id	sid	tid	token	lemma	pos
aji-174	1	1	_	_	PUNCT
aji-174	2	1	_	_	PUNCT
aji-174	3	1	_	_	PUNCT
aji-174	4	1	_	_	PUNCT
aji-174	5	1	_	_	PUNCT
aji-174	6	1	_	_	PUNCT
aji-174	7	1	_	_	PUNCT
aji-174	8	1	_	_	PUNCT
aji-174	9	1	_	_	PUNCT
aji-174	10	1	_	_	PUNCT
aji-174	11	1	_	_	PUNCT
aji-174	12	1	_	_	PUNCT
aji-174	13	1	_	_	PUNCT
aji-174	14	1	_	_	PUNCT
aji-174	15	1	_	_	PUNCT
aji-174	16	1	_	_	PUNCT
aji-174	17	1	_	_	PUNCT
aji-174	18	1	_	_	PUNCT
aji-174	19	1	_	_	PUNCT
aji-174	20	1	_	_	PUNCT
aji-174	21	1	_	_	PUNCT
aji-174	22	1	_	_	PUNCT
aji-174	23	1	_	_	PUNCT
aji-174	24	1	_	_	PUNCT
aji-174	25	1	_	_	PUNCT
aji-174	26	1	_	_	PUNCT
aji-174	27	1	_	_	PUNCT
aji-174	28	1	_	_	PUNCT
aji-174	29	1	_	_	PUNCT
aji-174	30	1	_	_	PUNCT
aji-174	31	1	_	_	PUNCT
aji-174	32	1	_	_	PUNCT
aji-174	33	1	_	_	PUNCT
aji-174	34	1	_	_	PUNCT
aji-174	35	1	_	_	PUNCT
aji-174	36	1	_	_	PUNCT
aji-174	37	1	_	_	PUNCT
aji-174	38	1	_	_	PUNCT
aji-174	39	1	_	_	PUNCT
aji-174	40	1	_	_	PUNCT
aji-174	41	1	_	_	PUNCT
aji-174	42	1	_	_	PUNCT
aji-174	43	1	_	_	PUNCT
aji-174	44	1	_	_	PUNCT
aji-174	45	1	_	_	PUNCT
aji-174	46	1	_	_	PUNCT
aji-174	47	1	_	_	PUNCT
aji-174	48	1	_	_	PUNCT
aji-174	49	1	_	_	PUNCT
aji-174	50	1	_	_	PUNCT
aji-174	51	1	_	_	PUNCT
aji-174	52	1	_	_	PUNCT
aji-174	53	1	_	_	PUNCT
aji-174	54	1	_	_	PUNCT
aji-174	55	1	_	_	PUNCT
aji-174	56	1	_	_	PUNCT
aji-174	57	1	_	_	PUNCT
aji-174	58	1	_	_	PUNCT
aji-174	59	1	_	_	PUNCT
aji-174	60	1	_	_	PUNCT
aji-174	61	1	_	_	PUNCT
aji-174	62	1	_	_	PUNCT
aji-174	63	1	_	_	PUNCT
aji-174	64	1	_	_	PUNCT
aji-174	65	1	_	_	PUNCT
aji-174	66	1	_	_	PUNCT
aji-174	67	1	_	_	PUNCT
aji-174	68	1	_	_	PUNCT
aji-174	69	1	_	_	PUNCT
aji-174	70	1	_	_	PUNCT
aji-174	71	1	_	_	PUNCT
aji-174	72	1	_	_	PUNCT
aji-174	73	1	_	_	PUNCT
aji-174	74	1	_	_	PUNCT
aji-174	75	1	_	_	PUNCT
aji-174	76	1	_	_	PUNCT
aji-174	77	1	_	_	PUNCT
aji-174	78	1	_	_	PUNCT
aji-174	79	1	_	_	PUNCT
aji-174	80	1	_	_	PUNCT
aji-174	81	1	_	_	PUNCT
aji-174	82	1	_	_	PUNCT
aji-174	83	1	_	_	PUNCT
aji-174	84	1	_	_	PUNCT
aji-174	85	1	_	_	PUNCT
aji-174	86	1	_	_	PUNCT
aji-174	87	1	_	_	PUNCT
aji-174	88	1	_	_	PUNCT
aji-174	89	1	_	_	PUNCT
aji-174	90	1	_	_	PUNCT
aji-174	91	1	_	_	PUNCT
aji-174	92	1	_	_	PUNCT
aji-174	93	1	_	_	PUNCT
aji-174	94	1	_	_	PUNCT
aji-174	95	1	_	_	PUNCT
aji-174	96	1	_	_	PUNCT
aji-174	97	1	_	_	PUNCT
aji-174	98	1	_	_	PUNCT
aji-174	99	1	_	_	PUNCT
aji-174	100	1	_	_	PUNCT
aji-174	101	1	_	_	PUNCT
aji-174	102	1	*	*	PUNCT
aji-174	102	2	corresponding	correspond	VERB
aji-174	102	3	author	author	NOUN
aji-174	102	4	:	:	PUNCT
aji-174	102	5	e	e	NOUN
aji-174	102	6	-	-	NOUN
aji-174	102	7	mail	mail	NOUN
aji-174	102	8	:	:	PUNCT
aji-174	102	9	ayodeleadeli101@gmail.com	ayodeleadeli101@gmail.com	NUM
aji-174	102	10	;	;	PUNCT
aji-174	102	11	cite	cite	VERB
aji-174	102	12	as	as	SCONJ
aji-174	102	13	:	:	PUNCT
aji-174	102	14	fagbemi	fagbemi	PROPN
aji-174	102	15	oluwaseyi	oluwaseyi	PROPN
aji-174	102	16	ajibola	ajibola	PROPN
aji-174	102	17	,	,	PUNCT
aji-174	102	18	and	and	CCONJ
aji-174	102	19	adedoyin	adedoyin	PROPN
aji-174	102	20	elizabeth	elizabeth	PROPN
aji-174	102	21	ayodele	ayodele	PROPN
aji-174	102	22	.	.	PUNCT
aji-174	103	1	2025	2025	NUM
aji-174	103	2	.	.	PUNCT
aji-174	104	1	“	"	PUNCT
aji-174	104	2	epigenetic	epigenetic	ADJ
aji-174	104	3	dysregulation	dysregulation	NOUN
aji-174	104	4	and	and	CCONJ
aji-174	104	5	its	its	PRON
aji-174	104	6	role	role	NOUN
aji-174	104	7	in	in	ADP
aji-174	104	8	immune	immune	NOUN
aji-174	104	9	-	-	PUNCT
aji-174	104	10	mediated	mediate	VERB
aji-174	104	11	diseases	disease	NOUN
aji-174	104	12	”	"	PUNCT
aji-174	104	13	.	.	PUNCT
aji-174	105	1	asian	asian	ADJ
aji-174	105	2	journal	journal	NOUN
aji-174	105	3	of	of	ADP
aji-174	105	4	immunology	immunology	NOUN
aji-174	105	5	8	8	NUM
aji-174	105	6	(	(	PUNCT
aji-174	105	7	1):230–241	1):230–241	NUM
aji-174	105	8	.	.	PUNCT
aji-174	106	1	https://doi.org/10.9734/aji/2025/v8i1174	https://doi.org/10.9734/aji/2025/v8i1174	PROPN
aji-174	106	2	.	.	PUNCT
aji-174	107	1	asian	asian	PROPN
aji-174	107	2	journal	journal	PROPN
aji-174	107	3	of	of	ADP
aji-174	107	4	immunology	immunology	NOUN
aji-174	107	5	volume	volume	NOUN
aji-174	107	6	8	8	NUM
aji-174	107	7	,	,	PUNCT
aji-174	107	8	issue	issue	NOUN
aji-174	107	9	1	1	NUM
aji-174	107	10	,	,	PUNCT
aji-174	107	11	page	page	NOUN
aji-174	107	12	230	230	NUM
aji-174	107	13	-	-	SYM
aji-174	107	14	241	241	NUM
aji-174	107	15	,	,	PUNCT
aji-174	107	16	2025	2025	NUM
aji-174	107	17	;	;	PUNCT
aji-174	107	18	article	article	NOUN
aji-174	107	19	no.aji.144830	no.aji.144830	NOUN
aji-174	107	20	epigenetic	epigenetic	ADJ
aji-174	107	21	dysregulation	dysregulation	NOUN
aji-174	107	22	and	and	CCONJ
aji-174	107	23	its	its	PRON
aji-174	107	24	role	role	NOUN
aji-174	107	25	in	in	ADP
aji-174	107	26	immune	immune	NOUN
aji-174	107	27	-	-	PUNCT
aji-174	107	28	mediated	mediate	VERB
aji-174	107	29	diseases	disease	NOUN
aji-174	107	30	fagbemi	fagbemi	PROPN
aji-174	107	31	oluwaseyi	oluwaseyi	VERB
aji-174	107	32	ajibola	ajibola	PROPN
aji-174	107	33	a	a	PRON
aji-174	107	34	and	and	CCONJ
aji-174	107	35	adedoyin	adedoyin	PROPN
aji-174	107	36	elizabeth	elizabeth	PROPN
aji-174	107	37	ayodele	ayodele	PROPN
aji-174	108	1	b	b	X
aji-174	108	2	*	*	PUNCT
aji-174	108	3	a	a	DET
aji-174	108	4	department	department	NOUN
aji-174	108	5	of	of	ADP
aji-174	108	6	human	human	PROPN
aji-174	108	7	anatomy	anatomy	PROPN
aji-174	108	8	,	,	PUNCT
aji-174	108	9	college	college	NOUN
aji-174	108	10	of	of	ADP
aji-174	108	11	medicine	medicine	NOUN
aji-174	108	12	and	and	CCONJ
aji-174	108	13	surgery	surgery	NOUN
aji-174	108	14	,	,	PUNCT
aji-174	108	15	federal	federal	ADJ
aji-174	108	16	university	university	NOUN
aji-174	108	17	lokoja	lokoja	PROPN
aji-174	108	18	,	,	PUNCT
aji-174	108	19	kogi	kogi	PROPN
aji-174	108	20	state	state	PROPN
aji-174	108	21	,	,	PUNCT
aji-174	108	22	nigeria	nigeria	PROPN
aji-174	108	23	.	.	PUNCT
aji-174	109	1	b	b	X
aji-174	109	2	department	department	NOUN
aji-174	109	3	of	of	ADP
aji-174	109	4	microbiology	microbiology	NOUN
aji-174	109	5	,	,	PUNCT
aji-174	109	6	federal	federal	ADJ
aji-174	109	7	university	university	PROPN
aji-174	109	8	oye	oye	PROPN
aji-174	109	9	ekiti	ekiti	PROPN
aji-174	109	10	,	,	PUNCT
aji-174	109	11	ekiti	ekiti	PROPN
aji-174	109	12	state	state	PROPN
aji-174	109	13	,	,	PUNCT
aji-174	109	14	nigeria	nigeria	PROPN
aji-174	109	15	.	.	PUNCT
aji-174	110	1	authors	author	NOUN
aji-174	110	2	’	'	PUNCT
aji-174	110	3	contributions	contribution	NOUN
aji-174	110	4	this	this	DET
aji-174	110	5	work	work	NOUN
aji-174	110	6	was	be	AUX
aji-174	110	7	carried	carry	VERB
aji-174	110	8	out	out	ADP
aji-174	110	9	in	in	ADP
aji-174	110	10	collaboration	collaboration	NOUN
aji-174	110	11	between	between	ADP
aji-174	110	12	both	both	DET
aji-174	110	13	authors	author	NOUN
aji-174	110	14	.	.	PUNCT
aji-174	111	1	both	both	DET
aji-174	111	2	authors	author	NOUN
aji-174	111	3	read	read	VERB
aji-174	111	4	and	and	CCONJ
aji-174	111	5	approved	approve	VERB
aji-174	111	6	the	the	DET
aji-174	111	7	final	final	ADJ
aji-174	111	8	manuscript	manuscript	NOUN
aji-174	111	9	.	.	PUNCT
aji-174	112	1	article	article	NOUN
aji-174	112	2	information	information	PROPN
aji-174	112	3	doi	doi	PROPN
aji-174	112	4	:	:	PUNCT
aji-174	112	5	https://doi.org/10.9734/aji/2025/v8i1174	https://doi.org/10.9734/aji/2025/v8i1174	PROPN
aji-174	112	6	open	open	ADJ
aji-174	112	7	peer	peer	NOUN
aji-174	112	8	review	review	NOUN
aji-174	112	9	history	history	NOUN
aji-174	112	10	:	:	PUNCT
aji-174	112	11	this	this	DET
aji-174	112	12	journal	journal	NOUN
aji-174	112	13	follows	follow	VERB
aji-174	112	14	the	the	DET
aji-174	112	15	advanced	advance	VERB
aji-174	112	16	open	open	ADJ
aji-174	112	17	peer	peer	NOUN
aji-174	112	18	review	review	NOUN
aji-174	112	19	policy	policy	NOUN
aji-174	112	20	.	.	PUNCT
aji-174	113	1	identity	identity	NOUN
aji-174	113	2	of	of	ADP
aji-174	113	3	the	the	DET
aji-174	113	4	reviewers	reviewer	NOUN
aji-174	113	5	,	,	PUNCT
aji-174	113	6	editor(s	editor(s	NOUN
aji-174	113	7	)	)	PUNCT
aji-174	113	8	and	and	CCONJ
aji-174	113	9	additional	additional	ADJ
aji-174	113	10	reviewers	reviewer	NOUN
aji-174	113	11	,	,	PUNCT
aji-174	113	12	peer	peer	NOUN
aji-174	113	13	review	review	NOUN
aji-174	113	14	comments	comment	NOUN
aji-174	113	15	,	,	PUNCT
aji-174	113	16	different	different	ADJ
aji-174	113	17	versions	version	NOUN
aji-174	113	18	of	of	ADP
aji-174	113	19	the	the	DET
aji-174	113	20	manuscript	manuscript	NOUN
aji-174	113	21	,	,	PUNCT
aji-174	113	22	comments	comment	NOUN
aji-174	113	23	of	of	ADP
aji-174	113	24	the	the	DET
aji-174	113	25	editors	editor	NOUN
aji-174	113	26	,	,	PUNCT
aji-174	113	27	etc	etc	X
aji-174	113	28	are	be	AUX
aji-174	113	29	available	available	ADJ
aji-174	113	30	here	here	ADV
aji-174	113	31	:	:	PUNCT
aji-174	113	32	https://pr.sdiarticle5.com/review-history/144830	https://pr.sdiarticle5.com/review-history/144830	PROPN
aji-174	113	33	received	receive	VERB
aji-174	113	34	:	:	PUNCT
aji-174	113	35	18/07/2025	18/07/2025	NUM
aji-174	113	36	published	publish	VERB
aji-174	113	37	:	:	PUNCT
aji-174	113	38	27/09/2025	27/09/2025	NUM
aji-174	113	39	abstract	abstract	ADJ
aji-174	113	40	immune	immune	NOUN
aji-174	113	41	-	-	PUNCT
aji-174	113	42	mediated	mediate	VERB
aji-174	113	43	diseases	disease	NOUN
aji-174	113	44	,	,	PUNCT
aji-174	113	45	including	include	VERB
aji-174	113	46	rheumatoid	rheumatoid	NOUN
aji-174	113	47	arthritis	arthritis	NOUN
aji-174	113	48	(	(	PUNCT
aji-174	113	49	ra	ra	NOUN
aji-174	113	50	)	)	PUNCT
aji-174	113	51	,	,	PUNCT
aji-174	113	52	systemic	systemic	ADJ
aji-174	113	53	lupus	lupus	PROPN
aji-174	113	54	erythematosus	erythematosus	NOUN
aji-174	113	55	(	(	PUNCT
aji-174	113	56	sle	sle	PROPN
aji-174	113	57	)	)	PUNCT
aji-174	113	58	,	,	PUNCT
aji-174	113	59	multiple	multiple	ADJ
aji-174	113	60	sclerosis	sclerosis	NOUN
aji-174	113	61	(	(	PUNCT
aji-174	113	62	ms	ms	NOUN
aji-174	113	63	)	)	PUNCT
aji-174	113	64	and	and	CCONJ
aji-174	113	65	inflammatory	inflammatory	ADJ
aji-174	113	66	bowel	bowel	NOUN
aji-174	113	67	disease	disease	NOUN
aji-174	113	68	(	(	PUNCT
aji-174	113	69	ibd	ibd	PROPN
aji-174	113	70	:	:	PUNCT
aji-174	113	71	crohn	crohn	PROPN
aji-174	113	72	's	's	PART
aji-174	113	73	disease	disease	NOUN
aji-174	113	74	&	&	CCONJ
aji-174	113	75	ulcerative	ulcerative	ADJ
aji-174	113	76	colitis	colitis	NOUN
aji-174	113	77	)	)	PUNCT
aji-174	113	78	represent	represent	VERB
aji-174	113	79	a	a	DET
aji-174	113	80	significant	significant	ADJ
aji-174	113	81	global	global	ADJ
aji-174	113	82	health	health	NOUN
aji-174	113	83	burden	burden	NOUN
aji-174	113	84	characterized	characterize	VERB
aji-174	113	85	by	by	ADP
aji-174	113	86	a	a	DET
aji-174	113	87	loss	loss	NOUN
aji-174	113	88	of	of	ADP
aji-174	113	89	immune	immune	ADJ
aji-174	113	90	tolerance	tolerance	NOUN
aji-174	113	91	and	and	CCONJ
aji-174	113	92	chronic	chronic	ADJ
aji-174	113	93	inflammation	inflammation	NOUN
aji-174	113	94	.	.	PUNCT
aji-174	114	1	while	while	SCONJ
aji-174	114	2	genetic	genetic	ADJ
aji-174	114	3	predisposition	predisposition	NOUN
aji-174	114	4	plays	play	VERB
aji-174	114	5	a	a	DET
aji-174	114	6	crucial	crucial	ADJ
aji-174	114	7	role	role	NOUN
aji-174	114	8	,	,	PUNCT
aji-174	114	9	it	it	PRON
aji-174	114	10	does	do	AUX
aji-174	114	11	not	not	PART
aji-174	114	12	fully	fully	ADV
aji-174	114	13	account	account	VERB
aji-174	114	14	for	for	ADP
aji-174	114	15	disease	disease	NOUN
aji-174	114	16	pathogenesis	pathogenesis	NOUN
aji-174	114	17	,	,	PUNCT
aji-174	114	18	onset	onset	VERB
aji-174	114	19	,	,	PUNCT
aji-174	114	20	or	or	CCONJ
aji-174	114	21	flare	flare	NOUN
aji-174	114	22	-	-	PUNCT
aji-174	114	23	ups	up	NOUN
aji-174	114	24	.	.	PUNCT
aji-174	115	1	the	the	DET
aji-174	115	2	emerging	emerge	VERB
aji-174	115	3	field	field	NOUN
aji-174	115	4	of	of	ADP
aji-174	115	5	epigenetics	epigenetic	NOUN
aji-174	115	6	provides	provide	VERB
aji-174	115	7	a	a	DET
aji-174	115	8	critical	critical	ADJ
aji-174	115	9	mechanistic	mechanistic	ADJ
aji-174	115	10	link	link	NOUN
aji-174	115	11	between	between	ADP
aji-174	115	12	genetic	genetic	ADJ
aji-174	115	13	susceptibility	susceptibility	NOUN
aji-174	115	14	and	and	CCONJ
aji-174	115	15	environmental	environmental	ADJ
aji-174	115	16	triggers	trigger	NOUN
aji-174	115	17	.	.	PUNCT
aji-174	116	1	this	this	DET
aji-174	116	2	review	review	NOUN
aji-174	116	3	synthesizes	synthesize	VERB
aji-174	116	4	current	current	ADJ
aji-174	116	5	evidence	evidence	NOUN
aji-174	116	6	on	on	ADP
aji-174	116	7	how	how	SCONJ
aji-174	116	8	dysregulation	dysregulation	NOUN
aji-174	116	9	of	of	ADP
aji-174	116	10	key	key	ADJ
aji-174	116	11	epigenetic	epigenetic	ADJ
aji-174	116	12	mechanisms	mechanism	NOUN
aji-174	116	13	,	,	PUNCT
aji-174	116	14	dna	dna	PROPN
aji-174	116	15	methylation	methylation	NOUN
aji-174	116	16	,	,	PUNCT
aji-174	116	17	histone	histone	NOUN
aji-174	116	18	modifications	modification	NOUN
aji-174	116	19	,	,	PUNCT
aji-174	116	20	and	and	CCONJ
aji-174	116	21	non	non	ADJ
aji-174	116	22	-	-	ADJ
aji-174	116	23	coding	coding	ADJ
aji-174	116	24	rna	rna	NOUN
aji-174	116	25	expression	expression	NOUN
aji-174	116	26	,	,	PUNCT
aji-174	116	27	contributes	contribute	VERB
aji-174	116	28	to	to	ADP
aji-174	116	29	the	the	DET
aji-174	116	30	breakdown	breakdown	NOUN
aji-174	116	31	of	of	ADP
aji-174	116	32	immune	immune	ADJ
aji-174	116	33	homeostasis	homeostasis	NOUN
aji-174	116	34	.	.	PUNCT
aji-174	117	1	we	we	PRON
aji-174	117	2	detail	detail	VERB
aji-174	117	3	the	the	DET
aji-174	117	4	aberrant	aberrant	ADJ
aji-174	117	5	epigenetic	epigenetic	ADJ
aji-174	117	6	landscapes	landscape	NOUN
aji-174	117	7	in	in	ADP
aji-174	117	8	specific	specific	ADJ
aji-174	117	9	immune	immune	ADJ
aji-174	117	10	cell	cell	NOUN
aji-174	117	11	subsets	subset	NOUN
aji-174	117	12	(	(	PUNCT
aji-174	117	13	e.g.	e.g.	ADV
aji-174	117	14	,	,	PUNCT
aji-174	117	15	t	t	NOUN
aji-174	117	16	cells	cell	NOUN
aji-174	117	17	,	,	PUNCT
aji-174	117	18	b	b	NOUN
aji-174	117	19	cells	cell	NOUN
aji-174	117	20	,	,	PUNCT
aji-174	117	21	macrophages	macrophage	NOUN
aji-174	117	22	)	)	PUNCT
aji-174	117	23	across	across	ADP
aji-174	117	24	major	major	ADJ
aji-174	117	25	autoimmune	autoimmune	ADJ
aji-174	117	26	disorders	disorder	NOUN
aji-174	117	27	.	.	PUNCT
aji-174	118	1	furthermore	furthermore	ADV
aji-174	118	2	,	,	PUNCT
aji-174	118	3	we	we	PRON
aji-174	118	4	explore	explore	VERB
aji-174	118	5	the	the	DET
aji-174	118	6	potential	potential	NOUN
aji-174	118	7	of	of	ADP
aji-174	118	8	epigenetic	epigenetic	ADJ
aji-174	118	9	modifications	modification	NOUN
aji-174	118	10	as	as	ADP
aji-174	118	11	novel	novel	ADJ
aji-174	118	12	biomarkers	biomarker	NOUN
aji-174	118	13	for	for	ADP
aji-174	118	14	diagnosis	diagnosis	NOUN
aji-174	118	15	,	,	PUNCT
aji-174	118	16	prognosis	prognosis	NOUN
aji-174	118	17	,	,	PUNCT
aji-174	118	18	and	and	CCONJ
aji-174	118	19	disease	disease	NOUN
aji-174	118	20	activity	activity	NOUN
aji-174	118	21	monitoring	monitoring	NOUN
aji-174	118	22	.	.	PUNCT
aji-174	119	1	finally	finally	ADV
aji-174	119	2	,	,	PUNCT
aji-174	119	3	we	we	PRON
aji-174	119	4	discuss	discuss	VERB
aji-174	119	5	the	the	DET
aji-174	119	6	promising	promising	ADJ
aji-174	119	7	therapeutic	therapeutic	ADJ
aji-174	119	8	avenue	avenue	NOUN
aji-174	119	9	of	of	ADP
aji-174	119	10	"	"	PUNCT
aji-174	119	11	epigenetic	epigenetic	ADJ
aji-174	119	12	therapy	therapy	NOUN
aji-174	119	13	,	,	PUNCT
aji-174	119	14	"	"	PUNCT
aji-174	119	15	review	review	NOUN
aji-174	119	16	article	article	NOUN
aji-174	119	17	https://doi.org/10.9734/aji/2025/v8i1174	https://doi.org/10.9734/aji/2025/v8i1174	PROPN
aji-174	119	18	https://pr.sdiarticle5.com/review-history/144830	https://pr.sdiarticle5.com/review-history/144830	PROPN
aji-174	119	19	ajibola	ajibola	PROPN
aji-174	119	20	and	and	CCONJ
aji-174	119	21	ayodele	ayodele	PROPN
aji-174	119	22	;	;	PUNCT
aji-174	119	23	asian	asian	PROPN
aji-174	119	24	j.	j.	PROPN
aji-174	119	25	immunol	immunol	PROPN
aji-174	119	26	.	.	PROPN
aji-174	119	27	,	,	PUNCT
aji-174	119	28	vol	vol	NOUN
aji-174	119	29	.	.	PROPN
aji-174	119	30	8	8	NUM
aji-174	119	31	,	,	PUNCT
aji-174	119	32	no	no	INTJ
aji-174	119	33	.	.	NOUN
aji-174	119	34	1	1	NUM
aji-174	119	35	,	,	PUNCT
aji-174	119	36	pp	pp	ADJ
aji-174	119	37	.	.	PUNCT
aji-174	120	1	230	230	NUM
aji-174	120	2	-	-	SYM
aji-174	120	3	241	241	NUM
aji-174	120	4	,	,	PUNCT
aji-174	120	5	2025	2025	NUM
aji-174	120	6	;	;	PUNCT
aji-174	120	7	article	article	NOUN
aji-174	120	8	no.aji.144830	no.aji.144830	PART
aji-174	120	9	231	231	NUM
aji-174	120	10	repurposing	repurpose	VERB
aji-174	120	11	existing	exist	VERB
aji-174	120	12	drugs	drug	NOUN
aji-174	120	13	and	and	CCONJ
aji-174	120	14	developing	develop	VERB
aji-174	120	15	new	new	ADJ
aji-174	120	16	compounds	compound	NOUN
aji-174	120	17	to	to	PART
aji-174	120	18	reverse	reverse	VERB
aji-174	120	19	pathogenic	pathogenic	ADJ
aji-174	120	20	epigenetic	epigenetic	ADJ
aji-174	120	21	marks	mark	NOUN
aji-174	120	22	and	and	CCONJ
aji-174	120	23	restore	restore	VERB
aji-174	120	24	immune	immune	ADJ
aji-174	120	25	tolerance	tolerance	NOUN
aji-174	120	26	.	.	PUNCT
aji-174	121	1	keywords	keyword	NOUN
aji-174	121	2	:	:	PUNCT
aji-174	121	3	epigenetics	epigenetic	NOUN
aji-174	121	4	;	;	PUNCT
aji-174	121	5	autoimmunity	autoimmunity	NOUN
aji-174	121	6	;	;	PUNCT
aji-174	121	7	dna	dna	NOUN
aji-174	121	8	methylation	methylation	NOUN
aji-174	121	9	;	;	PUNCT
aji-174	121	10	histone	histone	NOUN
aji-174	121	11	modification	modification	NOUN
aji-174	121	12	;	;	PUNCT
aji-174	121	13	non	non	ADJ
aji-174	121	14	-	-	ADJ
aji-174	121	15	coding	code	VERB
aji-174	121	16	rna	rna	NOUN
aji-174	121	17	;	;	PUNCT
aji-174	121	18	rheumatoid	rheumatoid	NOUN
aji-174	121	19	arthritis	arthritis	NOUN
aji-174	121	20	;	;	PUNCT
aji-174	121	21	systemic	systemic	ADJ
aji-174	121	22	lupus	lupus	PROPN
aji-174	121	23	erythematosus	erythematosus	NOUN
aji-174	121	24	;	;	PUNCT
aji-174	121	25	multiple	multiple	ADJ
aji-174	121	26	sclerosis	sclerosis	NOUN
aji-174	121	27	;	;	PUNCT
aji-174	121	28	biomarkers	biomarker	NOUN
aji-174	121	29	;	;	PUNCT
aji-174	121	30	epigenetic	epigenetic	ADJ
aji-174	121	31	therapy	therapy	NOUN
aji-174	121	32	.	.	PUNCT
aji-174	122	1	1	1	X
aji-174	122	2	.	.	X
aji-174	122	3	introduction	introduction	NOUN
aji-174	122	4	immune	immune	NOUN
aji-174	122	5	-	-	PUNCT
aji-174	122	6	mediated	mediate	VERB
aji-174	122	7	inflammatory	inflammatory	ADJ
aji-174	122	8	diseases	disease	NOUN
aji-174	122	9	(	(	PUNCT
aji-174	122	10	imids	imid	NOUN
aji-174	122	11	)	)	PUNCT
aji-174	122	12	,	,	PUNCT
aji-174	122	13	encompassing	encompass	VERB
aji-174	122	14	a	a	DET
aji-174	122	15	broad	broad	ADJ
aji-174	122	16	spectrum	spectrum	NOUN
aji-174	122	17	of	of	ADP
aji-174	122	18	conditions	condition	NOUN
aji-174	122	19	such	such	ADJ
aji-174	122	20	as	as	ADP
aji-174	122	21	rheumatoid	rheumatoid	NOUN
aji-174	122	22	arthritis	arthritis	NOUN
aji-174	122	23	(	(	PUNCT
aji-174	122	24	ra	ra	NOUN
aji-174	122	25	)	)	PUNCT
aji-174	122	26	,	,	PUNCT
aji-174	122	27	systemic	systemic	ADJ
aji-174	122	28	lupus	lupus	PROPN
aji-174	122	29	erythematosus	erythematosus	NOUN
aji-174	122	30	(	(	PUNCT
aji-174	122	31	sle	sle	PROPN
aji-174	122	32	)	)	PUNCT
aji-174	122	33	,	,	PUNCT
aji-174	122	34	multiple	multiple	ADJ
aji-174	122	35	sclerosis	sclerosis	NOUN
aji-174	122	36	(	(	PUNCT
aji-174	122	37	ms	ms	NOUN
aji-174	122	38	)	)	PUNCT
aji-174	122	39	,	,	PUNCT
aji-174	122	40	and	and	CCONJ
aji-174	122	41	inflammatory	inflammatory	ADJ
aji-174	122	42	bowel	bowel	NOUN
aji-174	122	43	disease	disease	NOUN
aji-174	122	44	(	(	PUNCT
aji-174	122	45	ibd	ibd	PROPN
aji-174	122	46	)	)	PUNCT
aji-174	122	47	,	,	PUNCT
aji-174	122	48	represent	represent	VERB
aji-174	122	49	a	a	DET
aji-174	122	50	formidable	formidable	ADJ
aji-174	122	51	challenge	challenge	NOUN
aji-174	122	52	to	to	ADP
aji-174	122	53	global	global	ADJ
aji-174	122	54	public	public	ADJ
aji-174	122	55	health	health	NOUN
aji-174	122	56	.	.	PUNCT
aji-174	123	1	these	these	DET
aji-174	123	2	chronic	chronic	NOUN
aji-174	123	3	,	,	PUNCT
aji-174	123	4	debilitating	debilitate	VERB
aji-174	123	5	disorders	disorder	NOUN
aji-174	123	6	are	be	AUX
aji-174	123	7	characterized	characterize	VERB
aji-174	123	8	by	by	ADP
aji-174	123	9	a	a	DET
aji-174	123	10	pathological	pathological	ADJ
aji-174	123	11	breakdown	breakdown	NOUN
aji-174	123	12	of	of	ADP
aji-174	123	13	self	self	NOUN
aji-174	123	14	-	-	PUNCT
aji-174	123	15	tolerance	tolerance	NOUN
aji-174	123	16	,	,	PUNCT
aji-174	123	17	leading	lead	VERB
aji-174	123	18	to	to	ADP
aji-174	123	19	uncontrolled	uncontrolled	ADJ
aji-174	123	20	immune	immune	ADJ
aji-174	123	21	activation	activation	NOUN
aji-174	123	22	against	against	ADP
aji-174	123	23	specific	specific	ADJ
aji-174	123	24	tissues	tissue	NOUN
aji-174	123	25	or	or	CCONJ
aji-174	123	26	systemically	systemically	ADV
aji-174	123	27	,	,	PUNCT
aji-174	123	28	resulting	result	VERB
aji-174	123	29	in	in	ADP
aji-174	123	30	persistent	persistent	ADJ
aji-174	123	31	inflammation	inflammation	NOUN
aji-174	123	32	and	and	CCONJ
aji-174	123	33	organ	organ	NOUN
aji-174	123	34	damage	damage	NOUN
aji-174	123	35	(	(	PUNCT
aji-174	123	36	wilkinson	wilkinson	PROPN
aji-174	123	37	&	&	CCONJ
aji-174	123	38	shapiro	shapiro	PROPN
aji-174	123	39	,	,	PUNCT
aji-174	123	40	2024	2024	NUM
aji-174	123	41	)	)	PUNCT
aji-174	123	42	.	.	PUNCT
aji-174	124	1	the	the	DET
aji-174	124	2	collective	collective	ADJ
aji-174	124	3	prevalence	prevalence	NOUN
aji-174	124	4	of	of	ADP
aji-174	124	5	imids	imid	NOUN
aji-174	124	6	is	be	AUX
aji-174	124	7	estimated	estimate	VERB
aji-174	124	8	to	to	PART
aji-174	124	9	affect	affect	VERB
aji-174	124	10	5	5	NUM
aji-174	124	11	-	-	SYM
aji-174	124	12	10	10	NUM
aji-174	124	13	%	%	NOUN
aji-174	124	14	of	of	ADP
aji-174	124	15	the	the	DET
aji-174	124	16	population	population	NOUN
aji-174	124	17	in	in	ADP
aji-174	124	18	developed	develop	VERB
aji-174	124	19	nations	nation	NOUN
aji-174	124	20	,	,	PUNCT
aji-174	124	21	posing	pose	VERB
aji-174	124	22	a	a	DET
aji-174	124	23	significant	significant	ADJ
aji-174	124	24	economic	economic	ADJ
aji-174	124	25	and	and	CCONJ
aji-174	124	26	social	social	ADJ
aji-174	124	27	burden	burden	NOUN
aji-174	124	28	due	due	ADP
aji-174	124	29	to	to	ADP
aji-174	124	30	long	long	ADJ
aji-174	124	31	-	-	PUNCT
aji-174	124	32	term	term	NOUN
aji-174	124	33	disability	disability	NOUN
aji-174	124	34	,	,	PUNCT
aji-174	124	35	reduced	reduce	VERB
aji-174	124	36	quality	quality	NOUN
aji-174	124	37	of	of	ADP
aji-174	124	38	life	life	NOUN
aji-174	124	39	,	,	PUNCT
aji-174	124	40	and	and	CCONJ
aji-174	124	41	the	the	DET
aji-174	124	42	need	need	NOUN
aji-174	124	43	for	for	ADP
aji-174	124	44	lifelong	lifelong	ADJ
aji-174	124	45	medical	medical	ADJ
aji-174	124	46	management	management	NOUN
aji-174	124	47	(	(	PUNCT
aji-174	124	48	stroeks	stroek	NOUN
aji-174	124	49	et	et	PROPN
aji-174	124	50	al	al	PROPN
aji-174	124	51	.	.	PROPN
aji-174	124	52	,	,	PUNCT
aji-174	124	53	2025	2025	NUM
aji-174	124	54	)	)	PUNCT
aji-174	124	55	the	the	DET
aji-174	124	56	etiological	etiological	ADJ
aji-174	124	57	landscape	landscape	NOUN
aji-174	124	58	of	of	ADP
aji-174	124	59	autoimmunity	autoimmunity	NOUN
aji-174	124	60	has	have	AUX
aji-174	124	61	long	long	ADV
aji-174	124	62	been	be	AUX
aji-174	124	63	conceptualized	conceptualize	VERB
aji-174	124	64	through	through	ADP
aji-174	124	65	the	the	DET
aji-174	124	66	lens	lens	NOUN
aji-174	124	67	of	of	ADP
aji-174	124	68	genetic	genetic	ADJ
aji-174	124	69	predisposition	predisposition	NOUN
aji-174	124	70	interacting	interact	VERB
aji-174	124	71	with	with	ADP
aji-174	124	72	environmental	environmental	ADJ
aji-174	124	73	triggers	trigger	NOUN
aji-174	124	74	.	.	PUNCT
aji-174	125	1	the	the	DET
aji-174	125	2	advent	advent	NOUN
aji-174	125	3	of	of	ADP
aji-174	125	4	genomewide	genomewide	PROPN
aji-174	125	5	association	association	NOUN
aji-174	125	6	studies	study	NOUN
aji-174	125	7	(	(	PUNCT
aji-174	125	8	gwas	gwas	PROPN
aji-174	125	9	)	)	PUNCT
aji-174	125	10	has	have	AUX
aji-174	125	11	been	be	AUX
aji-174	125	12	instrumental	instrumental	ADJ
aji-174	125	13	,	,	PUNCT
aji-174	125	14	identifying	identify	VERB
aji-174	125	15	over	over	ADP
aji-174	125	16	hundreds	hundred	NOUN
aji-174	125	17	of	of	ADP
aji-174	125	18	susceptibility	susceptibility	NOUN
aji-174	125	19	loci	locus	NOUN
aji-174	125	20	across	across	ADP
aji-174	125	21	various	various	ADJ
aji-174	125	22	imids	imid	NOUN
aji-174	125	23	.	.	PUNCT
aji-174	126	1	these	these	DET
aji-174	126	2	studies	study	NOUN
aji-174	126	3	have	have	AUX
aji-174	126	4	robustly	robustly	ADV
aji-174	126	5	confirmed	confirm	VERB
aji-174	126	6	the	the	DET
aji-174	126	7	paramount	paramount	ADJ
aji-174	126	8	importance	importance	NOUN
aji-174	126	9	of	of	ADP
aji-174	126	10	the	the	DET
aji-174	126	11	major	major	ADJ
aji-174	126	12	histocompatibility	histocompatibility	NOUN
aji-174	126	13	complex	complex	NOUN
aji-174	126	14	(	(	PUNCT
aji-174	126	15	mhc	mhc	PROPN
aji-174	126	16	)	)	PUNCT
aji-174	126	17	region	region	NOUN
aji-174	126	18	and	and	CCONJ
aji-174	126	19	highlighted	highlight	VERB
aji-174	126	20	key	key	ADJ
aji-174	126	21	pathways	pathway	NOUN
aji-174	126	22	involved	involve	VERB
aji-174	126	23	in	in	ADP
aji-174	126	24	immune	immune	ADJ
aji-174	126	25	cell	cell	NOUN
aji-174	126	26	signaling	signal	VERB
aji-174	126	27	,	,	PUNCT
aji-174	126	28	cytokine	cytokine	ADJ
aji-174	126	29	production	production	NOUN
aji-174	126	30	,	,	PUNCT
aji-174	126	31	and	and	CCONJ
aji-174	126	32	lymphocyte	lymphocyte	ADJ
aji-174	126	33	activation	activation	NOUN
aji-174	126	34	(	(	PUNCT
aji-174	126	35	ausserwinkler	ausserwinkler	NOUN
aji-174	126	36	et	et	PROPN
aji-174	126	37	al	al	PROPN
aji-174	126	38	.	.	PROPN
aji-174	126	39	,	,	PUNCT
aji-174	126	40	2025	2025	NUM
aji-174	126	41	;	;	PUNCT
aji-174	126	42	arneth	arneth	PROPN
aji-174	126	43	,	,	PUNCT
aji-174	126	44	2024	2024	NUM
aji-174	126	45	)	)	PUNCT
aji-174	126	46	.	.	PUNCT
aji-174	127	1	however	however	ADV
aji-174	127	2	,	,	PUNCT
aji-174	127	3	a	a	DET
aji-174	127	4	critical	critical	ADJ
aji-174	127	5	paradox	paradox	NOUN
aji-174	127	6	emerged	emerge	VERB
aji-174	127	7	from	from	ADP
aji-174	127	8	this	this	DET
aji-174	127	9	genetic	genetic	ADJ
aji-174	127	10	data	datum	NOUN
aji-174	127	11	:	:	PUNCT
aji-174	127	12	the	the	DET
aji-174	127	13	identified	identify	VERB
aji-174	127	14	risk	risk	NOUN
aji-174	127	15	alleles	allele	NOUN
aji-174	127	16	,	,	PUNCT
aji-174	127	17	while	while	SCONJ
aji-174	127	18	statistically	statistically	ADV
aji-174	127	19	significant	significant	ADJ
aji-174	127	20	,	,	PUNCT
aji-174	127	21	often	often	ADV
aji-174	127	22	confer	confer	VERB
aji-174	127	23	only	only	ADV
aji-174	127	24	a	a	DET
aji-174	127	25	modest	modest	ADJ
aji-174	127	26	increase	increase	NOUN
aji-174	127	27	in	in	ADP
aji-174	127	28	relative	relative	ADJ
aji-174	127	29	risk	risk	NOUN
aji-174	127	30	and	and	CCONJ
aji-174	127	31	exhibit	exhibit	VERB
aji-174	127	32	low	low	ADJ
aji-174	127	33	penetrance	penetrance	NOUN
aji-174	127	34	.	.	PUNCT
aji-174	128	1	this	this	PRON
aji-174	128	2	is	be	AUX
aji-174	128	3	most	most	ADV
aji-174	128	4	strikingly	strikingly	ADV
aji-174	128	5	evidenced	evidence	VERB
aji-174	128	6	by	by	ADP
aji-174	128	7	the	the	DET
aji-174	128	8	significant	significant	ADJ
aji-174	128	9	discordance	discordance	NOUN
aji-174	128	10	rates	rate	NOUN
aji-174	128	11	observed	observe	VERB
aji-174	128	12	in	in	ADP
aji-174	128	13	monozygotic	monozygotic	ADJ
aji-174	128	14	(	(	PUNCT
aji-174	128	15	identical	identical	ADJ
aji-174	128	16	)	)	PUNCT
aji-174	128	17	twins	twin	NOUN
aji-174	128	18	,	,	PUNCT
aji-174	128	19	who	who	PRON
aji-174	128	20	share	share	VERB
aji-174	128	21	nearly	nearly	ADV
aji-174	128	22	100	100	NUM
aji-174	128	23	%	%	NOUN
aji-174	128	24	of	of	ADP
aji-174	128	25	their	their	PRON
aji-174	128	26	genetic	genetic	ADJ
aji-174	128	27	sequence	sequence	NOUN
aji-174	128	28	.	.	PUNCT
aji-174	129	1	for	for	ADP
aji-174	129	2	example	example	NOUN
aji-174	129	3	,	,	PUNCT
aji-174	129	4	concordance	concordance	NOUN
aji-174	129	5	rates	rate	NOUN
aji-174	129	6	for	for	ADP
aji-174	129	7	sle	sle	PROPN
aji-174	129	8	,	,	PUNCT
aji-174	129	9	ra	ra	PROPN
aji-174	129	10	,	,	PUNCT
aji-174	129	11	and	and	CCONJ
aji-174	129	12	ms	ms	NOUN
aji-174	129	13	typically	typically	ADV
aji-174	129	14	range	range	VERB
aji-174	129	15	from	from	ADP
aji-174	129	16	only	only	ADV
aji-174	129	17	25	25	NUM
aji-174	129	18	%	%	NOUN
aji-174	129	19	to	to	PART
aji-174	129	20	40	40	NUM
aji-174	129	21	%	%	NOUN
aji-174	129	22	,	,	PUNCT
aji-174	129	23	leaving	leave	VERB
aji-174	129	24	a	a	DET
aji-174	129	25	substantial	substantial	ADJ
aji-174	129	26	portion	portion	NOUN
aji-174	129	27	of	of	ADP
aji-174	129	28	disease	disease	NOUN
aji-174	129	29	risk	risk	NOUN
aji-174	129	30	unexplained	unexplaine	VERB
aji-174	129	31	by	by	ADP
aji-174	129	32	genetics	genetic	NOUN
aji-174	129	33	alone	alone	ADV
aji-174	129	34	(	(	PUNCT
aji-174	129	35	khan	khan	PROPN
aji-174	129	36	et	et	PROPN
aji-174	129	37	al	al	PROPN
aji-174	129	38	.	.	PROPN
aji-174	129	39	,	,	PUNCT
aji-174	129	40	2024	2024	NUM
aji-174	129	41	;	;	PUNCT
aji-174	129	42	ates	ates	PROPN
aji-174	129	43	et	et	PROPN
aji-174	129	44	al	al	PROPN
aji-174	129	45	.	.	PROPN
aji-174	129	46	,	,	PUNCT
aji-174	129	47	2025	2025	NUM
aji-174	129	48	)	)	PUNCT
aji-174	129	49	.	.	PUNCT
aji-174	130	1	this	this	DET
aji-174	130	2	compelling	compelling	ADJ
aji-174	130	3	"	"	PUNCT
aji-174	130	4	heritability	heritability	NOUN
aji-174	130	5	gap	gap	NOUN
aji-174	130	6	"	"	PUNCT
aji-174	130	7	strongly	strongly	ADV
aji-174	130	8	implies	imply	VERB
aji-174	130	9	that	that	SCONJ
aji-174	130	10	non	non	ADJ
aji-174	130	11	-	-	ADJ
aji-174	130	12	genetic	genetic	ADJ
aji-174	130	13	factors	factor	NOUN
aji-174	130	14	play	play	VERB
aji-174	130	15	a	a	DET
aji-174	130	16	dominant	dominant	ADJ
aji-174	130	17	role	role	NOUN
aji-174	130	18	in	in	ADP
aji-174	130	19	determining	determine	VERB
aji-174	130	20	whether	whether	SCONJ
aji-174	130	21	a	a	DET
aji-174	130	22	genetically	genetically	ADV
aji-174	130	23	susceptible	susceptible	ADJ
aji-174	130	24	individual	individual	NOUN
aji-174	130	25	will	will	AUX
aji-174	130	26	ultimately	ultimately	ADV
aji-174	130	27	develop	develop	VERB
aji-174	130	28	clinical	clinical	ADJ
aji-174	130	29	disease	disease	NOUN
aji-174	130	30	.	.	PUNCT
aji-174	131	1	this	this	DET
aji-174	131	2	gap	gap	NOUN
aji-174	131	3	is	be	AUX
aji-174	131	4	bridged	bridge	VERB
aji-174	131	5	by	by	ADP
aji-174	131	6	epigenetics	epigenetic	NOUN
aji-174	131	7	,	,	PUNCT
aji-174	131	8	a	a	DET
aji-174	131	9	discipline	discipline	NOUN
aji-174	131	10	that	that	PRON
aji-174	131	11	has	have	AUX
aji-174	131	12	revolutionized	revolutionize	VERB
aji-174	131	13	our	our	PRON
aji-174	131	14	understanding	understanding	NOUN
aji-174	131	15	of	of	ADP
aji-174	131	16	gene	gene	NOUN
aji-174	131	17	regulation	regulation	NOUN
aji-174	131	18	.	.	PUNCT
aji-174	132	1	epigenetics	epigenetic	NOUN
aji-174	132	2	refers	refer	VERB
aji-174	132	3	to	to	ADP
aji-174	132	4	the	the	DET
aji-174	132	5	study	study	NOUN
aji-174	132	6	of	of	ADP
aji-174	132	7	heritable	heritable	ADJ
aji-174	132	8	changes	change	NOUN
aji-174	132	9	in	in	ADP
aji-174	132	10	gene	gene	NOUN
aji-174	132	11	expression	expression	NOUN
aji-174	132	12	and	and	CCONJ
aji-174	132	13	cellular	cellular	ADJ
aji-174	132	14	phenotype	phenotype	NOUN
aji-174	132	15	that	that	PRON
aji-174	132	16	occur	occur	VERB
aji-174	132	17	without	without	ADP
aji-174	132	18	alterations	alteration	NOUN
aji-174	132	19	to	to	ADP
aji-174	132	20	the	the	DET
aji-174	132	21	underlying	underlying	ADJ
aji-174	132	22	dna	dna	PROPN
aji-174	132	23	nucleotide	nucleotide	NOUN
aji-174	132	24	sequence	sequence	NOUN
aji-174	132	25	(	(	PUNCT
aji-174	132	26	lin	lin	PROPN
aji-174	132	27	et	et	PROPN
aji-174	132	28	al	al	PROPN
aji-174	132	29	.	.	PROPN
aji-174	132	30	,2024	,2024	PROPN
aji-174	132	31	;	;	PUNCT
aji-174	133	1	gibson	gibson	PROPN
aji-174	133	2	et	et	PROPN
aji-174	133	3	al	al	PROPN
aji-174	133	4	.	.	PROPN
aji-174	133	5	,	,	PUNCT
aji-174	133	6	2022	2022	NUM
aji-174	133	7	)	)	PUNCT
aji-174	133	8	.	.	PUNCT
aji-174	134	1	these	these	DET
aji-174	134	2	mechanisms	mechanism	NOUN
aji-174	134	3	,	,	PUNCT
aji-174	134	4	primarily	primarily	ADV
aji-174	134	5	dna	dna	PROPN
aji-174	134	6	methylation	methylation	NOUN
aji-174	134	7	,	,	PUNCT
aji-174	134	8	histone	histone	NOUN
aji-174	134	9	modifications	modification	NOUN
aji-174	134	10	,	,	PUNCT
aji-174	134	11	and	and	CCONJ
aji-174	134	12	non	non	ADJ
aji-174	134	13	-	-	ADJ
aji-174	134	14	coding	code	VERB
aji-174	134	15	rna	rna	NOUN
aji-174	134	16	-	-	PUNCT
aji-174	134	17	associated	associate	VERB
aji-174	134	18	gene	gene	NOUN
aji-174	134	19	silencing	silencing	NOUN
aji-174	134	20	,	,	PUNCT
aji-174	134	21	act	act	VERB
aji-174	134	22	as	as	ADP
aji-174	134	23	dynamic	dynamic	ADJ
aji-174	134	24	regulators	regulator	NOUN
aji-174	134	25	of	of	ADP
aji-174	134	26	chromatin	chromatin	NOUN
aji-174	134	27	architecture	architecture	NOUN
aji-174	134	28	,	,	PUNCT
aji-174	134	29	determining	determine	VERB
aji-174	134	30	the	the	DET
aji-174	134	31	accessibility	accessibility	NOUN
aji-174	134	32	of	of	ADP
aji-174	134	33	genetic	genetic	ADJ
aji-174	134	34	information	information	NOUN
aji-174	134	35	to	to	ADP
aji-174	134	36	the	the	DET
aji-174	134	37	transcriptional	transcriptional	ADJ
aji-174	134	38	machinery	machinery	NOUN
aji-174	134	39	.	.	PUNCT
aji-174	135	1	crucially	crucially	ADV
aji-174	135	2	,	,	PUNCT
aji-174	135	3	the	the	DET
aji-174	135	4	epigenetic	epigenetic	ADJ
aji-174	135	5	landscape	landscape	NOUN
aji-174	135	6	is	be	AUX
aji-174	135	7	plastic	plastic	ADJ
aji-174	135	8	and	and	CCONJ
aji-174	135	9	can	can	AUX
aji-174	135	10	be	be	AUX
aji-174	135	11	actively	actively	ADV
aji-174	135	12	shaped	shape	VERB
aji-174	135	13	by	by	ADP
aji-174	135	14	a	a	DET
aji-174	135	15	myriad	myriad	NOUN
aji-174	135	16	of	of	ADP
aji-174	135	17	environmental	environmental	ADJ
aji-174	135	18	exposures	exposure	NOUN
aji-174	135	19	,	,	PUNCT
aji-174	135	20	including	include	VERB
aji-174	135	21	infectious	infectious	ADJ
aji-174	135	22	agents	agent	NOUN
aji-174	135	23	(	(	PUNCT
aji-174	135	24	e.g.	e.g.	ADV
aji-174	135	25	,	,	PUNCT
aji-174	135	26	epstein	epstein	PROPN
aji-174	135	27	-	-	PUNCT
aji-174	135	28	barr	barr	PROPN
aji-174	135	29	virus	virus	PROPN
aji-174	135	30	)	)	PUNCT
aji-174	135	31	,	,	PUNCT
aji-174	135	32	tobacco	tobacco	NOUN
aji-174	135	33	smoke	smoke	NOUN
aji-174	135	34	,	,	PUNCT
aji-174	135	35	hormonal	hormonal	ADJ
aji-174	135	36	changes	change	NOUN
aji-174	135	37	,	,	PUNCT
aji-174	135	38	dietary	dietary	ADJ
aji-174	135	39	components	component	NOUN
aji-174	135	40	,	,	PUNCT
aji-174	135	41	and	and	CCONJ
aji-174	135	42	pollutants	pollutant	NOUN
aji-174	135	43	(	(	PUNCT
aji-174	135	44	kwon	kwon	PROPN
aji-174	135	45	et	et	PROPN
aji-174	135	46	al	al	PROPN
aji-174	135	47	.	.	PROPN
aji-174	135	48	,	,	PUNCT
aji-174	135	49	2024	2024	NUM
aji-174	135	50	;	;	PUNCT
aji-174	135	51	kaszycki	kaszycki	PROPN
aji-174	135	52	and	and	CCONJ
aji-174	135	53	kim	kim	PROPN
aji-174	135	54	,	,	PUNCT
aji-174	135	55	2025	2025	NUM
aji-174	135	56	)	)	PUNCT
aji-174	135	57	.	.	PUNCT
aji-174	136	1	these	these	DET
aji-174	136	2	factors	factor	NOUN
aji-174	136	3	can	can	AUX
aji-174	136	4	initiate	initiate	VERB
aji-174	136	5	stable	stable	ADJ
aji-174	136	6	epigenetic	epigenetic	ADJ
aji-174	136	7	reprogramming	reprogramming	NOUN
aji-174	136	8	within	within	ADP
aji-174	136	9	immune	immune	ADJ
aji-174	136	10	cells	cell	NOUN
aji-174	136	11	,	,	PUNCT
aji-174	136	12	potentially	potentially	ADV
aji-174	136	13	leading	lead	VERB
aji-174	136	14	to	to	ADP
aji-174	136	15	the	the	DET
aji-174	136	16	sustained	sustained	ADJ
aji-174	136	17	overexpression	overexpression	NOUN
aji-174	136	18	of	of	ADP
aji-174	136	19	proinflammatory	proinflammatory	ADJ
aji-174	136	20	genes	gene	NOUN
aji-174	136	21	or	or	CCONJ
aji-174	136	22	the	the	DET
aji-174	136	23	silencing	silencing	NOUN
aji-174	136	24	of	of	ADP
aji-174	136	25	key	key	ADJ
aji-174	136	26	immunoregulatory	immunoregulatory	ADJ
aji-174	136	27	pathways	pathway	NOUN
aji-174	136	28	.	.	PUNCT
aji-174	137	1	this	this	DET
aji-174	137	2	review	review	NOUN
aji-174	137	3	manuscript	manuscript	NOUN
aji-174	137	4	synthesizes	synthesize	VERB
aji-174	137	5	current	current	ADJ
aji-174	137	6	evidence	evidence	NOUN
aji-174	137	7	positing	posit	VERB
aji-174	137	8	that	that	SCONJ
aji-174	137	9	epigenetic	epigenetic	ADJ
