id	sid	tid	token	lemma	pos
bjp-14679	1	1	bangladesh	bangladesh	PROPN
bjp-14679	1	2	journal	journal	PROPN
bjp-14679	1	3	of	of	ADP
bjp-14679	1	4	pharmacology	pharmacology	NOUN
bjp-14679	1	5	research	research	NOUN
bjp-14679	1	6	article	article	NOUN
bjp-14679	1	7	computational	computational	ADJ
bjp-14679	1	8	analysis	analysis	NOUN
bjp-14679	1	9	of	of	ADP
bjp-14679	1	10	cdh1	cdh1	NOUN
bjp-14679	1	11	missense	missense	NOUN
bjp-14679	1	12	mutations	mutation	NOUN
bjp-14679	1	13	in	in	ADP
bjp-14679	1	14	the	the	DET
bjp-14679	1	15	cause	cause	NOUN
bjp-14679	1	16	of	of	ADP
bjp-14679	1	17	hereditary	hereditary	ADJ
bjp-14679	1	18	diffuse	diffuse	NOUN
bjp-14679	1	19	gastric	gastric	ADJ
bjp-14679	1	20	cancer	cancer	NOUN
bjp-14679	1	21	bjp	bjp	PROPN
bjp-14679	1	22	a	a	DET
bjp-14679	1	23	b	b	PROPN
bjp-14679	1	24	c	c	NOUN
bjp-14679	1	25	d	d	X
bjp-14679	1	26	e	e	PROPN
bjp-14679	1	27	introduction	introduction	NOUN
bjp-14679	1	28	e	e	NOUN
bjp-14679	1	29	-	-	NOUN
bjp-14679	1	30	cadherin	cadherin	NOUN
bjp-14679	1	31	(	(	PUNCT
bjp-14679	1	32	cdh1	cdh1	NOUN
bjp-14679	1	33	)	)	PUNCT
bjp-14679	1	34	is	be	AUX
bjp-14679	1	35	cell	cell	NOUN
bjp-14679	1	36	-	-	PUNCT
bjp-14679	1	37	cell	cell	NOUN
bjp-14679	1	38	adhesion	adhesion	NOUN
bjp-14679	1	39	molecule	molecule	NOUN
bjp-14679	1	40	localized	localize	VERB
bjp-14679	1	41	in	in	ADP
bjp-14679	1	42	adherens	adheren	NOUN
bjp-14679	1	43	junctions	junction	NOUN
bjp-14679	1	44	.	.	PUNCT
bjp-14679	2	1	the	the	DET
bjp-14679	2	2	function	function	NOUN
bjp-14679	2	3	involves	involve	VERB
bjp-14679	2	4	polarity	polarity	NOUN
bjp-14679	2	5	,	,	PUNCT
bjp-14679	2	6	cell	cell	NOUN
bjp-14679	2	7	differentiation	differentiation	NOUN
bjp-14679	2	8	,	,	PUNCT
bjp-14679	2	9	tissue	tissue	NOUN
bjp-14679	2	10	integrity	integrity	NOUN
bjp-14679	2	11	and	and	CCONJ
bjp-14679	2	12	regulating	regulate	VERB
bjp-14679	2	13	signal	signal	NOUN
bjp-14679	2	14	transduction	transduction	NOUN
bjp-14679	2	15	pathways	pathway	NOUN
bjp-14679	2	16	(	(	PUNCT
bjp-14679	2	17	qian	qian	PROPN
bjp-14679	2	18	et	et	PROPN
bjp-14679	2	19	al	al	PROPN
bjp-14679	2	20	.	.	PROPN
bjp-14679	2	21	,	,	PUNCT
bjp-14679	2	22	2004	2004	NUM
bjp-14679	2	23	)	)	PUNCT
bjp-14679	2	24	.	.	PUNCT
bjp-14679	3	1	the	the	DET
bjp-14679	3	2	extracellular	extracellular	ADJ
bjp-14679	3	3	portion	portion	NOUN
bjp-14679	3	4	of	of	ADP
bjp-14679	3	5	the	the	DET
bjp-14679	3	6	protein	protein	NOUN
bjp-14679	3	7	mediates	mediate	NOUN
bjp-14679	3	8	homophilic	homophilic	ADJ
bjp-14679	3	9	cellular	cellular	ADJ
bjp-14679	3	10	interactions	interaction	NOUN
bjp-14679	3	11	,	,	PUNCT
bjp-14679	3	12	and	and	CCONJ
bjp-14679	3	13	intracellular	intracellular	ADJ
bjp-14679	3	14	part	part	NOUN
bjp-14679	3	15	provides	provide	VERB
bjp-14679	3	16	a	a	DET
bjp-14679	3	17	link	link	NOUN
bjp-14679	3	18	to	to	ADP
bjp-14679	3	19	the	the	DET
bjp-14679	3	20	actin	actin	NOUN
bjp-14679	3	21	cytoskeleton	cytoskeleton	PROPN
bjp-14679	3	22	through	through	ADP
bjp-14679	3	23	catenins	catenin	NOUN
bjp-14679	3	24	,	,	PUNCT
bjp-14679	3	25	a	a	DET
bjp-14679	3	26	multifunctional	multifunctional	ADJ
bjp-14679	3	27	protein	protein	NOUN
bjp-14679	3	28	associated	associate	VERB
bjp-14679	3	29	with	with	ADP
bjp-14679	3	30	cdh1	cdh1	PROPN
bjp-14679	3	31	gene	gene	NOUN
bjp-14679	3	32	(	(	PUNCT
bjp-14679	3	33	keller	keller	PROPN
bjp-14679	3	34	et	et	PROPN
bjp-14679	3	35	al	al	PROPN
bjp-14679	3	36	.	.	PROPN
bjp-14679	3	37	,	,	PUNCT
bjp-14679	3	38	1999	1999	NUM
bjp-14679	3	39	)	)	PUNCT
bjp-14679	3	40	.	.	PUNCT
bjp-14679	4	1	loss	loss	NOUN
bjp-14679	4	2	of	of	ADP
bjp-14679	4	3	function	function	NOUN
bjp-14679	4	4	or	or	CCONJ
bjp-14679	4	5	expression	expression	NOUN
bjp-14679	4	6	of	of	ADP
bjp-14679	4	7	e	e	NOUN
bjp-14679	4	8	-	-	NOUN
bjp-14679	4	9	cadherin	cadherin	NOUN
bjp-14679	4	10	increases	increase	VERB
bjp-14679	4	11	the	the	DET
bjp-14679	4	12	invasion	invasion	NOUN
bjp-14679	4	13	and	and	CCONJ
bjp-14679	4	14	metastasis	metastasis	NOUN
bjp-14679	4	15	of	of	ADP
bjp-14679	4	16	tumors	tumor	NOUN
bjp-14679	4	17	.	.	PUNCT
bjp-14679	5	1	it	it	PRON
bjp-14679	5	2	is	be	AUX
bjp-14679	5	3	being	be	AUX
bjp-14679	5	4	called	call	VERB
bjp-14679	5	5	as	as	ADP
bjp-14679	5	6	“	"	PUNCT
bjp-14679	5	7	suppression	suppression	NOUN
bjp-14679	5	8	of	of	ADP
bjp-14679	5	9	invasion	invasion	NOUN
bjp-14679	5	10	”	"	PUNCT
bjp-14679	5	11	gene	gene	NOUN
bjp-14679	5	12	.	.	PUNCT
bjp-14679	6	1	it	it	PRON
bjp-14679	6	2	includes	include	VERB
bjp-14679	6	3	dysfunction	dysfunction	NOUN
bjp-14679	6	4	of	of	ADP
bjp-14679	6	5	cell	cell	NOUN
bjp-14679	6	6	-	-	PUNCT
bjp-14679	6	7	cell	cell	NOUN
bjp-14679	6	8	adhesion	adhesion	NOUN
bjp-14679	6	9	,	,	PUNCT
bjp-14679	6	10	loss	loss	NOUN
bjp-14679	6	11	of	of	ADP
bjp-14679	6	12	tissue	tissue	NOUN
bjp-14679	6	13	integrity	integrity	NOUN
bjp-14679	6	14	,	,	PUNCT
bjp-14679	6	15	morphological	morphological	ADJ
bjp-14679	6	16	changes	change	NOUN
bjp-14679	6	17	,	,	PUNCT
bjp-14679	6	18	loss	loss	NOUN
bjp-14679	6	19	of	of	ADP
bjp-14679	6	20	heterozygosity	heterozygosity	NOUN
bjp-14679	6	21	(	(	PUNCT
bjp-14679	6	22	loh	loh	PROPN
bjp-14679	6	23	)	)	PUNCT
bjp-14679	6	24	and	and	CCONJ
bjp-14679	6	25	increased	increase	VERB
bjp-14679	6	26	proliferation	proliferation	NOUN
bjp-14679	6	27	.	.	PUNCT
bjp-14679	7	1	the	the	DET
bjp-14679	7	2	presence	presence	NOUN
bjp-14679	7	3	of	of	ADP
bjp-14679	7	4	cdh1	cdh1	NOUN
bjp-14679	7	5	in	in	ADP
bjp-14679	7	6	chromosome	chromosome	NOUN
bjp-14679	7	7	16q22.1	16q22.1	NUM
bjp-14679	7	8	was	be	AUX
bjp-14679	7	9	confirmed	confirm	VERB
bjp-14679	7	10	by	by	ADP
bjp-14679	7	11	the	the	DET
bjp-14679	7	12	researchers	researcher	NOUN
bjp-14679	7	13	(	(	PUNCT
bjp-14679	7	14	pećina	pećina	PROPN
bjp-14679	7	15	,	,	PUNCT
bjp-14679	7	16	2003	2003	NUM
bjp-14679	7	17	)	)	PUNCT
bjp-14679	7	18	.	.	PUNCT
bjp-14679	8	1	the	the	DET
bjp-14679	8	2	literature	literature	NOUN
bjp-14679	8	3	evidences	evidence	VERB
bjp-14679	8	4	available	available	ADJ
bjp-14679	8	5	suggest	suggest	VERB
bjp-14679	8	6	that	that	SCONJ
bjp-14679	8	7	missense	missense	NOUN
bjp-14679	8	8	mutation	mutation	NOUN
bjp-14679	8	9	in	in	ADP
bjp-14679	8	10	the	the	DET
bjp-14679	8	11	cdh1	cdh1	NOUN
bjp-14679	8	12	gene	gene	NOUN
bjp-14679	8	13	might	might	AUX
bjp-14679	8	14	causes	cause	VERB
bjp-14679	8	15	gastric	gastric	ADJ
bjp-14679	8	16	,	,	PUNCT
bjp-14679	8	17	breast	breast	NOUN
bjp-14679	8	18	,	,	PUNCT
bjp-14679	8	19	colorectal	colorectal	NOUN
bjp-14679	8	20	,	,	PUNCT
bjp-14679	8	21	thyroid	thyroid	NOUN
bjp-14679	8	22	,	,	PUNCT
bjp-14679	8	23	endometrium	endometrium	NOUN
bjp-14679	8	24	and	and	CCONJ
bjp-14679	8	25	ovarian	ovarian	ADJ
bjp-14679	8	26	cancers	cancer	NOUN
bjp-14679	8	27	(	(	PUNCT
bjp-14679	8	28	berx	berx	NOUN
bjp-14679	8	29	et	et	NOUN
bjp-14679	8	30	al	al	PROPN
bjp-14679	8	31	.	.	PROPN
bjp-14679	8	32	,	,	PUNCT
bjp-14679	8	33	1998	1998	NUM
bjp-14679	8	34	)	)	PUNCT
bjp-14679	8	35	.	.	PUNCT
bjp-14679	9	1	moreover	moreover	ADV
bjp-14679	9	2	,	,	PUNCT
bjp-14679	9	3	gastric	gastric	ADJ
bjp-14679	9	4	cancer	cancer	NOUN
bjp-14679	9	5	is	be	AUX
bjp-14679	9	6	more	more	ADV
bjp-14679	9	7	predominant	predominant	ADJ
bjp-14679	9	8	than	than	ADP
bjp-14679	9	9	the	the	DET
bjp-14679	9	10	other	other	ADJ
bjp-14679	9	11	cancer	cancer	NOUN
bjp-14679	9	12	types	type	NOUN
bjp-14679	9	13	especially	especially	ADV
bjp-14679	9	14	caused	cause	VERB
bjp-14679	9	15	by	by	ADP
bjp-14679	9	16	the	the	DET
bjp-14679	9	17	missense	missense	NOUN
bjp-14679	9	18	mutation	mutation	NOUN
bjp-14679	9	19	in	in	ADP
bjp-14679	9	20	cdh1	cdh1	PROPN
bjp-14679	9	21	gene	gene	NOUN
bjp-14679	9	22	(	(	PUNCT
bjp-14679	9	23	corso	corso	PROPN
bjp-14679	9	24	et	et	PROPN
bjp-14679	9	25	al	al	PROPN
bjp-14679	9	26	.	.	PROPN
bjp-14679	9	27	,	,	PUNCT
bjp-14679	9	28	2012	2012	NUM
bjp-14679	9	29	)	)	PUNCT
bjp-14679	9	30	.	.	PUNCT
bjp-14679	10	1	it	it	PRON
bjp-14679	10	2	is	be	AUX
bjp-14679	10	3	the	the	DET
bjp-14679	10	4	4th	4th	ADJ
bjp-14679	10	5	most	most	ADV
bjp-14679	10	6	common	common	ADJ
bjp-14679	10	7	cancer	cancer	NOUN
bjp-14679	10	8	and	and	CCONJ
bjp-14679	10	9	2nd	2nd	ADJ
bjp-14679	10	10	most	most	ADJ
bjp-14679	10	11	cancer	cancer	NOUN
bjp-14679	10	12	death	death	NOUN
bjp-14679	10	13	worldwide	worldwide	ADV
bjp-14679	10	14	(	(	PUNCT
bjp-14679	10	15	zhang	zhang	PROPN
bjp-14679	10	16	et	et	PROPN
bjp-14679	10	17	al	al	PROPN
bjp-14679	10	18	.	.	PROPN
bjp-14679	10	19	,	,	PUNCT
bjp-14679	10	20	2006	2006	NUM
bjp-14679	10	21	)	)	PUNCT
bjp-14679	10	22	.	.	PUNCT
bjp-14679	11	1	the	the	DET
bjp-14679	11	2	germline	germline	NOUN
bjp-14679	11	3	missense	missense	NOUN
bjp-14679	11	4	mutations	mutation	NOUN
bjp-14679	11	5	of	of	ADP
bjp-14679	11	6	e	e	NOUN
bjp-14679	11	7	-	-	NOUN
bjp-14679	11	8	cadherin	cadherin	NOUN
bjp-14679	11	9	resulting	result	VERB
bjp-14679	11	10	in	in	ADP
bjp-14679	11	11	e	e	NOUN
bjp-14679	11	12	-	-	NOUN
bjp-14679	11	13	cadherin	cadherin	NOUN
bjp-14679	11	14	inactivation	inactivation	NOUN
bjp-14679	11	15	was	be	AUX
bjp-14679	11	16	identified	identify	VERB
bjp-14679	11	17	as	as	ADP
bjp-14679	11	18	the	the	DET
bjp-14679	11	19	supreme	supreme	ADJ
bjp-14679	11	20	importance	importance	NOUN
bjp-14679	11	21	for	for	ADP
bjp-14679	11	22	the	the	DET
bjp-14679	11	23	hereditary	hereditary	ADJ
bjp-14679	11	24	diffuse	diffuse	NOUN
bjp-14679	11	25	gastric	gastric	ADJ
bjp-14679	11	26	cancer	cancer	NOUN
bjp-14679	11	27	(	(	PUNCT
bjp-14679	11	28	hdgc	hdgc	PROPN
bjp-14679	11	29	)	)	PUNCT
bjp-14679	11	30	(	(	PUNCT
bjp-14679	11	31	kim	kim	PROPN
bjp-14679	11	32	et	et	PROPN
bjp-14679	11	33	al	al	PROPN
bjp-14679	11	34	.	.	PROPN
bjp-14679	11	35	,	,	PUNCT
bjp-14679	11	36	2000	2000	NUM
bjp-14679	11	37	)	)	PUNCT
bjp-14679	11	38	.	.	PUNCT
bjp-14679	12	1	the	the	DET
bjp-14679	12	2	majority	majority	NOUN
bjp-14679	12	3	of	of	ADP
bjp-14679	12	4	the	the	DET
bjp-14679	12	5	families	family	NOUN
bjp-14679	12	6	with	with	ADP
bjp-14679	12	7	autosomal	autosomal	ADJ
bjp-14679	12	8	dominant	dominant	ADJ
bjp-14679	12	9	gastric	gastric	ADJ
bjp-14679	12	10	cancer	cancer	NOUN
bjp-14679	12	11	susceptibility	susceptibility	NOUN
bjp-14679	12	12	have	have	AUX
bjp-14679	12	13	hdgc	hdgc	VERB
bjp-14679	12	14	(	(	PUNCT
bjp-14679	12	15	oliveira	oliveira	PROPN
bjp-14679	12	16	et	et	PROPN
bjp-14679	12	17	al	al	PROPN
bjp-14679	12	18	.	.	PROPN
bjp-14679	12	19	,	,	PUNCT
bjp-14679	12	20	2004	2004	NUM
bjp-14679	12	21	;	;	PUNCT
bjp-14679	12	22	brooks	brooks	PROPN
bjp-14679	12	23	et	et	PROPN
bjp-14679	12	24	al	al	PROPN
bjp-14679	12	25	.	.	PROPN
bjp-14679	12	26	,	,	PUNCT
bjp-14679	12	27	2004	2004	NUM
bjp-14679	12	28	;	;	PUNCT
bjp-14679	12	29	kaurah	kaurah	PROPN
bjp-14679	12	30	et	et	PROPN
bjp-14679	12	31	al	al	PROPN
bjp-14679	12	32	.	.	PROPN
bjp-14679	12	33	,	,	PUNCT
bjp-14679	12	34	2007	2007	NUM
bjp-14679	12	35	)	)	PUNCT
bjp-14679	12	36	.	.	PUNCT
bjp-14679	13	1	e	e	X
bjp-14679	13	2	-	-	NOUN
bjp-14679	13	3	cadherin	cadherin	NOUN
bjp-14679	13	4	deficiency	deficiency	NOUN
bjp-14679	13	5	provides	provide	VERB
bjp-14679	13	6	an	an	DET
bjp-14679	13	7	obvious	obvious	ADJ
bjp-14679	13	8	explanation	explanation	NOUN
bjp-14679	13	9	for	for	ADP
bjp-14679	13	10	the	the	DET
bjp-14679	13	11	diffuse	diffuse	NOUN
bjp-14679	13	12	,	,	PUNCT
bjp-14679	13	13	scattered	scattered	ADJ
bjp-14679	13	14	growth	growth	NOUN
bjp-14679	13	15	of	of	ADP
bjp-14679	13	16	hdgc	hdgc	NOUN
bjp-14679	13	17	tumours	tumours	PROPN
bjp-14679	13	18	,	,	PUNCT
bjp-14679	13	19	as	as	SCONJ
bjp-14679	13	20	the	the	DET
bjp-14679	13	21	protein	protein	NOUN
bjp-14679	13	22	is	be	AUX
bjp-14679	13	23	the	the	DET
bjp-14679	13	24	central	central	ADJ
bjp-14679	13	25	component	component	NOUN
bjp-14679	13	26	of	of	ADP
bjp-14679	13	27	epithelial	epithelial	ADJ
bjp-14679	13	28	cell	cell	NOUN
bjp-14679	13	29	-	-	PUNCT
bjp-14679	13	30	to	to	ADP
bjp-14679	13	31	-	-	PUNCT
bjp-14679	13	32	cell	cell	NOUN
bjp-14679	13	33	adhesion	adhesion	NOUN
bjp-14679	13	34	junctions	junction	NOUN
bjp-14679	13	35	and	and	CCONJ
bjp-14679	13	36	as	as	ADP
bjp-14679	13	37	such	such	ADJ
bjp-14679	13	38	is	be	AUX
bjp-14679	13	39	required	require	VERB
bjp-14679	13	40	for	for	ADP
bjp-14679	13	41	the	the	DET
bjp-14679	13	42	integrity	integrity	NOUN
bjp-14679	13	43	of	of	ADP
bjp-14679	13	44	epithelial	epithelial	ADJ
bjp-14679	13	45	layers	layer	NOUN
bjp-14679	13	46	(	(	PUNCT
bjp-14679	13	47	more	more	ADJ
bjp-14679	13	48	et	et	NOUN
bjp-14679	13	49	al	al	PROPN
bjp-14679	13	50	.	.	PROPN
bjp-14679	13	51	,	,	PUNCT
bjp-14679	13	52	2007	2007	NUM
bjp-14679	13	53	)	)	PUNCT
bjp-14679	13	54	.	.	PUNCT
bjp-14679	14	1	in	in	ADP
bjp-14679	14	2	gastric	gastric	ADJ
bjp-14679	14	3	cancer	cancer	NOUN
bjp-14679	14	4	a	a	DET
bjp-14679	14	5	series	series	NOUN
bjp-14679	14	6	of	of	ADP
bjp-14679	14	7	trials	trial	NOUN
bjp-14679	14	8	have	have	AUX
bjp-14679	14	9	produced	produce	VERB
bjp-14679	14	10	evidence	evidence	NOUN
bjp-14679	14	11	that	that	SCONJ
bjp-14679	14	12	chemotherapy	chemotherapy	NOUN
bjp-14679	14	13	increases	increase	VERB
bjp-14679	14	14	survival	survival	NOUN
bjp-14679	14	15	.	.	PUNCT
bjp-14679	15	1	there	there	PRON
bjp-14679	15	2	are	be	VERB
bjp-14679	15	3	so	so	ADV
bjp-14679	15	4	many	many	ADJ
bjp-14679	15	5	drugs	drug	NOUN
bjp-14679	15	6	available	available	ADJ
bjp-14679	15	7	for	for	ADP
bjp-14679	15	8	the	the	DET
bjp-14679	15	9	chemotherapy	chemotherapy	NOUN
bjp-14679	15	10	treatment	treatment	NOUN
bjp-14679	15	11	a	a	DET
bjp-14679	15	12	journal	journal	NOUN
bjp-14679	15	13	of	of	ADP
bjp-14679	15	14	the	the	DET
bjp-14679	15	15	bangladesh	bangladesh	NOUN
bjp-14679	15	16	pharmacological	pharmacological	ADJ
bjp-14679	15	17	society	society	NOUN
bjp-14679	15	18	(	(	PUNCT
bjp-14679	15	19	bdps	bdps	NOUN
bjp-14679	15	20	)	)	PUNCT
bjp-14679	15	21	bangladesh	bangladesh	PROPN
bjp-14679	15	22	j	j	PROPN
bjp-14679	15	23	pharmacol	pharmacol	PROPN
bjp-14679	15	24	2013	2013	NUM
bjp-14679	15	25	;	;	PUNCT
bjp-14679	15	26	8	8	NUM
bjp-14679	15	27	:	:	SYM
bjp-14679	15	28	207	207	NUM
bjp-14679	15	29	-	-	SYM
bjp-14679	15	30	213	213	NUM
bjp-14679	15	31	journal	journal	NOUN
bjp-14679	15	32	homepage	homepage	NOUN
bjp-14679	15	33	:	:	PUNCT
bjp-14679	15	34	www.banglajol.info	www.banglajol.info	PROPN
bjp-14679	15	35	abstracted	abstract	VERB
bjp-14679	15	36	/	/	SYM
bjp-14679	15	37	indexed	index	VERB
bjp-14679	15	38	in	in	ADP
bjp-14679	15	39	academic	academic	ADJ
bjp-14679	15	40	search	search	NOUN
bjp-14679	15	41	complete	complete	ADJ
bjp-14679	15	42	,	,	PUNCT
bjp-14679	15	43	agroforestry	agroforestry	NOUN
bjp-14679	15	44	abstracts	abstract	NOUN
bjp-14679	15	45	,	,	PUNCT
bjp-14679	15	46	asia	asia	PROPN
bjp-14679	15	47	journals	journal	NOUN
bjp-14679	15	48	online	online	ADV
bjp-14679	15	49	,	,	PUNCT
bjp-14679	15	50	bangladesh	bangladesh	NOUN
bjp-14679	15	51	journals	journal	NOUN
bjp-14679	15	52	online	online	ADV
bjp-14679	15	53	,	,	PUNCT
bjp-14679	15	54	biological	biological	ADJ
bjp-14679	15	55	abstracts	abstract	NOUN
bjp-14679	15	56	,	,	PUNCT
bjp-14679	15	57	biosis	biosis	NOUN
bjp-14679	15	58	previews	preview	NOUN
bjp-14679	15	59	,	,	PUNCT
bjp-14679	15	60	cab	cab	NOUN
bjp-14679	15	61	abstracts	abstract	NOUN
bjp-14679	15	62	,	,	PUNCT
bjp-14679	15	63	current	current	ADJ
bjp-14679	15	64	abstracts	abstract	NOUN
bjp-14679	15	65	,	,	PUNCT
bjp-14679	15	66	directory	directory	NOUN
bjp-14679	15	67	of	of	ADP
bjp-14679	15	68	open	open	ADJ
bjp-14679	15	69	access	access	NOUN
bjp-14679	15	70	journals	journal	NOUN
bjp-14679	15	71	,	,	PUNCT
bjp-14679	15	72	embase	embase	NOUN
bjp-14679	15	73	/	/	SYM
bjp-14679	15	74	excerpta	excerpta	NOUN
bjp-14679	15	75	medica	medica	NOUN
bjp-14679	15	76	,	,	PUNCT
bjp-14679	15	77	google	google	PROPN
bjp-14679	15	78	scholar	scholar	NOUN
bjp-14679	15	79	,	,	PUNCT
bjp-14679	15	80	hinari	hinari	X
bjp-14679	15	81	(	(	PUNCT
bjp-14679	15	82	who	who	PRON
bjp-14679	15	83	)	)	PUNCT
bjp-14679	15	84	,	,	PUNCT
bjp-14679	15	85	international	international	ADJ
bjp-14679	15	86	pharmaceutical	pharmaceutical	ADJ
bjp-14679	15	87	abstracts	abstract	NOUN
bjp-14679	15	88	,	,	PUNCT
bjp-14679	15	89	open	open	ADJ
bjp-14679	15	90	j	j	PROPN
bjp-14679	15	91	-	-	PUNCT
bjp-14679	15	92	gate	gate	NOUN
bjp-14679	15	93	,	,	PUNCT
bjp-14679	15	94	science	science	NOUN
bjp-14679	15	95	citation	citation	NOUN
bjp-14679	15	96	index	index	NOUN
bjp-14679	15	97	expanded	expand	VERB
bjp-14679	15	98	,	,	PUNCT
bjp-14679	15	99	scopus	scopus	NOUN
bjp-14679	15	100	and	and	CCONJ
bjp-14679	15	101	social	social	ADJ
bjp-14679	15	102	sciences	sciences	PROPN
bjp-14679	15	103	citation	citation	NOUN
bjp-14679	15	104	index	index	NOUN
bjp-14679	15	105	issn	issn	PROPN
bjp-14679	15	106	:	:	PUNCT
bjp-14679	15	107	1991	1991	NUM
bjp-14679	15	108	-	-	SYM
bjp-14679	15	109	0088	0088	NUM
bjp-14679	15	110	computational	computational	ADJ
bjp-14679	15	111	analysis	analysis	NOUN
bjp-14679	15	112	of	of	ADP
bjp-14679	15	113	cdh1	cdh1	NOUN
bjp-14679	15	114	missense	missense	NOUN
bjp-14679	15	115	mutations	mutation	NOUN
bjp-14679	15	116	in	in	ADP
bjp-14679	15	117	the	the	DET
bjp-14679	15	118	cause	cause	NOUN
bjp-14679	15	119	of	of	ADP
bjp-14679	15	120	hereditary	hereditary	ADJ
bjp-14679	15	121	diffuse	diffuse	NOUN
bjp-14679	15	122	gastric	gastric	ADJ
bjp-14679	15	123	cancer	cancer	NOUN
bjp-14679	15	124	s.	s.	PROPN
bjp-14679	15	125	santhiya1	santhiya1	PROPN
bjp-14679	15	126	,	,	PUNCT
bjp-14679	15	127	v.	v.	ADP
bjp-14679	15	128	shanthi2	shanthi2	NOUN
bjp-14679	15	129	,	,	PUNCT
bjp-14679	15	130	r.	r.	PROPN
bjp-14679	15	131	rajasekaran1	rajasekaran1	PROPN
bjp-14679	15	132	and	and	CCONJ
bjp-14679	15	133	karuppasamy	karuppasamy	VERB
bjp-14679	15	134	ramanathan1	ramanathan1	PROPN
bjp-14679	15	135	1bioinformatics	1bioinformatics	NUM
bjp-14679	15	136	division	division	NOUN
bjp-14679	15	137	,	,	PUNCT
bjp-14679	15	138	2industrial	2industrial	NUM
bjp-14679	15	139	biotechnology	biotechnology	NOUN
bjp-14679	15	140	division	division	NOUN
bjp-14679	15	141	,	,	PUNCT
bjp-14679	15	142	school	school	NOUN
bjp-14679	15	143	of	of	ADP
bjp-14679	15	144	bio	bio	PROPN
bjp-14679	15	145	sciences	sciences	PROPN
bjp-14679	15	146	and	and	CCONJ
bjp-14679	15	147	technology	technology	NOUN
bjp-14679	15	148	,	,	PUNCT
bjp-14679	15	149	vellore	vellore	PROPN
bjp-14679	15	150	institute	institute	PROPN
bjp-14679	15	151	of	of	ADP
bjp-14679	15	152	technology	technology	PROPN
bjp-14679	15	153	,	,	PUNCT
bjp-14679	15	154	vellore	vellore	NOUN
bjp-14679	15	155	632014	632014	NUM
bjp-14679	15	156	,	,	PUNCT
bjp-14679	15	157	tamil	tamil	PROPN
bjp-14679	15	158	nadu	nadu	PROPN
bjp-14679	15	159	,	,	PUNCT
bjp-14679	15	160	india	india	PROPN
bjp-14679	15	161	.	.	PUNCT
bjp-14679	16	1	abstract	abstract	ADJ
bjp-14679	16	2	in	in	ADP
bjp-14679	16	3	this	this	DET
bjp-14679	16	4	present	present	ADJ
bjp-14679	16	5	study	study	NOUN
bjp-14679	16	6	,	,	PUNCT
bjp-14679	16	7	we	we	PRON
bjp-14679	16	8	computationally	computationally	ADV
bjp-14679	16	9	identified	identify	VERB
bjp-14679	16	10	the	the	DET
bjp-14679	16	11	germline	germline	NOUN
bjp-14679	16	12	missense	missense	NOUN
bjp-14679	16	13	mutation	mutation	NOUN
bjp-14679	16	14	in	in	ADP
bjp-14679	16	15	the	the	DET
bjp-14679	16	16	e	e	NOUN
bjp-14679	16	17	-	-	NOUN
bjp-14679	16	18	cadherin	cadherin	NOUN
bjp-14679	16	19	(	(	PUNCT
bjp-14679	16	20	cdh1	cdh1	NOUN
bjp-14679	16	21	)	)	PUNCT
bjp-14679	16	22	gene	gene	NOUN
bjp-14679	16	23	causing	cause	VERB
bjp-14679	16	24	hereditary	hereditary	ADJ
bjp-14679	16	25	diffuse	diffuse	NOUN
bjp-14679	16	26	gastric	gastric	ADJ
bjp-14679	16	27	cancer	cancer	NOUN
bjp-14679	16	28	(	(	PUNCT
bjp-14679	16	29	hdgc	hdgc	NOUN
bjp-14679	16	30	)	)	PUNCT
bjp-14679	16	31	.	.	PUNCT
bjp-14679	17	1	the	the	DET
bjp-14679	17	2	analysis	analysis	NOUN
bjp-14679	17	3	was	be	AUX
bjp-14679	17	4	initiated	initiate	VERB
bjp-14679	17	5	with	with	ADP
bjp-14679	17	6	sift	sift	NOUN
bjp-14679	17	7	followed	follow	VERB
bjp-14679	17	8	by	by	ADP
bjp-14679	17	9	polyphen	polyphen	ADV
bjp-14679	18	1	and	and	CCONJ
bjp-14679	18	2	i	i	PRON
bjp-14679	18	3	-	-	PUNCT
bjp-14679	18	4	mutant2.0	mutant2.0	PROPN
bjp-14679	18	5	programs	program	NOUN
bjp-14679	18	6	with	with	ADP
bjp-14679	18	7	the	the	DET
bjp-14679	18	8	help	help	NOUN
bjp-14679	18	9	of	of	ADP
bjp-14679	18	10	68	68	NUM
bjp-14679	18	11	cdh1	cdh1	NOUN
bjp-14679	18	12	variants	variant	NOUN
bjp-14679	18	13	retrieved	retrieve	VERB
bjp-14679	18	14	from	from	ADP
bjp-14679	18	15	dbsnp	dbsnp	PROPN
bjp-14679	18	16	.	.	PUNCT
bjp-14679	19	1	the	the	DET
bjp-14679	19	2	analysis	analysis	NOUN
bjp-14679	19	3	indicates	indicate	VERB
bjp-14679	19	4	that	that	SCONJ
bjp-14679	19	5	10	10	NUM
bjp-14679	19	6	variants	variant	NOUN
bjp-14679	19	7	such	such	ADJ
bjp-14679	19	8	as	as	ADP
bjp-14679	19	9	p201r	p201r	PROPN
bjp-14679	19	10	,	,	PUNCT
bjp-14679	19	11	a298	a298	PROPN
bjp-14679	19	12	t	t	PROPN
bjp-14679	19	13	,	,	PUNCT
bjp-14679	19	14	e336d	e336d	PROPN
bjp-14679	19	15	,	,	PUNCT
bjp-14679	19	16	c695r	c695r	PROPN
bjp-14679	19	17	,	,	PUNCT
bjp-14679	19	18	n751k	n751k	PROPN
bjp-14679	19	19	,	,	PUNCT
bjp-14679	19	20	y755c	y755c	PROPN
bjp-14679	19	21	,	,	PUNCT
bjp-14679	19	22	d768n	d768n	PROPN
bjp-14679	19	23	,	,	PUNCT
bjp-14679	19	24	g879s	g879s	PROPN
bjp-14679	19	25	,	,	PUNCT
bjp-14679	19	26	d882n	d882n	PROPN
bjp-14679	19	27	and	and	CCONJ
bjp-14679	19	28	r169h	r169h	NOUN
bjp-14679	19	29	were	be	AUX
bjp-14679	19	30	commonly	commonly	ADV
bjp-14679	19	31	found	find	VERB
bjp-14679	19	32	to	to	PART
bjp-14679	19	33	be	be	AUX
bjp-14679	19	34	less	less	ADV
bjp-14679	19	35	stable	stable	ADJ
bjp-14679	19	36	and	and	CCONJ
bjp-14679	19	37	damaging	damaging	ADJ
bjp-14679	19	38	by	by	ADP
bjp-14679	19	39	sift	sift	ADJ
bjp-14679	19	40	,	,	PUNCT
bjp-14679	19	41	polyphen	polyphen	ADV
bjp-14679	19	42	and	and	CCONJ
bjp-14679	19	43	i	i	PROPN
bjp-14679	19	44	-	-	PUNCT
bjp-14679	19	45	mutant2.0	mutant2.0	PROPN
bjp-14679	19	46	programs	program	NOUN
bjp-14679	19	47	.	.	PUNCT
bjp-14679	20	1	furthermore	furthermore	ADV
bjp-14679	20	2	,	,	PUNCT
bjp-14679	20	3	snps	snps	PROPN
bjp-14679	20	4	and	and	CCONJ
bjp-14679	20	5	go	go	VERB
bjp-14679	20	6	was	be	AUX
bjp-14679	20	7	used	use	VERB
bjp-14679	20	8	to	to	PART
bjp-14679	20	9	predict	predict	VERB
bjp-14679	20	10	the	the	DET
bjp-14679	20	11	disease	disease	NOUN
bjp-14679	20	12	related	relate	VERB
bjp-14679	20	13	mutations	mutation	NOUN
bjp-14679	20	14	from	from	ADP
bjp-14679	20	15	the	the	DET
bjp-14679	20	16	protein	protein	NOUN
bjp-14679	20	17	sequence	sequence	NOUN
bjp-14679	20	18	.	.	PUNCT
bjp-14679	21	1	finally	finally	ADV
bjp-14679	21	2	,	,	PUNCT
bjp-14679	21	3	the	the	DET
bjp-14679	21	4	affinities	affinity	NOUN
bjp-14679	21	5	for	for	ADP
bjp-14679	21	6	the	the	DET
bjp-14679	21	7	cetuximab	cetuximab	NOUN
bjp-14679	21	8	with	with	ADP
bjp-14679	21	9	cdh1	cdh1	PROPN
bjp-14679	21	10	variants	variant	NOUN
bjp-14679	21	11	were	be	AUX
bjp-14679	21	12	examined	examine	VERB
bjp-14679	21	13	by	by	ADP
bjp-14679	21	14	using	use	VERB
bjp-14679	21	15	molecular	molecular	ADJ
bjp-14679	21	16	docking	docking	NOUN
bjp-14679	21	17	algorithm	algorithm	NOUN
bjp-14679	21	18	.	.	PUNCT
bjp-14679	22	1	the	the	DET
bjp-14679	22	2	result	result	NOUN
bjp-14679	22	3	showed	show	VERB
bjp-14679	22	4	that	that	SCONJ
bjp-14679	22	5	p201r	p201r	PROPN
bjp-14679	22	6	,	,	PUNCT
bjp-14679	22	7	a298	a298	PROPN
bjp-14679	22	8	t	t	PROPN
bjp-14679	22	9	,	,	PUNCT
bjp-14679	22	10	e336d	e336d	PROPN
bjp-14679	22	11	and	and	CCONJ
bjp-14679	22	12	r169h	r169h	PROPN
bjp-14679	22	13	variants	variant	NOUN
bjp-14679	22	14	were	be	AUX
bjp-14679	22	15	found	find	VERB
bjp-14679	22	16	to	to	PART
bjp-14679	22	17	be	be	AUX
bjp-14679	22	18	highly	highly	ADV
bjp-14679	22	19	significant	significant	ADJ
bjp-14679	22	20	than	than	ADP
bjp-14679	22	21	the	the	DET
bjp-14679	22	22	other	other	ADJ
bjp-14679	22	23	mutations	mutation	NOUN
bjp-14679	22	24	considered	consider	VERB
bjp-14679	22	25	in	in	ADP
bjp-14679	22	26	our	our	PRON
bjp-14679	22	27	analysis	analysis	NOUN
bjp-14679	22	28	.	.	PUNCT
bjp-14679	23	1	we	we	PRON
bjp-14679	23	2	sincerely	sincerely	ADV
bjp-14679	23	3	hope	hope	VERB
bjp-14679	23	4	that	that	SCONJ
bjp-14679	23	5	these	these	DET
bjp-14679	23	6	findings	finding	NOUN
bjp-14679	23	7	certainly	certainly	ADV
bjp-14679	23	8	helpful	helpful	ADJ
bjp-14679	23	9	for	for	ADP
bjp-14679	23	10	the	the	DET
bjp-14679	23	11	experimental	experimental	ADJ
bjp-14679	23	12	biologist	biologist	NOUN
