id	sid	tid	token	lemma	pos
asodahs-134	1	1	emmanuel	emmanuel	PROPN
asodahs-134	1	2	ifeanyi	ifeanyi	PROPN
asodahs-134	1	3	obeagu	obeagu	PROPN
asodahs-134	1	4	asian	asian	PROPN
asodahs-134	1	5	journal	journal	PROPN
asodahs-134	1	6	of	of	ADP
asodahs-134	1	7	dental	dental	ADJ
asodahs-134	1	8	and	and	CCONJ
asodahs-134	1	9	health	health	NOUN
asodahs-134	1	10	sciences	science	NOUN
asodahs-134	1	11	.	.	PUNCT
asodahs-134	1	12	2025	2025	NUM
asodahs-134	1	13	;	;	PUNCT
asodahs-134	1	14	5(3):6	5(3):6	NUM
asodahs-134	1	15	-	-	SYM
asodahs-134	1	16	12	12	NUM
asodahs-134	1	17	[	[	X
asodahs-134	1	18	6	6	NUM
asodahs-134	1	19	]	]	PUNCT
asodahs-134	1	20	ajdhs.com	ajdhs.com	X
asodahs-134	1	21	available	available	ADJ
asodahs-134	1	22	online	online	ADV
asodahs-134	1	23	at	at	ADP
asodahs-134	1	24	ajdhs.com	ajdhs.com	X
asodahs-134	1	25	asian	asian	ADJ
asodahs-134	1	26	journal	journal	NOUN
asodahs-134	1	27	of	of	ADP
asodahs-134	1	28	dental	dental	ADJ
asodahs-134	1	29	and	and	CCONJ
asodahs-134	1	30	health	health	NOUN
asodahs-134	1	31	sciences	science	NOUN
asodahs-134	1	32	open	open	VERB
asodahs-134	1	33	access	access	NOUN
asodahs-134	1	34	to	to	ADP
asodahs-134	1	35	dental	dental	ADJ
asodahs-134	1	36	and	and	CCONJ
asodahs-134	1	37	medical	medical	ADJ
asodahs-134	1	38	research	research	NOUN
asodahs-134	1	39	copyright	copyright	NOUN
asodahs-134	1	40	©	©	ADP
asodahs-134	1	41	2025	2025	NUM
asodahs-134	1	42	the	the	DET
asodahs-134	1	43	author(s	author(s	NOUN
asodahs-134	1	44	):	):	PUNCT
asodahs-134	1	45	this	this	PRON
asodahs-134	1	46	is	be	AUX
asodahs-134	1	47	an	an	DET
asodahs-134	1	48	open	open	ADJ
asodahs-134	1	49	-	-	PUNCT
asodahs-134	1	50	access	access	NOUN
asodahs-134	1	51	article	article	NOUN
asodahs-134	1	52	distributed	distribute	VERB
asodahs-134	1	53	under	under	ADP
asodahs-134	1	54	the	the	DET
asodahs-134	1	55	terms	term	NOUN
asodahs-134	1	56	of	of	ADP
asodahs-134	1	57	the	the	DET
asodahs-134	1	58	cc	cc	PROPN
asodahs-134	1	59	by	by	ADP
asodahs-134	1	60	-	-	PUNCT
asodahs-134	1	61	nc	nc	PROPN
asodahs-134	1	62	4.0	4.0	NUM
asodahs-134	1	63	which	which	PRON
asodahs-134	1	64	permits	permit	VERB
asodahs-134	1	65	unrestricted	unrestricted	ADJ
asodahs-134	1	66	use	use	NOUN
asodahs-134	1	67	,	,	PUNCT
asodahs-134	1	68	distribution	distribution	NOUN
asodahs-134	1	69	,	,	PUNCT
asodahs-134	1	70	and	and	CCONJ
asodahs-134	1	71	reproduction	reproduction	NOUN
asodahs-134	1	72	in	in	ADP
asodahs-134	1	73	any	any	DET
asodahs-134	1	74	medium	medium	NOUN
asodahs-134	1	75	for	for	ADP
asodahs-134	1	76	non	non	ADJ
asodahs-134	1	77	-	-	ADJ
asodahs-134	1	78	commercial	commercial	ADJ
asodahs-134	1	79	use	use	NOUN
asodahs-134	1	80	provided	provide	VERB
asodahs-134	1	81	the	the	DET
asodahs-134	1	82	original	original	ADJ
asodahs-134	1	83	author	author	NOUN
asodahs-134	1	84	and	and	CCONJ
asodahs-134	1	85	source	source	NOUN
asodahs-134	1	86	are	be	AUX
asodahs-134	1	87	credited	credit	VERB
asodahs-134	1	88	nitric	nitric	ADJ
asodahs-134	1	89	oxide	oxide	NOUN
asodahs-134	1	90	bioavailability	bioavailability	NOUN
asodahs-134	1	91	and	and	CCONJ
asodahs-134	1	92	vascular	vascular	ADJ
asodahs-134	1	93	dysfunction	dysfunction	NOUN
asodahs-134	1	94	in	in	ADP
asodahs-134	1	95	sickle	sickle	NOUN
asodahs-134	1	96	cell	cell	NOUN
asodahs-134	1	97	patients	patient	NOUN
asodahs-134	1	98	:	:	PUNCT
asodahs-134	1	99	a	a	DET
asodahs-134	1	100	pathophysiological	pathophysiological	ADJ
asodahs-134	1	101	nexus	nexus	NOUN
asodahs-134	1	102	*	*	PUNCT
asodahs-134	1	103	emmanuel	emmanuel	PROPN
asodahs-134	1	104	ifeanyi	ifeanyi	PROPN
asodahs-134	1	105	obeagu	obeagu	PROPN
asodahs-134	1	106	department	department	PROPN
asodahs-134	1	107	of	of	ADP
asodahs-134	1	108	biomedical	biomedical	ADJ
asodahs-134	1	109	and	and	CCONJ
asodahs-134	1	110	laboratory	laboratory	NOUN
asodahs-134	1	111	science	science	PROPN
asodahs-134	1	112	,	,	PUNCT
asodahs-134	1	113	africa	africa	PROPN
asodahs-134	1	114	university	university	PROPN
asodahs-134	1	115	,	,	PUNCT
asodahs-134	1	116	zimbabwe	zimbabwe	PROPN
asodahs-134	1	117	.	.	PUNCT
asodahs-134	2	1	article	article	NOUN
asodahs-134	2	2	info	info	NOUN
asodahs-134	2	3	:	:	PUNCT
asodahs-134	3	1	_	_	PUNCT
asodahs-134	4	1	_	_	PUNCT
asodahs-134	5	1	_	_	PUNCT
asodahs-134	6	1	_	_	PUNCT
asodahs-134	7	1	_	_	PUNCT
asodahs-134	8	1	_	_	PUNCT
asodahs-134	9	1	_	_	PUNCT
asodahs-134	10	1	_	_	PUNCT
asodahs-134	11	1	_	_	PUNCT
asodahs-134	12	1	_	_	PUNCT
asodahs-134	13	1	_	_	PUNCT
asodahs-134	14	1	_	_	PUNCT
asodahs-134	15	1	_	_	PUNCT
asodahs-134	16	1	_	_	PUNCT
asodahs-134	17	1	_	_	PUNCT
asodahs-134	18	1	_	_	PUNCT
asodahs-134	19	1	_	_	PUNCT
asodahs-134	20	1	_	_	PUNCT
asodahs-134	21	1	_	_	PUNCT
asodahs-134	22	1	_	_	PUNCT
asodahs-134	23	1	_	_	PUNCT
asodahs-134	24	1	_	_	PUNCT
asodahs-134	25	1	_	_	PUNCT
asodahs-134	26	1	_	_	PUNCT
asodahs-134	27	1	_	_	PUNCT
asodahs-134	28	1	_	_	PUNCT
asodahs-134	29	1	_	_	PUNCT
asodahs-134	30	1	_	_	PUNCT
asodahs-134	31	1	_	_	PUNCT
asodahs-134	32	1	_	_	PUNCT
asodahs-134	33	1	_	_	PUNCT
asodahs-134	34	1	_	_	PUNCT
asodahs-134	35	1	_	_	PUNCT
asodahs-134	36	1	_	_	PUNCT
asodahs-134	37	1	_	_	PUNCT
asodahs-134	38	1	_	_	PUNCT
asodahs-134	39	1	_	_	PUNCT
asodahs-134	40	1	_	_	PUNCT
asodahs-134	41	1	_	_	PUNCT
asodahs-134	42	1	_	_	PUNCT
asodahs-134	43	1	_	_	PUNCT
asodahs-134	44	1	_	_	PUNCT
asodahs-134	45	1	_	_	PUNCT
asodahs-134	46	1	_	_	PUNCT
asodahs-134	47	1	_	_	PUNCT
asodahs-134	47	2	article	article	NOUN
asodahs-134	47	3	history	history	NOUN
asodahs-134	47	4	:	:	PUNCT
asodahs-134	47	5	received	receive	VERB
asodahs-134	47	6	09	09	NUM
asodahs-134	47	7	may	may	AUX
asodahs-134	47	8	2025	2025	NUM
asodahs-134	47	9	reviewed	review	VERB
asodahs-134	47	10	29	29	NUM
asodahs-134	47	11	may	may	AUX
asodahs-134	47	12	2025	2025	NUM
asodahs-134	47	13	accepted	accept	VERB
asodahs-134	47	14	18	18	NUM
asodahs-134	47	15	june	june	PROPN
asodahs-134	47	16	2025	2025	NUM
asodahs-134	47	17	published	publish	VERB
asodahs-134	47	18	15	15	NUM
asodahs-134	47	19	sep	sep	NOUN
asodahs-134	47	20	2025	2025	NUM
asodahs-134	47	21	_	_	PUNCT
asodahs-134	48	1	_	_	PUNCT
asodahs-134	49	1	_	_	PUNCT
asodahs-134	50	1	_	_	PUNCT
asodahs-134	51	1	_	_	PUNCT
asodahs-134	52	1	_	_	PUNCT
asodahs-134	53	1	_	_	PUNCT
asodahs-134	54	1	_	_	PUNCT
asodahs-134	55	1	_	_	PUNCT
asodahs-134	56	1	_	_	PUNCT
asodahs-134	57	1	_	_	PUNCT
asodahs-134	58	1	_	_	PUNCT
asodahs-134	59	1	_	_	PUNCT
asodahs-134	60	1	_	_	PUNCT
asodahs-134	61	1	_	_	PUNCT
asodahs-134	62	1	_	_	PUNCT
asodahs-134	63	1	_	_	PUNCT
asodahs-134	64	1	_	_	PUNCT
asodahs-134	65	1	_	_	PUNCT
asodahs-134	66	1	_	_	PUNCT
asodahs-134	67	1	_	_	PUNCT
asodahs-134	68	1	_	_	PUNCT
asodahs-134	69	1	_	_	PUNCT
asodahs-134	70	1	_	_	PUNCT
asodahs-134	71	1	_	_	PUNCT
asodahs-134	72	1	_	_	PUNCT
asodahs-134	73	1	_	_	PUNCT
asodahs-134	74	1	_	_	PUNCT
asodahs-134	75	1	_	_	PUNCT
asodahs-134	76	1	_	_	PUNCT
asodahs-134	77	1	_	_	PUNCT
asodahs-134	78	1	_	_	PUNCT
asodahs-134	79	1	_	_	PUNCT
asodahs-134	80	1	_	_	PUNCT
asodahs-134	81	1	_	_	PUNCT
asodahs-134	82	1	_	_	PUNCT
asodahs-134	83	1	_	_	PUNCT
asodahs-134	84	1	_	_	PUNCT
asodahs-134	85	1	_	_	PUNCT
asodahs-134	86	1	_	_	PUNCT
asodahs-134	87	1	_	_	PUNCT
asodahs-134	88	1	_	_	PUNCT
asodahs-134	89	1	_	_	PUNCT
asodahs-134	90	1	_	_	PUNCT
asodahs-134	91	1	_	_	PUNCT
asodahs-134	91	2	cite	cite	VERB
asodahs-134	91	3	this	this	DET
asodahs-134	91	4	article	article	NOUN
asodahs-134	91	5	as	as	ADP
asodahs-134	91	6	:	:	PUNCT
asodahs-134	91	7	obeagu	obeagu	ADJ
asodahs-134	91	8	ei	ei	PROPN
asodahs-134	91	9	,	,	PUNCT
asodahs-134	91	10	nitric	nitric	ADJ
asodahs-134	91	11	oxide	oxide	NOUN
asodahs-134	91	12	bioavailability	bioavailability	NOUN
asodahs-134	91	13	and	and	CCONJ
asodahs-134	91	14	vascular	vascular	ADJ
asodahs-134	91	15	dysfunction	dysfunction	NOUN
asodahs-134	91	16	in	in	ADP
asodahs-134	91	17	sickle	sickle	NOUN
asodahs-134	91	18	cell	cell	NOUN
asodahs-134	91	19	patients	patient	NOUN
asodahs-134	91	20	:	:	PUNCT
asodahs-134	91	21	a	a	DET
asodahs-134	91	22	pathophysiological	pathophysiological	ADJ
asodahs-134	91	23	nexus	nexus	NOUN
asodahs-134	91	24	,	,	PUNCT
asodahs-134	91	25	asian	asian	ADJ
asodahs-134	91	26	journal	journal	NOUN
asodahs-134	91	27	of	of	ADP
asodahs-134	91	28	dental	dental	ADJ
asodahs-134	91	29	and	and	CCONJ
asodahs-134	91	30	health	health	NOUN
asodahs-134	91	31	sciences	science	NOUN
asodahs-134	91	32	.	.	PUNCT
asodahs-134	92	1	2025	2025	NUM
asodahs-134	92	2	;	;	PUNCT
asodahs-134	92	3	5(3):6	5(3):6	NUM
asodahs-134	92	4	-	-	SYM
asodahs-134	92	5	12	12	NUM
asodahs-134	92	6	doi	doi	NOUN
asodahs-134	92	7	:	:	PUNCT
asodahs-134	92	8	http://dx.doi.org/10.22270/ajdhs.v5i3.134	http://dx.doi.org/10.22270/ajdhs.v5i3.134	PROPN
asodahs-134	92	9	abstract	abstract	NOUN
asodahs-134	92	10	_	_	PUNCT
asodahs-134	93	1	_	_	PUNCT
asodahs-134	94	1	_	_	PUNCT
asodahs-134	95	1	_	_	PUNCT
asodahs-134	96	1	_	_	PUNCT
asodahs-134	97	1	_	_	PUNCT
asodahs-134	98	1	_	_	PUNCT
asodahs-134	99	1	_	_	PUNCT
asodahs-134	100	1	_	_	PUNCT
asodahs-134	101	1	_	_	PUNCT
asodahs-134	102	1	_	_	PUNCT
asodahs-134	103	1	_	_	PUNCT
asodahs-134	104	1	_	_	PUNCT
asodahs-134	105	1	_	_	PUNCT
asodahs-134	106	1	_	_	PUNCT
asodahs-134	107	1	_	_	PUNCT
asodahs-134	108	1	_	_	PUNCT
asodahs-134	109	1	_	_	PUNCT
asodahs-134	110	1	_	_	PUNCT
asodahs-134	111	1	_	_	PUNCT
asodahs-134	112	1	_	_	PUNCT
asodahs-134	113	1	_	_	PUNCT
asodahs-134	114	1	_	_	PUNCT
asodahs-134	115	1	_	_	PUNCT
asodahs-134	116	1	_	_	PUNCT
asodahs-134	117	1	_	_	PUNCT
asodahs-134	118	1	_	_	PUNCT
asodahs-134	119	1	_	_	PUNCT
asodahs-134	120	1	_	_	PUNCT
asodahs-134	121	1	_	_	PUNCT
asodahs-134	122	1	_	_	PUNCT
asodahs-134	123	1	_	_	PUNCT
asodahs-134	124	1	_	_	PUNCT
asodahs-134	125	1	_	_	PUNCT
asodahs-134	126	1	_	_	PUNCT
asodahs-134	127	1	_	_	PUNCT
asodahs-134	128	1	_	_	PUNCT
asodahs-134	129	1	_	_	PUNCT
asodahs-134	130	1	_	_	PUNCT
asodahs-134	131	1	_	_	PUNCT
asodahs-134	132	1	_	_	PUNCT
asodahs-134	133	1	_	_	PUNCT
asodahs-134	134	1	_	_	PUNCT
asodahs-134	135	1	_	_	PUNCT
asodahs-134	136	1	_	_	PUNCT
asodahs-134	137	1	_	_	PUNCT
asodahs-134	138	1	_	_	PUNCT
asodahs-134	139	1	_	_	PUNCT
asodahs-134	140	1	_	_	PUNCT
asodahs-134	141	1	_	_	PUNCT
asodahs-134	142	1	_	_	PUNCT
asodahs-134	143	1	_	_	PUNCT
asodahs-134	144	1	_	_	PUNCT
asodahs-134	145	1	_	_	PUNCT
asodahs-134	146	1	_	_	PUNCT
asodahs-134	147	1	_	_	PUNCT
asodahs-134	148	1	_	_	PUNCT
asodahs-134	149	1	_	_	PUNCT
asodahs-134	150	1	_	_	PUNCT
asodahs-134	151	1	_	_	PUNCT
asodahs-134	152	1	_	_	PUNCT
asodahs-134	153	1	_	_	PUNCT
asodahs-134	154	1	_	_	PUNCT
asodahs-134	155	1	_	_	PUNCT
asodahs-134	156	1	_	_	PUNCT
asodahs-134	157	1	_	_	PUNCT
asodahs-134	158	1	_	_	PUNCT
asodahs-134	159	1	_	_	PUNCT
asodahs-134	160	1	_	_	PUNCT
asodahs-134	161	1	_	_	PUNCT
asodahs-134	162	1	_	_	PUNCT
asodahs-134	163	1	_	_	PUNCT
asodahs-134	164	1	_	_	PUNCT
asodahs-134	165	1	_	_	PUNCT
asodahs-134	166	1	_	_	PUNCT
asodahs-134	167	1	_	_	PUNCT
asodahs-134	168	1	_	_	PUNCT
asodahs-134	169	1	_	_	PUNCT
asodahs-134	170	1	_	_	PUNCT
asodahs-134	171	1	_	_	PUNCT
asodahs-134	172	1	_	_	PUNCT
asodahs-134	173	1	_	_	PUNCT
asodahs-134	174	1	_	_	PUNCT
asodahs-134	175	1	_	_	PUNCT
asodahs-134	176	1	_	_	PUNCT
asodahs-134	177	1	_	_	PUNCT
asodahs-134	178	1	_	_	PUNCT
asodahs-134	179	1	_	_	PUNCT
asodahs-134	180	1	_	_	PUNCT
asodahs-134	181	1	_	_	PUNCT
asodahs-134	182	1	_	_	PUNCT
asodahs-134	183	1	_	_	PUNCT
asodahs-134	184	1	_	_	PUNCT
asodahs-134	185	1	_	_	PUNCT
asodahs-134	186	1	_	_	PUNCT
asodahs-134	187	1	_	_	PUNCT
asodahs-134	188	1	_	_	PUNCT
asodahs-134	189	1	_	_	PUNCT
asodahs-134	190	1	_	_	PUNCT
asodahs-134	191	1	_	_	PUNCT
asodahs-134	192	1	_	_	PUNCT
asodahs-134	193	1	_	_	PUNCT
asodahs-134	194	1	_	_	PUNCT
asodahs-134	195	1	_	_	PUNCT
asodahs-134	196	1	_	_	PUNCT
asodahs-134	197	1	_	_	PUNCT
asodahs-134	198	1	_	_	PUNCT
asodahs-134	199	1	_	_	PUNCT
asodahs-134	200	1	_	_	PUNCT
asodahs-134	201	1	_	_	PUNCT
asodahs-134	202	1	_	_	PUNCT
asodahs-134	203	1	_	_	PUNCT
asodahs-134	203	2	_	_	PUNCT
asodahs-134	203	3	sickle	sickle	NOUN
asodahs-134	203	4	cell	cell	NOUN
asodahs-134	203	5	disease	disease	NOUN
asodahs-134	203	6	(	(	PUNCT
asodahs-134	203	7	scd	scd	NOUN
asodahs-134	203	8	)	)	PUNCT
asodahs-134	203	9	is	be	AUX
asodahs-134	203	10	a	a	DET
asodahs-134	203	11	genetic	genetic	ADJ
asodahs-134	203	12	disorder	disorder	NOUN
asodahs-134	203	13	characterized	characterize	VERB
asodahs-134	203	14	by	by	ADP
asodahs-134	203	15	chronic	chronic	ADJ
asodahs-134	203	16	hemolytic	hemolytic	ADJ
asodahs-134	203	17	anemia	anemia	NOUN
asodahs-134	203	18	,	,	PUNCT
asodahs-134	203	19	recurrent	recurrent	ADJ
asodahs-134	203	20	vaso	vaso	NOUN
asodahs-134	203	21	-	-	PUNCT
asodahs-134	203	22	occlusive	occlusive	ADJ
asodahs-134	203	23	crises	crisis	NOUN
asodahs-134	203	24	,	,	PUNCT
asodahs-134	203	25	and	and	CCONJ
asodahs-134	203	26	progressive	progressive	ADJ
asodahs-134	203	27	organ	organ	NOUN
asodahs-134	203	28	damage	damage	NOUN
asodahs-134	203	29	.	.	PUNCT
asodahs-134	204	1	one	one	NUM
asodahs-134	204	2	of	of	ADP
asodahs-134	204	3	the	the	DET
asodahs-134	204	4	central	central	ADJ
asodahs-134	204	5	mechanisms	mechanism	NOUN
asodahs-134	204	6	driving	drive	VERB
asodahs-134	204	7	vascular	vascular	ADJ
asodahs-134	204	8	complications	complication	NOUN
asodahs-134	204	9	in	in	ADP
asodahs-134	204	10	scd	scd	PROPN
asodahs-134	204	11	is	be	AUX
asodahs-134	204	12	the	the	DET
asodahs-134	204	13	impaired	impaired	ADJ
asodahs-134	204	14	bioavailability	bioavailability	NOUN
asodahs-134	204	15	of	of	ADP
asodahs-134	204	16	nitric	nitric	ADJ
asodahs-134	204	17	oxide	oxide	NOUN
asodahs-134	204	18	(	(	PUNCT
asodahs-134	204	19	no	no	NOUN
asodahs-134	204	20	)	)	PUNCT
asodahs-134	204	21	,	,	PUNCT
asodahs-134	204	22	a	a	DET
asodahs-134	204	23	key	key	ADJ
asodahs-134	204	24	molecule	molecule	NOUN
asodahs-134	204	25	responsible	responsible	ADJ
asodahs-134	204	26	for	for	ADP
asodahs-134	204	27	regulating	regulate	VERB
asodahs-134	204	28	vascular	vascular	ADJ
asodahs-134	204	29	tone	tone	NOUN
asodahs-134	204	30	,	,	PUNCT
asodahs-134	204	31	inhibiting	inhibit	VERB
asodahs-134	204	32	platelet	platelet	NOUN
asodahs-134	204	33	aggregation	aggregation	NOUN
asodahs-134	204	34	,	,	PUNCT
asodahs-134	204	35	and	and	CCONJ
asodahs-134	204	36	maintaining	maintain	VERB
asodahs-134	204	37	endothelial	endothelial	ADJ
asodahs-134	204	38	integrity	integrity	NOUN
asodahs-134	204	39	.	.	PUNCT
asodahs-134	205	1	the	the	DET
asodahs-134	205	2	persistent	persistent	ADJ
asodahs-134	205	3	intravascular	intravascular	ADJ
asodahs-134	205	4	hemolysis	hemolysis	NOUN
asodahs-134	205	5	that	that	PRON
asodahs-134	205	6	occurs	occur	VERB
asodahs-134	205	7	in	in	ADP
asodahs-134	205	8	scd	scd	PROPN
asodahs-134	205	9	releases	release	NOUN
asodahs-134	205	10	free	free	ADJ
asodahs-134	205	11	hemoglobin	hemoglobin	NOUN
asodahs-134	205	12	and	and	CCONJ
asodahs-134	205	13	arginase	arginase	VERB
asodahs-134	205	14	into	into	ADP
asodahs-134	205	15	the	the	DET
asodahs-134	205	16	circulation	circulation	NOUN
asodahs-134	205	17	,	,	PUNCT
asodahs-134	205	18	which	which	PRON
asodahs-134	205	19	significantly	significantly	ADV
asodahs-134	205	20	reduces	reduce	VERB
asodahs-134	205	21	no	no	DET
asodahs-134	205	22	levels	level	NOUN
asodahs-134	205	23	and	and	CCONJ
asodahs-134	205	24	limits	limit	VERB
asodahs-134	205	25	its	its	PRON
asodahs-134	205	26	physiological	physiological	ADJ
asodahs-134	205	27	effects	effect	NOUN
asodahs-134	205	28	.	.	PUNCT
asodahs-134	206	1	reduced	reduce	VERB
asodahs-134	206	2	no	no	DET
asodahs-134	206	3	availability	availability	NOUN
asodahs-134	206	4	leads	lead	VERB
asodahs-134	206	5	to	to	ADP
asodahs-134	206	6	endothelial	endothelial	ADJ
asodahs-134	206	7	dysfunction	dysfunction	NOUN
asodahs-134	206	8	,	,	PUNCT
asodahs-134	206	9	characterized	characterize	VERB
asodahs-134	206	10	by	by	ADP
asodahs-134	206	11	vasoconstriction	vasoconstriction	NOUN
asodahs-134	206	12	,	,	PUNCT
asodahs-134	206	13	increased	increase	VERB
asodahs-134	206	14	leukocyte	leukocyte	NOUN
asodahs-134	206	15	adhesion	adhesion	NOUN
asodahs-134	206	16	,	,	PUNCT
asodahs-134	206	17	and	and	CCONJ
asodahs-134	206	18	a	a	DET
asodahs-134	206	19	pro	pro	ADJ
asodahs-134	206	20	-	-	ADJ
asodahs-134	206	21	thrombotic	thrombotic	ADJ
asodahs-134	206	22	state	state	NOUN
asodahs-134	206	23	.	.	PUNCT
asodahs-134	207	1	these	these	DET
asodahs-134	207	2	vascular	vascular	ADJ
asodahs-134	207	3	changes	change	NOUN
asodahs-134	207	4	not	not	PART
asodahs-134	207	5	only	only	ADV
asodahs-134	207	6	contribute	contribute	VERB
asodahs-134	207	7	to	to	ADP
asodahs-134	207	8	acute	acute	ADJ
asodahs-134	207	9	events	event	NOUN
asodahs-134	207	10	such	such	ADJ
asodahs-134	207	11	as	as	ADP
asodahs-134	207	12	pain	pain	NOUN
asodahs-134	207	13	crises	crisis	NOUN
asodahs-134	207	14	and	and	CCONJ
asodahs-134	207	15	acute	acute	ADJ
asodahs-134	207	16	chest	chest	NOUN
asodahs-134	207	17	syndrome	syndrome	NOUN
asodahs-134	207	18	but	but	CCONJ
asodahs-134	207	19	also	also	ADV
asodahs-134	207	20	underlie	underlie	VERB
asodahs-134	207	21	long	long	ADJ
asodahs-134	207	22	-	-	PUNCT
asodahs-134	207	23	term	term	NOUN
asodahs-134	207	24	complications	complication	NOUN
asodahs-134	207	25	including	include	VERB
asodahs-134	207	26	pulmonary	pulmonary	ADJ
asodahs-134	207	27	hypertension	hypertension	NOUN
asodahs-134	207	28	,	,	PUNCT
asodahs-134	207	29	stroke	stroke	NOUN
asodahs-134	207	30	,	,	PUNCT
asodahs-134	207	31	and	and	CCONJ
asodahs-134	207	32	chronic	chronic	ADJ
asodahs-134	207	33	organ	organ	NOUN
asodahs-134	207	34	damage	damage	NOUN
asodahs-134	207	35	.	.	PUNCT
asodahs-134	208	1	oxidative	oxidative	ADJ
asodahs-134	208	2	stress	stress	NOUN
asodahs-134	208	3	and	and	CCONJ
asodahs-134	208	4	inflammation	inflammation	NOUN
asodahs-134	208	5	further	far	ADV
asodahs-134	208	6	disrupt	disrupt	VERB
asodahs-134	208	7	no	no	DET
asodahs-134	208	8	synthesis	synthesis	NOUN
asodahs-134	208	9	by	by	ADP
asodahs-134	208	10	impairing	impair	VERB
asodahs-134	208	11	endothelial	endothelial	ADJ
asodahs-134	208	12	nitric	nitric	ADJ
asodahs-134	208	13	oxide	oxide	NOUN
asodahs-134	208	14	synthase	synthase	NOUN
asodahs-134	208	15	(	(	PUNCT
asodahs-134	208	16	enos	eno	NOUN
asodahs-134	208	17	)	)	PUNCT
asodahs-134	208	18	activity	activity	NOUN
asodahs-134	208	19	and	and	CCONJ
asodahs-134	208	20	uncoupling	uncouple	VERB
asodahs-134	208	21	its	its	PRON
asodahs-134	208	22	function	function	NOUN
asodahs-134	208	23	,	,	PUNCT
asodahs-134	208	24	creating	create	VERB
asodahs-134	208	25	a	a	DET
asodahs-134	208	26	vicious	vicious	ADJ
asodahs-134	208	27	cycle	cycle	NOUN
asodahs-134	208	28	of	of	ADP
asodahs-134	208	29	vascular	vascular	ADJ
asodahs-134	208	30	injury	injury	NOUN
asodahs-134	208	31	.	.	PUNCT
asodahs-134	209	1	keywords	keyword	NOUN
asodahs-134	209	2	:	:	PUNCT
asodahs-134	209	3	nitric	nitric	ADJ
asodahs-134	209	4	oxide	oxide	NOUN
asodahs-134	209	5	,	,	PUNCT
asodahs-134	209	6	sickle	sickle	NOUN
asodahs-134	209	7	cell	cell	NOUN
asodahs-134	209	8	disease	disease	NOUN
asodahs-134	209	9	,	,	PUNCT
asodahs-134	209	10	vascular	vascular	ADJ
asodahs-134	209	11	dysfunction	dysfunction	NOUN
asodahs-134	209	12	,	,	PUNCT
asodahs-134	209	13	hemolysis	hemolysis	NOUN
asodahs-134	209	14	,	,	PUNCT
asodahs-134	209	15	endothelial	endothelial	ADJ
asodahs-134	209	16	health	health	NOUN
asodahs-134	209	17	*	*	NOUN
asodahs-134	209	18	address	address	NOUN
asodahs-134	209	19	for	for	ADP
asodahs-134	209	20	correspondence	correspondence	NOUN
asodahs-134	209	21	:	:	PUNCT
asodahs-134	209	22	emmanuel	emmanuel	PROPN
asodahs-134	209	23	ifeanyi	ifeanyi	PROPN
asodahs-134	209	24	obeagu	obeagu	PROPN
asodahs-134	209	25	,	,	PUNCT
asodahs-134	209	26	department	department	NOUN
asodahs-134	209	27	of	of	ADP
asodahs-134	209	28	biomedical	biomedical	ADJ
asodahs-134	209	29	and	and	CCONJ
asodahs-134	209	30	laboratory	laboratory	NOUN
asodahs-134	209	31	science	science	PROPN
asodahs-134	209	32	,	,	PUNCT
asodahs-134	209	33	africa	africa	PROPN
asodahs-134	209	34	university	university	PROPN
asodahs-134	209	35	,	,	PUNCT
asodahs-134	209	36	zimbabwe	zimbabwe	ADJ
asodahs-134	209	37	introduction	introduction	NOUN
asodahs-134	209	38	sickle	sickle	NOUN
asodahs-134	209	39	cell	cell	NOUN
asodahs-134	209	40	disease	disease	NOUN
asodahs-134	209	41	(	(	PUNCT
asodahs-134	209	42	scd	scd	NOUN
asodahs-134	209	43	)	)	PUNCT
asodahs-134	209	44	is	be	AUX
asodahs-134	209	45	a	a	DET
asodahs-134	209	46	hereditary	hereditary	ADJ
asodahs-134	209	47	blood	blood	NOUN
asodahs-134	209	48	disorder	disorder	NOUN
asodahs-134	209	49	characterized	characterize	VERB
asodahs-134	209	50	by	by	ADP
asodahs-134	209	51	the	the	DET
asodahs-134	209	52	production	production	NOUN
asodahs-134	209	53	of	of	ADP
asodahs-134	209	54	abnormal	abnormal	ADJ
asodahs-134	209	55	hemoglobin	hemoglobin	NOUN
asodahs-134	209	56	,	,	PUNCT
asodahs-134	209	57	known	know	VERB
asodahs-134	209	58	as	as	ADP
asodahs-134	209	59	hemoglobin	hemoglobin	NOUN
asodahs-134	209	60	s	s	PART
asodahs-134	209	61	(	(	PUNCT
asodahs-134	209	62	hbs	hbs	PROPN
asodahs-134	209	63	)	)	PUNCT
asodahs-134	209	64	.	.	PUNCT
asodahs-134	210	1	under	under	ADP
asodahs-134	210	2	low	low	ADJ
asodahs-134	210	3	oxygen	oxygen	NOUN
asodahs-134	210	4	conditions	condition	NOUN
asodahs-134	210	5	,	,	PUNCT
asodahs-134	210	6	hbs	hbs	PROPN
asodahs-134	210	7	polymerizes	polymerize	VERB
asodahs-134	210	8	,	,	PUNCT
asodahs-134	210	9	causing	cause	VERB
asodahs-134	210	10	red	red	ADJ
asodahs-134	210	11	blood	blood	NOUN
asodahs-134	210	12	cells	cell	NOUN
asodahs-134	210	13	(	(	PUNCT
asodahs-134	210	14	rbcs	rbc	NOUN
asodahs-134	210	15	)	)	PUNCT
asodahs-134	210	16	to	to	PART
asodahs-134	210	17	adopt	adopt	VERB
asodahs-134	210	18	a	a	DET
asodahs-134	210	19	sickled	sickled	ADJ
asodahs-134	210	20	shape	shape	NOUN
asodahs-134	210	21	,	,	PUNCT
asodahs-134	210	22	which	which	PRON
asodahs-134	210	23	results	result	VERB
asodahs-134	210	24	in	in	ADP
asodahs-134	210	25	vascular	vascular	ADJ
asodahs-134	210	26	occlusion	occlusion	NOUN
asodahs-134	210	27	and	and	CCONJ
asodahs-134	210	28	hemolysis	hemolysis	NOUN
asodahs-134	210	29	.	.	PUNCT
asodahs-134	211	1	these	these	DET
asodahs-134	211	2	sickled	sickle	VERB
asodahs-134	211	3	cells	cell	NOUN
asodahs-134	211	4	contribute	contribute	VERB
asodahs-134	211	5	to	to	ADP
asodahs-134	211	6	chronic	chronic	ADJ
asodahs-134	211	7	hemolytic	hemolytic	ADJ
asodahs-134	211	8	anemia	anemia	NOUN
asodahs-134	211	9	,	,	PUNCT
asodahs-134	211	10	recurrent	recurrent	ADJ
asodahs-134	211	11	vasoocclusive	vasoocclusive	ADJ
asodahs-134	211	12	episodes	episode	NOUN
asodahs-134	211	13	,	,	PUNCT
asodahs-134	211	14	and	and	CCONJ
asodahs-134	211	15	progressive	progressive	ADJ
asodahs-134	211	16	organ	organ	NOUN
asodahs-134	211	17	damage	damage	NOUN
asodahs-134	211	18	.	.	PUNCT
asodahs-134	212	1	vascular	vascular	ADJ
asodahs-134	212	2	dysfunction	dysfunction	NOUN
asodahs-134	212	3	is	be	AUX
asodahs-134	212	4	a	a	DET
asodahs-134	212	5	hallmark	hallmark	ADJ
asodahs-134	212	6	feature	feature	NOUN
asodahs-134	212	7	of	of	ADP
asodahs-134	212	8	scd	scd	NOUN
asodahs-134	212	9	,	,	PUNCT
asodahs-134	212	10	playing	play	VERB
asodahs-134	212	11	a	a	DET
asodahs-134	212	12	central	central	ADJ
asodahs-134	212	13	role	role	NOUN
asodahs-134	212	14	in	in	ADP
asodahs-134	212	15	the	the	DET
asodahs-134	212	16	development	development	NOUN
asodahs-134	212	17	of	of	ADP
asodahs-134	212	18	both	both	CCONJ
asodahs-134	212	19	acute	acute	ADJ
asodahs-134	212	20	and	and	CCONJ
asodahs-134	212	21	chronic	chronic	ADJ
asodahs-134	212	22	complications	complication	NOUN
asodahs-134	212	23	.	.	PUNCT
asodahs-134	213	1	among	among	ADP
asodahs-134	213	2	the	the	DET
asodahs-134	213	3	key	key	ADJ
asodahs-134	213	4	molecular	molecular	ADJ
asodahs-134	213	5	players	player	NOUN
asodahs-134	213	6	in	in	ADP
asodahs-134	213	7	vascular	vascular	ADJ
asodahs-134	213	8	homeostasis	homeostasis	NOUN
asodahs-134	213	9	is	be	AUX
asodahs-134	213	10	nitric	nitric	ADJ
asodahs-134	213	11	oxide	oxide	NOUN
asodahs-134	213	12	(	(	PUNCT
asodahs-134	213	13	no	no	NOUN
asodahs-134	213	14	)	)	PUNCT
asodahs-134	213	15	,	,	PUNCT
asodahs-134	213	16	a	a	DET
asodahs-134	213	17	potent	potent	ADJ
asodahs-134	213	18	vasodilator	vasodilator	NOUN
asodahs-134	213	19	and	and	CCONJ
asodahs-134	213	20	anti	anti	ADJ
asodahs-134	213	21	-	-	ADJ
asodahs-134	213	22	inflammatory	inflammatory	ADJ
asodahs-134	213	23	agent	agent	NOUN
asodahs-134	213	24	produced	produce	VERB
asodahs-134	213	25	by	by	ADP
asodahs-134	213	26	endothelial	endothelial	ADJ
asodahs-134	213	27	cells	cell	NOUN
asodahs-134	213	28	.	.	PUNCT
asodahs-134	214	1	however	however	ADV
asodahs-134	214	2	,	,	PUNCT
asodahs-134	214	3	in	in	ADP
asodahs-134	214	4	scd	scd	PROPN
asodahs-134	214	5	,	,	PUNCT
asodahs-134	214	6	the	the	DET
asodahs-134	214	7	bioavailability	bioavailability	NOUN
asodahs-134	214	8	of	of	ADP
asodahs-134	214	9	no	no	PRON
asodahs-134	214	10	is	be	AUX
asodahs-134	214	11	significantly	significantly	ADV
asodahs-134	214	12	reduced	reduce	VERB
asodahs-134	214	13	,	,	PUNCT
asodahs-134	214	14	contributing	contribute	VERB
asodahs-134	214	15	to	to	ADP
asodahs-134	214	16	the	the	DET
asodahs-134	214	17	pathogenesis	pathogenesis	NOUN
asodahs-134	214	18	of	of	ADP
asodahs-134	214	19	vascular	vascular	ADJ
asodahs-134	214	20	complications	complication	NOUN
asodahs-134	214	21	and	and	CCONJ
asodahs-134	214	22	poor	poor	ADJ
asodahs-134	214	23	clinical	clinical	ADJ
asodahs-134	214	24	outcomes	outcome	NOUN
asodahs-134	214	25	1	1	NUM
asodahs-134	214	26	-	-	SYM
asodahs-134	214	27	2	2	NUM
asodahs-134	214	28	.	.	PUNCT
asodahs-134	215	1	no	no	PRON
asodahs-134	215	2	is	be	AUX
asodahs-134	215	3	synthesized	synthesize	VERB
asodahs-134	215	4	in	in	ADP
asodahs-134	215	5	endothelial	endothelial	ADJ
asodahs-134	215	6	cells	cell	NOUN
asodahs-134	215	7	by	by	ADP
asodahs-134	215	8	endothelial	endothelial	ADJ
asodahs-134	215	9	nitric	nitric	ADJ
asodahs-134	215	10	oxide	oxide	NOUN
asodahs-134	215	11	synthase	synthase	NOUN
asodahs-134	215	12	(	(	PUNCT
asodahs-134	215	13	enos	enos	PROPN
asodahs-134	215	14	)	)	PUNCT
asodahs-134	215	15	using	use	VERB
asodahs-134	215	16	l	l	NOUN
asodahs-134	215	17	-	-	NOUN
asodahs-134	215	18	arginine	arginine	NOUN
asodahs-134	215	19	as	as	ADP
asodahs-134	215	20	a	a	DET
asodahs-134	215	21	substrate	substrate	NOUN
asodahs-134	215	22	.	.	PUNCT
asodahs-134	216	1	once	once	ADV
asodahs-134	216	2	produced	produce	VERB
asodahs-134	216	3	,	,	PUNCT
asodahs-134	216	4	no	no	DET
asodahs-134	216	5	diffuses	diffuse	NOUN
asodahs-134	216	6	into	into	ADP
asodahs-134	216	7	smooth	smooth	ADJ
asodahs-134	216	8	muscle	muscle	NOUN
asodahs-134	216	9	cells	cell	NOUN
asodahs-134	216	10	,	,	PUNCT
asodahs-134	216	11	where	where	SCONJ
asodahs-134	216	12	it	it	PRON
asodahs-134	216	13	activates	activate	VERB
asodahs-134	216	14	soluble	soluble	ADJ
asodahs-134	216	15	guanylate	guanylate	NOUN
asodahs-134	216	16	cyclase	cyclase	NOUN
asodahs-134	216	17	(	(	PUNCT
asodahs-134	216	18	sgc	sgc	PROPN
asodahs-134	216	19	)	)	PUNCT
asodahs-134	216	20	,	,	PUNCT
asodahs-134	216	21	leading	lead	VERB
asodahs-134	216	22	to	to	ADP
asodahs-134	216	23	the	the	DET
asodahs-134	216	24	production	production	NOUN
asodahs-134	216	25	of	of	ADP
asodahs-134	216	26	cyclic	cyclic	PROPN
asodahs-134	216	27	guanosine	guanosine	NOUN
asodahs-134	216	28	monophosphate	monophosphate	NOUN
asodahs-134	216	29	(	(	PUNCT
asodahs-134	216	30	cgmp	cgmp	PROPN
asodahs-134	216	31	)	)	PUNCT
asodahs-134	216	32	.	.	PUNCT
asodahs-134	217	1	this	this	DET
asodahs-134	217	2	process	process	NOUN
asodahs-134	217	3	induces	induce	VERB
asodahs-134	217	4	vasodilation	vasodilation	NOUN
asodahs-134	217	5	and	and	CCONJ
asodahs-134	217	6	maintains	maintain	VERB
asodahs-134	217	7	vascular	vascular	ADJ
asodahs-134	217	8	tone	tone	NOUN
asodahs-134	217	9	.	.	PUNCT
asodahs-134	218	1	furthermore	furthermore	ADV
asodahs-134	218	2	,	,	PUNCT
asodahs-134	218	3	no	no	PRON
asodahs-134	218	4	has	have	VERB
asodahs-134	218	5	anti	anti	ADJ
asodahs-134	218	6	-	-	ADJ
asodahs-134	218	7	thrombotic	thrombotic	ADJ
asodahs-134	218	8	and	and	CCONJ
asodahs-134	218	9	anti	anti	ADJ
asodahs-134	218	10	-	-	ADJ
asodahs-134	218	11	inflammatory	inflammatory	ADJ
asodahs-134	218	12	properties	property	NOUN
asodahs-134	218	13	,	,	PUNCT
asodahs-134	218	14	preventing	prevent	VERB
asodahs-134	218	15	the	the	DET
asodahs-134	218	16	adhesion	adhesion	NOUN
asodahs-134	218	17	of	of	ADP
asodahs-134	218	18	platelets	platelet	NOUN
asodahs-134	218	19	and	and	CCONJ
asodahs-134	218	20	leukocytes	leukocyte	NOUN
asodahs-134	218	21	to	to	ADP
asodahs-134	218	22	the	the	DET
asodahs-134	218	23	endothelium	endothelium	NOUN
asodahs-134	218	24	.	.	PUNCT
asodahs-134	219	1	in	in	ADP
asodahs-134	219	2	healthy	healthy	ADJ
asodahs-134	219	3	individuals	individual	NOUN
