id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bjp-84621	Arshad, Hanzla; Afridi, Muhammad Shahbaz Khan	Experimental and computational evidence for xanthatin as a multi-target anti-cancer agent in ovarian cancer	2025	12	.pdf	application/pdf	6579	289	51	Collectively, these pathways converge to protect ovarian cancer cells from taxanes and other agents, highlighting the translational importance of therapeutic strategies that disrupt redox homeostasis, inhibit efflux mechanisms, and reactivate mitochondrial apoptosis (Wang et al., 2024; Alrosan et al., 2025; Tossetta et al., 2022; He et al., 2021; Chuwa and Mvunta, 2024). Consequently, it remains unclear whether purified xanthatin can induce ROS-dependent mitochondrial apoptosis in ovarian cancer cells, modu- late resistance factors such as ABCB1/P-glycoprotein, NRF2, PI3K/AKT, and survivin, and impair migratory behavior compared to a clinical benchmark (paclitaxel) under dose-calibrated, solvent-controlled conditions.	cache/bjp-84621.pdf	txt/bjp-84621.txt