id	sid	tid	token	lemma	pos
aji-34	1	1	_	_	PUNCT
aji-34	2	1	_	_	PUNCT
aji-34	3	1	_	_	PUNCT
aji-34	4	1	_	_	PUNCT
aji-34	5	1	_	_	PUNCT
aji-34	6	1	_	_	PUNCT
aji-34	7	1	_	_	PUNCT
aji-34	8	1	_	_	PUNCT
aji-34	9	1	_	_	PUNCT
aji-34	10	1	_	_	PUNCT
aji-34	11	1	_	_	PUNCT
aji-34	12	1	_	_	PUNCT
aji-34	13	1	_	_	PUNCT
aji-34	14	1	_	_	PUNCT
aji-34	15	1	_	_	PUNCT
aji-34	16	1	_	_	PUNCT
aji-34	17	1	_	_	PUNCT
aji-34	18	1	_	_	PUNCT
aji-34	19	1	_	_	PUNCT
aji-34	20	1	_	_	PUNCT
aji-34	21	1	_	_	PUNCT
aji-34	22	1	_	_	PUNCT
aji-34	23	1	_	_	PUNCT
aji-34	24	1	_	_	PUNCT
aji-34	25	1	_	_	PUNCT
aji-34	26	1	_	_	PUNCT
aji-34	27	1	_	_	PUNCT
aji-34	28	1	_	_	PUNCT
aji-34	29	1	_	_	PUNCT
aji-34	30	1	_	_	PUNCT
aji-34	31	1	_	_	PUNCT
aji-34	32	1	_	_	PUNCT
aji-34	33	1	_	_	PUNCT
aji-34	34	1	_	_	PUNCT
aji-34	35	1	_	_	PUNCT
aji-34	36	1	_	_	PUNCT
aji-34	37	1	_	_	PUNCT
aji-34	38	1	_	_	PUNCT
aji-34	39	1	_	_	PUNCT
aji-34	40	1	_	_	PUNCT
aji-34	41	1	_	_	PUNCT
aji-34	42	1	_	_	PUNCT
aji-34	43	1	_	_	PUNCT
aji-34	44	1	_	_	PUNCT
aji-34	45	1	_	_	PUNCT
aji-34	46	1	_	_	PUNCT
aji-34	47	1	_	_	PUNCT
aji-34	48	1	_	_	PUNCT
aji-34	49	1	_	_	PUNCT
aji-34	50	1	_	_	PUNCT
aji-34	51	1	_	_	PUNCT
aji-34	52	1	_	_	PUNCT
aji-34	53	1	_	_	PUNCT
aji-34	54	1	_	_	PUNCT
aji-34	55	1	_	_	PUNCT
aji-34	56	1	_	_	PUNCT
aji-34	57	1	_	_	PUNCT
aji-34	58	1	_	_	PUNCT
aji-34	59	1	_	_	PUNCT
aji-34	60	1	_	_	PUNCT
aji-34	61	1	_	_	PUNCT
aji-34	62	1	_	_	PUNCT
aji-34	63	1	_	_	PUNCT
aji-34	64	1	_	_	PUNCT
aji-34	65	1	_	_	PUNCT
aji-34	66	1	_	_	PUNCT
aji-34	67	1	_	_	PUNCT
aji-34	68	1	_	_	PUNCT
aji-34	69	1	_	_	PUNCT
aji-34	70	1	_	_	PUNCT
aji-34	71	1	_	_	PUNCT
aji-34	72	1	_	_	PUNCT
aji-34	73	1	_	_	PUNCT
aji-34	74	1	_	_	PUNCT
aji-34	75	1	_	_	PUNCT
aji-34	76	1	_	_	PUNCT
aji-34	77	1	_	_	PUNCT
aji-34	78	1	_	_	PUNCT
aji-34	79	1	_	_	PUNCT
aji-34	80	1	_	_	PUNCT
aji-34	81	1	_	_	PUNCT
aji-34	82	1	_	_	PUNCT
aji-34	83	1	_	_	PUNCT
aji-34	84	1	_	_	PUNCT
aji-34	85	1	_	_	PUNCT
aji-34	86	1	_	_	PUNCT
aji-34	87	1	_	_	PUNCT
aji-34	88	1	_	_	PUNCT
aji-34	89	1	_	_	PUNCT
aji-34	90	1	_	_	PUNCT
aji-34	91	1	_	_	PUNCT
aji-34	92	1	_	_	PUNCT
aji-34	93	1	_	_	PUNCT
aji-34	94	1	_	_	PUNCT
aji-34	95	1	_	_	PUNCT
aji-34	96	1	_	_	PUNCT
aji-34	97	1	_	_	PUNCT
aji-34	98	1	_	_	PUNCT
aji-34	99	1	_	_	PUNCT
aji-34	100	1	_	_	PUNCT
aji-34	101	1	_	_	PUNCT
aji-34	102	1	*	*	PUNCT
aji-34	102	2	corresponding	correspond	VERB
aji-34	102	3	author	author	NOUN
aji-34	102	4	:	:	PUNCT
aji-34	102	5	e	e	NOUN
aji-34	102	6	-	-	NOUN
aji-34	102	7	mail	mail	NOUN
aji-34	102	8	:	:	PUNCT
aji-34	102	9	elmafary@gmail.com	elmafary@gmail.com	PROPN
aji-34	102	10	;	;	PUNCT
aji-34	102	11	asian	asian	ADJ
aji-34	102	12	journal	journal	NOUN
aji-34	102	13	of	of	ADP
aji-34	102	14	immunology	immunology	NOUN
aji-34	102	15	3(1	3(1	NUM
aji-34	102	16	):	):	PUNCT
aji-34	102	17	259	259	NUM
aji-34	102	18	-	-	SYM
aji-34	102	19	268	268	NUM
aji-34	102	20	,	,	PUNCT
aji-34	102	21	2020	2020	NUM
aji-34	102	22	;	;	PUNCT
aji-34	102	23	article	article	NOUN
aji-34	102	24	no.aji.57314	no.aji.57314	PROPN
aji-34	102	25	role	role	NOUN
aji-34	102	26	of	of	ADP
aji-34	102	27	inflammatory	inflammatory	ADJ
aji-34	102	28	cytokines	cytokine	NOUN
aji-34	102	29	in	in	ADP
aji-34	102	30	the	the	DET
aji-34	102	31	pathogenesis	pathogenesis	NOUN
aji-34	102	32	of	of	ADP
aji-34	102	33	rheumatoid	rheumatoid	NOUN
aji-34	102	34	arthritis	arthritis	NOUN
aji-34	102	35	and	and	CCONJ
aji-34	102	36	novel	novel	ADJ
aji-34	102	37	therapeutic	therapeutic	ADJ
aji-34	102	38	targets	target	NOUN
aji-34	102	39	shaayau	shaayau	NOUN
aji-34	102	40	shehu1	shehu1	PROPN
aji-34	103	1	*	*	PROPN
aji-34	103	2	,	,	PUNCT
aji-34	103	3	abdulaziz	abdulaziz	PROPN
aji-34	103	4	umar	umar	PROPN
aji-34	103	5	kurya2	kurya2	PROPN
aji-34	103	6	,	,	PUNCT
aji-34	103	7	usama	usama	PROPN
aji-34	103	8	aliyu1	aliyu1	PROPN
aji-34	103	9	and	and	CCONJ
aji-34	103	10	dinesh	dinesh	PROPN
aji-34	103	11	c.	c.	PROPN
aji-34	103	12	sharma2	sharma2	PROPN
aji-34	104	1	1	1	NUM
aji-34	104	2	department	department	PROPN
aji-34	104	3	of	of	ADP
aji-34	104	4	biochemistry	biochemistry	NOUN
aji-34	104	5	,	,	PUNCT
aji-34	104	6	usmanu	usmanu	PROPN
aji-34	104	7	danfodiyo	danfodiyo	PROPN
aji-34	104	8	university	university	PROPN
aji-34	104	9	,	,	PUNCT
aji-34	104	10	sokoto	sokoto	PROPN
aji-34	104	11	,	,	PUNCT
aji-34	104	12	nigeria	nigeria	PROPN
aji-34	104	13	.	.	PUNCT
aji-34	105	1	2	2	NUM
aji-34	105	2	school	school	NOUN
aji-34	105	3	of	of	ADP
aji-34	105	4	life	life	NOUN
aji-34	105	5	and	and	CCONJ
aji-34	105	6	allied	ally	VERB
aji-34	105	7	health	health	NOUN
aji-34	105	8	sciences	sciences	PROPN
aji-34	105	9	,	,	PUNCT
aji-34	105	10	glocal	glocal	ADJ
aji-34	105	11	university	university	NOUN
aji-34	105	12	,	,	PUNCT
aji-34	105	13	saharanpur	saharanpur	NOUN
aji-34	105	14	,	,	PUNCT
aji-34	105	15	uttar	uttar	PROPN
aji-34	105	16	pradesh	pradesh	PROPN
aji-34	105	17	,	,	PUNCT
aji-34	105	18	india	india	PROPN
aji-34	105	19	.	.	PUNCT
aji-34	106	1	authors	author	NOUN
aji-34	106	2	’	’	PART
aji-34	106	3	contributions	contribution	NOUN
aji-34	106	4	this	this	DET
aji-34	106	5	work	work	NOUN
aji-34	106	6	was	be	AUX
aji-34	106	7	carried	carry	VERB
aji-34	106	8	out	out	ADP
aji-34	106	9	in	in	ADP
aji-34	106	10	collaboration	collaboration	NOUN
aji-34	106	11	among	among	ADP
aji-34	106	12	all	all	DET
aji-34	106	13	authors	author	NOUN
aji-34	106	14	.	.	PUNCT
aji-34	107	1	author	author	NOUN
aji-34	107	2	ss	ss	PROPN
aji-34	107	3	designed	design	VERB
aji-34	107	4	and	and	CCONJ
aji-34	107	5	supervised	supervise	VERB
aji-34	107	6	the	the	DET
aji-34	107	7	study	study	NOUN
aji-34	107	8	.	.	PUNCT
aji-34	108	1	author	author	NOUN
aji-34	108	2	auk	auk	PROPN
aji-34	108	3	wrote	write	VERB
aji-34	108	4	the	the	DET
aji-34	108	5	first	first	ADJ
aji-34	108	6	draft	draft	NOUN
aji-34	108	7	of	of	ADP
aji-34	108	8	the	the	DET
aji-34	108	9	manuscript	manuscript	NOUN
aji-34	108	10	,	,	PUNCT
aji-34	108	11	outline	outline	VERB
aji-34	108	12	the	the	DET
aji-34	108	13	protocol	protocol	NOUN
aji-34	108	14	and	and	CCONJ
aji-34	108	15	performed	perform	VERB
aji-34	108	16	the	the	DET
aji-34	108	17	statistical	statistical	ADJ
aji-34	108	18	analysis	analysis	NOUN
aji-34	108	19	while	while	SCONJ
aji-34	108	20	authors	author	NOUN
aji-34	108	21	ua	ua	PROPN
aji-34	108	22	and	and	CCONJ
aji-34	108	23	dcs	dcs	PROPN
aji-34	108	24	managed	manage	VERB
aji-34	108	25	the	the	DET
aji-34	108	26	literature	literature	NOUN
aji-34	108	27	search	search	NOUN
aji-34	108	28	and	and	CCONJ
aji-34	108	29	analyses	analysis	NOUN
aji-34	108	30	of	of	ADP
aji-34	108	31	the	the	DET
aji-34	108	32	study	study	NOUN
aji-34	108	33	.	.	PUNCT
aji-34	109	1	all	all	DET
aji-34	109	2	authors	author	NOUN
aji-34	109	3	read	read	VERB
aji-34	109	4	and	and	CCONJ
aji-34	109	5	approved	approve	VERB
aji-34	109	6	the	the	DET
aji-34	109	7	final	final	ADJ
aji-34	109	8	manuscript	manuscript	NOUN
aji-34	109	9	.	.	PUNCT
aji-34	110	1	article	article	NOUN
aji-34	110	2	information	information	PROPN
aji-34	110	3	editor(s	editor(s	PROPN
aji-34	110	4	):	):	PUNCT
aji-34	110	5	(	(	PUNCT
aji-34	110	6	1	1	X
aji-34	110	7	)	)	PUNCT
aji-34	110	8	dr	dr	PROPN
aji-34	110	9	.	.	PROPN
aji-34	110	10	jaffu	jaffu	PROPN
aji-34	110	11	othniel	othniel	PROPN
aji-34	110	12	chilongola	chilongola	PROPN
aji-34	110	13	,	,	PUNCT
aji-34	110	14	tumaini	tumaini	NOUN
aji-34	110	15	university	university	PROPN
aji-34	110	16	,	,	PUNCT
aji-34	110	17	tanzania	tanzania	PROPN
aji-34	110	18	.	.	PUNCT
aji-34	111	1	reviewers	reviewer	NOUN
aji-34	111	2	:	:	PUNCT
aji-34	111	3	(	(	PUNCT
aji-34	111	4	1	1	X
aji-34	111	5	)	)	PUNCT
aji-34	111	6	s.	s.	PROPN
aji-34	111	7	tripathy	tripathy	PROPN
aji-34	111	8	,	,	PUNCT
aji-34	111	9	sri	sri	PROPN
aji-34	111	10	vasavi	vasavi	PROPN
aji-34	111	11	institute	institute	PROPN
aji-34	111	12	of	of	ADP
aji-34	111	13	pharmaceutical	pharmaceutical	PROPN
aji-34	111	14	sciences	sciences	PROPN
aji-34	111	15	,	,	PUNCT
aji-34	111	16	india	india	PROPN
aji-34	111	17	.	.	PUNCT
aji-34	112	1	(	(	PUNCT
aji-34	112	2	2	2	X
aji-34	112	3	)	)	PUNCT
aji-34	112	4	ingrid	ingrid	PROPN
aji-34	112	5	patricia	patricia	PROPN
aji-34	112	6	,	,	PUNCT
aji-34	112	7	dávalos	dávalos	PROPN
aji-34	112	8	rodríguez	rodríguez	PROPN
aji-34	112	9	,	,	PUNCT
aji-34	112	10	méxico	méxico	PROPN
aji-34	112	11	.	.	PUNCT
aji-34	113	1	complete	complete	ADJ
aji-34	113	2	peer	peer	NOUN
aji-34	113	3	review	review	NOUN
aji-34	113	4	history	history	NOUN
aji-34	113	5	:	:	PUNCT
aji-34	113	6	http://www.sdiarticle4.com/review-history/57314	http://www.sdiarticle4.com/review-history/57314	PROPN
aji-34	113	7	received	receive	VERB
aji-34	113	8	06	06	NUM
aji-34	113	9	april	april	PROPN
aji-34	113	10	2020	2020	NUM
aji-34	113	11	accepted	accept	VERB
aji-34	113	12	12	12	NUM
aji-34	113	13	june	june	PROPN
aji-34	113	14	2020	2020	NUM
aji-34	113	15	published	publish	VERB
aji-34	113	16	29	29	NUM
aji-34	113	17	june	june	PROPN
aji-34	113	18	2020	2020	NUM
aji-34	113	19	abstract	abstract	ADJ
aji-34	113	20	cytokines	cytokine	NOUN
aji-34	113	21	are	be	AUX
aji-34	113	22	low	low	ADJ
aji-34	113	23	molecular	molecular	ADJ
aji-34	113	24	weight	weight	NOUN
aji-34	113	25	secreted	secrete	VERB
aji-34	113	26	proteins	protein	NOUN
aji-34	113	27	that	that	PRON
aji-34	113	28	mediate	mediate	VERB
aji-34	113	29	and	and	CCONJ
aji-34	113	30	regulate	regulate	VERB
aji-34	113	31	immune	immune	ADJ
aji-34	113	32	responses	response	NOUN
aji-34	113	33	,	,	PUNCT
aji-34	113	34	inflammation	inflammation	NOUN
aji-34	113	35	and	and	CCONJ
aji-34	113	36	hematopoiesis	hematopoiesis	NOUN
aji-34	113	37	;	;	PUNCT
aji-34	113	38	they	they	PRON
aji-34	113	39	act	act	VERB
aji-34	113	40	by	by	ADP
aji-34	113	41	autocrine	autocrine	NOUN
aji-34	113	42	,	,	PUNCT
aji-34	113	43	paracrine	paracrine	NOUN
aji-34	113	44	,	,	PUNCT
aji-34	113	45	endocrine	endocrine	ADJ
aji-34	113	46	and	and	CCONJ
aji-34	113	47	antagonistic	antagonistic	ADJ
aji-34	113	48	mode	mode	NOUN
aji-34	113	49	of	of	ADP
aji-34	113	50	actions	action	NOUN
aji-34	113	51	.	.	PUNCT
aji-34	114	1	cytokines	cytokine	NOUN
aji-34	114	2	have	have	VERB
aji-34	114	3	strong	strong	ADJ
aji-34	114	4	correlation	correlation	NOUN
aji-34	114	5	with	with	ADP
aji-34	114	6	autoimmune	autoimmune	ADJ
aji-34	114	7	disease	disease	NOUN
aji-34	114	8	,	,	PUNCT
aji-34	114	9	the	the	DET
aji-34	114	10	most	most	ADV
aji-34	114	11	prominent	prominent	ADJ
aji-34	114	12	among	among	ADP
aji-34	114	13	others	other	NOUN
aji-34	114	14	is	be	AUX
aji-34	114	15	rheumatoid	rheumatoid	VERB
aji-34	114	16	arthritis	arthritis	NOUN
aji-34	114	17	(	(	PUNCT
aji-34	114	18	ra	ra	NOUN
aji-34	114	19	)	)	PUNCT
aji-34	114	20	which	which	PRON
aji-34	114	21	targets	target	VERB
aji-34	114	22	synovial	synovial	ADJ
aji-34	114	23	joints	joint	NOUN
aji-34	114	24	,	,	PUNCT
aji-34	114	25	and	and	CCONJ
aji-34	114	26	often	often	ADV
aji-34	114	27	accompanied	accompany	VERB
aji-34	114	28	by	by	ADP
aji-34	114	29	an	an	DET
aji-34	114	30	array	array	NOUN
aji-34	114	31	of	of	ADP
aji-34	114	32	extra	extra	ADJ
aji-34	114	33	-	-	ADJ
aji-34	114	34	articular	articular	ADJ
aji-34	114	35	manifestations	manifestation	NOUN
aji-34	114	36	which	which	PRON
aji-34	114	37	are	be	AUX
aji-34	114	38	ultimately	ultimately	ADV
aji-34	114	39	major	major	ADJ
aji-34	114	40	predictors	predictor	NOUN
aji-34	114	41	of	of	ADP
aji-34	114	42	increased	increase	VERB
aji-34	114	43	morbidity	morbidity	NOUN
aji-34	114	44	and	and	CCONJ
aji-34	114	45	mortality	mortality	NOUN
aji-34	114	46	,	,	PUNCT
aji-34	114	47	ra	ra	PROPN
aji-34	114	48	affect	affect	VERB
aji-34	114	49	about	about	ADV
aji-34	114	50	1	1	NUM
aji-34	114	51	%	%	NOUN
aji-34	114	52	of	of	ADP
aji-34	114	53	the	the	DET
aji-34	114	54	world	world	NOUN
aji-34	114	55	population	population	NOUN
aji-34	114	56	and	and	CCONJ
aji-34	114	57	about	about	ADV
aji-34	114	58	0.6	0.6	NUM
aji-34	114	59	%	%	NOUN
aji-34	114	60	of	of	ADP
aji-34	114	61	the	the	DET
aji-34	114	62	american	american	ADJ
aji-34	114	63	population	population	NOUN
aji-34	114	64	with	with	ADP
aji-34	114	65	annual	annual	ADJ
aji-34	114	66	incidence	incidence	NOUN
aji-34	114	67	estimated	estimate	VERB
aji-34	114	68	to	to	ADP
aji-34	114	69	about	about	ADV
aji-34	114	70	40	40	NUM
aji-34	114	71	per	per	ADP
aji-34	114	72	100,000	100,000	NUM
aji-34	114	73	individuals	individual	NOUN
aji-34	114	74	and	and	CCONJ
aji-34	114	75	mostly	mostly	ADV
aji-34	114	76	women	woman	NOUN
aji-34	114	77	.	.	PUNCT
aji-34	115	1	persistent	persistent	ADJ
aji-34	115	2	inflammation	inflammation	NOUN
aji-34	115	3	endorsed	endorse	VERB
aji-34	115	4	by	by	ADP
aji-34	115	5	major	major	ADJ
aji-34	115	6	pro	pro	ADJ
aji-34	115	7	-	-	ADJ
aji-34	115	8	inflammatory	inflammatory	ADJ
aji-34	115	9	cytokines	cytokine	NOUN
aji-34	115	10	such	such	ADJ
aji-34	115	11	as	as	ADP
aji-34	115	12	interleukins	interleukin	NOUN
aji-34	115	13	(	(	PUNCT
aji-34	115	14	il-1	il-1	X
aji-34	115	15	,	,	PUNCT
aji-34	115	16	il-6	il-6	NUM
aji-34	115	17	)	)	PUNCT
aji-34	115	18	and	and	CCONJ
aji-34	115	19	tumor	tumor	NOUN
aji-34	115	20	necrosis	necrosis	NOUN
aji-34	115	21	factors	factor	NOUN
aji-34	115	22	(	(	PUNCT
aji-34	115	23	tnf	tnf	PROPN
aji-34	115	24	-	-	PUNCT
aji-34	115	25	α	α	NOUN
aji-34	115	26	)	)	PUNCT
aji-34	115	27	and	and	CCONJ
aji-34	115	28	imbalance	imbalance	NOUN
aji-34	115	29	between	between	ADP
aji-34	115	30	the	the	DET
aji-34	115	31	proinflammatory	proinflammatory	ADJ
aji-34	115	32	and	and	CCONJ
aji-34	115	33	anti	anti	ADJ
aji-34	115	34	-	-	ADJ
aji-34	115	35	inflammatory	inflammatory	ADJ
aji-34	115	36	cytokines	cytokine	NOUN
aji-34	115	37	is	be	AUX
aji-34	115	38	the	the	DET
aji-34	115	39	main	main	ADJ
aji-34	115	40	pathogenesis	pathogenesis	NOUN
aji-34	115	41	of	of	ADP
aji-34	115	42	ra	ra	PROPN
aji-34	115	43	.	.	PUNCT
aji-34	116	1	evidence	evidence	NOUN
aji-34	116	2	suggests	suggest	VERB
aji-34	116	3	that	that	SCONJ
aji-34	116	4	interaction	interaction	NOUN
aji-34	116	5	between	between	ADP
aji-34	116	6	antigen	antigen	ADV
aji-34	116	7	-	-	PUNCT
aji-34	116	8	presenting	present	VERB
aji-34	116	9	cells	cell	NOUN
aji-34	116	10	and	and	CCONJ
aji-34	116	11	cd4	cd4	PROPN
aji-34	116	12	+	+	PROPN
aji-34	116	13	t	t	PROPN
aji-34	116	14	helper	helper	NOUN
aji-34	116	15	cells	cell	NOUN
aji-34	116	16	is	be	AUX
aji-34	116	17	involved	involve	VERB
aji-34	116	18	in	in	ADP
aji-34	116	19	the	the	DET
aji-34	116	20	induction	induction	NOUN
aji-34	116	21	of	of	ADP
aji-34	116	22	inflammation	inflammation	NOUN
aji-34	116	23	in	in	ADP
aji-34	116	24	ra	ra	PROPN
aji-34	116	25	.	.	PUNCT
aji-34	117	1	continuous	continuous	ADJ
aji-34	117	2	recruitment	recruitment	NOUN
aji-34	117	3	and	and	CCONJ
aji-34	117	4	activation	activation	NOUN
aji-34	117	5	of	of	ADP
aji-34	117	6	macrophages	macrophage	NOUN
aji-34	117	7	and	and	CCONJ
aji-34	117	8	review	review	NOUN
aji-34	117	9	article	article	NOUN
aji-34	117	10	shehu	shehu	VERB
aji-34	117	11	et	et	PROPN
aji-34	117	12	al	al	PROPN
aji-34	117	13	.	.	PROPN
aji-34	117	14	;	;	PUNCT
aji-34	118	1	aji	aji	PROPN
aji-34	118	2	,	,	PUNCT
aji-34	118	3	3(1	3(1	NUM
aji-34	118	4	):	):	PUNCT
aji-34	118	5	259	259	NUM
aji-34	118	6	-	-	SYM
aji-34	118	7	268	268	NUM
aji-34	118	8	,	,	PUNCT
aji-34	118	9	2020	2020	NUM
aji-34	118	10	;	;	PUNCT
aji-34	118	11	article	article	NOUN
aji-34	118	12	no.aji.57314	no.aji.57314	PROPN
aji-34	118	13	260	260	NUM
aji-34	118	14	monocytes	monocyte	VERB
aji-34	118	15	occur	occur	VERB
aji-34	118	16	with	with	ADP
aji-34	118	17	the	the	DET
aji-34	118	18	recruitment	recruitment	NOUN
aji-34	118	19	of	of	ADP
aji-34	118	20	pro	pro	ADJ
aji-34	118	21	-	-	ADJ
aji-34	118	22	inflammatory	inflammatory	ADJ
aji-34	118	23	cytokines	cytokine	NOUN
aji-34	118	24	,	,	PUNCT
aji-34	118	25	specifically	specifically	ADV
aji-34	118	26	tnf	tnf	PROPN
aji-34	118	27	-	-	PUNCT
aji-34	118	28	α	α	PROPN
aji-34	118	29	,	,	PUNCT
aji-34	118	30	il-1	il-1	PUNCT
aji-34	118	31	and	and	CCONJ
aji-34	118	32	il-6	il-6	NOUN
aji-34	118	33	into	into	ADP
aji-34	118	34	the	the	DET
aji-34	118	35	synovial	synovial	ADJ
aji-34	118	36	cavity	cavity	NOUN
aji-34	118	37	resulting	result	VERB
aji-34	118	38	to	to	ADP
aji-34	118	39	loss	loss	NOUN
aji-34	118	40	of	of	ADP
aji-34	118	41	cartilage	cartilage	NOUN
aji-34	118	42	and	and	CCONJ
aji-34	118	43	bone	bone	NOUN
aji-34	118	44	erosion	erosion	NOUN
aji-34	118	45	.	.	PUNCT
aji-34	119	1	these	these	DET
aji-34	119	2	activated	activate	VERB
aji-34	119	3	immune	immune	ADJ
aji-34	119	4	cells	cell	NOUN
aji-34	119	5	stimulate	stimulate	VERB
aji-34	119	6	angiogenesis	angiogenesis	NOUN
aji-34	119	7	,	,	PUNCT
aji-34	119	8	which	which	PRON
aji-34	119	9	explains	explain	VERB
aji-34	119	10	increased	increase	VERB
aji-34	119	11	vascularity	vascularity	NOUN
aji-34	119	12	found	find	VERB
aji-34	119	13	in	in	ADP
aji-34	119	14	the	the	DET
aji-34	119	15	synovium	synovium	NOUN
aji-34	119	16	of	of	ADP
aji-34	119	17	patients	patient	NOUN
aji-34	119	18	with	with	ADP
aji-34	119	19	ra	ra	PROPN
aji-34	119	20	.	.	PUNCT
aji-34	120	1	novel	novel	ADJ
aji-34	120	2	therapeutic	therapeutic	ADJ
aji-34	120	3	targets	target	NOUN
aji-34	120	4	are	be	AUX
aji-34	120	5	developed	develop	VERB
aji-34	120	6	to	to	PART
aji-34	120	7	minimize	minimize	VERB
aji-34	120	8	the	the	DET
aji-34	120	9	morbidity	morbidity	NOUN
aji-34	120	10	rate	rate	NOUN
aji-34	120	11	,	,	PUNCT
aji-34	120	12	the	the	DET
aji-34	120	13	use	use	NOUN
aji-34	120	14	of	of	ADP
aji-34	120	15	tnf	tnf	PROPN
aji-34	120	16	-	-	PUNCT
aji-34	120	17	α	α	PROPN
aji-34	120	18	blockade	blockade	NOUN
aji-34	120	19	drugs	drug	NOUN
aji-34	120	20	such	such	ADJ
aji-34	120	21	as	as	ADP
aji-34	120	22	adalimumab	adalimumab	NOUN
aji-34	120	23	,	,	PUNCT
aji-34	120	24	etanercept	etanercept	NOUN
aji-34	120	25	and	and	CCONJ
aji-34	120	26	infliximab	infliximab	NOUN
aji-34	120	27	is	be	AUX
aji-34	120	28	widely	widely	ADV
aji-34	120	29	approved	approve	VERB
aji-34	120	30	globally	globally	ADV
aji-34	120	31	with	with	ADP
aji-34	120	32	more	more	ADV
aji-34	120	33	precise	precise	ADJ
aji-34	120	34	therapeutic	therapeutic	ADJ
aji-34	120	35	effect	effect	NOUN
aji-34	120	36	on	on	ADP
aji-34	120	37	inflammation	inflammation	NOUN
aji-34	120	38	.	.	PUNCT
aji-34	121	1	as	as	SCONJ
aji-34	121	2	the	the	DET
aji-34	121	3	il-1	il-1	ADP
aji-34	121	4	plays	play	VERB
aji-34	121	5	a	a	DET
aji-34	121	6	critical	critical	ADJ
aji-34	121	7	role	role	NOUN
aji-34	121	8	in	in	ADP
aji-34	121	9	joint	joint	ADJ
aji-34	121	10	damage	damage	NOUN
aji-34	121	11	by	by	ADP
aji-34	121	12	facilitating	facilitate	VERB
aji-34	121	13	the	the	DET
aji-34	121	14	degradation	degradation	NOUN
aji-34	121	15	of	of	ADP
aji-34	121	16	cartilage	cartilage	NOUN
aji-34	121	17	which	which	PRON
aji-34	121	18	leads	lead	VERB
aji-34	121	19	to	to	ADP
aji-34	121	20	ra	ra	PROPN
aji-34	121	21	,	,	PUNCT
aji-34	121	22	the	the	DET
aji-34	121	23	use	use	NOUN
aji-34	121	24	of	of	ADP
aji-34	121	25	interleukin-1	interleukin-1	NOUN
aji-34	121	26	receptor	receptor	NOUN
aji-34	121	27	antagonist	antagonist	NOUN
aji-34	121	28	drugs	drug	NOUN
aji-34	121	29	such	such	ADJ
aji-34	121	30	as	as	ADP
aji-34	121	31	anakinra	anakinra	NOUN
aji-34	121	32	suppresses	suppress	VERB
aji-34	121	33	ra	ra	INTJ
aji-34	121	34	by	by	ADP
aji-34	121	35	inhibiting	inhibit	VERB
aji-34	121	36	the	the	DET
aji-34	121	37	release	release	NOUN
aji-34	121	38	of	of	ADP
aji-34	121	39	il-1	il-1	PRON
aji-34	121	40	,	,	PUNCT
aji-34	121	41	likewise	likewise	ADV
aji-34	121	42	,	,	PUNCT
aji-34	121	43	the	the	DET
aji-34	121	44	use	use	NOUN
aji-34	121	45	of	of	ADP
aji-34	121	46	anti	anti	ADJ
aji-34	121	47	-	-	ADJ
aji-34	121	48	il-6	il-6	ADJ
aji-34	121	49	receptor	receptor	NOUN
aji-34	121	50	agent	agent	NOUN
aji-34	121	51	such	such	ADJ
aji-34	121	52	as	as	ADP
aji-34	121	53	tocilizumab	tocilizumab	NOUN
aji-34	121	54	has	have	AUX
aji-34	121	55	become	become	VERB
aji-34	121	56	a	a	DET
aji-34	121	57	major	major	ADJ
aji-34	121	58	resource	resource	NOUN
aji-34	121	59	for	for	ADP
aji-34	121	60	the	the	DET
aji-34	121	61	treatment	treatment	NOUN
aji-34	121	62	of	of	ADP
aji-34	121	63	ra	ra	PROPN
aji-34	121	64	.	.	PUNCT
aji-34	122	1	keywords	keyword	NOUN
aji-34	122	2	:	:	PUNCT
aji-34	122	3	interleukins	interleukin	VERB
aji-34	122	4	;	;	PUNCT
aji-34	122	5	rheumatoid	rheumatoid	NOUN
aji-34	122	6	arthritis	arthritis	NOUN
aji-34	122	7	;	;	PUNCT
aji-34	122	8	tumor	tumor	NOUN
aji-34	122	9	necrosis	necrosis	NOUN
aji-34	122	10	factor	factor	NOUN
aji-34	122	11	;	;	PUNCT
aji-34	122	12	therapeutics	therapeutic	NOUN
aji-34	122	13	.	.	PUNCT
aji-34	123	1	1	1	X
aji-34	123	2	.	.	X
aji-34	123	3	introduction	introduction	NOUN
aji-34	123	4	the	the	DET
aji-34	123	5	concept	concept	NOUN
aji-34	123	6	of	of	ADP
aji-34	123	7	cytokines	cytokine	NOUN
aji-34	123	8	was	be	AUX
aji-34	123	9	described	describe	VERB
aji-34	123	10	in	in	ADP
aji-34	123	11	1974	1974	NUM
aji-34	123	12	after	after	ADP
aji-34	123	13	the	the	DET
aji-34	123	14	discovery	discovery	NOUN
aji-34	123	15	of	of	ADP
aji-34	123	16	interferon	interferon	NOUN
aji-34	123	17	for	for	ADP
aji-34	123	18	the	the	DET
aji-34	123	19	first	first	ADJ
aji-34	123	20	time	time	NOUN
aji-34	123	21	.	.	PUNCT
aji-34	124	1	cytokines	cytokine	NOUN
aji-34	124	2	are	be	AUX
aji-34	124	3	small	small	ADJ
aji-34	124	4	secreted	secrete	VERB
aji-34	124	5	proteins	protein	NOUN
aji-34	124	6	with	with	ADP
aji-34	124	7	a	a	DET
aji-34	124	8	molecular	molecular	ADJ
aji-34	124	9	weight	weight	NOUN
aji-34	124	10	less	less	ADJ
aji-34	124	11	than	than	ADP
aji-34	124	12	30	30	NUM
aji-34	124	13	kda	kda	NOUN
aji-34	124	14	(	(	PUNCT
aji-34	124	15	˂200	˂200	ADJ
aji-34	124	16	amino	amino	NOUN
aji-34	124	17	acids	acid	NOUN
aji-34	124	18	)	)	PUNCT
aji-34	124	19	that	that	PRON
aji-34	124	20	mediate	mediate	VERB
aji-34	124	21	and	and	CCONJ
aji-34	124	22	regulate	regulate	VERB
aji-34	124	23	immune	immune	ADJ
aji-34	124	24	responses	response	NOUN
aji-34	124	25	,	,	PUNCT
aji-34	124	26	inflammation	inflammation	NOUN
aji-34	124	27	,	,	PUNCT
aji-34	124	28	and	and	CCONJ
aji-34	124	29	hematopoiesis	hematopoiesis	NOUN
aji-34	124	30	they	they	PRON
aji-34	124	31	are	be	AUX
aji-34	124	32	released	release	VERB
aji-34	124	33	by	by	ADP
aji-34	124	34	varieties	variety	NOUN
aji-34	124	35	of	of	ADP
aji-34	124	36	cells	cell	NOUN
aji-34	124	37	such	such	ADJ
aji-34	124	38	as	as	ADP
aji-34	124	39	leukocytes	leukocyte	NOUN
aji-34	124	40	,	,	PUNCT
aji-34	124	41	produced	produce	VERB
aji-34	124	42	de	de	X
aji-34	124	43	novo(starting	novo(starte	VERB
aji-34	124	44	from	from	ADP
aji-34	124	45	the	the	DET
aji-34	124	46	beginning	beginning	NOUN
aji-34	124	47	)	)	PUNCT
aji-34	124	48	in	in	ADP
aji-34	124	49	response	response	NOUN
aji-34	124	50	to	to	ADP
aji-34	124	51	an	an	DET
aji-34	124	52	immune	immune	ADJ
aji-34	124	53	stimulus	stimulus	NOUN
aji-34	124	54	and	and	CCONJ
aji-34	124	55	act	act	VERB
aji-34	124	56	by	by	ADP
aji-34	124	57	binding	bind	VERB
aji-34	124	58	to	to	ADP
aji-34	124	59	the	the	DET
aji-34	124	60	surface	surface	NOUN
aji-34	124	61	membranes	membrane	NOUN
aji-34	124	62	of	of	ADP
aji-34	124	63	target	target	NOUN
aji-34	124	64	cells	cell	NOUN
aji-34	124	65	to	to	PART
aji-34	124	66	evoke	evoke	VERB
aji-34	124	67	a	a	DET
aji-34	124	68	cascade	cascade	NOUN
aji-34	124	69	of	of	ADP
aji-34	124	70	responsive	responsive	ADJ
aji-34	124	71	reactions	reaction	NOUN
aji-34	124	72	[	[	X
aji-34	124	73	1	1	NUM
aji-34	124	74	-	-	SYM
aji-34	124	75	2	2	NUM
aji-34	124	76	]	]	PUNCT
aji-34	124	77	.	.	PUNCT
aji-34	125	1	they	they	PRON
aji-34	125	2	bind	bind	VERB
aji-34	125	3	to	to	ADP
aji-34	125	4	specific	specific	ADJ
aji-34	125	5	receptors	receptor	NOUN
aji-34	125	6	on	on	ADP
aji-34	125	7	target	target	NOUN
aji-34	125	8	cells	cell	NOUN
aji-34	125	9	,	,	PUNCT
aji-34	125	10	triggering	trigger	VERB
aji-34	125	11	signal	signal	NOUN
aji-34	125	12	-	-	PUNCT
aji-34	125	13	transduction	transduction	NOUN
aji-34	125	14	pathways	pathway	NOUN
aji-34	125	15	that	that	PRON
aji-34	125	16	ultimately	ultimately	ADV
aji-34	125	17	alter	alter	VERB
aji-34	125	18	gene	gene	NOUN
aji-34	125	19	expression	expression	NOUN
aji-34	125	20	in	in	ADP
aji-34	125	21	these	these	DET
aji-34	125	22	cells	cell	NOUN
aji-34	125	23	to	to	PART
aji-34	125	24	produce	produce	VERB
aji-34	125	25	cytokines	cytokine	NOUN
aji-34	125	26	that	that	PRON
aji-34	125	27	are	be	AUX
aji-34	125	28	involved	involve	VERB
aji-34	125	29	in	in	ADP
aji-34	125	30	innate	innate	ADJ
aji-34	125	31	,	,	PUNCT
aji-34	125	32	adaptive	adaptive	ADJ
aji-34	125	33	immunity	immunity	NOUN
aji-34	125	34	,	,	PUNCT
aji-34	125	35	the	the	DET
aji-34	125	36	gene	gene	NOUN
aji-34	125	37	products	product	NOUN
aji-34	125	38	(	(	PUNCT
aji-34	125	39	proteins	protein	NOUN
aji-34	125	40	)	)	PUNCT
aji-34	125	41	participate	participate	NOUN
aji-34	125	42	in	in	ADP
aji-34	125	43	the	the	DET
aji-34	125	44	cell	cell	NOUN
aji-34	125	45	proliferation	proliferation	NOUN
aji-34	125	46	,	,	PUNCT
aji-34	125	47	differentiation	differentiation	NOUN
aji-34	125	48	,	,	PUNCT
aji-34	125	49	migration	migration	NOUN
aji-34	125	50	,	,	PUNCT
aji-34	125	51	and	and	CCONJ
aji-34	125	52	apoptosis	apoptosis	NOUN
aji-34	125	53	activities	activity	NOUN
aji-34	125	54	[	[	X
aji-34	125	55	3	3	NUM
aji-34	125	56	-	-	SYM
aji-34	125	57	4	4	NUM
aji-34	125	58	]	]	PUNCT
aji-34	125	59	.	.	PUNCT
aji-34	126	1	to	to	PART
aji-34	126	2	be	be	AUX
aji-34	126	3	more	more	ADV
aji-34	126	4	precise	precise	ADJ
aji-34	126	5	,	,	PUNCT
aji-34	126	6	cytokines	cytokine	NOUN
aji-34	126	7	regulate	regulate	VERB
aji-34	126	8	the	the	DET
aji-34	126	9	intensity	intensity	NOUN
aji-34	126	10	and	and	CCONJ
aji-34	126	11	duration	duration	NOUN
aji-34	126	12	of	of	ADP
aji-34	126	13	the	the	DET
aji-34	126	14	immune	immune	ADJ
aji-34	126	15	response	response	NOUN
aji-34	126	16	by	by	ADP
aji-34	126	17	stimulating	stimulate	VERB
aji-34	126	18	or	or	CCONJ
aji-34	126	19	inhibiting	inhibit	VERB
aji-34	126	20	proliferation	proliferation	NOUN
aji-34	126	21	,	,	PUNCT
aji-34	126	22	differentiation	differentiation	NOUN
aji-34	126	23	,	,	PUNCT
aji-34	126	24	trafficking	trafficking	NOUN
aji-34	126	25	or	or	CCONJ
aji-34	126	26	emigration	emigration	NOUN
aji-34	126	27	of	of	ADP
aji-34	126	28	lymphocytes	lymphocyte	NOUN
aji-34	126	29	all	all	DET
aji-34	126	30	the	the	DET
aji-34	126	31	while	while	NOUN
aji-34	126	32	acting	act	VERB
aji-34	126	33	as	as	ADP
aji-34	126	34	a	a	DET
aji-34	126	35	messenger	messenger	NOUN
aji-34	126	36	for	for	ADP
aji-34	126	37	both	both	DET
aji-34	126	38	arms	arm	NOUN
aji-34	126	39	of	of	ADP
aji-34	126	40	the	the	DET
aji-34	126	41	immune	immune	ADJ
aji-34	126	42	system	system	NOUN
aji-34	126	43	[	[	X
aji-34	126	44	5	5	NUM
aji-34	126	45	]	]	PUNCT
aji-34	126	46	.	.	PUNCT
aji-34	127	1	cytokines	cytokine	NOUN
aji-34	127	2	either	either	CCONJ
aji-34	127	3	stimulate	stimulate	VERB
aji-34	127	4	or	or	CCONJ
aji-34	127	5	suppress	suppress	VERB
aji-34	127	6	the	the	DET
aji-34	127	7	responses	response	NOUN
aji-34	127	8	of	of	ADP
aji-34	127	9	various	various	ADJ
aji-34	127	10	cells	cell	NOUN
aji-34	127	11	involved	involve	VERB
aji-34	127	12	in	in	ADP
aji-34	127	13	host	host	NOUN
aji-34	127	14	immune	immune	ADJ
aji-34	127	15	mechanisms	mechanism	NOUN
aji-34	127	16	,	,	PUNCT
aji-34	127	17	they	they	PRON
aji-34	127	18	assist	assist	VERB
aji-34	127	19	such	such	ADJ
aji-34	127	20	cells	cell	NOUN
aji-34	127	21	to	to	PART
aji-34	127	22	interact	interact	VERB
aji-34	127	23	or	or	CCONJ
aji-34	127	24	convey	convey	VERB
aji-34	127	25	the	the	DET
aji-34	127	26	essential	essential	ADJ
aji-34	127	27	messages	message	NOUN
aji-34	127	28	for	for	ADP
aji-34	127	29	the	the	DET
aji-34	127	30	proper	proper	ADJ
aji-34	127	31	functioning	functioning	NOUN
aji-34	127	32	of	of	ADP
aji-34	127	33	defense	defense	NOUN
aji-34	127	34	systems	system	NOUN
aji-34	127	35	against	against	ADP
aji-34	127	36	numerous	numerous	ADJ
aji-34	127	37	pathogens	pathogen	NOUN
aji-34	127	38	or	or	CCONJ
aji-34	127	39	disease	disease	NOUN
aji-34	127	40	conditions	condition	NOUN
aji-34	127	41	.	.	PUNCT
aji-34	128	1	cytokines	cytokine	NOUN
aji-34	128	2	and	and	CCONJ
aji-34	128	3	their	their	PRON
aji-34	128	4	receptors	receptor	NOUN
aji-34	128	5	exhibit	exhibit	VERB
aji-34	128	6	very	very	ADV
aji-34	128	7	high	high	ADJ
