id	sid	tid	token	lemma	pos
bjp-13842	1	1	bangladesh	bangladesh	PROPN
bjp-13842	1	2	journal	journal	PROPN
bjp-13842	1	3	of	of	ADP
bjp-13842	1	4	pharmacology	pharmacology	NOUN
bjp-13842	1	5	research	research	NOUN
bjp-13842	1	6	article	article	NOUN
bjp-13842	1	7	trichostatin	trichostatin	VERB
bjp-13842	1	8	a	a	DET
bjp-13842	1	9	destabilizes	destabilize	NOUN
bjp-13842	1	10	hif-2α	hif-2α	NOUN
bjp-13842	1	11	through	through	ADP
bjp-13842	1	12	a	a	DET
bjp-13842	1	13	vhl	vhl	NOUN
bjp-13842	1	14	-	-	PUNCT
bjp-13842	1	15	independent	independent	ADJ
bjp-13842	1	16	but	but	CCONJ
bjp-13842	1	17	proteasome	proteasome	NOUN
bjp-13842	1	18	-	-	PUNCT
bjp-13842	1	19	dependent	dependent	ADJ
bjp-13842	1	20	pathway	pathway	NOUN
bjp-13842	1	21	in	in	ADP
bjp-13842	1	22	cancer	cancer	NOUN
bjp-13842	1	23	cell	cell	NOUN
bjp-13842	1	24	lines	line	NOUN
bjp-13842	1	25	and	and	CCONJ
bjp-13842	1	26	tumor	tumor	NOUN
bjp-13842	1	27	xenografts	xenografts	PROPN
bjp-13842	1	28	bjp	bjp	PROPN
bjp-13842	1	29	introduction	introduction	NOUN
bjp-13842	1	30	the	the	DET
bjp-13842	1	31	survival	survival	NOUN
bjp-13842	1	32	of	of	ADP
bjp-13842	1	33	mammalian	mammalian	ADJ
bjp-13842	1	34	cells	cell	NOUN
bjp-13842	1	35	requires	require	VERB
bjp-13842	1	36	constant	constant	ADJ
bjp-13842	1	37	oxygen	oxygen	NOUN
bjp-13842	1	38	and	and	CCONJ
bjp-13842	1	39	nutrients	nutrient	NOUN
bjp-13842	1	40	.	.	PUNCT
bjp-13842	2	1	precise	precise	ADJ
bjp-13842	2	2	homeostatic	homeostatic	ADJ
bjp-13842	2	3	control	control	NOUN
bjp-13842	2	4	has	have	AUX
bjp-13842	2	5	been	be	AUX
bjp-13842	2	6	developed	develop	VERB
bjp-13842	2	7	to	to	PART
bjp-13842	2	8	continuously	continuously	ADV
bjp-13842	2	9	adjust	adjust	VERB
bjp-13842	2	10	blood	blood	NOUN
bjp-13842	2	11	flow	flow	NOUN
bjp-13842	2	12	,	,	PUNCT
bjp-13842	2	13	which	which	PRON
bjp-13842	2	14	may	may	AUX
bjp-13842	2	15	maintain	maintain	VERB
bjp-13842	2	16	adequate	adequate	ADJ
bjp-13842	2	17	oxygen	oxygen	NOUN
bjp-13842	2	18	tension	tension	NOUN
bjp-13842	2	19	,	,	PUNCT
bjp-13842	2	20	ph	ph	NOUN
bjp-13842	2	21	,	,	PUNCT
bjp-13842	2	22	and	and	CCONJ
bjp-13842	2	23	appropriate	appropriate	ADJ
bjp-13842	2	24	supply	supply	NOUN
bjp-13842	2	25	of	of	ADP
bjp-13842	2	26	glucose	glucose	NOUN
bjp-13842	2	27	and	and	CCONJ
bjp-13842	2	28	other	other	ADJ
bjp-13842	2	29	nutrients	nutrient	NOUN
bjp-13842	2	30	(	(	PUNCT
bjp-13842	2	31	carmeliet	carmeliet	NOUN
bjp-13842	2	32	,	,	PUNCT
bjp-13842	2	33	2000	2000	NUM
bjp-13842	2	34	)	)	PUNCT
bjp-13842	2	35	.	.	PUNCT
bjp-13842	3	1	however	however	ADV
bjp-13842	3	2	,	,	PUNCT
bjp-13842	3	3	in	in	ADP
bjp-13842	3	4	solid	solid	ADJ
bjp-13842	3	5	tumors	tumor	NOUN
bjp-13842	3	6	,	,	PUNCT
bjp-13842	3	7	the	the	DET
bjp-13842	3	8	tumor	tumor	NOUN
bjp-13842	3	9	expansion	expansion	NOUN
bjp-13842	3	10	exceeds	exceed	VERB
bjp-13842	3	11	the	the	DET
bjp-13842	3	12	development	development	NOUN
bjp-13842	3	13	of	of	ADP
bjp-13842	3	14	blood	blood	NOUN
bjp-13842	3	15	vessels	vessel	NOUN
bjp-13842	3	16	,	,	PUNCT
bjp-13842	3	17	which	which	PRON
bjp-13842	3	18	results	result	VERB
bjp-13842	3	19	in	in	ADP
bjp-13842	3	20	a	a	DET
bjp-13842	3	21	hypoxic	hypoxic	ADJ
bjp-13842	3	22	microenvironment	microenvironment	NOUN
bjp-13842	3	23	(	(	PUNCT
bjp-13842	3	24	evans	evans	PROPN
bjp-13842	3	25	and	and	CCONJ
bjp-13842	3	26	koch	koch	PROPN
bjp-13842	3	27	,	,	PUNCT
bjp-13842	3	28	2003	2003	NUM
bjp-13842	3	29	;	;	PUNCT
bjp-13842	3	30	hockel	hockel	NOUN
bjp-13842	3	31	and	and	CCONJ
bjp-13842	3	32	vaupel	vaupel	NOUN
bjp-13842	3	33	,	,	PUNCT
bjp-13842	3	34	2001	2001	NUM
bjp-13842	3	35	)	)	PUNCT
bjp-13842	3	36	.	.	PUNCT
bjp-13842	4	1	hypoxia	hypoxia	NOUN
bjp-13842	4	2	is	be	AUX
bjp-13842	4	3	not	not	PART
bjp-13842	4	4	only	only	ADV
bjp-13842	4	5	a	a	DET
bjp-13842	4	6	result	result	NOUN
bjp-13842	4	7	of	of	ADP
bjp-13842	4	8	decrease	decrease	NOUN
bjp-13842	4	9	in	in	ADP
bjp-13842	4	10	blood	blood	NOUN
bjp-13842	4	11	vessels	vessel	NOUN
bjp-13842	4	12	,	,	PUNCT
bjp-13842	4	13	but	but	CCONJ
bjp-13842	4	14	also	also	ADV
bjp-13842	4	15	a	a	DET
bjp-13842	4	16	consequence	consequence	NOUN
bjp-13842	4	17	of	of	ADP
bjp-13842	4	18	the	the	DET
bjp-13842	4	19	development	development	NOUN
bjp-13842	4	20	of	of	ADP
bjp-13842	4	21	anatomically	anatomically	ADV
bjp-13842	4	22	and	and	CCONJ
bjp-13842	4	23	functionally	functionally	ADV
bjp-13842	4	24	abnormal	abnormal	ADJ
bjp-13842	4	25	vasculatures	vasculature	NOUN
bjp-13842	4	26	(	(	PUNCT
bjp-13842	4	27	vaupel	vaupel	NOUN
bjp-13842	4	28	,	,	PUNCT
bjp-13842	4	29	2004	2004	NUM
bjp-13842	4	30	)	)	PUNCT
bjp-13842	4	31	.	.	PUNCT
bjp-13842	5	1	blood	blood	NOUN
bjp-13842	5	2	vessels	vessel	NOUN
bjp-13842	5	3	in	in	ADP
bjp-13842	5	4	tumors	tumor	NOUN
bjp-13842	5	5	poorly	poorly	ADV
bjp-13842	5	6	develop	develop	VERB
bjp-13842	5	7	,	,	PUNCT
bjp-13842	5	8	which	which	PRON
bjp-13842	5	9	are	be	AUX
bjp-13842	5	10	tortuous	tortuous	ADJ
bjp-13842	5	11	and	and	CCONJ
bjp-13842	5	12	leaky	leaky	ADJ
bjp-13842	5	13	,	,	PUNCT
bjp-13842	5	14	and	and	CCONJ
bjp-13842	5	15	frequently	frequently	ADV
bjp-13842	5	16	contain	contain	VERB
bjp-13842	5	17	dead	dead	ADJ
bjp-13842	5	18	ends	end	NOUN
bjp-13842	5	19	due	due	ADP
bjp-13842	5	20	to	to	ADP
bjp-13842	5	21	the	the	DET
bjp-13842	5	22	dysregulation	dysregulation	NOUN
bjp-13842	5	23	of	of	ADP
bjp-13842	5	24	angiogenesis	angiogenesis	NOUN
bjp-13842	5	25	in	in	ADP
bjp-13842	5	26	tumors	tumor	NOUN
bjp-13842	5	27	(	(	PUNCT
bjp-13842	5	28	fraisi	fraisi	PROPN
bjp-13842	5	29	et	et	PROPN
bjp-13842	5	30	al	al	PROPN
bjp-13842	5	31	.	.	PROPN
bjp-13842	5	32	,	,	PUNCT
bjp-13842	5	33	2009	2009	NUM
bjp-13842	5	34	)	)	PUNCT
bjp-13842	5	35	.	.	PUNCT
bjp-13842	6	1	the	the	DET
bjp-13842	6	2	activation	activation	NOUN
bjp-13842	6	3	of	of	ADP
bjp-13842	6	4	hypoxia	hypoxia	NOUN
bjp-13842	6	5	-	-	PUNCT
bjp-13842	6	6	inducible	inducible	ADJ
bjp-13842	6	7	factor-1	factor-1	PROPN
bjp-13842	6	8	(	(	PUNCT
bjp-13842	6	9	hif-1	hif-1	NUM
bjp-13842	6	10	)	)	PUNCT
bjp-13842	6	11	,	,	PUNCT
bjp-13842	6	12	a	a	DET
bjp-13842	6	13	transcription	transcription	NOUN
bjp-13842	6	14	factor	factor	NOUN
bjp-13842	6	15	,	,	PUNCT
bjp-13842	6	16	is	be	AUX
bjp-13842	6	17	one	one	NUM
bjp-13842	6	18	of	of	ADP
bjp-13842	6	19	the	the	DET
bjp-13842	6	20	most	most	ADV
bjp-13842	6	21	important	important	ADJ
bjp-13842	6	22	responses	response	NOUN
bjp-13842	6	23	of	of	ADP
bjp-13842	6	24	tumors	tumor	NOUN
bjp-13842	6	25	to	to	PART
bjp-13842	6	26	hypoxia	hypoxia	VERB
bjp-13842	6	27	for	for	ADP
bjp-13842	6	28	survival	survival	NOUN
bjp-13842	6	29	.	.	PUNCT
bjp-13842	7	1	it	it	PRON
bjp-13842	7	2	has	have	AUX
bjp-13842	7	3	been	be	AUX
bjp-13842	7	4	widely	widely	ADV
bjp-13842	7	5	accepted	accept	VERB
bjp-13842	7	6	that	that	SCONJ
bjp-13842	7	7	hif-1	hif-1	NUM
bjp-13842	7	8	functions	function	NOUN
bjp-13842	7	9	as	as	ADP
bjp-13842	7	10	a	a	DET
bjp-13842	7	11	master	master	NOUN
bjp-13842	7	12	regulator	regulator	NOUN
bjp-13842	7	13	in	in	ADP
bjp-13842	7	14	the	the	DET
bjp-13842	7	15	molecular	molecular	ADJ
bjp-13842	7	16	and	and	CCONJ
bjp-13842	7	17	responses	response	NOUN
bjp-13842	7	18	to	to	ADP
bjp-13842	7	19	hypoxia	hypoxia	NOUN
bjp-13842	7	20	(	(	PUNCT
bjp-13842	7	21	semenza	semenza	NOUN
bjp-13842	7	22	,	,	PUNCT
bjp-13842	7	23	2009	2009	NUM
bjp-13842	7	24	;	;	PUNCT
bjp-13842	7	25	caro	caro	NOUN
bjp-13842	7	26	,	,	PUNCT
bjp-13842	7	27	2001	2001	NUM
bjp-13842	7	28	)	)	PUNCT
bjp-13842	7	29	.	.	PUNCT
bjp-13842	8	1	hif-1	hif-1	PUNCT
bjp-13842	8	2	is	be	AUX
bjp-13842	8	3	a	a	DET
bjp-13842	8	4	heterodimer	heterodimer	NOUN
bjp-13842	8	5	complex	complex	NOUN
bjp-13842	8	6	and	and	CCONJ
bjp-13842	8	7	consists	consist	VERB
bjp-13842	8	8	of	of	ADP
bjp-13842	8	9	a	a	DET
bjp-13842	8	10	constitutively	constitutively	ADV
bjp-13842	8	11	expressed	express	VERB
bjp-13842	8	12	subunit	subunit	NOUN
bjp-13842	8	13	(	(	PUNCT
bjp-13842	8	14	arnt	arnt	ADJ
bjp-13842	8	15	)	)	PUNCT
bjp-13842	8	16	and	and	CCONJ
bjp-13842	8	17	a	a	DET
bjp-13842	8	18	subunit	subunit	NOUN
bjp-13842	8	19	,	,	PUNCT
bjp-13842	8	20	of	of	ADP
bjp-13842	8	21	which	which	PRON
bjp-13842	8	22	the	the	DET
bjp-13842	8	23	expression	expression	NOUN
bjp-13842	8	24	is	be	AUX
bjp-13842	8	25	regulated	regulate	VERB
bjp-13842	8	26	by	by	ADP
bjp-13842	8	27	oxygen	oxygen	NOUN
bjp-13842	8	28	levels	level	NOUN
bjp-13842	8	29	.	.	PUNCT
bjp-13842	9	1	when	when	SCONJ
bjp-13842	9	2	oxygen	oxygen	NOUN
bjp-13842	9	3	is	be	AUX
bjp-13842	9	4	sufficient	sufficient	ADJ
bjp-13842	9	5	,	,	PUNCT
bjp-13842	9	6	hif	hif	PROPN
bjp-13842	9	7	-	-	PUNCT
bjp-13842	9	8	α	α	PROPN
bjp-13842	9	9	is	be	AUX
bjp-13842	9	10	hydroxylated	hydroxylate	VERB
bjp-13842	9	11	at	at	ADP
bjp-13842	9	12	two	two	NUM
bjp-13842	9	13	prolyl	prolyl	ADJ
bjp-13842	9	14	residues	residue	NOUN
bjp-13842	9	15	in	in	ADP
bjp-13842	9	16	the	the	DET
bjp-13842	9	17	oxygen	oxygen	NOUN
bjp-13842	9	18	-	-	PUNCT
bjp-13842	9	19	dependent	dependent	ADJ
bjp-13842	9	20	degradation	degradation	NOUN
bjp-13842	9	21	domain	domain	NOUN
bjp-13842	9	22	(	(	PUNCT
bjp-13842	9	23	odd	odd	ADJ
bjp-13842	9	24	)	)	PUNCT
bjp-13842	9	25	by	by	ADP
bjp-13842	9	26	prolyl	prolyl	PROPN
bjp-13842	9	27	hydroxylases	hydroxylase	NOUN
bjp-13842	9	28	(	(	PUNCT
bjp-13842	9	29	phd	phd	NOUN
bjp-13842	9	30	)	)	PUNCT
bjp-13842	9	31	,	,	PUNCT
bjp-13842	9	32	which	which	PRON
bjp-13842	9	33	allows	allow	VERB
bjp-13842	9	34	the	the	DET
bjp-13842	9	35	binding	binding	NOUN
bjp-13842	9	36	of	of	ADP
bjp-13842	9	37	vhl	vhl	PROPN
bjp-13842	9	38	,	,	PUNCT
bjp-13842	9	39	an	an	DET
bjp-13842	9	40	e3	e3	NOUN
bjp-13842	9	41	ubiquitin	ubiquitin	NOUN
bjp-13842	9	42	ligase	ligase	NOUN
bjp-13842	9	43	.	.	PUNCT
bjp-13842	10	1	under	under	ADP
bjp-13842	10	2	this	this	DET
bjp-13842	10	3	condition	condition	NOUN
bjp-13842	10	4	,	,	PUNCT
bjp-13842	10	5	hif	hif	PROPN
bjp-13842	10	6	-	-	PUNCT
bjp-13842	10	7	α	α	PROPN
bjp-13842	10	8	is	be	AUX
bjp-13842	10	9	ubiquitinated	ubiquitinated	ADJ
bjp-13842	10	10	and	and	CCONJ
bjp-13842	10	11	targeted	target	VERB
bjp-13842	10	12	for	for	ADP
bjp-13842	10	13	subsequent	subsequent	ADJ
bjp-13842	10	14	proteasome	proteasome	NOUN
bjp-13842	10	15	degradation	degradation	NOUN
bjp-13842	10	16	(	(	PUNCT
bjp-13842	10	17	semenza	semenza	NOUN
bjp-13842	10	18	,	,	PUNCT
bjp-13842	10	19	2000	2000	NUM
bjp-13842	10	20	)	)	PUNCT
bjp-13842	10	21	.	.	PUNCT
bjp-13842	11	1	in	in	ADP
bjp-13842	11	2	addition	addition	NOUN
bjp-13842	11	3	to	to	ADP
bjp-13842	11	4	hypoxia	hypoxia	NOUN
bjp-13842	11	5	,	,	PUNCT
bjp-13842	11	6	hif	hif	PROPN
bjp-13842	11	7	-	-	PUNCT
bjp-13842	11	8	α	α	NOUN
bjp-13842	11	9	expression	expression	NOUN
bjp-13842	11	10	has	have	AUX
bjp-13842	11	11	been	be	AUX
bjp-13842	11	12	shown	show	VERB
bjp-13842	11	13	to	to	PART
bjp-13842	11	14	be	be	AUX
bjp-13842	11	15	regulated	regulate	VERB
bjp-13842	11	16	by	by	ADP
bjp-13842	11	17	various	various	ADJ
bjp-13842	11	18	growth	growth	NOUN
bjp-13842	11	19	factors	factor	NOUN
bjp-13842	11	20	,	,	PUNCT
bjp-13842	11	21	hormones	hormone	NOUN
bjp-13842	11	22	,	,	PUNCT
bjp-13842	11	23	oncogenes	oncogene	NOUN
bjp-13842	11	24	and	and	CCONJ
bjp-13842	11	25	tumor	tumor	NOUN
bjp-13842	11	26	suppressors	suppressor	NOUN
bjp-13842	11	27	(	(	PUNCT
bjp-13842	11	28	semenza	semenza	PROPN
bjp-13842	11	29	,	,	PUNCT
bjp-13842	11	30	a	a	DET
bjp-13842	11	31	journal	journal	NOUN
bjp-13842	11	32	of	of	ADP
bjp-13842	11	33	the	the	DET
bjp-13842	11	34	bangladesh	bangladesh	NOUN
bjp-13842	11	35	pharmacological	pharmacological	ADJ
bjp-13842	11	36	society	society	NOUN
bjp-13842	11	37	(	(	PUNCT
bjp-13842	11	38	bdps	bdps	NOUN
bjp-13842	11	39	)	)	PUNCT
bjp-13842	11	40	bangladesh	bangladesh	PROPN
bjp-13842	11	41	j	j	PROPN
bjp-13842	11	42	pharmacol	pharmacol	PROPN
bjp-13842	11	43	2013	2013	NUM
bjp-13842	11	44	;	;	PUNCT
bjp-13842	11	45	8	8	NUM
bjp-13842	11	46	:	:	SYM
bjp-13842	11	47	142	142	NUM
bjp-13842	11	48	-	-	SYM
bjp-13842	11	49	148	148	NUM
bjp-13842	11	50	journal	journal	NOUN
bjp-13842	11	51	homepage	homepage	NOUN
bjp-13842	11	52	:	:	PUNCT
bjp-13842	11	53	www.banglajol.info	www.banglajol.info	PROPN
bjp-13842	11	54	abstracted	abstract	VERB
bjp-13842	11	55	/	/	SYM
bjp-13842	11	56	indexed	index	VERB
bjp-13842	11	57	in	in	ADP
bjp-13842	11	58	academic	academic	ADJ
bjp-13842	11	59	search	search	NOUN
bjp-13842	11	60	complete	complete	ADJ
bjp-13842	11	61	,	,	PUNCT
bjp-13842	11	62	agroforestry	agroforestry	NOUN
bjp-13842	11	63	abstracts	abstract	NOUN
bjp-13842	11	64	,	,	PUNCT
bjp-13842	11	65	asia	asia	PROPN
bjp-13842	11	66	journals	journal	NOUN
bjp-13842	11	67	online	online	ADV
bjp-13842	11	68	,	,	PUNCT
bjp-13842	11	69	bangladesh	bangladesh	NOUN
bjp-13842	11	70	journals	journal	NOUN
bjp-13842	11	71	online	online	ADV
bjp-13842	11	72	,	,	PUNCT
bjp-13842	11	73	biological	biological	ADJ
bjp-13842	11	74	abstracts	abstract	NOUN
bjp-13842	11	75	,	,	PUNCT
bjp-13842	11	76	biosis	biosis	NOUN
bjp-13842	11	77	previews	preview	NOUN
bjp-13842	11	78	,	,	PUNCT
bjp-13842	11	79	cab	cab	NOUN
bjp-13842	11	80	abstracts	abstract	NOUN
bjp-13842	11	81	,	,	PUNCT
bjp-13842	11	82	current	current	ADJ
bjp-13842	11	83	abstracts	abstract	NOUN
bjp-13842	11	84	,	,	PUNCT
bjp-13842	11	85	directory	directory	NOUN
bjp-13842	11	86	of	of	ADP
bjp-13842	11	87	open	open	ADJ
bjp-13842	11	88	access	access	NOUN
bjp-13842	11	89	journals	journal	NOUN
bjp-13842	11	90	,	,	PUNCT
bjp-13842	11	91	embase	embase	NOUN
bjp-13842	11	92	/	/	SYM
bjp-13842	11	93	excerpta	excerpta	NOUN
bjp-13842	11	94	medica	medica	NOUN
bjp-13842	11	95	,	,	PUNCT
bjp-13842	11	96	global	global	ADJ
bjp-13842	11	97	health	health	NOUN
bjp-13842	11	98	,	,	PUNCT
bjp-13842	11	99	google	google	PROPN
bjp-13842	11	100	scholar	scholar	NOUN
bjp-13842	11	101	,	,	PUNCT
bjp-13842	11	102	hinari	hinari	X
bjp-13842	11	103	(	(	PUNCT
bjp-13842	11	104	who	who	PRON
bjp-13842	11	105	)	)	PUNCT
bjp-13842	11	106	,	,	PUNCT
bjp-13842	11	107	international	international	ADJ
bjp-13842	11	108	pharmaceutical	pharmaceutical	ADJ
bjp-13842	11	109	abstracts	abstract	NOUN
bjp-13842	11	110	,	,	PUNCT
bjp-13842	11	111	open	open	ADJ
bjp-13842	11	112	j	j	PROPN
bjp-13842	11	113	-	-	PUNCT
bjp-13842	11	114	gate	gate	NOUN
bjp-13842	11	115	,	,	PUNCT
bjp-13842	11	116	science	science	NOUN
bjp-13842	11	117	citation	citation	NOUN
bjp-13842	11	118	index	index	NOUN
bjp-13842	11	119	expanded	expand	VERB
bjp-13842	11	120	,	,	PUNCT
bjp-13842	11	121	scopus	scopus	NOUN
bjp-13842	11	122	and	and	CCONJ
bjp-13842	11	123	social	social	ADJ
bjp-13842	11	124	sciences	sciences	PROPN
bjp-13842	11	125	citation	citation	NOUN
bjp-13842	11	126	index	index	NOUN
bjp-13842	11	127	issn	issn	PROPN
bjp-13842	11	128	:	:	PUNCT
bjp-13842	11	129	1991	1991	NUM
bjp-13842	11	130	-	-	SYM
bjp-13842	11	131	0088	0088	NUM
bjp-13842	11	132	trichostatin	trichostatin	NOUN
bjp-13842	11	133	a	a	DET
bjp-13842	11	134	destabilizes	destabilize	NOUN
bjp-13842	11	135	hif-2α	hif-2α	NOUN
bjp-13842	11	136	through	through	ADP
bjp-13842	11	137	a	a	DET
bjp-13842	11	138	vhl	vhl	NOUN
bjp-13842	11	139	-	-	PUNCT
bjp-13842	11	140	independent	independent	ADJ
bjp-13842	11	141	but	but	CCONJ
bjp-13842	11	142	proteasome	proteasome	NOUN
bjp-13842	11	143	-	-	PUNCT
bjp-13842	11	144	dependent	dependent	ADJ
bjp-13842	11	145	pathway	pathway	NOUN
bjp-13842	11	146	in	in	ADP
bjp-13842	11	147	cancer	cancer	NOUN
bjp-13842	11	148	cell	cell	NOUN
bjp-13842	11	149	lines	line	NOUN
bjp-13842	11	150	and	and	CCONJ
bjp-13842	11	151	tumor	tumor	NOUN
bjp-13842	11	152	xenografts	xenografts	PROPN
bjp-13842	11	153	qingcheng	qingcheng	PROPN
bjp-13842	11	154	yang1	yang1	PROPN
bjp-13842	11	155	,	,	PUNCT
bjp-13842	11	156	yuzhen	yuzhen	PROPN
bjp-13842	11	157	du2	du2	PROPN
bjp-13842	11	158	,	,	PUNCT
bjp-13842	11	159	dongdong	dongdong	PROPN
bjp-13842	11	160	cheng1	cheng1	PROPN
bjp-13842	11	161	,	,	PUNCT
bjp-13842	11	162	zhichang	zhichang	PROPN
bjp-13842	11	163	zhang1	zhang1	PROPN
bjp-13842	11	164	and	and	CCONJ
bjp-13842	11	165	xinhui	xinhui	PROPN
bjp-13842	11	166	du1	du1	PROPN
bjp-13842	11	167	1department	1department	NUM
bjp-13842	11	168	of	of	ADP
bjp-13842	11	169	orthopedics	orthopedic	NOUN
bjp-13842	11	170	,	,	PUNCT
bjp-13842	11	171	sixth	sixth	ADJ
bjp-13842	11	172	people	people	NOUN
bjp-13842	11	173	’s	’s	PART
bjp-13842	11	174	hospital	hospital	NOUN
bjp-13842	11	175	,	,	PUNCT
bjp-13842	11	176	shanghai	shanghai	PROPN
bjp-13842	11	177	jiaotong	jiaotong	PROPN
bjp-13842	11	178	university	university	PROPN
bjp-13842	11	179	,	,	PUNCT
bjp-13842	11	180	shanghai	shanghai	PROPN
bjp-13842	11	181	200233	200233	NUM
bjp-13842	11	182	,	,	PUNCT
bjp-13842	11	183	china	china	PROPN
bjp-13842	11	184	;	;	PUNCT
bjp-13842	11	185	2department	2department	NUM
bjp-13842	11	186	of	of	ADP
bjp-13842	11	187	clinical	clinical	ADJ
bjp-13842	11	188	laboratory	laboratory	NOUN
bjp-13842	11	189	,	,	PUNCT
bjp-13842	11	190	sixth	sixth	ADJ
bjp-13842	11	191	people	people	NOUN
bjp-13842	11	192	’s	’s	PART
bjp-13842	11	193	hospital	hospital	NOUN
bjp-13842	11	194	,	,	PUNCT
bjp-13842	11	195	shanghai	shanghai	PROPN
bjp-13842	11	196	jiao	jiao	PROPN
bjp-13842	11	197	tong	tong	PROPN
bjp-13842	11	198	university	university	PROPN
bjp-13842	11	199	,	,	PUNCT
bjp-13842	11	200	shanghai	shanghai	PROPN
bjp-13842	11	201	200233	200233	NUM
bjp-13842	11	202	,	,	PUNCT
bjp-13842	11	203	china	china	PROPN
bjp-13842	11	204	.	.	PUNCT
bjp-13842	12	1	abstract	abstract	PROPN
bjp-13842	12	2	histone	histone	PROPN
bjp-13842	12	3	deacetylase	deacetylase	PROPN
bjp-13842	12	4	(	(	PUNCT
bjp-13842	12	5	hdacs	hdac	NOUN
bjp-13842	12	6	)	)	PUNCT
bjp-13842	12	7	inhibitors	inhibitor	NOUN
bjp-13842	12	8	are	be	AUX
bjp-13842	12	9	a	a	DET
bjp-13842	12	10	new	new	ADJ
bjp-13842	12	11	generation	generation	NOUN
bjp-13842	12	12	of	of	ADP
bjp-13842	12	13	anti	anti	ADJ
bjp-13842	12	14	-	-	ADJ
bjp-13842	12	15	cancer	cancer	ADJ
bjp-13842	12	16	agents	agent	NOUN
bjp-13842	12	17	.	.	PUNCT
bjp-13842	13	1	little	little	ADJ
bjp-13842	13	2	is	be	AUX
bjp-13842	13	3	known	know	VERB
bjp-13842	13	4	regarding	regard	VERB
bjp-13842	13	5	the	the	DET
bjp-13842	13	6	effect	effect	NOUN
bjp-13842	13	7	of	of	ADP
bjp-13842	13	8	hdac	hdac	NOUN
bjp-13842	13	9	inhibitors	inhibitor	NOUN
bjp-13842	13	10	on	on	ADP
bjp-13842	13	11	hif-2α	hif-2α	NOUN
bjp-13842	13	12	.	.	PUNCT
bjp-13842	14	1	the	the	DET
bjp-13842	14	2	effect	effect	NOUN
bjp-13842	14	3	of	of	ADP
bjp-13842	14	4	trichostatin	trichostatin	NOUN
bjp-13842	14	5	a	a	DET
bjp-13842	14	6	(	(	PUNCT
bjp-13842	14	7	tsa	tsa	PROPN
bjp-13842	14	8	)	)	PUNCT
bjp-13842	14	9	,	,	PUNCT
bjp-13842	14	10	a	a	DET
bjp-13842	14	11	class	class	NOUN
bjp-13842	14	12	i	i	PROPN
bjp-13842	14	13	/	/	SYM
bjp-13842	14	14	ii	ii	PROPN
bjp-13842	14	15	hdac	hdac	NOUN
bjp-13842	14	16	inhibitor	inhibitor	NOUN
bjp-13842	14	17	,	,	PUNCT
bjp-13842	14	18	on	on	ADP
bjp-13842	14	19	hif-2α	hif-2α	ADJ
bjp-13842	14	20	protein	protein	NOUN
bjp-13842	14	21	expression	expression	NOUN
bjp-13842	14	22	was	be	AUX
bjp-13842	14	23	investigated	investigate	VERB
bjp-13842	14	24	in	in	ADP
bjp-13842	14	25	cancer	cancer	NOUN
bjp-13842	14	26	cell	cell	NOUN
bjp-13842	14	27	lines	line	NOUN
bjp-13842	14	28	and	and	CCONJ
bjp-13842	14	29	tumor	tumor	NOUN
bjp-13842	14	30	xenografts	xenograft	NOUN
bjp-13842	14	31	.	.	PUNCT
bjp-13842	15	1	results	result	NOUN
bjp-13842	15	2	showed	show	VERB
bjp-13842	15	3	tsa	tsa	NOUN
bjp-13842	15	4	inhibited	inhibit	VERB
bjp-13842	15	5	the	the	DET
bjp-13842	15	6	hif-2α	hif-2α	ADJ
bjp-13842	15	7	protein	protein	NOUN
bjp-13842	15	8	expression	expression	NOUN
bjp-13842	15	9	in	in	ADP
bjp-13842	15	10	a	a	DET
bjp-13842	15	11	dosedependent	dosedependent	NOUN
bjp-13842	15	12	manner	manner	NOUN
bjp-13842	15	13	,	,	PUNCT
bjp-13842	15	14	which	which	PRON
bjp-13842	15	15	was	be	AUX
bjp-13842	15	16	vhl	vhl	NOUN
bjp-13842	15	17	-	-	PUNCT
bjp-13842	15	18	independent	independent	ADJ
bjp-13842	15	19	,	,	PUNCT
bjp-13842	15	20	but	but	CCONJ
bjp-13842	15	21	proteasome	proteasome	NOUN
bjp-13842	15	22	-	-	PUNCT
bjp-13842	15	23	dependent	dependent	ADJ
bjp-13842	15	24	in	in	ADP
bjp-13842	15	25	cell	cell	NOUN
bjp-13842	15	26	lines	line	NOUN
bjp-13842	15	27	.	.	PUNCT
bjp-13842	16	1	in	in	ADP
bjp-13842	16	2	tumor	tumor	NOUN
bjp-13842	16	3	xenografts	xenograft	NOUN
bjp-13842	16	4	,	,	PUNCT
bjp-13842	16	5	tsa	tsa	NOUN
bjp-13842	16	6	inhibited	inhibit	VERB
bjp-13842	16	7	tumor	tumor	NOUN
bjp-13842	16	8	growth	growth	NOUN
bjp-13842	16	9	and	and	CCONJ
bjp-13842	16	10	hif-2α	hif-2α	NOUN
bjp-13842	16	11	expression	expression	NOUN
bjp-13842	16	12	.	.	PUNCT
bjp-13842	17	1	knocking	knock	VERB
bjp-13842	17	2	down	down	ADP
bjp-13842	17	3	of	of	ADP
bjp-13842	17	4	hdac6	hdac6	NOUN
bjp-13842	17	5	by	by	ADP
bjp-13842	17	6	small	small	ADJ
bjp-13842	17	7	rna	rna	PROPN
bjp-13842	17	8	interfering	interfere	VERB
bjp-13842	17	9	decreased	decrease	VERB
bjp-13842	17	10	hif-2α	hif-2α	ADJ
bjp-13842	17	11	protein	protein	NOUN
bjp-13842	17	12	expression	expression	NOUN
bjp-13842	17	13	.	.	PUNCT
bjp-13842	18	1	hdac6	hdac6	PROPN
bjp-13842	18	2	physically	physically	ADV
bjp-13842	18	3	interracted	interracte	VERB
bjp-13842	18	4	with	with	ADP
bjp-13842	18	5	hif-2α	hif-2α	NOUN
bjp-13842	18	6	,	,	PUNCT
bjp-13842	18	7	and	and	CCONJ
bjp-13842	18	8	hif-2α	hif-2α	NOUN
bjp-13842	18	9	was	be	AUX
bjp-13842	18	10	acetylated	acetylate	VERB
bjp-13842	18	11	by	by	ADP
bjp-13842	18	12	tsa	tsa	PROPN
bjp-13842	18	13	.	.	PUNCT
bjp-13842	19	1	tsa	tsa	PROPN
bjp-13842	19	2	destabilizes	destabilize	VERB
bjp-13842	19	3	hif-2α	hif-2α	NOUN
bjp-13842	19	4	in	in	ADP
bjp-13842	19	5	a	a	DET
bjp-13842	19	6	proteasome	proteasome	NOUN
bjp-13842	19	7	dependent	dependent	ADJ
bjp-13842	19	8	manner	manner	NOUN
bjp-13842	19	9	,	,	PUNCT
bjp-13842	19	10	which	which	PRON
bjp-13842	19	11	is	be	AUX
bjp-13842	19	12	unrelated	unrelated	ADJ
bjp-13842	19	13	to	to	ADP
bjp-13842	19	14	vhl	vhl	PROPN
bjp-13842	19	15	,	,	PUNCT
bjp-13842	19	16	suggesting	suggest	VERB
bjp-13842	19	17	the	the	DET
bjp-13842	19	18	anticancer	anticancer	NOUN
bjp-13842	19	19	effect	effect	NOUN
bjp-13842	19	20	of	of	ADP
bjp-13842	19	21	tsa	tsa	NOUN
bjp-13842	19	22	is	be	AUX
bjp-13842	19	23	at	at	ADV
bjp-13842	19	24	least	least	ADV
bjp-13842	19	25	partially	partially	ADV
bjp-13842	19	26	mediated	mediate	VERB
bjp-13842	19	27	by	by	ADP
bjp-13842	19	28	its	its	PRON
bjp-13842	19	29	inhibition	inhibition	NOUN
bjp-13842	19	30	of	of	ADP
bjp-13842	19	31	hif-2α	hif-2α	NOUN
bjp-13842	19	32	,	,	PUNCT
bjp-13842	19	33	which	which	PRON
bjp-13842	19	34	provides	provide	VERB
bjp-13842	19	35	a	a	DET
bjp-13842	19	36	new	new	ADJ
bjp-13842	19	37	insight	insight	NOUN
bjp-13842	19	38	into	into	ADP
bjp-13842	19	39	the	the	DET
bjp-13842	19	40	molecular	molecular	ADJ
bjp-13842	19	41	mechanism	mechanism	NOUN
bjp-13842	19	42	underlying	underlie	VERB
bjp-13842	19	43	the	the	DET
bjp-13842	19	44	anticancer	anticancer	NOUN
