id	sid	tid	token	lemma	pos
bjp-18180	1	1	bangladesh	bangladesh	PROPN
bjp-18180	1	2	journal	journal	PROPN
bjp-18180	1	3	of	of	ADP
bjp-18180	1	4	pharmacology	pharmacology	NOUN
bjp-18180	1	5	research	research	NOUN
bjp-18180	1	6	article	article	NOUN
bjp-18180	1	7	design	design	NOUN
bjp-18180	1	8	and	and	CCONJ
bjp-18180	1	9	docking	docking	NOUN
bjp-18180	1	10	of	of	ADP
bjp-18180	1	11	novel	novel	ADJ
bjp-18180	1	12	series	series	NOUN
bjp-18180	1	13	of	of	ADP
bjp-18180	1	14	hybrid	hybrid	ADJ
bjp-18180	1	15	xanthones	xanthone	NOUN
bjp-18180	1	16	as	as	ADP
bjp-18180	1	17	anti	anti	ADJ
bjp-18180	1	18	-	-	ADJ
bjp-18180	1	19	cancer	cancer	ADJ
bjp-18180	1	20	agent	agent	NOUN
bjp-18180	1	21	to	to	PART
bjp-18180	1	22	target	target	VERB
bjp-18180	1	23	human	human	ADJ
bjp-18180	1	24	dna	dna	NOUN
bjp-18180	1	25	topoisomerase	topoisomerase	NOUN
bjp-18180	1	26	2	2	NUM
bjp-18180	1	27	-	-	PUNCT
bjp-18180	1	28	alpha	alpha	NOUN
bjp-18180	1	29	bjp	bjp	NOUN
bjp-18180	1	30	binding	bind	VERB
bjp-18180	1	31	pocket	pocket	NOUN
bjp-18180	1	32	introduction	introduction	NOUN
bjp-18180	1	33	enzymes	enzyme	NOUN
bjp-18180	1	34	that	that	PRON
bjp-18180	1	35	catalyze	catalyze	VERB
bjp-18180	1	36	topological	topological	ADJ
bjp-18180	1	37	alterations	alteration	NOUN
bjp-18180	1	38	of	of	ADP
bjp-18180	1	39	dna	dna	PROPN
bjp-18180	1	40	are	be	AUX
bjp-18180	1	41	called	call	VERB
bjp-18180	1	42	topoisomerase	topoisomerase	NOUN
bjp-18180	1	43	.	.	PUNCT
bjp-18180	2	1	topoisomerase	topoisomerase	NOUN
bjp-18180	2	2	can	can	AUX
bjp-18180	2	3	relax	relax	VERB
bjp-18180	2	4	or	or	CCONJ
bjp-18180	2	5	add	add	VERB
bjp-18180	2	6	supercoiling	supercoiling	NOUN
bjp-18180	2	7	and	and	CCONJ
bjp-18180	2	8	is	be	AUX
bjp-18180	2	9	in	in	ADP
bjp-18180	2	10	thetop	thetop	NOUN
bjp-18180	2	11	of	of	ADP
bjp-18180	2	12	hits	hit	NOUN
bjp-18180	2	13	for	for	ADP
bjp-18180	2	14	anti	anti	ADJ
bjp-18180	2	15	-	-	ADJ
bjp-18180	2	16	cancer	cancer	ADJ
bjp-18180	2	17	drugs	drug	NOUN
bjp-18180	2	18	.	.	PUNCT
bjp-18180	3	1	dna	dna	NOUN
bjp-18180	3	2	-	-	PUNCT
bjp-18180	3	3	intercalating	intercalate	VERB
bjp-18180	3	4	agents	agent	NOUN
bjp-18180	3	5	have	have	VERB
bjp-18180	3	6	the	the	DET
bjp-18180	3	7	ability	ability	NOUN
bjp-18180	3	8	to	to	PART
bjp-18180	3	9	cause	cause	VERB
bjp-18180	3	10	lethal	lethal	ADJ
bjp-18180	3	11	dna	dna	NOUN
bjp-18180	3	12	double	double	ADJ
bjp-18180	3	13	-	-	PUNCT
bjp-18180	3	14	strand	strand	NOUN
bjp-18180	3	15	breaks	break	NOUN
bjp-18180	3	16	,	,	PUNCT
bjp-18180	3	17	by	by	ADP
bjp-18180	3	18	hindering	hinder	VERB
bjp-18180	3	19	normal	normal	ADJ
bjp-18180	3	20	functioning	functioning	NOUN
bjp-18180	3	21	of	of	ADP
bjp-18180	3	22	topoisomerase	topoisomerase	PROPN
bjp-18180	3	23	ii	ii	PROPN
bjp-18180	3	24	.	.	PUNCT
bjp-18180	4	1	topoisomerase	topoisomerase	PROPN
bjp-18180	4	2	ii	ii	PROPN
bjp-18180	4	3	requires	require	VERB
bjp-18180	4	4	mg	mg	PROPN
bjp-18180	4	5	(	(	PUNCT
bjp-18180	4	6	ii	ii	PROPN
bjp-18180	4	7	)	)	PUNCT
bjp-18180	4	8	and	and	CCONJ
bjp-18180	4	9	atp	atp	NOUN
bjp-18180	4	10	hydrolysis	hydrolysis	NOUN
bjp-18180	4	11	for	for	ADP
bjp-18180	4	12	enzyme	enzyme	NOUN
bjp-18180	4	13	turn	turn	NOUN
bjp-18180	4	14	over	over	ADP
bjp-18180	4	15	and	and	CCONJ
bjp-18180	4	16	rapid	rapid	ADJ
bjp-18180	4	17	kinetics	kinetic	NOUN
bjp-18180	4	18	(	(	PUNCT
bjp-18180	4	19	champoux	champoux	NOUN
bjp-18180	4	20	,	,	PUNCT
bjp-18180	4	21	2001	2001	NUM
bjp-18180	4	22	)	)	PUNCT
bjp-18180	4	23	.	.	PUNCT
bjp-18180	5	1	human	human	PROPN
bjp-18180	5	2	topoisomerases	topoisomerases	PROPN
bjp-18180	5	3	ii	ii	PROPN
bjp-18180	5	4	are	be	AUX
bjp-18180	5	5	of	of	ADP
bjp-18180	5	6	two	two	NUM
bjp-18180	5	7	types	type	NOUN
bjp-18180	5	8	(	(	PUNCT
bjp-18180	5	9	i	i	NOUN
bjp-18180	5	10	)	)	PUNCT
bjp-18180	5	11	topoisomerase	topoisomerase	PROPN
bjp-18180	5	12	ii	ii	PROPN
bjp-18180	5	13	,	,	PUNCT
bjp-18180	5	14	(	(	PUNCT
bjp-18180	5	15	ii	ii	NOUN
bjp-18180	5	16	)	)	PUNCT
bjp-18180	5	17	topoisomerase	topoisomerase	NOUN
bjp-18180	5	18	ii	ii	NOUN
bjp-18180	5	19	.	.	PUNCT
bjp-18180	6	1	topoisomerase	topoisomerase	PROPN
bjp-18180	6	2	ii	ii	PROPN
bjp-18180	6	3	has	have	VERB
bjp-18180	6	4	two	two	NUM
bjp-18180	6	5	distinct	distinct	ADJ
bjp-18180	6	6	dna	dna	ADJ
bjp-18180	6	7	-	-	PUNCT
bjp-18180	6	8	independent	independent	ADJ
bjp-18180	6	9	binding	binding	ADJ
bjp-18180	6	10	pockets	pocket	NOUN
bjp-18180	6	11	,	,	PUNCT
bjp-18180	6	12	one	one	NUM
bjp-18180	6	13	within	within	ADP
bjp-18180	6	14	the	the	DET
bjp-18180	6	15	catalytic	catalytic	ADJ
bjp-18180	6	16	domain	domain	NOUN
bjp-18180	6	17	and	and	CCONJ
bjp-18180	6	18	second	second	ADJ
bjp-18180	6	19	within	within	ADP
bjp-18180	6	20	the	the	DET
bjp-18180	6	21	n	n	CCONJ
bjp-18180	6	22	-	-	PUNCT
bjp-18180	6	23	terminal	terminal	ADJ
bjp-18180	6	24	atp	atp	NOUN
bjp-18180	6	25	-	-	PUNCT
bjp-18180	6	26	binding	bind	VERB
bjp-18180	6	27	domain	domain	NOUN
bjp-18180	6	28	(	(	PUNCT
bjp-18180	6	29	vilain	vilain	NOUN
bjp-18180	6	30	et	et	PROPN
bjp-18180	6	31	al	al	PROPN
bjp-18180	6	32	.	.	PROPN
bjp-18180	6	33	,	,	PUNCT
bjp-18180	6	34	2003	2003	NUM
bjp-18180	6	35	)	)	PUNCT
bjp-18180	6	36	.	.	PUNCT
bjp-18180	7	1	topo	topo	PROPN
bjp-18180	7	2	ii	ii	PROPN
bjp-18180	7	3	plays	play	VERB
bjp-18180	7	4	a	a	DET
bjp-18180	7	5	key	key	ADJ
bjp-18180	7	6	role	role	NOUN
bjp-18180	7	7	in	in	ADP
bjp-18180	7	8	dna	dna	PROPN
bjp-18180	7	9	replication	replication	NOUN
bjp-18180	7	10	with	with	ADP
bjp-18180	7	11	main	main	ADJ
bjp-18180	7	12	functions	function	NOUN
bjp-18180	7	13	are	be	AUX
bjp-18180	7	14	chromosome	chromosome	NOUN
bjp-18180	7	15	segregation	segregation	NOUN
bjp-18180	7	16	,	,	PUNCT
bjp-18180	7	17	chromosome	chromosome	NOUN
bjp-18180	7	18	condensation	condensation	NOUN
bjp-18180	7	19	,	,	PUNCT
bjp-18180	7	20	arrest	arrest	NOUN
bjp-18180	7	21	in	in	ADP
bjp-18180	7	22	meiosis	meiosis	NOUN
bjp-18180	7	23	i	i	PRON
bjp-18180	7	24	and	and	CCONJ
bjp-18180	7	25	recombination	recombination	NOUN
bjp-18180	7	26	suppression	suppression	NOUN
bjp-18180	7	27	(	(	PUNCT
bjp-18180	7	28	watt	watt	NOUN
bjp-18180	7	29	and	and	CCONJ
bjp-18180	7	30	hickson	hickson	PROPN
bjp-18180	7	31	,	,	PUNCT
bjp-18180	7	32	1994	1994	NUM
bjp-18180	7	33	)	)	PUNCT
bjp-18180	7	34	.	.	PUNCT
bjp-18180	8	1	in	in	ADP
bjp-18180	8	2	cancer	cancer	NOUN
bjp-18180	8	3	cells	cell	NOUN
bjp-18180	8	4	,	,	PUNCT
bjp-18180	8	5	topo	topo	PROPN
bjp-18180	8	6	ii	ii	PROPN
bjp-18180	8	7	concentrations	concentration	NOUN
bjp-18180	8	8	are	be	AUX
bjp-18180	8	9	dramatically	dramatically	ADV
bjp-18180	8	10	up	up	ADV
bjp-18180	8	11	-	-	PUNCT
bjp-18180	8	12	regulated	regulate	VERB
bjp-18180	8	13	because	because	SCONJ
bjp-18180	8	14	of	of	ADP
bjp-18180	8	15	rapid	rapid	ADJ
bjp-18180	8	16	cell	cell	NOUN
bjp-18180	8	17	division	division	NOUN
bjp-18180	8	18	and	and	CCONJ
bjp-18180	8	19	cell	cell	NOUN
bjp-18180	8	20	growth	growth	NOUN
bjp-18180	8	21	(	(	PUNCT
bjp-18180	8	22	heck	heck	NOUN
bjp-18180	8	23	and	and	CCONJ
bjp-18180	8	24	earnshaw	earnshaw	PROPN
bjp-18180	8	25	,	,	PUNCT
bjp-18180	8	26	1986	1986	NUM
bjp-18180	8	27	;	;	PUNCT
bjp-18180	8	28	woessner	woessner	PROPN
bjp-18180	8	29	et	et	PROPN
bjp-18180	8	30	al	al	PROPN
bjp-18180	8	31	.	.	PROPN
bjp-18180	8	32	,	,	PUNCT
bjp-18180	8	33	1991	1991	NUM
bjp-18180	8	34	)	)	PUNCT
bjp-18180	8	35	.	.	PUNCT
bjp-18180	9	1	therefore	therefore	ADV
bjp-18180	9	2	,	,	PUNCT
bjp-18180	9	3	numbers	number	NOUN
bjp-18180	9	4	of	of	ADP
bjp-18180	9	5	anti	anti	ADJ
bjp-18180	9	6	-	-	ADJ
bjp-18180	9	7	cancer	cancer	ADJ
bjp-18180	9	8	agents	agent	NOUN
bjp-18180	9	9	are	be	AUX
bjp-18180	9	10	designed	design	VERB
bjp-18180	9	11	with	with	ADP
bjp-18180	9	12	topo	topo	PROPN
bjp-18180	9	13	ii	ii	PROPN
bjp-18180	9	14	as	as	ADP
bjp-18180	9	15	a	a	DET
bjp-18180	9	16	potential	potential	ADJ
bjp-18180	9	17	target	target	NOUN
bjp-18180	9	18	(	(	PUNCT
bjp-18180	9	19	wilstermann	wilstermann	NOUN
bjp-18180	9	20	and	and	CCONJ
bjp-18180	9	21	osheroff	osheroff	NOUN
bjp-18180	9	22	,	,	PUNCT
bjp-18180	9	23	2003	2003	NUM
bjp-18180	9	24	;	;	PUNCT
bjp-18180	9	25	fortune	fortune	NOUN
bjp-18180	9	26	et	et	PROPN
bjp-18180	9	27	al	al	PROPN
bjp-18180	9	28	.	.	PROPN
bjp-18180	9	29	,	,	PUNCT
bjp-18180	9	30	2000	2000	NUM
bjp-18180	9	31	)	)	PUNCT
bjp-18180	9	32	.	.	PUNCT
bjp-18180	10	1	the	the	DET
bjp-18180	10	2	primary	primary	ADJ
bjp-18180	10	3	mode	mode	NOUN
bjp-18180	10	4	of	of	ADP
bjp-18180	10	5	cytotoxicity	cytotoxicity	NOUN
bjp-18180	10	6	of	of	ADP
bjp-18180	10	7	most	most	ADJ
bjp-18180	10	8	dna	dna	PROPN
bjp-18180	10	9	intercalating	intercalate	VERB
bjp-18180	10	10	agents	agent	NOUN
bjp-18180	10	11	involves	involve	VERB
bjp-18180	10	12	inhibition	inhibition	NOUN
bjp-18180	10	13	of	of	ADP
bjp-18180	10	14	religation	religation	NOUN
bjp-18180	10	15	step	step	NOUN
bjp-18180	10	16	of	of	ADP
bjp-18180	10	17	action	action	NOUN
bjp-18180	10	18	of	of	ADP
bjp-18180	10	19	the	the	DET
bjp-18180	10	20	enzyme	enzyme	NOUN
bjp-18180	10	21	dna	dna	PROPN
bjp-18180	10	22	topo	topo	PROPN
bjp-18180	10	23	ii	ii	PROPN
bjp-18180	10	24	(	(	PUNCT
bjp-18180	10	25	liu	liu	PROPN
bjp-18180	10	26	,	,	PUNCT
bjp-18180	10	27	1989	1989	NUM
bjp-18180	10	28	;	;	PUNCT
bjp-18180	10	29	robinson	robinson	PROPN
bjp-18180	10	30	and	and	CCONJ
bjp-18180	10	31	osheroff	osheroff	NOUN
bjp-18180	10	32	,	,	PUNCT
bjp-18180	10	33	1991	1991	NUM
bjp-18180	10	34	)	)	PUNCT
bjp-18180	10	35	.	.	PUNCT
bjp-18180	11	1	xanthonescan	xanthonescan	PROPN
bjp-18180	11	2	also	also	ADV
bjp-18180	11	3	binds	bind	VERB
bjp-18180	11	4	and	and	CCONJ
bjp-18180	11	5	shows	show	VERB
bjp-18180	11	6	anti	anti	ADJ
bjp-18180	11	7	-	-	ADJ
bjp-18180	11	8	cancer	cancer	ADJ
bjp-18180	11	9	activity	activity	NOUN
bjp-18180	11	10	by	by	ADP
bjp-18180	11	11	forming	form	VERB
bjp-18180	11	12	a	a	DET
bjp-18180	11	13	stable	stable	ADJ
bjp-18180	11	14	binding	bind	VERB
bjp-18180	11	15	complex	complex	NOUN
bjp-18180	11	16	with	with	ADP
bjp-18180	11	17	n	n	CCONJ
bjp-18180	11	18	-	-	PUNCT
bjp-18180	11	19	terminal	terminal	ADJ
bjp-18180	11	20	atp	atp	NOUN
bjp-18180	11	21	-	-	PUNCT
bjp-18180	11	22	binding	bind	VERB
bjp-18180	11	23	domain	domain	NOUN
bjp-18180	11	24	of	of	ADP
bjp-18180	11	25	topo	topo	PROPN
bjp-18180	11	26	ii	ii	PROPN
bjp-18180	11	27	(	(	PUNCT
bjp-18180	11	28	jun	jun	PROPN
bjp-18180	11	29	et	et	PROPN
bjp-18180	11	30	al	al	PROPN
bjp-18180	11	31	.	.	PROPN
bjp-18180	11	32	,	,	PUNCT
bjp-18180	11	33	2011	2011	NUM
bjp-18180	11	34	)	)	PUNCT
bjp-18180	11	35	like	like	ADP
bjp-18180	11	36	novobiocin	novobiocin	NOUN
bjp-18180	11	37	(	(	PUNCT
bjp-18180	11	38	larsen	larsen	PROPN
bjp-18180	11	39	et	et	PROPN
bjp-18180	11	40	al	al	PROPN
bjp-18180	11	41	.	.	PROPN
bjp-18180	11	42	,	,	PUNCT
bjp-18180	11	43	2003	2003	NUM
bjp-18180	11	44	)	)	PUNCT
bjp-18180	11	45	,	,	PUNCT
bjp-18180	11	46	cyclothialidine	cyclothialidine	ADJ
bjp-18180	11	47	(	(	PUNCT
bjp-18180	11	48	boehm	boehm	PROPN
bjp-18180	11	49	et	et	PROPN
bjp-18180	11	50	al	al	PROPN
bjp-18180	11	51	.	.	PROPN
bjp-18180	11	52	,	,	PUNCT
bjp-18180	11	53	2000	2000	NUM
bjp-18180	11	54	)	)	PUNCT
bjp-18180	11	55	and	and	CCONJ
bjp-18180	11	56	salvicine	salvicine	NOUN
bjp-18180	11	57	(	(	PUNCT
bjp-18180	11	58	hu	hu	PROPN
bjp-18180	11	59	et	et	PROPN
bjp-18180	11	60	al	al	PROPN
bjp-18180	11	61	.	.	PROPN
bjp-18180	11	62	,	,	PUNCT
bjp-18180	11	63	2006	2006	NUM
bjp-18180	11	64	)	)	PUNCT
bjp-18180	11	65	.	.	PUNCT
bjp-18180	12	1	xanthone	xanthone	PROPN
bjp-18180	12	2	fights	fight	VERB
bjp-18180	12	3	competitively	competitively	ADV
bjp-18180	12	4	with	with	ADP
bjp-18180	12	5	atp	atp	PROPN
bjp-18180	12	6	to	to	PART
bjp-18180	12	7	binds	bind	VERB
bjp-18180	12	8	with	with	ADP
bjp-18180	12	9	the	the	DET
bjp-18180	12	10	atp	atp	NOUN
bjp-18180	12	11	binding	bind	VERB
bjp-18180	12	12	site	site	NOUN
bjp-18180	12	13	on	on	ADP
bjp-18180	12	14	topo	topo	PROPN
bjp-18180	12	15	ii	ii	PROPN
bjp-18180	12	16	and	and	CCONJ
bjp-18180	12	17	directly	directly	ADV
bjp-18180	12	18	hampers	hamper	VERB
bjp-18180	12	19	the	the	DET
bjp-18180	12	20	energy	energy	NOUN
bjp-18180	12	21	driven	drive	VERB
bjp-18180	12	22	rapid	rapid	ADJ
bjp-18180	12	23	kinetics	kinetic	NOUN
bjp-18180	12	24	which	which	PRON
bjp-18180	12	25	lead	lead	VERB
bjp-18180	12	26	to	to	ADP
bjp-18180	12	27	a	a	DET
bjp-18180	12	28	higher	high	ADJ
bjp-18180	12	29	topo	topo	PROPN
bjp-18180	12	30	ii	ii	PROPN
bjp-18180	12	31	catalytic	catalytic	ADJ
bjp-18180	12	32	inhibitory	inhibitory	ADJ
bjp-18180	12	33	activity	activity	NOUN
bjp-18180	12	34	.	.	PUNCT
bjp-18180	13	1	a	a	DET
bjp-18180	13	2	journal	journal	NOUN
bjp-18180	13	3	of	of	ADP
bjp-18180	13	4	the	the	DET
bjp-18180	13	5	bangladesh	bangladesh	NOUN
bjp-18180	13	6	pharmacological	pharmacological	ADJ
bjp-18180	13	7	society	society	NOUN
bjp-18180	13	8	(	(	PUNCT
bjp-18180	13	9	bdps	bdps	NOUN
bjp-18180	13	10	)	)	PUNCT
bjp-18180	13	11	bangladesh	bangladesh	PROPN
bjp-18180	13	12	j	j	PROPN
bjp-18180	13	13	pharmacol	pharmacol	PROPN
bjp-18180	13	14	2014	2014	NUM
bjp-18180	13	15	;	;	PUNCT
bjp-18180	13	16	9	9	NUM
bjp-18180	13	17	:	:	SYM
bjp-18180	13	18	208	208	NUM
bjp-18180	13	19	-	-	SYM
bjp-18180	13	20	217	217	NUM
bjp-18180	13	21	journal	journal	NOUN
bjp-18180	13	22	homepage	homepage	NOUN
bjp-18180	13	23	:	:	PUNCT
bjp-18180	13	24	www.banglajol.info	www.banglajol.info	PROPN
bjp-18180	13	25	abstracted	abstract	VERB
bjp-18180	13	26	/	/	SYM
bjp-18180	13	27	indexed	index	VERB
bjp-18180	13	28	in	in	ADP
bjp-18180	13	29	academic	academic	ADJ
bjp-18180	13	30	search	search	NOUN
bjp-18180	13	31	complete	complete	ADJ
bjp-18180	13	32	,	,	PUNCT
bjp-18180	13	33	agroforestry	agroforestry	NOUN
bjp-18180	13	34	abstracts	abstract	NOUN
bjp-18180	13	35	,	,	PUNCT
bjp-18180	13	36	asia	asia	PROPN
bjp-18180	13	37	journals	journal	NOUN
bjp-18180	13	38	online	online	ADV
bjp-18180	13	39	,	,	PUNCT
bjp-18180	13	40	bangladesh	bangladesh	NOUN
bjp-18180	13	41	journals	journal	NOUN
bjp-18180	13	42	online	online	ADV
bjp-18180	13	43	,	,	PUNCT
bjp-18180	13	44	biological	biological	ADJ
bjp-18180	13	45	abstracts	abstract	NOUN
bjp-18180	13	46	,	,	PUNCT
bjp-18180	13	47	biosis	biosis	NOUN
bjp-18180	13	48	previews	preview	NOUN
bjp-18180	13	49	,	,	PUNCT
bjp-18180	13	50	cab	cab	NOUN
bjp-18180	13	51	abstracts	abstract	NOUN
bjp-18180	13	52	,	,	PUNCT
bjp-18180	13	53	current	current	ADJ
bjp-18180	13	54	abstracts	abstract	NOUN
bjp-18180	13	55	,	,	PUNCT
bjp-18180	13	56	directory	directory	NOUN
bjp-18180	13	57	of	of	ADP
bjp-18180	13	58	open	open	ADJ
bjp-18180	13	59	access	access	NOUN
bjp-18180	13	60	journals	journal	NOUN
bjp-18180	13	61	,	,	PUNCT
bjp-18180	13	62	embase	embase	NOUN
bjp-18180	13	63	/	/	SYM
bjp-18180	13	64	excerpta	excerpta	NOUN
bjp-18180	13	65	medica	medica	NOUN
bjp-18180	13	66	,	,	PUNCT
bjp-18180	13	67	google	google	PROPN
bjp-18180	13	68	scholar	scholar	NOUN
bjp-18180	13	69	,	,	PUNCT
bjp-18180	13	70	hinari	hinari	X
bjp-18180	13	71	(	(	PUNCT
bjp-18180	13	72	who	who	PRON
bjp-18180	13	73	)	)	PUNCT
bjp-18180	13	74	,	,	PUNCT
bjp-18180	13	75	international	international	ADJ
bjp-18180	13	76	pharmaceutical	pharmaceutical	ADJ
bjp-18180	13	77	abstracts	abstract	NOUN
bjp-18180	13	78	,	,	PUNCT
bjp-18180	13	79	open	open	ADJ
bjp-18180	13	80	j	j	PROPN
bjp-18180	13	81	-	-	PUNCT
bjp-18180	13	82	gate	gate	NOUN
bjp-18180	13	83	,	,	PUNCT
bjp-18180	13	84	science	science	NOUN
bjp-18180	13	85	citation	citation	NOUN
bjp-18180	13	86	index	index	NOUN
bjp-18180	13	87	expanded	expand	VERB
bjp-18180	13	88	,	,	PUNCT
bjp-18180	13	89	scopus	scopus	NOUN
bjp-18180	13	90	and	and	CCONJ
bjp-18180	13	91	social	social	ADJ
bjp-18180	13	92	sciences	sciences	PROPN
bjp-18180	13	93	citation	citation	NOUN
bjp-18180	13	94	index	index	NOUN
bjp-18180	13	95	issn	issn	PROPN
bjp-18180	13	96	:	:	PUNCT
bjp-18180	13	97	1991	1991	NUM
bjp-18180	13	98	-	-	PUNCT
bjp-18180	13	99	0088	0088	NUM
bjp-18180	13	100	abstract	abstract	ADJ
bjp-18180	13	101	topoisomerase	topoisomerase	NOUN
bjp-18180	13	102	(	(	PUNCT
bjp-18180	13	103	topo	topo	PROPN
bjp-18180	13	104	)	)	PUNCT
bjp-18180	13	105	ii	ii	PROPN
bjp-18180	13	106	is	be	AUX
bjp-18180	13	107	a	a	DET
bjp-18180	13	108	homodimeric	homodimeric	ADJ
bjp-18180	13	109	protein	protein	NOUN
bjp-18180	13	110	catalyzes	catalyze	VERB
bjp-18180	13	111	topological	topological	ADJ
bjp-18180	13	112	vicissitudes	vicissitude	NOUN
bjp-18180	13	113	by	by	ADP
bjp-18180	13	114	adding	add	VERB
bjp-18180	13	115	or	or	CCONJ
bjp-18180	13	116	by	by	ADP
bjp-18180	13	117	soothing	soothe	VERB
bjp-18180	13	118	super	super	ADJ
bjp-18180	13	119	coiling	coiling	NOUN
bjp-18180	13	120	transpiration	transpiration	NOUN
bjp-18180	13	121	,	,	PUNCT
bjp-18180	13	122	occurs	occur	VERB
bjp-18180	13	123	in	in	ADP
bjp-18180	13	124	human	human	ADJ
bjp-18180	13	125	dna	dna	NOUN
bjp-18180	13	126	during	during	ADP
bjp-18180	13	127	dna	dna	PROPN
bjp-18180	13	128	replication	replication	NOUN
bjp-18180	13	129	as	as	ADP
bjp-18180	13	130	an	an	DET
bjp-18180	13	131	outcome	outcome	NOUN
bjp-18180	13	132	chromosome	chromosome	NOUN
bjp-18180	13	133	segregation	segregation	NOUN
bjp-18180	13	134	and	and	CCONJ
bjp-18180	13	135	condensation	condensation	NOUN
bjp-18180	13	136	occurs	occur	VERB
bjp-18180	13	137	during	during	ADP
bjp-18180	13	138	meiosis	meiosis	NOUN
bjp-18180	13	139	i	i	NOUN
bjp-18180	13	140	and	and	CCONJ
bjp-18180	13	141	recombination	recombination	NOUN
bjp-18180	13	142	.	.	PUNCT
bjp-18180	14	1	to	to	PART
bjp-18180	14	2	prevent	prevent	VERB
bjp-18180	14	3	the	the	DET
bjp-18180	14	4	cleavage	cleavage	NOUN
bjp-18180	14	5	and	and	CCONJ
bjp-18180	14	6	religation	religation	NOUN
bjp-18180	14	7	activity	activity	NOUN
bjp-18180	14	8	we	we	PRON
bjp-18180	14	9	administered	administer	VERB
bjp-18180	14	10	novel	novel	ADJ
bjp-18180	14	11	hybrid	hybrid	NOUN
bjp-18180	14	12	substituted	substitute	VERB
bjp-18180	14	13	xanthone	xanthone	PROPN
bjp-18180	14	14	series	series	NOUN
bjp-18180	14	15	of	of	ADP
bjp-18180	14	16	drugs	drug	NOUN
bjp-18180	14	17	.	.	PUNCT
bjp-18180	15	1	the	the	DET
bjp-18180	15	2	toxicity	toxicity	NOUN
bjp-18180	15	3	prediction	prediction	NOUN
bjp-18180	15	4	showed	show	VERB
bjp-18180	15	5	outstanding	outstanding	ADJ
bjp-18180	15	6	results	result	NOUN
bjp-18180	15	7	which	which	DET
bjp-18180	15	8	impetus	impetus	NOUN
bjp-18180	15	9	to	to	PART
bjp-18180	15	10	study	study	VERB
bjp-18180	15	11	its	its	PRON
bjp-18180	15	12	anti	anti	ADJ
bjp-18180	15	13	-	-	ADJ
bjp-18180	15	14	cancer	cancer	ADJ
bjp-18180	15	15	activities	activity	NOUN
bjp-18180	15	16	by	by	ADP
bjp-18180	15	17	targeting	target	VERB
bjp-18180	15	18	topoisomerase	topoisomerase	NOUN
bjp-18180	15	19	(	(	PUNCT
bjp-18180	15	20	topo	topo	PROPN
bjp-18180	15	21	)	)	PUNCT
bjp-18180	15	22	ii	ii	PROPN
bjp-18180	15	23	.	.	PUNCT
bjp-18180	16	1	we	we	PRON
bjp-18180	16	2	developed	develop	VERB
bjp-18180	16	3	the	the	DET
bjp-18180	16	4	homology	homology	NOUN
bjp-18180	16	5	model	model	NOUN
bjp-18180	16	6	of	of	ADP
bjp-18180	16	7	the	the	DET
bjp-18180	16	8	topoisomerase	topoisomerase	NOUN
bjp-18180	16	9	(	(	PUNCT
bjp-18180	16	10	topo	topo	PROPN
bjp-18180	16	11	)	)	PUNCT
bjp-18180	16	12	ii	ii	PROPN
bjp-18180	16	13	due	due	ADP
bjp-18180	16	14	to	to	ADP
bjp-18180	16	15	the	the	DET
bjp-18180	16	16	unavailability	unavailability	NOUN
bjp-18180	16	17	of	of	ADP
bjp-18180	16	18	3d	3d	NUM
bjp-18180	16	19	structure	structure	NOUN
bjp-18180	16	20	in	in	ADP
bjp-18180	16	21	the	the	DET
bjp-18180	16	22	protein	protein	NOUN
bjp-18180	16	23	data	datum	NOUN
bjp-18180	16	24	bank	bank	PROPN
bjp-18180	16	25	.	.	PUNCT
bjp-18180	17	1	structural	structural	ADJ
bjp-18180	17	2	assessment	assessment	NOUN
bjp-18180	17	3	of	of	ADP
bjp-18180	17	4	the	the	DET
bjp-18180	17	5	modeled	model	VERB
bjp-18180	17	6	protein	protein	NOUN
bjp-18180	17	7	and	and	CCONJ
bjp-18180	17	8	confirmed	confirm	VERB
bjp-18180	17	9	the	the	DET
bjp-18180	17	10	quality	quality	NOUN
bjp-18180	17	11	of	of	ADP
bjp-18180	17	12	the	the	DET
bjp-18180	17	13	model	model	NOUN
bjp-18180	17	14	.	.	PUNCT
bjp-18180	18	1	the	the	DET
bjp-18180	18	2	ligands	ligand	NOUN
bjp-18180	18	3	were	be	AUX
bjp-18180	18	4	docked	dock	VERB
bjp-18180	18	5	using	use	VERB
bjp-18180	18	6	autodock	autodock	NOUN
bjp-18180	18	7	4.2	4.2	NUM
bjp-18180	18	8	software	software	NOUN
bjp-18180	18	9	and	and	CCONJ
bjp-18180	18	10	binding	bind	VERB
bjp-18180	18	11	energy	energy	NOUN
bjp-18180	18	12	was	be	AUX
bjp-18180	18	13	reported	report	VERB
bjp-18180	18	14	.	.	PUNCT
bjp-18180	19	1	the	the	DET
bjp-18180	19	2	compound	compound	PROPN
bjp-18180	19	3	xm9	xm9	PROPN
bjp-18180	19	4	,	,	PUNCT
bjp-18180	19	5	xn2	xn2	PROPN
bjp-18180	19	6	,	,	PUNCT
bjp-18180	19	7	xm7	xm7	PROPN
bjp-18180	19	8	,	,	PUNCT
bjp-18180	19	9	xlnu	xlnu	PROPN
bjp-18180	19	10	and	and	CCONJ
bjp-18180	19	11	xns	xns	PROPN
bjp-18180	19	12	scored	score	VERB
bjp-18180	19	13	lowest	low	ADJ
bjp-18180	19	14	binding	bind	VERB
bjp-18180	19	15	energy	energy	NOUN
bjp-18180	19	16	and	and	CCONJ
bjp-18180	19	17	highest	high	ADJ
bjp-18180	19	18	binding	binding	ADJ
bjp-18180	19	19	affinity	affinity	NOUN
bjp-18180	19	20	.	.	PUNCT
bjp-18180	20	1	the	the	DET
bjp-18180	20	2	interaction	interaction	NOUN
bjp-18180	20	3	sites	site	NOUN
bjp-18180	20	4	and	and	CCONJ
bjp-18180	20	5	the	the	DET
bjp-18180	20	6	hydrogen	hydrogen	NOUN
bjp-18180	20	7	bond	bond	NOUN
bjp-18180	20	8	were	be	AUX
bjp-18180	20	9	observed	observe	VERB
bjp-18180	20	10	.	.	PUNCT
bjp-18180	21	1	article	article	NOUN
bjp-18180	21	2	info	info	NOUN
bjp-18180	21	3	received	receive	VERB
bjp-18180	21	4	:	:	PUNCT
bjp-18180	21	5	3	3	NUM
bjp-18180	21	6	march	march	NOUN
bjp-18180	21	7	2014	2014	NUM
bjp-18180	21	8	accepted	accept	VERB
bjp-18180	21	9	:	:	PUNCT
bjp-18180	21	10	23	23	NUM
bjp-18180	21	11	march	march	NOUN
bjp-18180	21	12	2014	2014	NUM
bjp-18180	21	13	available	available	ADJ
bjp-18180	21	14	online	online	ADV
bjp-18180	21	15	:	:	PUNCT
bjp-18180	21	16	5	5	NUM
bjp-18180	21	17	may	may	PROPN
bjp-18180	21	18	2014	2014	NUM
bjp-18180	21	19	doi	doi	NOUN
bjp-18180	21	20	:	:	PUNCT
bjp-18180	21	21	10.3329	10.3329	NUM
bjp-18180	21	22	/	/	SYM
bjp-18180	21	23	bjp.v9i2.18180	bjp.v9i2.18180	PROPN
bjp-18180	21	24	cite	cite	VERB
bjp-18180	21	25	this	this	DET
bjp-18180	21	26	article	article	NOUN
bjp-18180	21	27	:	:	PUNCT
bjp-18180	21	28	nainwal	nainwal	NOUN
bjp-18180	21	29	lm	lm	PROPN
bjp-18180	21	30	,	,	PUNCT
bjp-18180	21	31	parida	parida	PROPN
bjp-18180	21	32	p	p	PROPN
bjp-18180	21	33	,	,	PUNCT
bjp-18180	21	34	das	das	PROPN
bjp-18180	21	35	a	a	DET
bjp-18180	21	36	,	,	PUNCT
bjp-18180	21	37	bairy	bairy	PROPN
bjp-18180	21	38	ps	ps	PROPN
bjp-18180	21	39	.	.	PROPN
bjp-18180	21	40	design	design	NOUN
bjp-18180	21	41	and	and	CCONJ
bjp-18180	21	42	docking	docking	NOUN
bjp-18180	21	43	of	of	ADP
bjp-18180	21	44	novel	novel	ADJ
bjp-18180	21	45	series	series	NOUN
bjp-18180	21	46	of	of	ADP
bjp-18180	21	47	hybrid	hybrid	ADJ
bjp-18180	21	48	xanthones	xanthone	NOUN
bjp-18180	21	49	as	as	ADP
bjp-18180	21	50	anticancer	anticancer	NOUN
bjp-18180	21	51	agent	agent	NOUN
bjp-18180	21	52	to	to	PART
bjp-18180	21	53	target	target	VERB
bjp-18180	21	54	human	human	ADJ
bjp-18180	21	55	dna	dna	NOUN
bjp-18180	21	56	topoisomerase	topoisomerase	VERB
bjp-18180	21	57	2	2	NUM
bjp-18180	21	58	-	-	PUNCT
bjp-18180	21	59	alpha	alpha	NOUN
bjp-18180	21	60	.	.	PUNCT
bjp-18180	22	1	bangladesh	bangladesh	PROPN
bjp-18180	22	2	j	j	PROPN
bjp-18180	22	3	pharmacol	pharmacol	PROPN
bjp-18180	22	4	.	.	PUNCT
bjp-18180	22	5	2014	2014	NUM
bjp-18180	22	6	;	;	PUNCT
bjp-18180	22	7	9	9	NUM
bjp-18180	22	8	:	:	SYM
bjp-18180	22	9	208	208	NUM
bjp-18180	22	10	-	-	SYM
bjp-18180	22	11	17	17	NUM
bjp-18180	22	12	.	.	PUNCT
bjp-18180	23	1	this	this	DET
bjp-18180	23	2	work	work	NOUN
bjp-18180	23	3	is	be	AUX
bjp-18180	23	4	licensed	license	VERB
bjp-18180	23	5	under	under	ADP
bjp-18180	23	6	a	a	DET
bjp-18180	23	7	creative	creative	ADJ
bjp-18180	23	8	commons	common	NOUN
bjp-18180	23	9	attribution	attribution	NOUN
bjp-18180	23	10	3.0	3.0	NUM
bjp-18180	23	11	license	license	NOUN
bjp-18180	23	12	.	.	PUNCT
bjp-18180	24	1	you	you	PRON
bjp-18180	24	2	are	be	AUX
bjp-18180	24	3	free	free	ADJ
bjp-18180	24	4	to	to	PART
bjp-18180	24	5	copy	copy	VERB
bjp-18180	24	6	,	,	PUNCT
bjp-18180	24	7	distribute	distribute	VERB
bjp-18180	24	8	and	and	CCONJ