aji-34	128	8	affinity	affinity	NOUN
aji-34	128	9	for	for	ADP
aji-34	128	10	each	each	DET
aji-34	128	11	other	other	ADJ
aji-34	128	12	as	as	ADP
aji-34	128	13	a	a	DET
aji-34	128	14	result	result	NOUN
aji-34	128	15	they	they	PRON
aji-34	128	16	can	can	AUX
aji-34	128	17	exert	exert	VERB
aji-34	128	18	their	their	PRON
aji-34	128	19	biological	biological	ADJ
aji-34	128	20	effects	effect	NOUN
aji-34	128	21	even	even	ADV
aji-34	128	22	at	at	ADP
aji-34	128	23	very	very	ADV
aji-34	128	24	low	low	ADJ
aji-34	128	25	concentrations	concentration	NOUN
aji-34	128	26	[	[	X
aji-34	128	27	6	6	NUM
aji-34	128	28	]	]	PUNCT
aji-34	128	29	.	.	PUNCT
aji-34	129	1	according	accord	VERB
aji-34	129	2	to	to	ADP
aji-34	129	3	the	the	DET
aji-34	129	4	secretion	secretion	NOUN
aji-34	129	5	of	of	ADP
aji-34	129	6	cytokines	cytokine	NOUN
aji-34	129	7	,	,	PUNCT
aji-34	129	8	they	they	PRON
aji-34	129	9	are	be	AUX
aji-34	129	10	classified	classify	VERB
aji-34	129	11	in	in	ADP
aji-34	129	12	table	table	NOUN
aji-34	129	13	1	1	NUM
aji-34	129	14	.	.	NOUN
aji-34	129	15	2	2	NUM
aji-34	129	16	.	.	X
aji-34	129	17	materials	material	NOUN
aji-34	129	18	and	and	CCONJ
aji-34	129	19	methods	method	NOUN
aji-34	129	20	this	this	DET
aji-34	129	21	literature	literature	NOUN
aji-34	129	22	review	review	NOUN
aji-34	129	23	titled	title	VERB
aji-34	129	24	‘	'	PUNCT
aji-34	129	25	role	role	NOUN
aji-34	129	26	of	of	ADP
aji-34	129	27	inflammatory	inflammatory	ADJ
aji-34	129	28	cytokines	cytokine	NOUN
aji-34	129	29	in	in	ADP
aji-34	129	30	the	the	DET
aji-34	129	31	pathogenesis	pathogenesis	NOUN
aji-34	129	32	of	of	ADP
aji-34	129	33	rheumatoid	rheumatoid	NOUN
aji-34	129	34	arthritis	arthritis	NOUN
aji-34	129	35	and	and	CCONJ
aji-34	129	36	novel	novel	ADJ
aji-34	129	37	therapeutic	therapeutic	ADJ
aji-34	129	38	targets	target	NOUN
aji-34	129	39	’’	’'	PUNCT
aji-34	129	40	was	be	AUX
aji-34	129	41	conducted	conduct	VERB
aji-34	129	42	using	use	VERB
aji-34	129	43	online	online	ADJ
aji-34	129	44	database	database	NOUN
aji-34	129	45	of	of	ADP
aji-34	129	46	scientific	scientific	ADJ
aji-34	129	47	collections	collection	NOUN
aji-34	129	48	,	,	PUNCT
aji-34	129	49	key	key	ADJ
aji-34	129	50	articles	article	NOUN
aji-34	129	51	used	use	VERB
aji-34	129	52	were	be	AUX
aji-34	129	53	retrieved	retrieve	VERB
aji-34	129	54	precisely	precisely	ADV
aji-34	129	55	from	from	ADP
aji-34	129	56	ncbi	ncbi	PROPN
aji-34	129	57	(	(	PUNCT
aji-34	129	58	pmc	pmc	PROPN
aji-34	129	59	,	,	PUNCT
aji-34	129	60	pubmed	pubmed	PROPN
aji-34	129	61	)	)	PUNCT
aji-34	129	62	,	,	PUNCT
aji-34	129	63	google	google	PROPN
aji-34	129	64	scholar	scholar	NOUN
aji-34	129	65	,	,	PUNCT
aji-34	129	66	using	use	VERB
aji-34	129	67	the	the	DET
aji-34	129	68	terms	term	NOUN
aji-34	129	69	‘	'	PUNCT
aji-34	129	70	rheumatoid	rheumatoid	NOUN
aji-34	129	71	arthritis	arthritis	NOUN
aji-34	129	72	,	,	PUNCT
aji-34	129	73	cytokines	cytokine	NOUN
aji-34	129	74	,	,	PUNCT
aji-34	129	75	and	and	CCONJ
aji-34	129	76	therapeutics	therapeutic	NOUN
aji-34	129	77	of	of	ADP
aji-34	129	78	rheumatoid	rheumatoid	NOUN
aji-34	129	79	arthritis	arthritis	NOUN
aji-34	129	80	as	as	ADP
aji-34	129	81	keywords	keyword	NOUN
aji-34	129	82	for	for	ADP
aji-34	129	83	our	our	PRON
aji-34	129	84	search	search	NOUN
aji-34	129	85	.	.	PUNCT
aji-34	130	1	we	we	PRON
aji-34	130	2	included	include	VERB
aji-34	130	3	scientific	scientific	ADJ
aji-34	130	4	publications	publication	NOUN
aji-34	130	5	from	from	ADP
aji-34	130	6	december	december	PROPN
aji-34	130	7	2004	2004	NUM
aji-34	130	8	to	to	ADP
aji-34	130	9	november	november	PROPN
aji-34	130	10	2018	2018	NUM
aji-34	130	11	.	.	PUNCT
aji-34	131	1	articles	article	NOUN
aji-34	131	2	focusing	focus	VERB
aji-34	131	3	on	on	ADP
aji-34	131	4	clinical	clinical	ADJ
aji-34	131	5	characteristics	characteristic	NOUN
aji-34	131	6	,	,	PUNCT
aji-34	131	7	epidemiology	epidemiology	NOUN
aji-34	131	8	,	,	PUNCT
aji-34	131	9	pathogenesis	pathogenesis	NOUN
aji-34	131	10	,	,	PUNCT
aji-34	131	11	and	and	CCONJ
aji-34	131	12	treatments	treatment	NOUN
aji-34	131	13	for	for	ADP
aji-34	131	14	rheumatoid	rheumatoid	NOUN
aji-34	131	15	arthritis	arthritis	NOUN
aji-34	131	16	were	be	AUX
aji-34	131	17	eligible	eligible	ADJ
aji-34	131	18	for	for	ADP
aji-34	131	19	inclusion	inclusion	NOUN
aji-34	131	20	.	.	PUNCT
aji-34	132	1	2.1	2.1	NUM
aji-34	132	2	mode	mode	NOUN
aji-34	132	3	of	of	ADP
aji-34	132	4	cytokines	cytokine	NOUN
aji-34	132	5	action	action	NOUN
aji-34	132	6	a	a	DET
aji-34	132	7	particular	particular	ADJ
aji-34	132	8	cytokine	cytokine	NOUN
aji-34	132	9	might	might	AUX
aji-34	132	10	bind	bind	VERB
aji-34	132	11	to	to	ADP
aji-34	132	12	receptors	receptor	NOUN
aji-34	132	13	on	on	ADP
aji-34	132	14	the	the	DET
aji-34	132	15	membrane	membrane	NOUN
aji-34	132	16	of	of	ADP
aji-34	132	17	the	the	DET
aji-34	132	18	same	same	ADJ
aji-34	132	19	cell	cell	NOUN
aji-34	132	20	that	that	PRON
aji-34	132	21	secreted	secrete	VERB
aji-34	132	22	it	it	PRON
aji-34	132	23	and	and	CCONJ
aji-34	132	24	exert	exert	VERB
aji-34	132	25	its	its	PRON
aji-34	132	26	biological	biological	ADJ
aji-34	132	27	effect	effect	NOUN
aji-34	132	28	,	,	PUNCT
aji-34	132	29	a	a	DET
aji-34	132	30	condition	condition	NOUN
aji-34	132	31	which	which	PRON
aji-34	132	32	is	be	AUX
aji-34	132	33	referred	refer	VERB
aji-34	132	34	as	as	ADP
aji-34	132	35	autocrine	autocrine	NOUN
aji-34	132	36	action	action	NOUN
aji-34	132	37	[	[	X
aji-34	132	38	8].it	8].it	NUM
aji-34	132	39	can	can	AUX
aji-34	132	40	also	also	ADV
aji-34	132	41	bind	bind	VERB
aji-34	132	42	to	to	ADP
aji-34	132	43	receptors	receptor	NOUN
aji-34	132	44	on	on	ADP
aji-34	132	45	a	a	DET
aji-34	132	46	target	target	NOUN
aji-34	132	47	cell	cell	NOUN
aji-34	132	48	nearby	nearby	ADV
aji-34	132	49	and	and	CCONJ
aji-34	132	50	exert	exert	VERB
aji-34	132	51	its	its	PRON
aji-34	132	52	biological	biological	ADJ
aji-34	132	53	effect	effect	NOUN
aji-34	132	54	which	which	PRON
aji-34	132	55	is	be	AUX
aji-34	132	56	known	know	VERB
aji-34	132	57	as	as	ADP
aji-34	132	58	paracrine	paracrine	NOUN
aji-34	132	59	table	table	NOUN
aji-34	132	60	1	1	NUM
aji-34	132	61	.	.	PUNCT
aji-34	133	1	shows	show	VERB
aji-34	133	2	different	different	ADJ
aji-34	133	3	classes	class	NOUN
aji-34	133	4	of	of	ADP
aji-34	133	5	cytokine	cytokine	NOUN
aji-34	133	6	and	and	CCONJ
aji-34	133	7	their	their	PRON
aji-34	133	8	function	function	NOUN
aji-34	133	9	chemokine	chemokine	ADJ
aji-34	133	10	function	function	NOUN
aji-34	133	11	ref	ref	NOUN
aji-34	133	12	.	.	PUNCT
aji-34	134	1	lymphokines	lymphokine	NOUN
aji-34	134	2	cytokines	cytokine	VERB
aji-34	134	3	that	that	PRON
aji-34	134	4	are	be	AUX
aji-34	134	5	secreted	secrete	VERB
aji-34	134	6	by	by	ADP
aji-34	134	7	t	t	NOUN
aji-34	134	8	cells	cell	NOUN
aji-34	134	9	and	and	CCONJ
aji-34	134	10	regulate	regulate	VERB
aji-34	134	11	the	the	DET
aji-34	134	12	immune	immune	ADJ
aji-34	134	13	response	response	NOUN
aji-34	135	1	[	[	X
aji-34	135	2	7	7	NUM
aji-34	135	3	]	]	ADJ
aji-34	135	4	proinflammatory	proinflammatory	ADJ
aji-34	135	5	cytokines	cytokine	NOUN
aji-34	135	6	that	that	PRON
aji-34	135	7	amplify	amplify	VERB
aji-34	135	8	and	and	CCONJ
aji-34	135	9	perpetuate	perpetuate	VERB
aji-34	135	10	the	the	DET
aji-34	135	11	inflammatory	inflammatory	ADJ
aji-34	135	12	process	process	NOUN
aji-34	136	1	[	[	X
aji-34	136	2	7	7	NUM
aji-34	136	3	]	]	PUNCT
aji-34	136	4	anti	anti	ADJ
aji-34	136	5	-	-	ADJ
aji-34	136	6	inflammatory	inflammatory	ADJ
aji-34	136	7	cytokines	cytokine	NOUN
aji-34	136	8	that	that	PRON
aji-34	136	9	negatively	negatively	ADV
aji-34	136	10	modulate	modulate	VERB
aji-34	136	11	the	the	DET
aji-34	136	12	inflammatory	inflammatory	ADJ
aji-34	136	13	response	response	NOUN
aji-34	136	14	[	[	X
aji-34	136	15	7	7	NUM
aji-34	136	16	]	]	ADJ
aji-34	136	17	growth	growth	NOUN
aji-34	136	18	factors	factor	NOUN
aji-34	136	19	cytokines	cytokine	NOUN
aji-34	136	20	that	that	PRON
aji-34	136	21	promote	promote	VERB
aji-34	136	22	cell	cell	NOUN
aji-34	136	23	survival	survival	NOUN
aji-34	136	24	and	and	CCONJ
aji-34	136	25	result	result	VERB
aji-34	136	26	in	in	ADP
aji-34	136	27	structural	structural	ADJ
aji-34	136	28	changes	change	NOUN
aji-34	136	29	in	in	ADP
aji-34	136	30	the	the	DET
aji-34	136	31	airways	airway	NOUN
aji-34	137	1	[	[	X
aji-34	137	2	7	7	NUM
aji-34	137	3	]	]	X
aji-34	137	4	chemokine	chemokine	ADJ
aji-34	137	5	cytokines	cytokine	NOUN
aji-34	137	6	which	which	PRON
aji-34	137	7	are	be	AUX
aji-34	137	8	chemotactic	chemotactic	ADJ
aji-34	137	9	for	for	ADP
aji-34	137	10	inflammatory	inflammatory	ADJ
aji-34	137	11	cells	cell	NOUN
aji-34	137	12	[	[	X
aji-34	137	13	7	7	X
aji-34	137	14	]	]	PUNCT
aji-34	137	15	shehu	shehu	NOUN
aji-34	137	16	et	et	PROPN
aji-34	137	17	al	al	PROPN
aji-34	137	18	.	.	PROPN
aji-34	137	19	;	;	PUNCT
aji-34	138	1	aji	aji	PROPN
aji-34	138	2	,	,	PUNCT
aji-34	138	3	3(1	3(1	NUM
aji-34	138	4	):	):	PUNCT
aji-34	138	5	259	259	NUM
aji-34	138	6	-	-	SYM
aji-34	138	7	268	268	NUM
aji-34	138	8	,	,	PUNCT
aji-34	138	9	2020	2020	NUM
aji-34	138	10	;	;	PUNCT
aji-34	138	11	article	article	NOUN
aji-34	138	12	no.aji.57314	no.aji.57314	PROPN
aji-34	138	13	261	261	NUM
aji-34	138	14	action	action	NOUN
aji-34	138	15	[	[	X
aji-34	138	16	8	8	NUM
aji-34	138	17	]	]	PUNCT
aji-34	138	18	.	.	PUNCT
aji-34	139	1	besides	besides	SCONJ
aji-34	139	2	,	,	PUNCT
aji-34	139	3	those	those	DET
aji-34	139	4	cytokines	cytokine	NOUN
aji-34	139	5	which	which	PRON
aji-34	139	6	bind	bind	VERB
aji-34	139	7	to	to	PART
aji-34	139	8	target	target	VERB
aji-34	139	9	cells	cell	NOUN
aji-34	139	10	in	in	ADP
aji-34	139	11	distant	distant	ADJ
aji-34	139	12	locations	location	NOUN
aji-34	139	13	and	and	CCONJ
aji-34	139	14	exert	exert	VERB
aji-34	139	15	their	their	PRON
aji-34	139	16	biological	biological	ADJ
aji-34	139	17	effect	effect	NOUN
aji-34	139	18	are	be	AUX
aji-34	139	19	known	know	VERB
aji-34	139	20	to	to	PART
aji-34	139	21	exert	exert	VERB
aji-34	139	22	endocrine	endocrine	ADJ
aji-34	139	23	mode	mode	NOUN
aji-34	139	24	of	of	ADP
aji-34	139	25	action	action	NOUN
aji-34	139	26	[	[	X
aji-34	139	27	8	8	NUM
aji-34	139	28	]	]	PUNCT
aji-34	139	29	.	.	PUNCT
aji-34	140	1	however	however	ADV
aji-34	140	2	the	the	DET
aji-34	140	3	synergistic	synergistic	ADJ
aji-34	140	4	effect	effect	NOUN
aji-34	140	5	is	be	AUX
aji-34	140	6	seen	see	VERB
aji-34	140	7	when	when	SCONJ
aji-34	140	8	the	the	DET
aji-34	140	9	combined	combined	ADJ
aji-34	140	10	effect	effect	NOUN
aji-34	140	11	of	of	ADP
aji-34	140	12	two	two	NUM
aji-34	140	13	or	or	CCONJ
aji-34	140	14	more	more	ADJ
aji-34	140	15	cytokines	cytokine	NOUN
aji-34	140	16	is	be	AUX
aji-34	140	17	greater	great	ADJ
aji-34	140	18	than	than	ADP
aji-34	140	19	the	the	DET
aji-34	140	20	additive	additive	ADJ
aji-34	140	21	effect	effect	NOUN
aji-34	140	22	of	of	ADP
aji-34	140	23	individual	individual	ADJ
aji-34	140	24	cytokine	cytokine	NOUN
aji-34	141	1	[	[	X
aji-34	141	2	9	9	NUM
aji-34	141	3	]	]	PUNCT
aji-34	141	4	.	.	PUNCT
aji-34	142	1	another	another	DET
aji-34	142	2	mode	mode	NOUN
aji-34	142	3	of	of	ADP
aji-34	142	4	action	action	NOUN
aji-34	142	5	exhibit	exhibit	NOUN
aji-34	142	6	by	by	ADP
aji-34	142	7	cytokine	cytokine	NOUN
aji-34	142	8	is	be	AUX
aji-34	142	9	their	their	PRON
aji-34	142	10	ability	ability	NOUN
aji-34	142	11	to	to	PART
aji-34	142	12	activate	activate	VERB
aji-34	142	13	multiple	multiple	ADJ
aji-34	142	14	signaling	signal	VERB
aji-34	142	15	pathways	pathway	NOUN
aji-34	142	16	thereby	thereby	ADV
aji-34	142	17	affecting	affect	VERB
aji-34	142	18	the	the	DET
aji-34	142	19	activity	activity	NOUN
aji-34	142	20	of	of	ADP
aji-34	142	21	multiple	multiple	ADJ
aji-34	142	22	cells	cell	NOUN
aji-34	142	23	which	which	PRON
aji-34	142	24	is	be	AUX
aji-34	142	25	known	know	VERB
aji-34	142	26	as	as	ADP
aji-34	142	27	pleiotropic	pleiotropic	ADJ
aji-34	142	28	mode	mode	NOUN
aji-34	142	29	of	of	ADP
aji-34	142	30	action	action	NOUN
aji-34	142	31	[	[	X
aji-34	142	32	9	9	NUM
aji-34	142	33	]	]	PUNCT
aji-34	142	34	.	.	PUNCT
aji-34	143	1	besides	besides	ADV
aji-34	143	2	,	,	PUNCT
aji-34	143	3	redundant	redundant	ADJ
aji-34	143	4	mode	mode	NOUN
aji-34	143	5	of	of	ADP
aji-34	143	6	action	action	NOUN
aji-34	143	7	is	be	AUX
aji-34	143	8	also	also	ADV
aji-34	143	9	seen	see	VERB
aji-34	143	10	when	when	SCONJ
aji-34	143	11	multiple	multiple	ADJ
aji-34	143	12	cytokines	cytokine	NOUN
aji-34	143	13	have	have	VERB
aji-34	143	14	the	the	DET
aji-34	143	15	ability	ability	NOUN
aji-34	143	16	to	to	PART
aji-34	143	17	exert	exert	VERB
aji-34	143	18	similar	similar	ADJ
aji-34	143	19	function	function	NOUN
aji-34	143	20	[	[	X
aji-34	143	21	9	9	NUM
aji-34	143	22	]	]	PUNCT
aji-34	143	23	.	.	PUNCT
aji-34	144	1	under	under	ADP
aji-34	144	2	some	some	DET
aji-34	144	3	circumstance	circumstance	NOUN
aji-34	144	4	two	two	NUM
aji-34	144	5	or	or	CCONJ
aji-34	144	6	more	more	ADJ
aji-34	144	7	cytokines	cytokine	NOUN
aji-34	144	8	may	may	AUX
aji-34	144	9	act	act	VERB
aji-34	144	10	on	on	ADP
aji-34	144	11	one	one	NUM
aji-34	144	12	cell	cell	NOUN
aji-34	144	13	and	and	CCONJ
aji-34	144	14	the	the	DET
aji-34	144	15	effect	effect	NOUN
aji-34	144	16	of	of	ADP
aji-34	144	17	one	one	NUM
aji-34	144	18	cytokine	cytokine	NOUN
aji-34	144	19	inhibit	inhibit	NOUN
aji-34	144	20	or	or	CCONJ
aji-34	144	21	offset	offset	VERB
aji-34	144	22	the	the	DET
aji-34	144	23	effects	effect	NOUN
aji-34	144	24	of	of	ADP
aji-34	144	25	another	another	DET
aji-34	144	26	cytokine	cytokine	NOUN
aji-34	144	27	[	[	X
aji-34	144	28	10	10	NUM
aji-34	144	29	]	]	PUNCT
aji-34	144	30	.	.	PUNCT
aji-34	145	1	2.2	2.2	NUM
aji-34	145	2	pro	pro	ADJ
aji-34	145	3	-	-	ADJ
aji-34	145	4	inflammatory	inflammatory	ADJ
aji-34	145	5	cytokines	cytokine	NOUN
aji-34	145	6	pro	pro	ADJ
aji-34	145	7	-	-	ADJ
aji-34	145	8	inflammatory	inflammatory	ADJ
aji-34	145	9	cytokines	cytokine	NOUN
aji-34	145	10	or	or	CCONJ
aji-34	145	11	simply	simply	ADV
aji-34	145	12	inflammatory	inflammatory	ADJ
aji-34	145	13	cytokines	cytokine	NOUN
aji-34	145	14	are	be	AUX
aji-34	145	15	special	special	ADJ
aji-34	145	16	types	type	NOUN
aji-34	145	17	of	of	ADP
aji-34	145	18	signaling	signal	VERB
aji-34	145	19	molecules	molecule	NOUN
aji-34	145	20	that	that	PRON
aji-34	145	21	are	be	AUX
aji-34	145	22	excreted	excrete	VERB
aji-34	145	23	from	from	ADP
aji-34	145	24	immune	immune	ADJ
aji-34	145	25	cells	cell	NOUN
aji-34	145	26	like	like	ADP
aji-34	145	27	t	t	PROPN
aji-34	145	28	helper	helper	NOUN
aji-34	145	29	cells	cell	NOUN
aji-34	145	30	and	and	CCONJ
aji-34	145	31	macrophages	macrophage	NOUN
aji-34	145	32	and	and	CCONJ
aji-34	145	33	certain	certain	ADJ
aji-34	145	34	other	other	ADJ
aji-34	145	35	cells	cell	NOUN
aji-34	145	36	that	that	PRON
aji-34	145	37	promote	promote	VERB
aji-34	145	38	inflammation	inflammation	NOUN
aji-34	145	39	[	[	X
aji-34	145	40	11	11	NUM
aji-34	145	41	]	]	PUNCT
aji-34	145	42	.	.	PUNCT
aji-34	146	1	the	the	DET
aji-34	146	2	most	most	ADV
aji-34	146	3	prominent	prominent	ADJ
aji-34	146	4	among	among	ADP
aji-34	146	5	them	they	PRON
aji-34	146	6	are	be	AUX
aji-34	146	7	interleukins	interleukin	NOUN
aji-34	146	8	(	(	PUNCT
aji-34	146	9	il-1	il-1	X
aji-34	146	10	,	,	PUNCT
aji-34	146	11	il-6	il-6	NUM
aji-34	146	12	)	)	PUNCT
aji-34	146	13	and	and	CCONJ
aji-34	146	14	tumor	tumor	NOUN
aji-34	146	15	necrosis	necrosis	NOUN
aji-34	146	16	factor	factor	NOUN
aji-34	146	17	(	(	PUNCT
aji-34	146	18	tnf	tnf	PROPN
aji-34	146	19	-	-	PUNCT
aji-34	146	20	α	α	PROPN
aji-34	146	21	and	and	CCONJ
aji-34	146	22	tnf	tnf	PROPN
aji-34	146	23	-	-	PUNCT
aji-34	146	24	β	β	NOUN
aji-34	146	25	)	)	PUNCT
aji-34	146	26	which	which	PRON
aji-34	146	27	play	play	VERB
aji-34	146	28	an	an	DET
aji-34	146	29	important	important	ADJ
aji-34	146	30	role	role	NOUN
aji-34	146	31	in	in	ADP
aji-34	146	32	mediating	mediate	VERB
aji-34	146	33	immune	immune	ADJ
aji-34	146	34	response	response	NOUN
aji-34	146	35	,	,	PUNCT
aji-34	146	36	excess	excess	ADJ
aji-34	146	37	production	production	NOUN
aji-34	146	38	of	of	ADP
aji-34	146	39	inflammatory	inflammatory	ADJ
aji-34	146	40	cytokines	cytokine	NOUN
aji-34	146	41	contributes	contribute	VERB
aji-34	146	42	to	to	ADP
aji-34	146	43	inflammatory	inflammatory	ADJ
aji-34	146	44	diseases	disease	NOUN
aji-34	146	45	[	[	X
aji-34	146	46	11	11	NUM
aji-34	146	47	]	]	PUNCT
aji-34	146	48	.	.	PUNCT
aji-34	147	1	inflammatory	inflammatory	ADJ
aji-34	147	2	cytokines	cytokine	NOUN
aji-34	147	3	are	be	AUX
aji-34	147	4	proved	prove	VERB
aji-34	147	5	to	to	PART
aji-34	147	6	be	be	AUX
aji-34	147	7	beneficial	beneficial	ADJ
aji-34	147	8	for	for	ADP
aji-34	147	9	their	their	PRON
aji-34	147	10	bactericidal	bactericidal	ADJ
aji-34	147	11	capacity	capacity	NOUN
aji-34	147	12	of	of	ADP
aji-34	147	13	phagocytes	phagocyte	NOUN
aji-34	147	14	,	,	PUNCT
aji-34	147	15	recruit	recruit	VERB
aji-34	147	16	additional	additional	ADJ
aji-34	147	17	innate	innate	ADJ
aji-34	147	18	cell	cell	NOUN
aji-34	147	19	populations	population	NOUN
aji-34	147	20	to	to	ADP
aji-34	147	21	sites	site	NOUN
aji-34	147	22	of	of	ADP
aji-34	147	23	infection	infection	NOUN
aji-34	147	24	,	,	PUNCT
aji-34	147	25	induce	induce	VERB
aji-34	147	26	dendritic	dendritic	ADJ
aji-34	147	27	cell	cell	NOUN
aji-34	147	28	maturation	maturation	NOUN
aji-34	147	29	and	and	CCONJ
aji-34	147	30	direct	direct	VERB
aji-34	147	31	the	the	DET
aji-34	147	32	subsequent	subsequent	ADJ
aji-34	147	33	specific	specific	ADJ
aji-34	147	34	immune	immune	ADJ
aji-34	147	35	response	response	NOUN
aji-34	147	36	to	to	ADP
aji-34	147	37	the	the	DET
aji-34	147	38	invading	invade	VERB
aji-34	147	39	microbes	microbe	NOUN
aji-34	147	40	[	[	X
aji-34	147	41	12	12	NUM
aji-34	147	42	]	]	PUNCT
aji-34	147	43	.	.	PUNCT
aji-34	148	1	three	three	NUM
aji-34	148	2	pro	pro	ADJ
aji-34	148	3	-	-	ADJ
aji-34	148	4	inflammatory	inflammatory	ADJ
aji-34	148	5	cytokines	cytokine	NOUN
aji-34	148	6	,	,	PUNCT
aji-34	148	7	interleukin-1	interleukin-1	NOUN
aji-34	148	8	,	,	PUNCT
aji-34	148	9	interleukin-6	interleukin-6	NUM
aji-34	148	10	,	,	PUNCT
aji-34	148	11	and	and	CCONJ
aji-34	148	12	tumor	tumor	NOUN
aji-34	148	13	necrosis	necrosis	NOUN
aji-34	148	14	factor	factor	NOUN
aji-34	148	15	-	-	PUNCT
aji-34	148	16	α	α	NOUN
aji-34	148	17	,	,	PUNCT
aji-34	148	18	appear	appear	VERB
aji-34	148	19	to	to	PART
aji-34	148	20	have	have	VERB
aji-34	148	21	a	a	DET
aji-34	148	22	central	central	ADJ
aji-34	148	23	role	role	NOUN
aji-34	148	24	in	in	ADP
aji-34	148	25	tissue	tissue	NOUN
aji-34	148	26	destruction	destruction	NOUN
aji-34	148	27	and	and	CCONJ
aji-34	148	28	are	be	AUX
aji-34	148	29	secreted	secrete	VERB
aji-34	148	30	by	by	ADP
aji-34	148	31	a	a	DET
aji-34	148	32	variety	variety	NOUN
aji-34	148	33	of	of	ADP
aji-34	148	34	cell	cell	NOUN
aji-34	148	35	types	type	NOUN
aji-34	148	36	comprising	comprise	VERB
aji-34	148	37	monocytes	monocyte	NOUN
aji-34	148	38	,	,	PUNCT
aji-34	148	39	macrophages	macrophage	NOUN
aji-34	148	40	,	,	PUNCT
aji-34	148	41	dendritic	dendritic	ADJ
aji-34	148	42	cells	cell	NOUN
aji-34	148	43	,	,	PUNCT
aji-34	148	44	epithelial	epithelial	ADJ
aji-34	148	45	cells	cell	NOUN
aji-34	148	46	,	,	PUNCT
aji-34	148	47	keratinocytes	keratinocyte	NOUN
aji-34	148	48	and	and	CCONJ
aji-34	148	49	fibroblasts	fibroblast	NOUN
aji-34	148	50	[	[	X
aji-34	148	51	12	12	NUM
aji-34	148	52	]	]	PUNCT
aji-34	148	53	.	.	PUNCT
aji-34	149	1	interleukin-1	interleukin-1	NOUN
aji-34	149	2	(	(	PUNCT
aji-34	149	3	il-1	il-1	NUM
aji-34	149	4	)	)	PUNCT
aji-34	149	5	is	be	AUX
aji-34	149	6	one	one	NUM
aji-34	149	7	of	of	ADP
aji-34	149	8	the	the	DET
aji-34	149	9	primary	primary	ADJ
aji-34	149	10	inflammatory	inflammatory	ADJ
aji-34	149	11	cytokines	cytokine	NOUN
aji-34	149	12	that	that	PRON
aji-34	149	13	mediate	mediate	VERB
aji-34	149	14	many	many	ADJ
aji-34	149	15	local	local	ADJ
aji-34	149	16	and	and	CCONJ
aji-34	149	17	systemic	systemic	ADJ
aji-34	149	18	features	feature	NOUN
aji-34	149	19	of	of	ADP
aji-34	149	20	inflammation	inflammation	NOUN
aji-34	149	21	,	,	PUNCT
aji-34	149	22	they	they	PRON
aji-34	149	23	are	be	AUX
aji-34	149	24	made	make	VERB
aji-34	149	25	mainly	mainly	ADV
aji-34	149	26	by	by	ADP
aji-34	149	27	monocytes	monocyte	NOUN
aji-34	149	28	and	and	CCONJ
aji-34	149	29	macrophages	macrophage	NOUN
aji-34	149	30	in	in	ADP
aji-34	149	31	response	response	NOUN
aji-34	149	32	to	to	ADP
aji-34	149	33	a	a	DET
aji-34	149	34	range	range	NOUN
aji-34	149	35	of	of	ADP
aji-34	149	36	stimuli	stimulus	NOUN
aji-34	149	37	including	include	VERB
aji-34	149	38	various	various	ADJ
aji-34	149	39	microbial	microbial	ADJ
aji-34	149	40	products	product	NOUN
aji-34	149	41	,	,	PUNCT
aji-34	149	42	viruses	virus	NOUN
aji-34	149	43	,	,	PUNCT
aji-34	149	44	immune	immune	ADJ
aji-34	149	45	complexes	complex	NOUN
aji-34	149	46	,	,	PUNCT
aji-34	149	47	activated	activate	VERB
aji-34	149	48	t	t	NOUN
aji-34	149	49	cells	cell	NOUN
aji-34	149	50	and	and	CCONJ
aji-34	149	51	combine	combine	VERB
aji-34	149	52	the	the	DET
aji-34	149	53	action	action	NOUN
aji-34	149	54	of	of	ADP
aji-34	149	55	other	other	ADJ
aji-34	149	56	cytokines	cytokine	NOUN
aji-34	149	57	such	such	ADJ
aji-34	149	58	as	as	ADP
aji-34	149	59	interleukin-2	interleukin-2	NOUN
aji-34	149	60	and	and	CCONJ
aji-34	149	61	interferongamma	interferongamma	NOUN
aji-34	150	1	[	[	X
aji-34	150	2	13	13	NUM
aji-34	150	3	]	]	PUNCT
aji-34	150	4	.	.	PUNCT
aji-34	150	5	il-1	il-1	PROPN
aji-34	150	6	exist	exist	VERB
aji-34	150	7	in	in	ADP
aji-34	150	8	two	two	NUM
aji-34	150	9	isoformil-1	isoformil-1	NUM
aji-34	150	10	α	α	NOUN
aji-34	150	11	and	and	CCONJ
aji-34	150	12	β	β	PRON
aji-34	150	13	both	both	PRON
aji-34	150	14	of	of	ADP
aji-34	150	15	which	which	PRON
aji-34	150	16	are	be	AUX
aji-34	150	17	prototypic	prototypic	ADJ
aji-34	150	18	pro	pro	ADJ
aji-34	150	19	-	-	ADJ
aji-34	150	20	inflammatory	inflammatory	ADJ
aji-34	150	21	cytokines	cytokine	NOUN
aji-34	150	22	that	that	PRON
aji-34	150	23	exert	exert	VERB
aji-34	150	24	pleiotropic	pleiotropic	ADJ
aji-34	150	25	effects	effect	NOUN
aji-34	150	26	on	on	ADP
aji-34	150	27	a	a	DET
aji-34	150	28	variety	variety	NOUN
aji-34	150	29	of	of	ADP
aji-34	150	30	cells	cell	NOUN
aji-34	150	31	and	and	CCONJ
aji-34	150	32	play	play	VERB
aji-34	150	33	key	key	ADJ
aji-34	150	34	roles	role	NOUN
aji-34	150	35	in	in	ADP
aji-34	150	36	acute	acute	ADJ
aji-34	150	37	and	and	CCONJ
aji-34	150	38	chronic	chronic	ADJ
aji-34	150	39	inflammatory	inflammatory	ADJ
aji-34	150	40	and	and	CCONJ
aji-34	150	41	autoimmune	autoimmune	ADJ
aji-34	150	42	disorders	disorder	NOUN
aji-34	150	43	[	[	X
aji-34	150	44	13	13	NUM
aji-34	150	45	]	]	PUNCT
aji-34	150	46	.	.	PUNCT
aji-34	151	1	il-1α	il-1α	PROPN
aji-34	151	2	is	be	AUX
aji-34	151	3	a	a	DET
aji-34	151	4	regulator	regulator	NOUN
aji-34	151	5	of	of	ADP
aji-34	151	6	intracellular	intracellular	ADJ
aji-34	151	7	events	event	NOUN
aji-34	151	8	and	and	CCONJ
aji-34	151	9	a	a	DET
aji-34	151	10	local	local	ADJ
aji-34	151	11	inflammatory	inflammatory	ADJ
aji-34	151	12	mediator	mediator	NOUN
aji-34	151	13	,	,	PUNCT
aji-34	151	14	while	while	SCONJ
aji-34	151	15	il-1β	il-1β	PROPN
aji-34	151	16	is	be	AUX
aji-34	151	17	primarily	primarily	ADV
aji-34	151	18	an	an	DET
aji-34	151	19	extracellular	extracellular	ADJ
aji-34	151	20	protein	protein	NOUN
aji-34	151	21	released	release	VERB
aji-34	151	22	from	from	ADP
aji-34	151	23	cells	cell	NOUN
aji-34	151	24	[	[	X
aji-34	151	25	13	13	NUM
aji-34	151	26	]	]	PUNCT
aji-34	151	27	.	.	PUNCT
aji-34	152	1	il-1	il-1	PROPN
aji-34	152	2	also	also	ADV
aji-34	152	3	stimulates	stimulate	VERB
aji-34	152	4	the	the	DET
aji-34	152	5	proliferation	proliferation	NOUN
aji-34	152	6	of	of	ADP
aji-34	152	7	keratinocytes	keratinocyte	NOUN
aji-34	152	8	,	,	PUNCT
aji-34	152	9	fibroblasts	fibroblast	NOUN
aji-34	152	10	and	and	CCONJ
aji-34	152	11	endothelial	endothelial	ADJ
aji-34	152	12	cells	cell	NOUN
aji-34	152	13	of	of	ADP
aji-34	152	14	the	the	DET
aji-34	152	15	tissues	tissue	NOUN
aji-34	152	16	,	,	PUNCT
aji-34	152	17	therefore	therefore	ADV
aji-34	152	18	il-1	il-1	PRON
aji-34	152	19	is	be	AUX
aji-34	152	20	a	a	DET
aji-34	152	21	critical	critical	ADJ
aji-34	152	22	component	component	NOUN
aji-34	152	23	in	in	ADP
aji-34	152	24	the	the	DET
aji-34	152	25	homeostasis	homeostasis	NOUN
aji-34	152	26	of	of	ADP
aji-34	152	27	tissues	tissue	NOUN
aji-34	152	28	and	and	CCONJ
aji-34	152	29	its	its	PRON
aji-34	152	30	unrestricted	unrestricted	ADJ
aji-34	152	31	production	production	NOUN
aji-34	152	32	may	may	AUX
aji-34	152	33	lead	lead	VERB
aji-34	152	34	to	to	ADP
aji-34	152	35	tissue	tissue	NOUN
aji-34	152	36	damage	damage	NOUN
aji-34	152	37	[	[	X
aji-34	152	38	14	14	NUM
aji-34	152	39	]	]	PUNCT
aji-34	152	40	.	.	PUNCT
aji-34	153	1	il-6	il-6	NOUN
aji-34	153	2	is	be	AUX
aji-34	153	3	produced	produce	VERB
aji-34	153	4	locally	locally	ADV
aji-34	153	5	in	in	ADP
aji-34	153	6	the	the	DET
aji-34	153	7	inflamed	inflame	VERB
aji-34	153	8	tissues	tissue	NOUN
aji-34	153	9	following	follow	VERB
aji-34	153	10	cellular	cellular	ADJ
aji-34	153	11	activation	activation	NOUN
aji-34	153	12	by	by	ADP
aji-34	153	13	bacterial	bacterial	ADJ
aji-34	153	14	lipopolysaccharide	lipopolysaccharide	NOUN
aji-34	153	15	or	or	CCONJ
aji-34	153	16	other	other	ADJ
aji-34	153	17	cytokines	cytokine	NOUN
aji-34	153	18	such	such	ADJ
aji-34	153	19	as	as	ADP
aji-34	153	20	il1β	il1β	PROPN
aji-34	153	21	or	or	CCONJ
aji-34	153	22	tnfα	tnfα	NOUN
aji-34	153	23	[	[	X
aji-34	153	24	14	14	NUM
aji-34	153	25	]	]	PUNCT
aji-34	153	26	.	.	PUNCT
aji-34	154	1	there	there	PRON
aji-34	154	2	are	be	VERB
aji-34	154	3	two	two	NUM
aji-34	154	4	il-1	il-1	ADP
aji-34	154	5	receptors	receptor	NOUN
aji-34	154	6	,	,	PUNCT
aji-34	154	7	il-1ri	il-1ri	NOUN
aji-34	154	8	and	and	CCONJ
aji-34	154	9	il-1rii	il-1rii	PROPN
aji-34	154	10	.	.	PUNCT
aji-34	155	1	il-1α	il-1α	PROPN
aji-34	155	2	and	and	CCONJ
aji-34	155	3	il-1β	il-1β	PROPN
aji-34	155	4	signal	signal	VERB
aji-34	155	5	through	through	ADP
aji-34	155	6	il-1ri	il-1ri	NOUN
aji-34	155	7	,	,	PUNCT
aji-34	155	8	binding	bind	VERB
aji-34	155	9	to	to	ADP
aji-34	155	10	il-1rii	il-1rii	PROPN
aji-34	155	11	does	do	AUX
aji-34	155	12	not	not	PART
aji-34	155	13	lead	lead	VERB
aji-34	155	14	to	to	ADP
aji-34	155	15	cell	cell	NOUN
aji-34	155	16	signaling	signal	VERB
aji-34	155	17	and	and	CCONJ
aji-34	155	18	is	be	AUX
aji-34	155	19	therefore	therefore	ADV
aji-34	155	20	considered	consider	VERB
aji-34	155	21	as	as	ADP
aji-34	155	22	a	a	DET
aji-34	155	23	decoy	decoy	NOUN
aji-34	155	24	receptor	receptor	NOUN
aji-34	155	25	,	,	PUNCT
aji-34	155	26	upon	upon	SCONJ
aji-34	155	27	binding	bind	VERB
aji-34	155	28	of	of	ADP
aji-34	155	29	il-1	il-1	ADP
aji-34	155	30	to	to	PART
aji-34	155	31	il-1ri	il-1ri	VERB
aji-34	155	32	,	,	PUNCT
aji-34	155	33	a	a	DET
aji-34	155	34	second	second	ADJ
aji-34	155	35	receptor	receptor	NOUN
aji-34	155	36	termed	term	VERB
aji-34	155	37	il-1	il-1	ADP
aji-34	155	38	receptor	receptor	NOUN
aji-34	155	39	accessory	accessory	NOUN
aji-34	155	40	protein	protein	NOUN
aji-34	155	41	(	(	PUNCT
aji-34	155	42	il1racp	il1racp	NOUN
aji-34	155	43	)	)	PUNCT
aji-34	155	44	gets	get	AUX
aji-34	155	45	recruited	recruit	VERB
aji-34	155	46	at	at	ADP
aji-34	155	47	the	the	DET
aji-34	155	48	cell	cell	NOUN
aji-34	155	49	membrane	membrane	NOUN
aji-34	155	50	to	to	PART
aji-34	155	51	form	form	VERB
aji-34	155	52	a	a	DET
aji-34	155	53	high	high	ADJ
aji-34	155	54	-	-	PUNCT
aji-34	155	55	affinity	affinity	NOUN
aji-34	155	56	binding	bind	VERB
aji-34	155	57	receptor	receptor	NOUN
aji-34	155	58	complex	complex	NOUN
aji-34	155	59	leading	lead	VERB
aji-34	155	60	to	to	ADP
aji-34	155	61	intracellular	intracellular	ADJ
aji-34	155	62	signalling	signal	VERB
aji-34	155	63	[	[	X
aji-34	155	64	15	15	NUM
aji-34	155	65	]	]	X
aji-34	155	66	.	.	PUNCT
aji-34	156	1	a	a	DET
aji-34	156	2	third	third	ADJ
aji-34	156	3	il-1	il-1	ADP
aji-34	156	4	family	family	NOUN
aji-34	156	5	member	member	NOUN
aji-34	156	6	,	,	PUNCT
aji-34	156	7	il-1	il-1	ADP
aji-34	156	8	receptor	receptor	NOUN
aji-34	156	9	antagonist	antagonist	NOUN
aji-34	156	10	(	(	PUNCT
aji-34	156	11	il1ra	il1ra	PROPN
aji-34	156	12	)	)	PUNCT
aji-34	156	13	,	,	PUNCT
aji-34	156	14	binds	bind	VERB
aji-34	156	15	to	to	ADP
