs-128	387	3	,	,	PUNCT
asodahs-128	387	4	buchowski	buchowski	PROPN
asodahs-128	387	5	ms	ms	PROPN
asodahs-128	387	6	,	,	PUNCT
asodahs-128	387	7	turner	turner	PROPN
asodahs-128	387	8	ea	ea	PROPN
asodahs-128	387	9	,	,	PUNCT
asodahs-128	387	10	peeler	peeler	NOUN
asodahs-128	387	11	bb	bb	PROPN
asodahs-128	387	12	,	,	PUNCT
asodahs-128	387	13	goldstein	goldstein	PROPN
asodahs-128	387	14	re	re	PROPN
asodahs-128	387	15	,	,	PUNCT
asodahs-128	387	16	flakoll	flakoll	VERB
asodahs-128	388	1	pj	pj	PROPN
asodahs-128	388	2	.	.	PUNCT
asodahs-128	388	3	alterations	alteration	NOUN
asodahs-128	388	4	in	in	ADP
asodahs-128	388	5	basal	basal	ADJ
asodahs-128	388	6	nutrient	nutrient	NOUN
asodahs-128	388	7	metabolism	metabolism	NOUN
asodahs-128	388	8	increase	increase	NOUN
asodahs-128	388	9	resting	rest	VERB
asodahs-128	388	10	energy	energy	NOUN
asodahs-128	388	11	expenditure	expenditure	NOUN
asodahs-128	388	12	in	in	ADP
asodahs-128	388	13	sickle	sickle	NOUN
asodahs-128	388	14	cell	cell	NOUN
asodahs-128	388	15	disease	disease	NOUN
asodahs-128	388	16	.	.	PUNCT
asodahs-128	389	1	american	american	PROPN
asodahs-128	389	2	journal	journal	PROPN
asodahs-128	389	3	of	of	ADP
asodahs-128	389	4	physiology	physiology	NOUN
asodahs-128	389	5	-	-	PUNCT
asodahs-128	389	6	endocrinology	endocrinology	NOUN
asodahs-128	389	7	and	and	CCONJ
asodahs-128	389	8	metabolism	metabolism	NOUN
asodahs-128	389	9	.	.	PUNCT
asodahs-128	390	1	1998	1998	NUM
asodahs-128	390	2	;	;	PUNCT
asodahs-128	391	1	274(2):e357364	274(2):e357364	NUM
asodahs-128	391	2	.	.	PUNCT
asodahs-128	392	1	https://doi.org/10.1152/ajpendo.1998.274.2.e357	https://doi.org/10.1152/ajpendo.1998.274.2.e357	PROPN
asodahs-128	392	2	pmid:9486169	pmid:9486169	PROPN
asodahs-128	392	3	https://doi.org/10.1007/978-981-99-8933-1_21	https://doi.org/10.1007/978-981-99-8933-1_21	PRON
asodahs-128	392	4	https://doi.org/10.1186/s43042-024-00623-1	https://doi.org/10.1186/s43042-024-00623-1	NUM
asodahs-128	392	5	https://doi.org/10.53555/jaz.v45i1.3390	https://doi.org/10.53555/jaz.v45i1.3390	PROPN
asodahs-128	392	6	https://doi.org/10.23880/hij-16000247	https://doi.org/10.23880/hij-16000247	PROPN
asodahs-128	392	7	https://doi.org/10.23880/hij-16000247	https://doi.org/10.23880/hij-16000247	PROPN
asodahs-128	392	8	https://doi.org/10.1016/j.scitotenv.2024.172883	https://doi.org/10.1016/j.scitotenv.2024.172883	NOUN
asodahs-128	392	9	https://doi.org/10.1016/j.vacuum.2025.114329	https://doi.org/10.1016/j.vacuum.2025.114329	PROPN
asodahs-128	392	10	https://doi.org/10.1111/j.1440-1681.2007.04639.x	https://doi.org/10.1111/j.1440-1681.2007.04639.x	PROPN
asodahs-128	393	1	https://doi.org/10.1111/j.1440-1681.2007.04639.x	https://doi.org/10.1111/j.1440-1681.2007.04639.x	PROPN
asodahs-128	393	2	https://doi.org/10.1016/j.fuel.2014.09.055	https://doi.org/10.1016/j.fuel.2014.09.055	PROPN
asodahs-128	393	3	https://doi.org/10.1016/j.diamond.2017.09.013	https://doi.org/10.1016/j.diamond.2017.09.013	PROPN
asodahs-128	393	4	https://doi.org/10.1097/md.0000000000039756	https://doi.org/10.1097/md.0000000000039756	PROPN
asodahs-128	393	5	https://doi.org/10.22259/ijrsmhs.0502004	https://doi.org/10.22259/ijrsmhs.0502004	NOUN
asodahs-128	393	6	https://doi.org/10.1097/md.0000000000038164	https://doi.org/10.1097/md.0000000000038164	NUM
asodahs-128	393	7	https://doi.org/10.1007/978-3-031-69150-8_26	https://doi.org/10.1007/978-3-031-69150-8_26	PROPN
asodahs-128	393	8	https://doi.org/10.1007/978-3-031-69150-8_26	https://doi.org/10.1007/978-3-031-69150-8_26	ADP
asodahs-128	393	9	https://doi.org/10.1016/s0048-9697(01)01133-0	https://doi.org/10.1016/s0048-9697(01)01133-0	ADV
asodahs-128	393	10	https://doi.org/10.1016/j.tplants.2018.09.008	https://doi.org/10.1016/j.tplants.2018.09.008	NOUN
asodahs-128	393	11	https://doi.org/10.1097/00000441-199012000-00005	https://doi.org/10.1097/00000441-199012000-00005	VERB
asodahs-128	393	12	https://doi.org/10.1152/ajpendo.1998.274.2.e357	https://doi.org/10.1152/ajpendo.1998.274.2.e357	PROPN
asodahs-128	393	13	emmanuel	emmanuel	PROPN
asodahs-128	393	14	ifeanyi	ifeanyi	PROPN
asodahs-128	393	15	obeagu	obeagu	PROPN
asodahs-128	393	16	asian	asian	PROPN
asodahs-128	393	17	journal	journal	PROPN
