id	sid	tid	token	lemma	pos
bjp-15259	1	1	bangladesh	bangladesh	PROPN
bjp-15259	1	2	journal	journal	PROPN
bjp-15259	1	3	of	of	ADP
bjp-15259	1	4	pharmacology	pharmacology	NOUN
bjp-15259	1	5	research	research	NOUN
bjp-15259	1	6	article	article	NOUN
bjp-15259	1	7	a	a	DET
bjp-15259	1	8	computational	computational	ADJ
bjp-15259	1	9	approach	approach	NOUN
bjp-15259	1	10	to	to	PART
bjp-15259	1	11	analyze	analyze	VERB
bjp-15259	1	12	the	the	DET
bjp-15259	1	13	missense	missense	NOUN
bjp-15259	1	14	mutations	mutation	NOUN
bjp-15259	1	15	in	in	ADP
bjp-15259	1	16	human	human	ADJ
bjp-15259	1	17	angiogenin	angiogenin	NOUN
bjp-15259	1	18	variants	variant	NOUN
bjp-15259	1	19	leading	lead	VERB
bjp-15259	1	20	to	to	ADP
bjp-15259	1	21	amyotrophic	amyotrophic	ADJ
bjp-15259	1	22	lateral	lateral	ADJ
bjp-15259	1	23	sclerosis	sclerosis	NOUN
bjp-15259	1	24	bjp	bjp	PROPN
bjp-15259	1	25	introduction	introduction	NOUN
bjp-15259	1	26	amyotrophic	amyotrophic	ADJ
bjp-15259	1	27	lateral	lateral	ADJ
bjp-15259	1	28	sclerosis	sclerosis	NOUN
bjp-15259	1	29	(	(	PUNCT
bjp-15259	1	30	als	als	NOUN
bjp-15259	1	31	)	)	PUNCT
bjp-15259	1	32	is	be	AUX
bjp-15259	1	33	a	a	DET
bjp-15259	1	34	fatal	fatal	ADJ
bjp-15259	1	35	neurodegenerative	neurodegenerative	ADJ
bjp-15259	1	36	disorder	disorder	NOUN
bjp-15259	1	37	characterized	characterize	VERB
bjp-15259	1	38	by	by	ADP
bjp-15259	1	39	selective	selective	ADJ
bjp-15259	1	40	destruction	destruction	NOUN
bjp-15259	1	41	of	of	ADP
bjp-15259	1	42	motor	motor	NOUN
bjp-15259	1	43	neurons	neuron	NOUN
bjp-15259	1	44	,	,	PUNCT
bjp-15259	1	45	resulting	result	VERB
bjp-15259	1	46	paralysis	paralysis	NOUN
bjp-15259	1	47	in	in	ADP
bjp-15259	1	48	stages	stage	NOUN
bjp-15259	1	49	and	and	CCONJ
bjp-15259	1	50	death	death	NOUN
bjp-15259	1	51	within	within	ADP
bjp-15259	1	52	a	a	DET
bjp-15259	1	53	few	few	ADJ
bjp-15259	1	54	years	year	NOUN
bjp-15259	1	55	from	from	ADP
bjp-15259	1	56	onset	onset	NOUN
bjp-15259	1	57	(	(	PUNCT
bjp-15259	1	58	bruijin	bruijin	NOUN
bjp-15259	1	59	et	et	PROPN
bjp-15259	1	60	al	al	PROPN
bjp-15259	1	61	.	.	PROPN
bjp-15259	1	62	,	,	PUNCT
bjp-15259	1	63	2004	2004	NUM
bjp-15259	1	64	)	)	PUNCT
bjp-15259	1	65	.	.	PUNCT
bjp-15259	2	1	in	in	ADP
bjp-15259	2	2	the	the	DET
bjp-15259	2	3	past	past	NOUN
bjp-15259	2	4	decade	decade	NOUN
bjp-15259	2	5	,	,	PUNCT
bjp-15259	2	6	a	a	DET
bjp-15259	2	7	small	small	ADJ
bjp-15259	2	8	number	number	NOUN
bjp-15259	2	9	of	of	ADP
bjp-15259	2	10	genes	gene	NOUN
bjp-15259	2	11	involved	involve	VERB
bjp-15259	2	12	in	in	ADP
bjp-15259	2	13	the	the	DET
bjp-15259	2	14	etiology	etiology	NOUN
bjp-15259	2	15	of	of	ADP
bjp-15259	2	16	the	the	DET
bjp-15259	2	17	disease	disease	NOUN
bjp-15259	2	18	have	have	AUX
bjp-15259	2	19	been	be	AUX
bjp-15259	2	20	identified	identify	VERB
bjp-15259	2	21	.	.	PUNCT
bjp-15259	3	1	angiogenin	angiogenin	NOUN
bjp-15259	3	2	(	(	PUNCT
bjp-15259	3	3	ang	ang	PROPN
bjp-15259	3	4	)	)	PUNCT
bjp-15259	3	5	,	,	PUNCT
bjp-15259	3	6	which	which	PRON
bjp-15259	3	7	encodes	encode	VERB
bjp-15259	3	8	an	an	DET
bjp-15259	3	9	angiogenic	angiogenic	ADJ
bjp-15259	3	10	protein	protein	NOUN
bjp-15259	3	11	,	,	PUNCT
bjp-15259	3	12	has	have	AUX
bjp-15259	3	13	been	be	AUX
bjp-15259	3	14	recently	recently	ADV
bjp-15259	3	15	identified	identify	VERB
bjp-15259	3	16	as	as	ADP
bjp-15259	3	17	a	a	DET
bjp-15259	3	18	candidate	candidate	NOUN
bjp-15259	3	19	susceptibility	susceptibility	NOUN
bjp-15259	3	20	gene	gene	NOUN
bjp-15259	3	21	for	for	ADP
bjp-15259	3	22	als	als	NOUN
bjp-15259	3	23	in	in	ADP
bjp-15259	3	24	the	the	DET
bjp-15259	3	25	irish	irish	ADJ
bjp-15259	3	26	and	and	CCONJ
bjp-15259	3	27	scottish	scottish	ADJ
bjp-15259	3	28	population	population	NOUN
bjp-15259	3	29	by	by	ADP
bjp-15259	3	30	greenway	greenway	PROPN
bjp-15259	3	31	et	et	PROPN
bjp-15259	3	32	al	al	PROPN
bjp-15259	3	33	(	(	PUNCT
bjp-15259	3	34	greenway	greenway	PROPN
bjp-15259	3	35	et	et	PROPN
bjp-15259	3	36	al	al	PROPN
bjp-15259	3	37	.	.	PROPN
bjp-15259	3	38	,	,	PUNCT
bjp-15259	3	39	2004	2004	NUM
bjp-15259	3	40	)	)	PUNCT
bjp-15259	3	41	.	.	PUNCT
bjp-15259	4	1	the	the	DET
bjp-15259	4	2	ang	ang	PROPN
bjp-15259	4	3	gene	gene	NOUN
bjp-15259	4	4	provides	provide	VERB
bjp-15259	4	5	instructions	instruction	NOUN
bjp-15259	4	6	for	for	ADP
bjp-15259	4	7	making	make	VERB
bjp-15259	4	8	a	a	DET
bjp-15259	4	9	protein	protein	NOUN
bjp-15259	4	10	called	call	VERB
bjp-15259	4	11	angiogenin	angiogenin	NOUN
bjp-15259	4	12	.	.	PUNCT
bjp-15259	5	1	this	this	DET
bjp-15259	5	2	protein	protein	NOUN
bjp-15259	5	3	promotes	promote	VERB
bjp-15259	5	4	the	the	DET
bjp-15259	5	5	formation	formation	NOUN
bjp-15259	5	6	of	of	ADP
bjp-15259	5	7	new	new	ADJ
bjp-15259	5	8	blood	blood	NOUN
bjp-15259	5	9	vessels	vessel	NOUN
bjp-15259	5	10	from	from	ADP
bjp-15259	5	11	pre	pre	ADJ
bjp-15259	5	12	-	-	ADJ
bjp-15259	5	13	existing	exist	VERB
bjp-15259	5	14	blood	blood	NOUN
bjp-15259	5	15	vessels	vessel	NOUN
bjp-15259	5	16	through	through	ADP
bjp-15259	5	17	a	a	DET
bjp-15259	5	18	process	process	NOUN
bjp-15259	5	19	called	call	VERB
bjp-15259	5	20	angiogenesis	angiogenesis	NOUN
bjp-15259	5	21	.	.	PUNCT
bjp-15259	6	1	the	the	DET
bjp-15259	6	2	ang	ang	PROPN
bjp-15259	6	3	gene	gene	NOUN
bjp-15259	6	4	is	be	AUX
bjp-15259	6	5	located	locate	VERB
bjp-15259	6	6	on	on	ADP
bjp-15259	6	7	the	the	DET
bjp-15259	6	8	long	long	ADJ
bjp-15259	6	9	(	(	PUNCT
bjp-15259	6	10	q	q	NOUN
bjp-15259	6	11	)	)	PUNCT
bjp-15259	6	12	arm	arm	NOUN
bjp-15259	6	13	of	of	ADP
bjp-15259	6	14	chromosome	chromosome	NOUN
bjp-15259	6	15	14	14	NUM
bjp-15259	6	16	between	between	ADP
bjp-15259	6	17	positions	position	NOUN
bjp-15259	6	18	11.1	11.1	NUM
bjp-15259	6	19	and	and	CCONJ
bjp-15259	6	20	11.2	11.2	NUM
bjp-15259	6	21	.	.	PUNCT
bjp-15259	7	1	more	more	ADV
bjp-15259	7	2	precisely	precisely	ADV
bjp-15259	7	3	,	,	PUNCT
bjp-15259	7	4	the	the	DET
bjp-15259	7	5	ang	ang	PROPN
bjp-15259	7	6	gene	gene	NOUN
bjp-15259	7	7	is	be	AUX
bjp-15259	7	8	located	locate	VERB
bjp-15259	7	9	from	from	ADP
bjp-15259	7	10	base	base	NOUN
bjp-15259	7	11	pair	pair	NOUN
bjp-15259	7	12	21,152,335	21,152,335	NUM
bjp-15259	7	13	to	to	PART
bjp-15259	7	14	base	base	VERB
bjp-15259	7	15	pair	pair	NOUN
bjp-15259	7	16	21,162,344	21,162,344	NUM
bjp-15259	7	17	on	on	ADP
bjp-15259	7	18	chromosome	chromosome	NOUN
bjp-15259	7	19	14	14	NUM
bjp-15259	7	20	.	.	PUNCT
bjp-15259	8	1	the	the	DET
bjp-15259	8	2	protein	protein	NOUN
bjp-15259	8	3	aggregation	aggregation	NOUN
bjp-15259	8	4	,	,	PUNCT
bjp-15259	8	5	defective	defective	ADJ
bjp-15259	8	6	axonal	axonal	ADJ
bjp-15259	8	7	transport	transport	NOUN
bjp-15259	8	8	,	,	PUNCT
bjp-15259	8	9	oxidative	oxidative	ADJ
bjp-15259	8	10	stress	stress	NOUN
bjp-15259	8	11	,	,	PUNCT
bjp-15259	8	12	dysfunctional	dysfunctional	ADJ
bjp-15259	8	13	growth	growth	NOUN
bjp-15259	8	14	factor	factor	NOUN
bjp-15259	8	15	signaling	signal	VERB
bjp-15259	8	16	,	,	PUNCT
bjp-15259	8	17	mitochondrial	mitochondrial	ADJ
bjp-15259	8	18	dysfunction	dysfunction	NOUN
bjp-15259	8	19	and	and	CCONJ
bjp-15259	8	20	excitotoxicity	excitotoxicity	NOUN
bjp-15259	8	21	are	be	AUX
bjp-15259	8	22	some	some	PRON
bjp-15259	8	23	of	of	ADP
bjp-15259	8	24	the	the	DET
bjp-15259	8	25	factors	factor	NOUN
bjp-15259	8	26	found	find	VERB
bjp-15259	8	27	to	to	PART
bjp-15259	8	28	be	be	AUX
bjp-15259	8	29	combined	combine	VERB
bjp-15259	8	30	to	to	ADP
bjp-15259	8	31	the	the	DET
bjp-15259	8	32	inception	inception	NOUN
bjp-15259	8	33	of	of	ADP
bjp-15259	8	34	als	al	NOUN
bjp-15259	8	35	.	.	PUNCT
bjp-15259	9	1	around	around	ADP
bjp-15259	9	2	10	10	NUM
bjp-15259	9	3	%	%	NOUN
bjp-15259	9	4	of	of	ADP
bjp-15259	9	5	als	als	NOUN
bjp-15259	9	6	cases	case	NOUN
bjp-15259	9	7	are	be	AUX
bjp-15259	9	8	inherited	inherit	VERB
bjp-15259	9	9	genetically	genetically	ADV
bjp-15259	9	10	,	,	PUNCT
bjp-15259	9	11	but	but	CCONJ
bjp-15259	9	12	the	the	DET
bjp-15259	9	13	other	other	ADJ
bjp-15259	9	14	90	90	NUM
bjp-15259	9	15	%	%	NOUN
bjp-15259	9	16	have	have	VERB
bjp-15259	9	17	no	no	DET
bjp-15259	9	18	clear	clear	ADJ
bjp-15259	9	19	genetic	genetic	ADJ
bjp-15259	9	20	cause	cause	NOUN
bjp-15259	9	21	(	(	PUNCT
bjp-15259	9	22	dion	dion	NOUN
bjp-15259	9	23	et	et	NOUN
bjp-15259	9	24	al	al	PROPN
bjp-15259	9	25	.	.	PROPN
bjp-15259	9	26	,	,	PUNCT
bjp-15259	9	27	2009	2009	NUM
bjp-15259	9	28	)	)	PUNCT
bjp-15259	9	29	.	.	PUNCT
bjp-15259	10	1	many	many	ADJ
bjp-15259	10	2	als	als	NOUN
bjp-15259	10	3	-	-	PUNCT
bjp-15259	10	4	linked	link	VERB
bjp-15259	10	5	genes	gene	NOUN
bjp-15259	10	6	have	have	AUX
bjp-15259	10	7	been	be	AUX
bjp-15259	10	8	identified	identify	VERB
bjp-15259	10	9	,	,	PUNCT
bjp-15259	10	10	including	include	VERB
bjp-15259	10	11	sod1	sod1	NOUN
bjp-15259	10	12	(	(	PUNCT
bjp-15259	10	13	encoding	encode	VERB
bjp-15259	10	14	superoxide	superoxide	NOUN
bjp-15259	10	15	dismutase	dismutase	NOUN
bjp-15259	10	16	1	1	NUM
bjp-15259	10	17	)	)	PUNCT
bjp-15259	10	18	,	,	PUNCT
bjp-15259	10	19	tardbp	tardbp	NOUN
bjp-15259	10	20	(	(	PUNCT
bjp-15259	10	21	encoding	encode	VERB
bjp-15259	10	22	tar	tar	NOUN
bjp-15259	10	23	dna	dna	NOUN
bjp-15259	10	24	binding	bind	VERB
bjp-15259	10	25	protein-43	protein-43	PROPN
bjp-15259	10	26	)	)	PUNCT
bjp-15259	10	27	,	,	PUNCT
bjp-15259	10	28	fus	fus	PROPN
bjp-15259	10	29	/	/	SYM
bjp-15259	10	30	tls	tls	PROPN
bjp-15259	10	31	(	(	PUNCT
bjp-15259	10	32	encoding	encode	VERB
bjp-15259	10	33	rna	rna	NOUN
bjp-15259	10	34	-	-	PUNCT
bjp-15259	10	35	binding	bind	VERB
bjp-15259	10	36	protein	protein	NOUN
bjp-15259	10	37	fus	fus	PROPN
bjp-15259	10	38	)	)	PUNCT
bjp-15259	10	39	,	,	PUNCT
bjp-15259	10	40	and	and	CCONJ
bjp-15259	10	41	others	other	NOUN
bjp-15259	10	42	(	(	PUNCT
bjp-15259	10	43	vande	vande	PROPN
bjp-15259	10	44	velde	velde	PROPN
bjp-15259	10	45	et	et	PROPN
bjp-15259	10	46	al	al	PROPN
bjp-15259	10	47	.	.	PROPN
bjp-15259	10	48	,	,	PUNCT
bjp-15259	10	49	2011	2011	NUM
bjp-15259	10	50	)	)	PUNCT
bjp-15259	10	51	.	.	PUNCT
bjp-15259	11	1	among	among	ADP
bjp-15259	11	2	other	other	ADJ
bjp-15259	11	3	genes	gene	NOUN
bjp-15259	11	4	,	,	PUNCT
bjp-15259	11	5	heterozygous	heterozygous	ADJ
bjp-15259	11	6	missense	missense	NOUN
bjp-15259	11	7	mutations	mutation	NOUN
bjp-15259	11	8	in	in	ADP
bjp-15259	11	9	ang	ang	PROPN
bjp-15259	11	10	have	have	AUX
bjp-15259	11	11	been	be	AUX
bjp-15259	11	12	associated	associate	VERB
bjp-15259	11	13	with	with	ADP
bjp-15259	11	14	als	als	NOUN
bjp-15259	11	15	(	(	PUNCT
bjp-15259	11	16	greenway	greenway	PROPN
bjp-15259	11	17	et	et	PROPN
bjp-15259	11	18	al	al	PROPN
bjp-15259	11	19	.	.	PROPN
bjp-15259	11	20	)	)	PUNCT
bjp-15259	11	21	.	.	PUNCT
bjp-15259	12	1	mature	mature	ADJ
bjp-15259	12	2	ang	ang	PROPN
bjp-15259	12	3	is	be	AUX
bjp-15259	12	4	a	a	DET
bjp-15259	12	5	14	14	NUM
bjp-15259	12	6	kda	kda	NOUN
bjp-15259	12	7	,	,	PUNCT
bjp-15259	12	8	123	123	NUM
bjp-15259	12	9	amino	amino	NOUN
bjp-15259	12	10	acid	acid	NOUN
bjp-15259	12	11	,	,	PUNCT
bjp-15259	12	12	secreted	secrete	VERB
bjp-15259	12	13	protein	protein	NOUN
bjp-15259	12	14	primarily	primarily	ADV
bjp-15259	12	15	produced	produce	VERB
bjp-15259	12	16	by	by	ADP
bjp-15259	12	17	the	the	DET
bjp-15259	12	18	liver	liver	NOUN
bjp-15259	12	19	(	(	PUNCT
bjp-15259	12	20	kishikawa	kishikawa	PROPN
bjp-15259	12	21	et	et	PROPN
bjp-15259	12	22	al	al	PROPN
bjp-15259	12	23	.	.	PROPN
bjp-15259	12	24	,	,	PUNCT
bjp-15259	12	25	2008	2008	NUM
bjp-15259	12	26	)	)	PUNCT
bjp-15259	12	27	.	.	PUNCT
bjp-15259	13	1	ang	ang	PROPN
bjp-15259	13	2	is	be	AUX
bjp-15259	13	3	broadly	broadly	ADV
bjp-15259	13	4	expressed	express	VERB
bjp-15259	13	5	throughout	throughout	ADP
bjp-15259	13	6	the	the	DET
bjp-15259	13	7	adult	adult	NOUN
bjp-15259	13	8	human	human	ADJ
bjp-15259	13	9	nervous	nervous	ADJ
bjp-15259	13	10	system	system	NOUN
bjp-15259	13	11	and	and	CCONJ
bjp-15259	13	12	is	be	AUX
bjp-15259	13	13	neuroprotective	neuroprotective	ADJ
bjp-15259	13	14	(	(	PUNCT
bjp-15259	13	15	kieran	kieran	PROPN
bjp-15259	13	16	et	et	PROPN
bjp-15259	13	17	al	al	PROPN
bjp-15259	13	18	.	.	PROPN
bjp-15259	13	19	,	,	PUNCT
bjp-15259	13	20	2008	2008	NUM
bjp-15259	13	21	;	;	PUNCT
bjp-15259	13	22	kishikawa	kishikawa	PROPN
bjp-15259	13	23	et	et	PROPN
bjp-15259	13	24	al	al	PROPN
bjp-15259	13	25	.	.	PROPN
bjp-15259	13	26	,	,	PUNCT
bjp-15259	13	27	2008	2008	NUM
bjp-15259	13	28	)	)	PUNCT
bjp-15259	13	29	.	.	PUNCT
bjp-15259	14	1	further	far	ADV
bjp-15259	14	2	,	,	PUNCT
bjp-15259	14	3	in	in	ADP
bjp-15259	14	4	als	als	NOUN
bjp-15259	14	5	patients	patient	NOUN
bjp-15259	14	6	,	,	PUNCT
bjp-15259	14	7	the	the	DET
bjp-15259	14	8	identified	identify	VERB
bjp-15259	14	9	ang	ang	INTJ
bjp-15259	14	10	missense	missense	NOUN
bjp-15259	14	11	variants	variant	NOUN
bjp-15259	14	12	cause	cause	VERB
bjp-15259	14	13	the	the	DET
bjp-15259	14	14	reduced	reduce	VERB
bjp-15259	14	15	angiogenic	angiogenic	ADJ
bjp-15259	14	16	activity	activity	NOUN
bjp-15259	14	17	of	of	ADP
bjp-15259	14	18	ang	ang	NOUN
bjp-15259	14	19	in	in	ADP
bjp-15259	14	20	endothelial	endothelial	ADJ
bjp-15259	14	21	cells	cell	NOUN
bjp-15259	14	22	(	(	PUNCT
bjp-15259	14	23	wu	wu	PROPN
bjp-15259	14	24	et	et	PROPN
bjp-15259	14	25	a	a	DET
bjp-15259	14	26	journal	journal	NOUN
bjp-15259	14	27	of	of	ADP
bjp-15259	14	28	the	the	DET
bjp-15259	14	29	bangladesh	bangladesh	NOUN
bjp-15259	14	30	pharmacological	pharmacological	ADJ
bjp-15259	14	31	society	society	NOUN
bjp-15259	14	32	(	(	PUNCT
bjp-15259	14	33	bdps	bdps	NOUN
bjp-15259	14	34	)	)	PUNCT
bjp-15259	14	35	bangladesh	bangladesh	PROPN
bjp-15259	14	36	j	j	PROPN
bjp-15259	14	37	pharmacol	pharmacol	PROPN
bjp-15259	14	38	2013	2013	NUM
bjp-15259	14	39	;	;	PUNCT
bjp-15259	14	40	8	8	NUM
bjp-15259	14	41	:	:	PUNCT
bjp-15259	14	42	382	382	NUM
bjp-15259	14	43	-	-	SYM
bjp-15259	14	44	389	389	NUM
bjp-15259	14	45	journal	journal	NOUN
bjp-15259	14	46	homepage	homepage	NOUN
bjp-15259	14	47	:	:	PUNCT
bjp-15259	14	48	www.banglajol.info	www.banglajol.info	PROPN
bjp-15259	14	49	abstracted	abstract	VERB
bjp-15259	14	50	/	/	SYM
bjp-15259	14	51	indexed	index	VERB
bjp-15259	14	52	in	in	ADP
bjp-15259	14	53	academic	academic	ADJ
bjp-15259	14	54	search	search	NOUN
bjp-15259	14	55	complete	complete	ADJ
bjp-15259	14	56	,	,	PUNCT
bjp-15259	14	57	agroforestry	agroforestry	NOUN
bjp-15259	14	58	abstracts	abstract	NOUN
bjp-15259	14	59	,	,	PUNCT
bjp-15259	14	60	asia	asia	PROPN
bjp-15259	14	61	journals	journal	NOUN
bjp-15259	14	62	online	online	ADV
bjp-15259	14	63	,	,	PUNCT
bjp-15259	14	64	bangladesh	bangladesh	NOUN
bjp-15259	14	65	journals	journal	NOUN
bjp-15259	14	66	online	online	ADV
bjp-15259	14	67	,	,	PUNCT
bjp-15259	14	68	biological	biological	ADJ
bjp-15259	14	69	abstracts	abstract	NOUN
bjp-15259	14	70	,	,	PUNCT
bjp-15259	14	71	biosis	biosis	NOUN
bjp-15259	14	72	previews	preview	NOUN
bjp-15259	14	73	,	,	PUNCT
bjp-15259	14	74	cab	cab	NOUN
bjp-15259	14	75	abstracts	abstract	NOUN
bjp-15259	14	76	,	,	PUNCT
bjp-15259	14	77	current	current	ADJ
bjp-15259	14	78	abstracts	abstract	NOUN
bjp-15259	14	79	,	,	PUNCT
bjp-15259	14	80	directory	directory	NOUN
bjp-15259	14	81	of	of	ADP
bjp-15259	14	82	open	open	ADJ
bjp-15259	14	83	access	access	NOUN
bjp-15259	14	84	journals	journal	NOUN
bjp-15259	14	85	,	,	PUNCT
bjp-15259	14	86	embase	embase	NOUN
bjp-15259	14	87	/	/	SYM
bjp-15259	14	88	excerpta	excerpta	NOUN
bjp-15259	14	89	medica	medica	NOUN
bjp-15259	14	90	,	,	PUNCT
bjp-15259	14	91	global	global	ADJ
bjp-15259	14	92	health	health	NOUN
bjp-15259	14	93	,	,	PUNCT
bjp-15259	14	94	google	google	PROPN
bjp-15259	14	95	scholar	scholar	NOUN
bjp-15259	14	96	,	,	PUNCT
bjp-15259	14	97	hinari	hinari	X
bjp-15259	14	98	(	(	PUNCT
bjp-15259	14	99	who	who	PRON
bjp-15259	14	100	)	)	PUNCT
bjp-15259	14	101	,	,	PUNCT
bjp-15259	14	102	international	international	ADJ
bjp-15259	14	103	pharmaceutical	pharmaceutical	ADJ
bjp-15259	14	104	abstracts	abstract	NOUN
bjp-15259	14	105	,	,	PUNCT
bjp-15259	14	106	open	open	ADJ
bjp-15259	14	107	j	j	PROPN
bjp-15259	14	108	-	-	PUNCT
bjp-15259	14	109	gate	gate	NOUN
bjp-15259	14	110	,	,	PUNCT
bjp-15259	14	111	science	science	NOUN
bjp-15259	14	112	citation	citation	NOUN
bjp-15259	14	113	index	index	NOUN
bjp-15259	14	114	expanded	expand	VERB
bjp-15259	14	115	,	,	PUNCT
bjp-15259	14	116	scopus	scopus	NOUN
bjp-15259	14	117	and	and	CCONJ
bjp-15259	14	118	social	social	ADJ
bjp-15259	14	119	sciences	sciences	PROPN
bjp-15259	14	120	citation	citation	NOUN
bjp-15259	14	121	index	index	NOUN
bjp-15259	14	122	issn	issn	PROPN
bjp-15259	14	123	:	:	PUNCT
bjp-15259	14	124	1991	1991	NUM
bjp-15259	14	125	-	-	SYM
bjp-15259	14	126	0088	0088	NUM
bjp-15259	14	127	abstract	abstract	NOUN
bjp-15259	14	128	the	the	DET
bjp-15259	14	129	most	most	ADV
bjp-15259	14	130	deleterious	deleterious	ADJ
bjp-15259	14	131	missense	missense	NOUN
bjp-15259	14	132	mutations	mutation	NOUN
bjp-15259	14	133	of	of	ADP
bjp-15259	14	134	angiogenin	angiogenin	NOUN
bjp-15259	14	135	forming	form	VERB
bjp-15259	14	136	amyotrophic	amyotrophic	ADJ
bjp-15259	14	137	lateral	lateral	ADJ
bjp-15259	14	138	sclerosis	sclerosis	NOUN
bjp-15259	14	139	were	be	AUX
bjp-15259	14	140	identified	identify	VERB
bjp-15259	14	141	computationally	computationally	ADV
bjp-15259	14	142	and	and	CCONJ
bjp-15259	14	143	the	the	DET
bjp-15259	14	144	substrate	substrate	NOUN
bjp-15259	14	145	binding	bind	VERB
bjp-15259	14	146	efficiencies	efficiency	NOUN
bjp-15259	14	147	of	of	ADP
bjp-15259	14	148	these	these	DET
bjp-15259	14	149	mutations	mutation	NOUN
bjp-15259	14	150	were	be	AUX
bjp-15259	14	151	also	also	ADV
bjp-15259	14	152	analyzed	analyze	VERB
bjp-15259	14	153	.	.	PUNCT
bjp-15259	15	1	out	out	ADP
bjp-15259	15	2	of	of	ADP
bjp-15259	15	3	12	12	NUM
bjp-15259	15	4	variants	variant	NOUN
bjp-15259	15	5	,	,	PUNCT
bjp-15259	15	6	imutant2.0	imutant2.0	NUM
bjp-15259	15	7	,	,	PUNCT
bjp-15259	15	8	sift	sift	ADJ
bjp-15259	15	9	and	and	CCONJ
bjp-15259	15	10	polyphen	polyphen	ADV
bjp-15259	15	11	programs	program	NOUN
bjp-15259	15	12	identified	identify	VERB
bjp-15259	15	13	3	3	NUM
bjp-15259	15	14	variants	variant	NOUN
bjp-15259	15	15	that	that	PRON
bjp-15259	15	16	were	be	AUX
bjp-15259	15	17	less	less	ADV
bjp-15259	15	18	stable	stable	ADJ
bjp-15259	15	19	,	,	PUNCT
bjp-15259	15	20	deleterious	deleterious	ADJ
bjp-15259	15	21	and	and	CCONJ
bjp-15259	15	22	damaging	damaging	ADJ
bjp-15259	15	23	respectively	respectively	ADV
bjp-15259	15	24	.	.	PUNCT
bjp-15259	16	1	these	these	DET
bjp-15259	16	2	3	3	NUM
bjp-15259	16	3	variants	variant	NOUN
bjp-15259	16	4	were	be	AUX
bjp-15259	16	5	modeled	model	VERB
bjp-15259	16	6	to	to	PART
bjp-15259	16	7	find	find	VERB
bjp-15259	16	8	their	their	PRON
bjp-15259	16	9	conformational	conformational	ADJ
bjp-15259	16	10	changes	change	NOUN
bjp-15259	16	11	in	in	ADP
bjp-15259	16	12	concern	concern	NOUN
bjp-15259	16	13	with	with	ADP
bjp-15259	16	14	native	native	ADJ
bjp-15259	16	15	angiogenin	angiogenin	NOUN
bjp-15259	16	16	through	through	ADP
bjp-15259	16	17	rmsd	rmsd	NOUN
bjp-15259	16	18	calculation	calculation	NOUN
bjp-15259	16	19	and	and	CCONJ
bjp-15259	16	20	total	total	ADJ
bjp-15259	16	21	energy	energy	NOUN
bjp-15259	16	22	.	.	PUNCT
bjp-15259	17	1	docking	docking	NOUN
bjp-15259	17	2	of	of	ADP
bjp-15259	17	3	native	native	ADJ
bjp-15259	17	4	and	and	CCONJ
bjp-15259	17	5	3	3	NUM
bjp-15259	17	6	mutants	mutant	NOUN
bjp-15259	17	7	with	with	ADP
bjp-15259	17	8	ribonuclease	ribonuclease	NOUN
bjp-15259	17	9	inhibitor	inhibitor	NOUN
bjp-15259	17	10	was	be	AUX
bjp-15259	17	11	performed	perform	VERB
bjp-15259	17	12	to	to	PART
bjp-15259	17	13	describe	describe	VERB
bjp-15259	17	14	the	the	DET
bjp-15259	17	15	binding	bind	VERB
bjp-15259	17	16	efficiencies	efficiency	NOUN
bjp-15259	17	17	of	of	ADP
bjp-15259	17	18	those	those	DET
bjp-15259	17	19	detrimental	detrimental	ADJ
bjp-15259	17	20	missense	missense	NOUN
bjp-15259	17	21	mutations	mutation	NOUN
bjp-15259	17	22	.	.	PUNCT
bjp-15259	18	1	by	by	ADP
bjp-15259	18	2	computing	compute	VERB
bjp-15259	18	3	the	the	DET
bjp-15259	18	4	binding	bind	VERB
bjp-15259	18	5	amino	amino	NOUN
bjp-15259	18	6	acids	acid	NOUN
bjp-15259	18	7	’	'	PUNCT
bjp-15259	18	8	flexibility	flexibility	NOUN
bjp-15259	18	9	of	of	ADP
bjp-15259	18	10	angiogenin	angiogenin	NOUN
bjp-15259	18	11	and	and	CCONJ
bjp-15259	18	12	computing	compute	VERB
bjp-15259	18	13	the	the	DET
bjp-15259	18	14	binding	bind	VERB
bjp-15259	18	15	free	free	ADJ
bjp-15259	18	16	energy	energy	NOUN
bjp-15259	18	17	(	(	PUNCT
bjp-15259	18	18	δg	δg	PROPN
bjp-15259	18	19	)	)	PUNCT
bjp-15259	18	20	between	between	ADP
bjp-15259	18	21	native	native	ADJ
bjp-15259	18	22	and	and	CCONJ
bjp-15259	18	23	mutant	mutant	ADJ
bjp-15259	18	24	complexes	complex	NOUN
bjp-15259	18	25	,	,	PUNCT
bjp-15259	18	26	the	the	DET
bjp-15259	18	27	loss	loss	NOUN
bjp-15259	18	28	in	in	ADP
bjp-15259	18	29	binding	bind	VERB
bjp-15259	18	30	affinity	affinity	NOUN
bjp-15259	18	31	with	with	ADP
bjp-15259	18	32	their	their	PRON
bjp-15259	18	33	interacting	interact	VERB
bjp-15259	18	34	protein	protein	NOUN
bjp-15259	18	35	namely	namely	ADV
bjp-15259	18	36	ribonuclease	ribonuclease	NOUN
bjp-15259	18	37	inhibitor	inhibitor	NOUN
bjp-15259	18	38	was	be	AUX
bjp-15259	18	39	investigated	investigate	VERB
bjp-15259	18	40	.	.	PUNCT
bjp-15259	19	1	article	article	NOUN
bjp-15259	19	2	info	info	NOUN
bjp-15259	19	3	received	receive	VERB
bjp-15259	19	4	:	:	PUNCT
bjp-15259	19	5	11	11	NUM
bjp-15259	19	6	june	june	PROPN
bjp-15259	19	7	2013	2013	NUM
bjp-15259	19	8	accepted	accept	VERB
bjp-15259	19	9	:	:	PUNCT
bjp-15259	19	10	3	3	NUM
bjp-15259	19	11	october	october	PROPN
bjp-15259	19	12	2013	2013	NUM
bjp-15259	19	13	available	available	ADJ
bjp-15259	19	14	online	online	NOUN
bjp-15259	19	15	:	:	PUNCT
bjp-15259	19	16	13	13	NUM
bjp-15259	19	17	november	november	PROPN
bjp-15259	19	18	2013	2013	NUM
bjp-15259	19	19	doi	doi	NOUN
bjp-15259	19	20	:	:	PUNCT
bjp-15259	19	21	10.3329	10.3329	NUM
bjp-15259	19	22	/	/	SYM
bjp-15259	19	23	bjp.v8i4.15259	bjp.v8i4.15259	PROPN
bjp-15259	19	24	cite	cite	VERB
bjp-15259	19	25	this	this	DET
bjp-15259	19	26	article	article	NOUN
bjp-15259	19	27	:	:	PUNCT
bjp-15259	19	28	sreevishnupriya	sreevishnupriya	PROPN
bjp-15259	19	29	k	k	PROPN
bjp-15259	19	30	,	,	PUNCT
bjp-15259	19	31	rajasekaran	rajasekaran	PROPN
bjp-15259	19	32	r.	r.	PROPN
bjp-15259	19	33	a	a	DET
bjp-15259	19	34	computational	computational	ADJ
bjp-15259	19	35	approach	approach	NOUN
bjp-15259	19	36	to	to	PART
bjp-15259	19	37	analyze	analyze	VERB
bjp-15259	19	38	the	the	DET
bjp-15259	19	39	missense	missense	NOUN
bjp-15259	19	40	mutations	mutation	NOUN
bjp-15259	19	41	in	in	ADP
bjp-15259	19	42	human	human	ADJ
bjp-15259	19	43	angiogenin	angiogenin	NOUN
bjp-15259	19	44	variants	variant	NOUN
bjp-15259	19	45	leading	lead	VERB
bjp-15259	19	46	to	to	ADP
bjp-15259	19	47	amyotrophic	amyotrophic	ADJ
bjp-15259	19	48	lateral	lateral	ADJ
bjp-15259	19	49	sclerosis	sclerosis	NOUN
bjp-15259	19	50	.	.	PUNCT
bjp-15259	20	1	bangladesh	bangladesh	PROPN
bjp-15259	20	2	j	j	PROPN
bjp-15259	20	3	pharmacol	pharmacol	PROPN
bjp-15259	20	4	.	.	PUNCT
bjp-15259	21	1	2013	2013	NUM
bjp-15259	21	2	;	;	PUNCT
bjp-15259	21	3	8	8	NUM
bjp-15259	21	4	:	:	PUNCT
bjp-15259	21	5	382	382	NUM
bjp-15259	21	6	-	-	SYM
bjp-15259	21	7	89	89	NUM
bjp-15259	21	8	.	.	PUNCT
bjp-15259	22	1	this	this	DET
bjp-15259	22	2	work	work	NOUN
bjp-15259	22	3	is	be	AUX
bjp-15259	22	4	licensed	license	VERB
bjp-15259	22	5	under	under	ADP
bjp-15259	22	6	a	a	DET
bjp-15259	22	7	creative	creative	ADJ
bjp-15259	22	8	commons	common	NOUN
bjp-15259	22	9	attribution	attribution	NOUN
bjp-15259	22	10	3.0	3.0	NUM
bjp-15259	22	11	license	license	NOUN
bjp-15259	22	12	.	.	PUNCT
bjp-15259	23	1	you	you	PRON
bjp-15259	23	2	are	be	AUX
bjp-15259	23	3	free	free	ADJ
bjp-15259	23	4	to	to	PART
bjp-15259	23	5	copy	copy	VERB
bjp-15259	23	6	,	,	PUNCT
bjp-15259	23	7	distribute	distribute	VERB
bjp-15259	23	8	and	and	CCONJ
bjp-15259	23	9	perform	perform	VERB
bjp-15259	23	10	the	the	DET
bjp-15259	23	11	work	work	NOUN
bjp-15259	23	12	.	.	PUNCT
bjp-15259	24	1	you	you	PRON
bjp-15259	24	2	must	must	AUX
bjp-15259	24	3	attribute	attribute	VERB
bjp-15259	24	4	the	the	DET
bjp-15259	24	5	work	work	NOUN
bjp-15259	24	6	in	in	ADP
bjp-15259	24	7	the	the	DET
bjp-15259	24	8	manner	manner	NOUN
bjp-15259	24	9	specified	specify	VERB
bjp-15259	24	10	by	by	ADP
bjp-15259	24	11	the	the	DET
bjp-15259	24	12	author	author	NOUN
bjp-15259	24	13	or	or	CCONJ
bjp-15259	24	14	licensor	licensor	NOUN
bjp-15259	24	15	.	.	PUNCT
bjp-15259	25	1	a	a	DET
bjp-15259	25	2	computational	computational	ADJ
bjp-15259	25	3	approach	approach	NOUN
bjp-15259	25	4	to	to	PART
bjp-15259	25	5	analyze	analyze	VERB
bjp-15259	25	6	the	the	DET
bjp-15259	25	7	missense	missense	NOUN
bjp-15259	25	8	mutations	mutation	NOUN
bjp-15259	25	9	in	in	ADP
bjp-15259	25	10	human	human	ADJ
bjp-15259	25	11	angiogenin	angiogenin	NOUN
bjp-15259	25	12	variants	variant	NOUN
bjp-15259	25	13	leading	lead	VERB
bjp-15259	25	14	to	to	ADP
bjp-15259	25	15	amyotrophic	amyotrophic	ADJ
bjp-15259	25	16	lateral	lateral	ADJ
bjp-15259	25	17	sclerosis	sclerosis	NOUN
bjp-15259	25	18	k.	k.	PROPN
bjp-15259	25	19	sreevishnupriya	sreevishnupriya	PROPN
bjp-15259	25	20	and	and	CCONJ
bjp-15259	25	21	ramalingar	ramalingar	VERB
bjp-15259	25	22	rajasekaran	rajasekaran	NOUN
bjp-15259	25	23	bioinformatics	bioinformatics	NOUN
bjp-15259	25	24	division	division	NOUN
bjp-15259	25	25	,	,	PUNCT
bjp-15259	25	26	school	school	NOUN
bjp-15259	25	27	of	of	ADP
bjp-15259	25	28	biosciences	bioscience	NOUN
bjp-15259	25	29	and	and	CCONJ
bjp-15259	25	30	technology	technology	NOUN
bjp-15259	25	31	,	,	PUNCT
bjp-15259	25	32	vellore	vellore	PROPN
bjp-15259	25	33	institute	institute	PROPN
bjp-15259	25	34	of	of	ADP
bjp-15259	25	35	technology	technology	PROPN
bjp-15259	25	36	,	,	PUNCT
bjp-15259	25	37	vellore	vellore	NOUN
bjp-15259	25	38	632014	632014	NUM
bjp-15259	25	39	,	,	PUNCT
bjp-15259	25	40	tamil	tamil	PROPN
bjp-15259	25	41	nadu	nadu	PROPN
bjp-15259	25	42	,	,	PUNCT
bjp-15259	25	43	india	india	PROPN
bjp-15259	25	44	.	.	PUNCT
bjp-15259	26	1	al	al	PROPN
bjp-15259	26	2	.	.	PROPN
bjp-15259	26	3	,	,	PUNCT
bjp-15259	26	4	2007	2007	NUM
bjp-15259	26	5	)	)	PUNCT
bjp-15259	26	6	and	and	CCONJ
bjp-15259	26	7	impairment	impairment	NOUN
bjp-15259	26	8	of	of	ADP
bjp-15259	26	9	neurite	neurite	ADJ
bjp-15259	26	10	extension	extension	NOUN
bjp-15259	26	11	and	and	CCONJ
bjp-15259	26	12	survival	survival	NOUN
bjp-15259	26	13	of	of	ADP
bjp-15259	26	14	motor	motor	NOUN
bjp-15259	26	15	neurons	neuron	NOUN
bjp-15259	26	16	(	(	PUNCT
bjp-15259	26	17	kieran	kieran	PROPN
bjp-15259	26	18	et	et	PROPN
bjp-15259	26	19	al	al	PROPN
bjp-15259	26	20	.	.	PROPN
bjp-15259	26	21	,	,	PUNCT
bjp-15259	26	22	2008	2008	NUM
bjp-15259	26	23	;	;	PUNCT
bjp-15259	26	24	subramanian	subramanian	PROPN
bjp-15259	26	25	et	et	PROPN
bjp-15259	26	26	al	al	PROPN
bjp-15259	26	27	.	.	PROPN
bjp-15259	26	28	,	,	PUNCT
bjp-15259	26	29	2008	2008	NUM
bjp-15259	26	30	)	)	PUNCT
bjp-15259	26	31	.	.	PUNCT
bjp-15259	27	1	ang	ang	PROPN
bjp-15259	27	2	parameterized	parameterize	VERB
bjp-15259	27	3	three	three	NUM
bjp-15259	27	4	characteristic	characteristic	ADJ
bjp-15259	27	5	features	feature	NOUN
bjp-15259	27	6	:	:	PUNCT
bjp-15259	27	7	(	(	PUNCT
bjp-15259	27	8	i	i	NOUN
bjp-15259	27	9	)	)	PUNCT
bjp-15259	27	10	the	the	DET
bjp-15259	27	11	characteristic	characteristic	ADJ
bjp-15259	27	12	ribonuclease	ribonuclease	NOUN
bjp-15259	27	13	activity	activity	NOUN
bjp-15259	27	14	towards	towards	ADP
bjp-15259	27	15	poly-	poly-	NOUN
bjp-15259	27	16	,	,	PUNCT
bjp-15259	27	17	diand	diand	NOUN
bjp-15259	27	18	cyclic	cyclic	ADJ
bjp-15259	27	19	nucleotides	nucleotide	NOUN
bjp-15259	27	20	is	be	AUX
bjp-15259	27	21	104106	104106	NUM
bjp-15259	27	22	lower	low	ADJ
bjp-15259	27	23	and	and	CCONJ
bjp-15259	27	24	also	also	ADV
bjp-15259	27	25	varied	varied	ADJ
bjp-15259	27	26	enzymatic	enzymatic	ADJ
bjp-15259	27	27	specificity	specificity	NOUN
bjp-15259	27	28	(	(	PUNCT
bjp-15259	27	29	shapiro	shapiro	PROPN
bjp-15259	27	30	et	et	PROPN
bjp-15259	27	31	al	al	PROPN
bjp-15259	27	32	.	.	PROPN
bjp-15259	27	33	,	,	PUNCT
bjp-15259	27	34	1986	1986	NUM
bjp-15259	27	35	)	)	PUNCT
bjp-15259	27	36	(	(	PUNCT
bjp-15259	27	37	ii	ii	NOUN
bjp-15259	27	38	)	)	PUNCT
bjp-15259	27	39	the	the	DET
bjp-15259	27	40	region	region	NOUN
bjp-15259	27	41	between	between	ADP
bjp-15259	27	42	residues	residue	NOUN
