id	sid	tid	token	lemma	pos
bjp-19065	1	1	bangladesh	bangladesh	PROPN
bjp-19065	1	2	journal	journal	PROPN
bjp-19065	1	3	of	of	ADP
bjp-19065	1	4	pharmacology	pharmacology	NOUN
bjp-19065	1	5	research	research	NOUN
bjp-19065	1	6	article	article	NOUN
bjp-19065	1	7	in	in	ADP
bjp-19065	1	8	silico	silico	NOUN
bjp-19065	1	9	targeting	target	VERB
bjp-19065	1	10	of	of	ADP
bjp-19065	1	11	interleukin-6	interleukin-6	NUM
bjp-19065	1	12	by	by	ADP
bjp-19065	1	13	natural	natural	ADJ
bjp-19065	1	14	compounds	compound	NOUN
bjp-19065	1	15	bjp	bjp	NOUN
bjp-19065	1	16	introduction	introduction	NOUN
bjp-19065	1	17	early	early	ADJ
bjp-19065	1	18	mortality	mortality	NOUN
bjp-19065	1	19	,	,	PUNCT
bjp-19065	1	20	severe	severe	ADJ
bjp-19065	1	21	disability	disability	NOUN
bjp-19065	1	22	and	and	CCONJ
bjp-19065	1	23	structural	structural	ADJ
bjp-19065	1	24	damages	damage	NOUN
bjp-19065	1	25	are	be	AUX
bjp-19065	1	26	the	the	DET
bjp-19065	1	27	outcome	outcome	NOUN
bjp-19065	1	28	of	of	ADP
bjp-19065	1	29	a	a	DET
bjp-19065	1	30	chronic	chronic	ADJ
bjp-19065	1	31	inflammatory	inflammatory	ADJ
bjp-19065	1	32	autoimmune	autoimmune	ADJ
bjp-19065	1	33	disorder	disorder	NOUN
bjp-19065	1	34	,	,	PUNCT
bjp-19065	1	35	rheumatoid	rheumatoid	NOUN
bjp-19065	1	36	arthritis	arthritis	NOUN
bjp-19065	1	37	(	(	PUNCT
bjp-19065	1	38	klareskog	klareskog	PROPN
bjp-19065	1	39	et	et	PROPN
bjp-19065	1	40	al	al	PROPN
bjp-19065	1	41	.	.	PROPN
bjp-19065	1	42	,	,	PUNCT
bjp-19065	1	43	2009	2009	NUM
bjp-19065	1	44	;	;	PUNCT
bjp-19065	1	45	scott	scott	PROPN
bjp-19065	1	46	et	et	PROPN
bjp-19065	1	47	al	al	PROPN
bjp-19065	1	48	.	.	PROPN
bjp-19065	1	49	,	,	PUNCT
bjp-19065	1	50	2010	2010	NUM
bjp-19065	1	51	)	)	PUNCT
bjp-19065	1	52	.	.	PUNCT
bjp-19065	2	1	although	although	SCONJ
bjp-19065	2	2	a	a	DET
bjp-19065	2	3	lot	lot	NOUN
bjp-19065	2	4	of	of	ADP
bjp-19065	2	5	progress	progress	NOUN
bjp-19065	2	6	has	have	AUX
bjp-19065	2	7	been	be	AUX
bjp-19065	2	8	achieved	achieve	VERB
bjp-19065	2	9	in	in	ADP
bjp-19065	2	10	controlling	control	VERB
bjp-19065	2	11	the	the	DET
bjp-19065	2	12	disease	disease	NOUN
bjp-19065	2	13	activity	activity	NOUN
bjp-19065	2	14	by	by	ADP
bjp-19065	2	15	using	use	VERB
bjp-19065	2	16	drugs	drug	NOUN
bjp-19065	2	17	known	know	VERB
bjp-19065	2	18	as	as	ADP
bjp-19065	2	19	disease	disease	NOUN
bjp-19065	2	20	modifying	modify	VERB
bjp-19065	2	21	anti	anti	ADJ
bjp-19065	2	22	-	-	ADJ
bjp-19065	2	23	rheumatic	rheumatic	ADJ
bjp-19065	2	24	drugs	drug	NOUN
bjp-19065	2	25	(	(	PUNCT
bjp-19065	2	26	dmards	dmard	NOUN
bjp-19065	2	27	)	)	PUNCT
bjp-19065	2	28	,	,	PUNCT
bjp-19065	2	29	but	but	CCONJ
bjp-19065	2	30	still	still	ADV
bjp-19065	2	31	challenges	challenge	NOUN
bjp-19065	2	32	are	be	AUX
bjp-19065	2	33	there	there	ADV
bjp-19065	2	34	in	in	ADP
bjp-19065	2	35	early	early	ADJ
bjp-19065	2	36	diagnosis	diagnosis	NOUN
bjp-19065	2	37	and	and	CCONJ
bjp-19065	2	38	treatment	treatment	NOUN
bjp-19065	2	39	(	(	PUNCT
bjp-19065	2	40	mcinnes	mcinne	NOUN
bjp-19065	2	41	at	at	ADP
bjp-19065	2	42	al	al	PROPN
bjp-19065	2	43	.	.	PROPN
bjp-19065	2	44	,	,	PUNCT
bjp-19065	2	45	2011	2011	NUM
bjp-19065	2	46	)	)	PUNCT
bjp-19065	2	47	.	.	PUNCT
bjp-19065	3	1	the	the	DET
bjp-19065	3	2	etiology	etiology	NOUN
bjp-19065	3	3	of	of	ADP
bjp-19065	3	4	rheumatoid	rheumatoid	NOUN
bjp-19065	3	5	arthritis	arthritis	NOUN
bjp-19065	3	6	is	be	AUX
bjp-19065	3	7	a	a	DET
bjp-19065	3	8	mystery	mystery	NOUN
bjp-19065	3	9	till	till	SCONJ
bjp-19065	3	10	date	date	NOUN
bjp-19065	3	11	and	and	CCONJ
bjp-19065	3	12	it	it	PRON
bjp-19065	3	13	is	be	AUX
bjp-19065	3	14	the	the	DET
bjp-19065	3	15	pathogenesis	pathogenesis	NOUN
bjp-19065	3	16	that	that	PRON
bjp-19065	3	17	has	have	AUX
bjp-19065	3	18	been	be	AUX
bjp-19065	3	19	deciphered	decipher	VERB
bjp-19065	3	20	to	to	ADP
bjp-19065	3	21	a	a	DET
bjp-19065	3	22	lot	lot	NOUN
bjp-19065	3	23	of	of	ADP
bjp-19065	3	24	extent	extent	NOUN
bjp-19065	3	25	(	(	PUNCT
bjp-19065	3	26	misato	misato	PROPN
bjp-19065	3	27	et	et	PROPN
bjp-19065	3	28	al	al	PROPN
bjp-19065	3	29	.	.	PROPN
bjp-19065	3	30	,	,	PUNCT
bjp-19065	3	31	2011	2011	NUM
bjp-19065	3	32	)	)	PUNCT
bjp-19065	3	33	.	.	PUNCT
bjp-19065	4	1	il-6	il-6	NOUN
bjp-19065	5	1	a	a	DET
bjp-19065	5	2	highly	highly	ADV
bjp-19065	5	3	up	up	ADV
bjp-19065	5	4	-	-	PUNCT
bjp-19065	5	5	regulated	regulated	ADJ
bjp-19065	5	6	(	(	PUNCT
bjp-19065	5	7	houssiau	houssiau	NOUN
bjp-19065	5	8	et	et	PROPN
bjp-19065	5	9	al	al	PROPN
bjp-19065	5	10	.	.	PROPN
bjp-19065	5	11	,	,	PUNCT
bjp-19065	5	12	1988	1988	NUM
bjp-19065	5	13	;	;	PUNCT
bjp-19065	5	14	madhok	madhok	NOUN
bjp-19065	5	15	et	et	PROPN
bjp-19065	5	16	al	al	PROPN
bjp-19065	5	17	.	.	PROPN
bjp-19065	5	18	,	,	PUNCT
bjp-19065	5	19	1993	1993	NUM
bjp-19065	5	20	)	)	PUNCT
bjp-19065	5	21	cytokine	cytokine	NOUN
bjp-19065	5	22	is	be	AUX
bjp-19065	5	23	a	a	DET
bjp-19065	5	24	key	key	ADJ
bjp-19065	5	25	molecule	molecule	NOUN
bjp-19065	5	26	with	with	ADP
bjp-19065	5	27	a	a	DET
bjp-19065	5	28	pivotal	pivotal	ADJ
bjp-19065	5	29	role	role	NOUN
bjp-19065	5	30	in	in	ADP
bjp-19065	5	31	the	the	DET
bjp-19065	5	32	pathogenesis	pathogenesis	NOUN
bjp-19065	5	33	of	of	ADP
bjp-19065	5	34	rheumatoid	rheumatoid	NOUN
bjp-19065	5	35	arthritis	arthritis	NOUN
bjp-19065	5	36	(	(	PUNCT
bjp-19065	5	37	misato	misato	PROPN
bjp-19065	5	38	et	et	PROPN
bjp-19065	5	39	al	al	PROPN
bjp-19065	5	40	.	.	PROPN
bjp-19065	5	41	,	,	PUNCT
bjp-19065	5	42	2011	2011	NUM
bjp-19065	5	43	)	)	PUNCT
bjp-19065	5	44	.	.	PUNCT
bjp-19065	6	1	its	its	PRON
bjp-19065	6	2	role	role	NOUN
bjp-19065	6	3	in	in	ADP
bjp-19065	6	4	synovitis	synovitis	PROPN
bjp-19065	6	5	(	(	PUNCT
bjp-19065	6	6	maruotti	maruotti	VERB
bjp-19065	6	7	et	et	PROPN
bjp-19065	6	8	al	al	PROPN
bjp-19065	6	9	.	.	PROPN
bjp-19065	6	10	,	,	PUNCT
bjp-19065	6	11	2006	2006	NUM
bjp-19065	6	12	)	)	PUNCT
bjp-19065	6	13	joint	joint	ADJ
bjp-19065	6	14	damage	damage	NOUN
bjp-19065	6	15	(	(	PUNCT
bjp-19065	6	16	gravallese	gravallese	NOUN
bjp-19065	6	17	et	et	PROPN
bjp-19065	6	18	al	al	PROPN
bjp-19065	6	19	.	.	PROPN
bjp-19065	6	20	,	,	PUNCT
bjp-19065	6	21	2000	2000	NUM
bjp-19065	6	22	)	)	PUNCT
bjp-19065	6	23	,	,	PUNCT
bjp-19065	6	24	autoimmunity	autoimmunity	NOUN
bjp-19065	6	25	(	(	PUNCT
bjp-19065	6	26	zhou	zhou	PROPN
bjp-19065	6	27	et	et	PROPN
bjp-19065	6	28	al	al	PROPN
bjp-19065	6	29	.	.	PROPN
bjp-19065	6	30	,	,	PUNCT
bjp-19065	6	31	2007	2007	NUM
bjp-19065	6	32	)	)	PUNCT
bjp-19065	6	33	,	,	PUNCT
bjp-19065	6	34	anemia	anemia	NOUN
bjp-19065	6	35	(	(	PUNCT
bjp-19065	6	36	hochberg	hochberg	PROPN
bjp-19065	6	37	et	et	PROPN
bjp-19065	6	38	al	al	PROPN
bjp-19065	6	39	.	.	PROPN
bjp-19065	6	40	,	,	PUNCT
bjp-19065	6	41	1988	1988	NUM
bjp-19065	6	42	)	)	PUNCT
bjp-19065	6	43	and	and	CCONJ
bjp-19065	6	44	hypolepidemia	hypolepidemia	NOUN
bjp-19065	6	45	(	(	PUNCT
bjp-19065	6	46	hashizume	hashizume	NOUN
bjp-19065	6	47	et	et	PROPN
bjp-19065	6	48	al	al	PROPN
bjp-19065	6	49	.	.	PROPN
bjp-19065	6	50	,	,	PUNCT
bjp-19065	6	51	2010	2010	NUM
bjp-19065	6	52	)	)	PUNCT
bjp-19065	6	53	makes	make	VERB
bjp-19065	6	54	it	it	PRON
bjp-19065	6	55	a	a	DET
bjp-19065	6	56	potential	potential	ADJ
bjp-19065	6	57	target	target	NOUN
bjp-19065	6	58	in	in	ADP
bjp-19065	6	59	treatment	treatment	NOUN
bjp-19065	6	60	of	of	ADP
bjp-19065	6	61	rheumatoid	rheumatoid	NOUN
bjp-19065	6	62	arthritis	arthritis	NOUN
bjp-19065	6	63	.	.	PUNCT
bjp-19065	7	1	the	the	DET
bjp-19065	7	2	argentine	argentine	PROPN
bjp-19065	7	3	(	(	PUNCT
bjp-19065	7	4	arg	arg	NOUN
bjp-19065	7	5	)	)	PUNCT
bjp-19065	7	6	at	at	ADP
bjp-19065	7	7	the	the	DET
bjp-19065	7	8	179th	179th	ADJ
bjp-19065	7	9	position	position	NOUN
bjp-19065	7	10	of	of	ADP
bjp-19065	7	11	il-6	il-6	NOUN
bjp-19065	7	12	plays	play	VERB
bjp-19065	7	13	an	an	DET
bjp-19065	7	14	important	important	ADJ
bjp-19065	7	15	role	role	NOUN
bjp-19065	7	16	(	(	PUNCT
bjp-19065	7	17	fontaine	fontaine	PROPN
bjp-19065	7	18	et	et	PROPN
bjp-19065	7	19	al	al	PROPN
bjp-19065	7	20	.	.	PROPN
bjp-19065	7	21	1992	1992	NUM
bjp-19065	7	22	)	)	PUNCT
bjp-19065	7	23	,	,	PUNCT
bjp-19065	7	24	targeting	target	VERB
bjp-19065	7	25	this	this	DET
bjp-19065	7	26	particular	particular	ADJ
bjp-19065	7	27	site	site	NOUN
bjp-19065	7	28	in	in	ADP
bjp-19065	7	29	il-6	il-6	NUM
bjp-19065	7	30	will	will	AUX
bjp-19065	7	31	impair	impair	VERB
bjp-19065	7	32	its	its	PRON
bjp-19065	7	33	normal	normal	ADJ
bjp-19065	7	34	functioning	functioning	NOUN
bjp-19065	7	35	.	.	PUNCT
bjp-19065	8	1	to	to	PART
bjp-19065	8	2	achieve	achieve	VERB
bjp-19065	8	3	this	this	PRON
bjp-19065	8	4	we	we	PRON
bjp-19065	8	5	resorted	resort	VERB
bjp-19065	8	6	to	to	AUX
bjp-19065	8	7	computer	computer	NOUN
bjp-19065	8	8	aided	aid	VERB
bjp-19065	8	9	drug	drug	NOUN
bjp-19065	8	10	discovery	discovery	NOUN
bjp-19065	8	11	,	,	PUNCT
bjp-19065	8	12	which	which	PRON
bjp-19065	8	13	has	have	AUX
bjp-19065	8	14	become	become	VERB
bjp-19065	8	15	an	an	DET
bjp-19065	8	16	important	important	ADJ
bjp-19065	8	17	tool	tool	NOUN
bjp-19065	8	18	in	in	ADP
bjp-19065	8	19	drug	drug	NOUN
bjp-19065	8	20	discovery	discovery	NOUN
bjp-19065	8	21	(	(	PUNCT
bjp-19065	8	22	alvarez	alvarez	PROPN
bjp-19065	8	23	,	,	PUNCT
bjp-19065	8	24	2004	2004	NUM
bjp-19065	8	25	;	;	PUNCT
bjp-19065	8	26	chikan	chikan	PROPN
bjp-19065	8	27	et	et	PROPN
bjp-19065	8	28	al	al	PROPN
bjp-19065	8	29	.	.	PROPN
bjp-19065	8	30	,	,	PUNCT
bjp-19065	8	31	2013	2013	NUM
bjp-19065	8	32	)	)	PUNCT
bjp-19065	8	33	.	.	PUNCT
bjp-19065	9	1	the	the	DET
bjp-19065	9	2	present	present	ADJ
bjp-19065	9	3	study	study	NOUN
bjp-19065	9	4	targeted	target	VERB
bjp-19065	9	5	crystal	crystal	NOUN
bjp-19065	9	6	structure	structure	NOUN
bjp-19065	9	7	of	of	ADP
bjp-19065	9	8	il-6	il-6	NOUN
bjp-19065	9	9	bearing	bear	VERB
bjp-19065	9	10	accession	accession	NOUN
bjp-19065	9	11	code	code	NOUN
bjp-19065	9	12	of	of	ADP
bjp-19065	9	13	1alu	1alu	NUM
bjp-19065	9	14	(	(	PUNCT
bjp-19065	9	15	somers	somer	NOUN
bjp-19065	9	16	et	et	PROPN
bjp-19065	9	17	al	al	PROPN
bjp-19065	9	18	.	.	PROPN
bjp-19065	9	19	,	,	PUNCT
bjp-19065	9	20	1997	1997	NUM
bjp-19065	9	21	)	)	PUNCT
bjp-19065	9	22	,	,	PUNCT
bjp-19065	9	23	to	to	PART
bjp-19065	9	24	obtain	obtain	VERB
bjp-19065	9	25	the	the	DET
bjp-19065	9	26	selected	select	VERB
bjp-19065	9	27	few	few	ADJ
bjp-19065	9	28	lead	lead	NOUN
bjp-19065	9	29	compounds	compound	NOUN
bjp-19065	9	30	of	of	ADP
bjp-19065	9	31	natural	natural	ADJ
bjp-19065	9	32	origin	origin	NOUN
bjp-19065	9	33	.	.	PUNCT
bjp-19065	10	1	to	to	PART
bjp-19065	10	2	achieve	achieve	VERB
bjp-19065	10	3	our	our	PRON
bjp-19065	10	4	goal	goal	NOUN
bjp-19065	10	5	we	we	PRON
bjp-19065	10	6	used	use	VERB
bjp-19065	10	7	multistep	multistep	NOUN
bjp-19065	10	8	structurebased	structurebase	VERB
bjp-19065	10	9	virtual	virtual	ADJ
bjp-19065	10	10	screening	screening	NOUN
bjp-19065	10	11	of	of	ADP
bjp-19065	10	12	around	around	ADV
bjp-19065	10	13	fifty	fifty	NUM
bjp-19065	10	14	thousand	thousand	NUM
bjp-19065	10	15	natural	natural	ADJ
bjp-19065	10	16	compounds	compound	NOUN
bjp-19065	10	17	obtained	obtain	VERB
bjp-19065	10	18	from	from	ADP
bjp-19065	10	19	inter	inter	PROPN
bjp-19065	10	20	bio	bio	PROPN
bjp-19065	10	21	screen	screen	PROPN
bjp-19065	10	22	(	(	PUNCT
bjp-19065	10	23	ibs	ibs	PROPN
bjp-19065	10	24	)	)	PUNCT
bjp-19065	10	25	database	database	NOUN
bjp-19065	10	26	.	.	PUNCT
bjp-19065	11	1	virtual	virtual	ADJ
bjp-19065	11	2	screening	screening	NOUN
bjp-19065	11	3	which	which	PRON
bjp-19065	11	4	is	be	AUX
bjp-19065	11	5	incorporated	incorporate	VERB
bjp-19065	11	6	in	in	ADP
bjp-19065	11	7	the	the	DET
bjp-19065	11	8	major	major	ADJ
bjp-19065	11	9	pipeline	pipeline	NOUN
bjp-19065	11	10	of	of	ADP
bjp-19065	11	11	drug	drug	NOUN
bjp-19065	11	12	discovery	discovery	NOUN
bjp-19065	11	13	in	in	ADP
bjp-19065	11	14	most	most	ADJ
bjp-19065	11	15	pharmaceutical	pharmaceutical	ADJ
bjp-19065	11	16	companies	company	NOUN
bjp-19065	11	17	has	have	AUX
bjp-19065	11	18	become	become	VERB
bjp-19065	11	19	an	an	DET
bjp-19065	11	20	indispensible	indispensible	ADJ
bjp-19065	11	21	tool	tool	NOUN
bjp-19065	11	22	for	for	ADP
bjp-19065	11	23	iden	iden	PROPN
bjp-19065	11	24	-tifying	-tifye	VERB
bjp-19065	11	25	active	active	ADJ
bjp-19065	11	26	lead	lead	NOUN
bjp-19065	11	27	compounds	compound	NOUN
bjp-19065	11	28	.	.	PUNCT
bjp-19065	12	1	the	the	DET
bjp-19065	12	2	absorption	absorption	NOUN
bjp-19065	12	3	,	,	PUNCT
bjp-19065	12	4	distribution	distribution	NOUN
bjp-19065	12	5	,	,	PUNCT
bjp-19065	12	6	metabolism	metabolism	NOUN
bjp-19065	12	7	,	,	PUNCT
bjp-19065	12	8	elimination	elimination	NOUN
bjp-19065	12	9	(	(	PUNCT
bjp-19065	12	10	adme	adme	NOUN
bjp-19065	12	11	)	)	PUNCT
bjp-19065	12	12	and	and	CCONJ
bjp-19065	12	13	toxicology	toxicology	NOUN
bjp-19065	12	14	(	(	PUNCT
bjp-19065	12	15	tox	tox	NOUN
bjp-19065	12	16	)	)	PUNCT
bjp-19065	12	17	are	be	AUX
bjp-19065	12	18	also	also	ADV
bjp-19065	12	19	the	the	DET
bjp-19065	12	20	properties	property	NOUN
bjp-19065	12	21	that	that	PRON
bjp-19065	12	22	have	have	AUX
bjp-19065	12	23	been	be	AUX
bjp-19065	12	24	identified	identify	VERB
bjp-19065	12	25	as	as	ADP
bjp-19065	12	26	the	the	DET
bjp-19065	12	27	major	major	ADJ
bjp-19065	12	28	cause	cause	NOUN
bjp-19065	12	29	of	of	ADP
bjp-19065	12	30	failure	failure	NOUN
bjp-19065	12	31	of	of	ADP
bjp-19065	12	32	major	major	ADJ
bjp-19065	12	33	drug	drug	NOUN
bjp-19065	12	34	screening	screening	NOUN
bjp-19065	12	35	projects	project	NOUN
bjp-19065	12	36	(	(	PUNCT
bjp-19065	12	37	davis	davis	PROPN
bjp-19065	12	38	et	et	PROPN
bjp-19065	12	39	al	al	PROPN
bjp-19065	12	40	.	.	PROPN
bjp-19065	12	41	,	,	PUNCT
bjp-19065	12	42	2004	2004	NUM
bjp-19065	12	43	)	)	PUNCT
bjp-19065	12	44	therefore	therefore	ADV
bjp-19065	12	45	adme	adme	PROPN
bjp-19065	12	46	/	/	SYM
bjp-19065	12	47	tox	tox	PROPN
bjp-19065	12	48	data	datum	NOUN
bjp-19065	12	49	validation	validation	NOUN
bjp-19065	12	50	is	be	AUX
bjp-19065	12	51	an	an	DET
bjp-19065	12	52	important	important	ADJ
bjp-19065	12	53	aspect	aspect	NOUN
bjp-19065	12	54	(	(	PUNCT
bjp-19065	12	55	van	van	PROPN
bjp-19065	12	56	et	et	PROPN
bjp-19065	12	57	al	al	PROPN
bjp-19065	12	58	.	.	PROPN
bjp-19065	12	59	,	,	PUNCT
bjp-19065	12	60	2003	2003	NUM
bjp-19065	12	61	)	)	PUNCT
bjp-19065	12	62	.	.	PUNCT
bjp-19065	13	1	material	material	NOUN
bjp-19065	13	2	and	and	CCONJ
bjp-19065	13	3	methods	method	NOUN
bjp-19065	13	4	the	the	DET
bjp-19065	13	5	crystal	crystal	NOUN
bjp-19065	13	6	structure	structure	NOUN
bjp-19065	13	7	of	of	ADP
bjp-19065	13	8	human	human	ADJ
bjp-19065	13	9	il-6	il-6	NOUN
bjp-19065	13	10	protein	protein	NOUN
bjp-19065	13	11	(	(	PUNCT
bjp-19065	13	12	pdb	pdb	PROPN
bjp-19065	13	13	i	i	PROPN
bjp-19065	13	14	d	d	PROPN
bjp-19065	13	15	:	:	PUNCT
bjp-19065	13	16	1alu	1alu	NUM
bjp-19065	13	17	)	)	PUNCT
bjp-19065	13	18	was	be	AUX
bjp-19065	13	19	obtained	obtain	VERB
bjp-19065	13	20	from	from	ADP
bjp-19065	13	21	protein	protein	NOUN
bjp-19065	13	22	databank	databank	NOUN
bjp-19065	13	23	(	(	PUNCT
bjp-19065	13	24	pdb	pdb	PROPN