aji-34	156	16	il-1	il-1	ADP
aji-34	156	17	receptors	receptor	NOUN
aji-34	156	18	and	and	CCONJ
aji-34	156	19	prevents	prevent	VERB
aji-34	156	20	the	the	DET
aji-34	156	21	interaction	interaction	NOUN
aji-34	156	22	of	of	ADP
aji-34	156	23	il-1	il-1	PUNCT
aji-34	156	24	with	with	ADP
aji-34	156	25	its	its	PRON
aji-34	156	26	receptors	receptor	NOUN
aji-34	156	27	,	,	PUNCT
aji-34	156	28	acting	act	VERB
aji-34	156	29	as	as	ADP
aji-34	156	30	a	a	DET
aji-34	156	31	natural	natural	ADJ
aji-34	156	32	il-1	il-1	ADP
aji-34	156	33	inhibitor.il-1β	inhibitor.il-1β	PROPN
aji-34	156	34	has	have	VERB
aji-34	156	35	important	important	ADJ
aji-34	156	36	homeostatic	homeostatic	ADJ
aji-34	156	37	functions	function	NOUN
aji-34	156	38	in	in	ADP
aji-34	156	39	the	the	DET
aji-34	156	40	normal	normal	ADJ
aji-34	156	41	organism	organism	NOUN
aji-34	156	42	,	,	PUNCT
aji-34	156	43	such	such	ADJ
aji-34	156	44	as	as	ADP
aji-34	156	45	regulation	regulation	NOUN
aji-34	156	46	of	of	ADP
aji-34	156	47	feeding	feeding	NOUN
aji-34	156	48	,	,	PUNCT
aji-34	156	49	sleep	sleep	NOUN
aji-34	156	50	,	,	PUNCT
aji-34	156	51	and	and	CCONJ
aji-34	156	52	temperature	temperature	NOUN
aji-34	156	53	,	,	PUNCT
aji-34	156	54	however	however	ADV
aji-34	156	55	,	,	PUNCT
aji-34	156	56	overproduction	overproduction	NOUN
aji-34	156	57	of	of	ADP
aji-34	156	58	il-1β	il-1β	PROPN
aji-34	156	59	is	be	AUX
aji-34	156	60	implicated	implicate	VERB
aji-34	156	61	in	in	ADP
aji-34	156	62	the	the	DET
aji-34	156	63	pathophysiological	pathophysiological	ADJ
aji-34	156	64	changes	change	NOUN
aji-34	156	65	that	that	PRON
aji-34	156	66	occur	occur	VERB
aji-34	156	67	during	during	ADP
aji-34	156	68	different	different	ADJ
aji-34	156	69	disease	disease	NOUN
aji-34	156	70	states	state	NOUN
aji-34	156	71	such	such	ADJ
aji-34	156	72	as	as	ADP
aji-34	156	73	rheumatoid	rheumatoid	NOUN
aji-34	156	74	arthritis	arthritis	NOUN
aji-34	156	75	,	,	PUNCT
aji-34	156	76	neuropathic	neuropathic	ADJ
aji-34	156	77	pain	pain	NOUN
aji-34	156	78	,	,	PUNCT
aji-34	156	79	inflammatory	inflammatory	ADJ
aji-34	156	80	bowel	bowel	NOUN
aji-34	156	81	disease	disease	NOUN
aji-34	156	82	,	,	PUNCT
aji-34	156	83	osteoarthritis	osteoarthritis	NOUN
aji-34	156	84	,	,	PUNCT
aji-34	156	85	vascular	vascular	ADJ
aji-34	156	86	diseases	disease	NOUN
aji-34	156	87	,	,	PUNCT
aji-34	156	88	multiple	multiple	ADJ
aji-34	156	89	sclerosis	sclerosis	NOUN
aji-34	156	90	,	,	PUNCT
aji-34	156	91	and	and	CCONJ
aji-34	156	92	alzheimer	alzheimer	PROPN
aji-34	156	93	's	's	PART
aji-34	156	94	disease	disease	NOUN
aji-34	156	95	[	[	X
aji-34	156	96	15	15	NUM
aji-34	156	97	]	]	PUNCT
aji-34	156	98	.	.	PUNCT
aji-34	157	1	tumor	tumor	NOUN
aji-34	157	2	necrosis	necrosis	NOUN
aji-34	157	3	factorα	factorα	NOUN
aji-34	157	4	(	(	PUNCT
aji-34	157	5	tnfα	tnfα	NOUN
aji-34	157	6	):	):	PUNCT
aji-34	157	7	is	be	AUX
aji-34	157	8	a	a	DET
aji-34	157	9	proinflammatory	proinflammatory	ADJ
aji-34	157	10	cytokine	cytokine	NOUN
aji-34	157	11	that	that	PRON
aji-34	157	12	possesses	possess	VERB
aji-34	157	13	a	a	DET
aji-34	157	14	wide	wide	ADJ
aji-34	157	15	range	range	NOUN
aji-34	157	16	of	of	ADP
aji-34	157	17	immune	immune	ADJ
aji-34	157	18	regulatory	regulatory	ADJ
aji-34	157	19	functions	function	NOUN
aji-34	157	20	and	and	CCONJ
aji-34	157	21	has	have	VERB
aji-34	157	22	the	the	DET
aji-34	157	23	potential	potential	NOUN
aji-34	157	24	to	to	PART
aji-34	157	25	stimulate	stimulate	VERB
aji-34	157	26	the	the	DET
aji-34	157	27	production	production	NOUN
aji-34	157	28	of	of	ADP
aji-34	157	29	secondary	secondary	ADJ
aji-34	157	30	mediators	mediator	NOUN
aji-34	157	31	,	,	PUNCT
aji-34	157	32	including	include	VERB
aji-34	157	33	chemokine	chemokine	ADJ
aji-34	157	34	or	or	CCONJ
aji-34	157	35	cyclooxygenase	cyclooxygenase	NOUN
aji-34	157	36	products	product	NOUN
aji-34	157	37	,	,	PUNCT
aji-34	157	38	which	which	PRON
aji-34	157	39	amplifies	amplify	VERB
aji-34	157	40	the	the	DET
aji-34	157	41	degree	degree	NOUN
aji-34	157	42	of	of	ADP
aji-34	157	43	inflammation	inflammation	NOUN
aji-34	157	44	[	[	X
aji-34	157	45	16	16	NUM
aji-34	157	46	]	]	PUNCT
aji-34	157	47	.	.	PUNCT
aji-34	158	1	tnf	tnf	PROPN
aji-34	158	2	-	-	PUNCT
aji-34	158	3	α	α	PROPN
aji-34	158	4	was	be	AUX
aji-34	158	5	cloned	clone	VERB
aji-34	158	6	over	over	ADP
aji-34	158	7	2	2	NUM
aji-34	158	8	decades	decade	NOUN
aji-34	158	9	ago	ago	ADV
aji-34	158	10	and	and	CCONJ
aji-34	158	11	its	its	PRON
aji-34	158	12	identification	identification	NOUN
aji-34	158	13	in	in	ADP
aji-34	158	14	part	part	NOUN
aji-34	158	15	led	lead	VERB
aji-34	158	16	to	to	ADP
aji-34	158	17	the	the	DET
aji-34	158	18	discovery	discovery	NOUN
aji-34	158	19	of	of	ADP
aji-34	158	20	a	a	DET
aji-34	158	21	superfamily	superfamily	NOUN
aji-34	158	22	of	of	ADP
aji-34	158	23	tumor	tumor	NOUN
aji-34	158	24	necrosis	necrosis	NOUN
aji-34	158	25	factor	factor	NOUN
aji-34	158	26	(	(	PUNCT
aji-34	158	27	tnfs	tnfs	NOUN
aji-34	158	28	)	)	PUNCT
aji-34	158	29	and	and	CCONJ
aji-34	158	30	their	their	PRON
aji-34	158	31	receptors	receptor	NOUN
aji-34	158	32	[	[	X
aji-34	158	33	17	17	NUM
aji-34	158	34	]	]	PUNCT
aji-34	158	35	.	.	PUNCT
aji-34	159	1	macrophages	macrophage	NOUN
aji-34	159	2	are	be	AUX
aji-34	159	3	major	major	ADJ
aji-34	159	4	producers	producer	NOUN
aji-34	159	5	of	of	ADP
aji-34	159	6	tnfα	tnfα	NOUN
aji-34	159	7	and	and	CCONJ
aji-34	159	8	interestingly	interestingly	ADV
aji-34	159	9	are	be	AUX
aji-34	159	10	also	also	ADV
aji-34	159	11	highly	highly	ADV
aji-34	159	12	responsive	responsive	ADJ
aji-34	159	13	to	to	ADP
aji-34	159	14	tnfα	tnfα	NOUN
aji-34	159	15	,	,	PUNCT
aji-34	159	16	it	it	PRON
aji-34	159	17	signals	signal	VERB
aji-34	159	18	through	through	ADP
aji-34	159	19	two	two	NUM
aji-34	159	20	transmembrane	transmembrane	ADJ
aji-34	159	21	receptors	receptor	NOUN
aji-34	159	22	,	,	PUNCT
aji-34	159	23	tnfr1	tnfr1	NOUN
aji-34	159	24	and	and	CCONJ
aji-34	159	25	tnfr2	tnfr2	VERB
aji-34	159	26	and	and	CCONJ
aji-34	159	27	regulate	regulate	VERB
aji-34	159	28	several	several	ADJ
aji-34	159	29	critical	critical	ADJ
aji-34	159	30	cell	cell	NOUN
aji-34	159	31	functions	function	NOUN
aji-34	159	32	including	include	VERB
aji-34	159	33	cell	cell	NOUN
aji-34	159	34	proliferation	proliferation	NOUN
aji-34	159	35	,	,	PUNCT
aji-34	159	36	survival	survival	NOUN
aji-34	159	37	,	,	PUNCT
aji-34	159	38	differentiation	differentiation	NOUN
aji-34	159	39	and	and	CCONJ
aji-34	159	40	apoptosis	apoptosis	NOUN
aji-34	159	41	[	[	X
aji-34	159	42	17	17	NUM
aji-34	159	43	]	]	PUNCT
aji-34	159	44	.	.	PUNCT
aji-34	160	1	aberrant	aberrant	ADJ
aji-34	160	2	tnfα	tnfα	NOUN
aji-34	160	3	production	production	NOUN
aji-34	160	4	and	and	CCONJ
aji-34	160	5	tnfα	tnfα	NOUN
aji-34	160	6	receptor	receptor	NOUN
aji-34	160	7	signaling	signal	VERB
aji-34	160	8	have	have	AUX
aji-34	160	9	been	be	AUX
aji-34	160	10	associated	associate	VERB
aji-34	160	11	with	with	ADP
aji-34	160	12	the	the	DET
aji-34	160	13	pathogenesis	pathogenesis	NOUN
aji-34	160	14	of	of	ADP
aji-34	160	15	several	several	ADJ
aji-34	160	16	diseases	disease	NOUN
aji-34	160	17	,	,	PUNCT
aji-34	160	18	including	include	VERB
aji-34	160	19	rheumatoid	rheumatoid	NOUN
aji-34	160	20	arthritis	arthritis	NOUN
aji-34	160	21	,	,	PUNCT
aji-34	160	22	crohn	crohn	PROPN
aji-34	160	23	's	's	PART
aji-34	160	24	disease	disease	NOUN
aji-34	160	25	,	,	PUNCT
aji-34	160	26	shehu	shehu	X
aji-34	160	27	et	et	PROPN
aji-34	160	28	al	al	PROPN
aji-34	160	29	.	.	PROPN
aji-34	160	30	;	;	PUNCT
aji-34	160	31	aji	aji	PROPN
aji-34	160	32	,	,	PUNCT
aji-34	160	33	3(1	3(1	NUM
aji-34	160	34	):	):	PUNCT
aji-34	160	35	259	259	NUM
aji-34	160	36	-	-	SYM
aji-34	160	37	268	268	NUM
aji-34	160	38	,	,	PUNCT
aji-34	160	39	2020	2020	NUM
aji-34	160	40	;	;	PUNCT
aji-34	161	1	article	article	NOUN
aji-34	161	2	no.aji.57314	no.aji.57314	NOUN
aji-34	161	3	262	262	NUM
aji-34	161	4	atherosclerosis	atherosclerosis	NOUN
aji-34	161	5	,	,	PUNCT
aji-34	161	6	psoriasis	psoriasis	NOUN
aji-34	161	7	,	,	PUNCT
aji-34	161	8	sepsis	sepsis	NOUN
aji-34	161	9	,	,	PUNCT
aji-34	161	10	diabetes	diabetes	NOUN
aji-34	161	11	and	and	CCONJ
aji-34	161	12	obesity	obesity	NOUN
aji-34	161	13	[	[	X
aji-34	161	14	18	18	NUM
aji-34	161	15	]	]	PUNCT
aji-34	161	16	.	.	PUNCT
aji-34	162	1	tnfα	tnfα	NOUN
aji-34	162	2	has	have	AUX
aji-34	162	3	been	be	AUX
aji-34	162	4	shown	show	VERB
aji-34	162	5	to	to	PART
aji-34	162	6	play	play	VERB
aji-34	162	7	a	a	DET
aji-34	162	8	pivotal	pivotal	ADJ
aji-34	162	9	role	role	NOUN
aji-34	162	10	in	in	ADP
aji-34	162	11	orchestrating	orchestrate	VERB
aji-34	162	12	the	the	DET
aji-34	162	13	cytokine	cytokine	NOUN
aji-34	162	14	cascade	cascade	NOUN
aji-34	162	15	in	in	ADP
aji-34	162	16	many	many	ADJ
aji-34	162	17	inflammatory	inflammatory	ADJ
aji-34	162	18	diseases	disease	NOUN
aji-34	162	19	and	and	CCONJ
aji-34	162	20	because	because	SCONJ
aji-34	162	21	of	of	ADP
aji-34	162	22	this	this	DET
aji-34	162	23	role	role	NOUN
aji-34	162	24	as	as	ADP
aji-34	162	25	a	a	DET
aji-34	162	26	"	"	PUNCT
aji-34	162	27	master	master	NOUN
aji-34	162	28	regulator	regulator	NOUN
aji-34	162	29	"	"	PUNCT
aji-34	162	30	of	of	ADP
aji-34	162	31	inflammatory	inflammatory	ADJ
aji-34	162	32	cytokine	cytokine	NOUN
aji-34	162	33	production	production	NOUN
aji-34	162	34	,	,	PUNCT
aji-34	162	35	it	it	PRON
aji-34	162	36	has	have	AUX
aji-34	162	37	been	be	AUX
aji-34	162	38	proposed	propose	VERB
aji-34	162	39	as	as	ADP
aji-34	162	40	a	a	DET
aji-34	162	41	therapeutic	therapeutic	ADJ
aji-34	162	42	target	target	NOUN
aji-34	162	43	for	for	ADP
aji-34	162	44	several	several	ADJ
aji-34	162	45	diseases	disease	NOUN
aji-34	162	46	[	[	X
aji-34	162	47	19	19	NUM
aji-34	162	48	]	]	PUNCT
aji-34	162	49	.	.	PUNCT
aji-34	163	1	indeed	indeed	ADV
aji-34	163	2	,	,	PUNCT
aji-34	163	3	anti	anti	ADJ
aji-34	163	4	-	-	ADJ
aji-34	163	5	tnfα	tnfα	ADJ
aji-34	163	6	drugs	drug	NOUN
aji-34	163	7	are	be	AUX
aji-34	163	8	now	now	ADV
aji-34	163	9	licensed	license	VERB
aji-34	163	10	for	for	ADP
aji-34	163	11	treating	treat	VERB
aji-34	163	12	certain	certain	ADJ
aji-34	163	13	inflammatory	inflammatory	ADJ
aji-34	163	14	diseases	disease	NOUN
aji-34	163	15	including	include	VERB
aji-34	163	16	rheumatoid	rheumatoid	NOUN
aji-34	163	17	arthritis	arthritis	NOUN
aji-34	163	18	and	and	CCONJ
aji-34	163	19	inflammatory	inflammatory	ADJ
aji-34	163	20	bowel	bowel	NOUN
aji-34	163	21	disease	disease	NOUN
aji-34	163	22	[	[	X
aji-34	163	23	20	20	NUM
aji-34	163	24	]	]	PUNCT
aji-34	163	25	.	.	PUNCT
aji-34	164	1	interleukin	interleukin	NOUN
aji-34	164	2	6	6	NUM
aji-34	164	3	(	(	PUNCT
aji-34	164	4	il-6	il-6	NUM
aji-34	164	5	):	):	PUNCT
aji-34	164	6	is	be	AUX
aji-34	164	7	a	a	DET
aji-34	164	8	pleiotropic	pleiotropic	ADJ
aji-34	164	9	inflammatory	inflammatory	ADJ
aji-34	164	10	cytokine	cytokine	NOUN
aji-34	164	11	synthesized	synthesize	VERB
aji-34	164	12	by	by	ADP
aji-34	164	13	a	a	DET
aji-34	164	14	variety	variety	NOUN
aji-34	164	15	of	of	ADP
aji-34	164	16	cells	cell	NOUN
aji-34	164	17	such	such	ADJ
aji-34	164	18	as	as	ADP
aji-34	164	19	t	t	PROPN
aji-34	164	20	lymphocytes	lymphocyte	NOUN
aji-34	164	21	,	,	PUNCT
aji-34	164	22	macrophages	macrophage	NOUN
aji-34	164	23	,	,	PUNCT
aji-34	164	24	monocytes	monocyte	NOUN
aji-34	164	25	,	,	PUNCT
aji-34	164	26	and	and	CCONJ
aji-34	164	27	synovial	synovial	ADJ
aji-34	164	28	fibroblasts	fibroblast	NOUN
aji-34	164	29	[	[	X
aji-34	164	30	21	21	NUM
aji-34	164	31	]	]	PUNCT
aji-34	164	32	.	.	PUNCT
aji-34	165	1	il-6	il-6	PRON
aji-34	165	2	was	be	AUX
aji-34	165	3	initially	initially	ADV
aji-34	165	4	discovered	discover	VERB
aji-34	165	5	and	and	CCONJ
aji-34	165	6	referred	refer	VERB
aji-34	165	7	as	as	ADP
aji-34	165	8	b	b	NOUN
aji-34	165	9	-	-	PUNCT
aji-34	165	10	cell	cell	NOUN
aji-34	165	11	differentiation	differentiation	NOUN
aji-34	165	12	factor	factor	NOUN
aji-34	165	13	identified	identify	VERB
aji-34	165	14	in	in	ADP
aji-34	165	15	tissue	tissue	NOUN
aji-34	165	16	culture	culture	NOUN
aji-34	165	17	supernatants	supernatant	NOUN
aji-34	165	18	which	which	PRON
aji-34	165	19	induce	induce	VERB
aji-34	165	20	b	b	NOUN
aji-34	165	21	cells	cell	NOUN
aji-34	165	22	to	to	PART
aji-34	165	23	produce	produce	VERB
aji-34	165	24	immune	immune	ADJ
aji-34	165	25	globulins	globulin	NOUN
aji-34	165	26	and	and	CCONJ
aji-34	165	27	involved	involve	VERB
aji-34	165	28	in	in	ADP
aji-34	165	29	diverse	diverse	ADJ
aji-34	165	30	biological	biological	ADJ
aji-34	165	31	functions	function	NOUN
aji-34	165	32	,	,	PUNCT
aji-34	165	33	such	such	ADJ
aji-34	165	34	as	as	ADP
aji-34	165	35	t	t	PROPN
aji-34	165	36	lymphocytes	lymphocyte	NOUN
aji-34	165	37	activation	activation	NOUN
aji-34	165	38	,	,	PUNCT
aji-34	165	39	induction	induction	NOUN
aji-34	165	40	of	of	ADP
aji-34	165	41	acute	acute	ADJ
aji-34	165	42	-	-	PUNCT
aji-34	165	43	phase	phase	NOUN
aji-34	165	44	response	response	NOUN
aji-34	165	45	,	,	PUNCT
aji-34	165	46	growth	growth	NOUN
aji-34	165	47	stimulation	stimulation	NOUN
aji-34	165	48	,	,	PUNCT
aji-34	165	49	differentiation	differentiation	NOUN
aji-34	165	50	of	of	ADP
aji-34	165	51	hematopoietic	hematopoietic	ADJ
aji-34	165	52	precursor	precursor	NOUN
aji-34	165	53	cells	cell	NOUN
aji-34	165	54	and	and	CCONJ
aji-34	165	55	proliferation	proliferation	NOUN
aji-34	165	56	of	of	ADP
aji-34	165	57	synovial	synovial	ADJ
aji-34	165	58	fibroblasts	fibroblast	NOUN
aji-34	165	59	[	[	X
aji-34	165	60	22	22	NUM
aji-34	165	61	]	]	PUNCT
aji-34	165	62	.	.	PUNCT
aji-34	166	1	il-6	il-6	PRON
aji-34	166	2	is	be	AUX
aji-34	166	3	among	among	ADP
aji-34	166	4	the	the	DET
aji-34	166	5	major	major	ADJ
aji-34	166	6	cytokines	cytokine	NOUN
aji-34	166	7	which	which	PRON
aji-34	166	8	contribute	contribute	VERB
aji-34	166	9	to	to	ADP
aji-34	166	10	the	the	DET
aji-34	166	11	progression	progression	NOUN
aji-34	166	12	of	of	ADP
aji-34	166	13	many	many	ADJ
aji-34	166	14	chronic	chronic	ADJ
aji-34	166	15	inflammatory	inflammatory	ADJ
aji-34	166	16	diseases	disease	NOUN
aji-34	166	17	and	and	CCONJ
aji-34	166	18	a	a	DET
aji-34	166	19	wellestablished	wellestablished	ADJ
aji-34	166	20	target	target	NOUN
aji-34	166	21	for	for	ADP
aji-34	166	22	pharmacological	pharmacological	ADJ
aji-34	166	23	intervention	intervention	NOUN
aji-34	166	24	[	[	X
aji-34	166	25	23	23	NUM
aji-34	166	26	-	-	SYM
aji-34	166	27	24	24	NUM
aji-34	166	28	]	]	PUNCT
aji-34	166	29	.	.	PUNCT
aji-34	167	1	mammalian	mammalian	PROPN
aji-34	167	2	il-6	il-6	NOUN
aji-34	167	3	exerts	exert	VERB
aji-34	167	4	its	its	PRON
aji-34	167	5	biological	biological	ADJ
aji-34	167	6	effects	effect	NOUN
aji-34	167	7	by	by	ADP
aji-34	167	8	binding	bind	VERB
aji-34	167	9	to	to	ADP
aji-34	167	10	two	two	NUM
aji-34	167	11	cell	cell	NOUN
aji-34	167	12	surface	surface	NOUN
aji-34	167	13	receptors	receptor	NOUN
aji-34	167	14	,	,	PUNCT
aji-34	167	15	il-6rα	il-6rα	PROPN
aji-34	167	16	and	and	CCONJ
aji-34	167	17	glycoprotein	glycoprotein	VERB
aji-34	167	18	130	130	NUM
aji-34	167	19	receptors	receptor	NOUN
aji-34	167	20	[	[	X
aji-34	167	21	25	25	NUM
aji-34	167	22	-	-	SYM
aji-34	167	23	27	27	NUM
aji-34	167	24	]	]	PUNCT
aji-34	167	25	the	the	DET
aji-34	167	26	assembly	assembly	NOUN
aji-34	167	27	of	of	ADP
aji-34	167	28	the	the	DET
aji-34	167	29	il-6·il-6rα·gp130	il-6·il-6rα·gp130	PROPN
aji-34	167	30	on	on	ADP
aji-34	167	31	the	the	DET
aji-34	167	32	cell	cell	NOUN
aji-34	167	33	surface	surface	NOUN
aji-34	167	34	forming	form	VERB
aji-34	167	35	a	a	DET
aji-34	167	36	complex	complex	NOUN
aji-34	167	37	activates	activate	VERB
aji-34	167	38	the	the	DET
aji-34	167	39	jak	jak	PROPN
aji-34	167	40	family	family	PROPN
aji-34	167	41	of	of	ADP
aji-34	167	42	tyrosine	tyrosine	NOUN
aji-34	167	43	kinases	kinase	NOUN
aji-34	167	44	and	and	CCONJ
aji-34	167	45	the	the	DET
aji-34	167	46	downstream	downstream	ADJ
aji-34	167	47	stat3	stat3	NOUN
aji-34	167	48	transcription	transcription	NOUN
aji-34	167	49	factor	factor	NOUN
aji-34	167	50	[	[	X
aji-34	167	51	28	28	NUM
aji-34	167	52	-	-	SYM
aji-34	167	53	30	30	NUM
aji-34	167	54	]	]	PUNCT
aji-34	167	55	.	.	PUNCT
aji-34	168	1	in	in	ADP
aji-34	168	2	cells	cell	NOUN
aji-34	168	3	that	that	PRON
aji-34	168	4	express	express	VERB
aji-34	168	5	il-6rα	il-6rα	PROPN
aji-34	168	6	,	,	PUNCT
aji-34	168	7	il-6	il-6	NOUN
aji-34	168	8	-	-	PUNCT
aji-34	168	9	dependent	dependent	ADJ
aji-34	168	10	activation	activation	NOUN
aji-34	168	11	of	of	ADP
aji-34	168	12	the	the	DET
aji-34	168	13	signaltransducing	signaltransduce	VERB
aji-34	168	14	gp130	gp130	PROPN
aji-34	168	15	receptor	receptor	NOUN
aji-34	168	16	is	be	AUX
aji-34	168	17	mediated	mediate	VERB
aji-34	168	18	by	by	ADP
aji-34	168	19	membrane	membrane	NOUN
aji-34	168	20	-	-	PUNCT
aji-34	168	21	bound	bind	VERB
aji-34	168	22	il-6rα	il-6rα	PROPN
aji-34	168	23	.	.	PUNCT
aji-34	169	1	alternatively	alternatively	ADV
aji-34	169	2	;	;	PUNCT
aji-34	169	3	il-6	il-6	X
aji-34	169	4	in	in	ADP
aji-34	169	5	a	a	DET
aji-34	169	6	complex	complex	NOUN
aji-34	169	7	with	with	ADP
aji-34	169	8	soluble	soluble	ADJ
aji-34	169	9	il-6rα	il-6rα	PROPN
aji-34	169	10	(	(	PUNCT
aji-34	169	11	sil-6rα	sil-6rα	PROPN
aji-34	169	12	)	)	PUNCT
aji-34	169	13	can	can	AUX
aji-34	169	14	activate	activate	VERB
aji-34	169	15	gp130	gp130	PROPN
aji-34	169	16	in	in	ADP
aji-34	169	17	cells	cell	NOUN
aji-34	169	18	[	[	X
aji-34	169	19	31	31	NUM
aji-34	169	20	]	]	PUNCT
aji-34	169	21	.	.	PUNCT
aji-34	170	1	2.3	2.3	NUM
aji-34	170	2	rheumatoid	rheumatoid	NOUN
aji-34	170	3	arthritis	arthritis	NOUN
aji-34	170	4	rheumatoid	rheumatoid	NOUN
aji-34	170	5	arthritis	arthritis	NOUN
aji-34	170	6	(	(	PUNCT
aji-34	170	7	ra	ra	NOUN
aji-34	170	8	)	)	PUNCT
aji-34	170	9	is	be	AUX
aji-34	170	10	an	an	DET
aji-34	170	11	autoimmune	autoimmune	ADJ
aji-34	170	12	disease	disease	NOUN
aji-34	170	13	that	that	PRON
aji-34	170	14	causes	cause	VERB
aji-34	170	15	chronic	chronic	ADJ
aji-34	170	16	inflammation	inflammation	NOUN
aji-34	170	17	of	of	ADP
aji-34	170	18	the	the	DET
aji-34	170	19	joint	joint	NOUN
aji-34	170	20	.	.	PUNCT
aji-34	171	1	autoimmune	autoimmune	ADJ
aji-34	171	2	diseases	disease	NOUN
aji-34	171	3	are	be	AUX
aji-34	171	4	illnesses	illness	NOUN
aji-34	171	5	that	that	PRON
aji-34	171	6	occur	occur	VERB
aji-34	171	7	when	when	SCONJ
aji-34	171	8	the	the	DET
aji-34	171	9	immune	immune	ADJ
aji-34	171	10	system	system	NOUN
aji-34	171	11	mistakenly	mistakenly	ADV
aji-34	171	12	attacks	attack	VERB
aji-34	171	13	the	the	DET
aji-34	171	14	body	body	NOUN
aji-34	171	15	[	[	X
aji-34	171	16	32	32	NUM
aji-34	171	17	]	]	PUNCT
aji-34	171	18	.	.	PUNCT
aji-34	172	1	the	the	DET
aji-34	172	2	immune	immune	ADJ
aji-34	172	3	system	system	NOUN
aji-34	172	4	contains	contain	VERB
aji-34	172	5	a	a	DET
aji-34	172	6	complex	complex	ADJ
aji-34	172	7	organization	organization	NOUN
aji-34	172	8	of	of	ADP
aji-34	172	9	cells	cell	NOUN
aji-34	172	10	and	and	CCONJ
aji-34	172	11	antibodies	antibodie	VERB
aji-34	172	12	design	design	NOUN
aji-34	172	13	to	to	PART
aji-34	172	14	protect	protect	VERB
aji-34	172	15	the	the	DET
aji-34	172	16	body	body	NOUN
aji-34	172	17	against	against	ADP
aji-34	172	18	infections	infection	NOUN
aji-34	172	19	,	,	PUNCT
aji-34	172	20	one	one	NUM
aji-34	172	21	of	of	ADP
aji-34	172	22	the	the	DET
aji-34	172	23	most	most	ADV
aji-34	172	24	prominent	prominent	ADJ
aji-34	172	25	among	among	ADP
aji-34	172	26	autoimmune	autoimmune	ADJ
aji-34	172	27	diseases	disease	NOUN
aji-34	172	28	is	be	AUX
aji-34	172	29	rheumatoid	rheumatoid	VERB
aji-34	172	30	arthritis	arthritis	NOUN
aji-34	172	31	;	;	PUNCT
aji-34	172	32	also	also	ADV
aji-34	172	33	refer	refer	VERB
aji-34	172	34	to	to	ADP
aji-34	172	35	as	as	ADP
aji-34	172	36	systemic	systemic	ADJ
aji-34	172	37	illness	illness	NOUN
aji-34	172	38	or	or	CCONJ
aji-34	172	39	rheumatoid	rheumatoid	NOUN
aji-34	172	40	disease	disease	NOUN
aji-34	172	41	[	[	X
aji-34	172	42	33	33	NUM
aji-34	172	43	]	]	PUNCT
aji-34	172	44	.	.	PUNCT
aji-34	173	1	the	the	DET
aji-34	173	2	other	other	ADJ
aji-34	173	3	type	type	NOUN
aji-34	173	4	of	of	ADP
aji-34	173	5	rheumatoid	rheumatoid	NOUN
aji-34	173	6	arthritis	arthritis	NOUN
aji-34	173	7	is	be	AUX
aji-34	173	8	juvenile	juvenile	ADJ
aji-34	173	9	idiopathic	idiopathic	ADJ
aji-34	173	10	arthritis	arthritis	NOUN
aji-34	173	11	which	which	PRON
aji-34	173	12	manifests	manifest	VERB
aji-34	173	13	in	in	ADP
aji-34	173	14	individuals	individual	NOUN
aji-34	173	15	less	less	ADJ
aji-34	173	16	than	than	ADP
aji-34	173	17	16	16	NUM
aji-34	173	18	years	year	NOUN
aji-34	173	19	of	of	ADP
aji-34	173	20	age	age	NOUN
aji-34	173	21	[	[	X
aji-34	173	22	33	33	NUM
aji-34	173	23	]	]	PUNCT
aji-34	173	24	.	.	PUNCT
aji-34	174	1	when	when	SCONJ
aji-34	174	2	tissue	tissue	NOUN
aji-34	174	3	inflammation	inflammation	NOUN
aji-34	174	4	occurs	occur	VERB
aji-34	174	5	,	,	PUNCT
aji-34	174	6	the	the	DET
aji-34	174	7	disease	disease	NOUN
aji-34	174	8	is	be	AUX
aji-34	174	9	active	active	ADJ
aji-34	174	10	(	(	PUNCT
aji-34	174	11	relapsed	relapse	VERB
aji-34	174	12	)	)	PUNCT
aji-34	174	13	and	and	CCONJ
aji-34	174	14	the	the	DET
aji-34	174	15	symptoms	symptom	NOUN
aji-34	174	16	include	include	VERB
aji-34	174	17	fatigue	fatigue	NOUN
aji-34	174	18	,	,	PUNCT
aji-34	174	19	loss	loss	NOUN
aji-34	174	20	of	of	ADP
aji-34	174	21	appetite	appetite	NOUN
aji-34	174	22	,	,	PUNCT
aji-34	174	23	muscle	muscle	NOUN
aji-34	174	24	and	and	CCONJ
aji-34	174	25	joint	joint	ADJ
aji-34	174	26	pain	pain	NOUN
aji-34	174	27	,	,	PUNCT
aji-34	174	28	joint	joint	ADJ
aji-34	174	29	redness	redness	NOUN
aji-34	174	30	,	,	PUNCT
aji-34	174	31	joint	joint	ADJ
aji-34	174	32	swelling	swell	VERB
aji-34	174	33	joint	joint	ADJ
aji-34	174	34	tenderness	tenderness	NOUN
aji-34	174	35	rheumatoid	rheumatoid	NOUN
aji-34	174	36	nodules	nodule	NOUN
aji-34	174	37	and	and	CCONJ
aji-34	174	38	finally	finally	ADV
aji-34	174	39	if	if	SCONJ
aji-34	174	40	the	the	DET
aji-34	174	41	symptoms	symptom	NOUN
aji-34	174	42	persist	persist	VERB
aji-34	174	43	it	it	PRON
aji-34	174	44	lead	lead	VERB
aji-34	174	45	to	to	ADP
aji-34	174	46	loss	loss	NOUN
aji-34	174	47	of	of	ADP
aji-34	174	48	joint	joint	ADJ
aji-34	174	49	function	function	NOUN
aji-34	174	50	[	[	X
aji-34	174	51	33	33	NUM
aji-34	174	52	]	]	PUNCT
aji-34	174	53	.	.	PUNCT
aji-34	175	1	when	when	SCONJ
aji-34	175	2	tissue	tissue	NOUN
aji-34	175	3	inflammation	inflammation	NOUN
aji-34	175	4	subsides	subside	VERB
aji-34	175	5	,	,	PUNCT
aji-34	175	6	the	the	DET
aji-34	175	7	disease	disease	NOUN
aji-34	175	8	is	be	AUX
aji-34	175	9	inactive	inactive	ADJ
aji-34	175	10	(	(	PUNCT
aji-34	175	11	remission	remission	NOUN
aji-34	175	12	)	)	PUNCT
aji-34	175	13	,	,	PUNCT
aji-34	175	14	remission	remission	NOUN
aji-34	175	15	may	may	AUX
aji-34	175	16	occur	occur	VERB
aji-34	175	17	spontaneously	spontaneously	ADV
aji-34	175	18	with	with	ADP
aji-34	175	19	treatment	treatment	NOUN
aji-34	175	20	and	and	CCONJ
aji-34	175	21	can	can	AUX
aji-34	175	22	last	last	VERB
aji-34	175	23	for	for	ADP
aji-34	175	24	weeks	week	NOUN
aji-34	175	25	,	,	PUNCT
aji-34	175	26	month	month	NOUN
aji-34	175	27	and	and	CCONJ
aji-34	175	28	years	year	NOUN
aji-34	176	1	[	[	X
aji-34	176	2	33	33	NUM
aji-34	176	3	]	]	PUNCT
aji-34	176	4	.	.	PUNCT
aji-34	177	1	ra	ra	PROPN
aji-34	177	2	targets	target	VERB
aji-34	177	3	synovial	synovial	ADJ
aji-34	177	4	joints	joint	NOUN
aji-34	177	5	and	and	CCONJ
aji-34	177	6	is	be	AUX
aji-34	177	7	often	often	ADV
aji-34	177	8	accompanied	accompany	VERB
aji-34	177	9	by	by	ADP
aji-34	177	10	an	an	DET
aji-34	177	11	array	array	NOUN
aji-34	177	12	of	of	ADP
aji-34	177	13	extra	extra	ADJ
aji-34	177	14	-	-	ADJ
aji-34	177	15	articular	articular	ADJ
aji-34	177	16	manifestations	manifestation	NOUN
aji-34	177	17	which	which	PRON
aji-34	177	18	are	be	AUX
aji-34	177	19	ultimately	ultimately	ADV
aji-34	177	20	major	major	ADJ
aji-34	177	21	predictors	predictor	NOUN
aji-34	177	22	of	of	ADP
aji-34	177	23	increased	increase	VERB
aji-34	177	24	morbidity	morbidity	NOUN
aji-34	177	25	and	and	CCONJ
aji-34	177	26	mortality	mortality	NOUN
aji-34	178	1	[	[	X
aji-34	178	2	34	34	NUM
aji-34	178	3	]	]	PUNCT
aji-34	178	4	.	.	PUNCT
aji-34	179	1	it	it	PRON
aji-34	179	2	was	be	AUX
aji-34	179	3	discovered	discover	VERB
aji-34	179	4	that	that	SCONJ
aji-34	179	5	joint	joint	ADJ
aji-34	179	6	damage	damage	NOUN
aji-34	179	7	occurs	occur	VERB
aji-34	179	8	very	very	ADV
aji-34	179	9	early	early	ADV
aji-34	179	10	in	in	ADP
aji-34	179	11	ra	ra	PROPN
aji-34	179	12	,	,	PUNCT
aji-34	179	13	and	and	CCONJ
aji-34	179	14	after	after	ADP
aji-34	179	15	2	2	NUM
aji-34	179	16	years	year	NOUN
aji-34	179	17	,	,	PUNCT
aji-34	179	18	approximately	approximately	ADV
aji-34	179	19	50	50	NUM
aji-34	179	20	%	%	NOUN
aji-34	179	21	of	of	ADP
aji-34	179	22	patients	patient	NOUN
aji-34	179	23	will	will	AUX
aji-34	179	24	exhibit	exhibit	VERB
aji-34	179	25	bone	bone	NOUN
aji-34	179	26	erosions	erosion	NOUN
aji-34	179	27	[	[	X
aji-34	179	28	35	35	NUM
aji-34	179	29	]	]	PUNCT
aji-34	179	30	.	.	PUNCT
aji-34	180	1	early	early	ADJ
aji-34	180	2	management	management	NOUN
aji-34	180	3	of	of	ADP
aji-34	180	4	rheumatoid	rheumatoid	NOUN
aji-34	180	5	arthritis	arthritis	NOUN
aji-34	180	6	with	with	ADP
aji-34	180	7	disease	disease	NOUN
aji-34	180	8	-	-	PUNCT
aji-34	180	9	modifying	modify	VERB
aji-34	180	10	antirheumatic	antirheumatic	ADJ
aji-34	180	11	drugs	drug	NOUN
aji-34	180	12	(	(	PUNCT
aji-34	180	13	dmards	dmard	NOUN
aji-34	180	14	)	)	PUNCT
aji-34	180	15	is	be	AUX
aji-34	180	16	well	well	ADV
aji-34	180	17	recognized	recognize	VERB
aji-34	180	18	in	in	ADP
aji-34	180	19	regulating	regulate	VERB
aji-34	180	20	the	the	DET
aji-34	180	21	disease	disease	NOUN
aji-34	180	22	severity	severity	NOUN
aji-34	180	23	,	,	PUNCT
aji-34	180	24	until	until	SCONJ
aji-34	180	25	recently	recently	ADV
aji-34	180	26	,	,	PUNCT
aji-34	180	27	treatment	treatment	NOUN
aji-34	180	28	options	option	NOUN
aji-34	180	29	were	be	AUX
aji-34	180	30	limited	limit	VERB
aji-34	180	31	to	to	ADP
aji-34	180	32	single	single	ADJ
aji-34	180	33	or	or	CCONJ
aji-34	180	34	combination	combination	NOUN
aji-34	180	35	therapy	therapy	NOUN
aji-34	180	36	with	with	ADP
aji-34	180	37	a	a	DET
aji-34	180	38	relatively	relatively	ADV
aji-34	180	39	restricted	restricted	ADJ
aji-34	180	40	therapeutic	therapeutic	ADJ
aji-34	180	41	armament	armament	NOUN
aji-34	181	1	[	[	X
aji-34	181	2	36	36	NUM
aji-34	181	3	]	]	PUNCT
aji-34	181	4	.	.	PUNCT
aji-34	182	1	these	these	DET
aji-34	182	2	comprise	comprise	NOUN
aji-34	182	3	of	of	ADP
aji-34	182	4	immunosuppressive	immunosuppressive	ADJ
aji-34	182	5	and	and	CCONJ
aji-34	182	6	dmards	dmards	ADP
aji-34	182	7	such	such	ADJ
aji-34	182	8	as	as	ADP
aji-34	182	9	azathioprine	azathioprine	NOUN
aji-34	182	10	,	,	PUNCT
aji-34	182	11	prednisolone	prednisolone	PROPN
aji-34	182	12	sulfasalazine	sulfasalazine	NOUN
aji-34	182	13	,	,	PUNCT
aji-34	182	14	and	and	CCONJ
aji-34	182	15	methotrexate	methotrexate	VERB
aji-34	183	1	[	[	X
aji-34	183	2	37	37	NUM
aji-34	183	3	]	]	PUNCT
aji-34	183	4	.	.	PUNCT
aji-34	184	1	many	many	ADJ
aji-34	184	2	of	of	ADP
aji-34	184	3	these	these	DET
aji-34	184	4	medications	medication	NOUN
aji-34	184	5	reduce	reduce	VERB
aji-34	184	6	disease	disease	NOUN
aji-34	184	7	activity	activity	NOUN
aji-34	184	8	and	and	CCONJ
aji-34	184	9	block	block	VERB
aji-34	184	10	the	the	DET
aji-34	184	11	radiological	radiological	ADJ
aji-34	184	12	progression	progression	NOUN
aji-34	184	13	of	of	ADP
aji-34	184	14	bone	bone	NOUN
aji-34	184	15	erosion	erosion	NOUN
aji-34	184	16	,	,	PUNCT
aji-34	184	17	judging	judge	VERB
aji-34	184	18	by	by	ADP
aji-34	184	19	the	the	DET
aji-34	184	20	clinical	clinical	ADJ
aji-34	184	21	experience	experience	NOUN
aji-34	184	22	they	they	PRON
aji-34	184	23	are	be	AUX
aji-34	184	24	regarded	regard	VERB
aji-34	184	25	to	to	PART
aji-34	184	26	be	be	AUX
aji-34	184	27	suitable	suitable	ADJ
aji-34	184	28	in	in	ADP
aji-34	184	29	many	many	ADJ
aji-34	184	30	patients	patient	NOUN
aji-34	185	1	[	[	X
aji-34	185	2	38	38	NUM
aji-34	185	3	]	]	PUNCT
aji-34	185	4	.	.	PUNCT
aji-34	186	1	2.4	2.4	NUM
aji-34	186	2	prevalence	prevalence	NOUN
aji-34	186	3	of	of	ADP
aji-34	186	4	rheumatoid	rheumatoid	NOUN
