id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
aji-148	Li, Shen; Li, Biaoru	Optimizing Cancer Immunotherapy through Combination Therapies: Advances in Chemoimmunotherapy, Lymphodepletion, and Precision Medicine	2024	11	.pdf	application/pdf	5409	557	48	The main goals of LD are to (1) reduce endogenous lymphocytes to inhibit the engraftment of CAR-T infusions and support their long-term activity; (2) reduce tumor cells to avoid rapid exhaustion of CAR-Ts; and (3) prepare and reprogram the microenvironment and soluble factors to ensure optimal engraftment, homing, and long-term survival of CAR-T cells The cytotoxic drugs kill tumor cells and inhibit their proliferation through DNA damage, inhibiting DNA replication and arresting mitosis.	cache/aji-148.pdf	txt/aji-148.txt