asodahs-134	219	4	,	,	PUNCT
asodahs-134	219	5	no	no	PRON
asodahs-134	219	6	maintains	maintain	VERB
asodahs-134	219	7	vascular	vascular	ADJ
asodahs-134	219	8	homeostasis	homeostasis	NOUN
asodahs-134	219	9	by	by	ADP
asodahs-134	219	10	regulating	regulate	VERB
asodahs-134	219	11	blood	blood	NOUN
asodahs-134	219	12	flow	flow	NOUN
asodahs-134	219	13	,	,	PUNCT
asodahs-134	219	14	reducing	reduce	VERB
asodahs-134	219	15	blood	blood	NOUN
asodahs-134	219	16	clotting	clotting	NOUN
asodahs-134	219	17	,	,	PUNCT
asodahs-134	219	18	and	and	CCONJ
asodahs-134	219	19	preventing	prevent	VERB
asodahs-134	219	20	endothelial	endothelial	ADJ
asodahs-134	219	21	dysfunction	dysfunction	NOUN
asodahs-134	219	22	.	.	PUNCT
asodahs-134	220	1	however	however	ADV
asodahs-134	220	2	,	,	PUNCT
asodahs-134	220	3	in	in	ADP
asodahs-134	220	4	scd	scd	PROPN
asodahs-134	220	5	,	,	PUNCT
asodahs-134	220	6	no	no	DET
asodahs-134	220	7	’s	’s	ADV
asodahs-134	220	8	crucial	crucial	ADJ
asodahs-134	220	9	role	role	NOUN
asodahs-134	220	10	is	be	AUX
asodahs-134	220	11	impaired	impair	VERB
asodahs-134	220	12	by	by	ADP
asodahs-134	220	13	multiple	multiple	ADJ
asodahs-134	220	14	pathophysiological	pathophysiological	ADJ
asodahs-134	220	15	factors	factor	NOUN
asodahs-134	220	16	,	,	PUNCT
asodahs-134	220	17	leading	lead	VERB
asodahs-134	220	18	to	to	ADP
asodahs-134	220	19	significant	significant	ADJ
asodahs-134	220	20	consequences	consequence	NOUN
asodahs-134	220	21	for	for	ADP
asodahs-134	220	22	vascular	vascular	ADJ
asodahs-134	220	23	health	health	NOUN
asodahs-134	220	24	34	34	NUM
asodahs-134	220	25	.	.	PUNCT
asodahs-134	221	1	one	one	NUM
asodahs-134	221	2	of	of	ADP
asodahs-134	221	3	the	the	DET
asodahs-134	221	4	primary	primary	ADJ
asodahs-134	221	5	contributors	contributor	NOUN
asodahs-134	221	6	to	to	ADP
asodahs-134	221	7	no	no	DET
asodahs-134	221	8	depletion	depletion	NOUN
asodahs-134	221	9	in	in	ADP
asodahs-134	221	10	scd	scd	PROPN
asodahs-134	221	11	is	be	AUX
asodahs-134	221	12	the	the	DET
asodahs-134	221	13	chronic	chronic	ADJ
asodahs-134	221	14	hemolysis	hemolysis	NOUN
asodahs-134	221	15	of	of	ADP
asodahs-134	221	16	sickled	sickled	ADJ
asodahs-134	221	17	red	red	ADJ
asodahs-134	221	18	blood	blood	NOUN
asodahs-134	221	19	cells	cell	NOUN
asodahs-134	221	20	.	.	PUNCT
asodahs-134	222	1	the	the	DET
asodahs-134	222	2	release	release	NOUN
asodahs-134	222	3	of	of	ADP
asodahs-134	222	4	free	free	ADJ
asodahs-134	222	5	hemoglobin	hemoglobin	NOUN
asodahs-134	222	6	from	from	ADP
asodahs-134	222	7	lysed	lysed	ADJ
asodahs-134	222	8	rbcs	rbc	NOUN
asodahs-134	222	9	into	into	ADP
asodahs-134	222	10	the	the	DET
asodahs-134	222	11	bloodstream	bloodstream	NOUN
asodahs-134	222	12	leads	lead	VERB
asodahs-134	222	13	to	to	ADP
asodahs-134	222	14	an	an	DET
asodahs-134	222	15	increase	increase	NOUN
asodahs-134	222	16	in	in	ADP
asodahs-134	222	17	cell	cell	NOUN
asodahs-134	222	18	-	-	PUNCT
asodahs-134	222	19	free	free	ADJ
asodahs-134	222	20	hemoglobin	hemoglobin	NOUN
asodahs-134	222	21	levels	level	NOUN
asodahs-134	222	22	,	,	PUNCT
asodahs-134	222	23	which	which	PRON
asodahs-134	222	24	can	can	AUX
asodahs-134	222	25	bind	bind	VERB
asodahs-134	222	26	to	to	ADP
asodahs-134	222	27	and	and	CCONJ
asodahs-134	222	28	scavenge	scavenge	VERB
asodahs-134	222	29	no	no	INTJ
asodahs-134	222	30	.	.	PUNCT
asodahs-134	223	1	this	this	DET
asodahs-134	223	2	results	result	VERB
asodahs-134	223	3	in	in	ADP
asodahs-134	223	4	the	the	DET
asodahs-134	223	5	rapid	rapid	ADJ
asodahs-134	223	6	inactivation	inactivation	NOUN
asodahs-134	223	7	of	of	ADP
asodahs-134	223	8	no	no	PRON
asodahs-134	223	9	,	,	PUNCT
asodahs-134	223	10	thereby	thereby	ADV
asodahs-134	223	11	reducing	reduce	VERB
asodahs-134	223	12	its	its	PRON
asodahs-134	223	13	bioavailability	bioavailability	NOUN
asodahs-134	223	14	and	and	CCONJ
asodahs-134	223	15	function	function	NOUN
asodahs-134	223	16	.	.	PUNCT
asodahs-134	224	1	furthermore	furthermore	ADV
asodahs-134	224	2	,	,	PUNCT
asodahs-134	224	3	the	the	DET
asodahs-134	224	4	presence	presence	NOUN
asodahs-134	224	5	of	of	ADP
asodahs-134	224	6	free	free	ADJ
asodahs-134	224	7	hemoglobin	hemoglobin	NOUN
asodahs-134	224	8	promotes	promote	VERB
asodahs-134	224	9	oxidative	oxidative	ADJ
asodahs-134	224	10	stress	stress	NOUN
asodahs-134	224	11	,	,	PUNCT
asodahs-134	224	12	which	which	PRON
asodahs-134	224	13	further	far	ADV
asodahs-134	224	14	damages	damage	VERB
asodahs-134	224	15	the	the	DET
asodahs-134	224	16	endothelium	endothelium	NOUN
asodahs-134	224	17	and	and	CCONJ
asodahs-134	224	18	reduces	reduce	VERB
asodahs-134	224	19	the	the	DET
asodahs-134	224	20	activity	activity	NOUN
asodahs-134	224	21	of	of	ADP
asodahs-134	224	22	enos	eno	NOUN
asodahs-134	224	23	,	,	PUNCT
asodahs-134	224	24	the	the	DET
asodahs-134	224	25	enzyme	enzyme	NOUN
asodahs-134	224	26	responsible	responsible	ADJ
asodahs-134	224	27	for	for	ADP
asodahs-134	224	28	no	no	DET
asodahs-134	224	29	production	production	NOUN
asodahs-134	224	30	.	.	PUNCT
asodahs-134	225	1	as	as	ADP
asodahs-134	225	2	a	a	DET
asodahs-134	225	3	result	result	NOUN
asodahs-134	225	4	,	,	PUNCT
asodahs-134	225	5	the	the	DET
asodahs-134	225	6	normal	normal	ADJ
asodahs-134	225	7	vasodilatory	vasodilatory	ADJ
asodahs-134	225	8	effect	effect	NOUN
asodahs-134	225	9	of	of	ADP
asodahs-134	225	10	no	no	PRON
asodahs-134	225	11	is	be	AUX
asodahs-134	225	12	diminished	diminish	VERB
asodahs-134	225	13	,	,	PUNCT
asodahs-134	225	14	contributing	contribute	VERB
asodahs-134	225	15	to	to	ADP
asodahs-134	225	16	a	a	DET
asodahs-134	225	17	state	state	NOUN
asodahs-134	225	18	of	of	ADP
asodahs-134	225	19	endothelial	endothelial	ADJ
asodahs-134	225	20	dysfunction	dysfunction	NOUN
asodahs-134	225	21	that	that	PRON
asodahs-134	225	22	predisposes	predispose	VERB
asodahs-134	225	23	individuals	individual	NOUN
asodahs-134	225	24	with	with	ADP
asodahs-134	225	25	scd	scd	PROPN
asodahs-134	225	26	to	to	ADP
asodahs-134	225	27	vaso	vaso	PROPN
asodahs-134	225	28	-	-	PUNCT
asodahs-134	225	29	occlusive	occlusive	ADJ
asodahs-134	225	30	crises	crisis	NOUN
asodahs-134	225	31	and	and	CCONJ
asodahs-134	225	32	other	other	ADJ
asodahs-134	225	33	cardiovascular	cardiovascular	ADJ
asodahs-134	225	34	complications	complication	NOUN
asodahs-134	225	35	5	5	NUM
asodahs-134	225	36	.	.	PUNCT
asodahs-134	226	1	in	in	ADP
asodahs-134	226	2	addition	addition	NOUN
asodahs-134	226	3	to	to	ADP
asodahs-134	226	4	the	the	DET
asodahs-134	226	5	scavenging	scavenge	VERB
asodahs-134	226	6	effects	effect	NOUN
asodahs-134	226	7	of	of	ADP
asodahs-134	226	8	free	free	ADJ
asodahs-134	226	9	hemoglobin	hemoglobin	NOUN
asodahs-134	226	10	,	,	PUNCT
asodahs-134	226	11	the	the	DET
asodahs-134	226	12	activity	activity	NOUN
asodahs-134	226	13	of	of	ADP
asodahs-134	226	14	the	the	DET
asodahs-134	226	15	enzyme	enzyme	NOUN
asodahs-134	226	16	arginase	arginase	NOUN
asodahs-134	226	17	is	be	AUX
asodahs-134	226	18	significantly	significantly	ADV
asodahs-134	226	19	elevated	elevate	VERB
asodahs-134	226	20	in	in	ADP
asodahs-134	226	21	scd	scd	PROPN
asodahs-134	226	22	.	.	PUNCT
asodahs-134	227	1	arginase	arginase	PROPN
asodahs-134	227	2	competes	compete	VERB
asodahs-134	227	3	with	with	ADP
asodahs-134	227	4	endothelial	endothelial	ADJ
asodahs-134	227	5	nitric	nitric	ADJ
asodahs-134	227	6	oxide	oxide	NOUN
asodahs-134	227	7	synthase	synthase	NOUN
asodahs-134	227	8	(	(	PUNCT
asodahs-134	227	9	enos	enos	PROPN
asodahs-134	227	10	)	)	PUNCT
asodahs-134	227	11	for	for	ADP
asodahs-134	227	12	the	the	DET
asodahs-134	227	13	substrate	substrate	NOUN
asodahs-134	227	14	l	l	NOUN
asodahs-134	227	15	-	-	NOUN
asodahs-134	227	16	arginine	arginine	NOUN
asodahs-134	227	17	,	,	PUNCT
asodahs-134	227	18	a	a	DET
asodahs-134	227	19	key	key	ADJ
asodahs-134	227	20	precursor	precursor	NOUN
asodahs-134	227	21	in	in	ADP
asodahs-134	227	22	the	the	DET
asodahs-134	227	23	production	production	NOUN
asodahs-134	227	24	of	of	ADP
asodahs-134	227	25	no	no	PRON
asodahs-134	227	26	.	.	PUNCT
asodahs-134	228	1	increased	increase	VERB
asodahs-134	228	2	arginase	arginase	NOUN
asodahs-134	228	3	activity	activity	NOUN
asodahs-134	228	4	reduces	reduce	VERB
asodahs-134	228	5	the	the	DET
asodahs-134	228	6	availability	availability	NOUN
asodahs-134	228	7	of	of	ADP
asodahs-134	228	8	l	l	NOUN
asodahs-134	228	9	-	-	NOUN
asodahs-134	228	10	arginine	arginine	NOUN
asodahs-134	228	11	for	for	ADP
asodahs-134	228	12	no	no	DET
asodahs-134	228	13	synthesis	synthesis	NOUN
asodahs-134	228	14	,	,	PUNCT
asodahs-134	228	15	further	far	ADV
asodahs-134	228	16	exacerbating	exacerbate	VERB
asodahs-134	228	17	the	the	DET
asodahs-134	228	18	deficit	deficit	NOUN
asodahs-134	228	19	of	of	ADP
asodahs-134	228	20	no	no	PRON
asodahs-134	228	21	in	in	ADP
asodahs-134	228	22	the	the	DET
asodahs-134	228	23	open	open	ADJ
asodahs-134	228	24	access	access	NOUN
asodahs-134	228	25	review	review	NOUN
asodahs-134	228	26	article	article	NOUN
asodahs-134	228	27	http://jddtonline.info/	http://jddtonline.info/	NOUN
asodahs-134	228	28	http://dx.doi.org/10.22270/ajdhs.v5i3.134	http://dx.doi.org/10.22270/ajdhs.v5i3.134	PROPN
asodahs-134	228	29	https://crossmark.crossref.org/dialog/?doi=10.22270/ajdhs.v5i3.134&domain=pdf	https://crossmark.crossref.org/dialog/?doi=10.22270/ajdhs.v5i3.134&domain=pdf	PROPN
asodahs-134	228	30	https://orcid.org/0000-0002-4538-0161	https://orcid.org/0000-0002-4538-0161	PROPN
asodahs-134	228	31	emmanuel	emmanuel	PROPN
asodahs-134	228	32	ifeanyi	ifeanyi	PROPN
asodahs-134	228	33	obeagu	obeagu	PROPN
asodahs-134	228	34	asian	asian	PROPN
asodahs-134	228	35	journal	journal	PROPN
asodahs-134	228	36	of	of	ADP
asodahs-134	228	37	dental	dental	ADJ
asodahs-134	228	38	and	and	CCONJ
asodahs-134	228	39	health	health	NOUN
asodahs-134	228	40	sciences	science	NOUN
asodahs-134	228	41	.	.	PUNCT
asodahs-134	229	1	2025	2025	NUM
asodahs-134	229	2	;	;	PUNCT
asodahs-134	229	3	5(3):6	5(3):6	NUM
asodahs-134	229	4	-	-	SYM
asodahs-134	229	5	12	12	NUM
asodahs-134	229	6	[	[	X
asodahs-134	229	7	7	7	NUM
asodahs-134	229	8	]	]	PUNCT
asodahs-134	229	9	ajdhs.com	ajdhs.com	X
asodahs-134	229	10	vascular	vascular	ADJ
asodahs-134	229	11	system	system	NOUN
asodahs-134	229	12	.	.	PUNCT
asodahs-134	230	1	this	this	DET
asodahs-134	230	2	competition	competition	NOUN
asodahs-134	230	3	between	between	ADP
asodahs-134	230	4	arginase	arginase	NOUN
asodahs-134	230	5	and	and	CCONJ
asodahs-134	230	6	enos	enos	PROPN
asodahs-134	230	7	for	for	ADP
asodahs-134	230	8	l	l	NOUN
asodahs-134	230	9	-	-	NOUN
asodahs-134	230	10	arginine	arginine	NOUN
asodahs-134	230	11	is	be	AUX
asodahs-134	230	12	a	a	DET
asodahs-134	230	13	critical	critical	ADJ
asodahs-134	230	14	factor	factor	NOUN
asodahs-134	230	15	in	in	ADP
asodahs-134	230	16	the	the	DET
asodahs-134	230	17	pathophysiology	pathophysiology	NOUN
asodahs-134	230	18	of	of	ADP
asodahs-134	230	19	vascular	vascular	ADJ
asodahs-134	230	20	dysfunction	dysfunction	NOUN
asodahs-134	230	21	in	in	ADP
asodahs-134	230	22	scd	scd	PROPN
asodahs-134	230	23	,	,	PUNCT
asodahs-134	230	24	highlighting	highlight	VERB
asodahs-134	230	25	the	the	DET
asodahs-134	230	26	importance	importance	NOUN
asodahs-134	230	27	of	of	ADP
asodahs-134	230	28	understanding	understand	VERB
asodahs-134	230	29	how	how	SCONJ
asodahs-134	230	30	this	this	DET
asodahs-134	230	31	enzyme	enzyme	NOUN
asodahs-134	230	32	dysregulation	dysregulation	NOUN
asodahs-134	230	33	contributes	contribute	VERB
asodahs-134	230	34	to	to	ADP
asodahs-134	230	35	the	the	DET
asodahs-134	230	36	disease	disease	NOUN
asodahs-134	230	37	process	process	NOUN
asodahs-134	230	38	6	6	NUM
asodahs-134	230	39	-	-	SYM
asodahs-134	230	40	7	7	NUM
asodahs-134	230	41	.	.	PUNCT
asodahs-134	231	1	the	the	DET
asodahs-134	231	2	consequences	consequence	NOUN
asodahs-134	231	3	of	of	ADP
asodahs-134	231	4	reduced	reduce	VERB
asodahs-134	231	5	no	no	DET
asodahs-134	231	6	bioavailability	bioavailability	NOUN
asodahs-134	231	7	in	in	ADP
asodahs-134	231	8	scd	scd	PROPN
asodahs-134	231	9	are	be	AUX
asodahs-134	231	10	far	far	ADV
asodahs-134	231	11	-	-	PUNCT
asodahs-134	231	12	reaching	reach	VERB
asodahs-134	231	13	,	,	PUNCT
asodahs-134	231	14	extending	extend	VERB
asodahs-134	231	15	beyond	beyond	ADP
asodahs-134	231	16	the	the	DET
asodahs-134	231	17	immediate	immediate	ADJ
asodahs-134	231	18	effects	effect	NOUN
asodahs-134	231	19	of	of	ADP
asodahs-134	231	20	vasoconstriction	vasoconstriction	NOUN
asodahs-134	231	21	and	and	CCONJ
asodahs-134	231	22	platelet	platelet	NOUN
asodahs-134	231	23	aggregation	aggregation	NOUN
asodahs-134	231	24	.	.	PUNCT
asodahs-134	232	1	chronic	chronic	ADJ
asodahs-134	232	2	no	no	DET
asodahs-134	232	3	depletion	depletion	NOUN
asodahs-134	232	4	in	in	ADP
asodahs-134	232	5	scd	scd	PROPN
asodahs-134	232	6	promotes	promote	VERB
asodahs-134	232	7	endothelial	endothelial	ADJ
asodahs-134	232	8	activation	activation	NOUN
asodahs-134	232	9	,	,	PUNCT
asodahs-134	232	10	characterized	characterize	VERB
asodahs-134	232	11	by	by	ADP
asodahs-134	232	12	the	the	DET
asodahs-134	232	13	upregulation	upregulation	NOUN
asodahs-134	232	14	of	of	ADP
asodahs-134	232	15	adhesion	adhesion	NOUN
asodahs-134	232	16	molecules	molecule	NOUN
asodahs-134	232	17	such	such	ADJ
asodahs-134	232	18	as	as	ADP
asodahs-134	232	19	vcam-1	vcam-1	NUM
asodahs-134	232	20	and	and	CCONJ
asodahs-134	232	21	icam-1	icam-1	NUM
asodahs-134	232	22	.	.	PUNCT
asodahs-134	233	1	these	these	DET
asodahs-134	233	2	molecules	molecule	NOUN
asodahs-134	233	3	facilitate	facilitate	VERB
asodahs-134	233	4	the	the	DET
asodahs-134	233	5	adhesion	adhesion	NOUN
asodahs-134	233	6	of	of	ADP
asodahs-134	233	7	sickled	sickled	ADJ
asodahs-134	233	8	erythrocytes	erythrocyte	NOUN
asodahs-134	233	9	and	and	CCONJ
asodahs-134	233	10	leukocytes	leukocyte	NOUN
asodahs-134	233	11	to	to	ADP
asodahs-134	233	12	the	the	DET
asodahs-134	233	13	vascular	vascular	ADJ
asodahs-134	233	14	endothelium	endothelium	NOUN
asodahs-134	233	15	,	,	PUNCT
asodahs-134	233	16	leading	lead	VERB
asodahs-134	233	17	to	to	ADP
asodahs-134	233	18	further	further	ADJ
asodahs-134	233	19	obstruction	obstruction	NOUN
asodahs-134	233	20	of	of	ADP
asodahs-134	233	21	blood	blood	NOUN
asodahs-134	233	22	flow	flow	NOUN
asodahs-134	233	23	and	and	CCONJ
asodahs-134	233	24	exacerbating	exacerbate	VERB
asodahs-134	233	25	the	the	DET
asodahs-134	233	26	process	process	NOUN
asodahs-134	233	27	of	of	ADP
asodahs-134	233	28	vaso	vaso	NOUN
asodahs-134	233	29	-	-	PUNCT
asodahs-134	233	30	occlusion	occlusion	NOUN
asodahs-134	233	31	.	.	PUNCT
asodahs-134	234	1	moreover	moreover	ADV
asodahs-134	234	2	,	,	PUNCT
asodahs-134	234	3	the	the	DET
asodahs-134	234	4	reduced	reduce	VERB
asodahs-134	234	5	anti	anti	ADJ
asodahs-134	234	6	-	-	ADJ
asodahs-134	234	7	thrombotic	thrombotic	ADJ
asodahs-134	234	8	effect	effect	NOUN
asodahs-134	234	9	of	of	ADP
asodahs-134	234	10	no	no	DET
asodahs-134	234	11	increases	increase	NOUN
asodahs-134	234	12	the	the	DET
asodahs-134	234	13	risk	risk	NOUN
asodahs-134	234	14	of	of	ADP
asodahs-134	234	15	thrombus	thrombus	ADJ
asodahs-134	234	16	formation	formation	NOUN
asodahs-134	234	17	and	and	CCONJ
asodahs-134	234	18	deep	deep	ADJ
asodahs-134	234	19	vein	vein	ADJ
asodahs-134	234	20	thrombosis	thrombosis	NOUN
asodahs-134	234	21	.	.	PUNCT
asodahs-134	235	1	over	over	ADP
asodahs-134	235	2	time	time	NOUN
asodahs-134	235	3	,	,	PUNCT
asodahs-134	235	4	these	these	DET
asodahs-134	235	5	processes	process	NOUN
asodahs-134	235	6	contribute	contribute	VERB
asodahs-134	235	7	to	to	ADP
asodahs-134	235	8	the	the	DET
asodahs-134	235	9	development	development	NOUN
asodahs-134	235	10	of	of	ADP
asodahs-134	235	11	long	long	ADJ
asodahs-134	235	12	-	-	PUNCT
asodahs-134	235	13	term	term	NOUN
asodahs-134	235	14	vascular	vascular	ADJ
asodahs-134	235	15	complications	complication	NOUN
asodahs-134	235	16	,	,	PUNCT
asodahs-134	235	17	such	such	ADJ
asodahs-134	235	18	as	as	ADP
asodahs-134	235	19	pulmonary	pulmonary	ADJ
asodahs-134	235	20	hypertension	hypertension	NOUN
asodahs-134	235	21	,	,	PUNCT
asodahs-134	235	22	stroke	stroke	NOUN
asodahs-134	235	23	,	,	PUNCT
asodahs-134	235	24	and	and	CCONJ
asodahs-134	235	25	organ	organ	NOUN
asodahs-134	235	26	damage	damage	NOUN
asodahs-134	235	27	,	,	PUNCT
asodahs-134	235	28	particularly	particularly	ADV
asodahs-134	235	29	in	in	ADP
asodahs-134	235	30	the	the	DET
asodahs-134	235	31	lungs	lung	NOUN
asodahs-134	235	32	,	,	PUNCT
asodahs-134	235	33	kidneys	kidney	NOUN
asodahs-134	235	34	,	,	PUNCT
asodahs-134	235	35	and	and	CCONJ
asodahs-134	235	36	brain	brain	NOUN
asodahs-134	235	37	8	8	NUM
asodahs-134	235	38	-	-	SYM
asodahs-134	235	39	9	9	NUM
asodahs-134	235	40	.	.	NOUN
asodahs-134	235	41	nitric	nitric	ADJ
asodahs-134	235	42	oxide	oxide	NOUN
asodahs-134	235	43	and	and	CCONJ
asodahs-134	235	44	endothelial	endothelial	NOUN
asodahs-134	235	45	homeostasis	homeostasis	NOUN
asodahs-134	235	46	nitric	nitric	ADJ
asodahs-134	235	47	oxide	oxide	NOUN
asodahs-134	235	48	(	(	PUNCT
asodahs-134	235	49	no	no	NOUN
asodahs-134	235	50	)	)	PUNCT
asodahs-134	235	51	is	be	AUX
asodahs-134	235	52	a	a	DET
asodahs-134	235	53	pivotal	pivotal	ADJ
asodahs-134	235	54	signaling	signal	VERB
asodahs-134	235	55	molecule	molecule	NOUN
asodahs-134	235	56	that	that	PRON
asodahs-134	235	57	plays	play	VERB
asodahs-134	235	58	a	a	DET
asodahs-134	235	59	critical	critical	ADJ
asodahs-134	235	60	role	role	NOUN
asodahs-134	235	61	in	in	ADP
asodahs-134	235	62	maintaining	maintain	VERB
asodahs-134	235	63	endothelial	endothelial	ADJ
asodahs-134	235	64	homeostasis	homeostasis	NOUN
asodahs-134	235	65	,	,	PUNCT
asodahs-134	235	66	which	which	PRON
asodahs-134	235	67	is	be	AUX
asodahs-134	235	68	essential	essential	ADJ
asodahs-134	235	69	for	for	ADP
asodahs-134	235	70	vascular	vascular	ADJ
asodahs-134	235	71	health	health	NOUN
asodahs-134	235	72	.	.	PUNCT
asodahs-134	236	1	the	the	DET
asodahs-134	236	2	endothelial	endothelial	ADJ
asodahs-134	236	3	cells	cell	NOUN
asodahs-134	236	4	lining	line	VERB
asodahs-134	236	5	the	the	DET
asodahs-134	236	6	blood	blood	NOUN
asodahs-134	236	7	vessels	vessel	NOUN
asodahs-134	236	8	are	be	AUX
asodahs-134	236	9	responsible	responsible	ADJ
asodahs-134	236	10	for	for	ADP
asodahs-134	236	11	regulating	regulate	VERB
asodahs-134	236	12	vascular	vascular	ADJ
asodahs-134	236	13	tone	tone	NOUN
asodahs-134	236	14	,	,	PUNCT
asodahs-134	236	15	blood	blood	NOUN
asodahs-134	236	16	flow	flow	NOUN
asodahs-134	236	17	,	,	PUNCT
asodahs-134	236	18	and	and	CCONJ
asodahs-134	236	19	immune	immune	ADJ
asodahs-134	236	20	cell	cell	NOUN
asodahs-134	236	21	trafficking	trafficking	NOUN
asodahs-134	236	22	.	.	PUNCT
asodahs-134	237	1	these	these	DET
asodahs-134	237	2	cells	cell	NOUN
asodahs-134	237	3	continuously	continuously	ADV
asodahs-134	237	4	interact	interact	VERB
asodahs-134	237	5	with	with	ADP
asodahs-134	237	6	circulating	circulate	VERB
asodahs-134	237	7	blood	blood	NOUN
asodahs-134	237	8	components	component	NOUN
asodahs-134	237	9	,	,	PUNCT
asodahs-134	237	10	and	and	CCONJ
asodahs-134	237	11	no	no	PRON
asodahs-134	237	12	are	be	AUX
asodahs-134	237	13	central	central	ADJ
asodahs-134	237	14	to	to	ADP
asodahs-134	237	15	these	these	DET
asodahs-134	237	16	interactions	interaction	NOUN
asodahs-134	237	17	,	,	PUNCT
asodahs-134	237	18	ensuring	ensure	VERB
asodahs-134	237	19	that	that	SCONJ
asodahs-134	237	20	the	the	DET
asodahs-134	237	21	blood	blood	NOUN
asodahs-134	237	22	vessels	vessel	NOUN
asodahs-134	237	23	function	function	VERB
asodahs-134	237	24	properly	properly	ADV
asodahs-134	237	25	and	and	CCONJ
asodahs-134	237	26	that	that	SCONJ
asodahs-134	237	27	the	the	DET
asodahs-134	237	28	delicate	delicate	ADJ
asodahs-134	237	29	balance	balance	NOUN
asodahs-134	237	30	between	between	ADP
asodahs-134	237	31	vasodilation	vasodilation	NOUN
asodahs-134	237	32	and	and	CCONJ
asodahs-134	237	33	vasoconstriction	vasoconstriction	NOUN
asodahs-134	237	34	is	be	AUX
asodahs-134	237	35	maintained	maintain	VERB
asodahs-134	237	36	10	10	NUM
asodahs-134	237	37	.	.	PUNCT
asodahs-134	238	1	endothelial	endothelial	ADJ
asodahs-134	238	2	cells	cell	NOUN
asodahs-134	238	3	synthesize	synthesize	VERB
asodahs-134	238	4	no	no	ADV
asodahs-134	238	5	through	through	ADP
asodahs-134	238	6	the	the	DET
asodahs-134	238	7	action	action	NOUN
asodahs-134	238	8	of	of	ADP
asodahs-134	238	9	endothelial	endothelial	ADJ
asodahs-134	238	10	nitric	nitric	ADJ
asodahs-134	238	11	oxide	oxide	NOUN
asodahs-134	238	12	synthase	synthase	NOUN
asodahs-134	238	13	(	(	PUNCT
asodahs-134	238	14	enos	enos	PROPN
asodahs-134	238	15	)	)	PUNCT
asodahs-134	238	16	,	,	PUNCT
asodahs-134	238	17	which	which	PRON
asodahs-134	238	18	converts	convert	VERB
asodahs-134	238	19	l	l	NOUN
asodahs-134	238	20	-	-	NOUN
asodahs-134	238	21	arginine	arginine	NOUN
asodahs-134	238	22	into	into	ADP
asodahs-134	238	23	no	no	PRON
asodahs-134	238	24	in	in	ADP
asodahs-134	238	25	the	the	DET
asodahs-134	238	26	presence	presence	NOUN
asodahs-134	238	27	of	of	ADP
asodahs-134	238	28	oxygen	oxygen	NOUN
asodahs-134	238	29	.	.	PUNCT
asodahs-134	239	1	no	no	DET
asodahs-134	239	2	diffuses	diffuse	NOUN
asodahs-134	239	3	from	from	ADP
asodahs-134	239	4	the	the	DET
asodahs-134	239	5	endothelium	endothelium	NOUN
asodahs-134	239	6	into	into	ADP
asodahs-134	239	7	the	the	DET
asodahs-134	239	8	smooth	smooth	ADJ
asodahs-134	239	9	muscle	muscle	NOUN
asodahs-134	239	10	cells	cell	NOUN
asodahs-134	239	11	of	of	ADP
asodahs-134	239	12	the	the	DET
asodahs-134	239	13	blood	blood	NOUN
asodahs-134	239	14	vessel	vessel	NOUN
asodahs-134	239	15	walls	wall	NOUN
asodahs-134	239	16	,	,	PUNCT
asodahs-134	239	17	where	where	SCONJ
asodahs-134	239	18	it	it	PRON
asodahs-134	239	19	activates	activate	VERB
asodahs-134	239	20	soluble	soluble	ADJ
asodahs-134	239	21	guanylate	guanylate	NOUN
asodahs-134	239	22	cyclase	cyclase	NOUN
asodahs-134	239	23	(	(	PUNCT
asodahs-134	239	24	sgc	sgc	PROPN
asodahs-134	239	25	)	)	PUNCT
asodahs-134	239	26	.	.	PUNCT
asodahs-134	240	1	this	this	PRON
asodahs-134	240	2	leads	lead	VERB
asodahs-134	240	3	to	to	ADP
asodahs-134	240	4	the	the	DET
asodahs-134	240	5	generation	generation	NOUN
asodahs-134	240	6	of	of	ADP
asodahs-134	240	7	cyclic	cyclic	PROPN
asodahs-134	240	8	guanosine	guanosine	NOUN
asodahs-134	240	9	monophosphate	monophosphate	NOUN
asodahs-134	240	10	(	(	PUNCT
asodahs-134	240	11	cgmp	cgmp	PROPN
asodahs-134	240	12	)	)	PUNCT
asodahs-134	240	13	,	,	PUNCT
asodahs-134	240	14	a	a	DET
asodahs-134	240	15	secondary	secondary	ADJ
asodahs-134	240	16	messenger	messenger	NOUN
asodahs-134	240	17	that	that	PRON
asodahs-134	240	18	induces	induce	VERB
asodahs-134	240	19	vasodilation	vasodilation	NOUN
asodahs-134	240	20	by	by	ADP
asodahs-134	240	21	reducing	reduce	VERB
asodahs-134	240	22	intracellular	intracellular	ADJ
asodahs-134	240	23	calcium	calcium	NOUN
asodahs-134	240	24	levels	level	NOUN
asodahs-134	240	25	,	,	PUNCT
asodahs-134	240	26	thereby	thereby	ADV
asodahs-134	240	27	relaxing	relax	VERB
asodahs-134	240	28	the	the	DET
asodahs-134	240	29	smooth	smooth	ADJ
asodahs-134	240	30	muscle	muscle	NOUN
asodahs-134	240	31	cells	cell	NOUN
asodahs-134	240	32	.	.	PUNCT
asodahs-134	241	1	the	the	DET
asodahs-134	241	2	relaxation	relaxation	NOUN
asodahs-134	241	3	of	of	ADP
asodahs-134	241	4	smooth	smooth	ADJ
asodahs-134	241	5	muscle	muscle	NOUN
asodahs-134	241	6	results	result	NOUN
asodahs-134	241	7	in	in	ADP
asodahs-134	241	8	the	the	DET
asodahs-134	241	9	widening	widening	NOUN
asodahs-134	241	10	of	of	ADP
asodahs-134	241	11	the	the	DET
asodahs-134	241	12	blood	blood	NOUN
asodahs-134	241	13	vessels	vessel	NOUN
asodahs-134	241	14	(	(	PUNCT
asodahs-134	241	15	vasodilation	vasodilation	NOUN
asodahs-134	241	16	)	)	PUNCT
asodahs-134	241	17	,	,	PUNCT
asodahs-134	241	18	which	which	PRON
asodahs-134	241	19	lowers	lower	VERB
asodahs-134	241	20	vascular	vascular	ADJ
asodahs-134	241	21	resistance	resistance	NOUN
asodahs-134	241	22	and	and	CCONJ
asodahs-134	241	23	promotes	promote	VERB
asodahs-134	241	24	blood	blood	NOUN
asodahs-134	241	25	flow	flow	NOUN
asodahs-134	241	26	.	.	PUNCT
asodahs-134	242	1	this	this	DET
asodahs-134	242	2	process	process	NOUN
asodahs-134	242	3	is	be	AUX
asodahs-134	242	4	vital	vital	ADJ
asodahs-134	242	5	for	for	ADP
asodahs-134	242	6	regulating	regulate	VERB
asodahs-134	242	7	blood	blood	NOUN
asodahs-134	242	8	pressure	pressure	NOUN
asodahs-134	242	9	and	and	CCONJ
asodahs-134	242	10	ensuring	ensure	VERB
asodahs-134	242	11	that	that	SCONJ
asodahs-134	242	12	oxygen	oxygen	NOUN
asodahs-134	242	13	and	and	CCONJ
asodahs-134	242	14	nutrients	nutrient	NOUN
asodahs-134	242	15	are	be	AUX
asodahs-134	242	16	delivered	deliver	VERB
asodahs-134	242	17	efficiently	efficiently	ADV
asodahs-134	242	18	to	to	ADP
asodahs-134	242	19	tissues	tissue	NOUN
asodahs-134	242	20	throughout	throughout	ADP
asodahs-134	242	21	the	the	DET
asodahs-134	242	22	body	body	NOUN
asodahs-134	242	23	11	11	NUM
asodahs-134	242	24	-	-	SYM
asodahs-134	242	25	12	12	NUM
asodahs-134	242	26	.	.	PUNCT
asodahs-134	243	1	in	in	ADP
asodahs-134	243	2	addition	addition	NOUN
asodahs-134	243	3	to	to	ADP
asodahs-134	243	4	its	its	PRON
asodahs-134	243	5	vasodilatory	vasodilatory	ADJ
asodahs-134	243	6	effects	effect	NOUN
asodahs-134	243	7	,	,	PUNCT
asodahs-134	243	8	no	no	PRON
asodahs-134	243	9	has	have	VERB
asodahs-134	243	10	several	several	ADJ
asodahs-134	243	11	other	other	ADJ
asodahs-134	243	12	important	important	ADJ
asodahs-134	243	13	functions	function	NOUN
asodahs-134	243	14	in	in	ADP
asodahs-134	243	15	endothelial	endothelial	ADJ
asodahs-134	243	16	homeostasis	homeostasis	NOUN
asodahs-134	243	17	.	.	PUNCT
asodahs-134	244	1	it	it	PRON
asodahs-134	244	2	acts	act	VERB
asodahs-134	244	3	as	as	ADP
asodahs-134	244	4	an	an	DET
asodahs-134	244	5	anti	anti	ADJ
asodahs-134	244	6	-	-	ADJ
asodahs-134	244	7	inflammatory	inflammatory	ADJ
asodahs-134	244	8	agent	agent	NOUN
asodahs-134	244	9	by	by	ADP
asodahs-134	244	10	inhibiting	inhibit	VERB
asodahs-134	244	11	the	the	DET
asodahs-134	244	12	adhesion	adhesion	NOUN
asodahs-134	244	13	of	of	ADP
asodahs-134	244	14	leukocytes	leukocyte	NOUN
asodahs-134	244	15	to	to	ADP
asodahs-134	244	16	the	the	DET
asodahs-134	244	17	endothelial	endothelial	ADJ
asodahs-134	244	18	cells	cell	NOUN
asodahs-134	244	19	,	,	PUNCT
asodahs-134	244	20	which	which	PRON
asodahs-134	244	21	helps	help	VERB
asodahs-134	244	22	prevent	prevent	VERB
asodahs-134	244	23	excessive	excessive	ADJ
asodahs-134	244	24	inflammation	inflammation	NOUN
asodahs-134	244	25	and	and	CCONJ
asodahs-134	244	26	tissue	tissue	NOUN
asodahs-134	244	27	damage	damage	NOUN
asodahs-134	244	28	.	.	PUNCT
asodahs-134	245	1	furthermore	furthermore	ADV
asodahs-134	245	2	,	,	PUNCT
asodahs-134	245	3	no	no	PRON
asodahs-134	245	4	exerts	exert	VERB
asodahs-134	245	5	anti	anti	ADJ
asodahs-134	245	6	-	-	ADJ
asodahs-134	245	7	thrombotic	thrombotic	ADJ
asodahs-134	245	8	effects	effect	NOUN
asodahs-134	245	9	by	by	ADP
asodahs-134	245	10	inhibiting	inhibit	VERB
asodahs-134	245	11	platelet	platelet	NOUN
asodahs-134	245	12	aggregation	aggregation	NOUN
asodahs-134	245	13	and	and	CCONJ
asodahs-134	245	14	promoting	promote	VERB
asodahs-134	245	15	fibrinolysis	fibrinolysis	NOUN
asodahs-134	245	16	.	.	PUNCT
asodahs-134	246	1	this	this	PRON
asodahs-134	246	2	prevents	prevent	VERB
asodahs-134	246	3	the	the	DET
asodahs-134	246	4	formation	formation	NOUN
asodahs-134	246	5	of	of	ADP
asodahs-134	246	6	clots	clot	NOUN
asodahs-134	246	7	that	that	PRON
asodahs-134	246	8	could	could	AUX
asodahs-134	246	9	obstruct	obstruct	VERB
asodahs-134	246	10	blood	blood	NOUN
asodahs-134	246	11	vessels	vessel	NOUN
asodahs-134	246	12	and	and	CCONJ
asodahs-134	246	13	disrupt	disrupt	VERB
asodahs-134	246	14	blood	blood	NOUN
asodahs-134	246	15	flow	flow	NOUN
asodahs-134	246	16	.	.	PUNCT
asodahs-134	247	1	no	no	PRON
asodahs-134	247	2	also	also	ADV
asodahs-134	247	3	plays	play	VERB
asodahs-134	247	4	a	a	DET
asodahs-134	247	5	role	role	NOUN
asodahs-134	247	6	in	in	ADP
asodahs-134	247	7	regulating	regulate	VERB
asodahs-134	247	8	vascular	vascular	ADJ
asodahs-134	247	9	permeability	permeability	NOUN
asodahs-134	247	10	,	,	PUNCT
asodahs-134	247	11	ensuring	ensure	VERB
asodahs-134	247	12	that	that	SCONJ
asodahs-134	247	13	the	the	DET
asodahs-134	247	14	endothelial	endothelial	ADJ
asodahs-134	247	15	barrier	barrier	NOUN
asodahs-134	247	16	remains	remain	VERB
asodahs-134	247	17	intact	intact	ADJ
asodahs-134	247	18	to	to	PART
asodahs-134	247	19	prevent	prevent	VERB
asodahs-134	247	20	unwanted	unwanted	ADJ
asodahs-134	247	21	leakage	leakage	NOUN
asodahs-134	247	22	of	of	ADP
asodahs-134	247	23	plasma	plasma	NOUN
asodahs-134	247	24	proteins	protein	NOUN
asodahs-134	247	25	into	into	ADP
asodahs-134	247	26	tissues	tissue	NOUN
asodahs-134	247	27	13	13	NUM