aji-34	186	5	arthritis	arthritis	NOUN
aji-34	186	6	globally	globally	ADV
aji-34	186	7	and	and	CCONJ
aji-34	186	8	in	in	ADP
aji-34	186	9	the	the	DET
aji-34	186	10	us	us	PROPN
aji-34	186	11	ra	ra	PROPN
aji-34	186	12	is	be	AUX
aji-34	186	13	a	a	DET
aji-34	186	14	common	common	ADJ
aji-34	186	15	disease	disease	NOUN
aji-34	186	16	that	that	PRON
aji-34	186	17	affects	affect	VERB
aji-34	186	18	about	about	ADV
aji-34	186	19	1	1	NUM
aji-34	186	20	%	%	NOUN
aji-34	186	21	of	of	ADP
aji-34	186	22	the	the	DET
aji-34	186	23	world	world	NOUN
aji-34	186	24	population	population	NOUN
aji-34	186	25	and	and	CCONJ
aji-34	186	26	about	about	ADV
aji-34	186	27	0.6	0.6	NUM
aji-34	186	28	%	%	NOUN
aji-34	186	29	of	of	ADP
aji-34	186	30	the	the	DET
aji-34	186	31	american	american	ADJ
aji-34	186	32	population	population	NOUN
aji-34	186	33	,	,	PUNCT
aji-34	186	34	many	many	ADJ
aji-34	186	35	adults	adult	NOUN
aji-34	186	36	are	be	AUX
aji-34	186	37	impacted	impact	VERB
aji-34	186	38	by	by	ADP
aji-34	186	39	the	the	DET
aji-34	186	40	condition	condition	NOUN
aji-34	186	41	with	with	ADP
aji-34	186	42	prevalence	prevalence	NOUN
aji-34	186	43	of	of	ADP
aji-34	186	44	0·8–1·0	0·8–1·0	NOUN
aji-34	186	45	%	%	NOUN
aji-34	186	46	and	and	CCONJ
aji-34	186	47	the	the	DET
aji-34	186	48	disease	disease	NOUN
aji-34	186	49	continues	continue	VERB
aji-34	186	50	to	to	PART
aji-34	186	51	cause	cause	VERB
aji-34	186	52	significant	significant	ADJ
aji-34	186	53	morbidity	morbidity	NOUN
aji-34	186	54	and	and	CCONJ
aji-34	186	55	premature	premature	ADJ
aji-34	186	56	mortality	mortality	NOUN
aji-34	187	1	[	[	X
aji-34	187	2	39	39	NUM
aji-34	187	3	]	]	PUNCT
aji-34	187	4	.	.	PUNCT
aji-34	188	1	the	the	DET
aji-34	188	2	annual	annual	ADJ
aji-34	188	3	incidence	incidence	NOUN
aji-34	188	4	of	of	ADP
aji-34	188	5	ra	ra	PROPN
aji-34	188	6	has	have	AUX
aji-34	188	7	been	be	AUX
aji-34	188	8	estimated	estimate	VERB
aji-34	188	9	to	to	ADP
aji-34	188	10	about	about	ADV
aji-34	188	11	40	40	NUM
aji-34	188	12	per	per	ADP
aji-34	188	13	100,000	100,000	NUM
aji-34	188	14	individuals	individual	NOUN
aji-34	188	15	,	,	PUNCT
aji-34	188	16	this	this	PRON
aji-34	188	17	shows	show	VERB
aji-34	188	18	that	that	SCONJ
aji-34	188	19	in	in	ADP
aji-34	188	20	each	each	DET
aji-34	188	21	100,000	100,000	NUM
aji-34	188	22	individuals	individual	NOUN
aji-34	188	23	40	40	NUM
aji-34	188	24	new	new	ADJ
aji-34	188	25	cases	case	NOUN
aji-34	188	26	of	of	ADP
aji-34	188	27	ra	ra	PROPN
aji-34	188	28	are	be	AUX
aji-34	188	29	been	be	AUX
aji-34	188	30	diagnosed	diagnose	VERB
aji-34	188	31	[	[	X
aji-34	188	32	40	40	NUM
aji-34	188	33	]	]	PUNCT
aji-34	188	34	.	.	PUNCT
aji-34	189	1	ra	ra	PROPN
aji-34	189	2	often	often	ADV
aji-34	189	3	initially	initially	ADV
aji-34	189	4	impacts	impact	VERB
aji-34	189	5	many	many	ADJ
aji-34	189	6	children	child	NOUN
aji-34	189	7	and	and	CCONJ
aji-34	189	8	individuals	individual	NOUN
aji-34	189	9	between	between	ADP
aji-34	189	10	30	30	NUM
aji-34	189	11	-	-	SYM
aji-34	189	12	50	50	NUM
aji-34	189	13	years	year	NOUN
aji-34	189	14	of	of	ADP
aji-34	189	15	age	age	NOUN
aji-34	189	16	,	,	PUNCT
aji-34	189	17	surprisingly	surprisingly	ADV
aji-34	189	18	,	,	PUNCT
aji-34	189	19	about	about	ADP
aji-34	189	20	threequarters	threequarter	NOUN
aji-34	189	21	of	of	ADP
aji-34	189	22	all	all	DET
aji-34	189	23	the	the	DET
aji-34	189	24	individuals	individual	NOUN
aji-34	189	25	with	with	ADP
aji-34	189	26	ra	ra	PROPN
aji-34	189	27	are	be	AUX
aji-34	189	28	women	woman	NOUN
aji-34	189	29	[	[	X
aji-34	189	30	41	41	NUM
aji-34	189	31	]	]	PUNCT
aji-34	189	32	.	.	PUNCT
aji-34	190	1	2.5	2.5	NUM
aji-34	190	2	pathogenesis	pathogenesis	NOUN
aji-34	190	3	of	of	ADP
aji-34	190	4	rheumatoid	rheumatoid	NOUN
aji-34	190	5	arthritis	arthritis	NOUN
aji-34	190	6	in	in	ADP
aji-34	190	7	the	the	DET
aji-34	190	8	synovial	synovial	ADJ
aji-34	190	9	joint	joint	NOUN
aji-34	190	10	,	,	PUNCT
aji-34	190	11	there	there	PRON
aji-34	190	12	is	be	VERB
aji-34	190	13	an	an	DET
aji-34	190	14	imbalance	imbalance	NOUN
aji-34	190	15	between	between	ADP
aji-34	190	16	pro	pro	ADJ
aji-34	190	17	-	-	ADJ
aji-34	190	18	inflammatory	inflammatory	ADJ
aji-34	190	19	cytokines	cytokine	NOUN
aji-34	190	20	and	and	CCONJ
aji-34	190	21	anti	anti	ADJ
aji-34	190	22	shehu	shehu	X
aji-34	190	23	et	et	PROPN
aji-34	190	24	al	al	PROPN
aji-34	190	25	.	.	PROPN
aji-34	190	26	;	;	PUNCT
aji-34	190	27	aji	aji	PROPN
aji-34	190	28	,	,	PUNCT
aji-34	190	29	3(1	3(1	NUM
aji-34	190	30	):	):	PUNCT
aji-34	190	31	259	259	NUM
aji-34	190	32	-	-	SYM
aji-34	190	33	268	268	NUM
aji-34	190	34	,	,	PUNCT
aji-34	190	35	2020	2020	NUM
aji-34	190	36	;	;	PUNCT
aji-34	190	37	article	article	NOUN
aji-34	190	38	no.aji.57314	no.aji.57314	PROPN
aji-34	190	39	263	263	NUM
aji-34	190	40	inflammatory	inflammatory	ADJ
aji-34	190	41	cytokines	cytokine	NOUN
aji-34	190	42	[	[	X
aji-34	190	43	42	42	NUM
aji-34	190	44	]	]	PUNCT
aji-34	190	45	.	.	PUNCT
aji-34	191	1	t	t	PROPN
aji-34	191	2	lymphocytes	lymphocyte	NOUN
aji-34	191	3	play	play	VERB
aji-34	191	4	an	an	DET
aji-34	191	5	essential	essential	ADJ
aji-34	191	6	role	role	NOUN
aji-34	191	7	by	by	ADP
aji-34	191	8	the	the	DET
aji-34	191	9	production	production	NOUN
aji-34	191	10	of	of	ADP
aji-34	191	11	various	various	ADJ
aji-34	191	12	cytokines	cytokine	NOUN
aji-34	191	13	with	with	ADP
aji-34	191	14	different	different	ADJ
aji-34	191	15	properties	property	NOUN
aji-34	191	16	which	which	PRON
aji-34	191	17	facilitate	facilitate	VERB
aji-34	191	18	the	the	DET
aji-34	191	19	process	process	NOUN
aji-34	191	20	of	of	ADP
aji-34	191	21	inflammation	inflammation	NOUN
aji-34	191	22	at	at	ADP
aji-34	191	23	the	the	DET
aji-34	191	24	disease	disease	NOUN
aji-34	191	25	state	state	NOUN
aji-34	192	1	[	[	X
aji-34	192	2	42	42	NUM
aji-34	192	3	]	]	PUNCT
aji-34	192	4	.	.	PUNCT
aji-34	193	1	interestingly	interestingly	ADV
aji-34	193	2	,	,	PUNCT
aji-34	193	3	the	the	DET
aji-34	193	4	t	t	PROPN
aji-34	193	5	-	-	PUNCT
aji-34	193	6	helper	helper	NOUN
aji-34	193	7	cells	cell	NOUN
aji-34	193	8	which	which	PRON
aji-34	193	9	have	have	VERB
aji-34	193	10	two	two	NUM
aji-34	193	11	main	main	ADJ
aji-34	193	12	phenotypes	phenotype	NOUN
aji-34	193	13	are	be	AUX
aji-34	193	14	characterized	characterize	VERB
aji-34	193	15	by	by	ADP
aji-34	193	16	two	two	NUM
aji-34	193	17	distinct	distinct	ADJ
aji-34	193	18	cytokine	cytokine	NOUN
aji-34	193	19	profiles	profile	NOUN
aji-34	193	20	namely	namely	ADV
aji-34	193	21	th1	th1	PROPN
aji-34	193	22	and	and	CCONJ
aji-34	193	23	th2	th2	PROPN
aji-34	193	24	along	along	ADP
aji-34	193	25	with	with	ADP
aji-34	193	26	the	the	DET
aji-34	193	27	third	third	ADJ
aji-34	193	28	subset	subset	NOUN
aji-34	193	29	called	call	VERB
aji-34	193	30	th0	th0	PRON
aji-34	193	31	which	which	PRON
aji-34	193	32	is	be	AUX
aji-34	193	33	found	find	VERB
aji-34	193	34	to	to	PART
aji-34	193	35	be	be	AUX
aji-34	193	36	the	the	DET
aji-34	193	37	precursor	precursor	NOUN
aji-34	193	38	of	of	ADP
aji-34	193	39	the	the	DET
aji-34	193	40	two	two	NUM
aji-34	193	41	subsets	subset	NOUN
aji-34	193	42	[	[	X
aji-34	193	43	42	42	NUM
aji-34	193	44	]	]	PUNCT
aji-34	193	45	.	.	PUNCT
aji-34	194	1	th0	th0	PROPN
aji-34	194	2	cytokine	cytokine	NOUN
aji-34	194	3	profile	profile	NOUN
aji-34	194	4	is	be	AUX
aji-34	194	5	intermediate	intermediate	ADJ
aji-34	194	6	,	,	PUNCT
aji-34	194	7	hence	hence	ADV
aji-34	194	8	th1	th1	NOUN
aji-34	194	9	cells	cell	NOUN
aji-34	194	10	significantly	significantly	ADV
aji-34	194	11	intercede	intercede	VERB
aji-34	194	12	the	the	DET
aji-34	194	13	cell	cell	NOUN
aji-34	194	14	-	-	PUNCT
aji-34	194	15	mediated	mediate	VERB
aji-34	194	16	immune	immune	ADJ
aji-34	194	17	response	response	NOUN
aji-34	194	18	(	(	PUNCT
aji-34	194	19	cmi	cmi	NOUN
aji-34	194	20	)	)	PUNCT
aji-34	194	21	while	while	SCONJ
aji-34	194	22	the	the	DET
aji-34	194	23	th2	th2	PROPN
aji-34	194	24	cells	cell	NOUN
aji-34	194	25	intercede	intercede	VERB
aji-34	194	26	the	the	DET
aji-34	194	27	humoral	humoral	ADJ
aji-34	194	28	immune	immune	ADJ
aji-34	194	29	response	response	NOUN
aji-34	194	30	,	,	PUNCT
aji-34	194	31	and	and	CCONJ
aji-34	194	32	these	these	DET
aji-34	194	33	crucial	crucial	ADJ
aji-34	194	34	steps	step	NOUN
aji-34	194	35	determine	determine	VERB
aji-34	194	36	whether	whether	SCONJ
aji-34	194	37	the	the	DET
aji-34	194	38	acquired	acquire	VERB
aji-34	194	39	immune	immune	ADJ
aji-34	194	40	response	response	NOUN
aji-34	194	41	is	be	AUX
aji-34	194	42	dominated	dominate	VERB
aji-34	194	43	by	by	ADP
aji-34	194	44	activation	activation	NOUN
aji-34	194	45	of	of	ADP
aji-34	194	46	macrophage	macrophage	ADJ
aji-34	194	47	,	,	PUNCT
aji-34	194	48	cell	cell	NOUN
aji-34	194	49	mediated	mediate	VERB
aji-34	194	50	immune	immune	ADJ
aji-34	194	51	response	response	NOUN
aji-34	194	52	,	,	PUNCT
aji-34	194	53	pro	pro	ADJ
aji-34	194	54	-	-	ADJ
aji-34	194	55	inflammatory	inflammatory	ADJ
aji-34	194	56	activity	activity	NOUN
aji-34	194	57	of	of	ADP
aji-34	194	58	humoral	humoral	ADJ
aji-34	194	59	immune	immune	ADJ
aji-34	194	60	response	response	NOUN
aji-34	194	61	and	and	CCONJ
aji-34	194	62	anti	anti	ADJ
aji-34	194	63	-	-	ADJ
aji-34	194	64	inflammatory	inflammatory	ADJ
aji-34	194	65	activity	activity	NOUN
aji-34	194	66	[	[	X
aji-34	194	67	42	42	NUM
aji-34	194	68	]	]	PUNCT
aji-34	194	69	.	.	PUNCT
aji-34	195	1	t	t	PROPN
aji-34	195	2	cell	cell	NOUN
aji-34	195	3	-	-	PUNCT
aji-34	195	4	induced	induce	VERB
aji-34	195	5	in	in	ADP
aji-34	195	6	the	the	DET
aji-34	195	7	presence	presence	NOUN
aji-34	195	8	of	of	ADP
aji-34	195	9	tnf	tnf	PROPN
aji-34	195	10	α	α	PROPN
aji-34	195	11	,	,	PUNCT
aji-34	195	12	ifn	ifn	PROPN
aji-34	195	13	-	-	PUNCT
aji-34	195	14	γ	γ	NOUN
aji-34	195	15	,	,	PUNCT
aji-34	195	16	and	and	CCONJ
aji-34	195	17	il-12	il-12	NOUN
aji-34	195	18	develop	develop	VERB
aji-34	195	19	into	into	ADP
aji-34	195	20	th-1	th-1	PRON
aji-34	195	21	type	type	NOUN
aji-34	195	22	of	of	ADP
aji-34	195	23	phenotype	phenotype	NOUN
aji-34	196	1	whereas	whereas	SCONJ
aji-34	196	2	those	those	PRON
aji-34	196	3	induced	induce	VERB
aji-34	196	4	in	in	ADP
aji-34	196	5	the	the	DET
aji-34	196	6	presence	presence	NOUN
aji-34	196	7	of	of	ADP
aji-34	196	8	il-4	il-4	PROPN
aji-34	196	9	,	,	PUNCT
aji-34	196	10	il-6	il-6	NOUN
aji-34	196	11	and	and	CCONJ
aji-34	196	12	il-10develops	il-10develop	NOUN
aji-34	196	13	into	into	ADP
aji-34	196	14	th-2	th-2	DET
aji-34	196	15	phenotype	phenotype	NOUN
aji-34	196	16	[	[	X
aji-34	196	17	43	43	NUM
aji-34	196	18	]	]	PUNCT
aji-34	197	1	.	.	PUNCT
aji-34	198	1	evidence	evidence	NOUN
aji-34	198	2	suggests	suggest	VERB
aji-34	198	3	that	that	SCONJ
aji-34	198	4	interaction	interaction	NOUN
aji-34	198	5	between	between	ADP
aji-34	198	6	an	an	DET
aji-34	198	7	unknown	unknown	ADJ
aji-34	198	8	exogenous	exogenous	NOUN
aji-34	198	9	or	or	CCONJ
aji-34	198	10	endogenous	endogenous	ADJ
aji-34	198	11	antigen	antigen	NOUN
aji-34	198	12	via	via	ADP
aji-34	198	13	antigen	antigen	NOUN
aji-34	198	14	-	-	PUNCT
aji-34	198	15	presenting	present	VERB
aji-34	198	16	cells	cell	NOUN
aji-34	198	17	and	and	CCONJ
aji-34	198	18	cd4	cd4	PROPN
aji-34	198	19	+	+	PROPN
aji-34	198	20	t	t	PROPN
aji-34	198	21	helper	helper	NOUN
aji-34	198	22	cells	cell	NOUN
aji-34	198	23	are	be	AUX
aji-34	198	24	involved	involve	VERB
aji-34	198	25	in	in	ADP
aji-34	198	26	the	the	DET
aji-34	198	27	induction	induction	NOUN
aji-34	198	28	of	of	ADP
aji-34	198	29	inflammation	inflammation	NOUN
aji-34	198	30	in	in	ADP
aji-34	198	31	ra	ra	PROPN
aji-34	199	1	[	[	X
aji-34	199	2	43	43	NUM
aji-34	199	3	]	]	PUNCT
aji-34	199	4	.	.	PUNCT
aji-34	200	1	continuous	continuous	ADJ
aji-34	200	2	recruitment	recruitment	NOUN
aji-34	200	3	and	and	CCONJ
aji-34	200	4	activation	activation	NOUN
aji-34	200	5	of	of	ADP
aji-34	200	6	macrophages	macrophage	NOUN
aji-34	200	7	and	and	CCONJ
aji-34	200	8	monocytes	monocyte	NOUN
aji-34	200	9	occur	occur	VERB
aji-34	200	10	with	with	ADP
aji-34	200	11	the	the	DET
aji-34	200	12	recruitment	recruitment	NOUN
aji-34	200	13	of	of	ADP
aji-34	200	14	pro	pro	ADJ
aji-34	200	15	-	-	ADJ
aji-34	200	16	inflammatory	inflammatory	ADJ
aji-34	200	17	cytokines	cytokine	NOUN
aji-34	200	18	,	,	PUNCT
aji-34	200	19	specifically	specifically	ADV
aji-34	200	20	tnf	tnf	PROPN
aji-34	200	21	-	-	PUNCT
aji-34	200	22	α	α	PROPN
aji-34	200	23	and	and	CCONJ
aji-34	200	24	il-1	il-1	ADP
aji-34	200	25	and	and	CCONJ
aji-34	200	26	il-6	il-6	NOUN
aji-34	200	27	into	into	ADP
aji-34	200	28	the	the	DET
aji-34	200	29	synovial	synovial	ADJ
aji-34	200	30	cavity	cavity	NOUN
aji-34	200	31	,	,	PUNCT
aji-34	200	32	the	the	DET
aji-34	200	33	release	release	NOUN
aji-34	200	34	of	of	ADP
aji-34	200	35	these	these	DET
aji-34	200	36	cytokines	cytokine	NOUN
aji-34	200	37	mediates	mediate	VERB
aji-34	200	38	tissue	tissue	NOUN
aji-34	200	39	destruction	destruction	NOUN
aji-34	200	40	by	by	ADP
aji-34	200	41	activation	activation	NOUN
aji-34	200	42	of	of	ADP
aji-34	200	43	chondrocytes	chondrocyte	NOUN
aji-34	200	44	and	and	CCONJ
aji-34	200	45	fibroblasts	fibroblast	NOUN
aji-34	200	46	which	which	PRON
aji-34	200	47	release	release	VERB
aji-34	200	48	collagenases	collagenase	NOUN
aji-34	200	49	and	and	CCONJ
aji-34	200	50	metalloproteinase	metalloproteinase	NOUN
aji-34	200	51	with	with	ADP
aji-34	200	52	resultant	resultant	NOUN
aji-34	200	53	cartilage	cartilage	NOUN
aji-34	200	54	loss	loss	NOUN
aji-34	200	55	and	and	CCONJ
aji-34	200	56	bone	bone	NOUN
aji-34	200	57	erosion	erosion	NOUN
aji-34	200	58	[	[	X
aji-34	200	59	44	44	NUM
aji-34	200	60	]	]	PUNCT
aji-34	200	61	.	.	PUNCT
aji-34	201	1	these	these	DET
aji-34	201	2	activated	activate	VERB
aji-34	201	3	macrophages	macrophage	NOUN
aji-34	201	4	,	,	PUNCT
aji-34	201	5	monocytes	monocyte	NOUN
aji-34	201	6	,	,	PUNCT
aji-34	201	7	lymphocytes	lymphocyte	NOUN
aji-34	201	8	and	and	CCONJ
aji-34	201	9	fibroblasts	fibroblast	NOUN
aji-34	201	10	,	,	PUNCT
aji-34	201	11	as	as	ADV
aji-34	201	12	well	well	ADV
aji-34	201	13	as	as	ADP
aji-34	201	14	their	their	PRON
aji-34	201	15	product	product	NOUN
aji-34	201	16	,	,	PUNCT
aji-34	201	17	also	also	ADV
aji-34	201	18	stimulate	stimulate	VERB
aji-34	201	19	angiogenesis	angiogenesis	NOUN
aji-34	201	20	,	,	PUNCT
aji-34	201	21	which	which	PRON
aji-34	201	22	explains	explain	VERB
aji-34	201	23	increased	increase	VERB
aji-34	201	24	vascularity	vascularity	NOUN
aji-34	201	25	found	find	VERB
aji-34	201	26	in	in	ADP
aji-34	201	27	the	the	DET
aji-34	201	28	synovium	synovium	NOUN
aji-34	201	29	of	of	ADP
aji-34	201	30	patients	patient	NOUN
aji-34	201	31	with	with	ADP
aji-34	201	32	ra	ra	PROPN
aji-34	202	1	[	[	X
aji-34	202	2	44	44	NUM
aji-34	202	3	]	]	PUNCT
aji-34	202	4	.	.	PUNCT
aji-34	203	1	3	3	X
aji-34	203	2	.	.	X
aji-34	203	3	therapeutic	therapeutic	ADJ
aji-34	203	4	target	target	NOUN
aji-34	203	5	tnf	tnf	PROPN
aji-34	203	6	-	-	PUNCT
aji-34	203	7	α	α	PROPN
aji-34	203	8	blockade	blockade	NOUN
aji-34	203	9	:	:	PUNCT
aji-34	203	10	tnf	tnf	PROPN
aji-34	203	11	-	-	PUNCT
aji-34	203	12	αis	αis	VERB
aji-34	203	13	a	a	DET
aji-34	203	14	potent	potent	ADJ
aji-34	203	15	cytokine	cytokine	NOUN
aji-34	203	16	that	that	PRON
aji-34	203	17	promotes	promote	VERB
aji-34	203	18	inflammation	inflammation	NOUN
aji-34	203	19	by	by	ADP
aji-34	203	20	stimulating	stimulate	VERB
aji-34	203	21	fibroblasts	fibroblast	NOUN
aji-34	203	22	to	to	PART
aji-34	203	23	express	express	VERB
aji-34	203	24	intercellular	intercellular	ADJ
aji-34	203	25	adhesion	adhesion	NOUN
aji-34	203	26	molecules	molecule	NOUN
aji-34	203	27	that	that	PRON
aji-34	203	28	play	play	VERB
aji-34	203	29	a	a	DET
aji-34	203	30	substantial	substantial	ADJ
aji-34	203	31	role	role	NOUN
aji-34	203	32	in	in	ADP
aji-34	203	33	inflammation	inflammation	NOUN
aji-34	203	34	,	,	PUNCT
aji-34	203	35	immune	immune	ADJ
aji-34	203	36	response	response	NOUN
aji-34	203	37	and	and	CCONJ
aji-34	203	38	intracellular	intracellular	ADJ
aji-34	203	39	signalling	signal	VERB
aji-34	203	40	event	event	NOUN
aji-34	203	41	[	[	X
aji-34	203	42	46	46	NUM
aji-34	203	43	]	]	PUNCT
aji-34	203	44	.	.	PUNCT
aji-34	204	1	interaction	interaction	NOUN
aji-34	204	2	of	of	ADP
aji-34	204	3	these	these	DET
aji-34	204	4	adhesion	adhesion	NOUN
aji-34	204	5	molecules	molecule	NOUN
aji-34	204	6	with	with	ADP
aji-34	204	7	their	their	PRON
aji-34	204	8	respective	respective	ADJ
aji-34	204	9	ligands	ligand	NOUN
aji-34	204	10	on	on	ADP
aji-34	204	11	the	the	DET
aji-34	204	12	surface	surface	NOUN
aji-34	204	13	of	of	ADP
aji-34	204	14	leukocytes	leukocyte	NOUN
aji-34	204	15	results	result	NOUN
aji-34	204	16	in	in	ADP
aji-34	204	17	increased	increase	VERB
aji-34	204	18	transport	transport	NOUN
aji-34	204	19	of	of	ADP
aji-34	204	20	leukocytes	leukocyte	NOUN
aji-34	204	21	to	to	ADP
aji-34	204	22	inflammatory	inflammatory	ADJ
aji-34	204	23	sites	site	NOUN
aji-34	204	24	,	,	PUNCT
aji-34	204	25	including	include	VERB
aji-34	204	26	the	the	DET
aji-34	204	27	joints	joint	NOUN
aji-34	204	28	in	in	ADP
aji-34	204	29	patients	patient	NOUN
aji-34	204	30	with	with	ADP
aji-34	204	31	rheumatoid	rheumatoid	NOUN
aji-34	204	32	arthritis	arthritis	NOUN
aji-34	204	33	[	[	X
aji-34	204	34	45	45	NUM
aji-34	204	35	]	]	PUNCT
aji-34	204	36	.	.	PUNCT
aji-34	205	1	tnf	tnf	PROPN
aji-34	205	2	-	-	PUNCT
aji-34	205	3	αindirectly	αindirectly	ADV
aji-34	205	4	down	down	ADJ
aji-34	205	5	-	-	PUNCT
aji-34	205	6	regulates	regulate	VERB
aji-34	205	7	inflammation	inflammation	NOUN
aji-34	205	8	by	by	ADP
aji-34	205	9	stimulating	stimulate	VERB
aji-34	205	10	the	the	DET
aji-34	205	11	release	release	NOUN
aji-34	205	12	of	of	ADP
aji-34	205	13	the	the	DET
aji-34	205	14	corticotrophinreleasing	corticotrophinrelease	VERB
aji-34	205	15	hormone	hormone	NOUN
aji-34	205	16	,	,	PUNCT
aji-34	205	17	this	this	DET
aji-34	205	18	hormone	hormone	NOUN
aji-34	205	19	stimulates	stimulate	VERB
aji-34	205	20	the	the	DET
aji-34	205	21	adrenal	adrenal	ADJ
aji-34	205	22	cortex	cortex	NOUN
aji-34	205	23	to	to	PART
aji-34	205	24	release	release	VERB
aji-34	205	25	cortisol	cortisol	NOUN
aji-34	205	26	,	,	PUNCT
aji-34	205	27	which	which	PRON
aji-34	205	28	inhibits	inhibit	VERB
aji-34	205	29	inflammation	inflammation	NOUN
aji-34	205	30	[	[	X
aji-34	205	31	46	46	NUM
aji-34	205	32	]	]	PUNCT
aji-34	205	33	.	.	PUNCT
aji-34	206	1	as	as	ADP
aji-34	206	2	an	an	DET
aji-34	206	3	inflammatory	inflammatory	ADJ
aji-34	206	4	cytokine	cytokine	NOUN
aji-34	206	5	,	,	PUNCT
aji-34	206	6	tnf	tnf	PROPN
aji-34	206	7	-	-	PUNCT
aji-34	206	8	αhas	αha	VERB
aji-34	206	9	an	an	DET
aji-34	206	10	important	important	ADJ
aji-34	206	11	role	role	NOUN
aji-34	206	12	in	in	ADP
aji-34	206	13	rheumatoid	rheumatoid	PROPN
aji-34	206	14	synovitis	synovitis	PROPN
aji-34	206	15	as	as	SCONJ
aji-34	206	16	studied	study	VERB
aji-34	206	17	in	in	ADP
aji-34	206	18	the	the	DET
aji-34	206	19	culture	culture	NOUN
aji-34	206	20	of	of	ADP
aji-34	206	21	synovial	synovial	ADJ
aji-34	206	22	cells	cell	NOUN
aji-34	206	23	from	from	ADP
aji-34	206	24	patients	patient	NOUN
aji-34	206	25	with	with	ADP
aji-34	206	26	rheumatoid	rheumatoid	NOUN
aji-34	206	27	arthritis	arthritis	NOUN
aji-34	206	28	,	,	PUNCT
aji-34	206	29	by	by	ADP
aji-34	206	30	blocking	block	VERB
aji-34	206	31	the	the	DET
aji-34	206	32	tnf	tnf	PROPN
aji-34	206	33	-	-	PUNCT
aji-34	206	34	αwith	αwith	NOUN
aji-34	206	35	antibodies	antibodie	VERB
aji-34	206	36	significantly	significantly	ADV
aji-34	206	37	fig	fig	NOUN
aji-34	206	38	.	.	PUNCT
aji-34	207	1	1	1	X
aji-34	207	2	.	.	X
aji-34	207	3	ra	ra	PROPN
aji-34	207	4	is	be	AUX
aji-34	207	5	characterized	characterize	VERB
aji-34	207	6	by	by	ADP
aji-34	207	7	proliferative	proliferative	ADJ
aji-34	207	8	synovium	synovium	NOUN
aji-34	207	9	(	(	PUNCT
aji-34	207	10	pannus	pannus	NOUN
aji-34	207	11	)	)	PUNCT
aji-34	207	12	and	and	CCONJ
aji-34	207	13	an	an	DET
aji-34	207	14	excessive	excessive	ADJ
aji-34	207	15	immune	immune	ADJ
aji-34	207	16	response	response	NOUN
aji-34	207	17	of	of	ADP
aji-34	207	18	t	t	PROPN
aji-34	207	19	-	-	PUNCT
aji-34	207	20	cells	cell	NOUN
aji-34	207	21	.	.	PUNCT
aji-34	208	1	pannus	pannus	PROPN
aji-34	208	2	comprises	comprise	VERB
aji-34	208	3	t	t	NOUN
aji-34	208	4	-	-	PUNCT
aji-34	208	5	cells	cell	NOUN
aji-34	208	6	,	,	PUNCT
aji-34	208	7	synovial	synovial	ADJ
aji-34	208	8	fibroblasts	fibroblast	NOUN
aji-34	208	9	,	,	PUNCT
aji-34	208	10	and	and	CCONJ
aji-34	208	11	macrophages	macrophage	NOUN
aji-34	208	12	that	that	PRON
aji-34	208	13	produce	produce	VERB
aji-34	208	14	inflammatory	inflammatory	ADJ
aji-34	208	15	cytokines	cytokine	NOUN
aji-34	208	16	,	,	PUNCT
aji-34	208	17	such	such	ADJ
aji-34	208	18	as	as	ADP
aji-34	208	19	tumor	tumor	NOUN
aji-34	208	20	necrosis	necrosis	NOUN
aji-34	208	21	factor	factor	NOUN
aji-34	208	22	(	(	PUNCT
aji-34	208	23	tnf)-α	tnf)-α	PROPN
aji-34	208	24	,	,	PUNCT
aji-34	208	25	interleukin-1	interleukin-1	NUM
aji-34	208	26	(	(	PUNCT
aji-34	208	27	il-1	il-1	NUM
aji-34	208	28	)	)	PUNCT
aji-34	208	29	,	,	PUNCT
aji-34	208	30	il6	il6	NOUN
aji-34	208	31	,	,	PUNCT
aji-34	208	32	and	and	CCONJ
aji-34	208	33	il-17	il-17	X
aji-34	208	34	.	.	PUNCT
aji-34	209	1	these	these	DET
aji-34	209	2	inflammatory	inflammatory	ADJ
aji-34	209	3	cytokines	cytokine	NOUN
aji-34	209	4	activate	activate	VERB
aji-34	209	5	osteoclasts	osteoclast	NOUN
aji-34	209	6	,	,	PUNCT
aji-34	209	7	leading	lead	VERB
aji-34	209	8	to	to	ADP
aji-34	209	9	bone	bone	NOUN
aji-34	209	10	destruction	destruction	NOUN
aji-34	209	11	[	[	X
aji-34	209	12	45	45	NUM
aji-34	209	13	]	]	PUNCT
aji-34	209	14	shehu	shehu	NOUN
aji-34	209	15	et	et	PROPN
aji-34	209	16	al	al	PROPN
aji-34	209	17	.	.	PROPN
aji-34	209	18	;	;	PUNCT
aji-34	210	1	aji	aji	PROPN
aji-34	210	2	,	,	PUNCT
aji-34	210	3	3(1	3(1	NUM
aji-34	210	4	):	):	PUNCT
aji-34	210	5	259	259	NUM
aji-34	210	6	-	-	SYM
aji-34	210	7	268	268	NUM
aji-34	210	8	,	,	PUNCT
aji-34	210	9	2020	2020	NUM
aji-34	210	10	;	;	PUNCT
aji-34	210	11	article	article	NOUN
aji-34	210	12	no.aji.57314	no.aji.57314	PROPN
aji-34	210	13	264	264	NUM
aji-34	210	14	reduced	reduce	VERB
aji-34	210	15	the	the	DET
aji-34	210	16	production	production	NOUN
aji-34	210	17	of	of	ADP
aji-34	210	18	interleukin-1	interleukin-1	PROPN
aji-34	210	19	,	,	PUNCT
aji-34	210	20	interleukin-6	interleukin-6	NUM
aji-34	210	21	,	,	PUNCT
aji-34	210	22	interleukin-8	interleukin-8	NUM
aji-34	210	23	,	,	PUNCT
aji-34	210	24	and	and	CCONJ
aji-34	210	25	granulocyte	granulocyte	ADJ
aji-34	210	26	–	–	PUNCT
aji-34	210	27	monocyte	monocyte	NOUN
aji-34	210	28	colony	colony	NOUN
aji-34	210	29	-	-	PUNCT
aji-34	210	30	stimulating	stimulate	VERB
aji-34	210	31	factor	factor	NOUN
aji-34	210	32	[	[	X
aji-34	210	33	47	47	NUM
aji-34	210	34	]	]	PUNCT
aji-34	210	35	.	.	PUNCT
aji-34	211	1	thus	thus	ADV
aji-34	211	2	,	,	PUNCT
aji-34	211	3	the	the	DET
aji-34	211	4	blockade	blockade	NOUN
aji-34	211	5	of	of	ADP
aji-34	211	6	tnf	tnf	PROPN
aji-34	211	7	-	-	PUNCT
aji-34	211	8	αhas	αhas	PROPN
aji-34	211	9	a	a	DET
aji-34	211	10	more	more	ADV
aji-34	211	11	precise	precise	ADJ
aji-34	211	12	effect	effect	NOUN
aji-34	211	13	on	on	ADP
aji-34	211	14	inflammation	inflammation	NOUN
aji-34	211	15	than	than	ADP
aji-34	211	16	the	the	DET
aji-34	211	17	blockade	blockade	NOUN
aji-34	211	18	of	of	ADP
aji-34	211	19	other	other	ADJ
aji-34	211	20	cytokines	cytokine	NOUN
aji-34	211	21	present	present	ADJ
aji-34	211	22	in	in	ADP
aji-34	211	23	high	high	ADJ
aji-34	211	24	concentrations	concentration	NOUN
aji-34	211	25	in	in	ADP
aji-34	211	26	the	the	DET
aji-34	211	27	synovial	synovial	ADJ
aji-34	211	28	membrane	membrane	NOUN
aji-34	211	29	,	,	PUNCT
aji-34	211	30	such	such	ADJ
aji-34	211	31	as	as	ADP
aji-34	211	32	interleukin-1	interleukin-1	NUM
aji-34	211	33	[	[	X
aji-34	211	34	48	48	NUM
aji-34	211	35	]	]	PUNCT
aji-34	211	36	.	.	PUNCT
aji-34	212	1	the	the	DET
aji-34	212	2	result	result	NOUN
aji-34	212	3	of	of	ADP
aji-34	212	4	studies	study	NOUN
aji-34	212	5	in	in	ADP
aji-34	212	6	the	the	DET
aji-34	212	7	animal	animal	NOUN
aji-34	212	8	model	model	NOUN
aji-34	212	9	shows	show	VERB
aji-34	212	10	the	the	DET
aji-34	212	11	importance	importance	NOUN
aji-34	212	12	of	of	ADP
aji-34	212	13	tnf	tnf	PROPN
aji-34	212	14	-	-	PUNCT
aji-34	212	15	αin	αin	NOUN
aji-34	212	16	rheumatoid	rheumatoid	NOUN
aji-34	212	17	arthritis	arthritis	NOUN
aji-34	212	18	,	,	PUNCT
aji-34	212	19	in	in	ADP
aji-34	212	20	transgenic	transgenic	NOUN
aji-34	212	21	mice	mouse	NOUN
aji-34	212	22	that	that	PRON
aji-34	212	23	expressed	express	VERB
aji-34	212	24	a	a	DET
aji-34	212	25	deregulated	deregulated	ADJ
aji-34	212	26	human	human	ADJ
aji-34	212	27	tnf	tnf	PROPN
aji-34	212	28	-	-	PUNCT
aji-34	212	29	αgene	αgene	NOUN
aji-34	212	30	,	,	PUNCT
aji-34	212	31	there	there	PRON
aji-34	212	32	is	be	VERB
aji-34	212	33	the	the	DET
aji-34	212	34	spontaneous	spontaneous	ADJ
aji-34	212	35	development	development	NOUN
aji-34	212	36	of	of	ADP
aji-34	212	37	polyarthritis	polyarthritis	NOUN
aji-34	212	38	which	which	PRON
aji-34	212	39	is	be	AUX
aji-34	212	40	another	another	DET
aji-34	212	41	form	form	NOUN
aji-34	212	42	of	of	ADP
aji-34	212	43	arthritis	arthritis	NOUN
aji-34	212	44	that	that	PRON
aji-34	212	45	affects	affect	VERB
aji-34	212	46	many	many	ADJ
aji-34	212	47	joints	joint	NOUN
aji-34	212	48	,	,	PUNCT
aji-34	212	49	and	and	CCONJ
aji-34	212	50	however	however	ADV
aji-34	212	51	first	first	ADJ
aji-34	212	52	aid	aid	NOUN
aji-34	212	53	treatment	treatment	NOUN
aji-34	212	54	of	of	ADP
aji-34	212	55	these	these	DET
aji-34	212	56	animals	animal	NOUN
aji-34	212	57	with	with	ADP
aji-34	212	58	a	a	DET
aji-34	212	59	monoclonal	monoclonal	NOUN
aji-34	212	60	antibody	antibody	NOUN
aji-34	212	61	against	against	ADP
aji-34	212	62	tnf	tnf	PROPN
aji-34	212	63	-	-	PUNCT
aji-34	212	64	αprevents	αprevent	NOUN
aji-34	212	65	the	the	DET
aji-34	212	66	development	development	NOUN
aji-34	212	67	of	of	ADP
aji-34	212	68	ra	ra	PROPN
aji-34	213	1	[	[	X
aji-34	213	2	49	49	NUM
aji-34	213	3	]	]	PUNCT
aji-34	213	4	.	.	PUNCT
aji-34	214	1	interleukin-1	interleukin-1	NOUN
aji-34	214	2	receptor	receptor	NOUN
aji-34	214	3	antagonist	antagonist	NOUN
aji-34	214	4	:	:	PUNCT
aji-34	214	5	the	the	DET
aji-34	214	6	il-1	il-1	ADP
aji-34	214	7	receptor	receptor	NOUN
aji-34	214	8	antagonist	antagonist	NOUN
aji-34	214	9	(	(	PUNCT
aji-34	214	10	il-1ra	il-1ra	NOUN
aji-34	214	11	)	)	PUNCT
aji-34	214	12	is	be	AUX
aji-34	214	13	an	an	DET
aji-34	214	14	endogenous	endogenous	ADJ
aji-34	214	15	ligand	ligand	NOUN
aji-34	214	16	that	that	PRON
aji-34	214	17	binds	bind	VERB
aji-34	214	18	the	the	DET
aji-34	214	19	interleukin-1	interleukin-1	NUM
aji-34	214	20	receptor	receptor	NOUN
aji-34	214	21	(	(	PUNCT
aji-34	214	22	il1r	il1r	PROPN
aji-34	214	23	)	)	PUNCT
aji-34	214	24	without	without	ADP
aji-34	214	25	recruiting	recruit	VERB
aji-34	214	26	the	the	DET
aji-34	214	27	interleukin-1	interleukin-1	NUM
aji-34	214	28	receptor	receptor	NOUN
aji-34	214	29	accessory	accessory	NOUN
aji-34	214	30	protein	protein	NOUN
aji-34	214	31	(	(	PUNCT
aji-34	214	32	il1	il1	NOUN
aji-34	214	33	-	-	NOUN
aji-34	214	34	racp	racp	NOUN
aji-34	214	35	)	)	PUNCT
aji-34	214	36	to	to	PART
aji-34	214	37	hinder	hinder	VERB
aji-34	214	38	the	the	DET
aji-34	214	39	activation	activation	NOUN
aji-34	214	40	of	of	ADP
aji-34	214	41	the	the	DET
aji-34	214	42	receptor	receptor	NOUN
aji-34	214	43	,	,	PUNCT
aji-34	214	44	il-1ra	il-1ra	NOUN
aji-34	214	45	has	have	VERB
aji-34	214	46	a	a	DET
aji-34	214	47	higher	high	ADJ
aji-34	214	48	affinity	affinity	NOUN
aji-34	214	49	for	for	ADP
aji-34	214	50	the	the	DET
aji-34	214	51	il-1r	il-1r	NOUN
aji-34	214	52	than	than	ADP
aji-34	214	53	il-1α	il-1α	PROPN
aji-34	214	54	or	or	CCONJ
aji-34	214	55	il-1β	il-1β	PROPN
aji-34	214	56	and	and	CCONJ
aji-34	214	57	serves	serve	VERB
aji-34	214	58	to	to	PART
aji-34	214	59	regulate	regulate	VERB
aji-34	214	60	the	the	DET
aji-34	214	61	signaling	signaling	NOUN
aji-34	214	62	of	of	ADP
aji-34	214	63	il-1	il-1	NUM
aji-34	214	64	by	by	ADP
aji-34	214	65	preventing	prevent	VERB
aji-34	214	66	the	the	DET
aji-34	214	67	binding	binding	NOUN
aji-34	214	68	of	of	ADP
aji-34	214	69	other	other	ADJ
aji-34	214	70	active	active	ADJ
aji-34	214	71	cytokines	cytokine	NOUN
aji-34	215	1	[	[	X
aji-34	215	2	51	51	NUM