bjp-14679	23	13	working	work	VERB
bjp-14679	23	14	in	in	ADP
bjp-14679	23	15	hdgc	hdgc	NOUN
bjp-14679	23	16	drug	drug	NOUN
bjp-14679	23	17	development	development	NOUN
bjp-14679	23	18	.	.	PUNCT
bjp-14679	24	1	article	article	NOUN
bjp-14679	24	2	info	info	NOUN
bjp-14679	24	3	received	receive	VERB
bjp-14679	24	4	:	:	PUNCT
bjp-14679	24	5	20	20	NUM
bjp-14679	24	6	april	april	PROPN
bjp-14679	24	7	2013	2013	NUM
bjp-14679	24	8	accepted	accept	VERB
bjp-14679	24	9	:	:	PUNCT
bjp-14679	25	1	25	25	NUM
bjp-14679	25	2	april	april	PROPN
bjp-14679	25	3	2013	2013	NUM
bjp-14679	25	4	available	available	ADJ
bjp-14679	25	5	online	online	NOUN
bjp-14679	25	6	:	:	PUNCT
bjp-14679	25	7	7	7	NUM
bjp-14679	25	8	may	may	PROPN
bjp-14679	25	9	2013	2013	NUM
bjp-14679	25	10	doi	doi	NOUN
bjp-14679	25	11	:	:	PUNCT
bjp-14679	25	12	10.3329	10.3329	NUM
bjp-14679	25	13	/	/	SYM
bjp-14679	25	14	bjp.v8i2.14679	bjp.v8i2.14679	PROPN
bjp-14679	25	15	cite	cite	VERB
bjp-14679	25	16	this	this	DET
bjp-14679	25	17	article	article	NOUN
bjp-14679	25	18	:	:	PUNCT
bjp-14679	25	19	santhiya	santhiya	PROPN
bjp-14679	25	20	s	s	PROPN
bjp-14679	25	21	,	,	PUNCT
bjp-14679	25	22	shanthi	shanthi	PROPN
bjp-14679	25	23	v	v	PROPN
bjp-14679	25	24	,	,	PUNCT
bjp-14679	25	25	rajasekaran	rajasekaran	NOUN
bjp-14679	25	26	r	r	NOUN
bjp-14679	25	27	,	,	PUNCT
bjp-14679	25	28	ramanathan	ramanathan	PROPN
bjp-14679	25	29	k.	k.	PROPN
bjp-14679	25	30	computational	computational	ADJ
bjp-14679	25	31	analysis	analysis	NOUN
bjp-14679	25	32	of	of	ADP
bjp-14679	25	33	cdh1	cdh1	NOUN
bjp-14679	25	34	missense	missense	NOUN
bjp-14679	25	35	mutations	mutation	NOUN
bjp-14679	25	36	in	in	ADP
bjp-14679	25	37	the	the	DET
bjp-14679	25	38	cause	cause	NOUN
bjp-14679	25	39	of	of	ADP
bjp-14679	25	40	hereditary	hereditary	ADJ
bjp-14679	25	41	diffuse	diffuse	NOUN
bjp-14679	25	42	gastric	gastric	ADJ
bjp-14679	25	43	cancer	cancer	NOUN
bjp-14679	25	44	.	.	PUNCT
bjp-14679	26	1	bangladesh	bangladesh	PROPN
bjp-14679	26	2	j	j	PROPN
bjp-14679	26	3	pharmacol	pharmacol	PROPN
bjp-14679	26	4	.	.	PUNCT
bjp-14679	27	1	2013	2013	NUM
bjp-14679	27	2	;	;	PUNCT
bjp-14679	27	3	8	8	NUM
bjp-14679	27	4	:	:	SYM
bjp-14679	27	5	207	207	NUM
bjp-14679	27	6	-	-	SYM
bjp-14679	27	7	13	13	NUM
bjp-14679	27	8	.	.	PUNCT
bjp-14679	28	1	this	this	DET
bjp-14679	28	2	work	work	NOUN
bjp-14679	28	3	is	be	AUX
bjp-14679	28	4	licensed	license	VERB
bjp-14679	28	5	under	under	ADP
bjp-14679	28	6	a	a	DET
bjp-14679	28	7	creative	creative	ADJ
bjp-14679	28	8	commons	common	NOUN
bjp-14679	28	9	attribution	attribution	NOUN
bjp-14679	28	10	3.0	3.0	NUM
bjp-14679	28	11	license	license	NOUN
bjp-14679	28	12	.	.	PUNCT
bjp-14679	29	1	you	you	PRON
bjp-14679	29	2	are	be	AUX
bjp-14679	29	3	free	free	ADJ
bjp-14679	29	4	to	to	PART
bjp-14679	29	5	copy	copy	VERB
bjp-14679	29	6	,	,	PUNCT
bjp-14679	29	7	distribute	distribute	VERB
bjp-14679	29	8	and	and	CCONJ
bjp-14679	29	9	perform	perform	VERB
bjp-14679	29	10	the	the	DET
bjp-14679	29	11	work	work	NOUN
bjp-14679	29	12	.	.	PUNCT
bjp-14679	30	1	you	you	PRON
bjp-14679	30	2	must	must	AUX
bjp-14679	30	3	attribute	attribute	VERB
bjp-14679	30	4	the	the	DET
bjp-14679	30	5	work	work	NOUN
bjp-14679	30	6	in	in	ADP
bjp-14679	30	7	the	the	DET
bjp-14679	30	8	manner	manner	NOUN
bjp-14679	30	9	specified	specify	VERB
bjp-14679	30	10	by	by	ADP
bjp-14679	30	11	the	the	DET
bjp-14679	30	12	author	author	NOUN
bjp-14679	30	13	or	or	CCONJ
bjp-14679	30	14	licensor	licensor	NOUN
bjp-14679	30	15	.	.	PUNCT
bjp-14679	31	1	(	(	PUNCT
bjp-14679	31	2	nishiyama	nishiyama	NOUN
bjp-14679	31	3	and	and	CCONJ
bjp-14679	31	4	wada	wada	PROPN
bjp-14679	31	5	,	,	PUNCT
bjp-14679	31	6	2009	2009	NUM
bjp-14679	31	7	;	;	PUNCT
bjp-14679	31	8	graziano	graziano	PROPN
bjp-14679	31	9	et	et	PROPN
bjp-14679	31	10	al	al	PROPN
bjp-14679	31	11	.	.	PROPN
bjp-14679	31	12	,	,	PUNCT
bjp-14679	31	13	2004	2004	NUM
bjp-14679	31	14	;	;	PUNCT
bjp-14679	31	15	zhang	zhang	PROPN
bjp-14679	31	16	et	et	PROPN
bjp-14679	31	17	al	al	PROPN
bjp-14679	31	18	.	.	PROPN
bjp-14679	31	19	,	,	PUNCT
bjp-14679	31	20	2013	2013	NUM
bjp-14679	31	21	)	)	PUNCT
bjp-14679	31	22	.	.	PUNCT
bjp-14679	32	1	however	however	ADV
bjp-14679	32	2	,	,	PUNCT
bjp-14679	32	3	the	the	DET
bjp-14679	32	4	cetuximab	cetuximab	NOUN
bjp-14679	32	5	proved	prove	VERB
bjp-14679	32	6	to	to	PART
bjp-14679	32	7	be	be	AUX
bjp-14679	32	8	effective	effective	ADJ
bjp-14679	32	9	drug	drug	NOUN
bjp-14679	32	10	for	for	ADP
bjp-14679	32	11	the	the	DET
bjp-14679	32	12	treatment	treatment	NOUN
bjp-14679	32	13	of	of	ADP
bjp-14679	32	14	hdgc	hdgc	NOUN
bjp-14679	32	15	(	(	PUNCT
bjp-14679	32	16	cunningham	cunningham	PROPN
bjp-14679	32	17	et	et	PROPN
bjp-14679	32	18	al	al	PROPN
bjp-14679	32	19	.	.	PROPN
bjp-14679	32	20	,	,	PUNCT
bjp-14679	32	21	2004	2004	NUM
bjp-14679	32	22	)	)	PUNCT
bjp-14679	32	23	.	.	PUNCT
bjp-14679	33	1	e	e	X
bjp-14679	33	2	-	-	NOUN
bjp-14679	33	3	cadherin	cadherin	NOUN
bjp-14679	33	4	expression	expression	NOUN
bjp-14679	33	5	increases	increase	VERB
bjp-14679	33	6	the	the	DET
bjp-14679	33	7	sensitivity	sensitivity	NOUN
bjp-14679	33	8	to	to	PART
bjp-14679	33	9	cetuximab	cetuximab	VERB
bjp-14679	33	10	in	in	ADP
bjp-14679	33	11	gastric	gastric	ADJ
bjp-14679	33	12	cancer	cancer	NOUN
bjp-14679	33	13	cell	cell	NOUN
bjp-14679	33	14	lines	line	NOUN
bjp-14679	33	15	.	.	PUNCT
bjp-14679	34	1	cetuximab	cetuximab	NOUN
bjp-14679	34	2	monotherapy	monotherapy	NOUN
bjp-14679	34	3	has	have	VERB
bjp-14679	34	4	the	the	DET
bjp-14679	34	5	improved	improve	VERB
bjp-14679	34	6	treatment	treatment	NOUN
bjp-14679	34	7	outcome	outcome	NOUN
bjp-14679	34	8	compare	compare	VERB
bjp-14679	34	9	to	to	ADP
bjp-14679	34	10	other	other	ADJ
bjp-14679	34	11	chemotherapy	chemotherapy	NOUN
bjp-14679	34	12	drugs	drug	NOUN
bjp-14679	34	13	(	(	PUNCT
bjp-14679	34	14	heindl	heindl	NOUN
bjp-14679	34	15	et	et	PROPN
bjp-14679	34	16	al	al	PROPN
bjp-14679	34	17	.	.	PROPN
bjp-14679	34	18	,	,	PUNCT
bjp-14679	34	19	2012	2012	NUM
bjp-14679	34	20	)	)	PUNCT
bjp-14679	34	21	.	.	PUNCT
bjp-14679	35	1	by	by	ADP
bjp-14679	35	2	stimulating	stimulate	VERB
bjp-14679	35	3	an	an	DET
bjp-14679	35	4	immune	immune	ADJ
bjp-14679	35	5	system	system	NOUN
bjp-14679	35	6	mediated	mediate	VERB
bjp-14679	35	7	anti	anti	ADJ
bjp-14679	35	8	tumour	tumour	NOUN
bjp-14679	35	9	response	response	NOUN
bjp-14679	35	10	,	,	PUNCT
bjp-14679	35	11	cetuximab	cetuximab	NOUN
bjp-14679	35	12	inhibits	inhibit	VERB
bjp-14679	35	13	cancer	cancer	NOUN
bjp-14679	35	14	-	-	PUNCT
bjp-14679	35	15	cell	cell	NOUN
bjp-14679	35	16	proliferation	proliferation	NOUN
bjp-14679	35	17	,	,	PUNCT
bjp-14679	35	18	angiogenic	angiogenic	ADJ
bjp-14679	35	19	growth	growth	NOUN
bjp-14679	35	20	factor	factor	NOUN
bjp-14679	35	21	production	production	NOUN
bjp-14679	35	22	and	and	CCONJ
bjp-14679	35	23	tumor	tumor	NOUN
bjp-14679	35	24	-	-	PUNCT
bjp-14679	35	25	induced	induce	VERB
bjp-14679	35	26	angiogenesis	angiogenesis	NOUN
bjp-14679	35	27	,	,	PUNCT
bjp-14679	35	28	and	and	CCONJ
bjp-14679	35	29	cancer	cancer	NOUN
bjp-14679	35	30	cell	cell	NOUN
bjp-14679	35	31	invasion	invasion	NOUN
bjp-14679	35	32	.	.	PUNCT
bjp-14679	36	1	in	in	ADP
bjp-14679	36	2	gastric	gastric	ADJ
bjp-14679	36	3	cancer	cancer	NOUN
bjp-14679	36	4	treatment	treatment	NOUN
bjp-14679	36	5	,	,	PUNCT
bjp-14679	36	6	cetuximab	cetuximab	NOUN
bjp-14679	36	7	is	be	AUX
bjp-14679	36	8	over	over	ADV
bjp-14679	36	9	expressed	express	VERB
bjp-14679	36	10	with	with	ADP
bjp-14679	36	11	the	the	DET
bjp-14679	36	12	target	target	NOUN
bjp-14679	36	13	cells	cell	NOUN
bjp-14679	36	14	(	(	PUNCT
bjp-14679	36	15	lordick	lordick	PROPN
bjp-14679	36	16	et	et	PROPN
bjp-14679	36	17	al	al	PROPN
bjp-14679	36	18	.	.	PROPN
bjp-14679	36	19	,	,	PUNCT
bjp-14679	36	20	2010	2010	NUM
bjp-14679	36	21	)	)	PUNCT
bjp-14679	36	22	.	.	PUNCT
bjp-14679	37	1	the	the	DET
bjp-14679	37	2	literature	literature	NOUN
bjp-14679	37	3	evidences	evidence	NOUN
bjp-14679	37	4	indicates	indicate	VERB
bjp-14679	37	5	that	that	SCONJ
bjp-14679	37	6	mutation	mutation	NOUN
bjp-14679	37	7	in	in	ADP
bjp-14679	37	8	e	e	NOUN
bjp-14679	37	9	-	-	NOUN
bjp-14679	37	10	cadherin	cadherin	NOUN
bjp-14679	37	11	leads	lead	VERB
bjp-14679	37	12	to	to	ADP
bjp-14679	37	13	the	the	DET
bjp-14679	37	14	improper	improper	ADJ
bjp-14679	37	15	binding	binding	NOUN
bjp-14679	37	16	of	of	ADP
bjp-14679	37	17	cetuximab	cetuximab	NOUN
bjp-14679	37	18	and	and	CCONJ
bjp-14679	37	19	leads	lead	VERB
bjp-14679	37	20	to	to	ADP
bjp-14679	37	21	the	the	DET
bjp-14679	37	22	cetuximab	cetuximab	NOUN
bjp-14679	37	23	resistance	resistance	NOUN
bjp-14679	37	24	.	.	PUNCT
bjp-14679	38	1	therefore	therefore	ADV
bjp-14679	38	2	,	,	PUNCT
bjp-14679	38	3	monitoring	monitor	VERB
bjp-14679	38	4	the	the	DET
bjp-14679	38	5	cetuximab	cetuximab	NOUN
bjp-14679	38	6	resistance	resistance	NOUN
bjp-14679	38	7	is	be	AUX
bjp-14679	38	8	a	a	DET
bjp-14679	38	9	key	key	ADJ
bjp-14679	38	10	area	area	NOUN
bjp-14679	38	11	for	for	ADP
bjp-14679	38	12	the	the	DET
bjp-14679	38	13	treatment	treatment	NOUN
bjp-14679	38	14	of	of	ADP
bjp-14679	38	15	hdgc	hdgc	NOUN
bjp-14679	38	16	.	.	PUNCT
bjp-14679	39	1	this	this	PRON
bjp-14679	39	2	would	would	AUX
bjp-14679	39	3	be	be	AUX
bjp-14679	39	4	certainly	certainly	ADV
bjp-14679	39	5	helpful	helpful	ADJ
bjp-14679	39	6	for	for	ADP
bjp-14679	39	7	the	the	DET
bjp-14679	39	8	development	development	NOUN
bjp-14679	39	9	of	of	ADP
bjp-14679	39	10	long	long	ADJ
bjp-14679	39	11	acting	act	VERB
bjp-14679	39	12	drug	drug	NOUN
bjp-14679	39	13	molecule	molecule	NOUN
bjp-14679	39	14	.	.	PUNCT
bjp-14679	40	1	hence	hence	ADV
bjp-14679	40	2	,	,	PUNCT
bjp-14679	40	3	in	in	ADP
bjp-14679	40	4	this	this	DET
bjp-14679	40	5	present	present	ADJ
bjp-14679	40	6	study	study	NOUN
bjp-14679	40	7	,	,	PUNCT
bjp-14679	40	8	we	we	PRON
bjp-14679	40	9	identified	identify	VERB
bjp-14679	40	10	detrimental	detrimental	ADJ
bjp-14679	40	11	missense	missense	NOUN
bjp-14679	40	12	mutations	mutation	NOUN
bjp-14679	40	13	in	in	ADP
bjp-14679	40	14	e	e	NOUN
bjp-14679	40	15	-	-	NOUN
bjp-14679	40	16	cadherin	cadherin	NOUN
bjp-14679	40	17	using	use	VERB
bjp-14679	40	18	different	different	ADJ
bjp-14679	40	19	genomic	genomic	ADJ
bjp-14679	40	20	algorithms	algorithm	NOUN
bjp-14679	40	21	.	.	PUNCT
bjp-14679	41	1	subsequently	subsequently	ADV
bjp-14679	41	2	,	,	PUNCT
bjp-14679	41	3	the	the	DET
bjp-14679	41	4	sensitivity	sensitivity	NOUN
bjp-14679	41	5	of	of	ADP
bjp-14679	41	6	cetuximab	cetuximab	NOUN
bjp-14679	41	7	with	with	ADP
bjp-14679	41	8	mutated	mutate	VERB
bjp-14679	41	9	cells	cell	NOUN
bjp-14679	41	10	was	be	AUX
bjp-14679	41	11	also	also	ADV
bjp-14679	41	12	examined	examine	VERB
bjp-14679	41	13	by	by	ADP
bjp-14679	41	14	docking	dock	VERB
bjp-14679	41	15	analysis	analysis	NOUN
bjp-14679	41	16	.	.	PUNCT
bjp-14679	42	1	materials	material	NOUN
bjp-14679	42	2	and	and	CCONJ
bjp-14679	42	3	methods	method	NOUN
bjp-14679	42	4	the	the	DET
bjp-14679	42	5	snps	snps	PROPN
bjp-14679	42	6	(	(	PUNCT
bjp-14679	42	7	single	single	ADJ
bjp-14679	42	8	nucleotide	nucleotide	ADJ
bjp-14679	42	9	polymorphisms	polymorphism	NOUN
bjp-14679	42	10	)	)	PUNCT
bjp-14679	42	11	and	and	CCONJ
bjp-14679	42	12	their	their	PRON
bjp-14679	42	13	associated	associated	ADJ
bjp-14679	42	14	information	information	NOUN
bjp-14679	42	15	for	for	ADP
bjp-14679	42	16	cdh1	cdh1	NOUN
bjp-14679	42	17	gene	gene	NOUN
bjp-14679	42	18	were	be	AUX
bjp-14679	42	19	obtained	obtain	VERB
bjp-14679	42	20	from	from	ADP
bjp-14679	42	21	dbsnp	dbsnp	ADJ
bjp-14679	42	22	database	database	NOUN
bjp-14679	42	23	(	(	PUNCT
bjp-14679	42	24	http://www.ncbi.nlm.nih.gov/	http://www.ncbi.nlm.nih.gov/	ADV
bjp-14679	42	25	snp/	snp/	NOUN
bjp-14679	42	26	)	)	PUNCT
bjp-14679	42	27	for	for	ADP
bjp-14679	42	28	our	our	PRON
bjp-14679	42	29	computational	computational	ADJ
bjp-14679	42	30	analysis	analysis	NOUN
bjp-14679	42	31	.	.	PUNCT
bjp-14679	43	1	the	the	DET
bjp-14679	43	2	protein	protein	NOUN
bjp-14679	43	3	sequence	sequence	NOUN
bjp-14679	43	4	corresponds	correspond	VERB
bjp-14679	43	5	to	to	ADP
bjp-14679	43	6	e	e	NOUN
bjp-14679	43	7	-	-	NOUN
bjp-14679	43	8	cadherin	cadherin	NOUN
bjp-14679	43	9	were	be	AUX
bjp-14679	43	10	obtained	obtain	VERB
bjp-14679	43	11	from	from	ADP
bjp-14679	43	12	uniprot	uniprot	ADJ
bjp-14679	43	13	(	(	PUNCT
bjp-14679	43	14	http://www.uniprot.org/	http://www.uniprot.org/	NOUN
bjp-14679	43	15	)	)	PUNCT
bjp-14679	43	16	.	.	PUNCT
bjp-14679	44	1	the	the	DET
bjp-14679	44	2	3d	3d	PROPN
bjp-14679	44	3	structure	structure	NOUN
bjp-14679	44	4	of	of	ADP
bjp-14679	44	5	cdh1	cdh1	NOUN
bjp-14679	44	6	protein	protein	NOUN
bjp-14679	44	7	obtained	obtain	VERB
bjp-14679	44	8	from	from	ADP
bjp-14679	44	9	swissmodel	swissmodel	NOUN
bjp-14679	44	10	workspace	workspace	NOUN
bjp-14679	44	11	(	(	PUNCT
bjp-14679	44	12	arnold	arnold	PROPN
bjp-14679	44	13	et	et	PROPN
bjp-14679	44	14	al	al	PROPN
bjp-14679	44	15	.	.	PROPN
bjp-14679	44	16	,	,	PUNCT
bjp-14679	44	17	2006	2006	NUM
bjp-14679	44	18	)	)	PUNCT
bjp-14679	44	19	(	(	PUNCT
bjp-14679	44	20	http://	http://	PROPN
bjp-14679	44	21	swissmodel.expasy.org/	swissmodel.expasy.org/	NOUN
bjp-14679	44	22	)	)	PUNCT
bjp-14679	44	23	.	.	PUNCT
bjp-14679	45	1	the	the	DET
bjp-14679	45	2	mutant	mutant	ADJ
bjp-14679	45	3	structures	structure	NOUN
bjp-14679	45	4	were	be	AUX
bjp-14679	45	5	generated	generate	VERB
bjp-14679	45	6	by	by	ADP
bjp-14679	45	7	using	use	VERB
bjp-14679	45	8	spdb	spdb	ADJ
bjp-14679	45	9	viewer	viewer	NOUN
bjp-14679	45	10	package	package	NOUN
bjp-14679	45	11	.	.	PUNCT
bjp-14679	46	1	the	the	DET
bjp-14679	46	2	3d	3d	NUM
bjp-14679	46	3	structure	structure	NOUN
bjp-14679	46	4	of	of	ADP
bjp-14679	46	5	the	the	DET
bjp-14679	46	6	cetuximab	cetuximab	NOUN
bjp-14679	46	7	was	be	AUX
bjp-14679	46	8	retrieved	retrieve	VERB
bjp-14679	46	9	from	from	ADP
bjp-14679	46	10	protein	protein	NOUN
bjp-14679	46	11	data	datum	NOUN
bjp-14679	46	12	bank	bank	NOUN
bjp-14679	46	13	(	(	PUNCT
bjp-14679	46	14	berman	berman	PROPN
bjp-14679	46	15	et	et	PROPN
bjp-14679	46	16	al	al	PROPN
bjp-14679	46	17	.	.	PROPN
bjp-14679	46	18	,	,	PUNCT
bjp-14679	46	19	2000	2000	NUM
bjp-14679	46	20	)	)	PUNCT
bjp-14679	46	21	(	(	PUNCT
bjp-14679	46	22	http://	http://	PROPN
bjp-14679	46	23	www.rcsb.org/	www.rcsb.org/	PROPN
bjp-14679	46	24	)	)	PUNCT
bjp-14679	46	25	for	for	ADP
bjp-14679	46	26	the	the	DET
bjp-14679	46	27	molecular	molecular	ADJ
bjp-14679	46	28	docking	docking	NOUN
bjp-14679	46	29	analysis	analysis	NOUN
bjp-14679	46	30	.	.	PUNCT
bjp-14679	47	1	investigations	investigation	NOUN
bjp-14679	47	2	of	of	ADP
bjp-14679	47	3	structural	structural	ADJ
bjp-14679	47	4	and	and	CCONJ
bjp-14679	47	5	functional	functional	ADJ
bjp-14679	47	6	consequences	consequence	NOUN
bjp-14679	47	7	of	of	ADP
bjp-14679	47	8	coding	code	VERB
bjp-14679	47	9	nssnps	nssnps	NOUN
bjp-14679	47	10	by	by	ADP
bjp-14679	47	11	computational	computational	ADJ
bjp-14679	47	12	analysis	analysis	NOUN
bjp-14679	47	13	the	the	DET
bjp-14679	47	14	snp	snp	ADJ
bjp-14679	47	15	occurring	occur	VERB
bjp-14679	47	16	in	in	ADP
bjp-14679	47	17	the	the	DET
bjp-14679	47	18	protein	protein	NOUN
bjp-14679	47	19	coding	code	VERB
bjp-14679	47	20	region	region	NOUN
bjp-14679	47	21	normally	normally	ADV
bjp-14679	47	22	leads	lead	VERB
bjp-14679	47	23	to	to	ADP
bjp-14679	47	24	the	the	DET
bjp-14679	47	25	deleterious	deleterious	ADJ
bjp-14679	47	26	consequences	consequence	NOUN
bjp-14679	47	27	in	in	ADP
bjp-14679	47	28	its	its	PRON
bjp-14679	47	29	3d	3d	NOUN
bjp-14679	47	30	structure	structure	NOUN
bjp-14679	47	31	and	and	CCONJ
bjp-14679	47	32	hence	hence	ADV
bjp-14679	47	33	may	may	AUX
bjp-14679	47	34	prone	prone	VERB
bjp-14679	47	35	to	to	ADP
bjp-14679	47	36	disease	disease	NOUN
bjp-14679	47	37	-	-	PUNCT
bjp-14679	47	38	associated	associate	VERB
bjp-14679	47	39	phenomena	phenomenon	NOUN
bjp-14679	47	40	.	.	PUNCT
bjp-14679	48	1	in	in	ADP
bjp-14679	48	2	the	the	DET
bjp-14679	48	3	present	present	ADJ
bjp-14679	48	4	study	study	NOUN
bjp-14679	48	5	,	,	PUNCT
bjp-14679	48	6	we	we	PRON
bjp-14679	48	7	used	use	VERB
bjp-14679	48	8	the	the	DET
bjp-14679	48	9	genomic	genomic	ADJ
bjp-14679	48	10	tools	tool	NOUN
bjp-14679	48	11	such	such	ADJ
bjp-14679	48	12	as	as	ADP
bjp-14679	48	13	sift	sift	NOUN
bjp-14679	48	14	(	(	PUNCT
bjp-14679	48	15	ng	ng	PROPN
bjp-14679	48	16	and	and	CCONJ
bjp-14679	48	17	henikoff	henikoff	NOUN
bjp-14679	48	18	,	,	PUNCT
bjp-14679	48	19	2003	2003	NUM
bjp-14679	48	20	)	)	PUNCT
bjp-14679	48	21	,	,	PUNCT
bjp-14679	48	22	polyphen-2	polyphen-2	X
bjp-14679	48	23	(	(	PUNCT
bjp-14679	48	24	ramensky	ramensky	PROPN
bjp-14679	48	25	et	et	PROPN
bjp-14679	48	26	al	al	PROPN
bjp-14679	48	27	.	.	PROPN
bjp-14679	48	28	,	,	PUNCT
bjp-14679	48	29	2002	2002	NUM
bjp-14679	48	30	)	)	PUNCT
bjp-14679	48	31	,	,	PUNCT
bjp-14679	48	32	i	i	PRON
bjp-14679	48	33	-	-	PUNCT
bjp-14679	48	34	mutant2.0	mutant2.0	PROPN
bjp-14679	48	35	(	(	PUNCT
bjp-14679	48	36	capriotti	capriotti	PROPN
bjp-14679	48	37	et	et	PROPN
bjp-14679	48	38	al	al	PROPN
bjp-14679	48	39	.	.	PROPN
bjp-14679	48	40	,	,	PUNCT
bjp-14679	48	41	2005	2005	NUM
bjp-14679	48	42	)	)	PUNCT
bjp-14679	48	43	and	and	CCONJ
bjp-14679	48	44	snps	snps	PROPN
bjp-14679	48	45	&	&	CCONJ
bjp-14679	48	46	go	go	VERB
bjp-14679	48	47	(	(	PUNCT
bjp-14679	48	48	calabrese	calabrese	PROPN
bjp-14679	48	49	et	et	PROPN
bjp-14679	48	50	al	al	PROPN
bjp-14679	48	51	.	.	PROPN
bjp-14679	48	52	,	,	PUNCT
bjp-14679	48	53	2009	2009	NUM
bjp-14679	48	54	)	)	PUNCT
bjp-14679	48	55	to	to	PART
bjp-14679	48	56	detect	detect	VERB
bjp-14679	48	57	the	the	DET
bjp-14679	48	58	deleterious	deleterious	ADJ
bjp-14679	48	59	coding	code	VERB
bjp-14679	48	60	nssnps	nssnps	NOUN
bjp-14679	48	61	,	,	PUNCT
bjp-14679	48	62	and	and	CCONJ
bjp-14679	48	63	firedock	firedock	NOUN
bjp-14679	48	64	(	(	PUNCT
bjp-14679	48	65	mashiach	mashiach	PROPN
bjp-14679	48	66	et	et	PROPN
bjp-14679	48	67	al	al	PROPN
bjp-14679	48	68	.	.	PROPN
bjp-14679	48	69	,	,	PUNCT
bjp-14679	48	70	2008	2008	NUM
bjp-14679	48	71	)	)	PUNCT
bjp-14679	48	72	to	to	PART
bjp-14679	48	73	calculate	calculate	VERB
bjp-14679	48	74	the	the	DET
bjp-14679	48	75	binding	binding	ADJ
bjp-14679	48	76	free	free	ADJ
bjp-14679	48	77	energy	energy	NOUN
bjp-14679	48	78	.	.	PUNCT
bjp-14679	49	1	tolerance	tolerance	NOUN
bjp-14679	49	2	analysis	analysis	NOUN
bjp-14679	49	3	of	of	ADP
bjp-14679	49	4	missense	missense	NOUN
bjp-14679	49	5	mutations	mutation	NOUN
bjp-14679	49	6	by	by	ADP
bjp-14679	49	7	sift	sift	ADJ
bjp-14679	49	8	sift	sift	NOUN
bjp-14679	49	9	(	(	PUNCT
bjp-14679	49	10	sorting	sort	VERB
bjp-14679	49	11	intolerant	intolerant	ADJ
bjp-14679	49	12	from	from	ADP
bjp-14679	49	13	tolerant	tolerant	ADJ
bjp-14679	49	14	)	)	PUNCT
bjp-14679	49	15	is	be	AUX
bjp-14679	49	16	a	a	DET
bjp-14679	49	17	sequence	sequence	NOUN
bjp-14679	49	18	homology	homology	NOUN
bjp-14679	49	19	based	base	VERB
bjp-14679	49	20	tool	tool	NOUN
bjp-14679	49	21	available	available	ADJ
bjp-14679	49	22	at	at	ADP
bjp-14679	49	23	http://	http://	PROPN
bjp-14679	49	24	www.blocks.fhcrc.org/sift/sift.html	www.blocks.fhcrc.org/sift/sift.html	PUNCT
bjp-14679	49	25	.	.	PUNCT
bjp-14679	50	1	it	it	PRON
bjp-14679	50	2	presumes	presume	VERB
bjp-14679	50	3	that	that	SCONJ
bjp-14679	50	4	important	important	ADJ
bjp-14679	50	5	amino	amino	ADJ
bjp-14679	50	6	acids	acid	NOUN
bjp-14679	50	7	will	will	AUX
bjp-14679	50	8	be	be	AUX
bjp-14679	50	9	conserved	conserve	VERB
bjp-14679	50	10	in	in	ADP
bjp-14679	50	11	the	the	DET
bjp-14679	50	12	protein	protein	NOUN
bjp-14679	50	13	family	family	NOUN
bjp-14679	50	14	.	.	PUNCT
bjp-14679	51	1	thus	thus	ADV
bjp-14679	51	2	,	,	PUNCT
bjp-14679	51	3	changes	change	NOUN
bjp-14679	51	4	at	at	ADP
bjp-14679	51	5	well	well	ADV
bjp-14679	51	6	conserved	conserved	ADJ
bjp-14679	51	7	positions	position	NOUN
bjp-14679	51	8	tend	tend	VERB
bjp-14679	51	9	to	to	PART
bjp-14679	51	10	be	be	AUX
bjp-14679	51	11	predicted	predict	VERB
bjp-14679	51	12	as	as	ADP
bjp-14679	51	13	deleterious	deleterious	ADJ
bjp-14679	51	14	.	.	PUNCT
bjp-14679	52	1	we	we	PRON
bjp-14679	52	2	submitted	submit	VERB
bjp-14679	52	3	the	the	DET
bjp-14679	52	4	query	query	NOUN
bjp-14679	52	5	in	in	ADP
bjp-14679	52	6	the	the	DET
bjp-14679	52	7	form	form	NOUN
bjp-14679	52	8	of	of	ADP
bjp-14679	52	9	snp	snp	ADJ
bjp-14679	52	10	ids	id	NOUN
bjp-14679	52	11	or	or	CCONJ
bjp-14679	52	12	as	as	ADP
bjp-14679	52	13	protein	protein	NOUN
bjp-14679	52	14	sequences	sequence	NOUN
bjp-14679	52	15	.	.	PUNCT
bjp-14679	53	1	the	the	DET
bjp-14679	53	2	underlying	underlying	ADJ
bjp-14679	53	3	principle	principle	NOUN
bjp-14679	53	4	of	of	ADP
bjp-14679	53	5	this	this	DET
bjp-14679	53	6	program	program	NOUN
bjp-14679	53	7	is	be	AUX
bjp-14679	53	8	that	that	SCONJ
bjp-14679	53	9	sift	sift	NOUN
bjp-14679	53	10	takes	take	VERB
bjp-14679	53	11	a	a	DET
bjp-14679	53	12	query	query	NOUN
bjp-14679	53	13	sequence	sequence	NOUN
bjp-14679	53	14	and	and	CCONJ
bjp-14679	53	15	uses	use	VERB
bjp-14679	53	16	multiple	multiple	ADJ
bjp-14679	53	17	alignment	alignment	NOUN
bjp-14679	53	18	information	information	NOUN
bjp-14679	53	19	to	to	PART
bjp-14679	53	20	predict	predict	VERB
bjp-14679	53	21	tolerated	tolerate	VERB
bjp-14679	53	22	and	and	CCONJ
bjp-14679	53	23	deleterious	deleterious	ADJ
bjp-14679	53	24	substitutions	substitution	NOUN
bjp-14679	53	25	for	for	ADP
bjp-14679	53	26	every	every	DET
bjp-14679	53	27	position	position	NOUN
bjp-14679	53	28	of	of	ADP
bjp-14679	53	29	the	the	DET
bjp-14679	53	30	query	query	NOUN
bjp-14679	53	31	sequence	sequence	NOUN
bjp-14679	53	32	.	.	PUNCT
bjp-14679	54	1	sift	sift	PROPN
bjp-14679	54	2	is	be	AUX
bjp-14679	54	3	a	a	DET
bjp-14679	54	4	multistep	multistep	ADJ
bjp-14679	54	5	procedure	procedure	NOUN
bjp-14679	54	6	that	that	PRON
bjp-14679	54	7	,	,	PUNCT
bjp-14679	54	8	given	give	VERB
bjp-14679	54	9	a	a	DET
bjp-14679	54	10	protein	protein	NOUN
bjp-14679	54	11	sequence	sequence	NOUN
bjp-14679	54	12	,	,	PUNCT
bjp-14679	54	13	i	i	NOUN
bjp-14679	54	14	)	)	PUNCT
bjp-14679	54	15	searches	search	NOUN
bjp-14679	54	16	for	for	ADP
bjp-14679	54	17	similar	similar	ADJ
bjp-14679	54	18	sequences	sequence	NOUN
bjp-14679	54	19	,	,	PUNCT
bjp-14679	54	20	ii	ii	PROPN
bjp-14679	54	21	)	)	PUNCT
bjp-14679	54	22	chooses	choose	VERB
bjp-14679	54	23	closely	closely	ADV
bjp-14679	54	24	related	relate	VERB
bjp-14679	54	25	sequences	sequence	NOUN
bjp-14679	54	26	that	that	PRON
bjp-14679	54	27	may	may	AUX
bjp-14679	54	28	share	share	VERB
bjp-14679	54	29	similar	similar	ADJ
bjp-14679	54	30	functions	function	NOUN
bjp-14679	54	31	,	,	PUNCT
bjp-14679	54	32	iii	iii	X
bjp-14679	54	33	)	)	PUNCT
bjp-14679	54	34	obtains	obtain	VERB
bjp-14679	54	35	the	the	DET
bjp-14679	54	36	multiple	multiple	ADJ
bjp-14679	54	37	alignment	alignment	NOUN
bjp-14679	54	38	of	of	ADP
bjp-14679	54	39	the	the	DET
bjp-14679	54	40	chosen	choose	VERB
bjp-14679	54	41	sequences	sequence	NOUN
bjp-14679	54	42	,	,	PUNCT
bjp-14679	54	43	and	and	CCONJ
bjp-14679	54	44	iv	iv	X
bjp-14679	54	45	)	)	PUNCT
bjp-14679	54	46	calculates	calculate	NOUN
bjp-14679	54	47	normalized	normalize	VERB
bjp-14679	54	48	probabilities	probability	NOUN
bjp-14679	54	49	for	for	ADP
bjp-14679	54	50	all	all	DET
bjp-14679	54	51	possible	possible	ADJ
bjp-14679	54	52	substitutions	substitution	NOUN
bjp-14679	54	53	at	at	ADP
bjp-14679	54	54	each	each	DET
bjp-14679	54	55	position	position	NOUN
bjp-14679	54	56	from	from	ADP
bjp-14679	54	57	the	the	DET
bjp-14679	54	58	alignment	alignment	NOUN
bjp-14679	54	59	.	.	PUNCT
bjp-14679	55	1	substitutions	substitution	NOUN
bjp-14679	55	2	at	at	ADP
bjp-14679	55	3	each	each	DET
bjp-14679	55	4	position	position	NOUN
bjp-14679	55	5	which	which	PRON
bjp-14679	55	6	normalized	normalize	VERB
bjp-14679	55	7	probabilities	probability	NOUN
bjp-14679	55	8	less	less	ADJ
bjp-14679	55	9	than	than	ADP
bjp-14679	55	10	a	a	DET
bjp-14679	55	11	chosen	choose	VERB
bjp-14679	55	12	cutoff	cutoff	NOUN
bjp-14679	55	13	are	be	AUX
bjp-14679	55	14	predicted	predict	VERB
bjp-14679	55	15	to	to	PART
bjp-14679	55	16	be	be	AUX
bjp-14679	55	17	deleterious	deleterious	ADJ
bjp-14679	55	18	and	and	CCONJ
bjp-14679	55	19	those	those	PRON
bjp-14679	55	20	greater	great	ADJ
bjp-14679	55	21	than	than	ADP
bjp-14679	55	22	or	or	CCONJ
bjp-14679	55	23	equal	equal	ADJ
bjp-14679	55	24	to	to	ADP
bjp-14679	55	25	the	the	DET
bjp-14679	55	26	cutoff	cutoff	NOUN
