id	sid	tid	token	lemma	pos
aji-177	1	1	_	_	PUNCT
aji-177	2	1	_	_	PUNCT
aji-177	3	1	_	_	PUNCT
aji-177	4	1	_	_	PUNCT
aji-177	5	1	_	_	PUNCT
aji-177	6	1	_	_	PUNCT
aji-177	7	1	_	_	PUNCT
aji-177	8	1	_	_	PUNCT
aji-177	9	1	_	_	PUNCT
aji-177	10	1	_	_	PUNCT
aji-177	11	1	_	_	PUNCT
aji-177	12	1	_	_	PUNCT
aji-177	13	1	_	_	PUNCT
aji-177	14	1	_	_	PUNCT
aji-177	15	1	_	_	PUNCT
aji-177	16	1	_	_	PUNCT
aji-177	17	1	_	_	PUNCT
aji-177	18	1	_	_	PUNCT
aji-177	19	1	_	_	PUNCT
aji-177	20	1	_	_	PUNCT
aji-177	21	1	_	_	PUNCT
aji-177	22	1	_	_	PUNCT
aji-177	23	1	_	_	PUNCT
aji-177	24	1	_	_	PUNCT
aji-177	25	1	_	_	PUNCT
aji-177	26	1	_	_	PUNCT
aji-177	27	1	_	_	PUNCT
aji-177	28	1	_	_	PUNCT
aji-177	29	1	_	_	PUNCT
aji-177	30	1	_	_	PUNCT
aji-177	31	1	_	_	PUNCT
aji-177	32	1	_	_	PUNCT
aji-177	33	1	_	_	PUNCT
aji-177	34	1	_	_	PUNCT
aji-177	35	1	_	_	PUNCT
aji-177	36	1	_	_	PUNCT
aji-177	37	1	_	_	PUNCT
aji-177	38	1	_	_	PUNCT
aji-177	39	1	_	_	PUNCT
aji-177	40	1	_	_	PUNCT
aji-177	41	1	_	_	PUNCT
aji-177	42	1	_	_	PUNCT
aji-177	43	1	_	_	PUNCT
aji-177	44	1	_	_	PUNCT
aji-177	45	1	_	_	PUNCT
aji-177	46	1	_	_	PUNCT
aji-177	47	1	_	_	PUNCT
aji-177	48	1	_	_	PUNCT
aji-177	49	1	_	_	PUNCT
aji-177	50	1	_	_	PUNCT
aji-177	51	1	_	_	PUNCT
aji-177	52	1	_	_	PUNCT
aji-177	53	1	_	_	PUNCT
aji-177	54	1	_	_	PUNCT
aji-177	55	1	_	_	PUNCT
aji-177	56	1	_	_	PUNCT
aji-177	57	1	_	_	PUNCT
aji-177	58	1	_	_	PUNCT
aji-177	59	1	_	_	PUNCT
aji-177	60	1	_	_	PUNCT
aji-177	61	1	_	_	PUNCT
aji-177	62	1	_	_	PUNCT
aji-177	63	1	_	_	PUNCT
aji-177	64	1	_	_	PUNCT
aji-177	65	1	_	_	PUNCT
aji-177	66	1	_	_	PUNCT
aji-177	67	1	_	_	PUNCT
aji-177	68	1	_	_	PUNCT
aji-177	69	1	_	_	PUNCT
aji-177	70	1	_	_	PUNCT
aji-177	71	1	_	_	PUNCT
aji-177	72	1	_	_	PUNCT
aji-177	73	1	_	_	PUNCT
aji-177	74	1	_	_	PUNCT
aji-177	75	1	_	_	PUNCT
aji-177	76	1	_	_	PUNCT
aji-177	77	1	_	_	PUNCT
aji-177	78	1	_	_	PUNCT
aji-177	79	1	_	_	PUNCT
aji-177	80	1	_	_	PUNCT
aji-177	81	1	_	_	PUNCT
aji-177	82	1	_	_	PUNCT
aji-177	83	1	_	_	PUNCT
aji-177	84	1	_	_	PUNCT
aji-177	85	1	_	_	PUNCT
aji-177	86	1	_	_	PUNCT
aji-177	87	1	_	_	PUNCT
aji-177	88	1	_	_	PUNCT
aji-177	89	1	_	_	PUNCT
aji-177	90	1	_	_	PUNCT
aji-177	91	1	_	_	PUNCT
aji-177	92	1	_	_	PUNCT
aji-177	93	1	_	_	PUNCT
aji-177	94	1	_	_	PUNCT
aji-177	95	1	_	_	PUNCT
aji-177	96	1	_	_	PUNCT
aji-177	97	1	_	_	PUNCT
aji-177	98	1	_	_	PUNCT
aji-177	99	1	_	_	PUNCT
aji-177	100	1	_	_	PUNCT
aji-177	101	1	_	_	PUNCT
aji-177	102	1	*	*	PUNCT
aji-177	102	2	corresponding	correspond	VERB
aji-177	102	3	author	author	NOUN
aji-177	102	4	:	:	PUNCT
aji-177	102	5	e	e	NOUN
aji-177	102	6	-	-	NOUN
aji-177	102	7	mail	mail	NOUN
aji-177	102	8	:	:	PUNCT
aji-177	102	9	arirejay@gmail.com	arirejay@gmail.com	X
aji-177	102	10	;	;	PUNCT
aji-177	102	11	cite	cite	VERB
aji-177	102	12	as	as	ADP
aji-177	102	13	:	:	PUNCT
aji-177	102	14	islam	islam	PROPN
aji-177	102	15	ariremako	ariremako	PROPN
aji-177	102	16	jimoh	jimoh	PROPN
aji-177	102	17	,	,	PUNCT
aji-177	102	18	tobechi	tobechi	PROPN
aji-177	102	19	brendan	brendan	PROPN
aji-177	102	20	nnanna	nnanna	PROPN
aji-177	102	21	,	,	PUNCT
aji-177	102	22	taiwo	taiwo	PROPN
aji-177	102	23	micheal	micheal	PROPN
aji-177	102	24	olumuji	olumuji	PROPN
aji-177	102	25	,	,	PUNCT
aji-177	102	26	paul	paul	PROPN
aji-177	102	27	onyekachi	onyekachi	PROPN
aji-177	102	28	ukegbu	ukegbu	PROPN
aji-177	102	29	,	,	PUNCT
aji-177	102	30	michael	michael	PROPN
aji-177	102	31	sewanu	sewanu	VERB
aji-177	102	32	hungbo	hungbo	PROPN
aji-177	102	33	,	,	PUNCT
aji-177	102	34	and	and	CCONJ
aji-177	102	35	kanime	kanime	PROPN
aji-177	102	36	hussaini	hussaini	PROPN
aji-177	102	37	.	.	PROPN
aji-177	102	38	2025	2025	NUM
aji-177	102	39	.	.	PUNCT
aji-177	103	1	“	"	PUNCT
aji-177	103	2	the	the	DET
aji-177	103	3	gut	gut	PROPN
aji-177	103	4	–	–	PUNCT
aji-177	103	5	net	net	NOUN
aji-177	103	6	–	–	PUNCT
aji-177	103	7	icb	icb	PROPN
aji-177	103	8	axis	axis	NOUN
aji-177	103	9	:	:	PUNCT
aji-177	103	10	microbial	microbial	ADJ
aji-177	103	11	metabolite	metabolite	NOUN
aji-177	103	12	-	-	PUNCT
aji-177	103	13	mediated	mediate	VERB
aji-177	103	14	regulation	regulation	NOUN
aji-177	103	15	of	of	ADP
aji-177	103	16	netosis	netosis	NOUN
aji-177	103	17	and	and	CCONJ
aji-177	103	18	implications	implication	NOUN
aji-177	103	19	for	for	ADP
aji-177	103	20	cancer	cancer	NOUN
aji-177	103	21	immunotherapy	immunotherapy	NOUN
aji-177	103	22	”	"	PUNCT
aji-177	103	23	.	.	PUNCT
aji-177	104	1	asian	asian	ADJ
aji-177	104	2	journal	journal	NOUN
aji-177	104	3	of	of	ADP
aji-177	104	4	immunology	immunology	NOUN
aji-177	104	5	8	8	NUM
aji-177	104	6	(	(	PUNCT
aji-177	104	7	1):257–268	1):257–268	NUM
aji-177	104	8	.	.	PUNCT
aji-177	105	1	https://doi.org/10.9734/aji/2025/v8i1177	https://doi.org/10.9734/aji/2025/v8i1177	PROPN
aji-177	105	2	.	.	PUNCT
aji-177	106	1	asian	asian	PROPN
aji-177	106	2	journal	journal	PROPN
aji-177	106	3	of	of	ADP
aji-177	106	4	immunology	immunology	NOUN
aji-177	106	5	volume	volume	NOUN
aji-177	106	6	8	8	NUM
aji-177	106	7	,	,	PUNCT
aji-177	106	8	issue	issue	NOUN
aji-177	106	9	1	1	NUM
aji-177	106	10	,	,	PUNCT
aji-177	106	11	page	page	NOUN
aji-177	106	12	257	257	NUM
aji-177	106	13	-	-	SYM
aji-177	106	14	268	268	NUM
aji-177	106	15	,	,	PUNCT
aji-177	106	16	2025	2025	NUM
aji-177	106	17	;	;	PUNCT
aji-177	106	18	article	article	NOUN
aji-177	106	19	no.aji.147982	no.aji.147982	VERB
aji-177	106	20	the	the	DET
aji-177	106	21	gut	gut	NOUN
aji-177	106	22	–	–	PUNCT
aji-177	106	23	net	net	NOUN
aji-177	106	24	–	–	PUNCT
aji-177	106	25	icb	icb	PROPN
aji-177	106	26	axis	axis	NOUN
aji-177	106	27	:	:	PUNCT
aji-177	106	28	microbial	microbial	ADJ
aji-177	106	29	metabolite	metabolite	NOUN
aji-177	106	30	-	-	PUNCT
aji-177	106	31	mediated	mediate	VERB
aji-177	106	32	regulation	regulation	NOUN
aji-177	106	33	of	of	ADP
aji-177	106	34	netosis	netosis	NOUN
aji-177	106	35	and	and	CCONJ
aji-177	106	36	implications	implication	NOUN
aji-177	106	37	for	for	ADP
aji-177	106	38	cancer	cancer	NOUN
aji-177	106	39	immunotherapy	immunotherapy	NOUN
aji-177	106	40	islam	islam	PROPN
aji-177	106	41	ariremako	ariremako	PROPN
aji-177	106	42	jimoh	jimoh	PROPN
aji-177	106	43	a	a	PROPN
aji-177	106	44	*	*	PROPN
aji-177	106	45	,	,	PUNCT
aji-177	106	46	tobechi	tobechi	PROPN
aji-177	106	47	brendan	brendan	PROPN
aji-177	106	48	nnanna	nnanna	PROPN
aji-177	106	49	b	b	PROPN
aji-177	106	50	,	,	PUNCT
aji-177	106	51	taiwo	taiwo	PROPN
aji-177	106	52	micheal	micheal	PROPN
aji-177	106	53	olumuji	olumuji	PROPN
aji-177	106	54	c	c	PROPN
aji-177	106	55	,	,	PUNCT
aji-177	106	56	paul	paul	PROPN
aji-177	106	57	onyekachi	onyekachi	VERB
aji-177	106	58	ukegbu	ukegbu	PROPN
aji-177	106	59	d	d	PROPN
aji-177	106	60	,	,	PUNCT
aji-177	106	61	michael	michael	PROPN
aji-177	106	62	sewanu	sewanu	VERB
aji-177	106	63	hungbo	hungbo	PROPN
aji-177	106	64	e	e	PROPN
aji-177	106	65	and	and	CCONJ
aji-177	106	66	kanime	kanime	PROPN
aji-177	106	67	hussaini	hussaini	PROPN
aji-177	106	68	f	f	PROPN
aji-177	106	69	a	a	DET
aji-177	106	70	department	department	NOUN
aji-177	106	71	of	of	ADP
aji-177	106	72	microbiology	microbiology	NOUN
aji-177	106	73	,	,	PUNCT
aji-177	106	74	university	university	NOUN
aji-177	106	75	of	of	ADP
aji-177	106	76	ilorin	ilorin	PROPN
aji-177	106	77	,	,	PUNCT
aji-177	106	78	kwara	kwara	PROPN
aji-177	106	79	state	state	PROPN
aji-177	106	80	,	,	PUNCT
aji-177	106	81	nigeria	nigeria	PROPN
aji-177	106	82	.	.	PUNCT
aji-177	107	1	b	b	X
aji-177	107	2	aston	aston	PROPN
aji-177	107	3	pharmacy	pharmacy	PROPN
aji-177	107	4	school	school	NOUN
aji-177	107	5	,	,	PUNCT
aji-177	107	6	college	college	NOUN
aji-177	107	7	of	of	ADP
aji-177	107	8	life	life	NOUN
aji-177	107	9	and	and	CCONJ
aji-177	107	10	health	health	NOUN
aji-177	107	11	sciences	sciences	PROPN
aji-177	107	12	,	,	PUNCT
aji-177	107	13	aston	aston	PROPN
aji-177	107	14	university	university	PROPN
aji-177	107	15	,	,	PUNCT
aji-177	107	16	birmingham	birmingham	PROPN
aji-177	107	17	b4	b4	PROPN
aji-177	107	18	7et	7et	PROPN
aji-177	107	19	,	,	PUNCT
aji-177	107	20	uk	uk	PROPN
aji-177	107	21	.	.	PROPN
aji-177	107	22	c	c	PROPN
aji-177	107	23	department	department	PROPN
aji-177	107	24	of	of	ADP
aji-177	107	25	agricultural	agricultural	ADJ
aji-177	107	26	extension	extension	NOUN
aji-177	107	27	and	and	CCONJ
aji-177	107	28	communication	communication	NOUN
aji-177	107	29	technology	technology	NOUN
aji-177	107	30	,	,	PUNCT
aji-177	107	31	federal	federal	ADJ
aji-177	107	32	university	university	PROPN
aji-177	107	33	of	of	ADP
aji-177	107	34	technology	technology	PROPN
aji-177	107	35	akure	akure	NOUN
aji-177	107	36	,	,	PUNCT
aji-177	107	37	nigeria	nigeria	PROPN
aji-177	107	38	.	.	PUNCT
aji-177	108	1	d	d	PRON
aji-177	108	2	department	department	NOUN
aji-177	108	3	of	of	ADP
aji-177	108	4	pharmacology	pharmacology	NOUN
aji-177	108	5	and	and	CCONJ
aji-177	108	6	toxicology	toxicology	NOUN
aji-177	108	7	,	,	PUNCT
aji-177	108	8	faculty	faculty	NOUN
aji-177	108	9	of	of	ADP
aji-177	108	10	pharmacy	pharmacy	NOUN
aji-177	108	11	,	,	PUNCT
aji-177	108	12	madonna	madonna	PROPN
aji-177	108	13	university	university	PROPN
aji-177	108	14	,	,	PUNCT
aji-177	108	15	elele	elele	PROPN
aji-177	108	16	campus	campus	PROPN
aji-177	108	17	,	,	PUNCT
aji-177	108	18	elele	elele	PROPN
aji-177	108	19	,	,	PUNCT
aji-177	108	20	rivers	river	NOUN
aji-177	108	21	state	state	PROPN
aji-177	108	22	,	,	PUNCT
aji-177	108	23	nigeria	nigeria	PROPN
aji-177	108	24	.	.	PUNCT
aji-177	109	1	e	e	PROPN
aji-177	109	2	department	department	NOUN
aji-177	109	3	of	of	ADP
aji-177	109	4	animal	animal	NOUN
aji-177	109	5	breeding	breeding	NOUN
aji-177	109	6	and	and	CCONJ
aji-177	109	7	genetics	genetic	NOUN
aji-177	109	8	,	,	PUNCT
aji-177	109	9	federal	federal	ADJ
aji-177	109	10	university	university	PROPN
aji-177	109	11	of	of	ADP
aji-177	109	12	agriculture	agriculture	PROPN
aji-177	109	13	,	,	PUNCT
aji-177	109	14	abeokuta	abeokuta	PROPN
aji-177	109	15	,	,	PUNCT
aji-177	109	16	nigeria	nigeria	PROPN
aji-177	109	17	.	.	PUNCT
aji-177	110	1	f	f	PROPN
aji-177	110	2	department	department	PROPN
aji-177	110	3	of	of	ADP
aji-177	110	4	veterinary	veterinary	ADJ
aji-177	110	5	medicine	medicine	NOUN
aji-177	110	6	,	,	PUNCT
aji-177	110	7	university	university	NOUN
aji-177	110	8	of	of	ADP
aji-177	110	9	maiduguri	maiduguri	PROPN
aji-177	110	10	,	,	PUNCT
aji-177	110	11	nigeria	nigeria	PROPN
aji-177	110	12	.	.	PUNCT
aji-177	111	1	authors	author	NOUN
aji-177	111	2	’	'	PUNCT
aji-177	111	3	contributions	contribution	NOUN
aji-177	111	4	this	this	DET
aji-177	111	5	work	work	NOUN
aji-177	111	6	was	be	AUX
aji-177	111	7	carried	carry	VERB
aji-177	111	8	out	out	ADP
aji-177	111	9	in	in	ADP
aji-177	111	10	collaboration	collaboration	NOUN
aji-177	111	11	among	among	ADP
aji-177	111	12	all	all	DET
aji-177	111	13	authors	author	NOUN
aji-177	111	14	.	.	PUNCT
aji-177	112	1	all	all	DET
aji-177	112	2	authors	author	NOUN
aji-177	112	3	read	read	VERB
aji-177	112	4	and	and	CCONJ
aji-177	112	5	approved	approve	VERB
aji-177	112	6	the	the	DET
aji-177	112	7	final	final	ADJ
aji-177	112	8	manuscript	manuscript	NOUN
aji-177	112	9	.	.	PUNCT
aji-177	113	1	article	article	NOUN
aji-177	113	2	information	information	PROPN
aji-177	113	3	doi	doi	PROPN
aji-177	113	4	:	:	PUNCT
aji-177	113	5	https://doi.org/10.9734/aji/2025/v8i1177	https://doi.org/10.9734/aji/2025/v8i1177	X
aji-177	113	6	open	open	ADJ
aji-177	113	7	peer	peer	NOUN
aji-177	113	8	review	review	NOUN
aji-177	113	9	history	history	NOUN
aji-177	113	10	:	:	PUNCT
aji-177	113	11	this	this	DET
aji-177	113	12	journal	journal	NOUN
aji-177	113	13	follows	follow	VERB
aji-177	113	14	the	the	DET
aji-177	113	15	advanced	advance	VERB
aji-177	113	16	open	open	ADJ
aji-177	113	17	peer	peer	NOUN
aji-177	113	18	review	review	NOUN
aji-177	113	19	policy	policy	NOUN
aji-177	113	20	.	.	PUNCT
aji-177	114	1	identity	identity	NOUN
aji-177	114	2	of	of	ADP
aji-177	114	3	the	the	DET
aji-177	114	4	reviewers	reviewer	NOUN
aji-177	114	5	,	,	PUNCT
aji-177	114	6	editor(s	editor(s	NOUN
aji-177	114	7	)	)	PUNCT
aji-177	114	8	and	and	CCONJ
aji-177	114	9	additional	additional	ADJ
aji-177	114	10	reviewers	reviewer	NOUN
aji-177	114	11	,	,	PUNCT
aji-177	114	12	peer	peer	NOUN
aji-177	114	13	review	review	NOUN
aji-177	114	14	comments	comment	NOUN
aji-177	114	15	,	,	PUNCT
aji-177	114	16	different	different	ADJ
aji-177	114	17	versions	version	NOUN
aji-177	114	18	of	of	ADP
aji-177	114	19	the	the	DET
aji-177	114	20	manuscript	manuscript	NOUN
aji-177	114	21	,	,	PUNCT
aji-177	114	22	comments	comment	NOUN
aji-177	114	23	of	of	ADP
aji-177	114	24	the	the	DET
aji-177	114	25	editors	editor	NOUN
aji-177	114	26	,	,	PUNCT
aji-177	114	27	etc	etc	X
aji-177	114	28	are	be	AUX
aji-177	114	29	available	available	ADJ
aji-177	114	30	here	here	ADV
aji-177	114	31	:	:	PUNCT
aji-177	114	32	https://pr.sdiarticle5.com/review-history/147982	https://pr.sdiarticle5.com/review-history/147982	PROPN
aji-177	114	33	received	receive	VERB
aji-177	114	34	:	:	PUNCT
aji-177	114	35	06/09/2025	06/09/2025	NUM
aji-177	114	36	published	publish	VERB
aji-177	114	37	:	:	PUNCT
aji-177	114	38	20/11/2025	20/11/2025	NUM
aji-177	114	39	review	review	NOUN
aji-177	114	40	article	article	NOUN
aji-177	114	41	https://doi.org/10.9734/aji/2025/v8i1177	https://doi.org/10.9734/aji/2025/v8i1177	PROPN
aji-177	114	42	https://pr.sdiarticle5.com/review-history/147982	https://pr.sdiarticle5.com/review-history/147982	PROPN
aji-177	114	43	jimoh	jimoh	PROPN
aji-177	114	44	et	et	PROPN
aji-177	114	45	al	al	PROPN
aji-177	114	46	.	.	PROPN
aji-177	114	47	;	;	PUNCT
aji-177	114	48	asian	asian	PROPN
aji-177	114	49	j.	j.	PROPN
aji-177	114	50	immunol	immunol	PROPN
aji-177	114	51	.	.	PROPN
aji-177	114	52	,	,	PUNCT
aji-177	114	53	vol	vol	NOUN
aji-177	114	54	.	.	PROPN
aji-177	114	55	8	8	NUM
aji-177	114	56	,	,	PUNCT
aji-177	114	57	no	no	INTJ
aji-177	114	58	.	.	NOUN
aji-177	114	59	1	1	NUM
aji-177	114	60	,	,	PUNCT
aji-177	114	61	pp	pp	ADJ
aji-177	114	62	.	.	PUNCT
aji-177	115	1	257	257	NUM
aji-177	115	2	-	-	SYM
aji-177	115	3	268	268	NUM
aji-177	115	4	,	,	PUNCT
aji-177	115	5	2025	2025	NUM
aji-177	115	6	;	;	PUNCT
aji-177	115	7	article	article	NOUN
aji-177	115	8	no.aji.147982	no.aji.147982	VERB
aji-177	115	9	258	258	NUM
aji-177	115	10	abstract	abstract	ADJ
aji-177	115	11	background	background	NOUN
aji-177	115	12	:	:	PUNCT
aji-177	115	13	immune	immune	ADJ
aji-177	115	14	checkpoint	checkpoint	NOUN
aji-177	115	15	blockade	blockade	NOUN
aji-177	115	16	(	(	PUNCT
aji-177	115	17	icb	icb	PROPN
aji-177	115	18	)	)	PUNCT
aji-177	115	19	has	have	AUX
aji-177	115	20	transformed	transform	VERB
aji-177	115	21	oncology	oncology	NOUN
aji-177	115	22	,	,	PUNCT
aji-177	115	23	but	but	CCONJ
aji-177	115	24	its	its	PRON
aji-177	115	25	efficacy	efficacy	NOUN
aji-177	115	26	is	be	AUX
aji-177	115	27	limited	limit	VERB
aji-177	115	28	by	by	ADP
aji-177	115	29	primary	primary	ADJ
aji-177	115	30	and	and	CCONJ
aji-177	115	31	acquired	acquire	VERB
aji-177	115	32	resistance	resistance	NOUN
aji-177	115	33	.	.	PUNCT
aji-177	116	1	the	the	DET
aji-177	116	2	gut	gut	NOUN
aji-177	116	3	microbiome	microbiome	NOUN
aji-177	116	4	is	be	AUX
aji-177	116	5	a	a	DET
aji-177	116	6	established	establish	VERB
aji-177	116	7	determinant	determinant	NOUN
aji-177	116	8	of	of	ADP
aji-177	116	9	icb	icb	PROPN
aji-177	116	10	response	response	NOUN
aji-177	116	11	,	,	PUNCT
aji-177	116	12	while	while	SCONJ
aji-177	116	13	neutrophil	neutrophil	ADJ
aji-177	116	14	extracellular	extracellular	ADJ
aji-177	116	15	traps	trap	NOUN
aji-177	116	16	(	(	PUNCT
aji-177	116	17	nets	net	NOUN
aji-177	116	18	)	)	PUNCT
aji-177	116	19	have	have	AUX
aji-177	116	20	recently	recently	ADV
aji-177	116	21	emerged	emerge	VERB
aji-177	116	22	as	as	ADP
aji-177	116	23	key	key	ADJ
aji-177	116	24	mediators	mediator	NOUN
aji-177	116	25	of	of	ADP
aji-177	116	26	an	an	DET
aji-177	116	27	immunosuppressive	immunosuppressive	ADJ
aji-177	116	28	tumor	tumor	NOUN
aji-177	116	29	microenvironment	microenvironment	NOUN
aji-177	116	30	(	(	PUNCT
aji-177	116	31	tme	tme	NOUN
aji-177	116	32	)	)	PUNCT
aji-177	116	33	and	and	CCONJ
aji-177	116	34	icb	icb	PROPN
aji-177	116	35	resistance	resistance	NOUN
aji-177	116	36	.	.	PUNCT
aji-177	117	1	the	the	DET
aji-177	117	2	mechanistic	mechanistic	ADJ
aji-177	117	3	link	link	NOUN
aji-177	117	4	between	between	ADP
aji-177	117	5	these	these	DET
aji-177	117	6	two	two	NUM
aji-177	117	7	phenomena	phenomenon	NOUN
aji-177	117	8	remains	remain	VERB
aji-177	117	9	elusive	elusive	ADJ
aji-177	117	10	.	.	PUNCT
aji-177	118	1	we	we	PRON
aji-177	118	2	hypothesize	hypothesize	VERB
aji-177	118	3	that	that	PRON
aji-177	118	4	gut	gut	VERB
aji-177	118	5	microbial	microbial	ADJ
aji-177	118	6	metabolites	metabolite	NOUN
aji-177	118	7	serve	serve	VERB
aji-177	118	8	as	as	ADP
aji-177	118	9	critical	critical	ADJ
aji-177	118	10	systemic	systemic	ADJ
aji-177	118	11	messengers	messenger	NOUN
aji-177	118	12	that	that	PRON
aji-177	118	13	modulate	modulate	VERB
aji-177	118	14	net	net	ADJ
aji-177	118	15	formation	formation	NOUN
aji-177	118	16	(	(	PUNCT
aji-177	118	17	netosis	netosis	NOUN
aji-177	118	18	)	)	PUNCT
aji-177	118	19	,	,	PUNCT
aji-177	118	20	thereby	thereby	ADV
aji-177	118	21	influencing	influence	VERB
aji-177	118	22	icb	icb	PROPN
aji-177	118	23	outcomes	outcome	NOUN
aji-177	118	24	.	.	PUNCT
aji-177	119	1	methods	method	NOUN
aji-177	119	2	&	&	CCONJ
aji-177	119	3	findings	finding	NOUN
aji-177	119	4	:	:	PUNCT
aji-177	119	5	through	through	ADP
aji-177	119	6	a	a	DET
aji-177	119	7	synthesis	synthesis	NOUN
aji-177	119	8	of	of	ADP
aji-177	119	9	recent	recent	ADJ
aji-177	119	10	literature	literature	NOUN
aji-177	119	11	,	,	PUNCT
aji-177	119	12	we	we	PRON
aji-177	119	13	delineate	delineate	VERB
aji-177	119	14	a	a	DET
aji-177	119	15	novel	novel	NOUN
aji-177	119	16	"	"	PUNCT
aji-177	119	17	gut	gut	NOUN
aji-177	119	18	-	-	PUNCT
aji-177	119	19	net	net	NOUN
aji-177	119	20	-	-	PUNCT
aji-177	119	21	icb	icb	PROPN
aji-177	119	22	"	"	PUNCT
aji-177	119	23	axis	axis	NOUN
aji-177	119	24	.	.	PUNCT
aji-177	120	1	we	we	PRON
aji-177	120	2	provide	provide	VERB
aji-177	120	3	evidence	evidence	NOUN
aji-177	120	4	that	that	SCONJ
aji-177	120	5	specific	specific	ADJ
aji-177	120	6	microbiota	microbiota	NOUN
aji-177	120	7	-	-	PUNCT
aji-177	120	8	derived	derive	VERB
aji-177	120	9	metabolites	metabolite	NOUN
aji-177	120	10	directly	directly	ADV
aji-177	120	11	regulate	regulate	VERB
aji-177	120	12	netosis	netosis	PRON
aji-177	120	13	.	.	PUNCT
aji-177	121	1	short	short	ADJ
aji-177	121	2	-	-	PUNCT
aji-177	121	3	chain	chain	NOUN
aji-177	121	4	fatty	fatty	NOUN
aji-177	121	5	acids	acid	NOUN
aji-177	121	6	(	(	PUNCT
aji-177	121	7	scfas	scfas	NOUN
aji-177	121	8	)	)	PUNCT
aji-177	121	9	like	like	ADP
aji-177	121	10	butyrate	butyrate	NOUN
aji-177	121	11	and	and	CCONJ
aji-177	121	12	polyamines	polyamine	NOUN
aji-177	121	13	such	such	ADJ
aji-177	121	14	as	as	ADP
aji-177	121	15	spermidine	spermidine	NOUN
aji-177	121	16	suppress	suppress	VERB
aji-177	121	17	net	net	ADJ
aji-177	121	18	formation	formation	NOUN
aji-177	121	19	by	by	ADP
aji-177	121	20	inhibiting	inhibit	VERB
aji-177	121	21	histone	histone	NOUN
aji-177	121	22	deacetylases	deacetylase	NOUN
aji-177	121	23	(	(	PUNCT
aji-177	121	24	hdacs	hdac	NOUN
aji-177	121	25	)	)	PUNCT
aji-177	121	26	,	,	PUNCT
aji-177	121	27	reactive	reactive	ADJ
aji-177	121	28	oxygen	oxygen	NOUN
aji-177	121	29	species	specie	NOUN
aji-177	121	30	(	(	PUNCT
aji-177	121	31	ros	ros	PROPN
aji-177	121	32	)	)	PUNCT
aji-177	121	33	production	production	NOUN
aji-177	121	34	,	,	PUNCT
aji-177	121	35	and	and	CCONJ
aji-177	121	36	peptidyl	peptidyl	NOUN
aji-177	121	37	arginine	arginine	NOUN
aji-177	121	38	deiminase	deiminase	VERB
aji-177	121	39	4	4	NUM
aji-177	121	40	(	(	PUNCT
aji-177	121	41	pad4	pad4	NOUN
aji-177	121	42	)	)	PUNCT
aji-177	121	43	activity	activity	NOUN
aji-177	121	44	.	.	PUNCT
aji-177	122	1	conversely	conversely	ADV
aji-177	122	2	,	,	PUNCT
aji-177	122	3	certain	certain	ADJ
aji-177	122	4	secondary	secondary	ADJ
aji-177	122	5	bile	bile	NOUN
aji-177	122	6	acids	acid	NOUN
aji-177	122	7	can	can	AUX
aji-177	122	8	promote	promote	VERB
aji-177	122	9	netosis	netosis	PRON
aji-177	122	10	.	.	PUNCT
aji-177	123	1	we	we	PRON
aji-177	123	2	propose	propose	VERB
aji-177	123	3	a	a	DET
aji-177	123	4	model	model	NOUN
aji-177	123	5	wherein	wherein	SCONJ
aji-177	123	6	a	a	DET
aji-177	123	7	favorable	favorable	ADJ
aji-177	123	8	gut	gut	NOUN
aji-177	123	9	microbiome	microbiome	NOUN
aji-177	123	10	generates	generate	VERB
aji-177	123	11	a	a	DET
aji-177	123	12	metabolite	metabolite	NOUN
aji-177	123	13	profile	profile	NOUN
aji-177	123	14	that	that	PRON
aji-177	123	15	systemically	systemically	ADV
aji-177	123	16	suppresses	suppress	VERB
aji-177	123	17	pathological	pathological	ADJ
aji-177	123	18	netosis	netosis	NOUN
aji-177	123	19	,	,	PUNCT
aji-177	123	20	thereby	thereby	ADV
aji-177	123	21	remodeling	remodel	VERB
aji-177	123	22	the	the	DET
aji-177	123	23	tme	tme	NOUN
aji-177	123	24	to	to	PART
aji-177	123	25	enhance	enhance	VERB
aji-177	123	26	cd8	cd8	PROPN
aji-177	123	27	+	+	PROPN
aji-177	123	28	t	t	PROPN
aji-177	123	29	-	-	PUNCT
aji-177	123	30	cell	cell	NOUN
aji-177	123	31	infiltration	infiltration	NOUN
aji-177	123	32	and	and	CCONJ
aji-177	123	33	function	function	NOUN
aji-177	123	34	,	,	PUNCT
aji-177	123	35	creating	create	VERB
aji-177	123	36	a	a	DET
aji-177	123	37	state	state	NOUN
aji-177	123	38	permissive	permissive	ADJ
aji-177	123	39	to	to	ADP
aji-177	123	40	icb	icb	PROPN
aji-177	123	41	.	.	PUNCT
aji-177	124	1	conversely	conversely	ADV
aji-177	124	2	,	,	PUNCT
aji-177	124	3	dysbiosis	dysbiosis	NOUN
aji-177	124	4	fosters	foster	VERB
aji-177	124	5	a	a	DET
aji-177	124	6	pro	pro	ADJ
aji-177	124	7	-	-	ADJ
aji-177	124	8	netotic	netotic	ADJ
aji-177	124	9	environment	environment	NOUN
aji-177	124	10	that	that	PRON
aji-177	124	11	drives	drive	VERB
aji-177	124	12	resistance	resistance	NOUN
aji-177	124	13	.	.	PUNCT
aji-177	125	1	conclusion	conclusion	NOUN
aji-177	125	2	:	:	PUNCT
aji-177	125	3	the	the	DET
aji-177	125	4	modulation	modulation	NOUN
aji-177	125	5	of	of	ADP
aji-177	125	6	netosis	netosis	NOUN
aji-177	125	7	by	by	ADP
aji-177	125	8	gut	gut	NOUN
aji-177	125	9	microbial	microbial	ADJ
aji-177	125	10	metabolites	metabolite	NOUN
aji-177	125	11	represents	represent	VERB
aji-177	125	12	a	a	DET
aji-177	125	13	crucial	crucial	ADJ
aji-177	125	14	mechanism	mechanism	NOUN
aji-177	125	15	underlying	underlie	VERB
aji-177	125	16	the	the	DET
aji-177	125	17	microbiome	microbiome	NOUN
aji-177	125	18	's	's	PART
aji-177	125	19	impact	impact	NOUN
aji-177	125	20	on	on	ADP
aji-177	125	21	cancer	cancer	NOUN
aji-177	125	22	immunotherapy	immunotherapy	NOUN
aji-177	125	23	.	.	PUNCT
aji-177	126	1	this	this	DET
aji-177	126	2	mechanistic	mechanistic	ADJ
aji-177	126	3	insight	insight	NOUN
aji-177	126	4	positions	position	NOUN
aji-177	126	5	the	the	DET
aji-177	126	6	gut	gut	NOUN
aji-177	126	7	microbiome	microbiome	NOUN
aji-177	126	8	and	and	CCONJ
aji-177	126	9	netosis	netosis	NOUN
aji-177	126	10	as	as	ADP
aji-177	126	11	complementary	complementary	ADJ
aji-177	126	12	therapeutic	therapeutic	ADJ
aji-177	126	13	targets	target	NOUN
aji-177	126	14	.	.	PUNCT
aji-177	127	1	strategies	strategy	NOUN
aji-177	127	2	to	to	PART
aji-177	127	3	promote	promote	VERB
aji-177	127	4	a	a	DET
aji-177	127	5	netosis	netosis	NOUN
aji-177	127	6	-	-	PUNCT
aji-177	127	7	suppressive	suppressive	ADJ
aji-177	127	8	metabolite	metabolite	NOUN
aji-177	127	9	profile	profile	NOUN
aji-177	127	10	through	through	ADP
aji-177	127	11	dietary	dietary	ADJ
aji-177	127	12	interventions	intervention	NOUN
aji-177	127	13	,	,	PUNCT
aji-177	127	14	pre	pre	ADJ
aji-177	127	15	/	/	SYM
aji-177	127	16	probiotics	probiotic	NOUN
aji-177	127	17	,	,	PUNCT
aji-177	127	18	or	or	CCONJ
aji-177	127	19	postbiotic	postbiotic	ADJ
aji-177	127	20	supplements	supplement	NOUN
aji-177	127	21	or	or	CCONJ
aji-177	127	22	to	to	PART
aji-177	127	23	directly	directly	ADV
aji-177	127	24	inhibit	inhibit	VERB
aji-177	127	25	netosis	netosis	PROPN
aji-177	127	26	(	(	PUNCT
aji-177	127	27	e.g.	e.g.	ADV
aji-177	127	28	,	,	PUNCT
aji-177	127	29	with	with	ADP
aji-177	127	30	pad4	pad4	NOUN
aji-177	127	31	inhibitors	inhibitor	NOUN
aji-177	127	32	)	)	PUNCT
aji-177	127	33	hold	hold	VERB
aji-177	127	34	significant	significant	ADJ
aji-177	127	35	promise	promise	NOUN
aji-177	127	36	for	for	ADP
aji-177	127	37	overcoming	overcome	VERB
aji-177	127	38	icb	icb	PROPN
aji-177	127	39	resistance	resistance	NOUN
aji-177	127	40	and	and	CCONJ
aji-177	127	41	improving	improve	VERB
aji-177	127	42	patient	patient	ADJ
aji-177	127	43	outcomes	outcome	NOUN
aji-177	127	44	.	.	PUNCT
aji-177	128	1	keywords	keyword	NOUN
aji-177	128	2	:	:	PUNCT
aji-177	128	3	gut	gut	VERB
aji-177	128	4	microbiome	microbiome	NOUN
aji-177	128	5	;	;	PUNCT
aji-177	128	6	microbial	microbial	ADJ
aji-177	128	7	metabolites	metabolite	NOUN
aji-177	128	8	;	;	PUNCT
aji-177	128	9	neutrophil	neutrophil	ADJ
aji-177	128	10	extracellular	extracellular	ADJ
aji-177	128	11	traps	trap	NOUN
aji-177	128	12	(	(	PUNCT
aji-177	128	13	nets	net	NOUN
aji-177	128	14	)	)	PUNCT
aji-177	128	15	;	;	PUNCT
aji-177	128	16	netosis	netosis	ADV
aji-177	128	17	;	;	PUNCT
aji-177	128	18	immune	immune	ADJ
aji-177	128	19	checkpoint	checkpoint	NOUN
aji-177	128	20	blockade	blockade	NOUN
aji-177	128	21	;	;	PUNCT
aji-177	128	22	cancer	cancer	NOUN
aji-177	128	23	immunotherapy	immunotherapy	NOUN
aji-177	128	24	;	;	PUNCT
aji-177	128	25	tumor	tumor	NOUN
aji-177	128	26	microenvironment	microenvironment	NOUN
aji-177	128	27	.	.	PUNCT
aji-177	129	1	1	1	X
aji-177	129	2	.	.	X
aji-177	129	3	introduction	introduction	NOUN
aji-177	129	4	the	the	DET
aji-177	129	5	advent	advent	NOUN
aji-177	129	6	of	of	ADP
aji-177	129	7	immune	immune	ADJ
aji-177	129	8	checkpoint	checkpoint	NOUN
aji-177	129	9	blockade	blockade	NOUN
aji-177	129	10	(	(	PUNCT
aji-177	129	11	icb	icb	PROPN
aji-177	129	12	)	)	PUNCT
aji-177	129	13	,	,	PUNCT
aji-177	129	14	which	which	PRON
aji-177	129	15	targets	target	VERB
aji-177	129	16	regulatory	regulatory	ADJ
aji-177	129	17	pathways	pathway	NOUN
aji-177	129	18	such	such	ADJ
aji-177	129	19	as	as	ADP
aji-177	129	20	pd-1	pd-1	ADP
aji-177	129	21	/	/	SYM
aji-177	129	22	pd	pd	NOUN
aji-177	129	23	-	-	PROPN
aji-177	129	24	l1	l1	PROPN
aji-177	129	25	and	and	CCONJ
aji-177	129	26	ctla-4	ctla-4	NOUN
aji-177	129	27	to	to	PART
aji-177	129	28	reinvigorate	reinvigorate	VERB
aji-177	129	29	antitumor	antitumor	PROPN
aji-177	129	30	immunity	immunity	NOUN
aji-177	129	31	,	,	PUNCT
aji-177	129	32	represents	represent	VERB
aji-177	129	33	a	a	DET
aji-177	129	34	paradigm	paradigm	NOUN
aji-177	129	35	shift	shift	NOUN
aji-177	129	36	in	in	ADP
aji-177	129	37	oncology	oncology	NOUN
aji-177	129	38	(	(	PUNCT
aji-177	129	39	ribas	ribas	PROPN
aji-177	129	40	and	and	CCONJ
aji-177	129	41	wolchok	wolchok	NOUN
aji-177	129	42	,	,	PUNCT
aji-177	129	43	2018	2018	NUM
aji-177	129	44	)	)	PUNCT
aji-177	129	45	.	.	PUNCT
aji-177	130	1	despite	despite	SCONJ
aji-177	130	2	producing	produce	VERB
aji-177	130	3	remarkable	remarkable	ADJ
aji-177	130	4	and	and	CCONJ
aji-177	130	5	durable	durable	ADJ
aji-177	130	6	responses	response	NOUN
aji-177	130	7	in	in	ADP
aji-177	130	8	a	a	DET
aji-177	130	9	subset	subset	NOUN
aji-177	130	10	of	of	ADP
aji-177	130	11	patients	patient	NOUN
aji-177	130	12	,	,	PUNCT
aji-177	130	13	icb	icb	PROPN
aji-177	130	14	therapy	therapy	NOUN
aji-177	130	15	is	be	AUX
aji-177	130	16	hampered	hamper	VERB
aji-177	130	17	by	by	ADP
aji-177	130	18	the	the	DET
aji-177	130	19	fact	fact	NOUN
aji-177	130	20	that	that	SCONJ
aji-177	130	21	a	a	DET
aji-177	130	22	significant	significant	ADJ
aji-177	130	23	majority	majority	NOUN
aji-177	130	24	of	of	ADP
aji-177	130	25	individuals	individual	NOUN
aji-177	130	26	experience	experience	VERB
aji-177	130	27	primary	primary	ADJ
aji-177	130	28	or	or	CCONJ
aji-177	130	29	acquired	acquire	VERB
aji-177	130	30	resistance	resistance	NOUN
aji-177	130	31	(	(	PUNCT
aji-177	130	32	mariniello	mariniello	PROPN
aji-177	130	33	et	et	PROPN
aji-177	130	34	al	al	PROPN
aji-177	130	35	.	.	PROPN
aji-177	130	36	,	,	PUNCT
aji-177	130	37	2025	2025	NUM
aji-177	130	38	)	)	PUNCT
aji-177	130	39	.	.	PUNCT
aji-177	131	1	this	this	DET
aji-177	131	2	stark	stark	ADJ
aji-177	131	3	variability	variability	NOUN
aji-177	131	4	in	in	ADP
aji-177	131	5	treatment	treatment	NOUN
aji-177	131	6	outcomes	outcome	NOUN
aji-177	131	7	has	have	AUX
aji-177	131	8	spurred	spur	VERB
aji-177	131	9	intensive	intensive	ADJ
aji-177	131	10	research	research	NOUN
aji-177	131	11	into	into	ADP
aji-177	131	12	the	the	DET
aji-177	131	13	factors	factor	NOUN
aji-177	131	14	that	that	PRON
aji-177	131	15	govern	govern	VERB
aji-177	131	16	icb	icb	PROPN
aji-177	131	17	efficacy	efficacy	NOUN
aji-177	131	18	,	,	PUNCT
aji-177	131	19	leading	lead	VERB
aji-177	131	20	to	to	ADP
aji-177	131	21	the	the	DET
aji-177	131	22	seminal	seminal	ADJ
aji-177	131	23	discovery	discovery	NOUN
aji-177	131	24	that	that	PRON
aji-177	131	25	the	the	DET
aji-177	131	26	gut	gut	NOUN
aji-177	131	27	microbiome	microbiome	NOUN
aji-177	131	28	is	be	AUX
aji-177	131	29	a	a	DET
aji-177	131	30	critical	critical	ADJ
aji-177	131	31	determinant	determinant	NOUN
aji-177	131	32	of	of	ADP
aji-177	131	33	therapeutic	therapeutic	ADJ
aji-177	131	34	success	success	NOUN
aji-177	131	35	.	.	PUNCT
aji-177	132	1	compelling	compelling	ADJ
aji-177	132	2	evidence	evidence	NOUN
aji-177	132	3	from	from	ADP
aji-177	132	4	both	both	DET
aji-177	132	5	preclinical	preclinical	ADJ
aji-177	132	6	models	model	NOUN
aji-177	132	7	and	and	CCONJ
aji-177	132	8	clinical	clinical	ADJ
aji-177	132	9	studies	study	NOUN
aji-177	132	10	has	have	AUX
aji-177	132	11	established	establish	VERB
aji-177	132	12	a	a	DET
aji-177	132	13	causal	causal	ADJ
aji-177	132	14	relationship	relationship	NOUN
aji-177	132	15	between	between	ADP
aji-177	132	16	the	the	DET
aji-177	132	17	composition	composition	NOUN
aji-177	132	18	of	of	ADP
aji-177	132	19	the	the	DET
aji-177	132	20	gut	gut	NOUN
aji-177	132	21	microbiota	microbiota	NOUN
aji-177	132	22	and	and	CCONJ
aji-177	132	23	response	response	NOUN
aji-177	132	24	to	to	ADP
aji-177	132	25	icb	icb	PROPN
aji-177	132	26	.	.	PUNCT
aji-177	133	1	fecal	fecal	ADJ
aji-177	133	2	microbiota	microbiota	NOUN
aji-177	133	3	transplantation	transplantation	NOUN
aji-177	133	4	(	(	PUNCT
aji-177	133	5	fmt	fmt	NOUN
aji-177	133	6	)	)	PUNCT
aji-177	133	7	from	from	ADP
aji-177	133	8	icb	icb	PROPN
aji-177	133	9	responders	responder	NOUN
aji-177	133	10	can	can	AUX
aji-177	133	11	convert	convert	VERB
aji-177	133	12	non	non	NOUN
aji-177	133	13	-	-	NOUN
aji-177	133	14	responders	responder	NOUN
aji-177	133	15	into	into	ADP
aji-177	133	16	responders	responder	NOUN
aji-177	133	17	,	,	PUNCT
aji-177	133	18	demonstrating	demonstrate	VERB
aji-177	133	19	the	the	DET
aji-177	133	20	microbiome	microbiome	NOUN
aji-177	133	21	's	's	PART