bjp-18180	24	9	perform	perform	VERB
bjp-18180	24	10	the	the	DET
bjp-18180	24	11	work	work	NOUN
bjp-18180	24	12	.	.	PUNCT
bjp-18180	25	1	you	you	PRON
bjp-18180	25	2	must	must	AUX
bjp-18180	25	3	attribute	attribute	VERB
bjp-18180	25	4	the	the	DET
bjp-18180	25	5	work	work	NOUN
bjp-18180	25	6	in	in	ADP
bjp-18180	25	7	the	the	DET
bjp-18180	25	8	manner	manner	NOUN
bjp-18180	25	9	specified	specify	VERB
bjp-18180	25	10	by	by	ADP
bjp-18180	25	11	the	the	DET
bjp-18180	25	12	author	author	NOUN
bjp-18180	25	13	or	or	CCONJ
bjp-18180	25	14	licensor	licensor	NOUN
bjp-18180	25	15	.	.	PUNCT
bjp-18180	26	1	design	design	NOUN
bjp-18180	26	2	and	and	CCONJ
bjp-18180	26	3	docking	docking	NOUN
bjp-18180	26	4	of	of	ADP
bjp-18180	26	5	novel	novel	ADJ
bjp-18180	26	6	series	series	NOUN
bjp-18180	26	7	of	of	ADP
bjp-18180	26	8	hybrid	hybrid	ADJ
bjp-18180	26	9	xanthones	xanthone	NOUN
bjp-18180	26	10	as	as	ADP
bjp-18180	26	11	anti	anti	ADJ
bjp-18180	26	12	cancer	cancer	NOUN
bjp-18180	26	13	agent	agent	NOUN
bjp-18180	26	14	to	to	PART
bjp-18180	26	15	target	target	VERB
bjp-18180	26	16	human	human	ADJ
bjp-18180	26	17	dna	dna	NOUN
bjp-18180	26	18	topoisomerase	topoisomerase	NOUN
bjp-18180	26	19	2	2	NUM
bjp-18180	26	20	-	-	PUNCT
bjp-18180	26	21	alpha	alpha	NOUN
bjp-18180	26	22	lalit	lalit	PROPN
bjp-18180	26	23	mohan	mohan	PROPN
bjp-18180	26	24	nainwal1	nainwal1	PROPN
bjp-18180	26	25	,	,	PUNCT
bjp-18180	26	26	pratap	pratap	PROPN
bjp-18180	26	27	parida2	parida2	PROPN
bjp-18180	26	28	,	,	PUNCT
bjp-18180	26	29	aparoop	aparoop	NOUN
bjp-18180	26	30	das1	das1	NOUN
bjp-18180	26	31	and	and	CCONJ
bjp-18180	26	32	partha	partha	PROPN
bjp-18180	26	33	sarathi	sarathi	PROPN
bjp-18180	26	34	bairy1	bairy1	PROPN
bjp-18180	26	35	1department	1department	NUM
bjp-18180	26	36	of	of	ADP
bjp-18180	26	37	pharmaceutical	pharmaceutical	NOUN
bjp-18180	26	38	sciences	science	NOUN
bjp-18180	26	39	,	,	PUNCT
bjp-18180	26	40	dibrugarh	dibrugarh	NOUN
bjp-18180	26	41	university	university	NOUN
bjp-18180	26	42	,	,	PUNCT
bjp-18180	26	43	assam	assam	PROPN
bjp-18180	26	44	786	786	NUM
bjp-18180	26	45	004	004	NUM
bjp-18180	26	46	,	,	PUNCT
bjp-18180	26	47	india	india	PROPN
bjp-18180	26	48	;	;	PUNCT
bjp-18180	26	49	2centre	2centre	NUM
bjp-18180	26	50	for	for	ADP
bjp-18180	26	51	studies	study	NOUN
bjp-18180	26	52	in	in	ADP
bjp-18180	26	53	biotechnology	biotechnology	NOUN
bjp-18180	26	54	,	,	PUNCT
bjp-18180	26	55	dibrugarh	dibrugarh	NOUN
bjp-18180	26	56	university	university	NOUN
bjp-18180	26	57	,	,	PUNCT
bjp-18180	26	58	assam	assam	PROPN
bjp-18180	26	59	786	786	NUM
bjp-18180	26	60	004	004	NUM
bjp-18180	26	61	,	,	PUNCT
bjp-18180	26	62	india	india	PROPN
bjp-18180	26	63	.	.	PUNCT
bjp-18180	27	1	materials	material	NOUN
bjp-18180	27	2	and	and	CCONJ
bjp-18180	27	3	methods	method	NOUN
bjp-18180	27	4	sequence	sequence	NOUN
bjp-18180	27	5	retrieval	retrieval	NOUN
bjp-18180	27	6	and	and	CCONJ
bjp-18180	27	7	template	template	NOUN
bjp-18180	27	8	identification	identification	NOUN
bjp-18180	27	9	primary	primary	ADJ
bjp-18180	27	10	sequence	sequence	NOUN
bjp-18180	27	11	of	of	ADP
bjp-18180	27	12	human	human	ADJ
bjp-18180	27	13	dna	dna	PROPN
bjp-18180	27	14	topoisomerase	topoisomerase	PROPN
bjp-18180	27	15	ii	ii	PROPN
bjp-18180	27	16	was	be	AUX
bjp-18180	27	17	retrieved	retrieve	VERB
bjp-18180	27	18	in	in	ADP
bjp-18180	27	19	fasta	fasta	PROPN
bjp-18180	27	20	format	format	NOUN
bjp-18180	27	21	from	from	ADP
bjp-18180	27	22	national	national	ADJ
bjp-18180	27	23	center	center	NOUN
bjp-18180	27	24	for	for	ADP
bjp-18180	27	25	biotechnology	biotechnology	NOUN
bjp-18180	27	26	information	information	NOUN
bjp-18180	27	27	(	(	PUNCT
bjp-18180	27	28	http://www.ncbi.nlm	http://www.ncbi.nlm	PROPN
bjp-18180	27	29	.	.	PUNCT
bjp-18180	28	1	nih	nih	PROPN
bjp-18180	28	2	.	.	PROPN
bjp-18180	28	3	gov	gov	PROPN
bjp-18180	28	4	/	/	SYM
bjp-18180	28	5	protein/	protein/	NOUN
bjp-18180	28	6	)	)	PUNCT
bjp-18180	28	7	protein	protein	NOUN
bjp-18180	28	8	database	database	NOUN
bjp-18180	28	9	(	(	PUNCT
bjp-18180	28	10	gi	gi	NOUN
bjp-18180	28	11	:	:	PUNCT
bjp-18180	28	12	13959709	13959709	NUM
bjp-18180	28	13	)	)	PUNCT
bjp-18180	28	14	.	.	PUNCT
bjp-18180	29	1	homology	homology	NOUN
bjp-18180	29	2	modeling	modeling	NOUN
bjp-18180	29	3	is	be	AUX
bjp-18180	29	4	currently	currently	ADV
bjp-18180	29	5	a	a	DET
bjp-18180	29	6	nifty	nifty	ADJ
bjp-18180	29	7	and	and	CCONJ
bjp-18180	29	8	an	an	DET
bjp-18180	29	9	accurate	accurate	ADJ
bjp-18180	29	10	advantageous	advantageous	ADJ
bjp-18180	29	11	tool	tool	NOUN
bjp-18180	29	12	for	for	ADP
bjp-18180	29	13	generating	generate	VERB
bjp-18180	29	14	reliable	reliable	ADJ
bjp-18180	29	15	three	three	NUM
bjp-18180	29	16	-	-	PUNCT
bjp-18180	29	17	dimensional	dimensional	ADJ
bjp-18180	29	18	protein	protein	NOUN
bjp-18180	29	19	structure	structure	NOUN
bjp-18180	29	20	models	model	NOUN
bjp-18180	29	21	for	for	ADP
bjp-18180	29	22	those	those	DET
bjp-18180	29	23	proteins	protein	NOUN
bjp-18180	29	24	whose	whose	DET
bjp-18180	29	25	structures	structure	NOUN
bjp-18180	29	26	are	be	AUX
bjp-18180	29	27	not	not	PART
bjp-18180	29	28	known	know	VERB
bjp-18180	29	29	/	/	SYM
bjp-18180	29	30	identified	identify	VERB
bjp-18180	29	31	,	,	PUNCT
bjp-18180	29	32	till	till	SCONJ
bjp-18180	29	33	now	now	ADV
bjp-18180	29	34	and	and	CCONJ
bjp-18180	29	35	is	be	AUX
bjp-18180	29	36	routinely	routinely	ADV
bjp-18180	29	37	used	use	VERB
bjp-18180	29	38	in	in	ADP
bjp-18180	29	39	many	many	ADJ
bjp-18180	29	40	practical	practical	ADJ
bjp-18180	29	41	applications	application	NOUN
bjp-18180	29	42	.	.	PUNCT
bjp-18180	30	1	in	in	ADP
bjp-18180	30	2	homology	homology	NOUN
bjp-18180	30	3	modeling	modeling	NOUN
bjp-18180	30	4	methods	method	NOUN
bjp-18180	30	5	experimental	experimental	ADJ
bjp-18180	30	6	protein	protein	NOUN
bjp-18180	30	7	structures	structure	NOUN
bjp-18180	30	8	termed	term	VERB
bjp-18180	30	9	as	as	SCONJ
bjp-18180	30	10	"	"	PUNCT
bjp-18180	30	11	templates	template	NOUN
bjp-18180	30	12	"	"	PUNCT
bjp-18180	30	13	are	be	AUX
bjp-18180	30	14	used	use	VERB
bjp-18180	30	15	to	to	PART
bjp-18180	30	16	dimension	dimension	VERB
bjp-18180	30	17	a	a	DET
bjp-18180	30	18	new	new	ADJ
bjp-18180	30	19	model	model	NOUN
bjp-18180	30	20	of	of	ADP
bjp-18180	30	21	evolutionary	evolutionary	ADJ
bjp-18180	30	22	related	relate	VERB
bjp-18180	30	23	proteins	protein	NOUN
bjp-18180	30	24	,	,	PUNCT
bjp-18180	30	25	termed	term	VERB
bjp-18180	30	26	as	as	ADP
bjp-18180	30	27	"	"	PUNCT
bjp-18180	30	28	targets	target	NOUN
bjp-18180	30	29	"	"	PUNCT
bjp-18180	30	30	.	.	PUNCT
bjp-18180	31	1	retrieved	retrieve	VERB
bjp-18180	31	2	sequence	sequence	NOUN
bjp-18180	31	3	was	be	AUX
bjp-18180	31	4	submitted	submit	VERB
bjp-18180	31	5	to	to	PART
bjp-18180	31	6	swissmodel	swissmodel	VERB
bjp-18180	31	7	homology	homology	NOUN
bjp-18180	31	8	modeling	model	VERB
bjp-18180	31	9	tool	tool	NOUN
bjp-18180	31	10	for	for	ADP
bjp-18180	31	11	template	template	NOUN
bjp-18180	31	12	identification	identification	NOUN
bjp-18180	31	13	of	of	ADP
bjp-18180	31	14	the	the	DET
bjp-18180	31	15	target	target	NOUN
bjp-18180	31	16	sequence	sequence	NOUN
bjp-18180	31	17	.	.	PUNCT
bjp-18180	32	1	the	the	DET
bjp-18180	32	2	most	most	ADV
bjp-18180	32	3	important	important	ADJ
bjp-18180	32	4	and	and	CCONJ
bjp-18180	32	5	decisive	decisive	ADJ
bjp-18180	32	6	rung	rung	NOUN
bjp-18180	32	7	for	for	ADP
bjp-18180	32	8	developing	develop	VERB
bjp-18180	32	9	a	a	DET
bjp-18180	32	10	desired	desire	VERB
bjp-18180	32	11	model	model	NOUN
bjp-18180	32	12	of	of	ADP
bjp-18180	32	13	protein	protein	NOUN
bjp-18180	32	14	is	be	AUX
bjp-18180	32	15	the	the	DET
bjp-18180	32	16	finding	find	VERB
bjp-18180	32	17	a	a	DET
bjp-18180	32	18	tentative	tentative	ADJ
bjp-18180	32	19	three	three	NUM
bjp-18180	32	20	-	-	PUNCT
bjp-18180	32	21	dimensional	dimensional	ADJ
bjp-18180	32	22	structure	structure	NOUN
bjp-18180	32	23	of	of	ADP
bjp-18180	32	24	an	an	DET
bjp-18180	32	25	interrelated	interrelated	ADJ
bjp-18180	32	26	homologous	homologous	ADJ
bjp-18180	32	27	protein	protein	NOUN
bjp-18180	32	28	(	(	PUNCT
bjp-18180	32	29	the	the	DET
bjp-18180	32	30	"	"	PUNCT
bjp-18180	32	31	template	template	NOUN
bjp-18180	32	32	"	"	PUNCT
bjp-18180	32	33	)	)	PUNCT
bjp-18180	32	34	.	.	PUNCT
bjp-18180	33	1	for	for	ADP
bjp-18180	33	2	fetching	fetch	VERB
bjp-18180	33	3	of	of	ADP
bjp-18180	33	4	all	all	DET
bjp-18180	33	5	the	the	DET
bjp-18180	33	6	target	target	NOUN
bjp-18180	33	7	sequences	sequence	NOUN
bjp-18180	33	8	blast	blast	NOUN
bjp-18180	33	9	server	server	NOUN
bjp-18180	33	10	of	of	ADP
bjp-18180	33	11	ncbi	ncbi	PROPN
bjp-18180	33	12	against	against	ADP
bjp-18180	33	13	pdb	pdb	PROPN
bjp-18180	33	14	(	(	PUNCT
bjp-18180	33	15	protein	protein	NOUN
bjp-18180	33	16	data	data	PROPN
bjp-18180	33	17	bank	bank	PROPN
bjp-18180	33	18	)	)	PUNCT
bjp-18180	33	19	database	database	NOUN
bjp-18180	33	20	were	be	AUX
bjp-18180	33	21	used	use	VERB
bjp-18180	33	22	.	.	PUNCT
bjp-18180	34	1	the	the	DET
bjp-18180	34	2	threshold	threshold	NOUN
bjp-18180	34	3	value	value	NOUN
bjp-18180	34	4	of	of	ADP
bjp-18180	34	5	10	10	NUM
bjp-18180	34	6	and	and	CCONJ
bjp-18180	34	7	the	the	DET
bjp-18180	34	8	word	word	NOUN
bjp-18180	34	9	size	size	NOUN
bjp-18180	34	10	3	3	NUM
bjp-18180	34	11	were	be	AUX
bjp-18180	34	12	selected	select	VERB
bjp-18180	34	13	as	as	ADP
bjp-18180	34	14	general	general	ADJ
bjp-18180	34	15	parameters	parameter	NOUN
bjp-18180	34	16	for	for	ADP
bjp-18180	34	17	blast	blast	NOUN
bjp-18180	34	18	.	.	PUNCT
bjp-18180	35	1	the	the	DET
bjp-18180	35	2	blosum-62	blosum-62	PROPN
bjp-18180	35	3	matrix	matrix	NOUN
bjp-18180	35	4	was	be	AUX
bjp-18180	35	5	chosen	choose	VERB
bjp-18180	35	6	with	with	ADP
bjp-18180	35	7	a	a	DET
bjp-18180	35	8	gap	gap	NOUN
bjp-18180	35	9	penalty	penalty	NOUN
bjp-18180	35	10	of	of	ADP
bjp-18180	35	11	11	11	NUM
bjp-18180	35	12	for	for	ADP
bjp-18180	35	13	1	1	NUM
bjp-18180	35	14	mismatch	mismatch	NOUN
bjp-18180	35	15	.	.	PUNCT
bjp-18180	36	1	templates	template	NOUN
bjp-18180	36	2	which	which	PRON
bjp-18180	36	3	shows	show	VERB
bjp-18180	36	4	a	a	DET
bjp-18180	36	5	high	high	ADJ
bjp-18180	36	6	percenttage	percenttage	NOUN
bjp-18180	36	7	of	of	ADP
bjp-18180	36	8	sequence	sequence	NOUN
bjp-18180	36	9	identity	identity	NOUN
bjp-18180	36	10	,	,	PUNCT
bjp-18180	36	11	the	the	DET
bjp-18180	36	12	query	query	NOUN
bjp-18180	36	13	coverage	coverage	NOUN
bjp-18180	36	14	and	and	CCONJ
bjp-18180	36	15	the	the	DET
bjp-18180	36	16	score	score	NOUN
bjp-18180	36	17	of	of	ADP
bjp-18180	36	18	the	the	DET
bjp-18180	36	19	alignment	alignment	NOUN
bjp-18180	36	20	which	which	DET
bjp-18180	36	21	hunt	hunt	NOUN
bjp-18180	36	22	for	for	ADP
bjp-18180	36	23	to	to	PART
bjp-18180	36	24	build	build	VERB
bjp-18180	36	25	a	a	DET
bjp-18180	36	26	quality	quality	NOUN
bjp-18180	36	27	model	model	NOUN
bjp-18180	36	28	were	be	AUX
bjp-18180	36	29	scanned	scan	VERB
bjp-18180	36	30	.	.	PUNCT
bjp-18180	37	1	for	for	ADP
bjp-18180	37	2	analyzing	analyze	VERB
bjp-18180	37	3	the	the	DET
bjp-18180	37	4	different	different	ADJ
bjp-18180	37	5	template	template	NOUN
bjp-18180	37	6	and	and	CCONJ
bjp-18180	37	7	its	its	PRON
bjp-18180	37	8	tm	tm	NOUN
bjp-18180	37	9	-	-	NOUN
bjp-18180	37	10	score	score	NOUN
bjp-18180	37	11	for	for	ADP
bjp-18180	37	12	better	well	ADJ
bjp-18180	37	13	understanding	understanding	NOUN
bjp-18180	37	14	of	of	ADP
bjp-18180	37	15	the	the	DET
bjp-18180	37	16	templates	template	NOUN
bjp-18180	37	17	lomets	lomet	NOUN
bjp-18180	37	18	(	(	PUNCT
bjp-18180	37	19	http://zhanglab.ccmb.med	http://zhanglab.ccmb.me	VERB
bjp-18180	37	20	.	.	PUNCT
bjp-18180	38	1	umich.edu/lomets/	umich.edu/lomets/	NOUN
bjp-18180	38	2	)	)	PUNCT
bjp-18180	38	3	was	be	AUX
bjp-18180	38	4	also	also	ADV
bjp-18180	38	5	used	use	VERB
bjp-18180	38	6	.	.	PUNCT
bjp-18180	39	1	the	the	DET
bjp-18180	39	2	selected	select	VERB
bjp-18180	39	3	templates	template	NOUN
bjp-18180	39	4	which	which	PRON
bjp-18180	39	5	were	be	AUX
bjp-18180	39	6	used	use	VERB
bjp-18180	39	7	for	for	ADP
bjp-18180	39	8	dimensioning	dimension	VERB
bjp-18180	39	9	new	new	ADJ
bjp-18180	39	10	protein	protein	NOUN
bjp-18180	39	11	model	model	NOUN
bjp-18180	39	12	were	be	AUX
bjp-18180	39	13	retrieved	retrieve	VERB
bjp-18180	39	14	from	from	ADP
bjp-18180	39	15	rcsb	rcsb	NOUN
bjp-18180	39	16	(	(	PUNCT
bjp-18180	39	17	research	research	NOUN
bjp-18180	39	18	collaboratory	collaboratory	NOUN
bjp-18180	39	19	for	for	ADP
bjp-18180	39	20	structural	structural	ADJ
bjp-18180	39	21	bioinformatics	bioinformatics	NOUN
bjp-18180	39	22	)	)	PUNCT
bjp-18180	39	23	protein	protein	NOUN
bjp-18180	39	24	data	datum	NOUN
bjp-18180	39	25	bank	bank	PROPN
bjp-18180	39	26	.	.	PUNCT
bjp-18180	40	1	sequence	sequence	NOUN
bjp-18180	40	2	alignment	alignment	VERB
bjp-18180	40	3	a	a	DET
bjp-18180	40	4	gonnet	gonnet	NOUN
bjp-18180	40	5	protein	protein	NOUN
bjp-18180	40	6	weight	weight	NOUN
bjp-18180	40	7	matrix	matrix	NOUN
bjp-18180	40	8	of	of	ADP
bjp-18180	40	9	clustal	clustal	ADJ
bjp-18180	40	10	w	w	NOUN
bjp-18180	40	11	was	be	AUX
bjp-18180	40	12	used	use	VERB
bjp-18180	40	13	to	to	PART
bjp-18180	40	14	study	study	VERB
bjp-18180	40	15	the	the	DET
bjp-18180	40	16	matching	matching	NOUN
bjp-18180	40	17	between	between	ADP
bjp-18180	40	18	target	target	NOUN
bjp-18180	40	19	and	and	CCONJ
bjp-18180	40	20	template	template	NOUN
bjp-18180	40	21	sequences	sequence	NOUN
bjp-18180	40	22	.	.	PUNCT
bjp-18180	41	1	based	base	VERB
bjp-18180	41	2	on	on	ADP
bjp-18180	41	3	the	the	DET
bjp-18180	41	4	sequence	sequence	NOUN
bjp-18180	41	5	,	,	PUNCT
bjp-18180	41	6	pair	pair	VERB
bjp-18180	41	7	wise	wise	ADJ
bjp-18180	41	8	and	and	CCONJ
bjp-18180	41	9	multiple	multiple	ADJ
bjp-18180	41	10	sequence	sequence	NOUN
bjp-18180	41	11	alignment	alignment	NOUN
bjp-18180	41	12	were	be	AUX
bjp-18180	41	13	performed	perform	VERB
bjp-18180	41	14	.	.	PUNCT
bjp-18180	42	1	for	for	ADP
bjp-18180	42	2	alignment	alignment	NOUN
bjp-18180	42	3	,	,	PUNCT
bjp-18180	42	4	the	the	DET
bjp-18180	42	5	alignment	alignment	NOUN
bjp-18180	42	6	tools	tool	NOUN
bjp-18180	42	7	,	,	PUNCT
bjp-18180	42	8	t	t	NOUN
bjp-18180	42	9	-	-	PUNCT
bjp-18180	42	10	coffee	coffee	NOUN
bjp-18180	42	11	,	,	PUNCT
bjp-18180	42	12	clustal	clustal	PROPN
bjp-18180	42	13	w	w	NOUN
bjp-18180	42	14	from	from	ADP
bjp-18180	42	15	ebi	ebi	NOUN
bjp-18180	42	16	(	(	PUNCT
bjp-18180	42	17	european	european	PROPN
bjp-18180	42	18	bioinformatics	bioinformatics	PROPN
bjp-18180	42	19	institute	institute	PROPN
bjp-18180	42	20	)	)	PUNCT
bjp-18180	42	21	was	be	AUX
bjp-18180	42	22	used	use	VERB
bjp-18180	42	23	to	to	PART
bjp-18180	42	24	better	well	ADV
bjp-18180	42	25	understand	understand	VERB
bjp-18180	42	26	resultant	resultant	NOUN
bjp-18180	42	27	sequence	sequence	NOUN
bjp-18180	42	28	alignment	alignment	NOUN
bjp-18180	42	29	matches	match	NOUN
bjp-18180	42	30	,	,	PUNCT
bjp-18180	42	31	its	its	PRON
bjp-18180	42	32	mismatches	mismatch	NOUN
bjp-18180	42	33	and	and	CCONJ
bjp-18180	42	34	mutations	mutation	NOUN
bjp-18180	42	35	was	be	AUX
bjp-18180	42	36	viewed	view	VERB
bjp-18180	42	37	in	in	ADP
bjp-18180	42	38	jalview	jalview	NOUN
bjp-18180	42	39	.	.	PUNCT
bjp-18180	43	1	homology	homology	NOUN
bjp-18180	43	2	modeling	model	VERB
bjp-18180	43	3	homology	homology	NOUN
bjp-18180	43	4	modeling	modeling	NOUN
bjp-18180	43	5	builds	build	VERB
bjp-18180	43	6	a	a	DET
bjp-18180	43	7	neat	neat	ADJ
bjp-18180	43	8	relationship	relationship	NOUN
bjp-18180	43	9	between	between	ADP
bjp-18180	43	10	protein	protein	NOUN
bjp-18180	43	11	primary	primary	ADJ
bjp-18180	43	12	and	and	CCONJ
bjp-18180	43	13	secondary	secondary	ADJ
bjp-18180	43	14	structure	structure	NOUN
bjp-18180	43	15	.	.	PUNCT
bjp-18180	44	1	it	it	PRON
bjp-18180	44	2	is	be	AUX
bjp-18180	44	3	very	very	ADV
bjp-18180	44	4	clear	clear	ADJ
bjp-18180	44	5	to	to	PART
bjp-18180	44	6	understand	understand	VERB
bjp-18180	44	7	the	the	DET
bjp-18180	44	8	function	function	NOUN
bjp-18180	44	9	of	of	ADP
bjp-18180	44	10	protein	protein	NOUN
bjp-18180	44	11	computationally	computationally	ADV
bjp-18180	44	12	by	by	ADP
bjp-18180	44	13	comparative	comparative	ADJ
bjp-18180	44	14	modeling	modeling	NOUN
bjp-18180	44	15	of	of	ADP
bjp-18180	44	16	a	a	DET
bjp-18180	44	17	target	target	NOUN
bjp-18180	44	18	protein	protein	NOUN
bjp-18180	44	19	sequences	sequence	NOUN
bjp-18180	44	20	with	with	ADP
bjp-18180	44	21	its	its	PRON
bjp-18180	44	22	template	template	NOUN
bjp-18180	44	23	which	which	PRON
bjp-18180	44	24	is	be	AUX
bjp-18180	44	25	an	an	DET
bjp-18180	44	26	experimental	experimental	ADJ
bjp-18180	44	27	(	(	PUNCT
bjp-18180	44	28	xrd	xrd	NOUN
bjp-18180	44	29	or	or	CCONJ
bjp-18180	44	30	nmr	nmr	NOUN
bjp-18180	44	31	)	)	PUNCT
bjp-18180	44	32	protein	protein	NOUN
bjp-18180	44	33	structure	structure	NOUN
bjp-18180	44	34	this	this	DET
bjp-18180	44	35	supposition	supposition	NOUN
bjp-18180	44	36	provides	provide	VERB
bjp-18180	44	37	an	an	DET
bjp-18180	44	38	exclusive	exclusive	ADJ
bjp-18180	44	39	hypothesis	hypothesis	NOUN
bjp-18180	44	40	that	that	SCONJ
bjp-18180	44	41	if	if	SCONJ
bjp-18180	44	42	the	the	DET
bjp-18180	44	43	tertiary	tertiary	ADJ
bjp-18180	44	44	structure	structure	NOUN
bjp-18180	44	45	of	of	ADP
bjp-18180	44	46	two	two	NUM
bjp-18180	44	47	proteins	protein	NOUN
bjp-18180	44	48	are	be	AUX
bjp-18180	44	49	similar	similar	ADJ
bjp-18180	44	50	,	,	PUNCT
bjp-18180	44	51	they	they	PRON
bjp-18180	44	52	must	must	AUX
bjp-18180	44	53	shares	share	VERB
bjp-18180	44	54	high	high	ADJ
bjp-18180	44	55	percentage	percentage	NOUN
bjp-18180	44	56	of	of	ADP
bjp-18180	44	57	similarity	similarity	NOUN
bjp-18180	44	58	scores	score	NOUN
bjp-18180	44	59	or	or	CCONJ
bjp-18180	44	60	in	in	ADP
bjp-18180	44	61	other	other	ADJ
bjp-18180	44	62	words	word	NOUN
bjp-18180	44	63	,	,	PUNCT
bjp-18180	44	64	the	the	DET
bjp-18180	44	65	tertiary	tertiary	ADJ
bjp-18180	44	66	structure	structure	NOUN
bjp-18180	44	67	of	of	ADP
bjp-18180	44	68	two	two	NUM
bjp-18180	44	69	proteins	protein	NOUN
bjp-18180	44	70	are	be	AUX
bjp-18180	44	71	similar	similar	ADJ
bjp-18180	44	72	and	and	CCONJ
bjp-18180	44	73	shares	share	VERB
bjp-18180	44	74	high	high	ADJ
bjp-18180	44	75	percentage	percentage	NOUN
bjp-18180	44	76	of	of	ADP
bjp-18180	44	77	similarity	similarity	NOUN
bjp-18180	44	78	scores	score	NOUN
bjp-18180	44	79	only	only	ADV
bjp-18180	44	80	,	,	PUNCT
bjp-18180	44	81	when	when	SCONJ
bjp-18180	44	82	they	they	PRON
bjp-18180	44	83	are	be	AUX
bjp-18180	44	84	similar	similar	ADJ
bjp-18180	44	85	(	(	PUNCT
bjp-18180	44	86	dong	dong	NOUN
bjp-18180	44	87	and	and	CCONJ
bjp-18180	44	88	berger	berger	PROPN
bjp-18180	44	89	,	,	PUNCT
bjp-18180	44	90	2007	2007	NUM
bjp-18180	44	91	)	)	PUNCT
bjp-18180	44	92	.	.	PUNCT
bjp-18180	45	1	modeller	modeller	NOUN
bjp-18180	45	2	9v11	9v11	PROPN
bjp-18180	45	3	software	software	NOUN
bjp-18180	45	4	was	be	AUX
bjp-18180	45	5	used	use	VERB
bjp-18180	45	6	for	for	ADP
bjp-18180	45	7	protein	protein	NOUN
bjp-18180	45	8	model	model	NOUN
bjp-18180	45	9	building	building	NOUN
bjp-18180	45	10	.	.	PUNCT
bjp-18180	46	1	initially	initially	ADV
bjp-18180	46	2	100	100	NUM
bjp-18180	46	3	models	model	NOUN
bjp-18180	46	4	were	be	AUX
bjp-18180	46	5	designed	design	VERB
bjp-18180	46	6	,	,	PUNCT
bjp-18180	46	7	among	among	ADP
bjp-18180	46	8	them	they	PRON
bjp-18180	46	9	a	a	DET
bjp-18180	46	10	single	single	ADJ
bjp-18180	46	11	model	model	NOUN
bjp-18180	46	12	was	be	AUX
bjp-18180	46	13	selected	select	VERB
bjp-18180	46	14	based	base	VERB
bjp-18180	46	15	on	on	ADP
bjp-18180	46	16	the	the	DET
bjp-18180	46	17	lower	low	ADJ
bjp-18180	46	18	discrete	discrete	ADJ
bjp-18180	46	19	optimized	optimize	VERB
bjp-18180	46	20	protein	protein	NOUN
bjp-18180	46	21	energy	energy	NOUN
bjp-18180	46	22	(	(	PUNCT
bjp-18180	46	23	dope	dope	NOUN
bjp-18180	46	24	)	)	PUNCT
bjp-18180	46	25	scores	score	NOUN
bjp-18180	46	26	for	for	ADP
bjp-18180	46	27	further	further	ADJ
bjp-18180	46	28	analysis	analysis	NOUN
bjp-18180	46	29	.	.	PUNCT
bjp-18180	47	1	structural	structural	ADJ
bjp-18180	47	2	assessment	assessment	NOUN
bjp-18180	47	3	the	the	DET
bjp-18180	47	4	models	model	NOUN
bjp-18180	47	5	were	be	AUX
bjp-18180	47	6	examined	examine	VERB
bjp-18180	47	7	both	both	CCONJ
bjp-18180	47	8	on	on	ADP
bjp-18180	47	9	geometric	geometric	ADJ
bjp-18180	47	10	and	and	CCONJ
bjp-18180	47	11	energetic	energetic	ADJ
bjp-18180	47	12	scale	scale	NOUN
bjp-18180	47	13	for	for	ADP
bjp-18180	47	14	quality	quality	NOUN
bjp-18180	47	15	means	mean	NOUN
bjp-18180	47	16	.	.	PUNCT
bjp-18180	48	1	the	the	DET
bjp-18180	48	2	validation	validation	NOUN
bjp-18180	48	3	of	of	ADP
bjp-18180	48	4	modeled	model	VERB
bjp-18180	48	5	structures	structure	NOUN
bjp-18180	48	6	were	be	AUX
bjp-18180	48	7	done	do	VERB
bjp-18180	48	8	by	by	ADP
bjp-18180	48	9	using	use	VERB
bjp-18180	48	10	procheck	procheck	NOUN
bjp-18180	48	11	(	(	PUNCT
bjp-18180	48	12	nitiss	nitiss	PROPN
bjp-18180	48	13	,	,	PUNCT
bjp-18180	48	14	2009	2009	NUM
bjp-18180	48	15	)	)	PUNCT
bjp-18180	48	16	,	,	PUNCT
bjp-18180	48	17	errat	errat	NOUN
bjp-18180	48	18	(	(	PUNCT
bjp-18180	48	19	bailly	bailly	ADV
bjp-18180	48	20	,	,	PUNCT
bjp-18180	48	21	2012	2012	NUM
bjp-18180	48	22	)	)	PUNCT
bjp-18180	48	23	and	and	CCONJ
bjp-18180	48	24	verify3d	verify3d	NOUN
bjp-18180	48	25	(	(	PUNCT
bjp-18180	48	26	binaschi	binaschi	PROPN
bjp-18180	48	27	et	et	PROPN
bjp-18180	48	28	al	al	PROPN
bjp-18180	48	29	.	.	PROPN
bjp-18180	48	30	,	,	PUNCT
bjp-18180	48	31	2001	2001	NUM
bjp-18180	48	32	)	)	PUNCT
bjp-18180	48	33	.	.	PUNCT
bjp-18180	49	1	procheck	procheck	PROPN
bjp-18180	49	2	rottenly	rottenly	ADV
bjp-18180	49	3	used	use	VERB
bjp-18180	49	4	and	and	CCONJ
bjp-18180	49	5	is	be	AUX
bjp-18180	49	6	an	an	DET
bjp-18180	49	7	important	important	ADJ
bjp-18180	49	8	freeware	freeware	NOUN
bjp-18180	49	9	tool	tool	NOUN
bjp-18180	49	10	,	,	PUNCT
bjp-18180	49	11	deals	deal	NOUN
bjp-18180	49	12	with	with	ADP
bjp-18180	49	13	the	the	DET
bjp-18180	49	14	study	study	NOUN
bjp-18180	49	15	of	of	ADP
bjp-18180	49	16	stereo	stereo	ADJ
bjp-18180	49	17	-	-	PUNCT
bjp-18180	49	18	chemical	chemical	ADJ
bjp-18180	49	19	properties	property	NOUN
bjp-18180	49	20	which	which	PRON
bjp-18180	49	21	could	could	AUX
bjp-18180	49	22	be	be	AUX
bjp-18180	49	23	clearly	clearly	ADV
bjp-18180	49	24	analyzed	analyze	VERB
bjp-18180	49	25	by	by	ADP
bjp-18180	49	26	the	the	DET
bjp-18180	49	27	quality	quality	NOUN
bjp-18180	49	28	of	of	ADP
bjp-18180	49	29	the	the	DET
bjp-18180	49	30	ramachandran	ramachandran	PROPN
bjp-18180	49	31	plot	plot	NOUN
bjp-18180	49	32	,	,	PUNCT
bjp-18180	49	33	peptide	peptide	ADJ
bjp-18180	49	34	bond	bond	NOUN
bjp-18180	49	35	planarity	planarity	NOUN
bjp-18180	49	36	,	,	PUNCT
bjp-18180	49	37	non	non	ADJ
bjp-18180	49	38	-	-	ADJ
bjp-18180	49	39	bonded	bond	VERB
bjp-18180	49	40	interactions	interaction	NOUN
bjp-18180	49	41	,	,	PUNCT
bjp-18180	49	42	main	main	ADJ
bjp-18180	49	43	chain	chain	NOUN
bjp-18180	49	44	hydrogen	hydrogen	NOUN
bjp-18180	49	45	bond	bond	NOUN
bjp-18180	49	46	energy	energy	NOUN
bjp-18180	49	47	,	,	PUNCT
bjp-18180	49	48	c	c	PROPN
bjp-18180	49	49	chiralities	chiralitie	NOUN
bjp-18180	49	50	and	and	CCONJ
bjp-18180	49	51	overall	overall	ADJ
bjp-18180	49	52	g	g	PROPN
bjp-18180	49	53	factor	factor	NOUN
bjp-18180	49	54	.	.	PUNCT
bjp-18180	50	1	errat	errat	PROPN
bjp-18180	50	2	is	be	AUX
bjp-18180	50	3	a	a	DET
bjp-18180	50	4	protein	protein	NOUN
bjp-18180	50	5	structure	structure	NOUN
bjp-18180	50	6	verification	verification	NOUN
bjp-18180	50	7	algorithm	algorithm	NOUN
bjp-18180	50	8	which	which	PRON
bjp-18180	50	9	analyzes	analyze	VERB
bjp-18180	50	10	the	the	DET
bjp-18180	50	11	statistics	statistic	NOUN
bjp-18180	50	12	of	of	ADP
bjp-18180	50	13	non	non	ADJ
bjp-18180	50	14	-	-	ADJ
bjp-18180	50	15	bonded	bond	VERB
bjp-18180	50	16	interactions	interaction	NOUN
bjp-18180	50	17	between	between	ADP
bjp-18180	50	18	different	different	ADJ
bjp-18180	50	19	atom	atom	NOUN
bjp-18180	50	20	types	type	NOUN
bjp-18180	50	21	,	,	PUNCT
bjp-18180	50	22	which	which	PRON
bjp-18180	50	23	in	in	ADP
bjp-18180	50	24	turn	turn	NOUN
bjp-18180	50	25	gives	give	VERB
bjp-18180	50	26	the	the	DET
bjp-18180	50	27	reliability	reliability	NOUN
bjp-18180	50	28	to	to	ADP