bjp-13842	19	45	effect	effect	NOUN
bjp-13842	19	46	of	of	ADP
bjp-13842	19	47	hdac	hdac	NOUN
bjp-13842	19	48	inhibitors	inhibitor	NOUN
bjp-13842	19	49	.	.	PUNCT
bjp-13842	20	1	article	article	NOUN
bjp-13842	20	2	info	info	NOUN
bjp-13842	20	3	received	receive	VERB
bjp-13842	20	4	:	:	PUNCT
bjp-13842	20	5	18	18	NUM
bjp-13842	20	6	february	february	NOUN
bjp-13842	20	7	2013	2013	NUM
bjp-13842	20	8	accepted	accept	VERB
bjp-13842	20	9	:	:	PUNCT
bjp-13842	21	1	25	25	NUM
bjp-13842	21	2	february	february	PROPN
bjp-13842	21	3	2013	2013	NUM
bjp-13842	21	4	available	available	ADJ
bjp-13842	21	5	online	online	NOUN
bjp-13842	21	6	:	:	PUNCT
bjp-13842	21	7	25	25	NUM
bjp-13842	21	8	march	march	PROPN
bjp-13842	21	9	2013	2013	NUM
bjp-13842	21	10	doi	doi	NOUN
bjp-13842	21	11	:	:	PUNCT
bjp-13842	21	12	10.3329	10.3329	NUM
bjp-13842	21	13	/	/	SYM
bjp-13842	21	14	bjp.v8i2.13842	bjp.v8i2.13842	PROPN
bjp-13842	21	15	cite	cite	VERB
bjp-13842	21	16	this	this	DET
bjp-13842	21	17	article	article	NOUN
bjp-13842	21	18	:	:	PUNCT
bjp-13842	22	1	yang	yang	PROPN
bjp-13842	22	2	q	q	PROPN
bjp-13842	22	3	,	,	PUNCT
bjp-13842	22	4	du	du	PROPN
bjp-13842	22	5	y	y	PROPN
bjp-13842	22	6	,	,	PUNCT
bjp-13842	22	7	cheng	cheng	PROPN
bjp-13842	22	8	d	d	PROPN
bjp-13842	22	9	,	,	PUNCT
bjp-13842	22	10	zhang	zhang	PROPN
bjp-13842	22	11	z	z	PROPN
bjp-13842	22	12	,	,	PUNCT
bjp-13842	22	13	du	du	PROPN
bjp-13842	22	14	x.	x.	PROPN
bjp-13842	22	15	trichostatin	trichostatin	NOUN
bjp-13842	22	16	a	a	DET
bjp-13842	22	17	destabilizes	destabilize	NOUN
bjp-13842	22	18	hif-2α	hif-2α	NOUN
bjp-13842	22	19	through	through	ADP
bjp-13842	22	20	a	a	DET
bjp-13842	22	21	vhl	vhl	NOUN
bjp-13842	22	22	-	-	PUNCT
bjp-13842	22	23	independent	independent	ADJ
bjp-13842	22	24	but	but	CCONJ
bjp-13842	22	25	proteasome	proteasome	NOUN
bjp-13842	22	26	-	-	PUNCT
bjp-13842	22	27	dependent	dependent	ADJ
bjp-13842	22	28	pathway	pathway	NOUN
bjp-13842	22	29	in	in	ADP
bjp-13842	22	30	cancer	cancer	NOUN
bjp-13842	22	31	cell	cell	NOUN
bjp-13842	22	32	lines	line	NOUN
bjp-13842	22	33	and	and	CCONJ
bjp-13842	22	34	tumor	tumor	NOUN
bjp-13842	22	35	xenografts	xenograft	NOUN
bjp-13842	22	36	.	.	PUNCT
bjp-13842	23	1	bangladesh	bangladesh	PROPN
bjp-13842	23	2	j	j	PROPN
bjp-13842	23	3	pharmacol	pharmacol	PROPN
bjp-13842	23	4	.	.	PUNCT
bjp-13842	24	1	2013	2013	NUM
bjp-13842	24	2	;	;	PUNCT
bjp-13842	24	3	8	8	NUM
bjp-13842	24	4	:	:	SYM
bjp-13842	24	5	142	142	NUM
bjp-13842	24	6	-	-	SYM
bjp-13842	24	7	48	48	NUM
bjp-13842	24	8	.	.	PUNCT
bjp-13842	25	1	this	this	DET
bjp-13842	25	2	ork	ork	NOUN
bjp-13842	25	3	is	be	AUX
bjp-13842	25	4	li	li	PROPN
bjp-13842	25	5	e	e	PROPN
bjp-13842	25	6	sed	se	VERB
bjp-13842	25	7	u	u	PROPN
bjp-13842	25	8	der	der	NOUN
bjp-13842	25	9	a	a	DET
bjp-13842	25	10	creati	creati	PROPN
bjp-13842	25	11	e	e	X
bjp-13842	25	12	co	co	NOUN
bjp-13842	25	13	o	o	PROPN
bjp-13842	25	14	s	s	VERB
bjp-13842	25	15	attri	attri	ADJ
bjp-13842	25	16	utio	utio	VERB
bjp-13842	25	17	3.0	3.0	NUM
bjp-13842	25	18	li	li	NOUN
bjp-13842	25	19	e	e	X
bjp-13842	25	20	se	se	PROPN
bjp-13842	25	21	.	.	PUNCT
bjp-13842	26	1	you	you	PRON
bjp-13842	26	2	are	be	AUX
bjp-13842	26	3	free	free	ADJ
bjp-13842	26	4	to	to	PART
bjp-13842	26	5	opy	opy	VERB
bjp-13842	26	6	,	,	PUNCT
bjp-13842	26	7	distri	distri	VERB
bjp-13842	26	8	ute	ute	PROPN
bjp-13842	26	9	a	a	PROPN
bjp-13842	27	1	d	d	X
bjp-13842	27	2	perfor	perfor	ADP
bjp-13842	27	3	the	the	DET
bjp-13842	27	4	ork	ork	NOUN
bjp-13842	27	5	.	.	PUNCT
bjp-13842	28	1	you	you	PRON
bjp-13842	28	2	ust	ust	PROPN
bjp-13842	28	3	attri	attri	PROPN
bjp-13842	28	4	ute	ute	PROPN
bjp-13842	28	5	the	the	DET
bjp-13842	28	6	ork	ork	NOUN
bjp-13842	29	1	i	i	PRON
bjp-13842	29	2	the	the	DET
bjp-13842	29	3	a	a	DET
bjp-13842	29	4	er	er	INTJ
bjp-13842	29	5	spe	spe	PROPN
bjp-13842	29	6	ified	ified	PROPN
bjp-13842	29	7	y	y	PROPN
bjp-13842	29	8	the	the	DET
bjp-13842	29	9	author	author	NOUN
bjp-13842	29	10	or	or	CCONJ
bjp-13842	29	11	li	li	PROPN
bjp-13842	29	12	e	e	PROPN
bjp-13842	29	13	sor	sor	NOUN
bjp-13842	29	14	.	.	PROPN
bjp-13842	29	15	2000	2000	NUM
bjp-13842	29	16	)	)	PUNCT
bjp-13842	29	17	.	.	PUNCT
bjp-13842	30	1	there	there	PRON
bjp-13842	30	2	are	be	VERB
bjp-13842	30	3	two	two	NUM
bjp-13842	30	4	structurally	structurally	ADV
bjp-13842	30	5	related	relate	VERB
bjp-13842	30	6	hif	hif	PROPN
bjp-13842	30	7	factors	factor	NOUN
bjp-13842	30	8	termed	term	VERB
bjp-13842	30	9	hif-1α	hif-1α	NOUN
bjp-13842	30	10	and	and	CCONJ
bjp-13842	30	11	hif-2α	hif-2α	NOUN
bjp-13842	30	12	.	.	PUNCT
bjp-13842	31	1	despite	despite	SCONJ
bjp-13842	31	2	their	their	PRON
bjp-13842	31	3	sequence	sequence	NOUN
bjp-13842	31	4	homology	homology	NOUN
bjp-13842	31	5	and	and	CCONJ
bjp-13842	31	6	identical	identical	ADJ
bjp-13842	31	7	dna	dna	NOUN
bjp-13842	31	8	-	-	PUNCT
bjp-13842	31	9	binding	bind	VERB
bjp-13842	31	10	sites	site	NOUN
bjp-13842	31	11	,	,	PUNCT
bjp-13842	31	12	both	both	CCONJ
bjp-13842	31	13	hif1α	hif1α	PROPN
bjp-13842	31	14	and	and	CCONJ
bjp-13842	31	15	hif-2α	hif-2α	NOUN
bjp-13842	31	16	have	have	VERB
bjp-13842	31	17	distinct	distinct	ADJ
bjp-13842	31	18	distributions	distribution	NOUN
bjp-13842	31	19	and	and	CCONJ
bjp-13842	31	20	appear	appear	VERB
bjp-13842	31	21	to	to	PART
bjp-13842	31	22	activate	activate	VERB
bjp-13842	31	23	different	different	ADJ
bjp-13842	31	24	genes	gene	NOUN
bjp-13842	31	25	,	,	PUNCT
bjp-13842	31	26	thus	thus	ADV
bjp-13842	31	27	playing	play	VERB
bjp-13842	31	28	critical	critical	ADJ
bjp-13842	31	29	but	but	CCONJ
bjp-13842	31	30	distinct	distinct	ADJ
bjp-13842	31	31	roles	role	NOUN
bjp-13842	31	32	in	in	ADP
bjp-13842	31	33	tumor	tumor	NOUN
bjp-13842	31	34	progression	progression	NOUN
bjp-13842	31	35	(	(	PUNCT
bjp-13842	31	36	qing	qing	NOUN
bjp-13842	31	37	and	and	CCONJ
bjp-13842	31	38	simon	simon	PROPN
bjp-13842	31	39	,	,	PUNCT
bjp-13842	31	40	2009	2009	NUM
bjp-13842	31	41	)	)	PUNCT
bjp-13842	31	42	.	.	PUNCT
bjp-13842	32	1	previous	previous	ADJ
bjp-13842	32	2	studies	study	NOUN
bjp-13842	32	3	have	have	AUX
bjp-13842	32	4	demonstrated	demonstrate	VERB
bjp-13842	32	5	that	that	SCONJ
bjp-13842	32	6	hif-1	hif-1	NUM
bjp-13842	32	7	and	and	CCONJ
bjp-13842	32	8	hif-2	hif-2	X
bjp-13842	32	9	are	be	AUX
bjp-13842	32	10	over	over	ADV
bjp-13842	32	11	-	-	PUNCT
bjp-13842	32	12	expressed	express	VERB
bjp-13842	32	13	in	in	ADP
bjp-13842	32	14	some	some	DET
bjp-13842	32	15	primary	primary	ADJ
bjp-13842	32	16	and	and	CCONJ
bjp-13842	32	17	metastatic	metastatic	ADJ
bjp-13842	32	18	tumors	tumor	NOUN
bjp-13842	32	19	and	and	CCONJ
bjp-13842	32	20	their	their	PRON
bjp-13842	32	21	expression	expression	NOUN
bjp-13842	32	22	is	be	AUX
bjp-13842	32	23	closely	closely	ADV
bjp-13842	32	24	correlated	correlate	VERB
bjp-13842	32	25	with	with	ADP
bjp-13842	32	26	adverse	adverse	ADJ
bjp-13842	32	27	prognosis	prognosis	NOUN
bjp-13842	32	28	and	and	CCONJ
bjp-13842	32	29	poor	poor	ADJ
bjp-13842	32	30	response	response	NOUN
bjp-13842	32	31	to	to	ADP
bjp-13842	32	32	chemotherapy	chemotherapy	NOUN
bjp-13842	32	33	and/or	and/or	CCONJ
bjp-13842	32	34	radiotherapy	radiotherapy	PROPN
bjp-13842	32	35	(	(	PUNCT
bjp-13842	32	36	semenza	semenza	PROPN
bjp-13842	32	37	,	,	PUNCT
bjp-13842	32	38	2008	2008	NUM
bjp-13842	32	39	;	;	PUNCT
bjp-13842	32	40	bertout	bertout	VERB
bjp-13842	32	41	et	et	PROPN
bjp-13842	32	42	al	al	PROPN
bjp-13842	32	43	.	.	PROPN
bjp-13842	32	44	,	,	PUNCT
bjp-13842	32	45	2008	2008	NUM
bjp-13842	32	46	;	;	PUNCT
bjp-13842	32	47	semenza	semenza	NUM
bjp-13842	32	48	,	,	PUNCT
bjp-13842	32	49	2010	2010	NUM
bjp-13842	32	50	)	)	PUNCT
bjp-13842	32	51	.	.	PUNCT
bjp-13842	33	1	hif-1α	hif-1α	NOUN
bjp-13842	33	2	and	and	CCONJ
bjp-13842	33	3	hif-2α	hif-2α	NOUN
bjp-13842	33	4	exert	exert	ADJ
bjp-13842	33	5	effects	effect	NOUN
bjp-13842	33	6	on	on	ADP
bjp-13842	33	7	cancer	cancer	NOUN
bjp-13842	33	8	progression	progression	NOUN
bjp-13842	33	9	by	by	ADP
bjp-13842	33	10	binding	bind	VERB
bjp-13842	33	11	to	to	ADP
bjp-13842	33	12	and	and	CCONJ
bjp-13842	33	13	activating	activate	VERB
bjp-13842	33	14	target	target	NOUN
bjp-13842	33	15	genes	gene	NOUN
bjp-13842	33	16	with	with	ADP
bjp-13842	33	17	cis	cis	NOUN
bjp-13842	33	18	-	-	PUNCT
bjp-13842	33	19	acting	act	VERB
bjp-13842	33	20	hypoxia	hypoxia	NOUN
bjp-13842	33	21	response	response	NOUN
bjp-13842	33	22	elements	element	NOUN
bjp-13842	33	23	containing	contain	VERB
bjp-13842	33	24	the	the	DET
bjp-13842	33	25	consensus	consensus	NOUN
bjp-13842	33	26	binding	bind	VERB
bjp-13842	33	27	site	site	NOUN
bjp-13842	33	28	5’-rcgtg-3	5’-rcgtg-3	PROPN
bjp-13842	33	29	’	'	PUNCT
bjp-13842	33	30	.	.	PUNCT
bjp-13842	34	1	a	a	DET
bjp-13842	34	2	variety	variety	NOUN
bjp-13842	34	3	of	of	ADP
bjp-13842	34	4	genes	gene	NOUN
bjp-13842	34	5	that	that	PRON
bjp-13842	34	6	are	be	AUX
bjp-13842	34	7	induced	induce	VERB
bjp-13842	34	8	by	by	ADP
bjp-13842	34	9	hypoxia	hypoxia	NOUN
bjp-13842	34	10	in	in	ADP
bjp-13842	34	11	an	an	DET
bjp-13842	34	12	hif-1	hif-1	ADV
bjp-13842	34	13	-	-	PUNCT
bjp-13842	34	14	dependent	dependent	ADJ
bjp-13842	34	15	manner	manner	NOUN
bjp-13842	34	16	encode	encode	ADJ
bjp-13842	34	17	proteins	protein	NOUN
bjp-13842	34	18	which	which	PRON
bjp-13842	34	19	have	have	VERB
bjp-13842	34	20	key	key	ADJ
bjp-13842	34	21	roles	role	NOUN
bjp-13842	34	22	in	in	ADP
bjp-13842	34	23	the	the	DET
bjp-13842	34	24	cancer	cancer	NOUN
bjp-13842	34	25	biology	biology	NOUN
bjp-13842	34	26	,	,	PUNCT
bjp-13842	34	27	including	include	VERB
bjp-13842	34	28	angiogenesis	angiogenesis	NOUN
bjp-13842	34	29	,	,	PUNCT
bjp-13842	34	30	glucose	glucose	NOUN
bjp-13842	34	31	metabolism	metabolism	NOUN
bjp-13842	34	32	,	,	PUNCT
bjp-13842	34	33	microenvironment	microenvironment	ADJ
bjp-13842	34	34	remodeling	remodeling	NOUN
bjp-13842	34	35	and	and	CCONJ
bjp-13842	34	36	other	other	ADJ
bjp-13842	34	37	changes	change	NOUN
bjp-13842	34	38	required	require	VERB
bjp-13842	34	39	for	for	ADP
bjp-13842	34	40	tumor	tumor	NOUN
bjp-13842	34	41	progression	progression	NOUN
bjp-13842	34	42	(	(	PUNCT
bjp-13842	34	43	semenza	semenza	NOUN
bjp-13842	34	44	,	,	PUNCT
bjp-13842	34	45	2010	2010	NUM
bjp-13842	34	46	)	)	PUNCT
bjp-13842	34	47	.	.	PUNCT
bjp-13842	35	1	because	because	SCONJ
bjp-13842	35	2	of	of	ADP
bjp-13842	35	3	its	its	PRON
bjp-13842	35	4	pivotal	pivotal	ADJ
bjp-13842	35	5	roles	role	NOUN
bjp-13842	35	6	in	in	ADP
bjp-13842	35	7	tumor	tumor	NOUN
bjp-13842	35	8	progression	progression	NOUN
bjp-13842	35	9	,	,	PUNCT
bjp-13842	35	10	hif	hif	PROPN
bjp-13842	35	11	has	have	AUX
bjp-13842	35	12	been	be	AUX
bjp-13842	35	13	considered	consider	VERB
bjp-13842	35	14	as	as	ADP
bjp-13842	35	15	a	a	DET
bjp-13842	35	16	potential	potential	ADJ
bjp-13842	35	17	target	target	NOUN
bjp-13842	35	18	for	for	ADP
bjp-13842	35	19	cancer	cancer	NOUN
bjp-13842	35	20	therapy	therapy	NOUN
bjp-13842	35	21	,	,	PUNCT
bjp-13842	35	22	and	and	CCONJ
bjp-13842	35	23	many	many	ADJ
bjp-13842	35	24	hif	hif	PROPN
bjp-13842	35	25	inhibitors	inhibitor	NOUN
bjp-13842	35	26	have	have	AUX
bjp-13842	35	27	been	be	AUX
bjp-13842	35	28	screened	screen	VERB
bjp-13842	35	29	and	and	CCONJ
bjp-13842	35	30	tested	test	VERB
bjp-13842	35	31	in	in	ADP
bjp-13842	35	32	cancers	cancer	NOUN
bjp-13842	35	33	(	(	PUNCT
bjp-13842	35	34	melillo	melillo	PROPN
bjp-13842	35	35	,	,	PUNCT
bjp-13842	35	36	2007	2007	NUM
bjp-13842	35	37	)	)	PUNCT
bjp-13842	35	38	.	.	PUNCT
bjp-13842	36	1	histone	histone	NOUN
bjp-13842	36	2	deacetylase	deacetylase	PROPN
bjp-13842	36	3	(	(	PUNCT
bjp-13842	36	4	hdac	hdac	NOUN
bjp-13842	36	5	)	)	PUNCT
bjp-13842	36	6	inhibitors	inhibitor	NOUN
bjp-13842	36	7	are	be	AUX
bjp-13842	36	8	a	a	DET
bjp-13842	36	9	relatively	relatively	ADV
bjp-13842	36	10	new	new	ADJ
bjp-13842	36	11	class	class	NOUN
bjp-13842	36	12	of	of	ADP
bjp-13842	36	13	anti	anti	ADJ
bjp-13842	36	14	-	-	ADJ
bjp-13842	36	15	cancer	cancer	ADJ
bjp-13842	36	16	agents	agent	NOUN
bjp-13842	36	17	that	that	PRON
bjp-13842	36	18	play	play	VERB
bjp-13842	36	19	important	important	ADJ
bjp-13842	36	20	roles	role	NOUN
bjp-13842	36	21	in	in	ADP
bjp-13842	36	22	the	the	DET
bjp-13842	36	23	regulation	regulation	NOUN
bjp-13842	36	24	of	of	ADP
bjp-13842	36	25	epigenesis	epigenesis	NOUN
bjp-13842	36	26	and	and	CCONJ
bjp-13842	36	27	non	non	NOUN
bjp-13842	36	28	-	-	NOUN
bjp-13842	36	29	epigenesis	epigenesis	NOUN
bjp-13842	36	30	including	include	VERB
bjp-13842	36	31	death	death	NOUN
bjp-13842	36	32	,	,	PUNCT
bjp-13842	36	33	apoptosis	apoptosis	NOUN
bjp-13842	36	34	and	and	CCONJ
bjp-13842	36	35	cell	cell	NOUN
bjp-13842	36	36	cycle	cycle	NOUN
bjp-13842	36	37	arrest	arrest	NOUN
bjp-13842	36	38	in	in	ADP
bjp-13842	36	39	cancer	cancer	NOUN
bjp-13842	36	40	cells	cell	NOUN
bjp-13842	36	41	.	.	PUNCT
bjp-13842	37	1	recently	recently	ADV
bjp-13842	37	2	,	,	PUNCT
bjp-13842	37	3	hdac	hdac	PROPN
bjp-13842	37	4	inhibitors	inhibitor	NOUN
bjp-13842	37	5	have	have	AUX
bjp-13842	37	6	been	be	AUX
bjp-13842	37	7	clinically	clinically	ADV
bjp-13842	37	8	applied	apply	VERB
bjp-13842	37	9	in	in	ADP
bjp-13842	37	10	cancer	cancer	NOUN
bjp-13842	37	11	patients	patient	NOUN
bjp-13842	37	12	and	and	CCONJ
bjp-13842	37	13	two	two	NUM
bjp-13842	37	14	hdac	hdac	NOUN
bjp-13842	37	15	inhibitors	inhibitor	NOUN
bjp-13842	37	16	have	have	AUX
bjp-13842	37	17	been	be	AUX
bjp-13842	37	18	approved	approve	VERB
bjp-13842	37	19	by	by	ADP
bjp-13842	37	20	the	the	DET
bjp-13842	37	21	fda	fda	PROPN
bjp-13842	37	22	.	.	PUNCT
bjp-13842	38	1	however	however	ADV
bjp-13842	38	2	,	,	PUNCT
bjp-13842	38	3	the	the	DET
bjp-13842	38	4	molecular	molecular	ADJ
bjp-13842	38	5	mechanisms	mechanism	NOUN
bjp-13842	38	6	underlying	underlie	VERB
bjp-13842	38	7	the	the	DET
bjp-13842	38	8	therapeutic	therapeutic	ADJ
bjp-13842	38	9	effect	effect	NOUN
bjp-13842	38	10	of	of	ADP
bjp-13842	38	11	hdac	hdac	NOUN
bjp-13842	38	12	inhibitors	inhibitor	NOUN
bjp-13842	38	13	on	on	ADP
bjp-13842	38	14	cancers	cancer	NOUN
bjp-13842	38	15	are	be	AUX
bjp-13842	38	16	not	not	PART
bjp-13842	38	17	fully	fully	ADV
bjp-13842	38	18	understood	understand	VERB
bjp-13842	38	19	(	(	PUNCT
bjp-13842	38	20	kim	kim	PROPN
bjp-13842	38	21	and	and	CCONJ
bjp-13842	38	22	bae	bae	PROPN
bjp-13842	38	23	,	,	PUNCT
bjp-13842	38	24	2011	2011	NUM
bjp-13842	38	25	)	)	PUNCT
bjp-13842	38	26	.	.	PUNCT
bjp-13842	39	1	recent	recent	ADJ
bjp-13842	39	2	findings	finding	NOUN
bjp-13842	39	3	indicate	indicate	VERB
bjp-13842	39	4	that	that	SCONJ
bjp-13842	39	5	several	several	ADJ
bjp-13842	39	6	hdac	hdac	NOUN
bjp-13842	39	7	inhibitors	inhibitor	NOUN
bjp-13842	39	8	can	can	AUX
bjp-13842	39	9	inhibit	inhibit	VERB
bjp-13842	39	10	the	the	DET
bjp-13842	39	11	angiogenesis	angiogenesis	NOUN
bjp-13842	39	12	,	,	PUNCT
bjp-13842	39	13	a	a	DET
bjp-13842	39	14	process	process	NOUN
bjp-13842	39	15	essential	essential	ADJ
bjp-13842	39	16	for	for	ADP
bjp-13842	39	17	tumor	tumor	NOUN
bjp-13842	39	18	metabolism	metabolism	NOUN
bjp-13842	39	19	and	and	CCONJ
bjp-13842	39	20	progression	progression	NOUN
bjp-13842	39	21	.	.	PUNCT
bjp-13842	40	1	accumulating	accumulate	VERB
bjp-13842	40	2	evidence	evidence	NOUN
bjp-13842	40	3	supports	support	VERB
bjp-13842	40	4	that	that	SCONJ
bjp-13842	40	5	the	the	DET
bjp-13842	40	6	inhibition	inhibition	NOUN
bjp-13842	40	7	of	of	ADP
bjp-13842	40	8	angiogenesis	angiogenesis	NOUN
bjp-13842	40	9	is	be	AUX
bjp-13842	40	10	at	at	ADV
bjp-13842	40	11	least	least	ADJ
bjp-13842	40	12	partially	partially	ADV
bjp-13842	40	13	mediated	mediate	VERB
bjp-13842	40	14	by	by	ADP
bjp-13842	40	15	hif	hif	PROPN
bjp-13842	40	16	(	(	PUNCT
bjp-13842	40	17	chen	chen	PROPN
bjp-13842	40	18	and	and	CCONJ
bjp-13842	40	19	sang	sing	VERB
bjp-13842	40	20	,	,	PUNCT
bjp-13842	40	21	2011	2011	NUM
bjp-13842	40	22	;	;	PUNCT
bjp-13842	40	23	liang	liang	PROPN
bjp-13842	40	24	et	et	PROPN
bjp-13842	40	25	al	al	PROPN
bjp-13842	40	26	.	.	PROPN
bjp-13842	40	27	,	,	PUNCT
bjp-13842	40	28	2006	2006	NUM
bjp-13842	40	29	)	)	PUNCT
bjp-13842	40	30	.	.	PUNCT
bjp-13842	41	1	previous	previous	ADJ
bjp-13842	41	2	studies	study	NOUN
bjp-13842	41	3	have	have	AUX
bjp-13842	41	4	shown	show	VERB
bjp-13842	41	5	that	that	SCONJ
bjp-13842	41	6	hdac	hdac	NOUN
bjp-13842	41	7	inhibitors	inhibitor	NOUN
bjp-13842	41	8	not	not	PART
bjp-13842	41	9	only	only	ADV
bjp-13842	41	10	destablize	destablize	VERB
bjp-13842	41	11	hif-1α	hif-1α	NOUN
bjp-13842	41	12	protein	protein	NOUN
bjp-13842	41	13	expression	expression	NOUN
bjp-13842	41	14	(	(	PUNCT
bjp-13842	41	15	qian	qian	PROPN
bjp-13842	41	16	et	et	PROPN
bjp-13842	41	17	al	al	PROPN
bjp-13842	41	18	.	.	PROPN
bjp-13842	41	19	,	,	PUNCT
bjp-13842	41	20	2004	2004	NUM
bjp-13842	41	21	;	;	PUNCT
bjp-13842	42	1	qian	qian	PROPN
bjp-13842	42	2	et	et	PROPN
bjp-13842	42	3	al	al	PROPN
bjp-13842	42	4	.	.	PROPN
bjp-13842	42	5	,	,	PUNCT
bjp-13842	42	6	2006	2006	NUM
bjp-13842	42	7	;	;	PUNCT
bjp-13842	42	8	kong	kong	PROPN
bjp-13842	42	9	et	et	PROPN
bjp-13842	42	10	al	al	PROPN
bjp-13842	42	11	.	.	PROPN
bjp-13842	42	12	,	,	PUNCT
bjp-13842	42	13	2006	2006	NUM
bjp-13842	42	14	)	)	PUNCT
bjp-13842	42	15	,	,	PUNCT
bjp-13842	42	16	but	but	CCONJ
bjp-13842	42	17	inhibit	inhibit	VERB
bjp-13842	42	18	the	the	DET
bjp-13842	42	19	hif-1α	hif-1α	NOUN
bjp-13842	42	20	transcriptional	transcriptional	NOUN
bjp-13842	42	21	activity	activity	NOUN
bjp-13842	42	22	(	(	PUNCT
bjp-13842	42	23	fath	fath	PROPN
bjp-13842	42	24	et	et	PROPN
bjp-13842	42	25	al	al	PROPN
bjp-13842	42	26	.	.	PROPN
bjp-13842	42	27	,	,	PUNCT
bjp-13842	42	28	2006	2006	NUM
bjp-13842	42	29	)	)	PUNCT
bjp-13842	42	30	.	.	PUNCT
bjp-13842	43	1	however	however	ADV
bjp-13842	43	2	,	,	PUNCT
bjp-13842	43	3	little	little	ADJ
bjp-13842	43	4	is	be	AUX
bjp-13842	43	5	known	know	VERB
bjp-13842	43	6	regarding	regard	VERB
bjp-13842	43	7	the	the	DET
bjp-13842	43	8	effect	effect	NOUN
bjp-13842	43	9	of	of	ADP
bjp-13842	43	10	hdac	hdac	NOUN
bjp-13842	43	11	inhibitors	inhibitor	NOUN
bjp-13842	43	12	on	on	ADP
bjp-13842	43	13	hif-2α	hif-2α	NOUN
bjp-13842	43	14	.	.	PUNCT
bjp-13842	44	1	in	in	ADP
bjp-13842	44	2	the	the	DET
bjp-13842	44	3	present	present	ADJ
bjp-13842	44	4	study	study	NOUN
bjp-13842	44	5	,	,	PUNCT
bjp-13842	44	6	our	our	PRON
bjp-13842	44	7	results	result	NOUN
bjp-13842	44	8	showed	show	VERB
bjp-13842	44	9	that	that	SCONJ
bjp-13842	44	10	hdac	hdac	NOUN
bjp-13842	44	11	inhibitor	inhibitor	NOUN
bjp-13842	44	12	tsa	tsa	NOUN
bjp-13842	44	13	could	could	AUX
bjp-13842	44	14	induce	induce	VERB
bjp-13842	44	15	hif-2α	hif-2α	ADJ
bjp-13842	44	16	degradation	degradation	NOUN
bjp-13842	44	17	in	in	ADP
bjp-13842	44	18	a	a	DET
bjp-13842	44	19	vhl	vhl	NOUN
bjp-13842	44	20	-	-	PUNCT
bjp-13842	44	21	independent	independent	ADJ
bjp-13842	44	22	but	but	CCONJ
bjp-13842	44	23	proteasome	proteasome	NOUN
bjp-13842	44	24	-	-	PUNCT
bjp-13842	44	25	dependent	dependent	ADJ
bjp-13842	44	26	pathway	pathway	NOUN
bjp-13842	44	27	,	,	PUNCT
bjp-13842	44	28	which	which	PRON
bjp-13842	44	29	is	be	AUX
bjp-13842	44	30	similar	similar	ADJ
bjp-13842	44	31	as	as	ADP
bjp-13842	44	32	the	the	DET
bjp-13842	44	33	degradation	degradation	NOUN
bjp-13842	44	34	of	of	ADP
bjp-13842	44	35	hif-1α	hif-1α	NOUN
bjp-13842	44	36	mediated	mediate	VERB
bjp-13842	44	37	by	by	ADP
bjp-13842	44	38	hdac	hdac	NOUN
bjp-13842	44	39	inhibitors	inhibitor	NOUN
bjp-13842	44	40	.	.	PUNCT
bjp-13842	45	1	materials	material	NOUN
bjp-13842	45	2	and	and	CCONJ
bjp-13842	45	3	methods	method	NOUN
bjp-13842	45	4	cell	cell	NOUN
bjp-13842	45	5	culture	culture	NOUN
bjp-13842	45	6	cell	cell	NOUN
bjp-13842	45	7	lines	line	NOUN
bjp-13842	45	8	mg-63	mg-63	NOUN
bjp-13842	45	9	,	,	PUNCT
bjp-13842	45	10	786	786	NUM
bjp-13842	45	11	-	-	SYM
bjp-13842	45	12	0	0	NUM
bjp-13842	45	13	,	,	PUNCT
bjp-13842	45	14	ht1080	ht1080	NOUN
bjp-13842	45	15	and	and	CCONJ
bjp-13842	45	16	hela	hela	PROPN
bjp-13842	45	17	were	be	AUX
bjp-13842	45	18	purchased	purchase	VERB
bjp-13842	45	19	from	from	ADP
bjp-13842	45	20	american	american	ADJ
bjp-13842	45	21	type	type	NOUN
bjp-13842	45	22	culture	culture	NOUN
bjp-13842	45	23	collection	collection	NOUN
bjp-13842	45	24	(	(	PUNCT
bjp-13842	45	25	atcc	atcc	NOUN
bjp-13842	45	26	)	)	PUNCT
bjp-13842	45	27	.	.	PUNCT
bjp-13842	46	1	cells	cell	NOUN
bjp-13842	46	2	were	be	AUX
bjp-13842	46	3	cultured	cultured	ADJ
bjp-13842	46	4	in	in	ADP
bjp-13842	46	5	dulbecco	dulbecco	NOUN
bjp-13842	46	6	’s	’s	PART
bjp-13842	46	7	modified	modified	PROPN
bjp-13842	46	8	eagle	eagle	PROPN
bjp-13842	46	9	’s	’s	PART
bjp-13842	46	10	medium	medium	ADJ
bjp-13842	46	11	(	(	PUNCT
bjp-13842	46	12	dmem	dmem	ADJ
bjp-13842	46	13	)	)	PUNCT
bjp-13842	46	14	containing	contain	VERB
bjp-13842	46	15	l	l	NOUN
bjp-13842	46	16	-	-	NOUN
bjp-13842	46	17	glutamine	glutamine	NOUN
bjp-13842	46	18	,	,	PUNCT
bjp-13842	46	19	sodium	sodium	NOUN
bjp-13842	46	20	pyruvate	pyruvate	NOUN
bjp-13842	46	21	,	,	PUNCT
bjp-13842	46	22	10	10	NUM
bjp-13842	46	23	%	%	NOUN
bjp-13842	46	24	fetal	fetal	ADJ
bjp-13842	46	25	bovine	bovine	NOUN
bjp-13842	46	26	serum	serum	NOUN
bjp-13842	46	27	(	(	PUNCT
bjp-13842	46	28	fbs	fbs	PROPN
bjp-13842	46	29	)	)	PUNCT
bjp-13842	46	30	,	,	PUNCT
bjp-13842	46	31	penicillin	penicillin	NOUN
bjp-13842	46	32	(	(	PUNCT
bjp-13842	46	33	100	100	NUM
bjp-13842	46	34	u	u	NOUN
bjp-13842	46	35	/	/	SYM
bjp-13842	46	36	ml	ml	VERB
bjp-13842	46	37	)	)	PUNCT
bjp-13842	46	38	and	and	CCONJ
bjp-13842	46	39	streptomycin	streptomycin	PROPN
bjp-13842	46	40	(	(	PUNCT
bjp-13842	46	41	100	100	NUM
bjp-13842	46	42	μg	μg	NOUN
bjp-13842	46	43	/	/	SYM
bjp-13842	46	44	ml	ml	NOUN
bjp-13842	46	45	)	)	PUNCT
bjp-13842	46	46	.	.	PUNCT
bjp-13842	47	1	cells	cell	NOUN
bjp-13842	47	2	were	be	AUX
bjp-13842	47	3	grown	grow	VERB
bjp-13842	47	4	in	in	ADP
bjp-13842	47	5	a	a	DET
bjp-13842	47	6	humidified	humidify	VERB
bjp-13842	47	7	environment	environment	NOUN
bjp-13842	47	8	containing	contain	VERB
bjp-13842	47	9	5%co2	5%co2	NUM
bjp-13842	47	10	at	at	ADP
bjp-13842	47	11	37	37	NUM
bjp-13842	47	12	°	°	NOUN
bjp-13842	47	13	c	c	NOUN
bjp-13842	47	14	.	.	PUNCT
bjp-13842	47	15	hypoxia	hypoxia	NOUN
bjp-13842	47	16	condition	condition	NOUN
bjp-13842	47	17	was	be	AUX
bjp-13842	47	18	introduced	introduce	VERB
bjp-13842	47	19	by	by	ADP
bjp-13842	47	20	using	use	VERB
bjp-13842	47	21	a	a	DET
bjp-13842	47	22	hypoxic	hypoxic	ADJ
bjp-13842	47	23	chamber	chamber	NOUN
bjp-13842	47	24	(	(	PUNCT
bjp-13842	47	25	in	in	ADP
bjp-13842	47	26	vivo2	vivo2	NOUN
bjp-13842	47	27	;	;	PUNCT
bjp-13842	47	28	ruskin	ruskin	PROPN
bjp-13842	47	29	tech	tech	PROPN
bjp-13842	47	30	)	)	PUNCT
bjp-13842	47	31	.	.	PUNCT
bjp-13842	48	1	reagents	reagent	NOUN
bjp-13842	48	2	common	common	ADJ
bjp-13842	48	3	chemicals	chemical	NOUN
bjp-13842	48	4	,	,	PUNCT
bjp-13842	48	5	solvents	solvent	NOUN
bjp-13842	48	6	,	,	PUNCT
bjp-13842	48	7	general	general	ADJ
bjp-13842	48	8	reagents	reagent	NOUN
bjp-13842	48	9	and	and	CCONJ