bjp-15259	27	43	58–70	58–70	PROPN
bjp-15259	27	44	seems	seem	VERB
bjp-15259	27	45	to	to	PART
bjp-15259	27	46	constitute	constitute	VERB
bjp-15259	27	47	a	a	DET
bjp-15259	27	48	'	'	PUNCT
bjp-15259	27	49	cell	cell	NOUN
bjp-15259	27	50	-	-	PUNCT
bjp-15259	27	51	binding	bind	VERB
bjp-15259	27	52	site	site	NOUN
bjp-15259	27	53	'	'	PUNCT
bjp-15259	27	54	,	,	PUNCT
bjp-15259	27	55	independent	independent	ADJ
bjp-15259	27	56	from	from	ADP
bjp-15259	27	57	the	the	DET
bjp-15259	27	58	active	active	ADJ
bjp-15259	27	59	site	site	NOUN
bjp-15259	27	60	(	(	PUNCT
bjp-15259	27	61	hallahan	hallahan	NOUN
bjp-15259	27	62	et	et	PROPN
bjp-15259	27	63	al	al	PROPN
bjp-15259	27	64	.	.	PROPN
bjp-15259	27	65	,	,	PUNCT
bjp-15259	27	66	1991	1991	NUM
bjp-15259	27	67	,	,	PUNCT
bjp-15259	27	68	1992	1992	NUM
bjp-15259	27	69	)	)	PUNCT
bjp-15259	27	70	perhaps	perhaps	ADV
bjp-15259	27	71	involved	involve	VERB
bjp-15259	27	72	essentially	essentially	ADV
bjp-15259	27	73	in	in	ADP
bjp-15259	27	74	protein	protein	NOUN
bjp-15259	27	75	-	-	PUNCT
bjp-15259	27	76	protein	protein	NOUN
bjp-15259	27	77	interactions	interaction	NOUN
bjp-15259	27	78	;	;	PUNCT
bjp-15259	27	79	and	and	CCONJ
bjp-15259	27	80	(	(	PUNCT
bjp-15259	27	81	iii	iii	X
bjp-15259	27	82	)	)	PUNCT
bjp-15259	27	83	the	the	DET
bjp-15259	27	84	region	region	NOUN
bjp-15259	27	85	31	31	NUM
bjp-15259	27	86	-	-	SYM
bjp-15259	27	87	35	35	NUM
bjp-15259	27	88	contributes	contribute	VERB
bjp-15259	27	89	a	a	DET
bjp-15259	27	90	nucleolar	nucleolar	ADJ
bjp-15259	27	91	localization	localization	NOUN
bjp-15259	27	92	signal	signal	NOUN
bjp-15259	27	93	(	(	PUNCT
bjp-15259	27	94	moroianu	moroianu	PROPN
bjp-15259	27	95	et	et	PROPN
bjp-15259	27	96	al	al	PROPN
bjp-15259	27	97	.	.	PROPN
bjp-15259	27	98	,	,	PUNCT
bjp-15259	27	99	1994	1994	NUM
bjp-15259	27	100	)	)	PUNCT
bjp-15259	27	101	.	.	PUNCT
bjp-15259	28	1	a	a	DET
bjp-15259	28	2	large	large	ADJ
bjp-15259	28	3	(	(	PUNCT
bjp-15259	28	4	~450	~450	NOUN
bjp-15259	28	5	residues	residue	NOUN
bjp-15259	28	6	,	,	PUNCT
bjp-15259	28	7	~49	~49	NOUN
bjp-15259	28	8	kda	kda	NOUN
bjp-15259	28	9	)	)	PUNCT
bjp-15259	28	10	,	,	PUNCT
bjp-15259	28	11	acidic	acidic	ADJ
bjp-15259	28	12	(	(	PUNCT
bjp-15259	28	13	pi	pi	NOUN
bjp-15259	28	14	~4.7	~4.7	PROPN
bjp-15259	28	15	)	)	PUNCT
bjp-15259	28	16	protein	protein	NOUN
bjp-15259	28	17	referred	refer	VERB
bjp-15259	28	18	to	to	ADP
bjp-15259	28	19	as	as	ADP
bjp-15259	28	20	ribonuclease	ribonuclease	NOUN
bjp-15259	28	21	inhibitor	inhibitor	NOUN
bjp-15259	28	22	(	(	PUNCT
bjp-15259	28	23	ri	ri	NOUN
bjp-15259	28	24	)	)	PUNCT
bjp-15259	28	25	which	which	PRON
bjp-15259	28	26	has	have	VERB
bjp-15259	28	27	leucine	leucine	NOUN
bjp-15259	28	28	-	-	PUNCT
bjp-15259	28	29	rich	rich	ADJ
bjp-15259	28	30	repeat	repeat	NOUN
bjp-15259	28	31	is	be	AUX
bjp-15259	28	32	tightly	tightly	ADV
bjp-15259	28	33	complexed	complexe	VERB
bjp-15259	28	34	to	to	ADP
bjp-15259	28	35	some	some	DET
bjp-15259	28	36	ribonucleases	ribonuclease	NOUN
bjp-15259	28	37	.	.	PUNCT
bjp-15259	29	1	also	also	ADV
bjp-15259	29	2	being	be	AUX
bjp-15259	29	3	an	an	DET
bjp-15259	29	4	important	important	ADJ
bjp-15259	29	5	cellular	cellular	ADJ
bjp-15259	29	6	protein	protein	NOUN
bjp-15259	29	7	,	,	PUNCT
bjp-15259	29	8	it	it	PRON
bjp-15259	29	9	consists	consist	VERB
bjp-15259	29	10	~0.1	~0.1	NOUN
bjp-15259	29	11	%	%	NOUN
bjp-15259	29	12	of	of	ADP
bjp-15259	29	13	all	all	DET
bjp-15259	29	14	cellular	cellular	ADJ
bjp-15259	29	15	protein	protein	NOUN
bjp-15259	29	16	by	by	ADP
bjp-15259	29	17	weight	weight	NOUN
bjp-15259	29	18	,	,	PUNCT
bjp-15259	29	19	and	and	CCONJ
bjp-15259	29	20	found	find	VERB
bjp-15259	29	21	to	to	PART
bjp-15259	29	22	regulate	regulate	VERB
bjp-15259	29	23	the	the	DET
bjp-15259	29	24	rna	rna	NOUN
bjp-15259	29	25	lifetime	lifetime	NOUN
bjp-15259	29	26	(	(	PUNCT
bjp-15259	29	27	shapiro	shapiro	PROPN
bjp-15259	29	28	,	,	PUNCT
bjp-15259	29	29	2001	2001	NUM
bjp-15259	29	30	)	)	PUNCT
bjp-15259	29	31	.	.	PUNCT
bjp-15259	30	1	possibly	possibly	ADV
bjp-15259	30	2	,	,	PUNCT
bjp-15259	30	3	for	for	ADP
bjp-15259	30	4	any	any	DET
bjp-15259	30	5	protein	protein	NOUN
bjp-15259	30	6	-	-	PUNCT
bjp-15259	30	7	protein	protein	NOUN
bjp-15259	30	8	interaction	interaction	NOUN
bjp-15259	30	9	,	,	PUNCT
bjp-15259	30	10	the	the	DET
bjp-15259	30	11	affinity	affinity	NOUN
bjp-15259	30	12	of	of	ADP
bjp-15259	30	13	ri	ri	PROPN
bjp-15259	30	14	for	for	ADP
bjp-15259	30	15	ribonucleases	ribonuclease	NOUN
bjp-15259	30	16	found	find	VERB
bjp-15259	30	17	to	to	PART
bjp-15259	30	18	be	be	AUX
bjp-15259	30	19	the	the	DET
bjp-15259	30	20	highest	high	ADJ
bjp-15259	30	21	;	;	PUNCT
bjp-15259	30	22	the	the	DET
bjp-15259	30	23	dissociation	dissociation	NOUN
bjp-15259	30	24	constant	constant	ADJ
bjp-15259	30	25	of	of	ADP
bjp-15259	30	26	the	the	DET
bjp-15259	30	27	ri	ri	PROPN
bjp-15259	30	28	-	-	PUNCT
bjp-15259	30	29	rnase	rnase	PROPN
bjp-15259	30	30	.	.	PUNCT
bjp-15259	31	1	a	a	DET
bjp-15259	31	2	complex	complex	NOUN
bjp-15259	31	3	is	be	AUX
bjp-15259	31	4	around	around	ADV
bjp-15259	31	5	20	20	NUM
bjp-15259	31	6	fm	fm	NOUN
bjp-15259	31	7	under	under	ADP
bjp-15259	31	8	physiological	physiological	ADJ
bjp-15259	31	9	conditions	condition	NOUN
bjp-15259	31	10	whereas	whereas	SCONJ
bjp-15259	31	11	it	it	PRON
bjp-15259	31	12	is	be	AUX
bjp-15259	31	13	even	even	ADV
bjp-15259	31	14	smaller	small	ADJ
bjp-15259	31	15	(	(	PUNCT
bjp-15259	31	16	<	<	X
bjp-15259	31	17	1	1	NUM
bjp-15259	31	18	fm	fm	NOUN
bjp-15259	31	19	)	)	PUNCT
bjp-15259	31	20	for	for	ADP
bjp-15259	31	21	the	the	DET
bjp-15259	31	22	ri	ri	PROPN
bjp-15259	31	23	-	-	PUNCT
bjp-15259	31	24	angiogenin	angiogenin	NOUN
bjp-15259	31	25	complex	complex	NOUN
bjp-15259	31	26	.	.	PUNCT
bjp-15259	32	1	eminently	eminently	ADV
bjp-15259	32	2	,	,	PUNCT
bjp-15259	32	3	ri	ri	PROPN
bjp-15259	32	4	could	could	AUX
bjp-15259	32	5	bind	bind	VERB
bjp-15259	32	6	a	a	DET
bjp-15259	32	7	huge	huge	ADJ
bjp-15259	32	8	variety	variety	NOUN
bjp-15259	32	9	of	of	ADP
bjp-15259	32	10	rnases	rnase	NOUN
bjp-15259	32	11	,	,	PUNCT
bjp-15259	32	12	in	in	ADP
bjp-15259	32	13	spite	spite	NOUN
bjp-15259	32	14	of	of	ADP
bjp-15259	32	15	its	its	PRON
bjp-15259	32	16	low	low	ADJ
bjp-15259	32	17	sequence	sequence	NOUN
bjp-15259	32	18	identity	identity	NOUN
bjp-15259	32	19	.	.	PUNCT
bjp-15259	33	1	rnases	rnase	NOUN
bjp-15259	33	2	bind	bind	VERB
bjp-15259	33	3	as	as	ADP
bjp-15259	33	4	a	a	DET
bjp-15259	33	5	"	"	PUNCT
bjp-15259	33	6	cork	cork	NOUN
bjp-15259	33	7	in	in	ADP
bjp-15259	33	8	the	the	DET
bjp-15259	33	9	bottle	bottle	NOUN
bjp-15259	33	10	"	"	PUNCT
bjp-15259	33	11	as	as	SCONJ
bjp-15259	33	12	indicated	indicate	VERB
bjp-15259	33	13	by	by	ADP
bjp-15259	33	14	structural	structural	ADJ
bjp-15259	33	15	studies	study	NOUN
bjp-15259	33	16	,	,	PUNCT
bjp-15259	33	17	associating	associate	VERB
bjp-15259	33	18	primarily	primarily	ADV
bjp-15259	33	19	with	with	ADP
bjp-15259	33	20	the	the	DET
bjp-15259	33	21	c	c	NOUN
bjp-15259	33	22	-	-	PUNCT
bjp-15259	33	23	terminal	terminal	ADJ
bjp-15259	33	24	end	end	NOUN
bjp-15259	33	25	of	of	ADP
bjp-15259	33	26	ri	ri	NOUN
bjp-15259	33	27	;	;	PUNCT
bjp-15259	33	28	the	the	DET
bjp-15259	33	29	interaction	interaction	NOUN
bjp-15259	33	30	is	be	AUX
bjp-15259	33	31	highly	highly	ADV
bjp-15259	33	32	electrostatic	electrostatic	ADJ
bjp-15259	33	33	however	however	ADV
bjp-15259	33	34	occupies	occupy	VERB
bjp-15259	33	35	a	a	DET
bjp-15259	33	36	huge	huge	ADJ
bjp-15259	33	37	surface	surface	NOUN
bjp-15259	33	38	area	area	NOUN
bjp-15259	33	39	(	(	PUNCT
bjp-15259	33	40	>	>	X
bjp-15259	33	41	25	25	NUM
bjp-15259	33	42	nm2	nm2	NUM
bjp-15259	33	43	)	)	PUNCT
bjp-15259	33	44	.	.	PUNCT
bjp-15259	34	1	the	the	DET
bjp-15259	34	2	cytotoxic	cytotoxic	ADJ
bjp-15259	34	3	and	and	CCONJ
bjp-15259	34	4	cytostatic	cytostatic	ADJ
bjp-15259	34	5	effects	effect	NOUN
bjp-15259	34	6	of	of	ADP
bjp-15259	34	7	ribonuclease	ribonuclease	NOUN
bjp-15259	34	8	made	make	VERB
bjp-15259	34	9	it	it	PRON
bjp-15259	34	10	to	to	PART
bjp-15259	34	11	examine	examine	VERB
bjp-15259	34	12	as	as	ADP
bjp-15259	34	13	potential	potential	ADJ
bjp-15259	34	14	cancer	cancer	NOUN
bjp-15259	34	15	therapeutics	therapeutic	NOUN
bjp-15259	34	16	.	.	PUNCT
bjp-15259	35	1	hence	hence	ADV
bjp-15259	35	2	ri	ri	PROPN
bjp-15259	35	3	's	's	PART
bjp-15259	35	4	affinity	affinity	NOUN
bjp-15259	35	5	for	for	ADP
bjp-15259	35	6	ribonucleases	ribonuclease	NOUN
bjp-15259	35	7	is	be	AUX
bjp-15259	35	8	important	important	ADJ
bjp-15259	35	9	(	(	PUNCT
bjp-15259	35	10	kobe	kobe	PROPN
bjp-15259	35	11	et	et	PROPN
bjp-15259	35	12	al	al	PROPN
bjp-15259	35	13	.	.	PROPN
bjp-15259	35	14	,	,	PUNCT
bjp-15259	35	15	1996	1996	NUM
bjp-15259	35	16	)	)	PUNCT
bjp-15259	35	17	.	.	PUNCT
bjp-15259	36	1	recent	recent	ADJ
bjp-15259	36	2	experimental	experimental	ADJ
bjp-15259	36	3	studies	study	NOUN
bjp-15259	36	4	suggest	suggest	VERB
bjp-15259	36	5	that	that	SCONJ
bjp-15259	36	6	the	the	DET
bjp-15259	36	7	loss	loss	NOUN
bjp-15259	36	8	of	of	ADP
bjp-15259	36	9	either	either	CCONJ
bjp-15259	36	10	nuclear	nuclear	ADJ
bjp-15259	36	11	translocation	translocation	NOUN
bjp-15259	36	12	activity	activity	NOUN
bjp-15259	36	13	,	,	PUNCT
bjp-15259	36	14	ribonucleolytic	ribonucleolytic	ADJ
bjp-15259	36	15	activity	activity	NOUN
bjp-15259	36	16	or	or	CCONJ
bjp-15259	36	17	both	both	PRON
bjp-15259	36	18	leads	lead	VERB
bjp-15259	36	19	to	to	ADP
bjp-15259	36	20	total	total	ADJ
bjp-15259	36	21	loss	loss	NOUN
bjp-15259	36	22	of	of	ADP
bjp-15259	36	23	angiogenin	angiogenin	NOUN
bjp-15259	36	24	function	function	NOUN
bjp-15259	36	25	due	due	ADP
bjp-15259	36	26	to	to	ADP
bjp-15259	36	27	mutations	mutation	NOUN
bjp-15259	36	28	in	in	ADP
bjp-15259	36	29	ang	ang	NOUN
bjp-15259	36	30	which	which	PRON
bjp-15259	36	31	leads	lead	VERB
bjp-15259	36	32	to	to	ADP
bjp-15259	36	33	als	als	VERB
bjp-15259	36	34	(	(	PUNCT
bjp-15259	36	35	wu	wu	PROPN
bjp-15259	36	36	et	et	PROPN
bjp-15259	36	37	al	al	PROPN
bjp-15259	36	38	.	.	PROPN
bjp-15259	36	39	,	,	PUNCT
bjp-15259	36	40	2007	2007	NUM
bjp-15259	36	41	)	)	PUNCT
bjp-15259	36	42	.	.	PUNCT
bjp-15259	37	1	above	above	ADP
bjp-15259	37	2	14	14	NUM
bjp-15259	37	3	ang	ang	PROPN
bjp-15259	37	4	mutations	mutation	NOUN
bjp-15259	37	5	found	find	VERB
bjp-15259	37	6	to	to	PART
bjp-15259	37	7	be	be	AUX
bjp-15259	37	8	linked	link	VERB
bjp-15259	37	9	with	with	ADP
bjp-15259	37	10	als	als	NOUN
bjp-15259	37	11	wherein	wherein	ADJ
bjp-15259	37	12	10	10	NUM
bjp-15259	37	13	have	have	AUX
bjp-15259	37	14	been	be	AUX
bjp-15259	37	15	analyzed	analyze	VERB
bjp-15259	37	16	intensively	intensively	ADV
bjp-15259	37	17	,	,	PUNCT
bjp-15259	37	18	whereas	whereas	SCONJ
bjp-15259	37	19	the	the	DET
bjp-15259	37	20	functional	functional	ADJ
bjp-15259	37	21	loss	loss	NOUN
bjp-15259	37	22	of	of	ADP
bjp-15259	37	23	ang	ang	NOUN
bjp-15259	37	24	caused	cause	VERB
bjp-15259	37	25	by	by	ADP
bjp-15259	37	26	these	these	DET
bjp-15259	37	27	mutations	mutation	NOUN
bjp-15259	37	28	and	and	CCONJ
bjp-15259	37	29	the	the	DET
bjp-15259	37	30	cause	cause	NOUN
bjp-15259	37	31	of	of	ADP
bjp-15259	37	32	its	its	PRON
bjp-15259	37	33	molecular	molecular	ADJ
bjp-15259	37	34	mechanism	mechanism	NOUN
bjp-15259	37	35	is	be	AUX
bjp-15259	37	36	unclear	unclear	ADJ
bjp-15259	37	37	(	(	PUNCT
bjp-15259	37	38	padhi	padhi	VERB
bjp-15259	37	39	et	et	PROPN
bjp-15259	37	40	al	al	PROPN
bjp-15259	37	41	.	.	PROPN
bjp-15259	37	42	,	,	PUNCT
bjp-15259	37	43	2012	2012	NUM
bjp-15259	37	44	)	)	PUNCT
bjp-15259	37	45	.	.	PUNCT
bjp-15259	38	1	material	material	NOUN
bjp-15259	38	2	and	and	CCONJ
bjp-15259	38	3	methods	method	NOUN
bjp-15259	38	4	datasets	dataset	NOUN
bjp-15259	38	5	:	:	PUNCT
bjp-15259	38	6	the	the	DET
bjp-15259	38	7	data	datum	NOUN
bjp-15259	38	8	on	on	ADP
bjp-15259	38	9	the	the	DET
bjp-15259	38	10	protein	protein	NOUN
bjp-15259	38	11	sequence	sequence	NOUN
bjp-15259	38	12	and	and	CCONJ
bjp-15259	38	13	its	its	PRON
bjp-15259	38	14	variants	variant	NOUN
bjp-15259	38	15	(	(	PUNCT
bjp-15259	38	16	single	single	ADJ
bjp-15259	38	17	amino	amino	NOUN
bjp-15259	38	18	acid	acid	NOUN
bjp-15259	38	19	polymorphisms	polymorphism	NOUN
bjp-15259	38	20	/	/	SYM
bjp-15259	38	21	missense	missense	NOUN
bjp-15259	38	22	mutations	mutation	NOUN
bjp-15259	38	23	/	/	SYM
bjp-15259	38	24	point	point	NOUN
bjp-15259	38	25	mutations	mutation	NOUN
bjp-15259	38	26	)	)	PUNCT
bjp-15259	38	27	of	of	ADP
bjp-15259	38	28	ang	ang	NOUN
bjp-15259	38	29	were	be	AUX
bjp-15259	38	30	retrieved	retrieve	VERB
bjp-15259	38	31	from	from	ADP
bjp-15259	38	32	the	the	DET
bjp-15259	38	33	swissprot	swissprot	NOUN
bjp-15259	38	34	database	database	NOUN
bjp-15259	38	35	available	available	ADJ
bjp-15259	38	36	at	at	ADP
bjp-15259	38	37	http://	http://	PROPN
bjp-15259	38	38	www.expasy.ch/sprot/.	www.expasy.ch/sprot/.	NOUN
bjp-15259	38	39	the	the	DET
bjp-15259	38	40	segments	segment	NOUN
bjp-15259	38	41	of	of	ADP
bjp-15259	38	42	every	every	DET
bjp-15259	38	43	swissprot	swissprot	NOUN
bjp-15259	38	44	entry	entry	NOUN
bjp-15259	38	45	imparted	impart	VERB
bjp-15259	38	46	details	detail	NOUN
bjp-15259	38	47	on	on	ADP
bjp-15259	38	48	polymorphic	polymorphic	ADJ
bjp-15259	38	49	variants	variant	NOUN
bjp-15259	38	50	,	,	PUNCT
bjp-15259	38	51	some	some	PRON
bjp-15259	38	52	of	of	ADP
bjp-15259	38	53	which	which	PRON
bjp-15259	38	54	were	be	AUX
bjp-15259	38	55	disease(s	disease(s	NOUN
bjp-15259	38	56	)	)	PUNCT
bjp-15259	38	57	associated	associate	VERB
bjp-15259	38	58	by	by	ADP
bjp-15259	38	59	causing	cause	VERB
bjp-15259	38	60	defects	defect	NOUN
bjp-15259	38	61	in	in	ADP
bjp-15259	38	62	a	a	DET
bjp-15259	38	63	given	give	VERB
bjp-15259	38	64	protein	protein	NOUN
bjp-15259	38	65	(	(	PUNCT
bjp-15259	38	66	yip	yip	PROPN
bjp-15259	38	67	et	et	PROPN
bjp-15259	38	68	al	al	PROPN
bjp-15259	38	69	.	.	PROPN
bjp-15259	38	70	,	,	PUNCT
bjp-15259	38	71	2004	2004	NUM
bjp-15259	38	72	,	,	PUNCT
bjp-15259	38	73	2008	2008	NUM
bjp-15259	38	74	;	;	PUNCT
bjp-15259	38	75	boeckmann	boeckmann	PROPN
bjp-15259	38	76	et	et	PROPN
bjp-15259	38	77	al	al	PROPN
bjp-15259	38	78	.	.	PROPN
bjp-15259	38	79	,	,	PUNCT
bjp-15259	38	80	2003	2003	NUM
bjp-15259	38	81	)	)	PUNCT
bjp-15259	38	82	.	.	PUNCT
bjp-15259	39	1	the	the	DET
bjp-15259	39	2	3d	3d	PROPN
bjp-15259	39	3	structure	structure	NOUN
bjp-15259	39	4	of	of	ADP
bjp-15259	39	5	angiogenin	angiogenin	NOUN
bjp-15259	39	6	and	and	CCONJ
bjp-15259	39	7	their	their	PRON
bjp-15259	39	8	complexes	complex	NOUN
bjp-15259	39	9	were	be	AUX
bjp-15259	39	10	extracted	extract	VERB
bjp-15259	39	11	from	from	ADP
bjp-15259	39	12	protein	protein	NOUN
bjp-15259	39	13	data	datum	NOUN
bjp-15259	39	14	bank	bank	PROPN
bjp-15259	39	15	with	with	ADP
bjp-15259	39	16	pdb	pdb	PROPN
bjp-15259	39	17	i	i	PROPN
bjp-15259	39	18	d	d	PROPN
bjp-15259	39	19	2ang	2ang	PROPN
bjp-15259	39	20	(	(	PUNCT
bjp-15259	39	21	berman	berman	PROPN
bjp-15259	39	22	et	et	PROPN
bjp-15259	39	23	al	al	PROPN
bjp-15259	39	24	.	.	PROPN
bjp-15259	39	25	,	,	PUNCT
bjp-15259	39	26	2000	2000	NUM
bjp-15259	39	27	)	)	PUNCT
bjp-15259	39	28	for	for	ADP
bjp-15259	39	29	mutant	mutant	ADJ
bjp-15259	39	30	modeling	modeling	NOUN
bjp-15259	39	31	and	and	CCONJ
bjp-15259	39	32	docking	dock	VERB
bjp-15259	39	33	studies	study	NOUN
bjp-15259	39	34	according	accord	VERB
bjp-15259	39	35	to	to	ADP
bjp-15259	39	36	harmful	harmful	ADJ
bjp-15259	39	37	point	point	NOUN
bjp-15259	39	38	mutants	mutant	NOUN
bjp-15259	39	39	.	.	PUNCT
bjp-15259	40	1	prediction	prediction	NOUN
bjp-15259	40	2	of	of	ADP
bjp-15259	40	3	stability	stability	NOUN
bjp-15259	40	4	changes	change	NOUN
bjp-15259	40	5	caused	cause	VERB
bjp-15259	40	6	by	by	ADP
bjp-15259	40	7	saps	sap	NOUN
bjp-15259	40	8	using	use	VERB
bjp-15259	40	9	support	support	NOUN
bjp-15259	40	10	vector	vector	NOUN
bjp-15259	40	11	machine	machine	NOUN
bjp-15259	40	12	(	(	PUNCT
bjp-15259	40	13	i	i	NOUN
bjp-15259	40	14	-	-	PUNCT
bjp-15259	40	15	mutant2.0	mutant2.0	PROPN
bjp-15259	40	16	):	):	PUNCT
bjp-15259	40	17	we	we	PRON
bjp-15259	40	18	used	use	VERB
bjp-15259	40	19	the	the	DET
bjp-15259	40	20	program	program	NOUN
bjp-15259	40	21	i	i	PRON
bjp-15259	40	22	-	-	PUNCT
bjp-15259	40	23	mutant2.0	mutant2.0	PROPN
bjp-15259	40	24	available	available	ADJ
bjp-15259	40	25	at	at	ADP
bjp-15259	40	26	http://gpcr.biocomp	http://gpcr.biocomp	PROPN
bjp-15259	40	27	.	.	PUNCT
bjp-15259	41	1	unibo.it/cgi/predictors/imutant2.0/	unibo.it/cgi/predictors/imutant2.0/	PROPN
bjp-15259	41	2	i	i	PROPN
bjp-15259	41	3	-	-	PUNCT
bjp-15259	41	4	mutant2.0	mutant2.0	PROPN
bjp-15259	41	5	.	.	PUNCT
bjp-15259	42	1	cgi	cgi	PROPN
bjp-15259	42	2	.	.	PUNCT
bjp-15259	43	1	i	i	PRON
bjp-15259	43	2	-mutant2.0	-mutant2.0	PROPN
bjp-15259	43	3	,	,	PUNCT
bjp-15259	43	4	a	a	DET
bjp-15259	43	5	support	support	NOUN
bjp-15259	43	6	vector	vector	NOUN
bjp-15259	43	7	machine	machine	NOUN
bjp-15259	43	8	(	(	PUNCT
bjp-15259	43	9	smv	smv	NOUN
bjp-15259	43	10	)	)	PUNCT
bjp-15259	43	11	based	base	VERB
bjp-15259	43	12	tool	tool	NOUN
bjp-15259	43	13	worked	work	VERB
bjp-15259	43	14	out	out	ADP
bjp-15259	43	15	the	the	DET
bjp-15259	43	16	automatic	automatic	ADJ
bjp-15259	43	17	prediction	prediction	NOUN
bjp-15259	43	18	of	of	ADP
bjp-15259	43	19	protein	protein	NOUN
bjp-15259	43	20	stability	stability	NOUN
bjp-15259	43	21	change	change	VERB
bjp-15259	43	22	upon	upon	SCONJ
bjp-15259	43	23	single	single	ADJ
bjp-15259	43	24	amino	amino	NOUN
bjp-15259	43	25	acid	acid	NOUN
bjp-15259	43	26	substitution	substitution	NOUN
bjp-15259	43	27	.	.	PUNCT
bjp-15259	44	1	starting	start	VERB
bjp-15259	44	2	either	either	CCONJ
bjp-15259	44	3	from	from	ADP
bjp-15259	44	4	the	the	DET
bjp-15259	44	5	protein	protein	NOUN
bjp-15259	44	6	structure	structure	NOUN
bjp-15259	44	7	or	or	CCONJ
bjp-15259	44	8	from	from	ADP
bjp-15259	44	9	the	the	DET
bjp-15259	44	10	protein	protein	NOUN
bjp-15259	44	11	sequence	sequence	NOUN
bjp-15259	44	12	,	,	PUNCT
bjp-15259	44	13	the	the	DET
bjp-15259	44	14	predictions	prediction	NOUN
bjp-15259	44	15	were	be	AUX
bjp-15259	44	16	done	do	VERB
bjp-15259	44	17	through	through	ADP
bjp-15259	44	18	imutant2.0	imutant2.0	PROPN
bjp-15259	44	19	(	(	PUNCT
bjp-15259	44	20	capriotti	capriotti	NOUN
bjp-15259	44	21	et	et	PROPN
bjp-15259	44	22	al	al	PROPN
bjp-15259	44	23	.	.	PROPN
bjp-15259	44	24	,	,	PUNCT
bjp-15259	44	25	2005	2005	NUM
bjp-15259	44	26	)	)	PUNCT
bjp-15259	44	27	.	.	PUNCT
bjp-15259	45	1	here	here	ADV
bjp-15259	45	2	,	,	PUNCT
bjp-15259	45	3	a	a	DET
bjp-15259	45	4	data	datum	NOUN
bjp-15259	45	5	set	set	VERB
bjp-15259	45	6	used	use	VERB
bjp-15259	45	7	derived	derive	VERB
bjp-15259	45	8	from	from	ADP
bjp-15259	45	9	protherm	protherm	PROPN
bjp-15259	45	10	(	(	PUNCT
bjp-15259	45	11	bava	bava	PROPN
bjp-15259	45	12	et	et	PROPN
bjp-15259	45	13	al	al	PROPN
bjp-15259	45	14	.	.	PROPN
bjp-15259	45	15	,	,	PUNCT
bjp-15259	45	16	2004	2004	NUM
bjp-15259	45	17	)	)	PUNCT
bjp-15259	45	18	is	be	AUX
bjp-15259	45	19	the	the	DET
bjp-15259	45	20	database	database	NOUN
bjp-15259	45	21	considered	consider	VERB
bjp-15259	45	22	when	when	SCONJ
bjp-15259	45	23	compared	compare	VERB
bjp-15259	45	24	against	against	ADP
bjp-15259	45	25	others	other	NOUN
bjp-15259	45	26	for	for	ADP
bjp-15259	45	27	thermodynamic	thermodynamic	ADJ
bjp-15259	45	28	experimental	experimental	ADJ
bjp-15259	45	29	data	datum	NOUN
bjp-15259	45	30	of	of	ADP
bjp-15259	45	31	free	free	ADJ
bjp-15259	45	32	energy	energy	NOUN
bjp-15259	45	33	changes	change	NOUN
bjp-15259	45	34	concerning	concern	VERB
bjp-15259	45	35	protein	protein	NOUN
bjp-15259	45	36	stability	stability	NOUN
bjp-15259	45	37	caused	cause	VERB
bjp-15259	45	38	by	by	ADP
bjp-15259	45	39	mutations	mutation	NOUN
bjp-15259	45	40	in	in	ADP
bjp-15259	45	41	various	various	ADJ
bjp-15259	45	42	environment	environment	NOUN
bjp-15259	45	43	.	.	PUNCT
bjp-15259	46	1	the	the	DET
bjp-15259	46	2	output	output	NOUN
bjp-15259	46	3	files	file	NOUN
bjp-15259	46	4	indicated	indicate	VERB
bjp-15259	46	5	the	the	DET
bjp-15259	46	6	predicted	predict	VERB
bjp-15259	46	7	free	free	ADJ
bjp-15259	46	8	energy	energy	NOUN
bjp-15259	46	9	change	change	NOUN
bjp-15259	46	10	value	value	NOUN
bjp-15259	46	11	or	or	CCONJ
bjp-15259	46	12	sign	sign	NOUN
bjp-15259	46	13	(	(	PUNCT
bjp-15259	46	14	∆∆g	∆∆g	PROPN
bjp-15259	46	15	)	)	PUNCT
bjp-15259	46	16	,	,	PUNCT
bjp-15259	46	17	which	which	PRON
bjp-15259	46	18	was	be	AUX
bjp-15259	46	19	based	base	VERB
bjp-15259	46	20	on	on	ADP
bjp-15259	46	21	the	the	DET
bjp-15259	46	22	calculation	calculation	NOUN
bjp-15259	46	23	,	,	PUNCT
bjp-15259	46	24	the	the	DET
bjp-15259	46	25	unfolding	unfold	VERB
bjp-15259	46	26	gibbs	gibbs	PROPN
bjp-15259	46	27	free	free	ADJ
bjp-15259	46	28	energy	energy	NOUN
bjp-15259	46	29	value	value	NOUN
bjp-15259	46	30	of	of	ADP
bjp-15259	46	31	the	the	DET
bjp-15259	46	32	mutated	mutate	VERB
bjp-15259	46	33	protein	protein	NOUN
bjp-15259	46	34	minus	minus	ADP
bjp-15259	46	35	the	the	DET
bjp-15259	46	36	unfolding	unfold	VERB
bjp-15259	46	37	gibbs	gibbs	PROPN
bjp-15259	46	38	free	free	ADJ
bjp-15259	46	39	energy	energy	NOUN
bjp-15259	46	40	value	value	NOUN
bjp-15259	46	41	of	of	ADP
bjp-15259	46	42	the	the	DET
bjp-15259	46	43	native	native	ADJ
bjp-15259	46	44	protein	protein	NOUN
bjp-15259	46	45	(	(	PUNCT
bjp-15259	46	46	kcal	kcal	PROPN
bjp-15259	46	47	/	/	SYM
bjp-15259	46	48	mol	mol	NOUN
bjp-15259	46	49	)	)	PUNCT
bjp-15259	46	50	.	.	PUNCT
bjp-15259	47	1	positive	positive	ADJ
bjp-15259	47	2	∆∆g	∆∆g	NOUN
bjp-15259	47	3	values	value	NOUN
bjp-15259	47	4	indicated	indicate	VERB
bjp-15259	47	5	high	high	ADJ
bjp-15259	47	6	stability	stability	NOUN
bjp-15259	47	7	for	for	ADP
bjp-15259	47	8	mutated	mutate	VERB
bjp-15259	47	9	protein	protein	NOUN
bjp-15259	47	10	and	and	CCONJ
bjp-15259	47	11	negative	negative	ADJ
bjp-15259	47	12	values	value	NOUN
bjp-15259	47	13	meant	mean	VERB
bjp-15259	47	14	a	a	DET
bjp-15259	47	15	low	low	ADJ
bjp-15259	47	16	stability	stability	NOUN
bjp-15259	47	17	.	.	PUNCT
bjp-15259	48	1	analysis	analysis	NOUN
bjp-15259	48	2	of	of	ADP
bjp-15259	48	3	functional	functional	ADJ
bjp-15259	48	4	effects	effect	NOUN
bjp-15259	48	5	of	of	ADP
bjp-15259	48	6	saps	sap	NOUN
bjp-15259	48	7	by	by	ADP
bjp-15259	48	8	a	a	DET
bjp-15259	48	9	sequence	sequence	NOUN
bjp-15259	48	10	homology	homology	NOUN
bjp-15259	48	11	-	-	PUNCT
bjp-15259	48	12	based	base	VERB
bjp-15259	48	13	method	method	NOUN
bjp-15259	48	14	(	(	PUNCT
bjp-15259	48	15	sift	sift	ADJ
bjp-15259	48	16	):	):	PUNCT
bjp-15259	48	17	the	the	DET
bjp-15259	48	18	program	program	NOUN
bjp-15259	48	19	sift	sift	NOUN
bjp-15259	48	20	(	(	PUNCT
bjp-15259	48	21	ng	ng	PROPN
bjp-15259	48	22	et	et	PROPN
bjp-15259	48	23	al	al	PROPN
bjp-15259	48	24	.	.	PROPN
bjp-15259	48	25	,	,	PUNCT
bjp-15259	48	26	2003	2003	NUM
bjp-15259	48	27	)	)	PUNCT
bjp-15259	48	28	available	available	ADJ
bjp-15259	48	29	at	at	ADP
bjp-15259	48	30	http://blocks.fhcrc.org/sift/	http://blocks.fhcrc.org/sift/	ADJ
bjp-15259	48	31	sift.html	sift.html	NOUN
bjp-15259	48	32	was	be	AUX
bjp-15259	48	33	employed	employ	VERB
bjp-15259	48	34	,	,	PUNCT
bjp-15259	48	35	which	which	PRON
bjp-15259	48	36	specifically	specifically	ADV
bjp-15259	48	37	gives	give	VERB
bjp-15259	48	38	an	an	DET
bjp-15259	48	39	unprecedented	unprecedented	ADJ
bjp-15259	48	40	level	level	NOUN
bjp-15259	48	41	of	of	ADP
bjp-15259	48	42	control	control	NOUN
bjp-15259	48	43	required	require	VERB
bjp-15259	48	44	to	to	PART
bjp-15259	48	45	identify	identify	VERB
bjp-15259	48	46	deleterious	deleterious	ADJ
bjp-15259	48	47	single	single	ADJ
bjp-15259	48	48	amino	amino	NOUN
bjp-15259	48	49	acid	acid	NOUN
bjp-15259	48	50	polymorphisms	polymorphism	NOUN
bjp-15259	48	51	.	.	PUNCT
bjp-15259	49	1	sift	sift	PROPN
bjp-15259	49	2	,	,	PUNCT
bjp-15259	49	3	a	a	DET
bjp-15259	49	4	sequence	sequence	NOUN
bjp-15259	49	5	homology	homology	NOUN
bjp-15259	49	6	-	-	PUNCT
bjp-15259	49	7	based	base	VERB
bjp-15259	49	8	tool	tool	NOUN
bjp-15259	49	9	postulates	postulate	VERB
bjp-15259	49	10	the	the	DET
bjp-15259	49	11	conservation	conservation	NOUN
bjp-15259	49	12	of	of	ADP
bjp-15259	49	13	essential	essential	ADJ
bjp-15259	49	14	amino	amino	ADJ
bjp-15259	49	15	acids	acid	NOUN
bjp-15259	49	16	in	in	ADP
bjp-15259	49	17	a	a	DET
bjp-15259	49	18	family	family	NOUN
bjp-15259	49	19	of	of	ADP
bjp-15259	49	20	protein	protein	NOUN
bjp-15259	49	21	;	;	PUNCT
bjp-15259	49	22	therefore	therefore	ADV
bjp-15259	49	23	,	,	PUNCT
bjp-15259	49	24	mutations	mutation	NOUN
bjp-15259	49	25	at	at	ADP
bjp-15259	49	26	well	well	ADV
bjp-15259	49	27	-	-	PUNCT
bjp-15259	49	28	conserved	conserve	VERB
bjp-15259	49	29	locales	locale	NOUN
bjp-15259	49	30	have	have	VERB
bjp-15259	49	31	a	a	DET
bjp-15259	49	32	tendency	tendency	NOUN
bjp-15259	49	33	to	to	PART
bjp-15259	49	34	be	be	AUX
bjp-15259	49	35	deleterious	deleterious	ADJ
bjp-15259	49	36	(	(	PUNCT
bjp-15259	49	37	ng	ng	PROPN
bjp-15259	49	38	et	et	PROPN
bjp-15259	49	39	al	al	PROPN
bjp-15259	49	40	.	.	PROPN
bjp-15259	49	41	,	,	PUNCT
bjp-15259	49	42	2001	2001	NUM
bjp-15259	49	43	)	)	PUNCT
bjp-15259	49	44	.	.	PUNCT
bjp-15259	50	1	queries	query	NOUN
bjp-15259	50	2	are	be	AUX
bjp-15259	50	3	submitted	submit	VERB
bjp-15259	50	4	in	in	ADP
bjp-15259	50	5	the	the	DET
bjp-15259	50	6	sequence	sequence	NOUN
bjp-15259	50	7	format	format	NOUN
bjp-15259	50	8	for	for	ADP
bjp-15259	50	9	proteins	protein	NOUN
bjp-15259	50	10	.	.	PUNCT
bjp-15259	51	1	once	once	SCONJ
bjp-15259	51	2	the	the	DET
bjp-15259	51	3	query	query	NOUN
bjp-15259	51	4	sequences	sequence	NOUN
bjp-15259	51	5	are	be	AUX
bjp-15259	51	6	loaded	load	VERB
bjp-15259	51	7	in	in	ADP
bjp-15259	51	8	sift	sift	NOUN
bjp-15259	51	9	,	,	PUNCT
bjp-15259	51	10	they	they	PRON
bjp-15259	51	11	can	can	AUX
bjp-15259	51	12	be	be	AUX
bjp-15259	51	13	used	use	VERB
bjp-15259	51	14	to	to	PART
bjp-15259	51	15	generate	generate	VERB
bjp-15259	51	16	a	a	DET
bjp-15259	51	17	multiple	multiple	ADJ
bjp-15259	51	18	sequence	sequence	NOUN
bjp-15259	51	19	alignment	alignment	NOUN
bjp-15259	51	20	from	from	ADP
bjp-15259	51	21	which	which	PRON
bjp-15259	51	22	the	the	DET
bjp-15259	51	23	tolerated	tolerate	VERB
bjp-15259	51	24	and	and	CCONJ
bjp-15259	51	25	deleterious	deleterious	ADJ
bjp-15259	51	26	substitutions	substitution	NOUN
bjp-15259	51	27	are	be	AUX
bjp-15259	51	28	predicted	predict	VERB
bjp-15259	51	29	for	for	ADP
bjp-15259	51	30	every	every	DET
bjp-15259	51	31	position	position	NOUN
bjp-15259	51	32	of	of	ADP
bjp-15259	51	33	the	the	DET
bjp-15259	51	34	query	query	NOUN
bjp-15259	51	35	sequence	sequence	NOUN
bjp-15259	51	36	.	.	PUNCT
bjp-15259	52	1	substitutions	substitution	NOUN
bjp-15259	52	2	at	at	ADP
bjp-15259	52	3	each	each	DET
bjp-15259	52	4	position	position	NOUN
bjp-15259	52	5	with	with	ADP
bjp-15259	52	6	normalized	normalize	VERB
bjp-15259	52	7	probabilities	probability	NOUN
bjp-15259	52	8	less	less	ADJ
bjp-15259	52	9	than	than	ADP
bjp-15259	52	10	a	a	DET
bjp-15259	52	11	chosen	choose	VERB
bjp-15259	52	12	cutoff	cutoff	NOUN
bjp-15259	52	13	were	be	AUX
bjp-15259	52	14	predicted	predict	VERB
bjp-15259	52	15	to	to	PART
bjp-15259	52	16	be	be	AUX
bjp-15259	52	17	deleterious	deleterious	ADJ
bjp-15259	52	18	and	and	CCONJ
bjp-15259	52	19	those	those	PRON
bjp-15259	52	20	greater	great	ADJ
bjp-15259	52	21	than	than	ADP
bjp-15259	52	22	or	or	CCONJ
bjp-15259	52	23	equal	equal	ADJ
bjp-15259	52	24	to	to	ADP
bjp-15259	52	25	the	the	DET
bjp-15259	52	26	cutoff	cutoff	NOUN
bjp-15259	52	27	are	be	AUX
bjp-15259	52	28	predicted	predict	VERB
bjp-15259	52	29	to	to	PART
bjp-15259	52	30	be	be	AUX
bjp-15259	52	31	tolerated	tolerate	VERB
bjp-15259	52	32	(	(	PUNCT
bjp-15259	52	33	ng	ng	PROPN
bjp-15259	52	34	et	et	PROPN
bjp-15259	52	35	al	al	PROPN
bjp-15259	52	36	.	.	PROPN
bjp-15259	52	37	,	,	PUNCT
bjp-15259	52	38	2003	2003	NUM
bjp-15259	52	39	)	)	PUNCT
bjp-15259	52	40	.	.	PUNCT
bjp-15259	53	1	the	the	DET
bjp-15259	53	2	cutoff	cutoff	NOUN
bjp-15259	53	3	value	value	NOUN
bjp-15259	53	4	in	in	ADP
bjp-15259	53	5	sift	sift	PROPN
bjp-15259	53	6	program	program	NOUN
bjp-15259	53	7	was	be	AUX
bjp-15259	53	8	tolerance	tolerance	NOUN
bjp-15259	53	9	index	index	NOUN
bjp-15259	53	10	of	of	ADP
bjp-15259	53	11	≥0.05	≥0.05	PROPN
bjp-15259	53	12	.	.	PUNCT
bjp-15259	54	1	the	the	PRON
bjp-15259	54	2	higher	high	ADJ
bjp-15259	54	3	the	the	DET
bjp-15259	54	4	tolerance	tolerance	NOUN
bjp-15259	54	5	index	index	NOUN
bjp-15259	54	6	,	,	PUNCT