bjp-14679	55	27	are	be	AUX
bjp-14679	55	28	predicted	predict	VERB
bjp-14679	55	29	to	to	PART
bjp-14679	55	30	be	be	AUX
bjp-14679	55	31	tolerated	tolerate	VERB
bjp-14679	55	32	(	(	PUNCT
bjp-14679	55	33	ng	ng	PROPN
bjp-14679	55	34	and	and	CCONJ
bjp-14679	55	35	henikoff	henikoff	NOUN
bjp-14679	55	36	,	,	PUNCT
bjp-14679	55	37	2003	2003	NUM
bjp-14679	55	38	)	)	PUNCT
bjp-14679	55	39	.	.	PUNCT
bjp-14679	56	1	the	the	DET
bjp-14679	56	2	cutoff	cutoff	NOUN
bjp-14679	56	3	value	value	NOUN
bjp-14679	56	4	in	in	ADP
bjp-14679	56	5	the	the	DET
bjp-14679	56	6	sift	sift	PROPN
bjp-14679	56	7	program	program	NOUN
bjp-14679	56	8	is	be	AUX
bjp-14679	56	9	a	a	DET
bjp-14679	56	10	tolerance	tolerance	NOUN
bjp-14679	56	11	index	index	NOUN
bjp-14679	56	12	of	of	ADP
bjp-14679	56	13	≥0.05	≥0.05	PROPN
bjp-14679	56	14	.	.	PUNCT
bjp-14679	57	1	the	the	PRON
bjp-14679	57	2	higher	high	ADJ
bjp-14679	57	3	the	the	DET
bjp-14679	57	4	tolerance	tolerance	NOUN
bjp-14679	57	5	index	index	NOUN
bjp-14679	57	6	,	,	PUNCT
bjp-14679	57	7	the	the	DET
bjp-14679	57	8	less	less	ADV
bjp-14679	57	9	function	function	NOUN
bjp-14679	57	10	impact	impact	NOUN
bjp-14679	57	11	a	a	DET
bjp-14679	57	12	particular	particular	ADJ
bjp-14679	57	13	amino	amino	NOUN
bjp-14679	57	14	acid	acid	NOUN
bjp-14679	57	15	substitution	substitution	NOUN
bjp-14679	57	16	is	be	AUX
bjp-14679	57	17	likely	likely	ADJ
bjp-14679	57	18	to	to	PART
bjp-14679	57	19	have	have	VERB
bjp-14679	57	20	.	.	PUNCT
bjp-14679	57	21	prediction	prediction	NOUN
bjp-14679	57	22	by	by	ADP
bjp-14679	57	23	polyphen-2	polyphen-2	PRON
bjp-14679	57	24	the	the	DET
bjp-14679	57	25	structural	structural	ADJ
bjp-14679	57	26	level	level	NOUN
bjp-14679	57	27	analysis	analysis	NOUN
bjp-14679	57	28	of	of	ADP
bjp-14679	57	29	coding	code	VERB
bjp-14679	57	30	nssnps	nssnps	NOUN
bjp-14679	57	31	at	at	ADP
bjp-14679	57	32	is	be	AUX
bjp-14679	57	33	considered	consider	VERB
bjp-14679	57	34	to	to	PART
bjp-14679	57	35	be	be	AUX
bjp-14679	57	36	very	very	ADV
bjp-14679	57	37	important	important	ADJ
bjp-14679	57	38	to	to	PART
bjp-14679	57	39	understand	understand	VERB
bjp-14679	57	40	the	the	DET
bjp-14679	57	41	functional	functional	ADJ
bjp-14679	57	42	activity	activity	NOUN
bjp-14679	57	43	of	of	ADP
bjp-14679	57	44	the	the	DET
bjp-14679	57	45	protein	protein	NOUN
bjp-14679	57	46	.	.	PUNCT
bjp-14679	58	1	in	in	ADP
bjp-14679	58	2	the	the	DET
bjp-14679	58	3	present	present	ADJ
bjp-14679	58	4	study	study	NOUN
bjp-14679	58	5	,	,	PUNCT
bjp-14679	58	6	structural	structural	ADJ
bjp-14679	58	7	level	level	NOUN
bjp-14679	58	8	analysis	analysis	NOUN
bjp-14679	58	9	was	be	AUX
bjp-14679	58	10	performed	perform	VERB
bjp-14679	58	11	with	with	ADP
bjp-14679	58	12	the	the	DET
bjp-14679	58	13	aid	aid	NOUN
bjp-14679	58	14	of	of	ADP
bjp-14679	58	15	polyphen-2	polyphen-2	X
bjp-14679	58	16	(	(	PUNCT
bjp-14679	58	17	ramensky	ramensky	PROPN
bjp-14679	58	18	et	et	PROPN
bjp-14679	58	19	al	al	PROPN
bjp-14679	58	20	.	.	PROPN
bjp-14679	58	21	,	,	PUNCT
bjp-14679	58	22	2002	2002	NUM
bjp-14679	58	23	)	)	PUNCT
bjp-14679	58	24	,	,	PUNCT
bjp-14679	58	25	which	which	PRON
bjp-14679	58	26	is	be	AUX
bjp-14679	58	27	available	available	ADJ
bjp-14679	58	28	at	at	ADP
bjp-14679	58	29	http://coot.embl.de/polyphen/.	http://coot.embl.de/polyphen/.	PROPN
bjp-14679	58	30	input	input	NOUN
bjp-14679	58	31	options	option	NOUN
bjp-14679	58	32	for	for	ADP
bjp-14679	58	33	the	the	DET
bjp-14679	58	34	polyphen-2	polyphen-2	NUM
bjp-14679	58	35	program	program	NOUN
bjp-14679	58	36	are	be	AUX
bjp-14679	58	37	protein	protein	NOUN
bjp-14679	58	38	sequence	sequence	NOUN
bjp-14679	58	39	or	or	CCONJ
bjp-14679	58	40	accession	accession	NOUN
bjp-14679	58	41	number	number	NOUN
bjp-14679	58	42	together	together	ADV
bjp-14679	58	43	with	with	ADP
bjp-14679	58	44	sequence	sequence	NOUN
bjp-14679	58	45	position	position	NOUN
bjp-14679	58	46	with	with	ADP
bjp-14679	58	47	two	two	NUM
bjp-14679	58	48	amino	amino	ADJ
bjp-14679	58	49	acid	acid	NOUN
bjp-14679	58	50	variants	variant	NOUN
bjp-14679	58	51	.	.	PUNCT
bjp-14679	59	1	we	we	PRON
bjp-14679	59	2	submitted	submit	VERB
bjp-14679	59	3	the	the	DET
bjp-14679	59	4	query	query	NOUN
bjp-14679	59	5	in	in	ADP
bjp-14679	59	6	the	the	DET
bjp-14679	59	7	form	form	NOUN
bjp-14679	59	8	of	of	ADP
bjp-14679	59	9	protein	protein	NOUN
bjp-14679	59	10	sequence	sequence	NOUN
bjp-14679	59	11	with	with	ADP
bjp-14679	59	12	mutational	mutational	ADJ
bjp-14679	59	13	position	position	NOUN
bjp-14679	59	14	and	and	CCONJ
bjp-14679	59	15	two	two	NUM
bjp-14679	59	16	amino	amino	ADJ
bjp-14679	59	17	acid	acid	NOUN
bjp-14679	59	18	variants	variant	NOUN
bjp-14679	59	19	.	.	PUNCT
bjp-14679	60	1	sequence	sequence	NOUN
bjp-14679	60	2	based	base	VERB
bjp-14679	60	3	characterization	characterization	NOUN
bjp-14679	60	4	of	of	ADP
bjp-14679	60	5	the	the	DET
bjp-14679	60	6	substitution	substitution	NOUN
bjp-14679	60	7	site	site	NOUN
bjp-14679	60	8	,	,	PUNCT
bjp-14679	60	9	profile	profile	VERB
bjp-14679	60	10	analysis	analysis	NOUN
bjp-14679	60	11	of	of	ADP
bjp-14679	60	12	homologous	homologous	ADJ
bjp-14679	60	13	sequences	sequence	NOUN
bjp-14679	60	14	,	,	PUNCT
bjp-14679	60	15	and	and	CCONJ
bjp-14679	60	16	mapping	mapping	NOUN
bjp-14679	60	17	of	of	ADP
bjp-14679	60	18	substitution	substitution	NOUN
bjp-14679	60	19	site	site	NOUN
bjp-14679	60	20	to	to	ADP
bjp-14679	60	21	a	a	DET
bjp-14679	60	22	known	know	VERB
bjp-14679	60	23	protein	protein	NOUN
bjp-14679	60	24	three	three	NUM
bjp-14679	60	25	dimensional	dimensional	ADJ
bjp-14679	60	26	structure	structure	NOUN
bjp-14679	60	27	are	be	AUX
bjp-14679	60	28	the	the	DET
bjp-14679	60	29	parameters	parameter	NOUN
bjp-14679	60	30	taken	take	VERB
bjp-14679	60	31	into	into	ADP
bjp-14679	60	32	account	account	NOUN
bjp-14679	60	33	by	by	ADP
bjp-14679	60	34	the	the	DET
bjp-14679	60	35	polyphen-2	polyphen-2	NUM
bjp-14679	60	36	program	program	NOUN
bjp-14679	60	37	to	to	PART
bjp-14679	60	38	calculate	calculate	VERB
bjp-14679	60	39	the	the	DET
bjp-14679	60	40	score	score	NOUN
bjp-14679	60	41	.	.	PUNCT
bjp-14679	61	1	it	it	PRON
bjp-14679	61	2	calculates	calculate	VERB
bjp-14679	61	3	psic	psic	ADJ
bjp-14679	61	4	scores	score	NOUN
bjp-14679	61	5	for	for	ADP
bjp-14679	61	6	each	each	PRON
bjp-14679	61	7	of	of	ADP
bjp-14679	61	8	the	the	DET
bjp-14679	61	9	two	two	NUM
bjp-14679	61	10	variants	variant	NOUN
bjp-14679	61	11	and	and	CCONJ
bjp-14679	61	12	then	then	ADV
bjp-14679	61	13	computes	compute	VERB
bjp-14679	61	14	the	the	DET
bjp-14679	61	15	difference	difference	NOUN
bjp-14679	61	16	between	between	ADP
bjp-14679	61	17	them	they	PRON
bjp-14679	61	18	.	.	PUNCT
bjp-14679	62	1	the	the	PRON
bjp-14679	62	2	higher	high	ADJ
bjp-14679	62	3	the	the	DET
bjp-14679	62	4	psic	psic	ADJ
bjp-14679	62	5	score	score	NOUN
bjp-14679	62	6	difference	difference	NOUN
bjp-14679	62	7	,	,	PUNCT
bjp-14679	62	8	the	the	DET
bjp-14679	62	9	higher	high	ADJ
bjp-14679	62	10	is	be	AUX
bjp-14679	62	11	the	the	DET
bjp-14679	62	12	possible	possible	ADJ
bjp-14679	62	13	functional	functional	ADJ
bjp-14679	62	14	impact	impact	NOUN
bjp-14679	62	15	of	of	ADP
bjp-14679	62	16	a	a	DET
bjp-14679	62	17	particular	particular	ADJ
bjp-14679	62	18	amino	amino	NOUN
bjp-14679	62	19	acid	acid	NOUN
bjp-14679	62	20	substitution	substitution	NOUN
bjp-14679	62	21	.	.	PUNCT
bjp-14679	63	1	stability	stability	NOUN
bjp-14679	63	2	analysis	analysis	NOUN
bjp-14679	63	3	with	with	ADP
bjp-14679	63	4	i	i	PROPN
bjp-14679	63	5	-	-	PUNCT
bjp-14679	63	6	mutant2.0	mutant2.0	PROPN
bjp-14679	63	7	i	i	PRON
bjp-14679	63	8	-	-	PUNCT
bjp-14679	63	9	mutant2.0	mutant2.0	PROPN
bjp-14679	63	10	is	be	AUX
bjp-14679	63	11	a	a	DET
bjp-14679	63	12	support	support	NOUN
bjp-14679	63	13	vector	vector	NOUN
bjp-14679	63	14	machine	machine	NOUN
bjp-14679	63	15	(	(	PUNCT
bjp-14679	63	16	svm	svm	PROPN
bjp-14679	63	17	)	)	PUNCT
bjp-14679	63	18	based	base	VERB
bjp-14679	63	19	tool	tool	NOUN
bjp-14679	63	20	for	for	ADP
bjp-14679	63	21	the	the	DET
bjp-14679	63	22	automatic	automatic	ADJ
bjp-14679	63	23	prediction	prediction	NOUN
bjp-14679	63	24	of	of	ADP
bjp-14679	63	25	protein	protein	NOUN
bjp-14679	63	26	stability	stability	NOUN
bjp-14679	63	27	changes	change	NOUN
bjp-14679	63	28	caused	cause	VERB
bjp-14679	63	29	by	by	ADP
bjp-14679	63	30	single	single	ADJ
bjp-14679	63	31	point	point	NOUN
bjp-14679	63	32	mutations	mutation	NOUN
bjp-14679	63	33	.	.	PUNCT
bjp-14679	64	1	the	the	DET
bjp-14679	64	2	predictions	prediction	NOUN
bjp-14679	64	3	were	be	AUX
bjp-14679	64	4	performed	perform	VERB
bjp-14679	64	5	starting	start	VERB
bjp-14679	64	6	either	either	CCONJ
bjp-14679	64	7	from	from	ADP
bjp-14679	64	8	the	the	DET
bjp-14679	64	9	protein	protein	NOUN
bjp-14679	64	10	structure	structure	NOUN
bjp-14679	64	11	or	or	CCONJ
bjp-14679	64	12	,	,	PUNCT
bjp-14679	64	13	more	more	ADV
bjp-14679	64	14	importantly	importantly	ADV
bjp-14679	64	15	,	,	PUNCT
bjp-14679	64	16	from	from	ADP
bjp-14679	64	17	the	the	DET
bjp-14679	64	18	protein	protein	NOUN
bjp-14679	64	19	sequence	sequence	NOUN
bjp-14679	64	20	(	(	PUNCT
bjp-14679	64	21	capriotti	capriotti	NOUN
bjp-14679	64	22	et	et	PROPN
bjp-14679	64	23	al	al	PROPN
bjp-14679	64	24	.	.	PROPN
bjp-14679	64	25	,	,	PUNCT
bjp-14679	64	26	2005	2005	NUM
bjp-14679	64	27	)	)	PUNCT
bjp-14679	64	28	.	.	PUNCT
bjp-14679	65	1	the	the	DET
bjp-14679	65	2	output	output	NOUN
bjp-14679	65	3	files	file	NOUN
bjp-14679	65	4	show	show	VERB
bjp-14679	65	5	the	the	DET
bjp-14679	65	6	predicted	predict	VERB
bjp-14679	65	7	free	free	ADJ
bjp-14679	65	8	energy	energy	NOUN
bjp-14679	65	9	change	change	NOUN
bjp-14679	65	10	value	value	NOUN
bjp-14679	65	11	(	(	PUNCT
bjp-14679	65	12	δδg	δδg	PROPN
bjp-14679	65	13	)	)	PUNCT
bjp-14679	65	14	,	,	PUNCT
bjp-14679	65	15	which	which	PRON
bjp-14679	65	16	was	be	AUX
bjp-14679	65	17	calculated	calculate	VERB
bjp-14679	65	18	from	from	ADP
bjp-14679	65	19	the	the	DET
bjp-14679	65	20	unfolding	unfolding	NOUN
bjp-14679	65	21	gibbs	gibbs	PROPN
bjp-14679	65	22	free	free	ADJ
bjp-14679	65	23	energy	energy	NOUN
bjp-14679	65	24	value	value	NOUN
bjp-14679	65	25	of	of	ADP
bjp-14679	65	26	the	the	DET
bjp-14679	65	27	mutated	mutate	VERB
bjp-14679	65	28	protein	protein	NOUN
bjp-14679	65	29	minus	minus	ADP
bjp-14679	65	30	the	the	DET
bjp-14679	65	31	unfolding	unfold	VERB
bjp-14679	65	32	gibbs	gibbs	PROPN
bjp-14679	65	33	free	free	ADJ
bjp-14679	65	34	energy	energy	NOUN
bjp-14679	65	35	value	value	NOUN
bjp-14679	65	36	of	of	ADP
bjp-14679	65	37	the	the	DET
bjp-14679	65	38	native	native	ADJ
bjp-14679	65	39	protein	protein	NOUN
bjp-14679	65	40	(	(	PUNCT
bjp-14679	65	41	kcal	kcal	PROPN
bjp-14679	65	42	/	/	SYM
bjp-14679	65	43	mol	mol	NOUN
bjp-14679	65	44	)	)	PUNCT
bjp-14679	65	45	.	.	PUNCT
bjp-14679	66	1	positive	positive	ADJ
bjp-14679	66	2	δδg	δδg	NOUN
bjp-14679	66	3	values	value	NOUN
bjp-14679	66	4	meant	mean	VERB
bjp-14679	66	5	that	that	SCONJ
bjp-14679	66	6	the	the	DET
bjp-14679	66	7	mutated	mutate	VERB
bjp-14679	66	8	protein	protein	NOUN
bjp-14679	66	9	has	have	VERB
bjp-14679	66	10	higher	high	ADJ
bjp-14679	66	11	stability	stability	NOUN
bjp-14679	66	12	and	and	CCONJ
bjp-14679	66	13	negative	negative	ADJ
bjp-14679	66	14	values	value	NOUN
bjp-14679	66	15	are	be	AUX
bjp-14679	66	16	the	the	DET
bjp-14679	66	17	indication	indication	NOUN
bjp-14679	66	18	of	of	ADP
bjp-14679	66	19	lesser	less	ADJ
bjp-14679	66	20	stability	stability	NOUN
bjp-14679	66	21	.	.	PUNCT
bjp-14679	67	1	prediction	prediction	NOUN
bjp-14679	67	2	of	of	ADP
bjp-14679	67	3	disease	disease	NOUN
bjp-14679	67	4	related	relate	VERB
bjp-14679	67	5	mutations	mutation	NOUN
bjp-14679	67	6	using	use	VERB
bjp-14679	67	7	snps	snps	PROPN
bjp-14679	67	8	&	&	CCONJ
bjp-14679	67	9	208	208	NUM
bjp-14679	67	10	bangladesh	bangladesh	PROPN
bjp-14679	67	11	j	j	PROPN
bjp-14679	67	12	pharmacol	pharmacol	PROPN
bjp-14679	67	13	2013	2013	NUM
bjp-14679	67	14	;	;	PUNCT
bjp-14679	67	15	8	8	NUM
bjp-14679	67	16	:	:	SYM
bjp-14679	67	17	207	207	NUM
bjp-14679	67	18	-	-	SYM
bjp-14679	67	19	213	213	NUM
bjp-14679	67	20	go	go	VERB
bjp-14679	67	21	furthermore	furthermore	ADV
bjp-14679	67	22	,	,	PUNCT
bjp-14679	67	23	we	we	PRON
bjp-14679	67	24	have	have	AUX
bjp-14679	67	25	used	use	VERB
bjp-14679	67	26	single	single	ADJ
bjp-14679	67	27	nucleotide	nucleotide	NOUN
bjp-14679	67	28	polymorphism	polymorphism	NOUN
bjp-14679	67	29	database	database	NOUN
bjp-14679	67	30	(	(	PUNCT
bjp-14679	67	31	snps	snps	PROPN
bjp-14679	67	32	)	)	PUNCT
bjp-14679	67	33	&	&	CCONJ
bjp-14679	67	34	gene	gene	NOUN
bjp-14679	67	35	ontology	ontology	NOUN
bjp-14679	67	36	(	(	PUNCT
bjp-14679	67	37	go	go	VERB
bjp-14679	67	38	)	)	PUNCT
bjp-14679	67	39	are	be	AUX
bjp-14679	67	40	support	support	NOUN
bjp-14679	67	41	vector	vector	NOUN
bjp-14679	67	42	machine	machine	NOUN
bjp-14679	67	43	(	(	PUNCT
bjp-14679	67	44	svm	svm	PROPN
bjp-14679	67	45	)	)	PUNCT
bjp-14679	67	46	based	base	VERB
bjp-14679	67	47	accurate	accurate	ADJ
bjp-14679	67	48	methods	method	NOUN
bjp-14679	67	49	used	use	VERB
bjp-14679	67	50	to	to	PART
bjp-14679	67	51	predict	predict	VERB
bjp-14679	67	52	the	the	DET
bjp-14679	67	53	disease	disease	NOUN
bjp-14679	67	54	related	relate	VERB
bjp-14679	67	55	mutations	mutation	NOUN
bjp-14679	67	56	from	from	ADP
bjp-14679	67	57	protein	protein	NOUN
bjp-14679	67	58	sequences	sequence	NOUN
bjp-14679	67	59	with	with	ADP
bjp-14679	67	60	a	a	DET
bjp-14679	67	61	scoring	scoring	NOUN
bjp-14679	67	62	accuracy	accuracy	NOUN
bjp-14679	67	63	of	of	ADP
bjp-14679	67	64	82	82	NUM
bjp-14679	67	65	%	%	NOUN
bjp-14679	67	66	and	and	CCONJ
bjp-14679	67	67	matthews	matthews	NOUN
bjp-14679	67	68	correlation	correlation	NOUN
bjp-14679	67	69	coefficient	coefficient	NOUN
bjp-14679	67	70	of	of	ADP
bjp-14679	67	71	0.63	0.63	NUM
bjp-14679	67	72	(	(	PUNCT
bjp-14679	67	73	calabrese	calabrese	PROPN
bjp-14679	67	74	et	et	PROPN
bjp-14679	67	75	al	al	PROPN
bjp-14679	67	76	.	.	PROPN
bjp-14679	67	77	,	,	PUNCT
bjp-14679	67	78	2009	2009	NUM
bjp-14679	67	79	)	)	PUNCT
bjp-14679	67	80	.	.	PUNCT
bjp-14679	68	1	the	the	DET
bjp-14679	68	2	fasta	fasta	PROPN
bjp-14679	68	3	sequence	sequence	NOUN
bjp-14679	68	4	of	of	ADP
bjp-14679	68	5	whole	whole	ADJ
bjp-14679	68	6	protein	protein	NOUN
bjp-14679	68	7	is	be	AUX
bjp-14679	68	8	considered	consider	VERB
bjp-14679	68	9	to	to	PART
bjp-14679	68	10	be	be	AUX
bjp-14679	68	11	an	an	DET
bjp-14679	68	12	input	input	NOUN
bjp-14679	68	13	option	option	NOUN
bjp-14679	68	14	and	and	CCONJ
bjp-14679	68	15	output	output	NOUN
bjp-14679	68	16	will	will	AUX
bjp-14679	68	17	be	be	AUX
bjp-14679	68	18	the	the	DET
bjp-14679	68	19	prediction	prediction	NOUN
bjp-14679	68	20	results	result	NOUN
bjp-14679	68	21	based	base	VERB
bjp-14679	68	22	on	on	ADP
bjp-14679	68	23	the	the	DET
bjp-14679	68	24	discrimination	discrimination	NOUN
bjp-14679	68	25	among	among	ADP
bjp-14679	68	26	disease	disease	NOUN
bjp-14679	68	27	related	relate	VERB
bjp-14679	68	28	and	and	CCONJ
bjp-14679	68	29	neutral	neutral	ADJ
bjp-14679	68	30	variations	variation	NOUN
bjp-14679	68	31	of	of	ADP
bjp-14679	68	32	protein	protein	NOUN
bjp-14679	68	33	sequence	sequence	NOUN
bjp-14679	68	34	.	.	PUNCT
bjp-14679	69	1	the	the	DET
bjp-14679	69	2	ri	ri	PROPN
bjp-14679	69	3	(	(	PUNCT
bjp-14679	69	4	reliability	reliability	NOUN
bjp-14679	69	5	index	index	NOUN
bjp-14679	69	6	)	)	PUNCT
bjp-14679	69	7	higher	high	ADJ
bjp-14679	69	8	than	than	ADP
bjp-14679	69	9	5	5	NUM
bjp-14679	69	10	reveals	reveal	VERB
bjp-14679	69	11	the	the	DET
bjp-14679	69	12	disease	disease	NOUN
bjp-14679	69	13	related	relate	VERB
bjp-14679	69	14	effect	effect	NOUN
bjp-14679	69	15	of	of	ADP
bjp-14679	69	16	mutation	mutation	NOUN
bjp-14679	69	17	on	on	ADP
bjp-14679	69	18	the	the	DET
bjp-14679	69	19	parent	parent	NOUN
bjp-14679	69	20	protein	protein	NOUN
bjp-14679	69	21	function	function	NOUN
bjp-14679	69	22	.	.	PUNCT
bjp-14679	70	1	homology	homology	NOUN
bjp-14679	70	2	modelling	modelling	NOUN
bjp-14679	70	3	and	and	CCONJ
bjp-14679	70	4	rmsd	rmsd	VERB
bjp-14679	70	5	analysis	analysis	NOUN
bjp-14679	70	6	the	the	DET
bjp-14679	70	7	sequence	sequence	NOUN
bjp-14679	70	8	version	version	NOUN
bjp-14679	70	9	of	of	ADP
bjp-14679	70	10	the	the	DET
bjp-14679	70	11	human	human	ADJ
bjp-14679	70	12	e	e	PROPN
bjp-14679	70	13	-	-	NOUN
bjp-14679	70	14	cadherin	cadherin	NOUN
bjp-14679	70	15	protein	protein	NOUN
bjp-14679	70	16	was	be	AUX
bjp-14679	70	17	retrieved	retrieve	VERB
bjp-14679	70	18	from	from	ADP
bjp-14679	70	19	swiss	swiss	ADJ
bjp-14679	70	20	-prot	-prot	NOUN
bjp-14679	70	21	(	(	PUNCT
bjp-14679	70	22	http://	http://	PROPN
bjp-14679	70	23	www.expasy.ch/sprot/	www.expasy.ch/sprot/	PROPN
bjp-14679	70	24	)	)	PUNCT
bjp-14679	70	25	.	.	PUNCT
bjp-14679	71	1	then	then	ADV
bjp-14679	71	2	a	a	DET
bjp-14679	71	3	blast	blast	NOUN
bjp-14679	71	4	(	(	PUNCT
bjp-14679	71	5	http://	http://	PROPN
bjp-14679	71	6	www.ncbi.nlm.nih.gov/blast/	www.ncbi.nlm.nih.gov/blast/	PROPN
bjp-14679	71	7	)	)	PUNCT
bjp-14679	71	8	sequence	sequence	NOUN
bjp-14679	71	9	analysis	analysis	NOUN
bjp-14679	71	10	was	be	AUX
bjp-14679	71	11	performed	perform	VERB
bjp-14679	71	12	against	against	ADP
bjp-14679	71	13	the	the	DET
bjp-14679	71	14	whole	whole	ADJ
bjp-14679	71	15	pdb	pdb	NOUN
bjp-14679	71	16	to	to	PART
bjp-14679	71	17	select	select	VERB
bjp-14679	71	18	the	the	DET
bjp-14679	71	19	template	template	NOUN
bjp-14679	71	20	that	that	PRON
bjp-14679	71	21	could	could	AUX
bjp-14679	71	22	be	be	AUX
bjp-14679	71	23	used	use	VERB
bjp-14679	71	24	to	to	PART
bjp-14679	71	25	generate	generate	VERB
bjp-14679	71	26	the	the	DET
bjp-14679	71	27	model	model	NOUN
bjp-14679	71	28	of	of	ADP
bjp-14679	71	29	e	e	NOUN
bjp-14679	71	30	-	-	NOUN
bjp-14679	71	31	cadherin	cadherin	NOUN
bjp-14679	71	32	.	.	PUNCT
bjp-14679	72	1	subsequently	subsequently	ADV
bjp-14679	72	2	,	,	PUNCT
bjp-14679	72	3	the	the	DET
bjp-14679	72	4	three	three	NUM
bjp-14679	72	5	dimensional	dimensional	ADJ
bjp-14679	72	6	structure	structure	NOUN
bjp-14679	72	7	of	of	ADP
bjp-14679	72	8	the	the	DET
bjp-14679	72	9	model	model	NOUN
bjp-14679	72	10	for	for	ADP
bjp-14679	72	11	the	the	DET
bjp-14679	72	12	e	e	NOUN
bjp-14679	72	13	-	-	NOUN
bjp-14679	72	14	cadherin	cadherin	NOUN
bjp-14679	72	15	was	be	AUX
bjp-14679	72	16	generated	generate	VERB
bjp-14679	72	17	by	by	ADP
bjp-14679	72	18	the	the	DET
bjp-14679	72	19	homology	homology	NOUN
bjp-14679	72	20	modeling	model	VERB
bjp-14679	72	21	software	software	NOUN
bjp-14679	72	22	from	from	ADP
bjp-14679	72	23	the	the	DET
bjp-14679	72	24	swissmodel	swissmodel	NOUN
bjp-14679	72	25	workspace	workspace	NOUN
bjp-14679	72	26	(	(	PUNCT
bjp-14679	72	27	http://swissmodel.expasy.org/	http://swissmodel.expasy.org/	NOUN
bjp-14679	72	28	)	)	PUNCT
bjp-14679	72	29	.	.	PUNCT
bjp-14679	73	1	furthermore	furthermore	ADV
bjp-14679	73	2	,	,	PUNCT
bjp-14679	73	3	the	the	DET
bjp-14679	73	4	mutated	mutate	VERB
bjp-14679	73	5	model	model	NOUN
bjp-14679	73	6	structure	structure	NOUN
bjp-14679	73	7	was	be	AUX
bjp-14679	73	8	generated	generate	VERB
bjp-14679	73	9	by	by	ADP
bjp-14679	73	10	means	mean	NOUN
bjp-14679	73	11	of	of	ADP
bjp-14679	73	12	swisspdb	swisspdb	ADJ
bjp-14679	73	13	viewer	viewer	NOUN
bjp-14679	73	14	.	.	PUNCT
bjp-14679	74	1	we	we	PRON
bjp-14679	74	2	used	use	VERB
bjp-14679	74	3	conjugate	conjugate	ADJ
bjp-14679	74	4	gradient	gradient	NOUN
bjp-14679	74	5	method	method	NOUN
bjp-14679	74	6	for	for	ADP
bjp-14679	74	7	optimizing	optimize	VERB
bjp-14679	74	8	the	the	DET
bjp-14679	74	9	3d	3d	PROPN
bjp-14679	74	10	structures	structure	NOUN
bjp-14679	74	11	.	.	PUNCT
bjp-14679	75	1	the	the	DET
bjp-14679	75	2	deviation	deviation	NOUN
bjp-14679	75	3	between	between	ADP
bjp-14679	75	4	the	the	DET
bjp-14679	75	5	two	two	NUM
bjp-14679	75	6	structures	structure	NOUN
bjp-14679	75	7	was	be	AUX
bjp-14679	75	8	evaluated	evaluate	VERB
bjp-14679	75	9	by	by	ADP
bjp-14679	75	10	their	their	PRON
bjp-14679	75	11	root	root	NOUN
bjp-14679	75	12	mean	mean	ADJ
bjp-14679	75	13	square	square	ADJ
bjp-14679	75	14	deviation	deviation	NOUN
bjp-14679	75	15	(	(	PUNCT
bjp-14679	75	16	rmsd	rmsd	NOUN
bjp-14679	75	17	)	)	PUNCT
bjp-14679	75	18	analysis	analysis	NOUN
bjp-14679	75	19	.	.	PUNCT
bjp-14679	76	1	molecular	molecular	ADJ
bjp-14679	76	2	docking	docking	NOUN
bjp-14679	76	3	studies	study	NOUN
bjp-14679	76	4	the	the	DET
bjp-14679	76	5	firedock	firedock	NOUN
bjp-14679	76	6	(	(	PUNCT
bjp-14679	76	7	mashiach	mashiach	PROPN
bjp-14679	76	8	et	et	PROPN
bjp-14679	76	9	al	al	PROPN
bjp-14679	76	10	.	.	PROPN
bjp-14679	76	11	,	,	PUNCT
bjp-14679	76	12	2008	2008	NUM
bjp-14679	76	13	)	)	PUNCT
bjp-14679	76	14	,	,	PUNCT
bjp-14679	76	15	fast	fast	ADJ
bjp-14679	76	16	interaction	interaction	NOUN
bjp-14679	76	17	refinement	refinement	NOUN
bjp-14679	76	18	in	in	ADP
bjp-14679	76	19	molecular	molecular	ADJ
bjp-14679	76	20	docking	docking	NOUN
bjp-14679	76	21	algorithm	algorithm	NOUN
bjp-14679	76	22	was	be	AUX
bjp-14679	76	23	used	use	VERB
bjp-14679	76	24	to	to	PART
bjp-14679	76	25	calculate	calculate	VERB
bjp-14679	76	26	the	the	DET
bjp-14679	76	27	binding	bind	VERB
bjp-14679	76	28	affinity	affinity	NOUN
bjp-14679	76	29	of	of	ADP
bjp-14679	76	30	cetuximab	cetuximab	NOUN
bjp-14679	76	31	with	with	ADP
bjp-14679	76	32	ecadherin	ecadherin	NOUN
bjp-14679	76	33	.	.	PUNCT
bjp-14679	77	1	this	this	DET
bjp-14679	77	2	program	program	NOUN
bjp-14679	77	3	is	be	AUX
bjp-14679	77	4	available	available	ADJ
bjp-14679	77	5	at	at	ADP
bjp-14679	77	6	http://	http://	PROPN
bjp-14679	77	7	www.bioinfo3d.cs.tau.ac.il/firedock/index.html	www.bioinfo3d.cs.tau.ac.il/firedock/index.html	PROPN
bjp-14679	77	8	.	.	PUNCT
bjp-14679	78	1	the	the	DET
bjp-14679	78	2	method	method	NOUN
bjp-14679	78	3	simultaneously	simultaneously	ADV
bjp-14679	78	4	targets	target	VERB
bjp-14679	78	5	the	the	DET
bjp-14679	78	6	problem	problem	NOUN
bjp-14679	78	7	of	of	ADP
bjp-14679	78	8	flexibility	flexibility	NOUN
bjp-14679	78	9	and	and	CCONJ
bjp-14679	78	10	scoring	scoring	NOUN
bjp-14679	78	11	of	of	ADP
bjp-14679	78	12	solutions	solution	NOUN
bjp-14679	78	13	produced	produce	VERB
bjp-14679	78	14	by	by	ADP
bjp-14679	78	15	fast	fast	ADJ
bjp-14679	78	16	rigidbody	rigidbody	NOUN
bjp-14679	78	17	docking	dock	VERB
bjp-14679	78	18	algorithms	algorithm	NOUN
bjp-14679	78	19	.	.	PUNCT
bjp-14679	79	1	given	give	VERB
bjp-14679	79	2	a	a	DET
bjp-14679	79	3	set	set	NOUN
bjp-14679	79	4	of	of	ADP
bjp-14679	79	5	up	up	ADP
bjp-14679	79	6	to	to	PART
bjp-14679	79	7	1000	1000	NUM
bjp-14679	79	8	potential	potential	ADJ
bjp-14679	79	9	docking	docking	NOUN
bjp-14679	79	10	candidates	candidate	NOUN
bjp-14679	79	11	,	,	PUNCT
bjp-14679	79	12	firedock	firedock	NOUN
bjp-14679	79	13	refines	refine	NOUN
bjp-14679	79	14	and	and	CCONJ
bjp-14679	79	15	scores	score	NOUN
bjp-14679	79	16	them	they	PRON
bjp-14679	79	17	according	accord	VERB
bjp-14679	79	18	to	to	ADP
bjp-14679	79	19	an	an	DET
bjp-14679	79	20	energy	energy	NOUN
bjp-14679	79	21	function	function	NOUN
bjp-14679	79	22	,	,	PUNCT
bjp-14679	79	23	spending	spend	VERB
bjp-14679	79	24	about	about	ADP
bjp-14679	79	25	3.5	3.5	NUM
bjp-14679	79	26	seconds	second	NOUN
bjp-14679	79	27	per	per	ADP
bjp-14679	79	28	candidate	candidate	NOUN
bjp-14679	79	29	solution	solution	NOUN
bjp-14679	79	30	.	.	PUNCT
bjp-14679	80	1	the	the	DET
bjp-14679	80	2	candidate	candidate	NOUN
bjp-14679	80	3	solutions	solution	NOUN
bjp-14679	80	4	for	for	ADP
bjp-14679	80	5	firedock	firedock	NOUN
bjp-14679	80	6	can	can	AUX
bjp-14679	80	7	be	be	AUX
bjp-14679	80	8	generated	generate	VERB
bjp-14679	80	9	by	by	ADP
bjp-14679	80	10	rigid	rigid	ADJ
bjp-14679	80	11	-	-	PUNCT
bjp-14679	80	12	body	body	NOUN
bjp-14679	80	13	docking	docking	NOUN
bjp-14679	80	14	methods	method	NOUN
bjp-14679	80	15	,	,	PUNCT
bjp-14679	80	16	such	such	ADJ
bjp-14679	80	17	as	as	ADP
bjp-14679	80	18	patchdock	patchdock	NOUN
bjp-14679	80	19	,	,	PUNCT
bjp-14679	80	20	fft	fft	NOUN
bjp-14679	80	21	-	-	PUNCT
bjp-14679	80	22	based	base	VERB
bjp-14679	80	23	methods	method	NOUN
bjp-14679	80	24	such	such	ADJ
bjp-14679	80	25	as	as	ADP
bjp-14679	80	26	zdock	zdock	NOUN
bjp-14679	80	27	,	,	PUNCT
bjp-14679	80	28	gramm	gramm	PROPN
bjp-14679	80	29	-	-	PUNCT
bjp-14679	80	30	x	x	PROPN
bjp-14679	80	31	,	,	PUNCT
bjp-14679	80	32	hex	hex	PROPN
bjp-14679	80	33	,	,	PUNCT
bjp-14679	80	34	cluspro	cluspro	ADJ
bjp-14679	80	35	etc	etc	X
bjp-14679	80	36	.	.	PUNCT
bjp-14679	81	1	the	the	DET