aji-34	215	3	]	]	PUNCT
aji-34	215	4	.	.	PUNCT
aji-34	216	1	deficiency	deficiency	NOUN
aji-34	216	2	of	of	ADP
aji-34	216	3	il-1ra	il-1ra	ADJ
aji-34	216	4	results	result	NOUN
aji-34	216	5	in	in	ADP
aji-34	216	6	a	a	DET
aji-34	216	7	reduction	reduction	NOUN
aji-34	216	8	of	of	ADP
aji-34	216	9	regulatory	regulatory	ADJ
aji-34	216	10	function	function	NOUN
aji-34	216	11	and	and	CCONJ
aji-34	216	12	can	can	AUX
aji-34	216	13	lead	lead	VERB
aji-34	216	14	to	to	ADP
aji-34	216	15	severe	severe	ADJ
aji-34	216	16	inflammation	inflammation	NOUN
aji-34	216	17	and	and	CCONJ
aji-34	216	18	auto	auto	NOUN
aji-34	216	19	inflammatory	inflammatory	ADJ
aji-34	216	20	disorders	disorder	NOUN
aji-34	216	21	such	such	ADJ
aji-34	216	22	as	as	ADP
aji-34	216	23	arthritis	arthritis	NOUN
aji-34	216	24	,	,	PUNCT
aji-34	216	25	vasculitis	vasculitis	NOUN
aji-34	216	26	,	,	PUNCT
aji-34	216	27	and	and	CCONJ
aji-34	216	28	skin	skin	NOUN
aji-34	216	29	lesions	lesion	NOUN
aji-34	216	30	in	in	ADP
aji-34	216	31	humans	human	NOUN
aji-34	216	32	[	[	X
aji-34	216	33	52	52	NUM
aji-34	216	34	]	]	PUNCT
aji-34	216	35	.	.	PUNCT
aji-34	217	1	il-1	il-1	PUNCT
aji-34	217	2	binds	bind	VERB
aji-34	217	3	to	to	ADP
aji-34	217	4	two	two	NUM
aji-34	217	5	types	type	NOUN
aji-34	217	6	of	of	ADP
aji-34	217	7	cellsurface	cellsurface	NOUN
aji-34	217	8	receptors	receptor	NOUN
aji-34	217	9	,	,	PUNCT
aji-34	217	10	type	type	NOUN
aji-34	217	11	i	i	PRON
aji-34	217	12	receptors	receptor	NOUN
aji-34	217	13	are	be	AUX
aji-34	217	14	found	find	VERB
aji-34	217	15	on	on	ADP
aji-34	217	16	many	many	ADJ
aji-34	217	17	cells	cell	NOUN
aji-34	217	18	in	in	ADP
aji-34	217	19	trace	trace	NOUN
aji-34	217	20	amount	amount	NOUN
aji-34	217	21	,	,	PUNCT
aji-34	217	22	they	they	PRON
aji-34	217	23	have	have	VERB
aji-34	217	24	a	a	DET
aji-34	217	25	cytoplasmic	cytoplasmic	ADJ
aji-34	217	26	tail	tail	NOUN
aji-34	217	27	and	and	CCONJ
aji-34	217	28	are	be	AUX
aji-34	217	29	capable	capable	ADJ
aji-34	217	30	of	of	ADP
aji-34	217	31	intracellular	intracellular	ADJ
aji-34	217	32	signaling	signal	VERB
aji-34	217	33	,	,	PUNCT
aji-34	217	34	while	while	SCONJ
aji-34	217	35	type	type	NOUN
aji-34	217	36	ii	ii	NOUN
aji-34	217	37	receptors	receptor	NOUN
aji-34	217	38	are	be	AUX
aji-34	217	39	expressed	express	VERB
aji-34	217	40	primarily	primarily	ADV
aji-34	217	41	on	on	ADP
aji-34	217	42	neutrophils	neutrophil	NOUN
aji-34	217	43	,	,	PUNCT
aji-34	217	44	monocytes	monocyte	NOUN
aji-34	217	45	and	and	CCONJ
aji-34	217	46	b	b	NOUN
aji-34	217	47	cells	cell	NOUN
aji-34	217	48	,	,	PUNCT
aji-34	217	49	they	they	PRON
aji-34	217	50	are	be	AUX
aji-34	217	51	decoy	decoy	NOUN
aji-34	217	52	receptors	receptor	NOUN
aji-34	217	53	which	which	PRON
aji-34	217	54	bind	bind	VERB
aji-34	217	55	circulating	circulate	VERB
aji-34	217	56	il-1	il-1	ADP
aji-34	217	57	without	without	ADP
aji-34	217	58	delivering	deliver	VERB
aji-34	217	59	any	any	DET
aji-34	217	60	intracellular	intracellular	ADJ
aji-34	217	61	signal	signal	NOUN
aji-34	218	1	[	[	X
aji-34	218	2	53	53	NUM
aji-34	218	3	]	]	PUNCT
aji-34	218	4	.	.	PUNCT
aji-34	219	1	soluble	soluble	ADJ
aji-34	219	2	forms	form	NOUN
aji-34	219	3	of	of	ADP
aji-34	219	4	both	both	DET
aji-34	219	5	types	type	NOUN
aji-34	219	6	of	of	ADP
aji-34	219	7	il-1r	il-1r	PROPN
aji-34	219	8	compete	compete	VERB
aji-34	219	9	with	with	ADP
aji-34	219	10	cell	cell	NOUN
aji-34	219	11	surface	surface	NOUN
aji-34	219	12	receptors	receptor	NOUN
aji-34	219	13	thereby	thereby	ADV
aji-34	219	14	decreasing	decrease	VERB
aji-34	219	15	il1	il1	NOUN
aji-34	219	16	mediated	mediate	VERB
aji-34	219	17	activation	activation	NOUN
aji-34	219	18	of	of	ADP
aji-34	219	19	cells	cell	NOUN
aji-34	219	20	[	[	X
aji-34	219	21	54	54	NUM
aji-34	219	22	]	]	PUNCT
aji-34	219	23	.	.	PUNCT
aji-34	220	1	il-1ra	il-1ra	NOUN
aji-34	220	2	,	,	PUNCT
aji-34	220	3	binds	bind	VERB
aji-34	220	4	the	the	DET
aji-34	220	5	type	type	NOUN
aji-34	220	6	i	i	PRON
aji-34	220	7	receptor	receptor	VERB
aji-34	220	8	with	with	ADP
aji-34	220	9	high	high	ADJ
aji-34	220	10	affinity	affinity	NOUN
aji-34	220	11	without	without	ADP
aji-34	220	12	triggering	trigger	VERB
aji-34	220	13	a	a	DET
aji-34	220	14	signal	signal	NOUN
aji-34	220	15	,	,	PUNCT
aji-34	220	16	therefore	therefore	ADV
aji-34	220	17	providing	provide	VERB
aji-34	220	18	another	another	DET
aji-34	220	19	mechanism	mechanism	NOUN
aji-34	220	20	for	for	ADP
aji-34	220	21	inhibiting	inhibit	VERB
aji-34	220	22	the	the	DET
aji-34	220	23	il-1	il-1	ADJ
aji-34	220	24	activity	activity	NOUN
aji-34	220	25	[	[	X
aji-34	220	26	55	55	NUM
aji-34	220	27	]	]	PUNCT
aji-34	220	28	.	.	PUNCT
aji-34	221	1	il1	il1	PROPN
aji-34	221	2	plays	play	VERB
aji-34	221	3	a	a	DET
aji-34	221	4	critical	critical	ADJ
aji-34	221	5	role	role	NOUN
aji-34	221	6	in	in	ADP
aji-34	221	7	joint	joint	ADJ
aji-34	221	8	damage	damage	NOUN
aji-34	221	9	by	by	ADP
aji-34	221	10	facilitating	facilitate	VERB
aji-34	221	11	the	the	DET
aji-34	221	12	degradation	degradation	NOUN
aji-34	221	13	of	of	ADP
aji-34	221	14	cartilage	cartilage	NOUN
aji-34	221	15	which	which	PRON
aji-34	221	16	leads	lead	VERB
aji-34	221	17	to	to	PART
aji-34	221	18	rheumatoid	rheumatoid	VERB
aji-34	221	19	arthritis	arthritis	NOUN
aji-34	221	20	,	,	PUNCT
aji-34	221	21	whereas	whereas	SCONJ
aji-34	221	22	the	the	DET
aji-34	221	23	injection	injection	NOUN
aji-34	221	24	of	of	ADP
aji-34	221	25	antibodies	antibody	NOUN
aji-34	221	26	against	against	ADP
aji-34	221	27	il-1	il-1	NOUN
aji-34	221	28	suppresses	suppress	VERB
aji-34	221	29	collagen	collagen	NOUN
aji-34	221	30	-	-	PUNCT
aji-34	221	31	induced	induce	VERB
aji-34	221	32	arthritis	arthritis	NOUN
aji-34	221	33	in	in	ADP
aji-34	221	34	mice	mouse	NOUN
aji-34	221	35	and	and	CCONJ
aji-34	221	36	decreases	decrease	VERB
aji-34	221	37	the	the	DET
aji-34	221	38	damage	damage	NOUN
aji-34	221	39	to	to	ADP
aji-34	221	40	the	the	DET
aji-34	221	41	cartilage	cartilage	NOUN
aji-34	221	42	[	[	X
aji-34	221	43	56	56	NUM
aji-34	221	44	]	]	PUNCT
aji-34	221	45	.	.	PUNCT
aji-34	222	1	anti	anti	ADJ
aji-34	222	2	-	-	ADJ
aji-34	222	3	interleukin	interleukin	ADJ
aji-34	222	4	6	6	NUM
aji-34	222	5	receptor	receptor	NOUN
aji-34	222	6	:	:	PUNCT
aji-34	222	7	interleukin-6	interleukin-6	NUM
aji-34	222	8	(	(	PUNCT
aji-34	222	9	il-6	il-6	NOUN
aji-34	222	10	)	)	PUNCT
aji-34	222	11	is	be	AUX
aji-34	222	12	a	a	DET
aji-34	222	13	major	major	ADJ
aji-34	222	14	pro	pro	ADJ
aji-34	222	15	-	-	ADJ
aji-34	222	16	inflammatory	inflammatory	ADJ
aji-34	222	17	cytokine	cytokine	NOUN
aji-34	222	18	with	with	ADP
aji-34	222	19	pleiotropic	pleiotropic	ADJ
aji-34	222	20	functions	function	NOUN
aji-34	222	21	,	,	PUNCT
aji-34	222	22	il-6	il-6	PRON
aji-34	222	23	plays	play	VERB
aji-34	222	24	a	a	DET
aji-34	222	25	key	key	ADJ
aji-34	222	26	role	role	NOUN
aji-34	222	27	in	in	ADP
aji-34	222	28	immune	immune	ADJ
aji-34	222	29	activation	activation	NOUN
aji-34	222	30	and	and	CCONJ
aji-34	222	31	inflammation	inflammation	NOUN
aji-34	222	32	in	in	ADP
aji-34	222	33	ra	ra	PROPN
aji-34	222	34	,	,	PUNCT
aji-34	222	35	thus	thus	ADV
aji-34	222	36	,	,	PUNCT
aji-34	222	37	inhibition	inhibition	NOUN
aji-34	222	38	of	of	ADP
aji-34	222	39	il-6	il-6	NOUN
aji-34	222	40	is	be	AUX
aji-34	222	41	a	a	DET
aji-34	222	42	good	good	ADJ
aji-34	222	43	strategy	strategy	NOUN
aji-34	222	44	in	in	ADP
aji-34	222	45	controlling	control	VERB
aji-34	222	46	ra	ra	PROPN
aji-34	223	1	[	[	X
aji-34	223	2	57	57	NUM
aji-34	223	3	]	]	PUNCT
aji-34	223	4	.	.	PUNCT
aji-34	224	1	il-6	il-6	NOUN
aji-34	224	2	has	have	VERB
aji-34	224	3	diverse	diverse	ADJ
aji-34	224	4	and	and	CCONJ
aji-34	224	5	protein	protein	NOUN
aji-34	224	6	effects	effect	NOUN
aji-34	224	7	on	on	ADP
aji-34	224	8	many	many	ADJ
aji-34	224	9	cell	cell	NOUN
aji-34	224	10	types	type	NOUN
aji-34	224	11	,	,	PUNCT
aji-34	224	12	involved	involve	VERB
aji-34	224	13	in	in	ADP
aji-34	224	14	both	both	CCONJ
aji-34	224	15	homeostatic	homeostatic	ADJ
aji-34	224	16	and	and	CCONJ
aji-34	224	17	inflammatory	inflammatory	ADJ
aji-34	224	18	pathways	pathway	NOUN
aji-34	224	19	,	,	PUNCT
aji-34	224	20	however	however	ADV
aji-34	224	21	anti	anti	ADJ
aji-34	224	22	-	-	ADJ
aji-34	224	23	il-6	il-6	ADJ
aji-34	224	24	receptor	receptor	NOUN
aji-34	224	25	agent	agent	NOUN
aji-34	224	26	tocilizumab	tocilizumab	NOUN
aji-34	224	27	(	(	PUNCT
aji-34	224	28	tcz	tcz	PROPN
aji-34	224	29	)	)	PUNCT
aji-34	224	30	has	have	AUX
aji-34	224	31	become	become	VERB
aji-34	224	32	a	a	DET
aji-34	224	33	major	major	ADJ
aji-34	224	34	resource	resource	NOUN
aji-34	224	35	for	for	ADP
aji-34	224	36	the	the	DET
aji-34	224	37	treatment	treatment	NOUN
aji-34	224	38	of	of	ADP
aji-34	224	39	ra	ra	PROPN
aji-34	225	1	[	[	X
aji-34	225	2	58	58	NUM
aji-34	225	3	]	]	PUNCT
aji-34	225	4	.	.	PUNCT
aji-34	226	1	in	in	ADP
aji-34	226	2	patients	patient	NOUN
aji-34	226	3	with	with	ADP
aji-34	226	4	ra	ra	PROPN
aji-34	226	5	,	,	PUNCT
aji-34	226	6	tcz	tcz	PROPN
aji-34	226	7	has	have	VERB
aji-34	226	8	a	a	DET
aji-34	226	9	dramatic	dramatic	ADJ
aji-34	226	10	effect	effect	NOUN
aji-34	226	11	on	on	ADP
aji-34	226	12	b	b	PROPN
aji-34	226	13	lineage	lineage	NOUN
aji-34	226	14	cells	cell	NOUN
aji-34	226	15	,	,	PUNCT
aji-34	226	16	with	with	ADP
aji-34	226	17	decreases	decrease	NOUN
aji-34	226	18	in	in	ADP
aji-34	226	19	levels	level	NOUN
aji-34	226	20	of	of	ADP
aji-34	226	21	circulating	circulate	VERB
aji-34	226	22	switched	switch	VERB
aji-34	226	23	and	and	CCONJ
aji-34	226	24	unswitched	unswitched	ADJ
aji-34	226	25	memory	memory	NOUN
aji-34	226	26	b	b	PROPN
aji-34	226	27	cells	cell	NOUN
aji-34	226	28	and	and	CCONJ
aji-34	226	29	with	with	ADP
aji-34	226	30	overall	overall	ADJ
aji-34	226	31	decreases	decrease	NOUN
aji-34	226	32	in	in	ADP
aji-34	226	33	measured	measured	ADJ
aji-34	226	34	levels	level	NOUN
aji-34	226	35	of	of	ADP
aji-34	226	36	antibody	antibody	NOUN
aji-34	226	37	gene	gene	NOUN
aji-34	226	38	hypermutation	hypermutation	NOUN
aji-34	226	39	in	in	ADP
aji-34	226	40	blood	blood	NOUN
aji-34	226	41	b	b	PROPN
aji-34	226	42	cells	cell	NOUN
aji-34	226	43	[	[	X
aji-34	226	44	59	59	NUM
aji-34	226	45	]	]	PUNCT
aji-34	226	46	.	.	PUNCT
aji-34	227	1	a	a	DET
aji-34	227	2	humanized	humanize	VERB
aji-34	227	3	il-6r	il-6r	ADJ
aji-34	227	4	antibody	antibody	NOUN
aji-34	227	5	,	,	PUNCT
aji-34	227	6	tocilizumab	tocilizumab	NOUN
aji-34	227	7	(	(	PUNCT
aji-34	227	8	tcz	tcz	PROPN
aji-34	227	9	)	)	PUNCT
aji-34	227	10	,	,	PUNCT
aji-34	227	11	was	be	AUX
aji-34	227	12	developed	develop	VERB
aji-34	227	13	by	by	ADP
aji-34	227	14	a	a	DET
aji-34	227	15	research	research	NOUN
aji-34	227	16	team	team	NOUN
aji-34	227	17	from	from	ADP
aji-34	227	18	chugai	chugai	PROPN
aji-34	227	19	pharmaceutical	pharmaceutical	NOUN
aji-34	227	20	company	company	NOUN
aji-34	227	21	and	and	CCONJ
aji-34	227	22	osaka	osaka	PROPN
aji-34	227	23	university	university	PROPN
aji-34	227	24	in	in	ADP
aji-34	227	25	japan	japan	PROPN
aji-34	228	1	[	[	X
aji-34	228	2	59	59	NUM
aji-34	228	3	]	]	PUNCT
aji-34	228	4	.	.	PUNCT
aji-34	229	1	after	after	ADP
aji-34	229	2	several	several	ADJ
aji-34	229	3	randomized	randomized	ADJ
aji-34	229	4	clinical	clinical	ADJ
aji-34	229	5	trials	trial	NOUN
aji-34	229	6	(	(	PUNCT
aji-34	229	7	rcts	rct	NOUN
aji-34	229	8	)	)	PUNCT
aji-34	229	9	,	,	PUNCT
aji-34	229	10	an	an	DET
aji-34	229	11	intravenous	intravenous	ADJ
aji-34	229	12	formulation	formulation	NOUN
aji-34	229	13	of	of	ADP
aji-34	229	14	tcz	tcz	PROPN
aji-34	229	15	(	(	PUNCT
aji-34	229	16	tcz	tcz	PROPN
aji-34	229	17	-	-	PUNCT
aji-34	229	18	iv	iv	NOUN
aji-34	229	19	)	)	PUNCT
aji-34	229	20	was	be	AUX
aji-34	229	21	approved	approve	VERB
aji-34	229	22	for	for	ADP
aji-34	229	23	ra	ra	PROPN
aji-34	229	24	treatment	treatment	NOUN
aji-34	229	25	in	in	ADP
aji-34	229	26	japan	japan	PROPN
aji-34	229	27	in	in	ADP
aji-34	229	28	2008	2008	NUM
aji-34	229	29	,	,	PUNCT
aji-34	229	30	in	in	ADP
aji-34	229	31	europe	europe	PROPN
aji-34	229	32	in	in	ADP
aji-34	229	33	2009	2009	NUM
aji-34	229	34	,	,	PUNCT
aji-34	229	35	and	and	CCONJ
aji-34	229	36	in	in	ADP
aji-34	229	37	the	the	DET
aji-34	229	38	usa	usa	PROPN
aji-34	229	39	in	in	ADP
aji-34	229	40	2010	2010	NUM
aji-34	230	1	[	[	X
aji-34	230	2	58	58	NUM
aji-34	230	3	]	]	PUNCT
aji-34	230	4	.	.	PUNCT
aji-34	231	1	recently	recently	ADV
aji-34	231	2	,	,	PUNCT
aji-34	231	3	a	a	DET
aji-34	231	4	subcutaneous	subcutaneous	ADJ
aji-34	231	5	formulation	formulation	NOUN
aji-34	231	6	of	of	ADP
aji-34	231	7	tcz	tcz	PROPN
aji-34	231	8	(	(	PUNCT
aji-34	231	9	tcz	tcz	PROPN
aji-34	231	10	-	-	PROPN
aji-34	231	11	sc	sc	PROPN
aji-34	231	12	)	)	PUNCT
aji-34	231	13	was	be	AUX
aji-34	231	14	developed	develop	VERB
aji-34	231	15	in	in	ADP
aji-34	231	16	consideration	consideration	NOUN
aji-34	231	17	of	of	ADP
aji-34	231	18	patients	patient	NOUN
aji-34	231	19	’	'	PUNCT
aji-34	231	20	preferences	preference	NOUN
aji-34	231	21	after	after	ADP
aji-34	231	22	a	a	DET
aji-34	231	23	non	non	ADJ
aji-34	231	24	-	-	ADJ
aji-34	231	25	inferiority	inferiority	ADJ
aji-34	231	26	trial	trial	NOUN
aji-34	231	27	of	of	ADP
aji-34	231	28	tczsc	tczsc	NOUN
aji-34	231	29	and	and	CCONJ
aji-34	231	30	tcz	tcz	PROPN
aji-34	231	31	-	-	PUNCT
aji-34	231	32	iv	iv	NOUN
aji-34	231	33	,	,	PUNCT
aji-34	231	34	tcz	tcz	PROPN
aji-34	231	35	-	-	PUNCT
aji-34	231	36	sc	sc	PROPN
aji-34	231	37	was	be	AUX
aji-34	231	38	approved	approve	VERB
aji-34	231	39	in	in	ADP
aji-34	231	40	japan	japan	PROPN
aji-34	231	41	and	and	CCONJ
aji-34	231	42	the	the	DET
aji-34	231	43	usa	usa	PROPN
aji-34	231	44	in	in	ADP
aji-34	231	45	2013	2013	NUM
aji-34	231	46	and	and	CCONJ
aji-34	231	47	europe	europe	PROPN
aji-34	231	48	in	in	ADP
aji-34	231	49	2014	2014	NUM
aji-34	232	1	[	[	X
aji-34	232	2	60	60	NUM
aji-34	232	3	]	]	PUNCT
aji-34	232	4	.	.	PUNCT
aji-34	233	1	tcz	tcz	PROPN
aji-34	233	2	displays	display	VERB
aji-34	233	3	a	a	DET
aji-34	233	4	good	good	ADJ
aji-34	233	5	efficacy	efficacy	NOUN
aji-34	233	6	in	in	ADP
aji-34	233	7	patients	patient	NOUN
aji-34	233	8	with	with	ADP
aji-34	233	9	ra	ra	PROPN
aji-34	233	10	,	,	PUNCT
aji-34	233	11	including	include	VERB
aji-34	233	12	disease	disease	NOUN
aji-34	233	13	-	-	PUNCT
aji-34	233	14	modifying	modify	VERB
aji-34	233	15	antirheumatic	antirheumatic	ADJ
aji-34	233	16	drug	drug	NOUN
aji-34	233	17	(	(	PUNCT
aji-34	233	18	dmard	dmard	ADJ
aji-34	233	19	)	)	PUNCT
aji-34	233	20	naïve	naïve	ADJ
aji-34	233	21	patients	patient	NOUN
aji-34	233	22	and	and	CCONJ
aji-34	233	23	patients	patient	NOUN
aji-34	233	24	with	with	ADP
aji-34	233	25	an	an	DET
aji-34	233	26	inadequate	inadequate	ADJ
aji-34	233	27	response	response	NOUN
aji-34	233	28	to	to	ADP
aji-34	233	29	conventional	conventional	ADJ
aji-34	233	30	synthetic	synthetic	ADJ
aji-34	233	31	dmards	dmard	NOUN
aji-34	233	32	(	(	PUNCT
aji-34	233	33	csdmards	csdmard	NOUN
aji-34	233	34	)	)	PUNCT
aji-34	233	35	,	,	PUNCT
aji-34	233	36	methotrexate	methotrexate	NOUN
aji-34	233	37	(	(	PUNCT
aji-34	233	38	mtx	mtx	NOUN
aji-34	233	39	)	)	PUNCT
aji-34	233	40	,	,	PUNCT
aji-34	233	41	or	or	CCONJ
aji-34	233	42	tnf	tnf	PROPN
aji-34	233	43	inhibitors	inhibitor	NOUN
aji-34	233	44	(	(	PUNCT
aji-34	233	45	tnfi	tnfi	INTJ
aji-34	233	46	)	)	PUNCT
aji-34	234	1	[	[	X
aji-34	234	2	60	60	NUM
aji-34	234	3	]	]	PUNCT
aji-34	234	4	.	.	PUNCT
aji-34	235	1	table	table	NOUN
aji-34	235	2	2	2	NUM
aji-34	235	3	.	.	PUNCT
aji-34	235	4	showing	show	VERB
aji-34	235	5	tnf	tnf	PROPN
aji-34	235	6	-	-	PUNCT
aji-34	235	7	α	α	PROPN
aji-34	235	8	blockers	blocker	NOUN
aji-34	235	9	as	as	ADP
aji-34	235	10	the	the	DET
aji-34	235	11	first	first	ADJ
aji-34	235	12	therapeutic	therapeutic	ADJ
aji-34	235	13	agents	agent	NOUN
aji-34	235	14	approved	approve	VERB
aji-34	235	15	for	for	ADP
aji-34	235	16	the	the	DET
aji-34	235	17	treatment	treatment	NOUN
aji-34	235	18	of	of	ADP
aji-34	235	19	rheumatoid	rheumatoid	NOUN
aji-34	235	20	arthritis	arthritis	NOUN
aji-34	236	1	;	;	PUNCT
aji-34	236	2	tnf	tnf	PROPN
aji-34	236	3	-	-	PUNCT
aji-34	236	4	α	α	PROPN
aji-34	236	5	blockade	blockade	NOUN
aji-34	236	6	has	have	AUX
aji-34	236	7	become	become	VERB
aji-34	236	8	a	a	DET
aji-34	236	9	central	central	ADJ
aji-34	236	10	strategy	strategy	NOUN
aji-34	236	11	of	of	ADP
aji-34	236	12	targeted	target	VERB
aji-34	236	13	antiinflammatory	antiinflammatory	NOUN
aji-34	236	14	therapy	therapy	NOUN
aji-34	236	15	in	in	ADP
aji-34	236	16	the	the	DET
aji-34	236	17	disease	disease	NOUN
aji-34	236	18	agent	agent	NOUN
aji-34	236	19	class	class	NOUN
aji-34	236	20	target	target	NOUN
aji-34	236	21	structure	structure	NOUN
aji-34	236	22	ref	ref	NOUN
aji-34	236	23	.	.	PUNCT
aji-34	237	1	adalimumab	adalimumab	PROPN
aji-34	237	2	cytokine	cytokine	PROPN
aji-34	237	3	inhibitor	inhibitor	NOUN
aji-34	237	4	tnf	tnf	PROPN
aji-34	237	5	-	-	PUNCT
aji-34	237	6	α	α	PROPN
aji-34	237	7	human	human	ADJ
aji-34	237	8	monoclonal	monoclonal	NOUN
aji-34	237	9	antibody	antibody	NOUN
aji-34	237	10	[	[	X
aji-34	237	11	50	50	NUM
aji-34	237	12	]	]	PUNCT
aji-34	237	13	certolizumab	certolizumab	NOUN
aji-34	237	14	cytokine	cytokine	PROPN
aji-34	237	15	inhibitor	inhibitor	NOUN
aji-34	237	16	tnf	tnf	PROPN
aji-34	237	17	-	-	PUNCT
aji-34	237	18	α	α	PROPN
aji-34	237	19	egylated	egylate	VERB
aji-34	237	20	humani	humani	PROPN
aji-34	237	21	ed	ed	PROPN
aji-34	237	22	fab	fab	PROPN
aji-34	237	23	fragment	fragment	NOUN
aji-34	237	24	of	of	ADP
aji-34	237	25	an	an	DET
aji-34	237	26	anti	anti	ADJ
aji-34	237	27	–	–	PUNCT
aji-34	237	28	tnf	tnf	ADJ
aji-34	237	29	-	-	PUNCT
aji-34	237	30	α	α	NOUN
aji-34	237	31	monoclonal	monoclonal	NOUN
aji-34	237	32	antibody	antibody	NOUN
aji-34	238	1	[	[	X
aji-34	238	2	50	50	NUM
aji-34	238	3	]	]	PUNCT
aji-34	238	4	etanercept	etanercept	VERB
aji-34	238	5	cytokine	cytokine	ADJ
aji-34	238	6	inhibitor	inhibitor	NOUN
aji-34	238	7	tnf	tnf	PROPN
aji-34	238	8	-	-	PUNCT
aji-34	238	9	α	α	PROPN
aji-34	238	10	tnf	tnf	PROPN
aji-34	238	11	-	-	PUNCT
aji-34	238	12	α	α	NOUN
aji-34	238	13	receptor	receptor	NOUN
aji-34	238	14	–	–	PUNCT
aji-34	238	15	fc	fc	NOUN
aji-34	238	16	fusion	fusion	NOUN
aji-34	238	17	[	[	X
aji-34	238	18	50	50	NUM
aji-34	238	19	]	]	PUNCT
aji-34	238	20	golimumab	golimumab	NOUN
aji-34	238	21	cytokine	cytokine	ADJ
aji-34	238	22	inhibitor	inhibitor	NOUN
aji-34	238	23	tnf	tnf	PROPN
aji-34	238	24	-	-	PUNCT
aji-34	238	25	α	α	PROPN
aji-34	238	26	human	human	ADJ
aji-34	238	27	monoclonal	monoclonal	NOUN
aji-34	238	28	antibody	antibody	NOUN
aji-34	238	29	[	[	X
aji-34	238	30	50	50	NUM
aji-34	238	31	]	]	PUNCT
aji-34	238	32	infliximab	infliximab	NOUN
aji-34	238	33	cytokine	cytokine	PROPN
aji-34	238	34	inhibitor	inhibitor	NOUN
aji-34	238	35	tnf	tnf	PROPN
aji-34	238	36	-	-	PUNCT
aji-34	238	37	α	α	PROPN
aji-34	238	38	chimeric	chimeric	ADJ
aji-34	238	39	monoclonal	monoclonal	NOUN
aji-34	238	40	antibody	antibody	NOUN
aji-34	238	41	[	[	X
aji-34	238	42	50	50	NUM
aji-34	238	43	]	]	PUNCT
aji-34	238	44	shehu	shehu	NOUN
aji-34	238	45	et	et	PROPN
aji-34	238	46	al	al	PROPN
aji-34	238	47	.	.	PROPN
aji-34	238	48	;	;	PUNCT
aji-34	238	49	aji	aji	PROPN
aji-34	238	50	,	,	PUNCT
aji-34	238	51	3(1	3(1	NUM
aji-34	238	52	):	):	PUNCT
aji-34	238	53	259	259	NUM
aji-34	238	54	-	-	SYM
aji-34	238	55	268	268	NUM
aji-34	238	56	,	,	PUNCT
aji-34	238	57	2020	2020	NUM
aji-34	238	58	;	;	PUNCT
aji-34	238	59	article	article	NOUN
aji-34	238	60	no.aji.57314	no.aji.57314	NOUN
aji-34	238	61	265	265	NUM
aji-34	238	62	table	table	NOUN
aji-34	238	63	3	3	NUM
aji-34	238	64	.	.	PUNCT
aji-34	239	1	this	this	DET
aji-34	239	2	therapeutic	therapeutic	ADJ
aji-34	239	3	agent	agent	NOUN
aji-34	239	4	is	be	AUX
aji-34	239	5	considered	consider	VERB
aji-34	239	6	one	one	NUM
aji-34	239	7	of	of	ADP
aji-34	239	8	the	the	DET
aji-34	239	9	cytokine	cytokine	NOUN
aji-34	239	10	blockades	blockade	VERB
aji-34	239	11	in	in	ADP
aji-34	239	12	rheumatoid	rheumatoid	NOUN
aji-34	239	13	arthritis	arthritis	NOUN
aji-34	239	14	;	;	PUNCT
aji-34	239	15	it	it	PRON
aji-34	239	16	has	have	VERB
aji-34	239	17	profound	profound	ADJ
aji-34	239	18	effects	effect	NOUN
aji-34	239	19	on	on	ADP
aji-34	239	20	systemic	systemic	ADJ
aji-34	239	21	features	feature	NOUN
aji-34	239	22	,	,	PUNCT
aji-34	239	23	acute	acute	ADJ
aji-34	239	24	phase	phase	NOUN
aji-34	239	25	response	response	NOUN
aji-34	239	26	and	and	CCONJ
aji-34	239	27	synovitis	synovitis	ADJ
aji-34	239	28	agent	agent	NOUN
aji-34	239	29	class	class	NOUN
aji-34	239	30	target	target	NOUN
aji-34	239	31	structure	structure	NOUN
aji-34	239	32	ref	ref	NOUN
aji-34	239	33	anakinra	anakinra	NOUN
aji-34	239	34	cytokine	cytokine	ADJ
aji-34	239	35	inhibitor	inhibitor	NOUN
aji-34	239	36	interleukin-1	interleukin-1	NOUN
aji-34	239	37	interleukin-1	interleukin-1	NOUN
aji-34	239	38	receptor	receptor	NOUN
aji-34	239	39	antagonist	antagonist	NOUN
aji-34	239	40	[	[	X
aji-34	239	41	57	57	NUM
aji-34	239	42	]	]	SYM
aji-34	239	43	table	table	NOUN
aji-34	239	44	4	4	NUM
aji-34	239	45	.	.	PUNCT
aji-34	240	1	this	this	DET
aji-34	240	2	therapeutic	therapeutic	ADJ
aji-34	240	3	agent	agent	NOUN
aji-34	240	4	is	be	AUX
aji-34	240	5	considered	consider	VERB
aji-34	240	6	to	to	PART
aji-34	240	7	be	be	AUX
aji-34	240	8	one	one	NUM
aji-34	240	9	of	of	ADP
aji-34	240	10	the	the	DET
aji-34	240	11	cytokine	cytokine	NOUN
aji-34	240	12	blockades	blockade	VERB
aji-34	240	13	in	in	ADP
aji-34	240	14	rheumatoid	rheumatoid	NOUN
aji-34	240	15	arthritis	arthritis	NOUN
aji-34	240	16	;	;	PUNCT
aji-34	240	17	it	it	PRON
aji-34	240	18	has	have	VERB
aji-34	240	19	profound	profound	ADJ
aji-34	240	20	effects	effect	NOUN
aji-34	240	21	on	on	ADP
aji-34	240	22	systemic	systemic	ADJ
aji-34	240	23	features	feature	NOUN
aji-34	240	24	,	,	PUNCT
aji-34	240	25	acute	acute	ADJ
aji-34	240	26	phase	phase	NOUN
aji-34	240	27	response	response	NOUN
aji-34	240	28	and	and	CCONJ
aji-34	240	29	synovitis	synovitis	PROPN
aji-34	240	30	.	.	PUNCT
aji-34	241	1	agent	agent	NOUN
aji-34	241	2	class	class	NOUN
aji-34	241	3	target	target	NOUN
aji-34	241	4	structure	structure	NOUN
aji-34	241	5	ref	ref	NOUN
aji-34	241	6	tocilizumab	tocilizumab	NOUN
aji-34	241	7	cytokine	cytokine	ADJ
aji-34	241	8	inhibitor	inhibitor	NOUN
aji-34	241	9	interleukin-6	interleukin-6	PRON
aji-34	241	10	receptor	receptor	NOUN
aji-34	241	11	human	human	ADJ
aji-34	241	12	monoclonal	monoclonal	NOUN
aji-34	241	13	antibodies	antibodie	VERB
aji-34	242	1	[	[	X
aji-34	242	2	63	63	NUM
aji-34	242	3	]	]	PUNCT
aji-34	242	4	the	the	DET
aji-34	242	5	overall	overall	ADJ
aji-34	242	6	efficacy	efficacy	NOUN
aji-34	242	7	including	include	VERB
aji-34	242	8	clinical	clinical	ADJ
aji-34	242	9	responses	response	NOUN
aji-34	242	10	and	and	CCONJ
aji-34	242	11	the	the	DET
aji-34	242	12	radiographic	radiographic	ADJ
aji-34	242	13	damage	damage	NOUN
aji-34	242	14	progression	progression	NOUN
aji-34	242	15	of	of	ADP
aji-34	242	16	tcz	tcz	PROPN
aji-34	242	17	was	be	AUX
aji-34	242	18	comparable	comparable	ADJ
aji-34	242	19	to	to	ADP
aji-34	242	20	that	that	PRON
aji-34	242	21	of	of	ADP
aji-34	242	22	other	other	ADJ
aji-34	242	23	biological	biological	ADJ
aji-34	242	24	dmards	dmard	NOUN
aji-34	242	25	such	such	ADJ
aji-34	242	26	as	as	ADP
aji-34	242	27	tnfi	tnfi	NOUN
aji-34	242	28	[	[	X
aji-34	242	29	61	61	NUM
aji-34	242	30	]	]	X
aji-34	242	31	.	.	PUNCT
aji-34	243	1	il-6	il-6	NOUN
aji-34	243	2	was	be	AUX
aji-34	243	3	found	find	VERB
aji-34	243	4	to	to	PART
aji-34	243	5	affects	affect	VERB
aji-34	243	6	psychosomatic	psychosomatic	ADJ
aji-34	243	7	functioning	functioning	NOUN
aji-34	243	8	,	,	PUNCT
aji-34	243	9	sleep	sleep	NOUN
aji-34	243	10	-	-	PUNCT
aji-34	243	11	related	relate	VERB
aji-34	243	12	symptoms	symptom	NOUN
aji-34	243	13	,	,	PUNCT
aji-34	243	14	and	and	CCONJ
aji-34	243	15	fatigue	fatigue	NOUN
aji-34	243	16	,	,	PUNCT
aji-34	243	17	while	while	SCONJ
aji-34	243	18	on	on	ADP
aji-34	243	19	the	the	DET
aji-34	243	20	other	other	ADJ
aji-34	243	21	hand	hand	NOUN
aji-34	243	22	,	,	PUNCT
aji-34	243	23	tcz	tcz	PROPN
aji-34	243	24	improves	improve	VERB
aji-34	243	25	sleep	sleep	NOUN
aji-34	243	26	quality	quality	NOUN
aji-34	243	27	and	and	CCONJ
aji-34	243	28	fatigue	fatigue	NOUN
aji-34	243	29	[	[	X
aji-34	243	30	62	62	NUM
aji-34	243	31	]	]	PUNCT
aji-34	243	32	.	.	PUNCT
aji-34	244	1	4	4	X
aji-34	244	2	.	.	X
aji-34	244	3	conclusion	conclusion	NOUN
aji-34	244	4	this	this	DET
aji-34	244	5	review	review	NOUN
aji-34	244	6	has	have	AUX
aji-34	244	7	summarized	summarize	VERB
aji-34	244	8	the	the	DET
aji-34	244	9	critical	critical	ADJ
aji-34	244	10	role	role	NOUN
aji-34	244	11	played	play	VERB
aji-34	244	12	by	by	ADP
aji-34	244	13	the	the	DET
aji-34	244	14	cytokines	cytokine	NOUN
aji-34	244	15	in	in	ADP
aji-34	244	16	the	the	DET
aji-34	244	17	pathogenesis	pathogenesis	NOUN
aji-34	244	18	of	of	ADP
aji-34	244	19	ra	ra	PROPN
aji-34	244	20	.	.	PUNCT
aji-34	245	1	persistent	persistent	ADJ
aji-34	245	2	recruitment	recruitment	NOUN
aji-34	245	3	and	and	CCONJ
aji-34	245	4	activation	activation	NOUN
aji-34	245	5	of	of	ADP
aji-34	245	6	macrophages	macrophage	NOUN
aji-34	245	7	and	and	CCONJ
aji-34	245	8	monocytes	monocyte	NOUN
aji-34	245	9	occur	occur	VERB
aji-34	245	10	with	with	ADP
aji-34	245	11	the	the	DET
aji-34	245	12	recruitment	recruitment	NOUN
aji-34	245	13	of	of	ADP
aji-34	245	14	pro	pro	ADJ
aji-34	245	15	-	-	ADJ
aji-34	245	16	inflammatory	inflammatory	ADJ
aji-34	245	17	cytokines	cytokine	NOUN
aji-34	245	18	,	,	PUNCT
aji-34	245	19	specifically	specifically	ADV
aji-34	245	20	tnf	tnf	PROPN
aji-34	245	21	-	-	PUNCT
aji-34	245	22	α	α	PROPN
aji-34	245	23	and	and	CCONJ
aji-34	245	24	il-1	il-1	ADP
aji-34	245	25	and	and	CCONJ
aji-34	245	26	il-6	il-6	NOUN
aji-34	245	27	into	into	ADP
aji-34	245	28	the	the	DET
aji-34	245	29	synovial	synovial	ADJ
aji-34	245	30	cavity	cavity	NOUN
aji-34	245	31	which	which	PRON
aji-34	245	32	leads	lead	VERB
aji-34	245	33	to	to	ADP
aji-34	245	34	tissue	tissue	NOUN
aji-34	245	35	destruction	destruction	NOUN
aji-34	245	36	by	by	ADP
aji-34	245	37	activation	activation	NOUN
aji-34	245	38	of	of	ADP
aji-34	245	39	chondrocytes	chondrocyte	NOUN
aji-34	245	40	and	and	CCONJ
aji-34	245	41	fibroblasts	fibroblast	NOUN
aji-34	245	42	thereby	thereby	ADV
aji-34	245	43	releasing	release	VERB
aji-34	245	44	collagenases	collagenase	NOUN
aji-34	245	45	and	and	CCONJ
aji-34	245	46	metalloproteinase	metalloproteinase	NOUN
aji-34	245	47	with	with	ADP
aji-34	245	48	resultant	resultant	NOUN
aji-34	245	49	cartilage	cartilage	NOUN
aji-34	245	50	loss	loss	NOUN
aji-34	245	51	and	and	CCONJ
aji-34	245	52	bone	bone	NOUN
aji-34	245	53	erosion	erosion	NOUN
aji-34	245	54	.	.	PUNCT
aji-34	246	1	however	however	ADV
aji-34	246	2	,	,	PUNCT
aji-34	246	3	due	due	ADP
aji-34	246	4	to	to	ADP
aji-34	246	5	the	the	DET
aji-34	246	6	increase	increase	NOUN
aji-34	246	7	morbidity	morbidity	NOUN
aji-34	246	8	and	and	CCONJ
aji-34	246	9	premature	premature	ADJ
aji-34	246	10	mortality	mortality	NOUN
aji-34	246	11	of	of	ADP
aji-34	246	12	ra	ra	PROPN
aji-34	246	13	in	in	ADP
aji-34	246	14	the	the	DET
aji-34	246	15	world	world	NOUN
aji-34	246	16	population	population	NOUN
aji-34	246	17	,	,	PUNCT
aji-34	246	18	many	many	ADJ
aji-34	246	19	therapeutic	therapeutic	ADJ
aji-34	246	20	strategies	strategy	NOUN
aji-34	246	21	are	be	AUX
aji-34	246	22	adopted	adopt	VERB
aji-34	246	23	to	to	PART
aji-34	246	24	overcome	overcome	VERB
aji-34	246	25	the	the	DET
aji-34	246	26	disease	disease	NOUN
aji-34	246	27	.	.	PUNCT
aji-34	247	1	the	the	DET
aji-34	247	2	novel	novel	ADJ
aji-34	247	3	therapeutic	therapeutic	ADJ
aji-34	247	4	approaches	approach	NOUN
aji-34	247	5	to	to	ADP
aji-34	247	6	ra	ra	PROPN
aji-34	247	7	that	that	PRON
aji-34	247	8	are	be	AUX
aji-34	247	9	aimed	aim	VERB
aji-34	247	10	at	at	ADP
aji-34	247	11	restoring	restore	VERB
aji-34	247	12	this	this	DET
aji-34	247	13	cytokines	cytokine	NOUN
aji-34	247	14	imbalance	imbalance	NOUN
aji-34	247	15	include	include	VERB
aji-34	247	16	the	the	DET
aji-34	247	17	use	use	NOUN
aji-34	247	18	of	of	ADP
aji-34	247	19	monoclonal	monoclonal	NOUN
aji-34	247	20	antibodies	antibody	NOUN
aji-34	247	21	to	to	ADP
aji-34	247	22	tnf	tnf	PROPN
aji-34	247	23	-	-	PUNCT
aji-34	247	24	α	α	PROPN
aji-34	247	25	as	as	SCONJ
aji-34	247	26	mentioned	mention	VERB