aji-174	137	10	dysregulation	dysregulation	NOUN
aji-174	137	11	serves	serve	VERB
aji-174	137	12	as	as	ADP
aji-174	137	13	the	the	DET
aji-174	137	14	crucial	crucial	ADJ
aji-174	137	15	mechanistic	mechanistic	ADJ
aji-174	137	16	link	link	NOUN
aji-174	137	17	between	between	ADP
aji-174	137	18	genetic	genetic	ADJ
aji-174	137	19	susceptibility	susceptibility	NOUN
aji-174	137	20	and	and	CCONJ
aji-174	137	21	environmental	environmental	ADJ
aji-174	137	22	triggers	trigger	NOUN
aji-174	137	23	in	in	ADP
aji-174	137	24	the	the	DET
aji-174	137	25	pathogenesis	pathogenesis	NOUN
aji-174	137	26	of	of	ADP
aji-174	137	27	immune	immune	NOUN
aji-174	137	28	-	-	PUNCT
aji-174	137	29	mediated	mediate	VERB
aji-174	137	30	diseases	disease	NOUN
aji-174	137	31	.	.	PUNCT
aji-174	138	1	we	we	PRON
aji-174	138	2	will	will	AUX
aji-174	138	3	detail	detail	VERB
aji-174	138	4	the	the	DET
aji-174	138	5	aberrant	aberrant	ADJ
aji-174	138	6	epigenetic	epigenetic	ADJ
aji-174	138	7	patterns	pattern	NOUN
aji-174	138	8	,	,	PUNCT
aji-174	138	9	the	the	DET
aji-174	138	10	"	"	PUNCT
aji-174	138	11	epigenome	epigenome	NOUN
aji-174	138	12	"	"	PUNCT
aji-174	138	13	characteristic	characteristic	NOUN
aji-174	138	14	of	of	ADP
aji-174	138	15	major	major	ADJ
aji-174	138	16	imids	imid	NOUN
aji-174	138	17	,	,	PUNCT
aji-174	138	18	focusing	focus	VERB
aji-174	138	19	on	on	ADP
aji-174	138	20	specific	specific	ADJ
aji-174	138	21	immune	immune	ADJ
aji-174	138	22	cell	cell	NOUN
aji-174	138	23	subsets	subset	NOUN
aji-174	138	24	.	.	PUNCT
aji-174	139	1	furthermore	furthermore	ADV
aji-174	139	2	,	,	PUNCT
aji-174	139	3	we	we	PRON
aji-174	139	4	will	will	AUX
aji-174	139	5	explore	explore	VERB
aji-174	139	6	the	the	DET
aji-174	139	7	profound	profound	ADJ
aji-174	139	8	translational	translational	ADJ
aji-174	139	9	implications	implication	NOUN
aji-174	139	10	of	of	ADP
aji-174	139	11	this	this	DET
aji-174	139	12	field	field	NOUN
aji-174	139	13	,	,	PUNCT
aji-174	139	14	discussing	discuss	VERB
aji-174	139	15	the	the	DET
aji-174	139	16	potential	potential	NOUN
aji-174	139	17	of	of	ADP
aji-174	139	18	epigenetic	epigenetic	ADJ
aji-174	139	19	marks	mark	NOUN
aji-174	139	20	as	as	ADP
aji-174	139	21	novel	novel	ADJ
aji-174	139	22	biomarkers	biomarker	NOUN
aji-174	139	23	for	for	ADP
aji-174	139	24	diagnosis	diagnosis	NOUN
aji-174	139	25	and	and	CCONJ
aji-174	139	26	prognostication	prognostication	NOUN
aji-174	139	27	and	and	CCONJ
aji-174	139	28	surveying	survey	VERB
aji-174	139	29	the	the	DET
aji-174	139	30	promising	promising	ADJ
aji-174	139	31	frontier	frontier	NOUN
aji-174	139	32	of	of	ADP
aji-174	139	33	epigeneticbased	epigeneticbased	ADJ
aji-174	139	34	therapeutics	therapeutic	NOUN
aji-174	139	35	aimed	aim	VERB
aji-174	139	36	at	at	ADP
aji-174	139	37	reversing	reverse	VERB
aji-174	139	38	pathogenic	pathogenic	ADJ
aji-174	139	39	marks	mark	NOUN
aji-174	139	40	and	and	CCONJ
aji-174	139	41	restoring	restore	VERB
aji-174	139	42	immune	immune	ADJ
aji-174	139	43	homeostasis	homeostasis	NOUN
aji-174	139	44	.	.	PUNCT
aji-174	140	1	2	2	X
aji-174	140	2	.	.	X
aji-174	140	3	fundamental	fundamental	ADJ
aji-174	140	4	epigenetic	epigenetic	ADJ
aji-174	140	5	mechanisms	mechanism	NOUN
aji-174	140	6	epigenetic	epigenetic	ADJ
aji-174	140	7	regulation	regulation	NOUN
aji-174	140	8	provides	provide	VERB
aji-174	140	9	a	a	DET
aji-174	140	10	dynamic	dynamic	ADJ
aji-174	140	11	and	and	CCONJ
aji-174	140	12	heritable	heritable	ADJ
aji-174	140	13	layer	layer	NOUN
aji-174	140	14	of	of	ADP
aji-174	140	15	control	control	NOUN
aji-174	140	16	over	over	ADP
aji-174	140	17	gene	gene	NOUN
aji-174	140	18	expression	expression	NOUN
aji-174	140	19	,	,	PUNCT
aji-174	140	20	ajibola	ajibola	PROPN
aji-174	140	21	and	and	CCONJ
aji-174	140	22	ayodele	ayodele	PROPN
aji-174	140	23	;	;	PUNCT
aji-174	140	24	asian	asian	PROPN
aji-174	140	25	j.	j.	PROPN
aji-174	140	26	immunol	immunol	PROPN
aji-174	140	27	.	.	PROPN
aji-174	140	28	,	,	PUNCT
aji-174	140	29	vol	vol	NOUN
aji-174	140	30	.	.	PROPN
aji-174	140	31	8	8	NUM
aji-174	140	32	,	,	PUNCT
aji-174	140	33	no	no	INTJ
aji-174	140	34	.	.	NOUN
aji-174	140	35	1	1	NUM
aji-174	140	36	,	,	PUNCT
aji-174	140	37	pp	pp	ADJ
aji-174	140	38	.	.	PUNCT
aji-174	141	1	230	230	NUM
aji-174	141	2	-	-	SYM
aji-174	141	3	241	241	NUM
aji-174	141	4	,	,	PUNCT
aji-174	141	5	2025	2025	NUM
aji-174	141	6	;	;	PUNCT
aji-174	141	7	article	article	NOUN
aji-174	141	8	no.aji.144830	no.aji.144830	NOUN
aji-174	141	9	232	232	NUM
aji-174	141	10	enabling	enable	VERB
aji-174	141	11	cellular	cellular	ADJ
aji-174	141	12	differentiation	differentiation	NOUN
aji-174	141	13	and	and	CCONJ
aji-174	141	14	plasticity	plasticity	NOUN
aji-174	141	15	in	in	ADP
aji-174	141	16	response	response	NOUN
aji-174	141	17	to	to	ADP
aji-174	141	18	environmental	environmental	ADJ
aji-174	141	19	cues	cue	NOUN
aji-174	141	20	without	without	ADP
aji-174	141	21	altering	alter	VERB
aji-174	141	22	the	the	DET
aji-174	141	23	primary	primary	ADJ
aji-174	141	24	dna	dna	NOUN
aji-174	141	25	sequence	sequence	NOUN
aji-174	141	26	.	.	PUNCT
aji-174	142	1	in	in	ADP
aji-174	142	2	the	the	DET
aji-174	142	3	immune	immune	ADJ
aji-174	142	4	system	system	NOUN
aji-174	142	5	,	,	PUNCT
aji-174	142	6	these	these	DET
aji-174	142	7	mechanisms	mechanism	NOUN
aji-174	142	8	are	be	AUX
aji-174	142	9	paramount	paramount	ADJ
aji-174	142	10	for	for	ADP
aji-174	142	11	the	the	DET
aji-174	142	12	development	development	NOUN
aji-174	142	13	,	,	PUNCT
aji-174	142	14	activation	activation	NOUN
aji-174	142	15	,	,	PUNCT
aji-174	142	16	and	and	CCONJ
aji-174	142	17	termination	termination	NOUN
aji-174	142	18	of	of	ADP
aji-174	142	19	responses	response	NOUN
aji-174	142	20	,	,	PUNCT
aji-174	142	21	ensuring	ensure	VERB
aji-174	142	22	a	a	DET
aji-174	142	23	precise	precise	ADJ
aji-174	142	24	balance	balance	NOUN
aji-174	142	25	between	between	ADP
aji-174	142	26	effective	effective	ADJ
aji-174	142	27	pathogen	pathogen	NOUN
aji-174	142	28	clearance	clearance	NOUN
aji-174	142	29	and	and	CCONJ
aji-174	142	30	self	self	NOUN
aji-174	142	31	-	-	PUNCT
aji-174	142	32	tolerance	tolerance	NOUN
aji-174	142	33	.	.	PUNCT
aji-174	143	1	the	the	DET
aji-174	143	2	dysregulation	dysregulation	NOUN
aji-174	143	3	of	of	ADP
aji-174	143	4	these	these	DET
aji-174	143	5	processes	process	NOUN
aji-174	143	6	is	be	AUX
aji-174	143	7	a	a	DET
aji-174	143	8	cornerstone	cornerstone	NOUN
aji-174	143	9	of	of	ADP
aji-174	143	10	autoimmune	autoimmune	ADJ
aji-174	143	11	pathology	pathology	NOUN
aji-174	143	12	.	.	PUNCT
aji-174	144	1	the	the	DET
aji-174	144	2	three	three	NUM
aji-174	144	3	primary	primary	ADJ
aji-174	144	4	,	,	PUNCT
aji-174	144	5	interconnected	interconnected	ADJ
aji-174	144	6	epigenetic	epigenetic	ADJ
aji-174	144	7	mechanisms	mechanism	NOUN
aji-174	144	8	are	be	AUX
aji-174	144	9	dna	dna	PROPN
aji-174	144	10	methylation	methylation	NOUN
aji-174	144	11	,	,	PUNCT
aji-174	144	12	histone	histone	NOUN
aji-174	144	13	modifications	modification	NOUN
aji-174	144	14	,	,	PUNCT
aji-174	144	15	and	and	CCONJ
aji-174	144	16	non	non	ADJ
aji-174	144	17	-	-	ADJ
aji-174	144	18	coding	code	VERB
aji-174	144	19	rna	rna	NOUN
aji-174	144	20	-	-	PUNCT
aji-174	144	21	associated	associate	VERB
aji-174	144	22	silencing	silencing	NOUN
aji-174	144	23	.	.	PUNCT
aji-174	145	1	restoring	restore	VERB
aji-174	145	2	immune	immune	ADJ
aji-174	145	3	homeostasis	homeostasis	NOUN
aji-174	145	4	.	.	PUNCT
aji-174	146	1	2.1	2.1	NUM
aji-174	146	2	dna	dna	PROPN
aji-174	146	3	methylation	methylation	NOUN
aji-174	146	4	dna	dna	PROPN
aji-174	146	5	methylation	methylation	NOUN
aji-174	146	6	is	be	AUX
aji-174	146	7	the	the	DET
aji-174	146	8	most	most	ADV
aji-174	146	9	extensively	extensively	ADV
aji-174	146	10	studied	study	VERB
aji-174	146	11	epigenetic	epigenetic	ADJ
aji-174	146	12	modification	modification	NOUN
aji-174	146	13	in	in	ADP
aji-174	146	14	mammals	mammal	NOUN
aji-174	146	15	.	.	PUNCT
aji-174	147	1	it	it	PRON
aji-174	147	2	involves	involve	VERB
aji-174	147	3	the	the	DET
aji-174	147	4	covalent	covalent	ADJ
aji-174	147	5	addition	addition	NOUN
aji-174	147	6	of	of	ADP
aji-174	147	7	a	a	DET
aji-174	147	8	methyl	methyl	NOUN
aji-174	147	9	group	group	NOUN
aji-174	147	10	to	to	ADP
aji-174	147	11	the	the	DET
aji-174	147	12	5	5	NUM
aji-174	147	13	'	'	PART
aji-174	147	14	position	position	NOUN
aji-174	147	15	of	of	ADP
aji-174	147	16	a	a	DET
aji-174	147	17	cytosine	cytosine	NOUN
aji-174	147	18	ring	ring	NOUN
aji-174	147	19	,	,	PUNCT
aji-174	147	20	primarily	primarily	ADV
aji-174	147	21	within	within	ADP
aji-174	147	22	cpg	cpg	NOUN
aji-174	147	23	dinucleotide	dinucleotide	NOUN
aji-174	147	24	sequences	sequence	NOUN
aji-174	147	25	.	.	PUNCT
aji-174	148	1	dense	dense	ADJ
aji-174	148	2	clusters	cluster	NOUN
aji-174	148	3	of	of	ADP
aji-174	148	4	cpg	cpg	NOUN
aji-174	148	5	sites	site	NOUN
aji-174	148	6	,	,	PUNCT
aji-174	148	7	known	know	VERB
aji-174	148	8	as	as	ADP
aji-174	148	9	cpg	cpg	PROPN
aji-174	148	10	islands	island	NOUN
aji-174	148	11	,	,	PUNCT
aji-174	148	12	are	be	AUX
aji-174	148	13	often	often	ADV
aji-174	148	14	found	find	VERB
aji-174	148	15	in	in	ADP
aji-174	148	16	gene	gene	NOUN
aji-174	148	17	promoter	promoter	NOUN
aji-174	148	18	regions	region	NOUN
aji-174	148	19	.	.	PUNCT
aji-174	149	1	methylation	methylation	NOUN
aji-174	149	2	of	of	ADP
aji-174	149	3	these	these	DET
aji-174	149	4	islands	island	NOUN
aji-174	149	5	typically	typically	ADV
aji-174	149	6	leads	lead	VERB
aji-174	149	7	to	to	ADP
aji-174	149	8	transcriptional	transcriptional	ADJ
aji-174	149	9	repression	repression	NOUN
aji-174	149	10	by	by	ADP
aji-174	149	11	physically	physically	ADV
aji-174	149	12	impeding	impede	VERB
aji-174	149	13	the	the	DET
aji-174	149	14	binding	binding	NOUN
aji-174	149	15	of	of	ADP
aji-174	149	16	transcription	transcription	NOUN
aji-174	149	17	factors	factor	NOUN
aji-174	149	18	and	and	CCONJ
aji-174	149	19	by	by	ADP
aji-174	149	20	recruiting	recruit	VERB
aji-174	149	21	proteins	protein	NOUN
aji-174	149	22	such	such	ADJ
aji-174	149	23	as	as	ADP
aji-174	149	24	methyl	methyl	NOUN
aji-174	149	25	-	-	PUNCT
aji-174	149	26	cpg	cpg	NOUN
aji-174	149	27	-	-	PUNCT
aji-174	149	28	binding	bind	VERB
aji-174	149	29	domain	domain	NOUN
aji-174	149	30	proteins	protein	NOUN
aji-174	149	31	(	(	PUNCT
aji-174	149	32	mbds	mbds	NOUN
aji-174	149	33	)	)	PUNCT
aji-174	149	34	,	,	PUNCT
aji-174	149	35	which	which	PRON
aji-174	149	36	then	then	ADV
aji-174	149	37	attract	attract	VERB
aji-174	149	38	histone	histone	NOUN
aji-174	149	39	deacetylases	deacetylase	NOUN
aji-174	149	40	and	and	CCONJ
aji-174	149	41	other	other	ADJ
aji-174	149	42	chromatin	chromatin	NOUN
aji-174	149	43	-	-	PUNCT
aji-174	149	44	remodeling	remodeling	NOUN
aji-174	149	45	complexes	complex	NOUN
aji-174	149	46	to	to	PART
aji-174	149	47	establish	establish	VERB
aji-174	149	48	a	a	DET
aji-174	149	49	closed	closed	ADJ
aji-174	149	50	,	,	PUNCT
aji-174	149	51	silent	silent	ADJ
aji-174	149	52	chromatin	chromatin	NOUN
aji-174	149	53	state	state	NOUN
aji-174	149	54	(	(	PUNCT
aji-174	149	55	harris	harris	PROPN
aji-174	149	56	et	et	PROPN
aji-174	149	57	al	al	PROPN
aji-174	149	58	,	,	PUNCT
aji-174	149	59	2025	2025	NUM
aji-174	149	60	;	;	PUNCT
aji-174	149	61	smith	smith	PROPN
aji-174	149	62	et	et	PROPN
aji-174	149	63	al	al	PROPN
aji-174	149	64	.	.	PROPN
aji-174	149	65	,	,	PUNCT
aji-174	149	66	2025	2025	NUM
aji-174	149	67	)	)	PUNCT
aji-174	149	68	.	.	PUNCT
aji-174	150	1	the	the	DET
aji-174	150	2	establishment	establishment	NOUN
aji-174	150	3	and	and	CCONJ
aji-174	150	4	maintenance	maintenance	NOUN
aji-174	150	5	of	of	ADP
aji-174	150	6	dna	dna	PROPN
aji-174	150	7	methylation	methylation	NOUN
aji-174	150	8	patterns	pattern	NOUN
aji-174	150	9	are	be	AUX
aji-174	150	10	catalyzed	catalyze	VERB
aji-174	150	11	by	by	ADP
aji-174	150	12	a	a	DET
aji-174	150	13	family	family	NOUN
aji-174	150	14	of	of	ADP
aji-174	150	15	enzymes	enzyme	NOUN
aji-174	150	16	called	call	VERB
aji-174	150	17	dna	dna	PROPN
aji-174	150	18	methyltransferases	methyltransferase	NOUN
aji-174	150	19	(	(	PUNCT
aji-174	150	20	dnmts	dnmt	VERB
aji-174	150	21	)	)	PUNCT
aji-174	150	22	.	.	PUNCT
aji-174	151	1	dnmt3a	dnmt3a	PROPN
aji-174	151	2	and	and	CCONJ
aji-174	151	3	dnmt3b	dnmt3b	NOUN
aji-174	151	4	are	be	AUX
aji-174	151	5	responsible	responsible	ADJ
aji-174	151	6	for	for	ADP
aji-174	151	7	de	de	X
aji-174	151	8	novo	novo	NOUN
aji-174	151	9	methylation	methylation	NOUN
aji-174	151	10	,	,	PUNCT
aji-174	151	11	setting	set	VERB
aji-174	151	12	up	up	ADP
aji-174	151	13	new	new	ADJ
aji-174	151	14	methylation	methylation	NOUN
aji-174	151	15	patterns	pattern	NOUN
aji-174	151	16	during	during	ADP
aji-174	151	17	embryonic	embryonic	ADJ
aji-174	151	18	development	development	NOUN
aji-174	151	19	.	.	PUNCT
aji-174	152	1	dnmt1	dnmt1	PROPN
aji-174	152	2	,	,	PUNCT
aji-174	152	3	the	the	DET
aji-174	152	4	maintenance	maintenance	NOUN
aji-174	152	5	methyltransferase	methyltransferase	NOUN
aji-174	152	6	,	,	PUNCT
aji-174	152	7	faithfully	faithfully	ADV
aji-174	152	8	copies	copy	VERB
aji-174	152	9	methylation	methylation	NOUN
aji-174	152	10	patterns	pattern	NOUN
aji-174	152	11	to	to	ADP
aji-174	152	12	the	the	DET
aji-174	152	13	daughter	daughter	NOUN
aji-174	152	14	strand	strand	NOUN
aji-174	152	15	during	during	ADP
aji-174	152	16	dna	dna	PROPN
aji-174	152	17	replication	replication	NOUN
aji-174	152	18	,	,	PUNCT
aji-174	152	19	ensuring	ensure	VERB
aji-174	152	20	heritability	heritability	NOUN
aji-174	152	21	of	of	ADP
aji-174	152	22	the	the	DET
aji-174	152	23	epigenetic	epigenetic	ADJ
aji-174	152	24	mark	mark	NOUN
aji-174	152	25	through	through	ADP
aji-174	152	26	cell	cell	NOUN
aji-174	152	27	divisions	division	NOUN
aji-174	152	28	(	(	PUNCT
aji-174	152	29	sarre	sarre	PROPN
aji-174	152	30	et	et	PROPN
aji-174	152	31	al	al	PROPN
aji-174	152	32	.	.	PROPN
aji-174	152	33	,	,	PUNCT
aji-174	152	34	2025	2025	NUM
aji-174	152	35	)	)	PUNCT
aji-174	152	36	.	.	PUNCT
aji-174	153	1	in	in	ADP
aji-174	153	2	the	the	DET
aji-174	153	3	context	context	NOUN
aji-174	153	4	of	of	ADP
aji-174	153	5	immunity	immunity	NOUN
aji-174	153	6	,	,	PUNCT
aji-174	153	7	dna	dna	PROPN
aji-174	153	8	methylation	methylation	NOUN
aji-174	153	9	is	be	AUX
aji-174	153	10	critical	critical	ADJ
aji-174	153	11	for	for	ADP
aji-174	153	12	processes	process	NOUN
aji-174	153	13	such	such	ADJ
aji-174	153	14	as	as	ADP
aji-174	153	15	x	x	NOUN
aji-174	153	16	-	-	NOUN
aji-174	153	17	chromosome	chromosome	NOUN
aji-174	153	18	inactivation	inactivation	NOUN
aji-174	153	19	,	,	PUNCT
aji-174	153	20	genomic	genomic	NOUN
aji-174	153	21	imprinting	imprinting	NOUN
aji-174	153	22	,	,	PUNCT
aji-174	153	23	and	and	CCONJ
aji-174	153	24	the	the	DET
aji-174	153	25	silencing	silencing	NOUN
aji-174	153	26	of	of	ADP
aji-174	153	27	endogenous	endogenous	ADJ
aji-174	153	28	retroviral	retroviral	ADJ
aji-174	153	29	elements	element	NOUN
aji-174	153	30	.	.	PUNCT
aji-174	154	1	crucially	crucially	ADV
aji-174	154	2	,	,	PUNCT
aji-174	154	3	it	it	PRON
aji-174	154	4	governs	govern	VERB
aji-174	154	5	lymphocyte	lymphocyte	ADJ
aji-174	154	6	lineage	lineage	NOUN
aji-174	154	7	commitment	commitment	NOUN
aji-174	154	8	and	and	CCONJ
aji-174	154	9	function	function	NOUN
aji-174	154	10	.	.	PUNCT
aji-174	155	1	for	for	ADP
aji-174	155	2	example	example	NOUN
aji-174	155	3	,	,	PUNCT
aji-174	155	4	the	the	DET
aji-174	155	5	differentiation	differentiation	NOUN
aji-174	155	6	of	of	ADP
aji-174	155	7	naïve	naïve	PROPN
aji-174	155	8	cd4	cd4	PROPN
aji-174	155	9	+	+	PROPN
aji-174	155	10	t	t	NOUN
aji-174	155	11	cells	cell	NOUN
aji-174	155	12	into	into	ADP
aji-174	155	13	distinct	distinct	ADJ
aji-174	155	14	effector	effector	NOUN
aji-174	155	15	subsets	subset	NOUN
aji-174	155	16	(	(	PUNCT
aji-174	155	17	th1	th1	PROPN
aji-174	155	18	,	,	PUNCT
aji-174	155	19	th2	th2	PROPN
aji-174	155	20	,	,	PUNCT
aji-174	155	21	th17	th17	PROPN
aji-174	155	22	)	)	PUNCT
aji-174	155	23	and	and	CCONJ
aji-174	155	24	immunosuppressive	immunosuppressive	ADJ
aji-174	155	25	regulatory	regulatory	ADJ
aji-174	155	26	t	t	NOUN
aji-174	155	27	cells	cell	NOUN
aji-174	155	28	(	(	PUNCT
aji-174	155	29	tregs	treg	NOUN
aji-174	155	30	)	)	PUNCT
aji-174	155	31	is	be	AUX
aji-174	155	32	orchestrated	orchestrate	VERB
aji-174	155	33	by	by	ADP
aji-174	155	34	precise	precise	ADJ
aji-174	155	35	changes	change	NOUN
aji-174	155	36	in	in	ADP
aji-174	155	37	the	the	DET
aji-174	155	38	methylation	methylation	NOUN
aji-174	155	39	status	status	NOUN
aji-174	155	40	of	of	ADP
aji-174	155	41	key	key	ADJ
aji-174	155	42	cytokine	cytokine	NOUN
aji-174	155	43	and	and	CCONJ
aji-174	155	44	transcription	transcription	NOUN
aji-174	155	45	factor	factor	NOUN
aji-174	155	46	genes	gene	NOUN
aji-174	155	47	(	(	PUNCT
aji-174	155	48	roy	roy	PROPN
aji-174	155	49	et	et	PROPN
aji-174	155	50	al	al	PROPN
aji-174	155	51	.	.	PROPN
aji-174	155	52	,	,	PUNCT
aji-174	155	53	2025	2025	NUM
aji-174	155	54	)	)	PUNCT
aji-174	155	55	.	.	PUNCT
aji-174	156	1	a	a	DET
aji-174	156	2	hallmark	hallmark	NOUN
aji-174	156	3	of	of	ADP
aji-174	156	4	many	many	ADJ
aji-174	156	5	autoimmune	autoimmune	ADJ
aji-174	156	6	diseases	disease	NOUN
aji-174	156	7	,	,	PUNCT
aji-174	156	8	particularly	particularly	ADV
aji-174	156	9	sle	sle	PROPN
aji-174	156	10	,	,	PUNCT
aji-174	156	11	is	be	AUX
aji-174	156	12	a	a	DET
aji-174	156	13	state	state	NOUN
aji-174	156	14	of	of	ADP
aji-174	156	15	global	global	ADJ
aji-174	156	16	dna	dna	PROPN
aji-174	156	17	hypomethylation	hypomethylation	NOUN
aji-174	156	18	in	in	ADP
aji-174	156	19	t	t	NOUN
aji-174	156	20	cells	cell	NOUN
aji-174	156	21	,	,	PUNCT
aji-174	156	22	which	which	PRON
aji-174	156	23	promotes	promote	VERB
aji-174	156	24	the	the	DET
aji-174	156	25	aberrant	aberrant	ADJ
aji-174	156	26	overexpression	overexpression	NOUN
aji-174	156	27	of	of	ADP
aji-174	156	28	autoimmuneassociated	autoimmuneassociated	ADJ
aji-174	156	29	genes	gene	NOUN
aji-174	156	30	(	(	PUNCT
aji-174	156	31	e.g.	e.g.	ADV
aji-174	156	32	,	,	PUNCT
aji-174	156	33	itgal	itgal	PROPN
aji-174	156	34	(	(	PUNCT
aji-174	156	35	cd11a	cd11a	NOUN
aji-174	156	36	)	)	PUNCT
aji-174	156	37	and	and	CCONJ
aji-174	156	38	tnfsf7	tnfsf7	NOUN
aji-174	156	39	(	(	PUNCT
aji-174	156	40	cd70	cd70	PROPN
aji-174	156	41	)	)	PUNCT
aji-174	156	42	)	)	PUNCT
aji-174	156	43	,	,	PUNCT
aji-174	156	44	alongside	alongside	ADP
aji-174	156	45	locus	locus	NOUN
aji-174	156	46	-	-	PUNCT
aji-174	156	47	specific	specific	ADJ
aji-174	156	48	hypermethylation	hypermethylation	NOUN
aji-174	156	49	events	event	NOUN
aji-174	156	50	that	that	PRON
aji-174	156	51	may	may	AUX
aji-174	156	52	silence	silence	VERB
aji-174	156	53	protective	protective	ADJ
aji-174	156	54	genes	gene	NOUN
aji-174	156	55	(	(	PUNCT
aji-174	156	56	deng	deng	PROPN
aji-174	156	57	et	et	PROPN
aji-174	156	58	al	al	PROPN
aji-174	156	59	.	.	PROPN
aji-174	156	60	,	,	PUNCT
aji-174	156	61	2024	2024	NUM
aji-174	156	62	)	)	PUNCT
aji-174	156	63	2.2	2.2	NUM
aji-174	156	64	histone	histone	NOUN
aji-174	156	65	post	post	ADJ
aji-174	156	66	-	-	ADJ
aji-174	156	67	translational	translational	ADJ
aji-174	156	68	modifications	modification	NOUN
aji-174	156	69	histones	histone	NOUN
aji-174	156	70	are	be	AUX
aji-174	156	71	the	the	DET
aji-174	156	72	core	core	ADJ
aji-174	156	73	protein	protein	NOUN
aji-174	156	74	components	component	NOUN
aji-174	156	75	of	of	ADP
aji-174	156	76	nucleosomes	nucleosome	NOUN
aji-174	156	77	,	,	PUNCT
aji-174	156	78	around	around	ADP
aji-174	156	79	which	which	PRON
aji-174	156	80	dna	dna	PROPN
aji-174	156	81	is	be	AUX
aji-174	156	82	wrapped	wrap	VERB
aji-174	156	83	.	.	PUNCT
aji-174	157	1	their	their	PRON
aji-174	157	2	n	n	CCONJ
aji-174	157	3	-	-	PUNCT
aji-174	157	4	terminal	terminal	ADJ
aji-174	157	5	tails	tail	NOUN
aji-174	157	6	are	be	AUX
aji-174	157	7	subject	subject	ADJ
aji-174	157	8	to	to	ADP
aji-174	157	9	over	over	ADP
aji-174	157	10	100	100	NUM
aji-174	157	11	different	different	ADJ
aji-174	157	12	post	post	ADJ
aji-174	157	13	-	-	ADJ
aji-174	157	14	translational	translational	ADJ
aji-174	157	15	modifications	modification	NOUN
aji-174	157	16	(	(	PUNCT
aji-174	157	17	ptms	ptms	NOUN
aji-174	157	18	)	)	PUNCT
aji-174	157	19	,	,	PUNCT
aji-174	157	20	including	include	VERB
aji-174	157	21	acetylation	acetylation	NOUN
aji-174	157	22	,	,	PUNCT
aji-174	157	23	methylation	methylation	NOUN
aji-174	157	24	,	,	PUNCT
aji-174	157	25	phosphorylation	phosphorylation	NOUN
aji-174	157	26	,	,	PUNCT
aji-174	157	27	ubiquitination	ubiquitination	NOUN
aji-174	157	28	,	,	PUNCT
aji-174	157	29	and	and	CCONJ
aji-174	157	30	sumoylation	sumoylation	NOUN
aji-174	157	31	.	.	PUNCT
aji-174	158	1	these	these	DET
aji-174	158	2	ptms	ptms	NOUN
aji-174	158	3	alter	alter	VERB
aji-174	158	4	the	the	DET
aji-174	158	5	electrostatic	electrostatic	ADJ
aji-174	158	6	charge	charge	NOUN
aji-174	158	7	of	of	ADP
aji-174	158	8	histones	histone	NOUN
aji-174	158	9	and	and	CCONJ
aji-174	158	10	serve	serve	VERB
aji-174	158	11	as	as	ADP
aji-174	158	12	docking	dock	VERB
aji-174	158	13	sites	site	NOUN
aji-174	158	14	for	for	ADP
aji-174	158	15	other	other	ADJ
aji-174	158	16	proteins	protein	NOUN
aji-174	158	17	,	,	PUNCT
aji-174	158	18	collectively	collectively	ADV
aji-174	158	19	influencing	influence	VERB
aji-174	158	20	chromatin	chromatin	NOUN
aji-174	158	21	accessibility	accessibility	NOUN
aji-174	158	22	and	and	CCONJ
aji-174	158	23	gene	gene	NOUN
aji-174	158	24	expression	expression	NOUN
aji-174	158	25	(	(	PUNCT
aji-174	158	26	nie	nie	PROPN
aji-174	158	27	et	et	PROPN
aji-174	158	28	al	al	PROPN
aji-174	158	29	.	.	PROPN
aji-174	158	30	,	,	PUNCT
aji-174	158	31	2024	2024	NUM
aji-174	158	32	)	)	PUNCT
aji-174	158	33	.	.	PUNCT
aji-174	159	1	the	the	DET
aji-174	159	2	most	most	ADV
aji-174	159	3	well	well	ADV
aji-174	159	4	-	-	PUNCT
aji-174	159	5	characterized	characterize	VERB
aji-174	159	6	modifications	modification	NOUN
aji-174	159	7	are	be	AUX
aji-174	159	8	:	:	PUNCT
aji-174	159	9	acetylation	acetylation	NOUN
aji-174	159	10	/	/	SYM
aji-174	159	11	deacetylation	deacetylation	NOUN
aji-174	159	12	:	:	PUNCT
aji-174	159	13	catalyzed	catalyze	VERB
aji-174	159	14	by	by	ADP
aji-174	159	15	histone	histone	NOUN
aji-174	159	16	acetyltransferases	acetyltransferase	NOUN
aji-174	159	17	(	(	PUNCT
aji-174	159	18	hats	hat	NOUN
aji-174	159	19	)	)	PUNCT
aji-174	159	20	and	and	CCONJ
aji-174	159	21	histone	histone	NOUN
aji-174	159	22	deacetylases	deacetylase	NOUN
aji-174	159	23	(	(	PUNCT
aji-174	159	24	hdacs	hdac	NOUN
aji-174	159	25	)	)	PUNCT
aji-174	159	26	,	,	PUNCT
aji-174	159	27	respectively	respectively	ADV
aji-174	159	28	.	.	PUNCT
aji-174	160	1	acetylation	acetylation	NOUN
aji-174	160	2	neutralizes	neutralize	VERB
aji-174	160	3	the	the	DET
aji-174	160	4	positive	positive	ADJ
aji-174	160	5	charge	charge	NOUN
aji-174	160	6	on	on	ADP
aji-174	160	7	lysine	lysine	NOUN
aji-174	160	8	residues	residue	NOUN
aji-174	160	9	,	,	PUNCT
aji-174	160	10	reducing	reduce	VERB
aji-174	160	11	the	the	DET
aji-174	160	12	affinity	affinity	NOUN
aji-174	160	13	between	between	ADP
aji-174	160	14	histones	histone	NOUN
aji-174	160	15	and	and	CCONJ
aji-174	160	16	the	the	DET
aji-174	160	17	negatively	negatively	ADV
aji-174	160	18	charged	charge	VERB
aji-174	160	19	dna	dna	PROPN
aji-174	160	20	backbone	backbone	NOUN
aji-174	160	21	.	.	PUNCT
aji-174	161	1	this	this	PRON
aji-174	161	2	results	result	VERB
aji-174	161	3	in	in	ADP
aji-174	161	4	a	a	DET
aji-174	161	5	more	more	ADV
aji-174	161	6	open	open	ADJ
aji-174	161	7	,	,	PUNCT
aji-174	161	8	transcriptionally	transcriptionally	ADV
aji-174	161	9	permissive	permissive	ADJ
aji-174	161	10	chromatin	chromatin	NOUN
aji-174	161	11	structure	structure	NOUN
aji-174	161	12	(	(	PUNCT
aji-174	161	13	euchromatin	euchromatin	PROPN
aji-174	161	14	)	)	PUNCT
aji-174	161	15	.	.	PUNCT
aji-174	162	1	deacetylation	deacetylation	NOUN
aji-174	162	2	has	have	VERB
aji-174	162	3	the	the	DET
aji-174	162	4	opposite	opposite	ADJ
aji-174	162	5	effect	effect	NOUN
aji-174	162	6	,	,	PUNCT
aji-174	162	7	promoting	promote	VERB
aji-174	162	8	chromatin	chromatin	NOUN
aji-174	162	9	condensation	condensation	NOUN
aji-174	162	10	and	and	CCONJ
aji-174	162	11	gene	gene	NOUN
aji-174	162	12	silencing	silence	VERB
aji-174	162	13	(	(	PUNCT
aji-174	162	14	heterochromatin	heterochromatin	NOUN
aji-174	162	15	)	)	PUNCT
aji-174	162	16	(	(	PUNCT
aji-174	162	17	chen	chen	PROPN
aji-174	162	18	et	et	PROPN
aji-174	162	19	al	al	PROPN
aji-174	162	20	.	.	PROPN
aji-174	162	21	,	,	PUNCT
aji-174	162	22	2024	2024	NUM
aji-174	162	23	)	)	PUNCT
aji-174	162	24	.	.	PUNCT
aji-174	163	1	methylation	methylation	NOUN
aji-174	163	2	:	:	PUNCT
aji-174	163	3	catalyzed	catalyze	VERB
aji-174	163	4	by	by	ADP
aji-174	163	5	histone	histone	NOUN
aji-174	163	6	methyltransferases	methyltransferase	NOUN
aji-174	163	7	(	(	PUNCT
aji-174	163	8	hmts	hmts	INTJ
aji-174	163	9	)	)	PUNCT
aji-174	163	10	and	and	CCONJ
aji-174	163	11	removed	remove	VERB
aji-174	163	12	by	by	ADP
aji-174	163	13	histone	histone	NOUN
aji-174	163	14	demethylases	demethylase	NOUN
aji-174	163	15	(	(	PUNCT
aji-174	163	16	hdms	hdms	ADV
aji-174	163	17	)	)	PUNCT
aji-174	163	18	.	.	PUNCT
aji-174	164	1	the	the	DET
aji-174	164	2	functional	functional	ADJ
aji-174	164	3	outcome	outcome	NOUN
aji-174	164	4	of	of	ADP
aji-174	164	5	methylation	methylation	NOUN
aji-174	164	6	is	be	AUX
aji-174	164	7	highly	highly	ADV
aji-174	164	8	contextdependent	contextdependent	ADJ
aji-174	164	9	,	,	PUNCT
aji-174	164	10	varying	vary	VERB
aji-174	164	11	by	by	ADP
aji-174	164	12	the	the	DET
aji-174	164	13	specific	specific	ADJ
aji-174	164	14	lysine	lysine	NOUN
aji-174	164	15	or	or	CCONJ
aji-174	164	16	arginine	arginine	NOUN
aji-174	164	17	residue	residue	NOUN
aji-174	164	18	modified	modify	VERB
aji-174	164	19	and	and	CCONJ
aji-174	164	20	the	the	DET
aji-174	164	21	degree	degree	NOUN
aji-174	164	22	of	of	ADP
aji-174	164	23	methylation	methylation	NOUN
aji-174	164	24	(	(	PUNCT
aji-174	164	25	mono-	mono-	X
aji-174	164	26	,	,	PUNCT
aji-174	164	27	di-	di-	PROPN
aji-174	164	28	,	,	PUNCT
aji-174	164	29	or	or	CCONJ
aji-174	164	30	tri	tri	ADJ
aji-174	164	31	-	-	NOUN
aji-174	164	32	methylation	methylation	NOUN
aji-174	164	33	)	)	PUNCT
aji-174	164	34	.	.	PUNCT
aji-174	165	1	for	for	ADP
aji-174	165	2	instance	instance	NOUN
aji-174	165	3	,	,	PUNCT
aji-174	165	4	trimethylation	trimethylation	NOUN
aji-174	165	5	of	of	ADP
aji-174	165	6	histone	histone	NOUN
aji-174	165	7	h3	h3	NOUN
aji-174	165	8	lysine	lysine	NOUN
aji-174	165	9	4	4	NUM
aji-174	165	10	(	(	PUNCT
aji-174	165	11	h3k4me3	h3k4me3	NOUN
aji-174	165	12	)	)	PUNCT
aji-174	165	13	is	be	AUX
aji-174	165	14	a	a	DET
aji-174	165	15	mark	mark	NOUN
aji-174	165	16	of	of	ADP
aji-174	165	17	active	active	ADJ
aji-174	165	18	promoters	promoter	NOUN
aji-174	165	19	,	,	PUNCT
aji-174	165	20	while	while	SCONJ
aji-174	165	21	trimethylation	trimethylation	NOUN
aji-174	165	22	of	of	ADP
aji-174	165	23	h3	h3	NOUN
aji-174	165	24	lysine	lysine	NOUN
aji-174	165	25	27	27	NUM
aji-174	165	26	(	(	PUNCT
aji-174	165	27	h3k27me3	h3k27me3	PROPN
aji-174	165	28	)	)	PUNCT
aji-174	165	29	is	be	AUX
aji-174	165	30	a	a	DET
aji-174	165	31	repressive	repressive	ADJ
aji-174	165	32	mark	mark	NOUN
aji-174	165	33	associated	associate	VERB
aji-174	165	34	with	with	ADP
aji-174	165	35	facultative	facultative	ADJ
aji-174	165	36	heterochromatin	heterochromatin	NOUN
aji-174	165	37	(	(	PUNCT
aji-174	165	38	chen	chen	PROPN
aji-174	165	39	et	et	PROPN
aji-174	165	40	al	al	PROPN
aji-174	165	41	.	.	PROPN
aji-174	165	42	,	,	PUNCT
aji-174	165	43	2024	2024	NUM
aji-174	165	44	)	)	PUNCT
aji-174	165	45	.	.	PUNCT
aji-174	166	1	the	the	DET
aji-174	166	2	"	"	PUNCT
aji-174	166	3	histone	histone	NOUN
aji-174	166	4	code	code	NOUN
aji-174	166	5	"	"	PUNCT
aji-174	166	6	hypothesis	hypothesis	NOUN
aji-174	166	7	posits	posit	NOUN
aji-174	166	8	that	that	SCONJ
aji-174	166	9	these	these	DET
aji-174	166	10	combinations	combination	NOUN
aji-174	166	11	of	of	ADP
aji-174	166	12	modifications	modification	NOUN
aji-174	166	13	act	act	VERB
aji-174	166	14	sequentially	sequentially	ADV
aji-174	166	15	or	or	CCONJ
aji-174	166	16	in	in	ADP
aji-174	166	17	concert	concert	NOUN
aji-174	166	18	to	to	PART
aji-174	166	19	form	form	VERB
aji-174	166	20	a	a	DET
aji-174	166	21	complex	complex	ADJ
aji-174	166	22	language	language	NOUN
aji-174	166	23	that	that	PRON
aji-174	166	24	dictates	dictate	VERB
aji-174	166	25	specific	specific	ADJ
aji-174	166	26	functional	functional	ADJ
aji-174	166	27	outcomes	outcome	NOUN
aji-174	166	28	for	for	ADP
aji-174	166	29	a	a	DET
aji-174	166	30	chromosomal	chromosomal	ADJ
aji-174	166	31	region	region	NOUN
aji-174	166	32	(	(	PUNCT
aji-174	166	33	ueberheide	ueberheide	INTJ
aji-174	166	34	et	et	PROPN
aji-174	166	35	al	al	PROPN
aji-174	166	36	.	.	PROPN
aji-174	166	37	,	,	PUNCT
aji-174	166	38	2024	2024	NUM
aji-174	166	39	)	)	PUNCT
aji-174	166	40	.	.	PUNCT
aji-174	167	1	in	in	ADP
aji-174	167	2	immune	immune	ADJ
aji-174	167	3	cells	cell	NOUN
aji-174	167	4	,	,	PUNCT
aji-174	167	5	activating	activate	VERB
aji-174	167	6	marks	mark	NOUN
aji-174	167	7	like	like	ADP
aji-174	167	8	h3k4me3	h3k4me3	NOUN
aji-174	167	9	ajibola	ajibola	PROPN
aji-174	167	10	and	and	CCONJ
aji-174	167	11	ayodele	ayodele	PROPN
aji-174	167	12	;	;	PUNCT
aji-174	167	13	asian	asian	PROPN
aji-174	167	14	j.	j.	PROPN
aji-174	167	15	immunol	immunol	PROPN
aji-174	167	16	.	.	PROPN
aji-174	167	17	,	,	PUNCT
aji-174	167	18	vol	vol	NOUN
aji-174	167	19	.	.	PROPN
aji-174	167	20	8	8	NUM
aji-174	167	21	,	,	PUNCT
aji-174	167	22	no	no	INTJ
aji-174	167	23	.	.	NOUN
aji-174	167	24	1	1	NUM
aji-174	167	25	,	,	PUNCT
aji-174	167	26	pp	pp	ADJ
aji-174	167	27	.	.	PUNCT
aji-174	168	1	230	230	NUM
aji-174	168	2	-	-	SYM
aji-174	168	3	241	241	NUM
aji-174	168	4	,	,	PUNCT
aji-174	168	5	2025	2025	NUM
aji-174	168	6	;	;	PUNCT
aji-174	168	7	article	article	NOUN
aji-174	168	8	no.aji.144830	no.aji.144830	NOUN
aji-174	168	9	233	233	NUM
aji-174	168	10	and	and	CCONJ
aji-174	168	11	h3k9ac	h3k9ac	NOUN
aji-174	168	12	are	be	AUX
aji-174	168	13	enriched	enrich	VERB
aji-174	168	14	at	at	ADP
aji-174	168	15	the	the	DET
aji-174	168	16	promoters	promoter	NOUN
aji-174	168	17	of	of	ADP
aji-174	168	18	highly	highly	ADV
aji-174	168	19	expressed	express	VERB
aji-174	168	20	cytokine	cytokine	NOUN
aji-174	168	21	genes	gene	NOUN
aji-174	168	22	(	(	PUNCT
aji-174	168	23	e.g.	e.g.	ADV
aji-174	168	24	,	,	PUNCT
aji-174	168	25	ifng	ifng	NOUN
aji-174	168	26	,	,	PUNCT
aji-174	168	27	il4	il4	NOUN
aji-174	168	28	,	,	PUNCT
aji-174	168	29	il17	il17	PROPN
aji-174	168	30	)	)	PUNCT
aji-174	168	31	,	,	PUNCT
aji-174	168	32	while	while	SCONJ
aji-174	168	33	repressive	repressive	ADJ
aji-174	168	34	marks	mark	NOUN
aji-174	168	35	like	like	ADP
aji-174	168	36	h3k27me3	h3k27me3	PROPN
aji-174	168	37	help	help	AUX
aji-174	168	38	silence	silence	VERB
aji-174	168	39	alternative	alternative	ADJ
aji-174	168	40	lineage	lineage	NOUN
aji-174	168	41	genes	gene	NOUN
aji-174	168	42	during	during	ADP
aji-174	168	43	t	t	NOUN
aji-174	168	44	-	-	PUNCT
aji-174	168	45	cell	cell	NOUN
aji-174	168	46	differentiation	differentiation	NOUN
aji-174	168	47	,	,	PUNCT
aji-174	168	48	ensuring	ensure	VERB
aji-174	168	49	stable	stable	ADJ
aji-174	168	50	effector	effector	NOUN
aji-174	168	51	cell	cell	NOUN
aji-174	168	52	identity	identity	NOUN
aji-174	168	53	(	(	PUNCT
aji-174	168	54	jay	jay	NOUN
aji-174	168	55	et	et	PROPN
aji-174	168	56	al	al	PROPN
aji-174	168	57	.	.	PROPN
aji-174	168	58	,	,	PUNCT
aji-174	168	59	2025	2025	NUM
aji-174	168	60	)	)	PUNCT
aji-174	168	61	.	.	PUNCT
aji-174	169	1	2.3	2.3	NUM
aji-174	169	2	non	non	ADJ
aji-174	169	3	-	-	ADJ
aji-174	169	4	coding	coding	ADJ
aji-174	169	5	rnas	rna	NOUN
aji-174	169	6	(	(	PUNCT
aji-174	169	7	ncrnas	ncrnas	PROPN
aji-174	169	8	)	)	PUNCT
aji-174	169	9	non	non	ADJ
aji-174	169	10	-	-	ADJ
aji-174	169	11	coding	coding	ADJ
aji-174	169	12	rnas	rna	NOUN
aji-174	169	13	represent	represent	VERB
aji-174	169	14	a	a	DET
aji-174	169	15	vast	vast	ADJ
aji-174	169	16	and	and	CCONJ
aji-174	169	17	diverse	diverse	ADJ
aji-174	169	18	class	class	NOUN
aji-174	169	19	of	of	ADP
aji-174	169	20	functional	functional	ADJ
aji-174	169	21	rna	rna	NOUN
aji-174	169	22	molecules	molecule	NOUN
aji-174	169	23	that	that	PRON
aji-174	169	24	are	be	AUX
aji-174	169	25	transcribed	transcribe	VERB
aji-174	169	26	from	from	ADP
aji-174	169	27	the	the	DET
aji-174	169	28	genome	genome	NOUN
aji-174	169	29	but	but	CCONJ
aji-174	169	30	not	not	PART
aji-174	169	31	translated	translate	VERB
aji-174	169	32	into	into	ADP
aji-174	169	33	proteins	protein	NOUN
aji-174	169	34	.	.	PUNCT
aji-174	170	1	they	they	PRON
aji-174	170	2	act	act	VERB
aji-174	170	3	as	as	ADP
aji-174	170	4	crucial	crucial	ADJ
aji-174	170	5	epigenetic	epigenetic	ADJ
aji-174	170	6	regulators	regulator	NOUN
aji-174	170	7	,	,	PUNCT
aji-174	170	8	primarily	primarily	ADV
aji-174	170	9	at	at	ADP
aji-174	170	10	the	the	DET
aji-174	170	11	post	post	ADJ
aji-174	170	12	-	-	ADJ
aji-174	170	13	transcriptional	transcriptional	ADJ
aji-174	170	14	level	level	NOUN
aji-174	170	15	.	.	PUNCT
aji-174	171	1	micrornas	microrna	NOUN
aji-174	171	2	(	(	PUNCT
aji-174	171	3	mirnas	mirna	NOUN
aji-174	171	4	):	):	PUNCT
aji-174	171	5	these	these	PRON
aji-174	171	6	are	be	AUX
aji-174	171	7	short	short	ADJ
aji-174	171	8	(	(	PUNCT
aji-174	171	9	~22	~22	INTJ
aji-174	171	10	nucleotides	nucleotide	NOUN
aji-174	171	11	)	)	PUNCT
aji-174	171	12	,	,	PUNCT
aji-174	171	13	single	single	ADJ
aji-174	171	14	-	-	PUNCT
aji-174	171	15	stranded	strand	VERB
aji-174	171	16	rnas	rna	NOUN
aji-174	171	17	that	that	PRON
aji-174	171	18	regulate	regulate	VERB
aji-174	171	19	gene	gene	NOUN
aji-174	171	20	expression	expression	NOUN
aji-174	171	21	by	by	ADP
aji-174	171	22	binding	bind	VERB
aji-174	171	23	to	to	ADP
aji-174	171	24	complementary	complementary	ADJ
aji-174	171	25	sequences	sequence	NOUN
aji-174	171	26	in	in	ADP
aji-174	171	27	the	the	DET
aji-174	171	28	3	3	NUM
aji-174	171	29	'	'	PART
aji-174	171	30	untranslated	untranslated	ADJ
aji-174	171	31	regions	region	NOUN
aji-174	171	32	(	(	PUNCT
aji-174	171	33	utrs	utrs	PROPN
aji-174	171	34	)	)	PUNCT
aji-174	171	35	of	of	ADP
aji-174	171	36	target	target	NOUN
aji-174	171	37	messenger	messenger	NOUN
aji-174	171	38	rnas	rna	NOUN
aji-174	171	39	(	(	PUNCT
aji-174	171	40	mrnas	mrnas	PROPN
aji-174	171	41	)	)	PUNCT
aji-174	171	42	.	.	PUNCT
aji-174	172	1	this	this	DET
aji-174	172	2	binding	bind	VERB
aji-174	172	3	typically	typically	ADV
aji-174	172	4	leads	lead	VERB
aji-174	172	5	to	to	ADP
aji-174	172	6	mrna	mrna	NOUN
aji-174	172	7	degradation	degradation	NOUN
aji-174	172	8	or	or	CCONJ
aji-174	172	9	translational	translational	ADJ
aji-174	172	10	repression	repression	NOUN
aji-174	172	11	.	.	PUNCT
aji-174	173	1	a	a	DET
aji-174	173	2	single	single	ADJ
aji-174	173	3	mirna	mirna	NOUN
aji-174	173	4	can	can	AUX
aji-174	173	5	target	target	VERB
aji-174	173	6	hundreds	hundred	NOUN
aji-174	173	7	of	of	ADP
aji-174	173	8	mrnas	mrna	NOUN
aji-174	173	9	,	,	PUNCT
aji-174	173	10	allowing	allow	VERB
aji-174	173	11	it	it	PRON
aji-174	173	12	to	to	ADP
aji-174	173	13	fine	fine	ADJ
aji-174	173	14	-	-	PUNCT
aji-174	173	15	tune	tune	NOUN
aji-174	173	16	entire	entire	ADJ
aji-174	173	17	genetic	genetic	ADJ
aji-174	173	18	networks	network	NOUN
aji-174	173	19	.	.	PUNCT
aji-174	174	1	in	in	ADP
aji-174	174	2	immunology	immunology	NOUN
aji-174	174	3	,	,	PUNCT
aji-174	174	4	mirnas	mirna	NOUN
aji-174	174	5	are	be	AUX
aji-174	174	6	indispensable	indispensable	ADJ
aji-174	174	7	regulators	regulator	NOUN
aji-174	174	8	of	of	ADP
aji-174	174	9	immune	immune	ADJ
aji-174	174	10	cell	cell	NOUN
aji-174	174	11	development	development	NOUN
aji-174	174	12	,	,	PUNCT
aji-174	174	13	proliferation	proliferation	NOUN
aji-174	174	14	,	,	PUNCT
aji-174	174	15	differentiation	differentiation	NOUN
aji-174	174	16	,	,	PUNCT
aji-174	174	17	and	and	CCONJ
aji-174	174	18	function	function	NOUN
aji-174	174	19	.	.	PUNCT
aji-174	175	1	for	for	ADP
aji-174	175	2	example	example	NOUN
aji-174	175	3	,	,	PUNCT
aji-174	175	4	mir-155	mir-155	X
aji-174	175	5	is	be	AUX
aji-174	175	6	a	a	DET
aji-174	175	7	proinflammatory	proinflammatory	ADJ
aji-174	175	8	mirna	mirna	NOUN
aji-174	175	9	that	that	PRON
aji-174	175	10	promotes	promote	VERB
aji-174	175	11	th1	th1	PROPN
aji-174	175	12	and	and	CCONJ
aji-174	175	13	th17	th17	PROPN
aji-174	175	14	responses	response	NOUN
aji-174	175	15	,	,	PUNCT
aji-174	175	16	while	while	SCONJ
aji-174	175	17	mir-146a	mir-146a	ADJ
