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ETHICS IN STEM CELL RESEARCH 

Md. Fakruddin 

Scientific Officer, Industrial Microbiology Laboratory,  

Institute of Food Science and Technology (IFST),  

Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka.  

Email: fakruddinmurad@gmail.com 

 

ABSTRACT: Stem cells have constituted a revolution in regenerative medicine and cancer therapies by 

providing the possibility of generating multiple therapeutically useful cell types that could be used for 

treating some of genetic and degenerative disorders. However, human embryonic stem cell research 

raises few ethical and political controversies because of its involvement in destruction of human embryos. 

The ethical issues in human embryonic stem cell research encompasses not only with question of the 

ethics of destroying human embryos, but also with questions about complicity of researchers in 

destruction of embryos, moral distinction between creating embryos for research purposes and creating 

them for reproductive ends and the permissibility of cloning human embryos to harvest stem cells. 

Bangladesh should formulate its own regulations justifying its stand regarding this matter. 

 

Key words: Stem cells, Applications, Prospects, Ethics. 

INTRODUCTION: Few technologies spark as much interest, hope and controversy as stem cell 

technology. Many people have strong opinions about the morality of stem cell research, but few have a 

strong understanding of the science and its potential. The excitement about stem cell research and its 

potential therapeutic applications is clearly evidenced by the large investments into research that have 

been made by corporations, governments and universities around the globe. Tempering the exuberance, 

however, are the myriad ethical, legal, and political challenges that face this field of research. The 

eventual resolution of these conflicts will determine the success of the research and potentially the face of 

medicine in the future
1
. 

What is stem cell? Stem cells are unspecialized cells with remarkable potentiality to develop into many 

different cell types. They are capable of renewing themselves through cell division
2
. Under special 

condition they can be induced to become tissue or specific cell with defined function, these distinguishing 

features make stem cell different from other types of cell. Stem Cells are undifferentiated cells that 

through replication have the capability of both self-renewal and differentiation into mature specialized 

cells
3,4

. 

Properties of stem cell: Stem cells have some unique properties compared to normal cells. First, they 

have longevity. They divide and replicate under laboratory conditions for long periods of time without 

differentiating until induced to do so. Second, they have plasticity. They are able to differentiate into 

different types of specialized cells, such as cardiac muscle or pancreatic cells
5,6

. 

History of stem cell research: Since their discovery in the early 1900s, stem cells have captured the 

imagination of scientists. Interest intensified, however in 1998, when Professor James Thomson at the 

University of Wisconsin isolated and grew stem cells derived from human embryos7. Soon thereafter, 

researcher from Johns Hopkins University achieved similar results with human germ stem cells
8
. These 

advances impelled a wave of stem cell research around the world, focusing on three areas: human 

development, birth defects and therapeutics. 



Bangladesh Journal of Bioethics 2012; 3(1):13-18 

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ETHICAL ISSUE OF STEM CELL RESEARCH: Ethical challenges are not new to medicine and medical 

research. Stem cell research raises the concern that humans are "playing god". This concern is 

particularly relevant when discussing the cloning of human embryos for research purposes. There is also 

the possibility of inadvertent germ-line (reproductive cells) manipulation, even with the use of adult stem 

cells. Germ-line manipulation would result in the genetic modification of the offspring and would have a 

permanent impact on the human species
9,10

. 

As therapies are developed and commercialized, society will have to consider the ethical implications of 

not only science but also the management of the corporations that bring such treatments to market
11,12

.   

The source of tissues used to obtain stem cells in one of the most incendiary topics surrounding stem cell 

research. The president's council of Bioethics suggested three primary and recurring points of contention 

with regard to the issue of tissue sources: the moral status of human embryos, complicity and the 

"alternative of adult stem cells"
13,14

. 

Stem cell research is controversial not because of its goals, but rather because of the means of obtaining 

some of the cells. The crux of the debate centers around embryonic stem cells, which enable research 

that may facilitate the development of medical treatments and cures, but which require the destruction of 

an embryo to derive. In addition, because cloning is one method of producing embryos for research, the 

ethical issues surrounding cloning are also relevant15,16. 

 

Table-I. Ethical issues at different phases of stem cell research17 

Phase of research Ethical issues 

Donation of biological materials Informed and voluntary consent 

Research with hESCs  

 

Destruction of embryos Creation of embryos specifically 

for research purposes 

1. Payment to oocyte donors 

2. Medical risks of oocyte retrieval 

3. Protecting reproductive interests of women in 

infertility treatment 

Use of stem cell lines derived at another 

institution 

Conflicting legal and ethical standards 

 

Stem cell clinical trials Risks and benefits of experimental intervention 

Informed consent 

 

A discussion of ethics in stem cell research cannot however be limited to the research arena. As 

therapies will be developed and commercialized, society will have to consider the ethical implications of 

not only the science but also the management of the corporations that brings such treatments to 

market
18,19

. Several of these issues are discussed in more detail in the following. 