aji-177	133	22	potent	potent	ADJ
aji-177	133	23	role	role	NOUN
aji-177	133	24	in	in	ADP
aji-177	133	25	modulating	modulate	VERB
aji-177	133	26	the	the	DET
aji-177	133	27	anti	anti	ADJ
aji-177	133	28	-	-	ADJ
aji-177	133	29	tumor	tumor	ADJ
aji-177	133	30	immune	immune	ADJ
aji-177	133	31	response	response	NOUN
aji-177	133	32	(	(	PUNCT
aji-177	133	33	routy	routy	PROPN
aji-177	133	34	et	et	PROPN
aji-177	133	35	al	al	PROPN
aji-177	133	36	.	.	PROPN
aji-177	133	37	,	,	PUNCT
aji-177	133	38	2018	2018	NUM
aji-177	133	39	,	,	PUNCT
aji-177	133	40	davar	davar	PROPN
aji-177	133	41	et	et	PROPN
aji-177	133	42	al	al	PROPN
aji-177	133	43	.	.	PROPN
aji-177	133	44	,	,	PUNCT
aji-177	133	45	2021	2021	NUM
aji-177	133	46	)	)	PUNCT
aji-177	133	47	.	.	PUNCT
aji-177	134	1	concurrently	concurrently	ADV
aji-177	134	2	,	,	PUNCT
aji-177	134	3	the	the	DET
aji-177	134	4	role	role	NOUN
aji-177	134	5	of	of	ADP
aji-177	134	6	innate	innate	ADJ
aji-177	134	7	immune	immune	ADJ
aji-177	134	8	players	player	NOUN
aji-177	134	9	in	in	ADP
aji-177	134	10	shaping	shape	VERB
aji-177	134	11	the	the	DET
aji-177	134	12	tumor	tumor	NOUN
aji-177	134	13	microenvironment	microenvironment	NOUN
aji-177	134	14	(	(	PUNCT
aji-177	134	15	tme	tme	NOUN
aji-177	134	16	)	)	PUNCT
aji-177	134	17	has	have	AUX
aji-177	134	18	gained	gain	VERB
aji-177	134	19	prominence	prominence	NOUN
aji-177	134	20	.	.	PUNCT
aji-177	135	1	neutrophils	neutrophil	NOUN
aji-177	135	2	,	,	PUNCT
aji-177	135	3	and	and	CCONJ
aji-177	135	4	specifically	specifically	ADV
aji-177	135	5	their	their	PRON
aji-177	135	6	ability	ability	NOUN
aji-177	135	7	to	to	PART
aji-177	135	8	release	release	VERB
aji-177	135	9	neutrophil	neutrophil	ADJ
aji-177	135	10	extracellular	extracellular	ADJ
aji-177	135	11	traps	trap	NOUN
aji-177	135	12	(	(	PUNCT
aji-177	135	13	nets	net	NOUN
aji-177	135	14	)	)	PUNCT
aji-177	135	15	,	,	PUNCT
aji-177	135	16	have	have	AUX
aji-177	135	17	been	be	AUX
aji-177	135	18	implicated	implicate	VERB
aji-177	135	19	in	in	ADP
aji-177	135	20	cancer	cancer	NOUN
aji-177	135	21	progression	progression	NOUN
aji-177	135	22	and	and	CCONJ
aji-177	135	23	therapy	therapy	NOUN
aji-177	135	24	resistance	resistance	NOUN
aji-177	135	25	.	.	PUNCT
aji-177	136	1	nets	net	NOUN
aji-177	136	2	are	be	AUX
aji-177	136	3	web	web	NOUN
aji-177	136	4	-	-	ADJ
aji-177	136	5	like	like	ADJ
aji-177	136	6	structures	structure	NOUN
aji-177	136	7	composed	compose	VERB
aji-177	136	8	of	of	ADP
aji-177	136	9	decondensed	decondense	VERB
aji-177	136	10	chromatin	chromatin	NOUN
aji-177	136	11	decorated	decorate	VERB
aji-177	136	12	with	with	ADP
aji-177	136	13	histones	histone	NOUN
aji-177	136	14	and	and	CCONJ
aji-177	136	15	cytotoxic	cytotoxic	ADJ
aji-177	136	16	granule	granule	NOUN
aji-177	136	17	proteins	protein	NOUN
aji-177	136	18	that	that	PRON
aji-177	136	19	are	be	AUX
aji-177	136	20	extruded	extrude	VERB
aji-177	136	21	by	by	ADP
aji-177	136	22	neutrophils	neutrophil	NOUN
aji-177	136	23	in	in	ADP
aji-177	136	24	a	a	DET
aji-177	136	25	process	process	NOUN
aji-177	136	26	called	call	VERB
aji-177	136	27	netosis	netosis	NOUN
aji-177	136	28	(	(	PUNCT
aji-177	136	29	liu	liu	PROPN
aji-177	136	30	et	et	PROPN
aji-177	136	31	al	al	PROPN
aji-177	136	32	.	.	PROPN
aji-177	136	33	,	,	PUNCT
aji-177	136	34	2025	2025	NUM
aji-177	136	35	)	)	PUNCT
aji-177	136	36	.	.	PUNCT
aji-177	137	1	while	while	SCONJ
aji-177	137	2	physiologically	physiologically	ADV
aji-177	137	3	a	a	DET
aji-177	137	4	host	host	NOUN
aji-177	137	5	defense	defense	NOUN
aji-177	137	6	mechanism	mechanism	NOUN
aji-177	137	7	,	,	PUNCT
aji-177	137	8	aberrant	aberrant	ADJ
aji-177	137	9	net	net	ADJ
aji-177	137	10	formation	formation	NOUN
aji-177	137	11	in	in	ADP
aji-177	137	12	the	the	DET
aji-177	137	13	tme	tme	NOUN
aji-177	137	14	promotes	promote	VERB
aji-177	137	15	metastasis	metastasis	NOUN
aji-177	137	16	,	,	PUNCT
aji-177	137	17	angiogenesis	angiogenesis	NOUN
aji-177	137	18	,	,	PUNCT
aji-177	137	19	and	and	CCONJ
aji-177	137	20	,	,	PUNCT
aji-177	137	21	crucially	crucially	ADV
aji-177	137	22	,	,	PUNCT
aji-177	137	23	immunosuppression	immunosuppression	NOUN
aji-177	137	24	by	by	ADP
aji-177	137	25	physically	physically	ADV
aji-177	137	26	impeding	impede	VERB
aji-177	137	27	t	t	NOUN
aji-177	137	28	-	-	PUNCT
aji-177	137	29	cell	cell	NOUN
aji-177	137	30	infiltration	infiltration	NOUN
aji-177	137	31	and	and	CCONJ
aji-177	137	32	directly	directly	ADV
aji-177	137	33	suppressing	suppress	VERB
aji-177	137	34	t	t	NOUN
aji-177	137	35	-	-	PUNCT
aji-177	137	36	cell	cell	NOUN
aji-177	137	37	cytotoxic	cytotoxic	ADJ
aji-177	137	38	function	function	NOUN
aji-177	137	39	(	(	PUNCT
aji-177	137	40	ayodele	ayodele	PROPN
aji-177	137	41	,	,	PUNCT
aji-177	137	42	2025	2025	NUM
aji-177	137	43	,	,	PUNCT
aji-177	137	44	teijeira	teijeira	PROPN
aji-177	137	45	et	et	PROPN
aji-177	137	46	al	al	PROPN
aji-177	137	47	.	.	PROPN
aji-177	137	48	,	,	PUNCT
aji-177	137	49	2020	2020	NUM
aji-177	137	50	)	)	PUNCT
aji-177	137	51	.	.	PUNCT
aji-177	138	1	recent	recent	ADJ
aji-177	138	2	work	work	NOUN
aji-177	138	3	has	have	AUX
aji-177	138	4	directly	directly	ADV
aji-177	138	5	correlated	correlate	VERB
aji-177	138	6	elevated	elevated	ADJ
aji-177	138	7	levels	level	NOUN
aji-177	138	8	of	of	ADP
aji-177	138	9	nets	net	NOUN
aji-177	138	10	with	with	ADP
aji-177	138	11	resistance	resistance	NOUN
aji-177	138	12	to	to	ADP
aji-177	138	13	icb	icb	PROPN
aji-177	138	14	in	in	ADP
aji-177	138	15	both	both	DET
aji-177	138	16	murine	murine	ADJ
aji-177	138	17	models	model	NOUN
aji-177	138	18	and	and	CCONJ
aji-177	138	19	cancer	cancer	NOUN
aji-177	138	20	patients	patient	NOUN
aji-177	138	21	(	(	PUNCT
aji-177	138	22	yang	yang	PROPN
aji-177	138	23	et	et	PROPN
aji-177	138	24	al	al	PROPN
aji-177	138	25	.	.	PROPN
aji-177	138	26	,	,	PUNCT
aji-177	138	27	2020	2020	NUM
aji-177	138	28	)	)	PUNCT
aji-177	138	29	.	.	PUNCT
aji-177	139	1	a	a	DET
aji-177	139	2	crucial	crucial	ADJ
aji-177	139	3	,	,	PUNCT
aji-177	139	4	yet	yet	CCONJ
aji-177	139	5	under	under	ADV
aji-177	139	6	-	-	PUNCT
aji-177	139	7	explored	explore	VERB
aji-177	139	8	,	,	PUNCT
aji-177	139	9	link	link	NOUN
aji-177	139	10	connecting	connect	VERB
aji-177	139	11	these	these	DET
aji-177	139	12	two	two	NUM
aji-177	139	13	fields	field	NOUN
aji-177	139	14	is	be	AUX
aji-177	139	15	the	the	DET
aji-177	139	16	functional	functional	ADJ
aji-177	139	17	output	output	NOUN
aji-177	139	18	of	of	ADP
aji-177	139	19	the	the	DET
aji-177	139	20	gut	gut	NOUN
aji-177	139	21	microbiome	microbiome	NOUN
aji-177	139	22	:	:	PUNCT
aji-177	139	23	its	its	PRON
aji-177	139	24	dynamic	dynamic	ADJ
aji-177	139	25	metabolome	metabolome	NOUN
aji-177	139	26	.	.	PUNCT
aji-177	140	1	gut	gut	NOUN
aji-177	140	2	bacteria	bacteria	NOUN
aji-177	140	3	metabolize	metabolize	VERB
aji-177	140	4	dietary	dietary	ADJ
aji-177	140	5	and	and	CCONJ
aji-177	140	6	host	host	NOUN
aji-177	140	7	-	-	PUNCT
aji-177	140	8	derived	derive	VERB
aji-177	140	9	substrates	substrate	NOUN
aji-177	140	10	into	into	ADP
aji-177	140	11	a	a	DET
aji-177	140	12	vast	vast	ADJ
aji-177	140	13	array	array	NOUN
aji-177	140	14	of	of	ADP
aji-177	140	15	small	small	ADJ
aji-177	140	16	molecules	molecule	NOUN
aji-177	140	17	,	,	PUNCT
aji-177	140	18	including	include	VERB
aji-177	140	19	short	short	ADJ
aji-177	140	20	-	-	PUNCT
aji-177	140	21	chain	chain	NOUN
aji-177	140	22	fatty	fatty	NOUN
aji-177	140	23	acids	acid	NOUN
aji-177	140	24	(	(	PUNCT
aji-177	140	25	scfas	scfas	NOUN
aji-177	140	26	)	)	PUNCT
aji-177	140	27	,	,	PUNCT
aji-177	140	28	secondary	secondary	ADJ
aji-177	140	29	bile	bile	NOUN
aji-177	140	30	acids	acid	NOUN
aji-177	140	31	,	,	PUNCT
aji-177	140	32	polyamines	polyamine	NOUN
aji-177	140	33	,	,	PUNCT
aji-177	140	34	and	and	CCONJ
aji-177	140	35	tryptophan	tryptophan	NOUN
aji-177	140	36	metabolites	metabolite	NOUN
aji-177	140	37	that	that	PRON
aji-177	140	38	can	can	AUX
aji-177	140	39	enter	enter	VERB
aji-177	140	40	systemic	systemic	ADJ
aji-177	140	41	jimoh	jimoh	PROPN
aji-177	140	42	et	et	PROPN
aji-177	140	43	al	al	PROPN
aji-177	140	44	.	.	PROPN
aji-177	140	45	;	;	PUNCT
aji-177	140	46	asian	asian	PROPN
aji-177	140	47	j.	j.	PROPN
aji-177	140	48	immunol	immunol	PROPN
aji-177	140	49	.	.	PROPN
aji-177	140	50	,	,	PUNCT
aji-177	140	51	vol	vol	NOUN
aji-177	140	52	.	.	PROPN
aji-177	140	53	8	8	NUM
aji-177	140	54	,	,	PUNCT
aji-177	140	55	no	no	INTJ
aji-177	140	56	.	.	NOUN
aji-177	140	57	1	1	NUM
aji-177	140	58	,	,	PUNCT
aji-177	140	59	pp	pp	ADJ
aji-177	140	60	.	.	PUNCT
aji-177	141	1	257	257	NUM
aji-177	141	2	-	-	SYM
aji-177	141	3	268	268	NUM
aji-177	141	4	,	,	PUNCT
aji-177	141	5	2025	2025	NUM
aji-177	141	6	;	;	PUNCT
aji-177	141	7	article	article	NOUN
aji-177	141	8	no.aji.147982	no.aji.147982	VERB
aji-177	141	9	259	259	NUM
aji-177	141	10	fig	fig	NOUN
aji-177	141	11	.	.	PUNCT
aji-177	142	1	1	1	X
aji-177	142	2	.	.	X
aji-177	142	3	the	the	DET
aji-177	142	4	human	human	ADJ
aji-177	142	5	gut	gut	NOUN
aji-177	142	6	(	(	PUNCT
aji-177	142	7	zhang	zhang	X
aji-177	142	8	et	et	PROPN
aji-177	142	9	al	al	PROPN
aji-177	142	10	.	.	PROPN
aji-177	142	11	,	,	PUNCT
aji-177	142	12	2025	2025	NUM
aji-177	142	13	)	)	PUNCT
aji-177	142	14	circulation	circulation	NOUN
aji-177	142	15	and	and	CCONJ
aji-177	142	16	directly	directly	ADV
aji-177	142	17	influence	influence	VERB
aji-177	142	18	the	the	DET
aji-177	142	19	function	function	NOUN
aji-177	142	20	of	of	ADP
aji-177	142	21	immune	immune	ADJ
aji-177	142	22	cells	cell	NOUN
aji-177	142	23	,	,	PUNCT
aji-177	142	24	both	both	CCONJ
aji-177	142	25	within	within	ADP
aji-177	142	26	and	and	CCONJ
aji-177	142	27	outside	outside	ADP
aji-177	142	28	the	the	DET
aji-177	142	29	gut	gut	NOUN
aji-177	142	30	(	(	PUNCT
aji-177	142	31	kaltenmeier	kaltenmeier	X
aji-177	142	32	et	et	PROPN
aji-177	142	33	al	al	PROPN
aji-177	142	34	.	.	PROPN
aji-177	142	35	,	,	PUNCT
aji-177	142	36	2021	2021	NUM
aji-177	142	37	,	,	PUNCT
aji-177	142	38	parada	parada	PROPN
aji-177	142	39	venegas	venegas	PROPN
aji-177	142	40	et	et	PROPN
aji-177	142	41	al	al	PROPN
aji-177	142	42	.	.	PROPN
aji-177	142	43	,	,	PUNCT
aji-177	142	44	2019	2019	NUM
aji-177	142	45	,	,	PUNCT
aji-177	142	46	ajibola	ajibola	PROPN
aji-177	142	47	and	and	CCONJ
aji-177	142	48	ayodele	ayodele	PROPN
aji-177	142	49	,	,	PUNCT
aji-177	142	50	2025	2025	NUM
aji-177	142	51	,	,	PUNCT
aji-177	142	52	jia	jia	PROPN
aji-177	142	53	et	et	PROPN
aji-177	142	54	al	al	PROPN
aji-177	142	55	.	.	PROPN
aji-177	142	56	,	,	PUNCT
aji-177	142	57	‘	'	PUNCT
aji-177	142	58	)	)	PUNCT
aji-177	142	59	.	.	PUNCT
aji-177	143	1	we	we	PRON
aji-177	143	2	hypothesize	hypothesize	VERB
aji-177	143	3	that	that	SCONJ
aji-177	143	4	these	these	DET
aji-177	143	5	microbial	microbial	ADJ
aji-177	143	6	metabolites	metabolite	NOUN
aji-177	143	7	serve	serve	VERB
aji-177	143	8	as	as	ADP
aji-177	143	9	systemic	systemic	ADJ
aji-177	143	10	rheostats	rheostat	NOUN
aji-177	143	11	for	for	ADP
aji-177	143	12	neutrophil	neutrophil	ADJ
aji-177	143	13	activity	activity	NOUN
aji-177	143	14	and	and	CCONJ
aji-177	143	15	netosis	netosis	NOUN
aji-177	143	16	.	.	PUNCT
aji-177	144	1	this	this	DET
aji-177	144	2	review	review	NOUN
aji-177	144	3	aims	aim	VERB
aji-177	144	4	to	to	PART
aji-177	144	5	synthesize	synthesize	VERB
aji-177	144	6	emerging	emerge	VERB
aji-177	144	7	evidence	evidence	NOUN
aji-177	144	8	and	and	CCONJ
aji-177	144	9	provide	provide	VERB
aji-177	144	10	a	a	DET
aji-177	144	11	comprehensive	comprehensive	ADJ
aji-177	144	12	mechanistic	mechanistic	ADJ
aji-177	144	13	framework	framework	NOUN
aji-177	144	14	for	for	ADP
aji-177	144	15	the	the	DET
aji-177	144	16	"	"	PUNCT
aji-177	144	17	gut	gut	NOUN
aji-177	144	18	-	-	PUNCT
aji-177	144	19	net	net	NOUN
aji-177	144	20	-	-	PUNCT
aji-177	144	21	icb	icb	PROPN
aji-177	144	22	"	"	PUNCT
aji-177	144	23	axis	axis	NOUN
aji-177	144	24	.	.	PUNCT
aji-177	145	1	we	we	PRON
aji-177	145	2	will	will	AUX
aji-177	145	3	explore	explore	VERB
aji-177	145	4	how	how	SCONJ
aji-177	145	5	specific	specific	ADJ
aji-177	145	6	gut	gut	NOUN
aji-177	145	7	microbial	microbial	ADJ
aji-177	145	8	metabolites	metabolite	NOUN
aji-177	145	9	directly	directly	ADV
aji-177	145	10	and	and	CCONJ
aji-177	145	11	indirectly	indirectly	ADV
aji-177	145	12	modulate	modulate	VERB
aji-177	145	13	the	the	DET
aji-177	145	14	molecular	molecular	ADJ
aji-177	145	15	pathways	pathway	NOUN
aji-177	145	16	of	of	ADP
aji-177	145	17	netosis	netosis	NOUN
aji-177	145	18	.	.	PUNCT
aji-177	146	1	furthermore	furthermore	ADV
aji-177	146	2	,	,	PUNCT
aji-177	146	3	we	we	PRON
aji-177	146	4	will	will	AUX
aji-177	146	5	propose	propose	VERB
aji-177	146	6	an	an	DET
aji-177	146	7	integrated	integrated	ADJ
aji-177	146	8	model	model	NOUN
aji-177	146	9	wherein	wherein	SCONJ
aji-177	146	10	a	a	DET
aji-177	146	11	favorable	favorable	ADJ
aji-177	146	12	microbiome	microbiome	NOUN
aji-177	146	13	,	,	PUNCT
aji-177	146	14	through	through	ADP
aji-177	146	15	its	its	PRON
aji-177	146	16	metabolite	metabolite	NOUN
aji-177	146	17	profile	profile	NOUN
aji-177	146	18	,	,	PUNCT
aji-177	146	19	suppresses	suppress	VERB
aji-177	146	20	pathological	pathological	ADJ
aji-177	146	21	net	net	ADJ
aji-177	146	22	formation	formation	NOUN
aji-177	146	23	,	,	PUNCT
aji-177	146	24	thereby	thereby	ADV
aji-177	146	25	remodeling	remodel	VERB
aji-177	146	26	the	the	DET
aji-177	146	27	tme	tme	NOUN
aji-177	146	28	to	to	PART
aji-177	146	29	be	be	AUX
aji-177	146	30	more	more	ADV
aji-177	146	31	permissive	permissive	ADJ
aji-177	146	32	to	to	ADP
aji-177	146	33	t	t	PROPN
aji-177	146	34	-	-	PUNCT
aji-177	146	35	cellmediated	cellmediate	VERB
aji-177	146	36	killing	killing	NOUN
aji-177	146	37	and	and	CCONJ
aji-177	146	38	enhancing	enhance	VERB
aji-177	146	39	icb	icb	PROPN
aji-177	146	40	efficacy	efficacy	NOUN
aji-177	146	41	.	.	PUNCT
aji-177	147	1	elucidating	elucidate	VERB
aji-177	147	2	this	this	DET
aji-177	147	3	axis	axis	NOUN
aji-177	147	4	not	not	PART
aji-177	147	5	only	only	ADV
aji-177	147	6	deepens	deepen	VERB
aji-177	147	7	our	our	PRON
aji-177	147	8	fundamental	fundamental	ADJ
aji-177	147	9	understanding	understanding	NOUN
aji-177	147	10	of	of	ADP
aji-177	147	11	immunotherapy	immunotherapy	NOUN
aji-177	147	12	resistance	resistance	NOUN
aji-177	147	13	but	but	CCONJ
aji-177	147	14	also	also	ADV
aji-177	147	15	unveils	unveil	VERB
aji-177	147	16	novel	novel	ADJ
aji-177	147	17	therapeutic	therapeutic	ADJ
aji-177	147	18	strategies	strategy	NOUN
aji-177	147	19	to	to	PART
aji-177	147	20	modulate	modulate	VERB
aji-177	147	21	the	the	DET
aji-177	147	22	immune	immune	ADJ
aji-177	147	23	system	system	NOUN
aji-177	147	24	for	for	ADP
aji-177	147	25	improved	improved	ADJ
aji-177	147	26	cancer	cancer	NOUN
aji-177	147	27	treatment	treatment	NOUN
aji-177	147	28	.	.	PUNCT
aji-177	148	1	2	2	X
aji-177	148	2	.	.	X
aji-177	148	3	gut	gut	VERB
aji-177	148	4	microbial	microbial	ADJ
aji-177	148	5	metabolites	metabolite	NOUN
aji-177	148	6	:	:	PUNCT
aji-177	148	7	key	key	ADJ
aji-177	148	8	mediators	mediator	NOUN
aji-177	148	9	of	of	ADP
aji-177	148	10	host	host	NOUN
aji-177	148	11	immunity	immunity	NOUN
aji-177	148	12	the	the	DET
aji-177	148	13	gut	gut	NOUN
aji-177	148	14	microbiome	microbiome	NOUN
aji-177	148	15	exerts	exert	VERB
aji-177	148	16	a	a	DET
aji-177	148	17	profound	profound	ADJ
aji-177	148	18	influence	influence	NOUN
aji-177	148	19	on	on	ADP
aji-177	148	20	host	host	NOUN
aji-177	148	21	physiology	physiology	NOUN
aji-177	148	22	not	not	PART
aji-177	148	23	merely	merely	ADV
aji-177	148	24	through	through	ADP
aji-177	148	25	its	its	PRON
aji-177	148	26	presence	presence	NOUN
aji-177	148	27	but	but	CCONJ
aji-177	148	28	through	through	ADP
aji-177	148	29	its	its	PRON
aji-177	148	30	immense	immense	ADJ
aji-177	148	31	metabolic	metabolic	NOUN
aji-177	148	32	activity	activity	NOUN
aji-177	148	33	.	.	PUNCT
aji-177	149	1	it	it	PRON
aji-177	149	2	functions	function	VERB
aji-177	149	3	as	as	ADP
aji-177	149	4	a	a	DET
aji-177	149	5	virtual	virtual	ADJ
aji-177	149	6	endocrine	endocrine	NOUN
aji-177	149	7	organ	organ	NOUN
aji-177	149	8	,	,	PUNCT
aji-177	149	9	converting	convert	VERB
aji-177	149	10	dietary	dietary	ADJ
aji-177	149	11	components	component	NOUN
aji-177	149	12	and	and	CCONJ
aji-177	149	13	host	host	NOUN
aji-177	149	14	-	-	PUNCT
aji-177	149	15	derived	derive	VERB
aji-177	149	16	substances	substance	NOUN
aji-177	149	17	into	into	ADP
aji-177	149	18	a	a	DET
aji-177	149	19	diverse	diverse	ADJ
aji-177	149	20	array	array	NOUN
aji-177	149	21	of	of	ADP
aji-177	149	22	small	small	ADJ
aji-177	149	23	molecules	molecule	NOUN
aji-177	149	24	that	that	PRON
aji-177	149	25	serve	serve	VERB
aji-177	149	26	as	as	ADP
aji-177	149	27	key	key	ADJ
aji-177	149	28	communicators	communicator	NOUN
aji-177	149	29	with	with	ADP
aji-177	149	30	the	the	DET
aji-177	149	31	host	host	NOUN
aji-177	149	32	's	's	PART
aji-177	149	33	immune	immune	ADJ
aji-177	149	34	system	system	NOUN
aji-177	149	35	(	(	PUNCT
aji-177	149	36	ayodele	ayodele	PROPN
aji-177	149	37	,	,	PUNCT
aji-177	149	38	2025	2025	NUM
aji-177	149	39	)	)	PUNCT
aji-177	149	40	.	.	PUNCT
aji-177	150	1	these	these	DET
aji-177	150	2	metabolites	metabolite	NOUN
aji-177	150	3	can	can	AUX
aji-177	150	4	mediate	mediate	VERB
aji-177	150	5	their	their	PRON
aji-177	150	6	effects	effect	NOUN
aji-177	150	7	locally	locally	ADV
aji-177	150	8	within	within	ADP
aji-177	150	9	the	the	DET
aji-177	150	10	gastrointestinal	gastrointestinal	ADJ
aji-177	150	11	tract	tract	NOUN
aji-177	150	12	or	or	CCONJ
aji-177	150	13	,	,	PUNCT
aji-177	150	14	upon	upon	SCONJ
aji-177	150	15	absorption	absorption	NOUN
aji-177	150	16	into	into	ADP
aji-177	150	17	the	the	DET
aji-177	150	18	portal	portal	ADJ
aji-177	150	19	circulation	circulation	NOUN
aji-177	150	20	,	,	PUNCT
aji-177	150	21	systemically	systemically	ADV
aji-177	150	22	throughout	throughout	ADP
aji-177	150	23	the	the	DET
aji-177	150	24	body	body	NOUN
aji-177	150	25	,	,	PUNCT
aji-177	150	26	thereby	thereby	ADV
aji-177	150	27	influencing	influence	VERB
aji-177	150	28	immune	immune	ADJ
aji-177	150	29	responses	response	NOUN
aji-177	150	30	in	in	ADP
aji-177	150	31	distant	distant	ADJ
aji-177	150	32	sites	site	NOUN
aji-177	150	33	,	,	PUNCT
aji-177	150	34	including	include	VERB
aji-177	150	35	the	the	DET
aji-177	150	36	tumor	tumor	NOUN
aji-177	150	37	microenvironment	microenvironment	NOUN
aji-177	150	38	(	(	PUNCT
aji-177	150	39	tme	tme	PROPN
aji-177	150	40	)	)	PUNCT
aji-177	150	41	(	(	PUNCT
aji-177	150	42	jia	jia	PROPN
aji-177	150	43	et	et	PROPN
aji-177	150	44	al	al	PROPN
aji-177	150	45	.	.	PROPN
aji-177	150	46	,	,	PUNCT
aji-177	150	47	2018	2018	NUM
aji-177	150	48	)	)	PUNCT
aji-177	150	49	.	.	PUNCT
aji-177	151	1	jimoh	jimoh	PROPN
aji-177	151	2	et	et	PROPN
aji-177	151	3	al	al	PROPN
aji-177	151	4	.	.	PROPN
aji-177	151	5	;	;	PUNCT
aji-177	151	6	asian	asian	PROPN
aji-177	151	7	j.	j.	PROPN
aji-177	151	8	immunol	immunol	PROPN
aji-177	151	9	.	.	PROPN
aji-177	151	10	,	,	PUNCT
aji-177	151	11	vol	vol	NOUN
aji-177	151	12	.	.	PROPN
aji-177	151	13	8	8	NUM
aji-177	151	14	,	,	PUNCT
aji-177	151	15	no	no	INTJ
aji-177	151	16	.	.	NOUN
aji-177	151	17	1	1	NUM
aji-177	151	18	,	,	PUNCT
aji-177	151	19	pp	pp	ADJ
aji-177	151	20	.	.	PUNCT
aji-177	152	1	257	257	NUM
aji-177	152	2	-	-	SYM
aji-177	152	3	268	268	NUM
aji-177	152	4	,	,	PUNCT
aji-177	152	5	2025	2025	NUM
aji-177	152	6	;	;	PUNCT
aji-177	152	7	article	article	NOUN
aji-177	152	8	no.aji.147982	no.aji.147982	VERB
aji-177	152	9	260	260	NUM
aji-177	152	10	table	table	NOUN
aji-177	152	11	1	1	NUM
aji-177	152	12	.	.	PUNCT
aji-177	152	13	key	key	ADJ
aji-177	152	14	classes	class	NOUN
aji-177	152	15	of	of	ADP
aji-177	152	16	microbiota	microbiota	NOUN
aji-177	152	17	-	-	PUNCT
aji-177	152	18	derived	derive	VERB
aji-177	152	19	metabolites	metabolite	NOUN
aji-177	152	20	and	and	CCONJ
aji-177	152	21	their	their	PRON
aji-177	152	22	immunomodulatory	immunomodulatory	ADJ
aji-177	152	23	mechanisms	mechanism	NOUN
aji-177	152	24	metabolite	metabolite	NOUN
aji-177	152	25	class	class	NOUN
aji-177	152	26	key	key	ADJ
aji-177	152	27	examples	example	NOUN
aji-177	152	28	bacterial	bacterial	ADJ
aji-177	152	29	origin	origin	NOUN
aji-177	152	30	/	/	SYM
aji-177	152	31	precursor	precursor	NOUN
aji-177	152	32	primary	primary	ADJ
aji-177	152	33	immunologic	immunologic	ADJ
aji-177	152	34	mechanisms	mechanism	NOUN
aji-177	152	35	impact	impact	NOUN
aji-177	152	36	on	on	ADP
aji-177	152	37	immunity	immunity	NOUN
aji-177	152	38	short	short	ADJ
aji-177	152	39	-	-	PUNCT
aji-177	152	40	chain	chain	NOUN
aji-177	152	41	fatty	fatty	NOUN
aji-177	152	42	acids	acid	NOUN
aji-177	152	43	(	(	PUNCT
aji-177	152	44	scfas	scfas	NOUN
aji-177	152	45	)	)	PUNCT
aji-177	152	46	acetate	acetate	NOUN
aji-177	152	47	,	,	PUNCT
aji-177	152	48	propionate	propionate	NOUN
aji-177	152	49	,	,	PUNCT
aji-177	152	50	butyrate	butyrate	ADJ
aji-177	152	51	fermentation	fermentation	NOUN
aji-177	152	52	of	of	ADP
aji-177	152	53	dietary	dietary	ADJ
aji-177	152	54	fiber	fiber	NOUN
aji-177	152	55	by	by	ADP
aji-177	152	56	genera	genera	NOUN
aji-177	152	57	like	like	ADP
aji-177	152	58	faecalibacterium	faecalibacterium	NOUN
aji-177	152	59	,	,	PUNCT
aji-177	152	60	roseburia	roseburia	NOUN
aji-177	152	61	,	,	PUNCT
aji-177	152	62	lachnospiraceae	lachnospiraceae	INTJ
aji-177	152	63	(	(	PUNCT
aji-177	152	64	mager	mager	PROPN
aji-177	152	65	et	et	PROPN
aji-177	152	66	al	al	PROPN
aji-177	152	67	.	.	PROPN
aji-177	152	68	,	,	PUNCT
aji-177	152	69	2020	2020	NUM
aji-177	152	70	)	)	PUNCT
aji-177	152	71	roseburia	roseburia	NOUN
aji-177	152	72	,	,	PUNCT
aji-177	152	73	lachnospiraceae	lachnospiraceae	INTJ
aji-177	152	74	(	(	PUNCT
aji-177	152	75	mager	mager	PROPN
aji-177	152	76	et	et	PROPN
aji-177	152	77	al	al	PROPN
aji-177	152	78	.	.	PROPN
aji-177	152	79	,	,	PUNCT
aji-177	152	80	2020	2020	NUM
aji-177	152	81	)	)	PUNCT
aji-177	152	82	.	.	PUNCT
aji-177	153	1	hdac	hdac	PROPN
aji-177	153	2	inhibition	inhibition	NOUN
aji-177	153	3	(	(	PUNCT
aji-177	153	4	mager	mager	PROPN
aji-177	153	5	et	et	PROPN
aji-177	153	6	al	al	PROPN
aji-177	153	7	.	.	PROPN
aji-177	153	8	,	,	PUNCT
aji-177	153	9	2020	2020	NUM
aji-177	153	10	)	)	PUNCT
aji-177	153	11	signaling	signal	VERB
aji-177	153	12	via	via	ADP
aji-177	153	13	gpcrs	gpcrs	PROPN
aji-177	153	14	(	(	PUNCT
aji-177	153	15	gpr41	gpr41	PROPN
aji-177	153	16	,	,	PUNCT
aji-177	153	17	gpr43	gpr43	NOUN
aji-177	153	18	,	,	PUNCT
aji-177	153	19	gpr109a	gpr109a	PROPN
aji-177	153	20	)	)	PUNCT
aji-177	153	21	(	(	PUNCT
aji-177	153	22	ayodele	ayodele	PROPN
aji-177	153	23	et	et	PROPN
aji-177	153	24	al	al	PROPN
aji-177	153	25	.	.	PROPN
aji-177	153	26	,	,	PUNCT
aji-177	153	27	2025	2025	NUM
aji-177	153	28	)	)	PUNCT
aji-177	153	29	energy	energy	NOUN
aji-177	153	30	source	source	NOUN
aji-177	153	31	for	for	ADP
aji-177	153	32	colonocytes	colonocyte	NOUN
aji-177	153	33	&	&	CCONJ
aji-177	153	34	immune	immune	ADJ
aji-177	153	35	cells	cell	NOUN
aji-177	153	36	.	.	PUNCT
aji-177	154	1	generally	generally	ADV
aji-177	154	2	anti	anti	ADJ
aji-177	154	3	-	-	ADJ
aji-177	154	4	inflammatory	inflammatory	ADJ
aji-177	154	5	:	:	PUNCT
aji-177	154	6	promote	promote	VERB
aji-177	154	7	treg	treg	PROPN
aji-177	154	8	differentiation	differentiation	PROPN
aji-177	154	9	,	,	PUNCT
aji-177	154	10	maintain	maintain	VERB
aji-177	154	11	gut	gut	NOUN
aji-177	154	12	barrier	barrier	NOUN
aji-177	154	13	integrity	integrity	NOUN
aji-177	154	14	,	,	PUNCT
aji-177	154	15	modulate	modulate	VERB
aji-177	154	16	neutrophil	neutrophil	ADJ
aji-177	154	17	chemotaxis	chemotaxis	ADJ
aji-177	154	18	and	and	CCONJ
aji-177	154	19	function	function	NOUN
aji-177	154	20	.	.	PUNCT
aji-177	155	1	secondary	secondary	ADJ
aji-177	155	2	bile	bile	NOUN
aji-177	155	3	acids	acid	NOUN
aji-177	155	4	deoxycholic	deoxycholic	PROPN
aji-177	155	5	acid	acid	PROPN
aji-177	155	6	(	(	PUNCT
aji-177	155	7	dca	dca	PROPN
aji-177	155	8	)	)	PUNCT
aji-177	155	9	,	,	PUNCT
aji-177	155	10	lithocholic	lithocholic	ADJ
aji-177	155	11	acid	acid	PROPN
aji-177	155	12	(	(	PUNCT
aji-177	155	13	lca	lca	PROPN
aji-177	155	14	)	)	PUNCT
aji-177	155	15	,	,	PUNCT
aji-177	155	16	ursodeoxycholic	ursodeoxycholic	PROPN
aji-177	155	17	acid	acid	PROPN
aji-177	155	18	(	(	PUNCT
aji-177	155	19	udca	udca	NOUN
aji-177	155	20	)	)	PUNCT
aji-177	155	21	bacterial	bacterial	ADJ
aji-177	155	22	dehydroxylation	dehydroxylation	NOUN
aji-177	155	23	of	of	ADP
aji-177	155	24	primary	primary	ADJ
aji-177	155	25	bile	bile	NOUN
aji-177	155	26	acids	acid	NOUN
aji-177	155	27	(	(	PUNCT
aji-177	155	28	cholic	cholic	ADJ
aji-177	155	29	acid	acid	NOUN
aji-177	155	30	,	,	PUNCT
aji-177	155	31	chenodeoxycholic	chenodeoxycholic	ADJ
aji-177	155	32	acid	acid	NOUN
aji-177	155	33	)	)	PUNCT
aji-177	155	34	by	by	ADP
aji-177	155	35	species	specie	NOUN
aji-177	155	36	like	like	ADP
aji-177	155	37	clostridium	clostridium	NOUN
aji-177	155	38	cluster	cluster	NOUN
aji-177	155	39	xiva	xiva	NOUN
aji-177	155	40	(	(	PUNCT
aji-177	155	41	parada	parada	PROPN
aji-177	155	42	venegas	venegas	PROPN
aji-177	155	43	et	et	PROPN
aji-177	155	44	al	al	PROPN
aji-177	155	45	.	.	PROPN
aji-177	155	46	,	,	PUNCT
aji-177	155	47	2019	2019	NUM
aji-177	155	48	)	)	PUNCT
aji-177	155	49	.	.	PUNCT
aji-177	156	1	signaling	signal	VERB
aji-177	156	2	via	via	ADP
aji-177	156	3	nuclear	nuclear	ADJ
aji-177	156	4	receptor	receptor	NOUN
aji-177	156	5	fxr	fxr	PROPN
aji-177	156	6	&	&	CCONJ
aji-177	156	7	membrane	membrane	NOUN
aji-177	156	8	receptor	receptor	NOUN
aji-177	156	9	tgr5	tgr5	NOUN
aji-177	156	10	(	(	PUNCT
aji-177	156	11	ma	ma	PROPN
aji-177	156	12	et	et	PROPN
aji-177	156	13	al	al	PROPN
aji-177	156	14	.	.	PROPN
aji-177	156	15	,	,	PUNCT
aji-177	156	16	2025	2025	NUM
aji-177	156	17	)	)	PUNCT
aji-177	156	18	.	.	PUNCT
aji-177	157	1	context	context	NOUN
aji-177	157	2	-	-	PUNCT
aji-177	157	3	dependent	dependent	ADJ
aji-177	157	4	:	:	PUNCT
aji-177	157	5	can	can	AUX
aji-177	157	6	be	be	AUX
aji-177	157	7	proinflammatory	proinflammatory	ADJ
aji-177	157	8	(	(	PUNCT
aji-177	157	9	dca	dca	PROPN
aji-177	157	10	)	)	PUNCT
aji-177	157	11	or	or	CCONJ
aji-177	157	12	antiinflammatory	antiinflammatory	NOUN
aji-177	157	13	(	(	PUNCT
aji-177	157	14	udca	udca	NOUN
aji-177	157	15	)	)	PUNCT
aji-177	157	16	.	.	PUNCT
aji-177	158	1	regulate	regulate	VERB
aji-177	158	2	metabolic	metabolic	NOUN
aji-177	158	3	homeostasis	homeostasis	NOUN
aji-177	158	4	and	and	CCONJ
aji-177	158	5	macrophage	macrophage	ADJ
aji-177	158	6	differentiation	differentiation	NOUN
aji-177	158	7	.	.	PUNCT
aji-177	159	1	polyamines	polyamine	NOUN
aji-177	159	2	spermidine	spermidine	NOUN
aji-177	159	3	,	,	PUNCT
aji-177	159	4	spermine	spermine	NOUN
aji-177	159	5	,	,	PUNCT
aji-177	159	6	putrescine	putrescine	NOUN
aji-177	159	7	decarboxylation	decarboxylation	NOUN
aji-177	159	8	of	of	ADP
aji-177	159	9	amino	amino	ADJ
aji-177	159	10	acids	acid	NOUN
aji-177	159	11	(	(	PUNCT
aji-177	159	12	e.g.	e.g.	ADV
aji-177	159	13	,	,	PUNCT
aji-177	159	14	arginine	arginine	NOUN
aji-177	159	15	,	,	PUNCT
aji-177	159	16	ornithine	ornithine	NOUN
aji-177	159	17	)	)	PUNCT
aji-177	159	18	by	by	ADP
aji-177	159	19	bacteria	bacteria	NOUN
aji-177	159	20	like	like	ADP
aji-177	159	21	bifidobacterium	bifidobacterium	NOUN
aji-177	159	22	and	and	CCONJ
aji-177	159	23	lactobacillus	lactobacillus	NOUN
aji-177	159	24	(	(	PUNCT
aji-177	159	25	zhang	zhang	X
aji-177	159	26	et	et	PROPN
aji-177	159	27	al	al	PROPN
aji-177	159	28	.	.	PROPN
aji-177	159	29	,	,	PUNCT
aji-177	159	30	2025	2025	NUM
aji-177	159	31	)	)	PUNCT
aji-177	159	32	.	.	PUNCT
aji-177	160	1	regulation	regulation	NOUN
aji-177	160	2	of	of	ADP
aji-177	160	3	autophagy	autophagy	NOUN
aji-177	160	4	,	,	PUNCT
aji-177	160	5	translation	translation	NOUN
aji-177	160	6	(	(	PUNCT
aji-177	160	7	via	via	ADP
aji-177	160	8	hypusination	hypusination	NOUN
aji-177	160	9	)	)	PUNCT
aji-177	160	10	(	(	PUNCT
aji-177	160	11	qi	qi	X
aji-177	160	12	et	et	PROPN
aji-177	160	13	al	al	PROPN
aji-177	160	14	.	.	PROPN
aji-177	160	15	,	,	PUNCT
aji-177	160	16	2025	2025	NUM
aji-177	160	17	)	)	PUNCT
aji-177	160	18	anti	anti	ADJ
aji-177	160	19	-	-	ADJ
aji-177	160	20	oxidant	oxidant	ADJ
aji-177	160	21	effects	effect	NOUN
aji-177	160	22	modulation	modulation	NOUN
aji-177	160	23	of	of	ADP
aji-177	160	24	ion	ion	NOUN
aji-177	160	25	channels	channel	NOUN
aji-177	160	26	.	.	PUNCT
aji-177	161	1	immunomodulatory	immunomodulatory	ADJ
aji-177	161	2	:	:	PUNCT
aji-177	161	3	support	support	VERB
aji-177	161	4	t	t	NOUN
aji-177	161	5	-	-	PUNCT
aji-177	161	6	cell	cell	NOUN
aji-177	161	7	differentiation	differentiation	NOUN
aji-177	161	8	and	and	CCONJ
aji-177	161	9	function	function	NOUN
aji-177	161	10	,	,	PUNCT
aji-177	161	11	suppress	suppress	VERB
aji-177	161	12	pro	pro	ADJ
aji-177	161	13	-	-	ADJ
aji-177	161	14	inflammatory	inflammatory	ADJ
aji-177	161	15	cytokine	cytokine	NOUN
aji-177	161	16	production	production	NOUN
aji-177	161	17	,	,	PUNCT
aji-177	161	18	can	can	AUX
aji-177	161	19	inhibit	inhibit	VERB
aji-177	161	20	netosis	netosis	PRON
aji-177	161	21	.	.	PUNCT
aji-177	162	1	tryptophan	tryptophan	NOUN
aji-177	162	2	catabolites	catabolite	NOUN
aji-177	162	3	indole	indole	NOUN
aji-177	162	4	,	,	PUNCT
aji-177	162	5	indole-3	indole-3	NOUN
aji-177	162	6	-	-	PUNCT
aji-177	162	7	aldehyde	aldehyde	NOUN
aji-177	162	8	,	,	PUNCT
aji-177	162	9	indolepropionic	indolepropionic	ADJ
aji-177	162	10	acid	acid	NOUN
aji-177	162	11	(	(	PUNCT
aji-177	162	12	ipa	ipa	PROPN
aji-177	162	13	)	)	PUNCT
aji-177	162	14	tryptophan	tryptophan	NOUN
aji-177	162	15	metabolism	metabolism	NOUN
aji-177	162	16	by	by	ADP
aji-177	162	17	bacteria	bacteria	NOUN
aji-177	162	18	(	(	PUNCT
aji-177	162	19	e.g.	e.g.	ADV
aji-177	162	20	,	,	PUNCT
aji-177	162	21	lactobacillus	lactobacillus	NOUN
aji-177	162	22	spp	spp	NOUN
aji-177	162	23	.	.	PUNCT
aji-177	162	24	)	)	PUNCT
aji-177	163	1	expressing	express	VERB
aji-177	163	2	tryptophanase	tryptophanase	NOUN
aji-177	163	3	(	(	PUNCT
aji-177	163	4	tofalo	tofalo	PROPN
aji-177	163	5	et	et	PROPN
aji-177	163	6	al	al	PROPN
aji-177	163	7	.	.	PROPN
aji-177	163	8	,	,	PUNCT
aji-177	163	9	2019	2019	NUM
aji-177	163	10	)	)	PUNCT
aji-177	163	11	.	.	PUNCT
aji-177	164	1	activation	activation	NOUN
aji-177	164	2	of	of	ADP
aji-177	164	3	the	the	DET
aji-177	164	4	aryl	aryl	NOUN
aji-177	164	5	hydrocarbon	hydrocarbon	NOUN
aji-177	164	6	receptor	receptor	NOUN
aji-177	164	7	(	(	PUNCT
aji-177	164	8	ahr	ahr	PROPN
aji-177	164	9	)	)	PUNCT
aji-177	164	10	(	(	PUNCT
aji-177	164	11	puleston	puleston	NOUN
aji-177	164	12	et	et	PROPN
aji-177	164	13	al	al	PROPN
aji-177	164	14	.	.	PROPN
aji-177	164	15	,	,	PUNCT
aji-177	164	16	2019	2019	NUM
aji-177	164	17	)	)	PUNCT
aji-177	164	18	.	.	PUNCT
aji-177	165	1	barrier	barrier	NOUN
aji-177	165	2	fortification	fortification	NOUN
aji-177	165	3	&	&	CCONJ
aji-177	165	4	immune	immune	ADJ
aji-177	165	5	regulation	regulation	NOUN
aji-177	165	6	:	:	PUNCT
aji-177	165	7	ahr	ahr	PROPN
aji-177	165	8	activation	activation	NOUN