bjp-19065	13	25	)	)	PUNCT
bjp-19065	13	26	.	.	PUNCT
bjp-19065	14	1	a	a	DET
bjp-19065	14	2	journal	journal	NOUN
bjp-19065	14	3	of	of	ADP
bjp-19065	14	4	the	the	DET
bjp-19065	14	5	bangladesh	bangladesh	NOUN
bjp-19065	14	6	pharmacological	pharmacological	ADJ
bjp-19065	14	7	society	society	NOUN
bjp-19065	14	8	(	(	PUNCT
bjp-19065	14	9	bdps	bdps	NOUN
bjp-19065	14	10	)	)	PUNCT
bjp-19065	14	11	bangladesh	bangladesh	PROPN
bjp-19065	14	12	j	j	PROPN
bjp-19065	14	13	pharmacol	pharmacol	PROPN
bjp-19065	14	14	2014	2014	NUM
bjp-19065	14	15	;	;	PUNCT
bjp-19065	14	16	9	9	NUM
bjp-19065	14	17	:	:	SYM
bjp-19065	14	18	371	371	NUM
bjp-19065	14	19	-	-	SYM
bjp-19065	14	20	376	376	NUM
bjp-19065	14	21	journal	journal	NOUN
bjp-19065	14	22	homepage	homepage	NOUN
bjp-19065	14	23	:	:	PUNCT
bjp-19065	14	24	www.banglajol.info	www.banglajol.info	PROPN
bjp-19065	14	25	abstracted	abstract	VERB
bjp-19065	14	26	/	/	SYM
bjp-19065	14	27	indexed	index	VERB
bjp-19065	14	28	in	in	ADP
bjp-19065	14	29	academic	academic	ADJ
bjp-19065	14	30	search	search	NOUN
bjp-19065	14	31	complete	complete	ADJ
bjp-19065	14	32	,	,	PUNCT
bjp-19065	14	33	agroforestry	agroforestry	NOUN
bjp-19065	14	34	abstracts	abstract	NOUN
bjp-19065	14	35	,	,	PUNCT
bjp-19065	14	36	asia	asia	PROPN
bjp-19065	14	37	journals	journal	NOUN
bjp-19065	14	38	online	online	ADV
bjp-19065	14	39	,	,	PUNCT
bjp-19065	14	40	bangladesh	bangladesh	NOUN
bjp-19065	14	41	journals	journal	NOUN
bjp-19065	14	42	online	online	ADV
bjp-19065	14	43	,	,	PUNCT
bjp-19065	14	44	biological	biological	ADJ
bjp-19065	14	45	abstracts	abstract	NOUN
bjp-19065	14	46	,	,	PUNCT
bjp-19065	14	47	biosis	biosis	NOUN
bjp-19065	14	48	previews	preview	NOUN
bjp-19065	14	49	,	,	PUNCT
bjp-19065	14	50	cab	cab	NOUN
bjp-19065	14	51	abstracts	abstract	NOUN
bjp-19065	14	52	,	,	PUNCT
bjp-19065	14	53	current	current	ADJ
bjp-19065	14	54	abstracts	abstract	NOUN
bjp-19065	14	55	,	,	PUNCT
bjp-19065	14	56	directory	directory	NOUN
bjp-19065	14	57	of	of	ADP
bjp-19065	14	58	open	open	ADJ
bjp-19065	14	59	access	access	NOUN
bjp-19065	14	60	journals	journal	NOUN
bjp-19065	14	61	,	,	PUNCT
bjp-19065	14	62	embase	embase	NOUN
bjp-19065	14	63	/	/	SYM
bjp-19065	14	64	excerpta	excerpta	NOUN
bjp-19065	14	65	medica	medica	NOUN
bjp-19065	14	66	,	,	PUNCT
bjp-19065	14	67	global	global	ADJ
bjp-19065	14	68	health	health	NOUN
bjp-19065	14	69	,	,	PUNCT
bjp-19065	14	70	google	google	PROPN
bjp-19065	14	71	scholar	scholar	NOUN
bjp-19065	14	72	,	,	PUNCT
bjp-19065	14	73	hinari	hinari	X
bjp-19065	14	74	(	(	PUNCT
bjp-19065	14	75	who	who	PRON
bjp-19065	14	76	)	)	PUNCT
bjp-19065	14	77	,	,	PUNCT
bjp-19065	14	78	international	international	ADJ
bjp-19065	14	79	pharmaceutical	pharmaceutical	ADJ
bjp-19065	14	80	abstracts	abstract	NOUN
bjp-19065	14	81	,	,	PUNCT
bjp-19065	14	82	open	open	ADJ
bjp-19065	14	83	j	j	PROPN
bjp-19065	14	84	-	-	PUNCT
bjp-19065	14	85	gate	gate	NOUN
bjp-19065	14	86	,	,	PUNCT
bjp-19065	14	87	science	science	NOUN
bjp-19065	14	88	citation	citation	NOUN
bjp-19065	14	89	index	index	NOUN
bjp-19065	14	90	expanded	expand	VERB
bjp-19065	14	91	,	,	PUNCT
bjp-19065	14	92	scopus	scopus	NOUN
bjp-19065	14	93	and	and	CCONJ
bjp-19065	14	94	social	social	ADJ
bjp-19065	14	95	sciences	sciences	PROPN
bjp-19065	14	96	citation	citation	NOUN
bjp-19065	14	97	index	index	NOUN
bjp-19065	14	98	issn	issn	PROPN
bjp-19065	14	99	:	:	PUNCT
bjp-19065	14	100	1991	1991	NUM
bjp-19065	14	101	-	-	PUNCT
bjp-19065	14	102	0088	0088	NUM
bjp-19065	14	103	abstract	abstract	ADJ
bjp-19065	14	104	rheumatoid	rheumatoid	VERB
bjp-19065	14	105	arthritis	arthritis	NOUN
bjp-19065	14	106	an	an	DET
bjp-19065	14	107	autoimmune	autoimmune	ADJ
bjp-19065	14	108	disorder	disorder	NOUN
bjp-19065	14	109	affecting	affect	VERB
bjp-19065	14	110	many	many	ADJ
bjp-19065	14	111	tissues	tissue	NOUN
bjp-19065	14	112	and	and	CCONJ
bjp-19065	14	113	organs	organ	NOUN
bjp-19065	14	114	,	,	PUNCT
bjp-19065	14	115	is	be	AUX
bjp-19065	14	116	a	a	DET
bjp-19065	14	117	challenging	challenging	ADJ
bjp-19065	14	118	prospect	prospect	NOUN
bjp-19065	14	119	in	in	ADP
bjp-19065	14	120	terms	term	NOUN
bjp-19065	14	121	of	of	ADP
bjp-19065	14	122	treatment	treatment	NOUN
bjp-19065	14	123	.	.	PUNCT
bjp-19065	15	1	our	our	PRON
bjp-19065	15	2	work	work	NOUN
bjp-19065	15	3	is	be	AUX
bjp-19065	15	4	looking	look	VERB
bjp-19065	15	5	into	into	ADP
bjp-19065	15	6	finding	find	VERB
bjp-19065	15	7	lead	lead	NOUN
bjp-19065	15	8	compound	compound	NOUN
bjp-19065	15	9	of	of	ADP
bjp-19065	15	10	natural	natural	ADJ
bjp-19065	15	11	origin	origin	NOUN
bjp-19065	15	12	against	against	ADP
bjp-19065	15	13	il-6	il-6	NUM
bjp-19065	15	14	,	,	PUNCT
bjp-19065	15	15	an	an	DET
bjp-19065	15	16	important	important	ADJ
bjp-19065	15	17	cytokine	cytokine	NOUN
bjp-19065	15	18	having	have	VERB
bjp-19065	15	19	a	a	DET
bjp-19065	15	20	profound	profound	ADJ
bjp-19065	15	21	role	role	NOUN
bjp-19065	15	22	in	in	ADP
bjp-19065	15	23	pathogenesis	pathogenesis	NOUN
bjp-19065	15	24	of	of	ADP
bjp-19065	15	25	rheumatoid	rheumatoid	NOUN
bjp-19065	15	26	arthritis	arthritis	NOUN
bjp-19065	15	27	.	.	PUNCT
bjp-19065	16	1	for	for	ADP
bjp-19065	16	2	this	this	DET
bjp-19065	16	3	purpose	purpose	NOUN
bjp-19065	16	4	we	we	PRON
bjp-19065	16	5	have	have	AUX
bjp-19065	16	6	targeted	target	VERB
bjp-19065	16	7	the	the	DET
bjp-19065	16	8	active	active	ADJ
bjp-19065	16	9	site	site	NOUN
bjp-19065	16	10	(	(	PUNCT
bjp-19065	16	11	arg	arg	NOUN
bjp-19065	16	12	179	179	NUM
bjp-19065	16	13	)	)	PUNCT
bjp-19065	16	14	of	of	ADP
bjp-19065	16	15	il-6	il-6	NOUN
bjp-19065	16	16	using	use	VERB
bjp-19065	16	17	ibs	ibs	PROPN
bjp-19065	16	18	database	database	NOUN
bjp-19065	16	19	having	have	VERB
bjp-19065	16	20	48531	48531	NUM
bjp-19065	16	21	natural	natural	ADJ
bjp-19065	16	22	compounds	compound	NOUN
bjp-19065	16	23	.	.	PUNCT
bjp-19065	17	1	computer	computer	NOUN
bjp-19065	17	2	aided	aid	VERB
bjp-19065	17	3	drug	drug	NOUN
bjp-19065	17	4	designing	designing	NOUN
bjp-19065	17	5	methods	method	NOUN
bjp-19065	17	6	of	of	ADP
bjp-19065	17	7	virtual	virtual	ADJ
bjp-19065	17	8	screening	screening	NOUN
bjp-19065	17	9	and	and	CCONJ
bjp-19065	17	10	in	in	ADP
bjp-19065	17	11	silico	silico	NOUN
bjp-19065	17	12	adme	adme	NOUN
bjp-19065	17	13	/	/	SYM
bjp-19065	17	14	tox	tox	PROPN
bjp-19065	17	15	helped	help	VERB
bjp-19065	17	16	us	we	PRON
bjp-19065	17	17	to	to	PART
bjp-19065	17	18	limit	limit	VERB
bjp-19065	17	19	our	our	PRON
bjp-19065	17	20	study	study	NOUN
bjp-19065	17	21	of	of	ADP
bjp-19065	17	22	molecular	molecular	ADJ
bjp-19065	17	23	docking	docking	NOUN
bjp-19065	17	24	to	to	PART
bjp-19065	17	25	selected	select	VERB
bjp-19065	17	26	few	few	ADJ
bjp-19065	17	27	for	for	ADP
bjp-19065	17	28	an	an	DET
bjp-19065	17	29	atomic	atomic	ADJ
bjp-19065	17	30	insight	insight	NOUN
bjp-19065	17	31	into	into	ADP
bjp-19065	17	32	their	their	PRON
bjp-19065	17	33	binding	bind	VERB
bjp-19065	17	34	modes	mode	NOUN
bjp-19065	17	35	.	.	PUNCT
bjp-19065	18	1	the	the	DET
bjp-19065	18	2	molecular	molecular	ADJ
bjp-19065	18	3	docking	docking	NOUN
bjp-19065	18	4	analysis	analysis	NOUN
bjp-19065	18	5	helped	help	VERB
bjp-19065	18	6	us	we	PRON
bjp-19065	18	7	to	to	PART
bjp-19065	18	8	propose	propose	VERB
bjp-19065	18	9	five	five	NUM
bjp-19065	18	10	possible	possible	ADJ
bjp-19065	18	11	drugs	drug	NOUN
bjp-19065	18	12	,	,	PUNCT
bjp-19065	18	13	out	out	ADP
bjp-19065	18	14	of	of	ADP
bjp-19065	18	15	which	which	PRON
bjp-19065	18	16	one	one	NUM
bjp-19065	18	17	compound	compound	NOUN
bjp-19065	18	18	(	(	PUNCT
bjp-19065	18	19	chem	chem	NOUN
bjp-19065	18	20	.	.	PUNCT
bjp-19065	19	1	i	i	PRON
bjp-19065	19	2	d	d	PROPN
bjp-19065	19	3	10465	10465	NUM
bjp-19065	19	4	)	)	PUNCT
bjp-19065	19	5	margaric	margaric	ADJ
bjp-19065	19	6	acid	acid	NOUN
bjp-19065	19	7	is	be	AUX
bjp-19065	19	8	an	an	DET
bjp-19065	19	9	edible	edible	ADJ
bjp-19065	19	10	fatty	fatty	NOUN
bjp-19065	19	11	acid	acid	NOUN
bjp-19065	19	12	and	and	CCONJ
bjp-19065	19	13	exhibited	exhibit	VERB
bjp-19065	19	14	good	good	ADJ
bjp-19065	19	15	binding	bind	VERB
bjp-19065	19	16	affinity	affinity	NOUN
bjp-19065	19	17	with	with	ADP
bjp-19065	19	18	the	the	DET
bjp-19065	19	19	active	active	ADJ
bjp-19065	19	20	site	site	NOUN
bjp-19065	19	21	of	of	ADP
bjp-19065	19	22	il6	il6	NOUN
bjp-19065	19	23	,	,	PUNCT
bjp-19065	19	24	thus	thus	ADV
bjp-19065	19	25	making	make	VERB
bjp-19065	19	26	it	it	PRON
bjp-19065	19	27	a	a	DET
bjp-19065	19	28	good	good	ADJ
bjp-19065	19	29	starting	starting	NOUN
bjp-19065	19	30	point	point	NOUN
bjp-19065	19	31	for	for	ADP
bjp-19065	19	32	developing	develop	VERB
bjp-19065	19	33	drug	drug	NOUN
bjp-19065	19	34	for	for	ADP
bjp-19065	19	35	treatment	treatment	NOUN
bjp-19065	19	36	of	of	ADP
bjp-19065	19	37	arthritis	arthritis	NOUN
bjp-19065	19	38	.	.	PUNCT
bjp-19065	20	1	article	article	NOUN
bjp-19065	20	2	info	info	NOUN
bjp-19065	20	3	received	receive	VERB
bjp-19065	20	4	:	:	PUNCT
bjp-19065	20	5	5	5	NUM
bjp-19065	20	6	june	june	PROPN
bjp-19065	20	7	2014	2014	NUM
bjp-19065	20	8	accepted	accept	VERB
bjp-19065	20	9	:	:	PUNCT
bjp-19065	20	10	17	17	NUM
bjp-19065	20	11	june	june	PROPN
bjp-19065	20	12	2014	2014	NUM
bjp-19065	20	13	available	available	ADJ
bjp-19065	20	14	online	online	NOUN
bjp-19065	20	15	:	:	PUNCT
bjp-19065	20	16	20	20	NUM
bjp-19065	20	17	august	august	PROPN
bjp-19065	20	18	2014	2014	NUM
bjp-19065	20	19	doi	doi	NOUN
bjp-19065	20	20	:	:	PUNCT
bjp-19065	20	21	10.3329	10.3329	NUM
bjp-19065	20	22	/	/	SYM
bjp-19065	20	23	bjp.v9i3.19065	bjp.v9i3.19065	PROPN
bjp-19065	20	24	cite	cite	VERB
bjp-19065	20	25	this	this	DET
bjp-19065	20	26	article	article	NOUN
bjp-19065	20	27	:	:	PUNCT
bjp-19065	20	28	zhou	zhou	PROPN
bjp-19065	20	29	w	w	PROPN
bjp-19065	20	30	,	,	PUNCT
bjp-19065	20	31	cai	cai	PROPN
bjp-19065	20	32	jf	jf	PROPN
bjp-19065	20	33	,	,	PUNCT
bjp-19065	20	34	yuan	yuan	PROPN
bjp-19065	20	35	f	f	PROPN
bjp-19065	20	36	,	,	PUNCT
bjp-19065	20	37	ma	ma	PROPN
bjp-19065	20	38	m	m	PROPN
bjp-19065	20	39	,	,	PUNCT
bjp-19065	20	40	yin	yin	PROPN
bjp-19065	20	41	f.	f.	PROPN
bjp-19065	20	42	in	in	ADP
bjp-19065	20	43	silico	silico	NOUN
bjp-19065	20	44	targeting	target	VERB
bjp-19065	20	45	of	of	ADP
bjp-19065	20	46	interleukin-6	interleukin-6	NUM
bjp-19065	20	47	by	by	ADP
bjp-19065	20	48	natural	natural	ADJ
bjp-19065	20	49	compounds	compound	NOUN
bjp-19065	20	50	.	.	PUNCT
bjp-19065	21	1	bangladesh	bangladesh	PROPN
bjp-19065	21	2	j	j	PROPN
bjp-19065	21	3	pharmacol	pharmacol	PROPN
bjp-19065	21	4	.	.	PUNCT
bjp-19065	21	5	2014	2014	NUM
bjp-19065	21	6	;	;	PUNCT
bjp-19065	21	7	9	9	NUM
bjp-19065	21	8	:	:	SYM
bjp-19065	21	9	371	371	NUM
bjp-19065	21	10	-	-	SYM
bjp-19065	21	11	76	76	NUM
bjp-19065	21	12	.	.	PUNCT
bjp-19065	22	1	this	this	DET
bjp-19065	22	2	work	work	NOUN
bjp-19065	22	3	is	be	AUX
bjp-19065	22	4	licensed	license	VERB
bjp-19065	22	5	under	under	ADP
bjp-19065	22	6	a	a	DET
bjp-19065	22	7	creative	creative	ADJ
bjp-19065	22	8	commons	common	NOUN
bjp-19065	22	9	attribution	attribution	NOUN
bjp-19065	22	10	3.0	3.0	NUM
bjp-19065	22	11	license	license	NOUN
bjp-19065	22	12	.	.	PUNCT
bjp-19065	23	1	you	you	PRON
bjp-19065	23	2	are	be	AUX
bjp-19065	23	3	free	free	ADJ
bjp-19065	23	4	to	to	PART
bjp-19065	23	5	copy	copy	VERB
bjp-19065	23	6	,	,	PUNCT
bjp-19065	23	7	distribute	distribute	VERB
bjp-19065	23	8	and	and	CCONJ
bjp-19065	23	9	perform	perform	VERB
bjp-19065	23	10	the	the	DET
bjp-19065	23	11	work	work	NOUN
bjp-19065	23	12	.	.	PUNCT
bjp-19065	24	1	you	you	PRON
bjp-19065	24	2	must	must	AUX
bjp-19065	24	3	attribute	attribute	VERB
bjp-19065	24	4	the	the	DET
bjp-19065	24	5	work	work	NOUN
bjp-19065	24	6	in	in	ADP
bjp-19065	24	7	the	the	DET
bjp-19065	24	8	manner	manner	NOUN
bjp-19065	24	9	specified	specify	VERB
bjp-19065	24	10	by	by	ADP
bjp-19065	24	11	the	the	DET
bjp-19065	24	12	author	author	NOUN
bjp-19065	24	13	or	or	CCONJ
bjp-19065	24	14	licensor	licensor	NOUN
bjp-19065	24	15	.	.	PUNCT
bjp-19065	25	1	in	in	ADP
bjp-19065	25	2	silico	silico	NOUN
bjp-19065	25	3	targeting	target	VERB
bjp-19065	25	4	of	of	ADP
bjp-19065	25	5	interleukin-6	interleukin-6	NUM
bjp-19065	25	6	by	by	ADP
bjp-19065	25	7	natural	natural	ADJ
bjp-19065	25	8	compounds	compound	NOUN
bjp-19065	25	9	wei	wei	PROPN
bjp-19065	25	10	zhou	zhou	PROPN
bjp-19065	25	11	,	,	PUNCT
bjp-19065	25	12	jun	jun	PROPN
bjp-19065	25	13	feng	feng	PROPN
bjp-19065	25	14	cai	cai	PROPN
bjp-19065	25	15	,	,	PUNCT
bjp-19065	25	16	feng	feng	PROPN
bjp-19065	25	17	yuan	yuan	PROPN
bjp-19065	25	18	,	,	PUNCT
bjp-19065	25	19	min	min	PROPN
bjp-19065	25	20	ma	ma	PROPN
bjp-19065	25	21	and	and	CCONJ
bjp-19065	25	22	feng	feng	PROPN
bjp-19065	25	23	yin	yin	PROPN
bjp-19065	25	24	department	department	PROPN
bjp-19065	25	25	of	of	ADP
bjp-19065	25	26	osteoarthritis	osteoarthritis	PROPN
bjp-19065	25	27	,	,	PUNCT
bjp-19065	25	28	shanghai	shanghai	PROPN
bjp-19065	25	29	oriental	oriental	PROPN
bjp-19065	25	30	hospital	hospital	PROPN
bjp-19065	25	31	,	,	PUNCT
bjp-19065	25	32	shanghai	shanghai	PROPN
bjp-19065	25	33	200120	200120	NUM
bjp-19065	25	34	,	,	PUNCT
bjp-19065	25	35	china	china	PROPN
bjp-19065	25	36	.	.	PUNCT
bjp-19065	26	1	spdb	spdb	ADV
bjp-19065	26	2	viewer	viewer	VERB
bjp-19065	26	3	at	at	ADP
bjp-19065	26	4	the	the	DET
bjp-19065	26	5	default	default	NOUN
bjp-19065	26	6	cut	cut	VERB
bjp-19065	26	7	off	off	ADP
bjp-19065	26	8	rmsd	rmsd	X
bjp-19065	26	9	(	(	PUNCT
bjp-19065	26	10	root	root	NOUN
bjp-19065	26	11	mean	mean	ADJ
bjp-19065	26	12	square	square	ADJ
bjp-19065	26	13	deviation	deviation	NOUN
bjp-19065	26	14	)	)	PUNCT
bjp-19065	26	15	value	value	NOUN
bjp-19065	26	16	of	of	ADP
bjp-19065	26	17	0.5	0.5	NUM
bjp-19065	26	18	ǻ	ǻ	NOUN
bjp-19065	26	19	using	use	VERB
bjp-19065	26	20	opls	opls	NOUN
bjp-19065	26	21	2001	2001	NUM
bjp-19065	26	22	force	force	NOUN
bjp-19065	26	23	field	field	NOUN
bjp-19065	26	24	was	be	AUX
bjp-19065	26	25	used	use	VERB
bjp-19065	26	26	for	for	ADP
bjp-19065	26	27	energy	energy	NOUN
bjp-19065	26	28	minimization	minimization	NOUN
bjp-19065	26	29	of	of	ADP
bjp-19065	26	30	the	the	DET
bjp-19065	26	31	pdb	pdb	PROPN
bjp-19065	26	32	structure	structure	NOUN
bjp-19065	26	33	.	.	PUNCT
bjp-19065	27	1	the	the	DET
bjp-19065	27	2	modus	modus	ADJ
bjp-19065	27	3	operandi	operandi	NOUN
bjp-19065	27	4	that	that	PRON
bjp-19065	27	5	followed	follow	VERB
bjp-19065	27	6	this	this	DET
bjp-19065	27	7	step	step	NOUN
bjp-19065	27	8	is	be	AUX
bjp-19065	27	9	illustrated	illustrate	VERB
bjp-19065	27	10	in	in	ADP
bjp-19065	27	11	figure	figure	NOUN
bjp-19065	27	12	1	1	NUM
bjp-19065	27	13	.	.	X
bjp-19065	27	14	virtual	virtual	ADJ
bjp-19065	27	15	screening	screening	NOUN
bjp-19065	27	16	(	(	PUNCT
bjp-19065	27	17	vs	vs	NOUN
bjp-19065	27	18	)	)	PUNCT
bjp-19065	27	19	virtual	virtual	ADJ
bjp-19065	27	20	screening	screening	NOUN
bjp-19065	27	21	has	have	AUX
bjp-19065	27	22	become	become	VERB
bjp-19065	27	23	a	a	DET
bjp-19065	27	24	necessary	necessary	ADJ
bjp-19065	27	25	tool	tool	NOUN
bjp-19065	27	26	in	in	ADP
bjp-19065	27	27	cutting	cut	VERB