asodahs-134	247	28	.	.	PUNCT
asodahs-134	248	1	however	however	ADV
asodahs-134	248	2	,	,	PUNCT
asodahs-134	248	3	the	the	DET
asodahs-134	248	4	bioavailability	bioavailability	NOUN
asodahs-134	248	5	of	of	ADP
asodahs-134	248	6	no	no	PRON
asodahs-134	248	7	can	can	AUX
asodahs-134	248	8	be	be	AUX
asodahs-134	248	9	compromised	compromise	VERB
asodahs-134	248	10	in	in	ADP
asodahs-134	248	11	various	various	ADJ
asodahs-134	248	12	pathological	pathological	ADJ
asodahs-134	248	13	conditions	condition	NOUN
asodahs-134	248	14	,	,	PUNCT
asodahs-134	248	15	including	include	VERB
asodahs-134	248	16	sickle	sickle	NOUN
asodahs-134	248	17	cell	cell	NOUN
asodahs-134	248	18	disease	disease	NOUN
asodahs-134	248	19	(	(	PUNCT
asodahs-134	248	20	scd	scd	NOUN
asodahs-134	248	21	)	)	PUNCT
asodahs-134	248	22	.	.	PUNCT
asodahs-134	249	1	in	in	ADP
asodahs-134	249	2	scd	scd	PROPN
asodahs-134	249	3	,	,	PUNCT
asodahs-134	249	4	a	a	DET
asodahs-134	249	5	combination	combination	NOUN
asodahs-134	249	6	of	of	ADP
asodahs-134	249	7	factors	factor	NOUN
asodahs-134	249	8	such	such	ADJ
asodahs-134	249	9	as	as	ADP
asodahs-134	249	10	increased	increase	VERB
asodahs-134	249	11	oxidative	oxidative	ADJ
asodahs-134	249	12	stress	stress	NOUN
asodahs-134	249	13	,	,	PUNCT
asodahs-134	249	14	chronic	chronic	ADJ
asodahs-134	249	15	hemolysis	hemolysis	NOUN
asodahs-134	249	16	,	,	PUNCT
asodahs-134	249	17	and	and	CCONJ
asodahs-134	249	18	the	the	DET
asodahs-134	249	19	release	release	NOUN
asodahs-134	249	20	of	of	ADP
asodahs-134	249	21	free	free	ADJ
asodahs-134	249	22	hemoglobin	hemoglobin	NOUN
asodahs-134	249	23	leads	lead	VERB
asodahs-134	249	24	to	to	ADP
asodahs-134	249	25	a	a	DET
asodahs-134	249	26	significant	significant	ADJ
asodahs-134	249	27	reduction	reduction	NOUN
asodahs-134	249	28	in	in	ADP
asodahs-134	249	29	no	no	DET
asodahs-134	249	30	levels	level	NOUN
asodahs-134	249	31	.	.	PUNCT
asodahs-134	250	1	free	free	ADJ
asodahs-134	250	2	hemoglobin	hemoglobin	NOUN
asodahs-134	250	3	,	,	PUNCT
asodahs-134	250	4	released	release	VERB
asodahs-134	250	5	from	from	ADP
asodahs-134	250	6	lysed	lyse	VERB
asodahs-134	250	7	red	red	ADJ
asodahs-134	250	8	blood	blood	NOUN
asodahs-134	250	9	cells	cell	NOUN
asodahs-134	250	10	,	,	PUNCT
asodahs-134	250	11	scavenges	scavenge	VERB
asodahs-134	250	12	no	no	ADV
asodahs-134	250	13	,	,	PUNCT
asodahs-134	250	14	reducing	reduce	VERB
asodahs-134	250	15	its	its	PRON
asodahs-134	250	16	availability	availability	NOUN
asodahs-134	250	17	and	and	CCONJ
asodahs-134	250	18	impairing	impair	VERB
asodahs-134	250	19	its	its	PRON
asodahs-134	250	20	vasodilatory	vasodilatory	ADJ
asodahs-134	250	21	effects	effect	NOUN
asodahs-134	250	22	.	.	PUNCT
asodahs-134	251	1	this	this	PRON
asodahs-134	251	2	contributes	contribute	VERB
asodahs-134	251	3	to	to	ADP
asodahs-134	251	4	endothelial	endothelial	ADJ
asodahs-134	251	5	dysfunction	dysfunction	NOUN
asodahs-134	251	6	,	,	PUNCT
asodahs-134	251	7	characterized	characterize	VERB
asodahs-134	251	8	by	by	ADP
asodahs-134	251	9	a	a	DET
asodahs-134	251	10	shift	shift	NOUN
asodahs-134	251	11	toward	toward	ADP
asodahs-134	251	12	vasoconstriction	vasoconstriction	NOUN
asodahs-134	251	13	,	,	PUNCT
asodahs-134	251	14	increased	increase	VERB
asodahs-134	251	15	leukocyte	leukocyte	NOUN
asodahs-134	251	16	adhesion	adhesion	NOUN
asodahs-134	251	17	,	,	PUNCT
asodahs-134	251	18	and	and	CCONJ
asodahs-134	251	19	a	a	DET
asodahs-134	251	20	pro	pro	ADJ
asodahs-134	251	21	-	-	ADJ
asodahs-134	251	22	thrombotic	thrombotic	ADJ
asodahs-134	251	23	state	state	NOUN
asodahs-134	251	24	.	.	PUNCT
asodahs-134	252	1	these	these	DET
asodahs-134	252	2	changes	change	NOUN
asodahs-134	252	3	underlie	underlie	VERB
asodahs-134	252	4	many	many	ADJ
asodahs-134	252	5	of	of	ADP
asodahs-134	252	6	the	the	DET
asodahs-134	252	7	vascular	vascular	ADJ
asodahs-134	252	8	complications	complication	NOUN
asodahs-134	252	9	seen	see	VERB
asodahs-134	252	10	in	in	ADP
asodahs-134	252	11	scd	scd	PROPN
asodahs-134	252	12	,	,	PUNCT
asodahs-134	252	13	including	include	VERB
asodahs-134	252	14	vasoocclusive	vasoocclusive	ADJ
asodahs-134	252	15	crises	crisis	NOUN
asodahs-134	252	16	,	,	PUNCT
asodahs-134	252	17	pulmonary	pulmonary	ADJ
asodahs-134	252	18	hypertension	hypertension	NOUN
asodahs-134	252	19	,	,	PUNCT
asodahs-134	252	20	and	and	CCONJ
asodahs-134	252	21	organ	organ	NOUN
asodahs-134	252	22	damage	damage	NOUN
asodahs-134	252	23	14	14	NUM
asodahs-134	252	24	-	-	SYM
asodahs-134	252	25	15	15	NUM
asodahs-134	252	26	.	.	PUNCT
asodahs-134	253	1	in	in	ADP
asodahs-134	253	2	addition	addition	NOUN
asodahs-134	253	3	to	to	ADP
asodahs-134	253	4	hemolysis	hemolysis	NOUN
asodahs-134	253	5	,	,	PUNCT
asodahs-134	253	6	other	other	ADJ
asodahs-134	253	7	factors	factor	NOUN
asodahs-134	253	8	contribute	contribute	VERB
asodahs-134	253	9	to	to	ADP
asodahs-134	253	10	no	no	DET
asodahs-134	253	11	depletion	depletion	NOUN
asodahs-134	253	12	in	in	ADP
asodahs-134	253	13	scd	scd	PROPN
asodahs-134	253	14	.	.	PROPN
asodahs-134	254	1	arginase	arginase	PROPN
asodahs-134	254	2	,	,	PUNCT
asodahs-134	254	3	an	an	DET
asodahs-134	254	4	enzyme	enzyme	NOUN
asodahs-134	254	5	that	that	PRON
asodahs-134	254	6	metabolizes	metabolize	VERB
asodahs-134	254	7	l	l	NOUN
asodahs-134	254	8	-	-	NOUN
asodahs-134	254	9	arginine	arginine	NOUN
asodahs-134	254	10	,	,	PUNCT
asodahs-134	254	11	the	the	DET
asodahs-134	254	12	precursor	precursor	NOUN
asodahs-134	254	13	for	for	ADP
asodahs-134	254	14	no	no	DET
asodahs-134	254	15	synthesis	synthesis	NOUN
asodahs-134	254	16	,	,	PUNCT
asodahs-134	254	17	is	be	AUX
asodahs-134	254	18	upregulated	upregulate	VERB
asodahs-134	254	19	in	in	ADP
asodahs-134	254	20	scd	scd	PROPN
asodahs-134	254	21	.	.	PUNCT
asodahs-134	255	1	this	this	DET
asodahs-134	255	2	results	result	VERB
asodahs-134	255	3	in	in	ADP
asodahs-134	255	4	a	a	DET
asodahs-134	255	5	competition	competition	NOUN
asodahs-134	255	6	for	for	ADP
asodahs-134	255	7	l	l	NOUN
asodahs-134	255	8	-	-	NOUN
asodahs-134	255	9	arginine	arginine	NOUN
asodahs-134	255	10	between	between	ADP
asodahs-134	255	11	arginase	arginase	NOUN
asodahs-134	255	12	and	and	CCONJ
asodahs-134	255	13	enos	eno	NOUN
asodahs-134	255	14	,	,	PUNCT
asodahs-134	255	15	further	far	ADV
asodahs-134	255	16	limiting	limit	VERB
asodahs-134	255	17	the	the	DET
asodahs-134	255	18	substrate	substrate	NOUN
asodahs-134	255	19	available	available	ADJ
asodahs-134	255	20	for	for	ADP
asodahs-134	255	21	no	no	DET
asodahs-134	255	22	production	production	NOUN
asodahs-134	255	23	.	.	PUNCT
asodahs-134	256	1	as	as	ADP
asodahs-134	256	2	a	a	DET
asodahs-134	256	3	result	result	NOUN
asodahs-134	256	4	,	,	PUNCT
asodahs-134	256	5	endothelial	endothelial	ADJ
asodahs-134	256	6	cells	cell	NOUN
asodahs-134	256	7	in	in	ADP
asodahs-134	256	8	scd	scd	PROPN
asodahs-134	256	9	patients	patient	NOUN
asodahs-134	256	10	are	be	AUX
asodahs-134	256	11	less	less	ADV
asodahs-134	256	12	capable	capable	ADJ
asodahs-134	256	13	of	of	ADP
asodahs-134	256	14	producing	produce	VERB
asodahs-134	256	15	no	no	NOUN
asodahs-134	256	16	,	,	PUNCT
asodahs-134	256	17	exacerbating	exacerbate	VERB
asodahs-134	256	18	endothelial	endothelial	ADJ
asodahs-134	256	19	dysfunction	dysfunction	NOUN
asodahs-134	256	20	and	and	CCONJ
asodahs-134	256	21	contributing	contribute	VERB
asodahs-134	256	22	to	to	ADP
asodahs-134	256	23	the	the	DET
asodahs-134	256	24	vascular	vascular	ADJ
asodahs-134	256	25	complications	complication	NOUN
asodahs-134	256	26	associated	associate	VERB
asodahs-134	256	27	with	with	ADP
asodahs-134	256	28	the	the	DET
asodahs-134	256	29	disease	disease	NOUN
asodahs-134	256	30	16	16	NUM
asodahs-134	256	31	.	.	PUNCT
asodahs-134	257	1	mechanisms	mechanism	NOUN
asodahs-134	257	2	of	of	ADP
asodahs-134	257	3	nitric	nitric	ADJ
asodahs-134	257	4	oxide	oxide	NOUN
asodahs-134	257	5	depletion	depletion	NOUN
asodahs-134	257	6	in	in	ADP
asodahs-134	257	7	sickle	sickle	NOUN
asodahs-134	257	8	cell	cell	NOUN
asodahs-134	257	9	disease	disease	NOUN
asodahs-134	257	10	(	(	PUNCT
asodahs-134	257	11	scd	scd	NOUN
asodahs-134	257	12	)	)	PUNCT
asodahs-134	257	13	in	in	ADP
asodahs-134	257	14	sickle	sickle	NOUN
asodahs-134	257	15	cell	cell	NOUN
asodahs-134	257	16	disease	disease	NOUN
asodahs-134	257	17	(	(	PUNCT
asodahs-134	257	18	scd	scd	NOUN
asodahs-134	257	19	)	)	PUNCT
asodahs-134	257	20	,	,	PUNCT
asodahs-134	257	21	the	the	DET
asodahs-134	257	22	bioavailability	bioavailability	NOUN
asodahs-134	257	23	of	of	ADP
asodahs-134	257	24	nitric	nitric	ADJ
asodahs-134	257	25	oxide	oxide	NOUN
asodahs-134	257	26	(	(	PUNCT
asodahs-134	257	27	no	no	NOUN
asodahs-134	257	28	)	)	PUNCT
asodahs-134	257	29	is	be	AUX
asodahs-134	257	30	significantly	significantly	ADV
asodahs-134	257	31	reduced	reduce	VERB
asodahs-134	257	32	,	,	PUNCT
asodahs-134	257	33	contributing	contribute	VERB
asodahs-134	257	34	to	to	PART
asodahs-134	257	35	vascular	vascular	ADJ
asodahs-134	257	36	dysfunction	dysfunction	NOUN
asodahs-134	257	37	,	,	PUNCT
asodahs-134	257	38	inflammation	inflammation	NOUN
asodahs-134	257	39	,	,	PUNCT
asodahs-134	257	40	and	and	CCONJ
asodahs-134	257	41	other	other	ADJ
asodahs-134	257	42	severe	severe	ADJ
asodahs-134	257	43	complications	complication	NOUN
asodahs-134	257	44	.	.	PUNCT
asodahs-134	258	1	several	several	ADJ
asodahs-134	258	2	interrelated	interrelated	ADJ
asodahs-134	258	3	mechanisms	mechanism	NOUN
asodahs-134	258	4	are	be	AUX
asodahs-134	258	5	responsible	responsible	ADJ
asodahs-134	258	6	for	for	ADP
asodahs-134	258	7	the	the	DET
asodahs-134	258	8	depletion	depletion	NOUN
asodahs-134	258	9	of	of	ADP
asodahs-134	258	10	no	no	PRON
asodahs-134	258	11	in	in	ADP
asodahs-134	258	12	scd	scd	PROPN
asodahs-134	258	13	,	,	PUNCT
asodahs-134	258	14	including	include	VERB
asodahs-134	258	15	chronic	chronic	ADJ
asodahs-134	258	16	hemolysis	hemolysis	NOUN
asodahs-134	258	17	,	,	PUNCT
asodahs-134	258	18	oxidative	oxidative	ADJ
asodahs-134	258	19	stress	stress	NOUN
asodahs-134	258	20	,	,	PUNCT
asodahs-134	258	21	upregulation	upregulation	NOUN
asodahs-134	258	22	of	of	ADP
asodahs-134	258	23	arginase	arginase	NOUN
asodahs-134	258	24	,	,	PUNCT
asodahs-134	258	25	and	and	CCONJ
asodahs-134	258	26	endothelial	endothelial	ADJ
asodahs-134	258	27	dysfunction	dysfunction	NOUN
asodahs-134	258	28	.	.	PUNCT
asodahs-134	259	1	these	these	DET
asodahs-134	259	2	mechanisms	mechanism	NOUN
asodahs-134	259	3	work	work	VERB
asodahs-134	259	4	synergistically	synergistically	ADV
asodahs-134	259	5	,	,	PUNCT
asodahs-134	259	6	creating	create	VERB
asodahs-134	259	7	a	a	DET
asodahs-134	259	8	vicious	vicious	ADJ
asodahs-134	259	9	cycle	cycle	NOUN
asodahs-134	259	10	that	that	PRON
asodahs-134	259	11	exacerbates	exacerbate	VERB
asodahs-134	259	12	the	the	DET
asodahs-134	259	13	clinical	clinical	ADJ
asodahs-134	259	14	manifestations	manifestation	NOUN
asodahs-134	259	15	of	of	ADP
asodahs-134	259	16	the	the	DET
asodahs-134	259	17	disease	disease	NOUN
asodahs-134	259	18	.	.	PUNCT
asodahs-134	260	1	1	1	X
asodahs-134	260	2	.	.	X
asodahs-134	260	3	free	free	ADJ
asodahs-134	260	4	hemoglobin	hemoglobin	NOUN
asodahs-134	260	5	scavenging	scavenging	NOUN
asodahs-134	260	6	of	of	ADP
asodahs-134	260	7	no	no	DET
asodahs-134	260	8	one	one	NUM
asodahs-134	260	9	of	of	ADP
asodahs-134	260	10	the	the	DET
asodahs-134	260	11	primary	primary	ADJ
asodahs-134	260	12	mechanisms	mechanism	NOUN
asodahs-134	260	13	of	of	ADP
asodahs-134	260	14	no	no	DET
asodahs-134	260	15	depletion	depletion	NOUN
asodahs-134	260	16	in	in	ADP
asodahs-134	260	17	scd	scd	PROPN
asodahs-134	260	18	is	be	AUX
asodahs-134	260	19	the	the	DET
asodahs-134	260	20	release	release	NOUN
asodahs-134	260	21	of	of	ADP
asodahs-134	260	22	free	free	ADJ
asodahs-134	260	23	hemoglobin	hemoglobin	NOUN
asodahs-134	260	24	into	into	ADP
asodahs-134	260	25	the	the	DET
asodahs-134	260	26	bloodstream	bloodstream	NOUN
asodahs-134	260	27	due	due	ADP
asodahs-134	260	28	to	to	ADP
asodahs-134	260	29	the	the	DET
asodahs-134	260	30	chronic	chronic	ADJ
asodahs-134	260	31	hemolysis	hemolysis	NOUN
asodahs-134	260	32	of	of	ADP
asodahs-134	260	33	sickled	sickled	ADJ
asodahs-134	260	34	red	red	ADJ
asodahs-134	260	35	blood	blood	NOUN
asodahs-134	260	36	cells	cell	NOUN
asodahs-134	260	37	.	.	PUNCT
asodahs-134	261	1	when	when	SCONJ
asodahs-134	261	2	red	red	ADJ
asodahs-134	261	3	blood	blood	NOUN
asodahs-134	261	4	cells	cell	NOUN
asodahs-134	261	5	become	become	VERB
asodahs-134	261	6	deformed	deformed	ADJ
asodahs-134	261	7	and	and	CCONJ
asodahs-134	261	8	brittle	brittle	ADJ
asodahs-134	261	9	,	,	PUNCT
asodahs-134	261	10	they	they	PRON
asodahs-134	261	11	rupture	rupture	VERB
asodahs-134	261	12	prematurely	prematurely	ADV
asodahs-134	261	13	,	,	PUNCT
asodahs-134	261	14	releasing	release	VERB
asodahs-134	261	15	hemoglobin	hemoglobin	NOUN
asodahs-134	261	16	into	into	ADP
asodahs-134	261	17	the	the	DET
asodahs-134	261	18	plasma	plasma	NOUN
asodahs-134	261	19	.	.	PUNCT
asodahs-134	262	1	this	this	DET
asodahs-134	262	2	free	free	ADJ
asodahs-134	262	3	hemoglobin	hemoglobin	NOUN
asodahs-134	262	4	binds	bind	VERB
asodahs-134	262	5	directly	directly	ADV
asodahs-134	262	6	to	to	ADP
asodahs-134	262	7	no	no	PRON
asodahs-134	262	8	,	,	PUNCT
asodahs-134	262	9	forming	form	VERB
asodahs-134	262	10	a	a	DET
asodahs-134	262	11	nitrosylated	nitrosylated	ADJ
asodahs-134	262	12	product	product	NOUN
asodahs-134	262	13	,	,	PUNCT
asodahs-134	262	14	which	which	PRON
asodahs-134	262	15	effectively	effectively	ADV
asodahs-134	262	16	inactivates	inactivate	VERB
asodahs-134	262	17	no	no	ADV
asodahs-134	262	18	and	and	CCONJ
asodahs-134	262	19	reduces	reduce	VERB
asodahs-134	262	20	its	its	PRON
asodahs-134	262	21	bioavailability	bioavailability	NOUN
asodahs-134	262	22	.	.	PUNCT
asodahs-134	263	1	the	the	DET
asodahs-134	263	2	scavenging	scavenging	NOUN
asodahs-134	263	3	of	of	ADP
asodahs-134	263	4	no	no	PRON
asodahs-134	263	5	by	by	ADP
asodahs-134	263	6	free	free	ADJ
asodahs-134	263	7	hemoglobin	hemoglobin	NOUN
asodahs-134	263	8	is	be	AUX
asodahs-134	263	9	particularly	particularly	ADV
asodahs-134	263	10	problematic	problematic	ADJ
asodahs-134	263	11	because	because	SCONJ
asodahs-134	263	12	it	it	PRON
asodahs-134	263	13	prevents	prevent	VERB
asodahs-134	263	14	no	no	ADV
asodahs-134	263	15	from	from	ADP
asodahs-134	263	16	performing	perform	VERB
asodahs-134	263	17	its	its	PRON
asodahs-134	263	18	normal	normal	ADJ
asodahs-134	263	19	vasodilatory	vasodilatory	NOUN
asodahs-134	263	20	function	function	NOUN
asodahs-134	263	21	,	,	PUNCT
asodahs-134	263	22	leading	lead	VERB
asodahs-134	263	23	to	to	ADP
asodahs-134	263	24	vasoconstriction	vasoconstriction	NOUN
asodahs-134	263	25	,	,	PUNCT
asodahs-134	263	26	increased	increase	VERB
asodahs-134	263	27	blood	blood	NOUN
asodahs-134	263	28	pressure	pressure	NOUN
asodahs-134	263	29	,	,	PUNCT
asodahs-134	263	30	and	and	CCONJ
asodahs-134	263	31	reduced	reduce	VERB
asodahs-134	263	32	tissue	tissue	NOUN
asodahs-134	263	33	oxygenation	oxygenation	NOUN
asodahs-134	263	34	.	.	PUNCT
asodahs-134	264	1	this	this	DET
asodahs-134	264	2	process	process	NOUN
asodahs-134	264	3	is	be	AUX
asodahs-134	264	4	thought	think	VERB
asodahs-134	264	5	to	to	PART
asodahs-134	264	6	contribute	contribute	VERB
asodahs-134	264	7	significantly	significantly	ADV
asodahs-134	264	8	to	to	ADP
asodahs-134	264	9	the	the	DET
asodahs-134	264	10	vascular	vascular	ADJ
asodahs-134	264	11	complications	complication	NOUN
asodahs-134	264	12	observed	observe	VERB
asodahs-134	264	13	in	in	ADP
asodahs-134	264	14	scd	scd	PROPN
asodahs-134	264	15	,	,	PUNCT
asodahs-134	264	16	such	such	ADJ
asodahs-134	264	17	as	as	ADP
asodahs-134	264	18	pulmonary	pulmonary	ADJ
asodahs-134	264	19	hypertension	hypertension	NOUN
asodahs-134	264	20	and	and	CCONJ
asodahs-134	264	21	stroke	stroke	NOUN
asodahs-134	264	22	17	17	NUM
asodahs-134	264	23	.	.	PUNCT
asodahs-134	265	1	2	2	X
asodahs-134	265	2	.	.	X
asodahs-134	265	3	oxidative	oxidative	ADJ
asodahs-134	265	4	stress	stress	NOUN
asodahs-134	265	5	and	and	CCONJ
asodahs-134	265	6	impaired	impair	VERB
asodahs-134	265	7	endothelial	endothelial	ADJ
asodahs-134	265	8	nitric	nitric	ADJ
asodahs-134	265	9	oxide	oxide	NOUN
asodahs-134	265	10	synthase	synthase	NOUN
asodahs-134	265	11	(	(	PUNCT
asodahs-134	265	12	enos	eno	NOUN
asodahs-134	265	13	)	)	PUNCT
asodahs-134	265	14	activity	activity	NOUN
asodahs-134	265	15	oxidative	oxidative	ADJ
asodahs-134	265	16	stress	stress	NOUN
asodahs-134	265	17	plays	play	VERB
asodahs-134	265	18	a	a	DET
asodahs-134	265	19	crucial	crucial	ADJ
asodahs-134	265	20	role	role	NOUN
asodahs-134	265	21	in	in	ADP
asodahs-134	265	22	the	the	DET
asodahs-134	265	23	depletion	depletion	NOUN
asodahs-134	265	24	of	of	ADP
asodahs-134	265	25	no	no	PRON
asodahs-134	265	26	in	in	ADP
asodahs-134	265	27	scd	scd	PROPN
asodahs-134	265	28	.	.	PUNCT
asodahs-134	266	1	the	the	DET
asodahs-134	266	2	chronic	chronic	ADJ
asodahs-134	266	3	hemolysis	hemolysis	NOUN
asodahs-134	266	4	of	of	ADP
asodahs-134	266	5	sickled	sickled	ADJ
asodahs-134	266	6	cells	cell	NOUN
asodahs-134	266	7	leads	lead	VERB
asodahs-134	266	8	to	to	ADP
asodahs-134	266	9	the	the	DET
asodahs-134	266	10	release	release	NOUN
asodahs-134	266	11	of	of	ADP
asodahs-134	266	12	heme	heme	NOUN
asodahs-134	266	13	,	,	PUNCT
asodahs-134	266	14	which	which	PRON
asodahs-134	266	15	induces	induce	VERB
asodahs-134	266	16	the	the	DET
asodahs-134	266	17	generation	generation	NOUN
asodahs-134	266	18	of	of	ADP
asodahs-134	266	19	reactive	reactive	ADJ
asodahs-134	266	20	oxygen	oxygen	NOUN
asodahs-134	266	21	species	specie	NOUN
asodahs-134	266	22	(	(	PUNCT
asodahs-134	266	23	ros	ros	PROPN
asodahs-134	266	24	)	)	PUNCT
asodahs-134	266	25	and	and	CCONJ
asodahs-134	266	26	reactive	reactive	ADJ
asodahs-134	266	27	nitrogen	nitrogen	NOUN
asodahs-134	266	28	species	specie	NOUN
asodahs-134	266	29	(	(	PUNCT
asodahs-134	266	30	rns	rn	NOUN
asodahs-134	266	31	)	)	PUNCT
asodahs-134	266	32	.	.	PUNCT
asodahs-134	267	1	these	these	DET
asodahs-134	267	2	highly	highly	ADV
asodahs-134	267	3	reactive	reactive	ADJ
asodahs-134	267	4	molecules	molecule	NOUN
asodahs-134	267	5	not	not	PART
asodahs-134	267	6	only	only	ADV
asodahs-134	267	7	damage	damage	VERB
asodahs-134	267	8	endothelial	endothelial	NOUN
asodahs-134	267	9	cells	cell	NOUN
asodahs-134	267	10	but	but	CCONJ
asodahs-134	267	11	also	also	ADV
asodahs-134	267	12	impair	impair	VERB
asodahs-134	267	13	the	the	DET
asodahs-134	267	14	function	function	NOUN
asodahs-134	267	15	of	of	ADP
asodahs-134	267	16	endothelial	endothelial	ADJ
asodahs-134	267	17	nitric	nitric	ADJ
asodahs-134	267	18	oxide	oxide	NOUN
asodahs-134	267	19	synthase	synthase	NOUN
asodahs-134	267	20	(	(	PUNCT
asodahs-134	267	21	enos	enos	PROPN
asodahs-134	267	22	)	)	PUNCT
asodahs-134	267	23	,	,	PUNCT
asodahs-134	267	24	the	the	DET
asodahs-134	267	25	enzyme	enzyme	NOUN
asodahs-134	267	26	emmanuel	emmanuel	PROPN
asodahs-134	267	27	ifeanyi	ifeanyi	PROPN
asodahs-134	267	28	obeagu	obeagu	PROPN
asodahs-134	267	29	asian	asian	PROPN
asodahs-134	267	30	journal	journal	PROPN
asodahs-134	267	31	of	of	ADP
asodahs-134	267	32	dental	dental	ADJ
asodahs-134	267	33	and	and	CCONJ
asodahs-134	267	34	health	health	NOUN
asodahs-134	267	35	sciences	science	NOUN
asodahs-134	267	36	.	.	PUNCT
asodahs-134	267	37	2025	2025	NUM
asodahs-134	267	38	;	;	PUNCT
asodahs-134	267	39	5(3):6	5(3):6	NUM
asodahs-134	267	40	-	-	SYM
asodahs-134	267	41	12	12	NUM
asodahs-134	268	1	[	[	NOUN
asodahs-134	268	2	8	8	NUM
asodahs-134	268	3	]	]	PUNCT
asodahs-134	268	4	ajdhs.com	ajdhs.com	X
asodahs-134	268	5	responsible	responsible	ADJ
asodahs-134	268	6	for	for	ADP
asodahs-134	268	7	the	the	DET
asodahs-134	268	8	production	production	NOUN
asodahs-134	268	9	of	of	ADP
asodahs-134	268	10	no	no	NOUN
asodahs-134	268	11	.	.	PUNCT
asodahs-134	269	1	ros	ros	PROPN
asodahs-134	269	2	can	can	AUX
asodahs-134	269	3	induce	induce	VERB
asodahs-134	269	4	the	the	DET
asodahs-134	269	5	uncoupling	uncoupling	NOUN
asodahs-134	269	6	of	of	ADP
asodahs-134	269	7	enos	eno	NOUN
asodahs-134	269	8	,	,	PUNCT
asodahs-134	269	9	which	which	PRON
asodahs-134	269	10	converts	convert	VERB
asodahs-134	269	11	it	it	PRON
asodahs-134	269	12	from	from	ADP
asodahs-134	269	13	a	a	DET
asodahs-134	269	14	noproducing	noproduce	VERB
asodahs-134	269	15	enzyme	enzyme	NOUN
asodahs-134	269	16	to	to	ADP
asodahs-134	269	17	a	a	DET
asodahs-134	269	18	superoxide	superoxide	NOUN
asodahs-134	269	19	-	-	PUNCT
asodahs-134	269	20	generating	generate	VERB
asodahs-134	269	21	enzyme	enzyme	NOUN
asodahs-134	269	22	.	.	PUNCT
asodahs-134	270	1	the	the	DET
asodahs-134	270	2	production	production	NOUN
asodahs-134	270	3	of	of	ADP
asodahs-134	270	4	superoxide	superoxide	NOUN
asodahs-134	270	5	(	(	PUNCT
asodahs-134	270	6	o2−	o2−	NOUN
asodahs-134	270	7	)	)	PUNCT
asodahs-134	270	8	further	far	ADV
asodahs-134	270	9	exacerbates	exacerbate	VERB
asodahs-134	270	10	oxidative	oxidative	ADJ
asodahs-134	270	11	stress	stress	NOUN
asodahs-134	270	12	and	and	CCONJ
asodahs-134	270	13	competes	compete	VERB
asodahs-134	270	14	with	with	ADP
asodahs-134	270	15	no	no	PRON
asodahs-134	270	16	,	,	PUNCT
asodahs-134	270	17	reducing	reduce	VERB
asodahs-134	270	18	its	its	PRON
asodahs-134	270	19	availability	availability	NOUN
asodahs-134	270	20	.	.	PUNCT
asodahs-134	271	1	this	this	DET
asodahs-134	271	2	impairment	impairment	NOUN
asodahs-134	271	3	in	in	ADP
asodahs-134	271	4	enos	enos	PROPN
asodahs-134	271	5	function	function	PROPN
asodahs-134	271	6	is	be	AUX
asodahs-134	271	7	a	a	DET
asodahs-134	271	8	critical	critical	ADJ
asodahs-134	271	9	contributor	contributor	NOUN
asodahs-134	271	10	to	to	ADP
asodahs-134	271	11	endothelial	endothelial	ADJ
asodahs-134	271	12	dysfunction	dysfunction	NOUN
asodahs-134	271	13	and	and	CCONJ
asodahs-134	271	14	the	the	DET
asodahs-134	271	15	inability	inability	NOUN
asodahs-134	271	16	of	of	ADP
asodahs-134	271	17	blood	blood	NOUN
asodahs-134	271	18	vessels	vessel	NOUN
asodahs-134	271	19	to	to	PART
asodahs-134	271	20	dilate	dilate	VERB
asodahs-134	271	21	properly	properly	ADV
asodahs-134	271	22	in	in	ADP
asodahs-134	271	23	response	response	NOUN
asodahs-134	271	24	to	to	ADP
asodahs-134	271	25	no	no	DET
asodahs-134	271	26	18	18	NUM
asodahs-134	271	27	.	.	PUNCT
asodahs-134	272	1	3	3	X
asodahs-134	272	2	.	.	X
asodahs-134	272	3	upregulation	upregulation	NOUN
asodahs-134	272	4	of	of	ADP
asodahs-134	272	5	arginase	arginase	NOUN
asodahs-134	272	6	and	and	CCONJ
asodahs-134	272	7	substrate	substrate	NOUN
asodahs-134	272	8	competition	competition	NOUN
asodahs-134	272	9	another	another	DET
asodahs-134	272	10	key	key	ADJ
asodahs-134	272	11	mechanism	mechanism	NOUN
asodahs-134	272	12	of	of	ADP
asodahs-134	272	13	no	no	DET
asodahs-134	272	14	depletion	depletion	NOUN
asodahs-134	272	15	in	in	ADP
asodahs-134	272	16	scd	scd	PROPN
asodahs-134	272	17	is	be	AUX
asodahs-134	272	18	the	the	DET
asodahs-134	272	19	increased	increase	VERB
asodahs-134	272	20	activity	activity	NOUN
asodahs-134	272	21	of	of	ADP
asodahs-134	272	22	arginase	arginase	NOUN
asodahs-134	272	23	,	,	PUNCT
asodahs-134	272	24	an	an	DET
asodahs-134	272	25	enzyme	enzyme	NOUN
asodahs-134	272	26	that	that	PRON
asodahs-134	272	27	metabolizes	metabolize	VERB
asodahs-134	272	28	l	l	NOUN
asodahs-134	272	29	-	-	NOUN
asodahs-134	272	30	arginine	arginine	NOUN
asodahs-134	272	31	,	,	PUNCT
asodahs-134	272	32	the	the	DET
asodahs-134	272	33	substrate	substrate	NOUN
asodahs-134	272	34	required	require	VERB
asodahs-134	272	35	for	for	ADP
asodahs-134	272	36	no	no	DET
asodahs-134	272	37	synthesis	synthesis	NOUN
asodahs-134	272	38	by	by	ADP
asodahs-134	272	39	enos	eno	NOUN
asodahs-134	272	40	.	.	PUNCT
asodahs-134	273	1	in	in	ADP
asodahs-134	273	2	scd	scd	PROPN
asodahs-134	273	3	,	,	PUNCT
asodahs-134	273	4	arginase	arginase	PROPN
asodahs-134	273	5	levels	level	NOUN
asodahs-134	273	6	are	be	AUX
asodahs-134	273	7	elevated	elevate	VERB
asodahs-134	273	8	due	due	ADP
asodahs-134	273	9	to	to	ADP
asodahs-134	273	10	the	the	DET
asodahs-134	273	11	stress	stress	NOUN
asodahs-134	273	12	and	and	CCONJ
asodahs-134	273	13	inflammation	inflammation	NOUN
asodahs-134	273	14	caused	cause	VERB
asodahs-134	273	15	by	by	ADP
asodahs-134	273	16	hemolysis	hemolysis	NOUN
asodahs-134	273	17	.	.	PUNCT
asodahs-134	274	1	arginase	arginase	PROPN
asodahs-134	274	2	hydrolyzes	hydrolyzes	PROPN
asodahs-134	274	3	l	l	NOUN
asodahs-134	274	4	-	-	NOUN
asodahs-134	274	5	arginine	arginine	NOUN
asodahs-134	274	6	into	into	ADP
asodahs-134	274	7	ornithine	ornithine	NOUN
asodahs-134	274	8	and	and	CCONJ
asodahs-134	274	9	urea	urea	NOUN
asodahs-134	274	10	,	,	PUNCT
asodahs-134	274	11	thereby	thereby	ADV
asodahs-134	274	12	reducing	reduce	VERB
asodahs-134	274	13	the	the	DET
asodahs-134	274	14	amount	amount	NOUN
asodahs-134	274	15	of	of	ADP
asodahs-134	274	16	l	l	NOUN
asodahs-134	274	17	-	-	NOUN
asodahs-134	274	18	arginine	arginine	NOUN
asodahs-134	274	19	available	available	ADJ
asodahs-134	274	20	for	for	ADP
asodahs-134	274	21	enos	eno	NOUN
asodahs-134	274	22	to	to	PART
asodahs-134	274	23	produce	produce	VERB
asodahs-134	274	24	no	no	NOUN
asodahs-134	274	25	.	.	PUNCT
asodahs-134	275	1	this	this	DET
asodahs-134	275	2	competition	competition	NOUN
asodahs-134	275	3	for	for	ADP
asodahs-134	275	4	l	l	NOUN
asodahs-134	275	5	-	-	NOUN
asodahs-134	275	6	arginine	arginine	NOUN
asodahs-134	275	7	between	between	ADP
asodahs-134	275	8	enos	eno	NOUN
asodahs-134	275	9	and	and	CCONJ
asodahs-134	275	10	arginase	arginase	NOUN
asodahs-134	275	11	is	be	AUX
asodahs-134	275	12	a	a	DET
asodahs-134	275	13	critical	critical	ADJ
asodahs-134	275	14	factor	factor	NOUN
asodahs-134	275	15	in	in	ADP
asodahs-134	275	16	the	the	DET
asodahs-134	275	17	depletion	depletion	NOUN
asodahs-134	275	18	of	of	ADP
asodahs-134	275	19	no	no	NOUN
asodahs-134	275	20	.	.	PUNCT
asodahs-134	276	1	as	as	SCONJ
asodahs-134	276	2	arginase	arginase	NOUN
asodahs-134	276	3	activity	activity	NOUN
asodahs-134	276	4	increases	increase	NOUN
asodahs-134	276	5	,	,	PUNCT
asodahs-134	276	6	the	the	DET
asodahs-134	276	7	substrate	substrate	NOUN
asodahs-134	276	8	for	for	ADP
asodahs-134	276	9	no	no	DET
asodahs-134	276	10	production	production	NOUN
asodahs-134	276	11	becomes	become	VERB
asodahs-134	276	12	limited	limited	ADJ
asodahs-134	276	13	,	,	PUNCT
asodahs-134	276	14	exacerbating	exacerbate	VERB
asodahs-134	276	15	the	the	DET
asodahs-134	276	16	deficit	deficit	NOUN
asodahs-134	276	17	of	of	ADP
asodahs-134	276	18	no	no	PRON
asodahs-134	276	19	in	in	ADP
asodahs-134	276	20	the	the	DET
asodahs-134	276	21	circulation	circulation	NOUN
asodahs-134	276	22	and	and	CCONJ
asodahs-134	276	23	contributing	contribute	VERB
asodahs-134	276	24	to	to	ADP
asodahs-134	276	25	the	the	DET
asodahs-134	276	26	persistence	persistence	NOUN
asodahs-134	276	27	of	of	ADP
asodahs-134	276	28	vascular	vascular	ADJ
asodahs-134	276	29	dysfunction	dysfunction	NOUN
asodahs-134	276	30	in	in	ADP
asodahs-134	276	31	scd	scd	PROPN
asodahs-134	276	32	19	19	NUM
asodahs-134	276	33	.	.	NOUN
asodahs-134	276	34	4	4	NUM
asodahs-134	276	35	.	.	X
asodahs-134	276	36	hemolysis	hemolysis	NOUN
asodahs-134	276	37	-	-	PUNCT
asodahs-134	276	38	induced	induce	VERB
asodahs-134	276	39	inflammation	inflammation	NOUN
asodahs-134	276	40	and	and	CCONJ
asodahs-134	276	41	immune	immune	ADJ
asodahs-134	276	42	activation	activation	NOUN
asodahs-134	276	43	the	the	DET
asodahs-134	276	44	ongoing	ongoing	ADJ
asodahs-134	276	45	hemolysis	hemolysis	NOUN
asodahs-134	276	46	in	in	ADP
asodahs-134	276	47	scd	scd	PROPN
asodahs-134	276	48	also	also	ADV
asodahs-134	276	49	triggers	trigger	VERB
asodahs-134	276	50	a	a	DET
asodahs-134	276	51	cascade	cascade	NOUN
asodahs-134	276	52	of	of	ADP
asodahs-134	276	53	inflammatory	inflammatory	ADJ
asodahs-134	276	54	responses	response	NOUN
asodahs-134	276	55	that	that	PRON
asodahs-134	276	56	further	far	ADV
asodahs-134	276	57	contribute	contribute	VERB
asodahs-134	276	58	to	to	ADP
asodahs-134	276	59	no	no	DET
asodahs-134	276	60	depletion	depletion	NOUN
asodahs-134	276	61	.	.	PUNCT
asodahs-134	277	1	the	the	DET
asodahs-134	277	2	release	release	NOUN
asodahs-134	277	3	of	of	ADP
asodahs-134	277	4	cell	cell	NOUN
asodahs-134	277	5	-	-	PUNCT
asodahs-134	277	6	free	free	ADJ
asodahs-134	277	7	hemoglobin	hemoglobin	NOUN
asodahs-134	277	8	and	and	CCONJ
asodahs-134	277	9	other	other	ADJ
asodahs-134	277	10	hemolytic	hemolytic	ADJ
asodahs-134	277	11	products	product	NOUN
asodahs-134	277	12	activates	activate	VERB
asodahs-134	277	13	the	the	DET
asodahs-134	277	14	innate	innate	ADJ
asodahs-134	277	15	immune	immune	ADJ
asodahs-134	277	16	system	system	NOUN
asodahs-134	277	17	,	,	PUNCT
asodahs-134	277	18	leading	lead	VERB
asodahs-134	277	19	to	to	ADP
asodahs-134	277	20	the	the	DET