bjp-14679	81	2	output	output	NOUN
bjp-14679	81	3	is	be	AUX
bjp-14679	81	4	a	a	DET
bjp-14679	81	5	table	table	NOUN
bjp-14679	81	6	of	of	ADP
bjp-14679	81	7	ranked	rank	VERB
bjp-14679	81	8	global	global	ADJ
bjp-14679	81	9	energy	energy	NOUN
bjp-14679	81	10	values	value	NOUN
bjp-14679	81	11	.	.	PUNCT
bjp-14679	82	1	the	the	DET
bjp-14679	82	2	refined	refined	ADJ
bjp-14679	82	3	complex	complex	ADJ
bjp-14679	82	4	structure	structure	NOUN
bjp-14679	82	5	is	be	AUX
bjp-14679	82	6	generated	generate	VERB
bjp-14679	82	7	for	for	ADP
bjp-14679	82	8	up	up	ADP
bjp-14679	82	9	to	to	PART
bjp-14679	82	10	100	100	NUM
bjp-14679	82	11	low	low	ADJ
bjp-14679	82	12	-	-	PUNCT
bjp-14679	82	13	energy	energy	NOUN
bjp-14679	82	14	candidates	candidate	NOUN
bjp-14679	82	15	.	.	PUNCT
bjp-14679	83	1	results	result	NOUN
bjp-14679	83	2	and	and	CCONJ
bjp-14679	83	3	discussion	discussion	NOUN
bjp-14679	83	4	there	there	PRON
bjp-14679	83	5	are	be	VERB
bjp-14679	83	6	68	68	NUM
bjp-14679	83	7	missense	missense	NOUN
bjp-14679	83	8	mutations	mutation	NOUN
bjp-14679	83	9	,	,	PUNCT
bjp-14679	83	10	namely	namely	ADV
bjp-14679	83	11	m203v	m203v	PROPN
bjp-14679	83	12	,	,	PUNCT
bjp-14679	83	13	r29q	r29q	NOUN
bjp-14679	83	14	,	,	PUNCT
bjp-14679	83	15	v153i	v153i	PROPN
bjp-14679	83	16	,	,	PUNCT
bjp-14679	83	17	t211p	t211p	PROPN
bjp-14679	83	18	,	,	PUNCT
bjp-14679	83	19	w483s	w483s	PROPN
bjp-14679	83	20	,	,	PUNCT
bjp-14679	83	21	n155s	n155s	PROPN
bjp-14679	83	22	,	,	PUNCT
bjp-14679	83	23	r162w	r162w	PROPN
bjp-14679	83	24	,	,	PUNCT
bjp-14679	83	25	r28w	r28w	NOUN
bjp-14679	83	26	,	,	PUNCT
bjp-14679	83	27	v138	v138	PROPN
bjp-14679	83	28	m	m	PROPN
bjp-14679	83	29	,	,	PUNCT
bjp-14679	83	30	a80	a80	PROPN
bjp-14679	83	31	t	t	PROPN
bjp-14679	83	32	,	,	PUNCT
bjp-14679	83	33	r169h	r169h	PROPN
bjp-14679	83	34	,	,	PUNCT
bjp-14679	83	35	m177	m177	PROPN
bjp-14679	83	36	t	t	PROPN
bjp-14679	83	37	,	,	PUNCT
bjp-14679	83	38	k69	k69	PROPN
bjp-14679	83	39	t	t	PROPN
bjp-14679	83	40	,	,	PUNCT
bjp-14679	83	41	c306r	c306r	PROPN
bjp-14679	83	42	,	,	PUNCT
bjp-14679	83	43	e336d	e336d	PROPN
bjp-14679	83	44	,	,	PUNCT
bjp-14679	83	45	n674y	n674y	PROPN
bjp-14679	83	46	,	,	PUNCT
bjp-14679	83	47	p597s	p597s	PROPN
bjp-14679	83	48	,	,	PUNCT
bjp-14679	83	49	r224h	r224h	PROPN
bjp-14679	83	50	,	,	PUNCT
bjp-14679	83	51	k182n	k182n	PROPN
bjp-14679	83	52	,	,	PUNCT
bjp-14679	83	53	t395a	t395a	PROPN
bjp-14679	83	54	,	,	PUNCT
bjp-14679	83	55	m282i	m282i	PROPN
bjp-14679	83	56	,	,	PUNCT
bjp-14679	83	57	g879s	g879s	PROPN
bjp-14679	83	58	,	,	PUNCT
bjp-14679	83	59	d805n	d805n	PROPN
bjp-14679	83	60	,	,	PUNCT
bjp-14679	83	61	k184i	k184i	PROPN
bjp-14679	83	62	,	,	PUNCT
bjp-14679	83	63	r224c	r224c	PROPN
bjp-14679	83	64	,	,	PUNCT
bjp-14679	83	65	d882n	d882n	PROPN
bjp-14679	83	66	,	,	PUNCT
bjp-14679	83	67	d443n	d443n	PROPN
bjp-14679	83	68	,	,	PUNCT
bjp-14679	83	69	e410k	e410k	PROPN
bjp-14679	83	70	,	,	PUNCT
bjp-14679	83	71	y755c	y755c	PROPN
bjp-14679	83	72	,	,	PUNCT
bjp-14679	83	73	a401d	a401d	PROPN
bjp-14679	83	74	,	,	PUNCT
bjp-14679	83	75	n666h	n666h	PROPN
bjp-14679	83	76	,	,	PUNCT
bjp-14679	83	77	e702k	e702k	NOUN
bjp-14679	83	78	,	,	PUNCT
bjp-14679	83	79	s543f	s543f	NOUN
bjp-14679	83	80	,	,	PUNCT
bjp-14679	83	81	n622s	n622s	PROPN
bjp-14679	83	82	,	,	PUNCT
bjp-14679	83	83	p201r	p201r	PROPN
bjp-14679	83	84	,	,	PUNCT
bjp-14679	83	85	i535v	i535v	PROPN
bjp-14679	83	86	,	,	PUNCT
bjp-14679	83	87	k381n	k381n	PROPN
bjp-14679	83	88	,	,	PUNCT
bjp-14679	83	89	e864k	e864k	PROPN
bjp-14679	83	90	,	,	PUNCT
bjp-14679	83	91	a298	a298	PROPN
bjp-14679	83	92	t	t	PROPN
bjp-14679	83	93	,	,	PUNCT
bjp-14679	83	94	v132i	v132i	PROPN
bjp-14679	83	95	,	,	PUNCT
bjp-14679	83	96	v392i	v392i	PROPN
bjp-14679	83	97	,	,	PUNCT
bjp-14679	83	98	d768n	d768n	PROPN
bjp-14679	83	99	,	,	PUNCT
bjp-14679	83	100	p30	p30	PROPN
bjp-14679	83	101	t	t	PROPN
bjp-14679	83	102	,	,	PUNCT
bjp-14679	83	103	a788v	a788v	PROPN
bjp-14679	83	104	,	,	PUNCT
bjp-14679	83	105	a408v	a408v	PROPN
bjp-14679	83	106	,	,	PUNCT
bjp-14679	83	107	a709s	a709s	PROPN
bjp-14679	83	108	,	,	PUNCT
bjp-14679	83	109	a634v	a634v	PROPN
bjp-14679	83	110	,	,	PUNCT
bjp-14679	83	111	s838	s838	PROPN
bjp-14679	83	112	g	g	NOUN
bjp-14679	83	113	,	,	PUNCT
bjp-14679	83	114	l711v	l711v	PROPN
bjp-14679	83	115	,	,	PUNCT
bjp-14679	83	116	t340a	t340a	PROPN
bjp-14679	83	117	,	,	PUNCT
bjp-14679	83	118	v574f	v574f	PROPN
bjp-14679	83	119	,	,	PUNCT
bjp-14679	83	120	r124h	r124h	PROPN
bjp-14679	83	121	,	,	PUNCT
bjp-14679	83	122	d676n	d676n	PROPN
bjp-14679	83	123	,	,	PUNCT
bjp-14679	83	124	t506a	t506a	PROPN
bjp-14679	83	125	,	,	PUNCT
bjp-14679	83	126	v242i	v242i	PROPN
bjp-14679	83	127	,	,	PUNCT
bjp-14679	83	128	t340	t340	PROPN
bjp-14679	83	129	m	m	PROPN
bjp-14679	83	130	,	,	PUNCT
bjp-14679	83	131	d498e	d498e	PROPN
bjp-14679	83	132	,	,	PUNCT
bjp-14679	83	133	v473i	v473i	NOUN
bjp-14679	83	134	,	,	PUNCT
bjp-14679	83	135	d72n	d72n	PROPN
bjp-14679	83	136	,	,	PUNCT
bjp-14679	83	137	v832	v832	PROPN
bjp-14679	83	138	m	m	PROPN
bjp-14679	83	139	,	,	PUNCT
bjp-14679	83	140	l478p	l478p	PROPN
bjp-14679	83	141	,	,	PUNCT
bjp-14679	83	142	a592	a592	PROPN
bjp-14679	83	143	t	t	PROPN
bjp-14679	83	144	,	,	PUNCT
bjp-14679	83	145	e880k	e880k	PROPN
bjp-14679	83	146	,	,	PUNCT
bjp-14679	83	147	i393n	i393n	PROPN
bjp-14679	83	148	,	,	PUNCT
bjp-14679	83	149	n751k	n751k	PROPN
bjp-14679	83	150	,	,	PUNCT
bjp-14679	83	151	a617	a617	PROPN
bjp-14679	83	152	t	t	PROPN
bjp-14679	83	153	,	,	PUNCT
bjp-14679	83	154	c695r	c695r	PROPN
bjp-14679	83	155	,	,	PUNCT
bjp-14679	83	156	l630v	l630v	PROPN
bjp-14679	83	157	were	be	AUX
bjp-14679	83	158	examined	examine	VERB
bjp-14679	83	159	in	in	ADP
bjp-14679	83	160	this	this	DET
bjp-14679	83	161	work	work	NOUN
bjp-14679	83	162	retrieved	retrieve	VERB
bjp-14679	83	163	from	from	ADP
bjp-14679	83	164	dbsnp	dbsnp	ADJ
bjp-14679	83	165	(	(	PUNCT
bjp-14679	83	166	smigielski	smigielski	PROPN
bjp-14679	83	167	et	et	PROPN
bjp-14679	83	168	al	al	PROPN
bjp-14679	83	169	.	.	PROPN
bjp-14679	83	170	,	,	PUNCT
bjp-14679	83	171	2000	2000	NUM
bjp-14679	83	172	)	)	PUNCT
bjp-14679	83	173	.	.	PUNCT
bjp-14679	84	1	the	the	DET
bjp-14679	84	2	mutations	mutation	NOUN
bjp-14679	84	3	were	be	AUX
bjp-14679	84	4	independently	independently	ADV
bjp-14679	84	5	submitted	submit	VERB
bjp-14679	84	6	into	into	ADP
bjp-14679	84	7	sift	sift	ADJ
bjp-14679	84	8	program	program	NOUN
bjp-14679	84	9	to	to	PART
bjp-14679	84	10	check	check	VERB
bjp-14679	84	11	its	its	PRON
bjp-14679	84	12	tolerance	tolerance	NOUN
bjp-14679	84	13	index	index	NOUN
bjp-14679	84	14	(	(	PUNCT
bjp-14679	84	15	ng	ng	PROPN
bjp-14679	84	16	and	and	CCONJ
bjp-14679	84	17	henikoff	henikoff	NOUN
bjp-14679	84	18	,	,	PUNCT
bjp-14679	84	19	2003	2003	NUM
bjp-14679	84	20	)	)	PUNCT
bjp-14679	84	21	.	.	PUNCT
bjp-14679	85	1	among	among	ADP
bjp-14679	85	2	the	the	DET
bjp-14679	85	3	68	68	NUM
bjp-14679	85	4	variants	variant	NOUN
bjp-14679	85	5	,	,	PUNCT
bjp-14679	85	6	24	24	NUM
bjp-14679	85	7	variants	variant	NOUN
bjp-14679	85	8	found	find	VERB
bjp-14679	85	9	to	to	PART
bjp-14679	85	10	be	be	AUX
bjp-14679	85	11	deleterious	deleterious	ADJ
bjp-14679	85	12	having	have	VERB
bjp-14679	85	13	the	the	DET
bjp-14679	85	14	tolerance	tolerance	NOUN
bjp-14679	85	15	index	index	NOUN
bjp-14679	85	16	score	score	NOUN
bjp-14679	85	17	of	of	ADP
bjp-14679	85	18	≤0.05	≤0.05	NOUN
bjp-14679	85	19	.	.	PUNCT
bjp-14679	86	1	the	the	DET
bjp-14679	86	2	result	result	NOUN
bjp-14679	86	3	is	be	AUX
bjp-14679	86	4	shown	show	VERB
bjp-14679	86	5	in	in	ADP
bjp-14679	86	6	table	table	NOUN
bjp-14679	86	7	i.	i.	NOUN
bjp-14679	86	8	we	we	PRON
bjp-14679	86	9	observer	observer	VERB
bjp-14679	86	10	that	that	SCONJ
bjp-14679	86	11	,	,	PUNCT
bjp-14679	86	12	out	out	ADP
bjp-14679	86	13	of	of	ADP
bjp-14679	86	14	24	24	NUM
bjp-14679	86	15	variants	variant	NOUN
bjp-14679	86	16	8	8	NUM
bjp-14679	86	17	variants	variant	NOUN
bjp-14679	86	18	were	be	AUX
bjp-14679	86	19	having	have	VERB
bjp-14679	86	20	highly	highly	ADV
bjp-14679	86	21	deleterious	deleterious	ADJ
bjp-14679	86	22	tolerance	tolerance	NOUN
bjp-14679	86	23	score	score	NOUN
bjp-14679	86	24	0	0	NUM
bjp-14679	86	25	.	.	X
bjp-14679	87	1	six	six	NUM
bjp-14679	87	2	variants	variant	NOUN
bjp-14679	87	3	were	be	AUX
bjp-14679	87	4	having	have	VERB
bjp-14679	87	5	tolerance	tolerance	NOUN
bjp-14679	87	6	index	index	NOUN
bjp-14679	87	7	score	score	NOUN
bjp-14679	87	8	of	of	ADP
bjp-14679	87	9	0.01	0.01	NUM
bjp-14679	87	10	,	,	PUNCT
bjp-14679	87	11	four	four	NUM
bjp-14679	87	12	variants	variant	NOUN
bjp-14679	87	13	were	be	AUX
bjp-14679	87	14	having	have	VERB
bjp-14679	87	15	tolerance	tolerance	NOUN
bjp-14679	87	16	index	index	NOUN
bjp-14679	87	17	score	score	NOUN
bjp-14679	87	18	of	of	ADP
bjp-14679	87	19	0.02	0.02	NUM
bjp-14679	87	20	,	,	PUNCT
bjp-14679	87	21	one	one	NUM
bjp-14679	87	22	variant	variant	NOUN
bjp-14679	87	23	had	have	VERB
bjp-14679	87	24	a	a	DET
bjp-14679	87	25	tolerance	tolerance	NOUN
bjp-14679	87	26	index	index	NOUN
bjp-14679	87	27	score	score	NOUN
bjp-14679	87	28	of	of	ADP
bjp-14679	87	29	0.03	0.03	NUM
bjp-14679	87	30	,	,	PUNCT
bjp-14679	87	31	four	four	NUM
bjp-14679	87	32	variants	variant	NOUN
bjp-14679	87	33	were	be	AUX
bjp-14679	87	34	having	have	VERB
bjp-14679	87	35	tolerance	tolerance	NOUN
bjp-14679	87	36	index	index	NOUN
bjp-14679	87	37	score	score	NOUN
bjp-14679	87	38	of	of	ADP
bjp-14679	87	39	0.04	0.04	NUM
bjp-14679	87	40	and	and	CCONJ
bjp-14679	87	41	one	one	NUM
bjp-14679	87	42	variant	variant	NOUN
bjp-14679	87	43	had	have	VERB
bjp-14679	87	44	a	a	DET
bjp-14679	87	45	tolerance	tolerance	NOUN
bjp-14679	87	46	index	index	NOUN
bjp-14679	87	47	score	score	NOUN
bjp-14679	87	48	of	of	ADP
bjp-14679	87	49	0.05	0.05	NUM
bjp-14679	87	50	.	.	PUNCT
bjp-14679	88	1	protein	protein	NOUN
bjp-14679	88	2	sequence	sequence	NOUN
bjp-14679	88	3	with	with	ADP
bjp-14679	88	4	mutational	mutational	ADJ
bjp-14679	88	5	position	position	NOUN
bjp-14679	88	6	and	and	CCONJ
bjp-14679	88	7	amino	amino	NOUN
bjp-14679	88	8	acid	acid	NOUN
bjp-14679	88	9	variants	variant	NOUN
bjp-14679	88	10	associated	associate	VERB
bjp-14679	88	11	with	with	ADP
bjp-14679	88	12	68	68	NUM
bjp-14679	88	13	single	single	ADJ
bjp-14679	88	14	point	point	NOUN
bjp-14679	88	15	mutants	mutant	NOUN
bjp-14679	88	16	,	,	PUNCT
bjp-14679	88	17	used	use	VERB
bjp-14679	88	18	in	in	ADP
bjp-14679	88	19	this	this	DET
bjp-14679	88	20	work	work	NOUN
bjp-14679	88	21	were	be	AUX
bjp-14679	88	22	submitted	submit	VERB
bjp-14679	88	23	as	as	ADP
bjp-14679	88	24	input	input	NOUN
bjp-14679	88	25	to	to	ADP
bjp-14679	88	26	the	the	DET
bjp-14679	88	27	polyphen	polyphen	ADJ
bjp-14679	88	28	program	program	NOUN
bjp-14679	88	29	(	(	PUNCT
bjp-14679	88	30	ramensky	ramensky	PROPN
bjp-14679	88	31	et	et	PROPN
bjp-14679	88	32	al	al	PROPN
bjp-14679	88	33	.	.	PROPN
bjp-14679	88	34	,	,	PUNCT
bjp-14679	88	35	2002	2002	NUM
bjp-14679	88	36	)	)	PUNCT
bjp-14679	88	37	and	and	CCONJ
bjp-14679	88	38	results	result	NOUN
bjp-14679	88	39	were	be	AUX
bjp-14679	88	40	shown	show	VERB
bjp-14679	88	41	in	in	ADP
bjp-14679	88	42	table	table	NOUN
bjp-14679	88	43	i.	i.	NOUN
bjp-14679	88	44	a	a	DET
bjp-14679	88	45	psic	psic	ADJ
bjp-14679	88	46	score	score	NOUN
bjp-14679	88	47	difference	difference	NOUN
bjp-14679	88	48	of	of	ADP
bjp-14679	88	49	1.5	1.5	NUM
bjp-14679	88	50	and	and	CCONJ
bjp-14679	88	51	above	above	ADV
bjp-14679	88	52	was	be	AUX
bjp-14679	88	53	considered	consider	VERB
bjp-14679	88	54	to	to	PART
bjp-14679	88	55	be	be	AUX
bjp-14679	88	56	damaging	damaging	ADJ
bjp-14679	88	57	.	.	PUNCT
bjp-14679	89	1	out	out	ADP
bjp-14679	89	2	of	of	ADP
bjp-14679	89	3	68	68	NUM
bjp-14679	89	4	variants	variant	NOUN
bjp-14679	89	5	23	23	NUM
bjp-14679	89	6	variants	variant	NOUN
bjp-14679	89	7	were	be	AUX
bjp-14679	89	8	considered	consider	VERB
bjp-14679	89	9	to	to	PART
bjp-14679	89	10	be	be	AUX
bjp-14679	89	11	damaging	damage	VERB
bjp-14679	89	12	by	by	ADP
bjp-14679	89	13	polyphen	polyphen	ADJ
bjp-14679	89	14	program	program	NOUN
bjp-14679	89	15	.	.	PUNCT
bjp-14679	90	1	interestingly	interestingly	ADV
bjp-14679	90	2	13	13	NUM
bjp-14679	90	3	variants	variant	NOUN
bjp-14679	90	4	namely	namely	ADV
bjp-14679	90	5	,	,	PUNCT
bjp-14679	90	6	r162w	r162w	PROPN
bjp-14679	90	7	,	,	PUNCT
bjp-14679	90	8	r169h	r169h	PROPN
bjp-14679	90	9	,	,	PUNCT
bjp-14679	90	10	n674y	n674y	PROPN
bjp-14679	90	11	,	,	PUNCT
bjp-14679	90	12	e336d	e336d	PROPN
bjp-14679	90	13	,	,	PUNCT
bjp-14679	90	14	a298	a298	PROPN
bjp-14679	90	15	t	t	PROPN
bjp-14679	90	16	,	,	PUNCT
bjp-14679	90	17	p201r	p201r	PROPN
bjp-14679	90	18	,	,	PUNCT
bjp-14679	90	19	c695r	c695r	PROPN
bjp-14679	90	20	,	,	PUNCT
bjp-14679	90	21	g879s	g879s	PROPN
bjp-14679	90	22	,	,	PUNCT
bjp-14679	90	23	d882n	d882n	PROPN
bjp-14679	90	24	,	,	PUNCT
bjp-14679	90	25	y755c	y755c	PROPN
bjp-14679	90	26	,	,	PUNCT
bjp-14679	90	27	d768n	d768n	PROPN
bjp-14679	90	28	,	,	PUNCT
bjp-14679	90	29	i393n	i393n	PROPN
bjp-14679	90	30	and	and	CCONJ
bjp-14679	90	31	n751k	n751k	PROPN
bjp-14679	90	32	were	be	AUX
bjp-14679	90	33	considered	consider	VERB
bjp-14679	90	34	to	to	PART
bjp-14679	90	35	be	be	AUX
bjp-14679	90	36	damaging	damage	VERB
bjp-14679	90	37	by	by	ADP
bjp-14679	90	38	polyphen	polyphen	ADV
bjp-14679	90	39	also	also	ADV
bjp-14679	90	40	were	be	AUX
bjp-14679	90	41	seen	see	VERB
bjp-14679	90	42	to	to	PART
bjp-14679	90	43	be	be	AUX
bjp-14679	90	44	deleterious	deleterious	ADJ
bjp-14679	90	45	according	accord	VERB
bjp-14679	90	46	to	to	ADP
bjp-14679	90	47	the	the	DET
bjp-14679	90	48	sift	sift	PROPN
bjp-14679	90	49	program	program	NOUN
bjp-14679	90	50	.	.	PUNCT
bjp-14679	91	1	to	to	PART
bjp-14679	91	2	further	far	ADV
bjp-14679	91	3	probe	probe	VERB
bjp-14679	91	4	this	this	DET
bjp-14679	91	5	behaviour	behaviour	NOUN
bjp-14679	91	6	,	,	PUNCT
bjp-14679	91	7	we	we	PRON
bjp-14679	91	8	used	use	VERB
bjp-14679	91	9	i	i	PRON
bjp-14679	91	10	-	-	PUNCT
bjp-14679	91	11	mutant	mutant	ADJ
bjp-14679	91	12	2.0	2.0	NUM
bjp-14679	91	13	program	program	NOUN
bjp-14679	91	14	for	for	ADP
bjp-14679	91	15	our	our	PRON
bjp-14679	91	16	analysis	analysis	NOUN
bjp-14679	91	17	.	.	PUNCT
bjp-14679	92	1	this	this	DET
bjp-14679	92	2	program	program	NOUN
bjp-14679	92	3	predicts	predict	VERB
bjp-14679	92	4	the	the	DET
bjp-14679	92	5	stability	stability	NOUN
bjp-14679	92	6	to	to	ADP
bjp-14679	92	7	the	the	DET
bjp-14679	92	8	protein	protein	NOUN
bjp-14679	92	9	structure	structure	NOUN
bjp-14679	92	10	by	by	ADP
bjp-14679	92	11	means	mean	NOUN
bjp-14679	92	12	of	of	ADP
bjp-14679	92	13			ADV
bjp-14679	92	14	g	g	NOUN
bjp-14679	92	15	value	value	NOUN
bjp-14679	92	16	.	.	PUNCT
bjp-14679	93	1	out	out	ADP
bjp-14679	93	2	of	of	ADP
bjp-14679	93	3	68	68	NUM
bjp-14679	93	4	variants	variant	NOUN
bjp-14679	93	5	,	,	PUNCT
bjp-14679	93	6	we	we	PRON
bjp-14679	93	7	obtained	obtain	VERB
bjp-14679	93	8	53	53	NUM
bjp-14679	93	9	variants	variant	NOUN
bjp-14679	93	10	found	find	VERB
bjp-14679	93	11	to	to	PART
bjp-14679	93	12	be	be	AUX
bjp-14679	93	13	less	less	ADV
bjp-14679	93	14	stable	stable	ADJ
bjp-14679	93	15	from	from	ADP
bjp-14679	93	16	the	the	DET
bjp-14679	93	17	i	i	NOUN
bjp-14679	93	18	-	-	PUNCT
bjp-14679	93	19	mutant	mutant	ADJ
bjp-14679	93	20	2.0	2.0	NUM
bjp-14679	93	21	program	program	NOUN
bjp-14679	93	22	(	(	PUNCT
bjp-14679	93	23	capriotti	capriotti	NOUN
bjp-14679	93	24	et	et	PROPN
bjp-14679	93	25	al	al	PROPN
bjp-14679	93	26	.	.	PROPN
bjp-14679	93	27	,	,	PUNCT
bjp-14679	93	28	2005	2005	NUM
bjp-14679	93	29	)	)	PUNCT
bjp-14679	93	30	as	as	SCONJ
bjp-14679	93	31	shown	show	VERB
bjp-14679	93	32	in	in	ADP
bjp-14679	93	33	table	table	NOUN
bjp-14679	93	34	i.	i.	NOUN
bjp-14679	93	35	it	it	PRON
bjp-14679	93	36	is	be	AUX
bjp-14679	93	37	interesting	interesting	ADJ
bjp-14679	93	38	to	to	PART
bjp-14679	93	39	observe	observe	VERB
bjp-14679	93	40	that	that	SCONJ
bjp-14679	93	41	5	5	NUM
bjp-14679	93	42	variants	variant	NOUN
bjp-14679	93	43	showed	show	VERB
bjp-14679	93	44	a	a	DET
bjp-14679	93	45			ADV
bjp-14679	93	46	g	g	NOUN
bjp-14679	93	47	value	value	NOUN
bjp-14679	93	48	of	of	ADP
bjp-14679	93	49	-3.0	-3.0	PROPN
bjp-14679	93	50	kcal	kcal	PROPN
bjp-14679	93	51	/	/	SYM
bjp-14679	93	52	mol	mol	PROPN
bjp-14679	93	53	.	.	PUNCT
bjp-14679	94	1	the	the	DET
bjp-14679	94	2	other	other	ADJ
bjp-14679	94	3	7	7	NUM
bjp-14679	94	4	variants	variant	NOUN
bjp-14679	94	5	were	be	AUX
bjp-14679	94	6	showed	show	VERB
bjp-14679	94	7	a	a	DET
bjp-14679	94	8			ADV
bjp-14679	94	9	g	g	NOUN
bjp-14679	94	10	value	value	NOUN
bjp-14679	94	11	of	of	ADP
bjp-14679	94	12	-2.0	-2.0	PROPN
bjp-14679	94	13	kcal	kcal	PROPN
bjp-14679	94	14	/	/	SYM
bjp-14679	94	15	mol	mol	PROPN
bjp-14679	94	16	.	.	PUNCT
bjp-14679	95	1	the	the	DET
bjp-14679	95	2	other	other	ADJ
bjp-14679	95	3	16	16	NUM
bjp-14679	95	4	variants	variant	NOUN
bjp-14679	95	5	showed	show	VERB
bjp-14679	95	6	a	a	DET
bjp-14679	95	7			ADV
bjp-14679	95	8	g	g	NOUN
bjp-14679	95	9	value	value	NOUN
bjp-14679	95	10	of	of	ADP
bjp-14679	95	11	-1.0	-1.0	PROPN
bjp-14679	95	12	kcal	kcal	PROPN
bjp-14679	95	13	/	/	SYM
bjp-14679	95	14	mol	mol	PROPN
bjp-14679	95	15	.	.	PUNCT
bjp-14679	96	1	the	the	DET
bjp-14679	96	2	remaining	remain	VERB
bjp-14679	96	3	25	25	NUM
bjp-14679	96	4	variants	variant	NOUN
bjp-14679	96	5	showed	show	VERB
bjp-14679	96	6	a	a	DET
bjp-14679	96	7			ADV
bjp-14679	96	8	g	g	NOUN
bjp-14679	96	9	value	value	NOUN
bjp-14679	96	10	of	of	ADP
bjp-14679	96	11	<	<	X
bjp-14679	96	12	-1.0	-1.0	PROPN
bjp-14679	96	13	kcal	kcal	PROPN
bjp-14679	96	14	/	/	SYM
bjp-14679	96	15	mol	mol	PROPN
bjp-14679	96	16	as	as	SCONJ
bjp-14679	96	17	depicted	depict	VERB
bjp-14679	96	18	in	in	ADP
bjp-14679	96	19	table	table	NOUN
bjp-14679	96	20	i.	i.	NOUN
bjp-14679	96	21	out	out	ADP
bjp-14679	96	22	of	of	ADP
bjp-14679	96	23	53	53	NUM
bjp-14679	96	24	variants	variant	NOUN
bjp-14679	96	25	which	which	PRON
bjp-14679	96	26	showed	show	VERB
bjp-14679	96	27	a	a	DET
bjp-14679	96	28	negative	negative	ADJ
bjp-14679	96	29			ADV
bjp-14679	96	30	g	g	NOUN
bjp-14679	96	31	,	,	PUNCT
bjp-14679	96	32	4	4	NUM
bjp-14679	96	33	variants	variant	NOUN
bjp-14679	96	34	namely	namely	ADV
bjp-14679	96	35	,	,	PUNCT
bjp-14679	96	36	e864k	e864k	PROPN
bjp-14679	96	37	,	,	PUNCT
bjp-14679	96	38	e702k	e702k	NOUN
bjp-14679	96	39	,	,	PUNCT
bjp-14679	96	40	e880k	e880k	PROPN
bjp-14679	96	41	and	and	CCONJ
bjp-14679	96	42	e410k	e410k	PROPN
bjp-14679	96	43	changed	change	VERB
bjp-14679	96	44	their	their	PRON
bjp-14679	96	45	amino	amino	NOUN
bjp-14679	96	46	acid	acid	NOUN
bjp-14679	96	47	from	from	ADP
bjp-14679	96	48	negatively	negatively	ADV
bjp-14679	96	49	charged	charge	VERB
bjp-14679	96	50	to	to	PART
bjp-14679	96	51	positively	positively	ADV
bjp-14679	96	52	charged	charge	VERB
bjp-14679	96	53	amino	amino	NOUN
bjp-14679	96	54	acid	acid	NOUN
bjp-14679	96	55	;	;	PUNCT
bjp-14679	96	56	10	10	NUM
bjp-14679	96	57	variants	variant	NOUN
bjp-14679	96	58	such	such	ADJ
bjp-14679	96	59	as	as	ADP
bjp-14679	96	60	p597s	p597s	PROPN
bjp-14679	96	61	,	,	PUNCT
bjp-14679	96	62	g879s	g879s	PROPN
bjp-14679	96	63	,	,	PUNCT
bjp-14679	96	64	a709s	a709s	PROPN
bjp-14679	96	65	,	,	PUNCT
bjp-14679	96	66	m177	m177	PROPN
bjp-14679	96	67	t	t	PROPN
bjp-14679	96	68	,	,	PUNCT
bjp-14679	96	69	a80	a80	PROPN
bjp-14679	96	70	t	t	PROPN
bjp-14679	96	71	,	,	PUNCT
bjp-14679	96	72	a298	a298	PROPN
bjp-14679	96	73	t	t	PROPN
bjp-14679	96	74	,	,	PUNCT
bjp-14679	96	75	a617	a617	PROPN
bjp-14679	96	76	t	t	PROPN
bjp-14679	96	77	,	,	PUNCT
bjp-14679	96	78	p30	p30	PROPN
bjp-14679	96	79	t	t	PROPN
bjp-14679	96	80	,	,	PUNCT
bjp-14679	96	81	a592	a592	PROPN
bjp-14679	96	82	t	t	PROPN
bjp-14679	96	83	and	and	CCONJ
bjp-14679	96	84	i393n	i393n	PROPN
bjp-14679	96	85	changed	change	VERB
bjp-14679	96	86	from	from	ADP
bjp-14679	96	87	non	non	ADJ
bjp-14679	96	88	-	-	ADJ
bjp-14679	96	89	polar	polar	ADJ
bjp-14679	96	90	to	to	ADP
bjp-14679	96	91	polar	polar	ADJ
bjp-14679	96	92	amino	amino	NOUN
bjp-14679	96	93	acid	acid	NOUN
bjp-14679	96	94	;	;	PUNCT
bjp-14679	96	95	4	4	NUM
bjp-14679	96	96	variants	variant	NOUN
bjp-14679	96	97	,	,	PUNCT
bjp-14679	96	98	n666h	n666h	PROPN
bjp-14679	96	99	,	,	PUNCT
bjp-14679	96	100	c306r	c306r	PROPN
bjp-14679	96	101	,	,	PUNCT
bjp-14679	96	102	n751k	n751k	PROPN
bjp-14679	96	103	and	and	CCONJ
bjp-14679	96	104	c695r	c695r	PROPN
bjp-14679	96	105	changed	change	VERB
bjp-14679	96	106	from	from	ADP
bjp-14679	96	107	polar	polar	ADJ
bjp-14679	96	108	to	to	PART
bjp-14679	96	109	positively	positively	ADV
bjp-14679	96	110	charged	charge	VERB
bjp-14679	96	111	amino	amino	NOUN
bjp-14679	96	112	acid	acid	NOUN
bjp-14679	96	113	;	;	PUNCT
bjp-14679	96	114	5	5	NUM
bjp-14679	96	115	variants	variant	NOUN
bjp-14679	96	116	,	,	PUNCT
bjp-14679	96	117	t340	t340	PROPN
bjp-14679	96	118	m	m	NOUN
bjp-14679	96	119	,	,	PUNCT
bjp-14679	96	120	t340a	t340a	PROPN
bjp-14679	96	121	,	,	PUNCT
bjp-14679	96	122	t506a	t506a	PROPN
bjp-14679	96	123	,	,	PUNCT
bjp-14679	96	124	t211p	t211p	PROPN
bjp-14679	96	125	,	,	PUNCT
bjp-14679	96	126	t395a	t395a	PROPN
bjp-14679	96	127	and	and	CCONJ
bjp-14679	96	128	s838	s838	PRON
bjp-14679	96	129	g	g	NOUN
bjp-14679	96	130	changed	change	VERB
bjp-14679	96	131	from	from	ADP
bjp-14679	96	132	polar	polar	ADJ
bjp-14679	96	133	to	to	ADP
bjp-14679	96	134	non	non	ADJ
bjp-14679	96	135	-	-	ADJ
bjp-14679	96	136	polar	polar	ADJ
bjp-14679	96	137	amino	amino	NOUN
bjp-14679	96	138	acid	acid	NOUN
bjp-14679	96	139	.	.	PUNCT
bjp-14679	97	1	s543f	s543f	NOUN
bjp-14679	97	2	and	and	CCONJ
bjp-14679	97	3	n674y	n674y	PROPN
bjp-14679	97	4	changed	change	VERB
bjp-14679	97	5	from	from	ADP
bjp-14679	97	6	polar	polar	ADJ
bjp-14679	97	7	to	to	ADP
bjp-14679	97	8	aromatic	aromatic	ADJ
bjp-14679	97	9	amino	amino	NOUN
bjp-14679	97	10	acid	acid	NOUN
bjp-14679	97	11	.	.	PUNCT
bjp-14679	98	1	2	2	NUM
bjp-14679	98	2	variants	variant	NOUN
bjp-14679	98	3	,	,	PUNCT
bjp-14679	98	4	k184i	k184i	PROPN
bjp-14679	98	5	and	and	CCONJ
bjp-14679	98	6	k69	k69	PROPN
bjp-14679	98	7	t	t	PROPN
bjp-14679	98	8	changed	change	VERB
bjp-14679	98	9	from	from	ADP
bjp-14679	98	10	positively	positively	ADV
bjp-14679	98	11	charged	charge	VERB
bjp-14679	98	12	to	to	ADP
bjp-14679	98	13	bangladesh	bangladesh	PROPN
bjp-14679	98	14	j	j	PROPN
bjp-14679	98	15	pharmacol	pharmacol	PROPN
bjp-14679	98	16	2013	2013	NUM
bjp-14679	98	17	;	;	PUNCT
bjp-14679	98	18	8	8	NUM
bjp-14679	98	19	:	:	SYM
bjp-14679	98	20	207	207	NUM
bjp-14679	98	21	-	-	SYM
bjp-14679	98	22	213	213	NUM
bjp-14679	98	23	209	209	NUM
bjp-14679	98	24	210	210	NUM
bjp-14679	98	25	bangladesh	bangladesh	NOUN
bjp-14679	98	26	j	j	PROPN
bjp-14679	98	27	pharmacol	pharmacol	PROPN
bjp-14679	98	28	2013	2013	NUM
bjp-14679	98	29	;	;	PUNCT
bjp-14679	98	30	8	8	NUM
bjp-14679	98	31	:	:	SYM
bjp-14679	98	32	207	207	NUM
bjp-14679	98	33	-	-	SYM
bjp-14679	98	34	213	213	NUM
bjp-14679	98	35	table	table	NOUN
bjp-14679	98	36	i	i	PRON
bjp-14679	98	37	list	list	NOUN
bjp-14679	98	38	of	of	ADP
bjp-14679	98	39	variants	variant	NOUN
bjp-14679	98	40	that	that	PRON
bjp-14679	98	41	were	be	AUX
bjp-14679	98	42	predicted	predict	VERB
bjp-14679	98	43	to	to	PART
bjp-14679	98	44	be	be	AUX
bjp-14679	98	45	functionally	functionally	ADV
bjp-14679	98	46	significant	significant	ADJ
bjp-14679	98	47	by	by	ADP
bjp-14679	98	48	sift	sift	ADJ
bjp-14679	98	49	,	,	PUNCT
bjp-14679	98	50	polyphen	polyphen	ADV
bjp-14679	98	51	,	,	PUNCT
bjp-14679	98	52	i	i	PRON
bjp-14679	98	53	-	-	PUNCT
bjp-14679	98	54	mutant	mutant	VERB
bjp-14679	98	55	2.0	2.0	NUM
bjp-14679	98	56	amino	amino	NOUN
bjp-14679	98	57	acid	acid	NOUN
bjp-14679	98	58	change	change	NOUN
bjp-14679	98	59	tolerance	tolerance	NOUN
bjp-14679	98	60	index	index	NOUN
bjp-14679	98	61	psic	psic	ADJ
bjp-14679	98	62	sd	sd	PROPN
bjp-14679	98	63	prediction	prediction	NOUN
bjp-14679	99	1	ddg	ddg	PROPN
bjp-14679	99	2	(	(	PUNCT
bjp-14679	99	3	kcal	kcal	PROPN
bjp-14679	99	4	/	/	SYM
bjp-14679	99	5	mol	mol	NOUN
bjp-14679	99	6	)	)	PUNCT
bjp-14679	99	7	m203v	m203v	PROPN
bjp-14679	99	8	0.53	0.53	NUM
bjp-14679	99	9	0.002	0.002	NUM
bjp-14679	99	10	benign	benign	ADJ
bjp-14679	99	11	-0.52	-0.52	ADJ
bjp-14679	99	12	r29q	r29q	NOUN
bjp-14679	99	13	0.01	0.01	NUM
bjp-14679	99	14	0.697	0.697	NUM
bjp-14679	99	15	possibly	possibly	ADV
bjp-14679	99	16	damaging	damage	VERB
bjp-14679	99	17	-0.65	-0.65	ADP
bjp-14679	99	18	v153i	v153i	PROPN
bjp-14679	99	19	0.35	0.35	NUM
bjp-14679	99	20	0.012	0.012	NUM
bjp-14679	99	21	benign	benign	ADJ
