item: #1 of 942 id: bjp-10007 author: Madeswaran, Arumugam; Umamaheswari, Muthuswamy; Asokkumar, Kuppuswamy; Sivashanmugam, Thirumalaisamy; Subhadradevi, Varadharajan; Jagannath, Puliyath title: Discovery of potential cyclooxygenase inhibitors using in silico docking studies date: 2012 words: 3280 flesch: 58 summary: Intermolecular energy is also directly proportional to binding energy. Three important parameters like binding energy, inhibition constant and intermolecular energy were determined. keywords: autodock; binding; compounds; cyclooxygenase; docking; energy; flavonoids; kcalmol-1; rhamnetin cache: bjp-10007.pdf plain text: bjp-10007.txt item: #2 of 942 id: bjp-10066 author: Rasul, Azhar; Parveen, Saima; Ma, Tonghui title: Costunolide: A novel anti-cancer sesquiterpene lactone date: 2012 words: 5484 flesch: 55 summary: Further studies demonstrate that costunolide has anti- tumor potential by inhibiting proliferation, inducing apoptosis and reducing invasion and metastasis of a wide variety of tumor cells, including breast cancer cells (Bocca et al., 2004; Choi et al., 2005; Choi et al., 2011), hepatocellular carcinoma cells (Chen et al., 1995; Liu et al., 2011a; Sun et al., 2003), prostate cancer cells (Hsu et al., 2011), leukemia cells (Choi et al., 2002a; Choi and Lee, 2009; Choi et al., 2002b; Hibasami et al., 2003; Kanno et al., 2008; Kim et al., 2008; Kim et al., 2002; Kim et al., 2011b; Komiya et al., 2004; Lee et al., 2001; Song et al., 2001; Srivastava et al., 2006), gastric cancer cells (Ko et al., 2005; Rasul et al., 2011), colon cancer cells (Kawamori et al., 1995; Mori et al., 1994), melanoma cells (Chen et al., 2007; Park et al., 2001b), cervical cancer cells (Sun et al., 2003), KB and P388 tumor cell (Mondranondra et al., 1990), and platinum-resistant human ovarian cancer cells (Yang et al., 2011). Accumulated data indicate that Costunolide was isola- ted from many plant species such as Saussurea lappa (Lee et al., 2001; Li et al., 2006; Zhang et al., 2011), Aucklandia lappa Decne (Li et al., 2005; Rasul et al., 2011), Michelia floribunda (Mondranondra et al., 1990), Magnolia grandiflora (el-Feraly and Chan, 1978; Wu et al., 2001), Podachaenium eminens (Castro et al., 2000), Magnolia sieboldii (Park et al., 2001a; Park et al., 2001b), Tsoongiodendron odorum Chun (Song et al., 2001), Cosmos pringlei (Mata et al., 2002), Laurus nobilis (De Marino et al., 2005; Matsuda et al., 2002), Laurus novocanariensis (Ferrari et al., 2005), Magnolia kobus (Park et al., 2010), Eupatorium lindleyanum (Yang et al., 2010), and Magnolia ovata (Kassuya et al., 2009). keywords: activity; anti; apoptosis; cancer; cancer cells; cells; choi; choi et; costunolide; et al; human; kim; lactone; lee; park; park et; pharmacol; res; sesquiterpene; tumor cache: bjp-10066.pdf plain text: bjp-10066.txt item: #3 of 942 id: bjp-10084 author: Azam, Asma; Anjum, Tehmina; Irum, Wajiha title: Trichoderma harzianum : A new fungal source for the production of cyclosporin A date: 2012 words: 2089 flesch: 56 summary: Although cyclosporin A was initially developed as an antifungal antibiotic (Deo et al., 1984), it is currently prescribed as one of the most important immunosuppressive drugs for the treatment of organ transplants, as well as patients with auto- immune diseases, including AIDS, owing to its superior T-cell specificity and low levels of myelotoxicity (Borel, 1986). A analysis Level of cyclosporin A in the crude extract was analy- zed by high performance liquid chromatography (HPLC). keywords: cyclosporin; medium; peak; production; trichoderma cache: bjp-10084.pdf plain text: bjp-10084.txt item: #4 of 942 id: bjp-10119 author: Öcal, Afide; Eroğlu, Halil Erhan title: In vitro cytogenetic effects of Hypericum heterophyllum in human peripheral blood lymphocytes date: 2012 words: 2423 flesch: 55 summary: Materials and Methods Preparation of the extracts Aqueous extracts (AE) (decoction) were prepared by A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2012; 7: 36-41 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index; ISSN: 1991-0088 Bangladesh J Pharmacol. keywords: effects; heterophyllum; hypericum; index cache: bjp-10119.pdf plain text: bjp-10119.txt item: #5 of 942 id: bjp-10120 author: Ashafa, Anofi Omotayo Tom; Yakubu, Musa Toyin; Ogbe, Abdul-Azeez Adeola; Abass, Aishat Abidemi title: Effect of ethanolic seed extract of Croton penduliflorous Hutch. on loperamide-induced constipated male rats date: 2012 words: 3425 flesch: 55 summary: Table I Effect of administration of loperamide on feed intake, water intake, and fecal parameters of rats Parameters Normal control Loperamide-induced constipated animals Feed intake (g) 16.8 ± 1.2a 8.8 ± 1.0b Water intake (g) 20.9 ± 1.3a 9.8 ± 0.8b Number of fecal pellets 71.1 ± 3.8a 26.4 ± 1.0b Water content of fecal pellets (g) 1.7 ± 0.2a 0.6 ± 0.1b Weight of fecal pellets (g) 7.0 ± 0.5a 3.2 ± 0.1b n = 6 ± SEM; Values for each parameter carrying superscript different from the non-constipated control are significantly different (p<0.05); Values in brackets are the computed percentage decrease Table II Effect of ethanolic seed extract of C. penduliflorus on some indices of constipation Parameters Constipat- ed control Senekot (5 mg/ kg b/w) Constipated animals plus Extract (mg/kg body weight) Abstract The laxative effect of ethanolic seed extract of Croton penduliflorus was evaluated in loperamide-induced constipated male rats on daily basis for 7 days. keywords: animals; body; body weight; constipation; extract; kg body; loperamide; water; weight cache: bjp-10120.pdf plain text: bjp-10120.txt item: #6 of 942 id: bjp-10156 author: Kumar, Gaurav; Karthik, Loganathan; Kokati Venkata, Bhaskara Rao; Kirthi, Arivarasan Vishnu; Jayaseelan, Chidambaram; Rahuman, Abdul Abdul title: Phytochemical composition, mosquito larvicidal, ovicidal and repellent activity of Calotropis procera against Culex tritaeniorhynchus and Culex gelidus date: 2012 words: 4917 flesch: 58 summary: Bangladesh Journal of Pharmacology Research Article Phytochemical composition, mosqui-Phytochemical composition, mosqui-Phytochemical composition, mosqui- to larvicidal, ovicidal and repellent to larvicidal, ovicidal and repellent to larvicidal, ovicidal and repellent activity of activity of activity of Calotropis procera Calotropis procera Calotropis procera against against against Culex tritaeniorhynchus Culex tritaeniorhynchus Culex tritaeniorhynchus and and and Culex Culex Culex gelidusgelidusgelidus BJP Introduction Japanese encephalitis (JE) is a virus born disease of humans and animals, caused by JE virus (Flaviviridae). Aqueous extract of C. procera leaves (1,000 ppm) exhibited 100% larvicidal activity against fourth instar larvae of Culex tritaeniorhynchus and Cx. keywords: activity; calotropis; culex; extract; gelidus; larvicidal; leaves; mosquito; procera; repellent; tritaeniorhynchus cache: bjp-10156.pdf plain text: bjp-10156.txt item: #7 of 942 id: bjp-10194 author: Yue, Tianli; Bai, Xuelian; Zhang, Huawei; Yuan, Yahong title: Fractionation and anti-inflammatory effects of polyphenol-enriched extracts from apple pomace date: 2012 words: 3283 flesch: 56 summary: In order to identify the potential contributor(s) of inhi- biting COX-2 protein expression in polyphenolenriched Table I Mean content of total phenolics and phenolic compounds of fractions API-IV Compound API APII APIII APIV APV APVI Total phenolicsa 52.9 ± 3.2 58.2 ± 2.5 148.1 ± 3.1 64.9 ± 2.1 - - Chlorogenic acidb 0.14 ± 0.02 0.31 ± 0.03 2.84 ± 0.1 1.90 ± 0.1 - - Syringinb 0.18 ± 0.03 0.23 ± 0.02 1.22 ± 0.1 0.14 ± 0.01 - - Procyanidin B2b 1.7 ± 0.1 2.6 ± 0.2 92.6 ± 2.2 - - - Caffeic acidb - 0.15 ± 0.02 0.13 ± 0.01 0.16 ± 0.01 - - Cinnamic acidb 0.88 ± 0.1 0.12 ± 0.01 0.19 ± 0.02 - - - Phlorizinb - 0.19 ± 0.02 - 0.18 ± 0.02 - - Quercetinb - 5.5 ± 0.2 46.7 ± 1.3 19.6 ± 0.5 - - Hyperinb - - 1.5 ± 0.11 8.9 ± 0.3 - - “-” represents no detection; Values are mean ± SD of three determinations; aExpressed as mg gallic acid equivalent per 100 g of dry apple pomace (mg GAE 100 g-1); bExpressed as mg per 1000 g of dry apple pomace (mg kg-1) 30 Bangladesh J Pharmacol 2012; 7: 28-32 extract of apple pomace, nine phenolic standards were used to anti-inflammatory assay. Fractionation and anti-inflammatory effects of polyphenol enriched extracts from apple pomace keywords: acid; analysis; anti; apple; cox-2; food; fractions; lps; phenolic; pomace cache: bjp-10194.pdf plain text: bjp-10194.txt item: #8 of 942 id: bjp-10230 author: Khan, Imran; Singh, Vandana; Chaudhary, Amrendra Kumar title: Hepatoprotective activity of Pinus roxburghii Sarg. wood oil against carbon tetrachloride and ethanol induced hepatotoxicity date: 2012 words: 3876 flesch: 56 summary: The wood oil was obtained by hydro distillation of P. roxburghii wood and the % yield of light yellow color wood oil was found to be 0.5% w/v. The phytochemical testing of wood oil of P. roxburghii was done in order to determine the presence of different constituents. In the study, wood oil of P. roxburghii was administered in 200, 300 and 400 mg/kg dosage. keywords: ccl4; group; hepatoprotective; oil; pinus; roxburghii; test; wood cache: bjp-10230.pdf plain text: bjp-10230.txt item: #9 of 942 id: bjp-1035 author: Al Masud, Mohammad Abdullah; Ashrafuzzaman, Syed; Iqbal, Md. Jalaluddin title: Pattern of use of analgesics in a surgical unit date: 2008 words: 1897 flesch: 51 summary: Abstract The present study was designed to evaluate the prescribing pattern of analge- sics in post-operative patients in a surgical unit. Over the past decade, medical societies, governmental agencies, and accredi- ting bodies such as the Joint Commission on Accredi- tation of Healthcare Organizations (JCAHO) have paid increasing attention to the management of all types of pain, including post-operative pain (Michael, 2006). keywords: day; pain; patients; post cache: bjp-1035.pdf plain text: bjp-1035.txt item: #10 of 942 id: bjp-10356 author: Hamlaoui, Sonia; Mokni, Meherzia; Limam, Nadia; Carrier, Alice; Limam, Ferid; Amri, Mohamed; Marzouki, Lamjed; Aouani, Ezzedine title: Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma date: 2012 words: 5418 flesch: 57 summary: GSSE is a complex mixture of polyphenolics classified as flavonoid and non flavonoid compounds (Khanal et al., 2009). GSSE also protects against hepatic ischemia-reperfusion injury (Sehirli et al., 2008), biliary obstruction (Dulundu et al., 2007), and azathioprine- induced hepatotoxicity in rats (El-Ashmawy et al., 2010). keywords: activity; anti; dox; doxorubicin; effect; erythrocytes; et al; extract; figure; free; grape; gsse; h2o2; plasma; seed; sod; stress cache: bjp-10356.pdf plain text: bjp-10356.txt item: #11 of 942 id: bjp-1040 author: Koba, Koffi; Sanda, Komla; Guyon, Catherine; Raynaud, Christine; Chaumont, Jean-Pierre; Nicod, Laurence title: In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo date: 2008 words: 3851 flesch: 54 summary: You must attribute the work in the manner specified by the author or licensor The objective of this paper was to investigate chemical composition and the in vitro cytotoxic potential of C. citratus and C. nardus essential oils. The next day, the medium was removed and cells were incubated in FCS-free medium containing increasing concentrations (from 50 to 1,000 30 Bangladesh J Pharmacol 2009; 4: 29-34 µL.mL-1) of C. citratus, C. nardus essential oils or their major components from commercial origin (Pure neral, geranial, citronellal and geraniol) solubilized in 1/10 Tween 80® in culture medium (with <0.1% Tween 80® an ethanol vehicle). keywords: cell; citratus; cymbopogon; geranial; nardus; neral; oils cache: bjp-1040.pdf plain text: bjp-1040.txt item: #12 of 942 id: bjp-10482 author: Hamlaoui, Sonia; Samti, Oumayma; Mokni, Meherzia; Limam, Nadia; Carrier, Alice; Limam, Ferid; Amri, Mohamed; Aouani, Ezzedine; Marzouki, Lamjed title: Protective effect of grape seed and skin extract on high dosage garlic-induced renal oxidative stress date: 2012 words: 7000 flesch: 59 summary: Mokni M, Hamlaoui-Guesmi S, Amri M et al. We observed an increase in plasma free iron (Hamlaoui- Gasmi et al., 2011b) that could result from its extrusion from the kidney. keywords: activity; calcium; effect; et al; extract; figure; free; garlic; grape; gsse; h2o2; iron; kidney; pharmacol; protective; rats; resveratrol; seed; skin; stress cache: bjp-10482.pdf plain text: bjp-10482.txt item: #13 of 942 id: bjp-1049 author: Kanodia, Lalit; Das, Swarnamoni title: A comparative study of analgesic property of whole plant and fruit extracts of Fragaria vesca in experimental animal models date: 2008 words: 2529 flesch: 63 summary: Fruit extract, whole plant extract and aspirin showed significant analgesic activity, both central and peripheral, as compared to control (p<0.01). The central analgesic activity of fruit extract at 500 mg/kg was significantly more than fruit extract at 250 mg/kg and whole plant extract at 500 mg/kg (p<0.05); although when compared to standard, aspirin showed significantly more analgesic activity (p<0.05) than fruit extract 500 mg/kg (except at 15 and 30 min), fruit extract 250 mg/kg and whole plant extract (Table I). keywords: analgesic; extract; fruit; plant cache: bjp-1049.pdf plain text: bjp-1049.txt item: #14 of 942 id: bjp-10499 author: Sheng, Lin; Bi, Shaojie; Cheng, Chao; Zhang, Jingbo title: Hydroxysafflor yellow A suppresses oxidized low density lipoprotein induced proliferation of vascular smooth muscle cells date: 2012 words: 4179 flesch: 60 summary: In the PD98059+ox-LDL group, the mRNA expression of ERK1/2 was reduced by 45.9% when compared with ox-LDL group but that of MAKP-1 remained unchanged. In the oxLDL + PD98059 group, the p-ERK1/2 protein expression was significantly reduced by 45.9% when compared with ox-LDL group (p<0.01), but the MAKP-1 expression remains unchanged. keywords: cells; erk1/2; expression; group; hsya; ldl; makp-1; proliferation; protein cache: bjp-10499.pdf plain text: bjp-10499.txt item: #15 of 942 id: bjp-10507 author: Shoeb, Mohammad; Thoo-Lin, Paul Kong; Nahar, Nilufar title: Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt date: 2012 words: 2015 flesch: 57 summary: Cryopreservation of cancer cells CaCo-2, human colon cancer cell line was obtained from the European collection of cell cultures. Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt Mohammad Shoeb1, Paul Kong Thoo-Lin2 and Nilufar Nahar1 1Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh; 2School of Pharmacy and Life Science, The Robert Gordon University, Aberdeen AB25, 1HG, UK. keywords: bangladesh; cancer; cell; chebula; ir-6; strains cache: bjp-10507.pdf plain text: bjp-10507.txt item: #16 of 942 id: bjp-1051 author: Bhuiyan, Md. Nurul Huda; Bhuiyan, Habibur Rahman; Ahmed, Kabir; Dawlatana, Mamtaz; Haque, K. M. Formuzul; Rahim, Matiur; Bhuiyan, Md. Nazrul Islam title: Organochlorine insecticides (DDT and heptachlor) in dry fish: Traditional washing and cooking effect on dietary intake date: 2008 words: 3368 flesch: 62 summary: An aliquot of dry fish samples which were collected as blank and treated exactly as a sample including exposure to all glassware, equipments, solvents and reagents used with the sample matrix. For protection of dry fish from infestation they use a mixture of organochlorine (DDT and heptachlor) insecticides (Bhuiyan et al., 2008). keywords: bangladesh; boiling; ddt; fish; heptachlor; samples; solution; treatment; washing cache: bjp-1051.pdf plain text: bjp-1051.txt item: #17 of 942 id: bjp-1052 author: Muralidharan, P.; Balamurugan, G.; Babu, Venu title: Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract date: 2008 words: 3852 flesch: 58 summary: Results The preliminary phytochemical screening carried out on aqueous extract of G. glabra revealed the presence of phytoconstituents such as alkaloids, carbohydrates, saponins, triterpenoids, flavanoids and flavones. The present study has revealed the neuroprotective effect of aqueous extract of G. glabra on sodium nitrite induced hypoxia deficits in rats. keywords: activity; extract; glabra; group; hypoxia; min; rats; water cache: bjp-1052.pdf plain text: bjp-1052.txt item: #18 of 942 id: bjp-10558 author: Saha, Monika Rani; Debnath, Pankaj Chandra; Rahman, Md. Ajijur; Islam, Md. Anwar Ul title: Evaluation of in vitro anthelmintic activities of leaf and stem extracts of Justicia gendarussa date: 2012 words: 2902 flesch: 64 summary: This is the first report of anthelmintic activities of J. gendarussa. Anthelmintic activity of Callistemon viminalis. keywords: activities; activity; anthelmintic; extract; gendarussa; leaves; time cache: bjp-10558.pdf plain text: bjp-10558.txt item: #19 of 942 id: bjp-10595 author: Madeswaran, Arumugam; Umamaheswari, Muthuswamy; Asokkumar, Kuppusamy; Sivashanmugam, Thirumalaisamy; Subhadradevi, Varadharajan; Jagannath, Puliyath title: Docking studies: In silico phosphodiesterase inhibitory activity of commercially available flavonoids date: 2012 words: 3530 flesch: 53 summary: Analysis of the receptor/ligand complex models generated after successful docking of the flavonoids was based on the parameters such as hydrogen bond interactions, п – п interactions, binding energy, RMSD of active site residues and orientation of the docked compound within the active site (Madeswaran et al., 2012). Binding energy of the individual compounds were calculated using the following formula, Binding energy = A + B + C - D keywords: activity; autodock; binding; compounds; docking; energy; flavonoids; mol; phosphodiesterase cache: bjp-10595.pdf plain text: bjp-10595.txt item: #20 of 942 id: bjp-1062 author: Mirza, Nazima Yunus; Desai, Sagun; Ganguly, Barna title: Prescribing pattern in a pediatric out-patient department in Gujarat date: 2008 words: 2793 flesch: 55 summary: Essential medicines or fixed-dose drug combinations were allotted the score of 2 while non- essential were assigned the score of 0. Essential medicines and rational use of medicines are two sides of a coin – inseparable from each other and mutually dependent. keywords: appropriateness; dose; drug; medicines; prescription; score cache: bjp-1062.pdf plain text: bjp-1062.txt item: #21 of 942 id: bjp-1065 author: Samad, Md. Khoshroz title: Consumption patterns of non-steroidal anti-inflammatory drugs by the community without prescription in Dhaka City date: 2008 words: 2157 flesch: 64 summary: The total cost of purchased NSAIDs per encounter were ‘less than Tk. 5’ (6.9%); ‘5 to less Tk. 10’ (45.4%); which were almost half of total encounters; Tk. 10-25 (32.5%) and ‘more than Tk. 25’ (12.2%) (Table II). Education status of the encounters 'below S.S.C.' (38.0%); S.S.C qualified (16.8%); H.S.C.(25.0%) ‘graduate’ (11.2%); post-graduate (9.0%) were observed. keywords: drugs; encounters; nsaids; prescription; study; total cache: bjp-1065.pdf plain text: bjp-1065.txt item: #22 of 942 id: bjp-10760 author: Begum, Zinnat Ara; Sultana, Sayeeda; Umar, Badar Uddin; Ferdous, A. H.; Uddin, Md. Kamal; Islam, S. M. Hasibul title: Study of adverse drug reactions in out-patient departments of a teaching hospital date: 2012 words: 2742 flesch: 61 summary: The study conducted in the Medicine and Skin outpatient Departments of Dhaka Medical College, Dhaka revealed 19 cases (7 males, 12 females) of adverse drug reactions (ADR) out of 160 patients. Study of adverse drug reactions in out -patient departments of a teaching hospital. keywords: adr; adrs; bangladesh; drug; et al; reactions; study cache: bjp-10760.pdf plain text: bjp-10760.txt item: #23 of 942 id: bjp-10779 author: Umamaheswari, Muthuswamy; Aji, C. S.; Asokkumar, Kuppuswamy; Sivsshanmugam, Thirumalaisamy; Subhadradevi, Varadharajan; Jagannath, Puliyath; Madeswaran, Arumugam title: Docking studies: In silico aldose reductase inhibitory activity of commercially available flavonoids date: 2012 words: 3224 flesch: 54 summary: Figure 3: Docked pose of aldose reductase enzyme (3RX3) with communin-A and epalrestat communin-A have better binding sites and interactions with aldose reductase enzyme. In silico docking study, was carried out to identify the inhibiting potential of selected flavonoids against aldose reductase enzyme (Figure 2). keywords: -5.6; aldose; binding; communin; docking; energy; flavonoids; mol; reductase cache: bjp-10779.pdf plain text: bjp-10779.txt item: #24 of 942 id: bjp-10800 author: Xia, Jian-Xin; Li, Fu-Qiu; Urabe, Kazunori; Wang, Jin-Feng; Furue, Masutaka title: Imatinib inhibits migration of normal human epidermal melanocytes and suppress the phosphorylation of C-kit date: 2012 words: 2874 flesch: 54 summary: Imatinib at 0.1, 1.0 and 5.0 μM could inhibit the SCF (50 ng/mL) induced NHEM migration and suppress the phosphorylation of c-kit in NHEM. Detection of effect of imatinib on NHEM migration The 24-well Boyden chamber was employed for detec- tion of effect of imatinib on NHEM migration. keywords: imatinib; kit; nhem; scf cache: bjp-10800.pdf plain text: bjp-10800.txt item: #25 of 942 id: bjp-1081 author: Rasilingam, Duraisami; Duraisamy, Srinivasan; Subramanian, Ramaswamy title: Anticonvulsant activity of bioflavonoid gossypin date: 2008 words: 2349 flesch: 50 summary: Clinical significance of animal seizure models and mechanism of action, studies of potential antiepileptic drugs. Pentelenetetrazole- or strychnine-induced seizure model In each type of seizure model, the mice were divided into five groups with six animals. keywords: activity; anticonvulsant; convulsion; drugs; electroshock; gossypin; seizure cache: bjp-1081.pdf plain text: bjp-1081.txt item: #26 of 942 id: bjp-10815 author: Yang, Zhan-Nan; Zhu, Shi-Qiong; Yu, Zheng-Wen title: Comparison of terpene components from flowers of Artemisia annua date: 2012 words: 3024 flesch: 56 summary: Abstract Terpene constituents of essential oils obtained by steam distillation from Artemisia annua flowers at the pre-, full- and post-flowering stage was investigated by gas chromatography (GC) and gas chromatography-mass spectrometric detector (GC-MS). The samples studied showed that main components of essential oils were monoterpenes hydrocarbons (48.1%) and oxygenated monoterpenes (41%) in the pre- flowering, oxygenated monoterpenes (35.6%) and sesquiterpenes hydro- carbons (5.0%) in the full-flowering, and oxygenated monoterpenes (29.6%), sesquiterpenes hydrocarbons (32.2%) and oxygenated sesquiterpenes (25.3%) in the post-flowering, respectively. keywords: annua; artemisia; flowering; monoterpenes; oil; oils; sesquiterpenes cache: bjp-10815.pdf plain text: bjp-10815.txt item: #27 of 942 id: bjp-1083 author: Lakshmi, V.; Saxena, A.; Mishra, S. K.; Mishra, M.; Srivastava, S.; Ghoshal, S. title: Antiamoebic activity of marine sponge Haliclona exigua (Krikpatrick) date: 2008 words: 3371 flesch: 58 summary: Test models and methodology for antiamebic activity (in vitro model) Axenic culture of E. histoyitica (200: NIH) maintained TYI-S-33 medium (Diamond et al., 1978) has been used for in vitro screening. 4: 55-59 57 Table I Antiamebic activity of Haliclona exigua against E. histolytica in in vitro and in vivo models Name of the extracts/fractions/compounds Antiamebic activity against E. histolytica In vitro MIC (mg/mL) keywords: activity; days; dose; extract; marine; methanol; rats cache: bjp-1083.pdf plain text: bjp-1083.txt item: #28 of 942 id: bjp-10894 author: Das, Surya Narayan; Patro, Varanasi Jagannath; Dinda, Subas Chandra title: Antimicrobial activity of Leucas clarkei date: 2012 words: 3403 flesch: 56 summary: The screening of plant extracts and their pro- ducts for antimicrobial activity has shown that, higher plants represent potential sources of novel antibiotic prototypes (Aliero and Afolayan, 2006; Afolayan, 2003). Antibac- terial activity of plant extracts and phytochemicals on anti- biotic resistant bacteria. keywords: activity; bacteria; clarkei; disc; extracts; leucas; plant; test cache: bjp-10894.pdf plain text: bjp-10894.txt item: #29 of 942 id: bjp-10951 author: Zhang, Huawei; Bai, Xuelian; Wu, Baixu title: Evaluation of antimicrobial activities of extracts of endophytic fungi from Artemisia annua date: 2012 words: 2480 flesch: 53 summary: Bangladesh Journal of Pharmacology Research Article Evaluation of antiEvaluation of antiEvaluation of anti---microbial activi-microbial activi-microbial activi- ties of extracts of endophytic fungi ties of extracts of endophytic fungi ties of extracts of endophytic fungi from from from Artemisia annuaArtemisia annuaArtemisia annua BJP Introduction Infectious diseases are the world’s leading cause of premature deaths, killing almost 50 thousand people every day. 20 June 2012 Accepted: 23 June 2012 Available Online: 1 July 2012 DOI: 10.3329/bjp.v7i2.10951 Cite this article: Zhang H, Bai X, Wu B. Evaluation of anti-microbial activities of extracts of endophytic fungi from Artemisia an- nua. keywords: + +; annua; aspergillus; fungi; zhang cache: bjp-10951.pdf plain text: bjp-10951.txt item: #30 of 942 id: bjp-10973 author: Abu Bakar, Ruzilawati; Ahmad, Imran; Sulaiman, Shaida Fariza title: Effect of Pithecellobium jiringa as antimicrobial agent date: 2012 words: 2199 flesch: 54 summary: The estimate of the MIC was carried by using P. jiringa leaf extract against the organisms. Effect of P. jiringa leaf extract on B. subtilis Two milliliter of B.subtilis suspension was added into nutrient broth containing P. jiringa leaf crude extract to give a final dilution of 250 mg/mL. keywords: extract; inhibition; jiringa; leaf; mic; pithecellobium cache: bjp-10973.pdf plain text: bjp-10973.txt item: #31 of 942 id: bjp-10993 author: Gong, Fayong; Li, Fenglin; Zhang, Wanming; Li, Jing; Zhang, Zhong title: Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice date: 2012 words: 3970 flesch: 59 summary: After induction of diabetes, diabetic mice were randomly divided into four groups: One diabetic control group and three different doses of FTB (100, 200 and 400 mg/kg) treated groups, with non-diabetic mice used as the normal control group. In addition, we have reported that FTB have hypoglycemic effects in diabetic mice (Li et al., 2012). keywords: buckwheat; diabetic; effects; ftb; group; mice; stress cache: bjp-10993.pdf plain text: bjp-10993.txt item: #32 of 942 id: bjp-11034 author: Haq, A. M. Mujibul; Huque, Md. Mahbubul; Chaudhury, Shah Abdur Rahman; Haque, Mohammad Nurul title: Cardiotonic effects of Terminalia arjuna extracts on guinea pig heart in vitro date: 2012 words: 2893 flesch: 62 summary: The comparative effects of normal saline and bark extract of T. arjuna on guinea pig heart contraction in vitro are presented in Table II. Since the studies in mice showing its leaves to have analgesic and anti-inflammatory properties, T. arjuna has found its way in traditional/alternative medicine for treatment of a wide range of human ailments. keywords: arjuna; bark; extract; fruit; guinea; heart cache: bjp-11034.pdf plain text: bjp-11034.txt item: #33 of 942 id: bjp-11094 author: Huang, Damin; Lu, Yingmin; Luo, Xiaohan; Shi, Laixin; Zhang, Jinchun; Shen, Junxian; Bao, Minmin; Song, Lei; Wei, Caiwen; Li, Hongsong; Li, Zhihua title: Effect of safflower yellow on platelet activating factor mediated platelet activation in patients with coronary heart disease date: 2012 words: 3631 flesch: 54 summary: Safflower yellow 1.6 20.8 ± 2.1a 81.2a (n= 3, x ± s); ap<0.05 vs normal saline group Table II Effect of safflower yellow on PAF (2.0×10- 9 mol/L) induced 5-HT release by platelets Group Concentration (pg/L) Safflower can improve the hypercoagulable state in different ways: 1) safflower can inhibit the activity of platelets to affect the adhe- rence, aggregation of platelets and release of infla- mmatory factors by platelets, which inhibit the initial step in the thrombosis; thus safflower yellow can inhibit the formation of arterial thrombus the major ingredient of which is platelet. keywords: aggregation; calcium; effect; free; group; paf; platelet; safflower; yellow cache: bjp-11094.pdf plain text: bjp-11094.txt item: #34 of 942 id: bjp-11148 author: Subbiah, Murugesan; Sundaresan, Bhuavaneswari title: Antitumor activity of Chondrococcus hornemanni and Spyridia fusiformis on Dalton’s lymphoma ascites in mice date: 2012 words: 3507 flesch: 57 summary: However, in the present study an increase in body weight, packed tumor cell volume and number of viable tumor cells was found to be significantly less than the tumor control animals, indicating the anticancer nature of the extract. These results could indicate either a direct cytotoxic effect of C. hornemanni and S. fusiformis on tumor cells as evidenced by the in vitro studies or an indirect local effect, which may involve macrophage activation and vascular permea- bility inhibition. keywords: activity; antitumor; cancer; cell; control; fusiformis; group; hornemanni; mice; tumor cache: bjp-11148.pdf plain text: bjp-11148.txt item: #35 of 942 id: bjp-11228 author: Sun, Qin; Shui, Pi-Xian; Li, Han-Bin; Yang, Si-Jin; Liu, Ming-Hua; Zhang, Shi-Jing title: In vitro anti-viral effect of fructopyrano-(1→4)-glucopyranose from Radix isatidis on infuenza virus A date: 2012 words: 3280 flesch: 54 summary: Group A: When compared with virus control group, the virus inhibition rate and cell protection rate following FG treatment were markedly increased (p<0.01). 2) Group B: When compared with virus control group, the virus inhibition rate and cell protection rate following FG treatment were markedly increased (p<0.01). keywords: cells; control; effect; group; inhibition; rate; virus cache: bjp-11228.pdf plain text: bjp-11228.txt item: #36 of 942 id: bjp-11275 author: Mumtaz, Sayeed Mohammed Firdous; Ahmed, Shafique; Dey, Samiran title: Antiepileptic and central nervous system depressant activity of Sechium edule fruit extract date: 2012 words: 2629 flesch: 59 summary: The extracts of the seeds of S. edule contain twenty known Gibberellins. Gibberellins A8 and gibberlin A8 -catabolites are the major gibberellins found in S. edule (Albone et al., 1984). keywords: edule; ethanol; extract; fruits; rats cache: bjp-11275.pdf plain text: bjp-11275.txt item: #37 of 942 id: bjp-11298 author: Li, Xiaofei; Lou, Lianqing; Wu, Shuang; Chen, Yongxin; Jin, Lingzhen title: Effects of neferine on TGF-β1 induced proliferation and gremlin expression in hepatic stellate cells date: 2012 words: 2971 flesch: 55 summary: To date, the activation of hepatic stellate cells (HSC) induced imbalance between the production of ECM and degradation of ECO has been considered as a key step in the occurrence and development of hepatic fibrosis (Tacke and Weiskirchen, 2010). High-glucose DMEM (H- DMEM), trypsin, fetal bovine serum (FBS; Gibco), recombinant human TGF- 1 (R＆ D), reagents for RNA extraction, primers for PCR, PCR kit (TaKaRa), rabbit anti-rat gremlin polyclonal antibody (Santa Cruz), A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2012; 7: 169-172 Journal homepage: www.banglajol.info; www.bdjpharmacol.com Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088 Effects of neferine on TGF- 1 induced proliferation and gremlin expression in hepatic stellate cells keywords: cells; expression; fibrosis; gremlin; nef; proliferation; tgf1 cache: bjp-11298.pdf plain text: bjp-11298.txt item: #38 of 942 id: bjp-11435 author: Ghosh, Amalendu; Awal, Md. Abdul; Majumder, Shankar; Sikder, Mahmudul Hasan; Rao, Damanna Ramkishan title: Arsenic residues in broiler meat and excreta at arsenic prone areas of Bangladesh date: 2012 words: 5439 flesch: 55 summary: Statistical analyses Information regarding broiler chickens were stratified according to area, age, sex, drinking water source and arsenic levels in drinking water and feed. The overall levels (µg/kg) of arsenic in thigh muscle, liver, kidney, lung and skin of broiler chickens were 67.8 ± 5.1, 102.1 ± 180 Bangladesh J Pharmacol 2012; 7: 178-185 Table I Numbers of broiler chickens by geographic area, age, consumption of feed type, drinking water source, and ranges of arsenic levels in drinking water and feed (n = 232) keywords: arsenic; bangladesh; broiler; chickens; drinking; drinking water; excreta; feed; liver; muscle; skin; tissues; water cache: bjp-11435.pdf plain text: bjp-11435.txt item: #39 of 942 id: bjp-11437 author: Molefe, Nthatisi Innocentia; Tsotetsi, Ana Mbokeleng; Ashafa, Anofi Omotayo Tom; Thekisoe, Oriel Matlhahane Molefi title: In vitro anthelmintic effects of Artemisia afra and Mentha longifolia against parasitic gastro-intestinal nematodes of livestock date: 2012 words: 5434 flesch: 58 summary: Similar to A. afra, M. longifolia acetone extract at 2.5 mg/mL suppressed the hatching of nematode eggs with 26.1% but water extract at the highest concentration (7.5 mg/mL) inhibited less than 2% eggs from hatching (Table II). In vitro cultures were prepared from nematode eggs from microscopically positive faecal samples of sheep. keywords: acetone; afra; development; eggs; et al; extracts; larvae; longifolia; nda; nematodes; water cache: bjp-11437.pdf plain text: bjp-11437.txt item: #40 of 942 id: bjp-11499 author: Gurudeeban, Selvaraj; Satyavani, Kaliyamurthi; Ramanathan, Thirugnanasambandam title: Alpha-glucosidase inhibitory effect and enzyme kinetics of coastal medicinal plants date: 2012 words: 2457 flesch: 45 summary: Coastal medicinal plants also engage in recreation to treat diabetes, particularly where most people have limited resources and do not have access to modern treatment (Ramanathan, 2000). Therefore, in the present study we evaluated alpha glucosidase inhibitory effect of coastal medicinal plants on Saccharomyces cerevisiae -glucosidase to control postprandial hyperglycemia. keywords: colocynthis; enzyme; glucosidase; inhibitors; plants cache: bjp-11499.pdf plain text: bjp-11499.txt item: #41 of 942 id: bjp-11507 author: Rasul, Azhar; Song, Runmin; Wei, Wei; Nishino, Yoshikazu; Tsuji, Ichiro; Li, Xiaomeng; Li, Jiang title: Tubeimoside-1 inhibits growth via the induction of cell cycle arrest and apoptosis in human melanoma A375 cells date: 2012 words: 4640 flesch: 59 summary: The results indicated that TBMS1 induced growth inhibition of A375 cells, in addition to other type of cancer cells previously reported including A549 lung cancer cells (Zhang et al., 2011), HeLa cervi- cal cancer cells (Xu et al., 2009), and nasopharyngeal carcinoma CNE-2Z (Ma et al., 2008; Weng et al., 2003). Flow cytometric analysis demonstrated that TBMS1 markedly induced apoptosis of A375 cells and arrested cell cycle at G2/M phase in a dose- dependent manner. keywords: a375; a375 cells; apoptosis; bcl-2; cancer; cells; control; cycle; et al; human; melanoma; tbms1 cache: bjp-11507.pdf plain text: bjp-11507.txt item: #42 of 942 id: bjp-11625 author: Sundarasekar, Jeevandran; Sahgal, Geethaa; Subramaniam, Sreeramanan title: Anti-candida activity by Hymenocallis littoralis extracts for opportunistic oral and genital infection Candida albicans date: 2012 words: 3816 flesch: 55 summary: Various plant parts such as bulb, flower, anther, root, leaves and stem were tested against this opportunistic organism and found that the flower and anther were effective at 6.3 mg/mL. This is the first report on anti-candida activity of H. littoralis methanol extract. The methanol crude extract has anti-candida activity for tested concentration. keywords: activity; albicans; anti; candida; cell; extracts; littoralis; mic; plant cache: bjp-11625.pdf plain text: bjp-11625.txt item: #43 of 942 id: bjp-11636 author: Gurudeeban, Selvaraj; Satyavani, Kaliyamurthi; Ramanathan, Thirugnanasambandam; Ravikumar, Palanisamy title: Dipeptidyl peptidase IV inhibitors derived from a mangrove flora Rhizophora mucronata: An in silico approach date: 2012 words: 3926 flesch: 60 summary: For safety and cost effective measures, Diabetologist focussed their interest towards DPP IV inhibitor from potentially available medicinal plants through in silico approaches. To extend the incretin effect on enhanced insulin secretion, two approaches can be taken, the intravenous administration of GLP-1 or the oral admi- nistration of DPP IV inhibitors to slow down the other- wise rapid inactivation of endogenous GIP and GLP-1 (Mest and Mentlein, 2005). keywords: acid; bond; chain; cluster; docking; dpp; energy; figure; hydrogen; interaction; lig cache: bjp-11636.pdf plain text: bjp-11636.txt item: #44 of 942 id: bjp-11656 author: Fang, Meiyu; Wang, Shengye; Zheng, Yabing; Kong, Xiangmin; Gong, Liyan; Qiu, Youhao; Zhao, Yazhen; Mao, Weimin title: Maintenance therapy with oral etoposide following first-line docetaxel-cisplatin chemotherapy in metastatic non-small cell lung cancer patients date: 2012 words: 5116 flesch: 53 summary: Cisplatin and gemcitabine first-line chemotherapy followed by maintenance gemcitabine or best supportive care in advanced non-small cell lung cancer: A phase III trial. Treatment with docetaxel has been found to improve the long term survival of metastatic NSCLC patients; but the median survival is only about 4-5 months. keywords: cancer; cell; chemotherapy; cisplatin; disease; etoposide; lung; maintenance; nsclc; patients; response; therapy; treatment cache: bjp-11656.pdf plain text: bjp-11656.txt item: #45 of 942 id: bjp-11727 author: Yan, Feng; Zhang, Yan; Wang, Beibei title: Effects of polysaccharides from Cordyceps sinensis mycelium on physical fatigue in mice date: 2012 words: 3069 flesch: 59 summary: The polysaccharides from Cordyceps sinensis have been reported to exhibit a Abstract This study was designed to determine the effects of polysaccharides from Cordyceps sinensis mycelium (CSP) on physical fatigue in mice. A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2012; 7: 217-221 Journal homepage: www.banglajol.info; www.bdjpharmacol.com Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088 Effects of polysaccharides from Cordyceps sinensis mycelium on physical fatigue in mice Feng Yan1, Yan Zhang 2 and Beibei Wang1 1Department of Physical Education, University of International Business and Economics, Beijing 10029, China; 2Harbin Institute of Physical Education, Harbin 150008, China. keywords: blood; csp; effects; fatigue; glycogen; group; mice; sinensis cache: bjp-11727.pdf plain text: bjp-11727.txt item: #46 of 942 id: bjp-11888 author: Kan, Shi-Hai; Tang, Jing; Li, Du-Jun; Wang, Zhi-Qiang; Li, Chun-Xia; Huang, Fei title: Inhibition of the expression of a proliferation-induced ligand APRIL in HepG2 cell line and the reversal on tumor immune evasion by Chinese medicine date: 2012 words: 4250 flesch: 58 summary: As shown in Figure 1, HepG2 cells proliferation were inhibited after effected by ICA (A), BAI (B) combing ith ADM© for 48 hours, of which ICA 25 μg/mL, BAI 400, 200, 100 μg/mL, ADM 16, 8, 4, 2 μg/mL experimental groups inhibition of proliferation effect is obvious compared with untreated control group. Control ICA BAI ADM ICA + ADM BAI + ADM 24 hours 48 hours 72 hours 96 hours Figure 2: Influence of different time of ICA, BAI, ADM on HepG2 cells proliferation; keywords: adm; april; bai; cells; expression; hepg2; hepg2 cells; ica; proliferation; tumor cache: bjp-11888.pdf plain text: bjp-11888.txt item: #47 of 942 id: bjp-11908 author: Huang, Xiao-Hui; Xie, Hai-Tang; Kun, Wang; Huang, Ji-Han; Sun, Rui-Yuan title: Three-bottle exponential decay infusion: A novel intravenous infusion strategy for drugs which conform to three-compartment model with observations on propofol kinetics date: 2012 words: 5283 flesch: 65 summary: With this method, a specified steady- state plasma concentration can be rapidly obtained by combining three bottles in series with exponential decay of drug concentration. It should be also noted that, when applying this method, in the early phase of infusion the drug amount into the body is larger than that of CRI, and drug concentrations rise relatively quickly. keywords: bottle; compartment; concentration; drug; infusion; method; min; model; pharmacol; time cache: bjp-11908.pdf plain text: bjp-11908.txt item: #48 of 942 id: bjp-1195 author: Bandara, Thushari; Rokeya, Begum; Khan, Sakina; Ali, Liaquat; Ekanayake, Sagarika; Jansz, Errol R.; Balasubramanium, Kandiah title: Effects of Gymnema lactiferum leaves on glycemic and lipidemic status in type 2 diabetes subjects date: 2009 words: 2801 flesch: 61 summary: Further the chron- ic consumption of leaf powder produced a significant decline (p=0.004) in serum total cholesterol levels and serum LDL levels (p=0.023). The effect of G. lactiferum leaf powder on fasting se- rum glucose levels has been shown in Table II. keywords: day; group; lactiferum; leaf; levels; patients; powder; serum cache: bjp-1195.pdf plain text: bjp-1195.txt item: #49 of 942 id: bjp-1211 author: Ravi, Subban; Sadashiva, C. T.; Tamizmani, T.; Balasubramanian, T.; Rupeshkumar, M.; Balachandran, Indira title: In vitro glucose uptake by isolated rat hemidiaphragm study of Aegle marmelos Correa root date: 2008 words: 2972 flesch: 59 summary: Administration of A. marmelos fractions and insulin together was found to be less effective than A. marmelos fractions alone, but significantly higher than insulin treated group (p<0.001). Administration of A. marmelos fractions and insulin together was found to be less effective than A. marmelos fractions alone, but significantly higher than insulin treated group (p< 0.001). keywords: fractions; glucose; insulin; marmelos; uptake cache: bjp-1211.pdf plain text: bjp-1211.txt item: #50 of 942 id: bjp-12143 author: Chikku, Anitha M.; Rajamohan, Thankappan title: Dietary coconut sprout beneficially modulates cardiac damage induced by isoproterenol in rats date: 2012 words: 4301 flesch: 55 summary: But coconut sprout pretreated rats (Group IV, V and VI) showed lower activities of CK- MB, LDH, AST and ALT in the serum and higher activity in heart. Abstract This work evaluates the cardioprotective potential of dietary coconut sprout (Cocos nucifera Linn.) on isoproterenol induced myocardial infarction in rats. keywords: activity; coconut; control; group; heart; infarction; isoproterenol; protein; rats; sprout cache: bjp-12143.pdf plain text: bjp-12143.txt item: #51 of 942 id: bjp-12314 author: Madeswaran, Arumugam; Umamaheswari, Muthuswamy; Asokkumar, Kuppusamy; Sivashanmugam, Thirumalaisamy; Subhadradevi, Varadharajan; Jagannath, Puliyath title: In silico docking studies of aldose reductase inhibitory activity of commercially available flavonoids date: 2012 words: 3466 flesch: 55 summary: In silico docking study, was carried out to identify the inhibiting potential of selected flavonoids against aldose reductase enzyme. Figure 3: Docked pose of aldose reductase enzyme (3EL3) with butein and epalrestat Bangladesh J Pharmacol 2012; 7: 266-271 269 Based on the current docking studies, the aldose reductase inhibitory activity of the selected compounds was found to be decreased in the order of butein, biochanin, herbacetin, epalrestat, fisetin, esculatin. keywords: activity; aldose; compounds; docking; energy; enzyme; flavonoids; mol; reductase; studies cache: bjp-12314.pdf plain text: bjp-12314.txt item: #52 of 942 id: bjp-12351 author: Arshad, Usman; Janbaz, Khalid Hussain; Bashir, Samra; Rehman, Najeeb-ur; Mehmood, Malik Hassan; Gilani, Anwar Hassan title: Ethnopharmacological studies on Chrozophora prostrata in perspective of its folkloric reputation as purgative date: 2012 words: 3409 flesch: 51 summary: These data show that C. prostrata possesses laxative effect at low doses mediated through cholinergic action followed by the spasmolytic activity at high doses mediated possibly through K+ channel activation. The plant extract produced contractions in ileum preparations which were also blocked in the presence of atropine, thus confirming the presence of spasmogenic effect in C. prostrata mediated possibly through stimulation of cholinergic receptors, similar to ACh, which is known to have excitatory action on gut segments (Brown and Taylor, 2006). keywords: contractions; effect; pharmacol; prostrata cache: bjp-12351.pdf plain text: bjp-12351.txt item: #53 of 942 id: bjp-12497 author: Saravanan, Venkattapuram Sampath; Manokaran, Sellimuthu title: Physico-chemical studies and evaluation of diuretic activity of Cucurbita maxima date: 2012 words: 2511 flesch: 56 summary: Group I: Control group received 5 mL of 0.9% NaCl solution per kg body weight; Group II: Reference con- trol group received acetazolamide (45 mg/kg body weight in 5 mL of 0.9% NaCl solution); Group III: Test group received C. maxima extract (150 mg/kg body weight in 5 mL of 0.9% NaCl solution suspending in 1% carboxy methyl cellulose); Group IV: Test group recei- ved C. maxima extract (300 mg/kg body weight in 5 mL of 0.9% NaCl solution suspending in 1% carboxymethyl cellulose). Its aerial part consists of flexible succulent stem with trifoliate A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2012; 7: 277-280 Journal homepage: www.banglajol.info; www.bdjpharmacol.com Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088 Physico-chemical studies and evaluation of diuretic activity of Cucurbita maxima Venkattapuram Sampath Saravanan and Sellimuthu Manokaran Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode 638 112, Tamilnadu, India. keywords: activity; ash; extract; group; maxima cache: bjp-12497.pdf plain text: bjp-12497.txt item: #54 of 942 id: bjp-12499 author: Lee, Wei Cai; Mahmud, Roziahanim; Noordin, Rahmah; Piaru, Suthagar Pillai; Perumal, Shanmugapriya; Ismail, Sabariah title: Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa date: 2012 words: 3775 flesch: 61 summary: Both T. crispa and P. guajava crude extracts, 8 fractions from T. crispa crude extract and clindamycin (positive control used in anti-parasitic assay) were tested for the potential cytotoxic activity in vitro using Vero cells. According to Zirihi et al. (2005), an extract is considered safe when EC50 is >20 µg/mL. As shown in Table I, T. crispa extract and P. guajava extract as well as the eight fractions obtained from T. crispa crude extract and clindamycin (as positive control) showed no cytotoxicity against Vero cells. keywords: activity; alkaloids; cells; crispa; crude; ec50; extract; gondii; guajava cache: bjp-12499.pdf plain text: bjp-12499.txt item: #55 of 942 id: bjp-12725 author: Yi, Lei; Feng, Jianjun; Ji, Haiwang; Zhang, Xuechong title: Effect of Aralia chinensis on serum TNF-a, IL-4 and IL-10 level in rats with adjuvant-induced arthritis date: 2012 words: 2358 flesch: 52 summary: The remaining rats were divided randomly into 3 groups (n = 8 per group): Adjuvant arthritis group, T. wilfordii group and A. chinensis extract group. In the control and adjuvant arthritis groups, rats received intragastrically treatment with normal saline of equal volume once daily for 28 days. keywords: adjuvant; arthritis; chinensis; group; il-4; rats cache: bjp-12725.pdf plain text: bjp-12725.txt item: #56 of 942 id: bjp-12802 author: Khan, Muhammad; Qazi, Javed Iqbal; Rasul, Azhar; Zheng, Yongchen; Ma, Tonghui title: Evodiamine induces apoptosis in pancreatic carcinoma PANC-1 cells via NF-κB inhibition date: 2013 words: 4444 flesch: 52 summary: Furthermore, gemci- tabine is reported to up-regulate nuclear factor-κB (NF- κB) in pancreatic cancer cells which is associated with the development of drug resistance (Ou et al., 2010). It is well established that NF-κB constitutively expressed in pancreatic cancer cells. keywords: apoptosis; cancer; cells; evodiamine; panc-1; panc-1 cells; pancreatic; κbp65 cache: bjp-12802.pdf plain text: bjp-12802.txt item: #57 of 942 id: bjp-12806 author: Liu, Yanxia; Xu, Weiwei; Liu, Lei; Guo, Linming; Deng, Yu; Liu, Junkang title: N-acetyl glucosamine improves intestinal mucosal barrier function in rat date: 2012 words: 2935 flesch: 50 summary: Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. These results indicated that the intestinal permeability was improved following GlcNAc treatment, suggesting the improvement in intestinal mucosal barrier. keywords: acid; barrier; dao; glcnac; group; ibs; mucosal; rats cache: bjp-12806.pdf plain text: bjp-12806.txt item: #58 of 942 id: bjp-12847 author: Shen, Huimin; Li, Xiaomao; Yang, Yuebo; Wang, Xiaoyun; Zhang, Xu title: Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells date: 2013 words: 3956 flesch: 63 summary: HEC-1-A cells and JEC cells were treated with by lovastatin and the proportion of cells in G1 phase was detected. At 20 and 16 hours after G1-phase desynchronization, the proportion of cells in S phase reached a maximal level and that in G1 phase was at the minimal level for HEC-1-A cells and JEC cells, respectively. keywords: cells; hours; jec; lovastatin; phase; synchronization; μmol cache: bjp-12847.pdf plain text: bjp-12847.txt item: #59 of 942 id: bjp-12862 author: Ullah, Naveed; Khan, Mir Azam; Khan, Taous; Ahmad, Waqar title: Bioactive traditional plant Cinnamomum zeylanicum successfully combat against nephrotoxic effects of aminoglycosides date: 2013 words: 3984 flesch: 55 summary: The body weight of animals treated with both gentamicin and C. zeylanicum were found significantly different from group G animals, exactly same as group C (Figure 1A). (A) Percent loss in mean body weight in group G animals (gentamicin treated) significantly different from control group, extract treated group and animals treat- ed with both gentamicin and extract. keywords: animals; day; gentamicin; group; serum; zeylanicum cache: bjp-12862.pdf plain text: bjp-12862.txt item: #60 of 942 id: bjp-12873 author: Khan, Munasib; -Rehman, Najeeb-ur; Khan, Arif-ullah; Gilani, Anwar Hassan title: Pharmacological basis for the medicinal use of Morus alba in gut and airways disorders date: 2012 words: 6272 flesch: 55 summary: M. alba is used in folk medicine to treat diarrhea, asthma, cough, dyspepsia, eye problems, intestinal ul- cers, headaches, hemoptysis, hepatopathy, hoarseness, lumbago, melancholia, scabies, smallpox and spleno- pathy (Baquar, 1989; Brown, 1995; M. alba is reported to possess antidiabetic (Chen et al., 1995), anti-inflammatory (Hong et al., 2002; Choi and Hwang, 2005), hepatoprotective (Oh et al., 1999), anti- This work is licensed under a Creative Commons Attribution 3.0 License. keywords: alba; channel; contractions; effect; et al; extract; gilani; m. alba; medicinal; morus; pharmacol; use cache: bjp-12873.pdf plain text: bjp-12873.txt item: #61 of 942 id: bjp-12982 author: Mumtaz, Sayeed Mohammed Firdous; Paul, Shounak; Bag, Anupam Kanti title: Effect of Sechium edule on chemical induced kidney damage in experimental animals date: 2012 words: 4207 flesch: 48 summary: Total protein (mg/dL) Normal control 25.1 ± 2.0 17.0 ± 5.7 1.0 ± 0.0 6.8 ± 0.2 Potassium dichromate (15 g/kg) 61.2 ± 3.2a 28.6 ± 1.5a 2.1 ± 0.1a 3.0 ± 0.1a Aqueous extract (200 mg/kg) 37.0 ± 1.8b 17.3 ± 0.8b 1.3 ± 0.0b 5.2 ± 0.3b Aqueous extract (100 mg/kg) 52.2 ± 2.3 24.4 ± 1.1 2.0 ± 0.1b 4.2 ± 0.1b Values are expressed as mean ± SEM, n = 6; ap<0.001 considered statistically significant as compared to normal control group; bp<0.001 consid- ered statistically significant Table III Effect of aqueous extract of leaves of Sechium edule on biochemical parameters in streptozotocin-induced dia- betic nephropathy in mice Treatment design Blood urea (mg/dL) Blood urea nitrogen (mg/dL) Serum creatinine (mg/dL) So, in the present study the effect of aqueous extract of leaves of S. edule was investigated in chemical-induced kidney damage in experimental animals. keywords: blood; edule; extract; group; rats; sechium; serum; urea cache: bjp-12982.pdf plain text: bjp-12982.txt item: #62 of 942 id: bjp-13034 author: Ravi Kumar, Gundampati; Chandrasekaran, Sambamurthy; Jagannadham, Medicherla V. title: Molecular docking study on the interaction between trypanothione reductase and mangiferin for antileishmanial activity date: 2012 words: 2535 flesch: 48 summary: Protein preparation for docking The 3D structure of Leishmania Infantum Try R (PDB ID: 2jk6) was downloaded from Protein Data Bank (PDB) (http://www.pdb.org/pdb/home/home.do), before initiating the docking simulations, all non-protein mole- cules were removed from Try R (Figure 1); for any alternative atom locations only the first location was retained. For each ligand, a docking experiment consis- ting of 100 stimulations was performed and the analysis was based on binding free energies and root mean square deviation (RMSD) values, and the ligand mole- cules were then ranked in the order of increasing docking energies. keywords: autodock; docking; energy; mangiferin; reductase; try; trypanothione cache: bjp-13034.pdf plain text: bjp-13034.txt item: #63 of 942 id: bjp-13088 author: Khan, Amir Zada; Mohammad, Akhtar; Iqbal, Zafar; Anis, Itrat; Shah, Muhammad Raza; Nadeem, Said; Rabnawaz, Muhammad; Shahidullah, Adnan; Khan, Humayun; Khan, Inamullah title: Molecular docking of viscosine as a new lipoxygenase inhibitor isolated from Dodonaea viscosa date: 2012 words: 2096 flesch: 45 summary: They also play a significant role in cancer cell growth, metastasis, invasiveness, cell survival and induction of tumor necrosis factor (TNF) (Khan et al., 2009; 2011). Catalytic or active site of lipoxygenase is composed of 3 important amino acid residues the so- called catalytic triad (His523, His518, Ile875) along with iron atom (Khan et al., 2011). keywords: docking; hydrogen; interactions; khan; lipoxygenase; viscosine cache: bjp-13088.pdf plain text: bjp-13088.txt item: #64 of 942 id: bjp-13121 author: Misbahuddin, Mir; Bashar, Tahmina; Hossain, Md. Amir title: Effectiveness of garlic oil in the treatment of arsenical palmar keratosis date: 2013 words: 4408 flesch: 60 summary: Same number (20) of arsenic exposed controls (having no signs and symptoms of melanosis and/or keratosis) were selected from the family members of those patients. There were two males and 15 females from arsenic exposed controls. keywords: arsenic; bangladesh; controls; garlic; keratosis; oil; palmar; patients; study; treatment cache: bjp-13121.pdf plain text: bjp-13121.txt item: #65 of 942 id: bjp-13157 author: Rode, Mahesh S.; Kalaskar, Mohan G.; Gond, Namdev Y.; Surana, Sanjay J. title: Evaluation of anti-diarrheal activity of Diospyros malabarica bark extract date: 2013 words: 2779 flesch: 53 summary: Ba gladesh Jour al of Phar acology Research Article Evaluation of antiEvaluation of antiEvaluation of anti---diarrheal activity diarrheal activity diarrheal activity of of of Diospyros malabaricaDiospyros malabaricaDiospyros malabarica bark extractbark extractbark extract BJP Introduction Diarrhea is one of the major health threats to popula- tions in tropical and subtropical countries, responsible for about 5 million deaths annually, of which 2.5 million are children less than 5 years (Adeyemi and Akindele, 2008). Material and methods Bark of D. malabarica kostel was collected in bulk quan- tities from college campus area, Malegaon, Baramati in winter season of 2008-2009 and identification of the plant was established by Department of Botany, S. P. M. A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2013; 8: 49-53 Journal homepage: www.banglajol.info; www.bdjpharmacol.com Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088 Evaluation of anti-diarrheal activity of Diospyros malabarica bark extract Mahesh S. Rode1, Mohan G. Kalaskar2, Namdev Y. Gond1 and Sanjay J. Surana2 1SVPM’S College of Pharmacy, Malegoan, Baramati, Pune, India; 2R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, India. keywords: activity; diarrheal; extract; group; malabarica cache: bjp-13157.pdf plain text: bjp-13157.txt item: #66 of 942 id: bjp-13169 author: Li, Wei; Zhang, Zheng title: Implication of ermCX gene of Corynebacterium striatum in macrolide resistance in Beijing, China date: 2013 words: 2717 flesch: 48 summary: Abstract To study the resistance mechanism of Corynebacterium striatum clinical isolates to macrolide antibiotic, 57 strains of C. striatum clinical isolates were detected by susceptibility testing, PCR amplification and DNA sequencing. Among the 57 strains of C. striatum isolates, 9 strains with ermCX gene were screened out，the detection rate was 15.8% (9/57). keywords: azithromycin; ermcx; erythromycin; gene; macrolide; resistance; strains; striatum cache: bjp-13169.pdf plain text: bjp-13169.txt item: #67 of 942 id: bjp-13172 author: Saboo, Shweta S.; Tapadiya, Ganesh; Farooqui, I. A.; Khadabadi, S. S. title: Free radical scavenging, in vivo antioxidant and hepatoprotective activity of folk medicine Trichodesma sedgwickianum date: 2013 words: 4500 flesch: 52 summary: Anti-oxidant activity of different extracts was evaluated by free radical scavenging by ABTS and DPPH, super- oxide scavenging and lipid peroxide inhibition. Synergistic interactions amongst the various anti- oxidative components in the SEE of T. sedgwickianum might be responsible for the relatively high values of anti-oxidant activity. keywords: activity; anti; carbon; ethanol; extract; free; liver; oxidant; radical; scavenging; superoxide; tetrachloride; vivo cache: bjp-13172.pdf plain text: bjp-13172.txt item: #68 of 942 id: bjp-13174 author: Li, Qiang; Zhao, Xue-Ling; Sun, Juan; Jiang, Shou-Gang; Xianfeng, Gong title: Anti-proliferative and apoptosis-inducing activities of juglone in LS-174T cells date: 2013 words: 5336 flesch: 58 summary: Discussion Walnut has been used in traditional medicines for various ailments and some extracts of walnut are also 68 Bangladesh J Pharmacol 2013; 8: 65-72 &RQFHQWUDWLRQ���0� $ EV RU ED QF H �>$ �� � -� �@ ��� ��� ��� ��� � �������������������������������������������������������������������������������������������������������������������������������������������������������������� Figure 3B: Pro-apoptotic effect of juglone determined by ELISA quantification of DNA fragmentation expressed as optical density (OD) values LS-174T cells were incubated in the medium alone or in the medium containing 12.5,25,50 and 100 µM juglone for 36 hours (** and *** stands for p<0.01 and p<0.001 compared with 0 µM, respectively) D������������������E���������������F�����������������G����������������H������������������� GAPDH was used as an equal loading control &RQFHQWUDWLRQ���0� & DV S DV H -� �D FW LY LW\ � P �P J ���� ���� ���� ��� ��� ��� ��� � ��������������������������������������������������������������������������������������������������������������������������������������������������� Figure 4C: Caspase-3 activity of juglone-treated LS-174T cells The cells were treated with 0, 12, 25, 50, 100 μM juglone for 36 hours (**stands for p<0.01 compared with 0 µM) fragment of PARP was shown to be a hallmark of apoptosis. keywords: dqjodghvk �; evwudfwv �; h �; juglone; rqfhqwudwlrq �; � +duelq; � -rxuqdo; � .gd; � 8qlyhuvlw\; � dqg; � figure; � p0; � ri; � wkh; � zrun; � � cache: bjp-13174.pdf plain text: bjp-13174.txt item: #69 of 942 id: bjp-13183 author: Akhtar, Muhammad Shoaib; Mazher Asjad, Hafiz Muhammad; Bashir, Sajid; Malik, Abdul; Khalid, Rehan; Gulzar, Faisal; Irshad, Nadeem title: Evaluation of antioxidant and hepatoprotective effects of Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (KGA) date: 2013 words: 3251 flesch: 52 summary: Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate anti-oxidant activity. In vitro and in vivo studies of anti-oxidant activities of flavonoids from Adiantum capillus- veneris L. keywords: activity; anti; formulation; hepatoprotective; kga; liver; oxidant; serum cache: bjp-13183.pdf plain text: bjp-13183.txt item: #70 of 942 id: bjp-13337 author: Xu, Lantao title: Effect of antisense oligodeoxynucleotide targeting survivin on growth of human gastric cancer cells date: 2013 words: 3419 flesch: 59 summary: The sequence of ASODN was 5’- CCCAGCCTTCCAGCTCC TTG-3’and that of N-ODN $�-RXUQDO�RI�WKH�%DQJODGHVK�3KDUPDFRORJLFDO�6RFLHW\��%'36� %DQJODGHVK�-�3KDUPDFRO������������-�� -RXUQDO�KRPHSDJH��ZZZ�EDQJODMRO�LQIR��ZZZ�EGMSKDUPDFRO�FRP $EVWUDFWHG�LQGH[HG� LQ $FDGHPLF� 6HDUFK� &RPSOHWH� $JURIRUHVWU\� $EVWUDFWV�� $VLD� -RXUQDOV� 2QOLQH�� %DQJODGHVK� -RXUQDOV� 2QOLQH�� %LRORJLFDO� $EVWUDFWV�� %,26,6� 3UHYLHZV�� &$%� $EVWUDFWV�� &XUUHQW� $EVWUDFWV�� 'LUHFWRU\� RI� 2SHQ� $FFHVV� -RXUQDOV�� (0%$6(�([FHUSWD� 0HGLFD�� *RRJOH� 6FKRODU�� +,1$5,� �:+2��� ,QWHUQDWLRQDO�3KDUPDFHXWLFDO�$EVWUDFWV��2SHQ�--JDWH� 6FLHQFH�&LWDWLRQ�,QGH[�([SDQGHG��6&2386�DQG�6RFLDO�6FLHQFHV�&LWDWLRQ�,QGH[� ,661������-����� Effect of antisense oligodeoxynucleotide targeting survivin on growth of human gastric cancer cells /DQWDR�;X 'HSDUWPHQW�RI�*DVWURHQWHURORJ\��)HQJ[LDQ�'LVWULFW�&HQWUDO�+RVSLWDO��6KDQJKDL���������&KLQD� $EVWUDFW Our study investigated the effects of antisense oligodeoxynucleotide targeting survivin on human gastric cancer cells. Bangladesh J Pharmacol. 2013; 8: 73- 77.p 7KLV�ZRUN�LV�OLFHQVHG�XQGHU�D�&UHDWLYH�&RPPRQV�$WWULEXWLRQ�����/LFHQVH��0.05). keywords: effect; gastrodin; mice; pain; treatment; vincristine cache: bjp-16836.pdf plain text: bjp-16836.txt item: #134 of 942 id: bjp-16967 author: Ntsoelinyane, Polo-Ma-Abiele Hildah; Mashele, Samson title: Phytochemical screening, antibacterial and antioxidant activities of Asparagus laricinus leaf and stem extracts date: 2014 words: 3573 flesch: 53 summary: Our results indicate that, A. laricinus leaf extracts have potential antimicrobial and anti-oxidant activities. Therefore in the present study, A. laricinus stem and leaf were collected to study their antibacterial activities, anti-oxidant activities and to investigate their active compounds in order to discover resources for new lead structures. keywords: activity; anti; concentration; extracts; laricinus; leaf; stem cache: bjp-16967.pdf plain text: bjp-16967.txt item: #135 of 942 id: bjp-16989 author: Iqbal, Shahid Muhammad; Mushtaq, Aamir; Jabeen, Qaiser title: Antimicrobial, antioxidant and calcium channel blocking activities of Amberboa divaricata date: 2014 words: 5042 flesch: 54 summary: A 100 µL of crude plant extract (20 mg/mL) was added into first well. The MBC values for all three strains were same i.e. 5 mg/mL. Anti-oxidant capacity of A. divaricata crude extract was determined by calculating total phenolic contents, total anti-oxidant capacity and DPPH radical scavenging assay. keywords: activities; activity; anti; calcium; compounds; concentration; divaricata; extract; pharmacol; plant; solution; tissue cache: bjp-16989.pdf plain text: bjp-16989.txt item: #136 of 942 id: bjp-16990 author: Attia, Mohamed I.; Ghabbour, Hazem A.; Zakaria, Azza S.; Fun, Hoong-Kun title: In vitro anti-Candida activity and single crystal X-ray structure of ({(1E)-[3-(1H-imidazol-1-yl)-1-phenylpropylidene]amino}oxy)(4-nitrophenyl)methanone date: 2014 words: 3815 flesch: 61 summary: In vitro anti-Candida activity and single crystal X-ray structure of ({(1E)-[3-(1H-imidazol-1-yl)-1- phenylpropylidene]amino}oxy)(4- nitrophenyl)methanone BJP Introduction In recent years, the incidence of serious fungal infec- tions has significantly increased. Single crystal X-ray structure of the title compound 4 confirmed its assigned (E)-configuration. keywords: albicans; antifungal; candida; compound; crystal; fluconazole cache: bjp-16990.pdf plain text: bjp-16990.txt item: #137 of 942 id: bjp-16992 author: George, Sonia; Ramzeena, Mohammed Basheer; Ram, Sayee Vignesh; Selvaraj, Senthil Kumar; Rajan, Shinu; Ravi, Thengungal Kochupappy title: Design, docking, synthesis and anti-E. coli screening of novel thiadiazolo thiourea derivatives as possible inhibitors of Enoyl ACP reductase (FabI) enzyme date: 2014 words: 3424 flesch: 60 summary: No. Compound code Zone of inhibition (mm) 1 3a 22 2 3b 28 3 3c 22 4 3d 24 5 3e 20 6 3f 23 7 3g 21 8 3h 28 9 Ciprofloxacin 30 Figure 2: Snap shot representing the binding interactions of 3 hours binding with enoyl ACP reductase fab1 with the active residue GLY93 with two hydrogen bonds presence of IR absorption bands at 3262.134 and 1591.32 corresponded to NH and thiadiazolyl C=N respec- tively. To conclude with, the present research focussed on the design of enoyl ACP reductase inhibitors of E. coli has resulted in the development of novel thiourea linked 1,3,4-thiadiazole derivatives. keywords: activity; coli; enoyl; mhz; nmr; reductase; thiadiazole cache: bjp-16992.pdf plain text: bjp-16992.txt item: #138 of 942 id: bjp-17153 author: Mohan, Divya S.; Saraswathy, Mini; Kurup, Muraleedhara Kurup Gopala title: Attenuation of hyperglycemia and hyperlipidemia in high calorie fed/streptozotocin-treated rats by hydromethanolic extract of Padina tetrastromatica date: 2014 words: 4875 flesch: 52 summary: Treatment of diabetic rats with P. tetrastromatica extract significantly elevated the glycogen levels in respect to the diabetic control (Table I). Therefore, the present study was designed to investigate the anti-diabetic and hypolipide -mic effects of P. tetrastromatica extract in experimental diabetes mellitus. keywords: activity; body; control; diabetes; diabetic; extract; glucose; glycogen; rats; tetrastromatica cache: bjp-17153.pdf plain text: bjp-17153.txt item: #139 of 942 id: bjp-17167 author: Bashar, Tahmina; Misbahuddin, Mir; Hossain, Md. Amir title: A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmar arsenical keratosis patients date: 2014 words: 4292 flesch: 61 summary: Ebru U, Burak U, Yusuf S, Reyhan B, Arif K, Faruk TH, Emin M, Aydin K, Atilla II, Semsettin S, Kemal E. Cardio- protective effects of Nigella sativa oil on cyclosporine A- induced cardiotoxicity in rats. Hypoglycemic Effects of the volatile oil of Nigella sativa seeds. keywords: arsenic; arsenical; bangladesh; group; keratosis; nigella; palmar; patients; sativa; study; treatment cache: bjp-17167.pdf plain text: bjp-17167.txt item: #140 of 942 id: bjp-17168 author: Rashid, Nafisa; Misbahuddin, Mir; Choudhry, Zubaida Khatoon; Saleh, Ahmed Abu; Sattar, Abu Naser Ibne title: The colony count of Escherichia coli in the stool of palmar arsenical keratosis following probiotics supplementation date: 2014 words: 4140 flesch: 55 summary: The mean colony counts of E. coli in the stool of arsenic exposed controls and patients were reduced to 7.3 x 1011 and 3.2 x 1011 CFU/g respectively in comparison to healthy volunteers (11.1 x 1011 CFU/g). The mean arsenic level in stool of patients was 4.4 ± 1.3 µg/g, which was less than arsenic exposed controls (5.1 ± 1.2 µg/g). keywords: arsenic; bangladesh; coli; controls; patients; probiotics; stool; supplementation; volunteers cache: bjp-17168.pdf plain text: bjp-17168.txt item: #141 of 942 id: bjp-17301 author: Arunkumar, Mani; Suhashini, Karuppaiyan; Mahesh, Narayanan; Ravikumar, Raju title: Quorum quenching and antibacterial activity of silver nanoparticles synthesized from Sargassum polyphyllum date: 2014 words: 3937 flesch: 48 summary: Silver nanoparticles synthesis using seaweeds: 10 mL of aqueous extracts of S. polyphyllum (10 g sample in 100 mL distilled water) solution was added to 90 mL (1 mM silver nitrate, AR grade) to makeup final volume to 100 ml. Bangladesh Journal of Pharmacology Research Article Quorum quenching and antibacterial activity of silver nanoparticles synthe- sized from Sargassum polyphyllum BJP Introduction Biological synthesis of nanoparticles using marine seaweeds has received much attention because of their potential to synthesize nanoparticles of various size, shape and morphology. keywords: activity; aeruginosa; agnps; bacteria; marine; nanoparticles; polyphyllum; quorum; seaweed; silver; synthesis cache: bjp-17301.pdf plain text: bjp-17301.txt item: #142 of 942 id: bjp-17304 author: Selvaraj, Stalin; Palanisamy, Sampathkumar title: Investigations on the anti-diabetic potential of novel marine seaweed Sargassum longiotom against alloxan-induced diabetes mellitus: A pilot study date: 2014 words: 2996 flesch: 52 summary: After the treatment with S. longiotom extract, there is a significant reduction (p<0.001) in blood glucose when compared with the diabetic control group. After the treatment with S. longiotom extract, there was significant reduction of total blood glucose when compared with the diabetic control group. keywords: alloxan; cholesterol; control; diabetes; extract; longiotom; rats cache: bjp-17304.pdf plain text: bjp-17304.txt item: #143 of 942 id: bjp-17337 author: Mallhi, Tauqeer Hussain; Qadir, M. Imran; Khan, Yusra Habib; Ali, Muhammad title: Hepatoprotective activity of aqueous methanolic extract of Morus nigra against paracetamol-induced hepatotoxicity in mice date: 2014 words: 4620 flesch: 59 summary: The plant kingdom still holds many species containing substances of medicinal value which have yet to be discovered: large numbers of plants are constantly being screened for their possible pharmacological value particularly for their anti-inflammatory (Qadir, 2009), hypotensive (Qadir, 2010), hypoglycemic, amoebicidal, anti-fertility, cytotoxic, antibiotic (Amin et al., 2012), spasmolytic, bronchodilator (Janbaz et al., 2013), antioxidant (Janbaz et al., 2012) and hepatoprotective properties (Ahmad et al., 2012). Phar- macologically it has been reported that M. nigra is antioxidant (Ozgenet al., 2009), anti-nociceptive (Padil- haet al., 2009), anti-inflammatory (Padilhaet al., 2010), antidiabetic (Husseinzadehet al., 1999), antibacterial (Mazimbaet al., 2011), cardiac depressant (Malik et al., 2012), effective for maternal health (Volpetoet al., 2011), vermifuge and anti-cancer (Kumar and Chauhan, 2008). keywords: activity; aqueous; bangladesh; extract; hepatoprotective; methanolic; morus; nigra; paracetamol; pharmacol cache: bjp-17337.pdf plain text: bjp-17337.txt item: #144 of 942 id: bjp-17368 author: Chowdhury, Tarali title: Virtual screening of compounds derived from Garcinia pedunculata as an inhibitor of gamma hemolysin component A of Staphylococcus aureus date: 2014 words: 3013 flesch: 48 summary: Two cavities were found to be responsible for ligand interaction within the 70 Bangladesh J Pharmacol 2014; 9: 67-71 Table III Energy score and H-bond interactions of the ligands with the target protein Chain A of 2QK7.pdb Ligand MolDock Score(Kcal/mol) I Details of two active site cavities with target receptor protein used by the ligands for docking Cavity Volume (A°) keywords: aureus; binding; component; compounds; docking; gamma; hemolysin; ligand; protein cache: bjp-17368.pdf plain text: bjp-17368.txt item: #145 of 942 id: bjp-17410 author: Reddi, K. V. N. Rathnakar; Rajesh, Sivarathri Siva; Narendra, Kumara; Jangala, Swathi; Reddy, Puli Chandra Obul; Satya, Alapati Krishna; Sivaraman, Thirunavukkarasu; Sekhar, Akila Chandra title: In vitro anti-venom potential of various Jatropha extracts on neutralizing cytotoxic effect induced by phospholipase A2 of crude venom from Indian cobra (Naja naja) date: 2014 words: 3838 flesch: 51 summary: The hemolysis produced by the venom in the absence of Jatropha extracts was taken as 100% and the percentage of inhibition/activation by each Jatropha extract used in the present study against snake venom PLA2s was calculated as shown in the following calculations. Though Jatropha is used in local / folk medicine as antidote for snake bite, our observations indicate that all species of Jatropha and all parts of the plant cannot be taken granted as antidote as a few of them are capable of enhancing venom activity in terms of hemolysis and consequently may lead to lethal. keywords: extracts; inhibition; jatropha; leaf; naja; root; snake; stem +; venom cache: bjp-17410.pdf plain text: bjp-17410.txt item: #146 of 942 id: bjp-17452 author: Iliemene, Uju Dorothy; Atawodi, Sunday Ene-Ojo title: In vivo antioxidant and hepatoprotective effects of methanolic extract of dioclea reflexa seed in rats following acute or chronic liver injury date: 2014 words: 4017 flesch: 46 summary: 9: 112-117 115 A B Figure 1: Mean aminotransferases activities in serum following daily intraperitoneal administration of D. reflexa extract (2.5 mg/ kg) with 72 hourly injection of carbon tetrachloride (0.3 mL/kg) for 10 days (A); intoxicated with carbon tetrachloride (0.6 mL/kg) following three days pre-treatment with methanol extract of D. reflexa (5.0 mg/kg) (B) 116 Bangladesh J Pharmacol 2014; 9: 112-117 Figure 4: Mean serum, liver, kidney, and heart superoxide dismutase levels of rats following daily intraperitoneal administration of D. reflexa extract (2.5 mg/kg) with 72 hourly carbon tetrachloride intoxication (0.3 mL/kg) for 10 days (A); rats intoxicated with carbon tetrachloride (0.6 mL/kg) following three days pre-treatment with methanol extract of D. reflexa (5.0 mg/kg) (B) A B References Abei H. Catalase. keywords: anti; atawodi; carbon; extract; group; rats; reflexa; tetrachloride cache: bjp-17452.pdf plain text: bjp-17452.txt item: #147 of 942 id: bjp-17474 author: Narayanaswamy, Radhakrishnan; Wai, Lam Kok; Abas, Faridah; Ismail, Intan Safinar title: Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors date: 2014 words: 4006 flesch: 52 summary: To our knowledge, we are the first to report the binding of these 12 curcumin analogues with that of human neutrophil elastase structure even though various enzymes were known to bind to the parent compound (curcumin). In the present study, we aimed to dock 17 different ligands of curcumin analogues with that of human neutrophil elastase. keywords: 2,6; analogues; benzylidene; bis; compound; curcumin; cyclohexanone; docking; elastase; human; ligand; pentadiene-3 cache: bjp-17474.pdf plain text: bjp-17474.txt item: #148 of 942 id: bjp-17502 author: Madeswaran, Arumugam; Asokkumar, Kuppusamy; Umamaheswari, Muthuswamy; Sivashanmugam, Thirumalaisamy; Subhadradevi, Varadharajan; Jagannath, Puliyath title: Computational drug design of potential α-amylase inhibitors using some commercially available flavonoids date: 2014 words: 2864 flesch: 53 summary: Binding energy of the individual compounds were calculated using the following formula, Binding energy = A + B + C - D Analysis of the receptor/ligand complex models generated after successful docking of the flavonoids was based on the parameters such as hydrogen bond interactions, п – п interactions, binding energy, RMSD of active site residues and orientation of the docked compound within the active site (Madeswaran et al., 2012). keywords: amylase; autodock; binding; docking; energy; flavonoids; mol cache: bjp-17502.pdf plain text: bjp-17502.txt item: #149 of 942 id: bjp-17530 author: Lamula, S. Q. Njabulo; Ashafa, A. O. Tom title: Antimicrobial and cytotoxic potential of Dianthus basuticus used in Basotho traditional practice date: 2014 words: 5475 flesch: 53 summary: Glo- bally, plant extracts are investigated for their all inclu- sive antimicrobial activities; yet, the therapeutic poten- tials of many of these plants have not been scientifically evaluated and validated (Fagbemi et al., 2009; According to Meyer et al. (1982), if the LC50 of any drug including plant extract is less than 100 μg/mL such drug is considered cytotoxic. keywords: activity; bacteria; basuticus; ethanol; extracts; gram; mic; plant; strains; test; water cache: bjp-17530.pdf plain text: bjp-17530.txt item: #150 of 942 id: bjp-17535 author: Parida, Pratap; Kalita, Samhita; Yadav, R. N. S.; Shankar, Brajesh title: Homology modeling and docking studies of Plasmodium falciparum telomerase reverse transcriptase with berberine and some of its derivatives date: 2014 words: 4214 flesch: 54 summary: It is reported that berberine extract inhibited telomerase activity in a dose dependent manner over a range of 30- 300 μM. It indicated that P. falciparum telomerase might be a potential target for future malaria chemotherapy (Sriwilaijareon et al., 2002; Sharma et al., 2011; Dutta et al., 1962; Gardner et al., 2002; Singh et al., 2010). (Sriwilaijareon et al., 2002). keywords: activity; bangladesh; berberine; docking; energy; et al; falciparum; ligand; pftert; protein; sequence; structure; studies; telomerase cache: bjp-17535.pdf plain text: bjp-17535.txt item: #151 of 942 id: bjp-17540 author: Kazeem, Mutiu Idowu; Ogungbe, Semawon Mauton; Saibu, Gbemisola Morounke; Aboyade, Oluwaseyi Mayode title: In vitro study on the hypoglycemic potential of Nicotiana tabacum leaf extracts date: 2014 words: 4618 flesch: 53 summary: The results revealed that aqueous extract of the plant was most effective inhibitor of -amylase (IC50 5.7 mg/mL) while acetone extract exhibited the best inhibitory potential on - glucosidase (IC50 4.5 mg/mL). I The percentage yield of different extracts of N. tabacum leaf Extracts Initial weight (g) Final weight (g) % yield Acetone 32.9 6.1 18.6 Ethanol 33.6 3.3 9.9 Water 38.7 2.3 6.0 activities of the acetone, ethanolic and aqueous extracts of the plant investigated. keywords: -amylase; -glucosidase; acetone; diabetes; extract; inhibition; inhibitory; tabacum; water cache: bjp-17540.pdf plain text: bjp-17540.txt item: #152 of 942 id: bjp-17543 author: Murugesan, Deepa; Ponnusamy, Renuka Devi; Karur Gopalan, Dhanalakshmi title: Molecular docking study of active phytocompounds from the methanolic leaf extract of vitex negundo against cyclooxygenase-2 date: 2014 words: 4303 flesch: 53 summary: COX-2 enzyme protein structure A program to check the stereochemical quality of protein structures. keywords: 6cox_a; bond; cox-2; docking; energy; extract; glide; ligand; negundo; phytocompounds; protein; score; structure; vitex cache: bjp-17543.pdf plain text: bjp-17543.txt item: #153 of 942 id: bjp-17555 author: Bajpai, Vivek K.; Kang, Sun Chul title: Antimycotic potential of a diterpenoid taxoquinone against Candida species isolated from Metasequoia glyptostroboides date: 2014 words: 4231 flesch: 50 summary: 0 20 40 60 80 100 120 140 9 8 7 6 5 4 3 2 1 0 Time (min) C. parapsilosis KBN06P00060 C. parapsilosis KBN06P00060 (CT) V ia bl e co un ts (L og C FU /m L) 0 20 40 60 80 100 120 140 9 8 7 6 5 4 3 2 1 0 Time (min) C. parapsilosis KBN06P00055 C. parapsilosis KBN06P00055 (CT) V ia bl e co un ts (L og C FU /m L) 0 20 40 60 80 100 120 140 9 8 7 6 5 4 3 2 1 0 Time (min) Figure 4: Effect of taxoquinone on the viable counts of the tested clinical isolates of Candida species effective and alternative biological approach to develop new and novel types of antifungal agents for preventive treatment of serious fungal infections caused by pathogenic Candida species. Scanning electron microscopy Based on the susceptibility and MIC concentration, one of the clinical isolates of Candida species was selected for further elaborative study of scanning electron microscopy (SEM), to deter-mine the anticandidal effi- cacy of bioactive compound taxoquinone on the mor- phology of Candida parapsilosis KBN06P00060. keywords: candida; candida species; effect; isolates; kbn06p00060; parapsilosis; species; taxoquinone cache: bjp-17555.pdf plain text: bjp-17555.txt item: #154 of 942 id: bjp-17583 author: Parida, Pratap; Deka, Priyadarshini; Shankar, Brajesh; Yadav, R. N. S. title: In silico antigenic site evaluation and antiviral therapy against dengue serotypes date: 2014 words: 4454 flesch: 60 summary: The aim of this study was to examine the mutation in antigenic site of dengue virus and the antiviral action of mycophenolic acid (MPA) and ribavirin (RBV) on NS3 proteins DENV I-IV determining the best drug that can be most active against the virus from the binding ener- gy and the pocket which fits the drug. The accession No., sequence length, hits, positions, antigenic sites, anti- genic site length and the highest score were given in the Table I-IV. keywords: acid; bangladesh; dengue; denv; energy; ligands; ns3; polg_denv; protein; site; virus cache: bjp-17583.pdf plain text: bjp-17583.txt item: #155 of 942 id: bjp-17754 author: Ullah, Aftab; Ahmad, Mahmood title: Hepatoprotective activity of Chenopodium murale in carbon tetrachloride-induced hepatic damage in rabbits date: 2014 words: 3982 flesch: 53 summary: This reflects the protection of structural and functional integrity of carbon tetrachloride damaged liver cells. Serum SGOT, SGPT and alkaline phosphatase elevation reflect liver damage due to disintegration of cell membrane and necrosis. keywords: activity; carbon; control; damage; extract; group; hepatoprotective; liver; murale; tetrachloride cache: bjp-17754.pdf plain text: bjp-17754.txt item: #156 of 942 id: bjp-17759 author: Sridhar, Nimmakayala; Surya Kiran, Bondada V.V.S.; Sasidhar, Donthamsetti Tharaka; Kanthal, Lakshmi Kanta title: In vitro antimicrobial screening of methanolic extracts of Cleome chelidonii and Cleome gynandra date: 2014 words: 3983 flesch: 56 summary: The antimicrobial potency of plant extracts was assessed by their zone of inhibition and activity index values. Plant extracts were re-suspended in acetone (which has no activity against test microorganisms) to make 10 mg/mL final concentration and then two fold serially diluted. keywords: activity; chelidonii; extracts; gynandra; mic; pharmacol cache: bjp-17759.pdf plain text: bjp-17759.txt item: #157 of 942 id: bjp-17770 author: Qadir, M. Imran; Murad, Muhammad Sajid Al; Ali, Muhammad; Saleem, Mohammad; Farooqi, Ammad Ahmad title: Hepatoprotective effect of leaves of aqueous ethanol extract of Cestrum nocturnum against paracetamol-induced hepatotoxicity date: 2014 words: 2241 flesch: 56 summary: Many plants have been identified as hepatoprotective like Trianthema decandra (Balamurugan and Muthusamy, 2008), Coccu- lus hirsutus (Thakare et al., 2009), Carica papaya (Sadeque and Begum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Convolvulus arvensis (Ali et al., 2013), Dodonaea viscosa (Khan et al., 2013), Trichodesma sedgwickianum (Saboo et al., 2013), OfIpomoea staphylina (Bag and Mumtaz, 2013) and Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (Akhtar et al., 2013). Cestrum nocturnum (Family Solanaceae) commonly known as “Queen of Night” is used as anti-inflamma- tory, analgesic (Mazumder et al., 2010), antimicrobial (Khan et al., 2011), antiepileptic (Perez et al., 2008), anti- cancer (Zhong et al., 2008), insecticidal (Savchenko et al., 2000), local anesthetic (Zeng et al., 2002), and CNS depressant (Zeng et al., 2003). keywords: extract; hepatoprotective; nocturnum; paracetamol cache: bjp-17770.pdf plain text: bjp-17770.txt item: #158 of 942 id: bjp-17785 author: Saleem, Mohammad; Ahmed, Bilal; Qadir, Muhammad Imran; Mahrukh, .; Rafiq, Maria; Ahmad, Mobasher; Ahmad, Bashir title: Hepatoprotective effect of Chenopodium murale in mice date: 2014 words: 3143 flesch: 59 summary: The plants like Luminetzera racemosa (Gnanadesigan et al., 2011), Convolvulus arvensis (Ali et al., 2013), Hibiscus vitifolius (Sameul et al., 2012), Carica papaya (Sadeque and Begum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Cocculus hirsutus (Thakare et al., 2009), Convolvulus arvensis (Ali et al., 2013), Dodonaea viscosa (Khan et al., 2013), Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (Akhtar et al., 2013), OfIpomoea staphylina (Bag and Mumtaz, 2013), Suaeda fruticosa (Rehman et al., 2013), Trianthema decandra (Balamurugan and Muthusamy, 2008) and Trichodesma sedgwickianum (Saboo et al., 2013) showed hepatoprotective effect. The presence of flavonoids (Vijay and Padmaa, 2011), saponins, (Kumar et al., 2011) or triterpenoids (Kim et al., 2004) is believed to be hepato- protective. keywords: bangladesh; extract; hepatoprotective; liver; methanolic; murale cache: bjp-17785.pdf plain text: bjp-17785.txt item: #159 of 942 id: bjp-17825 author: Mohamadizadeh, Flora; Afkhami, Majid; Ehsanpour, Maryam; Bahri, Amir Houshang title: Screening for antibacterial, antifungal and cytotoxic agents in three hard coral species from Persian Gulf date: 2014 words: 3793 flesch: 52 summary: Materials and Methods Sampling and identification: Three species of hard corals were collected using SCUBA diving from Hendurabi Island (26°40' 44 N 53 °37' 29 E) in the Persian Gulf in 2011 at depths of 5-15 m. Each sample was cut into small pieces and then immediately frozen and main- tained at -20ºC Sessile Marine organisms such as holothurians, sea urchins and hard corals are therefore also susceptible to microbial invasion. keywords: activity; antibacterial; coral; extracts; gulf; marine; persian; species cache: bjp-17825.pdf plain text: bjp-17825.txt item: #160 of 942 id: bjp-17859 author: Saleem, Mohammad; Karim, Mahrukh; Qadir, Muhammad Imran; Ahmed, Bilal; Rafiq, Maria; Ahmad, Bashir title: In vitro antibacterial activity and phytochemical analysis of hexane extract of Vicia sativa date: 2014 words: 3007 flesch: 58 summary: Sample of plant extract (n-hexane) was prepared by adding small amount of extract in 5 mL distilled water, mix it well then 12 mL methanol was added in it, shake it well then stay for 5 min. 6 mL distilled water was added and again stay for 5 min. 10 mL of 15 M HCl was added to it and place this in digital drying oven for 2 hours. Rauha JP, Remes S, Heinonen M, Hopia A, Kahkonen M, Kujala T, Pihlaja K, Vuorela H, Vuorela P. Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. keywords: acid; activity; antibacterial; et al; extract; hexane; plant; sativa cache: bjp-17859.pdf plain text: bjp-17859.txt item: #161 of 942 id: bjp-18049 author: Qadir, M. Imran; Ali, Muhammad; Ali, Muhammad; Saleem, Mohammad; Hanif, Muhammad title: Hepatoprotective activity of aqueous methanolic extract of Viola odorata against paracetamol-induced liver injury in mice date: 2014 words: 2922 flesch: 61 summary: Many plants have been identified as hepatoprotective like Trianthema decandra (Balamurugan and Muthusamy, 2008), Cocculus hirsutus (Thakare et al., 2009), Carica papaya (Sadeque and Begum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Convolvulus arvensis (Ali et al., 2013), Dodonaea viscosa (Khan et al., 2013), Trichodesma sedgwickianum (Saboo et al., 2013), OfIpomoea staphylina (Bag and Mumtaz, 2013), Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (Akhtar et al., 2013) and Morus nigra (Mallhi et al., 2014). Flavonoids have been identified in V. odorata (Siddiqi et al., 2012) and they may have hepatoprotective activity (Ali et al., 2013). keywords: extract; hepatoprotective; odorata; paracetamol; qadir cache: bjp-18049.pdf plain text: bjp-18049.txt item: #162 of 942 id: bjp-18180 author: Nainwal, Lalit Mohan; Parida, Pratap; Das, Aparoop; Bairy, Parth Sarathi title: Design and docking of novel series of hybrid xanthones as anti-cancer agent to target human DNA topoisomerase 2-alpha date: 2014 words: 4905 flesch: 54 summary: Targeted protein topo II , has most potential active site where the ligand could bind and interact was already previously identified and reported. Targeting DNA topoisomerase II in cancer chemo- therapy. keywords: bangladesh; cancer; compounds; dna; docking; drug; energy; hybrid; protein; residues; structure; topoisomerase; xanthone; xm7 cache: bjp-18180.pdf plain text: bjp-18180.txt item: #163 of 942 id: bjp-1824 author: Velavan, Sivanandham; Selvarani, S.; Adhithan, A. title: Cardioprotective effect of Trichopus zeylanicus against myocardial ischemia induced by isoproterenol in rats date: 2009 words: 2824 flesch: 51 summary: Wister strain rats were pretreated with T. zeylanicus leaves (500 mg/kg body weight) for 28 days and then intoxicated with isoproterenol (20 mg/100 g, i.p. for 2 consecutive days). Earlier studies on T. zeylanicus in experimental animals have shown several pharmacological activities such as hepatoproctection, anti-ulcer activity, anti-fatigue, anti- inflammatory activity, antioxidant activity, aphrodisiac activity, anti-stress, enhancement of swimming perfor- mance and immunomodulation (Sharma et al., 1989; keywords: group; heart; isoproterenol; plasma; rats; zeylanicus cache: bjp-1824.pdf plain text: bjp-1824.txt item: #164 of 942 id: bjp-18270 author: Kolita, Bhaskor; Gogoi, Dhrubajyoti; Dutta, Partha Pratim; Bordoloi, Manobjyoti; Bezbaruah, Rajib Lochan title: Arabinosyl transferase inhibitor design against Mycobacterium tuberculosis using ligand based drug design approach date: 2014 words: 2785 flesch: 49 summary: Therefore to meet the present challenges for inhibition of M. tuberculosis arabinosyl transferase by these compounds would be a useful starting point to design better therapeutics of M. tuberculosis and in vitro experiment on compounds, viz. Herein, we have considered the structure of ethambutol as a starting point to screen active compound then ethambutol. keywords: compounds; docking; drug; ethambutol; h(1; ligand; o(8; receptor; transferase; tuberculosis cache: bjp-18270.pdf plain text: bjp-18270.txt item: #165 of 942 id: bjp-18329 author: Alamgeer, -; Nawaz, Mehwish; Ahmad, Taseer; Mushtaq, Muhammad Naveed; Batool, Asma title: Hepatoprotective activity of Thymus linearis against paracetamol and carbon tetrachloride-induced hepatotoxicity in albino mice date: 2014 words: 3704 flesch: 60 summary: Group 3 and 4 were treated daily 250 and 500 mg/kg of ether extract, while group 5 and 6 received 250 and 500 mg/kg of aqueous extract of T. linearis respectively for 4 days orally and on the 2nd and 3rd day CCl4 was given half an hour after the administration of extract dose. Treatment with T. linearis extracts restored the elevated values of liver enzymes near to normal level, which is a clear manifestation of antihepatotoxic effect of T. linearis extracts. keywords: activity; ether; extract; group; hepatoprotective; liver; paracetamol cache: bjp-18329.pdf plain text: bjp-18329.txt item: #166 of 942 id: bjp-18430 author: Sui, Xin; Sun, Zhizhong; An, Weiwei; Cheng, Kai; Jiang, Shougang; Xianfeng, Gong title: 2,4,3',4'-tetramethoxy-biphenyl induces apoptosis in MGC-803 cells through a mitochondrial/caspase pathway date: 2014 words: 5070 flesch: 55 summary: In addition, DNA fragmentation became obvious after 50, 100, 200, 400 µM TMBP treatment for 36 hours and 150 µM for 24, 36 hours on agarose gel electrophoresis (Figure 2C), which further confirmed TMBP may induce cell apoptosis. Bangladesh Journal of Pharmacology Research Article 2,4,3′,4′-tetramethoxy-biphenyl in- duces apoptosis in MGC-803 cells through a mitochondrial/caspase pathway BJP Introduction Gastric cancer is the fourth most common cancer, after lung, breast and colorectal cancer, and the second leading cause of cancer death worldwide. keywords: apoptosis; cancer; caspase-3; cells; compounds; death; figure; hours; mgc-803; mgc-803 cells; ome; tmbp cache: bjp-18430.pdf plain text: bjp-18430.txt item: #167 of 942 id: bjp-18483 author: Ramya, Mayavan Sivaprakasam; Sivasubramanian, Kanagasabapathy; Ravichandran, Samuthirapandian; Anbuchezhian, Ramasamy title: Screening of antimicrobial compound from the sea slug Armina babai date: 2014 words: 4071 flesch: 52 summary: The MIC of A. babai extracts were determined against the test pathogens by a standard agar dilution method. 200 100 >200 >200 >200 Pseudomonas sp >200 25 >200 200 200 P. aeruginosa 150 50 200 >200 100 S.paratyphi >200 200 200 >200 >200 S. typhi >200 150 >200 >200 200 S. aureus 150 200 >200 100 50 Vibrio cholerae >200 200 >200 200 100 *No bacterial growth in the negative control plate Figure 2: TLC profile of A. babai extracts Figure 3: Molecular determination of A. babai extracts (L1- Protein marker; L2- Extracts) babai was estimated as 21.4% of dry weight .The electrophoretic profiles obtained from the extracts displayed the largest protein concentration. keywords: + +; activity; babai; cm-1; extracts; inhibition; sea; zone cache: bjp-18483.pdf plain text: bjp-18483.txt item: #168 of 942 id: bjp-18488 author: Kingsley, Bino; Arun, K. P.; Selvaraj, Stalin; Pemiah, Brindha title: Stereospermum tetragonam as an antidiabetic agent by activating PPARγ and GLUT4 date: 2014 words: 2682 flesch: 57 summary: Determination of cell GLUT4 and PPAR gamma Cell lysate were made and the resultant supernatant was used for the estimation of GLUT4 and PPAR gamma expression levels using ELISA kit (Qiagen QY- 03235). Semple RK, Chatterjee VK, O'Rahilly S. PPAR gamma and human metabolic disease. keywords: bangladesh; gamma; glut4; pparγ; present; tetragonam cache: bjp-18488.pdf plain text: bjp-18488.txt item: #169 of 942 id: bjp-18537 author: Afreen, Swarmita; Rahman, Md. Sayedur title: Adherence to treatment guidelines in a university hospital: Exploration of facts and factors date: 2014 words: 4847 flesch: 51 summary: In spite of efforts to improve guideline adherence, success was very little due to different barriers (Lugtenberg et al., 2011). Audit and feedback and clinical practice guideline adherence: Making feedback actionable. keywords: adherence; asthma; bangladesh; departments; guideline; medicine; prescribers; study; treatment cache: bjp-18537.pdf plain text: bjp-18537.txt item: #170 of 942 id: bjp-18555 author: ul Qamar, Muhammad Tahir; Mumtaz, Arooj; Ashfaq, Usman Ali; Adeel, Muhammad Muzammal; Fatima, Tabeer title: Potential of plant alkaloids as dengue NS3 protease inhibitors: Molecular docking and simulation approach date: 2014 words: 3015 flesch: 51 summary: Like other flaviviruses Dengue virus NS3 protease has been declared as significant drug target. Potential of plant alkaloids as dengue NS3 protease inhibitors: keywords: alkaloids; dengue; docking; drug; ns2b; ns3; ns3 protease; potential; protease; virus cache: bjp-18555.pdf plain text: bjp-18555.txt item: #171 of 942 id: bjp-18556 author: Saadullah, Malik; Chaudary, Bashir Ahmad; Uzair, Muhammad; Afzal, Khurram title: Antidiabetic potential of Conocarpus lancifolius date: 2014 words: 4265 flesch: 58 summary: Present Saponins Present Flavonoids Present Tannins Present Table II Inhibitory effects of C. lancifolius on α-glucosidase Concentration (mg/mL) % Inhibition 0.5 99.1 0.25 98.7 0.125 99.8 0.0625 98.9 0.03125 98.1 0.0156 99.1 0.0078 99.0 0.0039 98.5 Table III Effect of C. lancifolius extract on blood glucose level in alloxan induced diabetic rabbits No. of days Glucose level Control Diabetic Diabetic with Extract (100 mg/kg) Extract (200 mg/kg) Diamicran (80 mg/kg) 0 93.0 (5.1) 270.4 (3.3) 270.0 (5.4) 269.0 (4.7) 272.0 (5.9) 7 91.0 (4.3) 268.2 (4.1) 155.0 (5.1) 144.5 (5.5) Number of rabbits in each group = 6; Values are expressed as mean and SD within the parenthesis Bangladesh J Pharmacol 2014; 9: 244-249 247 Table IV Effect of C. lancifolius extract on total cholesterol and triglycerides level in alloxan-induced diabetic rabbits keywords: alloxan; bangladesh; diabetes; diabetic; effect; extract; lancifolius; pharmacol; rabbits cache: bjp-18556.pdf plain text: bjp-18556.txt item: #172 of 942 id: bjp-18593 author: Lin, Cheng-He; Xu, Hua-Li; Sun, Wei-Lun; Li, Feng; Lin, Guang-Zhu title: Equisetum sylvaticum base reduces atherosclerosis risk factors in rats fed a high-fat diet date: 2014 words: 3155 flesch: 56 summary: Model indicates high-fat diet group; 10, 20 and 40 mg/kg indicate ESA level. Sixty rats were randomly divided into six groups with 10 rats in each group: Normal group (fed with normal diet), model group (fed with high-fat diet), ESA groups (fed with high-fat diet and ESA at 10, 20 and 40 mg/kg body weight) and lovastatin group (fed with high-fat diet and lovastatin at 2.5 mg/kg body weight) as a positive control. keywords: cholesterol; diet; effects; esa; fat; group; levels; lipid; rats; serum cache: bjp-18593.pdf plain text: bjp-18593.txt item: #173 of 942 id: bjp-18602 author: Shah, Nabi; Shah, Abdul Jabbar; Ahmed, Manzoor; Gilani, Anwar Hassan title: Functional nature of the spasmolytic effect, phytochemical composition and acute toxicity studies on Sauromatum guttatum date: 2014 words: 3095 flesch: 55 summary: Crude extract of S. guttatum was then added in a cumulative fashion, where it caused a dose-dependent relaxation of the induced contraction with EC-50 value of 1.2 mg/mL (0.8-1.6) suggesting inhibitory effect on calcium entry (Figure 2A). The rightward displacement may be attributed to the presence of phytochemicals like alkaloids and tannins as these types of compounds in medicinal plants has been shown to have calcium entry blocking activity (Kai et al., 1998; Hwang et al., 2001). keywords: ca++; crude; effect; extract; guttatum; pharmacol cache: bjp-18602.pdf plain text: bjp-18602.txt item: #174 of 942 id: bjp-18610 author: Yakubu, Musa T.; Ogunro, Olalekan B. title: Effects of aqueous extract of Fadogia agrestis stem in alloxan-induced diabetic rats date: 2014 words: 5596 flesch: 54 summary: References Abdel-Moneim A, El-Feki M, Salh E. Effect of Nigella sativa, fish and glicazide on alloxan diabetic rats. Antidiabetic activities of aqueous leaves extract of Leonotis leonurus in streptozo- tocin induced diabetic rats. keywords: agrestis; alloxan; animals; blood; body; diabetic; et al; extract; glucose; rats; stem; weight cache: bjp-18610.pdf plain text: bjp-18610.txt item: #175 of 942 id: bjp-18831 author: Rahman, Md. Sayedur; Huda, Sharmila title: Antimicrobial resistance and related issues: An overview of Bangladesh situation date: 2014 words: 3605 flesch: 41 summary: Against this background, attempt has been taken, to overview the status of antimicrobial resistance and rela- ted contributory issues in Bangladesh. The present study was designed to understand Bangladesh situation about antimicrobial resistance. keywords: antimicrobial; bangladesh; health; issues; medical; pharmacol; questions; rahman; resistance cache: bjp-18831.pdf plain text: bjp-18831.txt item: #176 of 942 id: bjp-18874 author: Saleem, Mohammad; Ahmed, Bilal; Karim, Mahrukh; Ahmed, Shahzad; Ahmad, Mobasher; Qadir, M. Imran; Syed, Nawazish-i-Husain title: Hepatoprotective effect of aqeous methanolic extract of Rumex dentatus in paracetamol induced hepatotoxicity in mice date: 2014 words: 4021 flesch: 60 summary: It has been seen that many herbal plants are found to be hepatoprotective such as Cichorium intybus (Heibatollah et al., 2008), Luminet racemosa (Gnanadesigan et al., 2011), Solanum nigrum (Raju et al., 2003), Hibiscus vitifolius (Samuel et al., 2012), Chenopodium murale (Saleem et al., 2014), Trichodesma sedgwickianum (Saboo et al., 2013), Oflpomoea staphylina (Bag and Mumtaz, 2013), Convolvulus arvensis (Ali et al., 2013), Suaeda fruticosa (Rehman et al., 2013) and Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (Akhtar et al., 2013). It has antifungal, antibacterial, insecticidal and allelopathic activities (Hussain et al., 2010; Umer et al., 2010). keywords: bangladesh; dentatus; et al; extract; hepatoprotective; liver; methanolic; paracetamol; pharmacol cache: bjp-18874.pdf plain text: bjp-18874.txt item: #177 of 942 id: bjp-18875 author: Heidari Soureshjani, Ehsan; Heidari, Mina title: In vitro variation in antibacterial activity plant extracts on Glaucium elegans and saffron (Crocus sativus) date: 2014 words: 2480 flesch: 54 summary: d ia m et er a re a (m m ) 25 20 15 10 5 0 µg/disc 250 µg/disc 750 µg/disc 1500 Concentration of vegetal extracts 2 0 0 1 10 18 12 12 9 13 13 23 22 21 E. coil Proteus Staphylococcus aureus Salmonella enteritidis Bacillus anthracis Figure 1: Antimicrobial activity extract of G. elegans divaricata. The tests for antibacterial effect establish of vegetal extracts revealed that most of the extracts are representing an important source of substances with antimicrobial activity. keywords: activity; antimicrobial; bangladesh; disc; elegans; extracts; saffron cache: bjp-18875.pdf plain text: bjp-18875.txt item: #178 of 942 id: bjp-18894 author: Varun, G.; Lokesh, M.; Sandeep, M.; Shahbazi, Sajad; Gade, Deepak Reddy title: Novel indole derivatives as hepatitis C virus NS5B polymerase inhibitors: Pharmacophore modeling and 3D QSAR studies date: 2014 words: 3185 flesch: 54 summary: In the present investigation we focused on the identification and elucidation of common pharmacophore model from the previously published series of Indole deriva- tives which are having significant inhibitory profile over HCV NS5B (Kevin et al., 2011). The in vitro biological activity data was A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2014; 9: 290-297 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088 keywords: hepatitis; ligands; pharmacophore; pic50; polymerase; qsar; set; training cache: bjp-18894.pdf plain text: bjp-18894.txt item: #179 of 942 id: bjp-18897 author: Gogoi, Dhrubajyoti; Dutta, Prafulla; Yadav, R. N. S. title: 3D QSAR modeling of 4-nerolidylcatechol derivatives and virtual screening for identification of potent plasmodium inhibitor date: 2014 words: 3300 flesch: 53 summary: In this present investigation, a Partial Least-Squares (PLS) based 3D QSAR model on the 4-nerolidylcatechol derivatives was built and used for the identification of novel antimalarial compounds in the cheminformatics database (library). In rational drug design methodology, QSAR plays pivotal role in the prediction of unknown compounds for their potency as optimized candidate lead (Dearden, 2003; Scholz et al., 2013). keywords: compounds; derivatives; model; n o; nerolidylcatechol; qsar; set cache: bjp-18897.pdf plain text: bjp-18897.txt item: #180 of 942 id: bjp-18915 author: Selvaraj, Gurudeeban; Kaliamurthi, Satyavani; Thirugnanasambandam, Ramanathan title: Molecular docking studies on potential PPAR-γ agonist from Rhizophora apiculata date: 2014 words: 2912 flesch: 50 summary: 17.9 23.7 Figure 1: Molecular interaction of PPAR- with R. apiculata derived ligands. (A) Secondary structure of PPAR- ; (B) Interaction with acetamide, N-(4-methylphenyl)-; (C) Interaction with 4-butyl pyridine, 1-oxide; (D) Interaction with clivorine; (E) Interaction with p-aminodiethylaniline; (F) Interaction with thiazolidinediones; Green balls indicates hydrogen bonds A B C D E F Author Info Gurudeeban Selvaraj (Principal contact) e-mail: gurudeeb99@gmail.com Procheck and from the Ramachandran plot it was inferred that the modelled protein contain 80.3% of amino acid residues in the most favoured region, 5.2% in additional allowed region, 1.8% in general allowed region and only 2.7% of amino acid residues in disallowed region. keywords: acid; apiculata; compounds; interaction; ppar; protein; rhizophora cache: bjp-18915.pdf plain text: bjp-18915.txt item: #181 of 942 id: bjp-18965 author: Sivakumar, Dakshinamurthy; Hari, Natarajan; Sivaraman, Thirunavukkarasu title: Computational analyses on delineating specificity of 2-hydroxy-3,5-dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins date: 2014 words: 3451 flesch: 51 summary: Bangladesh Journal of Pharmacology Research Article Computational analyses on delineat- ing specificity of 2-hydroxy-3,5- dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins BJP Introduction Apoptosis is tightly regulated by intrinsic pathway activated by Bcl-2 family proteins present in the mitochondrial membrane and anti-apoptotic proteins of the Bcl-2 family are important cancer biomarkers as they are over expressed in all types of cancers (Kelly and Strasser, 2011). Therefore, administration of anti-cancer drugs interacting with anti-apoptotic proteins exhibiting no over expression may presumably cause some adverse effect (such as lymphopenia, thrombocytopaenia and anemia) to cancer patients. keywords: bcl; bcl-2; bh3; grooves; hdnb; mcl-1; proteins; sivaraman cache: bjp-18965.pdf plain text: bjp-18965.txt item: #182 of 942 id: bjp-19026 author: Bajpai, Vivek K.; Kang, Sun Chul title: A diterpenoid sugiol from Metasequoia glyptostroboides with α-glucosidase and tyrosinase inhibitory potential date: 2014 words: 3193 flesch: 50 summary: These findings confirm the therapeutic potential of diterpenoid compound sugiol from M. glyptostroboides as a novel candidate for using in food and medicine industry which may have practical potential to cure skin and diabetes mellitus type-2 related disorders. The inhibitiory effect of diterpenoid compound sugiol on the tyrosinase using a mushroom tyrosinase is demonstrated in Figure 3. keywords: activity; compound; et al; glucosidase; glyptostroboides; inhibitory; sugiol; tyrosinase cache: bjp-19026.pdf plain text: bjp-19026.txt item: #183 of 942 id: bjp-19065 author: Zhou, Wei; Cai, Jun-Feng; Yuan, Feng; Ma, Min; Yin, Feng title: In silico targeting of interleukin-6 by natural compounds date: 2014 words: 3154 flesch: 61 summary: Our work is looking into finding lead compound of natural origin against IL-6, an important cyto- kine having a profound role in pathogenesis of rheumatoid arthritis. In silico targeting of interleukin-6 by natural compounds. keywords: arg179; arthritis; compounds; drug; energy; hydrogen; il-6; lead; rheumatoid cache: bjp-19065.pdf plain text: bjp-19065.txt item: #184 of 942 id: bjp-19068 author: Hussain, Liaqat; Akash, Muhammad Sajid Hamid; Tahir, Madeha; Rehman, Kanwal; Ahmed, Khwaja Zafar title: Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice date: 2014 words: 4164 flesch: 59 summary: Aqueous methanolic extract of A. rosea were given orally for 7 consecutive days followed by daily toxic dose of acetaminophen. At the end of treatment period, evaluation of hepatoprotective activity of A. rosea was done on basis of levels of liver enzyme markers (aminotransferases, alkaline phosphatase and bilirubin) and histopathological examination of liver tissues. keywords: animals; bangladesh; group; hepatoprotective; levels; liver; pharmacol; rosea cache: bjp-19068.pdf plain text: bjp-19068.txt item: #185 of 942 id: bjp-19090 author: Khan, Munasib; Khan, Arif-ullah; Rehman, Najeeb-ur; Gilani, Anwarul-Hassan title: Cardiovascular inhibitory properties of Lens culinaris date: 2014 words: 2320 flesch: 52 summary: These data indicate that L. culinaris exhibits blood pressure lowering potential, mediated possibly through Ca++ channel blockade mechanism. In isolated rat aortic tissues, L. culinaris extract was screened against high K+ and phenylephrine- induced contractions. keywords: blood; contractions; culinaris; gilani; khan; pharmacol; pressure cache: bjp-19090.pdf plain text: bjp-19090.txt item: #186 of 942 id: bjp-19105 author: Mallhi, Tauqeer Hussain; Abbas, Khizar; Ali, Muhammad; Qadir, Muhammad Imran; Saleem, Mohammad; Khan, Yusra Habib title: Hepatoprotective activity of methanolic extract of Malva parviflora against paracetamol-induced hepatotoxicity in mice date: 2014 words: 3012 flesch: 59 summary: Many plants have been identified as hepatoprotective like Trianthema decandra (Balamurugan and Muthu- samy, 2008), Cocculus hirsutus (Thakare et al., 2009), Carica papaya (Sadeque and Begum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Convolvulus arvensis (Ali et al., 2013), Dodonaea viscosa (Khan et al., 2013), Trichodesma sedgwickianum (Saboo et al., 2013), OfIpo- moea staphylina (Bag and Mumtaz, 2013), Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (Akhtar et al., 2013), Cestrum nocturnum (Qadir et al., 2014a), Viola odorata (Qadir et al., 2014b), Chenopodium murale (Saleem et al., 2014) and Morus nigra (Mallhi et al., 2014). At the 8th day, blood samples were collected to estimate ALT, AST, ALP and total bilirubin; and livers from animals were separated for histo- pathological examination (Ali et al., 2013). keywords: activity; extract; hepatoprotective; parviflora; qadir cache: bjp-19105.pdf plain text: bjp-19105.txt item: #187 of 942 id: bjp-19132 author: Dutta, Satyajit; Kumar, Deepak; Mishra, Anand Kumar; Ray, Supratim; Nagarajan, K. title: Design, docking, synthesis and anticancer activity of some novel 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives date: 2014 words: 5910 flesch: 63 summary: Docking results of the drug and its derivatives via Arguslab docking software reveals that the e-value of glutamic acid compound 5a (-10.370504) is better as compared to that of the other glutamic acid analogs. Docking simulations The docking analysis of glutamic acid analogs, histone deacetylase protein and all the analogs with histone deacetylase protein was carried by Argus lab docking software. keywords: 0.0a; 2-(4; acid; c6h4; cancer; compounds; str cache: bjp-19132.pdf plain text: bjp-19132.txt item: #188 of 942 id: bjp-19342 author: Shafiq, Yousra; Naqvi, Baqir Shyum; Rizwani, Ghazala H.; Usman, Muhammed; Shah, Barkat Ali; Aslam, Muhammad; Hina, Bushra title: Anti-acne activity of Casuarina equisetifolia bark extract: A randomized clinical trial date: 2014 words: 3459 flesch: 57 summary: Exclusion criteria include a) patients with any mental and physical insufficiencies, genetic and endocrine disorders and other systemic illness, b) breast feeding mothers and pregnant women, c) acne patients except acne vulgaris (acne fulminans, acne rosaceous, acne necrotic), d) patients under 17 and above 34 years of age, e) patients who took any anti acne medication like isotretinoic acid, clindamycin gel or any oral antibiotic for acne treatment in last two months or any hormonal preparations, e.g. oral contraceptive pills. Effects of benzoyl peroxide and erythromycin alone and in combination against antibiotic-sensitive and -resistant skin bacteria from acne patients. keywords: acne; cream; equisetifolia; extract; grade; grading; group; patients; study cache: bjp-19342.pdf plain text: bjp-19342.txt item: #189 of 942 id: bjp-19437 author: Haznedaroglu, M. Zeki; Gokce, Goksel title: Zostera noltii extract lowers blood glucose and restores vascular function in diabetic rats date: 2014 words: 6375 flesch: 57 summary: Table I Effects of Z. noltii extract (single dose) on serum glucose levels in alloxan-induced diabetic rats Group Serum glucose (mg/dL) Treatment (mg/kg) 0 hour 2 hour 4 hour 6 hour 8 hour I Normal 71.7 ± 6.8 68.4 ± 7.1 65.2 ± 8.1 68.6 ± 8.3 70.3 ± 8.1 II Control (alloxan) 269.1 ± 11.7a 275.3 ± 10.9a 278.2 ± 12.1a 274.3 ± 9.2a 268.6 ± 8.8a III Z. noltii extract (50) 262.6 ± 10.8 265.6 ± 9.8 259.4 ± 9.7 256.4 ± 11.1 253.7 ± 9.9 IV Z. noltii extract (150) 259.3 ± 9.7 254.2 ± 9.3 238.6 ± 8.8 206.1 ± 10.4b 215.4 ± 10.2c V Z. noltii extract (250) 255.1 ± 12.1 243.1 ± 11.1 231.7 ± 9.1 192.4 ± 9.6b 199.5 ± 9.7b Serum glucose levels were obtained from fasted rats on the 3rd day after alloxan administration. In the single dose study, effects of Z. noltii extract on blood glucose levels were evaluated on the 3rd day after alloxan administration. keywords: alloxan; anti; control; diabetes; diabetic; effects; extract; glucose; group; levels; noltii; noltii extract; rats; z. noltii cache: bjp-19437.pdf plain text: bjp-19437.txt item: #190 of 942 id: bjp-19454 author: Banna, Quazi Rubyath; Parveen, Feroza; Iqbal, Md. Jalaluddin title: Growth inhibitory effect of ethanolic neem leaves extract on Klebsiella, Salmonella and Staphylococcus aureus date: 2014 words: 3082 flesch: 54 summary: Phytochemical studies and screening of leaf extracts of Azadirachta indica for its anti-microbial activity against dental pathogens. Antimicrobial activity in leaf extract of neem (Azadirachta indica Linn.). keywords: aureus; extract; growth; klebsiella; neem; salmonella cache: bjp-19454.pdf plain text: bjp-19454.txt item: #191 of 942 id: bjp-19483 author: Zhang, Yue; Quan, Ren-Fu; Cheng, Wei-Shan; Ye, Zhao-Ming; Li, Wei-Xu; Yang, Di-Sheng title: Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway date: 2014 words: 4045 flesch: 53 summary: However, the molecular mechanism of cell apoptosis induced by resibufogenin remains elusive. Briefly, cells were seeded in 6-well plates at a density of 2 × 105 cells per well and exposed to resibufogenin (0.0-40.0 nM) for 24 hours. keywords: apoptosis; cells; china; figure; hours; mg-63; osteosarcoma; resibufogenin; toad cache: bjp-19483.pdf plain text: bjp-19483.txt item: #192 of 942 id: bjp-19488 author: Ferdoush, Jannatul; Misbahuddin, Mir title: Effect of ethanol extract of leaves of Azadirachta indica on palmar arsenical keratosis: A single-blind trial date: 2014 words: 3627 flesch: 57 summary: Arsenical keratosis usually appears on palm and planter aspect of the feet and may also develop on the dorsum of the extremities and trunk (Caussy, 2005). Arsenical keratosis can be treated by either topical administration of drug or oral administration of dietary supplement or both. keywords: acid; arsenic; bangladesh; indica; keratosis; palmar; patients; salicylic; study; treatment cache: bjp-19488.pdf plain text: bjp-19488.txt item: #193 of 942 id: bjp-19489 author: Kumar, Arthanari Saravana; Ganesh, Mani; Peng, Mei Mei; Hyun Tae, Jang title: Phytochemical, antioxidant, antiviral and cytotoxic evaluation of Opuntia dillenii flowers date: 2014 words: 3146 flesch: 55 summary: Brand-Williams W, Cuvelier ME, Berset C. Use of free radical method to evaluate anti-oxidant activity, LWT- Food Sci Tech. 1995; 28: 25-30. In anti-oxidant assay, the DPPH assay exhibited potent anti-oxidant abilities with IC50 of 58.7 µg/mL. keywords: + +; activity; anti; cells; dillenii; extract cache: bjp-19489.pdf plain text: bjp-19489.txt item: #194 of 942 id: bjp-19567 author: Niu, Fu-Wen; Zhang, Yong-Jie; Li, Kun; Zhang, Mao-Shu title: Nobiletin acts as a potential anticancer agent against osteosarcoma by regulating ERK and AKT signaling pathways date: 2014 words: 4794 flesch: 49 summary: Upon exposure, nobiletin showed significant cell inhibitory effect on SaOS-2 cells in a dose-dependent manner as evidenced by MTT assay and LDH assay. Moreover, flow cytometric analysis demonstrated that upon treatment with nobiletin, SaOS-2 cells underwent apoptosis and showed increased number of cells arrested in G2/M phase. keywords: akt; anti; apoptosis; assay; cancer; cells; effect; erk; figure; hours; nobiletin; osteosarcoma; pathway; signaling; treatment cache: bjp-19567.pdf plain text: bjp-19567.txt item: #195 of 942 id: bjp-19568 author: Chen, Yang; Han, Xiang-Zhen; Wang, Wei; Zhao, Ren-Tao; Li, Xiao title: Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling date: 2014 words: 4025 flesch: 54 summary: Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signaling Yang Chen, Xiang Zhen Han, Wei Wang, Ren Tao Zhao and Xiao Li Department of Bone Tumor, Linyi People’s Hospital, Shandong 276 003, China. Our data showed that treatment of osteosarcoma cells with withaferin A beyond 30 µM at 24, 48 and 72 hours resulted in statistically significant toxicities and hence the maxi- mum concentration employed in subsequent studies was limited to 20 µM (Figure 1). keywords: cancer; cells; cycle; hours; mg-63; notch-1; osteosarcoma; treatment; u2os; withaferin cache: bjp-19568.pdf plain text: bjp-19568.txt item: #196 of 942 id: bjp-19704 author: Kamalakannan, K.; Balakrishnan, Veluchamy title: Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Limonia elephantum leaves date: 2014 words: 4262 flesch: 58 summary: The results of the present studies strongly indicate that the higher dose (400 mg/kg) of ethanolic extract of L. elephantum proved against hepatoprotective effects and also the anti-oxidant properties. Its functions are mainly concerned with the removal of free radical species such as hydrogen peroxide, superoxide 386 Bangladesh J Pharmacol 2014; 9: 383-388 Table I Effect of L. elephantum extract on various biochemical parameters in paracetamol-induced hepatotoxicity Group Dose (mg/kg) SGOT (IU/L) SGPT (IU/L) keywords: activity; bangladesh; elephantum; extract; group; liver; paracetamol; pharmacol; rats; serum cache: bjp-19704.pdf plain text: bjp-19704.txt item: #197 of 942 id: bjp-19705 author: Kamalakannan, K.; Balakrishnan, Veluchamy title: Hypoglycemic activity of aqueous leaf extract of Limonia elephantum in alloxan-induced diabetic rats date: 2014 words: 2342 flesch: 57 summary: 9: 443-446 445 Table I Effect of L. elephantum aqueous extract on blood glucose of alloxan-induced diabetic rats Blood glucose mg/dL (Mean ± SEM) Treatment group 0 hour 1 hour 3 hours 5 hours Vehicle 312.9 ± 26.0 320.3 ± 6.2 322.1 ± 2.7 323.8 ± 4.6 L. elephantum 1,000 mg/kg 450.8 ± 26.7 412.7 ± 35.5 362.4 ± 27.6b 372.6 ± 32.7 Metformin 1.5 mg/kg 332.9 ± 2.7 315.7 ± 3.8 302.8 ± 2.6b 274.8 ± 6.7a Values are given as mean ± SEM; ap≤0.01, bp≤0.05 M ea n ch an ge in b lo od gl uc os e (m g/ dL ) 140 120 100 80 60 40 20 0 0 30 60 90 120 Time (min) Vehicle L. elephantum aq extract Metformin A 600 500 400 300 200 100 0 0 30 60 90 120 Time (min) B P er ce nt ag e ch an ge in bl oo d gl uc os e 30 60 90 120 Time (min) C 90 80 70 60 50 40 30 20 10 0 30 60 90 120 Time (min) D120 100 80 60 40 20 0 -20 -40 Figure 1: Oral glucose tolerance test in euglycemic (A) and diabetic (B) rats treated with L. elephantum aqueous extract. Results There was no significant change blood glucose levels of animals treated with L. elephantum extract as well as with metformin as compared to those of vehicle treated controls using oral glucose tolerance test (Figure 1). keywords: elephantum; extract; glucose; hypoglycemic; rats cache: bjp-19705.pdf plain text: bjp-19705.txt item: #198 of 942 id: bjp-19707 author: Ramabharathi, Vatsavaya; Saigopal, Divi Venkata Ramana; Rajitha, Galla title: Antiviral activity of leaf-bud gum-resin of Tarenna asiatica date: 2014 words: 4128 flesch: 56 summary: The number of lesions per leaf in the case of french bean, cowpea and chenopodium of the papaya ring spot virus (PRSV), sesbania mosaic virus (SeMV) and 402 Bangladesh J Pharmacol 2014; 9: 398-405 Table I Viral plaque assay of sample TN-1 (corymbosin) with pre-, post- and simultaneous inoculation treatments with BHK-21 and Vero cell lines Name of Virus (100 TCID50 units of virus) Cell line Control (pfu/well) Dilution Pre-inoculation (pfu/well) Post-inoculation (pfu/well) Simultaneous inocu- lation (pfu/well) BTV BHK-21 92 ± 0.1 1/10 72 ± 0.0 (-21.7)a 54 ± 0.0 (-41.3)a 84 ± 0.0 (-8.7)a 1/100 29 ± 0.0 (-68.5)a 12 ±0.0 (-86.9)a 41 ± 0.0 (-55.4)a 1/1000 12 ± 0.0 (-87.0)a 02 ± 0.0 (-97.8)a 29 ± 0.0 (-68.5)a 1/10,000 02 ± 0.0 (-97.8)a 00 ± 0.0 (100.0)a 09 ± 0.0 (-90.0)a C HIKV Vero 1/10 91 ± 0.0 (-23.5)a 42 ± 0.0 (-64.7)a 102 ± 0.0 (-14.3)a 119 ± 0.0 1/100 41 ± 0.0 (-65.5)a 22 ± 0.0 (-81.5)a 52 ± 0.0 (-56.3)a 1/1000 29 ± 0.0 (-75.6)a 09 ± 0.0 (-92.4)a 22 ± 0.0 (-81.5)a 1/10,000 09 ± 0.0 (-92.4)a 02 ± 0.0 (-98.3)a 12 ± 0.0 (- 89.9)a Results are averages of three replicates of individual experiments. keywords: activity; asiatica; cell; corymbosin; inoculation; leaf; plant; virus; viruses cache: bjp-19707.pdf plain text: bjp-19707.txt item: #199 of 942 id: bjp-19716 author: Bhavaniprasad, Vipperla; Anbarasu, Krishnan; Jayanthi, Sivaraman title: Evolutionary analysis of galectins and identification of potential galectin-1 inhibitors: A computational approach date: 2014 words: 3854 flesch: 52 summary: Papaleo E, Mereghetti P, Fantucci P, Grandori R, De Gioia L. Free-energy landscape, principal component analysis, and structural clustering to identify representative conforma- tions from molecular dynamics simulations: The myoglobin case. O—N 8 Terconazole -4.88 2.8 3.2 (Arg 48) NH—O (His 44) NH—O 9 Isavucanazole -4.32 2.9 (His 44) NH—O 10 Albaconazole -3.98 2.7 (Arg 48) NH—O Figure 4: Molecular dynamics simulations results of Galectin-1 /hexaconazole complex from GROMACS. keywords: analysis; bangladesh; binding; docking; dynamics; energy; figure; galectin-1; galectins; protein cache: bjp-19716.pdf plain text: bjp-19716.txt item: #200 of 942 id: bjp-19730 author: Lin, Er-Jiang; Zhang, Xian; Wang, Da-Ya; Hong, Shi-Zhe; Li, Lei-Yu title: Naringenin modulates the metastasis of human prostate cancer cells by down regulating the matrix metalloproteinases -2/-9 via ROS/ERK1/2 pathways date: 2014 words: 5584 flesch: 58 summary: The present study was undertaken to investigate the effect of naringenin on metastasis of prostate cancer cells by evaluating the expression of MMPs-2/-9 and ERK1/2. The highest concentration of naringenin was most effective in inhibiting survival of prostate cancer cells. keywords: activities; cancer; cancer cells; cells; du145; erk1/2; et al; expression; invasion; matrix; metastasis; migration; naringenin; pc-3; prostate; prostate cancer cache: bjp-19730.pdf plain text: bjp-19730.txt item: #201 of 942 id: bjp-19731 author: Lv, Meng; Wang, Xue Tao; Li, Kun; Wang, Yue Lan title: GABAA receptor binding molecules from Traditional Chinese Medicine: An in silico approach date: 2014 words: 2195 flesch: 55 summary: Bangladesh Journal of Pharmacology Research Article GABAA receptor binding molecules GABAA receptor binding molecules GABAA receptor binding molecules from Traditional Chinese Medicine: from Traditional Chinese Medicine: from Traditional Chinese Medicine: An An An in silicoin silicoin silico approachapproachapproach BJP Introduction The molecular mechanism of general anesthesia is a classical unsolved problem of neuro pharmacology (Miller, 1985), but the advents in the past three decades have shed some insight into how anesthetic drug might work (Urban, 2008). GABAA receptor binding molecules from Traditional Chinese Medicine: An in silico approach. keywords: anesthetic; binding; compounds; drug; gabaa; medicine; protein cache: bjp-19731.pdf plain text: bjp-19731.txt item: #202 of 942 id: bjp-19771 author: Arun, Purushothaman K.; Rajesh, Sivarathri S.; Sundaram, Sankaranarayanan M.; Sivaraman, Thirunavukkarasu; Brindha, Pemiah title: Structural characterizations of lead anticancer compounds from the methanolic extract of Jatropha tanjorensis date: 2014 words: 7535 flesch: 50 summary: Based on the extensive in silico experiments it was understood that methanolic extract of J. tanjorensis brings its anti-cancer activity through inhibiting anti-apoptotic proteins and inducing the activity of pro-apoptotic proteins. It implies that the unique structural architectures of the VN and AN are crucial to accounting their specific interactions with anti-apoptotic proteins over pro- apoptotic proteins. keywords: activity; anti; apoptosis; bangladesh; bcl-2; cancer; cells; compounds; extract; figure; flavonoids; mass; methanolic; min; proteins; tanjorensis cache: bjp-19771.pdf plain text: bjp-19771.txt item: #203 of 942 id: bjp-19772 author: Fu, Qiang; Gao, Zhi-Yu; Zhang, Jie; Sun, Han-Yu; Liu, Chao; Ren, Jin-Hong title: Copper thiosemicarbazones: Antiproliferative action against C6 glioma cells date: 2014 words: 4524 flesch: 58 summary: A wide range of phenotypic modifications were occurred in glioblastoma cells after exposure to the thiosemicarba- zones and its copper complexes. It is well known that glioblastoma cells express wild- type p53 protein (Jones et al., 2003). keywords: activity; bangladesh; cells; cm-1; complexes; compounds; copper; glioblastoma; mol; p53; thiosemicarbazones cache: bjp-19772.pdf plain text: bjp-19772.txt item: #204 of 942 id: bjp-19774 author: Dutta, Satyajit; Ray, Supratim; Nagarajan, K. title: Biological activity of some novel synthesized 2-(4-methylbenzenesulphonamido)pentanedioic acid bis amide derivatives: In vitro and in vivo antineoplastic activity date: 2014 words: 6688 flesch: 70 summary: 2-(4-Methylbenzenesulphonamido)-N,N-(diphenyl) pentane-diamide (5b) White color solid; yield: 88.45%; m.p.: 206-208°C; Rf 0.68; IR (KBr) vmax (cm-1): 2926.24-2653.68 (O-H str. of COOH), 1681.8 (C=O str.), 1577.31 (C=C str. of phenyl ring), 1308.3 (S=O str. 2-(4-Methylbenzenesulphonamido) -N,N -bis(3- chlorophenyl)pentanediamide (5c) White colour solid; yield: 53.64%; m.p.: 154-157°C; Rf 0.82; IR (KBr) vmax (cm-1): 2807-2542 (O-H str. of COOH), 1671.47 (C=O str.), 1507.64 (C=C str. of phenyl ring), 1348 (C-N phenyl ring), 1304.15 (S=O str. keywords: 0.0a; acid; c6h4; h str; nmr; phenyl; str cache: bjp-19774.pdf plain text: bjp-19774.txt item: #205 of 942 id: bjp-19783 author: Qadir, Muhammad Imran; Ali, Muhammad; Ibrahim, Zubair title: Anticancer activity of Morus nigra leaves extract date: 2014 words: 1430 flesch: 57 summary: Anti-cancer activity Single cell suspension was made by trypsin-ethylene- diamine tetraacetic acid (EDTA) and layer of cells was separated. It was concluded that M. nigra possess anti-cancer activity. keywords: activity; cancer; cell; extract; nigra cache: bjp-19783.pdf plain text: bjp-19783.txt item: #206 of 942 id: bjp-19891 author: Zhang, Yue; Quan, Ren-Fu; Cheng, Wei-Shan; Ye, Zhao-Ming; Li, Wei-Xu; Yang, Di-Sheng title: Phenotypic characterization of drug resistance and tumor initiating cancer stem cells from human bone tumor osteosarcoma cell line OS-77 date: 2014 words: 3214 flesch: 53 summary: Hence the elimination of cancer stem cells is an essential goal for eradicating tumor cell of origin and for providing long term disease free survival. Therefore, elucidating the molecular mechanism and signaling pathways involved in cancer stem cells mediated tumorgenesis is essential to target the cancer stem cells inorder to eliminate the tumor relapse (Jordan et al., 2006; Hemmati et al., 2003; Li et al., 2007). keywords: cancer; cells; drug; human; osteosarcoma; resistance; stem; tumor cache: bjp-19891.pdf plain text: bjp-19891.txt item: #207 of 942 id: bjp-19910 author: Mundugaru, Ravi; Chakkravarthy, Madhan; Basavaiah, Ravishankar title: Hepatoprotective activity of fruit extract of Garcinia pedunculata date: 2014 words: 2715 flesch: 50 summary: Microscopic examination of liver sections from parace- tamol treated group showed extensive disturbance in the liver cytoarchitecture in comparison to the sections from normal control liver sections (Figure 1A-D). Liver sections from sylimarin and paracetamol injected rats (C-F). keywords: activity; changes; extract; group; liver; paracetamol; pedunculata; sections cache: bjp-19910.pdf plain text: bjp-19910.txt item: #208 of 942 id: bjp-19921 author: Song, Li Na; Li, Ling Xia; Shi, Qing Hong; Fang, Ling; Sun, Li; Zhao, Hai Feng; Liu, Ning; Li, Hong Jun; He, Cheng Yan title: Periostin as a promising target of therapeutical intervention for colorectal cancer date: 2014 words: 5126 flesch: 57 summary: Periostin is frequently up-regulated in human cancers and implicated in cancer cell proliferation, invasion, and epithelial-mesenchymal transition (Norris et al., 2008). We (avoid) were therefore curious to know whether the targeted down-regulation of periostin cells could induce apoptosis in SW480 cells. keywords: apoptosis; cancer; cells; colorectal; control; et al; expression; hours; patients; periostin; serum; sirna-1; sw480; sw480 cells; tissues cache: bjp-19921.pdf plain text: bjp-19921.txt item: #209 of 942 id: bjp-19922 author: Alamgeer, .; Ghuffar, Aqsa; Ahmad, Taseer; Mushtaq, Muhammad Naveed title: Antihyperlipidemic effect of Berberis orthobotrys in hyperlipidemic animal models date: 2014 words: 4253 flesch: 58 summary: Normal control 86.7 ± 1.7 65.2 ± 0.4 25.4 ± 0.5 45.5 ± 1.8 13.0 ± 0.1 2.3 ± 0.1 3.3 ± 0.1 II High fat diet 266.9 ± .3a 246.2 ± 8.1a 14.4 ± 0.6a 212.2 ± 1.9a 49.2 ± 1.6a 17.5 ± 0.8a 18.5 ± 0.8a III Atorvastatin + High fat diet 76.8 ± 0.3a 56 ± 0.7a 37 ± 0.8a 28.4 ± 0.5a 11.2 ± 0.0a 1 ± 0.0a 2.0 ± 0.0a IV Extract (50 mg/ kg) + Groups TC mg/dL TG mg/dL HDL mg/dL LDL mg/dL VLDL mg/dL AI CRI I Normal control 68.0 ± 0.4 58.2 ± 0.4 41.7 ± 0.2 42.5 ± 0.2 11.6 ± 0.0 0.6 ± 0.0 1.5 ± 0.0 II Olive oil 99.7 ± 0.4a 100.0 ± 0.0a 44.2 ± 0.9ns 66.5 ± 1.1a 20.1 ± 0.9a 1.2 ± 0.0ns 2.2 ± 0.1ns III Atorvastatin + Olive oil 52.0 ± 0.4a 59.6 ± 0.4a 60.0 ± 1.5a 43.7 ± 0.7a 11.9 ± 0.1a 0.0 ± 0.0ns 0.82 ± keywords: cholesterol; control; extract; group; orthobotrys; rats cache: bjp-19922.pdf plain text: bjp-19922.txt item: #210 of 942 id: bjp-19961 author: Hussain, Liaqat; Qadir, Muhammad Imran; Rehman, Shafiq-ur- title: Antihyperglycemic and hypolipidemic potential of Caesalpinia decapetala in alloxan-induced diabetic rabbits date: 2014 words: 2659 flesch: 51 summary: Extract showed dose dependant reduction of anti-hyperglycemic effects in diabetic rabbits of group C and D which are very much comparable to standard drug given alone in Bangladesh J Pharmacol 2014; 9: 529-532 531 Table II Effect of Caesalpinia decapetala on blood glucose level Group Glucose (mg/dL) Pre- treatment Day 0 Day 1 Day 7 Day 14 Control 120.7 ± 4.1 115.0 ± 1.4 112.7 ± 3.0 110.7 ± 2.3 120.7 ± 4.1 Alloxan 119.0 ± 5.6 285.3 ± 4.9 277.3 ± 3.7 286.2 ± 0.9 285.1 ± 1.6 Extract (300 mg) 129.3 ± 4.4 261.5 ± 3.7 249.3 ± 2.0 203.7 ± 2.3 180.1 ± 3.9 Extract (500 mg) 125.8 ± 4.6 249.8 ± 4.0 220.8 ± 3.1 188.0 ± 1.2 156.7 ± 2.4 Glibenclamide (5 mg/kg) 124.3 ± 3.2 245.5 ± 2.0 215.2 ± 2.0 184.0 ± 6.0 150.3 ± 2.0 Glibenclamide (5 mg/kg) + Extract (500 mg/kg, oral) Group H Normal control (Receiving extract only 300 mg/kg oral) Urea and creatinine level were significantly decreased after the administration of C. decapetala extract. keywords: alloxan; decapetala; extract; group; rabbits cache: bjp-19961.pdf plain text: bjp-19961.txt item: #211 of 942 id: bjp-19989 author: Rasul, Azhar; Shen, Xiaoyan; Wang, Bingyu; Liu, Bao; Li, Xiaomeng; Tang, Jilin title: Tubeimoside-1 up-regulates p21 expression and induces apoptosis and G2/M phase cell cycle arrest in human bladder cancer T24 cells date: 2014 words: 5112 flesch: 57 summary: TBMS1-induced apoptosis in T24 cells was consistent with previously reported studies in lung, cervical, and leukemia cancer cells (Weng et al., 2003; Xu et al., 2009; Zhang et al., 2011) Many studies revealed that mitochondrion is one of the essential components of the apoptosis execution machi- nery, which contain pro-apoptotic proteins (e.g., cytochrome c) (Elmore, 2007). Furthermore, TBMS1 has antiproliferative effect and induced apoptosis in cancer cells such as lung cancer (Zhang et al., 2011), cervical cancer (Xu et al., 2009), nasopharyngeal carci- noma (Ma et al., 2008; Weng et al., 2003), melanoma A375 cells (Rasul et al., 2012b), and leukemia HL-60 cells (Yu et al., 1996). keywords: apoptosis; bcl-2; bladder; cancer; cells; cycle; et al; hours; regulation; results; t24; t24 cells; tbms1 cache: bjp-19989.pdf plain text: bjp-19989.txt item: #212 of 942 id: bjp-20017 author: Prabhu, Antonyraj Selva; Ananthan, Gnanakkan title: Alpha-amylase inhibitory activities of ascidians in the treatment of diabetes mellitus date: 2014 words: 1960 flesch: 49 summary: Didemnum vexil- lum 48 ± 0.6 62 ± 0.3 74 ± 0.1 - - - 48 ± 0.6 54 ± 0.3 61 ± 1.0 Trididemnum savignii - - - - - - - 30 ± 0.3 53 ± 0.6 Polyclinum au- rantium - 4 ± 0.2 12 ± 0.1 - - - - 52 ± 0.3 65 ± 0.2 Polyclinum sp. - - - - - - 44 ± 0.2 - - Ascidia ahodori 44 ± 0.2 63 ± 0.3 71 ± 0.6 - - - - 29 ± 0.5 45 ± 0.1 Ascidia sp. - - - 44 ± 0.9 52 ± 0.6 58 ± 0.1 inhibition activity was observed in methanol extracts and showed superior activity for 9 species except T. savignii and the maximum activity was noted in P. mammillata (81%) at 300 µg/mL and the least activity is noted in P. aurantium at 200 µg/mL. Very poor amylase inhibition activity is recorded in acetone extracts and only Microcosmus sp. showed inhibition activity (53%) %Inhibition of ethyl acetate ex- tracts ( µg/mL) Names 100 200 300 100 200 300 100 200 300 Phallusia mam- millata 65 ± 0.2 78 ± 0.0 81 ± 0.9 - - - 40 ± 0.7 12 ± 1.0 35 ± 0.0 Phallusia arabica 45 ± 0.6 65 ± 0.7 68 ± 0.7 - - - 45 ± 0.6 60 ± 0.8 65 ± 0.1 Microcosmus squamiger 40 ± 0.7 60 ± 0.4 68 ± 0.5 - - - 65 ± 0.2 55 ± 0.6 68 ± 0.0 Microcosmus sp. 48 ± 0.1 50 ± 0.5 60 ± 1.2 29 ± 0.3 50 ± 0.6 53 ± 0.1 48 ± 0.0 33 ± 0.5 57 ± 0.9 keywords: activity; inhibition; mammillata cache: bjp-20017.pdf plain text: bjp-20017.txt item: #213 of 942 id: bjp-20342 author: Guan, Guo-Fang; Zhang, De-Jun; Xin, Ding; Wen, Lian-Ji; Yu, Duo-Jiao; Lu, Yan-Qing; Zhao, Yan; Wang, Tie-Jun title: Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer date: 2014 words: 4781 flesch: 60 summary: Abstract Activation of Notch signaling pathway in cancer stem cells plays a crucial role in the regulation of self–renewal and maintenance of side population cells. The presence of side population cells from nasopharyngeal carcinoma for activation of Notch signaling pathways was investigated. keywords: bangladesh; cancer; carcinoma; cells; expression; figure; human; notch; population; population cells; stem; tumor cache: bjp-20342.pdf plain text: bjp-20342.txt item: #214 of 942 id: bjp-20387 author: Lu, Hai-Yan; Peng, Tian-Shu; Hu, Xiang-Dang; Li, Shuai-Jun; Luo, Min; He, Yong-Heng; Nie, Tian title: Quercetin potentiates the effect of γδT cells via modulating the expressions of Granzyme B, perforin and IFN-γ and also regulates the Wnt/δ-catenin signalling pathway in human colon cancer cells date: 2015 words: 5566 flesch: 58 summary: The results suggest that proper concentrations of quercetin could promote proliferation of T cells that can augment immune responses against cancer cells. Results The effects of quercetin at different concentrations (15- 120 µM) on T cells and on colon cancer cells (HT55 and HCT116) were assessed. keywords: -catenin; cancer; cells; colon; control; effect; expression; ht55; human; pathway; quercetin; t cells; wnt/; µm quercetin cache: bjp-20387.pdf plain text: bjp-20387.txt item: #215 of 942 id: bjp-20398 author: Chen, Jun; Wang, Ye; Shi, Wei-Xin title: Wnt5a silencing inhibits the osteosarcoma migration by suppressing PI3K/AKT signaling pathway date: 2014 words: 3915 flesch: 56 summary: The effect of Wnt5a on U2OS and SaOS-2 osteosarcoma cancer cells has been carried out after treating the individual cells with recombinant Wnt5a. The effect of Wnt5a on cell migration via AKT pathways was also demonstrated. keywords: akt; cancer; cell; effect; migration; osteosarcoma; pi3k; proliferation; u2os; wnt5a cache: bjp-20398.pdf plain text: bjp-20398.txt item: #216 of 942 id: bjp-20412 author: Ahmed, Bilal; Ashfaq, Usman Ali; Qamar, Muhammad Tahir ul; Ahmad, Matloob title: Anticancer potential of phytochemicals against breast cancer: Molecular docking and simulation approach date: 2014 words: 2236 flesch: 60 summary: Bangladesh Journal of Pharmacology Research Article Anti-cancer potential of phytochem- icals against breast cancer: Molecu- lar docking and simulation approach BJP Introduction In breast cancer, breast cells lose their normal control and start to proliferate at higher rate as compared to normal cells. Breast cancer is the most familiar form of cancer which affects the women’s around the world and the second major form of cancer which is a cause of death next to the lung cancer. keywords: breast; cancer; docking; drug; estrogen; molecules; receptor; tamoxifen cache: bjp-20412.pdf plain text: bjp-20412.txt item: #217 of 942 id: bjp-20418 author: Ren, Bin; Liu, Chong; Wu, Li-Hua; Jin, Peng; Li, Ping; Liu, Yu-Jie; Yu, Qing-Bo title: Role of SMAD signaling in drug-induced apoptosis in colon cancer date: 2014 words: 3845 flesch: 56 summary: Our results indicate that, ectopic expression of SMAD4 cells increased the response of cancer cells and increased the apoptosis in FET and Caco2 cells (Figure 4). In this study we investigated the response of chemothera- peutic drugs in colon cancer cells that are with (SW620 and SW480) and without aberrations (FET-1 and Caco2) in SMAD signaling. keywords: apoptosis; c u; cancer; cells; drug; f u; signaling; smad; treatments; u r cache: bjp-20418.pdf plain text: bjp-20418.txt item: #218 of 942 id: bjp-20420 author: Rotimi, Solomon O.; Rotimi, Oluwakemi Anuoluwapo; Obembe, Olawole O. title: In silico analysis of compounds characterized from ethanolic extract of Cucurbita pepo with NF-κB-inhibitory potential date: 2014 words: 2813 flesch: 58 summary: Other amino acids involved in the formation of H-bond include Leu for octadecanoic 554 Bangladesh J Pharmacol 2014; 9: 551-556 Figure 3: Stereo view of the binding of ligands to NF-kappa B. The docking algorithm showed that nine phytochemicals fit well into the pocket on NF-κB. Our analysis showed that Lys144 is a prominent residue by involving in the binding of 9-octadecenoic acid (Z)-, methyl ester, hexadecanoic acid, methyl ester and octadecanoic acid, methyl ester with the moldock score of -55.5264, -57.4634 and -61.1258 respectively. keywords: acid; binding; bond; ester; methyl; octadecenoic; pepo cache: bjp-20420.pdf plain text: bjp-20420.txt item: #219 of 942 id: bjp-20435 author: Fatima, Nighat; Kalsoom, Abida; Mumtaz, Amara; Muhammad, Syed Aun title: Computational drug designing of fungal pigments as potential aromatase inhibitors date: 2014 words: 2322 flesch: 46 summary: Aromatase protein residues Arg, Met, Phe, Ser, Tyr, Pro, Asn, Glu, Val, Lys, Gln, Ala, Ile was formed H-bond with ligands molecules. -9.9 4.1 3.0 aRMSD/UB: Root mean square deviation/upper bond; RMSD/LB: root mean square deviation/lower bond Conclusion Docking studies of the monascus, ankaflavin, monas- corubrin and monascorubramine with aromatase enzyme showed that these natural compounds are good ligands which dock well with aromatase target. keywords: aromatase; cancer; docking; ligands; monascin; protein; target cache: bjp-20435.pdf plain text: bjp-20435.txt item: #220 of 942 id: bjp-20455 author: Chen, Hai; Qi, Xiao-Dong; Qiu, Ping title: A novel synthesis of aurones: Their in vitro anticancer activity against breast cancer cell lines and effect on cell cycle, apoptosis and mitochondrial membrane potential date: 2014 words: 5842 flesch: 55 summary: H 20 min/ 95 3j H H H H H OMe 16 min/ 94 3k H H H H OMe OMe 22 min/ 92 3l H H F F H H 15 min/ 95 3m H H CN CN H H 25 min/ 90 3n 4,6-OMe H H H H H 23 min/ 95 3o 4,6-OMe H H H H H 30 min/ 90 All the reactions were carried out using compound 1a or b (1 mmol) and an appropriate aldehyde (1 mmol) in the presence of amberlite IR-120 resin Table III Recycle of the amberlite IR-120 catalyst for the preparation of aurone (3d) keywords: cancer; cell; h h; hours; mhz; nmr cache: bjp-20455.pdf plain text: bjp-20455.txt item: #221 of 942 id: bjp-20471 author: Praneetha, Pallerla; Rani, Vanapatla Swaroopa; Reddy, Yellu Narasimha; Kumar, Bobbala Ravi title: Hepatoprotective studies on methanolic extract of whole plant of Lindernia ciliata date: 2014 words: 5701 flesch: 55 summary: Normal 63.6 ± 3.1 77.4 ± 2.6 339.2 ± 8.1 0.2 ± 0.0 0.04 ± 0.01 8.8 ± 0.3 3.7 ± 0.0 163.4 ± 6.2 12.7 ± 2.1 Toxic 126.8 ± 6.7 366.4 ± 18.3 838.2 ± 8.5 2.1 ± 0.1 1.1 ± 0.1 3.1 ± 0.2 1.8 ± 0.2 385.3 ± 7.9 147.2 ± 4.8 Standard 74.7 ± 1.9a 100.7 ± 3.2a 378.5 ± 8.9a 0.3 ± 0.0a 0.1 ± 0.0a 8.2 ± 0.3a 3.3 ± 0.1a 183.7 ± 4.9a 24.1 ± 5.5a Extract 100 mg/kg 94.9 ± 2.2a 153.3 ± 5.5a 444.7 ± 5.1a 0.5 ± 0.0a 0.4 ± 0.0a 6.7 ± 0.2a 2.7 ± 0.0a 224.1 ± 3.2a 54.1 ± 2.5a Normal 31.4 ± 2.1 63.2 ± 2.8 392.1 ± 7.2 0.1 ± 0.0 0.1 ± 0.0 8.1 ± 0.1 4.9 ± 0.5 221.4 ± 1.5 12.6 ± 3.5 Toxic 132.7 ± 6.1 178.3 ± 4.1 843.2 ± 7.3 2.8 ± 0.1 0.8 ± 0.1 3.0 ± 0.1 2.2 ± 0.3 591.6 ± 2.7 145.6 ± 5.2 Standard 49.3 ± 3.6a 78.3 ± 3.2a 434.3 ± 7.5a 0.4 ± 0.0a 0.1 ± 0.0a 7.2 ± 0.3a 4.4 ± 0.3a keywords: 0.0a; activity; ethanol; extract; liver; paracetamol; radical; rats cache: bjp-20471.pdf plain text: bjp-20471.txt item: #222 of 942 id: bjp-20481 author: Balamurugan, V.; Balakrishnan, Veluchamy; Robinson, J. Philip; Ramakrishnan, M. title: Anticancer and apoptosis-inducing effects of Moringa concanensis using hepG2 cell lines date: 2014 words: 3502 flesch: 59 summary: Bangladesh J Pharmacol 2014; 9: 604-609 607 P er ce nt ag e of v ia bi lit y 120 100 80 60 40 20 0 Control 2 4 6 8 10 20 30 40 50 100 µg/mL Figure 2: Cytotoxic effect of M. concanensis leaf crude extracts against HepG2 cell line Figure 3: Cytotoxicity and apoptotic activity of M. concanensis bark and leaf plant crude extracts against HepG2 cell line (A) Controls cells; (B) bark crude extracts treated HepG2 cells; (C) leaf crude extracts treated HepG2 cells showing cytotoxicity and apoptotic activity Figure 4: Apoptotic DNA fragmentation of HepG2 cells (1) Control, (2) leaf treated showing apoptotic DNA fragmentation of HepG2 cell line (3) bark treated showing apoptotic DNA fragmentation of HepG2 cell line A B C Large scale screening of plant crude extracts on cell culture is an important initial step to determine their potential efficacy in clinical application. Briefly, HepG2 cells were seeded in 96 well plates at a density of 6 x 103 cells per well. keywords: apoptosis; bark; cancer; cell; concanensis; crude; extracts; hepg2; leaf cache: bjp-20481.pdf plain text: bjp-20481.txt item: #223 of 942 id: bjp-20498 author: Yang, Jian; Li, Ji-Xia; Song, Zhe; Xia, Xi-Yan title: Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions date: 2015 words: 2527 flesch: 51 summary: The pathophysiology of allergic transfusion reaction is little known (Heddle, 1999). So in this study we are using computer- aided drug designing platform to find new leads against allergic transfusion reaction. keywords: daucosterol; decarboxylase; drug; energy; histidine; protein; structure; transfusion cache: bjp-20498.pdf plain text: bjp-20498.txt item: #224 of 942 id: bjp-20515 author: Ghori, Syed Safiullah; Khan, Mohib; Rahman, Shaikh Abdul title: Amelioration of carbon tetrachloride- and paracetamol-induced hepatotoxicity in rats by Ficus dalhousiae date: 2014 words: 5092 flesch: 58 summary: Liver diseases are among the most serious disorders. Liver disease is still a worldwide health problem. keywords: activity; ccl4; extract; hepatoprotective; hepatotoxicity; liver; paracetamol; reagent; test cache: bjp-20515.pdf plain text: bjp-20515.txt item: #225 of 942 id: bjp-20534 author: Shuai, Yun-Fei; Wang, Meng-Qing; Xiong, Le-Qin; Liu, Lin; Luo, Yin-He; Peng, Tian-Shu title: Effects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats date: 2014 words: 5656 flesch: 54 summary: Anesthesia cocktail containing isoflurane, nitrous oxide (N2O) and midazolam was reported to downregulate Bcl-xL expression and cause neurotoxi- city in developing rat brains (Yon et al., 2005). Rats were exposed to 1.1% isoflurane for 6 hours (approxi- mately 0.5 MAC) in P7 rats as determined by Orliaguet et al. (2001) in 30% oxygen or air in a temperature- controlled chamber as described before (Li et al., 2013b). keywords: apoptosis; bdnf; brain; cell; control; et al; exposure; expression; isoflurane; platform; pups; rat; rats; vitamin; vitamin c cache: bjp-20534.pdf plain text: bjp-20534.txt item: #226 of 942 id: bjp-20566 author: Hussain, Musaddique; Raza, Shahid Masood; Janbaz, Khalid Hussain title: Pharmacological evaluation and validation for the folkloric use of Oligochaeta ramosa in constipation and diarrhea date: 2014 words: 4637 flesch: 56 summary: Appearance of yellowish brown colora- tion on mixing of Dragendorff’s reagent with HCl treated aqueous plant extract solution, conform the presence of alkaloids in extract. The appearance of pink, violet or red coloration on exposure to NH4OH of the mixture of benzene with aqueous solution of plant extract already acidified with 1% HCl was taken as presence of anthraquinones among the plant constituents. keywords: calcium; effect; extract; o l; ramosa cache: bjp-20566.pdf plain text: bjp-20566.txt item: #227 of 942 id: bjp-20571 author: Nimmakayala, Sridhar; Duggirala, Suguna Lakshmi; Puchchakayala, Goverdhan title: Antimicrobial activity of ethanolic extracts of Justicia neesii date: 2014 words: 2978 flesch: 53 summary: So it was consider worthwhile to elucidate the antimicrobial properties of J. neesii plant extracts. The yield of plant extract was found to be 10.58 % (w/w). keywords: activity; extract; gram; neesii; plant; values cache: bjp-20571.pdf plain text: bjp-20571.txt item: #228 of 942 id: bjp-20602 author: Vinay, Singumsetty; Karimulla, Shaik; Saravanan, Devarajan title: GC-MS analysis, preliminary phytochemical screening, physicochemical analysis and anti-diabetic activity of ethanol extract of Jasminum cuspidatum leaves date: 2014 words: 4367 flesch: 53 summary: Normal control (A); Diabetic control (B); Glibenclamide treated (C); Ethanol extract (200 mg/kg) treated (D); Ethanol extract (400 mg/kg) treated (E) A B C D E treatment with ethanol extract at doses of 200 and 400 mg/kg in streptozotocin-induced diabetic rats produ- ced a significant decrease in blood glucose level, TC, TG, LDL, VLDL and significant increase in HDL, total protein, and body weight when compared to gliben- clamide treated rats and diabetic control rats. Accepted: 5 November 2014 Available Online: 21 November 2014 DOI: 10.3329/bjp.v9i4.20602 Cite this article: Vinay S, Karimulla S, Saravanan D. GC-MS analysis, preliminary phyto- chemical screening, physicochemical analysis and anti-diabetic activity of ethanol extract of Jasminum cuspida- tum leaves. keywords: analysis; control; cuspidatum; diabetic; ethanol; ethanol extract; extract; glucose; rats; streptozotocin cache: bjp-20602.pdf plain text: bjp-20602.txt item: #229 of 942 id: bjp-20610 author: Nadumane, Varalakshmi Kilingar; Timsina, Bibechana title: Anti-cancer potential of banana flower extract: An in vitro study date: 2014 words: 4579 flesch: 59 summary: The ethanol extract had significant cytotoxicity to HeLa cells with an IC50 of 20 µg/mL. By thin layer chromatography we could isolate three fractions out of which fraction 2 had exhibited maximum anti-proliferative effects with an IC50 value of <10 µg/mL. By LC-MS analysis, bioactive fraction was found to have an m/z value of 224.2 indicating it as a novel one. Here, HeLa cells and CHO cells were exposed to the bioactive fraction 2 (20 μg/mL each) for 24 hours. keywords: anti; banana; bioactive; cancer; cells; control; extract; figure; flower; fraction; hela; hours cache: bjp-20610.pdf plain text: bjp-20610.txt item: #230 of 942 id: bjp-20616 author: Abdullah, Syahriel; Gobilik, Januarius; Chong, Khim-Phin title: Comparative study of antibacterial activity between Cynodon dactylon crude and solid phase extraction extracts against selected bacterial pathogens date: 2014 words: 1205 flesch: 45 summary: In general, C. dactylon SPE extracts showed stronger antibacterial activity against the bacterial pathogens compared to plant crude extracts. Disc diffusion bioassays of the C. dactylon crude and SPE extracts showed different extent of antibacterial activity against the selected bacterial pathogens (Table I). keywords: 0.0a; crude; extracts; spe cache: bjp-20616.pdf plain text: bjp-20616.txt item: #231 of 942 id: bjp-20620 author: Ullah, Aftab-; Ahmad, Mahmood; Ahmad, Taseer; Naseer, Faiza Naseer title: Hepatoprotective activity of Sonchus asper in paracetamol-induced hepatic damage in rabbits date: 2015 words: 815 flesch: 55 summary: Bangladesh Journal of Pharmacology Volume: 10; Number 1; Year 2015 Cite this article as: Aftab-Ullah, Ahmad M, Ahmad T, Naseer F. Hepatoprotective activity of Sonchus asper in paracetamol-induced hepatic damage in rabbits. Bangladesh J Pharmacol 2015; 10: 115 Hepatoprotective activity of Sonchus asper in paracetamol-induced hepatic damage in rabbits Sir, Hepatoprotective activity of Sonchus asper against car- bon tetrachloride-induced injuries in male rats was reported (Khan et al., 2012). keywords: group; paracetamol cache: bjp-20620.pdf plain text: bjp-20620.txt item: #232 of 942 id: bjp-20639 author: Naz, Attiqa; Saeed, Muhammad; Hussain, Muhammad Medrar; Ishaq, Muhammad Saqib title: In vitro phytochemical and antimicrobial screening of Thymus linearis date: 2015 words: 2967 flesch: 43 summary: For compound identification of T. linearis extracts, FTIR spectroscopy was used. Preliminary phytochemi-cal screening of plant extracts showed the existence of terpenoids, flavonoids, tannins, alkaloids, glycosides and reducing sugars. keywords: activity; extracts; linearis; plant; strains; thymus cache: bjp-20639.pdf plain text: bjp-20639.txt item: #233 of 942 id: bjp-20642 author: Senthilkumar, Dharmaraj; Anbarasu, Krishnan; Jayanthi, Sivaraman title: Hexonic derivatives as human GABA-AT inhibitors: A molecular docking approach date: 2015 words: 3309 flesch: 55 summary: The rational inhibitor design GABA-AT using class of hexonic acid derivatives as ligand dataset shown in Figure 3. AT model was done using Ramachandran plot cons- truction in Procheck server (Laskowski et al., 1993). keywords: acid; binding; docking; gaba; hexonic; human; ligand; model; protein cache: bjp-20642.pdf plain text: bjp-20642.txt item: #234 of 942 id: bjp-20645 author: Shi, Hui; Long, Yan Xiao; Zhang, Yi; Zhong, Ming; Zheng, Kuang title: Retinoic acid triazole promotes neurotrophin-mediated cell growth and proliferation in nerve cells date: 2014 words: 4193 flesch: 56 summary: Bangladesh Journal of Pharmacology Research Article Retinoic acid triazole promotes neu- rotrophin-mediated cell growth and proliferation in nerve cells BJP Introduction Binding of neurotrophins to membrane receptors of neurons initiates a cascade of intracellular processes which enhance survival and trophic effects. Retinoic acid triazole promotes neurotrophin-mediated cell growth and proliferation in nerve cells Hui Shi1, Yan Xiao Long2, Yi Zhang3, Ming Zhong2 and Kuang Zheng2 1Department of Neurosurgery, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China; 2Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; 3Department of Neurosurgery, Zhengzhou Central Hospital, Zhengzhou 450000, China. keywords: acid; acid triazole; brain; cells; expression; factor; fluorophenyl; hours; nb1643; retinoic; retinoic acid; triazole; trkb cache: bjp-20645.pdf plain text: bjp-20645.txt item: #235 of 942 id: bjp-20648 author: Saleem, Mohammad; Naseer, Faiza title: Medicinal plants in the protection and treatment of liver diseases date: 2014 words: 9058 flesch: 58 summary: Flavonoids also have ability to scavenge the superoxide anion and hydroxyl radicals and terminate chain radical reactions (Kumar et al., 2011). ↑ SOD, CAT, GSH-Px, GST, and GSH Srivastava and Shivanan dappa, 2006 41 Dodonaea viscose (Sapindaceae) Leaves Methanol Alloxan Rabbit ↓ ALT, AST, LDLC, HDL TC and STG Ahmad et al., 2011 42 Eclipta alba (Asteraceae) Whole plant Ethanol PCT Mice ↓ ALT level, fatty degeneration and centrizonal liver necrosis Tabassum et al., 2004 43 keywords: activity; alp; alp levels; alt; ast; bangladesh; carbon; ccl4; ccl4 rat; damage; et al; ethanol; extract; gsh; hepatic; hepatoprotective; hepatotoxicity; leaves; levels; liver; mice; paracetamol; pct; pharmacol; plant; rat ↓; rats; sci; sgot; sgpt; tetrachloride cache: bjp-20648.pdf plain text: bjp-20648.txt item: #236 of 942 id: bjp-20748 author: Dutta, Satyajit; Ravali, G. Raghava; Ray, Supratim; Nagarajan, K. title: Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: In vitro and in vivo antineoplastic activity date: 2015 words: 6936 flesch: 70 summary: The IC50 value refers to the drug concentration that produces a 50% reduction in cellular growth when compared to untreated control cells was determined by plotting a graph of Log (concentration of compound) vs % cell inhibition. Percentage inhibition of ascitic cell = (1 - T/C) keywords: 0.0a; acid; c6h4; h str; phenyl; ring; str cache: bjp-20748.pdf plain text: bjp-20748.txt item: #237 of 942 id: bjp-20825 author: Saleem, Mohammad; Irshad, Iram; Baig, Muhammad Kashif; Naseer, Faiza title: Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits date: 2015 words: 3275 flesch: 55 summary: Then filtration was done with Whatman filter paper No. 1 and the filtrates were concentrated in a rotary evaporator at 61ºC for chloroform extract and at 65ºC for methanol extract. Distill water 0.7 ± 0.0 68.2 ± 4.7 66.8 ± 8.4 117.3 ± 5.3 Distill water + Paracetamol (2,000 mg/kg) 3.3 ± 0.2 165.3 ± 22.4 115.6 ± 12.2 223.3 ± 7.7 Silymarin (100 mg) + Paracetamol (2,000 mg/kg) 0.5 ± 0.0 68.8 ± 7.7 75.5 ± 8.4 133.5 ± 9.9 Chloroform extract (200 mg) + Paracetamol (2,000 mg/kg) 1.8 ± 0.3 98.3 ± 6.6 86.3 ± 4.5 145.6 ± 7.7 Chloroform extract (400 mg) + Paracetamol (2,000 mg/kg) 1.3 ± 0.2 95.3 ± 16.0 82.5 ± 11.9 141.5 ± 9.5 Chloroform extract (600 mg) + Paracetamol (2000 mg/kg) 1.0 ± 0.1 93.6 ± 6.6 80.8 ± 6.4 138.5 ± 6.2 Methanol extract (200 mg) + Paracetamol (2000 mg/kg) 1.6 ± 0.2 99.0 ± 5.9 98.2 ± 6.7 145.0 ± 2.1 Methanol extract (400 mg) + Paracetamol (2,000 mg/kg) 1.2 ± 0.3 80.1 ± 8.0 90.0 ± 5.8 141.7 ± 17.6 Methanol extract (600 mg) + Paracetamol (2,000 mg/kg) 1.1 ± 0.1 76.1 ± 4.7 78.2 ± 7.2 139.5 ± 11.8 Table II Phytochemical analysis of Opuntia monacantha Compounds Chloroform extract Methanol extract Alkaloids + + Polysaccharides + + Tannins + + Saponins + + Flavonoids + + Steroids - - Anthraquinones - - Discussion Paracetamol-induced liver toxicity and cell death are due to generation of toxic metabolites after its meta- bolism through CYP-450 (Ibrahim et al., 2011). keywords: chloroform; extract; hepatoprotective; monacantha; paracetamol cache: bjp-20825.pdf plain text: bjp-20825.txt item: #238 of 942 id: bjp-20849 author: Pu, Zhichen; Yuan, Xiaolong; Zhang, Xuefeng; Chen, Qun; Xie, Haitang title: Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia date: 2014 words: 4872 flesch: 58 summary: Disease free survival of breast cancer patients with CYP2D6*10 wild-type homozygous and heterozygous is higher than that of CYP2D6*10/*10 patients after the tamoxifen treatment, with statistical significance. The results showed, the 5 years DFS of breast cancer patients with CYP2D6*10 wild-type homozygous and heterozygous is slightly higher than that of CYP2D6*10/*10 patients after the TAM treatment, with statistical significance (Figure 2A). keywords: 10/*10; breast; breast cancer; cancer; cancer patients; cyp2d6; dfs; heterogeneity; patients; tam; treatment; type; years cache: bjp-20849.pdf plain text: bjp-20849.txt item: #239 of 942 id: bjp-20879 author: Janbaz, Khalid Hussain; Shabbir, Arham; Mehmood, Malik Hassan; Gilani, Anwarul Hassan title: Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders date: 2014 words: 5048 flesch: 53 summary: Mehrdad M, Zebardast M, Abedi G, Koupaei MN, Rasouli H, Talebi M. Validated high-throughput HPLC method for the analysis of flavonolaglycones, myricetin, quercetin, and kaempferol in Rhus coriaria L. using a monolithic column. Özcan M. Effect of Sumach (Rhus coriaria L.) extracts on the oxidative stability of peanut oil. keywords: ca++; castor; coriaria; effect; extract; oil; rce; rhus cache: bjp-20879.pdf plain text: bjp-20879.txt item: #240 of 942 id: bjp-20883 author: Rahman, Md. Azizur; Hussain, Arshad title: Anti-cancer activity and apoptosis inducing effect of methanolic extract of Cordia dichotoma against human cancer cell line date: 2015 words: 4616 flesch: 53 summary: Whereas, the control groups showed no increase of apoptotic cells and no evident of DNA fragments, it was indicated that MECD could specifically induce apoptosis of cancer cells. Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. keywords: activity; anti; apoptosis; cancer; cells; extract; fluorescence; hela; human; mecd cache: bjp-20883.pdf plain text: bjp-20883.txt item: #241 of 942 id: bjp-20921 author: Wang, Zhi-Gang; Wang, Jin-Peng; Wang, Fang; Wang, Yi-Hua; Cao, Pei-Cheng title: Retinoic acid ortho-hydroxy aniline amide promotes neurotrophin mediated cell growth and proliferation in nerve cells date: 2015 words: 3941 flesch: 57 summary: neural development and functionality, these biomolecules could be applied to facilitate controlled differentiation of stem cells to neurons for therapeutic purposes. The values represent the mean ± S.E.M. of three independent experiments Figure 2: RT-PCR analysis of total RNA from stem cell–derived cultures treated with 20 µM RA and 0.5% FBS (RAA). keywords: acid; amide; cells; days; differentiation; fbs; fos; raa; retinoic; treatment cache: bjp-20921.pdf plain text: bjp-20921.txt item: #242 of 942 id: bjp-20923 author: Zhang, Wu-Jing; Zhu, Ying-Bin; Zhang, Guo-Dong title: Nirtetralin inhibits growth of hepatitis E virus in HepaRG cells date: 2015 words: 3251 flesch: 51 summary: Quantitative analysis of total and closed circular HEV RNA by real-time PCR performed on five independent experiments showed that only 1-5% of the HEV RNA internalized at day 1 post-infection entered the core of the cell refinement. HEV cell culture models HEV genomic RNA was genera-ted from a plasmid construct containing the full-length HEV genome (Kernow-C1 p6 clone, GenBank Accession Number JQ679013) or a construct containing subgeno-mic HEV sequence coupled with a Gaussia luciferase reporter gene (p6-luc), using the Ambion mMESSAGE mMACHINE_ in vitro RNA transcription Kit (Life Technologies Corporation) (Shukla et al., 2011; Shukla et al., 2012). keywords: cells; culture; gene; heparg; hepatitis; hev; nirtetralin; rna; virus cache: bjp-20923.pdf plain text: bjp-20923.txt item: #243 of 942 id: bjp-20975 author: Wang, Si-Ping; Yu, Li; Xie, Jie; Liu, Xiao-Ming; Li, Hong title: Vitexicarpin inhibits overexpression of GNAO1 and plays a role in gastric cancer cell proliferation and apoptosis date: 2015 words: 3074 flesch: 59 summary: Dissemination and growth of cancer cells in metastatic sites. Vitexicarpin inhibits overexpression of GNAO1 and plays a role in gastric cancer cell proliferation and apoptosis Si-Ping Wang1, Li Yu1, Jie Xie1, Xiao-Ming Liu2 and Hong Li1 1Domestic Department of Health Management Institute, The Chinese People’s Liberation Army General Hospital, Beijing, China; 2Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. keywords: cancer; cells; control; gastric; gnao1; migration; mkn-45; proliferation; vitexicarpin cache: bjp-20975.pdf plain text: bjp-20975.txt item: #244 of 942 id: bjp-21068 author: Fang, Yang; Zhou, Hong; Xia, Jian-Fu; Lin, Jie-Jun; Li, Ri-Zeng; Yang, Da-Qing; Xu, Mai-Yu; Li, Xiao-Yang title: Ellagic acid regulates Wnt/beta-catenin signaling pathway and CDK8 in HCT 116 and HT 29 colon cancer cells date: 2015 words: 5278 flesch: 59 summary: Ellagic acid at 50 µM caused a slight decrease in the levels of CDK8 (Figure 4), lower concentrations of ellagic acid, however had not much effect on regulating the expression of CDK8. Study was taken to assess whether ellagic acid modulates Wnt/ -catenin pathway and CDK8 activity in colon cancer cells (HT 29 and HCT 116). keywords: -catenin; acid; cancer; cdk8; cells; colon; ellagic; et al; expression; hct; pathway; signaling; wnt/ cache: bjp-21068.pdf plain text: bjp-21068.txt item: #245 of 942 id: bjp-21085 author: Kuruvalli, Prashanthi; Nadumane, Varalakshmi Kilingar title: In vitro cytotoxic and antibacterial potentials of extracts from three marine isolates of Actinomycetes isolated from coastal ecosystems of Tanur, Kerala, India date: 2015 words: 3803 flesch: 51 summary: Further molecular characterization using 16 S rDNA analyses resulted in the identification of the organisms as P. marina JUACT 04; Streptomyces sindenensis JUACT 06; S. spiroverticillatus JUACT 05. The phylogenetic analysis revealed that P. marina JUACT 04 shows highest affinity with P. marina strain Ms498 by 96%, S. sindenensis JUACT 06 with S. sindenensis strain NBRC 3399 by 89% and S. spiroverticillatus JUACT 05 with S. spiroverticillatus strain NBRC 12821 by 98% bootstarp level (Figure 2). keywords: actinomycetes; bacteria; extracts; fraction; isolates; juact; marine; method cache: bjp-21085.pdf plain text: bjp-21085.txt item: #246 of 942 id: bjp-21096 author: Zhang, Qiang; Wang, Yu-Ting; Jing, Shi-Mei; Chang, Jian-Yong; Wang, Jin-Peng title: Alpha-Naphthylisothiocyanate triggering G2/M phase arrest and apoptosis in human brain malignant glioma U87MG cells via mitochondrial pathway date: 2015 words: 3818 flesch: 53 summary: The results are shown in Figure 3A and B. U87MG cells after exposure to AITC showed that a significant decrease of CDK1 activity (Figure 3A) and down-regulated the protein levels, including CDK1, cyclin B and cyclin A as shown in Figure 3B. To assess the ANIT-induced apoptotic cell death, the results of Western blot analysis from 10 μM of ANIT co- incubation with U87MG cells for 0, 6, 12, 24 and 48 hours are shown in Figure 4A. This was demonstrated by flow cytometric analysis and DAPI staining was applied to confirm cell apoptosis in examined U87MG cells. keywords: anit; apoptosis; arrest; cells; hours; mg cells; phase; u87; u87 mg cache: bjp-21096.pdf plain text: bjp-21096.txt item: #247 of 942 id: bjp-2112 author: Bhukya, Baburao; Anreddy, Rama Narsimha Reddy; William, Carey M.; Gottumukkala, Krishna Mohan title: Analgesic and anti-inflammatory activities of leaf extract of Kydia calycina Roxb. date: 2009 words: 2472 flesch: 56 summary: The number of writhing and stretching was recorded and the % was calculated using the following ratio: % of protection= (Control mean—Treated mean)/Control mean x 100 Screening for anti-inflammatory activity by rat paw edema method The normal paw volumes of all the rats were measured initially and were divided into four groups each consists of six animals treated orally with the vehicle as control (2% gum acacia), standard diclofenac sodium (20 mg/kg) and methanol extract (200 and 400 mg/kg) respectively. Diclofenac Bangladesh J Pharmacol 2009; 4: 101-104 103 Table I Effect of methanol extract of K. calycina on the hot plate test in mice Group Reaction time after administration of control/ standard/extract in sec 0 keywords: analgesic; calycina; extract; paw cache: bjp-2112.pdf plain text: bjp-2112.txt item: #248 of 942 id: bjp-21153 author: Xu, Jin-Kai; Yuan, Qing-Gong; Luo, Peng; Sun, Xiao-Li; Ma, Jian-Cang title: Pleurotus eous polysaccharides suppress angiogenesis and induce apoptosis via ROS-dependent JNK activation and mitochondrial mediated mechanisms in MCF-7 human breast cancer cells date: 2015 words: 5217 flesch: 54 summary: Generation of ROS upon PEP treatment 80 Bangladesh J Pharmacol 2015; 10: 78-86 PEP (µg/mL) C el l v ia bi lit y % 100 80 60 40 20 0 0 50 100 150 200 250 a a a Figure 1: Effect of P. eous polysaccharides on the cell viability of MCF-7 cancer cells. The most important regulator of human tumor angiogenesis is VEGF, also known as VEGF-A or Bangladesh J Pharmacol 2015; 10: 78-86 81 PEP (µg/mL) 0 50 100 150 200 250 A po pt ot ic c el ls % 100 80 60 40 20 0 Figure 2: Influence of P. eous polysaccharides on apoptotic changes in the nucleus of MCF-7 cancer cells Upper. keywords: apoptosis; breast; cancer; cells; eous; et al; expression; human; jnk; mcf-7; membrane; pep; polysaccharides; ros cache: bjp-21153.pdf plain text: bjp-21153.txt item: #249 of 942 id: bjp-21165 author: Dhamija, Isha; Kumar, Nitesh; Pai, K.S.R.; Setty, M. Manjunath; Kumar, Sandeep; Jana, Asim K. title: Exploration of antioxidant and antimicrobial potential of methanolic extract of root stock of Premna herbacea date: 2014 words: 1067 flesch: 40 summary: I: Antimicrobial activity of Premna herbacea extracts and fractions on Gram negative and Gram positive organisms Organism Strain MIC value of various extracts and standard (µg/mL) Aqueous extract, alcoholic extract, ethyl acetate fraction and butanol fraction of alcoholic extract were used for this study. keywords: activity; ethyl; extracts; fraction; herbacea cache: bjp-21165.pdf plain text: bjp-21165.txt item: #250 of 942 id: bjp-21166 author: Ahar, Leile Rahimi; Sadr, Moayad Hossaini; Zare, Karim; Tabatabaei, Samad Motameni title: In vitro antimicrobial evaluation of pyrazolone derivatives date: 2015 words: 3333 flesch: 57 summary: Tetracycline (TE 30), was used as standard for antibacterial activity. Jeon JH, Park JH, Lee HS. 2-isopropyl-5-methylphenol isolated from Ruta graveolens and its structural analogs show antibacterial activity against food-borne bacteria. keywords: activity; bacteria; compounds; mbc; mic cache: bjp-21166.pdf plain text: bjp-21166.txt item: #251 of 942 id: bjp-21171 author: Shoaib, Mohammad; Shah, Ismail; Ali, Niaz; Shah, Syed Wadood Ali title: In vitro acetylcholinesterase and butyrylcholinesterase inhibitory potentials of essential oil of Artemisia macrocephala date: 2015 words: 2972 flesch: 54 summary: Results The detailed GC/MS report of oils of A. macrocephala is given in Table I. In vitro In vitro In vitro acetylcholinesterase and acetylcholinesterase and acetylcholinesterase and butyrylcholinesterase inhibitory po-butyrylcholinesterase inhibitory po-butyrylcholinesterase inhibitory po- tentials of essential oil of tentials of essential oil of tentials of essential oil of Artemisia Artemisia Artemisia macrocephalamacrocephalamacrocephala BJP Introduction Being affordable and accessible, medicinal plants have been as primary and essential part of many people’s life all over the world. keywords: ache; bche; disease; essential; inhibition; macrocephala; oil cache: bjp-21171.pdf plain text: bjp-21171.txt item: #252 of 942 id: bjp-21180 author: Tu, Ju-Hong; Lou, Wei-Hua; Huang, Rong; Zhao, Ai-Min title: Vernolepin regulates apoptosis and autophagy via microtubule formation in ovarian carcinoma cells date: 2015 words: 3083 flesch: 59 summary: All these results indicated that 3-MA could specifically inhibit vernolepin-induced auto- phagy in ovarian cancer cells by inhibiting the increase of LC3. Figure 1: (A) Vernolepin inhibited the proliferation of ovarian cancer cells; (B) Cell cycle was arrested at G2/M phase by vernole- pin. keywords: apoptosis; autophagy; cancer; cells; hours; ov3; ovcar-3; treatment; vernolepin cache: bjp-21180.pdf plain text: bjp-21180.txt item: #253 of 942 id: bjp-21185 author: Chen, Zhen; Gu, Ling-Yun; Zhou, Jun; Wang, Qin; Gao, Hui; Yu, Zhong-He title: Overexpression of phosphorylated MARCKS in the nicotine-derived nitrosamine ketone induced lung cancer mice date: 2015 words: 3562 flesch: 59 summary: Immunohistochemistry Lung tissue samples were collected from the control and NNK induced lung cancer mice at different time intervals namely, 5th, 6th and 7th month after NNK injection. Protein samples were prepared from the lung tissues of NNK induced lung cancer mice along with its control (at different time intervals namely, 5th, 6th and 7th month after NNK injection) and resolved in the 8% SDS-PAGE. keywords: cancer; control; lung; lung cancer; marcks; mice; month; nnk cache: bjp-21185.pdf plain text: bjp-21185.txt item: #254 of 942 id: bjp-21202 author: Asgar, Md. Ali; Senawong, Gulsiri; Sripa, Banchob; Senawong, Thanaset title: Scopoletin potentiates the anti-cancer effects of cisplatin against cholangiocarcinoma cell lines date: 2015 words: 5695 flesch: 49 summary: After exposure to 24 hours, the percentages of cells distributed in different phases of cell cycle were determined by flow cytometry using propidium iodide (PI) staining. Scopoletin prevented proliferation of human prostate tumor PC3 cells by arresting cell cycle at G0/G1 and S phases (Liu et al., 2001). keywords: apoptosis; cancer; cells; cholangiocarcinoma; cisplatin; combination; cycle; effects; hours; kku; kku-100; m214; scopoletin cache: bjp-21202.pdf plain text: bjp-21202.txt item: #255 of 942 id: bjp-21203 author: Liu, Hong; Wang, Chaohua; Yang, Hua; Wang, Fengjie title: Effects of fisetin on oxaliplatin-induced neuropathic pain in mice date: 2015 words: 3360 flesch: 52 summary: Two-way ANOVA failed to reveal significant main effect of fisetin treatment (F [9, 126] = 1.78, p>0.05). Two-way ANOVA revealed significant main effects of fisetin treatment (F [2, 14] = 48.48, p<0.0001) and fisetin × day interaction (F [14, 98] = 9.18, p<0.0001). keywords: effect; fisetin; mice; oxaliplatin; pain; test; treatment cache: bjp-21203.pdf plain text: bjp-21203.txt item: #256 of 942 id: bjp-21208 author: Li, Xiao-Bing; Deng, Yun-Gang; Hu, Jia-Ping; Wang, Zhi; Xie, Rong-Zhen; Luo, Hong; Hu, Xiao-Yun title: Resveratrol overcomes TRAIL resistance in human colon cancer cells date: 2015 words: 4491 flesch: 60 summary: Here, we showed for the first time that the combined treatment with resveratrol and TRAIL drastically induced apoptosis in human colon cancer cells when compared to single treatments. trol overcomes TRAIL resistance in human colon cancer cells. keywords: apoptosis; caco; cancer; cancer cells; cells; colon; death; dr5; effect; et al; figure; results; resveratrol; trail; treatment cache: bjp-21208.pdf plain text: bjp-21208.txt item: #257 of 942 id: bjp-21211 author: Afzal, Muhammad Khurram; Uzair, Muhammad; Chaudhry, Bashir Ahmad title: Anti-cancer activity of Ruellia squarrosa against human prostate cancer cell line date: 2015 words: 1370 flesch: 58 summary: We have evaluated anti-cancer activity of R. squarrosa against human prostate cancer cell lines. Many plants have recently reported with anti-cancer activity like Aspergillus niger (Channabasava et al., 2014) and Morus nigra (Qadir et al., 2014). keywords: activity; cancer; cell; prostate; ruellia; squarrosa cache: bjp-21211.pdf plain text: bjp-21211.txt item: #258 of 942 id: bjp-21214 author: Dai, Yun-Lei; Shao, Gui-Lian; Wang, Fang title: Extract of Brassica rapa suppresses ovalbumin-induced asthma by down-regulating NF-kappaB and p38 MAPK activity date: 2015 words: 5307 flesch: 63 summary: NF-κB activation has been reported to occur rapidly in Bangladesh J Pharmacol 2015; 10: 106-114 111 a 1000 800 600 400 200 0 R I ( % o f c on tro l) a 0 5 10 15 20 25 30 35 40 A a a a a a a a a a Methacholine (mg/mL) Control OVA 125 mg BRCE + OVA 250 mg BRCE + BALF collected 24 hours following OVA challenge in OVA-sensitized mice resulted in marked infiltration of inflammatory cells. keywords: airway; asthma; brce; control; extract; ige; mg brce; mice; ova; p38; rapa cache: bjp-21214.pdf plain text: bjp-21214.txt item: #259 of 942 id: bjp-21324 author: Li, Wenbin; Sun, Hongyan; Zhou, Jianwu; Zhang, Yabiao; Liu, Linjie; Gao, Ye title: Antibacterial activities, anti-oxidant contents and antioxidant properties of three traditional Chinese medicinal extracts date: 2015 words: 5682 flesch: 53 summary: Fu R, Zhang YT, Guo YR, Liu FX, Chen F. Determination of phenolic contents and anti-oxidant activities of extracts of Jatropha curcas L. seed shell, a by-product, a new source of natural anti-oxidant. Composition and anti-oxidant activity of aqueous and ethanolic Pelargonium radula extracts. keywords: activity; anti; antibacterial; baicalensis; chinese; extracts; oleraceus; plants; value cache: bjp-21324.pdf plain text: bjp-21324.txt item: #260 of 942 id: bjp-21329 author: Neeraja, Kosanam; Debnath, Rabindra; Firdous, S. M. title: Cardioprotective activity of fruits of Sechium edule date: 2015 words: 3403 flesch: 47 summary: A lectin from the exudate of S. edule was purified (Vozari-Hampe et al., 1992). Twenty known Gibberellins’ have been identified in extracts of the seeds of S. edule (Albone et al., 1984). keywords: cholesterol; edule; extract; group; isoproterenol; rats; sechium cache: bjp-21329.pdf plain text: bjp-21329.txt item: #261 of 942 id: bjp-21462 author: Alam, Fiaz; Saqib, Qazi Najumus; Waheed, Abdul title: Effect of crude saponins from Gaultheria trichophylla extract on growth inhibition in human colorectal cancer cells date: 2015 words: 3897 flesch: 57 summary: The effect of plant extracts on cancer cells was quantified as the percentage of control absorbance of reduced dye at 550 nm on microplate reader (LabtechLT-4000MS, Labtechm International Ltd., East Sussex, and UK). The blue- fluorescent DAPI nucleic acid stain preferentially stains DNA and is used to study the morphological condition of cancer cells, espe-cially as a marker for apoptosis in the cells. keywords: assay; caco-2; cancer; cells; crude; extract; growth; mtt; saponins; trichophylla cache: bjp-21462.pdf plain text: bjp-21462.txt item: #262 of 942 id: bjp-21463 author: Alam, Nazmun Nahar; Ara, Ferdous; Iqbal, Md. Jalal Uddin title: Prescribing pattern of psychotropic drugs used in non-psychiatric patients among outpatient department of two teaching hospitals in Bangladesh date: 2015 words: 2444 flesch: 54 summary: Psychotropic drug use were 60.3% in female and 39.7% in male in SSMC and 66.7% were female and 33.3% were male in HFRCMCH. This study also found that psychotropic drug use were more in female than male. keywords: bangladesh; drugs; health; patients; prescribing; use cache: bjp-21463.pdf plain text: bjp-21463.txt item: #263 of 942 id: bjp-21467 author: Kahiya, Charmaine; Zimudzi, Clemence title: Phytochemical, antimicrobial and cytotoxic evaluation of Indigofera serpentinicola date: 2015 words: 3965 flesch: 56 summary: Figure 1: Brine shrimp mortality against methanol extract concentration 170 Bangladesh J Pharmacol 2015; 10: 166-172 Probits Linear (Probits) Y = -3.612x + 7.8096 R2 = 0.9245 Probit analysis of aqueous extract cytotoxicity P ro bi t 8 6 4 2 0 0 0.5 1 1.5 Log concentration Figure 2: The LC50 values for both extracts were less than <1000 µg/mL that Meyer et al. (1982) noted to be the threshold of toxicity for plant extracts. keywords: activity; extract; growth growth; plant; presence; test; water cache: bjp-21467.pdf plain text: bjp-21467.txt item: #264 of 942 id: bjp-21475 author: Paul, Saikat Ranjan; Hakim, Md. Lukman title: In vivo hypoglycemic study of Manilkara zapota leave and seed extracts date: 2015 words: 3705 flesch: 65 summary: min 15 min 30 min 60 min 90 min 120 min Glucose control 4.7 ± 0.1 15.4 ± 0.2 12.3 ± 0.1 12.3 ± 0.1 10.3 ± 0.1 6.7 ± 0.3 Positive control 4.8 ± 0.1 12.2 ± 0.1 9.3 ± 0.1 7.2 ± 0.1 5.1 ± 0.1 4.2 ± 0.1 PMZL (150 mg/kg) 4.9 ± 0.1 15.2 ± 0.2 11.7 ± 0.1 9.8 ± 0.1 8.0 ± 0.1 6.6 ± 0.1 MMZS (150 mg/kg) 4.6 ± 0.1 15.2 ± 0.1 11.3 ± 0.1 9.1 ± 0.1a 7.3 ± 0.1a 6.3 ± 0.1 PMZL (300 mg/kg) 4.6 ± 0.1 14.8 ± 0.1 10.6 ± 0.1a 8.3 ± 0.1a 6.7 ± 0.1a 5.7 ± 0.1 MMZS (300 mg/kg) 4.7 ± 0.1 14.4 ± 0.1 10.1 ± 0.1a 8.1 ± 0.1a 6.4 ± 0.1a 5.3 ± 0.1 Values are expressed as mean ± SEM (n = 5); ap< 0.0001, when compared with positive control Table II Effects of extracts of Manilkara zapota on blood glucose level in alloxan (70 mg/kg) induced diabetic mice Blood glucose level (mmol/L) Group 1st day 2nd day 3rd day 4th day 5th day 6th day 7th day Normal control 5.4 ± 0.1 5.6 ± 0.1 5.5 ± 0.1 5.8 ± 0.1 5.6 ± 0.1 5.8 ± 0.1 5.6 ± 0.1 Diabetic control 12.7 ± 0.1 14.3 ± 0.1 16.4 ± 0.1 17.1 ± 0.1 18.5 ± 0.1 18.7 ± 0.1 18.9 ± 0.3 PMZL (150 mg/kg) 11.6 ± 0.1 10.3 ± 0.1a 9.1 ± 0.1a 8.5 ± 0.1a 7.8 ± 0.1a 7.5 ± 0.1a 7.3 ± 0.1a MMZS (150 mg/kg) 12.1 ± 0.1 11.1 ± 0.1a 10.2 ± 0.1a 9.3 ± 0.1a 8.6 ± 0.1a 7.5 ± 0.1a 6.8 ± 0.1a PMZL (300 mg/kg) 12.7 ± 0.1 11.3 ± 0.1a 10.4 ± 0.1a 8.8 ± 0.1a 7.5 ± 0.1a 6.7 ± 0.1a 6.5 ± 0.1a MMZS (300 mg/kg) 12.6 ± 0.1 10.4 ± 0.1a 8.7 ± 0.1a 7.7 ± 0.1a 6.9 ± 0.1a 6.2 ± 0.1a 6.0 ± 0.1a Metformin (100 mg/kg) 11.7 ± 0.1 8.3 ± 0.1a 6.4 ± 0.1a 5.5 ± 0.1a 4.5 ± 0.1a 4.2 ± 0.1a 3.8 ± 0.1a Values are expressed as mean ± SEM (n = 5); ap< 0.0001, when compared with diabetic control 61.2% (300 mg/kg of PMZL), 63.2% (300 mg/kg of MMZS) and 65.1% (100 mg/kg of metformin). Manilkara zapota seed embryo extract: A potent anthelminthic agent. keywords: 0.1a; glucose; manilkara; mice; weight; zapota cache: bjp-21475.pdf plain text: bjp-21475.txt item: #265 of 942 id: bjp-21566 author: Lu, Jian-Hong; Shen, Zhen; Zhang, Shu-Xin; Zhang, Jin-Yu title: Design, synthesis and biological evaluation of novel bergapten derivatives as potent lipid lowering agents date: 2015 words: 3818 flesch: 56 summary: Among all the tested analogs, compound 5 displayed the best activity with overall triglyceride lowering activity of 41%. 