bjp-18180	50	29	the	the	DET
bjp-18180	50	30	model	model	NOUN
bjp-18180	50	31	.	.	PUNCT
bjp-18180	51	1	to	to	PART
bjp-18180	51	2	check	check	VERB
bjp-18180	51	3	the	the	DET
bjp-18180	51	4	compatibility	compatibility	NOUN
bjp-18180	51	5	of	of	ADP
bjp-18180	51	6	the	the	DET
bjp-18180	51	7	atomic	atomic	ADJ
bjp-18180	51	8	models	model	NOUN
bjp-18180	51	9	with	with	ADP
bjp-18180	51	10	its	its	PRON
bjp-18180	51	11	own	own	ADJ
bjp-18180	51	12	amino	amino	NOUN
bjp-18180	51	13	acid	acid	NOUN
bjp-18180	51	14	sequence	sequence	NOUN
bjp-18180	51	15	,	,	PUNCT
bjp-18180	51	16	verify3d	verify3d	NOUN
bjp-18180	51	17	was	be	AUX
bjp-18180	51	18	used	use	VERB
bjp-18180	51	19	.	.	PUNCT
bjp-18180	52	1	a	a	DET
bjp-18180	52	2	high	high	ADJ
bjp-18180	52	3	verify3d	verify3d	NOUN
bjp-18180	52	4	profile	profile	NOUN
bjp-18180	52	5	score	score	NOUN
bjp-18180	52	6	shows	show	VERB
bjp-18180	52	7	the	the	DET
bjp-18180	52	8	healthier	healthy	ADJ
bjp-18180	52	9	quality	quality	NOUN
bjp-18180	52	10	of	of	ADP
bjp-18180	52	11	model	model	NOUN
bjp-18180	52	12	.	.	PUNCT
bjp-18180	53	1	preparation	preparation	NOUN
bjp-18180	53	2	of	of	ADP
bjp-18180	53	3	protein	protein	NOUN
bjp-18180	53	4	structure	structure	NOUN
bjp-18180	53	5	topoisomerase	topoisomerase	NOUN
bjp-18180	53	6	ii	ii	NOUN
bjp-18180	53	7	protein	protein	NOUN
bjp-18180	53	8	is	be	AUX
bjp-18180	53	9	big	big	ADJ
bjp-18180	53	10	protein	protein	NOUN
bjp-18180	53	11	,	,	PUNCT
bjp-18180	53	12	having	have	VERB
bjp-18180	53	13	1531	1531	NUM
bjp-18180	53	14	amino	amino	NOUN
bjp-18180	53	15	acid	acid	NOUN
bjp-18180	53	16	residues	residue	NOUN
bjp-18180	53	17	.	.	PUNCT
bjp-18180	54	1	preparation	preparation	NOUN
bjp-18180	54	2	of	of	ADP
bjp-18180	54	3	favorable	favorable	ADJ
bjp-18180	54	4	binding	bind	VERB
bjp-18180	54	5	site	site	NOUN
bjp-18180	54	6	was	be	AUX
bjp-18180	54	7	done	do	VERB
bjp-18180	54	8	using	use	VERB
bjp-18180	54	9	autodock	autodock	NOUN
bjp-18180	54	10	4.2	4.2	NUM
bjp-18180	54	11	tools	tool	NOUN
bjp-18180	54	12	.	.	PUNCT
bjp-18180	55	1	before	before	ADP
bjp-18180	55	2	going	go	VERB
bjp-18180	55	3	bangladesh	bangladesh	PROPN
bjp-18180	55	4	j	j	PROPN
bjp-18180	55	5	pharmacol	pharmacol	PROPN
bjp-18180	55	6	2014	2014	NUM
bjp-18180	55	7	;	;	PUNCT
bjp-18180	55	8	9	9	NUM
bjp-18180	55	9	:	:	SYM
bjp-18180	55	10	208	208	NUM
bjp-18180	55	11	-	-	SYM
bjp-18180	55	12	217	217	NUM
bjp-18180	55	13	209	209	NUM
bjp-18180	55	14	http://www.ncbi.nlm.nih.gov/protein/	http://www.ncbi.nlm.nih.gov/protein/	NOUN
bjp-18180	55	15	http://www.ncbi.nlm.nih.gov/protein/	http://www.ncbi.nlm.nih.gov/protein/	PROPN
bjp-18180	55	16	http://zhanglab.ccmb.med.umich.edu/lomets/	http://zhanglab.ccmb.med.umich.edu/lomets/	NOUN
bjp-18180	55	17	http://zhanglab.ccmb.med.umich.edu/lomets/	http://zhanglab.ccmb.med.umich.edu/lomets/	NOUN
bjp-18180	55	18	ahead	ahead	ADV
bjp-18180	55	19	all	all	DET
bjp-18180	55	20	water	water	NOUN
bjp-18180	55	21	molecules	molecule	NOUN
bjp-18180	55	22	were	be	AUX
bjp-18180	55	23	removed	remove	VERB
bjp-18180	55	24	from	from	ADP
bjp-18180	55	25	protein	protein	NOUN
bjp-18180	55	26	.	.	PUNCT
bjp-18180	56	1	to	to	PART
bjp-18180	56	2	stabilize	stabilize	VERB
bjp-18180	56	3	the	the	DET
bjp-18180	56	4	charge	charge	NOUN
bjp-18180	56	5	on	on	ADP
bjp-18180	56	6	atom	atom	NOUN
bjp-18180	56	7	appeared	appear	VERB
bjp-18180	56	8	due	due	ADJ
bjp-18180	56	9	to	to	ADP
bjp-18180	56	10	removal	removal	NOUN
bjp-18180	56	11	of	of	ADP
bjp-18180	56	12	water	water	NOUN
bjp-18180	56	13	molecules	molecule	NOUN
bjp-18180	56	14	,	,	PUNCT
bjp-18180	56	15	was	be	AUX
bjp-18180	56	16	compensated	compensate	VERB
bjp-18180	56	17	by	by	ADP
bjp-18180	56	18	addition	addition	NOUN
bjp-18180	56	19	of	of	ADP
bjp-18180	56	20	non	non	ADJ
bjp-18180	56	21	–	–	ADJ
bjp-18180	56	22	polar	polar	ADJ
bjp-18180	56	23	hydrogen	hydrogen	NOUN
bjp-18180	56	24	.	.	PUNCT
bjp-18180	57	1	kollman	kollman	PROPN
bjp-18180	57	2	united	united	PROPN
bjp-18180	57	3	atom	atom	PROPN
bjp-18180	57	4	charges	charge	NOUN
bjp-18180	57	5	and	and	CCONJ
bjp-18180	57	6	gesteiger	gesteiger	NOUN
bjp-18180	57	7	charge	charge	NOUN
bjp-18180	57	8	were	be	AUX
bjp-18180	57	9	assigned	assign	VERB
bjp-18180	57	10	to	to	ADP
bjp-18180	57	11	protein	protein	NOUN
bjp-18180	57	12	and	and	CCONJ
bjp-18180	57	13	ligands	ligand	NOUN
bjp-18180	57	14	respectively	respectively	ADV
bjp-18180	57	15	.	.	PUNCT
bjp-18180	58	1	the	the	DET
bjp-18180	58	2	autodock	autodock	NOUN
bjp-18180	58	3	tools	tool	NOUN
bjp-18180	58	4	package	package	NOUN
bjp-18180	58	5	version	version	NOUN
bjp-18180	58	6	1.5.6	1.5.6	NUM
bjp-18180	58	7	was	be	AUX
bjp-18180	58	8	utilized	utilize	VERB
bjp-18180	58	9	to	to	PART
bjp-18180	58	10	create	create	VERB
bjp-18180	58	11	the	the	DET
bjp-18180	58	12	docking	docking	NOUN
bjp-18180	58	13	input	input	NOUN
bjp-18180	58	14	files	file	NOUN
bjp-18180	58	15	.	.	PUNCT
bjp-18180	59	1	analogue	analogue	NOUN
bjp-18180	59	2	design	design	VERB
bjp-18180	59	3	various	various	ADJ
bjp-18180	59	4	xanthones	xanthone	NOUN
bjp-18180	59	5	and	and	CCONJ
bjp-18180	59	6	their	their	PRON
bjp-18180	59	7	derivatives	derivative	NOUN
bjp-18180	59	8	were	be	AUX
bjp-18180	59	9	known	know	VERB
bjp-18180	59	10	to	to	PART
bjp-18180	59	11	be	be	AUX
bjp-18180	59	12	a	a	DET
bjp-18180	59	13	renounced	renounce	VERB
bjp-18180	59	14	source	source	NOUN
bjp-18180	59	15	for	for	ADP
bjp-18180	59	16	evolving	evolve	VERB
bjp-18180	59	17	a	a	DET
bjp-18180	59	18	potential	potential	ADJ
bjp-18180	59	19	new	new	ADJ
bjp-18180	59	20	anti	anti	ADJ
bjp-18180	59	21	-cancer	-cancer	NOUN
bjp-18180	59	22	candidate	candidate	NOUN
bjp-18180	59	23	.	.	PUNCT
bjp-18180	60	1	several	several	ADJ
bjp-18180	60	2	polyhydroxy	polyhydroxy	ADJ
bjp-18180	60	3	xanthone	xanthone	PROPN
bjp-18180	60	4	derivatives	derivative	NOUN
bjp-18180	60	5	like	like	ADP
bjp-18180	60	6	1,6	1,6	NUM
bjp-18180	60	7	dihydroxy	dihydroxy	NOUN
bjp-18180	60	8	,	,	PUNCT
bjp-18180	60	9	1,3,7	1,3,7	NUM
bjp-18180	60	10	-	-	PUNCT
bjp-18180	60	11	trihydroxy	trihydroxy	ADJ
bjp-18180	60	12	,	,	PUNCT
bjp-18180	60	13	1,3,6,8tetrahydroxy	1,3,6,8tetrahydroxy	NUM
bjp-18180	60	14	substituted	substitute	VERB
bjp-18180	60	15	xan	xan	PROPN
bjp-18180	60	16	-	-	PUNCT
bjp-18180	60	17	thones	thone	NOUN
bjp-18180	60	18	were	be	AUX
bjp-18180	60	19	synthesized	synthesize	VERB
bjp-18180	60	20	and	and	CCONJ
bjp-18180	60	21	were	be	AUX
bjp-18180	60	22	proven	prove	VERB
bjp-18180	60	23	as	as	ADP
bjp-18180	60	24	potential	potential	ADJ
bjp-18180	60	25	anti	anti	ADJ
bjp-18180	60	26	-	-	ADJ
bjp-18180	60	27	cancer	cancer	ADJ
bjp-18180	60	28	targets	target	NOUN
bjp-18180	60	29	.	.	PUNCT
bjp-18180	61	1	trihydroxyl	trihydroxyl	PROPN
bjp-18180	61	2	xanthone	xanthone	PROPN
bjp-18180	61	3	and	and	CCONJ
bjp-18180	61	4	tetrahydroxyl	tetrahydroxyl	PROPN
bjp-18180	61	5	xanthone	xanthone	PROPN
bjp-18180	61	6	were	be	AUX
bjp-18180	61	7	exhibited	exhibit	VERB
bjp-18180	61	8	the	the	DET
bjp-18180	61	9	highest	high	ADJ
bjp-18180	61	10	cytotoxic	cytotoxic	ADJ
bjp-18180	61	11	activities	activity	NOUN
bjp-18180	61	12	during	during	ADP
bjp-18180	61	13	cell	cell	NOUN
bjp-18180	61	14	line	line	NOUN
bjp-18180	61	15	studies	study	NOUN
bjp-18180	61	16	.	.	PUNCT
bjp-18180	62	1	but	but	CCONJ
bjp-18180	62	2	it	it	PRON
bjp-18180	62	3	was	be	AUX
bjp-18180	62	4	found	find	VERB
bjp-18180	62	5	that	that	SCONJ
bjp-18180	62	6	the	the	DET
bjp-18180	62	7	activity	activity	NOUN
bjp-18180	62	8	of	of	ADP
bjp-18180	62	9	these	these	DET
bjp-18180	62	10	xanthones	xanthone	NOUN
bjp-18180	62	11	does	do	AUX
bjp-18180	62	12	not	not	PART
bjp-18180	62	13	increase	increase	VERB
bjp-18180	62	14	linearly	linearly	ADV
bjp-18180	62	15	with	with	ADP
bjp-18180	62	16	the	the	DET
bjp-18180	62	17	increasing	increase	VERB
bjp-18180	62	18	number	number	NOUN
bjp-18180	62	19	of	of	ADP
bjp-18180	62	20	hydroxyl	hydroxyl	NOUN
bjp-18180	62	21	groups	group	NOUN
bjp-18180	62	22	,	,	PUNCT
bjp-18180	62	23	suggesting	suggest	VERB
bjp-18180	62	24	that	that	SCONJ
bjp-18180	62	25	the	the	DET
bjp-18180	62	26	position	position	NOUN
bjp-18180	62	27	and	and	CCONJ
bjp-18180	62	28	substitutions	substitution	NOUN
bjp-18180	62	29	on	on	ADP
bjp-18180	62	30	hydroxyl	hydroxyl	PROPN
bjp-18180	62	31	group	group	NOUN
bjp-18180	62	32	also	also	ADV
bjp-18180	62	33	has	have	VERB
bjp-18180	62	34	an	an	DET
bjp-18180	62	35	obvious	obvious	ADJ
bjp-18180	62	36	effect	effect	NOUN
bjp-18180	62	37	on	on	ADP
bjp-18180	62	38	the	the	DET
bjp-18180	62	39	inhibitory	inhibitory	ADJ
bjp-18180	62	40	activities	activity	NOUN
bjp-18180	62	41	of	of	ADP
bjp-18180	62	42	the	the	DET
bjp-18180	62	43	compounds	compound	NOUN
bjp-18180	62	44	(	(	PUNCT
bjp-18180	62	45	su	su	PROPN
bjp-18180	62	46	et	et	PROPN
bjp-18180	62	47	al	al	PROPN
bjp-18180	62	48	.	.	PROPN
bjp-18180	62	49	,	,	PUNCT
bjp-18180	62	50	2011	2011	NUM
bjp-18180	62	51	)	)	PUNCT
bjp-18180	62	52	.	.	PUNCT
bjp-18180	63	1	the	the	DET
bjp-18180	63	2	alkoxy	alkoxy	ADJ
bjp-18180	63	3	derivatives	derivative	NOUN
bjp-18180	63	4	of	of	ADP
bjp-18180	63	5	xanthones	xanthone	NOUN
bjp-18180	63	6	revealed	reveal	VERB
bjp-18180	63	7	that	that	SCONJ
bjp-18180	63	8	they	they	PRON
bjp-18180	63	9	also	also	ADV
bjp-18180	63	10	possess	possess	VERB
bjp-18180	63	11	tremendous	tremendous	ADJ
bjp-18180	63	12	power	power	NOUN
bjp-18180	63	13	against	against	ADP
bjp-18180	63	14	cancer	cancer	NOUN
bjp-18180	63	15	.	.	PUNCT
bjp-18180	64	1	thiosemicarbazones	thiosemicarbazone	NOUN
bjp-18180	64	2	,	,	PUNCT
bjp-18180	64	3	nitrosoureas	nitrosourea	NOUN
bjp-18180	64	4	,	,	PUNCT
bjp-18180	64	5	thiourea	thiourea	NOUN
bjp-18180	64	6	,	,	PUNCT
bjp-18180	64	7	triazoles	triazole	NOUN
bjp-18180	64	8	derivatives	derivative	NOUN
bjp-18180	64	9	also	also	ADV
bjp-18180	64	10	possess	possess	VERB
bjp-18180	64	11	a	a	DET
bjp-18180	64	12	long	long	ADJ
bjp-18180	64	13	history	history	NOUN
bjp-18180	64	14	in	in	ADP
bjp-18180	64	15	the	the	DET
bjp-18180	64	16	development	development	NOUN
bjp-18180	64	17	of	of	ADP
bjp-18180	64	18	anti	anti	ADJ
bjp-18180	64	19	-	-	ADJ
bjp-18180	64	20	cancer	cancer	ADJ
bjp-18180	64	21	drug	drug	NOUN
bjp-18180	64	22	candidates	candidate	NOUN
bjp-18180	64	23	(	(	PUNCT
bjp-18180	64	24	bailly	bailly	ADV
bjp-18180	64	25	,	,	PUNCT
bjp-18180	64	26	2012	2012	NUM
bjp-18180	64	27	)	)	PUNCT
bjp-18180	64	28	.	.	PUNCT
bjp-18180	65	1	thus	thus	ADV
bjp-18180	65	2	,	,	PUNCT
bjp-18180	65	3	11	11	NUM
bjp-18180	65	4	hybrid	hybrid	ADJ
bjp-18180	65	5	xanthones	xanthone	NOUN
bjp-18180	65	6	were	be	AUX
bjp-18180	65	7	designed	design	VERB
bjp-18180	65	8	,	,	PUNCT
bjp-18180	65	9	considering	consider	VERB
bjp-18180	65	10	key	key	ADJ
bjp-18180	65	11	information	information	NOUN
bjp-18180	65	12	obtain	obtain	VERB
bjp-18180	65	13	from	from	ADP
bjp-18180	65	14	previous	previous	ADJ
bjp-18180	65	15	work	work	NOUN
bjp-18180	65	16	published	publish	VERB
bjp-18180	65	17	by	by	ADP
bjp-18180	65	18	various	various	ADJ
bjp-18180	65	19	researchers	researcher	NOUN
bjp-18180	65	20	in	in	ADP
bjp-18180	65	21	this	this	DET
bjp-18180	65	22	field	field	NOUN
bjp-18180	65	23	.	.	PUNCT
bjp-18180	66	1	therefore	therefore	ADV
bjp-18180	66	2	,	,	PUNCT
bjp-18180	66	3	all	all	DET
bjp-18180	66	4	structures	structure	NOUN
bjp-18180	66	5	are	be	AUX
bjp-18180	66	6	hybrid	hybrid	ADJ
bjp-18180	66	7	alkoxy	alkoxy	ADJ
bjp-18180	66	8	derivatives	derivative	NOUN
bjp-18180	66	9	of	of	ADP
bjp-18180	66	10	xanthones	xanthone	NOUN
bjp-18180	66	11	possessing	possess	VERB
bjp-18180	66	12	different	different	ADJ
bjp-18180	66	13	substituents	substituent	NOUN
bjp-18180	66	14	as	as	ADP
bjp-18180	66	15	side	side	NOUN
bjp-18180	66	16	chain	chain	NOUN
bjp-18180	66	17	.	.	PUNCT
bjp-18180	67	1	ligand	ligand	ADJ
bjp-18180	67	2	structure	structure	NOUN
bjp-18180	67	3	preparation	preparation	NOUN
bjp-18180	67	4	,	,	PUNCT
bjp-18180	67	5	toxicity	toxicity	NOUN
bjp-18180	67	6	and	and	CCONJ
bjp-18180	67	7	drug	drug	NOUN
bjp-18180	67	8	likeness	likeness	NOUN
bjp-18180	68	1	the	the	DET
bjp-18180	68	2	data	datum	NOUN
bjp-18180	68	3	set	set	VERB
bjp-18180	68	4	of	of	ADP
bjp-18180	68	5	different	different	ADJ
bjp-18180	68	6	hybrid	hybrid	ADJ
bjp-18180	68	7	xanthones	xanthone	NOUN
bjp-18180	68	8	having	having	AUX
bjp-18180	68	9	differ	differ	VERB
bjp-18180	68	10	--rent	--rent	PUNCT
bjp-18180	68	11	xanthone	xanthone	PROPN
bjp-18180	68	12	nucleus	nucleus	PROPN
bjp-18180	68	13	,	,	PUNCT
bjp-18180	68	14	dihydroxyl	dihydroxyl	PROPN
bjp-18180	68	15	xanthone	xanthone	PROPN
bjp-18180	68	16	,	,	PUNCT
bjp-18180	68	17	trihydroxyl	trihydroxyl	PROPN
bjp-18180	68	18	xanthone	xanthone	PROPN
bjp-18180	68	19	,	,	PUNCT
bjp-18180	68	20	thioxanthone	thioxanthone	NOUN
bjp-18180	68	21	nucleus	nucleus	NOUN
bjp-18180	68	22	were	be	AUX
bjp-18180	68	23	generated	generate	VERB
bjp-18180	68	24	ligand	ligand	ADJ
bjp-18180	68	25	molecules	molecule	NOUN
bjp-18180	68	26	.	.	PUNCT
bjp-18180	69	1	chemaxon	chemaxon	PROPN
bjp-18180	69	2	,	,	PUNCT
bjp-18180	69	3	freeware	freeware	PROPN
bjp-18180	69	4	developed	develop	VERB
bjp-18180	69	5	by	by	ADP
bjp-18180	69	6	advanced	advanced	ADJ
bjp-18180	69	7	chemistry	chemistry	NOUN
bjp-18180	69	8	development	development	NOUN
bjp-18180	69	9	,	,	PUNCT
bjp-18180	69	10	inc	inc	PROPN
bjp-18180	69	11	.	.	PROPN
bjp-18180	69	12	was	be	AUX
bjp-18180	69	13	used	use	VERB
bjp-18180	69	14	for	for	ADP
bjp-18180	69	15	drawing	draw	VERB
bjp-18180	69	16	and	and	CCONJ
bjp-18180	69	17	converting	convert	VERB
bjp-18180	69	18	2d	2d	NUM
bjp-18180	69	19	chemical	chemical	NOUN
bjp-18180	69	20	structure	structure	NOUN
bjp-18180	69	21	of	of	ADP
bjp-18180	69	22	compound	compound	NOUN
bjp-18180	69	23	to	to	ADP
bjp-18180	69	24	3d	3d	NUM
bjp-18180	69	25	structures	structure	NOUN
bjp-18180	69	26	.	.	PUNCT
bjp-18180	70	1	all	all	DET
bjp-18180	70	2	3d	3d	NUM
bjp-18180	70	3	structures	structure	NOUN
bjp-18180	70	4	were	be	AUX
bjp-18180	70	5	optimized	optimize	VERB
bjp-18180	70	6	through	through	ADP
bjp-18180	70	7	chemaxon	chemaxon	PROPN
bjp-18180	70	8	.	.	PUNCT
bjp-18180	71	1	medchem	medchem	PROPN
bjp-18180	71	2	designer	designer	NOUN
bjp-18180	71	3	was	be	AUX
bjp-18180	71	4	used	use	VERB
bjp-18180	71	5	for	for	ADP
bjp-18180	71	6	adme	adme	NOUN
bjp-18180	71	7	/	/	SYM
bjp-18180	71	8	tox	tox	NOUN
bjp-18180	71	9	screening	screening	NOUN
bjp-18180	71	10	of	of	ADP
bjp-18180	71	11	the	the	DET
bjp-18180	71	12	selected	select	VERB
bjp-18180	71	13	ligands	ligand	NOUN
bjp-18180	71	14	and	and	CCONJ
bjp-18180	71	15	the	the	DET
bjp-18180	71	16	results	result	NOUN
bjp-18180	71	17	were	be	AUX
bjp-18180	71	18	recorded	record	VERB
bjp-18180	71	19	.	.	PUNCT
bjp-18180	72	1	in	in	ADP
bjp-18180	72	2	silico	silico	NOUN
bjp-18180	72	3	prediction	prediction	NOUN
bjp-18180	72	4	biological	biological	ADJ
bjp-18180	72	5	activity	activity	NOUN
bjp-18180	72	6	of	of	ADP
bjp-18180	72	7	the	the	DET
bjp-18180	72	8	compounds	compound	NOUN
bjp-18180	72	9	were	be	AUX
bjp-18180	72	10	calculated	calculate	VERB
bjp-18180	72	11	such	such	ADJ
bjp-18180	72	12	as	as	ADP
bjp-18180	72	13	molecular	molecular	ADJ
bjp-18180	72	14	weight	weight	NOUN
bjp-18180	72	15	,	,	PUNCT
bjp-18180	72	16	hydrogen	hydrogen	NOUN
bjp-18180	72	17	bond	bond	NOUN
bjp-18180	72	18	donors	donor	NOUN
bjp-18180	72	19	/	/	SYM
bjp-18180	72	20	acceptors	acceptor	NOUN
bjp-18180	72	21	,	,	PUNCT
bjp-18180	72	22	logp	logp	NOUN
bjp-18180	72	23	and	and	CCONJ
bjp-18180	72	24	total	total	ADJ
bjp-18180	72	25	polar	polar	ADJ
bjp-18180	72	26	surface	surface	NOUN
bjp-18180	72	27	area	area	NOUN
bjp-18180	72	28	(	(	PUNCT
bjp-18180	72	29	tpsa	tpsa	PROPN
bjp-18180	72	30	)	)	PUNCT
bjp-18180	72	31	.	.	PUNCT
bjp-18180	73	1	actelion	actelion	NOUN
bjp-18180	73	2	(	(	PUNCT
bjp-18180	73	3	osiris	osiris	PROPN
bjp-18180	73	4	)	)	PUNCT
bjp-18180	73	5	property	property	NOUN
bjp-18180	73	6	explorer	explorer	NOUN
bjp-18180	73	7	(	(	PUNCT
bjp-18180	73	8	shen	shen	PROPN
bjp-18180	73	9	et	et	PROPN
bjp-18180	73	10	al	al	PROPN
bjp-18180	73	11	.	.	PROPN
bjp-18180	73	12	,	,	PUNCT
bjp-18180	73	13	2010	2010	NUM
bjp-18180	73	14	)	)	PUNCT
bjp-18180	73	15	was	be	AUX
bjp-18180	73	16	used	use	VERB
bjp-18180	73	17	to	to	PART
bjp-18180	73	18	screen	screen	VERB
bjp-18180	73	19	the	the	DET
bjp-18180	73	20	drug	drug	NOUN
bjp-18180	73	21	likeness	likeness	NOUN
bjp-18180	73	22	.	.	PUNCT
bjp-18180	74	1	toxicity	toxicity	NOUN
bjp-18180	74	2	risks	risk	NOUN
bjp-18180	74	3	were	be	AUX
bjp-18180	74	4	evaluated	evaluate	VERB
bjp-18180	74	5	by	by	ADP
bjp-18180	74	6	calculating	calculate	VERB
bjp-18180	74	7	mutagenic	mutagenic	ADJ
bjp-18180	74	8	,	,	PUNCT
bjp-18180	74	9	tumorigenic	tumorigenic	NOUN
bjp-18180	74	10	,	,	PUNCT
bjp-18180	74	11	irritant	irritant	ADJ
bjp-18180	74	12	,	,	PUNCT
bjp-18180	74	13	reproductive	reproductive	ADJ
bjp-18180	74	14	effective	effective	ADJ
bjp-18180	74	15	,	,	PUNCT
bjp-18180	74	16	solubility	solubility	NOUN
bjp-18180	74	17	,	,	PUNCT
bjp-18180	74	18	drug	drug	NOUN
bjp-18180	74	19	likeliness	likeliness	NOUN
bjp-18180	74	20	and	and	CCONJ
bjp-18180	74	21	drug	drug	NOUN
bjp-18180	74	22	score	score	NOUN
bjp-18180	74	23	.	.	PUNCT
bjp-18180	75	1	molecular	molecular	ADJ
bjp-18180	75	2	docking	docking	NOUN
bjp-18180	75	3	simulations	simulation	VERB
bjp-18180	75	4	the	the	DET
bjp-18180	75	5	autodock	autodock	NOUN
bjp-18180	75	6	tools	tool	NOUN
bjp-18180	75	7	package	package	NOUN
bjp-18180	75	8	version	version	NOUN
bjp-18180	75	9	1.5.6	1.5.6	NUM
bjp-18180	75	10	was	be	AUX
bjp-18180	75	11	utilized	utilize	VERB
bjp-18180	75	12	to	to	PART
bjp-18180	75	13	create	create	VERB
bjp-18180	75	14	the	the	DET
bjp-18180	75	15	docking	docking	NOUN
bjp-18180	75	16	input	input	NOUN
bjp-18180	75	17	files	file	NOUN
bjp-18180	75	18	.	.	PUNCT
bjp-18180	76	1	the	the	DET
bjp-18180	76	2	grids	grid	NOUN
bjp-18180	76	3	were	be	AUX
bjp-18180	76	4	chosen	choose	VERB
bjp-18180	76	5	to	to	PART
bjp-18180	76	6	be	be	AUX
bjp-18180	76	7	sufficiently	sufficiently	ADV
bjp-18180	76	8	large	large	ADJ
bjp-18180	76	9	so	so	SCONJ
bjp-18180	76	10	as	as	SCONJ
bjp-18180	76	11	to	to	PART
bjp-18180	76	12	include	include	VERB
bjp-18180	76	13	not	not	PART
bjp-18180	76	14	only	only	ADV
bjp-18180	76	15	the	the	DET
bjp-18180	76	16	active	active	ADJ
bjp-18180	76	17	site	site	NOUN
bjp-18180	76	18	residues	residue	NOUN
bjp-18180	76	19	but	but	CCONJ
bjp-18180	76	20	also	also	ADV
bjp-18180	76	21	significant	significant	ADJ
bjp-18180	76	22	portion	portion	NOUN
bjp-18180	76	23	of	of	ADP
bjp-18180	76	24	the	the	DET
bjp-18180	76	25	surrounding	surround	VERB
bjp-18180	76	26	surface	surface	NOUN
bjp-18180	76	27	of	of	ADP
bjp-18180	76	28	the	the	DET
bjp-18180	76	29	receptor	receptor	NOUN
bjp-18180	76	30	protein	protein	NOUN
bjp-18180	76	31	,	,	PUNCT
bjp-18180	76	32	with	with	ADP
bjp-18180	76	33	grid	grid	NOUN
bjp-18180	76	34	points	point	NOUN
bjp-18180	76	35	80	80	NUM
bjp-18180	76	36	×	×	NOUN
bjp-18180	76	37	80	80	NUM
bjp-18180	76	38	×	×	NOUN
bjp-18180	76	39	80	80	NUM
bjp-18180	76	40	along	along	ADP
bjp-18180	76	41	with	with	ADP
bjp-18180	76	42	grid	grid	NOUN
bjp-18180	76	43	spacing	spacing	NOUN
bjp-18180	76	44	of	of	ADP
bjp-18180	76	45	0.531a	0.531a	NOUN
bjp-18180	76	46	.	.	PUNCT
bjp-18180	77	1	in	in	ADP
bjp-18180	77	2	grid	grid	NOUN
bjp-18180	77	3	based	base	VERB
bjp-18180	77	4	ligand	ligand	NOUN
bjp-18180	77	5	docking	docking	NOUN
bjp-18180	77	6	,	,	PUNCT
bjp-18180	77	7	taking	take	VERB
bjp-18180	77	8	energetically	energetically	ADV
bjp-18180	77	9	favorable	favorable	ADJ
bjp-18180	77	10	interactions	interaction	NOUN
bjp-18180	77	11	between	between	ADP
bjp-18180	77	12	small	small	ADJ
bjp-18180	77	13	ligand	ligand	NOUN
bjp-18180	77	14	and	and	CCONJ
bjp-18180	77	15	typically	typically	ADV
bjp-18180	77	16	a	a	DET
bjp-18180	77	17	larger	large	ADJ
bjp-18180	77	18	receptor	receptor	NOUN
bjp-18180	77	19	molecule	molecule	NOUN
bjp-18180	77	20	,	,	PUNCT
bjp-18180	77	21	generally	generally	ADV
bjp-18180	77	22	a	a	DET
bjp-18180	77	23	protein	protein	NOUN
bjp-18180	77	24	is	be	AUX
bjp-18180	77	25	analyzed	analyze	VERB
bjp-18180	77	26	.	.	PUNCT
bjp-18180	78	1	for	for	ADP
bjp-18180	78	2	refinement	refinement	NOUN
bjp-18180	78	3	of	of	ADP
bjp-18180	78	4	docking	docking	NOUN
bjp-18180	78	5	solutions	solution	NOUN
bjp-18180	78	6	,	,	PUNCT
bjp-18180	78	7	in	in	ADP
bjp-18180	78	8	a	a	DET
bjp-18180	78	9	grid	grid	NOUN
bjp-18180	78	10	-	-	PUNCT
bjp-18180	78	11	based	base	VERB
bjp-18180	78	12	force	force	NOUN
bjp-18180	78	13	field	field	NOUN
bjp-18180	78	14	evaluation	evaluation	NOUN
bjp-18180	78	15	,	,	PUNCT
bjp-18180	78	16	torsional	torsional	ADJ
bjp-18180	78	17	and	and	CCONJ
bjp-18180	78	18	rigid	rigid	ADJ
bjp-18180	78	19	body	body	NOUN
bjp-18180	78	20	movements	movement	NOUN
bjp-18180	78	21	of	of	ADP
bjp-18180	78	22	ligand	ligand	NOUN
bjp-18180	78	23	is	be	AUX
bjp-18180	78	24	quantified	quantify	VERB
bjp-18180	78	25	.	.	PUNCT
bjp-18180	79	1	genetic	genetic	ADJ
bjp-18180	79	2	algorithm	algorithm	NOUN
bjp-18180	79	3	is	be	AUX
bjp-18180	79	4	employed	employ	VERB
bjp-18180	79	5	as	as	ADP
bjp-18180	79	6	a	a	DET
bjp-18180	79	7	search	search	NOUN
bjp-18180	79	8	parameter	parameter	NOUN
bjp-18180	79	9	for	for	ADP
bjp-18180	79	10	docking	docking	NOUN
bjp-18180	79	11	.	.	PUNCT
bjp-18180	80	1	lamarckian	lamarckian	ADJ
bjp-18180	80	2	genetic	genetic	ADJ
bjp-18180	80	3	algorithm	algorithm	NOUN
bjp-18180	80	4	(	(	PUNCT
bjp-18180	80	5	lga	lga	NOUN
bjp-18180	80	6	)	)	PUNCT
bjp-18180	80	7	which	which	PRON
bjp-18180	80	8	is	be	AUX
bjp-18180	80	9	a	a	DET
bjp-18180	80	10	hybrid	hybrid	NOUN
bjp-18180	80	11	of	of	ADP
bjp-18180	80	12	a	a	DET
bjp-18180	80	13	genetic	genetic	ADJ
bjp-18180	80	14	algorithm	algorithm	NOUN
bjp-18180	80	15	and	and	CCONJ
bjp-18180	80	16	a	a	DET
bjp-18180	80	17	local	local	ADJ
bjp-18180	80	18	search	search	NOUN
bjp-18180	80	19	algorithm	algorithm	NOUN
bjp-18180	80	20	,	,	PUNCT
bjp-18180	80	21	were	be	AUX
bjp-18180	80	22	used	use	VERB
bjp-18180	80	23	for	for	ADP
bjp-18180	80	24	ligand	ligand	ADJ
bjp-18180	80	25	conformational	conformational	ADJ
bjp-18180	80	26	searching	searching	NOUN
bjp-18180	80	27	.	.	PUNCT
bjp-18180	81	1	rigid	rigid	ADJ
bjp-18180	81	2	roots	root	NOUN
bjp-18180	81	3	were	be	AUX
bjp-18180	81	4	given	give	VERB
bjp-18180	81	5	to	to	ADP
bjp-18180	81	6	the	the	DET
bjp-18180	81	7	ligand	ligand	NOUN
bjp-18180	81	8	with	with	ADP
bjp-18180	81	9	five	five	NUM
bjp-18180	81	10	rotatable	rotatable	ADJ
bjp-18180	81	11	bonds	bond	NOUN
bjp-18180	81	12	.	.	PUNCT
bjp-18180	82	1	pre	pre	VERB
bjp-18180	82	2	-	-	ADJ
bjp-18180	82	3	calculated	calculated	ADJ
bjp-18180	82	4	grid	grid	NOUN
bjp-18180	82	5	maps	map	NOUN
bjp-18180	82	6	was	be	AUX
bjp-18180	82	7	obtained	obtain	VERB
bjp-18180	82	8	by	by	ADP
bjp-18180	82	9	using	use	VERB
bjp-18180	82	10	autogrid	autogrid	NOUN
bjp-18180	82	11	.	.	PUNCT
bjp-18180	83	1	as	as	ADP
bjp-18180	83	2	after	after	ADP
bjp-18180	83	3	completion	completion	NOUN
bjp-18180	83	4	of	of	ADP
bjp-18180	83	5	docking	docking	NOUN
bjp-18180	83	6	,	,	PUNCT
bjp-18180	83	7	the	the	DET
bjp-18180	83	8	conformation	conformation	NOUN
bjp-18180	83	9	of	of	ADP
bjp-18180	83	10	ligand	ligand	NOUN
bjp-18180	83	11	which	which	PRON
bjp-18180	83	12	shows	show	VERB
bjp-18180	83	13	maximum	maximum	ADJ
bjp-18180	83	14	lowest	low	ADJ
bjp-18180	83	15	docked	docked	ADJ
bjp-18180	83	16	energy	energy	NOUN
bjp-18180	83	17	(	(	PUNCT
bjp-18180	83	18	binding	bind	VERB
bjp-18180	83	19	energy	energy	NOUN
bjp-18180	83	20	)	)	PUNCT
bjp-18180	83	21	was	be	AUX
bjp-18180	83	22	chosen	choose	VERB
bjp-18180	83	23	.	.	PUNCT
bjp-18180	84	1	this	this	DET
bjp-18180	84	2	procedure	procedure	NOUN
bjp-18180	84	3	was	be	AUX
bjp-18180	84	4	applied	apply	VERB
bjp-18180	84	5	to	to	ADP
bjp-18180	84	6	all	all	DET
bjp-18180	84	7	ligands	ligand	NOUN
bjp-18180	84	8	.	.	PUNCT
bjp-18180	85	1	selected	select	VERB
bjp-18180	85	2	favorable	favorable	ADJ
bjp-18180	85	3	conformations	conformation	NOUN
bjp-18180	85	4	were	be	AUX
bjp-18180	85	5	analyzed	analyze	VERB
bjp-18180	85	6	using	use	VERB
bjp-18180	85	7	pymol	pymol	PROPN
bjp-18180	85	8	software	software	NOUN
bjp-18180	85	9	.	.	PUNCT
bjp-18180	86	1	results	result	VERB
bjp-18180	86	2	sequence	sequence	NOUN
bjp-18180	86	3	alignment	alignment	NOUN
bjp-18180	86	4	of	of	ADP