asodahs-134	277	21	production	production	NOUN
asodahs-134	277	22	of	of	ADP
asodahs-134	277	23	pro	pro	ADJ
asodahs-134	277	24	-	-	ADJ
asodahs-134	277	25	inflammatory	inflammatory	ADJ
asodahs-134	277	26	cytokines	cytokine	NOUN
asodahs-134	277	27	and	and	CCONJ
asodahs-134	277	28	the	the	DET
asodahs-134	277	29	recruitment	recruitment	NOUN
asodahs-134	277	30	of	of	ADP
asodahs-134	277	31	leukocytes	leukocyte	NOUN
asodahs-134	277	32	to	to	ADP
asodahs-134	277	33	the	the	DET
asodahs-134	277	34	site	site	NOUN
asodahs-134	277	35	of	of	ADP
asodahs-134	277	36	injury	injury	NOUN
asodahs-134	277	37	.	.	PUNCT
asodahs-134	278	1	inflammation	inflammation	NOUN
asodahs-134	278	2	increases	increase	VERB
asodahs-134	278	3	the	the	DET
asodahs-134	278	4	production	production	NOUN
asodahs-134	278	5	of	of	ADP
asodahs-134	278	6	ros	ros	PROPN
asodahs-134	278	7	and	and	CCONJ
asodahs-134	278	8	rns	rns	PROPN
asodahs-134	278	9	,	,	PUNCT
asodahs-134	278	10	which	which	PRON
asodahs-134	278	11	not	not	PART
asodahs-134	278	12	only	only	ADV
asodahs-134	278	13	damage	damage	VERB
asodahs-134	278	14	endothelial	endothelial	NOUN
asodahs-134	278	15	cells	cell	NOUN
asodahs-134	278	16	but	but	CCONJ
asodahs-134	278	17	also	also	ADV
asodahs-134	278	18	reduce	reduce	VERB
asodahs-134	278	19	the	the	DET
asodahs-134	278	20	bioavailability	bioavailability	NOUN
asodahs-134	278	21	of	of	ADP
asodahs-134	278	22	no	no	NOUN
asodahs-134	278	23	.	.	PUNCT
asodahs-134	279	1	additionally	additionally	ADV
asodahs-134	279	2	,	,	PUNCT
asodahs-134	279	3	pro	pro	ADJ
asodahs-134	279	4	-	-	ADJ
asodahs-134	279	5	inflammatory	inflammatory	ADJ
asodahs-134	279	6	cytokines	cytokine	NOUN
asodahs-134	279	7	such	such	ADJ
asodahs-134	279	8	as	as	ADP
asodahs-134	279	9	tumor	tumor	NOUN
asodahs-134	279	10	necrosis	necrosis	NOUN
asodahs-134	279	11	factor	factor	NOUN
asodahs-134	279	12	-	-	PUNCT
asodahs-134	279	13	alpha	alpha	NOUN
asodahs-134	279	14	(	(	PUNCT
asodahs-134	279	15	tnf	tnf	PROPN
asodahs-134	279	16	-	-	PUNCT
asodahs-134	279	17	α	α	NOUN
asodahs-134	279	18	)	)	PUNCT
asodahs-134	279	19	and	and	CCONJ
asodahs-134	279	20	interleukin-6	interleukin-6	NUM
asodahs-134	279	21	(	(	PUNCT
asodahs-134	279	22	il-6	il-6	NUM
asodahs-134	279	23	)	)	PUNCT
asodahs-134	279	24	can	can	AUX
asodahs-134	279	25	downregulate	downregulate	VERB
asodahs-134	279	26	enos	enos	PROPN
asodahs-134	279	27	expression	expression	NOUN
asodahs-134	279	28	,	,	PUNCT
asodahs-134	279	29	further	far	ADV
asodahs-134	279	30	impairing	impair	VERB
asodahs-134	279	31	no	no	DET
asodahs-134	279	32	synthesis	synthesis	NOUN
asodahs-134	279	33	and	and	CCONJ
asodahs-134	279	34	exacerbating	exacerbate	VERB
asodahs-134	279	35	endothelial	endothelial	ADJ
asodahs-134	279	36	dysfunction	dysfunction	NOUN
asodahs-134	279	37	20	20	NUM
asodahs-134	279	38	.	.	PUNCT
asodahs-134	280	1	5	5	NUM
asodahs-134	280	2	.	.	PUNCT
asodahs-134	280	3	impaired	impair	VERB
asodahs-134	280	4	nitric	nitric	ADJ
asodahs-134	280	5	oxide	oxide	NOUN
asodahs-134	280	6	synthase	synthase	NOUN
asodahs-134	280	7	coupling	coupling	NOUN
asodahs-134	280	8	and	and	CCONJ
asodahs-134	280	9	enos	eno	VERB
asodahs-134	280	10	dysfunction	dysfunction	NOUN
asodahs-134	280	11	the	the	DET
asodahs-134	280	12	activity	activity	NOUN
asodahs-134	280	13	of	of	ADP
asodahs-134	280	14	enos	enos	PROPN
asodahs-134	280	15	in	in	ADP
asodahs-134	280	16	scd	scd	PROPN
asodahs-134	280	17	is	be	AUX
asodahs-134	280	18	further	far	ADV
asodahs-134	280	19	compromised	compromise	VERB
asodahs-134	280	20	by	by	ADP
asodahs-134	280	21	factors	factor	NOUN
asodahs-134	280	22	such	such	ADJ
asodahs-134	280	23	as	as	ADP
asodahs-134	280	24	oxidative	oxidative	ADJ
asodahs-134	280	25	stress	stress	NOUN
asodahs-134	280	26	and	and	CCONJ
asodahs-134	280	27	altered	alter	VERB
asodahs-134	280	28	redox	redox	ADJ
asodahs-134	280	29	status	status	NOUN
asodahs-134	280	30	.	.	PUNCT
asodahs-134	281	1	under	under	ADP
asodahs-134	281	2	normal	normal	ADJ
asodahs-134	281	3	conditions	condition	NOUN
asodahs-134	281	4	,	,	PUNCT
asodahs-134	281	5	enos	enos	PROPN
asodahs-134	281	6	functions	function	NOUN
asodahs-134	281	7	as	as	ADP
asodahs-134	281	8	a	a	DET
asodahs-134	281	9	dimer	dimer	NOUN
asodahs-134	281	10	,	,	PUNCT
asodahs-134	281	11	efficiently	efficiently	ADV
asodahs-134	281	12	converting	convert	VERB
asodahs-134	281	13	l	l	NOUN
asodahs-134	281	14	-	-	NOUN
asodahs-134	281	15	arginine	arginine	NOUN
asodahs-134	281	16	into	into	ADP
asodahs-134	281	17	no	no	NOUN
asodahs-134	281	18	.	.	PUNCT
asodahs-134	282	1	however	however	ADV
asodahs-134	282	2	,	,	PUNCT
asodahs-134	282	3	in	in	ADP
asodahs-134	282	4	the	the	DET
asodahs-134	282	5	presence	presence	NOUN
asodahs-134	282	6	of	of	ADP
asodahs-134	282	7	excessive	excessive	ADJ
asodahs-134	282	8	ros	ro	NOUN
asodahs-134	282	9	and	and	CCONJ
asodahs-134	282	10	oxidative	oxidative	ADJ
asodahs-134	282	11	stress	stress	NOUN
asodahs-134	282	12	,	,	PUNCT
asodahs-134	282	13	enos	enos	PROPN
asodahs-134	282	14	can	can	AUX
asodahs-134	282	15	become	become	VERB
asodahs-134	282	16	uncoupled	uncoupled	ADJ
asodahs-134	282	17	,	,	PUNCT
asodahs-134	282	18	meaning	mean	VERB
asodahs-134	282	19	that	that	SCONJ
asodahs-134	282	20	instead	instead	ADV
asodahs-134	282	21	of	of	ADP
asodahs-134	282	22	producing	produce	VERB
asodahs-134	282	23	no	no	INTJ
asodahs-134	282	24	,	,	PUNCT
asodahs-134	282	25	it	it	PRON
asodahs-134	282	26	generates	generate	VERB
asodahs-134	282	27	superoxide	superoxide	NOUN
asodahs-134	282	28	radicals	radical	NOUN
asodahs-134	282	29	.	.	PUNCT
asodahs-134	283	1	this	this	DET
asodahs-134	283	2	uncoupling	uncoupling	NOUN
asodahs-134	283	3	of	of	ADP
asodahs-134	283	4	enos	eno	NOUN
asodahs-134	283	5	not	not	PART
asodahs-134	283	6	only	only	ADV
asodahs-134	283	7	contributes	contribute	VERB
asodahs-134	283	8	to	to	ADP
asodahs-134	283	9	a	a	DET
asodahs-134	283	10	decrease	decrease	NOUN
asodahs-134	283	11	in	in	ADP
asodahs-134	283	12	no	no	DET
asodahs-134	283	13	bioavailability	bioavailability	NOUN
asodahs-134	283	14	but	but	CCONJ
asodahs-134	283	15	also	also	ADV
asodahs-134	283	16	increases	increase	VERB
asodahs-134	283	17	the	the	DET
asodahs-134	283	18	burden	burden	NOUN
asodahs-134	283	19	of	of	ADP
asodahs-134	283	20	oxidative	oxidative	ADJ
asodahs-134	283	21	stress	stress	NOUN
asodahs-134	283	22	,	,	PUNCT
asodahs-134	283	23	further	far	ADV
asodahs-134	283	24	damaging	damage	VERB
asodahs-134	283	25	endothelial	endothelial	ADJ
asodahs-134	283	26	cells	cell	NOUN
asodahs-134	283	27	and	and	CCONJ
asodahs-134	283	28	exacerbating	exacerbate	VERB
asodahs-134	283	29	vascular	vascular	ADJ
asodahs-134	283	30	dysfunction	dysfunction	NOUN
asodahs-134	283	31	.	.	PUNCT
asodahs-134	284	1	this	this	DET
asodahs-134	284	2	dysfunctional	dysfunctional	ADJ
asodahs-134	284	3	form	form	NOUN
asodahs-134	284	4	of	of	ADP
asodahs-134	284	5	enos	enos	PROPN
asodahs-134	284	6	accelerates	accelerate	VERB
asodahs-134	284	7	the	the	DET
asodahs-134	284	8	pathological	pathological	ADJ
asodahs-134	284	9	cycle	cycle	NOUN
asodahs-134	284	10	of	of	ADP
asodahs-134	284	11	vascular	vascular	ADJ
asodahs-134	284	12	injury	injury	NOUN
asodahs-134	284	13	in	in	ADP
asodahs-134	284	14	scd	scd	PROPN
asodahs-134	284	15	21	21	NUM
asodahs-134	284	16	.	.	NOUN
asodahs-134	285	1	6	6	NUM
asodahs-134	285	2	.	.	X
asodahs-134	285	3	implications	implication	NOUN
asodahs-134	285	4	for	for	ADP
asodahs-134	285	5	vascular	vascular	ADJ
asodahs-134	285	6	dysfunction	dysfunction	NOUN
asodahs-134	285	7	and	and	CCONJ
asodahs-134	285	8	clinical	clinical	ADJ
asodahs-134	285	9	outcomes	outcome	NOUN
asodahs-134	285	10	the	the	DET
asodahs-134	285	11	depletion	depletion	NOUN
asodahs-134	285	12	of	of	ADP
asodahs-134	285	13	no	no	PRON
asodahs-134	285	14	in	in	ADP
asodahs-134	285	15	scd	scd	PROPN
asodahs-134	285	16	has	have	VERB
asodahs-134	285	17	significant	significant	ADJ
asodahs-134	285	18	implications	implication	NOUN
asodahs-134	285	19	for	for	ADP
asodahs-134	285	20	vascular	vascular	ADJ
asodahs-134	285	21	function	function	NOUN
asodahs-134	285	22	and	and	CCONJ
asodahs-134	285	23	the	the	DET
asodahs-134	285	24	progression	progression	NOUN
asodahs-134	285	25	of	of	ADP
asodahs-134	285	26	disease	disease	NOUN
asodahs-134	285	27	complications	complication	NOUN
asodahs-134	285	28	.	.	PUNCT
asodahs-134	286	1	the	the	DET
asodahs-134	286	2	reduced	reduce	VERB
asodahs-134	286	3	no	no	DET
asodahs-134	286	4	bioavailability	bioavailability	NOUN
asodahs-134	286	5	leads	lead	VERB
asodahs-134	286	6	to	to	ADP
asodahs-134	286	7	endothelial	endothelial	ADJ
asodahs-134	286	8	dysfunction	dysfunction	NOUN
asodahs-134	286	9	,	,	PUNCT
asodahs-134	286	10	characterized	characterize	VERB
asodahs-134	286	11	by	by	ADP
asodahs-134	286	12	impaired	impaired	ADJ
asodahs-134	286	13	vasodilation	vasodilation	NOUN
asodahs-134	286	14	,	,	PUNCT
asodahs-134	286	15	increased	increase	VERB
asodahs-134	286	16	platelet	platelet	NOUN
asodahs-134	286	17	aggregation	aggregation	NOUN
asodahs-134	286	18	,	,	PUNCT
asodahs-134	286	19	and	and	CCONJ
asodahs-134	286	20	enhanced	enhance	VERB
asodahs-134	286	21	leukocyte	leukocyte	NOUN
asodahs-134	286	22	adhesion	adhesion	NOUN
asodahs-134	286	23	to	to	ADP
asodahs-134	286	24	the	the	DET
asodahs-134	286	25	endothelium	endothelium	NOUN
asodahs-134	286	26	.	.	PUNCT
asodahs-134	287	1	these	these	DET
asodahs-134	287	2	changes	change	NOUN
asodahs-134	287	3	contribute	contribute	VERB
asodahs-134	287	4	to	to	ADP
asodahs-134	287	5	the	the	DET
asodahs-134	287	6	formation	formation	NOUN
asodahs-134	287	7	of	of	ADP
asodahs-134	287	8	microvascular	microvascular	ADJ
asodahs-134	287	9	occlusions	occlusion	NOUN
asodahs-134	287	10	and	and	CCONJ
asodahs-134	287	11	increase	increase	VERB
asodahs-134	287	12	the	the	DET
asodahs-134	287	13	risk	risk	NOUN
asodahs-134	287	14	of	of	ADP
asodahs-134	287	15	thromboembolic	thromboembolic	ADJ
asodahs-134	287	16	events	event	NOUN
asodahs-134	287	17	,	,	PUNCT
asodahs-134	287	18	which	which	PRON
asodahs-134	287	19	are	be	AUX
asodahs-134	287	20	common	common	ADJ
asodahs-134	287	21	in	in	ADP
asodahs-134	287	22	scd	scd	PROPN
asodahs-134	287	23	.	.	PUNCT
asodahs-134	288	1	furthermore	furthermore	ADV
asodahs-134	288	2	,	,	PUNCT
asodahs-134	288	3	impaired	impaired	ADJ
asodahs-134	288	4	no	no	DET
asodahs-134	288	5	signaling	signal	VERB
asodahs-134	288	6	is	be	AUX
asodahs-134	288	7	associated	associate	VERB
asodahs-134	288	8	with	with	ADP
asodahs-134	288	9	the	the	DET
asodahs-134	288	10	development	development	NOUN
asodahs-134	288	11	of	of	ADP
asodahs-134	288	12	pulmonary	pulmonary	ADJ
asodahs-134	288	13	hypertension	hypertension	NOUN
asodahs-134	288	14	,	,	PUNCT
asodahs-134	288	15	a	a	DET
asodahs-134	288	16	leading	lead	VERB
asodahs-134	288	17	cause	cause	NOUN
asodahs-134	288	18	of	of	ADP
asodahs-134	288	19	morbidity	morbidity	NOUN
asodahs-134	288	20	and	and	CCONJ
asodahs-134	288	21	mortality	mortality	NOUN
asodahs-134	288	22	in	in	ADP
asodahs-134	288	23	scd	scd	NOUN
asodahs-134	288	24	patients	patient	NOUN
asodahs-134	288	25	.	.	PUNCT
asodahs-134	289	1	by	by	ADP
asodahs-134	289	2	promoting	promote	VERB
asodahs-134	289	3	vasoconstriction	vasoconstriction	NOUN
asodahs-134	289	4	,	,	PUNCT
asodahs-134	289	5	oxidative	oxidative	ADJ
asodahs-134	289	6	stress	stress	NOUN
asodahs-134	289	7	,	,	PUNCT
asodahs-134	289	8	and	and	CCONJ
asodahs-134	289	9	thrombotic	thrombotic	ADJ
asodahs-134	289	10	events	event	NOUN
asodahs-134	289	11	,	,	PUNCT
asodahs-134	289	12	no	no	DET
asodahs-134	289	13	depletion	depletion	NOUN
asodahs-134	289	14	exacerbates	exacerbate	VERB
asodahs-134	289	15	the	the	DET
asodahs-134	289	16	severity	severity	NOUN
asodahs-134	289	17	of	of	ADP
asodahs-134	289	18	acute	acute	ADJ
asodahs-134	289	19	vaso	vaso	NOUN
asodahs-134	289	20	-	-	PUNCT
asodahs-134	289	21	occlusive	occlusive	ADJ
asodahs-134	289	22	crises	crisis	NOUN
asodahs-134	289	23	and	and	CCONJ
asodahs-134	289	24	contributes	contribute	VERB
asodahs-134	289	25	to	to	ADP
asodahs-134	289	26	long	long	ADJ
asodahs-134	289	27	-	-	PUNCT
asodahs-134	289	28	term	term	NOUN
asodahs-134	289	29	vascular	vascular	ADJ
asodahs-134	289	30	complications	complication	NOUN
asodahs-134	289	31	,	,	PUNCT
asodahs-134	289	32	such	such	ADJ
asodahs-134	289	33	as	as	ADP
asodahs-134	289	34	stroke	stroke	NOUN
asodahs-134	289	35	,	,	PUNCT
asodahs-134	289	36	organ	organ	NOUN
asodahs-134	289	37	damage	damage	NOUN
asodahs-134	289	38	,	,	PUNCT
asodahs-134	289	39	and	and	CCONJ
asodahs-134	289	40	chronic	chronic	ADJ
asodahs-134	289	41	kidney	kidney	NOUN
asodahs-134	289	42	disease	disease	NOUN
asodahs-134	289	43	22	22	NUM
asodahs-134	289	44	.	.	PUNCT
asodahs-134	290	1	vascular	vascular	ADJ
asodahs-134	290	2	consequences	consequence	NOUN
asodahs-134	290	3	of	of	ADP
asodahs-134	290	4	nitric	nitric	ADJ
asodahs-134	290	5	oxide	oxide	NOUN
asodahs-134	290	6	deficiency	deficiency	NOUN
asodahs-134	290	7	in	in	ADP
asodahs-134	290	8	sickle	sickle	NOUN
asodahs-134	290	9	cell	cell	NOUN
asodahs-134	290	10	disease	disease	NOUN
asodahs-134	290	11	(	(	PUNCT
asodahs-134	290	12	scd	scd	NOUN
asodahs-134	290	13	)	)	PUNCT
asodahs-134	290	14	nitric	nitric	ADJ
asodahs-134	290	15	oxide	oxide	NOUN
asodahs-134	290	16	(	(	PUNCT
asodahs-134	290	17	no	no	NOUN
asodahs-134	290	18	)	)	PUNCT
asodahs-134	290	19	plays	play	VERB
asodahs-134	290	20	an	an	DET
asodahs-134	290	21	essential	essential	ADJ
asodahs-134	290	22	role	role	NOUN
asodahs-134	290	23	in	in	ADP
asodahs-134	290	24	maintaining	maintain	VERB
asodahs-134	290	25	vascular	vascular	ADJ
asodahs-134	290	26	health	health	NOUN
asodahs-134	290	27	by	by	ADP
asodahs-134	290	28	regulating	regulate	VERB
asodahs-134	290	29	blood	blood	NOUN
asodahs-134	290	30	vessel	vessel	NOUN
asodahs-134	290	31	tone	tone	NOUN
asodahs-134	290	32	,	,	PUNCT
asodahs-134	290	33	inhibiting	inhibit	VERB
asodahs-134	290	34	platelet	platelet	NOUN
asodahs-134	290	35	aggregation	aggregation	NOUN
asodahs-134	290	36	,	,	PUNCT
asodahs-134	290	37	reducing	reduce	VERB
asodahs-134	290	38	inflammation	inflammation	NOUN
asodahs-134	290	39	,	,	PUNCT
asodahs-134	290	40	and	and	CCONJ
asodahs-134	290	41	preventing	prevent	VERB
asodahs-134	290	42	vascular	vascular	ADJ
asodahs-134	290	43	smooth	smooth	ADJ
asodahs-134	290	44	muscle	muscle	NOUN
asodahs-134	290	45	cell	cell	NOUN
asodahs-134	290	46	proliferation	proliferation	NOUN
asodahs-134	290	47	.	.	PUNCT
asodahs-134	291	1	in	in	ADP
asodahs-134	291	2	sickle	sickle	NOUN
asodahs-134	291	3	cell	cell	NOUN
asodahs-134	291	4	disease	disease	NOUN
asodahs-134	291	5	(	(	PUNCT
asodahs-134	291	6	scd	scd	NOUN
asodahs-134	291	7	)	)	PUNCT
asodahs-134	291	8	,	,	PUNCT
asodahs-134	291	9	a	a	DET
asodahs-134	291	10	deficiency	deficiency	NOUN
asodahs-134	291	11	in	in	ADP
asodahs-134	291	12	no	no	DET
asodahs-134	291	13	bioavailability	bioavailability	NOUN
asodahs-134	291	14	has	have	VERB
asodahs-134	291	15	profound	profound	ADJ
asodahs-134	291	16	consequences	consequence	NOUN
asodahs-134	291	17	for	for	ADP
asodahs-134	291	18	vascular	vascular	ADJ
asodahs-134	291	19	function	function	NOUN
asodahs-134	291	20	,	,	PUNCT
asodahs-134	291	21	leading	lead	VERB
asodahs-134	291	22	to	to	ADP
asodahs-134	291	23	a	a	DET
asodahs-134	291	24	variety	variety	NOUN
asodahs-134	291	25	of	of	ADP
asodahs-134	291	26	complications	complication	NOUN
asodahs-134	291	27	that	that	PRON
asodahs-134	291	28	significantly	significantly	ADV
asodahs-134	291	29	impact	impact	VERB
asodahs-134	291	30	patient	patient	ADJ
asodahs-134	291	31	outcomes	outcome	NOUN
asodahs-134	291	32	.	.	PUNCT
asodahs-134	292	1	these	these	DET
asodahs-134	292	2	vascular	vascular	ADJ
asodahs-134	292	3	consequences	consequence	NOUN
asodahs-134	292	4	are	be	AUX
asodahs-134	292	5	primarily	primarily	ADV
asodahs-134	292	6	driven	drive	VERB
asodahs-134	292	7	by	by	ADP
asodahs-134	292	8	the	the	DET
asodahs-134	292	9	loss	loss	NOUN
asodahs-134	292	10	of	of	ADP
asodahs-134	292	11	no	no	PRON
asodahs-134	292	12	's	's	PART
asodahs-134	292	13	vasodilatory	vasodilatory	NOUN
asodahs-134	292	14	effects	effect	NOUN
asodahs-134	292	15	,	,	PUNCT
asodahs-134	292	16	the	the	DET
asodahs-134	292	17	promotion	promotion	NOUN
asodahs-134	292	18	of	of	ADP
asodahs-134	292	19	vasoconstriction	vasoconstriction	NOUN
asodahs-134	292	20	,	,	PUNCT
asodahs-134	292	21	and	and	CCONJ
asodahs-134	292	22	the	the	DET
asodahs-134	292	23	dysregulation	dysregulation	NOUN
asodahs-134	292	24	of	of	ADP
asodahs-134	292	25	endothelial	endothelial	ADJ
asodahs-134	292	26	function	function	NOUN
asodahs-134	292	27	,	,	PUNCT
asodahs-134	292	28	which	which	PRON
asodahs-134	292	29	together	together	ADV
asodahs-134	292	30	contribute	contribute	VERB
asodahs-134	292	31	to	to	ADP
asodahs-134	292	32	the	the	DET
asodahs-134	292	33	pathophysiology	pathophysiology	NOUN
asodahs-134	292	34	of	of	ADP
asodahs-134	292	35	scd	scd	PROPN
asodahs-134	292	36	.	.	PROPN
asodahs-134	293	1	1	1	NUM
asodahs-134	293	2	.	.	X
asodahs-134	293	3	endothelial	endothelial	ADJ
asodahs-134	293	4	dysfunction	dysfunction	NOUN
asodahs-134	293	5	endothelial	endothelial	NOUN
asodahs-134	293	6	cells	cell	NOUN
asodahs-134	293	7	are	be	AUX
asodahs-134	293	8	critical	critical	ADJ
asodahs-134	293	9	in	in	ADP
asodahs-134	293	10	regulating	regulate	VERB
asodahs-134	293	11	vascular	vascular	ADJ
asodahs-134	293	12	tone	tone	NOUN
asodahs-134	293	13	and	and	CCONJ
asodahs-134	293	14	maintaining	maintain	VERB
asodahs-134	293	15	the	the	DET
asodahs-134	293	16	integrity	integrity	NOUN
asodahs-134	293	17	of	of	ADP
asodahs-134	293	18	the	the	DET
asodahs-134	293	19	vascular	vascular	ADJ
asodahs-134	293	20	wall	wall	NOUN
asodahs-134	293	21	.	.	PUNCT
asodahs-134	294	1	in	in	ADP
asodahs-134	294	2	scd	scd	PROPN
asodahs-134	294	3	,	,	PUNCT
asodahs-134	294	4	the	the	DET
asodahs-134	294	5	reduced	reduced	ADJ
asodahs-134	294	6	bioavailability	bioavailability	NOUN
asodahs-134	294	7	of	of	ADP
asodahs-134	294	8	no	no	DET
asodahs-134	294	9	leads	lead	NOUN
asodahs-134	294	10	to	to	ADP
asodahs-134	294	11	endothelial	endothelial	ADJ
asodahs-134	294	12	dysfunction	dysfunction	NOUN
asodahs-134	294	13	,	,	PUNCT
asodahs-134	294	14	a	a	DET
asodahs-134	294	15	state	state	NOUN
asodahs-134	294	16	where	where	SCONJ
asodahs-134	294	17	the	the	DET
asodahs-134	294	18	endothelium	endothelium	NOUN
asodahs-134	294	19	loses	lose	VERB
asodahs-134	294	20	its	its	PRON
asodahs-134	294	21	ability	ability	NOUN
asodahs-134	294	22	to	to	PART
asodahs-134	294	23	respond	respond	VERB
asodahs-134	294	24	to	to	ADP
asodahs-134	294	25	stimuli	stimulus	NOUN
asodahs-134	294	26	that	that	PRON
asodahs-134	294	27	would	would	AUX
asodahs-134	294	28	normally	normally	ADV
asodahs-134	294	29	induce	induce	VERB
asodahs-134	294	30	vasodilation	vasodilation	NOUN
asodahs-134	294	31	.	.	PUNCT
asodahs-134	295	1	the	the	DET
asodahs-134	295	2	endothelial	endothelial	ADJ
asodahs-134	295	3	dysfunction	dysfunction	NOUN
asodahs-134	295	4	in	in	ADP
asodahs-134	295	5	scd	scd	PROPN
asodahs-134	295	6	is	be	AUX
asodahs-134	295	7	primarily	primarily	ADV
asodahs-134	295	8	a	a	DET
asodahs-134	295	9	consequence	consequence	NOUN
asodahs-134	295	10	of	of	ADP
asodahs-134	295	11	impaired	impaired	ADJ
asodahs-134	295	12	no	no	DET
asodahs-134	295	13	signaling	signal	VERB
asodahs-134	295	14	due	due	ADP
asodahs-134	295	15	to	to	ADP
asodahs-134	295	16	free	free	ADJ
asodahs-134	295	17	hemoglobin	hemoglobin	NOUN
asodahs-134	295	18	scavenging	scavenge	VERB
asodahs-134	295	19	no	no	PRON
asodahs-134	295	20	,	,	PUNCT
asodahs-134	295	21	oxidative	oxidative	ADJ
asodahs-134	295	22	stress	stress	NOUN
asodahs-134	295	23	,	,	PUNCT
asodahs-134	295	24	and	and	CCONJ
asodahs-134	295	25	reduced	reduce	VERB
asodahs-134	295	26	enos	eno	NOUN
asodahs-134	295	27	activity	activity	NOUN
asodahs-134	295	28	.	.	PUNCT
asodahs-134	296	1	as	as	ADP
asodahs-134	296	2	a	a	DET
asodahs-134	296	3	result	result	NOUN
asodahs-134	296	4	,	,	PUNCT
asodahs-134	296	5	the	the	DET
asodahs-134	296	6	endothelial	endothelial	ADJ
asodahs-134	296	7	cells	cell	NOUN
asodahs-134	296	8	become	become	VERB
asodahs-134	296	9	less	less	ADV
asodahs-134	296	10	capable	capable	ADJ
asodahs-134	296	11	of	of	ADP
asodahs-134	296	12	modulating	modulate	VERB
asodahs-134	296	13	blood	blood	NOUN
asodahs-134	296	14	vessel	vessel	NOUN
asodahs-134	296	15	constriction	constriction	NOUN
asodahs-134	296	16	and	and	CCONJ
asodahs-134	296	17	dilation	dilation	NOUN
asodahs-134	296	18	,	,	PUNCT
asodahs-134	296	19	leading	lead	VERB
asodahs-134	296	20	to	to	ADP
asodahs-134	296	21	a	a	DET
asodahs-134	296	22	persistent	persistent	ADJ
asodahs-134	296	23	state	state	NOUN
asodahs-134	296	24	of	of	ADP
asodahs-134	296	25	vasoconstriction	vasoconstriction	NOUN
asodahs-134	296	26	,	,	PUNCT
asodahs-134	296	27	which	which	PRON
asodahs-134	296	28	impairs	impair	VERB
asodahs-134	296	29	blood	blood	NOUN
asodahs-134	296	30	flow	flow	NOUN
asodahs-134	296	31	.	.	PUNCT
asodahs-134	297	1	this	this	DET
asodahs-134	297	2	diminished	diminish	VERB
asodahs-134	297	3	capacity	capacity	NOUN
asodahs-134	297	4	to	to	PART
asodahs-134	297	5	regulate	regulate	VERB
asodahs-134	297	6	vascular	vascular	ADJ
asodahs-134	297	7	tone	tone	NOUN
asodahs-134	297	8	can	can	AUX
asodahs-134	297	9	result	result	VERB
asodahs-134	297	10	in	in	ADP
asodahs-134	297	11	various	various	ADJ
asodahs-134	297	12	clinical	clinical	ADJ
asodahs-134	297	13	manifestations	manifestation	NOUN
asodahs-134	297	14	,	,	PUNCT
asodahs-134	297	15	including	include	VERB
asodahs-134	297	16	chronic	chronic	ADJ
asodahs-134	297	17	pain	pain	NOUN
asodahs-134	297	18	and	and	CCONJ
asodahs-134	297	19	ischemia	ischemia	NOUN
asodahs-134	297	20	23	23	NUM
asodahs-134	297	21	.	.	X
asodahs-134	298	1	2	2	X
asodahs-134	298	2	.	.	NUM
asodahs-134	298	3	increased	increase	VERB
asodahs-134	298	4	vascular	vascular	ADJ
asodahs-134	298	5	tone	tone	NOUN
asodahs-134	298	6	and	and	CCONJ
asodahs-134	298	7	vasoconstriction	vasoconstriction	NOUN
asodahs-134	298	8	in	in	ADP
asodahs-134	298	9	a	a	DET
asodahs-134	298	10	healthy	healthy	ADJ
asodahs-134	298	11	vasculature	vasculature	NOUN
asodahs-134	298	12	,	,	PUNCT
asodahs-134	298	13	no	no	PRON
asodahs-134	298	14	promotes	promote	VERB
asodahs-134	298	15	vasodilation	vasodilation	NOUN
asodahs-134	298	16	by	by	ADP
asodahs-134	298	17	activating	activate	VERB
asodahs-134	298	18	soluble	soluble	ADJ
asodahs-134	298	19	guanylate	guanylate	NOUN
asodahs-134	298	20	cyclase	cyclase	NOUN
asodahs-134	298	21	in	in	ADP
asodahs-134	298	22	smooth	smooth	ADJ
asodahs-134	298	23	muscle	muscle	NOUN
asodahs-134	298	24	cells	cell	NOUN
asodahs-134	298	25	,	,	PUNCT
asodahs-134	298	26	leading	lead	VERB
asodahs-134	298	27	to	to	ADP
asodahs-134	298	28	the	the	DET
asodahs-134	298	29	relaxation	relaxation	NOUN
asodahs-134	298	30	of	of	ADP
asodahs-134	298	31	vascular	vascular	ADJ
asodahs-134	298	32	smooth	smooth	ADJ
asodahs-134	298	33	muscle	muscle	NOUN
asodahs-134	298	34	and	and	CCONJ
asodahs-134	298	35	subsequent	subsequent	ADJ
asodahs-134	298	36	vessel	vessel	NOUN
asodahs-134	298	37	widening	widening	NOUN
asodahs-134	298	38	.	.	PUNCT
asodahs-134	299	1	in	in	ADP
asodahs-134	299	2	scd	scd	PROPN
asodahs-134	299	3	,	,	PUNCT
asodahs-134	299	4	however	however	ADV
asodahs-134	299	5	,	,	PUNCT
asodahs-134	299	6	the	the	DET
asodahs-134	299	7	depletion	depletion	NOUN
asodahs-134	299	8	of	of	ADP
asodahs-134	299	9	no	no	DET
asodahs-134	299	10	causes	cause	VERB
asodahs-134	299	11	a	a	DET
asodahs-134	299	12	shift	shift	NOUN
asodahs-134	299	13	toward	toward	ADP
asodahs-134	299	14	vasoconstriction	vasoconstriction	NOUN
asodahs-134	299	15	,	,	PUNCT
asodahs-134	299	16	as	as	SCONJ
asodahs-134	299	17	the	the	DET
asodahs-134	299	18	smooth	smooth	ADJ
asodahs-134	299	19	muscle	muscle	NOUN
asodahs-134	299	20	cells	cell	NOUN
asodahs-134	299	21	no	no	ADV
asodahs-134	299	22	longer	long	ADV
asodahs-134	299	23	receive	receive	VERB
asodahs-134	299	24	the	the	DET
asodahs-134	299	25	signal	signal	NOUN
asodahs-134	299	26	to	to	PART
asodahs-134	299	27	relax	relax	VERB
asodahs-134	299	28	.	.	PUNCT
asodahs-134	300	1	this	this	DET
asodahs-134	300	2	increase	increase	NOUN
asodahs-134	300	3	in	in	ADP
asodahs-134	300	4	vascular	vascular	ADJ
asodahs-134	300	5	tone	tone	NOUN
asodahs-134	300	6	can	can	AUX
asodahs-134	300	7	lead	lead	VERB
asodahs-134	300	8	to	to	ADP
asodahs-134	300	9	increased	increase	VERB
asodahs-134	300	10	blood	blood	NOUN
asodahs-134	300	11	pressure	pressure	NOUN
asodahs-134	300	12	and	and	CCONJ
asodahs-134	300	13	reduced	reduce	VERB
asodahs-134	300	14	perfusion	perfusion	NOUN
asodahs-134	300	15	of	of	ADP
asodahs-134	300	16	tissues	tissue	NOUN
asodahs-134	300	17	and	and	CCONJ
asodahs-134	300	18	organs	organ	NOUN
asodahs-134	300	19	.	.	PUNCT
asodahs-134	301	1	the	the	DET
asodahs-134	301	2	reduced	reduce	VERB
asodahs-134	301	3	vasodilation	vasodilation	NOUN
asodahs-134	301	4	also	also	ADV
asodahs-134	301	5	contributes	contribute	VERB
asodahs-134	301	6	to	to	ADP
asodahs-134	301	7	the	the	DET
asodahs-134	301	8	pathogenesis	pathogenesis	NOUN
asodahs-134	301	9	of	of	ADP
asodahs-134	301	10	vaso	vaso	PROPN
asodahs-134	301	11	-	-	PUNCT
asodahs-134	301	12	occlusive	occlusive	ADJ
asodahs-134	301	13	crises	crisis	NOUN
asodahs-134	301	14	,	,	PUNCT
asodahs-134	301	15	which	which	PRON
asodahs-134	301	16	are	be	AUX
asodahs-134	301	17	a	a	DET
asodahs-134	301	18	hallmark	hallmark	NOUN
asodahs-134	301	19	of	of	ADP
asodahs-134	301	20	scd	scd	PROPN
asodahs-134	301	21	.	.	PUNCT
asodahs-134	302	1	during	during	ADP
asodahs-134	302	2	a	a	DET
asodahs-134	302	3	vaso	vaso	NOUN
asodahs-134	302	4	-	-	PUNCT
asodahs-134	302	5	occlusive	occlusive	NOUN
asodahs-134	302	6	crisis	crisis	NOUN
asodahs-134	302	7	,	,	PUNCT
asodahs-134	302	8	blood	blood	NOUN
asodahs-134	302	9	vessels	vessel	NOUN
asodahs-134	302	10	become	become	AUX
asodahs-134	302	11	obstructed	obstruct	VERB
asodahs-134	302	12	due	due	ADP
asodahs-134	302	13	to	to	ADP
asodahs-134	302	14	the	the	DET
asodahs-134	302	15	combination	combination	NOUN
asodahs-134	302	16	of	of	ADP
asodahs-134	302	17	increased	increase	VERB
asodahs-134	302	18	emmanuel	emmanuel	PROPN
asodahs-134	302	19	ifeanyi	ifeanyi	PROPN
asodahs-134	302	20	obeagu	obeagu	PROPN
asodahs-134	302	21	asian	asian	PROPN
asodahs-134	302	22	journal	journal	PROPN
asodahs-134	302	23	of	of	ADP
asodahs-134	302	24	dental	dental	ADJ
asodahs-134	302	25	and	and	CCONJ
asodahs-134	302	26	health	health	NOUN
asodahs-134	302	27	sciences	science	NOUN
asodahs-134	302	28	.	.	PUNCT
asodahs-134	303	1	2025	2025	NUM
asodahs-134	303	2	;	;	PUNCT
asodahs-134	303	3	5(3):6	5(3):6	NUM
asodahs-134	303	4	-	-	SYM
asodahs-134	303	5	12	12	NUM
asodahs-134	304	1	[	[	X
asodahs-134	304	2	9	9	NUM
asodahs-134	304	3	]	]	PUNCT
asodahs-134	304	4	ajdhs.com	ajdhs.com	X
asodahs-134	304	5	viscosity	viscosity	NOUN
asodahs-134	304	6	,	,	PUNCT
asodahs-134	304	7	decreased	decrease	VERB
asodahs-134	304	8	nitric	nitric	ADJ
asodahs-134	304	9	oxide	oxide	NOUN
asodahs-134	304	10	levels	level	NOUN
asodahs-134	304	11	,	,	PUNCT
asodahs-134	304	12	and	and	CCONJ
asodahs-134	304	13	abnormal	abnormal	ADJ
asodahs-134	304	14	red	red	ADJ
asodahs-134	304	15	blood	blood	NOUN
asodahs-134	304	16	cell	cell	NOUN
asodahs-134	304	17	shapes	shape	NOUN
asodahs-134	304	18	,	,	PUNCT
asodahs-134	304	19	leading	lead	VERB
asodahs-134	304	20	to	to	ADP
asodahs-134	304	21	ischemia	ischemia	NOUN
asodahs-134	304	22	and	and	CCONJ
asodahs-134	304	23	pain	pain	NOUN
asodahs-134	304	24	25	25	NUM
asodahs-134	304	25	.	.	PUNCT
asodahs-134	305	1	3	3	X
asodahs-134	305	2	.	.	X
asodahs-134	305	3	promotion	promotion	NOUN
asodahs-134	305	4	of	of	ADP
asodahs-134	305	5	thrombosis	thrombosis	NOUN
asodahs-134	305	6	and	and	CCONJ
asodahs-134	305	7	coagulation	coagulation	NOUN
asodahs-134	305	8	no	no	PRON
asodahs-134	305	9	has	have	VERB
asodahs-134	305	10	anti	anti	ADJ
asodahs-134	305	11	-	-	ADJ
asodahs-134	305	12	thrombotic	thrombotic	ADJ
asodahs-134	305	13	properties	property	NOUN
asodahs-134	305	14	,	,	PUNCT
asodahs-134	305	15	as	as	SCONJ
asodahs-134	305	16	it	it	PRON
asodahs-134	305	17	inhibits	inhibit	VERB
asodahs-134	305	18	platelet	platelet	NOUN
asodahs-134	305	19	aggregation	aggregation	NOUN
asodahs-134	305	20	and	and	CCONJ
asodahs-134	305	21	prevents	prevent	VERB
asodahs-134	305	22	the	the	DET
asodahs-134	305	23	formation	formation	NOUN
asodahs-134	305	24	of	of	ADP
asodahs-134	305	25	blood	blood	NOUN
asodahs-134	305	26	clots	clot	NOUN
asodahs-134	305	27	.	.	PUNCT
asodahs-134	306	1	in	in	ADP
asodahs-134	306	2	the	the	DET
asodahs-134	306	3	absence	absence	NOUN
asodahs-134	306	4	of	of	ADP
asodahs-134	306	5	sufficient	sufficient	ADJ
asodahs-134	306	6	no	no	NOUN
asodahs-134	306	7	,	,	PUNCT
asodahs-134	306	8	there	there	PRON
asodahs-134	306	9	is	be	VERB