bjp-13842	48	10	cyclophosphamide	cyclophosphamide	NOUN
bjp-13842	48	11	(	(	PUNCT
bjp-13842	48	12	ctx	ctx	NOUN
bjp-13842	48	13	)	)	PUNCT
bjp-13842	48	14	were	be	AUX
bjp-13842	48	15	purchased	purchase	VERB
bjp-13842	48	16	from	from	ADP
bjp-13842	48	17	sigma	sigma	PROPN
bjp-13842	48	18	.	.	PUNCT
bjp-13842	49	1	tsa	tsa	NOUN
bjp-13842	49	2	and	and	CCONJ
bjp-13842	49	3	proteasome	proteasome	NOUN
bjp-13842	49	4	inhibitor	inhibitor	NOUN
bjp-13842	49	5	mg132	mg132	PROPN
bjp-13842	49	6	were	be	AUX
bjp-13842	49	7	from	from	ADP
bjp-13842	49	8	biomol	biomol	PROPN
bjp-13842	49	9	(	(	PUNCT
bjp-13842	49	10	plymouth	plymouth	NOUN
bjp-13842	49	11	meeting	meeting	NOUN
bjp-13842	49	12	,	,	PUNCT
bjp-13842	49	13	pa	pa	PROPN
bjp-13842	49	14	)	)	PUNCT
bjp-13842	49	15	.	.	PUNCT
bjp-13842	50	1	western	western	ADJ
bjp-13842	50	2	blot	blot	NOUN
bjp-13842	50	3	assay	assay	VERB
bjp-13842	50	4	and	and	CCONJ
bjp-13842	50	5	immunoprecipitation	immunoprecipitation	NOUN
bjp-13842	50	6	polyclonal	polyclonal	ADJ
bjp-13842	50	7	antibody	antibody	NOUN
bjp-13842	50	8	against	against	ADP
bjp-13842	50	9	hif-2α	hif-2α	PROPN
bjp-13842	50	10	was	be	AUX
bjp-13842	50	11	from	from	ADP
bjp-13842	50	12	novus	novus	ADJ
bjp-13842	50	13	biologicals	biological	NOUN
bjp-13842	50	14	(	(	PUNCT
bjp-13842	50	15	usa	usa	NOUN
bjp-13842	50	16	)	)	PUNCT
bjp-13842	50	17	.	.	PUNCT
bjp-13842	51	1	monoclonal	monoclonal	NOUN
bjp-13842	51	2	antibodies	antibody	NOUN
bjp-13842	51	3	against	against	ADP
bjp-13842	51	4	hdac4	hdac4	PROPN
bjp-13842	51	5	,	,	PUNCT
bjp-13842	51	6	hdac6	hdac6	PROPN
bjp-13842	51	7	,	,	PUNCT
bjp-13842	51	8	hdac7	hdac7	PROPN
bjp-13842	51	9	and	and	CCONJ
bjp-13842	51	10	α	α	X
bjp-13842	51	11	-	-	PUNCT
bjp-13842	51	12	tubulin	tubulin	NOUN
bjp-13842	51	13	were	be	AUX
bjp-13842	51	14	from	from	ADP
bjp-13842	51	15	santa	santa	PROPN
bjp-13842	51	16	cruz	cruz	PROPN
bjp-13842	51	17	biotechnology	biotechnology	PROPN
bjp-13842	51	18	(	(	PUNCT
bjp-13842	51	19	usa	usa	PROPN
bjp-13842	51	20	)	)	PUNCT
bjp-13842	51	21	.	.	PUNCT
bjp-13842	52	1	monoclonal	monoclonal	ADJ
bjp-13842	52	2	anti	anti	ADJ
bjp-13842	52	3	-	-	ADJ
bjp-13842	52	4	acetyllysine	acetyllysine	ADJ
bjp-13842	52	5	antibody	antibody	NOUN
bjp-13842	52	6	was	be	AUX
bjp-13842	52	7	from	from	ADP
bjp-13842	52	8	cell	cell	NOUN
bjp-13842	52	9	signaling	signal	VERB
bjp-13842	52	10	(	(	PUNCT
bjp-13842	52	11	canada	canada	PROPN
bjp-13842	52	12	)	)	PUNCT
bjp-13842	52	13	.	.	PUNCT
bjp-13842	53	1	monoclonal	monoclonal	NOUN
bjp-13842	53	2	antibody	antibody	NOUN
bjp-13842	53	3	against	against	ADP
bjp-13842	53	4	flag	flag	NOUN
bjp-13842	53	5	tag	tag	NOUN
bjp-13842	53	6	was	be	AUX
bjp-13842	53	7	from	from	ADP
bjp-13842	53	8	sigma	sigma	PROPN
bjp-13842	53	9	.	.	PUNCT
bjp-13842	54	1	horseradish	horseradish	ADJ
bjp-13842	54	2	peroxidase	peroxidase	NOUN
bjp-13842	54	3	conjugated	conjugate	VERB
bjp-13842	54	4	secondary	secondary	ADJ
bjp-13842	54	5	antibodies	antibody	NOUN
bjp-13842	54	6	were	be	AUX
bjp-13842	54	7	from	from	ADP
bjp-13842	54	8	sigma	sigma	NOUN
bjp-13842	54	9	and	and	CCONJ
bjp-13842	54	10	in	in	ADP
bjp-13842	54	11	vitrogen	vitrogen	PROPN
bjp-13842	54	12	.	.	PUNCT
bjp-13842	55	1	cell	cell	NOUN
bjp-13842	55	2	extracts	extract	NOUN
bjp-13842	55	3	for	for	ADP
bjp-13842	55	4	western	western	ADJ
bjp-13842	55	5	blot	blot	NOUN
bjp-13842	55	6	assay	assay	NOUN
bjp-13842	55	7	were	be	AUX
bjp-13842	55	8	obtained	obtain	VERB
bjp-13842	55	9	by	by	ADP
bjp-13842	55	10	homogenizing	homogenize	VERB
bjp-13842	55	11	cells	cell	NOUN
bjp-13842	55	12	in	in	ADP
bjp-13842	55	13	8	8	NUM
bjp-13842	55	14	m	m	NOUN
bjp-13842	55	15	urea	urea	NOUN
bjp-13842	55	16	with	with	ADP
bjp-13842	55	17	a	a	DET
bjp-13842	55	18	portable	portable	ADJ
bjp-13842	55	19	homogenator	homogenator	NOUN
bjp-13842	55	20	,	,	PUNCT
bjp-13842	55	21	which	which	PRON
bjp-13842	55	22	has	have	AUX
bjp-13842	55	23	been	be	AUX
bjp-13842	55	24	described	describe	VERB
bjp-13842	55	25	previously	previously	ADV
bjp-13842	55	26	(	(	PUNCT
bjp-13842	55	27	kong	kong	PROPN
bjp-13842	55	28	et	et	PROPN
bjp-13842	55	29	al	al	PROPN
bjp-13842	55	30	.	.	PROPN
bjp-13842	55	31	,	,	PUNCT
bjp-13842	55	32	2006	2006	NUM
bjp-13842	55	33	)	)	PUNCT
bjp-13842	55	34	.	.	PUNCT
bjp-13842	56	1	for	for	ADP
bjp-13842	56	2	western	western	ADJ
bjp-13842	56	3	blot	blot	NOUN
bjp-13842	56	4	assay	assay	VERB
bjp-13842	56	5	,	,	PUNCT
bjp-13842	56	6	40	40	NUM
bjp-13842	56	7	μg	μg	NOUN
bjp-13842	56	8	of	of	ADP
bjp-13842	56	9	cell	cell	NOUN
bjp-13842	56	10	extracts	extract	NOUN
bjp-13842	56	11	were	be	AUX
bjp-13842	56	12	loaded	load	VERB
bjp-13842	56	13	onto	onto	ADP
bjp-13842	56	14	7.5%sds	7.5%sds	NUM
bjp-13842	56	15	-	-	PUNCT
bjp-13842	56	16	polyacrylamide	polyacrylamide	NOUN
bjp-13842	56	17	gels	gel	NOUN
bjp-13842	56	18	,	,	PUNCT
bjp-13842	56	19	and	and	CCONJ
bjp-13842	56	20	proteins	protein	NOUN
bjp-13842	56	21	were	be	AUX
bjp-13842	56	22	then	then	ADV
bjp-13842	56	23	transferred	transfer	VERB
bjp-13842	56	24	onto	onto	ADP
bjp-13842	56	25	pvdf	pvdf	PROPN
bjp-13842	56	26	membranes	membrane	NOUN
bjp-13842	56	27	(	(	PUNCT
bjp-13842	56	28	bio	bio	NOUN
bjp-13842	56	29	-	-	PROPN
bjp-13842	56	30	rad	rad	PROPN
bjp-13842	56	31	,	,	PUNCT
bjp-13842	56	32	ca	ca	NOUN
bjp-13842	56	33	)	)	PUNCT
bjp-13842	56	34	which	which	PRON
bjp-13842	56	35	were	be	AUX
bjp-13842	56	36	blocked	block	VERB
bjp-13842	56	37	in	in	ADP
bjp-13842	56	38	5	5	NUM
bjp-13842	56	39	%	%	NOUN
bjp-13842	56	40	non	non	ADJ
bjp-13842	56	41	-	-	ADJ
bjp-13842	56	42	fat	fat	ADJ
bjp-13842	56	43	milk	milk	NOUN
bjp-13842	56	44	in	in	ADP
bjp-13842	56	45	tbst	tbst	PROPN
bjp-13842	56	46	followed	follow	VERB
bjp-13842	56	47	by	by	ADP
bjp-13842	56	48	incubation	incubation	NOUN
bjp-13842	56	49	overnight	overnight	ADV
bjp-13842	56	50	at	at	ADP
bjp-13842	56	51	4	4	NUM
bjp-13842	56	52	°	°	ADP
bjp-13842	56	53	c	c	NOUN
bjp-13842	56	54	with	with	ADP
bjp-13842	56	55	indicated	indicate	VERB
bjp-13842	56	56	antibodies	antibody	NOUN
bjp-13842	56	57	.	.	PUNCT
bjp-13842	57	1	immunolabeling	immunolabeling	NOUN
bjp-13842	57	2	was	be	AUX
bjp-13842	57	3	done	do	VERB
bjp-13842	57	4	with	with	ADP
bjp-13842	57	5	an	an	DET
bjp-13842	57	6	ecl	ecl	NOUN
bjp-13842	57	7	plus	plus	CCONJ
bjp-13842	57	8	kit	kit	NOUN
bjp-13842	57	9	from	from	ADP
bjp-13842	57	10	amersham	amersham	PROPN
bjp-13842	57	11	.	.	PUNCT
bjp-13842	58	1	for	for	ADP
bjp-13842	58	2	immunoprecipitation	immunoprecipitation	NOUN
bjp-13842	58	3	,	,	PUNCT
bjp-13842	58	4	cells	cell	NOUN
bjp-13842	58	5	were	be	AUX
bjp-13842	58	6	lysed	lyse	VERB
bjp-13842	58	7	on	on	ADP
bjp-13842	58	8	ice	ice	NOUN
bjp-13842	58	9	for	for	ADP
bjp-13842	58	10	1	1	NUM
bjp-13842	58	11	hour	hour	NOUN
bjp-13842	58	12	in	in	ADP
bjp-13842	58	13	ripa	ripa	ADJ
bjp-13842	58	14	lysis	lysis	NOUN
bjp-13842	58	15	buffer	buffer	NOUN
bjp-13842	58	16	with	with	ADP
bjp-13842	58	17	1	1	NUM
bjp-13842	58	18	x	x	NOUN
bjp-13842	58	19	protease	protease	NOUN
bjp-13842	58	20	inhibitor	inhibitor	NOUN
bjp-13842	58	21	,	,	PUNCT
bjp-13842	58	22	followed	follow	VERB
bjp-13842	58	23	by	by	ADP
bjp-13842	58	24	two	two	NUM
bjp-13842	58	25	freeze	freeze	ADJ
bjp-13842	58	26	-	-	PUNCT
bjp-13842	58	27	thaw	thaw	NOUN
bjp-13842	58	28	-	-	PUNCT
bjp-13842	58	29	vortex	vortex	NOUN
bjp-13842	58	30	cycles	cycle	NOUN
bjp-13842	58	31	.	.	PUNCT
bjp-13842	59	1	after	after	ADP
bjp-13842	59	2	centrifugation	centrifugation	NOUN
bjp-13842	59	3	at	at	ADP
bjp-13842	59	4	15,000x	15,000x	NUM
bjp-13842	59	5	g	g	NOUN
bjp-13842	59	6	for	for	ADP
bjp-13842	59	7	10	10	NUM
bjp-13842	59	8	min	min	NOUN
bjp-13842	59	9	,	,	PUNCT
bjp-13842	59	10	supernatants	supernatant	NOUN
bjp-13842	59	11	were	be	AUX
bjp-13842	59	12	diluted	dilute	VERB
bjp-13842	59	13	with	with	ADP
bjp-13842	59	14	lysis	lysis	NOUN
bjp-13842	59	15	buffer	buffer	NOUN
bjp-13842	59	16	and	and	CCONJ
bjp-13842	59	17	incubated	incubate	VERB
bjp-13842	59	18	with	with	ADP
bjp-13842	59	19	primary	primary	ADJ
bjp-13842	59	20	antibody	antibody	NOUN
bjp-13842	59	21	for	for	ADP
bjp-13842	59	22	4	4	NUM
bjp-13842	59	23	hours	hour	NOUN
bjp-13842	59	24	at	at	ADP
bjp-13842	59	25	4	4	NUM
bjp-13842	59	26	°	°	ADP
bjp-13842	59	27	c	c	NOUN
bjp-13842	59	28	with	with	ADP
bjp-13842	59	29	agitation	agitation	NOUN
bjp-13842	59	30	,	,	PUNCT
bjp-13842	59	31	followed	follow	VERB
bjp-13842	59	32	by	by	ADP
bjp-13842	59	33	precipitation	precipitation	NOUN
bjp-13842	59	34	with	with	ADP
bjp-13842	59	35	protein	protein	NOUN
bjp-13842	59	36	a	a	NOUN
bjp-13842	59	37	-	-	PUNCT
bjp-13842	59	38	sepharose	sepharose	NOUN
bjp-13842	59	39	(	(	PUNCT
bjp-13842	59	40	pierce	pierce	PROPN
bjp-13842	59	41	)	)	PUNCT
bjp-13842	59	42	.	.	PUNCT
bjp-13842	60	1	immunoprecipitates	immunoprecipitate	NOUN
bjp-13842	60	2	were	be	AUX
bjp-13842	60	3	washed	wash	VERB
bjp-13842	60	4	thoroughly	thoroughly	ADV
bjp-13842	60	5	with	with	ADP
bjp-13842	60	6	lysis	lysis	NOUN
bjp-13842	60	7	buffer	buffer	NOUN
bjp-13842	60	8	and	and	CCONJ
bjp-13842	60	9	subjected	subject	VERB
bjp-13842	60	10	to	to	ADP
bjp-13842	60	11	immunoblotting	immunoblotting	NOUN
bjp-13842	60	12	.	.	PUNCT
bjp-13842	61	1	sirnas	sirna	NOUN
bjp-13842	61	2	,	,	PUNCT
bjp-13842	61	3	plasmids	plasmid	NOUN
bjp-13842	61	4	and	and	CCONJ
bjp-13842	61	5	transfections	transfection	NOUN
bjp-13842	61	6	smartpool	smartpool	VERB
bjp-13842	61	7	sirnas	sirna	NOUN
bjp-13842	61	8	against	against	ADP
bjp-13842	61	9	hdac4	hdac4	PROPN
bjp-13842	61	10	,	,	PUNCT
bjp-13842	61	11	hdac6	hdac6	PROPN
bjp-13842	61	12	,	,	PUNCT
bjp-13842	61	13	hdac7	hdac7	PROPN
bjp-13842	61	14	and	and	CCONJ
bjp-13842	61	15	control	control	PROPN
bjp-13842	61	16	sirna	sirna	PROPN
bjp-13842	61	17	were	be	AUX
bjp-13842	61	18	from	from	ADP
bjp-13842	61	19	dharmacon	dharmacon	NOUN
bjp-13842	61	20	.	.	PUNCT
bjp-13842	62	1	sirna	sirna	PROPN
bjp-13842	62	2	transfection	transfection	PROPN
bjp-13842	62	3	was	be	AUX
bjp-13842	62	4	performed	perform	VERB
bjp-13842	62	5	by	by	ADP
bjp-13842	62	6	using	use	VERB
bjp-13842	62	7	the	the	DET
bjp-13842	62	8	dharmafect	dharmafect	NOUN
bjp-13842	62	9	according	accord	VERB
bjp-13842	62	10	to	to	ADP
bjp-13842	62	11	the	the	DET
bjp-13842	62	12	manufacture	manufacture	NOUN
bjp-13842	62	13	’s	’s	PART
bjp-13842	62	14	instructions	instruction	NOUN
bjp-13842	62	15	.	.	PUNCT
bjp-13842	63	1	pcmv3flag-1	pcmv3flag-1	ADJ
bjp-13842	63	2	vector	vector	NOUN
bjp-13842	63	3	was	be	AUX
bjp-13842	63	4	from	from	ADP
bjp-13842	63	5	stratagene	stratagene	NOUN
bjp-13842	63	6	(	(	PUNCT
bjp-13842	63	7	south	south	PROPN
bjp-13842	63	8	san	san	PROPN
bjp-13842	63	9	francisco	francisco	PROPN
bjp-13842	63	10	,	,	PUNCT
bjp-13842	63	11	ca	ca	NOUN
bjp-13842	63	12	)	)	PUNCT
bjp-13842	63	13	,	,	PUNCT
bjp-13842	63	14	hif-2α	hif-2α	ADJ
bjp-13842	63	15	full	full	ADJ
bjp-13842	63	16	-	-	PUNCT
bjp-13842	63	17	length	length	NOUN
bjp-13842	63	18	insert	insert	NOUN
bjp-13842	63	19	sequence	sequence	NOUN
bjp-13842	63	20	was	be	AUX
bjp-13842	63	21	generated	generate	VERB
bjp-13842	63	22	by	by	ADP
bjp-13842	63	23	pcr	pcr	NOUN
bjp-13842	63	24	using	use	VERB
bjp-13842	63	25	ht1080	ht1080	PROPN
bjp-13842	63	26	cdna	cdna	PROPN
bjp-13842	63	27	as	as	ADP
bjp-13842	63	28	the	the	DET
bjp-13842	63	29	template	template	NOUN
bjp-13842	63	30	and	and	CCONJ
bjp-13842	63	31	introduced	introduce	VERB
bjp-13842	63	32	to	to	ADP
bjp-13842	63	33	the	the	DET
bjp-13842	63	34	pcmv-3flag-1	pcmv-3flag-1	NUM
bjp-13842	63	35	vector	vector	NOUN
bjp-13842	63	36	at	at	ADP
bjp-13842	63	37	the	the	DET
bjp-13842	63	38	bamh1	bamh1	NOUN
bjp-13842	63	39	and	and	CCONJ
bjp-13842	63	40	sal1	sal1	ADJ
bjp-13842	63	41	restriction	restriction	NOUN
bjp-13842	63	42	sites	site	NOUN
bjp-13842	63	43	.	.	PUNCT
bjp-13842	64	1	flag	flag	NOUN
bjp-13842	64	2	-	-	PUNCT
bjp-13842	64	3	hif-2α	hif-2α	NOUN
bjp-13842	64	4	p405a/	p405a/	NOUN
bjp-13842	64	5	p531a	p531a	NOUN
bjp-13842	64	6	mutant	mutant	NOUN
bjp-13842	64	7	plasmid	plasmid	NOUN
bjp-13842	64	8	was	be	AUX
bjp-13842	64	9	generated	generate	VERB
bjp-13842	64	10	by	by	ADP
bjp-13842	64	11	using	use	VERB
bjp-13842	64	12	a	a	DET
bjp-13842	64	13	site	site	NOUN
bjp-13842	64	14	directed	direct	VERB
bjp-13842	64	15	mutagenesis	mutagenesis	NOUN
bjp-13842	64	16	kit	kit	NOUN
bjp-13842	64	17	from	from	ADP
bjp-13842	64	18	stratagene	stratagene	NOUN
bjp-13842	64	19	(	(	PUNCT
bjp-13842	64	20	south	south	PROPN
bjp-13842	64	21	san	san	PROPN
bjp-13842	64	22	francisco	francisco	PROPN
bjp-13842	64	23	,	,	PUNCT
bjp-13842	64	24	ca	ca	NOUN
bjp-13842	64	25	)	)	PUNCT
bjp-13842	64	26	,	,	PUNCT
bjp-13842	64	27	and	and	CCONJ
bjp-13842	64	28	all	all	DET
bjp-13842	64	29	the	the	DET
bjp-13842	64	30	plasmids	plasmid	NOUN
bjp-13842	64	31	were	be	AUX
bjp-13842	64	32	validated	validate	VERB
bjp-13842	64	33	by	by	ADP
bjp-13842	64	34	bangladesh	bangladesh	PROPN
bjp-13842	64	35	j	j	PROPN
bjp-13842	64	36	pharmacol	pharmacol	PROPN
bjp-13842	64	37	2013	2013	NUM
bjp-13842	64	38	;	;	PUNCT
bjp-13842	64	39	8	8	NUM
bjp-13842	64	40	:	:	SYM
bjp-13842	64	41	142	142	NUM
bjp-13842	64	42	-	-	SYM
bjp-13842	64	43	148	148	NUM
bjp-13842	64	44	143	143	NUM
bjp-13842	64	45	dna	dna	NOUN
bjp-13842	64	46	sequencing	sequencing	NOUN
bjp-13842	64	47	.	.	PUNCT
bjp-13842	65	1	plasmid	plasmid	NOUN
bjp-13842	65	2	transfection	transfection	NOUN
bjp-13842	65	3	was	be	AUX
bjp-13842	65	4	carried	carry	VERB
bjp-13842	65	5	out	out	ADP
bjp-13842	65	6	in	in	ADP
bjp-13842	65	7	the	the	DET
bjp-13842	65	8	presence	presence	NOUN
bjp-13842	65	9	of	of	ADP
bjp-13842	65	10	lipofectamine	lipofectamine	ADJ
bjp-13842	65	11	2000	2000	NUM
bjp-13842	65	12	(	(	PUNCT
bjp-13842	65	13	invitrogen	invitrogen	PROPN
bjp-13842	65	14	)	)	PUNCT
bjp-13842	65	15	according	accord	VERB
bjp-13842	65	16	to	to	ADP
bjp-13842	65	17	the	the	DET
bjp-13842	65	18	manufacture	manufacture	NOUN
bjp-13842	65	19	’s	’s	PART
bjp-13842	65	20	instructions	instruction	NOUN
bjp-13842	65	21	.	.	PUNCT
bjp-13842	66	1	rna	rna	NOUN
bjp-13842	66	2	isolation	isolation	NOUN
bjp-13842	66	3	and	and	CCONJ
bjp-13842	66	4	qpcr	qpcr	ADV
bjp-13842	66	5	to	to	PART
bjp-13842	66	6	analyze	analyze	VERB
bjp-13842	66	7	mrna	mrna	PROPN
bjp-13842	66	8	levels	levels	PROPN
bjp-13842	66	9	total	total	PROPN
bjp-13842	66	10	rna	rna	PROPN
bjp-13842	66	11	was	be	AUX
bjp-13842	66	12	isolated	isolate	VERB
bjp-13842	66	13	from	from	ADP
bjp-13842	66	14	cells	cell	NOUN
bjp-13842	66	15	with	with	ADP
bjp-13842	66	16	trizol	trizol	ADJ
bjp-13842	66	17	reagent	reagent	NOUN
bjp-13842	66	18	(	(	PUNCT
bjp-13842	66	19	invitrogen	invitrogen	PROPN
bjp-13842	66	20	)	)	PUNCT
bjp-13842	66	21	.	.	PUNCT
bjp-13842	67	1	rna	rna	NOUN
bjp-13842	67	2	was	be	AUX
bjp-13842	67	3	reversely	reversely	ADV
bjp-13842	67	4	transcribed	transcribe	VERB
bjp-13842	67	5	using	use	VERB
bjp-13842	67	6	random	random	ADJ
bjp-13842	67	7	hexamers	hexamer	NOUN
bjp-13842	67	8	and	and	CCONJ
bjp-13842	67	9	superscript	superscript	PROPN
bjp-13842	67	10	iii	iii	NUM
bjp-13842	67	11	reverse	reverse	ADJ
bjp-13842	67	12	transcriptase	transcriptase	NOUN
bjp-13842	67	13	(	(	PUNCT
bjp-13842	67	14	in	in	ADP
bjp-13842	67	15	vitrogen	vitrogen	NOUN
bjp-13842	67	16	)	)	PUNCT
bjp-13842	67	17	.	.	PUNCT
bjp-13842	68	1	levels	level	NOUN
bjp-13842	68	2	of	of	ADP
bjp-13842	68	3	mrna	mrna	PROPN
bjp-13842	68	4	expression	expression	NOUN
bjp-13842	68	5	were	be	AUX
bjp-13842	68	6	quantified	quantify	VERB
bjp-13842	68	7	by	by	ADP
bjp-13842	68	8	sybr	sybr	X
bjp-13842	68	9	green	green	ADJ
bjp-13842	68	10	quantitative	quantitative	ADJ
bjp-13842	68	11	reverse	reverse	ADJ
bjp-13842	68	12	transcription	transcription	NOUN
bjp-13842	68	13	–	–	PUNCT
bjp-13842	68	14	pcr	pcr	NOUN
bjp-13842	68	15	(	(	PUNCT
bjp-13842	68	16	qpcr	qpcr	ADV
bjp-13842	68	17	)	)	PUNCT
bjp-13842	68	18	using	use	VERB
bjp-13842	68	19	a	a	DET
bjp-13842	68	20	7900	7900	NUM
bjp-13842	68	21	ht	ht	DET
bjp-13842	68	22	real	real	ADJ
bjp-13842	68	23	-	-	PUNCT
bjp-13842	68	24	time	time	NOUN
bjp-13842	68	25	system	system	NOUN
bjp-13842	68	26	(	(	PUNCT
bjp-13842	68	27	applied	apply	VERB
bjp-13842	68	28	biosystems	biosystem	NOUN
bjp-13842	68	29	)	)	PUNCT
bjp-13842	68	30	.	.	PUNCT
bjp-13842	69	1	all	all	DET
bjp-13842	69	2	primer	primer	NOUN
bjp-13842	69	3	sets	set	NOUN
bjp-13842	69	4	designed	design	VERB
bjp-13842	69	5	for	for	ADP
bjp-13842	69	6	detection	detection	NOUN
bjp-13842	69	7	of	of	ADP
bjp-13842	69	8	target	target	NOUN
bjp-13842	69	9	gene	gene	NOUN
bjp-13842	69	10	mrna	mrna	NOUN
bjp-13842	69	11	by	by	ADP
bjp-13842	69	12	sybr	sybr	PROPN
bjp-13842	69	13	green	green	PROPN
bjp-13842	69	14	qpcr	qpcr	ADV
bjp-13842	69	15	were	be	AUX
bjp-13842	69	16	validated	validate	VERB
bjp-13842	69	17	for	for	ADP
bjp-13842	69	18	their	their	PRON
bjp-13842	69	19	product	product	NOUN
bjp-13842	69	20	specificity	specificity	NOUN
bjp-13842	69	21	and	and	CCONJ
bjp-13842	69	22	amplification	amplification	NOUN
bjp-13842	69	23	efficiency	efficiency	NOUN
bjp-13842	69	24	using	use	VERB
bjp-13842	69	25	melt	melt	NOUN
bjp-13842	69	26	curve	curve	NOUN
bjp-13842	69	27	analysis	analysis	NOUN
bjp-13842	69	28	,	,	PUNCT
bjp-13842	69	29	qpcr	qpcr	ADV
bjp-13842	69	30	product	product	NOUN
bjp-13842	69	31	sequencing	sequencing	NOUN
bjp-13842	69	32	and	and	CCONJ
bjp-13842	69	33	standard	standard	ADJ
bjp-13842	69	34	dilution	dilution	NOUN
bjp-13842	69	35	analysis	analysis	NOUN
bjp-13842	69	36	.	.	PUNCT
bjp-13842	70	1	primer	primer	NOUN
bjp-13842	70	2	sequences	sequence	NOUN
bjp-13842	70	3	are	be	AUX
bjp-13842	70	4	as	as	ADP
bjp-13842	70	5	the	the	DET
bjp-13842	70	6	following	following	NOUN
bjp-13842	70	7	:	:	PUNCT
bjp-13842	70	8	hif-2	hif-2	PUNCT
bjp-13842	70	9	α	α	DET
bjp-13842	70	10	sense	sense	NOUN
bjp-13842	70	11	:	:	PUNCT
bjp-13842	70	12	5	5	NUM
bjp-13842	70	13	’	'	PUNCT
bjp-13842	70	14	ccgtactgtcaacctcaagtc	ccgtactgtcaacctcaagtc	NOUN
bjp-13842	70	15	3	3	NUM
bjp-13842	70	16	’	'	PUNCT
bjp-13842	70	17	,	,	PUNCT
bjp-13842	70	18	antisense	antisense	NOUN
bjp-13842	70	19	:	:	PUNCT
bjp-13842	70	20	5	5	NUM
bjp-13842	70	21	’	'	PUNCT
bjp-13842	70	22	ccttgtagccacacagactatt	ccttgtagccacacagactatt	NOUN
bjp-13842	70	23	3	3	NUM
bjp-13842	70	24	’	'	PUNCT
bjp-13842	70	25	.	.	PUNCT
bjp-13842	71	1	epo	epo	PROPN
bjp-13842	71	2	sense	sense	NOUN
bjp-13842	71	3	:	:	PUNCT
bjp-13842	71	4	5	5	NUM
bjp-13842	71	5	’	'	PUNCT
bjp-13842	71	6	caaggaggccgagaatatcac3	caaggaggccgagaatatcac3	NOUN
bjp-13842	71	7	’	'	PUNCT
bjp-13842	71	8	,	,	PUNCT
bjp-13842	71	9	antisense	antisense	NOUN
bjp-13842	71	10	:	:	PUNCT
bjp-13842	71	11	5	5	NUM
bjp-13842	71	12	’	'	PUNCT
bjp-13842	71	13	catcctcttccaggcatagaaat	catcctcttccaggcatagaaat	NOUN
bjp-13842	71	14	3	3	NUM
bjp-13842	71	15	’	'	PUNCT
bjp-13842	71	16	.	.	PUNCT
bjp-13842	72	1	pai1	pai1	PROPN
bjp-13842	72	2	sense	sense	NOUN
bjp-13842	72	3	:	:	PUNCT
bjp-13842	72	4	5	5	NUM
bjp-13842	72	5	’	'	PUNCT
bjp-13842	72	6	agatcgaggtgaacgagagt3	agatcgaggtgaacgagagt3	ADJ
bjp-13842	72	7	’	'	PUNCT
bjp-13842	72	8	,	,	PUNCT
bjp-13842	72	9	antisense	antisense	NOUN
bjp-13842	72	10	:	:	PUNCT
bjp-13842	72	11	5	5	NUM
bjp-13842	72	12	’	'	PUNCT
bjp-13842	72	13	cacaaagaggaagggtctgtc3	cacaaagaggaagggtctgtc3	NOUN
bjp-13842	72	14	’	'	PUNCT
bjp-13842	72	15	,	,	PUNCT
bjp-13842	72	16	and	and	CCONJ
bjp-13842	72	17	beta	beta	NOUN
bjp-13842	72	18	-	-	PUNCT
bjp-13842	72	19	actin	actin	NOUN
bjp-13842	72	20	sense	sense	NOUN
bjp-13842	72	21	:	:	PUNCT
bjp-13842	72	22	5	5	NUM
bjp-13842	72	23	’	'	PUNCT
bjp-13842	72	24	acccagcacaatgaagatca	acccagcacaatgaagatca	NOUN
bjp-13842	72	25	3	3	NUM
bjp-13842	72	26	’	'	PUNCT
bjp-13842	72	27	,	,	PUNCT
bjp-13842	72	28	antisense	antisense	NOUN
bjp-13842	72	29	:	:	PUNCT
bjp-13842	72	30	5’cgatccacacggagtacttg3	5’cgatccacacggagtacttg3	NUM
bjp-13842	72	31	’	'	PUNCT
bjp-13842	72	32	.	.	PUNCT
bjp-13842	73	1	qpcr	qpcr	ADJ
bjp-13842	73	2	results	result	NOUN
bjp-13842	73	3	were	be	AUX
bjp-13842	73	4	normalized	normalize	VERB
bjp-13842	73	5	with	with	ADP
bjp-13842	73	6	beta	beta	NOUN
bjp-13842	73	7	-	-	PUNCT
bjp-13842	73	8	actin	actin	NOUN
bjp-13842	73	9	.	.	PUNCT
bjp-13842	74	1	results	result	NOUN
bjp-13842	74	2	are	be	AUX
bjp-13842	74	3	the	the	DET
bjp-13842	74	4	averages	average	NOUN
bjp-13842	74	5	of	of	ADP
bjp-13842	74	6	a	a	DET
bjp-13842	74	7	minimum	minimum	NOUN
bjp-13842	74	8	of	of	ADP
bjp-13842	74	9	three	three	NUM
bjp-13842	74	10	independent	independent	ADJ
bjp-13842	74	11	experiments	experiment	NOUN
bjp-13842	74	12	performed	perform	VERB
bjp-13842	74	13	in	in	ADP
bjp-13842	74	14	triplicate	triplicate	NOUN
bjp-13842	74	15	.	.	PUNCT
bjp-13842	75	1	tumor	tumor	NOUN
bjp-13842	75	2	xenograft	xenograft	PROPN
bjp-13842	75	3	in	in	ADP
bjp-13842	75	4	vivo	vivo	ADJ
bjp-13842	75	5	athymic	athymic	ADJ
bjp-13842	75	6	6	6	NUM
bjp-13842	75	7	-	-	SYM
bjp-13842	75	8	8	8	NUM
bjp-13842	75	9	week	week	NOUN
bjp-13842	75	10	-	-	PUNCT
bjp-13842	75	11	old	old	ADJ
bjp-13842	75	12	balb	balb	NOUN
bjp-13842	75	13	/	/	SYM
bjp-13842	75	14	c	c	NOUN
bjp-13842	75	15	nude	nude	ADJ
bjp-13842	75	16	mice	mouse	NOUN
bjp-13842	75	17	were	be	AUX
bjp-13842	75	18	purchased	purchase	VERB
bjp-13842	75	19	from	from	ADP
bjp-13842	75	20	the	the	DET
bjp-13842	75	21	animal	animal	NOUN
bjp-13842	75	22	center	center	NOUN
bjp-13842	75	23	of	of	ADP
bjp-13842	75	24	shanghai	shanghai	PROPN
bjp-13842	75	25	jiaotong	jiaotong	PROPN
bjp-13842	75	26	university	university	PROPN
bjp-13842	75	27	,	,	PUNCT
bjp-13842	75	28	china	china	PROPN
bjp-13842	75	29	.	.	PUNCT
bjp-13842	76	1	osteosarcoma	osteosarcoma	PROPN
bjp-13842	76	2	cell	cell	NOUN
bjp-13842	76	3	line	line	NOUN
bjp-13842	76	4	mg-63	mg-63	NOUN
bjp-13842	76	5	cells	cell	NOUN
bjp-13842	76	6	were	be	AUX
bjp-13842	76	7	trypsinized	trypsinize	VERB
bjp-13842	76	8	and	and	CCONJ
bjp-13842	76	9	washed	wash	VERB
bjp-13842	76	10	with	with	ADP
bjp-13842	76	11	pbs	pbs	PROPN
bjp-13842	76	12	.	.	PUNCT
bjp-13842	77	1	then	then	ADV
bjp-13842	77	2	,	,	PUNCT
bjp-13842	77	3	3	3	NUM
bjp-13842	77	4	×	×	NOUN
bjp-13842	77	5	106	106	NUM
bjp-13842	77	6	cells	cell	NOUN
bjp-13842	77	7	were	be	AUX
bjp-13842	77	8	re	re	VERB
bjp-13842	77	9	-	-	VERB
bjp-13842	77	10	suspended	suspend	VERB
bjp-13842	77	11	in	in	ADP
bjp-13842	77	12	200	200	NUM
bjp-13842	77	13	μlof	μlof	ADJ
bjp-13842	77	14	pbs	pbs	NOUN
bjp-13842	77	15	and	and	CCONJ
bjp-13842	77	16	injected	inject	VERB
bjp-13842	77	17	subcutaneously	subcutaneously	ADV
bjp-13842	77	18	at	at	ADP
bjp-13842	77	19	the	the	DET
bjp-13842	77	20	right	right	ADJ
bjp-13842	77	21	flank	flank	NOUN
bjp-13842	77	22	of	of	ADP
bjp-13842	77	23	nude	nude	ADJ
bjp-13842	77	24	mice	mouse	NOUN
bjp-13842	77	25	.	.	PUNCT
bjp-13842	78	1	one	one	NUM
bjp-13842	78	2	week	week	NOUN
bjp-13842	78	3	later	later	ADV
bjp-13842	78	4	,	,	PUNCT
bjp-13842	78	5	subcutaneous	subcutaneous	ADJ
bjp-13842	78	6	tumors	tumor	NOUN
bjp-13842	78	7	were	be	AUX
bjp-13842	78	8	macroscopic	macroscopic	ADJ
bjp-13842	78	9	visible	visible	ADJ
