id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bjp-2980	Thakare, Sagar P.; Jain, Hitesh N.; Patil, Savita D.; Upadhyay, Umesh M.	Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats	2009	6	.pdf	application/pdf	3445	199	54	Bile duct ligation induces imbalance between reactive oxygen species production and these anti-oxidant defense which results into oxidative stress through a series of events deregulates the cellular functions leading to hepatic damage (Sanmugapriya Bangladesh J Pharmacol 2009; 4: 126-130 129 Table III Effect of methanol extract of Cocculus hirsutus on glutathione level in bile duct ligated rats Group Gluthathione level μmol/mg of protein Normal saline treated 1.8 ± 0.0 Bile duct ligated 0.8 ± 0.0 Silymarin treated (50 mg/kg) 1.7 ± 0.0 Cocculus hirsutus extract (400 mg/kg) 1.4 ± 0.0 A B C D E F G Figure 1: (A) Histology of normal liver showing normal hepatocyte, prominent central vein and sinosoids; (B) Bile duct ligated liver showing necrosis and portal inflammation, lymphocyte infiltration; C) Sham treated liver showing normal liver histology, prominent central vein and hepatocytes; D) Silymarin-treated liver showing necrosis and portal inflammation decreases compared with bile duct ligation; E) Methanol extract (100 mg/kg) showing mild bile duct proliferation and portal inflammation; F) Metha- nol extract (200 mg/kg) showing few area of necrosis and fatty change are seen; G) Methanol extract (400 mg/kg) showing small areas of lymphocyte infiltration and restoration of cells near to normal are seen (Hematoxylin and Eosin stain X 100) and Venkataraman, 2006). Lee TY, Chang HH, Chenjenn H. Herb medicine ameliorates hepatic fibrosis in bile duct ligation rats.	cache/bjp-2980.pdf	txt/bjp-2980.txt