aji-174	175	18	acts	act	NOUN
aji-174	175	19	as	as	ADP
aji-174	175	20	a	a	DET
aji-174	175	21	critical	critical	ADJ
aji-174	175	22	negative	negative	ADJ
aji-174	175	23	feedback	feedback	NOUN
aji-174	175	24	regulator	regulator	NOUN
aji-174	175	25	of	of	ADP
aji-174	175	26	nf	nf	ADJ
aji-174	175	27	-	-	PUNCT
aji-174	175	28	κb	κb	NOUN
aji-174	175	29	signaling	signaling	NOUN
aji-174	175	30	and	and	CCONJ
aji-174	175	31	is	be	AUX
aji-174	175	32	often	often	ADV
aji-174	175	33	dysregulated	dysregulate	VERB
aji-174	175	34	in	in	ADP
aji-174	175	35	autoimmunity	autoimmunity	NOUN
aji-174	175	36	(	(	PUNCT
aji-174	175	37	shaheen	shaheen	NOUN
aji-174	175	38	et	et	PROPN
aji-174	175	39	al	al	PROPN
aji-174	175	40	.	.	PROPN
aji-174	175	41	,	,	PUNCT
aji-174	175	42	2024	2024	NUM
aji-174	175	43	;	;	PUNCT
aji-174	175	44	mehta	mehta	PROPN
aji-174	175	45	et	et	PROPN
aji-174	175	46	al	al	PROPN
aji-174	175	47	.	.	PROPN
aji-174	175	48	,	,	PUNCT
aji-174	175	49	2025	2025	NUM
aji-174	175	50	)	)	PUNCT
aji-174	175	51	.	.	PUNCT
aji-174	176	1	long	long	ADJ
aji-174	176	2	non	non	ADJ
aji-174	176	3	-	-	ADJ
aji-174	176	4	coding	coding	ADJ
aji-174	176	5	rnas	rna	NOUN
aji-174	176	6	(	(	PUNCT
aji-174	176	7	lncrnas	lncrna	NOUN
aji-174	176	8	):	):	PUNCT
aji-174	176	9	these	these	PRON
aji-174	176	10	are	be	AUX
aji-174	176	11	transcripts	transcript	NOUN
aji-174	176	12	longer	long	ADJ
aji-174	176	13	than	than	ADP
aji-174	176	14	200	200	NUM
aji-174	176	15	nucleotides	nucleotide	NOUN
aji-174	176	16	with	with	ADP
aji-174	176	17	limited	limited	ADJ
aji-174	176	18	protein	protein	NOUN
aji-174	176	19	-	-	PUNCT
aji-174	176	20	coding	code	VERB
aji-174	176	21	potential	potential	NOUN
aji-174	176	22	.	.	PUNCT
aji-174	177	1	they	they	PRON
aji-174	177	2	exert	exert	VERB
aji-174	177	3	their	their	PRON
aji-174	177	4	regulatory	regulatory	ADJ
aji-174	177	5	functions	function	NOUN
aji-174	177	6	through	through	ADP
aji-174	177	7	a	a	DET
aji-174	177	8	variety	variety	NOUN
aji-174	177	9	of	of	ADP
aji-174	177	10	mechanisms	mechanism	NOUN
aji-174	177	11	:	:	PUNCT
aji-174	177	12	as	as	ADP
aji-174	177	13	scaffolds	scaffold	NOUN
aji-174	177	14	for	for	ADP
aji-174	177	15	chromatinmodifying	chromatinmodifying	NOUN
aji-174	177	16	complexes	complex	NOUN
aji-174	177	17	,	,	PUNCT
aji-174	177	18	guides	guide	NOUN
aji-174	177	19	for	for	ADP
aji-174	177	20	their	their	PRON
aji-174	177	21	localization	localization	NOUN
aji-174	177	22	to	to	ADP
aji-174	177	23	specific	specific	ADJ
aji-174	177	24	genomic	genomic	NOUN
aji-174	177	25	loci	locus	NOUN
aji-174	177	26	,	,	PUNCT
aji-174	177	27	decoys	decoy	NOUN
aji-174	177	28	for	for	ADP
aji-174	177	29	transcription	transcription	NOUN
aji-174	177	30	factors	factor	NOUN
aji-174	177	31	,	,	PUNCT
aji-174	177	32	or	or	CCONJ
aji-174	177	33	sponges	sponge	NOUN
aji-174	177	34	that	that	PRON
aji-174	177	35	sequester	sequester	NOUN
aji-174	177	36	mirnas	mirna	NOUN
aji-174	177	37	.	.	PUNCT
aji-174	178	1	the	the	DET
aji-174	178	2	lncrna	lncrna	NOUN
aji-174	178	3	malat1	malat1	PROPN
aji-174	178	4	,	,	PUNCT
aji-174	178	5	for	for	ADP
aji-174	178	6	instance	instance	NOUN
aji-174	178	7	,	,	PUNCT
aji-174	178	8	has	have	AUX
aji-174	178	9	been	be	AUX
aji-174	178	10	implicated	implicate	VERB
aji-174	178	11	in	in	ADP
aji-174	178	12	regulating	regulate	VERB
aji-174	178	13	alternative	alternative	ADJ
aji-174	178	14	splicing	splicing	NOUN
aji-174	178	15	and	and	CCONJ
aji-174	178	16	gene	gene	NOUN
aji-174	178	17	expression	expression	NOUN
aji-174	178	18	in	in	ADP
aji-174	178	19	immune	immune	ADJ
aji-174	178	20	cells	cell	NOUN
aji-174	178	21	,	,	PUNCT
aji-174	178	22	while	while	SCONJ
aji-174	178	23	others	other	NOUN
aji-174	178	24	like	like	ADP
aji-174	178	25	tmevpg1	tmevpg1	NOUN
aji-174	178	26	(	(	PUNCT
aji-174	178	27	nest	nest	NOUN
aji-174	178	28	)	)	PUNCT
aji-174	178	29	can	can	AUX
aji-174	178	30	influence	influence	VERB
aji-174	178	31	epigenetic	epigenetic	ADJ
aji-174	178	32	states	state	NOUN
aji-174	178	33	to	to	PART
aji-174	178	34	control	control	VERB
aji-174	178	35	interferon	interferon	ADJ
aji-174	178	36	-	-	PUNCT
aji-174	178	37	γ	γ	NOUN
aji-174	178	38	expression	expression	NOUN
aji-174	178	39	(	(	PUNCT
aji-174	178	40	antonazzo	antonazzo	PROPN
aji-174	178	41	et	et	PROPN
aji-174	178	42	al	al	PROPN
aji-174	178	43	.	.	PROPN
aji-174	178	44	,	,	PUNCT
aji-174	178	45	2024	2024	NUM
aji-174	178	46	)	)	PUNCT
aji-174	178	47	.	.	PUNCT
aji-174	179	1	these	these	DET
aji-174	179	2	three	three	NUM
aji-174	179	3	mechanisms	mechanism	NOUN
aji-174	179	4	do	do	AUX
aji-174	179	5	not	not	PART
aji-174	179	6	operate	operate	VERB
aji-174	179	7	in	in	ADP
aji-174	179	8	isolation	isolation	NOUN
aji-174	179	9	but	but	CCONJ
aji-174	179	10	form	form	VERB
aji-174	179	11	a	a	DET
aji-174	179	12	highly	highly	ADV
aji-174	179	13	integrated	integrate	VERB
aji-174	179	14	regulatory	regulatory	ADJ
aji-174	179	15	network	network	NOUN
aji-174	179	16	.	.	PUNCT
aji-174	180	1	dna	dna	PROPN
aji-174	180	2	methylation	methylation	NOUN
aji-174	180	3	can	can	AUX
aji-174	180	4	influence	influence	VERB
aji-174	180	5	histone	histone	NOUN
aji-174	180	6	modification	modification	NOUN
aji-174	180	7	patterns	pattern	NOUN
aji-174	180	8	,	,	PUNCT
aji-174	180	9	and	and	CCONJ
aji-174	180	10	both	both	PRON
aji-174	180	11	can	can	AUX
aji-174	180	12	be	be	AUX
aji-174	180	13	guided	guide	VERB
aji-174	180	14	by	by	ADP
aji-174	180	15	ncrnas	ncrna	NOUN
aji-174	180	16	.	.	PUNCT
aji-174	181	1	conversely	conversely	ADV
aji-174	181	2	,	,	PUNCT
aji-174	181	3	histone	histone	NOUN
aji-174	181	4	modifications	modification	NOUN
aji-174	181	5	can	can	AUX
aji-174	181	6	regulate	regulate	VERB
aji-174	181	7	the	the	DET
aji-174	181	8	expression	expression	NOUN
aji-174	181	9	of	of	ADP
aji-174	181	10	ncrnas	ncrna	NOUN
aji-174	181	11	.	.	PUNCT
aji-174	182	1	this	this	DET
aji-174	182	2	complex	complex	ADJ
aji-174	182	3	crosstalk	crosstalk	NOUN
aji-174	182	4	ensures	ensure	VERB
aji-174	182	5	precise	precise	ADJ
aji-174	182	6	spatiotemporal	spatiotemporal	ADJ
aji-174	182	7	control	control	NOUN
aji-174	182	8	of	of	ADP
aji-174	182	9	the	the	DET
aji-174	182	10	gene	gene	NOUN
aji-174	182	11	expression	expression	NOUN
aji-174	182	12	programs	program	NOUN
aji-174	182	13	that	that	PRON
aji-174	182	14	dictate	dictate	VERB
aji-174	182	15	immune	immune	ADJ
aji-174	182	16	cell	cell	NOUN
aji-174	182	17	identity	identity	NOUN
aji-174	182	18	and	and	CCONJ
aji-174	182	19	function	function	NOUN
aji-174	182	20	,	,	PUNCT
aji-174	182	21	and	and	CCONJ
aji-174	182	22	its	its	PRON
aji-174	182	23	disruption	disruption	NOUN
aji-174	182	24	lies	lie	VERB
aji-174	182	25	at	at	ADP
aji-174	182	26	the	the	DET
aji-174	182	27	heart	heart	NOUN
aji-174	182	28	of	of	ADP
aji-174	182	29	epigenetic	epigenetic	ADJ
aji-174	182	30	dysregulation	dysregulation	NOUN
aji-174	182	31	in	in	ADP
aji-174	182	32	disease	disease	NOUN
aji-174	182	33	(	(	PUNCT
aji-174	182	34	kong	kong	PROPN
aji-174	182	35	et	et	PROPN
aji-174	182	36	al	al	PROPN
aji-174	182	37	.	.	PROPN
aji-174	182	38	,	,	PUNCT
aji-174	182	39	2024	2024	NUM
aji-174	182	40	)	)	PUNCT
aji-174	182	41	.	.	PUNCT
aji-174	183	1	3	3	X
aji-174	183	2	.	.	X
aji-174	183	3	epigenetic	epigenetic	ADJ
aji-174	183	4	dysregulation	dysregulation	NOUN
aji-174	183	5	in	in	ADP
aji-174	183	6	specific	specific	ADJ
aji-174	183	7	immune	immune	NOUN
aji-174	183	8	-	-	PUNCT
aji-174	183	9	mediated	mediate	VERB
aji-174	183	10	diseases	disease	NOUN
aji-174	183	11	the	the	DET
aji-174	183	12	overarching	overarching	ADJ
aji-174	183	13	principles	principle	NOUN
aji-174	183	14	of	of	ADP
aji-174	183	15	epigenetic	epigenetic	ADJ
aji-174	183	16	regulation	regulation	NOUN
aji-174	183	17	become	become	VERB
aji-174	183	18	profoundly	profoundly	ADV
aji-174	183	19	altered	alter	VERB
aji-174	183	20	in	in	ADP
aji-174	183	21	immunemediated	immunemediate	VERB
aji-174	183	22	diseases	disease	NOUN
aji-174	183	23	.	.	PUNCT
aji-174	184	1	the	the	DET
aji-174	184	2	following	follow	VERB
aji-174	184	3	section	section	NOUN
aji-174	184	4	details	detail	VERB
aji-174	184	5	the	the	DET
aji-174	184	6	disease	disease	NOUN
aji-174	184	7	-	-	PUNCT
aji-174	184	8	specific	specific	ADJ
aji-174	184	9	epigenetic	epigenetic	ADJ
aji-174	184	10	landscapes	landscape	NOUN
aji-174	184	11	that	that	PRON
aji-174	184	12	contribute	contribute	VERB
aji-174	184	13	to	to	ADP
aji-174	184	14	pathogenesis	pathogenesis	NOUN
aji-174	184	15	,	,	PUNCT
aji-174	184	16	moving	move	VERB
aji-174	184	17	from	from	ADP
aji-174	184	18	systemic	systemic	ADJ
aji-174	184	19	autoimmunity	autoimmunity	NOUN
aji-174	184	20	to	to	ADP
aji-174	184	21	organ	organ	NOUN
aji-174	184	22	-	-	PUNCT
aji-174	184	23	specific	specific	ADJ
aji-174	184	24	disorders	disorder	NOUN
aji-174	184	25	.	.	PUNCT
aji-174	185	1	3.1	3.1	NUM
aji-174	185	2	systemic	systemic	ADJ
aji-174	185	3	lupus	lupus	PROPN
aji-174	185	4	erythematosus	erythematosus	NOUN
aji-174	185	5	(	(	PUNCT
aji-174	185	6	sle	sle	PROPN
aji-174	185	7	)	)	PUNCT
aji-174	185	8	sle	sle	PROPN
aji-174	185	9	is	be	AUX
aji-174	185	10	arguably	arguably	ADV
aji-174	185	11	the	the	DET
aji-174	185	12	best	well	ADV
aji-174	185	13	-	-	PUNCT
aji-174	185	14	studied	study	VERB
aji-174	185	15	autoimmune	autoimmune	ADJ
aji-174	185	16	disease	disease	NOUN
aji-174	185	17	from	from	ADP
aji-174	185	18	an	an	DET
aji-174	185	19	epigenetic	epigenetic	ADJ
aji-174	185	20	perspective	perspective	NOUN
aji-174	185	21	and	and	CCONJ
aji-174	185	22	is	be	AUX
aji-174	185	23	characterized	characterize	VERB
aji-174	185	24	by	by	ADP
aji-174	185	25	a	a	DET
aji-174	185	26	profound	profound	ADJ
aji-174	185	27	state	state	NOUN
aji-174	185	28	of	of	ADP
aji-174	185	29	global	global	ADJ
aji-174	185	30	dna	dna	PROPN
aji-174	185	31	hypomethylation	hypomethylation	NOUN
aji-174	185	32	in	in	ADP
aji-174	185	33	cd4	cd4	PROPN
aji-174	185	34	+	+	PROPN
aji-174	185	35	t	t	NOUN
aji-174	185	36	cells	cell	NOUN
aji-174	185	37	and	and	CCONJ
aji-174	185	38	other	other	ADJ
aji-174	185	39	immune	immune	ADJ
aji-174	185	40	cells	cell	NOUN
aji-174	185	41	.	.	PUNCT
aji-174	186	1	this	this	DET
aji-174	186	2	hypomethylation	hypomethylation	NOUN
aji-174	186	3	mirrors	mirror	VERB
aji-174	186	4	the	the	DET
aji-174	186	5	epigenetic	epigenetic	ADJ
aji-174	186	6	state	state	NOUN
aji-174	186	7	of	of	ADP
aji-174	186	8	activated	activate	VERB
aji-174	186	9	,	,	PUNCT
aji-174	186	10	proliferating	proliferate	VERB
aji-174	186	11	t	t	NOUN
aji-174	186	12	cells	cell	NOUN
aji-174	186	13	and	and	CCONJ
aji-174	186	14	leads	lead	VERB
aji-174	186	15	to	to	ADP
aji-174	186	16	the	the	DET
aji-174	186	17	overexpression	overexpression	NOUN
aji-174	186	18	of	of	ADP
aji-174	186	19	genes	gene	NOUN
aji-174	186	20	normally	normally	ADV
aji-174	186	21	silenced	silence	VERB
aji-174	186	22	in	in	ADP
aji-174	186	23	resting	rest	VERB
aji-174	186	24	lymphocytes	lymphocyte	NOUN
aji-174	186	25	,	,	PUNCT
aji-174	186	26	such	such	ADJ
aji-174	186	27	as	as	ADP
aji-174	186	28	perforin	perforin	NOUN
aji-174	186	29	(	(	PUNCT
aji-174	186	30	prf1	prf1	PROPN
aji-174	186	31	)	)	PUNCT
aji-174	186	32	,	,	PUNCT
aji-174	186	33	the	the	DET
aji-174	186	34	t	t	NOUN
aji-174	186	35	-	-	PUNCT
aji-174	186	36	cell	cell	NOUN
aji-174	186	37	adhesion	adhesion	NOUN
aji-174	186	38	molecule	molecule	NOUN
aji-174	186	39	itgal	itgal	NOUN
aji-174	186	40	(	(	PUNCT
aji-174	186	41	cd11a	cd11a	NOUN
aji-174	186	42	)	)	PUNCT
aji-174	186	43	,	,	PUNCT
aji-174	186	44	and	and	CCONJ
aji-174	186	45	the	the	DET
aji-174	186	46	co	co	ADJ
aji-174	186	47	-	-	ADJ
aji-174	186	48	stimulatory	stimulatory	ADJ
aji-174	186	49	molecule	molecule	NOUN
aji-174	186	50	tnfsf7	tnfsf7	NOUN
aji-174	186	51	(	(	PUNCT
aji-174	186	52	cd70	cd70	PROPN
aji-174	186	53	)	)	PUNCT
aji-174	186	54	(	(	PUNCT
aji-174	186	55	ribeiro	ribeiro	PROPN
aji-174	186	56	et	et	PROPN
aji-174	186	57	al	al	PROPN
aji-174	186	58	.	.	PROPN
aji-174	186	59	,	,	PUNCT
aji-174	186	60	2024	2024	NUM
aji-174	186	61	;	;	PUNCT
aji-174	186	62	araki	araki	PROPN
aji-174	186	63	&	&	CCONJ
aji-174	186	64	mimura	mimura	PROPN
aji-174	186	65	,	,	PUNCT
aji-174	186	66	2024	2024	NUM
aji-174	186	67	)	)	PUNCT
aji-174	186	68	.	.	PUNCT
aji-174	187	1	this	this	DET
aji-174	187	2	aberrant	aberrant	ADJ
aji-174	187	3	overexpression	overexpression	NOUN
aji-174	187	4	promotes	promote	VERB
aji-174	187	5	autoreactive	autoreactive	ADJ
aji-174	187	6	t	t	PROPN
aji-174	187	7	-	-	PUNCT
aji-174	187	8	cell	cell	NOUN
aji-174	187	9	help	help	NOUN
aji-174	187	10	to	to	ADP
aji-174	187	11	b	b	NOUN
aji-174	187	12	cells	cell	NOUN
aji-174	187	13	,	,	PUNCT
aji-174	187	14	driving	drive	VERB
aji-174	187	15	autoantibody	autoantibody	ADJ
aji-174	187	16	production	production	NOUN
aji-174	187	17	.	.	PUNCT
aji-174	188	1	mechanism	mechanism	NOUN
aji-174	188	2	of	of	ADP
aji-174	188	3	hypomethylation	hypomethylation	NOUN
aji-174	188	4	:	:	PUNCT
aji-174	188	5	the	the	DET
aji-174	188	6	root	root	NOUN
aji-174	188	7	cause	cause	NOUN
aji-174	188	8	involves	involve	VERB
aji-174	188	9	impaired	impaired	ADJ
aji-174	188	10	erk	erk	NOUN
aji-174	188	11	signaling	signal	VERB
aji-174	188	12	pathway	pathway	NOUN
aji-174	188	13	signaling	signal	VERB
aji-174	188	14	,	,	PUNCT
aji-174	188	15	leading	lead	VERB
aji-174	188	16	to	to	ADP
aji-174	188	17	reduced	reduce	VERB
aji-174	188	18	expression	expression	NOUN
aji-174	188	19	and	and	CCONJ
aji-174	188	20	translocation	translocation	NOUN
aji-174	188	21	of	of	ADP
aji-174	188	22	dnmt1	dnmt1	PROPN
aji-174	188	23	.	.	PUNCT
aji-174	189	1	this	this	DET
aji-174	189	2	results	result	VERB
aji-174	189	3	in	in	ADP
aji-174	189	4	passive	passive	ADJ
aji-174	189	5	demethylation	demethylation	NOUN
aji-174	189	6	during	during	ADP
aji-174	189	7	cell	cell	NOUN
aji-174	189	8	division	division	NOUN
aji-174	189	9	.	.	PUNCT
aji-174	190	1	furthermore	furthermore	ADV
aji-174	190	2	,	,	PUNCT
aji-174	190	3	oxidative	oxidative	ADJ
aji-174	190	4	stress	stress	NOUN
aji-174	190	5	and	and	CCONJ
aji-174	190	6	elevated	elevated	ADJ
aji-174	190	7	levels	level	NOUN
aji-174	190	8	of	of	ADP
aji-174	190	9	nitric	nitric	ADJ
aji-174	190	10	oxide	oxide	NOUN
aji-174	190	11	in	in	ADP
aji-174	190	12	sle	sle	PROPN
aji-174	190	13	patients	patient	NOUN
aji-174	190	14	can	can	AUX
aji-174	190	15	directly	directly	ADV
aji-174	190	16	inhibit	inhibit	VERB
aji-174	190	17	dnmt	dnmt	ADV
aji-174	190	18	enzymatic	enzymatic	ADJ
aji-174	190	19	activity	activity	NOUN
aji-174	190	20	(	(	PUNCT
aji-174	190	21	somers	somer	NOUN
aji-174	190	22	et	et	PROPN
aji-174	190	23	al	al	PROPN
aji-174	190	24	.	.	PROPN
aji-174	190	25	,	,	PUNCT
aji-174	190	26	2024	2024	NUM
aji-174	190	27	)	)	PUNCT
aji-174	190	28	.	.	PUNCT
aji-174	191	1	histone	histone	NOUN
aji-174	191	2	modifications	modification	NOUN
aji-174	191	3	:	:	PUNCT
aji-174	191	4	sle	sle	PROPN
aji-174	191	5	t	t	PROPN
aji-174	191	6	cells	cell	NOUN
aji-174	191	7	exhibit	exhibit	VERB
aji-174	191	8	a	a	DET
aji-174	191	9	shift	shift	NOUN
aji-174	191	10	towards	towards	ADP
aji-174	191	11	a	a	DET
aji-174	191	12	transcriptionally	transcriptionally	ADV
aji-174	191	13	permissive	permissive	ADJ
aji-174	191	14	chromatin	chromatin	NOUN
aji-174	191	15	state	state	NOUN
aji-174	191	16	.	.	PUNCT
aji-174	192	1	this	this	PRON
aji-174	192	2	is	be	AUX
aji-174	192	3	characterized	characterize	VERB
aji-174	192	4	by	by	ADP
aji-174	192	5	globally	globally	ADV
aji-174	192	6	decreased	decrease	VERB
aji-174	192	7	levels	level	NOUN
aji-174	192	8	of	of	ADP
aji-174	192	9	the	the	DET
aji-174	192	10	repressive	repressive	ADJ
aji-174	192	11	mark	mark	NOUN
aji-174	192	12	h3k27me3	h3k27me3	PROPN
aji-174	192	13	and	and	CCONJ
aji-174	192	14	increased	increase	VERB
aji-174	192	15	levels	level	NOUN
aji-174	192	16	of	of	ADP
aji-174	192	17	activating	activate	VERB
aji-174	192	18	marks	mark	NOUN
aji-174	192	19	like	like	ADP
aji-174	192	20	h3k18ac	h3k18ac	NOUN
aji-174	192	21	and	and	CCONJ
aji-174	192	22	h3k4me3	h3k4me3	X
aji-174	192	23	at	at	ADP
aji-174	192	24	the	the	DET
aji-174	192	25	promoters	promoter	NOUN
aji-174	192	26	of	of	ADP
aji-174	192	27	key	key	ADJ
aji-174	192	28	interferon	interferon	ADJ
aji-174	192	29	-	-	PUNCT
aji-174	192	30	stimulated	stimulate	VERB
aji-174	192	31	genes	gene	NOUN
aji-174	192	32	(	(	PUNCT
aji-174	192	33	isgs	isg	NOUN
aji-174	192	34	)	)	PUNCT
aji-174	192	35	and	and	CCONJ
aji-174	192	36	inflammatory	inflammatory	ADJ
aji-174	192	37	cytokines	cytokine	NOUN
aji-174	192	38	,	,	PUNCT
aji-174	192	39	amplifying	amplify	VERB
aji-174	192	40	the	the	DET
aji-174	192	41	type	type	NOUN
aji-174	192	42	i	i	PRON
aji-174	192	43	interferon	interferon	ADJ
aji-174	192	44	signature	signature	NOUN
aji-174	192	45	that	that	PRON
aji-174	192	46	is	be	AUX
aji-174	192	47	a	a	DET
aji-174	192	48	hallmark	hallmark	NOUN
aji-174	192	49	of	of	ADP
aji-174	192	50	sle	sle	PROPN
aji-174	192	51	(	(	PUNCT
aji-174	192	52	zhang	zhang	PROPN
aji-174	192	53	et	et	PROPN
aji-174	192	54	al	al	PROPN
aji-174	192	55	.	.	PROPN
aji-174	192	56	,	,	PUNCT
aji-174	192	57	2024	2024	NUM
aji-174	192	58	)	)	PUNCT
aji-174	192	59	.	.	PUNCT
aji-174	193	1	ajibola	ajibola	PROPN
aji-174	193	2	and	and	CCONJ
aji-174	193	3	ayodele	ayodele	PROPN
aji-174	193	4	;	;	PUNCT
aji-174	193	5	asian	asian	PROPN
aji-174	193	6	j.	j.	PROPN
aji-174	193	7	immunol	immunol	PROPN
aji-174	193	8	.	.	PROPN
aji-174	193	9	,	,	PUNCT
aji-174	193	10	vol	vol	NOUN
aji-174	193	11	.	.	PROPN
aji-174	193	12	8	8	NUM
aji-174	193	13	,	,	PUNCT
aji-174	193	14	no	no	INTJ
aji-174	193	15	.	.	NOUN
aji-174	193	16	1	1	NUM
aji-174	193	17	,	,	PUNCT
aji-174	193	18	pp	pp	ADJ
aji-174	193	19	.	.	PUNCT
aji-174	194	1	230	230	NUM
aji-174	194	2	-	-	SYM
aji-174	194	3	241	241	NUM
aji-174	194	4	,	,	PUNCT
aji-174	194	5	2025	2025	NUM
aji-174	194	6	;	;	PUNCT
aji-174	194	7	article	article	NOUN
aji-174	194	8	no.aji.144830	no.aji.144830	NOUN
aji-174	194	9	234	234	NUM
aji-174	194	10	ncrnas	ncrna	NOUN
aji-174	194	11	:	:	PUNCT
aji-174	194	12	a	a	DET
aji-174	194	13	distinct	distinct	ADJ
aji-174	194	14	mirna	mirna	NOUN
aji-174	194	15	signature	signature	NOUN
aji-174	194	16	is	be	AUX
aji-174	194	17	present	present	ADJ
aji-174	194	18	in	in	ADP
aji-174	194	19	sle	sle	PROPN
aji-174	194	20	patient	patient	NOUN
aji-174	194	21	blood	blood	NOUN
aji-174	194	22	and	and	CCONJ
aji-174	194	23	tissues	tissue	NOUN
aji-174	194	24	.	.	PUNCT
aji-174	195	1	mir-146a	mir-146a	ADJ
aji-174	195	2	,	,	PUNCT
aji-174	195	3	a	a	DET
aji-174	195	4	negative	negative	ADJ
aji-174	195	5	regulator	regulator	NOUN
aji-174	195	6	of	of	ADP
aji-174	195	7	the	the	DET
aji-174	195	8	interferon	interferon	ADJ
aji-174	195	9	pathway	pathway	NOUN
aji-174	195	10	,	,	PUNCT
aji-174	195	11	is	be	AUX
aji-174	195	12	under	under	ADP
aji-174	195	13	expressed	express	VERB
aji-174	195	14	,	,	PUNCT
aji-174	195	15	contributing	contribute	VERB
aji-174	195	16	to	to	ADP
aji-174	195	17	unchecked	unchecked	ADJ
aji-174	195	18	ifn	ifn	NOUN
aji-174	195	19	production	production	NOUN
aji-174	195	20	.	.	PUNCT
aji-174	196	1	conversely	conversely	ADV
aji-174	196	2	,	,	PUNCT
aji-174	196	3	mir-21	mir-21	PROPN
aji-174	196	4	and	and	CCONJ
aji-174	196	5	mir-148a	mir-148a	PROPN
aji-174	196	6	are	be	AUX
aji-174	196	7	overexpressed	overexpresse	VERB
aji-174	196	8	;	;	PUNCT
aji-174	196	9	they	they	PRON
aji-174	196	10	promote	promote	VERB
aji-174	196	11	autoimmunity	autoimmunity	NOUN
aji-174	196	12	by	by	ADP
aji-174	196	13	targeting	target	VERB
aji-174	196	14	dnmt1	dnmt1	NOUN
aji-174	196	15	,	,	PUNCT
aji-174	196	16	creating	create	VERB
aji-174	196	17	a	a	DET
aji-174	196	18	vicious	vicious	ADJ
aji-174	196	19	cycle	cycle	NOUN
aji-174	196	20	of	of	ADP
aji-174	196	21	dna	dna	PROPN
aji-174	196	22	hypomethylation	hypomethylation	NOUN
aji-174	196	23	,	,	PUNCT
aji-174	196	24	and	and	CCONJ
aji-174	196	25	by	by	ADP
aji-174	196	26	dampening	dampen	VERB
aji-174	196	27	negative	negative	ADJ
aji-174	196	28	regulatory	regulatory	ADJ
aji-174	196	29	pathways	pathway	NOUN
aji-174	196	30	(	(	PUNCT
aji-174	196	31	royo	royo	PROPN
aji-174	196	32	et	et	PROPN
aji-174	196	33	al	al	PROPN
aji-174	196	34	.	.	PROPN
aji-174	196	35	,	,	PUNCT
aji-174	196	36	2025	2025	NUM
aji-174	196	37	)	)	PUNCT
aji-174	196	38	.	.	PUNCT
aji-174	197	1	3.2	3.2	NUM
aji-174	197	2	rheumatoid	rheumatoid	NOUN
aji-174	197	3	arthritis	arthritis	NOUN
aji-174	197	4	(	(	PUNCT
aji-174	197	5	ra	ra	NOUN
aji-174	197	6	)	)	PUNCT
aji-174	197	7	in	in	ADP
aji-174	197	8	ra	ra	PROPN
aji-174	197	9	,	,	PUNCT
aji-174	197	10	epigenetic	epigenetic	ADJ
aji-174	197	11	dysregulation	dysregulation	NOUN
aji-174	197	12	is	be	AUX
aji-174	197	13	most	most	ADV
aji-174	197	14	prominently	prominently	ADV
aji-174	197	15	studied	study	VERB
aji-174	197	16	in	in	ADP
aji-174	197	17	the	the	DET
aji-174	197	18	hyperplastic	hyperplastic	ADJ
aji-174	197	19	,	,	PUNCT
aji-174	197	20	invasive	invasive	ADJ
aji-174	197	21	synovial	synovial	ADJ
aji-174	197	22	tissue	tissue	NOUN
aji-174	197	23	,	,	PUNCT
aji-174	197	24	particularly	particularly	ADV
aji-174	197	25	in	in	ADP
aji-174	197	26	fibroblast	fibroblast	ADJ
aji-174	197	27	-	-	PUNCT
aji-174	197	28	like	like	ADJ
aji-174	197	29	synoviocytes	synoviocyte	NOUN
aji-174	197	30	(	(	PUNCT
aji-174	197	31	fls	fls	PROPN
aji-174	197	32	)	)	PUNCT
aji-174	197	33	,	,	PUNCT
aji-174	197	34	which	which	PRON
aji-174	197	35	develop	develop	VERB
aji-174	197	36	an	an	DET
aji-174	197	37	aggressive	aggressive	ADJ
aji-174	197	38	,	,	PUNCT
aji-174	197	39	"	"	PUNCT
aji-174	197	40	transformed	transform	VERB
aji-174	197	41	-	-	PUNCT
aji-174	197	42	like	like	ADJ
aji-174	197	43	"	"	PUNCT
aji-174	197	44	phenotype	phenotype	NOUN
aji-174	197	45	that	that	PRON
aji-174	197	46	drives	drive	VERB
aji-174	197	47	joint	joint	ADJ
aji-174	197	48	destruction	destruction	NOUN
aji-174	197	49	.	.	PUNCT
aji-174	198	1	dna	dna	PROPN
aji-174	198	2	methylation	methylation	NOUN
aji-174	198	3	:	:	PUNCT
aji-174	198	4	ra	ra	PROPN
aji-174	198	5	-	-	PUNCT
aji-174	198	6	fls	fls	PROPN
aji-174	198	7	exhibit	exhibit	VERB
aji-174	198	8	a	a	DET
aji-174	198	9	unique	unique	ADJ
aji-174	198	10	and	and	CCONJ
aji-174	198	11	stable	stable	ADJ
aji-174	198	12	"	"	PUNCT
aji-174	198	13	methylation	methylation	NOUN
aji-174	198	14	signature	signature	NOUN
aji-174	198	15	"	"	PUNCT
aji-174	198	16	that	that	PRON
aji-174	198	17	distinguishes	distinguish	VERB
aji-174	198	18	them	they	PRON
aji-174	198	19	from	from	ADP
aji-174	198	20	osteoarthritis	osteoarthritis	NOUN
aji-174	198	21	fls	fls	PROPN
aji-174	198	22	and	and	CCONJ
aji-174	198	23	is	be	AUX
aji-174	198	24	present	present	ADJ
aji-174	198	25	even	even	ADV
aji-174	198	26	in	in	ADP
aji-174	198	27	early	early	ADJ
aji-174	198	28	disease	disease	NOUN
aji-174	198	29	.	.	PUNCT
aji-174	199	1	key	key	ADJ
aji-174	199	2	changes	change	NOUN
aji-174	199	3	include	include	VERB
aji-174	199	4	:	:	PUNCT
aji-174	199	5	hypomethylation	hypomethylation	NOUN
aji-174	199	6	of	of	ADP
aji-174	199	7	genes	gene	NOUN
aji-174	199	8	encoding	encode	VERB
aji-174	199	9	matrixdegrading	matrixdegrading	ADJ
aji-174	199	10	enzymes	enzyme	NOUN
aji-174	199	11	(	(	PUNCT
aji-174	199	12	mmp3	mmp3	NOUN
aji-174	199	13	,	,	PUNCT
aji-174	199	14	mmp9	mmp9	PROPN
aji-174	199	15	)	)	PUNCT
aji-174	199	16	,	,	PUNCT
aji-174	199	17	chemokines	chemokine	NOUN
aji-174	199	18	(	(	PUNCT
aji-174	199	19	cxcl12	cxcl12	ADJ
aji-174	199	20	)	)	PUNCT
aji-174	199	21	,	,	PUNCT
aji-174	199	22	and	and	CCONJ
aji-174	199	23	critical	critical	ADJ
aji-174	199	24	signaling	signal	VERB
aji-174	199	25	molecules	molecule	NOUN
aji-174	199	26	(	(	PUNCT
aji-174	199	27	stat3	stat3	NOUN
aji-174	199	28	,	,	PUNCT
aji-174	199	29	irf5	irf5	PROPN
aji-174	199	30	)	)	PUNCT
aji-174	199	31	,	,	PUNCT
aji-174	199	32	leading	lead	VERB
aji-174	199	33	to	to	ADP
aji-174	199	34	their	their	PRON
aji-174	199	35	overexpression	overexpression	NOUN
aji-174	199	36	and	and	CCONJ
aji-174	199	37	promoting	promote	VERB
aji-174	199	38	inflammation	inflammation	NOUN
aji-174	199	39	,	,	PUNCT
aji-174	199	40	angiogenesis	angiogenesis	NOUN
aji-174	199	41	,	,	PUNCT
aji-174	199	42	and	and	CCONJ
aji-174	199	43	tissue	tissue	NOUN
aji-174	199	44	invasion	invasion	NOUN
aji-174	199	45	(	(	PUNCT
aji-174	199	46	prideaux	prideaux	INTJ
aji-174	199	47	et	et	PROPN
aji-174	199	48	al	al	PROPN
aji-174	199	49	.	.	PROPN
aji-174	199	50	,	,	PUNCT
aji-174	199	51	2024	2024	NUM
aji-174	199	52	)	)	PUNCT
aji-174	199	53	.	.	PUNCT
aji-174	200	1	hypermethylation	hypermethylation	NOUN
aji-174	200	2	of	of	ADP
aji-174	200	3	genes	gene	NOUN
aji-174	200	4	that	that	PRON
aji-174	200	5	normally	normally	ADV
aji-174	200	6	promote	promote	VERB
aji-174	200	7	apoptosis	apoptosis	NOUN
aji-174	200	8	or	or	CCONJ
aji-174	200	9	cell	cell	NOUN
aji-174	200	10	cycle	cycle	NOUN
aji-174	200	11	arrest	arrest	NOUN
aji-174	200	12	,	,	PUNCT
aji-174	200	13	such	such	ADJ
aji-174	200	14	as	as	ADP
aji-174	200	15	tnfrsf25	tnfrsf25	NOUN
aji-174	200	16	(	(	PUNCT
aji-174	200	17	dr3	dr3	PROPN
aji-174	200	18	)	)	PUNCT
aji-174	200	19	and	and	CCONJ
aji-174	200	20	bcl2l11	bcl2l11	NOUN
aji-174	200	21	(	(	PUNCT
aji-174	200	22	bim	bim	NOUN
aji-174	200	23	)	)	PUNCT
aji-174	200	24	,	,	PUNCT
aji-174	200	25	conferring	confer	VERB
aji-174	200	26	resistance	resistance	NOUN
aji-174	200	27	to	to	ADP
aji-174	200	28	cell	cell	NOUN
aji-174	200	29	death	death	NOUN
aji-174	200	30	and	and	CCONJ
aji-174	200	31	contributing	contribute	VERB
aji-174	200	32	to	to	ADP
aji-174	200	33	synovial	synovial	ADJ
aji-174	200	34	hyperplasia	hyperplasia	NOUN
aji-174	200	35	(	(	PUNCT
aji-174	200	36	svendsen	svendsen	PROPN
aji-174	200	37	et	et	PROPN
aji-174	200	38	al	al	PROPN
aji-174	200	39	.	.	PROPN
aji-174	200	40	,	,	PUNCT
aji-174	200	41	2025	2025	NUM
aji-174	200	42	)	)	PUNCT
aji-174	200	43	.	.	PUNCT
aji-174	201	1	histone	histone	NOUN
aji-174	201	2	modifications	modification	NOUN
aji-174	201	3	:	:	PUNCT
aji-174	201	4	the	the	DET
aji-174	201	5	balance	balance	NOUN
aji-174	201	6	of	of	ADP
aji-174	201	7	hat	hat	NOUN
aji-174	201	8	/	/	SYM
aji-174	201	9	hdac	hdac	NOUN
aji-174	201	10	activity	activity	NOUN
aji-174	201	11	is	be	AUX
aji-174	201	12	skewed	skew	VERB
aji-174	201	13	in	in	ADP
aji-174	201	14	ra	ra	PROPN
aji-174	201	15	.	.	PUNCT
aji-174	202	1	while	while	SCONJ
aji-174	202	2	some	some	DET
aji-174	202	3	hdacs	hdac	NOUN
aji-174	202	4	are	be	AUX
aji-174	202	5	downregulated	downregulate	VERB
aji-174	202	6	,	,	PUNCT
aji-174	202	7	class	class	NOUN
aji-174	202	8	i	i	PROPN
aji-174	202	9	and	and	CCONJ
aji-174	202	10	ii	ii	PROPN
aji-174	202	11	hdac	hdac	NOUN
aji-174	202	12	activity	activity	NOUN
aji-174	202	13	is	be	AUX
aji-174	202	14	generally	generally	ADV
aji-174	202	15	increased	increase	VERB
aji-174	202	16	in	in	ADP
aji-174	202	17	ra	ra	PROPN
aji-174	202	18	synovium	synovium	NOUN
aji-174	202	19	,	,	PUNCT
aji-174	202	20	contributing	contribute	VERB
aji-174	202	21	to	to	ADP
aji-174	202	22	the	the	DET
aji-174	202	23	suppression	suppression	NOUN
aji-174	202	24	of	of	ADP
aji-174	202	25	antiinflammatory	antiinflammatory	NOUN
aji-174	202	26	genes	gene	NOUN
aji-174	202	27	.	.	PUNCT
aji-174	203	1	conversely	conversely	ADV
aji-174	203	2	,	,	PUNCT
aji-174	203	3	hat	hat	NOUN
aji-174	203	4	activity	activity	NOUN
aji-174	203	5	is	be	AUX
aji-174	203	6	also	also	ADV
aji-174	203	7	elevated	elevate	VERB
aji-174	203	8	,	,	PUNCT
aji-174	203	9	promoting	promote	VERB
aji-174	203	10	the	the	DET
aji-174	203	11	expression	expression	NOUN
aji-174	203	12	of	of	ADP
aji-174	203	13	proinflammatory	proinflammatory	ADJ
aji-174	203	14	genes	gene	NOUN
aji-174	203	15	like	like	ADP
aji-174	203	16	il6	il6	NOUN
aji-174	203	17	and	and	CCONJ
aji-174	203	18	tnf	tnf	PROPN
aji-174	203	19	(	(	PUNCT
aji-174	203	20	enayati	enayati	PROPN
aji-174	203	21	et	et	PROPN
aji-174	203	22	al	al	PROPN
aji-174	203	23	.	.	PROPN
aji-174	203	24	,	,	PUNCT
aji-174	203	25	2024	2024	NUM
aji-174	203	26	)	)	PUNCT
aji-174	203	27	.	.	PUNCT
aji-174	204	1	ncrnas	ncrna	NOUN
aji-174	204	2	:	:	PUNCT
aji-174	204	3	mir-155	mir-155	PROPN
aji-174	204	4	is	be	AUX
aji-174	204	5	highly	highly	ADV
aji-174	204	6	expressed	express	VERB
aji-174	204	7	in	in	ADP
aji-174	204	8	ra	ra	PROPN
aji-174	204	9	synovial	synovial	ADJ
aji-174	204	10	fluid	fluid	NOUN
aji-174	204	11	and	and	CCONJ
aji-174	204	12	tissue	tissue	NOUN
aji-174	204	13	,	,	PUNCT
aji-174	204	14	where	where	SCONJ
aji-174	204	15	it	it	PRON
aji-174	204	16	promotes	promote	VERB
aji-174	204	17	macrophage	macrophage	ADJ
aji-174	204	18	activation	activation	NOUN
aji-174	204	19	and	and	CCONJ
aji-174	204	20	th17	th17	PROPN
aji-174	204	21	cell	cell	NOUN
aji-174	204	22	differentiation	differentiation	NOUN
aji-174	204	23	.	.	PUNCT
aji-174	205	1	mir-146a	mir-146a	PROPN
aji-174	205	2	is	be	AUX
aji-174	205	3	also	also	ADV
aji-174	205	4	upregulated	upregulate	VERB
aji-174	205	5	but	but	CCONJ
aji-174	205	6	may	may	AUX
aji-174	205	7	act	act	VERB
aji-174	205	8	in	in	ADP
aji-174	205	9	a	a	DET
aji-174	205	10	feedback	feedback	NOUN
aji-174	205	11	inhibitory	inhibitory	ADJ
aji-174	205	12	role	role	NOUN
aji-174	205	13	that	that	PRON
aji-174	205	14	is	be	AUX
aji-174	205	15	ultimately	ultimately	ADV
aji-174	205	16	insufficient	insufficient	ADJ
aji-174	205	17	to	to	PART
aji-174	205	18	control	control	VERB
aji-174	205	19	inflammation	inflammation	NOUN
aji-174	205	20	.	.	PUNCT
aji-174	206	1	mir-124a	mir-124a	PROPN
aji-174	206	2	is	be	AUX
aji-174	206	3	significantly	significantly	ADV
aji-174	206	4	downregulated	downregulate	VERB
aji-174	206	5	,	,	PUNCT
aji-174	206	6	leading	lead	VERB
aji-174	206	7	to	to	ADP
aji-174	206	8	increased	increase	VERB
aji-174	206	9	activation	activation	NOUN
aji-174	206	10	of	of	ADP
aji-174	206	11	the	the	DET
aji-174	206	12	monocyte	monocyte	NOUN
aji-174	206	13	chemoattractant	chemoattractant	NOUN
aji-174	206	14	ccl2	ccl2	NOUN
aji-174	206	15	(	(	PUNCT
aji-174	206	16	seyedi	seyedi	PROPN
aji-174	206	17	et	et	PROPN
aji-174	206	18	al	al	PROPN
aji-174	206	19	.	.	PROPN
aji-174	206	20	,	,	PUNCT
aji-174	206	21	2024	2024	NUM
aji-174	206	22	)	)	PUNCT
aji-174	206	23	.	.	PUNCT
aji-174	207	1	3.3	3.3	NUM
aji-174	207	2	multiple	multiple	ADJ
aji-174	207	3	sclerosis	sclerosis	NOUN
aji-174	207	4	(	(	PUNCT
aji-174	207	5	ms	ms	NOUN
aji-174	207	6	)	)	PUNCT
aji-174	207	7	epigenetic	epigenetic	ADJ
aji-174	207	8	mechanisms	mechanism	NOUN
aji-174	207	9	in	in	ADP
aji-174	207	10	ms	ms	PROPN
aji-174	207	11	are	be	AUX
aji-174	207	12	critical	critical	ADJ
aji-174	207	13	for	for	ADP
aji-174	207	14	determining	determine	VERB
aji-174	207	15	the	the	DET
aji-174	207	16	fate	fate	NOUN
aji-174	207	17	of	of	ADP
aji-174	207	18	t	t	NOUN
aji-174	207	19	cells	cell	NOUN
aji-174	207	20	,	,	PUNCT
aji-174	207	21	pushing	push	VERB
aji-174	207	22	differentiation	differentiation	NOUN
aji-174	207	23	towards	towards	ADP
aji-174	207	24	pro	pro	ADJ
aji-174	207	25	-	-	ADJ
aji-174	207	26	inflammatory	inflammatory	ADJ
aji-174	207	27	th1	th1	NOUN
aji-174	207	28	and	and	CCONJ
aji-174	207	29	th17	th17	PROPN
aji-174	207	30	lineages	lineage	NOUN
aji-174	207	31	and	and	CCONJ
aji-174	207	32	away	away	ADV
aji-174	207	33	from	from	ADP
aji-174	207	34	immunoregulatory	immunoregulatory	ADJ
aji-174	207	35	tregs	treg	NOUN
aji-174	207	36	.	.	PUNCT
aji-174	208	1	dna	dna	PROPN
aji-174	208	2	methylation	methylation	NOUN
aji-174	208	3	:	:	PUNCT
aji-174	208	4	genome	genome	NOUN
aji-174	208	5	-	-	PUNCT
aji-174	208	6	wide	wide	ADJ
aji-174	208	7	studies	study	NOUN
aji-174	208	8	reveal	reveal	VERB
aji-174	208	9	significant	significant	ADJ
aji-174	208	10	differences	difference	NOUN
aji-174	208	11	in	in	ADP
aji-174	208	12	dna	dna	PROPN
aji-174	208	13	methylation	methylation	NOUN
aji-174	208	14	patterns	pattern	NOUN
aji-174	208	15	in	in	ADP
aji-174	208	16	cd4	cd4	PROPN
aji-174	208	17	+	+	PROPN
aji-174	208	18	t	t	NOUN
aji-174	208	19	cells	cell	NOUN
aji-174	208	20	,	,	PUNCT
aji-174	208	21	cd8	cd8	PROPN
aji-174	208	22	+	+	PROPN
aji-174	208	23	t	t	NOUN
aji-174	208	24	cells	cell	NOUN
aji-174	208	25	,	,	PUNCT
aji-174	208	26	and	and	CCONJ
aji-174	208	27	b	b	X
aji-174	208	28	cells	cell	NOUN
aji-174	208	29	of	of	ADP
aji-174	208	30	ms	ms	NOUN
aji-174	208	31	patients	patient	NOUN
aji-174	208	32	compared	compare	VERB
aji-174	208	33	to	to	ADP
aji-174	208	34	controls	control	NOUN
aji-174	208	35	.	.	PUNCT
aji-174	209	1	intriguingly	intriguingly	ADV
aji-174	209	2	,	,	PUNCT
aji-174	209	3	the	the	DET
aji-174	209	4	strongest	strong	ADJ
aji-174	209	5	ms	ms	ADJ
aji-174	209	6	-	-	PUNCT
aji-174	209	7	associated	associate	VERB
aji-174	209	8	genetic	genetic	ADJ
aji-174	209	9	risk	risk	NOUN
aji-174	209	10	variant	variant	NOUN
aji-174	209	11	,	,	PUNCT
aji-174	209	12	hla	hla	NOUN
aji-174	209	13	-	-	PUNCT
aji-174	209	14	drb1	drb1	PROPN
aji-174	209	15	,	,	PUNCT
aji-174	209	16	also	also	ADV
aji-174	209	17	displays	display	VERB
aji-174	209	18	msspecific	msspecific	ADJ
aji-174	209	19	methylation	methylation	NOUN
aji-174	209	20	patterns	pattern	NOUN
aji-174	209	21	,	,	PUNCT
aji-174	209	22	suggesting	suggest	VERB
aji-174	209	23	a	a	DET
aji-174	209	24	complex	complex	ADJ
aji-174	209	25	gene	gene	NOUN
aji-174	209	26	-	-	PUNCT
aji-174	209	27	environment	environment	NOUN
aji-174	209	28	interaction	interaction	NOUN
aji-174	209	29	where	where	SCONJ
aji-174	209	30	epigenetics	epigenetic	NOUN
aji-174	209	31	modulates	modulate	VERB
aji-174	209	32	the	the	DET
aji-174	209	33	effect	effect	NOUN
aji-174	209	34	of	of	ADP
aji-174	209	35	the	the	DET
aji-174	209	36	primary	primary	ADJ
aji-174	209	37	genetic	genetic	ADJ
aji-174	209	38	risk	risk	NOUN
aji-174	209	39	factor	factor	NOUN
aji-174	209	40	(	(	PUNCT
aji-174	209	41	elbahrawi	elbahrawi	NOUN
aji-174	209	42	et	et	PROPN
aji-174	209	43	al	al	PROPN
aji-174	209	44	.	.	PROPN
aji-174	209	45	,	,	PUNCT
aji-174	209	46	2024	2024	NUM
aji-174	209	47	)	)	PUNCT
aji-174	209	48	.	.	PUNCT
aji-174	210	1	key	key	ADJ
aji-174	210	2	hypomethylated	hypomethylated	ADJ
aji-174	210	3	loci	locus	NOUN
aji-174	210	4	are	be	AUX
aji-174	210	5	associated	associate	VERB
aji-174	210	6	with	with	ADP
aji-174	210	7	t	t	NOUN
aji-174	210	8	-	-	PUNCT
aji-174	210	9	cell	cell	NOUN
aji-174	210	10	activation	activation	NOUN
aji-174	210	11	and	and	CCONJ
aji-174	210	12	adhesion	adhesion	NOUN
aji-174	210	13	pathways	pathway	NOUN
aji-174	210	14	.	.	PUNCT
aji-174	211	1	histone	histone	NOUN
aji-174	211	2	modifications	modification	NOUN
aji-174	211	3	:	:	PUNCT
aji-174	211	4	hdacs	hdac	NOUN
aji-174	211	5	and	and	CCONJ
aji-174	211	6	sirtuins	sirtuin	NOUN
aji-174	211	7	(	(	PUNCT
aji-174	211	8	sirt1	sirt1	NOUN
aji-174	211	9	,	,	PUNCT
aji-174	211	10	a	a	DET
aji-174	211	11	class	class	NOUN
aji-174	211	12	iii	iii	PROPN
aji-174	211	13	hdac	hdac	PROPN
aji-174	211	14	)	)	PUNCT
aji-174	211	15	are	be	AUX
aji-174	211	16	key	key	ADJ
aji-174	211	17	regulators	regulator	NOUN
aji-174	211	18	of	of	ADP
aji-174	211	19	t	t	PROPN
aji-174	211	20	-	-	PUNCT
aji-174	211	21	cell	cell	NOUN
aji-174	211	22	plasticity	plasticity	NOUN
aji-174	211	23	in	in	ADP
aji-174	211	24	ms	ms	PROPN
aji-174	211	25	.	.	PROPN
aji-174	211	26	sirt1	sirt1	PROPN
aji-174	211	27	deficiency	deficiency	NOUN
aji-174	211	28	has	have	AUX
aji-174	211	29	been	be	AUX
aji-174	211	30	linked	link	VERB
aji-174	211	31	to	to	ADP
aji-174	211	32	hyperacetylation	hyperacetylation	NOUN
aji-174	211	33	of	of	ADP
aji-174	211	34	the	the	DET
aji-174	211	35	transcription	transcription	NOUN
aji-174	211	36	factor	factor	NOUN
aji-174	211	37	foxo1	foxo1	NOUN
aji-174	211	38	,	,	PUNCT
aji-174	211	39	impairing	impair	VERB
aji-174	211	40	treg	treg	PROPN
aji-174	211	41	function	function	NOUN
aji-174	211	42	and	and	CCONJ
aji-174	211	43	promoting	promote	VERB
aji-174	211	44	a	a	DET
aji-174	211	45	pro	pro	ADJ
aji-174	211	46	-	-	ADJ
aji-174	211	47	inflammatory	inflammatory	ADJ
aji-174	211	48	t	t	NOUN
aji-174	211	49	-	-	PUNCT
aji-174	211	50	cell	cell	NOUN
aji-174	211	51	state	state	NOUN
aji-174	211	52	.	.	PUNCT
aji-174	212	1	furthermore	furthermore	ADV
aji-174	212	2	,	,	PUNCT
aji-174	212	3	inhibitors	inhibitor	NOUN
aji-174	212	4	of	of	ADP
aji-174	212	5	hdacs	hdac	NOUN
aji-174	212	6	have	have	AUX
aji-174	212	7	been	be	AUX
aji-174	212	8	shown	show	VERB
aji-174	212	9	to	to	PART
aji-174	212	10	ameliorate	ameliorate	VERB
aji-174	212	11	disease	disease	NOUN
aji-174	212	12	in	in	ADP
aji-174	212	13	experimental	experimental	ADJ
aji-174	212	14	autoimmune	autoimmune	ADJ
aji-174	212	15	encephalomyelitis	encephalomyelitis	NOUN
aji-174	212	16	(	(	PUNCT
aji-174	212	17	eae	eae	PROPN
aji-174	212	18	)	)	PUNCT
aji-174	212	19	,	,	PUNCT
aji-174	212	20	the	the	DET
aji-174	212	21	mouse	mouse	NOUN