asodahs-134	306	10	a	a	DET
asodahs-134	306	11	heightened	heightened	ADJ
asodahs-134	306	12	risk	risk	NOUN
asodahs-134	306	13	of	of	ADP
asodahs-134	306	14	thrombosis	thrombosis	NOUN
asodahs-134	306	15	in	in	ADP
asodahs-134	306	16	scd	scd	NOUN
asodahs-134	306	17	patients	patient	NOUN
asodahs-134	306	18	.	.	PUNCT
asodahs-134	307	1	the	the	DET
asodahs-134	307	2	reduced	reduced	ADJ
asodahs-134	307	3	bioavailability	bioavailability	NOUN
asodahs-134	307	4	of	of	ADP
asodahs-134	307	5	no	no	PRON
asodahs-134	307	6	in	in	ADP
asodahs-134	307	7	scd	scd	PROPN
asodahs-134	307	8	promotes	promote	VERB
asodahs-134	307	9	platelet	platelet	NOUN
asodahs-134	307	10	activation	activation	NOUN
asodahs-134	307	11	,	,	PUNCT
asodahs-134	307	12	increases	increase	VERB
asodahs-134	307	13	endothelial	endothelial	ADJ
asodahs-134	307	14	cell	cell	NOUN
asodahs-134	307	15	adhesion	adhesion	NOUN
asodahs-134	307	16	molecules	molecule	NOUN
asodahs-134	307	17	,	,	PUNCT
asodahs-134	307	18	and	and	CCONJ
asodahs-134	307	19	enhances	enhance	VERB
asodahs-134	307	20	the	the	DET
asodahs-134	307	21	recruitment	recruitment	NOUN
asodahs-134	307	22	of	of	ADP
asodahs-134	307	23	leukocytes	leukocyte	NOUN
asodahs-134	307	24	and	and	CCONJ
asodahs-134	307	25	platelets	platelet	NOUN
asodahs-134	307	26	to	to	ADP
asodahs-134	307	27	the	the	DET
asodahs-134	307	28	site	site	NOUN
asodahs-134	307	29	of	of	ADP
asodahs-134	307	30	injury	injury	NOUN
asodahs-134	307	31	.	.	PUNCT
asodahs-134	308	1	these	these	DET
asodahs-134	308	2	processes	process	NOUN
asodahs-134	308	3	contribute	contribute	VERB
asodahs-134	308	4	to	to	ADP
asodahs-134	308	5	the	the	DET
asodahs-134	308	6	formation	formation	NOUN
asodahs-134	308	7	of	of	ADP
asodahs-134	308	8	microthrombi	microthrombi	NOUN
asodahs-134	308	9	within	within	ADP
asodahs-134	308	10	the	the	DET
asodahs-134	308	11	blood	blood	NOUN
asodahs-134	308	12	vessels	vessel	NOUN
asodahs-134	308	13	,	,	PUNCT
asodahs-134	308	14	which	which	PRON
asodahs-134	308	15	can	can	AUX
asodahs-134	308	16	exacerbate	exacerbate	VERB
asodahs-134	308	17	vaso	vaso	NOUN
asodahs-134	308	18	-	-	PUNCT
asodahs-134	308	19	occlusion	occlusion	NOUN
asodahs-134	308	20	and	and	CCONJ
asodahs-134	308	21	lead	lead	VERB
asodahs-134	308	22	to	to	ADP
asodahs-134	308	23	further	further	ADJ
asodahs-134	308	24	ischemia	ischemia	NOUN
asodahs-134	308	25	.	.	PUNCT
asodahs-134	309	1	additionally	additionally	ADV
asodahs-134	309	2	,	,	PUNCT
asodahs-134	309	3	the	the	DET
asodahs-134	309	4	prothrombotic	prothrombotic	ADJ
asodahs-134	309	5	state	state	NOUN
asodahs-134	309	6	increases	increase	VERB
asodahs-134	309	7	the	the	DET
asodahs-134	309	8	risk	risk	NOUN
asodahs-134	309	9	of	of	ADP
asodahs-134	309	10	stroke	stroke	NOUN
asodahs-134	309	11	,	,	PUNCT
asodahs-134	309	12	myocardial	myocardial	ADJ
asodahs-134	309	13	infarction	infarction	NOUN
asodahs-134	309	14	,	,	PUNCT
asodahs-134	309	15	and	and	CCONJ
asodahs-134	309	16	other	other	ADJ
asodahs-134	309	17	thromboembolic	thromboembolic	ADJ
asodahs-134	309	18	events	event	NOUN
asodahs-134	309	19	in	in	ADP
asodahs-134	309	20	individuals	individual	NOUN
asodahs-134	309	21	with	with	ADP
asodahs-134	309	22	scd	scd	PROPN
asodahs-134	309	23	26	26	NUM
asodahs-134	309	24	.	.	NOUN
asodahs-134	310	1	4	4	NUM
asodahs-134	310	2	.	.	NUM
asodahs-134	310	3	increased	increase	VERB
asodahs-134	310	4	leukocyte	leukocyte	NOUN
asodahs-134	310	5	adhesion	adhesion	NOUN
asodahs-134	310	6	and	and	CCONJ
asodahs-134	310	7	inflammation	inflammation	NOUN
asodahs-134	310	8	no	no	DET
asodahs-134	310	9	plays	play	VERB
asodahs-134	310	10	a	a	DET
asodahs-134	310	11	critical	critical	ADJ
asodahs-134	310	12	role	role	NOUN
asodahs-134	310	13	in	in	ADP
asodahs-134	310	14	modulating	modulate	VERB
asodahs-134	310	15	the	the	DET
asodahs-134	310	16	inflammatory	inflammatory	ADJ
asodahs-134	310	17	response	response	NOUN
asodahs-134	310	18	within	within	ADP
asodahs-134	310	19	the	the	DET
asodahs-134	310	20	vasculature	vasculature	NOUN
asodahs-134	310	21	by	by	ADP
asodahs-134	310	22	inhibiting	inhibit	VERB
asodahs-134	310	23	the	the	DET
asodahs-134	310	24	adhesion	adhesion	NOUN
asodahs-134	310	25	of	of	ADP
asodahs-134	310	26	leukocytes	leukocyte	NOUN
asodahs-134	310	27	to	to	ADP
asodahs-134	310	28	the	the	DET
asodahs-134	310	29	endothelial	endothelial	ADJ
asodahs-134	310	30	cells	cell	NOUN
asodahs-134	310	31	.	.	PUNCT
asodahs-134	311	1	in	in	ADP
asodahs-134	311	2	the	the	DET
asodahs-134	311	3	absence	absence	NOUN
asodahs-134	311	4	of	of	ADP
asodahs-134	311	5	adequate	adequate	ADJ
asodahs-134	311	6	no	no	DET
asodahs-134	311	7	levels	level	NOUN
asodahs-134	311	8	,	,	PUNCT
asodahs-134	311	9	the	the	DET
asodahs-134	311	10	inflammatory	inflammatory	ADJ
asodahs-134	311	11	response	response	NOUN
asodahs-134	311	12	is	be	AUX
asodahs-134	311	13	dysregulated	dysregulate	VERB
asodahs-134	311	14	,	,	PUNCT
asodahs-134	311	15	and	and	CCONJ
asodahs-134	311	16	there	there	PRON
asodahs-134	311	17	is	be	VERB
asodahs-134	311	18	increased	increase	VERB
asodahs-134	311	19	adhesion	adhesion	NOUN
asodahs-134	311	20	of	of	ADP
asodahs-134	311	21	leukocytes	leukocyte	NOUN
asodahs-134	311	22	to	to	ADP
asodahs-134	311	23	the	the	DET
asodahs-134	311	24	endothelium	endothelium	NOUN
asodahs-134	311	25	.	.	PUNCT
asodahs-134	312	1	this	this	PRON
asodahs-134	312	2	exacerbates	exacerbate	VERB
asodahs-134	312	3	the	the	DET
asodahs-134	312	4	inflammatory	inflammatory	ADJ
asodahs-134	312	5	processes	process	NOUN
asodahs-134	312	6	in	in	ADP
asodahs-134	312	7	scd	scd	NOUN
asodahs-134	312	8	,	,	PUNCT
asodahs-134	312	9	promoting	promote	VERB
asodahs-134	312	10	further	further	ADJ
asodahs-134	312	11	endothelial	endothelial	ADJ
asodahs-134	312	12	injury	injury	NOUN
asodahs-134	312	13	and	and	CCONJ
asodahs-134	312	14	contributing	contribute	VERB
asodahs-134	312	15	to	to	ADP
asodahs-134	312	16	the	the	DET
asodahs-134	312	17	development	development	NOUN
asodahs-134	312	18	of	of	ADP
asodahs-134	312	19	chronic	chronic	ADJ
asodahs-134	312	20	inflammation	inflammation	NOUN
asodahs-134	312	21	.	.	PUNCT
asodahs-134	313	1	the	the	DET
asodahs-134	313	2	enhanced	enhanced	ADJ
asodahs-134	313	3	leukocyte	leukocyte	NOUN
asodahs-134	313	4	adhesion	adhesion	NOUN
asodahs-134	313	5	also	also	ADV
asodahs-134	313	6	facilitates	facilitate	VERB
asodahs-134	313	7	the	the	DET
asodahs-134	313	8	progression	progression	NOUN
asodahs-134	313	9	of	of	ADP
asodahs-134	313	10	tissue	tissue	NOUN
asodahs-134	313	11	damage	damage	NOUN
asodahs-134	313	12	and	and	CCONJ
asodahs-134	313	13	vascular	vascular	ADJ
asodahs-134	313	14	occlusion	occlusion	NOUN
asodahs-134	313	15	,	,	PUNCT
asodahs-134	313	16	which	which	PRON
asodahs-134	313	17	underlie	underlie	VERB
asodahs-134	313	18	many	many	ADJ
asodahs-134	313	19	of	of	ADP
asodahs-134	313	20	the	the	DET
asodahs-134	313	21	acute	acute	ADJ
asodahs-134	313	22	and	and	CCONJ
asodahs-134	313	23	chronic	chronic	ADJ
asodahs-134	313	24	complications	complication	NOUN
asodahs-134	313	25	seen	see	VERB
asodahs-134	313	26	in	in	ADP
asodahs-134	313	27	scd	scd	NOUN
asodahs-134	313	28	patients	patient	NOUN
asodahs-134	313	29	,	,	PUNCT
asodahs-134	313	30	such	such	ADJ
asodahs-134	313	31	as	as	ADP
asodahs-134	313	32	organ	organ	NOUN
asodahs-134	313	33	damage	damage	NOUN
asodahs-134	313	34	,	,	PUNCT
asodahs-134	313	35	stroke	stroke	NOUN
asodahs-134	313	36	,	,	PUNCT
asodahs-134	313	37	and	and	CCONJ
asodahs-134	313	38	pulmonary	pulmonary	ADJ
asodahs-134	313	39	hypertension	hypertension	NOUN
asodahs-134	313	40	27	27	NUM
asodahs-134	313	41	.	.	PUNCT
asodahs-134	314	1	5	5	X
asodahs-134	314	2	.	.	X
asodahs-134	314	3	pulmonary	pulmonary	ADJ
asodahs-134	314	4	hypertension	hypertension	NOUN
asodahs-134	314	5	pulmonary	pulmonary	ADJ
asodahs-134	314	6	hypertension	hypertension	NOUN
asodahs-134	314	7	(	(	PUNCT
asodahs-134	314	8	ph	ph	NOUN
asodahs-134	314	9	)	)	PUNCT
asodahs-134	314	10	is	be	AUX
asodahs-134	314	11	a	a	DET
asodahs-134	314	12	common	common	ADJ
asodahs-134	314	13	and	and	CCONJ
asodahs-134	314	14	severe	severe	ADJ
asodahs-134	314	15	complication	complication	NOUN
asodahs-134	314	16	in	in	ADP
asodahs-134	314	17	scd	scd	PROPN
asodahs-134	314	18	,	,	PUNCT
asodahs-134	314	19	characterized	characterize	VERB
asodahs-134	314	20	by	by	ADP
asodahs-134	314	21	elevated	elevated	ADJ
asodahs-134	314	22	pressure	pressure	NOUN
asodahs-134	314	23	in	in	ADP
asodahs-134	314	24	the	the	DET
asodahs-134	314	25	pulmonary	pulmonary	ADJ
asodahs-134	314	26	arteries	artery	NOUN
asodahs-134	314	27	.	.	PUNCT
asodahs-134	315	1	no	no	DET
asodahs-134	315	2	deficiency	deficiency	NOUN
asodahs-134	315	3	plays	play	VERB
asodahs-134	315	4	a	a	DET
asodahs-134	315	5	central	central	ADJ
asodahs-134	315	6	role	role	NOUN
asodahs-134	315	7	in	in	ADP
asodahs-134	315	8	the	the	DET
asodahs-134	315	9	pathogenesis	pathogenesis	NOUN
asodahs-134	315	10	of	of	ADP
asodahs-134	315	11	ph	ph	PROPN
asodahs-134	315	12	in	in	ADP
asodahs-134	315	13	scd	scd	PROPN
asodahs-134	315	14	.	.	PUNCT
asodahs-134	316	1	in	in	ADP
asodahs-134	316	2	the	the	DET
asodahs-134	316	3	pulmonary	pulmonary	ADJ
asodahs-134	316	4	circulation	circulation	NOUN
asodahs-134	316	5	,	,	PUNCT
asodahs-134	316	6	no	no	PRON
asodahs-134	316	7	normally	normally	ADV
asodahs-134	316	8	helps	help	VERB
asodahs-134	316	9	regulate	regulate	VERB
asodahs-134	316	10	vascular	vascular	ADJ
asodahs-134	316	11	tone	tone	NOUN
asodahs-134	316	12	and	and	CCONJ
asodahs-134	316	13	maintain	maintain	VERB
asodahs-134	316	14	a	a	DET
asodahs-134	316	15	low	low	ADJ
asodahs-134	316	16	-	-	PUNCT
asodahs-134	316	17	pressure	pressure	NOUN
asodahs-134	316	18	environment	environment	NOUN
asodahs-134	316	19	.	.	PUNCT
asodahs-134	317	1	however	however	ADV
asodahs-134	317	2	,	,	PUNCT
asodahs-134	317	3	in	in	ADP
asodahs-134	317	4	the	the	DET
asodahs-134	317	5	setting	setting	NOUN
asodahs-134	317	6	of	of	ADP
asodahs-134	317	7	no	no	DET
asodahs-134	317	8	depletion	depletion	NOUN
asodahs-134	317	9	,	,	PUNCT
asodahs-134	317	10	there	there	PRON
asodahs-134	317	11	is	be	VERB
asodahs-134	317	12	increased	increase	VERB
asodahs-134	317	13	pulmonary	pulmonary	ADJ
asodahs-134	317	14	vascular	vascular	ADJ
asodahs-134	317	15	resistance	resistance	NOUN
asodahs-134	317	16	,	,	PUNCT
asodahs-134	317	17	which	which	PRON
asodahs-134	317	18	leads	lead	VERB
asodahs-134	317	19	to	to	ADP
asodahs-134	317	20	right	right	ADJ
asodahs-134	317	21	heart	heart	NOUN
asodahs-134	317	22	strain	strain	NOUN
asodahs-134	317	23	and	and	CCONJ
asodahs-134	317	24	eventually	eventually	ADV
asodahs-134	317	25	right	right	ADJ
asodahs-134	317	26	heart	heart	NOUN
asodahs-134	317	27	failure	failure	NOUN
asodahs-134	317	28	.	.	PUNCT
asodahs-134	318	1	the	the	DET
asodahs-134	318	2	combination	combination	NOUN
asodahs-134	318	3	of	of	ADP
asodahs-134	318	4	chronic	chronic	ADJ
asodahs-134	318	5	hemolysis	hemolysis	NOUN
asodahs-134	318	6	,	,	PUNCT
asodahs-134	318	7	oxidative	oxidative	ADJ
asodahs-134	318	8	stress	stress	NOUN
asodahs-134	318	9	,	,	PUNCT
asodahs-134	318	10	and	and	CCONJ
asodahs-134	318	11	impaired	impaired	ADJ
asodahs-134	318	12	enos	eno	NOUN
asodahs-134	318	13	function	function	NOUN
asodahs-134	318	14	in	in	ADP
asodahs-134	318	15	scd	scd	PROPN
asodahs-134	318	16	promotes	promote	VERB
asodahs-134	318	17	vasoconstriction	vasoconstriction	NOUN
asodahs-134	318	18	in	in	ADP
asodahs-134	318	19	the	the	DET
asodahs-134	318	20	pulmonary	pulmonary	ADJ
asodahs-134	318	21	vasculature	vasculature	NOUN
asodahs-134	318	22	,	,	PUNCT
asodahs-134	318	23	worsening	worsen	VERB
asodahs-134	318	24	pulmonary	pulmonary	ADJ
asodahs-134	318	25	hypertension	hypertension	NOUN
asodahs-134	318	26	.	.	PUNCT
asodahs-134	319	1	ph	ph	PROPN
asodahs-134	319	2	is	be	AUX
asodahs-134	319	3	a	a	DET
asodahs-134	319	4	significant	significant	ADJ
asodahs-134	319	5	contributor	contributor	NOUN
asodahs-134	319	6	to	to	ADP
asodahs-134	319	7	morbidity	morbidity	NOUN
asodahs-134	319	8	and	and	CCONJ
asodahs-134	319	9	mortality	mortality	NOUN
asodahs-134	319	10	in	in	ADP
asodahs-134	319	11	scd	scd	PROPN
asodahs-134	319	12	patients	patient	NOUN
asodahs-134	319	13	,	,	PUNCT
asodahs-134	319	14	with	with	ADP
asodahs-134	319	15	a	a	DET
asodahs-134	319	16	poor	poor	ADJ
asodahs-134	319	17	prognosis	prognosis	NOUN
asodahs-134	319	18	if	if	SCONJ
asodahs-134	319	19	left	leave	VERB
asodahs-134	319	20	untreated	untreated	ADJ
asodahs-134	319	21	28	28	NUM
asodahs-134	319	22	.	.	PUNCT
asodahs-134	320	1	6	6	NUM
asodahs-134	320	2	.	.	NOUN
asodahs-134	320	3	end	end	NOUN
asodahs-134	320	4	-	-	PUNCT
asodahs-134	320	5	organ	organ	NOUN
asodahs-134	320	6	damage	damage	NOUN
asodahs-134	320	7	the	the	DET
asodahs-134	320	8	vascular	vascular	ADJ
asodahs-134	320	9	consequences	consequence	NOUN
asodahs-134	320	10	of	of	ADP
asodahs-134	320	11	no	no	DET
asodahs-134	320	12	deficiency	deficiency	NOUN
asodahs-134	320	13	extend	extend	VERB
asodahs-134	320	14	to	to	ADP
asodahs-134	320	15	various	various	ADJ
asodahs-134	320	16	organs	organ	NOUN
asodahs-134	320	17	,	,	PUNCT
asodahs-134	320	18	where	where	SCONJ
asodahs-134	320	19	the	the	DET
asodahs-134	320	20	impaired	impaired	ADJ
asodahs-134	320	21	blood	blood	NOUN
asodahs-134	320	22	flow	flow	NOUN
asodahs-134	320	23	and	and	CCONJ
asodahs-134	320	24	increased	increase	VERB
asodahs-134	320	25	vascular	vascular	ADJ
asodahs-134	320	26	tone	tone	NOUN
asodahs-134	320	27	contribute	contribute	VERB
asodahs-134	320	28	to	to	ADP
asodahs-134	320	29	end	end	NOUN
asodahs-134	320	30	-	-	PUNCT
asodahs-134	320	31	organ	organ	NOUN
asodahs-134	320	32	damage	damage	NOUN
asodahs-134	320	33	.	.	PUNCT
asodahs-134	321	1	chronic	chronic	ADJ
asodahs-134	321	2	kidney	kidney	NOUN
asodahs-134	321	3	disease	disease	NOUN
asodahs-134	321	4	,	,	PUNCT
asodahs-134	321	5	stroke	stroke	NOUN
asodahs-134	321	6	,	,	PUNCT
asodahs-134	321	7	and	and	CCONJ
asodahs-134	321	8	liver	liver	NOUN
asodahs-134	321	9	dysfunction	dysfunction	NOUN
asodahs-134	321	10	are	be	AUX
asodahs-134	321	11	common	common	ADJ
asodahs-134	321	12	complications	complication	NOUN
asodahs-134	321	13	in	in	ADP
asodahs-134	321	14	individuals	individual	NOUN
asodahs-134	321	15	with	with	ADP
asodahs-134	321	16	scd	scd	PROPN
asodahs-134	321	17	,	,	PUNCT
asodahs-134	321	18	and	and	CCONJ
asodahs-134	321	19	the	the	DET
asodahs-134	321	20	reduced	reduced	ADJ
asodahs-134	321	21	no	no	DET
asodahs-134	321	22	bioavailability	bioavailability	NOUN
asodahs-134	321	23	exacerbates	exacerbate	VERB
asodahs-134	321	24	these	these	DET
asodahs-134	321	25	conditions	condition	NOUN
asodahs-134	321	26	.	.	PUNCT
asodahs-134	322	1	in	in	ADP
asodahs-134	322	2	the	the	DET
asodahs-134	322	3	kidneys	kidney	NOUN
asodahs-134	322	4	,	,	PUNCT
asodahs-134	322	5	the	the	DET
asodahs-134	322	6	increased	increase	VERB
asodahs-134	322	7	vascular	vascular	ADJ
asodahs-134	322	8	tone	tone	NOUN
asodahs-134	322	9	and	and	CCONJ
asodahs-134	322	10	reduced	reduced	ADJ
asodahs-134	322	11	perfusion	perfusion	NOUN
asodahs-134	322	12	can	can	AUX
asodahs-134	322	13	lead	lead	VERB
asodahs-134	322	14	to	to	ADP
asodahs-134	322	15	glomerular	glomerular	ADJ
asodahs-134	322	16	injury	injury	NOUN
asodahs-134	322	17	and	and	CCONJ
asodahs-134	322	18	tubulointerstitial	tubulointerstitial	ADJ
asodahs-134	322	19	fibrosis	fibrosis	NOUN
asodahs-134	322	20	,	,	PUNCT
asodahs-134	322	21	ultimately	ultimately	ADV
asodahs-134	322	22	resulting	result	VERB
asodahs-134	322	23	in	in	ADP
asodahs-134	322	24	chronic	chronic	ADJ
asodahs-134	322	25	kidney	kidney	NOUN
asodahs-134	322	26	disease	disease	NOUN
asodahs-134	322	27	.	.	PUNCT
asodahs-134	323	1	similarly	similarly	ADV
asodahs-134	323	2	,	,	PUNCT
asodahs-134	323	3	the	the	DET
asodahs-134	323	4	combination	combination	NOUN
asodahs-134	323	5	of	of	ADP
asodahs-134	323	6	vaso	vaso	NOUN
asodahs-134	323	7	-	-	PUNCT
asodahs-134	323	8	occlusion	occlusion	NOUN
asodahs-134	323	9	and	and	CCONJ
asodahs-134	323	10	endothelial	endothelial	ADJ
asodahs-134	323	11	dysfunction	dysfunction	NOUN
asodahs-134	323	12	in	in	ADP
asodahs-134	323	13	the	the	DET
asodahs-134	323	14	brain	brain	NOUN
asodahs-134	323	15	increases	increase	VERB
asodahs-134	323	16	the	the	DET
asodahs-134	323	17	risk	risk	NOUN
asodahs-134	323	18	of	of	ADP
asodahs-134	323	19	ischemic	ischemic	ADJ
asodahs-134	323	20	stroke	stroke	NOUN
asodahs-134	323	21	in	in	ADP
asodahs-134	323	22	scd	scd	PROPN
asodahs-134	323	23	patients	patient	NOUN
asodahs-134	323	24	.	.	PUNCT
asodahs-134	324	1	organ	organ	NOUN
asodahs-134	324	2	damage	damage	NOUN
asodahs-134	324	3	in	in	ADP
asodahs-134	324	4	scd	scd	PROPN
asodahs-134	324	5	is	be	AUX
asodahs-134	324	6	multifactorial	multifactorial	ADJ
asodahs-134	324	7	but	but	CCONJ
asodahs-134	324	8	is	be	AUX
asodahs-134	324	9	aggravated	aggravate	VERB
asodahs-134	324	10	by	by	ADP
asodahs-134	324	11	the	the	DET
asodahs-134	324	12	diminished	diminished	ADJ
asodahs-134	324	13	capacity	capacity	NOUN
asodahs-134	324	14	of	of	ADP
asodahs-134	324	15	no	no	PRON
asodahs-134	324	16	to	to	PART
asodahs-134	324	17	protect	protect	VERB
asodahs-134	324	18	against	against	ADP
asodahs-134	324	19	vascular	vascular	ADJ
asodahs-134	324	20	injury	injury	NOUN
asodahs-134	324	21	and	and	CCONJ
asodahs-134	324	22	maintain	maintain	VERB
asodahs-134	324	23	normal	normal	ADJ
asodahs-134	324	24	blood	blood	NOUN
asodahs-134	324	25	flow	flow	NOUN
asodahs-134	324	26	29	29	NUM
asodahs-134	324	27	.	.	PUNCT
asodahs-134	325	1	therapeutic	therapeutic	ADJ
asodahs-134	325	2	strategies	strategy	NOUN
asodahs-134	325	3	to	to	PART
asodahs-134	325	4	restore	restore	VERB
asodahs-134	325	5	nitric	nitric	ADJ
asodahs-134	325	6	oxide	oxide	NOUN
asodahs-134	325	7	bioavailability	bioavailability	NOUN
asodahs-134	325	8	in	in	ADP
asodahs-134	325	9	sickle	sickle	NOUN
asodahs-134	325	10	cell	cell	NOUN
asodahs-134	325	11	disease	disease	NOUN
asodahs-134	325	12	(	(	PUNCT
asodahs-134	325	13	scd	scd	NOUN
asodahs-134	325	14	)	)	PUNCT
asodahs-134	325	15	restoring	restore	VERB
asodahs-134	325	16	nitric	nitric	ADJ
asodahs-134	325	17	oxide	oxide	NOUN
asodahs-134	325	18	(	(	PUNCT
asodahs-134	325	19	no	no	NOUN
asodahs-134	325	20	)	)	PUNCT
asodahs-134	325	21	bioavailability	bioavailability	NOUN
asodahs-134	325	22	is	be	AUX
asodahs-134	325	23	an	an	DET
asodahs-134	325	24	important	important	ADJ
asodahs-134	325	25	therapeutic	therapeutic	ADJ
asodahs-134	325	26	target	target	NOUN
asodahs-134	325	27	in	in	ADP
asodahs-134	325	28	sickle	sickle	NOUN
asodahs-134	325	29	cell	cell	NOUN
asodahs-134	325	30	disease	disease	NOUN
asodahs-134	325	31	(	(	PUNCT
asodahs-134	325	32	scd	scd	NOUN
asodahs-134	325	33	)	)	PUNCT
asodahs-134	325	34	,	,	PUNCT
asodahs-134	325	35	as	as	ADP
asodahs-134	325	36	the	the	DET
asodahs-134	325	37	deficiency	deficiency	NOUN
asodahs-134	325	38	of	of	ADP
asodahs-134	325	39	no	no	DET
asodahs-134	325	40	contributes	contribute	VERB
asodahs-134	325	41	significantly	significantly	ADV
asodahs-134	325	42	to	to	ADP
asodahs-134	325	43	the	the	DET
asodahs-134	325	44	vascular	vascular	ADJ
asodahs-134	325	45	dysfunction	dysfunction	NOUN
asodahs-134	325	46	,	,	PUNCT
asodahs-134	325	47	inflammation	inflammation	NOUN
asodahs-134	325	48	,	,	PUNCT
asodahs-134	325	49	and	and	CCONJ
asodahs-134	325	50	thrombotic	thrombotic	ADJ
asodahs-134	325	51	complications	complication	NOUN
asodahs-134	325	52	characteristic	characteristic	ADJ
asodahs-134	325	53	of	of	ADP
asodahs-134	325	54	the	the	DET
asodahs-134	325	55	disease	disease	NOUN
asodahs-134	325	56	.	.	PUNCT
asodahs-134	326	1	various	various	ADJ
asodahs-134	326	2	therapeutic	therapeutic	ADJ
asodahs-134	326	3	strategies	strategy	NOUN
asodahs-134	326	4	have	have	AUX
asodahs-134	326	5	been	be	AUX
asodahs-134	326	6	explored	explore	VERB
asodahs-134	326	7	to	to	PART
asodahs-134	326	8	enhance	enhance	VERB
asodahs-134	326	9	no	no	DET
asodahs-134	326	10	production	production	NOUN
asodahs-134	326	11	,	,	PUNCT
asodahs-134	326	12	minimize	minimize	VERB
asodahs-134	326	13	its	its	PRON
asodahs-134	326	14	scavenging	scavenging	NOUN
asodahs-134	326	15	,	,	PUNCT
asodahs-134	326	16	and	and	CCONJ
asodahs-134	326	17	improve	improve	VERB
asodahs-134	326	18	endothelial	endothelial	ADJ
asodahs-134	326	19	function	function	NOUN
asodahs-134	326	20	in	in	ADP
asodahs-134	326	21	individuals	individual	NOUN
asodahs-134	326	22	with	with	ADP
asodahs-134	326	23	scd	scd	PROPN
asodahs-134	326	24	.	.	PUNCT
asodahs-134	327	1	these	these	DET
asodahs-134	327	2	strategies	strategy	NOUN
asodahs-134	327	3	involve	involve	VERB
asodahs-134	327	4	both	both	DET
asodahs-134	327	5	pharmacological	pharmacological	ADJ
asodahs-134	327	6	interventions	intervention	NOUN
asodahs-134	327	7	and	and	CCONJ
asodahs-134	327	8	lifestyle	lifestyle	NOUN
asodahs-134	327	9	modifications	modification	NOUN
asodahs-134	327	10	aimed	aim	VERB
asodahs-134	327	11	at	at	ADP
asodahs-134	327	12	restoring	restore	VERB
asodahs-134	327	13	endothelial	endothelial	ADJ
asodahs-134	327	14	homeostasis	homeostasis	NOUN
asodahs-134	327	15	,	,	PUNCT
asodahs-134	327	16	reducing	reduce	VERB
asodahs-134	327	17	oxidative	oxidative	ADJ
asodahs-134	327	18	stress	stress	NOUN
asodahs-134	327	19	,	,	PUNCT
asodahs-134	327	20	and	and	CCONJ
asodahs-134	327	21	improving	improve	VERB
asodahs-134	327	22	vascular	vascular	ADJ
asodahs-134	327	23	function	function	NOUN
asodahs-134	327	24	.	.	PUNCT
asodahs-134	328	1	1	1	X
asodahs-134	328	2	.	.	X
asodahs-134	328	3	l	l	NOUN
asodahs-134	328	4	-	-	PUNCT
asodahs-134	328	5	arginine	arginine	NOUN
asodahs-134	328	6	supplementation	supplementation	NOUN
asodahs-134	328	7	l	l	NOUN
asodahs-134	328	8	-	-	NOUN
asodahs-134	328	9	arginine	arginine	NOUN
asodahs-134	328	10	is	be	AUX
asodahs-134	328	11	the	the	DET
asodahs-134	328	12	amino	amino	NOUN
asodahs-134	328	13	acid	acid	NOUN
asodahs-134	328	14	substrate	substrate	NOUN
asodahs-134	328	15	required	require	VERB
asodahs-134	328	16	for	for	ADP
asodahs-134	328	17	the	the	DET
asodahs-134	328	18	production	production	NOUN
asodahs-134	328	19	of	of	ADP
asodahs-134	328	20	no	no	PRON
asodahs-134	328	21	by	by	ADP
asodahs-134	328	22	endothelial	endothelial	ADJ
asodahs-134	328	23	nitric	nitric	ADJ
asodahs-134	328	24	oxide	oxide	NOUN
asodahs-134	328	25	synthase	synthase	NOUN
asodahs-134	328	26	(	(	PUNCT
asodahs-134	328	27	enos	enos	PROPN
asodahs-134	328	28	)	)	PUNCT
asodahs-134	328	29	.	.	PUNCT
asodahs-134	329	1	in	in	ADP
asodahs-134	329	2	scd	scd	PROPN
asodahs-134	329	3	,	,	PUNCT
asodahs-134	329	4	the	the	DET
asodahs-134	329	5	bioavailability	bioavailability	NOUN
asodahs-134	329	6	of	of	ADP
asodahs-134	329	7	l	l	NOUN
asodahs-134	329	8	-	-	NOUN
asodahs-134	329	9	arginine	arginine	NOUN
asodahs-134	329	10	is	be	AUX
asodahs-134	329	11	often	often	ADV
asodahs-134	329	12	reduced	reduce	VERB
asodahs-134	329	13	due	due	ADP
asodahs-134	329	14	to	to	ADP
asodahs-134	329	15	the	the	DET
asodahs-134	329	16	increased	increase	VERB
asodahs-134	329	17	activity	activity	NOUN
asodahs-134	329	18	of	of	ADP
asodahs-134	329	19	arginase	arginase	NOUN
asodahs-134	329	20	,	,	PUNCT
asodahs-134	329	21	which	which	PRON
asodahs-134	329	22	hydrolyzes	hydrolyze	VERB
asodahs-134	329	23	l	l	NOUN
asodahs-134	329	24	-	-	NOUN
asodahs-134	329	25	arginine	arginine	NOUN
asodahs-134	329	26	into	into	ADP
asodahs-134	329	27	ornithine	ornithine	NOUN
asodahs-134	329	28	.	.	PUNCT
asodahs-134	330	1	supplementing	supplement	VERB
asodahs-134	330	2	with	with	ADP
asodahs-134	330	3	l	l	NOUN
asodahs-134	330	4	-	-	NOUN
asodahs-134	330	5	arginine	arginine	NOUN
asodahs-134	330	6	has	have	AUX
asodahs-134	330	7	been	be	AUX
asodahs-134	330	8	investigated	investigate	VERB
asodahs-134	330	9	as	as	ADP
asodahs-134	330	10	a	a	DET
asodahs-134	330	11	strategy	strategy	NOUN
asodahs-134	330	12	to	to	PART
asodahs-134	330	13	restore	restore	VERB
asodahs-134	330	14	no	no	DET
asodahs-134	330	15	production	production	NOUN
asodahs-134	330	16	by	by	ADP
asodahs-134	330	17	providing	provide	VERB
asodahs-134	330	18	an	an	DET
asodahs-134	330	19	additional	additional	ADJ
asodahs-134	330	20	substrate	substrate	NOUN
asodahs-134	330	21	for	for	ADP
asodahs-134	330	22	enos	eno	NOUN
asodahs-134	330	23	.	.	PUNCT
asodahs-134	331	1	clinical	clinical	ADJ
asodahs-134	331	2	studies	study	NOUN
asodahs-134	331	3	have	have	AUX
asodahs-134	331	4	shown	show	VERB
asodahs-134	331	5	that	that	SCONJ
asodahs-134	331	6	larginine	larginine	ADJ
asodahs-134	331	7	supplementation	supplementation	NOUN
asodahs-134	331	8	can	can	AUX
asodahs-134	331	9	improve	improve	VERB
asodahs-134	331	10	endothelial	endothelial	ADJ
asodahs-134	331	11	function	function	NOUN
asodahs-134	331	12	,	,	PUNCT
asodahs-134	331	13	reduce	reduce	VERB
asodahs-134	331	14	pulmonary	pulmonary	ADJ
asodahs-134	331	15	artery	artery	NOUN
asodahs-134	331	16	pressure	pressure	NOUN
asodahs-134	331	17	,	,	PUNCT
asodahs-134	331	18	and	and	CCONJ
asodahs-134	331	19	enhance	enhance	VERB
asodahs-134	331	20	vasodilation	vasodilation	NOUN
asodahs-134	331	21	in	in	ADP
asodahs-134	331	22	scd	scd	NOUN
asodahs-134	331	23	patients	patient	NOUN
asodahs-134	331	24	.	.	PUNCT
asodahs-134	332	1	while	while	SCONJ
asodahs-134	332	2	the	the	DET
asodahs-134	332	3	results	result	NOUN
asodahs-134	332	4	are	be	AUX
asodahs-134	332	5	promising	promise	VERB
asodahs-134	332	6	,	,	PUNCT
asodahs-134	332	7	the	the	DET
asodahs-134	332	8	effect	effect	NOUN
asodahs-134	332	9	of	of	ADP
asodahs-134	332	10	l	l	NOUN
asodahs-134	332	11	-	-	PUNCT
asodahs-134	332	12	arginine	arginine	NOUN
asodahs-134	332	13	supplementation	supplementation	NOUN
asodahs-134	332	14	may	may	AUX
asodahs-134	332	15	be	be	AUX
asodahs-134	332	16	variable	variable	ADJ
asodahs-134	332	17	,	,	PUNCT
asodahs-134	332	18	and	and	CCONJ
asodahs-134	332	19	its	its	PRON
asodahs-134	332	20	use	use	NOUN
asodahs-134	332	21	should	should	AUX
asodahs-134	332	22	be	be	AUX
asodahs-134	332	23	considered	consider	VERB
asodahs-134	332	24	alongside	alongside	ADP
asodahs-134	332	25	other	other	ADJ
asodahs-134	332	26	therapies	therapy	NOUN
asodahs-134	332	27	aimed	aim	VERB
asodahs-134	332	28	at	at	ADP
asodahs-134	332	29	reducing	reduce	VERB
asodahs-134	332	30	oxidative	oxidative	ADJ
asodahs-134	332	31	stress	stress	NOUN
asodahs-134	332	32	and	and	CCONJ
asodahs-134	332	33	inflammation	inflammation	NOUN
asodahs-134	332	34	30	30	NUM
asodahs-134	332	35	.	.	PUNCT
asodahs-134	333	1	2	2	NUM
asodahs-134	333	2	.	.	NOUN
asodahs-134	333	3	nitrate	nitrate	NOUN
asodahs-134	333	4	therapy	therapy	NOUN
asodahs-134	333	5	nitrate	nitrate	NOUN
asodahs-134	333	6	therapy	therapy	NOUN
asodahs-134	333	7	is	be	AUX
asodahs-134	333	8	another	another	DET
asodahs-134	333	9	strategy	strategy	NOUN
asodahs-134	333	10	to	to	PART
asodahs-134	333	11	restore	restore	VERB
asodahs-134	333	12	no	no	DET
asodahs-134	333	13	bioavailability	bioavailability	NOUN
asodahs-134	333	14	in	in	ADP
asodahs-134	333	15	scd	scd	PROPN
asodahs-134	333	16	.	.	PUNCT
asodahs-134	334	1	nitrates	nitrate	NOUN
asodahs-134	334	2	are	be	AUX
asodahs-134	334	3	metabolized	metabolize	VERB
asodahs-134	334	4	to	to	PART
asodahs-134	334	5	release	release	VERB
asodahs-134	334	6	no	no	DET
asodahs-134	334	7	or	or	CCONJ
asodahs-134	334	8	no	no	ADV
asodahs-134	334	9	-	-	PUNCT
asodahs-134	334	10	like	like	ADJ
asodahs-134	334	11	species	specie	NOUN
asodahs-134	334	12	,	,	PUNCT
asodahs-134	334	13	which	which	PRON
asodahs-134	334	14	can	can	AUX
asodahs-134	334	15	help	help	VERB
asodahs-134	334	16	restore	restore	VERB
asodahs-134	334	17	vasodilation	vasodilation	NOUN
asodahs-134	334	18	and	and	CCONJ
asodahs-134	334	19	reduce	reduce	VERB
asodahs-134	334	20	vascular	vascular	ADJ
asodahs-134	334	21	tone	tone	NOUN
asodahs-134	334	22	.	.	PUNCT
asodahs-134	335	1	organic	organic	ADJ
asodahs-134	335	2	nitrates	nitrate	NOUN
asodahs-134	335	3	,	,	PUNCT
asodahs-134	335	4	such	such	ADJ
asodahs-134	335	5	as	as	ADP
asodahs-134	335	6	nitroglycerin	nitroglycerin	NOUN
asodahs-134	335	7	,	,	PUNCT
asodahs-134	335	8	and	and	CCONJ
asodahs-134	335	9	inorganic	inorganic	ADJ
asodahs-134	335	10	nitrates	nitrate	NOUN
asodahs-134	335	11	,	,	PUNCT
asodahs-134	335	12	such	such	ADJ
asodahs-134	335	13	as	as	ADP
asodahs-134	335	14	sodium	sodium	NOUN
asodahs-134	335	15	nitrite	nitrite	NOUN
asodahs-134	335	16	,	,	PUNCT
asodahs-134	335	17	have	have	AUX
asodahs-134	335	18	been	be	AUX
asodahs-134	335	19	explored	explore	VERB
asodahs-134	335	20	in	in	ADP
asodahs-134	335	21	preclinical	preclinical	ADJ
asodahs-134	335	22	and	and	CCONJ
asodahs-134	335	23	clinical	clinical	ADJ
asodahs-134	335	24	studies	study	NOUN
asodahs-134	335	25	for	for	ADP
asodahs-134	335	26	their	their	PRON
asodahs-134	335	27	ability	ability	NOUN
asodahs-134	335	28	to	to	PART
asodahs-134	335	29	increase	increase	VERB
asodahs-134	335	30	no	no	DET
asodahs-134	335	31	levels	level	NOUN