asodahs-128	393	18	of	of	ADP
asodahs-128	393	19	dental	dental	ADJ
asodahs-128	393	20	and	and	CCONJ
asodahs-128	393	21	health	health	NOUN
asodahs-128	393	22	sciences	science	NOUN
asodahs-128	393	23	.	.	PUNCT
asodahs-128	394	1	2025	2025	NUM
asodahs-128	394	2	;	;	PUNCT
asodahs-128	394	3	5(3):1	5(3):1	NUM
asodahs-128	394	4	-	-	SYM
asodahs-128	394	5	5	5	NUM
asodahs-128	395	1	[	[	X
asodahs-128	395	2	5	5	NUM
asodahs-128	395	3	]	]	PUNCT
asodahs-128	395	4	ajdhs.com	ajdhs.com	X
asodahs-128	395	5	21	21	NUM
asodahs-128	395	6	.	.	PUNCT
asodahs-128	396	1	jackson	jackson	PROPN
asodahs-128	396	2	aa	aa	PROPN
asodahs-128	396	3	.	.	PUNCT
asodahs-128	397	1	the	the	DET
asodahs-128	397	2	use	use	NOUN
asodahs-128	397	3	of	of	ADP
asodahs-128	397	4	stable	stable	ADJ
asodahs-128	397	5	isotopes	isotope	NOUN
asodahs-128	397	6	to	to	PART
asodahs-128	397	7	study	study	VERB
asodahs-128	397	8	nitrogen	nitrogen	NOUN
asodahs-128	397	9	metabolism	metabolism	NOUN
asodahs-128	397	10	in	in	ADP
asodahs-128	397	11	homozygous	homozygous	ADJ
asodahs-128	397	12	sickle	sickle	NOUN
asodahs-128	397	13	cell	cell	NOUN
asodahs-128	397	14	disease	disease	NOUN
asodahs-128	397	15	.	.	PUNCT
asodahs-128	398	1	ingenetic	ingenetic	ADJ
asodahs-128	398	2	factors	factor	NOUN
asodahs-128	398	3	in	in	ADP
asodahs-128	398	4	nutrition	nutrition	NOUN
asodahs-128	398	5	.	.	PUNCT
asodahs-128	399	1	1984	1984	NUM
asodahs-128	399	2	:	:	PUNCT
asodahs-128	399	3	297	297	NUM
asodahs-128	399	4	-	-	SYM
asodahs-128	399	5	315	315	NUM
asodahs-128	399	6	.	.	PUNCT
asodahs-128	400	1	academic	academic	ADJ
asodahs-128	400	2	press	press	NOUN
asodahs-128	400	3	,	,	PUNCT
asodahs-128	400	4	new	new	PROPN
asodahs-128	400	5	york	york	PROPN
asodahs-128	400	6	.	.	PUNCT
asodahs-128	401	1	https://doi.org/10.1016/b978-0-12-715950-8.50024-x	https://doi.org/10.1016/b978-0-12-715950-8.50024-x	ADP
asodahs-128	401	2	pmcid	pmcid	NOUN
asodahs-128	401	3	:	:	PUNCT
asodahs-128	401	4	pmc7131065	pmc7131065	PROPN
asodahs-128	401	5	22	22	NUM
asodahs-128	401	6	.	.	PUNCT
asodahs-128	402	1	schnog	schnog	PROPN
asodahs-128	402	2	jj	jj	PROPN
asodahs-128	402	3	,	,	PUNCT
asodahs-128	402	4	jager	jager	PROPN
asodahs-128	402	5	eh	eh	INTJ
asodahs-128	402	6	,	,	PUNCT
asodahs-128	402	7	van	van	PROPN
asodahs-128	402	8	der	der	PROPN
asodahs-128	402	9	dijs	dijs	PROPN
asodahs-128	402	10	fp	fp	PROPN
asodahs-128	402	11	,	,	PUNCT
asodahs-128	402	12	duits	duits	PROPN
asodahs-128	402	13	aj	aj	PROPN
asodahs-128	402	14	,	,	PUNCT
asodahs-128	402	15	moshage	moshage	NOUN
asodahs-128	402	16	h	h	NOUN
asodahs-128	402	17	,	,	PUNCT
asodahs-128	402	18	muskiet	muskiet	PROPN
asodahs-128	402	19	fd	fd	PROPN
asodahs-128	402	20	,	,	PUNCT
asodahs-128	402	21	muskiet	muskiet	PROPN
asodahs-128	402	22	fa	fa	PROPN
asodahs-128	402	23	.	.	PROPN
asodahs-128	402	24	evidence	evidence	NOUN
asodahs-128	402	25	for	for	ADP
asodahs-128	402	26	a	a	DET
asodahs-128	402	27	metabolic	metabolic	NOUN
asodahs-128	402	28	shift	shift	NOUN
asodahs-128	402	29	of	of	ADP
asodahs-128	402	30	arginine	arginine	NOUN
asodahs-128	402	31	metabolism	metabolism	NOUN
asodahs-128	402	32	in	in	ADP
asodahs-128	402	33	sickle	sickle	NOUN
asodahs-128	402	34	cell	cell	NOUN
asodahs-128	402	35	disease	disease	NOUN
asodahs-128	402	36	.	.	PUNCT
asodahs-128	403	1	annals	annal	NOUN
asodahs-128	403	2	of	of	ADP
asodahs-128	403	3	hematology	hematology	NOUN
asodahs-128	403	4	.	.	PUNCT
asodahs-128	404	1	2004	2004	NUM
asodahs-128	404	2	;	;	PUNCT
asodahs-128	404	3	83:371	83:371	NUM
asodahs-128	404	4	-	-	SYM
asodahs-128	404	5	375	375	NUM
asodahs-128	404	6	.	.	PUNCT
asodahs-128	405	1	https://doi.org/10.1007/s00277-004-0856-9	https://doi.org/10.1007/s00277-004-0856-9	NOUN
asodahs-128	405	2	pmid:15054669	pmid:15054669	NOUN
asodahs-128	405	3	23	23	NUM
asodahs-128	405	4	.	.	PUNCT
asodahs-128	406	1	darghouth	darghouth	PROPN
asodahs-128	406	2	d	d	PROPN
asodahs-128	406	3	,	,	PUNCT
asodahs-128	406	4	koehl	koehl	PROPN
asodahs-128	406	5	b	b	NOUN
asodahs-128	406	6	,	,	PUNCT
asodahs-128	406	7	madalinski	madalinski	NOUN
asodahs-128	406	8	g	g	PROPN
asodahs-128	406	9	,	,	PUNCT
asodahs-128	406	10	heilier	heilier	PROPN
asodahs-128	406	11	jf	jf	PROPN
asodahs-128	406	12	,	,	PUNCT
asodahs-128	406	13	bovee	bovee	NOUN
asodahs-128	406	14	p	p	PROPN