aji-174	212	22	model	model	NOUN
aji-174	212	23	of	of	ADP
aji-174	212	24	ms	ms	PROPN
aji-174	212	25	,	,	PUNCT
aji-174	212	26	by	by	ADP
aji-174	212	27	promoting	promote	VERB
aji-174	212	28	treg	treg	PROPN
aji-174	212	29	development	development	PROPN
aji-174	212	30	(	(	PUNCT
aji-174	212	31	xie	xie	PROPN
aji-174	212	32	et	et	PROPN
aji-174	212	33	al	al	PROPN
aji-174	212	34	.	.	PROPN
aji-174	212	35	,	,	PUNCT
aji-174	212	36	2025	2025	NUM
aji-174	212	37	)	)	PUNCT
aji-174	212	38	.	.	PUNCT
aji-174	213	1	ncrnas	ncrna	NOUN
aji-174	213	2	:	:	PUNCT
aji-174	213	3	circulating	circulate	VERB
aji-174	213	4	mirnas	mirna	NOUN
aji-174	213	5	serve	serve	VERB
aji-174	213	6	as	as	ADP
aji-174	213	7	promising	promise	VERB
aji-174	213	8	biomarkers	biomarker	NOUN
aji-174	213	9	.	.	PUNCT
aji-174	214	1	mir-326	mir-326	NOUN
aji-174	214	2	expression	expression	NOUN
aji-174	214	3	correlates	correlate	VERB
aji-174	214	4	with	with	ADP
aji-174	214	5	disease	disease	NOUN
aji-174	214	6	severity	severity	NOUN
aji-174	214	7	and	and	CCONJ
aji-174	214	8	promotes	promote	VERB
aji-174	214	9	th17	th17	PROPN
aji-174	214	10	differentiation	differentiation	NOUN
aji-174	214	11	.	.	PUNCT
aji-174	215	1	mir-17	mir-17	NOUN
aji-174	215	2	-	-	SYM
aji-174	215	3	92	92	NUM
aji-174	215	4	cluster	cluster	NOUN
aji-174	215	5	members	member	NOUN
aji-174	215	6	are	be	AUX
aji-174	215	7	dysregulated	dysregulate	VERB
aji-174	215	8	,	,	PUNCT
aji-174	215	9	impacting	impact	VERB
aji-174	215	10	t	t	NOUN
aji-174	215	11	-	-	PUNCT
aji-174	215	12	cell	cell	NOUN
aji-174	215	13	proliferation	proliferation	NOUN
aji-174	215	14	.	.	PUNCT
aji-174	216	1	serum	serum	NOUN
aji-174	216	2	levels	level	NOUN
aji-174	216	3	of	of	ADP
aji-174	216	4	mir-155	mir-155	NOUN
aji-174	216	5	and	and	CCONJ
aji-174	216	6	mir-301a	mir-301a	NOUN
aji-174	216	7	are	be	AUX
aji-174	216	8	also	also	ADV
aji-174	216	9	elevated	elevate	VERB
aji-174	216	10	and	and	CCONJ
aji-174	216	11	associated	associate	VERB
aji-174	216	12	with	with	ADP
aji-174	216	13	active	active	ADJ
aji-174	216	14	disease	disease	NOUN
aji-174	216	15	(	(	PUNCT
aji-174	216	16	xie	xie	PROPN
aji-174	216	17	et	et	PROPN
aji-174	216	18	al	al	PROPN
aji-174	216	19	.	.	PROPN
aji-174	216	20	,	,	PUNCT
aji-174	216	21	2025	2025	NUM
aji-174	216	22	)	)	PUNCT
aji-174	216	23	3.4	3.4	NUM
aji-174	216	24	inflammatory	inflammatory	ADJ
aji-174	216	25	bowel	bowel	NOUN
aji-174	216	26	disease	disease	NOUN
aji-174	216	27	(	(	PUNCT
aji-174	216	28	ibd	ibd	PROPN
aji-174	216	29	:	:	PUNCT
aji-174	216	30	crohn	crohn	PROPN
aji-174	216	31	's	's	PART
aji-174	216	32	disease	disease	NOUN
aji-174	216	33	&	&	CCONJ
aji-174	216	34	ulcerative	ulcerative	ADJ
aji-174	216	35	colitis	colitis	NOUN
aji-174	216	36	)	)	PUNCT
aji-174	216	37	the	the	DET
aji-174	216	38	intestinal	intestinal	ADJ
aji-174	216	39	epithelium	epithelium	NOUN
aji-174	216	40	and	and	CCONJ
aji-174	216	41	mucosal	mucosal	ADJ
aji-174	216	42	immune	immune	ADJ
aji-174	216	43	system	system	NOUN
aji-174	216	44	in	in	ADP
aji-174	216	45	ibd	ibd	NOUN
aji-174	216	46	patients	patient	NOUN
aji-174	216	47	display	display	VERB
aji-174	216	48	widespread	widespread	ADJ
aji-174	216	49	epigenetic	epigenetic	ADJ
aji-174	216	50	alterations	alteration	NOUN
aji-174	216	51	induced	induce	VERB
aji-174	216	52	by	by	ADP
aji-174	216	53	the	the	DET
aji-174	216	54	luminal	luminal	ADJ
aji-174	216	55	environment	environment	NOUN
aji-174	216	56	(	(	PUNCT
aji-174	216	57	microbiome	microbiome	NOUN
aji-174	216	58	,	,	PUNCT
aji-174	216	59	nutrients	nutrient	NOUN
aji-174	216	60	)	)	PUNCT
aji-174	216	61	.	.	PUNCT
aji-174	217	1	dna	dna	PROPN
aji-174	217	2	methylation	methylation	NOUN
aji-174	217	3	:	:	PUNCT
aji-174	217	4	studies	study	NOUN
aji-174	217	5	on	on	ADP
aji-174	217	6	intestinal	intestinal	ADJ
aji-174	217	7	mucosal	mucosal	NOUN
aji-174	217	8	biopsies	biopsy	NOUN
aji-174	217	9	reveal	reveal	VERB
aji-174	217	10	hundreds	hundred	NOUN
aji-174	217	11	of	of	ADP
aji-174	217	12	differentially	differentially	ADV
aji-174	217	13	methylated	methylate	VERB
aji-174	217	14	regions	region	NOUN
aji-174	217	15	.	.	PUNCT
aji-174	218	1	crohn	crohn	PROPN
aji-174	218	2	's	's	PART
aji-174	218	3	disease	disease	NOUN
aji-174	218	4	is	be	AUX
aji-174	218	5	often	often	ADV
aji-174	218	6	associated	associate	VERB
aji-174	218	7	with	with	ADP
aji-174	218	8	hypermethylation	hypermethylation	NOUN
aji-174	218	9	and	and	CCONJ
aji-174	218	10	silencing	silencing	NOUN
aji-174	218	11	of	of	ADP
aji-174	218	12	the	the	DET
aji-174	218	13	socs1	socs1	PROPN
aji-174	218	14	gene	gene	NOUN
aji-174	218	15	,	,	PUNCT
aji-174	218	16	a	a	DET
aji-174	218	17	negative	negative	ADJ
aji-174	218	18	regulator	regulator	NOUN
aji-174	218	19	of	of	ADP
aji-174	218	20	cytokine	cytokine	ADJ
aji-174	218	21	signaling	signal	VERB
aji-174	218	22	,	,	PUNCT
aji-174	218	23	leading	lead	VERB
aji-174	218	24	to	to	ADP
aji-174	218	25	enhanced	enhance	VERB
aji-174	218	26	jak	jak	PROPN
aji-174	218	27	/	/	SYM
aji-174	218	28	stat	stat	PROPN
aji-174	218	29	signaling	signal	VERB
aji-174	218	30	.	.	PUNCT
aji-174	219	1	in	in	ADP
aji-174	219	2	ulcerative	ulcerative	ADJ
aji-174	219	3	colitis	colitis	NOUN
aji-174	219	4	,	,	PUNCT
aji-174	219	5	the	the	DET
aji-174	219	6	tnf	tnf	PROPN
aji-174	219	7	gene	gene	NOUN
aji-174	219	8	promoter	promoter	NOUN
aji-174	219	9	is	be	AUX
aji-174	219	10	often	often	ADV
aji-174	219	11	hypomethylated	hypomethylate	VERB
aji-174	219	12	,	,	PUNCT
aji-174	219	13	contributing	contribute	VERB
aji-174	219	14	to	to	ADP
aji-174	219	15	its	its	PRON
aji-174	219	16	excessive	excessive	ADJ
aji-174	219	17	production	production	NOUN
aji-174	219	18	(	(	PUNCT
aji-174	219	19	mahurkar‐joshi	mahurkar‐joshi	PROPN
aji-174	219	20	et	et	PROPN
aji-174	219	21	al	al	PROPN
aji-174	219	22	.	.	PROPN
aji-174	219	23	,	,	PUNCT
aji-174	219	24	2025	2025	NUM
aji-174	219	25	)	)	PUNCT
aji-174	219	26	.	.	PUNCT
aji-174	220	1	ajibola	ajibola	PROPN
aji-174	220	2	and	and	CCONJ
aji-174	220	3	ayodele	ayodele	PROPN
aji-174	220	4	;	;	PUNCT
aji-174	220	5	asian	asian	PROPN
aji-174	220	6	j.	j.	PROPN
aji-174	220	7	immunol	immunol	PROPN
aji-174	220	8	.	.	PROPN
aji-174	220	9	,	,	PUNCT
aji-174	220	10	vol	vol	NOUN
aji-174	220	11	.	.	PROPN
aji-174	220	12	8	8	NUM
aji-174	220	13	,	,	PUNCT
aji-174	220	14	no	no	INTJ
aji-174	220	15	.	.	NOUN
aji-174	220	16	1	1	NUM
aji-174	220	17	,	,	PUNCT
aji-174	220	18	pp	pp	ADJ
aji-174	220	19	.	.	PUNCT
aji-174	221	1	230	230	NUM
aji-174	221	2	-	-	SYM
aji-174	221	3	241	241	NUM
aji-174	221	4	,	,	PUNCT
aji-174	221	5	2025	2025	NUM
aji-174	221	6	;	;	PUNCT
aji-174	221	7	article	article	NOUN
aji-174	221	8	no.aji.144830	no.aji.144830	NOUN
aji-174	221	9	235	235	NUM
aji-174	221	10	table	table	NOUN
aji-174	221	11	1	1	NUM
aji-174	221	12	.	.	PUNCT
aji-174	221	13	summary	summary	NOUN
aji-174	221	14	of	of	ADP
aji-174	221	15	key	key	ADJ
aji-174	221	16	epigenetic	epigenetic	ADJ
aji-174	221	17	alterations	alteration	NOUN
aji-174	221	18	in	in	ADP
aji-174	221	19	major	major	ADJ
aji-174	221	20	immune	immune	NOUN
aji-174	221	21	-	-	PUNCT
aji-174	221	22	mediated	mediate	VERB
aji-174	221	23	diseases	disease	NOUN
aji-174	221	24	disease	disease	NOUN
aji-174	221	25	cell	cell	NOUN
aji-174	221	26	type/	type/	NUM
aji-174	221	27	tissue	tissue	NOUN
aji-174	221	28	dna	dna	PROPN
aji-174	221	29	methylation	methylation	NOUN
aji-174	221	30	changes	change	VERB
aji-174	221	31	histone	histone	NOUN
aji-174	221	32	modifications	modification	NOUN
aji-174	221	33	key	key	ADJ
aji-174	221	34	ncrnas	ncrna	NOUN
aji-174	221	35	involved	involve	VERB
aji-174	221	36	sle	sle	PROPN
aji-174	221	37	cd4	cd4	PROPN
aji-174	221	38	+	+	PROPN
aji-174	221	39	t	t	PROPN
aji-174	221	40	cells	cell	NOUN
aji-174	221	41	global	global	ADJ
aji-174	221	42	hypomethylation	hypomethylation	NOUN
aji-174	221	43	;	;	PUNCT
aji-174	221	44	hypomethylation	hypomethylation	NOUN
aji-174	221	45	of	of	ADP
aji-174	221	46	cd11a	cd11a	NOUN
aji-174	221	47	,	,	PUNCT
aji-174	221	48	cd70	cd70	PROPN
aji-174	221	49	increased	increase	VERB
aji-174	221	50	h3	h3	NOUN
aji-174	221	51	/	/	SYM
aji-174	221	52	h4	h4	PROPN
aji-174	221	53	acetylation	acetylation	NOUN
aji-174	221	54	↓	↓	PROPN
aji-174	221	55	mir-146a	mir-146a	PROPN
aji-174	221	56	,	,	PUNCT
aji-174	221	57	↑	↑	PROPN
aji-174	221	58	mir-21	mir-21	PROPN
aji-174	221	59	,	,	PUNCT
aji-174	221	60	↑	↑	PROPN
aji-174	221	61	mir-155	mir-155	VERB
aji-174	221	62	ra	ra	PROPN
aji-174	221	63	synovial	synovial	PROPN
aji-174	221	64	fls	fls	PROPN
aji-174	221	65	hypomethylation	hypomethylation	NOUN
aji-174	221	66	of	of	ADP
aji-174	221	67	cxcl12	cxcl12	ADJ
aji-174	221	68	,	,	PUNCT
aji-174	221	69	il6	il6	NOUN
aji-174	221	70	;	;	PUNCT
aji-174	221	71	hypermethylation	hypermethylation	NOUN
aji-174	221	72	of	of	ADP
aji-174	221	73	dr3	dr3	PROPN
aji-174	221	74	,	,	PUNCT
aji-174	221	75	bim	bim	NOUN
aji-174	221	76	increased	increase	VERB
aji-174	221	77	hdac	hdac	NOUN
aji-174	221	78	activity	activity	PROPN
aji-174	221	79	↑	↑	PROPN
aji-174	221	80	mir-155	mir-155	PROPN
aji-174	221	81	,	,	PUNCT
aji-174	221	82	↑	↑	PROPN
aji-174	221	83	mir-203	mir-203	PROPN
aji-174	221	84	,	,	PUNCT
aji-174	221	85	↑	↑	PROPN
aji-174	221	86	mir-124a	mir-124a	PART
aji-174	221	87	ms	ms	PROPN
aji-174	221	88	cd4	cd4	PROPN
aji-174	221	89	+	+	PROPN
aji-174	221	90	t	t	NOUN
aji-174	221	91	cells	cell	NOUN
aji-174	221	92	,	,	PUNCT
aji-174	221	93	pbmcs	pbmcs	ADJ
aji-174	221	94	differential	differential	ADJ
aji-174	221	95	methylation	methylation	NOUN
aji-174	221	96	at	at	ADP
aji-174	221	97	hla	hla	PROPN
aji-174	221	98	&	&	CCONJ
aji-174	221	99	non	non	PROPN
aji-174	221	100	-	-	ADJ
aji-174	221	101	hla	hla	ADJ
aji-174	221	102	loci	loci	NOUN
aji-174	221	103	altered	alter	VERB
aji-174	221	104	hdac	hdac	PROPN
aji-174	221	105	/	/	SYM
aji-174	221	106	sirt	sirt	PROPN
aji-174	221	107	expression	expression	NOUN
aji-174	221	108	↑	↑	PROPN
aji-174	221	109	mir-326	mir-326	PROPN
aji-174	221	110	,	,	PUNCT
aji-174	221	111	↑	↑	PROPN
aji-174	221	112	mir-155	mir-155	PROPN
aji-174	221	113	,	,	PUNCT
aji-174	221	114	↓	↓	PROPN
aji-174	221	115	mir-17	mir-17	PROPN
aji-174	221	116	-	-	SYM
aji-174	221	117	92	92	NUM
aji-174	221	118	ibd	ibd	NOUN
aji-174	221	119	intestinal	intestinal	ADJ
aji-174	221	120	mucosa	mucosa	NOUN
aji-174	221	121	hypermethylation	hypermethylation	NOUN
aji-174	221	122	of	of	ADP
aji-174	221	123	socs1	socs1	PROPN
aji-174	221	124	(	(	PUNCT
aji-174	221	125	crohn	crohn	PROPN
aji-174	221	126	's	's	PART
aji-174	221	127	)	)	PUNCT
aji-174	221	128	;	;	PUNCT
aji-174	221	129	hypomethylation	hypomethylation	NOUN
aji-174	221	130	of	of	ADP
aji-174	221	131	tnf	tnf	PROPN
aji-174	221	132	altered	alter	VERB
aji-174	221	133	hat	hat	PROPN
aji-174	221	134	/	/	SYM
aji-174	221	135	hdac	hdac	NOUN
aji-174	221	136	balance	balance	PROPN
aji-174	221	137	↑	↑	PROPN
aji-174	221	138	mir-21	mir-21	PROPN
aji-174	221	139	,	,	PUNCT
aji-174	221	140	↑	↑	PROPN
aji-174	221	141	mir-29	mir-29	PROPN
aji-174	221	142	,	,	PUNCT
aji-174	221	143	mir-196	mir-196	PROPN
aji-174	221	144	dysregulation	dysregulation	NOUN
aji-174	221	145	histone	histone	NOUN
aji-174	221	146	modifications	modification	NOUN
aji-174	221	147	:	:	PUNCT
aji-174	221	148	butyrate	butyrate	NOUN
aji-174	221	149	,	,	PUNCT
aji-174	221	150	a	a	DET
aji-174	221	151	short	short	ADJ
aji-174	221	152	-	-	PUNCT
aji-174	221	153	chain	chain	NOUN
aji-174	221	154	fatty	fatty	NOUN
aji-174	221	155	acid	acid	NOUN
aji-174	221	156	produced	produce	VERB
aji-174	221	157	by	by	ADP
aji-174	221	158	commensal	commensal	ADJ
aji-174	221	159	gut	gut	NOUN
aji-174	221	160	bacteria	bacteria	NOUN
aji-174	221	161	,	,	PUNCT
aji-174	221	162	is	be	AUX
aji-174	221	163	a	a	DET
aji-174	221	164	natural	natural	ADJ
aji-174	221	165	hdac	hdac	NOUN
aji-174	221	166	inhibitor	inhibitor	NOUN
aji-174	221	167	.	.	PUNCT
aji-174	222	1	a	a	DET
aji-174	222	2	deficiency	deficiency	NOUN
aji-174	222	3	in	in	ADP
aji-174	222	4	butyrate	butyrate	ADJ
aji-174	222	5	production	production	NOUN
aji-174	222	6	or	or	CCONJ
aji-174	222	7	sensing	sense	VERB
aji-174	222	8	in	in	ADP
aji-174	222	9	ibd	ibd	PROPN
aji-174	222	10	leads	lead	VERB
aji-174	222	11	to	to	ADP
aji-174	222	12	increased	increase	VERB
aji-174	222	13	hdac	hdac	NOUN
aji-174	222	14	activity	activity	NOUN
aji-174	222	15	,	,	PUNCT
aji-174	222	16	repressing	repress	VERB
aji-174	222	17	the	the	DET
aji-174	222	18	expression	expression	NOUN
aji-174	222	19	of	of	ADP
aji-174	222	20	anti	anti	ADJ
aji-174	222	21	-	-	ADJ
aji-174	222	22	inflammatory	inflammatory	ADJ
aji-174	222	23	genes	gene	NOUN
aji-174	222	24	and	and	CCONJ
aji-174	222	25	genes	gene	NOUN
aji-174	222	26	involved	involve	VERB
aji-174	222	27	in	in	ADP
aji-174	222	28	epithelial	epithelial	ADJ
aji-174	222	29	barrier	barrier	NOUN
aji-174	222	30	integrity	integrity	NOUN
aji-174	222	31	.	.	PUNCT
aji-174	223	1	this	this	DET
aji-174	223	2	links	link	VERB
aji-174	223	3	the	the	DET
aji-174	223	4	environmental	environmental	ADJ
aji-174	223	5	factor	factor	NOUN
aji-174	223	6	(	(	PUNCT
aji-174	223	7	microbiome	microbiome	NOUN
aji-174	223	8	)	)	PUNCT
aji-174	223	9	directly	directly	ADV
aji-174	223	10	to	to	ADP
aji-174	223	11	epigenetic	epigenetic	ADJ
aji-174	223	12	dysregulation	dysregulation	NOUN
aji-174	223	13	(	(	PUNCT
aji-174	223	14	li	li	PROPN
aji-174	223	15	et	et	PROPN
aji-174	223	16	al	al	PROPN
aji-174	223	17	.	.	PROPN
aji-174	223	18	,	,	PUNCT
aji-174	223	19	2025	2025	NUM
aji-174	223	20	)	)	PUNCT
aji-174	223	21	ncrnas	ncrna	NOUN
aji-174	223	22	:	:	PUNCT
aji-174	223	23	mir-21	mir-21	PROPN
aji-174	223	24	is	be	AUX
aji-174	223	25	upregulated	upregulate	VERB
aji-174	223	26	in	in	ADP
aji-174	223	27	ibd	ibd	PROPN
aji-174	223	28	mucosa	mucosa	NOUN
aji-174	223	29	and	and	CCONJ
aji-174	223	30	promotes	promote	VERB
aji-174	223	31	intestinal	intestinal	ADJ
aji-174	223	32	inflammation	inflammation	NOUN
aji-174	223	33	by	by	ADP
aji-174	223	34	targeting	target	VERB
aji-174	223	35	pdcd4	pdcd4	PROPN
aji-174	223	36	,	,	PUNCT
aji-174	223	37	a	a	DET
aji-174	223	38	suppressor	suppressor	NOUN
aji-174	223	39	of	of	ADP
aji-174	223	40	il-10	il-10	DET
aji-174	223	41	expression	expression	NOUN
aji-174	223	42	.	.	PUNCT
aji-174	224	1	mir-29	mir-29	PUNCT
aji-174	224	2	is	be	AUX
aji-174	224	3	also	also	ADV
aji-174	224	4	overexpressed	overexpresse	VERB
aji-174	224	5	and	and	CCONJ
aji-174	224	6	targets	target	VERB
aji-174	224	7	key	key	ADJ
aji-174	224	8	molecules	molecule	NOUN
aji-174	224	9	essential	essential	ADJ
aji-174	224	10	for	for	ADP
aji-174	224	11	intestinal	intestinal	ADJ
aji-174	224	12	barrier	barrier	NOUN
aji-174	224	13	function	function	NOUN
aji-174	224	14	.	.	PUNCT
aji-174	225	1	the	the	DET
aji-174	225	2	let-7	let-7	PUNCT
aji-174	225	3	family	family	NOUN
aji-174	225	4	mirnas	mirna	NOUN
aji-174	225	5	are	be	AUX
aji-174	225	6	involved	involve	VERB
aji-174	225	7	in	in	ADP
aji-174	225	8	regulating	regulate	VERB
aji-174	225	9	il-13	il-13	ADV
aji-174	225	10	-	-	PUNCT
aji-174	225	11	mediated	mediate	VERB
aji-174	225	12	inflammation	inflammation	NOUN
aji-174	225	13	(	(	PUNCT
aji-174	225	14	goodarzi	goodarzi	NOUN
aji-174	225	15	et	et	PROPN
aji-174	225	16	al	al	PROPN
aji-174	225	17	.	.	PROPN
aji-174	225	18	,	,	PUNCT
aji-174	225	19	2025	2025	NUM
aji-174	225	20	)	)	PUNCT
aji-174	225	21	.	.	PUNCT
aji-174	226	1	4	4	X
aji-174	226	2	.	.	X
aji-174	226	3	environmental	environmental	ADJ
aji-174	226	4	triggers	trigger	NOUN
aji-174	226	5	and	and	CCONJ
aji-174	226	6	epigenetic	epigenetic	ADJ
aji-174	226	7	modification	modification	NOUN
aji-174	226	8	the	the	DET
aji-174	226	9	compelling	compelling	ADJ
aji-174	226	10	evidence	evidence	NOUN
aji-174	226	11	for	for	ADP
aji-174	226	12	epigenetic	epigenetic	ADJ
aji-174	226	13	dysregulation	dysregulation	NOUN
aji-174	226	14	in	in	ADP
aji-174	226	15	immune	immune	NOUN
aji-174	226	16	-	-	PUNCT
aji-174	226	17	mediated	mediate	VERB
aji-174	226	18	diseases	disease	NOUN
aji-174	226	19	raises	raise	VERB
aji-174	226	20	a	a	DET
aji-174	226	21	critical	critical	ADJ
aji-174	226	22	question	question	NOUN
aji-174	226	23	:	:	PUNCT
aji-174	226	24	what	what	PRON
aji-174	226	25	initiates	initiate	VERB
aji-174	226	26	these	these	DET
aji-174	226	27	changes	change	NOUN
aji-174	226	28	?	?	PUNCT
aji-174	227	1	environmental	environmental	ADJ
aji-174	227	2	factors	factor	NOUN
aji-174	227	3	are	be	AUX
aji-174	227	4	the	the	DET
aji-174	227	5	primary	primary	ADJ
aji-174	227	6	architects	architect	NOUN
aji-174	227	7	,	,	PUNCT
aji-174	227	8	acting	act	VERB
aji-174	227	9	upon	upon	SCONJ
aji-174	227	10	a	a	DET
aji-174	227	11	genetically	genetically	ADV
aji-174	227	12	susceptible	susceptible	ADJ
aji-174	227	13	background	background	NOUN
aji-174	227	14	to	to	PART
aji-174	227	15	instigate	instigate	VERB
aji-174	227	16	pathogenic	pathogenic	ADJ
aji-174	227	17	epigenetic	epigenetic	ADJ
aji-174	227	18	reprogramming	reprogramming	NOUN
aji-174	227	19	.	.	PUNCT
aji-174	228	1	these	these	DET
aji-174	228	2	exposures	exposure	NOUN
aji-174	228	3	can	can	AUX
aji-174	228	4	induce	induce	VERB
aji-174	228	5	stable	stable	ADJ
aji-174	228	6	alterations	alteration	NOUN
aji-174	228	7	to	to	ADP
aji-174	228	8	the	the	DET
aji-174	228	9	epigenome	epigenome	NOUN
aji-174	228	10	of	of	ADP
aji-174	228	11	immune	immune	ADJ
aji-174	228	12	cells	cell	NOUN
aji-174	228	13	and	and	CCONJ
aji-174	228	14	tissue	tissue	NOUN
aji-174	228	15	-	-	PUNCT
aji-174	228	16	resident	resident	NOUN
aji-174	228	17	cells	cell	NOUN
aji-174	228	18	,	,	PUNCT
aji-174	228	19	effectively	effectively	ADV
aji-174	228	20	"	"	PUNCT
aji-174	228	21	embedding	embed	VERB
aji-174	228	22	"	"	PUNCT
aji-174	228	23	the	the	DET
aji-174	228	24	memory	memory	NOUN
aji-174	228	25	of	of	ADP
aji-174	228	26	a	a	DET
aji-174	228	27	environmental	environmental	ADJ
aji-174	228	28	insult	insult	NOUN
aji-174	228	29	and	and	CCONJ
aji-174	228	30	lowering	lower	VERB
aji-174	228	31	the	the	DET
aji-174	228	32	threshold	threshold	NOUN
aji-174	228	33	for	for	ADP
aji-174	228	34	autoimmune	autoimmune	ADJ
aji-174	228	35	activation	activation	NOUN
aji-174	228	36	.	.	PUNCT
aji-174	229	1	the	the	DET
aji-174	229	2	timing	timing	NOUN
aji-174	229	3	of	of	ADP
aji-174	229	4	exposure	exposure	NOUN
aji-174	229	5	(	(	PUNCT
aji-174	229	6	e.g.	e.g.	ADV
aji-174	229	7	,	,	PUNCT
aji-174	229	8	in	in	ADP
aji-174	229	9	utero	utero	ADJ
aji-174	229	10	,	,	PUNCT
aji-174	229	11	during	during	ADP
aji-174	229	12	adolescence	adolescence	NOUN
aji-174	229	13	)	)	PUNCT
aji-174	229	14	can	can	AUX
aji-174	229	15	be	be	AUX
aji-174	229	16	as	as	ADV
aji-174	229	17	critical	critical	ADJ
aji-174	229	18	as	as	ADP
aji-174	229	19	the	the	DET
aji-174	229	20	exposure	exposure	NOUN
aji-174	229	21	itself	itself	PRON
aji-174	229	22	due	due	ADP
aji-174	229	23	to	to	ADP
aji-174	229	24	periods	period	NOUN
aji-174	229	25	of	of	ADP
aji-174	229	26	heightened	heightened	ADJ
aji-174	229	27	epigenetic	epigenetic	ADJ
aji-174	229	28	plasticity	plasticity	NOUN
aji-174	229	29	.	.	PUNCT
aji-174	230	1	4.1	4.1	NUM
aji-174	230	2	tobacco	tobacco	NOUN
aji-174	230	3	smoke	smoke	NOUN
aji-174	230	4	cigarette	cigarette	NOUN
aji-174	230	5	smoke	smoke	NOUN
aji-174	230	6	is	be	AUX
aji-174	230	7	one	one	NUM
aji-174	230	8	of	of	ADP
aji-174	230	9	the	the	DET
aji-174	230	10	most	most	ADV
aji-174	230	11	wellestablished	wellestablished	ADJ
aji-174	230	12	environmental	environmental	ADJ
aji-174	230	13	risk	risk	NOUN
aji-174	230	14	factors	factor	NOUN
aji-174	230	15	for	for	ADP
aji-174	230	16	ra	ra	PROPN
aji-174	230	17	and	and	CCONJ
aji-174	230	18	other	other	ADJ
aji-174	230	19	imids	imid	NOUN
aji-174	230	20	.	.	PUNCT
aji-174	231	1	it	it	PRON
aji-174	231	2	is	be	AUX
aji-174	231	3	a	a	DET
aji-174	231	4	complex	complex	ADJ
aji-174	231	5	mixture	mixture	NOUN
aji-174	231	6	of	of	ADP
aji-174	231	7	over	over	ADP
aji-174	231	8	7,000	7,000	NUM
aji-174	231	9	chemicals	chemical	NOUN
aji-174	231	10	,	,	PUNCT
aji-174	231	11	many	many	ADJ
aji-174	231	12	of	of	ADP
aji-174	231	13	which	which	PRON
aji-174	231	14	have	have	VERB
aji-174	231	15	demonstrable	demonstrable	ADJ
aji-174	231	16	epigenetic	epigenetic	ADJ
aji-174	231	17	effects	effect	NOUN
aji-174	231	18	.	.	PUNCT
aji-174	232	1	mechanism	mechanism	NOUN
aji-174	232	2	:	:	PUNCT
aji-174	232	3	chemicals	chemical	NOUN
aji-174	232	4	like	like	ADP
aji-174	232	5	benzene	benzene	NOUN
aji-174	232	6	and	and	CCONJ
aji-174	232	7	hydroquinone	hydroquinone	NOUN
aji-174	232	8	can	can	AUX
aji-174	232	9	directly	directly	ADV
aji-174	232	10	inhibit	inhibit	VERB
aji-174	232	11	the	the	DET
aji-174	232	12	activity	activity	NOUN
aji-174	232	13	of	of	ADP
aji-174	232	14	dnmts	dnmt	VERB
aji-174	232	15	by	by	ADP
aji-174	232	16	forming	form	VERB
aji-174	232	17	covalent	covalent	NOUN
aji-174	232	18	adducts	adduct	NOUN
aji-174	232	19	or	or	CCONJ
aji-174	232	20	by	by	ADP
aji-174	232	21	generating	generate	VERB
aji-174	232	22	reactive	reactive	ADJ
aji-174	232	23	oxygen	oxygen	NOUN
aji-174	232	24	species	specie	NOUN
aji-174	232	25	(	(	PUNCT
aji-174	232	26	ros	ros	PROPN
aji-174	232	27	)	)	PUNCT
aji-174	232	28	that	that	PRON
aji-174	232	29	interfere	interfere	VERB
aji-174	232	30	with	with	ADP
aji-174	232	31	enzymatic	enzymatic	ADJ
aji-174	232	32	function	function	NOUN
aji-174	232	33	.	.	PUNCT
aji-174	233	1	this	this	PRON
aji-174	233	2	leads	lead	VERB
aji-174	233	3	to	to	ADP
aji-174	233	4	dna	dna	PROPN
aji-174	233	5	hypomethylation	hypomethylation	NOUN
aji-174	233	6	.	.	PUNCT
aji-174	234	1	evidence	evidence	NOUN
aji-174	234	2	:	:	PUNCT
aji-174	234	3	smokers	smoker	NOUN
aji-174	234	4	exhibit	exhibit	VERB
aji-174	234	5	global	global	ADJ
aji-174	234	6	dna	dna	PROPN
aji-174	234	7	hypomethylation	hypomethylation	NOUN
aji-174	234	8	in	in	ADP
aji-174	234	9	peripheral	peripheral	ADJ
aji-174	234	10	blood	blood	NOUN
aji-174	234	11	mononuclear	mononuclear	ADJ
aji-174	234	12	cells	cell	NOUN
aji-174	234	13	(	(	PUNCT
aji-174	234	14	pbmcs	pbmcs	NOUN
aji-174	234	15	)	)	PUNCT
aji-174	234	16	.	.	PUNCT
aji-174	235	1	more	more	ADV
aji-174	235	2	specifically	specifically	ADV
aji-174	235	3	,	,	PUNCT
aji-174	235	4	smoking	smoking	NOUN
aji-174	235	5	has	have	AUX
aji-174	235	6	been	be	AUX
aji-174	235	7	linked	link	VERB
aji-174	235	8	to	to	ADP
aji-174	235	9	hypomethylation	hypomethylation	NOUN
aji-174	235	10	of	of	ADP
aji-174	235	11	the	the	DET
aji-174	235	12	ahrr	ahrr	NOUN
aji-174	235	13	(	(	PUNCT
aji-174	235	14	aryl	aryl	NOUN
aji-174	235	15	hydrocarbon	hydrocarbon	NOUN
aji-174	235	16	receptor	receptor	NOUN
aji-174	235	17	repressor	repressor	NOUN
aji-174	235	18	)	)	PUNCT
aji-174	235	19	gene	gene	NOUN
aji-174	235	20	and	and	CCONJ
aji-174	235	21	site	site	NOUN
aji-174	235	22	-	-	PUNCT
aji-174	235	23	specific	specific	ADJ
aji-174	235	24	hypomethylation	hypomethylation	NOUN
aji-174	235	25	at	at	ADP
aji-174	235	26	the	the	DET
aji-174	235	27	cxcl12	cxcl12	ADJ
aji-174	235	28	(	(	PUNCT
aji-174	235	29	involved	involve	VERB
aji-174	235	30	in	in	ADP
aji-174	235	31	ra	ra	PROPN
aji-174	235	32	pathogenesis	pathogenesis	NOUN
aji-174	235	33	)	)	PUNCT
aji-174	235	34	and	and	CCONJ
aji-174	235	35	il6	il6	NOUN
aji-174	235	36	promoters	promoter	NOUN
aji-174	235	37	in	in	ADP
aji-174	235	38	immune	immune	ADJ
aji-174	235	39	cells	cell	NOUN
aji-174	235	40	,	,	PUNCT
aji-174	235	41	promoting	promote	VERB
aji-174	235	42	a	a	DET
aji-174	235	43	pro	pro	ADJ
aji-174	235	44	-	-	ADJ
aji-174	235	45	inflammatory	inflammatory	ADJ
aji-174	235	46	state	state	NOUN
aji-174	235	47	(	(	PUNCT
aji-174	235	48	lim	lim	PROPN
aji-174	235	49	&	&	CCONJ
aji-174	235	50	kim	kim	PROPN
aji-174	235	51	,	,	PUNCT
aji-174	235	52	2024	2024	NUM
aji-174	235	53	;	;	PUNCT
aji-174	235	54	svendsen	svendsen	PROPN
aji-174	235	55	et	et	PROPN
aji-174	235	56	al	al	PROPN
aji-174	235	57	.	.	PROPN
aji-174	235	58	,	,	PUNCT
aji-174	235	59	2025	2025	NUM
aji-174	235	60	)	)	PUNCT
aji-174	235	61	.	.	PUNCT
aji-174	236	1	this	this	DET
aji-174	236	2	effect	effect	NOUN
aji-174	236	3	can	can	AUX
aji-174	236	4	persist	persist	VERB
aji-174	236	5	for	for	ADP
aji-174	236	6	years	year	NOUN
aji-174	236	7	after	after	ADP
aji-174	236	8	smoking	smoking	NOUN
aji-174	236	9	cessation	cessation	NOUN
aji-174	236	10	,	,	PUNCT
aji-174	236	11	illustrating	illustrate	VERB
aji-174	236	12	the	the	DET
aji-174	236	13	long	long	ADV
aji-174	236	14	-	-	PUNCT
aji-174	236	15	lasting	last	VERB
aji-174	236	16	impact	impact	NOUN
aji-174	236	17	of	of	ADP
aji-174	236	18	epigenetic	epigenetic	ADJ
aji-174	236	19	modification	modification	NOUN
aji-174	236	20	.	.	PUNCT
aji-174	237	1	4.2	4.2	NUM
aji-174	237	2	microbial	microbial	ADJ
aji-174	237	3	infections	infection	NOUN
aji-174	237	4	(	(	PUNCT
aji-174	237	5	e.g.	e.g.	ADV
aji-174	237	6	,	,	PUNCT
aji-174	237	7	epsteinbarr	epsteinbarr	PROPN
aji-174	237	8	virus	virus	NOUN
aji-174	237	9	)	)	PUNCT
aji-174	237	10	infections	infection	NOUN
aji-174	237	11	,	,	PUNCT
aji-174	237	12	particularly	particularly	ADV
aji-174	237	13	with	with	ADP
aji-174	237	14	the	the	DET
aji-174	237	15	epstein	epstein	PROPN
aji-174	237	16	-	-	PUNCT
aji-174	237	17	barr	barr	PROPN
aji-174	237	18	virus	virus	PROPN
aji-174	237	19	(	(	PUNCT
aji-174	237	20	ebv	ebv	NOUN
aji-174	237	21	)	)	PUNCT
aji-174	237	22	,	,	PUNCT
aji-174	237	23	are	be	AUX
aji-174	237	24	strongly	strongly	ADV
aji-174	237	25	associated	associate	VERB
aji-174	237	26	with	with	ADP
aji-174	237	27	an	an	DET
aji-174	237	28	increased	increase	VERB
aji-174	237	29	risk	risk	NOUN
aji-174	237	30	of	of	ADP
aji-174	237	31	sle	sle	PROPN
aji-174	237	32	,	,	PUNCT
aji-174	237	33	ms	ms	NOUN
aji-174	237	34	,	,	PUNCT
aji-174	237	35	and	and	CCONJ
aji-174	237	36	other	other	ADJ
aji-174	237	37	autoimmune	autoimmune	ADJ
aji-174	237	38	conditions	condition	NOUN
aji-174	237	39	.	.	PUNCT
aji-174	238	1	mechanism	mechanism	NOUN
aji-174	238	2	:	:	PUNCT
aji-174	238	3	ebv	ebv	NOUN
aji-174	238	4	infection	infection	NOUN
aji-174	238	5	induces	induce	VERB
aji-174	238	6	widespread	widespread	ADJ
aji-174	238	7	epigenetic	epigenetic	ADJ
aji-174	238	8	changes	change	NOUN
aji-174	238	9	in	in	ADP
aji-174	238	10	host	host	NOUN
aji-174	238	11	b	b	NOUN
aji-174	238	12	cells	cell	NOUN
aji-174	238	13	to	to	PART
aji-174	238	14	facilitate	facilitate	VERB
aji-174	238	15	its	its	PRON
aji-174	238	16	own	own	ADJ
aji-174	238	17	latency	latency	NOUN
aji-174	238	18	and	and	CCONJ
aji-174	238	19	proliferation	proliferation	NOUN
aji-174	238	20	.	.	PUNCT
aji-174	239	1	the	the	DET
aji-174	239	2	viral	viral	ADJ
aji-174	239	3	protein	protein	NOUN
aji-174	239	4	ebna2	ebna2	NOUN
aji-174	239	5	acts	act	VERB
aji-174	239	6	as	as	ADP
aji-174	239	7	a	a	DET
aji-174	239	8	transcriptional	transcriptional	ADJ
aji-174	239	9	regulator	regulator	NOUN
aji-174	239	10	that	that	PRON
aji-174	239	11	binds	bind	VERB
aji-174	239	12	to	to	ADP
aji-174	239	13	numerous	numerous	ADJ
aji-174	239	14	autoimmune	autoimmune	ADJ
aji-174	239	15	risk	risk	NOUN
aji-174	239	16	loci	locus	NOUN
aji-174	239	17	ajibola	ajibola	PROPN
aji-174	239	18	and	and	CCONJ
aji-174	239	19	ayodele	ayodele	PROPN
aji-174	239	20	;	;	PUNCT
aji-174	239	21	asian	asian	PROPN
aji-174	239	22	j.	j.	PROPN
aji-174	239	23	immunol	immunol	PROPN
aji-174	239	24	.	.	PROPN
aji-174	239	25	,	,	PUNCT
aji-174	239	26	vol	vol	NOUN
aji-174	239	27	.	.	PROPN
aji-174	239	28	8	8	NUM
aji-174	239	29	,	,	PUNCT
aji-174	239	30	no	no	INTJ
aji-174	239	31	.	.	NOUN
aji-174	239	32	1	1	NUM
aji-174	239	33	,	,	PUNCT
aji-174	239	34	pp	pp	ADJ
aji-174	239	35	.	.	PUNCT
aji-174	240	1	230	230	NUM
aji-174	240	2	-	-	SYM
aji-174	240	3	241	241	NUM
aji-174	240	4	,	,	PUNCT
aji-174	240	5	2025	2025	NUM
aji-174	240	6	;	;	PUNCT
aji-174	240	7	article	article	NOUN
aji-174	240	8	no.aji.144830	no.aji.144830	NOUN
aji-174	240	9	236	236	NUM
aji-174	240	10	identified	identify	VERB
aji-174	240	11	by	by	ADP
aji-174	240	12	gwas	gwas	PROPN
aji-174	240	13	,	,	PUNCT
aji-174	240	14	altering	alter	VERB
aji-174	240	15	their	their	PRON
aji-174	240	16	expression	expression	NOUN
aji-174	240	17	and	and	CCONJ
aji-174	240	18	histone	histone	NOUN
aji-174	240	19	modification	modification	NOUN
aji-174	240	20	landscape	landscape	NOUN
aji-174	240	21	.	.	PUNCT
aji-174	241	1	furthermore	furthermore	ADV
aji-174	241	2	,	,	PUNCT
aji-174	241	3	ebv	ebv	NOUN
aji-174	241	4	-	-	PUNCT
aji-174	241	5	encoded	encode	VERB
aji-174	241	6	latent	latent	NOUN
aji-174	241	7	membrane	membrane	NOUN
aji-174	241	8	protein	protein	NOUN
aji-174	241	9	1	1	NUM
aji-174	241	10	(	(	PUNCT
aji-174	241	11	lmp1	lmp1	NOUN
aji-174	241	12	)	)	PUNCT
aji-174	241	13	can	can	AUX
aji-174	241	14	dysregulate	dysregulate	VERB
aji-174	241	15	dnmt	dnmt	ADJ
aji-174	241	16	expression	expression	NOUN
aji-174	241	17	,	,	PUNCT
aji-174	241	18	leading	lead	VERB
aji-174	241	19	to	to	ADP
aji-174	241	20	hypomethylation	hypomethylation	NOUN
aji-174	241	21	and	and	CCONJ
aji-174	241	22	activation	activation	NOUN
aji-174	241	23	of	of	ADP
aji-174	241	24	endogenous	endogenous	ADJ
aji-174	241	25	retroviruses	retrovirus	NOUN
aji-174	241	26	and	and	CCONJ
aji-174	241	27	autoimmune	autoimmune	ADV
aji-174	241	28	-	-	PUNCT
aji-174	241	29	related	relate	VERB
aji-174	241	30	genes	gene	NOUN
aji-174	241	31	(	(	PUNCT
aji-174	241	32	viel	viel	NOUN
aji-174	241	33	,	,	PUNCT
aji-174	241	34	2024	2024	NUM
aji-174	241	35	;	;	PUNCT
aji-174	241	36	zhao	zhao	PROPN
aji-174	241	37	et	et	PROPN
aji-174	241	38	al	al	PROPN
aji-174	241	39	.	.	PROPN
aji-174	241	40	,	,	PUNCT
aji-174	241	41	2024	2024	NUM
aji-174	241	42	)	)	PUNCT
aji-174	241	43	)	)	PUNCT
aji-174	241	44	evidence	evidence	NOUN
aji-174	241	45	:	:	PUNCT
aji-174	241	46	patients	patient	NOUN
aji-174	241	47	with	with	ADP
aji-174	241	48	sle	sle	PROPN
aji-174	241	49	have	have	AUX
aji-174	241	50	been	be	AUX
aji-174	241	51	shown	show	VERB
aji-174	241	52	to	to	PART
aji-174	241	53	have	have	VERB
aji-174	241	54	aberrant	aberrant	ADJ
aji-174	241	55	hypomethylation	hypomethylation	NOUN
aji-174	241	56	of	of	ADP
aji-174	241	57	ebv	ebv	NOUN
aji-174	241	58	genes	gene	NOUN
aji-174	241	59	,	,	PUNCT
aji-174	241	60	leading	lead	VERB
aji-174	241	61	to	to	ADP
aji-174	241	62	loss	loss	NOUN
aji-174	241	63	of	of	ADP
aji-174	241	64	viral	viral	ADJ
aji-174	241	65	control	control	NOUN
aji-174	241	66	and	and	CCONJ
aji-174	241	67	a	a	DET
aji-174	241	68	higher	high	ADJ
aji-174	241	69	viral	viral	ADJ
aji-174	241	70	load	load	NOUN
aji-174	241	71	.	.	PUNCT
aji-174	242	1	the	the	DET
aji-174	242	2	cross	cross	NOUN
aji-174	242	3	-	-	NOUN
aji-174	242	4	reactivity	reactivity	NOUN
aji-174	242	5	between	between	ADP
aji-174	242	6	ebv	ebv	NOUN
aji-174	242	7	antigens	antigen	NOUN
aji-174	242	8	(	(	PUNCT
aji-174	242	9	e.g.	e.g.	ADV
aji-174	242	10	,	,	PUNCT
aji-174	242	11	ebna1	ebna1	ADJ
aji-174	242	12	)	)	PUNCT
aji-174	242	13	and	and	CCONJ
aji-174	242	14	self	self	NOUN
aji-174	242	15	-	-	PUNCT
aji-174	242	16	antigens	antigen	NOUN
aji-174	242	17	(	(	PUNCT
aji-174	242	18	e.g.	e.g.	ADV
aji-174	242	19	,	,	PUNCT
aji-174	242	20	sm	sm	PROPN
aji-174	242	21	in	in	ADP
aji-174	242	22	sle	sle	PROPN
aji-174	242	23	)	)	PUNCT
aji-174	242	24	in	in	ADP
aji-174	242	25	an	an	DET
aji-174	242	26	epigenetically	epigenetically	ADV
aji-174	242	27	permissive	permissive	ADJ
aji-174	242	28	environment	environment	NOUN
aji-174	242	29	may	may	AUX
aji-174	242	30	break	break	VERB
aji-174	242	31	tolerance	tolerance	NOUN
aji-174	242	32	.	.	PUNCT
aji-174	243	1	4.3	4.3	NUM
aji-174	243	2	diet	diet	NOUN
aji-174	243	3	and	and	CCONJ
aji-174	243	4	the	the	DET
aji-174	243	5	gut	gut	NOUN
aji-174	243	6	microbiome	microbiome	ADJ
aji-174	243	7	dietary	dietary	ADJ
aji-174	243	8	components	component	NOUN
aji-174	243	9	and	and	CCONJ
aji-174	243	10	the	the	DET
aji-174	243	11	metabolites	metabolite	NOUN
aji-174	243	12	produced	produce	VERB
aji-174	243	13	by	by	ADP
aji-174	243	14	the	the	DET
aji-174	243	15	commensal	commensal	ADJ
aji-174	243	16	gut	gut	NOUN
aji-174	243	17	microbiota	microbiota	NOUN
aji-174	243	18	are	be	AUX
aji-174	243	19	potent	potent	ADJ
aji-174	243	20	epigenetic	epigenetic	ADJ
aji-174	243	21	modifiers	modifier	NOUN
aji-174	243	22	that	that	PRON
aji-174	243	23	directly	directly	ADV
aji-174	243	24	influence	influence	VERB
aji-174	243	25	immune	immune	ADJ
aji-174	243	26	cell	cell	NOUN
aji-174	243	27	function	function	NOUN
aji-174	243	28	and	and	CCONJ
aji-174	243	29	mucosal	mucosal	NOUN
aji-174	243	30	integrity	integrity	NOUN
aji-174	243	31	.	.	PUNCT
aji-174	244	1	mechanism	mechanism	NOUN
aji-174	244	2	:	:	PUNCT
aji-174	244	3	methyl	methyl	NOUN
aji-174	244	4	donors	donor	NOUN
aji-174	244	5	:	:	PUNCT
aji-174	244	6	nutrients	nutrient	NOUN
aji-174	244	7	involved	involve	VERB
aji-174	244	8	in	in	ADP
aji-174	244	9	one	one	NUM
aji-174	244	10	-	-	PUNCT
aji-174	244	11	carbon	carbon	NOUN
aji-174	244	12	metabolism	metabolism	NOUN
aji-174	244	13	,	,	PUNCT
aji-174	244	14	such	such	ADJ
aji-174	244	15	as	as	ADP
aji-174	244	16	folate	folate	NOUN
aji-174	244	17	,	,	PUNCT
aji-174	244	18	vitamin	vitamin	NOUN
aji-174	244	19	b12	b12	NOUN
aji-174	244	20	,	,	PUNCT
aji-174	244	21	and	and	CCONJ
aji-174	244	22	choline	choline	NOUN
aji-174	244	23	are	be	AUX
aji-174	244	24	essential	essential	ADJ
aji-174	244	25	for	for	ADP
aji-174	244	26	generating	generate	VERB
aji-174	244	27	sadenosylmethionine	sadenosylmethionine	PROPN
aji-174	244	28	(	(	PUNCT
aji-174	244	29	sam	sam	PROPN
aji-174	244	30	)	)	PUNCT
aji-174	244	31	,	,	PUNCT
aji-174	244	32	the	the	DET
aji-174	244	33	universal	universal	ADJ
aji-174	244	34	methyl	methyl	NOUN
aji-174	244	35	donor	donor	NOUN
aji-174	244	36	for	for	ADP
aji-174	244	37	dna	dna	PROPN
aji-174	244	38	and	and	CCONJ
aji-174	244	39	histone	histone	NOUN
aji-174	244	40	methylation	methylation	NOUN
aji-174	244	41	.	.	PUNCT
aji-174	245	1	deficiencies	deficiency	NOUN
aji-174	245	2	in	in	ADP
aji-174	245	3	these	these	DET
aji-174	245	4	nutrients	nutrient	NOUN
aji-174	245	5	can	can	AUX
aji-174	245	6	lead	lead	VERB
aji-174	245	7	to	to	ADP
aji-174	245	8	global	global	ADJ
aji-174	245	9	hypomethylation	hypomethylation	NOUN
aji-174	245	10	.	.	PUNCT
aji-174	246	1	short	short	ADJ
aji-174	246	2	-	-	PUNCT
aji-174	246	3	chain	chain	NOUN
aji-174	246	4	fatty	fatty	NOUN
aji-174	246	5	acids	acid	NOUN
aji-174	246	6	(	(	PUNCT
aji-174	246	7	scfas	scfas	NOUN
aji-174	246	8	):	):	PUNCT
aji-174	246	9	butyrate	butyrate	NOUN
aji-174	246	10	,	,	PUNCT
aji-174	246	11	propionate	propionate	NOUN
aji-174	246	12	,	,	PUNCT
aji-174	246	13	and	and	CCONJ
aji-174	246	14	acetate	acetate	NOUN
aji-174	246	15	are	be	AUX
aji-174	246	16	produced	produce	VERB
aji-174	246	17	by	by	ADP
aji-174	246	18	bacterial	bacterial	ADJ
aji-174	246	19	fermentation	fermentation	NOUN
aji-174	246	20	of	of	ADP
aji-174	246	21	dietary	dietary	ADJ
aji-174	246	22	fiber	fiber	NOUN
aji-174	246	23	.	.	PUNCT
aji-174	247	1	butyrate	butyrate	NOUN
aji-174	247	2	is	be	AUX
aji-174	247	3	a	a	DET
aji-174	247	4	potent	potent	ADJ
aji-174	247	5	inhibitor	inhibitor	NOUN
aji-174	247	6	of	of	ADP
aji-174	247	7	hdac	hdac	NOUN
aji-174	247	8	(	(	PUNCT
aji-174	247	9	particularly	particularly	ADV
aji-174	247	10	class	class	NOUN
aji-174	247	11	i	i	PROPN
aji-174	247	12	and	and	CCONJ
aji-174	247	13	iia	iia	NOUN
aji-174	247	14	)	)	PUNCT
aji-174	247	15	.	.	PUNCT
aji-174	248	1	hdac	hdac	PROPN
aji-174	248	2	inhibition	inhibition	NOUN
aji-174	248	3	in	in	ADP
aji-174	248	4	immune	immune	ADJ
aji-174	248	5	cells	cell	NOUN
aji-174	248	6	,	,	PUNCT
aji-174	248	7	particularly	particularly	ADV
aji-174	248	8	in	in	ADP
aji-174	248	9	the	the	DET
aji-174	248	10	gut	gut	NOUN
aji-174	248	11	,	,	PUNCT
aji-174	248	12	promotes	promote	VERB
aji-174	248	13	the	the	DET
aji-174	248	14	development	development	NOUN
aji-174	248	15	and	and	CCONJ
aji-174	248	16	function	function	NOUN
aji-174	248	17	of	of	ADP
aji-174	248	18	regulatory	regulatory	ADJ
aji-174	248	19	t	t	NOUN
aji-174	248	20	cells	cell	NOUN
aji-174	248	21	(	(	PUNCT
aji-174	248	22	tregs	treg	NOUN
aji-174	248	23	)	)	PUNCT
aji-174	248	24	via	via	ADP
aji-174	248	25	hyperacetylation	hyperacetylation	NOUN
aji-174	248	26	of	of	ADP
aji-174	248	27	the	the	DET
aji-174	248	28	foxp3	foxp3	NOUN
aji-174	248	29	promoter	promoter	NOUN
aji-174	248	30	and	and	CCONJ
aji-174	248	31	other	other	ADJ
aji-174	248	32	loci	locus	NOUN
aji-174	248	33	,	,	PUNCT
aji-174	248	34	thereby	thereby	ADV
aji-174	248	35	enforcing	enforce	VERB
aji-174	248	36	immune	immune	ADJ
aji-174	248	37	tolerance	tolerance	NOUN
aji-174	248	38	(	(	PUNCT
aji-174	248	39	xu	xu	INTJ
aji-174	248	40	et	et	PROPN
aji-174	248	41	al	al	PROPN
aji-174	248	42	.	.	PROPN
aji-174	248	43	,	,	PUNCT
aji-174	248	44	2025	2025	NUM
aji-174	248	45	)	)	PUNCT
aji-174	248	46	evidence	evidence	NOUN