bjp-15259	54	7	the	the	DET
bjp-15259	54	8	less	less	ADV
bjp-15259	54	9	functional	functional	ADJ
bjp-15259	54	10	impact	impact	NOUN
bjp-15259	54	11	a	a	DET
bjp-15259	54	12	particular	particular	ADJ
bjp-15259	54	13	amino	amino	NOUN
bjp-15259	54	14	acid	acid	NOUN
bjp-15259	54	15	substitution	substitution	NOUN
bjp-15259	54	16	would	would	AUX
bjp-15259	54	17	be	be	AUX
bjp-15259	54	18	likely	likely	ADJ
bjp-15259	54	19	to	to	PART
bjp-15259	54	20	have	have	VERB
bjp-15259	54	21	.	.	PUNCT
bjp-15259	55	1	simulation	simulation	NOUN
bjp-15259	55	2	for	for	ADP
bjp-15259	55	3	functional	functional	ADJ
bjp-15259	55	4	effects	effect	NOUN
bjp-15259	55	5	in	in	ADP
bjp-15259	55	6	saps	sap	NOUN
bjp-15259	55	7	by	by	ADP
bjp-15259	55	8	structure	structure	NOUN
bjp-15259	55	9	homology	homology	NOUN
bjp-15259	55	10	based	base	VERB
bjp-15259	55	11	method	method	NOUN
bjp-15259	55	12	(	(	PUNCT
bjp-15259	55	13	polyphen	polyphen	ADV
bjp-15259	55	14	):	):	PUNCT
bjp-15259	55	15	analyzing	analyze	VERB
bjp-15259	55	16	the	the	DET
bjp-15259	55	17	damage	damage	NOUN
bjp-15259	55	18	caused	cause	VERB
bjp-15259	55	19	by	by	ADP
bjp-15259	55	20	point	point	NOUN
bjp-15259	55	21	mutations	mutation	NOUN
bjp-15259	55	22	at	at	ADP
bjp-15259	55	23	the	the	DET
bjp-15259	55	24	structural	structural	ADJ
bjp-15259	55	25	level	level	NOUN
bjp-15259	55	26	was	be	AUX
bjp-15259	55	27	considered	consider	VERB
bjp-15259	55	28	very	very	ADV
bjp-15259	55	29	important	important	ADJ
bjp-15259	55	30	to	to	PART
bjp-15259	55	31	understand	understand	VERB
bjp-15259	55	32	the	the	DET
bjp-15259	55	33	functional	functional	ADJ
bjp-15259	55	34	activity	activity	NOUN
bjp-15259	55	35	of	of	ADP
bjp-15259	55	36	the	the	DET
bjp-15259	55	37	protein	protein	NOUN
bjp-15259	55	38	.	.	PUNCT
bjp-15259	56	1	in	in	ADP
bjp-15259	56	2	order	order	NOUN
bjp-15259	56	3	to	to	PART
bjp-15259	56	4	focus	focus	VERB
bjp-15259	56	5	this	this	DET
bjp-15259	56	6	issue	issue	NOUN
bjp-15259	56	7	,	,	PUNCT
bjp-15259	56	8	we	we	PRON
bjp-15259	56	9	used	use	VERB
bjp-15259	56	10	the	the	DET
bjp-15259	56	11	server	server	NOUN
bjp-15259	56	12	polyphen	polyphen	ADV
bjp-15259	56	13	(	(	PUNCT
bjp-15259	56	14	ramensky	ramensky	PROPN
bjp-15259	56	15	et	et	PROPN
bjp-15259	56	16	al	al	PROPN
bjp-15259	56	17	.	.	PROPN
bjp-15259	56	18	,	,	PUNCT
bjp-15259	56	19	2002	2002	NUM
bjp-15259	56	20	)	)	PUNCT
bjp-15259	56	21	,	,	PUNCT
bjp-15259	56	22	available	available	ADJ
bjp-15259	56	23	at	at	ADP
bjp-15259	56	24	http://coot.embl.de/polyphen/.	http://coot.embl.de/polyphen/.	PROPN
bjp-15259	56	25	we	we	PRON
bjp-15259	56	26	parameterized	parameterize	VERB
bjp-15259	56	27	the	the	DET
bjp-15259	56	28	protein	protein	NOUN
bjp-15259	56	29	sequence	sequence	NOUN
bjp-15259	56	30	,	,	PUNCT
bjp-15259	56	31	swall	swall	NOUN
bjp-15259	56	32	database	database	VERB
bjp-15259	56	33	i	i	PROPN
bjp-15259	56	34	d	d	PROPN
bjp-15259	56	35	or	or	CCONJ
bjp-15259	56	36	accession	accession	NOUN
bjp-15259	56	37	number	number	NOUN
bjp-15259	56	38	,	,	PUNCT
bjp-15259	56	39	together	together	ADV
bjp-15259	56	40	with	with	ADP
bjp-15259	56	41	the	the	DET
bjp-15259	56	42	sequence	sequence	NOUN
bjp-15259	56	43	position	position	NOUN
bjp-15259	56	44	of	of	ADP
bjp-15259	56	45	two	two	NUM
bjp-15259	56	46	amino	amino	NOUN
bjp-15259	56	47	acid	acid	NOUN
bjp-15259	56	48	variants	variant	NOUN
bjp-15259	56	49	as	as	ADP
bjp-15259	56	50	input	input	NOUN
bjp-15259	56	51	options	option	NOUN
bjp-15259	56	52	for	for	ADP
bjp-15259	56	53	the	the	DET
bjp-15259	56	54	polyphen	polyphen	ADJ
bjp-15259	56	55	server	server	NOUN
bjp-15259	56	56	.	.	PUNCT
bjp-15259	57	1	the	the	DET
bjp-15259	57	2	query	query	NOUN
bjp-15259	57	3	was	be	AUX
bjp-15259	57	4	submitted	submit	VERB
bjp-15259	57	5	in	in	ADP
bjp-15259	57	6	the	the	DET
bjp-15259	57	7	sequence	sequence	NOUN
bjp-15259	57	8	format	format	NOUN
bjp-15259	57	9	for	for	ADP
bjp-15259	57	10	a	a	DET
bjp-15259	57	11	protein	protein	NOUN
bjp-15259	57	12	with	with	ADP
bjp-15259	57	13	a	a	DET
bjp-15259	57	14	mutational	mutational	ADJ
bjp-15259	57	15	position	position	NOUN
bjp-15259	57	16	and	and	CCONJ
bjp-15259	57	17	two	two	NUM
bjp-15259	57	18	amino	amino	ADJ
bjp-15259	57	19	acid	acid	NOUN
bjp-15259	57	20	variants	variant	NOUN
bjp-15259	57	21	.	.	PUNCT
bjp-15259	58	1	in	in	ADP
bjp-15259	58	2	order	order	NOUN
bjp-15259	58	3	to	to	PART
bjp-15259	58	4	calculate	calculate	VERB
bjp-15259	58	5	bangladesh	bangladesh	PROPN
bjp-15259	58	6	j	j	PROPN
bjp-15259	58	7	pharmacol	pharmacol	PROPN
bjp-15259	58	8	2013	2013	NUM
bjp-15259	58	9	;	;	PUNCT
bjp-15259	58	10	8	8	NUM
bjp-15259	58	11	:	:	PUNCT
bjp-15259	58	12	382	382	NUM
bjp-15259	58	13	-	-	SYM
bjp-15259	58	14	389	389	NUM
bjp-15259	58	15	383	383	NUM
bjp-15259	58	16	the	the	DET
bjp-15259	58	17	score	score	NOUN
bjp-15259	58	18	,	,	PUNCT
bjp-15259	58	19	polyphen	polyphen	ADJ
bjp-15259	58	20	server	server	NOUN
bjp-15259	58	21	employed	employ	VERB
bjp-15259	58	22	the	the	DET
bjp-15259	58	23	sequencebased	sequencebase	VERB
bjp-15259	58	24	characterization	characterization	NOUN
bjp-15259	58	25	of	of	ADP
bjp-15259	58	26	the	the	DET
bjp-15259	58	27	substitution	substitution	NOUN
bjp-15259	58	28	site	site	NOUN
bjp-15259	58	29	,	,	PUNCT
bjp-15259	58	30	profile	profile	VERB
bjp-15259	58	31	analysis	analysis	NOUN
bjp-15259	58	32	of	of	ADP
bjp-15259	58	33	homologous	homologous	ADJ
bjp-15259	58	34	sequences	sequence	NOUN
bjp-15259	58	35	,	,	PUNCT
bjp-15259	58	36	and	and	CCONJ
bjp-15259	58	37	mapping	mapping	NOUN
bjp-15259	58	38	of	of	ADP
bjp-15259	58	39	the	the	DET
bjp-15259	58	40	substitution	substitution	NOUN
bjp-15259	58	41	site	site	NOUN
bjp-15259	58	42	to	to	ADP
bjp-15259	58	43	known	know	VERB
bjp-15259	58	44	protein	protein	NOUN
bjp-15259	58	45	3d	3d	NUM
bjp-15259	58	46	structures	structure	NOUN
bjp-15259	58	47	.	.	PUNCT
bjp-15259	59	1	the	the	DET
bjp-15259	59	2	position	position	NOUN
bjp-15259	59	3	-	-	PUNCT
bjp-15259	59	4	specific	specific	ADJ
bjp-15259	59	5	independent	independent	ADJ
bjp-15259	59	6	counts	count	NOUN
bjp-15259	59	7	(	(	PUNCT
bjp-15259	59	8	psic	psic	ADJ
bjp-15259	59	9	)	)	PUNCT
bjp-15259	59	10	scores	score	NOUN
bjp-15259	59	11	were	be	AUX
bjp-15259	59	12	calculated	calculate	VERB
bjp-15259	59	13	for	for	ADP
bjp-15259	59	14	every	every	DET
bjp-15259	59	15	two	two	NUM
bjp-15259	59	16	variants	variant	NOUN
bjp-15259	59	17	,	,	PUNCT
bjp-15259	59	18	followed	follow	VERB
bjp-15259	59	19	by	by	ADP
bjp-15259	59	20	computing	compute	VERB
bjp-15259	59	21	the	the	DET
bjp-15259	59	22	psic	psic	ADJ
bjp-15259	59	23	score	score	NOUN
bjp-15259	59	24	variation	variation	NOUN
bjp-15259	59	25	amid	amid	ADP
bjp-15259	59	26	them	they	PRON
bjp-15259	59	27	.	.	PUNCT
bjp-15259	60	1	the	the	PRON
bjp-15259	60	2	higher	high	ADJ
bjp-15259	60	3	the	the	DET
bjp-15259	60	4	psic	psic	ADJ
bjp-15259	60	5	score	score	NOUN
bjp-15259	60	6	difference	difference	NOUN
bjp-15259	60	7	,	,	PUNCT
bjp-15259	60	8	the	the	DET
bjp-15259	60	9	greater	great	ADJ
bjp-15259	60	10	being	be	AUX
bjp-15259	60	11	the	the	DET
bjp-15259	60	12	functional	functional	ADJ
bjp-15259	60	13	impact	impact	NOUN
bjp-15259	60	14	of	of	ADP
bjp-15259	60	15	a	a	DET
bjp-15259	60	16	particular	particular	ADJ
bjp-15259	60	17	amino	amino	NOUN
bjp-15259	60	18	acid	acid	NOUN
bjp-15259	60	19	substitution	substitution	NOUN
bjp-15259	60	20	.	.	PUNCT
bjp-15259	61	1	computing	compute	VERB
bjp-15259	61	2	total	total	ADJ
bjp-15259	61	3	energy	energy	NOUN
bjp-15259	61	4	and	and	CCONJ
bjp-15259	61	5	rmsd	rmsd	VERB
bjp-15259	61	6	by	by	ADP
bjp-15259	61	7	modeling	model	VERB
bjp-15259	61	8	sap	sap	PROPN
bjp-15259	61	9	location	location	NOUN
bjp-15259	61	10	on	on	ADP
bjp-15259	61	11	protein	protein	NOUN
bjp-15259	61	12	3d	3d	NOUN
bjp-15259	61	13	structure	structure	NOUN
bjp-15259	61	14	:	:	PUNCT
bjp-15259	61	15	in	in	ADP
bjp-15259	61	16	order	order	NOUN
bjp-15259	61	17	to	to	PART
bjp-15259	61	18	compute	compute	VERB
bjp-15259	61	19	the	the	DET
bjp-15259	61	20	total	total	ADJ
bjp-15259	61	21	energy	energy	NOUN
bjp-15259	61	22	and	and	CCONJ
bjp-15259	61	23	to	to	PART
bjp-15259	61	24	evaluate	evaluate	VERB
bjp-15259	61	25	the	the	DET
bjp-15259	61	26	structural	structural	ADJ
bjp-15259	61	27	divergence	divergence	NOUN
bjp-15259	61	28	between	between	ADP
bjp-15259	61	29	the	the	DET
bjp-15259	61	30	native	native	ADJ
bjp-15259	61	31	type	type	NOUN
bjp-15259	61	32	and	and	CCONJ
bjp-15259	61	33	mutant	mutant	ADJ
bjp-15259	61	34	types	type	NOUN
bjp-15259	61	35	by	by	ADP
bjp-15259	61	36	rmsd	rmsd	NOUN
bjp-15259	61	37	(	(	PUNCT
bjp-15259	61	38	root	root	NOUN
bjp-15259	61	39	mean	mean	ADJ
bjp-15259	61	40	square	square	ADJ
bjp-15259	61	41	deviation	deviation	NOUN
bjp-15259	61	42	)	)	PUNCT
bjp-15259	61	43	,	,	PUNCT
bjp-15259	61	44	the	the	DET
bjp-15259	61	45	structural	structural	ADJ
bjp-15259	61	46	analysis	analysis	NOUN
bjp-15259	61	47	was	be	AUX
bjp-15259	61	48	executed	execute	VERB
bjp-15259	61	49	.	.	PUNCT
bjp-15259	62	1	protein	protein	NOUN
bjp-15259	62	2	data	data	PROPN
bjp-15259	62	3	bank	bank	PROPN
bjp-15259	62	4	(	(	PUNCT
bjp-15259	62	5	15	15	NUM
bjp-15259	62	6	)	)	PUNCT
bjp-15259	62	7	and	and	CCONJ
bjp-15259	62	8	single	single	ADJ
bjp-15259	62	9	amino	amino	NOUN
bjp-15259	62	10	acid	acid	NOUN
bjp-15259	62	11	polymorphism	polymorphism	NOUN
bjp-15259	62	12	database	database	NOUN
bjp-15259	62	13	(	(	PUNCT
bjp-15259	62	14	saapdb	saapdb	ADJ
bjp-15259	62	15	)	)	PUNCT
bjp-15259	62	16	(	(	PUNCT
bjp-15259	62	17	cavallo	cavallo	NOUN
bjp-15259	62	18	et	et	NOUN
bjp-15259	62	19	al	al	PROPN
bjp-15259	62	20	.	.	PROPN
bjp-15259	62	21	,	,	PUNCT
bjp-15259	62	22	2005	2005	NUM
bjp-15259	62	23	)	)	PUNCT
bjp-15259	62	24	were	be	AUX
bjp-15259	62	25	employed	employ	VERB
bjp-15259	62	26	for	for	ADP
bjp-15259	62	27	finding	find	VERB
bjp-15259	62	28	the	the	DET
bjp-15259	62	29	angiogenin	angiogenin	NOUN
bjp-15259	62	30	protein	protein	NOUN
bjp-15259	62	31	(	(	PUNCT
bjp-15259	62	32	pdb	pdb	PROPN
bjp-15259	62	33	i	i	PROPN
bjp-15259	62	34	d	d	PROPN
bjp-15259	62	35	:	:	PUNCT
bjp-15259	62	36	2ang	2ang	NUM
bjp-15259	62	37	)	)	PUNCT
bjp-15259	62	38	3d	3d	NUM
bjp-15259	62	39	structure	structure	NOUN
bjp-15259	62	40	.	.	PUNCT
bjp-15259	63	1	also	also	ADV
bjp-15259	63	2	the	the	DET
bjp-15259	63	3	position	position	NOUN
bjp-15259	63	4	of	of	ADP
bjp-15259	63	5	mutation	mutation	NOUN
bjp-15259	63	6	and	and	CCONJ
bjp-15259	63	7	the	the	DET
bjp-15259	63	8	mutated	mutate	VERB
bjp-15259	63	9	residue	residue	NOUN
bjp-15259	63	10	in	in	ADP
bjp-15259	63	11	pdb	pdb	PROPN
bjp-15259	63	12	i	i	PROPN
bjp-15259	63	13	d	d	PROPN
bjp-15259	63	14	2ang	2ang	PROPN
bjp-15259	63	15	was	be	AUX
bjp-15259	63	16	checked	check	VERB
bjp-15259	63	17	out	out	ADP
bjp-15259	63	18	.	.	PUNCT
bjp-15259	64	1	swisspdb	swisspdb	PROPN
bjp-15259	64	2	viewer	viewer	PROPN
bjp-15259	64	3	brought	bring	VERB
bjp-15259	64	4	about	about	ADP
bjp-15259	64	5	the	the	DET
bjp-15259	64	6	mutation	mutation	NOUN
bjp-15259	64	7	and	and	CCONJ
bjp-15259	64	8	nomad	nomad	ADJ
bjp-15259	64	9	-	-	PUNCT
bjp-15259	64	10	ref	ref	NOUN
bjp-15259	64	11	server	server	NOUN
bjp-15259	64	12	executed	execute	VERB
bjp-15259	64	13	the	the	DET
bjp-15259	64	14	energy	energy	NOUN
bjp-15259	64	15	minimization	minimization	NOUN
bjp-15259	64	16	for	for	ADP
bjp-15259	64	17	3d	3d	PROPN
bjp-15259	64	18	structures	structure	NOUN
bjp-15259	64	19	(	(	PUNCT
bjp-15259	64	20	lindahl	lindahl	PROPN
bjp-15259	64	21	et	et	NOUN
bjp-15259	64	22	al	al	PROPN
bjp-15259	64	23	.	.	PROPN
bjp-15259	64	24	,	,	PUNCT
bjp-15259	64	25	2006	2006	NUM
bjp-15259	64	26	)	)	PUNCT
bjp-15259	64	27	.	.	PUNCT
bjp-15259	65	1	depending	depend	VERB
bjp-15259	65	2	on	on	ADP
bjp-15259	65	3	the	the	DET
bjp-15259	65	4	system	system	NOUN
bjp-15259	65	5	of	of	ADP
bjp-15259	65	6	steepest	steep	ADJ
bjp-15259	65	7	descent	descent	NOUN
bjp-15259	65	8	,	,	PUNCT
bjp-15259	65	9	conjugate	conjugate	ADJ
bjp-15259	65	10	gradient	gradient	NOUN
bjp-15259	65	11	and	and	CCONJ
bjp-15259	65	12	l	l	NOUN
bjp-15259	65	13	-	-	ADJ
bjp-15259	65	14	bfgs	bfgs	ADJ
bjp-15259	65	15	(	(	PUNCT
bjp-15259	65	16	delarue	delarue	PROPN
bjp-15259	65	17	et	et	PROPN
bjp-15259	65	18	al	al	PROPN
bjp-15259	65	19	.	.	PROPN
bjp-15259	65	20	,	,	PUNCT
bjp-15259	65	21	2004	2004	NUM
bjp-15259	65	22	)	)	PUNCT
bjp-15259	65	23	,	,	PUNCT
bjp-15259	65	24	this	this	DET
bjp-15259	65	25	server	server	NOUN
bjp-15259	65	26	was	be	AUX
bjp-15259	65	27	carried	carry	VERB
bjp-15259	65	28	out	out	ADP
bjp-15259	65	29	with	with	ADP
bjp-15259	65	30	gromacs	gromacs	NOUN
bjp-15259	65	31	as	as	ADP
bjp-15259	65	32	default	default	NOUN
bjp-15259	65	33	force	force	NOUN
bjp-15259	65	34	field	field	NOUN
bjp-15259	65	35	for	for	ADP
bjp-15259	65	36	energy	energy	NOUN
bjp-15259	65	37	minimization	minimization	NOUN
bjp-15259	65	38	.	.	PUNCT
bjp-15259	66	1	to	to	PART
bjp-15259	66	2	minimize	minimize	VERB
bjp-15259	66	3	the	the	DET
bjp-15259	66	4	energy	energy	NOUN
bjp-15259	66	5	of	of	ADP
bjp-15259	66	6	the	the	DET
bjp-15259	66	7	3d	3d	NUM
bjp-15259	66	8	structure	structure	NOUN
bjp-15259	66	9	of	of	ADP
bjp-15259	66	10	angiogenin	angiogenin	PROPN
bjp-15259	66	11	,	,	PUNCT
bjp-15259	66	12	the	the	DET
bjp-15259	66	13	conjugate	conjugate	ADJ
bjp-15259	66	14	gradient	gradient	NOUN
bjp-15259	66	15	method	method	NOUN
bjp-15259	66	16	was	be	AUX
bjp-15259	66	17	employed	employ	VERB
bjp-15259	66	18	.	.	PUNCT
bjp-15259	67	1	also	also	ADV
bjp-15259	67	2	we	we	PRON
bjp-15259	67	3	employed	employ	VERB
bjp-15259	67	4	the	the	DET
bjp-15259	67	5	ifold	ifold	ADJ
bjp-15259	67	6	server	server	NOUN
bjp-15259	67	7	(	(	PUNCT
bjp-15259	67	8	sharma	sharma	PROPN
bjp-15259	67	9	et	et	PROPN
bjp-15259	67	10	al	al	PROPN
bjp-15259	67	11	.	.	PROPN
bjp-15259	67	12	,	,	PUNCT
bjp-15259	67	13	2006	2006	NUM
bjp-15259	67	14	)	)	PUNCT
bjp-15259	67	15	to	to	PART
bjp-15259	67	16	optimize	optimize	VERB
bjp-15259	67	17	the	the	DET
bjp-15259	67	18	angiogenin	angiogenin	NOUN
bjp-15259	67	19	3d	3d	NUM
bjp-15259	67	20	structure	structure	NOUN
bjp-15259	67	21	,	,	PUNCT
bjp-15259	67	22	for	for	ADP
bjp-15259	67	23	simulated	simulated	ADJ
bjp-15259	67	24	annealing	annealing	NOUN
bjp-15259	67	25	,	,	PUNCT
bjp-15259	67	26	which	which	PRON
bjp-15259	67	27	depend	depend	VERB
bjp-15259	67	28	on	on	ADP
bjp-15259	67	29	distinct	distinct	ADJ
bjp-15259	67	30	molecular	molecular	ADJ
bjp-15259	67	31	dynamics	dynamic	NOUN
bjp-15259	67	32	.	.	PUNCT
bjp-15259	68	1	this	this	DET
bjp-15259	68	2	server	server	NOUN
bjp-15259	68	3	efficiently	efficiently	ADV
bjp-15259	68	4	represents	represent	VERB
bjp-15259	68	5	the	the	DET
bjp-15259	68	6	immense	immense	ADJ
bjp-15259	68	7	conformational	conformational	ADJ
bjp-15259	68	8	space	space	NOUN
bjp-15259	68	9	of	of	ADP
bjp-15259	68	10	biomolecules	biomolecule	NOUN
bjp-15259	68	11	based	base	VERB
bjp-15259	68	12	on	on	ADP
bjp-15259	68	13	both	both	CCONJ
bjp-15259	68	14	the	the	DET
bjp-15259	68	15	length	length	NOUN
bjp-15259	68	16	and	and	CCONJ
bjp-15259	68	17	time	time	NOUN
bjp-15259	68	18	scales	scale	NOUN
bjp-15259	68	19	.	.	PUNCT
bjp-15259	69	1	substitutions	substitution	NOUN
bjp-15259	69	2	,	,	PUNCT
bjp-15259	69	3	deletions	deletion	NOUN
bjp-15259	69	4	and	and	CCONJ
bjp-15259	69	5	insertions	insertion	NOUN
bjp-15259	69	6	could	could	AUX
bjp-15259	69	7	be	be	AUX
bjp-15259	69	8	the	the	DET
bjp-15259	69	9	major	major	ADJ
bjp-15259	69	10	cause	cause	NOUN
bjp-15259	69	11	for	for	ADP
bjp-15259	69	12	the	the	DET
bjp-15259	69	13	divergence	divergence	NOUN
bjp-15259	69	14	of	of	ADP
bjp-15259	69	15	the	the	DET
bjp-15259	69	16	mutant	mutant	ADJ
bjp-15259	69	17	structure	structure	NOUN
bjp-15259	69	18	from	from	ADP
bjp-15259	69	19	the	the	DET
bjp-15259	69	20	native	native	ADJ
bjp-15259	69	21	structure	structure	NOUN
bjp-15259	69	22	(	(	PUNCT
bjp-15259	69	23	han	han	PROPN
bjp-15259	69	24	et	et	PROPN
bjp-15259	69	25	al	al	PROPN
bjp-15259	69	26	.	.	PROPN
bjp-15259	69	27	,	,	PUNCT
bjp-15259	69	28	2006	2006	NUM
bjp-15259	69	29	)	)	PUNCT
bjp-15259	69	30	and	and	CCONJ
bjp-15259	69	31	also	also	ADV
bjp-15259	69	32	these	these	DET
bjp-15259	69	33	two	two	NUM
bjp-15259	69	34	structures	structure	NOUN
bjp-15259	69	35	diverge	diverge	VERB
bjp-15259	69	36	to	to	PART
bjp-15259	69	37	modify	modify	VERB
bjp-15259	69	38	the	the	DET
bjp-15259	69	39	functional	functional	ADJ
bjp-15259	69	40	activity	activity	NOUN
bjp-15259	69	41	(	(	PUNCT
bjp-15259	69	42	varfolomeev	varfolomeev	PROPN
bjp-15259	69	43	et	et	PROPN
bjp-15259	69	44	al	al	PROPN
bjp-15259	69	45	.	.	PROPN
bjp-15259	69	46	,	,	PUNCT
bjp-15259	69	47	2002	2002	NUM
bjp-15259	69	48	)	)	PUNCT
bjp-15259	69	49	concerned	concern	VERB
bjp-15259	69	50	with	with	ADP
bjp-15259	69	51	the	the	DET
bjp-15259	69	52	inhibitors	inhibitor	NOUN
bjp-15259	69	53	’	'	PUNCT
bjp-15259	69	54	binding	bind	VERB
bjp-15259	69	55	efficiency	efficiency	NOUN
bjp-15259	69	56	as	as	SCONJ
bjp-15259	69	57	assessed	assess	VERB
bjp-15259	69	58	through	through	ADP
bjp-15259	69	59	rmsd	rmsd	NOUN
bjp-15259	69	60	calculation	calculation	NOUN
bjp-15259	69	61	.	.	PUNCT
bjp-15259	70	1	computation	computation	NOUN
bjp-15259	70	2	of	of	ADP
bjp-15259	70	3	intramolecular	intramolecular	ADJ
bjp-15259	70	4	interactions	interaction	NOUN
bjp-15259	70	5	by	by	ADP
bjp-15259	70	6	pic	pic	NOUN
bjp-15259	70	7	server	server	NOUN
bjp-15259	70	8	:	:	PUNCT
bjp-15259	70	9	in	in	ADP
bjp-15259	70	10	order	order	NOUN
bjp-15259	70	11	to	to	PART
bjp-15259	70	12	compute	compute	VERB
bjp-15259	70	13	the	the	DET
bjp-15259	70	14	intra	intra	ADJ
bjp-15259	70	15	-	-	ADJ
bjp-15259	70	16	molecular	molecular	ADJ
bjp-15259	70	17	interactions	interaction	NOUN
bjp-15259	70	18	for	for	ADP
bjp-15259	70	19	both	both	CCONJ
bjp-15259	70	20	the	the	DET
bjp-15259	70	21	native	native	ADJ
bjp-15259	70	22	and	and	CCONJ
bjp-15259	70	23	mutant	mutant	ADJ
bjp-15259	70	24	structures	structure	NOUN
bjp-15259	70	25	,	,	PUNCT
bjp-15259	70	26	pic	pic	NOUN
bjp-15259	70	27	server	server	NOUN
bjp-15259	70	28	was	be	AUX
bjp-15259	70	29	utilized	utilize	VERB
bjp-15259	70	30	.	.	PUNCT
bjp-15259	71	1	pic	pic	NOUN
bjp-15259	71	2	(	(	PUNCT
bjp-15259	71	3	protein	protein	NOUN
bjp-15259	71	4	interactions	interaction	NOUN
bjp-15259	71	5	calculator	calculator	NOUN
bjp-15259	71	6	)	)	PUNCT
bjp-15259	71	7	server	server	NOUN
bjp-15259	71	8	acquires	acquire	VERB
bjp-15259	71	9	the	the	DET
bjp-15259	71	10	caretesian	caretesian	ADJ
bjp-15259	71	11	coordinates	coordinate	NOUN
bjp-15259	71	12	of	of	ADP
bjp-15259	71	13	protein	protein	NOUN
bjp-15259	71	14	structure	structure	NOUN
bjp-15259	71	15	in	in	ADP
bjp-15259	71	16	the	the	DET
bjp-15259	71	17	pdb	pdb	NOUN
bjp-15259	71	18	format	format	NOUN
bjp-15259	71	19	.	.	PUNCT
bjp-15259	72	1	in	in	ADP
bjp-15259	72	2	perceiving	perceive	VERB
bjp-15259	72	3	the	the	DET
bjp-15259	72	4	molecular	molecular	ADJ
bjp-15259	72	5	basis	basis	NOUN
bjp-15259	72	6	of	of	ADP
bjp-15259	72	7	stability	stability	NOUN
bjp-15259	72	8	and	and	CCONJ
bjp-15259	72	9	proteins	protein	NOUN
bjp-15259	72	10	’	'	PUNCT
bjp-15259	72	11	function	function	NOUN
bjp-15259	72	12	and	and	CCONJ
bjp-15259	72	13	their	their	PRON
bjp-15259	72	14	complexes	complex	NOUN
bjp-15259	72	15	,	,	PUNCT
bjp-15259	72	16	the	the	DET
bjp-15259	72	17	inter	inter	ADJ
bjp-15259	72	18	protein	protein	NOUN
bjp-15259	72	19	structure	structure	NOUN
bjp-15259	72	20	interactions	interaction	NOUN
bjp-15259	72	21	and	and	CCONJ
bjp-15259	72	22	the	the	DET
bjp-15259	72	23	intra	intra	ADJ
bjp-15259	72	24	protein	protein	NOUN
bjp-15259	72	25	interactions	interaction	NOUN
bjp-15259	72	26	in	in	ADP
bjp-15259	72	27	an	an	DET
bjp-15259	72	28	congregation	congregation	NOUN
bjp-15259	72	29	were	be	AUX
bjp-15259	72	30	considered	consider	VERB
bjp-15259	72	31	important	important	ADJ
bjp-15259	72	32	.	.	PUNCT
bjp-15259	73	1	it	it	PRON
bjp-15259	73	2	emphasized	emphasize	VERB
bjp-15259	73	3	several	several	ADJ
bjp-15259	73	4	weak	weak	ADJ
bjp-15259	73	5	and	and	CCONJ
bjp-15259	73	6	strong	strong	ADJ
bjp-15259	73	7	interactions	interaction	NOUN
bjp-15259	73	8	which	which	PRON
bjp-15259	73	9	includes	include	VERB
bjp-15259	73	10	interaction	interaction	NOUN
bjp-15259	73	11	between	between	ADP
bjp-15259	73	12	apolar	apolar	ADJ
bjp-15259	73	13	residues	residue	NOUN
bjp-15259	73	14	,	,	PUNCT
bjp-15259	73	15	disulphide	disulphide	ADV
bjp-15259	73	16	bridges	bridge	NOUN
bjp-15259	73	17	,	,	PUNCT
bjp-15259	73	18	hydrogen	hydrogen	NOUN
bjp-15259	73	19	bonds	bond	NOUN
bjp-15259	73	20	influencing	influence	VERB
bjp-15259	73	21	secondary	secondary	ADJ
bjp-15259	73	22	and	and	CCONJ
bjp-15259	73	23	tertiary	tertiary	ADJ
bjp-15259	73	24	structure	structure	NOUN
bjp-15259	73	25	of	of	ADP
bjp-15259	73	26	protein	protein	NOUN
bjp-15259	73	27	,	,	PUNCT
bjp-15259	73	28	ionic	ionic	ADJ
bjp-15259	73	29	(	(	PUNCT
bjp-15259	73	30	electrostatic	electrostatic	ADJ
bjp-15259	73	31	)	)	PUNCT
bjp-15259	73	32	interactions	interaction	NOUN
bjp-15259	73	33	,	,	PUNCT
bjp-15259	73	34	aromatic	aromatic	ADJ
bjp-15259	73	35	-	-	PUNCT
bjp-15259	73	36	sulphur	sulphur	NOUN
bjp-15259	73	37	interactions	interaction	NOUN
bjp-15259	73	38	,	,	PUNCT
bjp-15259	73	39	cation	cation	NOUN
bjp-15259	73	40	-	-	PUNCT
bjp-15259	73	41	π	π	NOUN
bjp-15259	73	42	interactions	interaction	NOUN
bjp-15259	73	43	and	and	CCONJ
bjp-15259	73	44	aromatic	aromatic	ADJ
bjp-15259	73	45	-	-	PUNCT
bjp-15259	73	46	aromatic	aromatic	ADJ
bjp-15259	73	47	interactions	interaction	NOUN
bjp-15259	73	48	.	.	PUNCT
bjp-15259	74	1	the	the	DET
bjp-15259	74	2	pic	pic	NOUN
bjp-15259	74	3	server	server	NOUN
bjp-15259	74	4	(	(	PUNCT
bjp-15259	74	5	tina	tina	PROPN
bjp-15259	74	6	et	et	PROPN
bjp-15259	74	7	al	al	PROPN
bjp-15259	74	8	.	.	PROPN
bjp-15259	74	9	,	,	PUNCT
bjp-15259	74	10	2007	2007	NUM
bjp-15259	74	11	)	)	PUNCT
bjp-15259	74	12	has	have	AUX
bjp-15259	74	13	been	be	AUX
bjp-15259	74	14	available	available	ADJ
bjp-15259	74	15	at	at	ADP
bjp-15259	74	16	:	:	PUNCT
bjp-15259	74	17	http://crick.mbu.iisc.ernet.in/∼pic	http://crick.mbu.iisc.ernet.in/∼pic	NOUN
bjp-15259	74	18	.	.	NOUN
bjp-15259	74	19	analyzing	analyze	VERB
bjp-15259	74	20	the	the	DET
bjp-15259	74	21	binding	bind	VERB
bjp-15259	74	22	affinity	affinity	NOUN
bjp-15259	74	23	between	between	ADP
bjp-15259	74	24	angiogenin	angiogenin	NOUN
bjp-15259	74	25	and	and	CCONJ
bjp-15259	74	26	ribonuclease	ribonuclease	NOUN
bjp-15259	74	27	inhibitor	inhibitor	NOUN
bjp-15259	74	28	:	:	PUNCT
bjp-15259	74	29	for	for	ADP
bjp-15259	74	30	finding	find	VERB
bjp-15259	74	31	the	the	DET
bjp-15259	74	32	binding	bind	VERB
bjp-15259	74	33	affinity	affinity	NOUN
bjp-15259	74	34	between	between	ADP
bjp-15259	74	35	ang	ang	PROPN
bjp-15259	74	36	and	and	CCONJ
bjp-15259	74	37	ri	ri	PROPN
bjp-15259	74	38	(	(	PUNCT
bjp-15259	74	39	ribonuclease	ribonuclease	NOUN
bjp-15259	74	40	inhibitor	inhibitor	NOUN
bjp-15259	74	41	)	)	PUNCT
bjp-15259	74	42	complex	complex	NOUN
bjp-15259	74	43	,	,	PUNCT
bjp-15259	74	44	we	we	PRON
bjp-15259	74	45	used	use	VERB
bjp-15259	74	46	the	the	DET
bjp-15259	74	47	protein	protein	NOUN
bjp-15259	74	48	-	-	PUNCT
bjp-15259	74	49	protein	protein	NOUN
bjp-15259	74	50	docking	docking	NOUN
bjp-15259	74	51	server	server	NOUN
bjp-15259	74	52	,	,	PUNCT
bjp-15259	74	53	gramm	gramm	PROPN
bjp-15259	74	54	-	-	PUNCT
bjp-15259	74	55	x	x	PROPN
bjp-15259	74	56	(	(	PUNCT
bjp-15259	74	57	http://vakser.bioinformatics.ku.edu/resources/	http://vakser.bioinformatics.ku.edu/resources/	PROPN
bjp-15259	74	58	gramm	gramm	PROPN
bjp-15259	74	59	/	/	SYM
bjp-15259	74	60	grammx	grammx	PROPN
bjp-15259	74	61	)	)	PUNCT
bjp-15259	74	62	,	,	PUNCT
bjp-15259	74	63	gramm	gramm	PROPN
bjp-15259	74	64	fast	fast	ADJ
bjp-15259	74	65	fourier	fourier	NOUN
bjp-15259	74	66	transforma	transforma	NOUN
bjp-15259	74	67	tion	tion	PROPN
bjp-15259	74	68	methodology	methodology	NOUN
bjp-15259	74	69	based	base	VERB
bjp-15259	74	70	tool	tool	NOUN
bjp-15259	74	71	by	by	ADP
bjp-15259	74	72	employing	employ	VERB
bjp-15259	74	73	smoothed	smooth	VERB
bjp-15259	74	74	potentials	potential	NOUN
bjp-15259	74	75	,	,	PUNCT
bjp-15259	74	76	refinement	refinement	NOUN
bjp-15259	74	77	stage	stage	NOUN
bjp-15259	74	78	,	,	PUNCT
bjp-15259	74	79	and	and	CCONJ
bjp-15259	74	80	knowledge	knowledge	NOUN
bjp-15259	74	81	-	-	PUNCT
bjp-15259	74	82	based	base	VERB
bjp-15259	74	83	scoring	scoring	NOUN
bjp-15259	74	84	.	.	PUNCT
bjp-15259	75	1	it	it	PRON
bjp-15259	75	2	represented	represent	VERB
bjp-15259	75	3	a	a	DET
bjp-15259	75	4	new	new	ADJ
bjp-15259	75	5	implementation	implementation	NOUN
bjp-15259	75	6	that	that	PRON
bjp-15259	75	7	uses	use	VERB
bjp-15259	75	8	a	a	DET
bjp-15259	75	9	smoothed	smoothed	ADJ
bjp-15259	75	10	lennard	lennard	PROPN
bjp-15259	75	11	-	-	PUNCT
bjp-15259	75	12	jones	jones	PROPN
bjp-15259	75	13	potential	potential	NOUN
bjp-15259	75	14	on	on	ADP
bjp-15259	75	15	a	a	DET
bjp-15259	75	16	fine	fine	ADJ
bjp-15259	75	17	grid	grid	NOUN
bjp-15259	75	18	during	during	ADP
bjp-15259	75	19	the	the	DET
bjp-15259	75	20	global	global	ADJ
bjp-15259	75	21	search	search	NOUN
bjp-15259	75	22	fft	fft	NOUN
bjp-15259	75	23	stage	stage	NOUN
bjp-15259	75	24	,	,	PUNCT
bjp-15259	75	25	followed	follow	VERB
bjp-15259	75	26	by	by	ADP
bjp-15259	75	27	the	the	DET
bjp-15259	75	28	refinement	refinement	NOUN
bjp-15259	75	29	optimization	optimization	NOUN
bjp-15259	75	30	in	in	ADP
bjp-15259	75	31	continuous	continuous	ADJ
bjp-15259	75	32	coordinates	coordinate	NOUN
bjp-15259	75	33	and	and	CCONJ
bjp-15259	75	34	rescoring	rescore	VERB
bjp-15259	75	35	with	with	ADP
bjp-15259	75	36	several	several	ADJ
bjp-15259	75	37	knowledge	knowledge	NOUN
bjp-15259	75	38	-	-	PUNCT
bjp-15259	75	39	based	base	VERB
bjp-15259	75	40	potential	potential	ADJ
bjp-15259	75	41	terms	term	NOUN
bjp-15259	75	42	(	(	PUNCT
bjp-15259	75	43	tovchigrechiko	tovchigrechiko	NOUN
bjp-15259	75	44	et	et	NOUN
bjp-15259	75	45	al	al	PROPN
bjp-15259	75	46	.	.	PROPN
bjp-15259	75	47	,	,	PUNCT
bjp-15259	75	48	2006	2006	NUM
bjp-15259	75	49	)	)	PUNCT
bjp-15259	75	50	.	.	PUNCT
bjp-15259	76	1	then	then	ADV
bjp-15259	76	2	,	,	PUNCT
bjp-15259	76	3	the	the	DET
bjp-15259	76	4	docked	docked	ADJ
bjp-15259	76	5	protein	protein	NOUN
bjp-15259	76	6	complex	complex	NOUN
bjp-15259	76	7	was	be	AUX
bjp-15259	76	8	given	give	VERB
bjp-15259	76	9	to	to	ADP
bjp-15259	76	10	the	the	DET
bjp-15259	76	11	dfire	dfire	NOUN
bjp-15259	76	12	server	server	NOUN
bjp-15259	76	13	as	as	ADP
bjp-15259	76	14	an	an	DET
bjp-15259	76	15	input	input	NOUN
bjp-15259	76	16	for	for	ADP
bjp-15259	76	17	calculating	calculate	VERB
bjp-15259	76	18	the	the	DET
bjp-15259	76	19	binding	bind	VERB
bjp-15259	76	20	free	free	ADJ
bjp-15259	76	21	energy	energy	NOUN
bjp-15259	76	22	(	(	PUNCT
bjp-15259	76	23	δg	δg	NOUN
bjp-15259	76	24	)	)	PUNCT
bjp-15259	76	25	score	score	NOUN
bjp-15259	76	26	.	.	PUNCT
bjp-15259	77	1	it	it	PRON
bjp-15259	77	2	used	use	VERB
bjp-15259	77	3	a	a	DET
bjp-15259	77	4	new	new	ADJ
bjp-15259	77	5	reference	reference	NOUN
bjp-15259	77	6	state	state	NOUN
bjp-15259	77	7	called	call	VERB
bjp-15259	77	8	the	the	DET
bjp-15259	77	9	distance	distance	NOUN
bjp-15259	77	10	-	-	PUNCT
bjp-15259	77	11	scaled	scale	VERB
bjp-15259	77	12	,	,	PUNCT
bjp-15259	77	13	finite	finite	ADJ
bjp-15259	77	14	ideal	ideal	ADJ
bjp-15259	77	15	-	-	PUNCT
bjp-15259	77	16	gas	gas	NOUN
bjp-15259	77	17	reference	reference	NOUN
bjp-15259	77	18	(	(	PUNCT
bjp-15259	77	19	dfire	dfire	NOUN
bjp-15259	77	20	)	)	PUNCT
bjp-15259	77	21	state	state	NOUN
bjp-15259	77	22	.	.	PUNCT
bjp-15259	78	1	it	it	PRON
bjp-15259	78	2	was	be	AUX
bjp-15259	78	3	a	a	DET
bjp-15259	78	4	distancedependent	distancedependent	ADJ
bjp-15259	78	5	structure	structure	NOUN
bjp-15259	78	6	-	-	PUNCT
bjp-15259	78	7	derived	derive	VERB
bjp-15259	78	8	potential	potential	NOUN
bjp-15259	78	9	developed	develop	VERB
bjp-15259	78	10	so	so	ADV
bjp-15259	78	11	far	far	ADV
bjp-15259	78	12	and	and	CCONJ
bjp-15259	78	13	all	all	PRON
bjp-15259	78	14	employed	employ	VERB
bjp-15259	78	15	a	a	DET
bjp-15259	78	16	reference	reference	NOUN
bjp-15259	78	17	state	state	NOUN
bjp-15259	78	18	that	that	PRON
bjp-15259	78	19	could	could	AUX
bjp-15259	78	20	be	be	AUX
bjp-15259	78	21	characterized	characterize	VERB
bjp-15259	78	22	as	as	ADP
bjp-15259	78	23	a	a	DET
bjp-15259	78	24	residue	residue	NOUN
bjp-15259	78	25	(	(	PUNCT
bjp-15259	78	26	atom	atom	NOUN
bjp-15259	78	27	)	)	PUNCT