aji-34	247	27	in	in	ADP
aji-34	247	28	(	(	PUNCT
aji-34	247	29	table	table	NOUN
aji-34	247	30	2	2	NUM
aji-34	247	31	)	)	PUNCT
aji-34	247	32	which	which	PRON
aji-34	247	33	mainly	mainly	ADV
aji-34	247	34	inhibit	inhibit	VERB
aji-34	247	35	the	the	DET
aji-34	247	36	proinflammatory	proinflammatory	ADJ
aji-34	247	37	cytokine	cytokine	NOUN
aji-34	247	38	activity	activity	NOUN
aji-34	247	39	,	,	PUNCT
aji-34	247	40	il-1rantagonist	il-1rantagonist	VERB
aji-34	247	41	such	such	ADJ
aji-34	247	42	as	as	ADP
aji-34	247	43	anakinra	anakinra	NOUN
aji-34	247	44	which	which	PRON
aji-34	247	45	suppresses	suppress	VERB
aji-34	247	46	collagen	collagen	NOUN
aji-34	247	47	-	-	PUNCT
aji-34	247	48	induced	induce	VERB
aji-34	247	49	arthritis	arthritis	NOUN
aji-34	247	50	thereby	thereby	ADV
aji-34	247	51	decreasing	decrease	VERB
aji-34	247	52	the	the	DET
aji-34	247	53	damage	damage	NOUN
aji-34	247	54	to	to	ADP
aji-34	247	55	cartilage	cartilage	NOUN
aji-34	247	56	and	and	CCONJ
aji-34	247	57	the	the	DET
aji-34	247	58	use	use	NOUN
aji-34	247	59	of	of	ADP
aji-34	247	60	tocilizumab	tocilizumab	NOUN
aji-34	247	61	which	which	PRON
aji-34	247	62	displays	display	VERB
aji-34	247	63	a	a	DET
aji-34	247	64	good	good	ADJ
aji-34	247	65	efficacy	efficacy	NOUN
aji-34	247	66	in	in	ADP
aji-34	247	67	patients	patient	NOUN
aji-34	247	68	with	with	ADP
aji-34	247	69	ra	ra	PROPN
aji-34	247	70	,	,	PUNCT
aji-34	247	71	including	include	VERB
aji-34	247	72	disease	disease	NOUN
aji-34	247	73	-	-	PUNCT
aji-34	247	74	modifying	modify	VERB
aji-34	247	75	anti	anti	ADJ
aji-34	247	76	-	-	ADJ
aji-34	247	77	rheumatic	rheumatic	ADJ
aji-34	247	78	drug	drug	NOUN
aji-34	247	79	naïve	naïve	ADJ
aji-34	247	80	patients	patient	NOUN
aji-34	247	81	and	and	CCONJ
aji-34	247	82	patients	patient	NOUN
aji-34	247	83	with	with	ADP
aji-34	247	84	an	an	DET
aji-34	247	85	inadequate	inadequate	ADJ
aji-34	247	86	response	response	NOUN
aji-34	247	87	to	to	ADP
aji-34	247	88	conventional	conventional	ADJ
aji-34	247	89	synthetic	synthetic	ADJ
aji-34	247	90	dmards	dmard	NOUN
aji-34	247	91	.	.	PUNCT
aji-34	248	1	consent	consent	VERB
aji-34	248	2	it	it	PRON
aji-34	248	3	is	be	AUX
aji-34	248	4	not	not	PART
aji-34	248	5	applicable	applicable	ADJ
aji-34	248	6	.	.	PUNCT
aji-34	249	1	ethical	ethical	ADJ
aji-34	249	2	approval	approval	NOUN
aji-34	249	3	it	it	PRON
aji-34	249	4	is	be	AUX
aji-34	249	5	not	not	PART
aji-34	249	6	applicable	applicable	ADJ
aji-34	249	7	.	.	PUNCT
aji-34	250	1	competing	compete	VERB
aji-34	250	2	interests	interest	NOUN
aji-34	250	3	authors	author	NOUN
aji-34	250	4	have	have	AUX
aji-34	250	5	declared	declare	VERB
aji-34	250	6	that	that	SCONJ
aji-34	250	7	no	no	DET
aji-34	250	8	competing	compete	VERB
aji-34	250	9	interests	interest	NOUN
aji-34	250	10	exist	exist	VERB
aji-34	250	11	.	.	PUNCT
aji-34	251	1	references	reference	NOUN
aji-34	251	2	1	1	NUM
aji-34	251	3	.	.	PUNCT
aji-34	252	1	gulati	gulati	PROPN
aji-34	252	2	k	k	PROPN
aji-34	252	3	,	,	PUNCT
aji-34	252	4	guhathakurta	guhathakurta	PROPN
aji-34	252	5	s	s	PROPN
aji-34	252	6	,	,	PUNCT
aji-34	252	7	joshi	joshi	PROPN
aji-34	252	8	j	j	PROPN
aji-34	252	9	,	,	PUNCT
aji-34	252	10	rai	rai	PROPN
aji-34	252	11	n	n	CCONJ
aji-34	252	12	,	,	PUNCT
aji-34	252	13	ray	ray	NOUN
aji-34	252	14	a.	a.	NOUN
aji-34	252	15	cytokines	cytokine	NOUN
aji-34	252	16	and	and	CCONJ
aji-34	252	17	their	their	PRON
aji-34	252	18	role	role	NOUN
aji-34	252	19	in	in	ADP
aji-34	252	20	health	health	NOUN
aji-34	252	21	and	and	CCONJ
aji-34	252	22	disease	disease	PROPN
aji-34	252	23	:	:	PUNCT
aji-34	252	24	a	a	DET
aji-34	252	25	brief	brief	ADJ
aji-34	252	26	overview	overview	NOUN
aji-34	252	27	.	.	PUNCT
aji-34	253	1	moj	moj	PROPN
aji-34	253	2	immunology	immunology	NOUN
aji-34	253	3	.	.	PUNCT
aji-34	254	1	2016;4(2):00121	2016;4(2):00121	NUM
aji-34	254	2	.	.	NOUN
aji-34	254	3	2	2	NUM
aji-34	254	4	.	.	X
aji-34	254	5	bach	bach	PROPN
aji-34	254	6	ea	ea	PROPN
aji-34	254	7	,	,	PUNCT
aji-34	254	8	aguet	aguet	VERB
aji-34	254	9	m	m	PROPN
aji-34	254	10	,	,	PUNCT
aji-34	254	11	schreiber	schreiber	PROPN
aji-34	254	12	rd	rd	PROPN
aji-34	254	13	.	.	PUNCT
aji-34	255	1	the	the	DET
aji-34	255	2	ifn	ifn	PROPN
aji-34	255	3	γ	γ	PROPN
aji-34	255	4	receptor	receptor	NOUN
aji-34	255	5	:	:	PUNCT
aji-34	255	6	a	a	DET
aji-34	255	7	paradigm	paradigm	NOUN
aji-34	255	8	for	for	ADP
aji-34	255	9	cytokine	cytokine	ADJ
aji-34	255	10	receptor	receptor	NOUN
aji-34	255	11	signaling	signal	VERB
aji-34	255	12	.	.	PUNCT
aji-34	256	1	annual	annual	ADJ
aji-34	256	2	review	review	NOUN
aji-34	256	3	of	of	ADP
aji-34	256	4	immunology	immunology	NOUN
aji-34	256	5	.	.	PUNCT
aji-34	257	1	1997;15:563–591	1997;15:563–591	NOUN
aji-34	257	2	.	.	PUNCT
aji-34	258	1	3	3	X
aji-34	258	2	.	.	X
aji-34	258	3	chang	chang	PROPN
aji-34	258	4	jh	jh	PROPN
aji-34	258	5	,	,	PUNCT
aji-34	258	6	ryang	ryang	PROPN
aji-34	258	7	ys	ys	PROPN
aji-34	258	8	,	,	PUNCT
aji-34	258	9	morio	morio	PROPN
aji-34	258	10	t	t	PROPN
aji-34	258	11	,	,	PUNCT
aji-34	258	12	lee	lee	PROPN
aji-34	258	13	sk	sk	PROPN
aji-34	258	14	,	,	PUNCT
aji-34	258	15	chang	chang	PROPN
aji-34	258	16	ej	ej	PROPN
aji-34	258	17	.	.	PROPN
aji-34	258	18	trichomonasvaginalis	trichomonasvaginalis	PROPN
aji-34	258	19	inhibits	inhibit	VERB
aji-34	258	20	proinflammatory	proinflammatory	ADJ
aji-34	258	21	cytokine	cytokine	NOUN
aji-34	258	22	production	production	NOUN
aji-34	258	23	in	in	ADP
aji-34	258	24	macrophages	macrophage	NOUN
aji-34	258	25	by	by	ADP
aji-34	258	26	suppressing	suppress	VERB
aji-34	258	27	nf	nf	ADJ
aji-34	258	28	-	-	PUNCT
aji-34	258	29	kappab	kappab	NOUN
aji-34	258	30	activation	activation	NOUN
aji-34	258	31	.	.	PUNCT
aji-34	259	1	molecules	molecule	NOUN
aji-34	259	2	and	and	CCONJ
aji-34	259	3	cells	cell	NOUN
aji-34	259	4	.	.	PUNCT
aji-34	260	1	2004;18	2004;18	NUM
aji-34	260	2	:	:	PUNCT
aji-34	260	3	177–185	177–185	NUM
aji-34	260	4	.	.	X
aji-34	261	1	4	4	X
aji-34	261	2	.	.	X
aji-34	261	3	patterson	patterson	PROPN
aji-34	261	4	ph	ph	PROPN
aji-34	261	5	.	.	PROPN
aji-34	261	6	cytokines	cytokine	NOUN
aji-34	261	7	and	and	CCONJ
aji-34	261	8	cns	cns	PROPN
aji-34	261	9	development	development	NOUN
aji-34	261	10	.	.	PUNCT
aji-34	262	1	neuron	neuron	PROPN
aji-34	262	2	.	.	PUNCT
aji-34	263	1	2009;64(1):61	2009;64(1):61	NUM
aji-34	263	2	-	-	SYM
aji-34	263	3	78.2	78.2	NUM
aji-34	263	4	.	.	PUNCT
aji-34	264	1	5	5	NUM
aji-34	264	2	.	.	X
aji-34	264	3	ueda	ueda	PROPN
aji-34	264	4	t	t	PROPN
aji-34	264	5	,	,	PUNCT
aji-34	264	6	shimada	shimada	PROPN
aji-34	264	7	e	e	PROPN
aji-34	264	8	,	,	PUNCT
aji-34	264	9	urakawa	urakawa	PROPN
aji-34	264	10	t.	t.	PROPN
aji-34	264	11	serum	serum	PROPN
aji-34	264	12	levels	level	NOUN
aji-34	264	13	of	of	ADP
aji-34	264	14	cytokines	cytokine	NOUN
aji-34	264	15	in	in	ADP
aji-34	264	16	patients	patient	NOUN
aji-34	264	17	with	with	ADP
aji-34	264	18	colorectal	colorectal	ADJ
aji-34	264	19	cancer	cancer	NOUN
aji-34	264	20	:	:	PUNCT
aji-34	264	21	possible	possible	ADJ
aji-34	264	22	involvement	involvement	NOUN
aji-34	264	23	of	of	ADP
aji-34	264	24	interleukin-6	interleukin-6	NUM
aji-34	264	25	and	and	CCONJ
aji-34	264	26	interleukin-8	interleukin-8	NUM
aji-34	264	27	in	in	ADP
aji-34	264	28	hematogenous	hematogenous	ADJ
aji-34	264	29	metastasis	metastasis	NOUN
aji-34	264	30	.	.	PUNCT
aji-34	265	1	journal	journal	NOUN
aji-34	265	2	of	of	ADP
aji-34	265	3	gastroenterology	gastroenterology	NOUN
aji-34	265	4	.	.	PUNCT
aji-34	266	1	1994;29:423–429	1994;29:423–429	PROPN
aji-34	266	2	.	.	PROPN
aji-34	266	3	6	6	NUM
aji-34	266	4	.	.	PUNCT
aji-34	266	5	barnes	barnes	PROPN
aji-34	266	6	pj	pj	PROPN
aji-34	266	7	.	.	PUNCT
aji-34	267	1	the	the	DET
aji-34	267	2	cytokine	cytokine	ADJ
aji-34	267	3	network	network	NOUN
aji-34	267	4	in	in	ADP
aji-34	267	5	asthma	asthma	NOUN
aji-34	267	6	and	and	CCONJ
aji-34	267	7	chronic	chronic	ADJ
aji-34	267	8	obstructive	obstructive	ADJ
aji-34	267	9	pulmonary	pulmonary	ADJ
aji-34	267	10	disease	disease	NOUN
aji-34	267	11	.	.	PUNCT
aji-34	268	1	j	j	PROPN
aji-34	268	2	clin	clin	PROPN
aji-34	268	3	invest	invest	PROPN
aji-34	268	4	.	.	PUNCT
aji-34	269	1	2008;118(11):35463556.4	2008;118(11):35463556.4	X
aji-34	269	2	.	.	X
aji-34	270	1	7	7	X
aji-34	270	2	.	.	X
aji-34	270	3	gulati	gulati	PROPN
aji-34	270	4	k	k	PROPN
aji-34	270	5	,	,	PUNCT
aji-34	270	6	guhathakurta	guhathakurta	PROPN
aji-34	270	7	s	s	PROPN
aji-34	270	8	,	,	PUNCT
aji-34	270	9	joshi	joshi	PROPN
aji-34	270	10	j	j	PROPN
aji-34	270	11	,	,	PUNCT
aji-34	270	12	rai	rai	PROPN
aji-34	270	13	n	n	CCONJ
aji-34	270	14	,	,	PUNCT
aji-34	270	15	ray	ray	NOUN
aji-34	270	16	a.	a.	NOUN
aji-34	270	17	cytokines	cytokine	NOUN
aji-34	270	18	and	and	CCONJ
aji-34	270	19	their	their	PRON
aji-34	270	20	role	role	NOUN
aji-34	270	21	in	in	ADP
aji-34	270	22	health	health	NOUN
aji-34	270	23	and	and	CCONJ
aji-34	270	24	disease	disease	PROPN
aji-34	270	25	:	:	PUNCT
aji-34	270	26	a	a	DET
aji-34	270	27	brief	brief	ADJ
aji-34	270	28	overview	overview	NOUN
aji-34	270	29	.	.	PUNCT
aji-34	271	1	moj	moj	PROPN
aji-34	271	2	immunology	immunology	NOUN
aji-34	271	3	.	.	PUNCT
aji-34	272	1	2016;4(2):00121	2016;4(2):00121	NUM
aji-34	272	2	.	.	NOUN
aji-34	272	3	8	8	NUM
aji-34	272	4	.	.	X
aji-34	272	5	stephen	stephen	PROPN
aji-34	272	6	john	john	PROPN
aji-34	272	7	hopkins	hopkins	PROPN
aji-34	272	8	.	.	PUNCT
aji-34	273	1	the	the	DET
aji-34	273	2	pathophysiological	pathophysiological	ADJ
aji-34	273	3	role	role	NOUN
aji-34	273	4	of	of	ADP
aji-34	273	5	cytokines	cytokine	NOUN
aji-34	273	6	,	,	PUNCT
aji-34	273	7	legal	legal	ADJ
aji-34	273	8	medicine	medicine	NOUN
aji-34	273	9	,	,	PUNCT
aji-34	273	10	supplement	supplement	NOUN
aji-34	273	11	.	.	PUNCT
aji-34	274	1	2003;5:45	2003;5:45	NUM
aji-34	274	2	-	-	PUNCT
aji-34	274	3	s57	s57	NOUN
aji-34	274	4	.	.	PUNCT
aji-34	275	1	[	[	X
aji-34	275	2	issn	issn	NOUN
aji-34	275	3	:	:	PUNCT
aji-34	275	4	1344	1344	NUM
aji-34	275	5	-	-	SYM
aji-34	275	6	6223	6223	NUM
aji-34	275	7	]	]	PUNCT
aji-34	275	8	9	9	X
aji-34	275	9	.	.	X
aji-34	275	10	yadav	yadav	PROPN
aji-34	275	11	d	d	PROPN
aji-34	275	12	,	,	PUNCT
aji-34	275	13	sarvetnick	sarvetnick	VERB
aji-34	275	14	n.	n.	PROPN
aji-34	275	15	cytokines	cytokine	NOUN
aji-34	275	16	and	and	CCONJ
aji-34	275	17	autoimmunity	autoimmunity	NOUN
aji-34	275	18	:	:	PUNCT
aji-34	275	19	redundancy	redundancy	NOUN
aji-34	275	20	defines	define	VERB
aji-34	275	21	their	their	PRON
aji-34	275	22	complex	complex	ADJ
aji-34	275	23	nature	nature	NOUN
aji-34	275	24	,	,	PUNCT
aji-34	275	25	current	current	ADJ
aji-34	275	26	opinion	opinion	NOUN
aji-34	275	27	in	in	ADP
aji-34	275	28	immunology	immunology	NOUN
aji-34	275	29	.	.	PUNCT
aji-34	276	1	2003;15(6):697	2003;15(6):697	NUM
aji-34	276	2	-	-	PUNCT
aji-34	276	3	703	703	NUM
aji-34	276	4	.	.	PUNCT
aji-34	277	1	[	[	X
aji-34	277	2	issn	issn	NOUN
aji-34	277	3	:	:	PUNCT
aji-34	277	4	0952	0952	NUM
aji-34	277	5	-	-	SYM
aji-34	277	6	7915	7915	NUM
aji-34	277	7	]	]	PUNCT
aji-34	277	8	shehu	shehu	NOUN
aji-34	277	9	et	et	PROPN
aji-34	277	10	al	al	PROPN
aji-34	277	11	.	.	PROPN
aji-34	277	12	;	;	PUNCT
aji-34	277	13	aji	aji	PROPN
aji-34	277	14	,	,	PUNCT
aji-34	277	15	3(1	3(1	NUM
aji-34	277	16	):	):	PUNCT
aji-34	277	17	259	259	NUM
aji-34	277	18	-	-	SYM
aji-34	277	19	268	268	NUM
aji-34	277	20	,	,	PUNCT
aji-34	277	21	2020	2020	NUM
aji-34	277	22	;	;	PUNCT
aji-34	277	23	article	article	NOUN
aji-34	277	24	no.aji.57314	no.aji.57314	PROPN
aji-34	277	25	266	266	NUM
aji-34	277	26	10	10	NUM
aji-34	277	27	.	.	PUNCT
aji-34	278	1	li	li	PROPN
aji-34	278	2	h	h	PROPN
aji-34	278	3	,	,	PUNCT
aji-34	278	4	xie	xie	PROPN
aji-34	278	5	w	w	PROPN
aji-34	278	6	,	,	PUNCT
aji-34	278	7	strong	strong	PROPN
aji-34	278	8	ja	ja	PROPN
aji-34	278	9	,	,	PUNCT
aji-34	278	10	zhang	zhang	PROPN
aji-34	278	11	jm	jm	PROPN
aji-34	278	12	.	.	PROPN
aji-34	278	13	systemic	systemic	ADJ
aji-34	278	14	antiinflammatory	antiinflammatory	NOUN
aji-34	278	15	corticosteroid	corticosteroid	NOUN
aji-34	278	16	reduces	reduce	VERB
aji-34	278	17	mechanical	mechanical	ADJ
aji-34	278	18	pain	pain	NOUN
aji-34	278	19	behavior	behavior	NOUN
aji-34	278	20	,	,	PUNCT
aji-34	278	21	sympathetic	sympathetic	ADJ
aji-34	278	22	sprouting	sprouting	NOUN
aji-34	278	23	,	,	PUNCT
aji-34	278	24	and	and	CCONJ
aji-34	278	25	elevation	elevation	NOUN
aji-34	278	26	of	of	ADP
aji-34	278	27	proinflammatory	proinflammatory	ADJ
aji-34	278	28	cytokines	cytokine	NOUN
aji-34	278	29	in	in	ADP
aji-34	278	30	a	a	DET
aji-34	278	31	rat	rat	NOUN
aji-34	278	32	model	model	NOUN
aji-34	278	33	of	of	ADP
aji-34	278	34	neuropathic	neuropathic	ADJ
aji-34	278	35	pain	pain	NOUN
aji-34	278	36	.	.	PUNCT
aji-34	279	1	anesthesiology	anesthesiology	NOUN
aji-34	279	2	.	.	PUNCT
aji-34	280	1	2007	2007	NUM
aji-34	280	2	;	;	PUNCT
aji-34	280	3	107(3):469–477	107(3):469–477	NUM
aji-34	280	4	.	.	PUNCT
aji-34	281	1	11	11	NUM
aji-34	281	2	.	.	PUNCT
aji-34	282	1	chang	chang	PROPN
aji-34	282	2	jh	jh	PROPN
aji-34	282	3	,	,	PUNCT
aji-34	282	4	ryang	ryang	PROPN
aji-34	282	5	ys	ys	PROPN
aji-34	282	6	,	,	PUNCT
aji-34	282	7	morio	morio	PROPN
aji-34	282	8	t	t	PROPN
aji-34	282	9	,	,	PUNCT
aji-34	282	10	lee	lee	PROPN
aji-34	282	11	sk	sk	PROPN
aji-34	282	12	,	,	PUNCT
aji-34	282	13	chang	chang	PROPN
aji-34	282	14	ej	ej	PROPN
aji-34	282	15	.	.	PROPN
aji-34	282	16	trichomonasvaginalis	trichomonasvaginalis	PROPN
aji-34	282	17	inhibits	inhibit	VERB
aji-34	282	18	proinflammatory	proinflammatory	ADJ
aji-34	282	19	cytokine	cytokine	NOUN
aji-34	282	20	production	production	NOUN
aji-34	282	21	in	in	ADP
aji-34	282	22	macrophages	macrophage	NOUN
aji-34	282	23	by	by	ADP
aji-34	282	24	suppressing	suppress	VERB
aji-34	282	25	nf	nf	ADJ
aji-34	282	26	-	-	PUNCT
aji-34	282	27	kappab	kappab	NOUN
aji-34	282	28	activation	activation	NOUN
aji-34	282	29	.	.	PUNCT
aji-34	283	1	molecules	molecule	NOUN
aji-34	283	2	and	and	CCONJ
aji-34	283	3	cells	cell	NOUN
aji-34	283	4	.	.	PUNCT
aji-34	284	1	2004;18	2004;18	NUM
aji-34	284	2	:	:	PUNCT
aji-34	284	3	177–185	177–185	NUM
aji-34	284	4	.	.	X
aji-34	285	1	12	12	NUM
aji-34	285	2	.	.	PUNCT
aji-34	286	1	nielsen	nielsen	PROPN
aji-34	286	2	ar	ar	PROPN
aji-34	286	3	,	,	PUNCT
aji-34	286	4	pedersen	pedersen	PROPN
aji-34	286	5	bk	bk	PROPN
aji-34	286	6	.	.	PUNCT
aji-34	287	1	the	the	DET
aji-34	287	2	biological	biological	ADJ
aji-34	287	3	roles	role	NOUN
aji-34	287	4	of	of	ADP
aji-34	287	5	exercise	exercise	NOUN
aji-34	287	6	-	-	PUNCT
aji-34	287	7	induced	induce	VERB
aji-34	287	8	cytokines	cytokine	NOUN
aji-34	287	9	:	:	PUNCT
aji-34	287	10	il-6	il-6	NUM
aji-34	287	11	,	,	PUNCT
aji-34	287	12	il-8	il-8	NOUN
aji-34	287	13	,	,	PUNCT
aji-34	287	14	and	and	CCONJ
aji-34	287	15	il-15	il-15	X
aji-34	287	16	.	.	PUNCT
aji-34	288	1	applied	apply	VERB
aji-34	288	2	physiology	physiology	NOUN
aji-34	288	3	,	,	PUNCT
aji-34	288	4	nutrition	nutrition	NOUN
aji-34	288	5	,	,	PUNCT
aji-34	288	6	and	and	CCONJ
aji-34	288	7	metabolism	metabolism	NOUN
aji-34	288	8	.	.	PUNCT
aji-34	289	1	2007;32:833	2007;32:833	X
aji-34	289	2	–	–	PUNCT
aji-34	289	3	839	839	NUM
aji-34	289	4	.	.	PUNCT
aji-34	290	1	13	13	NUM
aji-34	290	2	.	.	PUNCT
aji-34	291	1	palomo	palomo	PROPN
aji-34	291	2	j	j	PROPN
aji-34	291	3	,	,	PUNCT
aji-34	291	4	dietrich	dietrich	PROPN
aji-34	291	5	d	d	PROPN
aji-34	291	6	,	,	PUNCT
aji-34	291	7	martin	martin	PROPN
aji-34	291	8	p	p	X
aji-34	291	9	,	,	PUNCT
aji-34	291	10	palmer	palmer	PROPN
aji-34	291	11	g	g	NOUN
aji-34	291	12	,	,	PUNCT
aji-34	291	13	gabay	gabay	PROPN
aji-34	291	14	c.	c.	NOUN
aji-34	291	15	the	the	DET
aji-34	291	16	interleukin	interleukin	NOUN
aji-34	291	17	(	(	PUNCT
aji-34	291	18	il)-1	il)-1	ADP
aji-34	291	19	cytokine	cytokine	ADJ
aji-34	291	20	family	family	NOUN
aji-34	291	21	–	–	PUNCT
aji-34	291	22	balance	balance	NOUN
aji-34	291	23	between	between	ADP
aji-34	291	24	agonists	agonist	NOUN
aji-34	291	25	and	and	CCONJ
aji-34	291	26	antagonists	antagonist	NOUN
aji-34	291	27	in	in	ADP
aji-34	291	28	inflammatory	inflammatory	ADJ
aji-34	291	29	diseases	disease	NOUN
aji-34	291	30	,	,	PUNCT
aji-34	291	31	cytokine	cytokine	NOUN
aji-34	291	32	.	.	PUNCT
aji-34	292	1	2015;76(1):25	2015;76(1):25	X
aji-34	292	2	-	-	SYM
aji-34	292	3	37	37	NUM
aji-34	292	4	.	.	PUNCT
aji-34	293	1	[	[	X
aji-34	293	2	issn	issn	NOUN
aji-34	293	3	:	:	PUNCT
aji-34	293	4	1043	1043	NUM
aji-34	293	5	-	-	SYM
aji-34	293	6	4666	4666	NUM
aji-34	293	7	]	]	PUNCT
aji-34	293	8	14	14	NUM
aji-34	293	9	.	.	PUNCT
aji-34	294	1	dinarello	dinarello	PROPN
aji-34	294	2	ca	ca	PROPN
aji-34	294	3	.	.	PUNCT
aji-34	295	1	historical	historical	ADJ
aji-34	295	2	insights	insight	NOUN
aji-34	295	3	into	into	ADP
aji-34	295	4	cytokines	cytokine	NOUN
aji-34	295	5	.	.	PUNCT
aji-34	296	1	european	european	ADJ
aji-34	296	2	journal	journal	PROPN
aji-34	296	3	of	of	ADP
aji-34	296	4	immunology	immunology	NOUN
aji-34	296	5	.	.	PUNCT
aji-34	297	1	2007;37(suppl	2007;37(suppl	NOUN
aji-34	297	2	1):s34	1):s34	NUM
aji-34	297	3	–	–	PUNCT
aji-34	297	4	s45	s45	VERB
aji-34	297	5	.	.	PUNCT
aji-34	298	1	15	15	NUM
aji-34	298	2	.	.	PUNCT
aji-34	299	1	braddock	braddock	PROPN
aji-34	299	2	m	m	PROPN
aji-34	299	3	,	,	PUNCT
aji-34	299	4	quinn	quinn	NOUN
aji-34	299	5	a.	a.	NOUN
aji-34	299	6	targeting	targeting	NOUN
aji-34	299	7	il-1	il-1	ADV
aji-34	299	8	in	in	ADP
aji-34	299	9	inflammatory	inflammatory	ADJ
aji-34	299	10	disease	disease	NOUN
aji-34	299	11	:	:	PUNCT
aji-34	299	12	new	new	ADJ
aji-34	299	13	opportunities	opportunity	NOUN
aji-34	299	14	for	for	ADP
aji-34	299	15	therapeutic	therapeutic	ADJ
aji-34	299	16	intervention	intervention	NOUN
aji-34	299	17	.	.	PUNCT
aji-34	300	1	nature	nature	NOUN
aji-34	300	2	reviews	review	NOUN
aji-34	300	3	.	.	PUNCT
aji-34	301	1	drug	drug	NOUN
aji-34	301	2	discovery	discovery	NOUN
aji-34	301	3	.	.	PUNCT
aji-34	302	1	2004;3:330	2004;3:330	NUM
aji-34	302	2	–	–	PUNCT
aji-34	302	3	339	339	NUM
aji-34	302	4	.	.	PUNCT
aji-34	303	1	16	16	NUM
aji-34	303	2	.	.	PUNCT
aji-34	304	1	vasanthi	vasanthi	PROPN
aji-34	304	2	p	p	PROPN
aji-34	304	3	,	,	PUNCT
aji-34	304	4	nalini	nalini	PROPN
aji-34	304	5	g	g	PROPN
aji-34	304	6	,	,	PUNCT
aji-34	304	7	rajasekhar	rajasekhar	PROPN
aji-34	304	8	g	g	PROPN
aji-34	304	9	,	,	PUNCT
aji-34	304	10	the	the	DET
aji-34	304	11	vasanthi	vasanthi	NOUN
aji-34	304	12	.	.	PUNCT
aji-34	305	1	role	role	NOUN
aji-34	305	2	of	of	ADP
aji-34	305	3	tumor	tumor	NOUN
aji-34	305	4	necrosis	necrosis	NOUN
aji-34	305	5	factor‐alpha	factor‐alpha	NOUN
aji-34	305	6	in	in	ADP
aji-34	305	7	rheumatoid	rheumatoid	NOUN
aji-34	305	8	arthritis	arthritis	NOUN
aji-34	305	9	:	:	PUNCT
aji-34	305	10	a	a	DET
aji-34	305	11	review	review	NOUN
aji-34	305	12	.	.	PUNCT
aji-34	306	1	aplar	aplar	ADJ
aji-34	306	2	journal	journal	PROPN
aji-34	306	3	of	of	ADP
aji-34	306	4	rheumatology	rheumatology	NOUN
aji-34	306	5	.	.	PUNCT
aji-34	307	1	2007;10”270–274	2007;10”270–274	X
aji-34	307	2	.	.	X
aji-34	307	3	17	17	NUM
aji-34	307	4	.	.	PUNCT
aji-34	307	5	mcgeehan	mcgeehan	PROPN
aji-34	307	6	gm	gm	PROPN
aji-34	307	7	,	,	PUNCT
aji-34	307	8	becherer	becherer	PROPN
aji-34	307	9	jd	jd	PROPN
aji-34	307	10	,	,	PUNCT
aji-34	307	11	bast	bast	PROPN
aji-34	307	12	rc	rc	PROPN
aji-34	307	13	,	,	PUNCT
aji-34	307	14	jr	jr	PROPN
aji-34	307	15	.	.	PROPN
aji-34	307	16	,	,	PUNCT
aji-34	307	17	boyer	boyer	PROPN
aji-34	307	18	cm	cm	PROPN
aji-34	307	19	,	,	PUNCT
aji-34	307	20	champion	champion	NOUN
aji-34	307	21	b	b	PROPN
aji-34	307	22	,	,	PUNCT
aji-34	307	23	connolly	connolly	PROPN
aji-34	307	24	km	km	PROPN
aji-34	307	25	,	,	PUNCT
aji-34	307	26	conway	conway	PROPN
aji-34	307	27	jg	jg	PROPN
aji-34	307	28	,	,	PUNCT
aji-34	307	29	furdon	furdon	NOUN
aji-34	307	30	p	p	NOUN
aji-34	307	31	,	,	PUNCT
aji-34	307	32	karp	karp	PROPN
aji-34	307	33	s	s	PROPN
aji-34	307	34	,	,	PUNCT
aji-34	307	35	kidao	kidao	PROPN
aji-34	307	36	s	s	PROPN
aji-34	307	37	,	,	PUNCT
aji-34	307	38	mcelroy	mcelroy	PROPN
aji-34	307	39	ab	ab	PROPN
aji-34	307	40	,	,	PUNCT
aji-34	307	41	nichols	nichols	PROPN
aji-34	307	42	j	j	PROPN
aji-34	307	43	,	,	PUNCT
aji-34	307	44	pryzwansky	pryzwansky	PROPN
aji-34	307	45	km	km	PROPN
aji-34	307	46	,	,	PUNCT
aji-34	307	47	schoenen	schoenen	PROPN
aji-34	307	48	f	f	PROPN
aji-34	307	49	,	,	PUNCT
aji-34	307	50	sekut	sekut	ADJ
aji-34	307	51	l	l	NOUN
aji-34	307	52	,	,	PUNCT
aji-34	307	53	truesdale	truesdale	PROPN
aji-34	307	54	a	a	PRON
aji-34	307	55	,	,	PUNCT
aji-34	307	56	verghese	verghese	PROPN
aji-34	307	57	m	m	PROPN
aji-34	307	58	,	,	PUNCT
aji-34	307	59	warner	warner	PROPN
aji-34	307	60	j	j	PROPN
aji-34	307	61	,	,	PUNCT
aji-34	307	62	ways	way	NOUN
aji-34	307	63	jp	jp	NOUN
aji-34	307	64	.	.	PUNCT
aji-34	308	1	regulation	regulation	NOUN
aji-34	308	2	of	of	ADP
aji-34	308	3	tumour	tumour	NOUN
aji-34	308	4	necrosis	necrosis	NOUN
aji-34	308	5	factor	factor	NOUN
aji-34	308	6	-	-	PUNCT
aji-34	308	7	alpha	alpha	NOUN
aji-34	308	8	processing	processing	NOUN
aji-34	308	9	by	by	ADP
aji-34	308	10	a	a	DET
aji-34	308	11	metalloproteinase	metalloproteinase	NOUN
aji-34	308	12	inhibitor	inhibitor	NOUN
aji-34	308	13	.	.	PUNCT
aji-34	309	1	nature	nature	NOUN
aji-34	309	2	.	.	PUNCT
aji-34	310	1	1994;370:558–561	1994;370:558–561	X
aji-34	310	2	.	.	PUNCT
aji-34	311	1	18	18	NUM
aji-34	311	2	.	.	PUNCT
aji-34	312	1	lai	lai	PROPN
aji-34	312	2	ns	ns	PROPN
aji-34	312	3	,	,	PUNCT
aji-34	312	4	yu	yu	PROPN
aji-34	312	5	hc	hc	PROPN
aji-34	312	6	,	,	PUNCT
aji-34	312	7	tung	tung	PROPN
aji-34	312	8	ch	ch	PROPN
aji-34	312	9	,	,	PUNCT
aji-34	312	10	huang	huang	PROPN
aji-34	312	11	ky	ky	PROPN
aji-34	312	12	,	,	PUNCT
aji-34	312	13	huang	huang	PROPN
aji-34	312	14	hb	hb	PROPN
aji-34	312	15	,	,	PUNCT
aji-34	312	16	lu	lu	PROPN
aji-34	312	17	mc	mc	PROPN
aji-34	312	18	.	.	PUNCT
aji-34	313	1	the	the	DET
aji-34	313	2	role	role	NOUN
aji-34	313	3	of	of	ADP
aji-34	313	4	aberrant	aberrant	ADJ
aji-34	313	5	expression	expression	NOUN
aji-34	313	6	of	of	ADP
aji-34	313	7	t	t	PROPN
aji-34	313	8	cell	cell	NOUN
aji-34	313	9	mirnas	mirna	NOUN
aji-34	313	10	affected	affect	VERB
aji-34	313	11	by	by	ADP
aji-34	313	12	tnf	tnf	PROPN
aji-34	313	13	-	-	PUNCT
aji-34	313	14	α	α	PROPN
aji-34	313	15	in	in	ADP
aji-34	313	16	the	the	DET
aji-34	313	17	immunopathogenesis	immunopathogenesis	NOUN
aji-34	313	18	of	of	ADP
aji-34	313	19	rheumatoid	rheumatoid	NOUN
aji-34	313	20	arthritis	arthritis	NOUN
aji-34	313	21	.	.	PUNCT
aji-34	314	1	arthritis	arthritis	NOUN
aji-34	314	2	res	re	NOUN
aji-34	314	3	ther	ther	ADV
aji-34	314	4	.	.	PUNCT
aji-34	315	1	2017;19(1):261	2017;19(1):261	NUM
aji-34	315	2	.	.	PROPN
aji-34	315	3	19	19	NUM
aji-34	315	4	.	.	PUNCT
aji-34	315	5	newton	newton	PROPN
aji-34	315	6	rc	rc	PROPN
aji-34	315	7	,	,	PUNCT
aji-34	315	8	solomon	solomon	PROPN
aji-34	315	9	ka	ka	PROPN
aji-34	315	10	,	,	PUNCT
aji-34	315	11	covington	covington	PROPN
aji-34	315	12	mb	mb	PROPN
aji-34	315	13	,	,	PUNCT
aji-34	315	14	et	et	PROPN
aji-34	315	15	al	al	PROPN
aji-34	315	16	.	.	PROPN
aji-34	315	17	biology	biology	NOUN
aji-34	315	18	of	of	ADP
aji-34	315	19	tace	tace	NOUN
aji-34	315	20	inhibition	inhibition	NOUN
aji-34	315	21	.	.	PUNCT
aji-34	316	1	ann	ann	PROPN
aji-34	316	2	rheum	rheum	PROPN
aji-34	316	3	dis	dis	PROPN
aji-34	316	4	.	.	PUNCT
aji-34	317	1	2001;60(suppl	2001;60(suppl	PROPN
aji-34	317	2	3):iii25	3):iii25	PROPN
aji-34	317	3	–	–	PUNCT
aji-34	317	4	iii32	iii32	PROPN
aji-34	317	5	.	.	PUNCT
aji-34	318	1	doi	doi	NOUN
aji-34	318	2	:	:	PUNCT
aji-34	318	3	10.1136	10.1136	NUM
aji-34	318	4	/	/	SYM
aji-34	318	5	ard.60.90003.iii25	ard.60.90003.iii25	DET
aji-34	318	6	20	20	NUM
aji-34	318	7	.	.	PUNCT
aji-34	319	1	nawroth	nawroth	PROPN
aji-34	319	2	pp	pp	PROPN
aji-34	319	3	,	,	PUNCT
aji-34	319	4	bank	bank	PROPN
aji-34	319	5	i	i	PROPN
aji-34	319	6	,	,	PUNCT
aji-34	319	7	handley	handley	PROPN
aji-34	319	8	d	d	PROPN
aji-34	319	9	,	,	PUNCT
aji-34	319	10	cassimeris	cassimeris	PROPN
aji-34	319	11	j	j	PROPN
aji-34	319	12	,	,	PUNCT
aji-34	319	13	chess	chess	NOUN
aji-34	319	14	l	l	NOUN
aji-34	319	15	,	,	PUNCT
aji-34	319	16	stern	stern	PROPN
aji-34	319	17	d.	d.	PROPN
aji-34	319	18	tumor	tumor	PROPN
aji-34	319	19	necrosis	necrosis	NOUN
aji-34	319	20	factor	factor	NOUN
aji-34	319	21	/	/	SYM
aji-34	319	22	cachectin	cachectin	NOUN
aji-34	319	23	interacts	interact	VERB
aji-34	319	24	with	with	ADP
aji-34	319	25	endothelial	endothelial	ADJ
aji-34	319	26	cell	cell	NOUN
aji-34	319	27	receptors	receptor	NOUN
aji-34	319	28	to	to	PART
aji-34	319	29	induce	induce	VERB
aji-34	319	30	release	release	NOUN
aji-34	319	31	of	of	ADP
aji-34	319	32	interleukin	interleukin	NOUN
aji-34	319	33	1	1	NUM
aji-34	319	34	.	.	PUNCT
aji-34	320	1	the	the	DET
aji-34	320	2	journal	journal	NOUN
aji-34	320	3	of	of	ADP
aji-34	320	4	experimental	experimental	ADJ
aji-34	320	5	medicine	medicine	NOUN
aji-34	320	6	.	.	PUNCT
aji-34	321	1	1986;163:1363	1986;163:1363	NUM
aji-34	321	2	–	–	PUNCT
aji-34	321	3	1375	1375	NUM
aji-34	321	4	.	.	PUNCT
aji-34	322	1	21	21	NUM
aji-34	322	2	.	.	PUNCT
aji-34	322	3	simpson	simpson	PROPN
aji-34	322	4	rj	rj	PROPN
aji-34	322	5	,	,	PUNCT
aji-34	322	6	hammacher	hammacher	PROPN
aji-34	322	7	a	a	PROPN
aji-34	322	8	,	,	PUNCT
aji-34	322	9	smith	smith	PROPN
aji-34	322	10	dk	dk	PROPN
aji-34	322	11	,	,	PUNCT
aji-34	322	12	matthews	matthews	PROPN
aji-34	322	13	jm	jm	PROPN
aji-34	322	14	,	,	PUNCT
aji-34	322	15	war	war	PROPN
aji-34	322	16	ld	ld	PROPN
aji-34	322	17	.	.	PUNCT
aji-34	323	1	interleukin-6	interleukin-6	PROPN
aji-34	323	2	:	:	PUNCT
aji-34	323	3	structure	structure	NOUN
aji-34	323	4	-	-	PUNCT
aji-34	323	5	function	function	NOUN
aji-34	323	6	relationships	relationship	NOUN
aji-34	323	7	.	.	PUNCT
aji-34	324	1	protein	protein	NOUN
aji-34	324	2	science	science	NOUN
aji-34	324	3	.	.	PUNCT
aji-34	325	1	1997;6:929–955	1997;6:929–955	NUM
aji-34	325	2	.	.	PUNCT
aji-34	326	1	22	22	NUM
aji-34	326	2	.	.	PUNCT
aji-34	327	1	o’reilly	o’reilly	PROPN
aji-34	327	2	s	s	PART
aji-34	327	3	,	,	PUNCT
aji-34	327	4	ca	can	AUX
aji-34	327	5	nt	not	PART
aji-34	327	6	r	r	NOUN
aji-34	327	7	,	,	PUNCT
aji-34	327	8	ciechomska	ciechomska	NOUN
aji-34	327	9	m	m	PROPN
aji-34	327	10	,	,	PUNCT
aji-34	327	11	van	van	PROPN
aji-34	327	12	laar	laar	PROPN
aji-34	327	13	jm	jm	PROPN
aji-34	327	14	.	.	PROPN
aji-34	328	1	interleukin-6	interleukin-6	PROPN
aji-34	328	2	:	:	PUNCT
aji-34	328	3	a	a	DET
aji-34	328	4	new	new	ADJ
aji-34	328	5	therapeutic	therapeutic	ADJ
aji-34	328	6	target	target	NOUN
aji-34	328	7	in	in	ADP
aji-34	328	8	systemic	systemic	ADJ
aji-34	328	9	sclerosis	sclerosis	NOUN
aji-34	328	10	?	?	PUNCT
aji-34	329	1	clinical	clinical	ADJ
aji-34	329	2	&	&	CCONJ
aji-34	329	3	translational	translational	ADJ
aji-34	329	4	immunology	immunology	NOUN
aji-34	329	5	.	.	PUNCT
aji-34	330	1	2013;2	2013;2	NUM
aji-34	330	2	:	:	PUNCT
aji-34	330	3	e4	e4	PROPN
aji-34	330	4	.	.	PUNCT
aji-34	331	1	23	23	NUM
aji-34	331	2	.	.	PUNCT
aji-34	332	1	hirano	hirano	PROPN
aji-34	332	2	t	t	PROPN
aji-34	332	3	,	,	PUNCT
aji-34	332	4	taga	taga	PROPN
aji-34	332	5	t	t	PROPN
aji-34	332	6	,	,	PUNCT
aji-34	332	7	matsuda	matsuda	PROPN
aji-34	332	8	t	t	PROPN
aji-34	332	9	,	,	PUNCT
aji-34	332	10	hibi	hibi	PROPN
aji-34	332	11	m	m	PROPN
aji-34	332	12	,	,	PUNCT
aji-34	332	13	suematsu	suematsu	PROPN
aji-34	332	14	s	s	PROPN
aji-34	332	15	,	,	PUNCT
aji-34	332	16	tang	tang	PROPN
aji-34	332	17	b	b	NOUN
aji-34	332	18	,	,	PUNCT
aji-34	332	19	murakami	murakami	PROPN
aji-34	332	20	m	m	PROPN
aji-34	332	21	,	,	PUNCT
aji-34	332	22	kishimoto	kishimoto	PROPN
aji-34	332	23	t.	t.	PROPN
aji-34	332	24	interleukin	interleukin	NOUN
aji-34	332	25	6	6	NUM
aji-34	332	26	and	and	CCONJ
aji-34	332	27	its	its	PRON
aji-34	332	28	receptor	receptor	NOUN
aji-34	332	29	in	in	ADP
aji-34	332	30	the	the	DET
aji-34	332	31	immune	immune	ADJ
aji-34	332	32	response	response	NOUN
aji-34	332	33	and	and	CCONJ
aji-34	332	34	hematopoiesis	hematopoiesis	NOUN
aji-34	332	35	.	.	PUNCT
aji-34	333	1	international	international	ADJ
aji-34	333	2	journal	journal	NOUN
aji-34	333	3	of	of	ADP
aji-34	333	4	cell	cell	NOUN
aji-34	333	5	cloning	cloning	NOUN
aji-34	333	6	.	.	PUNCT
aji-34	334	1	1990;8(suppl	1990;8(suppl	NUM
aji-34	335	1	1):155–166	1):155–166	NUM
aji-34	335	2	.	.	PUNCT
aji-34	336	1	24	24	NUM
aji-34	336	2	.	.	PUNCT
aji-34	337	1	ataie	ataie	PROPN
aji-34	337	2	-	-	PUNCT
aji-34	337	3	kachoie	kachoie	PROPN