bjp-14679	99	22	-0.5	-0.5	X
bjp-14679	99	23	t211p	t211p	PROPN
bjp-14679	99	24	0.03	0.03	NUM
bjp-14679	99	25	0.725	0.725	NUM
bjp-14679	99	26	possibly	possibly	ADV
bjp-14679	99	27	damaging	damage	VERB
bjp-14679	99	28	-3.18	-3.18	ADJ
bjp-14679	99	29	w483s	w483s	PROPN
bjp-14679	99	30	1	1	NUM
bjp-14679	99	31	0	0	NUM
bjp-14679	99	32	benign	benign	ADJ
bjp-14679	99	33	-0.86	-0.86	NOUN
bjp-14679	99	34	n155s	n155s	PROPN
bjp-14679	99	35	0.78	0.78	NUM
bjp-14679	99	36	0	0	NUM
bjp-14679	99	37	benign	benign	ADJ
bjp-14679	99	38	0.03	0.03	NUM
bjp-14679	99	39	r162w	r162w	PROPN
bjp-14679	99	40	0.01	0.01	NUM
bjp-14679	99	41	0.997	0.997	NUM
bjp-14679	99	42	probably	probably	ADV
bjp-14679	99	43	damaging	damage	VERB
bjp-14679	99	44	0.03	0.03	NUM
bjp-14679	99	45	r28w	r28w	NOUN
bjp-14679	99	46	0	0	NUM
bjp-14679	99	47	0	0	NUM
bjp-14679	99	48	benign	benign	NOUN
bjp-14679	99	49	-2.28	-2.28	NOUN
bjp-14679	99	50	v138	v138	PROPN
bjp-14679	99	51	m	m	PROPN
bjp-14679	99	52	0.18	0.18	NUM
bjp-14679	99	53	0.156	0.156	NUM
bjp-14679	99	54	benign	benign	ADJ
bjp-14679	99	55	0.82	0.82	NUM
bjp-14679	99	56	a80	a80	NOUN
bjp-14679	99	57	t	t	PROPN
bjp-14679	99	58	0.06	0.06	NUM
bjp-14679	99	59	0.005	0.005	NUM
bjp-14679	99	60	nil	nil	NOUN
bjp-14679	99	61	-1.19	-1.19	NOUN
bjp-14679	99	62	r169h	r169h	NOUN
bjp-14679	99	63	0	0	NUM
bjp-14679	99	64	0.984	0.984	NUM
bjp-14679	99	65	probably	probably	ADV
bjp-14679	99	66	damaging	damage	VERB
bjp-14679	99	67	-2.35	-2.35	NOUN
bjp-14679	99	68	m177	m177	PROPN
bjp-14679	99	69	t	t	NOUN
bjp-14679	99	70	0.61	0.61	NUM
bjp-14679	99	71	0	0	NUM
bjp-14679	99	72	benign	benign	ADJ
bjp-14679	99	73	-3.15	-3.15	NOUN
bjp-14679	99	74	k69	k69	NOUN
bjp-14679	99	75	t	t	PROPN
bjp-14679	99	76	0.25	0.25	NUM
bjp-14679	99	77	0.939	0.939	NUM
bjp-14679	99	78	possibly	possibly	ADV
bjp-14679	99	79	damaging	damage	VERB
bjp-14679	99	80	-1.2	-1.2	NOUN
bjp-14679	99	81	c306r	c306r	NOUN
bjp-14679	99	82	0.01	0.01	NUM
bjp-14679	99	83	0.004	0.004	NUM
bjp-14679	99	84	benign	benign	NOUN
bjp-14679	99	85	0.22	0.22	NUM
bjp-14679	99	86	e336d	e336d	PROPN
bjp-14679	99	87	0.04	0.04	NUM
bjp-14679	99	88	0.963	0.963	NUM
bjp-14679	99	89	probably	probably	ADV
bjp-14679	99	90	damaging	damage	VERB
bjp-14679	99	91	-1.07	-1.07	ADJ
bjp-14679	99	92	n674y	n674y	PROPN
bjp-14679	99	93	0.01	0.01	NUM
bjp-14679	99	94	0.99	0.99	NUM
bjp-14679	99	95	probably	probably	ADV
bjp-14679	99	96	damaging	damage	VERB
bjp-14679	99	97	1.22	1.22	NUM
bjp-14679	99	98	p597s	p597s	VERB
bjp-14679	99	99	0.69	0.69	NUM
bjp-14679	99	100	0.326	0.326	NUM
bjp-14679	99	101	benign	benign	ADJ
bjp-14679	99	102	-0.62	-0.62	NOUN
bjp-14679	99	103	r224h	r224h	NOUN
bjp-14679	99	104	0.17	0.17	NUM
bjp-14679	99	105	0	0	NUM
bjp-14679	99	106	benign	benign	ADJ
bjp-14679	99	107	-2.72	-2.72	NOUN
bjp-14679	99	108	k182n	k182n	PROPN
bjp-14679	99	109	0.28	0.28	NUM
bjp-14679	99	110	0.103	0.103	NUM
bjp-14679	99	111	benign	benign	ADJ
bjp-14679	99	112	-1.68	-1.68	NOUN
bjp-14679	99	113	t395a	t395a	PROPN
bjp-14679	99	114	0.52	0.52	NUM
bjp-14679	99	115	0.008	0.008	NUM
bjp-14679	99	116	benign	benign	NOUN
bjp-14679	99	117	-0.47	-0.47	PRON
bjp-14679	99	118	m282i	m282i	PROPN
bjp-14679	99	119	0.14	0.14	NUM
bjp-14679	99	120	0.997	0.997	NUM
bjp-14679	99	121	probably	probably	ADV
bjp-14679	99	122	damaging	damage	VERB
bjp-14679	99	123	0.57	0.57	NUM
bjp-14679	99	124	g879s	g879	VERB
bjp-14679	99	125	0.02	0.02	NUM
bjp-14679	99	126	1	1	NUM
bjp-14679	99	127	probably	probably	ADV
bjp-14679	99	128	damaging	damage	VERB
bjp-14679	99	129	-2.1	-2.1	NOUN
bjp-14679	99	130	d805n	d805n	PROPN
bjp-14679	99	131	0.09	0.09	NUM
bjp-14679	99	132	1	1	NUM
bjp-14679	99	133	probably	probably	ADV
bjp-14679	99	134	damaging	damage	VERB
bjp-14679	99	135	-0.34	-0.34	ADJ
bjp-14679	99	136	k184i	k184i	PROPN
bjp-14679	99	137	0.14	0.14	NUM
bjp-14679	99	138	0.984	0.984	NUM
bjp-14679	99	139	probably	probably	ADV
bjp-14679	99	140	damaging	damage	VERB
bjp-14679	99	141	-0.65	-0.65	ADP
bjp-14679	99	142	r224c	r224c	PROPN
bjp-14679	99	143	0.04	0.04	NUM
bjp-14679	99	144	0.657	0.657	NUM
bjp-14679	99	145	possibly	possibly	ADV
bjp-14679	99	146	damaging	damage	VERB
bjp-14679	99	147	-2.42	-2.42	ADJ
bjp-14679	99	148	d882n	d882n	NOUN
bjp-14679	99	149	0	0	NUM
bjp-14679	99	150	1	1	NUM
bjp-14679	99	151	probably	probably	ADV
bjp-14679	99	152	damaging	damage	VERB
bjp-14679	99	153	-1.29	-1.29	PROPN
bjp-14679	99	154	d433n	d433n	PROPN
bjp-14679	99	155	0.45	0.45	NUM
bjp-14679	99	156	0.023	0.023	NUM
bjp-14679	99	157	benign	benign	ADJ
bjp-14679	99	158	-3.47	-3.47	NOUN
bjp-14679	99	159	e410k	e410k	NOUN
bjp-14679	99	160	0.94	0.94	NUM
bjp-14679	99	161	0	0	NUM
bjp-14679	99	162	benign	benign	ADJ
bjp-14679	99	163	-2.3	-2.3	NOUN
bjp-14679	99	164	y755c	y755c	PROPN
bjp-14679	99	165	0	0	NUM
bjp-14679	99	166	1	1	NUM
bjp-14679	99	167	probably	probably	ADV
bjp-14679	99	168	damaging	damage	VERB
bjp-14679	99	169	-1.04	-1.04	NOUN
bjp-14679	99	170	a401d	a401d	PROPN
bjp-14679	99	171	0.63	0.63	NUM
bjp-14679	99	172	0.003	0.003	NUM
bjp-14679	99	173	benign	benign	NOUN
bjp-14679	99	174	-0.52	-0.52	ADJ
bjp-14679	99	175	n666h	n666h	PROPN
bjp-14679	99	176	0.63	0.63	NUM
bjp-14679	99	177	0.004	0.004	NUM
bjp-14679	99	178	benign	benign	ADJ
bjp-14679	99	179	-0.38	-0.38	PUNCT
bjp-14679	99	180	e702k	e702k	NOUN
bjp-14679	99	181	0.56	0.56	NUM
bjp-14679	99	182	0.014	0.014	NUM
bjp-14679	99	183	benign	benign	NOUN
bjp-14679	99	184	-0.65	-0.65	ADP
bjp-14679	99	185	s543f	s543f	NOUN
bjp-14679	99	186	0.08	0.08	NUM
bjp-14679	99	187	0.011	0.011	NUM
bjp-14679	99	188	benign	benign	ADJ
bjp-14679	99	189	0.16	0.16	NUM
bjp-14679	99	190	n622s	n622s	NOUN
bjp-14679	99	191	0.01	0.01	NUM
bjp-14679	99	192	0.901	0.901	NUM
bjp-14679	99	193	possibly	possibly	ADV
bjp-14679	99	194	damaging	damage	VERB
bjp-14679	99	195	-0.55	-0.55	NUM
bjp-14679	99	196	p201r	p201r	PROPN
bjp-14679	99	197	0	0	NUM
bjp-14679	99	198	1	1	NUM
bjp-14679	99	199	probably	probably	ADV
bjp-14679	99	200	damaging	damage	VERB
bjp-14679	99	201	-0.05	-0.05	ADJ
bjp-14679	99	202	i535v	i535v	ADJ
bjp-14679	99	203	0.22	0.22	NUM
bjp-14679	99	204	0.001	0.001	NUM
bjp-14679	99	205	benign	benign	ADJ
bjp-14679	99	206	-0.69	-0.69	NOUN
bjp-14679	99	207	k381n	k381n	PROPN
bjp-14679	99	208	0.39	0.39	NUM
bjp-14679	99	209	0.001	0.001	NUM
bjp-14679	99	210	benign	benign	ADJ
bjp-14679	99	211	-1.82	-1.82	ADJ
bjp-14679	99	212	e864k	e864k	PROPN
bjp-14679	99	213	0.28	0.28	NUM
bjp-14679	99	214	0.867	0.867	NUM
bjp-14679	99	215	possibly	possibly	ADV
bjp-14679	99	216	damaging	damage	VERB
bjp-14679	99	217	-0.6	-0.6	NOUN
bjp-14679	99	218	a298	a298	PROPN
bjp-14679	99	219	t	t	PROPN
bjp-14679	99	220	0.02	0.02	NUM
bjp-14679	99	221	0.999	0.999	NUM
bjp-14679	99	222	probably	probably	ADV
bjp-14679	99	223	damaging	damage	VERB
bjp-14679	99	224	-2.39	-2.39	NOUN
bjp-14679	99	225	v132i	v132i	CCONJ
bjp-14679	99	226	0.25	0.25	NUM
bjp-14679	99	227	0.322	0.322	NUM
bjp-14679	99	228	benign	benign	ADJ
bjp-14679	99	229	0.95	0.95	NUM
bjp-14679	99	230	v392i	v392i	PROPN
bjp-14679	99	231	0.33	0.33	NUM
bjp-14679	99	232	0.001	0.001	NUM
bjp-14679	99	233	benign	benign	ADJ
bjp-14679	99	234	1	1	NUM
bjp-14679	99	235	d768n	d768n	PROPN
bjp-14679	99	236	0	0	NUM
bjp-14679	99	237	1	1	NUM
bjp-14679	99	238	probably	probably	ADV
bjp-14679	99	239	damaging	damage	VERB
bjp-14679	99	240	-0.18	-0.18	NUM
bjp-14679	99	241	p30	p30	NOUN
bjp-14679	99	242	t	t	PROPN
bjp-14679	99	243	0.12	0.12	NUM
bjp-14679	99	244	0.986	0.986	NUM
bjp-14679	99	245	probably	probably	ADV
bjp-14679	99	246	damaging	damage	VERB
bjp-14679	99	247	-0.56	-0.56	ADJ
bjp-14679	99	248	a788v	a788v	PROPN
bjp-14679	99	249	0.23	0.23	NUM
bjp-14679	99	250	0.722	0.722	NUM
bjp-14679	99	251	possibly	possibly	ADV
bjp-14679	99	252	damaging	damage	VERB
bjp-14679	99	253	-1.47	-1.47	ADJ
bjp-14679	99	254	a408v	a408v	PROPN
bjp-14679	99	255	0.3	0.3	NUM
bjp-14679	99	256	0.995	0.995	NUM
bjp-14679	99	257	probably	probably	ADV
bjp-14679	99	258	damaging	damage	VERB
bjp-14679	99	259	-0.77	-0.77	NUM
bjp-14679	99	260	a709s	a709s	PROPN
bjp-14679	99	261	0.31	0.31	NUM
bjp-14679	99	262	0.995	0.995	NUM
bjp-14679	99	263	probably	probably	ADV
bjp-14679	99	264	damaging	damage	VERB
bjp-14679	99	265	-0.27	-0.27	NOUN
bjp-14679	99	266	a634v	a634v	PROPN
bjp-14679	99	267	0.52	0.52	NUM
bjp-14679	99	268	0.051	0.051	NUM
bjp-14679	99	269	benign	benign	ADJ
bjp-14679	99	270	-0.19	-0.19	NOUN
bjp-14679	99	271	s838	s838	PROPN
bjp-14679	99	272	g	g	NOUN
bjp-14679	99	273	0.67	0.67	NUM
bjp-14679	99	274	0.022	0.022	NUM
bjp-14679	99	275	benign	benign	ADJ
bjp-14679	99	276	-1.7	-1.7	PROPN
bjp-14679	99	277	l711v	l711v	PROPN
bjp-14679	99	278	0.02	0.02	NUM
bjp-14679	99	279	0.864	0.864	NUM
bjp-14679	99	280	possibly	possibly	ADV
bjp-14679	99	281	damaging	damage	VERB
bjp-14679	99	282	-0.05	-0.05	NOUN
bjp-14679	99	283	t340a	t340a	PROPN
bjp-14679	99	284	0.62	0.62	NUM
bjp-14679	99	285	0.001	0.001	NUM
bjp-14679	99	286	benign	benign	ADJ
bjp-14679	99	287	-3.58	-3.58	NOUN
bjp-14679	99	288	v574f	v574f	NOUN
bjp-14679	99	289	0.02	0.02	NUM
bjp-14679	99	290	0.067	0.067	NUM
bjp-14679	99	291	benign	benign	ADJ
bjp-14679	99	292	-0.55	-0.55	NOUN
bjp-14679	99	293	r124h	r124h	PROPN
bjp-14679	99	294	0.14	0.14	NUM
bjp-14679	99	295	0	0	NUM
bjp-14679	99	296	benign	benign	ADJ
bjp-14679	99	297	-2.47	-2.47	X
bjp-14679	99	298	d676n	d676n	PROPN
bjp-14679	99	299	0.25	0.25	NUM
bjp-14679	99	300	0.752	0.752	NUM
bjp-14679	99	301	possibly	possibly	ADV
bjp-14679	99	302	damaging	damage	VERB
bjp-14679	99	303	-1.98	-1.98	PRON
bjp-14679	99	304	t506a	t506a	PROPN
bjp-14679	99	305	1	1	NUM
bjp-14679	99	306	0	0	NUM
bjp-14679	99	307	benign	benign	ADJ
bjp-14679	99	308	0.28	0.28	NUM
bjp-14679	99	309	v242i	v242i	NOUN
bjp-14679	99	310	0.35	0.35	NUM
bjp-14679	99	311	0.006	0.006	NUM
bjp-14679	99	312	benign	benign	ADJ
bjp-14679	99	313	-0.45	-0.45	NOUN
bjp-14679	99	314	t340	t340	NUM
bjp-14679	99	315	m	m	NOUN
bjp-14679	99	316	0.12	0.12	NUM
bjp-14679	99	317	0.085	0.085	NUM
bjp-14679	99	318	benign	benign	ADJ
bjp-14679	99	319	-1.09	-1.09	X
bjp-14679	99	320	d498e	d498e	NOUN
bjp-14679	99	321	0.04	0.04	NUM
bjp-14679	99	322	0.903	0.903	NUM
bjp-14679	99	323	possibly	possibly	ADV
bjp-14679	99	324	damaging	damage	VERB
bjp-14679	99	325	-0.16	-0.16	DET
bjp-14679	99	326	non	non	ADJ
bjp-14679	99	327	-	-	ADJ
bjp-14679	99	328	polar	polar	ADJ
bjp-14679	99	329	amino	amino	NOUN
bjp-14679	99	330	acid	acid	NOUN
bjp-14679	99	331	;	;	PUNCT
bjp-14679	99	332	r29q	r29q	NOUN
bjp-14679	99	333	,	,	PUNCT
bjp-14679	99	334	r224h	r224h	NOUN
bjp-14679	99	335	,	,	PUNCT
bjp-14679	99	336	k182n	k182n	PROPN
bjp-14679	99	337	,	,	PUNCT
bjp-14679	99	338	r224c	r224c	PROPN
bjp-14679	99	339	and	and	CCONJ
bjp-14679	99	340	k381n	k381n	PROPN
bjp-14679	99	341	changed	change	VERB
bjp-14679	99	342	from	from	ADP
bjp-14679	99	343	positively	positively	ADV
bjp-14679	99	344	charged	charge	VERB
bjp-14679	99	345	to	to	ADP
bjp-14679	99	346	polar	polar	ADJ
bjp-14679	99	347	amino	amino	NOUN
bjp-14679	99	348	acid	acid	NOUN
bjp-14679	99	349	;	;	PUNCT
bjp-14679	99	350	r162w	r162w	ADJ
bjp-14679	99	351	and	and	CCONJ
bjp-14679	99	352	r28w	r28w	NOUN
bjp-14679	99	353	changed	change	VERB
bjp-14679	99	354	from	from	ADP
bjp-14679	99	355	positively	positively	ADV
bjp-14679	99	356	charged	charge	VERB
bjp-14679	99	357	to	to	ADP
bjp-14679	99	358	aromatic	aromatic	ADJ
bjp-14679	99	359	amino	amino	NOUN
bjp-14679	99	360	acid	acid	NOUN
bjp-14679	99	361	.	.	PUNCT
bjp-14679	100	1	6	6	NUM
bjp-14679	100	2	variants	variant	NOUN
bjp-14679	100	3	,	,	PUNCT
bjp-14679	100	4	d805n	d805n	PROPN
bjp-14679	100	5	,	,	PUNCT
bjp-14679	100	6	d882n	d882n	PROPN
bjp-14679	100	7	,	,	PUNCT
bjp-14679	100	8	d443n	d443n	PROPN
bjp-14679	100	9	,	,	PUNCT
bjp-14679	100	10	d768n	d768n	PROPN
bjp-14679	100	11	,	,	PUNCT
bjp-14679	100	12	d676n	d676n	PROPN
bjp-14679	100	13	and	and	CCONJ
bjp-14679	100	14	d72n	d72n	PROPN
bjp-14679	100	15	changed	change	VERB
bjp-14679	100	16	from	from	ADP
bjp-14679	100	17	negatively	negatively	ADV
bjp-14679	100	18	charged	charge	VERB
bjp-14679	100	19	to	to	ADP
bjp-14679	100	20	polar	polar	ADJ
bjp-14679	100	21	amino	amino	NOUN
bjp-14679	100	22	acid	acid	NOUN
bjp-14679	100	23	;	;	PUNCT
bjp-14679	100	24	w483s	w483s	PROPN
bjp-14679	100	25	and	and	CCONJ
bjp-14679	100	26	y755c	y755c	PROPN
bjp-14679	100	27	changed	change	VERB
bjp-14679	100	28	from	from	ADP
bjp-14679	100	29	aromatic	aromatic	ADJ
bjp-14679	100	30	to	to	ADP
bjp-14679	100	31	polar	polar	ADJ
bjp-14679	100	32	amino	amino	NOUN
bjp-14679	100	33	acid	acid	NOUN
bjp-14679	100	34	.	.	PUNCT
bjp-14679	101	1	finally	finally	ADV
bjp-14679	101	2	,	,	PUNCT
bjp-14679	101	3	the	the	DET
bjp-14679	101	4	variants	variant	NOUN
bjp-14679	101	5	such	such	ADJ
bjp-14679	101	6	as	as	ADP
bjp-14679	101	7	a401d	a401d	PROPN
bjp-14679	101	8	,	,	PUNCT
bjp-14679	101	9	p201r	p201r	PROPN
bjp-14679	101	10	and	and	CCONJ
bjp-14679	101	11	v574f	v574f	PROPN
bjp-14679	101	12	changed	change	VERB
bjp-14679	101	13	from	from	ADP
bjp-14679	101	14	non	non	ADJ
bjp-14679	101	15	-	-	ADJ
bjp-14679	101	16	polar	polar	ADJ
bjp-14679	101	17	to	to	PART
bjp-14679	101	18	negatively	negatively	ADV
bjp-14679	101	19	charged	charge	VERB
bjp-14679	101	20	,	,	PUNCT
bjp-14679	101	21	positively	positively	ADV
bjp-14679	101	22	charged	charge	VERB
bjp-14679	101	23	and	and	CCONJ
bjp-14679	101	24	aromatic	aromatic	ADJ
bjp-14679	101	25	amino	amino	NOUN
bjp-14679	101	26	acid	acid	NOUN
bjp-14679	101	27	,	,	PUNCT
bjp-14679	101	28	respectively	respectively	ADV
bjp-14679	101	29	.	.	PUNCT
bjp-14679	102	1	it	it	PRON
bjp-14679	102	2	is	be	AUX
bjp-14679	102	3	also	also	ADV
bjp-14679	102	4	to	to	PART
bjp-14679	102	5	be	be	AUX
bjp-14679	102	6	noted	note	VERB
bjp-14679	102	7	that	that	SCONJ
bjp-14679	102	8	m203v	m203v	PROPN
bjp-14679	102	9	,	,	PUNCT
bjp-14679	102	10	m282i	m282i	PROPN
bjp-14679	102	11	,	,	PUNCT
bjp-14679	102	12	a408v	a408v	PROPN
bjp-14679	102	13	,	,	PUNCT
bjp-14679	102	14	a634v	a634v	PROPN
bjp-14679	102	15	,	,	PUNCT
bjp-14679	102	16	a788v	a788v	PROPN
bjp-14679	102	17	,	,	PUNCT
bjp-14679	102	18	v242i	v242i	PROPN
bjp-14679	102	19	,	,	PUNCT
bjp-14679	102	20	v153i	v153i	PROPN
bjp-14679	102	21	,	,	PUNCT
bjp-14679	102	22	v392i	v392i	PROPN
bjp-14679	102	23	,	,	PUNCT
bjp-14679	102	24	v132i	v132i	PROPN
bjp-14679	102	25	,	,	PUNCT
bjp-14679	102	26	v473i	v473i	PROPN
bjp-14679	102	27	,	,	PUNCT
bjp-14679	102	28	l711v	l711v	PROPN
bjp-14679	102	29	,	,	PUNCT
bjp-14679	102	30	l630v	l630v	PROPN
bjp-14679	102	31	,	,	PUNCT
bjp-14679	102	32	l478p	l478p	PROPN
bjp-14679	102	33	,	,	PUNCT
bjp-14679	102	34	i535v	i535v	PROPN
bjp-14679	102	35	,	,	PUNCT
bjp-14679	102	36	v138	v138	PROPN
bjp-14679	102	37	m	m	PROPN
bjp-14679	102	38	and	and	CCONJ
bjp-14679	102	39	v832	v832	PROPN
bjp-14679	102	40	m	m	PROPN
bjp-14679	102	41	variants	variant	NOUN
bjp-14679	102	42	retained	retain	VERB
bjp-14679	102	43	non	non	ADJ
bjp-14679	102	44	-	-	ADJ
bjp-14679	102	45	polar	polar	ADJ
bjp-14679	102	46	amino	amino	NOUN
bjp-14679	102	47	acid	acid	NOUN
bjp-14679	102	48	,	,	PUNCT
bjp-14679	102	49	n155s	n155s	PROPN
bjp-14679	102	50	and	and	CCONJ
bjp-14679	102	51	n622s	n622s	PROPN
bjp-14679	102	52	variants	variant	NOUN
bjp-14679	102	53	retains	retain	VERB
bjp-14679	102	54	polar	polar	ADJ
bjp-14679	102	55	amino	amino	NOUN
bjp-14679	102	56	acid	acid	NOUN
bjp-14679	102	57	,	,	PUNCT
bjp-14679	102	58	e336d	e336d	PROPN
bjp-14679	102	59	and	and	CCONJ
bjp-14679	102	60	d498e	d498e	PROPN
bjp-14679	102	61	,	,	PUNCT
bjp-14679	102	62	variants	variant	NOUN
bjp-14679	102	63	retained	retain	VERB
bjp-14679	102	64	negatively	negatively	ADV
bjp-14679	102	65	charged	charge	VERB
bjp-14679	102	66	amino	amino	NOUN
bjp-14679	102	67	acid	acid	NOUN
bjp-14679	102	68	,	,	PUNCT
bjp-14679	102	69	r169h	r169h	PROPN
bjp-14679	102	70	and	and	CCONJ
bjp-14679	102	71	r124h	r124h	PROPN
bjp-14679	102	72	,	,	PUNCT
bjp-14679	102	73	variants	variant	NOUN
bjp-14679	102	74	retained	retain	VERB
bjp-14679	102	75	positively	positively	ADV
bjp-14679	102	76	charged	charge	VERB
bjp-14679	102	77	amino	amino	NOUN
bjp-14679	102	78	acid	acid	NOUN
bjp-14679	102	79	property	property	NOUN
bjp-14679	102	80	were	be	AUX
bjp-14679	102	81	found	find	VERB
bjp-14679	102	82	to	to	PART
bjp-14679	102	83	be	be	AUX
bjp-14679	102	84	less	less	ADV
bjp-14679	102	85	stable	stable	ADJ
bjp-14679	102	86	by	by	ADP
bjp-14679	102	87	i	i	NOUN
bjp-14679	102	88	-	-	PUNCT
bjp-14679	102	89	mutant	mutant	NOUN
bjp-14679	102	90	2.0	2.0	NUM
bjp-14679	102	91	.	.	PUNCT
bjp-14679	103	1	most	most	ADV
bjp-14679	103	2	importantly	importantly	ADV
bjp-14679	103	3	,	,	PUNCT
bjp-14679	103	4	18	18	NUM
bjp-14679	103	5	variants	variant	NOUN
bjp-14679	103	6	were	be	AUX
bjp-14679	103	7	considered	consider	VERB
bjp-14679	103	8	to	to	PART
bjp-14679	103	9	be	be	AUX
bjp-14679	103	10	damaging	damage	VERB
bjp-14679	103	11	by	by	ADP
bjp-14679	103	12	polyphen	polyphen	ADJ
bjp-14679	103	13	program	program	NOUN
bjp-14679	103	14	were	be	AUX
bjp-14679	103	15	also	also	ADV
bjp-14679	103	16	seen	see	VERB
bjp-14679	103	17	to	to	PART
bjp-14679	103	18	be	be	AUX
bjp-14679	103	19	deleterious	deleterious	ADJ
bjp-14679	103	20	according	accord	VERB
bjp-14679	103	21	to	to	ADP
bjp-14679	103	22	i	i	PROPN
bjp-14679	103	23	-	-	PUNCT
bjp-14679	103	24	mutant2.0	mutant2.0	PROPN
bjp-14679	103	25	program	program	NOUN
bjp-14679	103	26	.	.	PUNCT
bjp-14679	104	1	the	the	DET
bjp-14679	104	2	above	above	ADJ
bjp-14679	104	3	point	point	NOUN
bjp-14679	104	4	portrays	portray	VERB
bjp-14679	104	5	that	that	SCONJ
bjp-14679	104	6	preserving	preserve	VERB
bjp-14679	104	7	amino	amino	NOUN
bjp-14679	104	8	acid	acid	NOUN
bjp-14679	104	9	physico	physico	NOUN
bjp-14679	104	10	-	-	PUNCT
bjp-14679	104	11	chemical	chemical	NOUN
bjp-14679	104	12	properties	property	NOUN
bjp-14679	104	13	does	do	AUX
bjp-14679	104	14	not	not	PART
bjp-14679	104	15	necessary	necessary	ADJ
bjp-14679	104	16	result	result	NOUN
bjp-14679	104	17	in	in	ADP
bjp-14679	104	18	harmless	harmless	ADJ
bjp-14679	104	19	mutation	mutation	NOUN
bjp-14679	104	20	.	.	PUNCT
bjp-14679	105	1	indeed	indeed	ADV
bjp-14679	105	2	considering	consider	VERB
bjp-14679	105	3	only	only	ADJ
bjp-14679	105	4	amino	amino	NOUN
bjp-14679	105	5	acid	acid	NOUN
bjp-14679	105	6	substitution	substitution	NOUN
bjp-14679	105	7	based	base	VERB
bjp-14679	105	8	on	on	ADP
bjp-14679	105	9	physico	physico	NOUN
bjp-14679	105	10	-	-	PUNCT
bjp-14679	105	11	chemical	chemical	NOUN
bjp-14679	105	12	properties	property	NOUN
bjp-14679	105	13	could	could	AUX
bjp-14679	105	14	not	not	PART
bjp-14679	105	15	be	be	AUX
bjp-14679	105	16	able	able	ADJ
bjp-14679	105	17	to	to	PART
bjp-14679	105	18	identify	identify	VERB
bjp-14679	105	19	the	the	DET
bjp-14679	105	20	detrimental	detrimental	ADJ
bjp-14679	105	21	effect	effect	NOUN
bjp-14679	105	22	rather	rather	ADV
bjp-14679	105	23	than	than	ADP
bjp-14679	105	24	considering	consider	VERB
bjp-14679	105	25	the	the	DET
bjp-14679	105	26	sequence	sequence	NOUN
bjp-14679	105	27	conservation	conservation	NOUN
bjp-14679	105	28	along	along	ADP
bjp-14679	105	29	with	with	ADP
bjp-14679	105	30	the	the	DET
bjp-14679	105	31	above	above	NOUN
bjp-14679	105	32	said	say	VERB
bjp-14679	105	33	properties	property	NOUN
bjp-14679	105	34	could	could	AUX
bjp-14679	105	35	have	have	VERB
bjp-14679	105	36	more	more	ADJ
bjp-14679	105	37	bangladesh	bangladesh	NOUN
bjp-14679	105	38	j	j	PROPN
bjp-14679	105	39	pharmacol	pharmacol	PROPN
bjp-14679	105	40	2013	2013	NUM
bjp-14679	105	41	;	;	PUNCT
bjp-14679	105	42	8	8	NUM
bjp-14679	105	43	:	:	PUNCT
bjp-14679	105	44	207	207	NUM
bjp-14679	105	45	-	-	SYM
bjp-14679	105	46	213	213	NUM
bjp-14679	105	47	211	211	NUM
bjp-14679	105	48	table	table	NOUN
bjp-14679	105	49	ii	ii	NOUN
bjp-14679	105	50	disease	disease	NOUN
bjp-14679	105	51	related	relate	VERB
bjp-14679	105	52	prediction	prediction	NOUN
bjp-14679	105	53	by	by	ADP
bjp-14679	105	54	snps	snps	PROPN
bjp-14679	105	55	&	&	CCONJ
bjp-14679	105	56	go	go	VERB
bjp-14679	105	57	variants	variant	NOUN
bjp-14679	105	58	ri	ri	NOUN
bjp-14679	105	59	prediction	prediction	NOUN
bjp-14679	105	60	e336d	e336d	PROPN
bjp-14679	105	61	6	6	NUM
bjp-14679	105	62	disease	disease	NOUN
bjp-14679	105	63	a298	a298	PROPN
bjp-14679	105	64	t	t	PROPN
bjp-14679	105	65	7	7	NUM
bjp-14679	105	66	disease	disease	NOUN
bjp-14679	105	67	p201r	p201r	PROPN
bjp-14679	105	68	6	6	NUM
bjp-14679	105	69	disease	disease	NOUN
bjp-14679	105	70	c695r	c695r	ADP
bjp-14679	105	71	1	1	NUM
bjp-14679	105	72	neutral	neutral	ADJ
bjp-14679	105	73	g879s	g879	VERB
bjp-14679	105	74	1	1	NUM
bjp-14679	105	75	neutral	neutral	ADJ
bjp-14679	105	76	d882n	d882n	NOUN
bjp-14679	105	77	4	4	NUM
bjp-14679	106	1	neutral	neutral	ADJ
bjp-14679	106	2	y755c	y755c	PROPN
bjp-14679	106	3	1	1	NUM
bjp-14679	106	4	disease	disease	NOUN
bjp-14679	106	5	r169h	r169h	PROPN
bjp-14679	106	6	6	6	NUM
bjp-14679	106	7	disease	disease	NOUN
bjp-14679	106	8	d768n	d768n	PROPN
bjp-14679	106	9	1	1	NUM
bjp-14679	106	10	neutral	neutral	ADJ
bjp-14679	106	11	n751k	n751k	PROPN
bjp-14679	106	12	1	1	NUM
bjp-14679	106	13	neutral	neutral	PROPN
bjp-14679	106	14	ri<5	ri<5	PROPN
bjp-14679	106	15	predicted	predict	VERB
bjp-14679	106	16	to	to	PART
bjp-14679	106	17	be	be	AUX
bjp-14679	106	18	neutral	neutral	ADJ
bjp-14679	106	19	and	and	CCONJ
bjp-14679	106	20	ri>5	ri>5	ADV
bjp-14679	106	21	predicted	predict	VERB
bjp-14679	106	22	to	to	PART
bjp-14679	106	23	be	be	AUX
bjp-14679	106	24	disease	disease	NOUN
bjp-14679	106	25	a	a	DET
bjp-14679	106	26	b	b	NOUN
bjp-14679	106	27	c	c	NOUN
bjp-14679	106	28	d	d	X
bjp-14679	106	29	e	e	X
bjp-14679	106	30	figure	figure	NOUN
bjp-14679	106	31	1	1	NUM
bjp-14679	106	32	:	:	PUNCT
bjp-14679	106	33	pymol	pymol	NOUN
bjp-14679	106	34	view	view	NOUN
bjp-14679	106	35	of	of	ADP
bjp-14679	106	36	modelled	model	VERB
bjp-14679	106	37	structures	structure	NOUN
bjp-14679	106	38	(	(	PUNCT
bjp-14679	106	39	a	a	X
bjp-14679	106	40	)	)	PUNCT
bjp-14679	106	41	native	native	ADJ
bjp-14679	106	42	structure	structure	NOUN
bjp-14679	106	43	(	(	PUNCT
bjp-14679	106	44	b	b	NOUN
bjp-14679	106	45	)	)	PUNCT
bjp-14679	106	46	mutant	mutant	NOUN
bjp-14679	106	47	(	(	PUNCT
bjp-14679	106	48	e336d	e336d	PROPN
bjp-14679	106	49	)	)	PUNCT
bjp-14679	106	50	structure	structure	NOUN
bjp-14679	106	51	(	(	PUNCT
bjp-14679	106	52	c	c	NOUN
bjp-14679	106	53	)	)	PUNCT
bjp-14679	106	54	mutant	mutant	NOUN
bjp-14679	106	55	(	(	PUNCT
bjp-14679	106	56	a298	a298	PROPN
bjp-14679	106	57	t	t	NOUN
bjp-14679	106	58	)	)	PUNCT
bjp-14679	106	59	structure	structure	NOUN
bjp-14679	106	60	(	(	PUNCT
bjp-14679	106	61	d	d	NOUN
bjp-14679	106	62	)	)	PUNCT
bjp-14679	106	63	mutant	mutant	NOUN
bjp-14679	106	64	(	(	PUNCT
bjp-14679	106	65	p201r	p201r	PROPN
bjp-14679	106	66	)	)	PUNCT
bjp-14679	106	67	structure	structure	NOUN
bjp-14679	106	68	(	(	PUNCT
bjp-14679	106	69	e	e	NOUN
bjp-14679	106	70	)	)	PUNCT
bjp-14679	106	71	mutant	mutant	NOUN
bjp-14679	106	72	(	(	PUNCT
bjp-14679	106	73	r169h	r169h	PROPN
bjp-14679	106	74	)	)	PUNCT
bjp-14679	106	75	structure	structure	NOUN
bjp-14679	106	76	table	table	NOUN
bjp-14679	106	77	i	i	PRON
bjp-14679	106	78	(	(	PUNCT
bjp-14679	106	79	continued	continued	ADJ
bjp-14679	106	80	)	)	PUNCT
bjp-14679	106	81	amino	amino	NOUN
bjp-14679	106	82	acid	acid	NOUN
bjp-14679	106	83	change	change	NOUN
bjp-14679	106	84	tolerance	tolerance	NOUN
bjp-14679	106	85	index	index	NOUN
bjp-14679	106	86	psic	psic	ADJ
bjp-14679	106	87	sd	sd	PROPN
bjp-14679	106	88	prediction	prediction	NOUN
bjp-14679	106	89	ddg	ddg	PROPN
bjp-14679	106	90	(	(	PUNCT
bjp-14679	106	91	kcal	kcal	PROPN
bjp-14679	106	92	/	/	SYM
bjp-14679	106	93	mol	mol	NOUN
bjp-14679	106	94	)	)	PUNCT
bjp-14679	106	95	v473i	v473i	NOUN
bjp-14679	106	96	d72n	d72n	VERB
bjp-14679	106	97	0.13	0.13	NUM
bjp-14679	106	98	0.19	0.19	NUM
bjp-14679	106	99	0.977	0.977	NUM
bjp-14679	106	100	0.994	0.994	NUM
bjp-14679	106	101	probably	probably	ADV
bjp-14679	106	102	damaging	damage	VERB
bjp-14679	106	103	probably	probably	ADV
bjp-14679	106	104	damaging	damage	VERB
bjp-14679	106	105	-2.03	-2.03	PRON
bjp-14679	106	106	-1.77	-1.77	NUM
bjp-14679	106	107	v832	v832	NUM
bjp-14679	106	108	m	m	NOUN
bjp-14679	106	109	0.06	0.06	NUM
bjp-14679	106	110	1	1	NUM
bjp-14679	106	111	probably	probably	ADV
bjp-14679	106	112	damaging	damage	VERB
bjp-14679	106	113	-0.76	-0.76	PROPN
bjp-14679	106	114	l478p	l478p	PROPN
bjp-14679	106	115	0.27	0.27	NUM
bjp-14679	106	116	0.507	0.507	NUM
bjp-14679	106	117	possibly	possibly	ADV