asodahs-128	406	15	,	,	PUNCT
asodahs-128	406	16	xu	xu	PROPN
asodahs-128	406	17	y	y	PROPN
asodahs-128	406	18	,	,	PUNCT
asodahs-128	406	19	olivier	olivier	PROPN
asodahs-128	406	20	mf	mf	PROPN
asodahs-128	406	21	,	,	PUNCT
asodahs-128	406	22	bartolucci	bartolucci	NOUN
asodahs-128	406	23	p	p	NOUN
asodahs-128	406	24	,	,	PUNCT
asodahs-128	406	25	benkerrou	benkerrou	PROPN
asodahs-128	406	26	m	m	PROPN
asodahs-128	406	27	,	,	PUNCT
asodahs-128	406	28	pissard	pissard	PROPN
asodahs-128	406	29	s	s	PROPN
asodahs-128	406	30	,	,	PUNCT
asodahs-128	406	31	colin	colin	PROPN
asodahs-128	406	32	y.	y.	PROPN
asodahs-128	406	33	pathophysiology	pathophysiology	PROPN
asodahs-128	406	34	of	of	ADP
asodahs-128	406	35	sickle	sickle	NOUN
asodahs-128	406	36	cell	cell	NOUN
asodahs-128	406	37	disease	disease	NOUN
asodahs-128	406	38	is	be	AUX
asodahs-128	406	39	mirrored	mirror	VERB
asodahs-128	406	40	by	by	ADP
asodahs-128	406	41	the	the	DET
asodahs-128	406	42	red	red	ADJ
asodahs-128	406	43	blood	blood	NOUN
asodahs-128	406	44	cell	cell	NOUN
asodahs-128	406	45	metabolome	metabolome	NOUN
asodahs-128	406	46	.	.	PUNCT
asodahs-128	407	1	blood	blood	NOUN
asodahs-128	407	2	,	,	PUNCT
asodahs-128	407	3	the	the	DET
asodahs-128	407	4	journal	journal	NOUN
asodahs-128	407	5	of	of	ADP
asodahs-128	407	6	the	the	DET
asodahs-128	407	7	american	american	ADJ
asodahs-128	407	8	society	society	NOUN
asodahs-128	407	9	of	of	ADP
asodahs-128	407	10	hematology	hematology	NOUN
asodahs-128	407	11	.	.	PUNCT
asodahs-128	408	1	2011	2011	NUM
asodahs-128	408	2	;	;	PUNCT
asodahs-128	408	3	117(6):e57	117(6):e57	NUM
asodahs-128	408	4	-	-	SYM
asodahs-128	408	5	66	66	NUM
asodahs-128	408	6	.	.	PUNCT
asodahs-128	409	1	https://doi.org/10.1182/blood-2010-07-299636	https://doi.org/10.1182/blood-2010-07-299636	PRON
asodahs-128	409	2	pmid:21135259	pmid:21135259	PRON
asodahs-128	409	3	24	24	NUM
asodahs-128	409	4	.	.	PUNCT
asodahs-128	410	1	morris	morris	PROPN
asodahs-128	410	2	cr	cr	PROPN
asodahs-128	410	3	,	,	PUNCT
asodahs-128	410	4	kato	kato	PROPN
asodahs-128	410	5	gj	gj	PROPN
asodahs-128	410	6	,	,	PUNCT
asodahs-128	410	7	poljakovic	poljakovic	PROPN
asodahs-128	410	8	m	m	PROPN
asodahs-128	410	9	,	,	PUNCT
asodahs-128	410	10	wang	wang	PROPN
asodahs-128	410	11	x	x	PROPN
asodahs-128	410	12	,	,	PUNCT
asodahs-128	410	13	blackwelder	blackwelder	PROPN
asodahs-128	410	14	wc	wc	PROPN
asodahs-128	410	15	,	,	PUNCT
asodahs-128	410	16	sachdev	sachdev	PROPN
asodahs-128	410	17	v	v	PROPN
asodahs-128	410	18	,	,	PUNCT
asodahs-128	410	19	hazen	hazen	PROPN
asodahs-128	410	20	sl	sl	PROPN
asodahs-128	410	21	,	,	PUNCT
asodahs-128	410	22	vichinsky	vichinsky	ADJ
asodahs-128	410	23	ep	ep	PROPN
asodahs-128	410	24	,	,	PUNCT
asodahs-128	410	25	morris	morris	PROPN
asodahs-128	410	26	sm	sm	PROPN
asodahs-128	410	27	,	,	PUNCT
asodahs-128	410	28	gladwin	gladwin	PROPN
asodahs-128	410	29	mt	mt	PROPN
asodahs-128	410	30	.	.	PROPN
asodahs-128	410	31	dysregulated	dysregulate	VERB
asodahs-128	410	32	arginine	arginine	NOUN
asodahs-128	410	33	metabolism	metabolism	NOUN
asodahs-128	410	34	,	,	PUNCT
asodahs-128	410	35	hemolysis	hemolysis	NOUN
asodahs-128	410	36	-	-	PUNCT
asodahs-128	410	37	associated	associate	VERB
asodahs-128	410	38	pulmonary	pulmonary	ADJ
asodahs-128	410	39	hypertension	hypertension	NOUN
asodahs-128	410	40	,	,	PUNCT
asodahs-128	410	41	and	and	CCONJ
asodahs-128	410	42	mortality	mortality	NOUN
asodahs-128	410	43	in	in	ADP
asodahs-128	410	44	sickle	sickle	NOUN
asodahs-128	410	45	cell	cell	NOUN
asodahs-128	410	46	disease	disease	NOUN
asodahs-128	410	47	.	.	PUNCT
asodahs-128	411	1	jama	jama	PROPN
asodahs-128	411	2	.	.	PUNCT
asodahs-128	412	1	2005	2005	NUM
asodahs-128	412	2	;	;	PUNCT
asodahs-128	412	3	294(1):81	294(1):81	NUM
asodahs-128	412	4	-	-	SYM
asodahs-128	412	5	90	90	NUM
asodahs-128	412	6	.	.	PUNCT
asodahs-128	413	1	https://doi.org/10.1001/jama.294.1.81	https://doi.org/10.1001/jama.294.1.81	NOUN
asodahs-128	413	2	pmid:15998894	pmid:15998894	ADJ
asodahs-128	413	3	pmcid	pmcid	NOUN
asodahs-128	413	4	:	:	PUNCT
asodahs-128	413	5	pmc2065861	pmc2065861	NOUN
asodahs-128	413	6	25	25	NUM
asodahs-128	413	7	.	.	PUNCT
asodahs-128	414	1	zhou	zhou	PROPN
asodahs-128	414	2	y	y	PROPN
asodahs-128	414	3	,	,	PUNCT