asodahs-134	335	32	in	in	ADP
asodahs-134	335	33	the	the	DET
asodahs-134	335	34	circulation	circulation	NOUN
asodahs-134	335	35	.	.	PUNCT
asodahs-134	336	1	in	in	ADP
asodahs-134	336	2	scd	scd	PROPN
asodahs-134	336	3	,	,	PUNCT
asodahs-134	336	4	nitrate	nitrate	NOUN
asodahs-134	336	5	therapy	therapy	NOUN
asodahs-134	336	6	may	may	AUX
asodahs-134	336	7	improve	improve	VERB
asodahs-134	336	8	endothelial	endothelial	ADJ
asodahs-134	336	9	function	function	NOUN
asodahs-134	336	10	,	,	PUNCT
asodahs-134	336	11	reduce	reduce	VERB
asodahs-134	336	12	pulmonary	pulmonary	ADJ
asodahs-134	336	13	hypertension	hypertension	NOUN
asodahs-134	336	14	,	,	PUNCT
asodahs-134	336	15	and	and	CCONJ
asodahs-134	336	16	alleviate	alleviate	VERB
asodahs-134	336	17	symptoms	symptom	NOUN
asodahs-134	336	18	of	of	ADP
asodahs-134	336	19	vaso	vaso	NOUN
asodahs-134	336	20	-	-	PUNCT
asodahs-134	336	21	occlusive	occlusive	ADJ
asodahs-134	336	22	crises	crisis	NOUN
asodahs-134	336	23	by	by	ADP
asodahs-134	336	24	enhancing	enhance	VERB
asodahs-134	336	25	blood	blood	NOUN
asodahs-134	336	26	flow	flow	NOUN
asodahs-134	336	27	and	and	CCONJ
asodahs-134	336	28	reducing	reduce	VERB
asodahs-134	336	29	ischemia	ischemia	NOUN
asodahs-134	336	30	.	.	PUNCT
asodahs-134	337	1	however	however	ADV
asodahs-134	337	2	,	,	PUNCT
asodahs-134	337	3	the	the	DET
asodahs-134	337	4	long	long	ADJ
asodahs-134	337	5	-	-	PUNCT
asodahs-134	337	6	term	term	NOUN
asodahs-134	337	7	use	use	NOUN
asodahs-134	337	8	of	of	ADP
asodahs-134	337	9	nitrates	nitrate	NOUN
asodahs-134	337	10	in	in	ADP
asodahs-134	337	11	scd	scd	PROPN
asodahs-134	337	12	requires	require	VERB
asodahs-134	337	13	caution	caution	NOUN
asodahs-134	337	14	due	due	ADP
asodahs-134	337	15	to	to	ADP
asodahs-134	337	16	the	the	DET
asodahs-134	337	17	potential	potential	NOUN
asodahs-134	337	18	for	for	ADP
asodahs-134	337	19	tolerance	tolerance	NOUN
asodahs-134	337	20	development	development	NOUN
asodahs-134	337	21	and	and	CCONJ
asodahs-134	337	22	adverse	adverse	ADJ
asodahs-134	337	23	effects	effect	NOUN
asodahs-134	337	24	on	on	ADP
asodahs-134	337	25	blood	blood	NOUN
asodahs-134	337	26	pressure	pressure	NOUN
asodahs-134	337	27	regulation	regulation	NOUN
asodahs-134	337	28	31	31	NUM
asodahs-134	337	29	.	.	PUNCT
asodahs-134	338	1	3	3	X
asodahs-134	338	2	.	.	X
asodahs-134	338	3	antioxidant	antioxidant	ADJ
asodahs-134	338	4	therapies	therapy	NOUN
asodahs-134	338	5	since	since	SCONJ
asodahs-134	338	6	oxidative	oxidative	ADJ
asodahs-134	338	7	stress	stress	NOUN
asodahs-134	338	8	is	be	AUX
asodahs-134	338	9	a	a	DET
asodahs-134	338	10	key	key	ADJ
asodahs-134	338	11	contributor	contributor	NOUN
asodahs-134	338	12	to	to	ADP
asodahs-134	338	13	no	no	DET
asodahs-134	338	14	depletion	depletion	NOUN
asodahs-134	338	15	in	in	ADP
asodahs-134	338	16	scd	scd	PROPN
asodahs-134	338	17	,	,	PUNCT
asodahs-134	338	18	antioxidants	antioxidant	NOUN
asodahs-134	338	19	that	that	PRON
asodahs-134	338	20	neutralize	neutralize	VERB
asodahs-134	338	21	reactive	reactive	ADJ
asodahs-134	338	22	oxygen	oxygen	NOUN
asodahs-134	338	23	species	specie	NOUN
asodahs-134	338	24	(	(	PUNCT
asodahs-134	338	25	ros	ros	PROPN
asodahs-134	338	26	)	)	PUNCT
asodahs-134	338	27	and	and	CCONJ
asodahs-134	338	28	prevent	prevent	VERB
asodahs-134	338	29	endothelial	endothelial	ADJ
asodahs-134	338	30	cell	cell	NOUN
asodahs-134	338	31	damage	damage	NOUN
asodahs-134	338	32	have	have	AUX
asodahs-134	338	33	been	be	AUX
asodahs-134	338	34	investigated	investigate	VERB
asodahs-134	338	35	as	as	ADP
asodahs-134	338	36	therapeutic	therapeutic	ADJ
asodahs-134	338	37	options	option	NOUN
asodahs-134	338	38	.	.	PUNCT
asodahs-134	339	1	vitamin	vitamin	NOUN
asodahs-134	339	2	e	e	NOUN
asodahs-134	339	3	,	,	PUNCT
asodahs-134	339	4	a	a	DET
asodahs-134	339	5	potent	potent	ADJ
asodahs-134	339	6	antioxidant	antioxidant	NOUN
asodahs-134	339	7	,	,	PUNCT
asodahs-134	339	8	has	have	AUX
asodahs-134	339	9	been	be	AUX
asodahs-134	339	10	shown	show	VERB
asodahs-134	339	11	to	to	PART
asodahs-134	339	12	reduce	reduce	VERB
asodahs-134	339	13	oxidative	oxidative	ADJ
asodahs-134	339	14	stress	stress	NOUN
asodahs-134	339	15	in	in	ADP
asodahs-134	339	16	scd	scd	NOUN
asodahs-134	339	17	and	and	CCONJ
asodahs-134	339	18	may	may	AUX
asodahs-134	339	19	help	help	VERB
asodahs-134	339	20	improve	improve	VERB
asodahs-134	339	21	no	no	DET
asodahs-134	339	22	bioavailability	bioavailability	NOUN
asodahs-134	339	23	.	.	PUNCT
asodahs-134	340	1	other	other	ADJ
asodahs-134	340	2	antioxidant	antioxidant	ADJ
asodahs-134	340	3	compounds	compound	NOUN
asodahs-134	340	4	,	,	PUNCT
asodahs-134	340	5	such	such	ADJ
asodahs-134	340	6	emmanuel	emmanuel	PROPN
asodahs-134	340	7	ifeanyi	ifeanyi	PROPN
asodahs-134	340	8	obeagu	obeagu	PROPN
asodahs-134	340	9	asian	asian	PROPN
asodahs-134	340	10	journal	journal	PROPN
asodahs-134	340	11	of	of	ADP
asodahs-134	340	12	dental	dental	ADJ
asodahs-134	340	13	and	and	CCONJ
asodahs-134	340	14	health	health	NOUN
asodahs-134	340	15	sciences	science	NOUN
asodahs-134	340	16	.	.	PUNCT
asodahs-134	340	17	2025	2025	NUM
asodahs-134	340	18	;	;	PUNCT
asodahs-134	340	19	5(3):6	5(3):6	NUM
asodahs-134	340	20	-	-	SYM
asodahs-134	340	21	12	12	NUM
asodahs-134	341	1	[	[	X
asodahs-134	341	2	10	10	NUM
asodahs-134	341	3	]	]	PUNCT
asodahs-134	341	4	ajdhs.com	ajdhs.com	X
asodahs-134	341	5	as	as	ADP
asodahs-134	341	6	n	n	X
asodahs-134	341	7	-	-	PUNCT
asodahs-134	341	8	acetylcysteine	acetylcysteine	NOUN
asodahs-134	341	9	(	(	PUNCT
asodahs-134	341	10	nac	nac	PROPN
asodahs-134	341	11	)	)	PUNCT
asodahs-134	341	12	and	and	CCONJ
asodahs-134	341	13	polyphenols	polyphenol	NOUN
asodahs-134	341	14	(	(	PUNCT
asodahs-134	341	15	found	find	VERB
asodahs-134	341	16	in	in	ADP
asodahs-134	341	17	fruits	fruit	NOUN
asodahs-134	341	18	,	,	PUNCT
asodahs-134	341	19	vegetables	vegetable	NOUN
asodahs-134	341	20	,	,	PUNCT
asodahs-134	341	21	and	and	CCONJ
asodahs-134	341	22	tea	tea	NOUN
asodahs-134	341	23	)	)	PUNCT
asodahs-134	341	24	,	,	PUNCT
asodahs-134	341	25	have	have	AUX
asodahs-134	341	26	demonstrated	demonstrate	VERB
asodahs-134	341	27	potential	potential	NOUN
asodahs-134	341	28	in	in	ADP
asodahs-134	341	29	reducing	reduce	VERB
asodahs-134	341	30	ros	ro	NOUN
asodahs-134	341	31	and	and	CCONJ
asodahs-134	341	32	improving	improve	VERB
asodahs-134	341	33	endothelial	endothelial	ADJ
asodahs-134	341	34	function	function	NOUN
asodahs-134	341	35	.	.	PUNCT
asodahs-134	342	1	these	these	DET
asodahs-134	342	2	antioxidants	antioxidant	NOUN
asodahs-134	342	3	may	may	AUX
asodahs-134	342	4	indirectly	indirectly	ADV
asodahs-134	342	5	enhance	enhance	VERB
asodahs-134	342	6	no	no	DET
asodahs-134	342	7	signaling	signal	VERB
asodahs-134	342	8	by	by	ADP
asodahs-134	342	9	decreasing	decrease	VERB
asodahs-134	342	10	the	the	DET
asodahs-134	342	11	oxidative	oxidative	ADJ
asodahs-134	342	12	damage	damage	NOUN
asodahs-134	342	13	to	to	ADP
asodahs-134	342	14	enos	enos	PROPN
asodahs-134	342	15	and	and	CCONJ
asodahs-134	342	16	other	other	ADJ
asodahs-134	342	17	endothelial	endothelial	ADJ
asodahs-134	342	18	cell	cell	NOUN
asodahs-134	342	19	components	component	NOUN
asodahs-134	342	20	.	.	PUNCT
asodahs-134	343	1	the	the	DET
asodahs-134	343	2	use	use	NOUN
asodahs-134	343	3	of	of	ADP
asodahs-134	343	4	antioxidants	antioxidant	NOUN
asodahs-134	343	5	as	as	ADP
asodahs-134	343	6	adjunctive	adjunctive	ADJ
asodahs-134	343	7	therapies	therapy	NOUN
asodahs-134	343	8	may	may	AUX
asodahs-134	343	9	be	be	AUX
asodahs-134	343	10	effective	effective	ADJ
asodahs-134	343	11	in	in	ADP
asodahs-134	343	12	managing	manage	VERB
asodahs-134	343	13	vascular	vascular	ADJ
asodahs-134	343	14	dysfunction	dysfunction	NOUN
asodahs-134	343	15	and	and	CCONJ
asodahs-134	343	16	improving	improve	VERB
asodahs-134	343	17	overall	overall	ADJ
asodahs-134	343	18	patient	patient	ADJ
asodahs-134	343	19	health	health	NOUN
asodahs-134	343	20	in	in	ADP
asodahs-134	343	21	scd	scd	PROPN
asodahs-134	343	22	32	32	NUM
asodahs-134	343	23	.	.	PUNCT
asodahs-134	344	1	4	4	NUM
asodahs-134	344	2	.	.	NOUN
asodahs-134	344	3	hydroxyurea	hydroxyurea	PROPN
asodahs-134	344	4	therapy	therapy	PROPN
asodahs-134	344	5	hydroxyurea	hydroxyurea	PROPN
asodahs-134	344	6	,	,	PUNCT
asodahs-134	344	7	a	a	DET
asodahs-134	344	8	standard	standard	ADJ
asodahs-134	344	9	therapeutic	therapeutic	ADJ
asodahs-134	344	10	agent	agent	NOUN
asodahs-134	344	11	in	in	ADP
asodahs-134	344	12	scd	scd	PROPN
asodahs-134	344	13	,	,	PUNCT
asodahs-134	344	14	has	have	AUX
asodahs-134	344	15	demonstrated	demonstrate	VERB
asodahs-134	344	16	multiple	multiple	ADJ
asodahs-134	344	17	benefits	benefit	NOUN
asodahs-134	344	18	beyond	beyond	ADP
asodahs-134	344	19	its	its	PRON
asodahs-134	344	20	effects	effect	NOUN
asodahs-134	344	21	on	on	ADP
asodahs-134	344	22	hemoglobin	hemoglobin	NOUN
asodahs-134	344	23	f	f	PROPN
asodahs-134	344	24	(	(	PUNCT
asodahs-134	344	25	hbf	hbf	PROPN
asodahs-134	344	26	)	)	PUNCT
asodahs-134	344	27	induction	induction	NOUN
asodahs-134	344	28	.	.	PUNCT
asodahs-134	345	1	one	one	NUM
asodahs-134	345	2	of	of	ADP
asodahs-134	345	3	its	its	PRON
asodahs-134	345	4	potential	potential	ADJ
asodahs-134	345	5	benefits	benefit	NOUN
asodahs-134	345	6	is	be	AUX
asodahs-134	345	7	its	its	PRON
asodahs-134	345	8	ability	ability	NOUN
asodahs-134	345	9	to	to	PART
asodahs-134	345	10	increase	increase	VERB
asodahs-134	345	11	no	no	DET
asodahs-134	345	12	production	production	NOUN
asodahs-134	345	13	.	.	PUNCT
asodahs-134	346	1	hydroxyurea	hydroxyurea	PROPN
asodahs-134	346	2	has	have	AUX
asodahs-134	346	3	been	be	AUX
asodahs-134	346	4	shown	show	VERB
asodahs-134	346	5	to	to	PART
asodahs-134	346	6	stimulate	stimulate	VERB
asodahs-134	346	7	enos	eno	NOUN
asodahs-134	346	8	activity	activity	NOUN
asodahs-134	346	9	and	and	CCONJ
asodahs-134	346	10	enhance	enhance	VERB
asodahs-134	346	11	no	no	DET
asodahs-134	346	12	bioavailability	bioavailability	NOUN
asodahs-134	346	13	in	in	ADP
asodahs-134	346	14	patients	patient	NOUN
asodahs-134	346	15	with	with	ADP
asodahs-134	346	16	scd	scd	PROPN
asodahs-134	346	17	.	.	PUNCT
asodahs-134	347	1	this	this	DET
asodahs-134	347	2	effect	effect	NOUN
asodahs-134	347	3	is	be	AUX
asodahs-134	347	4	thought	think	VERB
asodahs-134	347	5	to	to	PART
asodahs-134	347	6	be	be	AUX
asodahs-134	347	7	mediated	mediate	VERB
asodahs-134	347	8	by	by	ADP
asodahs-134	347	9	the	the	DET
asodahs-134	347	10	reduction	reduction	NOUN
asodahs-134	347	11	of	of	ADP
asodahs-134	347	12	hemolysis	hemolysis	NOUN
asodahs-134	347	13	and	and	CCONJ
asodahs-134	347	14	the	the	DET
asodahs-134	347	15	associated	associated	ADJ
asodahs-134	347	16	release	release	NOUN
asodahs-134	347	17	of	of	ADP
asodahs-134	347	18	free	free	ADJ
asodahs-134	347	19	hemoglobin	hemoglobin	NOUN
asodahs-134	347	20	,	,	PUNCT
asodahs-134	347	21	which	which	PRON
asodahs-134	347	22	scavenges	scavenge	VERB
asodahs-134	347	23	no	no	INTJ
asodahs-134	347	24	.	.	PUNCT
asodahs-134	348	1	additionally	additionally	ADV
asodahs-134	348	2	,	,	PUNCT
asodahs-134	348	3	hydroxyurea	hydroxyurea	PROPN
asodahs-134	348	4	can	can	AUX
asodahs-134	348	5	decrease	decrease	VERB
asodahs-134	348	6	oxidative	oxidative	ADJ
asodahs-134	348	7	stress	stress	NOUN
asodahs-134	348	8	,	,	PUNCT
asodahs-134	348	9	thereby	thereby	ADV
asodahs-134	348	10	protecting	protect	VERB
asodahs-134	348	11	endothelial	endothelial	ADJ
asodahs-134	348	12	cells	cell	NOUN
asodahs-134	348	13	and	and	CCONJ
asodahs-134	348	14	promoting	promote	VERB
asodahs-134	348	15	vascular	vascular	ADJ
asodahs-134	348	16	health	health	NOUN
asodahs-134	348	17	.	.	PUNCT
asodahs-134	349	1	the	the	DET
asodahs-134	349	2	combination	combination	NOUN
asodahs-134	349	3	of	of	ADP
asodahs-134	349	4	these	these	DET
asodahs-134	349	5	effects	effect	NOUN
asodahs-134	349	6	may	may	AUX
asodahs-134	349	7	help	help	VERB
asodahs-134	349	8	mitigate	mitigate	VERB
asodahs-134	349	9	the	the	DET
asodahs-134	349	10	vascular	vascular	ADJ
asodahs-134	349	11	complications	complication	NOUN
asodahs-134	349	12	of	of	ADP
asodahs-134	349	13	scd	scd	PROPN
asodahs-134	349	14	,	,	PUNCT
asodahs-134	349	15	including	include	VERB
asodahs-134	349	16	pulmonary	pulmonary	ADJ
asodahs-134	349	17	hypertension	hypertension	NOUN
asodahs-134	349	18	and	and	CCONJ
asodahs-134	349	19	stroke	stroke	NOUN
asodahs-134	349	20	.	.	PUNCT
asodahs-134	350	1	hydroxyurea	hydroxyurea	PROPN
asodahs-134	350	2	remains	remain	VERB
asodahs-134	350	3	one	one	NUM
asodahs-134	350	4	of	of	ADP
asodahs-134	350	5	the	the	DET
asodahs-134	350	6	cornerstones	cornerstone	NOUN
asodahs-134	350	7	of	of	ADP
asodahs-134	350	8	scd	scd	NOUN
asodahs-134	350	9	treatment	treatment	NOUN
asodahs-134	350	10	due	due	ADP
asodahs-134	350	11	to	to	ADP
asodahs-134	350	12	its	its	PRON
asodahs-134	350	13	ability	ability	NOUN
asodahs-134	350	14	to	to	PART
asodahs-134	350	15	reduce	reduce	VERB
asodahs-134	350	16	the	the	DET
asodahs-134	350	17	frequency	frequency	NOUN
asodahs-134	350	18	of	of	ADP
asodahs-134	350	19	vaso	vaso	NOUN
asodahs-134	350	20	-	-	PUNCT
asodahs-134	350	21	occlusive	occlusive	ADJ
asodahs-134	350	22	crises	crisis	NOUN
asodahs-134	350	23	and	and	CCONJ
asodahs-134	350	24	improve	improve	VERB
asodahs-134	350	25	overall	overall	ADJ
asodahs-134	350	26	patient	patient	ADJ
asodahs-134	350	27	outcomes	outcome	NOUN
asodahs-134	350	28	33	33	NUM
asodahs-134	350	29	.	.	NOUN
asodahs-134	351	1	5	5	NUM
asodahs-134	351	2	.	.	X
asodahs-134	351	3	gene	gene	NOUN
asodahs-134	351	4	therapy	therapy	NOUN
asodahs-134	351	5	and	and	CCONJ
asodahs-134	351	6	cellular	cellular	ADJ
asodahs-134	351	7	approaches	approach	NOUN
asodahs-134	351	8	emerging	emerge	VERB
asodahs-134	351	9	gene	gene	NOUN
asodahs-134	351	10	therapy	therapy	NOUN
asodahs-134	351	11	and	and	CCONJ
asodahs-134	351	12	cellular	cellular	ADJ
asodahs-134	351	13	approaches	approach	NOUN
asodahs-134	351	14	offer	offer	VERB
asodahs-134	351	15	promising	promise	VERB
asodahs-134	351	16	potential	potential	NOUN
asodahs-134	351	17	for	for	ADP
asodahs-134	351	18	restoring	restore	VERB
asodahs-134	351	19	no	no	DET
asodahs-134	351	20	bioavailability	bioavailability	NOUN
asodahs-134	351	21	in	in	ADP
asodahs-134	351	22	scd	scd	PROPN
asodahs-134	351	23	.	.	PUNCT
asodahs-134	352	1	recent	recent	ADJ
asodahs-134	352	2	advances	advance	NOUN
asodahs-134	352	3	in	in	ADP
asodahs-134	352	4	gene	gene	NOUN
asodahs-134	352	5	editing	edit	VERB
asodahs-134	352	6	technologies	technology	NOUN
asodahs-134	352	7	,	,	PUNCT
asodahs-134	352	8	such	such	ADJ
asodahs-134	352	9	as	as	ADP
asodahs-134	352	10	crispr	crispr	NOUN
asodahs-134	352	11	-	-	PUNCT
asodahs-134	352	12	cas9	cas9	NOUN
asodahs-134	352	13	,	,	PUNCT
asodahs-134	352	14	have	have	AUX
asodahs-134	352	15	made	make	VERB
asodahs-134	352	16	it	it	PRON
asodahs-134	352	17	possible	possible	ADJ
asodahs-134	352	18	to	to	PART
asodahs-134	352	19	correct	correct	VERB
asodahs-134	352	20	the	the	DET
asodahs-134	352	21	underlying	underlie	VERB
asodahs-134	352	22	genetic	genetic	ADJ
asodahs-134	352	23	mutation	mutation	NOUN
asodahs-134	352	24	in	in	ADP
asodahs-134	352	25	hemoglobin	hemoglobin	NOUN
asodahs-134	352	26	(	(	PUNCT
asodahs-134	352	27	hbs	hbs	PROPN
asodahs-134	352	28	)	)	PUNCT
asodahs-134	352	29	or	or	CCONJ
asodahs-134	352	30	to	to	PART
asodahs-134	352	31	induce	induce	VERB
asodahs-134	352	32	the	the	DET
asodahs-134	352	33	expression	expression	NOUN
asodahs-134	352	34	of	of	ADP
asodahs-134	352	35	fetal	fetal	ADJ
asodahs-134	352	36	hemoglobin	hemoglobin	NOUN
asodahs-134	352	37	(	(	PUNCT
asodahs-134	352	38	hbf	hbf	PROPN
asodahs-134	352	39	)	)	PUNCT
asodahs-134	352	40	,	,	PUNCT
asodahs-134	352	41	which	which	PRON
asodahs-134	352	42	reduces	reduce	VERB
asodahs-134	352	43	the	the	DET
asodahs-134	352	44	sickling	sickling	NOUN
asodahs-134	352	45	of	of	ADP
asodahs-134	352	46	red	red	ADJ
asodahs-134	352	47	blood	blood	NOUN
asodahs-134	352	48	cells	cell	NOUN
asodahs-134	352	49	and	and	CCONJ
asodahs-134	352	50	alleviates	alleviate	VERB
asodahs-134	352	51	hemolysis	hemolysis	NOUN
asodahs-134	352	52	.	.	PUNCT
asodahs-134	353	1	by	by	ADP
asodahs-134	353	2	reducing	reduce	VERB
asodahs-134	353	3	hemolysis	hemolysis	NOUN
asodahs-134	353	4	and	and	CCONJ
asodahs-134	353	5	increasing	increase	VERB
asodahs-134	353	6	hbf	hbf	PROPN
asodahs-134	353	7	levels	level	NOUN
asodahs-134	353	8	,	,	PUNCT
asodahs-134	353	9	gene	gene	NOUN
asodahs-134	353	10	therapy	therapy	NOUN
asodahs-134	353	11	may	may	AUX
asodahs-134	353	12	reduce	reduce	VERB
asodahs-134	353	13	the	the	DET
asodahs-134	353	14	amount	amount	NOUN
asodahs-134	353	15	of	of	ADP
asodahs-134	353	16	free	free	ADJ
asodahs-134	353	17	hemoglobin	hemoglobin	NOUN
asodahs-134	353	18	available	available	ADJ
asodahs-134	353	19	to	to	PART
asodahs-134	353	20	scavenge	scavenge	VERB
asodahs-134	353	21	no	no	INTJ
asodahs-134	353	22	.	.	PUNCT
asodahs-134	354	1	additionally	additionally	ADV
asodahs-134	354	2	,	,	PUNCT
asodahs-134	354	3	stem	stem	VERB
asodahs-134	354	4	cell	cell	NOUN
asodahs-134	354	5	-	-	PUNCT
asodahs-134	354	6	based	base	VERB
asodahs-134	354	7	therapies	therapy	NOUN
asodahs-134	354	8	,	,	PUNCT
asodahs-134	354	9	including	include	VERB
asodahs-134	354	10	the	the	DET
asodahs-134	354	11	use	use	NOUN
asodahs-134	354	12	of	of	ADP
asodahs-134	354	13	autologous	autologous	ADJ
asodahs-134	354	14	stem	stem	NOUN
asodahs-134	354	15	cells	cell	NOUN
asodahs-134	354	16	genetically	genetically	ADV
asodahs-134	354	17	modified	modify	VERB
asodahs-134	354	18	to	to	PART
asodahs-134	354	19	express	express	VERB
asodahs-134	354	20	hbf	hbf	PROPN
asodahs-134	354	21	,	,	PUNCT
asodahs-134	354	22	may	may	AUX
asodahs-134	354	23	improve	improve	VERB
asodahs-134	354	24	blood	blood	NOUN
asodahs-134	354	25	flow	flow	NOUN
asodahs-134	354	26	and	and	CCONJ
asodahs-134	354	27	endothelial	endothelial	ADJ
asodahs-134	354	28	function	function	NOUN
asodahs-134	354	29	by	by	ADP
asodahs-134	354	30	reducing	reduce	VERB
asodahs-134	354	31	hemolysis	hemolysis	NOUN
asodahs-134	354	32	and	and	CCONJ
asodahs-134	354	33	inflammation	inflammation	NOUN
asodahs-134	354	34	.	.	PUNCT
asodahs-134	355	1	while	while	SCONJ
asodahs-134	355	2	these	these	DET
asodahs-134	355	3	approaches	approach	NOUN
asodahs-134	355	4	are	be	AUX
asodahs-134	355	5	still	still	ADV
asodahs-134	355	6	in	in	ADP
asodahs-134	355	7	experimental	experimental	ADJ
asodahs-134	355	8	stages	stage	NOUN
asodahs-134	355	9	,	,	PUNCT
asodahs-134	355	10	they	they	PRON
asodahs-134	355	11	hold	hold	VERB
asodahs-134	355	12	great	great	ADJ
asodahs-134	355	13	promise	promise	NOUN
asodahs-134	355	14	for	for	ADP
asodahs-134	355	15	long	long	ADJ
asodahs-134	355	16	-	-	PUNCT
asodahs-134	355	17	term	term	NOUN
asodahs-134	355	18	management	management	NOUN
asodahs-134	355	19	of	of	ADP
asodahs-134	355	20	scd	scd	PROPN
asodahs-134	355	21	and	and	CCONJ
asodahs-134	355	22	its	its	PRON
asodahs-134	355	23	associated	associated	ADJ
asodahs-134	355	24	vascular	vascular	ADJ
asodahs-134	355	25	complications	complication	NOUN
asodahs-134	355	26	34	34	NUM
asodahs-134	355	27	.	.	NOUN
asodahs-134	355	28	6	6	NUM
asodahs-134	355	29	.	.	X
asodahs-134	355	30	phosphodiesterase	phosphodiesterase	NOUN
asodahs-134	355	31	type	type	NOUN
asodahs-134	355	32	5	5	NUM
asodahs-134	355	33	(	(	PUNCT
asodahs-134	355	34	pde5	pde5	NOUN
asodahs-134	355	35	)	)	PUNCT
asodahs-134	355	36	inhibitors	inhibitor	NOUN
asodahs-134	355	37	pde5	pde5	NOUN
asodahs-134	355	38	inhibitors	inhibitor	NOUN
asodahs-134	355	39	,	,	PUNCT
asodahs-134	355	40	such	such	ADJ
asodahs-134	355	41	as	as	ADP
asodahs-134	355	42	sildenafil	sildenafil	NOUN
asodahs-134	355	43	,	,	PUNCT
asodahs-134	355	44	are	be	AUX
asodahs-134	355	45	known	know	VERB
asodahs-134	355	46	to	to	PART
asodahs-134	355	47	enhance	enhance	VERB
asodahs-134	355	48	no	no	DET
asodahs-134	355	49	signaling	signal	VERB
asodahs-134	355	50	by	by	ADP
asodahs-134	355	51	inhibiting	inhibit	VERB
asodahs-134	355	52	the	the	DET
asodahs-134	355	53	breakdown	breakdown	NOUN
asodahs-134	355	54	of	of	ADP
asodahs-134	355	55	cyclic	cyclic	ADJ
asodahs-134	355	56	guanosine	guanosine	NOUN
asodahs-134	355	57	monophosphate	monophosphate	NOUN
asodahs-134	355	58	(	(	PUNCT
asodahs-134	355	59	cgmp	cgmp	PROPN
asodahs-134	355	60	)	)	PUNCT
asodahs-134	355	61	,	,	PUNCT
asodahs-134	355	62	which	which	PRON
asodahs-134	355	63	is	be	AUX
asodahs-134	355	64	produced	produce	VERB
asodahs-134	355	65	in	in	ADP
asodahs-134	355	66	response	response	NOUN
asodahs-134	355	67	to	to	ADP
asodahs-134	355	68	no	no	DET
asodahs-134	355	69	activation	activation	NOUN
asodahs-134	355	70	of	of	ADP
asodahs-134	355	71	guanylate	guanylate	NOUN
asodahs-134	355	72	cyclase	cyclase	NOUN
asodahs-134	355	73	.	.	PUNCT
asodahs-134	356	1	by	by	ADP
asodahs-134	356	2	preserving	preserve	VERB
asodahs-134	356	3	cgmp	cgmp	PROPN
asodahs-134	356	4	levels	level	NOUN
asodahs-134	356	5	,	,	PUNCT
asodahs-134	356	6	pde5	pde5	NOUN
asodahs-134	356	7	inhibitors	inhibitor	NOUN
asodahs-134	356	8	can	can	AUX
asodahs-134	356	9	enhance	enhance	VERB
asodahs-134	356	10	the	the	DET
asodahs-134	356	11	vasodilatory	vasodilatory	ADJ
asodahs-134	356	12	effects	effect	NOUN
asodahs-134	356	13	of	of	ADP
asodahs-134	356	14	no	no	PRON
asodahs-134	356	15	and	and	CCONJ
asodahs-134	356	16	improve	improve	VERB
asodahs-134	356	17	endothelial	endothelial	ADJ
asodahs-134	356	18	function	function	NOUN
asodahs-134	356	19	.	.	PUNCT
asodahs-134	357	1	in	in	ADP
asodahs-134	357	2	scd	scd	PROPN
asodahs-134	357	3	,	,	PUNCT
asodahs-134	357	4	pde5	pde5	NOUN
asodahs-134	357	5	inhibitors	inhibitor	NOUN
asodahs-134	357	6	have	have	AUX
asodahs-134	357	7	been	be	AUX
asodahs-134	357	8	explored	explore	VERB
asodahs-134	357	9	as	as	ADP
asodahs-134	357	10	potential	potential	ADJ
asodahs-134	357	11	therapies	therapy	NOUN
asodahs-134	357	12	for	for	ADP
asodahs-134	357	13	pulmonary	pulmonary	ADJ
asodahs-134	357	14	hypertension	hypertension	NOUN
asodahs-134	357	15	and	and	CCONJ
asodahs-134	357	16	other	other	ADJ
asodahs-134	357	17	forms	form	NOUN
asodahs-134	357	18	of	of	ADP
asodahs-134	357	19	vascular	vascular	ADJ
asodahs-134	357	20	dysfunction	dysfunction	NOUN
asodahs-134	357	21	.	.	PUNCT
asodahs-134	358	1	clinical	clinical	ADJ
asodahs-134	358	2	studies	study	NOUN
asodahs-134	358	3	have	have	AUX
asodahs-134	358	4	shown	show	VERB
asodahs-134	358	5	that	that	SCONJ
asodahs-134	358	6	sildenafil	sildenafil	NOUN
asodahs-134	358	7	and	and	CCONJ
asodahs-134	358	8	other	other	ADJ
asodahs-134	358	9	pde5	pde5	NOUN
asodahs-134	358	10	inhibitors	inhibitor	NOUN
asodahs-134	358	11	can	can	AUX
asodahs-134	358	12	improve	improve	VERB
asodahs-134	358	13	exercise	exercise	NOUN
asodahs-134	358	14	capacity	capacity	NOUN
asodahs-134	358	15	,	,	PUNCT
asodahs-134	358	16	reduce	reduce	VERB
asodahs-134	358	17	pulmonary	pulmonary	ADJ
asodahs-134	358	18	artery	artery	NOUN
asodahs-134	358	19	pressure	pressure	NOUN
asodahs-134	358	20	,	,	PUNCT
asodahs-134	358	21	and	and	CCONJ
asodahs-134	358	22	alleviate	alleviate	VERB
asodahs-134	358	23	symptoms	symptom	NOUN
asodahs-134	358	24	of	of	ADP
asodahs-134	358	25	pulmonary	pulmonary	ADJ
asodahs-134	358	26	hypertension	hypertension	NOUN
asodahs-134	358	27	in	in	ADP
asodahs-134	358	28	scd	scd	NOUN
asodahs-134	358	29	patients	patient	NOUN
asodahs-134	358	30	.	.	PUNCT
asodahs-134	359	1	while	while	SCONJ
asodahs-134	359	2	these	these	DET
asodahs-134	359	3	drugs	drug	NOUN
asodahs-134	359	4	are	be	AUX
asodahs-134	359	5	generally	generally	ADV
asodahs-134	359	6	well	well	ADV
asodahs-134	359	7	tolerated	tolerate	VERB
asodahs-134	359	8	,	,	PUNCT
asodahs-134	359	9	careful	careful	ADJ
asodahs-134	359	10	monitoring	monitoring	NOUN
asodahs-134	359	11	is	be	AUX
asodahs-134	359	12	necessary	necessary	ADJ
asodahs-134	359	13	due	due	ADJ
asodahs-134	359	14	to	to	ADP
asodahs-134	359	15	potential	potential	ADJ
asodahs-134	359	16	side	side	NOUN
asodahs-134	359	17	effects	effect	NOUN
asodahs-134	359	18	and	and	CCONJ
asodahs-134	359	19	interactions	interaction	NOUN
asodahs-134	359	20	with	with	ADP
asodahs-134	359	21	other	other	ADJ
asodahs-134	359	22	medications	medication	NOUN
asodahs-134	359	23	used	use	VERB
asodahs-134	359	24	in	in	ADP
asodahs-134	359	25	scd	scd	PROPN
asodahs-134	359	26	management	management	NOUN
asodahs-134	359	27	35	35	NUM
asodahs-134	359	28	-	-	SYM
asodahs-134	359	29	36	36	NUM
asodahs-134	359	30	.	.	PUNCT
asodahs-134	360	1	7	7	X
asodahs-134	360	2	.	.	PUNCT
asodahs-134	360	3	lifestyle	lifestyle	NOUN
asodahs-134	360	4	modifications	modification	NOUN
asodahs-134	360	5	in	in	ADP
asodahs-134	360	6	addition	addition	NOUN
asodahs-134	360	7	to	to	ADP
asodahs-134	360	8	pharmacological	pharmacological	ADJ
asodahs-134	360	9	interventions	intervention	NOUN
asodahs-134	360	10	,	,	PUNCT
asodahs-134	360	11	lifestyle	lifestyle	NOUN
asodahs-134	360	12	modifications	modification	NOUN
asodahs-134	360	13	can	can	AUX
asodahs-134	360	14	play	play	VERB
asodahs-134	360	15	a	a	DET
asodahs-134	360	16	key	key	ADJ
asodahs-134	360	17	role	role	NOUN
asodahs-134	360	18	in	in	ADP
asodahs-134	360	19	restoring	restore	VERB
asodahs-134	360	20	no	no	DET
asodahs-134	360	21	bioavailability	bioavailability	NOUN
asodahs-134	360	22	in	in	ADP
asodahs-134	360	23	scd	scd	PROPN
asodahs-134	360	24	.	.	PUNCT
asodahs-134	361	1	regular	regular	ADJ
asodahs-134	361	2	physical	physical	ADJ
asodahs-134	361	3	activity	activity	NOUN
asodahs-134	361	4	has	have	AUX
asodahs-134	361	5	been	be	AUX
asodahs-134	361	6	shown	show	VERB
asodahs-134	361	7	to	to	PART
asodahs-134	361	8	increase	increase	VERB
asodahs-134	361	9	endothelial	endothelial	ADJ
asodahs-134	361	10	no	no	DET
asodahs-134	361	11	production	production	NOUN
asodahs-134	361	12	and	and	CCONJ
asodahs-134	361	13	improves	improve	VERB
asodahs-134	361	14	vascular	vascular	ADJ
asodahs-134	361	15	health	health	NOUN
asodahs-134	361	16	.	.	PUNCT
asodahs-134	362	1	exercise	exercise	NOUN
asodahs-134	362	2	stimulates	stimulate	NOUN
asodahs-134	362	3	enos	eno	NOUN
asodahs-134	362	4	activity	activity	NOUN
asodahs-134	362	5	,	,	PUNCT
asodahs-134	362	6	increases	increase	VERB
asodahs-134	362	7	blood	blood	NOUN
asodahs-134	362	8	flow	flow	NOUN
asodahs-134	362	9	,	,	PUNCT
asodahs-134	362	10	and	and	CCONJ
asodahs-134	362	11	helps	help	VERB
asodahs-134	362	12	maintain	maintain	VERB
asodahs-134	362	13	optimal	optimal	ADJ
asodahs-134	362	14	vascular	vascular	ADJ
asodahs-134	362	15	tone	tone	NOUN
asodahs-134	362	16	.	.	PUNCT
asodahs-134	363	1	moreover	moreover	ADV
asodahs-134	363	2	,	,	PUNCT
asodahs-134	363	3	maintaining	maintain	VERB
asodahs-134	363	4	a	a	DET
asodahs-134	363	5	healthy	healthy	ADJ
asodahs-134	363	6	diet	diet	NOUN
asodahs-134	363	7	rich	rich	ADJ
asodahs-134	363	8	in	in	ADP
asodahs-134	363	9	antioxidants	antioxidant	NOUN
asodahs-134	363	10	(	(	PUNCT
asodahs-134	363	11	such	such	ADJ
asodahs-134	363	12	as	as	ADP
asodahs-134	363	13	fruits	fruit	NOUN
asodahs-134	363	14	,	,	PUNCT
asodahs-134	363	15	vegetables	vegetable	NOUN
asodahs-134	363	16	,	,	PUNCT
asodahs-134	363	17	and	and	CCONJ
asodahs-134	363	18	whole	whole	ADJ
asodahs-134	363	19	grains	grain	NOUN
asodahs-134	363	20	)	)	PUNCT
asodahs-134	363	21	and	and	CCONJ
asodahs-134	363	22	omega-3	omega-3	NUM
asodahs-134	363	23	fatty	fatty	NOUN
asodahs-134	363	24	acids	acid	NOUN
asodahs-134	363	25	can	can	AUX
asodahs-134	363	26	help	help	VERB
asodahs-134	363	27	reduce	reduce	VERB
asodahs-134	363	28	oxidative	oxidative	ADJ
asodahs-134	363	29	stress	stress	NOUN
asodahs-134	363	30	and	and	CCONJ
asodahs-134	363	31	promote	promote	VERB
asodahs-134	363	32	no	no	DET
asodahs-134	363	33	production	production	NOUN
asodahs-134	363	34	.	.	PUNCT
asodahs-134	364	1	avoiding	avoid	VERB
asodahs-134	364	2	smoking	smoking	NOUN
asodahs-134	364	3	and	and	CCONJ
asodahs-134	364	4	managing	manage	VERB
asodahs-134	364	5	other	other	ADJ
asodahs-134	364	6	cardiovascular	cardiovascular	ADJ
asodahs-134	364	7	risk	risk	NOUN
asodahs-134	364	8	factors	factor	NOUN
asodahs-134	364	9	,	,	PUNCT
asodahs-134	364	10	such	such	ADJ
asodahs-134	364	11	as	as	ADP
asodahs-134	364	12	hypertension	hypertension	NOUN
asodahs-134	364	13	,	,	PUNCT
asodahs-134	364	14	can	can	AUX
asodahs-134	364	15	also	also	ADV
asodahs-134	364	16	improve	improve	VERB
asodahs-134	364	17	no	no	DET
asodahs-134	364	18	bioavailability	bioavailability	NOUN
asodahs-134	364	19	and	and	CCONJ
asodahs-134	364	20	reduce	reduce	VERB
asodahs-134	364	21	the	the	DET
asodahs-134	364	22	risk	risk	NOUN
asodahs-134	364	23	of	of	ADP
asodahs-134	364	24	vascular	vascular	ADJ
asodahs-134	364	25	complications	complication	NOUN
asodahs-134	364	26	in	in	ADP
asodahs-134	364	27	scd	scd	PROPN
asodahs-134	364	28	37	37	NUM
asodahs-134	364	29	.	.	PUNCT
asodahs-134	365	1	conclusion	conclusion	NOUN
asodahs-134	365	2	restoring	restore	VERB