bjp-14679	106	118	damaging	damage	VERB
bjp-14679	106	119	-1.59	-1.59	NOUN
bjp-14679	106	120	a592	a592	NOUN
bjp-14679	106	121	t	t	NOUN
bjp-14679	106	122	0.04	0.04	NUM
bjp-14679	106	123	0.492	0.492	NUM
bjp-14679	106	124	possibly	possibly	ADV
bjp-14679	106	125	damaging	damage	VERB
bjp-14679	106	126	-0.85	-0.85	NOUN
bjp-14679	106	127	e880k	e880k	ADP
bjp-14679	106	128	0.01	0.01	NUM
bjp-14679	106	129	0.495	0.495	NUM
bjp-14679	106	130	possibly	possibly	ADV
bjp-14679	106	131	damaging	damage	VERB
bjp-14679	106	132	-1.15	-1.15	DET
bjp-14679	106	133	i393n	i393n	PROPN
bjp-14679	106	134	0	0	NUM
bjp-14679	106	135	0.997	0.997	NUM
bjp-14679	106	136	probably	probably	ADV
bjp-14679	106	137	damaging	damage	VERB
bjp-14679	106	138	0.09	0.09	NUM
bjp-14679	106	139	n751k	n751k	PROPN
bjp-14679	106	140	0	0	NUM
bjp-14679	106	141	1	1	NUM
bjp-14679	106	142	probably	probably	ADV
bjp-14679	106	143	damaging	damage	VERB
bjp-14679	106	144	0.99	0.99	NUM
bjp-14679	106	145	a617	a617	PROPN
bjp-14679	106	146	t	t	NOUN
bjp-14679	106	147	0.67	0.67	NUM
bjp-14679	106	148	0.04	0.04	NUM
bjp-14679	106	149	benign	benign	ADJ
bjp-14679	106	150	-3.9	-3.9	NOUN
bjp-14679	106	151	c695r	c695r	ADP
bjp-14679	106	152	0.05	0.05	NUM
bjp-14679	106	153	1	1	NUM
bjp-14679	106	154	probably	probably	ADV
bjp-14679	106	155	damaging	damage	VERB
bjp-14679	106	156	-1.31	-1.31	VERB
bjp-14679	106	157	l630v	l630v	NOUN
bjp-14679	106	158	0.18	0.18	NUM
bjp-14679	106	159	0.998	0.998	NUM
bjp-14679	106	160	probably	probably	ADV
bjp-14679	106	161	damaging	damage	VERB
bjp-14679	106	162	-1.07	-1.07	ADJ
bjp-14679	106	163	advantages	advantage	NOUN
bjp-14679	106	164	and	and	CCONJ
bjp-14679	106	165	reliable	reliable	ADJ
bjp-14679	106	166	to	to	PART
bjp-14679	106	167	find	find	VERB
bjp-14679	106	168	out	out	ADP
bjp-14679	106	169	the	the	DET
bjp-14679	106	170	detrimental	detrimental	ADJ
bjp-14679	106	171	effect	effect	NOUN
bjp-14679	106	172	of	of	ADP
bjp-14679	106	173	missense	missense	NOUN
bjp-14679	106	174	mutations	mutation	NOUN
bjp-14679	106	175	(	(	PUNCT
bjp-14679	106	176	teng	teng	PROPN
bjp-14679	106	177	et	et	PROPN
bjp-14679	106	178	al	al	PROPN
bjp-14679	106	179	.	.	PROPN
bjp-14679	106	180	,	,	PUNCT
bjp-14679	106	181	2009	2009	NUM
bjp-14679	106	182	)	)	PUNCT
bjp-14679	106	183	.	.	PUNCT
bjp-14679	107	1	we	we	PRON
bjp-14679	107	2	rationally	rationally	ADV
bjp-14679	107	3	considered	consider	VERB
bjp-14679	107	4	the	the	DET
bjp-14679	107	5	10	10	NUM
bjp-14679	107	6	potential	potential	ADJ
bjp-14679	107	7	detrimental	detrimental	ADJ
bjp-14679	107	8	point	point	NOUN
bjp-14679	107	9	mutations	mutation	NOUN
bjp-14679	107	10	such	such	ADJ
bjp-14679	107	11	as	as	ADP
bjp-14679	107	12	e336d	e336d	PROPN
bjp-14679	107	13	,	,	PUNCT
bjp-14679	107	14	a298	a298	PROPN
bjp-14679	107	15	t	t	PROPN
bjp-14679	107	16	,	,	PUNCT
bjp-14679	107	17	p201r	p201r	PROPN
bjp-14679	107	18	,	,	PUNCT
bjp-14679	107	19	c695r	c695r	PROPN
bjp-14679	107	20	,	,	PUNCT
bjp-14679	107	21	g879s	g879s	PROPN
bjp-14679	107	22	,	,	PUNCT
bjp-14679	107	23	d882n	d882n	PROPN
bjp-14679	107	24	,	,	PUNCT
bjp-14679	107	25	y755c	y755c	PROPN
bjp-14679	107	26	,	,	PUNCT
bjp-14679	107	27	r169h	r169h	PROPN
bjp-14679	107	28	,	,	PUNCT
bjp-14679	107	29	d768n	d768n	PROPN
bjp-14679	107	30	and	and	CCONJ
bjp-14679	107	31	n751k	n751k	PROPN
bjp-14679	107	32	for	for	ADP
bjp-14679	107	33	further	further	ADJ
bjp-14679	107	34	course	course	NOUN
bjp-14679	107	35	of	of	ADP
bjp-14679	107	36	investigation	investigation	NOUN
bjp-14679	107	37	.	.	PUNCT
bjp-14679	108	1	they	they	PRON
bjp-14679	108	2	were	be	AUX
bjp-14679	108	3	commonly	commonly	ADV
bjp-14679	108	4	found	find	VERB
bjp-14679	108	5	to	to	PART
bjp-14679	108	6	be	be	AUX
bjp-14679	108	7	less	less	ADV
bjp-14679	108	8	stable	stable	ADJ
bjp-14679	108	9	,	,	PUNCT
bjp-14679	108	10	deleterious	deleterious	ADJ
bjp-14679	108	11	and	and	CCONJ
bjp-14679	108	12	damaging	damaging	ADJ
bjp-14679	108	13	by	by	ADP
bjp-14679	108	14	the	the	DET
bjp-14679	108	15	i	i	PROPN
bjp-14679	108	16	-	-	PUNCT
bjp-14679	108	17	mutant2.0	mutant2.0	PROPN
bjp-14679	108	18	,	,	PUNCT
bjp-14679	108	19	sift	sift	ADJ
bjp-14679	108	20	and	and	CCONJ
bjp-14679	108	21	polyphen	polyphen	ADJ
bjp-14679	108	22	programs	program	NOUN
bjp-14679	108	23	,	,	PUNCT
bjp-14679	108	24	respectively	respectively	ADV
bjp-14679	108	25	.	.	PUNCT
bjp-14679	109	1	it	it	PRON
bjp-14679	109	2	was	be	AUX
bjp-14679	109	3	interestingly	interestingly	ADV
bjp-14679	109	4	to	to	PART
bjp-14679	109	5	note	note	VERB
bjp-14679	109	6	that	that	SCONJ
bjp-14679	109	7	among	among	ADP
bjp-14679	109	8	these	these	DET
bjp-14679	109	9	10	10	NUM
bjp-14679	109	10	variants	variant	NOUN
bjp-14679	109	11	,	,	PUNCT
bjp-14679	109	12	e336d	e336d	PROPN
bjp-14679	109	13	and	and	CCONJ
bjp-14679	109	14	a298	a298	PROPN
bjp-14679	109	15	t	t	PROPN
bjp-14679	109	16	showed	show	VERB
bjp-14679	109	17	very	very	ADV
bjp-14679	109	18	good	good	ADJ
bjp-14679	109	19	agreement	agreement	NOUN
bjp-14679	109	20	with	with	ADP
bjp-14679	109	21	experimental	experimental	ADJ
bjp-14679	109	22	observation	observation	NOUN
bjp-14679	109	23	performed	perform	VERB
bjp-14679	109	24	elsewhere	elsewhere	ADV
bjp-14679	109	25	(	(	PUNCT
bjp-14679	109	26	berx	berx	NOUN
bjp-14679	109	27	et	et	PROPN
bjp-14679	109	28	al	al	PROPN
bjp-14679	109	29	.	.	PROPN
bjp-14679	109	30	,	,	PUNCT
bjp-14679	109	31	1998	1998	NUM
bjp-14679	109	32	;	;	PUNCT
bjp-14679	109	33	corso	corso	PROPN
bjp-14679	109	34	et	et	PROPN
bjp-14679	109	35	al	al	PROPN
bjp-14679	109	36	.	.	PROPN
bjp-14679	109	37	,	,	PUNCT
bjp-14679	109	38	2012	2012	NUM
bjp-14679	109	39	;	;	PUNCT
bjp-14679	110	1	oliveira	oliveira	PROPN
bjp-14679	110	2	et	et	PROPN
bjp-14679	110	3	al	al	PROPN
bjp-14679	110	4	.	.	PROPN
bjp-14679	110	5	,	,	PUNCT
bjp-14679	110	6	2004	2004	NUM
bjp-14679	110	7	;	;	PUNCT
bjp-14679	110	8	brooks	brooks	PROPN
bjp-14679	110	9	et	et	PROPN
bjp-14679	110	10	al	al	PROPN
bjp-14679	110	11	.	.	PROPN
bjp-14679	110	12	,	,	PUNCT
bjp-14679	110	13	2004	2004	NUM
bjp-14679	110	14	;	;	PUNCT
bjp-14679	110	15	kaurah	kaurah	PROPN
bjp-14679	110	16	et	et	PROPN
bjp-14679	110	17	al	al	PROPN
bjp-14679	110	18	.	.	PROPN
bjp-14679	110	19	,	,	PUNCT
bjp-14679	110	20	2007	2007	NUM
bjp-14679	110	21	)	)	PUNCT
bjp-14679	110	22	.	.	PUNCT
bjp-14679	111	1	in	in	ADP
bjp-14679	111	2	order	order	NOUN
bjp-14679	111	3	to	to	PART
bjp-14679	111	4	predict	predict	VERB
bjp-14679	111	5	the	the	DET
bjp-14679	111	6	human	human	ADJ
bjp-14679	111	7	disease	disease	NOUN
bjp-14679	111	8	related	relate	VERB
bjp-14679	111	9	single	single	ADJ
bjp-14679	111	10	point	point	NOUN
bjp-14679	111	11	protein	protein	NOUN
bjp-14679	111	12	mutations	mutation	NOUN
bjp-14679	111	13	we	we	PRON
bjp-14679	111	14	used	use	VERB
bjp-14679	111	15	snps	snps	PROPN
bjp-14679	111	16	and	and	CCONJ
bjp-14679	111	17	go	go	VERB
bjp-14679	111	18	program	program	NOUN
bjp-14679	111	19	(	(	PUNCT
bjp-14679	111	20	calabrese	calabrese	PROPN
bjp-14679	111	21	et	et	PROPN
bjp-14679	111	22	al	al	PROPN
bjp-14679	111	23	.	.	PROPN
bjp-14679	111	24	,	,	PUNCT
bjp-14679	111	25	2009	2009	NUM
bjp-14679	111	26	)	)	PUNCT
bjp-14679	111	27	to	to	PART
bjp-14679	111	28	predict	predict	VERB
bjp-14679	111	29	a	a	DET
bjp-14679	111	30	particular	particular	ADJ
bjp-14679	111	31	variant	variant	NOUN
bjp-14679	111	32	is	be	AUX
bjp-14679	111	33	disease	disease	NOUN
bjp-14679	111	34	related	relate	VERB
bjp-14679	111	35	or	or	CCONJ
bjp-14679	111	36	neutral	neutral	ADJ
bjp-14679	111	37	.	.	PUNCT
bjp-14679	112	1	among	among	ADP
bjp-14679	112	2	the	the	DET
bjp-14679	112	3	10	10	NUM
bjp-14679	112	4	detrimental	detrimental	ADJ
bjp-14679	112	5	missense	missense	NOUN
bjp-14679	112	6	mutations	mutation	NOUN
bjp-14679	112	7	4	4	NUM
bjp-14679	112	8	variants	variant	NOUN
bjp-14679	112	9	namely	namely	ADV
bjp-14679	112	10	,	,	PUNCT
bjp-14679	112	11	e336d	e336d	PROPN
bjp-14679	112	12	,	,	PUNCT
bjp-14679	112	13	a298	a298	PROPN
bjp-14679	112	14	t	t	PROPN
bjp-14679	112	15	,	,	PUNCT
bjp-14679	112	16	201r	201r	PROPN
bjp-14679	112	17	and	and	CCONJ
bjp-14679	112	18	r169h	r169h	PROPN
bjp-14679	112	19	found	find	VERB
bjp-14679	112	20	to	to	PART
bjp-14679	112	21	be	be	AUX
bjp-14679	112	22	diseased	disease	VERB
bjp-14679	112	23	and	and	CCONJ
bjp-14679	112	24	the	the	DET
bjp-14679	112	25	remaining	remain	VERB
bjp-14679	112	26	6	6	NUM
bjp-14679	112	27	variants	variant	NOUN
bjp-14679	112	28	predicted	predict	VERB
bjp-14679	112	29	to	to	PART
bjp-14679	112	30	be	be	AUX
bjp-14679	112	31	neutral	neutral	ADJ
bjp-14679	112	32	by	by	ADP
bjp-14679	112	33	snps	snps	PROPN
bjp-14679	112	34	and	and	CCONJ
bjp-14679	112	35	go	go	VERB
bjp-14679	112	36	program	program	NOUN
bjp-14679	112	37	.	.	PUNCT
bjp-14679	113	1	the	the	DET
bjp-14679	113	2	result	result	NOUN
bjp-14679	113	3	is	be	AUX
bjp-14679	113	4	shown	show	VERB
bjp-14679	113	5	in	in	ADP
bjp-14679	113	6	table	table	NOUN
bjp-14679	113	7	ii	ii	PROPN
bjp-14679	113	8	.	.	PUNCT
bjp-14679	114	1	we	we	PRON
bjp-14679	114	2	observed	observe	VERB
bjp-14679	114	3	that	that	SCONJ
bjp-14679	114	4	,	,	PUNCT
bjp-14679	114	5	out	out	ADP
bjp-14679	114	6	of	of	ADP
bjp-14679	114	7	10	10	NUM
bjp-14679	114	8	variants	variant	NOUN
bjp-14679	114	9	,	,	PUNCT
bjp-14679	114	10	4	4	NUM
bjp-14679	114	11	variants	variant	NOUN
bjp-14679	114	12	were	be	AUX
bjp-14679	114	13	aving	ave	VERB
bjp-14679	114	14	ri	ri	ADP
bjp-14679	114	15	of	of	ADP
bjp-14679	114	16	>	>	SYM
bjp-14679	114	17	5	5	NUM
bjp-14679	114	18	reveal	reveal	VERB
bjp-14679	114	19	the	the	DET
bjp-14679	114	20	disease	disease	NOUN
bjp-14679	114	21	related	relate	VERB
bjp-14679	114	22	effect	effect	NOUN
bjp-14679	114	23	and	and	CCONJ
bjp-14679	114	24	the	the	DET
bjp-14679	114	25	remaining	remain	VERB
bjp-14679	114	26	6	6	NUM
bjp-14679	114	27	variants	variant	NOUN
bjp-14679	114	28	were	be	AUX
bjp-14679	114	29	having	have	VERB
bjp-14679	114	30	ri	ri	NOUN
bjp-14679	114	31	of	of	ADP
bjp-14679	114	32	<	<	X
bjp-14679	114	33	5	5	NUM
bjp-14679	114	34	indicate	indicate	VERB
bjp-14679	114	35	relatively	relatively	ADV
bjp-14679	114	36	the	the	DET
bjp-14679	114	37	neutral	neutral	ADJ
bjp-14679	114	38	effect	effect	NOUN
bjp-14679	114	39	.	.	PUNCT
bjp-14679	115	1	the	the	DET
bjp-14679	115	2	four	four	NUM
bjp-14679	115	3	detrimental	detrimental	ADJ
bjp-14679	115	4	structure	structure	NOUN
bjp-14679	115	5	of	of	ADP
bjp-14679	115	6	cdh1	cdh1	NOUN
bjp-14679	115	7	were	be	AUX
bjp-14679	115	8	generated	generate	VERB
bjp-14679	115	9	by	by	ADP
bjp-14679	115	10	means	mean	NOUN
bjp-14679	115	11	of	of	ADP
bjp-14679	115	12	swiss	swiss	ADJ
bjp-14679	115	13	model	model	NOUN
bjp-14679	115	14	program	program	NOUN
bjp-14679	115	15	.	.	PUNCT
bjp-14679	116	1	the	the	DET
bjp-14679	116	2	mutant	mutant	ADJ
bjp-14679	116	3	structures	structure	NOUN
bjp-14679	116	4	(	(	PUNCT
bjp-14679	116	5	e336d	e336d	PROPN
bjp-14679	116	6	,	,	PUNCT
bjp-14679	116	7	a298	a298	PROPN
bjp-14679	116	8	t	t	PROPN
bjp-14679	116	9	,	,	PUNCT
bjp-14679	116	10	p201r	p201r	PROPN
bjp-14679	116	11	and	and	CCONJ
bjp-14679	116	12	r169h	r169h	PROPN
bjp-14679	116	13	)	)	PUNCT
bjp-14679	116	14	were	be	AUX
bjp-14679	116	15	generated	generate	VERB
bjp-14679	116	16	by	by	ADP
bjp-14679	116	17	swisspdb	swisspdb	PROPN
bjp-14679	116	18	viewer	viewer	PROPN
bjp-14679	116	19	.	.	PUNCT
bjp-14679	117	1	the	the	DET
bjp-14679	117	2	pymol	pymol	PROPN
bjp-14679	117	3	view	view	NOUN
bjp-14679	117	4	of	of	ADP
bjp-14679	117	5	the	the	DET
bjp-14679	117	6	modelled	model	VERB
bjp-14679	117	7	structures	structure	NOUN
bjp-14679	117	8	of	of	ADP
bjp-14679	117	9	e	e	NOUN
bjp-14679	117	10	-	-	NOUN
bjp-14679	117	11	cadherin	cadherin	NOUN
bjp-14679	117	12	is	be	AUX
bjp-14679	117	13	shown	show	VERB
bjp-14679	117	14	in	in	ADP
bjp-14679	117	15	figure	figure	NOUN
bjp-14679	117	16	1	1	NUM
bjp-14679	117	17	.	.	PUNCT
bjp-14679	118	1	in	in	ADP
bjp-14679	118	2	order	order	NOUN
bjp-14679	118	3	to	to	PART
bjp-14679	118	4	find	find	VERB
bjp-14679	118	5	out	out	ADP
bjp-14679	118	6	the	the	DET
bjp-14679	118	7	deviation	deviation	NOUN
bjp-14679	118	8	between	between	ADP
bjp-14679	118	9	the	the	DET
bjp-14679	118	10	two	two	NUM
bjp-14679	118	11	structures	structure	NOUN
bjp-14679	118	12	,	,	PUNCT
bjp-14679	118	13	we	we	PRON
bjp-14679	118	14	superimposed	superimpose	VERB
bjp-14679	118	15	the	the	DET
bjp-14679	118	16	energy	energy	NOUN
bjp-14679	118	17	refined	refine	VERB
bjp-14679	118	18	native	native	ADJ
bjp-14679	118	19	structure	structure	NOUN
bjp-14679	118	20	with	with	ADP
bjp-14679	118	21	all	all	DET
bjp-14679	118	22	the	the	DET
bjp-14679	118	23	energy	energy	NOUN
bjp-14679	118	24	refined	refine	VERB
bjp-14679	118	25	mutant	mutant	ADJ
bjp-14679	118	26	structures	structure	NOUN
bjp-14679	118	27	to	to	PART
bjp-14679	118	28	get	get	VERB
bjp-14679	118	29	rmsd	rmsd	NOUN
bjp-14679	118	30	.	.	PUNCT
bjp-14679	119	1	the	the	PRON
bjp-14679	119	2	higher	high	ADJ
bjp-14679	119	3	the	the	DET
bjp-14679	119	4	rmsd	rmsd	NOUN
bjp-14679	119	5	value	value	NOUN
bjp-14679	119	6	,	,	PUNCT
bjp-14679	119	7	the	the	DET
bjp-14679	119	8	more	more	ADJ
bjp-14679	119	9	is	be	AUX
bjp-14679	119	10	the	the	DET
bjp-14679	119	11	deviation	deviation	NOUN
bjp-14679	119	12	between	between	ADP
bjp-14679	119	13	the	the	DET
bjp-14679	119	14	native	native	NOUN
bjp-14679	119	15	and	and	CCONJ
bjp-14679	119	16	the	the	DET
bjp-14679	119	17	mutant	mutant	ADJ
bjp-14679	119	18	structure	structure	NOUN
bjp-14679	119	19	,	,	PUNCT
bjp-14679	119	20	which	which	PRON
bjp-14679	119	21	in	in	ADP
bjp-14679	119	22	turn	turn	NOUN
bjp-14679	119	23	changes	change	VERB
bjp-14679	119	24	their	their	PRON
bjp-14679	119	25	binding	bind	VERB
bjp-14679	119	26	efficiency	efficiency	NOUN
bjp-14679	119	27	with	with	ADP
bjp-14679	119	28	inhibitors	inhibitor	NOUN
bjp-14679	119	29	due	due	ADP
bjp-14679	119	30	to	to	ADP
bjp-14679	119	31	deviation	deviation	NOUN
bjp-14679	119	32	in	in	ADP
bjp-14679	119	33	3d	3d	NUM
bjp-14679	119	34	space	space	NOUN
bjp-14679	119	35	of	of	ADP
bjp-14679	119	36	the	the	DET
bjp-14679	119	37	binding	bind	VERB
bjp-14679	119	38	residues	residue	NOUN
bjp-14679	119	39	of	of	ADP
bjp-14679	119	40	cdh1	cdh1	NOUN
bjp-14679	119	41	gene	gene	NOUN
bjp-14679	119	42	.	.	PUNCT
bjp-14679	120	1	table	table	NOUN
bjp-14679	120	2	iii	iii	PROPN
bjp-14679	120	3	shows	show	VERB
bjp-14679	120	4	the	the	DET
bjp-14679	120	5	rmsd	rmsd	NOUN
bjp-14679	120	6	for	for	ADP
bjp-14679	120	7	native	native	ADJ
bjp-14679	120	8	structure	structure	NOUN
bjp-14679	120	9	with	with	ADP
bjp-14679	120	10	all	all	DET
bjp-14679	120	11	the	the	DET
bjp-14679	120	12	mutant	mutant	ADJ
bjp-14679	120	13	modelled	model	VERB
bjp-14679	120	14	structures	structure	NOUN
bjp-14679	120	15	.	.	PUNCT
bjp-14679	121	1	the	the	DET
bjp-14679	121	2	value	value	NOUN
bjp-14679	121	3	is	be	AUX
bjp-14679	121	4	of	of	ADP
bjp-14679	121	5	0.015	0.015	NUM
bjp-14679	121	6	å	å	PROPN
bjp-14679	121	7	,	,	PUNCT
bjp-14679	121	8	0.105	0.105	NUM
bjp-14679	121	9	å	å	PROPN
bjp-14679	121	10	,	,	PUNCT
bjp-14679	121	11	3.617å	3.617å	NUM
bjp-14679	121	12	and	and	CCONJ
bjp-14679	121	13	0.028	0.028	NUM
bjp-14679	121	14	å	å	PROPN
bjp-14679	121	15	for	for	ADP
bjp-14679	121	16	the	the	DET
bjp-14679	121	17	e336d	e336d	PROPN
bjp-14679	121	18	,	,	PUNCT
bjp-14679	121	19	a298	a298	PROPN
bjp-14679	121	20	t	t	PROPN
bjp-14679	121	21	,	,	PUNCT
bjp-14679	121	22	p201r	p201r	PROPN
bjp-14679	121	23	and	and	CCONJ
bjp-14679	121	24	r169h	r169h	PROPN
bjp-14679	121	25	structures	structure	NOUN
bjp-14679	121	26	respectively	respectively	ADV
bjp-14679	121	27	.	.	PUNCT
bjp-14679	122	1	finally	finally	ADV
bjp-14679	122	2	,	,	PUNCT
bjp-14679	122	3	the	the	DET
bjp-14679	122	4	molecular	molecular	ADJ
bjp-14679	122	5	docking	docking	NOUN
bjp-14679	122	6	studies	study	NOUN
bjp-14679	122	7	were	be	AUX
bjp-14679	122	8	performed	perform	VERB
bjp-14679	122	9	to	to	PART
bjp-14679	122	10	confirm	confirm	VERB
bjp-14679	122	11	the	the	DET
bjp-14679	122	12	functional	functional	ADJ
bjp-14679	122	13	impact	impact	NOUN
bjp-14679	122	14	of	of	ADP
bjp-14679	122	15	the	the	DET
bjp-14679	122	16	amino	amino	NOUN
bjp-14679	122	17	acid	acid	NOUN
bjp-14679	122	18	mutation	mutation	NOUN
bjp-14679	122	19	.	.	PUNCT
bjp-14679	123	1	cetuximab	cetuximab	NOUN
bjp-14679	123	2	(	(	PUNCT
bjp-14679	123	3	pdb	pdb	PROPN
bjp-14679	123	4	i	i	PROPN
bjp-14679	123	5	d	d	PROPN
bjp-14679	123	6	:	:	PUNCT
bjp-14679	123	7	1yy8	1yy8	NUM
bjp-14679	123	8	)	)	PUNCT
bjp-14679	123	9	structure	structure	NOUN
bjp-14679	123	10	was	be	AUX
bjp-14679	123	11	retrieved	retrieve	VERB
bjp-14679	123	12	from	from	ADP
bjp-14679	123	13	pdb	pdb	PROPN
bjp-14679	123	14	.	.	PUNCT
bjp-14679	124	1	it	it	PRON
bjp-14679	124	2	is	be	AUX
bjp-14679	124	3	docked	dock	VERB
bjp-14679	124	4	with	with	ADP
bjp-14679	124	5	native	native	ADJ
bjp-14679	124	6	and	and	CCONJ
bjp-14679	124	7	mutant	mutant	ADJ
bjp-14679	124	8	(	(	PUNCT
bjp-14679	124	9	e336d	e336d	PROPN
bjp-14679	124	10	,	,	PUNCT
bjp-14679	124	11	a298	a298	PROPN
bjp-14679	124	12	t	t	PROPN
bjp-14679	124	13	,	,	PUNCT
bjp-14679	124	14	p201r	p201r	PROPN
bjp-14679	124	15	and	and	CCONJ
bjp-14679	124	16	r169h	r169h	PROPN
bjp-14679	124	17	)	)	PUNCT
bjp-14679	124	18	structures	structure	NOUN
bjp-14679	124	19	of	of	ADP
bjp-14679	124	20	e	e	NOUN
bjp-14679	124	21	-	-	NOUN
bjp-14679	124	22	cadherin	cadherin	NOUN
bjp-14679	124	23	to	to	PART
bjp-14679	124	24	understand	understand	VERB
bjp-14679	124	25	the	the	DET
bjp-14679	124	26	binding	bind	VERB
bjp-14679	124	27	affinity	affinity	NOUN
bjp-14679	124	28	.	.	PUNCT
bjp-14679	125	1	docking	docking	NOUN
bjp-14679	125	2	was	be	AUX
bjp-14679	125	3	performed	perform	VERB
bjp-14679	125	4	using	use	VERB
bjp-14679	125	5	the	the	DET
bjp-14679	125	6	firedock	firedock	ADJ
bjp-14679	125	7	program	program	NOUN
bjp-14679	125	8	(	(	PUNCT
bjp-14679	125	9	mashiach	mashiach	PROPN
bjp-14679	125	10	et	et	PROPN
bjp-14679	125	11	al	al	PROPN
bjp-14679	125	12	.	.	PROPN
bjp-14679	125	13	,	,	PUNCT
bjp-14679	125	14	2008	2008	NUM
bjp-14679	125	15	)	)	PUNCT
bjp-14679	125	16	.	.	PUNCT
bjp-14679	126	1	the	the	DET
bjp-14679	126	2	result	result	NOUN
bjp-14679	126	3	is	be	AUX
bjp-14679	126	4	shown	show	VERB
bjp-14679	126	5	from	from	ADP
bjp-14679	126	6	figure	figure	NOUN
bjp-14679	126	7	2	2	NUM
bjp-14679	126	8	.	.	PUNCT
bjp-14679	127	1	the	the	DET
bjp-14679	127	2	analysis	analysis	NOUN
bjp-14679	127	3	indicates	indicate	VERB
bjp-14679	127	4	the	the	DET
bjp-14679	127	5	affinity	affinity	NOUN
bjp-14679	127	6	for	for	ADP
bjp-14679	127	7	cetuximab	cetuximab	NOUN
bjp-14679	127	8	for	for	ADP
bjp-14679	127	9	native	native	ADJ
bjp-14679	127	10	cdh1	cdh1	PROPN
bjp-14679	127	11	was	be	AUX
bjp-14679	127	12	found	find	VERB
bjp-14679	127	13	to	to	PART
bjp-14679	127	14	be	be	AUX
bjp-14679	127	15	-52.3	-52.3	NUM
bjp-14679	127	16	kcal	kcal	NOUN
bjp-14679	127	17	/	/	SYM
bjp-14679	127	18	mol	mol	NOUN
bjp-14679	127	19	,	,	PUNCT
bjp-14679	127	20	whereas	whereas	SCONJ
bjp-14679	127	21	with	with	ADP
bjp-14679	127	22	the	the	DET
bjp-14679	127	23	mutants	mutant	NOUN
bjp-14679	127	24	,	,	PUNCT
bjp-14679	127	25	the	the	DET
bjp-14679	127	26	dg	dg	NOUN
bjp-14679	127	27	was	be	AUX
bjp-14679	127	28	found	find	VERB
bjp-14679	127	29	to	to	PART
bjp-14679	127	30	be	be	AUX
bjp-14679	127	31	in	in	ADP
bjp-14679	127	32	the	the	DET
bjp-14679	127	33	ranges	range	NOUN
bjp-14679	127	34	–	–	PUNCT
bjp-14679	127	35	30.0	30.0	NUM
bjp-14679	127	36	to	to	ADP
bjp-14679	127	37	-45	-45	PUNCT
bjp-14679	127	38	kcal	kcal	PROPN
bjp-14679	127	39	/	/	SYM
bjp-14679	127	40	mol	mol	PROPN
bjp-14679	127	41	.	.	PUNCT
bjp-14679	128	1	it	it	PRON
bjp-14679	128	2	can	can	AUX
bjp-14679	128	3	be	be	AUX
bjp-14679	128	4	seen	see	VERB
bjp-14679	128	5	from	from	ADP
bjp-14679	128	6	figure	figure	NOUN
bjp-14679	128	7	2	2	NUM
bjp-14679	128	8	,	,	PUNCT
bjp-14679	128	9	the	the	DET
bjp-14679	128	10	mutants	mutant	NOUN
bjp-14679	128	11	established	establish	VERB
bjp-14679	128	12	lesser	less	ADJ
bjp-14679	128	13	binding	bind	VERB
bjp-14679	128	14	affinity	affinity	NOUN
bjp-14679	128	15	with	with	ADP
bjp-14679	128	16	cetuximab	cetuximab	NOUN
bjp-14679	128	17	than	than	ADP
bjp-14679	128	18	the	the	DET
bjp-14679	128	19	native	native	ADJ
bjp-14679	128	20	type	type	NOUN
bjp-14679	128	21	protein	protein	NOUN
bjp-14679	128	22	.	.	PUNCT
bjp-14679	129	1	these	these	DET
bjp-14679	129	2	data	datum	NOUN
bjp-14679	129	3	clearly	clearly	ADV
bjp-14679	129	4	portray	portray	VERB
bjp-14679	129	5	that	that	SCONJ
bjp-14679	129	6	mutation	mutation	NOUN
bjp-14679	129	7	in	in	ADP
bjp-14679	129	8	the	the	DET
bjp-14679	129	9	e	e	NOUN
bjp-14679	129	10	-	-	NOUN
bjp-14679	129	11	cadherin	cadherin	NOUN
bjp-14679	129	12	structure	structure	NOUN
bjp-14679	129	13	leads	lead	VERB
bjp-14679	129	14	to	to	ADP
bjp-14679	129	15	the	the	DET
bjp-14679	129	16	resistance	resistance	NOUN
bjp-14679	129	17	for	for	ADP
bjp-14679	129	18	cetuximab	cetuximab	NOUN
bjp-14679	129	19	.	.	PUNCT
bjp-14679	130	1	this	this	PRON
bjp-14679	130	2	is	be	AUX
bjp-14679	130	3	the	the	DET
bjp-14679	130	4	clear	clear	ADJ
bjp-14679	130	5	evidence	evidence	NOUN
bjp-14679	130	6	of	of	ADP
bjp-14679	130	7	the	the	DET
bjp-14679	130	8	deleterious	deleterious	ADJ
bjp-14679	130	9	effect	effect	NOUN
bjp-14679	130	10	of	of	ADP
bjp-14679	130	11	missense	missense	NOUN
bjp-14679	130	12	mutations	mutation	NOUN
bjp-14679	130	13	such	such	ADJ
bjp-14679	130	14	as	as	ADP
bjp-14679	130	15	e336d	e336d	PROPN
bjp-14679	130	16	,	,	PUNCT
bjp-14679	130	17	a298	a298	PROPN
bjp-14679	130	18	t	t	PROPN
bjp-14679	130	19	,	,	PUNCT
bjp-14679	130	20	p201r	p201r	PROPN
bjp-14679	130	21	and	and	CCONJ
bjp-14679	130	22	r169h	r169h	PROPN
bjp-14679	130	23	lesser	less	ADJ
bjp-14679	130	24	.	.	PUNCT
bjp-14679	131	1	hence	hence	ADV
bjp-14679	131	2	,	,	PUNCT
bjp-14679	131	3	we	we	PRON
bjp-14679	131	4	conclude	conclude	VERB
bjp-14679	131	5	that	that	SCONJ
bjp-14679	131	6	these	these	DET
bjp-14679	131	7	variants	variant	NOUN
bjp-14679	131	8	should	should	AUX
bjp-14679	131	9	also	also	ADV
bjp-14679	131	10	consider	consider	VERB
bjp-14679	131	11	for	for	ADP
bjp-14679	131	12	the	the	DET
bjp-14679	131	13	design	design	NOUN
bjp-14679	131	14	of	of	ADP
bjp-14679	131	15	drug	drug	NOUN
bjp-14679	131	16	for	for	ADP
bjp-14679	131	17	the	the	DET
bjp-14679	131	18	treatment	treatment	NOUN
bjp-14679	131	19	of	of	ADP
bjp-14679	131	20	hdgc	hdgc	NOUN
bjp-14679	131	21	.	.	PUNCT
bjp-14679	132	1	the	the	DET
bjp-14679	132	2	mutations	mutation	NOUN
bjp-14679	132	3	of	of	ADP
bjp-14679	132	4	cdh1	cdh1	NOUN
bjp-14679	132	5	namely	namely	ADV
bjp-14679	132	6	e336d	e336d	PROPN
bjp-14679	132	7	and	and	CCONJ
bjp-14679	132	8	a298	a298	PROPN
bjp-14679	132	9	t	t	PROPN
bjp-14679	132	10	were	be	AUX
bjp-14679	132	11	proved	prove	VERB
bjp-14679	132	12	more	more	ADV
bjp-14679	132	13	deleterious	deleterious	ADJ
bjp-14679	132	14	effect	effect	NOUN
bjp-14679	132	15	to	to	ADP
bjp-14679	132	16	the	the	DET
bjp-14679	132	17	structural	structural	ADJ
bjp-14679	132	18	stability	stability	NOUN
bjp-14679	132	19	and	and	CCONJ
bjp-14679	132	20	its	its	PRON
bjp-14679	132	21	function	function	NOUN
bjp-14679	132	22	of	of	ADP
bjp-14679	132	23	the	the	DET
bjp-14679	132	24	e	e	NOUN
bjp-14679	132	25	-	-	NOUN
bjp-14679	132	26	catherin	catherin	NOUN
bjp-14679	132	27	.	.	PUNCT
bjp-14679	133	1	in	in	ADP
bjp-14679	133	2	this	this	DET
bjp-14679	133	3	work	work	NOUN
bjp-14679	133	4	,	,	PUNCT
bjp-14679	133	5	we	we	PRON
bjp-14679	133	6	also	also	ADV
bjp-14679	133	7	found	find	VERB
bjp-14679	133	8	quite	quite	DET
bjp-14679	133	9	a	a	DET
bjp-14679	133	10	few	few	ADJ
bjp-14679	133	11	other	other	ADJ
bjp-14679	133	12	drug	drug	NOUN
bjp-14679	133	13	-	-	PUNCT
bjp-14679	133	14	resistant	resistant	ADJ
bjp-14679	133	15	mutations	mutation	NOUN
bjp-14679	133	16	by	by	ADP
bjp-14679	133	17	computational	computational	ADJ
bjp-14679	133	18	approach	approach	NOUN
bjp-14679	133	19	.	.	PUNCT
bjp-14679	134	1	we	we	PRON
bjp-14679	134	2	believe	believe	VERB
bjp-14679	134	3	that	that	SCONJ
bjp-14679	134	4	our	our	PRON
bjp-14679	134	5	observations	observation	NOUN
bjp-14679	134	6	have	have	VERB
bjp-14679	134	7	critical	critical	ADJ
bjp-14679	134	8	implications	implication	NOUN
bjp-14679	134	9	for	for	ADP
bjp-14679	134	10	the	the	DET
bjp-14679	134	11	understanding	understanding	NOUN
bjp-14679	134	12	of	of	ADP
bjp-14679	134	13	cdh1	cdh1	NOUN
bjp-14679	134	14	associated	associate	VERB