bjp-13842	78	10	.	.	PUNCT
bjp-13842	79	1	cancer	cancer	NOUN
bjp-13842	79	2	-	-	PUNCT
bjp-13842	79	3	bearing	bear	VERB
bjp-13842	79	4	mice	mouse	NOUN
bjp-13842	79	5	were	be	AUX
bjp-13842	79	6	randomly	randomly	ADV
bjp-13842	79	7	divided	divide	VERB
bjp-13842	79	8	into	into	ADP
bjp-13842	79	9	control	control	NOUN
bjp-13842	79	10	group	group	NOUN
bjp-13842	79	11	(	(	PUNCT
bjp-13842	79	12	n=6	n=6	NOUN
bjp-13842	79	13	)	)	PUNCT
bjp-13842	79	14	,	,	PUNCT
bjp-13842	79	15	tsa	tsa	NOUN
bjp-13842	79	16	group	group	NOUN
bjp-13842	79	17	(	(	PUNCT
bjp-13842	79	18	n=6	n=6	NOUN
bjp-13842	79	19	)	)	PUNCT
bjp-13842	79	20	and	and	CCONJ
bjp-13842	79	21	cyclophosphamide	cyclophosphamide	PROPN
bjp-13842	79	22	(	(	PUNCT
bjp-13842	79	23	ctx	ctx	NOUN
bjp-13842	79	24	)	)	PUNCT
bjp-13842	79	25	group	group	NOUN
bjp-13842	79	26	(	(	PUNCT
bjp-13842	79	27	n=6	n=6	NOUN
bjp-13842	79	28	)	)	PUNCT
bjp-13842	79	29	.	.	PUNCT
bjp-13842	80	1	ctx	ctx	PROPN
bjp-13842	80	2	served	serve	VERB
bjp-13842	80	3	as	as	ADP
bjp-13842	80	4	a	a	DET
bjp-13842	80	5	positive	positive	ADJ
bjp-13842	80	6	control	control	NOUN
bjp-13842	80	7	of	of	ADP
bjp-13842	80	8	anticancer	anticancer	NOUN
bjp-13842	80	9	agent	agent	NOUN
bjp-13842	80	10	.	.	PUNCT
bjp-13842	81	1	mice	mouse	NOUN
bjp-13842	81	2	in	in	ADP
bjp-13842	81	3	the	the	DET
bjp-13842	81	4	tsa	tsa	NOUN
bjp-13842	81	5	group	group	NOUN
bjp-13842	81	6	were	be	AUX
bjp-13842	81	7	treated	treat	VERB
bjp-13842	81	8	with	with	ADP
bjp-13842	81	9	tsa	tsa	NOUN
bjp-13842	81	10	at	at	ADP
bjp-13842	81	11	1	1	NUM
bjp-13842	81	12	mg	mg	PROPN
bjp-13842	81	13	/	/	SYM
bjp-13842	81	14	kg	kg	NOUN
bjp-13842	81	15	once	once	ADV
bjp-13842	81	16	biweekly	biweekly	ADV
bjp-13842	81	17	;	;	PUNCT
bjp-13842	81	18	mice	mouse	NOUN
bjp-13842	81	19	in	in	ADP
bjp-13842	81	20	the	the	DET
bjp-13842	81	21	ctx	ctx	NOUN
bjp-13842	81	22	group	group	NOUN
bjp-13842	81	23	were	be	AUX
bjp-13842	81	24	treated	treat	VERB
bjp-13842	81	25	with	with	ADP
bjp-13842	81	26	ctx	ctx	NOUN
bjp-13842	81	27	at	at	ADP
bjp-13842	81	28	20	20	NUM
bjp-13842	81	29	mg	mg	NOUN
bjp-13842	81	30	/	/	SYM
bjp-13842	81	31	kg	kg	NOUN
bjp-13842	81	32	once	once	ADV
bjp-13842	81	33	biweekly	biweekly	ADV
bjp-13842	81	34	;	;	PUNCT
bjp-13842	81	35	and	and	CCONJ
bjp-13842	81	36	mice	mouse	NOUN
bjp-13842	81	37	in	in	ADP
bjp-13842	81	38	the	the	DET
bjp-13842	81	39	control	control	NOUN
bjp-13842	81	40	group	group	NOUN
bjp-13842	81	41	were	be	AUX
bjp-13842	81	42	treated	treat	VERB
bjp-13842	81	43	with	with	ADP
bjp-13842	81	44	normal	normal	ADJ
bjp-13842	81	45	saline	saline	NOUN
bjp-13842	81	46	containing	contain	VERB
bjp-13842	81	47	5%dmso	5%dmso	NUM
bjp-13842	81	48	.	.	PUNCT
bjp-13842	82	1	mice	mouse	NOUN
bjp-13842	82	2	were	be	AUX
bjp-13842	82	3	treated	treat	VERB
bjp-13842	82	4	for	for	ADP
bjp-13842	82	5	17	17	NUM
bjp-13842	82	6	days	day	NOUN
bjp-13842	82	7	,	,	PUNCT
bjp-13842	82	8	tumor	tumor	NOUN
bjp-13842	82	9	size	size	NOUN
bjp-13842	82	10	was	be	AUX
bjp-13842	82	11	measured	measure	VERB
bjp-13842	82	12	with	with	ADP
bjp-13842	82	13	a	a	DET
bjp-13842	82	14	caliper	caliper	NOUN
bjp-13842	82	15	every	every	DET
bjp-13842	82	16	three	three	NUM
bjp-13842	82	17	days	day	NOUN
bjp-13842	82	18	,	,	PUNCT
bjp-13842	82	19	and	and	CCONJ
bjp-13842	82	20	the	the	DET
bjp-13842	82	21	tumor	tumor	NOUN
bjp-13842	82	22	volume	volume	NOUN
bjp-13842	82	23	calculated	calculate	VERB
bjp-13842	82	24	as	as	ADP
bjp-13842	82	25	v	v	NOUN
bjp-13842	82	26	=	=	NOUN
bjp-13842	82	27	w^2xl/2	w^2xl/2	NOUN
bjp-13842	82	28	.	.	PUNCT
bjp-13842	83	1	the	the	DET
bjp-13842	83	2	therapeutic	therapeutic	ADJ
bjp-13842	83	3	efficacy	efficacy	NOUN
bjp-13842	83	4	of	of	ADP
bjp-13842	83	5	tsa	tsa	PROPN
bjp-13842	83	6	and	and	CCONJ
bjp-13842	83	7	ctx	ctx	NOUN
bjp-13842	83	8	was	be	AUX
bjp-13842	83	9	assessed	assess	VERB
bjp-13842	83	10	by	by	ADP
bjp-13842	83	11	the	the	DET
bjp-13842	83	12	change	change	NOUN
bjp-13842	83	13	in	in	ADP
bjp-13842	83	14	tumor	tumor	NOUN
bjp-13842	83	15	volume	volume	NOUN
bjp-13842	83	16	.	.	PUNCT
bjp-13842	84	1	after	after	ADP
bjp-13842	84	2	the	the	DET
bjp-13842	84	3	treatment	treatment	NOUN
bjp-13842	84	4	,	,	PUNCT
bjp-13842	84	5	mice	mouse	NOUN
bjp-13842	84	6	were	be	AUX
bjp-13842	84	7	sacrificed	sacrifice	VERB
bjp-13842	84	8	and	and	CCONJ
bjp-13842	84	9	tumors	tumor	NOUN
bjp-13842	84	10	were	be	AUX
bjp-13842	84	11	harvested	harvest	VERB
bjp-13842	84	12	for	for	ADP
bjp-13842	84	13	western	western	ADJ
bjp-13842	84	14	blot	blot	NOUN
bjp-13842	84	15	assay	assay	VERB
bjp-13842	84	16	.	.	PUNCT
bjp-13842	85	1	statistical	statistical	ADJ
bjp-13842	85	2	analysis	analysis	NOUN
bjp-13842	85	3	comparisons	comparison	NOUN
bjp-13842	85	4	of	of	ADP
bjp-13842	85	5	unpaired	unpaired	ADJ
bjp-13842	85	6	data	datum	NOUN
bjp-13842	85	7	were	be	AUX
bjp-13842	85	8	done	do	VERB
bjp-13842	85	9	with	with	ADP
bjp-13842	85	10	student	student	NOUN
bjp-13842	85	11	’s	’s	PART
bjp-13842	85	12	t	t	PROPN
bjp-13842	85	13	-	-	PUNCT
bjp-13842	85	14	test	test	NOUN
bjp-13842	85	15	.	.	PUNCT
bjp-13842	86	1	a	a	DET
bjp-13842	86	2	value	value	NOUN
bjp-13842	86	3	of	of	ADP
bjp-13842	86	4	p<0.05	p<0.05	NOUN
bjp-13842	86	5	was	be	AUX
bjp-13842	86	6	considered	consider	VERB
bjp-13842	86	7	statistically	statistically	ADV
bjp-13842	86	8	significant	significant	ADJ
bjp-13842	86	9	.	.	PUNCT
bjp-13842	87	1	results	result	NOUN
bjp-13842	87	2	to	to	PART
bjp-13842	87	3	investigate	investigate	VERB
bjp-13842	87	4	the	the	DET
bjp-13842	87	5	effect	effect	NOUN
bjp-13842	87	6	of	of	ADP
bjp-13842	87	7	tsa	tsa	NOUN
bjp-13842	87	8	on	on	ADP
bjp-13842	87	9	hif-2α	hif-2α	ADJ
bjp-13842	87	10	protein	protein	NOUN
bjp-13842	87	11	expression	expression	NOUN
bjp-13842	87	12	,	,	PUNCT
bjp-13842	87	13	mg-63	mg-63	NOUN
bjp-13842	87	14	cells	cell	NOUN
bjp-13842	87	15	were	be	AUX
bjp-13842	87	16	treated	treat	VERB
bjp-13842	87	17	with	with	ADP
bjp-13842	87	18	tsa	tsa	NOUN
bjp-13842	87	19	at	at	ADP
bjp-13842	87	20	different	different	ADJ
bjp-13842	87	21	doses	dose	NOUN
bjp-13842	87	22	in	in	ADP
bjp-13842	87	23	hypoxia	hypoxia	NOUN
bjp-13842	87	24	(	(	PUNCT
bjp-13842	87	25	1	1	NUM
bjp-13842	87	26	%	%	NOUN
bjp-13842	87	27	o2	o2	PROPN
bjp-13842	87	28	)	)	PUNCT
bjp-13842	87	29	for	for	ADP
bjp-13842	87	30	8	8	NUM
bjp-13842	87	31	hours	hour	NOUN
bjp-13842	87	32	.	.	PUNCT
bjp-13842	88	1	as	as	SCONJ
bjp-13842	88	2	shown	show	VERB
bjp-13842	88	3	in	in	ADP
bjp-13842	88	4	figure	figure	NOUN
bjp-13842	88	5	1a	1a	NOUN
bjp-13842	88	6	,	,	PUNCT
bjp-13842	88	7	tsa	tsa	NOUN
bjp-13842	88	8	induced	induce	VERB
bjp-13842	88	9	a	a	DET
bjp-13842	88	10	dose	dose	NOUN
bjp-13842	88	11	-	-	PUNCT
bjp-13842	88	12	dependent	dependent	ADJ
bjp-13842	88	13	inhibition	inhibition	NOUN
bjp-13842	88	14	of	of	ADP
bjp-13842	88	15	hif-2α	hif-2α	ADJ
bjp-13842	88	16	protein	protein	NOUN
bjp-13842	88	17	expression	expression	NOUN
bjp-13842	88	18	.	.	PUNCT
bjp-13842	89	1	similar	similar	ADJ
bjp-13842	89	2	phenomena	phenomenon	NOUN
bjp-13842	89	3	were	be	AUX
bjp-13842	89	4	observed	observe	VERB
bjp-13842	89	5	in	in	ADP
bjp-13842	89	6	other	other	ADJ
bjp-13842	89	7	cell	cell	NOUN
bjp-13842	89	8	lines	line	NOUN
bjp-13842	89	9	(	(	PUNCT
bjp-13842	89	10	data	datum	NOUN
bjp-13842	89	11	not	not	PART
bjp-13842	89	12	shown	show	VERB
bjp-13842	89	13	)	)	PUNCT
bjp-13842	89	14	.	.	PUNCT
bjp-13842	90	1	tsa	tsa	NOUN
bjp-13842	90	2	did	do	AUX
bjp-13842	90	3	not	not	PART
bjp-13842	90	4	affect	affect	VERB
bjp-13842	90	5	the	the	DET
bjp-13842	90	6	hif-2α	hif-2α	ADJ
bjp-13842	90	7	mrna	mrna	NOUN
bjp-13842	90	8	expression	expression	NOUN
bjp-13842	90	9	but	but	CCONJ
bjp-13842	90	10	remarkably	remarkably	ADV
bjp-13842	90	11	inhibited	inhibit	VERB
bjp-13842	90	12	the	the	DET
bjp-13842	90	13	expression	expression	NOUN
bjp-13842	90	14	of	of	ADP
bjp-13842	90	15	hif-2α	hif-2α	ADJ
bjp-13842	90	16	specific	specific	ADJ
bjp-13842	90	17	target	target	NOUN
bjp-13842	90	18	genes	gene	NOUN
bjp-13842	90	19	such	such	ADJ
bjp-13842	90	20	as	as	ADP
bjp-13842	90	21	epo	epo	PROPN
bjp-13842	90	22	and	and	CCONJ
bjp-13842	90	23	pai1	pai1	PROPN
bjp-13842	90	24	(	(	PUNCT
bjp-13842	90	25	figure	figure	NOUN
bjp-13842	90	26	1b	1b	NUM
bjp-13842	90	27	)	)	PUNCT
bjp-13842	90	28	.	.	PUNCT
bjp-13842	91	1	to	to	PART
bjp-13842	91	2	rule	rule	VERB
bjp-13842	91	3	out	out	ADP
bjp-13842	91	4	the	the	DET
bjp-13842	91	5	effect	effect	NOUN
bjp-13842	91	6	of	of	ADP
bjp-13842	91	7	tsa	tsa	NOUN
bjp-13842	91	8	on	on	ADP
bjp-13842	91	9	hif-2α	hif-2α	NOUN
bjp-13842	91	10	translation	translation	NOUN
bjp-13842	91	11	,	,	PUNCT
bjp-13842	91	12	mg63	mg63	PROPN
bjp-13842	91	13	cells	cell	NOUN
bjp-13842	91	14	were	be	AUX
bjp-13842	91	15	treated	treat	VERB
bjp-13842	91	16	with	with	ADP
bjp-13842	91	17	mg132	mg132	PRON
bjp-13842	91	18	without	without	ADP
bjp-13842	91	19	or	or	CCONJ
bjp-13842	91	20	with	with	ADP
bjp-13842	91	21	tsa	tsa	NOUN
bjp-13842	91	22	(	(	PUNCT
bjp-13842	91	23	300	300	NUM
bjp-13842	91	24	nm	nm	NOUN
bjp-13842	91	25	)	)	PUNCT
bjp-13842	91	26	.	.	PUNCT
bjp-13842	92	1	results	result	NOUN
bjp-13842	92	2	showed	show	VERB
bjp-13842	92	3	that	that	SCONJ
bjp-13842	92	4	hif-2α	hif-2α	ADJ
bjp-13842	92	5	protein	protein	NOUN
bjp-13842	92	6	accumulation	accumulation	NOUN
bjp-13842	92	7	was	be	AUX
bjp-13842	92	8	not	not	PART
bjp-13842	92	9	affected	affect	VERB
bjp-13842	92	10	by	by	ADP
bjp-13842	92	11	tsa	tsa	NOUN
bjp-13842	92	12	.	.	PUNCT
bjp-13842	93	1	collectively	collectively	ADV
bjp-13842	93	2	,	,	PUNCT
bjp-13842	93	3	these	these	DET
bjp-13842	93	4	findings	finding	NOUN
bjp-13842	93	5	suggest	suggest	VERB
bjp-13842	93	6	that	that	SCONJ
bjp-13842	93	7	tsa	tsa	NOUN
bjp-13842	93	8	inhibits	inhibit	VERB
bjp-13842	93	9	hif-2α	hif-2α	ADJ
bjp-13842	93	10	protein	protein	NOUN
bjp-13842	93	11	expression	expression	NOUN
bjp-13842	93	12	via	via	ADP
bjp-13842	93	13	a	a	DET
bjp-13842	93	14	posttranslational	posttranslational	ADJ
bjp-13842	93	15	mechanism	mechanism	NOUN
bjp-13842	93	16	.	.	PUNCT
bjp-13842	94	1	to	to	PART
bjp-13842	94	2	examine	examine	VERB
bjp-13842	94	3	whether	whether	SCONJ
bjp-13842	94	4	tsa	tsa	NOUN
bjp-13842	94	5	-	-	PUNCT
bjp-13842	94	6	mediated	mediate	VERB
bjp-13842	94	7	hif-2α	hif-2α	NOUN
bjp-13842	94	8	degradation	degradation	NOUN
bjp-13842	94	9	is	be	AUX
bjp-13842	94	10	related	relate	VERB
bjp-13842	94	11	to	to	ADP
bjp-13842	94	12	proteasome	proteasome	NOUN
bjp-13842	94	13	,	,	PUNCT
bjp-13842	94	14	mg-63	mg-63	NOUN
bjp-13842	94	15	cells	cell	NOUN
bjp-13842	94	16	were	be	AUX
bjp-13842	94	17	treated	treat	VERB
bjp-13842	94	18	in	in	ADP
bjp-13842	94	19	hypoxia	hypoxia	NOUN
bjp-13842	94	20	for	for	ADP
bjp-13842	94	21	8	8	NUM
bjp-13842	94	22	hours	hour	NOUN
bjp-13842	94	23	with	with	ADP
bjp-13842	94	24	tsa	tsa	NOUN
bjp-13842	94	25	at	at	ADP
bjp-13842	94	26	different	different	ADJ
bjp-13842	94	27	concentrations	concentration	NOUN
bjp-13842	94	28	in	in	ADP
bjp-13842	94	29	the	the	DET
bjp-13842	94	30	absence	absence	NOUN
bjp-13842	94	31	or	or	CCONJ
bjp-13842	94	32	presence	presence	NOUN
bjp-13842	94	33	of	of	ADP
bjp-13842	94	34	5	5	NUM
bjp-13842	94	35	µm	µm	ADP
bjp-13842	94	36	proteasome	proteasome	NOUN
bjp-13842	94	37	inhibitor	inhibitor	NOUN
bjp-13842	94	38	mg132	mg132	PROPN
bjp-13842	94	39	.	.	PROPN
bjp-13842	94	40	as	as	SCONJ
bjp-13842	94	41	shown	show	VERB
bjp-13842	94	42	in	in	ADP
bjp-13842	94	43	figure	figure	NOUN
bjp-13842	94	44	2a	2a	NUM
bjp-13842	94	45	,	,	PUNCT
bjp-13842	94	46	mg132	mg132	PROPN
bjp-13842	94	47	completely	completely	ADV
bjp-13842	94	48	reversed	reverse	VERB
bjp-13842	94	49	the	the	DET
bjp-13842	94	50	effect	effect	NOUN
bjp-13842	94	51	of	of	ADP
bjp-13842	94	52	tsa	tsa	NOUN
bjp-13842	94	53	on	on	ADP
bjp-13842	94	54	hif-2α	hif-2α	NOUN
bjp-13842	94	55	,	,	PUNCT
bjp-13842	94	56	indicating	indicate	VERB
bjp-13842	94	57	that	that	SCONJ
bjp-13842	94	58	tsa	tsa	NOUN
bjp-13842	94	59	mediated	mediate	VERB
bjp-13842	94	60	hif-2α	hif-2α	NOUN
bjp-13842	94	61	degradation	degradation	NOUN
bjp-13842	94	62	was	be	AUX
bjp-13842	94	63	proteasome	proteasome	NOUN
bjp-13842	94	64	-	-	PUNCT
bjp-13842	94	65	dependent	dependent	ADJ
bjp-13842	94	66	.	.	PUNCT
bjp-13842	95	1	to	to	PART
bjp-13842	95	2	test	test	VERB
bjp-13842	95	3	the	the	DET
bjp-13842	95	4	role	role	NOUN
bjp-13842	95	5	of	of	ADP
bjp-13842	95	6	vhl	vhl	NOUN
bjp-13842	95	7	in	in	ADP
bjp-13842	95	8	the	the	DET
bjp-13842	95	9	tsa	tsa	NOUN
bjp-13842	95	10	induced	induce	VERB
bjp-13842	95	11	hif-2α	hif-2α	NOUN
bjp-13842	95	12	degradation	degradation	NOUN
bjp-13842	95	13	,	,	PUNCT
bjp-13842	95	14	vhl	vhl	PROPN
bjp-13842	95	15	deficient	deficient	ADJ
bjp-13842	95	16	cells	cell	NOUN
bjp-13842	95	17	(	(	PUNCT
bjp-13842	95	18	786	786	NUM
bjp-13842	95	19	-	-	SYM
bjp-13842	95	20	0	0	NUM
bjp-13842	95	21	cells	cell	NOUN
bjp-13842	95	22	)	)	PUNCT
bjp-13842	95	23	were	be	AUX
bjp-13842	95	24	treated	treat	VERB
bjp-13842	95	25	with	with	ADP
bjp-13842	95	26	tsa	tsa	NOUN
bjp-13842	95	27	without	without	ADP
bjp-13842	95	28	or	or	CCONJ
bjp-13842	95	29	with	with	ADP
bjp-13842	95	30	mg132	mg132	PROPN
bjp-13842	95	31	.	.	PROPN
bjp-13842	95	32	as	as	SCONJ
bjp-13842	95	33	shown	show	VERB
bjp-13842	95	34	in	in	ADP
bjp-13842	95	35	figure	figure	NOUN
bjp-13842	95	36	2b	2b	NOUN
bjp-13842	95	37	,	,	PUNCT
bjp-13842	95	38	tsa	tsa	NOUN
bjp-13842	95	39	inhibited	inhibit	VERB
bjp-13842	95	40	the	the	DET
bjp-13842	95	41	hif2α	hif2α	X
bjp-13842	95	42	expression	expression	NOUN
bjp-13842	95	43	in	in	ADP
bjp-13842	95	44	vhl	vhl	PROPN
bjp-13842	95	45	(	(	PUNCT
bjp-13842	95	46	-/-	-/-	PROPN
bjp-13842	95	47	)	)	PUNCT
bjp-13842	95	48	cells	cell	NOUN
bjp-13842	95	49	in	in	ADP
bjp-13842	95	50	a	a	DET
bjp-13842	95	51	dose	dose	NOUN
bjp-13842	95	52	-	-	PUNCT
bjp-13842	95	53	dependent	dependent	ADJ
bjp-13842	95	54	manner	manner	NOUN
bjp-13842	95	55	as	as	ADP
bjp-13842	95	56	in	in	ADP
bjp-13842	95	57	vhl	vhl	PROPN
bjp-13842	95	58	(	(	PUNCT
bjp-13842	95	59	+	+	ADJ
bjp-13842	95	60	/+	/+	ADJ
bjp-13842	95	61	)	)	PUNCT
bjp-13842	95	62	cells	cell	NOUN
bjp-13842	95	63	,	,	PUNCT
bjp-13842	95	64	and	and	CCONJ
bjp-13842	95	65	this	this	DET
bjp-13842	95	66	effect	effect	NOUN
bjp-13842	95	67	was	be	AUX
bjp-13842	95	68	also	also	ADV
bjp-13842	95	69	abolished	abolish	VERB
bjp-13842	95	70	by	by	ADP
bjp-13842	95	71	mg132	mg132	PROPN
bjp-13842	95	72	.	.	PUNCT
bjp-13842	96	1	these	these	DET
bjp-13842	96	2	findings	finding	NOUN
bjp-13842	96	3	suggest	suggest	VERB
bjp-13842	96	4	that	that	SCONJ
bjp-13842	96	5	the	the	DET
bjp-13842	96	6	degradation	degradation	NOUN
bjp-13842	96	7	is	be	AUX
bjp-13842	96	8	vhl	vhl	NOUN
bjp-13842	96	9	-	-	PUNCT
bjp-13842	96	10	independent	independent	ADJ
bjp-13842	96	11	.	.	PUNCT
bjp-13842	97	1	to	to	PART
bjp-13842	97	2	confirm	confirm	VERB
bjp-13842	97	3	this	this	DET
bjp-13842	97	4	observation	observation	NOUN
bjp-13842	97	5	further	far	ADV
bjp-13842	97	6	,	,	PUNCT
bjp-13842	97	7	mg-63	mg-63	NOUN
bjp-13842	97	8	cells	cell	NOUN
bjp-13842	97	9	were	be	AUX
bjp-13842	97	10	transfected	transfecte	VERB
bjp-13842	97	11	with	with	ADP
bjp-13842	97	12	flag	flag	NOUN
bjp-13842	97	13	-	-	PUNCT
bjp-13842	97	14	tagged	tag	VERB
bjp-13842	97	15	plasmids	plasmid	NOUN
bjp-13842	97	16	encoding	encode	VERB
bjp-13842	97	17	either	either	CCONJ
bjp-13842	97	18	full	full	ADJ
bjp-13842	97	19	-	-	PUNCT
bjp-13842	97	20	length	length	NOUN
bjp-13842	97	21	hif2α	hif2α	NOUN
bjp-13842	97	22	or	or	CCONJ
bjp-13842	97	23	hif-2α	hif-2α	NOUN
bjp-13842	97	24	mutant	mutant	NOUN
bjp-13842	97	25	(	(	PUNCT
bjp-13842	97	26	p405a	p405a	PROPN
bjp-13842	97	27	/	/	SYM
bjp-13842	97	28	p531a	p531a	PROPN
bjp-13842	97	29	)	)	PUNCT
bjp-13842	97	30	.	.	PUNCT
bjp-13842	98	1	as	as	SCONJ
bjp-13842	98	2	shown	show	VERB
bjp-13842	98	3	in	in	ADP
bjp-13842	98	4	figure	figure	NOUN
bjp-13842	98	5	2c	2c	NOUN
bjp-13842	98	6	,	,	PUNCT
bjp-13842	98	7	mutations	mutation	NOUN
bjp-13842	98	8	of	of	ADP
bjp-13842	98	9	two	two	NUM
bjp-13842	98	10	key	key	ADJ
bjp-13842	98	11	proline	proline	NOUN
bjp-13842	98	12	residues	residue	NOUN
bjp-13842	98	13	in	in	ADP
bjp-13842	98	14	odd	odd	ADJ
bjp-13842	98	15	affect	affect	VERB
bjp-13842	98	16	the	the	DET
bjp-13842	98	17	response	response	NOUN
bjp-13842	98	18	to	to	ADP
bjp-13842	98	19	tsa	tsa	NOUN
bjp-13842	98	20	.	.	PUNCT
bjp-13842	99	1	taken	take	VERB
bjp-13842	99	2	together	together	ADV
bjp-13842	99	3	,	,	PUNCT
bjp-13842	99	4	these	these	PRON
bjp-13842	99	5	did	do	AUX
bjp-13842	99	6	not	not	PART
bjp-13842	99	7	findings	finding	VERB
bjp-13842	99	8	indicate	indicate	VERB
bjp-13842	99	9	that	that	SCONJ
bjp-13842	99	10	tsa	tsa	NOUN
bjp-13842	99	11	-	-	PUNCT
bjp-13842	99	12	induced	induce	VERB
bjp-13842	99	13	hif-2α	hif-2α	NOUN
bjp-13842	99	14	degradation	degradation	NOUN
bjp-13842	99	15	is	be	AUX
bjp-13842	99	16	proteasome	proteasome	NOUN
bjp-13842	99	17	-	-	PUNCT
bjp-13842	99	18	dependent	dependent	ADJ
bjp-13842	99	19	,	,	PUNCT
bjp-13842	99	20	but	but	CCONJ
bjp-13842	99	21	independent	independent	ADJ
bjp-13842	99	22	of	of	ADP
bjp-13842	99	23	vhl	vhl	PROPN
bjp-13842	99	24	.	.	PUNCT
bjp-13842	100	1	to	to	PART
bjp-13842	100	2	evaluate	evaluate	VERB
bjp-13842	100	3	the	the	DET
bjp-13842	100	4	effect	effect	NOUN
bjp-13842	100	5	of	of	ADP
bjp-13842	100	6	tsa	tsa	NOUN
bjp-13842	100	7	on	on	ADP
bjp-13842	100	8	tumor	tumor	NOUN
bjp-13842	100	9	growth	growth	NOUN
bjp-13842	100	10	in	in	ADP
bjp-13842	100	11	vivo	vivo	NOUN
bjp-13842	100	12	,	,	PUNCT
bjp-13842	100	13	mg-63	mg-63	NOUN
bjp-13842	100	14	cells	cell	NOUN
bjp-13842	100	15	were	be	AUX
bjp-13842	100	16	injected	inject	VERB
bjp-13842	100	17	subcutaneously	subcutaneously	ADV
bjp-13842	100	18	into	into	ADP
bjp-13842	100	19	nude	nude	ADJ
bjp-13842	100	20	mice	mouse	NOUN
bjp-13842	100	21	to	to	PART
bjp-13842	100	22	prepare	prepare	VERB
bjp-13842	100	23	a	a	DET
bjp-13842	100	24	tumor	tumor	NOUN
bjp-13842	100	25	xenograft	xenograft	NOUN
bjp-13842	100	26	.	.	PUNCT
bjp-13842	101	1	one	one	NUM
bjp-13842	101	2	week	week	NOUN
bjp-13842	101	3	later	later	ADV
bjp-13842	101	4	,	,	PUNCT
bjp-13842	101	5	mice	mouse	NOUN
bjp-13842	101	6	were	be	AUX
bjp-13842	101	7	randomly	randomly	ADV
bjp-13842	101	8	divided	divide	VERB
bjp-13842	101	9	into	into	ADP
bjp-13842	101	10	control	control	NOUN
bjp-13842	101	11	,	,	PUNCT
bjp-13842	101	12	tsa	tsa	NOUN
bjp-13842	101	13	and	and	CCONJ
bjp-13842	101	14	ctx	ctx	NOUN
bjp-13842	101	15	group	group	NOUN
bjp-13842	101	16	,	,	PUNCT
bjp-13842	101	17	in	in	ADP
bjp-13842	101	18	which	which	PRON
bjp-13842	101	19	mice	mouse	NOUN
bjp-13842	101	20	were	be	AUX
bjp-13842	101	21	treated	treat	VERB
bjp-13842	101	22	with	with	ADP
bjp-13842	101	23	normal	normal	ADJ
bjp-13842	101	24	saline	saline	NOUN
bjp-13842	101	25	,	,	PUNCT
bjp-13842	101	26	tsa	tsa	NOUN
bjp-13842	101	27	and	and	CCONJ
bjp-13842	101	28	ctx	ctx	NOUN
bjp-13842	101	29	,	,	PUNCT
bjp-13842	101	30	respectively	respectively	ADV
bjp-13842	101	31	.	.	PUNCT
bjp-13842	102	1	tumor	tumor	NOUN
bjp-13842	102	2	growth	growth	NOUN
bjp-13842	102	3	curve	curve	NOUN
bjp-13842	102	4	(	(	PUNCT
bjp-13842	102	5	figure	figure	NOUN
bjp-13842	102	6	3a	3a	NUM
bjp-13842	102	7	)	)	PUNCT
bjp-13842	102	8	showed	show	VERB
bjp-13842	102	9	that	that	SCONJ
bjp-13842	102	10	tsa	tsa	NOUN
bjp-13842	102	11	and	and	CCONJ
bjp-13842	102	12	ctx	ctx	NOUN
bjp-13842	102	13	significantly	significantly	ADV
bjp-13842	102	14	inhibited	inhibit	VERB
bjp-13842	102	15	the	the	DET
bjp-13842	102	16	tumor	tumor	NOUN
bjp-13842	102	17	growth	growth	NOUN
bjp-13842	102	18	(	(	PUNCT
bjp-13842	102	19	p=0.02	p=0.02	NOUN
bjp-13842	102	20	)	)	PUNCT
bjp-13842	102	21	.	.	PUNCT
bjp-13842	103	1	no	no	DET
bjp-13842	103	2	significant	significant	ADJ
bjp-13842	103	3	difference	difference	NOUN
bjp-13842	103	4	in	in	ADP
bjp-13842	103	5	body	body	NOUN
bjp-13842	103	6	weight	weight	NOUN
bjp-13842	103	7	was	be	AUX
bjp-13842	103	8	noticed	notice	VERB
bjp-13842	103	9	between	between	ADP
bjp-13842	103	10	tsa	tsa	PROPN
bjp-13842	103	11	group	group	NOUN
bjp-13842	103	12	and	and	CCONJ
bjp-13842	103	13	control	control	NOUN
bjp-13842	103	14	group	group	NOUN
bjp-13842	103	15	,	,	PUNCT
bjp-13842	103	16	and	and	CCONJ
bjp-13842	103	17	the	the	DET
bjp-13842	103	18	toxic	toxic	ADJ
bjp-13842	103	19	effects	effect	NOUN
bjp-13842	103	20	were	be	AUX
bjp-13842	103	21	not	not	PART
bjp-13842	103	22	observed	observe	VERB
bjp-13842	103	23	in	in	ADP
bjp-13842	103	24	both	both	DET
bjp-13842	103	25	groups	group	NOUN
bjp-13842	103	26	.	.	PUNCT
bjp-13842	104	1	however	however	ADV
bjp-13842	104	2	,	,	PUNCT
bjp-13842	104	3	in	in	ADP
bjp-13842	104	4	the	the	DET
bjp-13842	104	5	ctx	ctx	NOUN
bjp-13842	104	6	group	group	NOUN
bjp-13842	104	7	,	,	PUNCT
bjp-13842	104	8	the	the	DET
bjp-13842	104	9	body	body	NOUN
bjp-13842	104	10	weight	weight	NOUN
bjp-13842	104	11	was	be	AUX
bjp-13842	104	12	significantly	significantly	ADV
bjp-13842	104	13	lower	low	ADJ
bjp-13842	104	14	than	than	ADP
bjp-13842	104	15	that	that	PRON
bjp-13842	104	16	in	in	ADP
bjp-13842	104	17	the	the	DET
bjp-13842	104	18	control	control	NOUN
bjp-13842	104	19	group	group	NOUN
bjp-13842	104	20	(	(	PUNCT
bjp-13842	104	21	data	datum	NOUN
bjp-13842	104	22	not	not	PART
bjp-13842	104	23	shown	show	VERB
bjp-13842	104	24	)	)	PUNCT
bjp-13842	104	25	.	.	PUNCT
bjp-13842	105	1	to	to	PART
bjp-13842	105	2	assess	assess	VERB
bjp-13842	105	3	if	if	SCONJ
bjp-13842	105	4	the	the	PRON
bjp-13842	105	5	in	in	ADP
bjp-13842	105	6	vivo	vivo	ADJ
bjp-13842	105	7	inhibitory	inhibitory	ADJ
bjp-13842	105	8	effect	effect	NOUN
bjp-13842	105	9	of	of	ADP
bjp-13842	105	10	tsa	tsa	NOUN
bjp-13842	105	11	is	be	AUX
bjp-13842	105	12	related	relate	VERB
bjp-13842	105	13	to	to	ADP
bjp-13842	105	14	its	its	PRON
bjp-13842	105	15	effect	effect	NOUN
bjp-13842	105	16	on	on	ADP
bjp-13842	105	17	hif-2α	hif-2α	PROPN
bjp-13842	105	18	,	,	PUNCT
bjp-13842	105	19	the	the	DET
bjp-13842	105	20	hif-2α	hif-2α	ADJ
bjp-13842	105	21	protein	protein	NOUN
bjp-13842	105	22	expression	expression	NOUN
bjp-13842	105	23	was	be	AUX
bjp-13842	105	24	measured	measure	VERB
bjp-13842	105	25	in	in	ADP
bjp-13842	105	26	tumor	tumor	NOUN
bjp-13842	105	27	xenografts	xenograft	NOUN
bjp-13842	105	28	.	.	PUNCT
bjp-13842	106	1	western	western	ADJ
bjp-13842	106	2	blot	blot	NOUN
bjp-13842	106	3	assay	assay	VERB
bjp-13842	106	4	144	144	NUM
bjp-13842	106	5	bangladesh	bangladesh	PROPN
bjp-13842	106	6	j	j	PROPN
bjp-13842	106	7	pharmacol	pharmacol	PROPN
bjp-13842	106	8	2013	2013	NUM
bjp-13842	106	9	;	;	PUNCT
bjp-13842	106	10	8	8	NUM
bjp-13842	106	11	:	:	SYM
bjp-13842	106	12	142	142	NUM
bjp-13842	106	13	-	-	SYM
bjp-13842	106	14	148	148	NUM
bjp-13842	106	15	showed	show	VERB
bjp-13842	106	16	that	that	SCONJ
bjp-13842	106	17	tsa	tsa	NOUN
bjp-13842	106	18	remarkably	remarkably	ADV
bjp-13842	106	19	inhibited	inhibit	VERB
bjp-13842	106	20	the	the	DET
bjp-13842	106	21	hif-2α	hif-2α	ADJ