aji-177	165	9	strengthens	strengthen	VERB
aji-177	165	10	epithelial	epithelial	ADJ
aji-177	165	11	barriers	barrier	NOUN
aji-177	165	12	,	,	PUNCT
aji-177	165	13	modulates	modulate	VERB
aji-177	165	14	th17	th17	NOUN
aji-177	165	15	/	/	SYM
aji-177	165	16	treg	treg	PROPN
aji-177	165	17	balance	balance	NOUN
aji-177	165	18	,	,	PUNCT
aji-177	165	19	and	and	CCONJ
aji-177	165	20	suppresses	suppress	VERB
aji-177	165	21	innate	innate	ADJ
aji-177	165	22	immune	immune	ADJ
aji-177	165	23	activation	activation	NOUN
aji-177	165	24	.	.	PUNCT
aji-177	166	1	other	other	ADJ
aji-177	166	2	bioactive	bioactive	ADJ
aji-177	166	3	metabolites	metabolite	NOUN
aji-177	166	4	inosine	inosine	NOUN
aji-177	166	5	,	,	PUNCT
aji-177	166	6	d	d	NOUN
aji-177	166	7	-	-	PUNCT
aji-177	166	8	lactate	lactate	ADJ
aji-177	166	9	,	,	PUNCT
aji-177	166	10	trimethylamine	trimethylamine	NOUN
aji-177	166	11	n	n	CCONJ
aji-177	166	12	-	-	PUNCT
aji-177	166	13	oxide	oxide	NOUN
aji-177	166	14	(	(	PUNCT
aji-177	166	15	tmao	tmao	PROPN
aji-177	166	16	)	)	PUNCT
aji-177	166	17	purine	purine	NOUN
aji-177	166	18	metabolism	metabolism	NOUN
aji-177	166	19	(	(	PUNCT
aji-177	166	20	inosine	inosine	NOUN
aji-177	166	21	)	)	PUNCT
aji-177	166	22	,	,	PUNCT
aji-177	166	23	fermentation	fermentation	NOUN
aji-177	166	24	(	(	PUNCT
aji-177	166	25	d	d	NOUN
aji-177	166	26	-	-	PUNCT
aji-177	166	27	lactate	lactate	NOUN
aji-177	166	28	)	)	PUNCT
aji-177	166	29	,	,	PUNCT
aji-177	166	30	choline	choline	NOUN
aji-177	166	31	/	/	SYM
aji-177	166	32	carnitine	carnitine	NOUN
aji-177	166	33	metabolism	metabolism	NOUN
aji-177	166	34	(	(	PUNCT
aji-177	166	35	tmao	tmao	PROPN
aji-177	166	36	)	)	PUNCT
aji-177	166	37	.	.	PUNCT
aji-177	167	1	adenosine	adenosine	VERB
aji-177	167	2	a2a	a2a	PROPN
aji-177	167	3	receptor	receptor	NOUN
aji-177	167	4	signaling	signal	VERB
aji-177	167	5	(	(	PUNCT
aji-177	167	6	inosine	inosine	NOUN
aji-177	167	7	)	)	PUNCT
aji-177	167	8	(	(	PUNCT
aji-177	167	9	kullberg	kullberg	PROPN
aji-177	167	10	et	et	PROPN
aji-177	167	11	al	al	PROPN
aji-177	167	12	.	.	PROPN
aji-177	167	13	,	,	PUNCT
aji-177	167	14	2025	2025	NUM
aji-177	167	15	)	)	PUNCT
aji-177	167	16	precursor	precursor	NOUN
aji-177	167	17	to	to	ADP
aji-177	167	18	pro	pro	ADJ
aji-177	167	19	-	-	ADJ
aji-177	167	20	atherogenic	atherogenic	ADJ
aji-177	167	21	tmao	tmao	NOUN
aji-177	167	22	.	.	PUNCT
aji-177	168	1	variable	variable	NOUN
aji-177	168	2	:	:	PUNCT
aji-177	168	3	inosine	inosine	NOUN
aji-177	168	4	enhances	enhance	VERB
aji-177	168	5	th1	th1	NOUN
aji-177	168	6	differentiation	differentiation	NOUN
aji-177	168	7	and	and	CCONJ
aji-177	168	8	icb	icb	PROPN
aji-177	168	9	response	response	NOUN
aji-177	168	10	;	;	PUNCT
aji-177	168	11	tmao	tmao	PROPN
aji-177	168	12	is	be	AUX
aji-177	168	13	generally	generally	ADV
aji-177	168	14	pro	pro	ADJ
aji-177	168	15	-	-	ADJ
aji-177	168	16	inflammatory	inflammatory	ADJ
aji-177	168	17	and	and	CCONJ
aji-177	168	18	linked	link	VERB
aji-177	168	19	to	to	ADP
aji-177	168	20	cardiovascular	cardiovascular	ADJ
aji-177	168	21	disease	disease	NOUN
aji-177	168	22	.	.	PUNCT
aji-177	169	1	jimoh	jimoh	PROPN
aji-177	169	2	et	et	PROPN
aji-177	169	3	al	al	PROPN
aji-177	169	4	.	.	PROPN
aji-177	169	5	;	;	PUNCT
aji-177	169	6	asian	asian	PROPN
aji-177	169	7	j.	j.	PROPN
aji-177	169	8	immunol	immunol	PROPN
aji-177	169	9	.	.	PROPN
aji-177	169	10	,	,	PUNCT
aji-177	169	11	vol	vol	NOUN
aji-177	169	12	.	.	PROPN
aji-177	169	13	8	8	NUM
aji-177	169	14	,	,	PUNCT
aji-177	169	15	no	no	INTJ
aji-177	169	16	.	.	NOUN
aji-177	169	17	1	1	NUM
aji-177	169	18	,	,	PUNCT
aji-177	169	19	pp	pp	ADJ
aji-177	169	20	.	.	PUNCT
aji-177	170	1	257	257	NUM
aji-177	170	2	-	-	SYM
aji-177	170	3	268	268	NUM
aji-177	170	4	,	,	PUNCT
aji-177	170	5	2025	2025	NUM
aji-177	170	6	;	;	PUNCT
aji-177	170	7	article	article	NOUN
aji-177	170	8	no.aji.147982	no.aji.147982	VERB
aji-177	170	9	261	261	NUM
aji-177	170	10	2.1	2.1	NUM
aji-177	170	11	short	short	ADJ
aji-177	170	12	-	-	PUNCT
aji-177	170	13	chain	chain	NOUN
aji-177	170	14	fatty	fatty	NOUN
aji-177	170	15	acids	acid	NOUN
aji-177	170	16	(	(	PUNCT
aji-177	170	17	scfas	scfas	ADV
aji-177	170	18	):	):	PUNCT
aji-177	170	19	microbial	microbial	ADJ
aji-177	170	20	fermentation	fermentation	NOUN
aji-177	170	21	products	product	NOUN
aji-177	170	22	with	with	ADP
aji-177	170	23	systemic	systemic	ADJ
aji-177	170	24	reach	reach	NOUN
aji-177	170	25	scfas	scfas	NOUN
aji-177	170	26	are	be	AUX
aji-177	170	27	the	the	DET
aji-177	170	28	most	most	ADV
aji-177	170	29	extensively	extensively	ADV
aji-177	170	30	studied	study	VERB
aji-177	170	31	microbial	microbial	ADJ
aji-177	170	32	metabolites	metabolite	NOUN
aji-177	170	33	.	.	PUNCT
aji-177	171	1	butyrate	butyrate	NOUN
aji-177	171	2	is	be	AUX
aji-177	171	3	a	a	DET
aji-177	171	4	primary	primary	ADJ
aji-177	171	5	energy	energy	NOUN
aji-177	171	6	source	source	NOUN
aji-177	171	7	for	for	ADP
aji-177	171	8	colonocytes	colonocyte	NOUN
aji-177	171	9	,	,	PUNCT
aji-177	171	10	crucially	crucially	ADV
aji-177	171	11	maintaining	maintain	VERB
aji-177	171	12	gut	gut	NOUN
aji-177	171	13	barrier	barrier	NOUN
aji-177	171	14	function	function	NOUN
aji-177	171	15	and	and	CCONJ
aji-177	171	16	preventing	prevent	VERB
aji-177	171	17	systemic	systemic	ADJ
aji-177	171	18	inflammation	inflammation	NOUN
aji-177	171	19	.	.	PUNCT
aji-177	172	1	beyond	beyond	ADP
aji-177	172	2	this	this	DET
aji-177	172	3	local	local	ADJ
aji-177	172	4	role	role	NOUN
aji-177	172	5	,	,	PUNCT
aji-177	172	6	scfas	scfas	NOUN
aji-177	172	7	function	function	NOUN
aji-177	172	8	as	as	ADP
aji-177	172	9	potent	potent	ADJ
aji-177	172	10	epigenetic	epigenetic	ADJ
aji-177	172	11	regulators	regulator	NOUN
aji-177	172	12	via	via	ADP
aji-177	172	13	hdac	hdac	NOUN
aji-177	172	14	inhibition	inhibition	NOUN
aji-177	172	15	,	,	PUNCT
aji-177	172	16	leading	lead	VERB
aji-177	172	17	to	to	ADP
aji-177	172	18	increased	increase	VERB
aji-177	172	19	histone	histone	NOUN
aji-177	172	20	acetylation	acetylation	NOUN
aji-177	172	21	and	and	CCONJ
aji-177	172	22	altered	alter	VERB
aji-177	172	23	gene	gene	NOUN
aji-177	172	24	expression	expression	NOUN
aji-177	172	25	in	in	ADP
aji-177	172	26	immune	immune	ADJ
aji-177	172	27	cells	cell	NOUN
aji-177	172	28	(	(	PUNCT
aji-177	172	29	ajibola	ajibola	PROPN
aji-177	172	30	and	and	CCONJ
aji-177	172	31	ayodele	ayodele	PROPN
aji-177	172	32	,	,	PUNCT
aji-177	172	33	2025	2025	NUM
aji-177	172	34	,	,	PUNCT
aji-177	172	35	mager	mager	PROPN
aji-177	172	36	et	et	PROPN
aji-177	172	37	al	al	PROPN
aji-177	172	38	.	.	PROPN
aji-177	172	39	,	,	PUNCT
aji-177	172	40	2020	2020	NUM
aji-177	172	41	)	)	PUNCT
aji-177	172	42	.	.	PUNCT
aji-177	173	1	this	this	DET
aji-177	173	2	mechanism	mechanism	NOUN
aji-177	173	3	promotes	promote	VERB
aji-177	173	4	the	the	DET
aji-177	173	5	differentiation	differentiation	NOUN
aji-177	173	6	of	of	ADP
aji-177	173	7	regulatory	regulatory	ADJ
aji-177	173	8	t	t	NOUN
aji-177	173	9	cells	cell	NOUN
aji-177	173	10	(	(	PUNCT
aji-177	173	11	tregs	treg	NOUN
aji-177	173	12	)	)	PUNCT
aji-177	173	13	,	,	PUNCT
aji-177	173	14	which	which	PRON
aji-177	173	15	are	be	AUX
aji-177	173	16	critical	critical	ADJ
aji-177	173	17	for	for	ADP
aji-177	173	18	maintaining	maintain	VERB
aji-177	173	19	immune	immune	ADJ
aji-177	173	20	tolerance	tolerance	NOUN
aji-177	173	21	.	.	PUNCT
aji-177	174	1	scfa	scfa	PROPN
aji-177	174	2	signaling	signal	VERB
aji-177	174	3	through	through	ADP
aji-177	174	4	gpcrs	gpcrs	PROPN
aji-177	174	5	like	like	ADP
aji-177	174	6	gpr43	gpr43	NOUN
aji-177	174	7	on	on	ADP
aji-177	174	8	neutrophils	neutrophil	NOUN
aji-177	174	9	can	can	AUX
aji-177	174	10	also	also	ADV
aji-177	174	11	dampen	dampen	VERB
aji-177	174	12	their	their	PRON
aji-177	174	13	inflammatory	inflammatory	ADJ
aji-177	174	14	potential	potential	NOUN
aji-177	174	15	and	and	CCONJ
aji-177	174	16	chemotaxis	chemotaxis	ADJ
aji-177	174	17	,	,	PUNCT
aji-177	174	18	representing	represent	VERB
aji-177	174	19	a	a	DET
aji-177	174	20	direct	direct	ADJ
aji-177	174	21	pathway	pathway	NOUN
aji-177	174	22	for	for	ADP
aji-177	174	23	systemic	systemic	ADJ
aji-177	174	24	immunomodulation	immunomodulation	NOUN
aji-177	174	25	relevant	relevant	ADJ
aji-177	174	26	to	to	ADP
aji-177	174	27	netosis	netosis	PROPN
aji-177	174	28	(	(	PUNCT
aji-177	174	29	ayodele	ayodele	PROPN
aji-177	174	30	et	et	PROPN
aji-177	174	31	al	al	PROPN
aji-177	174	32	.	.	PROPN
aji-177	174	33	,	,	PUNCT
aji-177	174	34	2025	2025	NUM
aji-177	174	35	)	)	PUNCT
aji-177	174	36	.	.	PUNCT
aji-177	175	1	2.2	2.2	NUM
aji-177	175	2	secondary	secondary	ADJ
aji-177	175	3	bile	bile	NOUN
aji-177	175	4	acids	acid	NOUN
aji-177	175	5	(	(	PUNCT
aji-177	175	6	bas	bas	X
aji-177	175	7	):	):	PUNCT
aji-177	175	8	from	from	ADP
aji-177	175	9	digestion	digestion	NOUN
aji-177	175	10	to	to	ADP
aji-177	175	11	immunomodulation	immunomodulation	NOUN
aji-177	175	12	primary	primary	ADJ
aji-177	175	13	bile	bile	NOUN
aji-177	175	14	acids	acid	NOUN
aji-177	175	15	,	,	PUNCT
aji-177	175	16	synthesized	synthesize	VERB
aji-177	175	17	in	in	ADP
aji-177	175	18	the	the	DET
aji-177	175	19	liver	liver	NOUN
aji-177	175	20	,	,	PUNCT
aji-177	175	21	are	be	AUX
aji-177	175	22	transformed	transform	VERB
aji-177	175	23	into	into	ADP
aji-177	175	24	secondary	secondary	ADJ
aji-177	175	25	bile	bile	NOUN
aji-177	175	26	acids	acid	NOUN
aji-177	175	27	by	by	ADP
aji-177	175	28	gut	gut	NOUN
aji-177	175	29	bacteria	bacteria	NOUN
aji-177	175	30	.	.	PUNCT
aji-177	176	1	this	this	DET
aji-177	176	2	process	process	NOUN
aji-177	176	3	significantly	significantly	ADV
aji-177	176	4	alters	alter	VERB
aji-177	176	5	their	their	PRON
aji-177	176	6	signaling	signal	VERB
aji-177	176	7	properties	property	NOUN
aji-177	176	8	.	.	PUNCT
aji-177	177	1	secondary	secondary	ADJ
aji-177	177	2	bas	bas	PROPN
aji-177	177	3	act	act	PROPN
aji-177	177	4	as	as	ADP
aji-177	177	5	signaling	signal	VERB
aji-177	177	6	molecules	molecule	NOUN
aji-177	177	7	through	through	ADP
aji-177	177	8	the	the	DET
aji-177	177	9	nuclear	nuclear	ADJ
aji-177	177	10	receptor	receptor	NOUN
aji-177	177	11	fxr	fxr	NOUN
aji-177	177	12	and	and	CCONJ
aji-177	177	13	the	the	DET
aji-177	177	14	g	g	NOUN
aji-177	177	15	-	-	PUNCT
aji-177	177	16	protein	protein	NOUN
aji-177	177	17	-	-	PUNCT
aji-177	177	18	coupled	couple	VERB
aji-177	177	19	receptor	receptor	NOUN
aji-177	177	20	tgr5	tgr5	NOUN
aji-177	177	21	,	,	PUNCT
aji-177	177	22	regulating	regulate	VERB
aji-177	177	23	not	not	PART
aji-177	177	24	only	only	ADV
aji-177	177	25	metabolic	metabolic	NOUN
aji-177	177	26	homeostasis	homeostasis	NOUN
aji-177	177	27	but	but	CCONJ
aji-177	177	28	also	also	ADV
aji-177	177	29	immune	immune	ADJ
aji-177	177	30	cell	cell	NOUN
aji-177	177	31	function	function	NOUN
aji-177	177	32	(	(	PUNCT
aji-177	177	33	ma	ma	PROPN
aji-177	177	34	et	et	PROPN
aji-177	177	35	al	al	PROPN
aji-177	177	36	.	.	PROPN
aji-177	177	37	,	,	PUNCT
aji-177	177	38	2025	2025	NUM
aji-177	177	39	)	)	PUNCT
aji-177	177	40	.	.	PUNCT
aji-177	178	1	for	for	ADP
aji-177	178	2	instance	instance	NOUN
aji-177	178	3	,	,	PUNCT
aji-177	178	4	specific	specific	ADJ
aji-177	178	5	secondary	secondary	ADJ
aji-177	178	6	bas	bas	PROPN
aji-177	178	7	can	can	AUX
aji-177	178	8	promote	promote	VERB
aji-177	178	9	the	the	DET
aji-177	178	10	differentiation	differentiation	NOUN
aji-177	178	11	of	of	ADP
aji-177	178	12	anti	anti	ADJ
aji-177	178	13	-	-	ADJ
aji-177	178	14	inflammatory	inflammatory	ADJ
aji-177	178	15	macrophages	macrophage	NOUN
aji-177	178	16	,	,	PUNCT
aji-177	178	17	while	while	SCONJ
aji-177	178	18	others	other	NOUN
aji-177	178	19	,	,	PUNCT
aji-177	178	20	in	in	ADP
aji-177	178	21	excess	excess	NOUN
aji-177	178	22	,	,	PUNCT
aji-177	178	23	can	can	AUX
aji-177	178	24	be	be	AUX
aji-177	178	25	cytotoxic	cytotoxic	ADJ
aji-177	178	26	and	and	CCONJ
aji-177	178	27	induce	induce	VERB
aji-177	178	28	inflammatory	inflammatory	ADJ
aji-177	178	29	stress	stress	NOUN
aji-177	178	30	responses	response	NOUN
aji-177	178	31	.	.	PUNCT
aji-177	179	1	2.3	2.3	NUM
aji-177	179	2	polyamines	polyamine	NOUN
aji-177	179	3	:	:	PUNCT
aji-177	179	4	crucial	crucial	ADJ
aji-177	179	5	for	for	ADP
aji-177	179	6	cellular	cellular	ADJ
aji-177	179	7	and	and	CCONJ
aji-177	179	8	immune	immune	ADJ
aji-177	179	9	homeostasis	homeostasis	NOUN
aji-177	179	10	polyamines	polyamine	NOUN
aji-177	179	11	are	be	AUX
aji-177	179	12	essential	essential	ADJ
aji-177	179	13	for	for	ADP
aji-177	179	14	cell	cell	NOUN
aji-177	179	15	proliferation	proliferation	NOUN
aji-177	179	16	and	and	CCONJ
aji-177	179	17	are	be	AUX
aji-177	179	18	produced	produce	VERB
aji-177	179	19	by	by	ADP
aji-177	179	20	both	both	PRON
aji-177	179	21	mammalian	mammalian	ADJ
aji-177	179	22	cells	cell	NOUN
aji-177	179	23	and	and	CCONJ
aji-177	179	24	gut	gut	NOUN
aji-177	179	25	bacteria	bacteria	NOUN
aji-177	179	26	.	.	PUNCT
aji-177	180	1	bacterial	bacterial	ADJ
aji-177	180	2	-	-	PUNCT
aji-177	180	3	derived	derive	VERB
aji-177	180	4	polyamines	polyamine	NOUN
aji-177	180	5	can	can	AUX
aji-177	180	6	influence	influence	VERB
aji-177	180	7	host	host	NOUN
aji-177	180	8	immunity	immunity	NOUN
aji-177	180	9	by	by	ADP
aji-177	180	10	modulating	modulate	VERB
aji-177	180	11	autophagy	autophagy	NOUN
aji-177	180	12	,	,	PUNCT
aji-177	180	13	a	a	DET
aji-177	180	14	process	process	NOUN
aji-177	180	15	critical	critical	ADJ
aji-177	180	16	for	for	ADP
aji-177	180	17	immune	immune	ADJ
aji-177	180	18	cell	cell	NOUN
aji-177	180	19	function	function	NOUN
aji-177	180	20	and	and	CCONJ
aji-177	180	21	antigen	antigen	ADJ
aji-177	180	22	presentation	presentation	NOUN
aji-177	180	23	(	(	PUNCT
aji-177	180	24	qi	qi	X
aji-177	180	25	et	et	NOUN
aji-177	180	26	al	al	PROPN
aji-177	180	27	.	.	PROPN
aji-177	180	28	,	,	PUNCT
aji-177	180	29	2025	2025	NUM
aji-177	180	30	)	)	PUNCT
aji-177	180	31	.	.	PUNCT
aji-177	181	1	spermidine	spermidine	NOUN
aji-177	181	2	,	,	PUNCT
aji-177	181	3	in	in	ADP
aji-177	181	4	particular	particular	ADJ
aji-177	181	5	,	,	PUNCT
aji-177	181	6	has	have	AUX
aji-177	181	7	been	be	AUX
aji-177	181	8	shown	show	VERB
aji-177	181	9	to	to	PART
aji-177	181	10	have	have	VERB
aji-177	181	11	anti	anti	ADJ
aji-177	181	12	-	-	ADJ
aji-177	181	13	inflammatory	inflammatory	ADJ
aji-177	181	14	and	and	CCONJ
aji-177	181	15	life	life	NOUN
aji-177	181	16	-	-	PUNCT
aji-177	181	17	spanextending	spanextending	NOUN
aji-177	181	18	effects	effect	NOUN
aji-177	181	19	,	,	PUNCT
aji-177	181	20	partly	partly	ADV
aji-177	181	21	through	through	ADP
aji-177	181	22	its	its	PRON
aji-177	181	23	ability	ability	NOUN
aji-177	181	24	to	to	PART
aji-177	181	25	induce	induce	VERB
aji-177	181	26	autophagy	autophagy	ADV
aji-177	181	27	and	and	CCONJ
aji-177	181	28	suppress	suppress	VERB
aji-177	181	29	oxidative	oxidative	ADJ
aji-177	181	30	stress	stress	NOUN
aji-177	181	31	.	.	PUNCT
aji-177	182	1	2.4	2.4	NUM
aji-177	182	2	tryptophan	tryptophan	NOUN
aji-177	182	3	metabolites	metabolite	NOUN
aji-177	182	4	:	:	PUNCT
aji-177	182	5	ahr	ahr	PROPN
aji-177	182	6	ligands	ligand	NOUN
aji-177	182	7	and	and	CCONJ
aji-177	182	8	barrier	barrier	NOUN
aji-177	182	9	regulators	regulator	NOUN
aji-177	182	10	gut	gut	VERB
aji-177	182	11	bacteria	bacteria	NOUN
aji-177	182	12	that	that	PRON
aji-177	182	13	metabolize	metabolize	VERB
aji-177	182	14	the	the	DET
aji-177	182	15	essential	essential	ADJ
aji-177	182	16	amino	amino	NOUN
aji-177	182	17	acid	acid	NOUN
aji-177	182	18	tryptophan	tryptophan	NOUN
aji-177	182	19	into	into	ADP
aji-177	182	20	ligands	ligand	NOUN
aji-177	182	21	for	for	ADP
aji-177	182	22	the	the	DET
aji-177	182	23	ahr	ahr	PROPN
aji-177	182	24	play	play	VERB
aji-177	182	25	a	a	DET
aji-177	182	26	vital	vital	ADJ
aji-177	182	27	role	role	NOUN
aji-177	182	28	in	in	ADP
aji-177	182	29	immune	immune	ADJ
aji-177	182	30	education	education	NOUN
aji-177	182	31	and	and	CCONJ
aji-177	182	32	barrier	barrier	NOUN
aji-177	182	33	integrity	integrity	NOUN
aji-177	182	34	.	.	PUNCT
aji-177	183	1	ahr	ahr	PROPN
aji-177	183	2	activation	activation	NOUN
aji-177	183	3	in	in	ADP
aji-177	183	4	intestinal	intestinal	ADJ
aji-177	183	5	epithelial	epithelial	ADJ
aji-177	183	6	cells	cell	NOUN
aji-177	183	7	and	and	CCONJ
aji-177	183	8	intraepithelial	intraepithelial	ADJ
aji-177	183	9	lymphocytes	lymphocyte	NOUN
aji-177	183	10	strengthens	strengthen	VERB
aji-177	183	11	the	the	DET
aji-177	183	12	mucosal	mucosal	NOUN
aji-177	183	13	barrier	barrier	NOUN
aji-177	183	14	and	and	CCONJ
aji-177	183	15	helps	help	VERB
aji-177	183	16	maintain	maintain	VERB
aji-177	183	17	a	a	DET
aji-177	183	18	balanced	balanced	ADJ
aji-177	183	19	immune	immune	ADJ
aji-177	183	20	response	response	NOUN
aji-177	183	21	,	,	PUNCT
aji-177	183	22	preventing	prevent	VERB
aji-177	183	23	aberrant	aberrant	ADJ
aji-177	183	24	inflammation	inflammation	NOUN
aji-177	183	25	(	(	PUNCT
aji-177	183	26	puleston	puleston	NOUN
aji-177	183	27	et	et	PROPN
aji-177	183	28	al	al	PROPN
aji-177	183	29	.	.	PROPN
aji-177	183	30	,	,	PUNCT
aji-177	183	31	2019	2019	NUM
aji-177	183	32	)	)	PUNCT
aji-177	183	33	.	.	PUNCT
aji-177	184	1	the	the	DET
aji-177	184	2	systemic	systemic	ADJ
aji-177	184	3	immunologic	immunologic	ADJ
aji-177	184	4	impact	impact	NOUN
aji-177	184	5	of	of	ADP
aji-177	184	6	these	these	DET
aji-177	184	7	metabolites	metabolite	NOUN
aji-177	184	8	is	be	AUX
aji-177	184	9	an	an	DET
aji-177	184	10	area	area	NOUN
aji-177	184	11	of	of	ADP
aji-177	184	12	active	active	ADJ
aji-177	184	13	investigation	investigation	NOUN
aji-177	184	14	.	.	PUNCT
aji-177	185	1	the	the	DET
aji-177	185	2	gut	gut	NOUN
aji-177	185	3	microbial	microbial	ADJ
aji-177	185	4	metabolome	metabolome	NOUN
aji-177	185	5	constitutes	constitute	VERB
aji-177	185	6	a	a	DET
aji-177	185	7	critical	critical	ADJ
aji-177	185	8	interface	interface	NOUN
aji-177	185	9	between	between	ADP
aji-177	185	10	the	the	DET
aji-177	185	11	external	external	ADJ
aji-177	185	12	environment	environment	NOUN
aji-177	185	13	and	and	CCONJ
aji-177	185	14	the	the	DET
aji-177	185	15	host	host	NOUN
aji-177	185	16	immune	immune	ADJ
aji-177	185	17	system	system	NOUN
aji-177	185	18	.	.	PUNCT
aji-177	186	1	the	the	DET
aji-177	186	2	balance	balance	NOUN
aji-177	186	3	and	and	CCONJ
aji-177	186	4	composition	composition	NOUN
aji-177	186	5	of	of	ADP
aji-177	186	6	these	these	DET
aji-177	186	7	metabolites	metabolite	NOUN
aji-177	186	8	directly	directly	ADV
aji-177	186	9	influence	influence	VERB
aji-177	186	10	the	the	DET
aji-177	186	11	functional	functional	ADJ
aji-177	186	12	state	state	NOUN
aji-177	186	13	of	of	ADP
aji-177	186	14	innate	innate	ADJ
aji-177	186	15	and	and	CCONJ
aji-177	186	16	adaptive	adaptive	ADJ
aji-177	186	17	immune	immune	ADJ
aji-177	186	18	cells	cell	NOUN
aji-177	186	19	,	,	PUNCT
aji-177	186	20	creating	create	VERB
aji-177	186	21	a	a	DET
aji-177	186	22	systemic	systemic	ADJ
aji-177	186	23	milieu	milieu	NOUN
aji-177	186	24	that	that	PRON
aji-177	186	25	can	can	AUX
aji-177	186	26	either	either	CCONJ
aji-177	186	27	favor	favor	VERB
aji-177	186	28	or	or	CCONJ
aji-177	186	29	suppress	suppress	VERB
aji-177	186	30	antitumor	antitumor	NOUN
aji-177	186	31	immunity	immunity	NOUN
aji-177	186	32	.	.	PUNCT
aji-177	187	1	the	the	DET
aji-177	187	2	subsequent	subsequent	ADJ
aji-177	187	3	sections	section	NOUN
aji-177	187	4	will	will	AUX
aji-177	187	5	delve	delve	VERB
aji-177	187	6	into	into	ADP
aji-177	187	7	how	how	SCONJ
aji-177	187	8	these	these	DET
aji-177	187	9	specific	specific	ADJ
aji-177	187	10	metabolites	metabolite	NOUN
aji-177	187	11	interact	interact	VERB
aji-177	187	12	with	with	ADP
aji-177	187	13	the	the	DET
aji-177	187	14	process	process	NOUN
aji-177	187	15	of	of	ADP
aji-177	187	16	netosis	netosis	NOUN
aji-177	187	17	to	to	PART
aji-177	187	18	shape	shape	VERB
aji-177	187	19	this	this	DET
aji-177	187	20	immunologic	immunologic	ADJ
aji-177	187	21	landscape	landscape	NOUN
aji-177	187	22	(	(	PUNCT
aji-177	187	23	puleston	puleston	NOUN
aji-177	187	24	et	et	PROPN
aji-177	187	25	al	al	PROPN
aji-177	187	26	.	.	PROPN
aji-177	187	27	,	,	PUNCT
aji-177	187	28	2019	2019	NUM
aji-177	187	29	)	)	PUNCT
aji-177	187	30	.	.	PUNCT
aji-177	188	1	3	3	X
aji-177	188	2	.	.	X
aji-177	188	3	mechanistic	mechanistic	ADJ
aji-177	188	4	interplay	interplay	NOUN
aji-177	188	5	:	:	PUNCT
aji-177	188	6	microbial	microbial	ADJ
aji-177	188	7	metabolites	metabolite	NOUN
aji-177	188	8	as	as	ADP
aji-177	188	9	regulators	regulator	NOUN
aji-177	188	10	of	of	ADP
aji-177	188	11	netosis	netosis	NOUN
aji-177	188	12	the	the	DET
aji-177	188	13	central	central	ADJ
aji-177	188	14	hypothesis	hypothesis	NOUN
aji-177	188	15	of	of	ADP
aji-177	188	16	the	the	DET
aji-177	188	17	gut	gut	NOUN
aji-177	188	18	-	-	PUNCT
aji-177	188	19	net	net	NOUN
aji-177	188	20	-	-	PUNCT
aji-177	188	21	icb	icb	NOUN
aji-177	188	22	axis	axis	NOUN
aji-177	188	23	posits	posit	NOUN
aji-177	188	24	that	that	PRON
aji-177	188	25	gut	gut	VERB
aji-177	188	26	microbial	microbial	ADJ
aji-177	188	27	metabolites	metabolite	NOUN
aji-177	188	28	systemically	systemically	ADV
aji-177	188	29	influence	influence	VERB
aji-177	188	30	the	the	DET
aji-177	188	31	propensity	propensity	NOUN
aji-177	188	32	of	of	ADP
aji-177	188	33	neutrophils	neutrophil	NOUN
aji-177	188	34	to	to	PART
aji-177	188	35	undergo	undergo	VERB
aji-177	188	36	netosis	netosis	NOUN
aji-177	188	37	,	,	PUNCT
aji-177	188	38	thereby	thereby	ADV
aji-177	188	39	shaping	shape	VERB
aji-177	188	40	the	the	DET
aji-177	188	41	immune	immune	ADJ
aji-177	188	42	landscape	landscape	NOUN
aji-177	188	43	of	of	ADP
aji-177	188	44	the	the	DET
aji-177	188	45	tumor	tumor	NOUN
aji-177	188	46	microenvironment	microenvironment	NOUN
aji-177	188	47	(	(	PUNCT
aji-177	188	48	tme	tme	NOUN
aji-177	188	49	)	)	PUNCT
aji-177	188	50	.	.	PUNCT
aji-177	189	1	this	this	DET
aji-177	189	2	interaction	interaction	NOUN
aji-177	189	3	is	be	AUX
aji-177	189	4	not	not	PART
aji-177	189	5	merely	merely	ADV
aji-177	189	6	correlative	correlative	ADJ
aji-177	189	7	;	;	PUNCT
aji-177	189	8	a	a	DET
aji-177	189	9	growing	grow	VERB
aji-177	189	10	body	body	NOUN
aji-177	189	11	of	of	ADP
aji-177	189	12	evidence	evidence	NOUN
aji-177	189	13	demonstrates	demonstrate	VERB
aji-177	189	14	direct	direct	ADJ
aji-177	189	15	and	and	CCONJ
aji-177	189	16	indirect	indirect	ADJ
aji-177	189	17	mechanistic	mechanistic	ADJ
aji-177	189	18	pathways	pathway	NOUN
aji-177	189	19	through	through	ADP
aji-177	189	20	which	which	PRON
aji-177	189	21	these	these	DET
aji-177	189	22	bacterial	bacterial	ADJ
aji-177	189	23	byproducts	byproduct	NOUN
aji-177	189	24	modulate	modulate	VERB
aji-177	189	25	the	the	DET
aji-177	189	26	molecular	molecular	ADJ
aji-177	189	27	machinery	machinery	NOUN
aji-177	189	28	of	of	ADP
aji-177	189	29	net	net	ADJ
aji-177	189	30	formation	formation	NOUN
aji-177	189	31	.	.	PUNCT
aji-177	190	1	the	the	DET
aji-177	190	2	balance	balance	NOUN
aji-177	190	3	between	between	ADP
aji-177	190	4	netosis	netosis	NOUN
aji-177	190	5	-	-	PUNCT
aji-177	190	6	suppressive	suppressive	NOUN
aji-177	190	7	and	and	CCONJ
aji-177	190	8	netosis	netosis	NOUN
aji-177	190	9	-	-	PUNCT
aji-177	190	10	promoting	promote	VERB
aji-177	190	11	metabolites	metabolite	NOUN
aji-177	190	12	can	can	AUX
aji-177	190	13	critically	critically	ADV
aji-177	190	14	determine	determine	VERB
aji-177	190	15	the	the	DET
aji-177	190	16	outcome	outcome	NOUN
aji-177	190	17	of	of	ADP
aji-177	190	18	anti	anti	ADJ
aji-177	190	19	-	-	ADJ
aji-177	190	20	tumor	tumor	ADJ
aji-177	190	21	immunity	immunity	NOUN
aji-177	190	22	(	(	PUNCT
aji-177	190	23	ma	ma	PROPN
aji-177	190	24	et	et	PROPN
aji-177	190	25	al	al	PROPN
aji-177	190	26	.	.	PROPN
aji-177	190	27	,	,	PUNCT
aji-177	190	28	2025	2025	NUM
aji-177	190	29	)	)	PUNCT
aji-177	190	30	.	.	PUNCT
aji-177	191	1	3.1	3.1	NUM
aji-177	191	2	suppressive	suppressive	ADJ
aji-177	191	3	metabolites	metabolite	NOUN
aji-177	191	4	:	:	PUNCT
aji-177	191	5	scfas	scfas	NOUN
aji-177	191	6	and	and	CCONJ
aji-177	191	7	polyamines	polyamine	NOUN
aji-177	191	8	as	as	SCONJ
aji-177	191	9	netosis	netosis	NOUN
aji-177	191	10	brakes	brake	NOUN
aji-177	191	11	short	short	ADJ
aji-177	191	12	-	-	PUNCT
aji-177	191	13	chain	chain	NOUN
aji-177	191	14	fatty	fatty	NOUN
aji-177	191	15	acids	acid	NOUN
aji-177	191	16	(	(	PUNCT
aji-177	191	17	scfas	scfas	NOUN
aji-177	191	18	):	):	PUNCT
aji-177	191	19	butyrate	butyrate	NOUN
aji-177	191	20	has	have	AUX
aji-177	191	21	been	be	AUX
aji-177	191	22	demonstrated	demonstrate	VERB
aji-177	191	23	to	to	PART
aji-177	191	24	robustly	robustly	ADV
aji-177	191	25	inhibit	inhibit	VERB
aji-177	191	26	netosis	netosis	NOUN
aji-177	191	27	induced	induce	VERB
aji-177	191	28	by	by	ADP
aji-177	191	29	various	various	ADJ
aji-177	191	30	stimuli	stimulus	NOUN
aji-177	191	31	,	,	PUNCT
aji-177	191	32	including	include	VERB
aji-177	191	33	pma	pma	NOUN
aji-177	191	34	and	and	CCONJ
aji-177	191	35	lps	lps	PROPN
aji-177	191	36	,	,	PUNCT
aji-177	191	37	in	in	ADP
aji-177	191	38	human	human	ADJ
aji-177	191	39	neutrophils	neutrophil	NOUN
aji-177	191	40	in	in	ADP
aji-177	191	41	vitro	vitro	X
aji-177	191	42	(	(	PUNCT
aji-177	191	43	zhang	zhang	X
aji-177	191	44	et	et	PROPN
aji-177	191	45	al	al	PROPN
aji-177	191	46	.	.	PROPN
aji-177	191	47	,	,	PUNCT
aji-177	191	48	2025	2025	NUM
aji-177	191	49	)	)	PUNCT
aji-177	191	50	.	.	PUNCT
aji-177	192	1	the	the	DET
aji-177	192	2	primary	primary	ADJ
aji-177	192	3	mechanism	mechanism	NOUN
aji-177	192	4	is	be	AUX
aji-177	192	5	epigenetic	epigenetic	ADJ
aji-177	192	6	:	:	PUNCT
aji-177	192	7	as	as	ADP
aji-177	192	8	potent	potent	ADJ
aji-177	192	9	hdac	hdac	NOUN
aji-177	192	10	inhibitors	inhibitor	NOUN
aji-177	192	11	,	,	PUNCT
aji-177	192	12	scfas	scfas	NOUN
aji-177	192	13	lead	lead	NOUN
aji-177	192	14	to	to	ADP
aji-177	192	15	hyperacetylation	hyperacetylation	NOUN
aji-177	192	16	of	of	ADP
aji-177	192	17	histones	histone	NOUN
aji-177	192	18	.	.	PUNCT
aji-177	193	1	this	this	PRON
aji-177	193	2	increased	increase	VERB
aji-177	193	3	negative	negative	ADJ
aji-177	193	4	charge	charge	NOUN
aji-177	193	5	makes	make	VERB
aji-177	193	6	the	the	DET
aji-177	193	7	chromatin	chromatin	NOUN
aji-177	193	8	less	less	ADV
aji-177	193	9	accessible	accessible	ADJ
aji-177	193	10	to	to	ADP
aji-177	193	11	pad4	pad4	NOUN
aji-177	193	12	,	,	PUNCT
aji-177	193	13	thereby	thereby	ADV
aji-177	193	14	preventing	prevent	VERB
aji-177	193	15	the	the	DET
aji-177	193	16	histone	histone	NOUN
aji-177	193	17	citrullination	citrullination	NOUN
aji-177	193	18	that	that	PRON
aji-177	193	19	is	be	AUX
aji-177	193	20	essential	essential	ADJ
aji-177	193	21	for	for	ADP
aji-177	193	22	chromatin	chromatin	NOUN
aji-177	193	23	decondensation	decondensation	NOUN
aji-177	193	24	.	.	PUNCT
aji-177	194	1	furthermore	furthermore	ADV
aji-177	194	2	,	,	PUNCT
aji-177	194	3	scfa	scfa	NOUN
aji-177	194	4	signaling	signal	VERB
aji-177	194	5	through	through	ADP
aji-177	194	6	gpr43	gpr43	NOUN
aji-177	194	7	on	on	ADP
aji-177	194	8	the	the	DET
aji-177	194	9	neutrophil	neutrophil	ADJ
aji-177	194	10	surface	surface	NOUN
aji-177	194	11	directly	directly	ADV
aji-177	194	12	suppresses	suppress	VERB
aji-177	194	13	phorbol	phorbol	NOUN
aji-177	194	14	esterinduced	esterinduce	VERB
aji-177	194	15	ros	ros	PROPN
aji-177	194	16	production	production	NOUN
aji-177	194	17	,	,	PUNCT
aji-177	194	18	dismantling	dismantle	VERB
aji-177	194	19	a	a	DET
aji-177	194	20	critical	critical	ADJ
aji-177	194	21	trigger	trigger	NOUN
aji-177	194	22	for	for	ADP
aji-177	194	23	the	the	DET
aji-177	194	24	netotic	netotic	ADJ
aji-177	194	25	cascade	cascade	NOUN
aji-177	194	26	(	(	PUNCT
aji-177	194	27	cai	cai	X
aji-177	194	28	et	et	PROPN
aji-177	194	29	al	al	PROPN
aji-177	194	30	.	.	PROPN
aji-177	194	31	,	,	PUNCT
aji-177	194	32	2025	2025	NUM
aji-177	194	33	)	)	PUNCT
aji-177	194	34	.	.	PUNCT
aji-177	195	1	jimoh	jimoh	PROPN
aji-177	195	2	et	et	PROPN
aji-177	195	3	al	al	PROPN
aji-177	195	4	.	.	PROPN
aji-177	195	5	;	;	PUNCT
aji-177	195	6	asian	asian	PROPN
aji-177	195	7	j.	j.	PROPN
aji-177	195	8	immunol	immunol	PROPN
aji-177	195	9	.	.	PROPN
aji-177	195	10	,	,	PUNCT
aji-177	195	11	vol	vol	NOUN
aji-177	195	12	.	.	PROPN
aji-177	195	13	8	8	NUM
aji-177	195	14	,	,	PUNCT
aji-177	195	15	no	no	INTJ
aji-177	195	16	.	.	NOUN
aji-177	195	17	1	1	NUM
aji-177	195	18	,	,	PUNCT
aji-177	195	19	pp	pp	ADJ
aji-177	195	20	.	.	PUNCT
aji-177	196	1	257	257	NUM
aji-177	196	2	-	-	SYM
aji-177	196	3	268	268	NUM
aji-177	196	4	,	,	PUNCT
aji-177	196	5	2025	2025	NUM
aji-177	196	6	;	;	PUNCT
aji-177	196	7	article	article	NOUN
aji-177	196	8	no.aji.147982	no.aji.147982	VERB
aji-177	196	9	262	262	NUM
aji-177	196	10	table	table	NOUN
aji-177	196	11	2	2	NUM
aji-177	196	12	.	.	PUNCT
aji-177	197	1	mechanisms	mechanism	NOUN
aji-177	197	2	of	of	ADP
aji-177	197	3	gut	gut	ADJ
aji-177	197	4	microbial	microbial	ADJ
aji-177	197	5	metabolites	metabolite	NOUN
aji-177	197	6	in	in	ADP
aji-177	197	7	regulating	regulate	VERB
aji-177	197	8	netosis	netosis	NOUN
aji-177	197	9	metabolite	metabolite	NOUN
aji-177	197	10	class	class	NOUN
aji-177	197	11	net	net	ADJ
aji-177	197	12	effect	effect	NOUN
aji-177	197	13	on	on	ADP
aji-177	197	14	netosis	netosis	NOUN
aji-177	197	15	direct	direct	ADJ
aji-177	197	16	molecular	molecular	ADJ
aji-177	197	17	mechanisms	mechanism	NOUN
aji-177	197	18	indirect	indirect	ADJ
aji-177	197	19	immunological	immunological	ADJ
aji-177	197	20	mechanisms	mechanism	NOUN
aji-177	197	21	short	short	ADJ
aji-177	197	22	-	-	PUNCT
aji-177	197	23	chain	chain	NOUN
aji-177	197	24	fatty	fatty	NOUN
aji-177	197	25	acids	acid	NOUN
aji-177	197	26	(	(	PUNCT
aji-177	197	27	scfas	scfas	NOUN
aji-177	197	28	)	)	PUNCT
aji-177	197	29	potently	potently	ADV
aji-177	197	30	suppressive	suppressive	ADJ
aji-177	197	31	hdac	hdac	NOUN
aji-177	197	32	inhibition	inhibition	NOUN
aji-177	197	33	:	:	PUNCT
aji-177	197	34	hyperacetylation	hyperacetylation	NOUN
aji-177	197	35	of	of	ADP
aji-177	197	36	histones	histone	NOUN
aji-177	197	37	and	and	CCONJ
aji-177	197	38	other	other	ADJ
aji-177	197	39	proteins	protein	NOUN
aji-177	197	40	interferes	interfere	VERB
aji-177	197	41	with	with	ADP
aji-177	197	42	pad4	pad4	NOUN
aji-177	197	43	activity	activity	NOUN
aji-177	197	44	and	and	CCONJ
aji-177	197	45	chromatin	chromatin	NOUN
aji-177	197	46	decondensation	decondensation	NOUN
aji-177	197	47	(	(	PUNCT
aji-177	197	48	zhang	zhang	PROPN
aji-177	197	49	et	et	PROPN
aji-177	197	50	al	al	PROPN
aji-177	197	51	.	.	PROPN
aji-177	197	52	,	,	PUNCT
aji-177	197	53	2025	2025	NUM
aji-177	197	54	)	)	PUNCT
aji-177	197	55	.	.	PUNCT
aji-177	198	1	gpcr	gpcr	PROPN
aji-177	198	2	(	(	PUNCT
aji-177	198	3	gpr43	gpr43	PROPN
aji-177	198	4	)	)	PUNCT
aji-177	198	5	signaling	signaling	NOUN
aji-177	198	6	:	:	PUNCT
aji-177	198	7	downregulates	downregulate	VERB
aji-177	198	8	nadph	nadph	ADJ
aji-177	198	9	oxidase	oxidase	NOUN
aji-177	198	10	assembly	assembly	NOUN
aji-177	198	11	and	and	CCONJ
aji-177	198	12	ros	ros	PROPN