bjp-14679	134	15	missense	missense	NOUN
bjp-14679	134	16	mutations	mutation	NOUN
bjp-14679	134	17	and	and	CCONJ
bjp-14679	134	18	also	also	ADV
bjp-14679	134	19	for	for	ADP
bjp-14679	134	20	the	the	DET
bjp-14679	134	21	development	development	NOUN
bjp-14679	134	22	of	of	ADP
bjp-14679	134	23	novel	novel	ADJ
bjp-14679	134	24	therapies	therapy	NOUN
bjp-14679	134	25	for	for	ADP
bjp-14679	134	26	this	this	DET
bjp-14679	134	27	disease	disease	NOUN
bjp-14679	134	28	.	.	PUNCT
bjp-14679	135	1	acknowledgement	acknowledgement	NOUN
bjp-14679	135	2	the	the	DET
bjp-14679	135	3	authors	author	NOUN
bjp-14679	135	4	would	would	AUX
bjp-14679	135	5	like	like	VERB
bjp-14679	135	6	to	to	PART
bjp-14679	135	7	thank	thank	VERB
bjp-14679	135	8	the	the	DET
bjp-14679	135	9	school	school	NOUN
bjp-14679	135	10	of	of	ADP
bjp-14679	135	11	biosciences	bioscience	NOUN
bjp-14679	135	12	and	and	CCONJ
bjp-14679	135	13	technology	technology	NOUN
bjp-14679	135	14	,	,	PUNCT
bjp-14679	135	15	vit	vit	PROPN
bjp-14679	135	16	university	university	NOUN
bjp-14679	135	17	for	for	ADP
bjp-14679	135	18	providing	provide	VERB
bjp-14679	135	19	the	the	DET
bjp-14679	135	20	facilities	facility	NOUN
bjp-14679	135	21	to	to	PART
bjp-14679	135	22	carry	carry	VERB
bjp-14679	135	23	out	out	ADP
bjp-14679	135	24	this	this	DET
bjp-14679	135	25	work	work	NOUN
bjp-14679	135	26	.	.	PUNCT
bjp-14679	136	1	references	reference	NOUN
bjp-14679	136	2	arnold	arnold	PROPN
bjp-14679	136	3	k	k	PROPN
bjp-14679	136	4	,	,	PUNCT
bjp-14679	136	5	bordoli	bordoli	ADJ
bjp-14679	136	6	l	l	PROPN
bjp-14679	136	7	,	,	PUNCT
bjp-14679	136	8	kopp	kopp	PROPN
bjp-14679	136	9	j	j	PROPN
bjp-14679	136	10	,	,	PUNCT
bjp-14679	136	11	schwede	schwede	NOUN
bjp-14679	136	12	t.	t.	NOUN
bjp-14679	136	13	the	the	DET
bjp-14679	136	14	swiss	swiss	ADJ
bjp-14679	136	15	-	-	PUNCT
bjp-14679	136	16	model	model	NOUN
bjp-14679	136	17	workspace	workspace	NOUN
bjp-14679	136	18	:	:	PUNCT
bjp-14679	136	19	a	a	DET
bjp-14679	136	20	web	web	NOUN
bjp-14679	136	21	-	-	PUNCT
bjp-14679	136	22	based	base	VERB
bjp-14679	136	23	environment	environment	NOUN
bjp-14679	136	24	for	for	ADP
bjp-14679	136	25	protein	protein	NOUN
bjp-14679	136	26	structure	structure	NOUN
bjp-14679	136	27	homology	homology	NOUN
bjp-14679	136	28	modeling	modeling	NOUN
bjp-14679	136	29	.	.	PUNCT
bjp-14679	137	1	bioinformatics	bioinformatic	NOUN
bjp-14679	137	2	2006	2006	NUM
bjp-14679	137	3	;	;	PUNCT
bjp-14679	137	4	22	22	NUM
bjp-14679	137	5	:	:	SYM
bjp-14679	137	6	195	195	NUM
bjp-14679	137	7	-	-	PUNCT
bjp-14679	137	8	201	201	NUM
bjp-14679	137	9	.	.	PUNCT
bjp-14679	138	1	berman	berman	PROPN
bjp-14679	138	2	hm	hm	PROPN
bjp-14679	138	3	,	,	PUNCT
bjp-14679	138	4	westbrook	westbrook	PROPN
bjp-14679	138	5	j	j	PROPN
bjp-14679	138	6	,	,	PUNCT
bjp-14679	138	7	feng	feng	PROPN
bjp-14679	138	8	z	z	PROPN
bjp-14679	138	9	,	,	PUNCT
bjp-14679	138	10	gilliland	gilliland	VERB
bjp-14679	138	11	g	g	PROPN
bjp-14679	138	12	,	,	PUNCT
bjp-14679	138	13	bhat	bhat	PROPN
bjp-14679	138	14	tn	tn	PROPN
bjp-14679	138	15	,	,	PUNCT
bjp-14679	138	16	weissig	weissig	ADJ
bjp-14679	138	17	h	h	NOUN
bjp-14679	138	18	,	,	PUNCT
bjp-14679	138	19	shindyalov	shindyalov	VERB
bjp-14679	138	20	in	in	ADV
bjp-14679	138	21	,	,	PUNCT
bjp-14679	138	22	bourne	bourne	NOUN
bjp-14679	138	23	pe	pe	PROPN
bjp-14679	138	24	.	.	PUNCT
bjp-14679	139	1	the	the	DET
bjp-14679	139	2	protein	protein	NOUN
bjp-14679	139	3	data	data	PROPN
bjp-14679	139	4	bank	bank	NOUN
bjp-14679	139	5	.	.	PUNCT
bjp-14679	140	1	nucleic	nucleic	ADJ
bjp-14679	140	2	acids	acid	NOUN
bjp-14679	140	3	res	re	NOUN
bjp-14679	140	4	.	.	PROPN
bjp-14679	140	5	2000	2000	NUM
bjp-14679	140	6	;	;	PUNCT
bjp-14679	140	7	28	28	NUM
bjp-14679	140	8	:	:	SYM
bjp-14679	140	9	235	235	NUM
bjp-14679	140	10	-	-	SYM
bjp-14679	140	11	42	42	NUM
bjp-14679	140	12	.	.	PUNCT
bjp-14679	141	1	berx	berx	PROPN
bjp-14679	141	2	g	g	PROPN
bjp-14679	141	3	,	,	PUNCT
bjp-14679	141	4	becker	becker	PROPN
bjp-14679	141	5	kf	kf	PROPN
bjp-14679	141	6	,	,	PUNCT
bjp-14679	141	7	höfler	höfler	NOUN
bjp-14679	141	8	h	h	NOUN
bjp-14679	141	9	,	,	PUNCT
bjp-14679	141	10	van	van	PROPN
bjp-14679	141	11	roy	roy	PROPN
bjp-14679	141	12	f.	f.	PROPN
bjp-14679	141	13	mutations	mutation	NOUN
bjp-14679	141	14	of	of	ADP
bjp-14679	141	15	the	the	DET
bjp-14679	141	16	human	human	ADJ
bjp-14679	141	17	e	e	NOUN
bjp-14679	141	18	-	-	NOUN
bjp-14679	141	19	cadherin	cadherin	NOUN
bjp-14679	141	20	(	(	PUNCT
bjp-14679	141	21	cdh1	cdh1	NOUN
bjp-14679	141	22	)	)	PUNCT
bjp-14679	141	23	gene	gene	NOUN
bjp-14679	141	24	.	.	PUNCT
bjp-14679	142	1	human	human	ADJ
bjp-14679	142	2	mutation	mutation	NOUN
bjp-14679	142	3	.	.	PUNCT
bjp-14679	143	1	1998	1998	NUM
bjp-14679	143	2	;	;	PUNCT
bjp-14679	143	3	212	212	NUM
bjp-14679	143	4	bangladesh	bangladesh	NOUN
bjp-14679	143	5	j	j	PROPN
bjp-14679	143	6	pharmacol	pharmacol	PROPN
bjp-14679	143	7	2013	2013	NUM
bjp-14679	143	8	;	;	PUNCT
bjp-14679	143	9	8	8	NUM
bjp-14679	143	10	:	:	SYM
bjp-14679	143	11	207	207	NUM
bjp-14679	143	12	-	-	SYM
bjp-14679	143	13	213	213	NUM
bjp-14679	143	14	table	table	NOUN
bjp-14679	143	15	iii	iii	NOUN
bjp-14679	143	16	rmsd	rmsd	NOUN
bjp-14679	143	17	for	for	ADP
bjp-14679	143	18	native	native	ADJ
bjp-14679	143	19	and	and	CCONJ
bjp-14679	143	20	mutant	mutant	ADJ
bjp-14679	143	21	structures	structure	NOUN
bjp-14679	143	22	structure	structure	NOUN
bjp-14679	143	23	rmsd	rmsd	NOUN
bjp-14679	143	24	(	(	PUNCT
bjp-14679	143	25	å	å	NOUN
bjp-14679	143	26	)	)	PUNCT
bjp-14679	143	27	native	native	ADJ
bjp-14679	143	28	1	1	NUM
bjp-14679	143	29	0.000	0.000	NUM
bjp-14679	143	30	m1(e336d	m1(e336d	NOUN
bjp-14679	143	31	)	)	PUNCT
bjp-14679	143	32	0.015	0.015	NUM
bjp-14679	143	33	m2(a298	m2(a298	NOUN
bjp-14679	143	34	t	t	PROPN
bjp-14679	143	35	)	)	PUNCT
bjp-14679	143	36	0.105	0.105	NUM
bjp-14679	143	37	m3(p201r	m3(p201r	PROPN
bjp-14679	143	38	)	)	PUNCT
bjp-14679	143	39	3.617	3.617	NUM
bjp-14679	143	40	m4(r169h	m4(r169h	NOUN
bjp-14679	143	41	)	)	PUNCT
bjp-14679	143	42	0.028	0.028	NUM
bjp-14679	143	43	b	b	PROPN
bjp-14679	143	44	in	in	ADP
bjp-14679	143	45	di	di	X
bjp-14679	143	46	ng	ng	PROPN
bjp-14679	143	47	fr	fr	PROPN
bjp-14679	143	48	ee	ee	PROPN
bjp-14679	144	1	e	e	PROPN
bjp-14679	144	2	ne	ne	PROPN
bjp-14679	144	3	rg	rg	PROPN
bjp-14679	144	4	y	y	PROPN
bjp-14679	144	5	δg	δg	PROPN
bjp-14679	144	6	(	(	PUNCT
bjp-14679	144	7	k	k	X
bjp-14679	144	8	ca	ca	PROPN
bjp-14679	144	9	l	l	NOUN
bjp-14679	144	10	/	/	SYM
bjp-14679	144	11	m	m	NOUN
bjp-14679	144	12	ol	ol	ADJ
bjp-14679	144	13	)	)	PUNCT
bjp-14679	144	14	-60	-60	PUNCT
bjp-14679	144	15	-50	-50	PUNCT
bjp-14679	144	16	-40	-40	PROPN
bjp-14679	144	17	-30	-30	NUM
bjp-14679	144	18	-20	-20	NUM
bjp-14679	144	19	-10	-10	SYM
bjp-14679	144	20	0	0	NUM
bjp-14679	145	1	native	native	PROPN
bjp-14679	145	2	e336d	e336d	PROPN
bjp-14679	146	1	a298	a298	PROPN
bjp-14679	146	2	t	t	PROPN
bjp-14679	146	3	p201r	p201r	PROPN
bjp-14679	146	4	r169h	r169h	PROPN
bjp-14679	146	5	structures	structure	NOUN
bjp-14679	146	6	of	of	ADP
bjp-14679	146	7	e	e	NOUN
bjp-14679	146	8	-	-	NOUN
bjp-14679	146	9	catherin	catherin	NOUN
bjp-14679	146	10	-52.3	-52.3	NOUN
bjp-14679	146	11	-45.1	-45.1	PUNCT
bjp-14679	146	12	-44.0	-44.0	VERB
bjp-14679	146	13	-43.3	-43.3	DET
bjp-14679	146	14	-30.0	-30.0	NOUN
bjp-14679	146	15	figure	figure	NOUN
bjp-14679	146	16	2	2	NUM
bjp-14679	146	17	:	:	PUNCT
bjp-14679	146	18	estimation	estimation	NOUN
bjp-14679	146	19	of	of	ADP
bjp-14679	146	20	free	free	ADJ
bjp-14679	146	21	energy	energy	NOUN
bjp-14679	146	22	of	of	ADP
bjp-14679	146	23	binding	bind	VERB
bjp-14679	146	24	,	,	PUNCT
bjp-14679	146	25	dg	dg	PROPN
bjp-14679	146	26	,	,	PUNCT
bjp-14679	146	27	(	(	PUNCT
bjp-14679	146	28	kcal	kcal	PROPN
bjp-14679	146	29	/	/	SYM
bjp-14679	146	30	mol	mol	NOUN
bjp-14679	146	31	)	)	PUNCT
bjp-14679	146	32	using	use	VERB
bjp-14679	146	33	firedock	firedock	NOUN
bjp-14679	146	34	12	12	NUM
bjp-14679	146	35	:	:	PUNCT
bjp-14679	146	36	224	224	NUM
bjp-14679	146	37	-	-	SYM
bjp-14679	146	38	32	32	NUM
bjp-14679	146	39	.	.	PUNCT
bjp-14679	147	1	brooks	brooks	PROPN
bjp-14679	147	2	-	-	PUNCT
bjp-14679	147	3	wilson	wilson	PROPN
bjp-14679	147	4	ar	ar	PROPN
bjp-14679	147	5	,	,	PUNCT
bjp-14679	147	6	kaurah	kaurah	PROPN
bjp-14679	147	7	p	p	X
bjp-14679	147	8	,	,	PUNCT
bjp-14679	147	9	suriano	suriano	ADJ
bjp-14679	147	10	g	g	NOUN
bjp-14679	147	11	,	,	PUNCT
bjp-14679	147	12	leach	leach	NOUN
bjp-14679	147	13	s	s	PART
bjp-14679	147	14	,	,	PUNCT
bjp-14679	147	15	senz	senz	PROPN
bjp-14679	147	16	j	j	PROPN
bjp-14679	147	17	,	,	PUNCT
bjp-14679	147	18	grehan	grehan	PROPN
bjp-14679	147	19	n	n	CCONJ
bjp-14679	147	20	,	,	PUNCT
bjp-14679	147	21	butterfield	butterfield	PROPN
bjp-14679	147	22	ysn	ysn	PROPN
bjp-14679	147	23	,	,	PUNCT
bjp-14679	147	24	jeyes	jeyes	PROPN
bjp-14679	147	25	j	j	PROPN
bjp-14679	147	26	,	,	PUNCT
bjp-14679	147	27	schinas	schinas	PROPN
bjp-14679	147	28	j	j	PROPN
bjp-14679	147	29	,	,	PUNCT
bjp-14679	147	30	bacani	bacani	PROPN
bjp-14679	147	31	j	j	PROPN
bjp-14679	147	32	,	,	PUNCT
bjp-14679	147	33	kelsey	kelsey	PROPN
bjp-14679	147	34	m	m	PROPN
bjp-14679	147	35	,	,	PUNCT
bjp-14679	147	36	ferreira	ferreira	PROPN
bjp-14679	147	37	p	p	PROPN
bjp-14679	147	38	,	,	PUNCT
bjp-14679	147	39	macgillivray	macgillivray	PROPN
bjp-14679	147	40	b	b	PROPN
bjp-14679	147	41	,	,	PUNCT
bjp-14679	147	42	macleod	macleod	PROPN
bjp-14679	147	43	p	p	PROPN
bjp-14679	147	44	,	,	PUNCT
bjp-14679	147	45	micek	micek	PROPN
bjp-14679	147	46	m	m	PROPN
bjp-14679	147	47	,	,	PUNCT
bjp-14679	147	48	ford	ford	PROPN
bjp-14679	147	49	j	j	PROPN
bjp-14679	147	50	,	,	PUNCT
bjp-14679	147	51	foulkes	foulkes	PROPN
bjp-14679	147	52	w	w	PROPN
bjp-14679	147	53	,	,	PUNCT
bjp-14679	147	54	australie	australie	PROPN
bjp-14679	147	55	k	k	PROPN
bjp-14679	147	56	,	,	PUNCT
bjp-14679	147	57	greenberg	greenberg	PROPN
bjp-14679	147	58	c	c	PROPN
bjp-14679	147	59	,	,	PUNCT
bjp-14679	147	60	lapointe	lapointe	PROPN
bjp-14679	147	61	m	m	PROPN
bjp-14679	147	62	,	,	PUNCT
bjp-14679	147	63	gilpin	gilpin	NOUN
bjp-14679	147	64	c	c	NOUN
bjp-14679	147	65	,	,	PUNCT
bjp-14679	147	66	nikkel	nikkel	NOUN
bjp-14679	147	67	s	s	PART
bjp-14679	147	68	,	,	PUNCT
bjp-14679	147	69	gilchrist	gilchrist	NOUN
bjp-14679	147	70	d	d	PROPN
bjp-14679	147	71	,	,	PUNCT
bjp-14679	147	72	hughes	hughes	PROPN
bjp-14679	147	73	r	r	PROPN
bjp-14679	147	74	,	,	PUNCT
bjp-14679	147	75	jackson	jackson	PROPN
bjp-14679	147	76	ce	ce	PROPN
bjp-14679	147	77	,	,	PUNCT
bjp-14679	147	78	monaghan	monaghan	PROPN
bjp-14679	147	79	kg	kg	PROPN
bjp-14679	147	80	,	,	PUNCT
bjp-14679	147	81	oliveira	oliveira	PROPN
bjp-14679	147	82	mj	mj	PROPN
bjp-14679	147	83	,	,	PUNCT
bjp-14679	147	84	seruca	seruca	ADJ
bjp-14679	147	85	r	r	NOUN
bjp-14679	147	86	,	,	PUNCT
bjp-14679	147	87	gallinger	gallinger	NOUN
bjp-14679	147	88	s	s	PROPN
bjp-14679	147	89	,	,	PUNCT
bjp-14679	147	90	caldas	caldas	PROPN
bjp-14679	147	91	c	c	PROPN
bjp-14679	147	92	,	,	PUNCT
bjp-14679	147	93	huntsman	huntsman	PROPN
bjp-14679	147	94	d.	d.	PROPN
bjp-14679	147	95	germline	germline	PROPN
bjp-14679	147	96	e	e	PROPN
bjp-14679	147	97	-	-	NOUN
bjp-14679	147	98	cadherin	cadherin	NOUN
bjp-14679	147	99	mutations	mutation	NOUN
bjp-14679	147	100	in	in	ADP
bjp-14679	147	101	hereditary	hereditary	ADJ
bjp-14679	147	102	diffuse	diffuse	NOUN
bjp-14679	147	103	gastric	gastric	ADJ
bjp-14679	147	104	cancer	cancer	NOUN
bjp-14679	147	105	:	:	PUNCT
bjp-14679	147	106	assessment	assessment	NOUN
bjp-14679	147	107	of	of	ADP
bjp-14679	147	108	42	42	NUM
bjp-14679	147	109	new	new	ADJ
bjp-14679	147	110	families	family	NOUN
bjp-14679	147	111	and	and	CCONJ
bjp-14679	147	112	review	review	NOUN
bjp-14679	147	113	of	of	ADP
bjp-14679	147	114	genetic	genetic	ADJ
bjp-14679	147	115	screening	screening	NOUN
bjp-14679	147	116	criteria	criterion	NOUN
bjp-14679	147	117	.	.	PUNCT
bjp-14679	148	1	j	j	PROPN
bjp-14679	148	2	med	med	PROPN
bjp-14679	148	3	genet	genet	PROPN
bjp-14679	148	4	.	.	PUNCT
bjp-14679	149	1	2004	2004	NUM
bjp-14679	149	2	;	;	PUNCT
bjp-14679	149	3	41	41	NUM
bjp-14679	149	4	:	:	PUNCT
bjp-14679	149	5	508	508	NUM
bjp-14679	149	6	-	-	SYM
bjp-14679	149	7	17	17	NUM
bjp-14679	149	8	.	.	PUNCT
bjp-14679	150	1	calabrese	calabrese	ADJ
bjp-14679	150	2	r	r	NOUN
bjp-14679	150	3	,	,	PUNCT
bjp-14679	150	4	capriotti	capriotti	NOUN
bjp-14679	150	5	e	e	NOUN
bjp-14679	150	6	,	,	PUNCT
bjp-14679	150	7	fariselli	fariselli	VERB
bjp-14679	150	8	p	p	PROPN
bjp-14679	150	9	,	,	PUNCT
bjp-14679	150	10	martelli	martelli	PROPN
bjp-14679	150	11	pl	pl	PROPN
bjp-14679	150	12	,	,	PUNCT
bjp-14679	150	13	casadio	casadio	PROPN
bjp-14679	150	14	r.	r.	PROPN
bjp-14679	150	15	functional	functional	ADJ
bjp-14679	150	16	annotations	annotation	NOUN
bjp-14679	150	17	improve	improve	VERB
bjp-14679	150	18	the	the	DET
bjp-14679	150	19	predictive	predictive	ADJ
bjp-14679	150	20	score	score	NOUN
bjp-14679	150	21	of	of	ADP
bjp-14679	150	22	human	human	ADJ
bjp-14679	150	23	disease	disease	NOUN
bjp-14679	150	24	-	-	PUNCT
bjp-14679	150	25	related	relate	VERB
bjp-14679	150	26	mutations	mutation	NOUN
bjp-14679	150	27	in	in	ADP
bjp-14679	150	28	proteins	protein	NOUN
bjp-14679	150	29	.	.	PUNCT
bjp-14679	151	1	human	human	ADJ
bjp-14679	151	2	mutation	mutation	NOUN
bjp-14679	151	3	,	,	PUNCT
bjp-14679	151	4	2009	2009	NUM
bjp-14679	151	5	;	;	PUNCT
bjp-14679	151	6	30	30	NUM
bjp-14679	151	7	:	:	SYM
bjp-14679	151	8	1237	1237	NUM
bjp-14679	151	9	-	-	SYM
bjp-14679	151	10	44	44	NUM
bjp-14679	151	11	.	.	PUNCT
bjp-14679	152	1	capriotti	capriotti	PROPN
bjp-14679	152	2	e	e	PROPN
bjp-14679	152	3	,	,	PUNCT
bjp-14679	152	4	fariselli	fariselli	VERB
bjp-14679	152	5	p	p	NOUN
bjp-14679	152	6	,	,	PUNCT
bjp-14679	152	7	casadio	casadio	PROPN
bjp-14679	152	8	r.	r.	PROPN
bjp-14679	152	9	i	i	PROPN
bjp-14679	152	10	-	-	PUNCT
bjp-14679	152	11	mutant2.0	mutant2.0	PROPN
bjp-14679	152	12	:	:	PUNCT
bjp-14679	152	13	predicting	predict	VERB
bjp-14679	152	14	stability	stability	NOUN
bjp-14679	152	15	changes	change	VERB
bjp-14679	152	16	upon	upon	SCONJ
bjp-14679	152	17	mutation	mutation	NOUN
bjp-14679	152	18	from	from	ADP
bjp-14679	152	19	the	the	DET
bjp-14679	152	20	protein	protein	NOUN
bjp-14679	152	21	sequence	sequence	NOUN
bjp-14679	152	22	or	or	CCONJ
bjp-14679	152	23	structure	structure	NOUN
bjp-14679	152	24	.	.	PUNCT
bjp-14679	153	1	nucleic	nucleic	ADJ
bjp-14679	153	2	acids	acid	NOUN
bjp-14679	153	3	res	re	NOUN
bjp-14679	153	4	.	.	PUNCT
bjp-14679	153	5	2005	2005	NUM
bjp-14679	153	6	;	;	PUNCT
bjp-14679	153	7	33	33	NUM
bjp-14679	153	8	:	:	SYM
bjp-14679	153	9	306	306	NUM
bjp-14679	153	10	-	-	SYM
bjp-14679	153	11	10	10	NUM
bjp-14679	153	12	.	.	PUNCT
bjp-14679	154	1	corso	corso	NOUN
bjp-14679	154	2	g	g	PROPN
bjp-14679	154	3	,	,	PUNCT
bjp-14679	154	4	marrelli	marrelli	NOUN
bjp-14679	154	5	d	d	PROPN
bjp-14679	154	6	,	,	PUNCT
bjp-14679	154	7	pascale	pascale	PROPN
bjp-14679	154	8	v	v	NOUN
bjp-14679	154	9	,	,	PUNCT
bjp-14679	154	10	vindigni	vindigni	NOUN
bjp-14679	154	11	c	c	NOUN
bjp-14679	154	12	,	,	PUNCT
bjp-14679	154	13	roviello	roviello	PROPN
bjp-14679	154	14	f.	f.	PROPN
bjp-14679	154	15	frequency	frequency	PROPN
bjp-14679	154	16	of	of	ADP
bjp-14679	154	17	cdh1	cdh1	PROPN
bjp-14679	154	18	germline	germline	NOUN
bjp-14679	154	19	mutations	mutation	NOUN
bjp-14679	154	20	in	in	ADP
bjp-14679	154	21	gastric	gastric	ADJ
bjp-14679	154	22	carcinoma	carcinoma	NOUN
bjp-14679	154	23	coming	come	VERB
bjp-14679	154	24	from	from	ADP
bjp-14679	154	25	highand	highand	ADJ
bjp-14679	154	26	low	low	ADJ
bjp-14679	154	27	-	-	PUNCT
bjp-14679	154	28	risk	risk	NOUN
bjp-14679	154	29	areas	area	NOUN
bjp-14679	154	30	:	:	PUNCT
bjp-14679	154	31	metanalysis	metanalysis	NOUN
bjp-14679	154	32	and	and	CCONJ
bjp-14679	154	33	systematic	systematic	ADJ
bjp-14679	154	34	review	review	NOUN
bjp-14679	154	35	of	of	ADP
bjp-14679	154	36	the	the	DET
bjp-14679	154	37	literature	literature	NOUN
bjp-14679	154	38	.	.	PUNCT
bjp-14679	155	1	bmc	bmc	PROPN
bjp-14679	155	2	cancer	cancer	NOUN
bjp-14679	155	3	.	.	PUNCT
bjp-14679	156	1	2012	2012	NUM
bjp-14679	156	2	;	;	PUNCT
bjp-14679	156	3	12	12	NUM
bjp-14679	156	4	:	:	SYM
bjp-14679	156	5	8	8	NUM
bjp-14679	156	6	.	.	X
bjp-14679	157	1	graziano	graziano	PROPN
bjp-14679	157	2	f	f	X
bjp-14679	157	3	,	,	PUNCT
bjp-14679	157	4	arduini	arduini	PROPN
bjp-14679	157	5	f	f	PROPN
bjp-14679	157	6	,	,	PUNCT
bjp-14679	157	7	ruzzo	ruzzo	VERB
bjp-14679	157	8	a	a	PRON
bjp-14679	157	9	,	,	PUNCT
bjp-14679	157	10	bearzi	bearzi	NOUN
bjp-14679	157	11	i	i	PRON
bjp-14679	157	12	,	,	PUNCT
bjp-14679	157	13	humar	humar	PROPN
bjp-14679	157	14	b	b	PROPN
bjp-14679	157	15	,	,	PUNCT
bjp-14679	157	16	more	more	ADJ
bjp-14679	157	17	h	h	NOUN
bjp-14679	157	18	,	,	PUNCT
bjp-14679	157	19	silva	silva	PROPN
bjp-14679	157	20	r	r	PROPN
bjp-14679	157	21	,	,	PUNCT
bjp-14679	157	22	muretto	muretto	NOUN
bjp-14679	157	23	p	p	X
bjp-14679	157	24	,	,	PUNCT
bjp-14679	157	25	guilford	guilford	PROPN
bjp-14679	157	26	p	p	PROPN
bjp-14679	157	27	,	,	PUNCT
bjp-14679	157	28	testa	testa	PROPN
bjp-14679	157	29	e	e	NOUN
bjp-14679	157	30	,	,	PUNCT
bjp-14679	157	31	mari	mari	PROPN
bjp-14679	157	32	d	d	PROPN
bjp-14679	157	33	,	,	PUNCT
bjp-14679	157	34	magnani	magnani	PROPN
bjp-14679	157	35	m	m	PROPN
bjp-14679	157	36	,	,	PUNCT
bjp-14679	157	37	cascinu	cascinu	PROPN
bjp-14679	157	38	s.	s.	PROPN
bjp-14679	157	39	prognostic	prognostic	PROPN
bjp-14679	157	40	analysis	analysis	NOUN
bjp-14679	157	41	of	of	ADP
bjp-14679	157	42	e	e	NOUN
bjp-14679	157	43	-	-	NOUN
bjp-14679	157	44	cadherin	cadherin	NOUN
bjp-14679	157	45	gene	gene	NOUN
bjp-14679	157	46	promoter	promoter	NOUN
bjp-14679	157	47	hypermethylation	hypermethylation	NOUN
bjp-14679	157	48	in	in	ADP
bjp-14679	157	49	patients	patient	NOUN
bjp-14679	157	50	with	with	ADP
bjp-14679	157	51	surgically	surgically	ADV
bjp-14679	157	52	resected	resect	VERB
bjp-14679	157	53	,	,	PUNCT
bjp-14679	157	54	node	node	NOUN
bjp-14679	157	55	-	-	PUNCT
bjp-14679	157	56	positive	positive	ADJ
bjp-14679	157	57	,	,	PUNCT
bjp-14679	157	58	diffuse	diffuse	ADJ
bjp-14679	157	59	gastric	gastric	ADJ
bjp-14679	157	60	cancer	cancer	NOUN
bjp-14679	157	61	.	.	PUNCT
bjp-14679	158	1	clin	clin	PROPN
bjp-14679	158	2	cancer	cancer	NOUN
bjp-14679	158	3	res	re	NOUN
bjp-14679	158	4	.	.	PUNCT
bjp-14679	158	5	2004	2004	NUM
bjp-14679	158	6	;	;	PUNCT
bjp-14679	158	7	10	10	NUM
bjp-14679	158	8	:	:	SYM
bjp-14679	158	9	2784	2784	NUM
bjp-14679	158	10	-	-	SYM
bjp-14679	158	11	89	89	NUM
bjp-14679	158	12	.	.	PUNCT
bjp-14679	159	1	heindl	heindl	PROPN
bjp-14679	159	2	s	s	PROPN
bjp-14679	159	3	,	,	PUNCT
bjp-14679	159	4	eggenstein	eggenstein	X
bjp-14679	159	5	e	e	NOUN
bjp-14679	159	6	,	,	PUNCT
bjp-14679	159	7	keller	keller	PROPN
bjp-14679	159	8	s	s	PROPN
bjp-14679	159	9	,	,	PUNCT
bjp-14679	159	10	kneissl	kneissl	PROPN
bjp-14679	159	11	j	j	PROPN
bjp-14679	159	12	,	,	PUNCT
bjp-14679	159	13	keller	keller	PROPN
bjp-14679	159	14	g	g	PROPN
bjp-14679	159	15	,	,	PUNCT
bjp-14679	159	16	mutze	mutze	PROPN
bjp-14679	159	17	k	k	PROPN
bjp-14679	159	18	,	,	PUNCT
bjp-14679	159	19	rauser	rauser	NOUN
bjp-14679	159	20	s	s	PART
bjp-14679	159	21	,	,	PUNCT
bjp-14679	159	22	gasteiger	gasteiger	NOUN
bjp-14679	159	23	g	g	NOUN
bjp-14679	159	24	,	,	PUNCT
bjp-14679	159	25	drexler	drexler	PROPN
bjp-14679	159	26	i	i	PROPN
bjp-14679	159	27	,	,	PUNCT
bjp-14679	159	28	hapfelmeier	hapfelmeier	NOUN
bjp-14679	159	29	a	a	PRON
bjp-14679	159	30	,	,	PUNCT
bjp-14679	159	31	höfler	höfler	NOUN
bjp-14679	159	32	h	h	NOUN
bjp-14679	159	33	,	,	PUNCT
bjp-14679	159	34	luber	luber	PROPN
bjp-14679	159	35	b.	b.	NOUN
bjp-14679	159	36	relevance	relevance	NOUN
bjp-14679	159	37	of	of	ADP
bjp-14679	159	38	met	meet	VERB
bjp-14679	159	39	activation	activation	NOUN
bjp-14679	159	40	and	and	CCONJ
bjp-14679	159	41	genetic	genetic	ADJ
bjp-14679	159	42	alterations	alteration	NOUN
bjp-14679	159	43	of	of	ADP
bjp-14679	159	44	kras	kras	PROPN
bjp-14679	159	45	and	and	CCONJ
bjp-14679	159	46	e	e	NOUN
bjp-14679	159	47	-	-	NOUN
bjp-14679	159	48	cadherin	cadherin	NOUN
bjp-14679	159	49	for	for	ADP
bjp-14679	159	50	cetuximab	cetuximab	NOUN
bjp-14679	159	51	sensitivity	sensitivity	NOUN
bjp-14679	159	52	of	of	ADP
bjp-14679	159	53	gastric	gastric	ADJ
bjp-14679	159	54	cancer	cancer	NOUN
bjp-14679	159	55	cell	cell	NOUN
bjp-14679	159	56	lines	line	NOUN
bjp-14679	159	57	.	.	PUNCT
bjp-14679	160	1	j	j	PROPN
bjp-14679	160	2	cancer	cancer	NOUN
bjp-14679	160	3	res	re	VERB
bjp-14679	160	4	clin	clin	PROPN
bjp-14679	160	5	oncol	oncol	PROPN
bjp-14679	160	6	.	.	PUNCT
bjp-14679	161	1	2012	2012	NUM
bjp-14679	161	2	;	;	PUNCT
bjp-14679	161	3	138	138	NUM
bjp-14679	161	4	:	:	PUNCT
bjp-14679	161	5	843	843	NUM
bjp-14679	161	6	-	-	SYM
bjp-14679	161	7	58	58	NUM
bjp-14679	161	8	.	.	PUNCT
bjp-14679	162	1	kaurah	kaurah	PROPN
bjp-14679	162	2	p	p	X
bjp-14679	162	3	,	,	PUNCT
bjp-14679	162	4	macmillan	macmillan	PROPN
bjp-14679	162	5	a	a	PROPN
bjp-14679	162	6	,	,	PUNCT
bjp-14679	162	7	boyd	boyd	PROPN
bjp-14679	162	8	n	n	CCONJ
bjp-14679	162	9	,	,	PUNCT
bjp-14679	162	10	senz	senz	PROPN
bjp-14679	162	11	j	j	PROPN
bjp-14679	162	12	,	,	PUNCT
bjp-14679	162	13	de	de	PROPN
bjp-14679	162	14	luca	luca	PROPN
bjp-14679	162	15	a	a	DET
bjp-14679	162	16	,	,	PUNCT
bjp-14679	162	17	chun	chun	PROPN
bjp-14679	162	18	n	n	CCONJ
bjp-14679	162	19	,	,	PUNCT
bjp-14679	162	20	suriano	suriano	ADJ
bjp-14679	162	21	g	g	PROPN
bjp-14679	162	22	,	,	PUNCT
bjp-14679	162	23	zaor	zaor	PROPN
bjp-14679	162	24	s	s	PART
bjp-14679	162	25	,	,	PUNCT
bjp-14679	162	26	van	van	PROPN
bjp-14679	162	27	manen	manen	PROPN
bjp-14679	162	28	l	l	PROPN
bjp-14679	162	29	,	,	PUNCT
bjp-14679	162	30	gilpin	gilpin	NOUN
bjp-14679	162	31	c	c	NOUN
bjp-14679	162	32	,	,	PUNCT
bjp-14679	162	33	nikkel	nikkel	NOUN
bjp-14679	162	34	s	s	PROPN
bjp-14679	162	35	,	,	PUNCT
bjp-14679	162	36	connolly	connolly	PROPN
bjp-14679	162	37	-	-	PUNCT
bjp-14679	162	38	wilson	wilson	PROPN
bjp-14679	162	39	m	m	PROPN
bjp-14679	162	40	,	,	PUNCT
bjp-14679	162	41	weissman	weissman	PROPN
bjp-14679	162	42	s	s	PROPN
bjp-14679	162	43	,	,	PUNCT
bjp-14679	162	44	rubinstein	rubinstein	PROPN
bjp-14679	162	45	ws	ws	PROPN
bjp-14679	162	46	,	,	PUNCT
bjp-14679	162	47	sebold	sebold	PROPN
bjp-14679	162	48	c	c	PROPN
bjp-14679	162	49	,	,	PUNCT
bjp-14679	162	50	greenstein	greenstein	PROPN
bjp-14679	162	51	r	r	PROPN
bjp-14679	162	52	,	,	PUNCT
bjp-14679	162	53	stroop	stroop	PROPN
bjp-14679	162	54	j	j	PROPN
bjp-14679	162	55	,	,	PUNCT
bjp-14679	162	56	yim	yim	PROPN
bjp-14679	162	57	d	d	PROPN
bjp-14679	162	58	,	,	PUNCT
bjp-14679	162	59	panzini	panzini	ADJ
bjp-14679	162	60	b	b	PROPN
bjp-14679	162	61	,	,	PUNCT
bjp-14679	162	62	mckinnon	mckinnon	PROPN
bjp-14679	162	63	w	w	PROPN
bjp-14679	162	64	,	,	PUNCT
bjp-14679	162	65	greenblatt	greenblatt	PROPN
bjp-14679	162	66	m	m	PROPN
bjp-14679	162	67	,	,	PUNCT
bjp-14679	162	68	wirtzfeld	wirtzfeld	VERB
bjp-14679	162	69	d	d	PROPN
bjp-14679	162	70	,	,	PUNCT
bjp-14679	162	71	fontaine	fontaine	PROPN
bjp-14679	162	72	d	d	PROPN
bjp-14679	162	73	,	,	PUNCT
bjp-14679	162	74	coit	coit	PROPN
bjp-14679	163	1	d	d	NOUN
bjp-14679	163	2	,	,	PUNCT
bjp-14679	163	3	yoon	yoon	PROPN
bjp-14679	163	4	s	s	PROPN
bjp-14679	163	5	,	,	PUNCT
bjp-14679	163	6	chung	chung	PROPN
bjp-14679	163	7	d	d	PROPN
bjp-14679	163	8	,	,	PUNCT
bjp-14679	163	9	lauwers	lauwer	VERB
bjp-14679	163	10	g	g	NOUN
bjp-14679	163	11	,	,	PUNCT
bjp-14679	163	12	pizzuti	pizzuti	VERB
bjp-14679	163	13	a	a	DET
bjp-14679	163	14	,	,	PUNCT
bjp-14679	163	15	vaccaro	vaccaro	PROPN
bjp-14679	163	16	c	c	NOUN
bjp-14679	163	17	,	,	PUNCT
bjp-14679	163	18	redal	redal	ADV
bjp-14679	163	19	ma	ma	PROPN
bjp-14679	163	20	,	,	PUNCT
bjp-14679	163	21	oliveira	oliveira	PROPN
bjp-14679	163	22	c	c	PROPN
bjp-14679	163	23	,	,	PUNCT
bjp-14679	163	24	tischkowitz	tischkowitz	NOUN
bjp-14679	163	25	m	m	PROPN
bjp-14679	163	26	,	,	PUNCT
bjp-14679	163	27	olschwang	olschwang	PROPN
bjp-14679	163	28	s	s	PROPN
bjp-14679	163	29	,	,	PUNCT
bjp-14679	163	30	gallinger	gallinger	NOUN
bjp-14679	163	31	s	s	PROPN
bjp-14679	163	32	,	,	PUNCT
bjp-14679	163	33	lynch	lynch	PROPN
bjp-14679	163	34	h	h	PROPN
bjp-14679	163	35	,	,	PUNCT
bjp-14679	163	36	green	green	PROPN
bjp-14679	163	37	j	j	PROPN
bjp-14679	163	38	,	,	PUNCT
bjp-14679	163	39	ford	ford	PROPN
bjp-14679	163	40	j	j	PROPN
bjp-14679	163	41	,	,	PUNCT
bjp-14679	163	42	pharoah	pharoah	PROPN
bjp-14679	163	43	p	p	PROPN
bjp-14679	163	44	,	,	PUNCT