aji-174	248	47	:	:	PUNCT
aji-174	248	48	a	a	DET
aji-174	248	49	"	"	PUNCT
aji-174	248	50	western	western	ADJ
aji-174	248	51	diet	diet	NOUN
aji-174	248	52	"	"	PUNCT
aji-174	248	53	low	low	ADJ
aji-174	248	54	in	in	ADP
aji-174	248	55	fiber	fiber	NOUN
aji-174	248	56	reduces	reduce	VERB
aji-174	248	57	scfa	scfa	ADJ
aji-174	248	58	production	production	NOUN
aji-174	248	59	,	,	PUNCT
aji-174	248	60	leading	lead	VERB
aji-174	248	61	to	to	ADP
aji-174	248	62	decreased	decrease	VERB
aji-174	248	63	hdac	hdac	NOUN
aji-174	248	64	inhibition	inhibition	NOUN
aji-174	248	65	,	,	PUNCT
aji-174	248	66	impaired	impaired	ADJ
aji-174	248	67	treg	treg	PROPN
aji-174	248	68	function	function	PROPN
aji-174	248	69	,	,	PUNCT
aji-174	248	70	and	and	CCONJ
aji-174	248	71	a	a	DET
aji-174	248	72	heightened	heighten	VERB
aji-174	248	73	inflammatory	inflammatory	ADJ
aji-174	248	74	state	state	NOUN
aji-174	248	75	.	.	PUNCT
aji-174	249	1	butyrate	butyrate	ADJ
aji-174	249	2	supplementation	supplementation	NOUN
aji-174	249	3	has	have	AUX
aji-174	249	4	been	be	AUX
aji-174	249	5	shown	show	VERB
aji-174	249	6	to	to	PART
aji-174	249	7	ameliorate	ameliorate	VERB
aji-174	249	8	disease	disease	NOUN
aji-174	249	9	in	in	ADP
aji-174	249	10	animal	animal	NOUN
aji-174	249	11	models	model	NOUN
aji-174	249	12	of	of	ADP
aji-174	249	13	colitis	colitis	NOUN
aji-174	249	14	and	and	CCONJ
aji-174	249	15	ms	ms	NOUN
aji-174	249	16	(	(	PUNCT
aji-174	249	17	fisse	fisse	PROPN
aji-174	249	18	et	et	PROPN
aji-174	249	19	al	al	PROPN
aji-174	249	20	.	.	PROPN
aji-174	249	21	,	,	PUNCT
aji-174	249	22	2024	2024	NUM
aji-174	249	23	)	)	PUNCT
aji-174	249	24	.	.	PUNCT
aji-174	250	1	4.4	4.4	NUM
aji-174	250	2	ultraviolet	ultraviolet	NOUN
aji-174	250	3	(	(	PUNCT
aji-174	250	4	uv	uv	NOUN
aji-174	250	5	)	)	PUNCT
aji-174	250	6	radiation	radiation	NOUN
aji-174	250	7	uv	uv	NOUN
aji-174	250	8	radiation	radiation	NOUN
aji-174	250	9	is	be	AUX
aji-174	250	10	a	a	DET
aji-174	250	11	known	know	VERB
aji-174	250	12	trigger	trigger	NOUN
aji-174	250	13	for	for	ADP
aji-174	250	14	sle	sle	PROPN
aji-174	250	15	flares	flare	NOUN
aji-174	250	16	and	and	CCONJ
aji-174	250	17	skin	skin	NOUN
aji-174	250	18	manifestations	manifestation	NOUN
aji-174	250	19	.	.	PUNCT
aji-174	251	1	mechanism	mechanism	NOUN
aji-174	251	2	:	:	PUNCT
aji-174	251	3	uvb	uvb	ADJ
aji-174	251	4	exposure	exposure	NOUN
aji-174	251	5	can	can	AUX
aji-174	251	6	induce	induce	VERB
aji-174	251	7	dna	dna	ADJ
aji-174	251	8	damage	damage	NOUN
aji-174	251	9	and	and	CCONJ
aji-174	251	10	oxidative	oxidative	ADJ
aji-174	251	11	stress	stress	NOUN
aji-174	251	12	in	in	ADP
aji-174	251	13	keratinocytes	keratinocyte	NOUN
aji-174	251	14	,	,	PUNCT
aji-174	251	15	leading	lead	VERB
aji-174	251	16	to	to	ADP
aji-174	251	17	the	the	DET
aji-174	251	18	generation	generation	NOUN
aji-174	251	19	of	of	ADP
aji-174	251	20	ros	ros	PROPN
aji-174	251	21	.	.	PUNCT
aji-174	252	1	ros	ros	PROPN
aji-174	252	2	can	can	AUX
aji-174	252	3	directly	directly	ADV
aji-174	252	4	inhibit	inhibit	VERB
aji-174	252	5	dnmt1	dnmt1	ADJ
aji-174	252	6	activity	activity	NOUN
aji-174	252	7	and	and	CCONJ
aji-174	252	8	alter	alter	VERB
aji-174	252	9	the	the	DET
aji-174	252	10	activity	activity	NOUN
aji-174	252	11	of	of	ADP
aji-174	252	12	enzymes	enzyme	NOUN
aji-174	252	13	responsible	responsible	ADJ
aji-174	252	14	for	for	ADP
aji-174	252	15	histone	histone	NOUN
aji-174	252	16	modifications	modification	NOUN
aji-174	252	17	.	.	PUNCT
aji-174	253	1	this	this	PRON
aji-174	253	2	can	can	AUX
aji-174	253	3	cause	cause	VERB
aji-174	253	4	demethylation	demethylation	NOUN
aji-174	253	5	and	and	CCONJ
aji-174	253	6	overexpression	overexpression	NOUN
aji-174	253	7	of	of	ADP
aji-174	253	8	genes	gene	NOUN
aji-174	253	9	involved	involve	VERB
aji-174	253	10	in	in	ADP
aji-174	253	11	apoptosis	apoptosis	NOUN
aji-174	253	12	and	and	CCONJ
aji-174	253	13	inflammation	inflammation	NOUN
aji-174	253	14	,	,	PUNCT
aji-174	253	15	such	such	ADJ
aji-174	253	16	as	as	ADP
aji-174	253	17	cd70	cd70	PROPN
aji-174	253	18	and	and	CCONJ
aji-174	253	19	cd154	cd154	PROPN
aji-174	253	20	(	(	PUNCT
aji-174	253	21	barnes	barne	NOUN
aji-174	253	22	et	et	PROPN
aji-174	253	23	al	al	PROPN
aji-174	253	24	.	.	PROPN
aji-174	253	25	,	,	PUNCT
aji-174	253	26	2024	2024	NUM
aji-174	253	27	)	)	PUNCT
aji-174	253	28	.	.	PUNCT
aji-174	254	1	evidence	evidence	NOUN
aji-174	254	2	:	:	PUNCT
aji-174	254	3	uv	uv	NOUN
aji-174	254	4	irradiation	irradiation	NOUN
aji-174	254	5	of	of	ADP
aji-174	254	6	skin	skin	NOUN
aji-174	254	7	cells	cell	NOUN
aji-174	254	8	in	in	ADP
aji-174	254	9	culture	culture	NOUN
aji-174	254	10	induces	induce	VERB
aji-174	254	11	demethylation	demethylation	NOUN
aji-174	254	12	and	and	CCONJ
aji-174	254	13	overexpression	overexpression	NOUN
aji-174	254	14	of	of	ADP
aji-174	254	15	autoantigens	autoantigen	NOUN
aji-174	254	16	like	like	ADP
aji-174	254	17	ro	ro	NOUN
aji-174	254	18	/	/	SYM
aji-174	254	19	ssa	ssa	NOUN
aji-174	254	20	,	,	PUNCT
aji-174	254	21	potentially	potentially	ADV
aji-174	254	22	making	make	VERB
aji-174	254	23	them	they	PRON
aji-174	254	24	more	more	ADV
aji-174	254	25	visible	visible	ADJ
aji-174	254	26	to	to	ADP
aji-174	254	27	the	the	DET
aji-174	254	28	immune	immune	ADJ
aji-174	254	29	system	system	NOUN
aji-174	254	30	and	and	CCONJ
aji-174	254	31	initiating	initiate	VERB
aji-174	254	32	an	an	DET
aji-174	254	33	autoimmune	autoimmune	ADJ
aji-174	254	34	response	response	NOUN
aji-174	254	35	.	.	PUNCT
aji-174	255	1	4.5	4.5	NUM
aji-174	255	2	air	air	NOUN
aji-174	255	3	pollutants	pollutant	NOUN
aji-174	255	4	and	and	CCONJ
aji-174	255	5	chemicals	chemical	NOUN
aji-174	255	6	particulate	particulate	NOUN
aji-174	255	7	matter	matter	NOUN
aji-174	255	8	(	(	PUNCT
aji-174	255	9	pm2.5	pm2.5	NUM
aji-174	255	10	)	)	PUNCT
aji-174	255	11	,	,	PUNCT
aji-174	255	12	organic	organic	ADJ
aji-174	255	13	solvents	solvent	NOUN
aji-174	255	14	,	,	PUNCT
aji-174	255	15	and	and	CCONJ
aji-174	255	16	other	other	ADJ
aji-174	255	17	environmental	environmental	ADJ
aji-174	255	18	chemicals	chemical	NOUN
aji-174	255	19	have	have	AUX
aji-174	255	20	been	be	AUX
aji-174	255	21	implicated	implicate	VERB
aji-174	255	22	in	in	ADP
aji-174	255	23	the	the	DET
aji-174	255	24	pathogenesis	pathogenesis	NOUN
aji-174	255	25	of	of	ADP
aji-174	255	26	imids	imid	NOUN
aji-174	255	27	.	.	PUNCT
aji-174	256	1	mechanism	mechanism	NOUN
aji-174	256	2	:	:	PUNCT
aji-174	256	3	similar	similar	ADJ
aji-174	256	4	to	to	ADP
aji-174	256	5	tobacco	tobacco	NOUN
aji-174	256	6	smoke	smoke	NOUN
aji-174	256	7	,	,	PUNCT
aji-174	256	8	many	many	ADJ
aji-174	256	9	pollutants	pollutant	NOUN
aji-174	256	10	generate	generate	VERB
aji-174	256	11	oxidative	oxidative	ADJ
aji-174	256	12	stress	stress	NOUN
aji-174	256	13	,	,	PUNCT
aji-174	256	14	leading	lead	VERB
aji-174	256	15	to	to	ADP
aji-174	256	16	impaired	impair	VERB
aji-174	256	17	dnmt	dnmt	NOUN
aji-174	256	18	function	function	NOUN
aji-174	256	19	and	and	CCONJ
aji-174	256	20	global	global	ADJ
aji-174	256	21	hypomethylation	hypomethylation	NOUN
aji-174	256	22	.	.	PUNCT
aji-174	257	1	some	some	DET
aji-174	257	2	chemicals	chemical	NOUN
aji-174	257	3	can	can	AUX
aji-174	257	4	also	also	ADV
aji-174	257	5	directly	directly	ADV
aji-174	257	6	bind	bind	VERB
aji-174	257	7	to	to	ADP
aji-174	257	8	and	and	CCONJ
aji-174	257	9	activate	activate	VERB
aji-174	257	10	aryl	aryl	NOUN
aji-174	257	11	hydrocarbon	hydrocarbon	NOUN
aji-174	257	12	receptor	receptor	NOUN
aji-174	257	13	(	(	PUNCT
aji-174	257	14	ahr	ahr	PROPN
aji-174	257	15	)	)	PUNCT
aji-174	257	16	,	,	PUNCT
aji-174	257	17	a	a	DET
aji-174	257	18	ligand	ligand	NOUN
aji-174	257	19	-	-	PUNCT
aji-174	257	20	activated	activate	VERB
aji-174	257	21	transcription	transcription	NOUN
aji-174	257	22	factor	factor	NOUN
aji-174	257	23	that	that	PRON
aji-174	257	24	recruits	recruit	VERB
aji-174	257	25	a	a	DET
aji-174	257	26	variety	variety	NOUN
aji-174	257	27	of	of	ADP
aji-174	257	28	epigenetic	epigenetic	ADJ
aji-174	257	29	modifiers	modifier	NOUN
aji-174	257	30	to	to	PART
aji-174	257	31	target	target	VERB
aji-174	257	32	genes	gene	NOUN
aji-174	257	33	,	,	PUNCT
aji-174	257	34	influencing	influence	VERB
aji-174	257	35	th17	th17	PROPN
aji-174	257	36	/	/	SYM
aji-174	257	37	treg	treg	PROPN
aji-174	257	38	balance	balance	PROPN
aji-174	257	39	(	(	PUNCT
aji-174	257	40	wais	wais	PROPN
aji-174	257	41	and	and	CCONJ
aji-174	257	42	agrawal	agrawal	PROPN
aji-174	257	43	,	,	PUNCT
aji-174	257	44	2024	2024	NUM
aji-174	257	45	;	;	PUNCT
aji-174	258	1	hahn	hahn	PROPN
aji-174	258	2	et	et	PROPN
aji-174	258	3	al	al	PROPN
aji-174	258	4	.	.	PROPN
aji-174	258	5	,	,	PUNCT
aji-174	258	6	2024	2024	NUM
aji-174	258	7	)	)	PUNCT
aji-174	258	8	.	.	PUNCT
aji-174	259	1	evidence	evidence	NOUN
aji-174	259	2	:	:	PUNCT
aji-174	259	3	epidemiological	epidemiological	ADJ
aji-174	259	4	studies	study	NOUN
aji-174	259	5	link	link	VERB
aji-174	259	6	exposure	exposure	NOUN
aji-174	259	7	to	to	PART
aji-174	259	8	silica	silica	VERB
aji-174	259	9	dust	dust	NOUN
aji-174	259	10	and	and	CCONJ
aji-174	259	11	organic	organic	ADJ
aji-174	259	12	solvents	solvent	NOUN
aji-174	259	13	to	to	ADP
aji-174	259	14	an	an	DET
aji-174	259	15	increased	increase	VERB
aji-174	259	16	risk	risk	NOUN
aji-174	259	17	of	of	ADP
aji-174	259	18	sle	sle	PROPN
aji-174	259	19	,	,	PUNCT
aji-174	259	20	ra	ra	PROPN
aji-174	259	21	,	,	PUNCT
aji-174	259	22	and	and	CCONJ
aji-174	259	23	systemic	systemic	ADJ
aji-174	259	24	sclerosis	sclerosis	NOUN
aji-174	259	25	.	.	PUNCT
aji-174	260	1	studies	study	NOUN
aji-174	260	2	show	show	VERB
aji-174	260	3	that	that	SCONJ
aji-174	260	4	pm2.5	pm2.5	ADJ
aji-174	260	5	exposure	exposure	NOUN
aji-174	260	6	is	be	AUX
aji-174	260	7	associated	associate	VERB
aji-174	260	8	with	with	ADP
aji-174	260	9	altered	alter	VERB
aji-174	260	10	dna	dna	PROPN
aji-174	260	11	methylation	methylation	NOUN
aji-174	260	12	in	in	ADP
aji-174	260	13	inflammatory	inflammatory	ADJ
aji-174	260	14	genes	gene	NOUN
aji-174	260	15	.	.	PUNCT
aji-174	261	1	5	5	X
aji-174	261	2	.	.	PUNCT
aji-174	261	3	translational	translational	ADJ
aji-174	261	4	implications	implication	NOUN
aji-174	261	5	and	and	CCONJ
aji-174	261	6	future	future	ADJ
aji-174	261	7	directions	direction	NOUN
aji-174	261	8	the	the	DET
aji-174	261	9	profound	profound	ADJ
aji-174	261	10	understanding	understanding	NOUN
aji-174	261	11	of	of	ADP
aji-174	261	12	epigenetic	epigenetic	ADJ
aji-174	261	13	dysregulation	dysregulation	NOUN
aji-174	261	14	in	in	ADP
aji-174	261	15	immune	immune	NOUN
aji-174	261	16	-	-	PUNCT
aji-174	261	17	mediated	mediate	VERB
aji-174	261	18	diseases	disease	NOUN
aji-174	261	19	is	be	AUX
aji-174	261	20	rapidly	rapidly	ADV
aji-174	261	21	moving	move	VERB
aji-174	261	22	from	from	ADP
aji-174	261	23	bench	bench	NOUN
aji-174	261	24	to	to	ADP
aji-174	261	25	bedside	bedside	NOUN
aji-174	261	26	,	,	PUNCT
aji-174	261	27	offering	offer	VERB
aji-174	261	28	unprecedented	unprecedented	ADJ
aji-174	261	29	opportunities	opportunity	NOUN
aji-174	261	30	for	for	ADP
aji-174	261	31	improving	improve	VERB
aji-174	261	32	patient	patient	ADJ
aji-174	261	33	care	care	NOUN
aji-174	261	34	.	.	PUNCT
aji-174	262	1	the	the	DET
aji-174	262	2	dynamic	dynamic	ADJ
aji-174	262	3	and	and	CCONJ
aji-174	262	4	reversible	reversible	ADJ
aji-174	262	5	nature	nature	NOUN
aji-174	262	6	of	of	ADP
aji-174	262	7	epigenetic	epigenetic	ADJ
aji-174	262	8	marks	mark	NOUN
aji-174	262	9	positions	position	VERB
aji-174	262	10	them	they	PRON
aji-174	262	11	as	as	ADP
aji-174	262	12	ideal	ideal	ADJ
aji-174	262	13	targets	target	NOUN
aji-174	262	14	for	for	ADP
aji-174	262	15	novel	novel	ADJ
aji-174	262	16	diagnostic	diagnostic	ADJ
aji-174	262	17	strategies	strategy	NOUN
aji-174	262	18	and	and	CCONJ
aji-174	262	19	therapeutic	therapeutic	ADJ
aji-174	262	20	interventions	intervention	NOUN
aji-174	262	21	,	,	PUNCT
aji-174	262	22	heralding	herald	VERB
aji-174	262	23	a	a	DET
aji-174	262	24	new	new	ADJ
aji-174	262	25	era	era	NOUN
aji-174	262	26	of	of	ADP
aji-174	262	27	precision	precision	NOUN
aji-174	262	28	medicine	medicine	NOUN
aji-174	262	29	in	in	ADP
aji-174	262	30	autoimmunity	autoimmunity	NOUN
aji-174	262	31	.	.	PUNCT
aji-174	263	1	5.1	5.1	NUM
aji-174	263	2	epigenetic	epigenetic	ADJ
aji-174	263	3	biomarkers	biomarker	NOUN
aji-174	263	4	the	the	DET
aji-174	263	5	quest	quest	NOUN
aji-174	263	6	for	for	ADP
aji-174	263	7	specific	specific	ADJ
aji-174	263	8	,	,	PUNCT
aji-174	263	9	sensitive	sensitive	ADJ
aji-174	263	10	,	,	PUNCT
aji-174	263	11	and	and	CCONJ
aji-174	263	12	noninvasive	noninvasive	ADJ
aji-174	263	13	biomarkers	biomarker	NOUN
aji-174	263	14	is	be	AUX
aji-174	263	15	central	central	ADJ
aji-174	263	16	to	to	ADP
aji-174	263	17	improving	improve	VERB
aji-174	263	18	outcomes	outcome	NOUN
aji-174	263	19	in	in	ADP
aji-174	263	20	imids	imid	NOUN
aji-174	263	21	.	.	PUNCT
aji-174	264	1	epigenetic	epigenetic	ADJ
aji-174	264	2	marks	mark	NOUN
aji-174	264	3	,	,	PUNCT
aji-174	264	4	stable	stable	ADJ
aji-174	264	5	in	in	ADP
aji-174	264	6	biofluids	biofluid	NOUN
aji-174	264	7	and	and	CCONJ
aji-174	264	8	reflective	reflective	ADJ
aji-174	264	9	of	of	ADP
aji-174	264	10	dynamic	dynamic	ADJ
aji-174	264	11	disease	disease	NOUN
aji-174	264	12	activity	activity	NOUN
aji-174	264	13	,	,	PUNCT
aji-174	264	14	hold	hold	VERB
aji-174	264	15	immense	immense	ADJ
aji-174	264	16	promise	promise	NOUN
aji-174	264	17	.	.	PUNCT
aji-174	265	1	ajibola	ajibola	PROPN
aji-174	265	2	and	and	CCONJ
aji-174	265	3	ayodele	ayodele	PROPN
aji-174	265	4	;	;	PUNCT
aji-174	265	5	asian	asian	PROPN
aji-174	265	6	j.	j.	PROPN
aji-174	265	7	immunol	immunol	PROPN
aji-174	265	8	.	.	PROPN
aji-174	265	9	,	,	PUNCT
aji-174	265	10	vol	vol	NOUN
aji-174	265	11	.	.	PROPN
aji-174	265	12	8	8	NUM
aji-174	265	13	,	,	PUNCT
aji-174	265	14	no	no	INTJ
aji-174	265	15	.	.	NOUN
aji-174	265	16	1	1	NUM
aji-174	265	17	,	,	PUNCT
aji-174	265	18	pp	pp	ADJ
aji-174	265	19	.	.	PUNCT
aji-174	266	1	230	230	NUM
aji-174	266	2	-	-	SYM
aji-174	266	3	241	241	NUM
aji-174	266	4	,	,	PUNCT
aji-174	266	5	2025	2025	NUM
aji-174	266	6	;	;	PUNCT
aji-174	266	7	article	article	NOUN
aji-174	266	8	no.aji.144830	no.aji.144830	NOUN
aji-174	266	9	237	237	NUM
aji-174	266	10	table	table	NOUN
aji-174	266	11	2	2	NUM
aji-174	266	12	.	.	PUNCT
aji-174	266	13	epigenetic	epigenetic	ADJ
aji-174	266	14	and	and	CCONJ
aji-174	266	15	mirna	mirna	PROPN
aji-174	266	16	biomarkers	biomarker	NOUN
aji-174	266	17	for	for	ADP
aji-174	266	18	diagnosis	diagnosis	NOUN
aji-174	266	19	,	,	PUNCT
aji-174	266	20	monitoring	monitoring	NOUN
aji-174	266	21	,	,	PUNCT
aji-174	266	22	prognosis	prognosis	NOUN
aji-174	266	23	,	,	PUNCT
aji-174	266	24	and	and	CCONJ
aji-174	266	25	treatment	treatment	NOUN
aji-174	266	26	response	response	NOUN
aji-174	266	27	in	in	ADP
aji-174	266	28	sle	sle	PROPN
aji-174	266	29	and	and	CCONJ
aji-174	266	30	ra	ra	PROPN
aji-174	266	31	application	application	NOUN
aji-174	266	32	example	example	NOUN
aji-174	266	33	potential	potential	ADJ
aji-174	266	34	utility	utility	NOUN
aji-174	266	35	diagnosis	diagnosis	NOUN
aji-174	266	36	specific	specific	ADJ
aji-174	266	37	mirna	mirna	PROPN
aji-174	266	38	panel	panel	NOUN
aji-174	266	39	(	(	PUNCT
aji-174	266	40	e.g.	e.g.	ADV
aji-174	266	41	,	,	PUNCT
aji-174	266	42	mir-146a	mir-146a	ADJ
aji-174	266	43	,	,	PUNCT
aji-174	266	44	mir-155	mir-155	NOUN
aji-174	266	45	)	)	PUNCT
aji-174	266	46	in	in	ADP
aji-174	266	47	serum	serum	NOUN
aji-174	266	48	for	for	ADP
aji-174	266	49	sle	sle	PROPN
aji-174	266	50	earlier	early	ADV
aji-174	266	51	and	and	CCONJ
aji-174	266	52	more	more	ADV
aji-174	266	53	accurate	accurate	ADJ
aji-174	266	54	diagnosis	diagnosis	NOUN
aji-174	266	55	,	,	PUNCT
aji-174	266	56	especially	especially	ADV
aji-174	266	57	in	in	ADP
aji-174	266	58	seronegative	seronegative	ADJ
aji-174	266	59	patients	patient	NOUN
aji-174	266	60	disease	disease	NOUN
aji-174	266	61	monitoring	monitor	VERB
aji-174	266	62	global	global	ADJ
aji-174	266	63	dna	dna	PROPN
aji-174	266	64	methylation	methylation	NOUN
aji-174	266	65	levels	level	NOUN
aji-174	266	66	in	in	ADP
aji-174	266	67	pbmcs	pbmcs	NOUN
aji-174	266	68	in	in	ADP
aji-174	266	69	sle	sle	PROPN
aji-174	266	70	;	;	PUNCT
aji-174	266	71	cxcl12	cxcl12	ADJ
aji-174	266	72	methylation	methylation	NOUN
aji-174	266	73	in	in	ADP
aji-174	266	74	ra	ra	PROPN
aji-174	266	75	objective	objective	ADJ
aji-174	266	76	measure	measure	NOUN
aji-174	266	77	of	of	ADP
aji-174	266	78	disease	disease	NOUN
aji-174	266	79	activity	activity	NOUN
aji-174	266	80	;	;	PUNCT
aji-174	266	81	predict	predict	VERB
aji-174	266	82	flare	flare	NOUN
aji-174	266	83	-	-	PUNCT
aji-174	266	84	ups	up	NOUN
aji-174	266	85	prognosis	prognosis	NOUN
aji-174	266	86	methylation	methylation	NOUN
aji-174	266	87	status	status	NOUN
aji-174	266	88	of	of	ADP
aji-174	266	89	apoptosis	apoptosis	NOUN
aji-174	266	90	-	-	PUNCT
aji-174	266	91	related	relate	VERB
aji-174	266	92	genes	gene	NOUN
aji-174	266	93	in	in	ADP
aji-174	266	94	ra	ra	PROPN
aji-174	266	95	-	-	PUNCT
aji-174	266	96	fls	fls	PROPN
aji-174	266	97	predict	predict	VERB
aji-174	266	98	severity	severity	NOUN
aji-174	266	99	of	of	ADP
aji-174	266	100	joint	joint	ADJ
aji-174	266	101	destruction	destruction	NOUN
aji-174	266	102	and	and	CCONJ
aji-174	266	103	disease	disease	NOUN
aji-174	267	1	course	course	NOUN
aji-174	267	2	treatment	treatment	NOUN
aji-174	267	3	response	response	NOUN
aji-174	267	4	pre	pre	ADJ
aji-174	267	5	-	-	ADJ
aji-174	267	6	treatment	treatment	ADJ
aji-174	267	7	mir-125b	mir-125b	NOUN
aji-174	267	8	levels	level	NOUN
aji-174	267	9	predict	predict	VERB
aji-174	267	10	response	response	NOUN
aji-174	267	11	to	to	PART
aji-174	267	12	rituximab	rituximab	VERB
aji-174	267	13	in	in	ADP
aji-174	267	14	ra	ra	PROPN
aji-174	267	15	or	or	CCONJ
aji-174	267	16	sle	sle	PROPN
aji-174	267	17	diagnosis	diagnosis	NOUN
aji-174	267	18	and	and	CCONJ
aji-174	267	19	differential	differential	ADJ
aji-174	267	20	diagnosis	diagnosis	NOUN
aji-174	267	21	:	:	PUNCT
aji-174	267	22	dna	dna	PROPN
aji-174	267	23	methylation	methylation	NOUN
aji-174	267	24	signatures	signature	NOUN
aji-174	267	25	and	and	CCONJ
aji-174	267	26	circulating	circulate	VERB
aji-174	267	27	mirna	mirna	NOUN
aji-174	267	28	profiles	profile	NOUN
aji-174	267	29	can	can	AUX
aji-174	267	30	distinguish	distinguish	VERB
aji-174	267	31	patients	patient	NOUN
aji-174	267	32	with	with	ADP
aji-174	267	33	a	a	DET
aji-174	267	34	specific	specific	ADJ
aji-174	267	35	imid	imid	NOUN
aji-174	267	36	from	from	ADP
aji-174	267	37	healthy	healthy	ADJ
aji-174	267	38	controls	control	NOUN
aji-174	267	39	and	and	CCONJ
aji-174	267	40	,	,	PUNCT
aji-174	267	41	crucially	crucially	ADV
aji-174	267	42	,	,	PUNCT
aji-174	267	43	from	from	ADP
aji-174	267	44	those	those	PRON
aji-174	267	45	with	with	ADP
aji-174	267	46	other	other	ADJ
aji-174	267	47	clinically	clinically	ADV
aji-174	267	48	similar	similar	ADJ
aji-174	267	49	conditions	condition	NOUN
aji-174	267	50	.	.	PUNCT
aji-174	268	1	for	for	ADP
aji-174	268	2	instance	instance	NOUN
aji-174	268	3	,	,	PUNCT
aji-174	268	4	a	a	DET
aji-174	268	5	specific	specific	ADJ
aji-174	268	6	methylation	methylation	NOUN
aji-174	268	7	signature	signature	NOUN
aji-174	268	8	in	in	ADP
aji-174	268	9	synovial	synovial	ADJ
aji-174	268	10	tissue	tissue	NOUN
aji-174	268	11	or	or	CCONJ
aji-174	268	12	peripheral	peripheral	ADJ
aji-174	268	13	blood	blood	NOUN
aji-174	268	14	can	can	AUX
aji-174	268	15	differentiate	differentiate	VERB
aji-174	268	16	rheumatoid	rheumatoid	VERB
aji-174	268	17	arthritis	arthritis	NOUN
aji-174	268	18	from	from	ADP
aji-174	268	19	other	other	ADJ
aji-174	268	20	forms	form	NOUN
aji-174	268	21	of	of	ADP
aji-174	268	22	inflammatory	inflammatory	ADJ
aji-174	268	23	arthritis	arthritis	NOUN
aji-174	268	24	(	(	PUNCT
aji-174	268	25	e.g.	e.g.	ADV
aji-174	268	26	,	,	PUNCT
aji-174	268	27	psoriatic	psoriatic	ADJ
aji-174	268	28	arthritis	arthritis	NOUN
aji-174	268	29	)	)	PUNCT
aji-174	268	30	with	with	ADP
aji-174	268	31	higher	high	ADJ
aji-174	268	32	accuracy	accuracy	NOUN
aji-174	268	33	than	than	ADP
aji-174	268	34	current	current	ADJ
aji-174	268	35	serological	serological	ADJ
aji-174	268	36	tests	test	NOUN
aji-174	268	37	(	(	PUNCT
aji-174	268	38	proaño	proaño	X
aji-174	268	39	et	et	PROPN
aji-174	268	40	al	al	PROPN
aji-174	268	41	.	.	PROPN
aji-174	268	42	,	,	PUNCT
aji-174	268	43	2025	2025	NUM
aji-174	268	44	)	)	PUNCT
aji-174	268	45	monitoring	monitoring	NOUN
aji-174	268	46	disease	disease	NOUN
aji-174	268	47	activity	activity	NOUN
aji-174	268	48	and	and	CCONJ
aji-174	268	49	predicting	predict	VERB
aji-174	268	50	flares	flare	NOUN
aji-174	268	51	:	:	PUNCT
aji-174	268	52	unlike	unlike	ADP
aji-174	268	53	static	static	ADJ
aji-174	268	54	genetic	genetic	ADJ
aji-174	268	55	risk	risk	NOUN
aji-174	268	56	alleles	allele	NOUN
aji-174	268	57	,	,	PUNCT
aji-174	268	58	epigenetic	epigenetic	ADJ
aji-174	268	59	marks	mark	NOUN
aji-174	268	60	change	change	VERB
aji-174	268	61	with	with	ADP
aji-174	268	62	disease	disease	NOUN
aji-174	268	63	state	state	NOUN
aji-174	268	64	.	.	PUNCT
aji-174	269	1	serial	serial	ADJ
aji-174	269	2	analysis	analysis	NOUN
aji-174	269	3	of	of	ADP
aji-174	269	4	circulating	circulate	VERB
aji-174	269	5	cell	cell	NOUN
aji-174	269	6	-	-	PUNCT
aji-174	269	7	free	free	ADJ
aji-174	269	8	dna	dna	NOUN
aji-174	269	9	(	(	PUNCT
aji-174	269	10	cfdna	cfdna	NOUN
aji-174	269	11	)	)	PUNCT
aji-174	269	12	methylation	methylation	NOUN
aji-174	269	13	patterns	pattern	NOUN
aji-174	269	14	or	or	CCONJ
aji-174	269	15	mirna	mirna	NOUN
aji-174	269	16	levels	level	NOUN
aji-174	269	17	in	in	ADP
aji-174	269	18	serum	serum	NOUN
aji-174	269	19	can	can	AUX
aji-174	269	20	provide	provide	VERB
aji-174	269	21	a	a	DET
aji-174	269	22	real	real	ADJ
aji-174	269	23	-	-	PUNCT
aji-174	269	24	time	time	NOUN
aji-174	269	25	"	"	PUNCT
aji-174	269	26	epigenetic	epigenetic	ADJ
aji-174	269	27	snapshot	snapshot	NOUN
aji-174	269	28	"	"	PUNCT
aji-174	269	29	of	of	ADP
aji-174	269	30	disease	disease	NOUN
aji-174	269	31	activity	activity	NOUN
aji-174	269	32	,	,	PUNCT
aji-174	269	33	potentially	potentially	ADV
aji-174	269	34	predicting	predict	VERB
aji-174	269	35	impending	impending	ADJ
aji-174	269	36	flares	flare	NOUN
aji-174	269	37	before	before	SCONJ
aji-174	269	38	clinical	clinical	ADJ
aji-174	269	39	symptoms	symptom	NOUN
aji-174	269	40	manifest	manifest	VERB
aji-174	269	41	.	.	PUNCT
aji-174	270	1	this	this	PRON
aji-174	270	2	allows	allow	VERB
aji-174	270	3	for	for	ADP
aji-174	270	4	pre	pre	ADJ
aji-174	270	5	-	-	ADJ
aji-174	270	6	emptive	emptive	ADJ
aji-174	270	7	treatment	treatment	NOUN
aji-174	270	8	adjustments	adjustment	NOUN
aji-174	270	9	(	(	PUNCT
aji-174	270	10	liu	liu	PROPN
aji-174	270	11	et	et	PROPN
aji-174	270	12	al	al	PROPN
aji-174	270	13	.	.	PROPN
aji-174	270	14	,	,	PUNCT
aji-174	270	15	2024	2024	NUM
aji-174	270	16	)	)	PUNCT
aji-174	270	17	.	.	PUNCT
aji-174	271	1	prognosis	prognosis	NOUN
aji-174	271	2	and	and	CCONJ
aji-174	271	3	treatment	treatment	NOUN
aji-174	271	4	response	response	NOUN
aji-174	271	5	:	:	PUNCT
aji-174	271	6	epigenetic	epigenetic	ADJ
aji-174	271	7	profiles	profile	NOUN
aji-174	271	8	may	may	AUX
aji-174	271	9	predict	predict	VERB
aji-174	271	10	disease	disease	NOUN
aji-174	271	11	aggressiveness	aggressiveness	NOUN
aji-174	271	12	and	and	CCONJ
aji-174	271	13	likelihood	likelihood	NOUN
aji-174	271	14	of	of	ADP
aji-174	271	15	developing	develop	VERB
aji-174	271	16	extra	extra	ADJ
aji-174	271	17	-	-	ADJ
aji-174	271	18	articular	articular	ADJ
aji-174	271	19	manifestations	manifestation	NOUN
aji-174	271	20	.	.	PUNCT
aji-174	272	1	furthermore	furthermore	ADV
aji-174	272	2	,	,	PUNCT
aji-174	272	3	baseline	baseline	ADJ
aji-174	272	4	epigenetic	epigenetic	ADJ
aji-174	272	5	markers	marker	NOUN
aji-174	272	6	could	could	AUX
aji-174	272	7	forecast	forecast	VERB
aji-174	272	8	response	response	NOUN
aji-174	272	9	to	to	ADP
aji-174	272	10	specific	specific	ADJ
aji-174	272	11	therapies	therapy	NOUN
aji-174	272	12	(	(	PUNCT
aji-174	272	13	e.g.	e.g.	ADV
aji-174	272	14	,	,	PUNCT
aji-174	272	15	predicting	predict	VERB
aji-174	272	16	non	non	NOUN
aji-174	272	17	-	-	NOUN
aji-174	272	18	response	response	NOUN
aji-174	272	19	to	to	ADP
aji-174	272	20	tnf	tnf	PROPN
aji-174	272	21	inhibitors	inhibitor	NOUN
aji-174	272	22	)	)	PUNCT
aji-174	272	23	,	,	PUNCT
aji-174	272	24	enabling	enable	VERB
aji-174	272	25	a	a	DET
aji-174	272	26	more	more	ADV
aji-174	272	27	personalized	personalized	ADJ
aji-174	272	28	and	and	CCONJ
aji-174	272	29	efficient	efficient	ADJ
aji-174	272	30	treatment	treatment	NOUN
aji-174	272	31	approach	approach	NOUN
aji-174	272	32	from	from	ADP
aji-174	272	33	the	the	DET
aji-174	272	34	outset	outset	NOUN
aji-174	272	35	(	(	PUNCT
aji-174	272	36	shaikh	shaikh	PROPN
aji-174	272	37	et	et	PROPN
aji-174	272	38	al	al	PROPN
aji-174	272	39	.	.	PROPN
aji-174	272	40	,	,	PUNCT
aji-174	272	41	2024	2024	NUM
aji-174	272	42	)	)	PUNCT
aji-174	272	43	.	.	PUNCT
aji-174	273	1	5.2	5.2	NUM
aji-174	273	2	epigenetic	epigenetic	ADJ
aji-174	273	3	therapy	therapy	NOUN
aji-174	273	4	the	the	DET
aji-174	273	5	concept	concept	NOUN
aji-174	273	6	of	of	ADP
aji-174	273	7	pharmacologically	pharmacologically	ADV
aji-174	273	8	reversing	reverse	VERB
aji-174	273	9	aberrant	aberrant	ADJ
aji-174	273	10	epigenetic	epigenetic	ADJ
aji-174	273	11	marks	mark	NOUN
aji-174	273	12	to	to	PART
aji-174	273	13	restore	restore	VERB
aji-174	273	14	normal	normal	ADJ
aji-174	273	15	gene	gene	NOUN
aji-174	273	16	expression	expression	NOUN
aji-174	273	17	is	be	AUX
aji-174	273	18	a	a	DET
aji-174	273	19	groundbreaking	groundbreake	VERB
aji-174	273	20	therapeutic	therapeutic	ADJ
aji-174	273	21	strategy	strategy	NOUN
aji-174	273	22	.	.	PUNCT
aji-174	274	1	while	while	SCONJ
aji-174	274	2	most	most	ADJ
aji-174	274	3	epigenetic	epigenetic	ADJ
aji-174	274	4	drugs	drug	NOUN
aji-174	274	5	are	be	AUX
aji-174	274	6	currently	currently	ADV
aji-174	274	7	used	use	VERB
aji-174	274	8	in	in	ADP
aji-174	274	9	oncology	oncology	NOUN
aji-174	274	10	,	,	PUNCT
aji-174	274	11	their	their	PRON
aji-174	274	12	repurposing	repurpose	VERB
aji-174	274	13	for	for	ADP
aji-174	274	14	autoimmunity	autoimmunity	NOUN
aji-174	274	15	is	be	AUX
aji-174	274	16	actively	actively	ADV
aji-174	274	17	being	be	AUX
aji-174	274	18	explored	explore	VERB
aji-174	274	19	.	.	PUNCT
aji-174	275	1	dnmt	dnmt	NOUN
aji-174	275	2	inhibitors	inhibitor	NOUN
aji-174	275	3	(	(	PUNCT
aji-174	275	4	dnmti	dnmti	NOUN
aji-174	275	5	):	):	PUNCT
aji-174	275	6	drugs	drug	NOUN
aji-174	275	7	like	like	ADP
aji-174	275	8	azacitidine	azacitidine	NOUN
aji-174	275	9	and	and	CCONJ
aji-174	275	10	decitabine	decitabine	NOUN
aji-174	275	11	are	be	AUX
aji-174	275	12	approved	approve	VERB
aji-174	275	13	for	for	ADP
aji-174	275	14	myelodysplastic	myelodysplastic	ADJ
aji-174	275	15	syndromes	syndrome	NOUN
aji-174	275	16	.	.	PUNCT
aji-174	276	1	their	their	PRON
aji-174	276	2	use	use	NOUN
aji-174	276	3	in	in	ADP
aji-174	276	4	autoimmunity	autoimmunity	NOUN
aji-174	276	5	is	be	AUX
aji-174	276	6	paradoxical	paradoxical	ADJ
aji-174	276	7	;	;	PUNCT
aji-174	276	8	while	while	SCONJ
aji-174	276	9	they	they	PRON
aji-174	276	10	can	can	AUX
aji-174	276	11	reverse	reverse	VERB
aji-174	276	12	pathological	pathological	ADJ
aji-174	276	13	hypermethylation	hypermethylation	NOUN
aji-174	276	14	of	of	ADP
aji-174	276	15	silenced	silence	VERB
aji-174	276	16	genes	gene	NOUN
aji-174	276	17	,	,	PUNCT
aji-174	276	18	their	their	PRON
aji-174	276	19	primary	primary	ADJ
aji-174	276	20	effect	effect	NOUN
aji-174	276	21	is	be	AUX
aji-174	276	22	global	global	ADJ
aji-174	276	23	hypomethylation	hypomethylation	NOUN
aji-174	276	24	,	,	PUNCT
aji-174	276	25	which	which	PRON
aji-174	276	26	could	could	AUX
aji-174	276	27	theoretically	theoretically	ADV
aji-174	276	28	exacerbate	exacerbate	VERB
aji-174	276	29	diseases	disease	NOUN
aji-174	276	30	like	like	ADP
aji-174	276	31	sle	sle	PROPN
aji-174	276	32	.	.	PUNCT
aji-174	277	1	the	the	DET
aji-174	277	2	future	future	NOUN
aji-174	277	3	lies	lie	VERB
aji-174	277	4	in	in	ADP
aji-174	277	5	developing	develop	VERB
aji-174	277	6	targeted	target	VERB
aji-174	277	7	delivery	delivery	NOUN
aji-174	277	8	systems	system	NOUN
aji-174	277	9	(	(	PUNCT
aji-174	277	10	e.g.	e.g.	ADV
aji-174	277	11	,	,	PUNCT
aji-174	277	12	antibody	antibody	NOUN
aji-174	277	13	-	-	PUNCT
aji-174	277	14	drug	drug	NOUN
aji-174	277	15	conjugates	conjugate	NOUN
aji-174	277	16	)	)	PUNCT
aji-174	277	17	to	to	ADP
aji-174	277	18	specific	specific	ADJ
aji-174	277	19	cell	cell	NOUN
aji-174	277	20	types	type	NOUN
aji-174	277	21	or	or	CCONJ
aji-174	277	22	employing	employ	VERB
aji-174	277	23	low	low	ADJ
aji-174	277	24	-	-	PUNCT
aji-174	277	25	dose	dose	NOUN
aji-174	277	26	regimens	regimen	NOUN
aji-174	277	27	to	to	PART
aji-174	277	28	achieve	achieve	VERB
aji-174	277	29	gene	gene	NOUN
aji-174	277	30	-	-	PUNCT
aji-174	277	31	specific	specific	NOUN
aji-174	277	32	rather	rather	ADV
aji-174	277	33	than	than	ADP
aji-174	277	34	global	global	ADJ
aji-174	277	35	effects	effect	NOUN
aji-174	277	36	(	(	PUNCT
aji-174	277	37	wen	wen	NOUN
aji-174	277	38	et	et	PROPN
aji-174	277	39	al	al	PROPN
aji-174	277	40	.	.	PROPN
aji-174	277	41	,	,	PUNCT
aji-174	277	42	2025	2025	NUM
aji-174	277	43	)	)	PUNCT
aji-174	277	44	.	.	PUNCT
aji-174	278	1	hdac	hdac	PROPN
aji-174	278	2	inhibitors	inhibitor	NOUN
aji-174	278	3	(	(	PUNCT
aji-174	278	4	hdaci	hdaci	NOUN
aji-174	278	5	):	):	PUNCT
aji-174	278	6	this	this	DET
aji-174	278	7	class	class	NOUN
aji-174	278	8	has	have	AUX
aji-174	278	9	shown	show	VERB
aji-174	278	10	greater	great	ADJ
aji-174	278	11	immediate	immediate	ADJ
aji-174	278	12	promise	promise	NOUN
aji-174	278	13	.	.	PUNCT
aji-174	279	1	pan	pan	ADJ
aji-174	279	2	-	-	ADJ
aji-174	279	3	hdac	hdac	NOUN
aji-174	279	4	inhibitors	inhibitor	NOUN
aji-174	279	5	like	like	ADP
aji-174	279	6	vorinostat	vorinostat	NOUN
aji-174	279	7	and	and	CCONJ
aji-174	279	8	givinostat	givinostat	NOUN
aji-174	279	9	have	have	AUX
aji-174	279	10	demonstrated	demonstrate	VERB
aji-174	279	11	efficacy	efficacy	NOUN
aji-174	279	12	in	in	ADP
aji-174	279	13	preclinical	preclinical	ADJ
aji-174	279	14	models	model	NOUN
aji-174	279	15	of	of	ADP
aji-174	279	16	ra	ra	PROPN
aji-174	279	17	,	,	PUNCT
aji-174	279	18	sle	sle	PROPN
aji-174	279	19	,	,	PUNCT
aji-174	279	20	and	and	CCONJ
aji-174	279	21	ms	ms	NOUN
aji-174	279	22	by	by	ADP
aji-174	279	23	suppressing	suppress	VERB
aji-174	279	24	proinflammatory	proinflammatory	ADJ
aji-174	279	25	cytokine	cytokine	NOUN
aji-174	279	26	production	production	NOUN
aji-174	279	27	and	and	CCONJ
aji-174	279	28	promoting	promote	VERB
aji-174	279	29	treg	treg	PROPN
aji-174	279	30	function	function	NOUN
aji-174	279	31	.	.	PUNCT
aji-174	280	1	more	more	ADV
aji-174	280	2	selective	selective	ADJ
aji-174	280	3	hdac	hdac	NOUN
aji-174	280	4	inhibitors	inhibitor	NOUN
aji-174	280	5	(	(	PUNCT
aji-174	280	6	e.g.	e.g.	ADV
aji-174	280	7	,	,	PUNCT
aji-174	280	8	targeting	target	VERB
aji-174	280	9	hdac6	hdac6	PROPN
aji-174	280	10	,	,	PUNCT
aji-174	280	11	hdac11	hdac11	NOUN
aji-174	280	12	)	)	PUNCT
aji-174	280	13	are	be	AUX
aji-174	280	14	in	in	ADP
aji-174	280	15	development	development	NOUN
aji-174	280	16	to	to	PART
aji-174	280	17	enhance	enhance	VERB
aji-174	280	18	efficacy	efficacy	NOUN
aji-174	280	19	and	and	CCONJ
aji-174	280	20	reduce	reduce	VERB
aji-174	280	21	offtarget	offtarget	NOUN
aji-174	280	22	effects	effect	NOUN
aji-174	280	23	(	(	PUNCT
aji-174	280	24	.	.	PUNCT
aji-174	281	1	notably	notably	ADV
aji-174	281	2	,	,	PUNCT
aji-174	281	3	the	the	DET
aji-174	281	4	scfa	scfa	ADJ
aji-174	281	5	butyrate	butyrate	NOUN
aji-174	281	6	is	be	AUX
aji-174	281	7	a	a	DET
aji-174	281	8	natural	natural	ADJ
aji-174	281	9	hdaci	hdaci	NOUN
aji-174	281	10	,	,	PUNCT
aji-174	281	11	providing	provide	VERB
aji-174	281	12	a	a	DET
aji-174	281	13	strong	strong	ADJ
aji-174	281	14	rationale	rationale	NOUN
aji-174	281	15	for	for	ADP
aji-174	281	16	dietary	dietary	ADJ
aji-174	281	17	and	and	CCONJ
aji-174	281	18	microbiome	microbiome	NOUN
aji-174	281	19	-	-	PUNCT
aji-174	281	20	based	base	VERB
aji-174	281	21	interventions	intervention	NOUN
aji-174	281	22	(	(	PUNCT
aji-174	281	23	yue	yue	PROPN
aji-174	281	24	et	et	PROPN
aji-174	281	25	al	al	PROPN
aji-174	281	26	.	.	PROPN
aji-174	281	27	,	,	PUNCT
aji-174	281	28	2025	2025	NUM
aji-174	281	29	)	)	PUNCT
aji-174	281	30	.	.	PUNCT
aji-174	282	1	bromodomain	bromodomain	NOUN
aji-174	282	2	and	and	CCONJ
aji-174	282	3	extra	extra	ADJ
aji-174	282	4	-	-	ADJ
aji-174	282	5	terminal	terminal	ADJ
aji-174	282	6	(	(	PUNCT
aji-174	282	7	bet	bet	NOUN
aji-174	282	8	)	)	PUNCT
aji-174	282	9	inhibitors	inhibitor	NOUN
aji-174	282	10	:	:	PUNCT
aji-174	282	11	these	these	DET
aji-174	282	12	compounds	compound	NOUN
aji-174	282	13	disrupt	disrupt	VERB
aji-174	282	14	the	the	DET
aji-174	282	15	reading	reading	NOUN
aji-174	282	16	of	of	ADP
aji-174	282	17	histone	histone	NOUN
aji-174	282	18	acetylation	acetylation	NOUN
aji-174	282	19	marks	mark	NOUN
aji-174	282	20	by	by	ADP
aji-174	282	21	bet	bet	ADJ
aji-174	282	22	proteins	protein	NOUN
aji-174	282	23	.	.	PUNCT
aji-174	283	1	they	they	PRON
aji-174	283	2	have	have	AUX
aji-174	283	3	potent	potent	VERB
aji-174	283	4	anti	anti	ADJ
aji-174	283	5	-	-	ADJ
aji-174	283	6	inflammatory	inflammatory	ADJ
aji-174	283	7	effects	effect	NOUN
aji-174	283	8	by	by	ADP
aji-174	283	9	downregulating	downregulate	VERB
aji-174	283	10	key	key	ADJ
aji-174	283	11	inflammatory	inflammatory	ADJ
aji-174	283	12	genes	gene	NOUN
aji-174	283	13	(	(	PUNCT
aji-174	283	14	e.g.	e.g.	ADV
aji-174	283	15	,	,	PUNCT
aji-174	283	16	nfkb	nfkb	PROPN
aji-174	283	17	,	,	PUNCT
aji-174	283	18	il6	il6	NOUN
aji-174	283	19	)	)	PUNCT
aji-174	283	20	and	and	CCONJ
aji-174	283	21	have	have	AUX
aji-174	283	22	shown	show	VERB
aji-174	283	23	efficacy	efficacy	NOUN
aji-174	283	24	in	in	ADP
aji-174	283	25	multiple	multiple	ADJ
aji-174	283	26	animal	animal	NOUN
aji-174	283	27	models	model	NOUN
aji-174	283	28	of	of	ADP
aji-174	283	29	imids	imid	NOUN
aji-174	283	30	(	(	PUNCT
aji-174	283	31	khokhar	khokhar	PROPN
aji-174	283	32	et	et	PROPN
aji-174	283	33	al	al	PROPN
aji-174	283	34	.	.	PROPN
aji-174	283	35	,	,	PUNCT
aji-174	283	36	2024	2024	NUM
aji-174	283	37	)	)	PUNCT
aji-174	283	38	.	.	PUNCT
aji-174	284	1	mirna	mirna	NOUN
aji-174	284	2	-	-	PUNCT
aji-174	284	3	based	base	VERB
aji-174	284	4	therapeutics	therapeutic	NOUN
aji-174	284	5	:	:	PUNCT
aji-174	284	6	this	this	DET
aji-174	284	7	approach	approach	NOUN
aji-174	284	8	offers	offer	VERB
aji-174	284	9	exquisite	exquisite	ADJ
aji-174	284	10	specificity	specificity	NOUN
aji-174	284	11	.	.	PUNCT
aji-174	285	1	mimics	mimic	VERB
aji-174	285	2	(	(	PUNCT
aji-174	285	3	to	to	PART
aji-174	285	4	restore	restore	VERB
aji-174	285	5	levels	level	NOUN
aji-174	285	6	of	of	ADP
aji-174	285	7	deficient	deficient	ADJ
aji-174	285	8	mirnas	mirna	NOUN
aji-174	285	9	like	like	ADP
aji-174	285	10	mir-146a	mir-146a	NOUN
aji-174	285	11	)	)	PUNCT
aji-174	285	12	and	and	CCONJ
aji-174	285	13	antagomirs	antagomir	NOUN
aji-174	285	14	or	or	CCONJ
aji-174	285	15	locked	lock	VERB
aji-174	285	16	nucleic	nucleic	ADJ
aji-174	285	17	acids	acid	NOUN
aji-174	285	18	(	(	PUNCT
aji-174	285	19	lnas	lna	NOUN
aji-174	285	20	)	)	PUNCT
aji-174	285	21	(	(	PUNCT
aji-174	285	22	to	to	PART
aji-174	285	23	silence	silence	VERB
aji-174	285	24	overexpressed	overexpressed	ADJ
aji-174	285	25	mirnas	mirna	NOUN
aji-174	285	26	like	like	ADP
aji-174	285	27	mir-155	mir-155	NOUN
aji-174	285	28	)	)	PUNCT
aji-174	285	29	are	be	AUX
aji-174	285	30	in	in	ADP
aji-174	285	31	various	various	ADJ
aji-174	285	32	stages	stage	NOUN
aji-174	285	33	of	of	ADP
aji-174	285	34	preclinical	preclinical	ADJ
aji-174	285	35	and	and	CCONJ
aji-174	285	36	early	early	ADJ
aji-174	285	37	clinical	clinical	ADJ
aji-174	285	38	development	development	NOUN
aji-174	285	39	.	.	PUNCT
aji-174	286	1	the	the	DET
aji-174	286	2	major	major	ADJ
aji-174	286	3	challenge	challenge	NOUN
aji-174	286	4	remains	remain	VERB
aji-174	286	5	the	the	DET
aji-174	286	6	efficient	efficient	ADJ
aji-174	286	7	and	and	CCONJ
aji-174	286	8	targeted	target	VERB
aji-174	286	9	delivery	delivery	NOUN
aji-174	286	10	of	of	ADP
aji-174	286	11	these	these	DET
aji-174	286	12	oligonucleotides	oligonucleotide	NOUN
aji-174	286	13	to	to	ADP
aji-174	286	14	relevant	relevant	ADJ
aji-174	286	15	immune	immune	ADJ
aji-174	286	16	cells	cell	NOUN
aji-174	286	17	in	in	ADP
aji-174	286	18	vivo	vivo	NOUN