bjp-15259	78	28	-averaged	-averaged	ADJ
bjp-15259	78	29	state	state	NOUN
bjp-15259	78	30	.	.	PUNCT
bjp-15259	79	1	in	in	ADP
bjp-15259	79	2	addition	addition	NOUN
bjp-15259	79	3	,	,	PUNCT
bjp-15259	79	4	the	the	DET
bjp-15259	79	5	dfire	dfire	NOUN
bjp-15259	79	6	-	-	PUNCT
bjp-15259	79	7	based	base	VERB
bjp-15259	79	8	all	all	DET
bjp-15259	79	9	-	-	PUNCT
bjp-15259	79	10	atom	atom	NOUN
bjp-15259	79	11	potential	potential	NOUN
bjp-15259	79	12	provided	provide	VERB
bjp-15259	79	13	the	the	DET
bjp-15259	79	14	most	most	ADV
bjp-15259	79	15	accurate	accurate	ADJ
bjp-15259	79	16	prediction	prediction	NOUN
bjp-15259	79	17	of	of	ADP
bjp-15259	79	18	the	the	DET
bjp-15259	79	19	stabilities	stability	NOUN
bjp-15259	79	20	of	of	ADP
bjp-15259	79	21	mutants	mutant	NOUN
bjp-15259	79	22	based	base	VERB
bjp-15259	79	23	on	on	ADP
bjp-15259	79	24	knowledge	knowledge	NOUN
bjp-15259	79	25	-	-	PUNCT
bjp-15259	79	26	based	base	VERB
bjp-15259	79	27	all	all	DET
bjp-15259	79	28	-	-	PUNCT
bjp-15259	79	29	atom	atom	NOUN
bjp-15259	79	30	potentials	potential	NOUN
bjp-15259	79	31	.	.	PUNCT
bjp-15259	80	1	depicting	depict	VERB
bjp-15259	80	2	the	the	DET
bjp-15259	80	3	binding	bind	VERB
bjp-15259	80	4	pocket	pocket	NOUN
bjp-15259	80	5	flexibility	flexibility	NOUN
bjp-15259	80	6	using	use	VERB
bjp-15259	80	7	normal	normal	ADJ
bjp-15259	80	8	mode	mode	NOUN
bjp-15259	80	9	analysis	analysis	NOUN
bjp-15259	80	10	:	:	PUNCT
bjp-15259	80	11	the	the	DET
bjp-15259	80	12	atomic	atomic	ADJ
bjp-15259	80	13	motions	motion	NOUN
bjp-15259	80	14	in	in	ADP
bjp-15259	80	15	proteins	protein	NOUN
bjp-15259	80	16	measured	measure	VERB
bjp-15259	80	17	quantitatively	quantitatively	ADV
bjp-15259	80	18	could	could	AUX
bjp-15259	80	19	be	be	AUX
bjp-15259	80	20	acquired	acquire	VERB
bjp-15259	80	21	from	from	ADP
bjp-15259	80	22	the	the	DET
bjp-15259	80	23	mean	mean	ADJ
bjp-15259	80	24	square	square	ADJ
bjp-15259	80	25	fluctuations	fluctuation	NOUN
bjp-15259	80	26	of	of	ADP
bjp-15259	80	27	the	the	DET
bjp-15259	80	28	atoms	atom	NOUN
bjp-15259	80	29	corresponding	correspond	VERB
bjp-15259	80	30	to	to	ADP
bjp-15259	80	31	their	their	PRON
bjp-15259	80	32	regular	regular	ADJ
bjp-15259	80	33	positions	position	NOUN
bjp-15259	80	34	.	.	PUNCT
bjp-15259	81	1	this	this	PRON
bjp-15259	81	2	could	could	AUX
bjp-15259	81	3	be	be	AUX
bjp-15259	81	4	correlated	correlate	VERB
bjp-15259	81	5	to	to	ADP
bjp-15259	81	6	the	the	DET
bjp-15259	81	7	b	b	NOUN
bjp-15259	81	8	-	-	PUNCT
bjp-15259	81	9	factor	factor	NOUN
bjp-15259	81	10	(	(	PUNCT
bjp-15259	81	11	yuan	yuan	NOUN
bjp-15259	81	12	et	et	NOUN
bjp-15259	81	13	al	al	PROPN
bjp-15259	81	14	.	.	PROPN
bjp-15259	81	15	,	,	PUNCT
bjp-15259	81	16	2005	2005	NUM
bjp-15259	81	17	;	;	PUNCT
bjp-15259	81	18	ringe	ringe	VERB
bjp-15259	81	19	et	et	PROPN
bjp-15259	81	20	al	al	PROPN
bjp-15259	81	21	.	.	PROPN
bjp-15259	81	22	,	,	PUNCT
bjp-15259	81	23	1986	1986	NUM
bjp-15259	81	24	)	)	PUNCT
bjp-15259	81	25	.	.	PUNCT
bjp-15259	82	1	therefore	therefore	ADV
bjp-15259	82	2	,	,	PUNCT
bjp-15259	82	3	the	the	DET
bjp-15259	82	4	study	study	NOUN
bjp-15259	82	5	of	of	ADP
bjp-15259	82	6	bfactors	bfactor	NOUN
bjp-15259	82	7	provided	provide	VERB
bjp-15259	82	8	insights	insight	NOUN
bjp-15259	82	9	into	into	ADP
bjp-15259	82	10	protein	protein	NOUN
bjp-15259	82	11	motions	motion	NOUN
bjp-15259	82	12	,	,	PUNCT
bjp-15259	82	13	the	the	DET
bjp-15259	82	14	flexibility	flexibility	NOUN
bjp-15259	82	15	of	of	ADP
bjp-15259	82	16	amino	amino	ADJ
bjp-15259	82	17	acids	acid	NOUN
bjp-15259	82	18	and	and	CCONJ
bjp-15259	82	19	protein	protein	NOUN
bjp-15259	82	20	stability	stability	NOUN
bjp-15259	82	21	(	(	PUNCT
bjp-15259	82	22	parthasarathy	parthasarathy	PROPN
bjp-15259	82	23	et	et	PROPN
bjp-15259	82	24	al	al	PROPN
bjp-15259	82	25	.	.	PROPN
bjp-15259	82	26	,	,	PUNCT
bjp-15259	82	27	2000	2000	NUM
bjp-15259	82	28	)	)	PUNCT
bjp-15259	82	29	.	.	PUNCT
bjp-15259	83	1	in	in	ADP
bjp-15259	83	2	addition	addition	NOUN
bjp-15259	83	3	,	,	PUNCT
bjp-15259	83	4	the	the	DET
bjp-15259	83	5	protein	protein	NOUN
bjp-15259	83	6	function	function	NOUN
bjp-15259	83	7	and	and	CCONJ
bjp-15259	83	8	various	various	ADJ
bjp-15259	83	9	types	type	NOUN
bjp-15259	83	10	of	of	ADP
bjp-15259	83	11	interactions	interaction	NOUN
bjp-15259	83	12	depends	depend	VERB
bjp-15259	83	13	on	on	ADP
bjp-15259	83	14	protein	protein	NOUN
bjp-15259	83	15	flexibility	flexibility	NOUN
bjp-15259	83	16	of	of	ADP
bjp-15259	83	17	certain	certain	ADJ
bjp-15259	83	18	amino	amino	ADJ
bjp-15259	83	19	acids	acid	NOUN
bjp-15259	83	20	in	in	ADP
bjp-15259	83	21	a	a	DET
bjp-15259	83	22	protein	protein	NOUN
bjp-15259	83	23	(	(	PUNCT
bjp-15259	83	24	carlson	carlson	PROPN
bjp-15259	83	25	et	et	PROPN
bjp-15259	83	26	al	al	PROPN
bjp-15259	83	27	.	.	PROPN
bjp-15259	83	28	,	,	PUNCT
bjp-15259	83	29	2000	2000	NUM
bjp-15259	83	30	)	)	PUNCT
bjp-15259	83	31	.	.	PUNCT
bjp-15259	84	1	the	the	DET
bjp-15259	84	2	key	key	ADJ
bjp-15259	84	3	parameter	parameter	NOUN
bjp-15259	84	4	for	for	ADP
bjp-15259	84	5	understanding	understand	VERB
bjp-15259	84	6	the	the	DET
bjp-15259	84	7	binding	bind	VERB
bjp-15259	84	8	efficiency	efficiency	NOUN
bjp-15259	84	9	was	be	AUX
bjp-15259	84	10	the	the	DET
bjp-15259	84	11	flexibility	flexibility	NOUN
bjp-15259	84	12	of	of	ADP
bjp-15259	84	13	amino	amino	ADJ
bjp-15259	84	14	acids	acid	NOUN
bjp-15259	84	15	in	in	ADP
bjp-15259	84	16	the	the	DET
bjp-15259	84	17	binding	bind	VERB
bjp-15259	84	18	pocket	pocket	NOUN
bjp-15259	84	19	.	.	PUNCT
bjp-15259	85	1	indeed	indeed	ADV
bjp-15259	85	2	,	,	PUNCT
bjp-15259	85	3	the	the	DET
bjp-15259	85	4	binding	bind	VERB
bjp-15259	85	5	effect	effect	NOUN
bjp-15259	85	6	was	be	AUX
bjp-15259	85	7	impaired	impair	VERB
bjp-15259	85	8	by	by	ADP
bjp-15259	85	9	the	the	DET
bjp-15259	85	10	loss	loss	NOUN
bjp-15259	85	11	of	of	ADP
bjp-15259	85	12	flexibility	flexibility	NOUN
bjp-15259	85	13	(	(	PUNCT
bjp-15259	85	14	hinkle	hinkle	PROPN
bjp-15259	85	15	et	et	PROPN
bjp-15259	85	16	al	al	PROPN
bjp-15259	85	17	.	.	PROPN
bjp-15259	85	18	,	,	PUNCT
bjp-15259	85	19	2003	2003	NUM
bjp-15259	85	20	)	)	PUNCT
bjp-15259	85	21	and	and	CCONJ
bjp-15259	85	22	vice	vice	ADV
bjp-15259	85	23	versa	versa	ADV
bjp-15259	85	24	.	.	PUNCT
bjp-15259	86	1	so	so	ADV
bjp-15259	86	2	,	,	PUNCT
bjp-15259	86	3	the	the	DET
bjp-15259	86	4	bfactor	bfactor	NOUN
bjp-15259	86	5	helped	help	VERB
bjp-15259	86	6	in	in	ADP
bjp-15259	86	7	analyzing	analyze	VERB
bjp-15259	86	8	this	this	PRON
bjp-15259	86	9	,	,	PUNCT
bjp-15259	86	10	which	which	PRON
bjp-15259	86	11	is	be	AUX
bjp-15259	86	12	computed	compute	VERB
bjp-15259	86	13	from	from	ADP
bjp-15259	86	14	the	the	DET
bjp-15259	86	15	mean	mean	ADJ
bjp-15259	86	16	-	-	PUNCT
bjp-15259	86	17	square	square	ADJ
bjp-15259	86	18	displacement	displacement	NOUN
bjp-15259	86	19	<	<	X
bjp-15259	86	20	r2	r2	X
bjp-15259	86	21	>	>	X
bjp-15259	86	22	of	of	ADP
bjp-15259	86	23	the	the	DET
bjp-15259	86	24	lowest	low	ADJ
bjp-15259	86	25	frequency	frequency	NOUN
bjp-15259	86	26	normal	normal	ADJ
bjp-15259	86	27	mode	mode	NOUN
bjp-15259	86	28	using	use	VERB
bjp-15259	86	29	the	the	DET
bjp-15259	86	30	elnemo	elnemo	NOUN
bjp-15259	86	31	server	server	NOUN
bjp-15259	86	32	(	(	PUNCT
bjp-15259	86	33	suhre	suhre	PROPN
bjp-15259	86	34	et	et	PROPN
bjp-15259	86	35	al	al	PROPN
bjp-15259	86	36	.	.	PROPN
bjp-15259	86	37	,	,	PUNCT
bjp-15259	86	38	2004	2004	NUM
bjp-15259	86	39	)	)	PUNCT
bjp-15259	86	40	.	.	PUNCT
bjp-15259	87	1	results	result	NOUN
bjp-15259	87	2	and	and	CCONJ
bjp-15259	87	3	discussion	discussion	NOUN
bjp-15259	87	4	the	the	DET
bjp-15259	87	5	2ang	2ang	PROPN
bjp-15259	87	6	and	and	CCONJ
bjp-15259	87	7	a	a	DET
bjp-15259	87	8	total	total	NOUN
bjp-15259	87	9	of	of	ADP
bjp-15259	87	10	12	12	NUM
bjp-15259	87	11	variants	variant	NOUN
bjp-15259	87	12	namely	namely	ADV
bjp-15259	87	13	q36l	q36l	PROPN
bjp-15259	87	14	,	,	PUNCT
bjp-15259	87	15	k41e	k41e	NOUN
bjp-15259	87	16	,	,	PUNCT
bjp-15259	87	17	k41i	k41i	ADP
bjp-15259	87	18	,	,	PUNCT
bjp-15259	87	19	s52n	s52n	NOUN
bjp-15259	87	20	,	,	PUNCT
bjp-15259	87	21	r55k	r55k	PROPN
bjp-15259	87	22	,	,	PUNCT
bjp-15259	87	23	c63w	c63w	PROPN
bjp-15259	87	24	,	,	PUNCT
bjp-15259	87	25	k64i	k64i	NOUN
bjp-15259	87	26	,	,	PUNCT
bjp-15259	87	27	i70v	i70v	NOUN
bjp-15259	87	28	,	,	PUNCT
bjp-15259	87	29	k84e	k84e	PROPN
bjp-15259	87	30	,	,	PUNCT
bjp-15259	87	31	p136l	p136l	PROPN
bjp-15259	87	32	,	,	PUNCT
bjp-15259	87	33	v137i	v137i	PROPN
bjp-15259	87	34	and	and	CCONJ
bjp-15259	87	35	h138r	h138r	PROPN
bjp-15259	87	36	analyzed	analyze	VERB
bjp-15259	87	37	in	in	ADP
bjp-15259	87	38	our	our	PRON
bjp-15259	87	39	study	study	NOUN
bjp-15259	87	40	were	be	AUX
bjp-15259	87	41	extracted	extract	VERB
bjp-15259	87	42	from	from	ADP
bjp-15259	87	43	swissprot	swissprot	NOUN
bjp-15259	87	44	database	database	NOUN
bjp-15259	87	45	.	.	PUNCT
bjp-15259	88	1	among	among	ADP
bjp-15259	88	2	the	the	DET
bjp-15259	88	3	12	12	NUM
bjp-15259	88	4	variants	variant	NOUN
bjp-15259	88	5	,	,	PUNCT
bjp-15259	88	6	10	10	NUM
bjp-15259	88	7	variants	variant	NOUN
bjp-15259	88	8	were	be	AUX
bjp-15259	88	9	shown	show	VERB
bjp-15259	88	10	less	less	ADV
bjp-15259	88	11	stable	stable	ADJ
bjp-15259	88	12	using	use	VERB
bjp-15259	88	13	the	the	DET
bjp-15259	88	14	i	i	PROPN
bjp-15259	88	15	-	-	PUNCT
bjp-15259	88	16	mutant2.0	mutant2.0	PROPN
bjp-15259	88	17	server	server	NOUN
bjp-15259	88	18	(	(	PUNCT
bjp-15259	88	19	16	16	NUM
bjp-15259	88	20	)	)	PUNCT
bjp-15259	88	21	(	(	PUNCT
bjp-15259	88	22	table	table	NOUN
bjp-15259	88	23	i	i	PROPN
bjp-15259	88	24	)	)	PUNCT
bjp-15259	88	25	.	.	PUNCT
bjp-15259	89	1	among	among	ADP
bjp-15259	89	2	these	these	DET
bjp-15259	89	3	10	10	NUM
bjp-15259	89	4	variants	variant	NOUN
bjp-15259	89	5	,	,	PUNCT
bjp-15259	89	6	three	three	NUM
bjp-15259	89	7	variants	variant	NOUN
bjp-15259	89	8	showed	show	VERB
bjp-15259	89	9	a	a	DET
bjp-15259	89	10	δδg	δδg	NOUN
bjp-15259	89	11	value	value	NOUN
bjp-15259	89	12	<	<	X
bjp-15259	89	13	-2.0	-2.0	PROPN
bjp-15259	89	14	,	,	PUNCT
bjp-15259	89	15	two	two	NUM
bjp-15259	89	16	variants	variant	NOUN
bjp-15259	89	17	showed	show	VERB
bjp-15259	89	18	a	a	DET
bjp-15259	89	19	δδg	δδg	NOUN
bjp-15259	89	20	value	value	NOUN
bjp-15259	89	21	<	<	X
bjp-15259	89	22	-1.0	-1.0	PROPN
bjp-15259	89	23	and	and	CCONJ
bjp-15259	89	24	five	five	NUM
bjp-15259	89	25	variants	variant	NOUN
bjp-15259	89	26	showed	show	VERB
bjp-15259	89	27	a	a	DET
bjp-15259	89	28	δδg	δδg	NOUN
bjp-15259	89	29	value	value	NOUN
bjp-15259	89	30	>	>	X
bjp-15259	89	31	-1.0	-1.0	PROPN
bjp-15259	89	32	as	as	ADP
bjp-15259	89	33	in	in	ADP
bjp-15259	89	34	(	(	PUNCT
bjp-15259	89	35	table	table	NOUN
bjp-15259	89	36	i	i	NOUN
bjp-15259	89	37	)	)	PUNCT
bjp-15259	89	38	.	.	PUNCT
bjp-15259	90	1	among	among	ADP
bjp-15259	90	2	the	the	DET
bjp-15259	90	3	10	10	NUM
bjp-15259	90	4	variants	variant	NOUN
bjp-15259	90	5	that	that	PRON
bjp-15259	90	6	indicated	indicate	VERB
bjp-15259	90	7	a	a	DET
bjp-15259	90	8	negative	negative	ADJ
bjp-15259	90	9	δδg	δδg	NOUN
bjp-15259	90	10	,	,	PUNCT
bjp-15259	90	11	384	384	NUM
bjp-15259	90	12	bangladesh	bangladesh	PROPN
bjp-15259	90	13	j	j	PROPN
bjp-15259	90	14	pharmacol	pharmacol	PROPN
bjp-15259	90	15	2013	2013	NUM
bjp-15259	90	16	;	;	PUNCT
bjp-15259	90	17	8	8	NUM
bjp-15259	90	18	:	:	PUNCT
bjp-15259	90	19	382	382	NUM
bjp-15259	90	20	-	-	SYM
bjp-15259	90	21	389	389	NUM
bjp-15259	90	22	http://vakser.bioinformatics.ku.edu/resources/gramm/grammx	http://vakser.bioinformatics.ku.edu/resources/gramm/grammx	NOUN
bjp-15259	90	23	http://vakser.bioinformatics.ku.edu/resources/gramm/grammx	http://vakser.bioinformatics.ku.edu/resources/gramm/grammx	PROPN
bjp-15259	90	24	two	two	NUM
bjp-15259	90	25	variants	variant	NOUN
bjp-15259	90	26	(	(	PUNCT
bjp-15259	90	27	k41e	k41e	X
bjp-15259	90	28	and	and	CCONJ
bjp-15259	90	29	k84e	k84e	NOUN
bjp-15259	90	30	)	)	PUNCT
bjp-15259	90	31	altered	alter	VERB
bjp-15259	90	32	their	their	PRON
bjp-15259	90	33	positively	positively	ADV
bjp-15259	90	34	charged	charge	VERB
bjp-15259	90	35	amino	amino	NOUN
bjp-15259	90	36	acid	acid	NOUN
bjp-15259	90	37	into	into	ADP
bjp-15259	90	38	negatively	negatively	ADV
bjp-15259	90	39	charged	charge	VERB
bjp-15259	90	40	amino	amino	NOUN
bjp-15259	90	41	acid	acid	NOUN
bjp-15259	90	42	,	,	PUNCT
bjp-15259	90	43	one	one	NUM
bjp-15259	90	44	variant	variant	NOUN
bjp-15259	90	45	(	(	PUNCT
bjp-15259	90	46	s52n	s52n	NOUN
bjp-15259	90	47	)	)	PUNCT
bjp-15259	90	48	retained	retain	VERB
bjp-15259	90	49	its	its	PRON
bjp-15259	90	50	polar	polar	ADJ
bjp-15259	90	51	uncharged	uncharged	ADJ
bjp-15259	90	52	property	property	NOUN
bjp-15259	90	53	.	.	PUNCT
bjp-15259	91	1	one	one	NUM
bjp-15259	91	2	variant	variant	NOUN
bjp-15259	91	3	,	,	PUNCT
bjp-15259	91	4	(	(	PUNCT
bjp-15259	91	5	r55k	r55k	NOUN
bjp-15259	91	6	)	)	PUNCT
bjp-15259	91	7	retained	retain	VERB
bjp-15259	91	8	its	its	PRON
bjp-15259	91	9	positively	positively	ADV
bjp-15259	91	10	charged	charge	VERB
bjp-15259	91	11	property	property	NOUN
bjp-15259	91	12	and	and	CCONJ
bjp-15259	91	13	two	two	NUM
bjp-15259	91	14	variants	variant	NOUN
bjp-15259	91	15	(	(	PUNCT
bjp-15259	91	16	i70v	i70v	PROPN
bjp-15259	91	17	and	and	CCONJ
bjp-15259	91	18	v137i	v137i	PROPN
bjp-15259	91	19	)	)	PUNCT
bjp-15259	91	20	retained	retain	VERB
bjp-15259	91	21	its	its	PRON
bjp-15259	91	22	non	non	ADJ
bjp-15259	91	23	polar	polar	ADJ
bjp-15259	91	24	properties	property	NOUN
bjp-15259	91	25	followed	follow	VERB
bjp-15259	91	26	by	by	ADP
bjp-15259	91	27	variants	variant	NOUN
bjp-15259	91	28	viz	viz	PROPN
bjp-15259	91	29	.	.	PROPN
bjp-15259	91	30	,	,	PUNCT
bjp-15259	91	31	q36l	q36l	PROPN
bjp-15259	91	32	,	,	PUNCT
bjp-15259	91	33	k41i	k41i	ADP
bjp-15259	91	34	,	,	PUNCT
bjp-15259	91	35	c63w	c63w	PROPN
bjp-15259	91	36	and	and	CCONJ
bjp-15259	91	37	h138r	h138r	PROPN
bjp-15259	91	38	which	which	PRON
bjp-15259	91	39	changed	change	VERB
bjp-15259	91	40	amino	amino	ADJ
bjp-15259	91	41	acids	acid	NOUN
bjp-15259	91	42	from	from	ADP
bjp-15259	91	43	polar	polar	ADJ
bjp-15259	91	44	uncharged	uncharged	ADJ
bjp-15259	91	45	to	to	ADP
bjp-15259	91	46	non	non	PRON
bjp-15259	91	47	polar	polar	ADJ
bjp-15259	91	48	,	,	PUNCT
bjp-15259	91	49	positively	positively	ADV
bjp-15259	91	50	charged	charge	VERB
bjp-15259	91	51	to	to	ADP
bjp-15259	91	52	non	non	VERB
bjp-15259	91	53	polar	polar	ADJ
bjp-15259	91	54	,	,	PUNCT
bjp-15259	91	55	polar	polar	ADJ
bjp-15259	91	56	uncharged	uncharged	ADJ
bjp-15259	91	57	into	into	ADP
bjp-15259	91	58	aromatic	aromatic	ADJ
bjp-15259	91	59	and	and	CCONJ
bjp-15259	91	60	positive	positive	ADJ
bjp-15259	91	61	into	into	ADP
bjp-15259	91	62	aromatic	aromatic	NOUN
bjp-15259	91	63	.	.	PUNCT
bjp-15259	92	1	infact	infact	PROPN
bjp-15259	92	2	,	,	PUNCT
bjp-15259	92	3	only	only	ADV
bjp-15259	92	4	in	in	ADP
bjp-15259	92	5	the	the	DET
bjp-15259	92	6	view	view	NOUN
bjp-15259	92	7	of	of	ADP
bjp-15259	92	8	amino	amino	NOUN
bjp-15259	92	9	acid	acid	NOUN
bjp-15259	92	10	substitution	substitution	NOUN
bjp-15259	92	11	concerned	concern	VERB
bjp-15259	92	12	with	with	ADP
bjp-15259	92	13	physico	physico	NOUN
bjp-15259	92	14	-chemical	-chemical	ADJ
bjp-15259	92	15	properties	property	NOUN
bjp-15259	92	16	,	,	PUNCT
bjp-15259	92	17	the	the	DET
bjp-15259	92	18	detrimental	detrimental	ADJ
bjp-15259	92	19	effect	effect	NOUN
bjp-15259	92	20	might	might	AUX
bjp-15259	92	21	not	not	PART
bjp-15259	92	22	perhaps	perhaps	ADV
bjp-15259	92	23	be	be	AUX
bjp-15259	92	24	identified	identify	VERB
bjp-15259	92	25	.	.	PUNCT
bjp-15259	93	1	instead	instead	ADV
bjp-15259	93	2	,	,	PUNCT
bjp-15259	93	3	taking	take	VERB
bjp-15259	93	4	account	account	NOUN
bjp-15259	93	5	of	of	ADP
bjp-15259	93	6	the	the	DET
bjp-15259	93	7	sequence	sequence	NOUN
bjp-15259	93	8	conservation	conservation	NOUN
bjp-15259	93	9	in	in	ADP
bjp-15259	93	10	addition	addition	NOUN
bjp-15259	93	11	to	to	ADP
bjp-15259	93	12	the	the	DET
bjp-15259	93	13	above	above	ADJ
bjp-15259	93	14	believed	believe	VERB
bjp-15259	93	15	properties	property	NOUN
bjp-15259	93	16	could	could	AUX
bjp-15259	93	17	be	be	AUX
bjp-15259	93	18	advantageous	advantageous	ADJ
bjp-15259	93	19	and	and	CCONJ
bjp-15259	93	20	dependable	dependable	ADJ
bjp-15259	93	21	to	to	PART
bjp-15259	93	22	hit	hit	VERB
bjp-15259	93	23	upon	upon	SCONJ
bjp-15259	93	24	the	the	DET
bjp-15259	93	25	deleterious	deleterious	ADJ
bjp-15259	93	26	effect	effect	NOUN
bjp-15259	93	27	of	of	ADP
bjp-15259	93	28	missense	missense	NOUN
bjp-15259	93	29	mutations	mutation	NOUN
bjp-15259	93	30	(	(	PUNCT
bjp-15259	93	31	hinkle	hinkle	PROPN
bjp-15259	93	32	et	et	PROPN
bjp-15259	93	33	al	al	PROPN
bjp-15259	93	34	.	.	PROPN
bjp-15259	93	35	,	,	PUNCT
bjp-15259	93	36	2003	2003	NUM
bjp-15259	93	37	)	)	PUNCT
bjp-15259	93	38	the	the	DET
bjp-15259	93	39	degree	degree	NOUN
bjp-15259	93	40	of	of	ADP
bjp-15259	93	41	conservation	conservation	NOUN
bjp-15259	93	42	of	of	ADP
bjp-15259	93	43	a	a	DET
bjp-15259	93	44	particular	particular	ADJ
bjp-15259	93	45	position	position	NOUN
bjp-15259	93	46	in	in	ADP
bjp-15259	93	47	a	a	DET
bjp-15259	93	48	protein	protein	NOUN
bjp-15259	93	49	was	be	AUX
bjp-15259	93	50	determined	determine	VERB
bjp-15259	93	51	using	use	VERB
bjp-15259	93	52	sequence	sequence	NOUN
bjp-15259	93	53	homology	homology	NOUN
bjp-15259	93	54	based	base	VERB
bjp-15259	93	55	tool	tool	NOUN
bjp-15259	93	56	sift	sift	NOUN
bjp-15259	93	57	(	(	PUNCT
bjp-15259	93	58	ng	ng	PROPN
bjp-15259	93	59	et	et	PROPN
bjp-15259	93	60	al	al	PROPN
bjp-15259	93	61	.	.	PROPN
bjp-15259	93	62	,	,	PUNCT
bjp-15259	93	63	2003	2003	NUM
bjp-15259	93	64	)	)	PUNCT
bjp-15259	93	65	.	.	PUNCT
bjp-15259	94	1	the	the	DET
bjp-15259	94	2	protein	protein	NOUN
bjp-15259	94	3	sequences	sequence	NOUN
bjp-15259	94	4	of	of	ADP
bjp-15259	94	5	the	the	DET
bjp-15259	94	6	30	30	NUM
bjp-15259	94	7	variants	variant	NOUN
bjp-15259	94	8	were	be	AUX
bjp-15259	94	9	submitted	submit	VERB
bjp-15259	94	10	to	to	PART
bjp-15259	94	11	sift	sift	VERB
bjp-15259	94	12	to	to	PART
bjp-15259	94	13	determine	determine	VERB
bjp-15259	94	14	their	their	PRON
bjp-15259	94	15	tolerance	tolerance	NOUN
bjp-15259	94	16	indices	index	NOUN
bjp-15259	94	17	.	.	PUNCT
bjp-15259	95	1	as	as	ADP
bjp-15259	95	2	the	the	DET
bjp-15259	95	3	tolerance	tolerance	NOUN
bjp-15259	95	4	level	level	NOUN
bjp-15259	95	5	increases	increase	NOUN
bjp-15259	95	6	,	,	PUNCT
bjp-15259	95	7	the	the	DET
bjp-15259	95	8	functional	functional	ADJ
bjp-15259	95	9	influence	influence	NOUN
bjp-15259	95	10	of	of	ADP
bjp-15259	95	11	the	the	DET
bjp-15259	95	12	amino	amino	NOUN
bjp-15259	95	13	acid	acid	NOUN
bjp-15259	95	14	substitution	substitution	NOUN
bjp-15259	95	15	decreases	decrease	NOUN
bjp-15259	95	16	and	and	CCONJ
bjp-15259	95	17	vice	vice	NOUN
bjp-15259	95	18	versa	versa	ADV
bjp-15259	95	19	.	.	PUNCT
bjp-15259	96	1	of	of	ADP
bjp-15259	96	2	the	the	DET
bjp-15259	96	3	12	12	NUM
bjp-15259	96	4	variants	variant	NOUN
bjp-15259	96	5	,	,	PUNCT
bjp-15259	96	6	6	6	NUM
bjp-15259	96	7	variants	variant	NOUN
bjp-15259	96	8	seem	seem	VERB
bjp-15259	96	9	deleterious	deleterious	ADJ
bjp-15259	96	10	,	,	PUNCT
bjp-15259	96	11	having	have	VERB
bjp-15259	96	12	tolerance	tolerance	NOUN
bjp-15259	96	13	index	index	NOUN
bjp-15259	96	14	scores	score	NOUN
bjp-15259	96	15	of	of	ADP
bjp-15259	96	16	≤0.05	≤0.05	NOUN
bjp-15259	96	17	(	(	PUNCT
bjp-15259	96	18	table	table	NOUN
bjp-15259	96	19	i	i	NOUN
bjp-15259	96	20	)	)	PUNCT
bjp-15259	96	21	.	.	PUNCT
bjp-15259	97	1	among	among	ADP
bjp-15259	97	2	these	these	DET
bjp-15259	97	3	6	6	NUM
bjp-15259	97	4	variants	variant	NOUN
bjp-15259	97	5	,	,	PUNCT
bjp-15259	97	6	5	5	NUM
bjp-15259	97	7	variants	variant	NOUN
bjp-15259	97	8	showed	show	VERB
bjp-15259	97	9	a	a	DET
bjp-15259	97	10	very	very	ADV
bjp-15259	97	11	high	high	ADJ
bjp-15259	97	12	deleterious	deleterious	ADJ
bjp-15259	97	13	tolerance	tolerance	NOUN
bjp-15259	97	14	index	index	NOUN
bjp-15259	97	15	score	score	NOUN
bjp-15259	97	16	of	of	ADP
bjp-15259	97	17	0.00	0.00	NUM
bjp-15259	97	18	and	and	CCONJ
bjp-15259	97	19	one	one	NUM
bjp-15259	97	20	had	have	VERB
bjp-15259	97	21	a	a	DET
bjp-15259	97	22	tolerance	tolerance	NOUN
bjp-15259	97	23	index	index	NOUN
bjp-15259	97	24	score	score	NOUN
bjp-15259	97	25	of	of	ADP
bjp-15259	97	26	0.05	0.05	NUM
bjp-15259	97	27	(	(	PUNCT
bjp-15259	97	28	table	table	NOUN
bjp-15259	97	29	i	i	NOUN
bjp-15259	97	30	)	)	PUNCT
bjp-15259	97	31	.	.	PUNCT
bjp-15259	98	1	interestingly	interestingly	ADV
bjp-15259	98	2	,	,	PUNCT
bjp-15259	98	3	4	4	NUM
bjp-15259	98	4	deleterious	deleterious	ADJ
bjp-15259	98	5	variants	variant	NOUN
bjp-15259	98	6	identified	identify	VERB
bjp-15259	98	7	by	by	ADP
bjp-15259	98	8	sift	sift	NOUN
bjp-15259	98	9	were	be	AUX
bjp-15259	98	10	also	also	ADV
bjp-15259	98	11	found	find	VERB
bjp-15259	98	12	less	less	ADV
bjp-15259	98	13	stable	stable	ADJ
bjp-15259	98	14	by	by	ADP
bjp-15259	98	15	the	the	DET
bjp-15259	98	16	i	i	PROPN
bjp-15259	98	17	-	-	PUNCT
bjp-15259	98	18	mutant2.0	mutant2.0	PROPN
bjp-15259	98	19	server	server	NOUN
bjp-15259	98	20	.	.	PUNCT
bjp-15259	99	1	structural	structural	ADJ
bjp-15259	99	2	level	level	NOUN
bjp-15259	99	3	alterations	alteration	NOUN
bjp-15259	99	4	were	be	AUX
bjp-15259	99	5	worked	work	VERB
bjp-15259	99	6	out	out	ADP
bjp-15259	99	7	by	by	ADP
bjp-15259	99	8	polyphen	polyphen	ADJ
bjp-15259	99	9	program	program	NOUN
bjp-15259	99	10	.	.	PUNCT
bjp-15259	100	1	protein	protein	NOUN
bjp-15259	100	2	sequence	sequence	NOUN
bjp-15259	100	3	with	with	ADP
bjp-15259	100	4	the	the	DET
bjp-15259	100	5	position	position	NOUN
bjp-15259	100	6	of	of	ADP
bjp-15259	100	7	mutation	mutation	NOUN
bjp-15259	100	8	and	and	CCONJ
bjp-15259	100	9	the	the	DET
bjp-15259	100	10	variants	variant	NOUN
bjp-15259	100	11	of	of	ADP
bjp-15259	100	12	amino	amino	NOUN
bjp-15259	100	13	acid	acid	NOUN
bjp-15259	100	14	linked	link	VERB
bjp-15259	100	15	with	with	ADP
bjp-15259	100	16	the	the	DET
bjp-15259	100	17	12	12	NUM
bjp-15259	100	18	single	single	ADJ
bjp-15259	100	19	point	point	NOUN
bjp-15259	100	20	mutants	mutant	NOUN
bjp-15259	100	21	were	be	AUX
bjp-15259	100	22	submitted	submit	VERB
bjp-15259	100	23	to	to	ADP
bjp-15259	100	24	the	the	DET
bjp-15259	100	25	polyphen	polyphen	ADJ
bjp-15259	100	26	server	server	NOUN
bjp-15259	100	27	(	(	PUNCT
bjp-15259	100	28	ramensky	ramensky	PROPN
bjp-15259	100	29	et	et	PROPN
bjp-15259	100	30	al	al	PROPN
bjp-15259	100	31	.	.	PROPN
bjp-15259	100	32	,	,	PUNCT
bjp-15259	100	33	2002	2002	NUM
bjp-15259	100	34	)	)	PUNCT
bjp-15259	100	35	.	.	PUNCT
bjp-15259	101	1	a	a	DET
bjp-15259	101	2	psic	psic	ADJ
bjp-15259	101	3	score	score	NOUN
bjp-15259	101	4	difference	difference	NOUN
bjp-15259	101	5	of	of	ADP
bjp-15259	101	6	1.1	1.1	NUM
bjp-15259	101	7	and	and	CCONJ
bjp-15259	101	8	greater	great	ADJ
bjp-15259	101	9	was	be	AUX
bjp-15259	101	10	regarded	regard	VERB
bjp-15259	101	11	to	to	PART
bjp-15259	101	12	be	be	AUX
bjp-15259	101	13	damaging	damaging	ADJ
bjp-15259	101	14	.	.	PUNCT
bjp-15259	102	1	it	it	PRON
bjp-15259	102	2	could	could	AUX
bjp-15259	102	3	be	be	AUX
bjp-15259	102	4	known	know	VERB
bjp-15259	102	5	from	from	ADP
bjp-15259	102	6	table	table	NOUN
bjp-15259	102	7	i	i	PRON
bjp-15259	102	8	that	that	SCONJ
bjp-15259	102	9	,	,	PUNCT
bjp-15259	102	10	among	among	ADP
bjp-15259	102	11	the	the	DET
bjp-15259	102	12	12	12	NUM
bjp-15259	102	13	variants	variant	NOUN
bjp-15259	102	14	,	,	PUNCT
bjp-15259	102	15	6	6	NUM
bjp-15259	102	16	were	be	AUX
bjp-15259	102	17	found	find	VERB
bjp-15259	102	18	damaging	damaging	ADJ
bjp-15259	102	19	by	by	ADP
bjp-15259	102	20	polyphen	polyphen	ADV
bjp-15259	102	21	.	.	PUNCT
bjp-15259	103	1	also	also	ADV
bjp-15259	103	2	these	these	DET
bjp-15259	103	3	variants	variant	NOUN
bjp-15259	103	4	showed	show	VERB
bjp-15259	103	5	a	a	DET
bjp-15259	103	6	difference	difference	NOUN
bjp-15259	103	7	in	in	ADP
bjp-15259	103	8	psic	psic	ADJ
bjp-15259	103	9	score	score	NOUN
bjp-15259	103	10	from	from	ADP
bjp-15259	103	11	0.13	0.13	NUM
bjp-15259	103	12	to	to	ADP
bjp-15259	103	13	4.091	4.091	NUM
bjp-15259	103	14	.	.	PUNCT
bjp-15259	104	1	it	it	PRON
bjp-15259	104	2	was	be	AUX
bjp-15259	104	3	to	to	PART
bjp-15259	104	4	be	be	AUX
bjp-15259	104	5	distinguished	distinguish	VERB
bjp-15259	104	6	that	that	SCONJ
bjp-15259	104	7	the	the	DET
bjp-15259	104	8	variants	variant	NOUN
bjp-15259	104	9	that	that	PRON
bjp-15259	104	10	were	be	AUX
bjp-15259	104	11	all	all	PRON
bjp-15259	104	12	found	find	VERB
bjp-15259	104	13	damaging	damaging	ADJ
bjp-15259	104	14	by	by	ADP
bjp-15259	104	15	polyphen	polyphen	ADV
bjp-15259	104	16	except	except	SCONJ
bjp-15259	104	17	for	for	ADP
bjp-15259	104	18	k41i	k41i	NOUN
bjp-15259	104	19	were	be	AUX
bjp-15259	104	20	also	also	ADV
bjp-15259	104	21	identified	identify	VERB
bjp-15259	104	22	as	as	ADP
bjp-15259	104	23	deleterious	deleterious	ADJ
bjp-15259	104	24	based	base	VERB
bjp-15259	104	25	on	on	ADP
bjp-15259	104	26	the	the	DET
bjp-15259	104	27	sift	sift	PROPN
bjp-15259	104	28	server	server	NOUN
bjp-15259	104	29	.	.	PUNCT
bjp-15259	105	1	the	the	DET
bjp-15259	105	2	3	3	NUM
bjp-15259	105	3	most	most	ADV
bjp-15259	105	4	potential	potential	ADJ
bjp-15259	105	5	detrimental	detrimental	ADJ
bjp-15259	105	6	point	point	NOUN
bjp-15259	105	7	mutation	mutation	NOUN
bjp-15259	105	8	were	be	AUX
bjp-15259	105	9	considered	consider	VERB
bjp-15259	105	10	(	(	PUNCT
bjp-15259	105	11	q36l	q36l	PROPN
bjp-15259	105	12	,	,	PUNCT
bjp-15259	105	13	c63w	c63w	PROPN
bjp-15259	105	14	and	and	CCONJ
bjp-15259	105	15	h138r	h138r	PROPN
bjp-15259	105	16	)	)	PUNCT
bjp-15259	105	17	for	for	ADP
bjp-15259	105	18	further	further	ADJ
bjp-15259	105	19	course	course	NOUN
bjp-15259	105	20	of	of	ADP
bjp-15259	105	21	investigations	investigation	NOUN
bjp-15259	105	22	because	because	SCONJ
bjp-15259	105	23	they	they	PRON
bjp-15259	105	24	were	be	AUX
bjp-15259	105	25	usually	usually	ADV
bjp-15259	105	26	less	less	ADV
bjp-15259	105	27	stable	stable	ADJ
bjp-15259	105	28	,	,	PUNCT
bjp-15259	105	29	deleterious	deleterious	ADJ
bjp-15259	105	30	,	,	PUNCT
bjp-15259	105	31	and	and	CCONJ
bjp-15259	105	32	damaging	damage	VERB
bjp-15259	105	33	by	by	ADP
bjp-15259	105	34	the	the	DET
bjp-15259	105	35	i	i	PROPN
bjp-15259	105	36	-	-	PUNCT
bjp-15259	105	37	mutant2.0	mutant2.0	PROPN
bjp-15259	105	38	,	,	PUNCT
bjp-15259	105	39	sift	sift	ADJ
bjp-15259	105	40	and	and	CCONJ
bjp-15259	105	41	polyphen	polyphen	ADV
bjp-15259	105	42	servers	server	NOUN
bjp-15259	105	43	respectively	respectively	ADV
bjp-15259	105	44	(	(	PUNCT
bjp-15259	105	45	capriotti	capriotti	NOUN
bjp-15259	105	46	et	et	PROPN
bjp-15259	105	47	al	al	PROPN
bjp-15259	105	48	.	.	PROPN
bjp-15259	105	49	,	,	PUNCT
bjp-15259	105	50	2005	2005	NUM
bjp-15259	105	51	;	;	PUNCT
bjp-15259	105	52	ng	ng	PROPN
bjp-15259	105	53	et	et	PROPN
bjp-15259	105	54	al	al	PROPN
bjp-15259	105	55	.	.	PROPN
bjp-15259	105	56	,	,	PUNCT
bjp-15259	105	57	2003	2003	NUM
bjp-15259	105	58	;	;	PUNCT
bjp-15259	105	59	ramensky	ramensky	PROPN
bjp-15259	105	60	et	et	PROPN
bjp-15259	105	61	al	al	PROPN
bjp-15259	105	62	.	.	PROPN
bjp-15259	105	63	,	,	PUNCT
bjp-15259	105	64	2002	2002	NUM
bjp-15259	105	65	)	)	PUNCT
bjp-15259	105	66	.	.	PUNCT
bjp-15259	106	1	we	we	PRON
bjp-15259	106	2	considered	consider	VERB
bjp-15259	106	3	the	the	DET
bjp-15259	106	4	statistical	statistical	ADJ
bjp-15259	106	5	accuracy	accuracy	NOUN
bjp-15259	106	6	of	of	ADP
bjp-15259	106	7	these	these	DET
bjp-15259	106	8	three	three	NUM
bjp-15259	106	9	programs	program	NOUN
bjp-15259	106	10	,	,	PUNCT
bjp-15259	106	11	i	i	PRON
bjp-15259	106	12	-	-	PUNCT
bjp-15259	106	13	mutant	mutant	NOUN
bjp-15259	106	14	improved	improve	VERB
bjp-15259	106	15	the	the	DET
bjp-15259	106	16	quality	quality	NOUN
bjp-15259	106	17	of	of	ADP
bjp-15259	106	18	the	the	DET
bjp-15259	106	19	prediction	prediction	NOUN
bjp-15259	106	20	of	of	ADP
bjp-15259	106	21	the	the	DET
bjp-15259	106	22	free	free	ADJ
bjp-15259	106	23	energy	energy	NOUN
bjp-15259	106	24	change	change	NOUN
bjp-15259	106	25	caused	cause	VERB
bjp-15259	106	26	by	by	ADP
bjp-15259	106	27	single	single	ADJ
bjp-15259	106	28	point	point	NOUN
bjp-15259	106	29	protein	protein	NOUN
bjp-15259	106	30	mutations	mutation	NOUN
bjp-15259	106	31	by	by	ADP
bjp-15259	106	32	adopting	adopt	VERB
bjp-15259	106	33	a	a	DET
bjp-15259	106	34	hypothesis	hypothesis	NOUN
bjp-15259	106	35	of	of	ADP
bjp-15259	106	36	thermodynamic	thermodynamic	ADJ