bjp-18180	86	5	target	target	NOUN
bjp-18180	86	6	and	and	CCONJ
bjp-18180	86	7	template	template	NOUN
bjp-18180	86	8	sequences	sequence	NOUN
bjp-18180	86	9	was	be	AUX
bjp-18180	86	10	performed	perform	VERB
bjp-18180	86	11	to	to	PART
bjp-18180	86	12	estimate	estimate	VERB
bjp-18180	86	13	the	the	DET
bjp-18180	86	14	matches	match	NOUN
bjp-18180	86	15	and	and	CCONJ
bjp-18180	86	16	similarity	similarity	NOUN
bjp-18180	86	17	score	score	NOUN
bjp-18180	86	18	by	by	ADP
bjp-18180	86	19	using	use	VERB
bjp-18180	86	20	clustal	clustal	PROPN
bjp-18180	86	21	w	w	PROPN
bjp-18180	86	22	and	and	CCONJ
bjp-18180	86	23	t	t	PROPN
bjp-18180	86	24	-	-	PUNCT
bjp-18180	86	25	coffee	coffee	NOUN
bjp-18180	86	26	.	.	PUNCT
bjp-18180	87	1	the	the	DET
bjp-18180	87	2	similarity	similarity	NOUN
bjp-18180	87	3	scores	score	NOUN
bjp-18180	87	4	were	be	AUX
bjp-18180	87	5	calculated	calculate	VERB
bjp-18180	87	6	to	to	PART
bjp-18180	87	7	be	be	AUX
bjp-18180	87	8	65	65	NUM
bjp-18180	87	9	%	%	NOUN
bjp-18180	87	10	,	,	PUNCT
bjp-18180	87	11	however	however	ADV
bjp-18180	87	12	the	the	DET
bjp-18180	87	13	identities	identity	NOUN
bjp-18180	87	14	are	be	AUX
bjp-18180	87	15	estimated	estimate	VERB
bjp-18180	87	16	to	to	ADP
bjp-18180	87	17	48	48	NUM
bjp-18180	87	18	%	%	NOUN
bjp-18180	87	19	(	(	PUNCT
bjp-18180	87	20	figure	figure	NOUN
bjp-18180	87	21	1	1	NUM
bjp-18180	87	22	)	)	PUNCT
bjp-18180	87	23	.	.	PUNCT
bjp-18180	88	1	the	the	DET
bjp-18180	88	2	structural	structural	ADJ
bjp-18180	88	3	assessment	assessment	NOUN
bjp-18180	88	4	results	result	NOUN
bjp-18180	88	5	were	be	AUX
bjp-18180	88	6	obtained	obtain	VERB
bjp-18180	88	7	to	to	PART
bjp-18180	88	8	be	be	AUX
bjp-18180	88	9	85	85	NUM
bjp-18180	88	10	%	%	NOUN
bjp-18180	88	11	(	(	PUNCT
bjp-18180	88	12	procheck	procheck	NOUN
bjp-18180	88	13	)	)	PUNCT
bjp-18180	88	14	(	(	PUNCT
bjp-18180	88	15	figure	figure	NOUN
bjp-18180	88	16	2	2	NUM
bjp-18180	88	17	)	)	PUNCT
bjp-18180	88	18	,	,	PUNCT
bjp-18180	88	19	86.6	86.6	NUM
bjp-18180	88	20	(	(	PUNCT
bjp-18180	88	21	errat	errat	X
bjp-18180	88	22	overall	overall	ADJ
bjp-18180	88	23	quality	quality	NOUN
bjp-18180	88	24	factor	factor	NOUN
bjp-18180	88	25	)	)	PUNCT
bjp-18180	88	26	and	and	CCONJ
bjp-18180	89	1	0.7	0.7	NUM
bjp-18180	89	2	(	(	PUNCT
bjp-18180	89	3	verify3d	verify3d	NOUN
bjp-18180	89	4	)	)	PUNCT
bjp-18180	89	5	for	for	ADP
bjp-18180	89	6	a	a	DET
bjp-18180	89	7	broad	broad	ADJ
bjp-18180	89	8	study	study	NOUN
bjp-18180	89	9	of	of	ADP
bjp-18180	89	10	the	the	DET
bjp-18180	89	11	proteins	protein	NOUN
bjp-18180	89	12	.	.	PUNCT
bjp-18180	90	1	further	further	ADJ
bjp-18180	90	2	modeval	modeval	NOUN
bjp-18180	90	3	was	be	AUX
bjp-18180	90	4	shown	show	VERB
bjp-18180	90	5	excellent	excellent	ADJ
bjp-18180	90	6	quality	quality	NOUN
bjp-18180	90	7	of	of	ADP
bjp-18180	90	8	the	the	DET
bjp-18180	90	9	model	model	NOUN
bjp-18180	90	10	.	.	PUNCT
bjp-18180	91	1	the	the	DET
bjp-18180	91	2	results	result	NOUN
bjp-18180	91	3	were	be	AUX
bjp-18180	91	4	found	find	VERB
bjp-18180	91	5	to	to	PART
bjp-18180	91	6	be	be	AUX
bjp-18180	91	7	rmsd	rmsd	X
bjp-18180	91	8	(	(	PUNCT
bjp-18180	91	9	2.7	2.7	NUM
bjp-18180	91	10	)	)	PUNCT
bjp-18180	91	11	,	,	PUNCT
bjp-18180	91	12	native	native	ADJ
bjp-18180	91	13	overlap	overlap	NOUN
bjp-18180	91	14	(	(	PUNCT
bjp-18180	91	15	0.9	0.9	NUM
bjp-18180	91	16	)	)	PUNCT
bjp-18180	91	17	,	,	PUNCT
bjp-18180	91	18	z	z	NOUN
bjp-18180	91	19	-	-	PUNCT
bjp-18180	91	20	dope	dope	NOUN
bjp-18180	91	21	(	(	PUNCT
bjp-18180	91	22	-1.2	-1.2	NOUN
bjp-18180	91	23	)	)	PUNCT
bjp-18180	91	24	,	,	PUNCT
bjp-18180	91	25	z	z	NOUN
bjp-18180	91	26	-	-	PUNCT
bjp-18180	91	27	pair	pair	NOUN
bjp-18180	91	28	(	(	PUNCT
bjp-18180	91	29	-14.1	-14.1	ADJ
bjp-18180	91	30	)	)	PUNCT
bjp-18180	91	31	,	,	PUNCT
bjp-18180	91	32	z	z	NOUN
bjp-18180	91	33	-	-	PUNCT
bjp-18180	91	34	surf	surf	NOUN
bjp-18180	91	35	(	(	PUNCT
bjp-18180	91	36	-10.9	-10.9	NOUN
bjp-18180	91	37	)	)	PUNCT
bjp-18180	91	38	,	,	PUNCT
bjp-18180	91	39	z	z	NOUN
bjp-18180	91	40	-	-	PUNCT
bjp-18180	91	41	combi	combi	PROPN
bjp-18180	91	42	(	(	PUNCT
bjp-18180	91	43	-18.3	-18.3	NUM
bjp-18180	91	44	)	)	PUNCT
bjp-18180	91	45	.	.	PUNCT
bjp-18180	92	1	the	the	DET
bjp-18180	92	2	different	different	ADJ
bjp-18180	92	3	xanthone	xanthone	PROPN
bjp-18180	92	4	groups	group	NOUN
bjp-18180	92	5	were	be	AUX
bjp-18180	92	6	added	add	VERB
bjp-18180	92	7	(	(	PUNCT
bjp-18180	92	8	table	table	NOUN
bjp-18180	92	9	i	i	NOUN
bjp-18180	92	10	)	)	PUNCT
bjp-18180	92	11	.	.	PUNCT
bjp-18180	93	1	results	result	NOUN
bjp-18180	93	2	obtained	obtain	VERB
bjp-18180	93	3	on	on	ADP
bjp-18180	93	4	docking	docking	NOUN
bjp-18180	93	5	,	,	PUNCT
bjp-18180	93	6	shows	show	VERB
bjp-18180	93	7	that	that	SCONJ
bjp-18180	93	8	the	the	DET
bjp-18180	93	9	length	length	NOUN
bjp-18180	93	10	of	of	ADP
bjp-18180	93	11	alkyl	alkyl	ADJ
bjp-18180	93	12	chains	chain	NOUN
bjp-18180	93	13	greatly	greatly	ADV
bjp-18180	93	14	affects	affect	VERB
bjp-18180	93	15	the	the	DET
bjp-18180	93	16	binding	bind	VERB
bjp-18180	93	17	results	result	NOUN
bjp-18180	93	18	.	.	PUNCT
bjp-18180	94	1	the	the	DET
bjp-18180	94	2	propyl	propyl	NOUN
bjp-18180	94	3	chain	chain	NOUN
bjp-18180	94	4	was	be	AUX
bjp-18180	94	5	found	find	VERB
bjp-18180	94	6	to	to	PART
bjp-18180	94	7	be	be	AUX
bjp-18180	94	8	best	good	ADJ
bjp-18180	94	9	for	for	ADP
bjp-18180	94	10	giving	give	VERB
bjp-18180	94	11	maximum	maximum	ADJ
bjp-18180	94	12	interaction	interaction	NOUN
bjp-18180	94	13	with	with	ADP
bjp-18180	94	14	residues	residue	NOUN
bjp-18180	94	15	present	present	ADJ
bjp-18180	94	16	inside	inside	ADP
bjp-18180	94	17	the	the	DET
bjp-18180	94	18	binding	bind	VERB
bjp-18180	94	19	pocket	pocket	NOUN
bjp-18180	94	20	.	.	PUNCT
bjp-18180	95	1	the	the	DET
bjp-18180	95	2	carbon	carbon	NOUN
bjp-18180	95	3	atom	atom	NOUN
bjp-18180	95	4	of	of	ADP
bjp-18180	95	5	alkyl	alkyl	PROPN
bjp-18180	95	6	chain	chain	NOUN
bjp-18180	95	7	interacts	interact	VERB
bjp-18180	95	8	through	through	ADP
bjp-18180	95	9	hydrophobic	hydrophobic	NOUN
bjp-18180	95	10	interactions	interaction	NOUN
bjp-18180	95	11	.	.	PUNCT
bjp-18180	96	1	presence	presence	NOUN
bjp-18180	96	2	of	of	ADP
bjp-18180	96	3	primary	primary	ADJ
bjp-18180	96	4	as	as	ADV
bjp-18180	96	5	well	well	ADV
bjp-18180	96	6	as	as	ADP
bjp-18180	96	7	secondary	secondary	ADJ
bjp-18180	96	8	nitrogen	nitrogen	NOUN
bjp-18180	96	9	in	in	ADP
bjp-18180	96	10	chemical	chemical	NOUN
bjp-18180	96	11	structure	structure	NOUN
bjp-18180	96	12	found	find	VERB
bjp-18180	96	13	to	to	PART
bjp-18180	96	14	be	be	AUX
bjp-18180	96	15	essential	essential	ADJ
bjp-18180	96	16	to	to	PART
bjp-18180	96	17	interact	interact	VERB
bjp-18180	96	18	more	more	ADV
bjp-18180	96	19	with	with	ADP
bjp-18180	96	20	residues	residue	NOUN
bjp-18180	96	21	via	via	ADP
bjp-18180	96	22	hydrophobic	hydrophobic	NOUN
bjp-18180	96	23	or	or	CCONJ
bjp-18180	96	24	hydrophilic	hydrophilic	NOUN
bjp-18180	96	25	or	or	CCONJ
bjp-18180	96	26	by	by	ADP
bjp-18180	96	27	forming	form	VERB
bjp-18180	96	28	both	both	PRON
bjp-18180	96	29	.	.	PUNCT
bjp-18180	97	1	docking	dock	VERB
bjp-18180	97	2	and	and	CCONJ
bjp-18180	97	3	binding	bind	VERB
bjp-18180	97	4	energy	energy	NOUN
bjp-18180	97	5	result	result	NOUN
bjp-18180	97	6	shows	show	VERB
bjp-18180	97	7	that	that	SCONJ
bjp-18180	97	8	all	all	DET
bjp-18180	97	9	designed	design	VERB
bjp-18180	97	10	compounds	compound	NOUN
bjp-18180	97	11	fulfill	fulfill	VERB
bjp-18180	97	12	the	the	DET
bjp-18180	97	13	desired	desire	VERB
bjp-18180	97	14	criteria	criterion	NOUN
bjp-18180	97	15	,	,	PUNCT
bjp-18180	97	16	to	to	PART
bjp-18180	97	17	fit	fit	VERB
bjp-18180	97	18	properly	properly	ADV
bjp-18180	97	19	and	and	CCONJ
bjp-18180	97	20	to	to	PART
bjp-18180	97	21	interact	interact	VERB
bjp-18180	97	22	extensively	extensively	ADV
bjp-18180	97	23	with	with	ADP
bjp-18180	97	24	residues	residue	NOUN
bjp-18180	97	25	framing	frame	VERB
bjp-18180	97	26	binding	bind	VERB
bjp-18180	97	27	site	site	NOUN
bjp-18180	97	28	.	.	PUNCT
bjp-18180	98	1	the	the	DET
bjp-18180	98	2	molecular	molecular	ADJ
bjp-18180	98	3	properties	property	NOUN
bjp-18180	98	4	of	of	ADP
bjp-18180	98	5	the	the	DET
bjp-18180	98	6	analogues	analogue	NOUN
bjp-18180	98	7	were	be	AUX
bjp-18180	98	8	given	give	VERB
bjp-18180	98	9	in	in	ADP
bjp-18180	98	10	the	the	DET
bjp-18180	98	11	table	table	NOUN
bjp-18180	98	12	ii	ii	PROPN
bjp-18180	98	13	.	.	PUNCT
bjp-18180	99	1	tetrazole	tetrazole	PROPN
bjp-18180	99	2	moiety	moiety	NOUN
bjp-18180	99	3	at	at	ADP
bjp-18180	99	4	3	3	NUM
bjp-18180	99	5	and	and	CCONJ
bjp-18180	99	6	6	6	NUM
bjp-18180	99	7	were	be	AUX
bjp-18180	99	8	found	find	VERB
bjp-18180	99	9	to	to	PART
bjp-18180	99	10	be	be	AUX
bjp-18180	99	11	more	more	ADV
bjp-18180	99	12	interactive	interactive	ADJ
bjp-18180	99	13	with	with	ADP
bjp-18180	99	14	binding	bind	VERB
bjp-18180	99	15	sites	site	NOUN
bjp-18180	99	16	present	present	ADJ
bjp-18180	99	17	on	on	ADP
bjp-18180	99	18	protein	protein	NOUN
bjp-18180	99	19	in	in	ADP
bjp-18180	99	20	compound	compound	NOUN
bjp-18180	99	21	xn2	xn2	PROPN
bjp-18180	99	22	.	.	PUNCT
bjp-18180	100	1	pentyloxy	pentyloxy	PROPN
bjp-18180	100	2	substituted	substitute	VERB
bjp-18180	100	3	1,3	1,3	NUM
bjp-18180	100	4	dihydroxyxanthone(xm9	dihydroxyxanthone(xm9	NOUN
bjp-18180	100	5	)	)	PUNCT
bjp-18180	100	6	at	at	ADP
bjp-18180	100	7	position	position	NOUN
bjp-18180	100	8	c3	c3	PROPN
bjp-18180	100	9	was	be	AUX
bjp-18180	100	10	found	find	VERB
bjp-18180	100	11	to	to	ADP
bjp-18180	100	12	more	more	ADV
bjp-18180	100	13	interactive	interactive	ADJ
bjp-18180	100	14	than	than	ADP
bjp-18180	100	15	ethyloxy	ethyloxy	ADJ
bjp-18180	100	16	,	,	PUNCT
bjp-18180	100	17	propyloxy	propyloxy	ADJ
bjp-18180	100	18	,	,	PUNCT
bjp-18180	100	19	butyloxy	butyloxy	NOUN
bjp-18180	100	20	,	,	PUNCT
bjp-18180	100	21	substituted	substitute	VERB
bjp-18180	100	22	1,3	1,3	NUM
bjp-18180	100	23	dihydro210	dihydro210	PROPN
bjp-18180	100	24	bangladesh	bangladesh	PROPN
bjp-18180	100	25	j	j	PROPN
bjp-18180	100	26	pharmacol	pharmacol	PROPN
bjp-18180	100	27	2014	2014	NUM
bjp-18180	100	28	;	;	PUNCT
bjp-18180	100	29	9	9	NUM
bjp-18180	100	30	:	:	SYM
bjp-18180	100	31	208	208	NUM
bjp-18180	100	32	-	-	SYM
bjp-18180	100	33	217	217	NUM
bjp-18180	100	34	bangladesh	bangladesh	NOUN
bjp-18180	100	35	j	j	PROPN
bjp-18180	100	36	pharmacol	pharmacol	PROPN
bjp-18180	100	37	2014	2014	NUM
bjp-18180	100	38	;	;	PUNCT
bjp-18180	100	39	9	9	NUM
bjp-18180	100	40	:	:	SYM
bjp-18180	100	41	208	208	NUM
bjp-18180	100	42	-	-	SYM
bjp-18180	100	43	217	217	NUM
bjp-18180	100	44	211	211	NUM
bjp-18180	100	45	figure	figure	NOUN
bjp-18180	100	46	1	1	NUM
bjp-18180	100	47	:	:	PUNCT
bjp-18180	100	48	sequence	sequence	NOUN
bjp-18180	100	49	alignment	alignment	NOUN
bjp-18180	100	50	between	between	ADP
bjp-18180	100	51	query	query	NOUN
bjp-18180	100	52	(	(	PUNCT
bjp-18180	100	53	topoisomerase	topoisomerase	PROPN
bjp-18180	100	54	ii	ii	PROPN
bjp-18180	100	55	)	)	PUNCT
bjp-18180	100	56	of	of	ADP
bjp-18180	100	57	human	human	NOUN
bjp-18180	100	58	and	and	CCONJ
bjp-18180	100	59	subject	subject	ADJ
bjp-18180	100	60	(	(	PUNCT
bjp-18180	100	61	4gfh	4gfh	PROPN
bjp-18180	100	62	a	a	X
bjp-18180	100	63	)	)	PUNCT
bjp-18180	100	64	212	212	NUM
bjp-18180	100	65	bangladesh	bangladesh	NOUN
bjp-18180	100	66	j	j	PROPN
bjp-18180	100	67	pharmacol	pharmacol	PROPN
bjp-18180	100	68	2014	2014	NUM
bjp-18180	100	69	;	;	PUNCT
bjp-18180	100	70	9	9	NUM
bjp-18180	100	71	:	:	SYM
bjp-18180	100	72	208	208	NUM
bjp-18180	100	73	-	-	SYM
bjp-18180	100	74	217	217	NUM
bjp-18180	100	75	table	table	NOUN
bjp-18180	100	76	i	i	PRON
bjp-18180	100	77	chemical	chemical	NOUN
bjp-18180	100	78	structures	structure	NOUN
bjp-18180	100	79	of	of	ADP
bjp-18180	100	80	11	11	NUM
bjp-18180	100	81	novel	novel	ADJ
bjp-18180	100	82	hybrid	hybrid	ADJ
bjp-18180	100	83	substituted	substitute	VERB
bjp-18180	100	84	xanthones	xanthone	NOUN
bjp-18180	100	85	compound	compound	NOUN
bjp-18180	100	86	name	name	NOUN
bjp-18180	100	87	r1	r1	PROPN
bjp-18180	100	88	r2	r2	PROPN
bjp-18180	100	89	r3	r3	PROPN
bjp-18180	100	90	xm7	xm7	NOUN
bjp-18180	101	1	hn	hn	PROPN
bjp-18180	101	2	nh	nh	PROPN
bjp-18180	101	3	s	s	PROPN
bjp-18180	101	4	n	n	PROPN
bjp-18180	101	5	h3c	h3c	PROPN
bjp-18180	101	6	ch3	ch3	PROPN
bjp-18180	101	7	h	h	NOUN
bjp-18180	102	1	oh	oh	INTJ
bjp-18180	102	2	xm8	xm8	INTJ
bjp-18180	103	1	hn	hn	PROPN
bjp-18180	103	2	nh	nh	PROPN
bjp-18180	103	3	s	s	PROPN
bjp-18180	103	4	n	n	PROPN
bjp-18180	103	5	h3c	h3c	PROPN
bjp-18180	103	6	ch3	ch3	PROPN
bjp-18180	103	7	h	h	NOUN
bjp-18180	104	1	oh	oh	INTJ
bjp-18180	104	2	xm9	xm9	INTJ
bjp-18180	105	1	hn	hn	PROPN
bjp-18180	105	2	nh	nh	PROPN
bjp-18180	105	3	s	s	PROPN
bjp-18180	105	4	n	n	PROPN
bjp-18180	105	5	h3c	h3c	PROPN
bjp-18180	105	6	ch3	ch3	PROPN
bjp-18180	105	7	h	h	PROPN
bjp-18180	106	1	oh	oh	INTJ
bjp-18180	106	2	x137	x137	NUM
bjp-18180	107	1	h	h	NOUN
bjp-18180	107	2	h	h	NOUN
bjp-18180	108	1	oh	oh	INTJ
bjp-18180	108	2	xl2	xl2	INTJ
bjp-18180	108	3	n	n	CCONJ
bjp-18180	108	4	n	n	CCONJ
bjp-18180	108	5	n	n	CCONJ
bjp-18180	108	6	n	n	NOUN
bjp-18180	108	7	h	h	NOUN
bjp-18180	109	1	h	h	NOUN
bjp-18180	109	2	xlnu	xlnu	PROPN
bjp-18180	109	3	n	n	ADP
bjp-18180	110	1	o	o	NOUN
bjp-18180	111	1	hn	hn	INTJ
bjp-18180	111	2	n	n	INTJ
bjp-18180	111	3	o	o	NOUN
bjp-18180	111	4	cl	cl	NOUN
bjp-18180	112	1	h	h	NOUN
bjp-18180	112	2	h	h	NOUN
bjp-18180	112	3	xn2	xn2	PROPN
bjp-18180	113	1	n	n	CCONJ
bjp-18180	113	2	n	n	CCONJ
bjp-18180	113	3	n	n	CCONJ
bjp-18180	113	4	n	n	CCONJ
bjp-18180	113	5	r3	r3	NOUN
bjp-18180	113	6	=	=	SYM
bjp-18180	113	7	or2	or2	PROPN
bjp-18180	113	8	h	h	NOUN
bjp-18180	113	9	xnt	xnt	PROPN
bjp-18180	113	10	n	n	PROPN
bjp-18180	113	11	n	n	NOUN
bjp-18180	113	12	h	h	NOUN
bjp-18180	114	1	o	o	NOUN
bjp-18180	114	2	nh2	nh2	PROPN
bjp-18180	114	3	r3	r3	PROPN
bjp-18180	114	4	=	=	SYM
bjp-18180	114	5	or2	or2	PROPN
bjp-18180	114	6	h	h	PROPN
bjp-18180	114	7	xls	xls	PROPN
bjp-18180	114	8	c12h25	c12h25	PROPN
bjp-18180	114	9	h	h	PROPN
bjp-18180	115	1	h	h	PROPN
bjp-18180	115	2	xns	xns	PROPN
bjp-18180	115	3	c12h25	c12h25	PROPN
bjp-18180	115	4	c12h25o	c12h25o	PROPN
bjp-18180	115	5	h	h	PROPN
bjp-18180	115	6	xmun	xmun	PROPN
bjp-18180	115	7	c12h25	c12h25	PROPN
bjp-18180	115	8	h	h	PROPN
bjp-18180	116	1	oh	oh	INTJ
bjp-18180	116	2	xyxanthones	xyxanthones	PROPN
bjp-18180	116	3	.	.	PUNCT
bjp-18180	117	1	very	very	ADV
bjp-18180	117	2	lengthy	lengthy	ADJ
bjp-18180	117	3	or	or	CCONJ
bjp-18180	117	4	heavy	heavy	ADJ
bjp-18180	117	5	alkoxy	alkoxy	ADJ
bjp-18180	117	6	side	side	NOUN
bjp-18180	117	7	chain	chain	NOUN
bjp-18180	117	8	does	do	AUX
bjp-18180	117	9	not	not	PART
bjp-18180	117	10	improve	improve	VERB
bjp-18180	117	11	interaction	interaction	NOUN
bjp-18180	117	12	of	of	ADP
bjp-18180	117	13	basic	basic	ADJ
bjp-18180	117	14	nucleus	nucleus	NOUN
bjp-18180	117	15	sufficiently	sufficiently	ADV
bjp-18180	117	16	(	(	PUNCT
bjp-18180	117	17	x137	x137	NUM
bjp-18180	117	18	,	,	PUNCT
bjp-18180	117	19	xmun	xmun	PROPN
bjp-18180	117	20	)	)	PUNCT
bjp-18180	117	21	.	.	PUNCT
bjp-18180	118	1	admet	admet	PROPN
bjp-18180	118	2	studies	study	NOUN
bjp-18180	118	3	and	and	CCONJ
bjp-18180	118	4	drug	drug	NOUN
bjp-18180	118	5	likeness	likeness	NOUN
bjp-18180	118	6	of	of	ADP
bjp-18180	118	7	designed	design	VERB
bjp-18180	118	8	11	11	NUM
bjp-18180	118	9	compounds	compound	NOUN
bjp-18180	118	10	were	be	AUX
bjp-18180	118	11	done	do	VERB
bjp-18180	118	12	by	by	ADP
bjp-18180	118	13	using	use	VERB
bjp-18180	118	14	osiris	osiris	PROPN
bjp-18180	118	15	property	property	NOUN
bjp-18180	118	16	explorer	explorer	NOUN
bjp-18180	118	17	,	,	PUNCT
bjp-18180	118	18	medchem	medchem	NOUN
bjp-18180	118	19	draw	draw	ADJ
bjp-18180	118	20	freeware	freeware	NOUN
bjp-18180	118	21	.	.	PUNCT
bjp-18180	119	1	adme	adme	NOUN
bjp-18180	119	2	profile	profile	NOUN
bjp-18180	119	3	shows	show	VERB
bjp-18180	119	4	that	that	SCONJ
bjp-18180	119	5	that	that	SCONJ
bjp-18180	119	6	these	these	DET
bjp-18180	119	7	candidates	candidate	NOUN
bjp-18180	119	8	are	be	AUX
bjp-18180	119	9	hydrophobic	hydrophobic	ADJ
bjp-18180	119	10	in	in	ADP
bjp-18180	119	11	nature	nature	NOUN
bjp-18180	119	12	and	and	CCONJ
bjp-18180	119	13	thus	thus	ADV
bjp-18180	119	14	acted	act	VERB
bjp-18180	119	15	as	as	ADP
bjp-18180	119	16	hydrophilic	hydrophilic	ADJ
bjp-18180	119	17	neutral	neutral	ADJ
bjp-18180	119	18	drug	drug	NOUN
bjp-18180	119	19	molecule	molecule	NOUN
bjp-18180	119	20	by	by	ADP
bjp-18180	119	21	their	their	PRON
bjp-18180	119	22	obedience	obedience	NOUN
bjp-18180	119	23	to	to	ADP
bjp-18180	119	24	the	the	DET
bjp-18180	119	25	properties	property	NOUN
bjp-18180	119	26	such	such	ADJ
bjp-18180	119	27	as	as	ADP
bjp-18180	119	28	absorption	absorption	NOUN
bjp-18180	119	29	,	,	PUNCT
bjp-18180	119	30	distribution	distribution	NOUN
bjp-18180	119	31	,	,	PUNCT
bjp-18180	119	32	metabolism	metabolism	NOUN
bjp-18180	119	33	,	,	PUNCT
bjp-18180	119	34	and	and	CCONJ
bjp-18180	119	35	excretion	excretion	NOUN
bjp-18180	119	36	(	(	PUNCT
bjp-18180	119	37	adme	adme	NOUN
bjp-18180	119	38	)	)	PUNCT
bjp-18180	119	39	determined	determine	VERB
bjp-18180	119	40	by	by	ADP
bjp-18180	119	41	using	use	VERB
bjp-18180	119	42	medchem	medchem	NOUN
bjp-18180	119	43	designer	designer	NOUN
bjp-18180	119	44	draw	draw	VERB
bjp-18180	119	45	freeware	freeware	NOUN
bjp-18180	119	46	.	.	PUNCT
bjp-18180	120	1	toxicity	toxicity	NOUN
bjp-18180	120	2	profile	profile	NOUN
bjp-18180	120	3	which	which	PRON
bjp-18180	120	4	includes	include	VERB
bjp-18180	120	5	tumeriogenicity	tumeriogenicity	NOUN
bjp-18180	120	6	,	,	PUNCT
bjp-18180	120	7	mutagenecity	mutagenecity	NOUN
bjp-18180	120	8	,	,	PUNCT
bjp-18180	120	9	in	in	ADP
bjp-18180	120	10	combination	combination	NOUN
bjp-18180	120	11	with	with	ADP
bjp-18180	120	12	failure	failure	NOUN
bjp-18180	120	13	in	in	ADP
bjp-18180	120	14	producing	produce	VERB
bjp-18180	120	15	reproducible	reproducible	ADJ
bjp-18180	120	16	effect	effect	NOUN
bjp-18180	120	17	by	by	ADP
bjp-18180	120	18	compounds	compound	NOUN
bjp-18180	120	19	and	and	CCONJ
bjp-18180	120	20	drug	drug	NOUN
bjp-18180	120	21	scores	score	NOUN
bjp-18180	120	22	were	be	AUX
bjp-18180	120	23	studied	study	VERB
bjp-18180	120	24	using	use	VERB
bjp-18180	120	25	osiris	osiris	PROPN
bjp-18180	120	26	property	property	NOUN
bjp-18180	120	27	explorer	explorer	NOUN
bjp-18180	120	28	,	,	PUNCT
bjp-18180	120	29	all	all	DET
bjp-18180	120	30	compounds	compound	NOUN
bjp-18180	120	31	except	except	SCONJ
bjp-18180	120	32	xn2	xn2	PROPN
bjp-18180	120	33	,	,	PUNCT
bjp-18180	120	34	xn2	xn2	PROPN
bjp-18180	120	35	does	do	AUX
bjp-18180	120	36	not	not	PART
bjp-18180	120	37	passes	pass	VERB
bjp-18180	120	38	through	through	ADP
bjp-18180	120	39	these	these	DET
bjp-18180	120	40	filters	filter	NOUN
bjp-18180	120	41	.	.	PUNCT
bjp-18180	121	1	three	three	NUM
bjp-18180	121	2	compounds	compound	NOUN
bjp-18180	121	3	x137	x137	NUM
bjp-18180	121	4	,	,	PUNCT
bjp-18180	121	5	xm7	xm7	PROPN
bjp-18180	121	6	and	and	CCONJ
bjp-18180	121	7	xnt	xnt	NOUN
bjp-18180	121	8	got	get	VERB
bjp-18180	121	9	highest	high	ADJ
bjp-18180	121	10	drug	drug	NOUN
bjp-18180	121	11	likeness	likeness	NOUN
bjp-18180	121	12	score	score	NOUN
bjp-18180	121	13	of	of	ADP
bjp-18180	121	14	3.9	3.9	NUM
bjp-18180	121	15	,	,	PUNCT
bjp-18180	121	16	3.7	3.7	NUM
bjp-18180	121	17	and	and	CCONJ
bjp-18180	121	18	2.1	2.1	NUM
bjp-18180	121	19	respectively	respectively	ADV
bjp-18180	121	20	(	(	PUNCT
bjp-18180	121	21	table	table	NOUN
bjp-18180	121	22	iii	iii	NOUN
bjp-18180	121	23	)	)	PUNCT
bjp-18180	121	24	.	.	PUNCT
bjp-18180	122	1	bangladesh	bangladesh	PROPN
bjp-18180	122	2	j	j	PROPN
bjp-18180	122	3	pharmacol	pharmacol	PROPN
bjp-18180	122	4	2014	2014	NUM
bjp-18180	122	5	;	;	PUNCT
bjp-18180	122	6	9	9	NUM
bjp-18180	122	7	:	:	SYM
bjp-18180	122	8	208	208	NUM
bjp-18180	122	9	-	-	SYM
bjp-18180	122	10	217	217	NUM
bjp-18180	122	11	213	213	NUM
bjp-18180	122	12	table	table	NOUN
bjp-18180	122	13	ii	ii	NOUN
bjp-18180	122	14	molecular	molecular	ADJ
bjp-18180	122	15	descriptors	descriptor	NOUN
bjp-18180	122	16	calculated	calculate	VERB
bjp-18180	122	17	for	for	ADP
bjp-18180	122	18	different	different	ADJ
bjp-18180	122	19	novel	novel	NOUN
bjp-18180	122	20	substituted	substitute	VERB
bjp-18180	122	21	hybrid	hybrid	ADJ
bjp-18180	122	22	xanthones	xanthone	NOUN
bjp-18180	122	23	using	use	VERB
bjp-18180	122	24	medchem	medchem	NOUN
bjp-18180	122	25	designer	designer	NOUN
bjp-18180	122	26	software	software	NOUN
bjp-18180	122	27	compound	compound	NOUN
bjp-18180	122	28	name	name	NOUN
bjp-18180	122	29	slogp	slogp	NOUN
bjp-18180	123	1	s+logd	s+logd	PROPN
bjp-18180	123	2	mlogp	mlogp	ADJ
bjp-18180	123	3	hbdh	hbdh	NOUN
bjp-18180	123	4	m_no	m_no	PROPN
bjp-18180	123	5	tpsa	tpsa	NOUN
bjp-18180	123	6	rule	rule	NOUN
bjp-18180	123	7	of	of	ADP
bjp-18180	123	8	5	5	NUM
bjp-18180	123	9	hba	hba	NOUN
bjp-18180	123	10	xm7	xm7	NOUN
bjp-18180	123	11	2.8	2.8	NUM
bjp-18180	123	12	2.8	2.8	NUM
bjp-18180	123	13	1.6	1.6	NUM
bjp-18180	123	14	4.0	4.0	NUM
bjp-18180	123	15	8.00	8.00	NUM
bjp-18180	123	16	107.20	107.20	NUM
bjp-18180	123	17	0.0	0.0	NUM
bjp-18180	123	18	8	8	NUM
bjp-18180	123	19	xm8	xm8	PROPN
bjp-18180	123	20	3.1	3.1	NUM
bjp-18180	123	21	3.1	3.1	NUM
bjp-18180	123	22	1.8	1.8	NUM
bjp-18180	123	23	4.0	4.0	NUM
bjp-18180	123	24	8.00	8.00	NUM
bjp-18180	123	25	107.20	107.20	NUM
bjp-18180	123	26	0.0	0.0	NUM
bjp-18180	123	27	8	8	NUM
bjp-18180	123	28	xm9	xm9	PROPN
bjp-18180	123	29	3.5	3.5	NUM
bjp-18180	123	30	3.5	3.5	NUM
bjp-18180	123	31	2.0	2.0	NUM
bjp-18180	123	32	4.0	4.0	NUM
bjp-18180	123	33	8.00	8.00	NUM
bjp-18180	123	34	107.20	107.20	NUM
bjp-18180	123	35	0.0	0.0	NUM
bjp-18180	123	36	8	8	NUM
bjp-18180	123	37	x137	x137	NUM
bjp-18180	123	38	_	_	PUNCT
bjp-18180	124	1	_	_	PUNCT
bjp-18180	124	2	3.6	3.6	NUM
bjp-18180	124	3	2.0	2.0	NUM
bjp-18180	124	4	5.00	5.00	NUM
bjp-18180	124	5	79.9	79.9	NUM
bjp-18180	124	6	0.0	0.0	NUM
bjp-18180	124	7	5	5	NUM
bjp-18180	124	8	xl2	xl2	NOUN
bjp-18180	124	9	_	_	PUNCT
bjp-18180	125	1	_	_	PUNCT
bjp-18180	125	2	4.0	4.0	NUM
bjp-18180	125	3	1.0	1.0	NUM
bjp-18180	125	4	8.0	8.0	NUM
bjp-18180	125	5	100.0	100.0	NUM
bjp-18180	125	6	0.0	0.0	NUM
bjp-18180	125	7	8	8	NUM
bjp-18180	125	8	xlnu	xlnu	NOUN
bjp-18180	125	9	3.4	3.4	NUM
bjp-18180	125	10	3.3	3.3	NUM
bjp-18180	125	11	2.1	2.1	NUM
bjp-18180	125	12	2.0	2.0	NUM
bjp-18180	125	13	9.0	9.0	NUM
bjp-18180	125	14	121.4	121.4	NUM
bjp-18180	125	15	0.0	0.0	NUM
bjp-18180	125	16	7	7	NUM
bjp-18180	125	17	xn2	xn2	NUM
bjp-18180	125	18	_	_	PUNCT
bjp-18180	126	1	_	_	NOUN
bjp-18180	126	2	2.6	2.6	NUM
bjp-18180	126	3	3.0	3.0	NUM
bjp-18180	126	4	15.0	15.0	NUM
bjp-18180	126	5	192.4	192.4	NUM
bjp-18180	126	6	2.0	2.0	NUM
bjp-18180	126	7	11	11	NUM
bjp-18180	126	8	xnt	xnt	NOUN
bjp-18180	126	9	_	_	PUNCT
bjp-18180	127	1	_	_	PUNCT
bjp-18180	127	2	0.5	0.5	NUM
bjp-18180	127	3	7.0	7.0	NUM
bjp-18180	127	4	13.0	13.0	NUM
bjp-18180	127	5	203.9	203.9	NUM
bjp-18180	127	6	2.0	2.0	NUM
bjp-18180	127	7	13	13	NUM
bjp-18180	127	8	xls	xls	PROPN
bjp-18180	127	9	8.2	8.2	NUM
bjp-18180	127	10	8.2	8.2	NUM
bjp-18180	127	11	4.1	4.1	NUM
bjp-18180	127	12	1.0	1.0	NUM
bjp-18180	127	13	4.0	4.0	NUM
bjp-18180	127	14	59.7	59.7	NUM
bjp-18180	127	15	0.0	0.0	NUM
bjp-18180	127	16	4	4	NUM
bjp-18180	127	17	xns	xns	NOUN
bjp-18180	127	18	11.6	11.6	NUM
bjp-18180	127	19	11.6	11.6	NUM
bjp-18180	127	20	5.8	5.8	NUM
bjp-18180	127	21	1.0	1.0	NUM
bjp-18180	127	22	5.0	5.0	NUM
bjp-18180	127	23	68.9	68.9	NUM
bjp-18180	127	24	2.0	2.0	NUM
bjp-18180	127	25	5	5	NUM
bjp-18180	127	26	xmun	xmun	NUM
bjp-18180	127	27	_	_	PUNCT
bjp-18180	128	1	_	_	PUNCT
bjp-18180	128	2	3.6	3.6	NUM
bjp-18180	128	3	2.0	2.0	NUM
bjp-18180	128	4	5.0	5.0	NUM
bjp-18180	128	5	79.9	79.9	NUM
bjp-18180	128	6	0.0	0.0	NUM
bjp-18180	128	7	5	5	NUM
bjp-18180	128	8	table	table	NOUN
bjp-18180	128	9	iii	iii	X
bjp-18180	128	10	solubility	solubility	NOUN
bjp-18180	128	11	,	,	PUNCT
bjp-18180	128	12	drug	drug	NOUN
bjp-18180	128	13	likeness	likeness	NOUN
bjp-18180	128	14	and	and	CCONJ
bjp-18180	128	15	drug	drug	NOUN
bjp-18180	128	16	score	score	NOUN
bjp-18180	128	17	accounted	account	VERB
bjp-18180	128	18	by	by	ADP
bjp-18180	128	19	osiris	osiris	PROPN
bjp-18180	128	20	property	property	NOUN
bjp-18180	128	21	explorer	explorer	NOUN
bjp-18180	128	22	and	and	CCONJ