bjp-14679	163	45	fernandez	fernandez	PROPN
bjp-14679	163	46	b	b	PROPN
bjp-14679	163	47	,	,	PUNCT
bjp-14679	163	48	huntsman	huntsman	PROPN
bjp-14679	163	49	d.	d.	PROPN
bjp-14679	163	50	founder	founder	NOUN
bjp-14679	163	51	and	and	CCONJ
bjp-14679	163	52	recurrent	recurrent	ADJ
bjp-14679	163	53	cdh1	cdh1	NOUN
bjp-14679	163	54	mutations	mutation	NOUN
bjp-14679	163	55	in	in	ADP
bjp-14679	163	56	families	family	NOUN
bjp-14679	163	57	with	with	ADP
bjp-14679	163	58	hereditary	hereditary	ADJ
bjp-14679	163	59	diffuse	diffuse	ADJ
bjp-14679	163	60	gastric	gastric	ADJ
bjp-14679	163	61	cancer	cancer	NOUN
bjp-14679	163	62	.	.	PUNCT
bjp-14679	164	1	j	j	PROPN
bjp-14679	164	2	am	be	AUX
bjp-14679	164	3	med	med	ADJ
bjp-14679	164	4	assoc	assoc	PROPN
bjp-14679	164	5	.	.	PUNCT
bjp-14679	165	1	2007	2007	NUM
bjp-14679	165	2	;	;	PUNCT
bjp-14679	165	3	297	297	NUM
bjp-14679	165	4	:	:	SYM
bjp-14679	165	5	2360	2360	NUM
bjp-14679	165	6	-	-	SYM
bjp-14679	165	7	72	72	NUM
bjp-14679	165	8	.	.	PUNCT
bjp-14679	166	1	keller	keller	PROPN
bjp-14679	166	2	g	g	PROPN
bjp-14679	166	3	,	,	PUNCT
bjp-14679	166	4	vogelsang	vogelsang	PROPN
bjp-14679	166	5	h	h	PROPN
bjp-14679	166	6	,	,	PUNCT
bjp-14679	166	7	becker	becker	PROPN
bjp-14679	167	1	i	i	PRON
bjp-14679	167	2	,	,	PUNCT
bjp-14679	167	3	hutter	hutter	PROPN
bjp-14679	167	4	j	j	PROPN
bjp-14679	167	5	,	,	PUNCT
bjp-14679	167	6	ott	ott	PROPN
bjp-14679	167	7	k	k	PROPN
bjp-14679	167	8	,	,	PUNCT
bjp-14679	167	9	candidus	candidus	PROPN
bjp-14679	167	10	s	s	PART
bjp-14679	167	11	,	,	PUNCT
bjp-14679	167	12	grundei	grundei	PROPN
bjp-14679	167	13	t	t	PROPN
bjp-14679	167	14	,	,	PUNCT
bjp-14679	167	15	becker	becker	PROPN
bjp-14679	167	16	kf	kf	PROPN
bjp-14679	167	17	,	,	PUNCT
bjp-14679	167	18	mueller	mueller	PROPN
bjp-14679	167	19	j	j	PROPN
bjp-14679	167	20	,	,	PUNCT
bjp-14679	167	21	siewert	siewert	PROPN
bjp-14679	167	22	jr	jr	PROPN
bjp-14679	167	23	,	,	PUNCT
bjp-14679	167	24	höfler	höfler	NOUN
bjp-14679	167	25	h.	h.	NOUN
bjp-14679	167	26	diffuse	diffuse	PROPN
bjp-14679	167	27	type	type	NOUN
bjp-14679	167	28	gastric	gastric	ADJ
bjp-14679	167	29	and	and	CCONJ
bjp-14679	167	30	lobular	lobular	ADJ
bjp-14679	167	31	breast	breast	NOUN
bjp-14679	167	32	carcinoma	carcinoma	NOUN
bjp-14679	167	33	in	in	ADP
bjp-14679	167	34	a	a	DET
bjp-14679	167	35	familial	familial	ADJ
bjp-14679	167	36	gastric	gastric	ADJ
bjp-14679	167	37	cancer	cancer	NOUN
bjp-14679	167	38	patient	patient	NOUN
bjp-14679	167	39	with	with	ADP
bjp-14679	167	40	an	an	DET
bjp-14679	167	41	e	e	NOUN
bjp-14679	167	42	-	-	NOUN
bjp-14679	167	43	cadherin	cadherin	NOUN
bjp-14679	167	44	germline	germline	NOUN
bjp-14679	167	45	mutation	mutation	NOUN
bjp-14679	167	46	.	.	PUNCT
bjp-14679	168	1	am	be	AUX
bjp-14679	168	2	j	j	PROPN
bjp-14679	168	3	pathol	pathol	NOUN
bjp-14679	168	4	.	.	PUNCT
bjp-14679	169	1	1999	1999	NUM
bjp-14679	169	2	;	;	PUNCT
bjp-14679	169	3	155	155	NUM
bjp-14679	169	4	:	:	SYM
bjp-14679	169	5	337	337	NUM
bjp-14679	169	6	-	-	SYM
bjp-14679	169	7	42	42	NUM
bjp-14679	169	8	.	.	PUNCT
bjp-14679	170	1	kim	kim	PROPN
bjp-14679	170	2	hc	hc	PROPN
bjp-14679	170	3	,	,	PUNCT
bjp-14679	170	4	wheeler	wheeler	PROPN
bjp-14679	170	5	jmd	jmd	PROPN
bjp-14679	170	6	,	,	PUNCT
bjp-14679	170	7	kim	kim	PROPN
bjp-14679	170	8	jc	jc	PROPN
bjp-14679	170	9	,	,	PUNCT
bjp-14679	170	10	ilyas	ilyas	PROPN
bjp-14679	170	11	m	m	PROPN
bjp-14679	170	12	,	,	PUNCT
bjp-14679	170	13	beck	beck	PROPN
bjp-14679	170	14	ne	ne	PROPN
bjp-14679	170	15	,	,	PUNCT
bjp-14679	170	16	kim	kim	PROPN
bjp-14679	170	17	bs	bs	PROPN
bjp-14679	170	18	,	,	PUNCT
bjp-14679	170	19	park	park	NOUN
bjp-14679	170	20	kc	kc	PROPN
bjp-14679	170	21	,	,	PUNCT
bjp-14679	170	22	bodmer	bodmer	PROPN
bjp-14679	170	23	wf	wf	PROPN
bjp-14679	170	24	.	.	PUNCT
bjp-14679	171	1	the	the	DET
bjp-14679	171	2	e	e	NOUN
bjp-14679	171	3	-	-	NOUN
bjp-14679	171	4	cadherin	cadherin	NOUN
bjp-14679	171	5	gene	gene	NOUN
bjp-14679	171	6	(	(	PUNCT
bjp-14679	171	7	cdh1	cdh1	NOUN
bjp-14679	171	8	)	)	PUNCT
bjp-14679	171	9	variants	variant	NOUN
bjp-14679	171	10	t340a	t340a	PROPN
bjp-14679	171	11	and	and	CCONJ
bjp-14679	171	12	l599v	l599v	PROPN
bjp-14679	171	13	in	in	ADP
bjp-14679	171	14	gastric	gastric	ADJ
bjp-14679	171	15	and	and	CCONJ
bjp-14679	171	16	colorectal	colorectal	ADJ
bjp-14679	171	17	cancer	cancer	NOUN
bjp-14679	171	18	patients	patient	NOUN
bjp-14679	171	19	in	in	ADP
bjp-14679	171	20	korea	korea	PROPN
bjp-14679	171	21	.	.	PUNCT
bjp-14679	172	1	gut	gut	PROPN
bjp-14679	172	2	2000	2000	NUM
bjp-14679	172	3	;	;	PUNCT
bjp-14679	172	4	47	47	NUM
bjp-14679	172	5	:	:	PUNCT
bjp-14679	172	6	262	262	NUM
bjp-14679	172	7	-	-	SYM
bjp-14679	172	8	67	67	NUM
bjp-14679	172	9	.	.	PUNCT
bjp-14679	173	1	lordick	lordick	PROPN
bjp-14679	173	2	f	f	PROPN
bjp-14679	173	3	,	,	PUNCT
bjp-14679	173	4	luber	luber	PROPN
bjp-14679	173	5	b	b	NUM
bjp-14679	173	6	,	,	PUNCT
bjp-14679	173	7	lorenzen	lorenzen	PROPN
bjp-14679	173	8	s	s	PROPN
bjp-14679	173	9	,	,	PUNCT
bjp-14679	173	10	hegewisch	hegewisch	PROPN
bjp-14679	173	11	-	-	PUNCT
bjp-14679	173	12	becker	becker	PROPN
bjp-14679	173	13	s	s	PART
bjp-14679	173	14	,	,	PUNCT
bjp-14679	173	15	folprecht	folprecht	VERB
bjp-14679	173	16	g	g	PROPN
bjp-14679	173	17	,	,	PUNCT
bjp-14679	173	18	wöll	wöll	PROPN
bjp-14679	173	19	e	e	PROPN
bjp-14679	173	20	,	,	PUNCT
bjp-14679	173	21	decker	decker	PROPN
bjp-14679	173	22	t	t	PROPN
bjp-14679	173	23	,	,	PUNCT
bjp-14679	173	24	endlicher	endlicher	ADJ
bjp-14679	173	25	e	e	NOUN
bjp-14679	173	26	,	,	PUNCT
bjp-14679	173	27	röthling	röthle	VERB
bjp-14679	173	28	n	n	CCONJ
bjp-14679	173	29	,	,	PUNCT
bjp-14679	173	30	schuster	schuster	PROPN
bjp-14679	173	31	t	t	PROPN
bjp-14679	173	32	,	,	PUNCT
bjp-14679	173	33	keller	keller	PROPN
bjp-14679	173	34	g	g	PROPN
bjp-14679	173	35	,	,	PUNCT
bjp-14679	173	36	fend	fend	VERB
bjp-14679	173	37	f	f	PROPN
bjp-14679	173	38	and	and	CCONJ
bjp-14679	173	39	peschel	peschel	PROPN
bjp-14679	173	40	c.	c.	PROPN
bjp-14679	173	41	cetuximab	cetuximab	PROPN
bjp-14679	173	42	plus	plus	CCONJ
bjp-14679	173	43	oxaliplatin/	oxaliplatin/	NUM
bjp-14679	173	44	leucovorin/5	leucovorin/5	NOUN
bjp-14679	173	45	-	-	PUNCT
bjp-14679	173	46	fluorouracil	fluorouracil	NOUN
bjp-14679	173	47	in	in	ADP
bjp-14679	173	48	first	first	ADJ
bjp-14679	173	49	-	-	PUNCT
bjp-14679	173	50	line	line	NOUN
bjp-14679	173	51	metastatic	metastatic	ADJ
bjp-14679	173	52	gastric	gastric	ADJ
bjp-14679	173	53	cancer	cancer	NOUN
bjp-14679	173	54	:	:	PUNCT
bjp-14679	173	55	a	a	DET
bjp-14679	173	56	phase	phase	NOUN
bjp-14679	173	57	ii	ii	NOUN
bjp-14679	173	58	study	study	NOUN
bjp-14679	173	59	of	of	ADP
bjp-14679	173	60	the	the	DET
bjp-14679	173	61	arbeitsgemeinschaft	arbeitsgemeinschaft	NOUN
bjp-14679	173	62	internistische	internistische	PROPN
bjp-14679	173	63	onkologie	onkologie	X
bjp-14679	173	64	(	(	PUNCT
bjp-14679	173	65	aio	aio	NOUN
bjp-14679	173	66	)	)	PUNCT
bjp-14679	173	67	.	.	PUNCT
bjp-14679	174	1	brit	brit	PROPN
bjp-14679	174	2	j	j	PROPN
bjp-14679	174	3	cancer	cancer	NOUN
bjp-14679	174	4	.	.	PUNCT
bjp-14679	175	1	2010	2010	NUM
bjp-14679	175	2	;	;	PUNCT
bjp-14679	175	3	102	102	NUM
bjp-14679	175	4	:	:	SYM
bjp-14679	175	5	50005	50005	NUM
bjp-14679	175	6	.	.	PUNCT
bjp-14679	176	1	mashiach	mashiach	PROPN
bjp-14679	176	2	e	e	NOUN
bjp-14679	176	3	,	,	PUNCT
bjp-14679	176	4	schneidman	schneidman	NOUN
bjp-14679	176	5	-	-	PUNCT
bjp-14679	176	6	duhovny	duhovny	NOUN
bjp-14679	176	7	d	d	NOUN
bjp-14679	176	8	,	,	PUNCT
bjp-14679	176	9	andrusier	andrusier	PROPN
bjp-14679	176	10	n	n	CCONJ
bjp-14679	176	11	,	,	PUNCT
bjp-14679	176	12	nussinov	nussinov	VERB
bjp-14679	176	13	r	r	NOUN
bjp-14679	176	14	,	,	PUNCT
bjp-14679	176	15	wolfson	wolfson	PROPN
bjp-14679	176	16	h	h	PROPN
bjp-14679	176	17	firedock	firedock	NOUN
bjp-14679	176	18	:	:	PUNCT
bjp-14679	176	19	a	a	DET
bjp-14679	176	20	web	web	NOUN
bjp-14679	176	21	server	server	NOUN
bjp-14679	176	22	for	for	ADP
bjp-14679	176	23	fast	fast	ADJ
bjp-14679	176	24	interaction	interaction	NOUN
bjp-14679	176	25	refinement	refinement	NOUN
bjp-14679	176	26	in	in	ADP
bjp-14679	176	27	molecular	molecular	ADJ
bjp-14679	176	28	docking	docking	NOUN
bjp-14679	176	29	.	.	PUNCT
bjp-14679	177	1	nucleic	nucleic	ADJ
bjp-14679	177	2	acids	acid	NOUN
bjp-14679	177	3	res	re	NOUN
bjp-14679	177	4	.	.	PUNCT
bjp-14679	177	5	2008	2008	NUM
bjp-14679	177	6	;	;	PUNCT
bjp-14679	177	7	36	36	NUM
bjp-14679	177	8	:	:	PUNCT
bjp-14679	177	9	w229	w229	PROPN
bjp-14679	177	10	-	-	SYM
bjp-14679	177	11	32	32	NUM
bjp-14679	177	12	.	.	PUNCT
bjp-14679	178	1	more	more	ADJ
bjp-14679	178	2	h	h	NOUN
bjp-14679	178	3	,	,	PUNCT
bjp-14679	178	4	humar	humar	PROPN
bjp-14679	178	5	b	b	PROPN
bjp-14679	178	6	,	,	PUNCT
bjp-14679	178	7	weber	weber	PROPN
bjp-14679	178	8	w	w	PROPN
bjp-14679	178	9	,	,	PUNCT
bjp-14679	178	10	ward	ward	NOUN
bjp-14679	178	11	r	r	NOUN
bjp-14679	178	12	,	,	PUNCT
bjp-14679	178	13	christian	christian	PROPN
bjp-14679	178	14	a	a	X
bjp-14679	178	15	,	,	PUNCT
bjp-14679	178	16	lintott	lintott	PROPN
bjp-14679	178	17	c	c	PROPN
bjp-14679	178	18	,	,	PUNCT
bjp-14679	178	19	graziano	graziano	PROPN
bjp-14679	178	20	f	f	AUX
bjp-14679	178	21	,	,	PUNCT
bjp-14679	178	22	ruzzo	ruzzo	PROPN
bjp-14679	178	23	am	be	AUX
bjp-14679	178	24	,	,	PUNCT
bjp-14679	178	25	acosta	acosta	PROPN
bjp-14679	178	26	e	e	PROPN
bjp-14679	178	27	,	,	PUNCT
bjp-14679	178	28	boman	boman	PROPN
bjp-14679	178	29	b	b	PROPN
bjp-14679	178	30	,	,	PUNCT
bjp-14679	178	31	harlan	harlan	PROPN
bjp-14679	178	32	m	m	PROPN
bjp-14679	178	33	,	,	PUNCT
bjp-14679	178	34	ferreira	ferreira	PROPN
bjp-14679	178	35	p	p	PROPN
bjp-14679	178	36	,	,	PUNCT
bjp-14679	178	37	seruca	seruca	ADJ
bjp-14679	178	38	r	r	NOUN
bjp-14679	178	39	,	,	PUNCT
bjp-14679	178	40	suriano	suriano	ADJ
bjp-14679	178	41	g	g	NOUN
bjp-14679	178	42	,	,	PUNCT
bjp-14679	178	43	guilford	guilford	PROPN
bjp-14679	178	44	p.	p.	PROPN
bjp-14679	178	45	identification	identification	NOUN
bjp-14679	178	46	of	of	ADP
bjp-14679	178	47	seven	seven	NUM
bjp-14679	178	48	novel	novel	NOUN
bjp-14679	178	49	germline	germline	NOUN
bjp-14679	178	50	mutations	mutation	NOUN
bjp-14679	178	51	in	in	ADP
bjp-14679	178	52	the	the	DET
bjp-14679	178	53	human	human	ADJ
bjp-14679	178	54	e	e	NOUN
bjp-14679	178	55	-	-	NOUN
bjp-14679	178	56	cadherin	cadherin	NOUN
bjp-14679	178	57	(	(	PUNCT
bjp-14679	178	58	cdh1	cdh1	NOUN
bjp-14679	178	59	)	)	PUNCT
bjp-14679	178	60	gene	gene	NOUN
bjp-14679	178	61	.	.	PUNCT
bjp-14679	179	1	human	human	ADJ
bjp-14679	179	2	mutation	mutation	NOUN
bjp-14679	179	3	.	.	PUNCT
bjp-14679	180	1	2007	2007	NUM
bjp-14679	180	2	;	;	PUNCT
bjp-14679	180	3	28	28	NUM
bjp-14679	180	4	:	:	SYM
bjp-14679	180	5	203	203	NUM
bjp-14679	180	6	.	.	PUNCT
bjp-14679	181	1	ng	ng	PROPN
bjp-14679	181	2	pc	pc	PROPN
bjp-14679	181	3	,	,	PUNCT
bjp-14679	181	4	henikoff	henikoff	NOUN
bjp-14679	181	5	s.	s.	PROPN
bjp-14679	181	6	sift	sift	PROPN
bjp-14679	181	7	:	:	PUNCT
bjp-14679	181	8	predicting	predict	VERB
bjp-14679	181	9	amino	amino	NOUN
bjp-14679	181	10	acid	acid	NOUN
bjp-14679	181	11	changes	change	NOUN
bjp-14679	181	12	that	that	PRON
bjp-14679	181	13	affect	affect	VERB
bjp-14679	181	14	protein	protein	NOUN
bjp-14679	181	15	function	function	NOUN
bjp-14679	181	16	.	.	PUNCT
bjp-14679	182	1	nucleic	nucleic	ADJ
bjp-14679	182	2	acids	acid	NOUN
bjp-14679	182	3	res	re	NOUN
bjp-14679	182	4	.	.	PUNCT
bjp-14679	182	5	2003	2003	NUM
bjp-14679	182	6	;	;	PUNCT
bjp-14679	182	7	31	31	NUM
bjp-14679	182	8	:	:	SYM
bjp-14679	182	9	3812	3812	NUM
bjp-14679	182	10	-	-	SYM
bjp-14679	182	11	14	14	NUM
bjp-14679	182	12	.	.	PUNCT
bjp-14679	182	13	nishiyama	nishiyama	PROPN
bjp-14679	182	14	m	m	PROPN
bjp-14679	182	15	,	,	PUNCT
bjp-14679	182	16	wada	wada	PROPN
bjp-14679	182	17	s.	s.	PROPN
bjp-14679	182	18	docetaxel	docetaxel	PROPN
bjp-14679	182	19	:	:	PUNCT
bjp-14679	182	20	its	its	PRON
bjp-14679	182	21	role	role	NOUN
bjp-14679	182	22	in	in	ADP
bjp-14679	182	23	current	current	ADJ
bjp-14679	182	24	and	and	CCONJ
bjp-14679	182	25	future	future	ADJ
bjp-14679	182	26	treatments	treatment	NOUN
bjp-14679	182	27	for	for	ADP
bjp-14679	182	28	advanced	advanced	ADJ
bjp-14679	182	29	gastric	gastric	ADJ
bjp-14679	182	30	cancer	cancer	NOUN
bjp-14679	182	31	.	.	PUNCT
bjp-14679	183	1	gastric	gastric	ADJ
bjp-14679	183	2	cancer	cancer	NOUN
bjp-14679	183	3	.	.	PUNCT
bjp-14679	184	1	2009	2009	NUM
bjp-14679	184	2	;	;	PUNCT
bjp-14679	184	3	12	12	NUM
bjp-14679	184	4	:	:	SYM
bjp-14679	184	5	132	132	NUM
bjp-14679	184	6	-	-	SYM
bjp-14679	184	7	41	41	NUM
bjp-14679	184	8	.	.	PUNCT
bjp-14679	185	1	oliveira	oliveira	PROPN
bjp-14679	185	2	c	c	PROPN
bjp-14679	185	3	,	,	PUNCT
bjp-14679	185	4	suriano	suriano	ADJ
bjp-14679	185	5	g	g	PROPN
bjp-14679	185	6	,	,	PUNCT
bjp-14679	185	7	ferreira	ferreira	PROPN
bjp-14679	185	8	p	p	PROPN
bjp-14679	185	9	,	,	PUNCT
bjp-14679	185	10	canedo	canedo	PROPN
bjp-14679	185	11	p	p	NOUN
bjp-14679	185	12	,	,	PUNCT
bjp-14679	185	13	kaurah	kaurah	PROPN
bjp-14679	185	14	p	p	X
bjp-14679	185	15	,	,	PUNCT
bjp-14679	185	16	mateus	mateus	PROPN
bjp-14679	185	17	r	r	PROPN
bjp-14679	185	18	,	,	PUNCT
bjp-14679	185	19	ferreira	ferreira	PROPN
bjp-14679	185	20	a	a	PROPN
bjp-14679	185	21	,	,	PUNCT
bjp-14679	185	22	antónio	antónio	PROPN
bjp-14679	185	23	c.	c.	PROPN
bjp-14679	185	24	ferreira	ferreira	PROPN
bjp-14679	185	25	,	,	PUNCT
bjp-14679	185	26	oliveira	oliveira	PROPN
bjp-14679	185	27	mj	mj	PROPN
bjp-14679	185	28	,	,	PUNCT
bjp-14679	185	29	figueiredo	figueiredo	PROPN
bjp-14679	185	30	c	c	PROPN
bjp-14679	185	31	,	,	PUNCT
bjp-14679	185	32	carneiro	carneiro	PROPN
bjp-14679	185	33	f	f	PROPN
bjp-14679	185	34	,	,	PUNCT
bjp-14679	185	35	keller	keller	PROPN
bjp-14679	185	36	g	g	PROPN
bjp-14679	185	37	,	,	PUNCT
bjp-14679	185	38	huntsman	huntsman	PROPN
bjp-14679	185	39	d	d	PROPN
bjp-14679	185	40	,	,	PUNCT
bjp-14679	185	41	machado	machado	PROPN
bjp-14679	185	42	jc	jc	PROPN
bjp-14679	185	43	,	,	PUNCT
bjp-14679	185	44	seruca	seruca	PROPN
bjp-14679	185	45	r.	r.	PROPN
bjp-14679	185	46	genetic	genetic	ADJ
bjp-14679	185	47	screening	screening	NOUN
bjp-14679	185	48	for	for	ADP
bjp-14679	185	49	familial	familial	ADJ
bjp-14679	185	50	gastric	gastric	ADJ
bjp-14679	185	51	cancer	cancer	NOUN
bjp-14679	185	52	.	.	PUNCT
bjp-14679	186	1	hereditary	hereditary	ADJ
bjp-14679	186	2	cancer	cancer	NOUN
bjp-14679	186	3	clin	clin	PROPN
bjp-14679	186	4	practice	practice	NOUN
bjp-14679	186	5	.	.	PUNCT
bjp-14679	187	1	2004	2004	NUM
bjp-14679	187	2	;	;	PUNCT
bjp-14679	187	3	2	2	NUM
bjp-14679	187	4	:	:	SYM
bjp-14679	187	5	51	51	NUM
bjp-14679	187	6	-	-	SYM
bjp-14679	187	7	64	64	NUM
bjp-14679	187	8	.	.	PUNCT
bjp-14679	188	1	pećina	pećina	ADJ
bjp-14679	188	2	-	-	PUNCT
bjp-14679	188	3	šlaus	šlaus	PROPN
bjp-14679	188	4	n.	n.	PROPN
bjp-14679	188	5	tumor	tumor	PROPN
bjp-14679	188	6	suppressor	suppressor	NOUN
bjp-14679	188	7	gene	gene	NOUN
bjp-14679	188	8	e	e	NOUN
bjp-14679	188	9	-	-	NOUN
bjp-14679	188	10	cadherin	cadherin	NOUN
bjp-14679	188	11	and	and	CCONJ
bjp-14679	188	12	its	its	PRON
bjp-14679	188	13	role	role	NOUN
bjp-14679	188	14	in	in	ADP
bjp-14679	188	15	normal	normal	ADJ
bjp-14679	188	16	and	and	CCONJ
bjp-14679	188	17	malignant	malignant	ADJ
bjp-14679	188	18	cells	cell	NOUN
bjp-14679	188	19	.	.	PUNCT
bjp-14679	189	1	cancer	cancer	NOUN
bjp-14679	189	2	cell	cell	NOUN
bjp-14679	189	3	int	int	NOUN
bjp-14679	189	4	.	.	PUNCT
bjp-14679	190	1	2003	2003	NUM
bjp-14679	190	2	;	;	PUNCT
bjp-14679	190	3	3	3	NUM
bjp-14679	190	4	:	:	SYM
bjp-14679	190	5	17	17	NUM
bjp-14679	190	6	.	.	PUNCT
bjp-14679	191	1	qian	qian	PROPN
bjp-14679	191	2	x	x	PROPN
bjp-14679	191	3	,	,	PUNCT
bjp-14679	191	4	karpova	karpova	PROPN
bjp-14679	191	5	t	t	PROPN
bjp-14679	191	6	,	,	PUNCT
bjp-14679	191	7	sheppard	sheppard	PROPN
bjp-14679	191	8	am	am	PROPN
bjp-14679	191	9	,	,	PUNCT
bjp-14679	191	10	mcnally	mcnally	PROPN
bjp-14679	191	11	j	j	PROPN
bjp-14679	191	12	,	,	PUNCT
bjp-14679	191	13	lowy	lowy	PROPN
bjp-14679	191	14	dr	dr	PROPN
bjp-14679	191	15	.	.	PROPN
bjp-14679	191	16	ecadherin	ecadherin	PROPN
bjp-14679	191	17	mediated	mediate	VERB
bjp-14679	191	18	adhesion	adhesion	NOUN
bjp-14679	191	19	inhibits	inhibit	VERB
bjp-14679	191	20	ligand	ligand	ADJ
bjp-14679	191	21	dependent	dependent	ADJ
bjp-14679	191	22	activation	activation	NOUN
bjp-14679	191	23	of	of	ADP
bjp-14679	191	24	diverse	diverse	ADJ
bjp-14679	191	25	receptor	receptor	NOUN
bjp-14679	191	26	tyrosine	tyrosine	NOUN
bjp-14679	191	27	kinases	kinase	NOUN
bjp-14679	191	28	.	.	PUNCT
bjp-14679	192	1	embo	embo	PROPN
bjp-14679	192	2	j.	j.	PROPN
bjp-14679	192	3	2004	2004	PROPN
bjp-14679	192	4	;	;	PUNCT
bjp-14679	192	5	23	23	NUM
bjp-14679	192	6	:	:	SYM
bjp-14679	192	7	1739	1739	NUM
bjp-14679	192	8	-	-	SYM
bjp-14679	192	9	48	48	NUM
bjp-14679	192	10	.	.	PUNCT
bjp-14679	193	1	ramensky	ramensky	PROPN
bjp-14679	193	2	v	v	PROPN
bjp-14679	193	3	,	,	PUNCT
bjp-14679	193	4	bork	bork	NOUN
bjp-14679	193	5	p	p	NOUN
bjp-14679	193	6	,	,	PUNCT
bjp-14679	193	7	sunyaev	sunyaev	PROPN
bjp-14679	193	8	s.	s.	PROPN
bjp-14679	193	9	human	human	PROPN
bjp-14679	193	10	non	non	ADJ
bjp-14679	193	11	-	-	ADJ
bjp-14679	193	12	synonymous	synonymous	ADJ
bjp-14679	193	13	snps	snps	NOUN
bjp-14679	193	14	:	:	PUNCT
bjp-14679	193	15	server	server	NOUN
bjp-14679	193	16	and	and	CCONJ
bjp-14679	193	17	survey	survey	NOUN
bjp-14679	193	18	.	.	PUNCT
bjp-14679	194	1	nucleic	nucleic	ADJ
bjp-14679	194	2	acids	acid	NOUN
bjp-14679	194	3	res	re	NOUN
bjp-14679	194	4	.	.	PUNCT
bjp-14679	194	5	2002	2002	NUM
bjp-14679	194	6	;	;	PUNCT
bjp-14679	194	7	30	30	NUM
bjp-14679	194	8	:	:	SYM
bjp-14679	194	9	3894	3894	NUM
bjp-14679	194	10	–	–	PUNCT
bjp-14679	194	11	3900	3900	NUM
bjp-14679	194	12	.	.	PUNCT
bjp-14679	195	1	smigielski	smigielski	PROPN
bjp-14679	195	2	em	em	PRON
bjp-14679	195	3	,	,	PUNCT
bjp-14679	195	4	sirotkin	sirotkin	PROPN
bjp-14679	195	5	k	k	PROPN
bjp-14679	195	6	,	,	PUNCT
bjp-14679	195	7	ward	ward	PROPN
bjp-14679	195	8	m	m	PROPN
bjp-14679	195	9	,	,	PUNCT
bjp-14679	196	1	sherry	sherry	PROPN
bjp-14679	196	2	st	st	PROPN
bjp-14679	196	3	.	.	PROPN
bjp-14679	196	4	dbsnp	dbsnp	PROPN
bjp-14679	196	5	:	:	PUNCT
bjp-14679	196	6	a	a	DET
bjp-14679	196	7	database	database	NOUN
bjp-14679	196	8	of	of	ADP
bjp-14679	196	9	single	single	ADJ
bjp-14679	196	10	nucleotide	nucleotide	NOUN
bjp-14679	196	11	polymorphisms	polymorphism	NOUN
bjp-14679	196	12	.	.	PUNCT
bjp-14679	197	1	nucleic	nucleic	ADJ
bjp-14679	197	2	acids	acid	NOUN
bjp-14679	197	3	res	re	NOUN
bjp-14679	197	4	.	.	PROPN
bjp-14679	197	5	2000	2000	NUM
bjp-14679	197	6	;	;	PUNCT
bjp-14679	197	7	28	28	NUM
bjp-14679	197	8	:	:	PUNCT
bjp-14679	197	9	352	352	NUM
bjp-14679	197	10	-	-	SYM
bjp-14679	197	11	55	55	NUM
bjp-14679	197	12	.	.	PUNCT
bjp-14679	198	1	teng	teng	PROPN
bjp-14679	198	2	s	s	PROPN
bjp-14679	198	3	,	,	PUNCT
bjp-14679	198	4	madej	madej	PROPN
bjp-14679	198	5	t	t	PROPN
bjp-14679	198	6	,	,	PUNCT
bjp-14679	198	7	panchenko	panchenko	VERB
bjp-14679	198	8	a	a	PRON
bjp-14679	198	9	,	,	PUNCT
bjp-14679	198	10	alexov	alexov	PROPN
bjp-14679	198	11	e.	e.	PROPN
bjp-14679	198	12	modeling	modeling	PROPN
bjp-14679	198	13	effects	effect	NOUN
bjp-14679	198	14	of	of	ADP
bjp-14679	198	15	human	human	ADJ
bjp-14679	198	16	single	single	ADJ
bjp-14679	198	17	nucleotide	nucleotide	ADJ
bjp-14679	198	18	polymorphisms	polymorphism	NOUN
bjp-14679	198	19	on	on	ADP
bjp-14679	198	20	protein	protein	NOUN
bjp-14679	198	21	–	–	PUNCT
bjp-14679	198	22	protein	protein	NOUN
bjp-14679	198	23	interactions	interaction	NOUN
bjp-14679	198	24	.	.	PUNCT
bjp-14679	199	1	biophy	biophy	NOUN
bjp-14679	199	2	j.	j.	PROPN
bjp-14679	199	3	2009	2009	NUM
bjp-14679	199	4	;	;	PUNCT
bjp-14679	199	5	96	96	NUM
bjp-14679	199	6	:	:	SYM
bjp-14679	199	7	2178	2178	NUM
bjp-14679	199	8	-	-	SYM
bjp-14679	199	9	88	88	NUM
bjp-14679	199	10	.	.	PUNCT
bjp-14679	200	1	zhang	zhang	PROPN
bjp-14679	200	2	y	y	PROPN
bjp-14679	200	3	,	,	PUNCT
bjp-14679	200	4	liu	liu	PROPN
bjp-14679	200	5	x	x	PROPN
bjp-14679	200	6	,	,	PUNCT
bjp-14679	200	7	fan	fan	PROPN
bjp-14679	200	8	y	y	PROPN
bjp-14679	200	9	,	,	PUNCT
bjp-14679	200	10	ding	ding	PROPN
bjp-14679	200	11	j	j	PROPN
bjp-14679	200	12	,	,	PUNCT
bjp-14679	200	13	xu	xu	PROPN
bjp-14679	200	14	a	a	X
bjp-14679	200	15	,	,	PUNCT
bjp-14679	200	16	zhou	zhou	PROPN
bjp-14679	200	17	x	x	PROPN
bjp-14679	200	18	,	,	PUNCT
bjp-14679	200	19	hu	hu	PROPN
bjp-14679	200	20	x	x	PROPN
bjp-14679	200	21	,	,	PUNCT
bjp-14679	200	22	zhu	zhu	PROPN
bjp-14679	200	23	m	m	PROPN
bjp-14679	200	24	,	,	PUNCT
bjp-14679	201	1	zhang	zhang	PROPN
bjp-14679	201	2	x	x	PROPN
bjp-14679	201	3	,	,	PUNCT
bjp-14679	201	4	li	li	PROPN
bjp-14679	201	5	s	s	PROPN
bjp-14679	201	6	,	,	PUNCT
bjp-14679	201	7	wu	wu	PROPN
bjp-14679	201	8	j	j	PROPN
bjp-14679	201	9	,	,	PUNCT
bjp-14679	201	10	cao	cao	PROPN
bjp-14679	201	11	h	h	PROPN
bjp-14679	201	12	,	,	PUNCT
bjp-14679	201	13	li	li	PROPN
bjp-14679	201	14	j	j	PROPN
bjp-14679	201	15	,	,	PUNCT
bjp-14679	201	16	wang	wang	PROPN
bjp-14679	201	17	y.	y.	PROPN
bjp-14679	201	18	germline	germline	VERB
bjp-14679	201	19	mutations	mutation	NOUN
bjp-14679	201	20	and	and	CCONJ
bjp-14679	201	21	polymorphic	polymorphic	ADJ
bjp-14679	201	22	variants	variant	NOUN
bjp-14679	201	23	in	in	ADP
bjp-14679	201	24	mmr	mmr	PROPN
bjp-14679	201	25	,	,	PUNCT
bjp-14679	201	26	e	e	NOUN
bjp-14679	201	27	-	-	NOUN
bjp-14679	201	28	cadherin	cadherin	NOUN
bjp-14679	201	29	and	and	CCONJ
bjp-14679	201	30	myh	myh	NOUN
bjp-14679	201	31	genes	gene	NOUN
bjp-14679	201	32	associated	associate	VERB
bjp-14679	201	33	with	with	ADP
bjp-14679	201	34	familial	familial	ADJ
bjp-14679	201	35	gastric	gastric	ADJ
bjp-14679	201	36	cancer	cancer	NOUN
bjp-14679	201	37	in	in	ADP
bjp-14679	201	38	jiangsu	jiangsu	PROPN
bjp-14679	201	39	of	of	ADP
bjp-14679	201	40	china	china	PROPN
bjp-14679	201	41	.	.	PUNCT
bjp-14679	202	1	int	int	PROPN
bjp-14679	202	2	j	j	PROPN
bjp-14679	202	3	cancer	cancer	NOUN
bjp-14679	202	4	.	.	PUNCT
bjp-14679	203	1	2006	2006	NUM
bjp-14679	203	2	;	;	PUNCT
bjp-14679	203	3	119	119	NUM
bjp-14679	203	4	:	:	SYM
bjp-14679	203	5	2592	2592	NUM
bjp-14679	203	6	-	-	SYM
bjp-14679	203	7	96	96	NUM
bjp-14679	203	8	.	.	PUNCT
bjp-14679	204	1	zhang	zhang	PROPN
bjp-14679	204	2	y	y	PROPN
bjp-14679	204	3	,	,	PUNCT
bjp-14679	204	4	wang	wang	PROPN
bjp-14679	204	5	q.	q.	PROPN
bjp-14679	204	6	sunitinib	sunitinib	PROPN
bjp-14679	204	7	reverse	reverse	VERB
bjp-14679	204	8	multidrug	multidrug	NOUN
bjp-14679	204	9	resistance	resistance	NOUN
bjp-14679	204	10	in	in	ADP
bjp-14679	204	11	gastric	gastric	ADJ
bjp-14679	204	12	cancer	cancer	NOUN
bjp-14679	204	13	cells	cell	NOUN
bjp-14679	204	14	by	by	ADP
bjp-14679	204	15	modulating	modulate	VERB
bjp-14679	204	16	stat3	stat3	NOUN
bjp-14679	204	17	and	and	CCONJ
bjp-14679	204	18	inhibiting	inhibit	VERB
bjp-14679	204	19	p	p	NOUN
bjp-14679	204	20	-	-	PUNCT
bjp-14679	204	21	gp	gp	NOUN
bjp-14679	204	22	function	function	NOUN
bjp-14679	204	23	.	.	PUNCT
bjp-14679	205	1	cell	cell	NOUN
bjp-14679	205	2	biochem	biochem	PROPN
bjp-14679	205	3	biophy	biophy	NOUN
bjp-14679	205	4	.	.	PUNCT
bjp-14679	206	1	2013	2013	NUM
bjp-14679	206	2	;	;	PUNCT
bjp-14679	206	3	2013	2013	NUM
bjp-14679	206	4	.	.	PUNCT
bjp-14679	207	1	author	author	NOUN
bjp-14679	207	2	info	info	NOUN
bjp-14679	207	3	karuppasamy	karuppasamy	PROPN
bjp-14679	207	4	ramanathan	ramanathan	PROPN
bjp-14679	207	5	(	(	PUNCT
bjp-14679	207	6	principal	principal	ADJ
bjp-14679	207	7	contact	contact	NOUN
bjp-14679	207	8	)	)	PUNCT
bjp-14679	207	9	e	e	NOUN
bjp-14679	207	10	-	-	NOUN
bjp-14679	207	11	mail	mail	NOUN
bjp-14679	207	12	:	:	PUNCT
bjp-14679	207	13	kramanathan@vit.ac.in	kramanathan@vit.ac.in	ADP
bjp-14679	207	14	bangladesh	bangladesh	PROPN
bjp-14679	207	15	j	j	PROPN
bjp-14679	207	16	pharmacol	pharmacol	PROPN
bjp-14679	207	17	2013	2013	NUM
bjp-14679	207	18	;	;	PUNCT
bjp-14679	207	19	8	8	NUM
bjp-14679	207	20	:	:	SYM
bjp-14679	207	21	207	207	NUM
bjp-14679	207	22	-	-	SYM
bjp-14679	207	23	213	213	NUM
bjp-14679	207	24	213	213	NUM
bjp-14679	207	25	dateprinted	dateprinte	VERB
bjp-14679	207	26	:	:	PUNCT
bjp-14679	207	27	this	this	DET
bjp-14679	207	28	article	article	NOUN
bjp-14679	207	29	was	be	AUX
bjp-14679	207	30	downloaded	download	VERB
bjp-14679	207	31	by	by	ADP
bjp-14679	207	32	you	you	PRON
bjp-14679	207	33	on	on	ADP
bjp-14679	207	34	:	:	PUNCT
bjp-14679	207	35	jun	jun	PROPN
bjp-14679	207	36	10	10	NUM
bjp-14679	207	37	,	,	PUNCT
bjp-14679	207	38	2018	2018	NUM