bjp-13842	106	22	expression	expression	NOUN
bjp-13842	106	23	in	in	ADP
bjp-13842	106	24	vivo	vivo	NOUN
bjp-13842	106	25	(	(	PUNCT
bjp-13842	106	26	figure	figure	NOUN
bjp-13842	106	27	3b	3b	NUM
bjp-13842	106	28	)	)	PUNCT
bjp-13842	106	29	,	,	PUNCT
bjp-13842	106	30	implying	imply	VERB
bjp-13842	106	31	that	that	SCONJ
bjp-13842	106	32	the	the	DET
bjp-13842	106	33	antitumor	antitumor	PROPN
bjp-13842	106	34	effect	effect	NOUN
bjp-13842	106	35	of	of	ADP
bjp-13842	106	36	tsa	tsa	NOUN
bjp-13842	106	37	is	be	AUX
bjp-13842	106	38	at	at	ADV
bjp-13842	106	39	least	least	ADV
bjp-13842	106	40	partially	partially	ADV
bjp-13842	106	41	mediated	mediate	VERB
bjp-13842	106	42	by	by	ADP
bjp-13842	106	43	its	its	PRON
bjp-13842	106	44	suppression	suppression	NOUN
bjp-13842	106	45	on	on	ADP
bjp-13842	106	46	hif-2α	hif-2α	NOUN
bjp-13842	106	47	expression	expression	NOUN
bjp-13842	106	48	.	.	PUNCT
bjp-13842	107	1	class	class	NOUN
bjp-13842	107	2	ii	ii	PROPN
bjp-13842	107	3	histone	histone	NOUN
bjp-13842	107	4	deacetylases	deacetylase	NOUN
bjp-13842	107	5	hdac4	hdac4	PROPN
bjp-13842	107	6	,	,	PUNCT
bjp-13842	107	7	hdac6	hdac6	PROPN
bjp-13842	107	8	and	and	CCONJ
bjp-13842	107	9	hdac7	hdac7	PROPN
bjp-13842	107	10	have	have	AUX
bjp-13842	107	11	been	be	AUX
bjp-13842	107	12	reported	report	VERB
bjp-13842	107	13	to	to	PART
bjp-13842	107	14	be	be	AUX
bjp-13842	107	15	implicated	implicate	VERB
bjp-13842	107	16	in	in	ADP
bjp-13842	107	17	the	the	DET
bjp-13842	107	18	regulation	regulation	NOUN
bjp-13842	107	19	of	of	ADP
bjp-13842	107	20	hif-1α	hif-1α	NOUN
bjp-13842	107	21	stability	stability	NOUN
bjp-13842	107	22	(	(	PUNCT
bjp-13842	108	1	qian	qian	PROPN
bjp-13842	108	2	et	et	PROPN
bjp-13842	108	3	al	al	PROPN
bjp-13842	108	4	.	.	PROPN
bjp-13842	108	5	,	,	PUNCT
bjp-13842	108	6	2006	2006	NUM
bjp-13842	108	7	;	;	PUNCT
bjp-13842	108	8	kong	kong	PROPN
bjp-13842	108	9	et	et	PROPN
bjp-13842	108	10	al	al	PROPN
bjp-13842	108	11	.	.	PROPN
bjp-13842	108	12	,	,	PUNCT
bjp-13842	108	13	2006	2006	NUM
bjp-13842	108	14	)	)	PUNCT
bjp-13842	108	15	.	.	PUNCT
bjp-13842	109	1	thus	thus	ADV
bjp-13842	109	2	,	,	PUNCT
bjp-13842	109	3	we	we	PRON
bjp-13842	109	4	hypothesized	hypothesize	VERB
bjp-13842	109	5	that	that	SCONJ
bjp-13842	109	6	class	class	NOUN
bjp-13842	109	7	ii	ii	PROPN
bjp-13842	109	8	hdacs	hdac	NOUN
bjp-13842	109	9	may	may	AUX
bjp-13842	109	10	involve	involve	VERB
bjp-13842	109	11	in	in	ADP
bjp-13842	109	12	the	the	DET
bjp-13842	109	13	regulation	regulation	NOUN
bjp-13842	109	14	of	of	ADP
bjp-13842	109	15	hif-2α	hif-2α	NOUN
bjp-13842	109	16	.	.	PUNCT
bjp-13842	110	1	to	to	PART
bjp-13842	110	2	test	test	VERB
bjp-13842	110	3	this	this	DET
bjp-13842	110	4	hypothesis	hypothesis	NOUN
bjp-13842	110	5	,	,	PUNCT
bjp-13842	110	6	the	the	DET
bjp-13842	110	7	expression	expression	NOUN
bjp-13842	110	8	of	of	ADP
bjp-13842	110	9	hdac4	hdac4	PROPN
bjp-13842	110	10	,	,	PUNCT
bjp-13842	110	11	hdac6	hdac6	PROPN
bjp-13842	110	12	and	and	CCONJ
bjp-13842	110	13	hdac7	hdac7	PROPN
bjp-13842	110	14	was	be	AUX
bjp-13842	110	15	down	down	ADV
bjp-13842	110	16	-	-	PUNCT
bjp-13842	110	17	regulated	regulate	VERB
bjp-13842	110	18	by	by	ADP
bjp-13842	110	19	rna	rna	NOUN
bjp-13842	110	20	interfering	interfering	NOUN
bjp-13842	110	21	.	.	PUNCT
bjp-13842	111	1	results	result	NOUN
bjp-13842	111	2	showed	show	VERB
bjp-13842	111	3	that	that	SCONJ
bjp-13842	111	4	silencing	silence	VERB
bjp-13842	111	5	of	of	ADP
bjp-13842	111	6	hdac6	hdac6	PROPN
bjp-13842	111	7	decreased	decrease	VERB
bjp-13842	111	8	the	the	DET
bjp-13842	111	9	hif-2α	hif-2α	ADJ
bjp-13842	111	10	protein	protein	NOUN
bjp-13842	111	11	expression	expression	NOUN
bjp-13842	111	12	in	in	ADP
bjp-13842	111	13	mg-63	mg-63	NOUN
bjp-13842	111	14	cells	cell	NOUN
bjp-13842	111	15	(	(	PUNCT
bjp-13842	111	16	figure	figure	NOUN
bjp-13842	111	17	4a	4a	NUM
bjp-13842	111	18	)	)	PUNCT
bjp-13842	111	19	.	.	PUNCT
bjp-13842	112	1	however	however	ADV
bjp-13842	112	2	,	,	PUNCT
bjp-13842	112	3	the	the	DET
bjp-13842	112	4	hif-2α	hif-2α	ADJ
bjp-13842	112	5	protein	protein	NOUN
bjp-13842	112	6	expression	expression	NOUN
bjp-13842	112	7	was	be	AUX
bjp-13842	112	8	not	not	PART
bjp-13842	112	9	affected	affect	VERB
bjp-13842	112	10	by	by	ADP
bjp-13842	112	11	silencing	silence	VERB
bjp-13842	112	12	of	of	ADP
bjp-13842	112	13	hdac4	hdac4	NOUN
bjp-13842	112	14	or	or	CCONJ
bjp-13842	112	15	hdac7	hdac7	X
bjp-13842	112	16	(	(	PUNCT
bjp-13842	112	17	data	datum	NOUN
bjp-13842	112	18	not	not	PART
bjp-13842	112	19	shown	show	VERB
bjp-13842	112	20	)	)	PUNCT
bjp-13842	112	21	.	.	PUNCT
bjp-13842	113	1	these	these	DET
bjp-13842	113	2	findings	finding	NOUN
bjp-13842	113	3	suggest	suggest	VERB
bjp-13842	113	4	that	that	SCONJ
bjp-13842	113	5	hdac6	hdac6	PROPN
bjp-13842	113	6	is	be	AUX
bjp-13842	113	7	likely	likely	ADJ
bjp-13842	113	8	to	to	PART
bjp-13842	113	9	be	be	AUX
bjp-13842	113	10	involved	involve	VERB
bjp-13842	113	11	in	in	ADP
bjp-13842	113	12	the	the	DET
bjp-13842	113	13	hif-2α	hif-2α	ADJ
bjp-13842	113	14	protein	protein	NOUN
bjp-13842	113	15	stability	stability	NOUN
bjp-13842	113	16	.	.	PUNCT
bjp-13842	114	1	to	to	PART
bjp-13842	114	2	explore	explore	VERB
bjp-13842	114	3	the	the	DET
bjp-13842	114	4	physical	physical	ADJ
bjp-13842	114	5	interaction	interaction	NOUN
bjp-13842	114	6	between	between	ADP
bjp-13842	114	7	hif-2α	hif-2α	PROPN
bjp-13842	114	8	and	and	CCONJ
bjp-13842	114	9	hdac6	hdac6	PROPN
bjp-13842	114	10	,	,	PUNCT
bjp-13842	114	11	immunoprecipitation	immunoprecipitation	NOUN
bjp-13842	114	12	of	of	ADP
bjp-13842	114	13	hdac6	hdac6	PROPN
bjp-13842	114	14	was	be	AUX
bjp-13842	114	15	done	do	VERB
bjp-13842	114	16	with	with	ADP
bjp-13842	114	17	hdac6	hdac6	NOUN
bjp-13842	114	18	antibody	antibody	NOUN
bjp-13842	114	19	.	.	PUNCT
bjp-13842	115	1	the	the	DET
bjp-13842	115	2	precipitated	precipitate	VERB
bjp-13842	115	3	complexes	complex	NOUN
bjp-13842	115	4	were	be	AUX
bjp-13842	115	5	immunoblotted	immunoblotte	VERB
bjp-13842	115	6	for	for	ADP
bjp-13842	115	7	hif-2α	hif-2α	NOUN
bjp-13842	115	8	.	.	PUNCT
bjp-13842	116	1	as	as	SCONJ
bjp-13842	116	2	shown	show	VERB
bjp-13842	116	3	in	in	ADP
bjp-13842	116	4	figure	figure	NOUN
bjp-13842	116	5	4b	4b	PROPN
bjp-13842	116	6	,	,	PUNCT
bjp-13842	116	7	hif	hif	PROPN
bjp-13842	116	8	-2α	-2α	PROPN
bjp-13842	116	9	was	be	AUX
bjp-13842	116	10	detectable	detectable	ADJ
bjp-13842	116	11	in	in	ADP
bjp-13842	116	12	the	the	DET
bjp-13842	116	13	precipitated	precipitate	VERB
bjp-13842	116	14	complexes	complex	NOUN
bjp-13842	116	15	,	,	PUNCT
bjp-13842	116	16	confirming	confirm	VERB
bjp-13842	116	17	that	that	SCONJ
bjp-13842	116	18	hif-2α	hif-2α	NOUN
bjp-13842	116	19	can	can	AUX
bjp-13842	116	20	physically	physically	ADV
bjp-13842	116	21	interact	interact	VERB
bjp-13842	116	22	with	with	ADP
bjp-13842	116	23	hdac6	hdac6	PROPN
bjp-13842	116	24	.	.	PUNCT
bjp-13842	117	1	in	in	ADP
bjp-13842	117	2	addition	addition	NOUN
bjp-13842	117	3	,	,	PUNCT
bjp-13842	117	4	we	we	PRON
bjp-13842	117	5	investigated	investigate	VERB
bjp-13842	117	6	if	if	SCONJ
bjp-13842	117	7	tsa	tsa	NOUN
bjp-13842	117	8	directly	directly	ADV
bjp-13842	117	9	acetylates	acetylate	VERB
bjp-13842	117	10	hif-2α	hif-2α	PROPN
bjp-13842	117	11	.	.	PUNCT
bjp-13842	118	1	mg-63	mg-63	NOUN
bjp-13842	118	2	cells	cell	NOUN
bjp-13842	118	3	were	be	AUX
bjp-13842	118	4	treated	treat	VERB
bjp-13842	118	5	with	with	ADP
bjp-13842	118	6	proteasome	proteasome	NOUN
bjp-13842	118	7	inhibitor	inhibitor	NOUN
bjp-13842	118	8	mg132	mg132	PROPN
bjp-13842	118	9	in	in	ADP
bjp-13842	118	10	hypoxia	hypoxia	NOUN
bjp-13842	118	11	for	for	ADP
bjp-13842	118	12	6	6	NUM
bjp-13842	118	13	h	h	NOUN
bjp-13842	118	14	with	with	ADP
bjp-13842	118	15	or	or	CCONJ
bjp-13842	118	16	without	without	ADP
bjp-13842	118	17	600	600	NUM
bjp-13842	118	18	nm	nm	NOUN
bjp-13842	118	19	tsa	tsa	NOUN
bjp-13842	118	20	.	.	PUNCT
bjp-13842	119	1	results	result	NOUN
bjp-13842	119	2	showed	show	VERB
bjp-13842	119	3	mg132	mg132	PRON
bjp-13842	119	4	prevented	prevent	VERB
bjp-13842	119	5	the	the	DET
bjp-13842	119	6	tsamediated	tsamediated	ADJ
bjp-13842	119	7	hif-2α	hif-2α	NOUN
bjp-13842	119	8	degradation	degradation	NOUN
bjp-13842	119	9	.	.	PUNCT
bjp-13842	120	1	cell	cell	NOUN
bjp-13842	120	2	lysates	lysate	NOUN
bjp-13842	120	3	were	be	AUX
bjp-13842	120	4	immunoprecipitated	immunoprecipitate	VERB
bjp-13842	120	5	with	with	ADP
bjp-13842	120	6	hif-2α	hif-2α	ADJ
bjp-13842	120	7	antibody	antibody	NOUN
bjp-13842	120	8	.	.	PUNCT
bjp-13842	121	1	as	as	SCONJ
bjp-13842	121	2	shown	show	VERB
bjp-13842	121	3	in	in	ADP
bjp-13842	121	4	figure	figure	NOUN
bjp-13842	121	5	4c	4c	NOUN
bjp-13842	121	6	,	,	PUNCT
bjp-13842	121	7	the	the	DET
bjp-13842	121	8	acetylated	acetylated	ADJ
bjp-13842	121	9	lysine	lysine	NOUN
bjp-13842	121	10	was	be	AUX
bjp-13842	121	11	detected	detect	VERB
bjp-13842	121	12	in	in	ADP
bjp-13842	121	13	the	the	DET
bjp-13842	121	14	immunoprecipitated	immunoprecipitated	ADJ
bjp-13842	121	15	hif-2α	hif-2α	PROPN
bjp-13842	121	16	after	after	ADP
bjp-13842	121	17	tsa	tsa	NOUN
bjp-13842	121	18	treatment	treatment	NOUN
bjp-13842	121	19	,	,	PUNCT
bjp-13842	121	20	indicating	indicate	VERB
bjp-13842	121	21	that	that	SCONJ
bjp-13842	121	22	tsa	tsa	NOUN
bjp-13842	121	23	directly	directly	ADV
bjp-13842	121	24	acetylates	acetylate	VERB
bjp-13842	121	25	hif-2α	hif-2α	PROPN
bjp-13842	121	26	.	.	PUNCT
bjp-13842	122	1	bangladesh	bangladesh	PROPN
bjp-13842	122	2	j	j	PROPN
bjp-13842	122	3	pharmacol	pharmacol	PROPN
bjp-13842	122	4	2013	2013	NUM
bjp-13842	122	5	;	;	PUNCT
bjp-13842	122	6	8	8	NUM
bjp-13842	122	7	:	:	SYM
bjp-13842	122	8	142	142	NUM
bjp-13842	122	9	-	-	SYM
bjp-13842	122	10	148	148	NUM
bjp-13842	122	11	145	145	NUM
bjp-13842	122	12	figure	figure	NOUN
bjp-13842	122	13	1	1	NUM
bjp-13842	122	14	:	:	PUNCT
bjp-13842	122	15	effect	effect	NOUN
bjp-13842	122	16	of	of	ADP
bjp-13842	122	17	tsa	tsa	NOUN
bjp-13842	122	18	on	on	ADP
bjp-13842	122	19	protein	protein	NOUN
bjp-13842	122	20	and	and	CCONJ
bjp-13842	122	21	mrna	mrna	NOUN
bjp-13842	122	22	expression	expression	NOUN
bjp-13842	122	23	of	of	ADP
bjp-13842	122	24	hif-2α	hif-2α	NOUN
bjp-13842	122	25	(	(	PUNCT
bjp-13842	122	26	a	a	PRON
bjp-13842	122	27	)	)	PUNCT
bjp-13842	122	28	mg-63	mg-63	NOUN
bjp-13842	122	29	cells	cell	NOUN
bjp-13842	122	30	were	be	AUX
bjp-13842	122	31	exposed	expose	VERB
bjp-13842	122	32	to	to	ADP
bjp-13842	122	33	1	1	NUM
bjp-13842	122	34	%	%	NOUN
bjp-13842	122	35	oxygen	oxygen	NOUN
bjp-13842	122	36	in	in	ADP
bjp-13842	122	37	the	the	DET
bjp-13842	122	38	presence	presence	NOUN
bjp-13842	122	39	of	of	ADP
bjp-13842	122	40	tsa	tsa	NOUN
bjp-13842	122	41	at	at	ADP
bjp-13842	122	42	different	different	ADJ
bjp-13842	122	43	concentrations	concentration	NOUN
bjp-13842	122	44	for	for	ADP
bjp-13842	122	45	8	8	NUM
bjp-13842	122	46	hours	hour	NOUN
bjp-13842	122	47	,	,	PUNCT
bjp-13842	122	48	and	and	CCONJ
bjp-13842	122	49	cell	cell	NOUN
bjp-13842	122	50	extracts	extract	NOUN
bjp-13842	122	51	were	be	AUX
bjp-13842	122	52	subjected	subject	VERB
bjp-13842	122	53	to	to	ADP
bjp-13842	122	54	sdspage	sdspage	NOUN
bjp-13842	122	55	followed	follow	VERB
bjp-13842	122	56	by	by	ADP
bjp-13842	122	57	immunoblotting	immunoblotte	VERB
bjp-13842	122	58	.	.	PUNCT
bjp-13842	123	1	(	(	PUNCT
bjp-13842	123	2	b	b	X
bjp-13842	123	3	)	)	PUNCT
bjp-13842	123	4	vhl	vhl	PROPN
bjp-13842	123	5	deficient	deficient	ADJ
bjp-13842	123	6	(	(	PUNCT
bjp-13842	123	7	-/-	-/-	PROPN
bjp-13842	123	8	)	)	PUNCT
bjp-13842	123	9	786	786	NUM
bjp-13842	123	10	-	-	SYM
bjp-13842	123	11	0	0	NUM
bjp-13842	123	12	cells	cell	NOUN
bjp-13842	123	13	were	be	AUX
bjp-13842	123	14	treated	treat	VERB
bjp-13842	123	15	with	with	ADP
bjp-13842	123	16	tsa	tsa	NOUN
bjp-13842	123	17	at	at	ADP
bjp-13842	123	18	different	different	ADJ
bjp-13842	123	19	concentrations	concentration	NOUN
bjp-13842	123	20	for	for	ADP
bjp-13842	123	21	16	16	NUM
bjp-13842	123	22	hours	hour	NOUN
bjp-13842	123	23	in	in	ADP
bjp-13842	123	24	normoxia	normoxia	PROPN
bjp-13842	123	25	,	,	PUNCT
bjp-13842	123	26	total	total	ADJ
bjp-13842	123	27	rna	rna	NOUN
bjp-13842	123	28	was	be	AUX
bjp-13842	123	29	isolated	isolate	VERB
bjp-13842	123	30	and	and	CCONJ
bjp-13842	123	31	qrt	qrt	NOUN
bjp-13842	123	32	-	-	PUNCT
bjp-13842	123	33	pcr	pcr	NOUN
bjp-13842	123	34	was	be	AUX
bjp-13842	123	35	performed	perform	VERB
bjp-13842	123	36	to	to	PART
bjp-13842	123	37	detect	detect	VERB
bjp-13842	123	38	the	the	DET
bjp-13842	123	39	relative	relative	ADJ
bjp-13842	123	40	mrna	mrna	NOUN
bjp-13842	123	41	expression	expression	NOUN
bjp-13842	123	42	levels	level	NOUN
bjp-13842	123	43	of	of	ADP
bjp-13842	123	44	hif-2α	hif-2α	NOUN
bjp-13842	123	45	,	,	PUNCT
bjp-13842	123	46	hif-2α	hif-2α	ADJ
bjp-13842	123	47	specific	specific	ADJ
bjp-13842	123	48	target	target	NOUN
bjp-13842	123	49	genes	gene	NOUN
bjp-13842	123	50	epo	epo	NOUN
bjp-13842	123	51	and	and	CCONJ
bjp-13842	123	52	pai1	pai1	PROPN
bjp-13842	123	53	discussion	discussion	NOUN
bjp-13842	123	54	hdacs	hdac	NOUN
bjp-13842	123	55	are	be	AUX
bjp-13842	123	56	a	a	DET
bjp-13842	123	57	large	large	ADJ
bjp-13842	123	58	family	family	NOUN
bjp-13842	123	59	of	of	ADP
bjp-13842	123	60	enzymes	enzyme	NOUN
bjp-13842	123	61	which	which	PRON
bjp-13842	123	62	can	can	AUX
bjp-13842	123	63	remove	remove	VERB
bjp-13842	123	64	the	the	DET
bjp-13842	123	65	acetyl	acetyl	NOUN
bjp-13842	123	66	group	group	NOUN
bjp-13842	123	67	from	from	ADP
bjp-13842	123	68	the	the	DET
bjp-13842	123	69	n	n	CCONJ
bjp-13842	123	70	-	-	PUNCT
bjp-13842	123	71	ε	ε	NOUN
bjp-13842	123	72	-	-	PUNCT
bjp-13842	123	73	lysines	lysine	NOUN
bjp-13842	123	74	of	of	ADP
bjp-13842	123	75	histones	histone	NOUN
bjp-13842	123	76	.	.	PUNCT
bjp-13842	124	1	to	to	ADP
bjp-13842	124	2	date	date	NOUN
bjp-13842	124	3	,	,	PUNCT
bjp-13842	124	4	18	18	NUM
bjp-13842	124	5	human	human	ADJ
bjp-13842	124	6	hdac	hdac	NOUN
bjp-13842	124	7	have	have	AUX
bjp-13842	124	8	been	be	AUX
bjp-13842	124	9	identified	identify	VERB
bjp-13842	124	10	and	and	CCONJ
bjp-13842	124	11	can	can	AUX
bjp-13842	124	12	be	be	AUX
bjp-13842	124	13	classified	classify	VERB
bjp-13842	124	14	into	into	ADP
bjp-13842	124	15	4	4	NUM
bjp-13842	124	16	groups	group	NOUN
bjp-13842	124	17	based	base	VERB
bjp-13842	124	18	on	on	ADP
bjp-13842	124	19	their	their	PRON
bjp-13842	124	20	homology	homology	NOUN
bjp-13842	124	21	with	with	ADP
bjp-13842	124	22	yeast	yeast	NOUN
bjp-13842	124	23	hdacs	hdac	NOUN
bjp-13842	124	24	(	(	PUNCT
bjp-13842	124	25	de	de	X
bjp-13842	124	26	ruijter	ruijter	NOUN
bjp-13842	124	27	et	et	PROPN
bjp-13842	124	28	al	al	PROPN
bjp-13842	124	29	.	.	PROPN
bjp-13842	124	30	,	,	PUNCT
bjp-13842	124	31	2003	2003	NUM
bjp-13842	124	32	;	;	PUNCT
bjp-13842	124	33	blander	bland	ADJ
bjp-13842	124	34	and	and	CCONJ
bjp-13842	124	35	guarente	guarente	ADJ
bjp-13842	124	36	,	,	PUNCT
bjp-13842	124	37	2004	2004	NUM
bjp-13842	124	38	)	)	PUNCT
bjp-13842	124	39	.	.	PUNCT
bjp-13842	125	1	histone	histone	NOUN
bjp-13842	125	2	acetylation	acetylation	NOUN
bjp-13842	125	3	or	or	CCONJ
bjp-13842	125	4	deacetylation	deacetylation	NOUN
bjp-13842	125	5	is	be	AUX
bjp-13842	125	6	thought	think	VERB
bjp-13842	125	7	to	to	PART
bjp-13842	125	8	facilitate	facilitate	VERB
bjp-13842	125	9	or	or	CCONJ
bjp-13842	125	10	inhibit	inhibit	VERB
bjp-13842	125	11	gene	gene	NOUN
bjp-13842	125	12	transcription	transcription	NOUN
bjp-13842	125	13	.	.	PUNCT
bjp-13842	126	1	besides	besides	SCONJ
bjp-13842	126	2	regulating	regulate	VERB
bjp-13842	126	3	histone	histone	NOUN
bjp-13842	126	4	modification	modification	NOUN
bjp-13842	126	5	,	,	PUNCT
bjp-13842	126	6	hdacs	hdac	NOUN
bjp-13842	126	7	can	can	AUX
bjp-13842	126	8	also	also	ADV
bjp-13842	126	9	regulate	regulate	VERB
bjp-13842	126	10	the	the	DET
bjp-13842	126	11	post	post	ADJ
bjp-13842	126	12	-	-	ADJ
bjp-13842	126	13	translational	translational	ADJ
bjp-13842	126	14	acetylation	acetylation	NOUN
bjp-13842	126	15	of	of	ADP
bjp-13842	126	16	many	many	ADJ
bjp-13842	126	17	non	non	ADJ
bjp-13842	126	18	-	-	ADJ
bjp-13842	126	19	histone	histone	ADJ
bjp-13842	126	20	proteins	protein	NOUN
bjp-13842	126	21	,	,	PUNCT
bjp-13842	126	22	including	include	VERB
bjp-13842	126	23	transcription	transcription	NOUN
bjp-13842	126	24	factors	factor	NOUN
bjp-13842	126	25	,	,	PUNCT
bjp-13842	126	26	chaperones	chaperone	NOUN
bjp-13842	126	27	and	and	CCONJ
bjp-13842	126	28	signaling	signal	VERB
bjp-13842	126	29	molecules	molecule	NOUN
bjp-13842	126	30	(	(	PUNCT
bjp-13842	126	31	glozak	glozak	NOUN
bjp-13842	126	32	et	et	PROPN
bjp-13842	126	33	al	al	PROPN
bjp-13842	126	34	.	.	PROPN
bjp-13842	126	35	,	,	PUNCT
bjp-13842	126	36	2005	2005	NUM
bjp-13842	126	37	)	)	PUNCT
bjp-13842	126	38	.	.	PUNCT
bjp-13842	127	1	the	the	DET
bjp-13842	127	2	acetylation	acetylation	NOUN
bjp-13842	127	3	of	of	ADP
bjp-13842	127	4	these	these	DET
bjp-13842	127	5	proteins	protein	NOUN
bjp-13842	127	6	is	be	AUX
bjp-13842	127	7	usually	usually	ADV
bjp-13842	127	8	reversibly	reversibly	ADV
bjp-13842	127	9	regulated	regulate	VERB
bjp-13842	127	10	by	by	ADP
bjp-13842	127	11	the	the	DET
bjp-13842	127	12	dynamic	dynamic	ADJ
bjp-13842	127	13	balance	balance	NOUN
bjp-13842	127	14	between	between	ADP
bjp-13842	127	15	acetyl	acetyl	NOUN
bjp-13842	127	16	transferases	transferase	NOUN
bjp-13842	127	17	(	(	PUNCT
bjp-13842	127	18	hats	hat	NOUN
bjp-13842	127	19	)	)	PUNCT
bjp-13842	127	20	and	and	CCONJ
bjp-13842	127	21	hdacs	hdac	NOUN
bjp-13842	127	22	.	.	PUNCT
bjp-13842	128	1	a	a	DET
bjp-13842	128	2	large	large	ADJ
bjp-13842	128	3	number	number	NOUN
bjp-13842	128	4	of	of	ADP
bjp-13842	128	5	hdac	hdac	NOUN
bjp-13842	128	6	inhibitors	inhibitor	NOUN
bjp-13842	128	7	have	have	AUX
bjp-13842	128	8	been	be	AUX
bjp-13842	128	9	purified	purify	VERB
bjp-13842	128	10	from	from	ADP
bjp-13842	128	11	natural	natural	ADJ
bjp-13842	128	12	sources	source	NOUN
bjp-13842	128	13	,	,	PUNCT
bjp-13842	128	14	or	or	CCONJ
bjp-13842	128	15	synthesized	synthesize	VERB
bjp-13842	128	16	.	.	PUNCT
bjp-13842	129	1	the	the	DET
bjp-13842	129	2	mechanisms	mechanism	NOUN
bjp-13842	129	3	of	of	ADP
bjp-13842	129	4	action	action	NOUN
bjp-13842	129	5	of	of	ADP
bjp-13842	129	6	hdac	hdac	NOUN
bjp-13842	129	7	inhibitors	inhibitor	NOUN
bjp-13842	129	8	are	be	AUX
bjp-13842	129	9	thought	think	VERB
bjp-13842	129	10	to	to	PART
bjp-13842	129	11	be	be	AUX
bjp-13842	129	12	related	relate	VERB
bjp-13842	129	13	to	to	ADP
bjp-13842	129	14	the	the	DET
bjp-13842	129	15	alteration	alteration	NOUN
bjp-13842	129	16	of	of	ADP
bjp-13842	129	17	gene	gene	NOUN
bjp-13842	129	18	expression	expression	NOUN
bjp-13842	129	19	and	and	CCONJ
bjp-13842	129	20	the	the	DET
bjp-13842	129	21	changes	change	NOUN
bjp-13842	129	22	in	in	ADP
bjp-13842	129	23	non	non	ADJ
bjp-13842	129	24	-	-	ADJ
bjp-13842	129	25	histone	histone	ADJ
bjp-13842	129	26	proteins	protein	NOUN
bjp-13842	129	27	at	at	ADP
bjp-13842	129	28	epigenetic	epigenetic	ADJ
bjp-13842	129	29	and	and	CCONJ
bjp-13842	129	30	post	post	ADJ
bjp-13842	129	31	-	-	ADJ
bjp-13842	129	32	translational	translational	ADJ
bjp-13842	129	33	levels	level	NOUN
bjp-13842	129	34	,	,	PUNCT
bjp-13842	129	35	respectively	respectively	ADV
bjp-13842	129	36	(	(	PUNCT
bjp-13842	129	37	kim	kim	PROPN
bjp-13842	129	38	and	and	CCONJ
bjp-13842	129	39	bae	bae	PROPN
bjp-13842	129	40	,	,	PUNCT
bjp-13842	129	41	2011	2011	NUM
bjp-13842	129	42	)	)	PUNCT
bjp-13842	129	43	.	.	PUNCT
bjp-13842	130	1	tsa	tsa	NOUN
bjp-13842	130	2	is	be	AUX
bjp-13842	130	3	the	the	DET
bjp-13842	130	4	first	first	ADJ
bjp-13842	130	5	natural	natural	ADJ
bjp-13842	130	6	hydroxamate	hydroxamate	NOUN
bjp-13842	130	7	found	find	VERB
bjp-13842	130	8	to	to	PART
bjp-13842	130	9	inhibit	inhibit	VERB
bjp-13842	130	10	class	class	NOUN
bjp-13842	130	11	i	i	PROPN
bjp-13842	130	12	and	and	CCONJ
bjp-13842	130	13	ii	ii	PROPN
bjp-13842	130	14	hdacs	hdac	NOUN
bjp-13842	130	15	exhibiting	exhibit	VERB
bjp-13842	130	16	powerful	powerful	ADJ
bjp-13842	130	17	anti	anti	ADJ
bjp-13842	130	18	-	-	ADJ
bjp-13842	130	19	cancer	cancer	ADJ
bjp-13842	130	20	effect	effect	NOUN
bjp-13842	130	21	via	via	ADP
bjp-13842	130	22	inhibiting	inhibit	VERB
bjp-13842	130	23	tumor	tumor	NOUN
bjp-13842	130	24	angiogenesis	angiogenesis	NOUN
bjp-13842	130	25	,	,	PUNCT
bjp-13842	130	26	which	which	PRON
bjp-13842	130	27	may	may	AUX
bjp-13842	130	28	be	be	AUX
bjp-13842	130	29	related	relate	VERB
bjp-13842	130	30	to	to	ADP
bjp-13842	130	31	the	the	DET
bjp-13842	130	32	suppression	suppression	NOUN
bjp-13842	130	33	of	of	ADP
bjp-13842	130	34	hif-1α	hif-1α	PROPN
bjp-13842	130	35	(	(	PUNCT
bjp-13842	130	36	kim	kim	PROPN
bjp-13842	130	37	et	et	PROPN
bjp-13842	130	38	al	al	PROPN
bjp-13842	130	39	.	.	PROPN
bjp-13842	130	40	,	,	PUNCT
bjp-13842	130	41	2001	2001	NUM
bjp-13842	130	42	)	)	PUNCT
bjp-13842	130	43	.	.	PUNCT
bjp-13842	131	1	the	the	DET
bjp-13842	131	2	effect	effect	NOUN
bjp-13842	131	3	of	of	ADP
bjp-13842	131	4	hdac	hdac	NOUN
bjp-13842	131	5	inhibitors	inhibitor	NOUN
bjp-13842	131	6	on	on	ADP
bjp-13842	131	7	hif-1α	hif-1α	NOUN
bjp-13842	131	8	has	have	AUX
bjp-13842	131	9	been	be	AUX
bjp-13842	131	10	studied	study	VERB
bjp-13842	131	11	extensively	extensively	ADV
bjp-13842	131	12	.	.	PUNCT
bjp-13842	132	1	in	in	ADP
bjp-13842	132	2	the	the	DET
bjp-13842	132	3	current	current	ADJ
bjp-13842	132	4	study	study	NOUN
bjp-13842	132	5	,	,	PUNCT
bjp-13842	132	6	the	the	DET
bjp-13842	132	7	effect	effect	NOUN
bjp-13842	132	8	of	of	ADP
bjp-13842	132	9	tsa	tsa	NOUN
bjp-13842	132	10	on	on	ADP
bjp-13842	132	11	hif-2α	hif-2α	PROPN
bjp-13842	132	12	was	be	AUX
bjp-13842	132	13	investigated	investigate	VERB
bjp-13842	132	14	.	.	PUNCT
bjp-13842	133	1	our	our	PRON
bjp-13842	133	2	findings	finding	NOUN
bjp-13842	133	3	indicated	indicate	VERB
bjp-13842	133	4	that	that	SCONJ
bjp-13842	133	5	tsa	tsa	NOUN
bjp-13842	133	6	destabilized	destabilize	VERB
bjp-13842	133	7	hif-2α	hif-2α	NOUN
bjp-13842	133	8	in	in	ADP
bjp-13842	133	9	a	a	DET
bjp-13842	133	10	vhl	vhl	NOUN
bjp-13842	133	11	-	-	PUNCT
bjp-13842	133	12	independent	independent	ADJ
bjp-13842	133	13	,	,	PUNCT
bjp-13842	133	14	but	but	CCONJ
bjp-13842	133	15	proteasome	proteasome	NOUN
bjp-13842	133	16	-	-	PUNCT
bjp-13842	133	17	dependent	dependent	ADJ
bjp-13842	133	18	way	way	NOUN
bjp-13842	133	19	.	.	PUNCT
bjp-13842	134	1	in	in	ADP
bjp-13842	134	2	cancer	cancer	NOUN
bjp-13842	134	3	-	-	PUNCT
bjp-13842	134	4	bearing	bear	VERB
bjp-13842	134	5	nude	nude	ADJ
bjp-13842	134	6	mice	mouse	NOUN
bjp-13842	134	7	,	,	PUNCT
bjp-13842	134	8	tsa	tsa	NOUN
bjp-13842	134	9	significantly	significantly	ADV
bjp-13842	134	10	inhibited	inhibit	VERB
bjp-13842	134	11	the	the	DET
bjp-13842	134	12	tumor	tumor	NOUN
bjp-13842	134	13	growth	growth	NOUN
bjp-13842	134	14	,	,	PUNCT
bjp-13842	134	15	and	and	CCONJ
bjp-13842	134	16	more	more	ADV