bjp-19065	27	28	short	short	ADJ
bjp-19065	27	29	lead	lead	NOUN
bjp-19065	27	30	compounds	compound	NOUN
bjp-19065	27	31	and	and	CCONJ
bjp-19065	27	32	has	have	AUX
bjp-19065	27	33	fitted	fit	VERB
bjp-19065	27	34	itself	itself	PRON
bjp-19065	27	35	in	in	ADP
bjp-19065	27	36	the	the	DET
bjp-19065	27	37	pipeline	pipeline	NOUN
bjp-19065	27	38	of	of	ADP
bjp-19065	27	39	drug	drug	NOUN
bjp-19065	27	40	discovery	discovery	NOUN
bjp-19065	27	41	in	in	ADP
bjp-19065	27	42	most	most	ADJ
bjp-19065	27	43	pharmaceutical	pharmaceutical	ADJ
bjp-19065	27	44	companies	company	NOUN
bjp-19065	27	45	.	.	PUNCT
bjp-19065	28	1	we	we	PRON
bjp-19065	28	2	used	use	VERB
bjp-19065	28	3	arguslab	arguslab	PROPN
bjp-19065	28	4	(	(	PUNCT
bjp-19065	28	5	thompson	thompson	PROPN
bjp-19065	28	6	et	et	PROPN
bjp-19065	28	7	al	al	PROPN
bjp-19065	28	8	.	.	PROPN
bjp-19065	28	9	,	,	PUNCT
bjp-19065	28	10	2004	2004	NUM
bjp-19065	28	11	)	)	PUNCT
bjp-19065	28	12	to	to	PART
bjp-19065	28	13	perform	perform	VERB
bjp-19065	28	14	the	the	DET
bjp-19065	28	15	vs	vs	ADP
bjp-19065	28	16	of	of	ADP
bjp-19065	28	17	the	the	DET
bjp-19065	28	18	ligand	ligand	NOUN
bjp-19065	28	19	dataset	dataset	NOUN
bjp-19065	28	20	.	.	PUNCT
bjp-19065	29	1	the	the	DET
bjp-19065	29	2	software	software	NOUN
bjp-19065	29	3	was	be	AUX
bjp-19065	29	4	set	set	VERB
bjp-19065	29	5	to	to	ADP
bjp-19065	29	6	high	high	ADJ
bjp-19065	29	7	precision	precision	NOUN
bjp-19065	29	8	screening	screen	VERB
bjp-19065	29	9	using	use	VERB
bjp-19065	29	10	argusdock	argusdock	ADJ
bjp-19065	29	11	docking	docking	NOUN
bjp-19065	29	12	engine	engine	NOUN
bjp-19065	29	13	.	.	PUNCT
bjp-19065	30	1	the	the	DET
bjp-19065	30	2	ligands	ligand	NOUN
bjp-19065	30	3	were	be	AUX
bjp-19065	30	4	set	set	VERB
bjp-19065	30	5	to	to	ADP
bjp-19065	30	6	flexible	flexible	ADJ
bjp-19065	30	7	mode	mode	NOUN
bjp-19065	30	8	and	and	CCONJ
bjp-19065	30	9	were	be	AUX
bjp-19065	30	10	targeted	target	VERB
bjp-19065	30	11	against	against	ADP
bjp-19065	30	12	the	the	DET
bjp-19065	30	13	amino	amino	NOUN
bjp-19065	30	14	acid	acid	NOUN
bjp-19065	30	15	arg	arg	NOUN
bjp-19065	30	16	at	at	ADP
bjp-19065	30	17	179	179	NUM
bjp-19065	30	18	position	position	NOUN
bjp-19065	30	19	with	with	ADP
bjp-19065	30	20	a	a	DET
bjp-19065	30	21	grid	grid	NOUN
bjp-19065	30	22	box	box	NOUN
bjp-19065	30	23	of	of	ADP
bjp-19065	30	24	diameter	diameter	NOUN
bjp-19065	30	25	15	15	NUM
bjp-19065	30	26	x	x	SYM
bjp-19065	30	27	15	15	NUM
bjp-19065	30	28	x	x	SYM
bjp-19065	30	29	15	15	NUM
bjp-19065	30	30	ǻ	ǻ	NOUN
bjp-19065	30	31	.	.	PUNCT
bjp-19065	30	32	natural	natural	ADJ
bjp-19065	30	33	compounds	compound	NOUN
bjp-19065	30	34	from	from	ADP
bjp-19065	30	35	ibs	ib	NOUN
bjp-19065	30	36	database	database	NOUN
bjp-19065	30	37	,	,	PUNCT
bjp-19065	30	38	having	have	VERB
bjp-19065	30	39	48531	48531	NUM
bjp-19065	30	40	natural	natural	ADJ
bjp-19065	30	41	compounds	compound	NOUN
bjp-19065	30	42	were	be	AUX
bjp-19065	30	43	used	use	VERB
bjp-19065	30	44	for	for	ADP
bjp-19065	30	45	the	the	DET
bjp-19065	30	46	vs	vs	ADP
bjp-19065	30	47	of	of	ADP
bjp-19065	30	48	il-6	il-6	NOUN
bjp-19065	30	49	inhibitors	inhibitor	NOUN
bjp-19065	30	50	.	.	PUNCT
bjp-19065	31	1	from	from	ADP
bjp-19065	31	2	the	the	DET
bjp-19065	31	3	initial	initial	ADJ
bjp-19065	31	4	dataset	dataset	NOUN
bjp-19065	31	5	,	,	PUNCT
bjp-19065	31	6	a	a	DET
bjp-19065	31	7	total	total	NOUN
bjp-19065	31	8	of	of	ADP
bjp-19065	31	9	500	500	NUM
bjp-19065	31	10	compounds	compound	NOUN
bjp-19065	31	11	were	be	AUX
bjp-19065	31	12	selected	select	VERB
bjp-19065	31	13	based	base	VERB
bjp-19065	31	14	on	on	ADP
bjp-19065	31	15	their	their	PRON
bjp-19065	31	16	calculated	calculate	VERB
bjp-19065	31	17	binding	bind	VERB
bjp-19065	31	18	affinity	affinity	NOUN
bjp-19065	31	19	with	with	ADP
bjp-19065	31	20	the	the	DET
bjp-19065	31	21	protein	protein	NOUN
bjp-19065	31	22	il-6	il-6	NOUN
bjp-19065	31	23	for	for	ADP
bjp-19065	31	24	further	far	ADV
bjp-19065	31	25	in	in	ADP
bjp-19065	31	26	silico	silico	NOUN
bjp-19065	31	27	adme	adme	NOUN
bjp-19065	31	28	/	/	SYM
bjp-19065	31	29	tox	tox	NOUN
bjp-19065	31	30	analysis	analysis	NOUN
bjp-19065	31	31	.	.	PUNCT
bjp-19065	32	1	rule	rule	NOUN
bjp-19065	32	2	of	of	ADP
bjp-19065	32	3	five	five	NUM
bjp-19065	32	4	and	and	CCONJ
bjp-19065	32	5	adme	adme	PROPN
bjp-19065	32	6	/	/	SYM
bjp-19065	32	7	t	t	NOUN
bjp-19065	32	8	screening	screen	VERB
bjp-19065	32	9	the	the	DET
bjp-19065	32	10	subset	subset	NOUN
bjp-19065	32	11	of	of	ADP
bjp-19065	32	12	500	500	NUM
bjp-19065	32	13	compounds	compound	NOUN
bjp-19065	32	14	was	be	AUX
bjp-19065	32	15	screened	screen	VERB
bjp-19065	32	16	for	for	ADP
bjp-19065	32	17	lipinski	lipinski	PROPN
bjp-19065	32	18	rule	rule	NOUN
bjp-19065	32	19	of	of	ADP
bjp-19065	32	20	five	five	NUM
bjp-19065	32	21	violations	violation	NOUN
bjp-19065	32	22	(	(	PUNCT
bjp-19065	32	23	lipinski	lipinski	PROPN
bjp-19065	32	24	,	,	PUNCT
bjp-19065	32	25	2004	2004	NUM
bjp-19065	32	26	)	)	PUNCT
bjp-19065	32	27	with	with	ADP
bjp-19065	32	28	the	the	DET
bjp-19065	32	29	objective	objective	NOUN
bjp-19065	32	30	of	of	ADP
bjp-19065	32	31	increasing	increase	VERB
bjp-19065	32	32	the	the	DET
bjp-19065	32	33	success	success	NOUN
bjp-19065	32	34	rate	rate	NOUN
bjp-19065	32	35	of	of	ADP
bjp-19065	32	36	compounds	compound	NOUN
bjp-19065	32	37	reaching	reach	VERB
bjp-19065	32	38	further	further	ADJ
bjp-19065	32	39	stages	stage	NOUN
bjp-19065	32	40	of	of	ADP
bjp-19065	32	41	the	the	DET
bjp-19065	32	42	development	development	NOUN
bjp-19065	32	43	.	.	PUNCT
bjp-19065	33	1	the	the	DET
bjp-19065	33	2	subset	subset	NOUN
bjp-19065	33	3	of	of	ADP
bjp-19065	33	4	compounds	compound	NOUN
bjp-19065	33	5	was	be	AUX
bjp-19065	33	6	also	also	ADV
bjp-19065	33	7	subjected	subject	VERB
bjp-19065	33	8	to	to	ADP
bjp-19065	33	9	in	in	ADP
bjp-19065	33	10	silico	silico	NOUN
bjp-19065	33	11	prediction	prediction	NOUN
bjp-19065	33	12	(	(	PUNCT
bjp-19065	33	13	muanz	muanz	X
bjp-19065	33	14	et	et	PROPN
bjp-19065	33	15	al	al	PROPN
bjp-19065	33	16	.	.	PROPN
bjp-19065	33	17	,	,	PUNCT
bjp-19065	33	18	2013	2013	NUM
bjp-19065	33	19	)	)	PUNCT
bjp-19065	33	20	.	.	PUNCT
bjp-19065	34	1	a	a	DET
bjp-19065	34	2	total	total	NOUN
bjp-19065	34	3	of	of	ADP
bjp-19065	34	4	fifty	fifty	NUM
bjp-19065	34	5	top	top	ADJ
bjp-19065	34	6	compounds	compound	NOUN
bjp-19065	34	7	which	which	PRON
bjp-19065	34	8	satisfied	satisfy	VERB
bjp-19065	34	9	the	the	DET
bjp-19065	34	10	criteria	criterion	NOUN
bjp-19065	34	11	were	be	AUX
bjp-19065	34	12	chosen	choose	VERB
bjp-19065	34	13	for	for	ADP
bjp-19065	34	14	further	further	ADJ
bjp-19065	34	15	analysis	analysis	NOUN
bjp-19065	34	16	.	.	PUNCT
bjp-19065	35	1	molecular	molecular	ADJ
bjp-19065	35	2	docking	docking	NOUN
bjp-19065	35	3	autodock	autodock	NOUN
bjp-19065	35	4	4.2	4.2	NUM
bjp-19065	35	5	is	be	AUX
bjp-19065	35	6	used	use	VERB
bjp-19065	35	7	for	for	ADP
bjp-19065	35	8	molecular	molecular	ADJ
bjp-19065	35	9	docking	docking	NOUN
bjp-19065	35	10	(	(	PUNCT
bjp-19065	35	11	morris	morris	PROPN
bjp-19065	35	12	et	et	PROPN
bjp-19065	35	13	al	al	PROPN
bjp-19065	35	14	.	.	PROPN
bjp-19065	35	15	,	,	PUNCT
bjp-19065	35	16	2009	2009	NUM
bjp-19065	35	17	)	)	PUNCT
bjp-19065	35	18	.	.	PUNCT
bjp-19065	36	1	the	the	DET
bjp-19065	36	2	software	software	NOUN
bjp-19065	36	3	was	be	AUX
bjp-19065	36	4	used	use	VERB
bjp-19065	36	5	to	to	PART
bjp-19065	36	6	find	find	VERB
bjp-19065	36	7	the	the	DET
bjp-19065	36	8	best	good	ADJ
bjp-19065	36	9	binding	bind	VERB
bjp-19065	36	10	mode	mode	NOUN
bjp-19065	36	11	using	use	VERB
bjp-19065	36	12	binding	bind	VERB
bjp-19065	36	13	free	free	ADJ
bjp-19065	36	14	energy	energy	NOUN
bjp-19065	36	15	evaluations	evaluation	NOUN
bjp-19065	36	16	and	and	CCONJ
bjp-19065	36	17	number	number	NOUN
bjp-19065	36	18	of	of	ADP
bjp-19065	36	19	physical	physical	ADJ
bjp-19065	36	20	interactions	interaction	NOUN
bjp-19065	36	21	.	.	PUNCT
bjp-19065	37	1	autodock	autodock	NOUN
bjp-19065	37	2	calculates	calculate	VERB
bjp-19065	37	3	the	the	DET
bjp-19065	37	4	energy	energy	NOUN
bjp-19065	37	5	values	value	NOUN
bjp-19065	37	6	by	by	ADP
bjp-19065	37	7	the	the	DET
bjp-19065	37	8	characterization	characterization	NOUN
bjp-19065	37	9	of	of	ADP
bjp-19065	37	10	internal	internal	ADJ
bjp-19065	37	11	energy	energy	NOUN
bjp-19065	37	12	of	of	ADP
bjp-19065	37	13	ligand	ligand	NOUN
bjp-19065	37	14	,	,	PUNCT
bjp-19065	37	15	torsional	torsional	ADJ
bjp-19065	37	16	free	free	ADJ
bjp-19065	37	17	energy	energy	NOUN
bjp-19065	37	18	and	and	CCONJ
bjp-19065	37	19	intermolecular	intermolecular	ADJ
bjp-19065	37	20	energy	energy	NOUN
bjp-19065	37	21	consisting	consisting	NOUN
bjp-19065	37	22	of	of	ADP
bjp-19065	37	23	van	van	PROPN
bjp-19065	37	24	der	der	PROPN
bjp-19065	37	25	walls	wall	NOUN
bjp-19065	37	26	energy	energy	NOUN
bjp-19065	37	27	,	,	PUNCT
bjp-19065	37	28	hydrogen	hydrogen	NOUN
bjp-19065	37	29	bonding	bonding	NOUN
bjp-19065	37	30	energy	energy	NOUN
bjp-19065	37	31	,	,	PUNCT
bjp-19065	37	32	desolvation	desolvation	NOUN
bjp-19065	37	33	energy	energy	NOUN
bjp-19065	37	34	,	,	PUNCT
bjp-19065	37	35	and	and	CCONJ
bjp-19065	37	36	electrostatic	electrostatic	ADJ
bjp-19065	37	37	energy	energy	NOUN
bjp-19065	37	38	.	.	PUNCT
bjp-19065	38	1	372	372	NUM
bjp-19065	38	2	bangladesh	bangladesh	PROPN
bjp-19065	38	3	j	j	PROPN
bjp-19065	38	4	pharmacol	pharmacol	PROPN
bjp-19065	38	5	2014	2014	NUM
bjp-19065	38	6	;	;	PUNCT
bjp-19065	38	7	9	9	NUM
bjp-19065	38	8	:	:	SYM
bjp-19065	38	9	371	371	NUM
bjp-19065	38	10	-	-	SYM
bjp-19065	38	11	376	376	NUM
bjp-19065	38	12	figure	figure	NOUN
bjp-19065	38	13	1	1	NUM
bjp-19065	38	14	:	:	PUNCT
bjp-19065	38	15	step	step	VERB
bjp-19065	38	16	wise	wise	ADJ
bjp-19065	38	17	illustration	illustration	NOUN
bjp-19065	38	18	of	of	ADP
bjp-19065	38	19	the	the	DET
bjp-19065	38	20	modus	modus	ADJ
bjp-19065	38	21	operandi	operandi	NOUN
bjp-19065	38	22	in	in	ADP
bjp-19065	38	23	use	use	NOUN
bjp-19065	38	24	figure	figure	NOUN
bjp-19065	38	25	2	2	NUM
bjp-19065	38	26	:	:	PUNCT
bjp-19065	38	27	the	the	DET
bjp-19065	38	28	solid	solid	ADJ
bjp-19065	38	29	surface	surface	NOUN
bjp-19065	38	30	structure	structure	NOUN
bjp-19065	38	31	of	of	ADP
bjp-19065	38	32	il-6	il-6	NOUN
bjp-19065	38	33	with	with	ADP
bjp-19065	38	34	lead	lead	NOUN
bjp-19065	38	35	5	5	NUM
bjp-19065	38	36	binding	bind	VERB
bjp-19065	38	37	pocket	pocket	NOUN
bjp-19065	38	38	a	a	DET
bjp-19065	38	39	b	b	NOUN
bjp-19065	38	40	c	c	NOUN
bjp-19065	38	41	d	d	X
bjp-19065	38	42	e	e	PROPN
bjp-19065	38	43	result	result	NOUN
bjp-19065	38	44	and	and	CCONJ
bjp-19065	38	45	discussion	discussion	NOUN
bjp-19065	38	46	virtual	virtual	ADJ
bjp-19065	38	47	screening	screening	NOUN
bjp-19065	38	48	followed	follow	VERB
bjp-19065	38	49	by	by	ADP
bjp-19065	38	50	in	in	ADP
bjp-19065	38	51	silico	silico	NOUN
bjp-19065	38	52	adme	adme	NOUN
bjp-19065	38	53	/	/	SYM
bjp-19065	38	54	tox	tox	NOUN
bjp-19065	38	55	analysis	analysis	NOUN
bjp-19065	38	56	of	of	ADP
bjp-19065	38	57	il-6	il-6	NUM
bjp-19065	38	58	and	and	CCONJ
bjp-19065	38	59	ibs	ibs	PROPN
bjp-19065	38	60	database	database	NOUN
bjp-19065	38	61	was	be	AUX
bjp-19065	38	62	successful	successful	ADJ
bjp-19065	38	63	in	in	ADP
bjp-19065	38	64	limit	limit	NOUN
bjp-19065	38	65	-ing	-e	VERB
bjp-19065	38	66	our	our	PRON
bjp-19065	38	67	search	search	NOUN
bjp-19065	38	68	to	to	PART
bjp-19065	38	69	top	top	VERB
bjp-19065	38	70	50	50	NUM
bjp-19065	38	71	compounds	compound	NOUN
bjp-19065	38	72	.	.	PUNCT
bjp-19065	39	1	from	from	ADP
bjp-19065	39	2	the	the	DET
bjp-19065	39	3	initial	initial	ADJ
bjp-19065	39	4	data	datum	NOUN
bjp-19065	39	5	set	set	VERB
bjp-19065	39	6	of	of	ADP
bjp-19065	39	7	around	around	ADV
bjp-19065	39	8	fifty	fifty	NUM
bjp-19065	39	9	thousand	thousand	NUM
bjp-19065	39	10	natural	natural	ADJ
bjp-19065	39	11	products	product	NOUN
bjp-19065	39	12	selected	select	VERB
bjp-19065	39	13	for	for	ADP
bjp-19065	39	14	the	the	DET
bjp-19065	39	15	study	study	NOUN
bjp-19065	39	16	,	,	PUNCT
bjp-19065	39	17	subsets	subset	NOUN
bjp-19065	39	18	of	of	ADP
bjp-19065	39	19	five	five	NUM
bjp-19065	39	20	hundred	hundred	NUM
bjp-19065	39	21	lead	lead	ADJ
bjp-19065	39	22	-	-	PUNCT
bjp-19065	39	23	like	like	ADJ
bjp-19065	39	24	natural	natural	ADJ
bjp-19065	39	25	products	product	NOUN
bjp-19065	39	26	were	be	AUX
bjp-19065	39	27	selected	select	VERB
bjp-19065	39	28	using	use	VERB
bjp-19065	39	29	arguslab	arguslab	PROPN
bjp-19065	39	30	based	base	VERB
bjp-19065	39	31	on	on	ADP
bjp-19065	39	32	the	the	DET
bjp-19065	39	33	feature	feature	NOUN
bjp-19065	39	34	of	of	ADP
bjp-19065	39	35	binding	bind	VERB
bjp-19065	39	36	energy	energy	NOUN
bjp-19065	39	37	.	.	PUNCT
bjp-19065	40	1	the	the	DET
bjp-19065	40	2	vs	vs	ADV
bjp-19065	40	3	was	be	AUX
bjp-19065	40	4	followed	follow	VERB
bjp-19065	40	5	by	by	ADP
bjp-19065	40	6	adme	adme	NOUN
bjp-19065	40	7	/	/	SYM
bjp-19065	40	8	tox	tox	NOUN
bjp-19065	40	9	analysis	analysis	NOUN
bjp-19065	40	10	using	use	VERB
bjp-19065	40	11	lazar	lazar	PROPN
bjp-19065	40	12	toxicity	toxicity	NOUN
bjp-19065	40	13	predictions	prediction	NOUN
bjp-19065	40	14	online	online	ADJ
bjp-19065	40	15	server	server	NOUN
bjp-19065	40	16	to	to	PART
bjp-19065	40	17	further	far	ADV
bjp-19065	40	18	limit	limit	VERB
bjp-19065	40	19	the	the	DET
bjp-19065	40	20	size	size	NOUN
bjp-19065	40	21	of	of	ADP
bjp-19065	40	22	initial	initial	ADJ
bjp-19065	40	23	data	datum	NOUN
bjp-19065	40	24	-set	-set	ADJ
bjp-19065	40	25	.	.	PUNCT
bjp-19065	41	1	the	the	DET
bjp-19065	41	2	tool	tool	NOUN
bjp-19065	41	3	was	be	AUX
bjp-19065	41	4	pivotal	pivotal	ADJ
bjp-19065	41	5	in	in	ADP
bjp-19065	41	6	checking	check	VERB
bjp-19065	41	7	their	their	PRON
bjp-19065	41	8	mutagenic	mutagenic	ADJ
bjp-19065	41	9	and	and	CCONJ
bjp-19065	41	10	carcinogenic	carcinogenic	ADJ
bjp-19065	41	11	property	property	NOUN
bjp-19065	41	12	,	,	PUNCT
bjp-19065	41	13	the	the	DET
bjp-19065	41	14	shortlisted	shortlist	VERB
bjp-19065	41	15	fifty	fifty	NUM
bjp-19065	41	16	compound	compound	NOUN
bjp-19065	41	17	were	be	AUX
bjp-19065	41	18	selected	select	VERB
bjp-19065	41	19	on	on	ADP
bjp-19065	41	20	their	their	PRON
bjp-19065	41	21	drug	drug	NOUN
bjp-19065	41	22	likeness	likeness	NOUN
bjp-19065	41	23	(	(	PUNCT
bjp-19065	41	24	lipinski	lipinski	PROPN
bjp-19065	41	25	et	et	PROPN
bjp-19065	41	26	al	al	PROPN
bjp-19065	41	27	.	.	PROPN
bjp-19065	41	28	,	,	PUNCT
bjp-19065	41	29	2012	2012	NUM
bjp-19065	41	30	)	)	PUNCT
bjp-19065	41	31	and	and	CCONJ
bjp-19065	41	32	their	their	PRON
bjp-19065	41	33	observance	observance	NOUN
bjp-19065	41	34	of	of	ADP
bjp-19065	41	35	adme	adme	NOUN
bjp-19065	41	36	and	and	CCONJ
bjp-19065	41	37	related	related	ADJ
bjp-19065	41	38	properties	property	NOUN
bjp-19065	41	39	of	of	ADP
bjp-19065	41	40	typical	typical	ADJ
bjp-19065	41	41	drugs	drug	NOUN
bjp-19065	41	42	(	(	PUNCT
bjp-19065	41	43	zhao	zhao	X
bjp-19065	41	44	et	et	PROPN
bjp-19065	41	45	al	al	PROPN
bjp-19065	41	46	.	.	PROPN
bjp-19065	41	47	,	,	PUNCT
bjp-19065	41	48	2001	2001	NUM