aji-177	198	13	production	production	NOUN
aji-177	198	14	,	,	PUNCT
aji-177	198	15	a	a	DET
aji-177	198	16	key	key	ADJ
aji-177	198	17	trigger	trigger	NOUN
aji-177	198	18	for	for	ADP
aji-177	198	19	suicidal	suicidal	ADJ
aji-177	198	20	netosis	netosis	PROPN
aji-177	198	21	(	(	PUNCT
aji-177	198	22	cai	cai	X
aji-177	198	23	et	et	PROPN
aji-177	198	24	al	al	PROPN
aji-177	198	25	.	.	PROPN
aji-177	198	26	,	,	PUNCT
aji-177	198	27	2025	2025	NUM
aji-177	198	28	)	)	PUNCT
aji-177	198	29	.	.	PUNCT
aji-177	199	1	inhibition	inhibition	NOUN
aji-177	199	2	of	of	ADP
aji-177	199	3	nf	nf	ADJ
aji-177	199	4	-	-	PUNCT
aji-177	199	5	κb	κb	NOUN
aji-177	199	6	pathway	pathway	NOUN
aji-177	199	7	:	:	PUNCT
aji-177	199	8	reduces	reduce	VERB
aji-177	199	9	transcription	transcription	NOUN
aji-177	199	10	of	of	ADP
aji-177	199	11	proinflammatory	proinflammatory	ADJ
aji-177	199	12	cytokines	cytokine	NOUN
aji-177	199	13	that	that	SCONJ
aji-177	199	14	prime	prime	ADJ
aji-177	199	15	neutrophils	neutrophil	NOUN
aji-177	199	16	.	.	PUNCT
aji-177	200	1	promotes	promote	VERB
aji-177	200	2	differentiation	differentiation	NOUN
aji-177	200	3	of	of	ADP
aji-177	200	4	anti	anti	ADJ
aji-177	200	5	-	-	ADJ
aji-177	200	6	inflammatory	inflammatory	ADJ
aji-177	200	7	tregs	treg	NOUN
aji-177	200	8	,	,	PUNCT
aji-177	200	9	reducing	reduce	VERB
aji-177	200	10	the	the	DET
aji-177	200	11	cytokine	cytokine	NOUN
aji-177	200	12	drive	drive	NOUN
aji-177	200	13	for	for	ADP
aji-177	200	14	netosis	netosis	NOUN
aji-177	200	15	.	.	PUNCT
aji-177	201	1	enhances	enhance	VERB
aji-177	201	2	gut	gut	NOUN
aji-177	201	3	barrier	barrier	NOUN
aji-177	201	4	integrity	integrity	NOUN
aji-177	201	5	,	,	PUNCT
aji-177	201	6	reducing	reduce	VERB
aji-177	201	7	systemic	systemic	ADJ
aji-177	201	8	translocation	translocation	NOUN
aji-177	201	9	of	of	ADP
aji-177	201	10	lps	lps	PROPN
aji-177	201	11	,	,	PUNCT
aji-177	201	12	a	a	DET
aji-177	201	13	potent	potent	ADJ
aji-177	201	14	netosis	netosis	NOUN
aji-177	201	15	inducer	inducer	NOUN
aji-177	201	16	.	.	PUNCT
aji-177	202	1	polyamines	polyamine	NOUN
aji-177	202	2	potently	potently	ADV
aji-177	202	3	suppressive	suppressive	ADJ
aji-177	202	4	direct	direct	ADJ
aji-177	202	5	inhibition	inhibition	NOUN
aji-177	202	6	of	of	ADP
aji-177	202	7	pad4	pad4	NOUN
aji-177	202	8	:	:	PUNCT
aji-177	202	9	competitively	competitively	ADV
aji-177	202	10	binds	bind	VERB
aji-177	202	11	to	to	ADP
aji-177	202	12	the	the	DET
aji-177	202	13	enzyme	enzyme	NOUN
aji-177	202	14	's	's	PART
aji-177	202	15	active	active	ADJ
aji-177	202	16	site	site	NOUN
aji-177	202	17	,	,	PUNCT
aji-177	202	18	preventing	prevent	VERB
aji-177	202	19	histone	histone	NOUN
aji-177	202	20	citrullination	citrullination	NOUN
aji-177	202	21	(	(	PUNCT
aji-177	202	22	perrone	perrone	NOUN
aji-177	202	23	and	and	CCONJ
aji-177	202	24	d'angelo	d'angelo	PROPN
aji-177	202	25	,	,	PUNCT
aji-177	202	26	2025	2025	NUM
aji-177	202	27	)	)	PUNCT
aji-177	202	28	.	.	PUNCT
aji-177	203	1	suppression	suppression	NOUN
aji-177	203	2	of	of	ADP
aji-177	203	3	ros	ros	PROPN
aji-177	203	4	:	:	PUNCT
aji-177	203	5	inhibits	inhibit	VERB
aji-177	203	6	the	the	DET
aji-177	203	7	assembly	assembly	NOUN
aji-177	203	8	and	and	CCONJ
aji-177	203	9	function	function	NOUN
aji-177	203	10	of	of	ADP
aji-177	203	11	the	the	DET
aji-177	203	12	nadph	nadph	ADJ
aji-177	203	13	oxidase	oxidase	NOUN
aji-177	203	14	complex	complex	NOUN
aji-177	203	15	.	.	PUNCT
aji-177	204	1	induction	induction	NOUN
aji-177	204	2	of	of	ADP
aji-177	204	3	autophagy	autophagy	NOUN
aji-177	204	4	:	:	PUNCT
aji-177	204	5	autophagic	autophagic	ADJ
aji-177	204	6	flux	flux	NOUN
aji-177	204	7	can	can	AUX
aji-177	204	8	clear	clear	VERB
aji-177	204	9	damaged	damage	VERB
aji-177	204	10	mitochondria	mitochondria	NOUN
aji-177	204	11	(	(	PUNCT
aji-177	204	12	mitophagy	mitophagy	NOUN
aji-177	204	13	)	)	PUNCT
aji-177	204	14	,	,	PUNCT
aji-177	204	15	preventing	prevent	VERB
aji-177	204	16	mtros	mtro	NOUN
aji-177	204	17	-	-	VERB
aji-177	204	18	induced	induced	ADJ
aji-177	204	19	netosis	netosis	NOUN
aji-177	204	20	(	(	PUNCT
aji-177	204	21	saha	saha	PROPN
aji-177	204	22	and	and	CCONJ
aji-177	204	23	goswami	goswami	PROPN
aji-177	204	24	,	,	PUNCT
aji-177	204	25	2025	2025	NUM
aji-177	204	26	)	)	PUNCT
aji-177	204	27	.	.	PUNCT
aji-177	205	1	modulates	modulate	NOUN
aji-177	205	2	macrophage	macrophage	ADJ
aji-177	205	3	polarization	polarization	NOUN
aji-177	205	4	towards	towards	ADP
aji-177	205	5	an	an	DET
aji-177	205	6	m2	m2	PROPN
aji-177	205	7	-	-	PUNCT
aji-177	205	8	like	like	ADJ
aji-177	205	9	,	,	PUNCT
aji-177	205	10	anti	anti	ADJ
aji-177	205	11	-	-	ADJ
aji-177	205	12	inflammatory	inflammatory	ADJ
aji-177	205	13	phenotype	phenotype	NOUN
aji-177	205	14	.	.	PUNCT
aji-177	206	1	supports	support	VERB
aji-177	206	2	t	t	NOUN
aji-177	206	3	-	-	PUNCT
aji-177	206	4	cell	cell	NOUN
aji-177	206	5	function	function	NOUN
aji-177	206	6	,	,	PUNCT
aji-177	206	7	creating	create	VERB
aji-177	206	8	a	a	DET
aji-177	206	9	cytokine	cytokine	ADJ
aji-177	206	10	milieu	milieu	NOUN
aji-177	206	11	less	less	ADV
aji-177	206	12	conducive	conducive	ADJ
aji-177	206	13	to	to	ADP
aji-177	206	14	persistent	persistent	ADJ
aji-177	206	15	neutrophil	neutrophil	ADJ
aji-177	206	16	activation	activation	NOUN
aji-177	206	17	.	.	PUNCT
aji-177	207	1	tryptophan	tryptophan	NOUN
aji-177	207	2	metabolites	metabolite	NOUN
aji-177	207	3	(	(	PUNCT
aji-177	207	4	ahr	ahr	PROPN
aji-177	207	5	ligands	ligand	NOUN
aji-177	207	6	)	)	PUNCT
aji-177	207	7	suppressive	suppressive	NOUN
aji-177	207	8	ahr	ahr	PROPN
aji-177	207	9	activation	activation	NOUN
aji-177	207	10	:	:	PUNCT
aji-177	207	11	ahr	ahr	PROPN
aji-177	207	12	signaling	signal	VERB
aji-177	207	13	in	in	ADP
aji-177	207	14	neutrophils	neutrophil	NOUN
aji-177	207	15	directly	directly	ADV
aji-177	207	16	upregulates	upregulate	VERB
aji-177	207	17	antiapoptotic	antiapoptotic	ADJ
aji-177	207	18	genes	gene	NOUN
aji-177	207	19	and	and	CCONJ
aji-177	207	20	downregulates	downregulate	VERB
aji-177	207	21	pro	pro	ADJ
aji-177	207	22	-	-	ADJ
aji-177	207	23	inflammatory	inflammatory	ADJ
aji-177	207	24	pathways	pathway	NOUN
aji-177	207	25	,	,	PUNCT
aji-177	207	26	raising	raise	VERB
aji-177	207	27	the	the	DET
aji-177	207	28	activation	activation	NOUN
aji-177	207	29	threshold	threshold	NOUN
aji-177	207	30	for	for	ADP
aji-177	207	31	netosis	netosis	NOUN
aji-177	207	32	(	(	PUNCT
aji-177	207	33	zhao	zhao	PROPN
aji-177	207	34	et	et	PROPN
aji-177	207	35	al	al	PROPN
aji-177	207	36	.	.	PROPN
aji-177	207	37	,	,	PUNCT
aji-177	207	38	2025	2025	NUM
aji-177	207	39	)	)	PUNCT
aji-177	207	40	.	.	PUNCT
aji-177	208	1	ahr	ahr	PROPN
aji-177	208	2	activation	activation	NOUN
aji-177	208	3	in	in	ADP
aji-177	208	4	dendritic	dendritic	ADJ
aji-177	208	5	cells	cell	NOUN
aji-177	208	6	and	and	CCONJ
aji-177	208	7	t	t	NOUN
aji-177	208	8	cells	cell	NOUN
aji-177	208	9	promotes	promote	VERB
aji-177	208	10	immune	immune	ADJ
aji-177	208	11	tolerance	tolerance	NOUN
aji-177	208	12	and	and	CCONJ
aji-177	208	13	a	a	DET
aji-177	208	14	balanced	balanced	ADJ
aji-177	208	15	cytokine	cytokine	ADJ
aji-177	208	16	response	response	NOUN
aji-177	208	17	.	.	PUNCT
aji-177	209	1	strengthening	strengthen	VERB
aji-177	209	2	of	of	ADP
aji-177	209	3	the	the	DET
aji-177	209	4	gut	gut	NOUN
aji-177	209	5	barrier	barrier	NOUN
aji-177	209	6	reduces	reduce	VERB
aji-177	209	7	systemic	systemic	ADJ
aji-177	209	8	inflammatory	inflammatory	ADJ
aji-177	209	9	tone	tone	NOUN
aji-177	209	10	.	.	PUNCT
aji-177	210	1	secondary	secondary	ADJ
aji-177	210	2	bile	bile	NOUN
aji-177	210	3	acids	acid	NOUN
aji-177	210	4	context	context	NOUN
aji-177	210	5	-	-	PUNCT
aji-177	210	6	dependent	dependent	ADJ
aji-177	210	7	(	(	PUNCT
aji-177	210	8	often	often	ADV
aji-177	210	9	promotive	promotive	ADJ
aji-177	210	10	in	in	ADP
aji-177	210	11	dysbiosis	dysbiosis	NOUN
aji-177	210	12	mitochondrial	mitochondrial	ADJ
aji-177	210	13	stress	stress	NOUN
aji-177	210	14	:	:	PUNCT
aji-177	210	15	high	high	ADJ
aji-177	210	16	concentrations	concentration	NOUN
aji-177	210	17	of	of	ADP
aji-177	210	18	dca	dca	PROPN
aji-177	210	19	act	act	PROPN
aji-177	210	20	as	as	ADP
aji-177	210	21	detergents	detergent	NOUN
aji-177	210	22	,	,	PUNCT
aji-177	210	23	disrupting	disrupt	VERB
aji-177	210	24	mitochondrial	mitochondrial	ADJ
aji-177	210	25	membranes	membrane	NOUN
aji-177	210	26	and	and	CCONJ
aji-177	210	27	inducing	induce	VERB
aji-177	210	28	mitochondrial	mitochondrial	ADJ
aji-177	210	29	ros	ro	NOUN
aji-177	210	30	(	(	PUNCT
aji-177	210	31	mtros	mtro	NOUN
aji-177	210	32	)	)	PUNCT
aji-177	210	33	,	,	PUNCT
aji-177	210	34	which	which	PRON
aji-177	210	35	drives	drive	VERB
aji-177	210	36	netosis	netosis	PRON
aji-177	210	37	(	(	PUNCT
aji-177	210	38	zhao	zhao	PROPN
aji-177	210	39	et	et	PROPN
aji-177	210	40	al	al	PROPN
aji-177	210	41	.	.	PROPN
aji-177	210	42	,	,	PUNCT
aji-177	210	43	2025	2025	NUM
aji-177	210	44	)	)	PUNCT
aji-177	210	45	.	.	PUNCT
aji-177	211	1	nlrp3	nlrp3	PROPN
aji-177	211	2	inflammasome	inflammasome	NOUN
aji-177	211	3	activation	activation	NOUN
aji-177	211	4	:	:	PUNCT
aji-177	211	5	can	can	AUX
aji-177	211	6	prime	prime	VERB
aji-177	211	7	and	and	CCONJ
aji-177	211	8	activate	activate	VERB
aji-177	211	9	the	the	DET
aji-177	211	10	inflammasome	inflammasome	NOUN
aji-177	211	11	in	in	ADP
aji-177	211	12	immune	immune	ADJ
aji-177	211	13	cells	cell	NOUN
aji-177	211	14	,	,	PUNCT
aji-177	211	15	leading	lead	VERB
aji-177	211	16	to	to	ADP
aji-177	211	17	il-1β	il-1β	PROPN
aji-177	211	18	release	release	PROPN
aji-177	211	19	,	,	PUNCT
aji-177	211	20	a	a	DET
aji-177	211	21	potent	potent	ADJ
aji-177	211	22	netosis	netosis	NOUN
aji-177	211	23	trigger	trigger	NOUN
aji-177	211	24	.	.	PUNCT
aji-177	212	1	certain	certain	ADJ
aji-177	212	2	bas	bas	PROPN
aji-177	212	3	can	can	AUX
aji-177	212	4	have	have	VERB
aji-177	212	5	anti	anti	ADJ
aji-177	212	6	-	-	ADJ
aji-177	212	7	inflammatory	inflammatory	ADJ
aji-177	212	8	effects	effect	NOUN
aji-177	212	9	.	.	PUNCT
aji-177	213	1	an	an	DET
aji-177	213	2	imbalanced	imbalanced	ADJ
aji-177	213	3	ratio	ratio	NOUN
aji-177	213	4	of	of	ADP
aji-177	213	5	proto	proto	PROPN
aji-177	213	6	antiinflammatory	antiinflammatory	NOUN
aji-177	213	7	bas	bas	PROPN
aji-177	213	8	creates	create	VERB
aji-177	213	9	a	a	DET
aji-177	213	10	systemic	systemic	ADJ
aji-177	213	11	environment	environment	NOUN
aji-177	213	12	that	that	PRON
aji-177	213	13	favors	favor	VERB
aji-177	213	14	neutrophil	neutrophil	ADJ
aji-177	213	15	activation	activation	NOUN
aji-177	213	16	.	.	PUNCT
aji-177	214	1	jimoh	jimoh	PROPN
aji-177	214	2	et	et	PROPN
aji-177	214	3	al	al	PROPN
aji-177	214	4	.	.	PROPN
aji-177	214	5	;	;	PUNCT
aji-177	214	6	asian	asian	PROPN
aji-177	214	7	j.	j.	PROPN
aji-177	214	8	immunol	immunol	PROPN
aji-177	214	9	.	.	PROPN
aji-177	214	10	,	,	PUNCT
aji-177	214	11	vol	vol	NOUN
aji-177	214	12	.	.	PROPN
aji-177	214	13	8	8	NUM
aji-177	214	14	,	,	PUNCT
aji-177	214	15	no	no	INTJ
aji-177	214	16	.	.	NOUN
aji-177	214	17	1	1	NUM
aji-177	214	18	,	,	PUNCT
aji-177	214	19	pp	pp	ADJ
aji-177	214	20	.	.	PUNCT
aji-177	215	1	257	257	NUM
aji-177	215	2	-	-	SYM
aji-177	215	3	268	268	NUM
aji-177	215	4	,	,	PUNCT
aji-177	215	5	2025	2025	NUM
aji-177	215	6	;	;	PUNCT
aji-177	215	7	article	article	NOUN
aji-177	215	8	no.aji.147982	no.aji.147982	VERB
aji-177	215	9	263	263	NUM
aji-177	215	10	polyamines	polyamine	NOUN
aji-177	215	11	:	:	PUNCT
aji-177	215	12	spermidine	spermidine	NOUN
aji-177	215	13	emerges	emerge	VERB
aji-177	215	14	as	as	ADP
aji-177	215	15	a	a	DET
aji-177	215	16	powerful	powerful	ADJ
aji-177	215	17	,	,	PUNCT
aji-177	215	18	direct	direct	ADJ
aji-177	215	19	inhibitor	inhibitor	NOUN
aji-177	215	20	of	of	ADP
aji-177	215	21	netosis	netosis	NOUN
aji-177	215	22	.	.	PUNCT
aji-177	216	1	it	it	PRON
aji-177	216	2	exerts	exert	VERB
aji-177	216	3	its	its	PRON
aji-177	216	4	effect	effect	NOUN
aji-177	216	5	by	by	ADP
aji-177	216	6	targeting	target	VERB
aji-177	216	7	two	two	NUM
aji-177	216	8	key	key	ADJ
aji-177	216	9	nodes	node	NOUN
aji-177	216	10	in	in	ADP
aji-177	216	11	the	the	DET
aji-177	216	12	process	process	NOUN
aji-177	216	13	.	.	PUNCT
aji-177	217	1	first	first	ADV
aji-177	217	2	,	,	PUNCT
aji-177	217	3	it	it	PRON
aji-177	217	4	directly	directly	ADV
aji-177	217	5	inhibits	inhibit	VERB
aji-177	217	6	pad4	pad4	NOUN
aji-177	217	7	enzymatic	enzymatic	ADJ
aji-177	217	8	activity	activity	NOUN
aji-177	217	9	,	,	PUNCT
aji-177	217	10	preventing	prevent	VERB
aji-177	217	11	the	the	DET
aji-177	217	12	initiation	initiation	NOUN
aji-177	217	13	of	of	ADP
aji-177	217	14	chromatin	chromatin	NOUN
aji-177	217	15	decondensation	decondensation	NOUN
aji-177	217	16	(	(	PUNCT
aji-177	217	17	perrone	perrone	NOUN
aji-177	217	18	and	and	CCONJ
aji-177	217	19	d'angelo	d'angelo	PROPN
aji-177	217	20	,	,	PUNCT
aji-177	217	21	2025	2025	NUM
aji-177	217	22	)	)	PUNCT
aji-177	217	23	.	.	PUNCT
aji-177	218	1	second	second	ADJ
aji-177	218	2	,	,	PUNCT
aji-177	218	3	it	it	PRON
aji-177	218	4	suppresses	suppress	VERB
aji-177	218	5	the	the	DET
aji-177	218	6	generation	generation	NOUN
aji-177	218	7	of	of	ADP
aji-177	218	8	ros	ros	PROPN
aji-177	218	9	by	by	ADP
aji-177	218	10	the	the	DET
aji-177	218	11	nadph	nadph	ADJ
aji-177	218	12	oxidase	oxidase	NOUN
aji-177	218	13	complex	complex	NOUN
aji-177	218	14	.	.	PUNCT
aji-177	219	1	additionally	additionally	ADV
aji-177	219	2	,	,	PUNCT
aji-177	219	3	its	its	PRON
aji-177	219	4	well	well	ADV
aji-177	219	5	-	-	PUNCT
aji-177	219	6	established	establish	VERB
aji-177	219	7	role	role	NOUN
aji-177	219	8	as	as	ADP
aji-177	219	9	an	an	DET
aji-177	219	10	inducer	inducer	NOUN
aji-177	219	11	of	of	ADP
aji-177	219	12	autophagy	autophagy	NOUN
aji-177	219	13	(	(	PUNCT
aji-177	219	14	saha	saha	NOUN
aji-177	219	15	and	and	CCONJ
aji-177	219	16	goswami	goswami	PROPN
aji-177	219	17	,	,	PUNCT
aji-177	219	18	2025	2025	NUM
aji-177	219	19	,	,	PUNCT
aji-177	219	20	lu	lu	PROPN
aji-177	219	21	et	et	PROPN
aji-177	219	22	al	al	PROPN
aji-177	219	23	.	.	PROPN
aji-177	219	24	,	,	PUNCT
aji-177	219	25	2024	2024	NUM
aji-177	219	26	)	)	PUNCT
aji-177	219	27	helps	help	VERB
aji-177	219	28	maintain	maintain	VERB
aji-177	219	29	cellular	cellular	ADJ
aji-177	219	30	homeostasis	homeostasis	NOUN
aji-177	219	31	in	in	ADP
aji-177	219	32	neutrophils	neutrophil	NOUN
aji-177	219	33	by	by	ADP
aji-177	219	34	clearing	clear	VERB
aji-177	219	35	damaged	damage	VERB
aji-177	219	36	organelles	organelle	NOUN
aji-177	219	37	that	that	PRON
aji-177	219	38	could	could	AUX
aji-177	219	39	otherwise	otherwise	ADV
aji-177	219	40	serve	serve	VERB
aji-177	219	41	as	as	ADP
aji-177	219	42	intrinsic	intrinsic	ADJ
aji-177	219	43	inducers	inducer	NOUN
aji-177	219	44	of	of	ADP
aji-177	219	45	netosis	netosis	NOUN
aji-177	219	46	.	.	PUNCT
aji-177	220	1	3.2	3.2	NUM
aji-177	220	2	inductive	inductive	ADJ
aji-177	220	3	metabolites	metabolite	NOUN
aji-177	220	4	:	:	PUNCT
aji-177	220	5	the	the	DET
aji-177	220	6	detrimental	detrimental	ADJ
aji-177	220	7	role	role	NOUN
aji-177	220	8	of	of	ADP
aji-177	220	9	dysbiosis	dysbiosis	NOUN
aji-177	220	10	secondary	secondary	ADJ
aji-177	220	11	bile	bile	NOUN
aji-177	220	12	acids	acid	NOUN
aji-177	220	13	:	:	PUNCT
aji-177	220	14	in	in	ADP
aji-177	220	15	a	a	DET
aji-177	220	16	state	state	NOUN
aji-177	220	17	of	of	ADP
aji-177	220	18	dysbiosis	dysbiosis	NOUN
aji-177	220	19	,	,	PUNCT
aji-177	220	20	an	an	DET
aji-177	220	21	overabundance	overabundance	NOUN
aji-177	220	22	of	of	ADP
aji-177	220	23	certain	certain	ADJ
aji-177	220	24	secondary	secondary	ADJ
aji-177	220	25	bile	bile	NOUN
aji-177	220	26	acids	acid	NOUN
aji-177	220	27	like	like	ADP
aji-177	220	28	deoxycholic	deoxycholic	PROPN
aji-177	220	29	acid	acid	PROPN
aji-177	220	30	(	(	PUNCT
aji-177	220	31	dca	dca	PROPN
aji-177	220	32	)	)	PUNCT
aji-177	220	33	can	can	AUX
aji-177	220	34	have	have	VERB
aji-177	220	35	the	the	DET
aji-177	220	36	opposite	opposite	ADJ
aji-177	220	37	effect	effect	NOUN
aji-177	220	38	.	.	PUNCT
aji-177	221	1	at	at	ADP
aji-177	221	2	high	high	ADJ
aji-177	221	3	concentrations	concentration	NOUN
aji-177	221	4	,	,	PUNCT
aji-177	221	5	dca	dca	PROPN
aji-177	221	6	can	can	AUX
aji-177	221	7	disrupt	disrupt	VERB
aji-177	221	8	mitochondrial	mitochondrial	ADJ
aji-177	221	9	membranes	membrane	NOUN
aji-177	221	10	in	in	ADP
aji-177	221	11	neutrophils	neutrophil	NOUN
aji-177	221	12	,	,	PUNCT
aji-177	221	13	leading	lead	VERB
aji-177	221	14	to	to	ADP
aji-177	221	15	the	the	DET
aji-177	221	16	leakage	leakage	NOUN
aji-177	221	17	of	of	ADP
aji-177	221	18	mitochondrial	mitochondrial	ADJ
aji-177	221	19	dna	dna	NOUN
aji-177	221	20	and	and	CCONJ
aji-177	221	21	the	the	DET
aji-177	221	22	generation	generation	NOUN
aji-177	221	23	of	of	ADP
aji-177	221	24	mitochondrial	mitochondrial	ADJ
aji-177	221	25	ros	ros	PROPN
aji-177	221	26	(	(	PUNCT
aji-177	221	27	mtros	mtro	NOUN
aji-177	221	28	)	)	PUNCT
aji-177	221	29	.	.	PUNCT
aji-177	222	1	this	this	DET
aji-177	222	2	mtros	mtro	NOUN
aji-177	222	3	can	can	AUX
aji-177	222	4	act	act	VERB
aji-177	222	5	as	as	ADP
aji-177	222	6	a	a	DET
aji-177	222	7	potent	potent	ADJ
aji-177	222	8	trigger	trigger	NOUN
aji-177	222	9	for	for	ADP
aji-177	222	10	netosis	netosis	NOUN
aji-177	222	11	,	,	PUNCT
aji-177	222	12	independent	independent	ADJ
aji-177	222	13	of	of	ADP
aji-177	222	14	or	or	CCONJ
aji-177	222	15	synergistic	synergistic	ADJ
aji-177	222	16	with	with	ADP
aji-177	222	17	the	the	DET
aji-177	222	18	nadph	nadph	ADJ
aji-177	222	19	oxidase	oxidase	NOUN
aji-177	222	20	pathway	pathway	NOUN
aji-177	222	21	(	(	PUNCT
aji-177	222	22	saha	saha	PROPN
aji-177	222	23	and	and	CCONJ
aji-177	222	24	goswami	goswami	PROPN
aji-177	222	25	,	,	PUNCT
aji-177	222	26	2025	2025	NUM
aji-177	222	27	)	)	PUNCT
aji-177	222	28	.	.	PUNCT
aji-177	223	1	this	this	DET
aji-177	223	2	highlights	highlight	NOUN
aji-177	223	3	that	that	SCONJ
aji-177	223	4	the	the	DET
aji-177	223	5	impact	impact	NOUN
aji-177	223	6	of	of	ADP
aji-177	223	7	microbial	microbial	ADJ
aji-177	223	8	metabolites	metabolite	NOUN
aji-177	223	9	is	be	AUX
aji-177	223	10	not	not	PART
aji-177	223	11	universally	universally	ADV
aji-177	223	12	beneficial	beneficial	ADJ
aji-177	223	13	and	and	CCONJ
aji-177	223	14	is	be	AUX
aji-177	223	15	entirely	entirely	ADV
aji-177	223	16	dependent	dependent	ADJ
aji-177	223	17	on	on	ADP
aji-177	223	18	the	the	DET
aji-177	223	19	compositional	compositional	ADJ
aji-177	223	20	and	and	CCONJ
aji-177	223	21	metabolic	metabolic	NOUN
aji-177	223	22	balance	balance	NOUN
aji-177	223	23	of	of	ADP
aji-177	223	24	the	the	DET
aji-177	223	25	gut	gut	NOUN
aji-177	223	26	community	community	NOUN
aji-177	223	27	.	.	PUNCT
aji-177	224	1	3.3	3.3	NUM
aji-177	224	2	indirect	indirect	ADJ
aji-177	224	3	modulation	modulation	NOUN
aji-177	224	4	via	via	ADP
aji-177	224	5	the	the	DET
aji-177	224	6	tumor	tumor	NOUN
aji-177	224	7	microenvironment	microenvironment	NOUN
aji-177	224	8	beyond	beyond	ADP
aji-177	224	9	direct	direct	ADJ
aji-177	224	10	actions	action	NOUN
aji-177	224	11	on	on	ADP
aji-177	224	12	neutrophils	neutrophil	NOUN
aji-177	224	13	,	,	PUNCT
aji-177	224	14	microbial	microbial	ADJ
aji-177	224	15	metabolites	metabolite	NOUN
aji-177	224	16	sculpt	sculpt	VERB
aji-177	224	17	the	the	DET
aji-177	224	18	broader	broad	ADJ
aji-177	224	19	tme	tme	NOUN
aji-177	224	20	,	,	PUNCT
aji-177	224	21	creating	create	VERB
aji-177	224	22	feedback	feedback	NOUN
aji-177	224	23	loops	loop	NOUN
aji-177	224	24	that	that	PRON
aji-177	224	25	influence	influence	NOUN
aji-177	224	26	netosis	netosis	ADV
aji-177	224	27	.	.	PUNCT
aji-177	225	1	for	for	ADP
aji-177	225	2	instance	instance	NOUN
aji-177	225	3	,	,	PUNCT
aji-177	225	4	scfas	scfas	NOUN
aji-177	225	5	and	and	CCONJ
aji-177	225	6	inosine	inosine	NOUN
aji-177	225	7	promote	promote	VERB
aji-177	225	8	the	the	DET
aji-177	225	9	activation	activation	NOUN
aji-177	225	10	and	and	CCONJ
aji-177	225	11	tumor	tumor	NOUN
aji-177	225	12	infiltration	infiltration	NOUN
aji-177	225	13	of	of	ADP
aji-177	225	14	cd8	cd8	PROPN
aji-177	225	15	+	+	PROPN
aji-177	225	16	t	t	PROPN
aji-177	225	17	cells	cell	NOUN
aji-177	225	18	and	and	CCONJ
aji-177	225	19	th1	th1	NOUN
aji-177	225	20	cells	cell	NOUN
aji-177	225	21	(	(	PUNCT
aji-177	225	22	zhao	zhao	PROPN
aji-177	225	23	et	et	PROPN
aji-177	225	24	al	al	PROPN
aji-177	225	25	.	.	PROPN
aji-177	225	26	,	,	PUNCT
aji-177	225	27	2025	2025	NUM
aji-177	225	28	)	)	PUNCT
aji-177	225	29	.	.	PUNCT
aji-177	226	1	these	these	DET
aji-177	226	2	activated	activate	VERB
aji-177	226	3	t	t	NOUN
aji-177	226	4	cells	cell	NOUN
aji-177	226	5	produce	produce	VERB
aji-177	226	6	ifn	ifn	PROPN
aji-177	226	7	-	-	PUNCT
aji-177	226	8	γ	γ	NOUN
aji-177	226	9	,	,	PUNCT
aji-177	226	10	which	which	PRON
aji-177	226	11	can	can	AUX
aji-177	226	12	have	have	VERB
aji-177	226	13	complex	complex	ADJ
aji-177	226	14	effects	effect	NOUN
aji-177	226	15	on	on	ADP
aji-177	226	16	neutrophils	neutrophil	NOUN
aji-177	226	17	but	but	CCONJ
aji-177	226	18	can	can	AUX
aji-177	226	19	also	also	ADV
aji-177	226	20	contribute	contribute	VERB
aji-177	226	21	to	to	ADP
aji-177	226	22	an	an	DET
aji-177	226	23	anti	anti	ADJ
aji-177	226	24	-	-	ADJ
aji-177	226	25	tumor	tumor	ADJ
aji-177	226	26	immune	immune	ADJ
aji-177	226	27	cycle	cycle	NOUN
aji-177	226	28	that	that	PRON
aji-177	226	29	suppresses	suppress	VERB
aji-177	226	30	the	the	DET
aji-177	226	31	pro	pro	ADJ
aji-177	226	32	-	-	ADJ
aji-177	226	33	tumorigenic	tumorigenic	ADJ
aji-177	226	34	functions	function	NOUN
aji-177	226	35	of	of	ADP
aji-177	226	36	neutrophils	neutrophil	NOUN
aji-177	226	37	,	,	PUNCT
aji-177	226	38	including	include	VERB
aji-177	226	39	excessive	excessive	ADJ
aji-177	226	40	net	net	ADJ
aji-177	226	41	formation	formation	NOUN
aji-177	226	42	.	.	PUNCT
aji-177	227	1	conversely	conversely	ADV
aji-177	227	2	,	,	PUNCT
aji-177	227	3	a	a	DET
aji-177	227	4	metabolite	metabolite	NOUN
aji-177	227	5	profile	profile	NOUN
aji-177	227	6	that	that	PRON
aji-177	227	7	favors	favor	VERB
aji-177	227	8	treg	treg	PROPN
aji-177	227	9	expansion	expansion	PROPN
aji-177	227	10	and	and	CCONJ
aji-177	227	11	m2	m2	PROPN
aji-177	227	12	macrophage	macrophage	ADJ
aji-177	227	13	polarization	polarization	NOUN
aji-177	227	14	can	can	AUX
aji-177	227	15	create	create	VERB
aji-177	227	16	an	an	DET
aji-177	227	17	immunosuppressive	immunosuppressive	ADJ
aji-177	227	18	environment	environment	NOUN
aji-177	227	19	that	that	PRON
aji-177	227	20	indirectly	indirectly	ADV
aji-177	227	21	permits	permit	VERB
aji-177	227	22	sustained	sustain	VERB
aji-177	227	23	netosis	netosis	NOUN
aji-177	227	24	.	.	PUNCT
aji-177	228	1	gut	gut	VERB
aji-177	228	2	microbial	microbial	ADJ
aji-177	228	3	metabolites	metabolite	NOUN
aji-177	228	4	function	function	NOUN
aji-177	228	5	as	as	ADP
aji-177	228	6	master	master	NOUN
aji-177	228	7	regulators	regulator	NOUN
aji-177	228	8	of	of	ADP
aji-177	228	9	netosis	netosis	NOUN
aji-177	228	10	through	through	ADP
aji-177	228	11	a	a	DET
aji-177	228	12	multi	multi	ADJ
aji-177	228	13	-	-	ADJ
aji-177	228	14	pronged	pronged	ADJ
aji-177	228	15	strategy	strategy	NOUN
aji-177	228	16	involving	involve	VERB
aji-177	228	17	direct	direct	ADJ
aji-177	228	18	epigenetic	epigenetic	ADJ
aji-177	228	19	and	and	CCONJ
aji-177	228	20	enzymatic	enzymatic	ADJ
aji-177	228	21	interference	interference	NOUN
aji-177	228	22	,	,	PUNCT
aji-177	228	23	receptor	receptor	NOUN
aji-177	228	24	-	-	PUNCT
aji-177	228	25	mediated	mediate	VERB
aji-177	228	26	signaling	signaling	NOUN
aji-177	228	27	,	,	PUNCT
aji-177	228	28	and	and	CCONJ
aji-177	228	29	systemic	systemic	ADJ
aji-177	228	30	modulation	modulation	NOUN
aji-177	228	31	of	of	ADP
aji-177	228	32	inflammatory	inflammatory	ADJ
aji-177	228	33	tone	tone	NOUN
aji-177	228	34	.	.	PUNCT
aji-177	229	1	a	a	DET
aji-177	229	2	favorable	favorable	ADJ
aji-177	229	3	microbiome	microbiome	NOUN
aji-177	229	4	generates	generate	VERB
aji-177	229	5	a	a	DET
aji-177	229	6	metabolite	metabolite	NOUN
aji-177	229	7	profile	profile	NOUN
aji-177	229	8	that	that	PRON
aji-177	229	9	acts	act	VERB
aji-177	229	10	as	as	ADP
aji-177	229	11	a	a	DET
aji-177	229	12	"	"	PUNCT
aji-177	229	13	brake	brake	NOUN
aji-177	229	14	"	"	PUNCT
aji-177	229	15	on	on	ADP
aji-177	229	16	pathological	pathological	ADJ
aji-177	229	17	netosis	netosis	NOUN
aji-177	229	18	,	,	PUNCT
aji-177	229	19	while	while	SCONJ
aji-177	229	20	a	a	DET
aji-177	229	21	dysbiotic	dysbiotic	ADJ
aji-177	229	22	microbiome	microbiome	NOUN
aji-177	229	23	often	often	ADV
aji-177	229	24	releases	release	VERB
aji-177	229	25	the	the	DET
aji-177	229	26	"	"	PUNCT
aji-177	229	27	accelerator	accelerator	NOUN
aji-177	229	28	,	,	PUNCT
aji-177	229	29	"	"	PUNCT
aji-177	229	30	contributing	contribute	VERB
aji-177	229	31	to	to	ADP
aji-177	229	32	an	an	DET
aji-177	229	33	icb	icb	NOUN
aji-177	229	34	-	-	PUNCT
aji-177	229	35	resistant	resistant	ADJ
aji-177	229	36	tme	tme	X
aji-177	229	37	(	(	PUNCT
aji-177	229	38	saha	saha	PROPN
aji-177	229	39	and	and	CCONJ
aji-177	229	40	goswami	goswami	PROPN
aji-177	229	41	,	,	PUNCT
aji-177	229	42	2025	2025	NUM
aji-177	229	43	,	,	PUNCT
aji-177	229	44	korbecki	korbecki	PROPN
aji-177	229	45	et	et	PROPN
aji-177	229	46	al	al	PROPN
aji-177	229	47	.	.	PROPN
aji-177	229	48	,	,	PUNCT
aji-177	229	49	2025	2025	NUM
aji-177	229	50	)	)	PUNCT
aji-177	229	51	.	.	PUNCT
aji-177	230	1	4	4	X
aji-177	230	2	.	.	X
aji-177	230	3	the	the	DET
aji-177	230	4	gut	gut	NOUN
aji-177	230	5	-	-	PUNCT
aji-177	230	6	net	net	NOUN
aji-177	230	7	-	-	PUNCT
aji-177	230	8	icb	icb	NOUN
aji-177	230	9	axis	axis	NOUN
aji-177	230	10	:	:	PUNCT
aji-177	230	11	an	an	DET
aji-177	230	12	integrated	integrated	ADJ
aji-177	230	13	model	model	NOUN
aji-177	230	14	we	we	PRON
aji-177	230	15	propose	propose	VERB
aji-177	230	16	a	a	DET
aji-177	230	17	comprehensive	comprehensive	ADJ
aji-177	230	18	model	model	NOUN
aji-177	230	19	wherein	wherein	SCONJ
aji-177	230	20	the	the	DET
aji-177	230	21	gut	gut	NOUN
aji-177	230	22	microbiome	microbiome	NOUN
aji-177	230	23	dictates	dictate	VERB
aji-177	230	24	clinical	clinical	ADJ
aji-177	230	25	response	response	NOUN
aji-177	230	26	to	to	ADP
aji-177	230	27	immune	immune	ADJ
aji-177	230	28	checkpoint	checkpoint	NOUN
aji-177	230	29	blockade	blockade	NOUN
aji-177	230	30	(	(	PUNCT
aji-177	230	31	icb	icb	PROPN
aji-177	230	32	)	)	PUNCT
aji-177	230	33	through	through	ADP
aji-177	230	34	the	the	DET
aji-177	230	35	systemic	systemic	ADJ
aji-177	230	36	regulation	regulation	NOUN
aji-177	230	37	of	of	ADP
aji-177	230	38	neutrophil	neutrophil	ADJ
aji-177	230	39	extracellular	extracellular	ADJ
aji-177	230	40	trap	trap	NOUN
aji-177	230	41	(	(	PUNCT
aji-177	230	42	net	net	ADJ
aji-177	230	43	)	)	PUNCT
aji-177	230	44	formation	formation	NOUN
aji-177	230	45	,	,	PUNCT
aji-177	230	46	with	with	ADP
aji-177	230	47	microbial	microbial	ADJ
aji-177	230	48	metabolites	metabolite	NOUN
aji-177	230	49	serving	serve	VERB
aji-177	230	50	as	as	ADP
aji-177	230	51	the	the	DET
aji-177	230	52	primary	primary	ADJ
aji-177	230	53	signaling	signal	VERB
aji-177	230	54	intermediaries	intermediary	NOUN
aji-177	230	55	.	.	PUNCT
aji-177	231	1	this	this	DET
aji-177	231	2	"	"	PUNCT
aji-177	231	3	gut	gut	NOUN
aji-177	231	4	-	-	PUNCT
aji-177	231	5	net	net	NOUN
aji-177	231	6	-	-	PUNCT
aji-177	231	7	icb	icb	PROPN
aji-177	231	8	axis	axis	NOUN
aji-177	231	9	"	"	PUNCT
aji-177	231	10	provides	provide	VERB
aji-177	231	11	a	a	DET
aji-177	231	12	mechanistic	mechanistic	ADJ
aji-177	231	13	framework	framework	NOUN
aji-177	231	14	to	to	PART
aji-177	231	15	explain	explain	VERB
aji-177	231	16	how	how	SCONJ
aji-177	231	17	the	the	DET
aji-177	231	18	intestinal	intestinal	ADJ
aji-177	231	19	microbiota	microbiota	NOUN
aji-177	231	20	can	can	AUX
aji-177	231	21	influence	influence	VERB
aji-177	231	22	anti	anti	ADJ
aji-177	231	23	-	-	ADJ
aji-177	231	24	tumor	tumor	ADJ
aji-177	231	25	immunity	immunity	NOUN
aji-177	231	26	in	in	ADP
aji-177	231	27	distant	distant	ADJ
aji-177	231	28	tissues	tissue	NOUN
aji-177	231	29	.	.	PUNCT
aji-177	232	1	the	the	DET
aji-177	232	2	model	model	NOUN
aji-177	232	3	pivots	pivot	NOUN
aji-177	232	4	on	on	ADP
aji-177	232	5	the	the	DET
aji-177	232	6	balance	balance	NOUN
aji-177	232	7	between	between	ADP
aji-177	232	8	two	two	NUM
aji-177	232	9	contrasting	contrast	VERB
aji-177	232	10	states	state	NOUN
aji-177	232	11	:	:	PUNCT
aji-177	232	12	a	a	DET
aji-177	232	13	netosissuppressive	netosissuppressive	ADJ
aji-177	232	14	,	,	PUNCT
aji-177	232	15	icb	icb	PROPN
aji-177	232	16	-	-	PUNCT
aji-177	232	17	permissive	permissive	ADJ
aji-177	232	18	state	state	NOUN
aji-177	232	19	and	and	CCONJ
aji-177	232	20	a	a	DET
aji-177	232	21	netosis	netosis	NOUN
aji-177	232	22	-	-	PUNCT
aji-177	232	23	promotive	promotive	ADJ
aji-177	232	24	,	,	PUNCT
aji-177	232	25	icb	icb	NOUN
aji-177	232	26	-	-	PUNCT
aji-177	232	27	resistant	resistant	ADJ
aji-177	232	28	state	state	NOUN
aji-177	232	29	.	.	PUNCT
aji-177	233	1	the	the	DET
aji-177	233	2	following	follow	VERB
aji-177	233	3	table	table	NOUN
aji-177	233	4	outlines	outline	VERB
aji-177	233	5	the	the	DET
aji-177	233	6	contrasting	contrast	VERB
aji-177	233	7	characteristics	characteristic	NOUN
aji-177	233	8	of	of	ADP
aji-177	233	9	these	these	DET
aji-177	233	10	two	two	NUM
aji-177	233	11	states	state	NOUN
aji-177	233	12	within	within	ADP
aji-177	233	13	our	our	PRON
aji-177	233	14	integrated	integrated	ADJ
aji-177	233	15	model	model	NOUN
aji-177	233	16	.	.	PUNCT
aji-177	234	1	4.1	4.1	NUM
aji-177	234	2	the	the	DET
aji-177	234	3	icb	icb	PROPN
aji-177	234	4	-	-	PUNCT
aji-177	234	5	permissive	permissive	ADJ
aji-177	234	6	cycle	cycle	NOUN
aji-177	234	7	:	:	PUNCT
aji-177	234	8	a	a	DET
aji-177	234	9	favorable	favorable	ADJ
aji-177	234	10	microbiome	microbiome	NOUN
aji-177	234	11	suppresses	suppress	VERB
aji-177	234	12	nets	net	NOUN
aji-177	234	13	in	in	ADP
aji-177	234	14	this	this	DET
aji-177	234	15	virtuous	virtuous	ADJ
aji-177	234	16	cycle	cycle	NOUN
aji-177	234	17	,	,	PUNCT
aji-177	234	18	a	a	DET
aji-177	234	19	diverse	diverse	ADJ
aji-177	234	20	and	and	CCONJ
aji-177	234	21	balanced	balanced	ADJ
aji-177	234	22	gut	gut	NOUN
aji-177	234	23	microbiome	microbiome	NOUN
aji-177	234	24	,	,	PUNCT
aji-177	234	25	characterized	characterize	VERB
aji-177	234	26	by	by	ADP
aji-177	234	27	taxa	taxa	NOUN
aji-177	234	28	such	such	ADJ
aji-177	234	29	as	as	ADP
aji-177	234	30	akkermansia	akkermansia	PROPN
aji-177	234	31	muciniphila	muciniphila	NOUN
aji-177	234	32	,	,	PUNCT
aji-177	234	33	faecalibacterium	faecalibacterium	NOUN
aji-177	234	34	prausnitzii	prausnitzii	NOUN
aji-177	234	35	,	,	PUNCT
aji-177	234	36	and	and	CCONJ
aji-177	234	37	bifidobacterium	bifidobacterium	NOUN
aji-177	234	38	spp	spp	NOUN
aji-177	234	39	.	.	PROPN
aji-177	234	40	,	,	PUNCT
aji-177	234	41	generates	generate	VERB
aji-177	234	42	a	a	DET
aji-177	234	43	metabolite	metabolite	NOUN
aji-177	234	44	profile	profile	NOUN