bjp-13842	134	17	importantly	importantly	ADV
bjp-13842	134	18	,	,	PUNCT
bjp-13842	134	19	it	it	PRON
bjp-13842	134	20	destabilized	destabilize	VERB
bjp-13842	134	21	hif-2α	hif-2α	NOUN
bjp-13842	134	22	in	in	ADP
bjp-13842	134	23	vivo	vivo	NOUN
bjp-13842	134	24	,	,	PUNCT
bjp-13842	134	25	suggesting	suggest	VERB
bjp-13842	134	26	that	that	SCONJ
bjp-13842	134	27	the	the	DET
bjp-13842	134	28	anti	anti	ADJ
bjp-13842	134	29	-	-	ADJ
bjp-13842	134	30	cancer	cancer	ADJ
bjp-13842	134	31	effect	effect	NOUN
bjp-13842	134	32	of	of	ADP
bjp-13842	134	33	tsa	tsa	NOUN
bjp-13842	134	34	is	be	AUX
bjp-13842	134	35	at	at	ADV
bjp-13842	134	36	least	least	ADV
bjp-13842	134	37	partially	partially	ADV
bjp-13842	134	38	mediated	mediate	VERB
bjp-13842	134	39	by	by	ADP
bjp-13842	134	40	its	its	PRON
bjp-13842	134	41	inhibitory	inhibitory	ADJ
bjp-13842	134	42	effect	effect	NOUN
bjp-13842	134	43	on	on	ADP
bjp-13842	134	44	hif2α	hif2α	PROPN
bjp-13842	134	45	.	.	PUNCT
bjp-13842	135	1	in	in	ADP
bjp-13842	135	2	fact	fact	NOUN
bjp-13842	135	3	,	,	PUNCT
bjp-13842	135	4	the	the	DET
bjp-13842	135	5	role	role	NOUN
bjp-13842	135	6	of	of	ADP
bjp-13842	135	7	hif-2α	hif-2α	NOUN
bjp-13842	135	8	in	in	ADP
bjp-13842	135	9	tumor	tumor	NOUN
bjp-13842	135	10	progression	progression	NOUN
bjp-13842	135	11	has	have	AUX
bjp-13842	135	12	attracted	attract	VERB
bjp-13842	135	13	more	more	ADJ
bjp-13842	135	14	attentions	attention	NOUN
bjp-13842	135	15	in	in	ADP
bjp-13842	135	16	recent	recent	ADJ
bjp-13842	135	17	years	year	NOUN
bjp-13842	135	18	for	for	ADP
bjp-13842	135	19	the	the	DET
bjp-13842	135	20	following	follow	VERB
bjp-13842	135	21	reasons	reason	NOUN
bjp-13842	135	22	.	.	PUNCT
bjp-13842	136	1	first	first	ADV
bjp-13842	136	2	,	,	PUNCT
bjp-13842	136	3	although	although	SCONJ
bjp-13842	136	4	hif-1α	hif-1α	NOUN
bjp-13842	136	5	and	and	CCONJ
bjp-13842	136	6	hif-2α	hif-2α	NOUN
bjp-13842	136	7	are	be	AUX
bjp-13842	136	8	highly	highly	ADV
bjp-13842	136	9	homologous	homologous	ADJ
bjp-13842	136	10	,	,	PUNCT
bjp-13842	136	11	increasing	increase	VERB
bjp-13842	136	12	evidence	evidence	NOUN
bjp-13842	136	13	suggests	suggest	VERB
bjp-13842	136	14	they	they	PRON
bjp-13842	136	15	have	have	VERB
bjp-13842	136	16	distinct	distinct	ADJ
bjp-13842	136	17	transcriptional	transcriptional	ADJ
bjp-13842	136	18	targets	target	NOUN
bjp-13842	136	19	and	and	CCONJ
bjp-13842	136	20	different	different	ADJ
bjp-13842	136	21	influences	influence	NOUN
bjp-13842	136	22	on	on	ADP
bjp-13842	136	23	tumor	tumor	NOUN
bjp-13842	136	24	growth	growth	NOUN
bjp-13842	136	25	.	.	PUNCT
bjp-13842	137	1	furthermore	furthermore	ADV
bjp-13842	137	2	,	,	PUNCT
bjp-13842	137	3	the	the	DET
bjp-13842	137	4	nontranscriptional	nontranscriptional	ADJ
bjp-13842	137	5	effects	effect	NOUN
bjp-13842	137	6	of	of	ADP
bjp-13842	137	7	hif	hif	PROPN
bjp-13842	137	8	-	-	PUNCT
bjp-13842	137	9	α	α	PROPN
bjp-13842	137	10	subunits	subunit	NOUN
bjp-13842	137	11	,	,	PUNCT
bjp-13842	137	12	including	include	VERB
bjp-13842	137	13	146	146	NUM
bjp-13842	137	14	bangladesh	bangladesh	PROPN
bjp-13842	137	15	j	j	PROPN
bjp-13842	137	16	pharmacol	pharmacol	PROPN
bjp-13842	137	17	2013	2013	NUM
bjp-13842	137	18	;	;	PUNCT
bjp-13842	137	19	8	8	NUM
bjp-13842	137	20	:	:	SYM
bjp-13842	137	21	142	142	NUM
bjp-13842	137	22	-	-	SYM
bjp-13842	137	23	148	148	NUM
bjp-13842	137	24	figure	figure	NOUN
bjp-13842	137	25	2	2	NUM
bjp-13842	137	26	:	:	PUNCT
bjp-13842	137	27	tsa	tsa	NOUN
bjp-13842	137	28	-	-	PUNCT
bjp-13842	137	29	induced	induce	VERB
bjp-13842	137	30	hif-2α	hif-2α	NOUN
bjp-13842	137	31	degradation	degradation	NOUN
bjp-13842	137	32	is	be	AUX
bjp-13842	137	33	proteasome	proteasome	VERB
bjp-13842	137	34	dependent	dependent	ADJ
bjp-13842	137	35	but	but	CCONJ
bjp-13842	137	36	vhl	vhl	NOUN
bjp-13842	137	37	-	-	PUNCT
bjp-13842	137	38	independent	independent	ADJ
bjp-13842	137	39	(	(	PUNCT
bjp-13842	137	40	a	a	PRON
bjp-13842	137	41	)	)	PUNCT
bjp-13842	137	42	mg-63	mg-63	NOUN
bjp-13842	137	43	cells	cell	NOUN
bjp-13842	137	44	were	be	AUX
bjp-13842	137	45	treated	treat	VERB
bjp-13842	137	46	in	in	ADP
bjp-13842	137	47	hypoxia	hypoxia	NOUN
bjp-13842	137	48	(	(	PUNCT
bjp-13842	137	49	1	1	NUM
bjp-13842	137	50	%	%	NOUN
bjp-13842	137	51	o2	o2	PROPN
bjp-13842	137	52	)	)	PUNCT
bjp-13842	137	53	for	for	ADP
bjp-13842	137	54	8	8	NUM
bjp-13842	137	55	hours	hour	NOUN
bjp-13842	137	56	in	in	ADP
bjp-13842	137	57	the	the	DET
bjp-13842	137	58	presence	presence	NOUN
bjp-13842	137	59	of	of	ADP
bjp-13842	137	60	tsa	tsa	NOUN
bjp-13842	137	61	at	at	ADP
bjp-13842	137	62	300	300	NUM
bjp-13842	137	63	or	or	CCONJ
bjp-13842	137	64	600	600	NUM
bjp-13842	137	65	nm	nm	NOUN
bjp-13842	137	66	without	without	ADP
bjp-13842	137	67	or	or	CCONJ
bjp-13842	137	68	with	with	ADP
bjp-13842	137	69	5	5	NUM
bjp-13842	137	70	μm	μm	NOUN
bjp-13842	137	71	proteasome	proteasome	NOUN
bjp-13842	137	72	inhibitor	inhibitor	NOUN
bjp-13842	137	73	mg132	mg132	PROPN
bjp-13842	137	74	.	.	PROPN
bjp-13842	137	75	cell	cell	NOUN
bjp-13842	137	76	extracts	extract	NOUN
bjp-13842	137	77	were	be	AUX
bjp-13842	137	78	subjected	subject	VERB
bjp-13842	137	79	to	to	ADP
bjp-13842	137	80	western	western	ADJ
bjp-13842	137	81	blot	blot	NOUN
bjp-13842	137	82	assay	assay	VERB
bjp-13842	137	83	for	for	ADP
bjp-13842	137	84	hif-2α	hif-2α	NOUN
bjp-13842	137	85	and	and	CCONJ
bjp-13842	137	86	tubulin	tubulin	NOUN
bjp-13842	137	87	.	.	PUNCT
bjp-13842	138	1	(	(	PUNCT
bjp-13842	138	2	b	b	X
bjp-13842	138	3	)	)	PUNCT
bjp-13842	138	4	vhl	vhl	PROPN
bjp-13842	138	5	deficient	deficient	ADJ
bjp-13842	138	6	(	(	PUNCT
bjp-13842	138	7	-/-	-/-	PROPN
bjp-13842	138	8	)	)	PUNCT
bjp-13842	138	9	786	786	NUM
bjp-13842	138	10	-	-	SYM
bjp-13842	138	11	0	0	NUM
bjp-13842	138	12	cells	cell	NOUN
bjp-13842	138	13	were	be	AUX
bjp-13842	138	14	treated	treat	VERB
bjp-13842	138	15	with	with	ADP
bjp-13842	138	16	tsa	tsa	NOUN
bjp-13842	138	17	at	at	ADP
bjp-13842	138	18	different	different	ADJ
bjp-13842	138	19	concentrations	concentration	NOUN
bjp-13842	138	20	without	without	ADP
bjp-13842	138	21	or	or	CCONJ
bjp-13842	138	22	with	with	ADP
bjp-13842	138	23	5	5	NUM
bjp-13842	138	24	μm	μm	NOUN
bjp-13842	138	25	proteasome	proteasome	NOUN
bjp-13842	138	26	inhibitor	inhibitor	NOUN
bjp-13842	138	27	mg132	mg132	PROPN
bjp-13842	138	28	in	in	ADP
bjp-13842	138	29	normoxia	normoxia	NOUN
bjp-13842	138	30	for	for	ADP
bjp-13842	138	31	8	8	NUM
bjp-13842	138	32	hours	hour	NOUN
bjp-13842	138	33	.	.	PUNCT
bjp-13842	139	1	cell	cell	NOUN
bjp-13842	139	2	extracts	extract	NOUN
bjp-13842	139	3	were	be	AUX
bjp-13842	139	4	subjected	subject	VERB
bjp-13842	139	5	to	to	ADP
bjp-13842	139	6	western	western	ADJ
bjp-13842	139	7	blot	blot	NOUN
bjp-13842	139	8	assay	assay	VERB
bjp-13842	139	9	for	for	ADP
bjp-13842	139	10	hif-2α	hif-2α	NOUN
bjp-13842	139	11	and	and	CCONJ
bjp-13842	139	12	tubulin	tubulin	NOUN
bjp-13842	139	13	.	.	PUNCT
bjp-13842	140	1	(	(	PUNCT
bjp-13842	140	2	c	c	X
bjp-13842	140	3	)	)	PUNCT
bjp-13842	140	4	5	5	NUM
bjp-13842	140	5	μg	μg	NOUN
bjp-13842	140	6	of	of	ADP
bjp-13842	140	7	flag	flag	NOUN
bjp-13842	140	8	-	-	PUNCT
bjp-13842	140	9	tagged	tag	VERB
bjp-13842	140	10	wild	wild	ADJ
bjp-13842	140	11	type	type	NOUN
bjp-13842	140	12	hif	hif	PROPN
bjp-13842	140	13	-2α	-2α	VERB
bjp-13842	140	14	plasmid	plasmid	ADJ
bjp-13842	140	15	or	or	CCONJ
bjp-13842	140	16	prolyl	prolyl	VERB
bjp-13842	140	17	residues	residue	NOUN
bjp-13842	140	18	405	405	NUM
bjp-13842	140	19	and	and	CCONJ
bjp-13842	140	20	531	531	NUM
bjp-13842	140	21	mutant	mutant	NOUN
bjp-13842	140	22	(	(	PUNCT
bjp-13842	140	23	hif-2α	hif-2α	NOUN
bjp-13842	140	24	2	2	NUM
bjp-13842	140	25	pm	pm	NOUN
bjp-13842	140	26	)	)	PUNCT
bjp-13842	140	27	were	be	AUX
bjp-13842	140	28	transfected	transfecte	VERB
bjp-13842	140	29	into	into	ADP
bjp-13842	140	30	mg-63	mg-63	NOUN
bjp-13842	140	31	cells	cell	NOUN
bjp-13842	140	32	at	at	ADP
bjp-13842	140	33	80	80	NUM
bjp-13842	140	34	%	%	NOUN
bjp-13842	140	35	cell	cell	NOUN
bjp-13842	140	36	confluence	confluence	NOUN
bjp-13842	140	37	with	with	ADP
bjp-13842	140	38	lipofectamine	lipofectamine	PROPN
bjp-13842	140	39	2000	2000	NUM
bjp-13842	140	40	.	.	PUNCT
bjp-13842	141	1	one	one	NUM
bjp-13842	141	2	day	day	NOUN
bjp-13842	141	3	later	later	ADV
bjp-13842	141	4	,	,	PUNCT
bjp-13842	141	5	cells	cell	NOUN
bjp-13842	141	6	were	be	AUX
bjp-13842	141	7	evenly	evenly	ADV
bjp-13842	141	8	split	split	VERB
bjp-13842	141	9	into	into	ADP
bjp-13842	141	10	3	3	NUM
bjp-13842	141	11	plates	plate	NOUN
bjp-13842	141	12	and	and	CCONJ
bjp-13842	141	13	exposed	expose	VERB
bjp-13842	141	14	to	to	ADP
bjp-13842	141	15	hypoxia	hypoxia	NOUN
bjp-13842	141	16	(	(	PUNCT
bjp-13842	141	17	1%o2	1%o2	NUM
bjp-13842	141	18	)	)	PUNCT
bjp-13842	141	19	for	for	ADP
bjp-13842	141	20	8	8	NUM
bjp-13842	141	21	hours	hour	NOUN
bjp-13842	141	22	with	with	ADP
bjp-13842	141	23	tsa	tsa	NOUN
bjp-13842	141	24	at	at	ADP
bjp-13842	141	25	different	different	ADJ
bjp-13842	141	26	concentrations	concentration	NOUN
bjp-13842	141	27	,	,	PUNCT
bjp-13842	141	28	and	and	CCONJ
bjp-13842	141	29	cells	cell	NOUN
bjp-13842	141	30	extracts	extract	NOUN
bjp-13842	141	31	were	be	AUX
bjp-13842	141	32	subjected	subject	VERB
bjp-13842	141	33	to	to	ADP
bjp-13842	141	34	immunoblotting	immunoblotte	VERB
bjp-13842	141	35	with	with	ADP
bjp-13842	141	36	anti	anti	ADJ
bjp-13842	141	37	-	-	ADJ
bjp-13842	141	38	flag	flag	ADJ
bjp-13842	141	39	and	and	CCONJ
bjp-13842	141	40	antitubulin	antitubulin	NOUN
bjp-13842	141	41	antibodies	antibody	NOUN
bjp-13842	141	42	figure	figure	VERB
bjp-13842	141	43	3	3	NUM
bjp-13842	141	44	:	:	PUNCT
bjp-13842	141	45	effect	effect	NOUN
bjp-13842	141	46	of	of	ADP
bjp-13842	141	47	tsa	tsa	NOUN
bjp-13842	141	48	on	on	ADP
bjp-13842	141	49	tumor	tumor	NOUN
bjp-13842	141	50	growth	growth	NOUN
bjp-13842	141	51	and	and	CCONJ
bjp-13842	141	52	hif-2α	hif-2α	NOUN
bjp-13842	141	53	expression	expression	NOUN
bjp-13842	141	54	in	in	ADP
bjp-13842	141	55	vivo	vivo	NOUN
bjp-13842	141	56	(	(	PUNCT
bjp-13842	141	57	a	a	PRON
bjp-13842	141	58	)	)	PUNCT
bjp-13842	141	59	mg-63	mg-63	NOUN
bjp-13842	141	60	cells	cell	NOUN
bjp-13842	141	61	were	be	AUX
bjp-13842	141	62	inoculated	inoculate	VERB
bjp-13842	141	63	into	into	ADP
bjp-13842	141	64	nude	nude	ADJ
bjp-13842	141	65	mice	mouse	NOUN
bjp-13842	141	66	to	to	PART
bjp-13842	141	67	induce	induce	VERB
bjp-13842	141	68	subcutaneous	subcutaneous	ADJ
bjp-13842	141	69	tumors	tumor	NOUN
bjp-13842	141	70	.	.	PUNCT
bjp-13842	142	1	one	one	NUM
bjp-13842	142	2	week	week	NOUN
bjp-13842	142	3	later	later	ADV
bjp-13842	142	4	,	,	PUNCT
bjp-13842	142	5	mice	mouse	NOUN
bjp-13842	142	6	were	be	AUX
bjp-13842	142	7	randomly	randomly	ADV
bjp-13842	142	8	divided	divide	VERB
bjp-13842	142	9	into	into	ADP
bjp-13842	142	10	control	control	NOUN
bjp-13842	142	11	,	,	PUNCT
bjp-13842	142	12	tsa	tsa	NOUN
bjp-13842	142	13	and	and	CCONJ
bjp-13842	142	14	ctx	ctx	NOUN
bjp-13842	142	15	groups	group	NOUN
bjp-13842	142	16	,	,	PUNCT
bjp-13842	142	17	in	in	ADP
bjp-13842	142	18	which	which	PRON
bjp-13842	142	19	mice	mouse	NOUN
bjp-13842	142	20	were	be	AUX
bjp-13842	142	21	treated	treat	VERB
bjp-13842	142	22	with	with	ADP
bjp-13842	142	23	normal	normal	ADJ
bjp-13842	142	24	saline	saline	NOUN
bjp-13842	142	25	(	(	PUNCT
bjp-13842	142	26	control	control	NOUN
bjp-13842	142	27	group	group	NOUN
bjp-13842	142	28	)	)	PUNCT
bjp-13842	142	29	,	,	PUNCT
bjp-13842	142	30	tsa	tsa	NOUN
bjp-13842	142	31	and	and	CCONJ
bjp-13842	142	32	ctx	ctx	NOUN
bjp-13842	142	33	,	,	PUNCT
bjp-13842	142	34	respectively	respectively	ADV
bjp-13842	142	35	,	,	PUNCT
bjp-13842	142	36	for	for	ADP
bjp-13842	142	37	17	17	NUM
bjp-13842	142	38	days	day	NOUN
bjp-13842	142	39	.	.	PUNCT
bjp-13842	143	1	data	datum	NOUN
bjp-13842	143	2	were	be	AUX
bjp-13842	143	3	expressed	express	VERB
bjp-13842	143	4	as	as	ADP
bjp-13842	143	5	mean	mean	NOUN
bjp-13842	143	6	±	±	NUM
bjp-13842	143	7	standard	standard	ADJ
bjp-13842	143	8	error	error	NOUN
bjp-13842	143	9	(	(	PUNCT
bjp-13842	143	10	sem	sem	NOUN
bjp-13842	143	11	)	)	PUNCT
bjp-13842	143	12	.	.	PUNCT
bjp-13842	144	1	(	(	PUNCT
bjp-13842	144	2	b	b	X
bjp-13842	144	3	)	)	PUNCT
bjp-13842	144	4	tumors	tumor	NOUN
bjp-13842	144	5	were	be	AUX
bjp-13842	144	6	harvested	harvest	VERB
bjp-13842	144	7	and	and	CCONJ
bjp-13842	144	8	homogenized	homogenize	VERB
bjp-13842	144	9	;	;	PUNCT
bjp-13842	144	10	protein	protein	NOUN
bjp-13842	144	11	was	be	AUX
bjp-13842	144	12	subjected	subject	VERB
bjp-13842	144	13	to	to	ADP
bjp-13842	144	14	sds	sds	NOUN
bjp-13842	144	15	-	-	PUNCT
bjp-13842	144	16	page	page	NOUN
bjp-13842	144	17	followed	follow	VERB
bjp-13842	144	18	by	by	ADP
bjp-13842	144	19	immunoblotting	immunoblotte	VERB
bjp-13842	144	20	for	for	ADP
bjp-13842	144	21	hif-2α	hif-2α	NOUN
bjp-13842	144	22	and	and	CCONJ
bjp-13842	144	23	tubulin	tubulin	NOUN
bjp-13842	144	24	.	.	PUNCT
bjp-13842	145	1	c1	c1	PROPN
bjp-13842	145	2	,	,	PUNCT
bjp-13842	145	3	c2	c2	PROPN
bjp-13842	145	4	:	:	PUNCT
bjp-13842	145	5	control	control	NOUN
bjp-13842	145	6	group	group	NOUN
bjp-13842	145	7	;	;	PUNCT
bjp-13842	145	8	1	1	NUM
bjp-13842	145	9	,	,	PUNCT
bjp-13842	145	10	2	2	NUM
bjp-13842	145	11	,	,	PUNCT
bjp-13842	145	12	3	3	NUM
bjp-13842	145	13	,	,	PUNCT
bjp-13842	145	14	4	4	NUM
bjp-13842	145	15	,	,	PUNCT
bjp-13842	145	16	5	5	NUM
bjp-13842	145	17	:	:	PUNCT
bjp-13842	145	18	tsa	tsa	NOUN
bjp-13842	145	19	-	-	PUNCT
bjp-13842	145	20	treated	treat	VERB
bjp-13842	145	21	group	group	NOUN
bjp-13842	145	22	tu	tu	PROPN
bjp-13842	145	23	m	m	PROPN
bjp-13842	145	24	or	or	CCONJ
bjp-13842	145	25	v	v	ADP
bjp-13842	145	26	ol	ol	ADJ
bjp-13842	145	27	um	um	INTJ
bjp-13842	145	28	e	e	PROPN
bjp-13842	145	29	(	(	PUNCT
bjp-13842	145	30	c	c	NOUN
bjp-13842	145	31	m	m	PROPN
bjp-13842	145	32	3	3	NUM
bjp-13842	145	33	)	)	PUNCT
bjp-13842	145	34	3.5	3.5	NUM
bjp-13842	145	35	3	3	NUM
bjp-13842	145	36	2.5	2.5	NUM
bjp-13842	145	37	2	2	NUM
bjp-13842	145	38	1.5	1.5	NUM
bjp-13842	145	39	1	1	NUM
bjp-13842	145	40	0.5	0.5	NUM
bjp-13842	145	41	0	0	NUM
bjp-13842	145	42	0	0	NUM
bjp-13842	145	43	4	4	NUM
bjp-13842	145	44	7	7	NUM
bjp-13842	145	45	10	10	NUM
bjp-13842	145	46	14	14	NUM
bjp-13842	145	47	17	17	NUM
bjp-13842	145	48	days	day	NOUN
bjp-13842	145	49	of	of	ADP
bjp-13842	145	50	treatment	treatment	NOUN
bjp-13842	145	51	control	control	NOUN
bjp-13842	145	52	ctx	ctx	PROPN
bjp-13842	145	53	tsa	tsa	PROPN
bjp-13842	145	54	hif2α	hif2α	PROPN
bjp-13842	145	55	tubulin	tubulin	NOUN
bjp-13842	145	56	c1	c1	NOUN
bjp-13842	145	57	1	1	NUM
bjp-13842	145	58	2	2	NUM
bjp-13842	145	59	3	3	NUM
bjp-13842	145	60	4	4	NUM
bjp-13842	145	61	5	5	NUM
bjp-13842	145	62	c2	c2	PROPN
bjp-13842	145	63	a	a	DET
bjp-13842	145	64	b	b	NOUN
bjp-13842	145	65	effects	effect	NOUN
bjp-13842	145	66	on	on	ADP
bjp-13842	145	67	notch	notch	NOUN
bjp-13842	145	68	and	and	CCONJ
bjp-13842	145	69	c	c	NOUN
bjp-13842	145	70	-	-	PUNCT
bjp-13842	145	71	myc	myc	NOUN
bjp-13842	145	72	pathways	pathway	NOUN
bjp-13842	145	73	,	,	PUNCT
bjp-13842	145	74	contribute	contribute	VERB
bjp-13842	145	75	to	to	ADP
bjp-13842	145	76	their	their	PRON
bjp-13842	145	77	distinct	distinct	ADJ
bjp-13842	145	78	functions	function	NOUN
bjp-13842	145	79	(	(	PUNCT
bjp-13842	145	80	qing	qing	NOUN
bjp-13842	145	81	and	and	CCONJ
bjp-13842	145	82	simon	simon	PROPN
bjp-13842	145	83	,	,	PUNCT
bjp-13842	145	84	2009	2009	NUM
bjp-13842	145	85	;	;	PUNCT
bjp-13842	145	86	patel	patel	PROPN
bjp-13842	145	87	and	and	CCONJ
bjp-13842	145	88	simon	simon	PROPN
bjp-13842	145	89	,	,	PUNCT
bjp-13842	145	90	2008	2008	NUM
bjp-13842	145	91	)	)	PUNCT
bjp-13842	145	92	.	.	PUNCT
bjp-13842	146	1	the	the	DET
bjp-13842	146	2	transcriptional	transcriptional	ADJ
bjp-13842	146	3	targets	target	NOUN
bjp-13842	146	4	of	of	ADP
bjp-13842	146	5	hif-2α	hif-2α	NOUN
bjp-13842	146	6	include	include	VERB
bjp-13842	146	7	genes	gene	NOUN
bjp-13842	146	8	involved	involve	VERB
bjp-13842	146	9	in	in	ADP
bjp-13842	146	10	the	the	DET
bjp-13842	146	11	erythropoiesis	erythropoiesis	NOUN
bjp-13842	146	12	,	,	PUNCT
bjp-13842	146	13	angiogenesis	angiogenesis	NOUN
bjp-13842	146	14	,	,	PUNCT
bjp-13842	146	15	metastasis	metastasis	NOUN
bjp-13842	146	16	,	,	PUNCT
bjp-13842	146	17	and	and	CCONJ
bjp-13842	146	18	proliferation	proliferation	NOUN
bjp-13842	146	19	.	.	PUNCT
bjp-13842	147	1	therefore	therefore	ADV
bjp-13842	147	2	,	,	PUNCT
bjp-13842	147	3	hif-2α	hif-2α	NOUN
bjp-13842	147	4	plays	play	VERB
bjp-13842	147	5	crucial	crucial	ADJ
bjp-13842	147	6	roles	role	NOUN
bjp-13842	147	7	in	in	ADP
bjp-13842	147	8	both	both	CCONJ
bjp-13842	147	9	physiology	physiology	NOUN
bjp-13842	147	10	and	and	CCONJ
bjp-13842	147	11	tumorigenesis	tumorigenesis	NOUN
bjp-13842	147	12	(	(	PUNCT
bjp-13842	147	13	qing	qing	NOUN
bjp-13842	147	14	and	and	CCONJ
bjp-13842	147	15	simon	simon	PROPN
bjp-13842	147	16	,	,	PUNCT
bjp-13842	147	17	2009	2009	NUM
bjp-13842	147	18	;	;	PUNCT
bjp-13842	147	19	patel	patel	PROPN
bjp-13842	147	20	and	and	CCONJ
bjp-13842	147	21	simon	simon	PROPN
bjp-13842	147	22	,	,	PUNCT
bjp-13842	147	23	2008	2008	NUM
bjp-13842	147	24	)	)	PUNCT
bjp-13842	147	25	.	.	PUNCT
bjp-13842	148	1	second	second	ADJ
bjp-13842	148	2	,	,	PUNCT
bjp-13842	148	3	in	in	ADP
bjp-13842	148	4	some	some	DET
bjp-13842	148	5	cancers	cancer	NOUN
bjp-13842	148	6	such	such	ADJ
bjp-13842	148	7	as	as	ADP
bjp-13842	148	8	neuroblastoma	neuroblastoma	ADJ
bjp-13842	148	9	and	and	CCONJ
bjp-13842	148	10	renal	renal	ADJ
bjp-13842	148	11	clear	clear	ADJ
bjp-13842	148	12	cell	cell	NOUN
bjp-13842	148	13	carcinoma	carcinoma	NOUN
bjp-13842	148	14	,	,	PUNCT
bjp-13842	148	15	hif-2α	hif-2α	NOUN
bjp-13842	148	16	appears	appear	VERB
bjp-13842	148	17	to	to	PART
bjp-13842	148	18	play	play	VERB
bjp-13842	148	19	more	more	ADV
bjp-13842	148	20	important	important	ADJ
bjp-13842	148	21	roles	role	NOUN
bjp-13842	148	22	than	than	ADP
bjp-13842	148	23	hif-1α	hif-1α	NOUN
bjp-13842	148	24	(	(	PUNCT
bjp-13842	148	25	holmquistmengelbier	holmquistmengelbier	NOUN
bjp-13842	148	26	et	et	PROPN
bjp-13842	148	27	al	al	PROPN
bjp-13842	148	28	.	.	PROPN
bjp-13842	148	29	,	,	PUNCT
bjp-13842	148	30	2006	2006	NUM
bjp-13842	148	31	;	;	PUNCT
bjp-13842	148	32	mack	mack	PROPN
bjp-13842	148	33	et	et	PROPN
bjp-13842	148	34	al	al	PROPN
bjp-13842	148	35	.	.	PROPN
bjp-13842	148	36	,	,	PUNCT
bjp-13842	148	37	2003	2003	NUM
bjp-13842	148	38	)	)	PUNCT
bjp-13842	148	39	.	.	PUNCT
bjp-13842	149	1	our	our	PRON
bjp-13842	149	2	findings	finding	NOUN
bjp-13842	149	3	suggest	suggest	VERB
bjp-13842	149	4	that	that	SCONJ
bjp-13842	149	5	tsa	tsa	NOUN
bjp-13842	149	6	can	can	AUX
bjp-13842	149	7	inhibit	inhibit	VERB
bjp-13842	149	8	both	both	PRON
bjp-13842	149	9	hif-1α	hif-1α	NOUN
bjp-13842	149	10	and	and	CCONJ
bjp-13842	149	11	hif-2α	hif-2α	ADJ
bjp-13842	149	12	protein	protein	NOUN
bjp-13842	149	13	expression	expression	NOUN
bjp-13842	149	14	,	,	PUNCT
bjp-13842	149	15	which	which	PRON
bjp-13842	149	16	provides	provide	VERB
bjp-13842	149	17	a	a	DET
bjp-13842	149	18	new	new	ADJ
bjp-13842	149	19	insight	insight	NOUN
bjp-13842	149	20	into	into	ADP
bjp-13842	149	21	the	the	DET
bjp-13842	149	22	molecular	molecular	ADJ
bjp-13842	149	23	mecha	mecha	NOUN
bjp-13842	149	24	-	-	PUNCT
bjp-13842	149	25	nisms	nism	NOUN
bjp-13842	149	26	underlying	underlie	VERB
bjp-13842	149	27	the	the	DET
bjp-13842	149	28	anti	anti	ADJ
bjp-13842	149	29	-	-	ADJ
bjp-13842	149	30	cancer	cancer	ADJ
bjp-13842	149	31	effect	effect	NOUN
bjp-13842	149	32	of	of	ADP
bjp-13842	149	33	hdac	hdac	NOUN
bjp-13842	149	34	inhibitors	inhibitor	NOUN
bjp-13842	149	35	.	.	PUNCT
bjp-13842	150	1	the	the	DET
bjp-13842	150	2	mechanism	mechanism	NOUN
bjp-13842	150	3	underlying	underlie	VERB
bjp-13842	150	4	the	the	DET
bjp-13842	150	5	degradation	degradation	NOUN
bjp-13842	150	6	of	of	ADP
bjp-13842	150	7	hdac	hdac	NOUN
bjp-13842	150	8	inhibitor	inhibitor	NOUN
bjp-13842	150	9	-	-	PUNCT
bjp-13842	150	10	mediated	mediate	VERB
bjp-13842	150	11	hif	hif	PROPN
bjp-13842	150	12	-	-	PUNCT
bjp-13842	150	13	α	α	PROPN
bjp-13842	150	14	still	still	ADV
bjp-13842	150	15	remains	remain	VERB
bjp-13842	150	16	unclear	unclear	ADJ
bjp-13842	150	17	.	.	PUNCT
bjp-13842	151	1	in	in	ADP
bjp-13842	151	2	the	the	DET
bjp-13842	151	3	case	case	NOUN
bjp-13842	151	4	of	of	ADP
bjp-13842	151	5	hif-1α	hif-1α	NOUN
bjp-13842	151	6	,	,	PUNCT
bjp-13842	151	7	a	a	DET
bjp-13842	151	8	couple	couple	NOUN
bjp-13842	151	9	of	of	ADP
bjp-13842	151	10	mechanisms	mechanism	NOUN
bjp-13842	151	11	have	have	AUX
bjp-13842	151	12	been	be	AUX
bjp-13842	151	13	proposed	propose	VERB
bjp-13842	151	14	including	include	VERB
bjp-13842	151	15	direct	direct	ADJ
bjp-13842	151	16	hif-1α	hif-1α	NOUN
bjp-13842	151	17	acetylation	acetylation	NOUN
bjp-13842	151	18	at	at	ADP
bjp-13842	151	19	k532	k532	PROPN
bjp-13842	151	20	site	site	NOUN
bjp-13842	151	21	,	,	PUNCT
bjp-13842	151	22	the	the	DET
bjp-13842	151	23	disruption	disruption	NOUN
bjp-13842	151	24	of	of	ADP
bjp-13842	151	25	chaperone	chaperone	NOUN
bjp-13842	151	26	protein	protein	NOUN
bjp-13842	151	27	(	(	PUNCT
bjp-13842	151	28	hsp70	hsp70	NOUN
bjp-13842	151	29	and	and	CCONJ
bjp-13842	151	30	hsp90	hsp90	ADJ
bjp-13842	151	31	)	)	PUNCT
bjp-13842	151	32	activities	activity	NOUN
bjp-13842	151	33	and	and	CCONJ
bjp-13842	151	34	the	the	DET
bjp-13842	151	35	involvement	involvement	NOUN
bjp-13842	151	36	of	of	ADP
bjp-13842	151	37	tubulin	tubulin	NOUN
bjp-13842	151	38	acetylation	acetylation	NOUN
bjp-13842	151	39	(	(	PUNCT
bjp-13842	151	40	chen	chen	PROPN
bjp-13842	151	41	and	and	CCONJ
bjp-13842	151	42	sang	sing	VERB
bjp-13842	151	43	,	,	PUNCT
bjp-13842	151	44	2011	2011	NUM
bjp-13842	151	45	)	)	PUNCT
bjp-13842	151	46	.	.	PUNCT
bjp-13842	152	1	however	however	ADV
bjp-13842	152	2	,	,	PUNCT
bjp-13842	152	3	its	its	PRON
bjp-13842	152	4	exact	exact	ADJ
bjp-13842	152	5	mechanism	mechanism	NOUN
bjp-13842	152	6	is	be	AUX
bjp-13842	152	7	still	still	ADV
bjp-13842	152	8	controversial	controversial	ADJ
bjp-13842	152	9	(	(	PUNCT
bjp-13842	152	10	chen	chen	PROPN
bjp-13842	152	11	and	and	CCONJ
bjp-13842	152	12	sang	sing	VERB
bjp-13842	152	13	,	,	PUNCT
bjp-13842	152	14	2011	2011	NUM
bjp-13842	152	15	)	)	PUNCT
bjp-13842	152	16	.	.	PUNCT
bjp-13842	153	1	by	by	ADP
bjp-13842	153	2	immunoprecipitation	immunoprecipitation	NOUN
bjp-13842	153	3	,	,	PUNCT
bjp-13842	153	4	our	our	PRON
bjp-13842	153	5	results	result	NOUN
bjp-13842	153	6	showed	show	VERB
bjp-13842	153	7	that	that	SCONJ
bjp-13842	153	8	hif2α	hif2α	PROPN
bjp-13842	153	9	was	be	AUX
bjp-13842	153	10	acetylated	acetylate	VERB
bjp-13842	153	11	by	by	ADP
bjp-13842	153	12	tsa	tsa	NOUN
bjp-13842	153	13	.	.	PUNCT
bjp-13842	154	1	however	however	ADV
bjp-13842	154	2	,	,	PUNCT
bjp-13842	154	3	a	a	DET
bjp-13842	154	4	recent	recent	ADJ
bjp-13842	154	5	observation	observation	NOUN
bjp-13842	154	6	from	from	ADP