bjp-19065	41	49	,	,	PUNCT
bjp-19065	41	50	van	van	PROPN
bjp-19065	41	51	de	de	PROPN
bjp-19065	41	52	waterbeemd	waterbeemd	PROPN
bjp-19065	41	53	et	et	PROPN
bjp-19065	41	54	al	al	PROPN
bjp-19065	41	55	.	.	PROPN
bjp-19065	41	56	,	,	PUNCT
bjp-19065	41	57	1998	1998	NUM
bjp-19065	41	58	)	)	PUNCT
bjp-19065	41	59	.	.	PUNCT
bjp-19065	42	1	for	for	ADP
bjp-19065	42	2	drug	drug	NOUN
bjp-19065	42	3	likeness	likeness	NOUN
bjp-19065	42	4	molecular	molecular	ADJ
bjp-19065	42	5	weight	weight	NOUN
bjp-19065	42	6	(	(	PUNCT
bjp-19065	42	7	mw	mw	NOUN
bjp-19065	42	8	)	)	PUNCT
bjp-19065	42	9	,	,	PUNCT
bjp-19065	42	10	number	number	NOUN
bjp-19065	42	11	of	of	ADP
bjp-19065	42	12	hydrogen	hydrogen	NOUN
bjp-19065	42	13	bond	bond	NOUN
bjp-19065	42	14	donor	donor	NOUN
bjp-19065	42	15	(	(	PUNCT
bjp-19065	42	16	hbd	hbd	NOUN
bjp-19065	42	17	)	)	PUNCT
bjp-19065	42	18	,	,	PUNCT
bjp-19065	42	19	number	number	NOUN
bjp-19065	42	20	of	of	ADP
bjp-19065	42	21	hydrogen	hydrogen	NOUN
bjp-19065	42	22	bond	bond	NOUN
bjp-19065	42	23	acceptor	acceptor	NOUN
bjp-19065	42	24	(	(	PUNCT
bjp-19065	42	25	hba	hba	NOUN
bjp-19065	42	26	)	)	PUNCT
bjp-19065	42	27	and	and	CCONJ
bjp-19065	42	28	total	total	ADJ
bjp-19065	42	29	polar	polar	ADJ
bjp-19065	42	30	surface	surface	NOUN
bjp-19065	42	31	area	area	NOUN
bjp-19065	42	32	(	(	PUNCT
bjp-19065	42	33	tpsa	tpsa	PROPN
bjp-19065	42	34	)	)	PUNCT
bjp-19065	42	35	,	,	PUNCT
bjp-19065	42	36	which	which	PRON
bjp-19065	42	37	all	all	DET
bjp-19065	42	38	fall	fall	VERB
bjp-19065	42	39	under	under	ADP
bjp-19065	42	40	lipinski	lipinski	PROPN
bjp-19065	42	41	’s	’s	PART
bjp-19065	42	42	rule	rule	NOUN
bjp-19065	42	43	of	of	ADP
bjp-19065	42	44	five	five	NUM
bjp-19065	42	45	(	(	PUNCT
bjp-19065	42	46	ro5	ro5	NOUN
bjp-19065	42	47	)	)	PUNCT
bjp-19065	42	48	were	be	AUX
bjp-19065	42	49	calculated	calculate	VERB
bjp-19065	42	50	.	.	PUNCT
bjp-19065	43	1	table	table	NOUN
bjp-19065	43	2	i	i	PRON
bjp-19065	43	3	shows	show	VERB
bjp-19065	43	4	the	the	DET
bjp-19065	43	5	ro5	ro5	ADJ
bjp-19065	43	6	data	datum	NOUN
bjp-19065	43	7	of	of	ADP
bjp-19065	43	8	top	top	ADJ
bjp-19065	43	9	five	five	NUM
bjp-19065	43	10	compounds	compound	NOUN
bjp-19065	43	11	.	.	PUNCT
bjp-19065	44	1	these	these	DET
bjp-19065	44	2	properties	property	NOUN
bjp-19065	44	3	have	have	VERB
bjp-19065	44	4	an	an	DET
bjp-19065	44	5	important	important	ADJ
bjp-19065	44	6	role	role	NOUN
bjp-19065	44	7	in	in	ADP
bjp-19065	44	8	the	the	DET
bjp-19065	44	9	final	final	ADJ
bjp-19065	44	10	outcome	outcome	NOUN
bjp-19065	44	11	and	and	CCONJ
bjp-19065	44	12	analyzing	analyze	VERB
bjp-19065	44	13	them	they	PRON
bjp-19065	44	14	using	use	VERB
bjp-19065	44	15	by	by	ADP
bjp-19065	44	16	in	in	ADP
bjp-19065	44	17	silico	silico	NOUN
bjp-19065	44	18	means	mean	VERB
bjp-19065	44	19	not	not	PART
bjp-19065	44	20	only	only	ADV
bjp-19065	44	21	saves	save	VERB
bjp-19065	44	22	time	time	NOUN
bjp-19065	44	23	but	but	CCONJ
bjp-19065	44	24	also	also	ADV
bjp-19065	44	25	is	be	AUX
bjp-19065	44	26	economically	economically	ADV
bjp-19065	44	27	more	more	ADV
bjp-19065	44	28	viable	viable	ADJ
bjp-19065	44	29	.	.	PUNCT
bjp-19065	45	1	the	the	DET
bjp-19065	45	2	permissible	permissible	ADJ
bjp-19065	45	3	range	range	NOUN
bjp-19065	45	4	of	of	ADP
bjp-19065	45	5	ro5	ro5	ADJ
bjp-19065	45	6	are	be	AUX
bjp-19065	45	7	mw≤500	mw≤500	PROPN
bjp-19065	45	8	dalton	dalton	PROPN
bjp-19065	45	9	,	,	PUNCT
bjp-19065	45	10	clog	clog	VERB
bjp-19065	45	11	p≤4.5	p≤4.5	NOUN
bjp-19065	45	12	,	,	PUNCT
bjp-19065	45	13	hbd	hbd	PROPN
bjp-19065	45	14	≤5	≤5	PROPN
bjp-19065	45	15	,	,	PUNCT
bjp-19065	45	16	hba	hba	PROPN
bjp-19065	45	17	≤10	≤10	PROPN
bjp-19065	45	18	,	,	PUNCT
bjp-19065	45	19	which	which	PRON
bjp-19065	45	20	is	be	AUX
bjp-19065	45	21	associated	associate	VERB
bjp-19065	45	22	with	with	ADP
bjp-19065	45	23	90	90	NUM
bjp-19065	45	24	%	%	NOUN
bjp-19065	45	25	of	of	ADP
bjp-19065	45	26	orally	orally	ADV
bjp-19065	45	27	active	active	ADJ
bjp-19065	45	28	drugs	drug	NOUN
bjp-19065	45	29	that	that	PRON
bjp-19065	45	30	have	have	AUX
bjp-19065	45	31	achieved	achieve	VERB
bjp-19065	45	32	phase	phase	NOUN
bjp-19065	45	33	ii	ii	NOUN
bjp-19065	45	34	clinical	clinical	ADJ
bjp-19065	45	35	status	status	NOUN
bjp-19065	45	36	(	(	PUNCT
bjp-19065	45	37	lipinski	lipinski	PROPN
bjp-19065	45	38	,	,	PUNCT
bjp-19065	45	39	2004	2004	NUM
bjp-19065	45	40	)	)	PUNCT
bjp-19065	45	41	.	.	PUNCT
bjp-19065	46	1	our	our	PRON
bjp-19065	46	2	lead	lead	NOUN
bjp-19065	46	3	compounds	compound	NOUN
bjp-19065	46	4	are	be	AUX
bjp-19065	46	5	in	in	ADP
bjp-19065	46	6	compliance	compliance	NOUN
bjp-19065	46	7	with	with	ADP
bjp-19065	46	8	the	the	DET
bjp-19065	46	9	ro5	ro5	ADJ
bjp-19065	46	10	properties	property	NOUN
bjp-19065	46	11	se	se	X
bjp-19065	46	12	by	by	ADP
bjp-19065	46	13	lipinski	lipinski	PROPN
bjp-19065	46	14	.	.	PUNCT
bjp-19065	47	1	the	the	DET
bjp-19065	47	2	initial	initial	ADJ
bjp-19065	47	3	database	database	NOUN
bjp-19065	47	4	contained	contain	VERB
bjp-19065	47	5	48,531	48,531	NUM
bjp-19065	47	6	natural	natural	ADJ
bjp-19065	47	7	products	product	NOUN
bjp-19065	47	8	selected	select	VERB
bjp-19065	47	9	for	for	ADP
bjp-19065	47	10	the	the	DET
bjp-19065	47	11	virtual	virtual	ADJ
bjp-19065	47	12	screening	screening	NOUN
bjp-19065	47	13	was	be	AUX
bjp-19065	47	14	condensed	condense	VERB
bjp-19065	47	15	based	base	VERB
bjp-19065	47	16	on	on	ADP
bjp-19065	47	17	binding	bind	VERB
bjp-19065	47	18	free	free	ADJ
bjp-19065	47	19	energy	energy	NOUN
bjp-19065	47	20	obtained	obtain	VERB
bjp-19065	47	21	by	by	ADP
bjp-19065	47	22	arguslab	arguslab	PROPN
bjp-19065	47	23	,	,	PUNCT
bjp-19065	47	24	the	the	DET
bjp-19065	47	25	initial	initial	ADJ
bjp-19065	47	26	dataset	dataset	NOUN
bjp-19065	47	27	was	be	AUX
bjp-19065	47	28	shortened	shorten	VERB
bjp-19065	47	29	almost	almost	ADV
bjp-19065	47	30	99	99	NUM
bjp-19065	47	31	%	%	NOUN
bjp-19065	47	32	of	of	ADP
bjp-19065	47	33	the	the	DET
bjp-19065	47	34	initial	initial	ADJ
bjp-19065	47	35	size	size	NOUN
bjp-19065	47	36	to	to	ADP
bjp-19065	47	37	mere	mere	ADJ
bjp-19065	47	38	five	five	NUM
bjp-19065	47	39	hundred	hundred	NUM
bjp-19065	47	40	compounds	compound	NOUN
bjp-19065	47	41	.	.	PUNCT
bjp-19065	48	1	further	far	ADV
bjp-19065	48	2	screening	screen	VERB
bjp-19065	48	3	ensured	ensure	VERB
bjp-19065	48	4	that	that	SCONJ
bjp-19065	48	5	only	only	ADV
bjp-19065	48	6	0.1	0.1	NUM
bjp-19065	48	7	%	%	NOUN
bjp-19065	48	8	of	of	ADP
bjp-19065	48	9	total	total	ADJ
bjp-19065	48	10	compounds	compound	NOUN
bjp-19065	48	11	i.e.	i.e.	X
bjp-19065	48	12	fifty	fifty	NUM
bjp-19065	48	13	compounds	compound	NOUN
bjp-19065	48	14	of	of	ADP
bjp-19065	48	15	natural	natural	ADJ
bjp-19065	48	16	origin	origin	NOUN
bjp-19065	48	17	were	be	AUX
bjp-19065	48	18	available	available	ADJ
bjp-19065	48	19	for	for	ADP
bjp-19065	48	20	further	far	ADV
bjp-19065	48	21	in	in	ADP
bjp-19065	48	22	silico	silico	NOUN
bjp-19065	48	23	studies	study	NOUN
bjp-19065	48	24	using	use	VERB
bjp-19065	48	25	autodock	autodock	NOUN
bjp-19065	48	26	4.2	4.2	NUM
bjp-19065	48	27	tool	tool	NOUN
bjp-19065	48	28	.	.	PUNCT
bjp-19065	49	1	the	the	DET
bjp-19065	49	2	proposed	propose	VERB
bjp-19065	49	3	target	target	NOUN
bjp-19065	49	4	site	site	NOUN
bjp-19065	49	5	was	be	AUX
bjp-19065	49	6	optimized	optimize	VERB
bjp-19065	49	7	for	for	ADP
bjp-19065	49	8	performing	perform	VERB
bjp-19065	49	9	the	the	DET
bjp-19065	49	10	docking	docking	NOUN
bjp-19065	49	11	studies	study	NOUN
bjp-19065	49	12	.	.	PUNCT
bjp-19065	50	1	among	among	ADP
bjp-19065	50	2	the	the	DET
bjp-19065	50	3	top	top	ADJ
bjp-19065	50	4	50	50	NUM
bjp-19065	50	5	compounds	compound	NOUN
bjp-19065	50	6	only	only	ADV
bjp-19065	50	7	5	5	NUM
bjp-19065	50	8	compounds	compound	NOUN
bjp-19065	50	9	were	be	AUX
bjp-19065	50	10	found	find	VERB
bjp-19065	50	11	to	to	PART
bjp-19065	50	12	physically	physically	ADV
bjp-19065	50	13	interact	interact	VERB
bjp-19065	50	14	with	with	ADP
bjp-19065	50	15	arg179	arg179	PROPN
bjp-19065	50	16	.	.	PUNCT
bjp-19065	51	1	the	the	DET
bjp-19065	51	2	final	final	ADJ
bjp-19065	51	3	shortlisted	shortlist	VERB
bjp-19065	51	4	natural	natural	ADJ
bjp-19065	51	5	compounds	compound	NOUN
bjp-19065	51	6	obtained	obtain	VERB
bjp-19065	51	7	by	by	ADP
bjp-19065	51	8	using	use	VERB
bjp-19065	51	9	autodock	autodock	NOUN
bjp-19065	51	10	4.2	4.2	NUM
bjp-19065	51	11	tool	tool	NOUN
bjp-19065	51	12	into	into	ADP
bjp-19065	51	13	the	the	DET
bjp-19065	51	14	optimized	optimize	VERB
bjp-19065	51	15	target	target	NOUN
bjp-19065	51	16	site	site	NOUN
bjp-19065	51	17	(	(	PUNCT
bjp-19065	51	18	figure	figure	NOUN
bjp-19065	51	19	2	2	NUM
bjp-19065	51	20	)	)	PUNCT
bjp-19065	51	21	of	of	ADP
bjp-19065	51	22	the	the	DET
bjp-19065	51	23	protein	protein	NOUN
bjp-19065	51	24	were	be	AUX
bjp-19065	51	25	analyzed	analyze	VERB
bjp-19065	51	26	for	for	ADP
bjp-19065	51	27	interaction	interaction	NOUN
bjp-19065	51	28	using	use	VERB
bjp-19065	51	29	discovery	discovery	PROPN
bjp-19065	51	30	studio	studio	NOUN
bjp-19065	51	31	3.5	3.5	NUM
bjp-19065	51	32	client	client	NOUN
bjp-19065	51	33	software	software	NOUN
bjp-19065	51	34	,	,	PUNCT
bjp-19065	51	35	the	the	DET
bjp-19065	51	36	interactions	interaction	NOUN
bjp-19065	51	37	are	be	AUX
bjp-19065	51	38	described	describe	VERB
bjp-19065	51	39	in	in	ADP
bjp-19065	51	40	table	table	NOUN
bjp-19065	51	41	ii	ii	PROPN
bjp-19065	51	42	.	.	PUNCT
bjp-19065	52	1	all	all	DET
bjp-19065	52	2	five	five	NUM
bjp-19065	52	3	lead	lead	NOUN
bjp-19065	52	4	compounds	compound	NOUN
bjp-19065	52	5	were	be	AUX
bjp-19065	52	6	found	find	VERB
bjp-19065	52	7	to	to	PART
bjp-19065	52	8	form	form	VERB
bjp-19065	52	9	hydrogen	hydrogen	NOUN
bjp-19065	52	10	bond	bond	NOUN
bjp-19065	52	11	with	with	ADP
bjp-19065	52	12	arg179	arg179	PROPN
bjp-19065	52	13	.	.	PUNCT
bjp-19065	53	1	the	the	DET
bjp-19065	53	2	interactions	interaction	NOUN
bjp-19065	53	3	(	(	PUNCT
bjp-19065	53	4	covalent	covalent	NOUN
bjp-19065	53	5	or	or	CCONJ
bjp-19065	53	6	non	non	ADJ
bjp-19065	53	7	covalent	covalent	NOUN
bjp-19065	53	8	)	)	PUNCT
bjp-19065	53	9	,	,	PUNCT
bjp-19065	53	10	the	the	DET
bjp-19065	53	11	number	number	NOUN
bjp-19065	53	12	of	of	ADP
bjp-19065	53	13	hydrogen	hydrogen	NOUN
bjp-19065	53	14	bonds	bond	NOUN
bjp-19065	53	15	and	and	CCONJ
bjp-19065	53	16	number	number	NOUN
bjp-19065	53	17	of	of	ADP
bjp-19065	53	18	pі	pі	ADJ
bjp-19065	53	19	-	-	PUNCT
bjp-19065	53	20	pi	pi	NOUN
bjp-19065	53	21	interactions	interaction	NOUN
bjp-19065	53	22	has	have	AUX
bjp-19065	53	23	been	be	AUX
bjp-19065	53	24	displayed	display	VERB
bjp-19065	53	25	in	in	ADP
bjp-19065	53	26	figure	figure	NOUN
bjp-19065	53	27	3	3	NUM
bjp-19065	53	28	for	for	ADP
bjp-19065	53	29	all	all	DET
bjp-19065	53	30	the	the	DET
bjp-19065	53	31	selected	select	VERB
bjp-19065	53	32	lead	lead	NOUN
bjp-19065	53	33	compounds	compound	NOUN
bjp-19065	53	34	.	.	PUNCT
bjp-19065	54	1	the	the	DET
bjp-19065	54	2	first	first	ADJ
bjp-19065	54	3	lead	lead	NOUN
bjp-19065	54	4	compound	compound	NOUN
bjp-19065	54	5	is	be	AUX
bjp-19065	54	6	famous	famous	ADJ
bjp-19065	54	7	as	as	ADP
bjp-19065	54	8	margaric	margaric	ADJ
bjp-19065	54	9	acid	acid	PROPN
bjp-19065	54	10	bangladesh	bangladesh	PROPN
bjp-19065	54	11	j	j	PROPN
bjp-19065	54	12	pharmacol	pharmacol	PROPN
bjp-19065	54	13	2014	2014	NUM
bjp-19065	54	14	;	;	PUNCT
bjp-19065	54	15	9	9	NUM
bjp-19065	54	16	:	:	SYM
bjp-19065	54	17	371	371	NUM
bjp-19065	54	18	-	-	SYM
bjp-19065	54	19	376	376	NUM
bjp-19065	54	20	373	373	NUM
bjp-19065	54	21	table	table	NOUN
bjp-19065	54	22	i	i	PRON
bjp-19065	54	23	lipinski	lipinski	PROPN
bjp-19065	54	24	rule	rule	NOUN
bjp-19065	54	25	of	of	ADP
bjp-19065	54	26	five	five	NUM
bjp-19065	54	27	and	and	CCONJ
bjp-19065	54	28	toxicolgy	toxicolgy	ADJ
bjp-19065	54	29	report	report	NOUN
bjp-19065	54	30	name	name	NOUN
bjp-19065	54	31	chemid	chemid	ADJ
bjp-19065	54	32	mw	mw	PROPN
bjp-19065	54	33	(	(	PUNCT
bjp-19065	54	34	dalton	dalton	PROPN
bjp-19065	54	35	)	)	PUNCT
bjp-19065	54	36	clogp	clogp	PROPN
bjp-19065	54	37	hbd	hbd	PROPN
bjp-19065	54	38	hba	hba	PROPN
bjp-19065	54	39	mutagenicity	mutagenicity	PROPN
bjp-19065	54	40	carcinogenecity	carcinogenecity	NOUN
bjp-19065	54	41	lead	lead	VERB
bjp-19065	54	42	1	1	NUM
bjp-19065	54	43	10465	10465	NUM
bjp-19065	54	44	270.5	270.5	NUM
bjp-19065	54	45	4.7	4.7	NUM
bjp-19065	54	46	1	1	NUM
bjp-19065	54	47	2	2	NUM
bjp-19065	54	48	no	no	INTJ
bjp-19065	54	49	no	no	DET
bjp-19065	54	50	lead	lead	NOUN
bjp-19065	54	51	2	2	NUM
bjp-19065	54	52	not	not	PART
bjp-19065	54	53	found	find	VERB
bjp-19065	54	54	313.3	313.3	NUM
bjp-19065	54	55	1.9	1.9	NUM
bjp-19065	54	56	3	3	NUM
bjp-19065	54	57	6	6	NUM
bjp-19065	54	58	no	no	INTJ
bjp-19065	54	59	no	no	DET
bjp-19065	54	60	lead	lead	NOUN
bjp-19065	54	61	3	3	NUM
bjp-19065	54	62	10518237	10518237	NUM
bjp-19065	54	63	299.3	299.3	NUM
bjp-19065	54	64	2.8	2.8	NUM
bjp-19065	54	65	5	5	NUM
bjp-19065	54	66	6	6	NUM
bjp-19065	54	67	no	no	INTJ
bjp-19065	54	68	no	no	DET
bjp-19065	54	69	lead	lead	NOUN
bjp-19065	54	70	4	4	NUM
bjp-19065	54	71	not	not	PART
bjp-19065	54	72	found	find	VERB
bjp-19065	54	73	423.5	423.5	NUM
bjp-19065	54	74	3.1	3.1	NUM
bjp-19065	54	75	1	1	NUM
bjp-19065	54	76	7	7	NUM
bjp-19065	54	77	no	no	INTJ
bjp-19065	54	78	no	no	DET
bjp-19065	54	79	lead	lead	NOUN
bjp-19065	54	80	5	5	NUM
bjp-19065	54	81	not	not	PART
bjp-19065	54	82	found	find	VERB
bjp-19065	54	83	340.4	340.4	NUM
bjp-19065	54	84	2.0	2.0	NUM
bjp-19065	54	85	3	3	NUM
bjp-19065	54	86	6	6	NUM
bjp-19065	54	87	no	no	PRON
bjp-19065	54	88	no	no	DET
bjp-19065	54	89	table	table	NOUN
bjp-19065	54	90	ii	ii	NOUN
bjp-19065	54	91	autodock	autodock	NOUN
bjp-19065	54	92	analysis	analysis	NOUN
bjp-19065	54	93	of	of	ADP
bjp-19065	54	94	five	five	NUM
bjp-19065	54	95	lead	lead	ADJ
bjp-19065	54	96	natural	natural	ADJ
bjp-19065	54	97	products	product	NOUN
bjp-19065	54	98	name	name	NOUN
bjp-19065	54	99	iupac	iupac	PROPN
bjp-19065	54	100	name	name	NOUN
bjp-19065	54	101	δg	δg	ADP
bjp-19065	54	102	kcal	kcal	PROPN
bjp-19065	54	103	/	/	SYM
bjp-19065	54	104	mol	mol	ADP
bjp-19065	54	105	ligand	ligand	NOUN
bjp-19065	54	106	binding	bind	VERB
bjp-19065	54	107	pocket	pocket	NOUN
bjp-19065	54	108	interactions	interaction	NOUN
bjp-19065	54	109	lead	lead	VERB
bjp-19065	54	110	1	1	NUM
bjp-19065	54	111	heptadecanoic	heptadecanoic	ADJ
bjp-19065	54	112	acid	acid	NOUN
bjp-19065	54	113	-1.5	-1.5	PUNCT
bjp-19065	54	114	gln175,leu178,arg179	gln175,leu178,arg179	NOUN
bjp-19065	54	115	,	,	PUNCT
bjp-19065	54	116	arg182	arg182	PROPN
bjp-19065	54	117	1	1	NUM
bjp-19065	54	118	hydrogen	hydrogen	NOUN
bjp-19065	54	119	bond	bond	NOUN
bjp-19065	54	120	lead	lead	VERB
bjp-19065	54	121	2	2	NUM
bjp-19065	54	122	2-(2-((3	2-(2-((3	NUM
bjp-19065	54	123	-	-	PUNCT
bjp-19065	54	124	carboxybenzyl)amino)-2oxoethyl)benzoic	carboxybenzyl)amino)-2oxoethyl)benzoic	ADJ
bjp-19065	54	125	acid	acid	NOUN
bjp-19065	54	126	-5.4	-5.4	PROPN
bjp-19065	54	127	lys171	lys171	PROPN
bjp-19065	54	128	,	,	PUNCT
bjp-19065	54	129	gln175,arg179	gln175,arg179	NOUN