asodahs-128	414	4	yu	yu	PROPN
asodahs-128	414	5	x	x	NOUN
asodahs-128	414	6	,	,	PUNCT
asodahs-128	414	7	nicely	nicely	ADV
asodahs-128	414	8	a	a	PRON
asodahs-128	414	9	,	,	PUNCT
asodahs-128	414	10	cunningham	cunningham	PROPN
asodahs-128	414	11	g	g	PROPN
asodahs-128	414	12	,	,	PUNCT
asodahs-128	414	13	challa	challa	PROPN
asodahs-128	414	14	c	c	PROPN
asodahs-128	414	15	,	,	PUNCT
asodahs-128	414	16	mckinley	mckinley	PROPN
asodahs-128	414	17	k	k	PROPN
asodahs-128	414	18	,	,	PUNCT
asodahs-128	414	19	nickel	nickel	NOUN
asodahs-128	414	20	r	r	NOUN
asodahs-128	414	21	,	,	PUNCT
asodahs-128	414	22	campbell	campbell	PROPN
asodahs-128	414	23	a	a	PROPN
asodahs-128	414	24	,	,	PUNCT
asodahs-128	414	25	darbari	darbari	PROPN
asodahs-128	414	26	d	d	NOUN
asodahs-128	414	27	,	,	PUNCT
asodahs-128	414	28	summar	summar	PROPN
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asodahs-128	414	30	,	,	PUNCT
asodahs-128	414	31	majumdar	majumdar	PROPN
asodahs-128	414	32	s.	s.	PROPN
asodahs-128	414	33	amino	amino	PROPN
asodahs-128	414	34	acid	acid	PROPN
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asodahs-128	414	36	during	during	ADP
asodahs-128	414	37	sickle	sickle	PROPN
asodahs-128	414	38	cell	cell	NOUN
asodahs-128	414	39	pain	pain	NOUN
asodahs-128	414	40	crisis	crisis	NOUN
asodahs-128	414	41	shows	show	VERB
asodahs-128	414	42	significant	significant	ADJ
asodahs-128	414	43	alterations	alteration	NOUN
asodahs-128	414	44	related	relate	VERB
asodahs-128	414	45	to	to	ADP
asodahs-128	414	46	nitric	nitric	ADJ
asodahs-128	414	47	oxide	oxide	NOUN
asodahs-128	414	48	and	and	CCONJ
asodahs-128	414	49	energy	energy	NOUN
asodahs-128	414	50	metabolism	metabolism	NOUN
asodahs-128	414	51	.	.	PUNCT
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asodahs-128	415	3	and	and	CCONJ
asodahs-128	415	4	metabolism	metabolism	NOUN
asodahs-128	415	5	.	.	PUNCT
asodahs-128	416	1	2022	2022	NUM
asodahs-128	416	2	;	;	PUNCT
asodahs-128	416	3	137(1	137(1	NUM
asodahs-128	416	4	-	-	PUNCT
asodahs-128	416	5	2):146	2):146	PROPN
asodahs-128	416	6	-	-	PUNCT
asodahs-128	416	7	152	152	NUM
asodahs-128	416	8	.	.	PUNCT
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asodahs-128	417	2	pmid:36030599	pmid:36030599	VERB
asodahs-128	417	3	26	26	NUM
asodahs-128	417	4	.	.	PUNCT
asodahs-128	418	1	d'alessandro	d'alessandro	PROPN
asodahs-128	418	2	a	a	PRON
asodahs-128	418	3	,	,	PUNCT
asodahs-128	418	4	nouraie	nouraie	PROPN
asodahs-128	418	5	sm	sm	PROPN
asodahs-128	418	6	,	,	PUNCT
asodahs-128	418	7	zhang	zhang	PROPN
asodahs-128	418	8	y	y	PROPN
asodahs-128	418	9	,	,	PUNCT
asodahs-128	418	10	cendali	cendali	PROPN
asodahs-128	418	11	f	f	PROPN
asodahs-128	418	12	,	,	PUNCT
asodahs-128	418	13	gamboni	gamboni	PROPN
asodahs-128	418	14	f	f	NOUN
asodahs-128	418	15	,	,	PUNCT
asodahs-128	418	16	reisz	reisz	ADJ
asodahs-128	418	17	ja	ja	PROPN
asodahs-128	418	18	,	,	PUNCT
asodahs-128	418	19	zhang	zhang	PROPN
asodahs-128	419	1	x	x	PROPN
asodahs-128	419	2	,	,	PUNCT
asodahs-128	419	3	bartsch	bartsch	X
asodahs-128	419	4	kw	kw	PROPN
asodahs-128	419	5	,	,	PUNCT
asodahs-128	419	6	galbraith	galbraith	PROPN
asodahs-128	419	7	md	md	PROPN
asodahs-128	419	8	,	,	PUNCT
asodahs-128	419	9	espinosa	espinosa	PROPN
asodahs-128	419	10	jm	jm	PROPN
asodahs-128	419	11	,	,	PUNCT
asodahs-128	419	12	gordeuk	gordeuk	PROPN
asodahs-128	419	13	vr	vr	PROPN
asodahs-128	419	14	.	.	PROPN
asodahs-128	419	15	metabolic	metabolic	NOUN
asodahs-128	419	16	signatures	signature	NOUN
asodahs-128	419	17	of	of	ADP
asodahs-128	419	18	cardiorenal	cardiorenal	ADJ
asodahs-128	419	19	dysfunction	dysfunction	NOUN
asodahs-128	419	20	in	in	ADP
asodahs-128	419	21	plasma	plasma	NOUN
asodahs-128	419	22	from	from	ADP
asodahs-128	419	23	sickle	sickle	NOUN
asodahs-128	419	24	cell	cell	NOUN
asodahs-128	419	25	patients	patient	NOUN
asodahs-128	419	26	as	as	ADP
asodahs-128	419	27	a	a	DET
asodahs-128	419	28	function	function	NOUN
asodahs-128	419	29	of	of	ADP
asodahs-128	419	30	therapeutic	therapeutic	ADJ
asodahs-128	419	31	transfusion	transfusion	NOUN
asodahs-128	419	32	and	and	CCONJ
asodahs-128	419	33	hydroxyurea	hydroxyurea	ADJ
asodahs-128	419	34	treatment	treatment	NOUN
asodahs-128	419	35	.	.	PUNCT