bjp-13842	154	7	dioum	dioum	PROPN
bjp-13842	154	8	et	et	PROPN
bjp-13842	154	9	al	al	PROPN
bjp-13842	154	10	indicated	indicate	VERB
bjp-13842	154	11	that	that	SCONJ
bjp-13842	154	12	sirt1	sirt1	NOUN
bjp-13842	154	13	,	,	PUNCT
bjp-13842	154	14	a	a	DET
bjp-13842	154	15	class	class	NOUN
bjp-13842	154	16	iii	iii	PROPN
bjp-13842	154	17	hdac	hdac	PROPN
bjp-13842	154	18	,	,	PUNCT
bjp-13842	154	19	was	be	AUX
bjp-13842	154	20	implicated	implicate	VERB
bjp-13842	154	21	in	in	ADP
bjp-13842	154	22	the	the	DET
bjp-13842	154	23	regulation	regulation	NOUN
bjp-13842	154	24	of	of	ADP
bjp-13842	154	25	hif	hif	PROPN
bjp-13842	154	26	-2α	-2α	PUNCT
bjp-13842	154	27	signaling	signal	VERB
bjp-13842	154	28	,	,	PUNCT
bjp-13842	154	29	and	and	CCONJ
bjp-13842	154	30	hif-2α	hif-2α	NOUN
bjp-13842	154	31	acetylation	acetylation	NOUN
bjp-13842	154	32	was	be	AUX
bjp-13842	154	33	not	not	PART
bjp-13842	154	34	associated	associate	VERB
bjp-13842	154	35	with	with	ADP
bjp-13842	154	36	hif-2α	hif-2α	ADJ
bjp-13842	154	37	stability	stability	NOUN
bjp-13842	154	38	(	(	PUNCT
bjp-13842	154	39	dioum	dioum	X
bjp-13842	154	40	et	et	PROPN
bjp-13842	154	41	al	al	PROPN
bjp-13842	154	42	.	.	PROPN
bjp-13842	154	43	,	,	PUNCT
bjp-13842	154	44	2009	2009	NUM
bjp-13842	154	45	)	)	PUNCT
bjp-13842	154	46	.	.	PUNCT
bjp-13842	155	1	in	in	ADP
bjp-13842	155	2	previous	previous	ADJ
bjp-13842	155	3	studies	study	NOUN
bjp-13842	155	4	,	,	PUNCT
bjp-13842	155	5	hdac4	hdac4	NOUN
bjp-13842	155	6	and	and	CCONJ
bjp-13842	155	7	hdac6	hdac6	PROPN
bjp-13842	155	8	have	have	AUX
bjp-13842	155	9	been	be	AUX
bjp-13842	155	10	demonstrated	demonstrate	VERB
bjp-13842	155	11	to	to	PART
bjp-13842	155	12	be	be	AUX
bjp-13842	155	13	involved	involve	VERB
bjp-13842	155	14	in	in	ADP
bjp-13842	155	15	the	the	DET
bjp-13842	155	16	regulation	regulation	NOUN
bjp-13842	155	17	of	of	ADP
bjp-13842	155	18	hif1α	hif1α	PRON
bjp-13842	155	19	stability	stability	NOUN
bjp-13842	155	20	(	(	PUNCT
bjp-13842	155	21	qian	qian	PROPN
bjp-13842	155	22	et	et	PROPN
bjp-13842	155	23	al	al	PROPN
bjp-13842	155	24	.	.	PROPN
bjp-13842	155	25	,	,	PUNCT
bjp-13842	155	26	2006	2006	NUM
bjp-13842	155	27	;	;	PUNCT
bjp-13842	155	28	kong	kong	PROPN
bjp-13842	155	29	et	et	PROPN
bjp-13842	155	30	al	al	PROPN
bjp-13842	155	31	.	.	PROPN
bjp-13842	155	32	,	,	PUNCT
bjp-13842	155	33	2006	2006	NUM
bjp-13842	155	34	)	)	PUNCT
bjp-13842	155	35	.	.	PUNCT
bjp-13842	156	1	in	in	ADP
bjp-13842	156	2	the	the	DET
bjp-13842	156	3	present	present	ADJ
bjp-13842	156	4	study	study	NOUN
bjp-13842	156	5	,	,	PUNCT
bjp-13842	156	6	our	our	PRON
bjp-13842	156	7	findings	finding	NOUN
bjp-13842	156	8	revealed	reveal	VERB
bjp-13842	156	9	that	that	SCONJ
bjp-13842	156	10	hdac6	hdac6	PROPN
bjp-13842	156	11	was	be	AUX
bjp-13842	156	12	likely	likely	ADJ
bjp-13842	156	13	to	to	PART
bjp-13842	156	14	be	be	AUX
bjp-13842	156	15	implicated	implicate	VERB
bjp-13842	156	16	in	in	ADP
bjp-13842	156	17	the	the	DET
bjp-13842	156	18	regulation	regulation	NOUN
bjp-13842	156	19	of	of	ADP
bjp-13842	156	20	hif-2α	hif-2α	ADJ
bjp-13842	156	21	stability	stability	NOUN
bjp-13842	156	22	.	.	PUNCT
bjp-13842	157	1	hdac6	hdac6	PROPN
bjp-13842	157	2	has	have	AUX
bjp-13842	157	3	been	be	AUX
bjp-13842	157	4	linked	link	VERB
bjp-13842	157	5	to	to	ADP
bjp-13842	157	6	the	the	DET
bjp-13842	157	7	functions	function	NOUN
bjp-13842	157	8	of	of	ADP
bjp-13842	157	9	chaperon	chaperon	NOUN
bjp-13842	157	10	hsp90	hsp90	PROPN
bjp-13842	157	11	(	(	PUNCT
bjp-13842	157	12	chen	chen	PROPN
bjp-13842	157	13	and	and	CCONJ
bjp-13842	157	14	sang	sing	VERB
bjp-13842	157	15	,	,	PUNCT
bjp-13842	157	16	2011	2011	NUM
bjp-13842	157	17	)	)	PUNCT
bjp-13842	157	18	,	,	PUNCT
bjp-13842	157	19	and	and	CCONJ
bjp-13842	157	20	inhibition	inhibition	NOUN
bjp-13842	157	21	of	of	ADP
bjp-13842	157	22	hdac6	hdac6	NOUN
bjp-13842	157	23	may	may	AUX
bjp-13842	157	24	interfere	interfere	VERB
bjp-13842	157	25	with	with	ADP
bjp-13842	157	26	the	the	DET
bjp-13842	157	27	chaperon	chaperon	NOUN
bjp-13842	157	28	hsp90	hsp90	ADJ
bjp-13842	157	29	activity	activity	NOUN
bjp-13842	157	30	,	,	PUNCT
bjp-13842	157	31	leading	lead	VERB
bjp-13842	157	32	to	to	ADP
bjp-13842	157	33	the	the	DET
bjp-13842	157	34	degradation	degradation	NOUN
bjp-13842	157	35	of	of	ADP
bjp-13842	157	36	its	its	PRON
bjp-13842	157	37	client	client	NOUN
bjp-13842	157	38	proteins	protein	NOUN
bjp-13842	157	39	.	.	PUNCT
bjp-13842	158	1	therefore	therefore	ADV
bjp-13842	158	2	,	,	PUNCT
bjp-13842	158	3	more	more	ADJ
bjp-13842	158	4	work	work	NOUN
bjp-13842	158	5	is	be	AUX
bjp-13842	158	6	needed	need	VERB
bjp-13842	158	7	to	to	PART
bjp-13842	158	8	determine	determine	VERB
bjp-13842	158	9	the	the	DET
bjp-13842	158	10	role	role	NOUN
bjp-13842	158	11	of	of	ADP
bjp-13842	158	12	hsp90	hsp90	PROPN
bjp-13842	158	13	in	in	ADP
bjp-13842	158	14	tsa	tsa	NOUN
bjp-13842	158	15	induced	induce	VERB
bjp-13842	158	16	hif-2α	hif-2α	NOUN
bjp-13842	158	17	degradation	degradation	NOUN
bjp-13842	158	18	.	.	PUNCT
bjp-13842	159	1	in	in	ADP
bjp-13842	159	2	summary	summary	NOUN
bjp-13842	159	3	,	,	PUNCT
bjp-13842	159	4	our	our	PRON
bjp-13842	159	5	findings	finding	NOUN
bjp-13842	159	6	suggest	suggest	VERB
bjp-13842	159	7	that	that	SCONJ
bjp-13842	159	8	tsa	tsa	NOUN
bjp-13842	159	9	can	can	AUX
bjp-13842	159	10	destabilize	destabilize	VERB
bjp-13842	159	11	hif-2α	hif-2α	NOUN
bjp-13842	159	12	both	both	CCONJ
bjp-13842	159	13	in	in	ADP
bjp-13842	159	14	vitro	vitro	X
bjp-13842	159	15	and	and	CCONJ
bjp-13842	159	16	in	in	ADP
bjp-13842	159	17	vivo	vivo	NOUN
bjp-13842	159	18	,	,	PUNCT
bjp-13842	159	19	which	which	PRON
bjp-13842	159	20	is	be	AUX
bjp-13842	159	21	proteasome	proteasome	NOUN
bjp-13842	159	22	-	-	PUNCT
bjp-13842	159	23	dependent	dependent	ADJ
bjp-13842	159	24	,	,	PUNCT
bjp-13842	159	25	but	but	CCONJ
bjp-13842	159	26	vhl	vhl	PROPN
bjp-13842	159	27	independent	independent	NOUN
bjp-13842	159	28	.	.	PUNCT
bjp-13842	160	1	these	these	DET
bjp-13842	160	2	results	result	NOUN
bjp-13842	160	3	provide	provide	VERB
bjp-13842	160	4	a	a	DET
bjp-13842	160	5	new	new	ADJ
bjp-13842	160	6	insight	insight	NOUN
bjp-13842	160	7	into	into	ADP
bjp-13842	160	8	the	the	DET
bjp-13842	160	9	molecular	molecular	ADJ
bjp-13842	160	10	mechanism	mechanism	NOUN
bjp-13842	160	11	underlying	underlie	VERB
bjp-13842	160	12	the	the	DET
bjp-13842	160	13	anti	anti	ADJ
bjp-13842	160	14	-	-	ADJ
bjp-13842	160	15	cancer	cancer	ADJ
bjp-13842	160	16	effect	effect	NOUN
bjp-13842	160	17	of	of	ADP
bjp-13842	160	18	hdac	hdac	NOUN
bjp-13842	160	19	inhibitors	inhibitor	NOUN
bjp-13842	160	20	.	.	PUNCT
bjp-13842	161	1	contribution	contribution	NOUN
bjp-13842	161	2	drs	drs	PROPN
bjp-13842	161	3	.	.	PUNCT
bjp-13842	162	1	qingcheng	qingcheng	PROPN
bjp-13842	162	2	yang	yang	PROPN
bjp-13842	162	3	and	and	CCONJ
bjp-13842	162	4	yuzhen	yuzhen	PROPN
bjp-13842	162	5	du	du	PROPN
bjp-13842	162	6	contributed	contribute	VERB
bjp-13842	162	7	equally	equally	ADV
bjp-13842	162	8	in	in	ADP
bjp-13842	162	9	this	this	DET
bjp-13842	162	10	work	work	NOUN
bjp-13842	162	11	.	.	PUNCT
bjp-13842	163	1	acknowledgement	acknowledgement	NOUN
bjp-13842	163	2	this	this	DET
bjp-13842	163	3	work	work	NOUN
bjp-13842	163	4	was	be	AUX
bjp-13842	163	5	partially	partially	ADV
bjp-13842	163	6	supported	support	VERB
bjp-13842	163	7	by	by	ADP
bjp-13842	163	8	grant	grant	NOUN
bjp-13842	163	9	from	from	ADP
bjp-13842	163	10	chinese	chinese	ADJ
bjp-13842	163	11	natural	natural	ADJ
bjp-13842	163	12	science	science	PROPN
bjp-13842	163	13	foundation	foundation	NOUN
bjp-13842	163	14	(	(	PUNCT
bjp-13842	163	15	no	no	INTJ
bjp-13842	163	16	.	.	NOUN
bjp-13842	163	17	30973017	30973017	NUM
bjp-13842	163	18	to	to	ADP
bjp-13842	163	19	y.q	y.q	PROPN
bjp-13842	163	20	.	.	PUNCT
bjp-13842	163	21	)	)	PUNCT
bjp-13842	163	22	.	.	PUNCT
bjp-13842	164	1	references	reference	NOUN
bjp-13842	164	2	bertout	bertout	VERB
bjp-13842	164	3	ja	ja	PROPN
bjp-13842	164	4	,	,	PUNCT
bjp-13842	164	5	patel	patel	PROPN
bjp-13842	164	6	sa	sa	PROPN
bjp-13842	164	7	,	,	PUNCT
bjp-13842	164	8	simon	simon	PROPN
bjp-13842	164	9	mc	mc	PROPN
bjp-13842	164	10	.	.	PUNCT
bjp-13842	165	1	the	the	DET
bjp-13842	165	2	impact	impact	NOUN
bjp-13842	165	3	of	of	ADP
bjp-13842	165	4	oxygen	oxygen	NOUN
bjp-13842	165	5	availability	availability	NOUN
bjp-13842	165	6	on	on	ADP
bjp-13842	165	7	human	human	ADJ
bjp-13842	165	8	cancer	cancer	NOUN
bjp-13842	165	9	.	.	PUNCT
bjp-13842	166	1	nat	nat	PROPN
bjp-13842	166	2	rev	rev	PROPN
bjp-13842	166	3	cancer	cancer	NOUN
bjp-13842	166	4	.	.	PUNCT
bjp-13842	166	5	2008	2008	NUM
bjp-13842	166	6	;	;	PUNCT
bjp-13842	166	7	8	8	NUM
bjp-13842	166	8	:	:	SYM
bjp-13842	166	9	96775	96775	NUM
bjp-13842	166	10	.	.	PUNCT
bjp-13842	167	1	blander	bland	ADJ
bjp-13842	167	2	g	g	NOUN
bjp-13842	167	3	,	,	PUNCT
bjp-13842	167	4	guarente	guarente	PROPN
bjp-13842	167	5	l.	l.	PROPN
bjp-13842	167	6	the	the	DET
bjp-13842	167	7	sir2	sir2	PROPN
bjp-13842	167	8	family	family	NOUN
bjp-13842	167	9	of	of	ADP
bjp-13842	167	10	protein	protein	NOUN
bjp-13842	167	11	deacetylases	deacetylase	NOUN
bjp-13842	167	12	.	.	PUNCT
bjp-13842	168	1	annu	annu	PROPN
bjp-13842	168	2	rev	rev	VERB
bjp-13842	168	3	biochem	biochem	PROPN
bjp-13842	168	4	.	.	PUNCT
bjp-13842	169	1	2004	2004	NUM
bjp-13842	169	2	;	;	PUNCT
bjp-13842	169	3	73	73	NUM
bjp-13842	169	4	:	:	PUNCT
bjp-13842	169	5	417	417	NUM
bjp-13842	169	6	-	-	SYM
bjp-13842	169	7	35	35	NUM
bjp-13842	169	8	.	.	PUNCT
bjp-13842	170	1	carmeliet	carmeliet	PROPN
bjp-13842	170	2	p.	p.	NOUN
bjp-13842	170	3	mechanisms	mechanism	NOUN
bjp-13842	170	4	of	of	ADP
bjp-13842	170	5	angiogenesis	angiogenesis	NOUN
bjp-13842	170	6	and	and	CCONJ
bjp-13842	170	7	arteriogenesis	arteriogenesis	NOUN
bjp-13842	170	8	.	.	PUNCT
bjp-13842	171	1	nature	nature	PROPN
bjp-13842	171	2	med	me	VERB
bjp-13842	171	3	.	.	PROPN
bjp-13842	171	4	2000	2000	NUM
bjp-13842	171	5	;	;	PUNCT
bjp-13842	172	1	6	6	NUM
bjp-13842	172	2	:	:	SYM
bjp-13842	172	3	389	389	NUM
bjp-13842	172	4	-	-	SYM
bjp-13842	172	5	95	95	NUM
bjp-13842	172	6	.	.	PUNCT
bjp-13842	173	1	caro	caro	PROPN
bjp-13842	173	2	j.	j.	PROPN
bjp-13842	173	3	hypoxia	hypoxia	PROPN
bjp-13842	173	4	regulation	regulation	NOUN
bjp-13842	173	5	of	of	ADP
bjp-13842	173	6	gene	gene	NOUN
bjp-13842	173	7	transcription	transcription	NOUN
bjp-13842	173	8	.	.	PUNCT
bjp-13842	174	1	high	high	ADJ
bjp-13842	174	2	alt	alt	VERB
bjp-13842	174	3	med	med	ADJ
bjp-13842	174	4	biol	biol	PROPN
bjp-13842	174	5	.	.	PUNCT
bjp-13842	175	1	2001	2001	NUM
bjp-13842	175	2	;	;	PUNCT
bjp-13842	175	3	2	2	NUM
bjp-13842	175	4	:	:	SYM
bjp-13842	175	5	145	145	NUM
bjp-13842	175	6	-	-	SYM
bjp-13842	175	7	54	54	NUM
bjp-13842	175	8	.	.	PUNCT
bjp-13842	176	1	chen	chen	PROPN
bjp-13842	176	2	s	s	PROPN
bjp-13842	176	3	,	,	PUNCT
bjp-13842	176	4	sang	sing	VERB
bjp-13842	176	5	n.	n.	PROPN
bjp-13842	176	6	histone	histone	PROPN
bjp-13842	176	7	deacetylase	deacetylase	VERB
bjp-13842	176	8	inhibitors	inhibitor	NOUN
bjp-13842	176	9	:	:	PUNCT
bjp-13842	176	10	the	the	DET
bjp-13842	176	11	epigenetic	epigenetic	ADJ
bjp-13842	176	12	therapeutics	therapeutic	NOUN
bjp-13842	176	13	that	that	PRON
bjp-13842	176	14	repress	repress	VERB
bjp-13842	176	15	hypoxia	hypoxia	NOUN
bjp-13842	176	16	-	-	PUNCT
bjp-13842	176	17	inducible	inducible	ADJ
bjp-13842	176	18	factors	factor	NOUN
bjp-13842	176	19	.	.	PUNCT
bjp-13842	177	1	j	j	PROPN
bjp-13842	177	2	biomed	biome	VERB
bjp-13842	177	3	biotechnol	biotechnol	NOUN
bjp-13842	177	4	.	.	PUNCT
bjp-13842	178	1	2011	2011	NUM
bjp-13842	178	2	;	;	PUNCT
bjp-13842	178	3	2011	2011	NUM
bjp-13842	178	4	:	:	PUNCT
bjp-13842	178	5	197946	197946	NUM
bjp-13842	178	6	.	.	PUNCT
bjp-13842	179	1	de	de	PROPN
bjp-13842	179	2	ruijter	ruijter	PROPN
bjp-13842	179	3	aj	aj	PROPN
bjp-13842	179	4	,	,	PUNCT
bjp-13842	179	5	van	van	PROPN
bjp-13842	179	6	gennip	gennip	PROPN
bjp-13842	179	7	ah	ah	INTJ
bjp-13842	179	8	,	,	PUNCT
bjp-13842	179	9	caron	caron	PROPN
bjp-13842	179	10	hn	hn	PROPN
bjp-13842	179	11	,	,	PUNCT
bjp-13842	179	12	kemp	kemp	PROPN
bjp-13842	179	13	s	s	PROPN
bjp-13842	179	14	,	,	PUNCT
bjp-13842	179	15	van	van	PROPN
bjp-13842	179	16	figure	figure	NOUN
bjp-13842	179	17	4	4	NUM
bjp-13842	179	18	:	:	PUNCT
bjp-13842	179	19	hdac6	hdac6	PROPN
bjp-13842	179	20	is	be	AUX
bjp-13842	179	21	involved	involve	VERB
bjp-13842	179	22	in	in	ADP
bjp-13842	179	23	regulation	regulation	NOUN
bjp-13842	179	24	of	of	ADP
bjp-13842	179	25	hif-2α	hif-2α	NOUN
bjp-13842	179	26	degradation	degradation	NOUN
bjp-13842	179	27	and	and	CCONJ
bjp-13842	179	28	hif-2α	hif-2α	NOUN
bjp-13842	179	29	is	be	AUX
bjp-13842	179	30	acetylated	acetylate	VERB
bjp-13842	179	31	by	by	ADP
bjp-13842	179	32	tsa	tsa	NOUN
bjp-13842	179	33	(	(	PUNCT
bjp-13842	179	34	a	a	NOUN
bjp-13842	179	35	)	)	PUNCT
bjp-13842	179	36	sirna	sirna	PROPN
bjp-13842	179	37	against	against	ADP
bjp-13842	179	38	hdac6	hdac6	PROPN
bjp-13842	179	39	and	and	CCONJ
bjp-13842	179	40	control	control	PROPN
bjp-13842	179	41	sirna	sirna	PROPN
bjp-13842	179	42	were	be	AUX
bjp-13842	179	43	transfected	transfecte	VERB
bjp-13842	179	44	into	into	ADP
bjp-13842	179	45	mg-63	mg-63	NOUN
bjp-13842	179	46	cells	cell	NOUN
bjp-13842	179	47	at	at	ADP
bjp-13842	179	48	50	50	NUM
bjp-13842	179	49	nm	nm	NOUN
bjp-13842	179	50	.	.	PUNCT
bjp-13842	180	1	at	at	ADP
bjp-13842	180	2	48	48	NUM
bjp-13842	180	3	and	and	CCONJ
bjp-13842	180	4	72	72	NUM
bjp-13842	180	5	hours	hour	NOUN
bjp-13842	180	6	after	after	ADP
bjp-13842	180	7	transfection	transfection	NOUN
bjp-13842	180	8	,	,	PUNCT
bjp-13842	180	9	cells	cell	NOUN
bjp-13842	180	10	were	be	AUX
bjp-13842	180	11	exposed	expose	VERB
bjp-13842	180	12	to	to	ADP
bjp-13842	180	13	hypoxia	hypoxia	NOUN
bjp-13842	180	14	for	for	ADP
bjp-13842	180	15	8	8	NUM
bjp-13842	180	16	hours	hour	NOUN
bjp-13842	180	17	,	,	PUNCT
bjp-13842	180	18	and	and	CCONJ
bjp-13842	180	19	cell	cell	NOUN
bjp-13842	180	20	extracts	extract	NOUN
bjp-13842	180	21	were	be	AUX
bjp-13842	180	22	subjected	subject	VERB
bjp-13842	180	23	to	to	ADP
bjp-13842	180	24	western	western	ADJ
bjp-13842	180	25	blot	blot	NOUN
bjp-13842	180	26	assay	assay	VERB
bjp-13842	180	27	for	for	ADP
bjp-13842	180	28	hif-2α	hif-2α	NOUN
bjp-13842	180	29	,	,	PUNCT
bjp-13842	180	30	hdac6	hdac6	PROPN
bjp-13842	180	31	and	and	CCONJ
bjp-13842	180	32	tubulin	tubulin	NOUN
bjp-13842	180	33	.	.	PUNCT
bjp-13842	181	1	(	(	PUNCT
bjp-13842	181	2	b	b	X
bjp-13842	181	3	)	)	PUNCT
bjp-13842	181	4	mg-63	mg-63	NOUN
bjp-13842	181	5	cells	cell	NOUN
bjp-13842	181	6	were	be	AUX
bjp-13842	181	7	treated	treat	VERB
bjp-13842	181	8	for	for	ADP
bjp-13842	181	9	8	8	NUM
bjp-13842	181	10	hours	hour	NOUN
bjp-13842	181	11	in	in	ADP
bjp-13842	181	12	hypoxia	hypoxia	NOUN
bjp-13842	181	13	(	(	PUNCT
bjp-13842	181	14	1%o2	1%o2	NUM
bjp-13842	181	15	)	)	PUNCT
bjp-13842	181	16	,	,	PUNCT
bjp-13842	181	17	and	and	CCONJ
bjp-13842	181	18	cell	cell	NOUN
bjp-13842	181	19	extracts	extract	NOUN
bjp-13842	181	20	were	be	AUX
bjp-13842	181	21	immunoprecipitated	immunoprecipitate	VERB
bjp-13842	181	22	with	with	ADP
bjp-13842	181	23	antibody	antibody	NOUN
bjp-13842	181	24	against	against	ADP
bjp-13842	181	25	either	either	DET
bjp-13842	181	26	hdac6	hdac6	PROPN
bjp-13842	181	27	or	or	CCONJ
bjp-13842	181	28	control	control	PROPN
bjp-13842	181	29	igg	igg	PROPN
bjp-13842	181	30	.	.	PUNCT
bjp-13842	182	1	the	the	DET
bjp-13842	182	2	immunocomplexes	immunocomplexe	NOUN
bjp-13842	182	3	were	be	AUX
bjp-13842	182	4	detected	detect	VERB
bjp-13842	182	5	for	for	ADP
bjp-13842	182	6	hdac6	hdac6	PROPN
bjp-13842	182	7	and	and	CCONJ
bjp-13842	182	8	hif-2α	hif-2α	NOUN
bjp-13842	182	9	by	by	ADP
bjp-13842	182	10	western	western	ADJ
bjp-13842	182	11	blot	blot	NOUN
bjp-13842	182	12	assay	assay	VERB
bjp-13842	182	13	,	,	PUNCT
bjp-13842	182	14	and	and	CCONJ
bjp-13842	182	15	20	20	NUM
bjp-13842	182	16	µg	µg	NOUN
bjp-13842	182	17	of	of	ADP
bjp-13842	182	18	cell	cell	NOUN
bjp-13842	182	19	extracts	extract	NOUN
bjp-13842	182	20	without	without	ADP
bjp-13842	182	21	immunoprecipitation	immunoprecipitation	NOUN
bjp-13842	182	22	served	serve	VERB
bjp-13842	182	23	as	as	ADP
bjp-13842	182	24	a	a	DET
bjp-13842	182	25	control	control	NOUN
bjp-13842	182	26	.	.	PUNCT
bjp-13842	183	1	(	(	PUNCT
bjp-13842	183	2	c	c	X
bjp-13842	183	3	)	)	PUNCT
bjp-13842	183	4	mg-63	mg-63	NOUN
bjp-13842	183	5	cells	cell	NOUN
bjp-13842	183	6	were	be	AUX
bjp-13842	183	7	exposed	expose	VERB
bjp-13842	183	8	to	to	ADP
bjp-13842	183	9	hypoxia	hypoxia	NOUN
bjp-13842	183	10	(	(	PUNCT
bjp-13842	183	11	1%o2	1%o2	NUM
bjp-13842	183	12	)	)	PUNCT
bjp-13842	183	13	and	and	CCONJ
bjp-13842	183	14	mg132	mg132	PROPN
bjp-13842	183	15	(	(	PUNCT
bjp-13842	183	16	5	5	NUM
bjp-13842	183	17	μm	μm	NUM
bjp-13842	183	18	)	)	PUNCT
bjp-13842	183	19	for	for	ADP
bjp-13842	183	20	6	6	NUM
bjp-13842	183	21	hours	hour	NOUN
bjp-13842	183	22	with	with	ADP
bjp-13842	183	23	or	or	CCONJ
bjp-13842	183	24	without	without	ADP
bjp-13842	183	25	600	600	NUM
bjp-13842	183	26	nm	nm	NOUN
bjp-13842	183	27	tsa	tsa	NOUN
bjp-13842	183	28	,	,	PUNCT
bjp-13842	183	29	and	and	CCONJ
bjp-13842	183	30	cell	cell	NOUN
bjp-13842	183	31	lysates	lysate	NOUN
bjp-13842	183	32	were	be	AUX
bjp-13842	183	33	immunoprecipitated	immunoprecipitate	VERB
bjp-13842	183	34	with	with	ADP
bjp-13842	183	35	anti	anti	ADJ
bjp-13842	183	36	-	-	ADJ
bjp-13842	183	37	hif2α	hif2α	ADJ
bjp-13842	183	38	antibody	antibody	NOUN
bjp-13842	183	39	.	.	PUNCT
bjp-13842	184	1	cell	cell	NOUN
bjp-13842	184	2	lysates	lysate	NOUN
bjp-13842	184	3	and	and	CCONJ
bjp-13842	184	4	immunocomplexes	immunocomplexe	NOUN
bjp-13842	184	5	were	be	AUX
bjp-13842	184	6	immunoblotted	immunoblotte	VERB
bjp-13842	184	7	with	with	ADP
bjp-13842	184	8	anti	anti	ADJ
bjp-13842	184	9	-	-	ADJ
bjp-13842	184	10	hif-2α	hif-2α	ADJ
bjp-13842	184	11	and	and	CCONJ
bjp-13842	184	12	antiacetyl	antiacetyl	NOUN
bjp-13842	184	13	-	-	PUNCT
bjp-13842	184	14	lysine	lysine	NOUN
bjp-13842	184	15	(	(	PUNCT
bjp-13842	184	16	a	a	DET
bjp-13842	184	17	-	-	PUNCT
bjp-13842	184	18	aclys	aclys	ADJ
bjp-13842	184	19	)	)	PUNCT
bjp-13842	184	20	antibodies	antibodie	VERB
bjp-13842	184	21	bangladesh	bangladesh	PROPN
bjp-13842	184	22	j	j	PROPN
bjp-13842	184	23	pharmacol	pharmacol	PROPN
bjp-13842	184	24	2013	2013	NUM
bjp-13842	184	25	;	;	PUNCT
bjp-13842	184	26	8	8	NUM
bjp-13842	184	27	:	:	SYM
bjp-13842	184	28	142	142	NUM
bjp-13842	184	29	-	-	SYM
bjp-13842	184	30	148	148	NUM
bjp-13842	184	31	147	147	NUM
bjp-13842	184	32	author	author	NOUN
bjp-13842	184	33	info	info	NOUN
bjp-13842	184	34	qingcheng	qingcheng	PROPN
bjp-13842	184	35	yang	yang	PROPN
bjp-13842	184	36	(	(	PUNCT
bjp-13842	184	37	principal	principal	ADJ
bjp-13842	184	38	contact	contact	NOUN
bjp-13842	184	39	)	)	PUNCT
bjp-13842	185	1	e	e	NOUN
bjp-13842	185	2	-	-	NOUN
bjp-13842	185	3	mail	mail	NOUN
bjp-13842	185	4	:	:	PUNCT
bjp-13842	185	5	tjyqc@163.com	tjyqc@163.com	X
bjp-13842	185	6	kuilenburg	kuilenburg	PROPN
bjp-13842	185	7	ab	ab	PROPN
bjp-13842	185	8	.	.	PUNCT
bjp-13842	186	1	histone	histone	NOUN
bjp-13842	186	2	deacetylases	deacetylase	NOUN
bjp-13842	186	3	(	(	PUNCT
bjp-13842	186	4	hdacs	hdac	NOUN
bjp-13842	186	5	):	):	PUNCT
bjp-13842	186	6	characterization	characterization	NOUN
bjp-13842	186	7	of	of	ADP
bjp-13842	186	8	the	the	DET
bjp-13842	186	9	classical	classical	ADJ
bjp-13842	186	10	hdac	hdac	NOUN
bjp-13842	186	11	family	family	NOUN
bjp-13842	186	12	.	.	PUNCT
bjp-13842	187	1	biochem	biochem	PROPN
bjp-13842	187	2	j.	j.	PROPN
bjp-13842	187	3	2003	2003	NUM
bjp-13842	187	4	;	;	PUNCT
bjp-13842	187	5	370	370	NUM
bjp-13842	187	6	:	:	PUNCT
bjp-13842	187	7	737	737	NUM
bjp-13842	187	8	-	-	SYM
bjp-13842	187	9	49	49	NUM
bjp-13842	187	10	.	.	PUNCT
bjp-13842	188	1	dioum	dioum	VERB
bjp-13842	188	2	em	em	PRON
bjp-13842	188	3	,	,	PUNCT
bjp-13842	188	4	chen	chen	PROPN
bjp-13842	188	5	r	r	PROPN
bjp-13842	188	6	,	,	PUNCT
bjp-13842	188	7	alexander	alexander	PROPN
bjp-13842	188	8	ms	ms	PROPN
bjp-13842	188	9	,	,	PUNCT
bjp-13842	188	10	zhang	zhang	PROPN
bjp-13842	188	11	q	q	PROPN
bjp-13842	188	12	,	,	PUNCT
bjp-13842	188	13	hogg	hogg	PROPN
bjp-13842	188	14	rt	rt	PROPN
bjp-13842	188	15	,	,	PUNCT
bjp-13842	188	16	gerard	gerard	PROPN
bjp-13842	188	17	rd	rd	PROPN
bjp-13842	188	18	,	,	PUNCT
bjp-13842	189	1	garcia	garcia	PROPN
bjp-13842	189	2	ja	ja	PROPN
bjp-13842	189	3	.	.	PUNCT
bjp-13842	189	4	regulation	regulation	NOUN
bjp-13842	189	5	of	of	ADP
bjp-13842	189	6	hypoxia	hypoxia	NOUN
bjp-13842	189	7	-	-	PUNCT
bjp-13842	189	8	inducible	inducible	ADJ
bjp-13842	189	9	factor	factor	NOUN
bjp-13842	189	10	2alpha	2alpha	NUM
bjp-13842	189	11	signaling	signal	VERB
bjp-13842	189	12	by	by	ADP
bjp-13842	189	13	the	the	DET
bjp-13842	189	14	stress	stress	NOUN
bjp-13842	189	15	-	-	PUNCT
bjp-13842	189	16	responsive	responsive	ADJ
bjp-13842	189	17	deacetylase	deacetylase	NOUN
bjp-13842	189	18	sirtuin	sirtuin	NOUN
bjp-13842	189	19	1	1	NUM
bjp-13842	189	20	.	.	PUNCT
bjp-13842	190	1	science	science	NOUN
bjp-13842	190	2	.	.	PUNCT
bjp-13842	191	1	2009	2009	NUM
bjp-13842	191	2	;	;	PUNCT
bjp-13842	191	3	324	324	NUM
bjp-13842	191	4	:	:	PUNCT
bjp-13842	191	5	1289	1289	NUM
bjp-13842	191	6	-	-	SYM
bjp-13842	191	7	93	93	NUM
bjp-13842	191	8	.	.	PUNCT
bjp-13842	192	1	evans	evans	PROPN
bjp-13842	192	2	sm	sm	PROPN
bjp-13842	192	3	,	,	PUNCT
bjp-13842	192	4	koch	koch	PROPN
bjp-13842	192	5	cj	cj	PROPN
bjp-13842	192	6	.	.	PUNCT
bjp-13842	193	1	prognostic	prognostic	ADJ
bjp-13842	193	2	significance	significance	NOUN
bjp-13842	193	3	of	of	ADP
bjp-13842	193	4	tumor	tumor	NOUN
bjp-13842	193	5	oxygenation	oxygenation	NOUN
bjp-13842	193	6	in	in	ADP
bjp-13842	193	7	humans	human	NOUN
bjp-13842	193	8	.	.	PUNCT
bjp-13842	194	1	cancer	cancer	PROPN
bjp-13842	194	2	lett	lett	PROPN
bjp-13842	194	3	.	.	PUNCT
bjp-13842	195	1	2003	2003	NUM
bjp-13842	195	2	;	;	PUNCT
bjp-13842	195	3	195	195	NUM
bjp-13842	195	4	:	:	SYM
bjp-13842	195	5	1	1	NUM
bjp-13842	195	6	-	-	SYM
bjp-13842	195	7	16	16	NUM
bjp-13842	195	8	.	.	PUNCT
bjp-13842	196	1	fath	fath	PROPN
bjp-13842	196	2	dm	dm	PROPN
bjp-13842	196	3	,	,	PUNCT
bjp-13842	196	4	kong	kong	PROPN
bjp-13842	196	5	x	x	PROPN
bjp-13842	196	6	,	,	PUNCT
bjp-13842	196	7	liang	liang	PROPN
bjp-13842	196	8	d	d	PROPN
bjp-13842	196	9	,	,	PUNCT
bjp-13842	196	10	lin	lin	PROPN
bjp-13842	196	11	z	z	PROPN
bjp-13842	196	12	,	,	PUNCT
bjp-13842	196	13	chou	chou	PROPN
bjp-13842	196	14	a	a	PROPN
bjp-13842	196	15	,	,	PUNCT
bjp-13842	196	16	jiang	jiang	PROPN
bjp-13842	196	17	y	y	PROPN
bjp-13842	196	18	,	,	PUNCT
bjp-13842	196	19	fang	fang	PROPN
bjp-13842	196	20	j	j	PROPN
bjp-13842	196	21	,	,	PUNCT
bjp-13842	196	22	caro	caro	PROPN
bjp-13842	196	23	j	j	PROPN
bjp-13842	196	24	,	,	PUNCT
bjp-13842	196	25	sang	sing	VERB
bjp-13842	196	26	n.	n.	PROPN
bjp-13842	196	27	histone	histone	PROPN
bjp-13842	196	28	deacetylase	deacetylase	VERB