bjp-19065	54	130	,	,	PUNCT
bjp-19065	54	131	arg182	arg182	PROPN
bjp-19065	54	132	5	5	NUM
bjp-19065	54	133	hydrogen	hydrogen	NOUN
bjp-19065	54	134	bond	bond	NOUN
bjp-19065	54	135	2	2	NUM
bjp-19065	54	136	pi	pi	NOUN
bjp-19065	54	137	bonds	bond	NOUN
bjp-19065	54	138	lead	lead	VERB
bjp-19065	54	139	3	3	NUM
bjp-19065	54	140	2-(2-(2	2-(2-(2	NUM
bjp-19065	54	141	-	-	PUNCT
bjp-19065	54	142	carboxyphenyl)acetamido	carboxyphenyl)acetamido	NOUN
bjp-19065	54	143	)	)	PUNCT
bjp-19065	54	144	benzoic	benzoic	ADJ
bjp-19065	54	145	acid	acid	NOUN
bjp-19065	54	146	-5.4	-5.4	PROPN
bjp-19065	54	147	gln175,leu178,arg179	gln175,leu178,arg179	PROPN
bjp-19065	54	148	,	,	PUNCT
bjp-19065	54	149	arg182	arg182	PROPN
bjp-19065	54	150	4	4	NUM
bjp-19065	54	151	hydrogen	hydrogen	NOUN
bjp-19065	54	152	bond	bond	NOUN
bjp-19065	54	153	lead	lead	NOUN
bjp-19065	54	154	4	4	NUM
bjp-19065	54	155	(	(	PUNCT
bjp-19065	54	156	s)-methyl	s)-methyl	NOUN
bjp-19065	54	157	2-(3-(7	2-(3-(7	NUM
bjp-19065	54	158	-	-	PUNCT
bjp-19065	54	159	methoxy-4	methoxy-4	NUM
bjp-19065	54	160	-	-	PUNCT
bjp-19065	54	161	methyl2	methyl2	NOUN
bjp-19065	54	162	-	-	PUNCT
bjp-19065	54	163	oxo-2h	oxo-2h	NOUN
bjp-19065	54	164	-	-	PUNCT
bjp-19065	54	165	chromen-6	chromen-6	NOUN
bjp-19065	54	166	-	-	PUNCT
bjp-19065	54	167	yl	yl	NOUN
bjp-19065	54	168	)	)	PUNCT
bjp-19065	54	169	propanamido)-3	propanamido)-3	PROPN
bjp-19065	54	170	-	-	PUNCT
bjp-19065	54	171	phenylpropanoate	phenylpropanoate	NOUN
bjp-19065	54	172	-3.9	-3.9	NOUN
bjp-19065	54	173	asp26	asp26	PROPN
bjp-19065	54	174	,	,	PUNCT
bjp-19065	54	175	arg30	arg30	PROPN
bjp-19065	54	176	,	,	PUNCT
bjp-19065	54	177	lys171	lys171	PROPN
bjp-19065	54	178	,	,	PUNCT
bjp-19065	54	179	gln175	gln175	PROPN
bjp-19065	54	180	,	,	PUNCT
bjp-19065	54	181	ser176	ser176	PROPN
bjp-19065	54	182	,	,	PUNCT
bjp-19065	54	183	leu178	leu178	PROPN
bjp-19065	54	184	,	,	PUNCT
bjp-19065	54	185	arg179	arg179	PROPN
bjp-19065	54	186	,	,	PUNCT
bjp-19065	54	187	arg182	arg182	PROPN
bjp-19065	54	188	2	2	NUM
bjp-19065	54	189	hydrogen	hydrogen	NOUN
bjp-19065	54	190	bond	bond	NOUN
bjp-19065	54	191	5	5	NUM
bjp-19065	54	192	pi	pi	NOUN
bjp-19065	54	193	bonds	bond	NOUN
bjp-19065	54	194	lead	lead	VERB
bjp-19065	54	195	5	5	NUM
bjp-19065	54	196	2-(2-((3-(isopropylcarbamoyl)phenyl	2-(2-((3-(isopropylcarbamoyl)phenyl	NUM
bjp-19065	54	197	)	)	PUNCT
bjp-19065	54	198	amino)-2	amino)-2	PROPN
bjp-19065	54	199	-	-	PUNCT
bjp-19065	54	200	oxoethyl)benzoic	oxoethyl)benzoic	ADJ
bjp-19065	54	201	acid	acid	NOUN
bjp-19065	54	202	-5.2	-5.2	PUNCT
bjp-19065	54	203	leu33	leu33	NOUN
bjp-19065	54	204	,	,	PUNCT
bjp-19065	54	205	cys73	cys73	PROPN
bjp-19065	54	206	,	,	PUNCT
bjp-19065	54	207	phe74	phe74	ADJ
bjp-19065	54	208	,	,	PUNCT
bjp-19065	54	209	gln75	gln75	INTJ
bjp-19065	54	210	,	,	PUNCT
bjp-19065	54	211	leu174	leu174	PROPN
bjp-19065	54	212	,	,	PUNCT
bjp-19065	54	213	gln175	gln175	PROPN
bjp-19065	54	214	,	,	PUNCT
bjp-19065	54	215	ser176	ser176	PROPN
bjp-19065	54	216	,	,	PUNCT
bjp-19065	54	217	leu178	leu178	PROPN
bjp-19065	54	218	,	,	PUNCT
bjp-19065	54	219	arg	arg	NOUN
bjp-19065	54	220	179	179	NUM
bjp-19065	54	221	,	,	PUNCT
bjp-19065	54	222	arg	arg	NOUN
bjp-19065	54	223	182	182	NUM
bjp-19065	54	224	.	.	SYM
bjp-19065	54	225	2	2	NUM
bjp-19065	54	226	hydrogen	hydrogen	NOUN
bjp-19065	54	227	bond	bond	NOUN
bjp-19065	54	228	1	1	NUM
bjp-19065	54	229	pi	pi	NOUN
bjp-19065	54	230	bonds	bond	NOUN
bjp-19065	54	231	the	the	DET
bjp-19065	54	232	ligand	ligand	ADJ
bjp-19065	54	233	binding	bind	VERB
bjp-19065	54	234	pocket	pocket	NOUN
bjp-19065	54	235	and	and	CCONJ
bjp-19065	54	236	the	the	DET
bjp-19065	54	237	hydrogen	hydrogen	NOUN
bjp-19065	54	238	bond	bond	NOUN
bjp-19065	54	239	formation	formation	NOUN
bjp-19065	54	240	was	be	AUX
bjp-19065	54	241	calculated	calculate	VERB
bjp-19065	54	242	using	use	VERB
bjp-19065	54	243	discovery	discovery	NOUN
bjp-19065	54	244	studio	studio	NOUN
bjp-19065	54	245	3.5	3.5	NUM
bjp-19065	54	246	software	software	NOUN
bjp-19065	54	247	.	.	PUNCT
bjp-19065	55	1	the	the	DET
bjp-19065	55	2	bold	bold	ADJ
bjp-19065	55	3	amino	amino	NOUN
bjp-19065	55	4	acids	acid	NOUN
bjp-19065	55	5	represent	represent	VERB
bjp-19065	55	6	the	the	DET
bjp-19065	55	7	one	one	NOUN
bjp-19065	55	8	which	which	PRON
bjp-19065	55	9	are	be	AUX
bjp-19065	55	10	involved	involve	VERB
bjp-19065	55	11	in	in	ADP
bjp-19065	55	12	forming	form	VERB
bjp-19065	55	13	interaction	interaction	NOUN
bjp-19065	55	14	with	with	ADP
bjp-19065	55	15	the	the	DET
bjp-19065	55	16	ligand	ligand	NOUN
bjp-19065	55	17	having	have	VERB
bjp-19065	55	18	pubchem	pubchem	NOUN
bjp-19065	55	19	i	i	PROPN
bjp-19065	55	20	d	d	PROPN
bjp-19065	55	21	10465	10465	NUM
bjp-19065	55	22	showed	show	VERB
bjp-19065	55	23	lowest	low	ADJ
bjp-19065	55	24	binding	bind	VERB
bjp-19065	55	25	energy	energy	NOUN
bjp-19065	55	26	of	of	ADP
bjp-19065	55	27	-1.5	-1.5	ADJ
bjp-19065	55	28	kcal	kcal	PROPN
bjp-19065	55	29	/	/	SYM
bjp-19065	55	30	mol	mol	PROPN
bjp-19065	55	31	.	.	PUNCT
bjp-19065	56	1	the	the	DET
bjp-19065	56	2	complex	complex	NOUN
bjp-19065	56	3	exhibited	exhibit	VERB
bjp-19065	56	4	a	a	DET
bjp-19065	56	5	lone	lone	ADJ
bjp-19065	56	6	hydrogen	hydrogen	NOUN
bjp-19065	56	7	bond	bond	NOUN
bjp-19065	56	8	(	(	PUNCT
bjp-19065	56	9	figure	figure	NOUN
bjp-19065	56	10	4a	4a	NUM
bjp-19065	56	11	)	)	PUNCT
bjp-19065	56	12	with	with	ADP
bjp-19065	56	13	the	the	DET
bjp-19065	56	14	key	key	ADJ
bjp-19065	56	15	residue	residue	NOUN
bjp-19065	56	16	arg179	arg179	NOUN
bjp-19065	56	17	of	of	ADP
bjp-19065	56	18	il-6.the	il-6.the	DET
bjp-19065	56	19	hydrogen	hydrogen	NOUN
bjp-19065	56	20	bond	bond	NOUN
bjp-19065	56	21	interaction	interaction	NOUN
bjp-19065	56	22	of	of	ADP
bjp-19065	56	23	2.72	2.72	NUM
bjp-19065	56	24	ǻ	ǻ	NOUN
bjp-19065	56	25	is	be	AUX
bjp-19065	56	26	between	between	ADP
bjp-19065	56	27	the	the	DET
bjp-19065	56	28	o2	o2	NOUN
bjp-19065	56	29	of	of	ADP
bjp-19065	56	30	the	the	DET
bjp-19065	56	31	lead	lead	NOUN
bjp-19065	56	32	1	1	NUM
bjp-19065	56	33	and	and	CCONJ
bjp-19065	56	34	n1	n1	ADJ
bjp-19065	56	35	atom	atom	NOUN
bjp-19065	56	36	of	of	ADP
bjp-19065	56	37	arg179	arg179	PROPN
bjp-19065	56	38	.	.	PUNCT
bjp-19065	57	1	the	the	DET
bjp-19065	57	2	binding	bind	VERB
bjp-19065	57	3	pocket	pocket	NOUN
bjp-19065	57	4	of	of	ADP
bjp-19065	57	5	this	this	DET
bjp-19065	57	6	complex	complex	ADJ
bjp-19065	57	7	constitutes	constitute	NOUN
bjp-19065	57	8	of	of	ADP
bjp-19065	57	9	gln175	gln175	PROPN
bjp-19065	57	10	,	,	PUNCT
bjp-19065	57	11	leu178	leu178	PROPN
bjp-19065	57	12	,	,	PUNCT
bjp-19065	57	13	arg179	arg179	PROPN
bjp-19065	57	14	and	and	CCONJ
bjp-19065	57	15	arg182	arg182	PROPN
bjp-19065	57	16	.	.	PUNCT
bjp-19065	58	1	the	the	DET
bjp-19065	58	2	second	second	ADJ
bjp-19065	58	3	lead	lead	NOUN
bjp-19065	58	4	interacting	interact	VERB
bjp-19065	58	5	with	with	ADP
bjp-19065	58	6	targeted	target	VERB
bjp-19065	58	7	site	site	NOUN
bjp-19065	58	8	of	of	ADP
bjp-19065	58	9	il-6	il-6	NOUN
bjp-19065	58	10	has	have	VERB
bjp-19065	58	11	ibs	ibs	PROPN
bjp-19065	58	12	i	i	PROPN
bjp-19065	58	13	d	d	PROPN
bjp-19065	58	14	:	:	PUNCT
bjp-19065	58	15	77198	77198	NUM
bjp-19065	58	16	.	.	PUNCT
bjp-19065	59	1	its	its	PRON
bjp-19065	59	2	binding	bind	VERB
bjp-19065	59	3	pocket	pocket	NOUN
bjp-19065	59	4	comprises	comprise	NOUN
bjp-19065	59	5	of	of	ADP
bjp-19065	59	6	lys171	lys171	PROPN
bjp-19065	59	7	,	,	PUNCT
bjp-19065	59	8	gln175	gln175	PROPN
bjp-19065	59	9	,	,	PUNCT
bjp-19065	59	10	arg179	arg179	PROPN
bjp-19065	59	11	and	and	CCONJ
bjp-19065	59	12	arg182	arg182	PROPN
bjp-19065	59	13	.	.	PUNCT
bjp-19065	60	1	the	the	DET
bjp-19065	60	2	complex	complex	NOUN
bjp-19065	60	3	of	of	ADP
bjp-19065	60	4	lead	lead	NOUN
bjp-19065	60	5	2	2	NUM
bjp-19065	60	6	and	and	CCONJ
bjp-19065	60	7	il-6	il-6	NOUN
bjp-19065	60	8	is	be	AUX
bjp-19065	60	9	the	the	DET
bjp-19065	60	10	most	most	ADV
bjp-19065	60	11	stable	stable	ADJ
bjp-19065	60	12	having	have	VERB
bjp-19065	60	13	δg	δg	PART
bjp-19065	60	14	of	of	ADP
bjp-19065	60	15	-5.4	-5.4	PROPN
bjp-19065	60	16	kcal	kcal	PROPN
bjp-19065	60	17	/	/	SYM
bjp-19065	60	18	mol	mol	NOUN
bjp-19065	60	19	with	with	ADP
bjp-19065	60	20	five	five	NUM
bjp-19065	60	21	hydrogen	hydrogen	NOUN
bjp-19065	60	22	bonds	bond	NOUN
bjp-19065	60	23	and	and	CCONJ
bjp-19065	60	24	two	two	NUM
bjp-19065	60	25	pі	pі	ADJ
bjp-19065	60	26	-	-	PUNCT
bjp-19065	60	27	pi	pi	NOUN
bjp-19065	60	28	interactions	interaction	NOUN
bjp-19065	60	29	.	.	PUNCT
bjp-19065	61	1	the	the	DET
bjp-19065	61	2	interaction	interaction	NOUN
bjp-19065	61	3	of	of	ADP
bjp-19065	61	4	our	our	PRON
bjp-19065	61	5	interest	interest	NOUN
bjp-19065	61	6	here	here	ADV
bjp-19065	61	7	is	be	AUX
bjp-19065	61	8	that	that	PRON
bjp-19065	61	9	of	of	ADP
bjp-19065	61	10	arg179	arg179	PROPN
bjp-19065	61	11	and	and	CCONJ
bjp-19065	61	12	ligands	ligand	NOUN
bjp-19065	61	13	o10	o10	NUM
bjp-19065	61	14	position	position	NOUN
bjp-19065	61	15	.	.	PUNCT
bjp-19065	62	1	the	the	DET
bjp-19065	62	2	distance	distance	NOUN
bjp-19065	62	3	between	between	ADP
bjp-19065	62	4	the	the	DET
bjp-19065	62	5	two	two	NUM
bjp-19065	62	6	is	be	AUX
bjp-19065	62	7	2.28	2.28	NUM
bjp-19065	62	8	ǻ	ǻ	NOUN
bjp-19065	62	9	.	.	PUNCT
bjp-19065	63	1	the	the	DET
bjp-19065	63	2	two	two	NUM
bjp-19065	63	3	pі	pі	ADJ
bjp-19065	63	4	-	-	PUNCT
bjp-19065	63	5	pi	pi	NOUN
bjp-19065	63	6	interactions	interaction	NOUN
bjp-19065	63	7	are	be	AUX
bjp-19065	63	8	with	with	ADP
bjp-19065	63	9	nh1	nh1	NOUN
bjp-19065	63	10	and	and	CCONJ
bjp-19065	63	11	nh2	nh2	PROPN
bjp-19065	63	12	of	of	ADP
bjp-19065	63	13	arg179	arg179	PROPN
bjp-19065	63	14	with	with	ADP
bjp-19065	63	15	a	a	DET
bjp-19065	63	16	distance	distance	NOUN
bjp-19065	63	17	of	of	ADP
bjp-19065	63	18	5.5	5.5	NUM
bjp-19065	63	19	ǻ	ǻ	NOUN
bjp-19065	63	20	and	and	CCONJ
bjp-19065	63	21	3.72	3.72	NUM
bjp-19065	63	22	ǻ	ǻ	PRON
bjp-19065	63	23	respectively	respectively	ADV
bjp-19065	63	24	,	,	PUNCT
bjp-19065	63	25	figure	figure	VERB
bjp-19065	63	26	4b	4b	PROPN
bjp-19065	63	27	shows	show	VERB
bjp-19065	63	28	the	the	DET
bjp-19065	63	29	mapping	mapping	NOUN
bjp-19065	63	30	of	of	ADP
bjp-19065	63	31	complex	complex	ADJ
bjp-19065	63	32	2	2	NUM
bjp-19065	63	33	.	.	PUNCT
bjp-19065	63	34	with	with	ADP
bjp-19065	63	35	a	a	DET
bjp-19065	63	36	δg	δg	NOUN
bjp-19065	63	37	of	of	ADP
bjp-19065	63	38	-5.4	-5.4	PROPN
bjp-19065	63	39	kcal	kcal	PROPN
bjp-19065	63	40	/	/	SYM
bjp-19065	63	41	mol	mol	PROPN
bjp-19065	63	42	,	,	PUNCT
bjp-19065	63	43	four	four	NUM
bjp-19065	63	44	hydrogen	hydrogen	NOUN
bjp-19065	63	45	bonds	bond	NOUN
bjp-19065	63	46	and	and	CCONJ
bjp-19065	63	47	no	no	DET
bjp-19065	63	48	pі	pі	ADJ
bjp-19065	63	49	-	-	PUNCT
bjp-19065	63	50	pi	pi	NOUN
bjp-19065	63	51	interaction	interaction	NOUN
bjp-19065	63	52	,	,	PUNCT
bjp-19065	63	53	lead	lead	VERB
bjp-19065	63	54	3	3	NUM
bjp-19065	63	55	is	be	AUX
bjp-19065	63	56	showing	show	VERB
bjp-19065	63	57	that	that	SCONJ
bjp-19065	63	58	the	the	DET
bjp-19065	63	59	compound	compound	NOUN
bjp-19065	63	60	is	be	AUX
bjp-19065	63	61	second	second	ADJ
bjp-19065	63	62	to	to	PART
bjp-19065	63	63	lead	lead	VERB
bjp-19065	63	64	2	2	NUM
bjp-19065	63	65	.	.	PUNCT
bjp-19065	63	66	from	from	ADP
bjp-19065	63	67	figure	figure	NOUN
bjp-19065	63	68	4c	4c	NOUN
bjp-19065	63	69	we	we	PRON
bjp-19065	63	70	can	can	AUX
bjp-19065	63	71	point	point	VERB
bjp-19065	63	72	out	out	ADP
bjp-19065	63	73	that	that	SCONJ
bjp-19065	63	74	out	out	ADP
bjp-19065	63	75	of	of	ADP
bjp-19065	63	76	the	the	DET
bjp-19065	63	77	four	four	NUM
bjp-19065	63	78	interactions	interaction	NOUN
bjp-19065	63	79	two	two	NUM
bjp-19065	63	80	are	be	AUX
bjp-19065	63	81	of	of	ADP
bjp-19065	63	82	our	our	PRON
bjp-19065	63	83	interest	interest	NOUN
bjp-19065	63	84	as	as	SCONJ
bjp-19065	63	85	they	they	PRON
bjp-19065	63	86	involve	involve	VERB
bjp-19065	63	87	arg179	arg179	PROPN
bjp-19065	63	88	.	.	PUNCT
bjp-19065	64	1	the	the	DET
bjp-19065	64	2	first	first	ADJ
bjp-19065	64	3	being	be	AUX
bjp-19065	64	4	between	between	ADP
bjp-19065	64	5	o11	o11	NOUN
bjp-19065	64	6	of	of	ADP
bjp-19065	64	7	the	the	DET
bjp-19065	64	8	lead	lead	NOUN
bjp-19065	64	9	3	3	NUM
bjp-19065	64	10	and	and	CCONJ
bjp-19065	64	11	ne	ne	PROPN
bjp-19065	64	12	of	of	ADP
bjp-19065	64	13	arg	arg	NOUN
bjp-19065	64	14	179	179	NUM
bjp-19065	64	15	having	have	VERB
bjp-19065	64	16	distance	distance	NOUN
bjp-19065	64	17	of	of	ADP
bjp-19065	64	18	2.88	2.88	NUM
bjp-19065	64	19	ǻ	ǻ	NOUN
bjp-19065	64	20	and	and	CCONJ
bjp-19065	64	21	the	the	DET
bjp-19065	64	22	second	second	ADJ
bjp-19065	64	23	interaction	interaction	NOUN
bjp-19065	64	24	of	of	ADP
bjp-19065	64	25	2.71	2.71	NUM
bjp-19065	64	26	ǻ	ǻ	NOUN
bjp-19065	64	27	is	be	AUX
bjp-19065	64	28	between	between	ADP
bjp-19065	64	29	o14	o14	NOUN
bjp-19065	64	30	of	of	ADP
bjp-19065	64	31	lead	lead	NOUN
bjp-19065	64	32	and	and	CCONJ
bjp-19065	64	33	nh	nh	PROPN
bjp-19065	64	34	of	of	ADP
bjp-19065	64	35	arg179	arg179	PROPN
bjp-19065	64	36	.	.	PUNCT
bjp-19065	65	1	the	the	DET
bjp-19065	65	2	binding	bind	VERB
bjp-19065	65	3	pocket	pocket	NOUN
bjp-19065	65	4	of	of	ADP
bjp-19065	65	5	lead	lead	ADJ
bjp-19065	65	6	3	3	NUM
bjp-19065	65	7	comprises	comprise	NOUN
bjp-19065	65	8	of	of	ADP
bjp-19065	65	9	gln175	gln175	PROPN
bjp-19065	65	10	,	,	PUNCT
bjp-19065	65	11	ley178	ley178	PROPN
bjp-19065	65	12	,	,	PUNCT
bjp-19065	65	13	arg179	arg179	PROPN
bjp-19065	65	14	and	and	CCONJ
bjp-19065	65	15	arg182	arg182	PROPN
bjp-19065	65	16	.	.	PUNCT
bjp-19065	66	1	the	the	DET
bjp-19065	66	2	complex	complex	NOUN
bjp-19065	66	3	between	between	ADP
bjp-19065	66	4	lead	lead	NOUN
bjp-19065	66	5	4	4	NUM
bjp-19065	66	6	and	and	CCONJ
bjp-19065	66	7	il-6	il-6	NOUN
bjp-19065	66	8	is	be	AUX
bjp-19065	66	9	rich	rich	ADJ
bjp-19065	66	10	in	in	ADP
bjp-19065	66	11	pі	pі	ADJ
bjp-19065	66	12	-	-	PUNCT
bjp-19065	66	13	pi	pi	NOUN
bjp-19065	66	14	interactions	interaction	NOUN
bjp-19065	66	15	(	(	PUNCT
bjp-19065	66	16	figure	figure	NOUN
bjp-19065	66	17	4d	4d	NUM
bjp-19065	66	18	)	)	PUNCT
bjp-19065	66	19	,	,	PUNCT
bjp-19065	66	20	four	four	NUM
bjp-19065	66	21	of	of	ADP
bjp-19065	66	22	the	the	DET
bjp-19065	66	23	six	six	NUM
bjp-19065	66	24	pі	pі	ADJ
bjp-19065	66	25	-	-	PUNCT
bjp-19065	66	26	pi	pi	NOUN
bjp-19065	66	27	interactions	interaction	NOUN
bjp-19065	66	28	is	be	AUX
bjp-19065	66	29	between	between	ADP
bjp-19065	66	30	the	the	DET
bjp-19065	66	31	lead	lead	NOUN
bjp-19065	66	32	4	4	NUM
bjp-19065	66	33	and	and	CCONJ
bjp-19065	66	34	arg179	arg179	PROPN
bjp-19065	66	35	with	with	ADP
bjp-19065	66	36	a	a	DET
bjp-19065	66	37	distance	distance	NOUN
bjp-19065	66	38	ranging	range	VERB
bjp-19065	66	39	from	from	ADP
bjp-19065	66	40	3	3	NUM
bjp-19065	66	41	ǻ	ǻ	NOUN
bjp-19065	66	42	to	to	ADP
bjp-19065	66	43	5	5	NUM
bjp-19065	66	44	ǻ	ǻ	NOUN
bjp-19065	66	45	.	.	PUNCT
bjp-19065	67	1	the	the	DET
bjp-19065	67	2	δg	δg	NOUN
bjp-19065	67	3	of	of	ADP
bjp-19065	67	4	-3.9	-3.9	NOUN
bjp-19065	67	5	kcal	kcal	NOUN
bjp-19065	67	6	/	/	SYM