asodahs-128	420	1	haematologica	haematologica	PROPN
asodahs-128	420	2	.	.	PUNCT
asodahs-128	421	1	2023	2023	NUM
asodahs-128	421	2	;	;	PUNCT
asodahs-128	422	1	108(12):3418	108(12):3418	PROPN
asodahs-128	422	2	.	.	PUNCT
asodahs-128	423	1	https://doi.org/10.3324/haematol.2023.283288	https://doi.org/10.3324/haematol.2023.283288	PROPN
asodahs-128	423	2	pmid:37439373	pmid:37439373	VERB
asodahs-128	423	3	pmcid	pmcid	NOUN
asodahs-128	423	4	:	:	PUNCT
asodahs-128	423	5	pmc10690926	pmc10690926	NOUN
asodahs-128	423	6	27	27	NUM
asodahs-128	423	7	.	.	PUNCT
asodahs-128	424	1	obeagu	obeagu	PROPN
asodahs-128	424	2	ei	ei	PROPN
asodahs-128	424	3	,	,	PUNCT
asodahs-128	424	4	prajapati	prajapati	PROPN
asodahs-128	424	5	sk	sk	PROPN
asodahs-128	424	6	,	,	PUNCT
asodahs-128	424	7	maurya	maurya	PROPN
asodahs-128	424	8	sd	sd	PROPN
asodahs-128	424	9	,	,	PUNCT
asodahs-128	424	10	maternal	maternal	ADJ
asodahs-128	424	11	anemia	anemia	NOUN
asodahs-128	424	12	in	in	ADP
asodahs-128	424	13	the	the	DET
asodahs-128	424	14	context	context	NOUN
asodahs-128	424	15	of	of	ADP
asodahs-128	424	16	infectious	infectious	ADJ
asodahs-128	424	17	diseases	disease	NOUN
asodahs-128	424	18	during	during	ADP
asodahs-128	424	19	pregnancy	pregnancy	NOUN
asodahs-128	424	20	:	:	PUNCT
asodahs-128	424	21	a	a	DET
asodahs-128	424	22	review	review	NOUN
asodahs-128	424	23	,	,	PUNCT
asodahs-128	424	24	international	international	ADJ
asodahs-128	424	25	journal	journal	NOUN
asodahs-128	424	26	of	of	ADP
asodahs-128	424	27	medical	medical	ADJ
asodahs-128	424	28	sciences	sciences	PROPN
asodahs-128	424	29	and	and	CCONJ
asodahs-128	424	30	pharma	pharma	PROPN
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asodahs-128	424	34	-	-	SYM
asodahs-128	424	35	13	13	NUM
asodahs-128	424	36	https://doi.org/10.22270/ijmspr.v11i1.134	https://doi.org/10.22270/ijmspr.v11i1.134	PROPN
asodahs-128	424	37	28	28	NUM
asodahs-128	424	38	.	.	PUNCT
asodahs-128	425	1	obeagu	obeagu	PROPN
asodahs-128	425	2	ei	ei	PROPN
asodahs-128	425	3	,	,	PUNCT
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asodahs-128	425	5	ph	ph	VERB
asodahs-128	425	6	.	.	PROPN
asodahs-128	425	7	inclusive	inclusive	ADJ
asodahs-128	425	8	healthcare	healthcare	PROPN
asodahs-128	425	9	approaches	approach	NOUN
asodahs-128	425	10	for	for	ADP
asodahs-128	425	11	hivpositive	hivpositive	ADJ
asodahs-128	425	12	sickle	sickle	NOUN
asodahs-128	425	13	cell	cell	NOUN
asodahs-128	425	14	disease	disease	NOUN
asodahs-128	425	15	patients	patient	NOUN
asodahs-128	425	16	:	:	PUNCT
asodahs-128	425	17	a	a	DET
asodahs-128	425	18	review	review	NOUN
asodahs-128	425	19	.	.	PUNCT
asodahs-128	426	1	current	current	ADJ
asodahs-128	426	2	research	research	NOUN
asodahs-128	426	3	in	in	ADP
asodahs-128	426	4	biological	biological	ADJ
asodahs-128	426	5	sciences	science	NOUN
asodahs-128	426	6	.	.	PUNCT
asodahs-128	427	1	2025;1(1):01	2025;1(1):01	NUM
asodahs-128	427	2	-	-	SYM
asodahs-128	427	3	8	8	NUM
asodahs-128	427	4	.	.	NOUN
asodahs-128	427	5	29	29	NUM
asodahs-128	427	6	.	.	PUNCT
asodahs-128	428	1	obeagu	obeagu	PROPN
asodahs-128	428	2	ei	ei	PROPN
asodahs-128	428	3	,	,	PUNCT
asodahs-128	428	4	obeagu	obeagu	PROPN
asodahs-128	428	5	gu	gu	PROPN
asodahs-128	428	6	.	.	PUNCT
asodahs-128	428	7	managing	manage	VERB
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asodahs-128	428	9	challenges	challenge	NOUN
asodahs-128	428	10	:	:	PUNCT
asodahs-128	428	11	diarrhea	diarrhea	NOUN
asodahs-128	428	12	in	in	ADP
asodahs-128	428	13	sickle	sickle	NOUN
asodahs-128	428	14	cell	cell	NOUN
asodahs-128	428	15	anemia	anemia	NOUN
asodahs-128	428	16	.	.	PUNCT
asodahs-128	429	1	medicine	medicine	NOUN
asodahs-128	429	2	.	.	PUNCT
asodahs-128	430	1	2024	2024	NUM
asodahs-128	430	2	;	;	PUNCT
asodahs-128	430	3	103(18):e38075	103(18):e38075	NUM
asodahs-128	430	4	.	.	PUNCT
asodahs-128	431	1	https://doi.org/10.1097/md.0000000000038075	https://doi.org/10.1097/md.0000000000038075	X
asodahs-128	431	2	pmid:38701274	pmid:38701274	ADJ
asodahs-128	431	3	pmcid	pmcid	NOUN
asodahs-128	431	4	:	:	PUNCT
asodahs-128	431	5	pmc11062666	pmc11062666	NOUN
asodahs-128	431	6	30	30	NUM
asodahs-128	431	7	.	.	PUNCT
asodahs-128	432	1	obeagu	obeagu	PROPN
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asodahs-128	432	3	,	,	PUNCT