aji-174	286	19	(	(	PUNCT
aji-174	286	20	bannazadeh	bannazadeh	PROPN
aji-174	286	21	baghi	baghi	VERB
aji-174	286	22	et	et	PROPN
aji-174	286	23	al	al	PROPN
aji-174	286	24	.	.	PROPN
aji-174	286	25	,	,	PUNCT
aji-174	286	26	2024	2024	NUM
aji-174	286	27	)	)	PUNCT
aji-174	286	28	.	.	PUNCT
aji-174	287	1	ajibola	ajibola	PROPN
aji-174	287	2	and	and	CCONJ
aji-174	287	3	ayodele	ayodele	PROPN
aji-174	287	4	;	;	PUNCT
aji-174	287	5	asian	asian	PROPN
aji-174	287	6	j.	j.	PROPN
aji-174	287	7	immunol	immunol	PROPN
aji-174	287	8	.	.	PROPN
aji-174	287	9	,	,	PUNCT
aji-174	287	10	vol	vol	NOUN
aji-174	287	11	.	.	PROPN
aji-174	287	12	8	8	NUM
aji-174	287	13	,	,	PUNCT
aji-174	287	14	no	no	INTJ
aji-174	287	15	.	.	NOUN
aji-174	287	16	1	1	NUM
aji-174	287	17	,	,	PUNCT
aji-174	287	18	pp	pp	ADJ
aji-174	287	19	.	.	PUNCT
aji-174	288	1	230	230	NUM
aji-174	288	2	-	-	SYM
aji-174	288	3	241	241	NUM
aji-174	288	4	,	,	PUNCT
aji-174	288	5	2025	2025	NUM
aji-174	288	6	;	;	PUNCT
aji-174	288	7	article	article	NOUN
aji-174	288	8	no.aji.144830	no.aji.144830	NOUN
aji-174	288	9	238	238	NUM
aji-174	288	10	6	6	NUM
aji-174	288	11	.	.	PUNCT
aji-174	289	1	conclusion	conclusion	VERB
aji-174	289	2	the	the	DET
aji-174	289	3	investigation	investigation	NOUN
aji-174	289	4	into	into	ADP
aji-174	289	5	epigenetic	epigenetic	ADJ
aji-174	289	6	dysregulation	dysregulation	NOUN
aji-174	289	7	has	have	AUX
aji-174	289	8	fundamentally	fundamentally	ADV
aji-174	289	9	reshaped	reshape	VERB
aji-174	289	10	our	our	PRON
aji-174	289	11	understanding	understanding	NOUN
aji-174	289	12	of	of	ADP
aji-174	289	13	immune	immune	NOUN
aji-174	289	14	-	-	PUNCT
aji-174	289	15	mediated	mediate	VERB
aji-174	289	16	diseases	disease	NOUN
aji-174	289	17	.	.	PUNCT
aji-174	290	1	no	no	ADV
aji-174	290	2	longer	long	ADV
aji-174	290	3	viewed	view	VERB
aji-174	290	4	as	as	ADP
aji-174	290	5	disorders	disorder	NOUN
aji-174	290	6	governed	govern	VERB
aji-174	290	7	solely	solely	ADV
aji-174	290	8	by	by	ADP
aji-174	290	9	a	a	DET
aji-174	290	10	deterministic	deterministic	ADJ
aji-174	290	11	genetic	genetic	ADJ
aji-174	290	12	code	code	NOUN
aji-174	290	13	,	,	PUNCT
aji-174	290	14	imids	imid	NOUN
aji-174	290	15	are	be	AUX
aji-174	290	16	now	now	ADV
aji-174	290	17	recognized	recognize	VERB
aji-174	290	18	as	as	ADP
aji-174	290	19	conditions	condition	NOUN
aji-174	290	20	where	where	SCONJ
aji-174	290	21	dynamic	dynamic	ADJ
aji-174	290	22	epigenetic	epigenetic	ADJ
aji-174	290	23	mechanisms	mechanism	NOUN
aji-174	290	24	interpret	interpret	VERB
aji-174	290	25	genetic	genetic	ADJ
aji-174	290	26	susceptibility	susceptibility	NOUN
aji-174	290	27	through	through	ADP
aji-174	290	28	the	the	DET
aji-174	290	29	lens	lens	NOUN
aji-174	290	30	of	of	ADP
aji-174	290	31	environmental	environmental	ADJ
aji-174	290	32	exposure	exposure	NOUN
aji-174	290	33	.	.	PUNCT
aji-174	291	1	this	this	DET
aji-174	291	2	review	review	NOUN
aji-174	291	3	has	have	AUX
aji-174	291	4	synthesized	synthesize	VERB
aji-174	291	5	compelling	compelling	ADJ
aji-174	291	6	evidence	evidence	NOUN
aji-174	291	7	that	that	PRON
aji-174	291	8	establishes	establish	VERB
aji-174	291	9	aberrant	aberrant	ADJ
aji-174	291	10	dna	dna	PROPN
aji-174	291	11	methylation	methylation	NOUN
aji-174	291	12	,	,	PUNCT
aji-174	291	13	histone	histone	NOUN
aji-174	291	14	modifications	modification	NOUN
aji-174	291	15	,	,	PUNCT
aji-174	291	16	and	and	CCONJ
aji-174	291	17	non	non	ADJ
aji-174	291	18	-	-	ADJ
aji-174	291	19	coding	code	VERB
aji-174	291	20	rna	rna	NOUN
aji-174	291	21	expression	expression	NOUN
aji-174	291	22	not	not	PART
aji-174	291	23	as	as	ADP
aji-174	291	24	mere	mere	ADJ
aji-174	291	25	epiphenomena	epiphenomena	PROPN
aji-174	291	26	,	,	PUNCT
aji-174	291	27	but	but	CCONJ
aji-174	291	28	as	as	ADP
aji-174	291	29	central	central	ADJ
aji-174	291	30	drivers	driver	NOUN
aji-174	291	31	of	of	ADP
aji-174	291	32	pathogenesis	pathogenesis	NOUN
aji-174	291	33	.	.	PUNCT
aji-174	292	1	these	these	DET
aji-174	292	2	mechanisms	mechanism	NOUN
aji-174	292	3	directly	directly	ADV
aji-174	292	4	mediate	mediate	VERB
aji-174	292	5	the	the	DET
aji-174	292	6	loss	loss	NOUN
aji-174	292	7	of	of	ADP
aji-174	292	8	immune	immune	ADJ
aji-174	292	9	tolerance	tolerance	NOUN
aji-174	292	10	,	,	PUNCT
aji-174	292	11	hyperactivation	hyperactivation	NOUN
aji-174	292	12	of	of	ADP
aji-174	292	13	inflammatory	inflammatory	ADJ
aji-174	292	14	pathways	pathway	NOUN
aji-174	292	15	,	,	PUNCT
aji-174	292	16	and	and	CCONJ
aji-174	292	17	tissue	tissue	NOUN
aji-174	292	18	damage	damage	NOUN
aji-174	292	19	characteristic	characteristic	NOUN
aji-174	292	20	of	of	ADP
aji-174	292	21	diseases	disease	NOUN
aji-174	292	22	like	like	ADP
aji-174	292	23	sle	sle	PROPN
aji-174	292	24	,	,	PUNCT
aji-174	292	25	ra	ra	PROPN
aji-174	292	26	,	,	PUNCT
aji-174	292	27	ms	ms	NOUN
aji-174	292	28	,	,	PUNCT
aji-174	292	29	and	and	CCONJ
aji-174	292	30	ibd	ibd	PROPN
aji-174	292	31	.	.	PUNCT
aji-174	293	1	the	the	DET
aji-174	293	2	environmental	environmental	ADJ
aji-174	293	3	dimension	dimension	NOUN
aji-174	293	4	is	be	AUX
aji-174	293	5	particularly	particularly	ADV
aji-174	293	6	pivotal	pivotal	ADJ
aji-174	293	7	,	,	PUNCT
aji-174	293	8	with	with	ADP
aji-174	293	9	factors	factor	NOUN
aji-174	293	10	such	such	ADJ
aji-174	293	11	as	as	ADP
aji-174	293	12	tobacco	tobacco	NOUN
aji-174	293	13	smoke	smoke	NOUN
aji-174	293	14	,	,	PUNCT
aji-174	293	15	viral	viral	ADJ
aji-174	293	16	infections	infection	NOUN
aji-174	293	17	(	(	PUNCT
aji-174	293	18	notably	notably	ADV
aji-174	293	19	ebv	ebv	NOUN
aji-174	293	20	)	)	PUNCT
aji-174	293	21	,	,	PUNCT
aji-174	293	22	diet	diet	NOUN
aji-174	293	23	,	,	PUNCT
aji-174	293	24	and	and	CCONJ
aji-174	293	25	the	the	DET
aji-174	293	26	gut	gut	NOUN
aji-174	293	27	microbiome	microbiome	NOUN
aji-174	293	28	acting	act	VERB
aji-174	293	29	as	as	ADP
aji-174	293	30	powerful	powerful	ADJ
aji-174	293	31	epigenetic	epigenetic	ADJ
aji-174	293	32	modifiers	modifier	NOUN
aji-174	293	33	.	.	PUNCT
aji-174	294	1	these	these	DET
aji-174	294	2	triggers	trigger	NOUN
aji-174	294	3	can	can	AUX
aji-174	294	4	induce	induce	VERB
aji-174	294	5	stable	stable	ADJ
aji-174	294	6	,	,	PUNCT
aji-174	294	7	heritable	heritable	ADJ
aji-174	294	8	changes	change	NOUN
aji-174	294	9	in	in	ADP
aji-174	294	10	gene	gene	NOUN
aji-174	294	11	expression	expression	NOUN
aji-174	294	12	that	that	PRON
aji-174	294	13	lower	lower	VERB
aji-174	294	14	the	the	DET
aji-174	294	15	threshold	threshold	NOUN
aji-174	294	16	for	for	ADP
aji-174	294	17	autoimmunity	autoimmunity	NOUN
aji-174	294	18	,	,	PUNCT
aji-174	294	19	effectively	effectively	ADV
aji-174	294	20	encoding	encode	VERB
aji-174	294	21	the	the	DET
aji-174	294	22	memory	memory	NOUN
aji-174	294	23	of	of	ADP
aji-174	294	24	environmental	environmental	ADJ
aji-174	294	25	insults	insult	NOUN
aji-174	294	26	within	within	ADP
aji-174	294	27	the	the	DET
aji-174	294	28	immune	immune	ADJ
aji-174	294	29	system	system	NOUN
aji-174	294	30	and	and	CCONJ
aji-174	294	31	explaining	explain	VERB
aji-174	294	32	the	the	DET
aji-174	294	33	notable	notable	ADJ
aji-174	294	34	discordance	discordance	NOUN
aji-174	294	35	in	in	ADP
aji-174	294	36	genetically	genetically	ADV
aji-174	294	37	identical	identical	ADJ
aji-174	294	38	twins	twin	NOUN
aji-174	294	39	.	.	PUNCT
aji-174	295	1	this	this	PRON
aji-174	295	2	profound	profound	ADJ
aji-174	295	3	mechanistic	mechanistic	ADJ
aji-174	295	4	insight	insight	NOUN
aji-174	295	5	unlocks	unlock	VERB
aji-174	295	6	immense	immense	ADJ
aji-174	295	7	translational	translational	ADJ
aji-174	295	8	potential	potential	NOUN
aji-174	295	9	.	.	PUNCT
aji-174	296	1	the	the	DET
aji-174	296	2	dynamic	dynamic	ADJ
aji-174	296	3	nature	nature	NOUN
aji-174	296	4	of	of	ADP
aji-174	296	5	the	the	DET
aji-174	296	6	epigenome	epigenome	NOUN
aji-174	296	7	offers	offer	VERB
aji-174	296	8	a	a	DET
aji-174	296	9	unique	unique	ADJ
aji-174	296	10	opportunity	opportunity	NOUN
aji-174	296	11	to	to	PART
aji-174	296	12	develop	develop	VERB
aji-174	296	13	novel	novel	ADJ
aji-174	296	14	epigenetic	epigenetic	ADJ
aji-174	296	15	biomarkers	biomarker	NOUN
aji-174	296	16	for	for	ADP
aji-174	296	17	early	early	ADJ
aji-174	296	18	diagnosis	diagnosis	NOUN
aji-174	296	19	,	,	PUNCT
aji-174	296	20	precise	precise	ADJ
aji-174	296	21	prognosis	prognosis	NOUN
aji-174	296	22	,	,	PUNCT
aji-174	296	23	and	and	CCONJ
aji-174	296	24	real	real	ADJ
aji-174	296	25	-	-	PUNCT
aji-174	296	26	time	time	NOUN
aji-174	296	27	monitoring	monitoring	NOUN
aji-174	296	28	of	of	ADP
aji-174	296	29	disease	disease	NOUN
aji-174	296	30	activity	activity	NOUN
aji-174	296	31	,	,	PUNCT
aji-174	296	32	moving	move	VERB
aji-174	296	33	beyond	beyond	ADP
aji-174	296	34	the	the	DET
aji-174	296	35	limitations	limitation	NOUN
aji-174	296	36	of	of	ADP
aji-174	296	37	current	current	ADJ
aji-174	296	38	serological	serological	ADJ
aji-174	296	39	and	and	CCONJ
aji-174	296	40	clinical	clinical	ADJ
aji-174	296	41	markers	marker	NOUN
aji-174	296	42	.	.	PUNCT
aji-174	297	1	furthermore	furthermore	ADV
aji-174	297	2	,	,	PUNCT
aji-174	297	3	the	the	DET
aji-174	297	4	reversibility	reversibility	NOUN
aji-174	297	5	of	of	ADP
aji-174	297	6	epigenetic	epigenetic	ADJ
aji-174	297	7	marks	mark	NOUN
aji-174	297	8	paves	pave	VERB
aji-174	297	9	the	the	DET
aji-174	297	10	way	way	NOUN
aji-174	297	11	for	for	ADP
aji-174	297	12	a	a	DET
aji-174	297	13	revolutionary	revolutionary	ADJ
aji-174	297	14	therapeutic	therapeutic	ADJ
aji-174	297	15	strategy	strategy	NOUN
aji-174	297	16	:	:	PUNCT
aji-174	297	17	epigenetic	epigenetic	ADJ
aji-174	297	18	therapy	therapy	NOUN
aji-174	297	19	.	.	PUNCT
aji-174	298	1	the	the	DET
aji-174	298	2	repurposing	repurposing	NOUN
aji-174	298	3	and	and	CCONJ
aji-174	298	4	refinement	refinement	NOUN
aji-174	298	5	of	of	ADP
aji-174	298	6	drugs	drug	NOUN
aji-174	298	7	targeting	target	VERB
aji-174	298	8	dnmts	dnmt	VERB
aji-174	298	9	,	,	PUNCT
aji-174	298	10	hdacs	hdac	NOUN
aji-174	298	11	,	,	PUNCT
aji-174	298	12	bet	bet	NOUN
aji-174	298	13	proteins	protein	NOUN
aji-174	298	14	,	,	PUNCT
aji-174	298	15	and	and	CCONJ
aji-174	298	16	specific	specific	ADJ
aji-174	298	17	mirnas	mirna	NOUN
aji-174	298	18	hold	hold	VERB
aji-174	298	19	the	the	DET
aji-174	298	20	promise	promise	NOUN
aji-174	298	21	of	of	ADP
aji-174	298	22	not	not	PART
aji-174	298	23	just	just	ADV
aji-174	298	24	suppressing	suppress	VERB
aji-174	298	25	inflammation	inflammation	NOUN
aji-174	298	26	but	but	CCONJ
aji-174	298	27	potentially	potentially	ADV
aji-174	298	28	restoring	restore	VERB
aji-174	298	29	immunological	immunological	ADJ
aji-174	298	30	balance	balance	NOUN
aji-174	298	31	and	and	CCONJ
aji-174	298	32	inducing	induce	VERB
aji-174	298	33	long	long	ADJ
aji-174	298	34	-	-	PUNCT
aji-174	298	35	term	term	NOUN
aji-174	298	36	remission	remission	NOUN
aji-174	298	37	by	by	ADP
aji-174	298	38	reversing	reverse	VERB
aji-174	298	39	the	the	DET
aji-174	298	40	root	root	NOUN
aji-174	298	41	epigenetic	epigenetic	ADJ
aji-174	298	42	dysfunction	dysfunction	NOUN
aji-174	298	43	.	.	PUNCT
aji-174	299	1	however	however	ADV
aji-174	299	2	,	,	PUNCT
aji-174	299	3	the	the	DET
aji-174	299	4	path	path	NOUN
aji-174	299	5	forward	forward	ADV
aji-174	299	6	is	be	AUX
aji-174	299	7	not	not	PART
aji-174	299	8	without	without	ADP
aji-174	299	9	challenges	challenge	NOUN
aji-174	299	10	.	.	PUNCT
aji-174	300	1	the	the	DET
aji-174	300	2	field	field	NOUN
aji-174	300	3	must	must	AUX
aji-174	300	4	overcome	overcome	VERB
aji-174	300	5	hurdles	hurdle	NOUN
aji-174	300	6	related	relate	VERB
aji-174	300	7	to	to	ADP
aji-174	300	8	the	the	DET
aji-174	300	9	cell	cell	NOUN
aji-174	300	10	-	-	PUNCT
aji-174	300	11	type	type	NOUN
aji-174	300	12	specificity	specificity	NOUN
aji-174	300	13	of	of	ADP
aji-174	300	14	interventions	intervention	NOUN
aji-174	300	15	,	,	PUNCT
aji-174	300	16	the	the	DET
aji-174	300	17	complex	complex	ADJ
aji-174	300	18	crosstalk	crosstalk	NOUN
aji-174	300	19	within	within	ADP
aji-174	300	20	the	the	DET
aji-174	300	21	epigenome	epigenome	NOUN
aji-174	300	22	,	,	PUNCT
aji-174	300	23	and	and	CCONJ
aji-174	300	24	the	the	DET
aji-174	300	25	long	long	ADJ
aji-174	300	26	-	-	PUNCT
aji-174	300	27	term	term	NOUN
aji-174	300	28	safety	safety	NOUN
aji-174	300	29	of	of	ADP
aji-174	300	30	modulating	modulate	VERB
aji-174	300	31	these	these	DET
aji-174	300	32	fundamental	fundamental	ADJ
aji-174	300	33	regulatory	regulatory	ADJ
aji-174	300	34	systems	system	NOUN
aji-174	300	35	.	.	PUNCT
aji-174	301	1	future	future	ADJ
aji-174	301	2	research	research	NOUN
aji-174	301	3	must	must	AUX
aji-174	301	4	focus	focus	VERB
aji-174	301	5	on	on	ADP
aji-174	301	6	large	large	ADJ
aji-174	301	7	-	-	PUNCT
aji-174	301	8	scale	scale	NOUN
aji-174	301	9	integrative	integrative	ADJ
aji-174	301	10	multi	multi	ADJ
aji-174	301	11	-	-	ADJ
aji-174	301	12	omics	omics	ADJ
aji-174	301	13	studies	study	NOUN
aji-174	301	14	to	to	PART
aji-174	301	15	validate	validate	VERB
aji-174	301	16	biomarkers	biomarker	NOUN
aji-174	301	17	and	and	CCONJ
aji-174	301	18	on	on	ADP
aji-174	301	19	developing	develop	VERB
aji-174	301	20	novel	novel	ADJ
aji-174	301	21	targeted	target	VERB
aji-174	301	22	delivery	delivery	NOUN
aji-174	301	23	systems	system	NOUN
aji-174	301	24	to	to	PART
aji-174	301	25	enhance	enhance	VERB
aji-174	301	26	the	the	DET
aji-174	301	27	precision	precision	NOUN
aji-174	301	28	of	of	ADP
aji-174	301	29	epigenetic	epigenetic	ADJ
aji-174	301	30	drugs	drug	NOUN
aji-174	301	31	.	.	PUNCT
aji-174	302	1	in	in	ADP
aji-174	302	2	conclusion	conclusion	NOUN
aji-174	302	3	,	,	PUNCT
aji-174	302	4	the	the	DET
aji-174	302	5	study	study	NOUN
aji-174	302	6	of	of	ADP
aji-174	302	7	epigenetics	epigenetic	NOUN
aji-174	302	8	has	have	AUX
aji-174	302	9	provided	provide	VERB
aji-174	302	10	the	the	DET
aji-174	302	11	missing	miss	VERB
aji-174	302	12	link	link	NOUN
aji-174	302	13	between	between	ADP
aji-174	302	14	genes	gene	NOUN
aji-174	302	15	and	and	CCONJ
aji-174	302	16	environment	environment	NOUN
aji-174	302	17	in	in	ADP
aji-174	302	18	immune	immune	NOUN
aji-174	302	19	-	-	PUNCT
aji-174	302	20	mediated	mediate	VERB
aji-174	302	21	diseases	disease	NOUN
aji-174	302	22	.	.	PUNCT
aji-174	303	1	it	it	PRON
aji-174	303	2	offers	offer	VERB
aji-174	303	3	a	a	DET
aji-174	303	4	more	more	ADV
aji-174	303	5	complete	complete	ADJ
aji-174	303	6	and	and	CCONJ
aji-174	303	7	nuanced	nuanced	ADJ
aji-174	303	8	disease	disease	NOUN
aji-174	303	9	model	model	NOUN
aji-174	303	10	and	and	CCONJ
aji-174	303	11	,	,	PUNCT
aji-174	303	12	most	most	ADV
aji-174	303	13	importantly	importantly	ADV
aji-174	303	14	,	,	PUNCT
aji-174	303	15	illuminates	illuminate	VERB
aji-174	303	16	a	a	DET
aji-174	303	17	promising	promising	ADJ
aji-174	303	18	path	path	NOUN
aji-174	303	19	toward	toward	ADP
aji-174	303	20	personalized	personalized	ADJ
aji-174	303	21	medicine	medicine	NOUN
aji-174	303	22	.	.	PUNCT
aji-174	304	1	by	by	ADP
aji-174	304	2	reading	read	VERB
aji-174	304	3	and	and	CCONJ
aji-174	304	4	rewriting	rewrite	VERB
aji-174	304	5	the	the	DET
aji-174	304	6	epigenetic	epigenetic	ADJ
aji-174	304	7	code	code	NOUN
aji-174	304	8	that	that	PRON
aji-174	304	9	goes	go	VERB
aji-174	304	10	awry	awry	ADJ
aji-174	304	11	in	in	ADP
aji-174	304	12	autoimmunity	autoimmunity	NOUN
aji-174	304	13	,	,	PUNCT
aji-174	304	14	we	we	PRON
aji-174	304	15	are	be	AUX
aji-174	304	16	poised	poise	VERB
aji-174	304	17	to	to	PART
aji-174	304	18	develop	develop	VERB
aji-174	304	19	more	more	ADV
aji-174	304	20	effective	effective	ADJ
aji-174	304	21	strategies	strategy	NOUN
aji-174	304	22	for	for	ADP
aji-174	304	23	prediction	prediction	NOUN
aji-174	304	24	,	,	PUNCT
aji-174	304	25	prevention	prevention	NOUN
aji-174	304	26	,	,	PUNCT
aji-174	304	27	and	and	CCONJ
aji-174	304	28	treatment	treatment	NOUN
aji-174	304	29	,	,	PUNCT
aji-174	304	30	ultimately	ultimately	ADV
aji-174	304	31	aiming	aim	VERB
aji-174	304	32	to	to	PART
aji-174	304	33	restore	restore	VERB
aji-174	304	34	the	the	DET
aji-174	304	35	delicate	delicate	ADJ
aji-174	304	36	balance	balance	NOUN
aji-174	304	37	of	of	ADP
aji-174	304	38	the	the	DET
aji-174	304	39	immune	immune	ADJ
aji-174	304	40	system	system	NOUN
aji-174	304	41	and	and	CCONJ
aji-174	304	42	improve	improve	VERB
aji-174	304	43	the	the	DET
aji-174	304	44	lives	life	NOUN
aji-174	304	45	of	of	ADP
aji-174	304	46	millions	million	NOUN
aji-174	304	47	of	of	ADP
aji-174	304	48	patients	patient	NOUN
aji-174	304	49	worldwide	worldwide	ADV
aji-174	304	50	.	.	PUNCT
aji-174	305	1	consent	consent	NOUN
aji-174	305	2	it	it	PRON
aji-174	305	3	is	be	AUX
aji-174	305	4	not	not	PART
aji-174	305	5	applicable	applicable	ADJ
aji-174	305	6	.	.	PUNCT
aji-174	306	1	ethical	ethical	ADJ
aji-174	306	2	approval	approval	NOUN
aji-174	306	3	it	it	PRON
aji-174	306	4	is	be	AUX
aji-174	306	5	not	not	PART
aji-174	306	6	applicable	applicable	ADJ
aji-174	306	7	.	.	PUNCT
aji-174	307	1	disclaimer	disclaimer	NOUN
aji-174	307	2	(	(	PUNCT
aji-174	307	3	artificial	artificial	ADJ
aji-174	307	4	intelligence	intelligence	NOUN
aji-174	307	5	)	)	PUNCT
aji-174	307	6	author(s	author(s	NOUN
aji-174	307	7	)	)	PUNCT
aji-174	307	8	hereby	hereby	ADV
aji-174	307	9	declare	declare	VERB
aji-174	307	10	that	that	SCONJ
aji-174	307	11	no	no	DET
aji-174	307	12	generative	generative	NOUN
aji-174	307	13	ai	ai	VERB
aji-174	307	14	technologies	technology	NOUN
aji-174	307	15	such	such	ADJ
aji-174	307	16	as	as	ADP
aji-174	307	17	large	large	ADJ
aji-174	307	18	language	language	NOUN
aji-174	307	19	models	model	NOUN
aji-174	307	20	(	(	PUNCT
aji-174	307	21	chatgpt	chatgpt	NOUN
aji-174	307	22	,	,	PUNCT
aji-174	307	23	copilot	copilot	NOUN
aji-174	307	24	,	,	PUNCT
aji-174	307	25	etc	etc	X
aji-174	307	26	.	.	X
aji-174	307	27	)	)	PUNCT
aji-174	307	28	and	and	CCONJ
aji-174	307	29	text	text	NOUN
aji-174	307	30	-	-	PUNCT
aji-174	307	31	to	to	ADP
aji-174	307	32	-	-	PUNCT
aji-174	307	33	image	image	NOUN
aji-174	307	34	generators	generator	NOUN
aji-174	307	35	have	have	AUX
aji-174	307	36	been	be	AUX
aji-174	307	37	used	use	VERB
aji-174	307	38	during	during	ADP
aji-174	307	39	the	the	DET
aji-174	307	40	writing	writing	NOUN
aji-174	307	41	or	or	CCONJ
aji-174	307	42	editing	editing	NOUN
aji-174	307	43	of	of	ADP
aji-174	307	44	this	this	DET
aji-174	307	45	manuscript	manuscript	NOUN
aji-174	307	46	.	.	PUNCT
aji-174	308	1	competing	compete	VERB
aji-174	308	2	interests	interest	NOUN
aji-174	308	3	authors	author	NOUN
aji-174	308	4	have	have	AUX
aji-174	308	5	declared	declare	VERB
aji-174	308	6	that	that	SCONJ
aji-174	308	7	no	no	DET
aji-174	308	8	competing	compete	VERB
aji-174	308	9	interests	interest	NOUN
aji-174	308	10	exist	exist	VERB
aji-174	308	11	.	.	PUNCT
aji-174	309	1	references	reference	NOUN
aji-174	309	2	antonazzo	antonazzo	PROPN
aji-174	309	3	,	,	PUNCT
aji-174	309	4	g.	g.	PROPN
aji-174	309	5	,	,	PUNCT
aji-174	309	6	gaudet	gaudet	PROPN
aji-174	309	7	,	,	PUNCT
aji-174	309	8	p.	p.	NOUN
aji-174	309	9	,	,	PUNCT
aji-174	309	10	lovering	lovering	NOUN
aji-174	309	11	,	,	PUNCT
aji-174	309	12	r.	r.	PROPN
aji-174	309	13	c.	c.	PROPN
aji-174	309	14	,	,	PUNCT
aji-174	309	15	&	&	CCONJ
aji-174	309	16	attrill	attrill	PROPN
aji-174	309	17	,	,	PUNCT
aji-174	309	18	h.	h.	PROPN
aji-174	309	19	(	(	PUNCT
aji-174	309	20	2024	2024	NUM
aji-174	309	21	)	)	PUNCT
aji-174	309	22	.	.	PUNCT
aji-174	310	1	representation	representation	NOUN
aji-174	310	2	of	of	ADP
aji-174	310	3	noncoding	noncode	VERB
aji-174	310	4	rna	rna	NOUN
aji-174	310	5	-	-	PUNCT
aji-174	310	6	mediated	mediate	VERB
aji-174	310	7	regulation	regulation	NOUN
aji-174	310	8	of	of	ADP
aji-174	310	9	gene	gene	NOUN
aji-174	310	10	expression	expression	NOUN
aji-174	310	11	using	use	VERB
aji-174	310	12	the	the	DET
aji-174	310	13	gene	gene	NOUN
aji-174	310	14	ontology	ontology	NOUN
aji-174	310	15	.	.	PUNCT
aji-174	311	1	rna	rna	NOUN
aji-174	311	2	biology	biology	NOUN
aji-174	311	3	,	,	PUNCT
aji-174	311	4	21(1	21(1	NUM
aji-174	311	5	)	)	PUNCT
aji-174	311	6	,	,	PUNCT
aji-174	311	7	981–993	981–993	NUM
aji-174	311	8	.	.	PUNCT
aji-174	312	1	araki	araki	PROPN
aji-174	312	2	,	,	PUNCT
aji-174	312	3	y.	y.	PROPN
aji-174	312	4	,	,	PUNCT
aji-174	312	5	&	&	CCONJ
aji-174	312	6	mimura	mimura	NOUN
aji-174	312	7	,	,	PUNCT
aji-174	312	8	t.	t.	PROPN
aji-174	312	9	(	(	PUNCT
aji-174	312	10	2024	2024	NUM
aji-174	312	11	)	)	PUNCT
aji-174	312	12	.	.	PUNCT
aji-174	313	1	epigenetic	epigenetic	ADJ
aji-174	313	2	dysregulation	dysregulation	NOUN
aji-174	313	3	in	in	ADP
aji-174	313	4	the	the	DET
aji-174	313	5	pathogenesis	pathogenesis	NOUN
aji-174	313	6	of	of	ADP
aji-174	313	7	systemic	systemic	ADJ
aji-174	313	8	lupus	lupus	PROPN
aji-174	313	9	erythematosus	erythematosus	PROPN
aji-174	313	10	.	.	PUNCT
aji-174	314	1	international	international	ADJ
aji-174	314	2	journal	journal	NOUN
aji-174	314	3	of	of	ADP
aji-174	314	4	molecular	molecular	ADJ
aji-174	314	5	sciences	science	NOUN
aji-174	314	6	,	,	PUNCT
aji-174	314	7	25(2	25(2	NUM
aji-174	314	8	)	)	PUNCT
aji-174	314	9	,	,	PUNCT
aji-174	314	10	1019	1019	NUM
aji-174	314	11	.	.	PUNCT
aji-174	315	1	arneth	arneth	PROPN
aji-174	315	2	,	,	PUNCT
aji-174	315	3	b.	b.	PROPN
aji-174	315	4	(	(	PUNCT
aji-174	315	5	2024	2024	NUM
aji-174	315	6	)	)	PUNCT
aji-174	315	7	.	.	PUNCT
aji-174	316	1	genes	gene	NOUN
aji-174	316	2	,	,	PUNCT
aji-174	316	3	gene	gene	NOUN
aji-174	316	4	loci	locus	NOUN
aji-174	316	5	,	,	PUNCT
aji-174	316	6	and	and	CCONJ
aji-174	316	7	their	their	PRON
aji-174	316	8	impacts	impact	NOUN
aji-174	316	9	on	on	ADP
aji-174	316	10	the	the	DET
aji-174	316	11	immune	immune	ADJ
aji-174	316	12	system	system	NOUN
aji-174	316	13	in	in	ADP
aji-174	316	14	the	the	DET
aji-174	316	15	development	development	NOUN
aji-174	316	16	of	of	ADP
aji-174	316	17	multiple	multiple	ADJ
aji-174	316	18	sclerosis	sclerosis	NOUN
aji-174	316	19	:	:	PUNCT
aji-174	316	20	a	a	DET
aji-174	316	21	systematic	systematic	ADJ
aji-174	316	22	review	review	NOUN
aji-174	316	23	.	.	PUNCT
aji-174	317	1	international	international	ADJ
aji-174	317	2	journal	journal	NOUN
aji-174	317	3	of	of	ADP
aji-174	317	4	molecular	molecular	ADJ
aji-174	317	5	sciences	science	NOUN
aji-174	317	6	,	,	PUNCT
aji-174	317	7	25(23	25(23	NOUN
aji-174	317	8	)	)	PUNCT
aji-174	317	9	,	,	PUNCT
aji-174	317	10	12906	12906	NUM
aji-174	317	11	.	.	PUNCT
aji-174	318	1	ates	ates	PROPN
aji-174	318	2	,	,	PUNCT
aji-174	318	3	i.	i.	PROPN
aji-174	318	4	,	,	PUNCT
aji-174	318	5	terzi	terzi	NOUN
aji-174	318	6	,	,	PUNCT
aji-174	318	7	u.	u.	NOUN
aji-174	318	8	,	,	PUNCT
aji-174	318	9	suzen	suzen	ADJ
aji-174	318	10	,	,	PUNCT
aji-174	318	11	s.	s.	PROPN
aji-174	318	12	,	,	PUNCT
aji-174	318	13	&	&	CCONJ
aji-174	318	14	irham	irham	PROPN
aji-174	318	15	,	,	PUNCT
aji-174	318	16	l.	l.	PROPN
aji-174	318	17	m.	m.	PROPN
aji-174	318	18	(	(	PUNCT
aji-174	318	19	2025	2025	NUM
aji-174	318	20	)	)	PUNCT
aji-174	318	21	.	.	PUNCT
aji-174	319	1	an	an	DET
aji-174	319	2	overview	overview	NOUN
aji-174	319	3	on	on	ADP
aji-174	319	4	sjögren	sjögren	PROPN
aji-174	319	5	’s	’s	PART
aji-174	319	6	ajibola	ajibola	PROPN
aji-174	319	7	and	and	CCONJ
aji-174	319	8	ayodele	ayodele	PROPN
aji-174	319	9	;	;	PUNCT
aji-174	319	10	asian	asian	PROPN
aji-174	319	11	j.	j.	PROPN
aji-174	319	12	immunol	immunol	PROPN
aji-174	319	13	.	.	PROPN
aji-174	319	14	,	,	PUNCT
aji-174	319	15	vol	vol	NOUN
aji-174	319	16	.	.	PROPN
aji-174	319	17	8	8	NUM
aji-174	319	18	,	,	PUNCT
aji-174	319	19	no	no	INTJ
aji-174	319	20	.	.	NOUN
aji-174	319	21	1	1	NUM
aji-174	319	22	,	,	PUNCT
aji-174	319	23	pp	pp	ADJ
aji-174	319	24	.	.	PUNCT
aji-174	320	1	230	230	NUM
aji-174	320	2	-	-	SYM
aji-174	320	3	241	241	NUM
aji-174	320	4	,	,	PUNCT
aji-174	320	5	2025	2025	NUM
aji-174	320	6	;	;	PUNCT
aji-174	320	7	article	article	NOUN
aji-174	320	8	no.aji.144830	no.aji.144830	NOUN
aji-174	320	9	239	239	NUM
aji-174	320	10	syndrome	syndrome	NOUN
aji-174	320	11	and	and	CCONJ
aji-174	320	12	systemic	systemic	ADJ
aji-174	320	13	lupus	lupus	PROPN
aji-174	320	14	erythematosus	erythematosus	NOUN
aji-174	320	15	’	'	PUNCT
aji-174	320	16	genetics	genetic	NOUN
aji-174	320	17	.	.	PUNCT
aji-174	321	1	toxicology	toxicology	NOUN
aji-174	321	2	research	research	NOUN
aji-174	321	3	,	,	PUNCT
aji-174	321	4	14(1	14(1	NUM
aji-174	321	5	)	)	PUNCT
aji-174	321	6	,	,	PUNCT
aji-174	321	7	tfae194	tfae194	PROPN
aji-174	321	8	.	.	PROPN
aji-174	321	9	ausserwinkler	ausserwinkler	NOUN
aji-174	321	10	,	,	PUNCT
aji-174	321	11	m.	m.	NOUN
aji-174	321	12	,	,	PUNCT
aji-174	321	13	gensluckner	gensluckner	NOUN
aji-174	321	14	,	,	PUNCT
aji-174	321	15	s.	s.	PROPN
aji-174	321	16	,	,	PUNCT
aji-174	321	17	voelkerer	voelkerer	NOUN
aji-174	321	18	,	,	PUNCT
aji-174	321	19	a.	a.	PROPN
aji-174	321	20	,	,	PUNCT
aji-174	321	21	thiel	thiel	PROPN
aji-174	321	22	,	,	PUNCT
aji-174	321	23	j.	j.	PROPN
aji-174	321	24	,	,	PUNCT
aji-174	321	25	neumann	neumann	PROPN
aji-174	321	26	,	,	PUNCT
aji-174	321	27	h.	h.	PROPN
aji-174	321	28	j.	j.	PROPN
aji-174	321	29	,	,	PUNCT
aji-174	321	30	flamm	flamm	PROPN
aji-174	321	31	,	,	PUNCT
aji-174	321	32	m.	m.	NOUN
aji-174	321	33	,	,	PUNCT
aji-174	321	34	...	...	PUNCT
aji-174	321	35	&	&	CCONJ
aji-174	321	36	wernly	wernly	ADV
aji-174	321	37	,	,	PUNCT
aji-174	321	38	b.	b.	PROPN
aji-174	321	39	(	(	PUNCT
aji-174	321	40	2025	2025	NUM
aji-174	321	41	)	)	PUNCT
aji-174	321	42	.	.	PUNCT
aji-174	322	1	genetic	genetic	ADJ
aji-174	322	2	relationship	relationship	NOUN
aji-174	322	3	between	between	ADP
aji-174	322	4	rheumatoid	rheumatoid	NOUN
aji-174	322	5	arthritis	arthritis	NOUN
aji-174	322	6	and	and	CCONJ
aji-174	322	7	cardiovascular	cardiovascular	ADJ
aji-174	322	8	diseases	disease	NOUN
aji-174	322	9	:	:	PUNCT
aji-174	322	10	a	a	DET
aji-174	322	11	systematic	systematic	ADJ
aji-174	322	12	review	review	NOUN
aji-174	322	13	of	of	ADP
aji-174	322	14	mendelian	mendelian	ADJ
aji-174	322	15	randomization	randomization	NOUN
aji-174	322	16	studies	study	NOUN
aji-174	322	17	.	.	PUNCT
aji-174	323	1	wiener	wiener	NOUN
aji-174	323	2	klinische	klinische	NOUN
aji-174	323	3	wochenschrift	wochenschrift	NOUN
aji-174	323	4	,	,	PUNCT
aji-174	323	5	137(9	137(9	NUM
aji-174	323	6	)	)	PUNCT
aji-174	323	7	,	,	PUNCT
aji-174	323	8	272–278	272–278	NUM
aji-174	323	9	.	.	PUNCT
aji-174	324	1	bannazadeh	bannazadeh	PROPN
aji-174	324	2	baghi	baghi	PROPN
aji-174	324	3	,	,	PUNCT
aji-174	324	4	h.	h.	PROPN
aji-174	324	5	,	,	PUNCT
aji-174	324	6	bayat	bayat	PROPN
aji-174	324	7	,	,	PUNCT
aji-174	324	8	m.	m.	NOUN
aji-174	324	9	,	,	PUNCT
aji-174	324	10	mehrasa	mehrasa	NOUN
aji-174	324	11	,	,	PUNCT
aji-174	324	12	p.	p.	PROPN
aji-174	324	13	,	,	PUNCT
aji-174	324	14	alavi	alavi	PROPN
aji-174	324	15	,	,	PUNCT
aji-174	324	16	s.	s.	PROPN
aji-174	324	17	m.	m.	PROPN
aji-174	324	18	a.	a.	PROPN
aji-174	324	19	,	,	PUNCT
aji-174	324	20	lotfalizadeh	lotfalizadeh	NOUN
aji-174	324	21	,	,	PUNCT
aji-174	324	22	m.	m.	PROPN
aji-174	324	23	h.	h.	PROPN
aji-174	324	24	,	,	PUNCT
aji-174	324	25	memar	memar	PROPN
aji-174	324	26	,	,	PUNCT
aji-174	324	27	m.	m.	NOUN
aji-174	324	28	y.	y.	PROPN
aji-174	324	29	,	,	PUNCT
aji-174	324	30	...	...	PUNCT
aji-174	324	31	&	&	CCONJ
aji-174	324	32	mirzaei	mirzaei	PROPN
aji-174	324	33	,	,	PUNCT
aji-174	324	34	h.	h.	PROPN
aji-174	324	35	(	(	PUNCT
aji-174	324	36	2024	2024	NUM
aji-174	324	37	)	)	PUNCT
aji-174	324	38	.	.	PUNCT
aji-174	325	1	regulatory	regulatory	ADJ
aji-174	325	2	role	role	NOUN
aji-174	325	3	of	of	ADP
aji-174	325	4	micrornas	microrna	NOUN
aji-174	325	5	in	in	ADP
aji-174	325	6	virus	virus	NOUN
aji-174	325	7	-	-	PUNCT
aji-174	325	8	mediated	mediate	VERB
aji-174	325	9	inflammation	inflammation	NOUN
aji-174	325	10	.	.	PUNCT
aji-174	326	1	journal	journal	PROPN
aji-174	326	2	of	of	ADP
aji-174	326	3	inflammation	inflammation	NOUN
aji-174	326	4	,	,	PUNCT
aji-174	326	5	21(1	21(1	NUM
aji-174	326	6	)	)	PUNCT
aji-174	326	7	,	,	PUNCT
aji-174	326	8	43	43	NUM
aji-174	326	9	.	.	PUNCT
aji-174	327	1	barnes	barnes	PROPN
aji-174	327	2	,	,	PUNCT
aji-174	327	3	b.	b.	PROPN
aji-174	327	4	m.	m.	PROPN
aji-174	327	5	,	,	PUNCT
aji-174	327	6	shyne	shyne	PROPN
aji-174	327	7	,	,	PUNCT
aji-174	327	8	a.	a.	PROPN
aji-174	327	9	,	,	PUNCT
aji-174	327	10	gunn	gunn	PROPN
aji-174	327	11	,	,	PUNCT
aji-174	327	12	d.	d.	PROPN
aji-174	327	13	a.	a.	PROPN
aji-174	327	14	,	,	PUNCT
aji-174	327	15	griffiths	griffiths	PROPN
aji-174	327	16	,	,	PUNCT
aji-174	327	17	c.	c.	PROPN
aji-174	327	18	e.	e.	PROPN
aji-174	327	19	,	,	PUNCT
aji-174	327	20	&	&	CCONJ
aji-174	327	21	watson	watson	PROPN
aji-174	327	22	,	,	PUNCT
aji-174	327	23	r.	r.	PROPN
aji-174	327	24	e.	e.	PROPN
aji-174	327	25	(	(	PUNCT
aji-174	327	26	2024	2024	NUM
aji-174	327	27	)	)	PUNCT
aji-174	327	28	.	.	PUNCT
aji-174	328	1	epigenetics	epigenetic	NOUN
aji-174	328	2	and	and	CCONJ
aji-174	328	3	ultraviolet	ultraviolet	ADJ
aji-174	328	4	radiation	radiation	NOUN
aji-174	328	5	:	:	PUNCT
aji-174	328	6	implications	implication	NOUN
aji-174	328	7	for	for	ADP
aji-174	328	8	skin	skin	NOUN
aji-174	328	9	ageing	ageing	NOUN
aji-174	328	10	and	and	CCONJ
aji-174	328	11	carcinogenesis	carcinogenesis	NOUN
aji-174	328	12	.	.	PUNCT
aji-174	329	1	skin	skin	NOUN
aji-174	329	2	health	health	NOUN
aji-174	329	3	and	and	CCONJ
aji-174	329	4	disease	disease	NOUN
aji-174	329	5	,	,	PUNCT
aji-174	329	6	4(6	4(6	NUM
aji-174	329	7	)	)	PUNCT
aji-174	329	8	,	,	PUNCT
aji-174	329	9	e410	e410	PROPN
aji-174	329	10	.	.	PUNCT
aji-174	330	1	chen	chen	PROPN
aji-174	330	2	,	,	PUNCT
aji-174	330	3	g.	g.	PROPN
aji-174	330	4	,	,	PUNCT
aji-174	330	5	zhang	zhang	PROPN
aji-174	330	6	,	,	PUNCT
aji-174	330	7	l.	l.	PROPN
aji-174	330	8	,	,	PUNCT
aji-174	330	9	wang	wang	PROPN
aji-174	330	10	,	,	PUNCT
aji-174	330	11	r.	r.	PROPN
aji-174	330	12	,	,	PUNCT
aji-174	330	13	&	&	CCONJ
aji-174	330	14	xie	xie	PROPN
aji-174	330	15	,	,	PUNCT
aji-174	330	16	z.	z.	PROPN
aji-174	330	17	(	(	PUNCT
aji-174	330	18	2024	2024	NUM
aji-174	330	19	)	)	PUNCT
aji-174	330	20	.	.	PUNCT
aji-174	331	1	histone	histone	NOUN
aji-174	331	2	methylation	methylation	NOUN
aji-174	331	3	in	in	ADP
aji-174	331	4	epstein	epstein	PROPN
aji-174	331	5	–	–	PUNCT
aji-174	331	6	barr	barr	PROPN
aji-174	331	7	virusassociated	virusassociate	VERB
aji-174	331	8	diseases	disease	NOUN
aji-174	331	9	.	.	PUNCT
aji-174	332	1	epigenomics	epigenomic	NOUN
aji-174	332	2	,	,	PUNCT
aji-174	332	3	16(11	16(11	NUM
aji-174	332	4	–	–	PUNCT
aji-174	332	5	12	12	NUM
aji-174	332	6	)	)	PUNCT
aji-174	332	7	,	,	PUNCT
aji-174	332	8	865–877	865–877	NUM
aji-174	332	9	.	.	PUNCT
aji-174	333	1	chen	chen	PROPN
aji-174	333	2	,	,	PUNCT
aji-174	333	3	y.	y.	PROPN
aji-174	333	4	,	,	PUNCT
aji-174	333	5	guo	guo	PROPN
aji-174	333	6	,	,	PUNCT
aji-174	333	7	p.	p.	PROPN
aji-174	333	8	,	,	PUNCT
aji-174	333	9	&	&	CCONJ
aji-174	333	10	dong	dong	PROPN
aji-174	333	11	,	,	PUNCT
aji-174	333	12	z.	z.	PROPN
aji-174	333	13	(	(	PUNCT
aji-174	333	14	2024	2024	NUM
aji-174	333	15	)	)	PUNCT
aji-174	333	16	.	.	PUNCT
aji-174	334	1	the	the	DET
aji-174	334	2	role	role	NOUN
aji-174	334	3	of	of	ADP
aji-174	334	4	histone	histone	NOUN
aji-174	334	5	acetylation	acetylation	NOUN
aji-174	334	6	in	in	ADP
aji-174	334	7	transcriptional	transcriptional	ADJ
aji-174	334	8	regulation	regulation	NOUN
aji-174	334	9	and	and	CCONJ
aji-174	334	10	seed	seed	NOUN
aji-174	334	11	development	development	NOUN
aji-174	334	12	.	.	PUNCT
aji-174	335	1	plant	plant	NOUN
aji-174	335	2	physiology	physiology	NOUN
aji-174	335	3	,	,	PUNCT
aji-174	335	4	194(4	194(4	NUM
aji-174	335	5	)	)	PUNCT
aji-174	335	6	,	,	PUNCT
aji-174	335	7	1962–1979	1962–1979	NUM
aji-174	335	8	.	.	PUNCT
aji-174	336	1	deng	deng	PROPN
aji-174	336	2	,	,	PUNCT
aji-174	336	3	t.	t.	PROPN
aji-174	336	4	,	,	PUNCT
aji-174	336	5	wang	wang	PROPN
aji-174	336	6	,	,	PUNCT
aji-174	336	7	z.	z.	PROPN
aji-174	336	8	,	,	PUNCT
aji-174	336	9	geng	geng	PROPN
aji-174	336	10	,	,	PUNCT
aji-174	336	11	q.	q.	PROPN
aji-174	336	12	,	,	PUNCT
aji-174	336	13	wang	wang	PROPN
aji-174	336	14	,	,	PUNCT
aji-174	336	15	z.	z.	PROPN
aji-174	336	16	,	,	PUNCT
aji-174	336	17	jiao	jiao	PROPN
aji-174	336	18	,	,	PUNCT
aji-174	336	19	y.	y.	PROPN
aji-174	336	20	,	,	PUNCT
aji-174	336	21	diao	diao	PROPN
aji-174	336	22	,	,	PUNCT
aji-174	336	23	w.	w.	PROPN
aji-174	336	24	,	,	PUNCT
aji-174	336	25	&	&	CCONJ
aji-174	336	26	xiao	xiao	PROPN
aji-174	336	27	,	,	PUNCT
aji-174	336	28	c.	c.	PROPN
aji-174	336	29	(	(	PUNCT
aji-174	336	30	2024	2024	NUM
aji-174	336	31	)	)	PUNCT
aji-174	336	32	.	.	PUNCT
aji-174	337	1	methylation	methylation	NOUN
aji-174	337	2	of	of	ADP
aji-174	337	3	t	t	PROPN
aji-174	337	4	and	and	CCONJ
aji-174	337	5	b	b	PROPN
aji-174	337	6	lymphocytes	lymphocyte	NOUN
aji-174	337	7	in	in	ADP
aji-174	337	8	autoimmune	autoimmune	ADJ
aji-174	337	9	rheumatic	rheumatic	ADJ
aji-174	337	10	diseases	disease	NOUN
aji-174	337	11	.	.	PUNCT
aji-174	338	1	clinical	clinical	ADJ
aji-174	338	2	reviews	review	NOUN
aji-174	338	3	in	in	ADP
aji-174	338	4	allergy	allergy	PROPN
aji-174	338	5	&	&	CCONJ
aji-174	338	6	immunology	immunology	NOUN
aji-174	338	7	,	,	PUNCT
aji-174	338	8	66(3	66(3	NOUN
aji-174	338	9	)	)	PUNCT
aji-174	338	10	,	,	PUNCT
aji-174	338	11	401–422	401–422	NUM
aji-174	338	12	.	.	PUNCT
aji-174	339	1	elbahrawi	elbahrawi	PROPN
aji-174	339	2	,	,	PUNCT
aji-174	339	3	r.	r.	PROPN
aji-174	339	4	,	,	PUNCT
aji-174	339	5	aljoudi	aljoudi	ADJ
aji-174	339	6	,	,	PUNCT
aji-174	339	7	s.	s.	PROPN
aji-174	339	8	,	,	PUNCT
aji-174	339	9	rabeh	rabeh	NOUN
aji-174	339	10	,	,	PUNCT
aji-174	339	11	n.	n.	NOUN
aji-174	339	12	,	,	PUNCT
aji-174	339	13	dimassi	dimassi	ADJ
aji-174	339	14	,	,	PUNCT
aji-174	339	15	z.	z.	PROPN
aji-174	339	16	,	,	PUNCT
aji-174	339	17	alhosani	alhosani	PROPN
aji-174	339	18	,	,	PUNCT
aji-174	339	19	k.	k.	PROPN
aji-174	339	20	m.	m.	PROPN
aji-174	339	21	,	,	PUNCT
aji-174	339	22	&	&	CCONJ
aji-174	339	23	hamdan	hamdan	PROPN
aji-174	339	24	,	,	PUNCT
aji-174	339	25	h.	h.	PROPN
aji-174	339	26	(	(	PUNCT
aji-174	339	27	2024	2024	NUM
aji-174	339	28	)	)	PUNCT
aji-174	339	29	.	.	PUNCT
aji-174	340	1	epigenetics	epigenetic	NOUN
aji-174	340	2	:	:	PUNCT
aji-174	340	3	implication	implication	NOUN
aji-174	340	4	on	on	ADP
aji-174	340	5	multiple	multiple	ADJ
aji-174	340	6	sclerosis	sclerosis	NOUN
aji-174	340	7	.	.	PUNCT
aji-174	341	1	in	in	ADP
aji-174	341	2	exploring	explore	VERB
aji-174	341	3	the	the	DET
aji-174	341	4	effects	effect	NOUN
aji-174	341	5	of	of	ADP
aji-174	341	6	diet	diet	NOUN
aji-174	341	7	on	on	ADP
aji-174	341	8	the	the	DET
aji-174	341	9	development	development	NOUN
aji-174	341	10	and	and	CCONJ
aji-174	341	11	prognosis	prognosis	NOUN
aji-174	341	12	of	of	ADP
aji-174	341	13	multiple	multiple	ADJ
aji-174	341	14	sclerosis	sclerosis	NOUN
aji-174	341	15	(	(	PUNCT
aji-174	341	16	ms	ms	PROPN
aji-174	341	17	)	)	PUNCT
aji-174	341	18	(	(	PUNCT
aji-174	341	19	pp	pp	PROPN
aji-174	341	20	.	.	PUNCT
aji-174	341	21	207	207	NUM
aji-174	341	22	–	–	PUNCT
aji-174	341	23	218	218	NUM
aji-174	341	24	)	)	PUNCT
aji-174	341	25	.	.	PUNCT
aji-174	342	1	singapore	singapore	PROPN
aji-174	342	2	:	:	PUNCT
aji-174	342	3	springer	springer	NOUN
aji-174	342	4	nature	nature	PROPN
aji-174	342	5	singapore	singapore	PROPN
aji-174	342	6	.	.	PUNCT
aji-174	343	1	enayati	enayati	PROPN
aji-174	343	2	,	,	PUNCT
aji-174	343	3	s.	s.	PROPN
aji-174	343	4	,	,	PUNCT
aji-174	343	5	moharamoghli	moharamoghli	NOUN
aji-174	343	6	,	,	PUNCT
aji-174	343	7	m.	m.	NOUN
aji-174	343	8	,	,	PUNCT
aji-174	343	9	farazmand	farazmand	PROPN
aji-174	343	10	,	,	PUNCT
aji-174	343	11	a.	a.	NOUN
aji-174	343	12	,	,	PUNCT
aji-174	343	13	hassan	hassan	PROPN
aji-174	343	14	-	-	PUNCT
aji-174	343	15	zadeh	zadeh	PROPN
aji-174	343	16	,	,	PUNCT
aji-174	343	17	v.	v.	PROPN
aji-174	343	18	,	,	PUNCT
aji-174	343	19	poursani	poursani	NOUN
aji-174	343	20	,	,	PUNCT
aji-174	343	21	s.	s.	PROPN
aji-174	343	22	,	,	PUNCT
aji-174	343	23	madreseh	madreseh	PROPN
aji-174	343	24	,	,	PUNCT
aji-174	343	25	e.	e.	PROPN
aji-174	343	26	,	,	PUNCT
aji-174	343	27	...	...	PUNCT
aji-174	343	28	&	&	CCONJ
aji-174	343	29	mahmoudi	mahmoudi	NOUN
aji-174	343	30	,	,	PUNCT
aji-174	343	31	m.	m.	NOUN
aji-174	343	32	(	(	PUNCT
aji-174	343	33	2024	2024	NUM
aji-174	343	34	)	)	PUNCT
aji-174	343	35	.	.	PUNCT
aji-174	344	1	upregulated	upregulate	VERB
aji-174	344	2	gene	gene	NOUN
aji-174	344	3	expression	expression	NOUN
aji-174	344	4	of	of	ADP
aji-174	344	5	histone	histone	NOUN
aji-174	344	6	deacetylases	deacetylase	NOUN
aji-174	344	7	(	(	PUNCT
aji-174	344	8	hdac	hdac	NOUN
aji-174	344	9	)	)	PUNCT
aji-174	344	10	1	1	NUM
aji-174	344	11	,	,	PUNCT
aji-174	344	12	2	2	NUM
aji-174	344	13	,	,	PUNCT
aji-174	344	14	and	and	CCONJ