1H NMR (400 MHz, CDCl3): δ 3.81 (3H, s), 3.89 (3H, s), 6.29 (1H, d, J=16Hz), 6.86 (1H, d, J=2.28 Hz), 7.09 (1H, s), 7.44 (1H, d, J=2.65 Hz), 6.29 (1H, d, J=15.55 Hz); 13C NMR (100 MHz, CDCl3): δ 56.33, 60.65, 93.82, 105.66, 112.53, 116.54, 123.36, 135.23, 146.77, 152.57, 156.57, 157.35, 169.01;IR (KBr) maxcm-1: 2941, 1682, 1608, 1593, 1486, 1384, 1366, 1314, 1266, 1162, ESI-MS (m/z): 249.07 (M+ H) +. keywords: activity; bergapten; cdcl3; mhz; nmr cache: bjp-21566.pdf plain text: bjp-21566.txt item: #266 of 942 id: bjp-21599 author: Ding, Hao; Wang, Ben-Zhong; Zhu, Hua-Qing; Dong, Liu-Yi; Gu, Yu-Fang; Zhao, Yu title: Targeting breast cancer using retinoic acid trifloromethyl chalcone: A promising therapeutic strategy in the treatment of breast cancer date: 2015 words: 2847 flesch: 61 summary: In conclusion, administration of RAFC, suppressed the number of rats with tumor, number of tumors per rat, and volume of malignant breast tumors induced by DMBA in female rats. The data revealed a significant decrease in number of rats with mammary tumor, number of tumors per rat and tumor volume by 54, 72 and 75% respectively in RAFC group compared to control group. keywords: breast; cancer; group; ibuprofen; number; rafc; rats; tumor cache: bjp-21599.pdf plain text: bjp-21599.txt item: #267 of 942 id: bjp-21641 author: Zhu, Rui-Xia; Zhao, Lei; Zhang, Yu-Kun; Luo, Peng; Liu, Si-Hai; Wang, Jin-Guang title: Sequential treatment with ursolic acid chlorophenyl triazole followed by 5-fluorouracil shows synergistic activity in small cell lung cancer cells date: 2015 words: 4758 flesch: 60 summary: In the present study the effect of sequential treatment of UACT (Figure 1) followed by 5-FU on small cell lung cancer cells was investigated. In the present study the effect of sequential treatment of ursolic acid chlorophenyl triazole (UACT) followed by 5-fluorouracil (5-FU) on human small cell lung cancer cells was investigated. keywords: cancer; cells; combination; h209; hours; lung; tnf; treatment; uact cache: bjp-21641.pdf plain text: bjp-21641.txt item: #268 of 942 id: bjp-21642 author: Liu, Tian-Dan; Yang, Ke; Li, Fu-Kui title: Neuroprotective effects of pterostilbene against isoflurane-induced apoptosis through regulating the JNK and PI3K/Akt pathway in neonatal rats date: 2015 words: 5874 flesch: 52 summary: Isoflurane-induced neuronal apoptosis and degenera- tion has been observed to occur via JNK pathway and also through disruption of intracellular calcium homeo- stasis and hyperactivation of inositol 1,4,5-trisphos- phate (IP3) receptors (Li et al.,2013b; Wei et al., 2008; Pterostilbene was able to offer effective neuroprotection against isoflurane induced apoptosis and neurodegene- ration by modulating JNK and PI3/Akt pathways and as well improved the memory and cognitive perfor- mance of rats. keywords: akt; apoptosis; control; et al; exposure; isoflurane; jnk; memory; pathway; platform; pterostilbene; rats; trials cache: bjp-21642.pdf plain text: bjp-21642.txt item: #269 of 942 id: bjp-21658 author: Biradi, Mahesh; Hullatti, Kirankumar title: Cytotoxic activity of isolated constituents from leaves of Premna serratifolia on MCF-7 and HT-29 cell lines date: 2015 words: 2491 flesch: 55 summary: Two isolates were found to be active and which were tested on cancer cell lines MCF-7 and HT-29 for their cytotoxicity. As part of ongoing investigation P. serratifolia plant has been selected for bioactivity guided isolation and here cytotoxic activity of two isolated constituents from the n-hexane soluble fraction (unsaponifiable portion) of methanolic extract of P. serratofolia leaves on human cancer cell lines. keywords: activity; cancer; cell; fractions; lines; premna; serratifolia cache: bjp-21658.pdf plain text: bjp-21658.txt item: #270 of 942 id: bjp-21689 author: Gul, Humaira; Abbas, Khizar; Qadir, Muhammad Imran title: Gastro-protective effect of ethanolic extract of Mentha longifolia in alcohol- and aspirin-induced gastric ulcer models date: 2015 words: 3354 flesch: 53 summary: Gastric mucosa of alcohol (1 mL of 80%)-induced ulcer have shown intramucosal hemorrhages and aspirin (200 mg/kg) induced ulcer has shown striking necrosis of mucosal cells with associated hemorrhages (Figure 1). Normal saline 2 mL/kg 3.7 ± 0.1 - Group 2 (Standard) Ranitidine 20 mg/kg 0.8 ± 0.0b 78.2 ± 1.4b Group 3 (Alcohol- induced ulcer) keywords: extract; longifolia; qadir; ulcer cache: bjp-21689.pdf plain text: bjp-21689.txt item: #271 of 942 id: bjp-21699 author: Zhu, Guo-Min; Huang, Guo-Dong title: Chemical synthesis, docking studies and biological effects of functionalized 1,3-diaryl-2-propen-1-ones on human colon cancer cells date: 2015 words: 8091 flesch: 65 summary: Trans-3-(1H-indol-3-yl)-1-(4’-flouro-3’-methylphenyl)- 2-propen-1-one (1a) Orange powder; 20% yield; mp 59-60°C; IR νmax(KBr): 3422, 1548, 1154, 737 (NH), 1653 (chalcone C=O), 1520, 1491, 1440(aromatics) Trans-3-(1H-indol-3-yl)-1-(anthracenyl)-2-propen-1- one (1c) Yellow powder; 80% yield; mp 108-109°C; IR νmax(KBr): 3395, 1561, 1164, 746 (NH), 1649 (chalcone C=O), 1515, 232 Bangladesh J Pharmacol 2015; 10: 230-240 Indole-3-carbinol + N H OHC CH3 O R 1 O NH R 5 4 b CH3 O CH3 O R 1 R 1 3h. keywords: anti; c-1; c-2; c-3; c-6; cancer; chalcone; compounds; h-2; h-6; mhz; nmr cache: bjp-21699.pdf plain text: bjp-21699.txt item: #272 of 942 id: bjp-21711 author: Reza, Hasan Mahmud; Sagor, Md. Abu Taher; Alam, Md. Ashraful title: Iron deposition causes oxidative stress, inflammation and fibrosis in carbon tetrachloride-induced liver dysfunction in rats date: 2015 words: 4824 flesch: 54 summary: Bangladesh Journal of Pharmacology Research Article Iron deposition causes oxidative Iron deposition causes oxidative Iron deposition causes oxidative stress, inflammation and fibrosis in stress, inflammation and fibrosis in stress, inflammation and fibrosis in carbon tetrachloridecarbon tetrachloridecarbon tetrachloride---induced liver induced liver induced liver dysfunction in ratsdysfunction in ratsdysfunction in rats BJP Introduction Hepatic cirrhosis or liver fibrosis is known to be an irreversible process in liver due to chronic insult such as, diabetes, high fat diet or viral infection in the liver. Carbon tetrachloride (CCl4) is a known hepatotoxin, frequently used to induce liver fibrosis in animal models ( keywords: ccl4; cells; control; deposition; fibrosis; hepatic; iron; liver; plasma; rats; stress; weight cache: bjp-21711.pdf plain text: bjp-21711.txt item: #273 of 942 id: bjp-21716 author: Mbhele, Nobuhle; Balogun, Fatai O.; Kazeem, Mutiu I.; Ashafa, Tom title: In vitro studies on the antimicrobial, antioxidant and antidiabetic potential of Cephalaria gigantea date: 2015 words: 6024 flesch: 53 summary: A sensitive and quick microplate method to deter- mine the minimal inhibitory concentration of plant extracts for bacteria. The observed reduced inhibition of micro-organisms by the water and hydro-ethanol extracts of C. gigantea leaf may not be unconnected with -3 -2 -1 0 1 2 3 0.5 1.0 1.5 Extract Control 1 /v ( m M /m in ) Bangladesh J Pharmacol 2015; 10: 214-221 219 -3 –2 –1 0 1 2 3 1/[S] (mM)-1 1/ v (m M /m in 1.5 1.0 0.5 Control Extract Figure 1: Mode of inhibition of α-amylase by water extract of Cephalaria gigantea root 10 20 30 Extract Control 1 /v ( m M /m in ) 1/[S] (mM)-1 1/ v (m M /m in Control Extract -3 –2 –1 0 1 2 3 30 20 10 Figure 2: Mode of inhibition of α-glucosidase by ethanol extract of Cephalaria gigantea leaf the fact the active antimicrobial agents in the plant may be non-polar (Mabona and Van Vuuren, 2013). keywords: activity; amylase; anti; ethanol; extracts; gigantea; inhibition; leaf; root; water cache: bjp-21716.pdf plain text: bjp-21716.txt item: #274 of 942 id: bjp-21739 author: Hang, Meng; Zhao, Fan; Chen, Shu-Bo; Sun, Qing; Zhang, Chun-Xiao title: Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition date: 2015 words: 2529 flesch: 51 summary: The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol exhibited maximum anti-proliferative potential at a concentration of 140 μM and lowest at 10 μM. Only such concentrations (10, 20, 40 and 60 µM) which exhibited lesser influence on the viability of A549 cells were used in all subsequent experiments In hi bi to ry e ffe ct Figure 1: Inhibitory effects of kaempferol on the proliferation of non-small cell lung cancer cells. keywords: a549; cancer; cells; emt; hours; kaempferol; lung cache: bjp-21739.pdf plain text: bjp-21739.txt item: #275 of 942 id: bjp-21753 author: Jia, Yan; Jia, Zan-Hui; Chen, Jun; Zhu, He; Cui, Man-Hua title: Ursolic acid benzaldehyde chalcone leads to inhibition of cell proliferation and arrests cycle in G1/G0 phase in ovarian cancer date: 2015 words: 4518 flesch: 60 summary: In the present study, the effect of ursolic acid benzaldehyde chalcone (UABC) on ovarian carcinoma cells was studied. Not only ursolic acid but its derivatives also induce apoptosis in a variety of cancer cells (Es-Saady et al., 1992;1996) A Journal of the Bangladesh Pharmacological Society (BDPS) keywords: acid; apoptosis; cancer; carcinoma; cells; control; gli1; hedgehog; hours; inhibition; ovarian; treatment; uabc cache: bjp-21753.pdf plain text: bjp-21753.txt item: #276 of 942 id: bjp-21754 author: Perveen, Rawshan Ara; Rahman, Md. Sayedur title: Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study date: 2015 words: 5941 flesch: 54 summary: 120 Bangladesh J Pharmacol 2015; 10: 116-124 0 1 2 3 4 5 6 7 8 9 10 Doses Baseline 1 2 3 4 P in te ns ity (V A S ) 10 8 6 4 2 0 x y A B Figure 3: Differences in pain intensity after administration of solution prepared by sustained release tablets with and with- out added preservatives in a day x: solutions prepared without added preservative; y: solutions prepared with added preservative Figure 4: Cumulative pain relief score after administration of morphine solution prepared from sustained release tablets and injectable formulations with and without added preservative x: Total pain relief score of 7 (80x7) patients included in solutions with- out added preservative and 9 (80x9) patients included in solutions with added preservative; y: Cumulative pain relief score after morphine solution administration prepared from sustained release tablets; z: Cumulative pain relief score after morphine solution administration prepared from injectable formulation Solutions without added preservative Groups C um ul at iv e pa in re lie f s co re 800 600 400 200 0 Solutions with added preservative X Y Z Morphine usually produces these metabolites when it comes in contact with atmospheric oxygen. In the present study, morphine solution from sustained release tablet was prepared, which was comparatively A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2015; 10: 116-24 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: keywords: administration; bangladesh; formulation; morphine; pain; patients; preservative; release; solution; study cache: bjp-21754.pdf plain text: bjp-21754.txt item: #277 of 942 id: bjp-21811 author: Janbaz, Khalid Hussain; Saqib, Fatima title: Pharmacological evaluation of Dactyloctenium aegyptium: An indigenous plant used to manage gastrointestinal ailments date: 2015 words: 4931 flesch: 52 summary: i.e., Lactuca serriola (Janbaz et al., 2013b), Cletis africana (Khan et al., 2012), Carthamus oxycantha (Gilani et al., 2005a), Calendula officinalis (Bashir et al., 2006) apparently to keep spasmogenic and spasmolytic effects within tolerable limits by the nature. The contractile activity of test materials on isolated rabbit jejunum preparations is comparable to that of acetylcholine (ACh), which can be suppressed on pretreatment with atropine (0.1 µM) (Janbaz et al., 2013). keywords: activity; aegyptium; ca++; contractions; da.cr; effect; extract; jejunum; preparations; rabbit; tissue cache: bjp-21811.pdf plain text: bjp-21811.txt item: #278 of 942 id: bjp-21869 author: Janbaz, Khalid Hussain; Hassan, Waseem; Mehmood, Malik Hassan; Gilani, Anwar Hassan title: Antidiarrheal and antispasmodic activities of Adiantum capillus-veneris are predominantly mediated through ATP-dependent K+ channels activation date: 2015 words: 4378 flesch: 51 summary: Khan et al., 2011) or Ca++ channel blockade (Mehmood et al., 2011; Janbaz et al., 2014), respectively. A. capillus- veneris is traditionally used to treat abdominal colic, diarrhea asthma, cough, diabetes and constipation (Duke et al., 2002). keywords: capillus; effect; et al; extract; pharmacol; veneris cache: bjp-21869.pdf plain text: bjp-21869.txt item: #279 of 942 id: bjp-21876 author: Li, Wei-Guo; Wang, He-Qun title: Design and synthesis of a novel 5-(aminomethylene)thiazolidine-2,4-dione derivatives as potent hepatitis-B virus polymerase inhibitors date: 2015 words: 4443 flesch: 63 summary: By structural biology, we estab- lished a screening system for anti-HBV compounds that target on nucleocapsid. All the target compounds were tested in vitro in HepG2.2.15 cells for anti-HBV activity and cytotoxicity. keywords: compounds; dione; hbv; mhz; nmr cache: bjp-21876.pdf plain text: bjp-21876.txt item: #280 of 942 id: bjp-21909 author: Alluri, Narendranath; Majumdar, Mala title: In vitro anticancer potential and GC-MS analysis of Drimia nagarjunae, an endangered medicinal plant date: 2015 words: 2639 flesch: 61 summary: Among Drimia species, D. indica and D. maritima have reported to exhibit anti-cancer activity (Ganesh et al., 2012; Bozcuket al., 2011). No pharmacological investigation in the perspec-tive of anti-cancer activity has yet been reported on D. nagarjunae. keywords: activity; cancer; chl; eae; extracts; nagarjunae cache: bjp-21909.pdf plain text: bjp-21909.txt item: #281 of 942 id: bjp-21931 author: Revathi, Ponnusamy; Parimelazhagan, Thangaraj title: Anti-diabetic analysis and insulin expression study of a wild leafy vegetable Acalypha alnifolia Klein ex wild. on streptozotocin-induced diabetic rats date: 2015 words: 3962 flesch: 50 summary: The effect is might be due to the anti-oxidant and secondary metabolites (Revathi et al., 2013a) were better in A. alnifolia acetone extract. To overcome the hypoglycemia which occurred during the first 24 hours following the STZ administration, diabetic rats were orally given 5% glucose solution. keywords: acetone; alnifolia; animals; extract; glucose; insulin; rats; study cache: bjp-21931.pdf plain text: bjp-21931.txt item: #282 of 942 id: bjp-21945 author: Wang, Zhan-Ying; Liu, Wen-Qiong; Wang, Si'e; Wei, Zeng-Tao title: Fisetin induces G2/M phase cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation in human endometrial cancer cells date: 2015 words: 4448 flesch: 54 summary: G0/G1 S G2/M Figure 2: Effect of fisetin on cell cycle in KLE cells Fisetin at (20-100 µM) induces G2/M cell cycle arrest in KLE cells in a dose and time–dependent manner. DNA damage sensor, ataxia telangiectasia mutated (ATM) controls cell cycle arrest at G1 and G2 and blocks DNA synthesis that is in progress. keywords: arrest; atm; cancer; cdc25c; cell; cycle; cyclin; fisetin; hec1; kle cache: bjp-21945.pdf plain text: bjp-21945.txt item: #283 of 942 id: bjp-22246 author: Mushtaq, Sohaib; Chaudhry, Mueen Ahmad; Rahman, Hafiz Muhammad Abdul title: Calcium channels blocked activity: Providing the basis for medicinal use of Abies pindrow in diarrhea and bronchitis date: 2015 words: 3610 flesch: 54 summary: In our previous studies, involvement of calcium channel blocking activity was observed as underlying cause of spasmolytic effect of crude extract (urRahaman et al., 2013; Chaudhary et al., 2012). The presence of calcium channel blocking activity in crude extract may give the possible explanation for traditional use of plant in diarrhea. keywords: activity; calcium; concentration; extract; pindrow; tissue; verapamil cache: bjp-22246.pdf plain text: bjp-22246.txt item: #284 of 942 id: bjp-22275 author: Shui, Yanping; Tang, Youmei; Zhang, Xuefeng; Ge, Jun; Pu, Zhichen title: Adjuvant chemotherapy of megestrol acetate in advanced breast cancer: A meta-analysis date: 2015 words: 4436 flesch: 58 summary: Lu WB, Ding H. Adjuvant treatment of megestrol acetate (MPA) on breast cancer chemotherapy patients: A clinical observation. Pu Z, Yuan X, Zhang X, Chen Q, Xie H. Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia. keywords: acetate; adjuvant; analysis; breast; breast cancer; cancer; chemotherapy; megestrol; patients; studies; trials cache: bjp-22275.pdf plain text: bjp-22275.txt item: #285 of 942 id: bjp-22285 author: Hussain, Musaddique; Raza, Shahid Masood; Janbaz, Khalid Hussain title: Pharmacological basis for the folkloric uses of Buxus wallichiana in gastrointestinal, respiratory and vascular disorders date: 2015 words: 4116 flesch: 47 summary: Crude extract shifted the Ca+2-concentration response curves at the dose range of 0.3–1.0 mg/mL (n=3) to the right, like that caused by verapamil at 0.1–0.3 μM (n=3), thus conforming that observed relaxant effect was likely to be mediated through calcium channel blocking effect (Figure 7 A & B). In atropinized jejunum preparation, crude extract inhibited the spontaneous and K+ (80 mM)-induced contraction, suggesting that spasmolytic effect is mediated through the Ca+2-channel blockade. keywords: ca+2; effect; extract; preparations; rabbit; verapamil; wallichiana cache: bjp-22285.pdf plain text: bjp-22285.txt item: #286 of 942 id: bjp-22287 author: Emeka, Emordi Jonathan; Oluwatoyin, Agbaje Esther; Adekunle, Oreagba Ibrahim; Ignis, Iribhogbe Osede title: Preliminary phytochemical screening and evaluation of hypoglycemic properties of the root extract of Uveria chamae date: 2015 words: 4208 flesch: 60 summary: Decrease in blood glucose level occurred after 30 min but the blood glucose level failed to return to baseline after 120 min. There was a significant decrease (p<0.05) in blood glucose levels at 30, 60 and 120 min with a percentage decrease of 57.5, 28.6 and 41.4% respectively in the group of rats treated with 500 mg/kg dose of extract compared with control. The oral glucose tolerance test result also showed a significant decrease (p<0.05) in blood glucose levels. keywords: blood; chamae; diabetes; extract; glucose; group; hours; levels; rats cache: bjp-22287.pdf plain text: bjp-22287.txt item: #287 of 942 id: bjp-22334 author: Sharma, Bhawna; Dhamija, Isha; Kumar, Sandeep; Chaudhary, Hema title: In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma date: 2015 words: 5717 flesch: 56 summary: These results could indicate either a direct tumorigenic effect of extract on tumor cells or an indirect effect (Dhamija et al., 2013; Zandi et al., 2013). Significant %reduction in tumor volume was observed in extract treated group when compared to EAC control group. keywords: cell; control; eac; extract; group; mice; nervosa; test; tumor cache: bjp-22334.pdf plain text: bjp-22334.txt item: #288 of 942 id: bjp-22424 author: Fan, Mao-Chuan; Han, Guang-Ye; Zhang, Xin-Jun; Xi, Hui-Fang title: Studies of in vitro anti-prostate cancer potential of newer 1,2,4-triazolo-1,3,4-thiadiazines with different heteroaromatics date: 2015 words: 5038 flesch: 59 summary: 3-(3-((1H-benzo[d]imidazol-1-yl)methyl)-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-2H-chromen-2- one (1) Yield 71%, m.p. 256-258°C, IR (KBr, cm–1): 3049 (Ar-H), 2988, 2919, 2845 (C-H), 1729 (lactone C=O), 1640 (C=N), 1389 (N=C-S), 1327 (C-N), 1317 (N-N=C), 679 (C-S-C bend-ing); 1H NMR (400 MHz, DMSO–d6): δ 8.49 (s, 1H, –N=CH, benzimidazole), 8.21 (s, 1H, H–4, coumarin), 7.83-7.67 (m, 2H, Ar-H), 7.35-7.43 (m, 2H, coumarin), 7.32-7.17 (m, 2H, Ar-H), 7.05-7.12 (m, 2H, coumarin), 4.21 (s, 2H, S-CH2, thiadiazine), 3.71 (s, 2H, –N–CH2); 13C NMR (100 MHz, DMSO–d6): δ 168.1 (1C, C=O, coumarin), 165.2, 162.6 and 160.1 (3C, C-3, C-6 and C-9, triazolothiadiazine), 153.2 (1C, C-9, coumarin), 152.7 (1C, C–2, benzimidazole), 145.2-116.8 (13C, Ar-C), 43.8 (1C, N–CH2), 41.2 (1C, C-7, CH2, triazolothiadiazine). Found: C, 60.71; H, 3.58; N, 20.16. 3,3'-(7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-3,6- diyl)bis(2H-chromen-2-one) (2) Yield 68%, m.p. 245-257°C, IR (KBr, cm–1): 3058 (Ar-H), 2988, 2937, 2840 (C-H), 1734 (lactone C=O), 1633 (C=N), 1380 (N=C-S), 1331 (C-N), 1324 (N-N=C), 681 (C-S-C bending); 1H NMR (400 MHz, DMSO–d6): δ 8.34 (s, 1H, H–4, coumarin), 8.37 (s, 1H, H–4, coumarin), 7.29-7.46 (m, 4H, coumarin), 7.04-7.15 (m, 4H, coumarin), 4.27 (s, 2H, S-CH2, thiadiazine); 13C NMR (100 MHz, DMSO– d6): δ 169.1 (1C, C=O, coumarin), 167.8 (1C, C=O, coumarin), 166.1, 163.3 and 159.8 (3C, C-3, C-6 and C-9, triazolothiadiazine), 153.4 (1C, C-9, coumarin), 152.8 (1C, C-9, coumarin), 145.2-125.6 (14C, Ar-C), 41.9 (1C, C -7, CH2, triazolothiadia-zine). keywords: cancer; cell; ch2; compounds; coumarin; nmr; quinoline cache: bjp-22424.pdf plain text: bjp-22424.txt item: #289 of 942 id: bjp-22448 author: Khan, Arif; Khan, Rahmat Ali; Ahmed, Mushtaq; Mushtaq, Nadia title: In vitro antioxidant, antifungal and cytotoxic activity of methanolic extract of Calligonum polygonoides date: 2015 words: 3204 flesch: 56 summary: Eighty percent death rate of brine shrimp was observed at 1,000 μg/mL of plant extract. The ABTS (2,2, -azo-bis-(3-ethyl benzothiazoline-6-sulphonic acid) free 318 Bangladesh J Pharmacol 2015; 10: 316-320 Table I Survival and death of brine shrimps in the presence of various concentration of plant extract Concentration of plant extract (μg/mL) Total number of brine shrimps Survived brine shrimps % Survival % Death 50 10.0 ± 0.0 9.0 ± 1.0 90.0 ± 1.0 10.0 ± 0.0 100 10.0 ± 0.0 7.4 ± 1.2 70.0 ± 1.5 30.0 ± 0.5 250 10.0 ± 0.0 5.1 ± 1.0 50.4 ± 2.0 50.0 ± 0.9 500 10.0 ± 0.0 3.4 ± 1.6 30.2 ± 2.5 70.0 ± 0.5 1,000 10.0 ± 0.0 2.3 ± 1.8 20.1 ± 1.8 80.0 ± 0.8 Data are mean ± SD Table II Antifungal activity of Calligonum polygonoides methanolic extract (% inhibition) keywords: activity; anti; extract; methanolic; plant; polygonoides; scavenging cache: bjp-22448.pdf plain text: bjp-22448.txt item: #290 of 942 id: bjp-22463 author: Canli, Kerem; Altuner, Ergin Murat; Akata, Ilgaz title: Antimicrobial screening of Mnium stellare date: 2015 words: 3499 flesch: 53 summary: In this study, antimicrobial activity of Mnium stellare was determined against 17 bacterial and 1 fungal strains. Previous studies have shown that bryophytes produce a variety of secondary metabolites that present pharmaceutical activities including antimicrobial activity against various pathogenic bacteria and fungi. keywords: activity; altuner; antimicrobial; atcc; epidermidis; extracts; screening; stellare; study; subtilis cache: bjp-22463.pdf plain text: bjp-22463.txt item: #291 of 942 id: bjp-22471 author: Shoaib, Mohammad; Rahman, Ghawsur; Ali Shah, Syed Wadood; Umar, Mohammad Naveed title: Synthesis of 4-aminoantipyrine derived Schiff bases and their evaluation for antibacterial, cytotoxic and free radical scavenging activity date: 2015 words: 3289 flesch: 62 summary: They are reported for various pharmacological activities such as bacteriostatic (Karthikeyan et al., 2006), bactericidal (Metzler et al., 1980), antimalarial (Harpstrite et al., 2008), anti-oxidant activities (Thorat et al., 2012), antiviral (Maity et al., 2012), anti-pyretic (Kalaivani et al., 2012), antifungal (Cinarli et al., 2011), insecticidal (Patil et al., 2012), anti-tumor (Venkatesan et al., 2012) and anti-inflammatory (Shivarama et al., 2003). Burdulene D, Palaima A, Stumbryavichyute Z, Talaikite Z. Synthesis and anti-inflammatory activity of 4-aminoanti- pyrine derivatives of succinamides. keywords: activity; bases; ppm; schiff; synthesis cache: bjp-22471.pdf plain text: bjp-22471.txt item: #292 of 942 id: bjp-22473 author: Yu, Qi-Long; Tang, Zhao-Chun; Li, Jin-Ge; Wang, Guo-Liang; Wang, Pei-Jun; Pan, Zhao-Bao title: Anti-cancer and anti-angiogenesis effect of the leaf extract of Sargassum wightii against osteosarcoma cancer cells date: 2015 words: 4366 flesch: 54 summary: The coated HUVEC cells were then co-treated with various concentrations of ethanolic leaf extracts of S. wightii (100, 500 and 1000 μg/mL) and 20 ng/mL of VEGF solution. Upon adherence, the medium was replaced after 12 hours, and the cells were incubated with different concentrations (100, 500 and 1000 μg/ mL) of ethanolic leaf extracts of S. wightii followed by subsequent analysis by MTT assay. keywords: angiogenesis; cells; effect; extract; leaf; leaf extract; s. wightii; wightii cache: bjp-22473.pdf plain text: bjp-22473.txt item: #293 of 942 id: bjp-22546 author: Bajpai, Vivek K.; Sharma, Ajay; Baek, Kwang-Hyun title: Antibacterial mode of action of Ginkgo biloba leaf essential oil: Effect on morphology and membrane permeability date: 2015 words: 8631 flesch: 47 summary: The scanning electron microscopic analysis using G. biloba leaf essential oil showed considerable morphological alterations on the cell wall of tested pathogens. Scanning electron microscopic analysis To determine the efficacy of G. biloba leaf essential oil on the morphology of B. cereus ATCC 13061 and E. coli ATCC 43889, a scanning electron microscopic study was performed using the minimum inhibitory concentration of G. biloba leaf essential oil. keywords: 13061; atcc; atcc 13061; bacteria; biloba leaf; cell; cereus; cereus atcc; coli; coli atcc; concentration; effect; essential; food; g. biloba; membrane; oil cache: bjp-22546.pdf plain text: bjp-22546.txt item: #294 of 942 id: bjp-22576 author: Hussain, Liaqat; Akash, Muhammad Sajid Hamid; Tahir, Madeha; Rehman, Kanwal title: Hepatoprotective effects of Sapium sebiferum in paracetamol-induced liver injury date: 2015 words: 3067 flesch: 52 summary: The results of our present study are highly in consistent with the findings of several studies that have reported the hepatopro- tective effects of different plants including Carica papaya (Sadeque and Begum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Cocculus hirsutus (Thakare et al., 2009), Convolvulus arvensis (Ali et al., 2013), Dodonaea viscosa (Khan et al., 2013), Ipomoea staphylina (Bag and Mumtaz, 2013), Suaeda fruticosa (Rehman et al., 2013), Alcea rosea and Malva sylvestris (Hussain et al., 2014a,b), Trianthema decandra (Balamurugan and Muthusamy, 2008). Traditionally, the leaves of S. sebiferum are used for a number of ailments like ascites, eczema, shingles and snakebite (Fu et al., 2013). keywords: akash; effects; hepatoprotective; liver; paracetamol; sebiferum cache: bjp-22576.pdf plain text: bjp-22576.txt item: #295 of 942 id: bjp-22588 author: Lin, Feng; Peng, Yu-Hua; Yang, Qing-He; Mi, Xiu-Ju title: Resveratrol inhibits cadmium induced neuronal apoptosis by modulating calcium signalling pathway via regulation of MAPK/mTOR network date: 2015 words: 6967 flesch: 54 summary: Xie et al. (2010) has reported cadmium induced apoptosis as mediated by the release of Ca2+ from intracellular Ca2+ stores. Resveratrol exposure has also caused an obvious decrease in levels of intracellular release of Ca2+, suggesting its effect against cadmium induced release of Ca2+. keywords: akt; apoptosis; bapta; ca2+]i; cadmium; calcium; cell; chen; et al; exposure; levels; mapk; mtor; neurons; pharmacol; resveratrol; ros cache: bjp-22588.pdf plain text: bjp-22588.txt item: #296 of 942 id: bjp-22589 author: Sobiyi, Oluwakemi K.; Ashafa, A. O. Tom title: In vitro anthelmintic activity of Heliotropium indicum, Senna fistula and Spigelia anthelmia used as worm expeller in South West Nigeria date: 2015 words: 3630 flesch: 63 summary: Anthelmintic activity using Indian earthworms (Pheretima posthuma) The effect of the anthelmintic activity of S. anthelmia root is consistent with the report of Ezike et al. (2013), in which the whole plant methanol extract used against earthworm showed best potential anthelmintic effect of the three plants used for the study, he further claimed that the effect could be accounted for due to its alkaloids constituent as such compounds have been associated with anthelmintic activity (Makkaret al., 2007). keywords: activity; anthelmia; anthelmintic; extracts; indicum; plants; water cache: bjp-22589.pdf plain text: bjp-22589.txt item: #297 of 942 id: bjp-22598 author: Gupta, Randhir K.; Mishra, Anurag title: Diuretic activity of Coccinia grandis in rats date: 2015 words: 786 flesch: 59 summary: Diuretic activity of coccinia grandis in rats Sir, Coccinia grandis Linn (Family: Cucurbitaceae) is a climbing herb, growing wild throughout India. Shade dried fruits of C. grandis were powdered to get a coarse powder. keywords: grandis; urine cache: bjp-22598.pdf plain text: bjp-22598.txt item: #298 of 942 id: bjp-22602 author: Zhong, Jian; Hou, Jian-Quan title: A novel retinoic acid chalcone reverses epithelial-mesenchymal transition in prostate cancer cells date: 2015 words: 3292 flesch: 58 summary: Bangladesh Journal of Pharmacology Research Article A novel retinoic acid chalcone re-A novel retinoic acid chalcone re-A novel retinoic acid chalcone re- verses epithelial‑mesenchymal tran-verses epithelial‑mesenchymal tran-verses epithelial‑mesenchymal tran- sition in prostate cancer cellssition in prostate cancer cellssition in prostate cancer cells BJP Introduction Prostate cancer is the commonly diagnosed and second leading cause of death in men following the lung cancer in USA. These markers promote prostate cancer cells to undergo metastatic activity (Evdokimova, et al. 2012). keywords: cancer; cells; cwr22rv1; emt; expression; lps; prostate; rafc; treatment; vimentin cache: bjp-22602.pdf plain text: bjp-22602.txt item: #299 of 942 id: bjp-22619 author: lv, Jing; Cao, Ming-Qin; Yu, Jian-Chun title: Alantolactone pyrazoline analogue inhibits cancer cell proliferation and induces apoptosis in non-small cell lung carcinoma cells date: 2015 words: 3298 flesch: 57 summary: Apoptosis induction in cancer cells is also seen as a potent mechanism through which a wide variety of natural phytochemicals suppress cancer growth. Numerous natural phytochemicals have been reported to inhibit the growth of cancer cells through disruption of cell cycle progression (Chen and Kong, 2005; keywords: alantolactone; analogue; apa; apoptosis; cancer; cells; h460; lung; pyrazoline cache: bjp-22619.pdf plain text: bjp-22619.txt item: #300 of 942 id: bjp-22674 author: Sidana, Arushdeep; Farooq, Umar title: Evaluation of antileishmanial activity of plants used in Indian traditional medicine date: 2015 words: 1964 flesch: 49 summary: Bangladesh Journal of Pharmacology Research Article Evaluation of antileishmanial activity Evaluation of antileishmanial activity Evaluation of antileishmanial activity of plants used in Indian traditional of plants used in Indian traditional of plants used in Indian traditional medicinemedicinemedicine BJP Introduction Leishmaniasis is a current public health concern and is among the five parasitic diseases of high social impact world-wide (de Albuquerque Melo et al., 2014). Sidana A, Farooq U. Evaluation of antileishmanial activity of plants used in Indian traditional medicine. keywords: activity; compounds; extracts; plants cache: bjp-22674.pdf plain text: bjp-22674.txt item: #301 of 942 id: bjp-2276 author: Meenatchisundaram, Subramani; Priyagrace, Selvin; Vijayaraghavan, Ramasamy; Velmurugan, Ambikapathi; Parameswari, Govindarajan; Michael, Antonysamy title: Antitoxin activity of Mimosa pudica root extracts against Naja naja and Bangarus caerulus venoms date: 2009 words: 3190 flesch: 59 summary: Snake venoms and antivenoms: Critical supply issues. Development of simple standard assay procedures for the characterization of snake venoms. keywords: activity; cobra; edema; extracts; krait; naja; plant; pudica; venom cache: bjp-2276.pdf plain text: bjp-2276.txt item: #302 of 942 id: bjp-22805 author: Shahid, Sammia; Riaz, Tauheeda; Asghar, Muhammad Nadeem title: Screening of Ranunculus sceleratus for enzyme inhibition, antibacterial and antioxidant activities date: 2015 words: 5336 flesch: 52 summary: The FRAP values of the studied fractions were calculated and it was found that among all the fractions the ethyl acetate soluble fraction 440 Bangladesh J Pharmacol 2015; 10: 436-442 Table II Percentage inhibition of various fractions of R. sceleratus against Gram-positive and Gram-negative bacteria Samples %Inhibition S. typhi (+) E. coli (-) P. aeroginosa (-) B. subtilis (+) S. aerus (+) n-Hexane fraction 25.6 ± 0.5 27.3 ± 0.0 34.3 ± 1.1 35.8 ± 0.9 26.8 ± 0.3 Chloroform soluble fraction 60.4 ± 0.6 62.7 ± 0.8 70.6 ± 1.4 62.7 ± 3.8 58.2 ± 1.2 Ethyl acetate soluble fraction 72.3 ± 2.3 62.8 ± 2.4 71.6 ± 0.5 53.9 ± 2.6 64.2 ± 0.0 n-Butanol soluble fraction 61.7 ± 0.8 64.3 ± 0.6 74.4 ± 2.1 54.2 ± 2.6 63.8 ± 2.6 Remaining aqueous fraction 61.4 ± 0.9 67.9 ± 0.3 71.7 ± 0.6 59.4 ± 0.1 64.0 ± 1.4 Ciprofloxacina 90.5 ± 1.2 90.1 ± 0.4 92.3 ± 1.9 91.3 ± 2.0 93.1 ± 2.6 All results are presented as mean ± standard mean error of three assays; aStandard reference drug Table III MIC50 activities of various fractions of Ranunculus sceleratus against Gram-positive and Gram-negative Samples MIC 50 S. typhi (+) E. coli (-) P. aeroginosa (-) B. subtilis (+) S. aerus (+) n-Hexane fraction - - - - - Chloroform soluble fraction 10.4 ± 0.4 11.6 ± 0.3 7.1 ± 0.5 15.5 ± 0.7 12.0 ± 0.8 Ethyl acetate soluble fraction 10.8 ± 0.3 10.7 ± 0.2 7.8 ± 0.8 9.1 ± 0.1 10.8 ± 0.3 n-Butanol soluble fraction 10.4 ± 0.4 10.9 ± 0.6 5.6 ± 0.3 12.1 ± 0.4 11.2 ± 0.2 Remaining aqueous fraction 11.3 ± 0.3 10.7 ± 0.5 5.3 ± 0.4 9.1 ± 0.6 ± 10.5 ± 0.8 Ciprofloxacina 8.1 ± 0.2 8.2 ± 0.1 10.0 ± 0.1 9.0 ± 0.0 8.1 ± 0.2 Table IV IC50, total anti-oxidant activity, FRAP values, total phenolics and lipid peroxidation of Ranunculus sceleratus Sample IC50 µg/mL Chloroform soluble fraction 47.0 ± 1.0 0.8 ± 0.0 158.0 ± 1.1 73.3 ± 1.0 21.6 ± 0.9 Ethyl acetate soluble fraction 85.0 ± 0.6 1.0 ± 0.0 238.5 ± 1.1 97.1 ± 1.0 53.7 ± 1.6 n-Butanol soluble fraction 44.1 ± 0.8 1.0 ± 0.0 148.0 ± 0.9 79.6 ± 1.0 48.0 ± 1.5 Remaining aqueous fraction 81.5 ± 1.3 0.6 ± 0.0 46.0 ± 1.3 64.6 ± 0.5 18.2 ± 0.5 Ascorbic acida 58.9 ± 1.8 - - - - BHTa - 0.8 ± 1.2 - - 62.5 ± 1.1 Blank - - 20.4 16.5 - All results are presented as mean ± standard mean error of three assays. keywords: activity; anti; enzyme; fraction; ic50; inhibition; sceleratus; soluble cache: bjp-22805.pdf plain text: bjp-22805.txt item: #303 of 942 id: bjp-22844 author: Saleem, Hammad; Ahmad, Irshad; Gill, M. Shoaib Ali title: Phytochemical screening and diuretic activity of Euphorbia granulata date: 2015 words: 2800 flesch: 51 summary: Therefore, this study was designed to provide scientific evidence to the ethno- botanical uses of diuretic activity of crude aqueous methanol extract of E. granulata in normal albino rat model, and determine the toxicity and effects of E. granulate on excretion of urinary electrolytes. Abstract The aim of this study was to evaluate diuretic activity of aqueous methanolic extract of Euphorbia granulate in rats. keywords: activity; diuretic; extract; granulate; urine cache: bjp-22844.pdf plain text: bjp-22844.txt item: #304 of 942 id: bjp-22865 author: Li, Yong-Ji; Zhang, Ting; Tu, Jian-Xin; Li, Gang; Zhou, Yan title: Tangeretin inhibits IL-1β induced proliferation of rheumatoid synovial fibroblasts and the production of COX-2, PGE2 and MMPs via modulation of p38 MAPK/ERK/JNK pathways date: 2015 words: 5898 flesch: 47 summary: These results indicate that tange- Figure 4: Influence of tangeretin on IL-1 -induced protein expressions Tangeretin significantly reduced the IL-1 -induced raised expressions of MMPs and COX-2 following 24 hours (A and C) and 48 hours (B and D) of exposure. IL-1 -induced marked increases in the phosphorylation status and as well increased expressions of MAPK pathway proteins were regulat- ed by tangeretin at both the doses (50 and 100 µM) and at 24 hours (E and G) and 48 hours (F and H); L1-control; L2-IL-1 ; L3-tangeretin 50 µM; L4- tangeretin 100 µM; L5-IL-1 + tangeretin 50 µM; L6-IL-1 + tangeretin 100 µM; Values are represented as mean ± SD; n=3; *represents statistical significance at p<0.05 compared against control as determined by one-way ANOVA A B C Bangladesh J Pharmacol 2015; 10: 714-725 719 Figure 4: Influence of tangeretin on IL-1 -induced protein expressions (Cont.) keywords: arthritis; cells; cox-2; et al; expression; hours; il-1; p<0.05; pge2; pharmacol; production; proliferation; protein; rasfs; rheumatoid; tangeretin cache: bjp-22865.pdf plain text: bjp-22865.txt item: #305 of 942 id: bjp-22880 author: Saqib, Fatima; Janbaz, Khalid Hussain; Sherwani, Maryam Khan title: In vitro inhibitory potential of methanolic extract of Celosia argentea var. cristata on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes date: 2015 words: 3809 flesch: 57 summary: Eserine 0.5 mM - 91.3 ± 1.2 82.8 ± 1.1 - 0.0 ± 0.0 0.9 ± 0.0 Kojic acid 0.5 mM 93.5 ± 0.9 - - 6.0 ± 0.1 - - All experiments are performed in triplicate and represented as mean± SEM; Standard drugs used are Kojic acid for tyrosinase inhibition and eserine for AChE and BChE inhibition K ojic A ci d(0 .5 m M ) Anti-oxidant activity also affect tyrosinase activity (Kim et al., 2008). keywords: acetylcholinesterase; activity; anti; argentea; argentea var; celosia; cristata; extract; inhibition; tyrosinase; var cache: bjp-22880.pdf plain text: bjp-22880.txt item: #306 of 942 id: bjp-22992 author: Alam, Fiaz; Saqib, Qazi Najam us; Waheed, Abdul title: Cytotoxic activity of crude saponins from Gaultheria trichophylla against human breast cancer cells MCF-7 and MDA-MB-468 date: 2015 words: 3453 flesch: 58 summary: This was a clear indication of apoptosis Bangladesh J Pharmacol 2015; 10: 443-448 445 Table I Dose-dependent growth inhibition of cancer cell lines by crude extract of Gaultheria trichophylla Concentration (µg/mL) MTT assay NRU assay %Growth inhibition %Growth inhibition MCF-7 cells MDA MB-468 cells MCF-7 cells MDA MB-468 cells 10 22.1 ± 5.9a 9.4 ± 4.9 29.0 ± 6.1a 30.1 ± 3.2b 25 24.7 ± 7.1a 15.8 ± 5.4a 33.0 ± 5.3b 43.9 ± 3.4b 50 41.6 ± 3.8b 38.4 ± 6.3b 44.1 ± 3.6b 46.0 ± 4.2b 100 40.0 ± 3.4b 46.2 ± Results The results from the MTT and NRU assays of cellular viability in various concentrations of methanolic crude extract (G.Me) of G. trichophylla are listed in Table I. MCF-7 and MDA MB-468 cells were inhibited by crude extract with a rate increasing with increasing concentration. keywords: assay; cancer; cells; crude; mb-468; mcf-7; mda; saponins; trichophylla cache: bjp-22992.pdf plain text: bjp-22992.txt item: #307 of 942 id: bjp-23016 author: Zhou, Jian-Bo; Peng, Gang; Jia, Yu-Cheng; Li, Jun; Wang, Jia; Nie, Shu; Zhang, Qiu-Ying title: Inhibition of β-catenin protein expression by triptolide affects self-renewal of liver cancer stem cells date: 2015 words: 3427 flesch: 55 summary: Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. A group of cells possessing stem cell properties and ability of propagating and sustaining tumors are known as cancer stem cells (CSCs) (Mackillop et al., 1983; Gupta et al., 2009). keywords: cancer; catenin; cd133; cells; lcscs; stem; triptolide cache: bjp-23016.pdf plain text: bjp-23016.txt item: #308 of 942 id: bjp-23018 author: Li, Hu; Xu, Yan; Yang, Li; He, Lei title: Tanshinone IIA inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway date: 2015 words: 3512 flesch: 57 summary: It was observed that tanshi- none IIA induces death in cervical cancer cells through the mitochondrial apoptotic pathway. Tanshinone IIA inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway Hu Li1, Yan Xu1, Li Yang1 and Lei He2 1Department of Gynecology, Panyu Central Hospital, Guangzhou, 511400, China; 2Department of Neurology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 511400, China. keywords: akt; apoptosis; cancer; cells; hours; iia; sw756; tanshinone; tanshinone iia; treatment cache: bjp-23018.pdf plain text: bjp-23018.txt item: #309 of 942 id: bjp-23039 author: Li, Jian-Ming; Li, Wu-Yin; Huang, Man-Yu; Zhang, Xiao-Qiang title: Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells date: 2015 words: 5970 flesch: 53 summary: Present study investigates whether fisetin induces apoptosis of human osteosarcoma cells and modulats the MAPK and PI3/Akt signalling pathways. These findings indicate that fisetin induces apoptosis in human osteosarcoma cells by activating caspase cascades. keywords: activation; akt; apoptosis; cancer; cells; et al; fisetin; hours; jnk; osteosarcoma; p38; pathway; pi3k; proteins; regulation; ros; u-2 cache: bjp-23039.pdf plain text: bjp-23039.txt item: #310 of 942 id: bjp-23063 author: Saleem, Mohammad; Naseer, Faiza; Hussain, Khalid; Alamgeer, - title: Cytotoxic effect of methanol extract of Conyza bonariensis on DMBA-induced skin carcinogenesis: An in vivo study date: 2015 words: 4891 flesch: 57 summary: Many plants like Convolvulous arvensis (Saleem at al, 2014), Catharanthus roseus (Cragg and Newman, 2005; Okouneva et al., 2003; Simeons et al., 2008), Podophyllum peltatum and Podophyllum emodi (Shoeb et al., 2006), Taxus brevifolia Nutt, Taxus baccata (Kingston, 2007; Hait et al., 2007), Camptotheca acuminate (Zhang et al., 2004, Fuchs et al., 2006), Berberis amarensis (Xie et al., 2009; Xu et al., 2006), Hvdrastis canadensis L (Wang et al., 2011; Patil et al., 2010), Tabebuia avellanedae (Li et al., 2000; De Almeida, 2009), Betula alba (Fulda, 2008), Colchicum autumnale (Dubey et al., 2008), Curcuma longa (Sa et al., 2010; Goel et al., 2008), Wikstroemia indica (Lu et al. 2011; It is a potent bioactive molecule that possess anticarcinogenic potential since it can interfere with the initiation, development and progression of cancer by the modulation of cellular proliferation, differentiation, apoptosis, angiogenesis and metastasis (Kumar et al., 2011). keywords: bonariensis; croton; dmba; et al; extract; group; methanol; mice; oil; skin; tumor; week cache: bjp-23063.pdf plain text: bjp-23063.txt item: #311 of 942 id: bjp-23068 author: Rather, Irfan Ahmad; Choi, Kwang-Ho; Bajpai, Vivek K.; Park, Yong-Ha title: Antiviral mode of action of Lactobacillus plantarum YML009 on Influenza virus H1N1 date: 2015 words: 5049 flesch: 51 summary: In brief, L. plantarum YML009 was incubated in MRS broth with pH 2.5, and 1N HCl was then added to a final concentration of 1%. Hemolytic phenomenon test For hemolytic activity test, L. plantarum YML009 was cultured in MRS broth and then streaked on tryptone soya agar (Oxoid) with an addition of 5% sheep blood. keywords: activity; cell; h1n1; influenza; lactobacillus; plantarum; strain; virus; yml009 cache: bjp-23068.pdf plain text: bjp-23068.txt item: #312 of 942 id: bjp-23076 author: Wang, Jing Yao; Zhang, Nan; Yang, Xiaojie; Gao, Danli; Yin, Lirong; Ji, Shuying title: MHC class I-presented tumor antigen appraisable for T-cell responses against ovarian cancer date: 2015 words: 3384 flesch: 57 summary: Liu JJ, Lin B, Hao YY, Li FF, Liu DW, Qi Y, Zhu LC, Zhang SL, Iwamori M. Lewis(y) antigen stimulates the growth of ovarian cancer cells via regulation of the epidermal growth factor receptor pathway. Meng CF, Su B, Li W. DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. keywords: antigen; cancer; cell; grade; hla; mhc; patients; peptide; reactions; tumor cache: bjp-23076.pdf plain text: bjp-23076.txt item: #313 of 942 id: bjp-23079 author: Du, Zhenhua; Ma, Xiaolin title: Dose-dense weekly paclitaxel and carboplatin compared with conventional paclitaxel and carboplatin treatment for stage II-IV ovarian cancer patients date: 2015 words: 3217 flesch: 47 summary: Conventional chemothe-rapy regimens of epithelial ovarian cancer is the combine chemotherapy based on platinum, in the platinum, cisplatin and carboplatin have a similar curative effect, but the adverse reaction is different, as neurotoxicity adverse reaction of cisplatin overlap paclitaxel, but the renal toxicity, gastrointestinal reaction and neurotoxi- city of carboplatin are all less than cisplatin, so the ovarian cancer treatment guidelines make by most of the gynecological cancer center and authority of the gynecological tumors, recommend paclitaxel and carbo- A Journal of the Bangladesh Pharmacological Society (BDPS) In conclusion, these results of our study displayed that PFS of dose-dense weekly paclitaxel and carboplatin is associated with longer than a conventional regimen of paclitaxel and carboplatin in epithelial ovarian cancer. keywords: cancer; carboplatin; carboplatin group; dose; group; ovarian; paclitaxel; patients; treatment cache: bjp-23079.pdf plain text: bjp-23079.txt item: #314 of 942 id: bjp-23093 author: Mushtaq, Muhammad Naveed; Akhtar, Muhammad Shoaib; ., Alamgeer title: Blood pressure lowering effect of Pennisetum glaucum in rats date: 2015 words: 3492 flesch: 63 summary: Table I Effects of aqueous-methanolic extract of Pennisetum glaucum seeds on blood pressure and heart rates in normotensive rats Time (hour) Treatment with extract of Pennisetum glaucum seeds 250 mg/kg 500 mg/kg 1,000 mg/kg SBP MBP DBP HR SBP MBP DBP HR SBP MBP DBP HR 0 127.1 (0.6) 102.9 (0.3) 90.7 (0.6) 384 (2.0) 124.8 (0.5) 106.8 (0.8) 97.7 (1.3) 378 (2.1) 127.1 (0.7) 105.6 (0.8) 94.7 (1.1) 387 (2.1) 2 125.1 (0.5) 101 (0.4) 88.9 (0.8) 383 (1.0) 120.4 (2.1) 100.4 (0.4) 90.4 (0.7) 373 (1.5)a 121.4 (2.1)a 99.0 (1.7) 87.7 (3.1) 373 (2.4)a 4 124.5 (0.9) 99.6 (0.7) 87.2 (1.0) 382 (1.3) 118 (0.4) 94.3 (1.0)a 82.0 (1.7)a 366 (2.2)b 112.7 (2.1)b 91.5 (1.5)a 80.1 (2.7)a 357 (4.4)b 6 123.2 (1.2) 98.5 (1.7) 86.1 (2.8) 381 (1.8) 116.7 (1.7)a 85.0 (1.8)b 69.0 (1.0)c 354 (2.6)b 104.2 (2.4)c 86.6 (1.4)b 77.9 (2.5)b 341 (3.1)c 8 125.6 (0.6) 101 (0.8) 88.8 (1.1) 383 (0.9) 121.4 (0.7)a 91.0 (2.1)a 75.0 (3.0)b 359 (2.3)b 101.5 (2.0)c 83.6 (1.5)c 74.6 (2.7)c 332 (2.7)c Results are expressed as means (S.E.M); n = 6; SBP means systolic blood pressure; MBP means mean blood pressure; DBP means diastolic blood pressure; HR means heart rate; a = (p<0.05), b = (p<0.01), c = (p<0.001) vs. control (0 h) Table II Effects of aqueous-methanolic extract of Pennisetum glaucum seeds on blood pressure and heart rates in glucose-induced hypertensive rats Time (hour) Treatment with extract of Pennisetum glaucum seeds 250 mg/kg 500 mg/kg 1,000 mg/kg SBP MBP DBP HR SBP MBP DBP HR SBP MBP DBP HR 0 160.0 (2.2) 141.0 (0.7) 133.0 (0.9) 396 (4.0) 166 (0.8) 155.0 (0.7) 150.0 (0.8) 398 (3.8) 165.4 (2.0) 144.0 (0.6) 133.0 (0.8) 400 (2.3) 2 154.3 (1.0) 140.9 (0.6) 131.0 (0.8) 383 (2.6)a 150.5 (1.2) 143.0 (0.6) 139.0 (0.7) 386 (4.1)a 145.0 (3.2)a 129.0 (2.4)b 121 (2.5)a 371 (3.7)b 4 151.1 (1.6) 130.0 (1.5)a 120.0 (1.8) 376 (3.7)b 143.0 (1.8)a 137.3 (1.2)a 134.0 (1.1) 360 (2.7)b 132.0 (2.6)b 109.4 (1.8)c 98.0 (1.1)b 363 (3.1)c 6 141.0 (1.8)b 124.0 (3.5)b 116.0 (0.7) 363 (2.1)b 139.0 (2.8)a 130.0 (2.5)b 125.0 (0.7)a 350 (4.2)b 123.4 (1.3)c 97.0 (1.2)c 84.0 (2.5)b 340 (4.2)c 8 138.0 (1.0)b 126.0 (2.6)b 120.0 (1.9) 367 (4.0)b 130.0 (2.3)b 122.0 (2.2)c 118.0 (1.1)b 348 (3.2)b 119.4 (1.2)c 89.4 (1.0)c 74.4 (3.1)c 327 (3.2)c Results are expressed as means (S.E.M); n = 6; SBP means systolic blood pressure; MBP means mean blood pressure; DBP means diastolic blood pressure; HR means heart rate; a = (p<0.05), b = (p<0.01), c = (p<0.001) vs. control (0 h) 496 Bangladesh J Pharmacol 2015; 10: 494-499 and low costs (Khanet al., 2014). The extract significantly (p˂0.5 - p˂0.001) decreased blood pressure and heart rate with maximum effect at 1,000 mg/kg dose. keywords: blood; extract; glaucum; glucose; heart; pressure; rate; rats; seeds cache: bjp-23093.pdf plain text: bjp-23093.txt item: #315 of 942 id: bjp-23095 author: Chen, Da; Zhang, Xiao-Yi; Zheng, Fa-Zhu; Wang, Hai-Tao; Cai, Jian-Liang; Xia, Ming title: Induction of cell death in prostate cancer cells by escopoletin, a promising treatment strategy date: 2015 words: 2213 flesch: 50 summary: Analysis of the presence G1 phase marker in DU145 cells showed significantly higher concentration Figure 2: Induction of cell death and ROS generation in prostate cancer cells by escopoletin. The results revealed a significantly higher cytotoxicity by escopoletin that caused cell death in DU145 cells. keywords: cancer; cells; death; du145; escopoletin; prostate; ros; treatment cache: bjp-23095.pdf plain text: bjp-23095.txt item: #316 of 942 id: bjp-23101 author: Knapik-Czajka, Malgorzata Elzbieta title: Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats date: 2015 words: 4406 flesch: 56 summary: Ball MR, Gumaa KA, McLean P. Effect of clofibrate on the CoA thioester profile in rat liver. Dietary thiamin level influences levels of its diphosphate form and thiamine-dependent enzymic activi- ties of rat liver. keywords: activity; bezafibrate; complex; control; fenofibrate; fibrates; levels; liver; low; mrna; ogdh; protein; rats cache: bjp-23101.pdf plain text: bjp-23101.txt item: #317 of 942 id: bjp-23189 author: Paul, Issac; Mundugaru, Ravi; Prakash, Narayana; Basavaiah, Ravishankar title: Anxyiolytic activity of fortified Centella asciatica date: 2015 words: 1679 flesch: 58 summary: Evaluation of drug activities. The dose of fortified form of C. asiatica for anti anxiety activity in human is 6 g. The dose for the rat and mice were calculated on the basis of body surface area ratio by referring to the standard table of Paget and Barnes (Pagets et and Barnes, 1964). keywords: activity; control; group; number; test cache: bjp-23189.pdf plain text: bjp-23189.txt item: #318 of 942 id: bjp-23192 author: Khan, Arif; Khan, Rahmat Ali; Khalil, Tanzila title: Antimicrobial activities of Calligonum polygonoides, Albezia lebeck and Piper nigrum date: 2015 words: 720 flesch: 48 summary: The antibacterial potency of various fractions of C. polygonoides methanol extracts were carried out through protocol of Bagamboula et al., (2003) against Staphylococcus aureus and Escherichia coli. These evidences provide us a platform to screen various medicinal plants for their bioactive natural products and active metabolites (Suffredini et al., 2004). keywords: lebeck; nigrum; polygonoides cache: bjp-23192.pdf plain text: bjp-23192.txt item: #319 of 942 id: bjp-23196 author: Tang, Jun; Zhao, Juan-Juan; Li, Zhi-Hong title: Ethanol extract of Artemisia sieversiana exhibits anticancer effects and induces apoptosis through a mitochondrial pathway involving DNA damage in COLO-205 colon carcinoma cells date: 2015 words: 3125 flesch: 46 summary: Morphological changes induced by A. sieversiana extract in COLO-205 colon cancer cells detected by phase contrast microscopy: Since COLO-205 cancer cells were the most affected among the different tested colon cancer cells. The results are shown in Figure 4, which indica- tes that the extract induced a dose-dependent loss of MMP in COLO-205 cancer cells. keywords: cancer; cells; colo-205; colon; dna; extract; sieversiana cache: bjp-23196.pdf plain text: bjp-23196.txt item: #320 of 942 id: bjp-23225 author: Saad Ur Rehman, Muhammad; Hafeez Kamran, Sairah; Ahmad, Mobasher; Akhtar, Usman title: Anti-diabetic activity of crude Pistacia lentiscus in alloxan-induced diabetes in rats date: 2015 words: 2705 flesch: 58 summary: For acute study, rats were divided into four groups of five rats each; group I (normal rats); group II (diabetic untreated rats); group III (diabetic treated with standard drug glibenclamide); group IV (diabetic treated with crude Pistacia gum 100 mg/kg). For chronic study, rats were divided into four groups of five rats each; Group I (normal rats); Group II (diabetic untreated rats); Group III (diabetic treated with glibenclamide); Group IV (diabetic treated with crude Pistacia gum 100 mg/kg). keywords: days; diabetic; extract; gum; lentiscus; pistacia; plate; rats cache: bjp-23225.pdf plain text: bjp-23225.txt item: #321 of 942 id: bjp-23260 author: Yu, Bo; Jiang, Yu; Liu, Yue; Ma, Tonghui; Yang, Hong title: Prevention of secretory diarrhea by ethanol extract of Bistortae rhizoma through inhibition of chloride channel date: 2015 words: 4672 flesch: 41 summary: Chao AC, de Sauvage FJ, Dong YJ, Wagner JA, Goeddel DV, Gardner P. Activation of intestinal CFTR Cl-channel by heat- stable enterotoxin and guanylin via cAMP-dependent pro- tein kinase. Results indicated that D5 inhibited CFTR chloride channel in a dose-dependent way (IC50=42.4 μg/mL). keywords: ano1; cacc; cells; cftr; channel; chloride; figure; fluid; fluorescence; inhibition; rhizoma; secretion cache: bjp-23260.pdf plain text: bjp-23260.txt item: #322 of 942 id: bjp-23264 author: Zhang, Jun-Fei; Liu, Bo; Chen, Cong-Xin title: Dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives as potent and selective inhibitors targeting hepatitis B virus date: 2015 words: 4223 flesch: 62 summary: By structural biology, we established a screening system for anti-HBV compounds that target on nucleocapsid. Compounds 4a, 4b, 4c, 4f, 4n, and 4m displayed good to better anti HBV activity. keywords: compounds; dihydroisoindolo[2,1; dione; hbv; mhz; nmr cache: bjp-23264.pdf plain text: bjp-23264.txt item: #323 of 942 id: bjp-23269 author: Khan, Arif; Khan, Rahmat Ali; Ahmed, Mushtaq; Mushtaq, Nadia title: Antioxidant and antifungal activities of selected fruits of Districts Bannu and Lakki Marwat, Pakistan date: 2015 words: 772 flesch: 46 summary: I DPPH free radicals scavenging activity of fruit methanol extracts Concentration Free radicals scavenging activity (mean ± SD) Archis hypogea Phoenix dactylifera Vitis vinifera Ascorbic acid 50 μg/mL 16.1 ± 0.2 21.1 ± 0.2 22.4 ± 0.1 52.0 ± 0.0 100 μg/mL 28.0 ± 0.1 42.0 ± 0.1 32.0 ± 0.2 72.0 ± 0.1 150 μg/mL 42.0 ± 0.1 56.0 ± 0.1 48.2 ± 1.0 80.0 ± 0.0 200 μg/mL 52.0 ± 0.1 64.0 ± 0.0 56.0 ± 0.1 83.0 ± 0.0 250 μg/mL 62.0 ± 0.0 70.1 ± 0.2 65.0 ± 0.0 86.1 ± 0.0 500 μg/mL 72.0 ± 0.0 79.0 ± 0.0 76.1 ± 0.0 90.1 ± 0.1 Table II Antifungal activity of methanol extract of Archis hypogeal, Phoenix dactylifera and Vitis vinifera % inhibition Aspergillus niger Aspergillus flavius keywords: activity; vinifera cache: bjp-23269.pdf plain text: bjp-23269.txt item: #324 of 942 id: bjp-23361 author: Chandran, Rahul; Sathyanarayanan, Saikumar; Rajan, Murugan; Kasipandi, Muniyandi; Parimelazhagan, Thangaraj title: Anti-oxidant, hypoglycemic and anti-hyperglycemic properties of Syzygium calophyllifolium date: 2015 words: 5515 flesch: 55 summary: Anti-oxidant activity of water extract of harng Jyur (Chrysanthemum morifolium Ramat). Toxicol Appl Pharmacol. 2006; 212: 167–78 Siddhuraju P, Becker K. Studies on anti-oxidant activities of Mucuna seed (Mucuna pruriens var. keywords: activity; anti; bark; calophyllifolium; extract; glucose; leaf; methanol; radical; scavenging cache: bjp-23361.pdf plain text: bjp-23361.txt item: #325 of 942 id: bjp-23362 author: Khan, Rahmat Ali; Khan, Muhammad Rashid; Khan, Arif title: Comparative antioxidant scavenging and lipid peroxidation activity of rutin and gallic acid date: 2015 words: 1199 flesch: 44 summary: 638 Bangladesh J Pharmacol 2015; 10: 637-638 1 5 10 25 50 100 0 50 100 150 R T GA C o n ce n tra tio n (g / m l) D P P H % s c a v e n g in g 50 100 150 200 250 300 0 50 100 150 RT GA Concentration (g / ml) S u p er o x id e % s ca v en g in g Figure 1: DPPH and superoxide scavenging activity rutin (RT) and gallic acid (GA) mailto:mrkhanqau@yahoo.com Results showed that rutin (IC50 6.7 ± 0.1 µg/mL) possessed highest antioxidant activity as compared to gallic acid (19.0 ± 0.0 µg/mL) (Table I; Figure 1). keywords: acid; activity; gallic; rutin; scavenging cache: bjp-23362.pdf plain text: bjp-23362.txt item: #326 of 942 id: bjp-23381 author: Husain, Asif; Varshney, Munendra M.; Parcha, Versha; Ahmad, Aftab; Khan, Shah Alam title: Synthesis and biological evaluation of new hydrazide-Schiff bases date: 2015 words: 5187 flesch: 62 summary: Anthelmintic activity The helminthes are the common cause of parasitic diseases in poverty stricken and developing countries with warm, moist environments with poor sanitary conditions (Sarnaim et al., 2013). The possible mecha- nism of anthelmintic activity of these compounds could be due to their ability to provide two potential donor sites viz. keywords: activity; antibacterial; bases; compounds; conh; schiff; synthesis cache: bjp-23381.pdf plain text: bjp-23381.txt item: #327 of 942 id: bjp-23402 author: Nasrin, Fatema; Hakim, Md. Lukman title: In vivo antidiarrheal study of ethanolic extracts of Mikania cordata and Litsea monopetala leaves date: 2015 words: 3060 flesch: 58 summary: Neuropharmacologi- cal studies on Mikania cordata root extract. Mandal PK, Bishayee A, Chatterjee M. Stimulation of tissue repair by Mikania cordata root extract in carbon tetrachloride- induced liver injury in mice. keywords: activity; cordata; extract; leaves; mikania; monopetala cache: bjp-23402.pdf plain text: bjp-23402.txt item: #328 of 942 id: bjp-23406 author: Hussain, Musaddique; Raza, Shahid Masood; Janbaz, Khalid Hussain title: Pharmacologically mechanistic basis for the traditional uses of Rumex acetosa in gut motility disorders and emesis date: 2015 words: 4922 flesch: 57 summary: Electrically grinded coarse powdered material (#40) was subjected to triple maceration (Hussain et al., 2013), with 70% methanol-aqueous mixtures to produce the methanolic extract of R. acetosa; named Ra. It has been previously observed that spasmolytic effect of medicinal plants is usually mediated through Ca2+ channels blockade (Janbaz et al., 2012; Hussain et al., 2014). keywords: acetosa; effect; extract; methanolic; pharmacol cache: bjp-23406.pdf plain text: bjp-23406.txt item: #329 of 942 id: bjp-23414 author: Xu, Qian; Cao, Kai; Xiao, Yan-Hong; Du, Chao; Dong, Xian-Hui; Wang, Yu; Zhou, Xiao-Hui title: Effects of paeonol on the expression of NF-κB pathways in human umbilical veins endothelial cells induced by homocysteine date: 2015 words: 3847 flesch: 54 summary: Compared with normal control group, △p<0.01; Compared with homocysteine injured model group, *p<0.01;Normal: normal control group; Model: Homocysteine injured model group; L-Pae: low- dose group of paeonol; M-Pae: middle-dose group of paeonol; H-Pae: high-dose group of paeonol mRNA expression in the low-dose, the middle-dose and the high-dose group of paeonol was remarkably lower than that of homocysteine model group (p<0.05, p<0.01) and they were in a dose-dependent manner (p<0.05) (Figure 2). Normal control group cells are maintained in DMEM supplemented with 10%(v/v) fetal calf serum. keywords: control; dose; dose group; expression; group; homocysteine; model; paeonol cache: bjp-23414.pdf plain text: bjp-23414.txt item: #330 of 942 id: bjp-23444 author: Ullah, Rafi; Bakht, Jehan; Shafi, Mohammad title: Antimicrobial and anti-oxidant potential of Periploca hydaspidis date: 2015 words: 4503 flesch: 52 summary: The order of antiradical scaven- ging potential of different extracted samples of the stem was crude methanolic extract>butanol> ethylacetate> water>n-hexane at different concentrations. One part (10 g) was used as crude methanolic extract and the second part (80 g) was used for further fractionation with different solvents. keywords: acetate; activity; butanol; concentration; crude; ethyl; extracts; fractions; hexane; methanolic; samples cache: bjp-23444.pdf plain text: bjp-23444.txt item: #331 of 942 id: bjp-23446 author: Rahman, Shafiq ur; Ismail, Muhammad; Shah, Muhammad Raza; Iriti, Marcello; Shahid, Muhammad title: GC/MS analysis, free radical scavenging, anticancer and beta-glucuronidase inhibitory activities of Trillium govanianum rhizome date: 2015 words: 4724 flesch: 52 summary: The phytochemical analysis of rhizome revealed the presence of secondary metabolites like steroids, glycol- sides and saponins, and these metabolites have been previously reported in the genus Trillium (Akihito and Bangladesh J Pharmacol 2015; 10: 577-583 581 Figure 2: DPPH free radical scavenging activity of extracts/fractions or standards (ascorbic acid and BHT). A lot of research has been conducted on exploring the phytochemical and pharmacological characteristics of medicinal plants to provide a scientific rationale to their folkloric uses (Adonizio et al., 2008; Saeed et al., 2010). keywords: acid; activity; cancer; cells; et al; fatty; fraction; govanianum; methanol; plants; test cache: bjp-23446.pdf plain text: bjp-23446.txt item: #332 of 942 id: bjp-23486 author: Aslan, Abdullah; Boydak, Didem; Can, Muhammed Ismail; Kuloglu, Tuncay title: Nigella sativa improves the carbon tetrachloride-induced lung damage in rats through repression of erk/akt pathway date: 2015 words: 4220 flesch: 54 summary: Even though the weight increase in the CCl4 + N. sativa group is lower in comparison with that of the control groups, a higher weight increase has been observed in comparison with the CCl4 group. In addition, caspase-9 expression increased in the CCl4 + N. sativa group in comparison with the CCl4group (Figure 1B). keywords: ccl4; control; effects; group; lung; protein; rats; sativa; water cache: bjp-23486.pdf plain text: bjp-23486.txt item: #333 of 942 id: bjp-23496 author: Tan, Juan; Shenghua, Li; Zeng, Junying; Wu, Xianjin title: Anti-oxidant and hepatoprotective activities of total flavonoids of Indocalamus latifolius date: 2015 words: 6942 flesch: 56 summary: The results showed that in vitro hepatoprotective and anti-oxidant activities of total flavonoids at doses of 200 and 400 mg/kg and 100 mg/kg, respectively, were comparable to those of the known hepatoprotective drug silymarin at 100 mg/kg. Anti-oxidant activity in a linoleic acid system using ferric thiocyanate and thiobarbituric acid The ferric thiocyanate (FTC) test was conducted as described by Osawa and Namiki (Osawa and Namaki, 1981), with slight modifications. keywords: absorbance; acid; activities; activity; anti; ccl4; column; control; flavonoids; group; mixture; radical; scavenging; solution cache: bjp-23496.pdf plain text: bjp-23496.txt item: #334 of 942 id: bjp-23500 author: Göger, Fatih; Köse, Yavuz Bülent; Göger, Gamze; Demirci, Fatih title: Phytochemical characterization of phenolics by LC-MS/MS and biological evaluation of Ajuga orientalis from Turkey date: 2015 words: 3654 flesch: 55 summary: Additionally phytochemical studies of the extract, in vitro antimicrobial activity was evaluated seven different strains in this study (Table II) using micro- dilution methods. Antioxidant, antimicrobial activities and characterization of phenolic compounds from buriti Mauritia flexuosa L. by UPLC–ESI-MS/MS. keywords: activity; ajuga; antioxidant; compound; extract; orientalis; radical cache: bjp-23500.pdf plain text: bjp-23500.txt item: #335 of 942 id: bjp-23565 author: Qian, Yu-Xian; Yu, Rui; Qin, Shi-Rong title: Paclitaxel and trastuzumab treatment affects insulin growth factor I expression in breast cancer cell lines date: 2015 words: 4073 flesch: 59 summary: Bangladesh Journal of Pharmacology Research Article Paclitaxel and trastuzumab treatment affects insulin growth factor I expres- sion in breast cancer cell lines BJP Introduction Insulin-like growth factor I receptor (IGF-1R) is a recep- tor tyrosine kinase (RTK) protein overexpressed (about 70%) in breast cancer cells (Nielson et al., 2004; Sachdev et al., 2004). 800 Bangladesh J Pharmacol 2015; 10: 799-806 Results Down-regulation of IGF-1Rb, IRS-2, PI3K and up- regulation of IGFBP-3 and PTEN by drug treatment The important phenotypic characteristics of metastatic phase in breast cancer cells are regulated by IGF system which included survival, growth and metastasis (Figueroa and Yee, 1992). keywords: breast; cancer; cells; drug; expression; growth; igf-1; paclitaxel; t47d; trastuzumab; treatment cache: bjp-23565.pdf plain text: bjp-23565.txt item: #336 of 942 id: bjp-23572 author: Liu, Li-Wei; Zhu, Li-Xin; Liu, Bo title: Expression of microRNA-132 in patient with liver cancer and mediation of microRNA-132 on cell growth of liver cancer cell date: 2015 words: 3080 flesch: 49 summary: Abstract We detected the expression of microRNA-132 in Chinese patient with liver cancer and evaluated down-regulation of microRNA-132 affect on cell growth and apoptotic of liver cancer cell. Down-regulation of microRNA-132 could inhibit cell growth and activated apoptotic of liver cancer cell. keywords: cancer; cancer cell; cell; expression; liver; liver cancer; microrna-132; patients; wang cache: bjp-23572.pdf plain text: bjp-23572.txt item: #337 of 942 id: bjp-23575 author: Zhang, Huawei; Ruan, Chuanfeng; Bai, Xuelian title: Isolation and antimicrobial effects of endophytic fungi from Edgeworthia chrysantha date: 2015 words: 2182 flesch: 52 summary: This was the first report on isolation and evaluation of antimicrobial effect of endophytic fungi from E. chrysantha. This was the first report on the isolation and antimicrobial effects of endophytic fungi from E. chrysantha. keywords: + +; broth; chrysantha cache: bjp-23575.pdf plain text: bjp-23575.txt item: #338 of 942 id: bjp-23578 author: Majeed, Wafa; Khaliq, Tanweer; Aslam, Bilal; Khan, Junaid Ali; Iftikhar, Asra title: Medicinal plants with gastroprotective potential date: 2015 words: 11650 flesch: 46 summary: These indicators are altered considerably by using plant extracts. Phytoche- mical investigations had revealed the presence of carbohydrates, proteins, tannins, triterpenes and amino acids in plant extract which might be responsible for antioxidant and antiulcer potential of methanolic seed extract of B. hispida. keywords: acid; activity; antioxidant; antiulcer; antiulcer activity; constituents; dose; et al; extract; gastric; gastroprotective; gastroprotective activity; leaf; leaf extract; lesions; methanolic; plant; plant extract; potential; presence; rats; results; study; ulcer cache: bjp-23578.pdf plain text: bjp-23578.txt item: #339 of 942 id: bjp-23580 author: Li, Da-Wei; Meng, Long; Zhang, Kui-Xing; Zhang, Wei-Ke title: Anticancer and apoptotic effects of theaflavin-3-gallate in non-small cell lung carcinoma date: 2015 words: 4891 flesch: 54 summary: B, C and D represent cells treated with 20, 80 and 160 µM dose of theaflavin-3-gallate 794 Bangladesh J Pharmacol 2015; 10: 790-798 Figure 4: Effect of theaflavin-3-gallate on cell cycle phase distribution in A-549 non-small cell lung cancer cells. Epidemiology of lung cancer: Figure 7: Theaflavin-3-gallate decreases invasion of A-549 non-small cell lung cancer cells. keywords: a-549; apoptosis; cancer; cells; control; figure; gallate; hours; lung; theaflavin-3; treatment cache: bjp-23580.pdf plain text: bjp-23580.txt item: #340 of 942 id: bjp-23600 author: Ahmed, Sarfaraz; Mothana, Ramzi A.; Al-Rehaily, Adnan J. title: In vivo hypoglycemic and anti-diabetic study of Oncocalyx glabratus date: 2015 words: 3432 flesch: 54 summary: Conversely ethyl acetate extract decrease VLDL-C and LDL-C percentage by 32% and 30% respectively and methanol extract decrease VLDL-C and LDL-C percentage by 36% and 50% respectively. A number of mechanisms of action have been proposed for plant extract to exert their effects. keywords: acetate; diabetic; ethyl; extract; glucose; level; methanol; water cache: bjp-23600.pdf plain text: bjp-23600.txt item: #341 of 942 id: bjp-23604 author: Sabo, Ana; Tomas, Ana; Tomic, Natasa; Mikov, Momir; Horvat, Olga; Popovic, Radmila; Tomic, Zdenko title: Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections date: 2015 words: 4197 flesch: 41 summary: Conclusion Ciprofloxacin in standard dosing regimen remains a good choice of antibiotic for treatment of complicated urinary tract caused by susceptible Gram negative microorganisms, but in severe, recurrent or chronic infections, especially those caused by Gram positive bacteria which often have higher MIC values, deeper analysis is necessary in order to achieve optimal results. AUC/MIC and Cmax/MIC were calculated as the area under the concentration–time curve or the highest concentration reached over 24 hours divided by determined MIC values of tested pathogens. keywords: ciprofloxacin; concentration; dosing; effect; hours; infections; mic; pharmacokinetic; tract cache: bjp-23604.pdf plain text: bjp-23604.txt item: #342 of 942 id: bjp-23610 author: Ashwini, Appaji Mahesh; Puttarudrappa, Latha; Ravi, Belagumba Vijaykumar; Majumdar, Mala title: GC-MS analysis, evaluation of phytochemicals, anti-oxidant, thrombolytic and anti-inflammatory activities of Exacum bicolor date: 2015 words: 5492 flesch: 55 summary: Wong CC, Li HB, Cheng KW, Chen F. A systematic survey of anti-oxidant activity of 30 Chinese medicinal plants using the ferric reducing anti-oxidant power assay. Investigation on in vitro anti-inflammatory activity by human red blood cell membrane stabilization method in E. bicolor exhibited 87.2 ± 2.6% of protection at 100 µg/mL with IC50 value of 37.4 µg/mL, whereas Leelaprakash and Dass (2011) reported 30 ± 0.0% inhibition of hemolysis in Enicostemma axillare methanol extract of which the present study exhibited potent anti-inflammatory activity. keywords: activities; activity; analysis; anti; bicolor; clot; dpph; extract; methanol; phenols; total cache: bjp-23610.pdf plain text: bjp-23610.txt item: #343 of 942 id: bjp-23611 author: Khan, Wasi Ullah; Khan, Rahmat Ali; Ahmed, Mushtaq; Khan, Latif Ullah; Khan, Muhammad Waqas title: Pharmacological evaluation of methanolic extract of Cyperus scariosus date: 2016 words: 3780 flesch: 62 summary: Hydroxyl radical scavenging activity The hydroxyl radical scavenging activity can be categorized as 3 mg/mL > 1.5 mg/mL > 0.75 mg/mL > 0.37 mg/mL. All results showed anti-oxidant activity in dose-dependent manner at concentration 3-0.37 mg/ References Bajpai M, Pande A, Tewari SK, Prakash D. Phenolic contents and anti-oxidant activity of some food and medicinal plants. keywords: activity; anti; extract; khan; scariosus; scavenging cache: bjp-23611.pdf plain text: bjp-23611.txt item: #344 of 942 id: bjp-23637 author: Nayab, Pattan Sirajuddin; Pulaganti, Madhusudana; Chitta, Suresh Kumar; Oves, Mohammad; ., Rahisuddin title: Synthesis, spectroscopic studies of novel N-substituted phthalimides and evaluation of their antibacterial, antioxidant, DNA binding and molecular docking studies date: 2015 words: 7218 flesch: 56 summary: A comparison of antibac- terial activity among all the compounds revealed that compound 3b was found to be very promising against E. coli and S. mutans. The C-4 substitution with a methoxy group in compound 3b increases the electronic density of the aromatic ring, which may increase its anti-microbial activity. keywords: activity; binding; compounds; dna; nmr; ppm; spectra; studies; test cache: bjp-23637.pdf plain text: bjp-23637.txt item: #345 of 942 id: bjp-23642 author: Roy, Anggana; Bashir, Yasir; Rather, Irfan Ahmad; Konwar, Bolin Kumar title: Genome size determination of Eclipta alba and Aloe barbadensis date: 2015 words: 3948 flesch: 66 summary: Reference standards for determination of DNA content of plant nuclei. Plant genome size research: A field in focus. keywords: alba; barbadensis; dna; genome; plant; size cache: bjp-23642.pdf plain text: bjp-23642.txt item: #346 of 942 id: bjp-23644 author: Bhuiyan, Habiba Akhter; Tshering, Kipchu; Misbahuddin, Mir title: Estimation of arsenic in nail using silver diethyldithiocarbamate method date: 2015 words: 2465 flesch: 62 summary: Toenail samples as an indicator of drinking water arsenic exposure. Justification of using toenail is the chance of less contamination with arsenic contaminated water. keywords: acid; arsenic; nails; solution; use; water cache: bjp-23644.pdf plain text: bjp-23644.txt item: #347 of 942 id: bjp-23645 author: Li, Tie-Ling; Guo, Hai-Feng; Li, Fu-Juan; Sun, Zhi-Guo; Zhang, Heng-Chun title: Synthesis and biological evaluation of 6H-1-benzopyrano[4,3-b]quinolin-6-one derivatives as inhibitors of colon cancer cell growth date: 2015 words: 5912 flesch: 57 summary: Among the eight compounds studied, 3C, with a difluoro substitution on the 9 and 10 position of the 6H-1-benzopyrano [4,3-b]quinolin-6-one ring, show- ed selective and potent growth inhibition against colon cancer cells. Overall, these results established that the 9,10- difluoro substitution is significant to the anticancer activity of 6H-1-benzopyrano [4,3-b]quinolin-6-one and that compound 3c was a promising candidate for further studies with colon cancer cells. keywords: b]quinolin-6; cancer; cancer cells; cells; colon; dna; hct-116; hours; mhz; nmr cache: bjp-23645.pdf plain text: bjp-23645.txt item: #348 of 942 id: bjp-23648 author: Luan, Bing-Guo; Sun, Cai-Xia title: Effect of glabridinon on insulin resistance, C-reactive protein and endothelial function in young women with polycystic ovary syndrome date: 2015 words: 3222 flesch: 52 summary: In adolescent girls, insulin resistance with hyperandrogenism suggests the role of hyperinsu- linemia in polycystic ovary syndrome (Apter et al., 1995). In women with polycystic ovary syndrome a high level of hsCRP is present and there is a correlation between insulin resistance and elevated CRP levels (Tarkun et al., 2004). keywords: glabridin; insulin; ovary; patients; syndrome; treatment; women cache: bjp-23648.pdf plain text: bjp-23648.txt item: #349 of 942 id: bjp-23651 author: Yang, Li-Guang; Tian, Xiang-An; Li, Xiao-Yan; Huang, Jian-Guo; Liu, Nai-Qing; Sun, Qin-Li title: Trolox induces inhibition of cell proliferation and apoptosis in human colon cancer cells date: 2015 words: 3341 flesch: 57 summary: Invasion of cancer cells leads to tissue remodeling like proteolytic degradation of the extracellular matrix (ECM) along with the basement membrane of normal adjacent tissues (Johnsen et al., 1998). Trolox (6-hydroxy-2,5,7,8-tetramethyl- chroman-2-carboxylic acid), an analog of vitamin E has been widely investigated for its role in the inhibition of oxidative stress or damage in cancer cells (Lúcio et al., 2009; Barclay et al., 1995; Forrest et al., 1994). keywords: apoptosis; cancer; cells; colon; hct-15; hours; lines; proliferation; treatment; trolox cache: bjp-23651.pdf plain text: bjp-23651.txt item: #350 of 942 id: bjp-23699 author: Guo, Jin-Jin; Li, Ying-Jie; Xin, Lu-Lu title: Tangeretin prevents prostate cancer cell proliferation and induces apoptosis via activation of Notch signalling and regulating the androgen receptor (AR) pathway and the phosphoinositide 3-kinase (PI3k)/Akt/mTOR pathways date: 2015 words: 6716 flesch: 57 summary: Determination of cell viability The viability of prostate cancer cells were assessed as described previously (Pan et al., 2010; Zheng et al., 2010). Viability of prostate cancer cells was measured at 570 nm using ELISA reader (RT6000, China). keywords: akt; androgen; androgen receptor; apoptosis; cancer; cancer cells; cells; dna; et al; expression; human; inhibition; mtor; notch; pathway; pi3k; prostate; prostate cancer; pten; receptor; regulation; signalling; tangeretin cache: bjp-23699.pdf plain text: bjp-23699.txt item: #351 of 942 id: bjp-23708 author: Zhang, Jing-Wei; Wen, Gong-Ling; Zhang, Lei; Duan, Dong-Mei; Ren, Zhong-Hai title: Sulphureuine B, a drimane type sesquiterpenoid isolated from Laetiporus sulphureus induces apoptosis in glioma cells date: 2015 words: 5590 flesch: 53 summary: Abstract A drimane type sesquiterpenoids, sulphureuine B was isolated from the edible mushroom Laetiporus sulphureus and its antiproliferative properties were investigated using U-87MG glioma cells. The structure of sulphureuine B was identified by the physicochemical methods and spectral data with 98% purity. keywords: apoptosis; cells; chop; control; figure; glioma; hours; mg cells; results; reticulum; stress; sulphureuine; sulphureus; treatment; u-87 cache: bjp-23708.pdf plain text: bjp-23708.txt item: #352 of 942 id: bjp-23709 author: Song, Xin; Liu, Chang-Chun; Hong, Yu-Rong; Zhu, Xiao-Cong title: Anticancer activity of novel oleanolic acid methyl ester derivative in HeLa cervical cancer cells is mediated through apoptosis induction and reactive oxygen species production date: 2015 words: 3265 flesch: 50 summary: Anti-cancer activity of novel oleanolic acid methyl ester derivative in HeLa cervical cancer cells is mediated through apoptosis induction and reactive oxygen species production Xin Song1, Chang-Chun Liu2, Yu-Rong Hong3 and Xiao-Cong Zhu4 Department of 1Special Medical Treatment, 2Neurology, and 3Renal Medicine, Coal General Hospital, Beijing 100 028, China; 4Department of Uropoiesis Surgical, Jishuitan Hospital, Beijing 100 850, China. Annexin V-FITC assay for apoptosis quantification Apoptosis induced by oleanolic acid methyl ester in HeLa cervical cancer cells was evaluated using an annexin V-FITC apoptosis detection kit. keywords: acid; apoptosis; cancer; cells; ester; hela; hours; methyl; oleanolic; vanillate cache: bjp-23709.pdf plain text: bjp-23709.txt item: #353 of 942 id: bjp-23714 author: Ali, Muhammad Zeeshan; Janbaz, Khalid Hussain; Mehmood, Malik Hassan; Gilani, Anwar Hassan title: Antidiarrheal and antispasmodic activities of Polygonum bistorta rhizomes are mediated predominantly through K+ channels activation date: 2015 words: 4042 flesch: 56 summary: Under similar experimental conditions, guinea-pig ileum behaved as quiescent smooth muscle preparation and is considered more useful for the assessment of spasmogenic activity (Mehmood et al., 2011), while rabbit jejunum exhibits spontaneous rhythmic contractions, allowing testing the relaxant (spasmolytic) activity directly without the use of an agonist (Gilani et al., 2008; Khan et al., 2011; Rehman et al., 2013). It has been observed that most of the medicinal plant and plant-derived test compounds exhibit inhibitory effect through K+ channel activation (Gilani et al., 2008; keywords: bistorta; castor; diarrhea; effect; extract; gilani; oil; pharmacol cache: bjp-23714.pdf plain text: bjp-23714.txt item: #354 of 942 id: bjp-23718 author: Sufian, Md. Abu; Haque, Mohammad Rashedul title: Cytotoxic, thrombolytic, membrane stabilizing and anti-oxidant activities of Hygrophila schulli date: 2015 words: 2954 flesch: 53 summary: On the other hand, in anti-oxidant activity test, chloroform soluble fraction revealed mild antioxidant activity (IC50 = 195.1 µg/mL) as compared to standard tert-butyl-1-hydroxytoluene (IC50 = 27.5 µg/ mL). Brand-Williams W, Cuvelier ME, Berset C. Use of free radical method to evaluate anti-oxidant activity. keywords: activity; anti; bangladesh; extract; membrane; schulli cache: bjp-23718.pdf plain text: bjp-23718.txt item: #355 of 942 id: bjp-23732 author: Aslam, Muhammad; Sultana, Nuzhat title: Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters date: 2015 words: 4552 flesch: 58 summary: Stress + V. vinifera juice (8 mL/kg) 134.0 ± 14.6e 121.3 ± 13.0f 109.6 ± 13.0f 101.5 ± 13.9f Stress + Fluoxetine (20 mg/kg) 136.3 ± 13.4e 90.7 ± 12.9f 80.6 ± 14.1f 78.6 ± 13.3f Number of animals = 10; The values are mean ± S.E.M.; ap<0.05; bp<0.01; cp<0.001 when compared with saline-treated unstressed mice; dp<0.05; ep<0.01; fp<0.001 when compared with saline-treated stressed mice (One-way ANOVA followed by Newman-Keuls Post hoc test) Table II Effect of Vitis vinifera juice on immobility time of mice in tail suspension test Treatment Immobility time on day 7 Immobility time on day 15 Immobility time on day 30 Immobility time on day 60 Saline (8 mL/kg) 223.4 ± 7.0 223.8 ± 6.7 225.9 ± 6.0 222.6 ± 7.5 Stress + Saline (8 mL/kg) 255.0 ± 10.9a 253.8 ± 12.1a 255.8 ± 11.8a 248.7 ± 12.0a V. vinifera juice (4 mL/kg) 203.3 ± 7.8b 202.2 ± 12.1b 194.9 ± 10.6c 183.0 ± 5.6c V. vinifera juice (8 mL/kg) 195.2 ± 8.9c 180.0 ± 8.5c 171.8 ± 6.4c 168.1 ± 7.2c Fluoxetine (20 mg/kg) 162.0 ± 10.0c 155.7 ± 10.4c 150.6 ± 10.7c 143.0 ± 10.2c Stress + V. vinifera juice (4 mL/kg) 232.6 ± 14.7 229.2 ± 9.4 220.9 ± 11.6e 205.0 ± 7.6f Stress + V. vinifera juice (8 mL/kg) 219.8 ± 13.0d 201.1 ± 17.3e 190.3 ± 14.4f 188.1 ± 14.7f The current study demonstrated that V. vinifera juice (4 mL/kg and 8 mL/kg, p.o) possesses antidepressant-like activity in unstressed and immobilization-induced stressed mice. keywords: activity; antidepressant; immobility; juice; mice; saline; test; vinifera cache: bjp-23732.pdf plain text: bjp-23732.txt item: #356 of 942 id: bjp-23772 author: Peng, Shang-Jin; Chen, Jue-Wei title: Inhibition of cell proliferation in gastric cancer cell lines on exposure to rubriflordilactone A date: 2015 words: 2861 flesch: 56 summary: Gastric cancer cells are usually present in an environ- ment with acidic pH (Stubbs et al., 1999; Stubbs et al., 1994). Higher rate of proliferation in gastric cancer cells accompanied by faster rates of glycolysis results production of molecules acidic in nature (Holm et al., 1995; Vaupel et al., 1989). keywords: apoptosis; cancer; cell; erk; inhibition; lines; rubriflordilactone; viability cache: bjp-23772.pdf plain text: bjp-23772.txt item: #357 of 942 id: bjp-23779 author: Alamgeer, .; Hasan, Umme Habiba; Uttra, Ambreen Malik; Rasool, Shahid title: Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys date: 2015 words: 9718 flesch: 58 summary: Standard aspirin (100 mg/kg) 5.9 ± 0.0a (18.2%) 7.2 ± 0.0a (55.1%) 6.3 ± 0.0a (69.1%) 5.8 ± 0.0a (75.4%) Aqueous methanol extract (200 mg/kg) 5.5 ± 0.0a (23.6%) 6.7 ± 0.0a (58.5%) 5.7 ± 0.0a (72.1%) 4.6 ± 0.0a (80.6%) n-Butanol fraction (200 mg/kg) 5.6 ± 0.0a (21.8%) 7.1 ± 0.0a (55.9%) 6.3 ± 0.0a (69.0%) 5.3 ± 0.0a (77.5%) Aqueous fraction (200 mg/kg) 6.2 ± 0.0a (13.7%) 9.0 ± 0.0a (44.5%) 7.8 ± 0.0a (61.8%) 7.1± 0.0a (70.1%) Values are expressed as mean ± SEM; n=5; Two-way ANOVA followed by Bonferroni post test used and p<0.05 was considered as significant as compared to arthritic control; Where a = p<0.001 Table IV Effect of Berberis calliobotrys on hematological parameters in arthritic rats Hb (g/dL) RBCs 106/µL WBCs 103/µL Platelets 103/µL ESR mm/1st hr RF IU/mL Treatment groups 9.3 ± 0.1 4.9 ± 0.0 9.4 ± 0.2 1225 ± 105.3 20.3 ± 0.8 48.3 ± 2.0 Arthritic control (3 mL/kg) Treatment groups 262.0 ± 3.6 223.6 ± 3.9 218.2 ± 3.5 208.4 ± 4.5 Arthritic control (3 mL/kg; distilled water) keywords: arthritis; butanol; calliobotrys; control; day; extract; fraction; inflammatory; rats cache: bjp-23779.pdf plain text: bjp-23779.txt item: #358 of 942 id: bjp-23788 author: Erum, Alia; Bashir, Sajid; Saghir, Shazia title: Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential date: 2015 words: 2917 flesch: 51 summary: Physicochemical properties of modified arabinoxylans were different from arabinoxylan yet were satisfactory for their use as pharmaceutical excipients. These properties of modified arabinoxylans are different from arabinoxylan (Sajid et al., 2014). keywords: activity; arabinoxylan; carboxymethyl; ovata cache: bjp-23788.pdf plain text: bjp-23788.txt item: #359 of 942 id: bjp-23791 author: Wu, Chuanhong; Bao, Jiaolin; He, Chengwei; Lu, Jinjian; Chen, Xiuping title: Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells date: 2015 words: 5010 flesch: 58 summary: 1991-0088 Abstract In the present study, the effect of cucurbitacin B (a natural product with anti- cancer effect) was studied on PC12 cells. Cucurbitacin B induced G2/M cell cycle arrest, autophagy, but not the apoptosis in PC12 cells. keywords: apoptosis; arrest; assay; autophagy; cells; cucurbitacin; effect; figure; mtt; pc12; treatment cache: bjp-23791.pdf plain text: bjp-23791.txt item: #360 of 942 id: bjp-2381 author: Arifuzzaman, Md.; Kandahary, Rafiya Khan; Islam, Md. Rabiul title: Cytotoxicity study of reaction products between isatin and furan date: 2009 words: 2844 flesch: 68 summary: Bangladesh J Pharmacol 2009; 4: 96-100 97 N H O O Y 7 6 4 2 35 1 1a-1d 1a : X = H, Y = H 1b : X = Cl, Y = H 1c : X = H Y = Br 1d : X = H, Y=C2H5 O N O H N H O O NH(C2H5)2 Y 1 Y 1'2'2 3'3 4' 4 5' 5 6' 6 7' 7 8 9 2a : X = H, Y = H 2b : X = Cl, Y = H 2c : X = H, Y = Br 2d : X = H, Y=C2H5 2a-2d X XX Scheme 1 N O H N H O O Br Br N O H N H O O ClCl 1 1'2'2 3'3 4' 4 5' 5 6' 6 7' 7 8 9 1 1'2'2 3'3 4' 4 5' 5 6' 6 7' 7 8 9 N O H N H O O C2H5 C2H5 1 1'2'2 3'3 4' 4 5' 5 6' 6 7' 7 8 9 N O H N H O O 1 1'2'2 3'3 4' 4 5' 5 6' 6 7' 7 8 9 2c LC50 = 0.0005 LC50 = 0.003 LC50 = 0.003 LC50 = 0.011 2b 2d 2a Scheme 2 Scheme 2 Preparation of Bis-[7,7´] diethyl diisatin [3,3´] furan (2d) Similarly compound 2d was prepared from 7- ethylisatin (0.4 g, 2.1 mmoL) in acetic acid (20 mL) and furan (2 mL) in presence of diethylamine (10 mL). keywords: cytotoxicity; furan cache: bjp-2381.pdf plain text: bjp-2381.txt item: #361 of 942 id: bjp-23813 author: Yao, Jie; Cong, Lin; Zhu, Benli; Wang, Ting title: Effect of dietary approaches to stop hypertension diet plan on pregnancy outcome patients with gestational diabetes mellitus date: 2015 words: 4576 flesch: 57 summary: However, the effect of Dietary Approaches to Stop Hypertension (DASH) diet on several metabolic conditions have been previously studied, there are no studies regarding the effects of DASH diet on insulin resistance, inflammation, oxidative stress, and pregnancy outcomes of pregnancy with gestational diabetes in China (Liao et al., 2014). Therefore, the aim of the research was to study the effect of DASH diet on pregnancy outcomes of patients with gestational diabetes in China. keywords: control; dash; dash diet; diabetes; diet; effect; insulin; patients; pregnancy; weight; women cache: bjp-23813.pdf plain text: bjp-23813.txt item: #362 of 942 id: bjp-23819 author: Bajpai, Vivek K.; Rather, Irfan A.; Majumder, Rajib; Shukla, Shruti; Aeron, Abhinav; Kim, Kangmin; Kang, Sun Chul; Dubey, R. C.; Maheshwari, D. K.; Lim, Jeongheui; Park, Yong-Ha title: Exopolysaccharide and lactic acid bacteria: Perception, functionality and prospects date: 2015 words: 13802 flesch: 35 summary: Introduction Overview of exopolysaccharide Lactic acid bacteria are widely exploited in medicine, and traditional dairy products, as well as in biotechno- logical and industrial fermentation processes as a well- established starter culture (Park, 2001; Savadogo et al., 2004; Park et al., 2008; Kim et al., 2013a; Rather et al., 2013; Park et al., 2014). Lactic acid bacteria have shown a significant importance in health complications with increasing number of health beneficial microflora in the intestinal tract (Park et al., 2010), along with an ability to synthesize functional exopolysaccharides (Ricciardi and Clementi 2000; Seo et al., 2001; Savadogo et al., 2004; Kim et al., 2006; Kim et al., 2007). keywords: ability; acid bacteria; addition; antiviral; applications; bangladesh; biosynthesis; biotechnol; cell; characterization; chemical; dairy; effect; eps; et al; exopolysaccharide; exopolysaccharide production; food; gene; glucose; harutoshi; health; hetero; industrial; kim; lactic; lactobacillus; microbial; molecular; number; park; pharmacol; polysaccharides; potential; production; properties; role; sugar; van; virus cache: bjp-23819.pdf plain text: bjp-23819.txt item: #363 of 942 id: bjp-23829 author: Ghosh, Antara; Banik, Sujan; Islam, Md. Ariful title: In vitro thrombolytic, anthelmintic, anti-oxidant and cytotoxic activity with phytochemical screening of methanolic extract of Xanthium indicum leaves date: 2015 words: 3955 flesch: 53 summary: In thrombolytic assay, a significant clot lysis was observed at four concentrations of plant extract compare to the positive control streptokinase (30,000 IU, 15,000 IU) and negative control normal saline. Concentration of 6.25, 12.5, 25, 50 and 100 mg/mL of gallic acid and concentration of 2 mg/mL of plant extract were also prepared in Bangladesh J Pharmacol 2015; 10: 854-859 855 methanol. keywords: activity; bangladesh; clot; control; extract; indicum; leaves; methanolic; plant cache: bjp-23829.pdf plain text: bjp-23829.txt item: #364 of 942 id: bjp-23833 author: Dai, Xiao-Yu; Yu, Yong-Ming; Kong, Zheng-Fang; Cao, Yi-Sheng; Huang, Dan-Dan; Hu, Xiao-Rong; Huang, Zuo-An; Xie, Yang-Yang; Zhang, Shun title: Tectorigenin inhibits Caco-2 human colon cells via NF-κB pathway suppression date: 2015 words: 4070 flesch: 50 summary: The obtained results indicated that IκB phosphorylation on Ser32 was induced by TNF-α and stimulated the IκB degradation in Caco-2 colon cancer cells. That is, tectorigenin exposure arrested the invasion effect of Caco-2 cancer cells upon TNF-α inducement. keywords: activity; cancer; cells; colon; cxcl10; expression; tectorigenin; tnf cache: bjp-23833.pdf plain text: bjp-23833.txt item: #365 of 942 id: bjp-23834 author: Zhou, Bin; Fu, Qiang; Song, Sha-Sha; Zheng, Hong-Li; Wei, Yu-Zhen title: Inhibitory effect of schizophyllan on rat glioma cells date: 2015 words: 3312 flesch: 55 summary: The highly lethal nature of this tumor partly originates from its invasive characte- ristics, which allow tumor cells to migrate and infiltrate eloquent areas making impossible the achievement of a radical surgery. Bangladesh Journal of Pharmacology Research Article Inhibitory effect of schizophyllan on rat glioma cells BJP Introduction Malignant gliomas account for approximately 50% of all central nervous system tumors (Mahaley et al., 1989; keywords: apoptosis; cells; glioma; group; hours; schizophyllan; treatment; tumor cache: bjp-23834.pdf plain text: bjp-23834.txt item: #366 of 942 id: bjp-23835 author: Gong, Xue-Mei; Hu, Cheng-Jiu; Zhao, Quan-Jing; Shi, Dong-Mei title: Equol induces apoptosis in chemoresistant ovarian cancer cells via external pathway date: 2015 words: 5304 flesch: 56 summary: Overall results suggested that equol induces apoptosis in SKOV-3 cells via a TRAIL and caspase 8-dependent pathway whereas paclitaxel leads to smaller apoptotic events when compared to that of equol. SKOV-3 cells (3 × 106/ 76 Bangladesh J Pharmacol 2016; 11: 75-85 sample) were incubated with drugs for 4, 24, or 48 hours (IC50 concentrations) and after this period of time cells were briefly lysed. keywords: apoptosis; assay; cancer; cells; dna; drugs; equol; figure; hours; level; ptx; results; skov-3; time; trail; treatment cache: bjp-23835.pdf plain text: bjp-23835.txt item: #367 of 942 id: bjp-23850 author: Li, Ke; Lin, Wei; Wu, Li-Jun; Qi, Qiang; Shen, Guo Liang; Liu, Jian Jiang; Chen, Wei Xin; Xu, Jun; Qian, Hangen; Zhao, Xiao Yu title: Effects of intravenous arginine on the healing of human skin graft donor sites: A randomized controlled trial date: 2015 words: 3709 flesch: 58 summary: A randomized controlled trial on skin graft donor sites. Oral arginine supplementation and the effect on skin graft donor sites: A randomized clinical pilot study. keywords: arginine; day; donor; graft; group; healing; plasma; sites; skin; wound cache: bjp-23850.pdf plain text: bjp-23850.txt item: #368 of 942 id: bjp-23860 author: Alluri, Narendranath; Majumdar, Mala title: Evaluation of ?