aji-177	234	45	rich	rich	ADJ
aji-177	234	46	in	in	ADP
aji-177	234	47	scfas	scfas	NOUN
aji-177	234	48	,	,	PUNCT
aji-177	234	49	polyamines	polyamine	NOUN
aji-177	234	50	,	,	PUNCT
aji-177	234	51	and	and	CCONJ
aji-177	234	52	ahr	ahr	PROPN
aji-177	234	53	ligands	ligand	NOUN
aji-177	234	54	.	.	PUNCT
aji-177	235	1	metabolite	metabolite	NOUN
aji-177	235	2	production	production	NOUN
aji-177	235	3	:	:	PUNCT
aji-177	235	4	these	these	DET
aji-177	235	5	microbes	microbe	NOUN
aji-177	235	6	ferment	ferment	VERB
aji-177	235	7	dietary	dietary	ADJ
aji-177	235	8	fiber	fiber	NOUN
aji-177	235	9	to	to	PART
aji-177	235	10	produce	produce	VERB
aji-177	235	11	high	high	ADJ
aji-177	235	12	levels	level	NOUN
aji-177	235	13	of	of	ADP
aji-177	235	14	butyrate	butyrate	NOUN
aji-177	235	15	and	and	CCONJ
aji-177	235	16	other	other	ADJ
aji-177	235	17	scfas	scfas	NOUN
aji-177	235	18	.	.	PUNCT
aji-177	236	1	they	they	PRON
aji-177	236	2	also	also	ADV
aji-177	236	3	generate	generate	VERB
aji-177	236	4	immunomodulatory	immunomodulatory	ADJ
aji-177	236	5	polyamines	polyamine	NOUN
aji-177	236	6	like	like	ADP
aji-177	236	7	spermidine	spermidine	NOUN
aji-177	236	8	and	and	CCONJ
aji-177	236	9	tryptophan	tryptophan	NOUN
aji-177	236	10	-	-	PUNCT
aji-177	236	11	derived	derive	VERB
aji-177	236	12	ahr	ahr	NOUN
aji-177	236	13	ligands	ligand	NOUN
aji-177	236	14	.	.	PUNCT
aji-177	237	1	systemic	systemic	ADJ
aji-177	237	2	signaling	signaling	NOUN
aji-177	237	3	:	:	PUNCT
aji-177	237	4	these	these	DET
aji-177	237	5	metabolites	metabolite	NOUN
aji-177	237	6	are	be	AUX
aji-177	237	7	absorbed	absorb	VERB
aji-177	237	8	into	into	ADP
aji-177	237	9	the	the	DET
aji-177	237	10	portal	portal	ADJ
aji-177	237	11	circulation	circulation	NOUN
aji-177	237	12	and	and	CCONJ
aji-177	237	13	exert	exert	VERB
aji-177	237	14	systemic	systemic	ADJ
aji-177	237	15	effects	effect	NOUN
aji-177	237	16	.	.	PUNCT
aji-177	238	1	they	they	PRON
aji-177	238	2	reach	reach	VERB
aji-177	238	3	the	the	DET
aji-177	238	4	bone	bone	NOUN
aji-177	238	5	marrow	marrow	NOUN
aji-177	238	6	and	and	CCONJ
aji-177	238	7	the	the	DET
aji-177	238	8	tme	tme	NOUN
aji-177	238	9	,	,	PUNCT
aji-177	238	10	where	where	SCONJ
aji-177	238	11	they	they	PRON
aji-177	238	12	encounter	encounter	VERB
aji-177	238	13	neutrophils	neutrophil	NOUN
aji-177	238	14	.	.	PUNCT
aji-177	239	1	netosis	netosis	NOUN
aji-177	239	2	suppression	suppression	NOUN
aji-177	239	3	:	:	PUNCT
aji-177	239	4	as	as	SCONJ
aji-177	239	5	detailed	detailed	ADJ
aji-177	239	6	in	in	ADP
aji-177	239	7	section	section	NOUN
aji-177	239	8	4	4	NUM
aji-177	239	9	,	,	PUNCT
aji-177	239	10	these	these	DET
aji-177	239	11	metabolites	metabolite	NOUN
aji-177	239	12	directly	directly	ADV
aji-177	239	13	"	"	PUNCT
aji-177	239	14	raise	raise	VERB
aji-177	239	15	the	the	DET
aji-177	239	16	threshold	threshold	NOUN
aji-177	239	17	"	"	PUNCT
aji-177	239	18	for	for	ADP
aji-177	239	19	netosis	netosis	PROPN
aji-177	239	20	.	.	PUNCT
aji-177	240	1	butyrate	butyrate	PROPN
aji-177	240	2	(	(	PUNCT
aji-177	240	3	via	via	ADP
aji-177	240	4	hdaci	hdaci	NOUN
aji-177	240	5	)	)	PUNCT
aji-177	240	6	and	and	CCONJ
aji-177	240	7	spermidine	spermidine	NOUN
aji-177	240	8	(	(	PUNCT
aji-177	240	9	via	via	ADP
aji-177	240	10	pad4	pad4	NOUN
aji-177	240	11	inhibition	inhibition	NOUN
aji-177	240	12	)	)	PUNCT
aji-177	240	13	disrupt	disrupt	VERB
aji-177	240	14	the	the	DET
aji-177	240	15	core	core	ADJ
aji-177	240	16	biochemical	biochemical	ADJ
aji-177	240	17	pathways	pathway	NOUN
aji-177	240	18	required	require	VERB
aji-177	240	19	for	for	ADP
aji-177	240	20	chromatin	chromatin	NOUN
aji-177	240	21	decondensation	decondensation	NOUN
aji-177	240	22	and	and	CCONJ
aji-177	240	23	net	net	ADJ
aji-177	240	24	release	release	NOUN
aji-177	240	25	.	.	PUNCT
aji-177	241	1	jimoh	jimoh	PROPN
aji-177	241	2	et	et	PROPN
aji-177	241	3	al	al	PROPN
aji-177	241	4	.	.	PROPN
aji-177	241	5	;	;	PUNCT
aji-177	241	6	asian	asian	PROPN
aji-177	241	7	j.	j.	PROPN
aji-177	241	8	immunol	immunol	PROPN
aji-177	241	9	.	.	PROPN
aji-177	241	10	,	,	PUNCT
aji-177	241	11	vol	vol	NOUN
aji-177	241	12	.	.	PROPN
aji-177	241	13	8	8	NUM
aji-177	241	14	,	,	PUNCT
aji-177	241	15	no	no	INTJ
aji-177	241	16	.	.	NOUN
aji-177	241	17	1	1	NUM
aji-177	241	18	,	,	PUNCT
aji-177	241	19	pp	pp	ADJ
aji-177	241	20	.	.	PUNCT
aji-177	242	1	257	257	NUM
aji-177	242	2	-	-	SYM
aji-177	242	3	268	268	NUM
aji-177	242	4	,	,	PUNCT
aji-177	242	5	2025	2025	NUM
aji-177	242	6	;	;	PUNCT
aji-177	242	7	article	article	NOUN
aji-177	242	8	no.aji.147982	no.aji.147982	VERB
aji-177	242	9	264	264	NUM
aji-177	242	10	tme	tme	NOUN
aji-177	242	11	remodeling	remodeling	NOUN
aji-177	242	12	:	:	PUNCT
aji-177	242	13	the	the	DET
aji-177	242	14	consequent	consequent	ADJ
aji-177	242	15	low	low	ADJ
aji-177	242	16	level	level	NOUN
aji-177	242	17	of	of	ADP
aji-177	242	18	nets	net	NOUN
aji-177	242	19	in	in	ADP
aji-177	242	20	the	the	DET
aji-177	242	21	tme	tme	NOUN
aji-177	242	22	dismantles	dismantle	VERB
aji-177	242	23	a	a	DET
aji-177	242	24	major	major	ADJ
aji-177	242	25	immunosuppressive	immunosuppressive	ADJ
aji-177	242	26	barrier	barrier	NOUN
aji-177	242	27	.	.	PUNCT
aji-177	243	1	cd8	cd8	PROPN
aji-177	243	2	+	+	PROPN
aji-177	243	3	t	t	NOUN
aji-177	243	4	cells	cell	NOUN
aji-177	243	5	can	can	AUX
aji-177	243	6	effectively	effectively	ADV
aji-177	243	7	infiltrate	infiltrate	VERB
aji-177	243	8	the	the	DET
aji-177	243	9	tumor	tumor	NOUN
aji-177	243	10	parenchyma	parenchyma	NOUN
aji-177	243	11	,	,	PUNCT
aji-177	243	12	encounter	encounter	VERB
aji-177	243	13	their	their	PRON
aji-177	243	14	antigen	antigen	NOUN
aji-177	243	15	,	,	PUNCT
aji-177	243	16	and	and	CCONJ
aji-177	243	17	execute	execute	VERB
aji-177	243	18	cytotoxic	cytotoxic	ADJ
aji-177	243	19	functions	function	NOUN
aji-177	243	20	without	without	ADP
aji-177	243	21	being	be	AUX
aji-177	243	22	suppressed	suppress	VERB
aji-177	243	23	by	by	ADP
aji-177	243	24	netderived	netderive	VERB
aji-177	243	25	components	component	NOUN
aji-177	243	26	like	like	ADP
aji-177	243	27	histones	histone	NOUN
aji-177	243	28	and	and	CCONJ
aji-177	243	29	proteases	protease	NOUN
aji-177	243	30	.	.	PUNCT
aji-177	244	1	effective	effective	ADJ
aji-177	244	2	icb	icb	PROPN
aji-177	244	3	response	response	NOUN
aji-177	244	4	:	:	PUNCT
aji-177	244	5	in	in	ADP
aji-177	244	6	this	this	DET
aji-177	244	7	permissive	permissive	ADJ
aji-177	244	8	environment	environment	NOUN
aji-177	244	9	,	,	PUNCT
aji-177	244	10	the	the	DET
aji-177	244	11	administration	administration	NOUN
aji-177	244	12	of	of	ADP
aji-177	244	13	icb	icb	PROPN
aji-177	244	14	can	can	AUX
aji-177	244	15	effectively	effectively	ADV
aji-177	244	16	reinvigorate	reinvigorate	VERB
aji-177	244	17	these	these	DET
aji-177	244	18	functional	functional	ADJ
aji-177	244	19	,	,	PUNCT
aji-177	244	20	tumorinfiltrating	tumorinfiltrate	VERB
aji-177	244	21	t	t	NOUN
aji-177	244	22	cells	cell	NOUN
aji-177	244	23	,	,	PUNCT
aji-177	244	24	leading	lead	VERB
aji-177	244	25	to	to	ADP
aji-177	244	26	robust	robust	ADJ
aji-177	244	27	tumor	tumor	NOUN
aji-177	244	28	control	control	NOUN
aji-177	244	29	and	and	CCONJ
aji-177	244	30	clinical	clinical	ADJ
aji-177	244	31	response	response	NOUN
aji-177	244	32	(	(	PUNCT
aji-177	244	33	zhao	zhao	PROPN
aji-177	244	34	et	et	PROPN
aji-177	244	35	al	al	PROPN
aji-177	244	36	.	.	PROPN
aji-177	244	37	,	,	PUNCT
aji-177	244	38	2016	2016	NUM
aji-177	244	39	,	,	PUNCT
aji-177	244	40	mager	mager	PROPN
aji-177	244	41	et	et	PROPN
aji-177	244	42	al	al	PROPN
aji-177	244	43	.	.	PROPN
aji-177	244	44	,	,	PUNCT
aji-177	244	45	2020	2020	NUM
aji-177	244	46	,	,	PUNCT
aji-177	244	47	xi	xi	X
aji-177	244	48	et	et	PROPN
aji-177	244	49	al	al	PROPN
aji-177	244	50	.	.	PROPN
aji-177	244	51	,	,	PUNCT
aji-177	244	52	2022	2022	NUM
aji-177	244	53	)	)	PUNCT
aji-177	244	54	.	.	PUNCT
aji-177	245	1	4.2	4.2	NUM
aji-177	245	2	the	the	DET
aji-177	245	3	icb	icb	NOUN
aji-177	245	4	-	-	PUNCT
aji-177	245	5	resistant	resistant	ADJ
aji-177	245	6	cycle	cycle	NOUN
aji-177	245	7	:	:	PUNCT
aji-177	245	8	dysbiosis	dysbiosis	NOUN
aji-177	245	9	promotes	promote	VERB
aji-177	245	10	net	net	ADJ
aji-177	245	11	-	-	PUNCT
aji-177	245	12	driven	drive	VERB
aji-177	245	13	immunosuppression	immunosuppression	NOUN
aji-177	245	14	conversely	conversely	ADV
aji-177	245	15	,	,	PUNCT
aji-177	245	16	a	a	DET
aji-177	245	17	state	state	NOUN
aji-177	245	18	of	of	ADP
aji-177	245	19	dysbiosis	dysbiosis	NOUN
aji-177	245	20	,	,	PUNCT
aji-177	245	21	potentially	potentially	ADV
aji-177	245	22	driven	drive	VERB
aji-177	245	23	by	by	ADP
aji-177	245	24	antibiotics	antibiotic	NOUN
aji-177	245	25	,	,	PUNCT
aji-177	245	26	a	a	DET
aji-177	245	27	western	western	ADJ
aji-177	245	28	diet	diet	NOUN
aji-177	245	29	,	,	PUNCT
aji-177	245	30	or	or	CCONJ
aji-177	245	31	disease	disease	NOUN
aji-177	245	32	,	,	PUNCT
aji-177	245	33	initiates	initiate	VERB
aji-177	245	34	a	a	DET
aji-177	245	35	vicious	vicious	ADJ
aji-177	245	36	cycle	cycle	NOUN
aji-177	245	37	that	that	PRON
aji-177	245	38	culminates	culminate	VERB
aji-177	245	39	in	in	ADP
aji-177	245	40	icb	icb	PROPN
aji-177	245	41	resistance	resistance	NOUN
aji-177	245	42	.	.	PUNCT
aji-177	246	1	dysbiosis	dysbiosis	NOUN
aji-177	246	2	and	and	CCONJ
aji-177	246	3	metabolite	metabolite	NOUN
aji-177	246	4	imbalance	imbalance	NOUN
aji-177	246	5	:	:	PUNCT
aji-177	246	6	the	the	DET
aji-177	246	7	gut	gut	NOUN
aji-177	246	8	community	community	NOUN
aji-177	246	9	is	be	AUX
aji-177	246	10	depleted	deplete	VERB
aji-177	246	11	of	of	ADP
aji-177	246	12	beneficial	beneficial	ADJ
aji-177	246	13	metabolite	metabolite	NOUN
aji-177	246	14	producers	producer	NOUN
aji-177	246	15	.	.	PUNCT
aji-177	247	1	this	this	PRON
aji-177	247	2	leads	lead	VERB
aji-177	247	3	to	to	ADP
aji-177	247	4	low	low	ADJ
aji-177	247	5	systemic	systemic	ADJ
aji-177	247	6	levels	level	NOUN
aji-177	247	7	of	of	ADP
aji-177	247	8	scfas	scfas	NOUN
aji-177	247	9	and	and	CCONJ
aji-177	247	10	spermidine	spermidine	NOUN
aji-177	247	11	.	.	PUNCT
aji-177	248	1	concurrently	concurrently	ADV
aji-177	248	2	,	,	PUNCT
aji-177	248	3	there	there	PRON
aji-177	248	4	may	may	AUX
aji-177	248	5	be	be	AUX
aji-177	248	6	an	an	DET
aji-177	248	7	expansion	expansion	NOUN
aji-177	248	8	of	of	ADP
aji-177	248	9	bacteria	bacteria	NOUN
aji-177	248	10	that	that	PRON
aji-177	248	11	produce	produce	VERB
aji-177	248	12	proinflammatory	proinflammatory	ADJ
aji-177	248	13	metabolites	metabolite	NOUN
aji-177	248	14	or	or	CCONJ
aji-177	248	15	,	,	PUNCT
aji-177	248	16	through	through	ADP
aji-177	248	17	a	a	DET
aji-177	248	18	weakened	weaken	VERB
aji-177	248	19	gut	gut	NOUN
aji-177	248	20	barrier	barrier	NOUN
aji-177	248	21	,	,	PUNCT
aji-177	248	22	allow	allow	VERB
aji-177	248	23	the	the	DET
aji-177	248	24	translocation	translocation	NOUN
aji-177	248	25	of	of	ADP
aji-177	248	26	microbial	microbial	ADJ
aji-177	248	27	products	product	NOUN
aji-177	248	28	like	like	ADP
aji-177	248	29	lipopolysaccharide	lipopolysaccharide	ADV
aji-177	248	30	(	(	PUNCT
aji-177	248	31	lps	lps	PROPN
aji-177	248	32	)	)	PUNCT
aji-177	248	33	(	(	PUNCT
aji-177	248	34	ajibola	ajibola	PROPN
aji-177	248	35	and	and	CCONJ
aji-177	248	36	ayodele	ayodele	PROPN
aji-177	248	37	,	,	PUNCT
aji-177	248	38	2025	2025	NUM
aji-177	248	39	)	)	PUNCT
aji-177	248	40	.	.	PUNCT
aji-177	249	1	loss	loss	NOUN
aji-177	249	2	of	of	ADP
aji-177	249	3	netosis	netosis	NOUN
aji-177	249	4	suppression	suppression	NOUN
aji-177	249	5	:	:	PUNCT
aji-177	249	6	the	the	DET
aji-177	249	7	absence	absence	NOUN
aji-177	249	8	of	of	ADP
aji-177	249	9	the	the	DET
aji-177	249	10	"	"	PUNCT
aji-177	249	11	netosis	netosis	NOUN
aji-177	249	12	brake	brake	NOUN
aji-177	249	13	"	"	PUNCT
aji-177	249	14	(	(	PUNCT
aji-177	249	15	scfas	scfas	NOUN
aji-177	249	16	,	,	PUNCT
aji-177	249	17	spermidine	spermidine	NOUN
aji-177	249	18	)	)	PUNCT
aji-177	249	19	leaves	leave	VERB
aji-177	249	20	neutrophils	neutrophil	NOUN
aji-177	249	21	hypersensitive	hypersensitive	ADJ
aji-177	249	22	to	to	ADP
aji-177	249	23	activation	activation	NOUN
aji-177	249	24	signals	signal	NOUN
aji-177	249	25	.	.	PUNCT
aji-177	250	1	furthermore	furthermore	ADV
aji-177	250	2	,	,	PUNCT
aji-177	250	3	circulating	circulate	VERB
aji-177	250	4	lps	lps	PROPN
aji-177	250	5	and	and	CCONJ
aji-177	250	6	certain	certain	ADJ
aji-177	250	7	secondary	secondary	ADJ
aji-177	250	8	bile	bile	NOUN
aji-177	250	9	acids	acid	NOUN
aji-177	250	10	provide	provide	VERB
aji-177	250	11	direct	direct	ADJ
aji-177	250	12	triggers	trigger	NOUN
aji-177	250	13	for	for	ADP
aji-177	250	14	netosis	netosis	NOUN
aji-177	250	15	.	.	PUNCT
aji-177	251	1	net	net	NOUN
aji-177	251	2	-	-	PUNCT
aji-177	251	3	driven	drive	VERB
aji-177	251	4	immunosuppressive	immunosuppressive	ADJ
aji-177	251	5	tme	tme	NOUN
aji-177	251	6	:	:	PUNCT
aji-177	251	7	neutrophils	neutrophil	NOUN
aji-177	251	8	in	in	ADP
aji-177	251	9	the	the	DET
aji-177	251	10	tme	tme	NOUN
aji-177	251	11	readily	readily	ADV
aji-177	251	12	undergo	undergo	VERB
aji-177	251	13	netosis	netosis	NOUN
aji-177	251	14	,	,	PUNCT
aji-177	251	15	leading	lead	VERB
aji-177	251	16	to	to	ADP
aji-177	251	17	high	high	ADJ
aji-177	251	18	net	net	ADJ
aji-177	251	19	density	density	NOUN
aji-177	251	20	.	.	PUNCT
aji-177	252	1	these	these	DET
aji-177	252	2	nets	net	NOUN
aji-177	252	3	physically	physically	ADV
aji-177	252	4	trap	trap	VERB
aji-177	252	5	t	t	NOUN
aji-177	252	6	cells	cell	NOUN
aji-177	252	7	and	and	CCONJ
aji-177	252	8	prevent	prevent	VERB
aji-177	252	9	their	their	PRON
aji-177	252	10	infiltration	infiltration	NOUN
aji-177	252	11	(	(	PUNCT
aji-177	252	12	deng	deng	PROPN
aji-177	252	13	et	et	PROPN
aji-177	252	14	al	al	PROPN
aji-177	252	15	.	.	PROPN
aji-177	252	16	,	,	PUNCT
aji-177	252	17	2025	2025	NUM
aji-177	252	18	)	)	PUNCT
aji-177	252	19	.	.	PUNCT
aji-177	253	1	more	more	ADV
aji-177	253	2	critically	critically	ADV
aji-177	253	3	,	,	PUNCT
aji-177	253	4	net	net	ADJ
aji-177	253	5	components	component	NOUN
aji-177	253	6	have	have	AUX
aji-177	253	7	been	be	AUX
aji-177	253	8	shown	show	VERB
aji-177	253	9	to	to	PART
aji-177	253	10	directly	directly	ADV
aji-177	253	11	promote	promote	VERB
aji-177	253	12	t	t	NOUN
aji-177	253	13	cell	cell	NOUN
aji-177	253	14	exhaustion	exhaustion	NOUN
aji-177	253	15	by	by	ADP
aji-177	253	16	upregulating	upregulating	NOUN
aji-177	253	17	pd-1	pd-1	ADP
aji-177	253	18	expression	expression	NOUN
aji-177	253	19	and	and	CCONJ
aji-177	253	20	suppressing	suppress	VERB
aji-177	253	21	their	their	PRON
aji-177	253	22	proliferative	proliferative	ADJ
aji-177	253	23	and	and	CCONJ
aji-177	253	24	cytotoxic	cytotoxic	ADJ
aji-177	253	25	capacity	capacity	NOUN
aji-177	253	26	(	(	PUNCT
aji-177	253	27	cai	cai	X
aji-177	253	28	et	et	PROPN
aji-177	253	29	al	al	PROPN
aji-177	253	30	.	.	PROPN
aji-177	253	31	,	,	PUNCT
aji-177	253	32	2025	2025	NUM
aji-177	253	33	)	)	PUNCT
aji-177	253	34	.	.	PUNCT
aji-177	254	1	icb	icb	PROPN
aji-177	254	2	failure	failure	NOUN
aji-177	254	3	:	:	PUNCT
aji-177	254	4	in	in	ADP
aji-177	254	5	this	this	DET
aji-177	254	6	scenario	scenario	NOUN
aji-177	254	7	,	,	PUNCT
aji-177	254	8	the	the	DET
aji-177	254	9	tme	tme	NOUN
aji-177	254	10	is	be	AUX
aji-177	254	11	characterized	characterize	VERB
aji-177	254	12	by	by	ADP
aji-177	254	13	excluded	exclude	VERB
aji-177	254	14	and	and	CCONJ
aji-177	254	15	profoundly	profoundly	ADV
aji-177	254	16	exhausted	exhausted	ADJ
aji-177	254	17	t	t	NOUN
aji-177	254	18	cells	cell	NOUN
aji-177	254	19	.	.	PUNCT
aji-177	255	1	even	even	ADV
aji-177	255	2	when	when	SCONJ
aji-177	255	3	pd-1	pd-1	ADV
aji-177	255	4	is	be	AUX
aji-177	255	5	blocked	block	VERB
aji-177	255	6	by	by	ADP
aji-177	255	7	icb	icb	PROPN
aji-177	255	8	,	,	PUNCT
aji-177	255	9	the	the	DET
aji-177	255	10	t	t	PROPN
aji-177	255	11	cells	cell	NOUN
aji-177	255	12	are	be	AUX
aji-177	255	13	too	too	ADV
aji-177	255	14	dysfunctional	dysfunctional	ADJ
aji-177	255	15	or	or	CCONJ
aji-177	255	16	physically	physically	ADV
aji-177	255	17	sequestered	sequester	VERB
aji-177	255	18	to	to	PART
aji-177	255	19	mount	mount	VERB
aji-177	255	20	an	an	DET
aji-177	255	21	effective	effective	ADJ
aji-177	255	22	anti	anti	ADJ
aji-177	255	23	-	-	ADJ
aji-177	255	24	tumor	tumor	ADJ
aji-177	255	25	response	response	NOUN
aji-177	255	26	,	,	PUNCT
aji-177	255	27	resulting	result	VERB
aji-177	255	28	in	in	ADP
aji-177	255	29	primary	primary	ADJ
aji-177	255	30	therapeutic	therapeutic	ADJ
aji-177	255	31	resistance	resistance	NOUN
aji-177	255	32	.	.	PUNCT
aji-177	256	1	table	table	NOUN
aji-177	256	2	3	3	NUM
aji-177	256	3	.	.	PUNCT
aji-177	257	1	the	the	DET
aji-177	257	2	two	two	NUM
aji-177	257	3	states	state	NOUN
aji-177	257	4	of	of	ADP
aji-177	257	5	the	the	DET
aji-177	257	6	gut	gut	NOUN
aji-177	257	7	-	-	PUNCT
aji-177	257	8	net	net	NOUN
aji-177	257	9	-	-	PUNCT
aji-177	257	10	icb	icb	PROPN
aji-177	257	11	axis	axis	NOUN
aji-177	257	12	feature	feature	NOUN
aji-177	257	13	netosis	netosis	NOUN
aji-177	257	14	-	-	PUNCT
aji-177	257	15	suppressive	suppressive	NOUN
aji-177	257	16	,	,	PUNCT
aji-177	257	17	icbpermissive	icbpermissive	ADJ
aji-177	257	18	state	state	NOUN
aji-177	257	19	netosis	netosis	NOUN
aji-177	257	20	-	-	PUNCT
aji-177	257	21	promotive	promotive	ADJ
aji-177	257	22	,	,	PUNCT
aji-177	257	23	icb	icb	NOUN
aji-177	257	24	-	-	PUNCT
aji-177	257	25	resistant	resistant	ADJ
aji-177	257	26	state	state	NOUN
aji-177	257	27	gut	gut	NOUN
aji-177	257	28	microbiome	microbiome	NOUN
aji-177	257	29	profile	profile	NOUN
aji-177	257	30	"	"	PUNCT
aji-177	257	31	favorable	favorable	ADJ
aji-177	257	32	"	"	PUNCT
aji-177	257	33	/	/	SYM
aji-177	257	34	eubiotic	eubiotic	ADJ
aji-177	257	35	.	.	PUNCT
aji-177	258	1	enriched	enrich	VERB
aji-177	258	2	with	with	ADP
aji-177	258	3	scfa	scfa	ADJ
aji-177	258	4	-	-	PUNCT
aji-177	258	5	producers	producer	NOUN
aji-177	258	6	polyamine	polyamine	NOUN
aji-177	258	7	-	-	PUNCT
aji-177	258	8	producers	producer	NOUN
aji-177	258	9	,	,	PUNCT
aji-177	258	10	and	and	CCONJ
aji-177	258	11	ahrligand	ahrligand	VERB
aji-177	258	12	generators	generator	NOUN
aji-177	258	13	.	.	PUNCT
aji-177	259	1	"	"	PUNCT
aji-177	259	2	unfavorable	unfavorable	ADJ
aji-177	259	3	"	"	PUNCT
aji-177	259	4	/	/	SYM
aji-177	259	5	dysbiotic	dysbiotic	NOUN
aji-177	259	6	.	.	PUNCT
aji-177	260	1	enriched	enrich	VERB
aji-177	260	2	with	with	ADP
aji-177	260	3	pathobionts	pathobiont	NOUN
aji-177	260	4	,	,	PUNCT
aji-177	260	5	reduced	reduce	VERB
aji-177	260	6	microbial	microbial	ADJ
aji-177	260	7	diversity	diversity	NOUN
aji-177	260	8	,	,	PUNCT
aji-177	260	9	and	and	CCONJ
aji-177	260	10	bacteria	bacteria	NOUN
aji-177	260	11	producing	produce	VERB
aji-177	260	12	pro	pro	ADJ
aji-177	260	13	-	-	ADJ
aji-177	260	14	inflammatory	inflammatory	ADJ
aji-177	260	15	metabolites	metabolite	NOUN
aji-177	260	16	.	.	PUNCT
aji-177	261	1	systemic	systemic	ADJ
aji-177	261	2	metabolite	metabolite	NOUN
aji-177	261	3	profile	profile	VERB
aji-177	261	4	high	high	ADJ
aji-177	261	5	circulating	circulate	VERB
aji-177	261	6	levels	level	NOUN
aji-177	261	7	of	of	ADP
aji-177	261	8	butyrate	butyrate	NOUN
aji-177	261	9	,	,	PUNCT
aji-177	261	10	propionate	propionate	NOUN
aji-177	261	11	,	,	PUNCT
aji-177	261	12	spermidine	spermidine	NOUN
aji-177	261	13	,	,	PUNCT
aji-177	261	14	and	and	CCONJ
aji-177	261	15	indoles	indole	NOUN
aji-177	261	16	.	.	PUNCT
aji-177	262	1	balanced	balanced	ADJ
aji-177	262	2	secondary	secondary	ADJ
aji-177	262	3	bile	bile	NOUN
aji-177	262	4	acid	acid	NOUN
aji-177	262	5	ratio	ratio	NOUN
aji-177	262	6	.	.	PUNCT
aji-177	263	1	low	low	ADJ
aji-177	263	2	levels	level	NOUN
aji-177	263	3	of	of	ADP
aji-177	263	4	beneficial	beneficial	ADJ
aji-177	263	5	metabolites	metabolite	NOUN
aji-177	263	6	.	.	PUNCT
aji-177	264	1	high	high	ADJ
aji-177	264	2	levels	level	NOUN
aji-177	264	3	of	of	ADP
aji-177	264	4	pro	pro	ADJ
aji-177	264	5	-	-	ADJ
aji-177	264	6	inflammatory	inflammatory	ADJ
aji-177	264	7	secondary	secondary	ADJ
aji-177	264	8	bile	bile	NOUN
aji-177	264	9	acids	acid	NOUN
aji-177	264	10	.	.	PUNCT
aji-177	265	1	impact	impact	NOUN
aji-177	265	2	on	on	ADP
aji-177	265	3	neutrophils	neutrophil	NOUN
aji-177	265	4	&	&	CCONJ
aji-177	265	5	netosis	netosis	PROPN
aji-177	265	6	suppressed	suppress	VERB
aji-177	265	7	pathological	pathological	ADJ
aji-177	265	8	netosis	netosis	NOUN
aji-177	265	9	.	.	PUNCT
aji-177	266	1	metabolites	metabolite	NOUN
aji-177	266	2	directly	directly	ADV
aji-177	266	3	inhibit	inhibit	VERB
aji-177	266	4	pad4	pad4	NOUN
aji-177	266	5	,	,	PUNCT
aji-177	266	6	reduce	reduce	VERB
aji-177	266	7	ros	ros	PROPN
aji-177	266	8	,	,	PUNCT
aji-177	266	9	and	and	CCONJ
aji-177	266	10	block	block	NOUN
aji-177	266	11	hdacs	hdac	NOUN
aji-177	266	12	.	.	PUNCT
aji-177	267	1	neutrophils	neutrophil	NOUN
aji-177	267	2	are	be	AUX
aji-177	267	3	less	less	ADV
aji-177	267	4	prone	prone	ADJ
aji-177	267	5	to	to	ADP
aji-177	267	6	excessive	excessive	ADJ
aji-177	267	7	net	net	ADJ
aji-177	267	8	release	release	NOUN
aji-177	267	9	.	.	PUNCT
aji-177	268	1	promoted	promote	VERB
aji-177	268	2	pathological	pathological	ADJ
aji-177	268	3	netosis	netosis	NOUN
aji-177	268	4	.	.	PUNCT
aji-177	269	1	lack	lack	NOUN
aji-177	269	2	of	of	ADP
aji-177	269	3	suppression	suppression	NOUN
aji-177	269	4	and	and	CCONJ
aji-177	269	5	presence	presence	NOUN
aji-177	269	6	of	of	ADP
aji-177	269	7	inflammatory	inflammatory	ADJ
aji-177	269	8	inducers	inducer	NOUN
aji-177	269	9	lead	lead	VERB
aji-177	269	10	to	to	ADP
aji-177	269	11	rampant	rampant	ADJ
aji-177	269	12	net	net	ADJ
aji-177	269	13	formation	formation	NOUN
aji-177	269	14	.	.	PUNCT
aji-177	270	1	tumor	tumor	NOUN
aji-177	270	2	microenvironment	microenvironment	NOUN
aji-177	270	3	(	(	PUNCT
aji-177	270	4	tme	tme	NOUN
aji-177	270	5	)	)	PUNCT
aji-177	270	6	low	low	ADJ
aji-177	270	7	net	net	ADJ
aji-177	270	8	density	density	NOUN
aji-177	270	9	enhanced	enhance	VERB
aji-177	270	10	t	t	PROPN
aji-177	270	11	-	-	PUNCT
aji-177	270	12	cell	cell	NOUN
aji-177	270	13	infiltration	infiltration	NOUN
aji-177	270	14	:	:	PUNCT
aji-177	270	15	physical	physical	ADJ
aji-177	270	16	barrier	barrier	NOUN
aji-177	270	17	is	be	AUX
aji-177	270	18	removed	remove	VERB
aji-177	270	19	.	.	PUNCT
aji-177	271	1	functional	functional	ADJ
aji-177	271	2	t	t	PROPN
aji-177	271	3	-	-	PUNCT
aji-177	271	4	cells	cell	NOUN
aji-177	271	5	:	:	PUNCT
aji-177	271	6	reduced	reduce	VERB
aji-177	271	7	tcell	tcell	NOUN
aji-177	271	8	exhaustion	exhaustion	NOUN
aji-177	271	9	and	and	CCONJ
aji-177	271	10	impairment	impairment	NOUN
aji-177	271	11	.	.	PUNCT
aji-177	272	1	favorable	favorable	ADJ
aji-177	272	2	cd8+/treg	cd8+/treg	PROPN
aji-177	272	3	ratio	ratio	NOUN
aji-177	272	4	.	.	PUNCT
aji-177	273	1	high	high	ADJ
aji-177	273	2	net	net	ADJ
aji-177	273	3	density	density	NOUN
aji-177	273	4	impaired	impair	VERB
aji-177	273	5	t	t	PROPN
aji-177	273	6	-	-	PUNCT
aji-177	273	7	cell	cell	NOUN
aji-177	273	8	infiltration	infiltration	NOUN
aji-177	273	9	:	:	PUNCT
aji-177	273	10	nets	net	NOUN
aji-177	273	11	form	form	VERB
aji-177	273	12	a	a	DET
aji-177	273	13	physical	physical	ADJ
aji-177	273	14	barrier	barrier	NOUN
aji-177	273	15	.	.	PUNCT
aji-177	274	1	t	t	NOUN
aji-177	274	2	-	-	PUNCT
aji-177	274	3	cell	cell	NOUN
aji-177	274	4	exhaustion	exhaustion	NOUN
aji-177	274	5	:	:	PUNCT
aji-177	274	6	net	net	ADJ
aji-177	274	7	components	component	NOUN
aji-177	274	8	directly	directly	ADV
aji-177	274	9	suppress	suppress	VERB
aji-177	274	10	t	t	NOUN
aji-177	274	11	-	-	PUNCT
aji-177	274	12	cell	cell	NOUN
aji-177	274	13	function	function	NOUN
aji-177	274	14	.	.	PUNCT
aji-177	275	1	immunosuppressive	immunosuppressive	ADJ
aji-177	275	2	milieu	milieu	NOUN
aji-177	275	3	.	.	PUNCT
aji-177	276	1	final	final	PROPN
aji-177	276	2	icb	icb	PROPN
aji-177	276	3	outcome	outcome	NOUN
aji-177	276	4	responsive	responsive	ADJ
aji-177	276	5	.	.	PUNCT
aji-177	277	1	checkpoint	checkpoint	NOUN
aji-177	277	2	inhibitors	inhibitor	NOUN
aji-177	277	3	effectively	effectively	ADV
aji-177	277	4	reinvigorate	reinvigorate	VERB
aji-177	277	5	pre	pre	ADJ
aji-177	277	6	-	-	ADJ
aji-177	277	7	existing	existing	ADJ
aji-177	277	8	,	,	PUNCT
aji-177	277	9	functional	functional	ADJ
aji-177	277	10	,	,	PUNCT
aji-177	277	11	and	and	CCONJ
aji-177	277	12	infiltrated	infiltrate	VERB
aji-177	277	13	t	t	NOUN
aji-177	277	14	cells	cell	NOUN
aji-177	277	15	,	,	PUNCT
aji-177	277	16	leading	lead	VERB
aji-177	277	17	to	to	ADP
aji-177	277	18	tumor	tumor	NOUN
aji-177	277	19	cell	cell	NOUN
aji-177	277	20	killing	killing	NOUN
aji-177	277	21	.	.	PUNCT
aji-177	278	1	refractory	refractory	NOUN
aji-177	278	2	.	.	PUNCT
aji-177	279	1	t	t	PROPN
aji-177	279	2	cells	cell	NOUN
aji-177	279	3	are	be	AUX
aji-177	279	4	excluded	exclude	VERB
aji-177	279	5	,	,	PUNCT
aji-177	279	6	dysfunctional	dysfunctional	ADJ
aji-177	279	7	,	,	PUNCT
aji-177	279	8	and	and	CCONJ
aji-177	279	9	exhausted	exhausted	ADJ
aji-177	279	10	;	;	PUNCT
aji-177	279	11	icb	icb	PROPN
aji-177	279	12	fails	fail	VERB
aji-177	279	13	to	to	PART
aji-177	279	14	initiate	initiate	VERB
aji-177	279	15	an	an	DET
aji-177	279	16	effective	effective	ADJ
aji-177	279	17	anti	anti	ADJ
aji-177	279	18	-	-	ADJ
aji-177	279	19	tumor	tumor	ADJ
aji-177	279	20	response	response	NOUN
aji-177	279	21	.	.	PUNCT
aji-177	280	1	jimoh	jimoh	PROPN
aji-177	280	2	et	et	PROPN
aji-177	280	3	al	al	PROPN
aji-177	280	4	.	.	PROPN
aji-177	280	5	;	;	PUNCT
aji-177	280	6	asian	asian	PROPN
aji-177	280	7	j.	j.	PROPN
aji-177	280	8	immunol	immunol	PROPN
aji-177	280	9	.	.	PROPN
aji-177	280	10	,	,	PUNCT
aji-177	280	11	vol	vol	NOUN
aji-177	280	12	.	.	PROPN
aji-177	280	13	8	8	NUM
aji-177	280	14	,	,	PUNCT
aji-177	280	15	no	no	INTJ
aji-177	280	16	.	.	NOUN
aji-177	280	17	1	1	NUM
aji-177	280	18	,	,	PUNCT
aji-177	280	19	pp	pp	ADJ
aji-177	280	20	.	.	PUNCT
aji-177	281	1	257	257	NUM
aji-177	281	2	-	-	SYM
aji-177	281	3	268	268	NUM
aji-177	281	4	,	,	PUNCT
aji-177	281	5	2025	2025	NUM
aji-177	281	6	;	;	PUNCT
aji-177	281	7	article	article	NOUN
aji-177	281	8	no.aji.147982	no.aji.147982	VERB
aji-177	281	9	265	265	NUM
aji-177	281	10	fig	fig	NOUN
aji-177	281	11	.	.	PUNCT
aji-177	282	1	2	2	X
aji-177	282	2	.	.	NUM
aji-177	282	3	acquired	acquire	VERB
aji-177	282	4	resistance	resistance	NOUN
aji-177	282	5	to	to	ADP
aji-177	282	6	immune	immune	ADJ
aji-177	282	7	checkpoint	checkpoint	NOUN
aji-177	282	8	blockades	blockade	NOUN
aji-177	282	9	(	(	PUNCT
aji-177	282	10	bi	bi	NOUN
aji-177	282	11	et	et	PROPN
aji-177	282	12	al	al	PROPN
aji-177	282	13	.	.	PROPN
aji-177	282	14	,	,	PUNCT
aji-177	282	15	2025	2025	NUM
aji-177	282	16	)	)	PUNCT
aji-177	282	17	4.3	4.3	NUM
aji-177	282	18	therapeutic	therapeutic	ADJ
aji-177	282	19	implications	implication	NOUN
aji-177	282	20	of	of	ADP
aji-177	282	21	the	the	DET
aji-177	282	22	axis	axis	NOUN
aji-177	282	23	this	this	DET
aji-177	282	24	model	model	NOUN
aji-177	282	25	directly	directly	ADV
aji-177	282	26	suggests	suggest	VERB
aji-177	282	27	novel	novel	ADJ
aji-177	282	28	therapeutic	therapeutic	ADJ
aji-177	282	29	strategies	strategy	NOUN
aji-177	282	30	aimed	aim	VERB
aji-177	282	31	at	at	ADP
aji-177	282	32	interrupting	interrupt	VERB
aji-177	282	33	the	the	DET
aji-177	282	34	resistant	resistant	ADJ
aji-177	282	35	cycle	cycle	NOUN
aji-177	282	36	and	and	CCONJ
aji-177	282	37	promoting	promote	VERB
aji-177	282	38	the	the	DET
aji-177	282	39	permissive	permissive	ADJ
aji-177	282	40	one	one	NOUN
aji-177	282	41	.	.	PUNCT
aji-177	283	1	these	these	DET
aji-177	283	2	interventions	intervention	NOUN
aji-177	283	3	can	can	AUX
aji-177	283	4	target	target	VERB
aji-177	283	5	different	different	ADJ
aji-177	283	6	nodes	node	NOUN
aji-177	283	7	of	of	ADP
aji-177	283	8	the	the	DET
aji-177	283	9	axis	axis	NOUN
aji-177	283	10	:	:	PUNCT
aji-177	283	11	targeting	target	VERB
aji-177	283	12	the	the	DET
aji-177	283	13	gut	gut	NOUN
aji-177	283	14	:	:	PUNCT
aji-177	283	15	using	use	VERB
aji-177	283	16	prebiotics	prebiotic	NOUN
aji-177	283	17	,	,	PUNCT
aji-177	283	18	probiotics	probiotic	NOUN
aji-177	283	19	,	,	PUNCT
aji-177	283	20	or	or	CCONJ
aji-177	283	21	fmt	fmt	VERB
aji-177	283	22	to	to	PART
aji-177	283	23	establish	establish	VERB
aji-177	283	24	a	a	DET
aji-177	283	25	netosis	netosis	NOUN
aji-177	283	26	-	-	PUNCT
aji-177	283	27	suppressive	suppressive	ADJ
aji-177	283	28	microbiome	microbiome	NOUN
aji-177	283	29	.	.	PUNCT
aji-177	284	1	targeting	target	VERB
aji-177	284	2	the	the	DET
aji-177	284	3	metabolite	metabolite	NOUN
aji-177	284	4	:	:	PUNCT
aji-177	284	5	using	use	VERB
aji-177	284	6	postbiotic	postbiotic	ADJ
aji-177	284	7	supplements	supplement	NOUN
aji-177	284	8	to	to	PART
aji-177	284	9	directly	directly	ADV
aji-177	284	10	deliver	deliver	VERB
aji-177	284	11	the	the	DET
aji-177	284	12	inhibitory	inhibitory	ADJ
aji-177	284	13	signals	signal	NOUN
aji-177	284	14	.	.	PUNCT
aji-177	285	1	targeting	target	VERB
aji-177	285	2	netosis	netosis	NOUN
aji-177	285	3	:	:	PUNCT
aji-177	285	4	using	use	VERB
aji-177	285	5	pharmacological	pharmacological	ADJ
aji-177	285	6	pad4	pad4	NOUN
aji-177	285	7	inhibitors	inhibitor	NOUN
aji-177	285	8	(	(	PUNCT
aji-177	285	9	e.g.	e.g.	ADV
aji-177	285	10	,	,	PUNCT
aji-177	285	11	gsk484	gsk484	NOUN
aji-177	285	12	)	)	PUNCT
aji-177	285	13	or	or	CCONJ
aji-177	285	14	dnase	dnase	VERB
aji-177	285	15	i	i	PRON
aji-177	285	16	to	to	PART
aji-177	285	17	directly	directly	ADV
aji-177	285	18	prevent	prevent	VERB
aji-177	285	19	net	net	ADJ
aji-177	285	20	formation	formation	NOUN
aji-177	285	21	or	or	CCONJ
aji-177	285	22	degrade	degrade	VERB
aji-177	285	23	existing	exist	VERB
aji-177	285	24	nets	net	NOUN
aji-177	285	25	,	,	PUNCT
aji-177	285	26	thereby	thereby	ADV
aji-177	285	27	breaking	break	VERB
aji-177	285	28	the	the	DET
aji-177	285	29	immunosuppressive	immunosuppressive	ADJ
aji-177	285	30	barrier	barrier	NOUN
aji-177	285	31	and	and	CCONJ
aji-177	285	32	potentially	potentially	ADV
aji-177	285	33	synergizing	synergize	VERB
aji-177	285	34	with	with	ADP
aji-177	285	35	icb	icb	PROPN
aji-177	285	36	(	(	PUNCT
aji-177	285	37	bi	bi	NOUN
aji-177	285	38	et	et	PROPN
aji-177	285	39	al	al	PROPN
aji-177	285	40	.	.	PROPN
aji-177	285	41	,	,	PUNCT
aji-177	285	42	2025	2025	NUM
aji-177	285	43	,	,	PUNCT
aji-177	285	44	zhang	zhang	PROPN
aji-177	285	45	et	et	PROPN
aji-177	285	46	al	al	PROPN
aji-177	285	47	.	.	PROPN
aji-177	285	48	,	,	PUNCT
aji-177	285	49	2025	2025	NUM
aji-177	285	50	)	)	PUNCT
aji-177	285	51	.	.	PUNCT
aji-177	286	1	the	the	DET
aji-177	286	2	gut	gut	NOUN
aji-177	286	3	-	-	PUNCT
aji-177	286	4	net	net	NOUN
aji-177	286	5	-	-	PUNCT
aji-177	286	6	icb	icb	PROPN
aji-177	286	7	axis	axis	NOUN
aji-177	286	8	provides	provide	VERB
aji-177	286	9	a	a	DET
aji-177	286	10	powerful	powerful	ADJ
aji-177	286	11	,	,	PUNCT
aji-177	286	12	mechanistic	mechanistic	ADJ
aji-177	286	13	model	model	NOUN
aji-177	286	14	that	that	PRON
aji-177	286	15	integrates	integrate	VERB
aji-177	286	16	the	the	DET
aji-177	286	17	fields	field	NOUN
aji-177	286	18	of	of	ADP