aji-174	344	15	11	11	NUM
aji-174	344	16	in	in	ADP
aji-174	344	17	peripheral	peripheral	ADJ
aji-174	344	18	blood	blood	NOUN
aji-174	344	19	mononuclear	mononuclear	ADJ
aji-174	344	20	cells	cell	NOUN
aji-174	344	21	of	of	ADP
aji-174	344	22	rheumatoid	rheumatoid	VERB
aji-174	344	23	arthritis	arthritis	NOUN
aji-174	344	24	patients	patient	NOUN
aji-174	344	25	.	.	PUNCT
aji-174	345	1	journal	journal	NOUN
aji-174	345	2	of	of	ADP
aji-174	345	3	cellular	cellular	ADJ
aji-174	345	4	immunology	immunology	NOUN
aji-174	345	5	,	,	PUNCT
aji-174	345	6	6(4	6(4	NOUN
aji-174	345	7	)	)	PUNCT
aji-174	345	8	,	,	PUNCT
aji-174	345	9	188–195	188–195	NUM
aji-174	345	10	.	.	PUNCT
aji-174	345	11	fisse	fisse	PROPN
aji-174	345	12	,	,	PUNCT
aji-174	345	13	a.	a.	PROPN
aji-174	345	14	l.	l.	PROPN
aji-174	345	15	,	,	PUNCT
aji-174	345	16	motte	motte	PROPN
aji-174	345	17	,	,	PUNCT
aji-174	345	18	j.	j.	PROPN
aji-174	345	19	,	,	PUNCT
aji-174	345	20	kalliopi	kalliopi	PROPN
aji-174	345	21	,	,	PUNCT
aji-174	345	22	a.	a.	PROPN
aji-174	345	23	p.	p.	PROPN
aji-174	345	24	d.	d.	PROPN
aji-174	345	25	,	,	PUNCT
aji-174	345	26	&	&	CCONJ
aji-174	345	27	pitarokoili	pitarokoili	PROPN
aji-174	345	28	,	,	PUNCT
aji-174	345	29	m.	m.	PROPN
aji-174	345	30	d.	d.	PROPN
aji-174	345	31	(	(	PUNCT
aji-174	345	32	2024	2024	NUM
aji-174	345	33	)	)	PUNCT
aji-174	345	34	.	.	PUNCT
aji-174	346	1	influence	influence	NOUN
aji-174	346	2	of	of	ADP
aji-174	346	3	the	the	DET
aji-174	346	4	short	short	ADJ
aji-174	346	5	-	-	PUNCT
aji-174	346	6	chain	chain	NOUN
aji-174	346	7	fatty	fatty	NOUN
aji-174	346	8	acid	acid	NOUN
aji-174	346	9	propionic	propionic	ADJ
aji-174	346	10	acid	acid	NOUN
aji-174	346	11	on	on	ADP
aji-174	346	12	the	the	DET
aji-174	346	13	peripheral	peripheral	ADJ
aji-174	346	14	immune	immune	ADJ
aji-174	346	15	regulation	regulation	NOUN
aji-174	346	16	in	in	ADP
aji-174	346	17	the	the	DET
aji-174	346	18	context	context	NOUN
aji-174	346	19	of	of	ADP
aji-174	346	20	chronic	chronic	ADJ
aji-174	346	21	inflammatory	inflammatory	ADJ
aji-174	346	22	demyelinating	demyelinate	VERB
aji-174	346	23	polyneuropathy	polyneuropathy	NOUN
aji-174	346	24	(	(	PUNCT
aji-174	346	25	cidp	cidp	NOUN
aji-174	346	26	)	)	PUNCT
aji-174	346	27	.	.	PUNCT
aji-174	347	1	gibson	gibson	PROPN
aji-174	347	2	,	,	PUNCT
aji-174	347	3	f.	f.	PROPN
aji-174	347	4	,	,	PUNCT
aji-174	347	5	hanly	hanly	ADV
aji-174	347	6	,	,	PUNCT
aji-174	347	7	a.	a.	NOUN
aji-174	347	8	,	,	PUNCT
aji-174	347	9	grbic	grbic	ADJ
aji-174	347	10	,	,	PUNCT
aji-174	347	11	n.	n.	NOUN
aji-174	347	12	,	,	PUNCT
aji-174	347	13	grunberg	grunberg	PROPN
aji-174	347	14	,	,	PUNCT
aji-174	347	15	n.	n.	NOUN
aji-174	347	16	,	,	PUNCT
aji-174	347	17	wu	wu	PROPN
aji-174	347	18	,	,	PUNCT
aji-174	347	19	m.	m.	NOUN
aji-174	347	20	,	,	PUNCT
aji-174	347	21	collard	collard	NOUN
aji-174	347	22	,	,	PUNCT
aji-174	347	23	m.	m.	NOUN
aji-174	347	24	,	,	PUNCT
aji-174	347	25	&	&	CCONJ
aji-174	347	26	alani	alani	PROPN
aji-174	347	27	,	,	PUNCT
aji-174	347	28	r.	r.	PROPN
aji-174	347	29	m.	m.	PROPN
aji-174	347	30	(	(	PUNCT
aji-174	347	31	2022	2022	NUM
aji-174	347	32	)	)	PUNCT
aji-174	347	33	.	.	PUNCT
aji-174	348	1	epigenetic	epigenetic	ADJ
aji-174	348	2	dysregulation	dysregulation	NOUN
aji-174	348	3	in	in	ADP
aji-174	348	4	autoimmune	autoimmune	ADJ
aji-174	348	5	and	and	CCONJ
aji-174	348	6	inflammatory	inflammatory	ADJ
aji-174	348	7	skin	skin	NOUN
aji-174	348	8	diseases	disease	NOUN
aji-174	348	9	.	.	PUNCT
aji-174	349	1	clinical	clinical	ADJ
aji-174	349	2	reviews	review	NOUN
aji-174	349	3	in	in	ADP
aji-174	349	4	allergy	allergy	PROPN
aji-174	349	5	&	&	CCONJ
aji-174	349	6	immunology	immunology	NOUN
aji-174	349	7	,	,	PUNCT
aji-174	349	8	63(3	63(3	NUM
aji-174	349	9	)	)	PUNCT
aji-174	349	10	,	,	PUNCT
aji-174	349	11	447–471	447–471	NUM
aji-174	349	12	.	.	PUNCT
aji-174	350	1	https://link.springer.com/article/10.1007/s1	https://link.springer.com/article/10.1007/s1	PROPN
aji-174	350	2	2016	2016	NUM
aji-174	350	3	-	-	PUNCT
aji-174	350	4	022	022	NUM
aji-174	350	5	-	-	PUNCT
aji-174	350	6	08956	08956	NUM
aji-174	350	7	-	-	PUNCT
aji-174	350	8	8	8	NUM
aji-174	350	9	goodarzi	goodarzi	NOUN
aji-174	350	10	,	,	PUNCT
aji-174	350	11	g.	g.	PROPN
aji-174	350	12	,	,	PUNCT
aji-174	350	13	tehrani	tehrani	PROPN
aji-174	350	14	,	,	PUNCT
aji-174	350	15	s.	s.	PROPN
aji-174	350	16	s.	s.	PROPN
aji-174	350	17	,	,	PUNCT
aji-174	350	18	fana	fana	PROPN
aji-174	350	19	,	,	PUNCT
aji-174	350	20	s.	s.	PROPN
aji-174	350	21	e.	e.	PROPN
aji-174	350	22	,	,	PUNCT
aji-174	350	23	saleknezhad	saleknezhad	VERB
aji-174	350	24	,	,	PUNCT
aji-174	350	25	n.	n.	NOUN
aji-174	350	26	,	,	PUNCT
aji-174	350	27	panahi	panahi	NOUN
aji-174	350	28	,	,	PUNCT
aji-174	350	29	g.	g.	PROPN
aji-174	350	30	,	,	PUNCT
aji-174	350	31	rayatpisheh	rayatpisheh	ADJ
aji-174	350	32	,	,	PUNCT
aji-174	350	33	m.	m.	NOUN
aji-174	350	34	,	,	PUNCT
aji-174	350	35	&	&	CCONJ
aji-174	350	36	anushiravani	anushiravani	PROPN
aji-174	350	37	,	,	PUNCT
aji-174	350	38	a.	a.	NOUN
aji-174	350	39	(	(	PUNCT
aji-174	350	40	2025	2025	NUM
aji-174	350	41	)	)	PUNCT
aji-174	350	42	.	.	PUNCT
aji-174	351	1	evaluation	evaluation	NOUN
aji-174	351	2	of	of	ADP
aji-174	351	3	microrna-29a	microrna-29a	PROPN
aji-174	351	4	expression	expression	NOUN
aji-174	351	5	and	and	CCONJ
aji-174	351	6	dipeptidyl	dipeptidyl	NOUN
aji-174	351	7	-	-	PUNCT
aji-174	351	8	peptidase	peptidase	NOUN
aji-174	351	9	4	4	NUM
aji-174	351	10	level	level	NOUN
aji-174	351	11	in	in	ADP
aji-174	351	12	ulcerative	ulcerative	ADJ
aji-174	351	13	colitis	colitis	NOUN
aji-174	351	14	patients	patient	NOUN
aji-174	351	15	.	.	PUNCT
aji-174	352	1	acta	acta	PROPN
aji-174	352	2	biochimica	biochimica	PROPN
aji-174	352	3	iranica	iranica	PROPN
aji-174	352	4	.	.	PUNCT
aji-174	353	1	hahn	hahn	PROPN
aji-174	353	2	,	,	PUNCT
aji-174	353	3	j.	j.	PROPN
aji-174	353	4	,	,	PUNCT
aji-174	353	5	ding	ding	PROPN
aji-174	353	6	,	,	PUNCT
aji-174	353	7	s.	s.	PROPN
aji-174	353	8	,	,	PUNCT
aji-174	353	9	i	i	PRON
aji-174	353	10	m	m	PROPN
aji-174	353	11	,	,	PUNCT
aji-174	353	12	j.	j.	PROPN
aji-174	353	13	,	,	PUNCT
aji-174	353	14	harimoto	harimoto	PROPN
aji-174	353	15	,	,	PUNCT
aji-174	353	16	t.	t.	PROPN
aji-174	353	17	,	,	PUNCT
aji-174	353	18	leong	leong	PROPN
aji-174	353	19	,	,	PUNCT
aji-174	353	20	k.	k.	PROPN
aji-174	353	21	w.	w.	PROPN
aji-174	353	22	,	,	PUNCT
aji-174	353	23	&	&	CCONJ
aji-174	353	24	danino	danino	PROPN
aji-174	353	25	,	,	PUNCT
aji-174	353	26	t.	t.	PROPN
aji-174	353	27	(	(	PUNCT
aji-174	353	28	2024	2024	NUM
aji-174	353	29	)	)	PUNCT
aji-174	353	30	.	.	PUNCT
aji-174	354	1	bacterial	bacterial	ADJ
aji-174	354	2	therapies	therapy	NOUN
aji-174	354	3	at	at	ADP
aji-174	354	4	the	the	DET
aji-174	354	5	interface	interface	NOUN
aji-174	354	6	of	of	ADP
aji-174	354	7	synthetic	synthetic	ADJ
aji-174	354	8	biology	biology	NOUN
aji-174	354	9	and	and	CCONJ
aji-174	354	10	nanomedicine	nanomedicine	NOUN
aji-174	354	11	.	.	PUNCT
aji-174	355	1	nature	nature	NOUN
aji-174	355	2	reviews	review	VERB
aji-174	355	3	bioengineering	bioengineering	NOUN
aji-174	355	4	,	,	PUNCT
aji-174	355	5	2(2	2(2	NUM
aji-174	355	6	)	)	PUNCT
aji-174	355	7	,	,	PUNCT
aji-174	355	8	120–135	120–135	NUM
aji-174	355	9	.	.	PUNCT
aji-174	356	1	harris	harris	PROPN
aji-174	356	2	,	,	PUNCT
aji-174	356	3	j.	j.	PROPN
aji-174	356	4	,	,	PUNCT
aji-174	356	5	mayran	mayran	PROPN
aji-174	356	6	,	,	PUNCT
aji-174	356	7	a.	a.	NOUN
aji-174	356	8	,	,	PUNCT
aji-174	356	9	gouhier	gouhier	NOUN
aji-174	356	10	,	,	PUNCT
aji-174	356	11	a.	a.	PROPN
aji-174	356	12	,	,	PUNCT
aji-174	356	13	gauthier	gauthier	PROPN
aji-174	356	14	,	,	PUNCT
aji-174	356	15	y.	y.	PROPN
aji-174	356	16	,	,	PUNCT
aji-174	356	17	sleiman	sleiman	NOUN
aji-174	356	18	,	,	PUNCT
aji-174	356	19	n.	n.	PROPN
aji-174	356	20	h.	h.	PROPN
aji-174	356	21	,	,	PUNCT
aji-174	356	22	merabet	merabet	PROPN
aji-174	356	23	,	,	PUNCT
aji-174	356	24	s.	s.	PROPN
aji-174	356	25	,	,	PUNCT
aji-174	356	26	...	...	PUNCT
aji-174	356	27	&	&	CCONJ
aji-174	356	28	drouin	drouin	PROPN
aji-174	356	29	,	,	PUNCT
aji-174	356	30	j.	j.	PROPN
aji-174	356	31	(	(	PUNCT
aji-174	356	32	2025	2025	NUM
aji-174	356	33	)	)	PUNCT
aji-174	356	34	.	.	PUNCT
aji-174	357	1	dual	dual	ADJ
aji-174	357	2	dna	dna	PROPN
aji-174	357	3	demethylation	demethylation	NOUN
aji-174	357	4	mechanisms	mechanism	NOUN
aji-174	357	5	implement	implement	VERB
aji-174	357	6	epigenetic	epigenetic	ADJ
aji-174	357	7	memory	memory	NOUN
aji-174	357	8	driven	drive	VERB
aji-174	357	9	by	by	ADP
aji-174	357	10	the	the	DET
aji-174	357	11	pioneer	pioneer	NOUN
aji-174	357	12	factor	factor	NOUN
aji-174	357	13	pax7	pax7	PROPN
aji-174	357	14	.	.	PUNCT
aji-174	358	1	science	science	NOUN
aji-174	358	2	advances	advance	NOUN
aji-174	358	3	,	,	PUNCT
aji-174	358	4	11(20	11(20	NUM
aji-174	358	5	)	)	PUNCT
aji-174	358	6	,	,	PUNCT
aji-174	358	7	eadu6632	eadu6632	PROPN
aji-174	358	8	.	.	PUNCT
aji-174	359	1	jay	jay	PROPN
aji-174	359	2	,	,	PUNCT
aji-174	359	3	a.	a.	PROPN
aji-174	359	4	,	,	PUNCT
aji-174	359	5	pondevida	pondevida	PROPN
aji-174	359	6	,	,	PUNCT
aji-174	359	7	c.	c.	PROPN
aji-174	359	8	m.	m.	PROPN
aji-174	359	9	,	,	PUNCT
aji-174	359	10	&	&	CCONJ
aji-174	359	11	vahedi	vahedi	PROPN
aji-174	359	12	,	,	PUNCT
aji-174	359	13	g.	g.	PROPN
aji-174	359	14	(	(	PUNCT
aji-174	359	15	2025	2025	NUM
aji-174	359	16	)	)	PUNCT
aji-174	359	17	.	.	PUNCT
aji-174	360	1	the	the	DET
aji-174	360	2	epigenetic	epigenetic	ADJ
aji-174	360	3	landscape	landscape	NOUN
aji-174	360	4	of	of	ADP
aji-174	360	5	fate	fate	ADJ
aji-174	360	6	decisions	decision	NOUN
aji-174	360	7	in	in	ADP
aji-174	360	8	t	t	NOUN
aji-174	360	9	cells	cell	NOUN
aji-174	360	10	.	.	PUNCT
aji-174	361	1	nature	nature	NOUN
aji-174	361	2	immunology	immunology	NOUN
aji-174	361	3	,	,	PUNCT
aji-174	361	4	1–13	1–13	PROPN
aji-174	361	5	.	.	PUNCT
aji-174	362	1	kaszycki	kaszycki	PROPN
aji-174	362	2	,	,	PUNCT
aji-174	362	3	j.	j.	PROPN
aji-174	362	4	,	,	PUNCT
aji-174	362	5	&	&	CCONJ
aji-174	362	6	kim	kim	PROPN
aji-174	362	7	,	,	PUNCT
aji-174	362	8	m.	m.	NOUN
aji-174	362	9	(	(	PUNCT
aji-174	362	10	2025	2025	NUM
aji-174	362	11	)	)	PUNCT
aji-174	362	12	.	.	PUNCT
aji-174	363	1	epigenetic	epigenetic	ADJ
aji-174	363	2	regulation	regulation	NOUN
aji-174	363	3	of	of	ADP
aji-174	363	4	transcription	transcription	NOUN
aji-174	363	5	factors	factor	NOUN
aji-174	363	6	involved	involve	VERB
aji-174	363	7	in	in	ADP
aji-174	363	8	nlrp3	nlrp3	ADJ
aji-174	363	9	inflammasome	inflammasome	NOUN
aji-174	363	10	and	and	CCONJ
aji-174	363	11	nf	nf	NOUN
aji-174	363	12	-	-	PUNCT
aji-174	363	13	κb	κb	NOUN
aji-174	363	14	signaling	signal	VERB
aji-174	363	15	pathways	pathway	NOUN
aji-174	363	16	.	.	PUNCT
aji-174	364	1	frontiers	frontier	NOUN
aji-174	364	2	in	in	ADP
aji-174	364	3	immunology	immunology	NOUN
aji-174	364	4	,	,	PUNCT
aji-174	364	5	16	16	NUM
aji-174	364	6	,	,	PUNCT
aji-174	364	7	1529756	1529756	NUM
aji-174	364	8	.	.	PUNCT
aji-174	365	1	khan	khan	PROPN
aji-174	365	2	,	,	PUNCT
aji-174	365	3	a.	a.	PROPN
aji-174	365	4	,	,	PUNCT
aji-174	365	5	mazumder	mazumder	NOUN
aji-174	365	6	,	,	PUNCT
aji-174	365	7	a.	a.	NOUN
aji-174	365	8	,	,	PUNCT
aji-174	365	9	pentela	pentela	PROPN
aji-174	365	10	,	,	PUNCT
aji-174	365	11	b.	b.	PROPN
aji-174	365	12	,	,	PUNCT
aji-174	365	13	mishra	mishra	PROPN
aji-174	365	14	,	,	PUNCT
aji-174	365	15	r.	r.	PROPN
aji-174	365	16	,	,	PUNCT
aji-174	365	17	&	&	CCONJ
aji-174	365	18	singh	singh	PROPN
aji-174	365	19	,	,	PUNCT
aji-174	365	20	s.	s.	PROPN
aji-174	365	21	k.	k.	PROPN
aji-174	365	22	(	(	PUNCT
aji-174	365	23	2024	2024	NUM
aji-174	365	24	)	)	PUNCT
aji-174	365	25	.	.	PUNCT
aji-174	366	1	the	the	DET
aji-174	366	2	ability	ability	NOUN
aji-174	366	3	of	of	ADP
aji-174	366	4	indigenous	indigenous	ADJ
aji-174	366	5	plants	plant	NOUN
aji-174	366	6	in	in	ADP
aji-174	366	7	alleviating	alleviate	VERB
aji-174	366	8	rheumatoid	rheumatoid	NOUN
aji-174	366	9	arthritis	arthritis	NOUN
aji-174	366	10	:	:	PUNCT
aji-174	366	11	a	a	DET
aji-174	366	12	comprehensive	comprehensive	ADJ
aji-174	366	13	review	review	NOUN
aji-174	366	14	.	.	PUNCT
aji-174	367	1	current	current	ADJ
aji-174	367	2	rheumatology	rheumatology	NOUN
aji-174	367	3	reviews	review	NOUN
aji-174	367	4	.	.	PUNCT
aji-174	368	1	khokhar	khokhar	PROPN
aji-174	368	2	,	,	PUNCT
aji-174	368	3	m.	m.	NOUN
aji-174	368	4	,	,	PUNCT
aji-174	368	5	dey	dey	PROPN
aji-174	368	6	,	,	PUNCT
aji-174	368	7	s.	s.	PROPN
aji-174	368	8	,	,	PUNCT
aji-174	368	9	tomo	tomo	PROPN
aji-174	368	10	,	,	PUNCT
aji-174	368	11	s.	s.	PROPN
aji-174	368	12	,	,	PUNCT
aji-174	368	13	jaremko	jaremko	PROPN
aji-174	368	14	,	,	PUNCT
aji-174	368	15	m.	m.	NOUN
aji-174	368	16	,	,	PUNCT
aji-174	368	17	emwas	emwas	PROPN
aji-174	368	18	,	,	PUNCT
aji-174	368	19	a.	a.	PROPN
aji-174	368	20	h.	h.	PROPN
aji-174	368	21	,	,	PUNCT
aji-174	368	22	&	&	CCONJ
aji-174	368	23	pandey	pandey	PROPN
aji-174	368	24	,	,	PUNCT
aji-174	368	25	r.	r.	PROPN
aji-174	368	26	k.	k.	PROPN
aji-174	368	27	(	(	PUNCT
aji-174	368	28	2024	2024	NUM
aji-174	368	29	)	)	PUNCT
aji-174	368	30	.	.	PUNCT
aji-174	369	1	unveiling	unveil	VERB
aji-174	369	2	novel	novel	ADJ
aji-174	369	3	drug	drug	NOUN
aji-174	369	4	targets	target	NOUN
aji-174	369	5	and	and	CCONJ
aji-174	369	6	emerging	emerge	VERB
aji-174	369	7	therapies	therapy	NOUN
aji-174	369	8	for	for	ADP
aji-174	369	9	rheumatoid	rheumatoid	NOUN
aji-174	369	10	arthritis	arthritis	NOUN
aji-174	369	11	:	:	PUNCT
aji-174	369	12	a	a	DET
aji-174	369	13	comprehensive	comprehensive	ADJ
aji-174	369	14	review	review	NOUN
aji-174	369	15	.	.	PUNCT
aji-174	370	1	acs	acs	PROPN
aji-174	370	2	pharmacology	pharmacology	PROPN
aji-174	370	3	&	&	CCONJ
aji-174	370	4	translational	translational	ADJ
aji-174	370	5	science	science	NOUN
aji-174	370	6	,	,	PUNCT
aji-174	370	7	7(6	7(6	NUM
aji-174	370	8	)	)	PUNCT
aji-174	370	9	,	,	PUNCT
aji-174	370	10	1664–1693	1664–1693	NUM
aji-174	370	11	.	.	PUNCT
aji-174	371	1	kong	kong	PROPN
aji-174	371	2	,	,	PUNCT
aji-174	371	3	j.	j.	PROPN
aji-174	371	4	,	,	PUNCT
aji-174	371	5	lyu	lyu	PROPN
aji-174	371	6	,	,	PUNCT
aji-174	371	7	h.	h.	PROPN
aji-174	371	8	,	,	PUNCT
aji-174	371	9	ouyang	ouyang	PROPN
aji-174	371	10	,	,	PUNCT
aji-174	371	11	q.	q.	PROPN
aji-174	371	12	,	,	PUNCT
aji-174	371	13	shi	shi	PROPN
aji-174	371	14	,	,	PUNCT
aji-174	371	15	h.	h.	PROPN
aji-174	371	16	,	,	PUNCT
aji-174	371	17	zhang	zhang	PROPN
aji-174	371	18	,	,	PUNCT
aji-174	371	19	r.	r.	PROPN
aji-174	371	20	,	,	PUNCT
aji-174	371	21	xiao	xiao	PROPN
aji-174	371	22	,	,	PUNCT
aji-174	371	23	s.	s.	PROPN
aji-174	371	24	,	,	PUNCT
aji-174	371	25	...	...	PUNCT
aji-174	371	26	&	&	CCONJ
aji-174	371	27	tang	tang	PROPN
aji-174	371	28	,	,	PUNCT
aji-174	371	29	j.	j.	PROPN
aji-174	371	30	(	(	PUNCT
aji-174	371	31	2024	2024	NUM
aji-174	371	32	)	)	PUNCT
aji-174	371	33	.	.	PUNCT
aji-174	372	1	insights	insight	NOUN
aji-174	372	2	into	into	ADP
aji-174	372	3	the	the	DET
aji-174	372	4	roles	role	NOUN
aji-174	372	5	of	of	ADP
aji-174	372	6	epigenetic	epigenetic	ADJ
aji-174	372	7	modifications	modification	NOUN
aji-174	372	8	in	in	ADP
aji-174	372	9	ferroptosis	ferroptosis	NOUN
aji-174	372	10	.	.	PUNCT
aji-174	373	1	biology	biology	NOUN
aji-174	373	2	,	,	PUNCT
aji-174	373	3	13(2	13(2	PROPN
aji-174	373	4	)	)	PUNCT
aji-174	373	5	,	,	PUNCT
aji-174	373	6	122	122	NUM
aji-174	373	7	.	.	PUNCT
aji-174	374	1	kwon	kwon	PROPN
aji-174	374	2	,	,	PUNCT
aji-174	374	3	g.	g.	PROPN
aji-174	374	4	,	,	PUNCT
aji-174	374	5	park	park	NOUN
aji-174	374	6	,	,	PUNCT
aji-174	374	7	y.	y.	PROPN
aji-174	374	8	,	,	PUNCT
aji-174	374	9	kang	kang	PROPN
aji-174	374	10	,	,	PUNCT
aji-174	374	11	k.	k.	PROPN
aji-174	374	12	,	,	PUNCT
aji-174	374	13	&	&	CCONJ
aji-174	374	14	kang	kang	PROPN
aji-174	374	15	,	,	PUNCT
aji-174	374	16	k.	k.	PROPN
aji-174	374	17	(	(	PUNCT
aji-174	374	18	2024	2024	NUM
aji-174	374	19	)	)	PUNCT
aji-174	374	20	.	.	PUNCT
aji-174	375	1	selective	selective	ADJ
aji-174	375	2	epigenetic	epigenetic	ADJ
aji-174	375	3	regulation	regulation	NOUN
aji-174	375	4	of	of	ADP
aji-174	375	5	ifn	ifn	PROPN
aji-174	375	6	-	-	PUNCT
aji-174	375	7	γ	γ	NOUN
aji-174	375	8	signature	signature	NOUN
aji-174	375	9	genes	gene	NOUN
aji-174	375	10	by	by	ADP
aji-174	375	11	jak	jak	PROPN
aji-174	375	12	inhibitor	inhibitor	NOUN
aji-174	375	13	in	in	ADP
aji-174	375	14	inflammatory	inflammatory	ADJ
aji-174	375	15	diseases	disease	NOUN
aji-174	375	16	.	.	PUNCT
aji-174	376	1	biorxiv	biorxiv	NOUN
aji-174	376	2	,	,	PUNCT
aji-174	376	3	2024–08	2024–08	NUM
aji-174	376	4	.	.	PUNCT
aji-174	377	1	li	li	PROPN
aji-174	377	2	,	,	PUNCT
aji-174	377	3	c.	c.	PROPN
aji-174	377	4	,	,	PUNCT
aji-174	377	5	gu	gu	PROPN
aji-174	377	6	,	,	PUNCT
aji-174	377	7	s.	s.	PROPN
aji-174	377	8	,	,	PUNCT
aji-174	377	9	zhang	zhang	PROPN
aji-174	377	10	,	,	PUNCT
aji-174	377	11	y.	y.	PROPN
aji-174	377	12	,	,	PUNCT
aji-174	377	13	zhang	zhang	PROPN
aji-174	377	14	,	,	PUNCT
aji-174	377	15	z.	z.	PROPN
aji-174	377	16	,	,	PUNCT
aji-174	377	17	wang	wang	PROPN
aji-174	377	18	,	,	PUNCT
aji-174	377	19	j.	j.	PROPN
aji-174	377	20	,	,	PUNCT
aji-174	377	21	gao	gao	PROPN
aji-174	377	22	,	,	PUNCT
aji-174	377	23	t.	t.	PROPN
aji-174	377	24	,	,	PUNCT
aji-174	377	25	...	...	PUNCT
aji-174	377	26	&	&	CCONJ
aji-174	377	27	chen	chen	PROPN
aji-174	377	28	,	,	PUNCT
aji-174	377	29	y.	y.	PROPN
aji-174	377	30	(	(	PUNCT
aji-174	377	31	2025	2025	NUM
aji-174	377	32	)	)	PUNCT
aji-174	377	33	.	.	PUNCT
aji-174	378	1	histone	histone	NOUN
aji-174	378	2	deacetylase	deacetylase	VERB
aji-174	378	3	in	in	ADP
aji-174	378	4	inflammatory	inflammatory	ADJ
aji-174	378	5	bowel	bowel	NOUN
aji-174	378	6	disease	disease	NOUN
aji-174	378	7	:	:	PUNCT
aji-174	378	8	novel	novel	ADJ
aji-174	378	9	insights	insight	NOUN
aji-174	378	10	.	.	PUNCT
aji-174	379	1	therapeutic	therapeutic	ADJ
aji-174	379	2	https://link.springer.com/article/10.1007/s12016-022-08956-8	https://link.springer.com/article/10.1007/s12016-022-08956-8	PROPN
aji-174	379	3	https://link.springer.com/article/10.1007/s12016-022-08956-8	https://link.springer.com/article/10.1007/s12016-022-08956-8	ADV
aji-174	379	4	ajibola	ajibola	PROPN
aji-174	379	5	and	and	CCONJ
aji-174	379	6	ayodele	ayodele	PROPN
aji-174	379	7	;	;	PUNCT
aji-174	379	8	asian	asian	PROPN
aji-174	379	9	j.	j.	PROPN
aji-174	379	10	immunol	immunol	PROPN
aji-174	379	11	.	.	PROPN
aji-174	379	12	,	,	PUNCT
aji-174	379	13	vol	vol	NOUN
aji-174	379	14	.	.	PROPN
aji-174	379	15	8	8	NUM
aji-174	379	16	,	,	PUNCT
aji-174	379	17	no	no	INTJ
aji-174	379	18	.	.	NOUN
aji-174	379	19	1	1	NUM
aji-174	379	20	,	,	PUNCT
aji-174	379	21	pp	pp	ADJ
aji-174	379	22	.	.	PUNCT
aji-174	380	1	230	230	NUM
aji-174	380	2	-	-	SYM
aji-174	380	3	241	241	NUM
aji-174	380	4	,	,	PUNCT
aji-174	380	5	2025	2025	NUM
aji-174	380	6	;	;	PUNCT
aji-174	380	7	article	article	NOUN
aji-174	380	8	no.aji.144830	no.aji.144830	NOUN
aji-174	380	9	240	240	NUM
aji-174	380	10	advances	advance	NOUN
aji-174	380	11	in	in	ADP
aji-174	380	12	gastroenterology	gastroenterology	NOUN
aji-174	380	13	,	,	PUNCT
aji-174	380	14	18	18	NUM
aji-174	380	15	,	,	PUNCT
aji-174	380	16	17562848251318833	17562848251318833	NUM
aji-174	380	17	.	.	PUNCT
aji-174	381	1	lim	lim	PROPN
aji-174	381	2	,	,	PUNCT
aji-174	381	3	e.	e.	PROPN
aji-174	381	4	y.	y.	PROPN
aji-174	381	5	,	,	PUNCT
aji-174	381	6	&	&	CCONJ
aji-174	381	7	kim	kim	PROPN
aji-174	381	8	,	,	PUNCT
aji-174	381	9	g.	g.	PROPN
aji-174	381	10	d.	d.	PROPN
aji-174	381	11	(	(	PUNCT
aji-174	381	12	2024	2024	NUM
aji-174	381	13	)	)	PUNCT
aji-174	381	14	.	.	PUNCT
aji-174	382	1	particulate	particulate	NOUN
aji-174	382	2	matter	matter	ADV
aji-174	382	3	-	-	PUNCT
aji-174	382	4	induced	induced	ADJ
aji-174	382	5	emerging	emerge	VERB
aji-174	382	6	health	health	NOUN
aji-174	382	7	effects	effect	NOUN
aji-174	382	8	associated	associate	VERB
aji-174	382	9	with	with	ADP
aji-174	382	10	oxidative	oxidative	ADJ
aji-174	382	11	stress	stress	NOUN
aji-174	382	12	and	and	CCONJ
aji-174	382	13	inflammation	inflammation	NOUN
aji-174	382	14	.	.	PUNCT
aji-174	383	1	antioxidants	antioxidant	NOUN
aji-174	383	2	,	,	PUNCT
aji-174	383	3	13(10	13(10	NUM
aji-174	383	4	)	)	PUNCT
aji-174	383	5	,	,	PUNCT
aji-174	383	6	1256	1256	NUM
aji-174	383	7	.	.	PUNCT
aji-174	384	1	lin	lin	PROPN
aji-174	384	2	,	,	PUNCT
aji-174	384	3	h.	h.	PROPN
aji-174	384	4	y.	y.	PROPN
aji-174	384	5	,	,	PUNCT
aji-174	384	6	lee	lee	PROPN
aji-174	384	7	,	,	PUNCT
aji-174	384	8	c.	c.	PROPN
aji-174	384	9	l.	l.	PROPN
aji-174	384	10	,	,	PUNCT
aji-174	384	11	tu	tu	PROPN
aji-174	384	12	,	,	PUNCT
aji-174	384	13	y.	y.	PROPN
aji-174	384	14	r.	r.	PROPN
aji-174	384	15	,	,	PUNCT
aji-174	384	16	chang	chang	PROPN
aji-174	384	17	,	,	PUNCT
aji-174	384	18	y.	y.	PROPN
aji-174	384	19	h.	h.	PROPN
aji-174	384	20	,	,	PUNCT
aji-174	384	21	niu	niu	PROPN
aji-174	384	22	,	,	PUNCT
aji-174	384	23	d.	d.	PROPN
aji-174	384	24	m.	m.	PROPN
aji-174	384	25	,	,	PUNCT
aji-174	384	26	chang	chang	PROPN
aji-174	384	27	,	,	PUNCT
aji-174	384	28	c.	c.	PROPN
aji-174	384	29	y.	y.	PROPN
aji-174	384	30	,	,	PUNCT
aji-174	384	31	...	...	PUNCT
aji-174	384	32	&	&	CCONJ
aji-174	384	33	lin	lin	PROPN
aji-174	384	34	,	,	PUNCT
aji-174	384	35	s.	s.	PROPN
aji-174	384	36	p.	p.	PROPN
aji-174	384	37	(	(	PUNCT
aji-174	384	38	2024	2024	NUM
aji-174	384	39	)	)	PUNCT
aji-174	384	40	.	.	PUNCT
aji-174	385	1	quantitative	quantitative	ADJ
aji-174	385	2	dna	dna	PROPN
aji-174	385	3	methylation	methylation	NOUN
aji-174	385	4	analysis	analysis	NOUN
aji-174	385	5	and	and	CCONJ
aji-174	385	6	epigenotype	epigenotype	NOUN
aji-174	385	7	-	-	PUNCT
aji-174	385	8	phenotype	phenotype	NOUN
aji-174	385	9	correlations	correlation	NOUN
aji-174	385	10	in	in	ADP
aji-174	385	11	taiwanese	taiwanese	ADJ
aji-174	385	12	patients	patient	NOUN
aji-174	385	13	with	with	ADP
aji-174	385	14	silver	silver	NOUN
aji-174	385	15	–	–	PUNCT
aji-174	385	16	russell	russell	NOUN
aji-174	385	17	syndrome	syndrome	NOUN
aji-174	385	18	.	.	PUNCT
aji-174	386	1	international	international	ADJ
aji-174	386	2	journal	journal	PROPN
aji-174	386	3	of	of	ADP
aji-174	386	4	medical	medical	ADJ
aji-174	386	5	sciences	science	NOUN
aji-174	386	6	,	,	PUNCT
aji-174	386	7	21(1	21(1	NUM
aji-174	386	8	)	)	PUNCT
aji-174	386	9	,	,	PUNCT
aji-174	386	10	8	8	NUM
aji-174	386	11	.	.	PUNCT
aji-174	387	1	liu	liu	PROPN
aji-174	387	2	,	,	PUNCT
aji-174	387	3	x.	x.	PROPN
aji-174	387	4	,	,	PUNCT
aji-174	387	5	zhou	zhou	PROPN
aji-174	387	6	,	,	PUNCT
aji-174	387	7	s.	s.	PROPN
aji-174	387	8	,	,	PUNCT
aji-174	387	9	huang	huang	PROPN
aji-174	387	10	,	,	PUNCT
aji-174	387	11	m.	m.	NOUN
aji-174	387	12	,	,	PUNCT
aji-174	387	13	zhao	zhao	PROPN
aji-174	387	14	,	,	PUNCT
aji-174	387	15	m.	m.	NOUN
aji-174	387	16	,	,	PUNCT
aji-174	387	17	zhang	zhang	PROPN
aji-174	387	18	,	,	PUNCT
aji-174	387	19	w.	w.	PROPN
aji-174	387	20	,	,	PUNCT
aji-174	387	21	liu	liu	PROPN
aji-174	387	22	,	,	PUNCT
aji-174	387	23	q.	q.	PROPN
aji-174	387	24	,	,	PUNCT
aji-174	387	25	...	...	PUNCT
aji-174	387	26	&	&	CCONJ
aji-174	387	27	chen	chen	PROPN
aji-174	387	28	,	,	PUNCT
aji-174	387	29	x.	x.	PROPN
aji-174	387	30	(	(	PUNCT
aji-174	387	31	2024	2024	NUM
aji-174	387	32	)	)	PUNCT
aji-174	387	33	.	.	PUNCT
aji-174	388	1	dna	dna	PROPN
aji-174	388	2	methylation	methylation	NOUN
aji-174	388	3	and	and	CCONJ
aji-174	388	4	whole	whole	ADJ
aji-174	388	5	-	-	PUNCT
aji-174	388	6	genome	genome	NOUN
aji-174	388	7	transcription	transcription	NOUN
aji-174	388	8	analysis	analysis	NOUN
aji-174	388	9	in	in	ADP
aji-174	388	10	cd4	cd4	PROPN
aji-174	388	11	+	+	PROPN
aji-174	388	12	t	t	NOUN
aji-174	388	13	cells	cell	NOUN
aji-174	388	14	from	from	ADP
aji-174	388	15	systemic	systemic	ADJ
aji-174	388	16	lupus	lupus	PROPN
aji-174	388	17	erythematosus	erythematosus	PROPN
aji-174	388	18	patients	patient	NOUN
aji-174	388	19	with	with	ADP
aji-174	388	20	or	or	CCONJ
aji-174	388	21	without	without	ADP
aji-174	388	22	renal	renal	ADJ
aji-174	388	23	damage	damage	NOUN
aji-174	388	24	.	.	PUNCT
aji-174	389	1	clinical	clinical	ADJ
aji-174	389	2	epigenetics	epigenetic	NOUN
aji-174	389	3	,	,	PUNCT
aji-174	389	4	16(1	16(1	NUM
aji-174	389	5	)	)	PUNCT
aji-174	389	6	,	,	PUNCT
aji-174	389	7	98	98	NUM
aji-174	389	8	.	.	PUNCT
aji-174	390	1	mahurkar‐joshi	mahurkar‐joshi	PROPN
aji-174	390	2	,	,	PUNCT
aji-174	390	3	s.	s.	PROPN
aji-174	390	4	,	,	PUNCT
aji-174	390	5	thompson	thompson	PROPN
aji-174	390	6	,	,	PUNCT
aji-174	390	7	m.	m.	NOUN
aji-174	390	8	,	,	PUNCT
aji-174	390	9	villarruel	villarruel	PROPN
aji-174	390	10	,	,	PUNCT
aji-174	390	11	e.	e.	PROPN
aji-174	390	12	,	,	PUNCT
aji-174	390	13	lewis	lewis	PROPN
aji-174	390	14	,	,	PUNCT
aji-174	390	15	j.	j.	PROPN
aji-174	390	16	d.	d.	PROPN
aji-174	390	17	,	,	PUNCT
aji-174	390	18	lin	lin	PROPN
aji-174	390	19	,	,	PUNCT
aji-174	390	20	l.	l.	PROPN
aji-174	390	21	d.	d.	PROPN
aji-174	390	22	,	,	PUNCT
aji-174	390	23	farid	farid	PROPN
aji-174	390	24	,	,	PUNCT
aji-174	390	25	m.	m.	NOUN
aji-174	390	26	,	,	PUNCT
aji-174	390	27	...	...	PUNCT
aji-174	390	28	&	&	CCONJ
aji-174	390	29	chang	chang	PROPN
aji-174	390	30	,	,	PUNCT
aji-174	390	31	l.	l.	PROPN
aji-174	390	32	(	(	PUNCT
aji-174	390	33	2025	2025	NUM
aji-174	390	34	)	)	PUNCT
aji-174	390	35	.	.	PUNCT
aji-174	391	1	genome‐wide	genome‐wide	PROPN
aji-174	391	2	dna	dna	PROPN
aji-174	391	3	methylation	methylation	PROPN
aji-174	391	4	identifies	identify	VERB
aji-174	391	5	potential	potential	ADJ
aji-174	391	6	disease‐specific	disease‐specific	NOUN
aji-174	391	7	biomarkers	biomarker	NOUN
aji-174	391	8	and	and	CCONJ
aji-174	391	9	pathophysiologic	pathophysiologic	ADJ
aji-174	391	10	mechanisms	mechanism	NOUN
aji-174	391	11	in	in	ADP
aji-174	391	12	irritable	irritable	ADJ
aji-174	391	13	bowel	bowel	NOUN
aji-174	391	14	syndrome	syndrome	NOUN
aji-174	391	15	,	,	PUNCT
aji-174	391	16	inflammatory	inflammatory	ADJ
aji-174	391	17	bowel	bowel	NOUN
aji-174	391	18	disease	disease	NOUN
aji-174	391	19	,	,	PUNCT
aji-174	391	20	and	and	CCONJ
aji-174	391	21	celiac	celiac	ADJ
aji-174	391	22	disease	disease	NOUN
aji-174	391	23	.	.	PUNCT
aji-174	392	1	neurogastroenterology	neurogastroenterology	NOUN
aji-174	392	2	&	&	CCONJ
aji-174	392	3	motility	motility	NOUN
aji-174	392	4	,	,	PUNCT
aji-174	392	5	37(2	37(2	PROPN
aji-174	392	6	)	)	PUNCT
aji-174	392	7	,	,	PUNCT
aji-174	392	8	e14980	e14980	PROPN
aji-174	392	9	.	.	PUNCT
aji-174	393	1	mehta	mehta	PROPN
aji-174	393	2	,	,	PUNCT
aji-174	393	3	p.	p.	PROPN
aji-174	393	4	,	,	PUNCT
aji-174	393	5	&	&	CCONJ
aji-174	393	6	mazumder	mazumder	PROPN
aji-174	393	7	,	,	PUNCT
aji-174	393	8	s.	s.	PROPN
aji-174	393	9	(	(	PUNCT
aji-174	393	10	2025	2025	NUM
aji-174	393	11	)	)	PUNCT
aji-174	393	12	.	.	PUNCT
aji-174	394	1	mir-146a	mir-146a	PROPN
aji-174	394	2	is	be	AUX
aji-174	394	3	critical	critical	ADJ
aji-174	394	4	for	for	ADP
aji-174	394	5	orchestrating	orchestrate	VERB
aji-174	394	6	mycobacterium	mycobacterium	PROPN
aji-174	394	7	fortuitum	fortuitum	PROPN
aji-174	394	8	survival	survival	NOUN
aji-174	394	9	through	through	ADP
aji-174	394	10	antiinflammatory	antiinflammatory	NOUN
aji-174	394	11	and	and	CCONJ
aji-174	394	12	m2	m2	PROPN
aji-174	394	13	macrophage	macrophage	ADJ
aji-174	394	14	responses	response	NOUN
aji-174	394	15	in	in	ADP
aji-174	394	16	fish	fish	NOUN
aji-174	394	17	.	.	PUNCT
aji-174	395	1	fish	fish	NOUN
aji-174	395	2	&	&	CCONJ
aji-174	395	3	shellfish	shellfish	ADJ
aji-174	395	4	immunology	immunology	NOUN
aji-174	395	5	,	,	PUNCT
aji-174	395	6	161	161	NUM
aji-174	395	7	,	,	PUNCT
aji-174	395	8	110271	110271	NUM
aji-174	395	9	.	.	PUNCT
aji-174	396	1	nie	nie	PROPN
aji-174	396	2	,	,	PUNCT
aji-174	396	3	y.	y.	PROPN
aji-174	396	4	,	,	PUNCT
aji-174	396	5	song	song	NOUN
aji-174	396	6	,	,	PUNCT
aji-174	396	7	c.	c.	PROPN
aji-174	396	8	,	,	PUNCT
aji-174	396	9	huang	huang	PROPN
aji-174	396	10	,	,	PUNCT
aji-174	396	11	h.	h.	PROPN
aji-174	396	12	,	,	PUNCT
aji-174	396	13	mao	mao	PROPN
aji-174	396	14	,	,	PUNCT
aji-174	396	15	s.	s.	PROPN
aji-174	396	16	,	,	PUNCT
aji-174	396	17	ding	ding	PROPN
aji-174	396	18	,	,	PUNCT
aji-174	396	19	k.	k.	PROPN
aji-174	396	20	,	,	PUNCT
aji-174	396	21	&	&	CCONJ
aji-174	396	22	tang	tang	PROPN
aji-174	396	23	,	,	PUNCT
aji-174	396	24	h.	h.	PROPN
aji-174	396	25	(	(	PUNCT
aji-174	396	26	2024	2024	NUM
aji-174	396	27	)	)	PUNCT
aji-174	396	28	.	.	PUNCT
aji-174	397	1	chromatin	chromatin	NOUN
aji-174	397	2	modifiers	modifier	NOUN
aji-174	397	3	in	in	ADP
aji-174	397	4	human	human	ADJ
aji-174	397	5	disease	disease	NOUN
aji-174	397	6	:	:	PUNCT
aji-174	397	7	from	from	ADP
aji-174	397	8	functional	functional	ADJ
aji-174	397	9	roles	role	NOUN
aji-174	397	10	to	to	ADP
aji-174	397	11	regulatory	regulatory	ADJ
aji-174	397	12	mechanisms	mechanism	NOUN
aji-174	397	13	.	.	PUNCT
aji-174	398	1	molecular	molecular	ADJ
aji-174	398	2	biomedicine	biomedicine	NOUN
aji-174	398	3	,	,	PUNCT
aji-174	398	4	5(1	5(1	NUM
aji-174	398	5	)	)	PUNCT
aji-174	398	6	,	,	PUNCT
aji-174	398	7	12	12	NUM
aji-174	398	8	.	.	PUNCT
aji-174	399	1	prideaux	prideaux	PROPN
aji-174	399	2	,	,	PUNCT
aji-174	399	3	e.	e.	PROPN
aji-174	399	4	b.	b.	PROPN
aji-174	399	5	,	,	PUNCT
aji-174	399	6	boyle	boyle	PROPN
aji-174	399	7	,	,	PUNCT
aji-174	399	8	d.	d.	PROPN
aji-174	399	9	l.	l.	PROPN
aji-174	399	10	,	,	PUNCT
aji-174	399	11	choi	choi	PROPN
aji-174	399	12	,	,	PUNCT
aji-174	399	13	e.	e.	PROPN
aji-174	399	14	,	,	PUNCT
aji-174	399	15	buckner	buckner	PROPN
aji-174	399	16	,	,	PUNCT
aji-174	399	17	j.	j.	PROPN
aji-174	399	18	h.	h.	PROPN
aji-174	399	19	,	,	PUNCT
aji-174	399	20	robinson	robinson	PROPN
aji-174	399	21	,	,	PUNCT
aji-174	399	22	w.	w.	PROPN
aji-174	399	23	h.	h.	PROPN
aji-174	399	24	,	,	PUNCT
aji-174	399	25	holers	holer	NOUN
aji-174	399	26	,	,	PUNCT
aji-174	399	27	v.	v.	ADP
aji-174	399	28	m.	m.	NOUN
aji-174	399	29	,	,	PUNCT
aji-174	399	30	...	...	PUNCT
aji-174	399	31	&	&	CCONJ
aji-174	399	32	wang	wang	PROPN
aji-174	399	33	,	,	PUNCT
aji-174	399	34	w.	w.	PROPN
aji-174	399	35	(	(	PUNCT
aji-174	399	36	2024	2024	NUM
aji-174	399	37	)	)	PUNCT
aji-174	399	38	.	.	PUNCT
aji-174	400	1	epigenetic	epigenetic	ADJ
aji-174	400	2	trajectory	trajectory	NOUN
aji-174	400	3	predicts	predict	VERB
aji-174	400	4	development	development	NOUN
aji-174	400	5	of	of	ADP
aji-174	400	6	clinical	clinical	ADJ
aji-174	400	7	rheumatoid	rheumatoid	NOUN
aji-174	400	8	arthritis	arthritis	NOUN
aji-174	400	9	in	in	ADP
aji-174	400	10	acpa+	acpa+	PUNCT
aji-174	400	11	individuals	individual	NOUN
aji-174	400	12	:	:	PUNCT
aji-174	400	13	targeting	target	VERB
aji-174	400	14	immune	immune	ADJ
aji-174	400	15	responses	response	NOUN
aji-174	400	16	for	for	ADP
aji-174	400	17	prevention	prevention	NOUN
aji-174	400	18	of	of	ADP
aji-174	400	19	rheumatoid	rheumatoid	NOUN
aji-174	400	20	arthritis	arthritis	NOUN
aji-174	400	21	(	(	PUNCT
aji-174	400	22	tipra	tipra	NOUN
aji-174	400	23	)	)	PUNCT
aji-174	400	24	.	.	PUNCT
aji-174	401	1	biorxiv	biorxiv	NOUN
aji-174	401	2	,	,	PUNCT
aji-174	401	3	2024	2024	NUM
aji-174	401	4	-	-	SYM
aji-174	401	5	10	10	NUM
aji-174	401	6	.	.	PUNCT
aji-174	402	1	proaño	proaño	PROPN
aji-174	402	2	,	,	PUNCT
aji-174	402	3	a.	a.	NOUN
aji-174	402	4	,	,	PUNCT
aji-174	402	5	sarrion	sarrion	NOUN
aji-174	402	6	-	-	PUNCT
aji-174	402	7	perez	perez	PROPN
aji-174	402	8	,	,	PUNCT
aji-174	402	9	g.	g.	PROPN
aji-174	402	10	,	,	PUNCT
aji-174	402	11	bagan	bagan	PROPN
aji-174	402	12	,	,	PUNCT
aji-174	402	13	l.	l.	PROPN
aji-174	402	14	,	,	PUNCT
aji-174	402	15	&	&	CCONJ
aji-174	402	16	bagan	bagan	PROPN
aji-174	402	17	,	,	PUNCT
aji-174	402	18	j.	j.	PROPN
aji-174	402	19	(	(	PUNCT
aji-174	402	20	2025	2025	NUM
aji-174	402	21	)	)	PUNCT
aji-174	402	22	.	.	PUNCT
aji-174	403	1	genome	genome	NOUN
aji-174	403	2	-	-	PUNCT
aji-174	403	3	wide	wide	ADJ
aji-174	403	4	dna	dna	PROPN
aji-174	403	5	methylation	methylation	NOUN
aji-174	403	6	confirms	confirm	VERB
aji-174	403	7	oral	oral	ADJ
aji-174	403	8	squamous	squamous	ADJ
aji-174	403	9	cell	cell	NOUN
aji-174	403	10	carcinomas	carcinoma	NOUN
aji-174	403	11	in	in	ADP
aji-174	403	12	proliferative	proliferative	ADJ
aji-174	403	13	verrucous	verrucous	ADJ
aji-174	403	14	leukoplakia	leukoplakia	NOUN
aji-174	403	15	as	as	ADP
aji-174	403	16	a	a	DET
aji-174	403	17	distinct	distinct	ADJ
aji-174	403	18	oral	oral	ADJ
aji-174	403	19	cancer	cancer	NOUN
aji-174	403	20	subtype	subtype	NOUN
aji-174	403	21	:	:	PUNCT
aji-174	403	22	a	a	DET
aji-174	403	23	case	case	NOUN
aji-174	403	24	–	–	PUNCT
aji-174	403	25	control	control	NOUN
aji-174	403	26	study	study	NOUN
aji-174	403	27	.	.	PUNCT
aji-174	404	1	cancers	cancer	NOUN
aji-174	404	2	,	,	PUNCT
aji-174	404	3	17(2	17(2	NUM
aji-174	404	4	)	)	PUNCT
aji-174	404	5	,	,	PUNCT
aji-174	404	6	245	245	NUM
aji-174	404	7	.	.	PUNCT
aji-174	405	1	ribeiro	ribeiro	PROPN
aji-174	405	2	,	,	PUNCT
aji-174	405	3	a.	a.	PROPN
aji-174	405	4	a.	a.	PROPN
aji-174	405	5	,	,	PUNCT
aji-174	405	6	carvalho	carvalho	PROPN
aji-174	405	7	,	,	PUNCT
aji-174	405	8	l.	l.	PROPN
aji-174	405	9	m.	m.	PROPN
aji-174	405	10	,	,	PUNCT
aji-174	405	11	da	da	PROPN
aji-174	405	12	mota	mota	PROPN
aji-174	405	13	,	,	PUNCT
aji-174	405	14	j.	j.	PROPN
aji-174	405	15	c.	c.	PROPN
aji-174	405	16	,	,	PUNCT
aji-174	405	17	nonino	nonino	PROPN
aji-174	405	18	,	,	PUNCT
aji-174	405	19	c.	c.	PROPN
aji-174	405	20	b.	b.	PROPN
aji-174	405	21	,	,	PUNCT
aji-174	405	22	gualano	gualano	PROPN
aji-174	405	23	,	,	PUNCT
aji-174	405	24	b.	b.	PROPN
aji-174	405	25	,	,	PUNCT
aji-174	405	26	nunes	nunes	PROPN
aji-174	405	27	,	,	PUNCT
aji-174	405	28	j.	j.	PROPN
aji-174	405	29	a.	a.	PROPN
aji-174	405	30	,	,	PUNCT
aji-174	405	31	...	...	PUNCT
aji-174	405	32	&	&	CCONJ
aji-174	405	33	nicoletti	nicoletti	PROPN
aji-174	405	34	,	,	PUNCT
aji-174	405	35	c.	c.	PROPN
aji-174	405	36	f.	f.	PROPN
aji-174	405	37	(	(	PUNCT
aji-174	405	38	2024	2024	NUM
aji-174	405	39	)	)	PUNCT
aji-174	405	40	.	.	PUNCT
aji-174	406	1	diet	diet	PROPN
aji-174	406	2	,	,	PUNCT
aji-174	406	3	dna	dna	PROPN
aji-174	406	4	methylation	methylation	NOUN
aji-174	406	5	,	,	PUNCT
aji-174	406	6	and	and	CCONJ
aji-174	406	7	systemic	systemic	ADJ
aji-174	406	8	lupus	lupus	PROPN
aji-174	406	9	erythematosus	erythematosus	NOUN
aji-174	406	10	:	:	PUNCT
aji-174	406	11	evidence	evidence	NOUN
aji-174	406	12	and	and	CCONJ
aji-174	406	13	perspectives	perspective	NOUN
aji-174	406	14	focused	focus	VERB
aji-174	406	15	on	on	ADP
aji-174	406	16	personalized	personalized	ADJ
aji-174	406	17	nutrition	nutrition	NOUN
aji-174	406	18	.	.	PUNCT
aji-174	407	1	lifestyle	lifestyle	NOUN
aji-174	407	2	genomics	genomic	NOUN
aji-174	407	3	,	,	PUNCT
aji-174	407	4	17(1	17(1	NUM
aji-174	407	5	)	)	PUNCT
aji-174	407	6	,	,	PUNCT
aji-174	407	7	31–40	31–40	NUM
aji-174	407	8	.	.	PUNCT
aji-174	408	1	roy	roy	PROPN
aji-174	408	2	,	,	PUNCT
aji-174	408	3	s.	s.	PROPN
aji-174	408	4	,	,	PUNCT
aji-174	408	5	shanmugam	shanmugam	PROPN
aji-174	408	6	,	,	PUNCT
aji-174	408	7	g.	g.	PROPN
aji-174	408	8	,	,	PUNCT
aji-174	408	9	pradeep	pradeep	PROPN
aji-174	408	10	,	,	PUNCT
aji-174	408	11	r.	r.	PROPN
aji-174	408	12	,	,	PUNCT
aji-174	408	13	george	george	PROPN
aji-174	408	14	,	,	PUNCT
aji-174	408	15	m.	m.	NOUN
aji-174	408	16	,	,	PUNCT
aji-174	408	17	&	&	CCONJ
aji-174	408	18	sarkar	sarkar	PROPN
aji-174	408	19	,	,	PUNCT
aji-174	408	20	k.	k.	PROPN
aji-174	408	21	(	(	PUNCT
aji-174	408	22	2025	2025	NUM
aji-174	408	23	)	)	PUNCT
aji-174	408	24	.	.	PUNCT
aji-174	409	1	epigenetic	epigenetic	ADJ
aji-174	409	2	control	control	NOUN
aji-174	409	3	of	of	ADP
aji-174	409	4	t	t	PROPN
aji-174	409	5	helper	helper	NOUN
aji-174	409	6	cells	cell	NOUN
aji-174	409	7	differentiation	differentiation	NOUN
aji-174	409	8	:	:	PUNCT
aji-174	409	9	a	a	DET
aji-174	409	10	mechanistic	mechanistic	ADJ
aji-174	409	11	insight	insight	NOUN
aji-174	409	12	into	into	ADP
aji-174	409	13	the	the	DET
aji-174	409	14	association	association	NOUN
aji-174	409	15	between	between	ADP
aji-174	409	16	acute	acute	PROPN
aji-174	409	17	leukemia	leukemia	NOUN
aji-174	409	18	and	and	CCONJ
aji-174	409	19	coronary	coronary	ADJ
aji-174	409	20	artery	artery	NOUN
aji-174	409	21	disease	disease	NOUN
aji-174	409	22	.	.	PUNCT
aji-174	410	1	medical	medical	ADJ
aji-174	410	2	oncology	oncology	NOUN
aji-174	410	3	,	,	PUNCT
aji-174	410	4	42(7	42(7	PROPN
aji-174	410	5	)	)	PUNCT
aji-174	410	6	,	,	PUNCT
aji-174	410	7	272	272	NUM
aji-174	410	8	.	.	PUNCT
aji-174	411	1	royo	royo	PROPN
aji-174	411	2	,	,	PUNCT
aji-174	411	3	m.	m.	NOUN
aji-174	411	4	,	,	PUNCT
aji-174	411	5	joseph	joseph	PROPN
aji-174	411	6	-	-	PUNCT
aji-174	411	7	mullol	mullol	PROPN
aji-174	411	8	,	,	PUNCT
aji-174	411	9	b.	b.	PROPN
aji-174	411	10	,	,	PUNCT
aji-174	411	11	sandoval	sandoval	PROPN
aji-174	411	12	,	,	PUNCT
aji-174	411	13	s.	s.	PROPN
aji-174	411	14	,	,	PUNCT