asodahs-128	432	4	obeagu	obeagu	PROPN
asodahs-128	432	5	gu	gu	PROPN
asodahs-128	432	6	.	.	PUNCT
asodahs-128	432	7	living	live	VERB
asodahs-128	432	8	with	with	ADP
asodahs-128	432	9	sickle	sickle	NOUN
asodahs-128	432	10	cell	cell	NOUN
asodahs-128	432	11	in	in	ADP
asodahs-128	432	12	uganda	uganda	PROPN
asodahs-128	432	13	:	:	PUNCT
asodahs-128	432	14	a	a	DET
asodahs-128	432	15	comprehensive	comprehensive	ADJ
asodahs-128	432	16	perspective	perspective	NOUN
asodahs-128	432	17	on	on	ADP
asodahs-128	432	18	challenges	challenge	NOUN
asodahs-128	432	19	,	,	PUNCT
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asodahs-128	432	22	,	,	PUNCT
asodahs-128	432	23	and	and	CCONJ
asodahs-128	432	24	health	health	NOUN
asodahs-128	432	25	interventions	intervention	NOUN
asodahs-128	432	26	.	.	PUNCT
asodahs-128	433	1	medicine	medicine	NOUN
asodahs-128	433	2	.	.	PUNCT
asodahs-128	434	1	2024	2024	NUM
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asodahs-128	434	4	.	.	PUNCT
asodahs-128	435	1	https://doi.org/10.1097/md.0000000000041062	https://doi.org/10.1097/md.0000000000041062	PRON
asodahs-128	435	2	pmid:39705436	pmid:39705436	NOUN
asodahs-128	435	3	pmcid	pmcid	NOUN
asodahs-128	435	4	:	:	PUNCT
asodahs-128	435	5	pmc11666137	pmc11666137	NOUN
asodahs-128	435	6	31	31	NUM
asodahs-128	435	7	.	.	PUNCT
asodahs-128	436	1	obeagu	obeagu	PROPN
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asodahs-128	436	3	,	,	PUNCT
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asodahs-128	436	6	,	,	PUNCT
asodahs-128	436	7	obeagu	obeagu	ADJ
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asodahs-128	436	9	.	.	PUNCT
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asodahs-128	436	18	in	in	ADP
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asodahs-128	436	23	.	.	PUNCT
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asodahs-128	437	6	.	.	PUNCT
asodahs-128	438	1	2024	2024	NUM
asodahs-128	438	2	;	;	PUNCT
asodahs-128	438	3	86(10):6021	86(10):6021	NUM
asodahs-128	438	4	-	-	SYM
asodahs-128	438	5	6036	6036	NUM
asodahs-128	438	6	.	.	PUNCT
asodahs-128	439	1	https://doi.org/10.1097/ms9.0000000000002534	https://doi.org/10.1097/ms9.0000000000002534	PROPN
asodahs-128	439	2	pmid:39359845	pmid:39359845	ADJ
asodahs-128	439	3	pmcid	pmcid	NOUN
asodahs-128	439	4	:	:	PUNCT
asodahs-128	439	5	pmc11444627	pmc11444627	NOUN
asodahs-128	439	6	32	32	NUM
asodahs-128	439	7	.	.	PUNCT
asodahs-128	440	1	bell	bell	PROPN
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asodahs-128	440	3	,	,	PUNCT
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asodahs-128	440	5	t	t	PROPN
asodahs-128	440	6	,	,	PUNCT
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asodahs-128	440	13	cell	cell	PROPN
asodahs-128	440	14	disease	disease	NOUN
asodahs-128	440	15	update	update	NOUN
asodahs-128	440	16	:	:	PUNCT
asodahs-128	440	17	new	new	ADJ
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asodahs-128	440	19	and	and	CCONJ
asodahs-128	440	20	challenging	challenge	VERB
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asodahs-128	440	22	interventions	intervention	NOUN
asodahs-128	440	23	.	.	PUNCT
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asodahs-128	441	2	.	.	PUNCT
asodahs-128	442	1	2024	2024	NUM
asodahs-128	442	2	;	;	PUNCT
asodahs-128	442	3	16(2):258	16(2):258	NUM
asodahs-128	442	4	.	.	PUNCT
asodahs-128	443	1	https://doi.org/10.3390/nu16020258	https://doi.org/10.3390/nu16020258	PROPN
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asodahs-128	443	3	pmcid	pmcid	NOUN
asodahs-128	443	4	:	:	PUNCT
asodahs-128	443	5	pmc10820494	pmc10820494	VERB
asodahs-128	443	6	33	33	NUM
asodahs-128	443	7	.	.	PUNCT
asodahs-128	444	1	khan	khan	PROPN
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asodahs-128	444	6	,	,	PUNCT
asodahs-128	444	7	ali	ali	PROPN
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asodahs-128	444	9	,	,	PUNCT
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asodahs-128	444	14	a	a	PRON
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asodahs-128	444	31	precipitating	precipitating	NOUN
asodahs-128	444	32	factors	factor	NOUN
asodahs-128	444	33	and	and	CCONJ
asodahs-128	444	34	targeted	target	VERB