aji-34	337	4	p	p	NOUN
aji-34	337	5	,	,	PUNCT
aji-34	337	6	pourgholami	pourgholami	PROPN
aji-34	337	7	mh	mh	PROPN
aji-34	337	8	,	,	PUNCT
aji-34	337	9	morris	morris	PROPN
aji-34	337	10	dl	dl	PROPN
aji-34	337	11	.	.	PROPN
aji-34	337	12	inhibition	inhibition	NOUN
aji-34	337	13	of	of	ADP
aji-34	337	14	the	the	DET
aji-34	337	15	il-6	il-6	NOUN
aji-34	337	16	signaling	signal	VERB
aji-34	337	17	pathway	pathway	NOUN
aji-34	337	18	:	:	PUNCT
aji-34	337	19	a	a	DET
aji-34	337	20	strategy	strategy	NOUN
aji-34	337	21	to	to	PART
aji-34	337	22	combat	combat	VERB
aji-34	337	23	chronic	chronic	ADJ
aji-34	337	24	inflammatory	inflammatory	ADJ
aji-34	337	25	diseases	disease	NOUN
aji-34	337	26	and	and	CCONJ
aji-34	337	27	cancer	cancer	NOUN
aji-34	337	28	.	.	PUNCT
aji-34	338	1	cytokine	cytokine	VERB
aji-34	338	2	&	&	CCONJ
aji-34	338	3	growth	growth	NOUN
aji-34	338	4	factor	factor	NOUN
aji-34	338	5	reviews	review	NOUN
aji-34	338	6	.	.	PUNCT
aji-34	339	1	2013;24:163–173	2013;24:163–173	NUM
aji-34	339	2	.	.	PUNCT
aji-34	340	1	25	25	NUM
aji-34	340	2	.	.	PUNCT
aji-34	341	1	hibi	hibi	PROPN
aji-34	341	2	m	m	PROPN
aji-34	341	3	,	,	PUNCT
aji-34	341	4	murakami	murakami	PROPN
aji-34	341	5	m	m	PROPN
aji-34	341	6	,	,	PUNCT
aji-34	341	7	saito	saito	PROPN
aji-34	341	8	m	m	PROPN
aji-34	341	9	,	,	PUNCT
aji-34	341	10	hirano	hirano	PROPN
aji-34	341	11	t	t	PROPN
aji-34	341	12	,	,	PUNCT
aji-34	341	13	taga	taga	PROPN
aji-34	341	14	t	t	PROPN
aji-34	341	15	,	,	PUNCT
aji-34	341	16	kishimoto	kishimoto	PROPN
aji-34	341	17	t.	t.	PROPN
aji-34	341	18	molecular	molecular	ADJ
aji-34	341	19	cloning	cloning	NOUN
aji-34	341	20	and	and	CCONJ
aji-34	341	21	expression	expression	NOUN
aji-34	341	22	of	of	ADP
aji-34	341	23	an	an	DET
aji-34	341	24	il-6	il-6	NUM
aji-34	341	25	signal	signal	NOUN
aji-34	341	26	transducer	transducer	NOUN
aji-34	341	27	,	,	PUNCT
aji-34	341	28	gp130	gp130	PROPN
aji-34	341	29	.	.	PUNCT
aji-34	341	30	cell	cell	NOUN
aji-34	341	31	.	.	PUNCT
aji-34	342	1	1990;63:1149	1990;63:1149	NUM
aji-34	342	2	–	–	PUNCT
aji-34	342	3	1157	1157	NUM
aji-34	342	4	.	.	PUNCT
aji-34	343	1	26	26	NUM
aji-34	343	2	.	.	PUNCT
aji-34	344	1	kishimoto	kishimoto	PROPN
aji-34	344	2	t	t	PROPN
aji-34	344	3	,	,	PUNCT
aji-34	344	4	akira	akira	PROPN
aji-34	344	5	s	s	PROPN
aji-34	344	6	,	,	PUNCT
aji-34	344	7	taga	taga	NOUN
aji-34	344	8	t.	t.	PROPN
aji-34	344	9	interleukin-6	interleukin-6	PROPN
aji-34	344	10	and	and	CCONJ
aji-34	344	11	its	its	PRON
aji-34	344	12	receptor	receptor	NOUN
aji-34	344	13	:	:	PUNCT
aji-34	344	14	a	a	DET
aji-34	344	15	paradigm	paradigm	NOUN
aji-34	344	16	for	for	ADP
aji-34	344	17	cytokines	cytokine	NOUN
aji-34	344	18	.	.	PUNCT
aji-34	345	1	science	science	NOUN
aji-34	345	2	.	.	PUNCT
aji-34	346	1	1991;258:593–597	1991;258:593–597	NUM
aji-34	346	2	.	.	X
aji-34	347	1	27	27	NUM
aji-34	347	2	.	.	PUNCT
aji-34	348	1	taga	taga	PROPN
aji-34	348	2	t	t	PROPN
aji-34	348	3	,	,	PUNCT
aji-34	348	4	hibi	hibi	PROPN
aji-34	348	5	m	m	PROPN
aji-34	348	6	,	,	PUNCT
aji-34	348	7	hirata	hirata	ADJ
aji-34	348	8	y	y	PROPN
aji-34	348	9	,	,	PUNCT
aji-34	348	10	yamasaki	yamasaki	PROPN
aji-34	348	11	k	k	PROPN
aji-34	348	12	,	,	PUNCT
aji-34	348	13	yasukawa	yasukawa	PROPN
aji-34	348	14	k	k	PROPN
aji-34	348	15	,	,	PUNCT
aji-34	348	16	matsuda	matsuda	PROPN
aji-34	348	17	t	t	PROPN
aji-34	348	18	,	,	PUNCT
aji-34	348	19	hirano	hirano	PROPN
aji-34	348	20	t	t	PROPN
aji-34	348	21	,	,	PUNCT
aji-34	348	22	kishimoto	kishimoto	PROPN
aji-34	348	23	t.	t.	PROPN
aji-34	348	24	interleukin-6	interleukin-6	PROPN
aji-34	348	25	triggers	trigger	VERB
aji-34	348	26	the	the	DET
aji-34	348	27	association	association	NOUN
aji-34	348	28	of	of	ADP
aji-34	348	29	its	its	PRON
aji-34	348	30	receptor	receptor	NOUN
aji-34	348	31	with	with	ADP
aji-34	348	32	a	a	DET
aji-34	348	33	possible	possible	ADJ
aji-34	348	34	signal	signal	NOUN
aji-34	348	35	transducer	transducer	NOUN
aji-34	348	36	,	,	PUNCT
aji-34	348	37	gp130	gp130	PROPN
aji-34	348	38	.	.	PUNCT
aji-34	349	1	cell	cell	NOUN
aji-34	349	2	.	.	PUNCT
aji-34	350	1	1989;58	1989;58	NUM
aji-34	350	2	:	:	PUNCT
aji-34	351	1	573–581	573–581	NUM
aji-34	351	2	.	.	NOUN
aji-34	352	1	28	28	NUM
aji-34	352	2	.	.	PUNCT
aji-34	353	1	stahl	stahl	PROPN
aji-34	353	2	n	n	CCONJ
aji-34	353	3	,	,	PUNCT
aji-34	353	4	boulton	boulton	PROPN
aji-34	353	5	tg	tg	PROPN
aji-34	353	6	,	,	PUNCT
aji-34	353	7	farruggella	farruggella	PROPN
aji-34	353	8	t	t	PROPN
aji-34	353	9	,	,	PUNCT
aji-34	353	10	ip	ip	PRON
aji-34	353	11	n.	n.	PROPN
aji-34	353	12	y	y	PROPN
aji-34	353	13	,	,	PUNCT
aji-34	353	14	davis	davis	PROPN
aji-34	353	15	s	s	PROPN
aji-34	353	16	,	,	PUNCT
aji-34	353	17	witthuhn	witthuhn	PROPN
aji-34	353	18	ba	ba	PROPN
aji-34	353	19	,	,	PUNCT
aji-34	353	20	quelle	quelle	PROPN
aji-34	353	21	fw	fw	PROPN
aji-34	353	22	,	,	PUNCT
aji-34	353	23	silvennoinen	silvennoinen	NOUN
aji-34	353	24	o	o	NOUN
aji-34	353	25	,	,	PUNCT
aji-34	353	26	barbieri	barbieri	PROPN
aji-34	353	27	g	g	PROPN
aji-34	353	28	,	,	PUNCT
aji-34	353	29	pellegrini	pellegrini	PROPN
aji-34	353	30	s	s	PROPN
aji-34	353	31	,	,	PUNCT
aji-34	353	32	ihle	ihle	PROPN
aji-34	353	33	jn	jn	PROPN
aji-34	353	34	,	,	PUNCT
aji-34	353	35	yancopoulos	yancopoulos	PROPN
aji-34	353	36	gd	gd	PROPN
aji-34	353	37	.	.	PUNCT
aji-34	353	38	association	association	NOUN
aji-34	353	39	and	and	CCONJ
aji-34	353	40	activation	activation	NOUN
aji-34	353	41	of	of	ADP
aji-34	353	42	jak	jak	PROPN
aji-34	353	43	-	-	PUNCT
aji-34	353	44	tyk	tyk	PROPN
aji-34	353	45	kinases	kinase	NOUN
aji-34	353	46	by	by	ADP
aji-34	353	47	cntflif	cntflif	VERB
aji-34	353	48	-	-	PUNCT
aji-34	353	49	osm	osm	PROPN
aji-34	353	50	-	-	PUNCT
aji-34	353	51	il-6	il-6	NOUN
aji-34	353	52	β	β	NOUN
aji-34	353	53	receptor	receptor	NOUN
aji-34	353	54	components	component	NOUN
aji-34	353	55	.	.	PUNCT
aji-34	354	1	science	science	NOUN
aji-34	354	2	.	.	PUNCT
aji-34	355	1	1994;263:92–95	1994;263:92–95	NUM
aji-34	355	2	.	.	PROPN
aji-34	355	3	29	29	NUM
aji-34	355	4	.	.	PUNCT
aji-34	356	1	zhong	zhong	PROPN
aji-34	356	2	z	z	PROPN
aji-34	356	3	,	,	PUNCT
aji-34	356	4	wen	wen	PROPN
aji-34	356	5	z	z	PROPN
aji-34	356	6	,	,	PUNCT
aji-34	356	7	darnell	darnell	PROPN
aji-34	356	8	je	je	PROPN
aji-34	356	9	,	,	PUNCT
aji-34	356	10	jr	jr	PROPN
aji-34	356	11	.	.	PUNCT
aji-34	356	12	stat3	stat3	PROPN
aji-34	356	13	:	:	PUNCT
aji-34	356	14	a	a	DET
aji-34	356	15	stat	stat	PROPN
aji-34	356	16	family	family	NOUN
aji-34	356	17	member	member	NOUN
aji-34	356	18	activated	activate	VERB
aji-34	356	19	by	by	ADP
aji-34	356	20	tyrosine	tyrosine	NOUN
aji-34	356	21	phosphorylation	phosphorylation	NOUN
aji-34	356	22	in	in	ADP
aji-34	356	23	response	response	NOUN
aji-34	356	24	to	to	ADP
aji-34	356	25	epidermal	epidermal	ADJ
aji-34	356	26	growth	growth	NOUN
aji-34	356	27	factor	factor	NOUN
aji-34	356	28	and	and	CCONJ
aji-34	356	29	interleukin-6	interleukin-6	PROPN
aji-34	356	30	.	.	PUNCT
aji-34	357	1	science	science	NOUN
aji-34	357	2	.	.	PUNCT
aji-34	358	1	1994;264:95–98	1994;264:95–98	NUM
aji-34	358	2	.	.	NOUN
aji-34	359	1	30	30	NUM
aji-34	359	2	.	.	PUNCT
aji-34	360	1	ihle	ihle	PROPN
aji-34	360	2	jn	jn	PROPN
aji-34	360	3	,	,	PUNCT
aji-34	360	4	witthuhn	witthuhn	PROPN
aji-34	360	5	ba	ba	PROPN
aji-34	360	6	,	,	PUNCT
aji-34	360	7	quelle	quelle	PROPN
aji-34	360	8	fw	fw	PROPN
aji-34	360	9	,	,	PUNCT
aji-34	360	10	yamamoto	yamamoto	PROPN
aji-34	360	11	k	k	PROPN
aji-34	360	12	,	,	PUNCT
aji-34	360	13	thierfelder	thierfelder	VERB
aji-34	360	14	we	we	PRON
aji-34	360	15	,	,	PUNCT
aji-34	360	16	kreider	kreider	PROPN
aji-34	360	17	b	b	PROPN
aji-34	360	18	,	,	PUNCT
aji-34	360	19	silvennoinen	silvennoinen	NOUN
aji-34	360	20	o.	o.	NOUN
aji-34	360	21	signaling	signal	VERB
aji-34	360	22	by	by	ADP
aji-34	360	23	the	the	DET
aji-34	360	24	cytokine	cytokine	ADJ
aji-34	360	25	receptor	receptor	NOUN
aji-34	360	26	superfamily	superfamily	NOUN
aji-34	360	27	:	:	PUNCT
aji-34	361	1	jaks	jak	NOUN
aji-34	361	2	;	;	PUNCT
aji-34	361	3	1994	1994	NUM
aji-34	361	4	.	.	PUNCT
aji-34	362	1	shehu	shehu	PROPN
aji-34	362	2	et	et	PROPN
aji-34	362	3	al	al	PROPN
aji-34	362	4	.	.	PROPN
aji-34	362	5	;	;	PUNCT
aji-34	362	6	aji	aji	PROPN
aji-34	362	7	,	,	PUNCT
aji-34	362	8	3(1	3(1	NUM
aji-34	362	9	):	):	PUNCT
aji-34	362	10	259	259	NUM
aji-34	362	11	-	-	SYM
aji-34	362	12	268	268	NUM
aji-34	362	13	,	,	PUNCT
aji-34	362	14	2020	2020	NUM
aji-34	362	15	;	;	PUNCT
aji-34	362	16	article	article	NOUN
aji-34	362	17	no.aji.57314	no.aji.57314	PROPN
aji-34	362	18	267	267	NUM
aji-34	362	19	31	31	NUM
aji-34	362	20	.	.	PUNCT
aji-34	363	1	jones	jones	PROPN
aji-34	363	2	sa	sa	PROPN
aji-34	363	3	,	,	PUNCT
aji-34	363	4	richards	richards	PROPN
aji-34	363	5	pj	pj	PROPN
aji-34	363	6	,	,	PUNCT
aji-34	363	7	scheller	scheller	PROPN
aji-34	363	8	j	j	PROPN
aji-34	363	9	,	,	PUNCT
aji-34	363	10	rosejohn	rosejohn	PROPN
aji-34	363	11	s.	s.	PROPN
aji-34	363	12	il-6	il-6	NOUN
aji-34	363	13	transsignaling	transsignaling	PROPN
aji-34	363	14	:	:	PUNCT
aji-34	363	15	the	the	PRON
aji-34	363	16	in	in	ADP
aji-34	363	17	vivo	vivo	ADJ
aji-34	363	18	consequences	consequence	NOUN
aji-34	363	19	.	.	PUNCT
aji-34	364	1	journal	journal	NOUN
aji-34	364	2	of	of	ADP
aji-34	364	3	interferon	interferon	PROPN
aji-34	364	4	&	&	CCONJ
aji-34	364	5	cytokine	cytokine	PROPN
aji-34	364	6	research	research	NOUN
aji-34	364	7	.	.	PUNCT
aji-34	365	1	2005;25:241–253	2005;25:241–253	NUM
aji-34	365	2	.	.	NOUN
aji-34	366	1	32	32	NUM
aji-34	366	2	.	.	X
aji-34	367	1	firestein	firestein	PROPN
aji-34	367	2	gs	gs	PROPN
aji-34	367	3	.	.	PUNCT
aji-34	367	4	evolving	evolve	VERB
aji-34	367	5	concepts	concept	NOUN
aji-34	367	6	of	of	ADP
aji-34	367	7	rheumatoid	rheumatoid	NOUN
aji-34	367	8	arthritis	arthritis	NOUN
aji-34	367	9	.	.	PUNCT
aji-34	368	1	nature	nature	NOUN
aji-34	368	2	.	.	PUNCT
aji-34	369	1	2003;423	2003;423	NUM
aji-34	369	2	:	:	PUNCT
aji-34	369	3	356–361	356–361	NUM
aji-34	369	4	.	.	PUNCT
aji-34	370	1	33	33	NUM
aji-34	370	2	.	.	PUNCT
aji-34	371	1	aletaha	aletaha	PROPN
aji-34	371	2	d	d	PROPN
aji-34	371	3	,	,	PUNCT
aji-34	371	4	neogi	neogi	PROPN
aji-34	371	5	t	t	PROPN
aji-34	371	6	,	,	PUNCT
aji-34	371	7	silman	silman	PROPN
aji-34	371	8	aj	aj	PROPN
aji-34	371	9	,	,	PUNCT
aji-34	371	10	funovits	funovits	PROPN
aji-34	371	11	j	j	PROPN
aji-34	371	12	,	,	PUNCT
aji-34	371	13	felson	felson	NOUN
aji-34	371	14	dt	dt	PROPN
aji-34	371	15	,	,	PUNCT
aji-34	371	16	bingham	bingham	PROPN
aji-34	371	17	co	co	PROPN
aji-34	371	18	,	,	PUNCT
aji-34	371	19	iii	iii	PROPN
aji-34	371	20	,	,	PUNCT
aji-34	371	21	birnbaum	birnbaum	PROPN
aji-34	371	22	ns	ns	PROPN
aji-34	371	23	,	,	PUNCT
aji-34	371	24	burmester	burmester	NOUN
aji-34	371	25	gr	gr	NOUN
aji-34	371	26	,	,	PUNCT
aji-34	371	27	bykerk	bykerk	NOUN
aji-34	371	28	vp	vp	PROPN
aji-34	371	29	,	,	PUNCT
aji-34	371	30	cohen	cohen	PROPN
aji-34	371	31	md	md	PROPN
aji-34	371	32	,	,	PUNCT
aji-34	371	33	combe	combe	PROPN
aji-34	371	34	b	b	PROPN
aji-34	371	35	,	,	PUNCT
aji-34	371	36	costenbader	costenbader	PROPN
aji-34	371	37	kh	kh	PROPN
aji-34	371	38	,	,	PUNCT
aji-34	371	39	dougados	dougado	VERB
aji-34	371	40	m	m	PROPN
aji-34	371	41	,	,	PUNCT
aji-34	371	42	emery	emery	PROPN
aji-34	371	43	p	p	PROPN
aji-34	371	44	,	,	PUNCT
aji-34	371	45	ferraccioli	ferraccioli	NOUN
aji-34	371	46	g	g	NOUN
aji-34	371	47	,	,	PUNCT
aji-34	371	48	hazes	hazes	PROPN
aji-34	371	49	jm	jm	PROPN
aji-34	371	50	,	,	PUNCT
aji-34	371	51	hobbs	hobbs	PROPN
aji-34	371	52	k	k	PROPN
aji-34	371	53	,	,	PUNCT
aji-34	371	54	huizinga	huizinga	PROPN
aji-34	371	55	tw	tw	PROPN
aji-34	371	56	,	,	PUNCT
aji-34	371	57	kavanaugh	kavanaugh	PROPN
aji-34	371	58	a	a	PROPN
aji-34	371	59	,	,	PUNCT
aji-34	372	1	hawker	hawker	AUX
aji-34	372	2	g.	g.	PROPN
aji-34	372	3	2010	2010	NUM
aji-34	372	4	rheumatoid	rheumatoid	VERB
aji-34	372	5	arthritis	arthritis	NOUN
aji-34	372	6	classification	classification	NOUN
aji-34	372	7	criteria	criterion	NOUN
aji-34	372	8	:	:	PUNCT
aji-34	372	9	an	an	DET
aji-34	372	10	american	american	PROPN
aji-34	372	11	college	college	PROPN
aji-34	372	12	of	of	ADP
aji-34	372	13	rheumatology	rheumatology	PROPN
aji-34	372	14	/	/	SYM
aji-34	372	15	european	european	PROPN
aji-34	372	16	league	league	PROPN
aji-34	372	17	against	against	ADP
aji-34	372	18	rheumatism	rheumatism	NOUN
aji-34	372	19	collaborative	collaborative	ADJ
aji-34	372	20	initiative	initiative	NOUN
aji-34	372	21	.	.	PUNCT
aji-34	373	1	[	[	X
aji-34	373	2	erratum	erratum	NOUN
aji-34	373	3	,	,	PUNCT
aji-34	373	4	ann	ann	PROPN
aji-34	373	5	rheum	rheum	PROPN
aji-34	373	6	dis	dis	PROPN
aji-34	373	7	2010;69:1892	2010;69:1892	NUM
aji-34	373	8	.	.	PUNCT
aji-34	373	9	]	]	PUNCT
aji-34	373	10	.	.	PUNCT
aji-34	374	1	annals	annal	NOUN
aji-34	374	2	of	of	ADP
aji-34	374	3	the	the	DET
aji-34	374	4	rheumatic	rheumatic	ADJ
aji-34	374	5	diseases	disease	NOUN
aji-34	374	6	.	.	PUNCT
aji-34	375	1	2010	2010	NUM
aji-34	375	2	;	;	PUNCT
aji-34	375	3	69:1580–1588	69:1580–1588	NUM
aji-34	375	4	.	.	PUNCT
aji-34	376	1	34	34	NUM
aji-34	376	2	.	.	PUNCT
aji-34	377	1	lawrence	lawrence	PROPN
aji-34	377	2	rc	rc	PROPN
aji-34	377	3	,	,	PUNCT
aji-34	377	4	helmick	helmick	PROPN
aji-34	377	5	cg	cg	PROPN
aji-34	377	6	,	,	PUNCT
aji-34	377	7	arnett	arnett	PROPN
aji-34	377	8	fc	fc	PROPN
aji-34	377	9	,	,	PUNCT
aji-34	377	10	deyo	deyo	PROPN
aji-34	377	11	ra	ra	PROPN
aji-34	377	12	,	,	PUNCT
aji-34	377	13	felson	felson	NOUN
aji-34	377	14	dt	dt	PROPN
aji-34	377	15	,	,	PUNCT
aji-34	377	16	giannini	giannini	PROPN
aji-34	377	17	eh	eh	INTJ
aji-34	377	18	,	,	PUNCT
aji-34	377	19	heyse	heyse	PROPN
aji-34	377	20	sp	sp	PROPN
aji-34	377	21	,	,	PUNCT
aji-34	377	22	hirsch	hirsch	PROPN
aji-34	377	23	r	r	PROPN
aji-34	377	24	,	,	PUNCT
aji-34	377	25	hochberg	hochberg	PROPN
aji-34	377	26	mc	mc	PROPN
aji-34	377	27	,	,	PUNCT
aji-34	377	28	hunder	hunder	NOUN
aji-34	377	29	gg	gg	PROPN
aji-34	377	30	,	,	PUNCT
aji-34	377	31	liang	liang	PROPN
aji-34	377	32	mh	mh	PROPN
aji-34	377	33	,	,	PUNCT
aji-34	377	34	pillemer	pillemer	PROPN
aji-34	377	35	sr	sr	PROPN
aji-34	377	36	,	,	PUNCT
aji-34	377	37	steen	steen	PROPN
aji-34	377	38	vd	vd	PROPN
aji-34	377	39	,	,	PUNCT
aji-34	377	40	wolfe	wolfe	PROPN
aji-34	377	41	f.	f.	PROPN
aji-34	377	42	estimates	estimate	NOUN
aji-34	377	43	of	of	ADP
aji-34	377	44	the	the	DET
aji-34	377	45	prevalence	prevalence	NOUN
aji-34	377	46	of	of	ADP
aji-34	377	47	arthritis	arthritis	NOUN
aji-34	377	48	and	and	CCONJ
aji-34	377	49	selected	select	VERB
aji-34	377	50	musculoskeletal	musculoskeletal	ADJ
aji-34	377	51	disorders	disorder	NOUN
aji-34	377	52	in	in	ADP
aji-34	377	53	the	the	DET
aji-34	377	54	united	united	PROPN
aji-34	377	55	states	states	PROPN
aji-34	377	56	.	.	PUNCT
aji-34	378	1	arthritis	arthritis	NOUN
aji-34	378	2	and	and	CCONJ
aji-34	378	3	rheumatism	rheumatism	NOUN
aji-34	378	4	.	.	PUNCT
aji-34	379	1	1998;41:778–799	1998;41:778–799	NUM
aji-34	379	2	.	.	PROPN
aji-34	380	1	35	35	NUM
aji-34	380	2	.	.	PUNCT
aji-34	381	1	pincus	pincus	PROPN
aji-34	381	2	t	t	PROPN
aji-34	381	3	,	,	PUNCT
aji-34	381	4	callahan	callahan	PROPN
aji-34	381	5	lf	lf	PROPN
aji-34	381	6	.	.	PROPN
aji-34	381	7	reassessment	reassessment	NOUN
aji-34	381	8	of	of	ADP
aji-34	381	9	twelve	twelve	NUM
aji-34	381	10	traditional	traditional	ADJ
aji-34	381	11	paradigms	paradigm	NOUN
aji-34	381	12	concerning	concern	VERB
aji-34	381	13	the	the	DET
aji-34	381	14	diagnosis	diagnosis	NOUN
aji-34	381	15	,	,	PUNCT
aji-34	381	16	prevalence	prevalence	NOUN
aji-34	381	17	,	,	PUNCT
aji-34	381	18	morbidity	morbidity	NOUN
aji-34	381	19	and	and	CCONJ
aji-34	381	20	mortality	mortality	NOUN
aji-34	381	21	of	of	ADP
aji-34	381	22	rheumatoid	rheumatoid	NOUN
aji-34	381	23	arthritis	arthritis	NOUN
aji-34	381	24	.	.	PUNCT
aji-34	382	1	scandinavian	scandinavian	ADJ
aji-34	382	2	journal	journal	PROPN
aji-34	382	3	of	of	ADP
aji-34	382	4	rheumatology	rheumatology	NOUN
aji-34	382	5	.	.	PUNCT
aji-34	383	1	supplement	supplement	NOUN
aji-34	383	2	.	.	PUNCT
aji-34	384	1	1989;79:67–96	1989;79:67–96	NUM
aji-34	384	2	.	.	PUNCT
aji-34	385	1	36	36	NUM
aji-34	385	2	.	.	X
aji-34	385	3	lard	lard	NOUN
aji-34	385	4	lr	lr	PROPN
aji-34	385	5	,	,	PUNCT
aji-34	385	6	visser	visser	PROPN
aji-34	385	7	h	h	PROPN
aji-34	385	8	,	,	PUNCT
aji-34	385	9	speyer	speyer	PROPN
aji-34	385	10	i	i	PROPN
aji-34	385	11	,	,	PUNCT
aji-34	385	12	vander	vander	PROPN
aji-34	385	13	horstbruinsma	horstbruinsma	VERB
aji-34	385	14	ie	ie	X
aji-34	385	15	,	,	PUNCT
aji-34	385	16	zwinderman	zwinderman	NOUN
aji-34	385	17	ah	ah	INTJ
aji-34	385	18	,	,	PUNCT
aji-34	385	19	breedveld	breedveld	VERB
aji-34	385	20	fc	fc	PROPN
aji-34	385	21	,	,	PUNCT
aji-34	385	22	hazes	hazes	PROPN
aji-34	385	23	jm	jm	PROPN
aji-34	385	24	.	.	PROPN
aji-34	386	1	early	early	ADV
aji-34	386	2	versus	versus	ADP
aji-34	386	3	delayed	delayed	ADJ
aji-34	386	4	treatment	treatment	NOUN
aji-34	386	5	in	in	ADP
aji-34	386	6	patients	patient	NOUN
aji-34	386	7	with	with	ADP
aji-34	386	8	recent	recent	ADJ
aji-34	386	9	-	-	PUNCT
aji-34	386	10	onset	onset	NOUN
aji-34	386	11	rheumatoid	rheumatoid	NOUN
aji-34	386	12	arthritis	arthritis	NOUN
aji-34	386	13	:	:	PUNCT
aji-34	386	14	comparison	comparison	NOUN
aji-34	386	15	of	of	ADP
aji-34	386	16	two	two	NUM
aji-34	386	17	cohorts	cohort	NOUN
aji-34	386	18	who	who	PRON
aji-34	386	19	received	receive	VERB
aji-34	386	20	different	different	ADJ
aji-34	386	21	treatment	treatment	NOUN
aji-34	386	22	strategies	strategy	NOUN
aji-34	386	23	.	.	PUNCT
aji-34	387	1	the	the	DET
aji-34	387	2	american	american	PROPN
aji-34	387	3	journal	journal	PROPN
aji-34	387	4	of	of	ADP
aji-34	387	5	medicine	medicine	NOUN
aji-34	387	6	.	.	PUNCT
aji-34	388	1	2001;111:446–451	2001;111:446–451	X
aji-34	388	2	.	.	PUNCT
aji-34	389	1	37	37	NUM
aji-34	389	2	.	.	PUNCT
aji-34	390	1	rau	rau	PROPN
aji-34	390	2	r	r	PROPN
aji-34	390	3	,	,	PUNCT
aji-34	390	4	herborn	herborn	ADJ
aji-34	390	5	g	g	PROPN
aji-34	390	6	,	,	PUNCT
aji-34	390	7	menninger	menninger	PROPN
aji-34	390	8	h	h	PROPN
aji-34	390	9	,	,	PUNCT
aji-34	390	10	blechschmidt	blechschmidt	ADJ
aji-34	390	11	j.	j.	PROPN
aji-34	390	12	comparison	comparison	NOUN
aji-34	390	13	of	of	ADP
aji-34	390	14	intramuscular	intramuscular	ADJ
aji-34	390	15	methotrexate	methotrexate	NOUN
aji-34	390	16	and	and	CCONJ
aji-34	390	17	gold	gold	NOUN
aji-34	390	18	sodium	sodium	NOUN
aji-34	390	19	thiomalate	thiomalate	NOUN
aji-34	390	20	in	in	ADP
aji-34	390	21	the	the	DET
aji-34	390	22	treatment	treatment	NOUN
aji-34	390	23	of	of	ADP
aji-34	390	24	early	early	ADJ
aji-34	390	25	erosive	erosive	NOUN
aji-34	390	26	rheumatoid	rheumatoid	NOUN
aji-34	390	27	arthritis	arthritis	NOUN
aji-34	390	28	:	:	PUNCT
aji-34	390	29	12	12	NUM
aji-34	390	30	month	month	NOUN
aji-34	390	31	data	datum	NOUN
aji-34	390	32	of	of	ADP
aji-34	390	33	a	a	DET
aji-34	390	34	double	double	ADJ
aji-34	390	35	-	-	PUNCT
aji-34	390	36	blind	blind	ADJ
aji-34	390	37	parallel	parallel	ADJ
aji-34	390	38	study	study	NOUN
aji-34	390	39	of	of	ADP
aji-34	390	40	174	174	NUM
aji-34	390	41	patients	patient	NOUN
aji-34	390	42	.	.	PUNCT
aji-34	391	1	british	british	ADJ
aji-34	391	2	journal	journal	PROPN
aji-34	391	3	of	of	ADP
aji-34	391	4	rheumatology	rheumatology	NOUN
aji-34	391	5	.	.	PUNCT
aji-34	392	1	1997;36:345–352	1997;36:345–352	NUM
aji-34	392	2	.	.	PROPN
aji-34	393	1	38	38	NUM
aji-34	393	2	.	.	PUNCT
aji-34	394	1	saag	saag	PROPN
aji-34	394	2	kg	kg	PROPN
aji-34	394	3	,	,	PUNCT
aji-34	394	4	criswell	criswell	PROPN
aji-34	394	5	la	la	PROPN
aji-34	394	6	,	,	PUNCT
aji-34	394	7	sems	sem	NOUN
aji-34	394	8	km	km	PROPN
aji-34	394	9	,	,	PUNCT
aji-34	394	10	nettleman	nettleman	PROPN
aji-34	394	11	md	md	PROPN
aji-34	394	12	,	,	PUNCT
aji-34	394	13	kolluri	kolluri	PROPN
aji-34	394	14	s.	s.	PROPN
aji-34	394	15	low	low	PROPN
aji-34	394	16	-	-	PUNCT
aji-34	394	17	dose	dose	NOUN
aji-34	394	18	corticosteroids	corticosteroid	NOUN
aji-34	394	19	in	in	ADP
aji-34	394	20	rheumatoid	rheumatoid	NOUN
aji-34	394	21	arthritis	arthritis	NOUN
aji-34	394	22	.	.	PUNCT
aji-34	395	1	a	a	DET
aji-34	395	2	meta	meta	ADJ
aji-34	395	3	-	-	PUNCT
aji-34	395	4	analysis	analysis	NOUN
aji-34	395	5	of	of	ADP
aji-34	395	6	their	their	PRON
aji-34	395	7	moderate	moderate	ADJ
aji-34	395	8	-	-	PUNCT
aji-34	395	9	term	term	NOUN
aji-34	395	10	effectiveness	effectiveness	NOUN
aji-34	395	11	.	.	PUNCT
aji-34	396	1	arthritis	arthritis	NOUN
aji-34	396	2	and	and	CCONJ
aji-34	396	3	rheumatism	rheumatism	NOUN
aji-34	396	4	.	.	PUNCT
aji-34	397	1	1996;39:1818–1825	1996;39:1818–1825	NUM
aji-34	397	2	.	.	PUNCT
aji-34	398	1	39	39	NUM
aji-34	398	2	.	.	PUNCT
aji-34	399	1	arthritis	arthritis	NOUN
aji-34	399	2	by	by	ADP
aji-34	399	3	the	the	DET
aji-34	399	4	numbers	number	NOUN
aji-34	399	5	.	.	PUNCT
aji-34	400	1	arthritis	arthritis	PROPN
aji-34	400	2	foundation	foundation	PROPN
aji-34	400	3	.	.	PUNCT
aji-34	401	1	available	available	ADJ
aji-34	401	2	:	:	PUNCT
aji-34	401	3	https://www.arthritis.org	https://www.arthritis.org	ADJ
aji-34	401	4	/	/	SYM
aji-34	401	5	docume	docume	PROPN
aji-34	401	6	nts	nt	NOUN
aji-34	401	7	/	/	SYM
aji-34	401	8	sections	section	NOUN
aji-34	401	9	/	/	SYM
aji-34	401	10	about	about	ADP
aji-34	401	11	-	-	PUNCT
aji-34	401	12	arthritis	arthritis	NOUN
aji-34	401	13	/	/	SYM
aji-34	401	14	arthritis	arthritis	NOUN
aji-34	401	15	-	-	PUNCT
aji-34	401	16	factsstats	factsstat	NOUN
aji-34	401	17	-	-	PUNCT
aji-34	401	18	figures.pdf	figures.pdf	NOUN
aji-34	401	19	.	.	PUNCT
aji-34	402	1	(	(	PUNCT
aji-34	402	2	accessed	access	VERB
aji-34	402	3	may	may	PROPN
aji-34	402	4	28	28	NUM
aji-34	402	5	,	,	PUNCT
aji-34	402	6	2019	2019	NUM
aji-34	402	7	)	)	PUNCT
aji-34	402	8	40	40	NUM
aji-34	402	9	.	.	PUNCT
aji-34	403	1	conditions	condition	NOUN
aji-34	403	2	cr	cr	PROPN
aji-34	403	3	.	.	PUNCT
aji-34	403	4	world	world	PROPN
aji-34	403	5	health	health	PROPN
aji-34	403	6	organization	organization	PROPN
aji-34	403	7	.	.	PUNCT
aji-34	404	1	available	available	ADJ
aji-34	404	2	:	:	PUNCT
aji-34	404	3	https://www.who.int	https://www.who.int	NOUN
aji-34	404	4	/	/	SYM
aji-34	404	5	topics	topic	NOUN
aji-34	404	6	/	/	SYM
aji-34	404	7	rheum	rheum	NOUN
aji-34	404	8	atic	atic	ADJ
aji-34	404	9	/	/	SYM
aji-34	404	10	en/	en/	NOUN
aji-34	404	11	(	(	PUNCT
aji-34	404	12	accessed	access	VERB
aji-34	404	13	may	may	PROPN
aji-34	404	14	28	28	NUM
aji-34	404	15	,	,	PUNCT
aji-34	404	16	2019	2019	NUM
aji-34	404	17	)	)	PUNCT
aji-34	404	18	41	41	NUM
aji-34	404	19	.	.	PUNCT
aji-34	405	1	crowson	crowson	NOUN
aji-34	405	2	cs	cs	PROPN
aji-34	405	3	.	.	PROPN
aji-34	405	4	epidemiology	epidemiology	PROPN
aji-34	405	5	of	of	ADP
aji-34	405	6	,	,	PUNCT
aji-34	405	7	risk	risk	NOUN
aji-34	405	8	factors	factor	NOUN
aji-34	405	9	for	for	ADP
aji-34	405	10	,	,	PUNCT
aji-34	405	11	and	and	CCONJ
aji-34	405	12	possible	possible	ADJ
aji-34	405	13	causes	cause	NOUN
aji-34	405	14	of	of	ADP
aji-34	405	15	rheumatoid	rheumatoid	NOUN
aji-34	405	16	arthritis	arthritis	NOUN
aji-34	405	17	.	.	PUNCT
aji-34	406	1	up	up	ADP
aji-34	406	2	to	to	ADP
aji-34	406	3	date	date	NOUN
aji-34	406	4	.	.	PUNCT
aji-34	407	1	available	available	ADJ
aji-34	407	2	:	:	PUNCT
aji-34	407	3	https://www.uptodate.com	https://www.uptodate.com	PROPN
aji-34	407	4	/	/	SYM
aji-34	407	5	conten	conten	PROPN
aji-34	407	6	ts	ts	NOUN
aji-34	407	7	/	/	SYM
aji-34	407	8	epidemiology	epidemiology	NOUN
aji-34	407	9	-	-	PUNCT
aji-34	407	10	of	of	ADP
aji-34	407	11	-	-	PUNCT
aji-34	407	12	risk	risk	NOUN
aji-34	407	13	-	-	PUNCT
aji-34	407	14	factors	factor	NOUN
aji-34	407	15	-	-	PUNCT
aji-34	407	16	for	for	ADP
aji-34	407	17	-	-	PUNCT
aji-34	407	18	andpossible	andpossible	ADJ
aji-34	407	19	-	-	PUNCT
aji-34	407	20	causes	cause	NOUN
aji-34	407	21	-	-	PUNCT
aji-34	407	22	of	of	ADP
aji-34	407	23	-	-	PUNCT
aji-34	407	24	rheumatoid	rheumatoid	NOUN
aji-34	407	25	-	-	PUNCT
aji-34	407	26	arthritis	arthritis	NOUN
aji-34	407	27	.	.	PUNCT
aji-34	408	1	(	(	PUNCT
aji-34	408	2	accessed	access	VERB
aji-34	408	3	may	may	PROPN
aji-34	408	4	28	28	NUM
aji-34	408	5	,	,	PUNCT
aji-34	408	6	2019	2019	NUM
aji-34	408	7	)	)	PUNCT
aji-34	408	8	42	42	NUM
aji-34	408	9	.	.	PUNCT
aji-34	409	1	miossec	miossec	PROPN
aji-34	409	2	p.	p.	NOUN
aji-34	409	3	an	an	DET
aji-34	409	4	update	update	NOUN
aji-34	409	5	on	on	ADP
aji-34	409	6	the	the	DET
aji-34	409	7	cytokine	cytokine	ADJ
aji-34	409	8	network	network	NOUN
aji-34	409	9	in	in	ADP
aji-34	409	10	rheumatoid	rheumatoid	NOUN
aji-34	409	11	arthritis	arthritis	NOUN
aji-34	409	12	.	.	PUNCT
aji-34	410	1	current	current	ADJ
aji-34	410	2	opinion	opinion	NOUN
aji-34	410	3	in	in	ADP
aji-34	410	4	rheumatology	rheumatology	NOUN
aji-34	410	5	.	.	PUNCT
aji-34	411	1	2004;16:218	2004;16:218	ADJ
aji-34	411	2	–	–	PUNCT
aji-34	411	3	222	222	NUM
aji-34	411	4	.	.	PUNCT
aji-34	412	1	43	43	NUM
aji-34	412	2	.	.	PUNCT
aji-34	413	1	choy	choy	NOUN
aji-34	413	2	eh	eh	INTJ
aji-34	413	3	,	,	PUNCT
aji-34	413	4	panayi	panayi	NOUN
aji-34	413	5	gs	gs	AUX
aji-34	413	6	.	.	PUNCT
aji-34	413	7	cytokine	cytokine	VERB
aji-34	413	8	pathways	pathway	NOUN
aji-34	413	9	and	and	CCONJ
aji-34	413	10	joint	joint	ADJ
aji-34	413	11	inflammation	inflammation	NOUN
aji-34	413	12	in	in	ADP
aji-34	413	13	rheumatoid	rheumatoid	NOUN
aji-34	413	14	arthritis	arthritis	NOUN
aji-34	413	15	.	.	PUNCT
aji-34	414	1	the	the	DET
aji-34	414	2	new	new	PROPN
aji-34	414	3	england	england	PROPN
aji-34	414	4	journal	journal	PROPN
aji-34	414	5	of	of	ADP
aji-34	414	6	medicine	medicine	NOUN
aji-34	414	7	.	.	PUNCT
aji-34	415	1	2001;344:907–916	2001;344:907–916	NUM
aji-34	415	2	.	.	PUNCT
aji-34	416	1	44	44	NUM
aji-34	416	2	.	.	PUNCT
aji-34	417	1	van	van	PROPN
aji-34	417	2	der	der	PROPN
aji-34	417	3	heijde	heijde	NOUN
aji-34	417	4	dm	dm	PROPN
aji-34	417	5	.	.	PUNCT
aji-34	418	1	joint	joint	ADJ
aji-34	418	2	erosions	erosion	NOUN
aji-34	418	3	and	and	CCONJ
aji-34	418	4	patients	patient	NOUN
aji-34	418	5	with	with	ADP
aji-34	418	6	early	early	ADJ
aji-34	418	7	rheumatoid	rheumatoid	NOUN
aji-34	418	8	arthritis	arthritis	NOUN
aji-34	418	9	.	.	PUNCT
aji-34	419	1	british	british	ADJ
aji-34	419	2	journal	journal	PROPN
aji-34	419	3	of	of	ADP
aji-34	419	4	rheumatology	rheumatology	NOUN
aji-34	419	5	.	.	PUNCT
aji-34	420	1	1995;34(suppl	1995;34(suppl	PROPN
aji-34	421	1	2):74–78	2):74–78	NUM
aji-34	421	2	.	.	PUNCT
aji-34	422	1	45	45	NUM
aji-34	422	2	.	.	PUNCT
aji-34	423	1	tateiwa	tateiwa	PROPN
aji-34	423	2	d	d	PROPN
aji-34	423	3	,	,	PUNCT
aji-34	423	4	yoshikawa	yoshikawa	PROPN
aji-34	423	5	h	h	PROPN
aji-34	423	6	,	,	PUNCT
aji-34	423	7	kaito	kaito	PROPN
aji-34	423	8	t.	t.	PROPN
aji-34	423	9	cartilage	cartilage	PROPN
aji-34	423	10	and	and	CCONJ
aji-34	423	11	bone	bone	NOUN
aji-34	423	12	destruction	destruction	NOUN
aji-34	423	13	in	in	ADP
aji-34	423	14	arthritis	arthritis	NOUN
aji-34	423	15	:	:	PUNCT
aji-34	423	16	pathogenesis	pathogenesis	NOUN
aji-34	423	17	and	and	CCONJ
aji-34	423	18	treatment	treatment	NOUN
aji-34	423	19	strategy	strategy	NOUN
aji-34	423	20	:	:	PUNCT
aji-34	423	21	a	a	DET
aji-34	423	22	literature	literature	NOUN
aji-34	423	23	review	review	NOUN
aji-34	423	24	.	.	PUNCT
aji-34	424	1	cells	cell	NOUN
aji-34	424	2	.	.	PUNCT
aji-34	425	1	2019;8:818	2019;8:818	X
aji-34	425	2	.	.	PUNCT
aji-34	426	1	46	46	NUM
aji-34	426	2	.	.	PUNCT
aji-34	427	1	tilders	tilders	PROPN
aji-34	427	2	fj	fj	PROPN
aji-34	427	3	,	,	PUNCT
aji-34	427	4	derijk	derijk	PROPN
aji-34	427	5	rh	rh	PROPN
aji-34	427	6	,	,	PUNCT
aji-34	427	7	van	van	PROPN
aji-34	427	8	dam	dam	PROPN
aji-34	427	9	am	am	PROPN
aji-34	427	10	,	,	PUNCT
aji-34	427	11	vincent	vincent	PROPN
aji-34	427	12	va	va	PROPN
aji-34	427	13	,	,	PUNCT
aji-34	427	14	schotanus	schotanus	X
aji-34	427	15	k	k	NOUN
aji-34	427	16	,	,	PUNCT
aji-34	427	17	persoons	persoons	PROPN
aji-34	427	18	jh	jh	PROPN
aji-34	427	19	.	.	PUNCT
aji-34	428	1	activation	activation	NOUN
aji-34	428	2	of	of	ADP
aji-34	428	3	the	the	DET
aji-34	428	4	hypothalamus	hypothalamus	NOUN
aji-34	428	5	-	-	PUNCT
aji-34	428	6	pituitaryadrenal	pituitaryadrenal	ADJ
aji-34	428	7	axis	axis	NOUN
aji-34	428	8	by	by	ADP
aji-34	428	9	bacterial	bacterial	ADJ
aji-34	428	10	endotoxins	endotoxin	NOUN
aji-34	428	11	:	:	PUNCT
aji-34	428	12	routes	route	NOUN
aji-34	428	13	and	and	CCONJ
aji-34	428	14	intermediate	intermediate	ADJ
aji-34	428	15	signals	signal	NOUN
