id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bjp-23565	Qian, Yu-Xian; Yu, Rui; Qin, Shi-Rong	Paclitaxel and trastuzumab treatment affects insulin growth factor I expression in breast cancer cell lines	2015	9	.pdf	application/pdf	4073	204	59	Bangladesh Journal of Pharmacology Research Article Paclitaxel and trastuzumab treatment affects insulin growth factor I expres- sion in breast cancer cell lines BJP Introduction Insulin-like growth factor I receptor (IGF-1R) is a recep- tor tyrosine kinase (RTK) protein overexpressed (about 70%) in breast cancer cells (Nielson et al., 2004; Sachdev et al., 2004). 800 Bangladesh J Pharmacol 2015; 10: 799-806 Results Down-regulation of IGF-1Rb, IRS-2, PI3K and up- regulation of IGFBP-3 and PTEN by drug treatment The important phenotypic characteristics of metastatic phase in breast cancer cells are regulated by IGF system which included survival, growth and metastasis (Figueroa and Yee, 1992).	cache/bjp-23565.pdf	txt/bjp-23565.txt