-glucosidase inhibition of Drimia nagarjunae, a medicinal plant from South India date: 2015 words: 739 flesch: 49 summary: Bangladesh J Pharmacol. 2015; 10: 635-36. To the best of our knowledge this is the first report on α-glucosidase inhibitory A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2015; 10: 635-636 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088; DOI: 10.3329/bjp.v10i3.23860 Letter to the Editor Figure 1: α-Glucosidase inhibitory activity of D. nagarjunae activity of D. nagarjunae. keywords: glucosidase; nagarjunae cache: bjp-23860.pdf plain text: bjp-23860.txt item: #369 of 942 id: bjp-23872 author: Wang, Zhao-Yang; Wang, Jun-Yong; Zhang, Jun; Zhang, Kai; Fan, Rui; Niu, Jun-Hao title: 5-Bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one targets prostate cancer cells by down-regulating inflammation-related genes date: 2016 words: 3164 flesch: 56 summary: The results revealed that BHP treatment in PC3 cells caused a significant reduction in the rate of cell proliferation in dose- and time-dependent manner. PC3 cells were grown in DMEM supplemented with 10% FBS and cultured in an incubator with humidified atmosphere of 5% CO2 at 37°C. keywords: bhp; cancer; cells; concentration; expression; pc3; prostate; treatment cache: bjp-23872.pdf plain text: bjp-23872.txt item: #370 of 942 id: bjp-23889 author: Janbaz, Khalid Hussain; Khan, Waseem Ullah; Saqib, Fatima; Khalid, Mamoona title: Pharmacological basis for the medicinal use of Viola odorata in diarrhea, bronchial asthma and hypertension date: 2015 words: 5230 flesch: 56 summary: The V. odorata exhibited Ca2+ channel blocking activity in isolated rabbit tissue preparations (i.e., jejunum, trachea and aorta) which can be attributed to the presence of alkaloids (Khalid et al., 2004; Gilani et al., 2005, ), flavonoids (Revuelta et al., 1997; Di-Carlo, 1993) and tannins (Azhar et al., 1997) among the constituents of V. odorata detected in the preliminary phytochemical screening. Isolated rabbit jejunum preparations exhibit sponta- neous rhythmic contractions and allowed testing of the antispasmodic (relaxant) effect without application of an agonist (Janbaz et al., 2015a; Saqib et al., 2012). keywords: ca2; contractions; effect; et al; extract; odorata; pharmacol; preparations; rabbit; verapamil; viola cache: bjp-23889.pdf plain text: bjp-23889.txt item: #371 of 942 id: bjp-23896 author: Madamwar, Datta; Kaushal, Avani; Patel, Dipak K.; Desai, Swati N.; Upadhyay, Kapil; Devkar, Ranjitsinh title: Cyanobacterial phycoerythrin purified from marine Lyngbya sp. induces apoptosis in lung carcinoma cells date: 2015 words: 5162 flesch: 50 summary: Cyanobacterial cell mass was washed with 1 M Tris Cl buffer (pH 8.1) containing 3 mM sodium azide. At this stage, it was assumed that, cyanobacterial phycoerythrin induced cell death was possibly due to the trigger of apoptotic pathway. keywords: a549; apoptosis; apoptotic; assay; carcinoma; cells; devkar; dose; figure; lung; phycoerythrin; potential; staining cache: bjp-23896.pdf plain text: bjp-23896.txt item: #372 of 942 id: bjp-23898 author: Hussain, Musaddique; Raza, Shahid Masood; Majeed, Abdul title: Folkloric uses of Jatropha gossypifolia in emesis and gut motility disorders: Pharmacological validation date: 2015 words: 4086 flesch: 49 summary: Control Without atropine With atropine 0.003 0.03 0.3 3.0 Extract of J. gossypifolia (mg/mL) % o f m ax im um re sp on se b y ac et yl ch ol in e 150 125 100 75 50 25 0 866 Bangladesh J Pharmacol 2015; 10: 864-869 the presence of atropine (0.1 μM), spasmogenic effect was abolished while the spasmolytic effect was observed with EC50 value of 1.7 mg/mL (95% CI: 0.32- 2.95, n = 3). Adulterants free and electrically grinded coarse powdered material (#40) was subjected to triple maceration (Hussain et al., 2013), with 80% ethanol- aqueous mixtures to produce the ethanolic extract of J. gossypifolia. keywords: ca2; effect; extract; gossypifolia; jejunum; pharmacol cache: bjp-23898.pdf plain text: bjp-23898.txt item: #373 of 942 id: bjp-23906 author: Mirmalek, Seyed Abbas; Parsa, Tina; Parsa, Yekta; Yadollah-Damavandi, Soheila; Salimi-Tabatabaee, Seyed Alireza; Jangholi, Ehsan; Hosseini, Sahar; Ashkani-Esfahani, Soheil; Abooghadareh, Hanieh; Haghighifard, Erfan title: The wound healing effect of Iris forentina on full thickness excisional skin wounds: A histomorphometrical study date: 2015 words: 3314 flesch: 58 summary: Results indicated that I. florentina can be prescribed as a herbal medicine for treatment of skin wounds or be used as an additional agent for today's common medicines. Conclusion Overall, I. florentina, a medicinal herb which is introduced by ancient medicine for various skin problems, specifically skin injuries, and also was evaluated by today's scientific researches, has shown beneficial properties to be prescribed as a natural remedy or an additional treatment for skin wounds. keywords: control; florentina; group; healing; iris; skin; study; vehicle; wound cache: bjp-23906.pdf plain text: bjp-23906.txt item: #374 of 942 id: bjp-23953 author: Zheng, Mengli; Zhou, Naikang; Ma, Lianjun; Jin, Wenbo title: Amrubicin therapy improves patients with refractory small-cell lung cancer: A single-arm confirmatory Chinese clinical study date: 2016 words: 3823 flesch: 51 summary: Matsunaga Y, Hamada A, Okamoto I, Sasaki J, Moriyama E, Kishi H, Matsumoto M, Hira A, Watanabe H, Saito H. Pharmacokinetics of amrubicin and its active metabolite amrubicinol in lung cancer patients. A phase II study of amrubicin and carboplatin for previously untreated patients with extensive- disease small cell lung cancer. keywords: amrubicin; cancer; cell; cell lung; grade; lung; lung cancer; patients; response; study; treatment cache: bjp-23953.pdf plain text: bjp-23953.txt item: #375 of 942 id: bjp-23981 author: Vishwanathan, B.; Gurupadayya, B. M.; Sairam, K. Venkata title: In silico and antithrombotic studies of 1,3,4-oxadiazoles derived from benzimidazole date: 2015 words: 4681 flesch: 51 summary: Compound 4d (4-aminophenyl) exhibited the highest thrombolytic activity among the series with mean clot lysis value of 43.7% and compound 4a (phenyl) exhibited the least activity with mean clot lysis value of 12.0%. Compound 4j (pyridin-3-yl) exhibited a mean clot lysis value of 49.0% being the highest and 4a (phenyl) being the least with mean clot lysis value of 16.0%. keywords: 4a-4k; clot; compounds; docking; hydrogen; lysis; mean; oxadiazoles; score; value cache: bjp-23981.pdf plain text: bjp-23981.txt item: #376 of 942 id: bjp-23984 author: Khan, Bilal Muhammad; Bakht, Jehan title: Antifungal, anti-yeast, anti-oxidant and HPLC analysis of different solvent extracted samples from Calamus aromaticus leaves date: 2015 words: 6850 flesch: 58 summary: It was followed by hexane extracted sample with 53.3%, 66.5% and 80.2% activity at 500, 1000 and 2000 µg/disc respectively. Anti-oxidant activity The data in Figure 1 suggested that all extracted samples from the leaves showed DPPH radical scavenging potential at each of the seven concentrations used in the present study. keywords: acetate; acid; activity; butanol; ethyl; extract; gallic; leaves; oxidant; plant; samples; solvent cache: bjp-23984.pdf plain text: bjp-23984.txt item: #377 of 942 id: bjp-23991 author: Khan, Farman Ali; Jan, Abdul Khaliq; Khan, Nasir Mehmood; Khan, Nayab Ali; Khan, Shahnaz title: GC/MS analysis, antimicrobial and in vitro anti-cholinesterase activities of the essential oil from Buddleja asiatica date: 2015 words: 3450 flesch: 56 summary: Antibacterial activity B. asiatica essential oil was screened for their antibac- terial assay against selected bacterial strains including; Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6663), Staphylococcus aureus (ATCC 25923), Shigella boydii (ATCC 35966), Shigella flexneri (ATCC 14028), Pseudomonas aeruginosa (ATCC 27853) and Salmonella typhi (ATCC 19430) according to agar–well diffusion method (Rahman et al., 2011). Briefly, the stock solu- tions of B. asiatica essential oil prepared in dimethyl- sulfoxide. keywords: ache; activities; activity; ali; asiatica; bche; buddleja; oil cache: bjp-23991.pdf plain text: bjp-23991.txt item: #378 of 942 id: bjp-24001 author: Li, Da-Lu; Wei, Zhu-Liang; Zhang, Wen-Mei; Li, Zhi-Gang title: Anti-tumor activity of cabozantinib by FAK down-regulation in human oral squamous cell carcinoma date: 2015 words: 4574 flesch: 59 summary: We studied anti-cancer properties of cabozantinib in oral squamous cell carcinoma cells. The results from this study revealed that cabozantinib can be useful in developing a drug for effective treatment of oral squamous cell carcinoma cells. keywords: apoptosis; bhy; cabozantinib; cancer; cells; concentration; control; dmso; fak; hours; hsc-3; treatment cache: bjp-24001.pdf plain text: bjp-24001.txt item: #379 of 942 id: bjp-24034 author: Banerjee, Amartya; Firdous, S. M. title: Antiulcer activity of hydroalcoholic extract of Ipomoea staphylina plant in rats date: 2015 words: 1232 flesch: 52 summary: In ethanol induced gastric ulcer, the pretreatment with hydroalcoholic extract of I. staphylina plant showed a dose-dependent reduction in the severity of the lesions. 653 Bangladesh J Pharmacol 2015; 10: 652-653 Table II Effect of hydroalcoholic extract of Ipomoea staph- ylina plant against ethanol induced gastric ulcer in rats Groups Treatment Ulcer Index % Protection I Control 74.0 ± 2.4 II Omeprazole (20 mg/kg) 42.0 ± 2.0a 43.2 III Ipomoea staphylina (200 mg/kg) 20.0 ± 3.2a 73.0 IV Ipomoea staphylina (100 mg/kg) 38.0 ± 3.7a 48.6 All values are expressed as mean ± SEM; ap<0.001 when compared with control mailto:firdous.cology@gmail.com DatePrinted: keywords: extract; staphylina cache: bjp-24034.pdf plain text: bjp-24034.txt item: #380 of 942 id: bjp-24055 author: Chander, M. Punnam; Pillai, C. R.; Vijayachari, P. title: Antimalarial efficacy of nine medicinal plants traditionally used by the Karens of Andaman and Nicobar Islands, India date: 2015 words: 2343 flesch: 47 summary: In vitro test for antimalarial activity The in vitro activity of P. falciparum intraerythrocytic stage on crude plant extracts was evaluated by Schizont maturation Inhibition M-III method (WHO, 2001). The antimalarial activity of plant extracts was assessed against chloroquine-sensitive P. falciparum (MRC-2) isolate obtained from the National Institute of Malaria Research (ICMR), New Delhi, India. keywords: activity; andaman; antimalarial; india; islands; nicobar; plants cache: bjp-24055.pdf plain text: bjp-24055.txt item: #381 of 942 id: bjp-24056 author: Kamran, Sairah Hafeez; Ahmad, Mobasher; Shahwar, Durre; Ajaib, Muhammad title: Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts date: 2016 words: 5360 flesch: 57 summary: 229 ± 11.4b 247 ± 7.5c 294 ± 9.4 L. pulverulentus (P. nigra) leaf 301 ± 14.1 308 ± 10.6 273 ± 11.4 261 ± 11.7 250 ± 7.91b 279 ± 6.4 302 ± 8.1 L. pulverulentus (P. nigra) stem 294 ± 13.3 307 ± 12.5 310 ± 7.7 289 ± 7.29 299 ± 6.9 289 ± 7.6 298 ± 9.6 Data is presented as mean ± SEM; n=5; Control diabetic group is compared with all groups, ap<0.001, bp<0.01, cp<0.05 (Dunnett test with 95% confi- dence interval) Table V Effect of various fractions of L. pulverulentus (D. sissoo) leaves and stems on glucose and total anti-oxidant activity in alloxan-treated diabetic mice Sample Glucose (mg/dL) level on day 7 (leaves) Total AOA (mmol/L) on day 7 (leaves) Glucose (mg/dL) level on day 7 (stems) There was no significant decrease in Table III Total phenolic contents, flavonoids and anti-oxidant capacity of various fractions of L. pulverulentus (D. sissoo) and L. pulverulentus (P. nigra) leaves and stems Sample Total phenols gallic acid equivalent mg/g Total anti-oxidant activ- ity equivalent to BHT mg/g extract Total flavonoids mg/g plant extract in querce- tin equivalent HF 196.4 ± 2.2 411.6 ± 3 493.4 ± 1.7 EAF 214.5 ± 3.6 504.9 ± 35.7 336.1 ± 6.5 keywords: anti; fraction; leaves; pulverulentus; sissoo; stems cache: bjp-24056.pdf plain text: bjp-24056.txt item: #382 of 942 id: bjp-24141 author: Keche, Yogendra Narayanrao; Yegnanarayan, Radha; Bhat, Shreepad title: Effect of vitamin B12 supplementation on glycemic control in poorly controlled hyperhomocysteinemic type 2 diabetic patients date: 2015 words: 2578 flesch: 51 summary: There was significant rise in vitamin B12 levels and significant fall in HbA1c levels in vitamin B12 deficient patients with vitamin B12 supplementation at 4 weeks (Table III). At 4 weeks, HbA1c decreased from 9.9 ± 0.9 to 8.7 ± 0.5 (p<0.01) in vitamin B12 deficient patients after vitamin B12 supplementation. keywords: b12; diabetic; patients; type; vitamin; weeks cache: bjp-24141.pdf plain text: bjp-24141.txt item: #383 of 942 id: bjp-24149 author: Peng, Nai-Xiong; Liu, Chun-Xiao; Wang, Xi-Sheng; Zhang, Ze-Jian; Liao, Su-Cai title: Combination of axitinib and dasatinib for anti-cancer activities in two prostate cancer cell lines date: 2015 words: 4541 flesch: 55 summary: Axitinib and dasatinib combination lowered the survival rate of PPC-1 cells but enhanced the survival rate of TSU-Pr1 cells. 48 and 72 hours after administration of 20 mM of the equimolar concentration of axitinib and dasatinib, the viability of PPC-1 cells significantly decreased to 88 and 82% respectively (Figure 1). keywords: apoptosis; axitinib; cancer; cells; dasatinib; expression; figure; ppc-1; pr1; prostate; treatment; tsu cache: bjp-24149.pdf plain text: bjp-24149.txt item: #384 of 942 id: bjp-24151 author: Ponnuswamy, Shekar; Kannaiyan, Sathishkumar; Venugopal, Gopikrishnan; Manikkam, Radhakrishnan title: Antiproliferative activity of yellow pigment from forest soil Streptomyces sp SFA5 against breast cancer cell line MCF-7 date: 2015 words: 661 flesch: 40 summary: Bangladesh Journal of Pharmacology Volume: 10; Number 3; Year 2015 Cite this article as: Ponnuswamy S, Kannaiyan S, Venugopal G, Manikkam R. Antiproliferative activity of yellow pigment from forest soil Streptomyces sp SFA5 against breast cancer cell line MCF-7. Antiproliferative activity of crude pigment against breast cancer cell line MCF-7 was determined by MTT assay described by Carmichael et al., (1987). keywords: cancer; cell; pigment cache: bjp-24151.pdf plain text: bjp-24151.txt item: #385 of 942 id: bjp-24153 author: Rasool, Shahid; Khan, Farrukh Zia; Ahmad, Mobasher title: Evaluation of anticonvulsant, antimicrobial and hemolytic activity of Aitchisonia rosea date: 2015 words: 5065 flesch: 58 summary: After administration of plant extract and fractions, following parameters were observed: a) latency (onset of clonus), b) duration of tonic convulsions, c) status of animal after 30 min, d) status of animal after 24 hours and e) percentage protection Antimicrobial activity The antimicrobial assay for plant extract and fractions against different bacterial and fungal strains was conducted by disc diffusion method and minimum inhibitory concentration (MIC) (Ergene et al., 2006). A solution of plant extract and each fraction was prepared at a concentration of 1 mg/mL in dimethyl sulfoxide solution. keywords: acetate; activity; antimicrobial; convulsions; ethyl; extract; fractions; methanol; plant; rosea cache: bjp-24153.pdf plain text: bjp-24153.txt item: #386 of 942 id: bjp-24157 author: George, Elizabeth; Kasipandi, Muniyandi; Vekataramana, Mudili; Kumar, Kalagatur Naveen; Allen, Joseph Anthuvan; Parimelazhagan, Thangaraj; Gopalan, Natarajan title: In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth date: 2016 words: 6225 flesch: 56 summary: Bacterial cells and fungal spores and hyphae showed visible damages due to the treatment of ethyl acetate extract. This bacterial culture was treated with ethyl acetate extract of P. mollis (20 µg). keywords: acetate; acetone; acid; activity; anti; assay; cells; damage; dna; ethyl; extract; methanol; mollis; oxidant; scavenging cache: bjp-24157.pdf plain text: bjp-24157.txt item: #387 of 942 id: bjp-24163 author: Shukla, Shruti; Majumder, Rajib; Ahirwal, Laxmi; Mehta, Archana title: Proposed mechanism of antibacterial mode of action of Caesalpinia bonducella seed oil against food-borne pathogens date: 2016 words: 4360 flesch: 45 summary: Previously we reported the antibacterial, antidia-betic, antioxidant, anti-inflammatory, anti-pyretic and analgesic properties of C. bonducella seed oil (Shukla et al., 2010). Measurement of extracellular adenosine 5’-triphophate (ATP) concentration To determine the efficacy of C. bonducella seed oil on membrane integrity, the extracellular ATP concentra- tions were measured according to the previously described method (Bajpai et al., 2013). keywords: bonducella; bonducella seed; coli; food; membrane; monocytogenes; oil; seed; seed oil cache: bjp-24163.pdf plain text: bjp-24163.txt item: #388 of 942 id: bjp-24165 author: Hao, Ji-Heng; Hu, Dian-Feng; Mao, Li-Mei; Zhang, Shi-Gang; Wang, Ji-Yue; Li, Gang title: Inhibition of cell proliferation by 2-fluorobenzaldehyde retinoic acid conjugate through suppression of STAT3 activation in human glioma cells date: 2015 words: 3036 flesch: 50 summary: Determination of apoptosis in U373 cells Analysis of apoptosis in U373 glioma cells was performed by using annexin V-FITC apoptosis detection kit (MBL) and propidium iodide stain. Cell proliferation assay U373 glioma cells at a density of 3 x 105 cells per well were distributed onto 96-well plates and cultured overnight. keywords: acid; cells; conjugate; expression; fluorobenzaldehyde; glioma; hours; retinoic; stat3; treatment; u373 cache: bjp-24165.pdf plain text: bjp-24165.txt item: #389 of 942 id: bjp-24198 author: Wang, Yang; Zhu, Zheng Fei; Pan, Wei Jun; Xu, Zhe title: Efficacy and safety of goserelin combined with adjuvant chemotherapy in premenopausal women with breast cancer date: 2015 words: 5130 flesch: 54 summary: The average number of cases in experimental group is 54.3, while the average number of cases in control group is 573.8; the research objects in both groups are premenopausal breast cancer patients. The result showed that goserelin combined with chemotherapy group can improve the survival rate and decrease the incidence of arthralgia in postmenopausal breast cancer patients, respectively, compared to the control group. keywords: breast; breast cancer; cancer; chemotherapy; control; goserelin; group; patients; premenopausal; total; women; years cache: bjp-24198.pdf plain text: bjp-24198.txt item: #390 of 942 id: bjp-24238 author: Manikkam, Radhakrishnan; Ponnuswamy, Shekar; Joseph, Jerrine; Kumar, Vanaja title: Antitubercular activity of the pigment from forest soil Streptomyces sp SFA5 date: 2015 words: 2329 flesch: 50 summary: In enzyme inhibition assay, the MTB-LAT enzyme was inhibited by 4.98 µg/ mL concentration of crude pigment. In the present study, crude pigment exhibited good antitubercular activity in both rapid and whole-cell screening based methods such as microplate alamar blue assay and luciferase reporter phage assay. keywords: activity; assay; pigment; sfa5; streptomyces; tuberculosis cache: bjp-24238.pdf plain text: bjp-24238.txt item: #391 of 942 id: bjp-24251 author: Khan, Imran Ahmad; Janbaz, Khalid Hussain; Saqib, Fatima title: Antidiarrheal activity of methanolic leaf extract of Rumex vesicarius date: 2016 words: 3961 flesch: 57 summary: I Castor oil (1 mL p.o) + saline (2 mL/kg i.p) 2.4 ± 0.1 --- II Castor oil (1 mL p.o) + atropine (3 mg/kg i.p) 1.8 ± 0.1b 24.4 III Castor oil (1 mL p.o) + R. vesicarius (200 mg/kg i.p) 1.7 ± 0.1a 26.1 IV Castor oil (1 mL p.o) + R. vesicarius (400 mg/kg i.p) 1.2 ± 0.1b 49.3 Effect of R. vesicarius on castor oil-induced enteropooling in rats: R. vesicarius was administered i.p 1 hour before castor oil administration. R. vesicarius has been in use cooling agent, astringent, anti-venom agent and appetizer for the treatment of allaying pain of toothache, nausea, and insect bite, seeds were used for dysentery (Dymoke, 1972). keywords: castor; castor oil; diarrhea; i.p; oil; vesicarius cache: bjp-24251.pdf plain text: bjp-24251.txt item: #392 of 942 id: bjp-24334 author: Li, Jun; Xu, Ze-Qing; Bao, Ling; Li, Zhi-Cao; Qu, Jia-Xiang title: Protective effects of paeonol on cardiovascular complications in diabetes mellitus involves modulation of PI3K /Akt-GSK-3β signalling, regulation of protease-activated receptor-1 expressions and down-regulation of inflammatory mediators date: 2015 words: 7452 flesch: 46 summary: It possess bioactive properties as anti-inflammatory (Du et al., 2010; Siu, 2010; Himaya et al., 2012; Lin et al., 2015), neuroprotective (Hsieh et al., 2006; Wu et al., 2008; Su et al., 2010) and cardioprotective effects (Li et al., 2012). Further, oxidative stress is associated with inflammation (Zhang et al., 2010). keywords: 0.1a; akt; cardiomyopathy; cell; collagen; control; diabetes; diabetic; effects; et al; glycogen; gsk-3β; levels; paeonol; pharmacol; rats; streptozotocin; treatment; weeks cache: bjp-24334.pdf plain text: bjp-24334.txt item: #393 of 942 id: bjp-24338 author: Ma, Xu-Chen; Dong, Shuo; Zhang, Shao-Yan; Jia, Ning; Ou, Song-Lei title: Taraxerone triterpene inhibits cancer cell growth by inducing apoptosis in non-small cell lung cancer cells date: 2016 words: 3119 flesch: 54 summary: Abstract The objective of the present study was to evaluate the anti-cancer effects of taraxerone in non-small cell lung cancer cells (A-549). Taraxerone triterpene inhibits cancer cell growth by inducing apoptosis in non-small cell lung cancer cells Xu-Chen Ma, Shuo Dong, Shao-Yan Zhang, Ning Jia and Song-Lei Ou Department of Thoracic Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100 029, China. keywords: a-549; apoptosis; cancer; cell; effects; figure; growth; hours; lung; taraxerone cache: bjp-24338.pdf plain text: bjp-24338.txt item: #394 of 942 id: bjp-24339 author: Zhong, Xiao-Jun; Jia, Hui; Hu, Ji-Long; Le, Fei; Zhong, Xiao-Ming title: Acetoxyroyleanone exhibits selective anti-cancer effects and induces apoptosis in human colon carcinoma cells through the mediation of NF-kappaB and caspase-3 signalling pathways date: 2016 words: 3509 flesch: 38 summary: It has been reported that abietane diterpenes are often reported to exhibit cyto- toxic effects on cancer cell lines. In vitro cytotoxic effect of acetoxyroyleanone against different human cancer cell lines In this study, in vitro inhibitory effect of acetoxyroyleanone was evaluated using the MTT viability assay against a range of cancer cell lines and IC50 after 48 hours was calculated. keywords: acetoxyroyleanone; apoptosis; cancer; caspase-3; cell; colo-205; concentration; lines; migration cache: bjp-24339.pdf plain text: bjp-24339.txt item: #395 of 942 id: bjp-24390 author: Yang, Long; Dong, Xiu-Juan title: Potential role of P2X7 receptor in regulating kidney stem cells in the course of acute kidney injury date: 2016 words: 2893 flesch: 53 summary: The patient with acute kidney injury faces 30- 40% mortality (Lameire et al., 2006) Even after a lot of research there is no specific improvement in this field with suitable therapy to treat acute kidney injury other than some develop- ment in supportive care (Murugan and Kellum, 2011). keywords: acute; day; expression; figure; injury; kidney; mice; p2x7r; tissue cache: bjp-24390.pdf plain text: bjp-24390.txt item: #396 of 942 id: bjp-24401 author: Nastas?, Cristina; Duma, Mihaela; Tiperciuc, Brindusa; Oniga, Ovidiu title: Antimicrobial screening of new 5-(chromene-3-yl)methylene-2,4-thiazolidinediones date: 2015 words: 1227 flesch: 47 summary: Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1,2,4-triazoles, 1,2,4 -triazines and 1,2,4-triazepines ring systems. Chromone and related compounds are wide-spread in nature and exhibit a wide range of pharmacological activity like antibacterial, antifungal (Hatzade et al., 2010, Ali and Ibrahim, 2010), antitumor, anti-oxidant, anti-HIV, antiulcerant, anti-inflammatory. keywords: activity; atcc; compounds; new cache: bjp-24401.pdf plain text: bjp-24401.txt item: #397 of 942 id: bjp-24405 author: Kibiti, Cromwell Mwiti; Afolayan, Anthony Jide title: Antifungal activity and brine shrimp toxicity assessment of Bulbine abyssinica used in the folk medicine in the Eastern Cape Province, South Africa date: 2016 words: 6274 flesch: 62 summary: Acetone extract Aqueous extract Essential oil Amphotericin B c a b c d e 0.0625 mg/mL 0.125 mg/mL 0.25 mg/mL 0.5 mg/mL 1 mg/mL C Amphotericin B Sea waterEssential oil Aqueous extract Acetone extract Plant fractions and controls 40 35 30 25 20 15 10 5 0 H at ch ab ili ty s uc ce ss (% ) The low hatchability success observed with this plant species could be predicted to the presence of A 100 90 80 70 60 50 40 30 20 10 0 M or ta lit y (% ) Plant fractions and controls Figure 2: Percentage mortality of A. salina nauplii. keywords: acetone; extract; fractions; hours; plant cache: bjp-24405.pdf plain text: bjp-24405.txt item: #398 of 942 id: bjp-24406 author: Rajkumar, Krishnamoorthy; Malathi, Ramaswamy title: Phytochemical investigation, GC-MS analysis and in vitro antimicrobial activity of Coleus forskohlii date: 2015 words: 4172 flesch: 54 summary: Chloroform, Eth- Ethanol, Ace- Acetone 926 Bangladesh J Pharmacol 2015; 10: 924-930 source of phytochemicals as compared to the other extracts, whereas, in case of root ethanol extract was the best source of phytochemicals. GC-MS result clearly indicated the plant of C. forskohlii root ethanol extract have following compounds, n -hexadecanoic acid have antibacterial and antifungal properties (Agoramoorthy et al., 2007), betulin anticancer activities, apoptosis (Patocka, 2003; keywords: activity; compounds; ethanol; extract; forskohlii; plants; root; stem cache: bjp-24406.pdf plain text: bjp-24406.txt item: #399 of 942 id: bjp-24472 author: Tabassum, Nazia; ., Alamgeer; Aziz, Abdul; Ahmad, Bashir title: Evaluation of pharmacological effect of Teucrium stocksianum extract on angiogenesis using chorioallantoic membrane assay date: 2016 words: 4056 flesch: 61 summary: Primary 1.0 0.7 0.6 0.5 0.4 Secondary 0.8 0.6 0.4 0.5 0.5 Tertiary 0.5 0.4 0.3 0.3 0.2 A B C D E 624 Bangladesh J Pharmacol 2015; 10: 621-627 Figure 2: SPIP generated branching pattern and quantification of primary, secondary and tertiary blood vessels 1=Primary blood vessel (PBVs), 2= Secondary blood vessel (SBVs), 3= Tertiary blood vessel (TBVs); A = Control, B = 0.03% treated T. stocksianum, C = 0.05% treated T. stocksianum, D = 0.1%treated T. stocksianum, E =0.5%treated T. stocksianum, a – e = quantifica- tion of blood vessels in term of diameter of above mentioned control, standard and test samples Table II Control and treated CAMs roughness parameters (T. stocksianum) Parameters Control Concentration of extract 0.03% 0.05% 0.1% 0.5% Average roughness 81.1 ± 1 72.3 ± 2.2 ⃰ 67.8 ± 2.0 ⃰ 49.2 ± 2.5 ⃰⃰ 57.0 ± 9.1 ⃰⃰ Root mean square deviation 86.1 ± 3 71.1 ± 4.0 ⃰⃰ 71.5 ± 1.6 ⃰⃰ 56.7 ± 3.0 ⃰⃰ 64.8 ± 10.2 ⃰⃰ Skewness of the surface 1.0 ± 0.0 0.5 ± 0.2 ⃰⃰ 0.9 ± 0.1 0.1 ± 0.0 ⃰⃰ 0.8 ± 0.1 Kurtosis of the surface 2.3 ± 0.0 3.3 ± 0.1 ⃰⃰ 3.1 ± 0.1 ⃰⃰ 3.6 ± 0.1 ⃰⃰ 3.7 ± 0.6 Lowest valley 282.4 ± 2.2 263.9 ± 7.2 ⃰⃰ 261.0 ± 1 ⃰⃰ 231.0 ± 1.6 ⃰⃰ 225.0 ± 10.1 ⃰⃰ Maximum height of the surface 282.4 ± 2.2 263.9 ± 7.2 ⃰⃰ 261.08 ± 1 ⃰⃰ 231.0 ± 1.5 ⃰⃰ 225.04 ± 10.1 ⃰⃰ Arithmetic mean summit 1.9 ± 1.1 1.0 ± 2.6 ⃰⃰ 1.0 ± 6.0 ⃰⃰ 1.1 ± 6.4 ⃰⃰ 1.3 ± 2.0 ⃰⃰ Root mean square slope 0.1 ± 7.6 0.1 ± 1.3 ⃰⃰ 0.1 ± 5.1 ⃰⃰ 9.3 ± 6.4 ⃰⃰ 8.7 ± 6.6 ⃰⃰ Developed surface area ratio 7.0 ± 9.2 5.7 ± 5.6 ⃰⃰ 1. ± 8.5 ⃰⃰ 4.2 ± 5.2 5.5 ± 1 The Sci value of control was 1.9 ± 0.1 and in treated groups of T. stocksianum Sci was1.2 ± 0.1 with 0.03%, 1.2 ± 0.1with 0.05%, 1.1 ± 0.0 with 0.1% and 5.7 ± 5.6 with 0.5%, (Table II). keywords: area; blood; cam; control; groups; stocksianum; surface; vessels cache: bjp-24472.pdf plain text: bjp-24472.txt item: #400 of 942 id: bjp-24475 author: Majumder, Rajib; Rather, Irfan A.; Bajpai, Vivek K.; Park, Yong-Ha title: In vitro antiviral activity of Lactobacillus plantarum using SPF embryonated eggs and hemagglutination assay date: 2015 words: 1277 flesch: 60 summary: Therefore, high yield titer of viral stocks obtained from SPF chicken eggs, has resulted in its extensive use in research laborites especially in drug and vaccine production. Avian influenza viruses replicated in embryonated chicken eggs. keywords: chicken; egg; eggs; influenza; virus cache: bjp-24475.pdf plain text: bjp-24475.txt item: #401 of 942 id: bjp-24513 author: Jafarvand, Elnaz; Farhangi, Mahdieh Abbasalizad; Alipour, Beytollah; Khoshbaten, Manouchehr title: Effects of coenzyme Q10 supplementation on the anthropometric variables, lipid profiles and liver enzymes in patients with non-alcoholic fatty liver disease date: 2015 words: 4481 flesch: 50 summary: Numerous evidences suggest that anti- oxidants such as vitamin E, vitamin C, α-tocopherol and betaine are capable in improving clinical and histo- logical features of non-alcoholic fatty liver disease (Mouzaki and Allard, 2012) . It has been reported that CoQ10 depletion in plasma as a marker of mitochondrial dysfunction is occurred in non-alcoholic fatty liver disease (Yesilova et al., 2005; Wei et al., 2008) . keywords: coenzyme; coq10; disease; et al; fatty; lipid; liver; non; serum; study cache: bjp-24513.pdf plain text: bjp-24513.txt item: #402 of 942 id: bjp-24532 author: Kumawat, Mukesh Kumar; Chetia, Dipak title: Synthesis, antimalarial activity evaluation and molecular docking studies of some novel dispiro-1,2,4,5-tetraoxanes date: 2015 words: 3887 flesch: 52 summary: Antimalarial activity All the synthesized compounds were evaluated for in vitro antimalarial activity against chloroquine resistant strain-RKL-9 of P. falciparum (Pf) using 96 well-micro- titre plates at the Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. The molecules were subsequently screened for in vitro antimalarial activity against chloroquine resistant strain of Plasmodium falciparum (RKL-9). keywords: 1xc; activity; ch2; compounds; cyclohexyl; stretching; tetraoxane cache: bjp-24532.pdf plain text: bjp-24532.txt item: #403 of 942 id: bjp-24550 author: Li, Zhen; Ge, Hong-Zhou; Xie, Yong-Gang; Li, Shi title: Design and synthesis of triazolyl-napthyl derivative of ?-amyrin and its in vitro anti-cancer and apoptotic activities in human nasopharyngeal carcinoma (HK-1) cell line date: 2016 words: 3719 flesch: 57 summary: In literature we could not find reports on the anti-cancer activity of either alpha-amyrin or beta-amyrin or their derivatives against nasopharyngeal cancer cells and as such this report is the first such report on this cell line. First two authors contributed equally Conclusion TNB synthesized by using click chemistry approach, inhibit nasopharyngeal cancer cell (HK-1 cell line) growth by inducing apoptosis, chromatin condensation, DNA fragmentation and sub-G1 cell cycle arrest. keywords: apoptosis; cancer; carcinoma; cells; cycle; derivative; dna; effect; hk-1; hours; tnb cache: bjp-24550.pdf plain text: bjp-24550.txt item: #404 of 942 id: bjp-24575 author: Li, Hong; Chao, Xu; He, Chun-Ling; Wang, Xin-Mei; Liang, Man; Dong, Chang-Hu title: Alloimperatorin and its epoxide derivative exhibit in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration date: 2016 words: 3394 flesch: 46 summary: Conventional chemotherapeutic agents like pacli- taxel and doxorubicin kill cancer cells by facilitating cell apoptosis or necrosis process. Finally the DNA content and cell cycle distri- bution was analyzed by flow cytometry. keywords: alloimperatorin; apoptosis; cancer; cells; compound; cycle; epoxide; leukemia; migration cache: bjp-24575.pdf plain text: bjp-24575.txt item: #405 of 942 id: bjp-24576 author: Li, Liu-Bing; Lin, Subin; Yan, Jun; Wang, Qian-Liang; Fan, Zhi-Ying; Dong, Qi-Rong; Qin, Jian-Zhong; Xie, Zong-Gang title: Poly-phenolic fraction of Chrysophyllum cainito extract induces cell death in osteosarcoma cells date: 2015 words: 4987 flesch: 54 summary: Bangladesh Journal of Pharmacology Research Article Poly-phenolic fraction of Chryso- phyllum cainito extract induces cell death in osteosarcoma cells BJP Introduction One of most common primary bone sarcoma is osteo- sarcoma which is a leading cause of cancer death among adolescents, young adults and elder population. Poly- phenolic fraction of Chrysophyllum cainito extract induces cell death in osteosarcoma cells. keywords: activity; apoptosis; cainito; cancer; cells; concentration; control; et al; extract; gae; min; osteosarcoma cache: bjp-24576.pdf plain text: bjp-24576.txt item: #406 of 942 id: bjp-24578 author: Song, Yong-Bin; Zhou, Shao-Hui; Cui, Hong-Shang; Liu, Hui-Ning; Liu, Li-Jun title: Casticin treatment inhibits squamous cell carcinoma cell proliferation and arrests cell cycle in S phase date: 2016 words: 3205 flesch: 56 summary: The present study was performed to investigate the effect of casticin on the rate of cell viability, migration capacity and induction of apoptosis in TE-1, squamous cell carcinoma cells. Bangladesh Journal of Pharmacology Research Article Casticin treatment inhibits squa-Casticin treatment inhibits squa-Casticin treatment inhibits squa- mous cell carcinoma cell prolifera-mous cell carcinoma cell prolifera-mous cell carcinoma cell prolifera- tion and arrests cell cycle in S phasetion and arrests cell cycle in S phasetion and arrests cell cycle in S phase BJP Introduction Squamous cell carcinoma is one among the two sub- types of esophageal cancer and is frequently detected in Asia (Jemal et al., 2011; keywords: apoptosis; carcinoma; casticin; cell; cycle; hours; te-1; treatment cache: bjp-24578.pdf plain text: bjp-24578.txt item: #407 of 942 id: bjp-24593 author: Kifayatullah, Muhammad; Sengupta, Pinaki title: Effect of Pericampylus glaucus on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats date: 2016 words: 3764 flesch: 51 summary: However, the crude plant extract of P. glaucus at a dose of 800 mg/kg produced significant reduction in total cholesterol, triglyceride, low density lipoprotein, urea, creatinine increased in high density lipoprotein levels in treated diabetic rats compared to untreated diabetic rats which will definitely reduce the complications associated with diabetes. In diabetic rat, the ethanolic extracts at same dosage of 800 mg/kg produced reduction in blood glucose (14.4 ± 0.2; p< 0.05) after 2 hours of the treatment that became significant (p<0.001) after 4 hours when compared to untreated diabetic control group. keywords: blood; diabetic; extract; glaucus; glucose; group; rats; streptozotocin cache: bjp-24593.pdf plain text: bjp-24593.txt item: #408 of 942 id: bjp-24601 author: Zhang, Zhe; Shen, Ying; Wu, Jian; Cai, Lin title: Enhanced antitumor activity of cucurbitacin B combined with cerulenin in osteosarcoma date: 2015 words: 3003 flesch: 51 summary: Synergistic effect of cerulenin and cucurbitacin B on induction of apoptosis in tumor cells Treatment of tumor tissues with cucurbitacin B, ceru- lenin or their combination induced apoptosis in tumor cells (Figure 5). The IC50 values of cerulenin and cucurbitacin B combination in the proportion of 1:1, 1:2 and 2:1 were 3.5, 7.2 and 8.6 μg/mL, respectively. keywords: cells; cerulenin; combination; cucurbitacin; effect; osteosarcoma cache: bjp-24601.pdf plain text: bjp-24601.txt item: #409 of 942 id: bjp-24644 author: Ge, Zhi-Cheng; Qu, Xiang; Yu, He-Fen; Zhang, Hui-Ming; Wang, Zi-Han; Zhang, Zhong-Tao title: Antitumor and apoptotic effects of bergaptol are mediated via mitochondrial death pathway and cell cycle arrest in human breast carcinoma cells date: 2016 words: 3330 flesch: 53 summary: Bergaptol induces cell apoptosis through mitochondrial pathway and caspase activation To examine whether bergaptol induces apoptosis through this mechanism in MCF-7 cells, we evaluated the expression of cytochrome c, the pro-apoptotic protein Bax, the anti-apoptotic protein Bcl-2, cas- pase-3, caspase-9 and PARP by Western blot analysis. We next examined the apoptosis-related morphological effects caused by bergaptol in MCF-7 cancer cells using diamidine phenylindole dihrdrochloride (DAPI) stain- ing involving fluorescence microscopy. keywords: apoptosis; bergaptol; breast; cancer; cells; control; cycle; effects; mcf-7 cache: bjp-24644.pdf plain text: bjp-24644.txt item: #410 of 942 id: bjp-24659 author: Pablo-Pérez, Saudy Saret; Estévez-Carmona, María Mirian; Meléndez-Camargo, María Estela title: Diuretic activity of the bark of Eysenhardtia polystachya date: 2016 words: 3601 flesch: 53 summary: Antiurolithiatic activity of Eysenhardtia polystachya aqueous extract on rats. I Effect of E. polystachya aqueous extract on urinary excretion and clearances of sodium and potassium Treatment group Urinary excretion of potassium (mEq/min) Sodium clearance (μL/min) Potassium clearance (μL/min) Control (vehicle) 0.6 ± 0.1 5.2 ± 1.0 138.3 ± 22.3 Furosemide (4 mg/kg) 1.6 ± 0.4a 14.8 ± 2.5a 396.9 ± 67.8a Extract (125 mg/kg) 0.8 ± 0.1b 6.9 ± 0.8b 212.2 ± 37.7b Extract (250 mg/kg) 0.8 ± 0.1b 8.4 ± 1.3b 191.9 ± 27.3b Extract (500 mg/kg) 0.9 ± 0.2 8.6 ± 1.8a 252.1 ± 46.2 Extract (750 mg/kg) 0.9 ± 0.2 10.2 ± 2.2a 259.1 ± 56.2 Data are mean ± SEM of six animals in all groups. keywords: diuretic; extract; furosemide; group; polystachya cache: bjp-24659.pdf plain text: bjp-24659.txt item: #411 of 942 id: bjp-24666 author: Poonkodi, Kathirvel; Ravi, Subban title: Phytochemical investigation and in vitro antimicrobial activity of Richardia scabra date: 2016 words: 2901 flesch: 54 summary: 1 mL of R. scabra extract was added to 1st tube and mixed well, from this tube 1 mL of solution was transferred to remaining tubes up to 6th tube. So far, there is no report on isolation and biological activities of R. scabra plant for comparison. keywords: activity; extract; inhibition; methanol; plant; scabra cache: bjp-24666.pdf plain text: bjp-24666.txt item: #412 of 942 id: bjp-24667 author: Janbaz, Khalid Hussain; Akram, Saba; Saqib, Fatima; Khalid, Mamoona title: Antispasmodic activity of Symplocos paniculata is mediated through opening of ATP-dependent K+ channel date: 2016 words: 3600 flesch: 52 summary: Glibenclamide Figure: 2 Effect of S. paniculata (A) and cromakalim (B) on low K+ (20 mM)-, high K+ (80 mM)- and low K+ plus glibenclamide- induced contractions in isolated rabbit jejunum preparations. The relaxant behavior of cromakalim on low K+ (20 mM)-induced contractions of isolated rabbit jejunum preparations was found to be comparable with S. paniculata as activity of both of these relaxant was found to be mitigated following exposure to glibenclamide. keywords: animals; castor; contractions; jejunum; oil; paniculata; rabbit cache: bjp-24667.pdf plain text: bjp-24667.txt item: #413 of 942 id: bjp-24792 author: Zheng, Yi; Wang, Yu; Shang, Yuan-Hong title: Antibacterial activity of seneciolactone isolated from Senecio scandens against some common gastrointestinal tract disease causing bacterial pathogens date: 2016 words: 3206 flesch: 47 summary: Bacterial strains were grown on nutrient agar plates at 37°C and maintained on nutrient agar slants. Anti- bacterial activity of seneciolactone iso- lated from Senecio scandens against some common gastrointestinal tract disease causing bacterial pathogens. keywords: activity; dysenteriae; effect; mbc; scandens; seneciolactone; strains cache: bjp-24792.pdf plain text: bjp-24792.txt item: #414 of 942 id: bjp-24855 author: Kurian, Gino A. title: Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats date: 2016 words: 5144 flesch: 51 summary: The results were com- pared with diabetic control rats (group 2) and normal control (group 1), where no STZ was administered. The results were compared with diabetic control rats (group 2) and normal control (group 1), where no streptozotocin was administered. keywords: blood; cholesterol; control; diabetes; diabetes control; diabetic; effect; g-400; g400; glibenclamide; group; insulin; rats; streptozotocin cache: bjp-24855.pdf plain text: bjp-24855.txt item: #415 of 942 id: bjp-2488 author: Bhowmik, Amrita; Khan, Liakot Ali; Akhter, Masfida; Rokeya, Begum title: Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats date: 2009 words: 4068 flesch: 57 summary: The purpose of this work was to evaluate the hypo- and antihyperglycemic effects of M. indica in normal and both type of diabetic model rats and to find out their possible mode(s) of antidiabetic action. Hypoglycemic activity that is found when given with a simultaneous glucose load in diabetic rats indicates that the extracts may interfere with the intestinal glucose absorption in the gut by various mechanisms (Nahar et al., 2000; Vinik and Wing, 1990; Lempcke, 1987). keywords: diabetic; glucose; indica; min; model; rats; type cache: bjp-2488.pdf plain text: bjp-2488.txt item: #416 of 942 id: bjp-24882 author: Li, Tao; Shi, Hong-Yan; Hua, Yong-Xin; Gao, Chen; Xia, Qing; Yang, Guang; Li, Bin title: Hydroxychloroquine induces inhibition of collagen type II and oligomeric matrix protein COMP expression in chondrocytes date: 2016 words: 3351 flesch: 52 summary: The results revealed no significant change in the rate of cartilage cell proliferation in hydroxychloroquine-treated compared to untreated cells. The rate of growth in cartilage cells was analyzed using MTT assay whereas the Col-2 and COMP expression levels were detected by RT-PCR and Western blotting analyses. keywords: cartilage; cells; chondrocytes; collagen; comp; effect; expression; hours; hydroxychloroquine; type cache: bjp-24882.pdf plain text: bjp-24882.txt item: #417 of 942 id: bjp-24915 author: Liu, Yu; Peng, Tian-Shu; Hu, Xiang-Dang; Li, Shuai-Jun; He, Yong-Heng; Hu, Fan; Jiang, Jinbo title: Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration date: 2016 words: 3609 flesch: 53 summary: Results Anti-tumor activity against Caco-2 colon cancer cells MTT assay revealed that oxypeucedanin hydrate mono- acetate showed a potent growth inhibitory effect on the proliferation of Caco-2 cancer cells with IC50 values 36.4, 42.1 and 46.3 µM at 72, 48 and 24 hours time intervals respectively. It follows therefore, agents which can manage these above mentioned defects could as potential chemotherapeutic agents in controlling the growth of colon cancer cells. keywords: apoptosis; assay; caco-2; cancer; cells; colon; compound; hours; hydrate; migration; monoacetate; oxypeucedanin cache: bjp-24915.pdf plain text: bjp-24915.txt item: #418 of 942 id: bjp-24918 author: Sun, Jing; Wu, Jing; Zhang, Li; Wan, Qi-Yue; Wang, Li-Ci; Liu, Yao-Yang; Wang, Rong-Mei; Sun, De-Qing title: Plumericin inhibits the viability of cervical cancer cells by induction of apoptosis through degradation of DNA structure date: 2016 words: 2708 flesch: 56 summary: Bangladesh Journal of Pharmacology Research Article Plumericin inhibits the viability of Plumericin inhibits the viability of Plumericin inhibits the viability of cervical cancer cells by induction of cervical cancer cells by induction of cervical cancer cells by induction of apoptosis through degradation of apoptosis through degradation of apoptosis through degradation of DNA structure DNA structure DNA structure BJP Introduction Cervical cancer rate has shown increasing trend in the women of young age and comprises the second frequ- ently detected cancer in females throughout the globe (Phongsavan et al., 2010; Wang et al., 2010). Plumericin inhibits the viability of cervical cancer cells by induction of apoptosis through degradation of DNA structure. keywords: apoptosis; bu25tk; cancer; cells; dna; hela; plumericin; treatment; viability cache: bjp-24918.pdf plain text: bjp-24918.txt item: #419 of 942 id: bjp-24932 author: Dalu, Damayanthi; Dhulipala, Satyavati title: Evaluation of possible mechanisms of three plants for blood glucose control in diabetes date: 2016 words: 4388 flesch: 52 summary: Cheng et al., 2006; Kim et al., 2007; Lee et al., 2006; Zhou et al., 2007; Table III Effect of C. orbiculatus, L. indica and V. maderaspatana on glucose uptake in isolated rat hemidiaphragm (mg/g/30 min) Group Treatment (mg/kg) Glucose uptake in normal rats Glucose uptake in diabetic rats I Normal 5.4 ± 0.15 4.7 ± 0.2 II Insulin (0.4 IU) 12.7 ± 0.6b (57.5%) 11.5 ± 0.8b\ (59.2%) III Metformin (0.1%) 9.6 ± 0.2b (43.5%) 8.3 ± 0.9b (43.6%) IV C. orbiculatus (300) 8.4 ± 0.3b (35.7%) 7.5 ± 0.4b (37.7%) V L. indica (400) 9.1 ± 0.5b (40.7%) 7.9 ± 0.2b (40.8%) Therefore, the present investigation was aimed to ascertain in vivo anti-diabetic activity by methods such as glucose uptake activity using isolated rat diaphragm and glycogen synthesis in liver, skeletal muscle and cardiac muscle and in vitro anti-diabetic activity by inhibiting -glucosidase enzyme. keywords: content; diabetic; glucose; glycogen; group; maderaspatana; muscle; orbiculatus; uptake cache: bjp-24932.pdf plain text: bjp-24932.txt item: #420 of 942 id: bjp-24933 author: Perumal, Palanisamy Chella; Sowmya, Sundaram; Velmurugan, Devadasan; Sivaraman, Thirunavukkarasu; Gopalakrishnan, Velliyur Kanniappan title: Assessment of dual inhibitory activity of epifriedelanol isolated from Cayratia trifolia against ovarian cancer date: 2016 words: 3765 flesch: 56 summary: However, compounds depicting anti-ovarian cancer activities from this plant source have not yet been identified and structurally characterized till date. It has been reported to contain huge amount of bioactive compounds such as A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2016; 11: 545-551 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index; ISSN: keywords: cancer; carboplatin; compound; cyclohexane; docking; epifriedelanol; extract; glide; ring; structure; trifolia cache: bjp-24933.pdf plain text: bjp-24933.txt item: #421 of 942 id: bjp-24941 author: Mundugaru, Ravi; Udaykumar, Padmaja; Senthilkumar, Sivanesan; Bhat, Sudhakara title: Cardioprotective activity of fruit of Garcinia pedunculata on isoprenaline-induced myocardial infarction in rat date: 2016 words: 2825 flesch: 50 summary: Bangladesh Journal of Pharmacology Research Article Cardioprotective activity of fruit Cardioprotective activity of fruit Cardioprotective activity of fruit of of of Garcinia pedunculata Garcinia pedunculata Garcinia pedunculata on iso-on iso-on iso- prenalineprenalineprenaline---induced myocardial induced myocardial induced myocardial infarction in ratinfarction in ratinfarction in rat BJP Introduction Myocardial infarction is the acute ischemic condition where profound necrosis of myocardial tissue occurs. The results indicate the cardioprotective effect of G. pedunculata against isoprenaline- induced myocardial infarction rat model. keywords: activity; changes; extract; group; infarction; isoprenaline; pedunculata; rats cache: bjp-24941.pdf plain text: bjp-24941.txt item: #422 of 942 id: bjp-24954 author: Sun, Jin-Jun; Kan, Shi-Feng; Sun, Guan-Xing title: Anti-cancer activity of midostaurin in hormone refractory human prostate cancer DU145 cells date: 2016 words: 3145 flesch: 59 summary: Midostaurin (100 nM) suppressed the growth of DU145 cells but without change in the number of dead cells. Midostaurin started to extend neurites on DU145 cells after 24 hours and differentiated into nerve cells by 72 hours. keywords: cancer; cells; differentiation; du145; midostaurin; prostate; protein; usa cache: bjp-24954.pdf plain text: bjp-24954.txt item: #423 of 942 id: bjp-24974 author: Rahim, Abdur; Hussain, Muhammad Medrar; Altaf, Ihsan Ullah Khan title: Phytochemical analysis and antimicrobial study of Fernandoa adenophylla against multidrug resistant urinary tract infection pathogens date: 2016 words: 4433 flesch: 49 summary: In the present study eight bacterial strains isolated from urine samples of UTI patients were used to test the antibacterial activities of plant extracts. Antibacterial activity of medicinal plant extracts. keywords: activity; adenophylla; extracts; strains; stretch cache: bjp-24974.pdf plain text: bjp-24974.txt item: #424 of 942 id: bjp-24975 author: Gong, Lu-Lu; Yang, Shu-Li; Zhang, Guo-Feng; Wu, Jia-Chengi; Lin, Rui-Xin title: Role of microRNA miR-34a in liver cancer stem cells date: 2016 words: 2349 flesch: 62 summary: The data correlates with the immunohistochemistry analysis and reveals that the sample obtained from the cancer patients contain liver cancer cells and obviously liver cancer stem cells. The present research focuses on the role of microRNA miR-34a in liver cancer stem cells. keywords: cancer; cd90; cells; liver; mir-34a; samples; stem; tissue cache: bjp-24975.pdf plain text: bjp-24975.txt item: #425 of 942 id: bjp-25031 author: Kim, Dusik ; Wang, Zheng ; Jin, Lili ; Li, Hanpin ; Hwang, Junwei ; Hanrahan, John  W.; Wang, Qiuyu title: Development of a novel antimicrobial peptide AWRK6 date: 2016 words: 5469 flesch: 50 summary: To understand the biodiversity and nature of antimicrobial peptides from this frog, we have previously used cDNA-sequencing and mass-spectrometry approaches to analyze the skin and its secretions, and identified dybowskin2-CDYa ( D y 2 ) , a n o v e l a n t It is well established that the killing activity and specificity of antimicrobial peptides depend on their physiochemical properties such as size, net charge, conformational structure and hydrophobicity (Mao et al., 2013). keywords: activity; awrk6; cells; dy2; gram; hours; killing; peptide; structure cache: bjp-25031.pdf plain text: bjp-25031.txt item: #426 of 942 id: bjp-25124 author: Jiang, Yu; Zhang, Rong-Rong; Yang, Li-Juan; Wu, Zhen; Chen, Huai-Ping; Zhao, Sai; Tian, Zhao-Fang title: Shenfu injection provides protection for perinatal asphyxia in neonates date: 2016 words: 2575 flesch: 56 summary: Eighty neonates with asphyxia were randomly divided into two groups, treatment group and control group (n=40). The neurobehavioral score was significantly higher in treatment group than in control group. keywords: asphyxia; control; day; group; injection; neonates; shenfu; treatment cache: bjp-25124.pdf plain text: bjp-25124.txt item: #427 of 942 id: bjp-25141 author: Hu, Shu-Hong; Yu, Hui; Gong, Xue-Qin; Zhang, Ying-Hong title: Trifluoromethyl-phenyl-triazolyl derivative of beta-bisabolol induces cell death in ME-180 cervical cancer cells through induction of apoptosis and ROS generation date: 2015 words: 3409 flesch: 55 summary: Cancer cell colony inhibition assay The colony formation by cancer cells in soft agar is an excellent and sensitive test to evaluate cell viability and cytotoxic potential. Trifluoromethyl-phenyl-triazolyl derivative of beta-bisabolol induces cell death in ME-180 cervical cancer cells through induction of apoptosis and ROS generation Shu-Hong Hu, Hui Yu, Xue-Qin Gong and Ying-Hong Zhang Department of Obstetrics, Yantai Yuhuangding Hospital, Shandong 264 000, P. R. China. keywords: apoptosis; beta; bisabolol; cancer; cells; hours; me-180; ros; triazolyl; ttb cache: bjp-25141.pdf plain text: bjp-25141.txt item: #428 of 942 id: bjp-25160 author: Shah, Palak A.; Shah, Gaurang B. title: Uricosuric activity of Tinospora cordifolia date: 2015 words: 3837 flesch: 52 summary: Treat- ment with aqueous extract and galo satwa resulted into significant increase in urinary uric acid level as com- pared to hydro-alcoholic and dichloromethane extract group (day 3 and 7). Urinary uric acid level was significantly higher in animals treated with galo satwa and aqueous extract as compared to hydro-alcoholic and dichloromethane extract treated groups. keywords: acid; alcoholic; animals; dichloromethane; extract; galo; hydro; red; satwa; uricosuric cache: bjp-25160.pdf plain text: bjp-25160.txt item: #429 of 942 id: bjp-25271 author: Akilandeswari, Krishnan; Ruckmani, Kandasamy title: Antibacterial potentiality of antiulcer and antispasmodic drugs with selected antibiotics against methicillin resistant Staphylococcus aureus: In vitro and in silico studies date: 2015 words: 4947 flesch: 47 summary: Bangladesh Journal of Pharmacology Research Article Antibacterial potentiality of antiulcer and antispasmodic drugs with se- lected antibiotics against methicillin resistant Staphylococcus aureus: In vitro and in silico studies BJP Introduction Microbes such as bacteria, viruses, fungi and parasites can cause virulent and contagious diseases in indivi- duals mainly through direct exposure to aerosols and contaminated materials (Barker and Jones, 2005). Article Info Received: 7 October 2015 Accepted: 16 October 2015 Available Online: 1 November 2015 DOI: 10.3329/bjp.v10i4.25271 Cite this article: Akilandeswari K, Ruckmani K. Anti- bacterial potentiality of antiulcer and antispasmodic drugs with selected antibiotics against methicillin re- sistant Staphylococcus aureus: In vitro and in silico studies. keywords: activity; ampicillin; antibiotics; aureus; drugs; mebeverine; mrsa; penicillin; protein; test; troxipide cache: bjp-25271.pdf plain text: bjp-25271.txt item: #430 of 942 id: bjp-25289 author: Ullah, Irfan; Khan, Jamshaid Ali; Adhikari, Achyut; Shahid, Muhammad title: Hepatoprotective effect of Monotheca buxifolia fruit against antitubercular drugs-induced hepatotoxicity in rats date: 2016 words: 5426 flesch: 57 summary: Materials and Methods Plant material Fruit of M. buxifolia was collected from the northern A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2016; 11: 248-256 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Information Expanded (SCIE), SCOPUS and Social Sciences Citation Index; ISSN: 1991-0088 Table III Effect of M. buxifolia extract on isoniazid plus rifampicin induced hepatotoxicity after 21 days of treatment Histopathological findings Group 1 Group 2 Group 3 Group 4 Group 5 Glycogen depletion – ++ + – – Congestion + +++ – + + Endothelium disruption – +++ – – – Sinusoidal dilatation – ++ – – – Hydropic degeneration – ++ – – – Cytolysis – + – – – Lymphocytic infiltration – ++ + – – Perivenular necrosis – ++ – – – Lymphoid aggregates in the portal tract – +++ – – – (–) none; (+) mild; (++) moderate; (+++) severe damage 252 Bangladesh J Pharmacol 2016; 11: 248-256 Dugasani SR, Saleem T, Sowjanya G, Gopinath C. Hepato- protective activity of methanolic extract of Mussaenda philippica (stems) against anti-tubercular drugs induced hepatotoxicity. keywords: buxifolia; compound; hepatoprotective; hepatotoxicity; isoniazid; rifampicin cache: bjp-25289.pdf plain text: bjp-25289.txt item: #431 of 942 id: bjp-25318 author: Jia, Youchao; Zang, Aimin; Feng, Yanguang; Li, Xiao-Fang; Zhang, Ke; Li, Hefei; Wang, Ruiyao; Wei, Yaning; Huo, Ran title: miRNA-486 and miRNA-499 in human plasma evaluate the clinical stages of lung cancer and play a role as a tumor suppressor in lung tumorigeneisis not pathogenesis date: 2016 words: 3349 flesch: 64 summary: The expression of miRNA- 499 and miRNA-486 in lung cancer patients were up-regulated, and might be closely related to the occurrence and prognosis of lung cancer, and might be used as potential screening and prognosis index for lung cancer. Abstract It was aimed to explore the expression level of miRNA-486 and miRNA-499 in the plasma of lung cancer patients and analysis their differences in expre- ssion. keywords: cancer; expression; lung; lung cancer; mir-486; mir-499; mirna-486; nsclc; patients; plasma; stage; tumor cache: bjp-25318.pdf plain text: bjp-25318.txt item: #432 of 942 id: bjp-25351 author: Rather, Irfan Ahmad; Bajpai, Vivek K.; Gyeong-Jun, Nam title: Mouse model of ulcerative colitis using trinitrobenzene sulfonic acid date: 2015 words: 1692 flesch: 50 summary: The clinical characteristics developed by TNBS colitis animal resemble to the UC patients in real life, which include frequent emptying of bowel, bloody stools, weight loss and inflammation in large bowel etc. One such efficient model is that of TNBS colitis, which is generated through the intra-rectal application of a compound 2,4,6-trinitrobenzene sulfonic acid (TNBS), very well known for its oxidizing and heptenating properties. keywords: colitis; disease; mice; model; tnbs cache: bjp-25351.pdf plain text: bjp-25351.txt item: #433 of 942 id: bjp-25371 author: Swamy, Mallappa Kumara; Sinniah, Uma Rani title: Phytochemical profile and in vitro alpha-amylase inhibitory potential of different solvent extracts of Lantana camara date: 2015 words: 895 flesch: 48 summary: In vitro α-amylase inhibitory potential of various solvent extracts (20-100 μg/mL) of L. camara leaves are shown in Figure 1. Phytochemical profile and in vitro α-amylase inhibitory potential of different solvent extracts of Lantana camara. keywords: amylase; camara; extracts cache: bjp-25371.pdf plain text: bjp-25371.txt item: #434 of 942 id: bjp-25427 author: Shukla, Shruti title: Studying antimicrobial-induced morphostructural damage of bacteria by Scanning Electron Microscope date: 2015 words: 1806 flesch: 38 summary: SEM-based visual approach is referred the study of bacterial cells and their physiological consequences when affected by antibiotics or antibacterial agents permitting the observation of characteristic morphological defects of cell wall, and provides valuable insights into processes involved in bacterial cell death. First Published: 24 October, 2015; Updated version: 1.0 DOI: 10.3329/bjp.v10i4.25427 ABSTRACT In this investigation, a scanning electron microscopy (SEM) method was used to examine the morphostructural changes in bacterial cells induced by antimicrobial agents. keywords: cell; ethanol; food; min; treatment cache: bjp-25427.pdf plain text: bjp-25427.txt item: #435 of 942 id: bjp-25462 author: Varadharajan, Venkatramanan; Shanmugam, Sethupathi; Ramaswamy, Arulvel title: Thrombolytic activity of the ethanolic extract of Vitis vinifera seeds date: 2015 words: 1121 flesch: 57 summary: Grape seed extract (GSE) is derived from whole grape seed and it is used as a nutraceutical agent (Zhu et al., 2015). For further thrombolytic experiments, the extract solution was prepared by dissolving 0.5 g of grape seed extract in 50 mL of 80% ethanol (10 mg/mL). keywords: clot; extract; grape; seed cache: bjp-25462.pdf plain text: bjp-25462.txt item: #436 of 942 id: bjp-25463 author: Kchaou, Mouna; Ben Salah, Hichem; Mhiri, Rania; Allouche, Noureddine title: Anti-oxidant and anti-acetylcholinesterase activities of Zygophyllum album date: 2015 words: 6118 flesch: 52 summary: Anti-oxidant activities Ferric-reducing anti-oxidant power assay The method of Yildirim et al. (2001) was used to assess the reducing power of all Z. album extracts. The presence of extract with anti-oxidant activity can hinder the extent of β-carotène bleaching by neutralizing the linoleate-free radical formed in the system (Barros et al., 2007). keywords: absorbance; acetylcholinesterase; acid; activities; activity; album; anti; dichloromethane; extracts; inhibition; methanol; total; zygophyllum cache: bjp-25463.pdf plain text: bjp-25463.txt item: #437 of 942 id: bjp-25469 author: Zhang, Long; Zhao, Wei; Xu, Qinfu; Zhao, Yumiao; Zhao, Junjie; Ren, Yin-long; Liu, Yu-jing; Li, Jing; Xu, Ai-Guo title: Non-invasive positive pressure ventilation offers greater improvement in COPD-related respiratory failure when combined with naloxone date: 2016 words: 3511 flesch: 51 summary: Before treatment, no differences were observed between treatment groups regarding PIP, PP, Pm, VE, or R (each p value >0.05, Table I). Therefore, NPPV now plays a proactive role in the improvement of acute respiratory failure in patients. keywords: copd; days; failure; group; naloxone; nppv; patients; pulmonary; treatment cache: bjp-25469.pdf plain text: bjp-25469.txt item: #438 of 942 id: bjp-25478 author: Ponnuswamy, Shekar; Kannaiyan, Sathish Kumar; Venugopal, Gopikrishnan; Mannikkam, Radhakrishnan title: HPTLC fingerprint profile of antibacterial compound produced from forest soil Streptomyces SFA5 date: 2016 words: 2509 flesch: 42 summary: A simple, sensitive and accurate HPTLC method has been performed for the quantitative estimation of bioactive compounds from ethyl acetate extract of Streptomyces sp. SFA5. Results of HPTLC finger printing of ethyl acetate extract of the strain SFA5 at UV 254 and 366 with corresponding Rf values substantiate the presence of bioactive compounds. keywords: acetate; ethyl; extract; hptlc; sfa5; streptomyces cache: bjp-25478.pdf plain text: bjp-25478.txt item: #439 of 942 id: bjp-25487 author: Bajpai, Vivek K.; Singh, Siddhartha; Mehta, Archana title: Chemical characterization and mode of action of Ligustrum lucidum flower essential oil against food-borne pathogenic bacteria date: 2016 words: 6879 flesch: 49 summary: Based on the susceptibility, L. lucidum flower oil revealed its mode of action on membrane integrity as confirmed by increased release of extra-cellular ATP (2.5 and 2.2 pg/mL), leakage of potassium ions (950 and 900 mM/L), loss of 260-nm absorbing materials (4.2 and 3.9 optical density), and increase in relative electrical conductivity (10.6 and 9.8%) against Staphylococcus aureus KCTC-1621 (Gram-positive) and Salmonella enterica ATCC-4731 (Gram-negative), respectively. Measurement of extracellular adenosine 5’-triphophate (ATP) concentration To determine the efficacy of L. lucidum flower oil on membrane integrity, the extracellular ATP concentra- tions were measured according to our previously described method (Bajpai et al., 2013). keywords: aureus; bacteria; essential; flower; flower oil; food; kctc-1621; l. lucidum; lucidum; lucidum flower; oil cache: bjp-25487.pdf plain text: bjp-25487.txt item: #440 of 942 id: bjp-25549 author: Wang, Fang; Wang, Yu-Hang; Wang, Jing-Jing; Xu, He-Lin; Wang, Chang-Miao title: Eriodictyol-induced anti-cancer and apoptotic effects in human hepatocellular carcinoma cells are associated with cell cycle arrest and modulation of apoptosis-related proteins date: 2016 words: 3262 flesch: 49 summary: Figure 3 shows the cytotoxic effect of eriodictyol against AML12 normal liver hepatocyte cells which reveals that the compound showed very less cytotoxicity against normal cells indicating that eriodictyol is a selective cytotoxic agent against cancer cells. The present study indicates that eriodictyol at almost all doses selectively targets cancer cells without causing too much damage to AML12 normal liver hepatocyte cells. keywords: apoptosis; cancer; cells; cycle; eriodictyol; hep; liver cache: bjp-25549.pdf plain text: bjp-25549.txt item: #441 of 942 id: bjp-25633 author: Mingsan, Miao; Yan, Li; Tan, Wang; Ting, Wang; Ming, Bai; Jinxin, Miao; Bao, Gong title: Effects of motherwort alkaloids on rat ear acne date: 2016 words: 2806 flesch: 53 summary: High dose of TALH group rats auricle partial skin squamous epithelial cells did not show proliferous thickening. Medium dose of TALH group rats auricle partial skin squamous epithelial cells did not show proliferous thickening. keywords: acne; auricle; dose; group; model; motherwort; rats; talh cache: bjp-25633.pdf plain text: bjp-25633.txt item: #442 of 942 id: bjp-25634 author: Wang, Li; Yang, Tingting; Ju, Weiping; Ren, Ming; Feng, Zhanqin; Zheng, Zengjuan; Hu, Zhenbo; Liu, Yuqing; Zhang, Weifen title: Degradation behavior of theophylline/chitosan/β-cyclodextrin microspheres for pulmonary drug delivery date: 2016 words: 3922 flesch: 54 summary: Figure 4: In vitro degradation curves of microspheres system in 0.2 mg/mL lysozyme solutions (mean ± SD, n=5) 25 KV 900 X 100 µM KYKY: 2800B SEM SN: 0602 25 KV 3.50 KX 10 µM KYKY: 2800B SEM SN: 0600 Figure 5: SEM of MS B degradation in 0.2 mg/mL lysozyme solutions after 12 weeks S120 Bangladesh J Pharmacol 2016; 11: S116-S122 solution (Figure 1 and Figure 4). Then the specimens were weighed, and the degree of degradation was estimated from degradation rate of microspheres as following equation: Where M0 is the initial weight of the microspheres and Mt is the weight of the microspheres after the incubation keywords: cts; degradation; figure; lysozyme; microspheres; weeks; weight cache: bjp-25634.pdf plain text: bjp-25634.txt item: #443 of 942 id: bjp-25638 author: Miao, Mingsan; Wang, Tan; Li, Yan; Li, Min; Guo, Lin; Zhang, Ying title: Effect of Cynomorium flavonoids on mouse model of perimenopausal depression date: 2016 words: 2954 flesch: 53 summary: The large dose of Cynomorium flavonoids group could obviously extend the avoiding latency of dark avoidance method experiment (p<0.05). The large, middle dose of Cynomorium flavonoids group and the Gengnian’an capsule group could significant reduce the number of being shocked in the dark avoidance method experiment (p<0.01). keywords: cynomorium; depression; dose; flavonoids; group; mice; model; perimenopausal cache: bjp-25638.pdf plain text: bjp-25638.txt item: #444 of 942 id: bjp-25639 author: Wang, Gang-Ping; Chen, Ying; An, Bai-Li; Zhao, Ying; Sui, Bei-Bei; Min, Peng-Xiang; Zhao, Yun; Liang, Yun-Ai; Zhao, Yi-Nuo title: COX-2 expression correlation with invasion in human breast carcinomas and in cell line MDA-MB-231 in vitro date: 2016 words: 7595 flesch: 39 summary: The role for COX-2 on breast cancer is not fully clear, and studies have shown that the proliferation and metastasis of breast cancer cells is a very complex, multistep process, affected by various factors including genetic and so on (Miglietta et al., 2010; Yu et al., 2014). Bangladesh J Pharmacol 2016; 11: S43-S54 S49 studies have shown that the proliferation and metastasis of breast cancer cells is a very complex, multistep process, affected by various factors including the common role of environmental, genetic and so on (Sueoka et al., 2013). keywords: breast; breast cancer; cancer; cells; cox-2; et al; expression; invasion; mb-231; mda; metastasis; patients; results; rna; study; survival; tumor; vegf cache: bjp-25639.pdf plain text: bjp-25639.txt item: #445 of 942 id: bjp-25692 author: Aslam, Muhammad title: Forced swim test in mice: A common animal model of depression date: 2015 words: 971 flesch: 59 summary: 2016; 11: 28-29 VISUAL EXPERIMENT Forced swim test in mice: A common animal model of depression Muhammad Aslam Department of Basic Medical Sciences, Faculty of Pharmacy, Ziauddin University, Karachi 75600, Pakistan. In the forced swimming test, mice are constrained to swim in a restricted space from which they can't escape, and are activated to a particular behavior of immobility. keywords: mice; tank; test cache: bjp-25692.pdf plain text: bjp-25692.txt item: #446 of 942 id: bjp-25731 author: Ajani, Olayinka Oyewale; Aderohunmu, Damilola Victoria; Umeokoro, Ejike Nzube; Olomieja, Ayodele Ojo title: Quinazoline pharmacophore in therapeutic medicine date: 2016 words: 11703 flesch: 53 summary: Gefitinib and erlotinib are quinazoline-based compounds which happened to be earlier reported salient EGFR inhibitor authorized for the curing of diseases related to NSCLC (Wang et al., 2016). Their mechanism of action was through competi- tive binding to adenosine triphosphate (ATP)-binding pocket of the intracellular EGFR TK site according to docking study report; hence, effectively block the aberrant EGFR down-stream signaling required during tumor survival as well as its proliferation (Wang et al., 2016; Hynes and Lane, 2005). keywords: activities; activity; agents; anti; anticonvulsant; antimalarial; antitumor; bangladesh; bioorg; cancer; cell; chem; derivatives; design; drug; egfr; et al; eur; evaluation; figure; inhibitors; j chem; j med; kinase; med; med chem; molecular; motifs; new; novel; pharmacol; potential; quinazoline; quinazoline derivatives; series; studies; study; synthesis; wang; zhang cache: bjp-25731.pdf plain text: bjp-25731.txt item: #447 of 942 id: bjp-25754 author: Wang, Gui-Qi; Gu, Jing-Feng; Gao, Ying-Chao; Dai, Yong-Jun title: Daucosterol inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway date: 2016 words: 4042 flesch: 55 summary: Further since cell migration and cell invasion are two key parameters of cancerous cells, it was seen in the present study that daucosterol is a potent inhibitor of cell migration and cell invasion indicating its ability to restrict cancer cells within a specified range. Invasion of cancer cells into neigh- boring tissue and the vasculature is a primary step in tumor metastasis. keywords: apoptosis; cancer; cells; colon; control; daucosterol; hct-116; invasion; migration cache: bjp-25754.pdf plain text: bjp-25754.txt item: #448 of 942 id: bjp-25762 author: Bajpai, Vivek K.; Rather, Irfan A.; Nam, Gyeong-Jun title: Experimental strategy of animal trial for the approval of anti-diabetic agents prior to their use in pre-human clinical trials date: 2015 words: 1992 flesch: 47 summary: In the present article, we demonstrated some standard handling procedure of animal trial for the approval of anti-diabetic drug, which could be helpful for both academics and industrial scientific community to conduct the animal experiments. Surgical gloves Surgical masks Soft sterilized lancets Sterilized distilled water Major equipments Cannula for oral drug administration Glucometer and glucose test strips Weighing machine Paraformaldehyde (4%) for tissue preservation Freezer (-70ºC for preservation of animal tissue slides until further analysis) Streptozotocin (STZ) from Sigma Pioglitazone (standard anti-diabetic drug) Test drug sample Ethanol PREPARATION OF REAGENTS Citrate buffer solution 0.1M (pH 2.5) keywords: animal; diabetes; diabetic; drug; mice; streptozotocin cache: bjp-25762.pdf plain text: bjp-25762.txt item: #449 of 942 id: bjp-25777 author: Naz, Syeda Batool; Chaudhry, Mueen Ahmad; Rahaman, Muhammad Shafeeq Ur title: Dual receptors blocked mechanism arbitrates smooth muscles relaxant effect of Polypodium vulgare date: 2016 words: 4298 flesch: 54 summary: Crude extract of P. vulgare was also analyzed in vivo, because anti-cholinergic drugs and Ca2+ channel blocker are acknowledged to be beneficial in diarrhea (Brown and Taylor, 2006) and the speculation was strengthened when crude extract showed concentration dependent (300 and 500 mg/Kg) protection against castor oil induced diarrheal mice, comparable to dicyclomine. A rightward shift in carbachol cumulative response curves was observed in the presence of crude extract (1-3 mg/mL), similar to dicyclomine. keywords: anti; carbachol; crude; dicyclomine; effect; extract; vulgare cache: bjp-25777.pdf plain text: bjp-25777.txt item: #450 of 942 id: bjp-25796 author: Shukla, Shruti title: A Bradford multiplexing method for protein estimation in fermented foods: Soy sauces date: 2015 words: 1429 flesch: 53 summary: Soy protein is a major component of the diet of food and is increasingly important in the human diet. Hence, here in the present article, we are focusing a rapid and easy method for quantitative determination of total protein content with multiplex samples in any food products such as soy sauce or other traditional fermented foods. keywords: food; protein; sauce; soy cache: bjp-25796.pdf plain text: bjp-25796.txt item: #451 of 942 id: bjp-25818 author: Rohman, Mohammad Saifur; Fahrany, Frastiqa; Maslahah, Imama; Widodo, -; Lukitasari, Mifetika; Kurniawan, Aditya; Endharti, Agustina Tri title: REN C-5312T, but not C-5434T, correlates to increase serum angiotensin I level in angiotensin II receptor blockers-treated hypertensive patients date: 2016 words: 3759 flesch: 55 summary: Serum angiotensin I levels between CC and CT/TT genotype of REN-5434 polymorphism The comparation of serum angiotensin I level among genetic variant of C-5434T REN polymorphism were analyzed, either in hypertensive patients carrying -5312 CC or -5312 CT/TT genotype. Previous study showed that there was a significant elevation of serum angiotensin I levels among hyper- tensive patients with REN C-5312T after receiving valsartan (Konoshita et al., 2009), even if they did not investigate REN C-5434T polymorphism. keywords: angiotensin; arb; c-5312; level; ren; serum cache: bjp-25818.pdf plain text: bjp-25818.txt item: #452 of 942 id: bjp-25851 author: Bairy, Partha Sarathi; Das, Aparoop; Nainwal, Lalit Mohan; Mohanta, Tapan Kumar; Kumawat, Mukesh Kumar; Mohapatra, Pradyumna Kishore; Parida, Pratap title: Design, synthesis and anti-diabetic activity of some novel xanthone derivatives targeting alpha-glucosidase date: 2016 words: 6989 flesch: 62 summary: Blood glucose level on 0 day 5th day 10th day 15th day Normal control 0.3% CMC 91 ± 0.4 102 ± 0.5 102.6 ± 1.1 96.4 ± 0.7 Diabetic control 242.6 ± 