asodahs-128	444	35	therapies	therapy	NOUN
asodahs-128	444	36	in	in	ADP
asodahs-128	444	37	combating	combat	VERB
asodahs-128	444	38	the	the	DET
asodahs-128	444	39	perils	peril	NOUN
asodahs-128	444	40	of	of	ADP
asodahs-128	444	41	sickle	sickle	NOUN
asodahs-128	444	42	cell	cell	NOUN
asodahs-128	444	43	disease	disease	NOUN
asodahs-128	444	44	---	---	PUNCT
asodahs-128	444	45	a	a	DET
asodahs-128	444	46	special	special	ADJ
asodahs-128	444	47	nutritional	nutritional	ADJ
asodahs-128	444	48	consideration	consideration	NOUN
asodahs-128	444	49	.	.	PUNCT
asodahs-128	445	1	nutrition	nutrition	NOUN
asodahs-128	445	2	&	&	CCONJ
asodahs-128	445	3	metabolism	metabolism	NOUN
asodahs-128	445	4	.	.	PUNCT
asodahs-128	446	1	2016	2016	NUM
asodahs-128	446	2	;	;	PUNCT
asodahs-128	447	1	13:1	13:1	NUM
asodahs-128	447	2	-	-	SYM
asodahs-128	447	3	2	2	NUM
asodahs-128	447	4	.	.	PUNCT
asodahs-128	447	5	https://doi.org/10.1186/s12986-016-0109-7	https://doi.org/10.1186/s12986-016-0109-7	NOUN
asodahs-128	447	6	pmid:27508000	pmid:27508000	PRON
asodahs-128	447	7	pmcid	pmcid	NOUN
asodahs-128	447	8	:	:	PUNCT
asodahs-128	447	9	pmc4977632	pmc4977632	NOUN
asodahs-128	447	10	34	34	NUM
asodahs-128	447	11	.	.	PUNCT
asodahs-128	448	1	patel	patel	PROPN
asodahs-128	448	2	s	s	PART
asodahs-128	448	3	,	,	PUNCT
asodahs-128	448	4	patel	patel	PROPN
asodahs-128	448	5	r	r	PROPN
asodahs-128	448	6	,	,	PUNCT
asodahs-128	448	7	mukkala	mukkala	PROPN
asodahs-128	448	8	sr	sr	PROPN
asodahs-128	448	9	,	,	PUNCT
asodahs-128	448	10	akabari	akabari	ADP
asodahs-128	448	11	a.	a.	NOUN
asodahs-128	448	12	emerging	emerge	VERB
asodahs-128	448	13	therapies	therapy	NOUN
asodahs-128	448	14	and	and	CCONJ
asodahs-128	448	15	management	management	NOUN
asodahs-128	448	16	approaches	approach	NOUN
asodahs-128	448	17	in	in	ADP
asodahs-128	448	18	sickle	sickle	NOUN
asodahs-128	448	19	cell	cell	NOUN
asodahs-128	448	20	disease	disease	NOUN
asodahs-128	448	21	(	(	PUNCT
asodahs-128	448	22	scd	scd	NOUN
asodahs-128	448	23	):	):	PUNCT
asodahs-128	448	24	a	a	DET
asodahs-128	448	25	critical	critical	ADJ
asodahs-128	448	26	review	review	NOUN
asodahs-128	448	27	.	.	PUNCT
asodahs-128	449	1	journal	journal	NOUN
asodahs-128	449	2	of	of	ADP
asodahs-128	449	3	phytonanotechnology	phytonanotechnology	PROPN
asodahs-128	449	4	and	and	CCONJ
asodahs-128	449	5	pharmaceutical	pharmaceutical	NOUN
asodahs-128	449	6	sciences	science	NOUN
asodahs-128	449	7	.	.	PUNCT
asodahs-128	450	1	2023	2023	NUM
asodahs-128	450	2	;	;	PUNCT
asodahs-128	450	3	3(3):1	3(3):1	NUM
asodahs-128	450	4	-	-	SYM
asodahs-128	450	5	1	1	NUM
asodahs-128	450	6	.	.	PUNCT
asodahs-128	451	1	https://doi.org/10.54085/jpps.2023.3.3.3	https://doi.org/10.54085/jpps.2023.3.3.3	NOUN
asodahs-128	451	2	35	35	NUM
asodahs-128	451	3	.	.	PUNCT
asodahs-128	452	1	obeagu	obeagu	PROPN
asodahs-128	452	2	ei	ei	PROPN
asodahs-128	452	3	,	,	PUNCT
asodahs-128	452	4	prajapati	prajapati	PROPN
asodahs-128	452	5	sk	sk	PROPN
asodahs-128	452	6	,	,	PUNCT
asodahs-128	452	7	maurya	maurya	PROPN
asodahs-128	452	8	sd	sd	PROPN
asodahs-128	452	9	,	,	PUNCT
asodahs-128	452	10	anemia	anemia	NOUN
asodahs-128	452	11	in	in	ADP
asodahs-128	452	12	pregnancy	pregnancy	NOUN
asodahs-128	452	13	:	:	PUNCT
asodahs-128	452	14	exploring	explore	VERB
asodahs-128	452	15	non	non	ADJ
asodahs-128	452	16	-	-	ADJ
asodahs-128	452	17	iron	iron	ADJ
asodahs-128	452	18	deficiency	deficiency	NOUN
asodahs-128	452	19	causes	cause	NOUN
asodahs-128	452	20	,	,	PUNCT
asodahs-128	452	21	international	international	ADJ
asodahs-128	452	22	journal	journal	NOUN
asodahs-128	452	23	of	of	ADP
asodahs-128	452	24	medical	medical	ADJ
asodahs-128	452	25	sciences	sciences	PROPN
asodahs-128	452	26	and	and	CCONJ
asodahs-128	452	27	pharma	pharma	PROPN
asodahs-128	452	28	research	research	NOUN
asodahs-128	452	29	,	,	PUNCT
asodahs-128	452	30	2025;11(1):1	2025;11(1):1	NUM
asodahs-128	452	31	-	-	SYM
asodahs-128	452	32	7	7	NUM
asodahs-128	452	33	https://doi.org/10.22270/ijmspr.v11i1.130	https://doi.org/10.22270/ijmspr.v11i1.130	ADP
asodahs-128	452	34	36	36	NUM
asodahs-128	452	35	.	.	PUNCT
asodahs-128	453	1	boma	boma	PROPN
asodahs-128	453	2	pm	pm	PROPN
asodahs-128	453	3	,	,	PUNCT
asodahs-128	453	4	kaponda	kaponda	CCONJ