aji-174	411	15	moline	moline	PROPN
aji-174	411	16	,	,	PUNCT
aji-174	411	17	t.	t.	PROPN
aji-174	411	18	,	,	PUNCT
aji-174	411	19	sole	sole	ADJ
aji-174	411	20	,	,	PUNCT
aji-174	411	21	c.	c.	PROPN
aji-174	411	22	,	,	PUNCT
aji-174	411	23	&	&	CCONJ
aji-174	411	24	cortes	cortes	PROPN
aji-174	411	25	-	-	PROPN
aji-174	411	26	hernandez	hernandez	PROPN
aji-174	411	27	,	,	PUNCT
aji-174	411	28	j.	j.	PROPN
aji-174	411	29	(	(	PUNCT
aji-174	411	30	2025	2025	NUM
aji-174	411	31	)	)	PUNCT
aji-174	411	32	.	.	PUNCT
aji-174	412	1	integrative	integrative	ADJ
aji-174	412	2	mirna	mirna	PROPN
aji-174	412	3	-	-	PUNCT
aji-174	412	4	mrna	mrna	PROPN
aji-174	412	5	profiling	profiling	NOUN
aji-174	412	6	uncovers	uncover	NOUN
aji-174	412	7	mechanisms	mechanism	NOUN
aji-174	412	8	of	of	ADP
aji-174	412	9	belimumab	belimumab	NOUN
aji-174	412	10	action	action	NOUN
aji-174	412	11	in	in	ADP
aji-174	412	12	systemic	systemic	ADJ
aji-174	412	13	lupus	lupus	PROPN
aji-174	412	14	erythematosus	erythematosus	PROPN
aji-174	412	15	.	.	PUNCT
aji-174	413	1	frontiers	frontier	NOUN
aji-174	413	2	in	in	ADP
aji-174	413	3	immunology	immunology	NOUN
aji-174	413	4	,	,	PUNCT
aji-174	413	5	16	16	NUM
aji-174	413	6	,	,	PUNCT
aji-174	413	7	1553971	1553971	NUM
aji-174	413	8	.	.	PUNCT
aji-174	414	1	sarre	sarre	PROPN
aji-174	414	2	,	,	PUNCT
aji-174	414	3	l.	l.	PROPN
aji-174	414	4	a.	a.	PROPN
aji-174	414	5	,	,	PUNCT
aji-174	414	6	gastellou	gastellou	PROPN
aji-174	414	7	peralta	peralta	PROPN
aji-174	414	8	,	,	PUNCT
aji-174	414	9	g.	g.	PROPN
aji-174	414	10	a.	a.	PROPN
aji-174	414	11	,	,	PUNCT
aji-174	414	12	romero	romero	PROPN
aji-174	414	13	charria	charria	PROPN
aji-174	414	14	,	,	PUNCT
aji-174	414	15	p.	p.	NOUN
aji-174	414	16	,	,	PUNCT
aji-174	414	17	ovchinnikov	ovchinnikov	ADJ
aji-174	414	18	,	,	PUNCT
aji-174	414	19	v.	v.	ADJ
aji-174	414	20	,	,	PUNCT
aji-174	414	21	&	&	CCONJ
aji-174	414	22	de	de	PROPN
aji-174	414	23	mendoza	mendoza	PROPN
aji-174	414	24	,	,	PUNCT
aji-174	414	25	a.	a.	NOUN
aji-174	414	26	(	(	PUNCT
aji-174	414	27	2025	2025	NUM
aji-174	414	28	)	)	PUNCT
aji-174	414	29	.	.	PUNCT
aji-174	415	1	repressive	repressive	ADJ
aji-174	415	2	cytosine	cytosine	NOUN
aji-174	415	3	methylation	methylation	NOUN
aji-174	415	4	is	be	AUX
aji-174	415	5	a	a	DET
aji-174	415	6	marker	marker	NOUN
aji-174	415	7	of	of	ADP
aji-174	415	8	viral	viral	ADJ
aji-174	415	9	gene	gene	NOUN
aji-174	415	10	transfer	transfer	NOUN
aji-174	415	11	across	across	ADP
aji-174	415	12	divergent	divergent	ADJ
aji-174	415	13	eukaryotes	eukaryote	NOUN
aji-174	415	14	.	.	PUNCT
aji-174	416	1	molecular	molecular	ADJ
aji-174	416	2	biology	biology	NOUN
aji-174	416	3	and	and	CCONJ
aji-174	416	4	evolution	evolution	NOUN
aji-174	416	5	,	,	PUNCT
aji-174	416	6	42(8	42(8	NUM
aji-174	416	7	)	)	PUNCT
aji-174	416	8	,	,	PUNCT
aji-174	416	9	msaf176	msaf176	PROPN
aji-174	416	10	.	.	PUNCT
aji-174	416	11	seyedi	seyedi	PROPN
aji-174	416	12	,	,	PUNCT
aji-174	416	13	d.	d.	PROPN
aji-174	416	14	,	,	PUNCT
aji-174	416	15	espandar	espandar	ADV
aji-174	416	16	,	,	PUNCT
aji-174	416	17	n.	n.	NOUN
aji-174	416	18	,	,	PUNCT
aji-174	416	19	hojatizadeh	hojatizadeh	NOUN
aji-174	416	20	,	,	PUNCT
aji-174	416	21	m.	m.	NOUN
aji-174	416	22	,	,	PUNCT
aji-174	416	23	mohammadi	mohammadi	NOUN
aji-174	416	24	,	,	PUNCT
aji-174	416	25	y.	y.	NOUN
aji-174	416	26	,	,	PUNCT
aji-174	416	27	sadri	sadri	PROPN
aji-174	416	28	,	,	PUNCT
aji-174	416	29	f.	f.	PROPN
aji-174	416	30	,	,	PUNCT
aji-174	416	31	&	&	CCONJ
aji-174	416	32	rezaei	rezaei	PROPN
aji-174	416	33	,	,	PUNCT
aji-174	416	34	z.	z.	PROPN
aji-174	416	35	(	(	PUNCT
aji-174	416	36	2024	2024	NUM
aji-174	416	37	)	)	PUNCT
aji-174	416	38	.	.	PUNCT
aji-174	417	1	noncoding	noncode	VERB
aji-174	417	2	rnas	rna	NOUN
aji-174	417	3	in	in	ADP
aji-174	417	4	rheumatoid	rheumatoid	NOUN
aji-174	417	5	arthritis	arthritis	NOUN
aji-174	417	6	:	:	PUNCT
aji-174	417	7	modulators	modulator	NOUN
aji-174	417	8	of	of	ADP
aji-174	417	9	the	the	DET
aji-174	417	10	nf	nf	NOUN
aji-174	417	11	-	-	PUNCT
aji-174	417	12	κb	κb	NOUN
aji-174	417	13	signaling	signal	VERB
aji-174	417	14	pathway	pathway	NOUN
aji-174	417	15	and	and	CCONJ
aji-174	417	16	therapeutic	therapeutic	ADJ
aji-174	417	17	implications	implication	NOUN
aji-174	417	18	.	.	PUNCT
aji-174	418	1	frontiers	frontier	NOUN
aji-174	418	2	in	in	ADP
aji-174	418	3	immunology	immunology	NOUN
aji-174	418	4	,	,	PUNCT
aji-174	418	5	15	15	NUM
aji-174	418	6	,	,	PUNCT
aji-174	418	7	1486476	1486476	NUM
aji-174	418	8	.	.	PUNCT
aji-174	419	1	shaheen	shaheen	PROPN
aji-174	419	2	,	,	PUNCT
aji-174	419	3	n.	n.	PROPN
aji-174	419	4	,	,	PUNCT
aji-174	419	5	shaheen	shaheen	PROPN
aji-174	419	6	,	,	PUNCT
aji-174	419	7	a.	a.	NOUN
aji-174	419	8	,	,	PUNCT
aji-174	419	9	osama	osama	NOUN
aji-174	419	10	,	,	PUNCT
aji-174	419	11	m.	m.	NOUN
aji-174	419	12	,	,	PUNCT
aji-174	419	13	nashwan	nashwan	PROPN
aji-174	419	14	,	,	PUNCT
aji-174	419	15	a.	a.	PROPN
aji-174	419	16	j.	j.	PROPN
aji-174	419	17	,	,	PUNCT
aji-174	419	18	bharmauria	bharmauria	PROPN
aji-174	419	19	,	,	PUNCT
aji-174	419	20	v.	v.	ADV
aji-174	419	21	,	,	PUNCT
aji-174	419	22	&	&	CCONJ
aji-174	419	23	flouty	flouty	PROPN
aji-174	419	24	,	,	PUNCT
aji-174	419	25	o.	o.	PROPN
aji-174	419	26	(	(	PUNCT
aji-174	419	27	2024	2024	NUM
aji-174	419	28	)	)	PUNCT
aji-174	419	29	.	.	PUNCT
aji-174	420	1	micrornas	microrna	NOUN
aji-174	420	2	regulation	regulation	NOUN
aji-174	420	3	in	in	ADP
aji-174	420	4	parkinson	parkinson	NOUN
aji-174	420	5	’s	’s	PART
aji-174	420	6	disease	disease	NOUN
aji-174	420	7	,	,	PUNCT
aji-174	420	8	and	and	CCONJ
aji-174	420	9	their	their	PRON
aji-174	420	10	potential	potential	ADJ
aji-174	420	11	role	role	NOUN
aji-174	420	12	as	as	ADP
aji-174	420	13	diagnostic	diagnostic	ADJ
aji-174	420	14	and	and	CCONJ
aji-174	420	15	therapeutic	therapeutic	ADJ
aji-174	420	16	targets	target	NOUN
aji-174	420	17	.	.	PUNCT
aji-174	421	1	npj	npj	NOUN
aji-174	421	2	parkinson	parkinson	NOUN
aji-174	421	3	's	's	PART
aji-174	421	4	disease	disease	NOUN
aji-174	421	5	,	,	PUNCT
aji-174	421	6	10(1	10(1	NUM
aji-174	421	7	)	)	PUNCT
aji-174	421	8	,	,	PUNCT
aji-174	421	9	186	186	NUM
aji-174	421	10	.	.	PUNCT
aji-174	422	1	shaikh	shaikh	PROPN
aji-174	422	2	,	,	PUNCT
aji-174	422	3	f.	f.	PROPN
aji-174	422	4	s.	s.	PROPN
aji-174	422	5	,	,	PUNCT
aji-174	422	6	siegel	siegel	PROPN
aji-174	422	7	,	,	PUNCT
aji-174	422	8	r.	r.	PROPN
aji-174	422	9	j.	j.	PROPN
aji-174	422	10	,	,	PUNCT
aji-174	422	11	srivastava	srivastava	PROPN
aji-174	422	12	,	,	PUNCT
aji-174	422	13	a.	a.	PROPN
aji-174	422	14	,	,	PUNCT
aji-174	422	15	fox	fox	PROPN
aji-174	422	16	,	,	PUNCT
aji-174	422	17	d.	d.	PROPN
aji-174	422	18	a.	a.	PROPN
aji-174	422	19	,	,	PUNCT
aji-174	422	20	&	&	CCONJ
aji-174	422	21	ahmed	ahmed	PROPN
aji-174	422	22	,	,	PUNCT
aji-174	422	23	s.	s.	PROPN
aji-174	422	24	(	(	PUNCT
aji-174	422	25	2024	2024	NUM
aji-174	422	26	)	)	PUNCT
aji-174	422	27	.	.	PUNCT
aji-174	423	1	challenges	challenge	NOUN
aji-174	423	2	and	and	CCONJ
aji-174	423	3	promise	promise	NOUN
aji-174	423	4	of	of	ADP
aji-174	423	5	targeting	target	VERB
aji-174	423	6	mirna	mirna	NOUN
aji-174	423	7	in	in	ADP
aji-174	423	8	rheumatic	rheumatic	ADJ
aji-174	423	9	diseases	disease	NOUN
aji-174	423	10	:	:	PUNCT
aji-174	423	11	a	a	DET
aji-174	423	12	computational	computational	ADJ
aji-174	423	13	approach	approach	NOUN
aji-174	423	14	to	to	PART
aji-174	423	15	identify	identify	VERB
aji-174	423	16	mirna	mirna	PROPN
aji-174	423	17	association	association	PROPN
aji-174	423	18	with	with	ADP
aji-174	423	19	cell	cell	NOUN
aji-174	423	20	types	type	NOUN
aji-174	423	21	,	,	PUNCT
aji-174	423	22	cytokines	cytokine	NOUN
aji-174	423	23	,	,	PUNCT
aji-174	423	24	and	and	CCONJ
aji-174	423	25	disease	disease	NOUN
aji-174	423	26	mechanisms	mechanism	NOUN
aji-174	423	27	.	.	PUNCT
aji-174	424	1	frontiers	frontier	NOUN
aji-174	424	2	in	in	ADP
aji-174	424	3	immunology	immunology	NOUN
aji-174	424	4	,	,	PUNCT
aji-174	424	5	14	14	NUM
aji-174	424	6	,	,	PUNCT
aji-174	424	7	1322806	1322806	NUM
aji-174	424	8	.	.	PUNCT
aji-174	425	1	smith	smith	PROPN
aji-174	425	2	,	,	PUNCT
aji-174	425	3	z.	z.	PROPN
aji-174	425	4	d.	d.	PROPN
aji-174	425	5	,	,	PUNCT
aji-174	425	6	hetzel	hetzel	PROPN
aji-174	425	7	,	,	PUNCT
aji-174	425	8	s.	s.	PROPN
aji-174	425	9	,	,	PUNCT
aji-174	425	10	&	&	CCONJ
aji-174	425	11	meissner	meissner	PROPN
aji-174	425	12	,	,	PUNCT
aji-174	425	13	a.	a.	PROPN
aji-174	425	14	(	(	PUNCT
aji-174	425	15	2025	2025	NUM
aji-174	425	16	)	)	PUNCT
aji-174	425	17	.	.	PUNCT
aji-174	426	1	dna	dna	PROPN
aji-174	426	2	methylation	methylation	NOUN
aji-174	426	3	in	in	ADP
aji-174	426	4	mammalian	mammalian	ADJ
aji-174	426	5	development	development	NOUN
aji-174	426	6	and	and	CCONJ
aji-174	426	7	disease	disease	NOUN
aji-174	426	8	.	.	PUNCT
aji-174	427	1	nature	nature	NOUN
aji-174	427	2	reviews	review	VERB
aji-174	427	3	genetics	genetic	NOUN
aji-174	427	4	,	,	PUNCT
aji-174	427	5	26(1	26(1	NUM
aji-174	427	6	)	)	PUNCT
aji-174	427	7	,	,	PUNCT
aji-174	427	8	7–30	7–30	NOUN
aji-174	427	9	.	.	PUNCT
aji-174	428	1	somers	somer	NOUN
aji-174	428	2	,	,	PUNCT
aji-174	428	3	e.	e.	PROPN
aji-174	428	4	c.	c.	PROPN
aji-174	428	5	,	,	PUNCT
aji-174	428	6	goodrich	goodrich	PROPN
aji-174	428	7	,	,	PUNCT
aji-174	428	8	j.	j.	PROPN
aji-174	428	9	m.	m.	PROPN
aji-174	428	10	,	,	PUNCT
aji-174	428	11	wang	wang	PROPN
aji-174	428	12	,	,	PUNCT
aji-174	428	13	l.	l.	PROPN
aji-174	428	14	,	,	PUNCT
aji-174	428	15	harlow	harlow	PROPN
aji-174	428	16	,	,	PUNCT
aji-174	428	17	s.	s.	PROPN
aji-174	428	18	d.	d.	PROPN
aji-174	428	19	,	,	PUNCT
aji-174	428	20	marder	marder	PROPN
aji-174	428	21	,	,	PUNCT
aji-174	428	22	w.	w.	PROPN
aji-174	428	23	,	,	PUNCT
aji-174	428	24	hassett	hassett	PROPN
aji-174	428	25	,	,	PUNCT
aji-174	428	26	a.	a.	PROPN
aji-174	428	27	l.	l.	PROPN
aji-174	428	28	,	,	PUNCT
aji-174	428	29	zick	zick	PROPN
aji-174	428	30	,	,	PUNCT
aji-174	428	31	s.	s.	PROPN
aji-174	428	32	m.	m.	PROPN
aji-174	428	33	,	,	PUNCT
aji-174	428	34	et	et	PROPN
aji-174	428	35	al	al	PROPN
aji-174	428	36	.	.	PUNCT
aji-174	428	37	(	(	PUNCT
aji-174	428	38	2024	2024	NUM
aji-174	428	39	)	)	PUNCT
aji-174	428	40	.	.	PUNCT
aji-174	429	1	associations	association	NOUN
aji-174	429	2	between	between	ADP
aji-174	429	3	cd70	cd70	PROPN
aji-174	429	4	methylation	methylation	NOUN
aji-174	429	5	of	of	ADP
aji-174	429	6	t	t	PROPN
aji-174	429	7	cell	cell	NOUN
aji-174	429	8	dna	dna	NOUN
aji-174	429	9	and	and	CCONJ
aji-174	429	10	age	age	NOUN
aji-174	429	11	in	in	ADP
aji-174	429	12	adults	adult	NOUN
aji-174	429	13	with	with	ADP
aji-174	429	14	systemic	systemic	ADJ
aji-174	429	15	lupus	lupus	NOUN
aji-174	429	16	erythematosus	erythematosus	NOUN
aji-174	429	17	and	and	CCONJ
aji-174	429	18	population	population	NOUN
aji-174	429	19	controls	control	NOUN
aji-174	429	20	:	:	PUNCT
aji-174	429	21	ajibola	ajibola	PROPN
aji-174	429	22	and	and	CCONJ
aji-174	429	23	ayodele	ayodele	PROPN
aji-174	429	24	;	;	PUNCT
aji-174	429	25	asian	asian	PROPN
aji-174	429	26	j.	j.	PROPN
aji-174	429	27	immunol	immunol	PROPN
aji-174	429	28	.	.	PROPN
aji-174	429	29	,	,	PUNCT
aji-174	429	30	vol	vol	NOUN
aji-174	429	31	.	.	PROPN
aji-174	429	32	8	8	NUM
aji-174	429	33	,	,	PUNCT
aji-174	429	34	no	no	INTJ
aji-174	429	35	.	.	NOUN
aji-174	429	36	1	1	NUM
aji-174	429	37	,	,	PUNCT
aji-174	429	38	pp	pp	ADJ
aji-174	429	39	.	.	PUNCT
aji-174	430	1	230	230	NUM
aji-174	430	2	-	-	SYM
aji-174	430	3	241	241	NUM
aji-174	430	4	,	,	PUNCT
aji-174	430	5	2025	2025	NUM
aji-174	430	6	;	;	PUNCT
aji-174	430	7	article	article	NOUN
aji-174	430	8	no.aji.144830	no.aji.144830	NOUN
aji-174	430	9	241	241	NUM
aji-174	430	10	the	the	DET
aji-174	430	11	michigan	michigan	PROPN
aji-174	430	12	lupus	lupus	PROPN
aji-174	430	13	epidemiology	epidemiology	NOUN
aji-174	430	14	&	&	CCONJ
aji-174	430	15	surveillance	surveillance	NOUN
aji-174	430	16	(	(	PUNCT
aji-174	430	17	miles	mile	NOUN
aji-174	430	18	)	)	PUNCT
aji-174	430	19	program	program	NOUN
aji-174	430	20	.	.	PUNCT
aji-174	431	1	journal	journal	PROPN
aji-174	431	2	of	of	ADP
aji-174	431	3	autoimmunity	autoimmunity	NOUN
aji-174	431	4	,	,	PUNCT
aji-174	431	5	142	142	NUM
aji-174	431	6	,	,	PUNCT
aji-174	431	7	103137	103137	NUM
aji-174	431	8	.	.	PUNCT
aji-174	432	1	stroeks	stroek	NOUN
aji-174	432	2	,	,	PUNCT
aji-174	432	3	s.	s.	PROPN
aji-174	432	4	l.	l.	PROPN
aji-174	432	5	,	,	PUNCT
aji-174	432	6	henkens	henkens	PROPN
aji-174	432	7	,	,	PUNCT
aji-174	432	8	m.	m.	NOUN
aji-174	432	9	t.	t.	PROPN
aji-174	432	10	,	,	PUNCT
aji-174	432	11	dominguez	dominguez	PROPN
aji-174	432	12	,	,	PUNCT
aji-174	432	13	f.	f.	PROPN
aji-174	432	14	,	,	PUNCT
aji-174	432	15	merlo	merlo	PROPN
aji-174	432	16	,	,	PUNCT
aji-174	432	17	m.	m.	NOUN
aji-174	432	18	,	,	PUNCT
aji-174	432	19	hellebrekers	hellebreker	NOUN
aji-174	432	20	,	,	PUNCT
aji-174	432	21	d.	d.	PROPN
aji-174	432	22	m.	m.	PROPN
aji-174	432	23	,	,	PUNCT
aji-174	432	24	gonzalezlopez	gonzalezlopez	NOUN
aji-174	432	25	,	,	PUNCT
aji-174	432	26	e.	e.	PROPN
aji-174	432	27	,	,	PUNCT
aji-174	432	28	...	...	PUNCT
aji-174	432	29	&	&	CCONJ
aji-174	432	30	verdonschot	verdonschot	PROPN
aji-174	432	31	,	,	PUNCT
aji-174	432	32	j.	j.	PROPN
aji-174	432	33	a.	a.	PROPN
aji-174	432	34	(	(	PUNCT
aji-174	432	35	2025	2025	NUM
aji-174	432	36	)	)	PUNCT
aji-174	432	37	.	.	PUNCT
aji-174	433	1	genetic	genetic	ADJ
aji-174	433	2	landscape	landscape	NOUN
aji-174	433	3	of	of	ADP
aji-174	433	4	patients	patient	NOUN
aji-174	433	5	with	with	ADP
aji-174	433	6	dilated	dilated	ADJ
aji-174	433	7	cardiomyopathy	cardiomyopathy	ADJ
aji-174	433	8	and	and	CCONJ
aji-174	433	9	a	a	DET
aji-174	433	10	systemic	systemic	ADJ
aji-174	433	11	immunemediated	immunemediate	VERB
aji-174	433	12	disease	disease	NOUN
aji-174	433	13	.	.	PUNCT
aji-174	434	1	heart	heart	NOUN
aji-174	434	2	failure	failure	NOUN
aji-174	434	3	,	,	PUNCT
aji-174	434	4	13(1	13(1	NUM
aji-174	434	5	)	)	PUNCT
aji-174	434	6	,	,	PUNCT
aji-174	434	7	133–145	133–145	NUM
aji-174	434	8	.	.	PUNCT
aji-174	435	1	svendsen	svendsen	PROPN
aji-174	435	2	,	,	PUNCT
aji-174	435	3	a.	a.	PROPN
aji-174	435	4	j.	j.	PROPN
aji-174	435	5	,	,	PUNCT
aji-174	435	6	mengel	mengel	NOUN
aji-174	435	7	-	-	PUNCT
aji-174	435	8	from	from	ADP
aji-174	435	9	,	,	PUNCT
aji-174	435	10	j.	j.	PROPN
aji-174	435	11	,	,	PUNCT
aji-174	435	12	junker	junker	PROPN
aji-174	435	13	,	,	PUNCT
aji-174	435	14	p.	p.	NOUN
aji-174	435	15	,	,	PUNCT
aji-174	435	16	dalgård	dalgård	PROPN
aji-174	435	17	,	,	PUNCT
aji-174	435	18	c.	c.	PROPN
aji-174	435	19	,	,	PUNCT
aji-174	435	20	davey	davey	PROPN
aji-174	435	21	smith	smith	PROPN
aji-174	435	22	,	,	PUNCT
aji-174	435	23	g.	g.	PROPN
aji-174	435	24	,	,	PUNCT
aji-174	435	25	relton	relton	PROPN
aji-174	435	26	,	,	PUNCT
aji-174	435	27	c.	c.	PROPN
aji-174	435	28	l.	l.	PROPN
aji-174	435	29	,	,	PUNCT
aji-174	435	30	...	...	PUNCT
aji-174	435	31	&	&	CCONJ
aji-174	435	32	tan	tan	PROPN
aji-174	435	33	,	,	PUNCT
aji-174	435	34	q.	q.	PROPN
aji-174	435	35	(	(	PUNCT
aji-174	435	36	2025	2025	NUM
aji-174	435	37	)	)	PUNCT
aji-174	435	38	.	.	PUNCT
aji-174	436	1	differential	differential	PROPN
aji-174	436	2	dna	dna	PROPN
aji-174	436	3	methylation	methylation	NOUN
aji-174	436	4	patterns	pattern	NOUN
aji-174	436	5	in	in	ADP
aji-174	436	6	whole	whole	ADJ
aji-174	436	7	blood	blood	NOUN
aji-174	436	8	from	from	ADP
aji-174	436	9	acpa	acpa	NOUN
aji-174	436	10	-	-	ADJ
aji-174	436	11	positive	positive	ADJ
aji-174	436	12	patients	patient	NOUN
aji-174	436	13	with	with	ADP
aji-174	436	14	dmard	dmard	ADJ
aji-174	436	15	naïve	naïve	ADJ
aji-174	436	16	rheumatoid	rheumatoid	NOUN
aji-174	436	17	arthritis	arthritis	NOUN
aji-174	436	18	at	at	ADP
aji-174	436	19	clinical	clinical	ADJ
aji-174	436	20	disease	disease	NOUN
aji-174	436	21	onset	onset	VERB
aji-174	436	22	.	.	PUNCT
aji-174	437	1	frontiers	frontier	NOUN
aji-174	437	2	in	in	ADP
aji-174	437	3	immunology	immunology	NOUN
aji-174	437	4	,	,	PUNCT
aji-174	437	5	16	16	NUM
aji-174	437	6	,	,	PUNCT
aji-174	437	7	1488161	1488161	NUM
aji-174	437	8	.	.	PUNCT
aji-174	438	1	ueberheide	ueberheide	PROPN
aji-174	438	2	,	,	PUNCT
aji-174	438	3	b.	b.	PROPN
aji-174	438	4	m.	m.	PROPN
aji-174	438	5	,	,	PUNCT
aji-174	438	6	mollah	mollah	PROPN
aji-174	438	7	,	,	PUNCT
aji-174	438	8	s.	s.	PROPN
aji-174	438	9	,	,	PUNCT
aji-174	438	10	&	&	CCONJ
aji-174	438	11	garcia	garcia	PROPN
aji-174	438	12	,	,	PUNCT
aji-174	438	13	b.	b.	PROPN
aji-174	438	14	a.	a.	PROPN
aji-174	438	15	(	(	PUNCT
aji-174	438	16	2024	2024	NUM
aji-174	438	17	)	)	PUNCT
aji-174	438	18	.	.	PUNCT
aji-174	439	1	on	on	ADP
aji-174	439	2	the	the	DET
aji-174	439	3	hunt	hunt	NOUN
aji-174	439	4	for	for	ADP
aji-174	439	5	the	the	DET
aji-174	439	6	histone	histone	NOUN
aji-174	439	7	code	code	NOUN
aji-174	439	8	.	.	PUNCT
aji-174	440	1	molecular	molecular	ADJ
aji-174	440	2	&	&	CCONJ
aji-174	440	3	cellular	cellular	ADJ
aji-174	440	4	proteomics	proteomic	NOUN
aji-174	440	5	,	,	PUNCT
aji-174	440	6	23(12	23(12	NUM
aji-174	440	7	)	)	PUNCT
aji-174	440	8	.	.	PUNCT
aji-174	441	1	viel	viel	PROPN
aji-174	441	2	,	,	PUNCT
aji-174	441	3	k.	k.	PROPN
aji-174	441	4	c.	c.	PROPN
aji-174	441	5	m.	m.	PROPN
aji-174	441	6	f.	f.	PROPN
aji-174	441	7	(	(	PUNCT
aji-174	441	8	2024	2024	NUM
aji-174	441	9	)	)	PUNCT
aji-174	441	10	.	.	PUNCT
aji-174	442	1	epstein	epstein	PROPN
aji-174	442	2	-	-	PUNCT
aji-174	442	3	barr	barr	PROPN
aji-174	442	4	nuclear	nuclear	ADJ
aji-174	442	5	antigen	antigen	PROPN
aji-174	442	6	2	2	NUM
aji-174	442	7	(	(	PUNCT
aji-174	442	8	ebna2	ebna2	NOUN
aji-174	442	9	)	)	PUNCT
aji-174	442	10	type	type	NOUN
aji-174	442	11	2	2	NUM
aji-174	442	12	:	:	PUNCT
aji-174	442	13	mechanisms	mechanism	NOUN
aji-174	442	14	and	and	CCONJ
aji-174	442	15	disease	disease	NOUN
aji-174	442	16	implications	implication	NOUN
aji-174	442	17	(	(	PUNCT
aji-174	442	18	doctoral	doctoral	ADJ
aji-174	442	19	dissertation	dissertation	NOUN
aji-174	442	20	,	,	PUNCT
aji-174	442	21	university	university	NOUN
aji-174	442	22	of	of	ADP
aji-174	442	23	cincinnati	cincinnati	PROPN
aji-174	442	24	)	)	PUNCT
aji-174	442	25	.	.	PUNCT
aji-174	443	1	wais	wais	PROPN
aji-174	443	2	,	,	PUNCT
aji-174	443	3	n.	n.	NOUN
aji-174	443	4	,	,	PUNCT
aji-174	443	5	&	&	CCONJ
aji-174	443	6	agrawal	agrawal	PROPN
aji-174	443	7	,	,	PUNCT
aji-174	443	8	d.	d.	PROPN
aji-174	443	9	k.	k.	PROPN
aji-174	443	10	(	(	PUNCT
aji-174	443	11	2024	2024	NUM
aji-174	443	12	)	)	PUNCT
aji-174	443	13	.	.	PUNCT
aji-174	444	1	systemic	systemic	ADJ
aji-174	444	2	lupus	lupus	PROPN
aji-174	444	3	erythematosus	erythematosus	PROPN
aji-174	444	4	:	:	PUNCT
aji-174	444	5	gene	gene	NOUN
aji-174	444	6	polymorphisms	polymorphism	NOUN
aji-174	444	7	,	,	PUNCT
aji-174	444	8	epigenetics	epigenetic	NOUN
aji-174	444	9	,	,	PUNCT
aji-174	444	10	environmental	environmental	ADJ
aji-174	444	11	,	,	PUNCT
aji-174	444	12	hormonal	hormonal	ADJ
aji-174	444	13	and	and	CCONJ
aji-174	444	14	nutritional	nutritional	ADJ
aji-174	444	15	factors	factor	NOUN
aji-174	444	16	in	in	ADP
aji-174	444	17	the	the	DET
aji-174	444	18	consideration	consideration	NOUN
aji-174	444	19	of	of	ADP
aji-174	444	20	personalized	personalized	ADJ
aji-174	444	21	therapy	therapy	NOUN
aji-174	444	22	.	.	PUNCT
aji-174	445	1	archives	archive	NOUN
aji-174	445	2	of	of	ADP
aji-174	445	3	internal	internal	ADJ
aji-174	445	4	medicine	medicine	NOUN
aji-174	445	5	research	research	NOUN
aji-174	445	6	,	,	PUNCT
aji-174	445	7	7(4	7(4	NUM
aji-174	445	8	)	)	PUNCT
aji-174	445	9	,	,	PUNCT
aji-174	445	10	331	331	NUM
aji-174	445	11	.	.	PUNCT
aji-174	446	1	wen	wen	PROPN
aji-174	446	2	,	,	PUNCT
aji-174	446	3	j.	j.	PROPN
aji-174	446	4	,	,	PUNCT
aji-174	446	5	liu	liu	PROPN
aji-174	446	6	,	,	PUNCT
aji-174	446	7	j.	j.	PROPN
aji-174	446	8	,	,	PUNCT
aji-174	446	9	wan	wan	PROPN
aji-174	446	10	,	,	PUNCT
aji-174	446	11	l.	l.	PROPN
aji-174	446	12	,	,	PUNCT
aji-174	446	13	sun	sun	PROPN
aji-174	446	14	,	,	PUNCT
aji-174	446	15	y.	y.	PROPN
aji-174	446	16	,	,	PUNCT
aji-174	446	17	&	&	CCONJ
aji-174	446	18	wang	wang	PROPN
aji-174	446	19	,	,	PUNCT
aji-174	446	20	f.	f.	PROPN
aji-174	446	21	(	(	PUNCT
aji-174	446	22	2025	2025	NUM
aji-174	446	23	)	)	PUNCT
aji-174	446	24	.	.	PUNCT
aji-174	447	1	crosstalk	crosstalk	VERB
aji-174	447	2	between	between	ADP
aji-174	447	3	n6methyladenosine	n6methyladenosine	NOUN
aji-174	447	4	modification	modification	NOUN
aji-174	447	5	and	and	CCONJ
aji-174	447	6	ncrnas	ncrna	NOUN
aji-174	447	7	in	in	ADP
aji-174	447	8	rheumatic	rheumatic	ADJ
aji-174	447	9	diseases	disease	NOUN
aji-174	447	10	:	:	PUNCT
aji-174	447	11	therapeutic	therapeutic	ADJ
aji-174	447	12	and	and	CCONJ
aji-174	447	13	diagnostic	diagnostic	ADJ
aji-174	447	14	implications	implication	NOUN
aji-174	447	15	.	.	PUNCT
aji-174	448	1	inflammation	inflammation	ADJ
aji-174	448	2	research	research	NOUN
aji-174	448	3	,	,	PUNCT
aji-174	448	4	74(1	74(1	NOUN
aji-174	448	5	)	)	PUNCT
aji-174	448	6	,	,	PUNCT
aji-174	448	7	79	79	NUM
aji-174	448	8	.	.	PUNCT
aji-174	449	1	wilkinson	wilkinson	PROPN
aji-174	449	2	,	,	PUNCT
aji-174	449	3	m.	m.	PROPN
aji-174	449	4	j.	j.	PROPN
aji-174	449	5	,	,	PUNCT
aji-174	449	6	&	&	CCONJ
aji-174	449	7	shapiro	shapiro	PROPN
aji-174	449	8	,	,	PUNCT
aji-174	449	9	m.	m.	PROPN
aji-174	449	10	d.	d.	PROPN
aji-174	449	11	(	(	PUNCT
aji-174	449	12	2024	2024	NUM
aji-174	449	13	)	)	PUNCT
aji-174	449	14	.	.	PUNCT
aji-174	450	1	immune	immune	NOUN
aji-174	450	2	-	-	PUNCT
aji-174	450	3	mediated	mediate	VERB
aji-174	450	4	inflammatory	inflammatory	ADJ
aji-174	450	5	diseases	disease	NOUN
aji-174	450	6	,	,	PUNCT
aji-174	450	7	dyslipidemia	dyslipidemia	NOUN
aji-174	450	8	,	,	PUNCT
aji-174	450	9	and	and	CCONJ
aji-174	450	10	cardiovascular	cardiovascular	ADJ
aji-174	450	11	risk	risk	NOUN
aji-174	450	12	:	:	PUNCT
aji-174	450	13	a	a	DET
aji-174	450	14	complex	complex	ADJ
aji-174	450	15	interplay	interplay	NOUN
aji-174	450	16	.	.	PUNCT
aji-174	451	1	arteriosclerosis	arteriosclerosis	NOUN
aji-174	451	2	,	,	PUNCT
aji-174	451	3	thrombosis	thrombosis	NOUN
aji-174	451	4	,	,	PUNCT
aji-174	451	5	and	and	CCONJ
aji-174	451	6	vascular	vascular	ADJ
aji-174	451	7	biology	biology	NOUN
aji-174	451	8	,	,	PUNCT
aji-174	451	9	44(12	44(12	NUM
aji-174	451	10	)	)	PUNCT
aji-174	451	11	,	,	PUNCT
aji-174	451	12	2396–2406	2396–2406	NUM
aji-174	451	13	.	.	PUNCT
aji-174	452	1	xie	xie	PROPN
aji-174	452	2	,	,	PUNCT
aji-174	452	3	j.	j.	PROPN
aji-174	452	4	,	,	PUNCT
aji-174	452	5	che	che	PROPN
aji-174	452	6	,	,	PUNCT
aji-174	452	7	s.	s.	PROPN
aji-174	452	8	,	,	PUNCT
aji-174	452	9	liu	liu	PROPN
aji-174	452	10	,	,	PUNCT
aji-174	452	11	j.	j.	PROPN
aji-174	452	12	,	,	PUNCT
aji-174	452	13	&	&	CCONJ
aji-174	452	14	long	long	ADV
aji-174	452	15	,	,	PUNCT
aji-174	452	16	x.	x.	NOUN
aji-174	452	17	(	(	PUNCT
aji-174	452	18	2025	2025	NUM
aji-174	452	19	)	)	PUNCT
aji-174	452	20	.	.	PUNCT
aji-174	453	1	sirt1	sirt1	NOUN
aji-174	453	2	:	:	PUNCT
aji-174	453	3	potential	potential	ADJ
aji-174	453	4	target	target	NOUN
aji-174	453	5	in	in	ADP
aji-174	453	6	glucocorticoidresistant	glucocorticoidresistant	ADJ
aji-174	453	7	diseases	disease	NOUN
aji-174	453	8	.	.	PUNCT
aji-174	454	1	frontiers	frontier	NOUN
aji-174	454	2	in	in	ADP
aji-174	454	3	immunology	immunology	NOUN
aji-174	454	4	,	,	PUNCT
aji-174	454	5	16	16	NUM
aji-174	454	6	,	,	PUNCT
aji-174	454	7	1514745	1514745	NUM
aji-174	454	8	.	.	PUNCT
aji-174	455	1	xu	xu	INTJ
aji-174	455	2	,	,	PUNCT
aji-174	455	3	x.	x.	PROPN
aji-174	455	4	,	,	PUNCT
aji-174	455	5	zhou	zhou	PROPN
aji-174	455	6	,	,	PUNCT
aji-174	455	7	j.	j.	PROPN
aji-174	455	8	,	,	PUNCT
aji-174	455	9	xie	xie	PROPN
aji-174	455	10	,	,	PUNCT
aji-174	455	11	h.	h.	PROPN
aji-174	455	12	,	,	PUNCT
aji-174	455	13	zhang	zhang	PROPN
aji-174	455	14	,	,	PUNCT
aji-174	455	15	r.	r.	PROPN
aji-174	455	16	,	,	PUNCT
aji-174	455	17	gu	gu	PROPN
aji-174	455	18	,	,	PUNCT
aji-174	455	19	b.	b.	PROPN
aji-174	455	20	,	,	PUNCT
aji-174	455	21	liu	liu	PROPN
aji-174	455	22	,	,	PUNCT
aji-174	455	23	l.	l.	PROPN
aji-174	455	24	,	,	PUNCT
aji-174	455	25	...	...	PUNCT
aji-174	455	26	&	&	CCONJ
aji-174	455	27	chang	chang	PROPN
aji-174	455	28	,	,	PUNCT
aji-174	455	29	x.	x.	PROPN
aji-174	455	30	(	(	PUNCT
aji-174	455	31	2025	2025	NUM
aji-174	455	32	)	)	PUNCT
aji-174	455	33	.	.	PUNCT
aji-174	456	1	immunomodulatory	immunomodulatory	ADJ
aji-174	456	2	mechanisms	mechanism	NOUN
aji-174	456	3	of	of	ADP
aji-174	456	4	the	the	DET
aji-174	456	5	gut	gut	NOUN
aji-174	456	6	microbiota	microbiota	NOUN
aji-174	456	7	and	and	CCONJ
aji-174	456	8	metabolites	metabolite	NOUN
aji-174	456	9	on	on	ADP
aji-174	456	10	regulatory	regulatory	ADJ
aji-174	456	11	t	t	NOUN
aji-174	456	12	cells	cell	NOUN
aji-174	456	13	in	in	ADP
aji-174	456	14	rheumatoid	rheumatoid	NOUN
aji-174	456	15	arthritis	arthritis	NOUN
aji-174	456	16	.	.	PUNCT
aji-174	457	1	frontiers	frontier	NOUN
aji-174	457	2	in	in	ADP
aji-174	457	3	immunology	immunology	NOUN
aji-174	457	4	,	,	PUNCT
aji-174	457	5	16	16	NUM
aji-174	457	6	,	,	PUNCT
aji-174	457	7	1610254	1610254	NUM
aji-174	457	8	.	.	PUNCT
aji-174	458	1	yue	yue	PROPN
aji-174	458	2	,	,	PUNCT
aji-174	458	3	s.	s.	PROPN
aji-174	458	4	,	,	PUNCT
aji-174	458	5	fan	fan	PROPN
aji-174	458	6	,	,	PUNCT
aji-174	458	7	j.	j.	PROPN
aji-174	458	8	,	,	PUNCT
aji-174	458	9	xie	xie	PROPN
aji-174	458	10	,	,	PUNCT
aji-174	458	11	d.	d.	PROPN
aji-174	458	12	,	,	PUNCT
aji-174	458	13	cao	cao	PROPN
aji-174	458	14	,	,	PUNCT
aji-174	458	15	c.	c.	PROPN
aji-174	458	16	,	,	PUNCT
aji-174	458	17	wang	wang	PROPN
aji-174	458	18	,	,	PUNCT
aji-174	458	19	z.	z.	PROPN
aji-174	458	20	,	,	PUNCT
aji-174	458	21	huang	huang	PROPN
aji-174	458	22	,	,	PUNCT
aji-174	458	23	j.	j.	PROPN
aji-174	458	24	,	,	PUNCT
aji-174	458	25	...	...	PUNCT
aji-174	458	26	&	&	CCONJ
aji-174	458	27	liang	liang	PROPN
aji-174	458	28	,	,	PUNCT
aji-174	458	29	c.	c.	PROPN
aji-174	458	30	(	(	PUNCT
aji-174	458	31	2025	2025	NUM
aji-174	458	32	)	)	PUNCT
aji-174	458	33	.	.	PUNCT
aji-174	459	1	unveiling	unveil	VERB
aji-174	459	2	the	the	DET
aji-174	459	3	therapeutic	therapeutic	ADJ
aji-174	459	4	potential	potential	NOUN
aji-174	459	5	:	:	PUNCT
aji-174	459	6	targeting	target	VERB
aji-174	459	7	fibroblast	fibroblast	ADJ
aji-174	459	8	-	-	PUNCT
aji-174	459	9	like	like	ADJ
aji-174	459	10	synoviocytes	synoviocyte	NOUN
aji-174	459	11	in	in	ADP
aji-174	459	12	rheumatoid	rheumatoid	NOUN
aji-174	459	13	arthritis	arthritis	NOUN
aji-174	459	14	.	.	PUNCT
aji-174	460	1	expert	expert	ADJ
aji-174	460	2	reviews	review	NOUN
aji-174	460	3	in	in	ADP
aji-174	460	4	molecular	molecular	ADJ
aji-174	460	5	medicine	medicine	NOUN
aji-174	460	6	,	,	PUNCT
aji-174	460	7	1–24	1–24	PROPN
aji-174	460	8	.	.	PUNCT
aji-174	461	1	zhang	zhang	PROPN
aji-174	461	2	,	,	PUNCT
aji-174	461	3	y.	y.	PROPN
aji-174	461	4	,	,	PUNCT
aji-174	461	5	maskan	maskan	PROPN
aji-174	461	6	bermudez	bermudez	PROPN
aji-174	461	7	,	,	PUNCT
aji-174	461	8	n.	n.	PROPN
aji-174	461	9	,	,	PUNCT
aji-174	461	10	sa	sa	PROPN
aji-174	461	11	,	,	PUNCT
aji-174	461	12	b.	b.	PROPN
aji-174	461	13	,	,	PUNCT
aji-174	461	14	maderal	maderal	ADJ
aji-174	461	15	,	,	PUNCT
aji-174	461	16	a.	a.	PROPN
aji-174	461	17	d.	d.	PROPN
aji-174	461	18	,	,	PUNCT
aji-174	461	19	&	&	CCONJ
aji-174	461	20	jimenez	jimenez	PROPN
aji-174	461	21	,	,	PUNCT
aji-174	461	22	j.	j.	PROPN
aji-174	461	23	j.	j.	PROPN
aji-174	461	24	(	(	PUNCT
aji-174	461	25	2024	2024	NUM
aji-174	461	26	)	)	PUNCT
aji-174	461	27	.	.	PUNCT
aji-174	462	1	epigenetic	epigenetic	ADJ
aji-174	462	2	mechanisms	mechanism	NOUN
aji-174	462	3	driving	drive	VERB
aji-174	462	4	the	the	DET
aji-174	462	5	pathogenesis	pathogenesis	NOUN
aji-174	462	6	of	of	ADP
aji-174	462	7	systemic	systemic	ADJ
aji-174	462	8	lupus	lupus	PROPN
aji-174	462	9	erythematosus	erythematosus	NOUN
aji-174	462	10	,	,	PUNCT
aji-174	462	11	systemic	systemic	ADJ
aji-174	462	12	sclerosis	sclerosis	NOUN
aji-174	462	13	and	and	CCONJ
aji-174	462	14	dermatomyositis	dermatomyositis	PROPN
aji-174	462	15	.	.	PUNCT
aji-174	463	1	experimental	experimental	ADJ
aji-174	463	2	dermatology	dermatology	NOUN
aji-174	463	3	,	,	PUNCT
aji-174	463	4	33(1	33(1	NUM
aji-174	463	5	)	)	PUNCT
aji-174	463	6	,	,	PUNCT
aji-174	463	7	e14986	e14986	NUM
aji-174	463	8	.	.	PUNCT
aji-174	464	1	zhao	zhao	PROPN
aji-174	464	2	,	,	PUNCT
aji-174	464	3	y.	y.	PROPN
aji-174	464	4	,	,	PUNCT
aji-174	464	5	zhang	zhang	PROPN
aji-174	464	6	,	,	PUNCT
aji-174	464	7	q.	q.	PROPN
aji-174	464	8	,	,	PUNCT
aji-174	464	9	zhang	zhang	PROPN
aji-174	464	10	,	,	PUNCT
aji-174	464	11	b.	b.	PROPN
aji-174	464	12	,	,	PUNCT
aji-174	464	13	dai	dai	PROPN
aji-174	464	14	,	,	PUNCT
aji-174	464	15	y.	y.	PROPN
aji-174	464	16	,	,	PUNCT
aji-174	464	17	gao	gao	PROPN
aji-174	464	18	,	,	PUNCT
aji-174	464	19	y.	y.	PROPN
aji-174	464	20	,	,	PUNCT
aji-174	464	21	li	li	PROPN
aji-174	464	22	,	,	PUNCT
aji-174	464	23	c.	c.	PROPN
aji-174	464	24	,	,	PUNCT
aji-174	464	25	...	...	PUNCT
aji-174	464	26	&	&	CCONJ
aji-174	464	27	li	li	PROPN
aji-174	464	28	,	,	PUNCT
aji-174	464	29	c.	c.	PROPN
aji-174	464	30	(	(	PUNCT
aji-174	464	31	2024	2024	NUM
aji-174	464	32	)	)	PUNCT
aji-174	464	33	.	.	PUNCT
aji-174	465	1	epstein	epstein	PROPN
aji-174	465	2	–	–	PUNCT
aji-174	465	3	barr	barr	PROPN
aji-174	465	4	viruses	virus	NOUN
aji-174	465	5	:	:	PUNCT
aji-174	465	6	their	their	PRON
aji-174	465	7	immune	immune	ADJ
aji-174	465	8	evasion	evasion	NOUN
aji-174	465	9	strategies	strategy	NOUN
aji-174	465	10	and	and	CCONJ
aji-174	465	11	implications	implication	NOUN
aji-174	465	12	for	for	ADP
aji-174	465	13	autoimmune	autoimmune	ADJ
aji-174	465	14	diseases	disease	NOUN
aji-174	465	15	.	.	PUNCT
aji-174	466	1	international	international	ADJ
aji-174	466	2	journal	journal	NOUN
aji-174	466	3	of	of	ADP
aji-174	466	4	molecular	molecular	ADJ
aji-174	466	5	sciences	science	NOUN
aji-174	466	6	,	,	PUNCT
aji-174	466	7	25(15	25(15	NUM
aji-174	466	8	)	)	PUNCT
aji-174	466	9	,	,	PUNCT
aji-174	466	10	8160	8160	NUM
aji-174	466	11	.	.	PUNCT
aji-174	467	1	disclaimer	disclaimer	ADJ
aji-174	467	2	/	/	SYM
aji-174	467	3	publisher	publisher	NOUN
aji-174	467	4	’s	’s	PART
aji-174	467	5	note	note	NOUN
aji-174	467	6	:	:	PUNCT
aji-174	467	7	the	the	DET
aji-174	467	8	statements	statement	NOUN
aji-174	467	9	,	,	PUNCT
aji-174	467	10	opinions	opinion	NOUN
aji-174	467	11	and	and	CCONJ
aji-174	467	12	data	datum	NOUN
aji-174	467	13	contained	contain	VERB
aji-174	467	14	in	in	ADP
aji-174	467	15	all	all	DET
aji-174	467	16	publications	publication	NOUN
aji-174	467	17	are	be	AUX
aji-174	467	18	solely	solely	ADV
aji-174	467	19	those	those	PRON
aji-174	467	20	of	of	ADP
aji-174	467	21	the	the	DET
aji-174	467	22	individual	individual	ADJ
aji-174	467	23	author(s	author(s	PROPN
aji-174	467	24	)	)	PUNCT
aji-174	467	25	and	and	CCONJ
aji-174	467	26	contributor(s	contributor(s	NOUN
aji-174	467	27	)	)	PUNCT
aji-174	467	28	and	and	CCONJ
aji-174	467	29	not	not	PART
aji-174	467	30	of	of	ADP
aji-174	467	31	the	the	DET
aji-174	467	32	publisher	publisher	NOUN
aji-174	467	33	and/or	and/or	CCONJ
aji-174	467	34	the	the	DET
aji-174	467	35	editor(s	editor(s	NOUN
aji-174	467	36	)	)	PUNCT
aji-174	467	37	.	.	PUNCT
aji-174	468	1	this	this	DET
aji-174	468	2	publisher	publisher	NOUN
aji-174	468	3	and/or	and/or	CCONJ
aji-174	468	4	the	the	DET
aji-174	468	5	editor(s	editor(s	NOUN
aji-174	468	6	)	)	PUNCT
aji-174	468	7	disclaim	disclaim	VERB
aji-174	468	8	responsibility	responsibility	NOUN
aji-174	468	9	for	for	ADP
aji-174	468	10	any	any	DET
aji-174	468	11	injury	injury	NOUN
aji-174	468	12	to	to	ADP
aji-174	468	13	people	people	NOUN
aji-174	468	14	or	or	CCONJ
aji-174	468	15	property	property	NOUN
aji-174	468	16	resulting	result	VERB
aji-174	468	17	from	from	ADP
aji-174	468	18	any	any	DET
aji-174	468	19	ideas	idea	NOUN
aji-174	468	20	,	,	PUNCT
aji-174	468	21	methods	method	NOUN
aji-174	468	22	,	,	PUNCT
aji-174	468	23	instructions	instruction	NOUN
aji-174	468	24	or	or	CCONJ
aji-174	468	25	products	product	NOUN
aji-174	468	26	referred	refer	VERB
aji-174	468	27	to	to	ADP
aji-174	468	28	in	in	ADP
aji-174	468	29	the	the	DET
aji-174	468	30	content	content	NOUN
aji-174	468	31	.	.	PUNCT
aji-174	469	1	_	_	PUNCT
aji-174	470	1	_	_	PUNCT
aji-174	471	1	_	_	PUNCT
aji-174	472	1	_	_	PUNCT
aji-174	473	1	_	_	PUNCT
aji-174	474	1	_	_	PUNCT
aji-174	475	1	_	_	PUNCT
aji-174	476	1	_	_	PUNCT
aji-174	477	1	_	_	PUNCT
aji-174	478	1	_	_	PUNCT
aji-174	479	1	_	_	PUNCT
aji-174	480	1	_	_	PUNCT
aji-174	481	1	_	_	PUNCT
aji-174	482	1	_	_	PUNCT
aji-174	483	1	_	_	PUNCT
aji-174	484	1	_	_	PUNCT
aji-174	485	1	_	_	PUNCT
aji-174	486	1	_	_	PUNCT
aji-174	487	1	_	_	PUNCT
aji-174	488	1	_	_	PUNCT
aji-174	489	1	_	_	PUNCT
aji-174	490	1	_	_	PUNCT
aji-174	491	1	_	_	PUNCT
aji-174	492	1	_	_	PUNCT
aji-174	493	1	_	_	PUNCT
aji-174	494	1	_	_	PUNCT
aji-174	495	1	_	_	PUNCT
aji-174	496	1	_	_	PUNCT
aji-174	497	1	_	_	PUNCT
aji-174	498	1	_	_	PUNCT
aji-174	499	1	_	_	PUNCT
aji-174	500	1	_	_	PUNCT
aji-174	501	1	_	_	PUNCT
aji-174	502	1	_	_	PUNCT
aji-174	503	1	_	_	PUNCT
aji-174	504	1	_	_	PUNCT
aji-174	505	1	_	_	PUNCT
aji-174	506	1	_	_	PUNCT
aji-174	507	1	_	_	PUNCT
aji-174	508	1	_	_	PUNCT
aji-174	509	1	_	_	PUNCT
aji-174	510	1	_	_	PUNCT
aji-174	511	1	_	_	PUNCT
aji-174	512	1	_	_	PUNCT
aji-174	513	1	_	_	PUNCT
aji-174	514	1	_	_	PUNCT
aji-174	515	1	_	_	PUNCT
aji-174	516	1	_	_	PUNCT
aji-174	517	1	_	_	PUNCT
aji-174	518	1	_	_	PUNCT
aji-174	519	1	_	_	PUNCT
aji-174	520	1	_	_	PUNCT
aji-174	521	1	_	_	PUNCT
aji-174	522	1	_	_	PUNCT
aji-174	523	1	_	_	PUNCT
aji-174	524	1	_	_	PUNCT
aji-174	525	1	_	_	PUNCT
aji-174	526	1	_	_	PUNCT
aji-174	527	1	_	_	PUNCT
aji-174	528	1	_	_	PUNCT
aji-174	529	1	_	_	PUNCT
aji-174	530	1	_	_	PUNCT
aji-174	531	1	_	_	PUNCT
aji-174	532	1	_	_	PUNCT
aji-174	533	1	_	_	PUNCT
aji-174	534	1	_	_	PUNCT
aji-174	535	1	_	_	PUNCT
aji-174	536	1	_	_	PUNCT
aji-174	537	1	_	_	PUNCT
aji-174	538	1	_	_	PUNCT
aji-174	539	1	_	_	PUNCT
aji-174	540	1	_	_	PUNCT
aji-174	541	1	_	_	PUNCT
aji-174	542	1	_	_	PUNCT
aji-174	543	1	_	_	PUNCT
aji-174	544	1	_	_	PUNCT
aji-174	545	1	_	_	PUNCT
aji-174	546	1	_	_	PUNCT
aji-174	547	1	_	_	PUNCT
aji-174	548	1	_	_	PUNCT
aji-174	549	1	_	_	PUNCT
aji-174	550	1	©	©	PRON
aji-174	550	2	copyright	copyright	NOUN
aji-174	550	3	(	(	PUNCT
aji-174	550	4	2025	2025	NUM
aji-174	550	5	):	):	PUNCT
aji-174	550	6	author(s	author(s	NOUN
aji-174	550	7	)	)	PUNCT
aji-174	550	8	.	.	PUNCT
aji-174	551	1	the	the	DET
aji-174	551	2	licensee	licensee	NOUN
aji-174	551	3	is	be	AUX
aji-174	551	4	the	the	DET
aji-174	551	5	journal	journal	PROPN
aji-174	551	6	publisher	publisher	NOUN
aji-174	551	7	.	.	PUNCT
aji-174	552	1	this	this	PRON
aji-174	552	2	is	be	AUX
aji-174	552	3	an	an	DET
aji-174	552	4	open	open	ADJ
aji-174	552	5	access	access	NOUN
aji-174	552	6	article	article	NOUN
aji-174	552	7	distributed	distribute	VERB
aji-174	552	8	under	under	ADP
aji-174	552	9	the	the	DET
aji-174	552	10	terms	term	NOUN
aji-174	552	11	of	of	ADP
aji-174	552	12	the	the	DET
aji-174	552	13	creative	creative	ADJ
aji-174	552	14	commons	common	NOUN
aji-174	552	15	attribution	attribution	NOUN
aji-174	552	16	license	license	NOUN
aji-174	552	17	(	(	PUNCT
aji-174	552	18	http://creativecommons.org/licenses/by/4.0	http://creativecommons.org/licenses/by/4.0	NOUN
aji-174	552	19	)	)	PUNCT
aji-174	552	20	,	,	PUNCT
aji-174	552	21	which	which	PRON
aji-174	552	22	permits	permit	VERB
aji-174	552	23	unrestricted	unrestricted	ADJ
aji-174	552	24	use	use	NOUN
aji-174	552	25	,	,	PUNCT
aji-174	552	26	distribution	distribution	NOUN
aji-174	552	27	,	,	PUNCT
aji-174	552	28	and	and	CCONJ
aji-174	552	29	reproduction	reproduction	NOUN
aji-174	552	30	in	in	ADP
aji-174	552	31	any	any	DET
aji-174	552	32	medium	medium	NOUN
aji-174	552	33	,	,	PUNCT
aji-174	552	34	provided	provide	VERB
aji-174	552	35	the	the	DET
aji-174	552	36	original	original	ADJ
aji-174	552	37	work	work	NOUN
aji-174	552	38	is	be	AUX
aji-174	552	39	properly	properly	ADV
aji-174	552	40	cited	cite	VERB
aji-174	552	41	.	.	PUNCT
aji-174	553	1	peer	peer	NOUN
aji-174	553	2	-	-	PUNCT
aji-174	553	3	review	review	NOUN
aji-174	553	4	history	history	NOUN
aji-174	553	5	:	:	PUNCT
aji-174	553	6	the	the	DET
aji-174	553	7	peer	peer	NOUN
aji-174	553	8	review	review	NOUN
aji-174	553	9	history	history	NOUN
aji-174	553	10	for	for	ADP
aji-174	553	11	this	this	DET
aji-174	553	12	paper	paper	NOUN
aji-174	553	13	can	can	AUX
aji-174	553	14	be	be	AUX
aji-174	553	15	accessed	access	VERB
aji-174	553	16	here	here	ADV
aji-174	553	17	:	:	PUNCT
aji-174	553	18	https://pr.sdiarticle5.com/review-history/144830	https://pr.sdiarticle5.com/review-history/144830	PROPN
aji-174	553	19	https://pr.sdiarticle5.com/review-history/144830	https://pr.sdiarticle5.com/review-history/144830	PUNCT