id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bjp-36597	Vasudev, Shwetha; More, Sunil Shivajirao; Annappa, Gautham Santhekadur; More, Veena Sunil	Anti-snake venom potential of Clerodendrum serratum extracts on Bungarus caeruleus and Daboia russelii venom	2018	6	.pdf	application/pdf	3481	171	50	In the present study, inhibition was performed on three enzymes of snake venom namely PLA2, protease and hyaluronidase, also known as major enzyme toxins (METs) which if inhibited will be efficient in neutralizing the toxic effects of snake venom, although all extracts of C. serratum has shown inhibitions, on krait venom, the plant extracts were not able to efficiently inhibit D. russelii venom enzymes. Minimum fibrinogenolytic activity of B. cearuleus venom was observed at a concentration of 5 µg where A band was degraded and same was observed at concentration of 10 and 15 µg, whereas D. russelii- induced degradation of both A and B band at a minimum concentration of 5 µg, further increase in venom concentration up to 10 and 15 µg showed similar Table I Activity of B. Caeruleus and D. russelii venom on enzymes Enzymes Specific activity B. caeruleus D. russelii Protease (μM/ hour/mg) 1.2 ± 0.1 1.4 ± 0.1 PLA2 (U/mg) 634.2 ± 42.4 260.0 ± 35.3 Hyaluronidase (TRU/min/mg) 1.3 ± 0.8 0.5 ± 0.0 140 120 100 80 60 40 20 0 -20 B. caeruleus Venom P. ether Chl E. acetate Meth Figure 1: In vitro inhibition studies of C. serratum plant extracts against the MET’s of B. caeruleus venom (A) and D. russelii venom (B).	cache/bjp-36597.pdf	txt/bjp-36597.txt