id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bjp-22865	Li, Yong-Ji; Zhang, Ting; Tu, Jian-Xin; Li, Gang; Zhou, Yan	Tangeretin inhibits IL-1β induced proliferation of rheumatoid synovial fibroblasts and the production of COX-2, PGE2 and MMPs via modulation of p38 MAPK/ERK/JNK pathways	2015	12	.pdf	application/pdf	5898	302	47	These results indicate that tange- Figure 4: Influence of tangeretin on IL-1 -induced protein expressions Tangeretin significantly reduced the IL-1 -induced raised expressions of MMPs and COX-2 following 24 hours (A and C) and 48 hours (B and D) of exposure. IL-1 -induced marked increases in the phosphorylation status and as well increased expressions of MAPK pathway proteins were regulat- ed by tangeretin at both the doses (50 and 100 µM) and at 24 hours (E and G) and 48 hours (F and H); L1-control; L2-IL-1 ; L3-tangeretin 50 µM; L4- tangeretin 100 µM; L5-IL-1 + tangeretin 50 µM; L6-IL-1 + tangeretin 100 µM; Values are represented as mean ± SD; n=3; *represents statistical significance at p<0.05 compared against control as determined by one-way ANOVA A B C Bangladesh J Pharmacol 2015; 10: 714-725 719 Figure 4: Influence of tangeretin on IL-1 -induced protein expressions (Cont.)	cache/bjp-22865.pdf	txt/bjp-22865.txt