1.1 264.8 ± 1.5 270 ± 2.3 270 ± 0.5 Standard (miglitol) 25 286.6 ± 7.4 228.26 ± 7.2c 181.0 ± 6.0ac 121.7 ± 6.7ac 100 273.4 ± 14.1 228.8 ± 10.1c 182.9 ± 12.8ac 131.3 ± 6.3ac P22 250 285.4 ± 6.0 232.4 ± 7.7c 182.0 ± 11.8ac 136.4 ± 8.3ac P10 100 283.9 ± 15.9 228.9 ± 13.7c 167.8 ± 9.9ac 133.5 ± 5.9ac 250 275.4 ± 7.6 220.7 ± 6.3c 181.0 ± 6.0ac 133.3 ± 4.6ac P2 100 275.5 ± 9.5 232.0 ± 9.4c 179.7 ±10.0ac 127.8 ± 10.2ad Table IV Effect on body weight of the synthesized compounds Group Dose (mg/kg,p.o) 0 day 5th day 10th day 15th day Normal control 0.3% CMC 190.6 ± 2.8 191.6 ± 2.8 192.6 ± 2.8 195.6 ± 2.4 Diabetic control 182.4 ± 1.5 181.2 ± 1.6 176.6 ± 2.3 184.4 ± 2.2 Standard (miglitol) 25 148.1 ± 8.4 146.1 ± 8.3ac 142.4 ± 8.1ac 134.4 ± 9.3ac P22 100 147.7 ± 8.7a 146.2 ± 8.8ac 144.2 ± 8.2ac 142.7 ± 8.1ac 250 142.4 ± 7.4a 140.6 ± 7.5ac 138.3 ± 7.4ac 136.8 ± 7.2ac P10 100 143.6 ± 8.7a 141.6 ± 8.3ac 140.1 ± 8.0ac 138.7 ± 8.0ac 250 144.5 ± 6.7a 141.5 ± 6.8ac 139.4 ± keywords: activity; animals; blood; compounds; control; day; docking; et al; glucose; group; level; ligand; protein; xanthone cache: bjp-25851.pdf plain text: bjp-25851.txt item: #453 of 942 id: bjp-25859 author: Merugumolu, Vijay Kumar; Chandrashekara, Revanasiddappa Bistuvalli title: Synthesis and anti-depressant evaluation of novel pyrazolone derivatives date: 2016 words: 3993 flesch: 62 summary: Owing to the above pharmacological activities exhibited by pyra- zolones, it was contemplated to synthesize a novel series of pyrazolone derivatives and their subsequent in vivo anti-depressant activity. Animals Male Swiss albino mice (25-30 g) were used for screen- ing of anti-depressant activity, of the newly synthesized compounds. keywords: activity; anti; compounds; derivatives; pyrazolone; test cache: bjp-25859.pdf plain text: bjp-25859.txt item: #454 of 942 id: bjp-25862 author: Bajpai, Vivek K.; Rather, Irfan A.; Hamad, Alshammari Fanar title: Purification of bacteriocins using size-exclusion chromatography date: 2016 words: 1306 flesch: 54 summary: Before adding sample to dialysis membrane, it is highly recommended to wash the membrane with ultrapure water or buffer for at least 30 min to remove contaminants such as sulfur, heavy metals and glycerol to avoid any possible effects of these components on sample. There are some critical points to take care of during ammonium sulfate precipitation. keywords: buffer; dialysis; membrane; sample cache: bjp-25862.pdf plain text: bjp-25862.txt item: #455 of 942 id: bjp-25936 author: Varadharajan, Venkatramanan; Shanmugam, Sethupathi; Ramaswamy, Arulvel title: Correlation between the total phenolics, proanthocyanidins content and anti-oxidant activity of grape seed extract date: 2016 words: 1325 flesch: 50 summary: Correlation between the total phenolics, proanthocya- nidins content and anti-oxidant activity of grape seed extract Sir, The therapeutic properties of grape seed extract are invaluable assets to human beings. In conclusion, a positive correlation was observed between total phenolics, proanthocyanidins content and anti-oxidant activity of grape seed extract. keywords: activity; dpph; extract; grape; seed cache: bjp-25936.pdf plain text: bjp-25936.txt item: #456 of 942 id: bjp-25981 author: Akacha, Maroua; Lahbib, Karima; Boughanmi, Néziha Ghanem title: Phytochemically evaluation and net antioxidant activity of Tunisian Melia azedarach leaves extract from their ProAntidex parameter date: 2016 words: 4127 flesch: 58 summary: Evaluation of anti-oxidant activity of extracts DPPH assay In fact, Siger et al. (2013) and Gaspar et al. (2010) showed anti-oxidant activity of sinapic acid as one of the four most common hydroxycinnamic acids and its derivatives. keywords: absorbance; acid; acont; activity; anti; azedarach; extract; leaves; phenolic; scavenging cache: bjp-25981.pdf plain text: bjp-25981.txt item: #457 of 942 id: bjp-25991 author: Dobhal, Yogita; Parcha, Versha; Dhasmana, D. C. title: Characterization of new cardioprotective principle isolated from methanolic extract of Allium humile leaves from Himalayan region date: 2016 words: 3564 flesch: 56 summary: Chromato- graphic purification of the methanolic extract of A. humile leaves isolated ajoene (enol form) 980 g of powder of A. humile leaves were extracted with petroleum ether, chloroform, acetone and methanol successively using soxhlet apparatus. keywords: ah-1; compound; effect; effluent; extract; humile; leaves; myocardial; release; reperfusion cache: bjp-25991.pdf plain text: bjp-25991.txt item: #458 of 942 id: bjp-26001 author: Sellem, Imen; Kaaniche, Fatma; Chakchouk, Ahlem Mtibaa; Mellouli, Lotfi title: Anti-oxidant, antimicrobial and anti-acetylcholinesterase activities of organic extracts from aerial parts of three Tunisian plants and correlation with polyphenols and flavonoids contents date: 2016 words: 10707 flesch: 66 summary: Correlation between the phenolic and the flavonoids contents and biological activities in plant extracts were analysed by Pearson correlation coefficient. Rauha JP, Remes S, Heinonen M, Hopia A, Kähkönen M, Kujala T, Pihlaja K, Vuorela H, Vuorela P. Antimicrobial effects of finnish plant extracts containing flavonoids and other phenolic compounds. keywords: activities; activity; anti; extracts; plants cache: bjp-26001.pdf plain text: bjp-26001.txt item: #459 of 942 id: bjp-26024 author: Ergene Öz, Burçin; Ilhan, Mert; Ozbilgin, Serkan; Küpeli Akkol, Esra; Bahadir Acikara, Özlem; Saltan, Gülçin; Keles, Hikmet; Süntar, Ipek title: Effects of Alchemilla mollis and Alchemilla persica on the wound healing process date: 2016 words: 5216 flesch: 59 summary: The extracts prepared from the aerial parts of A. mollis and A. persica exerted significant wound healing activity with the tensile strength values of 39.3% and 33.3%, respectively, and with the contraction values of 51.4% and 43.5%, respectively. In the present study, wound healing activity of A. mollis and A. persica, both of which have quite similar phytochemical profile according to our previous research (Kupeli Akkol et al., 2015), were selected in order to be evaluated by using in vivo wound models. keywords: + +; a. mollis; activity; extracts; healing; mollis; parts; persica; r +; wound cache: bjp-26024.pdf plain text: bjp-26024.txt item: #460 of 942 id: bjp-26101 author: Rafique, Nayyab; Khan, Taous; Shah, Abdul Jabbar title: Calcium entry blocking activity of the Elaeagnus umbellata fruit extract explains its use in diarrhea and gut spasm date: 2016 words: 4325 flesch: 55 summary: Crude extract of E. umbellata, which was found positive for flavonoids, terpenoids and tannins, provided 9.9-71.9% protection in castor oil-induced diarrhea in mice, like verapamil. In isolated rabbit jejunum preparations, crude extract caused inhibition of spontaneous and high K+-induced contractions, with respective EC50 values of 0.3 (0.1-0.5) and 0.5 mg/mL, suggesting Ca2+ channel blockade (CCB). keywords: concentration; crude; diarrhea; effect; extract; umbellata; verapamil cache: bjp-26101.pdf plain text: bjp-26101.txt item: #461 of 942 id: bjp-26149 author: Sunil Kumar, K. N.; Rajakrishnan, R.; Thomas, J.; Reddy, G. Aadinaath title: Hepatoprotective effect of Helicanthus elastica date: 2016 words: 4538 flesch: 56 summary: Ethanolic extract, aqueous extract, paracetamol and silymarin were suspended with 1% sodium carboxyl methyl cellulose. Paracetamol 2 g/kg 157.8 ± 20.4 49.8 ± 09.6b 304.2 ± 28.4 5.7 ± 0.3b 0.7 ± 0.1 Data are mean ± SEM; ap<0.05, when compared with normal control, bp<0.05, when compared with paracetamol control (Tuckey- Kramer test); HEAq, Aqueous extract of H. elastica; HEAl, Ethanolic extract of H. elastica; ALP, Alkaline phosphatase; SB, Serum bilirubin; SGOT, Serum glutamate oxaloacetate transaminase; SGPT, Serum glutamate pyruvate transaminase; TP, Total protein Figure 1: Histopathological study of liver in paracetamol- induced hepatotoxicity in rats (a) Normal control; (b) Paraceta- mol 2,000 mg/kg treated; (c) Silymarin 100 mg/kg treated; (d) keywords: activity; body; changes; dose; elastica; extract; level; liver; paracetamol; rats; weight cache: bjp-26149.pdf plain text: bjp-26149.txt item: #462 of 942 id: bjp-26181 author: Waqar, Huma; Khan, Humaira Majeed; Anjum, Aftab Ahmad title: Antiepileptic potential of Silybum marianum seeds in pentylenetetrazol-induced kindled mice date: 2016 words: 4478 flesch: 57 summary: Treatment group A (100 mg/kg), B (200 mg/kg) and C (300 mg/kg) significantly increased SOD activity up to 0.2 ± 0.7 µmol/mg protein, 0.3 ± 0.1 µmol/mg protein and 0.4 ± 0.1 µmol/mg protein respectively when compared to induced group (p<0.05). By injecting sub convulsion dose of pentylenetetrazol alternately, progressive increase in convulsion scores was recorded in induced group. keywords: activity; day; group; marianum; mice; pentylenetetrazol; reference; treatment cache: bjp-26181.pdf plain text: bjp-26181.txt item: #463 of 942 id: bjp-26327 author: Rajasekar, Thirunavukkarasu; Anbarasu, Sivaraj; Radhakrishnan, Manikkam; Jerrine, Joseph; Vanaja, Kumar title: In vitro antitubercular activity of Tridax procumbens extracts against whole cell Mycobacterium tuberculosis and its lysine aminotransferase date: 2016 words: 814 flesch: 47 summary: Bangladesh J Pharmacol. A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2016; 11: 192-193 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088; DOI: 10.3329/bjp.v11i1.26327 Letter to the Editor Table keywords: activity; extracts; tuberculosis cache: bjp-26327.pdf plain text: bjp-26327.txt item: #464 of 942 id: bjp-26329 author: Gopikrishnan, Venugopal; Radhakrishnan, Manikkam; Pazhanimurugan, Raasaiyah; Shanmugasundaram, Thangavel; Balagurunathan, Ramasamy title: In vitro antimicrobial activity of actinobacteria from South East Coast of Tamil Nadu, India date: 2016 words: 728 flesch: 36 summary: 191 Bangladesh J Pharmacol 2016; 11: 190-191 Table I Antagonistic activity of potential actinobacterial strains PM 33 and PE7 Clinical pathogens (Zone of inhibition in mm) Actinobacterial strains S. aureus B. subtilis E. coli P. aeruginosa K. pneumoniae Strain PM33 15 ± 0.58 16 ± 0.58 14 ± 0.00 16 ± 0.58 14 ± 0.00 Strain PE7 15 ± 0.58 17 ± 0.00 12 ± 0.58 16 ± 0.58 13 ± 0.58 mailto:rbalaguru@yahoo.com DatePrinted: This article was downloaded by you on: Jan 18, 2016 After 10 days of incubation all the actinobacterial cultures were screened for antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae by agar plug method (Radhakrishnan et al., 2014). keywords: actinobacteria; activity; strains cache: bjp-26329.pdf plain text: bjp-26329.txt item: #465 of 942 id: bjp-26333 author: Baratloo, Alireza; Bafarani, Sara Arab; Forouzanfar, Mohammad Mehdi; Hashemi, Behrooz; Friedman, Benjamin Wolkin; Abdalvand, Ali title: Intravenous caffeine versus intravenous ketorolac for the management of moderate to severe migraine headache date: 2016 words: 3209 flesch: 56 summary: Shahrami A, Assarzadegan F, Hatamabadi HR, Asgarzadeh M, Sarehbandi B, Asgarzadeh S. Comparison of therapeutic effects of magnesium sulfate vs. dexamethasone/metoclo- pramide on alleviating acute migraine headache. Abstract The aim of this study was to determine if intravenous caffeine is as effective as intravenous ketorolac for the treatment of moderate to severe migraine headaches. keywords: caffeine; group; ketorolac; migraine; pain; patients; study cache: bjp-26333.pdf plain text: bjp-26333.txt item: #466 of 942 id: bjp-26369 author: Canli, Kerem; Altuner, Ergin Murat; Akata, Ilgaz; Turkmen, Yavuz; Uzek, Ugur title: In vitro antimicrobial screening of Lycoperdon lividum and determination of the ethanol extract composition by gas chromatography/mass spectrometry date: 2016 words: 4392 flesch: 53 summary: The ethanol extract of L. lividum had antimicrobial activity against several microorganism tested, but it was active especially against S. carnosus. Table I clearly shows that ethanol extracts of L. lividum 390 Bangladesh J Pharmacol 2016; 11: 389-394 were presented antimicrobial activity against E. aerogenes, E. coli ATCC 25922, K. pneumoniae, S. kentucky, S. carnosus, S. epidermidis and S. agalactiae. keywords: acid; activity; antimicrobial; atcc; coli; composition; et al; ethanol; extract; fatty; gram; lividum cache: bjp-26369.pdf plain text: bjp-26369.txt item: #467 of 942 id: bjp-26410 author: Qin, Zhao-Yang; Guo, Xiao-Yan; Xu, Jing-Zhong; Wang, Gang-Ping title: Cyclooxygenase-2 expression and its association with vascular endothelial growth factor, microvessel density and clinicopathologic characteristics of colorectal carcinoma date: 2016 words: 4126 flesch: 29 summary: The expressions of COX-2 in different groups were shown in Table I. Immunohistochemical analysis revealed COX-2 expression in CRC tissue was significantly higher than that in dysplasia and normal colorectal mucosa specimens (p<0.05). COX-2 expression was detected by means of immunohistochemistry in a series of human tissue samples with CRC (n = 120), dysplasia tissue closely adjacent to carcinomas (n = 40) and normal colorectal mucosa (n = 40), and their expressions association with vascular endothelial growth factor (VEGF), CD31-labeled micorvessel density (MVD) in CRC and other clinicopathologic characteristics were investigated. keywords: cancer; cox-2; crc; expression; groups; metastasis; mvd; patients; tumor cache: bjp-26410.pdf plain text: bjp-26410.txt item: #468 of 942 id: bjp-26411 author: Shi, Mingxian; Chen, Rui; Guo, Cen; Gao, Li title: Influence of ketamine on amino acid neurotransmitters secretion by nerve cells in vitro date: 2016 words: 3513 flesch: 51 summary: Up to now, little is known about their effects on nerve cells in vitro. Cite this article: Shi M, Chen R, Guo C, Gao L. Influ- ence of ketamine on amino acid neu- rotransmitters secretion by nerve cells in vitro. keywords: acid; amino; cells; concentration; glutamate; ketamine; nerve cache: bjp-26411.pdf plain text: bjp-26411.txt item: #469 of 942 id: bjp-26412 author: Wang, Xiaonan; Li, Xihai; Yang, Jie; Yu, Ming; Wu, Jinmei title: Amyloid precursor protein in peripheral granulocytes as a potential biomarker for Alzheimer's disease date: 2016 words: 3861 flesch: 52 summary: Blennow K, Hampel H, Weiner M, Zetterberg H. Cerebro- spinal fluid and plasma biomarkers in Alzheimer disease. The amyloid precursor protein of Alzheimer disease in human brain and blood. keywords: alzheimer; amyloid; app; blood; disease; expression; granulocytes; patients; peripheral; precursor; protein cache: bjp-26412.pdf plain text: bjp-26412.txt item: #470 of 942 id: bjp-26413 author: Yu, Dujuan; Tan, Ping; Yu, Min; Shi, Shaomin; Wang, Xue title: EGR1, EGFR and IGF1R protein expressions in non-small cell lung cancer and their clinical significances date: 2016 words: 3896 flesch: 52 summary: EGFR protein expression was correlated with the pathological subtype, pathological stage and smoking history. Data are given as correlation coefficient (p value), and ap<0.05 indicates statistically significant difference Figure 3: Survival analysis of lung cancer biomarkers in NSCLC Note: Kaplain-Meier test and log-rank test was used to evaluate how the NSCLC survival was impacted by the overexpression of biomarkers EGR1, EGFR and IGF1R in tumor tissues, or the overexpression of pErk and pAkt in paracancer tissues EGFR protein expression was correlated with the pathological subtype, pathological stage and smoking history, but was not correlated with survival. keywords: cancer; cell; egfr; egr1; expression; igf1r; lung; nsclc; protein; tissues cache: bjp-26413.pdf plain text: bjp-26413.txt item: #471 of 942 id: bjp-26414 author: Wang, Jinpeng; Zhang, Lian; Jin, Zhengyu title: Separation and purification of low-molecular-weight chondroitin sulfates and their anti-oxidant properties date: 2016 words: 3924 flesch: 49 summary: Conclusion Low-molecular-weight chondroitin sulfate was firstly separated, purified and identified as disaccharide, tetrasaccharide and hexasaccharide, which showed higher anti-oxidant activity than chondroitin sulfate. The main compo- nents detected by high performance gel-filtration chromatography were disaccharide, tetrasaccharide, hexasaccharide with molecular weight of 521, 1024 and 1527 Da, respectively. keywords: activity; anti; chondroitin; chondroitin sulfate; gel; separation; sulfate; weight; weight chondroitin cache: bjp-26414.pdf plain text: bjp-26414.txt item: #472 of 942 id: bjp-26415 author: Zhao, Songfeng; Zhang, Xiao; Zhang, Xiaojian; Shi, Xiuqin; Li, Jun; Kan, Quancheng; Yang, Shuoye title: Preparation and release characteristics study on the novel minocycline hydrochloride sustained-release capsule date: 2016 words: 3526 flesch: 50 summary: These new pharmaceutical preparations can exhibit drug release constantly at a steady rate, the slow and sustained A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2016; 11: S36-S42 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index; ISSN: Drug release study for sustained-release capsule The dissolution curve of developed formulation in 12 batches in hydrochloric acid solution was shown in Figure 4. keywords: dissolution; drug; hours; hydrochloride; minocycline; release; samples; solution; time cache: bjp-26415.pdf plain text: bjp-26415.txt item: #473 of 942 id: bjp-26416 author: Zheng, Chenglong; Yang, Panchu; Zhang, Lu; Wang, Zhiyong; Chen, Kun; Lan, Yue; Zhai, Xing; Huang, Kun; Guo, Shuwen title: Angiogenesis and expression of vascular endothelial growth factor and endostatin protein in myocardial infarction rat model date: 2016 words: 4337 flesch: 47 summary: Data are mean ± SD; n=11; One-way analysis of variance, compared with the sham group at the same time, ap<0.05，bp<0.01; compared with the model group at the same time, cp<0.05; compared with the same group at 1th week, dp<0.05 compared with the same group at 2th week, ep<0.0 compared with the TXL group at the same time, fp<0.05 S4 Bangladesh J Pharmacol 2016; 11: S1-S7 endostatin protein expression of qi group, blood group, 1:2 group, 2:1 group and TXL group was significantly higher at second week than the first week (p>0.05),however, there were statistical significances between the 4th week and 2nd week, which was higher than sham group and model group at the same time (p<0.05). Compared with the model group, the vascular endothelial growth factor expression of qi group, blood group, 1:2 group, 2:1 group and TXL group was significantly higher (p<0.05). keywords: blood; blood group; expression; factor; group; growth; infarction; model group; sham; time cache: bjp-26416.pdf plain text: bjp-26416.txt item: #474 of 942 id: bjp-26417 author: Yang, Shuoye title: Preparation and evaluation of novel galantamine hydrobromide sustained-release capsule date: 2016 words: 6015 flesch: 39 summary: Drug release mechanism and statistical analysis for release data Drug release data were analyzed by various mathema- tical models. In vitro and in vivo evaluation of ofloxacin sustained release pellets. keywords: analysis; capsules; dissolution; drug; galantamine; galantamine hydrobromide; hydrobromide; medium; method; reference; release; results; samples; study; testing; time cache: bjp-26417.pdf plain text: bjp-26417.txt item: #475 of 942 id: bjp-26418 author: Xu, Tao; Zhao, Na; Liu, Jing-Dong; Xiao-Mei, Mo; Zhang, Hui; Qin, Peng-Fei; Feng, Xiang-Chun; Sun, Qing title: Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTOR date: 2016 words: 5373 flesch: 47 summary: 21 Shame-surgery group HIE model group Shame acupuncture group Acupuncture group Antagonist group Antagonist and acupuncture group F A1 A3 A7 A21 B1 B3 B7 B21 C1 C3 C7 C21 D1 D3 D7 D21 E1 E3 E7 E21 Figure 1: Effect of electroacupuncture treatment on neuronal damage in the injured cortex of rat with HIE (Hematoxylin-eosin staining , optical microscope, ×200). Bangladesh J Pharmacol 2016; 11: S98-S105 S103 apoptosis and promote neurological functional recovery in a focal cerebral ischemia-reperfusion injured rat model (Lan et al., 2013; Hong et al., 2013; Chen et al., 2012; Zhao et al., 2010). keywords: cell; day; electroacupuncture; et al; expression; group; hie; model; model group; mtor; protein; rats; treatment cache: bjp-26418.pdf plain text: bjp-26418.txt item: #476 of 942 id: bjp-26419 author: Shi, Guo-Qing; Yang, Jing; Liu, Jiang; Liu, Sheng-Nan; Song, Han-Xue; Zhao, Wen-En; Liu, Yan-Qi title: Isolation of flavonoids from onion skins and their effects on K562 cell viability date: 2016 words: 5527 flesch: 59 summary: It suggests that ortho hydroxyl groups on B ring of onion flavonoids might be the key structural elements of their cytotoxic effects on K562 cells, and hydroxyl groups in position 3 or carbonyl groups in position 4 might be one of the structural effect elements. The isolation and identification of flavonoids from onion skin would not only enhance our understanding of the material basis for their biological activities, but could also provide a theoretical basis for the utilization of these compounds in a number of other areas of research. keywords: cells; cm-1; compound; flavonoids; k562; nmr; onion; quercetin; skins cache: bjp-26419.pdf plain text: bjp-26419.txt item: #477 of 942 id: bjp-26438 author: Ravisankar, Narayanan; Joseph, Jerrine; Radhakrishana, Manikkan; Rajasekar, Thirunavukkarasu title: In vitro cytotoxicity of methanol extracts of Hypericum wightianum and Hypericum hookerianuim against 3T3L1 cell lines date: 2016 words: 992 flesch: 49 summary: The extracts also exhibited moderate cytotoxicity against cancer cell lines, among the cancer cell lines. From the study, it was observed that extracts showed moderate cytotoxic against both cancer and normal cell lines. keywords: cell; cytotoxicity; extracts; hypericum cache: bjp-26438.pdf plain text: bjp-26438.txt item: #478 of 942 id: bjp-26471 author: Hidayat, Meilinah; Prahastuti, Sijani; Fauziah, Nurul; Maesaroh, Maesaroh; Balqis, Balqis; Widowati, Wahyu title: Modulation of adipogenesis-related gene expression by ethanol extracts of Detam 1 soybean and Jati belanda leaf in 3T3-L1 cells date: 2016 words: 3952 flesch: 50 summary: Ethanol extract of Jati belanda at a concentration of 50 μg/ mL was most effective to reduce PPAR , C/EBP , and SCD1 gene expression in 3T3-L1 cells. SCD1 gene expression In this research, EEJB and EEDS at the concentration of 50 µg/mL showed lower SCD1 gene expression by approximately twice than positive control (Figure 3). keywords: 3t3; cells; eeds; eejb; ethanol; expression; gene; soybean cache: bjp-26471.pdf plain text: bjp-26471.txt item: #479 of 942 id: bjp-26505 author: Setorki, Mahbubeh title: Effect of hydro-alcoholic extract of Ziziphus spina-christi against scopolamine-induced anxiety in rats date: 2016 words: 3847 flesch: 62 summary: The anxiolytic activity observed in this study may be related to anti-oxidant effects of extract. Hepatoprotective activity and anti-oxidant effects of El Nabka (Zizyphus spina-christi) fruits on rats hepatotoxicity induced by carbon tetrachloride. keywords: activity; anti; arms; christi; extract; rats; scopolamine; spina; time cache: bjp-26505.pdf plain text: bjp-26505.txt item: #480 of 942 id: bjp-26512 author: Cui, Yan; Ren, Hui; Li, Hao-Chang; Wang, Quan-Shi title: Artemisinic acid exhibits antitumor activity in MCF-7 breast cancer cells through the inhibition of angiogenesis, VEGF, m-TOR and AKT signalling pathways date: 2016 words: 3524 flesch: 55 summary: Artemisinic acid decreased 110 100 90 80 70 60 50 40 30 20 10 0 0 (Control) 5 10 25 50 100 150 % o f c el l d ea th Concentration of artemisinic acid (µM) A B Figure 1: A) Cytotoxic effect of artemisinic acid in human breast cancer cells (MCF-7). keywords: acid; akt; angiogenesis; artemisinic; assay; cancer; cells; pathways; tumor; vegf cache: bjp-26512.pdf plain text: bjp-26512.txt item: #481 of 942 id: bjp-26516 author: Saleem, Hammad; Ahmad, Irshad; Gill, M. Shoaib Ali title: Evaluation of lipoxygenase inhibition of Jatropha gossypifolia, a medicinal plant from Pakistan date: 2016 words: 840 flesch: 48 summary: Evaluation of lipoxygenase inhibition of Jatropha gossypifolia, a medicinal plant from Pakistan. Evaluation of lipoxygenase inhibition of Jatropha gossypifolia, a medicinal plant from Pakistan Sir, Inflammation is a common process by which the destruction of cells leading to various unrelated disorders like, cancer, diabetes, Alzheimer’s disease, Parkinson’s disease, heart diseases, stroke, arthritis, multiple sclerosis, etc can be precede. keywords: gossypifolia; inhibition; lipoxygenase cache: bjp-26516.pdf plain text: bjp-26516.txt item: #482 of 942 id: bjp-26517 author: Aslam, Muhammad title: Tail suspension test to evaluate the antidepressant activity of experimental drugs date: 2016 words: 1420 flesch: 62 summary: MATERIALS AND EQUIPMENT Suspension bar: In tail suspension test the mice are suspended by their tails. Tail suspension test, like the forced swimming test, is a test best approved for the assessment of antidepressant-like effects of medications, additionally used to assess the impacts of ecological, neurobiological, and hereditary controls (Crowley et al., 2005; Lad et al., 2007). keywords: suspension; tail; tape; test cache: bjp-26517.pdf plain text: bjp-26517.txt item: #483 of 942 id: bjp-26592 author: Zhuang, Hong-Mei; Hu, Xiao; Hong, Shu-Rong; Zhou, Ping-Ping; Zhang, Yu; Li, Ling title: 18alpha-Glycyrrhetinic acid inhibits the viability of HR5-CL11 cervical carcinoma cells through induction of apoptosis and DNA damage date: 2016 words: 3182 flesch: 59 summary: In the present study, the effect of 18α-glycyrrhetinic acid on cervical cancer cells along with the mechanism was investigated. It was observed that treatment of cervical cancer cells with 18α-glycyrrhetinic acid inhibited cell viability, induced DNA damage and apoptosis. keywords: 18α; acid; apoptosis; cancer; cells; cl11; dna; hours; hr5; treatment cache: bjp-26592.pdf plain text: bjp-26592.txt item: #484 of 942 id: bjp-26611 author: Qaralleh, Haitham title: Chemical and bioactive diversities of marine sponge Neopetrosia date: 2016 words: 9384 flesch: 57 summary: Sorek et al., 2007 26 Neopetrosiamine A Neopetrosia proxima Wei et al., 2010 27 Xestoproxamine A N. proxima Morinaka and Molinski, 2011 28 Xestoproxamine B N. proxima Morinaka and Molinski, 2011 29 Xestoproxamine C N. proxima Morinaka and Molinski, 2011 Pyridoacridine alkaloids 30 1-Hydroxydeoxy- amphimedine N. carbonaria Wei et al., 2010 31 3-Hydroxydeoxy- amphimedine N. carbonaria Wei et al., 2010 32 Debromopetrosamine N. carbonaria Wei et al., 2010 Bangladesh J Pharmacol 2016; 11: 433-452 437 Table II Chemical constituent of the Neopetrosia genus (Cont.) No. Compound class and name Source Reference 33 Amphimedine N. carbonaria Wei et al., 2010 34 Neoamphimedine N. carbonaria Wei et al., 2010 35 Deoxyamphimedine N. carbonaria Wei et al., 2010 Others alkaloids 36 Motuporamines A N. exigua (Xestospongia exigua) keywords: activity; alkaloids; anti; carbonaria; ch3 ch3; ch3 o; et al; exigua; genus; h h; marine; n o; n. exigua; neopetrosia; o h; o o; similis; species; sponge; vanilla; williams; xestospongia; xestospongia exigua cache: bjp-26611.pdf plain text: bjp-26611.txt item: #485 of 942 id: bjp-26620 author: Sun, Jun-Xia; Yan, Yan; Xia, Jian-Hong; Zhou, Li-Qing title: Bryostatin I inhibits growth of breast cancer cells through the inhibition of synuclein-A expression date: 2016 words: 3609 flesch: 54 summary: H3922 breast cancer cells that were treated with various concentrations of bryostatin I for 48 hours. Results Bryostatin I inhibits expression of synuclein-A Bryostatin I treatment of H3922 breast cancer cells led to the inhibition of synuclein-A expression in a concentration dependent manner. keywords: breast; bryostatin; cancer; cells; concentration; expression; h3922; synuclein; treatment cache: bjp-26620.pdf plain text: bjp-26620.txt item: #486 of 942 id: bjp-26682 author: Gupta, Sumeet; Kashyap, Priyanaka; Asad, Mohammed; Chattopadhyaya, Ipshita; Dahiya, Randhir title: Antidepressant activity of Nyctanthes arbor-tristis in mice date: 2016 words: 7010 flesch: 54 summary: Mice were divided into 11 different groups (6 mice each) and treated as follows: Group I: Vehicle-treated control group received 2% carboxymethyl cellulose; Group II: Received fluoxetine hydrochloride (20 mg/ kg); Group III, IV and V: Received petroleum ether extract (100, 200 and 400 mg/kg) of N. arbor-tristis; Group VI, VII and VIII: Received hydroethanol extract (100, 200 and 400 mg/kg) of N. arbor-tristis; Group IX, X and XI: Received chloroform extract (100, 200 and 400 mg/kg) of N. arbor-tristis. Group III, IV and V: Received fluoxetine hydro- chloride (10 mg/kg) with petroleum ether extract (100, 200 and 400 mg/kg) of N. arbor-tristis; Group VI, VII and VIII: Received fluoxetine hydrochloride (10 mg/kg) with hydroethanol extract (100, 200 and 400 mg/kg) of N. arbor-tristis; Group IX, X and XI): Received fluoxetine hydrochloride (10 mg/kg) with chloroform extract (100, 200 and 400 mg/kg) of N. arbor-tristis. keywords: acid; activity; arbor; chloroform; day; effect; extract; fluoxetine; group; hydroethanol; mice; nyctanthes; swimming; test; tristis cache: bjp-26682.pdf plain text: bjp-26682.txt item: #487 of 942 id: bjp-26689 author: Zheng, Wei; Junping, Zhang; Aihua, Zhang; Junming, Fan; Yanchun, Wang; Yanqing, Liu title: Anti-tumor effect of Huayu Jiedu formula on SGC-7901 cancer cell date: 2016 words: 4822 flesch: 62 summary: 10.3329/bjp.v11iS1.26689 Cite this article: Zheng W, Junping Z, Aihua Z, Junming F, Yanchun W, Yanqing L. Anti-tumor effect of Huayu Jiedu formula on SGC-7901 cancer cell. Among these targets are many signal- transduction proteins (e.g. kinases) that regulate malignant processes in cancer cells (Hidalgo and Rowinsky, 2000). keywords: activity; akt; cancer; cells; ctx; hours; hyjd; kinase; pdk1; phosphorylation; protein; sgc-7901; tumor cache: bjp-26689.pdf plain text: bjp-26689.txt item: #488 of 942 id: bjp-26692 author: Bai, Lin; Wang, Hui; Zhang, Luo-Ying; Wang, Ai-Hua; Bai, Jie title: Ludartin treatment exhibits promising inhibitory effect on the epithelial ovarian cancer growth and metastasis date: 2016 words: 3362 flesch: 57 summary: Thus, ludartin treatment inhibits the proliferation, invasion and migration of ovarian cancer cells through down-regulation of pFAK and MMPs, therefore can be used for the treatment of ovarian cancer. Discussion The present study shows that ludartin treatment inhibi- ted the proliferation and reduced adhesive, invasive and migration potential of ovarian cancer cells through inhibition of p-FAK and MMP-9 expression. keywords: cancer; cells; control; hours; ludartin; ovcar5; rats; treatment cache: bjp-26692.pdf plain text: bjp-26692.txt item: #489 of 942 id: bjp-26705 author: Zhao, Li-Na; Chen, Li-Bo; Hao, Xiu-Hua; Hu, Zhang; Zhang, Jing; Zhang, Chun-Hai title: Floroquinone induces apoptosis and inhibits carcinoma growth in mouse tumor xenograft model of anaplastic thyroid cancer date: 2016 words: 3644 flesch: 60 summary: The present study demonstrates the effect of floroquinone on the growth of thyroid cancer cells both in vitro and in vivo. Conclusion Floroquinone exhibits promising inhibitory effect on the growth and metastasis of thyroid cancer cells. keywords: apoptosis; cancer; cells; expression; floroquinone; growth; hothc; thyroid; treatment; tumor cache: bjp-26705.pdf plain text: bjp-26705.txt item: #490 of 942 id: bjp-26707 author: Mei, Tang; Cao, Liu; Zi, Liang; Mingfu, Gong; Die, Hu title: Studies on separation and properties of lumbrokinase in Pheretima praepinguis date: 2016 words: 2229 flesch: 57 summary: Lumbrokinase activity was relatively stable Bangladesh J Pharmacol 2016; 11: S106-S109 S107 Figure 1: Lumbrokinase activity detection with casein plate method and high activity in the alkaline environment (pH 7-9), Lumbrokinase activity retention rate maintain 75% when pH increased to 11. Effect of pH and temperature on lumbrokinase activity was studied. keywords: activity; enzyme; lumbrokinase; solution; temperature cache: bjp-26707.pdf plain text: bjp-26707.txt item: #491 of 942 id: bjp-26728 author: Cao, Xian-De; Zheng, Hui-Min title: Zerumbone inhibits prostate cancer cell viability and induces cell death by non-apoptotic pathway date: 2016 words: 3032 flesch: 53 summary: Bangladesh Journal of Pharmacology Research Article BJP Zerumbone inhibits prostate cancer Zerumbone inhibits prostate cancer Zerumbone inhibits prostate cancer cell viability and induces cell death cell viability and induces cell death cell viability and induces cell death by nonby nonby non---apoptotic pathwayapoptotic pathwayapoptotic pathway Introduction Prostate carcinoma at present is one among the common causes of cancer related deaths in males throughout the world. Furthermore, zerumbone treatment has been shown to induce expression of tumor necrosis factor-α, enhance the secretion of oxygen free radicals in cancer cells (Murakami et al., 2002; Sung et al., 2008; Takada et al., 2005). keywords: cancer; cells; death; du-145; prostate; treatment; zerumbone cache: bjp-26728.pdf plain text: bjp-26728.txt item: #492 of 942 id: bjp-26729 author: Zhang, Fu-Hua; Yan, Yu-Ling; Wang, Ying; Liu, Zhen title: Lactucin induces potent anti-cancer effects in HL-60 human leukemia cancer cells by inducing apoptosis and sub-G1 cell cycle arrest date: 2016 words: 3116 flesch: 51 summary: The key feature of lactucin treated cells was the advent of vacuoles in the cytoplasm and their number which increased with increasing lactucin dose. Phase contrast microscopy for morphological evaluation (Video Clips 1 2 3 4 5 6 7 8 9 ) HL-60 human leukemia cancer cells were trypsinized followed by centrifugation at 12,000 rpm. keywords: apoptosis; cancer; cells; effects; human; lactucin; leukemia cache: bjp-26729.pdf plain text: bjp-26729.txt item: #493 of 942 id: bjp-26759 author: Gunasekaran, Vinoth Prasanna; Nishi, Kumari; Ravikumar, Vilwanathan; Mathan, Ganeshan title: Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target date: 2016 words: 20060 flesch: 59 summary: The overexpression of YB-1 in cancer cells is an important biomarker for clinical outcome of the cancer patients and to an extrapolation it is assumed that the appearance of YB-1 in cell nuclei or its increased content in adjoining tissues of tumor is an indication of the aggressiveness and advanced stages as suggested by many cancer studies (Ha et al., 2015). Augmented focal adhesion kinase expression has been stated in many tumors like colon, ovary and breast cancers and its inhibition sensitizes cancer cells to chemotherapy (Owens et al., 1995). keywords: activation; akt; bangladesh; binding; biol; box; brain; breast; breast cancer; cancer; cancer cells; carcinoma; cell; dna; domain; e t; et al; expression; factor; gene; growth; human; inhibition; kinase; lines; metastasis; nuclear; overexpression; p53; patients; pharmacol; phosphorylation; progression; prostate; protein; receptor; resistance; role; stat3; studies; study; survival; target; tumor; wang; yb-1 cache: bjp-26759.pdf plain text: bjp-26759.txt item: #494 of 942 id: bjp-26767 author: Xu, Xiao-Yan; Wang, Hui-Rui; Guo, Shu-Li; Li, Bo; Lv, Tao title: 5-Methoxyhydnocarpin shows selective anti-cancer effects and induces apoptosis in THP-1 human leukemia cancer cells via mitochondrial disruption, suppression of cell migration and invasion and cell cycle arrest date: 2016 words: 4151 flesch: 55 summary: Cancer cells are reported to escape the apoptotic cell suicide through the mediation of various genetic and epigenetic alterations. MTT cell proliferation assay Human leukemia cancer cells (THP-1) were seeded at a density of 2 x 105 cells per well in a 96-well culture plates. keywords: assay; cancer; cells; effects; human; leukemia; methoxyhydnocarpin; mhc; migration; thp-1 cache: bjp-26767.pdf plain text: bjp-26767.txt item: #495 of 942 id: bjp-26771 author: Chander, M. Punnam; Vijayachari, Paluru title: In vitro antimicrobial and anti-oxidant potentials of selected medicinal plants used by the indigenous tribes of Andaman and Nicobar Islands, India date: 2016 words: 1445 flesch: 56 summary: I Phytochemical analysis of the methanol extracts of selected ethnomedicinal plants Scientific name Alkaloids Flavonoids Triterpenoids Sterols Tannins Saponins Abutilon indicum (L.) Sweet Present Present Present Present Present Present Ageratum conyzoides L. Present Present Present Present Absent Absent Annona squamosa L. Present Present Present Present Present Absent Boesenbergia rotunda (L.) Mansf. Present Present Present Present Present Present The antimicrobial activities of the investigated extracts against human pathogens used by agar well diffusion method were shown in Table II. keywords: activity; l. present; present cache: bjp-26771.pdf plain text: bjp-26771.txt item: #496 of 942 id: bjp-26776 author: Eom, Hee Jeong; Park, Yong Joo; Kang, Hee Rae; Kim, Ha Ryong; Bang, In Jae; Park, Hyun Bong; Chung, Kyu Hyuck; Kim, Ki Hyun title: Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity date: 2016 words: 3096 flesch: 56 summary: Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity Hee Jeong Eom1, Yong Joo Park1, Hee Rae Kang1, Ha Ryong Kim1, In Jae Bang1, Hyun Bong Park2, Kyu Hyuck Chung1 and Ki Hyun Kim1 1School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea; 2Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States. http://www.bioxbio.com/if/html/BANGL-J-PHARMACOL.html report the inhibitory effect of S. palustre extract and nine compounds (1-9) on aromatase activity using recombi- nant human CYP19 (Figure 1). S. palustre extract could inhibit aromatase activity, with compounds 1, 6, and 7 identified as the active components. keywords: activity; aromatase; compounds; extract; hplc; inhibition; palustre cache: bjp-26776.pdf plain text: bjp-26776.txt item: #497 of 942 id: bjp-26793 author: Xu, Yong Qian; Zhang, Jian Hai; Yang, Xing Sheng title: Corosolic acid induces potent anti-cancer effects in CaSki cervical cancer cells through the induction of apoptosis, cell cycle arrest and PI3K/Akt signalling pathway date: 2016 words: 3729 flesch: 52 summary: Cytotoxicity was expressed as the concentration of corosolic acid inhibiting cell growth by 50% (IC50 value). Several natural products are known to induce apoptosis in a wide variety of cancer cells. keywords: acid; akt; anti; apoptosis; cancer; caski; cells; corosolic; hours; pi3k cache: bjp-26793.pdf plain text: bjp-26793.txt item: #498 of 942 id: bjp-26799 author: Hong, Quan Xiao; Hong, Ma; Ying, Li; Cai, Wu; Hua, Chen Xiu title: Acupuncture compares with Western medicine for climacteric depression date: 2016 words: 5126 flesch: 58 summary: In view of this, we analyzed studies on simple acupunc- ture compared to Western medicine for climacteric depression according to Cochrane systematic review of the research method to investigate the efficacy and safety of acupuncture treatment of this disease. Therefore, according to the evaluation results suggest that the efficacy of acupuncture treatment of climacteric depression is likely better than Western medicine. keywords: acupuncture; bias; depression; group; hamd; score; trials; zhou cache: bjp-26799.pdf plain text: bjp-26799.txt item: #499 of 942 id: bjp-26832 author: Wu, Qiang; Wang, Pu; Wang, Changhong; Liu, Xiangrong; Zhang, Xue title: Effect of sanhuanghuoxue decoction on the treatment of chronic renal failure date: 2016 words: 3407 flesch: 50 summary: Apparently, sanhuanghuoxue decoction treatment caused a bigger drop than coated aldehyde oxystarch- treated did, suggesting that sanhuanghuoxue decoction is more effective in improving the blood viscosity of rats with chronic renal failure. Animal models Rats were randomly divided into normal/control group, prevention group, disease group, sanhuang- huoxue decoction-treated group and coated aldehyde oxystarch-treated group. keywords: aldehyde; blood; decoction; group; oxystarch; rats; sanhuanghuoxue cache: bjp-26832.pdf plain text: bjp-26832.txt item: #500 of 942 id: bjp-26835 author: Mumtaz, Amara; Saeed, Aamer; Fatima, Nighat; Dawood, Muhammad; Rafique, Hummera; Iqbal, Jamshed title: Imidazole and its derivatives as potential candidates for drug development date: 2016 words: 5563 flesch: 56 summary: Sharma D, Narasimhan B, Kumar P, Judge V, Narang R, De Clercq E, Balzarini J. Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. A series of N-(4-(4-chloro-1H-imidazol-1-yl)-3-metho- xyphenyl)amide (22) and N-(4-(4-chloro-1H-imidazol-1- yl)-3-methoxyphenyl) sulfonamide (23) derivatives showed potent antitubercular activities activity against M. tuberculosis H37Rv, M. smegmatis, M. fortuitum and MDR-TB strains (Ranjith et al., 2014). keywords: activities; activity; anti; cancer; cell; chem; compounds; derivatives; drugs; et al; eur; hepatitis; imidazole; j med; lines; med; med chem; synthesis; treatment; virus cache: bjp-26835.pdf plain text: bjp-26835.txt item: #501 of 942 id: bjp-26844 author: Guangyu, Xu; Jiamu, Niu; Guangxin, Yuan; Yu, Bai; Hongyu, Li; Yu, Sheng; Zitong, Li title: Determination of eight lignans in Schisandra chinensis and Schisandra sphenanthera date: 2016 words: 3562 flesch: 52 summary: The established content determination method was simple, sensitive, accurate and stable, and can be used to control the quality of S. chinensis and S. sphenanthera. In this study, a simple, rapid and sensitive HPLC method has been developed for the simultaneous quantitative analysis of eight lignans in S. chinensis and S. sphenanthera, and the content of eight active lignan components in 15 batch of S. chinensis and 5 batch of S. Sphenanthera were determined in this method. keywords: chinensis; lignans; method; schisandrin; sphenanthera cache: bjp-26844.pdf plain text: bjp-26844.txt item: #502 of 942 id: bjp-26845 author: He, Chunting; Chen, Qingfen; Zhu, Longkun title: A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion date: 2016 words: 3288 flesch: 56 summary: After 7 days of GFP-tagged C. neoformans H99 (A, B) intratracheal inoculation, H99 could be found in regions of M1-M2 and CPu (C, Bregma 0.74), and in regions of SLu, CA1, RSA-V2MM-V2ML-V1-V2L, LMol-Mol, and DLG-LPLR-LPMR (D, Bregma -2.18 mm). C. neoformans are commonly acquired by inhalation (Day et al., 2013; Jarvis et al., 2009). keywords: brain; cns; cryptococcus; gfp; h99; neoformans; regions cache: bjp-26845.pdf plain text: bjp-26845.txt item: #503 of 942 id: bjp-26851 author: Tang, Binhua; Zhu, Weiliang; Wu, Changping title: Cross-cell DNA methylation annotation and analysis for pan-cancer study date: 2016 words: 3227 flesch: 45 summary: In coming days, further annotation and analysis results concerning pan-cancer analysis will be updated into the knowledgebase, especially we seek to provide an interactive environment for biomedical researchers to fetch and utilize this knowledgebase. Cross-cell DNA methylation annotation and analysis for pan-cancer study Binhua Tang1,2,3, Weiliang Zhu4 and Changping Wu4 1Epigenetics and Function Group, College of the Internet of Things, Hohai University, Jiangsu 213 022, China; 2School of Public Health, Shanghai Jiao Tong University, Shanghai 200 225, China; 3CBMI, Harvard Medical School, Boston, MA 02 115, USA; 4The Third Affiliated Hospital, Soochow University, Jiangsu 213 003, China. http://www.bioxbio.com/if/html/BANGL-J-PHARMACOL.html http://www.asiajol.info/index.php/record/view/50672 Structure and Purpose of DMAK DMAK contains three levels of curated information across multiple cell types from ENCODE Consortium portal (de Souza, 2012; Pennisi, 2012; Tang and Wang, 2015; The ENCODE Project Consortium, 2012). keywords: analysis; annotation; cancer; cell; dmrs; dna; figure; genes; hypo; information; methylation; reference; results cache: bjp-26851.pdf plain text: bjp-26851.txt item: #504 of 942 id: bjp-26915 author: Rabiei, Zahra; Lorigooini, Zahra; Kopaei, Mahmoud Rafieian title: Effects of hydroalcoholic extract of Borago officinalis on naloxone-precipitated withdrawal syndrome in morphine-dependent mice date: 2016 words: 3494 flesch: 48 summary: Figure 1 illustrates the effect of B. officinalis extract, as co -treatment and post-treatment, on the frequency of naloxone-induced jumping in the morphine-dependent mice. c c c c Figure 2: The effect of Borago officinalis extract injection, as post-treatment and co-treatment, on the frequency of naloxone-induced blinking, rearing and ptosis in morphine-dependent mice; ap<0.05; bp=0.01-0.05; cp<0.01 Figure 1: The effect of Borago officinalis extract injection, as post-treatment and co-treatment, on the frequency of naloxone-induced jumping and paw tremor in morphine-dependent mice; ap<0.01 826 Bangladesh J Pharmacol 2016; 11: 824-829 -treatment with B. officinalis extract caused a significant decrease in the frequency of ptosis compared to the morphine-dependent group (p<0.01). keywords: extract; frequency; group; morphine; naloxone; officinalis; treatment; withdrawal cache: bjp-26915.pdf plain text: bjp-26915.txt item: #505 of 942 id: bjp-26919 author: Jing, Shi Jing; Bo, Shi; Mingsan, Miao; Qingya, Li title: Effect of Ligustrum lucidum polysaccharide on immunity of immunosuppressed mice date: 2016 words: 2717 flesch: 47 summary: Therefore, L. lucidum polysaccharide could markedly improve the immune functions of hydrocortisone-induced immunosuppressed model mouse. The experiment, concerning effects of L. lucidum polysaccharide on phagocytic function of immunosuppressed mouse peritoneal macrophage may reflect the effect on non-specific immunological competence of immunosuppressed model mouse. keywords: dose; group; lucidum; model; mouse; polysaccharide cache: bjp-26919.pdf plain text: bjp-26919.txt item: #506 of 942 id: bjp-26948 author: Shan, Cao; Shuo, Tian; Ming, Bai; Shaoyan, Liu; Jiaojiao, Jia; Mingsan, Miao title: Effects of Curculigo orchioides total glucosides in mouse perimenopause model of related organization and organs morphology date: 2016 words: 4095 flesch: 51 summary: The results indicate that compared with the model group, soybean isoflavone soft capsule, gengnianan capsule and big, medium, small dose of C. rhizome total glycoside group could significant- ly improved the pathological changes in mouse uterus, hypothalamic, thickening of the thymic cortex and significantly increased the number of lymphocytes in the cortex, increased the volume of splenic nodule (p<0.01), in which the effect of large dose of C. orchioides total glycosides group was the best. The drug significantly improved the uterine pathological lesions (p<0.01), in which the effect of large dose of Curculigo rhizome total glycoside group was the best. keywords: chinese; curculigo; curculigo rhizome; dose; glycoside; group; model; perimenopausal; rhizome; syndrome; total cache: bjp-26948.pdf plain text: bjp-26948.txt item: #507 of 942 id: bjp-26957 author: Bajpai, Vivek K.; Rather, Irfan A.; Kim, Kangmin title: Isolation of mouse internal organs for molecular and histopathological studies date: 2016 words: 1729 flesch: 51 summary: There is a growing trend of using animal tissues for drug discovery research (Deng et al., 2016). Petri dishes  Freezer (-80˚C) for preservation of animal tissue slides until further analysis PREPARATION OF REAGENTS Phosphate buffer solution 1x (pH 7.4) NaCl 8 g KCl 0.2 g Na2HPO4 1.44 g KH2PO4 0.24 g Make volume 1 liter and mix well and autoclave. keywords: animals; diseases; isolation; organs; tissue cache: bjp-26957.pdf plain text: bjp-26957.txt item: #508 of 942 id: bjp-26961 author: Krishnaveni, Marimuthu; Suresh, Kathiresan; Arunkumar, Ramu title: Antiproliferative and apoptotic effects of quinine in human Hep-2 laryngeal cancer and KB oral cancer cell date: 2016 words: 4233 flesch: 56 summary: Zhang H, Li X, Zhang Y, Luan X. Luteolin induces apoptosis by activating Fas signaling pathway at the receptor level in laryngeal squamous cell line Hep-2 cells. Mitochondrial membrane potential Changes of mitochondrial membrane potential in Hep-2 and KB cells were observed when treated with quinine (Figures 2). keywords: anti; apoptosis; cancer; cells; expression; p53; quinine cache: bjp-26961.pdf plain text: bjp-26961.txt item: #509 of 942 id: bjp-27000 author: Akacha, Maroua; Lahbib, Karima; Daami-Remadi, Mejda; Boughanmi, Néziha Ghanem title: Antibacterial, antifungal and anti-inflammatory activities of Melia azedarach ethanolic leaf extract date: 2016 words: 5669 flesch: 46 summary: Accepted: 28 April 2016 Available Online: 5 June 2016 DOI: 10.3329/bjp.v11i3.27000 Cite this article: Akacha M, Lahbib K, Remadi MD, Ghanem N. Antibacterial, antifungal and anti-inflammatory activities of Melia azedarach ethanolic leaves ex- tract. × 100 Anti-inflammatory activity (Video Clip) Anti-inflammatory activity of M. azedarach ethanolic leaves extract and indomethacin, as standard drug, was determined by carrageenan-induced hind paw edema (Winter et al., 1962). keywords: acid; activities; activity; anti; antibacterial; antifungal; azedarach; bangladesh; biolog; effects; et al; ethanolic; extract; leaves; melia; oxysporum cache: bjp-27000.pdf plain text: bjp-27000.txt item: #510 of 942 id: bjp-27010 author: Huo, Jiang Yan; Shen, Hong Chao; Wang, Shu Mei; Chen, Zhan Ke; Liang, Sheng Wang title: Anti-aging activity of Radix polygoni multiflori preparata in aging mice model induced by D-galactose by bioassay method date: 2016 words: 5091 flesch: 51 summary: Anti-aging activity of Radix polygoni multiflori preparata in aging mice model induced by D- galactose by bioassay method. Anti-aging activity of Radix polygoni multiflori preparata in aging mice model induced by D-galactose by bioassay method Jiang Yan Huo1, Hong Chao Shen1, Shu Mei Wang1, Zhan Ke Chen2 and Sheng Wang keywords: activity; aging; chinese; content; control; emodin; group; method; mice; multiflori; polygoni; radix; solution cache: bjp-27010.pdf plain text: bjp-27010.txt item: #511 of 942 id: bjp-27014 author: Kabiri, Najmeh; Setorki, Mahbubeh title: Protective effect of Kombucha tea on brain damage induced by transient cerebral ischemia and reperfusion in rat date: 2016 words: 4358 flesch: 51 summary: Ischemic group 1 120 100 80 60 40 20 0 B B B p er m ea bi lit y Ischemic group 2 Ischemic group 3 Sham group BBB right hemisphere BBB left hemisphere Figure 2: BBB permeability of the left and right hemispheres in the ischemic group1, received no Kombucha solution; ischemia group 2, intraperitoneally injected with 5 mg/kg Kombucha solution; ischemia group 3, intraperitoneally injected with 15 mg/kg Kombucha solution; and the Sham group, with no drug administration. Ischemic group 1 100 80 60 40 20 0 B ra in w at er c on te nt Ischemic group 2 Ischemic group 3 Sham group BWC r BWC l Figure 3: BWC of the right and left hemispheres of the ischemic group1, received no Kombucha solution; ischemia group 2, intra- peritoneally injected with 5 mg/kg Kombucha solution; ischemia group 3, intraperitoneally injected with 15 mg/kg Kombucha solution; and the Sham group, with no drug administration. keywords: anti; brain; group; ischemia; kombucha; kombucha solution; sham; solution; tea cache: bjp-27014.pdf plain text: bjp-27014.txt item: #512 of 942 id: bjp-27054 author: Alamgeer, .; Asif, Hira; Rasool, Shahid title: Antithrombotic potential of Berberis calliobotrys extract date: 2016 words: 5354 flesch: 59 summary: ap<0.001, bp<0.01 and cp<0.05 Table I Effect of different extracts on in vitro clotting, prothrombin and activated partial thromboplastin time Parameters Effect of crude extract Human blood Rabbit blood Control 5% 10% 20% Control 5% 10% 20% CT (min) 8.8 ± 0.4 13.6 ± 1.1a 18.4 ± 0.6a 22.2 ± 1.2a 9 ± 0.5 13.4 ± 0.9a 16 ± 0.6a 20.4 ± 0.5a PT (s) 13 ± 1.2 47.6 ± 1.2a 107.3 ± 3.7a 170 ± 5.7a 11.3 ± 0.9 44.0 ± 2.1 a 83.7 ± 3.4a 204.6 ± 1.4a APTT (s) 25.3 ± 0.3 49.6 ± 0.3a 107.6 ± 7.8a 183.3 ± 3.3a 28 ± 1.5 61.6 ± 1.6a 121.6 ± 1.6a 237.6 ± 1.4a Parameters Effect of butanolic fraction Human blood Rabbit blood Control 2.5% 5% 10% Control 2.5% 5% 10% CT (min) 8 ± 0.0 10.3 ± 0.3c 14 ± 0.4a 44 ± 1.4a 6.8 ± 0.5 9.8 ± 0.3b 12.8 ± 0.5a 40.5 ± 0.5a PT (s) 13 ± 1.15 49.6 ± 1.3a 72.6 ± 1.5a 127.6 ± 1.5a 11.3 ± 0.9 49 ± 2.1a 73.6 ± 0.7a 138.3 ± 2.7a APTT (s) 25.3 ± 0.3 44.6 ± Statstical analysis Data was presented as mean ± SEM and statistical analysis were performed by analysis of variance (ANOVA) by using Graph Padprism version 5. keywords: blood; butanolic; calliobotrys; clot; effect; extract; fraction; platelet; time cache: bjp-27054.pdf plain text: bjp-27054.txt item: #513 of 942 id: bjp-27103 author: Damjanovic, Ana Damjanovic; Zdunic, Gordana; Savikin, Katarina; Mandic, Boris; Jadranin, Milka; Matic, Ivana Z.; Stanojkovic, Tatjana P. title: Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis date: 2016 words: 5363 flesch: 51 summary: These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. The formation of new blood vessels is very important for the metastatic spread of cancer tissue and the new vascular network ensures supplying of cancer cells with oxygen and nutrients. keywords: anti; aquifolium; berberine; cancer; cells; effects; et al; ethanol; extracts; hela; hours; mahonia; water cache: bjp-27103.pdf plain text: bjp-27103.txt item: #514 of 942 id: bjp-27131 author: Aslam, Naveed; Janbaz, Khalid Hussain; Jabeen, Qaiser title: Hypotensive and diuretic activities of aqueous-ethanol extract of Asphodelus tenuifolius date: 2016 words: 5012 flesch: 51 summary: Diuretic effect of the extract involves loop diuretic or thiazide diuretic like actions, while carbonic anhydrase inhibitory and potassium sparing activities were not likely to be present. Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. keywords: at.cr; blood; ca2; contractions; diuretic; effects; extract; plant; pressure; tenuifolius cache: bjp-27131.pdf plain text: bjp-27131.txt item: #515 of 942 id: bjp-27170 author: Bajpai, Vivek K.; Majumder, Rajib; Rather, Irfan A.; Kim, Kangmin title: Extraction, isolation and purification of exopolysaccharide from lactic acid bacteria using ethanol precipitation method date: 2016 words: 1748 flesch: 41 summary: Degradation of exopolysaccharide production on prolonged incubation has been reported previously for other lactic acid bacteria strains (Degeest et al., 2001). 2016; 11: 573-576 VISUAL EXPERIMENT Extraction, isolation and purification of exopolysaccharide from lactic acid bacteria using ethanol precipitation method Vivek K. Bajpai1, Rajib Majumder1, Irfan A. Rather1 and Kangmin Kim2 1 Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712- 749, South Korea; 2 Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, 79 Gobong-ro, Iksan-si-570-752, Joellabuk-do (Jeonbuk), South Korea. keywords: acid; bacteria; exopolysaccharides; min; precipitate cache: bjp-27170.pdf plain text: bjp-27170.txt item: #516 of 942 id: bjp-27200 author: Li, Ying; Han, Na; Chen, Zhuo; Li, Xing title: Systematic review and meta-analysis of shenqi fuzheng and chemotherapy combination in the treatment of breast cancer date: 2016 words: 5629 flesch: 59 summary: Table I Baseline characteristics of the eligible trials Reference Randomi- zation Allocation concealment Form of double-blind Loss of imitation and exit cases ITT analysis Baseline Cochrane score Xiao et al., 2005 Mention Unclear Unclear Unclear Unclear Yes C Chen et al., 2007 Mention Unclear Unclear Unclear Unclear Yes C Xu et al., 2010 Mention Unclear Unclear Unclear Unclear Yes C Chen et al., 2010 Mention Unclear Unclear Unclear Unclear Yes C Yuan et al., 2008 Random number Unclear Unclear Unclear Unclear Pu Z, Yuan X, Zhang X, Chen Q, Xie H. Meta-analysis on the association between CYP2D6*10 gene polymorphism and disease free survival of breast cancer patients receiving tamoxifen treatment in Asia. keywords: breast; breast cancer; cancer; chemotherapy; days; et al; fuzheng; injection; patients; shenqi; treatment cache: bjp-27200.pdf plain text: bjp-27200.txt item: #517 of 942 id: bjp-27318 author: Rabiei, Zahra; Gholami, Mostafa; Rafieian-Kopaei, Mahmoud title: Antidepressant effects of Mentha pulegium in mice date: 2016 words: 2605 flesch: 48 summary: Furthermore, the findings on M. pulegium effect was not dose- dependent in treating the depression symptoms of the BALB/c mice because no significant difference was derived in the immobility duration in the FST among the groups treated with different doses of M. pulegium. Materials and Methods In this study, 42 BALB/c mice were used and assigned to six groups of seven each as follows: Intraperitoneally injected with 1 mL/kg body weight normal saline (control); administered with intraperitoneal reserpine (5 mg/kg BW); administered with reserpine 18 hours before administration of M. pulegium essential oil; intraperitoneally injected with M. pulegium essential oil (50, 75, and 100 mg/kg BW); and administered with reserpine (5 mg/kg BW) 18 hours before intraperitoneal administration of 20 mg/kg BW fluoxetine. keywords: antidepressant; duration; effects; fst; immobility; mice; oil; pulegium cache: bjp-27318.pdf plain text: bjp-27318.txt item: #518 of 942 id: bjp-27340 author: Shah, Abdul Jabbar; Bukhari, Ishfaq Ali; Gilani, Anwarul Hassan title: Mentha longifolia lowers blood pressure in anesthetized rats through multiple pathways date: 2016 words: 5437 flesch: 52 summary: In guinea pig atrial strips, crude extract and chloroform fraction suppressed force and rate of contractions, similar to verapamil. Preparation of crude extract and fractionations Plant material was shade dried and coarsely grounded, soaked in 70% aqueous-methanol for three days and filtered through a filter paper (Shah et al., 2011; Shah and Gilani, 2011; Khan et al., 2013). keywords: atropine; blood; ca++; chloroform; contractions; effect; endothelium; extract; figure; fraction; pressure cache: bjp-27340.pdf plain text: bjp-27340.txt item: #519 of 942 id: bjp-27384 author: Liang, Quan; Fu, Qiang; Li, Wei; You, Jiacong; Zhao, Zhanchao title: Lapatinib, trastuzumab or the combination added to neoadjuvant chemotherapy for breast cancer date: 2016 words: 3680 flesch: 52 summary: Abstract The aim of this study was to compare the efficacy and safety of trastuzumab versus the combination of trastuzumab and lapatinib added to neo- adjuvant chemotherapy for HER2 positive breast cancer. Trastuzumab in breast cancer neoadjuvant therapy (Gianni et al., 2011) and adjuvant therapy (Viani et al., 2007) and metastasis of breast cancer (Harris et al., 2011) can make patients benefit from this has now been confirmed. keywords: breast; breast cancer; cancer; chemotherapy; her2; lapatinib; neoadjuvant; risk; study; trastuzumab cache: bjp-27384.pdf plain text: bjp-27384.txt item: #520 of 942 id: bjp-27404 author: Mesgari Abbasi, Mehran; Valizadeh, Hadi; Hamishehkar, Hamed; Bannazadeh Amirkhiz, Maryam; Zakeri-Milani, Parvin title: In vitro and in situ effects of atorvastatin and ezetimibe on P-glycoprotein expression and function date: 2016 words: 5911 flesch: 50 summary: It was shown that consistent elevation of serum ezetimibe concentrations could result from inhibition of P-gp and MRP2 by gemfibrozil, feno- fibrate and cyclosporine (Suchy et al., 2011). This study was performed to investigate the effects of atorvastatin and ezetimibe on the function and expression of P-gp. keywords: atorvastatin; caco-2; cells; concentrations; control; digoxin; drug; et al; expression; ezetimibe; verapamil cache: bjp-27404.pdf plain text: bjp-27404.txt item: #521 of 942 id: bjp-27476 author: Sawarkar, Hemant Arunrao; Kashyap, Pranita P.; Pandey, Ajit Kumar; Singh, Mukesh Kumar; Kaur, Chanchal Deep title: Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study date: 2016 words: 5146 flesch: 54 summary: Zone of inhibition and MIC values obtained for all the extracts suggest ethanolic extract of the herbs were more antimicrobial when compared to the aqueous extract. Cytotoxicity was evaluated by MTT assay on human gingival fibroblast and human dermal fibroblast cell lines for ethanolic extract of the herbs. keywords: activity; barleria; biofilm; chlorhexidine; extract; grandiflora; mic; prionitis; study cache: bjp-27476.pdf plain text: bjp-27476.txt item: #522 of 942 id: bjp-27517 author: Pan, Zheng; Wang, Shuan-Ke; Cheng, Xiao-Li; Tian, Xia-Wei; Wang, Jing title: Caryophyllene oxide exhibits anti-cancer effects in MG-63 human osteosarcoma cells via the inhibition of cell migration, generation of reactive oxygen species and induction of apoptosis date: 2016 words: 3254 flesch: 46 summary: The effect of caryophyllene oxide on the ROS generation in MG-63 human osteosarcoma cells was studied using flow cytometry using 2'-7'-dichloro- Figure 1: Cytotoxic effect of caryophyllene oxide in human osteosarcoma cells (MG-63) at different doses. Cell proliferation assay using MTT (Video Clip) MG-63 human osteosarcoma cells were seeded in a 96- well plates at 2 × 106 cells per well. keywords: apoptosis; bangladesh; cancer; caryophyllene; cells; mg-63; migration; osteosarcoma; oxide cache: bjp-27517.pdf plain text: bjp-27517.txt item: #523 of 942 id: bjp-27518 author: Zhang, Shuai; Jiang, Zong-Fei; Pan, Qiang; Song, Chun-Yu; Zhang, Wen-Hua title: Anti-cancer effect of naringenin chalcone is mediated via the induction of autophagy, apoptosis and activation of PI3K/Akt signalling pathway date: 2016 words: 3743 flesch: 53 summary: Arrows indicate autophagic vacuoles which were seen only in drug-treated cells Naringenin chalcone dose (µM) p-PI3K PI3K p-Akt Akt Actin 0 (control) 10 50 100 Figure 4: Naringenin chalcone targets PI3K/Akt signalling pathway in U87MG human glioblastoma cells. Abstract The aim of the current study was to investigate the in vitro and in vivo anti- tumor effects of naringenin chalcone in U87MG human glioblastoma cells and in xenograft mice model. keywords: akt; apoptosis; cells; chalcone; glioblastoma; human; naringenin; naringenin chalcone; pi3k; tumor; u87 cache: bjp-27518.pdf plain text: bjp-27518.txt item: #524 of 942 id: bjp-27539 author: Lin, Li; Cheng, Xiao-Ling; Li, Ming-Zhe; Wang, Tao; Dong, Min-Hai; Wang, Zhen-Yu; Liao, Min title: Antitumor effects of iridomyrmecin in HeLa cervical cancer cells are mediated via apoptosis induction, loss of mitochondrial membrane potential, cell cycle arrest and down-regulation of PI3K/Akt and up-regulation of lncRNA CCAT2 expression date: 2016 words: 3916 flesch: 52 summary: As shown in Figure 6, after normalization to GAPDH expression levels, the expression level of lncRNA CCAT2 in cervical cancer cells treated with iridomyrmecin was significantly higher than that in adjacent non-tumor tissues as well as cancer tissues without any drug treatment. Bangladesh Journal of Pharmacology Research Article Antitumor effects of iridomyrmecin in Antitumor effects of iridomyrmecin in Antitumor effects of iridomyrmecin in HeLa cervical cancer cells are mediat-HeLa cervical cancer cells are mediat-HeLa cervical cancer cells are mediat- ed via apoptosis induction, loss of mi-ed via apoptosis induction, loss of mi-ed via apoptosis induction, loss of mi- tochondrial membrane potential, cell tochondrial membrane potential, cell tochondrial membrane potential, cell cycle arrest and downcycle arrest and downcycle arrest and down---regulation of regulation of regulation of PI3K/Akt and upPI3K/Akt and upPI3K/Akt and up---regulation of lncRNA regulation of lncRNA regulation of lncRNA CCAT2 expressionCCAT2 expressionCCAT2 expression BJP Introduction China represents one of the few countries with a very high occurrence of cervical cancer and is accountable for more than 45% of all the new cases diagnosed globally. keywords: akt; apoptosis; cancer; cells; hela; human; iridomyrmecin; loss; pi3k; potential; regulation cache: bjp-27539.pdf plain text: bjp-27539.txt item: #525 of 942 id: bjp-2758 author: Parvin, Most. Nazma; Rahman, Mohammad S.; Islam, Mohammad S.; Rashid, Mohammad A. title: Chemical and biological investigations of Dillenia indica Linn. date: 2009 words: 2848 flesch: 57 summary: I LC50 data of different extracts D. indica using brine shrimp lethality bioassay Samples LC50 (mg/mL) Vincristine sulphate (standard) 0.8 ± 0.5 Crude methanolic extract 8.9 ± 0.6 n-Hexane soluble fraction of the meth- anolic extract 11.3 ± 0.3 Carbon tetrachloride soluble fraction of the methanolic extract 14.0 ± The crude methanol extract and its n-hexane, carbon tetrachloride and chloroform soluble fractions (500 μg/ disc) were screened against 13 test bacteria (Bacillus cereus, B. megaterium, B. subtilis, Staphylococcus aureus, Sarcina lutea, Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphi, S. typhi, Shigella boydii, S. dysenteriae, Vibrio mimicus, V. parahemolyticus) and 3 fungi (Candida albicans, Aspergillus niger, Sacharomyces cerevacae). keywords: activity; bangladesh; extract; indica; methanolic cache: bjp-2758.pdf plain text: bjp-2758.txt item: #526 of 942 id: bjp-27584 author: Salazar, Anuar Gómez; Pablo, Saudy Saret Pérez; Estévez, María Mirian Carmona; Meléndez, María Estela Camargo title: Diuretic activity of aqueous extract and smoothie preparation of Verbesina crocata in rat date: 2018 words: 3470 flesch: 56 summary: Diuretic activity of aqueous extract and smoothie prepa- ration of Verbesina crocata in rat. Bang- ladesh J Pharmacol. Diuretic activity of aqueous extract of V. crocata keywords: crocata; diuretic; extract; plant; smoothie cache: bjp-27584.pdf plain text: bjp-27584.txt item: #527 of 942 id: bjp-27605 author: Sasikumar, Kandasamy; Ghosh, Asit Ranjan title: Isolation of myristyl alcohol from Hybanthus enneaspermus date: 2017 words: 927 flesch: 49 summary: The soluble fraction of chloroform A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2017; 12: 113-114 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088; DOI: 10.3329/bjp.v12i2.27605 Letter to the Editor Figure 1: 1H NMR (A) and 13C NMR (B) spectrum of isolated compound (1-tetradecanol) from H. enneaspermus This work is licensed under a Creative Commons Attribution 4.0 International License. dipeptide alkaloids, aurantiamide acetate, isoarborinol, and β-sitosterol have been isolated (Patel et al., 2013) and also some of the identified compounds are alkyl alcohols, heteroxanthine, theophylline, theobromine, caffeine, tetramethyl trihydroxypurine, agnosterol, lanosterol, dihydrositosterol, cholestanol, cholesterol, dihydroagnosterol, gallic acid, catechin, galangin, kaempferol, thujyl alcohol, menthol, terpinol, sesquiter- pene and daucul from H. enneaspermus by gas chromatography (Retnam and De Britto, 2003). keywords: alcohol; bangladesh; enneaspermus; plant cache: bjp-27605.pdf plain text: bjp-27605.txt item: #528 of 942 id: bjp-27606 author: Shou, Di-Wen; Zheng, Yue-Lin title: Antitumor activity, cell cycle arrest and apoptosis induction in human colon cancer cell line by Primula macrophylla extracts date: 2017 words: 3595 flesch: 51 summary: Treatment of Colo-205 cells with different concentration of extract (0-80 μg/mL) significantly increased the side-scattering (SSC) pro- file due to increased cellular granularity because of chromatin fragmentation and significant decrease in forward-scattering (FSC) profile due to shrinkage of cells 250 200 150 100 50 0 S S C - A 0 µg/mL 250 200 150 100 50 0 S S C - A 10 µg/mL 250 200 150 100 50 0 S S C - A 20 µg/mL 250 200 150 100 50 0 S S C - A 40 µg/mL 101 102 103 104 105 250 200 150 100 50 0 S S C - A FSC-A 80 µg/mL Bangladesh J Pharmacol 2017; 12: 101-106 103 Figure 2: Methanol extract of P. macrophylla induced cell cycle arrest in COLO-205 cells at G0/G1 phase of cell cycle. Effect on dot-blot light scattering One of the important characteristics of any anti-cancer drug is the inhibition of cell growth proliferation and apoptosis induction in cancer cells (Lowe and Lin, 2000). keywords: apoptosis; cancer; cells; colo-205; cycle; extract; macrophylla; methanol cache: bjp-27606.pdf plain text: bjp-27606.txt item: #529 of 942 id: bjp-27620 author: Mirkheshti, Alireza; Memary, Elham; Shafiee, Hamed; Dahi, Mastaneh title: Effect of dexmedetomidine infusion on N-terminal pro-B-type natriuretic peptide level in patients with femoral shaft fractures under general anesthesia date: 2016 words: 3283 flesch: 56 summary: In addition, bleeding, changes in systolic and diastolic blood pressure in dexmedetomidine group was significantly less than the control group (p˂0.001). they evaluated the effects of dexmedetomidine on cardiac outcomes after non-cardiac surgery. keywords: blood; bnp; dexmedetomidine; group; patients; peptide; study; surgery cache: bjp-27620.pdf plain text: bjp-27620.txt item: #530 of 942 id: bjp-27658 author: Ganesan, Ayyappadasan; Mahesh, Amutha; Sundararaj, Jeya Prakash; Mani, Kalaiselvi; Ponnusamy, Ponmurugan title: Antihyperglycemic and anti-oxidant activity of various fraction of Parmotrema hababianum in streptozotocin-induced diabetic rat date: 2016 words: 3415 flesch: 54 summary: Anti-oxidant activity of lichen extracts 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical capturing assay Hydrogen free radical quenching assay was performed with different concentrations of lichen extracts (20, 50, 100, 200, 400, 800 and 1,000 µg/mL) in corresponding solvents (w/v). Anti-oxidant activities of aqueous extracts of selected plants. keywords: activity; anti; diabetes; diabetic; extracts; hababianum; level; lichen; rats cache: bjp-27658.pdf plain text: bjp-27658.txt item: #531 of 942 id: bjp-27663 author: Vijayalakshmi, Maruthamuthu; Ruckmani, Kandasamy title: Ferric reducing anti-oxidant power assay in plant extract date: 2016 words: 771 flesch: 52 summary:  Trichloroacetic acid (10%): 10 g of trichloroacetic acid was dissolved in 100 mL of deionised water.  Ascorbic acid (0.1%): 1 mg of ascorbic acid was dissolved in 1 mL of water. keywords: acid cache: bjp-27663.pdf plain text: bjp-27663.txt item: #532 of 942 id: bjp-27704 author: Shrikanth, Vineetha M.; Janardhan, Bhavya; More, Sunil S. title: In vitro neutralization of Eachis carinatus and Naja naja venom by Canthium parviflorum and its GC-MS analysis date: 2016 words: 4280 flesch: 54 summary: The present study focuses on the antivenom potential of thin layer chromatography (TLC) separated methanol extract of plant against E. carinatus and N. naja venom. Inhibition study was carried out by pre- incubating E. carinatus or N. naja venom with TLC separated bands for 30 min at 37°C. keywords: activity; band; carinatus; extract; methanol; min; naja; naja naja; naja venom; neutralization; parviflorum; tlc; venom cache: bjp-27704.pdf plain text: bjp-27704.txt item: #533 of 942 id: bjp-27707 author: Punitha, Soosaimanickam Carmel; Rajasekaran, Muthu title: Cardioprotective effect of Volvariella volvacea in streptozotocin administered rats date: 2016 words: 4728 flesch: 50 summary: (b) STZ treated group rats shows elongated QRS and QT. Glibenclamide and vitamin E-treated groups also exhibited marked increase over to control group rats. keywords: anti; control; group; mushroom; protein; rats; streptozotocin; vitamin; volvacea cache: bjp-27707.pdf plain text: bjp-27707.txt item: #534 of 942 id: bjp-27755 author: Xia, Ning title: Syringin exhibits anticancer effects in HeLa human cervical cancer cells by inducing apoptosis, cell cycle arrest and inhibition of cell migration date: 2016 words: 3191 flesch: 58 summary: Bangladesh J Pharmacol 2016; 11: 838-843 839 https://youtube.com/v/fnWR51P-BKg Results Anti-proliferative effects in HeLa cervical cancer cells The molecular structure of syringin molecule is shown in Figure 1A while as the anti-proliferative effects of the compound were assessed by MTT assay are shown in Figure Colony formation in HeLa cells The results indicate that syringin inhibits the colony formation in HeLa cervical cancer cells in a dose- dependent manner (Figure 2). keywords: apoptosis; cancer; cells; dose; effects; hela; migration; syringin cache: bjp-27755.pdf plain text: bjp-27755.txt item: #535 of 942 id: bjp-27906 author: Mohan, Kannan; Padmanaban, Muthusamy; Uthayakumar, Venkatachalam; Chandrasekhar, Ramachandran; Muralisankar, Thirunavukkarasu title: Cytotoxic activities of Ganoderma lucidum ethanol extract against HepG2 cell line date: 2016 words: 884 flesch: 51 summary: Muralisankar T. Cytotoxic ac- tivities of Ganoderma lucidum ethanol extract against HepG2 cell line. The present study was carried out to investigate the cytotoxicity properties of G. lucidum against HepG2 cell lines. keywords: cell; hepg2; lucidum cache: bjp-27906.pdf plain text: bjp-27906.txt item: #536 of 942 id: bjp-2800 author: Bhuiyan, Mohammad Nazrul Islam; Begum, Jaripa; Sultana, Mahbuba title: Chemical composition of leaf and seed essential oil of Coriandrum sativum L. from Bangladesh date: 2009 words: 2377 flesch: 59 summary: It is reported that coriander seed oil contains linalool (60-70%) and 20% hydrocarbons and the composition of the herb oil completely differs from the seed oil (Guenther, 1950). Rastogi and Mehrotra reported (1993) detection of - pinene, limonene, -phellandrene, eucalyptol, linalool, borneol, -caryophyllene, citronellol, geraniol, thymol, linalyl acetate, geranyl acetate, caryophyllene oxide, elemol and methyl heptenol in seed oil by TLC. keywords: acetate; acid; bangladesh; composition; linalool; oil; sativum; seed cache: bjp-2800.pdf plain text: bjp-2800.txt item: #537 of 942 id: bjp-28000 author: Dhivya, Sundaram; Latha, Subbiah; Selvamani, Palanisamy title: Enhancement of cognitive performance in mice and in vitro acetylcholinesterase inhibitory activity of 3,3’,4’,5,7-pentahydroxyflavone isolated from Cadaba indica date: 2016 words: 4847 flesch: 57 summary: Results Ethanol extract of C. indica furnished a white spot on purple background with the retention factor of 0.27. Figure 2 shows the effect of ethanol extract of C. indica in the presence or absence of scopolamine-induced memory deficit using the Y-maze task. keywords: acetylcholinesterase; activity; bangladesh; bioactive; compound; ethanol; extract; indica; mice; pharmacol cache: bjp-28000.pdf plain text: bjp-28000.txt item: #538 of 942 id: bjp-2801 author: Jebunnessa, -; Uddin, Shaikh Bokhtear; Mahabub-Uz-Zaman, M.; Akter, Rasheda; Ahmed, Nazim Uddin title: Antidiarrheal activity of ethanolic bark extract of Mitragyna diversifolia date: 2009 words: 1850 flesch: 54 summary: Wistar Albino rats were randomly divided in to three equal group (n=5) control group, positive control group and treated group where control group received only distilled water 2 mL/rat, positive control group received loperamide 1 mg/kg as standard and treated group received M. diversifolia bark extract at the dose 2 g/kg body weight. M. diversifolia bark extract also significantly (p<0.05) decreased the distance of gastrointestinal motility of rats. keywords: bark; diversifolia; extract; group; rats cache: bjp-2801.pdf plain text: bjp-2801.txt item: #539 of 942 id: bjp-28155 author: Choi, Kang-Ho; Hyeonju, Hong; Rather, Irfan A. title: Histopathological analysis of 2,4,5-trinitrobenzene sulphonic acid (TNBS)-induced mouse colitis date: 2016 words: 2119 flesch: 65 summary: 2,4,5-trinitrobenzene sulphonic acid (TNBS)- induced ulcerative colitis is one of the best The animal model of ulcerative colitis resembles to that of human. Therefore, histological analysis of ulcerative colitis tissue is one of the basic diagnostic requirements. keywords: colitis; ethanol; hour; paraffin; room; temperature cache: bjp-28155.pdf plain text: bjp-28155.txt item: #540 of 942 id: bjp-28178 author: Shukla, Shruti title: Estimation of aflatoxins in peanut or maize by enzyme linked immunosorbent assay date: 2016 words: 1654 flesch: 57 summary: The results for the quantitative analysis of aflatoxin levels, determined in tested peanut and maize (corn) food product samples by veratox total aflatoxin test kit (enzyme immunoassay), were in the range of 2.2- 11.2 μg/kg. This study reports step-by-step visual demonstration of determination of aflatoxin contents in peanut and maize (corn)-based food samples through employing enzyme linked immunosorbent assay (ELISA). keywords: aflatoxin; food; samples; wells cache: bjp-28178.pdf plain text: bjp-28178.txt item: #541 of 942 id: bjp-28185 author: Bajpai, Vivek K.; Majumder, Rajib; Park, Jae Gyu title: Isolation and purification of plant secondary metabolites using column-chromatographic technique date: 2016 words: 1892 flesch: 54 summary: Considering the deleterious effects of synthetic antibiotics, isolation, purification and characterization of novel types of plant secondary metabolites could be a safer alternative to synthetic compounds (Bajpai and Kang, 2011). PROTOCOL Isolation and purification of bioactive compounds from plant samples 1. keywords: column; compounds; plant; sample; solvent cache: bjp-28185.pdf plain text: bjp-28185.txt item: #542 of 942 id: bjp-28428 author: Karim, Nasiara; Ullah, Rahat; Khan, Imran; Raza, Muslim; Rauf, Abdur; Hizbullah, Syed M.; Ullah, Inam title: Anti-inflammatory activity and molecular docking studies of quinolyl-thienyl chalcone date: 2016 words: 1075 flesch: 52 summary: Chalcones possesses a broad spectrum of pharmacological activities. Anti-inflammatory activity and molecular docking studies of quinolyl-thienyl chalcone Sir, Chalcones, also known as benzylideneacetophenone, are group of compounds that belong to the flavonoids family and act as a precursur for flavonoid and isoflavonoids occurring in edible plants. keywords: carrageenan; chalcone; docking; quinolyl; thienyl cache: bjp-28428.pdf plain text: bjp-28428.txt item: #543 of 942 id: bjp-28569 author: Gopalan, Sivaperumal; Kulanthai, Kannnan; Sadashivam, Gnanavel; Pachiappan, Perumal; Rajamani, Sowmiya; Paramasivam, Deepak title: Extraction, isolation, characterization, semi-synthesis and antiplasmodial activity of Justicia adathoda leaves date: 2016 words: 3787 flesch: 56 summary: To overcome such disputes of malaria the rapid emergence of antiplasmodial activity is required. The results achieved suggest that both isolated and semi-synthetic compounds may serve as a lead compound to antiplasmodial activity. keywords: activity; adhatoda; compound; falciparum; va-1; vasicine cache: bjp-28569.pdf plain text: bjp-28569.txt item: #544 of 942 id: bjp-28588 author: Bajpai, Vivek K.; Kim, Na-Hyung; Kim, Kangmin title: Chemical derivatization of pharmaceutical samples prior to Gas-Chromatography and Mass-Spectrometry analysis date: 2016 words: 1761 flesch: 44 summary: Selection of solvent is very important for preparing GC samples. GC analysis is used for drug testing and environmental contaminant identification. keywords: analysis; chemical; compounds; derivatization; samples cache: bjp-28588.pdf plain text: bjp-28588.txt item: #545 of 942 id: bjp-28662 author: Rather, Irfan Ahmad; Bajpai, Vivek K.; Han, Jonghun; Nam, Gyeong-Jun title: Imiquimod-induced psoriasis-like skin inflammation in mouse model date: 2016 words: 1152 flesch: 64 summary: First two authors contributed equally First Published: 1 October, 2016 DOI: 10.3329/bjp.v11i4.28662 ABSTRACT Psoriasis is a skin disorder characterized by skin inflammation and plaques. Imiquimod- induced skin inflammation in animal model resembles with psoriasis. keywords: imiquimod; model; psoriasis; skin cache: bjp-28662.pdf plain text: bjp-28662.txt item: #546 of 942 id: bjp-28714 author: Laksmitawati, Dian Ratih; Widyastuti, Anisa; Karami, Nadia; Afifah, Ervi; Rihibiha, Dwi Davidson; Nufus, Hayatun; Widowati, Wahyu title: Anti-inflammatory effects of Anredera cordifolia and Piper crocatum extracts on lipopolysaccharide-stimulated macrophage cell line date: 2017 words: 4642 flesch: 58 summary: Anti-inflammatory effects of Anredera cordifolia and Piper crocatum extracts on lipopolysaccharide-stimulated macrophage cell line Dian Ratih Laksmitawati1, Anisa Widyastuti1, Nadia Karami1, Ervi Afifah1, Dwi Davidson Rihibiha2, Hayatun Nufus2 and Wahyu Widowati3 1Faculty of Pharmacy, Pancasila University, Jalan Srengseng Sawah, Jagakarsa, Jakarta Selatan 12640, Indonesia; 2Biomolecular and Biomedical Research Center, Aretha Medika Utama, Jl. Anti-inflammatory effects of phe- nolic compounds isolated from the fruits of Artocarpus heterophyllus. keywords: anti; cell; cordifolia; crocatum; et al; extracts; il-6; level; tnf cache: bjp-28714.pdf plain text: bjp-28714.txt item: #547 of 942 id: bjp-29059 author: Larik, Fayaz Ali; Saeed, Aamer; Channar, Pervaiz Ali; Ismail, Hammad; Dilshad, Erum; Mirza, Bushra title: New 1-octanoyl-3-aryl thiourea derivatives: Solvent-free synthesis, characterization and multi-target biological activities date: 2016 words: 6027 flesch: 65 summary: Accepted: 11 October 2016 Available Online: 14 November 2016 DOI: 10.3329/bjp.v11i4.29059 Cite this article: Saeed A, Larik FA, Channar PA, Is- mail H, Dilshad E, and Mirza B. New 1-octanoyl-3-aryl thiourea derivatives: solvent-free synthesis, characteriza- tion and multi-target biological activi- ties. Raza R, Saeed A, Arif M, Mahmood S, Muddassar M, keywords: activity; compounds; quint; saeed; synthesis; thioureas cache: bjp-29059.pdf plain text: bjp-29059.txt item: #548 of 942 id: bjp-29094 author: Chander, M. Punnam; Vijayachari, Paluru title: In vitro antimicrobial and anti-oxidant potentials of selected seaweeds of Andaman and Nicobar Islands, India date: 2016 words: 1241 flesch: 46 summary: Results obtained in the current study relieved that selected seaweed extracts were found to possess potential antimicrobial activity against tested organisms. Rattaya S, Benjakul S, Prodpran T. Extraction, antioxidative, and antimicrobial activities of brown seaweed extracts, Turbinaria ornate and Sargassum polycystum, grown in Thailand. keywords: andaman; anti; seaweeds cache: bjp-29094.pdf plain text: bjp-29094.txt item: #549 of 942 id: bjp-29184 author: Rabiei, Zahra; Rabiei, Sana title: A review on antidepressant effect of medicinal plants date: 2017 words: 8537 flesch: 50 summary: Therefore, adenylyl cyclase activity can be considered to be the biological index of depression (Li et al., 1999). The analgesic effects of this plant-based combination have been demonstrated, as well (Li et al., 2014). keywords: acid; activity; antagonist; antidepressant; brain; compounds; depression; effects; et al; extract; mice; officinalis; pharmacol; plants; rabiei; receptor; serotonin; stress; study; system; test cache: bjp-29184.pdf plain text: bjp-29184.txt item: #550 of 942 id: bjp-29227 author: Khan, Bilal Muhammad; Bakht, Jehan; Khan, Wajid title: Rhizome extracts of Acorus odoratus: Antifungal, anti-yeast, anti-oxidant and HPLC quantification date: 2017 words: 4635 flesch: 56 summary: Anti-oxidant Activity All the seven concentrations of each tested extract were able to scavenge DPPH free radicals (Figure 4). Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate anti-oxidant activity. keywords: acetate; acid; acorus; activity; anti; antifungal; butanol; et al; ethyl; extracts; gallic; rhizome; yeast cache: bjp-29227.pdf plain text: bjp-29227.txt item: #551 of 942 id: bjp-29255 author: Ahmad, Md. Ashraf; Misbahuddin, Mir; Ahmed, Sharmeen title: Increased count of Bacteroides fragilis in the feces of palmar arsenical keratosis patient date: 2016 words: 4376 flesch: 53 summary: Compared the data of before supplementation with 12 weeks after supplementation; Comparison done- H vs A: Healthy volunteers vs. arsenic exposed controls (before supplementation); H vs P: Healthy volunteers vs. arsenicosis patients (before supple- mentation); A vs P: Arsenic exposed controls vs arsenicosis patients (before supplementation); Failed to collect nail samples from 3 patients 738 Bangladesh J Pharmacol 2016; 11: 734-740 level of arsenic in nails (Ali et al., 2010); suggesting that the measurement of arsenic concentration in nails can be one of the important markers of chronic arsenic toxicity (Karagas et al., 1996; Caussy, 2005). As arsenic exposed control, 20 partici- pants were selected from the family members of arsenicosis sufferers. keywords: arsenic; arsenicosis; bacteria; colony; controls; feces; fragilis; keratosis; patients; supplementation; volunteers cache: bjp-29255.pdf plain text: bjp-29255.txt item: #552 of 942 id: bjp-29306 author: Rajagopal, Shanmuga Sundaram; Swaminathan, Gomathi; Manickam, Vijayabaskaran; Ramanathan, Sambathkumar title: Effect of Pedalium murex against lipopolysaccharide-induced neurotoxicity in substantia nigra of rat midbrain date: 2016 words: 1014 flesch: 42 summary: Bangladesh J Pharmacol. 