aji-177	286	19	microbiome	microbiome	ADJ
aji-177	286	20	research	research	NOUN
aji-177	286	21	,	,	PUNCT
aji-177	286	22	neutrophil	neutrophil	ADJ
aji-177	286	23	biology	biology	NOUN
aji-177	286	24	,	,	PUNCT
aji-177	286	25	and	and	CCONJ
aji-177	286	26	cancer	cancer	NOUN
aji-177	286	27	immunotherapy	immunotherapy	NOUN
aji-177	286	28	(	(	PUNCT
aji-177	286	29	zhou	zhou	PROPN
aji-177	286	30	et	et	PROPN
aji-177	286	31	al	al	PROPN
aji-177	286	32	.	.	PROPN
aji-177	286	33	,	,	PUNCT
aji-177	286	34	2021	2021	NUM
aji-177	286	35	)	)	PUNCT
aji-177	286	36	.	.	PUNCT
aji-177	287	1	it	it	PRON
aji-177	287	2	explains	explain	VERB
aji-177	287	3	how	how	SCONJ
aji-177	287	4	a	a	DET
aji-177	287	5	systemic	systemic	ADJ
aji-177	287	6	factor	factor	NOUN
aji-177	287	7	of	of	ADP
aji-177	287	8	the	the	DET
aji-177	287	9	gut	gut	NOUN
aji-177	287	10	microbiome	microbiome	NOUN
aji-177	287	11	can	can	AUX
aji-177	287	12	locally	locally	ADV
aji-177	287	13	determine	determine	VERB
aji-177	287	14	treatment	treatment	NOUN
aji-177	287	15	efficacy	efficacy	NOUN
aji-177	287	16	by	by	ADP
aji-177	287	17	controlling	control	VERB
aji-177	287	18	a	a	DET
aji-177	287	19	specific	specific	ADJ
aji-177	287	20	innate	innate	ADJ
aji-177	287	21	immune	immune	ADJ
aji-177	287	22	process	process	NOUN
aji-177	287	23	,	,	PUNCT
aji-177	287	24	netosis	netosis	ADV
aji-177	287	25	,	,	PUNCT
aji-177	287	26	that	that	PRON
aji-177	287	27	directly	directly	ADV
aji-177	287	28	shapes	shape	VERB
aji-177	287	29	the	the	DET
aji-177	287	30	adaptive	adaptive	ADJ
aji-177	287	31	anti	anti	ADJ
aji-177	287	32	-	-	ADJ
aji-177	287	33	tumor	tumor	ADJ
aji-177	287	34	response	response	NOUN
aji-177	287	35	(	(	PUNCT
aji-177	287	36	cai	cai	X
aji-177	287	37	et	et	PROPN
aji-177	287	38	al	al	PROPN
aji-177	287	39	.	.	PROPN
aji-177	287	40	,	,	PUNCT
aji-177	287	41	2025	2025	NUM
aji-177	287	42	,	,	PUNCT
aji-177	287	43	pirini	pirini	PROPN
aji-177	287	44	et	et	NOUN
aji-177	287	45	al	al	PROPN
aji-177	287	46	.	.	PROPN
aji-177	287	47	,	,	PUNCT
aji-177	287	48	2025	2025	NUM
aji-177	287	49	)	)	PUNCT
aji-177	287	50	.	.	PUNCT
aji-177	288	1	5	5	X
aji-177	288	2	.	.	X
aji-177	288	3	conclusion	conclusion	NOUN
aji-177	288	4	the	the	DET
aji-177	288	5	intricate	intricate	ADJ
aji-177	288	6	interplay	interplay	NOUN
aji-177	288	7	between	between	ADP
aji-177	288	8	the	the	DET
aji-177	288	9	gut	gut	NOUN
aji-177	288	10	microbiome	microbiome	NOUN
aji-177	288	11	,	,	PUNCT
aji-177	288	12	host	host	NOUN
aji-177	288	13	immunity	immunity	NOUN
aji-177	288	14	,	,	PUNCT
aji-177	288	15	and	and	CCONJ
aji-177	288	16	cancer	cancer	NOUN
aji-177	288	17	therapy	therapy	NOUN
aji-177	288	18	continues	continue	VERB
aji-177	288	19	to	to	PART
aji-177	288	20	redefine	redefine	VERB
aji-177	288	21	our	our	PRON
aji-177	288	22	understanding	understanding	NOUN
aji-177	288	23	of	of	ADP
aji-177	288	24	oncobiology	oncobiology	NOUN
aji-177	288	25	.	.	PUNCT
aji-177	289	1	this	this	DET
aji-177	289	2	review	review	NOUN
aji-177	289	3	has	have	AUX
aji-177	289	4	synthesized	synthesize	VERB
aji-177	289	5	compelling	compelling	ADJ
aji-177	289	6	evidence	evidence	NOUN
aji-177	289	7	to	to	PART
aji-177	289	8	establish	establish	VERB
aji-177	289	9	a	a	DET
aji-177	289	10	novel	novel	ADJ
aji-177	289	11	and	and	CCONJ
aji-177	289	12	critical	critical	ADJ
aji-177	289	13	pathway	pathway	NOUN
aji-177	289	14	:	:	PUNCT
aji-177	289	15	the	the	DET
aji-177	289	16	gut	gut	NOUN
aji-177	289	17	-	-	PUNCT
aji-177	289	18	net	net	NOUN
aji-177	289	19	-	-	PUNCT
aji-177	289	20	icb	icb	NOUN
aji-177	289	21	axis	axis	NOUN
aji-177	289	22	.	.	PUNCT
aji-177	290	1	we	we	PRON
aji-177	290	2	have	have	AUX
aji-177	290	3	delineated	delineate	VERB
aji-177	290	4	a	a	DET
aji-177	290	5	mechanistic	mechanistic	ADJ
aji-177	290	6	framework	framework	NOUN
aji-177	290	7	wherein	wherein	SCONJ
aji-177	290	8	gut	gut	VERB
aji-177	290	9	microbial	microbial	ADJ
aji-177	290	10	metabolites	metabolite	NOUN
aji-177	290	11	serve	serve	VERB
aji-177	290	12	as	as	ADP
aji-177	290	13	pivotal	pivotal	ADJ
aji-177	290	14	systemic	systemic	ADJ
aji-177	290	15	regulators	regulator	NOUN
aji-177	290	16	of	of	ADP
aji-177	290	17	neutrophil	neutrophil	ADJ
aji-177	290	18	extracellular	extracellular	ADJ
aji-177	290	19	trap	trap	NOUN
aji-177	290	20	(	(	PUNCT
aji-177	290	21	net	net	ADJ
aji-177	290	22	)	)	PUNCT
aji-177	290	23	formation	formation	NOUN
aji-177	290	24	,	,	PUNCT
aji-177	290	25	which	which	PRON
aji-177	290	26	in	in	ADP
aji-177	290	27	turn	turn	NOUN
aji-177	290	28	exerts	exert	VERB
aji-177	290	29	a	a	DET
aji-177	290	30	profound	profound	ADJ
aji-177	290	31	influence	influence	NOUN
aji-177	290	32	on	on	ADP
aji-177	290	33	the	the	DET
aji-177	290	34	efficacy	efficacy	NOUN
aji-177	290	35	of	of	ADP
aji-177	290	36	immune	immune	ADJ
aji-177	290	37	checkpoint	checkpoint	NOUN
aji-177	290	38	blockade	blockade	NOUN
aji-177	290	39	(	(	PUNCT
aji-177	290	40	icb	icb	PROPN
aji-177	290	41	)	)	PUNCT
aji-177	290	42	.	.	PUNCT
aji-177	291	1	the	the	DET
aji-177	291	2	model	model	NOUN
aji-177	291	3	posits	posit	VERB
aji-177	291	4	two	two	NUM
aji-177	291	5	divergent	divergent	ADJ
aji-177	291	6	states	state	NOUN
aji-177	291	7	.	.	PUNCT
aji-177	292	1	a	a	DET
aji-177	292	2	favorable	favorable	ADJ
aji-177	292	3	gut	gut	NOUN
aji-177	292	4	microbiome	microbiome	NOUN
aji-177	292	5	,	,	PUNCT
aji-177	292	6	characterized	characterize	VERB
aji-177	292	7	by	by	ADP
aji-177	292	8	producers	producer	NOUN
aji-177	292	9	of	of	ADP
aji-177	292	10	short	short	ADJ
aji-177	292	11	-	-	PUNCT
aji-177	292	12	chain	chain	NOUN
aji-177	292	13	fatty	fatty	NOUN
aji-177	292	14	acids	acid	NOUN
aji-177	292	15	(	(	PUNCT
aji-177	292	16	scfas	scfas	NOUN
aji-177	292	17	)	)	PUNCT
aji-177	292	18	,	,	PUNCT
aji-177	292	19	polyamines	polyamine	NOUN
aji-177	292	20	,	,	PUNCT
aji-177	292	21	and	and	CCONJ
aji-177	292	22	ahr	ahr	PROPN
aji-177	292	23	ligands	ligand	NOUN
aji-177	292	24	,	,	PUNCT
aji-177	292	25	generates	generate	VERB
aji-177	292	26	a	a	DET
aji-177	292	27	metabolite	metabolite	NOUN
aji-177	292	28	profile	profile	NOUN
aji-177	292	29	that	that	PRON
aji-177	292	30	systemically	systemically	ADV
aji-177	292	31	suppresses	suppress	VERB
aji-177	292	32	pathological	pathological	ADJ
aji-177	292	33	netosis	netosis	NOUN
aji-177	292	34	.	.	PUNCT
aji-177	293	1	this	this	PRON
aji-177	293	2	creates	create	VERB
aji-177	293	3	a	a	DET
aji-177	293	4	tumor	tumor	NOUN
aji-177	293	5	microenvironment	microenvironment	NOUN
aji-177	293	6	(	(	PUNCT
aji-177	293	7	tme	tme	NOUN
aji-177	293	8	)	)	PUNCT
aji-177	293	9	that	that	PRON
aji-177	293	10	is	be	AUX
aji-177	293	11	permissive	permissive	ADJ
aji-177	293	12	to	to	AUX
aji-177	293	13	tcell	tcell	NOUN
aji-177	293	14	infiltration	infiltration	NOUN
aji-177	293	15	and	and	CCONJ
aji-177	293	16	function	function	NOUN
aji-177	293	17	,	,	PUNCT
aji-177	293	18	thereby	thereby	ADV
aji-177	293	19	enabling	enable	VERB
aji-177	293	20	a	a	DET
aji-177	293	21	robust	robust	ADJ
aji-177	293	22	response	response	NOUN
aji-177	293	23	to	to	ADP
aji-177	293	24	icb	icb	PROPN
aji-177	293	25	.	.	PUNCT
aji-177	294	1	conversely	conversely	ADV
aji-177	294	2	,	,	PUNCT
aji-177	294	3	a	a	DET
aji-177	294	4	state	state	NOUN
aji-177	294	5	of	of	ADP
aji-177	294	6	dysbiosis	dysbiosis	NOUN
aji-177	294	7	fails	fail	VERB
aji-177	294	8	to	to	PART
aji-177	294	9	provide	provide	VERB
aji-177	294	10	these	these	DET
aji-177	294	11	suppressive	suppressive	ADJ
aji-177	294	12	signals	signal	NOUN
aji-177	294	13	and	and	CCONJ
aji-177	294	14	may	may	AUX
aji-177	294	15	even	even	ADV
aji-177	294	16	promote	promote	VERB
aji-177	294	17	netosis	netosis	PRON
aji-177	294	18	,	,	PUNCT
aji-177	294	19	leading	lead	VERB
aji-177	294	20	to	to	ADP
aji-177	294	21	a	a	DET
aji-177	294	22	net	net	NOUN
aji-177	294	23	-	-	PUNCT
aji-177	294	24	rich	rich	ADJ
aji-177	294	25	,	,	PUNCT
aji-177	294	26	immunosuppressive	immunosuppressive	ADJ
aji-177	294	27	tme	tme	NOUN
aji-177	294	28	that	that	PRON
aji-177	294	29	fosters	foster	VERB
aji-177	294	30	t	t	PROPN
aji-177	294	31	-	-	PUNCT
aji-177	294	32	cell	cell	NOUN
aji-177	294	33	exclusion	exclusion	NOUN
aji-177	294	34	and	and	CCONJ
aji-177	294	35	exhaustion	exhaustion	NOUN
aji-177	294	36	,	,	PUNCT
aji-177	294	37	ultimately	ultimately	ADV
aji-177	294	38	resulting	result	VERB
aji-177	294	39	in	in	ADP
aji-177	294	40	icb	icb	PROPN
aji-177	294	41	resistance	resistance	NOUN
aji-177	294	42	.	.	PUNCT
aji-177	295	1	this	this	DET
aji-177	295	2	paradigm	paradigm	NOUN
aji-177	295	3	shift	shift	NOUN
aji-177	295	4	from	from	ADP
aji-177	295	5	viewing	view	VERB
aji-177	295	6	the	the	DET
aji-177	295	7	microbiome	microbiome	NOUN
aji-177	295	8	as	as	ADP
aji-177	295	9	a	a	DET
aji-177	295	10	simple	simple	ADJ
aji-177	295	11	correlate	correlate	NOUN
aji-177	295	12	to	to	ADP
aji-177	295	13	understanding	understand	VERB
aji-177	295	14	it	it	PRON
aji-177	295	15	as	as	ADP
aji-177	295	16	an	an	DET
aji-177	295	17	active	active	ADJ
aji-177	295	18	modulator	modulator	NOUN
aji-177	295	19	of	of	ADP
aji-177	295	20	specific	specific	ADJ
aji-177	295	21	innate	innate	ADJ
aji-177	295	22	immune	immune	ADJ
aji-177	295	23	effector	effector	NOUN
aji-177	295	24	mechanisms	mechanism	NOUN
aji-177	295	25	like	like	ADP
aji-177	295	26	netosis	netosis	NOUN
aji-177	295	27	has	have	VERB
aji-177	295	28	significant	significant	ADJ
aji-177	295	29	implications	implication	NOUN
aji-177	295	30	.	.	PUNCT
aji-177	296	1	it	it	PRON
aji-177	296	2	moves	move	VERB
aji-177	296	3	the	the	DET
aji-177	296	4	field	field	NOUN
aji-177	296	5	beyond	beyond	ADP
aji-177	296	6	taxonomic	taxonomic	ADJ
aji-177	296	7	associations	association	NOUN
aji-177	296	8	and	and	CCONJ
aji-177	296	9	towards	towards	ADP
aji-177	296	10	a	a	DET
aji-177	296	11	functional	functional	ADJ
aji-177	296	12	,	,	PUNCT
aji-177	296	13	metabolite	metabolite	NOUN
aji-177	296	14	-	-	PUNCT
aji-177	296	15	driven	drive	VERB
aji-177	296	16	understanding	understanding	NOUN
aji-177	296	17	of	of	ADP
aji-177	296	18	therapy	therapy	NOUN
aji-177	296	19	response	response	NOUN
aji-177	296	20	.	.	PUNCT
aji-177	297	1	the	the	DET
aji-177	297	2	axis	axis	NOUN
aji-177	297	3	provides	provide	VERB
aji-177	297	4	a	a	DET
aji-177	297	5	unifying	unifying	ADJ
aji-177	297	6	explanation	explanation	NOUN
aji-177	297	7	for	for	ADP
aji-177	297	8	how	how	SCONJ
aji-177	297	9	a	a	DET
aji-177	297	10	distal	distal	ADJ
aji-177	297	11	community	community	NOUN
aji-177	297	12	of	of	ADP
aji-177	297	13	microbes	microbe	NOUN
aji-177	297	14	can	can	AUX
aji-177	297	15	precisely	precisely	ADV
aji-177	297	16	tune	tune	VERB
aji-177	297	17	the	the	DET
aji-177	297	18	immune	immune	ADJ
aji-177	297	19	landscape	landscape	NOUN
aji-177	297	20	of	of	ADP
aji-177	297	21	a	a	DET
aji-177	297	22	distant	distant	ADJ
aji-177	297	23	tumor	tumor	NOUN
aji-177	297	24	.	.	PUNCT
aji-177	298	1	looking	look	VERB
aji-177	298	2	forward	forward	ADV
aji-177	298	3	,	,	PUNCT
aji-177	298	4	this	this	DET
aji-177	298	5	knowledge	knowledge	NOUN
aji-177	298	6	opens	open	VERB
aji-177	298	7	up	up	ADP
aji-177	298	8	a	a	DET
aji-177	298	9	promising	promising	ADJ
aji-177	298	10	frontier	frontier	NOUN
aji-177	298	11	for	for	ADP
aji-177	298	12	clinical	clinical	ADJ
aji-177	298	13	translation	translation	NOUN
aji-177	298	14	.	.	PUNCT
aji-177	299	1	the	the	DET
aji-177	299	2	gut	gut	PROPN
aji-177	299	3	jimoh	jimoh	PROPN
aji-177	299	4	et	et	PROPN
aji-177	299	5	al	al	PROPN
aji-177	299	6	.	.	PROPN
aji-177	299	7	;	;	PUNCT
aji-177	299	8	asian	asian	PROPN
aji-177	299	9	j.	j.	PROPN
aji-177	299	10	immunol	immunol	PROPN
aji-177	299	11	.	.	PROPN
aji-177	299	12	,	,	PUNCT
aji-177	299	13	vol	vol	NOUN
aji-177	299	14	.	.	PROPN
aji-177	299	15	8	8	NUM
aji-177	299	16	,	,	PUNCT
aji-177	299	17	no	no	INTJ
aji-177	299	18	.	.	NOUN
aji-177	299	19	1	1	NUM
aji-177	299	20	,	,	PUNCT
aji-177	299	21	pp	pp	ADJ
aji-177	299	22	.	.	PUNCT
aji-177	300	1	257	257	NUM
aji-177	300	2	-	-	SYM
aji-177	300	3	268	268	NUM
aji-177	300	4	,	,	PUNCT
aji-177	300	5	2025	2025	NUM
aji-177	300	6	;	;	PUNCT
aji-177	300	7	article	article	NOUN
aji-177	300	8	no.aji.147982	no.aji.147982	VERB
aji-177	300	9	266	266	NUM
aji-177	300	10	net	net	NOUN
aji-177	300	11	-	-	PUNCT
aji-177	300	12	icb	icb	PROPN
aji-177	300	13	axis	axis	NOUN
aji-177	300	14	is	be	AUX
aji-177	300	15	not	not	PART
aji-177	300	16	merely	merely	ADV
aji-177	300	17	a	a	DET
aji-177	300	18	explanatory	explanatory	ADJ
aji-177	300	19	model	model	NOUN
aji-177	300	20	;	;	PUNCT
aji-177	300	21	it	it	PRON
aji-177	300	22	is	be	AUX
aji-177	300	23	a	a	DET
aji-177	300	24	roadmap	roadmap	NOUN
aji-177	300	25	for	for	ADP
aji-177	300	26	therapeutic	therapeutic	ADJ
aji-177	300	27	innovation	innovation	NOUN
aji-177	300	28	.	.	PUNCT
aji-177	301	1	strategies	strategy	NOUN
aji-177	301	2	targeting	target	VERB
aji-177	301	3	the	the	DET
aji-177	301	4	gut	gut	NOUN
aji-177	301	5	microbiome	microbiome	NOUN
aji-177	301	6	,	,	PUNCT
aji-177	301	7	its	its	PRON
aji-177	301	8	metabolic	metabolic	NOUN
aji-177	301	9	output	output	NOUN
aji-177	301	10	(	(	PUNCT
aji-177	301	11	postbiotics	postbiotic	NOUN
aji-177	301	12	)	)	PUNCT
aji-177	301	13	,	,	PUNCT
aji-177	301	14	or	or	CCONJ
aji-177	301	15	the	the	DET
aji-177	301	16	downstream	downstream	ADJ
aji-177	301	17	netotic	netotic	ADJ
aji-177	301	18	process	process	NOUN
aji-177	301	19	itself	itself	PRON
aji-177	301	20	(	(	PUNCT
aji-177	301	21	pad4	pad4	NOUN
aji-177	301	22	inhibitors	inhibitor	NOUN
aji-177	301	23	,	,	PUNCT
aji-177	301	24	dnase	dnase	PROPN
aji-177	301	25	)	)	PUNCT
aji-177	301	26	represent	represent	VERB
aji-177	301	27	tangible	tangible	ADJ
aji-177	301	28	,	,	PUNCT
aji-177	301	29	combinatorial	combinatorial	ADJ
aji-177	301	30	approaches	approach	NOUN
aji-177	301	31	to	to	PART
aji-177	301	32	overcome	overcome	VERB
aji-177	301	33	immunotherapy	immunotherapy	NOUN
aji-177	301	34	resistance	resistance	NOUN
aji-177	301	35	.	.	PUNCT
aji-177	302	1	future	future	ADJ
aji-177	302	2	research	research	NOUN
aji-177	302	3	must	must	AUX
aji-177	302	4	focus	focus	VERB
aji-177	302	5	on	on	ADP
aji-177	302	6	validating	validate	VERB
aji-177	302	7	these	these	DET
aji-177	302	8	mechanistic	mechanistic	ADJ
aji-177	302	9	links	link	NOUN
aji-177	302	10	in	in	ADP
aji-177	302	11	human	human	ADJ
aji-177	302	12	cohorts	cohort	NOUN
aji-177	302	13	,	,	PUNCT
aji-177	302	14	identifying	identify	VERB
aji-177	302	15	predictive	predictive	ADJ
aji-177	302	16	metabolite	metabolite	NOUN
aji-177	302	17	and	and	CCONJ
aji-177	302	18	net	net	NOUN
aji-177	302	19	-	-	PUNCT
aji-177	302	20	based	base	VERB
aji-177	302	21	biomarkers	biomarker	NOUN
aji-177	302	22	,	,	PUNCT
aji-177	302	23	and	and	CCONJ
aji-177	302	24	launching	launch	VERB
aji-177	302	25	clinical	clinical	ADJ
aji-177	302	26	trials	trial	NOUN
aji-177	302	27	that	that	PRON
aji-177	302	28	strategically	strategically	ADV
aji-177	302	29	manipulate	manipulate	VERB
aji-177	302	30	this	this	DET
aji-177	302	31	axis	axis	NOUN
aji-177	302	32	.	.	PUNCT
aji-177	303	1	by	by	ADP
aji-177	303	2	harnessing	harness	VERB
aji-177	303	3	the	the	DET
aji-177	303	4	power	power	NOUN
aji-177	303	5	of	of	ADP
aji-177	303	6	the	the	DET
aji-177	303	7	gut	gut	NOUN
aji-177	303	8	microbiome	microbiome	NOUN
aji-177	303	9	to	to	PART
aji-177	303	10	disarm	disarm	VERB
aji-177	303	11	a	a	DET
aji-177	303	12	key	key	ADJ
aji-177	303	13	mechanism	mechanism	NOUN
aji-177	303	14	of	of	ADP
aji-177	303	15	immunosuppression	immunosuppression	NOUN
aji-177	303	16	,	,	PUNCT
aji-177	303	17	we	we	PRON
aji-177	303	18	can	can	AUX
aji-177	303	19	ultimately	ultimately	ADV
aji-177	303	20	expand	expand	VERB
aji-177	303	21	the	the	DET
aji-177	303	22	reach	reach	NOUN
aji-177	303	23	and	and	CCONJ
aji-177	303	24	success	success	NOUN
aji-177	303	25	of	of	ADP
aji-177	303	26	cancer	cancer	NOUN
aji-177	303	27	immunotherapy	immunotherapy	NOUN
aji-177	303	28	for	for	ADP
aji-177	303	29	a	a	DET
aji-177	303	30	greater	great	ADJ
aji-177	303	31	number	number	NOUN
aji-177	303	32	of	of	ADP
aji-177	303	33	patients	patient	NOUN
aji-177	303	34	.	.	PUNCT
aji-177	304	1	5.1	5.1	NUM
aji-177	304	2	future	future	ADJ
aji-177	304	3	perspectives	perspective	NOUN
aji-177	304	4	the	the	DET
aji-177	304	5	elucidated	elucidated	ADJ
aji-177	304	6	gut	gut	NOUN
aji-177	304	7	-	-	PUNCT
aji-177	304	8	net	net	NOUN
aji-177	304	9	-	-	PUNCT
aji-177	304	10	icb	icb	PROPN
aji-177	304	11	axis	axis	NOUN
aji-177	304	12	provides	provide	VERB
aji-177	304	13	a	a	DET
aji-177	304	14	powerful	powerful	ADJ
aji-177	304	15	,	,	PUNCT
aji-177	304	16	mechanistic	mechanistic	ADJ
aji-177	304	17	framework	framework	NOUN
aji-177	304	18	that	that	PRON
aji-177	304	19	connects	connect	VERB
aji-177	304	20	the	the	DET
aji-177	304	21	gut	gut	NOUN
aji-177	304	22	microbiome	microbiome	NOUN
aji-177	304	23	's	's	PART
aji-177	304	24	metabolic	metabolic	NOUN
aji-177	304	25	output	output	NOUN
aji-177	304	26	to	to	ADP
aji-177	304	27	a	a	DET
aji-177	304	28	specific	specific	ADJ
aji-177	304	29	innate	innate	ADJ
aji-177	304	30	immune	immune	ADJ
aji-177	304	31	process	process	NOUN
aji-177	304	32	,	,	PUNCT
aji-177	304	33	netosis	netosis	PROPN
aji-177	304	34	,	,	PUNCT
aji-177	304	35	which	which	PRON
aji-177	304	36	critically	critically	ADV
aji-177	304	37	determines	determine	VERB
aji-177	304	38	the	the	DET
aji-177	304	39	efficacy	efficacy	NOUN
aji-177	304	40	of	of	ADP
aji-177	304	41	adaptive	adaptive	ADJ
aji-177	304	42	immunotherapy	immunotherapy	NOUN
aji-177	304	43	.	.	PUNCT
aji-177	305	1	this	this	DET
aji-177	305	2	model	model	NOUN
aji-177	305	3	not	not	PART
aji-177	305	4	only	only	ADV
aji-177	305	5	deepens	deepen	VERB
aji-177	305	6	our	our	PRON
aji-177	305	7	fundamental	fundamental	ADJ
aji-177	305	8	understanding	understanding	NOUN
aji-177	305	9	of	of	ADP
aji-177	305	10	icb	icb	PROPN
aji-177	305	11	resistance	resistance	NOUN
aji-177	305	12	but	but	CCONJ
aji-177	305	13	also	also	ADV
aji-177	305	14	unveils	unveil	VERB
aji-177	305	15	a	a	DET
aji-177	305	16	suite	suite	NOUN
aji-177	305	17	of	of	ADP
aji-177	305	18	novel	novel	NOUN
aji-177	305	19	,	,	PUNCT
aji-177	305	20	actionable	actionable	ADJ
aji-177	305	21	strategies	strategy	NOUN
aji-177	305	22	to	to	PART
aji-177	305	23	improve	improve	VERB
aji-177	305	24	clinical	clinical	ADJ
aji-177	305	25	outcomes	outcome	NOUN
aji-177	305	26	.	.	PUNCT
aji-177	306	1	based	base	VERB
aji-177	306	2	on	on	ADP
aji-177	306	3	the	the	DET
aji-177	306	4	evidence	evidence	NOUN
aji-177	306	5	synthesized	synthesize	VERB
aji-177	306	6	in	in	ADP
aji-177	306	7	this	this	DET
aji-177	306	8	review	review	NOUN
aji-177	306	9	,	,	PUNCT
aji-177	306	10	we	we	PRON
aji-177	306	11	put	put	VERB
aji-177	306	12	forth	forth	ADP
aji-177	306	13	the	the	DET
aji-177	306	14	following	follow	VERB
aji-177	306	15	recommendations	recommendation	NOUN
aji-177	306	16	for	for	ADP
aji-177	306	17	future	future	ADJ
aji-177	306	18	research	research	NOUN
aji-177	306	19	and	and	CCONJ
aji-177	306	20	clinical	clinical	ADJ
aji-177	306	21	translation	translation	NOUN
aji-177	306	22	:	:	PUNCT
aji-177	306	23	1	1	X
aji-177	306	24	.	.	PUNCT
aji-177	306	25	prioritize	prioritize	VERB
aji-177	306	26	functional	functional	ADJ
aji-177	306	27	metabolomics	metabolomic	NOUN
aji-177	306	28	in	in	ADP
aji-177	306	29	clinical	clinical	ADJ
aji-177	306	30	cohorts	cohort	NOUN
aji-177	306	31	:	:	PUNCT
aji-177	306	32	future	future	ADJ
aji-177	306	33	clinical	clinical	ADJ
aji-177	306	34	studies	study	NOUN
aji-177	306	35	correlating	correlate	VERB
aji-177	306	36	the	the	DET
aji-177	306	37	microbiome	microbiome	NOUN
aji-177	306	38	with	with	ADP
aji-177	306	39	icb	icb	PROPN
aji-177	306	40	response	response	NOUN
aji-177	306	41	must	must	AUX
aji-177	306	42	move	move	VERB
aji-177	306	43	beyond	beyond	ADP
aji-177	306	44	16s	16s	X
aji-177	306	45	rrna	rrna	NOUN
aji-177	306	46	sequencing	sequence	VERB
aji-177	306	47	and	and	CCONJ
aji-177	306	48	integrate	integrate	VERB
aji-177	306	49	deep	deep	ADJ
aji-177	306	50	metagenomics	metagenomic	NOUN
aji-177	306	51	with	with	ADP
aji-177	306	52	metabolomic	metabolomic	ADJ
aji-177	306	53	profiling	profiling	NOUN
aji-177	306	54	of	of	ADP
aji-177	306	55	patient	patient	ADJ
aji-177	306	56	serum	serum	NOUN
aji-177	306	57	and	and	CCONJ
aji-177	306	58	feces	fece	NOUN
aji-177	306	59	.	.	PUNCT
aji-177	307	1	the	the	DET
aji-177	307	2	primary	primary	ADJ
aji-177	307	3	goal	goal	NOUN
aji-177	307	4	should	should	AUX
aji-177	307	5	be	be	AUX
aji-177	307	6	to	to	PART
aji-177	307	7	define	define	VERB
aji-177	307	8	a	a	DET
aji-177	307	9	"	"	PUNCT
aji-177	307	10	netosis	netosis	NOUN
aji-177	307	11	-	-	PUNCT
aji-177	307	12	suppressive	suppressive	ADJ
aji-177	307	13	metabolite	metabolite	NOUN
aji-177	307	14	signature	signature	NOUN
aji-177	307	15	"	"	PUNCT
aji-177	307	16	that	that	PRON
aji-177	307	17	can	can	AUX
aji-177	307	18	serve	serve	VERB
aji-177	307	19	as	as	ADP
aji-177	307	20	a	a	DET
aji-177	307	21	superior	superior	ADJ
aji-177	307	22	predictive	predictive	ADJ
aji-177	307	23	biomarker	biomarker	NOUN
aji-177	307	24	compared	compare	VERB
aji-177	307	25	to	to	ADP
aji-177	307	26	taxonomic	taxonomic	ADJ
aji-177	307	27	data	datum	NOUN
aji-177	307	28	alone	alone	ADV
aji-177	307	29	.	.	PUNCT
aji-177	308	1	2	2	X
aji-177	308	2	.	.	AUX
aji-177	308	3	establish	establish	VERB
aji-177	308	4	causality	causality	NOUN
aji-177	308	5	in	in	ADP
aji-177	308	6	gnotobiotic	gnotobiotic	ADJ
aji-177	308	7	models	model	NOUN
aji-177	308	8	:	:	PUNCT
aji-177	308	9	to	to	PART
aji-177	308	10	move	move	VERB
aji-177	308	11	from	from	ADP
aji-177	308	12	correlation	correlation	NOUN
aji-177	308	13	to	to	ADP
aji-177	308	14	causation	causation	NOUN
aji-177	308	15	,	,	PUNCT
aji-177	308	16	welldefined	welldefine	VERB
aji-177	308	17	gnotobiotic	gnotobiotic	ADJ
aji-177	308	18	mouse	mouse	NOUN
aji-177	308	19	models	model	NOUN
aji-177	308	20	should	should	AUX
aji-177	308	21	be	be	AUX
aji-177	308	22	employed	employ	VERB
aji-177	308	23	.	.	PUNCT
aji-177	309	1	colonizing	colonize	VERB
aji-177	309	2	germ	germ	NOUN
aji-177	309	3	-	-	PUNCT
aji-177	309	4	free	free	ADJ
aji-177	309	5	mice	mouse	NOUN
aji-177	309	6	with	with	ADP
aji-177	309	7	consortia	consortium	NOUN
aji-177	309	8	of	of	ADP
aji-177	309	9	bacteria	bacteria	NOUN
aji-177	309	10	engineered	engineer	VERB
aji-177	309	11	to	to	PART
aji-177	309	12	produce	produce	VERB
aji-177	309	13	specific	specific	ADJ
aji-177	309	14	metabolites	metabolite	NOUN
aji-177	309	15	(	(	PUNCT
aji-177	309	16	e.g.	e.g.	ADJ
aji-177	309	17	,	,	PUNCT
aji-177	309	18	scfa	scfa	NOUN
aji-177	309	19	-	-	PUNCT
aji-177	309	20	producers	producer	NOUN
aji-177	309	21	versus	versus	ADP
aji-177	309	22	non	non	ADJ
aji-177	309	23	-	-	NOUN
aji-177	309	24	producers	producer	NOUN
aji-177	309	25	)	)	PUNCT
aji-177	309	26	and	and	CCONJ
aji-177	309	27	subjecting	subject	VERB
aji-177	309	28	them	they	PRON
aji-177	309	29	to	to	ADP
aji-177	309	30	icb	icb	PROPN
aji-177	309	31	and	and	CCONJ
aji-177	309	32	netosis	netosis	NOUN
aji-177	309	33	assays	assay	NOUN
aji-177	309	34	will	will	AUX
aji-177	309	35	provide	provide	VERB
aji-177	309	36	direct	direct	ADJ
aji-177	309	37	proof	proof	NOUN
aji-177	309	38	of	of	ADP
aji-177	309	39	the	the	DET
aji-177	309	40	metabolite	metabolite	NOUN
aji-177	309	41	-	-	PUNCT
aji-177	309	42	net	net	NOUN
aji-177	309	43	link	link	NOUN
aji-177	309	44	.	.	PUNCT
aji-177	310	1	3	3	X
aji-177	310	2	.	.	X
aji-177	310	3	explore	explore	VERB
aji-177	310	4	combinatorial	combinatorial	ADJ
aji-177	310	5	clinical	clinical	ADJ
aji-177	310	6	trials	trial	NOUN
aji-177	310	7	:	:	PUNCT
aji-177	310	8	the	the	DET
aji-177	310	9	most	most	ADV
aji-177	310	10	immediate	immediate	ADJ
aji-177	310	11	translational	translational	ADJ
aji-177	310	12	path	path	NOUN
aji-177	310	13	involves	involve	VERB
aji-177	310	14	designing	design	VERB
aji-177	310	15	clinical	clinical	ADJ
aji-177	310	16	trials	trial	NOUN
aji-177	310	17	that	that	PRON
aji-177	310	18	combine	combine	VERB
aji-177	310	19	icb	icb	PROPN
aji-177	310	20	with	with	ADP
aji-177	310	21	interventions	intervention	NOUN
aji-177	310	22	targeting	target	VERB
aji-177	310	23	the	the	DET
aji-177	310	24	gut	gut	NOUN
aji-177	310	25	-	-	PUNCT
aji-177	310	26	net	net	NOUN
aji-177	310	27	axis	axis	NOUN
aji-177	310	28	.	.	PUNCT
aji-177	311	1	we	we	PRON
aji-177	311	2	recommend	recommend	VERB
aji-177	311	3	prioritizing	prioritize	VERB
aji-177	311	4	:	:	PUNCT
aji-177	311	5	icb	icb	PROPN
aji-177	311	6	+	+	CCONJ
aji-177	311	7	pre	pre	ADJ
aji-177	311	8	/	/	NOUN
aji-177	311	9	postbiotics	postbiotic	NOUN
aji-177	311	10	:	:	PUNCT
aji-177	311	11	testing	test	VERB
aji-177	311	12	high	high	ADJ
aji-177	311	13	-	-	PUNCT
aji-177	311	14	fiber	fiber	NOUN
aji-177	311	15	diets	diet	NOUN
aji-177	311	16	or	or	CCONJ
aji-177	311	17	scfa	scfa	NOUN
aji-177	311	18	/	/	SYM
aji-177	311	19	spermidine	spermidine	NOUN
aji-177	311	20	supplements	supplement	NOUN
aji-177	311	21	in	in	ADP
aji-177	311	22	conjunction	conjunction	NOUN
aji-177	311	23	with	with	ADP
aji-177	311	24	anti	anti	ADJ
aji-177	311	25	-	-	ADJ
aji-177	311	26	pd-1	pd-1	ADJ
aji-177	311	27	therapy	therapy	NOUN
aji-177	311	28	.	.	PUNCT
aji-177	312	1	icb	icb	PROPN
aji-177	313	1	+	+	CCONJ
aji-177	313	2	netosis	netosis	NOUN
aji-177	313	3	inhibition	inhibition	NOUN
aji-177	313	4	:	:	PUNCT
aji-177	313	5	investigating	investigate	VERB
aji-177	313	6	the	the	DET
aji-177	313	7	safety	safety	NOUN
aji-177	313	8	and	and	CCONJ
aji-177	313	9	efficacy	efficacy	NOUN
aji-177	313	10	of	of	ADP
aji-177	313	11	pad4	pad4	NOUN
aji-177	313	12	inhibitors	inhibitor	NOUN
aji-177	313	13	or	or	CCONJ
aji-177	313	14	dnase	dnase	VERB
aji-177	313	15	i	i	PRON
aji-177	313	16	in	in	ADP
aji-177	313	17	overcoming	overcome	VERB
aji-177	313	18	resistance	resistance	NOUN
aji-177	313	19	in	in	ADP
aji-177	313	20	selected	select	VERB
aji-177	313	21	cancer	cancer	NOUN
aji-177	313	22	types	type	NOUN
aji-177	313	23	.	.	PUNCT
aji-177	314	1	4	4	X
aji-177	314	2	.	.	X
aji-177	314	3	develop	develop	VERB
aji-177	314	4	standardized	standardized	ADJ
aji-177	314	5	net	net	ADJ
aji-177	314	6	biomarkers	biomarker	NOUN
aji-177	314	7	:	:	PUNCT
aji-177	314	8	the	the	DET
aji-177	314	9	field	field	NOUN
aji-177	314	10	requires	require	VERB
aji-177	314	11	a	a	DET
aji-177	314	12	concerted	concerted	ADJ
aji-177	314	13	effort	effort	NOUN
aji-177	314	14	to	to	PART
aji-177	314	15	standardize	standardize	VERB
aji-177	314	16	the	the	DET
aji-177	314	17	measurement	measurement	NOUN
aji-177	314	18	of	of	ADP
aji-177	314	19	nets	net	NOUN
aji-177	314	20	in	in	ADP
aji-177	314	21	human	human	ADJ
aji-177	314	22	samples	sample	NOUN
aji-177	314	23	.	.	PUNCT
aji-177	315	1	validated	validate	VERB
aji-177	315	2	assays	assay	NOUN
aji-177	315	3	for	for	ADP
aji-177	315	4	circulating	circulate	VERB
aji-177	315	5	net	net	ADJ
aji-177	315	6	remnants	remnant	NOUN
aji-177	315	7	are	be	AUX
aji-177	315	8	needed	need	VERB
aji-177	315	9	to	to	PART
aji-177	315	10	correlate	correlate	VERB
aji-177	315	11	systemic	systemic	ADJ
aji-177	315	12	net	net	ADJ
aji-177	315	13	load	load	NOUN
aji-177	315	14	with	with	ADP
aji-177	315	15	metabolite	metabolite	NOUN
aji-177	315	16	levels	level	NOUN
aji-177	315	17	and	and	CCONJ
aji-177	315	18	icb	icb	VERB
aji-177	315	19	response	response	NOUN
aji-177	315	20	in	in	ADP
aji-177	315	21	patient	patient	ADJ
aji-177	315	22	cohorts	cohort	NOUN
aji-177	315	23	.	.	PUNCT
aji-177	316	1	5	5	X
aji-177	316	2	.	.	X
aji-177	316	3	personalize	personalize	VERB
aji-177	316	4	microbiome	microbiome	NOUN
aji-177	316	5	-	-	PUNCT
aji-177	316	6	modulating	modulate	VERB
aji-177	316	7	therapies	therapy	NOUN
aji-177	316	8	:	:	PUNCT
aji-177	316	9	recognizing	recognize	VERB
aji-177	316	10	that	that	SCONJ
aji-177	316	11	a	a	DET
aji-177	316	12	"	"	PUNCT
aji-177	316	13	one	one	NUM
aji-177	316	14	-	-	PUNCT
aji-177	316	15	size	size	NOUN
aji-177	316	16	-	-	PUNCT
aji-177	316	17	fits	fit	VERB
aji-177	316	18	-	-	PUNCT
aji-177	316	19	all	all	PRON
aji-177	316	20	"	"	PUNCT
aji-177	316	21	microbiome	microbiome	ADJ
aji-177	316	22	intervention	intervention	NOUN
aji-177	316	23	may	may	AUX
aji-177	316	24	be	be	AUX
aji-177	316	25	ineffective	ineffective	ADJ
aji-177	316	26	,	,	PUNCT
aji-177	316	27	we	we	PRON
aji-177	316	28	recommend	recommend	VERB
aji-177	316	29	developing	develop	VERB
aji-177	316	30	diagnostic	diagnostic	ADJ
aji-177	316	31	platforms	platform	NOUN
aji-177	316	32	to	to	PART
aji-177	316	33	match	match	VERB
aji-177	316	34	patients	patient	NOUN
aji-177	316	35	with	with	ADP
aji-177	316	36	dysbiotic	dysbiotic	ADJ
aji-177	316	37	,	,	PUNCT
aji-177	316	38	netosis	netosis	NOUN
aji-177	316	39	-	-	PUNCT
aji-177	316	40	promoting	promote	VERB
aji-177	316	41	profiles	profile	NOUN
aji-177	316	42	to	to	PART
aji-177	316	43	tailored	tailor	VERB
aji-177	316	44	interventional	interventional	ADJ
aji-177	316	45	strategies	strategy	NOUN
aji-177	316	46	,	,	PUNCT
aji-177	316	47	such	such	ADJ
aji-177	316	48	as	as	ADP
aji-177	316	49	fmt	fmt	VERB
aji-177	316	50	from	from	ADP
aji-177	316	51	donors	donor	NOUN
aji-177	316	52	with	with	ADP
aji-177	316	53	a	a	DET
aji-177	316	54	validated	validate	VERB
aji-177	316	55	beneficial	beneficial	ADJ
aji-177	316	56	metabolome	metabolome	NOUN
aji-177	316	57	.	.	PUNCT
aji-177	317	1	disclaimer	disclaimer	PROPN
aji-177	317	2	(	(	PUNCT
aji-177	317	3	artificial	artificial	ADJ
aji-177	317	4	intelligence	intelligence	NOUN
aji-177	317	5	)	)	PUNCT
aji-177	317	6	author(s	author(s	NOUN
aji-177	317	7	)	)	PUNCT
aji-177	317	8	hereby	hereby	ADV
aji-177	317	9	declare	declare	VERB
aji-177	317	10	that	that	SCONJ
aji-177	317	11	no	no	DET
aji-177	317	12	generative	generative	NOUN
aji-177	317	13	ai	ai	VERB
aji-177	317	14	technologies	technology	NOUN
aji-177	317	15	such	such	ADJ
aji-177	317	16	as	as	ADP
aji-177	317	17	large	large	ADJ
aji-177	317	18	language	language	NOUN
aji-177	317	19	models	model	NOUN
aji-177	317	20	(	(	PUNCT
aji-177	317	21	chatgpt	chatgpt	NOUN
aji-177	317	22	,	,	PUNCT
aji-177	317	23	copilot	copilot	NOUN
aji-177	317	24	,	,	PUNCT
aji-177	317	25	etc	etc	X
aji-177	317	26	)	)	PUNCT
aji-177	317	27	and	and	CCONJ
aji-177	317	28	text	text	NOUN
aji-177	317	29	-	-	PUNCT
aji-177	317	30	to	to	ADP
aji-177	317	31	-	-	PUNCT
aji-177	317	32	image	image	NOUN
aji-177	317	33	generators	generator	NOUN
aji-177	317	34	have	have	AUX
aji-177	317	35	been	be	AUX
aji-177	317	36	used	use	VERB
aji-177	317	37	during	during	ADP
aji-177	317	38	writing	writing	NOUN
aji-177	317	39	or	or	CCONJ
aji-177	317	40	editing	editing	NOUN
aji-177	317	41	of	of	ADP
aji-177	317	42	this	this	DET
aji-177	317	43	manuscript	manuscript	NOUN
aji-177	317	44	.	.	PUNCT
aji-177	318	1	consent	consent	NOUN
aji-177	318	2	and	and	CCONJ
aji-177	318	3	ethical	ethical	ADJ
aji-177	318	4	approval	approval	NOUN
aji-177	318	5	it	it	PRON
aji-177	318	6	is	be	AUX
aji-177	318	7	not	not	PART
aji-177	318	8	applicable	applicable	ADJ
aji-177	318	9	.	.	PUNCT
aji-177	319	1	competing	compete	VERB