bjp-18180	128	23	with	with	ADP
bjp-18180	128	24	respect	respect	NOUN
bjp-18180	128	25	to	to	ADP
bjp-18180	128	26	binding	bind	VERB
bjp-18180	128	27	energies	energy	NOUN
bjp-18180	128	28	of	of	ADP
bjp-18180	128	29	different	different	ADJ
bjp-18180	128	30	novel	novel	NOUN
bjp-18180	128	31	substituted	substitute	VERB
bjp-18180	128	32	hybrid	hybrid	ADJ
bjp-18180	128	33	xanthones	xanthone	NOUN
bjp-18180	128	34	compound	compound	NOUN
bjp-18180	128	35	name	name	NOUN
bjp-18180	128	36	solubility	solubility	NOUN
bjp-18180	128	37	drug	drug	NOUN
bjp-18180	128	38	likeness	likeness	NOUN
bjp-18180	128	39	drug	drug	NOUN
bjp-18180	128	40	score	score	NOUN
bjp-18180	128	41	xm7	xm7	PROPN
bjp-18180	129	1	-5.4	-5.4	PROPN
bjp-18180	129	2	3.7	3.7	NUM
bjp-18180	129	3	0.4	0.4	NUM
bjp-18180	129	4	xm8	xm8	PROPN
bjp-18180	129	5	-5.7	-5.7	NUM
bjp-18180	129	6	0.3	0.3	NUM
bjp-18180	129	7	0.3	0.3	NUM
bjp-18180	129	8	xm9	xm9	INTJ
bjp-18180	129	9	-6.0	-6.0	PROPN
bjp-18180	129	10	-1.6	-1.6	PROPN
bjp-18180	129	11	0.2	0.2	NUM
bjp-18180	129	12	x137	x137	PROPN
bjp-18180	130	1	-4.0	-4.0	PUNCT
bjp-18180	130	2	-0.0	-0.0	NOUN
bjp-18180	130	3	0.4	0.4	NUM
bjp-18180	130	4	xl2	xl2	PROPN
bjp-18180	130	5	-7.2	-7.2	PROPN
bjp-18180	130	6	3.9	3.9	NUM
bjp-18180	130	7	0.2	0.2	NUM
bjp-18180	130	8	xlnu	xlnu	NOUN
bjp-18180	130	9	-6.0	-6.0	PROPN
bjp-18180	130	10	0.9	0.9	NUM
bjp-18180	130	11	0.1	0.1	NUM
bjp-18180	130	12	xn2	xn2	X
bjp-18180	131	1	-7.7	-7.7	ADJ
bjp-18180	131	2	-8.0	-8.0	PROPN
bjp-18180	131	3	0.0	0.0	NUM
bjp-18180	131	4	xnt	xnt	NOUN
bjp-18180	131	5	-7.3	-7.3	PROPN
bjp-18180	131	6	2.1	2.1	NUM
bjp-18180	131	7	0.4	0.4	NUM
bjp-18180	131	8	xls	xls	PROPN
bjp-18180	131	9	-7.7	-7.7	PROPN
bjp-18180	131	10	-20.4	-20.4	NUM
bjp-18180	131	11	0.1	0.1	NUM
bjp-18180	131	12	xns	xns	PROPN
bjp-18180	131	13	-10.7	-10.7	NOUN
bjp-18180	131	14	-22.3	-22.3	NOUN
bjp-18180	131	15	0.1	0.1	NUM
bjp-18180	131	16	xmun	xmun	PROPN
bjp-18180	131	17	-7.4	-7.4	PUNCT
bjp-18180	131	18	-20.8	-20.8	NUM
bjp-18180	131	19	0.1	0.1	NUM
bjp-18180	131	20	table	table	NOUN
bjp-18180	131	21	iv	iv	NUM
bjp-18180	131	22	solubility	solubility	NOUN
bjp-18180	131	23	,	,	PUNCT
bjp-18180	131	24	drug	drug	NOUN
bjp-18180	131	25	likeness	likeness	NOUN
bjp-18180	131	26	and	and	CCONJ
bjp-18180	131	27	drug	drug	NOUN
bjp-18180	131	28	score	score	NOUN
bjp-18180	131	29	accounted	account	VERB
bjp-18180	131	30	by	by	ADP
bjp-18180	131	31	osiris	osiris	PROPN
bjp-18180	131	32	property	property	NOUN
bjp-18180	131	33	explorer	explorer	NOUN
bjp-18180	131	34	and	and	CCONJ
bjp-18180	131	35	with	with	ADP
bjp-18180	131	36	respect	respect	NOUN
bjp-18180	131	37	to	to	ADP
bjp-18180	131	38	binding	bind	VERB
bjp-18180	131	39	energies	energy	NOUN
bjp-18180	131	40	of	of	ADP
bjp-18180	131	41	different	different	ADJ
bjp-18180	131	42	novel	novel	NOUN
bjp-18180	131	43	substituted	substitute	VERB
bjp-18180	131	44	hybrid	hybrid	ADJ
bjp-18180	131	45	xanthones	xanthone	NOUN
bjp-18180	131	46	compound	compound	NOUN
bjp-18180	131	47	name	name	NOUN
bjp-18180	131	48	residues	residue	NOUN
bjp-18180	131	49	involves	involve	VERB
bjp-18180	131	50	in	in	ADP
bjp-18180	131	51	hydrogen	hydrogen	NOUN
bjp-18180	131	52	bonding	bonding	NOUN
bjp-18180	131	53	interactions	interaction	NOUN
bjp-18180	131	54	residues	residue	NOUN
bjp-18180	131	55	involves	involve	VERB
bjp-18180	131	56	in	in	ADP
bjp-18180	131	57	hydrophobic	hydrophobic	NOUN
bjp-18180	131	58	interactions	interaction	NOUN
bjp-18180	131	59	binding	bind	VERB
bjp-18180	131	60	energy	energy	NOUN
bjp-18180	131	61	xm7	xm7	NOUN
bjp-18180	132	1	met762	met762	PROPN
bjp-18180	132	2	pro803	pro803	PROPN
bjp-18180	132	3	,	,	PUNCT
bjp-18180	132	4	ser800	ser800	PROPN
bjp-18180	132	5	,	,	PUNCT
bjp-18180	132	6	iie769	iie769	NOUN
bjp-18180	132	7	,	,	PUNCT
bjp-18180	132	8	gln773	gln773	PROPN
bjp-18180	132	9	,	,	PUNCT
bjp-18180	132	10	gly797	gly797	PROPN
bjp-18180	132	11	,	,	PUNCT
bjp-18180	132	12	gly796	gly796	PROPN
bjp-18180	132	13	,	,	PUNCT
bjp-18180	132	14	asn770	asn770	PROPN
bjp-18180	132	15	,	,	PUNCT
bjp-18180	132	16	lys798	lys798	PROPN
bjp-18180	132	17	,	,	PUNCT
bjp-18180	132	18	met766	met766	PROPN
bjp-18180	132	19	-12.7	-12.7	PROPN
bjp-18180	132	20	xm8	xm8	PROPN
bjp-18180	132	21	gln544	gln544	PROPN
bjp-18180	132	22	arg672	arg672	PROPN
bjp-18180	132	23	,	,	PUNCT
bjp-18180	132	24	pro601	pro601	PROPN
bjp-18180	132	25	,	,	PUNCT
bjp-18180	132	26	leu680	leu680	PROPN
bjp-18180	132	27	,	,	PUNCT
bjp-18180	132	28	glu682	glu682	NOUN
bjp-18180	132	29	,	,	PUNCT
bjp-18180	132	30	pro593	pro593	PROPN
bjp-18180	132	31	,	,	PUNCT
bjp-18180	132	32	tyr590	tyr590	PROPN
bjp-18180	132	33	,	,	PUNCT
bjp-18180	132	34	ser591	ser591	PROPN
bjp-18180	132	35	,	,	PUNCT
bjp-18180	132	36	glu542	glu542	PROPN
bjp-18180	132	37	,	,	PUNCT
bjp-18180	132	38	tyr686	tyr686	PROPN
bjp-18180	132	39	-11.0	-11.0	PROPN
bjp-18180	132	40	xm9	xm9	INTJ
bjp-18180	132	41	pro593	pro593	PROPN
bjp-18180	132	42	try686	try686	PROPN
bjp-18180	132	43	,	,	PUNCT
bjp-18180	132	44	gln542	gln542	PROPN
bjp-18180	132	45	,	,	PUNCT
bjp-18180	132	46	tyr590	tyr590	PROPN
bjp-18180	132	47	,	,	PUNCT
bjp-18180	132	48	iie577	iie577	PROPN
bjp-18180	132	49	,	,	PUNCT
bjp-18180	132	50	ser591	ser591	NOUN
bjp-18180	132	51	,	,	PUNCT
bjp-18180	132	52	leu705	leu705	PROPN
bjp-18180	132	53	,	,	PUNCT
bjp-18180	132	54	leu592	leu592	PROPN
bjp-18180	132	55	,	,	PUNCT
bjp-18180	132	56	tyr684	tyr684	PROPN
bjp-18180	132	57	,	,	PUNCT
bjp-18180	132	58	glu602	glu602	PROPN
bjp-18180	132	59	,	,	PUNCT
bjp-18180	132	60	asp683	asp683	PROPN
bjp-18180	132	61	,	,	PUNCT
bjp-18180	132	62	arg675	arg675	PROPN
bjp-18180	132	63	,	,	PUNCT
bjp-18180	132	64	lys701	lys701	PROPN
bjp-18180	132	65	,	,	PUNCT
bjp-18180	132	66	asp671	asp671	PROPN
bjp-18180	132	67	,	,	PUNCT
bjp-18180	132	68	iie704	iie704	NOUN
bjp-18180	132	69	,	,	PUNCT
bjp-18180	132	70	asn700	asn700	PROPN
bjp-18180	132	71	,	,	PUNCT
bjp-18180	132	72	phe668	phe668	PROPN
bjp-18180	132	73	,	,	PUNCT
bjp-18180	132	74	tyr686	tyr686	NOUN
bjp-18180	132	75	-14.3	-14.3	PRON
bjp-18180	132	76	x137	x137	NUM
bjp-18180	132	77	lys1140	lys1140	NOUN
bjp-18180	132	78	tyr1135	tyr1135	NOUN
bjp-18180	132	79	,	,	PUNCT
bjp-18180	132	80	met1131	met1131	NOUN
bjp-18180	132	81	,	,	PUNCT
bjp-18180	132	82	pro1132	pro1132	NOUN
bjp-18180	132	83	,	,	PUNCT
bjp-18180	132	84	leu128	leu128	NOUN
bjp-18180	132	85	,	,	PUNCT
bjp-18180	132	86	asp1130	asp1130	NOUN
bjp-18180	132	87	,	,	PUNCT
bjp-18180	132	88	phe1054	phe1054	NOUN
bjp-18180	132	89	,	,	PUNCT
bjp-18180	132	90	iie1055	iie1055	PROPN
bjp-18180	132	91	-6.4	-6.4	PUNCT
bjp-18180	132	92	xl2	xl2	PROPN
bjp-18180	133	1	ser756	ser756	PROPN
bjp-18180	133	2	,	,	PUNCT
bjp-18180	133	3	asp832	asp832	PROPN
bjp-18180	133	4	,	,	PUNCT
bjp-18180	133	5	tyr757	tyr757	NOUN
bjp-18180	133	6	,	,	PUNCT
bjp-18180	133	7	glu702,leu685	glu702,leu685	NUM
bjp-18180	133	8	,	,	PUNCT
bjp-18180	133	9	gln542	gln542	PROPN
bjp-18180	133	10	,	,	PUNCT
bjp-18180	133	11	tyr686	tyr686	PROPN
bjp-18180	133	12	,	,	PUNCT
bjp-18180	133	13	ser591	ser591	PROPN
bjp-18180	133	14	,	,	PUNCT
bjp-18180	133	15	pro593	pro593	PROPN
bjp-18180	133	16	,	,	PUNCT
bjp-18180	133	17	leu592	leu592	PROPN
bjp-18180	133	18	,	,	PUNCT
bjp-18180	133	19	asp543	asp543	PROPN
bjp-18180	133	20	,	,	PUNCT
bjp-18180	133	21	gly615	gly615	PROPN
bjp-18180	133	22	,	,	PUNCT
bjp-18180	133	23	lys614	lys614	PROPN
bjp-18180	133	24	,	,	PUNCT
bjp-18180	133	25	iie577	iie577	PROPN
bjp-18180	133	26	-10.5	-10.5	NOUN
bjp-18180	133	27	xlnu	xlnu	PROPN
bjp-18180	133	28	asp832	asp832	PROPN
bjp-18180	133	29	tyr757	tyr757	PROPN
bjp-18180	133	30	,	,	PUNCT
bjp-18180	133	31	lys614	lys614	PROPN
bjp-18180	133	32	,	,	PUNCT
bjp-18180	133	33	gln544	gln544	PROPN
bjp-18180	133	34	,	,	PUNCT
bjp-18180	133	35	leu705,leu685	leu705,leu685	NUM
bjp-18180	133	36	,	,	PUNCT
bjp-18180	133	37	glu702	glu702	PROPN
bjp-18180	133	38	,	,	PUNCT
bjp-18180	133	39	ser591	ser591	PROPN
bjp-18180	133	40	,	,	PUNCT
bjp-18180	133	41	tyr686	tyr686	PROPN
bjp-18180	133	42	,	,	PUNCT
bjp-18180	133	43	tyr590	tyr590	PROPN
bjp-18180	133	44	,	,	PUNCT
bjp-18180	133	45	leu592	leu592	PROPN
bjp-18180	133	46	,	,	PUNCT
bjp-18180	133	47	glu542	glu542	PROPN
bjp-18180	133	48	,	,	PUNCT
bjp-18180	133	49	iie577	iie577	PROPN
bjp-18180	133	50	,	,	PUNCT
bjp-18180	133	51	ser756	ser756	PROPN
bjp-18180	133	52	-11.9	-11.9	PROPN
bjp-18180	133	53	xn2	xn2	PROPN
bjp-18180	133	54	iie577	iie577	PROPN
bjp-18180	133	55	leu592	leu592	PROPN
bjp-18180	133	56	,	,	PUNCT
bjp-18180	133	57	his758	his758	PROPN
bjp-18180	133	58	,	,	PUNCT
bjp-18180	133	59	ser756	ser756	PROPN
bjp-18180	133	60	,	,	PUNCT
bjp-18180	133	61	asp631	asp631	PROPN
bjp-18180	133	62	,	,	PUNCT
bjp-18180	133	63	lys614	lys614	PROPN
bjp-18180	133	64	,	,	PUNCT
bjp-18180	133	65	lue705	lue705	NOUN
bjp-18180	133	66	,	,	PUNCT
bjp-18180	133	67	phe668	phe668	PROPN
bjp-18180	133	68	,	,	PUNCT
bjp-18180	133	69	asp671	asp671	PROPN
bjp-18180	133	70	,	,	PUNCT
bjp-18180	133	71	arg675	arg675	PROPN
bjp-18180	133	72	,	,	PUNCT
bjp-18180	133	73	lys701	lys701	PROPN
bjp-18180	133	74	,	,	PUNCT
bjp-18180	133	75	ser591	ser591	PROPN
bjp-18180	133	76	,	,	PUNCT
bjp-18180	133	77	asp683	asp683	PROPN
bjp-18180	133	78	,	,	PUNCT
bjp-18180	133	79	tyr686	tyr686	PROPN
bjp-18180	133	80	,	,	PUNCT
bjp-18180	133	81	gln542	gln542	NOUN
bjp-18180	133	82	-13.0	-13.0	NOUN
bjp-18180	133	83	xnt	xnt	NOUN
bjp-18180	134	1	_	_	PUNCT
bjp-18180	135	1	asn700	asn700	PROPN
bjp-18180	135	2	,	,	PUNCT
bjp-18180	135	3	asp683	asp683	PROPN
bjp-18180	135	4	,	,	PUNCT
bjp-18180	135	5	arg675	arg675	PROPN
bjp-18180	135	6	,	,	PUNCT
bjp-18180	135	7	lys701	lys701	PROPN
bjp-18180	135	8	,	,	PUNCT
bjp-18180	135	9	ser591	ser591	NOUN
bjp-18180	135	10	,	,	PUNCT
bjp-18180	135	11	leu705	leu705	PROPN
bjp-18180	135	12	,	,	PUNCT
bjp-18180	135	13	leu685	leu685	PROPN
bjp-18180	135	14	,	,	PUNCT
bjp-18180	135	15	gln542	gln542	PROPN
bjp-18180	135	16	,	,	PUNCT
bjp-18180	135	17	tyr686	tyr686	PROPN
bjp-18180	135	18	,	,	PUNCT
bjp-18180	135	19	glu702	glu702	PROPN
bjp-18180	135	20	,	,	PUNCT
bjp-18180	135	21	ser547	ser547	PROPN
bjp-18180	135	22	,	,	PUNCT
bjp-18180	135	23	pro593	pro593	PROPN
bjp-18180	135	24	,	,	PUNCT
bjp-18180	135	25	glu682	glu682	ADV
bjp-18180	135	26	,	,	PUNCT
bjp-18180	135	27	phe668	phe668	VERB
bjp-18180	135	28	-9.5	-9.5	NOUN
bjp-18180	135	29	xls	xls	PROPN
bjp-18180	135	30	leu592	leu592	PROPN
bjp-18180	135	31	ser591	ser591	PROPN
bjp-18180	135	32	,	,	PUNCT
bjp-18180	135	33	tyr686	tyr686	PROPN
bjp-18180	135	34	,	,	PUNCT
bjp-18180	135	35	asp543	asp543	PROPN
bjp-18180	135	36	,	,	PUNCT
bjp-18180	135	37	his758	his758	NOUN
bjp-18180	135	38	,	,	PUNCT
bjp-18180	135	39	gln542	gln542	PROPN
bjp-18180	135	40	,	,	PUNCT
bjp-18180	135	41	gln544	gln544	PROPN
bjp-18180	135	42	,	,	PUNCT
bjp-18180	135	43	leu685	leu685	PROPN
bjp-18180	135	44	,	,	PUNCT
bjp-18180	135	45	pro593	pro593	PROPN
bjp-18180	135	46	-7.8	-7.8	VERB
bjp-18180	135	47	xns	xns	PROPN
bjp-18180	135	48	lys520	lys520	PROPN
bjp-18180	135	49	ser527	ser527	PROPN
bjp-18180	135	50	,	,	PUNCT
bjp-18180	135	51	iie530	iie530	PROPN
bjp-18180	135	52	,	,	PUNCT
bjp-18180	135	53	asp526	asp526	PROPN
bjp-18180	135	54	,	,	PUNCT
bjp-18180	135	55	lys529	lys529	PROPN
bjp-18180	135	56	,	,	PUNCT
bjp-18180	135	57	asn433	asn433	PROPN
bjp-18180	135	58	,	,	PUNCT
bjp-18180	135	59	arg532	arg532	PROPN
bjp-18180	135	60	,	,	PUNCT
bjp-18180	135	61	gly448	gly448	PROPN
bjp-18180	135	62	,	,	PUNCT
bjp-18180	135	63	iie511	iie511	NOUN
bjp-18180	135	64	,	,	PUNCT
bjp-18180	135	65	iie435	iie435	PROPN
bjp-18180	135	66	,	,	PUNCT
bjp-18180	135	67	gly515	gly515	PROPN
bjp-18180	135	68	,	,	PUNCT
bjp-18180	135	69	tyr518	tyr518	NOUN
bjp-18180	135	70	,	,	PUNCT
bjp-18180	135	71	lys519	lys519	PROPN
bjp-18180	135	72	,	,	PUNCT
bjp-18180	135	73	gln517	gln517	PROPN
bjp-18180	135	74	,	,	PUNCT
bjp-18180	135	75	leu516	leu516	PROPN
bjp-18180	135	76	-11.3	-11.3	PROPN
bjp-18180	135	77	xmun	xmun	PROPN
bjp-18180	135	78	pro593	pro593	PROPN
bjp-18180	135	79	his758,leu592	his758,leu592	NOUN
bjp-18180	135	80	,	,	PUNCT
bjp-18180	135	81	iie577	iie577	PROPN
bjp-18180	135	82	,	,	PUNCT
bjp-18180	135	83	glu702	glu702	PROPN
bjp-18180	135	84	,	,	PUNCT
bjp-18180	135	85	tyr686	tyr686	PROPN
bjp-18180	135	86	,	,	PUNCT
bjp-18180	135	87	leu685	leu685	PROPN
bjp-18180	135	88	,	,	PUNCT
bjp-18180	135	89	tyr684	tyr684	PROPN
bjp-18180	135	90	,	,	PUNCT
bjp-18180	135	91	gln542	gln542	PROPN
bjp-18180	135	92	,	,	PUNCT
bjp-18180	135	93	ser591	ser591	NOUN
bjp-18180	135	94	,	,	PUNCT
bjp-18180	135	95	leu705	leu705	NOUN
bjp-18180	135	96	,	,	PUNCT
bjp-18180	135	97	glu682	glu682	ADV
bjp-18180	135	98	,	,	PUNCT
bjp-18180	135	99	glu544	glu544	PROPN
bjp-18180	135	100	-6.8	-6.8	PROPN
bjp-18180	135	101	all	all	PRON
bjp-18180	135	102	eleven	eleven	NUM
bjp-18180	135	103	compounds	compound	NOUN
bjp-18180	135	104	shows	show	VERB
bjp-18180	135	105	high	high	ADJ
bjp-18180	135	106	degree	degree	NOUN
bjp-18180	135	107	of	of	ADP
bjp-18180	135	108	interactions	interaction	NOUN
bjp-18180	135	109	with	with	ADP
bjp-18180	135	110	human	human	ADJ
bjp-18180	135	111	topoisomerase	topoisomerase	ADJ
bjp-18180	135	112	ii	ii	PROPN
bjp-18180	135	113	as	as	SCONJ
bjp-18180	135	114	analyzed	analyze	VERB
bjp-18180	135	115	during	during	ADP
bjp-18180	135	116	docking	dock	VERB
bjp-18180	135	117	studies	study	NOUN
bjp-18180	135	118	.	.	PUNCT
bjp-18180	136	1	compound	compound	NOUN
bjp-18180	136	2	xm7	xm7	PROPN
bjp-18180	136	3	interacts	interact	VERB
bjp-18180	136	4	with	with	ADP
bjp-18180	136	5	met762	met762	PROPN
bjp-18180	136	6	,	,	PUNCT
bjp-18180	136	7	pro803	pro803	PROPN
bjp-18180	136	8	,	,	PUNCT
bjp-18180	136	9	ser800	ser800	PROPN
bjp-18180	136	10	,	,	PUNCT
bjp-18180	136	11	iie769	iie769	NOUN
bjp-18180	136	12	,	,	PUNCT
bjp-18180	136	13	gln773	gln773	PROPN
bjp-18180	136	14	,	,	PUNCT
bjp-18180	136	15	gly797	gly797	PROPN
bjp-18180	136	16	,	,	PUNCT
bjp-18180	136	17	gly796	gly796	PROPN
bjp-18180	136	18	,	,	PUNCT
bjp-18180	136	19	asn770	asn770	PROPN
bjp-18180	136	20	,	,	PUNCT
bjp-18180	136	21	lys798	lys798	NOUN
bjp-18180	136	22	and	and	CCONJ
bjp-18180	136	23	met766	met766	NOUN
bjp-18180	136	24	residues	residue	NOUN
bjp-18180	136	25	of	of	ADP
bjp-18180	136	26	human	human	ADJ
bjp-18180	136	27	topo	topo	PROPN
bjp-18180	136	28	ii	ii	PROPN
bjp-18180	136	29	.	.	PUNCT
bjp-18180	137	1	sulfur	sulfur	NOUN
bjp-18180	137	2	present	present	ADJ
bjp-18180	137	3	in	in	ADP
bjp-18180	137	4	side	side	NOUN
bjp-18180	137	5	chain	chain	NOUN
bjp-18180	137	6	of	of	ADP
bjp-18180	137	7	xm7	xm7	PROPN
bjp-18180	137	8	interacts	interact	VERB
bjp-18180	137	9	with	with	ADP
bjp-18180	137	10	lys798	lys798	PROPN
bjp-18180	137	11	,	,	PUNCT
bjp-18180	137	12	alkyl	alkyl	NOUN
bjp-18180	137	13	residues	residue	NOUN
bjp-18180	137	14	at	at	ADP
bjp-18180	137	15	terminal	terminal	ADJ
bjp-18180	137	16	end	end	NOUN
bjp-18180	137	17	interacts	interact	VERB
bjp-18180	137	18	with	with	ADP
bjp-18180	137	19	gln773	gln773	PROPN
bjp-18180	137	20	,	,	PUNCT
bjp-18180	137	21	gly797	gly797	PROPN
bjp-18180	137	22	,	,	PUNCT
bjp-18180	137	23	gly796	gly796	PROPN
bjp-18180	137	24	,	,	PUNCT
bjp-18180	137	25	lys798	lys798	PROPN
bjp-18180	137	26	,	,	PUNCT
bjp-18180	137	27	oxygen	oxygen	NOUN
bjp-18180	137	28	of	of	ADP
bjp-18180	137	29	alkoxy	alkoxy	ADJ
bjp-18180	137	30	side	side	NOUN
bjp-18180	137	31	chain	chain	NOUN
bjp-18180	137	32	interacts	interact	VERB
bjp-18180	137	33	with	with	ADP
bjp-18180	137	34	iie769	iie769	NOUN
bjp-18180	137	35	,	,	PUNCT
bjp-18180	137	36	carbonyl	carbonyl	NOUN
bjp-18180	137	37	oxygen	oxygen	NOUN
bjp-18180	137	38	at	at	ADP
bjp-18180	137	39	c9	c9	NOUN
bjp-18180	137	40	and	and	CCONJ
bjp-18180	137	41	oxygen	oxygen	NOUN
bjp-18180	137	42	atom	atom	NOUN
bjp-18180	137	43	at	at	ADP
bjp-18180	137	44	c4	c4	PROPN
bjp-18180	137	45	shows	show	VERB
bjp-18180	137	46	hydrogen	hydrogen	NOUN
bjp-18180	137	47	bond	bond	NOUN
bjp-18180	137	48	interaction	interaction	NOUN
bjp-18180	137	49	214	214	NUM
bjp-18180	137	50	bangladesh	bangladesh	NOUN
bjp-18180	137	51	j	j	PROPN
bjp-18180	137	52	pharmacol	pharmacol	PROPN
bjp-18180	137	53	2014	2014	NUM
bjp-18180	137	54	;	;	PUNCT
bjp-18180	137	55	9	9	NUM
bjp-18180	137	56	:	:	SYM
bjp-18180	137	57	208	208	NUM
bjp-18180	137	58	-	-	SYM
bjp-18180	137	59	217	217	NUM
bjp-18180	137	60	ramachandran	ramachandran	PROPN
bjp-18180	137	61	plot	plot	NOUN
bjp-18180	137	62	input_atom_only	input_atom_only	ADV
bjp-18180	137	63	-180	-180	PROPN
bjp-18180	137	64	-135	-135	PROPN
bjp-18180	137	65	-90	-90	PUNCT
bjp-18180	137	66	-45	-45	SYM
bjp-18180	137	67	0	0	NUM
bjp-18180	137	68	45	45	NUM
bjp-18180	137	69	90	90	NUM
bjp-18180	137	70	135	135	NUM
bjp-18180	137	71	180	180	NUM
bjp-18180	137	72	phi	phi	NOUN
bjp-18180	137	73	(	(	PUNCT
bjp-18180	137	74	degrees	degree	NOUN
bjp-18180	137	75	)	)	PUNCT
bjp-18180	137	76	180	180	NUM
bjp-18180	137	77	135	135	NUM
bjp-18180	137	78	90	90	NUM
bjp-18180	137	79	45	45	NUM
bjp-18180	137	80	0	0	NUM
bjp-18180	137	81	-45	-45	PUNCT
bjp-18180	137	82	-90	-90	PUNCT
bjp-18180	138	1	-135	-135	INTJ
bjp-18180	138	2	ps	ps	INTJ
bjp-18180	138	3	i	i	PRON
bjp-18180	138	4	(	(	PUNCT
bjp-18180	138	5	de	de	X
bjp-18180	138	6	gr	gr	ADP
bjp-18180	138	7	ee	ee	PROPN
bjp-18180	138	8	s	s	PART
bjp-18180	138	9	)	)	PUNCT
bjp-18180	138	10	figure	figure	NOUN
bjp-18180	138	11	2	2	NUM
bjp-18180	138	12	:	:	PUNCT
bjp-18180	138	13	ramachandran	ramachandran	NOUN
bjp-18180	138	14	plot	plot	NOUN
bjp-18180	138	15	showed	show	VERB
bjp-18180	138	16	that	that	SCONJ
bjp-18180	138	17	most	most	ADJ
bjp-18180	138	18	of	of	ADP
bjp-18180	138	19	the	the	DET
bjp-18180	138	20	residues	residue	NOUN
bjp-18180	138	21	of	of	ADP
bjp-18180	138	22	the	the	DET
bjp-18180	138	23	modeled	model	VERB
bjp-18180	138	24	contains	contain	VERB
bjp-18180	138	25	most	most	ADJ
bjp-18180	138	26	of	of	ADP
bjp-18180	138	27	the	the	DET
bjp-18180	138	28	residues	residue	NOUN
bjp-18180	138	29	in	in	ADP
bjp-18180	138	30	favored	favored	ADJ
bjp-18180	138	31	region	region	NOUN
bjp-18180	138	32	(	(	PUNCT
bjp-18180	138	33	85.5	85.5	NUM
bjp-18180	138	34	%	%	NOUN
bjp-18180	138	35	)	)	PUNCT
bjp-18180	138	36	,	,	PUNCT
bjp-18180	138	37	additional	additional	ADJ
bjp-18180	138	38	region	region	NOUN
bjp-18180	138	39	(	(	PUNCT
bjp-18180	138	40	12.9	12.9	NUM
bjp-18180	138	41	%	%	NOUN
bjp-18180	138	42	)	)	PUNCT
bjp-18180	138	43	,	,	PUNCT
bjp-18180	138	44	generously	generously	ADV
bjp-18180	138	45	allowed	allow	VERB
bjp-18180	138	46	region	region	NOUN
bjp-18180	138	47	(	(	PUNCT
bjp-18180	138	48	1.2	1.2	NUM
bjp-18180	138	49	%	%	NOUN
bjp-18180	138	50	)	)	PUNCT
bjp-18180	138	51	and	and	CCONJ
bjp-18180	138	52	only	only	ADV
bjp-18180	138	53	3	3	NUM
bjp-18180	138	54	residues	residue	NOUN
bjp-18180	138	55	(	(	PUNCT
bjp-18180	138	56	glu	glu	NOUN
bjp-18180	138	57	1102	1102	NUM
bjp-18180	138	58	,	,	PUNCT
bjp-18180	138	59	glu	glu	NOUN
bjp-18180	138	60	1109	1109	NUM
bjp-18180	138	61	and	and	CCONJ
bjp-18180	138	62	ser	ser	NOUN
bjp-18180	138	63	1115	1115	NUM
bjp-18180	138	64	)	)	PUNCT
bjp-18180	139	1	i.e	i.e	PRON
bjp-18180	139	2	0.4	0.4	NUM
bjp-18180	139	3	%	%	NOUN
bjp-18180	139	4	in	in	ADP
bjp-18180	139	5	disallowed	disallow	VERB
bjp-18180	139	6	residues	residue	NOUN
bjp-18180	139	7	binding	bind	VERB
bjp-18180	139	8	pocket	pocket	NOUN
bjp-18180	139	9	figure	figure	NOUN
bjp-18180	139	10	3	3	NUM
bjp-18180	139	11	:	:	PUNCT
bjp-18180	139	12	the	the	DET
bjp-18180	139	13	surface	surface	NOUN
bjp-18180	139	14	view	view	NOUN
bjp-18180	139	15	of	of	ADP
bjp-18180	139	16	the	the	DET
bjp-18180	139	17	protein	protein	NOUN
bjp-18180	139	18	with	with	ADP
bjp-18180	139	19	the	the	DET
bjp-18180	139	20	ligand	ligand	NOUN
bjp-18180	139	21	(	(	PUNCT
bjp-18180	139	22	xm7	xm7	NOUN
bjp-18180	139	23	)	)	PUNCT
bjp-18180	139	24	binding	bind	VERB
bjp-18180	139	25	pocket	pocket	NOUN
bjp-18180	139	26	with	with	ADP
bjp-18180	139	27	met762	met762	PROPN
bjp-18180	139	28	and	and	CCONJ
bjp-18180	139	29	hydrophobic	hydrophobic	NOUN
bjp-18180	139	30	interaction	interaction	NOUN
bjp-18180	139	31	with	with	ADP
bjp-18180	139	32	met766	met766	NOUN
bjp-18180	139	33	respectively	respectively	ADV
bjp-18180	139	34	.	.	PUNCT
bjp-18180	140	1	alkoxy	alkoxy	ADJ
bjp-18180	140	2	side	side	NOUN
bjp-18180	140	3	chain	chain	NOUN
bjp-18180	140	4	of	of	ADP
bjp-18180	140	5	xm7	xm7	PROPN
bjp-18180	140	6	shows	show	VERB
bjp-18180	140	7	important	important	ADJ
bjp-18180	140	8	interactions	interaction	NOUN
bjp-18180	140	9	with	with	ADP
bjp-18180	140	10	ser800	ser800	PROPN
bjp-18180	140	11	,	,	PUNCT
bjp-18180	140	12	iie769	iie769	NOUN
bjp-18180	140	13	,	,	PUNCT
bjp-18180	140	14	asn770	asn770	NOUN
bjp-18180	140	15	and	and	CCONJ
bjp-18180	140	16	met760	met760	PROPN
bjp-18180	140	17	.	.	PUNCT
bjp-18180	141	1	targeted	target	VERB
bjp-18180	141	2	protein	protein	NOUN
bjp-18180	141	3	topo	topo	PROPN
bjp-18180	141	4	ii	ii	PROPN
bjp-18180	141	5	,	,	PUNCT
bjp-18180	141	6	has	have	VERB
bjp-18180	141	7	most	most	ADJ
bjp-18180	141	8	potential	potential	ADJ
bjp-18180	141	9	active	active	ADJ
bjp-18180	141	10	site	site	NOUN
bjp-18180	141	11	where	where	SCONJ
bjp-18180	141	12	the	the	DET
bjp-18180	141	13	ligand	ligand	NOUN
bjp-18180	141	14	could	could	AUX
bjp-18180	141	15	bind	bind	VERB
bjp-18180	141	16	and	and	CCONJ
bjp-18180	141	17	interact	interact	NOUN
bjp-18180	141	18	was	be	AUX
bjp-18180	141	19	already	already	ADV
bjp-18180	141	20	previously	previously	ADV
bjp-18180	141	21	identified	identify	VERB
bjp-18180	141	22	and	and	CCONJ
bjp-18180	141	23	reported	report	VERB
bjp-18180	141	24	.	.	PUNCT
bjp-18180	142	1	the	the	DET
bjp-18180	142	2	residues	residue	NOUN
bjp-18180	142	3	which	which	PRON
bjp-18180	142	4	were	be	AUX
bjp-18180	142	5	found	find	VERB
bjp-18180	142	6	to	to	PART
bjp-18180	142	7	be	be	AUX
bjp-18180	142	8	taking	take	VERB
bjp-18180	142	9	part	part	NOUN
bjp-18180	142	10	actively	actively	ADV
bjp-18180	142	11	in	in	ADP
bjp-18180	142	12	dimensioning	dimension	VERB
bjp-18180	142	13	the	the	DET
bjp-18180	142	14	active	active	ADJ
bjp-18180	142	15	binding	bind	VERB
bjp-18180	142	16	pocket	pocket	NOUN
bjp-18180	142	17	of	of	ADP
bjp-18180	142	18	topo	topo	PROPN
bjp-18180	142	19	ii	ii	PROPN
bjp-18180	142	20	,	,	PUNCT
bjp-18180	142	21	are	be	AUX
bjp-18180	142	22	reported	report	VERB
bjp-18180	142	23	as	as	SCONJ
bjp-18180	142	24	follows	follow	VERB
bjp-18180	142	25	:	:	PUNCT
bjp-18180	142	26	pro	pro	ADJ
bjp-18180	142	27	716	716	NUM
bjp-18180	142	28	,	,	PUNCT
bjp-18180	142	29	asp	asp	NOUN
bjp-18180	142	30	720	720	NUM
bjp-18180	142	31	,	,	PUNCT
bjp-18180	142	32	gly	gly	NOUN
bjp-18180	142	33	721	721	NUM
bjp-18180	142	34	,	,	PUNCT
bjp-18180	142	35	leu	leu	PROPN
bjp-18180	142	36	722	722	NUM
bjp-18180	142	37	,	,	PUNCT
bjp-18180	142	38	lys	lys	NOUN
bjp-18180	142	39	723	723	NUM
bjp-18180	142	40	,	,	PUNCT
bjp-18180	142	41	gln	gln	NOUN
bjp-18180	142	42	726	726	NUM
bjp-18180	142	43	,	,	PUNCT
bjp-18180	142	44	asn	asn	PROPN
bjp-18180	142	45	770	770	NUM
bjp-18180	142	46	,	,	PUNCT
bjp-18180	142	47	leu	leu	PROPN
bjp-18180	142	48	771	771	NUM
bjp-18180	142	49	,	,	PUNCT
bjp-18180	142	50	gln	gln	PROPN
bjp-18180	142	51	773	773	NUM
bjp-18180	142	52	,	,	PUNCT
bjp-18180	142	53	phe	phe	NOUN
bjp-18180	142	54	775	775	NUM
bjp-18180	142	55	,	,	PUNCT
bjp-18180	142	56	gly	gly	ADV
bjp-18180	142	57	777	777	NUM
bjp-18180	142	58	,	,	PUNCT
bjp-18180	142	59	ser778	ser778	PROPN
bjp-18180	142	60	,	,	PUNCT
bjp-18180	142	61	asn	asn	PROPN
bjp-18180	142	62	779	779	NUM
bjp-18180	142	63	,	,	PUNCT
bjp-18180	142	64	leu	leu	PROPN
bjp-18180	142	65	781	781	NUM
bjp-18180	142	66	,	,	PUNCT
bjp-18180	142	67	leu	leu	PROPN
bjp-18180	142	68	783	783	NUM
bjp-18180	142	69	,	,	PUNCT
bjp-18180	142	70	gly	gly	NOUN
bjp-18180	142	71	796	796	NUM
bjp-18180	142	72	,	,	PUNCT
bjp-18180	142	73	lys	lys	NOUN
bjp-18180	142	74	798	798	NUM
bjp-18180	142	75	,	,	PUNCT
bjp-18180	142	76	met	meet	VERB
bjp-18180	142	77	847	847	NUM
bjp-18180	142	78	,	,	PUNCT
bjp-18180	142	79	val	val	NOUN
bjp-18180	142	80	848	848	NUM
bjp-18180	142	81	,	,	PUNCT
bjp-18180	142	82	leu	leu	PROPN
bjp-18180	142	83	849	849	NUM
bjp-18180	142	84	,	,	PUNCT
bjp-18180	142	85	ile	ile	PROPN
bjp-18180	142	86	850	850	NUM
bjp-18180	142	87	,	,	PUNCT
bjp-18180	142	88	asn	asn	PROPN
bjp-18180	142	89	851	851	NUM
bjp-18180	142	90	,	,	PUNCT
bjp-18180	142	91	gly	gly	NOUN