asodahs-128	453	5	aa	aa	PROPN
asodahs-128	453	6	,	,	PUNCT
asodahs-128	453	7	panda	panda	NOUN
asodahs-128	453	8	j	j	PROPN
asodahs-128	453	9	,	,	PUNCT
asodahs-128	453	10	bonnechère	bonnechère	PROPN
asodahs-128	453	11	b.	b.	PROPN
asodahs-128	453	12	enhancing	enhance	VERB
asodahs-128	453	13	the	the	DET
asodahs-128	453	14	management	management	NOUN
asodahs-128	453	15	of	of	ADP
asodahs-128	453	16	pediatric	pediatric	ADJ
asodahs-128	453	17	sickle	sickle	NOUN
asodahs-128	453	18	cell	cell	NOUN
asodahs-128	453	19	disease	disease	NOUN
asodahs-128	453	20	by	by	ADP
asodahs-128	453	21	integrating	integrate	VERB
asodahs-128	453	22	functional	functional	ADJ
asodahs-128	453	23	evaluation	evaluation	NOUN
asodahs-128	453	24	to	to	PART
asodahs-128	453	25	mitigate	mitigate	VERB
asodahs-128	453	26	the	the	DET
asodahs-128	453	27	burden	burden	NOUN
asodahs-128	453	28	of	of	ADP
asodahs-128	453	29	vaso	vaso	NOUN
asodahs-128	453	30	-	-	PUNCT
asodahs-128	453	31	occlusive	occlusive	ADJ
asodahs-128	453	32	crises	crisis	NOUN
asodahs-128	453	33	.	.	PUNCT
asodahs-128	454	1	journal	journal	NOUN
asodahs-128	454	2	of	of	ADP
asodahs-128	454	3	vascular	vascular	ADJ
asodahs-128	454	4	diseases	disease	NOUN
asodahs-128	454	5	.	.	PUNCT
asodahs-128	455	1	2024	2024	NUM
asodahs-128	455	2	;	;	PUNCT
asodahs-128	455	3	3(1):77	3(1):77	NUM
asodahs-128	455	4	-	-	SYM
asodahs-128	455	5	87	87	NUM
asodahs-128	455	6	.	.	PUNCT
asodahs-128	456	1	https://doi.org/10.3390/jvd3010007	https://doi.org/10.3390/jvd3010007	PROPN
asodahs-128	456	2	37	37	NUM
asodahs-128	456	3	.	.	PUNCT
asodahs-128	457	1	obeagu	obeagu	PROPN
asodahs-128	457	2	ei	ei	PROPN
asodahs-128	457	3	,	,	PUNCT
asodahs-128	457	4	chukwu	chukwu	NOUN
asodahs-128	457	5	ph	ph	VERB
asodahs-128	457	6	.	.	PROPN
asodahs-128	457	7	inclusive	inclusive	ADJ
asodahs-128	457	8	healthcare	healthcare	PROPN
asodahs-128	457	9	approaches	approach	NOUN
asodahs-128	457	10	for	for	ADP
asodahs-128	457	11	hivpositive	hivpositive	ADJ
asodahs-128	457	12	sickle	sickle	NOUN
asodahs-128	457	13	cell	cell	NOUN
asodahs-128	457	14	disease	disease	NOUN
asodahs-128	457	15	patients	patient	NOUN
asodahs-128	457	16	:	:	PUNCT
asodahs-128	457	17	a	a	DET
asodahs-128	457	18	review	review	NOUN
asodahs-128	457	19	.	.	PUNCT
asodahs-128	458	1	current	current	ADJ
asodahs-128	458	2	research	research	NOUN
asodahs-128	458	3	in	in	ADP
asodahs-128	458	4	biological	biological	ADJ
asodahs-128	458	5	sciences	science	NOUN
asodahs-128	458	6	.	.	PUNCT
asodahs-128	459	1	2025;1(1):01	2025;1(1):01	NUM
asodahs-128	459	2	-	-	SYM
asodahs-128	459	3	8	8	NUM
asodahs-128	459	4	.	.	PUNCT
asodahs-128	460	1	https://doi.org/10.1016/b978-0-12-715950-8.50024-x	https://doi.org/10.1016/b978-0-12-715950-8.50024-x	INTJ
asodahs-128	460	2	https://doi.org/10.1007/s00277-004-0856-9	https://doi.org/10.1007/s00277-004-0856-9	NOUN
asodahs-128	460	3	https://doi.org/10.1182/blood-2010-07-299636	https://doi.org/10.1182/blood-2010-07-299636	NUM
asodahs-128	461	1	https://doi.org/10.1001/jama.294.1.81	https://doi.org/10.1001/jama.294.1.81	NOUN
asodahs-128	461	2	https://doi.org/10.1016/j.ymgme.2022.08.004	https://doi.org/10.1016/j.ymgme.2022.08.004	X
asodahs-128	461	3	https://doi.org/10.3324/haematol.2023.283288	https://doi.org/10.3324/haematol.2023.283288	PROPN
asodahs-128	461	4	https://doi.org/10.22270/ijmspr.v11i1.134	https://doi.org/10.22270/ijmspr.v11i1.134	PROPN
asodahs-128	461	5	https://doi.org/10.1097/md.0000000000038075	https://doi.org/10.1097/md.0000000000038075	PRON
asodahs-128	461	6	https://doi.org/10.1097/md.0000000000041062	https://doi.org/10.1097/md.0000000000041062	PRON
asodahs-128	461	7	https://doi.org/10.1097/ms9.0000000000002534	https://doi.org/10.1097/ms9.0000000000002534	VERB
asodahs-128	461	8	https://doi.org/10.3390/nu16020258	https://doi.org/10.3390/nu16020258	ADP
asodahs-128	461	9	https://doi.org/10.1186/s12986-016-0109-7	https://doi.org/10.1186/s12986-016-0109-7	PROPN
asodahs-128	461	10	https://doi.org/10.54085/jpps.2023.3.3.3	https://doi.org/10.54085/jpps.2023.3.3.3	NOUN
asodahs-128	461	11	https://doi.org/10.22270/ijmspr.v11i1.130	https://doi.org/10.22270/ijmspr.v11i1.130	ADP
asodahs-128	461	12	https://doi.org/10.3390/jvd3010007	https://doi.org/10.3390/jvd3010007	ADJ