bjp-19065	67	7	mol	mol	PROPN
bjp-19065	67	8	makes	make	VERB
bjp-19065	67	9	it	it	PRON
bjp-19065	67	10	the	the	DET
bjp-19065	67	11	forth	forth	ADV
bjp-19065	67	12	least	least	ADJ
bjp-19065	67	13	free	free	ADJ
bjp-19065	67	14	energy	energy	NOUN
bjp-19065	67	15	complex	complex	NOUN
bjp-19065	67	16	forming	form	VERB
bjp-19065	67	17	two	two	NUM
bjp-19065	67	18	hydrogen	hydrogen	NOUN
bjp-19065	67	19	bond	bond	NOUN
bjp-19065	67	20	interaction	interaction	NOUN
bjp-19065	67	21	,	,	PUNCT
bjp-19065	67	22	the	the	DET
bjp-19065	67	23	interaction	interaction	NOUN
bjp-19065	67	24	with	with	ADP
bjp-19065	67	25	arg179	arg179	PROPN
bjp-19065	67	26	is	be	AUX
bjp-19065	67	27	of	of	ADP
bjp-19065	67	28	3	3	NUM
bjp-19065	67	29	ǻ	ǻ	NOUN
bjp-19065	67	30	between	between	ADP
bjp-19065	67	31	o18	o18	ADJ
bjp-19065	67	32	of	of	ADP
bjp-19065	67	33	lead	lead	NOUN
bjp-19065	67	34	and	and	CCONJ
bjp-19065	67	35	ne	ne	NOUN
bjp-19065	67	36	of	of	ADP
bjp-19065	67	37	arg179	arg179	PROPN
bjp-19065	67	38	.	.	PUNCT
bjp-19065	68	1	the	the	DET
bjp-19065	68	2	binding	bind	VERB
bjp-19065	68	3	groove	groove	NOUN
bjp-19065	68	4	consists	consist	VERB
bjp-19065	68	5	of	of	ADP
bjp-19065	68	6	asp26	asp26	PROPN
bjp-19065	68	7	,	,	PUNCT
bjp-19065	68	8	arg30	arg30	PROPN
bjp-19065	68	9	,	,	PUNCT
bjp-19065	68	10	lys171	lys171	PROPN
bjp-19065	68	11	,	,	PUNCT
bjp-19065	68	12	gln175	gln175	PROPN
bjp-19065	68	13	,	,	PUNCT
bjp-19065	68	14	ser176	ser176	PROPN
bjp-19065	68	15	,	,	PUNCT
bjp-19065	68	16	leu178	leu178	PROPN
bjp-19065	68	17	,	,	PUNCT
bjp-19065	68	18	arg179	arg179	PROPN
bjp-19065	68	19	and	and	CCONJ
bjp-19065	68	20	arg182	arg182	PROPN
bjp-19065	68	21	.	.	PUNCT
bjp-19065	69	1	the	the	DET
bjp-19065	69	2	final	final	ADJ
bjp-19065	69	3	complex	complex	NOUN
bjp-19065	69	4	to	to	PART
bjp-19065	69	5	form	form	VERB
bjp-19065	69	6	an	an	DET
bjp-19065	69	7	interaction	interaction	NOUN
bjp-19065	69	8	with	with	ADP
bjp-19065	69	9	arg179	arg179	PROPN
bjp-19065	69	10	is	be	AUX
bjp-19065	69	11	lead	lead	ADJ
bjp-19065	69	12	5	5	NUM
bjp-19065	69	13	,	,	PUNCT
bjp-19065	69	14	with	with	ADP
bjp-19065	69	15	δg	δg	ADP
bjp-19065	69	16	of	of	ADP
bjp-19065	69	17	-5.2	-5.2	X
bjp-19065	69	18	kcal	kcal	PROPN
bjp-19065	69	19	/	/	SYM
bjp-19065	69	20	mol	mol	ADP
bjp-19065	69	21	the	the	DET
bjp-19065	69	22	complex	complex	NOUN
bjp-19065	69	23	is	be	AUX
bjp-19065	69	24	third	third	ADJ
bjp-19065	69	25	in	in	ADP
bjp-19065	69	26	line	line	NOUN
bjp-19065	69	27	in	in	ADP
bjp-19065	69	28	terms	term	NOUN
bjp-19065	69	29	of	of	ADP
bjp-19065	69	30	free	free	ADJ
bjp-19065	69	31	energy	energy	NOUN
bjp-19065	69	32	.	.	PUNCT
bjp-19065	70	1	the	the	DET
bjp-19065	70	2	complex	complex	NOUN
bjp-19065	70	3	is	be	AUX
bjp-19065	70	4	forming	form	VERB
bjp-19065	70	5	both	both	PRON
bjp-19065	70	6	hydrogen	hydrogen	NOUN
bjp-19065	70	7	bond	bond	NOUN
bjp-19065	70	8	and	and	CCONJ
bjp-19065	70	9	pі	pі	ADJ
bjp-19065	70	10	-	-	PUNCT
bjp-19065	70	11	pi	pi	NOUN
bjp-19065	70	12	interactions	interaction	NOUN
bjp-19065	70	13	.	.	PUNCT
bjp-19065	71	1	the	the	DET
bjp-19065	71	2	nh2	nh2	PROPN
bjp-19065	71	3	of	of	ADP
bjp-19065	71	4	arg179	arg179	PROPN
bjp-19065	71	5	is	be	AUX
bjp-19065	71	6	forming	form	VERB
bjp-19065	71	7	a	a	DET
bjp-19065	71	8	hydrogen	hydrogen	NOUN
bjp-19065	71	9	bond	bond	NOUN
bjp-19065	71	10	with	with	ADP
bjp-19065	71	11	o14	o14	NOUN
bjp-19065	71	12	of	of	ADP
bjp-19065	71	13	lead	lead	NOUN
bjp-19065	71	14	compound	compound	NOUN
bjp-19065	71	15	with	with	ADP
bjp-19065	71	16	a	a	DET
bjp-19065	71	17	distance	distance	NOUN
bjp-19065	71	18	of	of	ADP
bjp-19065	71	19	2.55	2.55	NUM
bjp-19065	71	20	ǻ	ǻ	NOUN
bjp-19065	71	21	.	.	PUNCT
bjp-19065	72	1	the	the	DET
bjp-19065	72	2	lone	lone	ADJ
bjp-19065	72	3	pі	pі	PROPN
bjp-19065	72	4	-	-	PUNCT
bjp-19065	72	5	pi	pi	NOUN
bjp-19065	72	6	interaction	interaction	NOUN
bjp-19065	72	7	is	be	AUX
bjp-19065	72	8	between	between	ADP
bjp-19065	72	9	phe74	phe74	NOUN
bjp-19065	72	10	of	of	ADP
bjp-19065	72	11	il-6	il-6	NOUN
bjp-19065	72	12	and	and	CCONJ
bjp-19065	72	13	lead	lead	VERB
bjp-19065	72	14	5	5	NUM
bjp-19065	72	15	.	.	PUNCT
bjp-19065	73	1	the	the	DET
bjp-19065	73	2	binding	bind	VERB
bjp-19065	73	3	pocked	pocked	NOUN
bjp-19065	73	4	of	of	ADP
bjp-19065	73	5	the	the	DET
bjp-19065	73	6	lead	lead	NOUN
bjp-19065	73	7	comprises	comprise	NOUN
bjp-19065	73	8	of	of	ADP
bjp-19065	73	9	leu33	leu33	NOUN
bjp-19065	73	10	,	,	PUNCT
bjp-19065	73	11	cys73	cys73	PROPN
bjp-19065	73	12	,	,	PUNCT
bjp-19065	73	13	phe74	phe74	ADJ
bjp-19065	73	14	,	,	PUNCT
bjp-19065	73	15	gln75	gln75	INTJ
bjp-19065	73	16	,	,	PUNCT
bjp-19065	73	17	leu174	leu174	PROPN
bjp-19065	73	18	,	,	PUNCT
bjp-19065	73	19	gln175	gln175	PROPN
bjp-19065	73	20	,	,	PUNCT
bjp-19065	73	21	ser176	ser176	PROPN
bjp-19065	73	22	,	,	PUNCT
bjp-19065	73	23	leu178	leu178	PROPN
bjp-19065	73	24	,	,	PUNCT
bjp-19065	73	25	arg	arg	NOUN
bjp-19065	73	26	179	179	NUM
bjp-19065	73	27	and	and	CCONJ
bjp-19065	73	28	arg	arg	VERB
bjp-19065	73	29	182	182	NUM
bjp-19065	73	30	.	.	PUNCT
bjp-19065	74	1	all	all	DET
bjp-19065	74	2	the	the	DET
bjp-19065	74	3	five	five	NUM
bjp-19065	74	4	compounds	compound	NOUN
bjp-19065	74	5	are	be	AUX
bjp-19065	74	6	of	of	ADP
bjp-19065	74	7	natural	natural	ADJ
bjp-19065	74	8	origin	origin	NOUN
bjp-19065	74	9	having	have	VERB
bjp-19065	74	10	tremendous	tremendous	ADJ
bjp-19065	74	11	potential	potential	NOUN
bjp-19065	74	12	in	in	ADP
bjp-19065	74	13	blocking	block	VERB
bjp-19065	74	14	il-6	il-6	CCONJ
bjp-19065	74	15	activity	activity	NOUN
bjp-19065	74	16	and	and	CCONJ
bjp-19065	74	17	are	be	AUX
bjp-19065	74	18	providing	provide	VERB
bjp-19065	74	19	an	an	DET
bjp-19065	74	20	opportunity	opportunity	NOUN
bjp-19065	74	21	for	for	ADP
bjp-19065	74	22	further	far	ADV
bjp-19065	74	23	in	in	ADP
bjp-19065	74	24	vitro	vitro	X
bjp-19065	74	25	and	and	CCONJ
bjp-19065	74	26	in	in	ADP
bjp-19065	74	27	vivo	vivo	ADJ
bjp-19065	74	28	analysis	analysis	NOUN
bjp-19065	74	29	.	.	PUNCT
bjp-19065	75	1	our	our	PRON
bjp-19065	75	2	approach	approach	NOUN
bjp-19065	75	3	of	of	ADP
bjp-19065	75	4	computer	computer	NOUN
bjp-19065	75	5	aided	aid	VERB
bjp-19065	75	6	drug	drug	NOUN
bjp-19065	75	7	designing	designing	NOUN
bjp-19065	75	8	has	have	AUX
bjp-19065	75	9	helped	help	VERB
bjp-19065	75	10	us	we	PRON
bjp-19065	75	11	in	in	ADP
bjp-19065	75	12	limiting	limit	VERB
bjp-19065	75	13	our	our	PRON
bjp-19065	75	14	focus	focus	NOUN
bjp-19065	75	15	to	to	ADP
bjp-19065	75	16	mere	mere	ADJ
bjp-19065	75	17	0.01	0.01	NUM
bjp-19065	75	18	%	%	NOUN
bjp-19065	75	19	of	of	ADP
bjp-19065	75	20	the	the	DET
bjp-19065	75	21	total	total	ADJ
bjp-19065	75	22	volume	volume	NOUN
bjp-19065	75	23	of	of	ADP
bjp-19065	75	24	inter	inter	PROPN
bjp-19065	75	25	bio	bio	PROPN
bjp-19065	75	26	screen	screen	PROPN
bjp-19065	75	27	database	database	NOUN
bjp-19065	75	28	of	of	ADP
bjp-19065	75	29	around	around	ADV
bjp-19065	75	30	fifty	fifty	NUM
bjp-19065	75	31	thousand	thousand	NUM
bjp-19065	75	32	compounds	compound	NOUN
bjp-19065	75	33	(	(	PUNCT
bjp-19065	75	34	figure	figure	NOUN
bjp-19065	75	35	5	5	NUM
bjp-19065	75	36	)	)	PUNCT
bjp-19065	75	37	.	.	PUNCT
bjp-19065	76	1	out	out	ADP
bjp-19065	76	2	of	of	ADP
bjp-19065	76	3	the	the	DET
bjp-19065	76	4	five	five	NUM
bjp-19065	76	5	compounds	compound	NOUN
bjp-19065	76	6	only	only	ADV
bjp-19065	76	7	lead	lead	VERB
bjp-19065	76	8	1	1	NUM
bjp-19065	76	9	source	source	NOUN
bjp-19065	76	10	could	could	AUX
bjp-19065	76	11	be	be	AUX
bjp-19065	76	12	confirmed	confirm	VERB
bjp-19065	76	13	,	,	PUNCT
bjp-19065	76	14	this	this	DET
bjp-19065	76	15	particular	particular	ADJ
bjp-19065	76	16	compound	compound	NOUN
bjp-19065	76	17	is	be	AUX
bjp-19065	76	18	known	know	VERB
bjp-19065	76	19	as	as	ADP
bjp-19065	76	20	margaric	margaric	ADJ
bjp-19065	76	21	acid	acid	NOUN
bjp-19065	76	22	a	a	DET
bjp-19065	76	23	fatty	fatty	NOUN
bjp-19065	76	24	acid	acid	NOUN
bjp-19065	76	25	found	find	VERB
bjp-19065	76	26	in	in	ADP
bjp-19065	76	27	fat	fat	NOUN
bjp-19065	76	28	and	and	CCONJ
bjp-19065	76	29	milk	milk	NOUN
bjp-19065	76	30	fat	fat	NOUN
bjp-19065	76	31	of	of	ADP
bjp-19065	76	32	ruminants	ruminant	NOUN
bjp-19065	76	33	(	(	PUNCT
bjp-19065	76	34	cooke	cooke	PROPN
bjp-19065	76	35	et	et	PROPN
bjp-19065	76	36	al	al	PROPN
bjp-19065	76	37	.	.	PROPN
bjp-19065	76	38	,	,	PUNCT
bjp-19065	76	39	1957	1957	NUM
bjp-19065	76	40	)	)	PUNCT
bjp-19065	76	41	.	.	PUNCT
bjp-19065	77	1	margeric	margeric	ADJ
bjp-19065	77	2	acid	acid	PROPN
bjp-19065	77	3	is	be	AUX
bjp-19065	77	4	also	also	ADV
bjp-19065	77	5	found	find	VERB
bjp-19065	77	6	in	in	ADP
bjp-19065	77	7	the	the	DET
bjp-19065	77	8	contents	content	NOUN
bjp-19065	77	9	of	of	ADP
bjp-19065	77	10	imitation	imitation	NOUN
bjp-19065	77	11	butter	butter	NOUN
bjp-19065	77	12	famously	famously	ADV
bjp-19065	77	13	known	know	VERB
bjp-19065	77	14	as	as	ADP
bjp-19065	77	15	374	374	NUM
bjp-19065	77	16	bangladesh	bangladesh	NOUN
bjp-19065	77	17	j	j	PROPN
bjp-19065	77	18	pharmacol	pharmacol	PROPN
bjp-19065	77	19	2014	2014	NUM
bjp-19065	77	20	;	;	PUNCT
bjp-19065	77	21	9	9	NUM
bjp-19065	77	22	:	:	SYM
bjp-19065	77	23	371	371	NUM
bjp-19065	77	24	-	-	SYM
bjp-19065	77	25	376	376	NUM
bjp-19065	77	26	figure	figure	NOUN
bjp-19065	77	27	3	3	NUM
bjp-19065	77	28	:	:	PUNCT
bjp-19065	77	29	2d	2d	NUM
bjp-19065	77	30	docked	dock	VERB
bjp-19065	77	31	conformation	conformation	NOUN
bjp-19065	77	32	of	of	ADP
bjp-19065	77	33	five	five	NUM
bjp-19065	77	34	lead	lead	NOUN
bjp-19065	77	35	compounds	compound	NOUN
bjp-19065	77	36	with	with	ADP
bjp-19065	77	37	il-6	il-6	NOUN
bjp-19065	77	38	margarine	margarine	NOUN
bjp-19065	77	39	.	.	PUNCT
bjp-19065	78	1	as	as	SCONJ
bjp-19065	78	2	fatty	fatty	NOUN
bjp-19065	78	3	acids	acid	NOUN
bjp-19065	78	4	are	be	AUX
bjp-19065	78	5	already	already	ADV
bjp-19065	78	6	reported	report	VERB
bjp-19065	78	7	to	to	PART
bjp-19065	78	8	have	have	VERB
bjp-19065	78	9	anti	anti	ADJ
bjp-19065	78	10	inflammatory	inflammatory	ADJ
bjp-19065	78	11	effects	effect	NOUN
bjp-19065	78	12	(	(	PUNCT
bjp-19065	78	13	khalil	khalil	PROPN
bjp-19065	78	14	et	et	PROPN
bjp-19065	78	15	al	al	PROPN
bjp-19065	78	16	.	.	PROPN
bjp-19065	78	17	,	,	PUNCT
bjp-19065	78	18	2000	2000	NUM
bjp-19065	78	19	)	)	PUNCT
bjp-19065	78	20	makes	make	VERB
bjp-19065	78	21	lead	lead	VERB
bjp-19065	78	22	1	1	NUM
bjp-19065	78	23	the	the	DET
bjp-19065	78	24	most	most	ADV
bjp-19065	78	25	significant	significant	ADJ
bjp-19065	78	26	of	of	ADP
bjp-19065	78	27	the	the	DET
bjp-19065	78	28	five	five	NUM
bjp-19065	78	29	shortlisted	shortlist	VERB
bjp-19065	78	30	compounds	compound	NOUN
bjp-19065	78	31	.	.	PUNCT
bjp-19065	79	1	this	this	DET
bjp-19065	79	2	particular	particular	ADJ
bjp-19065	79	3	selected	select	VERB
bjp-19065	79	4	natural	natural	ADJ
bjp-19065	79	5	compound	compound	NOUN
bjp-19065	79	6	we	we	PRON
bjp-19065	79	7	feel	feel	VERB
bjp-19065	79	8	holds	hold	VERB
bjp-19065	79	9	an	an	DET
bjp-19065	79	10	edge	edge	NOUN
bjp-19065	79	11	over	over	ADP
bjp-19065	79	12	the	the	DET
bjp-19065	79	13	selected	select	VERB
bjp-19065	79	14	four	four	NUM
bjp-19065	79	15	other	other	ADJ
bjp-19065	79	16	compounds	compound	NOUN
bjp-19065	79	17	and	and	CCONJ
bjp-19065	79	18	can	can	AUX
bjp-19065	79	19	be	be	AUX
bjp-19065	79	20	crucial	crucial	ADJ
bjp-19065	79	21	in	in	ADP
bjp-19065	79	22	blocking	block	VERB
bjp-19065	79	23	considerably	considerably	ADV
bjp-19065	79	24	elevated	elevate	VERB
bjp-19065	79	25	il-6	il-6	NOUN
bjp-19065	79	26	in	in	ADP
bjp-19065	79	27	the	the	DET
bjp-19065	79	28	serum	serum	NOUN
bjp-19065	79	29	of	of	ADP
bjp-19065	79	30	rheumatoid	rheumatoid	VERB
bjp-19065	79	31	arthritis	arthritis	NOUN
bjp-19065	79	32	patients	patient	NOUN
bjp-19065	79	33	.	.	PUNCT
bjp-19065	80	1	contribution	contribution	NOUN
bjp-19065	80	2	first	first	ADJ
bjp-19065	80	3	two	two	NUM
bjp-19065	80	4	authors	author	NOUN
bjp-19065	80	5	contributed	contribute	VERB
bjp-19065	80	6	equally	equally	ADV
bjp-19065	80	7	in	in	ADP
bjp-19065	80	8	this	this	DET
bjp-19065	80	9	study	study	NOUN
bjp-19065	80	10	.	.	PUNCT
bjp-19065	81	1	references	reference	NOUN
bjp-19065	81	2	alvarez	alvarez	PROPN
bjp-19065	81	3	jc	jc	PROPN
bjp-19065	81	4	.	.	PROPN
bjp-19065	82	1	high	high	ADJ
bjp-19065	82	2	-	-	PUNCT
bjp-19065	82	3	throughput	throughput	NOUN
bjp-19065	82	4	docking	docking	NOUN
bjp-19065	82	5	as	as	ADP
bjp-19065	82	6	a	a	DET
bjp-19065	82	7	source	source	NOUN
bjp-19065	82	8	of	of	ADP
bjp-19065	82	9	novel	novel	ADJ
bjp-19065	82	10	drug	drug	NOUN
bjp-19065	82	11	leads	lead	NOUN
bjp-19065	82	12	.	.	PUNCT
bjp-19065	83	1	curr	curr	PROPN
bjp-19065	83	2	opin	opin	NOUN
bjp-19065	83	3	chem	chem	NOUN
bjp-19065	83	4	biol	biol	NOUN
bjp-19065	83	5	.	.	PUNCT
bjp-19065	84	1	2004	2004	NUM
bjp-19065	84	2	;	;	PUNCT
bjp-19065	84	3	8	8	NUM
bjp-19065	84	4	:	:	SYM
bjp-19065	84	5	365	365	NUM
bjp-19065	84	6	-	-	SYM
bjp-19065	84	7	70	70	NUM
bjp-19065	84	8	.	.	PUNCT
bjp-19065	85	1	chikan	chikan	PROPN
bjp-19065	85	2	na	na	PROPN
bjp-19065	85	3	,	,	PUNCT
bjp-19065	85	4	bhavaniprasad	bhavaniprasad	NOUN
bjp-19065	85	5	v	v	NOUN
bjp-19065	85	6	,	,	PUNCT
bjp-19065	85	7	anbarasu	anbarasu	PROPN
bjp-19065	85	8	k	k	NOUN
bjp-19065	85	9	,	,	PUNCT
bjp-19065	85	10	shabir	shabir	PROPN
bjp-19065	85	11	n	n	CCONJ
bjp-19065	85	12	,	,	PUNCT
bjp-19065	85	13	patel	patel	PROPN
bjp-19065	85	14	tn	tn	PROPN
bjp-19065	85	15	.	.	PROPN
bjp-19065	85	16	from	from	ADP
bjp-19065	85	17	natural	natural	ADJ
bjp-19065	85	18	products	product	NOUN
bjp-19065	85	19	to	to	ADP
bjp-19065	85	20	drugs	drug	NOUN
bjp-19065	85	21	for	for	ADP
bjp-19065	85	22	epimutation	epimutation	NOUN
bjp-19065	85	23	computer	computer	NOUN
bjp-19065	85	24	-	-	PUNCT
bjp-19065	85	25	aided	aid	VERB
bjp-19065	85	26	drug	drug	NOUN
bjp-19065	85	27	design	design	NOUN
bjp-19065	85	28	.	.	PUNCT
bjp-19065	86	1	appl	appl	PROPN
bjp-19065	86	2	biochem	biochem	PROPN
bjp-19065	86	3	biotechnol	biotechnol	PROPN
bjp-19065	86	4	.	.	PUNCT
bjp-19065	87	1	2013	2013	NUM
bjp-19065	87	2	;	;	PUNCT
bjp-19065	87	3	170	170	NUM
bjp-19065	87	4	:	:	SYM
bjp-19065	87	5	164	164	NUM
bjp-19065	87	6	-	-	SYM
bjp-19065	87	7	75	75	NUM
bjp-19065	87	8	.	.	PUNCT
bjp-19065	88	1	cooke	cooke	PROPN
bjp-19065	88	2	nj	nj	PROPN
bjp-19065	88	3	,	,	PUNCT
bjp-19065	88	4	hansen	hansen	PROPN
bjp-19065	88	5	rp	rp	PROPN
bjp-19065	88	6	,	,	PUNCT
bjp-19065	88	7	shorland	shorland	PROPN
bjp-19065	88	8	fb	fb	INTJ
bjp-19065	88	9	.	.	PUNCT
bjp-19065	88	10	occurrence	occurrence	NOUN
bjp-19065	88	11	in	in	ADP
bjp-19065	88	12	butterfat	butterfat	NOUN
bjp-19065	88	13	of	of	ADP
bjp-19065	88	14	n	n	CCONJ
bjp-19065	88	15	-	-	PUNCT
bjp-19065	88	16	heptadecanoic	heptadecanoic	ADJ
bjp-19065	88	17	acid	acid	NOUN
bjp-19065	88	18	(	(	PUNCT
bjp-19065	88	19	margaric	margaric	ADJ
bjp-19065	88	20	acid	acid	NOUN
bjp-19065	88	21	)	)	PUNCT
bjp-19065	88	22	.	.	PUNCT
bjp-19065	89	1	nature	nature	NOUN
bjp-19065	89	2	1957	1957	NUM
bjp-19065	89	3	;	;	PUNCT
bjp-19065	89	4	179	179	NUM
bjp-19065	89	5	:	:	SYM
bjp-19065	89	6	98	98	NUM