bjp-18180	142	92	852	852	NUM
bjp-18180	142	93	,	,	PUNCT
bjp-18180	142	94	ala	ala	PROPN
bjp-18180	142	95	853	853	NUM
bjp-18180	142	96	,	,	PUNCT
bjp-18180	142	97	glu	glu	NOUN
bjp-18180	142	98	854	854	NUM
bjp-18180	142	99	,	,	PUNCT
bjp-18180	142	100	lys	lys	PROPN
bjp-18180	142	101	863	863	NUM
bjp-18180	142	102	,	,	PUNCT
bjp-18180	142	103	ile	ile	PROPN
bjp-18180	142	104	864	864	NUM
bjp-18180	142	105	,	,	PUNCT
bjp-18180	142	106	pro	pro	X
bjp-18180	142	107	865	865	NUM
bjp-18180	142	108	,	,	PUNCT
bjp-18180	142	109	asn	asn	PROPN
bjp-18180	142	110	866	866	PROPN
bjp-18180	142	111	,	,	PUNCT
bjp-18180	142	112	tyr	tyr	PROPN
bjp-18180	142	113	892	892	NUM
bjp-18180	142	114	and	and	CCONJ
bjp-18180	142	115	arg	arg	VERB
bjp-18180	142	116	929	929	NUM
bjp-18180	142	117	.	.	PUNCT
bjp-18180	143	1	compound	compound	NOUN
bjp-18180	143	2	xm7	xm7	NOUN
bjp-18180	143	3	binds	bind	VERB
bjp-18180	143	4	correctly	correctly	ADV
bjp-18180	143	5	in	in	ADP
bjp-18180	143	6	this	this	DET
bjp-18180	143	7	pocket	pocket	NOUN
bjp-18180	143	8	and	and	CCONJ
bjp-18180	143	9	was	be	AUX
bjp-18180	143	10	revealed	reveal	VERB
bjp-18180	143	11	by	by	ADP
bjp-18180	143	12	docking	dock	VERB
bjp-18180	143	13	results	result	NOUN
bjp-18180	143	14	.	.	PUNCT
bjp-18180	144	1	other	other	ADJ
bjp-18180	144	2	compounds	compound	NOUN
bjp-18180	144	3	also	also	ADV
bjp-18180	144	4	shows	show	VERB
bjp-18180	144	5	interactive	interactive	ADJ
bjp-18180	144	6	binding	bind	VERB
bjp-18180	144	7	energies	energy	NOUN
bjp-18180	144	8	against	against	ADP
bjp-18180	144	9	topo	topo	PROPN
bjp-18180	144	10	ii	ii	PROPN
bjp-18180	144	11	during	during	ADP
bjp-18180	144	12	molecular	molecular	ADJ
bjp-18180	144	13	docking	docking	NOUN
bjp-18180	144	14	studies	study	NOUN
bjp-18180	144	15	,	,	PUNCT
bjp-18180	144	16	not	not	PART
bjp-18180	144	17	in	in	ADP
bjp-18180	144	18	same	same	ADJ
bjp-18180	144	19	pocket	pocket	NOUN
bjp-18180	144	20	because	because	SCONJ
bjp-18180	144	21	topo	topo	PROPN
bjp-18180	144	22	ii	ii	PROPN
bjp-18180	144	23	proteins	protein	NOUN
bjp-18180	144	24	composed	compose	VERB
bjp-18180	144	25	of	of	ADP
bjp-18180	144	26	5	5	NUM
bjp-18180	144	27	active	active	ADJ
bjp-18180	144	28	binding	bind	VERB
bjp-18180	144	29	pockets	pocket	NOUN
bjp-18180	144	30	where	where	SCONJ
bjp-18180	144	31	ligand	ligand	NOUN
bjp-18180	144	32	/	/	SYM
bjp-18180	144	33	drug	drug	NOUN
bjp-18180	144	34	could	could	AUX
bjp-18180	144	35	bind	bind	VERB
bjp-18180	144	36	,	,	PUNCT
bjp-18180	144	37	analyzed	analyze	VERB
bjp-18180	144	38	by	by	ADP
bjp-18180	144	39	q	q	PROPN
bjp-18180	144	40	site	site	NOUN
bjp-18180	144	41	finder	finder	PROPN
bjp-18180	144	42	software	software	NOUN
bjp-18180	144	43	which	which	PRON
bjp-18180	144	44	is	be	AUX
bjp-18180	144	45	an	an	DET
bjp-18180	144	46	online	online	ADJ
bjp-18180	144	47	freeware	freeware	NOUN
bjp-18180	144	48	.	.	PUNCT
bjp-18180	145	1	the	the	DET
bjp-18180	145	2	binding	bind	VERB
bjp-18180	145	3	pocket	pocket	NOUN
bjp-18180	145	4	and	and	CCONJ
bjp-18180	145	5	the	the	DET
bjp-18180	145	6	surface	surface	NOUN
bjp-18180	145	7	analysis	analysis	NOUN
bjp-18180	145	8	of	of	ADP
bjp-18180	145	9	the	the	DET
bjp-18180	145	10	compound	compound	NOUN
bjp-18180	145	11	xm7	xm7	PROPN
bjp-18180	145	12	was	be	AUX
bjp-18180	145	13	given	give	VERB
bjp-18180	145	14	in	in	ADP
bjp-18180	145	15	the	the	DET
bjp-18180	145	16	(	(	PUNCT
bjp-18180	145	17	figure	figure	NOUN
bjp-18180	145	18	3	3	NUM
bjp-18180	145	19	)	)	PUNCT
bjp-18180	145	20	and	and	CCONJ
bjp-18180	145	21	the	the	DET
bjp-18180	145	22	hydrophobic	hydrophobic	NOUN
bjp-18180	145	23	and	and	CCONJ
bjp-18180	145	24	hydrogen	hydrogen	NOUN
bjp-18180	145	25	bond	bond	NOUN
bjp-18180	145	26	interaction	interaction	NOUN
bjp-18180	145	27	was	be	AUX
bjp-18180	145	28	analyzed	analyze	VERB
bjp-18180	145	29	(	(	PUNCT
bjp-18180	145	30	figure	figure	NOUN
bjp-18180	145	31	4	4	NUM
bjp-18180	145	32	)	)	PUNCT
bjp-18180	145	33	.	.	PUNCT
bjp-18180	146	1	binding	bind	VERB
bjp-18180	146	2	energy	energy	NOUN
bjp-18180	146	3	is	be	AUX
bjp-18180	146	4	a	a	DET
bjp-18180	146	5	versatile	versatile	ADJ
bjp-18180	146	6	tool	tool	NOUN
bjp-18180	146	7	understands	understand	VERB
bjp-18180	146	8	the	the	DET
bjp-18180	146	9	affinity	affinity	NOUN
bjp-18180	146	10	of	of	ADP
bjp-18180	146	11	the	the	DET
bjp-18180	146	12	ligand	ligand	NOUN
bjp-18180	146	13	to	to	ADP
bjp-18180	146	14	its	its	PRON
bjp-18180	146	15	binding	bind	VERB
bjp-18180	146	16	site	site	NOUN
bjp-18180	146	17	present	present	ADJ
bjp-18180	146	18	on	on	ADP
bjp-18180	146	19	protein	protein	NOUN
bjp-18180	146	20	.	.	PUNCT
bjp-18180	147	1	five	five	NUM
bjp-18180	147	2	compounds	compound	NOUN
bjp-18180	147	3	xm9	xm9	PROPN
bjp-18180	147	4	,	,	PUNCT
bjp-18180	147	5	xn2	xn2	PROPN
bjp-18180	147	6	,	,	PUNCT
bjp-18180	147	7	xm7	xm7	PROPN
bjp-18180	147	8	,	,	PUNCT
bjp-18180	147	9	xlnu	xlnu	PROPN
bjp-18180	147	10	,	,	PUNCT
bjp-18180	147	11	xns	xns	PROPN
bjp-18180	147	12	showed	show	VERB
bjp-18180	147	13	best	well	ADV
bjp-18180	147	14	and	and	CCONJ
bjp-18180	147	15	lowest	low	ADJ
bjp-18180	147	16	binding	bind	VERB
bjp-18180	147	17	energy	energy	NOUN
bjp-18180	147	18	scores	score	NOUN
bjp-18180	147	19	among	among	ADP
bjp-18180	147	20	all	all	PRON
bjp-18180	147	21	of	of	ADP
bjp-18180	147	22	the	the	DET
bjp-18180	147	23	ligands	ligand	NOUN
bjp-18180	147	24	having	have	VERB
bjp-18180	147	25	-14.3	-14.3	INTJ
bjp-18180	147	26	,	,	PUNCT
bjp-18180	147	27	-13.0	-13.0	NOUN
bjp-18180	147	28	,	,	PUNCT
bjp-18180	147	29	-12.7	-12.7	X
bjp-18180	147	30	,	,	PUNCT
bjp-18180	147	31	-11.9	-11.9	NOUN
bjp-18180	147	32	,	,	PUNCT
bjp-18180	147	33	-11.3	-11.3	NOUN
bjp-18180	147	34	kcal	kcal	NOUN
bjp-18180	147	35	/	/	SYM
bjp-18180	147	36	molrespectively	molrespectively	ADV
bjp-18180	147	37	.	.	PUNCT
bjp-18180	148	1	all	all	DET
bjp-18180	148	2	five	five	NUM
bjp-18180	148	3	compounds	compound	NOUN
bjp-18180	148	4	were	be	AUX
bjp-18180	148	5	found	find	VERB
bjp-18180	148	6	to	to	PART
bjp-18180	148	7	be	be	AUX
bjp-18180	148	8	more	more	ADV
bjp-18180	148	9	potent	potent	ADJ
bjp-18180	148	10	than	than	ADP
bjp-18180	148	11	naturally	naturally	ADV
bjp-18180	148	12	ocurring	ocurring	PROPN
bjp-18180	148	13	marine	marine	PROPN
bjp-18180	148	14	based	base	VERB
bjp-18180	148	15	triterpeneglycosides	triterpeneglycoside	NOUN
bjp-18180	148	16	,	,	PUNCT
bjp-18180	148	17	cucumarioside	cucumarioside	VERB
bjp-18180	148	18	a	a	PRON
bjp-18180	148	19	with	with	ADP
bjp-18180	148	20	docking	docking	NOUN
bjp-18180	148	21	score	score	NOUN
bjp-18180	148	22	-11.1	-11.1	PROPN
bjp-18180	148	23	kcal	kcal	NOUN
bjp-18180	148	24	/	/	SYM
bjp-18180	148	25	mol	mol	NOUN
bjp-18180	148	26	followed	follow	VERB
bjp-18180	148	27	by	by	ADP
bjp-18180	148	28	holothurinoside	holothurinoside	NOUN
bjp-18180	148	29	a	a	PRON
bjp-18180	148	30	and	and	CCONJ
bjp-18180	148	31	holothurin	holothurin	VERB
bjp-18180	148	32	a	a	PRON
bjp-18180	148	33	with	with	ADP
bjp-18180	148	34	-10.5	-10.5	X
bjp-18180	148	35	kcal	kcal	NOUN
bjp-18180	148	36	/	/	SYM
bjp-18180	148	37	mol	mol	PROPN
bjp-18180	148	38	,	,	PUNCT
bjp-18180	148	39	bivittoside	bivittoside	VERB
bjp-18180	148	40	a	a	PRON
bjp-18180	148	41	with	with	ADP
bjp-18180	148	42	-10	-10	X
bjp-18180	148	43	kcal	kcal	NOUN
bjp-18180	148	44	/	/	SYM
bjp-18180	148	45	mol	mol	PROPN
bjp-18180	148	46	,	,	PUNCT
bjp-18180	148	47	holotoxin	holotoxin	VERB
bjp-18180	148	48	a	a	PRON
bjp-18180	148	49	with	with	ADP
bjp-18180	148	50	-9.7	-9.7	ADJ
bjp-18180	148	51	kcal	kcal	NOUN
bjp-18180	148	52	/	/	SYM
bjp-18180	148	53	mol	mol	PROPN
bjp-18180	148	54	as	as	ADV
bjp-18180	148	55	well	well	ADV
bjp-18180	148	56	as	as	ADP
bjp-18180	148	57	than	than	ADP
bjp-18180	148	58	etoposide	etoposide	NOUN
bjp-18180	148	59	with	with	ADP
bjp-18180	148	60	binding	bind	VERB
bjp-18180	148	61	energy	energy	NOUN
bjp-18180	148	62	of	of	ADP
bjp-18180	148	63	-9.5	-9.5	NOUN
bjp-18180	148	64	kcal	kcal	PROPN
bjp-18180	148	65	/	/	SYM
bjp-18180	148	66	mol	mol	PROPN
bjp-18180	148	67	.	.	PUNCT
bjp-18180	148	68	compound	compound	PROPN
bjp-18180	148	69	x137	x137	PROPN
bjp-18180	148	70	got	get	AUX
bjp-18180	148	71	least	least	ADV
bjp-18180	148	72	binding	bind	VERB
bjp-18180	148	73	energy	energy	NOUN
bjp-18180	148	74	-6.4	-6.4	PROPN
bjp-18180	148	75	kcal	kcal	PROPN
bjp-18180	148	76	/	/	SYM
bjp-18180	148	77	mol	mol	PROPN
bjp-18180	148	78	.	.	PUNCT
bjp-18180	149	1	binding	bind	VERB
bjp-18180	149	2	energies	energy	NOUN
bjp-18180	149	3	of	of	ADP
bjp-18180	149	4	all	all	DET
bjp-18180	149	5	compound	compound	NOUN
bjp-18180	149	6	are	be	AUX
bjp-18180	149	7	presented	present	VERB
bjp-18180	149	8	in	in	ADP
bjp-18180	149	9	table	table	NOUN
bjp-18180	149	10	iv	iv	NOUN
bjp-18180	149	11	.	.	PUNCT
bjp-18180	150	1	the	the	DET
bjp-18180	150	2	polar	polar	ADJ
bjp-18180	150	3	interacting	interact	VERB
bjp-18180	150	4	residues	residue	NOUN
bjp-18180	150	5	forming	form	VERB
bjp-18180	150	6	hydrogen	hydrogen	NOUN
bjp-18180	150	7	bonds	bond	NOUN
bjp-18180	150	8	were	be	AUX
bjp-18180	150	9	analyzed	analyze	VERB
bjp-18180	150	10	(	(	PUNCT
bjp-18180	150	11	figure	figure	NOUN
bjp-18180	150	12	5	5	NUM
bjp-18180	150	13	)	)	PUNCT
bjp-18180	150	14	.	.	PUNCT
bjp-18180	151	1	discussion	discussion	NOUN
bjp-18180	151	2	topoisomerase	topoisomerase	PROPN
bjp-18180	151	3	ii	ii	PROPN
bjp-18180	151	4	poisons	poison	NOUN
bjp-18180	151	5	,	,	PUNCT
bjp-18180	151	6	are	be	AUX
bjp-18180	151	7	efficient	efficient	ADJ
bjp-18180	151	8	but	but	CCONJ
bjp-18180	151	9	produce	produce	VERB
bjp-18180	151	10	harmful	harmful	ADJ
bjp-18180	151	11	secondary	secondary	ADJ
bjp-18180	151	12	effects	effect	NOUN
bjp-18180	151	13	,	,	PUNCT
bjp-18180	151	14	common	common	ADJ
bjp-18180	151	15	with	with	ADP
bjp-18180	151	16	every	every	DET
bjp-18180	151	17	drug	drug	NOUN
bjp-18180	151	18	follows	follow	VERB
bjp-18180	151	19	this	this	DET
bjp-18180	151	20	path	path	NOUN
bjp-18180	151	21	,	,	PUNCT
bjp-18180	151	22	were	be	AUX
bjp-18180	151	23	myelosuppression	myelosuppression	NOUN
bjp-18180	151	24	,	,	PUNCT
bjp-18180	151	25	leucopoenia	leucopoenia	PROPN
bjp-18180	151	26	,	,	PUNCT
bjp-18180	151	27	gastrointestinal	gastrointestinal	ADJ
bjp-18180	151	28	toxicities	toxicity	NOUN
bjp-18180	151	29	,	,	PUNCT
bjp-18180	151	30	alopecia	alopecia	NOUN
bjp-18180	151	31	,	,	PUNCT
bjp-18180	151	32	and	and	CCONJ
bjp-18180	151	33	even	even	ADV
bjp-18180	151	34	leukemia	leukemia	NOUN
bjp-18180	151	35	(	(	PUNCT
bjp-18180	151	36	bailly	bailly	ADV
bjp-18180	151	37	,	,	PUNCT
bjp-18180	151	38	2012	2012	NUM
bjp-18180	151	39	)	)	PUNCT
bjp-18180	151	40	.	.	PUNCT
bjp-18180	152	1	but	but	CCONJ
bjp-18180	152	2	taking	take	VERB
bjp-18180	152	3	safety	safety	NOUN
bjp-18180	152	4	as	as	ADP
bjp-18180	152	5	a	a	DET
bjp-18180	152	6	principle	principle	ADJ
bjp-18180	152	7	criteria	criterion	NOUN
bjp-18180	152	8	,	,	PUNCT
bjp-18180	152	9	topo	topo	PROPN
bjp-18180	152	10	ii	ii	PROPN
bjp-18180	152	11	catalytic	catalytic	ADJ
bjp-18180	152	12	inhibitors	inhibitor	NOUN
bjp-18180	152	13	are	be	AUX
bjp-18180	152	14	preferential	preferential	ADJ
bjp-18180	152	15	ones	one	NOUN
bjp-18180	152	16	over	over	ADP
bjp-18180	152	17	topo	topo	PROPN
bjp-18180	152	18	ii	ii	PROPN
bjp-18180	152	19	poisons	poison	NOUN
bjp-18180	152	20	for	for	ADP
bjp-18180	152	21	designing	design	VERB
bjp-18180	152	22	.	.	PUNCT
bjp-18180	153	1	in	in	ADP
bjp-18180	153	2	cancer	cancer	NOUN
bjp-18180	153	3	cells	cell	NOUN
bjp-18180	153	4	,	,	PUNCT
bjp-18180	153	5	topo	topo	PROPN
bjp-18180	153	6	ii	ii	PROPN
bjp-18180	153	7	concentrations	concentration	NOUN
bjp-18180	153	8	are	be	AUX
bjp-18180	153	9	dramatically	dramatically	ADV
bjp-18180	153	10	upregulated	upregulate	VERB
bjp-18180	153	11	because	because	SCONJ
bjp-18180	153	12	of	of	ADP
bjp-18180	153	13	rapid	rapid	ADJ
bjp-18180	153	14	cell	cell	NOUN
bjp-18180	153	15	division	division	NOUN
bjp-18180	153	16	and	and	CCONJ
bjp-18180	153	17	cell	cell	NOUN
bjp-18180	153	18	growth	growth	NOUN
bjp-18180	153	19	(	(	PUNCT
bjp-18180	153	20	heck	heck	NOUN
bjp-18180	153	21	and	and	CCONJ
bjp-18180	153	22	earnshaw	earnshaw	PROPN
bjp-18180	153	23	,	,	PUNCT
bjp-18180	153	24	1986	1986	NUM
bjp-18180	153	25	;	;	PUNCT
bjp-18180	153	26	woessner	woessner	PROPN
bjp-18180	153	27	et	et	PROPN
bjp-18180	153	28	al	al	PROPN
bjp-18180	153	29	.	.	PROPN
bjp-18180	153	30	,	,	PUNCT
bjp-18180	153	31	1991	1991	NUM
bjp-18180	153	32	)	)	PUNCT
bjp-18180	153	33	.	.	PUNCT
bjp-18180	154	1	therefore	therefore	ADV
bjp-18180	154	2	,	,	PUNCT
bjp-18180	154	3	numbers	number	NOUN
bjp-18180	154	4	of	of	ADP
bjp-18180	154	5	anti	anti	ADJ
bjp-18180	154	6	-	-	ADJ
bjp-18180	154	7	cancer	cancer	ADJ
bjp-18180	154	8	agents	agent	NOUN
bjp-18180	154	9	are	be	AUX
bjp-18180	154	10	designed	design	VERB
bjp-18180	154	11	with	with	ADP
bjp-18180	154	12	topo	topo	PROPN
bjp-18180	154	13	ii	ii	PROPN
bjp-18180	154	14	as	as	ADP
bjp-18180	154	15	a	a	DET
bjp-18180	154	16	potential	potential	ADJ
bjp-18180	154	17	target	target	NOUN
bjp-18180	154	18	(	(	PUNCT
bjp-18180	154	19	wilstermann	wilstermann	PROPN
bjp-18180	154	20	et	et	PROPN
bjp-18180	154	21	al	al	PROPN
bjp-18180	154	22	.	.	PROPN
bjp-18180	154	23	,	,	PUNCT
bjp-18180	154	24	2003	2003	NUM
bjp-18180	154	25	;	;	PUNCT
bjp-18180	154	26	fortune	fortune	NOUN
bjp-18180	154	27	and	and	CCONJ
bjp-18180	154	28	prog	prog	NOUN
bjp-18180	154	29	,	,	PUNCT
bjp-18180	154	30	2000	2000	NUM
bjp-18180	154	31	)	)	PUNCT
bjp-18180	154	32	.	.	PUNCT
bjp-18180	155	1	trihydroxyl	trihydroxyl	PROPN
bjp-18180	155	2	xanthone	xanthone	PROPN
bjp-18180	155	3	and	and	CCONJ
bjp-18180	155	4	tetrahydroxyl	tetrahydroxyl	PROPN
bjp-18180	155	5	xanthone	xanthone	PROPN
bjp-18180	155	6	exhibited	exhibit	VERB
bjp-18180	155	7	the	the	DET
bjp-18180	155	8	highest	high	ADJ
bjp-18180	155	9	cytotoxic	cytotoxic	ADJ
bjp-18180	155	10	activities	activity	NOUN
bjp-18180	155	11	over	over	ADP
bjp-18180	155	12	other	other	ADJ
bjp-18180	155	13	compounds	compound	NOUN
bjp-18180	155	14	.	.	PUNCT
bjp-18180	156	1	a	a	DET
bjp-18180	156	2	piperidine	piperidine	NOUN
bjp-18180	156	3	side	side	NOUN
bjp-18180	156	4	chain	chain	NOUN
bjp-18180	156	5	at	at	ADP
bjp-18180	156	6	the	the	DET
bjp-18180	156	7	c-3	c-3	NOUN
bjp-18180	156	8	position	position	NOUN
bjp-18180	156	9	is	be	AUX
bjp-18180	156	10	favorable	favorable	ADJ
bjp-18180	156	11	with	with	ADP
bjp-18180	156	12	regard	regard	NOUN
bjp-18180	156	13	to	to	ADP
bjp-18180	156	14	improved	improved	ADJ
bjp-18180	156	15	cytotoxicity	cytotoxicity	NOUN
bjp-18180	156	16	.	.	PUNCT
bjp-18180	157	1	quinoline	quinoline	NOUN
bjp-18180	157	2	-	-	PUNCT
bjp-18180	157	3	containing	contain	VERB
bjp-18180	157	4	thiosemicarbazide	thiosemicarbazide	NOUN
bjp-18180	157	5	compound	compound	NOUN
bjp-18180	157	6	(	(	PUNCT
bjp-18180	157	7	tsc24	tsc24	PROPN
bjp-18180	157	8	)	)	PUNCT
bjp-18180	157	9	,	,	PUNCT
bjp-18180	157	10	have	have	AUX
bjp-18180	157	11	potent	potent	VERB
bjp-18180	157	12	anti	anti	ADJ
bjp-18180	157	13	-	-	ADJ
bjp-18180	157	14	proliferative	proliferative	ADJ
bjp-18180	157	15	activity	activity	NOUN
bjp-18180	157	16	toward	toward	ADP
bjp-18180	157	17	cancer	cancer	NOUN
bjp-18180	157	18	cells	cell	NOUN
bjp-18180	157	19	.	.	PUNCT
bjp-18180	158	1	nitrogen	nitrogen	NOUN
bjp-18180	158	2	containing	contain	VERB
bjp-18180	158	3	groups	group	NOUN
bjp-18180	158	4	like	like	ADP
bjp-18180	158	5	nitro	nitro	NOUN
bjp-18180	158	6	,	,	PUNCT
bjp-18180	158	7	amide	amide	NOUN
bjp-18180	158	8	and	and	CCONJ
bjp-18180	158	9	amines	amine	NOUN
bjp-18180	158	10	in	in	ADP
bjp-18180	158	11	chemical	chemical	NOUN
bjp-18180	158	12	structure	structure	NOUN
bjp-18180	158	13	are	be	AUX
bjp-18180	158	14	general	general	ADJ
bjp-18180	158	15	requirement	requirement	NOUN
bjp-18180	158	16	for	for	ADP
bjp-18180	158	17	designing	design	VERB
bjp-18180	158	18	topo	topo	PROPN
bjp-18180	158	19	ii	ii	PROPN
bjp-18180	158	20	inhibitors	inhibitor	NOUN
bjp-18180	158	21	.	.	PUNCT
bjp-18180	159	1	various	various	ADJ
bjp-18180	159	2	alkylating	alkylate	VERB
bjp-18180	159	3	agents	agent	NOUN
bjp-18180	159	4	,	,	PUNCT
bjp-18180	159	5	nitrogen	nitrogen	NOUN
bjp-18180	159	6	mustered	muster	VERB
bjp-18180	159	7	and	and	CCONJ
bjp-18180	159	8	natural	natural	ADJ
bjp-18180	159	9	anti	anti	ADJ
bjp-18180	159	10	-	-	ADJ
bjp-18180	159	11	cancer	cancer	ADJ
bjp-18180	159	12	molecules	molecule	NOUN
bjp-18180	159	13	have	have	VERB
bjp-18180	159	14	nitrogen	nitrogen	NOUN
bjp-18180	159	15	containing	contain	VERB
bjp-18180	159	16	groups	group	NOUN
bjp-18180	159	17	,	,	PUNCT
bjp-18180	159	18	which	which	PRON
bjp-18180	159	19	generally	generally	ADV
bjp-18180	159	20	interact	interact	VERB
bjp-18180	159	21	with	with	ADP
bjp-18180	159	22	dna/	dna/	PROPN
bjp-18180	159	23	base	base	NOUN
bjp-18180	159	24	pair	pair	NOUN
bjp-18180	159	25	/	/	SYM
bjp-18180	159	26	protein	protein	NOUN
bjp-18180	159	27	and	and	CCONJ
bjp-18180	159	28	alkylate	alkylate	VERB
bjp-18180	159	29	them	they	PRON
bjp-18180	159	30	or	or	CCONJ
bjp-18180	159	31	done	do	VERB
bjp-18180	159	32	other	other	ADJ
bjp-18180	159	33	changes	change	NOUN
bjp-18180	159	34	which	which	PRON
bjp-18180	159	35	ultimately	ultimately	ADV
bjp-18180	159	36	governs	govern	VERB
bjp-18180	159	37	their	their	PRON
bjp-18180	159	38	anti	anti	ADJ
bjp-18180	159	39	-	-	ADJ
bjp-18180	159	40	cancer	cancer	ADJ
bjp-18180	159	41	activity	activity	NOUN
bjp-18180	159	42	.	.	PUNCT
bjp-18180	160	1	nitrogen	nitrogen	NOUN
bjp-18180	160	2	containing	contain	VERB
bjp-18180	160	3	are	be	AUX
bjp-18180	160	4	various	various	ADJ
bjp-18180	160	5	moieties	moiety	NOUN
bjp-18180	160	6	like	like	ADP
bjp-18180	160	7	triazole	triazole	NOUN
bjp-18180	160	8	,	,	PUNCT
bjp-18180	160	9	thiosemicarbazoles	thiosemicarbazole	NOUN
bjp-18180	160	10	and	and	CCONJ
bjp-18180	160	11	nitrosourea	nitrosourea	ADV
bjp-18180	160	12	were	be	AUX
bjp-18180	160	13	used	use	VERB
bjp-18180	160	14	in	in	ADP
bjp-18180	160	15	this	this	DET
bjp-18180	160	16	study	study	NOUN
bjp-18180	160	17	for	for	ADP
bjp-18180	160	18	designing	design	VERB
bjp-18180	160	19	.	.	PUNCT
bjp-18180	161	1	these	these	DET
bjp-18180	161	2	previously	previously	ADV
bjp-18180	161	3	reported	report	VERB
bjp-18180	161	4	results	result	NOUN
bjp-18180	161	5	gives	give	VERB
bjp-18180	161	6	an	an	DET
bjp-18180	161	7	idea	idea	NOUN
bjp-18180	161	8	about	about	ADP
bjp-18180	161	9	designing	design	VERB
bjp-18180	161	10	some	some	DET
bjp-18180	161	11	new	new	ADJ
bjp-18180	161	12	xanthone	xanthone	PROPN
bjp-18180	161	13	based	base	VERB
bjp-18180	161	14	anti	anti	ADJ
bjp-18180	161	15	-	-	ADJ
bjp-18180	161	16	cancer	cancer	ADJ
bjp-18180	161	17	molecules	molecule	NOUN
bjp-18180	161	18	,	,	PUNCT
bjp-18180	161	19	because	because	SCONJ
bjp-18180	161	20	xanthone	xanthone	PROPN
bjp-18180	161	21	moiety	moiety	NOUN
bjp-18180	161	22	shows	show	VERB
bjp-18180	161	23	promising	promise	VERB
bjp-18180	161	24	an	an	DET
bjp-18180	161	25	anti	anti	ADJ
bjp-18180	161	26	-	-	ADJ
bjp-18180	161	27	cancer	cancer	ADJ
bjp-18180	161	28	potential	potential	NOUN
bjp-18180	161	29	,	,	PUNCT
bjp-18180	161	30	proven	prove	VERB
bjp-18180	161	31	through	through	ADP
bjp-18180	161	32	number	number	NOUN
bjp-18180	161	33	of	of	ADP
bjp-18180	161	34	bangladesh	bangladesh	PROPN
bjp-18180	161	35	j	j	PROPN
bjp-18180	161	36	pharmacol	pharmacol	PROPN
bjp-18180	161	37	2014	2014	NUM
bjp-18180	161	38	;	;	PUNCT
bjp-18180	161	39	9	9	NUM
bjp-18180	161	40	:	:	SYM
bjp-18180	161	41	208	208	NUM
bjp-18180	161	42	-	-	SYM
bjp-18180	161	43	217	217	NUM
bjp-18180	161	44	215	215	NUM
bjp-18180	161	45	figure	figure	NOUN
bjp-18180	161	46	4	4	NUM
bjp-18180	161	47	:	:	PUNCT
bjp-18180	161	48	hydrophobic	hydrophobic	NOUN
bjp-18180	161	49	and	and	CCONJ
bjp-18180	161	50	hydrogen	hydrogen	NOUN
bjp-18180	161	51	bond	bond	NOUN
bjp-18180	161	52	forming	forming	NOUN
bjp-18180	161	53	residues	residue	NOUN
bjp-18180	161	54	of	of	ADP
bjp-18180	161	55	the	the	DET
bjp-18180	161	56	docked	docked	ADJ
bjp-18180	161	57	complex	complex	NOUN
bjp-18180	161	58	of	of	ADP
bjp-18180	161	59	xm7	xm7	PROPN
bjp-18180	161	60	and	and	CCONJ
bjp-18180	161	61	the	the	DET
bjp-18180	161	62	model	model	NOUN
bjp-18180	161	63	.	.	PUNCT
bjp-18180	162	1	hydrophobic	hydrophobic	NOUN
bjp-18180	162	2	interactions	interaction	NOUN
bjp-18180	162	3	are	be	AUX
bjp-18180	162	4	shown	show	VERB
bjp-18180	162	5	in	in	ADP
bjp-18180	162	6	red	red	ADJ
bjp-18180	162	7	dotted	dot	VERB
bjp-18180	162	8	line	line	NOUN
bjp-18180	162	9	and	and	CCONJ
bjp-18180	162	10	hydrogen	hydrogen	NOUN
bjp-18180	162	11	bonds	bond	NOUN
bjp-18180	162	12	are	be	AUX
bjp-18180	162	13	shown	show	VERB
bjp-18180	162	14	in	in	ADP
bjp-18180	162	15	green	green	ADJ
bjp-18180	162	16	dotted	dotted	ADJ
bjp-18180	162	17	line	line	NOUN
bjp-18180	162	18	experimental	experimental	ADJ
bjp-18180	162	19	studies	study	NOUN
bjp-18180	162	20	.	.	PUNCT
bjp-18180	163	1	hybrid	hybrid	NOUN
bjp-18180	163	2	based	base	VERB
bjp-18180	163	3	designing	designing	NOUN
bjp-18180	163	4	of	of	ADP
bjp-18180	163	5	new	new	ADJ
bjp-18180	163	6	molecules	molecule	NOUN
bjp-18180	163	7	against	against	ADP
bjp-18180	163	8	various	various	ADJ
bjp-18180	163	9	diseases	disease	NOUN
bjp-18180	163	10	were	be	AUX
bjp-18180	163	11	tried	try	VERB
bjp-18180	163	12	and	and	CCONJ
bjp-18180	163	13	found	find	VERB
bjp-18180	163	14	to	to	PART
bjp-18180	163	15	be	be	AUX
bjp-18180	163	16	much	much	ADV
bjp-18180	163	17	more	more	ADV
bjp-18180	163	18	effective	effective	ADJ
bjp-18180	163	19	,	,	PUNCT
bjp-18180	163	20	as	as	SCONJ
bjp-18180	163	21	compared	compare	VERB
bjp-18180	163	22	to	to	ADP
bjp-18180	163	23	their	their	PRON
bjp-18180	163	24	parent	parent	NOUN
bjp-18180	163	25	molecules	molecule	NOUN
bjp-18180	163	26	.	.	PUNCT
bjp-18180	164	1	through	through	ADP
bjp-18180	164	2	this	this	DET
bjp-18180	164	3	point	point	NOUN
bjp-18180	164	4	of	of	ADP
bjp-18180	164	5	view	view	NOUN
bjp-18180	164	6	,	,	PUNCT
bjp-18180	164	7	few	few	ADJ
bjp-18180	164	8	new	new	ADJ
bjp-18180	164	9	hybrid	hybrid	ADJ
bjp-18180	164	10	molecules	molecule	NOUN
bjp-18180	164	11	were	be	AUX
bjp-18180	164	12	designed	design	VERB
bjp-18180	164	13	and	and	CCONJ
bjp-18180	164	14	docking	dock	VERB
bjp-18180	164	15	studies	study	NOUN
bjp-18180	164	16	were	be	AUX
bjp-18180	164	17	done	do	VERB
bjp-18180	164	18	to	to	PART
bjp-18180	164	19	determine	determine	VERB
bjp-18180	164	20	ligand	ligand	ADJ
bjp-18180	164	21	-	-	PUNCT
bjp-18180	164	22	protein	protein	NOUN
bjp-18180	164	23	interactions	interaction	NOUN
bjp-18180	164	24	.	.	PUNCT
bjp-18180	165	1	drugs	drug	NOUN
bjp-18180	165	2	aimed	aim	VERB
bjp-18180	165	3	against	against	ADP
bjp-18180	165	4	topoisomerases	topoisomerase	NOUN
bjp-18180	165	5	could	could	AUX
bjp-18180	165	6	work	work	VERB
bjp-18180	165	7	by	by	ADP
bjp-18180	165	8	one	one	NUM
bjp-18180	165	9	or	or	CCONJ
bjp-18180	165	10	both	both	PRON
bjp-18180	165	11	of	of	ADP
bjp-18180	165	12	two	two	NUM
bjp-18180	165	13	ways	way	NOUN
bjp-18180	165	14	(	(	PUNCT
bjp-18180	165	15	a	a	NOUN
bjp-18180	165	16	)	)	PUNCT
bjp-18180	165	17	by	by	ADP
bjp-18180	165	18	hindering	hinder	VERB
bjp-18180	165	19	the	the	DET
bjp-18180	165	20	ability	ability	NOUN
bjp-18180	165	21	of	of	ADP
bjp-18180	165	22	the	the	DET
bjp-18180	165	23	enzyme	enzyme	NOUN
bjp-18180	165	24	to	to	PART
bjp-18180	165	25	relieve	relieve	VERB
bjp-18180	165	26	tension	tension	NOUN
bjp-18180	165	27	of	of	ADP
bjp-18180	165	28	dna	dna	NOUN
bjp-18180	165	29	by	by	ADP
bjp-18180	165	30	preventing	prevent	VERB
bjp-18180	165	31	its	its	PRON
bjp-18180	165	32	initial	initial	ADJ
bjp-18180	165	33	cleavage	cleavage	NOUN
bjp-18180	165	34	function	function	NOUN
bjp-18180	165	35	(	(	PUNCT
bjp-18180	165	36	b	b	NOUN
bjp-18180	165	37	)	)	PUNCT
bjp-18180	165	38	by	by	ADP
bjp-18180	165	39	preventing	prevent	VERB
bjp-18180	165	40	relegation	relegation	NOUN
bjp-18180	165	41	of	of	ADP
bjp-18180	165	42	the	the	DET
bjp-18180	165	43	"	"	PUNCT
bjp-18180	165	44	cleavable	cleavable	ADJ
bjp-18180	165	45	complex	complex	NOUN
bjp-18180	165	46	"	"	PUNCT
bjp-18180	165	47	means	mean	VERB
bjp-18180	165	48	stabilizing	stabilize	VERB
bjp-18180	165	49	the	the	DET
bjp-18180	165	50	transient	transient	ADJ
bjp-18180	165	51	cleavable	cleavable	ADJ
bjp-18180	165	52	complex	complex	NOUN
bjp-18180	165	53	,	,	PUNCT