bjp-15259	106	37	reversibility	reversibility	NOUN
bjp-15259	106	38	of	of	ADP
bjp-15259	106	39	the	the	DET
bjp-15259	106	40	existing	exist	VERB
bjp-15259	106	41	experimental	experimental	ADJ
bjp-15259	106	42	data	datum	NOUN
bjp-15259	106	43	.	.	PUNCT
bjp-15259	107	1	the	the	DET
bjp-15259	107	2	accuracy	accuracy	NOUN
bjp-15259	107	3	in	in	ADP
bjp-15259	107	4	prediction	prediction	NOUN
bjp-15259	107	5	of	of	ADP
bjp-15259	107	6	sequence	sequence	NOUN
bjp-15259	107	7	and	and	CCONJ
bjp-15259	107	8	structure	structure	NOUN
bjp-15259	107	9	based	base	VERB
bjp-15259	107	10	values	value	NOUN
bjp-15259	107	11	were	be	AUX
bjp-15259	107	12	78	78	NUM
bjp-15259	107	13	and	and	CCONJ
bjp-15259	107	14	84	84	NUM
bjp-15259	107	15	%	%	NOUN
bjp-15259	107	16	with	with	ADP
bjp-15259	107	17	a	a	DET
bjp-15259	107	18	correlation	correlation	NOUN
bjp-15259	107	19	coefficient	coefficient	NOUN
bjp-15259	107	20	of	of	ADP
bjp-15259	107	21	0.56	0.56	NUM
bjp-15259	107	22	and	and	CCONJ
bjp-15259	107	23	0.69	0.69	NUM
bjp-15259	107	24	,	,	PUNCT
bjp-15259	107	25	respectively	respectively	ADV
bjp-15259	107	26	(	(	PUNCT
bjp-15259	107	27	36	36	NUM
bjp-15259	107	28	)	)	PUNCT
bjp-15259	107	29	.	.	PUNCT
bjp-15259	108	1	sift	sift	PROPN
bjp-15259	108	2	correctly	correctly	ADV
bjp-15259	108	3	predicted	predict	VERB
bjp-15259	108	4	69	69	NUM
bjp-15259	108	5	%	%	NOUN
bjp-15259	108	6	of	of	ADP
bjp-15259	108	7	the	the	DET
bjp-15259	108	8	substitutions	substitution	NOUN
bjp-15259	108	9	associated	associate	VERB
bjp-15259	108	10	with	with	ADP
bjp-15259	108	11	the	the	DET
bjp-15259	108	12	disease	disease	NOUN
bjp-15259	108	13	that	that	PRON
bjp-15259	108	14	affect	affect	VERB
bjp-15259	108	15	protein	protein	NOUN
bjp-15259	108	16	function	function	NOUN
bjp-15259	108	17	.	.	PUNCT
bjp-15259	109	1	polyphen-2	polyphen-2	X
bjp-15259	109	2	evaluated	evaluate	VERB
bjp-15259	109	3	rare	rare	ADJ
bjp-15259	109	4	alleles	allele	NOUN
bjp-15259	109	5	at	at	ADP
bjp-15259	109	6	loci	loci	NOUN
bjp-15259	109	7	potentially	potentially	ADV
bjp-15259	109	8	involved	involve	VERB
bjp-15259	109	9	in	in	ADP
bjp-15259	109	10	complex	complex	ADJ
bjp-15259	109	11	phenotypes	phenotype	NOUN
bjp-15259	109	12	,	,	PUNCT
bjp-15259	109	13	densely	densely	ADV
bjp-15259	109	14	mapped	map	VERB
bjp-15259	109	15	regions	region	NOUN
bjp-15259	109	16	identified	identify	VERB
bjp-15259	109	17	by	by	ADP
bjp-15259	109	18	genome	genome	NOUN
bjp-15259	109	19	-	-	PUNCT
bjp-15259	109	20	wide	wide	ADJ
bjp-15259	109	21	association	association	NOUN
bjp-15259	109	22	studies	study	NOUN
bjp-15259	109	23	,	,	PUNCT
bjp-15259	109	24	and	and	CCONJ
bjp-15259	109	25	analyzed	analyze	VERB
bjp-15259	109	26	natural	natural	ADJ
bjp-15259	109	27	selection	selection	NOUN
bjp-15259	109	28	of	of	ADP
bjp-15259	109	29	sequence	sequence	NOUN
bjp-15259	109	30	data	datum	NOUN
bjp-15259	109	31	,	,	PUNCT
bjp-15259	109	32	where	where	SCONJ
bjp-15259	109	33	even	even	ADV
bjp-15259	109	34	mildly	mildly	ADV
bjp-15259	109	35	deleterious	deleterious	ADJ
bjp-15259	109	36	alleles	allele	NOUN
bjp-15259	109	37	must	must	AUX
bjp-15259	109	38	be	be	AUX
bjp-15259	109	39	treated	treat	VERB
bjp-15259	109	40	as	as	ADP
bjp-15259	109	41	damaging	damaging	ADJ
bjp-15259	109	42	.	.	PUNCT
bjp-15259	110	1	polyphen-2	polyphen-2	PRON
bjp-15259	110	2	was	be	AUX
bjp-15259	110	3	reported	report	VERB
bjp-15259	110	4	to	to	PART
bjp-15259	110	5	achieve	achieve	VERB
bjp-15259	110	6	a	a	DET
bjp-15259	110	7	rate	rate	NOUN
bjp-15259	110	8	of	of	ADP
bjp-15259	110	9	true	true	ADJ
bjp-15259	110	10	positive	positive	ADJ
bjp-15259	110	11	predictions	prediction	NOUN
bjp-15259	110	12	of	of	ADP
bjp-15259	110	13	92	92	NUM
bjp-15259	110	14	%	%	NOUN
bjp-15259	110	15	(	(	PUNCT
bjp-15259	110	16	kumar	kumar	PROPN
bjp-15259	110	17	et	et	PROPN
bjp-15259	110	18	al	al	PROPN
bjp-15259	110	19	.	.	PROPN
bjp-15259	110	20	,	,	PUNCT
bjp-15259	110	21	2009	2009	NUM
bjp-15259	110	22	;	;	PUNCT
bjp-15259	110	23	capriotti	capriotti	NOUN
bjp-15259	110	24	et	et	PROPN
bjp-15259	110	25	al	al	PROPN
bjp-15259	110	26	.	.	PROPN
bjp-15259	110	27	,	,	PUNCT
bjp-15259	110	28	2008	2008	NUM
bjp-15259	110	29	;	;	PUNCT
bjp-15259	110	30	ivan	ivan	PROPN
bjp-15259	110	31	et	et	PROPN
bjp-15259	110	32	al	al	PROPN
bjp-15259	110	33	.	.	PROPN
bjp-15259	110	34	,	,	PUNCT
bjp-15259	110	35	2010	2010	NUM
bjp-15259	110	36	)	)	PUNCT
bjp-15259	110	37	.	.	PUNCT
bjp-15259	111	1	to	to	PART
bjp-15259	111	2	obtain	obtain	VERB
bjp-15259	111	3	precise	precise	ADJ
bjp-15259	111	4	and	and	CCONJ
bjp-15259	111	5	accurate	accurate	ADJ
bjp-15259	111	6	measures	measure	NOUN
bjp-15259	111	7	of	of	ADP
bjp-15259	111	8	the	the	DET
bjp-15259	111	9	detrimental	detrimental	ADJ
bjp-15259	111	10	effect	effect	NOUN
bjp-15259	111	11	of	of	ADP
bjp-15259	111	12	our	our	PRON
bjp-15259	111	13	variants	variant	NOUN
bjp-15259	111	14	,	,	PUNCT
bjp-15259	111	15	comprehensive	comprehensive	ADJ
bjp-15259	111	16	parameters	parameter	NOUN
bjp-15259	111	17	of	of	ADP
bjp-15259	111	18	all	all	DET
bjp-15259	111	19	these	these	DET
bjp-15259	111	20	three	three	NUM
bjp-15259	111	21	programs	program	NOUN
bjp-15259	111	22	could	could	AUX
bjp-15259	111	23	be	be	AUX
bjp-15259	111	24	more	more	ADV
bjp-15259	111	25	significant	significant	ADJ
bjp-15259	111	26	than	than	ADP
bjp-15259	111	27	individual	individual	ADJ
bjp-15259	111	28	tool	tool	NOUN
bjp-15259	111	29	parameters	parameter	NOUN
bjp-15259	111	30	.	.	PUNCT
bjp-15259	112	1	figure	figure	VERB
bjp-15259	112	2	1	1	NUM
bjp-15259	112	3	bangladesh	bangladesh	PROPN
bjp-15259	112	4	j	j	PROPN
bjp-15259	112	5	pharmacol	pharmacol	PROPN
bjp-15259	112	6	2013	2013	NUM
bjp-15259	112	7	;	;	PUNCT
bjp-15259	112	8	8	8	NUM
bjp-15259	112	9	:	:	PUNCT
bjp-15259	112	10	382	382	NUM
bjp-15259	112	11	-	-	SYM
bjp-15259	112	12	389	389	NUM
bjp-15259	112	13	385	385	NUM
bjp-15259	112	14	figure	figure	NOUN
bjp-15259	112	15	1	1	NUM
bjp-15259	112	16	:	:	PUNCT
bjp-15259	112	17	list	list	NOUN
bjp-15259	112	18	of	of	ADP
bjp-15259	112	19	functionally	functionally	ADV
bjp-15259	112	20	significant	significant	ADJ
bjp-15259	112	21	mutations	mutation	NOUN
bjp-15259	112	22	table	table	NOUN
bjp-15259	112	23	i	i	PRON
bjp-15259	112	24	list	list	NOUN
bjp-15259	112	25	of	of	ADP
bjp-15259	112	26	functionally	functionally	ADV
bjp-15259	112	27	significant	significant	ADJ
bjp-15259	112	28	mutants	mutant	NOUN
bjp-15259	112	29	predicted	predict	VERB
bjp-15259	112	30	to	to	PART
bjp-15259	112	31	be	be	AUX
bjp-15259	112	32	by	by	ADP
bjp-15259	112	33	i	i	NOUN
bjp-15259	112	34	-	-	PUNCT
bjp-15259	112	35	mutant	mutant	NOUN
bjp-15259	112	36	2.0	2.0	NUM
bjp-15259	112	37	,	,	PUNCT
bjp-15259	112	38	sift	sift	ADJ
bjp-15259	112	39	and	and	CCONJ
bjp-15259	112	40	polyphen	polyphen	ADV
bjp-15259	112	41	variant	variant	ADJ
bjp-15259	112	42	δδg	δδg	PROPN
bjp-15259	112	43	tolerance	tolerance	NOUN
bjp-15259	112	44	index	index	NOUN
bjp-15259	112	45	psic	psic	NOUN
bjp-15259	112	46	sd	sd	NOUN
bjp-15259	113	1	q36l	q36l	ADV
bjp-15259	113	2	-0.28	-0.28	NUM
bjp-15259	113	3	0	0	NUM
bjp-15259	113	4	3.096	3.096	NUM
bjp-15259	113	5	k41e	k41e	NOUN
bjp-15259	113	6	-2.61	-2.61	NOUN
bjp-15259	113	7	0.6	0.6	NUM
bjp-15259	113	8	0.13	0.13	NUM
bjp-15259	113	9	k41i	k41i	ADP
bjp-15259	113	10	-1.31	-1.31	NUM
bjp-15259	113	11	0.09	0.09	NUM
bjp-15259	113	12	1.873	1.873	NUM
bjp-15259	113	13	s52n	s52n	NUM
bjp-15259	113	14	-3.92	-3.92	ADJ
bjp-15259	113	15	0.5	0.5	NUM
bjp-15259	113	16	0.616	0.616	NUM
bjp-15259	113	17	r55k	r55k	NOUN
bjp-15259	113	18	-2.52	-2.52	NUM
bjp-15259	113	19	1	1	NUM
bjp-15259	113	20	0.174	0.174	NUM
bjp-15259	113	21	c63w	c63w	NUM
bjp-15259	113	22	-0.59	-0.59	NUM
bjp-15259	113	23	0	0	NUM
bjp-15259	113	24	4.091	4.091	NUM
bjp-15259	113	25	k64i	k64i	NOUN
bjp-15259	113	26	0.82	0.82	NUM
bjp-15259	113	27	0	0	NUM
bjp-15259	113	28	3.198	3.198	NUM
bjp-15259	113	29	i70v	i70v	NOUN
bjp-15259	113	30	-0.59	-0.59	NUM
bjp-15259	113	31	0.36	0.36	NUM
bjp-15259	113	32	0.259	0.259	NUM
bjp-15259	113	33	k84e	k84e	NOUN
bjp-15259	113	34	-0.89	-0.89	NUM
bjp-15259	113	35	0.63	0.63	NUM
bjp-15259	113	36	0.77	0.77	NUM
bjp-15259	113	37	p136l	p136l	NOUN
bjp-15259	113	38	0.67	0.67	NUM
bjp-15259	113	39	0	0	SYM
bjp-15259	113	40	3.436	3.436	NUM
bjp-15259	113	41	v137i	v137i	NOUN
bjp-15259	113	42	-0.19	-0.19	NOUN
bjp-15259	113	43	0.05	0.05	NUM
bjp-15259	113	44	0.988	0.988	NUM
bjp-15259	113	45	h138r	h138r	PROPN
bjp-15259	113	46	-1.16	-1.16	PROPN
bjp-15259	113	47	0	0	NUM
bjp-15259	113	48	3.419	3.419	NUM
bjp-15259	113	49	letters	letter	NOUN
bjp-15259	113	50	in	in	ADP
bjp-15259	113	51	bold	bold	ADJ
bjp-15259	113	52	indicate	indicate	VERB
bjp-15259	113	53	mutants	mutant	NOUN
bjp-15259	113	54	predicted	predict	VERB
bjp-15259	113	55	to	to	PART
bjp-15259	113	56	be	be	AUX
bjp-15259	113	57	less	less	ADV
bjp-15259	113	58	stable	stable	ADJ
bjp-15259	113	59	,	,	PUNCT
bjp-15259	113	60	deleterious	deleterious	ADJ
bjp-15259	113	61	and	and	CCONJ
bjp-15259	113	62	damaging	damaging	ADJ
bjp-15259	113	63	by	by	ADP
bjp-15259	113	64	i	i	PROPN
bjp-15259	113	65	-	-	PUNCT
bjp-15259	113	66	mutant2.0	mutant2.0	PROPN
bjp-15259	113	67	,	,	PUNCT
bjp-15259	113	68	sift	sift	VERB
bjp-15259	113	69	and	and	CCONJ
bjp-15259	113	70	polyphen	polyphen	ADV
bjp-15259	113	71	respectively	respectively	ADV
bjp-15259	113	72	shows	show	VERB
bjp-15259	113	73	the	the	DET
bjp-15259	113	74	pie	pie	NOUN
bjp-15259	113	75	chart	chart	NOUN
bjp-15259	113	76	distribution	distribution	NOUN
bjp-15259	113	77	of	of	ADP
bjp-15259	113	78	functionally	functionally	ADV
bjp-15259	113	79	significant	significant	ADJ
bjp-15259	113	80	mutations	mutation	NOUN
bjp-15259	113	81	based	base	VERB
bjp-15259	113	82	on	on	ADP
bjp-15259	113	83	sift	sift	ADJ
bjp-15259	113	84	,	,	PUNCT
bjp-15259	113	85	polyphen	polyphen	ADV
bjp-15259	113	86	and	and	CCONJ
bjp-15259	113	87	imutant2.0	imutant2.0	NUM
bjp-15259	113	88	.	.	PUNCT
bjp-15259	114	1	hence	hence	ADV
bjp-15259	114	2	,	,	PUNCT
bjp-15259	114	3	we	we	PRON
bjp-15259	114	4	further	far	ADV
bjp-15259	114	5	investigated	investigate	VERB
bjp-15259	114	6	these	these	DET
bjp-15259	114	7	detrimental	detrimental	ADJ
bjp-15259	114	8	missense	missense	NOUN
bjp-15259	114	9	mutations	mutation	NOUN
bjp-15259	114	10	by	by	ADP
bjp-15259	114	11	structural	structural	ADJ
bjp-15259	114	12	analysis	analysis	NOUN
bjp-15259	114	13	.	.	PUNCT
bjp-15259	115	1	mapping	map	VERB
bjp-15259	115	2	the	the	DET
bjp-15259	115	3	3	3	NUM
bjp-15259	115	4	variants	variant	NOUN
bjp-15259	115	5	namely	namely	ADV
bjp-15259	115	6	,	,	PUNCT
bjp-15259	115	7	q36l	q36l	PROPN
bjp-15259	115	8	,	,	PUNCT
bjp-15259	115	9	c63w	c63w	PROPN
bjp-15259	115	10	and	and	CCONJ
bjp-15259	115	11	h138r	h138r	PROPN
bjp-15259	115	12	into	into	ADP
bjp-15259	115	13	the	the	DET
bjp-15259	115	14	structural	structural	ADJ
bjp-15259	115	15	information	information	NOUN
bjp-15259	115	16	of	of	ADP
bjp-15259	115	17	protein	protein	NOUN
bjp-15259	115	18	angiogenin	angiogenin	NOUN
bjp-15259	115	19	was	be	AUX
bjp-15259	115	20	retrieved	retrieve	VERB
bjp-15259	115	21	from	from	ADP
bjp-15259	115	22	saapdb	saapdb	NOUN
bjp-15259	115	23	.	.	PUNCT
bjp-15259	116	1	the	the	DET
bjp-15259	116	2	structure	structure	NOUN
bjp-15259	116	3	accessible	accessible	ADJ
bjp-15259	116	4	for	for	ADP
bjp-15259	116	5	angiogenin	angiogenin	NOUN
bjp-15259	116	6	protein	protein	NOUN
bjp-15259	116	7	referred	refer	VERB
bjp-15259	116	8	a	a	DET
bjp-15259	116	9	pdb	pdb	NOUN
bjp-15259	116	10	i	i	PROPN
bjp-15259	116	11	d	d	PROPN
bjp-15259	116	12	of	of	ADP
bjp-15259	116	13	2ang	2ang	PROPN
bjp-15259	116	14	.	.	PUNCT
bjp-15259	117	1	the	the	DET
bjp-15259	117	2	mutational	mutational	ADJ
bjp-15259	117	3	position	position	NOUN
bjp-15259	117	4	and	and	CCONJ
bjp-15259	117	5	amino	amino	NOUN
bjp-15259	117	6	acid	acid	NOUN
bjp-15259	117	7	variants	variant	NOUN
bjp-15259	117	8	were	be	AUX
bjp-15259	117	9	mapped	map	VERB
bjp-15259	117	10	in	in	ADP
bjp-15259	117	11	the	the	DET
bjp-15259	117	12	native	native	ADJ
bjp-15259	117	13	structure	structure	NOUN
bjp-15259	117	14	.	.	PUNCT
bjp-15259	118	1	mutation	mutation	NOUN
bjp-15259	118	2	at	at	ADP
bjp-15259	118	3	specified	specified	ADJ
bjp-15259	118	4	position	position	NOUN
bjp-15259	118	5	was	be	AUX
bjp-15259	118	6	done	do	VERB
bjp-15259	118	7	by	by	ADP
bjp-15259	118	8	swisspdb	swisspdb	PROPN
bjp-15259	118	9	viewer	viewer	NOUN
bjp-15259	118	10	independently	independently	ADV
bjp-15259	118	11	to	to	PART
bjp-15259	118	12	obtain	obtain	VERB
bjp-15259	118	13	modeled	model	VERB
bjp-15259	118	14	structures	structure	NOUN
bjp-15259	118	15	.	.	PUNCT
bjp-15259	119	1	the	the	DET
bjp-15259	119	2	energy	energy	NOUN
bjp-15259	119	3	minimization	minimization	NOUN
bjp-15259	119	4	was	be	AUX
bjp-15259	119	5	then	then	ADV
bjp-15259	119	6	performed	perform	VERB
bjp-15259	119	7	by	by	ADP
bjp-15259	119	8	the	the	DET
bjp-15259	119	9	nomad	nomad	NOUN
bjp-15259	119	10	ref	ref	NOUN
bjp-15259	119	11	server	server	NOUN
bjp-15259	119	12	for	for	ADP
bjp-15259	119	13	both	both	CCONJ
bjp-15259	119	14	the	the	DET
bjp-15259	119	15	native	native	ADJ
bjp-15259	119	16	structure	structure	NOUN
bjp-15259	119	17	(	(	PUNCT
bjp-15259	119	18	pdb	pdb	PROPN
bjp-15259	119	19	2ang	2ang	PROPN
bjp-15259	119	20	)	)	PUNCT
bjp-15259	119	21	and	and	CCONJ
bjp-15259	119	22	mutant	mutant	ADJ
bjp-15259	119	23	modeled	model	VERB
bjp-15259	119	24	structures	structure	NOUN
bjp-15259	119	25	.	.	PUNCT
bjp-15259	120	1	in	in	ADP
bjp-15259	120	2	order	order	NOUN
bjp-15259	120	3	to	to	PART
bjp-15259	120	4	find	find	VERB
bjp-15259	120	5	out	out	ADP
bjp-15259	120	6	the	the	DET
bjp-15259	120	7	structural	structural	ADJ
bjp-15259	120	8	stability	stability	NOUN
bjp-15259	120	9	for	for	ADP
bjp-15259	120	10	angiogenin	angiogenin	NOUN
bjp-15259	120	11	of	of	ADP
bjp-15259	120	12	native	native	ADJ
bjp-15259	120	13	and	and	CCONJ
bjp-15259	120	14	mutants	mutant	NOUN
bjp-15259	120	15	,	,	PUNCT
bjp-15259	120	16	we	we	PRON
bjp-15259	120	17	computed	compute	VERB
bjp-15259	120	18	the	the	DET
bjp-15259	120	19	total	total	ADJ
bjp-15259	120	20	energy	energy	NOUN
bjp-15259	120	21	,	,	PUNCT
bjp-15259	120	22	which	which	PRON
bjp-15259	120	23	included	include	VERB
bjp-15259	120	24	bonds	bond	NOUN
bjp-15259	120	25	,	,	PUNCT
bjp-15259	120	26	angles	angle	NOUN
bjp-15259	120	27	,	,	PUNCT
bjp-15259	120	28	and	and	CCONJ
bjp-15259	120	29	torsions	torsion	NOUN
bjp-15259	120	30	,	,	PUNCT
bjp-15259	120	31	non	non	ADJ
bjp-15259	120	32	-	-	ADJ
bjp-15259	120	33	bonded	bonded	ADJ
bjp-15259	120	34	and	and	CCONJ
bjp-15259	120	35	electrostatic	electrostatic	ADJ
bjp-15259	120	36	constraints	constraint	NOUN
bjp-15259	120	37	from	from	ADP
bjp-15259	120	38	gromos	gromos	PROPN
bjp-15259	120	39	96	96	NUM
bjp-15259	120	40	force	force	NOUN
bjp-15259	120	41	field	field	NOUN
bjp-15259	120	42	implemented	implement	VERB
bjp-15259	120	43	in	in	ADP
bjp-15259	120	44	deepview	deepview	NOUN
bjp-15259	120	45	to	to	PART
bjp-15259	120	46	check	check	VERB
bjp-15259	120	47	their	their	PRON
bjp-15259	120	48	stability	stability	NOUN
bjp-15259	120	49	.	.	PUNCT
bjp-15259	121	1	table	table	NOUN
bjp-15259	121	2	ii	ii	PROPN
bjp-15259	121	3	showed	show	VERB
bjp-15259	121	4	that	that	SCONJ
bjp-15259	121	5	the	the	DET
bjp-15259	121	6	total	total	ADJ
bjp-15259	121	7	energy	energy	NOUN
bjp-15259	121	8	of	of	ADP
bjp-15259	121	9	the	the	DET
bjp-15259	121	10	native	native	ADJ
bjp-15259	121	11	protein	protein	NOUN
bjp-15259	121	12	had	have	VERB
bjp-15259	121	13	10091.175kj	10091.175kj	ADJ
bjp-15259	121	14	/	/	SYM
bjp-15259	121	15	mol	mol	NOUN
bjp-15259	121	16	whereas	whereas	SCONJ
bjp-15259	121	17	the	the	DET
bjp-15259	121	18	3	3	NUM
bjp-15259	121	19	mutants	mutant	NOUN
bjp-15259	121	20	had	have	VERB
bjp-15259	121	21	greater	great	ADJ
bjp-15259	121	22	total	total	ADJ
bjp-15259	121	23	energy	energy	NOUN
bjp-15259	121	24	than	than	ADP
bjp-15259	121	25	the	the	DET
bjp-15259	121	26	native	native	ADJ
bjp-15259	121	27	protein	protein	NOUN
bjp-15259	121	28	.	.	PUNCT
bjp-15259	122	1	the	the	PRON
bjp-15259	122	2	higher	high	ADJ
bjp-15259	122	3	the	the	DET
bjp-15259	122	4	total	total	ADJ
bjp-15259	122	5	energy	energy	NOUN
bjp-15259	122	6	,	,	PUNCT
bjp-15259	122	7	lesser	less	ADJ
bjp-15259	122	8	would	would	AUX
bjp-15259	122	9	be	be	AUX
bjp-15259	122	10	the	the	DET
bjp-15259	122	11	protein	protein	NOUN
bjp-15259	122	12	structure	structure	NOUN
bjp-15259	122	13	stability	stability	NOUN
bjp-15259	122	14	.	.	PUNCT
bjp-15259	123	1	the	the	DET
bjp-15259	123	2	native	native	ADJ
bjp-15259	123	3	structure	structure	NOUN
bjp-15259	123	4	(	(	PUNCT
bjp-15259	123	5	pdb	pdb	PROPN
bjp-15259	123	6	2ang	2ang	PROPN
bjp-15259	123	7	)	)	PUNCT
bjp-15259	123	8	was	be	AUX
bjp-15259	123	9	superimposed	superimpose	VERB
bjp-15259	123	10	with	with	ADP
bjp-15259	123	11	all	all	DET
bjp-15259	123	12	the	the	DET
bjp-15259	123	13	mutant	mutant	ADJ
bjp-15259	123	14	modeled	model	VERB
bjp-15259	123	15	structures	structure	NOUN
bjp-15259	123	16	and	and	CCONJ
bjp-15259	123	17	rmsd	rmsd	NOUN
bjp-15259	123	18	calculated	calculate	VERB
bjp-15259	123	19	to	to	PART
bjp-15259	123	20	find	find	VERB
bjp-15259	123	21	the	the	DET
bjp-15259	123	22	deviation	deviation	NOUN
bjp-15259	123	23	between	between	ADP
bjp-15259	123	24	the	the	DET
bjp-15259	123	25	two	two	NUM
bjp-15259	123	26	structures	structure	NOUN
bjp-15259	123	27	.	.	PUNCT
bjp-15259	124	1	the	the	PRON
bjp-15259	124	2	higher	high	ADJ
bjp-15259	124	3	the	the	DET
bjp-15259	124	4	rmsd	rmsd	NOUN
bjp-15259	124	5	value	value	NOUN
bjp-15259	124	6	,	,	PUNCT
bjp-15259	124	7	greater	great	ADJ
bjp-15259	124	8	was	be	AUX
bjp-15259	124	9	the	the	DET
bjp-15259	124	10	deviation	deviation	NOUN
bjp-15259	124	11	between	between	ADP
bjp-15259	124	12	the	the	DET
bjp-15259	124	13	native	native	ADJ
bjp-15259	124	14	and	and	CCONJ
bjp-15259	124	15	mutant	mutant	ADJ
bjp-15259	124	16	structure	structure	NOUN
bjp-15259	124	17	and	and	CCONJ
bjp-15259	124	18	this	this	DET
bjp-15259	124	19	consecutively	consecutively	ADV
bjp-15259	124	20	change	change	VERB
bjp-15259	124	21	the	the	DET
bjp-15259	124	22	binding	bind	VERB
bjp-15259	124	23	efficiency	efficiency	NOUN
bjp-15259	124	24	towards	towards	ADP
bjp-15259	124	25	its	its	PRON
bjp-15259	124	26	interacting	interact	VERB
bjp-15259	124	27	partners	partner	NOUN
bjp-15259	124	28	owing	owe	VERB
bjp-15259	124	29	to	to	ADP
bjp-15259	124	30	deviation	deviation	NOUN
bjp-15259	124	31	in	in	ADP
bjp-15259	124	32	the	the	DET
bjp-15259	124	33	three	three	NUM
bjp-15259	124	34	dimensional	dimensional	ADJ
bjp-15259	124	35	space	space	NOUN
bjp-15259	124	36	of	of	ADP
bjp-15259	124	37	the	the	DET
bjp-15259	124	38	binding	bind	VERB
bjp-15259	124	39	residues	residue	NOUN
bjp-15259	124	40	of	of	ADP
bjp-15259	124	41	angiogenin	angiogenin	NOUN
bjp-15259	124	42	.	.	PUNCT
bjp-15259	125	1	rmsd	rmsd	ADJ
bjp-15259	125	2	values	value	NOUN
bjp-15259	125	3	for	for	ADP
bjp-15259	125	4	native	native	ADJ
bjp-15259	125	5	structure	structure	NOUN
bjp-15259	125	6	with	with	ADP
bjp-15259	125	7	all	all	DET
bjp-15259	125	8	the	the	DET
bjp-15259	125	9	mutant	mutant	ADJ
bjp-15259	125	10	modeled	model	VERB
bjp-15259	125	11	structures	structure	NOUN
bjp-15259	125	12	were	be	AUX
bjp-15259	125	13	shown	show	VERB
bjp-15259	125	14	in	in	ADP
bjp-15259	125	15	table	table	NOUN
bjp-15259	125	16	ii	ii	PROPN
bjp-15259	125	17	.	.	PUNCT
bjp-15259	126	1	thus	thus	ADV
bjp-15259	126	2	,	,	PUNCT
bjp-15259	126	3	table	table	NOUN
bjp-15259	126	4	ii	ii	PROPN
bjp-15259	126	5	confirmed	confirm	VERB
bjp-15259	126	6	that	that	SCONJ
bjp-15259	126	7	,	,	PUNCT
bjp-15259	126	8	all	all	DET
bjp-15259	126	9	the	the	DET
bjp-15259	126	10	3	3	NUM
bjp-15259	126	11	mutants	mutant	NOUN
bjp-15259	126	12	displayed	display	VERB
bjp-15259	126	13	an	an	DET
bjp-15259	126	14	rmsd	rmsd	ADJ
bjp-15259	126	15	value	value	NOUN
bjp-15259	126	16	≥1.37å	≥1.37å	PUNCT
bjp-15259	126	17	.	.	PUNCT
bjp-15259	127	1	figure	figure	NOUN
bjp-15259	127	2	2	2	NUM
bjp-15259	127	3	showed	show	VERB
bjp-15259	127	4	the	the	DET
bjp-15259	127	5	super	super	ADV
bjp-15259	127	6	imposed	impose	VERB
bjp-15259	127	7	structures	structure	NOUN
bjp-15259	127	8	of	of	ADP
bjp-15259	127	9	native	native	ADJ
bjp-15259	127	10	with	with	ADP
bjp-15259	127	11	mutants	mutant	NOUN
bjp-15259	127	12	(	(	PUNCT
bjp-15259	127	13	a	a	NOUN
bjp-15259	127	14	)	)	PUNCT
bjp-15259	127	15	q36l	q36l	PROPN
bjp-15259	127	16	,	,	PUNCT
bjp-15259	127	17	(	(	PUNCT
bjp-15259	127	18	b	b	X
bjp-15259	127	19	)	)	PUNCT
bjp-15259	127	20	c63w	c63w	PROPN
bjp-15259	127	21	and	and	CCONJ
bjp-15259	127	22	(	(	PUNCT
bjp-15259	127	23	c	c	NOUN
bjp-15259	127	24	)	)	PUNCT
bjp-15259	127	25	h138r	h138r	PROPN
bjp-15259	127	26	.	.	PUNCT
bjp-15259	128	1	we	we	PRON
bjp-15259	128	2	further	far	ADV
bjp-15259	128	3	validated	validate	VERB
bjp-15259	128	4	the	the	DET
bjp-15259	128	5	stability	stability	NOUN
bjp-15259	128	6	of	of	ADP
bjp-15259	128	7	protein	protein	NOUN
bjp-15259	128	8	structure	structure	NOUN
bjp-15259	128	9	by	by	ADP
bjp-15259	128	10	using	use	VERB
bjp-15259	128	11	the	the	DET
bjp-15259	128	12	pic	pic	NOUN
bjp-15259	128	13	server	server	NOUN
bjp-15259	128	14	to	to	PART
bjp-15259	128	15	identify	identify	VERB
bjp-15259	128	16	the	the	DET
bjp-15259	128	17	number	number	NOUN
bjp-15259	128	18	of	of	ADP
bjp-15259	128	19	intramolecular	intramolecular	ADJ
bjp-15259	128	20	interactions	interaction	NOUN
bjp-15259	128	21	of	of	ADP
bjp-15259	128	22	both	both	CCONJ
bjp-15259	128	23	the	the	DET
bjp-15259	128	24	native	native	ADJ
bjp-15259	128	25	and	and	CCONJ
bjp-15259	128	26	mutant	mutant	ADJ
bjp-15259	128	27	structures	structure	NOUN
bjp-15259	128	28	.	.	PUNCT
bjp-15259	129	1	to	to	PART
bjp-15259	129	2	understand	understand	VERB
bjp-15259	129	3	the	the	DET
bjp-15259	129	4	molecular	molecular	ADJ
bjp-15259	129	5	root	root	NOUN
bjp-15259	129	6	of	of	ADP
bjp-15259	129	7	stability	stability	NOUN
bjp-15259	129	8	,	,	PUNCT
bjp-15259	129	9	functions	function	NOUN
bjp-15259	129	10	and	and	CCONJ
bjp-15259	129	11	the	the	DET
bjp-15259	129	12	complexes	complex	NOUN
bjp-15259	129	13	of	of	ADP
bjp-15259	129	14	protein	protein	NOUN
bjp-15259	129	15	,	,	PUNCT
bjp-15259	129	16	the	the	DET
bjp-15259	129	17	intra	intra	ADJ
bjp-15259	129	18	protein	protein	NOUN
bjp-15259	129	19	structure	structure	NOUN
bjp-15259	129	20	interactions	interaction	NOUN
bjp-15259	129	21	and	and	CCONJ
bjp-15259	129	22	the	the	DET
bjp-15259	129	23	inter	inter	ADJ
bjp-15259	129	24	protein	protein	NOUN
bjp-15259	129	25	structure	structure	NOUN
bjp-15259	129	26	interactions	interaction	NOUN
bjp-15259	129	27	in	in	ADP
bjp-15259	129	28	a	a	DET
bjp-15259	129	29	congregation	congregation	NOUN
bjp-15259	129	30	were	be	AUX
bjp-15259	129	31	considered	consider	VERB
bjp-15259	129	32	important	important	ADJ
bjp-15259	129	33	.	.	PUNCT
bjp-15259	130	1	several	several	ADJ
bjp-15259	130	2	weak	weak	ADJ
bjp-15259	130	3	and	and	CCONJ
bjp-15259	130	4	strong	strong	ADJ
bjp-15259	130	5	intra	intra	ADJ
bjp-15259	130	6	-	-	ADJ
bjp-15259	130	7	molecular	molecular	ADJ
bjp-15259	130	8	interactions	interaction	NOUN
bjp-15259	130	9	that	that	PRON
bjp-15259	130	10	render	render	VERB
bjp-15259	130	11	stability	stability	NOUN
bjp-15259	130	12	of	of	ADP
bjp-15259	130	13	a	a	DET
bjp-15259	130	14	protein	protein	NOUN
bjp-15259	130	15	structure	structure	NOUN
bjp-15259	130	16	were	be	AUX
bjp-15259	130	17	studied	study	VERB
bjp-15259	130	18	.	.	PUNCT
bjp-15259	131	1	therefore	therefore	ADV
bjp-15259	131	2	these	these	DET
bjp-15259	131	3	intra	intra	ADJ
bjp-15259	131	4	-	-	ADJ
bjp-15259	131	5	molecular	molecular	ADJ
bjp-15259	131	6	interactions	interaction	NOUN
bjp-15259	131	7	were	be	AUX
bjp-15259	131	8	computed	compute	VERB
bjp-15259	131	9	by	by	ADP
bjp-15259	131	10	the	the	DET
bjp-15259	131	11	pic	pic	NOUN
bjp-15259	131	12	server	server	NOUN
bjp-15259	131	13	in	in	ADP
bjp-15259	131	14	order	order	NOUN
bjp-15259	131	15	to	to	PART
bjp-15259	131	16	additionally	additionally	ADV
bjp-15259	131	17	validate	validate	VERB
bjp-15259	131	18	the	the	DET
bjp-15259	131	19	protein	protein	NOUN
bjp-15259	131	20	structure	structure	NOUN
bjp-15259	131	21	stability	stability	NOUN
bjp-15259	131	22	.	.	PUNCT
bjp-15259	132	1	regarding	regard	VERB
bjp-15259	132	2	this	this	DET
bjp-15259	132	3	investigation	investigation	NOUN
bjp-15259	132	4	,	,	PUNCT
bjp-15259	132	5	it	it	PRON
bjp-15259	132	6	was	be	AUX
bjp-15259	132	7	observed	observe	VERB
bjp-15259	132	8	that	that	SCONJ
bjp-15259	132	9	totally	totally	ADV
bjp-15259	132	10	392	392	NUM
bjp-15259	132	11	intra	intra	ADJ
bjp-15259	132	12	-	-	ADJ
bjp-15259	132	13	molecular	molecular	ADJ
bjp-15259	132	14	interactions	interaction	NOUN
bjp-15259	132	15	were	be	AUX
bjp-15259	132	16	obtained	obtain	VERB
bjp-15259	132	17	in	in	ADP
bjp-15259	132	18	the	the	DET
bjp-15259	132	19	native	native	ADJ
bjp-15259	132	20	structure	structure	NOUN
bjp-15259	132	21	of	of	ADP
bjp-15259	132	22	angiogenin	angiogenin	NOUN
bjp-15259	132	23	.	.	PUNCT
bjp-15259	133	1	on	on	ADP
bjp-15259	133	2	the	the	DET
bjp-15259	133	3	other	other	ADJ
bjp-15259	133	4	hand	hand	NOUN
bjp-15259	133	5	,	,	PUNCT
bjp-15259	133	6	3	3	NUM
bjp-15259	133	7	mutant	mutant	ADJ
bjp-15259	133	8	structures	structure	NOUN
bjp-15259	133	9	of	of	ADP
bjp-15259	133	10	angiogenin	angiogenin	NOUN
bjp-15259	133	11	established	establish	VERB
bjp-15259	133	12	the	the	DET
bjp-15259	133	13	intramolecular	intramolecular	ADJ
bjp-15259	133	14	interactions	interaction	NOUN
bjp-15259	133	15	between	between	ADP
bjp-15259	133	16	the	the	DET
bjp-15259	133	17	range	range	NOUN
bjp-15259	133	18	of	of	ADP
bjp-15259	133	19	358	358	NUM
bjp-15259	133	20	to	to	ADP
bjp-15259	133	21	385	385	NUM
bjp-15259	133	22	as	as	SCONJ
bjp-15259	133	23	shown	show	VERB
bjp-15259	133	24	in	in	ADP
bjp-15259	133	25	table	table	NOUN
bjp-15259	133	26	ii	ii	PROPN
bjp-15259	133	27	.	.	PUNCT
bjp-15259	134	1	we	we	PRON
bjp-15259	134	2	further	far	ADV
bjp-15259	134	3	evaluated	evaluate	VERB
bjp-15259	134	4	the	the	DET
bjp-15259	134	5	effect	effect	NOUN
bjp-15259	134	6	of	of	ADP
bjp-15259	134	7	these	these	DET
bjp-15259	134	8	3	3	NUM
bjp-15259	134	9	detrimental	detrimental	ADJ
bjp-15259	134	10	missense	missense	NOUN
bjp-15259	134	11	mutations	mutation	NOUN
bjp-15259	134	12	by	by	ADP
bjp-15259	134	13	performing	perform	VERB
bjp-15259	134	14	binding	bind	VERB
bjp-15259	134	15	analysis	analysis	NOUN
bjp-15259	134	16	between	between	ADP
bjp-15259	134	17	angiogenin	angiogenin	NOUN
bjp-15259	134	18	and	and	CCONJ
bjp-15259	134	19	ribonuclease	ribonuclease	NOUN
bjp-15259	134	20	386	386	NUM
bjp-15259	134	21	bangladesh	bangladesh	NOUN
bjp-15259	134	22	j	j	PROPN
bjp-15259	134	23	pharmacol	pharmacol	PROPN
bjp-15259	134	24	2013	2013	NUM
bjp-15259	134	25	;	;	PUNCT
bjp-15259	134	26	8	8	NUM
bjp-15259	134	27	:	:	PUNCT
bjp-15259	134	28	382	382	NUM
bjp-15259	134	29	-	-	SYM
bjp-15259	134	30	389	389	NUM
bjp-15259	134	31	table	table	NOUN
bjp-15259	134	32	ii	ii	NOUN
bjp-15259	134	33	rmsd	rmsd	NOUN
bjp-15259	134	34	,	,	PUNCT
bjp-15259	134	35	total	total	ADJ
bjp-15259	134	36	energy	energy	NOUN
bjp-15259	134	37	,	,	PUNCT
bjp-15259	134	38	number	number	NOUN
bjp-15259	134	39	of	of	ADP
bjp-15259	134	40	intramolecular	intramolecular	ADJ
bjp-15259	134	41	interactions	interaction	NOUN
bjp-15259	134	42	and	and	CCONJ
bjp-15259	134	43	free	free	ADJ
bjp-15259	134	44	energy	energy	NOUN
bjp-15259	134	45	for	for	ADP
bjp-15259	134	46	the	the	DET
bjp-15259	134	47	native	native	ADJ
bjp-15259	134	48	protein	protein	NOUN
bjp-15259	134	49	and	and	CCONJ
bjp-15259	134	50	mutants	mutant	NOUN
bjp-15259	134	51	variant	variant	NOUN
bjp-15259	134	52	rmsd	rmsd	NOUN
bjp-15259	134	53	(	(	PUNCT
bjp-15259	134	54	å	å	NOUN
bjp-15259	134	55	)	)	PUNCT
bjp-15259	134	56	total	total	ADJ
bjp-15259	134	57	energy	energy	NOUN
bjp-15259	134	58	(	(	PUNCT
bjp-15259	134	59	kj	kj	PROPN
bjp-15259	134	60	/	/	SYM
bjp-15259	134	61	mol	mol	PROPN
bjp-15259	134	62	)	)	PUNCT
bjp-15259	134	63	total	total	ADJ
bjp-15259	134	64	number	number	NOUN
bjp-15259	134	65	of	of	ADP
bjp-15259	134	66	intramolecular	intramolecular	ADJ
bjp-15259	134	67	interactions	interaction	NOUN
bjp-15259	134	68	free	free	ADJ
bjp-15259	134	69	energy	energy	NOUN
bjp-15259	134	70	(	(	PUNCT
bjp-15259	134	71	kcal	kcal	NOUN
bjp-15259	134	72	/	/	SYM
bjp-15259	134	73	mol	mol	NOUN
bjp-15259	134	74	)	)	PUNCT