Tissue source: The source of tissue used to obtain stem cells is one the most incendiary topics 

surrounding stem cell research. Three primary and recurring points of contention with regard to the issue 

of tissue sources are- the moral status of human embryos, complicity and the “alternative of adult stem 

cells”
13,20

.  

Moral status refers to the inherent worth of something from a moral standpoint (rather than economic, 

technical or other standpoint)
21

. The key question is, when does an embryo become a human? Some 

argues that to destroy a fetus in the course of research is simply to take the life of an innocent human 



Bangladesh Journal of Bioethics 2012; 3(1):13-18 

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individual. This unambiguous assertion holds that all embryonic stem cell research is morally wrong, 

regardless of potential benefit
22

.  Some other argues that becoming human requires more than the 

potential to develop into a human child. Following this logic, it is morally acceptable to destroy surplus or 

cloned embryos for the greater benefit of society
23

. Complicity relates to the question of who is 

responsible for embryo destruction. The third point of contention is “the alternative of adult stem cells”. 

Some contend that therapies derived from adult stem cells are not sufficient to advance research and 

innovations24,25. Hence research using stem cells from all sources including embryo should go forward. 

Legal issues: A report issued by the NIH in 2000 stated that “congressional prohibition does not prohibit 

the funding of research utilizing human pluripotent stem cells because they are not embryos”26. However, 

the report also stated that appropriations law (P.L. 105-277, section 511,112 STAT, 2681-386) prohibits 

funds “for the creation of a human embryo or embryos for research purposes, or research in which human 

embryos are destroyed, discarded or knowingly subjected to risk of injury or death”
27,28

. The problem, of 

course, is that human embryonic stem cells are derived from early embryos. The proposed NIH answer is 

to permit funding for pluripotent stem cell research while denying funding for deriving stem cells from 

embryos29,30. According to them, fund can be used “only if the cells were derived from early human 

embryos that were created for the purposes of infertility treatment and were in excess of clinical need of 

the individuals seeking such treatment”31,32.  

Worldwide Regulation Scenario: Policies on stem cell research vary greatly from nation to nation. 

Britain is leading the drive for acceptance of stem cell research. In early 2001, the U.K. parliament 

approved the amendment of the 1990 Human Fertilization and Embryology Act governing research on 

human embryos, which allows the use of embryos up to fourteen days old for research on the derivation 

and potential of human stem cells. In Israel, a national bioethics committee in 2001 approved the 

derivation of embryonic stem cells and research into therapeutic cloning. The bioethics committees of 

Australia, Canada and Japan have also allowed stem cell research. In Germany, parliament voted in 

January 2002 to allow research on imported human embryonic stem cell lines that had been created 

before January 20, 2002. These cell lines can only be used for research projects approved by regulatory 

body. But, in China, research on embryonic tissue is generally banned, according to the Chinese Health 

Ministry. However, the study of stem cells drawn from the umbilical cord and afterbirth is permitted33-35. 

Bangladesh Scenario: No such research using stem cells have been known to be performed in 

Bangladesh so far, though in-vitro fertilization and storage of germ cells is not new here. Government and 

policy makers still are not aware of this matter, hence no government regulation and policy on the 

acceptability and use of stem cell in research is yet to be formulated. Strict but rational regulations should 

be prepared and be in place for prospective stem cell research in this country to preserve ethical and 

moral values of the country people and to prevent unethical, unauthorized and unscientific use of stem 

cells in future. A national Bioethics committee should be formed to guide the government in this issue. 

Bangladesh being a Muslim country, it will be difficult to gain acceptability of this type of research from 

common people. Considering all the facts, government should make its stand clear with appropriate logic 

in this ground. Today or tomorrow, the wave of stem cell research will reach Bangladesh due to its 

immense commercial potential. So, we should be prepared well ahead of the time. 

CONCLUSION: Stem cell research has the potential to lead to the development of novel cellular and 

gene therapies that could be translated into effective and safe clinical treatments of numerous genetic 

and degenerative disorders in humans. Although stem cells are highly unlikely to contribute to human 

fantasies of immortality and eternal youth, tremendous progress has been made in the past few years in 

the potential use of these cells as therapeutic agents, which may lead to prolonged life with less suffering 

and higher quality.  In order to safely use stem cells or their differentiated progeny, methods of purification 



Bangladesh Journal of Bioethics 2012; 3(1):13-18 

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and methods of cell-death control will need to be developed. Another important aspect of stem-cell-based 

therapies will be the necessity of preventing the rejection of the donated cells by the immune system. In 

summary, much basic research lies ahead before application of a stem cell therapy to patients in a 

rigorous therapeutic manner is realized. However, mankind will surely benefit enormously by conducting 

research in this important area. 

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