asodahs-134	365	3	nitric	nitric	ADJ
asodahs-134	365	4	oxide	oxide	NOUN
asodahs-134	365	5	(	(	PUNCT
asodahs-134	365	6	no	no	NOUN
asodahs-134	365	7	)	)	PUNCT
asodahs-134	365	8	bioavailability	bioavailability	NOUN
asodahs-134	365	9	in	in	ADP
asodahs-134	365	10	sickle	sickle	NOUN
asodahs-134	365	11	cell	cell	NOUN
asodahs-134	365	12	disease	disease	NOUN
asodahs-134	365	13	(	(	PUNCT
asodahs-134	365	14	scd	scd	NOUN
asodahs-134	365	15	)	)	PUNCT
asodahs-134	365	16	represents	represent	VERB
asodahs-134	365	17	a	a	DET
asodahs-134	365	18	critical	critical	ADJ
asodahs-134	365	19	therapeutic	therapeutic	ADJ
asodahs-134	365	20	strategy	strategy	NOUN
asodahs-134	365	21	to	to	PART
asodahs-134	365	22	address	address	VERB
asodahs-134	365	23	the	the	DET
asodahs-134	365	24	vascular	vascular	ADJ
asodahs-134	365	25	dysfunction	dysfunction	NOUN
asodahs-134	365	26	and	and	CCONJ
asodahs-134	365	27	associated	associated	ADJ
asodahs-134	365	28	complications	complication	NOUN
asodahs-134	365	29	that	that	PRON
asodahs-134	365	30	significantly	significantly	ADV
asodahs-134	365	31	impact	impact	VERB
asodahs-134	365	32	patient	patient	ADJ
asodahs-134	365	33	quality	quality	NOUN
asodahs-134	365	34	of	of	ADP
asodahs-134	365	35	life	life	NOUN
asodahs-134	365	36	and	and	CCONJ
asodahs-134	365	37	longevity	longevity	NOUN
asodahs-134	365	38	.	.	PUNCT
asodahs-134	366	1	the	the	DET
asodahs-134	366	2	depletion	depletion	NOUN
asodahs-134	366	3	of	of	ADP
asodahs-134	366	4	no	no	PRON
asodahs-134	366	5	in	in	ADP
asodahs-134	366	6	scd	scd	PROPN
asodahs-134	366	7	is	be	AUX
asodahs-134	366	8	a	a	DET
asodahs-134	366	9	central	central	ADJ
asodahs-134	366	10	mechanism	mechanism	NOUN
asodahs-134	366	11	underlying	underlie	VERB
asodahs-134	366	12	endothelial	endothelial	ADJ
asodahs-134	366	13	dysfunction	dysfunction	NOUN
asodahs-134	366	14	,	,	PUNCT
asodahs-134	366	15	increased	increase	VERB
asodahs-134	366	16	vascular	vascular	ADJ
asodahs-134	366	17	tone	tone	NOUN
asodahs-134	366	18	,	,	PUNCT
asodahs-134	366	19	thrombosis	thrombosis	NOUN
asodahs-134	366	20	,	,	PUNCT
asodahs-134	366	21	and	and	CCONJ
asodahs-134	366	22	inflammation	inflammation	NOUN
asodahs-134	366	23	.	.	PUNCT
asodahs-134	367	1	these	these	DET
asodahs-134	367	2	pathophysiological	pathophysiological	ADJ
asodahs-134	367	3	processes	process	NOUN
asodahs-134	367	4	contribute	contribute	VERB
asodahs-134	367	5	to	to	ADP
asodahs-134	367	6	many	many	ADJ
asodahs-134	367	7	of	of	ADP
asodahs-134	367	8	the	the	DET
asodahs-134	367	9	hallmark	hallmark	ADJ
asodahs-134	367	10	complications	complication	NOUN
asodahs-134	367	11	of	of	ADP
asodahs-134	367	12	the	the	DET
asodahs-134	367	13	disease	disease	NOUN
asodahs-134	367	14	,	,	PUNCT
asodahs-134	367	15	including	include	VERB
asodahs-134	367	16	vaso	vaso	NOUN
asodahs-134	367	17	-	-	PUNCT
asodahs-134	367	18	occlusive	occlusive	ADJ
asodahs-134	367	19	crises	crisis	NOUN
asodahs-134	367	20	,	,	PUNCT
asodahs-134	367	21	pulmonary	pulmonary	ADJ
asodahs-134	367	22	hypertension	hypertension	NOUN
asodahs-134	367	23	,	,	PUNCT
asodahs-134	367	24	stroke	stroke	NOUN
asodahs-134	367	25	,	,	PUNCT
asodahs-134	367	26	and	and	CCONJ
asodahs-134	367	27	organ	organ	NOUN
asodahs-134	367	28	damage	damage	NOUN
asodahs-134	367	29	.	.	PUNCT
asodahs-134	368	1	therapeutic	therapeutic	ADJ
asodahs-134	368	2	interventions	intervention	NOUN
asodahs-134	368	3	aimed	aim	VERB
asodahs-134	368	4	at	at	ADP
asodahs-134	368	5	enhancing	enhance	VERB
asodahs-134	368	6	no	no	DET
asodahs-134	368	7	bioavailability	bioavailability	NOUN
asodahs-134	368	8	,	,	PUNCT
asodahs-134	368	9	such	such	ADJ
asodahs-134	368	10	as	as	ADP
asodahs-134	368	11	l	l	NOUN
asodahs-134	368	12	-	-	PUNCT
asodahs-134	368	13	arginine	arginine	NOUN
asodahs-134	368	14	supplementation	supplementation	NOUN
asodahs-134	368	15	,	,	PUNCT
asodahs-134	368	16	nitrate	nitrate	NOUN
asodahs-134	368	17	therapy	therapy	NOUN
asodahs-134	368	18	,	,	PUNCT
asodahs-134	368	19	antioxidant	antioxidant	ADJ
asodahs-134	368	20	treatment	treatment	NOUN
asodahs-134	368	21	,	,	PUNCT
asodahs-134	368	22	hydroxyurea	hydroxyurea	ADJ
asodahs-134	368	23	,	,	PUNCT
asodahs-134	368	24	and	and	CCONJ
asodahs-134	368	25	pde5	pde5	NOUN
asodahs-134	368	26	inhibitors	inhibitor	NOUN
asodahs-134	368	27	,	,	PUNCT
asodahs-134	368	28	show	show	VERB
asodahs-134	368	29	promise	promise	NOUN
asodahs-134	368	30	in	in	ADP
asodahs-134	368	31	improving	improve	VERB
asodahs-134	368	32	vascular	vascular	ADJ
asodahs-134	368	33	health	health	NOUN
asodahs-134	368	34	in	in	ADP
asodahs-134	368	35	scd	scd	PROPN
asodahs-134	368	36	patients	patient	NOUN
asodahs-134	368	37	.	.	PUNCT
asodahs-134	369	1	additionally	additionally	ADV
asodahs-134	369	2	,	,	PUNCT
asodahs-134	369	3	emerging	emerge	VERB
asodahs-134	369	4	gene	gene	NOUN
asodahs-134	369	5	therapies	therapy	NOUN
asodahs-134	369	6	and	and	CCONJ
asodahs-134	369	7	stem	stem	VERB
asodahs-134	369	8	cellbased	cellbase	VERB
asodahs-134	369	9	approaches	approach	NOUN
asodahs-134	369	10	offer	offer	VERB
asodahs-134	369	11	the	the	DET
asodahs-134	369	12	potential	potential	NOUN
asodahs-134	369	13	for	for	ADP
asodahs-134	369	14	long	long	ADJ
asodahs-134	369	15	-	-	PUNCT
asodahs-134	369	16	term	term	NOUN
asodahs-134	369	17	improvements	improvement	NOUN
asodahs-134	369	18	by	by	ADP
asodahs-134	369	19	targeting	target	VERB
asodahs-134	369	20	the	the	DET
asodahs-134	369	21	root	root	NOUN
asodahs-134	369	22	causes	cause	NOUN
asodahs-134	369	23	of	of	ADP
asodahs-134	369	24	no	no	DET
asodahs-134	369	25	depletion	depletion	NOUN
asodahs-134	369	26	,	,	PUNCT
asodahs-134	369	27	such	such	ADJ
asodahs-134	369	28	as	as	ADP
asodahs-134	369	29	hemolysis	hemolysis	NOUN
asodahs-134	369	30	and	and	CCONJ
asodahs-134	369	31	oxidative	oxidative	ADJ
asodahs-134	369	32	stress	stress	NOUN
asodahs-134	369	33	.	.	PUNCT
asodahs-134	370	1	while	while	SCONJ
asodahs-134	370	2	these	these	DET
asodahs-134	370	3	therapies	therapy	NOUN
asodahs-134	370	4	are	be	AUX
asodahs-134	370	5	promising	promise	VERB
asodahs-134	370	6	,	,	PUNCT
asodahs-134	370	7	they	they	PRON
asodahs-134	370	8	require	require	VERB
asodahs-134	370	9	careful	careful	ADJ
asodahs-134	370	10	clinical	clinical	ADJ
asodahs-134	370	11	evaluation	evaluation	NOUN
asodahs-134	370	12	to	to	PART
asodahs-134	370	13	ensure	ensure	VERB
asodahs-134	370	14	efficacy	efficacy	NOUN
asodahs-134	370	15	and	and	CCONJ
asodahs-134	370	16	safety	safety	NOUN
asodahs-134	370	17	in	in	ADP
asodahs-134	370	18	diverse	diverse	ADJ
asodahs-134	370	19	patient	patient	ADJ
asodahs-134	370	20	populations	population	NOUN
asodahs-134	370	21	.	.	PUNCT
asodahs-134	371	1	conflict	conflict	NOUN
asodahs-134	371	2	of	of	ADP
asodahs-134	371	3	interest	interest	NOUN
asodahs-134	371	4	:	:	PUNCT
asodahs-134	371	5	author	author	NOUN
asodahs-134	371	6	declares	declare	VERB
asodahs-134	371	7	no	no	DET
asodahs-134	371	8	potential	potential	ADJ
asodahs-134	371	9	conflict	conflict	NOUN
asodahs-134	371	10	of	of	ADP
asodahs-134	371	11	interest	interest	NOUN
asodahs-134	371	12	with	with	ADP
asodahs-134	371	13	respect	respect	NOUN
asodahs-134	371	14	to	to	ADP
asodahs-134	371	15	the	the	DET
asodahs-134	371	16	contents	content	NOUN
asodahs-134	371	17	,	,	PUNCT
asodahs-134	371	18	authorship	authorship	NOUN
asodahs-134	371	19	,	,	PUNCT
asodahs-134	371	20	and/or	and/or	CCONJ
asodahs-134	371	21	publication	publication	NOUN
asodahs-134	371	22	of	of	ADP
asodahs-134	371	23	this	this	DET
asodahs-134	371	24	article	article	NOUN
asodahs-134	371	25	.	.	PUNCT
asodahs-134	372	1	source	source	NOUN
asodahs-134	372	2	of	of	ADP
asodahs-134	372	3	support	support	NOUN
asodahs-134	372	4	:	:	PUNCT
asodahs-134	372	5	nil	nil	NOUN
asodahs-134	372	6	funding	funding	NOUN
asodahs-134	372	7	:	:	PUNCT
asodahs-134	372	8	the	the	DET
asodahs-134	372	9	authors	author	NOUN
asodahs-134	372	10	declared	declare	VERB
asodahs-134	372	11	that	that	SCONJ
asodahs-134	372	12	this	this	DET
asodahs-134	372	13	study	study	NOUN
asodahs-134	372	14	has	have	AUX
asodahs-134	372	15	received	receive	VERB
asodahs-134	372	16	no	no	DET
asodahs-134	372	17	financial	financial	ADJ
asodahs-134	372	18	support	support	NOUN
asodahs-134	372	19	.	.	PUNCT
asodahs-134	373	1	informed	informed	ADJ
asodahs-134	373	2	consent	consent	NOUN
asodahs-134	373	3	statement	statement	NOUN
asodahs-134	373	4	:	:	PUNCT
asodahs-134	373	5	not	not	PART
asodahs-134	373	6	applicable	applicable	ADJ
asodahs-134	373	7	.	.	PUNCT
asodahs-134	374	1	data	datum	NOUN
asodahs-134	374	2	availability	availability	NOUN
asodahs-134	374	3	statement	statement	NOUN
asodahs-134	374	4	:	:	PUNCT
asodahs-134	374	5	the	the	DET
asodahs-134	374	6	data	datum	NOUN
asodahs-134	374	7	supporting	support	VERB
asodahs-134	374	8	in	in	ADP
asodahs-134	374	9	this	this	DET
asodahs-134	374	10	paper	paper	NOUN
asodahs-134	374	11	are	be	AUX
asodahs-134	374	12	available	available	ADJ
asodahs-134	374	13	in	in	ADP
asodahs-134	374	14	the	the	DET
asodahs-134	374	15	cited	cite	VERB
asodahs-134	374	16	references	reference	NOUN
asodahs-134	374	17	.	.	PUNCT
asodahs-134	375	1	ethics	ethic	NOUN
asodahs-134	375	2	approval	approval	NOUN
asodahs-134	375	3	:	:	PUNCT
asodahs-134	375	4	not	not	PART
asodahs-134	375	5	applicable	applicable	ADJ
asodahs-134	375	6	.	.	PUNCT
asodahs-134	376	1	references	reference	NOUN
asodahs-134	376	2	1	1	NUM
asodahs-134	376	3	.	.	PUNCT
asodahs-134	377	1	gupta	gupta	PROPN
asodahs-134	377	2	a.	a.	PROPN
asodahs-134	377	3	sickle	sickle	PROPN
asodahs-134	377	4	cell	cell	NOUN
asodahs-134	377	5	anemia	anemia	NOUN
asodahs-134	377	6	and	and	CCONJ
asodahs-134	377	7	related	related	ADJ
asodahs-134	377	8	hemoglobinopathies	hemoglobinopathy	NOUN
asodahs-134	377	9	.	.	PUNCT
asodahs-134	378	1	indecision	indecision	NOUN
asodahs-134	378	2	making	make	VERB
asodahs-134	378	3	through	through	ADP
asodahs-134	378	4	problem	problem	NOUN
asodahs-134	378	5	based	base	VERB
asodahs-134	378	6	learning	learn	VERB
asodahs-134	378	7	in	in	ADP
asodahs-134	378	8	hematology	hematology	NOUN
asodahs-134	378	9	:	:	PUNCT
asodahs-134	378	10	a	a	DET
asodahs-134	378	11	step	step	NOUN
asodahs-134	378	12	-	-	PUNCT
asodahs-134	378	13	by	by	ADP
asodahs-134	378	14	-	-	PUNCT
asodahs-134	378	15	step	step	NOUN
asodahs-134	378	16	approach	approach	NOUN
asodahs-134	378	17	in	in	ADP
asodahs-134	378	18	patients	patient	NOUN
asodahs-134	378	19	with	with	ADP
asodahs-134	378	20	anemia	anemia	NOUN
asodahs-134	378	21	2024	2024	NUM
asodahs-134	378	22	:	:	PUNCT
asodahs-134	378	23	269	269	NUM
asodahs-134	378	24	-	-	SYM
asodahs-134	378	25	289	289	NUM
asodahs-134	378	26	.	.	PUNCT
asodahs-134	379	1	singapore	singapore	PROPN
asodahs-134	379	2	:	:	PUNCT
asodahs-134	379	3	springer	springer	NOUN
asodahs-134	379	4	nature	nature	PROPN
asodahs-134	379	5	singapore	singapore	PROPN
asodahs-134	379	6	.	.	PUNCT
asodahs-134	380	1	https://doi.org/10.1007/978-981-99-8933-1_21	https://doi.org/10.1007/978-981-99-8933-1_21	X
asodahs-134	380	2	https://doi.org/10.1007/978-981-99-8933-1_21	https://doi.org/10.1007/978-981-99-8933-1_21	PROPN
asodahs-134	381	1	emmanuel	emmanuel	PROPN
asodahs-134	381	2	ifeanyi	ifeanyi	PROPN
asodahs-134	381	3	obeagu	obeagu	PROPN
asodahs-134	381	4	asian	asian	PROPN
asodahs-134	381	5	journal	journal	PROPN
asodahs-134	381	6	of	of	ADP
asodahs-134	381	7	dental	dental	ADJ
asodahs-134	381	8	and	and	CCONJ
asodahs-134	381	9	health	health	NOUN
asodahs-134	381	10	sciences	science	NOUN
asodahs-134	381	11	.	.	PUNCT
asodahs-134	382	1	2025	2025	NUM
asodahs-134	382	2	;	;	PUNCT
asodahs-134	382	3	5(3):6	5(3):6	NUM
asodahs-134	382	4	-	-	SYM
asodahs-134	382	5	12	12	NUM
asodahs-134	383	1	[	[	X
asodahs-134	383	2	11	11	NUM
asodahs-134	383	3	]	]	PUNCT
asodahs-134	383	4	ajdhs.com	ajdhs.com	X
asodahs-134	383	5	2	2	NUM
asodahs-134	383	6	.	.	PUNCT
asodahs-134	383	7	hassan	hassan	PROPN
asodahs-134	383	8	ms	ms	PROPN
asodahs-134	383	9	,	,	PUNCT
asodahs-134	383	10	nasrin	nasrin	PROPN
asodahs-134	383	11	t	t	PROPN
asodahs-134	383	12	,	,	PUNCT
asodahs-134	383	13	mahalka	mahalka	VERB
asodahs-134	383	14	a	a	PRON
asodahs-134	383	15	,	,	PUNCT
asodahs-134	383	16	hoque	hoque	NOUN
asodahs-134	383	17	m	m	PROPN
asodahs-134	383	18	,	,	PUNCT
asodahs-134	383	19	ali	ali	PROPN
asodahs-134	383	20	s.	s.	PROPN
asodahs-134	383	21	a	a	DET
asodahs-134	383	22	perspective	perspective	NOUN
asodahs-134	383	23	on	on	ADP
asodahs-134	383	24	the	the	DET
asodahs-134	383	25	genesis	genesis	NOUN
asodahs-134	383	26	,	,	PUNCT
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asodahs-134	383	28	,	,	PUNCT
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asodahs-134	383	33	cell	cell	NOUN
asodahs-134	383	34	disease	disease	NOUN
asodahs-134	383	35	.	.	PUNCT
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asodahs-134	384	2	journal	journal	PROPN
asodahs-134	384	3	of	of	ADP
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asodahs-134	384	5	human	human	ADJ
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asodahs-134	384	7	.	.	PUNCT
asodahs-134	385	1	2024	2024	NUM
asodahs-134	385	2	;	;	PUNCT
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asodahs-134	385	4	.	.	PUNCT
asodahs-134	386	1	https://doi.org/10.1186/s43042-024-00623-1	https://doi.org/10.1186/s43042-024-00623-1	NUM
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asodahs-134	386	3	.	.	PUNCT
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asodahs-134	387	3	,	,	PUNCT
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asodahs-134	387	5	m	m	PROPN
asodahs-134	387	6	,	,	PUNCT
asodahs-134	387	7	talele	talele	PROPN
asodahs-134	387	8	c	c	X
asodahs-134	387	9	,	,	PUNCT
asodahs-134	387	10	sajan	sajan	PROPN
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asodahs-134	387	12	,	,	PUNCT
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asodahs-134	387	14	v	v	NOUN
asodahs-134	387	15	,	,	PUNCT
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asodahs-134	387	20	of	of	ADP
asodahs-134	387	21	sickle	sickle	NOUN
asodahs-134	387	22	cell	cell	NOUN
asodahs-134	387	23	disease	disease	NOUN
asodahs-134	387	24	:	:	PUNCT
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asodahs-134	387	26	impact	impact	NOUN
asodahs-134	387	27	,	,	PUNCT
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asodahs-134	387	29	strategies	strategy	NOUN
asodahs-134	387	30	,	,	PUNCT
asodahs-134	387	31	and	and	CCONJ
asodahs-134	387	32	future	future	ADJ
asodahs-134	387	33	directions	direction	NOUN
asodahs-134	387	34	.	.	PUNCT
asodahs-134	388	1	journal	journal	NOUN
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asodahs-134	388	5	.	.	PUNCT
asodahs-134	389	1	2024	2024	NUM
asodahs-134	389	2	;	;	PUNCT
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asodahs-134	389	4	)	)	PUNCT
asodahs-134	389	5	.	.	PUNCT
asodahs-134	390	1	https://doi.org/10.53555/jaz.v45i1.3390	https://doi.org/10.53555/jaz.v45i1.3390	PROPN
asodahs-134	390	2	4	4	X
asodahs-134	390	3	.	.	PUNCT
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asodahs-134	390	14	in	in	ADP
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asodahs-134	390	16	cell	cell	NOUN
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asodahs-134	390	18	:	:	PUNCT
asodahs-134	390	19	a	a	DET
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asodahs-134	390	22	.	.	PUNCT
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asodahs-134	391	2	.	.	PUNCT
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asodahs-134	392	3	.	.	PUNCT
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asodahs-134	393	2	.	.	PROPN
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asodahs-134	393	4	.	.	PUNCT
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asodahs-134	394	2	.	.	PUNCT
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asodahs-134	395	2	.	.	PUNCT
asodahs-134	396	1	2024;11(8):38	2024;11(8):38	NUM
asodahs-134	396	2	-	-	SYM
asodahs-134	396	3	46	46	NUM
asodahs-134	396	4	.	.	PUNCT
asodahs-134	397	1	https://doi.org/10.23880/hij16000247	https://doi.org/10.23880/hij16000247	PROPN
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asodahs-134	397	3	.	.	PUNCT
asodahs-134	397	4	obeagu	obeagu	PROPN
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asodahs-134	397	6	.	.	PUNCT
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asodahs-134	398	9	:	:	PUNCT
asodahs-134	398	10	a	a	DET
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asodahs-134	398	12	.	.	PUNCT
asodahs-134	399	1	int	int	NOUN
asodahs-134	399	2	.	.	PUNCT
asodahs-134	400	1	j.	j.	PROPN
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asodahs-134	400	3	.	.	PUNCT
asodahs-134	401	1	res	res	PROPN
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asodahs-134	401	4	.	.	PUNCT
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asodahs-134	402	2	.	.	PUNCT
asodahs-134	403	1	sci	sci	PROPN
asodahs-134	403	2	.	.	PUNCT
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asodahs-134	404	2	-	-	SYM
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asodahs-134	404	6	.	.	X
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asodahs-134	404	18	.	.	PUNCT
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asodahs-134	405	2	in	in	ADP
asodahs-134	405	3	the	the	DET
asodahs-134	405	4	management	management	NOUN
asodahs-134	405	5	of	of	ADP
asodahs-134	405	6	sickle	sickle	PROPN
asodahs-134	405	7	cell	cell	NOUN
asodahs-134	405	8	anaemia	anaemia	NOUN
asodahs-134	405	9	:	:	PUNCT
asodahs-134	405	10	an	an	DET
asodahs-134	405	11	area	area	NOUN
asodahs-134	405	12	to	to	PART
asodahs-134	405	13	be	be	AUX
asodahs-134	405	14	exploited	exploit	VERB
asodahs-134	405	15	for	for	ADP
asodahs-134	405	16	the	the	DET
asodahs-134	405	17	wellbeing	wellbeing	NOUN
asodahs-134	405	18	of	of	ADP
asodahs-134	405	19	the	the	DET
asodahs-134	405	20	patients	patient	NOUN
asodahs-134	405	21	.	.	PUNCT
asodahs-134	406	1	int	int	NOUN
asodahs-134	406	2	res	re	NOUN
asodahs-134	406	3	med	med	PROPN
asodahs-134	406	4	health	health	PROPN
asodahs-134	406	5	sci	sci	PROPN
asodahs-134	406	6	.	.	PROPN
asodahs-134	406	7	2023	2023	NUM
asodahs-134	406	8	sep	sep	NOUN
asodahs-134	406	9	11;6:12	11;6:12	NUM
asodahs-134	406	10	-	-	SYM
asodahs-134	406	11	7	7	NUM
asodahs-134	406	12	.	.	NOUN
asodahs-134	406	13	7	7	NUM
asodahs-134	406	14	.	.	PUNCT
asodahs-134	406	15	xiao	xiao	PROPN
asodahs-134	406	16	r	r	PROPN
asodahs-134	406	17	,	,	PUNCT
asodahs-134	406	18	li	li	PROPN
asodahs-134	406	19	l	l	PROPN
asodahs-134	406	20	,	,	PUNCT
asodahs-134	406	21	zhang	zhang	PROPN
asodahs-134	406	22	y	y	PROPN
asodahs-134	406	23	,	,	PUNCT
asodahs-134	406	24	fang	fang	PROPN
asodahs-134	406	25	l	l	PROPN
asodahs-134	406	26	,	,	PUNCT
asodahs-134	406	27	li	li	PROPN
asodahs-134	406	28	r	r	PROPN
asodahs-134	406	29	,	,	PUNCT
asodahs-134	406	30	song	song	NOUN
asodahs-134	406	31	d	d	PROPN
asodahs-134	406	32	,	,	PUNCT
asodahs-134	406	33	liang	liang	PROPN
asodahs-134	406	34	t	t	PROPN
asodahs-134	406	35	,	,	PUNCT
asodahs-134	406	36	su	su	PROPN
asodahs-134	406	37	x.	x.	NOUN
asodahs-134	406	38	reducing	reduce	VERB
asodahs-134	406	39	carbon	carbon	NOUN
asodahs-134	406	40	and	and	CCONJ
asodahs-134	406	41	nitrogen	nitrogen	NOUN
asodahs-134	406	42	loss	loss	NOUN
asodahs-134	406	43	by	by	ADP
asodahs-134	406	44	shortening	shorten	VERB
asodahs-134	406	45	the	the	DET
asodahs-134	406	46	composting	compost	VERB
asodahs-134	406	47	duration	duration	NOUN
asodahs-134	406	48	based	base	VERB
asodahs-134	406	49	on	on	ADP
asodahs-134	406	50	seed	seed	NOUN
asodahs-134	406	51	germination	germination	NOUN
asodahs-134	406	52	index	index	NOUN
asodahs-134	406	53	(	(	PUNCT
asodahs-134	406	54	scd@	scd@	PROPN
asodahs-134	406	55	gi	gi	PROPN
asodahs-134	406	56	):	):	PUNCT
asodahs-134	406	57	feasibilities	feasibility	NOUN
asodahs-134	406	58	and	and	CCONJ
asodahs-134	406	59	challenges	challenge	NOUN
asodahs-134	406	60	.	.	PUNCT
asodahs-134	407	1	science	science	NOUN
asodahs-134	407	2	of	of	ADP
asodahs-134	407	3	the	the	DET
asodahs-134	407	4	total	total	ADJ
asodahs-134	407	5	environment	environment	NOUN
asodahs-134	407	6	.	.	PUNCT
asodahs-134	408	1	2024:172883	2024:172883	NUM
asodahs-134	408	2	.	.	PUNCT
asodahs-134	409	1	https://doi.org/10.1016/j.scitotenv.2024.172883	https://doi.org/10.1016/j.scitotenv.2024.172883	NOUN
asodahs-134	409	2	pmid:38697528	pmid:38697528	NOUN
asodahs-134	409	3	8	8	NUM
asodahs-134	409	4	.	.	PUNCT
asodahs-134	410	1	lin	lin	PROPN
asodahs-134	410	2	w	w	PROPN
asodahs-134	410	3	,	,	PUNCT
asodahs-134	410	4	lv	lv	PROPN
asodahs-134	410	5	x	x	PROPN
asodahs-134	410	6	,	,	PUNCT
asodahs-134	410	7	wang	wang	PROPN
asodahs-134	410	8	q	q	PROPN
asodahs-134	410	9	,	,	PUNCT
asodahs-134	410	10	li	li	PROPN
asodahs-134	410	11	l	l	PROPN
asodahs-134	410	12	,	,	PUNCT
asodahs-134	410	13	zou	zou	PROPN
asodahs-134	410	14	g.	g.	PROPN
asodahs-134	410	15	nitrogen	nitrogen	PROPN
asodahs-134	410	16	concentration	concentration	NOUN
asodahs-134	410	17	dependent	dependent	ADJ
asodahs-134	410	18	optical	optical	ADJ
asodahs-134	410	19	defects	defect	NOUN
asodahs-134	410	20	transition	transition	NOUN
asodahs-134	410	21	in	in	ADP
asodahs-134	410	22	single	single	ADJ
asodahs-134	410	23	crystal	crystal	NOUN
asodahs-134	410	24	diamond	diamond	NOUN
asodahs-134	410	25	through	through	ADP
asodahs-134	410	26	low	low	ADJ
asodahs-134	410	27	pressure	pressure	NOUN
asodahs-134	410	28	high	high	ADJ
asodahs-134	410	29	temperature	temperature	NOUN
asodahs-134	410	30	annealing	annealing	NOUN
asodahs-134	410	31	.	.	PUNCT
asodahs-134	411	1	vacuum	vacuum	NOUN
asodahs-134	411	2	.	.	PUNCT
asodahs-134	412	1	2025:114329	2025:114329	X
asodahs-134	412	2	.	.	PUNCT
asodahs-134	413	1	https://doi.org/10.1016/j.vacuum.2025.114329	https://doi.org/10.1016/j.vacuum.2025.114329	ADJ
asodahs-134	413	2	9	9	NUM
asodahs-134	413	3	.	.	PUNCT
asodahs-134	413	4	wood	wood	NOUN
asodahs-134	413	5	kc	kc	PROPN
asodahs-134	413	6	,	,	PUNCT
asodahs-134	413	7	granger	granger	PROPN
asodahs-134	413	8	dn	dn	PROPN
asodahs-134	413	9	.	.	PROPN
asodahs-134	413	10	sickle	sickle	PROPN
asodahs-134	413	11	cell	cell	NOUN
asodahs-134	413	12	disease	disease	NOUN
asodahs-134	413	13	:	:	PUNCT
asodahs-134	413	14	role	role	NOUN
asodahs-134	413	15	of	of	ADP
asodahs-134	413	16	reactive	reactive	ADJ
asodahs-134	413	17	oxygen	oxygen	NOUN
asodahs-134	413	18	and	and	CCONJ
asodahs-134	413	19	nitrogen	nitrogen	NOUN
asodahs-134	413	20	metabolites	metabolite	NOUN
asodahs-134	413	21	.	.	PUNCT
asodahs-134	414	1	clinical	clinical	ADJ
asodahs-134	414	2	&	&	CCONJ
asodahs-134	414	3	experimental	experimental	ADJ
asodahs-134	414	4	pharmacology	pharmacology	NOUN
asodahs-134	414	5	&	&	CCONJ
asodahs-134	414	6	physiology	physiology	NOUN
asodahs-134	414	7	.	.	PUNCT
asodahs-134	415	1	2007	2007	NUM
asodahs-134	415	2	sep	sep	NOUN
asodahs-134	415	3	1;34(9	1;34(9	NOUN
asodahs-134	415	4	)	)	PUNCT
asodahs-134	415	5	.	.	PUNCT
asodahs-134	416	1	https://doi.org/10.1111/j.14401681.2007.04639.x	https://doi.org/10.1111/j.14401681.2007.04639.x	X
asodahs-134	416	2	pmid:17645642	pmid:17645642	VERB
asodahs-134	416	3	10	10	NUM
asodahs-134	416	4	.	.	PUNCT
asodahs-134	417	1	dijkmans	dijkmans	PROPN
asodahs-134	417	2	t	t	PROPN
asodahs-134	417	3	,	,	PUNCT
asodahs-134	417	4	djokic	djokic	PROPN
asodahs-134	417	5	mr	mr	PROPN
asodahs-134	417	6	,	,	PUNCT
asodahs-134	417	7	van	van	PROPN
asodahs-134	417	8	geem	geem	PROPN
asodahs-134	417	9	km	km	PROPN
asodahs-134	417	10	,	,	PUNCT
asodahs-134	417	11	marin	marin	NOUN
asodahs-134	417	12	gb	gb	PROPN
asodahs-134	417	13	.	.	PUNCT
asodahs-134	418	1	comprehensive	comprehensive	ADJ
asodahs-134	418	2	compositional	compositional	ADJ
asodahs-134	418	3	analysis	analysis	NOUN
asodahs-134	418	4	of	of	ADP
asodahs-134	418	5	sulfur	sulfur	NOUN
asodahs-134	418	6	and	and	CCONJ
asodahs-134	418	7	nitrogen	nitrogen	NOUN
asodahs-134	418	8	containing	contain	VERB
asodahs-134	418	9	compounds	compound	NOUN
asodahs-134	418	10	in	in	ADP
asodahs-134	418	11	shale	shale	NOUN
asodahs-134	418	12	oil	oil	NOUN
asodahs-134	418	13	using	use	VERB
asodahs-134	418	14	gc×	gc×	PROPN
asodahs-134	418	15	gc	gc	PROPN
asodahs-134	418	16	-	-	PUNCT
asodahs-134	418	17	fid	fid	NOUN
asodahs-134	418	18	/	/	SYM
asodahs-134	418	19	scd	scd	NOUN
asodahs-134	418	20	/	/	SYM
asodahs-134	418	21	ncd	ncd	PROPN
asodahs-134	418	22	/	/	SYM
asodahs-134	418	23	tof	tof	PROPN
asodahs-134	418	24	-	-	PUNCT
asodahs-134	418	25	ms	ms	PROPN
asodahs-134	418	26	.	.	PROPN
asodahs-134	418	27	fuel	fuel	NOUN
asodahs-134	418	28	.	.	PUNCT
asodahs-134	419	1	2015	2015	NUM
asodahs-134	419	2	;	;	PUNCT
asodahs-134	420	1	140:398	140:398	NUM
asodahs-134	420	2	-	-	PUNCT
asodahs-134	420	3	406	406	NUM
asodahs-134	420	4	.	.	PUNCT
asodahs-134	421	1	https://doi.org/10.1016/j.fuel.2014.09.055	https://doi.org/10.1016/j.fuel.2014.09.055	VERB
asodahs-134	421	2	11	11	NUM
asodahs-134	421	3	.	.	PUNCT
asodahs-134	422	1	muehle	muehle	PROPN
asodahs-134	422	2	m	m	PROPN
asodahs-134	422	3	,	,	PUNCT
asodahs-134	422	4	asmussen	asmussen	PROPN
asodahs-134	422	5	j	j	PROPN
asodahs-134	422	6	,	,	PUNCT
asodahs-134	422	7	becker	becker	PROPN
asodahs-134	422	8	mf	mf	VERB
asodahs-134	422	9	,	,	PUNCT
asodahs-134	422	10	schuelke	schuelke	ADJ
asodahs-134	422	11	t.	t.	NOUN
asodahs-134	422	12	extending	extend	VERB
asodahs-134	422	13	microwave	microwave	NOUN
asodahs-134	422	14	plasma	plasma	NOUN
asodahs-134	422	15	assisted	assist	VERB
asodahs-134	422	16	cvd	cvd	PROPN
asodahs-134	422	17	scd	scd	PROPN
asodahs-134	422	18	growth	growth	NOUN
asodahs-134	422	19	to	to	ADP
asodahs-134	422	20	pressures	pressure	NOUN
asodahs-134	422	21	of	of	ADP
asodahs-134	422	22	400	400	NUM
asodahs-134	422	23	torr	torr	NOUN
asodahs-134	422	24	.	.	PUNCT
asodahs-134	423	1	diamond	diamond	PROPN
asodahs-134	423	2	and	and	CCONJ
asodahs-134	423	3	related	related	ADJ
asodahs-134	423	4	materials	material	NOUN
asodahs-134	423	5	.	.	PUNCT
asodahs-134	423	6	2017	2017	NUM
asodahs-134	423	7	;	;	PUNCT
asodahs-134	423	8	79:150	79:150	NUM
asodahs-134	423	9	-	-	SYM
asodahs-134	423	10	163	163	NUM
asodahs-134	423	11	.	.	PUNCT
asodahs-134	424	1	https://doi.org/10.1016/j.diamond.2017.09.013	https://doi.org/10.1016/j.diamond.2017.09.013	PROPN
asodahs-134	424	2	12	12	NUM
asodahs-134	424	3	.	.	PUNCT
asodahs-134	425	1	obeagu	obeagu	PROPN
asodahs-134	425	2	ei	ei	PROPN
asodahs-134	425	3	,	,	PUNCT
asodahs-134	425	4	obeagu	obeagu	PROPN
asodahs-134	425	5	gu	gu	PROPN
asodahs-134	425	6	.	.	PUNCT
asodahs-134	425	7	immunization	immunization	NOUN
asodahs-134	425	8	strategies	strategy	NOUN
asodahs-134	425	9	for	for	ADP
asodahs-134	425	10	individuals	individual	NOUN
asodahs-134	425	11	with	with	ADP
asodahs-134	425	12	sickle	sickle	NOUN
asodahs-134	425	13	cell	cell	NOUN
asodahs-134	425	14	anemia	anemia	NOUN
asodahs-134	425	15	:	:	PUNCT
asodahs-134	425	16	a	a	DET
asodahs-134	425	17	narrative	narrative	NOUN
asodahs-134	425	18	review	review	NOUN
asodahs-134	425	19	.	.	PUNCT
asodahs-134	426	1	medicine	medicine	NOUN
asodahs-134	426	2	.	.	PUNCT
asodahs-134	427	1	2024	2024	NUM
asodahs-134	427	2	;	;	PUNCT
asodahs-134	427	3	103(38):e39756	103(38):e39756	NUM
asodahs-134	427	4	.	.	PUNCT
asodahs-134	428	1	https://doi.org/10.1097/md.0000000000039756	https://doi.org/10.1097/md.0000000000039756	PROPN
asodahs-134	428	2	pmid:39312357	pmid:39312357	ADV
asodahs-134	428	3	pmcid	pmcid	NOUN
asodahs-134	428	4	:	:	PUNCT
asodahs-134	428	5	pmc11419550	pmc11419550	NOUN
asodahs-134	428	6	13	13	NUM
asodahs-134	428	7	.	.	PUNCT
asodahs-134	429	1	obeagu	obeagu	PROPN
asodahs-134	429	2	ei	ei	PROPN
asodahs-134	429	3	.	.	PUNCT
asodahs-134	429	4	strategies	strategy	NOUN
asodahs-134	429	5	for	for	ADP
asodahs-134	429	6	reducing	reduce	VERB
asodahs-134	429	7	child	child	NOUN
asodahs-134	429	8	mortality	mortality	NOUN
asodahs-134	429	9	due	due	ADP
asodahs-134	429	10	to	to	ADP
asodahs-134	429	11	sickle	sickle	VERB
asodahs-134	429	12	cell	cell	NOUN
asodahs-134	429	13	disease	disease	NOUN
asodahs-134	429	14	in	in	ADP
asodahs-134	429	15	uganda	uganda	PROPN
asodahs-134	429	16	:	:	PUNCT
asodahs-134	429	17	a	a	DET
asodahs-134	429	18	narrative	narrative	NOUN
asodahs-134	429	19	review	review	NOUN
asodahs-134	429	20	.	.	PUNCT
asodahs-134	430	1	annals	annal	NOUN
asodahs-134	430	2	of	of	ADP
asodahs-134	430	3	medicine	medicine	NOUN
asodahs-134	430	4	and	and	CCONJ
asodahs-134	430	5	surgery.:10	surgery.:10	NOUN
asodahs-134	430	6	-	-	PUNCT
asodahs-134	430	7	97	97	NUM
asodahs-134	430	8	.	.	PUNCT
asodahs-134	431	1	14	14	NUM
asodahs-134	431	2	.	.	PUNCT
asodahs-134	432	1	obeagu	obeagu	PROPN
asodahs-134	432	2	ei	ei	PROPN
asodahs-134	432	3	.	.	PROPN
asodahs-134	432	4	erythropoeitin	erythropoeitin	PROPN
asodahs-134	432	5	in	in	ADP
asodahs-134	432	6	sickle	sickle	NOUN
asodahs-134	432	7	cell	cell	NOUN
asodahs-134	432	8	anaemia	anaemia	NOUN
asodahs-134	432	9	:	:	PUNCT
asodahs-134	432	10	a	a	DET