bjp-15259	134	75	native	native	ADJ
bjp-15259	134	76	0.00	0.00	NUM
bjp-15259	134	77	å	å	PROPN
bjp-15259	134	78	-10091.175	-10091.175	PUNCT
bjp-15259	134	79	392	392	NUM
bjp-15259	134	80	-1215.59	-1215.59	VERB
bjp-15259	134	81	q36l	q36l	PROPN
bjp-15259	134	82	1.27	1.27	NUM
bjp-15259	134	83	å	å	NOUN
bjp-15259	134	84	-9249.535	-9249.535	NUM
bjp-15259	134	85	385	385	NUM
bjp-15259	134	86	-1203.83	-1203.83	NUM
bjp-15259	134	87	c63w	c63w	NUM
bjp-15259	134	88	1.37	1.37	NUM
bjp-15259	134	89	å	å	PROPN
bjp-15259	134	90	-9434.581	-9434.581	NUM
bjp-15259	134	91	385	385	NUM
bjp-15259	134	92	-1202.48	-1202.48	PROPN
bjp-15259	134	93	h138r	h138r	PROPN
bjp-15259	134	94	1.20	1.20	NUM
bjp-15259	134	95	å	å	PROPN
bjp-15259	134	96	-9677.100	-9677.100	PUNCT
bjp-15259	134	97	358	358	NUM
bjp-15259	134	98	-1198.17	-1198.17	PROPN
bjp-15259	134	99	rmsd	rmsd	X
bjp-15259	134	100	(	(	PUNCT
bjp-15259	134	101	root	root	NOUN
bjp-15259	134	102	mean	mean	ADJ
bjp-15259	134	103	square	square	ADJ
bjp-15259	134	104	deviation	deviation	NOUN
bjp-15259	134	105	)	)	PUNCT
bjp-15259	134	106	,	,	PUNCT
bjp-15259	134	107	total	total	ADJ
bjp-15259	134	108	energy	energy	NOUN
bjp-15259	134	109	,	,	PUNCT
bjp-15259	134	110	total	total	ADJ
bjp-15259	134	111	number	number	NOUN
bjp-15259	134	112	of	of	ADP
bjp-15259	134	113	intra	intra	ADJ
bjp-15259	134	114	-	-	ADJ
bjp-15259	134	115	molecular	molecular	ADJ
bjp-15259	134	116	interactions	interaction	NOUN
bjp-15259	134	117	and	and	CCONJ
bjp-15259	134	118	free	free	ADJ
bjp-15259	134	119	energy	energy	NOUN
bjp-15259	134	120	figure	figure	NOUN
bjp-15259	134	121	2	2	NUM
bjp-15259	134	122	:	:	PUNCT
bjp-15259	134	123	superimposed	superimpose	VERB
bjp-15259	134	124	structure	structure	NOUN
bjp-15259	134	125	of	of	ADP
bjp-15259	134	126	the	the	DET
bjp-15259	134	127	native	native	ADJ
bjp-15259	134	128	protein	protein	NOUN
bjp-15259	134	129	(	(	PUNCT
bjp-15259	134	130	green	green	ADJ
bjp-15259	134	131	)	)	PUNCT
bjp-15259	134	132	with	with	ADP
bjp-15259	134	133	mutant	mutant	NOUN
bjp-15259	134	134	(	(	PUNCT
bjp-15259	134	135	a	a	NOUN
bjp-15259	134	136	)	)	PUNCT
bjp-15259	134	137	superimposed	superimposed	ADJ
bjp-15259	134	138	structure	structure	NOUN
bjp-15259	134	139	of	of	ADP
bjp-15259	134	140	native	native	ADJ
bjp-15259	134	141	angiogenin	angiogenin	PROPN
bjp-15259	134	142	(	(	PUNCT
bjp-15259	134	143	green	green	ADJ
bjp-15259	134	144	)	)	PUNCT
bjp-15259	134	145	with	with	ADP
bjp-15259	134	146	mutant	mutant	ADJ
bjp-15259	134	147	q36l	q36l	PROPN
bjp-15259	134	148	(	(	PUNCT
bjp-15259	134	149	red	red	ADJ
bjp-15259	134	150	)	)	PUNCT
bjp-15259	134	151	structure	structure	NOUN
bjp-15259	134	152	showing	show	VERB
bjp-15259	134	153	rmsd	rmsd	NOUN
bjp-15259	134	154	of	of	ADP
bjp-15259	134	155	1.27	1.27	NUM
bjp-15259	134	156	ǻ	ǻ	NOUN
bjp-15259	134	157	.	.	PUNCT
bjp-15259	135	1	(	(	PUNCT
bjp-15259	135	2	b	b	X
bjp-15259	135	3	)	)	PUNCT
bjp-15259	135	4	superimposed	superimpose	VERB
bjp-15259	135	5	structure	structure	NOUN
bjp-15259	135	6	of	of	ADP
bjp-15259	135	7	native	native	ADJ
bjp-15259	135	8	angiogenin	angiogenin	PROPN
bjp-15259	135	9	(	(	PUNCT
bjp-15259	135	10	green	green	ADJ
bjp-15259	135	11	)	)	PUNCT
bjp-15259	135	12	with	with	ADP
bjp-15259	135	13	mutant	mutant	ADJ
bjp-15259	135	14	c63w	c63w	PROPN
bjp-15259	135	15	(	(	PUNCT
bjp-15259	135	16	blue	blue	ADJ
bjp-15259	135	17	)	)	PUNCT
bjp-15259	135	18	structure	structure	NOUN
bjp-15259	135	19	showing	show	VERB
bjp-15259	135	20	rmsd	rmsd	NOUN
bjp-15259	135	21	of	of	ADP
bjp-15259	135	22	1.37	1.37	NUM
bjp-15259	135	23	ǻ	ǻ	NOUN
bjp-15259	135	24	.	.	PUNCT
bjp-15259	136	1	(	(	PUNCT
bjp-15259	136	2	c	c	X
bjp-15259	136	3	)	)	PUNCT
bjp-15259	136	4	superimposed	superimpose	VERB
bjp-15259	136	5	structure	structure	NOUN
bjp-15259	136	6	of	of	ADP
bjp-15259	136	7	native	native	ADJ
bjp-15259	136	8	angiogenin	angiogenin	PROPN
bjp-15259	136	9	(	(	PUNCT
bjp-15259	136	10	green	green	ADJ
bjp-15259	136	11	)	)	PUNCT
bjp-15259	136	12	with	with	ADP
bjp-15259	136	13	mutant	mutant	ADJ
bjp-15259	136	14	h138r	h138r	PROPN
bjp-15259	136	15	(	(	PUNCT
bjp-15259	136	16	magenta	magenta	NOUN
bjp-15259	136	17	)	)	PUNCT
bjp-15259	136	18	structure	structure	NOUN
bjp-15259	136	19	showing	show	VERB
bjp-15259	136	20	rmsd	rmsd	NOUN
bjp-15259	136	21	of	of	ADP
bjp-15259	136	22	1.20	1.20	NUM
bjp-15259	136	23	ǻ	ǻ	NOUN
bjp-15259	136	24	.	.	PUNCT
bjp-15259	137	1	a	a	DET
bjp-15259	137	2	b	b	PROPN
bjp-15259	137	3	c	c	PROPN
bjp-15259	137	4	inhibitor	inhibitor	NOUN
bjp-15259	137	5	complex	complex	NOUN
bjp-15259	137	6	through	through	ADP
bjp-15259	137	7	protein	protein	NOUN
bjp-15259	137	8	-	-	PUNCT
bjp-15259	137	9	protein	protein	NOUN
bjp-15259	137	10	docking	docking	NOUN
bjp-15259	137	11	studies	study	NOUN
bjp-15259	137	12	in	in	ADP
bjp-15259	137	13	order	order	NOUN
bjp-15259	137	14	to	to	PART
bjp-15259	137	15	understand	understand	VERB
bjp-15259	137	16	the	the	DET
bjp-15259	137	17	functional	functional	ADJ
bjp-15259	137	18	activity	activity	NOUN
bjp-15259	137	19	of	of	ADP
bjp-15259	137	20	angiogenin	angiogenin	NOUN
bjp-15259	137	21	.	.	PUNCT
bjp-15259	138	1	in	in	ADP
bjp-15259	138	2	order	order	NOUN
bjp-15259	138	3	to	to	PART
bjp-15259	138	4	find	find	VERB
bjp-15259	138	5	out	out	ADP
bjp-15259	138	6	the	the	DET
bjp-15259	138	7	binding	bind	VERB
bjp-15259	138	8	efficiency	efficiency	NOUN
bjp-15259	138	9	of	of	ADP
bjp-15259	138	10	native	native	ADJ
bjp-15259	138	11	and	and	CCONJ
bjp-15259	138	12	mutant	mutant	ADJ
bjp-15259	138	13	angiogenin	angiogenin	NOUN
bjp-15259	138	14	with	with	ADP
bjp-15259	138	15	its	its	PRON
bjp-15259	138	16	interacting	interact	VERB
bjp-15259	138	17	partner	partner	NOUN
bjp-15259	138	18	ribonuclease	ribonuclease	NOUN
bjp-15259	138	19	inhibitor	inhibitor	NOUN
bjp-15259	138	20	,	,	PUNCT
bjp-15259	138	21	we	we	PRON
bjp-15259	138	22	implemented	implement	VERB
bjp-15259	138	23	molecular	molecular	ADJ
bjp-15259	138	24	dynamics	dynamic	NOUN
bjp-15259	138	25	approach	approach	NOUN
bjp-15259	138	26	for	for	ADP
bjp-15259	138	27	rationalizing	rationalize	VERB
bjp-15259	138	28	the	the	DET
bjp-15259	138	29	functional	functional	ADJ
bjp-15259	138	30	activity	activity	NOUN
bjp-15259	138	31	of	of	ADP
bjp-15259	138	32	these	these	DET
bjp-15259	138	33	3	3	NUM
bjp-15259	138	34	mutants	mutant	NOUN
bjp-15259	138	35	.	.	PUNCT
bjp-15259	139	1	in	in	ADP
bjp-15259	139	2	this	this	DET
bjp-15259	139	3	analysis	analysis	NOUN
bjp-15259	139	4	,	,	PUNCT
bjp-15259	139	5	we	we	PRON
bjp-15259	139	6	performed	perform	VERB
bjp-15259	139	7	3	3	NUM
bjp-15259	139	8	missense	missense	NOUN
bjp-15259	139	9	mutations	mutation	NOUN
bjp-15259	139	10	(	(	PUNCT
bjp-15259	139	11	q36l	q36l	PROPN
bjp-15259	139	12	,	,	PUNCT
bjp-15259	139	13	c63w	c63w	PROPN
bjp-15259	139	14	and	and	CCONJ
bjp-15259	139	15	h138r	h138r	PROPN
bjp-15259	139	16	)	)	PUNCT
bjp-15259	139	17	in	in	ADP
bjp-15259	139	18	the	the	DET
bjp-15259	139	19	chain	chain	NOUN
bjp-15259	139	20	a	a	PRON
bjp-15259	139	21	of	of	ADP
bjp-15259	139	22	the	the	DET
bjp-15259	139	23	pdb	pdb	PROPN
bjp-15259	139	24	ids	id	VERB
bjp-15259	139	25	2ang	2ang	PROPN
bjp-15259	139	26	and	and	CCONJ
bjp-15259	139	27	1a4y	1a4y	NUM
bjp-15259	139	28	by	by	ADP
bjp-15259	139	29	swisspdb	swisspdb	PROPN
bjp-15259	139	30	viewer	viewer	NOUN
bjp-15259	139	31	independently	independently	ADV
bjp-15259	139	32	and	and	CCONJ
bjp-15259	139	33	energy	energy	NOUN
bjp-15259	139	34	minimization	minimization	NOUN
bjp-15259	139	35	was	be	AUX
bjp-15259	139	36	performed	perform	VERB
bjp-15259	139	37	for	for	ADP
bjp-15259	139	38	the	the	DET
bjp-15259	139	39	entire	entire	ADJ
bjp-15259	139	40	complex	complex	NOUN
bjp-15259	139	41	(	(	PUNCT
bjp-15259	139	42	both	both	CCONJ
bjp-15259	139	43	native	native	ADJ
bjp-15259	139	44	and	and	CCONJ
bjp-15259	139	45	mutant	mutant	ADJ
bjp-15259	139	46	complex	complex	NOUN
bjp-15259	139	47	)	)	PUNCT
bjp-15259	139	48	by	by	ADP
bjp-15259	139	49	gromacs	gromacs	NOUN
bjp-15259	139	50	(	(	PUNCT
bjp-15259	139	51	nomad	nomad	NOUN
bjp-15259	139	52	-	-	ADJ
bjp-15259	139	53	ref	ref	NOUN
bjp-15259	139	54	)	)	PUNCT
bjp-15259	139	55	.	.	PUNCT
bjp-15259	140	1	in	in	SCONJ
bjp-15259	140	2	order	order	NOUN
bjp-15259	140	3	to	to	PART
bjp-15259	140	4	obtain	obtain	VERB
bjp-15259	140	5	the	the	DET
bjp-15259	140	6	optimized	optimize	VERB
bjp-15259	140	7	structures	structure	NOUN
bjp-15259	140	8	simulated	simulate	VERB
bjp-15259	140	9	annealing	annealing	NOUN
bjp-15259	140	10	was	be	AUX
bjp-15259	140	11	done	do	VERB
bjp-15259	140	12	using	use	VERB
bjp-15259	140	13	a	a	DET
bjp-15259	140	14	discrete	discrete	ADJ
bjp-15259	140	15	molecular	molecular	ADJ
bjp-15259	140	16	dynamics	dynamic	NOUN
bjp-15259	140	17	approach	approach	NOUN
bjp-15259	140	18	(	(	PUNCT
bjp-15259	140	19	ifold	ifold	PROPN
bjp-15259	140	20	)	)	PUNCT
bjp-15259	140	21	.	.	PUNCT
bjp-15259	141	1	we	we	PRON
bjp-15259	141	2	used	use	VERB
bjp-15259	141	3	grammx	grammx	NOUN
bjp-15259	141	4	to	to	PART
bjp-15259	141	5	dock	dock	VERB
bjp-15259	141	6	2ang	2ang	PROPN
bjp-15259	141	7	native	native	ADJ
bjp-15259	141	8	and	and	CCONJ
bjp-15259	141	9	mutant	mutant	ADJ
bjp-15259	141	10	structures	structure	NOUN
bjp-15259	141	11	with	with	ADP
bjp-15259	141	12	1a4y	1a4y	NUM
bjp-15259	141	13	and	and	CCONJ
bjp-15259	141	14	furthermore	furthermore	ADV
bjp-15259	141	15	;	;	PUNCT
bjp-15259	141	16	we	we	PRON
bjp-15259	141	17	used	use	VERB
bjp-15259	141	18	dfire	dfire	NOUN
bjp-15259	141	19	,	,	PUNCT
bjp-15259	141	20	for	for	ADP
bjp-15259	141	21	finding	find	VERB
bjp-15259	141	22	the	the	DET
bjp-15259	141	23	protein	protein	NOUN
bjp-15259	141	24	conformation	conformation	NOUN
bjp-15259	141	25	free	free	ADJ
bjp-15259	141	26	energy	energy	NOUN
bjp-15259	141	27	source	source	NOUN
bjp-15259	141	28	for	for	ADP
bjp-15259	141	29	the	the	DET
bjp-15259	141	30	docked	docked	ADJ
bjp-15259	141	31	complex	complex	NOUN
bjp-15259	141	32	retrieved	retrieve	VERB
bjp-15259	141	33	from	from	ADP
bjp-15259	141	34	grammx	grammx	NOUN
bjp-15259	141	35	.	.	PUNCT
bjp-15259	142	1	we	we	PRON
bjp-15259	142	2	used	use	VERB
bjp-15259	142	3	this	this	DET
bjp-15259	142	4	server	server	NOUN
bjp-15259	142	5	for	for	ADP
bjp-15259	142	6	the	the	DET
bjp-15259	142	7	missense	missense	NOUN
bjp-15259	142	8	mutation	mutation	NOUN
bjp-15259	142	9	analysis	analysis	NOUN
bjp-15259	142	10	with	with	ADP
bjp-15259	142	11	respect	respect	NOUN
bjp-15259	142	12	to	to	ADP
bjp-15259	142	13	finding	find	VERB
bjp-15259	142	14	the	the	DET
bjp-15259	142	15	free	free	ADJ
bjp-15259	142	16	energy	energy	NOUN
bjp-15259	142	17	source	source	NOUN
bjp-15259	142	18	of	of	ADP
bjp-15259	142	19	both	both	CCONJ
bjp-15259	142	20	native	native	ADJ
bjp-15259	142	21	and	and	CCONJ
bjp-15259	142	22	mutants	mutant	NOUN
bjp-15259	142	23	of	of	ADP
bjp-15259	142	24	angiogenin	angiogenin	NOUN
bjp-15259	142	25	with	with	ADP
bjp-15259	142	26	ribonuclease	ribonuclease	NOUN
bjp-15259	142	27	inhibitor	inhibitor	NOUN
bjp-15259	142	28	.	.	PUNCT
bjp-15259	143	1	in	in	ADP
bjp-15259	143	2	this	this	DET
bjp-15259	143	3	analysis	analysis	NOUN
bjp-15259	143	4	,	,	PUNCT
bjp-15259	143	5	we	we	PRON
bjp-15259	143	6	found	find	VERB
bjp-15259	143	7	that	that	SCONJ
bjp-15259	143	8	the	the	DET
bjp-15259	143	9	binding	bind	VERB
bjp-15259	143	10	free	free	ADJ
bjp-15259	143	11	energy	energy	NOUN
bjp-15259	143	12	for	for	ADP
bjp-15259	143	13	ribonuclease	ribonuclease	NOUN
bjp-15259	143	14	inhibitor	inhibitor	NOUN
bjp-15259	143	15	with	with	ADP
bjp-15259	143	16	native	native	ADJ
bjp-15259	143	17	angiogenin	angiogenin	NOUN
bjp-15259	143	18	protein	protein	NOUN
bjp-15259	143	19	was	be	AUX
bjp-15259	143	20	found	find	VERB
bjp-15259	143	21	to	to	PART
bjp-15259	143	22	be	be	AUX
bjp-15259	143	23	-1215.6	-1215.6	X
bjp-15259	143	24	kcal	kcal	ADJ
bjp-15259	143	25	/	/	SYM
bjp-15259	143	26	mol	mol	PROPN
bjp-15259	143	27	,	,	PUNCT
bjp-15259	143	28	which	which	PRON
bjp-15259	143	29	had	have	VERB
bjp-15259	143	30	a	a	DET
bjp-15259	143	31	higher	high	ADJ
bjp-15259	143	32	binding	bind	VERB
bjp-15259	143	33	affinity	affinity	NOUN
bjp-15259	143	34	compared	compare	VERB
bjp-15259	143	35	to	to	ADP
bjp-15259	143	36	the	the	DET
bjp-15259	143	37	mutants	mutant	NOUN
bjp-15259	143	38	.	.	PUNCT
bjp-15259	144	1	this	this	DET
bjp-15259	144	2	analysis	analysis	NOUN
bjp-15259	144	3	portrayed	portray	VERB
bjp-15259	144	4	that	that	SCONJ
bjp-15259	144	5	native	native	ADJ
bjp-15259	144	6	angiogenin	angiogenin	NOUN
bjp-15259	144	7	exhibited	exhibit	VERB
bjp-15259	144	8	higher	high	ADJ
bjp-15259	144	9	binding	bind	VERB
bjp-15259	144	10	affinity	affinity	NOUN
bjp-15259	144	11	with	with	ADP
bjp-15259	144	12	ribonuclease	ribonuclease	NOUN
bjp-15259	144	13	inhibitor	inhibitor	NOUN
bjp-15259	144	14	.	.	PUNCT
bjp-15259	145	1	hence	hence	ADV
bjp-15259	145	2	,	,	PUNCT
bjp-15259	145	3	the	the	DET
bjp-15259	145	4	lesser	lesser	ADV
bjp-15259	145	5	binding	bind	VERB
bjp-15259	145	6	free	free	ADJ
bjp-15259	145	7	energies	energy	NOUN
bjp-15259	145	8	may	may	AUX
bjp-15259	145	9	probably	probably	ADV
bjp-15259	145	10	be	be	AUX
bjp-15259	145	11	due	due	ADJ
bjp-15259	145	12	to	to	ADP
bjp-15259	145	13	loss	loss	NOUN
bjp-15259	145	14	of	of	ADP
bjp-15259	145	15	intermolecular	intermolecular	ADJ
bjp-15259	145	16	non	non	ADJ
bjp-15259	145	17	-	-	ADJ
bjp-15259	145	18	covalent	covalent	ADJ
bjp-15259	145	19	interactions	interaction	NOUN
bjp-15259	145	20	.	.	PUNCT
bjp-15259	146	1	this	this	DET
bjp-15259	146	2	analysis	analysis	NOUN
bjp-15259	146	3	clearly	clearly	ADV
bjp-15259	146	4	portrayed	portray	VERB
bjp-15259	146	5	that	that	SCONJ
bjp-15259	146	6	the	the	DET
bjp-15259	146	7	native	native	ADJ
bjp-15259	146	8	complex	complex	NOUN
bjp-15259	146	9	had	have	VERB
bjp-15259	146	10	high	high	ADJ
bjp-15259	146	11	intermolecular	intermolecular	ADJ
bjp-15259	146	12	non	non	ADJ
bjp-15259	146	13	covalent	covalent	NOUN
bjp-15259	146	14	interactions	interaction	NOUN
bjp-15259	146	15	than	than	ADP
bjp-15259	146	16	mutant	mutant	ADJ
bjp-15259	146	17	complexes	complex	NOUN
bjp-15259	146	18	.	.	PUNCT
bjp-15259	147	1	figure	figure	NOUN
bjp-15259	147	2	3	3	NUM
bjp-15259	147	3	showed	show	VERB
bjp-15259	147	4	the	the	DET
bjp-15259	147	5	docked	docked	ADJ
bjp-15259	147	6	complex	complex	NOUN
bjp-15259	147	7	of	of	ADP
bjp-15259	147	8	ribonuclease	ribonuclease	NOUN
bjp-15259	147	9	inhibitor	inhibitor	NOUN
bjp-15259	147	10	with	with	ADP
bjp-15259	147	11	(	(	PUNCT
bjp-15259	147	12	a	a	X
bjp-15259	147	13	)	)	PUNCT
bjp-15259	147	14	native	native	ADJ
bjp-15259	147	15	angiogenin	angiogenin	NOUN
bjp-15259	147	16	(	(	PUNCT
bjp-15259	147	17	b	b	NOUN
bjp-15259	147	18	)	)	PUNCT
bjp-15259	147	19	q36l	q36l	PROPN
bjp-15259	147	20	,	,	PUNCT
bjp-15259	147	21	(	(	PUNCT
bjp-15259	147	22	c	c	X
bjp-15259	147	23	)	)	PUNCT
bjp-15259	147	24	c63w	c63w	PROPN
bjp-15259	147	25	and	and	CCONJ
bjp-15259	147	26	(	(	PUNCT
bjp-15259	147	27	d	d	NOUN
bjp-15259	147	28	)	)	PUNCT
bjp-15259	147	29	h138r	h138r	PROPN
bjp-15259	147	30	.	.	PUNCT
bjp-15259	148	1	to	to	PART
bjp-15259	148	2	understand	understand	VERB
bjp-15259	148	3	the	the	DET
bjp-15259	148	4	cause	cause	NOUN
bjp-15259	148	5	of	of	ADP
bjp-15259	148	6	the	the	DET
bjp-15259	148	7	lower	low	ADJ
bjp-15259	148	8	substrate	substrate	NOUN
bjp-15259	148	9	binding	bind	VERB
bjp-15259	148	10	efficiency	efficiency	NOUN
bjp-15259	148	11	of	of	ADP
bjp-15259	148	12	the	the	DET
bjp-15259	148	13	3	3	NUM
bjp-15259	148	14	detrimental	detrimental	ADJ
bjp-15259	148	15	missense	missense	NOUN
bjp-15259	148	16	mutation	mutation	NOUN
bjp-15259	148	17	,	,	PUNCT
bjp-15259	148	18	the	the	DET
bjp-15259	148	19	program	program	NOUN
bjp-15259	148	20	elnemo	elnemo	NOUN
bjp-15259	148	21	was	be	AUX
bjp-15259	148	22	used	use	VERB
bjp-15259	148	23	for	for	ADP
bjp-15259	148	24	comparing	compare	VERB
bjp-15259	148	25	the	the	DET
bjp-15259	148	26	amino	amino	ADJ
bjp-15259	148	27	acids	acid	NOUN
bjp-15259	148	28	flexibility	flexibility	NOUN
bjp-15259	148	29	that	that	PRON
bjp-15259	148	30	was	be	AUX
bjp-15259	148	31	involved	involve	VERB
bjp-15259	148	32	in	in	ADP
bjp-15259	148	33	binding	bind	VERB
bjp-15259	148	34	with	with	ADP
bjp-15259	148	35	ribonuclease	ribonuclease	NOUN
bjp-15259	148	36	inhibitor	inhibitor	NOUN
bjp-15259	148	37	of	of	ADP
bjp-15259	148	38	both	both	CCONJ
bjp-15259	148	39	the	the	DET
bjp-15259	148	40	native	native	ADJ
bjp-15259	148	41	protein	protein	NOUN
bjp-15259	148	42	and	and	CCONJ
bjp-15259	148	43	the	the	DET
bjp-15259	148	44	mutants	mutant	NOUN
bjp-15259	148	45	.	.	PUNCT
bjp-15259	149	1	table	table	NOUN
bjp-15259	149	2	iii	iii	PROPN
bjp-15259	150	1	and	and	CCONJ
bjp-15259	150	2	depicted	depict	VERB
bjp-15259	150	3	the	the	DET
bjp-15259	150	4	amino	amino	NOUN
bjp-15259	150	5	acids	acid	NOUN
bjp-15259	150	6	flexibility	flexibility	NOUN
bjp-15259	150	7	in	in	ADP
bjp-15259	150	8	the	the	DET
bjp-15259	150	9	substrate	substrate	NOUN
bjp-15259	150	10	binding	bind	VERB
bjp-15259	150	11	pocket	pocket	NOUN
bjp-15259	150	12	(	(	PUNCT
bjp-15259	150	13	active	active	ADJ
bjp-15259	150	14	site	site	NOUN
bjp-15259	150	15	)	)	PUNCT
bjp-15259	150	16	of	of	ADP
bjp-15259	150	17	both	both	CCONJ
bjp-15259	150	18	the	the	DET
bjp-15259	150	19	native	native	ADJ
bjp-15259	150	20	and	and	CCONJ
bjp-15259	150	21	mutant	mutant	ADJ
bjp-15259	150	22	proteins	protein	NOUN
bjp-15259	150	23	through	through	ADP
bjp-15259	150	24	the	the	DET
bjp-15259	150	25	normalized	normalize	VERB
bjp-15259	150	26	mean	mean	ADJ
bjp-15259	150	27	square	square	ADJ
bjp-15259	150	28	displacement	displacement	NOUN
bjp-15259	150	29	<	<	X
bjp-15259	150	30	r2	r2	PROPN
bjp-15259	150	31	>	>	PUNCT
bjp-15259	150	32	.	.	PUNCT
bjp-15259	151	1	these	these	DET
bjp-15259	151	2	data	datum	NOUN
bjp-15259	151	3	were	be	AUX
bjp-15259	151	4	further	far	ADV
bjp-15259	151	5	categorized	categorize	VERB
bjp-15259	151	6	into	into	ADP
bjp-15259	151	7	three	three	NUM
bjp-15259	151	8	terms	term	NOUN
bjp-15259	151	9	of	of	ADP
bjp-15259	151	10	flexibility	flexibility	NOUN
bjp-15259	151	11	.	.	PUNCT
bjp-15259	152	1	the	the	DET
bjp-15259	152	2	first	first	ADJ
bjp-15259	152	3	category	category	NOUN
bjp-15259	152	4	was	be	AUX
bjp-15259	152	5	where	where	SCONJ
bjp-15259	152	6	the	the	DET
bjp-15259	152	7	<	<	X
bjp-15259	152	8	r2	r2	PROPN
bjp-15259	152	9	>	>	X
bjp-15259	152	10	of	of	ADP
bjp-15259	152	11	the	the	DET
bjp-15259	152	12	amino	amino	NOUN
bjp-15259	152	13	acids	acid	NOUN
bjp-15259	152	14	in	in	ADP
bjp-15259	152	15	the	the	DET
bjp-15259	152	16	substrate	substrate	NOUN
bjp-15259	152	17	binding	bind	VERB
bjp-15259	152	18	pocket	pocket	NOUN
bjp-15259	152	19	of	of	ADP
bjp-15259	152	20	the	the	DET
bjp-15259	152	21	mutant	mutant	NOUN
bjp-15259	152	22	was	be	AUX
bjp-15259	152	23	the	the	DET
bjp-15259	152	24	same	same	ADJ
bjp-15259	152	25	as	as	ADP
bjp-15259	152	26	that	that	PRON
bjp-15259	152	27	of	of	ADP
bjp-15259	152	28	the	the	DET
bjp-15259	152	29	native	native	ADJ
bjp-15259	152	30	protein	protein	NOUN
bjp-15259	152	31	(	(	PUNCT
bjp-15259	152	32	termed	term	VERB
bjp-15259	152	33	identical	identical	ADJ
bjp-15259	152	34	flexibility	flexibility	NOUN
bjp-15259	152	35	)	)	PUNCT
bjp-15259	152	36	.	.	PUNCT
bjp-15259	153	1	the	the	DET
bjp-15259	153	2	second	second	ADJ
bjp-15259	153	3	category	category	NOUN
bjp-15259	153	4	was	be	AUX
bjp-15259	153	5	where	where	SCONJ
bjp-15259	153	6	the	the	DET
bjp-15259	153	7	<	<	X
bjp-15259	153	8	r2	r2	PROPN
bjp-15259	153	9	>	>	X
bjp-15259	153	10	of	of	ADP
bjp-15259	153	11	the	the	DET
bjp-15259	153	12	amino	amino	NOUN
bjp-15259	153	13	acids	acid	NOUN
bjp-15259	153	14	in	in	ADP
bjp-15259	153	15	the	the	DET
bjp-15259	153	16	substrate	substrate	NOUN
bjp-15259	153	17	binding	bind	VERB
bjp-15259	153	18	pocket	pocket	NOUN
bjp-15259	153	19	of	of	ADP
bjp-15259	153	20	the	the	DET
bjp-15259	153	21	mutant	mutant	NOUN
bjp-15259	153	22	was	be	AUX
bjp-15259	153	23	higher	high	ADJ
bjp-15259	153	24	than	than	ADP
bjp-15259	153	25	that	that	PRON
bjp-15259	153	26	of	of	ADP
bjp-15259	153	27	the	the	DET
bjp-15259	153	28	native	native	ADJ
bjp-15259	153	29	protein	protein	NOUN
bjp-15259	153	30	(	(	PUNCT
bjp-15259	153	31	termed	term	VERB
bjp-15259	153	32	increased	increase	VERB
bjp-15259	153	33	flexibility	flexibility	NOUN
bjp-15259	153	34	)	)	PUNCT
bjp-15259	153	35	.	.	PUNCT
bjp-15259	154	1	the	the	DET
bjp-15259	154	2	last	last	ADJ
bjp-15259	154	3	category	category	NOUN
bjp-15259	154	4	was	be	AUX
bjp-15259	154	5	where	where	SCONJ
bjp-15259	154	6	the	the	DET
bjp-15259	154	7	<	<	X
bjp-15259	154	8	r2	r2	PROPN
bjp-15259	154	9	>	>	X
bjp-15259	154	10	of	of	ADP
bjp-15259	154	11	the	the	DET
bjp-15259	154	12	amino	amino	NOUN
bjp-15259	154	13	acids	acid	NOUN
bjp-15259	154	14	in	in	ADP
bjp-15259	154	15	the	the	DET
bjp-15259	154	16	substrate	substrate	NOUN
bjp-15259	154	17	binding	bind	VERB
bjp-15259	154	18	pocket	pocket	NOUN
bjp-15259	154	19	of	of	ADP
bjp-15259	154	20	a	a	DET
bjp-15259	154	21	mutant	mutant	NOUN
bjp-15259	154	22	was	be	AUX
bjp-15259	154	23	lower	low	ADJ
bjp-15259	154	24	than	than	ADP
bjp-15259	154	25	that	that	PRON
bjp-15259	154	26	of	of	ADP
bjp-15259	154	27	the	the	DET
bjp-15259	154	28	native	native	ADJ
bjp-15259	154	29	protein	protein	NOUN
bjp-15259	154	30	(	(	PUNCT
bjp-15259	154	31	termed	term	VERB
bjp-15259	154	32	decreased	decrease	VERB
bjp-15259	154	33	flexibility	flexibility	NOUN
bjp-15259	154	34	)	)	PUNCT
bjp-15259	154	35	.	.	PUNCT
bjp-15259	155	1	from	from	ADP
bjp-15259	155	2	the	the	DET
bjp-15259	155	3	above	above	ADJ
bjp-15259	155	4	investigation	investigation	NOUN
bjp-15259	155	5	,	,	PUNCT
bjp-15259	155	6	we	we	PRON
bjp-15259	155	7	observed	observe	VERB
bjp-15259	155	8	the	the	DET
bjp-15259	155	9	increased	increase	VERB
bjp-15259	155	10	flexibility	flexibility	NOUN
bjp-15259	155	11	of	of	ADP
bjp-15259	155	12	the	the	DET
bjp-15259	155	13	substrate	substrate	NOUN
bjp-15259	155	14	binding	bind	VERB
bjp-15259	155	15	amino	amino	ADJ
bjp-15259	155	16	acids	acid	NOUN
bjp-15259	155	17	of	of	ADP
bjp-15259	155	18	these	these	DET
bjp-15259	155	19	3	3	NUM
bjp-15259	155	20	mutants	mutant	NOUN
bjp-15259	155	21	(	(	PUNCT
bjp-15259	155	22	table	table	NOUN
bjp-15259	155	23	iii	iii	NOUN
bjp-15259	155	24	)	)	PUNCT
bjp-15259	155	25	.	.	PUNCT
bjp-15259	156	1	figure	figure	NOUN
bjp-15259	156	2	4	4	NUM
bjp-15259	156	3	showed	show	VERB
bjp-15259	156	4	the	the	DET
bjp-15259	156	5	fluctuation	fluctuation	NOUN
bjp-15259	156	6	of	of	ADP
bjp-15259	156	7	flexibility	flexibility	NOUN
bjp-15259	156	8	in	in	ADP
bjp-15259	156	9	both	both	CCONJ
bjp-15259	156	10	the	the	DET
bjp-15259	156	11	native	native	ADJ
bjp-15259	156	12	and	and	CCONJ
bjp-15259	156	13	mutant	mutant	ADJ
bjp-15259	156	14	structures	structure	NOUN
bjp-15259	156	15	.	.	PUNCT
bjp-15259	157	1	thus	thus	ADV
bjp-15259	157	2	,	,	PUNCT
bjp-15259	157	3	most	most	ADJ
bjp-15259	157	4	of	of	ADP
bjp-15259	157	5	the	the	DET
bjp-15259	157	6	amino	amino	NOUN
bjp-15259	157	7	acids	acid	NOUN
bjp-15259	157	8	lost	lose	VERB
bjp-15259	157	9	their	their	PRON
bjp-15259	157	10	flexibility	flexibility	NOUN
bjp-15259	157	11	during	during	ADP
bjp-15259	157	12	substrate	substrate	NOUN
bjp-15259	157	13	binding	binding	NOUN
bjp-15259	157	14	of	of	ADP
bjp-15259	157	15	these	these	DET
bjp-15259	157	16	mutants	mutant	NOUN
bjp-15259	157	17	and	and	CCONJ
bjp-15259	157	18	thus	thus	ADV
bjp-15259	157	19	they	they	PRON
bjp-15259	157	20	lost	lose	VERB
bjp-15259	157	21	their	their	PRON
bjp-15259	157	22	binding	bind	VERB
bjp-15259	157	23	efficiency	efficiency	NOUN
bjp-15259	157	24	with	with	ADP
bjp-15259	157	25	the	the	DET
bjp-15259	157	26	substrate	substrate	NOUN
bjp-15259	157	27	.	.	PUNCT
bjp-15259	158	1	thus	thus	ADV
bjp-15259	158	2	,	,	PUNCT
bjp-15259	158	3	this	this	DET
bjp-15259	158	4	study	study	NOUN
bjp-15259	158	5	showed	show	VERB
bjp-15259	158	6	that	that	SCONJ
bjp-15259	158	7	,	,	PUNCT
bjp-15259	158	8	increased	increase	VERB
bjp-15259	158	9	bangladesh	bangladesh	PROPN
bjp-15259	158	10	j	j	PROPN
bjp-15259	158	11	pharmacol	pharmacol	PROPN
bjp-15259	158	12	2013	2013	NUM
bjp-15259	158	13	;	;	PUNCT
bjp-15259	158	14	8	8	NUM
bjp-15259	158	15	:	:	PUNCT
bjp-15259	158	16	382	382	NUM
bjp-15259	158	17	-	-	SYM
bjp-15259	158	18	389	389	NUM
bjp-15259	158	19	387	387	NUM
bjp-15259	158	20	a	a	DET
bjp-15259	158	21	b	b	NOUN
bjp-15259	158	22	c	c	NOUN
bjp-15259	158	23	d	d	NOUN
bjp-15259	158	24	figure	figure	NOUN
bjp-15259	158	25	3	3	NUM
bjp-15259	158	26	:	:	PUNCT
bjp-15259	158	27	docked	docked	ADJ
bjp-15259	158	28	complexes	complex	NOUN
bjp-15259	158	29	of	of	ADP
bjp-15259	158	30	native	native	ADJ
bjp-15259	158	31	and	and	CCONJ
bjp-15259	158	32	mutant	mutant	ADJ
bjp-15259	158	33	angiogenin	angiogenin	NOUN
bjp-15259	158	34	with	with	ADP
bjp-15259	158	35	ribonuclease	ribonuclease	NOUN
bjp-15259	158	36	inhibitor	inhibitor	NOUN
bjp-15259	158	37	(	(	PUNCT
bjp-15259	158	38	a	a	NOUN
bjp-15259	158	39	)	)	PUNCT
bjp-15259	158	40	docked	docked	ADJ
bjp-15259	158	41	complex	complex	NOUN
bjp-15259	158	42	of	of	ADP
bjp-15259	158	43	native	native	ADJ
bjp-15259	158	44	angiogenin	angiogenin	NOUN
bjp-15259	158	45	(	(	PUNCT
bjp-15259	158	46	green	green	ADJ
bjp-15259	158	47	)	)	PUNCT
bjp-15259	158	48	and	and	CCONJ
bjp-15259	158	49	ribonuclease	ribonuclease	NOUN
bjp-15259	158	50	inhibitor	inhibitor	NOUN
bjp-15259	158	51	(	(	PUNCT
bjp-15259	158	52	grey	grey	PROPN
bjp-15259	158	53	)	)	PUNCT
bjp-15259	158	54	having	have	VERB
bjp-15259	158	55	the	the	DET
bjp-15259	158	56	free	free	ADJ
bjp-15259	158	57	energy	energy	NOUN
bjp-15259	158	58	of	of	ADP
bjp-15259	158	59	-1215.59	-1215.59	PROPN
bjp-15259	158	60	,	,	PUNCT
bjp-15259	158	61	(	(	PUNCT
bjp-15259	158	62	b	b	NOUN
bjp-15259	158	63	)	)	PUNCT
bjp-15259	158	64	docked	docked	ADJ
bjp-15259	158	65	complex	complex	NOUN
bjp-15259	158	66	of	of	ADP
bjp-15259	158	67	q36l	q36l	PROPN
bjp-15259	158	68	(	(	PUNCT
bjp-15259	158	69	red	red	ADJ
bjp-15259	158	70	)	)	PUNCT
bjp-15259	158	71	and	and	CCONJ
bjp-15259	158	72	ribonuclease	ribonuclease	NOUN
bjp-15259	158	73	inhibitor	inhibitor	NOUN
bjp-15259	158	74	(	(	PUNCT
bjp-15259	158	75	grey	grey	PROPN
bjp-15259	158	76	)	)	PUNCT
bjp-15259	158	77	having	have	VERB
bjp-15259	158	78	the	the	DET
bjp-15259	158	79	free	free	ADJ
bjp-15259	158	80	energy	energy	NOUN
bjp-15259	158	81	of	of	ADP
bjp-15259	158	82	-1203.83	-1203.83	PROPN
bjp-15259	158	83	,	,	PUNCT
bjp-15259	158	84	(	(	PUNCT
bjp-15259	158	85	c	c	NOUN
bjp-15259	158	86	)	)	PUNCT
bjp-15259	158	87	docked	docked	ADJ
bjp-15259	158	88	complex	complex	NOUN
bjp-15259	158	89	of	of	ADP
bjp-15259	158	90	c63w	c63w	PROPN
bjp-15259	158	91	(	(	PUNCT
bjp-15259	158	92	blue	blue	ADJ
bjp-15259	158	93	)	)	PUNCT
bjp-15259	158	94	and	and	CCONJ
bjp-15259	158	95	ribonuclease	ribonuclease	NOUN
bjp-15259	158	96	inhibitor	inhibitor	NOUN
bjp-15259	158	97	(	(	PUNCT
bjp-15259	158	98	grey	grey	PROPN
bjp-15259	158	99	)	)	PUNCT
bjp-15259	158	100	having	have	VERB
bjp-15259	158	101	the	the	DET
bjp-15259	158	102	free	free	ADJ
bjp-15259	158	103	energy	energy	NOUN
bjp-15259	158	104	of	of	ADP
bjp-15259	158	105	-1202.48	-1202.48	PROPN
bjp-15259	158	106	,	,	PUNCT
bjp-15259	158	107	(	(	PUNCT
bjp-15259	158	108	d	d	X
bjp-15259	158	109	)	)	PUNCT
bjp-15259	158	110	docked	docked	ADJ
bjp-15259	158	111	complex	complex	NOUN
bjp-15259	158	112	of	of	ADP
bjp-15259	158	113	h138r	h138r	PROPN
bjp-15259	158	114	(	(	PUNCT
bjp-15259	158	115	magenta	magenta	NOUN
bjp-15259	158	116	)	)	PUNCT
bjp-15259	158	117	and	and	CCONJ
bjp-15259	158	118	ribonuclease	ribonuclease	NOUN
bjp-15259	158	119	inhibitor	inhibitor	NOUN
bjp-15259	158	120	(	(	PUNCT
bjp-15259	158	121	grey	grey	PROPN
bjp-15259	158	122	)	)	PUNCT
bjp-15259	158	123	having	have	VERB
bjp-15259	158	124	the	the	DET
bjp-15259	158	125	free	free	ADJ
bjp-15259	158	126	energy	energy	NOUN
bjp-15259	158	127	of	of	ADP
bjp-15259	158	128	1198.17	1198.17	NUM
bjp-15259	158	129	table	table	NOUN
bjp-15259	158	130	iii	iii	NOUN
bjp-15259	158	131	substrate	substrate	NOUN
bjp-15259	158	132	binding	bind	VERB
bjp-15259	158	133	amino	amino	ADJ
bjp-15259	158	134	acids	acid	NOUN
bjp-15259	158	135	of	of	ADP
bjp-15259	158	136	mutants	mutant	NOUN
bjp-15259	158	137	with	with	ADP
bjp-15259	158	138	different	different	ADJ
bjp-15259	158	139	ranges	range	NOUN
bjp-15259	158	140	of	of	ADP
bjp-15259	158	141	flexibility	flexibility	NOUN
bjp-15259	158	142	based	base	VERB
bjp-15259	158	143	on	on	ADP