bjp-13842	196	29	inhibitors	inhibitor	NOUN
bjp-13842	196	30	repress	repress	VERB
bjp-13842	196	31	the	the	DET
bjp-13842	196	32	transactivation	transactivation	NOUN
bjp-13842	196	33	potential	potential	NOUN
bjp-13842	196	34	of	of	ADP
bjp-13842	196	35	hypoxia	hypoxia	NOUN
bjp-13842	196	36	-	-	PUNCT
bjp-13842	196	37	inducible	inducible	ADJ
bjp-13842	196	38	factors	factor	NOUN
bjp-13842	196	39	independently	independently	ADV
bjp-13842	196	40	of	of	ADP
bjp-13842	196	41	direct	direct	ADJ
bjp-13842	196	42	acetylation	acetylation	NOUN
bjp-13842	196	43	of	of	ADP
bjp-13842	196	44	hif	hif	PROPN
bjp-13842	196	45	-	-	PUNCT
bjp-13842	196	46	alpha	alpha	NOUN
bjp-13842	196	47	.	.	PUNCT
bjp-13842	197	1	j	j	PROPN
bjp-13842	197	2	biol	biol	PROPN
bjp-13842	197	3	chem	chem	NOUN
bjp-13842	197	4	.	.	PUNCT
bjp-13842	198	1	2006	2006	NUM
bjp-13842	198	2	;	;	PUNCT
bjp-13842	198	3	281	281	NUM
bjp-13842	198	4	:	:	PUNCT
bjp-13842	198	5	13612	13612	NUM
bjp-13842	198	6	-	-	SYM
bjp-13842	198	7	19	19	NUM
bjp-13842	198	8	.	.	PUNCT
bjp-13842	198	9	fraisi	fraisi	PROPN
bjp-13842	198	10	p	p	NOUN
bjp-13842	198	11	,	,	PUNCT
bjp-13842	198	12	mazzone	mazzone	NOUN
bjp-13842	198	13	m	m	PROPN
bjp-13842	198	14	,	,	PUNCT
bjp-13842	198	15	schmidt	schmidt	PROPN
bjp-13842	198	16	t	t	PROPN
bjp-13842	198	17	,	,	PUNCT
bjp-13842	198	18	carmeliet	carmeliet	PROPN
bjp-13842	198	19	p.	p.	NOUN
bjp-13842	198	20	regulation	regulation	NOUN
bjp-13842	198	21	of	of	ADP
bjp-13842	198	22	angiogenesis	angiogenesis	NOUN
bjp-13842	198	23	by	by	ADP
bjp-13842	198	24	oxygen	oxygen	NOUN
bjp-13842	198	25	and	and	CCONJ
bjp-13842	198	26	metabolism	metabolism	NOUN
bjp-13842	198	27	.	.	PUNCT
bjp-13842	199	1	dev	dev	NOUN
bjp-13842	199	2	cell	cell	NOUN
bjp-13842	199	3	.	.	PUNCT
bjp-13842	200	1	2009	2009	NUM
bjp-13842	200	2	;	;	PUNCT
bjp-13842	200	3	16	16	NUM
bjp-13842	200	4	:	:	SYM
bjp-13842	200	5	97	97	NUM
bjp-13842	200	6	-	-	SYM
bjp-13842	200	7	106	106	NUM
bjp-13842	200	8	.	.	PUNCT
bjp-13842	201	1	glozak	glozak	PROPN
bjp-13842	201	2	ma	ma	PROPN
bjp-13842	201	3	,	,	PUNCT
bjp-13842	201	4	sengupta	sengupta	PROPN
bjp-13842	201	5	n	n	CCONJ
bjp-13842	201	6	,	,	PUNCT
bjp-13842	201	7	zhang	zhang	PROPN
bjp-13842	201	8	x	x	PROPN
bjp-13842	201	9	,	,	PUNCT
bjp-13842	201	10	seto	seto	PROPN
bjp-13842	201	11	e.	e.	PROPN
bjp-13842	201	12	acetylation	acetylation	NOUN
bjp-13842	201	13	and	and	CCONJ
bjp-13842	201	14	deacetylation	deacetylation	NOUN
bjp-13842	201	15	of	of	ADP
bjp-13842	201	16	non	non	ADJ
bjp-13842	201	17	-	-	ADJ
bjp-13842	201	18	histone	histone	ADJ
bjp-13842	201	19	proteins	protein	NOUN
bjp-13842	201	20	.	.	PUNCT
bjp-13842	202	1	gene	gene	NOUN
bjp-13842	202	2	2005	2005	NUM
bjp-13842	202	3	;	;	PUNCT
bjp-13842	202	4	363	363	NUM
bjp-13842	202	5	:	:	SYM
bjp-13842	202	6	15	15	NUM
bjp-13842	202	7	-	-	SYM
bjp-13842	202	8	23	23	NUM
bjp-13842	202	9	.	.	PUNCT
bjp-13842	203	1	hockel	hockel	PROPN
bjp-13842	203	2	m	m	PROPN
bjp-13842	203	3	,	,	PUNCT
bjp-13842	203	4	vaupel	vaupel	NOUN
bjp-13842	203	5	p.	p.	NOUN
bjp-13842	203	6	biological	biological	ADJ
bjp-13842	203	7	consequences	consequence	NOUN
bjp-13842	203	8	of	of	ADP
bjp-13842	203	9	tumor	tumor	NOUN
bjp-13842	203	10	hypoxia	hypoxia	NOUN
bjp-13842	203	11	.	.	PUNCT
bjp-13842	204	1	semin	semin	PROPN
bjp-13842	204	2	oncol	oncol	PROPN
bjp-13842	204	3	.	.	PUNCT
bjp-13842	205	1	2001	2001	NUM
bjp-13842	205	2	;	;	PUNCT
bjp-13842	205	3	28	28	NUM
bjp-13842	205	4	:	:	SYM
bjp-13842	205	5	36	36	NUM
bjp-13842	205	6	-	-	SYM
bjp-13842	205	7	41	41	NUM
bjp-13842	205	8	.	.	PUNCT
bjp-13842	206	1	holmquist	holmquist	NOUN
bjp-13842	206	2	-	-	PUNCT
bjp-13842	206	3	mengelbier	mengelbier	NOUN
bjp-13842	206	4	l	l	NOUN
bjp-13842	206	5	,	,	PUNCT
bjp-13842	206	6	fredlund	fredlund	PROPN
bjp-13842	206	7	e	e	NOUN
bjp-13842	206	8	,	,	PUNCT
bjp-13842	206	9	lofstedt	lofstedt	PROPN
bjp-13842	206	10	t	t	PROPN
bjp-13842	206	11	,	,	PUNCT
bjp-13842	206	12	noguera	noguera	NOUN
bjp-13842	206	13	r	r	NOUN
bjp-13842	206	14	,	,	PUNCT
bjp-13842	206	15	navarro	navarro	PROPN
bjp-13842	206	16	s	s	PROPN
bjp-13842	206	17	,	,	PUNCT
bjp-13842	206	18	nilsson	nilsson	PROPN
bjp-13842	206	19	h.	h.	PROPN
bjp-13842	206	20	recruitment	recruitment	PROPN
bjp-13842	206	21	of	of	ADP
bjp-13842	206	22	hif-1alpha	hif-1alpha	NOUN
bjp-13842	206	23	and	and	CCONJ
bjp-13842	206	24	hif2alpha	hif2alpha	PROPN
bjp-13842	206	25	to	to	ADP
bjp-13842	206	26	common	common	ADJ
bjp-13842	206	27	target	target	NOUN
bjp-13842	206	28	genes	gene	NOUN
bjp-13842	206	29	is	be	AUX
bjp-13842	206	30	differentially	differentially	ADV
bjp-13842	206	31	regulated	regulate	VERB
bjp-13842	206	32	in	in	ADP
bjp-13842	206	33	neuroblastoma	neuroblastoma	NOUN
bjp-13842	206	34	:	:	PUNCT
bjp-13842	206	35	hif-2alpha	hif-2alpha	X
bjp-13842	206	36	promotes	promote	VERB
bjp-13842	206	37	an	an	DET
bjp-13842	206	38	aggressive	aggressive	ADJ
bjp-13842	206	39	phenotype	phenotype	NOUN
bjp-13842	206	40	.	.	PUNCT
bjp-13842	207	1	cancer	cancer	NOUN
bjp-13842	207	2	cell	cell	NOUN
bjp-13842	207	3	.	.	PUNCT
bjp-13842	208	1	2006	2006	NUM
bjp-13842	208	2	;	;	PUNCT
bjp-13842	208	3	10	10	NUM
bjp-13842	208	4	:	:	SYM
bjp-13842	208	5	413	413	NUM
bjp-13842	208	6	-	-	SYM
bjp-13842	208	7	23	23	NUM
bjp-13842	208	8	.	.	PUNCT
bjp-13842	209	1	kim	kim	PROPN
bjp-13842	209	2	hj	hj	PROPN
bjp-13842	209	3	,	,	PUNCT
bjp-13842	209	4	bae	bae	PROPN
bjp-13842	209	5	sc	sc	PROPN
bjp-13842	209	6	.	.	PUNCT
bjp-13842	210	1	histone	histone	NOUN
bjp-13842	210	2	deacetylase	deacetylase	VERB
bjp-13842	210	3	inhibitors	inhibitor	NOUN
bjp-13842	210	4	:	:	PUNCT
bjp-13842	210	5	molecular	molecular	ADJ
bjp-13842	210	6	mechanisms	mechanism	NOUN
bjp-13842	210	7	of	of	ADP
bjp-13842	210	8	action	action	NOUN
bjp-13842	210	9	and	and	CCONJ
bjp-13842	210	10	clinical	clinical	ADJ
bjp-13842	210	11	trials	trial	NOUN
bjp-13842	210	12	as	as	ADP
bjp-13842	210	13	anti	anti	ADJ
bjp-13842	210	14	-	-	ADJ
bjp-13842	210	15	cancer	cancer	ADJ
bjp-13842	210	16	drugs	drug	NOUN
bjp-13842	210	17	.	.	PUNCT
bjp-13842	211	1	am	be	AUX
bjp-13842	211	2	j	j	PROPN
bjp-13842	211	3	transl	transl	PROPN
bjp-13842	211	4	res	re	NOUN
bjp-13842	211	5	.	.	PUNCT
bjp-13842	212	1	2011	2011	NUM
bjp-13842	212	2	;	;	PUNCT
bjp-13842	212	3	3	3	NUM
bjp-13842	212	4	:	:	SYM
bjp-13842	212	5	166	166	NUM
bjp-13842	212	6	-	-	SYM
bjp-13842	212	7	79	79	NUM
bjp-13842	212	8	.	.	PUNCT
bjp-13842	213	1	kim	kim	PROPN
bjp-13842	213	2	ms	ms	PROPN
bjp-13842	213	3	,	,	PUNCT
bjp-13842	213	4	kwon	kwon	PROPN
bjp-13842	213	5	hj	hj	PROPN
bjp-13842	213	6	,	,	PUNCT
bjp-13842	213	7	lee	lee	PROPN
bjp-13842	213	8	ym	ym	PROPN
bjp-13842	213	9	,	,	PUNCT
bjp-13842	213	10	baek	baek	PROPN
bjp-13842	213	11	jh	jh	PROPN
bjp-13842	213	12	,	,	PUNCT
bjp-13842	213	13	jang	jang	PROPN
bjp-13842	213	14	je	je	PROPN
bjp-13842	213	15	,	,	PUNCT
bjp-13842	213	16	lee	lee	PROPN
bjp-13842	213	17	sw	sw	PROPN
bjp-13842	213	18	,	,	PUNCT
bjp-13842	213	19	moon	moon	PROPN
bjp-13842	213	20	ej	ej	PROPN
bjp-13842	213	21	,	,	PUNCT
bjp-13842	213	22	kim	kim	PROPN
bjp-13842	213	23	hs	hs	PROPN
bjp-13842	213	24	,	,	PUNCT
bjp-13842	213	25	lee	lee	PROPN
bjp-13842	213	26	sk	sk	PROPN
bjp-13842	213	27	,	,	PUNCT
bjp-13842	213	28	chung	chung	PROPN
bjp-13842	213	29	hy	hy	PROPN
bjp-13842	213	30	,	,	PUNCT
bjp-13842	213	31	kim	kim	PROPN
bjp-13842	213	32	cw	cw	PROPN
bjp-13842	213	33	,	,	PUNCT
bjp-13842	213	34	kim	kim	PROPN
bjp-13842	213	35	kw	kw	PROPN
bjp-13842	213	36	.	.	PUNCT
bjp-13842	214	1	histone	histone	NOUN
bjp-13842	214	2	deacetylases	deacetylase	NOUN
bjp-13842	214	3	induce	induce	VERB
bjp-13842	214	4	angiogenesis	angiogenesis	NOUN
bjp-13842	214	5	by	by	ADP
bjp-13842	214	6	negative	negative	ADJ
bjp-13842	214	7	regulation	regulation	NOUN
bjp-13842	214	8	of	of	ADP
bjp-13842	214	9	tumor	tumor	NOUN
bjp-13842	214	10	suppressor	suppressor	NOUN
bjp-13842	214	11	genes	gene	NOUN
bjp-13842	214	12	.	.	PUNCT
bjp-13842	215	1	nat	nat	PROPN
bjp-13842	215	2	med	med	PROPN
bjp-13842	215	3	.	.	PUNCT
bjp-13842	215	4	2001	2001	NUM
bjp-13842	215	5	;	;	PUNCT
bjp-13842	215	6	7	7	NUM
bjp-13842	215	7	:	:	SYM
bjp-13842	215	8	437	437	NUM
bjp-13842	215	9	-	-	SYM
bjp-13842	215	10	43	43	NUM
bjp-13842	215	11	.	.	PUNCT
bjp-13842	216	1	kong	kong	PROPN
bjp-13842	216	2	x	x	PROPN
bjp-13842	216	3	,	,	PUNCT
bjp-13842	216	4	lin	lin	PROPN
bjp-13842	216	5	z	z	PROPN
bjp-13842	216	6	,	,	PUNCT
bjp-13842	216	7	liang	liang	PROPN
bjp-13842	216	8	d	d	PROPN
bjp-13842	216	9	,	,	PUNCT
bjp-13842	216	10	fath	fath	PROPN
bjp-13842	216	11	d	d	PROPN
bjp-13842	216	12	,	,	PUNCT
bjp-13842	216	13	sang	sing	VERB
bjp-13842	216	14	n	n	CCONJ
bjp-13842	216	15	,	,	PUNCT
bjp-13842	216	16	caro	caro	PROPN
bjp-13842	216	17	j.	j.	PROPN
bjp-13842	216	18	histone	histone	PROPN
bjp-13842	216	19	deacetylase	deacetylase	VERB
bjp-13842	216	20	inhibitors	inhibitor	NOUN
bjp-13842	216	21	induce	induce	VERB
bjp-13842	216	22	vhl	vhl	NOUN
bjp-13842	216	23	and	and	CCONJ
bjp-13842	216	24	ubiquitinindependent	ubiquitinindependent	ADJ
bjp-13842	216	25	proteasomal	proteasomal	ADJ
bjp-13842	216	26	degradation	degradation	NOUN
bjp-13842	216	27	of	of	ADP
bjp-13842	216	28	hypoxia	hypoxia	NOUN
bjp-13842	216	29	-	-	PUNCT
bjp-13842	216	30	inducible	inducible	ADJ
bjp-13842	216	31	factor	factor	NOUN
bjp-13842	216	32	1alpha	1alpha	NUM
bjp-13842	216	33	.	.	PROPN
bjp-13842	217	1	mol	mol	ADP
bjp-13842	217	2	cell	cell	NOUN
bjp-13842	217	3	biol	biol	NOUN
bjp-13842	217	4	.	.	PUNCT
bjp-13842	218	1	2006	2006	NUM
bjp-13842	218	2	;	;	PUNCT
bjp-13842	218	3	26	26	NUM
bjp-13842	218	4	:	:	SYM
bjp-13842	218	5	2019	2019	NUM
bjp-13842	218	6	-	-	SYM
bjp-13842	218	7	28	28	NUM
bjp-13842	218	8	.	.	PUNCT
bjp-13842	219	1	liang	liang	PROPN
bjp-13842	219	2	d	d	PROPN
bjp-13842	219	3	,	,	PUNCT
bjp-13842	219	4	kong	kong	PROPN
bjp-13842	219	5	x	x	AUX
bjp-13842	219	6	,	,	PUNCT
bjp-13842	219	7	sang	sing	VERB
bjp-13842	219	8	n.	n.	NOUN
bjp-13842	219	9	effects	effect	NOUN
bjp-13842	219	10	of	of	ADP
bjp-13842	219	11	histone	histone	NOUN
bjp-13842	219	12	deacetylase	deacetylase	VERB
bjp-13842	219	13	inhibitors	inhibitor	NOUN
bjp-13842	219	14	on	on	ADP
bjp-13842	219	15	hif-1	hif-1	NUM
bjp-13842	219	16	.	.	PUNCT
bjp-13842	220	1	cell	cell	NOUN
bjp-13842	220	2	cycle	cycle	NOUN
bjp-13842	220	3	.	.	PUNCT
bjp-13842	221	1	2006	2006	NUM
bjp-13842	221	2	;	;	PUNCT
bjp-13842	221	3	5	5	NUM
bjp-13842	221	4	:	:	SYM
bjp-13842	221	5	2430	2430	NUM
bjp-13842	221	6	-	-	SYM
bjp-13842	221	7	35	35	NUM
bjp-13842	221	8	.	.	PUNCT
bjp-13842	222	1	mack	mack	PROPN
bjp-13842	222	2	fa	fa	PROPN
bjp-13842	222	3	,	,	PUNCT
bjp-13842	222	4	rathmell	rathmell	NOUN
bjp-13842	222	5	wk	wk	INTJ
bjp-13842	222	6	,	,	PUNCT
bjp-13842	222	7	arsham	arsham	PROPN
bjp-13842	222	8	am	be	AUX
bjp-13842	222	9	,	,	PUNCT
bjp-13842	222	10	gnarra	gnarra	PROPN
bjp-13842	222	11	j	j	PROPN
bjp-13842	222	12	,	,	PUNCT
bjp-13842	222	13	keith	keith	PROPN
bjp-13842	222	14	b	b	PROPN
bjp-13842	222	15	,	,	PUNCT
bjp-13842	222	16	simon	simon	PROPN
bjp-13842	222	17	mc	mc	PROPN
bjp-13842	222	18	.	.	PROPN
bjp-13842	222	19	loss	loss	PROPN
bjp-13842	222	20	of	of	ADP
bjp-13842	222	21	pvhl	pvhl	NOUN
bjp-13842	222	22	is	be	AUX
bjp-13842	222	23	sufficient	sufficient	ADJ
bjp-13842	222	24	to	to	PART
bjp-13842	222	25	cause	cause	VERB
bjp-13842	222	26	hif	hif	PROPN
bjp-13842	222	27	dysregulation	dysregulation	NOUN
bjp-13842	222	28	in	in	ADP
bjp-13842	222	29	primary	primary	ADJ
bjp-13842	222	30	cells	cell	NOUN
bjp-13842	222	31	but	but	CCONJ
bjp-13842	222	32	does	do	AUX
bjp-13842	222	33	not	not	PART
bjp-13842	222	34	promote	promote	VERB
bjp-13842	222	35	tumor	tumor	NOUN
bjp-13842	222	36	growth	growth	NOUN
bjp-13842	222	37	.	.	PUNCT
bjp-13842	223	1	cancer	cancer	NOUN
bjp-13842	223	2	cell	cell	NOUN
bjp-13842	223	3	.	.	PUNCT
bjp-13842	224	1	2003	2003	NUM
bjp-13842	224	2	;	;	PUNCT
bjp-13842	224	3	3	3	NUM
bjp-13842	224	4	:	:	SYM
bjp-13842	224	5	75	75	NUM
bjp-13842	224	6	-	-	SYM
bjp-13842	224	7	88	88	NUM
bjp-13842	224	8	.	.	PUNCT
bjp-13842	225	1	melillo	melillo	PROPN
bjp-13842	225	2	g.	g.	PROPN
bjp-13842	225	3	hypoxia	hypoxia	NOUN
bjp-13842	225	4	-	-	PUNCT
bjp-13842	225	5	inducible	inducible	ADJ
bjp-13842	225	6	factor	factor	NOUN
bjp-13842	225	7	1	1	NUM
bjp-13842	225	8	inhibitors	inhibitor	NOUN
bjp-13842	225	9	.	.	PUNCT
bjp-13842	226	1	methods	method	NOUN
bjp-13842	226	2	enzymol	enzymol	PROPN
bjp-13842	226	3	.	.	PUNCT
bjp-13842	227	1	2007	2007	NUM
bjp-13842	227	2	;	;	PUNCT
bjp-13842	227	3	435	435	NUM
bjp-13842	227	4	:	:	PUNCT
bjp-13842	227	5	385	385	NUM
bjp-13842	227	6	-	-	SYM
bjp-13842	227	7	402	402	NUM
bjp-13842	227	8	.	.	PUNCT
bjp-13842	228	1	patel	patel	PROPN
bjp-13842	228	2	sa	sa	PROPN
bjp-13842	228	3	,	,	PUNCT
bjp-13842	228	4	simon	simon	PROPN
bjp-13842	228	5	mc	mc	PROPN
bjp-13842	228	6	.	.	PROPN
bjp-13842	228	7	biology	biology	NOUN
bjp-13842	228	8	of	of	ADP
bjp-13842	228	9	hypoxia	hypoxia	NOUN
bjp-13842	228	10	-	-	PUNCT
bjp-13842	228	11	inducible	inducible	ADJ
bjp-13842	228	12	factor2alpha	factor2alpha	NOUN
bjp-13842	228	13	in	in	ADP
bjp-13842	228	14	development	development	NOUN
bjp-13842	228	15	and	and	CCONJ
bjp-13842	228	16	disease	disease	NOUN
bjp-13842	228	17	.	.	PUNCT
bjp-13842	229	1	cell	cell	NOUN
bjp-13842	229	2	death	death	NOUN
bjp-13842	229	3	differ	differ	VERB
bjp-13842	229	4	.	.	PUNCT
bjp-13842	229	5	2008	2008	NUM
bjp-13842	229	6	;	;	PUNCT
bjp-13842	229	7	15	15	NUM
bjp-13842	229	8	:	:	SYM
bjp-13842	229	9	628	628	NUM
bjp-13842	229	10	-	-	SYM
bjp-13842	229	11	34	34	NUM
bjp-13842	229	12	.	.	PUNCT
bjp-13842	230	1	qian	qian	PROPN
bjp-13842	230	2	dz	dz	PROPN
bjp-13842	230	3	,	,	PUNCT
bjp-13842	230	4	kachhap	kachhap	NOUN
bjp-13842	230	5	sk	sk	PROPN
bjp-13842	230	6	,	,	PUNCT
bjp-13842	230	7	collis	collis	PROPN
bjp-13842	230	8	sj	sj	PROPN
bjp-13842	230	9	,	,	PUNCT
bjp-13842	230	10	verheul	verheul	VERB
bjp-13842	230	11	hm	hm	INTJ
bjp-13842	230	12	,	,	PUNCT
bjp-13842	230	13	carducci	carducci	PROPN
bjp-13842	230	14	ma	ma	PROPN
bjp-13842	230	15	,	,	PUNCT
bjp-13842	230	16	atadja	atadja	PROPN
bjp-13842	230	17	p	p	X
bjp-13842	230	18	,	,	PUNCT
bjp-13842	230	19	pili	pili	NOUN
bjp-13842	230	20	r.	r.	PROPN
bjp-13842	230	21	class	class	PROPN
bjp-13842	230	22	ii	ii	PROPN
bjp-13842	230	23	histone	histone	NOUN
bjp-13842	230	24	deacetylases	deacetylase	NOUN
bjp-13842	230	25	are	be	AUX
bjp-13842	230	26	associated	associate	VERB
bjp-13842	230	27	with	with	ADP
bjp-13842	230	28	vhl	vhl	NOUN
bjp-13842	230	29	-	-	PUNCT
bjp-13842	230	30	independent	independent	ADJ
bjp-13842	230	31	regulation	regulation	NOUN
bjp-13842	230	32	of	of	ADP
bjp-13842	230	33	hypoxia	hypoxia	NOUN
bjp-13842	230	34	-	-	PUNCT
bjp-13842	230	35	inducible	inducible	ADJ
bjp-13842	230	36	factor	factor	NOUN
bjp-13842	230	37	1	1	NUM
bjp-13842	230	38	alpha	alpha	NOUN
bjp-13842	230	39	.	.	PUNCT
bjp-13842	231	1	cancer	cancer	NOUN
bjp-13842	231	2	res	re	NOUN
bjp-13842	231	3	.	.	PUNCT
bjp-13842	232	1	2006	2006	NUM
bjp-13842	232	2	;	;	PUNCT
bjp-13842	232	3	66	66	NUM
bjp-13842	232	4	:	:	SYM
bjp-13842	232	5	8814	8814	NUM
bjp-13842	232	6	-	-	SYM
bjp-13842	232	7	21	21	NUM
bjp-13842	232	8	.	.	PUNCT
bjp-13842	233	1	qian	qian	PROPN
bjp-13842	233	2	dz	dz	PROPN
bjp-13842	233	3	,	,	PUNCT
bjp-13842	233	4	wang	wang	PROPN
bjp-13842	233	5	x	x	PROPN
bjp-13842	233	6	,	,	PUNCT
bjp-13842	233	7	kachhap	kachhap	PROPN
bjp-13842	233	8	sk	sk	PROPN
bjp-13842	233	9	,	,	PUNCT
bjp-13842	233	10	kato	kato	PROPN
bjp-13842	233	11	y	y	PROPN
bjp-13842	233	12	,	,	PUNCT
bjp-13842	233	13	wei	wei	PROPN
bjp-13842	233	14	y	y	PROPN
bjp-13842	233	15	,	,	PUNCT
bjp-13842	233	16	zhang	zhang	PROPN
bjp-13842	233	17	l	l	PROPN
bjp-13842	233	18	,	,	PUNCT
bjp-13842	233	19	atadja	atadja	PROPN
bjp-13842	233	20	p	p	X
bjp-13842	233	21	,	,	PUNCT
bjp-13842	233	22	pili	pili	PROPN
bjp-13842	233	23	r.	r.	PROPN
bjp-13842	233	24	the	the	DET
bjp-13842	233	25	histone	histone	PROPN
bjp-13842	233	26	deacetylase	deacetylase	PROPN
bjp-13842	233	27	inhibitor	inhibitor	NOUN
bjp-13842	233	28	nvplaq824	nvplaq824	PROPN
bjp-13842	233	29	inhibits	inhibit	VERB
bjp-13842	233	30	angiogenesis	angiogenesis	NOUN
bjp-13842	233	31	and	and	CCONJ
bjp-13842	233	32	has	have	VERB
bjp-13842	233	33	a	a	DET
bjp-13842	233	34	greater	great	ADJ
bjp-13842	233	35	antitumor	antitumor	PROPN
bjp-13842	233	36	effect	effect	NOUN
bjp-13842	233	37	in	in	ADP
bjp-13842	233	38	combination	combination	NOUN
bjp-13842	233	39	with	with	ADP
bjp-13842	233	40	the	the	DET
bjp-13842	233	41	vascular	vascular	ADJ
bjp-13842	233	42	endothelial	endothelial	ADJ
bjp-13842	233	43	growth	growth	NOUN
bjp-13842	233	44	factor	factor	NOUN
bjp-13842	233	45	receptor	receptor	NOUN
bjp-13842	233	46	tyrosine	tyrosine	PROPN
bjp-13842	233	47	kinase	kinase	PROPN
bjp-13842	233	48	inhibitor	inhibitor	PROPN
bjp-13842	233	49	ptk787	ptk787	PROPN
bjp-13842	233	50	/	/	SYM
bjp-13842	233	51	zk222584	zk222584	PROPN
bjp-13842	233	52	.	.	PUNCT
bjp-13842	234	1	cancer	cancer	NOUN
bjp-13842	234	2	res	re	NOUN
bjp-13842	234	3	.	.	PUNCT
bjp-13842	234	4	2004	2004	NUM
bjp-13842	234	5	;	;	PUNCT
bjp-13842	234	6	64	64	NUM
bjp-13842	234	7	:	:	SYM
bjp-13842	234	8	6626	6626	NUM
bjp-13842	234	9	-	-	SYM
bjp-13842	234	10	34	34	NUM
bjp-13842	234	11	.	.	PUNCT
bjp-13842	235	1	qing	qe	VERB
bjp-13842	235	2	g	g	PROPN
bjp-13842	235	3	,	,	PUNCT
bjp-13842	235	4	simon	simon	PROPN
bjp-13842	235	5	mc	mc	PROPN
bjp-13842	235	6	.	.	PROPN
bjp-13842	235	7	hypoxia	hypoxia	PROPN
bjp-13842	235	8	inducible	inducible	ADJ
bjp-13842	235	9	factor-2alpha	factor-2alpha	PROPN
bjp-13842	235	10	:	:	PUNCT
bjp-13842	235	11	a	a	DET
bjp-13842	235	12	critical	critical	ADJ
bjp-13842	235	13	mediator	mediator	NOUN
bjp-13842	235	14	of	of	ADP
bjp-13842	235	15	aggressive	aggressive	ADJ
bjp-13842	235	16	tumor	tumor	NOUN
bjp-13842	235	17	phenotypes	phenotype	NOUN
bjp-13842	235	18	.	.	PUNCT
bjp-13842	236	1	curr	curr	PROPN
bjp-13842	236	2	opin	opin	PROPN
bjp-13842	236	3	genet	genet	PROPN
bjp-13842	236	4	dev	dev	PROPN
bjp-13842	236	5	.	.	PROPN
bjp-13842	236	6	2009	2009	NUM
bjp-13842	236	7	;	;	PUNCT
bjp-13842	236	8	19	19	NUM
bjp-13842	236	9	:	:	SYM
bjp-13842	236	10	60	60	NUM
bjp-13842	236	11	-	-	SYM
bjp-13842	236	12	65	65	NUM
bjp-13842	236	13	.	.	PUNCT
bjp-13842	237	1	semenza	semenza	PROPN
bjp-13842	237	2	gl	gl	PROPN
bjp-13842	237	3	.	.	PROPN
bjp-13842	237	4	defining	define	VERB
bjp-13842	237	5	the	the	DET
bjp-13842	237	6	role	role	NOUN
bjp-13842	237	7	of	of	ADP
bjp-13842	237	8	hypoxia	hypoxia	NOUN
bjp-13842	237	9	-	-	PUNCT
bjp-13842	237	10	inducible	inducible	ADJ
bjp-13842	237	11	factor	factor	NOUN
bjp-13842	237	12	1	1	NUM
bjp-13842	237	13	in	in	ADP
bjp-13842	237	14	cancer	cancer	NOUN
bjp-13842	237	15	biology	biology	NOUN
bjp-13842	237	16	and	and	CCONJ
bjp-13842	237	17	therapeutics	therapeutic	NOUN
bjp-13842	237	18	.	.	PUNCT
bjp-13842	238	1	oncogene	oncogene	NOUN
bjp-13842	238	2	.	.	PUNCT
bjp-13842	239	1	2010	2010	NUM
bjp-13842	239	2	;	;	PUNCT
bjp-13842	239	3	29	29	NUM
bjp-13842	239	4	:	:	SYM
bjp-13842	239	5	62534	62534	NUM
bjp-13842	239	6	.	.	PUNCT
bjp-13842	240	1	semenza	semenza	PROPN
bjp-13842	240	2	gl	gl	PROPN
bjp-13842	240	3	.	.	PROPN
bjp-13842	240	4	expression	expression	NOUN
bjp-13842	240	5	of	of	ADP
bjp-13842	240	6	hypoxia	hypoxia	NOUN
bjp-13842	240	7	-	-	PUNCT
bjp-13842	240	8	inducible	inducible	ADJ
bjp-13842	240	9	factor	factor	NOUN
bjp-13842	240	10	1	1	NUM
bjp-13842	240	11	:	:	PUNCT
bjp-13842	240	12	mechanisms	mechanism	NOUN
bjp-13842	240	13	and	and	CCONJ
bjp-13842	240	14	consequences	consequence	NOUN
bjp-13842	240	15	.	.	PUNCT
bjp-13842	241	1	biochem	biochem	PROPN
bjp-13842	241	2	pharm	pharm	PROPN
bjp-13842	241	3	.	.	PUNCT
bjp-13842	242	1	2000	2000	NUM
bjp-13842	242	2	;	;	PUNCT
bjp-13842	242	3	59	59	NUM
bjp-13842	242	4	:	:	SYM
bjp-13842	242	5	47	47	NUM
bjp-13842	242	6	-	-	SYM
bjp-13842	242	7	53	53	NUM
bjp-13842	242	8	.	.	PUNCT
bjp-13842	242	9	semenza	semenza	PROPN
bjp-13842	242	10	gl	gl	PROPN
bjp-13842	242	11	.	.	PROPN
bjp-13842	242	12	hypoxia	hypoxia	NOUN
bjp-13842	242	13	-	-	PUNCT
bjp-13842	242	14	inducible	inducible	ADJ
bjp-13842	242	15	factor	factor	NOUN
bjp-13842	242	16	1	1	NUM
bjp-13842	242	17	and	and	CCONJ
bjp-13842	242	18	cancer	cancer	NOUN
bjp-13842	242	19	pathogenesis	pathogenesis	NOUN
bjp-13842	242	20	.	.	PUNCT
bjp-13842	243	1	iubmb	iubmb	NOUN
bjp-13842	243	2	life	life	NOUN
bjp-13842	243	3	.	.	PUNCT
bjp-13842	244	1	2008	2008	NUM
bjp-13842	244	2	;	;	PUNCT
bjp-13842	245	1	60	60	NUM
bjp-13842	245	2	:	:	PUNCT
bjp-13842	245	3	591	591	NUM
bjp-13842	245	4	-	-	SYM
bjp-13842	245	5	97	97	NUM
bjp-13842	245	6	.	.	PUNCT
bjp-13842	245	7	semenza	semenza	PROPN
bjp-13842	245	8	gl	gl	PROPN
bjp-13842	245	9	.	.	PROPN
bjp-13842	245	10	regulation	regulation	NOUN
bjp-13842	245	11	of	of	ADP
bjp-13842	245	12	oxygen	oxygen	NOUN
bjp-13842	245	13	homeostasis	homeostasis	NOUN
bjp-13842	245	14	by	by	ADP
bjp-13842	245	15	hypoxiainducible	hypoxiainducible	ADJ
bjp-13842	245	16	factor	factor	NOUN
bjp-13842	245	17	1	1	NUM
bjp-13842	245	18	.	.	PUNCT
bjp-13842	246	1	physiology	physiology	NOUN
bjp-13842	246	2	(	(	PUNCT
bjp-13842	246	3	bethesda	bethesda	NOUN
bjp-13842	246	4	)	)	PUNCT
bjp-13842	246	5	.	.	PUNCT
bjp-13842	247	1	2009	2009	NUM
bjp-13842	247	2	;	;	PUNCT
bjp-13842	247	3	24	24	NUM
bjp-13842	247	4	:	:	PUNCT
bjp-13842	247	5	97	97	NUM
bjp-13842	247	6	-	-	SYM
bjp-13842	247	7	106	106	NUM
bjp-13842	247	8	vaupel	vaupel	NOUN
bjp-13842	247	9	p.	p.	NOUN
bjp-13842	247	10	tumor	tumor	NOUN
bjp-13842	247	11	microenvironmental	microenvironmental	ADJ
bjp-13842	247	12	physiology	physiology	NOUN
bjp-13842	247	13	and	and	CCONJ
bjp-13842	247	14	its	its	PRON
bjp-13842	247	15	implications	implication	NOUN
bjp-13842	247	16	for	for	ADP
bjp-13842	247	17	radiation	radiation	NOUN
bjp-13842	247	18	oncology	oncology	NOUN
bjp-13842	247	19	.	.	PUNCT
bjp-13842	248	1	semin	semin	PROPN
bjp-13842	248	2	radiat	radiat	PROPN
bjp-13842	248	3	oncol	oncol	PROPN
bjp-13842	248	4	.	.	PUNCT
bjp-13842	249	1	2004	2004	NUM
bjp-13842	249	2	;	;	PUNCT
bjp-13842	249	3	14	14	NUM
bjp-13842	249	4	:	:	SYM
bjp-13842	249	5	198	198	NUM
bjp-13842	249	6	-	-	SYM
bjp-13842	249	7	206	206	NUM
bjp-13842	249	8	.	.	PUNCT
bjp-13842	250	1	148	148	NUM
bjp-13842	250	2	bangladesh	bangladesh	NOUN
bjp-13842	250	3	j	j	PROPN
bjp-13842	250	4	pharmacol	pharmacol	PROPN
bjp-13842	250	5	2013	2013	NUM
bjp-13842	250	6	;	;	PUNCT
bjp-13842	250	7	8	8	NUM
bjp-13842	250	8	:	:	SYM
bjp-13842	250	9	142	142	NUM
bjp-13842	250	10	-	-	SYM
bjp-13842	250	11	148	148	NUM
bjp-13842	250	12	dateprinted	dateprinte	VERB
bjp-13842	250	13	:	:	PUNCT
bjp-13842	250	14	this	this	DET
bjp-13842	250	15	article	article	NOUN
bjp-13842	250	16	was	be	AUX
bjp-13842	250	17	downloaded	download	VERB
bjp-13842	250	18	by	by	ADP
bjp-13842	250	19	you	you	PRON
bjp-13842	250	20	on	on	ADP
bjp-13842	250	21	:	:	PUNCT
bjp-13842	250	22	aug	aug	PROPN
bjp-13842	250	23	13	13	NUM
bjp-13842	250	24	,	,	PUNCT
bjp-13842	250	25	2018	2018	NUM