aji-177	319	2	interests	interest	NOUN
aji-177	319	3	authors	author	NOUN
aji-177	319	4	have	have	AUX
aji-177	319	5	declared	declare	VERB
aji-177	319	6	that	that	SCONJ
aji-177	319	7	no	no	DET
aji-177	319	8	competing	compete	VERB
aji-177	319	9	interests	interest	NOUN
aji-177	319	10	exist	exist	VERB
aji-177	319	11	.	.	PUNCT
aji-177	320	1	references	reference	NOUN
aji-177	320	2	ajibola	ajibola	PROPN
aji-177	320	3	,	,	PUNCT
aji-177	320	4	f.	f.	PROPN
aji-177	320	5	o.	o.	PROPN
aji-177	320	6	,	,	PUNCT
aji-177	320	7	&	&	CCONJ
aji-177	320	8	ayodele	ayodele	PROPN
aji-177	320	9	,	,	PUNCT
aji-177	320	10	a.	a.	PROPN
aji-177	320	11	e.	e.	PROPN
aji-177	320	12	(	(	PUNCT
aji-177	320	13	2025	2025	NUM
aji-177	320	14	)	)	PUNCT
aji-177	320	15	.	.	PUNCT
aji-177	321	1	epigenetic	epigenetic	ADJ
aji-177	321	2	dysregulation	dysregulation	NOUN
aji-177	321	3	and	and	CCONJ
aji-177	321	4	its	its	PRON
aji-177	321	5	role	role	NOUN
aji-177	321	6	in	in	ADP
aji-177	321	7	immune	immune	NOUN
aji-177	321	8	-	-	PUNCT
aji-177	321	9	mediated	mediate	VERB
aji-177	321	10	diseases	disease	NOUN
aji-177	321	11	.	.	PUNCT
aji-177	322	1	asian	asian	ADJ
aji-177	322	2	journal	journal	NOUN
aji-177	322	3	of	of	ADP
aji-177	322	4	immunology	immunology	NOUN
aji-177	322	5	,	,	PUNCT
aji-177	322	6	8(1	8(1	NOUN
aji-177	322	7	)	)	PUNCT
aji-177	322	8	,	,	PUNCT
aji-177	322	9	230–241	230–241	NUM
aji-177	322	10	.	.	PUNCT
aji-177	323	1	https://doi.org/10.9734/aji/2025/v8i1174	https://doi.org/10.9734/aji/2025/v8i1174	PROPN
aji-177	323	2	ayodele	ayodele	PROPN
aji-177	323	3	,	,	PUNCT
aji-177	323	4	a.	a.	PROPN
aji-177	323	5	e.	e.	PROPN
aji-177	323	6	(	(	PUNCT
aji-177	323	7	2025	2025	NUM
aji-177	323	8	)	)	PUNCT
aji-177	323	9	.	.	PUNCT
aji-177	324	1	gut	gut	NOUN
aji-177	324	2	microbiota	microbiota	NOUN
aji-177	324	3	–	–	PUNCT
aji-177	324	4	immune	immune	ADJ
aji-177	324	5	system	system	NOUN
aji-177	324	6	cross	cross	NOUN
aji-177	324	7	-	-	ADJ
aji-177	324	8	talk	talk	ADJ
aji-177	324	9	:	:	PUNCT
aji-177	324	10	mechanisms	mechanism	NOUN
aji-177	324	11	of	of	ADP
aji-177	324	12	microbial	microbial	ADJ
aji-177	324	13	regulation	regulation	NOUN
aji-177	324	14	of	of	ADP
aji-177	324	15	host	host	NOUN
aji-177	324	16	immune	immune	ADJ
aji-177	324	17	responses	response	NOUN
aji-177	324	18	in	in	ADP
aji-177	324	19	health	health	NOUN
aji-177	324	20	and	and	CCONJ
aji-177	324	21	disease	disease	NOUN
aji-177	324	22	.	.	PUNCT
aji-177	325	1	https://doi.org/10.9734/aji/2025/v8i1174	https://doi.org/10.9734/aji/2025/v8i1174	PROPN
aji-177	325	2	jimoh	jimoh	PROPN
aji-177	325	3	et	et	PROPN
aji-177	325	4	al	al	PROPN
aji-177	325	5	.	.	PROPN
aji-177	325	6	;	;	PUNCT
aji-177	325	7	asian	asian	PROPN
aji-177	325	8	j.	j.	PROPN
aji-177	325	9	immunol	immunol	PROPN
aji-177	325	10	.	.	PROPN
aji-177	325	11	,	,	PUNCT
aji-177	325	12	vol	vol	NOUN
aji-177	325	13	.	.	PROPN
aji-177	325	14	8	8	NUM
aji-177	325	15	,	,	PUNCT
aji-177	325	16	no	no	INTJ
aji-177	325	17	.	.	NOUN
aji-177	325	18	1	1	NUM
aji-177	325	19	,	,	PUNCT
aji-177	325	20	pp	pp	ADJ
aji-177	325	21	.	.	PUNCT
aji-177	326	1	257	257	NUM
aji-177	326	2	-	-	SYM
aji-177	326	3	268	268	NUM
aji-177	326	4	,	,	PUNCT
aji-177	326	5	2025	2025	NUM
aji-177	326	6	;	;	PUNCT
aji-177	326	7	article	article	NOUN
aji-177	326	8	no.aji.147982	no.aji.147982	VERB
aji-177	326	9	267	267	NUM
aji-177	326	10	international	international	ADJ
aji-177	326	11	journal	journal	NOUN
aji-177	326	12	of	of	ADP
aji-177	326	13	scholarly	scholarly	ADJ
aji-177	326	14	resources	resource	NOUN
aji-177	326	15	,	,	PUNCT
aji-177	326	16	18(2	18(2	NUM
aji-177	326	17	)	)	PUNCT
aji-177	326	18	,	,	PUNCT
aji-177	327	1	93–112	93–112	PROPN
aji-177	327	2	.	.	PUNCT
aji-177	327	3	ayodele	ayodele	PROPN
aji-177	327	4	,	,	PUNCT
aji-177	327	5	a.	a.	PROPN
aji-177	327	6	e.	e.	PROPN
aji-177	327	7	,	,	PUNCT
aji-177	327	8	ugama	ugama	NOUN
aji-177	327	9	,	,	PUNCT
aji-177	327	10	p.	p.	PROPN
aji-177	327	11	c.	c.	PROPN
aji-177	327	12	,	,	PUNCT
aji-177	327	13	olatokun	olatokun	PROPN
aji-177	327	14	,	,	PUNCT
aji-177	327	15	t.	t.	PROPN
aji-177	327	16	p.	p.	PROPN
aji-177	327	17	,	,	PUNCT
aji-177	327	18	jimoh	jimoh	PROPN
aji-177	327	19	,	,	PUNCT
aji-177	327	20	i.	i.	PROPN
aji-177	327	21	a.	a.	PROPN
aji-177	327	22	,	,	PUNCT
aji-177	327	23	&	&	CCONJ
aji-177	327	24	oyebamiji	oyebamiji	PROPN
aji-177	327	25	,	,	PUNCT
aji-177	327	26	b.	b.	PROPN
aji-177	327	27	o.	o.	PROPN
aji-177	327	28	(	(	PUNCT
aji-177	327	29	2025	2025	NUM
aji-177	327	30	)	)	PUNCT
aji-177	327	31	.	.	PUNCT
aji-177	328	1	role	role	NOUN
aji-177	328	2	of	of	ADP
aji-177	328	3	gut	gut	ADJ
aji-177	328	4	microbiota	microbiota	NOUN
aji-177	328	5	-	-	PUNCT
aji-177	328	6	derived	derive	VERB
aji-177	328	7	metabolites	metabolite	NOUN
aji-177	328	8	in	in	ADP
aji-177	328	9	modulating	modulate	VERB
aji-177	328	10	immune	immune	ADJ
aji-177	328	11	responses	response	NOUN
aji-177	328	12	in	in	ADP
aji-177	328	13	colorectal	colorectal	ADJ
aji-177	328	14	cancer	cancer	NOUN
aji-177	328	15	.	.	PUNCT
aji-177	329	1	international	international	ADJ
aji-177	329	2	journal	journal	PROPN
aji-177	329	3	of	of	ADP
aji-177	329	4	pathogen	pathogen	PROPN
aji-177	329	5	research	research	NOUN
aji-177	329	6	,	,	PUNCT
aji-177	329	7	14(5	14(5	NUM
aji-177	329	8	)	)	PUNCT
aji-177	329	9	,	,	PUNCT
aji-177	329	10	154–160	154–160	NUM
aji-177	329	11	.	.	PUNCT
aji-177	330	1	bi	bi	PROPN
aji-177	330	2	,	,	PUNCT
aji-177	330	3	w.	w.	PROPN
aji-177	330	4	,	,	PUNCT
aji-177	330	5	li	li	PROPN
aji-177	330	6	,	,	PUNCT
aji-177	330	7	x.	x.	PROPN
aji-177	330	8	,	,	PUNCT
aji-177	330	9	jiang	jiang	PROPN
aji-177	330	10	,	,	PUNCT
aji-177	330	11	y.	y.	PROPN
aji-177	330	12	,	,	PUNCT
aji-177	330	13	gao	gao	PROPN
aji-177	330	14	,	,	PUNCT
aji-177	330	15	t.	t.	PROPN
aji-177	330	16	,	,	PUNCT
aji-177	330	17	zhao	zhao	PROPN
aji-177	330	18	,	,	PUNCT
aji-177	330	19	h.	h.	PROPN
aji-177	330	20	,	,	PUNCT
aji-177	330	21	han	han	PROPN
aji-177	330	22	,	,	PUNCT
aji-177	330	23	q.	q.	PROPN
aji-177	330	24	,	,	PUNCT
aji-177	330	25	&	&	CCONJ
aji-177	330	26	zhang	zhang	PROPN
aji-177	330	27	,	,	PUNCT
aji-177	330	28	j.	j.	PROPN
aji-177	330	29	(	(	PUNCT
aji-177	330	30	2025	2025	NUM
aji-177	330	31	)	)	PUNCT
aji-177	330	32	.	.	PUNCT
aji-177	331	1	tumor	tumor	NOUN
aji-177	331	2	-	-	PUNCT
aji-177	331	3	derived	derive	VERB
aji-177	331	4	exosomes	exosome	NOUN
aji-177	331	5	induce	induce	VERB
aji-177	331	6	neutrophil	neutrophil	ADJ
aji-177	331	7	infiltration	infiltration	NOUN
aji-177	331	8	and	and	CCONJ
aji-177	331	9	reprogramming	reprogramme	VERB
aji-177	331	10	to	to	PART
aji-177	331	11	promote	promote	VERB
aji-177	331	12	t	t	NOUN
aji-177	331	13	-	-	PUNCT
aji-177	331	14	cell	cell	NOUN
aji-177	331	15	exhaustion	exhaustion	NOUN
aji-177	331	16	in	in	ADP
aji-177	331	17	hepatocellular	hepatocellular	ADJ
aji-177	331	18	carcinoma	carcinoma	NOUN
aji-177	331	19	.	.	PUNCT
aji-177	332	1	theranostics	theranostic	NOUN
aji-177	332	2	,	,	PUNCT
aji-177	332	3	15(7	15(7	NUM
aji-177	332	4	)	)	PUNCT
aji-177	332	5	,	,	PUNCT
aji-177	332	6	2852	2852	NUM
aji-177	332	7	.	.	PUNCT
aji-177	333	1	cai	cai	X
aji-177	333	2	,	,	PUNCT
aji-177	333	3	x.	x.	PROPN
aji-177	333	4	,	,	PUNCT
aji-177	333	5	cho	cho	PROPN
aji-177	333	6	,	,	PUNCT
aji-177	333	7	j.	j.	PROPN
aji-177	333	8	y.	y.	PROPN
aji-177	333	9	,	,	PUNCT
aji-177	333	10	chen	chen	PROPN
aji-177	333	11	,	,	PUNCT
aji-177	333	12	l.	l.	PROPN
aji-177	333	13	,	,	PUNCT
aji-177	333	14	liu	liu	PROPN
aji-177	333	15	,	,	PUNCT
aji-177	333	16	y.	y.	PROPN
aji-177	333	17	,	,	PUNCT
aji-177	333	18	ji	ji	PROPN
aji-177	333	19	,	,	PUNCT
aji-177	333	20	f.	f.	PROPN
aji-177	333	21	,	,	PUNCT
aji-177	333	22	salgado	salgado	PROPN
aji-177	333	23	,	,	PUNCT
aji-177	333	24	k.	k.	PROPN
aji-177	333	25	,	,	PUNCT
aji-177	333	26	…	…	PUNCT
aji-177	333	27	xia	xia	PROPN
aji-177	333	28	,	,	PUNCT
aji-177	333	29	t.	t.	PROPN
aji-177	333	30	(	(	PUNCT
aji-177	333	31	2025	2025	NUM
aji-177	333	32	)	)	PUNCT
aji-177	333	33	.	.	PUNCT
aji-177	334	1	enriched	enrich	VERB
aji-177	334	2	pathways	pathway	NOUN
aji-177	334	3	in	in	ADP
aji-177	334	4	gut	gut	NOUN
aji-177	334	5	microbiome	microbiome	NOUN
aji-177	334	6	predict	predict	VERB
aji-177	334	7	response	response	NOUN
aji-177	334	8	to	to	ADP
aji-177	334	9	immune	immune	ADJ
aji-177	334	10	checkpoint	checkpoint	NOUN
aji-177	334	11	inhibitor	inhibitor	NOUN
aji-177	334	12	treatment	treatment	NOUN
aji-177	334	13	across	across	ADP
aji-177	334	14	demographic	demographic	ADJ
aji-177	334	15	regions	region	NOUN
aji-177	334	16	and	and	CCONJ
aji-177	334	17	various	various	ADJ
aji-177	334	18	cancer	cancer	NOUN
aji-177	334	19	types	type	NOUN
aji-177	334	20	.	.	PUNCT
aji-177	335	1	iscience	iscience	NOUN
aji-177	335	2	,	,	PUNCT
aji-177	335	3	28(4	28(4	NUM
aji-177	335	4	)	)	PUNCT
aji-177	335	5	.	.	PUNCT
aji-177	336	1	davar	davar	PROPN
aji-177	336	2	,	,	PUNCT
aji-177	336	3	d.	d.	PROPN
aji-177	336	4	,	,	PUNCT
aji-177	336	5	dzutsev	dzutsev	VERB
aji-177	336	6	,	,	PUNCT
aji-177	336	7	a.	a.	PROPN
aji-177	336	8	k.	k.	PROPN
aji-177	336	9	,	,	PUNCT
aji-177	336	10	mcculloch	mcculloch	PROPN
aji-177	336	11	,	,	PUNCT
aji-177	336	12	j.	j.	PROPN
aji-177	336	13	a.	a.	PROPN
aji-177	336	14	,	,	PUNCT
aji-177	336	15	rodrigues	rodrigues	PROPN
aji-177	336	16	,	,	PUNCT
aji-177	336	17	r.	r.	PROPN
aji-177	336	18	r.	r.	PROPN
aji-177	336	19	,	,	PUNCT
aji-177	336	20	chauvin	chauvin	PROPN
aji-177	336	21	,	,	PUNCT
aji-177	336	22	j.	j.	PROPN
aji-177	336	23	m.	m.	PROPN
aji-177	336	24	,	,	PUNCT
aji-177	336	25	morrison	morrison	PROPN
aji-177	336	26	,	,	PUNCT
aji-177	336	27	r.	r.	PROPN
aji-177	336	28	m.	m.	PROPN
aji-177	336	29	,	,	PUNCT
aji-177	336	30	…	…	PUNCT
aji-177	336	31	zarour	zarour	X
aji-177	336	32	,	,	PUNCT
aji-177	336	33	h.	h.	PROPN
aji-177	336	34	m.	m.	NOUN
aji-177	336	35	(	(	PUNCT
aji-177	336	36	2021	2021	NUM
aji-177	336	37	)	)	PUNCT
aji-177	336	38	.	.	PUNCT
aji-177	337	1	fecal	fecal	ADJ
aji-177	337	2	microbiota	microbiota	NOUN
aji-177	337	3	transplant	transplant	NOUN
aji-177	337	4	overcomes	overcome	VERB
aji-177	337	5	resistance	resistance	NOUN
aji-177	337	6	to	to	ADP
aji-177	337	7	anti	anti	ADJ
aji-177	337	8	–	–	PUNCT
aji-177	337	9	pd-1	pd-1	VERB
aji-177	337	10	therapy	therapy	NOUN
aji-177	337	11	in	in	ADP
aji-177	337	12	melanoma	melanoma	NOUN
aji-177	337	13	patients	patient	NOUN
aji-177	337	14	.	.	PUNCT
aji-177	338	1	science	science	NOUN
aji-177	338	2	,	,	PUNCT
aji-177	338	3	371(6529	371(6529	NUM
aji-177	338	4	)	)	PUNCT
aji-177	338	5	,	,	PUNCT
aji-177	338	6	595–602	595–602	NUM
aji-177	338	7	.	.	PUNCT
aji-177	338	8	deng	deng	PROPN
aji-177	338	9	,	,	PUNCT
aji-177	338	10	m.	m.	NOUN
aji-177	338	11	,	,	PUNCT
aji-177	338	12	li	li	PROPN
aji-177	338	13	,	,	PUNCT
aji-177	338	14	x.	x.	PROPN
aji-177	338	15	,	,	PUNCT
aji-177	338	16	wu	wu	PROPN
aji-177	338	17	,	,	PUNCT
aji-177	338	18	h.	h.	PROPN
aji-177	338	19	,	,	PUNCT
aji-177	338	20	xue	xue	PROPN
aji-177	338	21	,	,	PUNCT
aji-177	338	22	d.	d.	PROPN
aji-177	338	23	,	,	PUNCT
aji-177	338	24	wang	wang	PROPN
aji-177	338	25	,	,	PUNCT
aji-177	338	26	y	y	PROPN
aji-177	338	27	,	,	PUNCT
aji-177	338	28	guo	guo	PROPN
aji-177	338	29	,	,	PUNCT
aji-177	338	30	r.	r.	PROPN
aji-177	338	31	,	,	PUNCT
aji-177	338	32	…	…	PUNCT
aji-177	338	33	li	li	PROPN
aji-177	338	34	,	,	PUNCT
aji-177	338	35	h.	h.	PROPN
aji-177	338	36	(	(	PUNCT
aji-177	338	37	2025	2025	NUM
aji-177	338	38	)	)	PUNCT
aji-177	338	39	.	.	PUNCT
aji-177	339	1	the	the	DET
aji-177	339	2	current	current	ADJ
aji-177	339	3	status	status	NOUN
aji-177	339	4	and	and	CCONJ
aji-177	339	5	prospects	prospect	NOUN
aji-177	339	6	of	of	ADP
aji-177	339	7	gut	gut	NOUN
aji-177	339	8	microbiota	microbiota	NOUN
aji-177	339	9	combined	combine	VERB
aji-177	339	10	with	with	ADP
aji-177	339	11	pd-1	pd-1	ADP
aji-177	339	12	/	/	SYM
aji-177	339	13	pd	pd	ADJ
aji-177	339	14	-	-	PUNCT
aji-177	339	15	l1	l1	PROPN
aji-177	339	16	inhibitors	inhibitor	NOUN
aji-177	339	17	in	in	ADP
aji-177	339	18	the	the	DET
aji-177	339	19	treatment	treatment	NOUN
aji-177	339	20	of	of	ADP
aji-177	339	21	colorectal	colorectal	ADJ
aji-177	339	22	cancer	cancer	NOUN
aji-177	339	23	:	:	PUNCT
aji-177	339	24	a	a	DET
aji-177	339	25	review	review	NOUN
aji-177	339	26	.	.	PUNCT
aji-177	340	1	bmc	bmc	ADJ
aji-177	340	2	gastroenterology	gastroenterology	NOUN
aji-177	340	3	,	,	PUNCT
aji-177	340	4	25(1	25(1	NUM
aji-177	340	5	)	)	PUNCT
aji-177	340	6	,	,	PUNCT
aji-177	340	7	380	380	NUM
aji-177	340	8	.	.	PUNCT
aji-177	341	1	jia	jia	PROPN
aji-177	341	2	,	,	PUNCT
aji-177	341	3	w.	w.	PROPN
aji-177	341	4	,	,	PUNCT
aji-177	341	5	xie	xie	PROPN
aji-177	341	6	,	,	PUNCT
aji-177	341	7	g.	g.	PROPN
aji-177	341	8	,	,	PUNCT
aji-177	341	9	&	&	CCONJ
aji-177	341	10	jia	jia	PROPN
aji-177	341	11	,	,	PUNCT
aji-177	341	12	w.	w.	PROPN
aji-177	341	13	(	(	PUNCT
aji-177	341	14	2018	2018	NUM
aji-177	341	15	)	)	PUNCT
aji-177	341	16	.	.	PUNCT
aji-177	342	1	bile	bile	NOUN
aji-177	342	2	acid	acid	NOUN
aji-177	342	3	–	–	PUNCT
aji-177	342	4	microbiota	microbiota	NOUN
aji-177	342	5	crosstalk	crosstalk	NOUN
aji-177	342	6	in	in	ADP
aji-177	342	7	gastrointestinal	gastrointestinal	ADJ
aji-177	342	8	inflammation	inflammation	NOUN
aji-177	342	9	and	and	CCONJ
aji-177	342	10	carcinogenesis	carcinogenesis	NOUN
aji-177	342	11	.	.	PUNCT
aji-177	343	1	nature	nature	NOUN
aji-177	343	2	reviews	review	VERB
aji-177	343	3	gastroenterology	gastroenterology	NOUN
aji-177	343	4	&	&	CCONJ
aji-177	343	5	hepatology	hepatology	NOUN
aji-177	343	6	,	,	PUNCT
aji-177	343	7	15(2	15(2	NUM
aji-177	343	8	)	)	PUNCT
aji-177	343	9	,	,	PUNCT
aji-177	344	1	111–128	111–128	NUM
aji-177	344	2	.	.	PUNCT
aji-177	344	3	kaltenmeier	kaltenmeier	PROPN
aji-177	344	4	,	,	PUNCT
aji-177	344	5	c.	c.	PROPN
aji-177	344	6	,	,	PUNCT
aji-177	344	7	yazdani	yazdani	PROPN
aji-177	344	8	,	,	PUNCT
aji-177	344	9	h.	h.	PROPN
aji-177	344	10	o.	o.	PROPN
aji-177	344	11	,	,	PUNCT
aji-177	344	12	morder	morder	PROPN
aji-177	344	13	,	,	PUNCT
aji-177	344	14	k.	k.	PROPN
aji-177	344	15	,	,	PUNCT
aji-177	344	16	geller	geller	PROPN
aji-177	344	17	,	,	PUNCT
aji-177	344	18	d.	d.	PROPN
aji-177	344	19	a.	a.	PROPN
aji-177	344	20	,	,	PUNCT
aji-177	344	21	simmons	simmons	PROPN
aji-177	344	22	,	,	PUNCT
aji-177	344	23	r.	r.	PROPN
aji-177	344	24	l.	l.	PROPN
aji-177	344	25	,	,	PUNCT
aji-177	344	26	&	&	CCONJ
aji-177	344	27	tohme	tohme	PROPN
aji-177	344	28	,	,	PUNCT
aji-177	344	29	s.	s.	PROPN
aji-177	344	30	(	(	PUNCT
aji-177	344	31	2021	2021	NUM
aji-177	344	32	)	)	PUNCT
aji-177	344	33	.	.	PUNCT
aji-177	345	1	neutrophil	neutrophil	ADJ
aji-177	345	2	extracellular	extracellular	ADJ
aji-177	345	3	traps	trap	NOUN
aji-177	345	4	promote	promote	VERB
aji-177	345	5	t	t	NOUN
aji-177	345	6	-	-	PUNCT
aji-177	345	7	cell	cell	NOUN
aji-177	345	8	exhaustion	exhaustion	NOUN
aji-177	345	9	in	in	ADP
aji-177	345	10	the	the	DET
aji-177	345	11	tumor	tumor	NOUN
aji-177	345	12	microenvironment	microenvironment	NOUN
aji-177	345	13	.	.	PUNCT
aji-177	346	1	frontiers	frontier	NOUN
aji-177	346	2	in	in	ADP
aji-177	346	3	immunology	immunology	NOUN
aji-177	346	4	,	,	PUNCT
aji-177	346	5	12	12	NUM
aji-177	346	6	,	,	PUNCT
aji-177	346	7	785222	785222	NUM
aji-177	346	8	.	.	PUNCT
aji-177	347	1	korbecki	korbecki	PROPN
aji-177	347	2	,	,	PUNCT
aji-177	347	3	j.	j.	PROPN
aji-177	347	4	,	,	PUNCT
aji-177	347	5	bosiacki	bosiacki	PROPN
aji-177	347	6	,	,	PUNCT
aji-177	347	7	m.	m.	NOUN
aji-177	347	8	,	,	PUNCT
aji-177	347	9	pilarczyk	pilarczyk	NOUN
aji-177	347	10	,	,	PUNCT
aji-177	347	11	m.	m.	NOUN
aji-177	347	12	,	,	PUNCT
aji-177	347	13	kot	kot	PROPN
aji-177	347	14	,	,	PUNCT
aji-177	347	15	m.	m.	NOUN
aji-177	347	16	,	,	PUNCT
aji-177	347	17	defort	defort	NOUN
aji-177	347	18	,	,	PUNCT
aji-177	347	19	p.	p.	NOUN
aji-177	347	20	,	,	PUNCT
aji-177	347	21	walaszek	walaszek	NOUN
aji-177	347	22	,	,	PUNCT
aji-177	347	23	i.	i.	PROPN
aji-177	347	24	,	,	PUNCT
aji-177	347	25	…	…	PUNCT
aji-177	347	26	baranowskabosiacka	baranowskabosiacka	NOUN
aji-177	347	27	,	,	PUNCT
aji-177	347	28	i.	i.	PROPN
aji-177	347	29	(	(	PUNCT
aji-177	347	30	2025	2025	NUM
aji-177	347	31	)	)	PUNCT
aji-177	347	32	.	.	PUNCT
aji-177	348	1	the	the	DET
aji-177	348	2	cxcl1	cxcl1	PROPN
aji-177	348	3	–	–	PUNCT
aji-177	348	4	cxcr2	cxcr2	NOUN
aji-177	348	5	axis	axis	NOUN
aji-177	348	6	as	as	ADP
aji-177	348	7	a	a	DET
aji-177	348	8	component	component	NOUN
aji-177	348	9	of	of	ADP
aji-177	348	10	therapy	therapy	NOUN
aji-177	348	11	resistance	resistance	NOUN
aji-177	348	12	,	,	PUNCT
aji-177	348	13	a	a	DET
aji-177	348	14	source	source	NOUN
aji-177	348	15	of	of	ADP
aji-177	348	16	side	side	NOUN
aji-177	348	17	effects	effect	NOUN
aji-177	348	18	in	in	ADP
aji-177	348	19	cancer	cancer	NOUN
aji-177	348	20	treatment	treatment	NOUN
aji-177	348	21	,	,	PUNCT
aji-177	348	22	and	and	CCONJ
aji-177	348	23	a	a	DET
aji-177	348	24	therapeutic	therapeutic	ADJ
aji-177	348	25	target	target	NOUN
aji-177	348	26	.	.	PUNCT
aji-177	349	1	cancers	cancer	NOUN
aji-177	349	2	,	,	PUNCT
aji-177	349	3	17(10	17(10	NUM
aji-177	349	4	)	)	PUNCT
aji-177	349	5	,	,	PUNCT
aji-177	349	6	1674	1674	NUM
aji-177	349	7	.	.	PUNCT
aji-177	350	1	kullberg	kullberg	PROPN
aji-177	350	2	,	,	PUNCT
aji-177	350	3	r.	r.	PROPN
aji-177	350	4	f.	f.	PROPN
aji-177	350	5	,	,	PUNCT
aji-177	350	6	van	van	PROPN
aji-177	350	7	linge	linge	PROPN
aji-177	350	8	,	,	PUNCT
aji-177	350	9	c.	c.	PROPN
aji-177	350	10	c.	c.	PROPN
aji-177	350	11	,	,	PUNCT
aji-177	350	12	haak	haak	PROPN
aji-177	350	13	,	,	PUNCT
aji-177	350	14	b.	b.	PROPN
aji-177	350	15	w.	w.	PROPN
aji-177	350	16	,	,	PUNCT
aji-177	350	17	paul	paul	PROPN
aji-177	350	18	,	,	PUNCT
aji-177	350	19	p.	p.	PROPN
aji-177	350	20	s.	s.	PROPN
aji-177	350	21	,	,	PUNCT
aji-177	350	22	butler	butler	PROPN
aji-177	350	23	,	,	PUNCT
aji-177	350	24	j.	j.	PROPN
aji-177	350	25	m.	m.	PROPN
aji-177	350	26	,	,	PUNCT
aji-177	350	27	wolff	wolff	NOUN
aji-177	350	28	,	,	PUNCT
aji-177	350	29	n.	n.	NOUN
aji-177	350	30	,	,	PUNCT
aji-177	350	31	…	…	PUNCT
aji-177	350	32	wiersinga	wiersinga	ADV
aji-177	350	33	,	,	PUNCT
aji-177	350	34	w.	w.	PROPN
aji-177	350	35	j.	j.	PROPN
aji-177	350	36	(	(	PUNCT
aji-177	350	37	2025	2025	NUM
aji-177	350	38	)	)	PUNCT
aji-177	350	39	.	.	PUNCT
aji-177	351	1	effect	effect	NOUN
aji-177	351	2	of	of	ADP
aji-177	351	3	the	the	DET
aji-177	351	4	gut	gut	NOUN
aji-177	351	5	microbiota	microbiota	NOUN
aji-177	351	6	-	-	PUNCT
aji-177	351	7	derived	derive	VERB
aji-177	351	8	tryptophan	tryptophan	NOUN
aji-177	351	9	metabolite	metabolite	NOUN
aji-177	351	10	indole-3	indole-3	NOUN
aji-177	351	11	-	-	PUNCT
aji-177	351	12	acetic	acetic	ADJ
aji-177	351	13	acid	acid	NOUN
aji-177	351	14	in	in	ADP
aji-177	351	15	pneumonia	pneumonia	NOUN
aji-177	351	16	.	.	PUNCT
aji-177	352	1	nature	nature	NOUN
aji-177	352	2	communications	communication	NOUN
aji-177	352	3	,	,	PUNCT
aji-177	352	4	16(1	16(1	NUM
aji-177	352	5	)	)	PUNCT
aji-177	352	6	,	,	PUNCT
aji-177	352	7	8565	8565	NUM
aji-177	352	8	.	.	PUNCT
aji-177	353	1	liu	liu	PROPN
aji-177	353	2	,	,	PUNCT
aji-177	353	3	q.	q.	PROPN
aji-177	353	4	,	,	PUNCT
aji-177	353	5	chen	chen	PROPN
aji-177	353	6	,	,	PUNCT
aji-177	353	7	r.	r.	PROPN
aji-177	353	8	,	,	PUNCT
aji-177	353	9	zhang	zhang	PROPN
aji-177	353	10	,	,	PUNCT
aji-177	353	11	z.	z.	PROPN
aji-177	353	12	,	,	PUNCT
aji-177	353	13	sha	sha	PROPN
aji-177	353	14	,	,	PUNCT
aji-177	353	15	z.	z.	PROPN
aji-177	353	16	,	,	PUNCT
aji-177	353	17	&	&	CCONJ
aji-177	353	18	wu	wu	PROPN
aji-177	353	19	,	,	PUNCT
aji-177	353	20	h.	h.	PROPN
aji-177	353	21	(	(	PUNCT
aji-177	353	22	2025	2025	NUM
aji-177	353	23	)	)	PUNCT
aji-177	353	24	.	.	PUNCT
aji-177	354	1	mechanisms	mechanism	NOUN
aji-177	354	2	and	and	CCONJ
aji-177	354	3	immune	immune	ADJ
aji-177	354	4	crosstalk	crosstalk	NOUN
aji-177	354	5	of	of	ADP
aji-177	354	6	neutrophil	neutrophil	ADJ
aji-177	354	7	extracellular	extracellular	ADJ
aji-177	354	8	traps	trap	NOUN
aji-177	354	9	in	in	ADP
aji-177	354	10	response	response	NOUN
aji-177	354	11	to	to	ADP
aji-177	354	12	infection	infection	NOUN
aji-177	354	13	.	.	PUNCT
aji-177	355	1	mbio	mbio	PROPN
aji-177	355	2	,	,	PUNCT
aji-177	355	3	16(5	16(5	NUM
aji-177	355	4	)	)	PUNCT
aji-177	355	5	,	,	PUNCT
aji-177	355	6	e00189	e00189	PROPN
aji-177	355	7	-	-	PUNCT
aji-177	355	8	25	25	NUM
aji-177	355	9	.	.	PUNCT
aji-177	356	1	lu	lu	PROPN
aji-177	356	2	,	,	PUNCT
aji-177	356	3	s.	s.	PROPN
aji-177	356	4	,	,	PUNCT
aji-177	356	5	zhao	zhao	PROPN
aji-177	356	6	,	,	PUNCT
aji-177	356	7	q.	q.	PROPN
aji-177	356	8	,	,	PUNCT
aji-177	356	9	guan	guan	PROPN
aji-177	356	10	,	,	PUNCT
aji-177	356	11	y.	y.	PROPN
aji-177	356	12	,	,	PUNCT
aji-177	356	13	sun	sun	PROPN
aji-177	356	14	,	,	PUNCT
aji-177	356	15	z.	z.	PROPN
aji-177	356	16	,	,	PUNCT
aji-177	356	17	li	li	PROPN
aji-177	356	18	,	,	PUNCT
aji-177	356	19	w.	w.	PROPN
aji-177	356	20	,	,	PUNCT
aji-177	356	21	guo	guo	PROPN
aji-177	356	22	,	,	PUNCT
aji-177	356	23	s.	s.	PROPN
aji-177	356	24	,	,	PUNCT
aji-177	356	25	&	&	CCONJ
aji-177	356	26	zhang	zhang	PROPN
aji-177	356	27	,	,	PUNCT
aji-177	356	28	a.	a.	PROPN
aji-177	356	29	(	(	PUNCT
aji-177	356	30	2024	2024	NUM
aji-177	356	31	)	)	PUNCT
aji-177	356	32	.	.	PUNCT
aji-177	357	1	the	the	DET
aji-177	357	2	communication	communication	NOUN
aji-177	357	3	mechanism	mechanism	NOUN
aji-177	357	4	of	of	ADP
aji-177	357	5	the	the	DET
aji-177	357	6	gut	gut	NOUN
aji-177	357	7	–	–	PUNCT
aji-177	357	8	brain	brain	NOUN
aji-177	357	9	axis	axis	NOUN
aji-177	357	10	and	and	CCONJ
aji-177	357	11	its	its	PRON
aji-177	357	12	effect	effect	NOUN
aji-177	357	13	on	on	ADP
aji-177	357	14	central	central	ADJ
aji-177	357	15	nervous	nervous	ADJ
aji-177	357	16	system	system	NOUN
aji-177	357	17	diseases	disease	NOUN
aji-177	357	18	:	:	PUNCT
aji-177	357	19	a	a	DET
aji-177	357	20	systematic	systematic	ADJ
aji-177	357	21	review	review	NOUN
aji-177	357	22	.	.	PUNCT
aji-177	358	1	biomedicine	biomedicine	NOUN
aji-177	358	2	&	&	CCONJ
aji-177	358	3	pharmacotherapy	pharmacotherapy	NOUN
aji-177	358	4	,	,	PUNCT
aji-177	358	5	178	178	NUM
aji-177	358	6	,	,	PUNCT
aji-177	358	7	117207	117207	NUM
aji-177	358	8	.	.	PUNCT
aji-177	359	1	ma	ma	PROPN
aji-177	359	2	,	,	PUNCT
aji-177	359	3	z.	z.	PROPN
aji-177	359	4	,	,	PUNCT
aji-177	359	5	wang	wang	PROPN
aji-177	359	6	,	,	PUNCT
aji-177	359	7	z.	z.	PROPN
aji-177	359	8	,	,	PUNCT
aji-177	359	9	cao	cao	PROPN
aji-177	359	10	,	,	PUNCT
aji-177	359	11	j.	j.	PROPN
aji-177	359	12	,	,	PUNCT
aji-177	359	13	dong	dong	PROPN
aji-177	359	14	,	,	PUNCT
aji-177	359	15	y.	y.	PROPN
aji-177	359	16	,	,	PUNCT
aji-177	359	17	&	&	CCONJ
aji-177	359	18	chen	chen	PROPN
aji-177	359	19	,	,	PUNCT
aji-177	359	20	y.	y.	PROPN
aji-177	359	21	(	(	PUNCT
aji-177	359	22	2025	2025	NUM
aji-177	359	23	)	)	PUNCT
aji-177	359	24	.	.	PUNCT
aji-177	360	1	regulatory	regulatory	ADJ
aji-177	360	2	roles	role	NOUN
aji-177	360	3	of	of	ADP
aji-177	360	4	intestinal	intestinal	ADJ
aji-177	360	5	cd4	cd4	PROPN
aji-177	360	6	+	+	PROPN
aji-177	360	7	t	t	NOUN
aji-177	360	8	cells	cell	NOUN
aji-177	360	9	in	in	ADP
aji-177	360	10	inflammation	inflammation	NOUN
aji-177	360	11	and	and	CCONJ
aji-177	360	12	their	their	PRON
aji-177	360	13	modulation	modulation	NOUN
aji-177	360	14	by	by	ADP
aji-177	360	15	the	the	DET
aji-177	360	16	intestinal	intestinal	ADJ
aji-177	360	17	microbiota	microbiota	NOUN
aji-177	360	18	.	.	PUNCT
aji-177	361	1	gut	gut	NOUN
aji-177	361	2	microbes	microbe	NOUN
aji-177	361	3	,	,	PUNCT
aji-177	361	4	17(1	17(1	NUM
aji-177	361	5	)	)	PUNCT
aji-177	361	6	,	,	PUNCT
aji-177	361	7	2560019	2560019	NUM
aji-177	361	8	.	.	PUNCT
aji-177	362	1	mager	mager	PROPN
aji-177	362	2	,	,	PUNCT
aji-177	362	3	l.	l.	PROPN
aji-177	362	4	f.	f.	PROPN
aji-177	362	5	,	,	PUNCT
aji-177	362	6	burkhard	burkhard	PROPN
aji-177	362	7	,	,	PUNCT
aji-177	362	8	r.	r.	PROPN
aji-177	362	9	,	,	PUNCT
aji-177	362	10	pett	pett	PROPN
aji-177	362	11	,	,	PUNCT
aji-177	362	12	n.	n.	PROPN
aji-177	362	13	,	,	PUNCT
aji-177	362	14	cooke	cooke	PROPN
aji-177	362	15	,	,	PUNCT
aji-177	362	16	n.	n.	PROPN
aji-177	362	17	c.	c.	PROPN
aji-177	362	18	,	,	PUNCT
aji-177	362	19	brown	brown	PROPN
aji-177	362	20	,	,	PUNCT
aji-177	362	21	k.	k.	PROPN
aji-177	362	22	,	,	PUNCT
aji-177	362	23	ramay	ramay	PROPN
aji-177	362	24	,	,	PUNCT
aji-177	362	25	h.	h.	PROPN
aji-177	362	26	,	,	PUNCT
aji-177	362	27	…	…	PUNCT
aji-177	362	28	mccoy	mccoy	PROPN
aji-177	362	29	,	,	PUNCT
aji-177	362	30	k.	k.	PROPN
aji-177	362	31	d.	d.	PROPN
aji-177	362	32	(	(	PUNCT
aji-177	362	33	2020	2020	NUM
aji-177	362	34	)	)	PUNCT
aji-177	362	35	.	.	PUNCT
aji-177	363	1	microbiome	microbiome	NOUN
aji-177	363	2	-	-	PUNCT
aji-177	363	3	derived	derive	VERB
aji-177	363	4	inosine	inosine	NOUN
aji-177	363	5	modulates	modulate	NOUN
aji-177	363	6	response	response	NOUN
aji-177	363	7	to	to	PART
aji-177	363	8	checkpoint	checkpoint	VERB
aji-177	363	9	inhibitor	inhibitor	NOUN
aji-177	363	10	immunotherapy	immunotherapy	NOUN
aji-177	363	11	.	.	PUNCT
aji-177	364	1	science	science	NOUN
aji-177	364	2	,	,	PUNCT
aji-177	364	3	369(6510	369(6510	NUM
aji-177	364	4	)	)	PUNCT
aji-177	364	5	,	,	PUNCT
aji-177	364	6	1481–1489	1481–1489	NUM
aji-177	364	7	.	.	PUNCT
aji-177	365	1	mager	mager	PROPN
aji-177	365	2	,	,	PUNCT
aji-177	365	3	l.	l.	PROPN
aji-177	365	4	f.	f.	PROPN
aji-177	365	5	,	,	PUNCT
aji-177	365	6	burkhard	burkhard	PROPN
aji-177	365	7	,	,	PUNCT
aji-177	365	8	r.	r.	PROPN
aji-177	365	9	,	,	PUNCT
aji-177	365	10	pett	pett	PROPN
aji-177	365	11	,	,	PUNCT
aji-177	365	12	n.	n.	PROPN
aji-177	365	13	,	,	PUNCT
aji-177	365	14	cooke	cooke	PROPN
aji-177	365	15	,	,	PUNCT
aji-177	365	16	n.	n.	PROPN
aji-177	365	17	c.	c.	PROPN
aji-177	365	18	,	,	PUNCT
aji-177	365	19	brown	brown	PROPN
aji-177	365	20	,	,	PUNCT
aji-177	365	21	k.	k.	PROPN
aji-177	365	22	,	,	PUNCT
aji-177	365	23	ramay	ramay	PROPN
aji-177	365	24	,	,	PUNCT
aji-177	365	25	h.	h.	PROPN
aji-177	365	26	,	,	PUNCT
aji-177	365	27	…	…	PUNCT
aji-177	365	28	mccoy	mccoy	PROPN
aji-177	365	29	,	,	PUNCT
aji-177	365	30	k.	k.	PROPN
aji-177	365	31	d.	d.	PROPN
aji-177	365	32	(	(	PUNCT
aji-177	365	33	2020	2020	NUM
aji-177	365	34	)	)	PUNCT
aji-177	365	35	.	.	PUNCT
aji-177	366	1	microbiome	microbiome	NOUN
aji-177	366	2	-	-	PUNCT
aji-177	366	3	derived	derive	VERB
aji-177	366	4	inosine	inosine	NOUN
aji-177	366	5	modulates	modulate	NOUN
aji-177	366	6	response	response	NOUN
aji-177	366	7	to	to	PART
aji-177	366	8	checkpoint	checkpoint	VERB
aji-177	366	9	inhibitor	inhibitor	NOUN
aji-177	366	10	immunotherapy	immunotherapy	NOUN
aji-177	366	11	.	.	PUNCT
aji-177	367	1	science	science	NOUN
aji-177	367	2	,	,	PUNCT
aji-177	367	3	369(6510	369(6510	NUM
aji-177	367	4	)	)	PUNCT
aji-177	367	5	,	,	PUNCT
aji-177	367	6	1481–1489	1481–1489	NUM
aji-177	367	7	.	.	PUNCT
aji-177	368	1	mariniello	mariniello	PROPN
aji-177	368	2	,	,	PUNCT
aji-177	368	3	a.	a.	PROPN
aji-177	368	4	,	,	PUNCT
aji-177	368	5	borgeaud	borgeaud	NOUN
aji-177	368	6	,	,	PUNCT
aji-177	368	7	m.	m.	NOUN
aji-177	368	8	,	,	PUNCT
aji-177	368	9	weiner	weiner	NOUN
aji-177	368	10	,	,	PUNCT
aji-177	368	11	m.	m.	NOUN
aji-177	368	12	,	,	PUNCT
aji-177	368	13	frisone	frisone	PROPN
aji-177	368	14	,	,	PUNCT
aji-177	368	15	d.	d.	PROPN
aji-177	368	16	,	,	PUNCT
aji-177	368	17	kim	kim	PROPN
aji-177	368	18	,	,	PUNCT
aji-177	368	19	f.	f.	PROPN
aji-177	368	20	,	,	PUNCT
aji-177	368	21	&	&	CCONJ
aji-177	368	22	addeo	addeo	PROPN
aji-177	368	23	,	,	PUNCT
aji-177	368	24	a.	a.	NOUN
aji-177	368	25	(	(	PUNCT
aji-177	368	26	2025	2025	NUM
aji-177	368	27	)	)	PUNCT
aji-177	368	28	.	.	PUNCT
aji-177	369	1	primary	primary	ADJ
aji-177	369	2	and	and	CCONJ
aji-177	369	3	acquired	acquire	VERB
aji-177	369	4	resistance	resistance	NOUN
aji-177	369	5	to	to	ADP
aji-177	369	6	immunotherapy	immunotherapy	NOUN
aji-177	369	7	with	with	ADP
aji-177	369	8	checkpoint	checkpoint	NOUN
aji-177	369	9	inhibitors	inhibitor	NOUN
aji-177	369	10	in	in	ADP
aji-177	369	11	nsclc	nsclc	NOUN
aji-177	369	12	:	:	PUNCT
aji-177	369	13	from	from	ADP
aji-177	369	14	bedside	bedside	NOUN
aji-177	369	15	to	to	PART
aji-177	369	16	bench	bench	VERB
aji-177	369	17	and	and	CCONJ
aji-177	369	18	back	back	ADV
aji-177	369	19	.	.	PUNCT
aji-177	370	1	biodrugs	biodrug	NOUN
aji-177	370	2	,	,	PUNCT
aji-177	370	3	39(2	39(2	NUM
aji-177	370	4	)	)	PUNCT
aji-177	370	5	,	,	PUNCT
aji-177	370	6	215	215	NUM
aji-177	370	7	.	.	PUNCT
aji-177	370	8	parada	parada	PROPN
aji-177	370	9	venegas	venegas	PROPN
aji-177	370	10	,	,	PUNCT
aji-177	370	11	d.	d.	PROPN
aji-177	370	12	,	,	PUNCT
aji-177	370	13	de	de	PROPN
aji-177	370	14	la	la	X
aji-177	370	15	fuente	fuente	NOUN
aji-177	370	16	,	,	PUNCT
aji-177	370	17	m.	m.	PROPN
aji-177	370	18	k.	k.	PROPN
aji-177	370	19	,	,	PUNCT
aji-177	370	20	landskron	landskron	PROPN
aji-177	370	21	,	,	PUNCT
aji-177	370	22	g.	g.	PROPN
aji-177	370	23	,	,	PUNCT
aji-177	370	24	gonzález	gonzález	PROPN
aji-177	370	25	,	,	PUNCT
aji-177	370	26	m.	m.	PROPN
aji-177	370	27	j.	j.	PROPN
aji-177	370	28	,	,	PUNCT
aji-177	370	29	quera	quera	PROPN
aji-177	370	30	,	,	PUNCT
aji-177	370	31	r.	r.	PROPN
aji-177	370	32	,	,	PUNCT
aji-177	370	33	dijkstra	dijkstra	PROPN
aji-177	370	34	,	,	PUNCT
aji-177	370	35	g.	g.	PROPN
aji-177	370	36	,	,	PUNCT
aji-177	370	37	…	…	PUNCT
aji-177	370	38	hermoso	hermoso	NOUN
aji-177	370	39	,	,	PUNCT
aji-177	370	40	m.	m.	NOUN
aji-177	370	41	a.	a.	NOUN
aji-177	370	42	(	(	PUNCT
aji-177	370	43	2019	2019	NUM
aji-177	370	44	)	)	PUNCT
aji-177	370	45	.	.	PUNCT
aji-177	371	1	short	short	ADJ
aji-177	371	2	-	-	PUNCT
aji-177	371	3	chain	chain	NOUN
aji-177	371	4	fatty	fatty	NOUN
aji-177	371	5	acids	acid	NOUN
aji-177	371	6	(	(	PUNCT
aji-177	371	7	scfas)-mediated	scfas)-mediate	VERB
aji-177	371	8	gut	gut	NOUN
aji-177	371	9	epithelial	epithelial	ADJ
aji-177	371	10	and	and	CCONJ
aji-177	371	11	immune	immune	ADJ
aji-177	371	12	regulation	regulation	NOUN
aji-177	371	13	and	and	CCONJ
aji-177	371	14	its	its	PRON
aji-177	371	15	relevance	relevance	NOUN
aji-177	371	16	for	for	ADP
aji-177	371	17	inflammatory	inflammatory	ADJ
aji-177	371	18	bowel	bowel	NOUN
aji-177	371	19	diseases	disease	NOUN
aji-177	371	20	.	.	PUNCT
aji-177	372	1	frontiers	frontier	NOUN
aji-177	372	2	in	in	ADP
aji-177	372	3	immunology	immunology	NOUN
aji-177	372	4	,	,	PUNCT
aji-177	372	5	10	10	NUM
aji-177	372	6	,	,	PUNCT
aji-177	372	7	277	277	NUM
aji-177	372	8	.	.	PUNCT
aji-177	373	1	perrone	perrone	PROPN
aji-177	373	2	,	,	PUNCT
aji-177	373	3	p.	p.	NOUN
aji-177	373	4	,	,	PUNCT
aji-177	373	5	&	&	CCONJ
aji-177	373	6	d’angelo	d’angelo	PROPN
aji-177	373	7	,	,	PUNCT
aji-177	373	8	s.	s.	PROPN
aji-177	373	9	(	(	PUNCT
aji-177	373	10	2025	2025	NUM
aji-177	373	11	)	)	PUNCT
aji-177	373	12	.	.	PUNCT
aji-177	374	1	gut	gut	VERB
aji-177	374	2	microbiota	microbiota	NOUN
aji-177	374	3	modulation	modulation	NOUN
aji-177	374	4	through	through	ADP
aji-177	374	5	mediterranean	mediterranean	PROPN
aji-177	374	6	diet	diet	NOUN
aji-177	374	7	foods	food	NOUN
aji-177	374	8	:	:	PUNCT
aji-177	374	9	implications	implication	NOUN
aji-177	374	10	for	for	ADP
aji-177	374	11	human	human	ADJ
aji-177	374	12	health	health	NOUN