bjp-18180	165	54	results	result	NOUN
bjp-18180	165	55	in	in	ADP
bjp-18180	165	56	enhanced	enhanced	ADJ
bjp-18180	165	57	strand	strand	NOUN
bjp-18180	165	58	breaks	break	NOUN
bjp-18180	165	59	.	.	PUNCT
bjp-18180	166	1	the	the	DET
bjp-18180	166	2	mode	mode	NOUN
bjp-18180	166	3	of	of	ADP
bjp-18180	166	4	action	action	NOUN
bjp-18180	166	5	to	to	PART
bjp-18180	166	6	show	show	VERB
bjp-18180	166	7	cytotoxic	cytotoxic	ADJ
bjp-18180	166	8	behavior	behavior	NOUN
bjp-18180	166	9	for	for	ADP
bjp-18180	166	10	majority	majority	NOUN
bjp-18180	166	11	of	of	ADP
bjp-18180	166	12	topo	topo	PROPN
bjp-18180	166	13	inhibitors	inhibitor	NOUN
bjp-18180	166	14	(	(	PUNCT
bjp-18180	166	15	topo	topo	NOUN
bjp-18180	166	16	poisons	poison	NOUN
bjp-18180	166	17	)	)	PUNCT
bjp-18180	166	18	is	be	AUX
bjp-18180	166	19	just	just	ADV
bjp-18180	166	20	due	due	ADJ
bjp-18180	166	21	to	to	ADP
bjp-18180	166	22	account	account	NOUN
bjp-18180	166	23	of	of	ADP
bjp-18180	166	24	their	their	PRON
bjp-18180	166	25	ability	ability	NOUN
bjp-18180	166	26	to	to	PART
bjp-18180	166	27	stabilizes	stabilizes	VERB
bjp-18180	166	28	a	a	DET
bjp-18180	166	29	transient	transient	ADJ
bjp-18180	166	30	dna	dna	NOUN
bjp-18180	166	31	enzyme	enzyme	NOUN
bjp-18180	166	32	complex	complex	ADJ
bjp-18180	166	33	result	result	NOUN
bjp-18180	166	34	dna	dna	PROPN
bjp-18180	166	35	damage	damage	NOUN
bjp-18180	166	36	thus	thus	ADV
bjp-18180	166	37	produces	produce	VERB
bjp-18180	166	38	detrimental	detrimental	ADJ
bjp-18180	166	39	secondary	secondary	ADJ
bjp-18180	166	40	effects	effect	NOUN
bjp-18180	166	41	.	.	PUNCT
bjp-18180	167	1	the	the	DET
bjp-18180	167	2	structure	structure	NOUN
bjp-18180	167	3	of	of	ADP
bjp-18180	167	4	xanthone	xanthone	PROPN
bjp-18180	167	5	generally	generally	ADV
bjp-18180	167	6	resembles	resemble	VERB
bjp-18180	167	7	more	more	ADV
bjp-18180	167	8	specifically	specifically	ADV
bjp-18180	167	9	to	to	ADP
bjp-18180	167	10	amsacrine	amsacrine	VERB
bjp-18180	167	11	,	,	PUNCT
bjp-18180	167	12	which	which	PRON
bjp-18180	167	13	is	be	AUX
bjp-18180	167	14	a	a	DET
bjp-18180	167	15	known	know	VERB
bjp-18180	167	16	branded	brand	VERB
bjp-18180	167	17	anti	anti	ADJ
bjp-18180	167	18	-	-	ADJ
bjp-18180	167	19	cancer	cancer	ADJ
bjp-18180	167	20	drug	drug	NOUN
bjp-18180	167	21	,	,	PUNCT
bjp-18180	167	22	belongs	belong	VERB
bjp-18180	167	23	to	to	ADP
bjp-18180	167	24	9	9	NUM
bjp-18180	167	25	-	-	PUNCT
bjp-18180	167	26	anilinoacridines	anilinoacridine	NOUN
bjp-18180	167	27	class	class	NOUN
bjp-18180	167	28	of	of	ADP
bjp-18180	167	29	topoisomerase	topoisomerase	PROPN
bjp-18180	167	30	ii	ii	PROPN
bjp-18180	167	31	inhibitors	inhibitor	NOUN
bjp-18180	167	32	,	,	PUNCT
bjp-18180	167	33	having	have	VERB
bjp-18180	167	34	a	a	DET
bjp-18180	167	35	hetero	hetero	VERB
bjp-18180	167	36	-	-	PUNCT
bjp-18180	167	37	tricyclic	tricyclic	ADJ
bjp-18180	167	38	flat	flat	ADJ
bjp-18180	167	39	ring	ring	NOUN
bjp-18180	167	40	system	system	NOUN
bjp-18180	167	41	.	.	PUNCT
bjp-18180	168	1	xanthone	xanthone	PROPN
bjp-18180	168	2	may	may	AUX
bjp-18180	168	3	act	act	VERB
bjp-18180	168	4	via	via	ADP
bjp-18180	168	5	same	same	ADJ
bjp-18180	168	6	mechanism	mechanism	NOUN
bjp-18180	168	7	as	as	ADP
bjp-18180	168	8	9	9	NUM
bjp-18180	168	9	-	-	PUNCT
bjp-18180	168	10	anilinoacridines	anilinoacridine	NOUN
bjp-18180	168	11	because	because	SCONJ
bjp-18180	168	12	of	of	ADP
bjp-18180	168	13	too	too	ADV
bjp-18180	168	14	much	much	ADJ
bjp-18180	168	15	similarity	similarity	NOUN
bjp-18180	168	16	in	in	ADP
bjp-18180	168	17	theirstructure	theirstructure	NOUN
bjp-18180	168	18	.	.	PUNCT
bjp-18180	169	1	the	the	DET
bjp-18180	169	2	cytotoxicity	cytotoxicity	NOUN
bjp-18180	169	3	shown	show	VERB
bjp-18180	169	4	by	by	ADP
bjp-18180	169	5	these	these	DET
bjp-18180	169	6	compounds	compound	NOUN
bjp-18180	169	7	,	,	PUNCT
bjp-18180	169	8	primarily	primarily	ADV
bjp-18180	169	9	results	result	VERB
bjp-18180	169	10	due	due	ADJ
bjp-18180	169	11	to	to	ADP
bjp-18180	169	12	inhibition	inhibition	NOUN
bjp-18180	169	13	of	of	ADP
bjp-18180	169	14	topo	topo	PROPN
bjp-18180	169	15	ii	ii	PROPN
bjp-18180	169	16	through	through	ADP
bjp-18180	169	17	formation	formation	NOUN
bjp-18180	169	18	of	of	ADP
bjp-18180	169	19	a	a	DET
bjp-18180	169	20	ternary	ternary	ADJ
bjp-18180	169	21	drug	drug	NOUN
bjp-18180	169	22	/	/	SYM
bjp-18180	169	23	dna	dna	NOUN
bjp-18180	169	24	/	/	SYM
bjp-18180	169	25	protein	protein	NOUN
bjp-18180	169	26	complex	complex	NOUN
bjp-18180	169	27	(	(	PUNCT
bjp-18180	169	28	liu	liu	PROPN
bjp-18180	169	29	,	,	PUNCT
bjp-18180	169	30	1989	1989	NUM
bjp-18180	169	31	;	;	PUNCT
bjp-18180	169	32	robinson	robinson	PROPN
bjp-18180	169	33	and	and	CCONJ
bjp-18180	169	34	osheroff	osheroff	NOUN
bjp-18180	169	35	,	,	PUNCT
bjp-18180	169	36	1991	1991	NUM
bjp-18180	169	37	)	)	PUNCT
bjp-18180	169	38	gave	give	VERB
bjp-18180	169	39	a	a	DET
bjp-18180	169	40	clear	clear	ADJ
bjp-18180	169	41	picture	picture	NOUN
bjp-18180	169	42	that	that	SCONJ
bjp-18180	169	43	drug	drug	NOUN
bjp-18180	169	44	design	design	NOUN
bjp-18180	169	45	through	through	ADP
bjp-18180	169	46	modeling	modeling	NOUN
bjp-18180	169	47	of	of	ADP
bjp-18180	169	48	dna	dna	NOUN
bjp-18180	169	49	binding	bind	VERB
bjp-18180	169	50	properties	property	NOUN
bjp-18180	169	51	alone	alone	ADV
bjp-18180	169	52	could	could	AUX
bjp-18180	169	53	be	be	AUX
bjp-18180	169	54	misleading	misleading	ADJ
bjp-18180	169	55	.	.	PUNCT
bjp-18180	170	1	the	the	DET
bjp-18180	170	2	antitumor	antitumor	PROPN
bjp-18180	170	3	activity	activity	NOUN
bjp-18180	170	4	of	of	ADP
bjp-18180	170	5	these	these	DET
bjp-18180	170	6	drugs	drug	NOUN
bjp-18180	170	7	governed	govern	VERB
bjp-18180	170	8	mostly	mostly	ADV
bjp-18180	170	9	,	,	PUNCT
bjp-18180	170	10	just	just	ADV
bjp-18180	170	11	because	because	SCONJ
bjp-18180	170	12	of	of	ADP
bjp-18180	170	13	their	their	PRON
bjp-18180	170	14	proper	proper	ADJ
bjp-18180	170	15	positioning	positioning	NOUN
bjp-18180	170	16	and	and	CCONJ
bjp-18180	170	17	stabilization	stabilization	NOUN
bjp-18180	170	18	of	of	ADP
bjp-18180	170	19	the	the	DET
bjp-18180	170	20	drug	drug	NOUN
bjp-18180	170	21	at	at	ADP
bjp-18180	170	22	its	its	PRON
bjp-18180	170	23	binding	bind	VERB
bjp-18180	170	24	domain	domain	NOUN
bjp-18180	170	25	,	,	PUNCT
bjp-18180	170	26	than	than	ADP
bjp-18180	170	27	its	its	PRON
bjp-18180	170	28	(	(	PUNCT
bjp-18180	170	29	ligand	ligand	ADJ
bjp-18180	170	30	or	or	CCONJ
bjp-18180	170	31	drug	drug	NOUN
bjp-18180	170	32	)	)	PUNCT
bjp-18180	170	33	actual	actual	ADJ
bjp-18180	170	34	affinity	affinity	NOUN
bjp-18180	170	35	for	for	ADP
bjp-18180	170	36	dna	dna	PROPN
bjp-18180	170	37	(	(	PUNCT
bjp-18180	170	38	binaschi	binaschi	PROPN
bjp-18180	170	39	et	et	PROPN
bjp-18180	170	40	al	al	PROPN
bjp-18180	170	41	.	.	PROPN
bjp-18180	170	42	,	,	PUNCT
bjp-18180	170	43	2001	2001	NUM
bjp-18180	170	44	;	;	PUNCT
bjp-18180	170	45	patil	patil	PROPN
bjp-18180	170	46	and	and	CCONJ
bjp-18180	170	47	thakare	thakare	NOUN
bjp-18180	170	48	,	,	PUNCT
bjp-18180	170	49	2012	2012	NUM
bjp-18180	170	50	)	)	PUNCT
bjp-18180	170	51	.	.	PUNCT
bjp-18180	171	1	among	among	ADP
bjp-18180	171	2	11	11	NUM
bjp-18180	171	3	compounds	compound	NOUN
bjp-18180	171	4	xm7	xm7	NOUN
bjp-18180	171	5	binds	bind	VERB
bjp-18180	171	6	in	in	ADP
bjp-18180	171	7	same	same	ADJ
bjp-18180	171	8	pocket	pocket	NOUN
bjp-18180	171	9	and	and	CCONJ
bjp-18180	171	10	also	also	ADV
bjp-18180	171	11	interacts	interact	VERB
bjp-18180	171	12	with	with	ADP
bjp-18180	171	13	same	same	ADJ
bjp-18180	171	14	residues	residue	NOUN
bjp-18180	171	15	of	of	ADP
bjp-18180	171	16	topoisomerase	topoisomerase	NOUN
bjp-18180	171	17	ii	ii	NOUN
bjp-18180	171	18	where	where	SCONJ
bjp-18180	171	19	cucumarioside	cucumarioside	VERB
bjp-18180	171	20	a	a	PRON
bjp-18180	171	21	,	,	PUNCT
bjp-18180	171	22	holothurinoside	holothurinoside	NOUN
bjp-18180	171	23	a	a	PRON
bjp-18180	171	24	,	,	PUNCT
bjp-18180	171	25	holothurin	holothurin	NOUN
bjp-18180	171	26	a	a	X
bjp-18180	171	27	,	,	PUNCT
bjp-18180	171	28	bivittoside	bivittoside	VERB
bjp-18180	171	29	a	a	PRON
bjp-18180	171	30	and	and	CCONJ
bjp-18180	171	31	holotoxin	holotoxin	ADJ
bjp-18180	171	32	a	a	PRON
bjp-18180	171	33	were	be	AUX
bjp-18180	171	34	found	find	VERB
bjp-18180	171	35	to	to	PART
bjp-18180	171	36	be	be	AUX
bjp-18180	171	37	bounded	bound	VERB
bjp-18180	171	38	which	which	PRON
bjp-18180	171	39	were	be	AUX
bjp-18180	171	40	founded	found	VERB
bjp-18180	171	41	to	to	PART
bjp-18180	171	42	be	be	AUX
bjp-18180	171	43	more	more	ADV
bjp-18180	171	44	potent	potent	ADJ
bjp-18180	171	45	than	than	ADP
bjp-18180	171	46	etoposide	etoposide	NOUN
bjp-18180	171	47	as	as	SCONJ
bjp-18180	171	48	previously	previously	ADV
bjp-18180	171	49	reported	report	VERB
bjp-18180	171	50	.	.	PUNCT
bjp-18180	172	1	the	the	DET
bjp-18180	172	2	new	new	ADJ
bjp-18180	172	3	hybrid	hybrid	NOUN
bjp-18180	172	4	compound	compound	NOUN
bjp-18180	172	5	xm7	xm7	NOUN
bjp-18180	173	1	having	have	VERB
bjp-18180	173	2	a	a	DET
bjp-18180	173	3	simple	simple	ADJ
bjp-18180	173	4	primary	primary	ADJ
bjp-18180	173	5	structure	structure	NOUN
bjp-18180	173	6	and	and	CCONJ
bjp-18180	173	7	more	more	ADJ
bjp-18180	173	8	potential	potential	ADJ
bjp-18180	173	9	candidate	candidate	NOUN
bjp-18180	173	10	with	with	ADP
bjp-18180	173	11	having	have	VERB
bjp-18180	173	12	binding	bind	VERB
bjp-18180	173	13	energy	energy	NOUN
bjp-18180	173	14	of	of	ADP
bjp-18180	173	15	about	about	ADV
bjp-18180	173	16	-12.7	-12.7	NUM
bjp-18180	173	17	kcal	kcal	NOUN
bjp-18180	173	18	/	/	SYM
bjp-18180	173	19	mol	mol	NOUN
bjp-18180	173	20	than	than	ADP
bjp-18180	173	21	some	some	DET
bjp-18180	173	22	naturally	naturally	ADV
bjp-18180	173	23	occurring	occur	VERB
bjp-18180	173	24	marine	marine	ADJ
bjp-18180	173	25	agents	agent	NOUN
bjp-18180	173	26	used	use	VERB
bjp-18180	173	27	as	as	ADP
bjp-18180	173	28	an	an	DET
bjp-18180	173	29	anti	anti	ADJ
bjp-18180	173	30	-	-	ADJ
bjp-18180	173	31	cancer	cancer	ADJ
bjp-18180	173	32	agents	agent	NOUN
bjp-18180	173	33	with	with	ADP
bjp-18180	173	34	more	more	ADJ
bjp-18180	173	35	complex	complex	ADJ
bjp-18180	173	36	chemical	chemical	NOUN
bjp-18180	173	37	structures	structure	NOUN
bjp-18180	173	38	and	and	CCONJ
bjp-18180	173	39	interact	interact	VERB
bjp-18180	173	40	with	with	ADP
bjp-18180	173	41	the	the	DET
bjp-18180	173	42	most	most	ADV
bjp-18180	173	43	potential	potential	ADJ
bjp-18180	173	44	active	active	ADJ
bjp-18180	173	45	site	site	NOUN
bjp-18180	173	46	,	,	PUNCT
bjp-18180	173	47	considered	consider	VERB
bjp-18180	173	48	(	(	PUNCT
bjp-18180	173	49	patil	patil	NOUN
bjp-18180	173	50	and	and	CCONJ
bjp-18180	173	51	thakare	thakare	NOUN
bjp-18180	173	52	,	,	PUNCT
bjp-18180	173	53	2012	2012	NUM
bjp-18180	173	54	)	)	PUNCT
bjp-18180	173	55	.	.	PUNCT
bjp-18180	174	1	however	however	ADV
bjp-18180	174	2	,	,	PUNCT
bjp-18180	174	3	five	five	NUM
bjp-18180	174	4	compounds	compound	NOUN
bjp-18180	174	5	out	out	ADP
bjp-18180	174	6	of	of	ADP
bjp-18180	174	7	11	11	NUM
bjp-18180	174	8	compound	compound	NOUN
bjp-18180	174	9	possesses	possesse	NOUN
bjp-18180	174	10	lowest	low	ADJ
bjp-18180	174	11	binding	bind	VERB
bjp-18180	174	12	energy	energy	NOUN
bjp-18180	174	13	below	below	ADP
bjp-18180	174	14	-11.1	-11.1	PROPN
bjp-18180	174	15	kcal	kcal	PROPN
bjp-18180	174	16	/	/	SYM
bjp-18180	174	17	mol	mol	PROPN
bjp-18180	174	18	.	.	PROPN
bjp-18180	175	1	admet	admet	PROPN
bjp-18180	175	2	screening	screen	VERB
bjp-18180	175	3	provided	provide	VERB
bjp-18180	175	4	a	a	DET
bjp-18180	175	5	clear	clear	ADJ
bjp-18180	175	6	cut	cut	ADJ
bjp-18180	175	7	picture	picture	NOUN
bjp-18180	175	8	about	about	ADP
bjp-18180	175	9	candidates	candidate	NOUN
bjp-18180	175	10	under	under	ADP
bjp-18180	175	11	consideration	consideration	NOUN
bjp-18180	175	12	and	and	CCONJ
bjp-18180	175	13	suggests	suggest	VERB
bjp-18180	175	14	for	for	ADP
bjp-18180	175	15	further	further	ADJ
bjp-18180	175	16	modifications	modification	NOUN
bjp-18180	175	17	in	in	ADP
bjp-18180	175	18	following	follow	VERB
bjp-18180	175	19	candidates	candidate	NOUN
bjp-18180	175	20	.	.	PUNCT
bjp-18180	176	1	study	study	NOUN
bjp-18180	176	2	gives	give	VERB
bjp-18180	176	3	an	an	DET
bjp-18180	176	4	opinion	opinion	NOUN
bjp-18180	176	5	that	that	SCONJ
bjp-18180	176	6	the	the	DET
bjp-18180	176	7	designed	design	VERB
bjp-18180	176	8	molecules	molecule	NOUN
bjp-18180	176	9	require	require	VERB
bjp-18180	176	10	further	further	ADJ
bjp-18180	176	11	modifications	modification	NOUN
bjp-18180	176	12	to	to	PART
bjp-18180	176	13	improve	improve	VERB
bjp-18180	176	14	drug	drug	NOUN
bjp-18180	176	15	-	-	PUNCT
bjp-18180	176	16	receptor	receptor	NOUN
bjp-18180	176	17	interactions	interaction	NOUN
bjp-18180	176	18	.	.	PUNCT
bjp-18180	177	1	however	however	ADV
bjp-18180	177	2	binding	bind	VERB
bjp-18180	177	3	energy	energy	NOUN
bjp-18180	177	4	data	datum	NOUN
bjp-18180	177	5	and	and	CCONJ
bjp-18180	177	6	docking	docking	NOUN
bjp-18180	177	7	studies	study	NOUN
bjp-18180	177	8	revealed	reveal	VERB
bjp-18180	177	9	,	,	PUNCT
bjp-18180	177	10	a	a	DET
bjp-18180	177	11	good	good	ADJ
bjp-18180	177	12	picture	picture	NOUN
bjp-18180	177	13	of	of	ADP
bjp-18180	177	14	compounds	compound	NOUN
bjp-18180	177	15	affinity	affinity	NOUN
bjp-18180	177	16	and	and	CCONJ
bjp-18180	177	17	fitting	fitting	ADJ
bjp-18180	177	18	inside	inside	ADP
bjp-18180	177	19	the	the	DET
bjp-18180	177	20	binding	bind	VERB
bjp-18180	177	21	pocket	pocket	NOUN
bjp-18180	177	22	.	.	PUNCT
bjp-18180	178	1	docking	dock	VERB
bjp-18180	178	2	studies	study	NOUN
bjp-18180	178	3	also	also	ADV
bjp-18180	178	4	revealed	reveal	VERB
bjp-18180	178	5	the	the	DET
bjp-18180	178	6	mode	mode	NOUN
bjp-18180	178	7	of	of	ADP
bjp-18180	178	8	binding	bind	VERB
bjp-18180	178	9	of	of	ADP
bjp-18180	178	10	new	new	ADJ
bjp-18180	178	11	novel	novel	ADJ
bjp-18180	178	12	hybrid	hybrid	ADJ
bjp-18180	178	13	xanthones	xanthone	NOUN
bjp-18180	178	14	into	into	ADP
bjp-18180	178	15	the	the	DET
bjp-18180	178	16	binding	bind	VERB
bjp-18180	178	17	pocket	pocket	NOUN
bjp-18180	178	18	of	of	ADP
bjp-18180	178	19	topo	topo	PROPN
bjp-18180	178	20	ii	ii	PROPN
bjp-18180	178	21	.	.	PUNCT
bjp-18180	179	1	the	the	DET
bjp-18180	179	2	designed	design	VERB
bjp-18180	179	3	compounds	compound	NOUN
bjp-18180	179	4	will	will	AUX
bjp-18180	179	5	be	be	AUX
bjp-18180	179	6	synthesized	synthesize	VERB
bjp-18180	179	7	and	and	CCONJ
bjp-18180	179	8	evaluated	evaluate	VERB
bjp-18180	179	9	for	for	ADP
bjp-18180	179	10	their	their	PRON
bjp-18180	179	11	anti	anti	ADJ
bjp-18180	179	12	-	-	ADJ
bjp-18180	179	13	cancer	cancer	ADJ
bjp-18180	179	14	potential	potential	NOUN
bjp-18180	179	15	.	.	PUNCT
bjp-18180	180	1	all	all	DET
bjp-18180	180	2	designed	design	VERB
bjp-18180	180	3	compounds	compound	NOUN
bjp-18180	180	4	are	be	AUX
bjp-18180	180	5	under	under	ADP
bjp-18180	180	6	further	further	ADJ
bjp-18180	180	7	modification	modification	NOUN
bjp-18180	180	8	to	to	PART
bjp-18180	180	9	generate	generate	VERB
bjp-18180	180	10	an	an	DET
bjp-18180	180	11	ultimate	ultimate	ADJ
bjp-18180	180	12	molecule	molecule	NOUN
bjp-18180	180	13	with	with	ADP
bjp-18180	180	14	desired	desire	VERB
bjp-18180	180	15	activity	activity	NOUN
bjp-18180	180	16	and	and	CCONJ
bjp-18180	180	17	safety	safety	NOUN
bjp-18180	180	18	profile	profile	NOUN
bjp-18180	180	19	.	.	PUNCT
bjp-18180	181	1	216	216	NUM
bjp-18180	181	2	bangladesh	bangladesh	PROPN
bjp-18180	181	3	j	j	PROPN
bjp-18180	181	4	pharmacol	pharmacol	PROPN
bjp-18180	181	5	2014	2014	NUM
bjp-18180	181	6	;	;	PUNCT
bjp-18180	181	7	9	9	NUM
bjp-18180	181	8	:	:	SYM
bjp-18180	181	9	208	208	NUM
bjp-18180	181	10	-	-	SYM
bjp-18180	181	11	217	217	NUM
bjp-18180	181	12	figure	figure	NOUN
bjp-18180	181	13	5	5	NUM
bjp-18180	181	14	:	:	PUNCT
bjp-18180	181	15	the	the	DET
bjp-18180	181	16	polar	polar	ADJ
bjp-18180	181	17	contacts	contact	NOUN
bjp-18180	181	18	of	of	ADP
bjp-18180	181	19	the	the	DET
bjp-18180	181	20	compound	compound	NOUN
bjp-18180	181	21	xm7	xm7	NOUN
bjp-18180	181	22	with	with	ADP
bjp-18180	181	23	the	the	DET
bjp-18180	181	24	binding	bind	VERB
bjp-18180	181	25	site	site	NOUN
bjp-18180	181	26	of	of	ADP
bjp-18180	181	27	the	the	DET
bjp-18180	181	28	modeled	model	VERB
bjp-18180	181	29	protein	protein	NOUN
bjp-18180	181	30	.	.	PUNCT
bjp-18180	182	1	the	the	DET
bjp-18180	182	2	yellow	yellow	ADJ
bjp-18180	182	3	dotted	dotted	ADJ
bjp-18180	182	4	line	line	NOUN
bjp-18180	182	5	shows	show	VERB
bjp-18180	182	6	the	the	DET
bjp-18180	182	7	polar	polar	ADJ
bjp-18180	182	8	contacts	contact	NOUN
bjp-18180	182	9	formed	form	VERB
bjp-18180	182	10	and	and	CCONJ
bjp-18180	182	11	were	be	AUX
bjp-18180	182	12	found	find	VERB
bjp-18180	182	13	to	to	PART
bjp-18180	182	14	be	be	AUX
bjp-18180	182	15	asn770	asn770	PROPN
bjp-18180	182	16	and	and	CCONJ
bjp-18180	182	17	lys	lys	VERB
bjp-18180	182	18	798	798	NUM
bjp-18180	182	19	bangladesh	bangladesh	NOUN
bjp-18180	182	20	j	j	PROPN
bjp-18180	182	21	pharmacol	pharmacol	PROPN
bjp-18180	182	22	2014	2014	NUM
bjp-18180	182	23	;	;	PUNCT
bjp-18180	182	24	9	9	NUM
bjp-18180	182	25	:	:	SYM
bjp-18180	182	26	208	208	NUM
bjp-18180	182	27	-	-	SYM
bjp-18180	182	28	217	217	NUM
bjp-18180	182	29	217	217	NUM
bjp-18180	182	30	author	author	NOUN
bjp-18180	182	31	info	info	NOUN
bjp-18180	182	32	pratap	pratap	PROPN
bjp-18180	182	33	parida	parida	PROPN
bjp-18180	182	34	(	(	PUNCT
bjp-18180	182	35	principal	principal	ADJ
bjp-18180	182	36	contact	contact	NOUN
bjp-18180	182	37	)	)	PUNCT
bjp-18180	183	1	e	e	NOUN
bjp-18180	183	2	-	-	NOUN
bjp-18180	183	3	mail	mail	NOUN
bjp-18180	183	4	:	:	PUNCT
bjp-18180	183	5	pratapparida2007yahoo.com	pratapparida2007yahoo.com	X
bjp-18180	183	6	@gmail.com	@gmail.com	X
bjp-18180	183	7	all	all	DET
bjp-18180	183	8	11	11	NUM
bjp-18180	183	9	candidates	candidate	NOUN
bjp-18180	183	10	were	be	AUX
bjp-18180	183	11	found	find	VERB
bjp-18180	183	12	to	to	PART
bjp-18180	183	13	be	be	AUX
bjp-18180	183	14	showing	show	VERB
bjp-18180	183	15	excellent	excellent	ADJ
bjp-18180	183	16	activity	activity	NOUN
bjp-18180	183	17	,	,	PUNCT
bjp-18180	183	18	out	out	ADP
bjp-18180	183	19	of	of	ADP
bjp-18180	183	20	which	which	PRON
bjp-18180	183	21	three	three	NUM
bjp-18180	183	22	candidates	candidate	NOUN
bjp-18180	183	23	were	be	AUX
bjp-18180	183	24	found	find	VERB
bjp-18180	183	25	to	to	PART
bjp-18180	183	26	be	be	AUX
bjp-18180	183	27	more	more	ADV
bjp-18180	183	28	potent	potent	ADJ
bjp-18180	183	29	than	than	ADP
bjp-18180	183	30	previously	previously	ADV
bjp-18180	183	31	reported	report	VERB
bjp-18180	183	32	candidates	candidate	NOUN
bjp-18180	183	33	as	as	ADP
bjp-18180	183	34	an	an	DET
bjp-18180	183	35	anti	anti	ADJ
bjp-18180	183	36	-	-	ADJ
bjp-18180	183	37	cancer	cancer	ADJ
bjp-18180	183	38	agent	agent	NOUN
bjp-18180	183	39	.	.	PUNCT
bjp-18180	184	1	compound	compound	NOUN
bjp-18180	184	2	xm7	xm7	PROPN
bjp-18180	184	3	was	be	AUX
bjp-18180	184	4	found	find	VERB
bjp-18180	184	5	to	to	PART
bjp-18180	184	6	be	be	AUX
bjp-18180	184	7	interacting	interact	VERB
bjp-18180	184	8	with	with	ADP
bjp-18180	184	9	pro803	pro803	PROPN
bjp-18180	184	10	,	,	PUNCT
bjp-18180	184	11	ser800	ser800	PROPN
bjp-18180	184	12	,	,	PUNCT
bjp-18180	184	13	iie769	iie769	NOUN
bjp-18180	184	14	,	,	PUNCT
bjp-18180	184	15	gln773	gln773	PROPN
bjp-18180	184	16	,	,	PUNCT
bjp-18180	184	17	gly797	gly797	PROPN
bjp-18180	184	18	,	,	PUNCT
bjp-18180	184	19	gly796	gly796	PROPN
bjp-18180	184	20	,	,	PUNCT
bjp-18180	184	21	asn770	asn770	PROPN
bjp-18180	184	22	,	,	PUNCT
bjp-18180	184	23	lys798	lys798	PROPN
bjp-18180	184	24	,	,	PUNCT
bjp-18180	184	25	met766	met766	NOUN
bjp-18180	184	26	and	and	CCONJ
bjp-18180	184	27	met762	met762	PROPN
bjp-18180	184	28	,	,	PUNCT
bjp-18180	184	29	which	which	PRON
bjp-18180	184	30	was	be	AUX
bjp-18180	184	31	previously	previously	ADV
bjp-18180	184	32	reported	report	VERB
bjp-18180	184	33	to	to	PART
bjp-18180	184	34	constitute	constitute	VERB
bjp-18180	184	35	the	the	DET
bjp-18180	184	36	most	most	ADV
bjp-18180	184	37	active	active	ADJ
bjp-18180	184	38	site	site	NOUN
bjp-18180	184	39	of	of	ADP
bjp-18180	184	40	human	human	PROPN
bjp-18180	184	41	dna	dna	PROPN
bjp-18180	184	42	topoisomerase	topoisomerase	PROPN
bjp-18180	184	43	ii	ii	PROPN
bjp-18180	184	44	,	,	PUNCT
bjp-18180	184	45	through	through	ADP
bjp-18180	184	46	which	which	PRON
bjp-18180	184	47	various	various	ADJ
bjp-18180	184	48	marine	marine	NOUN
bjp-18180	184	49	based	base	VERB
bjp-18180	184	50	anti	anti	ADJ
bjp-18180	184	51	-	-	ADJ
bjp-18180	184	52	cancer	cancer	ADJ
bjp-18180	184	53	triterpeneglycosides	triterpeneglycoside	NOUN
bjp-18180	184	54	like	like	INTJ
bjp-18180	184	55	cucumarioside	cucumarioside	VERB
bjp-18180	184	56	a	a	PRON
bjp-18180	184	57	,	,	PUNCT
bjp-18180	184	58	holothurinoside	holothurinoside	NOUN
bjp-18180	184	59	a	a	PRON
bjp-18180	184	60	,	,	PUNCT
bjp-18180	184	61	holothurin	holothurin	NOUN
bjp-18180	184	62	a	a	X
bjp-18180	184	63	,	,	PUNCT
bjp-18180	184	64	bivittoside	bivittoside	NOUN
bjp-18180	184	65	a	a	PRON
bjp-18180	184	66	,	,	PUNCT
bjp-18180	184	67	holotoxin	holotoxin	ADJ
bjp-18180	184	68	a	a	DET
bjp-18180	184	69	acts	act	NOUN
bjp-18180	184	70	(	(	PUNCT
bjp-18180	184	71	patil	patil	NOUN
bjp-18180	184	72	and	and	CCONJ
bjp-18180	184	73	thakare	thakare	NOUN
bjp-18180	184	74	,	,	PUNCT
bjp-18180	184	75	2012	2012	NUM
bjp-18180	184	76	)	)	PUNCT
bjp-18180	184	77	.	.	PUNCT
bjp-18180	185	1	thus	thus	ADV
bjp-18180	185	2	we	we	PRON
bjp-18180	185	3	could	could	AUX
bjp-18180	185	4	conclude	conclude	VERB
bjp-18180	185	5	through	through	ADP
bjp-18180	185	6	these	these	DET
bjp-18180	185	7	docking	dock	VERB
bjp-18180	185	8	studies	study	NOUN
bjp-18180	185	9	that	that	SCONJ
bjp-18180	185	10	five	five	NUM
bjp-18180	185	11	compoundsxm9	compoundsxm9	NOUN
bjp-18180	185	12	,	,	PUNCT
bjp-18180	185	13	xn2	xn2	PROPN
bjp-18180	185	14	,	,	PUNCT
bjp-18180	185	15	xm7	xm7	PROPN
bjp-18180	185	16	,	,	PUNCT
bjp-18180	185	17	xlnu	xlnu	PROPN
bjp-18180	185	18	and	and	CCONJ
bjp-18180	185	19	xns	xns	PROPN
bjp-18180	185	20	could	could	AUX
bjp-18180	185	21	be	be	AUX
bjp-18180	185	22	act	act	NOUN
bjp-18180	185	23	as	as	ADP
bjp-18180	185	24	a	a	DET
bjp-18180	185	25	potential	potential	ADJ
bjp-18180	185	26	lead	lead	NOUN
bjp-18180	185	27	to	to	PART
bjp-18180	185	28	evolve	evolve	VERB
bjp-18180	185	29	a	a	DET
bjp-18180	185	30	potential	potential	ADJ
bjp-18180	185	31	anti	anti	ADJ
bjp-18180	185	32	-	-	ADJ
bjp-18180	185	33	cancer	cancer	ADJ
bjp-18180	185	34	candidate	candidate	NOUN
bjp-18180	185	35	against	against	ADP
bjp-18180	185	36	human	human	ADJ
bjp-18180	185	37	dna	dna	PROPN
bjp-18180	185	38	topoisomerase	topoisomerase	PROPN
bjp-18180	185	39	ii	ii	PROPN
bjp-18180	185	40	inhibitors	inhibitor	NOUN
bjp-18180	185	41	.	.	PUNCT
bjp-18180	186	1	acknowledgement	acknowledgement	NOUN
bjp-18180	186	2	the	the	DET
bjp-18180	186	3	authors	author	NOUN
bjp-18180	186	4	gratefully	gratefully	ADV
bjp-18180	186	5	acknowledge	acknowledge	VERB
bjp-18180	186	6	bioinformatics	bioinformatics	NOUN
bjp-18180	186	7	infrastructure	infrastructure	NOUN
bjp-18180	186	8	facility	facility	NOUN
bjp-18180	186	9	(	(	PUNCT
bjp-18180	186	10	bif	bif	NOUN
bjp-18180	186	11	)	)	PUNCT
bjp-18180	186	12	funded	fund	VERB
bjp-18180	186	13	by	by	ADP
bjp-18180	186	14	department	department	NOUN
bjp-18180	186	15	of	of	ADP
bjp-18180	186	16	biotechnology	biotechnology	NOUN
bjp-18180	186	17	,	,	PUNCT
bjp-18180	186	18	govt	govt	PROPN
bjp-18180	186	19	.	.	PUNCT
bjp-18180	187	1	of	of	ADP
bjp-18180	187	2	india	india	PROPN
bjp-18180	187	3	,	,	PUNCT
bjp-18180	187	4	at	at	ADP
bjp-18180	187	5	centre	centre	NOUN
bjp-18180	187	6	for	for	ADP
bjp-18180	187	7	studies	study	NOUN
bjp-18180	187	8	in	in	ADP
bjp-18180	187	9	biotechnology	biotechnology	NOUN
bjp-18180	187	10	,	,	PUNCT
bjp-18180	187	11	dibrugarh	dibrugarh	NOUN
bjp-18180	187	12	university	university	NOUN
bjp-18180	187	13	.	.	PUNCT
bjp-18180	188	1	references	reference	NOUN
bjp-18180	188	2	bailly	bailly	PROPN
bjp-18180	188	3	c.	c.	PROPN
bjp-18180	188	4	contemporary	contemporary	ADJ
bjp-18180	188	5	challenges	challenge	NOUN
bjp-18180	188	6	in	in	ADP
bjp-18180	188	7	the	the	DET
bjp-18180	188	8	design	design	NOUN
bjp-18180	188	9	of	of	ADP