bjp-15259	158	144	<	<	X
bjp-15259	158	145	r2	r2	PROPN
bjp-15259	158	146	>	>	X
bjp-15259	158	147	variant	variant	NOUN
bjp-15259	158	148	a	a	DET
bjp-15259	158	149	b	b	NOUN
bjp-15259	158	150	c	c	NOUN
bjp-15259	158	151	<	<	X
bjp-15259	158	152	r2	r2	X
bjp-15259	158	153	>	>	X
bjp-15259	158	154	<	<	X
bjp-15259	158	155	r2	r2	PROPN
bjp-15259	158	156	>	>	X
bjp-15259	158	157	<	<	X
bjp-15259	158	158	r2	r2	PROPN
bjp-15259	158	159	>	>	X
bjp-15259	158	160	<	<	X
bjp-15259	158	161	r2	r2	PROPN
bjp-15259	158	162	>	>	X
bjp-15259	158	163	q36l	q36l	PROPN
bjp-15259	158	164	8	8	NUM
bjp-15259	158	165	12	12	NUM
bjp-15259	158	166	0	0	NUM
bjp-15259	158	167	c63w	c63w	NOUN
bjp-15259	158	168	8	8	NUM
bjp-15259	158	169	12	12	NUM
bjp-15259	158	170	0	0	NUM
bjp-15259	158	171	h138r	h138r	PROPN
bjp-15259	158	172	7	7	NUM
bjp-15259	158	173	13	13	NUM
bjp-15259	158	174	0	0	NUM
bjp-15259	158	175	where	where	SCONJ
bjp-15259	158	176	the	the	DET
bjp-15259	158	177	letter	letter	NOUN
bjp-15259	158	178	‘	'	PUNCT
bjp-15259	158	179	a	a	DET
bjp-15259	158	180	’	'	PUNCT
bjp-15259	158	181	denotes	denote	NOUN
bjp-15259	158	182	amino	amino	ADJ
bjp-15259	158	183	acids	acid	NOUN
bjp-15259	158	184	with	with	ADP
bjp-15259	158	185	decreased	decrease	VERB
bjp-15259	158	186	flexibility	flexibility	NOUN
bjp-15259	158	187	of	of	ADP
bjp-15259	158	188	mutants	mutant	NOUN
bjp-15259	158	189	than	than	ADP
bjp-15259	158	190	native	native	ADJ
bjp-15259	158	191	;	;	PUNCT
bjp-15259	158	192	‘	'	PUNCT
bjp-15259	158	193	b	b	X
bjp-15259	158	194	’	'	PUNCT
bjp-15259	158	195	denotes	denote	NOUN
bjp-15259	158	196	amino	amino	ADJ
bjp-15259	158	197	acids	acid	NOUN
bjp-15259	158	198	with	with	ADP
bjp-15259	158	199	increased	increase	VERB
bjp-15259	158	200	flexibility	flexibility	NOUN
bjp-15259	158	201	of	of	ADP
bjp-15259	158	202	both	both	CCONJ
bjp-15259	158	203	native	native	ADJ
bjp-15259	158	204	and	and	CCONJ
bjp-15259	158	205	mutants	mutant	NOUN
bjp-15259	158	206	;	;	PUNCT
bjp-15259	158	207	‘	'	PUNCT
bjp-15259	158	208	c	c	X
bjp-15259	158	209	’	'	PUNCT
bjp-15259	158	210	denotes	denote	NOUN
bjp-15259	158	211	amino	amino	ADJ
bjp-15259	158	212	acids	acid	NOUN
bjp-15259	158	213	with	with	ADP
bjp-15259	158	214	identical	identical	ADJ
bjp-15259	158	215	flexibility	flexibility	NOUN
bjp-15259	158	216	of	of	ADP
bjp-15259	158	217	both	both	CCONJ
bjp-15259	158	218	native	native	ADJ
bjp-15259	158	219	and	and	CCONJ
bjp-15259	158	220	mutants	mutant	NOUN
bjp-15259	158	221	flexibility	flexibility	NOUN
bjp-15259	158	222	of	of	ADP
bjp-15259	158	223	the	the	DET
bjp-15259	158	224	protein	protein	NOUN
bjp-15259	158	225	was	be	AUX
bjp-15259	158	226	the	the	DET
bjp-15259	158	227	cause	cause	NOUN
bjp-15259	158	228	for	for	ADP
bjp-15259	158	229	the	the	DET
bjp-15259	158	230	loss	loss	NOUN
bjp-15259	158	231	in	in	ADP
bjp-15259	158	232	substrate	substrate	NOUN
bjp-15259	158	233	binding	bind	VERB
bjp-15259	158	234	affinity	affinity	NOUN
bjp-15259	158	235	.	.	PUNCT
bjp-15259	159	1	conclusion	conclusion	NOUN
bjp-15259	159	2	by	by	ADP
bjp-15259	159	3	sequence	sequence	NOUN
bjp-15259	159	4	and	and	CCONJ
bjp-15259	159	5	structure	structure	NOUN
bjp-15259	159	6	based	base	VERB
bjp-15259	159	7	approaches	approach	NOUN
bjp-15259	159	8	,	,	PUNCT
bjp-15259	159	9	we	we	PRON
bjp-15259	159	10	identified	identify	VERB
bjp-15259	159	11	three	three	NUM
bjp-15259	159	12	variants	variant	NOUN
bjp-15259	159	13	(	(	PUNCT
bjp-15259	159	14	q36l	q36l	PROPN
bjp-15259	159	15	,	,	PUNCT
bjp-15259	159	16	c63w	c63w	PROPN
bjp-15259	159	17	and	and	CCONJ
bjp-15259	159	18	h138r	h138r	PROPN
bjp-15259	159	19	)	)	PUNCT
bjp-15259	159	20	were	be	AUX
bjp-15259	159	21	considered	consider	VERB
bjp-15259	159	22	to	to	PART
bjp-15259	159	23	be	be	AUX
bjp-15259	159	24	most	most	ADV
bjp-15259	159	25	detrimental	detrimental	ADJ
bjp-15259	159	26	point	point	NOUN
bjp-15259	159	27	mutations	mutation	NOUN
bjp-15259	159	28	causing	cause	VERB
bjp-15259	159	29	amyotrophic	amyotrophic	ADJ
bjp-15259	159	30	lateral	lateral	ADJ
bjp-15259	159	31	sclerosis	sclerosis	NOUN
bjp-15259	159	32	.	.	PUNCT
bjp-15259	160	1	references	reference	NOUN
bjp-15259	160	2	baker	baker	PROPN
bjp-15259	160	3	m	m	PROPN
bjp-15259	160	4	,	,	PUNCT
bjp-15259	160	5	mackenzie	mackenzie	PROPN
bjp-15259	160	6	ir	ir	PROPN
bjp-15259	160	7	,	,	PUNCT
bjp-15259	160	8	pickering	pickere	VERB
bjp-15259	160	9	-	-	PUNCT
bjp-15259	160	10	brown	brown	ADJ
bjp-15259	160	11	sm	sm	PROPN
bjp-15259	160	12	,	,	PUNCT
bjp-15259	160	13	gass	gass	PROPN
bjp-15259	160	14	j	j	PROPN
bjp-15259	160	15	,	,	PUNCT
bjp-15259	160	16	rademakers	rademaker	NOUN
bjp-15259	160	17	r.	r.	NOUN
bjp-15259	160	18	mutations	mutation	NOUN
bjp-15259	160	19	in	in	ADP
bjp-15259	160	20	progranulin	progranulin	ADJ
bjp-15259	160	21	cause	cause	VERB
bjp-15259	160	22	tau	tau	NOUN
bjp-15259	160	23	-	-	PUNCT
bjp-15259	160	24	negative	negative	ADJ
bjp-15259	160	25	frontotemporal	frontotemporal	ADJ
bjp-15259	160	26	dementia	dementia	NOUN
bjp-15259	160	27	linked	link	VERB
bjp-15259	160	28	to	to	PART
bjp-15259	160	29	chromosome	chromosome	VERB
bjp-15259	160	30	17	17	NUM
bjp-15259	160	31	.	.	PUNCT
bjp-15259	161	1	nature	nature	NOUN
bjp-15259	161	2	2006	2006	NUM
bjp-15259	161	3	;	;	PUNCT
bjp-15259	161	4	442	442	NUM
bjp-15259	161	5	:	:	PUNCT
bjp-15259	161	6	916	916	NUM
bjp-15259	161	7	-	-	SYM
bjp-15259	161	8	19	19	NUM
bjp-15259	161	9	.	.	PUNCT
bjp-15259	161	10	bava	bava	PROPN
bjp-15259	161	11	ka	ka	PROPN
bjp-15259	161	12	,	,	PUNCT
bjp-15259	161	13	gromiha	gromiha	VERB
bjp-15259	161	14	mm	mm	PROPN
bjp-15259	161	15	,	,	PUNCT
bjp-15259	161	16	uedaira	uedaira	PROPN
bjp-15259	161	17	h	h	PROPN
bjp-15259	161	18	,	,	PUNCT
bjp-15259	161	19	kitajima	kitajima	PROPN
bjp-15259	161	20	k	k	PROPN
bjp-15259	161	21	,	,	PUNCT
bjp-15259	161	22	sarai	sarai	ADJ
bjp-15259	161	23	a.	a.	NOUN
bjp-15259	161	24	protherm	protherm	PROPN
bjp-15259	161	25	,	,	PUNCT
bjp-15259	161	26	version	version	NOUN
bjp-15259	161	27	4.0	4.0	NUM
bjp-15259	161	28	:	:	PUNCT
bjp-15259	161	29	thermodynamic	thermodynamic	ADJ
bjp-15259	161	30	database	database	NOUN
bjp-15259	161	31	for	for	ADP
bjp-15259	161	32	proteins	protein	NOUN
bjp-15259	161	33	and	and	CCONJ
bjp-15259	161	34	mutants	mutant	NOUN
bjp-15259	161	35	.	.	PUNCT
bjp-15259	162	1	nucleic	nucleic	ADJ
bjp-15259	162	2	acids	acid	NOUN
bjp-15259	162	3	res	re	NOUN
bjp-15259	162	4	.	.	PUNCT
bjp-15259	162	5	2004	2004	NUM
bjp-15259	162	6	;	;	PUNCT
bjp-15259	162	7	32	32	NUM
bjp-15259	162	8	:	:	SYM
bjp-15259	162	9	120	120	NUM
bjp-15259	162	10	-	-	SYM
bjp-15259	162	11	21	21	NUM
bjp-15259	162	12	.	.	PUNCT
bjp-15259	162	13	bento	bento	NOUN
bjp-15259	162	14	-	-	PUNCT
bjp-15259	162	15	abreu	abreu	PROPN
bjp-15259	162	16	a	a	PROPN
bjp-15259	162	17	,	,	PUNCT
bjp-15259	162	18	van	van	PROPN
bjp-15259	162	19	damme	damme	PROPN
bjp-15259	162	20	p	p	PROPN
bjp-15259	162	21	,	,	PUNCT
bjp-15259	162	22	van	van	PROPN
bjp-15259	162	23	den	den	PROPN
bjp-15259	162	24	bosch	bosch	PROPN
bjp-15259	162	25	l	l	PROPN
bjp-15259	162	26	,	,	PUNCT
bjp-15259	162	27	robberecht	robberecht	VERB
bjp-15259	162	28	w.	w.	NOUN
bjp-15259	162	29	the	the	DET
bjp-15259	162	30	neurobiology	neurobiology	NOUN
bjp-15259	162	31	of	of	ADP
bjp-15259	162	32	amyotrophic	amyotrophic	ADJ
bjp-15259	162	33	lateral	lateral	ADJ
bjp-15259	162	34	sclerosis	sclerosis	NOUN
bjp-15259	162	35	.	.	PUNCT
bjp-15259	163	1	eur	eur	PROPN
bjp-15259	163	2	j	j	PROPN
bjp-15259	163	3	neurosci	neurosci	PROPN
bjp-15259	163	4	.	.	PUNCT
bjp-15259	164	1	2010	2010	NUM
bjp-15259	164	2	;	;	PUNCT
bjp-15259	164	3	31	31	NUM
bjp-15259	164	4	:	:	SYM
bjp-15259	164	5	2247	2247	NUM
bjp-15259	164	6	-	-	SYM
bjp-15259	164	7	65	65	NUM
bjp-15259	164	8	.	.	PUNCT
bjp-15259	165	1	berman	berman	PROPN
bjp-15259	165	2	hm	hm	PROPN
bjp-15259	165	3	,	,	PUNCT
bjp-15259	165	4	westbrook	westbrook	PROPN
bjp-15259	165	5	j	j	PROPN
bjp-15259	165	6	,	,	PUNCT
bjp-15259	165	7	feng	feng	PROPN
bjp-15259	165	8	z	z	PROPN
bjp-15259	165	9	,	,	PUNCT
bjp-15259	165	10	gilliland	gilliland	VERB
bjp-15259	165	11	g	g	PROPN
bjp-15259	165	12	,	,	PUNCT
bjp-15259	165	13	bhat	bhat	PROPN
bjp-15259	165	14	tn	tn	PROPN
bjp-15259	165	15	,	,	PUNCT
bjp-15259	165	16	weissig	weissig	ADJ
bjp-15259	165	17	h	h	NOUN
bjp-15259	165	18	,	,	PUNCT
bjp-15259	165	19	shindyalov	shindyalov	VERB
bjp-15259	165	20	in	in	ADV
bjp-15259	165	21	,	,	PUNCT
bjp-15259	165	22	bourne	bourne	NOUN
bjp-15259	165	23	pe	pe	PROPN
bjp-15259	165	24	.	.	PUNCT
bjp-15259	166	1	the	the	DET
bjp-15259	166	2	protein	protein	NOUN
bjp-15259	166	3	data	data	PROPN
bjp-15259	166	4	bank	bank	NOUN
bjp-15259	166	5	.	.	PUNCT
bjp-15259	167	1	nucleic	nucleic	ADJ
bjp-15259	167	2	acids	acid	NOUN
bjp-15259	167	3	res	re	NOUN
bjp-15259	167	4	.	.	PROPN
bjp-15259	167	5	2000	2000	NUM
bjp-15259	167	6	;	;	PUNCT
bjp-15259	167	7	28	28	NUM
bjp-15259	167	8	:	:	SYM
bjp-15259	167	9	235	235	NUM
bjp-15259	167	10	-	-	SYM
bjp-15259	167	11	42	42	NUM
bjp-15259	167	12	.	.	PUNCT
bjp-15259	168	1	boeckmann	boeckmann	PROPN
bjp-15259	168	2	b	b	PROPN
bjp-15259	168	3	,	,	PUNCT
bjp-15259	168	4	bairoch	bairoch	NOUN
bjp-15259	168	5	a	a	NOUN
bjp-15259	168	6	,	,	PUNCT
bjp-15259	168	7	apweiler	apweiler	NOUN
bjp-15259	168	8	r	r	NOUN
bjp-15259	168	9	,	,	PUNCT
bjp-15259	168	10	blatter	blatter	PROPN
bjp-15259	168	11	mc	mc	PROPN
bjp-15259	168	12	,	,	PUNCT
bjp-15259	168	13	estreicher	estreicher	PROPN
bjp-15259	168	14	a	a	PRON
bjp-15259	168	15	,	,	PUNCT
bjp-15259	168	16	gasteiger	gasteiger	NOUN
bjp-15259	168	17	e	e	NOUN
bjp-15259	168	18	,	,	PUNCT
bjp-15259	168	19	martin	martin	PROPN
bjp-15259	168	20	mj	mj	PROPN
bjp-15259	168	21	,	,	PUNCT
bjp-15259	168	22	michoud	michoud	PROPN
bjp-15259	168	23	k	k	PROPN
bjp-15259	168	24	,	,	PUNCT
bjp-15259	168	25	o'donovan	o'donovan	PROPN
bjp-15259	168	26	c	c	X
bjp-15259	168	27	,	,	PUNCT
bjp-15259	168	28	phan	phan	PROPN
bjp-15259	168	29	i	i	PROPN
bjp-15259	168	30	,	,	PUNCT
bjp-15259	168	31	pilbout	pilbout	PROPN
bjp-15259	168	32	s	s	PROPN
bjp-15259	168	33	,	,	PUNCT
bjp-15259	168	34	schneider	schneider	PROPN
bjp-15259	168	35	m.	m.	PROPN
bjp-15259	168	36	the	the	DET
bjp-15259	168	37	swiss	swiss	ADJ
bjp-15259	168	38	-	-	PUNCT
bjp-15259	168	39	prot	prot	NOUN
bjp-15259	168	40	protein	protein	NOUN
bjp-15259	168	41	knowledgebase	knowledgebase	NOUN
bjp-15259	168	42	and	and	CCONJ
bjp-15259	168	43	its	its	PRON
bjp-15259	168	44	supplement	supplement	NOUN
bjp-15259	168	45	trembl	trembl	NOUN
bjp-15259	168	46	in	in	ADP
bjp-15259	168	47	2003	2003	NUM
bjp-15259	168	48	.	.	PUNCT
bjp-15259	169	1	nucleic	nucleic	ADJ
bjp-15259	169	2	acids	acid	NOUN
bjp-15259	169	3	res	re	NOUN
bjp-15259	169	4	.	.	PUNCT
bjp-15259	169	5	2003	2003	NUM
bjp-15259	169	6	;	;	PUNCT
bjp-15259	169	7	31	31	NUM
bjp-15259	169	8	:	:	SYM
bjp-15259	169	9	365	365	NUM
bjp-15259	169	10	-	-	NOUN
bjp-15259	169	11	70s	70s	NUM
bjp-15259	169	12	.	.	PUNCT
bjp-15259	170	1	bruijn	bruijn	PROPN
bjp-15259	170	2	li	li	PROPN
bjp-15259	170	3	,	,	PUNCT
bjp-15259	170	4	miller	miller	PROPN
bjp-15259	170	5	tm	tm	PROPN
bjp-15259	170	6	,	,	PUNCT
bjp-15259	170	7	cleveland	cleveland	PROPN
bjp-15259	170	8	dw	dw	PROPN
bjp-15259	170	9	.	.	PUNCT
bjp-15259	170	10	unraveling	unravel	VERB
bjp-15259	170	11	the	the	DET
bjp-15259	170	12	mechanisms	mechanism	NOUN
bjp-15259	170	13	involved	involve	VERB
bjp-15259	170	14	in	in	ADP
bjp-15259	170	15	motor	motor	PROPN
bjp-15259	170	16	neuron	neuron	PROPN
bjp-15259	170	17	degeneration	degeneration	NOUN
bjp-15259	170	18	in	in	ADP
bjp-15259	170	19	als	al	NOUN
bjp-15259	170	20	.	.	PUNCT
bjp-15259	171	1	annu	annu	PROPN
bjp-15259	171	2	rev	rev	PROPN
bjp-15259	171	3	neurosci	neurosci	PROPN
bjp-15259	171	4	.	.	PUNCT
bjp-15259	172	1	2004	2004	NUM
bjp-15259	172	2	;	;	PUNCT
bjp-15259	172	3	27	27	NUM
bjp-15259	172	4	:	:	SYM
bjp-15259	172	5	723	723	NUM
bjp-15259	172	6	-	-	SYM
bjp-15259	172	7	49	49	NUM
bjp-15259	172	8	.	.	PUNCT
bjp-15259	173	1	capriotti	capriotti	PROPN
bjp-15259	173	2	e	e	PROPN
bjp-15259	173	3	,	,	PUNCT
bjp-15259	173	4	fariselli	fariselli	VERB
bjp-15259	173	5	p	p	NOUN
bjp-15259	173	6	,	,	PUNCT
bjp-15259	173	7	casadio	casadio	PROPN
bjp-15259	173	8	r.	r.	PROPN
bjp-15259	173	9	i	i	PROPN
bjp-15259	173	10	-	-	PUNCT
bjp-15259	173	11	mutant2.0	mutant2.0	PROPN
bjp-15259	173	12	:	:	PUNCT
bjp-15259	173	13	predicting	predict	VERB
bjp-15259	173	14	stability	stability	NOUN
bjp-15259	173	15	changes	change	VERB
bjp-15259	173	16	upon	upon	SCONJ
bjp-15259	173	17	mutation	mutation	NOUN
bjp-15259	173	18	from	from	ADP
bjp-15259	173	19	the	the	DET
bjp-15259	173	20	protein	protein	NOUN
bjp-15259	173	21	sequence	sequence	NOUN
bjp-15259	173	22	or	or	CCONJ
bjp-15259	173	23	structure	structure	NOUN
bjp-15259	173	24	.	.	PUNCT
bjp-15259	174	1	nucleic	nucleic	ADJ
bjp-15259	174	2	acids	acid	NOUN
bjp-15259	174	3	res	re	NOUN
bjp-15259	174	4	.	.	PUNCT
bjp-15259	174	5	2005	2005	NUM
bjp-15259	174	6	;	;	PUNCT
bjp-15259	174	7	33	33	NUM
bjp-15259	174	8	:	:	SYM
bjp-15259	174	9	306	306	NUM
bjp-15259	174	10	-	-	SYM
bjp-15259	174	11	10	10	NUM
bjp-15259	174	12	.	.	PUNCT
bjp-15259	175	1	capriotti	capriotti	PROPN
bjp-15259	175	2	e	e	PROPN
bjp-15259	175	3	,	,	PUNCT
bjp-15259	175	4	fariselli	fariselli	VERB
bjp-15259	175	5	p	p	X
bjp-15259	175	6	,	,	PUNCT
bjp-15259	175	7	rossi	rossi	PROPN
bjp-15259	175	8	i.	i.	PROPN
bjp-15259	175	9	a	a	DET
bjp-15259	175	10	three	three	NUM
bjp-15259	175	11	-	-	PUNCT
bjp-15259	175	12	state	state	NOUN
bjp-15259	175	13	prediction	prediction	NOUN
bjp-15259	175	14	of	of	ADP
bjp-15259	175	15	single	single	ADJ
bjp-15259	175	16	point	point	NOUN
bjp-15259	175	17	mutations	mutation	NOUN
bjp-15259	175	18	on	on	ADP
bjp-15259	175	19	protein	protein	NOUN
bjp-15259	175	20	stability	stability	NOUN
bjp-15259	175	21	changes	change	NOUN
bjp-15259	175	22	,	,	PUNCT
bjp-15259	175	23	bmc	bmc	ADJ
bjp-15259	175	24	bioinformatics	bioinformatics	NOUN
bjp-15259	175	25	.	.	PUNCT
bjp-15259	175	26	2008	2008	NUM
bjp-15259	175	27	;	;	PUNCT
bjp-15259	175	28	26	26	NUM
bjp-15259	175	29	:	:	PUNCT
bjp-15259	175	30	56	56	NUM
bjp-15259	175	31	-	-	SYM
bjp-15259	175	32	59	59	NUM
bjp-15259	175	33	.	.	PUNCT
bjp-15259	176	1	carlson	carlson	PROPN
bjp-15259	176	2	ha	ha	PROPN
bjp-15259	176	3	,	,	PUNCT
bjp-15259	176	4	mccammon	mccammon	PROPN
bjp-15259	176	5	ja	ja	PROPN
bjp-15259	176	6	.	.	PUNCT
bjp-15259	177	1	accommodating	accommodate	VERB
bjp-15259	177	2	protein	protein	NOUN
bjp-15259	177	3	flexibility	flexibility	NOUN
bjp-15259	177	4	in	in	ADP
bjp-15259	177	5	computational	computational	ADJ
bjp-15259	177	6	drug	drug	NOUN
bjp-15259	177	7	design	design	NOUN
bjp-15259	177	8	.	.	PUNCT
bjp-15259	178	1	mol	mol	ADP
bjp-15259	178	2	pharmacol	pharmacol	PROPN
bjp-15259	178	3	.	.	PROPN
bjp-15259	179	1	2000	2000	NUM
bjp-15259	179	2	;	;	PUNCT
bjp-15259	179	3	57	57	NUM
bjp-15259	179	4	:	:	PUNCT
bjp-15259	179	5	213	213	NUM
bjp-15259	179	6	-	-	SYM
bjp-15259	179	7	18	18	NUM
bjp-15259	179	8	.	.	PUNCT
bjp-15259	180	1	cavallo	cavallo	VERB
bjp-15259	180	2	a	a	PRON
bjp-15259	180	3	,	,	PUNCT
bjp-15259	180	4	martin	martin	PROPN
bjp-15259	180	5	ac	ac	PROPN
bjp-15259	180	6	.	.	PUNCT
bjp-15259	181	1	mapping	mapping	NOUN
bjp-15259	181	2	snps	snps	PROPN
bjp-15259	181	3	to	to	ADP
bjp-15259	181	4	protein	protein	NOUN
bjp-15259	181	5	sequence	sequence	NOUN
bjp-15259	181	6	and	and	CCONJ
bjp-15259	181	7	structure	structure	NOUN
bjp-15259	181	8	data	datum	NOUN
bjp-15259	181	9	.	.	PUNCT
bjp-15259	182	1	bioinformatics	bioinformatic	NOUN
bjp-15259	182	2	.	.	PUNCT
bjp-15259	183	1	2005	2005	NUM
bjp-15259	183	2	;	;	PUNCT
bjp-15259	183	3	21	21	NUM
bjp-15259	183	4	:	:	SYM
bjp-15259	183	5	1443	1443	NUM
bjp-15259	183	6	-	-	SYM
bjp-15259	183	7	50	50	NUM
bjp-15259	183	8	.	.	PUNCT
bjp-15259	184	1	dejesus	dejesus	PROPN
bjp-15259	184	2	-	-	PUNCT
bjp-15259	184	3	hernandez	hernandez	PROPN
bjp-15259	184	4	m	m	PROPN
bjp-15259	184	5	,	,	PUNCT
bjp-15259	184	6	mackenzie	mackenzie	PROPN
bjp-15259	184	7	ir	ir	PROPN
bjp-15259	184	8	,	,	PUNCT
bjp-15259	184	9	boeve	boeve	NOUN
bjp-15259	184	10	bf	bf	NOUN
bjp-15259	184	11	,	,	PUNCT
bjp-15259	184	12	boxer	boxer	PROPN
bjp-15259	184	13	al	al	PROPN
bjp-15259	184	14	,	,	PUNCT
bjp-15259	184	15	baker	baker	PROPN
bjp-15259	184	16	m.	m.	PROPN
bjp-15259	184	17	expanded	expand	VERB
bjp-15259	184	18	ggggcc	ggggcc	NOUN
bjp-15259	184	19	hexanucleotide	hexanucleotide	ADJ
bjp-15259	184	20	repeat	repeat	NOUN
bjp-15259	184	21	in	in	ADP
bjp-15259	184	22	noncoding	noncoding	ADJ
bjp-15259	184	23	region	region	NOUN
bjp-15259	184	24	of	of	ADP
bjp-15259	184	25	c9orf72	c9orf72	PROPN
bjp-15259	184	26	causes	cause	NOUN
bjp-15259	184	27	chromosome	chromosome	NOUN
bjp-15259	184	28	9plinked	9plinked	NUM
bjp-15259	184	29	ftd	ftd	NOUN
bjp-15259	184	30	and	and	CCONJ
bjp-15259	184	31	als	als	PROPN
bjp-15259	184	32	.	.	PUNCT
bjp-15259	184	33	neuron	neuron	PROPN
bjp-15259	184	34	2011	2011	NUM
bjp-15259	184	35	;	;	PUNCT
bjp-15259	184	36	72	72	NUM
bjp-15259	184	37	:	:	SYM
bjp-15259	184	38	245	245	NUM
bjp-15259	184	39	-	-	SYM
bjp-15259	184	40	56	56	NUM
bjp-15259	184	41	.	.	PUNCT
bjp-15259	185	1	delarue	delarue	PROPN
bjp-15259	185	2	m	m	PROPN
bjp-15259	185	3	,	,	PUNCT
bjp-15259	185	4	dumas	dumas	PROPN
bjp-15259	185	5	p.	p.	PROPN
bjp-15259	185	6	on	on	ADP
bjp-15259	185	7	the	the	DET
bjp-15259	185	8	use	use	NOUN
bjp-15259	185	9	of	of	ADP
bjp-15259	185	10	low	low	ADJ
bjp-15259	185	11	-	-	PUNCT
bjp-15259	185	12	frequency	frequency	NOUN
bjp-15259	185	13	normal	normal	ADJ
bjp-15259	185	14	modes	mode	NOUN
bjp-15259	185	15	to	to	PART
bjp-15259	185	16	enforce	enforce	VERB
bjp-15259	185	17	collective	collective	ADJ
bjp-15259	185	18	movements	movement	NOUN
bjp-15259	185	19	in	in	ADP
bjp-15259	185	20	refining	refining	NOUN
bjp-15259	185	21	macromolecular	macromolecular	ADJ
bjp-15259	185	22	structural	structural	ADJ
bjp-15259	185	23	models	model	NOUN
bjp-15259	185	24	.	.	PUNCT
bjp-15259	186	1	proc	proc	PROPN
bjp-15259	186	2	natl	natl	PROPN
bjp-15259	186	3	acad	acad	PROPN
bjp-15259	186	4	sci	sci	PROPN
bjp-15259	186	5	usa	usa	PROPN
bjp-15259	186	6	.	.	PROPN
bjp-15259	186	7	2004	2004	NUM
bjp-15259	186	8	;	;	PUNCT
bjp-15259	186	9	101	101	NUM
bjp-15259	186	10	:	:	PUNCT
bjp-15259	186	11	6957	6957	NUM
bjp-15259	186	12	-	-	SYM
bjp-15259	186	13	62	62	NUM
bjp-15259	186	14	.	.	PUNCT
bjp-15259	187	1	dion	dion	NOUN
bjp-15259	187	2	pa	pa	PROPN
bjp-15259	187	3	,	,	PUNCT
bjp-15259	187	4	daoud	daoud	PROPN
bjp-15259	187	5	h	h	PROPN
bjp-15259	187	6	,	,	PUNCT
bjp-15259	187	7	rouleau	rouleau	PROPN
bjp-15259	187	8	ga	ga	PROPN
bjp-15259	187	9	.	.	PUNCT
bjp-15259	188	1	genetics	genetics	PROPN
bjp-15259	188	2	of	of	ADP
bjp-15259	188	3	motor	motor	PROPN
bjp-15259	188	4	neuron	neuron	NOUN
bjp-15259	188	5	disorders	disorder	NOUN
bjp-15259	188	6	:	:	PUNCT
bjp-15259	188	7	new	new	ADJ
bjp-15259	188	8	insights	insight	NOUN
bjp-15259	188	9	into	into	ADP
bjp-15259	188	10	pathogenic	pathogenic	ADJ
bjp-15259	188	11	mechanisms	mechanism	NOUN
bjp-15259	188	12	.	.	PUNCT
bjp-15259	189	1	nat	nat	PROPN
bjp-15259	189	2	rev	rev	PROPN
bjp-15259	189	3	genet	genet	PROPN
bjp-15259	189	4	.	.	PUNCT
bjp-15259	190	1	2009	2009	NUM
bjp-15259	190	2	;	;	PUNCT
bjp-15259	190	3	10	10	NUM
bjp-15259	190	4	:	:	SYM
bjp-15259	190	5	769	769	NUM
bjp-15259	190	6	-	-	SYM
bjp-15259	190	7	82	82	NUM
bjp-15259	190	8	.	.	PUNCT
bjp-15259	191	1	greenway	greenway	PROPN
bjp-15259	191	2	mj	mj	PROPN
bjp-15259	191	3	,	,	PUNCT
bjp-15259	191	4	alexander	alexander	PROPN
bjp-15259	191	5	md	md	PROPN
bjp-15259	191	6	,	,	PUNCT
bjp-15259	191	7	ennis	ennis	PROPN
bjp-15259	191	8	s	s	PART
bjp-15259	191	9	,	,	PUNCT
bjp-15259	191	10	traynor	traynor	NOUN
bjp-15259	191	11	bj	bj	VERB
bjp-15259	191	12	,	,	PUNCT
bjp-15259	191	13	corr	corr	PROPN
bjp-15259	191	14	b	b	PROPN
bjp-15259	191	15	,	,	PUNCT
bjp-15259	191	16	frost	frost	ADJ
bjp-15259	191	17	e	e	NOUN
bjp-15259	191	18	,	,	PUNCT
bjp-15259	191	19	green	green	PROPN
bjp-15259	191	20	a	a	PROPN
bjp-15259	191	21	,	,	PUNCT
bjp-15259	191	22	hardiman	hardiman	PROPN
bjp-15259	191	23	o.	o.	PROPN
bjp-15259	191	24	a	a	DET
bjp-15259	191	25	novel	novel	ADJ
bjp-15259	191	26	candidate	candidate	NOUN
bjp-15259	191	27	region	region	NOUN
bjp-15259	191	28	for	for	ADP
bjp-15259	191	29	als	als	NOUN
bjp-15259	191	30	on	on	ADP
bjp-15259	191	31	chromosome	chromosome	NOUN
bjp-15259	191	32	14q11.2	14q11.2	NUM
bjp-15259	191	33	.	.	PUNCT
bjp-15259	191	34	neurology	neurology	NOUN
bjp-15259	191	35	2004	2004	NUM
bjp-15259	191	36	;	;	PUNCT
bjp-15259	191	37	63	63	NUM
bjp-15259	191	38	:	:	SYM
bjp-15259	191	39	1936	1936	NUM
bjp-15259	191	40	-	-	SYM
bjp-15259	191	41	38	38	NUM
bjp-15259	191	42	.	.	PUNCT
bjp-15259	192	1	han	han	PROPN
bjp-15259	192	2	jh	jh	PROPN
bjp-15259	192	3	,	,	PUNCT
bjp-15259	192	4	kerrison	kerrison	PROPN
bjp-15259	192	5	n	n	CCONJ
bjp-15259	192	6	,	,	PUNCT
bjp-15259	192	7	chothia	chothia	PROPN
bjp-15259	192	8	c	c	PROPN
bjp-15259	192	9	,	,	PUNCT
bjp-15259	192	10	teichmann	teichmann	PROPN
bjp-15259	192	11	sa	sa	PROPN
bjp-15259	192	12	.	.	PUNCT
bjp-15259	193	1	divergence	divergence	NOUN
bjp-15259	193	2	of	of	ADP
bjp-15259	193	3	interdomain	interdomain	NOUN
bjp-15259	193	4	geometry	geometry	NOUN
bjp-15259	193	5	in	in	ADP
bjp-15259	193	6	two	two	NUM
bjp-15259	193	7	-	-	PUNCT
bjp-15259	193	8	domain	domain	NOUN
bjp-15259	193	9	proteins	protein	NOUN
bjp-15259	193	10	.	.	PUNCT
bjp-15259	194	1	structure	structure	NOUN
bjp-15259	194	2	2006	2006	NUM
bjp-15259	194	3	;	;	PUNCT
bjp-15259	194	4	14	14	NUM
bjp-15259	194	5	:	:	SYM
bjp-15259	194	6	935	935	NUM
bjp-15259	194	7	-	-	SYM
bjp-15259	194	8	45	45	NUM
bjp-15259	194	9	.	.	PUNCT
bjp-15259	195	1	hallahan	hallahan	PROPN
bjp-15259	195	2	tw	tw	PROPN
bjp-15259	195	3	,	,	PUNCT
bjp-15259	195	4	shapiro	shapiro	PROPN
bjp-15259	195	5	r	r	PROPN
bjp-15259	195	6	,	,	PUNCT
bjp-15259	195	7	vallee	vallee	PROPN
bjp-15259	195	8	bl	bl	PROPN
bjp-15259	195	9	.	.	PUNCT
bjp-15259	196	1	dual	dual	ADJ
bjp-15259	196	2	site	site	NOUN
bjp-15259	196	3	model	model	NOUN
bjp-15259	196	4	for	for	ADP
bjp-15259	196	5	the	the	DET
bjp-15259	196	6	organogenic	organogenic	ADJ
bjp-15259	196	7	activity	activity	NOUN
bjp-15259	196	8	of	of	ADP
bjp-15259	196	9	angiogenin	angiogenin	NOUN
bjp-15259	196	10	.	.	PUNCT
bjp-15259	197	1	proc	proc	PROPN
bjp-15259	197	2	natl	natl	PROPN
bjp-15259	197	3	acad	acad	PROPN
bjp-15259	197	4	sci	sci	PROPN
bjp-15259	197	5	usa	usa	PROPN
bjp-15259	197	6	.	.	PROPN
bjp-15259	197	7	1991	1991	NUM
bjp-15259	197	8	;	;	PUNCT
bjp-15259	197	9	88	88	NUM
bjp-15259	197	10	:	:	SYM
bjp-15259	197	11	2222	2222	NUM
bjp-15259	197	12	-	-	SYM
bjp-15259	197	13	26	26	NUM
bjp-15259	197	14	.	.	PUNCT
bjp-15259	198	1	hallahan	hallahan	PROPN
bjp-15259	198	2	tw	tw	PROPN
bjp-15259	198	3	,	,	PUNCT
bjp-15259	198	4	shapiro	shapiro	PROPN
bjp-15259	198	5	r	r	PROPN
bjp-15259	198	6	,	,	PUNCT
bjp-15259	198	7	strydom	strydom	NOUN
bjp-15259	198	8	dj	dj	PROPN
bjp-15259	198	9	,	,	PUNCT
bjp-15259	198	10	vallee	vallee	PROPN
bjp-15259	198	11	bl	bl	PROPN
bjp-15259	198	12	.	.	PUNCT
bjp-15259	199	1	importance	importance	NOUN
bjp-15259	199	2	of	of	ADP
bjp-15259	199	3	asparagine-61	asparagine-61	PROPN
bjp-15259	199	4	and	and	CCONJ
bjp-15259	199	5	asparagine-109	asparagine-109	ADJ
bjp-15259	199	6	to	to	ADP
bjp-15259	199	7	the	the	DET
bjp-15259	199	8	angiogenic	angiogenic	ADJ
bjp-15259	199	9	activity	activity	NOUN
bjp-15259	199	10	of	of	ADP
bjp-15259	199	11	human	human	ADJ
bjp-15259	199	12	angiogenin	angiogenin	NOUN
bjp-15259	199	13	.	.	PUNCT
bjp-15259	200	1	biochemistry	biochemistry	NOUN
bjp-15259	200	2	1992	1992	NUM
bjp-15259	200	3	;	;	PUNCT
bjp-15259	200	4	31	31	NUM
bjp-15259	200	5	:	:	SYM
bjp-15259	200	6	802229	802229	NUM
bjp-15259	200	7	.	.	PUNCT
bjp-15259	201	1	hinkle	hinkle	PROPN
bjp-15259	201	2	a	a	PRON
bjp-15259	201	3	,	,	PUNCT
bjp-15259	201	4	tobacman	tobacman	NOUN
bjp-15259	201	5	ls	ls	PROPN
bjp-15259	201	6	.	.	PUNCT
bjp-15259	201	7	folding	fold	VERB
bjp-15259	201	8	and	and	CCONJ
bjp-15259	201	9	function	function	NOUN
bjp-15259	201	10	of	of	ADP
bjp-15259	201	11	the	the	DET
bjp-15259	201	12	troponin	troponin	ADJ
bjp-15259	201	13	tail	tail	NOUN
bjp-15259	201	14	domain	domain	NOUN
bjp-15259	201	15	,	,	PUNCT
bjp-15259	201	16	effects	effect	NOUN
bjp-15259	201	17	of	of	ADP
bjp-15259	201	18	cardiomyopathic	cardiomyopathic	ADJ
bjp-15259	201	19	troponin	troponin	PROPN
bjp-15259	201	20	t	t	NOUN
bjp-15259	201	21	mutations	mutation	NOUN
bjp-15259	201	22	.	.	PUNCT
bjp-15259	202	1	j	j	PROPN
bjp-15259	202	2	biol	biol	PROPN
bjp-15259	202	3	chem	chem	NOUN
bjp-15259	202	4	.	.	PUNCT
bjp-15259	203	1	2003	2003	NUM
bjp-15259	203	2	;	;	PUNCT
bjp-15259	203	3	278	278	NUM
bjp-15259	203	4	:	:	PUNCT
bjp-15259	203	5	506	506	NUM
bjp-15259	203	6	-	-	SYM
bjp-15259	203	7	13	13	NUM
bjp-15259	203	8	.	.	PUNCT
bjp-15259	204	1	ivan	ivan	PROPN
bjp-15259	204	2	a.	a.	PROPN
bjp-15259	204	3	adzhubei	adzhubei	PROPN
bjp-15259	204	4	,	,	PUNCT
bjp-15259	204	5	steffen	steffen	PROPN
bjp-15259	204	6	s	s	PROPN
bjp-15259	204	7	,	,	PUNCT
bjp-15259	204	8	leonid	leonid	PROPN
bjp-15259	204	9	p.	p.	PROPN
bjp-15259	205	1	a	a	DET
bjp-15259	205	2	method	method	NOUN
bjp-15259	205	3	and	and	CCONJ
bjp-15259	205	4	server	server	VERB
bjp-15259	205	5	388	388	NUM
bjp-15259	205	6	bangladesh	bangladesh	NOUN
bjp-15259	205	7	j	j	PROPN
bjp-15259	205	8	pharmacol	pharmacol	PROPN
bjp-15259	205	9	2013	2013	NUM
bjp-15259	205	10	;	;	PUNCT
bjp-15259	205	11	8	8	NUM
bjp-15259	205	12	:	:	PUNCT
bjp-15259	205	13	382	382	NUM
bjp-15259	205	14	-	-	SYM
bjp-15259	205	15	389	389	NUM
bjp-15259	205	16	figure	figure	NOUN
bjp-15259	205	17	4	4	NUM
bjp-15259	205	18	:	:	PUNCT
bjp-15259	205	19	comparison	comparison	NOUN
bjp-15259	205	20	of	of	ADP
bjp-15259	205	21	normalized	normalize	VERB
bjp-15259	205	22	mean	mean	ADJ
bjp-15259	205	23	square	square	ADJ
bjp-15259	205	24	displacement	displacement	NOUN
bjp-15259	205	25	of	of	ADP
bjp-15259	205	26	binding	bind	VERB
bjp-15259	205	27	amino	amino	ADJ
bjp-15259	205	28	acids	acid	NOUN
bjp-15259	205	29	of	of	ADP
bjp-15259	205	30	native	native	ADJ
bjp-15259	205	31	and	and	CCONJ
bjp-15259	205	32	mutant	mutant	ADJ
bjp-15259	205	33	angiogenin	angiogenin	NOUN
bjp-15259	205	34	protein	protein	NOUN
bjp-15259	205	35	for	for	ADP
bjp-15259	205	36	predicting	predict	VERB
bjp-15259	205	37	damaging	damaging	ADJ
bjp-15259	205	38	missense	missense	NOUN
bjp-15259	205	39	mutations	mutation	NOUN
bjp-15259	205	40	.	.	PUNCT
bjp-15259	206	1	nat	nat	NOUN
bjp-15259	206	2	methods	method	NOUN
bjp-15259	206	3	.	.	PUNCT
bjp-15259	207	1	2010	2010	NUM
bjp-15259	207	2	;	;	PUNCT
bjp-15259	207	3	7	7	NUM
bjp-15259	207	4	:	:	SYM
bjp-15259	207	5	248	248	NUM
bjp-15259	207	6	-	-	SYM
bjp-15259	207	7	49	49	NUM
bjp-15259	207	8	.	.	PUNCT
bjp-15259	208	1	kieran	kieran	PROPN
bjp-15259	208	2	d	d	PROPN
bjp-15259	208	3	,	,	PUNCT
bjp-15259	208	4	sebastia	sebastia	PROPN
bjp-15259	208	5	j	j	PROPN
bjp-15259	208	6	,	,	PUNCT
bjp-15259	208	7	greenway	greenway	PROPN
bjp-15259	208	8	mj	mj	PROPN
bjp-15259	208	9	,	,	PUNCT
bjp-15259	208	10	king	king	PROPN
bjp-15259	208	11	ma	ma	PROPN
bjp-15259	208	12	,	,	PUNCT
bjp-15259	208	13	connaughton	connaughton	NOUN
bjp-15259	208	14	d	d	PROPN
bjp-15259	208	15	,	,	PUNCT
bjp-15259	208	16	concannon	concannon	NOUN
bjp-15259	208	17	cg	cg	PROPN
bjp-15259	208	18	,	,	PUNCT
bjp-15259	208	19	fenner	fenner	PROPN
bjp-15259	208	20	b	b	PROPN
bjp-15259	208	21	,	,	PUNCT
bjp-15259	208	22	hardiman	hardiman	PROPN
bjp-15259	208	23	o	o	PROPN
bjp-15259	208	24	,	,	PUNCT
bjp-15259	208	25	prehn	prehn	PROPN
bjp-15259	208	26	jh	jh	PROPN
bjp-15259	208	27	.	.	PUNCT
bjp-15259	209	1	control	control	PROPN
bjp-15259	209	2	of	of	ADP
bjp-15259	209	3	motoneuron	motoneuron	NOUN
bjp-15259	209	4	survival	survival	NOUN
bjp-15259	209	5	by	by	ADP
bjp-15259	209	6	angiogenin	angiogenin	PROPN
bjp-15259	209	7	.	.	PUNCT
bjp-15259	210	1	j	j	PROPN
bjp-15259	210	2	neurosci	neurosci	PROPN
bjp-15259	210	3	.	.	PUNCT
bjp-15259	210	4	2008	2008	NUM
bjp-15259	210	5	;	;	PUNCT
bjp-15259	210	6	28	28	NUM
bjp-15259	210	7	:	:	SYM
bjp-15259	210	8	14056	14056	NUM
bjp-15259	210	9	-	-	SYM
bjp-15259	210	10	61	61	NUM
bjp-15259	210	11	.	.	PUNCT
bjp-15259	211	1	kishikawa	kishikawa	PROPN
bjp-15259	211	2	h	h	PROPN
bjp-15259	211	3	,	,	PUNCT
bjp-15259	211	4	wu	wu	PROPN
bjp-15259	211	5	d	d	PROPN
bjp-15259	211	6	,	,	PUNCT
bjp-15259	211	7	hu	hu	PROPN
bjp-15259	212	1	gf	gf	PROPN
bjp-15259	212	2	.	.	PUNCT
bjp-15259	213	1	targeting	target	VERB