aji-34	428	16	.	.	PUNCT
aji-34	429	1	psychoneuroendocrinology	psychoneuroendocrinology	NOUN
aji-34	429	2	.	.	PUNCT
aji-34	430	1	1994;19:209	1994;19:209	NUM
aji-34	430	2	–	–	PUNCT
aji-34	430	3	232	232	NUM
aji-34	430	4	.	.	PUNCT
aji-34	431	1	47	47	NUM
aji-34	431	2	.	.	PUNCT
aji-34	432	1	nawroth	nawroth	PROPN
aji-34	432	2	pp	pp	PROPN
aji-34	432	3	,	,	PUNCT
aji-34	432	4	bank	bank	PROPN
aji-34	432	5	i	i	PROPN
aji-34	432	6	,	,	PUNCT
aji-34	432	7	handley	handley	PROPN
aji-34	432	8	d	d	PROPN
aji-34	432	9	,	,	PUNCT
aji-34	432	10	cassimeris	cassimeris	PROPN
aji-34	432	11	j	j	PROPN
aji-34	432	12	,	,	PUNCT
aji-34	432	13	chess	chess	NOUN
aji-34	432	14	l	l	NOUN
aji-34	432	15	,	,	PUNCT
aji-34	432	16	stern	stern	PROPN
aji-34	432	17	d.	d.	PROPN
aji-34	432	18	tumor	tumor	PROPN
aji-34	432	19	necrosis	necrosis	NOUN
aji-34	432	20	factor	factor	NOUN
aji-34	432	21	/	/	SYM
aji-34	432	22	cachectin	cachectin	NOUN
aji-34	432	23	interacts	interact	VERB
aji-34	432	24	with	with	ADP
aji-34	432	25	endothelial	endothelial	ADJ
aji-34	432	26	cell	cell	NOUN
aji-34	432	27	receptors	receptor	NOUN
aji-34	432	28	to	to	PART
aji-34	432	29	induce	induce	VERB
aji-34	432	30	release	release	NOUN
aji-34	432	31	of	of	ADP
aji-34	432	32	interleukin	interleukin	NOUN
aji-34	432	33	1	1	NUM
aji-34	432	34	.	.	PUNCT
aji-34	433	1	the	the	DET
aji-34	433	2	journal	journal	NOUN
aji-34	433	3	of	of	ADP
aji-34	433	4	experimental	experimental	ADJ
aji-34	433	5	medicine	medicine	NOUN
aji-34	433	6	.	.	PUNCT
aji-34	434	1	1986;163:1363	1986;163:1363	NUM
aji-34	434	2	–	–	PUNCT
aji-34	434	3	1375	1375	NUM
aji-34	434	4	.	.	PUNCT
aji-34	435	1	48	48	NUM
aji-34	435	2	.	.	PUNCT
aji-34	436	1	haworth	haworth	PROPN
aji-34	436	2	c	c	PROPN
aji-34	436	3	,	,	PUNCT
aji-34	436	4	brennan	brennan	PROPN
aji-34	436	5	fm	fm	PROPN
aji-34	436	6	,	,	PUNCT
aji-34	436	7	chantry	chantry	NOUN
aji-34	436	8	d	d	PROPN
aji-34	436	9	,	,	PUNCT
aji-34	436	10	turner	turner	PROPN
aji-34	436	11	m	m	PROPN
aji-34	436	12	,	,	PUNCT
aji-34	436	13	maini	maini	PROPN
aji-34	436	14	rn	rn	PROPN
aji-34	436	15	,	,	PUNCT
aji-34	436	16	feldmann	feldmann	NOUN
aji-34	436	17	m.	m.	NOUN
aji-34	436	18	expression	expression	NOUN
aji-34	436	19	of	of	ADP
aji-34	436	20	granulocyte	granulocyte	ADJ
aji-34	436	21	-	-	PUNCT
aji-34	436	22	macrophage	macrophage	ADJ
aji-34	436	23	colony	colony	NOUN
aji-34	436	24	-	-	PUNCT
aji-34	436	25	stimulating	stimulate	VERB
aji-34	436	26	factor	factor	NOUN
aji-34	436	27	in	in	ADP
aji-34	436	28	rheumatoid	rheumatoid	NOUN
aji-34	436	29	arthritis	arthritis	NOUN
aji-34	436	30	:	:	PUNCT
aji-34	436	31	regulation	regulation	NOUN
aji-34	436	32	by	by	ADP
aji-34	436	33	tumor	tumor	NOUN
aji-34	436	34	necrosis	necrosis	NOUN
aji-34	436	35	factor	factor	NOUN
aji-34	436	36	-	-	PUNCT
aji-34	436	37	alpha	alpha	NOUN
aji-34	436	38	.	.	PUNCT
aji-34	437	1	european	european	PROPN
aji-34	437	2	journal	journal	PROPN
aji-34	437	3	of	of	ADP
aji-34	437	4	immunology	immunology	NOUN
aji-34	437	5	.	.	PUNCT
aji-34	438	1	1991;21:2575–2579	1991;21:2575–2579	NUM
aji-34	438	2	.	.	PUNCT
aji-34	439	1	49	49	NUM
aji-34	439	2	.	.	PUNCT
aji-34	440	1	keffer	keffer	PROPN
aji-34	440	2	j	j	PROPN
aji-34	440	3	,	,	PUNCT
aji-34	440	4	probert	probert	PROPN
aji-34	440	5	l	l	PROPN
aji-34	440	6	,	,	PUNCT
aji-34	440	7	cazlaris	cazlaris	PROPN
aji-34	440	8	h	h	NOUN
aji-34	440	9	,	,	PUNCT
aji-34	440	10	georgopoulos	georgopoulos	PROPN
aji-34	440	11	s	s	PROPN
aji-34	440	12	,	,	PUNCT
aji-34	440	13	kaslaris	kaslaris	PROPN
aji-34	440	14	e	e	NOUN
aji-34	440	15	,	,	PUNCT
aji-34	440	16	kioussis	kioussis	PROPN
aji-34	440	17	d	d	PROPN
aji-34	440	18	,	,	PUNCT
aji-34	440	19	kollias	kollias	PROPN
aji-34	440	20	g.	g.	PROPN
aji-34	440	21	transgenic	transgenic	NOUN
aji-34	440	22	mice	mouse	NOUN
aji-34	440	23	expressing	express	VERB
aji-34	440	24	https://www.arthritis.org/documents/sections/about-arthritis/arthritis-facts-stats-figures.pdf	https://www.arthritis.org/documents/sections/about-arthritis/arthritis-facts-stats-figures.pdf	NOUN
aji-34	440	25	https://www.arthritis.org/documents/sections/about-arthritis/arthritis-facts-stats-figures.pdf	https://www.arthritis.org/documents/sections/about-arthritis/arthritis-facts-stats-figures.pdf	NOUN
aji-34	440	26	https://www.arthritis.org/documents/sections/about-arthritis/arthritis-facts-stats-figures.pdf	https://www.arthritis.org/documents/sections/about-arthritis/arthritis-facts-stats-figures.pdf	NOUN
aji-34	440	27	https://www.who.int/topics/rheumatic/en/	https://www.who.int/topics/rheumatic/en/	NOUN
aji-34	440	28	https://www.who.int/topics/rheumatic/en/	https://www.who.int/topics/rheumatic/en/	NOUN
aji-34	440	29	https://www.uptodate.com/contents/epidemiology-of-risk-factors-for-and-possible-causes-of-rheumatoid-arthritis	https://www.uptodate.com/contents/epidemiology-of-risk-factors-for-and-possible-causes-of-rheumatoid-arthritis	NOUN
aji-34	440	30	https://www.uptodate.com/contents/epidemiology-of-risk-factors-for-and-possible-causes-of-rheumatoid-arthritis	https://www.uptodate.com/contents/epidemiology-of-risk-factors-for-and-possible-causes-of-rheumatoid-arthritis	NOUN
aji-34	440	31	https://www.uptodate.com/contents/epidemiology-of-risk-factors-for-and-possible-causes-of-rheumatoid-arthritis	https://www.uptodate.com/contents/epidemiology-of-risk-factors-for-and-possible-causes-of-rheumatoid-arthritis	NOUN
aji-34	440	32	shehu	shehu	NOUN
aji-34	440	33	et	et	PROPN
aji-34	440	34	al	al	PROPN
aji-34	440	35	.	.	PROPN
aji-34	440	36	;	;	PUNCT
aji-34	440	37	aji	aji	PROPN
aji-34	440	38	,	,	PUNCT
aji-34	440	39	3(1	3(1	NUM
aji-34	440	40	):	):	PUNCT
aji-34	440	41	259	259	NUM
aji-34	440	42	-	-	SYM
aji-34	440	43	268	268	NUM
aji-34	440	44	,	,	PUNCT
aji-34	440	45	2020	2020	NUM
aji-34	440	46	;	;	PUNCT
aji-34	440	47	article	article	NOUN
aji-34	440	48	no.aji.57314	no.aji.57314	PROPN
aji-34	440	49	268	268	NUM
aji-34	440	50	human	human	ADJ
aji-34	440	51	tumour	tumour	NOUN
aji-34	440	52	necrosis	necrosis	NOUN
aji-34	440	53	factor	factor	NOUN
aji-34	440	54	:	:	PUNCT
aji-34	440	55	a	a	DET
aji-34	440	56	predictive	predictive	ADJ
aji-34	440	57	genetic	genetic	ADJ
aji-34	440	58	model	model	NOUN
aji-34	440	59	of	of	ADP
aji-34	440	60	arthritis	arthritis	NOUN
aji-34	440	61	.	.	PUNCT
aji-34	441	1	the	the	DET
aji-34	441	2	embo	embo	PROPN
aji-34	441	3	journal	journal	PROPN
aji-34	441	4	.	.	PUNCT
aji-34	442	1	1991;10:4025–4031	1991;10:4025–4031	NUM
aji-34	442	2	.	.	PUNCT
aji-34	443	1	50	50	NUM
aji-34	443	2	.	.	PUNCT
aji-34	444	1	mcinnes	mcinne	NOUN
aji-34	444	2	ib	ib	PROPN
aji-34	444	3	,	,	PUNCT
aji-34	444	4	schett	schett	PROPN
aji-34	444	5	g.	g.	PROPN
aji-34	444	6	the	the	DET
aji-34	444	7	pathogenesis	pathogenesis	NOUN
aji-34	444	8	of	of	ADP
aji-34	444	9	rheumatoid	rheumatoid	NOUN
aji-34	444	10	arthritis	arthritis	NOUN
aji-34	444	11	.	.	PUNCT
aji-34	445	1	the	the	DET
aji-34	445	2	new	new	PROPN
aji-34	445	3	england	england	PROPN
aji-34	445	4	journal	journal	PROPN
aji-34	445	5	of	of	ADP
aji-34	445	6	medicine	medicine	NOUN
aji-34	445	7	.	.	PUNCT
aji-34	446	1	2011;365:2205–2219	2011;365:2205–2219	NUM
aji-34	446	2	.	.	PUNCT
aji-34	447	1	51	51	NUM
aji-34	447	2	.	.	PUNCT
aji-34	447	3	bresnihan	bresnihan	PROPN
aji-34	447	4	b	b	PROPN
aji-34	447	5	,	,	PUNCT
aji-34	447	6	alvaro	alvaro	PROPN
aji-34	447	7	-	-	PUNCT
aji-34	447	8	gracia	gracia	PROPN
aji-34	447	9	jm	jm	PROPN
aji-34	447	10	,	,	PUNCT
aji-34	447	11	cobby	cobby	PROPN
aji-34	447	12	m	m	PROPN
aji-34	447	13	,	,	PUNCT
aji-34	447	14	doherty	doherty	PROPN
aji-34	447	15	m	m	PROPN
aji-34	447	16	,	,	PUNCT
aji-34	447	17	domljan	domljan	VERB
aji-34	447	18	z	z	PROPN
aji-34	447	19	,	,	PUNCT
aji-34	447	20	emery	emery	PROPN
aji-34	447	21	p	p	PROPN
aji-34	447	22	,	,	PUNCT
aji-34	447	23	nuki	nuki	PROPN
aji-34	447	24	g	g	PROPN
aji-34	447	25	,	,	PUNCT
aji-34	447	26	pavelka	pavelka	PROPN
aji-34	447	27	k	k	PROPN
aji-34	447	28	,	,	PUNCT
aji-34	447	29	rau	rau	PROPN
aji-34	447	30	r	r	PROPN
aji-34	447	31	,	,	PUNCT
aji-34	447	32	rozman	rozman	NOUN
aji-34	447	33	b	b	PROPN
aji-34	447	34	,	,	PUNCT
aji-34	447	35	watt	watt	NOUN
aji-34	447	36	i	i	PROPN
aji-34	447	37	,	,	PUNCT
aji-34	447	38	williams	williams	PROPN
aji-34	447	39	b	b	PROPN
aji-34	447	40	,	,	PUNCT
aji-34	447	41	aitchison	aitchison	PROPN
aji-34	447	42	r	r	PROPN
aji-34	447	43	,	,	PUNCT
aji-34	447	44	mccabe	mccabe	PROPN
aji-34	447	45	d	d	PROPN
aji-34	447	46	,	,	PUNCT
aji-34	447	47	musikic	musikic	ADJ
aji-34	447	48	p.	p.	NOUN
aji-34	447	49	treatment	treatment	NOUN
aji-34	447	50	of	of	ADP
aji-34	447	51	rheumatoid	rheumatoid	NOUN
aji-34	447	52	arthritis	arthritis	NOUN
aji-34	447	53	with	with	ADP
aji-34	447	54	recombinant	recombinant	ADJ
aji-34	447	55	human	human	ADJ
aji-34	447	56	interleukin-1	interleukin-1	NOUN
aji-34	447	57	receptor	receptor	NOUN
aji-34	447	58	antagonist	antagonist	NOUN
aji-34	447	59	.	.	PUNCT
aji-34	448	1	arthritis	arthritis	NOUN
aji-34	448	2	and	and	CCONJ
aji-34	448	3	rheumatism	rheumatism	NOUN
aji-34	448	4	.	.	PUNCT
aji-34	449	1	1998;41:2196–2204	1998;41:2196–2204	NUM
aji-34	449	2	.	.	PUNCT
aji-34	450	1	52	52	NUM
aji-34	450	2	.	.	PUNCT
aji-34	451	1	smith	smith	PROPN
aji-34	451	2	rj	rj	PROPN
aji-34	451	3	,	,	PUNCT
aji-34	451	4	chin	chin	PROPN
aji-34	451	5	je	je	PROPN
aji-34	451	6	,	,	PUNCT
aji-34	451	7	sam	sam	PROPN
aji-34	451	8	lm	lm	PROPN
aji-34	451	9	,	,	PUNCT
aji-34	451	10	justen	justen	VERB
aji-34	451	11	jm	jm	PROPN
aji-34	451	12	.	.	PROPN
aji-34	451	13	biologic	biologic	NOUN
aji-34	451	14	effects	effect	NOUN
aji-34	451	15	of	of	ADP
aji-34	451	16	an	an	DET
aji-34	451	17	interleukin-1	interleukin-1	NOUN
aji-34	451	18	receptor	receptor	NOUN
aji-34	451	19	antagonist	antagonist	NOUN
aji-34	451	20	protein	protein	NOUN
aji-34	451	21	on	on	ADP
aji-34	451	22	interleukin-1stimulated	interleukin-1stimulate	VERB
aji-34	451	23	cartilage	cartilage	NOUN
aji-34	451	24	erosion	erosion	NOUN
aji-34	451	25	and	and	CCONJ
aji-34	451	26	chondrocyte	chondrocyte	NOUN
aji-34	451	27	responsiveness	responsiveness	NOUN
aji-34	451	28	.	.	PUNCT
aji-34	452	1	arthritis	arthritis	NOUN
aji-34	452	2	and	and	CCONJ
aji-34	452	3	rheumatism	rheumatism	NOUN
aji-34	452	4	.	.	PUNCT
aji-34	453	1	1991;34:78–83	1991;34:78–83	X
aji-34	453	2	.	.	X
aji-34	454	1	53	53	NUM
aji-34	454	2	.	.	PUNCT
aji-34	455	1	seckinger	seckinger	NOUN
aji-34	455	2	p	p	PROPN
aji-34	455	3	,	,	PUNCT
aji-34	455	4	klein	klein	PROPN
aji-34	455	5	-	-	PUNCT
aji-34	455	6	nulend	nulend	PROPN
aji-34	455	7	j	j	PROPN
aji-34	455	8	,	,	PUNCT
aji-34	455	9	alander	alander	NOUN
aji-34	455	10	c	c	PROPN
aji-34	455	11	,	,	PUNCT
aji-34	455	12	thompson	thompson	PROPN
aji-34	455	13	rc	rc	PROPN
aji-34	455	14	,	,	PUNCT
aji-34	455	15	dayer	dayer	PROPN
aji-34	455	16	jm	jm	PROPN
aji-34	455	17	,	,	PUNCT
aji-34	455	18	raisz	raisz	ADJ
aji-34	455	19	lg	lg	PROPN
aji-34	455	20	.	.	PROPN
aji-34	455	21	natural	natural	ADJ
aji-34	455	22	and	and	CCONJ
aji-34	455	23	recombinant	recombinant	ADJ
aji-34	455	24	human	human	ADJ
aji-34	455	25	il-1	il-1	ADP
aji-34	455	26	receptor	receptor	NOUN
aji-34	455	27	antagonists	antagonist	NOUN
aji-34	455	28	block	block	VERB
aji-34	455	29	the	the	DET
aji-34	455	30	effects	effect	NOUN
aji-34	455	31	of	of	ADP
aji-34	455	32	il1	il1	PRON
aji-34	455	33	on	on	ADP
aji-34	455	34	bone	bone	NOUN
aji-34	455	35	resorption	resorption	NOUN
aji-34	455	36	and	and	CCONJ
aji-34	455	37	prostaglandin	prostaglandin	NOUN
aji-34	455	38	production	production	NOUN
aji-34	455	39	.	.	PUNCT
aji-34	456	1	international	international	ADJ
aji-34	456	2	immunology	immunology	NOUN
aji-34	456	3	.	.	PUNCT
aji-34	457	1	1990;145:4181–4184	1990;145:4181–4184	VERB
aji-34	457	2	.	.	PUNCT
aji-34	458	1	54	54	NUM
aji-34	458	2	.	.	X
aji-34	458	3	firestein	firestein	PROPN
aji-34	458	4	gs	gs	PROPN
aji-34	458	5	,	,	PUNCT
aji-34	458	6	boyle	boyle	PROPN
aji-34	458	7	dl	dl	PROPN
aji-34	458	8	,	,	PUNCT
aji-34	458	9	yu	yu	PROPN
aji-34	458	10	c	c	AUX
aji-34	458	11	,	,	PUNCT
aji-34	458	12	paine	paine	PROPN
aji-34	458	13	mm	mm	PROPN
aji-34	458	14	,	,	PUNCT
aji-34	458	15	whisen	whisen	VERB
aji-34	458	16	td	td	PROPN
aji-34	458	17	,	,	PUNCT
aji-34	458	18	zvaifler	zvaifler	PROPN
aji-34	458	19	nj	nj	PROPN
aji-34	458	20	,	,	PUNCT
aji-34	458	21	arend	arend	VERB
aji-34	458	22	wp	wp	PROPN
aji-34	458	23	.	.	PROPN
aji-34	459	1	synovial	synovial	ADJ
aji-34	459	2	interleukin-1	interleukin-1	NUM
aji-34	459	3	receptor	receptor	NOUN
aji-34	459	4	antagonist	antagonist	NOUN
aji-34	459	5	and	and	CCONJ
aji-34	459	6	interleukin-1	interleukin-1	NUM
aji-34	459	7	balance	balance	NOUN
aji-34	459	8	in	in	ADP
aji-34	459	9	rheumatoid	rheumatoid	NOUN
aji-34	459	10	arthritis	arthritis	NOUN
aji-34	459	11	.	.	PUNCT
aji-34	460	1	arthritis	arthritis	NOUN
aji-34	460	2	and	and	CCONJ
aji-34	460	3	rheumatism	rheumatism	NOUN
aji-34	460	4	.	.	PUNCT
aji-34	461	1	1994;37:644–652	1994;37:644–652	PROPN
aji-34	461	2	.	.	PUNCT
aji-34	462	1	55	55	NUM
aji-34	462	2	.	.	PUNCT
aji-34	463	1	horai	horai	VERB
aji-34	463	2	r	r	PROPN
aji-34	463	3	,	,	PUNCT
aji-34	463	4	saijo	saijo	PROPN
aji-34	463	5	s	s	PROPN
aji-34	463	6	,	,	PUNCT
aji-34	463	7	tanioka	tanioka	NOUN
aji-34	463	8	h	h	NOUN
aji-34	463	9	,	,	PUNCT
aji-34	463	10	nakae	nakae	PROPN
aji-34	463	11	s	s	PROPN
aji-34	463	12	,	,	PUNCT
aji-34	463	13	sudo	sudo	X
aji-34	463	14	k	k	NOUN
aji-34	463	15	,	,	PUNCT
aji-34	463	16	okahara	okahara	NOUN
aji-34	463	17	a	a	PRON
aji-34	463	18	,	,	PUNCT
aji-34	463	19	ikuse	ikuse	PROPN
aji-34	463	20	t	t	PROPN
aji-34	463	21	,	,	PUNCT
aji-34	463	22	asano	asano	PROPN
aji-34	463	23	m	m	PROPN
aji-34	463	24	,	,	PUNCT
aji-34	463	25	iwakura	iwakura	PROPN
aji-34	463	26	y.	y.	PROPN
aji-34	463	27	development	development	PROPN
aji-34	463	28	of	of	ADP
aji-34	463	29	chronic	chronic	ADJ
aji-34	463	30	inflammatory	inflammatory	ADJ
aji-34	463	31	arthropathy	arthropathy	ADJ
aji-34	463	32	resembling	resemble	VERB
aji-34	463	33	rheumatoid	rheumatoid	NOUN
aji-34	463	34	arthritis	arthritis	NOUN
aji-34	463	35	in	in	ADP
aji-34	463	36	interleukin	interleukin	NOUN
aji-34	463	37	1	1	NUM
aji-34	463	38	receptor	receptor	NOUN
aji-34	463	39	antagonist	antagonist	NOUN
aji-34	463	40	-	-	PUNCT
aji-34	463	41	deficient	deficient	ADJ
aji-34	463	42	mice	mouse	NOUN
aji-34	463	43	.	.	PUNCT
aji-34	464	1	the	the	DET
aji-34	464	2	journal	journal	NOUN
aji-34	464	3	of	of	ADP
aji-34	464	4	experimental	experimental	ADJ
aji-34	464	5	medicine	medicine	NOUN
aji-34	464	6	.	.	PUNCT
aji-34	465	1	2000	2000	NUM
aji-34	465	2	;	;	PUNCT
aji-34	465	3	191:313–320	191:313–320	NUM
aji-34	465	4	.	.	PUNCT
aji-34	466	1	56	56	NUM
aji-34	466	2	.	.	PUNCT
aji-34	466	3	yang	yang	PROPN
aji-34	466	4	bb	bb	PROPN
aji-34	466	5	,	,	PUNCT
aji-34	466	6	baughman	baughman	NOUN
aji-34	466	7	s	s	PROPN
aji-34	466	8	,	,	PUNCT
aji-34	466	9	sullivan	sullivan	PROPN
aji-34	466	10	jt	jt	PROPN
aji-34	466	11	.	.	PUNCT
aji-34	467	1	pharmacokinetics	pharmacokinetic	NOUN
aji-34	467	2	of	of	ADP
aji-34	467	3	anakinra	anakinra	NOUN
aji-34	467	4	in	in	ADP
aji-34	467	5	subjects	subject	NOUN
aji-34	467	6	with	with	ADP
aji-34	467	7	different	different	ADJ
aji-34	467	8	levels	level	NOUN
aji-34	467	9	of	of	ADP
aji-34	467	10	renal	renal	ADJ
aji-34	467	11	function	function	NOUN
aji-34	467	12	.	.	PUNCT
aji-34	468	1	clinical	clinical	ADJ
aji-34	468	2	pharmacology	pharmacology	NOUN
aji-34	468	3	and	and	CCONJ
aji-34	468	4	therapeutics	therapeutic	NOUN
aji-34	468	5	.	.	PUNCT
aji-34	469	1	2003;74:85–94	2003;74:85–94	NUM
aji-34	469	2	.	.	X
aji-34	470	1	57	57	NUM
aji-34	470	2	.	.	PUNCT
aji-34	471	1	palomo	palomo	PROPN
aji-34	471	2	j	j	PROPN
aji-34	471	3	,	,	PUNCT
aji-34	471	4	dietrich	dietrich	PROPN
aji-34	471	5	d	d	PROPN
aji-34	471	6	,	,	PUNCT
aji-34	471	7	martin	martin	PROPN
aji-34	471	8	p	p	X
aji-34	471	9	,	,	PUNCT
aji-34	471	10	palmer	palmer	PROPN
aji-34	471	11	g	g	NOUN
aji-34	471	12	,	,	PUNCT
aji-34	471	13	gabay	gabay	PROPN
aji-34	471	14	c.	c.	NOUN
aji-34	471	15	the	the	DET
aji-34	471	16	interleukin	interleukin	NOUN
aji-34	471	17	(	(	PUNCT
aji-34	471	18	il)-1	il)-1	ADP
aji-34	471	19	cytokine	cytokine	ADJ
aji-34	471	20	family	family	NOUN
aji-34	471	21	–	–	PUNCT
aji-34	471	22	balance	balance	NOUN
aji-34	471	23	between	between	ADP
aji-34	471	24	agonists	agonist	NOUN
aji-34	471	25	and	and	CCONJ
aji-34	471	26	antagonists	antagonist	NOUN
aji-34	471	27	in	in	ADP
aji-34	471	28	inflammatory	inflammatory	ADJ
aji-34	471	29	diseases	disease	NOUN
aji-34	471	30	,	,	PUNCT
aji-34	471	31	cytokine	cytokine	NOUN
aji-34	471	32	.	.	PUNCT
aji-34	472	1	2015;76(1):25	2015;76(1):25	X
aji-34	472	2	-	-	SYM
aji-34	472	3	37	37	NUM
aji-34	472	4	.	.	PUNCT
aji-34	473	1	[	[	X
aji-34	473	2	issn	issn	NOUN
aji-34	473	3	:	:	PUNCT
aji-34	473	4	1043	1043	NUM
aji-34	473	5	-	-	SYM
aji-34	473	6	4666	4666	NUM
aji-34	473	7	]	]	PUNCT
aji-34	474	1	58	58	NUM
aji-34	474	2	.	.	PUNCT
aji-34	475	1	kishimoto	kishimoto	PROPN
aji-34	475	2	t.	t.	PROPN
aji-34	475	3	interleukin-6	interleukin-6	PROPN
aji-34	475	4	:	:	PUNCT
aji-34	475	5	from	from	ADP
aji-34	475	6	basic	basic	ADJ
aji-34	475	7	science	science	NOUN
aji-34	475	8	to	to	ADP
aji-34	475	9	medicine—40	medicine—40	NOUN
aji-34	475	10	years	year	NOUN
aji-34	475	11	in	in	ADP
aji-34	475	12	immunology	immunology	NOUN
aji-34	475	13	.	.	PUNCT
aji-34	476	1	annual	annual	ADJ
aji-34	476	2	review	review	NOUN
aji-34	476	3	of	of	ADP
aji-34	476	4	immunology	immunology	NOUN
aji-34	476	5	.	.	PUNCT
aji-34	477	1	2005;23:1–21	2005;23:1–21	NUM
aji-34	477	2	.	.	PUNCT
aji-34	478	1	59	59	NUM
aji-34	478	2	.	.	PUNCT
aji-34	479	1	emery	emery	PROPN
aji-34	479	2	p	p	PROPN
aji-34	479	3	,	,	PUNCT
aji-34	479	4	keystone	keystone	PROPN
aji-34	479	5	e	e	NOUN
aji-34	479	6	,	,	PUNCT
aji-34	479	7	tony	tony	PROPN
aji-34	479	8	hp	hp	PROPN
aji-34	479	9	,	,	PUNCT
aji-34	479	10	cantagrel	cantagrel	NOUN
aji-34	479	11	a	a	PRON
aji-34	479	12	,	,	PUNCT
aji-34	479	13	van	van	PROPN
aji-34	479	14	vollenhoven	vollenhoven	NOUN
aji-34	479	15	r	r	PROPN
aji-34	479	16	,	,	PUNCT
aji-34	479	17	sanchez	sanchez	PROPN
aji-34	479	18	a	a	NOUN
aji-34	479	19	,	,	PUNCT
aji-34	479	20	alecock	alecock	PROPN
aji-34	479	21	e	e	PROPN
aji-34	479	22	,	,	PUNCT
aji-34	479	23	lee	lee	PROPN
aji-34	479	24	j	j	PROPN
aji-34	479	25	,	,	PUNCT
aji-34	479	26	kremer	kremer	PROPN
aji-34	479	27	j.	j.	PROPN
aji-34	479	28	il-6	il-6	PROPN
aji-34	479	29	receptor	receptor	NOUN
aji-34	479	30	inhibition	inhibition	NOUN
aji-34	479	31	with	with	ADP
aji-34	479	32	tocilizumab	tocilizumab	NOUN
aji-34	479	33	improves	improve	VERB
aji-34	479	34	treatment	treatment	NOUN
aji-34	479	35	outcomes	outcome	NOUN
aji-34	479	36	in	in	ADP
aji-34	479	37	patients	patient	NOUN
aji-34	479	38	with	with	ADP
aji-34	479	39	rheumatoid	rheumatoid	NOUN
aji-34	479	40	arthritis	arthritis	NOUN
aji-34	479	41	refractory	refractory	NOUN
aji-34	479	42	to	to	ADP
aji-34	479	43	anti	anti	ADJ
aji-34	479	44	-	-	ADJ
aji-34	479	45	tumour	tumour	ADJ
aji-34	479	46	necrosis	necrosis	NOUN
aji-34	479	47	factor	factor	NOUN
aji-34	479	48	biologicals	biological	NOUN
aji-34	479	49	:	:	PUNCT
aji-34	479	50	results	result	NOUN
aji-34	479	51	from	from	ADP
aji-34	479	52	a	a	DET
aji-34	479	53	24	24	NUM
aji-34	479	54	-	-	PUNCT
aji-34	479	55	week	week	NOUN
aji-34	479	56	multicentre	multicentre	NOUN
aji-34	479	57	randomized	randomize	VERB
aji-34	479	58	placebocontrolled	placebocontrolle	VERB
aji-34	479	59	trial	trial	NOUN
aji-34	479	60	.	.	PUNCT
aji-34	480	1	annals	annal	NOUN
aji-34	480	2	of	of	ADP
aji-34	480	3	the	the	DET
aji-34	480	4	rheumatic	rheumatic	ADJ
aji-34	480	5	diseases	disease	NOUN
aji-34	480	6	.	.	PUNCT
aji-34	481	1	2008;67:1516	2008;67:1516	NUM
aji-34	481	2	–	–	PUNCT
aji-34	481	3	1523	1523	NUM
aji-34	481	4	.	.	PUNCT
aji-34	482	1	60	60	NUM
aji-34	482	2	.	.	PUNCT
aji-34	483	1	frey	frey	PROPN
aji-34	483	2	n	n	CCONJ
aji-34	483	3	,	,	PUNCT
aji-34	483	4	grange	grange	PROPN
aji-34	483	5	s	s	PROPN
aji-34	483	6	,	,	PUNCT
aji-34	483	7	woodworth	woodworth	ADJ
aji-34	483	8	t.	t.	NOUN
aji-34	483	9	population	population	NOUN
aji-34	483	10	pharmacokinetic	pharmacokinetic	ADJ
aji-34	483	11	analysis	analysis	NOUN
aji-34	483	12	of	of	ADP
aji-34	483	13	tocilizumab	tocilizumab	NOUN
aji-34	483	14	in	in	ADP
aji-34	483	15	patients	patient	NOUN
aji-34	483	16	with	with	ADP
aji-34	483	17	rheumatoid	rheumatoid	NOUN
aji-34	483	18	arthritis	arthritis	NOUN
aji-34	483	19	.	.	PUNCT
aji-34	484	1	journal	journal	NOUN
aji-34	484	2	of	of	ADP
aji-34	484	3	clinical	clinical	ADJ
aji-34	484	4	pharmacology	pharmacology	NOUN
aji-34	484	5	.	.	PUNCT
aji-34	485	1	2010;50:754–766	2010;50:754–766	NOUN
aji-34	485	2	.	.	NOUN
aji-34	485	3	61	61	NUM
aji-34	485	4	.	.	PUNCT
aji-34	486	1	sato	sato	PROPN
aji-34	486	2	k	k	PROPN
aji-34	486	3	,	,	PUNCT
aji-34	486	4	tsuchiya	tsuchiya	PROPN
aji-34	486	5	m	m	PROPN
aji-34	486	6	,	,	PUNCT
aji-34	486	7	saldanha	saldanha	PROPN
aji-34	486	8	j	j	PROPN
aji-34	486	9	,	,	PUNCT
aji-34	486	10	koishihara	koishihara	PROPN
aji-34	486	11	y	y	PROPN
aji-34	486	12	,	,	PUNCT
aji-34	486	13	ohsugi	ohsugi	PROPN
aji-34	486	14	y	y	PROPN
aji-34	486	15	,	,	PUNCT
aji-34	486	16	kishimoto	kishimoto	PROPN
aji-34	486	17	t	t	PROPN
aji-34	486	18	,	,	PUNCT
aji-34	486	19	bendig	bendig	PROPN
aji-34	486	20	mm	mm	PROPN
aji-34	486	21	.	.	PUNCT
aji-34	486	22	reshaping	reshape	VERB
aji-34	486	23	a	a	DET
aji-34	486	24	human	human	ADJ
aji-34	486	25	antibody	antibody	NOUN
aji-34	486	26	to	to	PART
aji-34	486	27	inhibit	inhibit	VERB
aji-34	486	28	the	the	DET
aji-34	486	29	interleukin	interleukin	NOUN
aji-34	486	30	6	6	NUM
aji-34	486	31	-	-	PUNCT
aji-34	486	32	dependent	dependent	ADJ
aji-34	486	33	tumor	tumor	NOUN
aji-34	486	34	cell	cell	NOUN
aji-34	486	35	growth	growth	NOUN
aji-34	486	36	.	.	PUNCT
aji-34	487	1	cancer	cancer	NOUN
aji-34	487	2	research	research	NOUN
aji-34	487	3	.	.	PUNCT
aji-34	488	1	1993;53(4	1993;53(4	NUM
aji-34	488	2	):	):	PUNCT
aji-34	488	3	851–856	851–856	NUM
aji-34	488	4	.	.	PUNCT
aji-34	489	1	62	62	NUM
aji-34	489	2	.	.	PUNCT
aji-34	490	1	jones	jones	PROPN
aji-34	490	2	g	g	PROPN
aji-34	490	3	,	,	PUNCT
aji-34	490	4	darian	darian	PROPN
aji-34	490	5	-	-	PUNCT
aji-34	490	6	smith	smith	PROPN
aji-34	490	7	e	e	PROPN
aji-34	490	8	,	,	PUNCT
aji-34	490	9	kwok	kwok	PROPN
aji-34	490	10	m	m	PROPN
aji-34	490	11	,	,	PUNCT
aji-34	490	12	winzenberg	winzenberg	SCONJ
aji-34	490	13	t.	t.	ADJ
aji-34	490	14	effect	effect	NOUN
aji-34	490	15	of	of	ADP
aji-34	490	16	biologic	biologic	NOUN
aji-34	490	17	therapy	therapy	NOUN
aji-34	490	18	on	on	ADP
aji-34	490	19	radiological	radiological	ADJ
aji-34	490	20	progression	progression	NOUN
aji-34	490	21	in	in	ADP
aji-34	490	22	rheumatoid	rheumatoid	NOUN
aji-34	490	23	arthritis	arthritis	NOUN
aji-34	490	24	:	:	PUNCT
aji-34	490	25	what	what	PRON
aji-34	490	26	does	do	AUX
aji-34	490	27	it	it	PRON
aji-34	490	28	add	add	VERB
aji-34	490	29	to	to	PART
aji-34	490	30	methotrexate	methotrexate	VERB
aji-34	490	31	?	?	PUNCT
aji-34	491	1	biologics	biologic	NOUN
aji-34	491	2	.	.	PUNCT
aji-34	492	1	2012;6:155–161	2012;6:155–161	NUM
aji-34	492	2	.	.	PUNCT
aji-34	493	1	63	63	NUM
aji-34	493	2	.	.	PUNCT
aji-34	494	1	alten	alten	VERB
aji-34	494	2	r.	r.	PROPN
aji-34	494	3	tocilizumab	tocilizumab	PROPN
aji-34	494	4	:	:	PUNCT
aji-34	494	5	a	a	DET
aji-34	494	6	novel	novel	NOUN
aji-34	494	7	humanized	humanize	VERB
aji-34	494	8	anti	anti	ADJ
aji-34	494	9	-	-	ADJ
aji-34	494	10	interleukin	interleukin	ADJ
aji-34	494	11	6	6	NUM
aji-34	494	12	receptor	receptor	NOUN
aji-34	494	13	antibody	antibody	NOUN
aji-34	494	14	for	for	ADP
aji-34	494	15	the	the	DET
aji-34	494	16	treatment	treatment	NOUN
aji-34	494	17	of	of	ADP
aji-34	494	18	patients	patient	NOUN
aji-34	494	19	with	with	ADP
aji-34	494	20	rheumatoid	rheumatoid	NOUN
aji-34	494	21	arthritis	arthritis	NOUN
aji-34	494	22	.	.	PUNCT
aji-34	495	1	therapeutic	therapeutic	ADJ
aji-34	495	2	advances	advance	NOUN
aji-34	495	3	in	in	ADP
aji-34	495	4	musculoskeletal	musculoskeletal	ADJ
aji-34	495	5	disease	disease	NOUN
aji-34	495	6	.	.	PUNCT
aji-34	496	1	2011;3(3):133	2011;3(3):133	NUM
aji-34	496	2	–	–	PUNCT
aji-34	496	3	149	149	NUM
aji-34	496	4	.	.	PUNCT
aji-34	497	1	_	_	PUNCT
aji-34	498	1	_	_	PUNCT
aji-34	499	1	_	_	PUNCT
aji-34	500	1	_	_	PUNCT
aji-34	501	1	_	_	PUNCT
aji-34	502	1	_	_	PUNCT
aji-34	503	1	_	_	PUNCT
aji-34	504	1	_	_	PUNCT
aji-34	505	1	_	_	PUNCT
aji-34	506	1	_	_	PUNCT
aji-34	507	1	_	_	PUNCT
aji-34	508	1	_	_	PUNCT
aji-34	509	1	_	_	PUNCT
aji-34	510	1	_	_	PUNCT
aji-34	511	1	_	_	PUNCT
aji-34	512	1	_	_	PUNCT
aji-34	513	1	_	_	PUNCT
aji-34	514	1	_	_	PUNCT
aji-34	515	1	_	_	PUNCT
aji-34	516	1	_	_	PUNCT
aji-34	517	1	_	_	PUNCT
aji-34	518	1	_	_	PUNCT
aji-34	519	1	_	_	PUNCT
aji-34	520	1	_	_	PUNCT
aji-34	521	1	_	_	PUNCT
aji-34	522	1	_	_	PUNCT
aji-34	523	1	_	_	PUNCT
aji-34	524	1	_	_	PUNCT
aji-34	525	1	_	_	PUNCT
aji-34	526	1	_	_	PUNCT
aji-34	527	1	_	_	PUNCT
aji-34	528	1	_	_	PUNCT
aji-34	529	1	_	_	PUNCT
aji-34	530	1	_	_	PUNCT
aji-34	531	1	_	_	PUNCT
aji-34	532	1	_	_	PUNCT
aji-34	533	1	_	_	PUNCT
aji-34	534	1	_	_	PUNCT
aji-34	535	1	_	_	PUNCT
aji-34	536	1	_	_	PUNCT
aji-34	537	1	_	_	PUNCT
aji-34	538	1	_	_	PUNCT
aji-34	539	1	_	_	PUNCT
aji-34	540	1	_	_	PUNCT
aji-34	541	1	_	_	PUNCT
aji-34	542	1	_	_	PUNCT
aji-34	543	1	_	_	PUNCT
aji-34	544	1	_	_	PUNCT
aji-34	545	1	_	_	PUNCT
aji-34	546	1	_	_	PUNCT
aji-34	547	1	_	_	PUNCT
aji-34	548	1	_	_	PUNCT
aji-34	549	1	_	_	PUNCT
aji-34	550	1	_	_	PUNCT
aji-34	551	1	_	_	PUNCT
aji-34	552	1	_	_	PUNCT
aji-34	553	1	_	_	PUNCT
aji-34	554	1	_	_	PUNCT
aji-34	555	1	_	_	PUNCT
aji-34	556	1	_	_	PUNCT
aji-34	557	1	_	_	PUNCT
aji-34	558	1	_	_	PUNCT
aji-34	559	1	_	_	PUNCT
aji-34	560	1	_	_	PUNCT
aji-34	561	1	_	_	PUNCT
aji-34	562	1	_	_	PUNCT
aji-34	563	1	_	_	PUNCT
aji-34	564	1	_	_	PUNCT
aji-34	565	1	_	_	PUNCT
aji-34	566	1	_	_	PUNCT
aji-34	567	1	_	_	PUNCT
aji-34	568	1	_	_	PUNCT
aji-34	569	1	_	_	PUNCT
aji-34	570	1	_	_	PUNCT
aji-34	571	1	_	_	PUNCT
aji-34	572	1	_	_	PUNCT
aji-34	573	1	_	_	PUNCT
aji-34	574	1	_	_	PUNCT
aji-34	575	1	_	_	PUNCT
aji-34	576	1	_	_	PUNCT
aji-34	577	1	_	_	PUNCT
aji-34	578	1	©	©	ADP
aji-34	578	2	2020	2020	NUM
aji-34	578	3	shehu	shehu	NOUN
aji-34	578	4	et	et	PROPN
aji-34	578	5	al	al	PROPN
aji-34	578	6	.	.	PROPN
aji-34	578	7	;	;	PUNCT
aji-34	578	8	this	this	PRON
aji-34	578	9	is	be	AUX
aji-34	578	10	an	an	DET
aji-34	578	11	open	open	ADJ
aji-34	578	12	access	access	NOUN
aji-34	578	13	article	article	NOUN
aji-34	578	14	distributed	distribute	VERB
aji-34	578	15	under	under	ADP
aji-34	578	16	the	the	DET
aji-34	578	17	terms	term	NOUN
aji-34	578	18	of	of	ADP
aji-34	578	19	the	the	DET
aji-34	578	20	creative	creative	ADJ
aji-34	578	21	commons	common	NOUN
aji-34	578	22	attribution	attribution	NOUN
aji-34	578	23	license	license	NOUN
aji-34	578	24	(	(	PUNCT
aji-34	578	25	http://creativecommons.org/licenses/by/4.0	http://creativecommons.org/licenses/by/4.0	NOUN
aji-34	578	26	)	)	PUNCT
aji-34	578	27	,	,	PUNCT
aji-34	578	28	which	which	PRON
aji-34	578	29	permits	permit	VERB
aji-34	578	30	unrestricted	unrestricted	ADJ
aji-34	578	31	use	use	NOUN
aji-34	578	32	,	,	PUNCT
aji-34	578	33	distribution	distribution	NOUN
aji-34	578	34	,	,	PUNCT
aji-34	578	35	and	and	CCONJ
aji-34	578	36	reproduction	reproduction	NOUN
aji-34	578	37	in	in	ADP
aji-34	578	38	any	any	DET
aji-34	578	39	medium	medium	NOUN
aji-34	578	40	,	,	PUNCT
aji-34	578	41	provided	provide	VERB
aji-34	578	42	the	the	DET
aji-34	578	43	original	original	ADJ
aji-34	578	44	work	work	NOUN
aji-34	578	45	is	be	AUX
aji-34	578	46	properly	properly	ADV
aji-34	578	47	cited	cite	VERB
aji-34	578	48	.	.	PUNCT
aji-34	579	1	peer	peer	NOUN
aji-34	579	2	-	-	PUNCT
aji-34	579	3	review	review	NOUN
aji-34	579	4	history	history	NOUN
aji-34	579	5	:	:	PUNCT
aji-34	579	6	the	the	DET
aji-34	579	7	peer	peer	NOUN
aji-34	579	8	review	review	NOUN
aji-34	579	9	history	history	NOUN
aji-34	579	10	for	for	ADP
aji-34	579	11	this	this	DET
aji-34	579	12	paper	paper	NOUN
aji-34	579	13	can	can	AUX
aji-34	579	14	be	be	AUX
aji-34	579	15	accessed	access	VERB
aji-34	579	16	here	here	ADV
aji-34	579	17	:	:	PUNCT
aji-34	579	18	http://www.sdiarticle4.com/review-history/57314	http://www.sdiarticle4.com/review-history/57314	PROPN
aji-34	579	19	http://creativecommons.org/licenses/by/4.0	http://creativecommons.org/licenses/by/4.0	X