bjp-18180	188	10	topoisomerase	topoisomerase	ADJ
bjp-18180	188	11	ii	ii	NOUN
bjp-18180	188	12	inhibitors	inhibitor	NOUN
bjp-18180	188	13	for	for	ADP
bjp-18180	188	14	cancer	cancer	NOUN
bjp-18180	188	15	chemotherapy	chemotherapy	NOUN
bjp-18180	188	16	.	.	PUNCT
bjp-18180	189	1	chem	chem	PROPN
bjp-18180	189	2	rev	rev	VERB
bjp-18180	189	3	.	.	PROPN
bjp-18180	189	4	2012	2012	NUM
bjp-18180	189	5	;	;	PUNCT
bjp-18180	189	6	112	112	NUM
bjp-18180	189	7	:	:	PUNCT
bjp-18180	189	8	3611	3611	NUM
bjp-18180	189	9	-	-	SYM
bjp-18180	189	10	40	40	NUM
bjp-18180	189	11	.	.	PUNCT
bjp-18180	190	1	binaschi	binaschi	PROPN
bjp-18180	190	2	m	m	PROPN
bjp-18180	190	3	,	,	PUNCT
bjp-18180	190	4	bigioni	bigioni	PROPN
bjp-18180	190	5	m	m	PROPN
bjp-18180	190	6	,	,	PUNCT
bjp-18180	190	7	cipollone	cipollone	NOUN
bjp-18180	190	8	a	a	PRON
bjp-18180	190	9	,	,	PUNCT
bjp-18180	190	10	rossi	rossi	ADJ
bjp-18180	190	11	c	c	NOUN
bjp-18180	190	12	,	,	PUNCT
bjp-18180	190	13	goso	goso	NOUN
bjp-18180	190	14	c	c	X
bjp-18180	190	15	,	,	PUNCT
bjp-18180	190	16	maggi	maggi	PROPN
bjp-18180	190	17	ca	can	AUX
bjp-18180	190	18	,	,	PUNCT
bjp-18180	190	19	capranico	capranico	NOUN
bjp-18180	190	20	g	g	PROPN
bjp-18180	190	21	,	,	PUNCT
bjp-18180	190	22	animati	animati	PROPN
bjp-18180	190	23	f.	f.	PROPN
bjp-18180	190	24	anthracyclines	anthracyclines	PROPN
bjp-18180	190	25	:	:	PUNCT
bjp-18180	190	26	selected	select	VERB
bjp-18180	190	27	new	new	ADJ
bjp-18180	190	28	developments	development	NOUN
bjp-18180	190	29	.	.	PUNCT
bjp-18180	191	1	curr	curr	PROPN
bjp-18180	191	2	med	med	PROPN
bjp-18180	191	3	chem	chem	NOUN
bjp-18180	191	4	anti	anti	ADJ
bjp-18180	191	5	-	-	ADJ
bjp-18180	191	6	cancer	cancer	ADJ
bjp-18180	191	7	agents	agent	NOUN
bjp-18180	191	8	.	.	PUNCT
bjp-18180	192	1	2001	2001	NUM
bjp-18180	192	2	;	;	PUNCT
bjp-18180	192	3	1	1	NUM
bjp-18180	192	4	:	:	SYM
bjp-18180	192	5	113	113	NUM
bjp-18180	192	6	-	-	SYM
bjp-18180	192	7	30	30	NUM
bjp-18180	192	8	.	.	PUNCT
bjp-18180	193	1	boehm	boehm	PROPN
bjp-18180	193	2	hj	hj	PROPN
bjp-18180	193	3	,	,	PUNCT
bjp-18180	193	4	boehringer	boehringer	PROPN
bjp-18180	193	5	m	m	PROPN
bjp-18180	193	6	,	,	PUNCT
bjp-18180	193	7	bur	bur	PROPN
bjp-18180	193	8	d	d	PROPN
bjp-18180	193	9	,	,	PUNCT
bjp-18180	193	10	gmuender	gmuender	PROPN
bjp-18180	193	11	h	h	PROPN
bjp-18180	193	12	,	,	PUNCT
bjp-18180	193	13	huber	huber	PROPN
bjp-18180	193	14	w	w	PROPN
bjp-18180	193	15	,	,	PUNCT
bjp-18180	193	16	klaus	klaus	PROPN
bjp-18180	193	17	w	w	PROPN
bjp-18180	193	18	,	,	PUNCT
bjp-18180	193	19	kostrewa	kostrewa	PROPN
bjp-18180	193	20	d	d	PROPN
bjp-18180	193	21	,	,	PUNCT
bjp-18180	193	22	kuehne	kuehne	PROPN
bjp-18180	193	23	h	h	PROPN
bjp-18180	193	24	,	,	PUNCT
bjp-18180	193	25	luebbers	luebbers	PROPN
bjp-18180	193	26	t	t	PROPN
bjp-18180	193	27	,	,	PUNCT
bjp-18180	193	28	meunierkeller	meunierkeller	NOUN
bjp-18180	193	29	n	n	NOUN
bjp-18180	193	30	,	,	PUNCT
bjp-18180	193	31	mueller	mueller	PROPN
bjp-18180	193	32	f.	f.	PROPN
bjp-18180	193	33	novel	novel	PROPN
bjp-18180	193	34	inhibitors	inhibitor	NOUN
bjp-18180	193	35	of	of	ADP
bjp-18180	193	36	dna	dna	PROPN
bjp-18180	193	37	gyrase	gyrase	NOUN
bjp-18180	193	38	:	:	PUNCT
bjp-18180	193	39	3d	3d	NUM
bjp-18180	193	40	structure	structure	NOUN
bjp-18180	193	41	based	base	VERB
bjp-18180	193	42	biased	biased	ADJ
bjp-18180	193	43	needle	needle	NOUN
bjp-18180	193	44	screening	screening	NOUN
bjp-18180	193	45	,	,	PUNCT
bjp-18180	193	46	hit	hit	VERB
bjp-18180	193	47	validation	validation	NOUN
bjp-18180	193	48	by	by	ADP
bjp-18180	193	49	biophysical	biophysical	ADJ
bjp-18180	193	50	methods	method	NOUN
bjp-18180	193	51	,	,	PUNCT
bjp-18180	193	52	and	and	CCONJ
bjp-18180	193	53	3d	3d	NUM
bjp-18180	193	54	guided	guide	VERB
bjp-18180	193	55	optimization	optimization	NOUN
bjp-18180	193	56	.	.	PUNCT
bjp-18180	194	1	a	a	DET
bjp-18180	194	2	promising	promising	ADJ
bjp-18180	194	3	alternative	alternative	NOUN
bjp-18180	194	4	to	to	ADP
bjp-18180	194	5	random	random	ADJ
bjp-18180	194	6	screening	screening	NOUN
bjp-18180	194	7	.	.	PUNCT
bjp-18180	195	1	j	j	PROPN
bjp-18180	195	2	med	med	PROPN
bjp-18180	195	3	chem	chem	NOUN
bjp-18180	195	4	.	.	PUNCT
bjp-18180	196	1	2000	2000	NUM
bjp-18180	196	2	;	;	PUNCT
bjp-18180	196	3	43	43	NUM
bjp-18180	196	4	:	:	PUNCT
bjp-18180	196	5	2664	2664	NUM
bjp-18180	196	6	-	-	SYM
bjp-18180	196	7	74	74	NUM
bjp-18180	196	8	.	.	PUNCT
bjp-18180	197	1	champoux	champoux	PROPN
bjp-18180	197	2	jj	jj	PROPN
bjp-18180	197	3	.	.	PROPN
bjp-18180	197	4	dna	dna	PROPN
bjp-18180	197	5	topoisomerases	topoisomerase	NOUN
bjp-18180	197	6	:	:	PUNCT
bjp-18180	197	7	structure	structure	NOUN
bjp-18180	197	8	,	,	PUNCT
bjp-18180	197	9	function	function	NOUN
bjp-18180	197	10	,	,	PUNCT
bjp-18180	197	11	and	and	CCONJ
bjp-18180	197	12	mechanism	mechanism	NOUN
bjp-18180	197	13	.	.	PUNCT
bjp-18180	198	1	annu	annu	PROPN
bjp-18180	198	2	rev	rev	VERB
bjp-18180	198	3	biochem	biochem	PROPN
bjp-18180	198	4	.	.	PUNCT
bjp-18180	199	1	2001	2001	NUM
bjp-18180	199	2	;	;	PUNCT
bjp-18180	199	3	70	70	NUM
bjp-18180	199	4	:	:	PUNCT
bjp-18180	199	5	369	369	NUM
bjp-18180	199	6	-	-	SYM
bjp-18180	199	7	413	413	NUM
bjp-18180	199	8	.	.	PUNCT
bjp-18180	200	1	dong	dong	PROPN
bjp-18180	200	2	kc	kc	PROPN
bjp-18180	200	3	,	,	PUNCT
bjp-18180	200	4	berger	berger	PROPN
bjp-18180	200	5	jm	jm	PROPN
bjp-18180	200	6	.	.	PROPN
bjp-18180	200	7	structural	structural	ADJ
bjp-18180	200	8	basis	basis	NOUN
bjp-18180	200	9	for	for	ADP
bjp-18180	200	10	gate	gate	NOUN
bjp-18180	200	11	-	-	PUNCT
bjp-18180	200	12	dna	dna	PROPN
bjp-18180	200	13	recognition	recognition	NOUN
bjp-18180	200	14	and	and	CCONJ
bjp-18180	200	15	bending	bend	VERB
bjp-18180	200	16	by	by	ADP
bjp-18180	200	17	type	type	NOUN
bjp-18180	200	18	iia	iia	NOUN
bjp-18180	200	19	topoisomerases	topoisomerase	NOUN
bjp-18180	200	20	.	.	PUNCT
bjp-18180	201	1	nature	nature	NOUN
bjp-18180	201	2	2007	2007	NUM
bjp-18180	201	3	;	;	PUNCT
bjp-18180	201	4	450	450	NUM
bjp-18180	201	5	:	:	SYM
bjp-18180	201	6	1201	1201	NUM
bjp-18180	201	7	-	-	SYM
bjp-18180	201	8	05	05	PROPN
bjp-18180	201	9	.	.	PUNCT
bjp-18180	202	1	fortune	fortune	PROPN
bjp-18180	202	2	jm	jm	PROPN
bjp-18180	202	3	,	,	PUNCT
bjp-18180	202	4	prog	prog	NOUN
bjp-18180	202	5	on	on	ADP
bjp-18180	202	6	.	.	PUNCT
bjp-18180	203	1	topoisomerase	topoisomerase	PROPN
bjp-18180	203	2	ii	ii	PROPN
bjp-18180	203	3	as	as	ADP
bjp-18180	203	4	a	a	DET
bjp-18180	203	5	target	target	NOUN
bjp-18180	203	6	for	for	ADP
bjp-18180	203	7	anticancer	anticancer	NOUN
bjp-18180	203	8	drugs	drug	NOUN
bjp-18180	203	9	:	:	PUNCT
bjp-18180	203	10	when	when	SCONJ
bjp-18180	203	11	enzymes	enzyme	NOUN
bjp-18180	203	12	stop	stop	VERB
bjp-18180	203	13	being	be	AUX
bjp-18180	203	14	nice	nice	ADJ
bjp-18180	203	15	.	.	PUNCT
bjp-18180	204	1	prog	prog	ADJ
bjp-18180	204	2	nucleic	nucleic	ADJ
bjp-18180	204	3	acid	acid	NOUN
bjp-18180	204	4	res	re	NOUN
bjp-18180	204	5	mol	mol	ADP
bjp-18180	204	6	biol	biol	PROPN
bjp-18180	204	7	.	.	PUNCT
bjp-18180	205	1	2000	2000	NUM
bjp-18180	205	2	;	;	PUNCT
bjp-18180	205	3	64	64	NUM
bjp-18180	205	4	:	:	PUNCT
bjp-18180	205	5	221	221	NUM
bjp-18180	205	6	-	-	SYM
bjp-18180	205	7	53	53	NUM
bjp-18180	205	8	.	.	PUNCT
bjp-18180	206	1	heck	heck	INTJ
bjp-18180	206	2	mm	mm	INTJ
bjp-18180	206	3	,	,	PUNCT
bjp-18180	206	4	earnshaw	earnshaw	PROPN
bjp-18180	206	5	wc	wc	PROPN
bjp-18180	206	6	.	.	PUNCT
bjp-18180	207	1	topoisomerase	topoisomerase	PROPN
bjp-18180	207	2	ii	ii	PROPN
bjp-18180	207	3	:	:	PUNCT
bjp-18180	207	4	a	a	DET
bjp-18180	207	5	specific	specific	ADJ
bjp-18180	207	6	marker	marker	NOUN
bjp-18180	207	7	for	for	ADP
bjp-18180	207	8	cell	cell	NOUN
bjp-18180	207	9	proliferation	proliferation	NOUN
bjp-18180	207	10	.	.	PUNCT
bjp-18180	208	1	j	j	PROPN
bjp-18180	208	2	cell	cell	NOUN
bjp-18180	208	3	biol	biol	PROPN
bjp-18180	208	4	.	.	PUNCT
bjp-18180	209	1	1986	1986	NUM
bjp-18180	209	2	;	;	PUNCT
bjp-18180	209	3	103	103	NUM
bjp-18180	209	4	:	:	SYM
bjp-18180	209	5	2569	2569	NUM
bjp-18180	209	6	-	-	SYM
bjp-18180	209	7	81	81	NUM
bjp-18180	209	8	.	.	PUNCT
bjp-18180	209	9	hu	hu	PROPN
bjp-18180	209	10	cx	cx	PROPN
bjp-18180	209	11	,	,	PUNCT
bjp-18180	209	12	zuo	zuo	PROPN
bjp-18180	209	13	zl	zl	PROPN
bjp-18180	209	14	,	,	PUNCT
bjp-18180	209	15	xiong	xiong	PROPN
bjp-18180	209	16	b	b	PROPN
bjp-18180	209	17	,	,	PUNCT
bjp-18180	209	18	ma	ma	PROPN
bjp-18180	209	19	jg	jg	PROPN
bjp-18180	209	20	,	,	PUNCT
bjp-18180	209	21	geng	geng	PROPN
bjp-18180	209	22	my	my	PRON
bjp-18180	209	23	,	,	PUNCT
bjp-18180	209	24	lin	lin	PROPN
bjp-18180	209	25	lp	lp	PROPN
bjp-18180	209	26	,	,	PUNCT
bjp-18180	209	27	jiang	jiang	PROPN
bjp-18180	209	28	hl	hl	PROPN
bjp-18180	209	29	,	,	PUNCT
bjp-18180	209	30	ding	ding	PROPN
bjp-18180	209	31	j.	j.	PROPN
bjp-18180	209	32	salvicine	salvicine	PROPN
bjp-18180	209	33	functions	function	NOUN
bjp-18180	209	34	as	as	ADP
bjp-18180	209	35	novel	novel	ADJ
bjp-18180	209	36	topoisomerase	topoisomerase	NOUN
bjp-18180	209	37	ii	ii	NOUN
bjp-18180	209	38	poison	poison	NOUN
bjp-18180	209	39	by	by	ADP
bjp-18180	209	40	binding	bind	VERB
bjp-18180	209	41	to	to	ADP
bjp-18180	209	42	atp	atp	NOUN
bjp-18180	209	43	pocket	pocket	NOUN
bjp-18180	209	44	.	.	PUNCT
bjp-18180	210	1	mol	mol	ADP
bjp-18180	210	2	pharmacol	pharmacol	PROPN
bjp-18180	210	3	.	.	PUNCT
bjp-18180	211	1	2006	2006	NUM
bjp-18180	211	2	;	;	PUNCT
bjp-18180	211	3	70	70	NUM
bjp-18180	211	4	:	:	PUNCT
bjp-18180	211	5	1593	1593	NUM
bjp-18180	211	6	-	-	SYM
bjp-18180	211	7	601	601	NUM
bjp-18180	211	8	.	.	PUNCT
bjp-18180	212	1	jun	jun	PROPN
bjp-18180	212	2	ky	ky	PROPN
bjp-18180	212	3	,	,	PUNCT
bjp-18180	212	4	lee	lee	PROPN
bjp-18180	212	5	ey	ey	PROPN
bjp-18180	212	6	,	,	PUNCT
bjp-18180	212	7	jung	jung	PROPN
bjp-18180	212	8	mj	mj	PROPN
bjp-18180	212	9	,	,	PUNCT
bjp-18180	212	10	lee	lee	PROPN
bjp-18180	212	11	oh	oh	INTJ
bjp-18180	212	12	,	,	PUNCT
bjp-18180	212	13	lee	lee	PROPN
bjp-18180	212	14	es	es	PROPN
bjp-18180	212	15	,	,	PUNCT
bjp-18180	212	16	park	park	NOUN
bjp-18180	212	17	choo	choo	PROPN
bjp-18180	212	18	hy	hy	PROPN
bjp-18180	212	19	,	,	PUNCT
bjp-18180	212	20	na	na	ADP
bjp-18180	212	21	y	y	PROPN
bjp-18180	212	22	,	,	PUNCT
bjp-18180	212	23	kwon	kwon	PROPN
bjp-18180	212	24	y.	y.	PROPN
bjp-18180	212	25	synthesis	synthesis	PROPN
bjp-18180	212	26	,	,	PUNCT
bjp-18180	212	27	biological	biological	ADJ
bjp-18180	212	28	evaluation	evaluation	NOUN
bjp-18180	212	29	,	,	PUNCT
bjp-18180	212	30	and	and	CCONJ
bjp-18180	212	31	molecular	molecular	ADJ
bjp-18180	212	32	docking	docking	NOUN
bjp-18180	212	33	study	study	NOUN
bjp-18180	212	34	of	of	ADP
bjp-18180	212	35	3-(30	3-(30	PROPN
bjp-18180	212	36	-	-	PUNCT
bjp-18180	212	37	heteroatom	heteroatom	NOUN
bjp-18180	212	38	substituted-20	substituted-20	PROPN
bjp-18180	212	39	-	-	PUNCT
bjp-18180	212	40	hydroxy10	hydroxy10	ADJ
bjp-18180	212	41	-	-	PUNCT
bjp-18180	212	42	propyloxy	propyloxy	NOUN
bjp-18180	212	43	)	)	PUNCT
bjp-18180	212	44	xanthone	xanthone	PROPN
bjp-18180	212	45	analogues	analogue	NOUN
bjp-18180	212	46	as	as	ADP
bjp-18180	212	47	novel	novel	NOUN
bjp-18180	212	48	topoisomerase	topoisomerase	NOUN
bjp-18180	212	49	iia	iia	PROPN
bjp-18180	212	50	catalytic	catalytic	ADJ
bjp-18180	212	51	inhibitor	inhibitor	NOUN
bjp-18180	212	52	.	.	PUNCT
bjp-18180	213	1	eur	eur	PROPN
bjp-18180	213	2	j	j	PROPN
bjp-18180	213	3	med	med	PROPN
bjp-18180	213	4	chem	chem	NOUN
bjp-18180	213	5	.	.	PUNCT
bjp-18180	214	1	2011	2011	NUM
bjp-18180	214	2	;	;	PUNCT
bjp-18180	214	3	46	46	NUM
bjp-18180	214	4	:	:	SYM
bjp-18180	214	5	1964	1964	NUM
bjp-18180	214	6	-	-	SYM
bjp-18180	214	7	71	71	NUM
bjp-18180	214	8	.	.	PUNCT
bjp-18180	215	1	larsen	larsen	PROPN
bjp-18180	215	2	ak	ak	PROPN
bjp-18180	215	3	,	,	PUNCT
bjp-18180	215	4	escargueil	escargueil	PROPN
bjp-18180	215	5	ae	ae	PROPN
bjp-18180	215	6	,	,	PUNCT
bjp-18180	215	7	skladanowski	skladanowski	PROPN
bjp-18180	215	8	a.	a.	PROPN
bjp-18180	215	9	catalytic	catalytic	PROPN
bjp-18180	215	10	topoisomerase	topoisomerase	PROPN
bjp-18180	215	11	ii	ii	PROPN
bjp-18180	215	12	inhibitors	inhibitor	NOUN
bjp-18180	215	13	in	in	ADP
bjp-18180	215	14	cancer	cancer	NOUN
bjp-18180	215	15	therapy	therapy	NOUN
bjp-18180	215	16	.	.	PUNCT
bjp-18180	216	1	pharmacol	pharmacol	VERB
bjp-18180	216	2	ther	ther	ADV
bjp-18180	216	3	.	.	PUNCT
bjp-18180	217	1	2003	2003	NUM
bjp-18180	217	2	;	;	PUNCT
bjp-18180	217	3	99	99	NUM
bjp-18180	217	4	:	:	SYM
bjp-18180	217	5	167	167	NUM
bjp-18180	217	6	-	-	SYM
bjp-18180	217	7	81	81	NUM
bjp-18180	217	8	.	.	PUNCT
bjp-18180	218	1	liu	liu	PROPN
bjp-18180	218	2	lf	lf	PROPN
bjp-18180	218	3	.	.	PROPN
bjp-18180	218	4	dna	dna	PROPN
bjp-18180	218	5	topoisomerase	topoisomerase	NOUN
bjp-18180	218	6	poisons	poison	NOUN
bjp-18180	218	7	as	as	ADP
bjp-18180	218	8	antitumor	antitumor	PROPN
bjp-18180	218	9	drugs	drug	NOUN
bjp-18180	218	10	.	.	PUNCT
bjp-18180	219	1	ann	ann	PROPN
bjp-18180	219	2	rev	rev	PROPN
bjp-18180	219	3	biochem	biochem	PROPN
bjp-18180	219	4	.	.	PUNCT
bjp-18180	219	5	1989	1989	NUM
bjp-18180	219	6	;	;	PUNCT
bjp-18180	219	7	58	58	NUM
bjp-18180	219	8	:	:	PUNCT
bjp-18180	219	9	351	351	NUM
bjp-18180	219	10	-	-	SYM
bjp-18180	219	11	75	75	NUM
bjp-18180	219	12	.	.	PUNCT
bjp-18180	219	13	nitiss	nitiss	PROPN
bjp-18180	219	14	jl	jl	PROPN
bjp-18180	219	15	.	.	PUNCT
bjp-18180	220	1	targeting	target	VERB
bjp-18180	220	2	dna	dna	PROPN
bjp-18180	220	3	topoisomerase	topoisomerase	PROPN
bjp-18180	220	4	ii	ii	PROPN
bjp-18180	220	5	in	in	ADP
bjp-18180	220	6	cancer	cancer	NOUN
bjp-18180	220	7	chemotherapy	chemotherapy	NOUN
bjp-18180	220	8	.	.	PUNCT
bjp-18180	221	1	nat	nat	PROPN
bjp-18180	221	2	rev	rev	PROPN
bjp-18180	221	3	cancer	cancer	NOUN
bjp-18180	221	4	.	.	PUNCT
bjp-18180	222	1	2009	2009	NUM
bjp-18180	222	2	;	;	PUNCT
bjp-18180	222	3	9	9	NUM
bjp-18180	222	4	:	:	SYM
bjp-18180	222	5	338	338	NUM
bjp-18180	222	6	-	-	SYM
bjp-18180	222	7	50	50	NUM
bjp-18180	222	8	.	.	PUNCT
bjp-18180	223	1	patil	patil	PROPN
bjp-18180	223	2	td	td	PROPN
bjp-18180	223	3	,	,	PUNCT
bjp-18180	223	4	thakare	thakare	NOUN
bjp-18180	223	5	sv	sv	PROPN
bjp-18180	223	6	.	.	PUNCT
bjp-18180	224	1	in	in	ADP
bjp-18180	224	2	silico	silico	NOUN
bjp-18180	224	3	evaluation	evaluation	NOUN
bjp-18180	224	4	of	of	ADP
bjp-18180	224	5	selected	select	VERB
bjp-18180	224	6	triterpene	triterpene	ADJ
bjp-18180	224	7	glycosides	glycoside	NOUN
bjp-18180	224	8	as	as	ADP
bjp-18180	224	9	a	a	DET
bjp-18180	224	10	human	human	ADJ
bjp-18180	224	11	dna	dna	NOUN
bjp-18180	224	12	topoisomerase	topoisomerase	PROPN
bjp-18180	224	13	ii	ii	PROPN
bjp-18180	224	14	alpha	alpha	NOUN
bjp-18180	224	15	(	(	PUNCT
bjp-18180	224	16	)	)	PUNCT
bjp-18180	224	17	inhibitor	inhibitor	NOUN
bjp-18180	224	18	.	.	PUNCT
bjp-18180	225	1	int	int	PROPN
bjp-18180	225	2	j	j	PROPN
bjp-18180	225	3	pharm	pharm	PROPN
bjp-18180	225	4	pharm	pharm	PROPN
bjp-18180	225	5	sci	sci	PROPN
bjp-18180	225	6	.	.	PROPN
bjp-18180	225	7	2012	2012	NUM
bjp-18180	225	8	;	;	PUNCT
bjp-18180	225	9	4	4	NUM
bjp-18180	225	10	:	:	PUNCT
bjp-18180	225	11	201	201	NUM
bjp-18180	225	12	-	-	SYM
bjp-18180	225	13	04	04	NUM
bjp-18180	225	14	.	.	PUNCT
bjp-18180	226	1	robinson	robinson	PROPN
bjp-18180	226	2	mj	mj	PROPN
bjp-18180	226	3	,	,	PUNCT
bjp-18180	226	4	osheroff	osheroff	NOUN
bjp-18180	226	5	n.	n.	NOUN
bjp-18180	226	6	effects	effect	NOUN
bjp-18180	226	7	of	of	ADP
bjp-18180	226	8	antineoplastic	antineoplastic	ADJ
bjp-18180	226	9	drugs	drug	NOUN
bjp-18180	226	10	on	on	ADP
bjp-18180	226	11	the	the	DET
bjp-18180	226	12	post	post	ADJ
bjp-18180	226	13	-	-	ADJ
bjp-18180	226	14	strand	strand	ADJ
bjp-18180	226	15	-	-	PUNCT
bjp-18180	226	16	passage	passage	NOUN
bjp-18180	226	17	dna	dna	PROPN
bjp-18180	226	18	cleavage	cleavage	NOUN
bjp-18180	226	19	/	/	SYM
bjp-18180	226	20	religation	religation	NOUN
bjp-18180	226	21	equilibrium	equilibrium	NOUN
bjp-18180	226	22	of	of	ADP
bjp-18180	226	23	topoisomerase	topoisomerase	PROPN
bjp-18180	226	24	ii	ii	PROPN
bjp-18180	226	25	.	.	PUNCT
bjp-18180	227	1	biochemistry	biochemistry	PROPN
bjp-18180	227	2	1991	1991	NUM
bjp-18180	227	3	;	;	PUNCT
bjp-18180	227	4	30	30	NUM
bjp-18180	227	5	:	:	SYM
bjp-18180	227	6	1807	1807	NUM
bjp-18180	227	7	-	-	SYM
bjp-18180	227	8	13	13	NUM
bjp-18180	227	9	.	.	PUNCT
bjp-18180	228	1	shen	shen	PROPN
bjp-18180	228	2	r	r	PROPN
bjp-18180	228	3	,	,	PUNCT
bjp-18180	228	4	wang	wang	PROPN
bjp-18180	228	5	p	p	PROPN
bjp-18180	228	6	,	,	PUNCT
bjp-18180	228	7	tang	tang	PROPN
bjp-18180	228	8	n.	n.	ADJ
bjp-18180	228	9	cytotoxic	cytotoxic	ADJ
bjp-18180	228	10	activity	activity	NOUN
bjp-18180	228	11	and	and	CCONJ
bjp-18180	228	12	dna	dna	NOUN
bjp-18180	228	13	-	-	PUNCT
bjp-18180	228	14	binding	bind	VERB
bjp-18180	228	15	properties	property	NOUN
bjp-18180	228	16	of	of	ADP
bjp-18180	228	17	xanthone	xanthone	PROPN
bjp-18180	228	18	derivatives	derivative	NOUN
bjp-18180	228	19	.	.	PUNCT
bjp-18180	229	1	j	j	PROPN
bjp-18180	229	2	fluoresc	fluoresc	PROPN
bjp-18180	229	3	.	.	PUNCT
bjp-18180	230	1	2010	2010	NUM
bjp-18180	230	2	;	;	PUNCT
bjp-18180	230	3	20	20	NUM
bjp-18180	230	4	:	:	SYM
bjp-18180	230	5	1287	1287	NUM
bjp-18180	230	6	-	-	SYM
bjp-18180	230	7	97	97	NUM
bjp-18180	230	8	.	.	PUNCT
bjp-18180	231	1	su	su	PROPN
bjp-18180	231	2	qg	qg	PROPN
bjp-18180	231	3	,	,	PUNCT
bjp-18180	231	4	liu	liu	PROPN
bjp-18180	231	5	y	y	PROPN
bjp-18180	231	6	,	,	PUNCT
bjp-18180	231	7	cai	cai	PROPN
bjp-18180	231	8	yc	yc	PROPN
bjp-18180	231	9	,	,	PUNCT
bjp-18180	231	10	sun	sun	NOUN
bjp-18180	231	11	yl	yl	NOUN
bjp-18180	231	12	,	,	PUNCT
bjp-18180	231	13	wang	wang	PROPN
bjp-18180	231	14	b	b	PROPN
bjp-18180	231	15	,	,	PUNCT
bjp-18180	231	16	xian	xian	PROPN
bjp-18180	231	17	lj	lj	PROPN
bjp-18180	231	18	.	.	PUNCT
bjp-18180	232	1	anti	anti	ADJ
bjp-18180	232	2	-	-	ADJ
bjp-18180	232	3	tumour	tumour	ADJ
bjp-18180	232	4	effects	effect	NOUN
bjp-18180	232	5	of	of	ADP
bjp-18180	232	6	xanthone	xanthone	PROPN
bjp-18180	232	7	derivatives	derivative	NOUN
bjp-18180	232	8	and	and	CCONJ
bjp-18180	232	9	the	the	DET
bjp-18180	232	10	possible	possible	ADJ
bjp-18180	232	11	mechanisms	mechanism	NOUN
bjp-18180	232	12	of	of	ADP
bjp-18180	232	13	action	action	NOUN
bjp-18180	232	14	.	.	PUNCT
bjp-18180	233	1	invest	invest	VERB
bjp-18180	233	2	new	new	ADJ
bjp-18180	233	3	drugs	drug	NOUN
bjp-18180	233	4	.	.	PUNCT
bjp-18180	234	1	2011	2011	NUM
bjp-18180	234	2	;	;	PUNCT
bjp-18180	234	3	29	29	NUM
bjp-18180	234	4	:	:	SYM
bjp-18180	234	5	1230	1230	NUM
bjp-18180	234	6	-	-	SYM
bjp-18180	234	7	40	40	NUM
bjp-18180	234	8	.	.	PUNCT
bjp-18180	235	1	vilain	vilain	PROPN
bjp-18180	235	2	n	n	PROPN
bjp-18180	235	3	,	,	PUNCT
bjp-18180	235	4	tsai	tsai	PROPN
bjp-18180	235	5	-	-	PUNCT
bjp-18180	235	6	pflugfelder	pflugfelder	PROPN
bjp-18180	235	7	m	m	PROPN
bjp-18180	235	8	,	,	PUNCT
bjp-18180	235	9	benoit	benoit	PROPN
bjp-18180	235	10	a	a	NOUN
bjp-18180	235	11	,	,	PUNCT
bjp-18180	235	12	gasser	gasser	PROPN
bjp-18180	235	13	sm	sm	PROPN
bjp-18180	235	14	,	,	PUNCT
bjp-18180	235	15	leroy	leroy	PROPN
bjp-18180	235	16	d.	d.	PROPN
bjp-18180	235	17	modulation	modulation	NOUN
bjp-18180	235	18	of	of	ADP
bjp-18180	235	19	drug	drug	NOUN
bjp-18180	235	20	sensitivity	sensitivity	NOUN
bjp-18180	235	21	in	in	ADP
bjp-18180	235	22	yeast	yeast	NOUN
bjp-18180	235	23	cells	cell	NOUN
bjp-18180	235	24	by	by	ADP
bjp-18180	235	25	the	the	DET
bjp-18180	235	26	tpbinding	tpbinding	NOUN
bjp-18180	235	27	domain	domain	NOUN
bjp-18180	235	28	of	of	ADP
bjp-18180	235	29	human	human	ADJ
bjp-18180	235	30	dna	dna	PROPN
bjp-18180	235	31	topoisomerase	topoisomerase	VERB
bjp-18180	235	32	iia	iia	NOUN
bjp-18180	235	33	.	.	PUNCT
bjp-18180	236	1	nucleic	nucleic	ADJ
bjp-18180	236	2	acids	acid	NOUN
bjp-18180	236	3	res	re	NOUN
bjp-18180	236	4	.	.	PUNCT
bjp-18180	236	5	2003	2003	NUM
bjp-18180	236	6	;	;	PUNCT
bjp-18180	236	7	31	31	NUM
bjp-18180	236	8	:	:	SYM
bjp-18180	236	9	5714	5714	NUM
bjp-18180	236	10	-	-	SYM
bjp-18180	236	11	22	22	NUM
bjp-18180	236	12	.	.	PUNCT
bjp-18180	237	1	watt	watt	PROPN
bjp-18180	237	2	pm	pm	PROPN
bjp-18180	237	3	,	,	PUNCT
bjp-18180	237	4	hickson	hickson	PROPN
bjp-18180	237	5	i	i	PROPN
bjp-18180	237	6	d.	d.	PROPN
bjp-18180	237	7	structure	structure	NOUN
bjp-18180	237	8	and	and	CCONJ
bjp-18180	237	9	function	function	NOUN
bjp-18180	237	10	of	of	ADP
bjp-18180	237	11	type	type	NOUN
bjp-18180	237	12	ii	ii	PROPN
bjp-18180	237	13	dna	dna	PROPN
bjp-18180	237	14	topoisomerases	topoisomerase	NOUN
bjp-18180	237	15	.	.	PUNCT
bjp-18180	238	1	biochem	biochem	PROPN
bjp-18180	238	2	j.	j.	PROPN
bjp-18180	238	3	1994	1994	NUM
bjp-18180	238	4	;	;	PUNCT
bjp-18180	238	5	303	303	NUM
bjp-18180	238	6	:	:	PUNCT
bjp-18180	238	7	681	681	NUM
bjp-18180	238	8	-	-	SYM
bjp-18180	238	9	95	95	NUM
bjp-18180	238	10	.	.	PUNCT
bjp-18180	239	1	wilstermann	wilstermann	PROPN
bjp-18180	239	2	am	be	AUX
bjp-18180	239	3	,	,	PUNCT
bjp-18180	239	4	osheroff	osheroff	ADP
bjp-18180	239	5	n.	n.	NOUN
bjp-18180	239	6	stabilization	stabilization	NOUN
bjp-18180	239	7	of	of	ADP
bjp-18180	239	8	eukaryotic	eukaryotic	ADJ
bjp-18180	239	9	topoisomerase	topoisomerase	ADJ
bjp-18180	239	10	ii	ii	ADJ
bjp-18180	239	11	-	-	ADJ
bjp-18180	239	12	dna	dna	PROPN
bjp-18180	239	13	cleavage	cleavage	NOUN
bjp-18180	239	14	complexes	complex	NOUN
bjp-18180	239	15	.	.	PUNCT
bjp-18180	240	1	curr	curr	PROPN
bjp-18180	240	2	top	top	ADJ
bjp-18180	240	3	med	med	ADJ
bjp-18180	240	4	chem	chem	NOUN
bjp-18180	240	5	.	.	PUNCT
bjp-18180	241	1	2003	2003	NUM
bjp-18180	241	2	;	;	PUNCT
bjp-18180	242	1	3	3	NUM
bjp-18180	242	2	:	:	SYM
bjp-18180	242	3	321	321	NUM
bjp-18180	242	4	-	-	SYM
bjp-18180	242	5	38	38	NUM
bjp-18180	242	6	.	.	PUNCT
bjp-18180	242	7	woessner	woessner	PROPN
bjp-18180	242	8	rd	rd	PROPN
bjp-18180	242	9	,	,	PUNCT
bjp-18180	242	10	mattern	mattern	PROPN
bjp-18180	242	11	mr	mr	PROPN
bjp-18180	242	12	,	,	PUNCT
bjp-18180	242	13	mirabelli	mirabelli	NOUN
bjp-18180	242	14	ck	ck	PROPN
bjp-18180	242	15	,	,	PUNCT
bjp-18180	242	16	johnson	johnson	PROPN
bjp-18180	242	17	rk	rk	PROPN
bjp-18180	242	18	,	,	PUNCT
bjp-18180	242	19	drake	drake	PROPN
bjp-18180	242	20	fh	fh	PROPN
bjp-18180	242	21	.	.	PUNCT
bjp-18180	242	22	proliferationand	proliferationand	PROPN
bjp-18180	242	23	cell	cell	NOUN
bjp-18180	242	24	cycle	cycle	NOUN
bjp-18180	242	25	-	-	PUNCT
bjp-18180	242	26	dependent	dependent	ADJ
bjp-18180	242	27	differences	difference	NOUN
bjp-18180	242	28	in	in	ADP
bjp-18180	242	29	expression	expression	NOUN
bjp-18180	242	30	of	of	ADP
bjp-18180	242	31	the	the	DET
bjp-18180	242	32	170	170	NUM
bjp-18180	242	33	kilodalton	kilodalton	NOUN
bjp-18180	242	34	and	and	CCONJ
bjp-18180	242	35	180	180	NUM
bjp-18180	242	36	kilodalton	kilodalton	NOUN
bjp-18180	242	37	forms	form	NOUN
bjp-18180	242	38	of	of	ADP
bjp-18180	242	39	topoisomerase	topoisomerase	NOUN
bjp-18180	242	40	ii	ii	PROPN
bjp-18180	242	41	in	in	ADP
bjp-18180	242	42	nih-3t3	nih-3t3	PROPN
bjp-18180	242	43	cells	cell	NOUN
bjp-18180	242	44	.	.	PUNCT
bjp-18180	243	1	cell	cell	NOUN
bjp-18180	243	2	growth	growth	NOUN
bjp-18180	243	3	differ	differ	VERB
bjp-18180	243	4	.	.	PUNCT
bjp-18180	243	5	1991	1991	NUM
bjp-18180	243	6	;	;	PUNCT
bjp-18180	244	1	2	2	NUM
bjp-18180	244	2	:	:	PUNCT
bjp-18180	244	3	209	209	NUM
bjp-18180	244	4	-	-	SYM
bjp-18180	244	5	14	14	NUM
bjp-18180	244	6	.	.	PUNCT
bjp-18180	244	7	bjp	bjp	NOUN
bjp-18180	244	8	:	:	PUNCT
bjp-18180	244	9	acknowledgement	acknowledgement	NOUN
bjp-18180	244	10	:	:	PUNCT
bjp-18180	244	11	references	reference	NOUN
bjp-18180	244	12	:	:	PUNCT
bjp-18180	244	13	author	author	NOUN
bjp-18180	244	14	info	info	NOUN
bjp-18180	244	15	pratap	pratap	PROPN
bjp-18180	244	16	parida	parida	PROPN
bjp-18180	244	17	principal	principal	PROPN
bjp-18180	244	18	contact	contact	NOUN
bjp-18180	244	19	email	email	NOUN
bjp-18180	244	20	pratapparida2007yahoocom	pratapparida2007yahoocom	PROPN
bjp-18180	244	21	gmailcom	gmailcom	PROPN
bjp-18180	244	22	:	:	PUNCT
bjp-18180	244	23	dateprinted	dateprinte	VERB
bjp-18180	244	24	:	:	PUNCT
bjp-18180	244	25	this	this	DET
bjp-18180	244	26	article	article	NOUN
bjp-18180	244	27	was	be	AUX
bjp-18180	244	28	downloaded	download	VERB
bjp-18180	244	29	by	by	ADP
bjp-18180	244	30	you	you	PRON
bjp-18180	244	31	on	on	ADP
bjp-18180	244	32	:	:	PUNCT
bjp-18180	244	33	jul	jul	PROPN
bjp-18180	244	34	09	09	NUM
bjp-18180	244	35	,	,	PUNCT
bjp-18180	244	36	2018	2018	NUM