bjp-19065	89	7	.	.	X
bjp-19065	90	1	davis	davis	PROPN
bjp-19065	90	2	am	am	PROPN
bjp-19065	90	3	,	,	PUNCT
bjp-19065	90	4	riley	riley	PROPN
bjp-19065	90	5	rj	rj	PROPN
bjp-19065	90	6	.	.	PUNCT
bjp-19065	91	1	predictive	predictive	PROPN
bjp-19065	91	2	admet	admet	PROPN
bjp-19065	91	3	studies	study	NOUN
bjp-19065	91	4	,	,	PUNCT
bjp-19065	91	5	the	the	DET
bjp-19065	91	6	challenges	challenge	NOUN
bjp-19065	91	7	bangladesh	bangladesh	PROPN
bjp-19065	91	8	j	j	PROPN
bjp-19065	91	9	pharmacol	pharmacol	PROPN
bjp-19065	91	10	2014	2014	NUM
bjp-19065	91	11	;	;	PUNCT
bjp-19065	91	12	9	9	NUM
bjp-19065	91	13	:	:	SYM
bjp-19065	91	14	371	371	NUM
bjp-19065	91	15	-	-	SYM
bjp-19065	91	16	376	376	NUM
bjp-19065	91	17	375	375	NUM
bjp-19065	91	18	residue	residue	NOUN
bjp-19065	91	19	interaction	interaction	NOUN
bjp-19065	91	20	electrostatic	electrostatic	ADJ
bjp-19065	91	21	van	van	PROPN
bjp-19065	91	22	der	der	NOUN
bjp-19065	91	23	waals	waal	NOUN
bjp-19065	91	24	covalent	covalent	NOUN
bjp-19065	91	25	bond	bond	NOUN
bjp-19065	91	26	water	water	NOUN
bjp-19065	91	27	metal	metal	NOUN
bjp-19065	91	28	figure	figure	NOUN
bjp-19065	91	29	4	4	NUM
bjp-19065	91	30	:	:	PUNCT
bjp-19065	91	31	3d	3d	NUM
bjp-19065	91	32	mapping	mapping	NOUN
bjp-19065	91	33	of	of	ADP
bjp-19065	91	34	lead	lead	NOUN
bjp-19065	91	35	compounds	compound	NOUN
bjp-19065	91	36	with	with	ADP
bjp-19065	91	37	their	their	PRON
bjp-19065	91	38	respective	respective	ADJ
bjp-19065	91	39	hits	hit	NOUN
bjp-19065	91	40	where	where	SCONJ
bjp-19065	91	41	(	(	PUNCT
bjp-19065	91	42	a	a	PRON
bjp-19065	91	43	,	,	PUNCT
bjp-19065	91	44	b	b	NOUN
bjp-19065	91	45	,	,	PUNCT
bjp-19065	91	46	c	c	NOUN
bjp-19065	91	47	and	and	CCONJ
bjp-19065	91	48	e	e	X
bjp-19065	91	49	)	)	PUNCT
bjp-19065	91	50	represent	represent	VERB
bjp-19065	91	51	the	the	DET
bjp-19065	91	52	lead	lead	NOUN
bjp-19065	91	53	compounds	compound	NOUN
bjp-19065	91	54	in	in	ADP
bjp-19065	91	55	order	order	NOUN
bjp-19065	91	56	a	a	DET
bjp-19065	91	57	b	b	NOUN
bjp-19065	91	58	c	c	NOUN
bjp-19065	91	59	d	d	X
bjp-19065	91	60	e	e	X
bjp-19065	91	61	figure	figure	NOUN
bjp-19065	91	62	5	5	NUM
bjp-19065	91	63	:	:	PUNCT
bjp-19065	91	64	3d	3d	NUM
bjp-19065	91	65	point	point	NOUN
bjp-19065	91	66	plot	plot	NOUN
bjp-19065	91	67	of	of	ADP
bjp-19065	91	68	four	four	NUM
bjp-19065	91	69	properties	property	NOUN
bjp-19065	91	70	(	(	PUNCT
bjp-19065	91	71	hba	hba	NOUN
bjp-19065	91	72	,	,	PUNCT
bjp-19065	91	73	hbd	hbd	NOUN
bjp-19065	91	74	,	,	PUNCT
bjp-19065	91	75	clogp	clogp	ADJ
bjp-19065	91	76	,	,	PUNCT
bjp-19065	91	77	and	and	CCONJ
bjp-19065	91	78	tpsa	tpsa	PROPN
bjp-19065	91	79	)	)	PUNCT
bjp-19065	91	80	of	of	ADP
bjp-19065	91	81	the	the	DET
bjp-19065	91	82	compounds	compound	NOUN
bjp-19065	91	83	at	at	ADP
bjp-19065	91	84	different	different	ADJ
bjp-19065	91	85	stages	stage	NOUN
bjp-19065	91	86	of	of	ADP
bjp-19065	91	87	drug	drug	NOUN
bjp-19065	91	88	discovery	discovery	NOUN
bjp-19065	91	89	,	,	PUNCT
bjp-19065	91	90	showing	show	VERB
bjp-19065	91	91	the	the	DET
bjp-19065	91	92	journey	journey	NOUN
bjp-19065	91	93	from	from	ADP
bjp-19065	91	94	~	~	PUNCT
bjp-19065	91	95	50000	50000	NUM
bjp-19065	91	96	compounds	compound	NOUN
bjp-19065	91	97	to	to	PART
bjp-19065	91	98	top	top	VERB
bjp-19065	91	99	five	five	NUM
bjp-19065	91	100	in	in	ADP
bjp-19065	91	101	accordance	accordance	NOUN
bjp-19065	91	102	with	with	ADP
bjp-19065	91	103	lipinski	lipinski	PROPN
bjp-19065	91	104	’s	’s	PART
bjp-19065	91	105	parameters	parameter	NOUN
bjp-19065	91	106	and	and	CCONJ
bjp-19065	91	107	the	the	DET
bjp-19065	91	108	opportunities	opportunity	NOUN
bjp-19065	91	109	.	.	PUNCT
bjp-19065	92	1	curr	curr	PROPN
bjp-19065	92	2	opin	opin	NOUN
bjp-19065	92	3	chem	chem	NOUN
bjp-19065	92	4	biol	biol	NOUN
bjp-19065	92	5	.	.	PUNCT
bjp-19065	93	1	2004	2004	NUM
bjp-19065	93	2	;	;	PUNCT
bjp-19065	93	3	8	8	NUM
bjp-19065	93	4	:	:	SYM
bjp-19065	93	5	378	378	NUM
bjp-19065	93	6	-	-	SYM
bjp-19065	93	7	86	86	NUM
bjp-19065	93	8	.	.	PUNCT
bjp-19065	94	1	fontaine	fontaine	PROPN
bjp-19065	94	2	v	v	PROPN
bjp-19065	94	3	,	,	PUNCT
bjp-19065	94	4	savino	savino	PROPN
bjp-19065	94	5	r	r	PROPN
bjp-19065	94	6	,	,	PUNCT
bjp-19065	94	7	arcone	arcone	NOUN
bjp-19065	94	8	r	r	NOUN
bjp-19065	94	9	,	,	PUNCT
bjp-19065	94	10	de	de	X
bjp-19065	94	11	wit	wit	ADJ
bjp-19065	94	12	l	l	NOUN
bjp-19065	94	13	,	,	PUNCT
bjp-19065	94	14	brakenhoff	brakenhoff	NOUN
bjp-19065	94	15	jp	jp	NOUN
bjp-19065	94	16	,	,	PUNCT
bjp-19065	94	17	content	content	PROPN
bjp-19065	94	18	j	j	PROPN
bjp-19065	94	19	,	,	PUNCT
bjp-19065	94	20	ciliberto	ciliberto	PROPN
bjp-19065	94	21	g.	g.	PROPN
bjp-19065	94	22	involvement	involvement	NOUN
bjp-19065	94	23	of	of	ADP
bjp-19065	94	24	the	the	DET
bjp-19065	94	25	arg179	arg179	PROPN
bjp-19065	94	26	in	in	ADP
bjp-19065	94	27	the	the	DET
bjp-19065	94	28	acti	acti	PROPN
bjp-19065	94	29	ve	ve	NOUN
bjp-19065	94	30	site	site	NOUN
bjp-19065	94	31	of	of	ADP
bjp-19065	94	32	human	human	PROPN
bjp-19065	94	33	il-6	il-6	NOUN
bjp-19065	94	34	.	.	PUNCT
bjp-19065	95	1	eur	eur	PROPN
bjp-19065	95	2	j	j	PROPN
bjp-19065	95	3	biochem	biochem	PROPN
bjp-19065	95	4	.	.	PUNCT
bjp-19065	96	1	1993	1993	NUM
bjp-19065	96	2	;	;	PUNCT
bjp-19065	96	3	211	211	NUM
bjp-19065	96	4	:	:	PUNCT
bjp-19065	96	5	749	749	NUM
bjp-19065	96	6	-	-	SYM
bjp-19065	96	7	55	55	NUM
bjp-19065	96	8	.	.	PUNCT
bjp-19065	97	1	gaffen	gaffen	PROPN
bjp-19065	97	2	sl	sl	PROPN
bjp-19065	97	3	.	.	PUNCT
bjp-19065	98	1	the	the	DET
bjp-19065	98	2	role	role	NOUN
bjp-19065	98	3	of	of	ADP
bjp-19065	98	4	interleukin-17	interleukin-17	PROPN
bjp-19065	98	5	in	in	ADP
bjp-19065	98	6	the	the	DET
bjp-19065	98	7	pathogenesis	pathogenesis	NOUN
bjp-19065	98	8	of	of	ADP
bjp-19065	98	9	rheumatoid	rheumatoid	NOUN
bjp-19065	98	10	arthritis	arthritis	NOUN
bjp-19065	98	11	.	.	PUNCT
bjp-19065	99	1	curr	curr	PROPN
bjp-19065	99	2	rheumatol	rheumatol	PROPN
bjp-19065	99	3	rep	rep	PROPN
bjp-19065	99	4	.	.	PROPN
bjp-19065	99	5	2011	2011	NUM
bjp-19065	99	6	;	;	PUNCT
bjp-19065	99	7	11	11	NUM
bjp-19065	99	8	:	:	SYM
bjp-19065	99	9	365	365	NUM
bjp-19065	99	10	-	-	SYM
bjp-19065	99	11	70	70	NUM
bjp-19065	99	12	.	.	PUNCT
bjp-19065	100	1	gravallese	gravallese	VERB
bjp-19065	100	2	em	em	PRON
bjp-19065	100	3	,	,	PUNCT
bjp-19065	100	4	manning	man	VERB
bjp-19065	100	5	c	c	NUM
bjp-19065	100	6	,	,	PUNCT
bjp-19065	100	7	tsay	tsay	PROPN
bjp-19065	100	8	a	a	PRON
bjp-19065	100	9	,	,	PUNCT
bjp-19065	100	10	naito	naito	PROPN
bjp-19065	100	11	a	a	PROPN
bjp-19065	100	12	,	,	PUNCT
bjp-19065	100	13	pan	pan	NOUN
bjp-19065	100	14	c	c	NOUN
bjp-19065	100	15	,	,	PUNCT
bjp-19065	100	16	amento	amento	ADJ
bjp-19065	100	17	e	e	NOUN
bjp-19065	100	18	,	,	PUNCT
bjp-19065	100	19	goldring	goldring	PROPN
bjp-19065	100	20	sr	sr	PROPN
bjp-19065	100	21	.	.	PUNCT
bjp-19065	101	1	synovial	synovial	ADJ
bjp-19065	101	2	tissue	tissue	NOUN
bjp-19065	101	3	in	in	ADP
bjp-19065	101	4	rheumatoid	rheumatoid	NOUN
bjp-19065	101	5	arthritis	arthritis	NOUN
bjp-19065	101	6	is	be	AUX
bjp-19065	101	7	a	a	DET
bjp-19065	101	8	source	source	NOUN
bjp-19065	101	9	of	of	ADP
bjp-19065	101	10	osteoclast	osteoclast	ADJ
bjp-19065	101	11	differentiation	differentiation	NOUN
bjp-19065	101	12	factor	factor	NOUN
bjp-19065	101	13	.	.	PUNCT
bjp-19065	102	1	arthritis	arthritis	NOUN
bjp-19065	102	2	rheum	rheum	NOUN
bjp-19065	102	3	.	.	PUNCT
bjp-19065	103	1	2000	2000	NUM
bjp-19065	103	2	;	;	PUNCT
bjp-19065	103	3	43	43	NUM
bjp-19065	103	4	:	:	PUNCT
bjp-19065	103	5	250	250	NUM
bjp-19065	103	6	-	-	SYM
bjp-19065	103	7	58	58	NUM
bjp-19065	103	8	.	.	PUNCT
bjp-19065	104	1	hashizume	hashizume	PROPN
bjp-19065	104	2	m	m	PROPN
bjp-19065	104	3	,	,	PUNCT
bjp-19065	104	4	yoshida	yoshida	PROPN
bjp-19065	104	5	h	h	PROPN
bjp-19065	104	6	,	,	PUNCT
bjp-19065	104	7	koike	koike	PROPN
bjp-19065	104	8	n	n	CCONJ
bjp-19065	104	9	,	,	PUNCT
bjp-19065	104	10	suzuki	suzuki	PROPN
bjp-19065	104	11	m	m	PROPN
bjp-19065	104	12	,	,	PUNCT
bjp-19065	104	13	mihara	mihara	PROPN
bjp-19065	104	14	m.	m.	PROPN
bjp-19065	104	15	overproduced	overproduce	VERB
bjp-19065	104	16	interleukin	interleukin	NOUN
bjp-19065	104	17	6	6	NUM
bjp-19065	104	18	decreases	decrease	VERB
bjp-19065	104	19	blood	blood	NOUN
bjp-19065	104	20	lipid	lipid	NOUN
bjp-19065	104	21	levels	level	NOUN
bjp-19065	104	22	via	via	ADP
bjp-19065	104	23	up	up	ADP
bjp-19065	104	24	-	-	PUNCT
bjp-19065	104	25	regulation	regulation	NOUN
bjp-19065	104	26	of	of	ADP
bjp-19065	104	27	very	very	ADV
bjp-19065	104	28	-	-	PUNCT
bjp-19065	104	29	low	low	ADJ
bjp-19065	104	30	-	-	PUNCT
bjp-19065	104	31	density	density	NOUN
bjp-19065	104	32	lipoprotein	lipoprotein	ADJ
bjp-19065	104	33	receptor	receptor	NOUN
bjp-19065	104	34	.	.	PUNCT
bjp-19065	105	1	ann	ann	PROPN
bjp-19065	105	2	rheum	rheum	PROPN
bjp-19065	105	3	dis	dis	PROPN
bjp-19065	105	4	.	.	PUNCT
bjp-19065	106	1	2010	2010	NUM
bjp-19065	106	2	;	;	PUNCT
bjp-19065	106	3	69	69	NUM
bjp-19065	106	4	:	:	PUNCT
bjp-19065	106	5	741	741	NUM
bjp-19065	106	6	-	-	SYM
bjp-19065	106	7	46	46	NUM
bjp-19065	106	8	.	.	PUNCT
bjp-19065	107	1	hochberg	hochberg	PROPN
bjp-19065	107	2	mc	mc	PROPN
bjp-19065	107	3	,	,	PUNCT
bjp-19065	107	4	arnold	arnold	PROPN
bjp-19065	107	5	cm	cm	PROPN
bjp-19065	107	6	,	,	PUNCT
bjp-19065	107	7	hogans	hogans	PROPN
bjp-19065	107	8	bb	bb	PROPN
bjp-19065	107	9	,	,	PUNCT
bjp-19065	107	10	spivak	spivak	PROPN
bjp-19065	107	11	jl	jl	PROPN
bjp-19065	107	12	.	.	PUNCT
bjp-19065	108	1	serum	serum	VERB
bjp-19065	108	2	immunoreactive	immunoreactive	ADJ
bjp-19065	108	3	erythropoietin	erythropoietin	NOUN
bjp-19065	108	4	in	in	ADP
bjp-19065	108	5	rheumatoid	rheumatoid	NOUN
bjp-19065	108	6	arthritis	arthritis	NOUN
bjp-19065	108	7	:	:	PUNCT
bjp-19065	108	8	impaired	impaired	ADJ
bjp-19065	108	9	response	response	NOUN
bjp-19065	108	10	to	to	ADP
bjp-19065	108	11	anemia	anemia	NOUN
bjp-19065	108	12	.	.	PUNCT
bjp-19065	109	1	arthritis	arthritis	NOUN
bjp-19065	109	2	rheum	rheum	NOUN
bjp-19065	109	3	.	.	PUNCT
bjp-19065	110	1	1988	1988	NUM
bjp-19065	110	2	;	;	PUNCT
bjp-19065	110	3	31	31	NUM
bjp-19065	110	4	:	:	SYM
bjp-19065	110	5	1318	1318	NUM
bjp-19065	110	6	-	-	SYM
bjp-19065	110	7	21	21	NUM
bjp-19065	110	8	.	.	PUNCT
bjp-19065	111	1	houssiau	houssiau	PROPN
bjp-19065	111	2	fa	fa	PROPN
bjp-19065	111	3	,	,	PUNCT
bjp-19065	111	4	devogelaer	devogelaer	PROPN
bjp-19065	111	5	jp	jp	NOUN
bjp-19065	111	6	,	,	PUNCT
bjp-19065	111	7	van	van	PROPN
bjp-19065	111	8	damme	damme	PROPN
bjp-19065	111	9	j	j	PROPN
bjp-19065	111	10	,	,	PUNCT
bjp-19065	111	11	de	de	PROPN
bjp-19065	111	12	deuxchaisnes	deuxchaisne	NOUN
bjp-19065	111	13	cn	cn	PROPN
bjp-19065	111	14	,	,	PUNCT
bjp-19065	111	15	van	van	PROPN
bjp-19065	111	16	snick	snick	PROPN
bjp-19065	111	17	j.	j.	PROPN
bjp-19065	111	18	interleukin-6	interleukin-6	PROPN
bjp-19065	111	19	in	in	ADP
bjp-19065	111	20	synovial	synovial	ADJ
bjp-19065	111	21	fluid	fluid	NOUN
bjp-19065	111	22	and	and	CCONJ
bjp-19065	111	23	serum	serum	NOUN
bjp-19065	111	24	of	of	ADP
bjp-19065	111	25	patients	patient	NOUN
bjp-19065	111	26	with	with	ADP
bjp-19065	111	27	rheumatoidarthritis	rheumatoidarthritis	PROPN
bjp-19065	111	28	and	and	CCONJ
bjp-19065	111	29	other	other	ADJ
bjp-19065	111	30	inflam	inflam	PROPN
bjp-19065	111	31	matory	matory	NOUN
bjp-19065	111	32	arthritides	arthritide	NOUN
bjp-19065	111	33	.	.	PUNCT
bjp-19065	112	1	arthritis	arthritis	NOUN
bjp-19065	112	2	rheum	rheum	NOUN
bjp-19065	112	3	.	.	PUNCT
bjp-19065	113	1	1988	1988	NUM
bjp-19065	113	2	;	;	PUNCT
bjp-19065	113	3	31	31	NUM
bjp-19065	113	4	:	:	PUNCT
bjp-19065	113	5	784	784	NUM
bjp-19065	113	6	-	-	SYM
bjp-19065	113	7	88	88	NUM
bjp-19065	113	8	.	.	PUNCT
bjp-19065	114	1	khalil	khalil	PROPN
bjp-19065	114	2	mh	mh	PROPN
bjp-19065	114	3	,	,	PUNCT
bjp-19065	114	4	marcelletti	marcelletti	PROPN
bjp-19065	114	5	jf	jf	PROPN
bjp-19065	114	6	,	,	PUNCT
bjp-19065	114	7	katz	katz	PROPN
bjp-19065	114	8	lr	lr	PROPN
bjp-19065	114	9	,	,	PUNCT
bjp-19065	114	10	katz	katz	PROPN
bjp-19065	114	11	dh	dh	PROPN
bjp-19065	114	12	,	,	PUNCT
bjp-19065	114	13	pope	pope	PROPN
bjp-19065	114	14	le	le	X
bjp-19065	114	15	.	.	PUNCT
bjp-19065	114	16	topical	topical	ADJ
bjp-19065	114	17	application	application	NOUN
bjp-19065	114	18	of	of	ADP
bjp-19065	114	19	docosanolor	docosanolor	NOUN
bjp-19065	114	20	stearic	stearic	ADJ
bjp-19065	114	21	acid	acid	NOUN
bjp-19065	114	22	-	-	PUNCT
bjp-19065	114	23	containing	contain	VERB
bjp-19065	114	24	creams	cream	NOUN
bjp-19065	114	25	reduces	reduce	VERB
bjp-19065	114	26	severity	severity	NOUN
bjp-19065	114	27	of	of	ADP
bjp-19065	114	28	phenol	phenol	ADJ
bjp-19065	114	29	burn	burn	NOUN
bjp-19065	114	30	wounds	wound	NOUN
bjp-19065	114	31	in	in	ADP
bjp-19065	114	32	mice	mouse	NOUN
bjp-19065	114	33	.	.	PUNCT
bjp-19065	115	1	contact	contact	PROPN
bjp-19065	115	2	dermatitis	dermatitis	NOUN
bjp-19065	115	3	2000	2000	NUM
bjp-19065	115	4	;	;	PUNCT
bjp-19065	115	5	43	43	NUM
bjp-19065	115	6	:	:	SYM
bjp-19065	115	7	79	79	NUM
bjp-19065	115	8	-	-	SYM
bjp-19065	115	9	81	81	NUM
bjp-19065	115	10	.	.	PUNCT
bjp-19065	116	1	klareskog	klareskog	PROPN
bjp-19065	116	2	l	l	PROPN
bjp-19065	116	3	,	,	PUNCT
bjp-19065	116	4	catrina	catrina	PROPN
bjp-19065	116	5	ai	ai	VERB
bjp-19065	116	6	,	,	PUNCT
bjp-19065	116	7	paget	paget	PROPN
bjp-19065	116	8	s.	s.	PROPN
bjp-19065	116	9	rheumatoid	rheumatoid	VERB
bjp-19065	116	10	arthritis	arthritis	NOUN
bjp-19065	116	11	.	.	PUNCT
bjp-19065	117	1	lancet	lancet	PROPN
bjp-19065	117	2	2009	2009	NUM
bjp-19065	117	3	;	;	PUNCT
bjp-19065	117	4	373	373	NUM
bjp-19065	117	5	:	:	PUNCT
bjp-19065	117	6	659	659	NUM
bjp-19065	117	7	-	-	SYM
bjp-19065	117	8	72	72	NUM
bjp-19065	117	9	.	.	PUNCT
bjp-19065	118	1	lipinski	lipinski	PROPN
bjp-19065	118	2	ca	ca	PROPN
bjp-19065	118	3	,	,	PUNCT
bjp-19065	118	4	lombardo	lombardo	PROPN
bjp-19065	118	5	f	f	PROPN
bjp-19065	118	6	,	,	PUNCT
bjp-19065	118	7	dominy	dominy	ADJ
bjp-19065	118	8	bw	bw	NOUN
bjp-19065	118	9	,	,	PUNCT
bjp-19065	118	10	feeney	feeney	PROPN
bjp-19065	118	11	pj	pj	PROPN
bjp-19065	118	12	.	.	PROPN
bjp-19065	119	1	experimental	experimental	ADJ
bjp-19065	119	2	and	and	CCONJ
bjp-19065	119	3	computational	computational	ADJ
bjp-19065	119	4	approaches	approach	NOUN
bjp-19065	119	5	to	to	PART
bjp-19065	119	6	estimate	estimate	VERB
bjp-19065	119	7	solubility	solubility	NOUN
bjp-19065	119	8	and	and	CCONJ
bjp-19065	119	9	permeability	permeability	NOUN
bjp-19065	119	10	in	in	ADP
bjp-19065	119	11	drug	drug	NOUN
bjp-19065	119	12	discovery	discovery	NOUN
bjp-19065	119	13	and	and	CCONJ
bjp-19065	119	14	development	development	NOUN
bjp-19065	119	15	settings	setting	NOUN
bjp-19065	119	16	.	.	PUNCT
bjp-19065	120	1	adv	adv	PROPN
bjp-19065	120	2	drug	drug	PROPN
bjp-19065	120	3	deliv	deliv	PROPN
bjp-19065	120	4	rev	rev	PROPN
bjp-19065	120	5	.	.	PROPN
bjp-19065	120	6	2001	2001	NUM
bjp-19065	120	7	;	;	PUNCT
bjp-19065	120	8	46	46	NUM
bjp-19065	120	9	:	:	SYM
bjp-19065	120	10	3	3	NUM
bjp-19065	120	11	-	-	SYM
bjp-19065	120	12	26	26	NUM
bjp-19065	120	13	.	.	PUNCT