aji-177	374	13	.	.	PUNCT
aji-177	375	1	nutrients	nutrient	NOUN
aji-177	375	2	,	,	PUNCT
aji-177	375	3	17(6	17(6	NUM
aji-177	375	4	)	)	PUNCT
aji-177	375	5	,	,	PUNCT
aji-177	375	6	948	948	NUM
aji-177	375	7	.	.	X
aji-177	375	8	pirini	pirini	PROPN
aji-177	375	9	,	,	PUNCT
aji-177	375	10	f.	f.	PROPN
aji-177	375	11	,	,	PUNCT
aji-177	375	12	ferrari	ferrari	PROPN
aji-177	375	13	,	,	PUNCT
aji-177	375	14	a.	a.	NOUN
aji-177	375	15	,	,	PUNCT
aji-177	375	16	jandoubi	jandoubi	NOUN
aji-177	375	17	,	,	PUNCT
aji-177	375	18	m.	m.	NOUN
aji-177	375	19	,	,	PUNCT
aji-177	375	20	azzali	azzali	ADJ
aji-177	375	21	,	,	PUNCT
aji-177	375	22	i.	i.	PROPN
aji-177	375	23	,	,	PUNCT
aji-177	375	24	angeli	angeli	PROPN
aji-177	375	25	,	,	PUNCT
aji-177	375	26	d.	d.	PROPN
aji-177	375	27	,	,	PUNCT
aji-177	375	28	mondrone	mondrone	PROPN
aji-177	375	29	,	,	PUNCT
aji-177	375	30	r.	r.	PROPN
aji-177	375	31	,	,	PUNCT
aji-177	375	32	…	…	PUNCT
aji-177	375	33	simonetti	simonetti	NOUN
aji-177	375	34	,	,	PUNCT
aji-177	375	35	g.	g.	PROPN
aji-177	375	36	(	(	PUNCT
aji-177	375	37	2025	2025	NUM
aji-177	375	38	)	)	PUNCT
aji-177	375	39	.	.	PUNCT
aji-177	376	1	polyamines	polyamine	NOUN
aji-177	376	2	at	at	ADP
aji-177	376	3	the	the	DET
aji-177	376	4	crossroad	crossroad	NOUN
aji-177	376	5	between	between	ADP
aji-177	376	6	cell	cell	NOUN
aji-177	376	7	metabolism	metabolism	NOUN
aji-177	376	8	and	and	CCONJ
aji-177	376	9	epigenetic	epigenetic	ADJ
aji-177	376	10	regulation	regulation	NOUN
aji-177	376	11	in	in	ADP
aji-177	376	12	acute	acute	ADJ
aji-177	376	13	leukemias	leukemia	NOUN
aji-177	376	14	.	.	PUNCT
aji-177	377	1	cell	cell	NOUN
aji-177	377	2	death	death	NOUN
aji-177	377	3	discovery	discovery	NOUN
aji-177	377	4	,	,	PUNCT
aji-177	377	5	11(1	11(1	NUM
aji-177	377	6	)	)	PUNCT
aji-177	377	7	,	,	PUNCT
aji-177	377	8	301	301	NUM
aji-177	377	9	.	.	PUNCT
aji-177	378	1	puleston	puleston	PROPN
aji-177	378	2	,	,	PUNCT
aji-177	378	3	d.	d.	PROPN
aji-177	378	4	j.	j.	PROPN
aji-177	378	5	,	,	PUNCT
aji-177	378	6	buck	buck	PROPN
aji-177	378	7	,	,	PUNCT
aji-177	378	8	m.	m.	NOUN
aji-177	378	9	d.	d.	PROPN
aji-177	378	10	,	,	PUNCT
aji-177	378	11	geltink	geltink	VERB
aji-177	378	12	,	,	PUNCT
aji-177	378	13	r.	r.	PROPN
aji-177	378	14	i.	i.	PROPN
aji-177	378	15	k.	k.	PROPN
aji-177	378	16	,	,	PUNCT
aji-177	378	17	kyle	kyle	PROPN
aji-177	378	18	,	,	PUNCT
aji-177	378	19	r.	r.	PROPN
aji-177	378	20	l.	l.	PROPN
aji-177	378	21	,	,	PUNCT
aji-177	378	22	caputa	caputa	PROPN
aji-177	378	23	,	,	PUNCT
aji-177	378	24	g.	g.	PROPN
aji-177	378	25	,	,	PUNCT
aji-177	378	26	o'sullivan	o'sullivan	PROPN
aji-177	378	27	,	,	PUNCT
aji-177	378	28	d.	d.	PROPN
aji-177	378	29	,	,	PUNCT
aji-177	378	30	…	…	PUNCT
aji-177	378	31	pearce	pearce	PROPN
aji-177	378	32	,	,	PUNCT
aji-177	378	33	e.	e.	PROPN
aji-177	378	34	l.	l.	PROPN
aji-177	378	35	(	(	PUNCT
aji-177	378	36	2019	2019	NUM
aji-177	378	37	)	)	PUNCT
aji-177	378	38	.	.	PUNCT
aji-177	379	1	polyamines	polyamine	NOUN
aji-177	379	2	and	and	CCONJ
aji-177	379	3	eif5a	eif5a	PROPN
aji-177	379	4	hypusination	hypusination	NOUN
aji-177	379	5	modulate	modulate	VERB
aji-177	379	6	jimoh	jimoh	PROPN
aji-177	379	7	et	et	PROPN
aji-177	379	8	al	al	PROPN
aji-177	379	9	.	.	PROPN
aji-177	379	10	;	;	PUNCT
aji-177	380	1	asian	asian	PROPN
aji-177	380	2	j.	j.	PROPN
aji-177	380	3	immunol	immunol	PROPN
aji-177	380	4	.	.	PROPN
aji-177	380	5	,	,	PUNCT
aji-177	380	6	vol	vol	NOUN
aji-177	380	7	.	.	PROPN
aji-177	380	8	8	8	NUM
aji-177	380	9	,	,	PUNCT
aji-177	380	10	no	no	INTJ
aji-177	380	11	.	.	NOUN
aji-177	380	12	1	1	NUM
aji-177	380	13	,	,	PUNCT
aji-177	380	14	pp	pp	ADJ
aji-177	380	15	.	.	PUNCT
aji-177	381	1	257	257	NUM
aji-177	381	2	-	-	SYM
aji-177	381	3	268	268	NUM
aji-177	381	4	,	,	PUNCT
aji-177	381	5	2025	2025	NUM
aji-177	381	6	;	;	PUNCT
aji-177	381	7	article	article	NOUN
aji-177	381	8	no.aji.147982	no.aji.147982	VERB
aji-177	381	9	268	268	NUM
aji-177	381	10	mitochondrial	mitochondrial	ADJ
aji-177	381	11	respiration	respiration	NOUN
aji-177	381	12	and	and	CCONJ
aji-177	381	13	macrophage	macrophage	ADJ
aji-177	381	14	activation	activation	NOUN
aji-177	381	15	.	.	PUNCT
aji-177	382	1	cell	cell	NOUN
aji-177	382	2	metabolism	metabolism	NOUN
aji-177	382	3	,	,	PUNCT
aji-177	382	4	30(2	30(2	NUM
aji-177	382	5	)	)	PUNCT
aji-177	382	6	,	,	PUNCT
aji-177	382	7	352	352	NUM
aji-177	382	8	–	–	PUNCT
aji-177	382	9	363	363	NUM
aji-177	382	10	.	.	PUNCT
aji-177	383	1	qi	qi	PROPN
aji-177	383	2	,	,	PUNCT
aji-177	383	3	z.	z.	PROPN
aji-177	383	4	,	,	PUNCT
aji-177	383	5	zhang	zhang	PROPN
aji-177	383	6	,	,	PUNCT
aji-177	383	7	w.	w.	PROPN
aji-177	383	8	,	,	PUNCT
aji-177	383	9	zhang	zhang	PROPN
aji-177	383	10	,	,	PUNCT
aji-177	383	11	p.	p.	PROPN
aji-177	383	12	,	,	PUNCT
aji-177	383	13	qu	qu	PROPN
aji-177	383	14	,	,	PUNCT
aji-177	383	15	y.	y.	PROPN
aji-177	383	16	,	,	PUNCT
aji-177	383	17	zhong	zhong	PROPN
aji-177	383	18	,	,	PUNCT
aji-177	383	19	h.	h.	PROPN
aji-177	383	20	,	,	PUNCT
aji-177	383	21	zhou	zhou	PROPN
aji-177	383	22	,	,	PUNCT
aji-177	383	23	l.	l.	PROPN
aji-177	383	24	,	,	PUNCT
aji-177	383	25	…	…	PUNCT
aji-177	383	26	ge	ge	PROPN
aji-177	383	27	,	,	PUNCT
aji-177	383	28	j.	j.	PROPN
aji-177	383	29	(	(	PUNCT
aji-177	383	30	2025	2025	NUM
aji-177	383	31	)	)	PUNCT
aji-177	383	32	.	.	PUNCT
aji-177	384	1	the	the	DET
aji-177	384	2	gut	gut	NOUN
aji-177	384	3	microbiota	microbiota	NOUN
aji-177	384	4	–	–	PUNCT
aji-177	384	5	bile	bile	NOUN
aji-177	384	6	acid	acid	NOUN
aji-177	384	7	–	–	PUNCT
aji-177	384	8	tgr5	tgr5	NOUN
aji-177	384	9	axis	axis	NOUN
aji-177	384	10	orchestrates	orchestrate	VERB
aji-177	384	11	platelet	platelet	NOUN
aji-177	384	12	activation	activation	NOUN
aji-177	384	13	and	and	CCONJ
aji-177	384	14	atherothrombosis	atherothrombosis	NOUN
aji-177	384	15	.	.	PUNCT
aji-177	385	1	nature	nature	NOUN
aji-177	385	2	cardiovascular	cardiovascular	ADJ
aji-177	385	3	research	research	NOUN
aji-177	385	4	,	,	PUNCT
aji-177	385	5	1–18	1–18	NUM
aji-177	385	6	.	.	PUNCT
aji-177	386	1	ribas	ribas	PROPN
aji-177	386	2	,	,	PUNCT
aji-177	386	3	a.	a.	PROPN
aji-177	386	4	,	,	PUNCT
aji-177	386	5	&	&	CCONJ
aji-177	386	6	wolchok	wolchok	PROPN
aji-177	386	7	,	,	PUNCT
aji-177	386	8	j.	j.	PROPN
aji-177	386	9	d.	d.	PROPN
aji-177	386	10	(	(	PUNCT
aji-177	386	11	2018	2018	NUM
aji-177	386	12	)	)	PUNCT
aji-177	386	13	.	.	PUNCT
aji-177	387	1	cancer	cancer	NOUN
aji-177	387	2	immunotherapy	immunotherapy	NOUN
aji-177	387	3	using	use	VERB
aji-177	387	4	checkpoint	checkpoint	NOUN
aji-177	387	5	blockade	blockade	NOUN
aji-177	387	6	.	.	PUNCT
aji-177	388	1	science	science	NOUN
aji-177	388	2	,	,	PUNCT
aji-177	388	3	359(6382	359(6382	NUM
aji-177	388	4	)	)	PUNCT
aji-177	388	5	,	,	PUNCT
aji-177	388	6	1350–1355	1350–1355	NUM
aji-177	388	7	.	.	PUNCT
aji-177	389	1	routy	routy	PROPN
aji-177	389	2	,	,	PUNCT
aji-177	389	3	b.	b.	PROPN
aji-177	389	4	,	,	PUNCT
aji-177	389	5	le	le	X
aji-177	389	6	chatelier	chatelier	ADV
aji-177	389	7	,	,	PUNCT
aji-177	389	8	e.	e.	PROPN
aji-177	389	9	,	,	PUNCT
aji-177	389	10	derosa	derosa	PROPN
aji-177	389	11	,	,	PUNCT
aji-177	389	12	l.	l.	PROPN
aji-177	389	13	,	,	PUNCT
aji-177	389	14	duong	duong	PROPN
aji-177	389	15	,	,	PUNCT
aji-177	389	16	c.	c.	PROPN
aji-177	389	17	p.	p.	PROPN
aji-177	389	18	,	,	PUNCT
aji-177	389	19	alou	alou	PROPN
aji-177	389	20	,	,	PUNCT
aji-177	389	21	m.	m.	NOUN
aji-177	389	22	t.	t.	PROPN
aji-177	389	23	,	,	PUNCT
aji-177	389	24	daillère	daillère	PROPN
aji-177	389	25	,	,	PUNCT
aji-177	389	26	r.	r.	PROPN
aji-177	389	27	,	,	PUNCT
aji-177	389	28	…	…	PUNCT
aji-177	389	29	zitvogel	zitvogel	NOUN
aji-177	389	30	,	,	PUNCT
aji-177	389	31	l.	l.	PROPN
aji-177	389	32	(	(	PUNCT
aji-177	389	33	2018	2018	NUM
aji-177	389	34	)	)	PUNCT
aji-177	389	35	.	.	PUNCT
aji-177	390	1	gut	gut	VERB
aji-177	390	2	microbiome	microbiome	NOUN
aji-177	390	3	influences	influence	NOUN
aji-177	390	4	efficacy	efficacy	NOUN
aji-177	390	5	of	of	ADP
aji-177	390	6	pd-1	pd-1	ADV
aji-177	390	7	–	–	PUNCT
aji-177	390	8	based	base	VERB
aji-177	390	9	immunotherapy	immunotherapy	NOUN
aji-177	390	10	against	against	ADP
aji-177	390	11	epithelial	epithelial	ADJ
aji-177	390	12	tumors	tumor	NOUN
aji-177	390	13	.	.	PUNCT
aji-177	391	1	science	science	NOUN
aji-177	391	2	,	,	PUNCT
aji-177	391	3	359(6371	359(6371	NUM
aji-177	391	4	)	)	PUNCT
aji-177	391	5	,	,	PUNCT
aji-177	391	6	91	91	NUM
aji-177	391	7	–	–	SYM
aji-177	391	8	97	97	NUM
aji-177	391	9	.	.	PUNCT
aji-177	391	10	saha	saha	PROPN
aji-177	391	11	,	,	PUNCT
aji-177	391	12	j.	j.	PROPN
aji-177	391	13	,	,	PUNCT
aji-177	391	14	&	&	CCONJ
aji-177	391	15	goswami	goswami	PROPN
aji-177	391	16	,	,	PUNCT
aji-177	391	17	r.	r.	PROPN
aji-177	391	18	(	(	PUNCT
aji-177	391	19	2025	2025	NUM
aji-177	391	20	)	)	PUNCT
aji-177	391	21	.	.	PUNCT
aji-177	392	1	modulation	modulation	NOUN
aji-177	392	2	of	of	ADP
aji-177	392	3	innate	innate	ADJ
aji-177	392	4	immunity	immunity	NOUN
aji-177	392	5	by	by	ADP
aji-177	392	6	short	short	ADJ
aji-177	392	7	-	-	PUNCT
aji-177	392	8	chain	chain	NOUN
aji-177	392	9	fatty	fatty	NOUN
aji-177	392	10	acids	acid	NOUN
aji-177	392	11	in	in	ADP
aji-177	392	12	probiotic	probiotic	ADJ
aji-177	392	13	and	and	CCONJ
aji-177	392	14	fecal	fecal	ADJ
aji-177	392	15	microbiota	microbiota	NOUN
aji-177	392	16	transplantation	transplantation	NOUN
aji-177	392	17	therapies	therapy	NOUN
aji-177	392	18	for	for	ADP
aji-177	392	19	the	the	DET
aji-177	392	20	treatment	treatment	NOUN
aji-177	392	21	of	of	ADP
aji-177	392	22	colon	colon	NOUN
aji-177	392	23	disorders	disorder	NOUN
aji-177	392	24	.	.	PUNCT
aji-177	393	1	probiotics	probiotic	NOUN
aji-177	393	2	and	and	CCONJ
aji-177	393	3	antimicrobial	antimicrobial	ADJ
aji-177	393	4	proteins	protein	NOUN
aji-177	393	5	,	,	PUNCT
aji-177	393	6	1–27	1–27	PROPN
aji-177	393	7	.	.	PUNCT
aji-177	393	8	teijeira	teijeira	PROPN
aji-177	393	9	,	,	PUNCT
aji-177	393	10	á	á	PROPN
aji-177	393	11	.	.	PROPN
aji-177	393	12	,	,	PUNCT
aji-177	393	13	garasa	garasa	PROPN
aji-177	393	14	,	,	PUNCT
aji-177	393	15	s.	s.	PROPN
aji-177	393	16	,	,	PUNCT
aji-177	393	17	gato	gato	PROPN
aji-177	393	18	,	,	PUNCT
aji-177	393	19	m.	m.	NOUN
aji-177	393	20	,	,	PUNCT
aji-177	393	21	alfaro	alfaro	PROPN
aji-177	393	22	,	,	PUNCT
aji-177	393	23	c.	c.	PROPN
aji-177	393	24	,	,	PUNCT
aji-177	393	25	migueliz	migueliz	NOUN
aji-177	393	26	,	,	PUNCT
aji-177	393	27	i.	i.	NOUN
aji-177	393	28	,	,	PUNCT
aji-177	393	29	cirella	cirella	PROPN
aji-177	393	30	,	,	PUNCT
aji-177	393	31	a.	a.	NOUN
aji-177	393	32	,	,	PUNCT
aji-177	393	33	…	…	PUNCT
aji-177	393	34	melero	melero	NOUN
aji-177	393	35	,	,	PUNCT
aji-177	393	36	i.	i.	NOUN
aji-177	393	37	(	(	PUNCT
aji-177	393	38	2020	2020	NUM
aji-177	393	39	)	)	PUNCT
aji-177	393	40	.	.	PUNCT
aji-177	394	1	cxcr1	cxcr1	NOUN
aji-177	394	2	and	and	CCONJ
aji-177	394	3	cxcr2	cxcr2	VERB
aji-177	394	4	chemokine	chemokine	ADJ
aji-177	394	5	receptor	receptor	NOUN
aji-177	394	6	agonists	agonist	NOUN
aji-177	394	7	produced	produce	VERB
aji-177	394	8	by	by	ADP
aji-177	394	9	tumors	tumor	NOUN
aji-177	394	10	induce	induce	VERB
aji-177	394	11	neutrophil	neutrophil	ADJ
aji-177	394	12	extracellular	extracellular	ADJ
aji-177	394	13	traps	trap	NOUN
aji-177	394	14	that	that	PRON
aji-177	394	15	interfere	interfere	VERB
aji-177	394	16	with	with	ADP
aji-177	394	17	immune	immune	ADJ
aji-177	394	18	cytotoxicity	cytotoxicity	NOUN
aji-177	394	19	.	.	PUNCT
aji-177	395	1	immunity	immunity	NOUN
aji-177	395	2	,	,	PUNCT
aji-177	395	3	52(5	52(5	NUM
aji-177	395	4	)	)	PUNCT
aji-177	395	5	,	,	PUNCT
aji-177	395	6	856–871	856–871	NUM
aji-177	395	7	.	.	PUNCT
aji-177	396	1	tofalo	tofalo	PROPN
aji-177	396	2	,	,	PUNCT
aji-177	396	3	r.	r.	PROPN
aji-177	396	4	,	,	PUNCT
aji-177	396	5	cocchi	cocchi	PROPN
aji-177	396	6	,	,	PUNCT
aji-177	396	7	s.	s.	PROPN
aji-177	396	8	,	,	PUNCT
aji-177	396	9	&	&	CCONJ
aji-177	396	10	suzzi	suzzi	PROPN
aji-177	396	11	,	,	PUNCT
aji-177	396	12	g.	g.	PROPN
aji-177	396	13	(	(	PUNCT
aji-177	396	14	2019	2019	NUM
aji-177	396	15	)	)	PUNCT
aji-177	396	16	.	.	PUNCT
aji-177	397	1	polyamines	polyamine	NOUN
aji-177	397	2	and	and	CCONJ
aji-177	397	3	gut	gut	NOUN
aji-177	397	4	microbiota	microbiota	NOUN
aji-177	397	5	.	.	PUNCT
aji-177	398	1	frontiers	frontier	NOUN
aji-177	398	2	in	in	ADP
aji-177	398	3	nutrition	nutrition	NOUN
aji-177	398	4	,	,	PUNCT
aji-177	398	5	6	6	NUM
aji-177	398	6	,	,	PUNCT
aji-177	398	7	16	16	NUM
aji-177	398	8	.	.	PUNCT
aji-177	399	1	xi	xi	PROPN
aji-177	399	2	,	,	PUNCT
aji-177	399	3	x.	x.	NOUN
aji-177	399	4	,	,	PUNCT
aji-177	399	5	ye	ye	PROPN
aji-177	399	6	,	,	PUNCT
aji-177	399	7	q.	q.	PROPN
aji-177	399	8	,	,	PUNCT
aji-177	399	9	fan	fan	PROPN
aji-177	399	10	,	,	PUNCT
aji-177	399	11	d.	d.	PROPN
aji-177	399	12	,	,	PUNCT
aji-177	399	13	cao	cao	PROPN
aji-177	399	14	,	,	PUNCT
aji-177	399	15	x.	x.	PROPN
aji-177	399	16	,	,	PUNCT
aji-177	399	17	wang	wang	PROPN
aji-177	399	18	,	,	PUNCT
aji-177	399	19	q.	q.	PROPN
aji-177	399	20	,	,	PUNCT
aji-177	399	21	wang	wang	PROPN
aji-177	399	22	,	,	PUNCT
aji-177	399	23	x.	x.	PROPN
aji-177	399	24	,	,	PUNCT
aji-177	399	25	…	…	PUNCT
aji-177	399	26	xiao	xiao	PROPN
aji-177	399	27	,	,	PUNCT
aji-177	399	28	c.	c.	PROPN
aji-177	399	29	(	(	PUNCT
aji-177	399	30	2022	2022	NUM
aji-177	399	31	)	)	PUNCT
aji-177	399	32	.	.	PUNCT
aji-177	400	1	polycyclic	polycyclic	NOUN
aji-177	400	2	aromatic	aromatic	ADJ
aji-177	400	3	hydrocarbons	hydrocarbon	NOUN
aji-177	400	4	affect	affect	VERB
aji-177	400	5	rheumatoid	rheumatoid	VERB
aji-177	400	6	arthritis	arthritis	NOUN
aji-177	400	7	pathogenesis	pathogenesis	NOUN
aji-177	400	8	via	via	ADP
aji-177	400	9	aryl	aryl	NOUN
aji-177	400	10	hydrocarbon	hydrocarbon	NOUN
aji-177	400	11	receptor	receptor	NOUN
aji-177	400	12	.	.	PUNCT
aji-177	401	1	frontiers	frontier	NOUN
aji-177	401	2	in	in	ADP
aji-177	401	3	immunology	immunology	NOUN
aji-177	401	4	,	,	PUNCT
aji-177	401	5	13	13	NUM
aji-177	401	6	,	,	PUNCT
aji-177	401	7	797815	797815	NUM
aji-177	401	8	.	.	PUNCT
aji-177	402	1	yang	yang	PROPN
aji-177	402	2	,	,	PUNCT
aji-177	402	3	l.	l.	PROPN
aji-177	402	4	,	,	PUNCT
aji-177	402	5	liu	liu	PROPN
aji-177	402	6	,	,	PUNCT
aji-177	402	7	q.	q.	PROPN
aji-177	402	8	,	,	PUNCT
aji-177	402	9	zhang	zhang	PROPN
aji-177	402	10	,	,	PUNCT
aji-177	402	11	x.	x.	PROPN
aji-177	402	12	,	,	PUNCT
aji-177	402	13	liu	liu	PROPN
aji-177	402	14	,	,	PUNCT
aji-177	402	15	x.	x.	PROPN
aji-177	402	16	,	,	PUNCT
aji-177	402	17	zhou	zhou	PROPN
aji-177	402	18	,	,	PUNCT
aji-177	402	19	b.	b.	PROPN
aji-177	402	20	,	,	PUNCT
aji-177	402	21	chen	chen	PROPN
aji-177	402	22	,	,	PUNCT
aji-177	402	23	j.	j.	PROPN
aji-177	402	24	,	,	PUNCT
aji-177	402	25	…	…	PUNCT
aji-177	402	26	song	song	NOUN
aji-177	402	27	,	,	PUNCT
aji-177	402	28	e.	e.	PROPN
aji-177	402	29	(	(	PUNCT
aji-177	402	30	2020	2020	NUM
aji-177	402	31	)	)	PUNCT
aji-177	402	32	.	.	PUNCT
aji-177	403	1	dna	dna	PROPN
aji-177	403	2	of	of	ADP
aji-177	403	3	neutrophil	neutrophil	ADJ
aji-177	403	4	extracellular	extracellular	ADJ
aji-177	403	5	traps	trap	NOUN
aji-177	403	6	promotes	promote	VERB
aji-177	403	7	cancer	cancer	NOUN
aji-177	403	8	metastasis	metastasis	NOUN
aji-177	403	9	via	via	ADP
aji-177	403	10	ccdc25	ccdc25	NOUN
aji-177	403	11	.	.	PUNCT
aji-177	404	1	nature	nature	NOUN
aji-177	404	2	,	,	PUNCT
aji-177	404	3	583(7814	583(7814	NUM
aji-177	404	4	)	)	PUNCT
aji-177	404	5	,	,	PUNCT
aji-177	404	6	133–138	133–138	NUM
aji-177	404	7	.	.	PUNCT
aji-177	405	1	zhang	zhang	PROPN
aji-177	405	2	,	,	PUNCT
aji-177	405	3	j.	j.	PROPN
aji-177	405	4	,	,	PUNCT
aji-177	405	5	miao	miao	PROPN
aji-177	405	6	,	,	PUNCT
aji-177	405	7	c.	c.	PROPN
aji-177	405	8	,	,	PUNCT
aji-177	405	9	&	&	CCONJ
aji-177	405	10	zhang	zhang	PROPN
aji-177	405	11	,	,	PUNCT
aji-177	405	12	h.	h.	PROPN
aji-177	405	13	(	(	PUNCT
aji-177	405	14	2025	2025	NUM
aji-177	405	15	)	)	PUNCT
aji-177	405	16	.	.	PUNCT
aji-177	406	1	targeting	target	VERB
aji-177	406	2	neutrophil	neutrophil	ADJ
aji-177	406	3	extracellular	extracellular	ADJ
aji-177	406	4	traps	trap	NOUN
aji-177	406	5	in	in	ADP
aji-177	406	6	cancer	cancer	NOUN
aji-177	406	7	progression	progression	NOUN
aji-177	406	8	and	and	CCONJ
aji-177	406	9	metastasis	metastasis	NOUN
aji-177	406	10	.	.	PUNCT
aji-177	407	1	theranostics	theranostic	NOUN
aji-177	407	2	,	,	PUNCT
aji-177	407	3	15(12	15(12	NUM
aji-177	407	4	)	)	PUNCT
aji-177	407	5	,	,	PUNCT
aji-177	407	6	5846	5846	NUM
aji-177	407	7	.	.	PUNCT
aji-177	408	1	zhang	zhang	PROPN
aji-177	408	2	,	,	PUNCT
aji-177	408	3	m.	m.	NOUN
aji-177	408	4	,	,	PUNCT
aji-177	408	5	zhong	zhong	PROPN
aji-177	408	6	,	,	PUNCT
aji-177	408	7	j.	j.	PROPN
aji-177	408	8	,	,	PUNCT
aji-177	408	9	shen	shen	PROPN
aji-177	408	10	,	,	PUNCT
aji-177	408	11	y.	y.	PROPN
aji-177	408	12	,	,	PUNCT
aji-177	408	13	&	&	CCONJ
aji-177	408	14	song	song	PROPN
aji-177	408	15	,	,	PUNCT
aji-177	408	16	z.	z.	PROPN
aji-177	408	17	(	(	PUNCT
aji-177	408	18	2025	2025	NUM
aji-177	408	19	)	)	PUNCT
aji-177	408	20	.	.	PUNCT
aji-177	408	21	crosstalk	crosstalk	VERB
aji-177	408	22	between	between	ADP
aji-177	408	23	bile	bile	NOUN
aji-177	408	24	acids	acid	NOUN
aji-177	408	25	and	and	CCONJ
aji-177	408	26	gut	gut	NOUN
aji-177	408	27	microbiota	microbiota	NOUN
aji-177	408	28	:	:	PUNCT
aji-177	408	29	a	a	DET
aji-177	408	30	potential	potential	ADJ
aji-177	408	31	target	target	NOUN
aji-177	408	32	for	for	ADP
aji-177	408	33	precancerous	precancerous	ADJ
aji-177	408	34	lesions	lesion	NOUN
aji-177	408	35	of	of	ADP
aji-177	408	36	gastric	gastric	ADJ
aji-177	408	37	cancer	cancer	NOUN
aji-177	408	38	.	.	PUNCT
aji-177	409	1	frontiers	frontier	NOUN
aji-177	409	2	in	in	ADP
aji-177	409	3	pharmacology	pharmacology	NOUN
aji-177	409	4	,	,	PUNCT
aji-177	409	5	16	16	NUM
aji-177	409	6	,	,	PUNCT
aji-177	409	7	1533141	1533141	NUM
aji-177	409	8	.	.	PUNCT
aji-177	410	1	zhang	zhang	PROPN
aji-177	410	2	,	,	PUNCT
aji-177	410	3	t.	t.	PROPN
aji-177	410	4	,	,	PUNCT
aji-177	410	5	yu	yu	PROPN
aji-177	410	6	,	,	PUNCT
aji-177	410	7	z.	z.	PROPN
aji-177	410	8	,	,	PUNCT
aji-177	410	9	xu	xu	PROPN
aji-177	410	10	,	,	PUNCT
aji-177	410	11	y.	y.	PROPN
aji-177	410	12	,	,	PUNCT
aji-177	410	13	zhao	zhao	PROPN
aji-177	410	14	,	,	PUNCT
aji-177	410	15	l.	l.	PROPN
aji-177	410	16	,	,	PUNCT
aji-177	410	17	zhu	zhu	PROPN
aji-177	410	18	,	,	PUNCT
aji-177	410	19	f.	f.	PROPN
aji-177	410	20	,	,	PUNCT
aji-177	410	21	zhou	zhou	PROPN
aji-177	410	22	,	,	PUNCT
aji-177	410	23	y.	y.	PROPN
aji-177	410	24	,	,	PUNCT
aji-177	410	25	…	…	PUNCT
aji-177	410	26	gong	gong	NOUN
aji-177	410	27	,	,	PUNCT
aji-177	410	28	j.	j.	PROPN
aji-177	410	29	(	(	PUNCT
aji-177	410	30	2025	2025	NUM
aji-177	410	31	)	)	PUNCT
aji-177	410	32	.	.	PUNCT
aji-177	411	1	tryptophan	tryptophan	NOUN
aji-177	411	2	metabolites	metabolite	NOUN
aji-177	411	3	improve	improve	VERB
aji-177	411	4	intestinal	intestinal	ADJ
aji-177	411	5	mucosal	mucosal	NOUN
aji-177	411	6	barrier	barrier	NOUN
aji-177	411	7	via	via	ADP
aji-177	411	8	the	the	DET
aji-177	411	9	aryl	aryl	NOUN
aji-177	411	10	hydrocarbon	hydrocarbon	NOUN
aji-177	411	11	receptor	receptor	NOUN
aji-177	411	12	–	–	PUNCT
aji-177	411	13	interleukin-22	interleukin-22	PROPN
aji-177	411	14	pathway	pathway	NOUN
aji-177	411	15	in	in	ADP
aji-177	411	16	murine	murine	ADJ
aji-177	411	17	dextran	dextran	ADJ
aji-177	411	18	sulfate	sulfate	NOUN
aji-177	411	19	sodium	sodium	NOUN
aji-177	411	20	–	–	PUNCT
aji-177	411	21	induced	induce	VERB
aji-177	411	22	pouchitis	pouchitis	NOUN
aji-177	411	23	.	.	PUNCT
aji-177	412	1	diseases	disease	NOUN
aji-177	412	2	of	of	ADP
aji-177	412	3	the	the	DET
aji-177	412	4	colon	colon	NOUN
aji-177	412	5	&	&	CCONJ
aji-177	412	6	rectum	rectum	NOUN
aji-177	412	7	,	,	PUNCT
aji-177	412	8	68(1	68(1	NOUN
aji-177	412	9	)	)	PUNCT
aji-177	412	10	,	,	PUNCT
aji-177	412	11	77–90	77–90	NUM
aji-177	412	12	.	.	PUNCT
aji-177	413	1	zhao	zhao	PROPN
aji-177	413	2	,	,	PUNCT
aji-177	413	3	g.	g.	PROPN
aji-177	413	4	,	,	PUNCT
aji-177	413	5	li	li	PROPN
aji-177	413	6	,	,	PUNCT
aji-177	413	7	x.	x.	PROPN
aji-177	413	8	,	,	PUNCT
aji-177	413	9	zhang	zhang	PROPN
aji-177	413	10	,	,	PUNCT
aji-177	413	11	y.	y.	PROPN
aji-177	413	12	,	,	PUNCT
aji-177	413	13	wang	wang	PROPN
aji-177	413	14	,	,	PUNCT
aji-177	413	15	x.	x.	PROPN
aji-177	413	16	,	,	PUNCT
aji-177	413	17	deng	deng	PROPN
aji-177	413	18	,	,	PUNCT
aji-177	413	19	l.	l.	PROPN
aji-177	413	20	,	,	PUNCT
aji-177	413	21	xu	xu	PROPN
aji-177	413	22	,	,	PUNCT
aji-177	413	23	j.	j.	PROPN
aji-177	413	24	,	,	PUNCT
aji-177	413	25	…	…	PUNCT
aji-177	413	26	fu	fu	ADJ
aji-177	413	27	,	,	PUNCT
aji-177	413	28	p.	p.	NOUN
aji-177	413	29	(	(	PUNCT
aji-177	413	30	2025	2025	NUM
aji-177	413	31	)	)	PUNCT
aji-177	413	32	.	.	PUNCT
aji-177	414	1	intricating	intricating	NOUN
aji-177	414	2	connections	connection	NOUN
aji-177	414	3	:	:	PUNCT
aji-177	414	4	the	the	DET
aji-177	414	5	role	role	NOUN
aji-177	414	6	of	of	ADP
aji-177	414	7	ferroptosis	ferroptosis	NOUN
aji-177	414	8	in	in	ADP
aji-177	414	9	systemic	systemic	ADJ
aji-177	414	10	lupus	lupus	PROPN
aji-177	414	11	erythematosus	erythematosus	PROPN
aji-177	414	12	.	.	PUNCT
aji-177	415	1	frontiers	frontier	NOUN
aji-177	415	2	in	in	ADP
aji-177	415	3	immunology	immunology	NOUN
aji-177	415	4	,	,	PUNCT
aji-177	415	5	16	16	NUM
aji-177	415	6	,	,	PUNCT
aji-177	415	7	1534926	1534926	NUM
aji-177	415	8	.	.	PUNCT
aji-177	416	1	zhao	zhao	PROPN
aji-177	416	2	,	,	PUNCT
aji-177	416	3	s.	s.	PROPN
aji-177	416	4	,	,	PUNCT
aji-177	416	5	gong	gong	PROPN
aji-177	416	6	,	,	PUNCT
aji-177	416	7	z.	z.	PROPN
aji-177	416	8	,	,	PUNCT
aji-177	416	9	zhou	zhou	PROPN
aji-177	416	10	,	,	PUNCT
aji-177	416	11	j.	j.	PROPN
aji-177	416	12	,	,	PUNCT
aji-177	416	13	tian	tian	PROPN
aji-177	416	14	,	,	PUNCT
aji-177	416	15	c.	c.	PROPN
aji-177	416	16	,	,	PUNCT
aji-177	416	17	gao	gao	PROPN
aji-177	416	18	,	,	PUNCT
aji-177	416	19	y.	y.	PROPN
aji-177	416	20	,	,	PUNCT
aji-177	416	21	xu	xu	PROPN
aji-177	416	22	,	,	PUNCT
aji-177	416	23	c.	c.	PROPN
aji-177	416	24	,	,	PUNCT
aji-177	416	25	…	…	PUNCT
aji-177	416	26	wu	wu	PROPN
aji-177	416	27	,	,	PUNCT
aji-177	416	28	j.	j.	PROPN
aji-177	416	29	(	(	PUNCT
aji-177	416	30	2016	2016	NUM
aji-177	416	31	)	)	PUNCT
aji-177	416	32	.	.	PUNCT
aji-177	417	1	deoxycholic	deoxycholic	ADJ
aji-177	417	2	acid	acid	PROPN
aji-177	417	3	triggers	trigger	VERB
aji-177	417	4	nlrp3	nlrp3	NOUN
aji-177	417	5	inflammasome	inflammasome	NOUN
aji-177	417	6	activation	activation	NOUN
aji-177	417	7	and	and	CCONJ
aji-177	417	8	aggravates	aggravate	VERB
aji-177	417	9	dss	dss	NOUN
aji-177	417	10	-	-	PUNCT
aji-177	417	11	induced	induce	VERB
aji-177	417	12	colitis	colitis	NOUN
aji-177	417	13	in	in	ADP
aji-177	417	14	mice	mouse	NOUN
aji-177	417	15	.	.	PUNCT
aji-177	418	1	frontiers	frontier	NOUN
aji-177	418	2	in	in	ADP
aji-177	418	3	immunology	immunology	NOUN
aji-177	418	4	,	,	PUNCT
aji-177	418	5	7	7	NUM
aji-177	418	6	,	,	PUNCT
aji-177	418	7	536	536	NUM
aji-177	418	8	.	.	PUNCT
aji-177	419	1	zhou	zhou	PROPN
aji-177	419	2	,	,	PUNCT
aji-177	419	3	b.	b.	PROPN
aji-177	419	4	,	,	PUNCT
aji-177	419	5	gao	gao	PROPN
aji-177	419	6	,	,	PUNCT
aji-177	419	7	y.	y.	PROPN
aji-177	419	8	,	,	PUNCT
aji-177	419	9	zhang	zhang	PROPN
aji-177	419	10	,	,	PUNCT
aji-177	419	11	p.	p.	PROPN
aji-177	419	12	,	,	PUNCT
aji-177	419	13	&	&	CCONJ
aji-177	419	14	chu	chu	PROPN
aji-177	419	15	,	,	PUNCT
aji-177	419	16	q.	q.	PROPN
aji-177	419	17	(	(	PUNCT
aji-177	419	18	2021	2021	NUM
aji-177	419	19	)	)	PUNCT
aji-177	419	20	.	.	PUNCT
aji-177	419	21	acquired	acquire	VERB
aji-177	419	22	resistance	resistance	NOUN
aji-177	419	23	to	to	ADP
aji-177	419	24	immune	immune	ADJ
aji-177	419	25	checkpoint	checkpoint	NOUN
aji-177	419	26	blockades	blockade	NOUN
aji-177	419	27	:	:	PUNCT
aji-177	419	28	the	the	DET
aji-177	419	29	underlying	underlie	VERB
aji-177	419	30	mechanisms	mechanism	NOUN
aji-177	419	31	and	and	CCONJ
aji-177	419	32	potential	potential	ADJ
aji-177	419	33	strategies	strategy	NOUN
aji-177	419	34	.	.	PUNCT
aji-177	420	1	frontiers	frontier	NOUN
aji-177	420	2	in	in	ADP
aji-177	420	3	immunology	immunology	NOUN
aji-177	420	4	,	,	PUNCT
aji-177	420	5	12	12	NUM
aji-177	420	6	,	,	PUNCT
aji-177	420	7	693609	693609	NUM
aji-177	420	8	.	.	PUNCT
aji-177	421	1	https://doi.org/10.3389/fimmu.2021.693609	https://doi.org/10.3389/fimmu.2021.693609	PROPN
aji-177	421	2	disclaimer	disclaimer	ADJ
aji-177	421	3	/	/	SYM
aji-177	421	4	publisher	publisher	NOUN
aji-177	421	5	’s	’s	PART
aji-177	421	6	note	note	NOUN
aji-177	421	7	:	:	PUNCT
aji-177	421	8	the	the	DET
aji-177	421	9	statements	statement	NOUN
aji-177	421	10	,	,	PUNCT
aji-177	421	11	opinions	opinion	NOUN
aji-177	421	12	and	and	CCONJ
aji-177	421	13	data	datum	NOUN
aji-177	421	14	contained	contain	VERB
aji-177	421	15	in	in	ADP
aji-177	421	16	all	all	DET
aji-177	421	17	publications	publication	NOUN
aji-177	421	18	are	be	AUX
aji-177	421	19	solely	solely	ADV
aji-177	421	20	those	those	PRON
aji-177	421	21	of	of	ADP
aji-177	421	22	the	the	DET
aji-177	421	23	individual	individual	ADJ
aji-177	421	24	author(s	author(s	PROPN
aji-177	421	25	)	)	PUNCT
aji-177	421	26	and	and	CCONJ
aji-177	421	27	contributor(s	contributor(s	NOUN
aji-177	421	28	)	)	PUNCT
aji-177	421	29	and	and	CCONJ
aji-177	421	30	not	not	PART
aji-177	421	31	of	of	ADP
aji-177	421	32	the	the	DET
aji-177	421	33	publisher	publisher	NOUN
aji-177	421	34	and/or	and/or	CCONJ
aji-177	421	35	the	the	DET
aji-177	421	36	editor(s	editor(s	NOUN
aji-177	421	37	)	)	PUNCT
aji-177	421	38	.	.	PUNCT
aji-177	422	1	this	this	DET
aji-177	422	2	publisher	publisher	NOUN
aji-177	422	3	and/or	and/or	CCONJ
aji-177	422	4	the	the	DET
aji-177	422	5	editor(s	editor(s	NOUN
aji-177	422	6	)	)	PUNCT
aji-177	422	7	disclaim	disclaim	VERB
aji-177	422	8	responsibility	responsibility	NOUN
aji-177	422	9	for	for	ADP
aji-177	422	10	any	any	DET
aji-177	422	11	injury	injury	NOUN
aji-177	422	12	to	to	ADP
aji-177	422	13	people	people	NOUN
aji-177	422	14	or	or	CCONJ
aji-177	422	15	property	property	NOUN
aji-177	422	16	resulting	result	VERB
aji-177	422	17	from	from	ADP
aji-177	422	18	any	any	DET
aji-177	422	19	ideas	idea	NOUN
aji-177	422	20	,	,	PUNCT
aji-177	422	21	methods	method	NOUN
aji-177	422	22	,	,	PUNCT
aji-177	422	23	instructions	instruction	NOUN
aji-177	422	24	or	or	CCONJ
aji-177	422	25	products	product	NOUN
aji-177	422	26	referred	refer	VERB
aji-177	422	27	to	to	ADP
aji-177	422	28	in	in	ADP
aji-177	422	29	the	the	DET
aji-177	422	30	content	content	NOUN
aji-177	422	31	.	.	PUNCT
aji-177	423	1	_	_	PUNCT
aji-177	424	1	_	_	PUNCT
aji-177	425	1	_	_	PUNCT
aji-177	426	1	_	_	PUNCT
aji-177	427	1	_	_	PUNCT
aji-177	428	1	_	_	PUNCT
aji-177	429	1	_	_	PUNCT
aji-177	430	1	_	_	PUNCT
aji-177	431	1	_	_	PUNCT
aji-177	432	1	_	_	PUNCT
aji-177	433	1	_	_	PUNCT
aji-177	434	1	_	_	PUNCT
aji-177	435	1	_	_	PUNCT
aji-177	436	1	_	_	PUNCT
aji-177	437	1	_	_	PUNCT
aji-177	438	1	_	_	PUNCT
aji-177	439	1	_	_	PUNCT
aji-177	440	1	_	_	PUNCT
aji-177	441	1	_	_	PUNCT
aji-177	442	1	_	_	PUNCT
aji-177	443	1	_	_	PUNCT
aji-177	444	1	_	_	PUNCT
aji-177	445	1	_	_	PUNCT
aji-177	446	1	_	_	PUNCT
aji-177	447	1	_	_	PUNCT
aji-177	448	1	_	_	PUNCT
aji-177	449	1	_	_	PUNCT
aji-177	450	1	_	_	PUNCT
aji-177	451	1	_	_	PUNCT
aji-177	452	1	_	_	PUNCT
aji-177	453	1	_	_	PUNCT
aji-177	454	1	_	_	PUNCT
aji-177	455	1	_	_	PUNCT
aji-177	456	1	_	_	PUNCT
aji-177	457	1	_	_	PUNCT
aji-177	458	1	_	_	PUNCT
aji-177	459	1	_	_	PUNCT
aji-177	460	1	_	_	PUNCT
aji-177	461	1	_	_	PUNCT
aji-177	462	1	_	_	PUNCT
aji-177	463	1	_	_	PUNCT
aji-177	464	1	_	_	PUNCT
aji-177	465	1	_	_	PUNCT
aji-177	466	1	_	_	PUNCT
aji-177	467	1	_	_	PUNCT
aji-177	468	1	_	_	PUNCT
aji-177	469	1	_	_	PUNCT
aji-177	470	1	_	_	PUNCT
aji-177	471	1	_	_	PUNCT
aji-177	472	1	_	_	PUNCT
aji-177	473	1	_	_	PUNCT
aji-177	474	1	_	_	PUNCT
aji-177	475	1	_	_	PUNCT
aji-177	476	1	_	_	PUNCT
aji-177	477	1	_	_	PUNCT
aji-177	478	1	_	_	PUNCT
aji-177	479	1	_	_	PUNCT
aji-177	480	1	_	_	PUNCT
aji-177	481	1	_	_	PUNCT
aji-177	482	1	_	_	PUNCT
aji-177	483	1	_	_	PUNCT
aji-177	484	1	_	_	PUNCT
aji-177	485	1	_	_	PUNCT
aji-177	486	1	_	_	PUNCT
aji-177	487	1	_	_	PUNCT
aji-177	488	1	_	_	PUNCT
aji-177	489	1	_	_	PUNCT
aji-177	490	1	_	_	PUNCT
aji-177	491	1	_	_	PUNCT
aji-177	492	1	_	_	PUNCT
aji-177	493	1	_	_	PUNCT
aji-177	494	1	_	_	PUNCT
aji-177	495	1	_	_	PUNCT
aji-177	496	1	_	_	PUNCT
aji-177	497	1	_	_	PUNCT
aji-177	498	1	_	_	PUNCT
aji-177	499	1	_	_	PUNCT
aji-177	500	1	_	_	PUNCT
aji-177	501	1	_	_	PUNCT
aji-177	502	1	_	_	PUNCT
aji-177	503	1	_	_	PUNCT
aji-177	504	1	©	©	PRON
aji-177	504	2	copyright	copyright	NOUN
aji-177	504	3	(	(	PUNCT
aji-177	504	4	2025	2025	NUM
aji-177	504	5	):	):	PUNCT
aji-177	504	6	author(s	author(s	NOUN
aji-177	504	7	)	)	PUNCT
aji-177	504	8	.	.	PUNCT
aji-177	505	1	the	the	DET
aji-177	505	2	licensee	licensee	NOUN
aji-177	505	3	is	be	AUX
aji-177	505	4	the	the	DET
aji-177	505	5	journal	journal	PROPN
aji-177	505	6	publisher	publisher	NOUN
aji-177	505	7	.	.	PUNCT
aji-177	506	1	this	this	PRON
aji-177	506	2	is	be	AUX
aji-177	506	3	an	an	DET
aji-177	506	4	open	open	ADJ
aji-177	506	5	access	access	NOUN
aji-177	506	6	article	article	NOUN
aji-177	506	7	distributed	distribute	VERB
aji-177	506	8	under	under	ADP
aji-177	506	9	the	the	DET
aji-177	506	10	terms	term	NOUN
aji-177	506	11	of	of	ADP
aji-177	506	12	the	the	DET
aji-177	506	13	creative	creative	ADJ
aji-177	506	14	commons	common	NOUN
aji-177	506	15	attribution	attribution	NOUN
aji-177	506	16	license	license	NOUN
aji-177	506	17	(	(	PUNCT
aji-177	506	18	http://creativecommons.org/licenses/by/4.0	http://creativecommons.org/licenses/by/4.0	NOUN
aji-177	506	19	)	)	PUNCT
aji-177	506	20	,	,	PUNCT
aji-177	506	21	which	which	PRON
aji-177	506	22	permits	permit	VERB
aji-177	506	23	unrestricted	unrestricted	ADJ
aji-177	506	24	use	use	NOUN
aji-177	506	25	,	,	PUNCT
aji-177	506	26	distribution	distribution	NOUN
aji-177	506	27	,	,	PUNCT
aji-177	506	28	and	and	CCONJ
aji-177	506	29	reproduction	reproduction	NOUN
aji-177	506	30	in	in	ADP
aji-177	506	31	any	any	DET
aji-177	506	32	medium	medium	NOUN
aji-177	506	33	,	,	PUNCT
aji-177	506	34	provided	provide	VERB
aji-177	506	35	the	the	DET
aji-177	506	36	original	original	ADJ
aji-177	506	37	work	work	NOUN
aji-177	506	38	is	be	AUX
aji-177	506	39	properly	properly	ADV
aji-177	506	40	cited	cite	VERB
aji-177	506	41	.	.	PUNCT
aji-177	507	1	peer	peer	NOUN
aji-177	507	2	-	-	PUNCT
aji-177	507	3	review	review	NOUN
aji-177	507	4	history	history	NOUN
aji-177	507	5	:	:	PUNCT
aji-177	507	6	the	the	DET
aji-177	507	7	peer	peer	NOUN
aji-177	507	8	review	review	NOUN
aji-177	507	9	history	history	NOUN
aji-177	507	10	for	for	ADP
aji-177	507	11	this	this	DET
aji-177	507	12	paper	paper	NOUN
aji-177	507	13	can	can	AUX
aji-177	507	14	be	be	AUX
aji-177	507	15	accessed	access	VERB
aji-177	507	16	here	here	ADV
aji-177	507	17	:	:	PUNCT
aji-177	507	18	https://pr.sdiarticle5.com/review-history/147982	https://pr.sdiarticle5.com/review-history/147982	NUM
aji-177	508	1	https://pr.sdiarticle5.com/review-history/147982	https://pr.sdiarticle5.com/review-history/147982	INTJ