bjp-15259	213	2	angiogenin	angiogenin	NOUN
bjp-15259	213	3	in	in	ADP
bjp-15259	213	4	therapy	therapy	NOUN
bjp-15259	213	5	of	of	ADP
bjp-15259	213	6	amyotropic	amyotropic	NOUN
bjp-15259	213	7	lateral	lateral	ADJ
bjp-15259	213	8	sclerosis	sclerosis	NOUN
bjp-15259	213	9	.	.	PUNCT
bjp-15259	214	1	expert	expert	NOUN
bjp-15259	214	2	opin	opin	NOUN
bjp-15259	214	3	ther	ther	NOUN
bjp-15259	214	4	targets	target	NOUN
bjp-15259	214	5	.	.	PUNCT
bjp-15259	215	1	2008	2008	NUM
bjp-15259	215	2	;	;	PUNCT
bjp-15259	215	3	12	12	NUM
bjp-15259	215	4	:	:	SYM
bjp-15259	215	5	1229	1229	NUM
bjp-15259	215	6	-	-	SYM
bjp-15259	215	7	42	42	NUM
bjp-15259	215	8	.	.	PUNCT
bjp-15259	216	1	kobe	kobe	PROPN
bjp-15259	216	2	b	b	PROPN
bjp-15259	216	3	,	,	PUNCT
bjp-15259	216	4	deisenhofer	deisenhofer	NOUN
bjp-15259	216	5	j.	j.	PROPN
bjp-15259	216	6	mechanism	mechanism	NOUN
bjp-15259	216	7	of	of	ADP
bjp-15259	216	8	ribonuclease	ribonuclease	NOUN
bjp-15259	216	9	inhibition	inhibition	NOUN
bjp-15259	216	10	by	by	ADP
bjp-15259	216	11	ribonuclease	ribonuclease	NOUN
bjp-15259	216	12	inhibitor	inhibitor	NOUN
bjp-15259	216	13	protein	protein	NOUN
bjp-15259	216	14	based	base	VERB
bjp-15259	216	15	on	on	ADP
bjp-15259	216	16	the	the	DET
bjp-15259	216	17	crystal	crystal	NOUN
bjp-15259	216	18	structure	structure	NOUN
bjp-15259	216	19	of	of	ADP
bjp-15259	216	20	its	its	PRON
bjp-15259	216	21	complex	complex	NOUN
bjp-15259	216	22	with	with	ADP
bjp-15259	216	23	ribonuclease	ribonuclease	NOUN
bjp-15259	216	24	.	.	PUNCT
bjp-15259	216	25	am	be	AUX
bjp-15259	216	26	j	j	PROPN
bjp-15259	216	27	mol	mol	ADP
bjp-15259	216	28	biol	biol	PROPN
bjp-15259	216	29	.	.	PUNCT
bjp-15259	217	1	1996	1996	NUM
bjp-15259	217	2	;	;	PUNCT
bjp-15259	217	3	264	264	NUM
bjp-15259	217	4	:	:	PUNCT
bjp-15259	217	5	1028	1028	NUM
bjp-15259	217	6	-	-	SYM
bjp-15259	217	7	43	43	NUM
bjp-15259	217	8	.	.	PUNCT
bjp-15259	218	1	kumar	kumar	PROPN
bjp-15259	218	2	p	p	PROPN
bjp-15259	218	3	,	,	PUNCT
bjp-15259	218	4	henikoff	henikoff	NOUN
bjp-15259	218	5	s	s	PROPN
bjp-15259	218	6	,	,	PUNCT
bjp-15259	218	7	ng	ng	PROPN
bjp-15259	218	8	pc	pc	PROPN
bjp-15259	218	9	.	.	PUNCT
bjp-15259	218	10	predicting	predict	VERB
bjp-15259	218	11	the	the	DET
bjp-15259	218	12	effects	effect	NOUN
bjp-15259	218	13	of	of	ADP
bjp-15259	218	14	coding	code	VERB
bjp-15259	218	15	non	non	ADJ
bjp-15259	218	16	-	-	ADJ
bjp-15259	218	17	synonymous	synonymous	ADJ
bjp-15259	218	18	variants	variant	NOUN
bjp-15259	218	19	on	on	ADP
bjp-15259	218	20	protein	protein	NOUN
bjp-15259	218	21	function	function	NOUN
bjp-15259	218	22	using	use	VERB
bjp-15259	218	23	the	the	DET
bjp-15259	218	24	sift	sift	ADJ
bjp-15259	218	25	algorithm	algorithm	NOUN
bjp-15259	218	26	.	.	PUNCT
bjp-15259	219	1	nat	nat	PROPN
bjp-15259	219	2	protoc	protoc	VERB
bjp-15259	219	3	.	.	PUNCT
bjp-15259	220	1	2009	2009	NUM
bjp-15259	220	2	;	;	PUNCT
bjp-15259	220	3	4	4	NUM
bjp-15259	220	4	:	:	SYM
bjp-15259	220	5	1073	1073	NUM
bjp-15259	220	6	-	-	SYM
bjp-15259	220	7	81	81	NUM
bjp-15259	220	8	.	.	PUNCT
bjp-15259	221	1	lindahl	lindahl	PROPN
bjp-15259	221	2	e	e	NOUN
bjp-15259	221	3	,	,	PUNCT
bjp-15259	221	4	azuara	azuara	NOUN
bjp-15259	221	5	c	c	NOUN
bjp-15259	221	6	,	,	PUNCT
bjp-15259	221	7	koehl	koehl	NOUN
bjp-15259	221	8	p	p	NOUN
bjp-15259	221	9	,	,	PUNCT
bjp-15259	221	10	delarue	delarue	ADJ
bjp-15259	221	11	m.	m.	NOUN
bjp-15259	221	12	nomad	nomad	PROPN
bjp-15259	221	13	-	-	PUNCT
bjp-15259	221	14	ref	ref	NOUN
bjp-15259	221	15	:	:	PUNCT
bjp-15259	221	16	visualization	visualization	NOUN
bjp-15259	221	17	,	,	PUNCT
bjp-15259	221	18	deformation	deformation	NOUN
bjp-15259	221	19	and	and	CCONJ
bjp-15259	221	20	refinement	refinement	NOUN
bjp-15259	221	21	of	of	ADP
bjp-15259	221	22	macromolecular	macromolecular	NOUN
bjp-15259	221	23	structures	structure	NOUN
bjp-15259	221	24	based	base	VERB
bjp-15259	221	25	on	on	ADP
bjp-15259	221	26	all	all	DET
bjp-15259	221	27	-	-	PUNCT
bjp-15259	221	28	atom	atom	NOUN
bjp-15259	221	29	normal	normal	ADJ
bjp-15259	221	30	mode	mode	NOUN
bjp-15259	221	31	analysis	analysis	NOUN
bjp-15259	221	32	.	.	PUNCT
bjp-15259	222	1	nucleic	nucleic	ADJ
bjp-15259	222	2	acids	acid	NOUN
bjp-15259	222	3	res	re	NOUN
bjp-15259	222	4	.	.	PUNCT
bjp-15259	222	5	2006	2006	NUM
bjp-15259	222	6	;	;	PUNCT
bjp-15259	222	7	34	34	NUM
bjp-15259	222	8	:	:	SYM
bjp-15259	222	9	52	52	NUM
bjp-15259	222	10	-	-	SYM
bjp-15259	222	11	56	56	NUM
bjp-15259	222	12	.	.	PUNCT
bjp-15259	223	1	moroianu	moroianu	PROPN
bjp-15259	223	2	j	j	PROPN
bjp-15259	223	3	,	,	PUNCT
bjp-15259	223	4	riordan	riordan	PROPN
bjp-15259	223	5	jf	jf	PROPN
bjp-15259	223	6	.	.	PROPN
bjp-15259	223	7	identification	identification	NOUN
bjp-15259	223	8	of	of	ADP
bjp-15259	223	9	the	the	DET
bjp-15259	223	10	nucleolar	nucleolar	ADJ
bjp-15259	223	11	targeting	targeting	NOUN
bjp-15259	223	12	signal	signal	NOUN
bjp-15259	223	13	of	of	ADP
bjp-15259	223	14	human	human	ADJ
bjp-15259	223	15	angiogenin	angiogenin	PROPN
bjp-15259	223	16	.	.	PUNCT
bjp-15259	224	1	biochem	biochem	PROPN
bjp-15259	224	2	biophys	biophys	PROPN
bjp-15259	224	3	res	re	NOUN
bjp-15259	224	4	commun	commun	PROPN
bjp-15259	224	5	.	.	PUNCT
bjp-15259	224	6	1994	1994	NUM
bjp-15259	224	7	;	;	PUNCT
bjp-15259	224	8	203	203	NUM
bjp-15259	224	9	:	:	PUNCT
bjp-15259	224	10	1765	1765	NUM
bjp-15259	224	11	-	-	SYM
bjp-15259	224	12	72	72	NUM
bjp-15259	224	13	.	.	PUNCT
bjp-15259	225	1	ng	ng	PROPN
bjp-15259	225	2	pc	pc	PROPN
bjp-15259	225	3	,	,	PUNCT
bjp-15259	225	4	henikoff	henikoff	NOUN
bjp-15259	225	5	s.	s.	PROPN
bjp-15259	225	6	sift	sift	PROPN
bjp-15259	225	7	:	:	PUNCT
bjp-15259	225	8	predicting	predict	VERB
bjp-15259	225	9	amino	amino	NOUN
bjp-15259	225	10	acid	acid	NOUN
bjp-15259	225	11	changes	change	NOUN
bjp-15259	225	12	that	that	PRON
bjp-15259	225	13	affect	affect	VERB
bjp-15259	225	14	protein	protein	NOUN
bjp-15259	225	15	function	function	NOUN
bjp-15259	225	16	.	.	PUNCT
bjp-15259	226	1	nucleic	nucleic	ADJ
bjp-15259	226	2	acids	acid	NOUN
bjp-15259	226	3	res	re	NOUN
bjp-15259	226	4	.	.	PUNCT
bjp-15259	226	5	2003	2003	NUM
bjp-15259	226	6	;	;	PUNCT
bjp-15259	226	7	31	31	NUM
bjp-15259	226	8	:	:	SYM
bjp-15259	226	9	3812	3812	NUM
bjp-15259	226	10	-	-	SYM
bjp-15259	226	11	14	14	NUM
bjp-15259	226	12	.	.	PUNCT
bjp-15259	227	1	ng	ng	PROPN
bjp-15259	227	2	pc	pc	PROPN
bjp-15259	227	3	,	,	PUNCT
bjp-15259	227	4	henikoff	henikoff	PROPN
bjp-15259	227	5	s.	s.	PROPN
bjp-15259	227	6	predicting	predict	VERB
bjp-15259	227	7	deleterious	deleterious	ADJ
bjp-15259	227	8	amino	amino	NOUN
bjp-15259	227	9	acid	acid	NOUN
bjp-15259	227	10	substitutions	substitution	NOUN
bjp-15259	227	11	.	.	PUNCT
bjp-15259	228	1	genome	genome	NOUN
bjp-15259	228	2	res	re	NOUN
bjp-15259	228	3	.	.	PUNCT
bjp-15259	228	4	2001	2001	NUM
bjp-15259	228	5	;	;	PUNCT
bjp-15259	228	6	11	11	NUM
bjp-15259	228	7	:	:	SYM
bjp-15259	228	8	863	863	NUM
bjp-15259	228	9	-	-	SYM
bjp-15259	228	10	74	74	NUM
bjp-15259	228	11	.	.	PUNCT
bjp-15259	229	1	padhi	padhi	PROPN
bjp-15259	229	2	ak	ak	PROPN
bjp-15259	229	3	,	,	PUNCT
bjp-15259	229	4	kumar	kumar	PROPN
bjp-15259	229	5	h	h	PROPN
bjp-15259	229	6	,	,	PUNCT
bjp-15259	229	7	vasaikar	vasaikar	PROPN
bjp-15259	229	8	sv	sv	PROPN
bjp-15259	229	9	,	,	PUNCT
bjp-15259	229	10	jayaram	jayaram	PROPN
bjp-15259	229	11	b	b	PROPN
bjp-15259	229	12	,	,	PUNCT
bjp-15259	229	13	gomes	gomes	PROPN
bjp-15259	229	14	j.	j.	PROPN
bjp-15259	229	15	mechanisms	mechanism	NOUN
bjp-15259	229	16	of	of	ADP
bjp-15259	229	17	loss	loss	NOUN
bjp-15259	229	18	of	of	ADP
bjp-15259	229	19	functions	function	NOUN
bjp-15259	229	20	of	of	ADP
bjp-15259	229	21	human	human	ADJ
bjp-15259	229	22	angiogenin	angiogenin	NOUN
bjp-15259	229	23	variants	variant	NOUN
bjp-15259	229	24	implicated	implicate	VERB
bjp-15259	229	25	in	in	ADP
bjp-15259	229	26	amyotrophic	amyotrophic	ADJ
bjp-15259	229	27	lateral	lateral	ADJ
bjp-15259	229	28	sclerosis	sclerosis	NOUN
bjp-15259	229	29	.	.	PUNCT
bjp-15259	230	1	plos	plos	PROPN
bjp-15259	230	2	one	one	NUM
bjp-15259	230	3	.	.	PUNCT
bjp-15259	230	4	2012	2012	NUM
bjp-15259	230	5	;	;	PUNCT
bjp-15259	230	6	7	7	NUM
bjp-15259	230	7	:	:	PUNCT
bjp-15259	230	8	e32479	e32479	PROPN
bjp-15259	230	9	.	.	PUNCT
bjp-15259	231	1	parthasarathy	parthasarathy	PROPN
bjp-15259	231	2	s	s	PROPN
bjp-15259	231	3	,	,	PUNCT
bjp-15259	231	4	murthy	murthy	PROPN
bjp-15259	231	5	mr	mr	PROPN
bjp-15259	231	6	.	.	PROPN
bjp-15259	231	7	protein	protein	NOUN
bjp-15259	231	8	thermal	thermal	ADJ
bjp-15259	231	9	stability	stability	NOUN
bjp-15259	231	10	:	:	PUNCT
bjp-15259	231	11	insights	insight	NOUN
bjp-15259	231	12	from	from	ADP
bjp-15259	231	13	atomic	atomic	ADJ
bjp-15259	231	14	displacement	displacement	NOUN
bjp-15259	231	15	parameters	parameter	NOUN
bjp-15259	231	16	(	(	PUNCT
bjp-15259	231	17	b	b	NOUN
bjp-15259	231	18	values	value	NOUN
bjp-15259	231	19	)	)	PUNCT
bjp-15259	231	20	.	.	PUNCT
bjp-15259	232	1	protein	protein	NOUN
bjp-15259	232	2	eng	eng	PROPN
bjp-15259	232	3	.	.	PROPN
bjp-15259	232	4	2000	2000	NUM
bjp-15259	232	5	;	;	PUNCT
bjp-15259	232	6	13	13	NUM
bjp-15259	232	7	:	:	SYM
bjp-15259	232	8	9	9	NUM
bjp-15259	232	9	-	-	SYM
bjp-15259	232	10	13	13	NUM
bjp-15259	232	11	.	.	PUNCT
bjp-15259	233	1	ramensky	ramensky	PROPN
bjp-15259	233	2	v	v	PROPN
bjp-15259	233	3	,	,	PUNCT
bjp-15259	233	4	bork	bork	NOUN
bjp-15259	233	5	p	p	NOUN
bjp-15259	233	6	,	,	PUNCT
bjp-15259	233	7	sunyaev	sunyaev	PROPN
bjp-15259	233	8	s.	s.	PROPN
bjp-15259	233	9	human	human	PROPN
bjp-15259	233	10	non	non	ADJ
bjp-15259	233	11	-	-	ADJ
bjp-15259	233	12	synonymous	synonymous	ADJ
bjp-15259	233	13	snps	snps	NOUN
bjp-15259	233	14	:	:	PUNCT
bjp-15259	233	15	server	server	NOUN
bjp-15259	233	16	and	and	CCONJ
bjp-15259	233	17	survey	survey	NOUN
bjp-15259	233	18	.	.	PUNCT
bjp-15259	234	1	nucleic	nucleic	ADJ
bjp-15259	234	2	acids	acid	NOUN
bjp-15259	234	3	res	re	NOUN
bjp-15259	234	4	.	.	PUNCT
bjp-15259	234	5	2002	2002	NUM
bjp-15259	234	6	;	;	PUNCT
bjp-15259	234	7	30	30	NUM
bjp-15259	234	8	:	:	SYM
bjp-15259	234	9	3894900	3894900	NUM
bjp-15259	234	10	.	.	PUNCT
bjp-15259	235	1	renton	renton	PROPN
bjp-15259	235	2	ae	ae	PROPN
bjp-15259	235	3	,	,	PUNCT
bjp-15259	235	4	majounie	majounie	PROPN
bjp-15259	235	5	e	e	PROPN
bjp-15259	235	6	,	,	PUNCT
bjp-15259	235	7	waite	waite	PROPN
bjp-15259	235	8	a.	a.	PROPN
bjp-15259	235	9	simo´n	simo´n	PROPN
bjp-15259	235	10	-	-	PUNCT
bjp-15259	235	11	sa´nchez	sa´nchez	PROPN
bjp-15259	235	12	j	j	PROPN
bjp-15259	235	13	,	,	PUNCT
bjp-15259	235	14	rollinson	rollinson	NOUN
bjp-15259	235	15	s	s	PROPN
bjp-15259	235	16	,	,	PUNCT
bjp-15259	235	17	et	et	PROPN
bjp-15259	235	18	al	al	PROPN
bjp-15259	235	19	.	.	PUNCT
bjp-15259	236	1	a	a	DET
bjp-15259	236	2	hexanucleotide	hexanucleotide	ADJ
bjp-15259	236	3	repeat	repeat	NOUN
bjp-15259	236	4	expansion	expansion	NOUN
bjp-15259	236	5	in	in	ADP
bjp-15259	236	6	c9orf72	c9orf72	PROPN
bjp-15259	236	7	is	be	AUX
bjp-15259	236	8	the	the	DET
bjp-15259	236	9	cause	cause	NOUN
bjp-15259	236	10	of	of	ADP
bjp-15259	236	11	chromosome	chromosome	NOUN
bjp-15259	236	12	9p21	9p21	NOUN
bjp-15259	236	13	-	-	PUNCT
bjp-15259	236	14	linked	link	VERB
bjp-15259	236	15	als	als	NOUN
bjp-15259	236	16	-	-	PUNCT
bjp-15259	236	17	ftd	ftd	NOUN
bjp-15259	236	18	.	.	PROPN
bjp-15259	236	19	neuron	neuron	PROPN
bjp-15259	236	20	2011	2011	NUM
bjp-15259	236	21	;	;	PUNCT
bjp-15259	236	22	72	72	NUM
bjp-15259	236	23	:	:	PUNCT
bjp-15259	236	24	257	257	NUM
bjp-15259	236	25	-	-	SYM
bjp-15259	236	26	68	68	NUM
bjp-15259	236	27	.	.	PUNCT
bjp-15259	237	1	ringe	ringe	PROPN
bjp-15259	237	2	d	d	PROPN
bjp-15259	237	3	,	,	PUNCT
bjp-15259	237	4	petsko	petsko	PROPN
bjp-15259	237	5	ga	ga	PROPN
bjp-15259	237	6	.	.	PROPN
bjp-15259	237	7	study	study	NOUN
bjp-15259	237	8	of	of	ADP
bjp-15259	237	9	protein	protein	NOUN
bjp-15259	237	10	dynamics	dynamic	NOUN
bjp-15259	237	11	by	by	ADP
bjp-15259	237	12	x	x	NOUN
bjp-15259	237	13	-	-	NOUN
bjp-15259	237	14	ray	ray	NOUN
bjp-15259	237	15	diffraction	diffraction	NOUN
bjp-15259	237	16	.	.	PUNCT
bjp-15259	238	1	methods	method	NOUN
bjp-15259	238	2	enzymol	enzymol	PROPN
bjp-15259	238	3	.	.	PUNCT
bjp-15259	239	1	1986	1986	NUM
bjp-15259	239	2	;	;	PUNCT
bjp-15259	239	3	131	131	NUM
bjp-15259	239	4	:	:	SYM
bjp-15259	239	5	389	389	NUM
bjp-15259	239	6	-	-	SYM
bjp-15259	239	7	433	433	NUM
bjp-15259	239	8	.	.	PUNCT
bjp-15259	239	9	shapiro	shapiro	PROPN
bjp-15259	239	10	r.	r.	PROPN
bjp-15259	239	11	cytoplasmic	cytoplasmic	PROPN
bjp-15259	239	12	ribonuclease	ribonuclease	NOUN
bjp-15259	239	13	inhibitor	inhibitor	NOUN
bjp-15259	239	14	.	.	PUNCT
bjp-15259	240	1	meth	meth	NOUN
bjp-15259	240	2	enzymol	enzymol	PROPN
bjp-15259	240	3	.	.	PUNCT
bjp-15259	241	1	2001	2001	NUM
bjp-15259	241	2	;	;	PUNCT
bjp-15259	241	3	341	341	NUM
bjp-15259	241	4	:	:	PUNCT
bjp-15259	241	5	611	611	NUM
bjp-15259	241	6	-	-	SYM
bjp-15259	241	7	28	28	NUM
bjp-15259	241	8	.	.	PUNCT
bjp-15259	242	1	shapiro	shapiro	PROPN
bjp-15259	242	2	r	r	PROPN
bjp-15259	242	3	,	,	PUNCT
bjp-15259	242	4	riordan	riordan	PROPN
bjp-15259	242	5	jf	jf	PROPN
bjp-15259	242	6	,	,	PUNCT
bjp-15259	242	7	vallee	vallee	PROPN
bjp-15259	242	8	bl	bl	PROPN
bjp-15259	242	9	.	.	PUNCT
bjp-15259	243	1	characteristic	characteristic	ADJ
bjp-15259	243	2	ribonucleolytic	ribonucleolytic	ADJ
bjp-15259	243	3	activity	activity	NOUN
bjp-15259	243	4	of	of	ADP
bjp-15259	243	5	human	human	ADJ
bjp-15259	243	6	angiogenin	angiogenin	NOUN
bjp-15259	243	7	.	.	PUNCT
bjp-15259	244	1	biochemistry	biochemistry	NOUN
bjp-15259	244	2	1986	1986	NUM
bjp-15259	244	3	;	;	PUNCT
bjp-15259	244	4	25	25	NUM
bjp-15259	244	5	:	:	SYM
bjp-15259	244	6	352732	352732	NUM
bjp-15259	244	7	.	.	PUNCT
bjp-15259	245	1	sharma	sharma	PROPN
bjp-15259	245	2	s	s	PROPN
bjp-15259	245	3	,	,	PUNCT
bjp-15259	245	4	ding	de	VERB
bjp-15259	245	5	f	f	PROPN
bjp-15259	245	6	,	,	PUNCT
bjp-15259	245	7	nie	nie	PROPN
bjp-15259	245	8	h	h	PROPN
bjp-15259	245	9	,	,	PUNCT
bjp-15259	245	10	watson	watson	PROPN
bjp-15259	245	11	d	d	PROPN
bjp-15259	245	12	,	,	PUNCT
bjp-15259	245	13	unnithan	unnithan	ADP
bjp-15259	245	14	a	a	PRON
bjp-15259	245	15	,	,	PUNCT
bjp-15259	245	16	lopp	lopp	PROPN
bjp-15259	245	17	j	j	PROPN
bjp-15259	245	18	,	,	PUNCT
bjp-15259	245	19	pozefsky	pozefsky	PROPN
bjp-15259	245	20	d	d	PROPN
bjp-15259	245	21	,	,	PUNCT
bjp-15259	245	22	dokholyan	dokholyan	PROPN
bjp-15259	246	1	nv	nv	PROPN
bjp-15259	246	2	.	.	PROPN
bjp-15259	246	3	ifold	ifold	PROPN
bjp-15259	246	4	:	:	PUNCT
bjp-15259	246	5	a	a	DET
bjp-15259	246	6	platform	platform	NOUN
bjp-15259	246	7	for	for	ADP
bjp-15259	246	8	interactive	interactive	ADJ
bjp-15259	246	9	folding	folding	NOUN
bjp-15259	246	10	simulation	simulation	NOUN
bjp-15259	246	11	of	of	ADP
bjp-15259	246	12	proteins	protein	NOUN
bjp-15259	246	13	.	.	PUNCT
bjp-15259	247	1	bioinformatics	bioinformatics	NOUN
bjp-15259	247	2	.	.	PUNCT
bjp-15259	248	1	2006	2006	NUM
bjp-15259	248	2	;	;	PUNCT
bjp-15259	248	3	22	22	NUM
bjp-15259	248	4	:	:	SYM
bjp-15259	248	5	2693	2693	NUM
bjp-15259	248	6	-	-	SYM
bjp-15259	248	7	94	94	NUM
bjp-15259	248	8	.	.	PUNCT
bjp-15259	249	1	subramanian	subramanian	PROPN
bjp-15259	249	2	v	v	PROPN
bjp-15259	249	3	,	,	PUNCT
bjp-15259	249	4	crabtree	crabtree	PROPN
bjp-15259	249	5	b	b	PROPN
bjp-15259	249	6	,	,	PUNCT
bjp-15259	249	7	acharya	acharya	PROPN
bjp-15259	249	8	kr	kr	PROPN
bjp-15259	249	9	.	.	PROPN
bjp-15259	250	1	human	human	ADJ
bjp-15259	250	2	angiogenin	angiogenin	PROPN
bjp-15259	250	3	is	be	AUX
bjp-15259	250	4	a	a	DET
bjp-15259	250	5	neuroprotective	neuroprotective	ADJ
bjp-15259	250	6	factor	factor	NOUN
bjp-15259	250	7	and	and	CCONJ
bjp-15259	250	8	amyotrophic	amyotrophic	ADJ
bjp-15259	250	9	lateral	lateral	ADJ
bjp-15259	250	10	sclerosis	sclerosis	NOUN
bjp-15259	250	11	associated	associate	VERB
bjp-15259	250	12	angiogenin	angiogenin	NOUN
bjp-15259	250	13	variants	variant	NOUN
bjp-15259	250	14	affect	affect	VERB
bjp-15259	250	15	neurite	neurite	VERB
bjp-15259	250	16	extension/	extension/	NUM
bjp-15259	250	17	pathfinding	pathfinding	NOUN
bjp-15259	250	18	and	and	CCONJ
bjp-15259	250	19	survival	survival	NOUN
bjp-15259	250	20	of	of	ADP
bjp-15259	250	21	motor	motor	NOUN
bjp-15259	250	22	neurons	neuron	NOUN
bjp-15259	250	23	.	.	PUNCT
bjp-15259	251	1	hum	hum	PROPN
bjp-15259	251	2	mol	mol	ADP
bjp-15259	251	3	genet	genet	PROPN
bjp-15259	251	4	.	.	PUNCT
bjp-15259	252	1	2008	2008	NUM
bjp-15259	252	2	;	;	PUNCT
bjp-15259	252	3	17	17	NUM
bjp-15259	252	4	:	:	SYM
bjp-15259	252	5	130	130	NUM
bjp-15259	252	6	-	-	SYM
bjp-15259	252	7	49	49	NUM
bjp-15259	252	8	.	.	PUNCT
bjp-15259	253	1	suhre	suhre	PROPN
bjp-15259	253	2	k	k	PROPN
bjp-15259	253	3	,	,	PUNCT
bjp-15259	253	4	sanejouand	sanejouand	PROPN
bjp-15259	253	5	yh	yh	PROPN
bjp-15259	253	6	.	.	PROPN
bjp-15259	253	7	elne´mo	elne´mo	PROPN
bjp-15259	253	8	:	:	PUNCT
bjp-15259	253	9	a	a	DET
bjp-15259	253	10	normal	normal	ADJ
bjp-15259	253	11	mode	mode	NOUN
bjp-15259	253	12	webserver	webserver	NOUN
bjp-15259	253	13	for	for	ADP
bjp-15259	253	14	protein	protein	NOUN
bjp-15259	253	15	movement	movement	NOUN
bjp-15259	253	16	analysis	analysis	NOUN
bjp-15259	253	17	and	and	CCONJ
bjp-15259	253	18	the	the	DET
bjp-15259	253	19	generation	generation	NOUN
bjp-15259	253	20	of	of	ADP
bjp-15259	253	21	templates	template	NOUN
bjp-15259	253	22	for	for	ADP
bjp-15259	253	23	molecular	molecular	ADJ
bjp-15259	253	24	replacement	replacement	NOUN
bjp-15259	253	25	.	.	PUNCT
bjp-15259	254	1	nucleic	nucleic	ADJ
bjp-15259	254	2	acids	acid	NOUN
bjp-15259	254	3	res	re	NOUN
bjp-15259	254	4	.	.	PUNCT
bjp-15259	254	5	2004	2004	NUM
bjp-15259	254	6	;	;	PUNCT
bjp-15259	254	7	32	32	NUM
bjp-15259	254	8	:	:	PUNCT
bjp-15259	254	9	610	610	NUM
bjp-15259	254	10	-	-	SYM
bjp-15259	254	11	14	14	NUM
bjp-15259	254	12	.	.	PUNCT
bjp-15259	255	1	tina	tina	PROPN
bjp-15259	255	2	kg	kg	PROPN
bjp-15259	255	3	,	,	PUNCT
bjp-15259	255	4	bhadra	bhadra	PROPN
bjp-15259	255	5	r	r	PROPN
bjp-15259	255	6	,	,	PUNCT
bjp-15259	255	7	srinivasan	srinivasan	PROPN
bjp-15259	255	8	n.	n.	PROPN
bjp-15259	255	9	pic	pic	PROPN
bjp-15259	255	10	:	:	PUNCT
bjp-15259	255	11	protein	protein	NOUN
bjp-15259	255	12	interactions	interaction	NOUN
bjp-15259	255	13	calculator	calculator	NOUN
bjp-15259	255	14	.	.	PUNCT
bjp-15259	256	1	nucleic	nucleic	ADJ
bjp-15259	256	2	acids	acid	NOUN
bjp-15259	256	3	res	re	NOUN
bjp-15259	256	4	.	.	PUNCT
bjp-15259	256	5	2007	2007	NUM
bjp-15259	256	6	;	;	PUNCT
bjp-15259	256	7	35	35	NUM
bjp-15259	256	8	:	:	PUNCT
bjp-15259	256	9	473	473	NUM
bjp-15259	256	10	-	-	SYM
bjp-15259	256	11	76	76	NUM
bjp-15259	256	12	.	.	PUNCT
bjp-15259	257	1	tovchigrechko	tovchigrechko	PROPN
bjp-15259	257	2	a	a	PRON
bjp-15259	257	3	,	,	PUNCT
bjp-15259	257	4	vakser	vakser	PROPN
bjp-15259	257	5	ia	ia	PROPN
bjp-15259	257	6	.	.	PUNCT
bjp-15259	258	1	gramm	gramm	PROPN
bjp-15259	258	2	-	-	PUNCT
bjp-15259	258	3	x	x	PROPN
bjp-15259	258	4	public	public	ADJ
bjp-15259	258	5	web	web	NOUN
bjp-15259	258	6	server	server	NOUN
bjp-15259	258	7	for	for	ADP
bjp-15259	258	8	protein	protein	NOUN
bjp-15259	258	9	-	-	PUNCT
bjp-15259	258	10	protein	protein	NOUN
bjp-15259	258	11	docking	docking	NOUN
bjp-15259	258	12	.	.	PUNCT
bjp-15259	259	1	nucleic	nucleic	ADJ
bjp-15259	259	2	acids	acid	NOUN
bjp-15259	259	3	res	re	NOUN
bjp-15259	259	4	.	.	PUNCT
bjp-15259	259	5	2006	2006	NUM
bjp-15259	259	6	;	;	PUNCT
bjp-15259	259	7	34	34	NUM
bjp-15259	259	8	:	:	PUNCT
bjp-15259	259	9	310	310	NUM
bjp-15259	259	10	-	-	SYM
bjp-15259	259	11	14	14	NUM
bjp-15259	259	12	.	.	PUNCT
bjp-15259	260	1	vande	vande	PROPN
bjp-15259	260	2	velde	velde	PROPN
bjp-15259	260	3	c	c	PROPN
bjp-15259	260	4	,	,	PUNCT
bjp-15259	260	5	dion	dion	PROPN
bjp-15259	260	6	pa	pa	PROPN
bjp-15259	260	7	,	,	PUNCT
bjp-15259	260	8	rouleau	rouleau	PROPN
bjp-15259	260	9	ga	ga	PROPN
bjp-15259	260	10	.	.	PROPN
bjp-15259	260	11	amyotrophic	amyotrophic	PROPN
bjp-15259	260	12	lateral	lateral	ADJ
bjp-15259	260	13	sclerosis	sclerosis	NOUN
bjp-15259	260	14	:	:	PUNCT
bjp-15259	260	15	new	new	ADJ
bjp-15259	260	16	genes	gene	NOUN
bjp-15259	260	17	,	,	PUNCT
bjp-15259	260	18	new	new	ADJ
bjp-15259	260	19	models	model	NOUN
bjp-15259	260	20	,	,	PUNCT
bjp-15259	260	21	and	and	CCONJ
bjp-15259	260	22	new	new	ADJ
bjp-15259	260	23	mechanisms	mechanism	NOUN
bjp-15259	260	24	.	.	PUNCT
bjp-15259	261	1	f1000	f1000	PROPN
bjp-15259	261	2	biol	biol	PROPN
bjp-15259	261	3	rep	rep	PROPN
bjp-15259	261	4	.	.	PROPN
bjp-15259	261	5	2011	2011	NUM
bjp-15259	261	6	;	;	PUNCT
bjp-15259	261	7	3	3	NUM
bjp-15259	261	8	:	:	SYM
bjp-15259	261	9	18	18	NUM
bjp-15259	261	10	.	.	X
bjp-15259	261	11	varfolomeev	varfolomeev	PROPN
bjp-15259	261	12	sd	sd	PROPN
bjp-15259	261	13	,	,	PUNCT
bjp-15259	261	14	uporov	uporov	ADJ
bjp-15259	261	15	iv	iv	NUM
bjp-15259	261	16	,	,	PUNCT
bjp-15259	261	17	fedorov	fedorov	PROPN
bjp-15259	261	18	ev	ev	PROPN
bjp-15259	261	19	.	.	PROPN
bjp-15259	261	20	bioinformatics	bioinformatic	NOUN
bjp-15259	261	21	and	and	CCONJ
bjp-15259	261	22	molecular	molecular	ADJ
bjp-15259	261	23	modeling	modeling	NOUN
bjp-15259	261	24	in	in	ADP
bjp-15259	261	25	chemical	chemical	ADJ
bjp-15259	261	26	enzymology	enzymology	NOUN
bjp-15259	261	27	:	:	PUNCT
bjp-15259	261	28	active	active	ADJ
bjp-15259	261	29	sites	site	NOUN
bjp-15259	261	30	of	of	ADP
bjp-15259	261	31	hydrolases	hydrolase	NOUN
bjp-15259	261	32	.	.	PUNCT
bjp-15259	262	1	biochemistry	biochemistry	NOUN
bjp-15259	262	2	(	(	PUNCT
bjp-15259	262	3	mosc	mosc	PROPN
bjp-15259	262	4	)	)	PUNCT
bjp-15259	262	5	.	.	PUNCT
bjp-15259	263	1	2002	2002	NUM
bjp-15259	263	2	;	;	PUNCT
bjp-15259	263	3	67	67	NUM
bjp-15259	263	4	:	:	SYM
bjp-15259	263	5	1099	1099	NUM
bjp-15259	263	6	-	-	SYM
bjp-15259	263	7	108	108	NUM
bjp-15259	263	8	.	.	PUNCT
bjp-15259	264	1	wu	wu	PROPN
bjp-15259	264	2	d	d	PROPN
bjp-15259	264	3	,	,	PUNCT
bjp-15259	264	4	yu	yu	PROPN
bjp-15259	264	5	w	w	PROPN
bjp-15259	264	6	,	,	PUNCT
bjp-15259	264	7	kishikawa	kishikawa	PROPN
bjp-15259	264	8	h	h	PROPN
bjp-15259	264	9	,	,	PUNCT
bjp-15259	264	10	folkerth	folkerth	PROPN
bjp-15259	264	11	rd	rd	PROPN
bjp-15259	264	12	,	,	PUNCT
bjp-15259	264	13	iafrate	iafrate	PROPN
bjp-15259	264	14	aj	aj	PROPN
bjp-15259	264	15	,	,	PUNCT
bjp-15259	264	16	shen	shen	PROPN
bjp-15259	264	17	y	y	PROPN
bjp-15259	264	18	,	,	PUNCT
bjp-15259	264	19	xin	xin	PROPN
bjp-15259	264	20	w	w	PROPN
bjp-15259	264	21	,	,	PUNCT
bjp-15259	264	22	sims	sim	NOUN
bjp-15259	264	23	k	k	PROPN
bjp-15259	264	24	,	,	PUNCT
bjp-15259	264	25	hu	hu	PROPN
bjp-15259	264	26	gf	gf	PROPN
bjp-15259	264	27	.	.	PUNCT
bjp-15259	264	28	angiogenin	angiogenin	PROPN
bjp-15259	264	29	loss	loss	PROPN
bjp-15259	264	30	-	-	PUNCT
bjp-15259	264	31	of	of	ADP
bjp-15259	264	32	-	-	PUNCT
bjp-15259	264	33	function	function	NOUN
bjp-15259	264	34	mutations	mutation	NOUN
bjp-15259	264	35	in	in	ADP
bjp-15259	264	36	amyotrophic	amyotrophic	ADJ
bjp-15259	264	37	lateral	lateral	ADJ
bjp-15259	264	38	sclerosis	sclerosis	NOUN
bjp-15259	264	39	.	.	PUNCT
bjp-15259	265	1	ann	ann	PROPN
bjp-15259	265	2	neurol	neurol	PROPN
bjp-15259	265	3	.	.	PUNCT
bjp-15259	266	1	2007	2007	NUM
bjp-15259	266	2	;	;	PUNCT
bjp-15259	266	3	62	62	NUM
bjp-15259	266	4	:	:	PUNCT
bjp-15259	266	5	609	609	NUM
bjp-15259	266	6	-	-	SYM
bjp-15259	266	7	17	17	NUM
bjp-15259	266	8	.	.	PUNCT
bjp-15259	267	1	yip	yip	PROPN
bjp-15259	267	2	yl	yl	PROPN
bjp-15259	267	3	,	,	PUNCT
bjp-15259	267	4	famiglietti	famiglietti	PROPN
bjp-15259	267	5	m	m	PROPN
bjp-15259	267	6	,	,	PUNCT
bjp-15259	267	7	gos	gos	PROPN
bjp-15259	267	8	a	a	PRON
bjp-15259	267	9	,	,	PUNCT
bjp-15259	267	10	duek	duek	PROPN
bjp-15259	267	11	pd	pd	PROPN
bjp-15259	267	12	,	,	PUNCT
bjp-15259	267	13	david	david	PROPN
bjp-15259	267	14	fp	fp	PROPN
bjp-15259	267	15	,	,	PUNCT
bjp-15259	267	16	gateau	gateau	PROPN
bjp-15259	267	17	a	a	PROPN
bjp-15259	267	18	,	,	PUNCT
bjp-15259	267	19	bairoch	bairoch	NOUN
bjp-15259	267	20	a.	a.	NOUN
bjp-15259	267	21	annotating	annotate	VERB
bjp-15259	267	22	single	single	ADJ
bjp-15259	267	23	amino	amino	NOUN
bjp-15259	267	24	acid	acid	NOUN
bjp-15259	267	25	polymorphisms	polymorphism	NOUN
bjp-15259	267	26	in	in	ADP
bjp-15259	267	27	the	the	DET
bjp-15259	267	28	uniprot	uniprot	ADJ
bjp-15259	267	29	/	/	SYM
bjp-15259	267	30	swiss	swiss	ADJ
bjp-15259	267	31	-	-	PUNCT
bjp-15259	267	32	prot	prot	NOUN
bjp-15259	267	33	knowledge	knowledge	NOUN
bjp-15259	267	34	base	base	NOUN
bjp-15259	267	35	.	.	PUNCT
bjp-15259	268	1	hum	hum	PROPN
bjp-15259	268	2	mutat	mutat	PROPN
bjp-15259	268	3	.	.	PROPN
bjp-15259	268	4	2008	2008	NUM
bjp-15259	268	5	;	;	PUNCT
bjp-15259	268	6	29	29	NUM
bjp-15259	268	7	:	:	PUNCT
bjp-15259	268	8	361	361	NUM
bjp-15259	268	9	-	-	SYM
bjp-15259	268	10	66	66	NUM
bjp-15259	268	11	.	.	PUNCT
bjp-15259	269	1	yip	yip	PROPN
bjp-15259	269	2	yl	yl	PROPN
bjp-15259	269	3	,	,	PUNCT
bjp-15259	269	4	scheib	scheib	PROPN
bjp-15259	269	5	h	h	PROPN
bjp-15259	269	6	,	,	PUNCT
bjp-15259	269	7	diemand	diemand	NOUN
bjp-15259	269	8	av	av	NOUN
bjp-15259	269	9	,	,	PUNCT
bjp-15259	269	10	gattiker	gattiker	PROPN
bjp-15259	269	11	a	a	NOUN
bjp-15259	269	12	,	,	PUNCT
bjp-15259	269	13	famiglietti	famiglietti	PROPN
bjp-15259	269	14	lm	lm	PROPN
bjp-15259	269	15	,	,	PUNCT
bjp-15259	269	16	gasteiger	gasteiger	NOUN
bjp-15259	269	17	e	e	NOUN
bjp-15259	269	18	,	,	PUNCT
bjp-15259	269	19	bairoch	bairoch	NOUN
bjp-15259	269	20	a.	a.	NOUN
bjp-15259	269	21	the	the	DET
bjp-15259	269	22	swiss	swiss	ADJ
bjp-15259	269	23	-	-	PUNCT
bjp-15259	269	24	prot	prot	NOUN
bjp-15259	269	25	variant	variant	NOUN
bjp-15259	269	26	page	page	NOUN
bjp-15259	269	27	and	and	CCONJ
bjp-15259	269	28	the	the	DET
bjp-15259	269	29	modsnp	modsnp	NOUN
bjp-15259	269	30	database	database	NOUN
bjp-15259	269	31	:	:	PUNCT
bjp-15259	269	32	a	a	DET
bjp-15259	269	33	resource	resource	NOUN
bjp-15259	269	34	for	for	ADP
bjp-15259	269	35	sequence	sequence	NOUN
bjp-15259	269	36	and	and	CCONJ
bjp-15259	269	37	structure	structure	NOUN
bjp-15259	269	38	information	information	NOUN
bjp-15259	269	39	on	on	ADP
bjp-15259	269	40	human	human	ADJ
bjp-15259	269	41	protein	protein	NOUN
bjp-15259	269	42	variants	variant	NOUN
bjp-15259	269	43	.	.	PUNCT
bjp-15259	270	1	hum	hum	PROPN
bjp-15259	270	2	mutat	mutat	PROPN
bjp-15259	270	3	.	.	PUNCT
bjp-15259	270	4	2004	2004	NUM
bjp-15259	270	5	;	;	PUNCT
bjp-15259	270	6	23	23	NUM
bjp-15259	270	7	:	:	PUNCT
bjp-15259	270	8	464	464	NUM
bjp-15259	270	9	-	-	SYM
bjp-15259	270	10	70	70	NUM
bjp-15259	270	11	.	.	PUNCT
bjp-15259	271	1	yuan	yuan	PROPN
bjp-15259	271	2	z	z	PROPN
bjp-15259	271	3	,	,	PUNCT
bjp-15259	271	4	bailey	bailey	PROPN
bjp-15259	271	5	tl	tl	PROPN
bjp-15259	271	6	,	,	PUNCT
bjp-15259	271	7	teasdale	teasdale	PROPN
bjp-15259	271	8	rd	rd	PROPN
bjp-15259	271	9	.	.	PROPN
bjp-15259	271	10	prediction	prediction	NOUN
bjp-15259	271	11	of	of	ADP
bjp-15259	271	12	protein	protein	NOUN
bjp-15259	271	13	b	b	NOUN
bjp-15259	271	14	-	-	PUNCT
bjp-15259	271	15	factor	factor	NOUN
bjp-15259	271	16	profiles	profile	NOUN
bjp-15259	271	17	.	.	PUNCT
bjp-15259	272	1	proteins	protein	NOUN
bjp-15259	272	2	2005	2005	NUM
bjp-15259	272	3	;	;	PUNCT
bjp-15259	272	4	58	58	NUM
bjp-15259	272	5	:	:	PUNCT
bjp-15259	272	6	905	905	NUM
bjp-15259	272	7	-	-	SYM
bjp-15259	272	8	12	12	NUM
bjp-15259	272	9	.	.	PUNCT
bjp-15259	273	1	author	author	NOUN
bjp-15259	273	2	info	info	NOUN
bjp-15259	273	3	ramalingar	ramalingar	NOUN
bjp-15259	273	4	rajasekaran	rajasekaran	NOUN
bjp-15259	273	5	(	(	PUNCT
bjp-15259	273	6	principal	principal	ADJ
bjp-15259	273	7	contact	contact	NOUN
bjp-15259	273	8	)	)	PUNCT
bjp-15259	274	1	e	e	NOUN
bjp-15259	274	2	-	-	NOUN
bjp-15259	274	3	mail	mail	NOUN
bjp-15259	274	4	:	:	PUNCT
bjp-15259	274	5	rrajasekaran@vit.ac.in	rrajasekaran@vit.ac.in	PROPN
bjp-15259	274	6	bangladesh	bangladesh	PROPN
bjp-15259	274	7	j	j	PROPN
bjp-15259	274	8	pharmacol	pharmacol	PROPN
bjp-15259	274	9	2013	2013	NUM
bjp-15259	274	10	;	;	PUNCT
bjp-15259	274	11	8	8	NUM
bjp-15259	274	12	:	:	PUNCT
bjp-15259	274	13	382	382	NUM
bjp-15259	274	14	-	-	SYM
bjp-15259	274	15	389	389	NUM
bjp-15259	274	16	389	389	NUM
bjp-15259	274	17	dateprinted	dateprinte	VERB
bjp-15259	274	18	:	:	PUNCT
bjp-15259	274	19	this	this	DET
bjp-15259	274	20	article	article	NOUN
bjp-15259	274	21	was	be	AUX
bjp-15259	274	22	downloaded	download	VERB
bjp-15259	274	23	by	by	ADP
bjp-15259	274	24	you	you	PRON
bjp-15259	274	25	on	on	ADP
bjp-15259	274	26	:	:	PUNCT
bjp-15259	274	27	aug	aug	PROPN
bjp-15259	274	28	29	29	NUM
bjp-15259	274	29	,	,	PUNCT
bjp-15259	274	30	2018	2018	NUM