2016; 11: 876-877. A single intraperitoneal injection of lipopolysaccharide A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2016; 11: 876-877 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088; DOI: 10.3329/bjp.v11i4.29306 Letter to the Editor Table keywords: extract; lipopolysaccharide; murex cache: bjp-29306.pdf plain text: bjp-29306.txt item: #553 of 942 id: bjp-29339 author: Thomas, Sinjumol; Mani, Bince title: Composition, antibacterial and anti-oxidant potentials of the essential oil of Hedychium matthewii date: 2017 words: 4922 flesch: 53 summary: Leaf and flower essential oils of H. gardnarianum reported the presence of and -pinenes as the major components (Medeiros et al., 2003). Essential oils obtained from H. spicatum, H. aurantiacum, H. coronarium and H. ellipticum exhibited good anti- oxidant potentials by quenching DPPH radicals and moderate to good Fe2+ chelating activity and may perhaps afford protection against oxidative damage (Joshi et al., 2008). keywords: acid; activity; anti; et al; hedychium; linalool; matthewii; oil; oils; scavenging cache: bjp-29339.pdf plain text: bjp-29339.txt item: #554 of 942 id: bjp-29507 author: Ferdoush, Jannatul; Parveen, Kohinoor; Ata, Maliha; Reza, Fahim Hasan; Rahman, Md. Sayedur title: Knowledge, perception and preparedness of future prescribers about antimicrobial stewardship date: 2016 words: 3830 flesch: 43 summary: Inappropriate use of antimicrobials (95%) and poor infection control (82%) were identified as contributors for the spread of antimicrobial resistance. Problems of antimicrobial resistance can be reduced if antimicro- bials are prescribed rationally 155 (91) keywords: antimicrobial; bangladesh; knowledge; medical; pharmacol; resistance; stewardship; students; use cache: bjp-29507.pdf plain text: bjp-29507.txt item: #555 of 942 id: bjp-29516 author: Rabbi, Fazle; Zada, Amir; Adhikari, Achyut; Jabeen, Almas; Nisar, Amna; Ullah, Irfan title: Sterculia diversifolia bears anti-cancer and immunomodulatory activities date: 2017 words: 3479 flesch: 52 summary: Bangladesh Journal of Pharmacology Research Article Sterculia diversifolia Sterculia diversifolia Sterculia diversifolia bears antibears antibears anti--- cancer and immunomodulatory cancer and immunomodulatory cancer and immunomodulatory activitiesactivitiesactivities BJP Introduction A variety of pharmacologically active compounds such as quercetin, apigenin and scopolin have been isolated from the leaves of Sterculia foetida (Rani et al., 2010). The methanolic extract of S. diversifolia and various fractions were investigated for anti-cancer activity against PC-3 cell lines (Table II). keywords: activity; cancer; cytotoxic; diversifolia; extract; positive; sterculia; test cache: bjp-29516.pdf plain text: bjp-29516.txt item: #556 of 942 id: bjp-29606 author: Alamgeer, .; Mushtaq, Muhammad Naveed title: Effect of aqueous extract of Thymus serpyllum on lipid profile and some liver enzymes in alloxan-induced diabetic rabbit date: 2017 words: 3007 flesch: 55 summary: HDLs levels of diabetic treated rabbits were not significantly altered. The current study was conducted to investigate the effects of aqueous extract of T. serpyllum on lipid profile and some liver enzyme levels in diabetic rabbits. keywords: alloxan; control; day; effect; extract; lipid; liver; profile; rabbits; serpyllum cache: bjp-29606.pdf plain text: bjp-29606.txt item: #557 of 942 id: bjp-29668 author: Boulacel, Ibtissem; Djarri, Lakhdar; Azzouzi, Salima; Medjroubi, Kamel; Demirtas, Ibrahim; Laouer, Hocine; Akkal, Salah title: Phytochemical studies and antibacterial activity of the aerial parts of Physospermum verticillatum date: 2017 words: 3866 flesch: 64 summary: Boulacel I, Djarri L, Azzouzi S, Me- djroubi K, Demirtas I, Laouer H, Ak- kal S. Phytochemical studies and antibacterial activity of the aerial parts of Physospermum verticillatum. 2017; 12: Phytochemical studies and antibacterial activity of the aerial parts of Physospermum verticillatum Ibtissem Boulacel1, Lakhdar Djarri1, Salima Azzouzi2, Kamel Medjroubi2, Ibrahim Demirtas2, Hocine Laouer3 and Salah Akkal1 1Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, Department of Chemistry, University of Mentouri Constantine1, Constantine 25000, Algeria; 2University of Çankırı Karatekin, Faculty of Science, Department of Chemistry, Ballica Campus, Çankırı 18100, Turkey; 3Laboratory of Natural Biological Resources Valorization, Faculty of Sciences, University of Setif, Setif 19000, Algeria. keywords: activity; ethyl; extracts; verticillatum cache: bjp-29668.pdf plain text: bjp-29668.txt item: #558 of 942 id: bjp-29675 author: Pandey, Ajit Kumar; Kashyap, Pranita P.; Kaur, Chanchal Deep title: Anti-inflammatory activity of novel Schiff bases by in vitro models date: 2017 words: 1684 flesch: 54 summary: Anti-inflammatory activity of novel Schiff bases by in vitro models. Anti-inflammatory activity of novel Schiff bases by in vitro models Sir, A comprehensive collection of enzyme activation, moderator release, cell relocation, tissue collapse and repair are involved in an inflammation reaction (Vane, 2000) for host defense and usually activated in most disease conditions. keywords: activity; compounds; inhibition; membrane; proteinase; test cache: bjp-29675.pdf plain text: bjp-29675.txt item: #559 of 942 id: bjp-29735 author: Al-Harbi, Reham; Al-wegaisi, Razan; Moharram, Fatma; Shaaban, Mona; Abd El-Rahman, Ola title: Antibacterial and anti-hemolytic activity of tannins from Pimenta dioica against methicillin resistant Staphylococcus aureus date: 2017 words: 3581 flesch: 50 summary: Effect of tested compounds on hemolysin production The effect of the compounds on hemolysin released by S. aureus was determined by adding tannins in a sub- MIC concentration (1/2 MIC) to S. aureus cultures. S. aureus are opportunistic pathogens as they can invade human body and cause a wide variety of acute and chronic infections. keywords: aureus; isolates; mrsa; r r; r s; s s; tannins cache: bjp-29735.pdf plain text: bjp-29735.txt item: #560 of 942 id: bjp-2980 author: Thakare, Sagar P.; Jain, Hitesh N.; Patil, Savita D.; Upadhyay, Umesh M. title: Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats date: 2009 words: 3445 flesch: 54 summary: Bile duct ligation induces imbalance between reactive oxygen species production and these anti-oxidant defense which results into oxidative stress through a series of events deregulates the cellular functions leading to hepatic damage (Sanmugapriya Bangladesh J Pharmacol 2009; 4: 126-130 129 Table III Effect of methanol extract of Cocculus hirsutus on glutathione level in bile duct ligated rats Group Gluthathione level μmol/mg of protein Normal saline treated 1.8 ± 0.0 Bile duct ligated 0.8 ± 0.0 Silymarin treated (50 mg/kg) 1.7 ± 0.0 Cocculus hirsutus extract (400 mg/kg) 1.4 ± 0.0 A B C D E F G Figure 1: (A) Histology of normal liver showing normal hepatocyte, prominent central vein and sinosoids; (B) Bile duct ligated liver showing necrosis and portal inflammation, lymphocyte infiltration; C) Sham treated liver showing normal liver histology, prominent central vein and hepatocytes; D) Silymarin-treated liver showing necrosis and portal inflammation decreases compared with bile duct ligation; E) Methanol extract (100 mg/kg) showing mild bile duct proliferation and portal inflammation; F) Metha- nol extract (200 mg/kg) showing few area of necrosis and fatty change are seen; G) Methanol extract (400 mg/kg) showing small areas of lymphocyte infiltration and restoration of cells near to normal are seen (Hematoxylin and Eosin stain X 100) and Venkataraman, 2006). Lee TY, Chang HH, Chenjenn H. Herb medicine ameliorates hepatic fibrosis in bile duct ligation rats. keywords: animals; bile; duct; extract; hirsutus; ligation; liver; rats cache: bjp-2980.pdf plain text: bjp-2980.txt item: #561 of 942 id: bjp-29940 author: Ahmed, Hussien; Abushouk, Abdelrahman Ibrahim; Gadelkarim, Mohamed; Mohamed, Arwa; Gabr, Mohamed; Negida, Ahmed title: Efficacy of daclatasvir plus peginterferon alfa and ribavirin for patients with chronic hepatitis C genotype 4 infection date: 2017 words: 6386 flesch: 62 summary: Swallow E, Song J, Yuan Y, Kalsekar A, Kelley C, Mu F, Signorovitch J. Daclatasvir + sofosbuvir versus standard of care for hepatitis C genotype 3: A matching-adjusted indirect comparison. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. keywords: daclatasvir; genotype; hcv; ifn; patients; peg; rbv; response; treatment cache: bjp-29940.pdf plain text: bjp-29940.txt item: #562 of 942 id: bjp-2996 author: Pattanayak, Suman; Nayak, Siva Shankar; Panda, Durgaprasad; Shende, Vikas title: Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats date: 2009 words: 3434 flesch: 54 summary: Methanolic extract of C. scarabaeoides reduced blood glucose level in streptozotocin-induced diabetic rats. The diabetic rats exhibiting blood glucose levels in the range of 200 and 300 mg/100 mL were selected for the studies. keywords: blood; extract; glucose; group; rats; scarabaeoides; streptozotocin cache: bjp-2996.pdf plain text: bjp-2996.txt item: #563 of 942 id: bjp-29962 author: Kariman, Hamid; Vajihi, Firoozeh; Amini, Afshin; Shahrami, Ali; Arhami-Dolatabadi, Ali; Shojaee, Majid; Baratloo, Alireza title: Hyoscine versus diazepam for the management of true vertigo in the emergency department date: 2017 words: 3741 flesch: 56 summary: For example, Ganança et al. in their study showed that clonazepam leads to complete relief of vertigo in 77.4% of vertigo patients (Gananca et al., 2002). It has also been effective in vertigo treatment as shown in various studies. keywords: diazepam; drug; group; hyoscine; patients; study; treatment; vertigo cache: bjp-29962.pdf plain text: bjp-29962.txt item: #564 of 942 id: bjp-29964 author: Setorki, Mahbubeh; Hooshmandi, Zahra title: Neuroprotective effect of Ziziphus spina-christi on brain injury induced by transient global cerebral ischemia and reperfusion in rat date: 2017 words: 5489 flesch: 61 summary: Treatment of ischemic rats with extract signifi- cantly increased the frequency of passes through the hidden platform. 5.4ab a: significant differences with b at p<0.05 and ab: no significant differ- ences between a and b at p<0.05 74 Bangladesh J Pharmacol 2017; 12: 69-76 christi leaf extract showed neuroprotective activity against induced brain ischemia, so it could reduce the brain damage caused by ischemia and reperfusion. keywords: brain; christi; day; extract; group; ischemia; rats; spina cache: bjp-29964.pdf plain text: bjp-29964.txt item: #565 of 942 id: bjp-29980 author: Hayat, Zaman; Chaudhry, Mueen Ahmad; Alamgeer, . title: Evaluation of a poly-herbal preparation for the treatment of peptic ulcer date: 2017 words: 3805 flesch: 53 summary: Calculation of the extent of gastric ulcer The intensity of ulcer lesions was evaluated by gross examination of stomach photographs and ulcer score was assigned. Ethanol is identified as a major risk factor for develop- ment of gastric ulcers (Sener et al., 2004). keywords: activity; effect; group; index; pharmacol; score; ulcer; ulcerene cache: bjp-29980.pdf plain text: bjp-29980.txt item: #566 of 942 id: bjp-29995 author: Tapadiya, Ganesh; Kale, Mayura A.; Saboo, Shweta title: Phytochemical characterization, anti-cancer and antimicrobial activity of isolated fractions of Alysicarpus vaginalis date: 2017 words: 3793 flesch: 52 summary: Further plant extract fractions were explored for their antimicrobial potential to confirm the traditional use of plant as an anti-infective agent (Rattanata et al., 2014; Silva et al., 2015). The four fractions were separated and subjected for in vitro antimitotic and anti-proliferative assays along with anti-cancer activity on two human cancers cell lines (SK-MEL-2 and Hep-G2). keywords: acetone; activity; butanol; cancer; cell; extract; fractions; http://www.sciencedirect.com/science/article/pii/s2221169115300368; plant cache: bjp-29995.pdf plain text: bjp-29995.txt item: #567 of 942 id: bjp-30205 author: Aleem, Ambreen; Janbaz, Khalid Hussain title: Ethnopharmacological evaluation of Cenchrus ciliaris for multiple gastrointestinal disorders date: 2017 words: 5440 flesch: 53 summary: The decrease in the spontaneous movements of jejunum by crude extract is assumed to be mediated through Ca2+ channels blockade (Janbaz et al., 2012), as it was earlier observed that the antispasmodic constituents found in various medicinal plants inhibited the Ca2+ movement to produce their effect (Gilani et al., 2005a, 2005b). The chicks of experimental (Group 3, 4 and 5) received an oral dose of crude extract of C. ciliaris at the doses of 75, 100 and 150 mg/kg (solubilized in normal saline). keywords: activity; calcium; ciliaris; contractions; control; effect; extract; pharmacol cache: bjp-30205.pdf plain text: bjp-30205.txt item: #568 of 942 id: bjp-30252 author: Mohan, K.; Padmanaban, A. M.; Uthayakumar, V.; Chandirasekar, R.; Muralisankar, T.; Chithra, E. title: Anti-cancer effect of the polysaccharide extract from the Ganoderma lucidum against HeLa cell lines date: 2017 words: 1080 flesch: 49 summary: It was then evaporated at low temperature and lyophilized to obtain G. lucidum polysaccharide (900 mg) as a light brown powder. Free radical scavenging of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes and immunity activities in cervical carcinoma rats. keywords: cell; extract; hela; lucidum; polysaccharide cache: bjp-30252.pdf plain text: bjp-30252.txt item: #569 of 942 id: bjp-30257 author: Maruthamuthu, Vijayalakshmi; Kandasamy, Ruckmani title: Bronchodilatory effect of Myxopyrum serratulum in animal model date: 2017 words: 4727 flesch: 49 summary: Bangladesh Journal of Pharmacology Research Article Bronchodilatory effect of Bronchodilatory effect of Bronchodilatory effect of Myxopy-Myxopy-Myxopy- rum serratulum rum serratulum rum serratulum in animal modelin animal modelin animal model BJP Introduction Bronchial asthma is a chronic inflammatory disease of the airway. Bronchodilatory effect of Myxopyrum serratulum in animal model Vijayalakshmi Maruthamuthu1 and Ruckmani Kandasamy1,2 1Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational, Research (Centre), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620-024, Tamilnadu, India; 2 National Facility for Drug Development for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620-024, Tamilnadu, India. http://www.bioxbio.com/if/html/BANGL-J-PHARMACOL.html the presence of flavonoids, saponins, terpenoids, carbohydrates, ursolic acid (Sudharmini and Ashalatha, 2008) and myxopyroside, its 6-o-acetyl-7-o-(E/Z)-p- methoxycinnamoyl esters (2/3) of dimethyl forsythide (Franzyk et al., 2001). keywords: effect; extract; guinea; histamine; pharmacol; pig; serratulum; theophylline; tracheal cache: bjp-30257.pdf plain text: bjp-30257.txt item: #570 of 942 id: bjp-30381 author: Abdolrazaghnejad, Ali; Banaie, Mohsen title: Fentanyl-midazolam vs. midazolam-ketamine regarding patient sedation analgesia for emergency orthopedic procedures date: 2017 words: 3733 flesch: 54 summary: In addition, certain factors such as patients with fractures or dislocations and the need to monitor such patients in a separate unit of the Emergency Department reduced significantly the number of patients included. The potential benefits of effective sedation prior to reduction include the reduced anxiety and distress of the patient, providing comfort followed by more cooperation of patients, improvement of the success of the procedure and obviation the general anesthesia (Alimohammadi et al., 2014; Migita et al., 2006). keywords: department; emergency; fentanyl; group; ketamine; midazolam; patients; sedation; study cache: bjp-30381.pdf plain text: bjp-30381.txt item: #571 of 942 id: bjp-30417 author: Mahdavi, Reza; Kolahi, Sousan; Attari, Vahideh Ebrahimzadeh; Mahdavi, Aida Malek title: L-Carnitine supplementation ameliorates serum tumor necrosis factor-alpha and matrix metalloproteinase-3 in knee osteoarthritis women date: 2017 words: 4567 flesch: 50 summary: Previous in vitro and animal studies demonstra- ted inhibitory effects of L-carnitine on MMPs expre- ssion (Bianchi et al., 2014; Deng et al., 2014). Conclusion L-carnitine treatment has beneficial effects in reducing inflammatory biomarkers in knee osteoarthritis patients which subsequently leads to alleviation of the disease symptoms. keywords: baseline; carnitine; effects; et al; group; knee; osteoarthritis; patients; placebo; serum; study; supplementation; treatment cache: bjp-30417.pdf plain text: bjp-30417.txt item: #572 of 942 id: bjp-30465 author: Khalil, Nadia Bintha; Misbahuddin, Mir; Sattar, Abu Naser Ibne title: Pattern of skin bacteria in palmar arsenical keratosis date: 2016 words: 1924 flesch: 56 summary: Abstract The aim of the present study was to examine the involvement of skin bacteria in the pathogenesis of keratosis. Pattern of skin bacteria in pal- mar arsenical keratosis. keywords: arsenic; arsenicosis; keratosis; palm; skin; spp cache: bjp-30465.pdf plain text: bjp-30465.txt item: #573 of 942 id: bjp-30539 author: Khalil, Abdul Wajid; Iqbal, Zafar; Adhikari, Achyut title: Chemical composition, phytochemical analysis and antimicrobial activity of Boerhavia procumbens date: 2017 words: 5427 flesch: 60 summary: Arginine 0.1 ± 0.0c 3.7 ± 0.0b 8.9 ± 0.0a Lysine 0.0 ± 0.0 0.4 ± 0.0b 4.8 ± 0.0a Leucine 0.0 ± 0.0 0.7 ± 0.1a 0.7 ± 0.0a Methionine 0.1 ± 0.0c 1.1 ± 0.0b 3.8 ± 0.0a Valine 0.1 ± 0.0c 3.6 ± 0.0a 2.9 ± 0.0b Phenylalanine 0.1 ± 0.0c 1.8 ± 0.0b 3.4 ± 0.0a Values are mean ± SD; n = 3. 0.2a M. piriformis 8.5 ± 0.3c 0.0 ± 0.0d 12.5 ± 0.3b 24.4 ± 0.2a A. flavus 0.0 ± 0.0d 14.6 ± 0.2b 9.6 ± 0.2c 15.5 ± 0.2a Values are mean ± SD; n = 3. keywords: 0.0a; 0.0b; 0.0c; activity; analysis; extract; leaf; plant; procumbens; root; stem cache: bjp-30539.pdf plain text: bjp-30539.txt item: #574 of 942 id: bjp-30740 author: Shah, Akram Ullah; Khan, Rahmat Ali; Ahmed, Mushtaq title: Pharmacological activities of the methanolic extract of Quercus dialatata fruit date: 2017 words: 757 flesch: 49 summary: Bangladesh Journal of Pharmacology Volume: 12; Number 1; Year 2017 Cite this article as: Shah AU, Khan RA, Ahmed M. Pharmacological activities of methanolic crude extract of Quercus dialatata fruit. Protocol of Duraipandiyan and Ignacimuthu (2009) was used to screen cytotoxic, DPPH and antifungal activities while Re et al. (1999) for ABTS and Nishikimi et al., (1972) for superoxide free radical scavenging activities. keywords: activities; bangladesh; extract cache: bjp-30740.pdf plain text: bjp-30740.txt item: #575 of 942 id: bjp-30863 author: Singh, Mukesh Kumar; Dhongade, Hemant; Tripathi, D. K. title: Phytochemical analysis and antimicrobial activity of different extracts of Orthosiphon pallidus date: 2017 words: 1047 flesch: 50 summary: Gentamicin/ fluconazole (20 µg/mL) Staphylococcus aure- us MTCC 3160 200 10 ± 0.5 10 ± 1.3 11 ± 3.6 21 ± 1.8 400 12 ± 0.5 11 ± 1.2 14 ± 3.6 800 15 ± 0.4 13 ± 1.3 16 ± 1.3 1600 16 ± 0.5 14 ± 1.2 18 ± 0.7 3200 18 ± 0.5 15 ± 1.2 19 ± 0.9 Streptococcus mutans MTCC 890 200 9 ± 0.2 8 ± 0.3 10 ± 1.1 22 ± 0.1 400 12 ± 1.2 11 ± 0.2 13 ± 1.2 800 13 ± 0.3 12 ± 1.0 14 ± 1.1 1600 15 ± 0.3 13 ± 0.1 17 ± 1.3 3200 16 ± 0.0 15 ± 0.1 18 ± 1.1 Bacillus coagulans MTCC 492 200 11 ± 1.1 10 ± 1.0 9 ± 1.0 20 ± 1.6 400 13 ± 1.2 12 ± 1.1 13 ± 1.1 800 14 ± 1.1 14 ± 1.2 15 ± 1.5 1600 16 ± 1.3 14 ± 2.0 16 ± 1.3 3200 18 ± 1.2 16 ± 1.3 17 ± 1.4 Candia albicans MTCC 3017 200 6 ± 0.4 7 ± 1.4 9 ± 0.7 18 ± 0.8 400 8 ± 0.2 8 ± 1.1 11 ± 0.5 800 9 ± 0.3 10 ± 1.1 12 ± 0.3 1600 10 ± 1.6 11 ± 2.4 13 ± 1.5 3200 11 ± 1.0 12 ± 1.0 15 ± 0.6 Results are expressed as Mean ± SD of three replicates http://www.bioxbio.com/if/html/BANGL-J-PHARMACOL.html activity of all extracts was compared using gentamicin and fluconazole (20 µg/mL) as a standards and dimethyl sulfoxide as control. The aqueous extract contains carbohydrate, glycoside and tannin and hydroalcoholic extract contained carbohydrate, tannin and flavonoid. keywords: activity; extracts; pallidus cache: bjp-30863.pdf plain text: bjp-30863.txt item: #576 of 942 id: bjp-30872 author: Manoharan, Dhineshkumar; Kulanthai, Kannan; Sadhasivam, Gnanavel; Raji, Vijayan; Thayumanavan, Paalvannan title: Synthesis, characterization and evaluation of antidiabetic activity of novel indoline derivatives date: 2017 words: 4601 flesch: 62 summary: Abstract Series of indoline derivatives were synthesized using N-(4-aminophenyl) indoline-1-carbothiamide as a precursor. In vitro antidiabetic activity of indoline derivatives The α-amylase inhibitory activities were performed by (Nickavar and Amin, 2011), which was originally pro- posed by (Patil et al., 2013). keywords: activity; indoline; nmr; stretch; synthesis cache: bjp-30872.pdf plain text: bjp-30872.txt item: #577 of 942 id: bjp-30892 author: Bahuguna, Ashutosh; Khan, Imran; Bajpai, Vivek K.; Kang, Sun Chul title: MTT assay to evaluate the cytotoxic potential of a drug date: 2017 words: 1898 flesch: 58 summary: Correspondence to Vivek K. Bajpai at vbiotech04@gmail.com and Sun Chul Kang at sckang@daegu.ac.kr Published: 8 April, 2017 DOI: 10.3329/bjp.v12i2.30892 ABSTRACT Quantification of cell viability and proliferation form the fundamental for numerous in vitro assays in response to external factors. Other methods used for the assessment of cell viability based on various cellular functions such as enzyme activity, cell membrane permeability, cell adherence, ATP production, co-enzyme production, and nucleotide uptake activity. keywords: assay; cell; mtt; number; solution; viability cache: bjp-30892.pdf plain text: bjp-30892.txt item: #578 of 942 id: bjp-30985 author: Yao, Xiang-Yang; Bai, Qin title: Taraxerol protects the human hepatic L02 cells from hydrogen peroxide-induced apoptosis date: 2017 words: 3913 flesch: 60 summary: In this study, we assessed taraxerol on H2O2- induced apoptotic effect in L02 cells, and determined the activation of caspases-3, PARP, Bcl-2, Bax and MAPK. However, as shown in Figure 1B, taraxerol alone did not signifi- cantly affect the cell viability of L02 cells even at the dose of 200 μM. Effect on H2O2-induced cell viability and LDH leakage 134 Bangladesh J Pharmacol 2017; 12: 133-139 H2O2 (mM) 0 0.1 0.2 0.4 0.6 0.8 1.0 R el at iv e ce ll vi ab ili ty (% ) a b b b b A 120 80 40 0 R el at iv e ce ll vi ab ili ty (% ) B 120 80 40 0 0 20 40 60 80 100 200 Taraxerol (µM) keywords: apoptosis; cells; cleaved; h2o2; jnk; l02; p38; parp; taraxerol cache: bjp-30985.pdf plain text: bjp-30985.txt item: #579 of 942 id: bjp-31020 author: Padmavathy, Jagannathan; Devarajan, Saravanan title: Natural product as a source of prodrug date: 2017 words: 6192 flesch: 53 summary: Duocarmycins Duocarmycins such as A, B1, B2, C1, C2, D, SA and CC- 1065 are natural prodrugs isolated from the Strepto- myces. Leinamycin E1 Leinamycin E1 is natural prodrug isolated from the Streptomyces atroolivaceus. keywords: acid; activities; activity; bacteria; bangladesh; cancer; cells; compound; development; discovery; drugs; enzyme; et al; form; med; natural; pharmacol; plants; present; prodrug; products; source; treatment cache: bjp-31020.pdf plain text: bjp-31020.txt item: #580 of 942 id: bjp-31122 author: Usha, Talambedu; Middha, Sushil Kumar; Narzary, Derhasat; Brahma, Birendra Kumar; Goyal, Arvind Kumar title: In silico and in vivo based scientific evaluation of traditional anti-diabetic herb Hodgsonia heteroclita date: 2017 words: 946 flesch: 49 summary: Bangladesh J Pharmacol. 2017; 12: 165-66. A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2017; 12: 165-166 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088; DOI: 10.3329/bjp.v12i2.31122 Letter to the Editor Table keywords: gsk-3; heteroclita; india cache: bjp-31122.pdf plain text: bjp-31122.txt item: #581 of 942 id: bjp-31238 author: Kou, Ni; Cho, Hyejoung; Kim, Hye-Eun; Sun, Qiaochu; Ahn, Kyuhyeon; Ji, Hyeongjoon; Choi, Hongran; Kim, Okjoon title: Anti-cancer effect of Atractylodes macrocephala extract by double induction of apoptotic and autophagic cell death in head and neck cancer cells date: 2017 words: 4099 flesch: 51 summary: Both cell apoptosis and autophagy are effective and secure methods ensuring a reduction in the number of cancer cells. Chemotherapy and irradiation, which are used to treat cancer, induce apoptosis and decrease the number of cancer cells. keywords: apoptosis; autophagy; cancer; cells; death; extract; head; hours; macrocephala; neck; pathway cache: bjp-31238.pdf plain text: bjp-31238.txt item: #582 of 942 id: bjp-31390 author: Shukla, Shruti; Bajpai, Vivek K. title: Visual demonstration of transmission electron microscopy for intracellular observation of a single bacterial cell date: 2017 words: 2334 flesch: 54 summary: [We can adjust the concentration of bacterial cell culture as per the image requirement as if we require a bunch of bacterial cells, use high concentration of pellet and if required single or separated bacterial cells, dilute the pellet in 0.05M PBS buffer (pH 7.4). Bacterial sample preparation of TEM 1. keywords: electron; microscopy; sample; tem; transmission cache: bjp-31390.pdf plain text: bjp-31390.txt item: #583 of 942 id: bjp-31428 author: Arif, Mubeen; Jabeen, Furukh; Saeed, Aamer; Qureshi, Irfan Zia; Mushtaq, Nadia title: A new class of potential antidiabetic acetohydrazides: Synthesis, in vivo antidiabetic activity and molecular docking studies date: 2017 words: 10847 flesch: 62 summary: N΄-(3-flourobenzylidene)-2-(5-(pyridin-3-yl)-2H- tetrazol-2-yl)acetohydrazide (9l) Yield: 82%; off white solid; m.p.: 263°C (decomp.); Rf: 0.42 (ethyl acetate : n-hexane 2:1); FTIR (ATR, υ/cm-1): 3376 (N-H), 3116 (Ar C-H), 1685 (C=N), 1665 (amide C=O), 1571 (Ar C=C), 1271 (N=N-N); 1H NMR (300 MHz, DMSO-d6): δ 12.08 (br, 1H, NH), 9.21 (d, J = 1.5 Hz, 1H, Ar-H), 8.74 (dd, J = 1.5, 4.8 Hz, 1H, Ar-H), 8.60- 8.51 (m, 1H, Ar-H), 8.21 (s, 1H, CH=N), 7.81-7.62 (m, 4H, Ar-H), 7.54-7.47 (m, 1H, Ar-H), 6.15 (s, 2H, CH2); 13C NMR: (75 MHz, DMSO-d6): 166.9 (C=O) , 163.0 322 Bangladesh J Pharmacol 2017; 12: 319-332 (C=N, tetrazole), 162.8, 159.9, 152.1, 147.1, 138.2, 135.7, 134.1, 132.8, 129.7, 126.0, 121.4, 119.6, 54.23; LC-MS (m/ z): (M)+, 326; Elemental analysis calculation for C15H12FN7O (%): C, 55.38; H, 3.72; N, 30.14; Found: C, 55.27; H, 3.81; N, 30.16. N΄-(2-flourobenzylidene)-2-(5-(pyridin-3-yl)-2H- tetrazol-2-yl)acetohydrazide (9m) Yield: 80%; off white solid; m.p.: 252°C (decomp.); Rf: 0.42 (ethyl acetate : n-hexane 2:1); FTIR (ATR, υ/cm-1): 3387 (N-H), 3117 (Ar C-H), 1687 (C=N), 1662 (amide C=O), 1588 (Ar C=C), 1277 (N=N-N); 1H NMR (300 MHz, DMSO-d6): δ 12.10 (br, 1H, NH), 9.25 (s, 1H, Ar- H), 8.82-8.74 (m, 1H, Ar-H), 8.50-8.42 (m, 1H, Ar-H), 8.28 (s, 1H, CH=N), 8.05-7.88 (m, 1H, Ar-H), 7.62 (dd, J = 8.1, 4.8 Hz, 1H, Ar-H), 7.54-7.46 (m, 1H, Ar-H), 7.33- 7.29 (m, 2H, Ar-H), 6.20 (s, 2H, CH2); 13C NMR: (75 MHz, DMSO-d6): 166.7 (C=O), 162.8 (C=N, tetrazole), 162.6, 159.5, 151.9, 147.6, 138.3, 138.2, 134.4, 132.7, 127.1, 125.3, 124.8, 123.4; LC-MS (m/z): (M)+, 326; Elemental analysis calculation for C15H12FN7O (%): C, 55.38; H, 3.72; N, 30.14; Found: C, 55.27; H, 3.81; N, 30.16. keywords: 13c; = o; acetate; amide c; analysis; ar c; c =; ch =; dmso; ethyl; mhz; nmr; solid; tetrazole cache: bjp-31428.pdf plain text: bjp-31428.txt item: #584 of 942 id: bjp-31694 author: Saeed, Anam; Wahid, Fazli; Rasheed, Hafiz Majid; Qayyum, Rahila; Shah, Abdul Jabbar; Khan, Taous title: Effects of Heliotropium strigosum and Trapa bicornis in hyperactive gut disorders date: 2017 words: 4442 flesch: 54 summary: Control (saline) 10 mL/kg 5.2 ± 0.5 0 ± 0 9.6 ± 4.0 Castor oil 10 mL/kg 16 ± 0.7 96.2 ± 2.3 2.6 ± 2.3 H. strigosum 100 mg/kg 6.3 ± 0.7 76.0 ± 1.0 10.3 ± 1.0 300 mg/kg 5.0 ± 1.5 56.0 ± 1.2 37.1a ± 0.6 1,000 mg/kg 4.6 ± 1.9 20.4 ± 1.8 83.3c ± 5.9 T. bicornis 100 mg/kg 10.2 ± 3.2 71.0 ± 2.2 14.2 ± 4.9 300 mg/kg 8.6 ± 2.8 53.6 ± 2.0 39.6a ± 6.0 1,000 mg/kg 5.4 ± 3.0 27.2 ± 0.9 76.4b ± 0.9 1 mg/kg 8.4 ± 0.6 66.9 ± 3.7 31.6a ± 3.3 Verapamil 3 mg/kg 6.2 ± 0.4 47.2 ± 5.0 60.1b ± 4.2 10 mg/kg 4.2 ± 0.2 24.6 ± 1.7 85.3c ± 6.0 n=5 in each case; Mean ± SEM; ap<0.05, bp<0.01 and cp<0.001 vs control; Student’s t-test Figure 1: TLC and HPLC analysis of H. strigosum and T. bicornis crude extracts; (A) TLC chromatogram, (B) Figure 2: Tracing showing normal contraction and relaxation (control) of rabbit jejunum and relaxant effect of Trapa bicornis crude extract (Tb.Cr) on spontaneous contractions in isolated rabbit’s jejunum preparation Figure 3: Graphical representation of (A) relaxant effect of Trapa bicornis crude extract (Tb.Cr), (B) verapamil on spontaneous and K+-induced contractions in isolated rabbit’s jejunum preparation, (C) concentration-response curves of calcium by different con- centrations of T. bicornis, and (D) verapamil on isolated rabbit’s jejunum preparation. keywords: bicornis; calcium; effect; extracts; strigosum; verapamil cache: bjp-31694.pdf plain text: bjp-31694.txt item: #585 of 942 id: bjp-31764 author: Tatipamula, Vinay Bharadwaj; Killari, Kishore Naidu; Ketha, Alekhya; Sastry, Vedula Girija title: Taxithelium napalense acts against free radicals and diabetes mellitus date: 2017 words: 4465 flesch: 53 summary: Acute toxicity studies The toxicity of ethanolic extract and fraction I-V were performed as per OECD guidelines. Glibencla- mide (50 mg/kg) and 0.5% carboxymethylcellulose were administered to animals as standard and control respectively Effects on normal and glucose-loaded rats: Fasting blood glucose levels of primarily divided eight groups' (n = 6) animals were deliberated and after 300 and 600 mg/kg body weight dose of ethanolic extract and 150 and 300 mg/kg body weight of fraction IV and V were administrated orally. keywords: animals; day; diabetic; extract; fraction; napalense cache: bjp-31764.pdf plain text: bjp-31764.txt item: #586 of 942 id: bjp-31843 author: Nile, Shivraj Hariram; Keum, Young Soo title: Anti-oxidant, anti-inflammatory and enzyme inhibitory activities of 10 selected Unani herbs date: 2017 words: 1559 flesch: 51 summary: Antioxidant, anti-inflammatory and enzyme inhibitory activities of 10 selected Unani herbs. You must attribute the work in the manner specified by the author or licensor mailto:nileshivraj@gmail.com mailto:nileshivraj@konkuk.ac.kr Bangladesh J Pharmacol 2017; 12: 162-164 163 Table I Phytochemical analysis, anti-oxidant and enzyme inhibitory activities of the extracts of selected herbs Botanical name Rubia cordifo- lia Rauwolfia serpentina Origa- num vulgare Hyssopus officinalis Cicho- rium intybus Malva syl- vestris Portu- laca oleracea keywords: activities; activity; antioxidant; enzyme; extract cache: bjp-31843.pdf plain text: bjp-31843.txt item: #587 of 942 id: bjp-31950 author: Hamad, Alshammari Fanar; Han, Jong-Hun; Rather, Irfan Ahmad title: Mouse model of DNCB-induced atopic dermatitis date: 2017 words: 1653 flesch: 66 summary: The advantages of using mouse model for atopic dermatitis are: a) Small size;, b) Relatively low housing cost; c) Short generation time; d) large number of offspring; e) The criteria for mouse models of atopic dermatitis include clinical symptoms (dryness, scaling, erythema, erosion and excoriation), pruritus (scratching behavior), elevation of total and specific IgE and increased mast cells in the upper dermis (Matsuoka et al., 2003). keywords: atopic; dermatitis; dncb; model; mouse; skin cache: bjp-31950.pdf plain text: bjp-31950.txt item: #588 of 942 id: bjp-31965 author: Khan, Wajid; Bakht, Jehan; Khan, Bilal Muhammad title: In vitro antifungal, anti-oxidant and HPLC analysis of the extracts of Physalis philadelphica date: 2017 words: 4109 flesch: 57 summary: % A nt i-o xi da nt a ct iv ity A 0 50 100 150 200 250 Concentration 100 90 80 70 60 50 40 B 0 50 100 150 200 250 Concentration Figure 3: Anti-oxidant activity of the different extracts of the stem (A) and calyx (B) Methanol n-Hexane Ethyl acetate n-Butanol Water Gallic acid Bangladesh J Pharmacol 2017; 12: 313-318 315 the highest radical scavenging activity at 250 µg/mL. Anti-oxidant activities of flavonol derivates from the leaves and stem bark of Scutia buxifolia Reiss. keywords: acetate; activity; anti; concentration; ethyl; extracts; methanol; oxidant; plant; radical cache: bjp-31965.pdf plain text: bjp-31965.txt item: #589 of 942 id: bjp-32010 author: Iscan, Gökalp; Göger, Fatih; Demirci, Betül; Köse, Yavuz Bülent title: Chemical composition and biological activity of Nepeta cilicica date: 2017 words: 4157 flesch: 50 summary: Nepetalactone isomers 4a ,7 ,7a -nepetalactone, 4a ,7 ,7a - nepetalactone, 4a ,7 ,7a -nepetalactone, 4a ,7 ,7a - nepetalactoneand 4a ,7 ,7a -nepetalactone are consi- dered as biochemical indicator of the nepetalactone-rich group of Nepeta essential oils. Even though two studies have been reported on the chemical compo- sition of N. cilicica essential oil. keywords: acid; activity; cilicica; composition; compounds; extract; methanol; nepeta; oil; rri cache: bjp-32010.pdf plain text: bjp-32010.txt item: #590 of 942 id: bjp-32023 author: Saeed, Aamer; Shahzad, Danish; Larik, Fayaz Ali; Channar, Pervaiz Ali; Mahfooz, Haroon; Abbas, Qamar; Hassan, Mubashir; Raza, Hussain; Seo, Sung-Yum; Shabir, Ghulam title: Synthesis of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines as novel skin protecting and anti-aging agents date: 2017 words: 3540 flesch: 60 summary: Elastase inhibition activity assay The elastase inhibitory potency of synthetic compounds was determined by Thongyoo et al., 2009 method with some changes. Elastase enzyme degrades the elastin, hence inhibition of elastase activity can serve as an efficient way to protect skin aging. keywords: dmso; elastase; mhz; nmr; ppm; skin cache: bjp-32023.pdf plain text: bjp-32023.txt item: #591 of 942 id: bjp-32065 author: Kishore, Lalit; Kaur, Navpreet; Kajal, Anu; Singh, Randhir title: Extraction, characterization and evaluation of Eruca sativa against streptozotocin-induced diabetic nephropathy in rat date: 2017 words: 8440 flesch: 58 summary: Whereas, in diabetic rats fasting glucose level was found to be increased to 522.2 mg/dL from 324.8 mg/ dL. Administration of different doses of both extracts (100, 200 and 400 mg/kg) for 45 days, produced significant attenuation in elevated blood glucose level and maximum attenuation was observed with 400 mg/ kg of petroleum ether extract (173.8 ± 5.1 mg/dL) and hydroalcohol extract (127.8 ± 1.5 mg/dL) as compared to diabetic nephropathy control rats. In diabetic nephropathy control rats, a significant increase in urea (98.0 mg/dL), uric acid (15.5 mg/dL), creatinine (4.1 mg/dL) and BUN (0.04 mg/dL) levels was observed in STZ-induced diabetic nephropathy rats over the period of study. keywords: control; eha; ether; extract; hydroalcohol; level; nephropathy; petroleum; rats; sativa cache: bjp-32065.pdf plain text: bjp-32065.txt item: #592 of 942 id: bjp-32070 author: Zhang, Yanfang; Sun, Jianxun; Liu, Hui; Zhai, Xiaolin title: Effects of injection Shenkang and alprostadil combination on contrast-induced nephropathy in patient with diabetes complicated with mild to moderate renal insufficiency date: 2017 words: 3530 flesch: 50 summary: Contrast material- induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. Meanwhile, patients with diabetes and renal insufficiency have a significantly increased risk of CIN (Isobe et al., 2013). keywords: alprostadil; cin; contrast; creatinine; day; diabetes; group; injection; nephropathy; patients; serum cache: bjp-32070.pdf plain text: bjp-32070.txt item: #593 of 942 id: bjp-32126 author: Bai, Xuelian; Zhou, Ting; Lai, Tongfei; Li, Yicong; Chai, Jiale; Ni, Jiajun; Zhang, Huawei title: Isolation and antifungal screening of endophytic fungi from Erigeron canadensis date: 2017 words: 2350 flesch: 56 summary: Bangladesh Journal of Pharmacology Research Article Isolation and antifungal screening Isolation and antifungal screening Isolation and antifungal screening of endophytic fungi from of endophytic fungi from of endophytic fungi from Erigeron Erigeron Erigeron canadensiscanadensiscanadensis BJP Introduction Fungal infection is an important life-threatening dis- ease, which annually causes the death of millions of people (Xie et al., 2014) and the great loss of crop production (Bennett et al., 2012). Suppression of gastric ulcer in mice by administration of Erigeron canadensis extract. keywords: + +; antifungal; canadensis; erigeron; fungi; strains cache: bjp-32126.pdf plain text: bjp-32126.txt item: #594 of 942 id: bjp-32127 author: Rehman, Atta ur; Liaqat, Manal; Asghar, Rabia; Syed, Nawazish-i-Husain title: Evaluation of methanolic extract of Phragmites karka on carbon tetrachloride-induced liver fibrosis in rat date: 2017 words: 4012 flesch: 54 summary: Figure 4E and F show gross appearance of liver of animal treated with leaf and rhizome extract in CCl4 intoxicated rats which showed lesser degree of nodulation as compared to CCl4 intoxicated rat livers. Bangladesh Journal of Pharmacology Research Article Evaluation of methanolic extract of Evaluation of methanolic extract of Evaluation of methanolic extract of Phragmites karkaPhragmites karkaPhragmites karka on carbon tetra-on carbon tetra-on carbon tetra- chloridechloridechloride---induced liver fibrosis in ratinduced liver fibrosis in ratinduced liver fibrosis in rat BJP Introduction Hepatic fibrosis is a continuous wound healing res- ponse to repeated liver injuries which may be caused by viral hepatitis, alcohol abuse and other hepatotoxic agents (Friedrich-Rust et al., 2009; Rehman, 2014). keywords: cci; ccl4; control; expression; extract; fibrosis; figure; group; leaf; levels; liver; mrna; rhizome cache: bjp-32127.pdf plain text: bjp-32127.txt item: #595 of 942 id: bjp-32260 author: Qadir, Muhammad Imran; Ahmad, Zara title: Advances in hepatoprotective medicinal plants research date: 2017 words: 8359 flesch: 53 summary: Although numerous herbal medicines have universal status significantly but there are some limiting factors behind their usage including inconsistency of the herbal drugs, lack of recognition of active constituents, randomized controlled tentative trials, and lack of toxicological review (Saleem et al., 2010). Dried fruiting bodies Ethanol Carbon tetra- chloride Mouse ↓ALT, AST MDA (liver) suppression, ↑SOD, GSH-Px Prevent ↑ in liver wt, ↓Lipid droplet accumulation Liu et al., 2017 Oxalis stricta (Pickle plant) Whole plant Ethanol Paracetamol Rat Prevent GSH depletion ↓lipid peroxidation, AST, ALT, ALP, keywords: activity; alp; alt; anti; bangladesh; bilirubin; carbon; carbon tetrachloride; cat; damage; effect; et al; ethanol; extract; gsh; hepatoprotective; hepatotoxicity; leaf; liver; mda; med; medicinal; paracetamol; paracetamol rat; pharmacol; plants; rat; rat ↓ast; rats; res; sci; tetrachloride; tetrachloride rat; ↓ast cache: bjp-32260.pdf plain text: bjp-32260.txt item: #596 of 942 id: bjp-32310 author: Bencherchar, Ilhem; Demirtas, Ibrahim; Altun, Muhammed; Gul, Fatih; Sarri, Djamel; Benayache, Fadila; Benayache, Samir; Mekkiou, Ratiba title: HPLC analysis, anti-oxidant activity of Genista ferox and its anti-proliferative effect in HeLa cell line date: 2017 words: 4642 flesch: 57 summary: nd 1.0 Taxifolin 10.6 nd Trace Trace 0.3 Trace Trace Trace 1.0 Hesperidin 10.8 Trace Trace Trace Trace Trace Trace Trace 0.0 Apigetrin 10.9 Trace Trace Trace 0.7 16.1 Trace 1.1 3.3 Neohesperidin 11.1 Trace Trace Trace Trace Trace Trace Trace Trace Myricetin 11.9 nd Trace Trace Trace Trace 0.2 Trace Trace Baicalin 12.0 Trace Trace Trace Trace Trace Trace nd Trace Fisetin 12.1 Trace Trace Trace Trace Trace Trace Trace 0.8 Morin 13.0 0.8 0.1 1.5 0.2 5.0 0.1 6.4 1.2 Resveratrol 13.0 Trace Trace nd Trace Trace Trace nd Trace Quercetin 14.0 Trace Trace Trace Trace Trace Trace Trace Trace Silibinin 15.1 Trace Trace nd trace nd Trace nd Trace Apigenin 15.6 0.0 1.7 59.6 11.8 62.5 18.9 343.1 43.8 Naringenin 15.7 Trace Trace Trace 0.1 Trace 1.1 Trace 0.2 Kaempferol 15.7 nd Trace Trace 0.1 Trace 0.2 2.5 0.7 Diosmetin 16.1 nd 0.0 6.7 0.1 nd 0.2 51.7 0.9 Neochanin 17.7 nd Trace Trace Trace nd Trace Trace Trace Eupatorin 18.9 nd Trace Trace Trace nd Trace Trace nd Wogonin 19.8 Trace Trace Trace Trace nd Trace Trace Trace Galangin 20.5 nd Trace Trace Trace Trace Trace Trace Trace Biochanin A nd nd Trace Trace Trace nd trace trace Total flavonoids and phenolics 7.9 1.9 71.2 15.8 183.5 21.6 411.5 59.8 keywords: acetate; acid; activity; anti; butanol; ethyl; extract; methanol; oxidant; phenolic; stem; trace trace cache: bjp-32310.pdf plain text: bjp-32310.txt item: #597 of 942 id: bjp-3232 author: Yang, Zhan-Nan; Yang, Weiping; Peng, Quancai; He, Qiansong; Feng, Yong; Luo, Shiqiong; Yu, Zhengwen title: Volatile phytochemical composition of rhizome of ginger after extraction by headspace solid-phase microextraction, petrol ether extraction and steam distillation extraction date: 2009 words: 4834 flesch: 57 summary: The effects of different parameters, such as extraction fibers, extraction time, extraction temperature and particle size ranges, on the HS- SPME of rhizome of ginger were investigated. In the work discussed in this paper, to enable further understanding of the effects of different parameters, such as extraction fibers, extraction time, extraction temperature and particle size ranges, on HS-SPME of ginger. keywords: extraction; ginger; pee; sde; spme cache: bjp-3232.pdf plain text: bjp-3232.txt item: #598 of 942 id: bjp-32337 author: Saravanan, Renuka; Pemaiah, Brindha; Sridharan, Sriram; Narayanan, Mahesh; Ramalingam, Sivakumar title: Enhanced cytotoxic potential of Orthosiphon stamineus extract in MCF-7 cells through suppression of nucleolin and bcl2 date: 2017 words: 4791 flesch: 58 summary: Fluorescence microscopy analysis of nuclear fragmen- tation Fluorescence microscopy images of MCF-7 cancer cells in the absence and presence of compounds are shown in Figure 4. Expression level of nucleolin, bcl2, cytochrome c and bax in MCF-7 cell extract treated with different concentration of ethyl acetate extract of O. stamineus (A); Graphical representation of expression level of nucleolin, bcl2, cytochrome c keywords: acetate; acid; bax; bcl2; cancer; cells; cytochrome; ethyl; extract; fractions; mcf-7; nucleolin; stamineus cache: bjp-32337.pdf plain text: bjp-32337.txt item: #599 of 942 id: bjp-32410 author: Saleem, Uzma; Ali, Nauman; Ahmad, Bashir title: Protective and curative effects of Cestrum nocturnum on rabbit kidney date: 2017 words: 4840 flesch: 59 summary: Extract (500 mg/kg) Nephroprotective evaluation Pre-treatment values (0) 2.5 ± 0.1 2.5 ± 0.2 2.5 ± 0.1 2.4 ± 0.2 2.4 ± 0.2 2.7 ± 0.1 10 2.4 ± 0.3b 3.4 ± 0.3 2.3 ± 0.2b 2.9 ± 0.1ns 2.7 ± 0.2a 2.5 ± 0.1a 26 2.4 ± 0.2b 4.5 ± 0.1 1.8 ± 0.1b 3.3 ± 0.2b 2.8 ± 0.1b 2.4 ± 0.3b Nephrocurative evaluation Pre-treatment values (0) 2.2 ± 0.0 2.4 ± 0.1 2.2 ± 0.1 2.3 ± 0.1 2.3 ± 0.1 2.3 ± 0.1 10 2.5 ± 0.1b 3.5 ± 0.1 3.6 ± 0.2ns 3.6 ± 0.1ns 3.6 ± 0.1ns 3.6 ± 0.1ns 26 2.4 ± 0.2b 4.3 ± 0.0 2.4 ± 0.1b 3.1 ± 0.1b 2.9 ± 0.1b 2.7 ± 0.1b Values were presented as mean ± SEM; ap<0.01, bp<0.001 with respect to disease control group, ns = non-significant with respect to disease control group 286 Bangladesh J Pharmacol 2017; 12: 284-291 was also present (Figure 1E). Uric acid (mg/dL) levels Pre-treatment values (0) 2.4 ± 0.0 2.4 ± 0.0 2.5 ± 0.0 2.4 ± 0.0 2.5 ± 0.0 2.4 ± 0.0 10 2.5 ± 0.0c 4.2 ± 0.0 2.9 ± 0.0c 3.3 ± 0.0c 3.2 ± 0.0c 3.2 ± 0.0c 20 2.4 ± 0.0c 4.5 ± 0.0 2.8 ± 0.0c 3.4 ± 0.0c 3.3 ± 0.0c 3.1 ± 0.0c 26 2.5 ± 0.0c 4.6 ± 0.0 2.8 ± 0.0c 3.3 ± 0.0c 3.2 ± 0.0c 3.0 ± 0.0c Values were presented as mean ± SEM; ap<0.05; bp<0.01; cp<0.001 with respect to disease control group, ns = non-significant with respect to disease control group Bangladesh J Pharmacol 2017; 12: 284-291 287 view that the oxidative stress is main contributor in nephrotoxicity induced by gentamicin (Palmer, 2002; keywords: 0.0c; extract; gentamicin; levels; nocturnum; study; treatment; ± 0.1c cache: bjp-32410.pdf plain text: bjp-32410.txt item: #600 of 942 id: bjp-32413 author: Lan, Wei; Zhang, Hong Ping; Wang, Ying; Jiang, Min; Li, Qian; An, Dongqing title: Antihypertensive effect of piperitenone oxide on spontaneously hypertensive rat by regulating calcium balance and reducing endothelin-1 secretion date: 2017 words: 4599 flesch: 49 summary: Moreover, oral piperitenone oxide can significantly impair the serum ET-1 level in the SHR in S ys to lic b lo od p re ss ur e (m m H g) 250 200 150 100 50 0 b b a Figure 1: Effect of piperitenone oxide on (A) systolic blood pressure and (B) serum endothelin-1 (ET-1) level in spontane- ously hypertensive rat (SHR). Bangladesh Journal of Pharmacology Research Article Antihypertensive effect of Antihypertensive effect of Antihypertensive effect of piperitenone oxide on spontane-piperitenone oxide on spontane-piperitenone oxide on spontane- ously hypertensive rat by regulating ously hypertensive rat by regulating ously hypertensive rat by regulating calcium balance and reducing en-calcium balance and reducing en-calcium balance and reducing en- dothelindothelindothelin---1 secretion1 secretion1 secretion BJP Introduction Hypertension is an important risk factor for the cardio- vascular disease, cerebrovascular disease and kidney failure worldwide, causing an estimated 7.5 million deaths per year (World Health Organization, 2009). keywords: ca2; control; effect; endothelium; et-1; oxide; piperitenone; piperitenone oxide; rat; rings cache: bjp-32413.pdf plain text: bjp-32413.txt item: #601 of 942 id: bjp-32435 author: Sasikumar, Kandasamy; Ghosh, Asit Ranjan title: Larvicidal activity of prenyl xanthones from Garcinia mangostana against dengue vector date: 2017 words: 1556 flesch: 54 summary: In Ayurvedic medicine, the pericarp of this fruit has wide use against diarrhea, cholera and dysentery (Chopra et al., 1956). Dengue fever is endemic in the Southeast Asia and India, Bangladesh and Pakistan (Akram and Ahmed, 2005) and continues to increase with more severe forms of the disease such as dengue haemorrhagic fever and dengue shock syndrome or with unusual symptoms such as central nervous system involvement Pancharoen et al., 2002). keywords: bangladesh; dengue; larvicidal; methanol; vector; xanthones cache: bjp-32435.pdf plain text: bjp-32435.txt item: #602 of 942 id: bjp-32501 author: Hamad, Alshammari Fanar; Jeong, Hye-Young; Han, Jong-Hun; Rather, Irfan Ahmad title: Detection of cytosolic tRNA in mammal by Northern blot analysis date: 2017 words: 3455 flesch: 58 summary: Identify the distinct bands corresponding to 28S, 18S, and small RNA species such as 5.8S and tRNAs 3. Here we, utilize the similar strategy to detect the population of small RNA species such as cytosolic methionine initiator tRNA and glycine tRNA isolated from HEK293T cells. keywords: buffer; catalog; crosslinking; depc; gel; hybridization; membrane; rna; trna; water cache: bjp-32501.pdf plain text: bjp-32501.txt item: #603 of 942 id: bjp-32512 author: Alam, Fiaz; Saqib, Qazi Najam us title: Antidiabetic potential of Gaultheria trichophylla in mice date: 2017 words: 5024 flesch: 59 summary: Diabetic control mice showed an increased level of creatinine and urea and this level remained elevated throughout the period of study. It is known fact that the alloxan inducted diabetes results in loss of body weight as indicated by diabetic control group. keywords: antidiabetic; control; diabetic; effect; extract; glucose; groups; level; methanol; mice; standard; trichophylla cache: bjp-32512.pdf plain text: bjp-32512.txt item: #604 of 942 id: bjp-32525 author: Zheng, Lei; He, Hao; Shen, Xuji; Sun, Yanping title: Centipede Scolopendra suppresses cell growth in human epidermoid carcinoma cell A431 date: 2017 words: 5127 flesch: 59 summary: Migration and invasion potential of A431 cells were examined by wound-healing assays and matrigel invasion chamber assays. Colony formation assay A431 cells were plated in 6-well plates (100 cells per well). keywords: a431; a431 cells; cancer; cells; concentrations; control; cse; egfr; expression; figure; growth; hours; migration cache: bjp-32525.pdf plain text: bjp-32525.txt item: #605 of 942 id: bjp-32616 author: Bashir, Muhammad Farhan; Qadir, Muhammad Imran title: Effect of ginger extract on angiogenesis using CAM assay date: 2017 words: 3618 flesch: 57 summary: The compound revealed anti-angiogenic activity due to decrease in 200 160 120 80 40 X Range: 1374 pixels Z Range: 219.1 arbitray 687 -687 64 9 0 - 64 9 Y R an ge : 1 29 8 pi xe ls 0 A DSC_0077.JPG 250 200 150 100 50 X Range: 258 pixels Z Range: 254.1 arbitray 129 -129 14 0 0 - 14 0 Y R an ge : 2 80 p ix el s 0 B IMG-20170326-WA0057.JPG 200 160 120 80 40 X Range: 1031 pixels Z Range: 228.3 arbitray 516 -516 48 9 0 - 48 9 Y R an ge : 9 78 p ix el s 0 C DSC_0082.JPG 250 200 150 100 50 X Range: 1035 pixels Z Range: 252.1 arbitray 518 -518 54 4 0 - 54 4 Y R an ge : 1 08 8 pi xe ls 0 D DSC_0046.JPG 200 160 120 80 40 X Range: 1313 pixels Z Range: 222.8 arbitray 657 -657 64 7 0 - 64 7 Y R an ge : 1 29 3 pi xe ls 0 E DSC_0052.JPG Figure 1: Macroscopic assessment of CAM. Decreased in CAM region revealed anti-angiogenic actions in treated dilutions of ginger extract i.e. (B) 20 µL, (C) 50 µL, (D) 75 µL, (E) 150 µL Bangladesh J Pharmacol 2017; 12: 348-353 351 CAM region, blood vessels diameter and the standard surface roughness of CAM. keywords: angiogenesis; blood; cam; eggs; extract; ginger; ginger extract; surface; vessels cache: bjp-32616.pdf plain text: bjp-32616.txt item: #606 of 942 id: bjp-32622 author: Surana, Ajaykumar Rikhabchand; Wagh, Rajendra Dayaram title: GC-MS profiling and antidepressant-like effect of the extracts of Hamelia patens in animal model date: 2017 words: 4243 flesch: 58 summary: GC-MS profiling of chloroform extract was performed to find out the chemical constituents in bioactive fraction. The immobility time of chloroform extract was found to be 152.7 ± 11.0, 138.3 ± 5.7 sec and for methanol extract 185.3 ± 4.3, 186.5 ± 4.3 sec for the doses of 100 and 200 mg/kg/day on day 7 day respectively. keywords: activity; antidepressant; chloroform; extract; immobility; patens; tail; test cache: bjp-32622.pdf plain text: bjp-32622.txt item: #607 of 942 id: bjp-32646 author: Firdous, Sayeed Mohammed; Sautya, Dippayan title: Medicinal plants with wound healing potential date: 2018 words: 9493 flesch: 58 summary: Recently many plant extracts have been reported for wound healing activity and their cellular mechanism of wound healing has been studied extensively. Medicinal Plants with Wound Healing Poten- tial Many medicinal plants have been reported to show wound healing activity. keywords: activity; aloe; bangladesh; cells; collagen; dactylon; effect; et al; ethanolic; excision; extract; gel; healing; healing activity; medicinal; model; officinalis; ointment; pharmacol; plant; potential; rat; study; tissue; vera; wistar; wound; wound healing; wound model cache: bjp-32646.pdf plain text: bjp-32646.txt item: #608 of 942 id: bjp-32790 author: Saleem, Uzma; Haq, Ejaz ul; Ahmad, Bashir; Saleem, Mohammad title: Anti-ulcer activity of Cestrum nocturnum leaf in ethanol- and indomethacin-induced ulcer models date: 2017 words: 3582 flesch: 54 summary: Bangladesh Journal of Pharmacology Research Article AntiAntiAnti---ulcer activity of ulcer activity of ulcer activity of Cestrum noc-Cestrum noc-Cestrum noc- turnumturnumturnum leaf in ethanolleaf in ethanolleaf in ethanol--- and indo-and indo-and indo- methacinmethacinmethacin---induced ulcer modelsinduced ulcer modelsinduced ulcer models BJP Introduction In clinical practice peptic ulcer is the most common gastrointestinal disorder (Bafna and Balaraman, 2004). Number of plants have been investigated for anti-ulcer activity by number of researchers such as Mentha longifolia, Dalbergia sissoo, Morus nigra, Convolvulus arvensis and Chenopodium murale (Saleem et al., 2014; Mallhi et al., 2014; keywords: 0.1a; activity; anti; control; extract; group; ulcer cache: bjp-32790.pdf plain text: bjp-32790.txt item: #609 of 942 id: bjp-32796 author: Sarah, Quazi Sahely; Anny, Fatema Chowdhury; Misbahuddin, Mir title: Brine shrimp lethality assay date: 2017 words: 2104 flesch: 69 summary: Among them, brine shrimp lethality test is the simplest one, low cost and effective. The present study shows that hatched nauplii is unique for the preliminary cytotoxicity study. keywords: brine; eggs; nauplii; shrimp cache: bjp-32796.pdf plain text: bjp-32796.txt item: #610 of 942 id: bjp-32798 author: Uttra, Ambreen Malik; Alamgeer, . title: Assessment of anti-arthritic potential of Ephedra gerardiana by in vitro and in vivo methods date: 2017 words: 4478 flesch: 51 summary: 2 4 6 8 10 0.0 0.5 1.0 1.5 2.0 2.5 c b a ns ns b a a a a a a a a a a a a a a Arthritic control (3 mL/kg) Piroxicam (10 mg/kg) EGEAF (50 mg/kg) EGEAF (100 mg/kg) EGEAF (200 mg/kg) E E E E D 2.5 2.0 1.5 1.0 0.5 0.0 2 4 6 8 10 Figure 4: Effect of E. gerardiana extract and fractions: (A) Aqueous ethanolic extract, (B) Aqueous fraction, (C) n-butanol fraction, (D) Ethyl acetate fraction) on paw volume of formaldehyde induced arthritic rats. Moreover, E. gerardiana extract and fractions inhibited both phases of inflammation, therefore it acts centrally. keywords: control; denaturation; extract; fractions; gerardiana; test cache: bjp-32798.pdf plain text: bjp-32798.txt item: #611 of 942 id: bjp-32905 author: Saqib, Fatima; Hassan, Sakeena; Imran, Imran; Aleem, Ambreen; Janbaz, Khalid Hussain title: Pharmacological effects of Cnicus arvensis on the gastrointestinal system date: 2018 words: 5286 flesch: 57 summary: Discussion The methanol extract of C. arvensis was applied to the Figure 1: Effect of crude extract (A), petroleum ether extract (B), aqueous extract (C) and verapamil on isolated rabbit jejunum preparations Crude extract (mg/mL) 0.01 0.03 0.1 0.3 1.0 3.0 Petroleum ether extract (mg/mL) 0.01 0.03 0.1 0.3 Aqueous extract (mg/mL) 0.01 0.03 0.1 0.3 1.0 Verapamil (µM) 0.01 0.03 0.1 0.3 A B C D Figure 2: Additionally, 18 Bangladesh J Pharmacol 2018; 13: 16-22 pretreatment of the isolated rabbit jejunum preparation with crude extract (0.3-1.0 mg/mL) caused rightward shifting of concentration response curves for Ca2+ (Figure 3A, n = 5). keywords: activity; arvensis; concentration; contractions; extract; figure; jejunum; rabbit; tissue cache: bjp-32905.pdf plain text: bjp-32905.txt item: #612 of 942 id: bjp-32947 author: Akhtar, Usman; Ahmad, Mobasher title: Anti-fibrotic activity of medicinal plants date: 2017 words: 7873 flesch: 57 summary: For in vivo studies, carbon tetrachloride (CCl4 ) has been widely used to study liver fibrosis in experimental rodents (Uehara et al., 2014). After continuous injury oxidative stress is produced by several sources can influence liver fibrosis. keywords: activity; anti; carbon; ccl4; effect; et al; extract; injury; kim; liver; liver fibrosis; liver injury; model; pharmacol; plant; potential; rat; rats; serum; tetrachloride; treatment cache: bjp-32947.pdf plain text: bjp-32947.txt item: #613 of 942 id: bjp-32985 author: Ishtiaq, Saiqa; Khan Afridi, Muhammad Shaharyar; Masood, Nawal title: Amelioration of isoniazid and rifampicin-induced liver toxicity by Amaranthus graecizans subsp. silvestris in rat date: 2017 words: 3028 flesch: 54 summary: The plant possesses remarkable anti-oxidant properties that make it a suitable candidate to counter oxidative stress (Ishtiaq et al., 2014). The plant has also shown anti-choli- nesterase and anti-protease activity (Ishtiaq et al., 2017). keywords: extract; graecizans; group; hepatoprotective; isoniazid; liver; rifampicin cache: bjp-32985.pdf plain text: bjp-32985.txt item: #614 of 942 id: bjp-32995 author: Wang, Lai; Roy, Debmalya; Lin, Sen Sen; Yuan, Sheng Tao; Sun, Li title: Hypoglycemic effect of Camellia chrysantha extract on type 2 diabetic mice model date: 2017 words: 3173 flesch: 54 summary: Preparations of drugs and reagents The concentration of C. chrysantha extract was 10 mg/ mL prepared using 0.5% sodium carboxymethyl cellu- lose solution. Extracts of C. chrysantha groups were given corresponding extract of C. chrysantha 0.5% sodium carboxymethyl cellulose solution with the dose of 100 mg/kg in the way of intragastric administration. keywords: blood; chrysantha; dichloromethane; effect; ethyl; extract; glucose; mice cache: bjp-32995.pdf plain text: bjp-32995.txt item: #615 of 942 id: bjp-33108 author: Hasnat, Fahmida; Bhuiyan, Habiba Akhter; Misbahuddin, Mir title: Estimation of vitamin B12 in plasma by High Performance Liquid Chromatography date: 2017 words: 1974 flesch: 60 summary: The normal range of vitamin B12 in plasma of healthy subject is 200-900 pg/mL. Vitamin B12 in plasma, serum and urine can be measured by radioimmunoassay, enzyme-linked immunosorbent assay, microbiological assay (using Lactobacillus leichmannii; Girdwood, 1954), HPLC (Stefova et al., 1997), capillary electrophoresis, mass spectroscopy, Raman spectroscopy (Mayer et al., 1973), Fourier transform Raman spectroscopy (Hancewicz and Petty, 1995), chemiluminescence (Song and Hou, 2003) and fluorescence quenching. Therefore, the aim of this study was to develop and validate a novel High Performance Liquid Chromatography (HPLC) methodology for rapid detection and quantitation of water soluble vitamin B12 in biological fluids (plasma) which can lead to both time and cost saving. keywords: b12; hplc; sample; solution; vitamin; water cache: bjp-33108.pdf plain text: bjp-33108.txt item: #616 of 942 id: bjp-33182 author: Jawad, Muhammad; Khan, Haroon; Pervez, Samreen; Bawazeer, Saud S.; Abu-Izneid, Tareq; Saeed, Muhammad; Kamal, Mohammad A. title: Pharmacological validation of the anxiolytic, muscle relaxant and sedative like activities of Capsicum annuum in animal model date: 2017 words: 6095 flesch: 66 summary: Our extract showed similar behavior, so C. annuum extract might be worked through GABA which is similar to diazepam. Pretreatment of crude extract and n-hexane fraction elicited marked dose-dependent antianxiety-like effects in elevated plus-maze and dark and light models. keywords: annuum; control; crude; diazepam; dose; effect; extract; fraction; hexane; test cache: bjp-33182.pdf plain text: bjp-33182.txt item: #617 of 942 id: bjp-33208 author: Gopikrishnan, Venugopal; Radhakrishnan, Manickkam; Pazhanimurugan, Raasaiyah; Shanmugasundaram, Thangavel; Balagurunathan, Ramasamy title: Antimicrobial, antitubercular and antiproliferative activities of quercetin isolated from the marine Streptomyces fradiae date: 2017 words: 1087 flesch: 46 summary: Figure 1: Anti-microbial activity of quercetin against standard and MDR microbial pathogens Test bacterial pathogens % R ed uc tio n in R LU 100 80 60 40 20 0 25 µg/mL 12.5 µg/mL 6.1 µg/mL 3.1 µg/mL Concentrations M. tuberculosis H37Rv M. tuberculosis (SHRE sensitive) Anti-microbial activity of soil actinomycetes isolated from Western Ghats in Tamil Nadu, India. keywords: activity; quercetin; tuberculosis cache: bjp-33208.pdf plain text: bjp-33208.txt item: #618 of 942 id: bjp-33209 author: Sultana, Syeda Papia; Rahman, Md. Sayedur title: Dynamic online antimicrobial guideline with stewardship program: Impact on antimicrobial prescribing date: 2017 words: 4227 flesch: 37 summary: Conclusion A dynamic online platform for ASP including antimicrobial guideline might be an option for policy makers to incorporate or implement in Bangladesh in order to improve antimicrobial prescribing in teaching hospital. Coverage means proportion of diagnosis mentioned in the treatment sheer present in the guideline; Adherence means proportion of prescrip- tion, selection of which adhered/matched to the antimicrobial mentioned in BSMMU antimicrobial guideline 2015 for that diagnosis 368 Bangladesh J Pharmacol 2017; 12: 364-370 Microbiology, BSMMU and all staff of the Information Technology Cell of the University. keywords: antimicrobial; bangladesh; bsmmu; departments; guideline; intervention; medicine; pediatrics; prescribers; prescribing cache: bjp-33209.pdf plain text: bjp-33209.txt item: #619 of 942 id: bjp-33218 author: Hamid, Irfan; Janbaz, Khalid Hussain title: Ethnopharmacological basis for antispasmodic, antidiarrheal and antiemetic activities of Ceratonia siliqua pods date: 2017 words: 5282 flesch: 49 summary: Muscarinic receptor blocking activity To confirm the antispasmodic effect, rabbit jejunum was treated with 1 µM carbachol to induce contraction and C. siliqua extract was added in a cumulative fashion (1-10 mg/kg) to attain concentration-dependent spas- molytic response. So, it might be possible that the antispasmodic effect of crude extract, dichloromethane fraction and free base alkaloid fraction of C. siliqua extract was possibly mediated through blockage of muscarinic receptor M3. keywords: activity; c. siliqua; carbachol; contraction; extract; fraction; group; jejunum; pods; siliqua cache: bjp-33218.pdf plain text: bjp-33218.txt item: #620 of 942 id: bjp-33240 author: Liu, Xueying; Ran, Xiaoku; Dou, Deqiang; Cai, Decheng title: Effectiveness of Tagetes patula against chronic nonbacterial prostatitis in rat model date: 2017 words: 5272 flesch: 51 summary: Therefore, we further investigated the effects of different constitu- ents of T. patula on chronic nonbacterial prostatitis rats. Chronic nonbacterial prostatitis was induced in the model group according to the method was established as described previous (Robinette, 1988). keywords: effect; extract; group; levels; model; patula; prostate; prostatitis; rat; treatment; water cache: bjp-33240.pdf plain text: bjp-33240.txt item: #621 of 942 id: bjp-33243 author: Alamgeer, .; Ain, Qurat ul; Hasan, Umme Habiba; Asif, Hira title: Antithrombotic activity of Mentha longifolia in animal model date: 2018 words: 4543 flesch: 57 summary: Aqueous methanolic (70:30) extract produced significant (p<0.01-0.001) and dose- dependent increase in in vitro blood clotting time, bleeding time, prothrombin time and activated partial thromboplastin level with maximum effect at highest concentration. Clotting time (sec) 186.0 ± 3.6 201.6 ± 8.1ns 261.2 ± 3.0a 311.4 ± 3.5a Prothrombin time (sec) 11.2 ± 1.1 19.4 ± 1.9c 27.0 ± 2.6a 33.0 ± 1.6a Activated partial thromboplastin time (sec) 25.6 ± 1.8 42.4 ± 4.4b 54.8 ± 1.5a 65.8 ± 2.1a Results are expressed as mean ± SEM; One-way ANOVA followed by Dunnet’s t-test; Where, nsnon-significant, cp<0.1, bp<0.01 and cp<0.001 as compared to control Figure 2: Effects of aqueous methanolic extract of M. longifolia on bleeding time of rabbit. keywords: activity; aqueous; bleeding; blood; clotting; clotting time; effect; et al; extract; longifolia; prothrombin; thromboplastin; time cache: bjp-33243.pdf plain text: bjp-33243.txt item: #622 of 942 id: bjp-33313 author: Hasan, Umme Habiba; Alamgeer, . title: Antiarthritic efficacy of Clematis orientalis date: 2018 words: 5369 flesch: 55 summary: In formaldehyde induced arthritis C. orientalis appreciably and dose-dependently decreased edematous swelling all through the study Table II Effect of crude extract and different fractions of C. orientalis on paw volume in formaldehyde induced arthritis Treatment groups 2nd day 4th day 6th day 8th day 10th day Increase in paw volume (mL) Arthritic control (3 mL/kg) 1.5 ± 0.1 1.8 ± 0.0 2.0 ± 0.0 2.0 ± 0.0 2.1 ± 0.0 Piroxicam (10 mg/kg) 1.2 ± 0.1b 1.0 ± 0.1c 0.9 ± 0.1c 0.7 ± 0.0c 0.5 ± 0.0c Aqueous ethanol extract (50 mg/kg) 1.2 ± 0.1b 1.3 ± 0.1c 0.8 ± 0.1c 0.7 ± 0.1c 0.6 ± 0.0c Aqueous ethanol extract (100 mg/kg) 1.1 ± 0.1c 1.2 ± 0.0c 0.8 ± 0.0c 0.6 ± 0.0c 0.6 ± 0.0c Aqueous ethanol extract (200 mg/kg) 0.9 ± 0.0c 1.1 ± 0.0c 0.7 ± 0.0c 0.5 ± 0.0c 0.4 ± 0.0c Hexane fraction (50 mg/kg) 1.2 ± 0.1ns 1.4 ± 0.1c 1.2 ± 0.1c 1.0 ± 0.1c 0.9 ± 0.1c Hexane fraction (100 mg/kg) 1.1 ± 0.0b 1.3 ± 0.0c 1.0 ± 0.1c 0.9 ± 0.1c 0.8 ± 0.1c Hexane fraction (200 mg/kg) 1.0 ± 0.1c 1.2 ± 0.0c 0.9 ± 0.1c 0.8 ± 0.1c 0.7 ± 0.0c Butanol fraction (50 mg/kg) 1.1 ± 0.1c 1.3 ± 0.1c 1.0 ± 0.1c 0.9 ± 0.1c 0.8 ± 0.0c Butanol fraction (100 mg/kg) 0.9 ± 0.1c 1.2 ± 0.1c 0.8 ± 0.1c 0.7 ± 0.1c 0.6 ± 0.1c Butanol fraction (200 mg/kg) 0.9 ± 0.1c 1.1 ± 0.0c 0.7 ± 0.0c 0.6 ± 0.0c 0.5 ± 0.0c Aqueous fraction (50 mg/kg) 1.0 ± 0.1c 1.2 ± 0.1c 0.9 ± 0.1c 0.8 ± 0.0c 0.7 ± 0.0c Aqueous fraction (100 mg/kg) 0.9 ± 0.0c 1.1 ± 0.0c 0.8 ± 0.1c 0.7 ± 0.0c 0.7 ± 0.0c Aqueous fraction (200 mg/kg) 0.8 ± 0.0c 1.1 ± 0.1c 0.7 ± 0.0c 0.6 ± 0.0c 0.5 ± 0.0c Data is represented as mean ± SEM (n = 5) analyzed by Two-way ANOVA and p<0.05 was considered as significant as compared to arthritic control. Hexane fraction 200 mg/kg 5.1 ± 0.2c 5.8 ± 0.1c 5.5 ± 0.0c 4.9 ± 0.2c 5.0 ± 0.1c Butanol Fraction 50mg/kg 5.5 ± 0.1a 5.8 ± 0.3c 5.0 ± 0.2c 4.9 ± 0.0c 4.8 ± 0.2c Butanol fraction 100 mg/kg 4.9 ± 0.2c 5.2 ± 0.1c 4.7 ± 0.3c 4.3 ± 0.3c 4.1 ± 0.3c Butanol fraction 200 mg/kg 4.8 ± 0.1c 5.0 ± 0.1c 4.4 ± 0.1c 4.1 ± 0.1c 3.7 ± 0.1c Aqueous fraction 50 mg/kg 5.2 ± 0.2c 5.7±0.2c 4.8 ± 0.1c 4.6 ± 0.2c 4.2 ± 0.1c Aqueous fraction 100 mg/kg 4.8 ± 0.0c 5.0 ± 0.1c 4.7 ± 0.0c 4.2 ± 0.2c 3.8 ± 0.2c Aqueous fraction 200 mg 4.6 ± 0.2c 4.8 ± 0.1c 4.0 ± 0.1c 3.9 ± 0.1c 3.4 ± 0.0c keywords: 0.0c; 0.1c; arthritis; extract; fraction; orientalis cache: bjp-33313.pdf plain text: bjp-33313.txt item: #623 of 942 id: bjp-33478 author: Qadir, Muhammad Imran; Manzoor, Ayesha; Akash, Muhammad Sajid Hamid title: Potential role of medicinal plants for anti-atherosclerosis activity date: 2018 words: 5617 flesch: 53 summary: Results showed that the group that was treated with both KRG and exercise revealed more reduction of atherosclerosis than other groups (Lee et al., 2014). M in i-r ev ie w The saponins obtained from the G. pentaphyllum reduce the cholesterol level by modulation of the absorption from intestine by lowering the solubilization of micelles (Liu et al., 2016). keywords: activity; anti; atherosclerosis; cholesterol; deposition; effects; et al; extract; garlic; level; lipid; plant; rats; reduction; results; role cache: bjp-33478.pdf plain text: bjp-33478.txt item: #624 of 942 id: bjp-33520 author: Rabiei, Zahra; Naderi, Sajad; Rafieian-Kopaei, Mahmoud title: Study of antidepressant effects of grape seed oil in male mice using tail suspension and forced swim tests date: 2017 words: 4216 flesch: 50 summary: Bangladesh Journal of Pharmacology Research Article Study of antidepressant effects of grape seed oil in male mice using tail suspension and forced swim tests BJP Introduction Depression is a multifactorial, chronic, and life-threat- ening disorder with high prevalence rate worldwide. Grape seed oil is prepared by squeezing and refining of fresh grape seed and its nutritional properties are comparable to those of olive oil. keywords: grape; grape seed; mice; oil; seed; seed oil; stress; time cache: bjp-33520.pdf plain text: bjp-33520.txt item: #625 of 942 id: bjp-33552 author: Saleem, Uzma; Sabir, Shakila; Ahmad, Bashir title: Protective role of Nigella sativa in chemotherapy-induced alopecia date: 2017 words: 4971 flesch: 60 summary: Anagen Catagen Figure 4: Percentage of hair follicles in either anagen or catagen phase Figure 5: Macroscopic changes in different groups on day 35 of experiment; N. sativa oil and decoction encouraged hair growth by inducing hair follicle in the anagen phase. keywords: alopecia; chemotherapy; control; cyclophosphamide; day; decoction; disease; hair; n. sativa; oil; rat; sativa cache: bjp-33552.pdf plain text: bjp-33552.txt item: #626 of 942 id: bjp-33585 author: Salehi, Azadeh; Setorki, Mahbubeh title: Effect of Hyssopus officinalis essential oil on chronic stress-induced memory and learning impairment in male mice date: 2017 words: 5135 flesch: 54 summary: The present study investigated the effect of H. officinalis essential oil on avoidance memory in chronic stress-induced. Mice were exposed to chronic immobilization stress and were treated with H. officinalis essential oil for 21 days. keywords: anti; brain; control; control group; group; ine; memory; mice; officinalis; oil; serum; stress cache: bjp-33585.pdf plain text: bjp-33585.txt item: #627 of 942 id: bjp-33596 author: Shylaja, Gunasekaran; Sathiavelu, Arunachalam title: Cytotoxicity of endophytic fungus Chaetomium cupreum from the plant Mussaenda luteola against breast cancer cell line MCF-7 date: 2017 words: 1414 flesch: 53 summary: Phongpaichit S, Nikom J, Rungjindamai N, Sakayaroj J, Towatana NH, Rukachaisirikul V, Kirtikara K. Biological activities of extracts from endophytic fungi isolated from Garcinia plants. Torreyanic acid from the endophyte Pestalotiopsis microspora of T. taxifolia which showed more potency against many cancer cell lines by inhibiting the protein A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2017; 12: 373-375 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088; DOI: 10.3329/bjp.v12i4.33596 Letter to the Editor keywords: cancer; cell; endophytic; plant cache: bjp-33596.pdf plain text: bjp-33596.txt item: #628 of 942 id: bjp-33625 author: Lohidakshan, Krishnakumar; Rajan, Manju; Ganesh, Andhale; Paul, Mathew; Jerin, Jithu title: Pass and Swiss ADME collaborated in silico docking approach to the synthesis of certain pyrazoline spacer compounds for dihydrofolate reductase inhibition and antimalarial activity date: 2018 words: 4399 flesch: 54 summary: 1991-0088 Abstract New series of pyrazoline spacer compounds were prepared by the reaction between benzimidazole chalcones and (2-methyl-5-nitro-imidazole-1-yl)- acetic acid hydrazide by the sensible use of Michael addition. The PASS activity prediction for pyrazoline compounds given a higher value of proba- bility for antiprotozoal action (Figure 2). keywords: activity; adme; antimalarial; compounds; docking; drug; methyl-5; prediction; pyrazoline; results; silico; synthesis cache: bjp-33625.pdf plain text: bjp-33625.txt item: #629 of 942 id: bjp-33652 author: Canli, Kerem; Simsek, Ozcan; Yetgin, Ali; Altuner, Ergin Murat title: Determination of the chemical composition and antimicrobial activity of Frankenia hirsuta date: 2017 words: 3475 flesch: 47 summary: Bangladesh Journal of Pharmacology Research Article Determination of the chemical com-Determination of the chemical com-Determination of the chemical com- position and antimicrobial activity of position and antimicrobial activity of position and antimicrobial activity of Frankenia hirsutaFrankenia hirsutaFrankenia hirsuta BJP Introduction Foodborne pathogens cause critical problems all over the world. The results showed that F. hirsuta had antimicrobial activity against all of the studied micro-organisms except E. aerogenes and E. coli. keywords: acid; activity; antimicrobial; bacteria; canli; composition; extract; hirsuta cache: bjp-33652.pdf plain text: bjp-33652.txt item: #630 of 942 id: bjp-33668 author: Karakaya, Songül; Özbek, Hilal; Gözcü, Sefa; Güvenalp, Zühal; Yuca, Hafize; Duman, Hayri; Kazaz, Cavit; Kiliç, Ceyda Sibel title: α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots date: 2018 words: 4197 flesch: 60 summary: α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots 6RQJ�O�.DUDND\D���+LODO�g]EHN���6HID�*|]F����=�KDO�*�YHQDOS���+DIL]H�0.05 Ejection fraction 0.29 <0.05 Hospital stay after surgery 0.32 <0.05 Number of blood vessels corrected 0.02 >0.05 Mortality within 30 days 0.09 >0.05 Mortality within 1 year 0.12 >0.05 Bypass procedure time 0.10 >0.05 Readmission 0.09 Abstract The purpose of the present study was to assess whether pre-operative and post-operative B-type natriuretic peptide (BNP) levels could be used as the predictor of post-operative complications in Chinese patients undergoing elective surgery under general anesthesia. keywords: bnp; et al; hospital; levels; patients; study; surgery cache: bjp-33712.pdf plain text: bjp-33712.txt item: #632 of 942 id: bjp-33904 author: Sasikumar, Kandasamy; Pavithra, M.; Ghosh, Asit Ranjan title: Antibacterial activity of phenolic compounds from Terminalia arjuna against multidrug resistant E. coli isolated from meat shop date: 2017 words: 1446 flesch: 51 summary: Antibacterial activity of phenolic compounds from Ter- minalia arjuna against multidrug resistant E. coli isolated from meat shop. Bangladesh J Pharmacol 2017; 12: 371-372 372 Table II Antibiotic potential of phenolic compounds against multidrug resistant E. coli strains Concentration (µg/well) Zone of Inhibition (mm) PV3 PV8 PV31 PV32 PV34 62.5 14 13 15 12 14 125 15 15 16 14 15 250 17 17 19 19 18 500 18 18 20 20 19 mailto:cidcvit@gmail.com DatePrinted: This article was downloaded by you on: Oct 12, 2017 keywords: coli; multidrug cache: bjp-33904.pdf plain text: bjp-33904.txt item: #633 of 942 id: bjp-33908 author: Bouabdallah, Salwa; Laouini, Dhafer; Bouzouita, Nabiha; El-Bok, Safia; Sghaier, Rabiaa M.; Selmi, Sawssen; Attia, Mossadok Ben title: Separation and evaluation of natural antileishmanial potential against Leishmania major and infuntum isolated from the Tunisia strains date: 2018 words: 6417 flesch: 50 summary: As described in the introduction section, recently saponins have become a research hotspot due to their multiple and strong bioactivities, especially their cytotoxic activities on a series of tumor cell lines related to their chemical structure (Bouabdallah et al., 2015; Nath et al., 2016; Zhang et al., 2016; Zhou et al., 2017). In our last publication we have shown a strong inhibitory activity of Tunisian T. terrestris on ovary cancer cell lines (Bouabdallah et al., 2015), so in the present study we propose to investigate the antileishmanial effect on L. major and L. infuntum of T. terrestris according to, solvent extraction and the part of the plant used. keywords: activity; antileishmanial; bangladesh; cell; effect; extract; fraction; major; min; plant; saponins; terrestris; tunisia cache: bjp-33908.pdf plain text: bjp-33908.txt item: #634 of 942 id: bjp-34031 author: Chen, Anguo; Yu, Zaicheng; Zhang, Renquan; Zhao, Qihong; Ge, Jianjun title: Role of poly (ADP-ribose) polymerase-1 and NF-kappaB as potential risk factor in the development of non-small cell lung cancer in Chinese individuals date: 2018 words: 3543 flesch: 61 summary: Role of poly (ADP-ribose) polymerase-1 and NF-kappaB as potential risk factor in the development of non-small cell lung cancer in Chinese individuals $QJXR�&KHQ���=DLFKHQJ� chloroform extract> methanol extract> aqueous extract, whereas the total flavonoids contents of plant extracts had the following order: chloroform extract> methanol extract> ethyl acetate extract> aqueous extract. It is imperative to use more than one anti-oxidant test when evaluate the anti-oxidant efficacy of plant extracts because different extract possess different phyto- chemicals in different concentrations that may act through different mechanisms. keywords: acetate; activity; anti; blood; diuretic; ethyl; extract; glandulosum; methanol; plant; pressure; radical; scavenging cache: bjp-38089.pdf plain text: bjp-38089.txt item: #683 of 942 id: bjp-3809 author: Kuppusamy, Asokkumar; Varadharajan, Subhadradevi; Josey, Christy; John, Honey; Sherin, Daphne; Chirakkan, Divia; Athiyappan, Gokul title: Cardioprotective effect of Erythrina stricta leaves on isoproterenol-induced myocardial infarction in rat date: 2010 words: 2724 flesch: 51 summary: The present study concludes that E. stricta extract has a prophylactic value in myocardial infarction. The level of GSH was found to be reduced in myocardial infracted rats. keywords: extract; group; infarction; isoproterenol; myocardial; rats; stricta cache: bjp-3809.pdf plain text: bjp-3809.txt item: #684 of 942 id: bjp-38093 author: Maqbool, Sidra; Younus, Ishrat title: Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice date: 2019 words: 6569 flesch: 59 summary: In addition to this, a significant reduction in latency to first head dip, with augmentation in head dipping behavior and rearing by ethanolic extract leaves of C. laurifolius leaves at dose 200 and 400 mg/kg. The hypnotic activity of ethanolic extract leaves of C. laurifolius leaves was observed by sodium-pentobar- bital-induced hypnosis in comparison with diazepam. keywords: activity; anxiety; anxiolytic; day; dose; effect; extract; laurifolius; leaves; mice; number; test; time cache: bjp-38093.pdf plain text: bjp-38093.txt item: #685 of 942 id: bjp-38273 author: Sarah, Quazi Sahely; Misbahuddin, Mir title: Effect of Solanum melongena peel extract in the treatment of arsenic-induced Bowen’s disease date: 2018 words: 4576 flesch: 59 summary: After topical application of S. melongena peel extract containing ointment for 12 weeks, the percentage of reduction was statistically significant. This is the first study showing the effect of topical application of S. melongena peel extract in the treatment of arsenic-induced Bowen’s disease. keywords: arsenic; bowen; cancer; disease; extract; melongena; patient; peel; study; treatment cache: bjp-38273.pdf plain text: bjp-38273.txt item: #686 of 942 id: bjp-38375 author: El Gabbas, Zineb; Bezza, Kenza; Laadraoui, Jawad; Makbal, Rachida; Aboufatima, Rachida; Chait, abderrahman title: Salvia officinalis induces antidepressant-like effect, anxiolytic activity and learning improvement in hippocampal lesioned and intact adult rats date: 2018 words: 8082 flesch: 57 summary: Systematic and mechanistic studies of the effects of S. officinalis extracts have revealed multiple activities potentially relevant to brain function, and some reports showed that ethanolic extract of S. officinalis potentiates the memory retention and interacts with muscarinic and nicotinic cholinergic systems involved in the memory retention process (Eidi et al., 2006). DPPH Free radical-scavenging activity The total anti-oxidant capacity measures the free radical scavenging capacity of S. officinalis extract. keywords: acid; activity; antidepressant; control; effect; extract; group; learning; methanolic; min; officinalis; pharmacol; rats; sage; test cache: bjp-38375.pdf plain text: bjp-38375.txt item: #687 of 942 id: bjp-38421 author: Anny, Fatema Chowdhury; Misbahuddin, Mir title: Effect of cock’s comb extract in the treatment of palmar arsenical keratosis date: 2019 words: 3733 flesch: 58 summary: A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmer arsenical keratosis patients, Bangladesh J Pharmacol. Data collection procedures After taking informed written consent, the detailed history was taken by interviewing and clinical examina- tions were done mainly based on arsenical keratosis of the palm of the participants and recorded in the data collection sheet. keywords: bangladesh; cock; comb; extract; keratosis; palmar; treatment; water cache: bjp-38421.pdf plain text: bjp-38421.txt item: #688 of 942 id: bjp-38444 author: Ötün, Barış; Yücel, Ufuk Mercan title: Wound healing effect of different extracts of Centaurea pterocaula date: 2019 words: 4945 flesch: 57 summary: Methanol extract group: The pomade prepared with methanol extract (about 0.5 g) was administered to the wound area in the back of rats. While there was no statistically significant difference between methanol extract group and ethyl acetate extract group on day 10, the difference between these two groups and other groups was statistically significant. keywords: acetate; anti; area; centaurea; day; effect; extract; extract group; group; healing; hexane; wound cache: bjp-38444.pdf plain text: bjp-38444.txt item: #689 of 942 id: bjp-38593 author: Shylaja, Gunasekaran; Sasikumar, Kandasamy; Sathiavelu, Arunachalam title: Antimycobacterial and anti-oxidant potential of the bioactive metabolite isolated from the endophytic fungus Daldinia eschscholtzii date: 2018 words: 1730 flesch: 55 summary: In this study, endophytic fungi Daldinia eschscholtzii was isolated from the ornamental plant Mussaenda luteola (Family: Rubiaceae) since this plant was reported with many therapeutic properties like cytotoxicity, anti- inflammatory, antimicrobial and many others with predominant phytochemicals such as iridoids, triter- penes and phenols (Shylaja and Sathiavelu, 2017). The various concentration of isolated compound 1 was tested for antimycobacterial potential against Mycobacterium tuberculosis H37Rv strain. keywords: bangladesh; compound; endophytic; eschscholtzii; fungus cache: bjp-38593.pdf plain text: bjp-38593.txt item: #690 of 942 id: bjp-38612 author: Deepika, Subramanyam; Selvaraj, Immanuel; Anbalagan, Moorthy title: Phytochemical characterization and cancer cell line cytotoxicity of Clitoria ternatea date: 2018 words: 1920 flesch: 48 summary: I Identification of phytochemicals from Clitoria ternatea extracts by various standard tests Petroleum ether Chloroform Ethyl acetate Methanol Aqueous Leaf Fruit Leaf Fruit Leaf Fruit Leaf Fruit Leaf Fruit Carbohydrate Fehling's test + + + + + + + + + + Molisch's test - + + + - - + + + - Protein Ninhydrin - + - - - + - + - + Biuret - - + + - - - - - + Phenols Ferric chloride - - - - + - - - - + Lead acetate - + - - - - - + + + Flavonoid - + + + + - - + + - Glycoside Salkowski's test + + - - + + - - - - Keller Kilani test - + - + - + + + + + Steroid - - + - - + - + + + Terpenoid - + - - - - - + - - Alkaloid Mayer's - + - + - - + - + + Wagner's - - - + - - - + - + Hager's + - - + - - - + + + “+” means present; “-” means absent Jasco V-670 (Japan) spectrophotometer to detect a specific wavelength of the available phytochemicals (data not shown). Bangladesh Journal of Pharmacology Volume: 13; Number 4; Year 2018 Cite this article as: Deepika S, Selvaraj CI, Anbalagan M. Phytochemical characterization and cancer cell line cyto- toxicity of Clitoria ternatea. keywords: cancer; clitoria; extract; fruit; leaf; ternatea cache: bjp-38612.pdf plain text: bjp-38612.txt item: #691 of 942 id: bjp-38725 author: Xu, Weiyuan; Miao, Shenglong; Feng, Yuchen title: Ludartin exhibits therapeutic effect on spinal cord injury through inhibition of apoptosis and inflammation date: 2019 words: 5059 flesch: 53 summary: Ludartin treatment of spinal cord injury rats improves locomotion by inhibiting inflammatory cytokine expression and preventing cell apoptosis. The current study investigates the effect of ludartin on expression of oxidative stress inducing factors, inflammatory cytokines and onset of apoptosis in spinal cord tissues of spinal cord injury rats. keywords: control; cord; cord injury; expression; injury; injury rats; level; ludartin; rats; spinal; spinal cord; treatment cache: bjp-38725.pdf plain text: bjp-38725.txt item: #692 of 942 id: bjp-38807 author: Dong, Kun; Wang, Guan; Wang, Zeng Liang; Wang, Xueyan title: Efficacy and safety of regorafenib versus dinutuximab with chemotherapy in Chinese children with neuroblastoma date: 2019 words: 2548 flesch: 49 summary: Cao J, Zhang J, Peng W. A Phase I study of safety and phar- macokinetics of fruquintinib, a novel selective inhibitor of vascular endothelial growth factor receptor-1, -2, and -3 tyrosine kinases in Chinese patients with advanced solid tumors. Lacouture ME, Reilly LM, Gerami P. Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib. keywords: chemotherapy; dinutuximab; neuroblastoma; patients; regorafenib; safety cache: bjp-38807.pdf plain text: bjp-38807.txt item: #693 of 942 id: bjp-38870 author: Bouabid, Khadija; Lamchouri, Fatima; Toufik, Hamid; Boulfia, Mohamed; Senhaji, Souad; Faouzi, My El Abbes title: In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera date: 2019 words: 5073 flesch: 53 summary: Indeed, the creatinine level became 2.3 ± 0.6 mg/L after treatment of diabetic mice by aqueous macerate, and 3.2 ± 0.6 mg/L after treatment with macerated methanol, and 3.7 ± 0.2 mg/L after treatment with metformin with differences statistically insigni- ficant between these last three groups and significant compared to the tested mice, non-diabetic mice and untreated diabetic mice (Figure 2). The administration of the aqueous macerate of A. gummifera decreased cholesterolemia and serum triglyceride levels in diabetic mice with statistically significant differences compared to untreated diabetic mice and non-diabetic mice in the range of 1.2 ± 0.1 and 0.9 ± 0.1 g/L. Similarly, metformin decreased the lipid profile in diabetic mice with respective cholesterol and triglyceride values of 1.1 ± 0.1 and 0.9 ± 01 keywords: aqueous; blood; diabetes; diabetic; extracts; glucose; gummifera; macerate; methanol; mice; treatment cache: bjp-38870.pdf plain text: bjp-38870.txt item: #694 of 942 id: bjp-38871 author: Ding, Ruru; Zhu, Ziying; Teng, Mengting; Ma, Lin; Hu, Jiaying; Hu, Jiangbiao; Zhang, Peng title: A potential estrogen receptor inhibitor compound 34 induces apoptosis via ROS-independent intrinsic apoptosis in MCF-7 cells date: 2019 words: 5251 flesch: 54 summary: NS means no statistical significance, p>0.05 Figure 6: Compound 34 decreased MCF-7 cells migration (A) Images of the wound healing ability of MCF-7 cells treated with compound 34 at 0.6 µg/mL for 6 and 24 hours. Furthermore, this is the first time we demonstrated that compound 34 can induce MCF-7 cell apoptosis via ROS-independent intrinsic apoptosis pathway and interacting with ERα. keywords: apoptosis; breast; cancer; cells; compound; estrogen; figure; hours; mcf-7; mcf-7 cells; membrane; potential; receptor; ros cache: bjp-38871.pdf plain text: bjp-38871.txt item: #695 of 942 id: bjp-39034 author: Pyo, Jae Sung; Kim, Hyung Hoi; Kim, Kang Min; Kang, Jae Seon title: Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract date: 2019 words: 3940 flesch: 48 summary: Clinical evaluations of dry eye After 2 weeks of oral administration of ginseng extract, fluorescein staining was carried out for clinical evaluations on corneal surface of dry eye mouse (Figure Te ar fl ow (m m /b od y w ei gh t) Bangladesh Journal of Pharmacology Research Article Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract BJP Introduction Dry eye syndrome (keratoconjunctivitis sicca) is a mul- tifactorial disease of ocular surface accompanying visual disturbance, hyperemia, photophobia and ocular discomfort (Lemp et al., 2007). keywords: cells; compound; control; dry; extract; eye; ginseng; group; kim; syndrome cache: bjp-39034.pdf plain text: bjp-39034.txt item: #696 of 942 id: bjp-39254 author: Salazar-Gómez, Anuar; Vargas-Díaz, María Elena; Garduño-Siciliano, Leticia title: Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice date: 2019 words: 3911 flesch: 52 summary: The animals were divided into five groups, comprising a minimum of seven animals in each group as follows: control: Normal mice received only water; diabetic: Diabetic mice received only water; Diabetic mice treated with T. angustifolia aqueous extract (50, 100 and 200 mg/kg/day). I Effect of T. angustifolia aqueous extract on serum lipid profile in alloxan-induced diabetic mice Total cholesterol (mmol/L) LDL (mmol/L) HDL (mmol/L) keywords: alloxan; angustifolia; aqueous; blood; diabetes; diabetic; effect; extract; mice cache: bjp-39254.pdf plain text: bjp-39254.txt item: #697 of 942 id: bjp-39847 author: Khan, Rahmat; Ahmad, Wasim; Ahmed, Mushtaq title: Stellaria media attenuates the hyperglycemia and hyperlipidemia in alloxan-induced diabetic rat date: 2019 words: 5097 flesch: 54 summary: Administration of S. media remarkably improved hemoglobin (+20.1%), and decreased HbA1c (−48.4%) when compared to diabetic control rats. These results were observed from first to fourth week of the study period in comparison to diabetic control rats. keywords: activity; alloxan; blood; control; diabetes; diabetic; extract; glucose; media; plant; rats cache: bjp-39847.pdf plain text: bjp-39847.txt item: #698 of 942 id: bjp-39890 author: Chandrasekaran, Priyadharshini; Ravindran, Sriram; Boovarahan, Sri Rahavi; Kurian, Gino A. title: Hydrogen sulfide-mediated cardioprotection against ischemia reperfusion is linked to KATP channel for mitochondrial preservation but not for its distinct preference on interfibrillar mitochondria date: 2019 words: 5904 flesch: 30 summary: Isolated rat hearts were treated with mitochondrial KATP channel closer glibenclamide (10 μM)/opener diazoxide (0.8 mM) via Langendorff perfusion apparatus before ischemia-reperfusion. This was well in agreement with previous work by Pomerantz et al, who showed tran- sient opening of mitochondrial KATP channel with diazoxide provided protection to human atrial trabe- culae against ischemia-reperfusion injury and a loss of cardioprotection was observed when diazoxide treat- ment was clubbed with ischemic preconditioning, due to the continuous opening of the potassium channel (Pomerantz et al., 2000). keywords: channel; diazoxide; gli; heart; hipc; hydrogen; injury; ischemia; katp; min; mitochondria; normal; reperfusion; subsarcolemmal; sulfide cache: bjp-39890.pdf plain text: bjp-39890.txt item: #699 of 942 id: bjp-39927 author: Abbasy, Asma Akter; Misbahuddin, Mir title: Involving postgraduate medical students in pharmacology practical classes by e-learning date: 2019 words: 4360 flesch: 58 summary: Virtual classes were conducted among the postgraduate MD students (n=26) of this department. To know the existing procedural knowledge pre-test was taken before the classes and to evaluate the effectiveness of virtual class, a post-test was carried out seven days later. keywords: bangladesh; class; face; learning; medical; online; pharmacology; students; study; teaching; test; virtual cache: bjp-39927.pdf plain text: bjp-39927.txt item: #700 of 942 id: bjp-39992 author: Rajasekaran, Muthiah title: Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat date: 2019 words: 4863 flesch: 49 summary: CPE treatment, however, showed significant protection against doxo- rubicin toxicity as evident from non-significant change of anti-oxidant enzymes when compared to the control Table I Serum markers of kidney function in different treatment groups Experimental groups Albumin (g/dL) Urea (U/L) Glutathione-S Table II Shows the level of lipid peroxides, glutathione and anti-oxidant enzymes in the kidney Treatment groups Lipid pe- roxidation Reduced glutathione Glutathione peroxidase Glutathione- S-transferase Catalase Superoxide dismutase Control 16.6 ± 1.5 26.1 ± 1.4 19.0 ± 1.2 7.2 ± 1.0 18.0 ± 1.8 26.0 ± 1.8 Doxorubicin 38.0 ± 2.0a 14.7 ± 1.8a 9.0 ± 1.8a 2.5 ± 1.6 b 7.4 ± 1.4a 12.1 ± 1.4a Doxorubicin + C. pictus extract (200 mg/kg) 21.5 ± 1.5 18.2 ± 1.3b 12.1 ± 1.0b 5.3 ± 1.3 11.9 ± keywords: anti; doxorubicin; effect; extract; glutathione; kidney; pharmacol; pictus; rats; tissue cache: bjp-39992.pdf plain text: bjp-39992.txt item: #701 of 942 id: bjp-40098 author: Qureshi, Zainab; Khan, Taous; Shah, Abdul Jabbar; Wahid, Fazli title: Solanum incanum extract enhances wound healing and tissue regeneration in burn mice model date: 2019 words: 3339 flesch: 54 summary: Despite the discovery of various antibacterial and antiseptic agents, burn wound healing is still a challenging health issue in modern medicine. Accepted: 28 April 2019 Available Online: 21 May 2019 DOI: 10.3329/bjp.v14i2.40098 Cite this article: Qureshi Z, Khan T, Shah AJ, Wahid F. Solanum incanum extract enhances wound healing and tissue regenera- tion in burn mice model. keywords: burn; control; day; group; healing; incanum; tissue; treatment; wound cache: bjp-40098.pdf plain text: bjp-40098.txt item: #702 of 942 id: bjp-4019 author: Bhuiyan, Mohammad Nazrul Islam; Akter, Farhana; Chowdhury, Jasim Uddin; Begum, Jaripa title: Chemical constituents of essential oils from aerial parts of Adenosma capitatum and Limnophila aromatica date: 2010 words: 1996 flesch: 58 summary: Regarding A. capitatum and L. aromatica, essential oils, no work is available in our country. So, the work has been undertaken to study the chemical components of essential oils obtained from aerial parts of A. capitatum and L. aromatica grown in Bangladesh respectively. keywords: aromatica; bangladesh; capitatum; constituents; limonene; oils cache: bjp-4019.pdf plain text: bjp-4019.txt item: #703 of 942 id: bjp-40292 author: Shah, Muhammad Abdur Rehman; Khan, Rahmat Ali; Ahmed, Mushtaq title: Phytochemical analysis, cytotoxic, antioxidant and anti-diabetic activities of the aerial parts of Sorghum halepense date: 2019 words: 5054 flesch: 47 summary: The anti- oxidant characteristics of S. halepense methanolic extract and its different fractions were concentration- dependent. Hydrogen peroxide scavenging (H2O2) capacity Table I Phytochemical screening of S. halepense methanolic extract and its chloroform and aqueous fractions Crude methanolic extract and its fractions Phytochemical Tests Aqueous Methanol Chloroform n-Hexane Saponins Alkaline reagent test - - - - Flavonoids Ferric chlorides test + + - + Glycosides Fehling test + + + - steroids Millon’s test + + + - Reducing sugar Benedict’s test + + + - Tannins Ferric chloride test + + + - Gums Molish’s reagent test - - - - Table II %Lethality of brine shrimps caused by crude methanolic extract and its various fractions of S. halepense Concentration (µg/mL) %Lethality of crude methanolic extract and its fractions Methanolic extract Chloroform Aqueous n-Hexane Control 100 40.7 ± 1.3 30.6 ± 1.2 20.3 ± 1.5 10.2 ± 1.7 00 ± 00 250 50.8 ± 1.5 30.8 ± 1.1 30.9 ± 1.3 10.3 ± 1.6 00 ± 00 500 70.6 ± 1.7 50.4 ± 1.8 30.1 ± 1.5 30.7 ± 1.9 10.2 ± 1.1 1000 80.7 ± 1.3 60.3 ± 1.1 50.4 ± 1.6 40.6 ± 1.5 00 ± 00 keywords: absorbance; activities; activity; antioxidant; chloroform; dpph; extract; fractions; halepense; methanolic; methanolic extract; phenolic; scavenging cache: bjp-40292.pdf plain text: bjp-40292.txt item: #704 of 942 id: bjp-40537 author: Bezza, Kenza; Gabbas, Zineb El; Laadraoui, Jawad; Laaradia, Mehdi Ait; Oufquir, Sara; Chait, Abderrahman title: Ameliorative potential of Anacyclus pyrethrum extract in generalized seizures in rat: Possible cholinergic mediated mechanism date: 2019 words: 5374 flesch: 56 summary: The high-performance liquid chromatography (Knauer) equipped with a pump (K-1001) and a PDA detector (200-700 UV-Vis) was used to separate and characterize compounds present in A. pyrethrum extract. In addition to anticonvul- sant studies, A. pyrethrum extract was also screened for its acute and subchronic toxicity; it did not produce any behavioral abnormalities or mortality. keywords: activity; alkylamides; anticonvulsant; atropine; epilepsy; et al; ethanol; ethanol extract; extract; mice; pilocarpine; pyrethrum; seizures cache: bjp-40537.pdf plain text: bjp-40537.txt item: #705 of 942 id: bjp-40803 author: Haq, Israr ul; Aslam, Muhammad; Ahmed, Hammad; Sultana, Nuzhat title: Antidepressant-like activity of hydroalcoholic extract of Agaricus blazei in stressed and unstressed mice date: 2019 words: 5605 flesch: 52 summary: The immobility time in both unstressed and stressed mice was significantly decreased (from 166.6 ± 4.4 sec to 141.2 ± 3.0 sec in unstressed mice and 198.0 ± 3.1 sec to 148.0 ± 3.1 sec in stressed mice using tail suspension test) by treatment with A. blazei. The plasma nitrite levels of stressed mice were elevated to 23.2 ± 3.9 µg/mL when compared with the vehicle- treated unstressed mice having the levels of 17.0 ± 2.2 µg/mL. The plasma nitrite levels of the stressed mice treated with the extract at the dose of 273 mg/kg and 819 mg/kg were significantly reduced to 14.0 ± 2.2 µg/ mL and 7.0 ± 0.9 µg/mL respectively. keywords: activity; antidepressant; blazei; effect; extract; group; mice; p.o.+; stress; test cache: bjp-40803.pdf plain text: bjp-40803.txt item: #706 of 942 id: bjp-40923 author: Sadrati, Nouari; Zerroug, Amina; Demirel, Rasime; Bakli, Sabrina; Harzallah, Daoud title: Antimicrobial activity of secondary metabolites produced by Aspergillus neobridgeri isolated from Pistacia lentiscus against multi-drug resistant bacteria date: 2020 words: 9700 flesch: 52 summary: Several studies have shown the ability of different species of endophytic fungi to inhibit pathogenic micro- organisms, for example; Aspergillus terreus and Asper- gillus tubingensis (Yadav et al., 2016), Diaporthe terebin- thifolii LGMF907 (de Medeiros et al., 2018), Phomopsis prunorum (Qu et al., 2020), P. griseofulvum TPL25 (Luo et al., 2015), Alternaria GFAV15 Endophytic fungi of the plant P. lentiscus are not yet studied for their antimicrobial activity. keywords: acetate; activity; agar; antibacterial; antimicrobial; aspergillus; atcc; aureus; bacteria; bangladesh; endophytic; et al; ethyl; extract; fungi; fungus; gram; medium; metabolites; mic; pharmacol; plant; plr9 cache: bjp-40923.pdf plain text: bjp-40923.txt item: #707 of 942 id: bjp-40977 author: Dmitry, Pozdnyakov I.; Syranusch, Nygaryan A.; Andrey, Voronkov V.; Sosnovskaya, Anastasya; Elisaveta, Cherechkova I. title: Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat date: 2019 words: 4813 flesch: 32 summary: In addition, the intro- duction of the studied drugs reduced the intensity of caspase-dependent and caspase-independent apoptosis reactions, which, together with the restoration of mitochondrial respiratory function, contributed to the decrease in the size of the necrosis zone of the brain. Bangladesh Journal of Pharmacology Research Article Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscer- ate improve mitochondrial function under condition of cerebral ischemia in rat BJP R es pi ra tio n (p pm ) ATP-generating capacity Maximum breathing rate Respiratory capacity 10 8 6 4 2 0 PO NC Acetylcysteine Choline alphoscerate Ethylmethylhydroxypyridine succinate a b b b a b b b a b b b R es pi ra tio n (p pm ) keywords: acetylcysteine; apoptosis; atp; b b; choline; control; ethylmethylhydroxypyridine; function; mitochondrial; p<0.05; rats; succinate; times cache: bjp-40977.pdf plain text: bjp-40977.txt item: #708 of 942 id: bjp-41246 author: Mawahib, Cheribet; Nabila, Zaabat; Nabila, Souilah; Chawki, Bensouici; Salah, Akkal title: LC-MS analysis, antioxidant and alpha-glucosidase inhibitory activities of Centaurea papposa extracts date: 2019 words: 4438 flesch: 52 summary: Analysis of results The results were given as 0.5 (μg/mL) which corresponding to concentration indicating 50% of absorbance intensity and results were compared with those of standards BHT and BHA. References Apak et al., 2004; Rubio et al., 2016 Bangladesh J Pharmacol 2019; 14: 159-165 161 Results Identification and quantification of contents Following the LC-MS results, phenolic acid contents in C. papposa extracts were higher than their of flavonoid contents (Table I). LC-MS analysis revealed the presence of 21 compounds among which 13 were phenolic acids, 6 flavonoids, 1 phenolic aldehyde and 1 benzo- pyrone. keywords: acetate; acid; activity; antioxidant; extract; glucosidase; ni ni; phenolic cache: bjp-41246.pdf plain text: bjp-41246.txt item: #709 of 942 id: bjp-41403 author: Sasikumar, Kandasamy; Ghosh, Asit Ranjan title: Brine shrimp cytotoxicity potential of alpha-mangostin and dulxanthone D from Garcinia mangostana date: 2019 words: 1145 flesch: 57 summary: In another report, the methanolic and ethyl acetate extract of α-mangosteen pericarp exhibited significant brine shrimp cytotoxicity with LC50 values of 153.88 and 161.75 µg/mL respec- tively after 24 hours (Ngawhirunpat et al., 2010). Kandasamy Sasikumar and Asit Ranjan Ghosh Department of Integrative Biology, School of Biosciences and Technology, VIT University, Vellore, India Corresponding author: email: asitranjanghosh@vit.ac.in References Apu A, Muhit M, Tareq S, Pathan A, Jamaluddin A, Ahmed M. Antimicrobial activity and brine shrimp lethality bioassay of the leaves extract of Dillenia indica Linn. keywords: brine; cytotoxicity; mangostana; shrimp cache: bjp-41403.pdf plain text: bjp-41403.txt item: #710 of 942 id: bjp-41472 author: Kumari, Komal Arvind; Dagha, Romil Champak; Gawali, Poonam Gautam; Jadhav, Bhaskar Laxman title: Anti-inflammatory effect of Actinia tenebrosa date: 2019 words: 1610 flesch: 58 summary: The peptides from nematocyst of sea anemones are reported to show anti-inflammatory activity. Different species of sea anemone are reported to exhibit antitumor activity, anti-parasitic activity, antimicrobial activity (Thangaraj et al., 2011), analgesic activity (An- dreev et al., 2008), antiviral activity, anti-hypersensiti- vity activity (Driscoll et al., 1989), autoimmune activity (Diochot et al, 2004) and anti-inflammatory activity (Sintsova et al, 2015) from their nematocysts. keywords: activity; anemone; sea; tenebrosa cache: bjp-41472.pdf plain text: bjp-41472.txt item: #711 of 942 id: bjp-41543 author: Pandey, Ajit Kumar title: Anticonvulsant activity of novel Schiff bases of thiadiazole derivatives date: 2019 words: 1308 flesch: 60 summary: Anticonvulsant activity of novel Schiff bases of thiadiazole derivatives. Anticonvulsant activity of novel Schiff bases of thiadiazole derivatives Sir, Heterocyclic compounds containing Schiff bases have been explored which played an important role in heterocyclic chemistry. keywords: activity; compounds; thiadiazole; yes cache: bjp-41543.pdf plain text: bjp-41543.txt item: #712 of 942 id: bjp-41545 author: Krishnan, Manigandan; Dey, Debasish Kumar; Sharma, Chanchal; Kang, Sun Chul title: Antibacterial activity of Weissella confusa by disc diffusion method date: 2019 words: 2641 flesch: 48 summary: Figure 1: The antibacterial effect of cell-free culture supernatant was evaluated by disc diffusion method and compared with ampicillin on LB agar against E. coli 0157: H7. As depicted in Figure 3, live bacterial cells appeared in green color due to acridine orange staining, whereas dead cells appeared in red color due to the loss in membrane integrity of E. coli 0157: H7 cells. keywords: cell; coli; culture; disc; supernatant cache: bjp-41545.pdf plain text: bjp-41545.txt item: #713 of 942 id: bjp-41598 author: Bai, Xuelian; Yu, Ronglu; Li, Mingzhu; Zhang, Huawei title: Antimicrobial assay of endophytic fungi from Rumex madaio and chemical study of strain R1 date: 2019 words: 4674 flesch: 51 summary: In order to search more antimicrobial natural products for new drug discovery, bioassay and chemical investigation of endophytic strains from Rumex madaio were carried out. As part of an ongoing effort to characterize medicinal plant-derived endophytes and their functional metabolites (Zhang et al., 2012; Zhang et al., 2016), isolation of endophytic strains from R. madaio and evaluation of antimicrobial effects of their culture extracts were carried out in this study as well as chemical investigation. keywords: activity; antimicrobial; aureus; compounds; et al; fungi; strains; zhang cache: bjp-41598.pdf plain text: bjp-41598.txt item: #714 of 942 id: bjp-41777 author: Ali, Muhammad Zeeshan; Mehmood, Malik Hassan; Saleem, Muhammad; Gilani, Anwar-ul-Hassan title: Pharmacological studies on the laxative effects of Fagonia indica on rodents date: 2019 words: 5328 flesch: 52 summary: In loperamide-induced constipation mice, F. indica (27.3 and 34.6%) and ursolic acid (15 and 28%) also displayed laxative effects at the aforementioned doses. The remaining groups received the pre-treatment of atropine (10 mg/kg, intra- peritoneal) and the same doses of carbachol, crude extract of F. indica and ursolic acid were administered for the reassessment of laxative effect (Mehmood et al., 2014). keywords: acid; atropine; effects; extract; fraction; ileum; indica; mice cache: bjp-41777.pdf plain text: bjp-41777.txt item: #715 of 942 id: bjp-42052 author: Pan, Yajing; Zhang, Lu; Liu, Tonghua; Wu, Lili title: Effects of shenkang injection on renal angiogenesis in mice with unilateral ureteral obstruction date: 2020 words: 4356 flesch: 48 summary: And compared to unilateral ureteral obstruction mice, deposition of renal collagen fibers decreased in mice of losartan and shenkang injection (7.8, 3.9 and 1.95 g/kg) groups. Effects of shenkang injection on VEGF and VEGFR2 As shown by the extent of dyeing and average optical density of positive areas in Figure 5 (A, B), compared to sham mice, expression of VEGF decreased significantly in unilateral ureteral obstruction mice (p<0.01). keywords: angiogenesis; effects; fibrosis; group; kidney; means; mice; obstruction; renal; sham; shenkang injection; ski; vegf cache: bjp-42052.pdf plain text: bjp-42052.txt item: #716 of 942 id: bjp-42098 author: Deivasigamani, Malarvizhi; Chandrasekar, Ajay Kasivishwanathan; Muthusami, Sridhar; Kanniappan, Gopalakrishnan Velliyur; Lakshmanan, Hariprasath title: Zaleya decandra exerts anti-cancer activity in HCT-116 cancer cells by impairing mitochondrial activity date: 2019 words: 3990 flesch: 47 summary: The increase in the generation of ROS in Z. decandra treated cells indicate that the phytoconstituents present in the extract alone or in combination could have targeted NAPDH oxidase while exerting anti-proliferative effects. D C F Fl uo re sc en ce (% o f c on tro l) 300 250 200 150 100 50 0 Figure 3: Permeability in Z. decandra-treated cells (B) when compared with control cells (A) using rhodamine-123 dye Control 100 µg/mL § A B C A B Bangladesh J Pharmacol 2019; 14: 174-180 177 find out the cellular mechanisms behind the increased ROS levels in Z. decandra treated cells. keywords: activity; cancer; cells; decandra; extract; generation; hct-116; mtt; ros; step cache: bjp-42098.pdf plain text: bjp-42098.txt item: #717 of 942 id: bjp-42320 author: Mahaboob Batcha, Arisha Taj; Wadhwani, Ashish; Subramaniam, Gowri title: In vitro antiviral activity of BanLec against herpes simplex viruses type 1 and 2 date: 2020 words: 4962 flesch: 54 summary: Discussion From the current findings, the BanLec inhibits the HSV replication of virus infected cells by evaluating the cytopathogenic effect. The least concentration of lectin causes visible agglutination in blood cells A and B are 0.4 µg/mL followed by the least concentration of agglutination in group AB and O are 0.8 µg/mL and 1.6 µg/mL respectively. keywords: activity; antiviral; assay; banlec; cell; concentration; effect; hsv-1; inhibition; lectin; vero; virus cache: bjp-42320.pdf plain text: bjp-42320.txt item: #718 of 942 id: bjp-42373 author: Semerci, Alican Bahadir; İnceçayır, Dilek; Mammadova, Vusale; Hoş, Ayşegül; Tunç, Kenan title: Antimicrobial activities of Allium staticiforme and Allium subhirsutum date: 2020 words: 3411 flesch: 57 summary: Discrepancies in extract activities might be attributed to the joint influences of both genetic factors as well as the growing conditions. Recent studies on several plants such as Duranta erecta (Donkor et al., 2019), Frankenia hirsute (Canli et al., 2017), Pinus coulteri (Merah et al., 2018), Syzygium cumini (Oliveira et al., 2007), Plectranthus glandulosis (Egwaikhide et al., 2007), Warburgia ugandensis (Okello and Kang, 2019) show antimicrobial activities. keywords: activities; activity; allium; bulb; extract; staticiforme; subhirsutum cache: bjp-42373.pdf plain text: bjp-42373.txt item: #719 of 942 id: bjp-42414 author: Kim, Dang Dinh; Nguyet, Vu Thi; Anh, Ha Xuan; Trang, Nguyen Thi Thu; Chuyen, Nguyen Hong; Huong, Le Mai; Ha, Tran Thi Hong; Ho, Do Hai; Dat, Nguyen Tien title: Cytotoxic phenolic constituents from the leaves of Ehretia asperula date: 2019 words: 1482 flesch: 60 summary: Fraction F3 was subjected to fractionation over silica gel column, eluted with dichloromethane-acetone (10/1, v/v) to give three subfractions F3.1-F3.3. Subfraction F3.1 was separated using silica gel column and further purified with C18 column to yield methyl rosmarinate (6) (3.2 mg), oresbiusin B (7) (8.1 mg) and dimethyl lithospermate (8) (100 mg). keywords: column; ehretia; vietnam cache: bjp-42414.pdf plain text: bjp-42414.txt item: #720 of 942 id: bjp-42499 author: Kaur, Jaspreet; Bhatia, Manisha; Nain, Parminder title: Antidepressant activity of Citrus limetta leaves in mice using battery of behavior models modulating via serotonergic systems  date: 2019 words: 4459 flesch: 53 summary: Abstract The methanolic extract of Citrus limetta leaves was estimated in the present study for antidepressant activity. Antidepressant activity of Citrus limetta leaves in mice using battery of behavior models modulating via serotonergic systems Jaspreet Kaur, Manisha Bhatia and Parminder Nain M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (Haryana) 133207, India. keywords: activity; antidepressant; citrus; extract; immobility; limetta; mice; min; test cache: bjp-42499.pdf plain text: bjp-42499.txt item: #721 of 942 id: bjp-42657 author: Keekan, Kishor Kumar; Padmaraj, Sunil Rao title: Improved mass screening of medicinal plants for antibacterial activity by Leaf Disc antibacterial assay date: 2019 words: 2749 flesch: 54 summary: Similarly, leaf discs were also used (Case, 2001; Ndi 2007) to determine the antibacterial properties of plants. a) Steaming: both the surface [i.e., astomatous (adaxial) and stomatous (abaxial)] of leaf disc (2.5 min on each side) on a sterile stainless steel mesh, b) keywords: assay; disc; leaf; method; plants; screening; solvent cache: bjp-42657.pdf plain text: bjp-42657.txt item: #722 of 942 id: bjp-4310 author: Balamurugan, Gunasekaran; Muralidharan, Palayan title: Antiobesity effect of Bauhinia variegata bark extract on female rats fed on hypercaloric diet date: 2010 words: 3559 flesch: 56 summary: Treatment with MEBV (200 and 400 mg/kg body weight) exhibited a insigni- ficant decrease in body weight of the animals in comparison with Group II animals. Group II animals fed on hypercaloric diet exhibited a non- significant rise in body weight between day 1 and 40 as compared to Group I animals. keywords: animals; body; cholesterol; effect; extract; group; obesity; rats; variegata; weight cache: bjp-4310.pdf plain text: bjp-4310.txt item: #723 of 942 id: bjp-43150 author: Ahmed, Wasim title: Effect of Garcinia indica against brain ischemic reperfusion in rat model date: 2020 words: 1382 flesch: 51 summary: Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices. Bangladesh Journal of Pharmacology Volume: 15; Number 1; Year 2020 Cite this article as: Ahmad W. Effect of Garcinia indica against brain ischemic reperfusion in rat model. keywords: glucose; indica; oxygen; reperfusion; slices cache: bjp-43150.pdf plain text: bjp-43150.txt item: #724 of 942 id: bjp-43235 author: Rabbi, Fazle; Zada, Amir; Nisar, Amna title: Larvicidal, leishmanicidal, insecticidal and anthelmintic effects of Sterculia diversifolia stem bark and leaf date: 2020 words: 4987 flesch: 55 summary: Insecticidal activity The crude methanolic extracts (stem bark and leaf) and their various fractions were studied for insecticidal activity against Tribolium castaneum, Rhyzopertha domi- nica and Callosobruchus analis. Insecticidal activity The insecticidal activity of crude methanolic extract and its fractions were studied against R. dominica, T. casta- neum and C. analis. keywords: activity; bark; ethyl; extract; fraction; insecticidal; leaf; methanolic; stem; stem bark cache: bjp-43235.pdf plain text: bjp-43235.txt item: #725 of 942 id: bjp-43446 author: Banerjee, Amartya; Mumtaz, Sayeed Mohammed Firdous title: In vitro antimutagenic activity of Ipomoea staphylina date: 2020 words: 1885 flesch: 55 summary: In vitro antimutagenic activity of Ipomoea staphylina Sir, The study of antimutagenic activity gives information which discovers the possibilities for combating the genotoxic risk of mutagens. Thus, I. staphylina possesses antimutagenic activity against 2- nitrofluorene induced base-pair mutation. keywords: extract; plate; staphylina cache: bjp-43446.pdf plain text: bjp-43446.txt item: #726 of 942 id: bjp-43513 author: Zhang, Qiong; Zhong, Liangjun; Chen, Xing; Wang, Jintao title: Berberine hydrochloride inhibits inflammatory response via regulating the miRNA-140-5p/TLR4/NF-κB signaling pathway in oral lichen planus date: 2020 words: 6562 flesch: 53 summary: Therefore, it can be considered that the TLR4/NF-κB signaling pathway plays an important role in the progression of oral lichen planus, and that this can be used as a target to inhibit the expression of inflammatory mediators in the course of oral lichen planus, in order to alleviate local tissue damage. Oral lichen planus remains uncured. keywords: berberine; cells; expression; hydrochloride; level; lichen; lichen planus; mirna-140; oral; pathway; planus; tlr4; wang cache: bjp-43513.pdf plain text: bjp-43513.txt item: #727 of 942 id: bjp-43522 author: Xu, Gang; Lv, Xin; Lu, Ke; Shen, Ming Hai; Zhang, Qing Hua; Pan, Wan Neng title: Effect of capecitabine on breast cancer patients with different estrogen receptor status date: 2020 words: 7331 flesch: 32 summary: In the 12th St. Gallen Interna- tional Breast Cancer Conference, a new approach to the classification of breast cancer patients according to intrinsic biological subtypes has been adopted by an expert panel. Abstract This meta-analysis is to compare the efficacy of capecitabine versus non- capecitabine chemotherapy on breast cancer patients with different estrogen receptor status. keywords: breast; cancer; capecitabine; et al; u p cache: bjp-43522.pdf plain text: bjp-43522.txt item: #728 of 942 id: bjp-43807 author: Sundar, Ranjitha Dhevi V.; Srikanth, Lavanya; Manognya, P Swethana; Yuvaraja, Sreenidhi; Arunachalam, Sathiavelu title: In vitro antibacterial activity of Dracaena victoria leaf extract date: 2019 words: 1412 flesch: 54 summary: In vitro antibacterial activity of Dracaena victoria leaf extract. Mahalingam R, Bharathidasan R, Ambikapathy V, Panneerselvam A. Studies on antibacterial activity of some medicinal plant against human pathogenic microorganism. keywords: activity; dracaena; ethyl; extract cache: bjp-43807.pdf plain text: bjp-43807.txt item: #729 of 942 id: bjp-44170 author: Shah, Muhammad Abdur Rehman; Khan, Rahmat Ali; Ahmed, Mushtaq title: Anti-diabetic activity of Iphiona aucheri leaf extract date: 2020 words: 7790 flesch: 49 summary: Bangladesh Journal of Pharmacology Research Article Anti-diabetic activity of Iphiona aucheri leaf extract BJP Introduction The common problems in diabetes mellitus include the occurrence of hypercholesterolemia, hypertriglyceri- demia and low serum high-density lipoprotein cholesterol (HDL-C) in diabetics as compared to normal individuals (Schofield et al., 2016, Vijayaraghavan, 2010). Anti-diabetic activities of several plants like Eclipta alba (Ananthi et al., 2003), Artemisia vulgaris (Daradka et al., 2014), Glossocardia bosvallea (Chethan et al., 2014), Wedelia chinesis (Senthilkumar et al., 2008), Wedelia trilobata (Gallé et al., 2014) keywords: activities; activity; alloxan; antioxidant; aucheri; chloroform; control; diabetes; diabetic; et al; extract; fractions; leaves; methanolic; methanolic extract; phenolic; rats; scavenging; serum; test; total cache: bjp-44170.pdf plain text: bjp-44170.txt item: #730 of 942 id: bjp-44399 author: Sundar, Ranjitha Dhevi V.; Arunachalam, Sathiavelu title: Anti-inflammatory and antifungal activity of Dracaena victoria leaf extract date: 2020 words: 1247 flesch: 53 summary: From the genus Dracaena, Draceana angustifolia Roxb. was reported to have anti-inflammatory activity. Compared to petroleum ether extract, ethyl acetate showed maximum activity. keywords: acetate; activity; ether; ethyl; petroleum cache: bjp-44399.pdf plain text: bjp-44399.txt item: #731 of 942 id: bjp-44526 author: Huyen, Vu Thi Thu; Minh, Le Thi Hong; Quyen, Vu Thi; Anh, Nguyen Mai; Cuc, Nguyen Thi Kim; Luyen, Nguyen Thi; Dat, Nguyen Tien title: Antimicrobial metabolites from Streptomyces sp. strain PDH23 derived from marine sponge Rhabdastrella globostellata date: 2020 words: 1380 flesch: 58 summary: Corresponding author: email: ngtiend@imbc.vast.vn References Aoki S, Sanagawa M, Watanabe Y, Setiawan A, Arai M, Koba- yashi M. Novel isomarabarican triterpenes, exhibiting selective antiproliferative activity against vascular endo- thelial cells, from marine sponge Rhabdastrella globostellata. Bangladesh J Pharmacol. keywords: globostellata; sponge cache: bjp-44526.pdf plain text: bjp-44526.txt item: #732 of 942 id: bjp-45249 author: Ferdous, Asiya; Misbahuddin, Mir; Sattar, Abu Naser Ibne title: Effects of tetracycline and clotrimazole ointments in the treatment of palmar arsenical keratosis date: 2020 words: 6650 flesch: 56 summary: The oral formulations studied to treat keratosis are the antioxidants (Yerebakan et al., 2002; Son et al., 2008; Khandker et al., 2006), garlic oil (Misbahuddin et al., 2013), kala jeera oil (Bashar et al., 2014), spirulina, zinc (Misbahuddin et al., 2006; Rahman et al., 2006) and selenium (Momin et al., 2007; Krohn et Abstract A double-blind, randomized, placebo-controlled trial to evaluate the effect of Nigella sativa on palmar arsenical keratosis patients. keywords: arsenic; bangladesh; clotrimazole; enterobacter; et al; growth; keratosis; media; palmar; patients; samples; skin; spp; tetracycline; treatment cache: bjp-45249.pdf plain text: bjp-45249.txt item: #733 of 942 id: bjp-45334 author: Akbar, Shehla; Ishtiaq, Saiqa title: Hepatoprotective effect of Misopates orontium in rats date: 2020 words: 4618 flesch: 60 summary: Treatment with M. orontium extracts normalized the elevated levels of serum enzymes is a clear manifesta- tion of its hepatoprotective effect. This activity helped us to check the toxic effect of plant extract on the mechanical strength of the cell membrane. keywords: acetate; activity; dna; ethyl; extract; group; hepatoprotective; lane; paracetamol; study cache: bjp-45334.pdf plain text: bjp-45334.txt item: #734 of 942 id: bjp-45800 author: Sundar, Ranjitha Dhevi V.; Arunachalam, Sathiavelu title: Antibacterial activity of Dracaena colorama date: 2020 words: 1171 flesch: 57 summary: The present study aimed to evaluate the antibacterial activity of D. colorama leaf extracts against microbial pathogens. Antibacterial activity of Dracaena colo- rama Sir, The antibacterial effect of Dracaena cinnabari (Altwair and Edrah, 2015), D. mahatma (Saranya et al., 2018), D. marginata (Shiny et al., 2012), D. spicata (Nazneen, 2013) and D. victoria (Sundar et al., 2019) have been described. keywords: activity; bangladesh; extract cache: bjp-45800.pdf plain text: bjp-45800.txt item: #735 of 942 id: bjp-46001 author: Jin, Peng; Zhao, Tao; Wei, Yueyue; Zhao, Fang title: Efficacy of beta-blockers in the treatment of sepsis date: 2021 words: 7041 flesch: 55 summary: Wei F, Dong H, Lu L, Xue H. Protective effect of esmolol on myocardium of systemic sepsis patients. Bangladesh J Pharmacol. keywords: analysis; beta; effect; file:///d:/20; group; hours; meta; patients; sepsis; studies cache: bjp-46001.pdf plain text: bjp-46001.txt item: #736 of 942 id: bjp-4610 author: Nahar, Ainun; Ashrafuzzaman, Syed; Islam, M. N.; Alam, M. Shah title: Studies on antidermatophytic effect of Allamanda cathertica date: 2010 words: 1504 flesch: 55 summary: The present study demonstrates the antidermatophytic effect of whole plant extract of A. cathartica. Literature survey revealed that different plant extracts and their isolated compounds have been found to be effective against various species of fungus which are responsible for ringworm diseases (Acharya and Chatterjee, 1975; keywords: bangladesh; cathartica; disc; extract; rajshahi cache: bjp-4610.pdf plain text: bjp-4610.txt item: #737 of 942 id: bjp-46647 author: Ayyakkannu, Purushothaman; Yahyah, Showket ; Packirisamy, Meenatchi ; Paranthaman, Subramanian Rajasekaran title: Anti-cancer effect of naringin in human lung carcinoma cell line date: 2023 words: 1854 flesch: 55 summary: As shown in Figure 2 naringin induced DNA fragmentation on lung cancer cell lines. Also pro-apoptotic and anti-apoptotic proteins’ expression pattern are analyzed in the present study on A549 lung cancer cell lines in vitro. keywords: a549; cancer; cell; dna; figure; lung; naringin cache: bjp-46647.pdf plain text: bjp-46647.txt item: #738 of 942 id: bjp-4687 author: Shoeb, Mohammad; Begum, Shahanara; Nahar, Nilufar title: Study of an endophytic fungus from Aquilaria malaccensis Lamk date: 2010 words: 2744 flesch: 60 summary: Endophytic fungi spend the whole or parts of its life cycle colonizing inter or intra- cellularly inside the healthy tissues of the host plant. Some species of endophytic fungi have been identified as sources of anticancer, antidiabetic, insecticidal, immunosuppressive and biocontrol compounds. keywords: acetate; ethyl; extract; nmr; ppm cache: bjp-4687.pdf plain text: bjp-4687.txt item: #739 of 942 id: bjp-4693 author: Devnath, Hari Pado; Islam, Md. Rabiul title: Synthesis of some pyrazolone derivatives from ciprofloxacin and study of their cytotoxicity date: 2010 words: 2101 flesch: 59 summary: Rf values (CHCHMeOH =9:1) Color of compounds 1a 88 215 0.74 White 1b 82 203 0.73 Yellow 1c 88 220 0.69 White brown Table II Cytotoxicity activity (IC50, after 4 hours) of synthesized compounds against brine shrimps Tested compounds Concentration of sample (µg/mL) % of mortality IC50 (in gg/mL) Remarks 1 0.1 63.6 0.04 Moderately active 0.1 81.8 0.2 80.0 1.0 80.0 1a 0.1 71.4 0.02 Highly active 0.1 76.7 0.2 78.9 1.0 80.0 1b 0.1 81.8 0.02 Very highly active 0.1 81.8 0.2 90.0 1.0 100.0 1c 0.1 80.0 0.02 Highly active 0.1 88.9 0.2 88.9 1.0 100.0 IC50: 0.01-0.02, very highly active; IC50: 0.02-0.03, highly active; IC50: 0.03-0.04 moderately active; IC50: 0.04-0.05, Active; IC50: >45, weakly active Author Info Md. The resulting spectral data analyses of synthesized compounds: Compound 1a: IR (vmax, KBr, cm-1): 3200.6 cm-1(s, sh, VN- H); 3070 cm-1((s, sh, VC-H, aromatic); 920 cm-1(s, sh, VC-H, aromatic, out of plane); 2961 cm-1(w, sh, VC-H CH2); 1447.5 and 1378 cm-1(s, sh, vC-H bending, CH2); 1612 and 1490 cm-1(s, sh, vc-c, aromatic); 1604 cm-1(s, sh, VC-N); 1700 cm-1(s, sh, VC=O, lactam), 1576 cm-1(s, sh, VN -H, bending); 1652 cm-1(m, VC=C, alkene); 1028 cm-1(s, sh, vc- N amine); 858 cm-1(s, br., VN-H, wagging); 752 cm -1(s, sh, VC-F ). keywords: aromatic; ciprofloxacin; cm-1(s; derivatives cache: bjp-4693.pdf plain text: bjp-4693.txt item: #740 of 942 id: bjp-4700 author: Rahman, Md. Atiar; Ahsan, Taslima; Islam, Saiful title: Antibacterial and antifungal properties of the methanol extract from the stem of Argyreia argentea date: 2010 words: 2037 flesch: 49 summary: This results indicate that A. argentea stem extract has promising antibacterial activity. In the assay of antifungal activity (Table II), A. argentea stem extract inhibited the mycelia growth of Aspergillus flavous, Fusarium equiseti (Figure 2B), Altenaria alternate (Figure 2A) and Colletotrichum corphori with the %inhibition of 44.4, 66.7, 44.4 and 75.6%, respectively, whereas no inhibition was observed against Aspergillus niger (Figure 2C) and Aspergillus fumigates. keywords: activity; argentea; bangladesh; extract; gram; inhibition cache: bjp-4700.pdf plain text: bjp-4700.txt item: #741 of 942 id: bjp-47113 author: Purushothaman, Ayyakkannu; Sundaram, Ramalingam title: Lipid lowering efficacy of fraxetin, a coumarin derivative on high fat diet induced hypercholesterolemic rats date: 2020 words: 1926 flesch: 58 summary: A large number of literatures reported that various medi- cinal plants had lipid lowering effects, for example, Pterodon emarginatus (Dal Forno et al., 2019), Salvia hispanica (Rodrigues et al., 2018), Stellaria media (Khan et al., 2019), Zingiber officinale (Bekkouch et al., 2019), Lagenaria siceraria, Commiphora wightii and Glycyrriza glabra (Srivastava and Srivastava, 2018). Phytotherapy could be a suitable alternative for the treatment of hyperlipidemia (Liu et al., 2011). keywords: fraxetin; frx; index; lipid; mg\kg; rats cache: bjp-47113.pdf plain text: bjp-47113.txt item: #742 of 942 id: bjp-4714 author: Jawale, Chetan; Kirdak, Rambhau; Dama, Laxmikant title: Larvicidal activity of Cestrum nocturnum on Aedes aegypti date: 2010 words: 1402 flesch: 49 summary: Larvicidal activity of Oestrum nocturnum on Aedes aegypti Chetan Jawale1, Rambhau Kirdak2 and Laxmikant Dama3 1Department of Zoology, HPT Arts & RYK Science College, Nashik 422005, Maharashtra; 2Directorate of Higher Education, Pune, Maharashtra; 3Department of Zoology D.B.F. Dayanand College of Arts and Science, Solapur 413004, Maharashtra, India. This extract was further fractioned and the fractions obtained (CNM1-CNM6) were tested for larvicidal activity. keywords: activity; extract; larvicidal; nocturnum cache: bjp-4714.pdf plain text: bjp-4714.txt item: #743 of 942 id: bjp-479 author: Shamsuzzoha, Mohammad title: Early days of Pharmacology education in Bangladesh date: 2006 words: 1998 flesch: 57 summary: The present building of Dhaka Medical College was then a part of Dhaka University. After completing my MBBS and pre-registration clinical assistant within the November of 1948, I joined Dhaka Medical College and Hospital in the June of 1949. keywords: college; department; dhaka; medical; pharmacology cache: bjp-479.pdf plain text: bjp-479.txt item: #744 of 942 id: bjp-480 author: Karim, Rashidul; Mannan, M. A. title: Alpha-tocopherol reduces oxidative stress in perinatal asphyxia date: 2006 words: 2809 flesch: 50 summary: α-Tocopherol reduces oxidative stress in perinatal asphyxia Rashidul Karim and M. A. Mannan Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh. There is no comparable data regarding the role of α-tocopherol in the treatment of oxidative stress in perinatal asphyxia. keywords: asphyxia; gsh; neonates; tocopherol cache: bjp-480.pdf plain text: bjp-480.txt item: #745 of 942 id: bjp-481 author: Liton, A. Kashem; Islam, M. Rabiul title: Synthesis of hydantoin and thiohydantoin related compounds from benzil and study of their cytotoxicity date: 2006 words: 3017 flesch: 73 summary: Mass: m/z (%of relative intensity) 282 (M+.100%), 205 (22%), 180(68%), 165 (50%), 121 (7%), 104 (72%), 77 (49%), 59 (6%), 51 (17%), 39 (3%). 13C-NMR (DMSO): δ 175.19 (C -4); δ 156.36 (C-2); δ 140.27 (C-6); δ 128.87 (C-7); δ 128.39 (C-8); δ 126.93 (C-9); δ 70.56 (C-5). keywords: aromatic cache: bjp-481.pdf plain text: bjp-481.txt item: #746 of 942 id: bjp-482 author: Begum, Nasim A.; Dewan, Zesmin F.; Nahar, Nilufar; Mamun, M. I. Rouf title: Effect of n-hexane extract of Nigella sativa on gentamicin-induced nephrotoxicity in rats date: 2006 words: 3072 flesch: 57 summary: A recent study suggested that N. sativa oil (Ali, 2004) given prophylactically was able to alleviate gentamicin nephrotoxicity in rats. N. sativa (kalajira) occupies a unique position among the herbal products of Southeast Asia as a natural remedy for a number of illnesses. keywords: extract; gentamicin; hexane; nephrotoxicity; rats; sativa; serum cache: bjp-482.pdf plain text: bjp-482.txt item: #747 of 942 id: bjp-483 author: Al-Amin, Mohammad; Islam, M. Rabiul title: Synthesis of some bis-triazole derivatives as probes for cytotoxicity study date: 2006 words: 2536 flesch: 62 summary: [3,4-b]-1,3,4-thiadiazol-4-yl] alkanes, 3a-e. The structures of compounds 1a-e, 2a-d and 3a-e were confirmed on the basis of IR, 1H-NMR and 13C-NMR spectral data analysis. The purity of compounds was checked by TLC on silica gel plates and iodine was used as a visualizing agent. keywords: compounds cache: bjp-483.pdf plain text: bjp-483.txt item: #748 of 942 id: bjp-484 author: E-Tabassum, Noor- title: Effect of alpha-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat date: 2006 words: 4004 flesch: 56 summary: Our body also contains α-lipoic acid, which is a short chain fatty acid with sulfhydryl (-SH) groups that has potent anti-oxidant property (Packer et al., 1995). Anti- oxidant properties of α-lipoic acid are due to its ability to scavenge hydroxy radicals, hypochlorous acid and singlet oxygen (Biewenga et al., 1997). keywords: acid; arsenic; gsh; lipoic; liver; protein; tissues cache: bjp-484.pdf plain text: bjp-484.txt item: #749 of 942 id: bjp-48496 author: Mat Jalil, Mohd Taufiq; Ibrahim, Darah title: Antimicrobial activity of volatile compounds produced by endophytic fungi associated with Ocimum sanctum date: 2020 words: 1618 flesch: 52 summary: Antimicrobial activity of volatile compounds produced by endophytic fungi associated with Ocimum sanctum Sir, Endophytic fungi are known as biosynthesizers inside their host plants (Owen and Hundley, 2004). Muscodor spp. is one of a well-known fungus that able to produce volatile antimicrobial compounds. keywords: activity; compounds; fungi; ibrl; test cache: bjp-48496.pdf plain text: bjp-48496.txt item: #750 of 942 id: bjp-485 author: Nahar, Shamsun title: Evaluation of medical teachers and traditional teaching in Pharmacology date: 2006 words: 866 flesch: 55 summary: 2006; 1: 33-34. Evaluation of medical teachers and tradi- tional teaching in pharmacology Sir, Medical teaching is a noble profession in the field of medical science. Bangladesh Journal of Pharmacology Volume: 1; Number 1; Year 2006 Cite this article as: Nahar S. Evaluation of medical teachers and traditional teaching in pharmacology. keywords: medical; pharmacology cache: bjp-485.pdf plain text: bjp-485.txt item: #751 of 942 id: bjp-486 author: Shoeb, Mohammad title: Anti-cancer agents from medicinal plants date: 2006 words: 3067 flesch: 66 summary: Anti-cancer agents from medicinal plants Mohammad Shoeb Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh. However, further investigations are necessary for their use as anti-cancer agents. keywords: agents; bangladesh; cancer; cragg; newman; ome; plants; treatment cache: bjp-486.pdf plain text: bjp-486.txt item: #752 of 942 id: bjp-487 author: Khandker, Salamat; Dey, Ranjit Kumar; Islam, A. Z. M. Maidul; Ahmad, Sheikh Akhtar; Al-Mahmud, Ifthaker title: Arsenic-safe drinking water and antioxidants for the management of arsenicosis patients date: 2006 words: 5286 flesch: 55 summary: Group V: Drinking water from both red and green- marked tube wells (irregular quality of drinking water) and/or irregular intake of antioxidants. Amongst those who had used both arsenic safe drinking water and regular medications 90.5% showed improvement of melanosis, 86.4% showed improvement of keratosis but none showed deterioration. keywords: antioxidants; arsenic; arsenicosis; bangladesh; drinking; group; patients; respondents; study; tube; water; wells cache: bjp-487.pdf plain text: bjp-487.txt item: #753 of 942 id: bjp-488 author: Nahar, Begum Lutfun; Hossain, A. K. M. Mosharrof; Islam, M. Monirul; Saha, Dipti Rani title: A comparative study on the adverse effects of two antituberculosis drugs regimen in initial two-month treatment period date: 2006 words: 4589 flesch: 63 summary: In the 5-drug treatment group before initiation of treatment regimen the estimated serum glucose level was 91.9 ± 25.5 mg/dL. After 2 and 8 weeks of inception of treatment regimen creatinine level was detected as 86.0 ± 27.2 and 84.5 ± 16.6 mg/dL respectively (Table III). In the 4-drug treatment group before initiation of treatment regimen the estimated creatinine level was 1.1 ± 0.4 mg/dL. After 2 and 8 weeks of inception of treatment regimen creatinine level was detected as 1.1 ± 0.4 and 1.0 ± 0.2 mg/dL respectively (Table II). keywords: drug; effects; group; level; patients; regimen; treatment; weeks cache: bjp-488.pdf plain text: bjp-488.txt item: #754 of 942 id: bjp-489 author: Liton, A. Kashem; Islam, M. Rabiul title: Condensation reaction of benzil with resorcinol and the establishment of the spectral data as well as cytotoxicity study date: 2006 words: 2655 flesch: 70 summary: The values at 1597 and 1581 cm-1 exhibit C=C group in aromatic ring. Bangladesh J Pharmacol 2006; 1: 58-63 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index; ISSN: keywords: aromatic; cm-1; group; portion; presence cache: bjp-489.pdf plain text: bjp-489.txt item: #755 of 942 id: bjp-490 author: Moosa, Abu Saleh M.; Rashid, Mamun Ur; Asadi, A. Z. S.; Ara, Nazma; Uddin, M. Mojib; Ferdaus, A. title: Hypolipidemic effects of fenugreek seed powder date: 2006 words: 2016 flesch: 57 summary: The present study suggests that fenugreek seed powder would be considered as effective agent for lipid lowering purposes. They were advised to swallow 25 gm of fenugreek seed powder twice daily (after breakfast and after dinner). keywords: cholesterol; day; fenugreek; lipid; serum cache: bjp-490.pdf plain text: bjp-490.txt item: #756 of 942 id: bjp-4901 author: Singh, Aditi; Sarin, Renu title: Artemisia scoparia: A new source of artemisinin date: 2010 words: 2013 flesch: 60 summary: Bangladesh Journal of Pharmacology Research Article Artemisia scoparia: A new source of artemisinin BJP Introduction Malaria is one of the world’s most important parasitic diseases. Artemisia scoparia: A new source of artemisinin Aditi Singh and Renu Sarin Laboratory of Bioactive Compounds, Department of Botany, University of Rajasthan, Jaipur 302004, India. keywords: annua; artemisia; artemisinin; plant; scoparia cache: bjp-4901.pdf plain text: bjp-4901.txt item: #757 of 942 id: bjp-4909 author: Rahman, Md. Faizur; Misbahuddin, Mir title: Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat date: 2010 words: 3258 flesch: 58 summary: Effect of folic acid and tetrahydro- folate on tissue arsenic level in rat. Effect of folic acid and tetrahydrofolate on tissue arsenic level in rat Md. keywords: acid; arsenic; bangladesh; folic; group; rats; skin; tetrahydrofolate cache: bjp-4909.pdf plain text: bjp-4909.txt item: #758 of 942 id: bjp-491 author: Saha, Beauty title: Effect of ascorbic acid on reduced glutathione level in arsenic-loaded isolated liver tissues of rat date: 2006 words: 2185 flesch: 53 summary: Next the time course of the effect of ascorbic acid on GSH level in arsenic loaded liver tissues of rat was studied (Figure 1). I Effect of different concentrations of ascorbic acid on GSH level in arsenic loaded liver tissues First incubation (40 min) Second incubation (40 min) Amount of GSH (mg/g protein) %Increased None 11.5 ± 0.3 - Arsenic (100 mg/mL) Ascorbic acid (20 mg/mL) 14.2 ± 0.1 22.6 Ascorbic acid (200 mg/mL) 20.9 ± 0.1 80.5 Ascorbic acid (2 mg/mL) 26.8 ± 0.2 131.8 Figure 1: Time course of the effect of ascorbic acid on GSH level in arsenic loaded liver tissues 70 Bangladesh J Pharmacol 2006; 1: 68-71 Rabbani GH, Saha SK, Marni F, Akhtar M, Alauddin M, Mitra AK, Nasir M, Chowdhury AKA. keywords: acid; arsenic; ascorbic; gsh; tissues cache: bjp-491.pdf plain text: bjp-491.txt item: #759 of 942 id: bjp-492 author: Haqq, Mohammed Ataul; Rahman, Md. Hamidur; Khanam, Selina; Mannan, M. A. title: Efficacy of nebulized magnesium sulfate in the treatment of acute exacerbation of asthma in children date: 2006 words: 5498 flesch: 66 summary: According to the grouping based on label number, each set of eppendorf tube was filled with appropriate solution i.e.; isotonic magnesium sulfate solution in magnesium sulfate group and normal saline in control group. In magnesium sulfate group and control group height was 57.2 ± 5.4 inches and 54.9 ± 6.2 inches respectively. keywords: group; magnesium; min; pefr; response; salbutamol; sulfate cache: bjp-492.pdf plain text: bjp-492.txt item: #760 of 942 id: bjp-493 author: Rahman, Md. Shamsur; Begum, Zinnat Ara; Samad, Md. Khoshroz title: Prescribing pattern of non-steroidal anti-inflammatory drugs at outpatient departments of teaching hospitals date: 2007 words: 3348 flesch: 51 summary: Average cost of prescribed drugs per prescription in the medical outpatient departments were Tk. 149.4, 166.7, 339.6 and the surgical outpatient departments were 157.2, 177.7, 230.6 respectively of DMCH, BSMMUH and PH (Table V). Bennett PN, Brown MJ. Inflammation, arthritis and nonsteroidal anti-inflammatory drugs. keywords: departments; dmch; drugs; medical; nsaids; outpatient cache: bjp-493.pdf plain text: bjp-493.txt item: #761 of 942 id: bjp-494 author: Islam, Md. Rabiul; Mohsin, Mohammad title: Synthesis of isatin, 5-chloroisatin and their Δ2-1,3,4 oxadiazoline derivatives for comparative cytotoxicity study on brine shrimp date: 2007 words: 3653 flesch: 67 summary: d ppm : 11.84 (br.s, 1H, N1-H, lactam); 11.28 (s, 1H, N2-H); 10.84 (br.s, 1H, N3-H); 7.56 (d, J=7.8 Hz., 1H, C1-H), 7.37 (t, 1H, C2-H), 7.09-7.16 (m, 1H; C3-H); 7.00 (d, J=7.8 Hz., 1H, C4-H). Four aromatic protons of C1-H, C2-H, C3-H, and C4-H appear at d 6.90 (d, J=7.8 Hz., 1H, C4-H), d 7.12 (t, N, C2-H), d 7.56 (t, C3- H) and d 7.49 (d, J=7.8 Hz., 1H, C4-H) respectively. keywords: 35cl cache: bjp-494.pdf plain text: bjp-494.txt item: #762 of 942 id: bjp-495 author: Gupta, Kaberi Das; Hossain, A. K. M. Mosharrof; Jaigirdar, Abdur Raquib; Uddin, Borhan; Choudhury, Tridiv; Saha, Dipti Rani title: Effects of ondansetron alone and in combination with domperidone in the prevention of chemotherapy-induced nausea and vomiting in breast cancer patients date: 2007 words: 3759 flesch: 52 summary: Abstract The efficacy and safety of ondansetron, administered alone and in combination with domperidone to prevent chemotherapy-induced nausea and vomiting of breast cancer patients receiving chemotherapy FAC regimen (5-fluorouracil, adriamycin and cyclophosphamide) were evaluated. Effects of ondansetron alone and in combination with domperidone in the prevention of chemotherapy-induced nausea and vomiting in breast cancer patients Kaberi Das Gupta1, A. K. M. Mosharrof Hossain1, Abdur Raquib Jaigirdar2, Borhan Uddin1, Tridiv Choudhury2 and Dipti Rani Saha1 1Department of Pharmacology, Sylhet M. A. G. Osmani Medical College, Sylhet 3100; 2Department of Radiotherapy, Sylhet M. A. G. Osmani Medical College, Sylhet 3100, Bangladesh. keywords: appetite; cancer; chemotherapy; domperidone; nausea; ondansetron; patients; vomiting cache: bjp-495.pdf plain text: bjp-495.txt item: #763 of 942 id: bjp-496 author: Alam, Md. Ashraful; Awal, Md. Abdul; Mostofa, Mahbub; Islam, Md. Kamrul; Subhan, Nusrat title: In vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered date: 2007 words: 3494 flesch: 52 summary: The current study has been carried out for the initial understanding of the in vitro displacement interaction of the two drug atenolol and amlodipine on binding site of bovine serum albumin. Site-specific probes method We may use different site-specific probes to enhance our understanding of the drug-BSA interaction and thereby characterization of binding sites of the drugs used in the study on the BSA molecule. keywords: amlodipine; atenolol; binding; bsa; probe; protein; site; warfarin cache: bjp-496.pdf plain text: bjp-496.txt item: #764 of 942 id: bjp-497 author: Umar, Badar Uddin title: Effect of hexane extract of spinach in the removal of arsenic from rat date: 2007 words: 4921 flesch: 59 summary: Estimation of tissue arsenic level The amount of total arsenic in tissues was measured by quantitative colorimetric method for total arsenic estimation using SDDC method. Selenium intervention in reducing arsenic levels in different tissues. keywords: acid; arsenic; extract; hexane; level; rats; spinach; water cache: bjp-497.pdf plain text: bjp-497.txt item: #765 of 942 id: bjp-498 author: Uddin, Md. Burhan; Hossain, A. K. M. Mosharrof; Alam, Meer Mahbubul; Hossain, A. Z. M. Shakhawat title: Ketorolac and pethidine in post-operative pain relief date: 2007 words: 5004 flesch: 57 summary: of post-operative pain However, the availability of data related to efficacy and safety of ketorolac in post-operative pain in our population is not adequate. keywords: analgesic; difference; group; hours; ketorolac; pain; pethidine; score; vrs cache: bjp-498.pdf plain text: bjp-498.txt item: #766 of 942 id: bjp-499 author: Iqbal, Md. Jalaluddin; Dewan, Fauzia Z.; Chowdhury, S. A. R.; Mamun, M. I. R.; Moshiuzzaman, M.; Begum, Monowara title: Pre-treatment by n-hexane extract of Phyllanthus niruri can alleviate paracetamol-induced damage of the rat liver date: 2007 words: 3226 flesch: 62 summary: Bangladesh Journal of Pharmacology Research Article PrePrePre---treatment by treatment by treatment by nnn---hexane extract hexane extract hexane extract of of of Phyllanthus niruri Phyllanthus niruri Phyllanthus niruri can alleviate can alleviate can alleviate paracetamolparacetamolparacetamol---induced damage of the induced damage of the induced damage of the rat liverrat liverrat liver BJP Introduction Phyllanthus niruri (Bhui amla) is a well-known herb of Bangladesh and the sub-continent. In the H+P group, the mean serum ALT, serum AST and serum bilirubin concentrations were at significantly (p<0.001) lower levels compared to those in group P. keywords: extract; group; liver; niruri; paracetamol; serum cache: bjp-499.pdf plain text: bjp-499.txt item: #767 of 942 id: bjp-500 author: Hossain, Shakhawat; Molla, Motiur Rahman; Akhter, Mahmuda title: Serum iron concentration and total iron binding capacity in patients of oral squamous cell carcinoma date: 2007 words: 3430 flesch: 65 summary: Level of serum iron, ferritin, total iron binding capacity (TIBC) and transferrin saturation are the important diagnostic measures of iron deficiency (Hepplestone and Pippard, 1996; Dallman et al., 1980; Dallman and Reeves, 1984). So, TIBC has a relation with OSCC like serum iron. keywords: bangladesh; cancer; iron; level; patients; serum; study; tibc cache: bjp-500.pdf plain text: bjp-500.txt item: #768 of 942 id: bjp-5003 author: Sarker, Sujit Kumar; Begum, Nilufar; Mondal, Dinesh; Siddique, Md. Abdullah; Rashid, Mohammad A. title: In vitro study of antiamoebic effect of methanol extract of mature seeds of Carica papaya on trophozoites of Entamoeba histolytica date: 2010 words: 1659 flesch: 60 summary: h is to ly tic a (% ) 200 100 0 -100 -200 0 1 2 3 6 13 25 50 100 200 B Figure 1: Mean growth of E. histolytica in presence of extract of C. papaya (A) and metronidazole (B) value of metronidazole was <2.5 µg/mL (Tona et al., 1998) and the IC50 value of C. papaya seeds was 153 µg/ mL, while that of metronidazole was 0.04 µg/mL (Calzada et al., 2006). The result of the present study is consistent with the findings observed by previous study but difference in MIC value which may be due to difference in variety of papaya seeds, full maturity of seeds, time of seed collection, extraction procedure, Strain of E. histolytica, culture media or incubation period. keywords: extract; histolytica; papaya; study cache: bjp-5003.pdf plain text: bjp-5003.txt item: #769 of 942 id: bjp-50244 author: Song, Hongmei; Ye, Xuxiao; Liang, Tao; Yan, Dongliang; Li, Zuowei title: Expression of HOXC10 gene regulates the growth and invasion of prostate cancer cells date: 2021 words: 4420 flesch: 57 summary: The transwell assay showed that HOXC10 significantly (p<0.05) inhibits the invasion of prostate cancer cells. Expression of HOXC10 gene regulates the growth and invasion of prostate cancer cells Hongmei Song1, Xuxiao Ye2, Tao Liang2, Dongliang Yan2 and Zuowei Li2 Department of 1Interventional Radiology and 2Urology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Science, Shanghai 201306, China. keywords: cancer; cells; du145; erk; gene; hoxc10; lines; mek; prostate; prostate cancer cache: bjp-50244.pdf plain text: bjp-50244.txt item: #770 of 942 id: bjp-50548 author: Zhou, Yi; Wang, Liguo; Lin, Hui; Wang, Yunxia; Hou, Kezhu title: Bufalin inhibits the growth and epithelial to mesenchymal transition of human gastric cancer cells via modulation of MEK/ERK pathway date: 2021 words: 4232 flesch: 52 summary: Gastric cancer cells (MGC-803) were incubated for 24 hours at 37ºC without or with (2.5, 5, 10, 20, 40, 80 or 160 µM) bufalin in a 96-well plate and then the viability of cancer cells was estimated by CCK-8 proliferation assay. Bufalin was also shown to modulate mTOR and ERK-driven signaling cascades in gastric cancer cells (Qi et al., 2019). keywords: bufalin; cancer; cancer cells; cells; cycle; erk; hours; invasion; mek; mgc-803 cache: bjp-50548.pdf plain text: bjp-50548.txt item: #771 of 942 id: bjp-50575 author: Zyuz`kov, Gleb N.; Miroshnichenko, Larisa A.; Polyakova, Tatyana Yu; Stavrova, Larisa A.; Simanina, Elena V. title: Wound healing properties of the protein kinase A inhibitor and the mechanisms of their development date: 2021 words: 5188 flesch: 52 summary: Secretion of growth factors by stromal wound cells The experiments did not detect changes in the secretion of growth factors by stromal cells obtained from the surface of the wound. They are based on the activation of mesenchymal progenitor cells. keywords: activity; cells; control; day; et al; growth; healing; inhibitor; kinase; mesenchymal; progenitors; protein; skin; wound cache: bjp-50575.pdf plain text: bjp-50575.txt item: #772 of 942 id: bjp-5158 author: Habib, Md. Anwar; Anisuzzaman, Abu Syed Md; Khan, Md. Rofiqul Islam; Gafur, Md. Abdul title: Chemical and pharmacological characterization of hypolipidemic compound from Cajanus Cajan date: 2010 words: 3352 flesch: 56 summary: When the condition of diabetes was established animals with blood glucose levels above 11.1 mM were selected for the study. Redgram was found to reduce blood glucose and lipid profile in human volun- teers (Panlasigui et al., 1995). keywords: bangladesh; blood; compound; diabetic; glucose; methanol; mice; pharmacol; redgram cache: bjp-5158.pdf plain text: bjp-5158.txt item: #773 of 942 id: bjp-51605 author: Xu, Qian; Wang, Li Na; Zhao, Jing Yi; Xiao, Yan Hong; Du, Chao title: Effects of paeonol on proliferation and collagen synthesis of rat cardiac fibroblasts induced by aldosterone date: 2021 words: 5180 flesch: 54 summary: Protein concentration was measured using the BCA method, SDS-PAGE electrophoresis, membrane trans- fer, and the addition of primary antibodies: (1:200 for type III collagen and 1:3000 for β-actin), and incubation for two hours at room temperature on a shaker. After washing with TBST, the secondary antibody was add- ed: (the dilution ratio of type III collagen was 1:3000, the dilution ratio of β-actin was 1:5000) and incubated in a shaker at room temperature for one hour. keywords: aldosterone; cardiac; cell; collagen; dose; expression; fibroblasts; group; model; paeonol; remodeling; tgf; type cache: bjp-51605.pdf plain text: bjp-51605.txt item: #774 of 942 id: bjp-5188 author: Sathi, Zakia Sultana; Habib, Md. Anwar; Anisuzzaman, Abu Syed Md.; Islam, Md. Anwarul title: Two isomeric compounds from Streptomyces species and their antimicrobial activity date: 2010 words: 2875 flesch: 55 summary: Antimicrobial screening Antimicrobial compound I and II (25 and 50 qg per disc, respectively) were determined against four Gram posi- tive and five Gram negative bacteria, and four patho- genic fungus by standard disc diffusion method (Masako et al., 2004; Bauer et al., 1996). The compounds seem to be first report of isomeric compound from Streptomyces species having antimicrobial activity. keywords: activity; carbon; compound; group; methyl; proton; signals cache: bjp-5188.pdf plain text: bjp-5188.txt item: #775 of 942 id: bjp-52090 author: Shen, Shuang; Hou, Yunlong; Wu, Yiling title: Tongxinluo preserves the renal function in diabetic kidney disease via protecting the HK-2 cells from the patterns of programmed cell death date: 2021 words: 6617 flesch: 51 summary: The apoptosis of renal tubular epithelial cells in the hypoxic milieu in diabetic kidney disease is a signifi- cant factor that causes renal functional and pathological changes (Leonard et al., 2003; Kim et al., 2011). Wang Y, Bi R, Quan F, Cao Q, Zhang D. Ferroptosis involves in renal tubular cell death in diabetic nephropathy. keywords: apoptosis; bangladesh; cell; disease; figure; glucose; group; hghp; hk-2; kidney; mice; mmol; pyroptosis; renal; tongxinluo; treatment cache: bjp-52090.pdf plain text: bjp-52090.txt item: #776 of 942 id: bjp-52655 author: Segaran, Gayathri; Sathiavelu, Mythili title: Antibacterial activity of an ornamental plant Hippeastrum fosteri date: 2021 words: 1239 flesch: 52 summary: Antibacterial activity of an ornamental plant Hippeastrum fosteri Sir, The genera Hippeastrum Herb. is native to South American and belongs to the family Amaryllidaceae with about 60 species. The ethyl acetate extract of H. fosteri leaves showed antibacterial activity (Figure 1). keywords: activity; extracts; fosteri; hippeastrum cache: bjp-52655.pdf plain text: bjp-52655.txt item: #777 of 942 id: bjp-5267 author: Ravichandran, Samuthirapandian; Jeyalakshmi, Singaram; Sudha, Sathasivam; Anbuchezhian, Ramasamy title: Antimicrobial peptides from the hemolymph of the prawn Macrobrachium rosenbergii date: 2010 words: 3602 flesch: 52 summary: Determination of antimicrobial activity The susceptibilities to antimicrobials were determined according to the technique of Bauer et al. (1966). Plasma, the haemocyte separated hemolymph was also analysed for antimicrobial activity. keywords: + +; activity; antimicrobial; female; hemocytes; hemolymph; peptides; plasma; shrimp cache: bjp-5267.pdf plain text: bjp-5267.txt item: #778 of 942 id: bjp-52948 author: Garg, Anchal; Gupta, Vardan; Tomar, Ritu; Arora, Mandeep Kumar title: Experimental models for vascular endothelial dysfunction date: 2021 words: 13414 flesch: 43 summary: Atherosclerosis, hypertension, hyperglycemia, and smoking are considered to be the self-governing risk factors and foremost determinants in the progression of vascular endothelial dysfunction (Hadi et al., 2005). Therefore, this paper aims to review various experimental animal models developed to produce vascular endothelial dysfunction. keywords: acetylcholine; adhesion; administration; aortic; blood; cells; day; disorders; dose; dysfunction; endothelial; enos; et al; expression; factors; high; hypertension; levels; male; mice; models; pharmacol; rats; rns; role; ros; serum; streptozotocin; stress; table; vascular; weeks; wistar; zhang cache: bjp-52948.pdf plain text: bjp-52948.txt item: #779 of 942 id: bjp-53018 author: Shankar, Saranya; Sathiavelu, Mythili title: Antibacterial activity of Dracaena lisa date: 2021 words: 1443 flesch: 52 summary: Shankar S, Settu S, Segaran S, Sundar RDV, Ravi L, Bangladesh J Pharmacol 2021; 16: 84-86 85 Table I Antibacterial properties of Dracaena lisa leaf extracts using agar well diffusion method Extract Concentration (µg/mL) Zone of inhibition (mm) S. aureus P. fluorescence B. subtilis K. pneumonia E. fecalis E. coli Methanol 25 - - 11 - - 50 - 5 14 - - - 100 7 8 16 9 - 7 Ethyl acetate 25 16 - 7 - - 8 50 17 - 13 12 11 15 100 19 - 28 17 14 25 Dichloromethane 25 - - 12 11 10 - 50 - - 20 13 11 10 100 - 10 24 15 14 12 Standard (ciprofloxacin in mg) 10 32 28 43 33 35 32 Phytochemical constituents of Dracaena mahatma leaves and their anti-bacterial, anti-oxidant, and anti-inflammatory significance. Antibacterial activity of Dracaena lisa Sir, Dracaena is a genus of about 120 species that belongs to the family Asparagaceae and subfamily Nolinoideae. keywords: activity; extract; leaf cache: bjp-53018.pdf plain text: bjp-53018.txt item: #780 of 942 id: bjp-5305 author: Sadeque, Md. Zafor; Begum, Zinnat Ara title: Protective effect of dried fruits of Carica papaya on hepatotoxicity in rat date: 2010 words: 2169 flesch: 58 summary: Histological examination of the liver sections pretreated with extracts of C. papaya showed remarkable reduction Bangladesh J Pharmacol 2010; 5: 48-50 49 Table I Effects of pretreatment with Carica papaya on mean serum bilirubin, ALT, AST and ALP levels in CCI4 treated rats Groups Serum bilirubin (mg/dL) Serum ALT (u/L) Serum AST (u/L) Serum ALP (u/L) C. papaya is commonly cultivated and planted in Bangladesh for its edible fruits, also grows naturally in Waste Lands. keywords: extract; group; papaya; rats; serum cache: bjp-5305.pdf plain text: bjp-5305.txt item: #781 of 942 id: bjp-53420 author: Rattanasuk, Surachai; Boongapim, Rujirek; Phiwthong, Tannatorn title: Antibacterial activity of Cathormion umbellatum date: 2021 words: 3213 flesch: 46 summary: Evaluation of antibacterial activity of honey against multidrug resistant bacteria in Ayder Referral and Teaching Hospital, Northern Ethiopia. The antibacterial activity of C. umbellatum extract was primary determined using disc diffusion assay (Boon- gapim et al., 2021; Malaka et al., 2018). keywords: activity; bacteria; extracts; methanol; umbellatum cache: bjp-53420.pdf plain text: bjp-53420.txt item: #782 of 942 id: bjp-53611 author: Lim, Hye-Sun; Jang, Yumi; Moon, Byeong Cheol; Park, Gunhyuk title: NF-κB signaling contributes to the inhibitory effects of Bombyx batryticatus on neuroinflammation caused by MPTP toxicity date: 2021 words: 4558 flesch: 52 summary: Consequently, it was found that B. batryticatus inhibited glial and microglial activation and the levels of neuroinflammatory mediators, such as Cox-2, iNOS, and NF-kB, in the substantia nigra pars compacta. It can be considered that B. batryticatus holds implications in providing anti-inflammatory neuroprotection by regulating NF-κB signaling. keywords: activation; batryticatus; control; effects; levels; mptp; neuroinflammation cache: bjp-53611.pdf plain text: bjp-53611.txt item: #783 of 942 id: bjp-54174 author: Jabeen, Qaiser; Khan, Muhammad Sohaib; Qureshi, Abdul Wahid; Rasheed, Hafiz Muhammad Farhan title: Effect of Abutilon indicum in thyroxine-induced hyperthyroidism in rat date: 2021 words: 6997 flesch: 52 summary: The majority of iso- lated compounds, identified in A. indicum extract, were alkaloids, fatty acids, flavonoids, sterols and phenols. Tripathi P, Chauhan N, Patel J. Anti-inflammatory activity of Abutilon indicum extract. keywords: abutilon; acid; activity; antioxidant; crude; day; et al; extract; hyperthyroidism; indicum; levels; p.o; thyroid; thyroxine cache: bjp-54174.pdf plain text: bjp-54174.txt item: #784 of 942 id: bjp-54481 author: Mahboob, Sabiha; Rahman, Md. Sayedur title: Reintroduction of nitrofurantoin in the treatment of uncomplicated urinary tract infection date: 2021 words: 2546 flesch: 39 summary: It is estimated that antimicrobial resistance could cause 10 million deaths per year by 2050 (Kraker et a;., 2016). Multidisciplinary approach had become the mainstay for containment of antimicrobial resistance, recycling of older antimicro- bials is one of the approaches (Cassir et al., 2014). keywords: antimicrobial; bangladesh; intervention; nitrofurantoin; rate; resistance; sensitivity cache: bjp-54481.pdf plain text: bjp-54481.txt item: #785 of 942 id: bjp-54872 author: Filiz, Ahmet Kemal; Joha, Ziad; Yulak, Fatih title: Mechanism of anti-cancer effect of β-glucan on SH-SY5Y cell line date: 2021 words: 5338 flesch: 59 summary: β-Glucan also down- regulated PARP1 and the anti-apoptotic protein Bcl-2 expressions in cancer cells, while up-regulating the tumor suppressor p53 and pro-apoptotic proteins Bax and caspase 3/9 (Xu et al., 2016). At 200 μg/mL dose, the viability of cancer cells was reduced by about 50% (Kim et al., 2009). keywords: apoptosis; bax; cancer; caspase; cells; control; glucan; oxidant; parp; status; sy5y; sy5y cells cache: bjp-54872.pdf plain text: bjp-54872.txt item: #786 of 942 id: bjp-54940 author: Segaran, Gayathri; Sathiavelu, Mythili title: Antibacterial activity of Alternanthera versicolor date: 2021 words: 1266 flesch: 46 summary: Bangladesh J Pharmacol 2021; 16: 114-116 115 Table I Antibacterial properties of A. versicolor leaf extracts using agar well diffusion method Extract Concentration (µg/mL) Zone of inhibition (mm) Bacillus subtilis Listeria monocytogenes Staphylococcus aureus Escherichia coli Klebsiella pneumoniae Methanol 25 11 10 25 - - 50 13 18 28 - 100 17 21 32 16 Ethyl acetate 25 14 14 14 - - 50 16 14 15 14 11 100 17 16 18 16 12 Dichloromethane 25 - 12 10 - - 50 18 12 11 100 25 15 15 Standard (ciprofloxacin in mg) 10 36 30 40 40 27 Figure 1: Antibacterial activity of ethyl acetate extract of A. versicolor leaves. Using sterile cork borer, wells were made on the agar plate and loaded with 100 µL of plant extracts of different concentrations (25, 50, 100 µg/mL). keywords: activity; alternanthera; extracts cache: bjp-54940.pdf plain text: bjp-54940.txt item: #787 of 942 id: bjp-55198 author: Guo, Hai-Yuan-Bo ; Liu, Xiao-Xiao; Zhu, Xiao-Yong; Yu, Zhe title: Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells date: 2021 words: 4788 flesch: 57 summary: The proliferations of lung adenocarcinoma and lung squa- mous cell carcinoma cells were significantly linearly suppressed by mulberrofuran G. By increasing mul- berrofuran G, the growth of lung adenocarcinoma and lung squamous cell carcinoma cells were increasingly down-regulated. Liang L, Hui K, Hu C, Wen Y, Yang S, Zhu P, Wang L, Xia Y, Qiao Y, Sun W, Fei J, Chen T, Zhao F, Yang B, Jiang X. Autophagy inhibition potentiates the anti-angiogenic pro- perty of multikinase inhibitor anlotinib through JAK2/ STAT3/VEGFA signaling in non-small cell lung cancer cells. keywords: a549 cells; cancer; cancer cells; cells; h226; h226 cells; invasion; jak2; lung; lung cancer; migration; mulberrofuran; nci; signaling; stat3 cache: bjp-55198.pdf plain text: bjp-55198.txt item: #788 of 942 id: bjp-55620 author: Setu, Mohosina Sultana ; Rahman, Md. Sayedur title: Application of selected components of “SPICES” model as teaching-learning method in pharmacology date: 2021 words: 3300 flesch: 55 summary: Teaching medical students the skills required critically evaluate the drug information sources for rational prescribing: Report of an exercise on evaluation of prescribing information. The present study revealed that student-centered, problem based, and integrated learning approaches are more effective than traditional method. keywords: approach; assessment; bangladesh; control; learning; medical; problem; students cache: bjp-55620.pdf plain text: bjp-55620.txt item: #789 of 942 id: bjp-5644 author: Balamurugan, G.; Muralidharan, P. title: Effect of Indigofera tinctoria on β-amyloid (25-35) mediated Alzheimer's disease in mice: Relationship to antioxidant activity date: 2010 words: 3810 flesch: 54 summary: Accepted: 30 July 2010 Available Online: 29 August 2010 DOI: 10.3329/bjp.v5i1.5644 Cite this article: Balamurugan G, Muralidharan P. Effect of Indigofera tinctoria on β- amyloid (25-35) mediated Alzhei- mer’s disease in mice: Relationship to anti-oxidant activity. KD-501, a standardized extract of Scrophularia buergeriana has both cognitive enhancing and anti-oxidant activities in mice given scopolamine. keywords: activity; alzheimer; amyloid; brain; disease; extract; glutathione; group; indigofera; methanol; tinctoria; treatment cache: bjp-5644.pdf plain text: bjp-5644.txt item: #790 of 942 id: bjp-56682 author: Dat, Ton That Huu; Oanh, Phung Thi Thuy title: Pharmacological activities and volatile organic compounds from the endophytic bacteria from the leaves of Rhizophora apiculata date: 2021 words: 1969 flesch: 40 summary: Antimicrobial activity of the extracts was determined by the microdilution (Dat et al., 2021), antioxidant and α-amylase and α-glucosidase inhibitory activities were determined using the protocol described elsewhere (Dat and Oanh, 2021), and xanthine oxidase inhibitory activity was determined using the protocol described elsewhere (Nguyen et al., 2004). For example, 4 extracts exhibited antimicrobial activity against 3 reference microorganisms and two extracts against 2 reference microorganisms. keywords: activity; desktop; extracts; file:///c:/users cache: bjp-56682.pdf plain text: bjp-56682.txt item: #791 of 942 id: bjp-5681 author: Hegde, Karunakar; Joshi, Arun B. title: Hepatoprotective and anti-oxidant effect of Carissa spinarum root extract against CCl4 and paracetamol-induced hepatic damage in rats date: 2010 words: 3033 flesch: 60 summary: SALP (U/L) Uric acid (mg/dL) Total protein (mg/dL) Total bilirubin (mg/dL) I (Vehicle control) 5 mL A 69.1 ± 2.3 58.1 ± 1.9 71.4 ± 1.6 2.8 ± 0.9 7.0 ± 0.4 1.1 ± 0.1 B 76.2 ± 3.1 64.0 ± 1.9 69.5 ± 1.1 2.9 ± 0.5 6.8 ± 0.3 1.0 ± 0.2 II (CCh/ PCM con- trol) 0.7 mL A 181.5 ± 2.7a 139.3 ± 3.1a 121.9 ± 3.0a 1.3 ± 0.2a 5.1 ± 0.2a 2.3 ± 0.3a B 186.3 ± 3.9a 141.2 ± 3.2a 129.0 ± 2.6a 1.3 ± 0.3a 5.1 ± 0.2a 2.2 ± 0.2a III (CCh/ PCM + Si- lymarin) 25 mg A 74.5 ± 1.9c 67.3 ± 2.0c 79.2 ± 1.0c 2.5 ± 0.8c 6.9 ± 0.4c 1.2 ± 0.2c A 144.9 ± 3.2c 128.1 ± 1.7b 100.9 ± 2.1c 1.9 ± 0.8§ 5.2 ± 0.3§ 2.1 ± 0.4§ B 151.6 ± 3.2c 118.3 ± 2.2c 110.5 ± 2.2c 2.0 ± 0.5b 5.7 ± 0.2b 2.1 ± 0.2§ V (CCl4/ PCM + ex- tract) 200 mg A 106.9 ± 4.0c 90.1 ± 1.3c 94.3 ± 2.6c 2.2 ± 0.5c 6.0 ± 0.2c 1.7 ± 0.16c B 121.6 ± 4.2c 99.3 ± 2.0c 101.1 ± 2.1c 2.2 ± 0.6c 6.1 ± 0.2c 1.7 ± 0.2c VI (CCb/ PCM + extract) keywords: activity; ccl4; extract; hepatoprotective; pcm; weight cache: bjp-5681.pdf plain text: bjp-5681.txt item: #792 of 942 id: bjp-570 author: Begum, Sudhira; Akhter, Nargis title: Cardioprotective effect of amlodipine in oxidative stress induced by experimental myocardial infarction in rats date: 2007 words: 3819 flesch: 55 summary: Forty-eight hours after the 2nd injection of adrenaline, serum LDH level in the vehicle and adrenaline treated rats were 696.0 + 6.4 U/L and 1425.6 + 5.4 U/L respectively. Amlodipine pretreatment caused 68.4% prevention of rise of MDA concentration of myocardial tissue was found in adrenaline treated rats. keywords: adrenaline; amlodipine; ast; group; hours; level; rats; serum cache: bjp-570.pdf plain text: bjp-570.txt item: #793 of 942 id: bjp-571 author: Rahman, Md. Atiar; Mannan, M. A.; Rahman, Md. Hamidur title: Serum iron and total iron binding capacity in severely malnourished children date: 2007 words: 2773 flesch: 63 summary: Mean serum total protein and albumin level in normal children were 76.3 ± 0.5, 43.5 ± 0.4 g/L respectively which was significantly higher (p<0.05) than that of malnourished children (64.4 ± 0.6, 30.2 ± 0.5 g/L). But mean serum globulin level was (34.2 ± 0.3 g/L) higher in malnourished children than that of normal children (32.8 ± 0.5 g/L). keywords: age; bangladesh; children; iron; serum; study cache: bjp-571.pdf plain text: bjp-571.txt item: #794 of 942 id: bjp-572 author: Hossain, Mohammad Mamun; Islam, Nazrul; Khan, Rahat; Islam, Md. Rabiul title: Cytotoxicity study of dimethylisatin and its heterocyclic derivatives date: 2007 words: 2793 flesch: 64 summary: The characterization of synthesized compounds was carried out by IR, 1H-NMR and mass spectroscopic methods (Table I). LD50 value (ppm) Remarks 1 99 Less active 6 22 Highly active 2 96 Less active 7 36 Moderately active 3 52 Weakly active 7' 31 Moderately active 4 24 Highly active 8 29 Moderately active 5 24 Highly active 8' 24 Highly active Table II Physical constants and %yield of synthesized compounds (2-8) Compound No. keywords: ch3 cache: bjp-572.pdf plain text: bjp-572.txt item: #795 of 942 id: bjp-573 author: Jahan, Tuhin; Begum, Zinnat Ara; Sultana, Sayeeda title: Effect of neem oil on some pathogenic bacteria date: 2007 words: 1006 flesch: 57 summary: Efficacy of NIM-76, a spermicidal fraction from neem oil was investigated for its antimicrobial action against certain bacteria, fungi and poliovirus as compared to whole neem oil. Cite this article as: Jahan T, Begum ZA, Sultana S. Effect of neem oil on some pathogenic bacteria. keywords: disc; neem; oil cache: bjp-573.pdf plain text: bjp-573.txt item: #796 of 942 id: bjp-574 author: Quayum, Shaheen Lipika title: Effect of water hyacinth root extract on arsenic level in different organs of arsenic-treated rat date: 2007 words: 5188 flesch: 57 summary: Estimation of tissue arsenic level (SDDC method; Bauer, 1982) Inorganic arsenic was reduced to arsine (AsH3) by zinc in strong acid solution in an arsine generator. It was sought to establish a relationship between tissue arsenic level and lipid peroxidation. keywords: a.e; acid; arsenic; bangladesh; extract; hyacinth; root; tissue; treatment; water cache: bjp-574.pdf plain text: bjp-574.txt item: #797 of 942 id: bjp-57472 author: Lim, Hye-Sun; Moon, Byeong Cheol ; Park, Gunhyuk title: Nrf2 signaling contributes to the neuroprotective effect of Cicadidae Periostracum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity date: 2022 words: 5252 flesch: 52 summary: Differentiated PC12 cells were then pretreated with Cicadidae Periostracum (0.1–50 μg/ mL) for 1 hour, followed by MPP+ (100 μg/mL) for 23 hours. Results Effects on MPP+-induced neurotoxicity in differentia- ted PC12 cells Treatment with Cicadidae Periostracum at a concentra- tion of 100 μg/mL, but not at 1–50 μg/mL, decreased the viability of PC12 and differentiated PC12 cells 24 hours after treatment (data not shown). keywords: cells; cicadidae; control; mptp; nrf2; periostracum cache: bjp-57472.pdf plain text: bjp-57472.txt item: #798 of 942 id: bjp-575 author: Ahasan, Nusrat Binta; Islam, Md. Rabiul title: Cytotoxicity study of pyrazole derivatives date: 2007 words: 2989 flesch: 62 summary: Cytotoxicity study of pyrazole derivatives. The IC50 values of pyrazole derivatives having two nitro groups (Uddin, 2000) and two bromo groups at 2′,4′- positions of benzene ring in series 1 and 2 respectively are compared in Table III. keywords: br br; compounds; ic50; pyrazole cache: bjp-575.pdf plain text: bjp-575.txt item: #799 of 942 id: bjp-57593 author: Sookaromdee, Pathum; Wiwanitkit, Viroj title: Cost-effectiveness analysis of intradermal versus classical intramuscular COVID-19 vaccine administration date: 2022 words: 928 flesch: 36 summary: Intradermal administration was therefore offered as a good technique to provide reciprocal doses while redu- cing vaccine cost and quantity necessary (Intapiboon et al., 2021). The cost per effectiveness of each COVID19 vaccine administration is calculated, and the cost-effectiveness value of vaccine administration is compared. keywords: cost; covid-19; effectiveness; vaccine cache: bjp-57593.pdf plain text: bjp-57593.txt item: #800 of 942 id: bjp-576 author: Laizu, Jahanara title: Speciation of arsenic in vegetables and their correlation with inorganic phosphate level date: 2007 words: 4431 flesch: 56 summary: I Concentration of total arsenic in different types of vegetables (n= 20, each) Total arsenic Total arsenic Inor- ganic arsenic Inor- ganic arsenic MMA MMA DMA DMA Inor- ganic phos- phate Inor- ganic phos- phate Fruiting vegetables Range Mean ± SD Range Mean ± SD Range Mean ± SD Range Mean ± SD Range Mean ± SD Parble 0.0‑8.3 3.2 ± 2.9 0.0‑3.2 1.3 ± 1.2 0.0‑2.8 1.1 ± 0.9 0.0‑3.2 0.9 ± 1.1 0.3‑2.1 0.9 ± 0.4 Papaya 0.0‑7.2 2.4 ± 2.3 0.0‑1.5 0.5 ± 0.5 0.0‑3.1 0.8 ± 0.9 0.0‑2.8 1.1 ± 1.0 0.0‑2.3 1.0 ± 0.5 Bean 0.0‑7.4 2.2 ± 1.9 0.0‑2.2 0.6 ± 0.6 0.0‑4.6 0.7 ± 1.1 0.0‑2.2 0.8 ± 0.7 0.2‑1.3 0.7 ± 0.3 French bean 0.3‑3.7 2.1 ± 1.0 0.0‑2.1 0.8 ± 0.6 0.0‑0.8 0.5 ± 0.3 0.0‑1.6 0.8 ± 0.5 0.8‑2.7 1.4 ± 0.6 Brinjal 0.0‑7.2 1.7 ± 2.0 0.0‑3.0 0.8 ± 1.0 0.0‑1.9 0.3 ± 0.4 0.0‑4.4 0.7 ± 1.1 0.9‑5.7 2.0 ± 1.2 Bitter gourd 0.0‑9.8 1.5 ± 2.2 0.0‑2.5 0.4 ± 0.6 0.0‑3.9 0.5 ± 0.7 0.0‑3.4 0.5 ± 0.8 0.8‑4.6 2.2 ± 1.2 Lady's fin- ger 0.1‑4.9 1.4 ± 1.2 0.0‑2.1 0.7 ± 0.6 0.0‑1.0 0.3 ± 0.4 0.0‑3.5 0.4 ± 0.8 0.3‑3.3 1.4 ± 0.9 Pumpkin 0.0‑7.3 1.4 ± 1.5 0.0‑2.2 0.7 ± 0.6 0.0‑2.9 0.3 ± 0.7 0.0‑2.3 0.3 ± 0.6 0.8‑2.1 1.4 ± 0.5 Cauliflower 0.1‑3.6 0.8 ± 0.8 0.0‑1.4 0.4 ± 0.5 0.0‑0.6 0.2 ± 0.2 0.0‑1.6 0.2 ± 0.3 0.3‑2.0 0.6 ± 0.4 Tomato 0.1‑1.5 0.7 ± 0.5 0.0‑1.0 0.3 ± 0.3 0.0‑0.4 0.1 ± 0.1 0.0‑0.5 0.3 ± 0.2 0.0‑0.6 0.4 ± 0.1 Root and tuber vege- tables Arum 1.0‑7.7 3.9 ± 1.7 0.0‑3.4 1.5 ± 0.9 0.1‑2.3 0.8 ± 0.7 0.0‑2.9 1.6 ± 1.0 0.7‑2.9 1.8 ± 0.7 keywords: arsenic; arum; bangladesh; dma; inorganic; phosphate; relationship; vegetables cache: bjp-576.pdf plain text: bjp-576.txt item: #801 of 942 id: bjp-57727 author: Sundar, Ranjitha Dhevi V.; Arunachalam, Sathiavelu title: Anti-MRSA activity of Pollianthes tuberosa leaf extracts date: 2022 words: 1772 flesch: 52 summary: Bangladesh Journal of Pharmacology Volume: 17; Number 1; Year 2022 Cite this article as: Sundar RDV, Arunachalam S. Anti-MRSA activity of Pollianthes tuberosa leaf extracts. Plants with medicinal properties have been studied in different parts of the world as a cure for numerous ailments (Ravi et al., 2020). keywords: activity; aureus; extracts cache: bjp-57727.pdf plain text: bjp-57727.txt item: #802 of 942 id: bjp-57734 author: Jiang, Xia; Xie, Jie; Hu, Zhaotun; Xiang, Xiaoliang title: Ethanol extract of Poria cocos induces apoptosis and differentiation in Neuro-2a neuroblastoma cells date: 2022 words: 5007 flesch: 56 summary: Transcriptome analysis revealed that the cell cycle as the potential primary target pathway of the extract in Neuro-2a cells. Furthermore, the extract also induced apoptosis in Neuro-2a cells. keywords: analysis; apoptosis; cells; cocos; cycle; differentiation; extract; figure; hours; neuro-2a; neuro-2a