id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bjp-15622	Channabasava, .; Govindappa, Melappa	First report of anticancer agent, lapachol producing endophyte, Aspergillus niger of Tabebuia argentea and its in vitro cytotoxicity assays	2014	12	.pdf	application/pdf	4939	272	56	The 3rd fraction of A. niger lapachol strongly inhibited the Allium cepa root actively growing cells at various stages of cell cycle in antimitotic assay and the index was 22.5 mg/mL, the yeast cells were died due to toxicity and possessed the cell necrosis and they exhibited the DNA fragmentation. We have found that A. niger lapachol is induced mitotic activity at various levels of cell cycle viz., shrinked interphase cells, abnormal chromosomal distribution after metaphase, chromosomal bridges with vagrant chromosomes at anaphase, chromosomal stickiness and clumping in telophase, chromosomal bridge and clumping, chromosomal degeneration, large nucleolus, binucleolar and nucleolar burst and mega cell and chromosomal clumping in small cells was observed was compared with normal mitotic phases of interphase, metaphase and anaphase (Figure 7 and 8).	cache/bjp-15622.pdf	txt/bjp-15622.txt