asodahs-134	432	11	review	review	NOUN
asodahs-134	432	12	.	.	PUNCT
asodahs-134	433	1	international	international	ADJ
asodahs-134	433	2	journal	journal	PROPN
asodahs-134	433	3	of	of	ADP
asodahs-134	433	4	research	research	NOUN
asodahs-134	433	5	studies	study	NOUN
asodahs-134	433	6	in	in	ADP
asodahs-134	433	7	medical	medical	ADJ
asodahs-134	433	8	and	and	CCONJ
asodahs-134	433	9	health	health	NOUN
asodahs-134	433	10	sciences	science	NOUN
asodahs-134	433	11	.	.	PUNCT
asodahs-134	434	1	2020;5(2):22	2020;5(2):22	NUM
asodahs-134	434	2	-	-	SYM
asodahs-134	434	3	8	8	NUM
asodahs-134	434	4	.	.	PUNCT
asodahs-134	435	1	https://doi.org/10.22259/ijrsmhs.0502004	https://doi.org/10.22259/ijrsmhs.0502004	VERB
asodahs-134	435	2	15	15	NUM
asodahs-134	435	3	.	.	PUNCT
asodahs-134	436	1	obeagu	obeagu	PROPN
asodahs-134	436	2	ei	ei	PROPN
asodahs-134	436	3	,	,	PUNCT
asodahs-134	436	4	obeagu	obeagu	PROPN
asodahs-134	436	5	gu	gu	PROPN
asodahs-134	436	6	.	.	PROPN
asodahs-134	436	7	malnutrition	malnutrition	NOUN
asodahs-134	436	8	in	in	ADP
asodahs-134	436	9	sickle	sickle	PROPN
asodahs-134	436	10	cell	cell	NOUN
asodahs-134	436	11	anemia	anemia	NOUN
asodahs-134	436	12	:	:	PUNCT
asodahs-134	436	13	prevalence	prevalence	NOUN
asodahs-134	436	14	,	,	PUNCT
asodahs-134	436	15	impact	impact	NOUN
asodahs-134	436	16	,	,	PUNCT
asodahs-134	436	17	and	and	CCONJ
asodahs-134	436	18	interventions	intervention	NOUN
asodahs-134	436	19	:	:	PUNCT
asodahs-134	436	20	a	a	DET
asodahs-134	436	21	review	review	NOUN
asodahs-134	436	22	.	.	PUNCT
asodahs-134	437	1	medicine	medicine	NOUN
asodahs-134	437	2	.	.	PUNCT
asodahs-134	438	1	2024	2024	NUM
asodahs-134	438	2	may	may	AUX
asodahs-134	438	3	17;103(20):e38164	17;103(20):e38164	NUM
asodahs-134	438	4	.	.	PUNCT
asodahs-134	439	1	https://doi.org/10.1097/md.0000000000038164	https://doi.org/10.1097/md.0000000000038164	PUNCT
asodahs-134	439	2	pmid:38758879	pmid:38758879	ADJ
asodahs-134	439	3	pmcid	pmcid	NOUN
asodahs-134	439	4	:	:	PUNCT
asodahs-134	439	5	pmc11098235	pmc11098235	VERB
asodahs-134	439	6	16	16	NUM
asodahs-134	439	7	.	.	PUNCT
asodahs-134	440	1	quemada	quemada	PROPN
asodahs-134	440	2	m	m	PROPN
asodahs-134	440	3	,	,	PUNCT
asodahs-134	440	4	delgado	delgado	VERB
asodahs-134	440	5	a	a	PRON
asodahs-134	440	6	,	,	PUNCT
asodahs-134	440	7	mateos	mateos	PROPN
asodahs-134	440	8	l	l	PROPN
asodahs-134	440	9	,	,	PUNCT
asodahs-134	440	10	villalobos	villalobos	PROPN
asodahs-134	440	11	fj	fj	PROPN
asodahs-134	440	12	.	.	PUNCT
asodahs-134	441	1	nitrogen	nitrogen	PROPN
asodahs-134	441	2	fertilization	fertilization	NOUN
asodahs-134	441	3	i	i	PRON
asodahs-134	441	4	:	:	PUNCT
asodahs-134	441	5	the	the	DET
asodahs-134	441	6	nitrogen	nitrogen	NOUN
asodahs-134	441	7	balance	balance	NOUN
asodahs-134	441	8	.	.	PUNCT
asodahs-134	442	1	inprinciples	inprinciple	NOUN
asodahs-134	442	2	of	of	ADP
asodahs-134	442	3	agronomy	agronomy	NOUN
asodahs-134	442	4	for	for	ADP
asodahs-134	442	5	sustainable	sustainable	ADJ
asodahs-134	442	6	agriculture	agriculture	NOUN
asodahs-134	442	7	2024	2024	NUM
asodahs-134	442	8	:	:	PUNCT
asodahs-134	442	9	377	377	NUM
asodahs-134	442	10	-	-	SYM
asodahs-134	442	11	401	401	NUM
asodahs-134	442	12	.	.	PUNCT
asodahs-134	443	1	cham	cham	PROPN
asodahs-134	443	2	:	:	PUNCT
asodahs-134	443	3	springer	springer	NOUN
asodahs-134	443	4	international	international	ADJ
asodahs-134	443	5	publishing	publishing	NOUN
asodahs-134	443	6	.	.	PUNCT
asodahs-134	444	1	https://doi.org/10.1007/978-3-03169150-8_26	https://doi.org/10.1007/978-3-03169150-8_26	PROPN
asodahs-134	444	2	17	17	NUM
asodahs-134	444	3	.	.	PUNCT
asodahs-134	445	1	krug	krug	PROPN
asodahs-134	445	2	ec	ec	PROPN
asodahs-134	445	3	,	,	PUNCT
asodahs-134	445	4	winstanley	winstanley	PROPN
asodahs-134	445	5	d.	d.	PROPN
asodahs-134	445	6	the	the	DET
asodahs-134	445	7	need	need	NOUN
asodahs-134	445	8	for	for	ADP
asodahs-134	445	9	comprehensive	comprehensive	ADJ
asodahs-134	445	10	and	and	CCONJ
asodahs-134	445	11	consistent	consistent	ADJ
asodahs-134	445	12	treatment	treatment	NOUN
asodahs-134	445	13	of	of	ADP
asodahs-134	445	14	the	the	DET
asodahs-134	445	15	nitrogen	nitrogen	NOUN
asodahs-134	445	16	cycle	cycle	NOUN
asodahs-134	445	17	in	in	ADP
asodahs-134	445	18	nitrogen	nitrogen	NOUN
asodahs-134	445	19	cycling	cycling	NOUN
asodahs-134	445	20	and	and	CCONJ
asodahs-134	445	21	mass	mass	NOUN
asodahs-134	445	22	balance	balance	NOUN
asodahs-134	445	23	studies	study	NOUN
asodahs-134	445	24	:	:	PUNCT
asodahs-134	445	25	i.	i.	PROPN
asodahs-134	445	26	terrestrial	terrestrial	PROPN
asodahs-134	445	27	nitrogen	nitrogen	NOUN
asodahs-134	445	28	cycle	cycle	NOUN
asodahs-134	445	29	.	.	PUNCT
asodahs-134	446	1	science	science	NOUN
asodahs-134	446	2	of	of	ADP
asodahs-134	446	3	the	the	DET
asodahs-134	446	4	total	total	ADJ
asodahs-134	446	5	environment	environment	NOUN
asodahs-134	446	6	.	.	PUNCT
asodahs-134	447	1	2002	2002	NUM
asodahs-134	447	2	;	;	PUNCT
asodahs-134	447	3	293(1	293(1	NUM
asodahs-134	447	4	-	-	SYM
asodahs-134	447	5	3):1	3):1	NUM
asodahs-134	447	6	-	-	SYM
asodahs-134	447	7	29	29	NUM
asodahs-134	447	8	.	.	PUNCT
asodahs-134	448	1	https://doi.org/10.1016/s0048-9697(01)01133-0	https://doi.org/10.1016/s0048-9697(01)01133-0	PROPN
asodahs-134	448	2	pmid:12109464	pmid:12109464	ADP
asodahs-134	448	3	18	18	NUM
asodahs-134	448	4	.	.	PUNCT
asodahs-134	449	1	zhang	zhang	PROPN
asodahs-134	449	2	cc	cc	PROPN
asodahs-134	449	3	,	,	PUNCT
asodahs-134	449	4	zhou	zhou	PROPN
asodahs-134	449	5	cz	cz	PROPN
asodahs-134	449	6	,	,	PUNCT
asodahs-134	449	7	burnap	burnap	PROPN
asodahs-134	449	8	rl	rl	PROPN
asodahs-134	449	9	,	,	PUNCT
asodahs-134	449	10	peng	peng	PROPN
asodahs-134	449	11	l.	l.	PROPN
asodahs-134	449	12	carbon	carbon	PROPN
asodahs-134	449	13	/	/	SYM
asodahs-134	449	14	nitrogen	nitrogen	NOUN
asodahs-134	449	15	metabolic	metabolic	NOUN
asodahs-134	449	16	balance	balance	NOUN
asodahs-134	449	17	:	:	PUNCT
asodahs-134	449	18	lessons	lesson	NOUN
asodahs-134	449	19	from	from	ADP
asodahs-134	449	20	cyanobacteria	cyanobacteria	NOUN
asodahs-134	449	21	.	.	PUNCT
asodahs-134	450	1	trends	trend	NOUN
asodahs-134	450	2	in	in	ADP
asodahs-134	450	3	plant	plant	NOUN
asodahs-134	450	4	science	science	NOUN
asodahs-134	450	5	.	.	PUNCT
asodahs-134	451	1	2018	2018	NUM
asodahs-134	451	2	;	;	PUNCT
asodahs-134	451	3	23(12):1116	23(12):1116	NUM
asodahs-134	451	4	-	-	SYM
asodahs-134	451	5	1130	1130	NUM
asodahs-134	451	6	.	.	PUNCT
asodahs-134	452	1	https://doi.org/10.1016/j.tplants.2018.09.008	https://doi.org/10.1016/j.tplants.2018.09.008	NOUN
asodahs-134	452	2	pmid:30292707	pmid:30292707	VERB
asodahs-134	452	3	19	19	NUM
asodahs-134	452	4	.	.	PUNCT
asodahs-134	453	1	enwonwu	enwonwu	PROPN
asodahs-134	453	2	co	co	PROPN
asodahs-134	453	3	,	,	PUNCT
asodahs-134	453	4	xu	xu	PROPN
asodahs-134	453	5	xx	xx	PROPN
asodahs-134	453	6	,	,	PUNCT
asodahs-134	453	7	turner	turner	PROPN
asodahs-134	453	8	e.	e.	PROPN
asodahs-134	453	9	nitrogen	nitrogen	PROPN
asodahs-134	453	10	metabolism	metabolism	NOUN
asodahs-134	453	11	in	in	ADP
asodahs-134	453	12	sickle	sickle	NOUN
asodahs-134	453	13	cell	cell	NOUN
asodahs-134	453	14	anemia	anemia	NOUN
asodahs-134	453	15	:	:	PUNCT
asodahs-134	453	16	free	free	ADJ
asodahs-134	453	17	amino	amino	NOUN
asodahs-134	453	18	acids	acid	NOUN
asodahs-134	453	19	in	in	ADP
asodahs-134	453	20	plasma	plasma	NOUN
asodahs-134	453	21	and	and	CCONJ
asodahs-134	453	22	urine	urine	NOUN
asodahs-134	453	23	.	.	PUNCT
asodahs-134	454	1	the	the	DET
asodahs-134	454	2	american	american	PROPN
asodahs-134	454	3	journal	journal	PROPN
asodahs-134	454	4	of	of	ADP
asodahs-134	454	5	the	the	DET
asodahs-134	454	6	medical	medical	ADJ
asodahs-134	454	7	sciences	science	NOUN
asodahs-134	454	8	.	.	PUNCT
asodahs-134	454	9	1990	1990	NUM
asodahs-134	454	10	;	;	PUNCT
asodahs-134	454	11	300(6):366	300(6):366	NUM
asodahs-134	454	12	-	-	SYM
asodahs-134	454	13	371	371	NUM
asodahs-134	454	14	.	.	PUNCT
asodahs-134	454	15	https://doi.org/10.1097/00000441-199012000-00005	https://doi.org/10.1097/00000441-199012000-00005	VERB
asodahs-134	454	16	pmid:2264574	pmid:2264574	NOUN
asodahs-134	454	17	20	20	NUM
asodahs-134	454	18	.	.	PUNCT
asodahs-134	455	1	borel	borel	PROPN
asodahs-134	455	2	mj	mj	PROPN
asodahs-134	455	3	,	,	PUNCT
asodahs-134	455	4	buchowski	buchowski	PROPN
asodahs-134	455	5	ms	ms	PROPN
asodahs-134	455	6	,	,	PUNCT
asodahs-134	455	7	turner	turner	PROPN
asodahs-134	455	8	ea	ea	PROPN
asodahs-134	455	9	,	,	PUNCT
asodahs-134	455	10	peeler	peeler	NOUN
asodahs-134	455	11	bb	bb	PROPN
asodahs-134	455	12	,	,	PUNCT
asodahs-134	455	13	goldstein	goldstein	PROPN
asodahs-134	455	14	re	re	PROPN
asodahs-134	455	15	,	,	PUNCT
asodahs-134	455	16	flakoll	flakoll	VERB
asodahs-134	456	1	pj	pj	PROPN
asodahs-134	456	2	.	.	PUNCT
asodahs-134	456	3	alterations	alteration	NOUN
asodahs-134	456	4	in	in	ADP
asodahs-134	456	5	basal	basal	ADJ
asodahs-134	456	6	nutrient	nutrient	NOUN
asodahs-134	456	7	metabolism	metabolism	NOUN
asodahs-134	456	8	increase	increase	NOUN
asodahs-134	456	9	resting	rest	VERB
asodahs-134	456	10	energy	energy	NOUN
asodahs-134	456	11	expenditure	expenditure	NOUN
asodahs-134	456	12	in	in	ADP
asodahs-134	456	13	sickle	sickle	NOUN
asodahs-134	456	14	cell	cell	NOUN
asodahs-134	456	15	disease	disease	NOUN
asodahs-134	456	16	.	.	PUNCT
asodahs-134	457	1	american	american	PROPN
asodahs-134	457	2	journal	journal	PROPN
asodahs-134	457	3	of	of	ADP
asodahs-134	457	4	physiology	physiology	NOUN
asodahs-134	457	5	-	-	PUNCT
asodahs-134	457	6	endocrinology	endocrinology	NOUN
asodahs-134	457	7	and	and	CCONJ
asodahs-134	457	8	metabolism	metabolism	NOUN
asodahs-134	457	9	.	.	PUNCT
asodahs-134	458	1	1998	1998	NUM
asodahs-134	458	2	;	;	PUNCT
asodahs-134	459	1	274(2):e357364	274(2):e357364	NUM
asodahs-134	459	2	.	.	PUNCT
asodahs-134	460	1	https://doi.org/10.1152/ajpendo.1998.274.2.e357	https://doi.org/10.1152/ajpendo.1998.274.2.e357	PROPN
asodahs-134	460	2	pmid:9486169	pmid:9486169	PROPN
asodahs-134	460	3	21	21	NUM
asodahs-134	460	4	.	.	PUNCT
asodahs-134	461	1	jackson	jackson	PROPN
asodahs-134	461	2	aa	aa	PROPN
asodahs-134	461	3	.	.	PUNCT
asodahs-134	462	1	the	the	DET
asodahs-134	462	2	use	use	NOUN
asodahs-134	462	3	of	of	ADP
asodahs-134	462	4	stable	stable	ADJ
asodahs-134	462	5	isotopes	isotope	NOUN
asodahs-134	462	6	to	to	PART
asodahs-134	462	7	study	study	VERB
asodahs-134	462	8	nitrogen	nitrogen	NOUN
asodahs-134	462	9	metabolism	metabolism	NOUN
asodahs-134	462	10	in	in	ADP
asodahs-134	462	11	homozygous	homozygous	ADJ
asodahs-134	462	12	sickle	sickle	NOUN
asodahs-134	462	13	cell	cell	NOUN
asodahs-134	462	14	disease	disease	NOUN
asodahs-134	462	15	.	.	PUNCT
asodahs-134	463	1	ingenetic	ingenetic	ADJ
asodahs-134	463	2	factors	factor	NOUN
asodahs-134	463	3	in	in	ADP
asodahs-134	463	4	nutrition	nutrition	NOUN
asodahs-134	463	5	.	.	PUNCT
asodahs-134	464	1	1984	1984	NUM
asodahs-134	464	2	:	:	PUNCT
asodahs-134	464	3	297	297	NUM
asodahs-134	464	4	-	-	SYM
asodahs-134	464	5	315	315	NUM
asodahs-134	464	6	.	.	PUNCT
asodahs-134	465	1	academic	academic	ADJ
asodahs-134	465	2	press	press	NOUN
asodahs-134	465	3	,	,	PUNCT
asodahs-134	465	4	new	new	PROPN
asodahs-134	465	5	york	york	PROPN
asodahs-134	465	6	.	.	PUNCT
asodahs-134	466	1	https://doi.org/10.1016/b978-0-12-715950-8.50024-x	https://doi.org/10.1016/b978-0-12-715950-8.50024-x	ADP
asodahs-134	466	2	pmcid	pmcid	NOUN
asodahs-134	466	3	:	:	PUNCT
asodahs-134	466	4	pmc7131065	pmc7131065	PROPN
asodahs-134	466	5	22	22	NUM
asodahs-134	466	6	.	.	PUNCT
asodahs-134	467	1	schnog	schnog	PROPN
asodahs-134	467	2	jj	jj	PROPN
asodahs-134	467	3	,	,	PUNCT
asodahs-134	467	4	jager	jager	PROPN
asodahs-134	467	5	eh	eh	INTJ
asodahs-134	467	6	,	,	PUNCT
asodahs-134	467	7	van	van	PROPN
asodahs-134	467	8	der	der	PROPN
asodahs-134	467	9	dijs	dijs	PROPN
asodahs-134	467	10	fp	fp	PROPN
asodahs-134	467	11	,	,	PUNCT
asodahs-134	467	12	duits	duits	PROPN
asodahs-134	467	13	aj	aj	PROPN
asodahs-134	467	14	,	,	PUNCT
asodahs-134	467	15	moshage	moshage	NOUN
asodahs-134	467	16	h	h	NOUN
asodahs-134	467	17	,	,	PUNCT
asodahs-134	467	18	muskiet	muskiet	PROPN
asodahs-134	467	19	fd	fd	PROPN
asodahs-134	467	20	,	,	PUNCT
asodahs-134	467	21	muskiet	muskiet	PROPN
asodahs-134	467	22	fa	fa	PROPN
asodahs-134	467	23	.	.	PROPN
asodahs-134	467	24	evidence	evidence	NOUN
asodahs-134	467	25	for	for	ADP
asodahs-134	467	26	a	a	DET
asodahs-134	467	27	metabolic	metabolic	NOUN
asodahs-134	467	28	shift	shift	NOUN
asodahs-134	467	29	of	of	ADP
asodahs-134	467	30	arginine	arginine	NOUN
asodahs-134	467	31	metabolism	metabolism	NOUN
asodahs-134	467	32	in	in	ADP
asodahs-134	467	33	sickle	sickle	NOUN
asodahs-134	467	34	cell	cell	NOUN
asodahs-134	467	35	disease	disease	NOUN
asodahs-134	467	36	.	.	PUNCT
asodahs-134	468	1	annals	annal	NOUN
asodahs-134	468	2	of	of	ADP
asodahs-134	468	3	hematology	hematology	NOUN
asodahs-134	468	4	.	.	PUNCT
asodahs-134	469	1	2004	2004	NUM
asodahs-134	469	2	;	;	PUNCT
asodahs-134	469	3	83:371	83:371	NUM
asodahs-134	469	4	-	-	SYM
asodahs-134	469	5	375	375	NUM
asodahs-134	469	6	.	.	PUNCT
asodahs-134	470	1	https://doi.org/10.1007/s00277-004-0856-9	https://doi.org/10.1007/s00277-004-0856-9	NOUN
asodahs-134	470	2	pmid:15054669	pmid:15054669	NOUN
asodahs-134	470	3	23	23	NUM
asodahs-134	470	4	.	.	PUNCT
asodahs-134	471	1	darghouth	darghouth	PROPN
asodahs-134	471	2	d	d	PROPN
asodahs-134	471	3	,	,	PUNCT
asodahs-134	471	4	koehl	koehl	PROPN
asodahs-134	471	5	b	b	NOUN
asodahs-134	471	6	,	,	PUNCT
asodahs-134	471	7	madalinski	madalinski	NOUN
asodahs-134	471	8	g	g	PROPN
asodahs-134	471	9	,	,	PUNCT
asodahs-134	471	10	heilier	heilier	PROPN
asodahs-134	471	11	jf	jf	PROPN
asodahs-134	471	12	,	,	PUNCT
asodahs-134	471	13	bovee	bovee	NOUN
asodahs-134	471	14	p	p	PROPN
asodahs-134	471	15	,	,	PUNCT
asodahs-134	471	16	xu	xu	PROPN
asodahs-134	471	17	y	y	PROPN
asodahs-134	471	18	,	,	PUNCT
asodahs-134	471	19	olivier	olivier	PROPN
asodahs-134	471	20	mf	mf	PROPN
asodahs-134	471	21	,	,	PUNCT
asodahs-134	471	22	bartolucci	bartolucci	NOUN
asodahs-134	471	23	p	p	NOUN
asodahs-134	471	24	,	,	PUNCT
asodahs-134	471	25	benkerrou	benkerrou	PROPN
asodahs-134	471	26	m	m	PROPN
asodahs-134	471	27	,	,	PUNCT
asodahs-134	471	28	pissard	pissard	PROPN
asodahs-134	471	29	s	s	PROPN
asodahs-134	471	30	,	,	PUNCT
asodahs-134	471	31	colin	colin	PROPN
asodahs-134	471	32	y.	y.	PROPN
asodahs-134	471	33	pathophysiology	pathophysiology	PROPN
asodahs-134	471	34	of	of	ADP
asodahs-134	471	35	sickle	sickle	NOUN
asodahs-134	471	36	cell	cell	NOUN
asodahs-134	471	37	disease	disease	NOUN
asodahs-134	471	38	is	be	AUX
asodahs-134	471	39	mirrored	mirror	VERB
asodahs-134	471	40	by	by	ADP
asodahs-134	471	41	the	the	DET
asodahs-134	471	42	red	red	ADJ
asodahs-134	471	43	blood	blood	NOUN
asodahs-134	471	44	cell	cell	NOUN
asodahs-134	471	45	metabolome	metabolome	NOUN
asodahs-134	471	46	.	.	PUNCT
asodahs-134	472	1	blood	blood	NOUN
asodahs-134	472	2	,	,	PUNCT
asodahs-134	472	3	the	the	DET
asodahs-134	472	4	journal	journal	NOUN
asodahs-134	472	5	of	of	ADP
asodahs-134	472	6	the	the	DET
asodahs-134	472	7	american	american	ADJ
asodahs-134	472	8	society	society	NOUN
asodahs-134	472	9	of	of	ADP
asodahs-134	472	10	hematology	hematology	NOUN
asodahs-134	472	11	.	.	PUNCT
asodahs-134	473	1	2011	2011	NUM
asodahs-134	473	2	;	;	PUNCT
asodahs-134	473	3	117(6):e57	117(6):e57	NUM
asodahs-134	473	4	-	-	SYM
asodahs-134	473	5	66	66	NUM
asodahs-134	473	6	.	.	PUNCT
asodahs-134	474	1	https://doi.org/10.1182/blood-2010-07-299636	https://doi.org/10.1182/blood-2010-07-299636	PRON
asodahs-134	474	2	pmid:21135259	pmid:21135259	PRON
asodahs-134	474	3	24	24	NUM
asodahs-134	474	4	.	.	PUNCT
asodahs-134	475	1	morris	morris	PROPN
asodahs-134	475	2	cr	cr	PROPN
asodahs-134	475	3	,	,	PUNCT
asodahs-134	475	4	kato	kato	PROPN
asodahs-134	475	5	gj	gj	PROPN
asodahs-134	475	6	,	,	PUNCT
asodahs-134	475	7	poljakovic	poljakovic	PROPN
asodahs-134	475	8	m	m	PROPN
asodahs-134	475	9	,	,	PUNCT
asodahs-134	475	10	wang	wang	PROPN
asodahs-134	475	11	x	x	PROPN
asodahs-134	475	12	,	,	PUNCT
asodahs-134	475	13	blackwelder	blackwelder	PROPN
asodahs-134	475	14	wc	wc	PROPN
asodahs-134	475	15	,	,	PUNCT
asodahs-134	475	16	sachdev	sachdev	PROPN
asodahs-134	475	17	v	v	PROPN
asodahs-134	475	18	,	,	PUNCT
asodahs-134	475	19	hazen	hazen	PROPN
asodahs-134	475	20	sl	sl	PROPN
asodahs-134	475	21	,	,	PUNCT
asodahs-134	475	22	vichinsky	vichinsky	ADJ
asodahs-134	475	23	ep	ep	PROPN
asodahs-134	475	24	,	,	PUNCT
asodahs-134	475	25	morris	morris	PROPN
asodahs-134	475	26	sm	sm	PROPN
asodahs-134	475	27	,	,	PUNCT
asodahs-134	475	28	gladwin	gladwin	PROPN
asodahs-134	475	29	mt	mt	PROPN
asodahs-134	475	30	.	.	PROPN
asodahs-134	475	31	dysregulated	dysregulate	VERB
asodahs-134	475	32	arginine	arginine	NOUN
asodahs-134	475	33	metabolism	metabolism	NOUN
asodahs-134	475	34	,	,	PUNCT
asodahs-134	475	35	hemolysis	hemolysis	NOUN
asodahs-134	475	36	-	-	PUNCT
asodahs-134	475	37	associated	associate	VERB
asodahs-134	475	38	pulmonary	pulmonary	ADJ
asodahs-134	475	39	hypertension	hypertension	NOUN
asodahs-134	475	40	,	,	PUNCT
asodahs-134	475	41	and	and	CCONJ
asodahs-134	475	42	mortality	mortality	NOUN
asodahs-134	475	43	in	in	ADP
asodahs-134	475	44	sickle	sickle	NOUN
asodahs-134	475	45	cell	cell	NOUN
asodahs-134	475	46	disease	disease	NOUN
asodahs-134	475	47	.	.	PUNCT
asodahs-134	476	1	jama	jama	PROPN
asodahs-134	476	2	.	.	PUNCT
asodahs-134	477	1	2005	2005	NUM
asodahs-134	477	2	;	;	PUNCT
asodahs-134	477	3	294(1):81	294(1):81	NUM
asodahs-134	477	4	-	-	SYM
asodahs-134	477	5	90	90	NUM
asodahs-134	477	6	.	.	PUNCT
asodahs-134	478	1	https://doi.org/10.1001/jama.294.1.81	https://doi.org/10.1001/jama.294.1.81	NOUN
asodahs-134	478	2	pmid:15998894	pmid:15998894	ADJ
asodahs-134	478	3	pmcid	pmcid	NOUN
asodahs-134	478	4	:	:	PUNCT
asodahs-134	478	5	pmc2065861	pmc2065861	NOUN
asodahs-134	478	6	25	25	NUM
asodahs-134	478	7	.	.	PUNCT
asodahs-134	479	1	zhou	zhou	PROPN
asodahs-134	479	2	y	y	PROPN
asodahs-134	479	3	,	,	PUNCT
asodahs-134	479	4	yu	yu	PROPN
asodahs-134	479	5	x	x	NOUN
asodahs-134	479	6	,	,	PUNCT
asodahs-134	479	7	nicely	nicely	ADV
asodahs-134	479	8	a	a	PRON
asodahs-134	479	9	,	,	PUNCT
asodahs-134	479	10	cunningham	cunningham	PROPN
asodahs-134	479	11	g	g	PROPN
asodahs-134	479	12	,	,	PUNCT
asodahs-134	479	13	challa	challa	PROPN
asodahs-134	479	14	c	c	PROPN
asodahs-134	479	15	,	,	PUNCT
asodahs-134	479	16	mckinley	mckinley	PROPN
asodahs-134	479	17	k	k	PROPN
asodahs-134	479	18	,	,	PUNCT
asodahs-134	479	19	nickel	nickel	NOUN
asodahs-134	479	20	r	r	NOUN
asodahs-134	479	21	,	,	PUNCT
asodahs-134	479	22	campbell	campbell	PROPN
asodahs-134	479	23	a	a	PROPN
asodahs-134	479	24	,	,	PUNCT
asodahs-134	479	25	darbari	darbari	PROPN
asodahs-134	479	26	d	d	NOUN
asodahs-134	479	27	,	,	PUNCT
asodahs-134	479	28	summar	summar	PROPN
asodahs-134	479	29	m	m	PROPN
asodahs-134	479	30	,	,	PUNCT
asodahs-134	479	31	majumdar	majumdar	PROPN
asodahs-134	479	32	s.	s.	PROPN
asodahs-134	479	33	amino	amino	PROPN
asodahs-134	479	34	acid	acid	PROPN
asodahs-134	479	35	signature	signature	NOUN
asodahs-134	479	36	during	during	ADP
asodahs-134	479	37	sickle	sickle	PROPN
asodahs-134	479	38	cell	cell	NOUN
asodahs-134	479	39	pain	pain	NOUN
asodahs-134	479	40	crisis	crisis	NOUN
asodahs-134	479	41	shows	show	VERB
asodahs-134	479	42	significant	significant	ADJ
asodahs-134	479	43	alterations	alteration	NOUN
asodahs-134	479	44	related	relate	VERB
asodahs-134	479	45	to	to	ADP
asodahs-134	479	46	nitric	nitric	ADJ
asodahs-134	479	47	oxide	oxide	NOUN
asodahs-134	479	48	and	and	CCONJ
asodahs-134	479	49	energy	energy	NOUN
asodahs-134	479	50	metabolism	metabolism	NOUN
asodahs-134	479	51	.	.	PUNCT
asodahs-134	480	1	molecular	molecular	ADJ
asodahs-134	480	2	genetics	genetic	NOUN
asodahs-134	480	3	and	and	CCONJ
asodahs-134	480	4	metabolism	metabolism	NOUN
asodahs-134	480	5	.	.	PUNCT
asodahs-134	481	1	2022	2022	NUM
asodahs-134	481	2	;	;	PUNCT
asodahs-134	481	3	137(1	137(1	NUM
asodahs-134	481	4	-	-	PUNCT
asodahs-134	481	5	2):146	2):146	PROPN
asodahs-134	481	6	-	-	PUNCT
asodahs-134	481	7	152	152	NUM
asodahs-134	481	8	.	.	PUNCT
asodahs-134	482	1	https://doi.org/10.1016/j.ymgme.2022.08.004	https://doi.org/10.1016/j.ymgme.2022.08.004	PROPN
asodahs-134	482	2	pmid:36030599	pmid:36030599	VERB
asodahs-134	482	3	26	26	NUM
asodahs-134	482	4	.	.	PUNCT
asodahs-134	483	1	d'alessandro	d'alessandro	PROPN
asodahs-134	483	2	a	a	PRON
asodahs-134	483	3	,	,	PUNCT
asodahs-134	483	4	nouraie	nouraie	PROPN
asodahs-134	483	5	sm	sm	PROPN
asodahs-134	483	6	,	,	PUNCT
asodahs-134	483	7	zhang	zhang	PROPN
asodahs-134	483	8	y	y	PROPN
asodahs-134	483	9	,	,	PUNCT
asodahs-134	483	10	cendali	cendali	PROPN
asodahs-134	483	11	f	f	PROPN
asodahs-134	483	12	,	,	PUNCT
asodahs-134	483	13	gamboni	gamboni	PROPN
asodahs-134	483	14	f	f	NOUN
asodahs-134	483	15	,	,	PUNCT
asodahs-134	483	16	reisz	reisz	ADJ
asodahs-134	483	17	ja	ja	PROPN
asodahs-134	483	18	,	,	PUNCT
asodahs-134	483	19	zhang	zhang	PROPN
asodahs-134	484	1	x	x	PROPN
asodahs-134	484	2	,	,	PUNCT
asodahs-134	484	3	bartsch	bartsch	X
asodahs-134	484	4	kw	kw	PROPN
asodahs-134	484	5	,	,	PUNCT
asodahs-134	484	6	galbraith	galbraith	PROPN
asodahs-134	484	7	md	md	PROPN
asodahs-134	484	8	,	,	PUNCT
asodahs-134	484	9	espinosa	espinosa	PROPN
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asodahs-134	484	11	,	,	PUNCT
asodahs-134	484	12	gordeuk	gordeuk	PROPN
asodahs-134	484	13	vr	vr	PROPN
asodahs-134	484	14	.	.	PROPN
asodahs-134	484	15	metabolic	metabolic	NOUN
asodahs-134	484	16	signatures	signature	NOUN
asodahs-134	484	17	of	of	ADP
asodahs-134	484	18	cardiorenal	cardiorenal	ADJ
asodahs-134	484	19	dysfunction	dysfunction	NOUN
asodahs-134	484	20	in	in	ADP
asodahs-134	484	21	plasma	plasma	NOUN
asodahs-134	484	22	from	from	ADP
asodahs-134	484	23	sickle	sickle	NOUN
asodahs-134	484	24	cell	cell	NOUN
asodahs-134	484	25	patients	patient	NOUN
asodahs-134	484	26	as	as	ADP
asodahs-134	484	27	a	a	DET
asodahs-134	484	28	function	function	NOUN
asodahs-134	484	29	of	of	ADP
asodahs-134	484	30	therapeutic	therapeutic	ADJ
asodahs-134	484	31	transfusion	transfusion	NOUN
asodahs-134	484	32	and	and	CCONJ
asodahs-134	484	33	hydroxyurea	hydroxyurea	ADJ
asodahs-134	484	34	treatment	treatment	NOUN
asodahs-134	484	35	.	.	PUNCT
asodahs-134	485	1	haematologica	haematologica	PROPN
asodahs-134	485	2	.	.	PUNCT
asodahs-134	486	1	2023	2023	NUM
asodahs-134	486	2	;	;	PUNCT
asodahs-134	487	1	108(12):3418	108(12):3418	PROPN
asodahs-134	487	2	.	.	PUNCT
asodahs-134	488	1	https://doi.org/10.3324/haematol.2023.283288	https://doi.org/10.3324/haematol.2023.283288	PROPN
asodahs-134	488	2	pmid:37439373	pmid:37439373	VERB
asodahs-134	488	3	pmcid	pmcid	NOUN
asodahs-134	488	4	:	:	PUNCT
asodahs-134	488	5	pmc10690926	pmc10690926	NOUN
asodahs-134	488	6	27	27	NUM
asodahs-134	488	7	.	.	PUNCT
asodahs-134	489	1	obeagu	obeagu	PROPN
asodahs-134	489	2	ei	ei	PROPN
asodahs-134	489	3	,	,	PUNCT
asodahs-134	489	4	prajapati	prajapati	PROPN
asodahs-134	489	5	sk	sk	PROPN
asodahs-134	489	6	,	,	PUNCT
asodahs-134	489	7	maurya	maurya	PROPN
asodahs-134	489	8	sd	sd	PROPN
asodahs-134	489	9	,	,	PUNCT
asodahs-134	489	10	maternal	maternal	ADJ
asodahs-134	489	11	anemia	anemia	NOUN
asodahs-134	489	12	in	in	ADP
asodahs-134	489	13	the	the	DET
asodahs-134	489	14	context	context	NOUN
asodahs-134	489	15	of	of	ADP
asodahs-134	489	16	infectious	infectious	ADJ
asodahs-134	489	17	diseases	disease	NOUN
asodahs-134	489	18	during	during	ADP
asodahs-134	489	19	pregnancy	pregnancy	NOUN
asodahs-134	489	20	:	:	PUNCT
asodahs-134	489	21	a	a	DET
asodahs-134	489	22	review	review	NOUN
asodahs-134	489	23	,	,	PUNCT
asodahs-134	489	24	international	international	ADJ
asodahs-134	489	25	journal	journal	NOUN
asodahs-134	489	26	of	of	ADP
asodahs-134	489	27	medical	medical	ADJ
asodahs-134	489	28	sciences	sciences	PROPN
asodahs-134	489	29	and	and	CCONJ
asodahs-134	489	30	pharma	pharma	PROPN
asodahs-134	489	31	research	research	NOUN
asodahs-134	489	32	,	,	PUNCT
asodahs-134	489	33	2025;11(1):8	2025;11(1):8	NUM
asodahs-134	489	34	-	-	SYM
asodahs-134	489	35	13	13	NUM
asodahs-134	489	36	https://doi.org/10.22270/ijmspr.v11i1.134	https://doi.org/10.22270/ijmspr.v11i1.134	PROPN
asodahs-134	489	37	28	28	NUM
asodahs-134	489	38	.	.	PUNCT
asodahs-134	490	1	obeagu	obeagu	PROPN
asodahs-134	490	2	ei	ei	PROPN
asodahs-134	490	3	,	,	PUNCT
asodahs-134	490	4	chukwu	chukwu	NOUN
asodahs-134	490	5	ph	ph	VERB
asodahs-134	490	6	.	.	PROPN
asodahs-134	490	7	inclusive	inclusive	ADJ
asodahs-134	490	8	healthcare	healthcare	PROPN
asodahs-134	490	9	approaches	approach	NOUN
asodahs-134	490	10	for	for	ADP
asodahs-134	490	11	hivpositive	hivpositive	ADJ
asodahs-134	490	12	sickle	sickle	NOUN
asodahs-134	490	13	cell	cell	NOUN
asodahs-134	490	14	disease	disease	NOUN
asodahs-134	490	15	patients	patient	NOUN
asodahs-134	490	16	:	:	PUNCT
asodahs-134	490	17	a	a	DET
asodahs-134	490	18	review	review	NOUN
asodahs-134	490	19	.	.	PUNCT
asodahs-134	491	1	current	current	ADJ
asodahs-134	491	2	research	research	NOUN
asodahs-134	491	3	in	in	ADP
asodahs-134	491	4	biological	biological	ADJ
asodahs-134	491	5	sciences	science	NOUN
asodahs-134	491	6	.	.	PUNCT
asodahs-134	492	1	2025;1(1):01	2025;1(1):01	NUM
asodahs-134	492	2	-	-	SYM
asodahs-134	492	3	8	8	NUM
asodahs-134	492	4	.	.	NOUN
asodahs-134	492	5	29	29	NUM
asodahs-134	492	6	.	.	PUNCT
asodahs-134	493	1	obeagu	obeagu	PROPN
asodahs-134	493	2	ei	ei	PROPN
asodahs-134	493	3	,	,	PUNCT
asodahs-134	493	4	obeagu	obeagu	PROPN
asodahs-134	493	5	gu	gu	PROPN
asodahs-134	493	6	.	.	PUNCT
asodahs-134	493	7	managing	manage	VERB
asodahs-134	493	8	gastrointestinal	gastrointestinal	ADJ
asodahs-134	493	9	challenges	challenge	NOUN
asodahs-134	493	10	:	:	PUNCT
asodahs-134	493	11	diarrhea	diarrhea	NOUN
asodahs-134	493	12	in	in	ADP
asodahs-134	493	13	sickle	sickle	NOUN
asodahs-134	493	14	cell	cell	NOUN
asodahs-134	493	15	anemia	anemia	NOUN
asodahs-134	493	16	.	.	PUNCT
asodahs-134	494	1	medicine	medicine	NOUN
asodahs-134	494	2	.	.	PUNCT
asodahs-134	495	1	2024	2024	NUM
asodahs-134	495	2	;	;	PUNCT
asodahs-134	495	3	103(18):e38075	103(18):e38075	NUM
asodahs-134	495	4	.	.	PUNCT
asodahs-134	496	1	https://doi.org/10.1097/md.0000000000038075	https://doi.org/10.1097/md.0000000000038075	X
asodahs-134	496	2	pmid:38701274	pmid:38701274	ADJ
asodahs-134	496	3	pmcid	pmcid	NOUN
asodahs-134	496	4	:	:	PUNCT
asodahs-134	496	5	pmc11062666	pmc11062666	NOUN
asodahs-134	496	6	30	30	NUM
asodahs-134	496	7	.	.	PUNCT
asodahs-134	497	1	obeagu	obeagu	PROPN
asodahs-134	497	2	ei	ei	PROPN
asodahs-134	497	3	,	,	PUNCT
asodahs-134	497	4	obeagu	obeagu	PROPN
asodahs-134	497	5	gu	gu	PROPN
asodahs-134	497	6	.	.	PUNCT
asodahs-134	497	7	living	live	VERB
asodahs-134	497	8	with	with	ADP
asodahs-134	497	9	sickle	sickle	NOUN
asodahs-134	497	10	cell	cell	NOUN
asodahs-134	497	11	in	in	ADP
asodahs-134	497	12	uganda	uganda	PROPN
asodahs-134	497	13	:	:	PUNCT
asodahs-134	497	14	a	a	DET
asodahs-134	497	15	comprehensive	comprehensive	ADJ
asodahs-134	497	16	perspective	perspective	NOUN
asodahs-134	497	17	on	on	ADP
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asodahs-134	497	19	,	,	PUNCT
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asodahs-134	497	21	strategies	strategy	NOUN
asodahs-134	497	22	,	,	PUNCT
asodahs-134	497	23	and	and	CCONJ
asodahs-134	497	24	health	health	NOUN
asodahs-134	497	25	interventions	intervention	NOUN
asodahs-134	497	26	.	.	PUNCT
asodahs-134	498	1	medicine	medicine	NOUN
asodahs-134	498	2	.	.	PUNCT
asodahs-134	499	1	2024	2024	NUM
asodahs-134	499	2	dec	dec	PROPN
asodahs-134	499	3	20;103(51):e41062	20;103(51):e41062	NUM
asodahs-134	499	4	.	.	PUNCT
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asodahs-134	500	3	pmcid	pmcid	NOUN
asodahs-134	500	4	:	:	PUNCT
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asodahs-134	513	6	,	,	PUNCT
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asodahs-134	513	9	,	,	PUNCT
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asodahs-134	513	44	---	---	PUNCT
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asodahs-134	515	2	;	;	PUNCT
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asodahs-134	516	8	:	:	PUNCT
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asodahs-134	517	17	in	in	ADP
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asodahs-134	519	2	;	;	PUNCT
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asodahs-134	519	4	-	-	SYM
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asodahs-134	520	3	.	.	PUNCT
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asodahs-134	524	4	-	-	SYM
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asodahs-134	525	3	.	.	PUNCT
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asodahs-134	526	3	,	,	PUNCT
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