cells; neuroblastoma; p. cocos cache: bjp-57734.pdf plain text: bjp-57734.txt item: #803 of 942 id: bjp-58188 author: Wang, Jian; Gao, Xuefeng title: Sesquiterpene compound α-cyperone relieves the injury in neurons undergoing oxygen-glucose deprivation/reoxygenation date: 2022 words: 4845 flesch: 55 summary: First of all, our experi- mental results revealed that α-cyperone with the highest experimental concentration of 30 μM did not harm the viability of PC12 cells, and could reduce the damage to cell viability following the cells were stimulated by OGD/R. Figure 1: α-Cyperone reduces OGD/R-induced damage to neuronal viability and alleviates inflammation. Results Effects on neuronal viability and inflammation The effect of gradient concentrations of α-cyperone on PC12 cell viability was determined using a CCK-8 assay. keywords: cells; cyperone; figure; foxo1; levels; ogd; sirt3; stroke; treatment; typ; viability; wang cache: bjp-58188.pdf plain text: bjp-58188.txt item: #804 of 942 id: bjp-58728 author: Gatphoh, Banylla Felicity Dkhar ; Naval Aggarwal, Natasha ; Kumar, S. Madan ; Kumar, M. Vijay ; Revanasiddappa, B. C. title: Synthesis, in silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives date: 2022 words: 4980 flesch: 60 summary: Bangladesh Journal of Pharmacology Research Article Synthesis, in silico analysis and antidepressant activity of 1,3,4- oxadiazole derivatives BJP Introduction 1,3,4-Oxadiazoles are an important class of compounds in medicinal chemistry because of their interesting diversified biological applications (Arshad et al., 2014). Synthesis, in silico analysis and antidepressant activity of 1,3,4- oxadiazole derivatives Banylla Felicity Dkhar Gatphoh1, Natasha Naval Aggarwal1, S. Madan Kumar1, M. Vijay Kumar2 and B. C. Revanasiddappa1 1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte - Deemed to be University, Paneer, Deralakatte, Bangalore 575018, Karnataka, India; 2 Institue of Excellence, Vijnana Bhavan, University of Mysore, Mysuru 570006, Karnataka, India. keywords: activity; antidepressant; bangladesh; compounds; derivatives; mice; oxadiazole; synthesis; test cache: bjp-58728.pdf plain text: bjp-58728.txt item: #805 of 942 id: bjp-59115 author: Gaikwad, Ravindra; Nadaf, Sameer; Shinde, Anilkumar title: Anti-inflammatory activity of Memecylon malabaricum date: 2022 words: 1494 flesch: 51 summary: Anti-inflammatory activity of Memecylon malabari- cum. Anti-inflammatory activity of Memecylon malabaricum Sir, Recently, herbal medicines have received attention because of their ease of availability, minimum severe adverse effects, and safer treatment of ample illnesses. keywords: activity; bangladesh; extract; leaves; malabaricum cache: bjp-59115.pdf plain text: bjp-59115.txt item: #806 of 942 id: bjp-5921 author: Buang, Yohanes; Ola, Pius D.; Yanagita, Teruyoshi title: Dietary shochu kasu alleviates fatty liver induced by orotic acid date: 2010 words: 3340 flesch: 55 summary: The slightly decreased final body weight of shochu kasu-containing group than that of orotic acid group might be contributed by the reduction of white adipose tissues weight, mainly omental and perirenal {(omental; orotic acid + shochu kasu, 1.23 ± 0.02; orotic acid, 1.42 ± 0.07) (perirenal; orotic acid + shochu kasu, 0.66 ± 0.07; orotic acid, 0.96 ± 0.12)}. Furthermore, dietary orotic acid promoted liver weight significantly than that of the basal group. keywords: acid; fatty; kasu; liver; rats; shochu; synthase; triglyceride cache: bjp-5921.pdf plain text: bjp-5921.txt item: #807 of 942 id: bjp-59258 author: Badaoui, Majda; Moubtakir, Soad; Terrafe, Chafik; Aboufatima, Rachida; Chait, Abderrahman title: Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera date: 2022 words: 6639 flesch: 55 summary: Animals were randomly divided into different 8 or 6 groups of 6 animals each: Control group (treated with vehicle), E. resinifera groups (treated with 25, 50, and 75 mg/kg of latex extract). One-way ANOVA followed by Tukey’s post hoc test Figure 3: Aqueous latex extract of E. resinifera effect and diazepam (2 mg/kg) in open field test (A, C) and thiopental-induced sleeping test (B, D) in mice (n=6/group). keywords: animals; antidepressant; antioxidant; bangladesh; control; diazepam; effect; extract; latex; pharmacol; resinifera; test; time cache: bjp-59258.pdf plain text: bjp-59258.txt item: #808 of 942 id: bjp-59408 author: Gaikwad, Ravindra; Shinde, Anilkumar title: Antiproliferative effect of Memecylon malabaricum leaves methanolic extract against A-431 cell lines date: 2022 words: 1158 flesch: 48 summary: Antiproliferative effect of Memecylon malabaricum leaves methanolic extract against A-431 cell lines. Antiproliferative effect of Memecylon malabaricum leaves methanolic extract against A-431 cell lines Sir, Psoriasis is a chronic, immune-mediated inflammatory disorder of the skin. keywords: antiproliferative; cell; extract; leaves; malabaricum cache: bjp-59408.pdf plain text: bjp-59408.txt item: #809 of 942 id: bjp-59412 author: Bozkurt, Mehmet Fatih; Bhaya, Muhammad Nasir; Sever, İbrahim Halil ; Özkul, Bahattin ; Erbaş, Oytun title: Medroxyprogesterone acetate improves propionic acid-induced autism rat model and magnetic resonance spectroscopic correlation date: 2022 words: 6243 flesch: 51 summary: The number of ambulation in open field test was found less in propionic acid group compared to control group and propionic acid + medroxyprogesterone group (p<0.05). The levels of IL-17 and IL-2 were also high in propionic acid group compared to control group and propionic acid + medroxyprogesterone group (p<0.05). keywords: acid; acid group; autism; brain; ca1; ca3; control; et al; group; medroxyprogesterone; model; propionic; protein; rats; spectrum cache: bjp-59412.pdf plain text: bjp-59412.txt item: #810 of 942 id: bjp-59418 author: Colluoglu, Cagdas; Balci, Serdar; Gundogdu, Betul; Coban, Taha Abdulkadir ; Bulut, Seval; Suleyman, Halis title: Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat: date: 2022 words: 4522 flesch: 46 summary: In damaged tissues, the oxidant/ Figure 1: Histopathological evaluation of ovarian tissue in experimental groups Ovarian tissue of the normal follicle structures (arrow) and corpus luteum (asterisk), H&E x40 (A). Results Biochemical findings MDA and tGSH analysis results As seen in Table I, MDA levels increased and tGSH levels decreased when cyclophosphamide group was compared with healthy and cyclophosphamide plus thymoquinone (p<0.001). keywords: antioxidant; cyclophosphamide; damage; et al; group; infertility; mda; rats; results; thymoquinone; tissue cache: bjp-59418.pdf plain text: bjp-59418.txt item: #811 of 942 id: bjp-59809 author: Güçlü, Ebru; Çınar Ayan, İlknur ; Vural, Hasibe title: Inhibitory effect of AK-7 mediates by apoptosis, increases DNA fragmentation and caspase-3 activity in human glioblastoma multiforme cells date: 2022 words: 6253 flesch: 60 summary: In this study, the effect of pharmacological inhibition of AK-7, a SIRT2 inhibitor, was investigated in U87 glioblastoma multiforme cells. Colony formation assay The colony formation assay was performed to evaluate the effect of 75 and 100 µM doses of AK-7, on colony forming capacity in U87 glioblastoma multiforme cells. keywords: ak-7; analysis; apoptosis; cancer; cells; dose; effect; et al; expression; glioblastoma; hours; min; multiforme; multiforme cells; sirt2 cache: bjp-59809.pdf plain text: bjp-59809.txt item: #812 of 942 id: bjp-59819 author: Achummantakath, Hashim; Prasanna, Krishnan Subhadra ; Nizamudeen, A. S. title: Effect of Phyllanthus amarus in sodium arsenite-induced tissue damage date: 2022 words: 3494 flesch: 53 summary: Phyllanthus amarus (100 mg/kg; D, H, L) Group IV - Sodium arsenite (40 mg/kg) + P. amarus (200 mg/kg). The regenerative effect of P. amarus extract is possibly due to the presence of various phytoconstituents present in the ethanolic extract. keywords: amarus; arsenic; extract; group; rats; sodium; tissue cache: bjp-59819.pdf plain text: bjp-59819.txt item: #813 of 942 id: bjp-60353 author: Balcik-Ercin, Pelin title: Eckol, a potential inhibitor of aryl hydrocarbon receptor, inhibits proliferation and induces apoptosis in breast cancer cells date: 2022 words: 4949 flesch: 57 summary: Effect of eckol on apoptosis in breast cancer cell lines After the determination of the cell proliferation role of eckol on breast cancer cell models, we assessed whether the observed cellular growth inhibition by eckol treat- ment was accompanied by apoptotic death in two Table Bangladesh Journal of Pharmacology Research Article Eckol, a potential inhibitor of aryl hydrocarbon receptor, inhibits proliferation and induces apoptosis in breast cancer cells BJP Introduction Breast cancer is the most common cancer type in female populations and the second cancer-related death world- wide (Bray et al., 2018). keywords: ahr; br-3; breast; breast cancer; cancer; cell; eckol; hours; mb-231; mda; proliferation; treatment cache: bjp-60353.pdf plain text: bjp-60353.txt item: #814 of 942 id: bjp-60373 author: Tran, Minh Duc; Tran, Trang ; Nguyen, Ngan; Chu, Ha; Nakahama, Taisuke ; Nguyen, Nam title: Anti-inflammatory activity of 9-hydroxycanthin-6-one extracted from hairy-root cultures of Eurycoma longifolia potentially via aryl hydrocarbon receptor induction date: 2022 words: 1823 flesch: 58 summary: This study aimed to accelerate 9-hydroxycanthin-6-one production from E. longifolia hairy root cultures and to test its anti-inflammatory activity in RAW264.7 macrophage cell line. There was growth of hairy root and accumulation of 9- hydroxycathin-6-one in Murashige and Skoog (MS), Shenck and Hildebrandt (SH), and McCown’s woody plant (WP) liquid culture media supplemented with 3% (w/v) of sucrose. keywords: longifolia; nguyen cache: bjp-60373.pdf plain text: bjp-60373.txt item: #815 of 942 id: bjp-60650 author: Kumar, Vishal; Bahuguna, Ashutosh; Kim, Myunghee title: Simultaneous detection and quantification of different biogenic amines date: 2022 words: 2140 flesch: 51 summary: Besides this, the abundance of biogenic amines in food is recognized as a toxin and anti-nutritional element that have several health implications. This visual experiment demonstrates all the critical steps required for the extraction of biogenic amines followed by derivatization and high performance liquid chromatography analysis for the successive detection and quantification of biogenic amines such as histamine, cadaverine, tryptamine, agmatine, putrescine, 2-phenylethylamine, spermine, tyramine, and spermidine. keywords: amines; biogenic; chloride; detection; food; histamine cache: bjp-60650.pdf plain text: bjp-60650.txt item: #816 of 942 id: bjp-61292 author: Song, Bin Bin; Xu, Mao Yi ; Xu, Xiao Fang; Li, Xia; Chen, Ming title: Zoledronic acid inhibits the bone metastasis of breast cancer by repressing exosome-loaded DKK1 date: 2022 words: 5766 flesch: 56 summary: [p<0.05, p<0.01] A B A B C D Bangladesh J Pharmacol 2022; 17: 92-101 99 fy the effects of exosomes derived from cancer cells on the interaction between breast cancer cells and osteo- clasts, exosomes were added into the co-cultural system of RAW264.7 cells and breast cancer cells. Dickkopf 1 (DKK1) was both expressed in breast cancer cells and exosomes isolated from breast cancer cells. keywords: acid; bone; breast; breast cancer; cancer; cancer cells; cells; dkk1; exosomes; expression; mb-453; mda; metastasis; osteoclasts; zoledronic cache: bjp-61292.pdf plain text: bjp-61292.txt item: #817 of 942 id: bjp-61326 author: Liu, Chengling; Gao, Jiayu; Liang, Ying title: Phytochemistry, pharmacology and toxicology of Peganum harmala date: 2022 words: 11526 flesch: 54 summary: Harmine can inhibit the growth of various types of cancer cells, such as gastric cancer (Li et al., 2017), lung cancer (Shen et Bangladesh J Pharmacol 2022; 17: 124-140 125 al., 2018), melanoma (Hamsa and Kuttan, 2011a & b), colon cancer (Liu et al., 2016), leukemia (Wang et al., 2015b) and cervical cancer cells (Ayoob et al., 2017). The anti-cancer mechanisms of harmine may contribute to the induced apoptotic and autophagic death of cancer cells through the reduced expression of both p-Akt/Akt and p-mTOR/mTOR and the enhanced phosphoryla- tion of adenosine monophosphate-activated protein kinase (Li et al., 2017; Liu et al., 2016). keywords: activities; activity; alkaloids; anti; bangladesh; cancer; candida; carboline; cell; coli; effects; et al; extract; harmala; harmaline; harmine; ic50; inhibition; liu; liu et; mice; ml escherichia; p. harmala; peganum; pharmacol; protein; seeds; virus; wang; wang et; zhang cache: bjp-61326.pdf plain text: bjp-61326.txt item: #818 of 942 id: bjp-62126 author: Terrafe, Chafik; Aboufatima, Rachida; Badaoui, Majda; Laaradia, Mehdi Ait; Kabdy, Hamid; Chait, Abderrahman title: Neuropharmacological effects of Pistacia lentiscus and its possible mechanisms of action date: 2022 words: 5593 flesch: 52 summary: Abstract The objectives of the study were to investigate the analgesic, antianxiety and sedative effects of Pistacia lentiscus essential oil from fruits in mice. The administration of essential oil increased the latency of sleeping and extended time of sleeping in the thiopental test. keywords: diazepam; effect; lentiscus; oil; test; time cache: bjp-62126.pdf plain text: bjp-62126.txt item: #819 of 942 id: bjp-62162 author: V. Sundar, Ranjitha Dhevi; Arunachalam, Sathiavelu title: Tradescantia pallida, a natural alternative against vancomycin-resistant Enterococci date: 2022 words: 1431 flesch: 47 summary: root (C) Table I Antibacterial efficacy of plant extracts (mg/mL) Extracts Inhibition zone (mm) Vancomycin-resistant Enterococcus E. faecalis Vancomycin (positive control) 50 75 100 50 75 100 (30 mg/disc) Stem 6 Dichloromethane - 10 12 12 15 18 Ethyl acetate 11 14 19 13.5 16 18 Butanol - - - - 11 15 Root Dichloromethane - 6 8.5 6 9 12 Ethyl acetate 10 12 13 15 19 22 Butanol - - - - - 12 Table II MIC of plant crude extracts (mg/mL) Organisms Stem Root Dichloromethane Ethyl acetate Dichloromethane Ethyl acetate Vancomycin-resistant Enterococcus 25 6.25 50 12.5 E. faecalis 3.12 3.12 25 1.56 Vancomycin 50 some selected medicinal plants of Pakistan. keywords: extracts; pallida; vancomycin cache: bjp-62162.pdf plain text: bjp-62162.txt item: #820 of 942 id: bjp-62233 author: AbdRabou, Mervat; Al- Otaibi, Aljohara title: Morphological and histopathological alterations caused by meloxicam in chick fetuses date: 2022 words: 3525 flesch: 57 summary: The application of different doses of meloxicam post 12 day of incubation in the present study established that A B C D E Figure 2: Photographs of chick fetuses after 48 hours of meloxicam injection. Bangladesh Journal of Pharmacology Research Article Morphological and histopathological alterations caused by meloxicam in chick fetuses BJP Introduction keywords: cells; chick; control; embryo; fetuses; group; meloxicam; study cache: bjp-62233.pdf plain text: bjp-62233.txt item: #821 of 942 id: bjp-62273 author: Rana, Vijay Singh ; Sethiya, Neeraj Kumar; Singhal, Manmohan title: Anti-diabetic activity of Allium wallichii on streptozotocin-nicotinamide-induced type-2 diabetes in rat date: 2022 words: 3684 flesch: 50 summary: Group IV and Group V rats were treated with A. wallichii extract at a dose (200 or 400 mg/kg) followed by glucose. Group IV and Group V rats were treated with A. wallichii extract at a dose (200 or 400 mg/kg) followed by streptozotocin-nicotinamide. keywords: allium; diabetes; et al; extract; glucose; nicotinamide; rats; streptozotocin; type-2; wallichii cache: bjp-62273.pdf plain text: bjp-62273.txt item: #822 of 942 id: bjp-62376 author: Luo, Mansheng; Zeng, Yanmei ; Deng, Xiaoling title: 15,16-Dihydrotanshinone I inhibits the proliferation of MV4-11 by means of apoptosis via antagonizing FLT3-ITD/STAT5/Mcl-1 pathway date: 2023 words: 4087 flesch: 53 summary: In acute myeloid leukemia cells, FLT3-ITD mutation is considered to constitutively activate this mutant tyro- sine kinase through self-dimerization and ensuing phosphorylation (Kiyoi et al., 1998). Till now, the medicines approved for acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) dis- play not ideal efficacy. keywords: acute; apoptosis; cells; dihydrotanshinone; flt3; itd; leukemia; mcl-1; mv4; myeloid; stat5 cache: bjp-62376.pdf plain text: bjp-62376.txt item: #823 of 942 id: bjp-62627 author: Interino, Jawhar O.; Alombro, Nancy C.; de Vera, Peter Jan D. title: Cytotoxic activity of Centrosema molle leaf aqueous extracts date: 2023 words: 1619 flesch: 59 summary: This preliminary study will help establish the dosage or concentration that will be used for future studies involving the biological activities of C. molle extract in both in vitro and in vivo setups. C. molle extract was prepared by suspending 30 g of C. molle leaf powder in 100 mL of deionized water, then was heated at a 60°C water bath (Thermo Fisher Scientific, USA). keywords: brine; concentration; extract; molle; percent cache: bjp-62627.pdf plain text: bjp-62627.txt item: #824 of 942 id: bjp-62725 author: Han, Yohan; Eom, Young Seok; Shah, Fahad Hassan; Kim, Song Ja title: Destabilising microtubule polymerization regulates chondrocyte dedifferentiation and inflammation via nuclear factor kappa b and β-catenin pathway date: 2023 words: 5122 flesch: 45 summary: Additionally, colchicine stimulated β-catenin overexpression, which is characterized by the accumulation of β-catenin into the cytosol determined by immunofluorescence staining. In the absence of Wnt ligand protein, β-catenin is phos- phorylated by the GSK3 complex (Huang et al., 2019). keywords: catenin; cells; chondrocytes; colchicine; collagen; differentiation; expression; figure; osteoarthritis; pathway; tubulin cache: bjp-62725.pdf plain text: bjp-62725.txt item: #825 of 942 id: bjp-62914 author: V. Sundar, Ranjitha Dhevi; Arunachalam, Sathiavelu title: Effect of endophytic fungi Daldinia eschscholtzii against multidrug resistant pathogens date: 2023 words: 3833 flesch: 51 summary: Antibacterial activities of endophytic fungi isolated from six Sri Lankan plants of the family Cyperaceae. Bangladesh Journal of Pharmacology Research Article Effect of endophytic fungi Daldinia eschscholtzii against multidrug resistant pathogens BJP Introduction Natural products are most likely to afford a wide range of difficult-to-synthesize structures, making them the prospective sources of novel antibiotic classes (Bate et al., 2020). keywords: acetate; activity; atcc; bangladesh; endophytic; eschscholtzii; ethyl; extract; fungi; pharmacol cache: bjp-62914.pdf plain text: bjp-62914.txt item: #826 of 942 id: bjp-63052 author: Shiu, Polly Ho-Ting; Zheng, Chengwen; Rangsinth, Panthakarn ; Wang, Wen; Li, Jingjing; Li, Renkai; Leung, George Pak-Heng title: Anti-inflammatory effect of gallic acid on HaCaT keratinocytes through the inhibition of MAPK-, NF-kB-, and Akt-dependent signaling pathways date: 2023 words: 5736 flesch: 56 summary: Gallic acid (30 µM) did not affect the total and phosphorylated JNK Figure 3: Effects of gallic acid on total and phosphorylated protein levels of MEK1/2, ERK1/2, JNK and p38 MAPK in HaCaT keratinocytes. Gallic acid is a naturally occurring tri-phenolic com- pound found in various plants, with a particularly high abundance in gallnuts, witch hazel, oak bark, tea leaves, areca nut, bearberry, and blackberry. keywords: acid; akt; cells; control; expression; gallic; gallic acid; hacat; ifn; keratinocytes; levels; protein; tnf cache: bjp-63052.pdf plain text: bjp-63052.txt item: #827 of 942 id: bjp-63307 author: Madhusudan, Thorati; Chander, M. Punnam title: GC-MS analysis and in vitro antibacterial activities of mangrove endophytic fungi date: 2023 words: 2269 flesch: 53 summary: GC- MS analysis revealed bioactive compounds from five fungal strains, and each compound has been struc- Bangladesh J Pharmacol 2023; 18: 36-39 37 Table I Antibacterial activity of endophytic fungi isolated from mangrove roots Bacterial pathogen Activity of endophytic fungal extracts (in mm) A. terreus C. lunata N. clavispora P. oxalicum F. equiseti S. aureus 15.3 ± 0.6 11.3 ± 0.6 9.7 ± 0.6 14.3 ± 0.6 17.3 ± 0.6 M. luteus 14.0 ± 1.0 10.3 ± 0.6 _ 20.3 ± 0.6 16.3 ± 1.2 E. faecalis 17.3 ± 0.6 13.7 ± 0.6 12.7 ± 0.6 12.7 ± 1.2 15.0 ± 0.0 V. cholera 20.0 ± 0.0 12.3 ± 1.2 10.7 ± 0.6 17.0 ± 0.0 21.3 ± 1.5 P. aeruginosa 15.7 ± 0.6 _ _ 11.7 ± 1.2 20.7 ± 0.6 P. mirabilis 20.0 ± 1.0 12.7 ± 0.6 _ 12.7 ± 0.6 18.0 ± 1.0 S. typhi 22.7 ± 0.6 15.0 ± 0.0 17.7 ± 0.6 20.7 ± 1.2 22.0 ± 1.7 S. dysentery type S 12.3 ± 0.6 9.7 ± 0.6 11.0 ± 0.0 12.3 ± 0.6 22.7 ± 0.6 Enterotoxigenic E. coli serotype 0115 19.3 ± 0.6 11.7 ± 1.2 11.3 ± 1.2 15.0 ± 0.0 25.0 ± 1.0 V. fluvialis 20.7 ± 0.6 18.0 ± 1.0 _ 22.3 ± 1.53 20.3 ± 0.6 Table II Gene bank accession number of endophytic fungal strains Endophytic fungal strain Gene bank number NCBI DNA sequences Sequence identity (%) GC-MS analysis and in vitro antibacterial activities of mangrove endophytic fungi. keywords: compounds; fungi; mangrove; metabolites cache: bjp-63307.pdf plain text: bjp-63307.txt item: #828 of 942 id: bjp-64228 author: Rokkarukala, Samson; Chander, M. Punnam; Mohanraju, Raju title: GC-MS analysis and antibacterial properties of the selected soft corals from South Andaman, India date: 2023 words: 1850 flesch: 50 summary: Long utilized as sources of various natural chemicals with pharmacological or aesthetic value include a wide range of reef invertebrates, including soft corals (Chao et al., 2011). Soft corals are a highly diverse group of marine orga- nisms that contain a rich source of secondary meta- bolites. keywords: acid; compounds; corals; methyl cache: bjp-64228.pdf plain text: bjp-64228.txt item: #829 of 942 id: bjp-64676 author: Shankar, Saranya; Ravi, Narmadha Devi ; Sathiavelu, Mythili title: Antibacterial activity of Calathea insignis date: 2023 words: 1408 flesch: 53 summary: By using a sterile cork borer, wells were made in the agar plates and loaded with 100 µL of leaf extract at different concentrations (100, 50, Sethi S, Khanna S, Khan A, Hatti N. Evaluation of antimicro- bial and antioxidant activity of leaf extracts of medicinal plants. keywords: activity; extracts; leaf; plant cache: bjp-64676.pdf plain text: bjp-64676.txt item: #830 of 942 id: bjp-64690 author: Segaran, Gayathri; Srinivasan, Chitashalini; Sathiavelu, Mythili title: Antibacterial activity of Calathea anulque date: 2023 words: 1310 flesch: 50 summary: About 5 mL of distilled water was added to the test tube containing plant extract, and the contents were vigorously shaken. The growth of Corynebacterium diphtheriae and S. aureus was inhibited by methanolic extracts of ornamental plants such as Dieffenbachia spp. keywords: activity; anulque; extracts cache: bjp-64690.pdf plain text: bjp-64690.txt item: #831 of 942 id: bjp-65135 author: Aitbaba, Abdelfatah; Sokar, Zahra; Chait, Abderrahman title: Analgesic and anti-inflammatory effects of hydroalcoholic extract of Astragalus ibrahimianus date: 2023 words: 5602 flesch: 57 summary: A literature search on free radical scavenging in A. ibrahimianus has not been reported elsewhere, but previous studies on different Astragalus species have reported significant antioxidant activity from these plants (Butkutė et al., 2018; Teyeb et al., 2012). The study aimed to investigate whether the hydroalco- holic extract of the aerial part of A. ibrahimianus, which has never been investigated, possesses potential biological activities. keywords: acid; activity; antioxidant; astragalus; control; edema; extract; ibrahimianus; min; paw; test cache: bjp-65135.pdf plain text: bjp-65135.txt item: #832 of 942 id: bjp-65531 author: Turker, Nebiye Pelin; Bakar, Elvan title: Effects of L-dopa and p-coumaric acid combination on oxidative stress, DNA damage, and mitochondrial apoptosis in neuroblastoma cells date: 2023 words: 5521 flesch: 58 summary: Financial Support Self-funded Ethical Issue The development, acquisition, authentication, cryopreserva- tion, and transfer of cell lines between laboratories were followed according to the guidelines published in British Journal of Cancer, 2014 Conflict of Interest Authors declare no conflict of interest Acknowledgement The authors would like to acknowledge Trakya University Technology Research Development Application and Research Center References Adamczyk B, Tharmalingam T, Rudd PM. Characteristics of cell lines established from human gastric carcinoma. keywords: acid; apoptosis; application; cell; control; dopa; dopamine; fold; gene; n1e-115; neuroblastoma; step; stress cache: bjp-65531.pdf plain text: bjp-65531.txt item: #833 of 942 id: bjp-6582 author: Umamaheswari, Muthuswamy; Asokkumar, Kuppuswamy; Sivashanmugam, Thirumalaiswamy; Subhadradevi, Varadharajan; Neethu, Michael title: Anticataract activity of Erythrina stricta against naphthalene-induced cataractogenesis in rats date: 2010 words: 3531 flesch: 57 summary: Normal sa- line 10 mL/kg 0.7 ± 0.0 78.4 ± 2.7 Naphthalene control 1 g/kg 2.0 ± 0.3a 45.3 ± 2.2a Petroleum ether fraction 200 mg/kg 1.0 ± 0.1b 64.7 ± 1.9b Results are expressed as mean ± SEM from six rats in each group. keywords: cataract; control; fraction; naphthalene; protein; stage; stricta cache: bjp-6582.pdf plain text: bjp-6582.txt item: #834 of 942 id: bjp-65836 author: Settu, Sugashini; Arunachalam, Sathiavelu title: Anti-diabetic effect of Daldinia eschscholtzii and Phomopsis mangiferae isolated from Bryophyllum pinnatum date: 2023 words: 8482 flesch: 57 summary: These findings on anti-diabetic activity of known and unknown species of endophytic fungi are in agreement with the previous study reports. These finding provides evidence that D. eschscholtzii and P. mangiferae are potent endophytic fungi having anti-diabetic activity. keywords: acetate; activity; antioxidant; cell; crude; endophytic; eschscholtzii; et al; ethyl; extracts; fungal; fungi; glucose; inhibition; pinnatum; uptake; yeast cache: bjp-65836.pdf plain text: bjp-65836.txt item: #835 of 942 id: bjp-65860 author: Anwaar, Mariya; Jabeen, Qaiser ; Ali, Hina; Nadeem, Ayesha ; Rasheed, Hafiz Muhammad Farhan title: Vigna mungo possesses pharmacological potential for the management of hyperthyroidism and improves estrus cycle disturbances date: 2023 words: 6634 flesch: 52 summary: Plants with reported antithyroid activity include Aegle marmelos, Aloe vera (Kar et al., 2002), Allium sativum, Trigonella foenum-graecum (Tahi- liani and Kar, 2003), Althaea officinalis (Shah et al., 2011), Carica papaya (Udoh et al., 2004), Melissa officinalis, Lyco- pus europaeus, Rosmarinus officinalis, Salvia officinalis and Bacopa monnieri (Singh et al., 2021). 2011 Glycosides 500 mg extract + 2 mL chloroform + 2 mL of concen- trated H2SO4 Reddish brown color Audu et al., 2007 Phenols Extract solution, filtered, filtrate + 5% ferric chloride solution Bluish black precipitates Mandal et al., 2013 Phlobatannins 500 mg extract + 2 mL of distilled water, boiled on water bath + HCl (2%) Red color precipitates Jana and Shekhawat, 2010 Quinones 100 mg extract + concentrated HCl Yellow color precipitates Ugochukwu et al., 2013 Resins 200 mg extract + 5 mL ethanol, poured resulting solu- tion in 10 mL of distilled water Precipitates Velavan, 2015 Saponins Boiling water + 500 mg extract, cooled and then shak- en vigorously Froth formation Zohra et al., 2012 Tannins 500 mg extract + 10 mL distilled water + gelatin solu- tion (1%) (having 10% sodium chloride) White precipitates Tiwari et al., 2011 Terpenes Extract + copper acetate solution (1%) Emerald green color keywords: body; carbimazole; desktop; diestrus; estrus; extract; file:///c:/users; levels; mungo; phase; rats; study; thyroid; thyroxine cache: bjp-65860.pdf plain text: bjp-65860.txt item: #836 of 942 id: bjp-65992 author: Gogoi, Nabajyoti; Gogoi, Ankur; Neog, Bijoy; Singh, Khumanthem Deepak title: Hepatoprotective effect of Garcinia xanthochymus and Garcinia lanceifolia against carbon tetrachloride-induced hepatic damage in rat date: 2023 words: 3351 flesch: 51 summary: The histopathological observation confir- med that G. xanthocymus rind extract was more potent than G. lanceifolia extract towards the liver protection damage by carbon tetrachloride (Figure 2D-G). Hepatoprotective activity of Terminlia arjuna leaf against paracetamol induced liver damage in rats. keywords: activity; carbon; extract; garcinia; group; hepatoprotective; liver cache: bjp-65992.pdf plain text: bjp-65992.txt item: #837 of 942 id: bjp-66459 author: Islamoglu, Nesim; Demir Mulazımoglu, Aysen title: Use of guanine-modified glassy carbon electrode as an electrochemical sensor for the determination of paracetamol date: 2023 words: 4922 flesch: 53 summary: Uzun D, Calam T. Electrochemical behavior and ultrasensitive, simple and effective voltammetric determination of acetami- nophen using modified glassy carbon electrode based on 4- hydroxyquinoline-3-carboxylic acid. Bangladesh J Pharmacol 2023; 18: 97-104 103 Author Info Ayen Demir Mulazımoglu (Principal contact) e-mail: admulazimoglu@erbakan.edu.tr Mohamed E, Mahmoud A, Nashat N, El‑Mosallamy S. Fabri- cation of novel electropolymerized conductive polymer of hydrophobic perfuorinated aniline as transducer layer on glassy carbon electrode: keywords: carbon; determination; electrochemical; electrode; et al; glassy; mulazımoglu; paracetamol; peak; rate; sensor cache: bjp-66459.pdf plain text: bjp-66459.txt item: #838 of 942 id: bjp-6666 author: Shahriar, Iram; Sobhan, Shahina; Islam, Ziarrat title: Troponin I level in risk stratification of non-ST-elevation myocardial infarction in smokers date: 2011 words: 1586 flesch: 54 summary: Smokers showed higher major cardiac events (71.8%) compared to non-smokers (10.8%). Cardiac troponin keywords: infarction; myocardial; non; smoker; troponin cache: bjp-6666.pdf plain text: bjp-6666.txt item: #839 of 942 id: bjp-6671 author: Khan, Nisar Ahmad; Kumar, Dinesh; Bhat, Zulfiqar Ali; Kumar, Vijender; Nagpal, Navneet; Bhujbal, Santosh S. title: In vitro H1-receptor antagonist activity of methanolic extract of tuber of Stephania glabra date: 2011 words: 1925 flesch: 57 summary: %Contraction of isolated guinea pig ileum None Methanol extract (100 µg/mL) The stimulation of H1-receptors produces graded dose-related contraction of isolated guinea pig ileum. keywords: activity; extract; goat; guinea; histamine; pig cache: bjp-6671.pdf plain text: bjp-6671.txt item: #840 of 942 id: bjp-67165 author: Oubella, Khadija ; Benrazzouk, Karima ; Bagri, Abdellah ; Chait, Abderrahman title: Effect of Cuminum cyminum and Rhus pentaphylla extracts on status epilepticus induced by intrahippocampal injection of kainic acid in rat date: 2023 words: 5475 flesch: 52 summary: Table II IC50 (µg/mL) values DPPH FRAP Cuminum cyminum 180.4 ± 0.3 252.0 ± 0.3 Rhus pentaphylla 21.1 ± 0.9 106.1 ± 0.3 Butylatedhydroxytoluene 3.8 ± 0.1 1.0 ± 0.0 Quercetin 1.3 ± 0.0 1.5 ± 0.0 Tonic extension phase Tonic flexion phase Clonic flexion phase Kainic acid (µg/L) 1 1 1 1 1 1 1 1 1 Cc (mg/kg) 300 300 300 300 300 300 300 300 300 Rp (mg/kg) 300 300 300 300 300 300 300 300 300 Figure 1: Different phases of tonico-clonic seizures caused by administration of kainic acid (upper row); Effect of oral pretreat- ment with total extract of C. cyminum (Cc) (300 mg / kg) and R. pentaphylla (300 mg / kg) on the score of seizures induced by in- trahippocampal kainic acid injection (lower row). Results Yield of plant extracts C. cyminum extract yielded 26.8% whereas R. pentaphylla yielded 22%. keywords: acid; activity; antioxidant; cyminum; effects; et al; extract; flavonoids; kainic; pentaphylla; seizures cache: bjp-67165.pdf plain text: bjp-67165.txt item: #841 of 942 id: bjp-67311 author: Maher, Rawan A. ; Alombro, Nancy C.; de Vera, Peter Jan D. title: Anti-angiogenic activity of Centrosema molle leaf aqueous extract date: 2023 words: 1727 flesch: 59 summary: Results showed that all the concentrations of C. molle leaf aqueous extract except 50 µg/mL were able to inhibit the branching points of blood vessels in CAM during the experiment (Figure 1). Some medicinal plant species of Asamagbe stream bank vegetation, forestry Bangladesh J Pharmacol 2023; 18: 116-118 117 Figure 1: Anti-angiogenic effects of different C. molle leaf aqueous extract using CAM assay (n = 63) keywords: activity; cam; extract; leaf; molle cache: bjp-67311.pdf plain text: bjp-67311.txt item: #842 of 942 id: bjp-67354 author: Pal, Sourav; Mandal, Subhajit ; Firdous, Sayed Mohammed title: Neurobehavioral assessment of seed extract of Swietenia mahagoni on zebrafish model date: 2023 words: 4319 flesch: 57 summary: Conclusion Methanolic extract of S. mahagoni extract may have reduced dopamine expression alongside the up- regulation of 5-HT and GABA seen in these neuro- behavioral findings. Bass SL, Gerlai R. Zebrafish (Danio rerio) responds differen- tially to stimulus fish: The effects of sympatric and allopatric Table I Effect of S. mahagoni extract on different parameter of zebra fish Names Day 1 Day 7 Day 14 Total distance travel open field (cm) keywords: dark; extract; light; test; time; zebrafish cache: bjp-67354.pdf plain text: bjp-67354.txt item: #843 of 942 id: bjp-67429 author: Sawarkar, Hemant Arunrao; Pandey, Ajit Kumar ; Biyani, Kailas R. title: Phytochemicals and therapeutic potentials of Barleria lupulina date: 2023 words: 7573 flesch: 55 summary: [36], verbascoside [37] Kim et al., 2016 Ethyl acetate soluble fraction of aqueous extracts followed by preparative HPLC; LC-MS of extract, 1H and 13C NMR, HRESI- MS, IR and comparative study for known compounds Aerial part 4-Ethyl catechols, 4-methyl catechols, 4-vinyl catechol Senger et al., 2016 Hot aqueous extract; LC-MS Leaf Lavandulifolioside, cistanoside C, tubuloside B, betony- oside A Suhaimy et al., 2021 Microwave assisted extraction with ethanol (varying concentra- tion); UHPLC-QTOF/MS 124 Bangladesh J Pharmacol 2023; 18: 119-129 Table II Iridoids from Barleria lupulina Thus, B. lupulina plant as such can be termed to be containing abundance of glycosidal constituents. keywords: acetyl; activity; anti; barleria; compounds; ester; et al; extract; iridoid; lupulina; methanol; methyl; methyl ester; plant; shanziside; shanziside methyl; study cache: bjp-67429.pdf plain text: bjp-67429.txt item: #844 of 942 id: bjp-6750 author: Maideen, Naina Mohamed Pakkir; Velayutham, Ravichandiran; Manavalan, Gobinath title: Protective role of methanol extract of Phyllanthus polyphyllus against N-nitrosodiethylamine-induced liver tumor in rat date: 2011 words: 2857 flesch: 51 summary: Bangladesh Journal of Pharmacology Research Article Protective role of methanol extract of Phyllanthus polyphyllus against N -nitrosodiethylamine-induced liver tumor in rat BJP Introduction Hepatocellular carcinoma is induced by toxic industrial chemicals, air and water pollutants, food additives and fungal toxins (Peers and Linsell, 1973). The present study is aimed to evaluate the protective role of methanol extract of P. polyphyllus against N-nitrosodiethylamine-induced liver tumor in rats. keywords: cancer; cytochrome; enzymes; extract; liver; methanol; nitrosodiethylamine; polyphyllus cache: bjp-6750.pdf plain text: bjp-6750.txt item: #845 of 942 id: bjp-68145 author: Segaran, Gayathri; Charles, Hannahcharlet; Sathiavelu, Mythili title: Antibacterial activity of Calathea roseopicta date: 2023 words: 1478 flesch: 55 summary: Antibacterial activity of Calathea roseopicta Sir, Calathea roseopicta, also known as the rose-painted calathea, is a member of the Marantaceae plant family and is native to northwest Brazil. This is the first investigation into the phytochemical content and antibacterial activity of C. roseopicta leaves. keywords: activity; extracts; roseopicta cache: bjp-68145.pdf plain text: bjp-68145.txt item: #846 of 942 id: bjp-68901 author: Srivastava, Susmita; Rasool, Mahaboobkhan title: CYT387 restores Th17/Treg cell balance and inhibits mature osteoclast cell formation by regulating SOX-5 signaling in rheumatoid arthritis date: 2023 words: 8673 flesch: 52 summary: ap<0.05; bp<0.01; cp<0.001, compared to arthritis CD4+T cells under Th17 differentiation condition. ap<0.05; bp<0.001, compared to arthritis CD4+T cells under Th17 differentiation condition. keywords: + t; arthritis; bone; cd4 +; cells; cyt387; differentiation; expression; fls; rheumatoid; sil-6r; sox-5; stat-3; th17 cache: bjp-68901.pdf plain text: bjp-68901.txt item: #847 of 942 id: bjp-69267 author: Boudou, Farouk; Sehmi, Abdelghani ; Belakredar, Amal; Zaoui, Oussama title: Synthesis, characterization, antimicrobial activity, and in silico assessment of a novel pyrazoline carboxamide heterocyclic compound date: 2023 words: 6005 flesch: 46 summary: The subsequent step involved the synthesis of pyrazoline carboxamide deri- vative. 154 Bangladesh J Pharmacol 2023; 18: 152-161 http://www.rcsb.org http://imods.chaconlab.org Antimicrobial activity The results showed varying degrees of inhibition against the tested microorganisms at different concen- trations of pyrazoline carboxamide (Table I). keywords: activity; analysis; bangladesh; carboxamide; compound; drug; figure; inhibition; mol; pharmacol; potential; protein; pyrazoline; pyrazoline carboxamide; residues; synthesis cache: bjp-69267.pdf plain text: bjp-69267.txt item: #848 of 942 id: bjp-70296 author: Shankar, Saranya; Srinivasan, Chitrashalini ; Sathiavelu, Mythili title: Anti-diabetic activity of Calathea anulque date: 2024 words: 1654 flesch: 58 summary: Anti-diabetic activity of Calathea anulque Sir, Calathea anulque is commonly known as the rattlesnake plant and originates from the tropical rainforests of South America. One of the plant genera, C. panamensis, exhibits potential anti-diabetic activity using the glucose 6- phosphatase assay and significant anti-radical activity using the DPPH trapping technique (Rodríguez et al., 2008). keywords: activity; antioxidant; anulque; extracts cache: bjp-70296.pdf plain text: bjp-70296.txt item: #849 of 942 id: bjp-70297 author: Kulabas, Necla; Tamniku Guven, Cansu; Duracık, Merve; Bingol Ozakpınar, Ozlem; Kucukguzel, İlkay title: Synthesis, molecular modeling, anti-cancer and COX-1/2 inhibitory activities of novel thiazolidinones containing benzothiazole core date: 2024 words: 9023 flesch: 66 summary: Although it has been reported in many studies that this reaction occurs in the presence of sodium acetate/acetic acid (Jung et al., 2011; Rashid et al., 2014), the sodium methoxide/methanol medium was prefer- red as reported in previous studies (Küçükgüzel et al., 2013; Çakır et al., 2015; Türe et al., 2021). The assay was conducted in duplicate and statistical analysis was carried out using GraphPad Prism 6.1 Software (Kulabaş et al., 2023). keywords: activity; arh; benzothiazole; binding; cancer; chem; compounds; cox-2; derivatives; enzyme; et al; med; nmr; ppm; ring; studies; synthesis; thiazolidin-4; thiazolidinone cache: bjp-70297.pdf plain text: bjp-70297.txt item: #850 of 942 id: bjp-70889 author: Wang, Mengting; Chen, Huixian; Wu, Qian; Huang, Yan ; Zhou, Yuzhen title: Berberine triggers necroptosis of cervical H8 cells by activating receptor-interacting protein kinase 1 date: 2024 words: 5794 flesch: 48 summary: Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Abstract This study aims to investigate the effect of berberine on necroptosis in cervical H8 cells. keywords: apoptosis; berberine; cancer; cells; et al; expression; h8 cells; mlkl; nec-1; necroptosis; protein; ripk1 cache: bjp-70889.pdf plain text: bjp-70889.txt item: #851 of 942 id: bjp-71024 author: Patil, Sudhir S.; Wadkar, Kiran A. title: In vitro anti-cancer activity of Epipremnum aureum date: 2024 words: 3610 flesch: 52 summary: The results add to this body of evidence, demonstrating the efficacy of E. aureum chloroform extract in mitigating cancer progression. These results suggest that chloroform extract of E. aureum is more effective against breast cancer. keywords: aureum; breast; cancer; cell; chloroform; ethanol; extract; mcf-7 cache: bjp-71024.pdf plain text: bjp-71024.txt item: #852 of 942 id: bjp-71069 author: Ma, Jie; Peng, Cong title: Nigella sativa plant extract inhibits the proliferation of MDA-MB-231 breast cancer cells via apoptosis and cell cycle arrest date: 2024 words: 6013 flesch: 62 summary: Similarly, the seed extract of N. sativa was found to suppress the growth of breast cancer cells in vitro (Dilshad et al., 2012). Apoptosis is often disrup- ted within cancer cells, leading to unregulated cell division and tumor development. keywords: apoptosis; breast; cancer; cancer cells; cells; cycle; effects; et al; extract; mb-231; mb-231 cells; mda; n. sativa; nigella; sativa; sativa extract cache: bjp-71069.pdf plain text: bjp-71069.txt item: #853 of 942 id: bjp-7146 author: Das, Adhir Kumar; Rahman, Md. Sayedur title: Prescribing vitamins at primary health care level: Exploration of facts, factors and solution date: 2011 words: 4210 flesch: 45 summary: However, vitamin prescribing has increased significantly without confirmation of specific deficiency or evidence of lack of specific vitamin in the diets of the people (Anonymous, 2006). Prevalence of vitamin prescribing was 30.2, 38.7 and 45.4% and contribution of vitamins in the cost of drugs prescribed in vitamin containing prescription was 27.6, 30.4 and 41.9% at Upazilla Health Complexes (UHC), non-government organizations (NGO) and private practices (PP) respectively. keywords: bangladesh; drug; health; information; intervention; medical; prescribers; prescribing; prescriptions; vitamin cache: bjp-7146.pdf plain text: bjp-7146.txt item: #854 of 942 id: bjp-71704 author: Yulak, Fatih; Keskin, Zekeriya title: A PLK1 inhibitor, RO3280, suppresses proliferation of SNU-16 gastric cancer cells via apoptosis date: 2024 words: 6221 flesch: 60 summary: The purpose of this study was to identify the pathways responsible for the antiprolifera- tive activity of RO3280, a new PLK1 inhibitor, on the SNU-16 cell line generated from gastric cancer cells. This data suggests that cisplatin resistance in gastric cancer cells may result from PLK1 overexpression, and that PLK1 inhibition may be used to decrease resistance and improve treat- ment effectiveness (Chen et al., 2019). keywords: apoptosis; cancer; cells; cleaved; control; damage; dna; effect; et al; gastric; parp; plk1; potential; ro3280; snu-16; study; treatment cache: bjp-71704.pdf plain text: bjp-71704.txt item: #855 of 942 id: bjp-72632 author: Wang, Wanrong; He, Zongmao; Bao, Jiaolin title: Anti-migration activity of four components from dried fruit of Forsythia suspensa date: 2024 words: 2503 flesch: 55 summary: When evaluating the anti-migration activity of a drug in vitro, the ideal condition would be that its dose would only inhibit the migration of cancer cells, with no effect on growth inhibition. A, forsythoside I, forsythoside H, and iso- forsythiaside significantly suppressed migration of cancer cells by 13.2, 4.5, 13.2, and 20.0% at the concen- tration of 20 µg/mL, respectively (Figure 3A,B). keywords: activity; cancer; cells; forsythoside; migration; suspensa cache: bjp-72632.pdf plain text: bjp-72632.txt item: #856 of 942 id: bjp-72739 author: Tran, Thanh Trung ; Tran, Kien Trung ; Kim, Daeyong ; Nguyen, Nam Trung title: Bioactive peptides SL-13R and KS-13 enhance human adipose-derived mesenchymal stem cell proliferation in vitro date: 2024 words: 1957 flesch: 64 summary: The use of bioactive peptides to expand stem cells is urgent- ly needed to increase the number of these cells for clinical applications (Wang et al., 2022). Targeting the aryl hydrocarbon receptor in stem cells to improve the use of food as medicine. keywords: cells; control; genistein; ks-13; sl-13r cache: bjp-72739.pdf plain text: bjp-72739.txt item: #857 of 942 id: bjp-72787 author: Yu, Hao; Mei, Xiaoping; Zhang, Xueming; Qian, Neng; Yu, Qingjiang; Zhou, Hongkun title: SLC39A1 contributes to gemcitabine resistance of pancreatic ductal adenocarcinoma by activating AMPK signaling date: 2024 words: 4650 flesch: 51 summary: , the correlation of SLC39A1 with gemcitabine resistance in pancreatic ductal adenocarcinoma cells was further analyzed. These data identified an unreported correlation of SLC39A1 with the AMPK signaling pathway in the modulation of gemcitabine resistance of pancreatic ductal adenocarcinoma, namely SLC39A1 promoted gemcitabine resistance by activating the AMPK signa- ling pathway in pancreatic ductal adenocarcinoma cells. keywords: adenocarcinoma; adenocarcinoma cells; ampk; bxpc3; cancer; cells; et al; expression; gemcitabine; gemcitabine resistance; pancreatic; resistance; slc39a1 cache: bjp-72787.pdf plain text: bjp-72787.txt item: #858 of 942 id: bjp-72930 author: Zhang, Biao; Fang, Zaojun; Lin, Ying ; Wu, Qian; Chen, Jiaping title: RU.521 protects against neutrophil extracellular traps-induced vascular endothelial injury by inhibiting cGAS/STING pathway date: 2024 words: 3868 flesch: 57 summary: Vascular endothelial injury plays an important role in acute lung injury (Liu et al., 2015), and neutrophils par- ticipate in vascular endothelial cell injury by releasing neutrophil extracellular traps (NETs)(Fei et al., 2024). Recent studies have shown that dsDNA can participate in vascular endothelial injury through the activation of STING pathway during acute lung injury (Zhu et al., keywords: acute; cells; cgas; dsdna; endothelial; injury; lung; lung injury; nets; pathway; patients; ru.521; sting cache: bjp-72930.pdf plain text: bjp-72930.txt item: #859 of 942 id: bjp-7527 author: Dina, Ashrafun Naher; Misbahuddin, Mir title: Randomized double-blind trial to evaluate the effectiveness of topical administration of propylene glycol in arsenical palmar keratosis date: 2011 words: 2956 flesch: 58 summary: In this study, we examined the effectiveness and tolerance of propylene glycol for the treatment of arsenical palmer keratosis. Sixty patients of arsenicosis with palmer keratoses were randomly divided into three groups and different concentrations (15, 30 and 45%) of propylene glycol were applied topically into their palms once at bedtime for eight weeks. keywords: arsenic; bangladesh; glycol; keratosis; patients; propylene; treatment cache: bjp-7527.pdf plain text: bjp-7527.txt item: #860 of 942 id: bjp-75447 author: Sundar, Ranjitha Dhevi V.; Arunachalam, Sathiavelu title: Antibacterial effect of Dracaena indivisa leaf extracts date: 2024 words: 1801 flesch: 49 summary: The minimum inhibitory concentration of the extracts 104 Bangladesh J Pharmacol 2024; 19: 103-105 Figure 1: GC-MS analysis of D. indivisa chloroform extract ranged between 3.12-1.56 µg/mL for chloroform crude extract (Table I). The antibacterial effect of Dracaena plant species such as D. colorama (Sundar et al., 2020), D. victoria (Sundar et al., 2020), D. mahatma (Saranya et al., 2018) and D. marginata (Shiny et al., 2012) have been reported. keywords: activity; bangladesh; extracts cache: bjp-75447.pdf plain text: bjp-75447.txt item: #861 of 942 id: bjp-7592 author: Pandhare, Ramdas Bhanudas; Sangameswaran, B.; Mohite, Popat B.; Khanage, Shantaram G. title: Aqueous extracts of the leaves of Sesbania sesban reduces development of diabetic nephropathy in streptozotocin-induced diabetic rat date: 2011 words: 2865 flesch: 56 summary: Diabetic rats showed severe hyperglycemia with marked increase in proteinuria and albuminuria. Histopathology studies on kidneys of diabetic rats revealed severe increase in mesangial cells and matrix of glomeruli with hyaline thickening of some arteriole wall, resulted from selective albuminuria and proteinuria. keywords: diabetes; diabetic; extract; glucose; rats; sesban cache: bjp-7592.pdf plain text: bjp-7592.txt item: #862 of 942 id: bjp-76379 author: Zhang, Yo; Zhang, Hongmei; Yang, Shanshan; Gao, Xiufeng; Guo, Wenhao title: Prednisone inhibits osteosarcoma cell by regulating the Wnt/β-catenin signaling pathway date: 2024 words: 5267 flesch: 50 summary: To investigate the effect of prednisone on osteosarcoma cells in vitro, CCK8, wound healing, Transwell assays, flow- cytometry, western blot, and ELISA were used to measure cell proliferation, cell migration, cell invasion, cell cycle, cell apoptosis, and the key proteins in Wnt/β-catenin pathway. Migration of osteosarcoma cells To investigate the effect of prednisone on the migration of osteosarcoma cells, human Mg63 osteosarcoma cells and human Saos-2 osteosarcoma cells were cultured in 6-well plates, scratched, and cultured in serum-free medium with prednisone treatment for 48 hours (Figure 2A). keywords: apoptosis; c c; catenin; cells; cisplatin; control; effects; mg63; osteosarcoma; pathway; prednisone; proliferation; treatment; wnt cache: bjp-76379.pdf plain text: bjp-76379.txt item: #863 of 942 id: bjp-76490 author: Zhang, Biao; Zhao, Junkai; Yin, Jiamin; Chen, Jiaping; Xu, Lingqi title: Ginsenoside Rb1 ameliorates neutrophil extracellular traps-induced vascular endothelial damage by suppressing apoptosis date: 2024 words: 3921 flesch: 43 summary: Ginsenoside Rb1 can reduce vascular endothelial injury induced by neutrophil extracellular traps, ginsenoside Rb1 protects vascular endothelium by inhibiting cell apoptosis. Neutrophil extracellular traps can release reactive oxygen species (ROS), which induces oxidative stress in vascular endothelial cells, damages the cell membranes, and causes vascular endothelial dysfunc- tion (Zhou et al., 2024). keywords: apoptosis; cells; damage; endothelial; expression; ginsenoside; injury; neutrophil; rb1; traps; μmol cache: bjp-76490.pdf plain text: bjp-76490.txt item: #864 of 942 id: bjp-76556 author: Liu, Sijie; Zhu, Jiayi; Huang, Hao; Xu, Jiaxiang; Zhang, Biao; Luo, Yi title: Catalpol alleviates the lipopolysaccharide-induced inflammatory response of BV2 cells date: 2024 words: 4338 flesch: 53 summary: Through the microglia regulating Abstract This study aimed to investigate the effect of catalpol on the inflammatory response of murine microglial cell line (BV2 cells) induced by lipopolysaccharide. Therefore, catalpol can inhibit the lipopolysaccharide-induced activation of BV2 cells and has anti-inflammatory effects. keywords: bv2; bv2 cells; catalpol; cells; group; inos; lipopolysaccharide; microglia; neuroinflammation; ros cache: bjp-76556.pdf plain text: bjp-76556.txt item: #865 of 942 id: bjp-7720 author: Rabbani, Md. Golam; Islam, Md. Rabiul; Ahmad, Mesbahuddin; Hossion, Abugafar Md. Lokman title: Synthesis of some NH-derivatives of ciprofloxacin as antibacterial and antifungal agents date: 2011 words: 3852 flesch: 59 summary: IR (cm-1): 3462-2400 (O-H str, H-bonded); 3102 (C-H str. aromatic); 3057 (C-H str.CH2); 2862 (C-H str.CH3); 1722 (C=O acid); 1629 (C=O str. ,H-bonded); 3042 (C-H str. aromatic); 1725 (C=O acid); 1624 (C=O str conjugated keto.); 1498 (C-N str.); 1357 (C-O str.); 1298( C-F str.). keywords: acid; ciprofloxacin; nmr; salmonella; solution; str cache: bjp-7720.pdf plain text: bjp-7720.txt item: #866 of 942 id: bjp-77475 author: Yin, Hao; Zhu, Jiaoli; Yin, Jiamin; Xue, Yi; Wang, Xin title: ML098 enhances intracellular bacterial clearance in bladder epithelial cells by activating Rab7 and promoting lysosomal biogenesis date: 2025 words: 4880 flesch: 56 summary: Effect on the expression of LAMP1 in HTB-9 cells The expression of lysosome associated membrane pro- tein 1 in E. coli group cells showed no significant difference compared to the control group (p>0.05, Figure 3). Effect on the expression of Rab7 and active Rab7 in HTB-9 cells To investigate the effect of ML098 on Rab7 and active Bangladesh J Pharmacol 2024; 19: 107-113 109 Rab7 expression in bladder epithelial cells, western blot and GST-pull down assay were conducted. keywords: bacteria; bladder; cells; coli group; e. coli; expression; group; infection; lysosomes; ml098; ml098 group; number; rab7 cache: bjp-77475.pdf plain text: bjp-77475.txt item: #867 of 942 id: bjp-7769 author: Yan, Hui; Jiang, Mingzhu; Wu, Qiongying; Gui, Zhongzheng title: Pharmacological mechanism of a drug pair of astragali and cinnamon in shiquan dabu decoction date: 2011 words: 3977 flesch: 59 summary: For Hb, it was enhanced, and had significant difference to group G (p<0.01), it can be inferred that the main action of drug pair astragali and cinnamon in shiquan dabu decoction was the improve- ment of the Hb content. However, the effect of this drug pair in shiquan dabu decoction is not known at present. keywords: astragali; blood; cinnamon; dabu; decoction; deficiency; drug; group; pair; shiquan cache: bjp-7769.pdf plain text: bjp-7769.txt item: #868 of 942 id: bjp-7771 author: Singhal, Manmohan; Paul, Arindam; Singh, Hemendra Pratap title: Design synthesis and biological evaluation of 2-methylphenyl semicarbazone derivatives date: 2011 words: 3531 flesch: 56 summary: Methoxy substitution in the aldehydic moiety of chalcone also favors antipyretic activity. Conclusion Most of the synthesized compounds were potential lead for antipyretic activity. keywords: activity; ch3; compounds; derivatives; synthesis cache: bjp-7771.pdf plain text: bjp-7771.txt item: #869 of 942 id: bjp-77820 author: Wang, Xiaofang; Tang, Chenquan; Jiang, Yi; Xue, Yi; Zhou, Enchao title: Total flavonoids of Abelmoschus manihot ameliorate lipid deposition in HK-2 cells by inhibiting fatty acid uptake mediated by CD36 date: 2024 words: 5360 flesch: 54 summary: Effects of total flavones on palmitic acid-induced lipid deposition in HK-2 cells Lipid deposition in renal tubular cells constitutes one of the crucial pathological mechanisms of chronic kidney disease. Effects of total flavones on palmitic acid-induced apoptosis of HK-2 cells Apoptosis of renal cells is one of the significant etiologies of kidney injury. keywords: acid; cd36; cells; china; deposition; disease; fatty; flavones; hk-2; kidney; lipid; manihot; palmitic; total cache: bjp-77820.pdf plain text: bjp-77820.txt item: #870 of 942 id: bjp-77912 author: Mohideen, Nishmaa Sulthan; Rao, Ankita; Begum , S. Mohamed Nainar Fazeela Mahaboob title: Anti-cancer potential of crude extracts from Dictyota bartayresiana in triple-negative breast cancer date: 2025 words: 5093 flesch: 54 summary: This variation is seen in cancer cells as they express hormone receptors, the human epithelial growth factor 2 onco- protein, and other biomarkers. Requirements Benchtop centrifuge; Breast cancer cell line (MDA-MB-231); Centrifuge tube (15 mL); DEDB extract (1 µg/mL); EEDB extract (1 µg/mL); High-glucose DMEM medium; Incubator; Micropipettes (100-1000 µL); PBS medium; T flask (25 mL); 6- Well culture plate Procedure Step 1: MDA-MB-231 cells were seeded in a six well plate at a density of 3 x 105 cells/well. keywords: acetate; acid; bartayresiana; breast; cancer; cell; compounds; dichloromethane; ethyl; extracts; study; test cache: bjp-77912.pdf plain text: bjp-77912.txt item: #871 of 942 id: bjp-78705 author: Patil, Ajit B.; Shinde, Anilkumar J. title: Cytotoxic, apoptotic, and anti-inflammatory properties of Adenoon indicum leaf methanolic extract using HT29 cell lines date: 2025 words: 3632 flesch: 54 summary: At a lower dose of 10 μg/mL and the highest dose of 160 μg/mL, the plant extract showed 29.2% and 96.4% inhibition of cancer cells. Previous research has focused on related chemicals, such as β-sitosterol and stigmasterol, which have similar but unique effects on cancer cells. keywords: activity; apoptosis; cancer; cells; extract; indicum; methanolic; potential cache: bjp-78705.pdf plain text: bjp-78705.txt item: #872 of 942 id: bjp-78798 author: Park, Hae-Ryong title: Cytotoxicity of paeonenoide C isolated from Paeonia obovata on HT-29 human colon cancer cells date: 2025 words: 4759 flesch: 52 summary: However, these drugs exhibit side effects on blood cells, epithelial cells, and the nervous system, highlighting the need to develop anti-cancer agents that can effectively inhibit cancer cells while minimizing adverse effects (Maroon et al., 2007). Therefore, if RB phosphorylation is inhibited, inhibitory effects on cell proliferation can be expected via cell cycle arrest, especially G1 arrest, in cancer cells (Jedinak and Sliva, 2008). keywords: assay; cancer; carbon; cells; colon; concentrations; effects; erk1/2; ht-29; ldh; paeonenoide; ppm cache: bjp-78798.pdf plain text: bjp-78798.txt item: #873 of 942 id: bjp-7902 author: Pornpunyapat, Jutarut; Chetpattananondh, Pakamas; Tongurai, Chakrit title: Mathematical modeling for extraction of essential oil from Aquilaria crassna by hydrodistillation and quality of agarwood oil date: 2011 words: 4388 flesch: 54 summary: In this work, agarwood oil was hydrodistilled at various temperatures in order to study the distillation kinetics and quality of the oil. 3 July 2011 DOI: 10.3329/bjp.v6i1.7902 Cite this article: Pornpunyapat J, Chetpattananondh P, Tongurai C. Mathematical modeling for extraction of essential oil from A uila ia crassna by hydrodistillation and quality of agarwood oil. keywords: agarwood; chemical; diffusion; distillation; extraction; hydrodistillation; model; oil cache: bjp-7902.pdf plain text: bjp-7902.txt item: #874 of 942 id: bjp-7907 author: Iftekhar, A. F. Md. Hassan; Choudhry, Zubaida Khatoon; Khan, Md. Ismail; Saleh, Ahmed Abu title: Comparative study of antibacterial activity of wood-decay fungi and antibiotics date: 2011 words: 2625 flesch: 51 summary: The response of microorganisms to mushroom extracts might vary depending upon the nature of environment in which it has been grown (Iwalokum et al., 2007). In this study not only the inhibitory effect but also sensitivity pattern of mushroom extract on two microorganisms S. aureus and E. coli was studied and compared with commonly used antibiotics cloxacillin, cephradine, azithromycin and ciprofloxacin. keywords: activity; extracts; inhibition; mushroom cache: bjp-7907.pdf plain text: bjp-7907.txt item: #875 of 942 id: bjp-7920 author: Sarkar, Sougat Sourendra title: Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials date: 2011 words: 4839 flesch: 48 summary: Three trials (6,216 patients) studied a diuretic (Carter, 1970; Hypertension study, 1974; PATS, 1995); the largest of these, PATS (5,665 patients), reported that indapamide reduced stroke recurrence by 29%. Perindopril 4 mg/ indapamide SR 1.5 mg Main outcomes Primary (composite) Major macro- or micro- vascular events Fatal or non-fatal stroke Fatal or nonfatal stroke Secondary and others All-cause mortality, cardio- vascular mortality, non- fatal MI, fatal- and non-fatal stroke, revascularization, heart failure admissions, new or worsening nephrop- athy All-cause mortality, cardio- vascular mortality, non-fatal MI, fatal- and non-fatal stroke, revascularization, heart failure admissions death from any cause, death from cardiovas- cular causes, death from cardiac causes, and death from stroke Recruitment period June 2001 to March 2003 May 1995 to November 1997 2001 to 2007 Mean follow-up duration 4.3 years 3.9 years 2.1 years and non-fatal stroke was seen (Odds ratio 0.7; 95% Confidence Interval 0.5 to 1.1). keywords: analysis; blood; combination; hypertension; indapamide; patients; perindopril; pressure; stroke; study; trials cache: bjp-7920.pdf plain text: bjp-7920.txt item: #876 of 942 id: bjp-79374 author: Hamza, Muhammad; Khalil-ur-Rehman, Muhammad; Yar, Muhammad title: Hypoglycemic potentials of Malvaviscus arboreus leaves against alloxanated albino rats date: 2025 words: 4205 flesch: 53 summary: M. arboreus leaves have antioxidant properties (Fahim et al., 2021), which may reduce oxidative stress and improve pancreatic function (Prabhakar and Doble, A Figure 1: Effects of M. arboreus leaf extracts on histopathological changes of pancreas in albino rats in diabetic control (A), drug control (B), n-hexane (C), dichloromethane (D), ethyl acetate (E), methanol (F) B C D E F Bangladesh J Pharmacol 2024; 19: 128-134 131 2011). The results highlighted the hypoglycemic potential of Malvaviscus arboreus leaf extracts in alloxan-induced albino rats. keywords: acetate; arboreus; blood; diabetic; dichloromethane; ethyl; extracts; glucose; leaves; rats cache: bjp-79374.pdf plain text: bjp-79374.txt item: #877 of 942 id: bjp-79648 author: Ikhou, Djamila; Boudou, Farouk; Ziani, Hanane; Kaid, M'hamed; Villemein, Didier title: Synthesis, characterization, and antibacterial activity of a novel hybrid material layered double hydroxide doped by diaminododecylphosphonic acid date: 2025 words: 7372 flesch: 43 summary: This underscores the versatility of LDHs in biomedical applications, particularly in drug delivery systems designed to improve treatment outcomes (Kim et al., 2014). The general formula for LDHs is given by: [ ²⁺₁₋ₓ ³⁺ₓ (OH)₂]ˣ⁺[Aⁿ⁻ˣ/ʸ·yH₂O]ˣ⁻ where M²⁺ and M³⁺ represent divalent and trivalent cations, respectively; Aⁿ⁻ is the intercalated anion; x is the charge density, defined as x = M³⁺/(M²⁺ + M³⁺); and y is the number of water molecules in the interlayer space (Chen et al., 2022). keywords: acid; activity; analysis; binding; dadpha; energy; et al; figure; hydroxide; interactions; ldh; ligand; material; potential; protein; so4; stability; target cache: bjp-79648.pdf plain text: bjp-79648.txt item: #878 of 942 id: bjp-79655 author: Yin, Hao; Xue, Yi; Wang, Xin title: 1α,25-Dihydroxyvitamin D3 reduces uropathogenic E. coli persistence in bladder epithelial cells by restoring lysosome acidification date: 2025 words: 4940 flesch: 54 summary: 1,25(OH)2D3 enhances lysosomal acidification in E. coli -infected HTB-9 cells Western blot analysis showed no significant difference in the expression level of lysosome-associated mem- 6000 4000 2000 0 C F U i n H T B -9 c e ll E. coli - + + - + + - + + 1,25-VD3 - - + - - + - - + 2500 2000 1500 1000 500 0 2000 1500 1000 500 0 ns a a A B C Figure 1: Effect of 1,25(OH)2D3 (1,25-VD3, 10 nM) on the intracellular persistent bacterial count of HTB-9 cells infected with E. coli. However, different from the other studies, this study focuses on the role of 1,25(OH)2D3 in enhan- cing the lysosomal acidification of HTB-9 cells and inhibiting the persistence of E. coli. keywords: 1,25(oh)2d3; acidification; atpase; bacteria; cells; coli; coli group; e. coli; et al; factor; group; transcription cache: bjp-79655.pdf plain text: bjp-79655.txt item: #879 of 942 id: bjp-80330 author: Falya, Yuniarti; Umar, Abd Kakhar; Suharyani, Ine; Anugra, Cindra Yulianto title: Diabetic wound healing activity of Myrmecodia pendens ethyl acetate fraction date: 2025 words: 6935 flesch: 54 summary: These findings suggest that M. pendens hydrogel may aid diabetic wound healing through molecular path- way modulation. This study explores the potential of ethyl acetate fraction-based hydrogel of M pendens for diabetic wound healing, both in silico and in vivo. keywords: acetate; acid; activity; compounds; concentration; day; diabetic; egfr; et al; ethyl; ethyl acetate; extract; fraction; group; healing; hydrogel; pendens; quercetin; wound; wound healing cache: bjp-80330.pdf plain text: bjp-80330.txt item: #880 of 942 id: bjp-80391 author: Tran, Trang Thu; Cuong, Nguyen Manh; Ha, Nguyen Xuan; Nakahama, Taisuke; Nguyen, Nam Trung title: Murrayafoline A inhibits inflammatory cytokines in RAW264.7 cells stimulated with LPS and poly (I:C) by targeting the aryl hydrocarbon receptor date: 2025 words: 2264 flesch: 52 summary: Murrayafoline A inhibits inflammatory cytokines in RAW264.7 cells stimulated with LPS and poly (I:C) by targeting the aryl hydrocarbon receptor Dear Editor, The anti-inflammatory activities of murrayafoline A, an alkaloid isolated from Glycosmis stenocarpa, remain poorly understood, particularly in cytokine regulation in macrophages. Interestingly, in the present study, murrayafoline A at concentrations of 3, 10, 30, and 60 μM increased Ahr expression by 2.4-, 2.5-, 5.5-, and 4.0-fold, respectively, compared with the control. keywords: ahr; cells; lps; murrayafoline; poly cache: bjp-80391.pdf plain text: bjp-80391.txt item: #881 of 942 id: bjp-80757 author: Desai, Akash; Yakub, Manure Md. Javeed Md.; Karade, Priti; Patil, Sudhir S. title: In vitro anti-cancer and antimicrobial activities of Abelmoschus esculentus root extracts date: 2025 words: 3177 flesch: 47 summary: Conclusion This study highlights the potential of A. esculentus Figure 1: Zone of inhibition of standard (500 µg/mL; clarithro- mycin) and extract (500 µg/mL) against H. pylori Table II Effects of carbopol against viscosity %Concentration pH Viscosity (cP) 1.0 6.80 585 1.5 6.45 1245 2.0 7.40 2375 Bangladesh J Pharmacol 2025; 20: 16-21 19 extract in treating oral squamous cell carcinoma. Phenolics provide oxidative protection and support immune function, while triterpenoids actively interfere with cancer cell signaling and survival. keywords: activity; cancer; cell; esculentus; extract; gel; inhibition; standard cache: bjp-80757.pdf plain text: bjp-80757.txt item: #882 of 942 id: bjp-80837 author: Mohideen, Nishmaa Sulthan; Ranganathan, Venkatalakshmi; Nainar, Fazeela Mahaboob Begum S. Mohamed title: Berberine chloride inhibits proliferation and angiogenesis in triple-negative breast cancer by down-regulating HIF-1α/VEGF/Ang pathway date: 2025 words: 3983 flesch: 44 summary: Mir Hassani Z, Nabiuni M, Parivar K, Abdirad S, Karimzadeh L. Melittin inhibits the expression of key genes involved in tumor microenvironment formation by suppressing HIF- 1alpha signaling in breast cancer cells. Conflict of Interest Authors declare no conflict of interest Acknowledgement Authors thank the Dean, SLS, BSACIST for the valuable support of the study References Afsar T, Trembley JH, Salomon CE, Razak S, Khan MR, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. keywords: angiogenesis; apoptosis; berberine; berberine chloride; breast; breast cancer; cancer; cells; chloride; expression; hif-1α; mda; vegf cache: bjp-80837.pdf plain text: bjp-80837.txt item: #883 of 942 id: bjp-80949 author: Erdogan, Ayse; Koras, Rahime Aybike title: Carvacrol enhances the sensitıvity of cetuximab in lung cancer cells through inducing apoptosis and cell cycle arrest date: 2025 words: 9304 flesch: 47 summary: The effects of cetuximab in combination with docetaxel for the acquired resistance to EGFR-TKI in non-small cell lung cancer cells. Abstract The intention of this work was to analyze that carvacrol could enhance cancer -inhibiting potency of cetuximab (monoclonal antibody) in lung cancer cells. keywords: a-549; a-549 cells; activity; apoptosis; cancer; carcinoma; carvacrol; cells; cetuximab; combination; control; cycle; cyclin; effects; egfr; et al; expression; growth; h1299; h1299 cells; human; ic10; ldh; lines; lung; pharmacol; treatment cache: bjp-80949.pdf plain text: bjp-80949.txt item: #884 of 942 id: bjp-80955 author: Zulfiqar, Abida; Bashir, Saima; Ahmed, Touqeer title: Protective effects of resveratrol in high fat diet– and metals (Al, Pb, As)-induced metabolic and cognitive impairments date: 2025 words: 7941 flesch: 54 summary: High fat diet is also reported to promote neuroinflammation, oxidative stress and decrease levels of brain-derived neurotrophic factor, all these factors as a result accelerate neurodegeneration (Morrison et al., 2010; Tan and Norhaizan, 2019). Abstract This study evaluated the neuroprotective role of resveratrol in rats co-exposed to high fat diet and metals (aluminum, lead, arsenic) for 60 days. keywords: bjp; c c; diet; effects; et al; exposure; fat; file:///c:/new%20manuscripts/80955; group; high; manuscript; meal; memory; metabolic; metals; resveratrol; sec; treatment cache: bjp-80955.pdf plain text: bjp-80955.txt item: #885 of 942 id: bjp-81017 author: Kurnianingsih, Nia; Puling, Imke Maria Del Rosario; Cahayani, Wike Astrid title: Efficacy of herbal medicines and standard antidepressants on neurotransmitter and behavioral outcomes in animal models of depression date: 2025 words: 6167 flesch: 41 summary: Notably, curcumin also exhibited the highest effectiveness in increasing serotonin levels among herbal studies. Quality assessment Two reviewers used the critical appraisal tool to independently determine whether each study has a low, moderate, or high risk of bias using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool for animal studies (Hooijmans et al., 2014). keywords: analysis; animals; antidepressant; curcumin; depression; effects; et al; herbal; interventions; medication; meta; placebo; studies; test; treatment cache: bjp-81017.pdf plain text: bjp-81017.txt item: #886 of 942 id: bjp-81249 author: Papri, Sarmin Sultana; Sonia, Sadia Binte Anwar title: Role of magnesium in major depressive disorder date: 2025 words: 8538 flesch: 60 summary: Studies with patients receiving magnesium treatment either alone or in combination with other strategies, such as non- pharmacological (physical exercise, psychotherapy) or antidepressants, and studies compared with placebo or pharmacotherapy alone, are considered for review. A case series showed a very interesting result: a rapid recovery (within 7 days) from depression symptoms in response to magnesium treatment in the form of glycinate and taurinate at a dose of 125-300 mg (Eby and Eby, 2006). keywords: d o; depression; disorder; et al; m g; magnesium; n d; o n; patients; review; studies; study; supplementation; symptoms; treatment cache: bjp-81249.pdf plain text: bjp-81249.txt item: #887 of 942 id: bjp-8133 author: Khan, Arif ullah; Khan, Qaiser Jabeen; Gilani, Anwar Hassan title: Pharmacological basis for the medicinal use of cardamom in asthma date: 2011 words: 2420 flesch: 51 summary: Crude extract of cardamom which tested positive for alkaloids, flavonoids, saponins, sterols and tannins, when tested against carbachol-mediated bronchoconstriction in rats under anesthesia, dose-dependently (10-100 mg/kg) suppressed the carbachol (1 µmol/kg)-evoked increase in the inspiratory pressure. In isolated rabbit trachea tissues, crude extract of cardamom caused relaxation of both carbachol (1 µM) and high K+ (80 mM)-induced contractions, like that caused by verapamil, suggesting its Ca++ channel blockade action. keywords: asthma; ca++; carbachol; cardamom; effect; extract; gilani; khan; use cache: bjp-8133.pdf plain text: bjp-8133.txt item: #888 of 942 id: bjp-8154 author: Firoz, Momin; Bharatesh, Kalai; Nilesh, Patole; Vijay, Godse; Tabassum, Shikalgar; Nilofar, Naikwade title: Cardioprotective activity of ethanolic extract of Callistemon lanceolatus leaves on doxorubicin-induced cardiomyopathy in rats date: 2011 words: 4858 flesch: 53 summary: The ethanolic extract of C. lanceolatus showed strong elastase inhibition and DPPH radical scavenging activi- ties (Kim et al., 2009). The Lambadi tribals of north telangana districts of Andhra Pradesh use this plant for the treatment of pain, gastrointestinal disorders and infectious diseases (Sudhakar et al., 2004). keywords: control; doxorubicin; extract; group; heart; lanceolatus; leaves; p<0.01; pressure; rats; weight cache: bjp-8154.pdf plain text: bjp-8154.txt item: #889 of 942 id: bjp-81605 author: Yogananthan, Dhanapal; Venkatachalam, Ashok Raj Kattur; Muthiah, Ramanathan title: Novel CRT2 peptide inhibits tumor growth and angiogenesis in colorectal cancer HT-116 cell lines via PI3K/ERK signaling pathway date: 2025 words: 7201 flesch: 54 summary: This experimental protocol is carried out on CRT2 cells treated at IC50 concentrations, as well as PBS -treated cells, as the control group. The peptide inhibits cell development in HT-116 cancer cells by blocking the cell cycle transition from G1 to S, as observed G1/S phase arrest with CRT2 treatment. keywords: anti; apoptosis; bangladesh; binding; cancer; cell; colorectal; control; crt2; crt2 peptide; cycle; figure; fitc; ht-116; lines; peptide; pi3k; protein; vegfr1 cache: bjp-81605.pdf plain text: bjp-81605.txt item: #890 of 942 id: bjp-81752 author: Arshad, Hanzla; Saleem, Mohammad title: Cytotoxic effect of Luffa cylindrica leaf extract on MCF-7 cell lines date: 2025 words: 7426 flesch: 53 summary: Cell lines All cell lines were sourced from the Center of Excellen- ce in Molecular Biology, University of the Punjab. Three wells per cell line were treated with L. cylindrica extract at their respective IC₅₀ concentrations, while the other three served as untreated controls. keywords: acid; assay; cancer; cells; cylindrica; et al; extract; hours; lines; mcf-7; min; ros; scratch cache: bjp-81752.pdf plain text: bjp-81752.txt item: #891 of 942 id: bjp-821 author: Kumar, Ramanathan Sambath; Sundram, R Shanmuga; Sivakumar, P.; Nethaji, R.; Senthil, V.; Murthy, N. Venkateswara; Kanagasabi, R. title: CNS activity of the methanol extracts of Careya arborea in experimental animal model date: 2008 words: 4820 flesch: 57 summary: Table I Effect of methanol extract of Careya arborea on general behavioral profiles in mice Behavior type Diazepam Propylene glycol Extract (mg/kg) 50 100 200 (5 mg/kg) (5 mL/kg) Spontaneous activity + + + + + + + + + + – Alertness + + + + + + + + + – Awareness + + + + + + + + + – Sound response + + + + + + + + + + + – Touch response + + + + + + + + + + + + + – Pain response + + + + + + + + + + + – Righting reflex + + + + + + + + + + – Pinna reflex + + + + + + + + + + + + – Grip strength + + + + + + + + + + + + – –, no effect; +, slight depression; ++, moderate depression; +++, strong depression; ++++, very strong depression; n = 8 Bangladesh J Pharmacol 2008; 3: 36-43 39 Effect on muscle relaxant activity In the traction test, the mice treated with methanol extract of C. arborea showed a significant failure in traction at all doses tested. Previous report from our laboratory showed hepatoprotective and anti-oxidant activity (Sambath Kumar et al., 2005a), antimicrobial and in vitro anti-oxidant activity (Sambath Kumar et al., 2006), anti-inflammatory and analgesic activity (Sam- bath Kumar et al., 2005b), anti-tumor and anti-oxidant activities of methanol extract of C. arborea (Sambath Kumar et al., 2008a) and N-nitrosodiethylamine-indu- ced hepatocarcinogenesis (Sambath Kumar, 2008b). keywords: + +; activity; arborea; extract; methanol; methanol extract; mice; test cache: bjp-821.pdf plain text: bjp-821.txt item: #892 of 942 id: bjp-822 author: Chowdhury, Md. Anup Rahman; Hossain, A. K. M. Mosharrof; Dey, Sudhangshu Ranjan; Akhtaruzzaman, A. K. M.; Islam, Nur-A-Farhana title: A comparative study on the effect of streptokinase between diabetic and non-diabetic myocardial infarction patients date: 2008 words: 3943 flesch: 47 summary: So, due attention is required for the better management of diabetic myocardial infarction patients. By using the same resolution criteria, in our study we observed the similar results in non-diabetic myocardial infarction where 48.4% patients showed complete resolution, 31.7% patient’s partial resolution and 19.8% showed failed Table II Comparison of ST resolution between non-diabetic and diabetic patients Group Number of patients showing ST resolution at 90 min after streptokinase Total Chi value p value Complete Partial Failed Non-diabetic 61 40 25 126 40.7 <0.001 keywords: acute; diabetes; diabetic; elevation; infarction; non; patients; resolution; segment; streptokinase cache: bjp-822.pdf plain text: bjp-822.txt item: #893 of 942 id: bjp-823 author: Ahmed, Selim; Hossain, A. K. M. Mosharrof; Dey, Sudhangshu R.; Akhtaruzzaman, A. K. M.; Siddika, Mushammath Morium title: A comparative study on the effects of niacin plus atorvastatin with that of fenofibrate plus atorvastatin in dyslipidemia date: 2008 words: 5940 flesch: 56 summary: ; ‘-’ sign indicates reduction of lipid level in percentage; ‘+’ sign indicates increase of lipid level in percentage; Data are mean ± SD Bangladesh J Pharmacol 2008; 3: 8-16 11 niacin-atorvastatin combination therapy (Z=2.05, p<0.05). Total cholesterol level was reduced from 213.5 ± 28.5 mg/dL to 158.6 ± 19.5 mg/dL and this change was statistically significant (t=14.706, p<0.001, 95% CI 47.350 to 62.535). keywords: atorvastatin; combination; fenofibrate; group; hdl; ldl; level; niacin; patients; study; treatment cache: bjp-823.pdf plain text: bjp-823.txt item: #894 of 942 id: bjp-824 author: Chowdhury, Muhammad Mustafizur Rahman; Moinuddin, Shah Md.; Islam, Md. Kamrul title: Effects of turmeric and garlic on blood cholesterol level date: 2008 words: 1866 flesch: 55 summary: Bangladesh Journal of Pharmacology Research Article Effects of turmeric and garlic on Effects of turmeric and garlic on Effects of turmeric and garlic on blood cholesterol level in guinea pigblood cholesterol level in guinea pigblood cholesterol level in guinea pig BJP Introduction The problem of atherosclerosis, thrombosis and myo- cardial infarction has recently increased many folds in urban population of Bangladesh (Zaman et al., 1981). Abstract This study has been attempted to investigate the effects of garlic and turmeric on blood cholesterol level. keywords: animals; cholesterol; day; garlic; level; turmeric cache: bjp-824.pdf plain text: bjp-824.txt item: #895 of 942 id: bjp-82674 author: Ramalingam, Sivakumar; Renuka, Saravanan title: Anti-tumor activity of Simarouba glauca on Ehrlich ascites carcinoma in mice date: 2025 words: 7037 flesch: 50 summary: A droplet of the diluted suspension was placed on a clean hemocytometer, and tumor cells were counted under a light microscope in 64 small squares of the counting chamber. In parallel, there was a significant decrease in total serum protein in the Ehrlich ascites carcinoma control (3.3 ± 0.1 g/dL), suggesting impaired protein synthesis, possibly due to hepatic dysfunction or increased catabolism by tumor cells. keywords: antioxidant; ascites; cancer; carcinoma; cells; ehrlich; ehrlich ascites; extract; glauca; group; mice; survival; tumor cache: bjp-82674.pdf plain text: bjp-82674.txt item: #896 of 942 id: bjp-828 author: Hoque, Md. Mahbubul; Islam, Md. Rabiul title: Cytotoxicity study of some indophenines and isatin derivatives date: 2008 words: 3168 flesch: 66 summary: Again, indophenines 5a and 5b were prepared by the reaction between isatin and thiazol in the molar ratio of 2:1 in A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2008; 3: 21-26 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index; ISSN: 1991-0088 Bangladesh J Pharmacol. keywords: c c; cm-1 cache: bjp-828.pdf plain text: bjp-828.txt item: #897 of 942 id: bjp-83064 author: Lv, Daoyuan; Su, Yuqing; Li, Jun; Zhu, Huixian; Tang, Qiong; Yu, Yafen title: Ginkgolide B alleviates renal and podocyte injury in membranous nephropathy by inhibiting ferroptosis date: 2025 words: 4731 flesch: 38 summary: Original magnification: ×400 (CD2AP), ×630 (Masson, PASM, and WT-1) 126 Bangladesh J Pharmacol 2025; 20: 122-130 A B C D E F G NC GB PHN + GB PHN P ru s s ia n b lu e N C O A 4 A C S L 4 L P C A T 3 a b a b b b b b b b b b Figure 3: Effects of ginkgolide B on renal ferroptosis in rats with passive Heymann nephritis. In diabe- tic kidney disease, hyperglycemia and advanced glyca- tion end products induce podocyte ferroptosis through inhibition of Nrf2 (Gao et al., 2025), suppression of AMPK (J. Zhang et al., 2025), or dysregulation of the p53/GPX4 axis (Pei et al., 2025), which contrasts with the immune complex–driven pathological changes in membranous nephropathy. keywords: b b; ferroptosis; ginkgolide; injury; kidney; levels; nephritis; nephropathy; podocyte; rats; renal; zhang cache: bjp-83064.pdf plain text: bjp-83064.txt item: #898 of 942 id: bjp-83249 author: Gaikwad, Ravindra; Shinde, Anilkumar; Nadaf, Sameer title: Antiproliferative activity of Tribulus terrestris stem bark extract against A431 cells date: 2025 words: 1502 flesch: 51 summary: The moderate cytotoxicity of T. terrestris extract showed increased interest in plant-based treatments. As shown in Figure 1, the stem bark methanolic extract of T. terrestris inhibited the viability of 35.26 ± 0.95% A431 cells, corroborating the cytotoxic effect following a 24-hours treatment at the tested dose. keywords: cells; extract; terrestris; tribulus cache: bjp-83249.pdf plain text: bjp-83249.txt item: #899 of 942 id: bjp-833 author: Paramasivam, M.; Aktar, Md. Wasim; Poi, R.; Banerjee, H.; Bandyopadhyay, A. title: Occurrence of curcuminoids in Curcuma longa: A quality standardization by HPTLC date: 2008 words: 1650 flesch: 50 summary: Curcumin, demethoxycurcumin and bis-demetho- xycurcumin, three major pharmacologically important curcuminoids, have been isolated from C. longa (Gupta et al., 1999) and has been shown to possess anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-mutagenic, anti-fungal, anti-viral and anti-cancer activity (Chatto- padhyay et al., 2004; Conclusion The HPTLC method for the simultaneous analysis of curcumin, demethoxycurcumin and bis-demethoxy- curcumin from C. longa reported here is very simple, sensitive, economic and suitable for rapid screening of large number of plant samples. keywords: bis; curcuma; curcuminoids; demethoxycurcumin; hptlc; longa cache: bjp-833.pdf plain text: bjp-833.txt item: #900 of 942 id: bjp-834 author: Khan, Rahat; Uddin, Md. Imam; Alam, Md. Sultan; Hossain, Mohammad Mamun; Islam, Md. Rabiul title: Synthesis and preliminary evaluation of brominated 5-methyl-2,4-dihydropyrazol-3-one and its derivatives as cytotoxic agents date: 2008 words: 4738 flesch: 67 summary: The results of the chemical tests are given bellow (Table II): The resulting spectroscopic datas are given bellow: Compound 1a: IR (Nujol): 3480 (νN-H); 2980, 2880 (νC-H aliphatic); 2700 (νO-H enolic); 1680 (νC=O lactam); 1615 (νC=N); 1580 (νC=C aromatic); 1515 (δN-H) cm-1; 1H-NMR (DMSO-d6): δ 5.2 (s, 1H, =CH); 2.1 (s, 3H, CH3); 10.0 (s, 1H, NH); 10.5 (s, 1H, OH); 13C-NMR (DMSO-d6): δ 11.4 (CH3), 89.23 (C-4); 139.82 (C-3); 161.42 (=C-OH); MS: m/ z (% of rel. Bangladesh J Pharmacol 2008; 3: 27-35 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index; ISSN: keywords: aromatic; compounds; derivatives; nmr; no2 cache: bjp-834.pdf plain text: bjp-834.txt item: #901 of 942 id: bjp-83467 author: Tran, Thanh Trung; Vu, Thi Tien; Tran, Kien Trung; Nakahama, Taisuke; Nguyen, Nam Trung title: 6-Formylindolo[3,2-b]carbazole promotes proliferation of adipose-derived mesenchymal stem cells via activation of the Ahr–IL-6 signaling axis date: 2025 words: 2226 flesch: 53 summary: Flow cytometry (MACSQuant® VYB, Mil- tenyi Biotec, Germany) analysis further confirmed that AD-MSCs retained their characteristic surface marker expression following FICZ treatment, including high levels of CD90, CD73, and CD105, and a lack of HLA- DR expression (Table I), indicating preserved immuno- phenotypic identity. These findings indicate that FICZ treatment does not alter the characteristic surface marker expression of AD -MSCs. keywords: ahr; cells; ficz; mscs cache: bjp-83467.pdf plain text: bjp-83467.txt item: #902 of 942 id: bjp-835 author: Alam, Md. Ashraful; Uddin, Riaz; Haque, Shamsul title: Protein binding interaction of warfarin and acetaminophen in presence of arsenic and of the biological system date: 2008 words: 3776 flesch: 49 summary: Free warfarin concentration increased due to addition of acetaminophen (paracetamol) which reduced the binding of warfarin to BSA. Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle. keywords: acetaminophen; arsenic; bangladesh; binding; concentration; drug; presence; protein; site; warfarin cache: bjp-835.pdf plain text: bjp-835.txt item: #903 of 942 id: bjp-836 author: Mosaddek, Abu Syed Md.; Rashid, Md. Mamun Ur title: A comparative study of the anti-inflammatory effect of aqueous extract of neem leaf and dexamethasone date: 2008 words: 2065 flesch: 57 summary: The present study suggests that anti-inflammatory effect of neem extract is less than that produced by dexamethasone. Neem leaf extract exerted significant anti-inflammatory effect in cotton pallet granuloma in rats (Chattopadhyay, 1998). keywords: dexamethasone; effect; extract; formalin; leaf; neem cache: bjp-836.pdf plain text: bjp-836.txt item: #904 of 942 id: bjp-837 author: Saha, Shusmita; Ashrafuzzaman, Syed title: Impact of prophylactic use of antimicrobials in abdominal surgery in two tertiary level hospitals date: 2008 words: 1767 flesch: 52 summary: 7KLV�ZRUN�LV�OLFHQVHG�XQGHU�D�&UHDWLYH�&RPPRQV�$WWULEXWLRQ�����/LFHQVH��