bjp-19065	121	1	lipinski	lipinski	PROPN
bjp-19065	121	2	ca	ca	PROPN
bjp-19065	121	3	.	.	PUNCT
bjp-19065	122	1	lead	lead	VERB
bjp-19065	122	2	-	-	PUNCT
bjp-19065	122	3	and	and	CCONJ
bjp-19065	122	4	drug	drug	NOUN
bjp-19065	122	5	-	-	PUNCT
bjp-19065	122	6	like	like	ADJ
bjp-19065	122	7	compounds	compound	NOUN
bjp-19065	122	8	:	:	PUNCT
bjp-19065	122	9	the	the	DET
bjp-19065	122	10	rule	rule	NOUN
bjp-19065	122	11	-	-	PUNCT
bjp-19065	122	12	of	of	ADP
bjp-19065	122	13	-	-	PUNCT
bjp-19065	122	14	five	five	NUM
bjp-19065	122	15	revolution	revolution	NOUN
bjp-19065	122	16	.	.	PUNCT
bjp-19065	123	1	drug	drug	NOUN
bjp-19065	123	2	discov	discov	PROPN
bjp-19065	123	3	today	today	NOUN
bjp-19065	123	4	technol	technol	NOUN
bjp-19065	123	5	.	.	PUNCT
bjp-19065	123	6	2004	2004	NUM
bjp-19065	123	7	;	;	PUNCT
bjp-19065	123	8	1	1	NUM
bjp-19065	123	9	:	:	SYM
bjp-19065	123	10	337	337	NUM
bjp-19065	123	11	-	-	SYM
bjp-19065	123	12	41	41	NUM
bjp-19065	123	13	.	.	PUNCT
bjp-19065	124	1	madhok	madhok	NOUN
bjp-19065	124	2	r	r	NOUN
bjp-19065	124	3	,	,	PUNCT
bjp-19065	124	4	crilly	crilly	ADV
bjp-19065	124	5	a	a	X
bjp-19065	124	6	,	,	PUNCT
bjp-19065	124	7	watson	watson	PROPN
bjp-19065	124	8	j	j	PROPN
bjp-19065	124	9	,	,	PUNCT
bjp-19065	124	10	capell	capell	PROPN
bjp-19065	124	11	ha	ha	INTJ
bjp-19065	124	12	.	.	PROPN
bjp-19065	124	13	serum	serum	PROPN
bjp-19065	124	14	interleukin6	interleukin6	PROPN
bjp-19065	124	15	levels	level	NOUN
bjp-19065	124	16	in	in	ADP
bjp-19065	124	17	rheumatoid	rheumatoid	NOUN
bjp-19065	124	18	arthritis	arthritis	NOUN
bjp-19065	124	19	:	:	PUNCT
bjp-19065	124	20	correlation	correlation	NOUN
bjp-19065	124	21	with	with	ADP
bjp-19065	124	22	clinical	clinical	ADJ
bjp-19065	124	23	and	and	CCONJ
bjp-19065	124	24	laboratory	laboratory	NOUN
bjp-19065	124	25	indices	index	NOUN
bjp-19065	124	26	of	of	ADP
bjp-19065	124	27	disease	disease	NOUN
bjp-19065	124	28	activity	activity	NOUN
bjp-19065	124	29	.	.	PUNCT
bjp-19065	125	1	ann	ann	PROPN
bjp-19065	125	2	rheum	rheum	PROPN
bjp-19065	125	3	dis	dis	PROPN
bjp-19065	125	4	.	.	PUNCT
bjp-19065	125	5	1993	1993	NUM
bjp-19065	125	6	;	;	PUNCT
bjp-19065	125	7	52	52	NUM
bjp-19065	125	8	:	:	SYM
bjp-19065	125	9	232	232	NUM
bjp-19065	125	10	-	-	SYM
bjp-19065	125	11	34	34	NUM
bjp-19065	125	12	.	.	PUNCT
bjp-19065	125	13	maunz	maunz	PROPN
bjp-19065	125	14	a	a	PROPN
bjp-19065	125	15	,	,	PUNCT
bjp-19065	125	16	gütlein	gütlein	VERB
bjp-19065	125	17	m	m	PROPN
bjp-19065	125	18	,	,	PUNCT
bjp-19065	125	19	rautenberg	rautenberg	PROPN
bjp-19065	125	20	m	m	PROPN
bjp-19065	125	21	,	,	PUNCT
bjp-19065	125	22	vorgrimmler	vorgrimmler	NOUN
bjp-19065	125	23	d	d	PROPN
bjp-19065	125	24	,	,	PUNCT
bjp-19065	125	25	gebele	gebele	PROPN
bjp-19065	125	26	d	d	PROPN
bjp-19065	125	27	,	,	PUNCT
bjp-19065	125	28	helma	helma	PROPN
bjp-19065	125	29	c.	c.	PROPN
bjp-19065	125	30	lazar	lazar	PROPN
bjp-19065	125	31	:	:	PUNCT
bjp-19065	125	32	a	a	DET
bjp-19065	125	33	modular	modular	ADJ
bjp-19065	125	34	predictive	predictive	ADJ
bjp-19065	125	35	toxicology	toxicology	NOUN
bjp-19065	125	36	framework	framework	NOUN
bjp-19065	125	37	.	.	PUNCT
bjp-19065	126	1	front	front	ADJ
bjp-19065	126	2	pharmacol	pharmacol	PROPN
bjp-19065	126	3	.	.	PUNCT
bjp-19065	127	1	2013	2013	NUM
bjp-19065	127	2	;	;	PUNCT
bjp-19065	127	3	4	4	NUM
bjp-19065	127	4	:	:	SYM
bjp-19065	127	5	38	38	NUM
bjp-19065	127	6	.	.	PUNCT
bjp-19065	128	1	mcinnes	mcinne	NOUN
bjp-19065	128	2	ib	ib	PROPN
bjp-19065	128	3	,	,	PUNCT
bjp-19065	128	4	schett	schett	PROPN
bjp-19065	128	5	g.	g.	PROPN
bjp-19065	128	6	the	the	DET
bjp-19065	128	7	pathogenesis	pathogenesis	NOUN
bjp-19065	128	8	of	of	ADP
bjp-19065	128	9	rheumatoid	rheumatoid	NOUN
bjp-19065	128	10	arthritis	arthritis	NOUN
bjp-19065	128	11	.	.	PUNCT
bjp-19065	129	1	n	n	PROPN
bjp-19065	129	2	engl	engl	PROPN
bjp-19065	129	3	j	j	PROPN
bjp-19065	129	4	med	med	PROPN
bjp-19065	129	5	.	.	PUNCT
bjp-19065	129	6	2011	2011	NUM
bjp-19065	129	7	;	;	PUNCT
bjp-19065	129	8	365	365	NUM
bjp-19065	129	9	:	:	SYM
bjp-19065	129	10	2205	2205	NUM
bjp-19065	129	11	-	-	SYM
bjp-19065	129	12	19	19	NUM
bjp-19065	129	13	.	.	PUNCT
bjp-19065	130	1	morris	morris	PROPN
bjp-19065	130	2	gm1	gm1	PROPN
bjp-19065	130	3	,	,	PUNCT
bjp-19065	130	4	huey	huey	PROPN
bjp-19065	130	5	r	r	PROPN
bjp-19065	130	6	,	,	PUNCT
bjp-19065	130	7	lindstrom	lindstrom	PROPN
bjp-19065	130	8	w	w	PROPN
bjp-19065	130	9	,	,	PUNCT
bjp-19065	130	10	sanner	sanner	NOUN
bjp-19065	130	11	mf	mf	PROPN
bjp-19065	130	12	,	,	PUNCT
bjp-19065	130	13	belew	belew	NOUN
bjp-19065	130	14	rk	rk	PROPN
bjp-19065	130	15	,	,	PUNCT
bjp-19065	130	16	goodsell	goodsell	X
bjp-19065	130	17	ds	ds	PROPN
bjp-19065	130	18	,	,	PUNCT
bjp-19065	130	19	olson	olson	PROPN
bjp-19065	130	20	aj	aj	PROPN
bjp-19065	130	21	.	.	PROPN
bjp-19065	131	1	autodock4	autodock4	PROPN
bjp-19065	131	2	and	and	CCONJ
bjp-19065	131	3	autodock	autodock	NOUN
bjp-19065	131	4	tools	tool	NOUN
bjp-19065	131	5	4	4	NUM
bjp-19065	131	6	:	:	PUNCT
bjp-19065	131	7	automated	automate	VERB
bjp-19065	131	8	docking	docking	NOUN
bjp-19065	131	9	with	with	ADP
bjp-19065	131	10	selective	selective	ADJ
bjp-19065	131	11	receptor	receptor	NOUN
bjp-19065	131	12	flexibility	flexibility	NOUN
bjp-19065	131	13	.	.	PUNCT
bjp-19065	132	1	j	j	PROPN
bjp-19065	132	2	comput	comput	PROPN
bjp-19065	132	3	chem	chem	PROPN
bjp-19065	132	4	.	.	PUNCT
bjp-19065	133	1	2009	2009	NUM
bjp-19065	133	2	;	;	PUNCT
bjp-19065	133	3	30	30	NUM
bjp-19065	133	4	:	:	PUNCT
bjp-19065	133	5	2785	2785	NUM
bjp-19065	133	6	-	-	SYM
bjp-19065	133	7	91	91	NUM
bjp-19065	133	8	.	.	PUNCT
bjp-19065	134	1	scott	scott	PROPN
bjp-19065	134	2	dl	dl	PROPN
bjp-19065	134	3	,	,	PUNCT
bjp-19065	134	4	wolfe	wolfe	PROPN
bjp-19065	134	5	f	f	PROPN
bjp-19065	134	6	,	,	PUNCT
bjp-19065	134	7	huizinga	huizinga	PROPN
bjp-19065	134	8	tw	tw	INTJ
bjp-19065	134	9	.	.	PUNCT
bjp-19065	135	1	rheumatoid	rheumatoid	VERB
bjp-19065	135	2	arthritis	arthritis	NOUN
bjp-19065	135	3	.	.	PUNCT
bjp-19065	136	1	lancet	lancet	PROPN
bjp-19065	136	2	2010	2010	NUM
bjp-19065	136	3	;	;	PUNCT
bjp-19065	136	4	376	376	NUM
bjp-19065	136	5	:	:	PUNCT
bjp-19065	136	6	1094	1094	NUM
bjp-19065	136	7	-	-	SYM
bjp-19065	136	8	108	108	NUM
bjp-19065	136	9	.	.	PUNCT
bjp-19065	137	1	somers	somers	PROPN
bjp-19065	137	2	w	w	PROPN
bjp-19065	137	3	,	,	PUNCT
bjp-19065	137	4	stahl	stahl	PROPN
bjp-19065	137	5	m	m	PROPN
bjp-19065	137	6	,	,	PUNCT
bjp-19065	137	7	seehra	seehra	PROPN
bjp-19065	137	8	js	js	PROPN
bjp-19065	137	9	.	.	PROPN
bjp-19065	138	1	1.9	1.9	NUM
bjp-19065	138	2	a	a	DET
bjp-19065	138	3	crystal	crystal	NOUN
bjp-19065	138	4	structure	structure	NOUN
bjp-19065	138	5	of	of	ADP
bjp-19065	138	6	interleukin	interleukin	NOUN
bjp-19065	138	7	6	6	NUM
bjp-19065	138	8	:	:	PUNCT
bjp-19065	138	9	implications	implication	NOUN
bjp-19065	138	10	for	for	ADP
bjp-19065	138	11	a	a	DET
bjp-19065	138	12	novel	novel	ADJ
bjp-19065	138	13	mode	mode	NOUN
bjp-19065	138	14	of	of	ADP
bjp-19065	138	15	receptor	receptor	NOUN
bjp-19065	138	16	dimerization	dimerization	NOUN
bjp-19065	138	17	and	and	CCONJ
bjp-19065	138	18	signaling	signal	VERB
bjp-19065	138	19	.	.	PUNCT
bjp-19065	139	1	embo	embo	PROPN
bjp-19065	139	2	j.	j.	PROPN
bjp-19065	139	3	1997	1997	NUM
bjp-19065	139	4	;	;	PUNCT
bjp-19065	139	5	16	16	NUM
bjp-19065	139	6	:	:	SYM
bjp-19065	139	7	989	989	NUM
bjp-19065	139	8	-	-	SYM
bjp-19065	139	9	97	97	NUM
bjp-19065	139	10	.	.	PUNCT
bjp-19065	140	1	szekanecz	szekanecz	PROPN
bjp-19065	140	2	z	z	PROPN
bjp-19065	140	3	,	,	PUNCT
bjp-19065	140	4	besenyei	besenyei	PROPN
bjp-19065	140	5	t	t	PROPN
bjp-19065	140	6	,	,	PUNCT
bjp-19065	140	7	paragh	paragh	PROPN
bjp-19065	140	8	g	g	PROPN
bjp-19065	140	9	,	,	PUNCT
bjp-19065	140	10	koch	koch	PROPN
bjp-19065	140	11	ae	ae	PROPN
bjp-19065	140	12	.	.	PUNCT
bjp-19065	141	1	angiogenesis	angiogenesis	NOUN
bjp-19065	141	2	in	in	ADP
bjp-19065	141	3	rheumatoid	rheumatoid	NOUN
bjp-19065	141	4	arthritis	arthritis	NOUN
bjp-19065	141	5	.	.	PUNCT
bjp-19065	142	1	autoimmunity	autoimmunity	NOUN
bjp-19065	142	2	2009	2009	NUM
bjp-19065	142	3	;	;	PUNCT
bjp-19065	142	4	42	42	NUM
bjp-19065	142	5	:	:	PUNCT
bjp-19065	142	6	563	563	NUM
bjp-19065	142	7	-	-	SYM
bjp-19065	142	8	73	73	NUM
bjp-19065	142	9	.	.	PUNCT
bjp-19065	143	1	thompson	thompson	PROPN
bjp-19065	143	2	ma	ma	PROPN
bjp-19065	143	3	.	.	PROPN
bjp-19065	143	4	arguslab	arguslab	PROPN
bjp-19065	143	5	4.0	4.0	NUM
bjp-19065	143	6	.	.	NOUN
bjp-19065	143	7	1	1	NUM
bjp-19065	143	8	.	.	PUNCT
bjp-19065	143	9	planaria	planaria	PROPN
bjp-19065	143	10	software	software	PROPN
bjp-19065	143	11	llc	llc	PROPN
bjp-19065	143	12	,	,	PUNCT
bjp-19065	143	13	seattle	seattle	PROPN
bjp-19065	143	14	,	,	PUNCT
bjp-19065	143	15	wa	wa	PROPN
bjp-19065	143	16	,	,	PUNCT
bjp-19065	143	17	2004	2004	NUM
bjp-19065	143	18	.	.	PUNCT
bjp-19065	144	1	van	van	PROPN
bjp-19065	144	2	de	de	PROPN
bjp-19065	144	3	waterbeemd	waterbeemd	PROPN
bjp-19065	144	4	h	h	PROPN
bjp-19065	144	5	,	,	PUNCT
bjp-19065	144	6	camenisch	camenisch	VERB
bjp-19065	144	7	g	g	PROPN
bjp-19065	144	8	,	,	PUNCT
bjp-19065	144	9	folkers	folker	NOUN
bjp-19065	144	10	g	g	PROPN
bjp-19065	144	11	,	,	PUNCT
bjp-19065	144	12	chretien	chretien	PROPN
bjp-19065	144	13	jr	jr	PROPN
bjp-19065	144	14	,	,	PUNCT
bjp-19065	144	15	raevsky	raevsky	PROPN
bjp-19065	144	16	oa	oa	PROPN
bjp-19065	144	17	.	.	PUNCT
bjp-19065	144	18	estimation	estimation	NOUN
bjp-19065	144	19	of	of	ADP
bjp-19065	144	20	blood	blood	NOUN
bjp-19065	144	21	-	-	PUNCT
bjp-19065	144	22	brain	brain	NOUN
bjp-19065	144	23	barrier	barrier	NOUN
bjp-19065	144	24	crossing	crossing	NOUN
bjp-19065	144	25	of	of	ADP
bjp-19065	144	26	drugs	drug	NOUN
bjp-19065	144	27	using	use	VERB
bjp-19065	144	28	molecular	molecular	ADJ
bjp-19065	144	29	size	size	NOUN
bjp-19065	144	30	and	and	CCONJ
bjp-19065	144	31	shape	shape	NOUN
bjp-19065	144	32	,	,	PUNCT
bjp-19065	144	33	and	and	CCONJ
bjp-19065	144	34	h	h	NOUN
bjp-19065	144	35	-	-	PUNCT
bjp-19065	144	36	bonding	bond	VERB
bjp-19065	144	37	descriptors	descriptor	NOUN
bjp-19065	144	38	.	.	PUNCT
bjp-19065	145	1	j	j	PROPN
bjp-19065	145	2	drug	drug	NOUN
bjp-19065	145	3	target	target	NOUN
bjp-19065	145	4	.	.	PUNCT
bjp-19065	146	1	1998	1998	NUM
bjp-19065	146	2	;	;	PUNCT
bjp-19065	146	3	6	6	NUM
bjp-19065	146	4	:	:	SYM
bjp-19065	146	5	151	151	NUM
bjp-19065	146	6	-	-	SYM
bjp-19065	146	7	65	65	NUM
bjp-19065	146	8	.	.	PUNCT
bjp-19065	147	1	van	van	PROPN
bjp-19065	147	2	de	de	PROPN
bjp-19065	147	3	waterbeemd	waterbeemd	PROPN
bjp-19065	147	4	h	h	PROPN
bjp-19065	147	5	,	,	PUNCT
bjp-19065	147	6	gifford	gifford	PROPN
bjp-19065	147	7	e.	e.	PROPN
bjp-19065	147	8	admet	admet	PROPN
bjp-19065	147	9	in	in	ADP
bjp-19065	147	10	silico	silico	NOUN
bjp-19065	147	11	modelling	modelling	NOUN
bjp-19065	147	12	:	:	PUNCT
bjp-19065	147	13	towards	towards	ADP
bjp-19065	147	14	prediction	prediction	NOUN
bjp-19065	147	15	paradise	paradise	PROPN
bjp-19065	147	16	?	?	PUNCT
bjp-19065	148	1	nat	nat	PROPN
bjp-19065	148	2	rev	rev	VERB
bjp-19065	148	3	drug	drug	NOUN
bjp-19065	148	4	discov	discov	NOUN
bjp-19065	148	5	.	.	PUNCT
bjp-19065	149	1	2003	2003	NUM
bjp-19065	149	2	;	;	PUNCT
bjp-19065	149	3	2	2	NUM
bjp-19065	149	4	:	:	SYM
bjp-19065	149	5	192	192	NUM
bjp-19065	149	6	-	-	SYM
bjp-19065	149	7	204	204	NUM
bjp-19065	149	8	.	.	PUNCT
bjp-19065	150	1	zhao	zhao	PROPN
bjp-19065	150	2	yh	yh	PROPN
bjp-19065	150	3	,	,	PUNCT
bjp-19065	150	4	le	le	PROPN
bjp-19065	150	5	j	j	PROPN
bjp-19065	150	6	,	,	PUNCT
bjp-19065	150	7	abraham	abraham	PROPN
bjp-19065	150	8	mh	mh	PROPN
bjp-19065	150	9	,	,	PUNCT
bjp-19065	150	10	hersey	hersey	PROPN
bjp-19065	150	11	a	a	PRON
bjp-19065	150	12	,	,	PUNCT
bjp-19065	150	13	eddershaw	eddershaw	PROPN
bjp-19065	150	14	pj	pj	PROPN
bjp-19065	150	15	,	,	PUNCT
bjp-19065	150	16	luscombe	luscombe	NOUN
bjp-19065	150	17	cn	cn	PROPN
bjp-19065	150	18	,	,	PUNCT
bjp-19065	150	19	butina	butina	PROPN
bjp-19065	150	20	d	d	PROPN
bjp-19065	150	21	,	,	PUNCT
bjp-19065	150	22	beck	beck	PROPN
bjp-19065	150	23	g	g	PROPN
bjp-19065	150	24	,	,	PUNCT
bjp-19065	150	25	sherborne	sherborne	PROPN
bjp-19065	150	26	b	b	PROPN
bjp-19065	150	27	,	,	PUNCT
bjp-19065	150	28	cooper	cooper	PROPN
bjp-19065	150	29	i	i	PROPN
bjp-19065	150	30	,	,	PUNCT
bjp-19065	150	31	platts	platts	PROPN
bjp-19065	150	32	ja	ja	PROPN
bjp-19065	150	33	.	.	PUNCT
bjp-19065	150	34	evaluation	evaluation	NOUN
bjp-19065	150	35	of	of	ADP
bjp-19065	150	36	human	human	ADJ
bjp-19065	150	37	intestinal	intestinal	ADJ
bjp-19065	150	38	absorption	absorption	NOUN
bjp-19065	150	39	data	datum	NOUN
bjp-19065	150	40	and	and	CCONJ
bjp-19065	150	41	subsequent	subsequent	ADJ
bjp-19065	150	42	derivation	derivation	NOUN
bjp-19065	150	43	of	of	ADP
bjp-19065	150	44	a	a	DET
bjp-19065	150	45	quantitative	quantitative	ADJ
bjp-19065	150	46	structureactivity	structureactivity	NOUN
bjp-19065	150	47	relationship	relationship	NOUN
bjp-19065	150	48	(	(	PUNCT
bjp-19065	150	49	qsar	qsar	NOUN
bjp-19065	150	50	)	)	PUNCT
bjp-19065	150	51	with	with	ADP
bjp-19065	150	52	the	the	DET
bjp-19065	150	53	abraham	abraham	PROPN
bjp-19065	150	54	descriptors	descriptor	NOUN
bjp-19065	150	55	.	.	PUNCT
bjp-19065	151	1	j	j	PROPN
bjp-19065	151	2	pharm	pharm	PROPN
bjp-19065	151	3	sci	sci	PROPN
bjp-19065	151	4	.	.	PROPN
bjp-19065	151	5	2001	2001	NUM
bjp-19065	151	6	;	;	PUNCT
bjp-19065	151	7	90	90	NUM
bjp-19065	151	8	:	:	PUNCT
bjp-19065	151	9	749	749	NUM
bjp-19065	151	10	-	-	SYM
bjp-19065	151	11	84	84	NUM
bjp-19065	151	12	.	.	PUNCT
bjp-19065	152	1	zhou	zhou	PROPN
bjp-19065	152	2	l	l	PROPN
bjp-19065	152	3	,	,	PUNCT
bjp-19065	152	4	ivanov	ivanov	PROPN
bjp-19065	152	5	ii	ii	PROPN
bjp-19065	152	6	,	,	PUNCT
bjp-19065	152	7	spolski	spolski	NOUN
bjp-19065	152	8	r	r	NOUN
bjp-19065	152	9	,	,	PUNCT
bjp-19065	152	10	min	min	NOUN
bjp-19065	152	11	r	r	NOUN
bjp-19065	152	12	,	,	PUNCT
bjp-19065	152	13	shenderov	shenderov	NOUN
bjp-19065	152	14	k	k	PROPN
bjp-19065	152	15	,	,	PUNCT
bjp-19065	152	16	egawa	egawa	PROPN
bjp-19065	152	17	t	t	PROPN
bjp-19065	152	18	,	,	PUNCT
bjp-19065	152	19	levy	levy	NOUN
bjp-19065	152	20	de	de	PROPN
bjp-19065	152	21	,	,	PUNCT
bjp-19065	152	22	leonard	leonard	PROPN
bjp-19065	152	23	wj	wj	PROPN
bjp-19065	152	24	,	,	PUNCT
bjp-19065	152	25	littman	littman	PROPN
bjp-19065	152	26	dr	dr	PROPN
bjp-19065	152	27	.	.	PROPN
bjp-19065	152	28	il-6	il-6	NOUN
bjp-19065	152	29	programs	program	NOUN
bjp-19065	152	30	t(h)17	t(h)17	CCONJ
bjp-19065	152	31	cell	cell	NOUN
bjp-19065	152	32	differentiation	differentiation	NOUN
bjp-19065	152	33	by	by	ADP
bjp-19065	152	34	promoting	promote	VERB
bjp-19065	152	35	sequential	sequential	ADJ
bjp-19065	152	36	engagement	engagement	NOUN
bjp-19065	152	37	of	of	ADP
bjp-19065	152	38	the	the	DET
bjp-19065	152	39	il-21	il-21	ADJ
bjp-19065	152	40	and	and	CCONJ
bjp-19065	152	41	il-23	il-23	NOUN
bjp-19065	152	42	pathways	pathway	NOUN
bjp-19065	152	43	.	.	PUNCT
bjp-19065	153	1	nat	nat	PROPN
bjp-19065	153	2	immunol	immunol	NOUN
bjp-19065	153	3	.	.	PUNCT
bjp-19065	154	1	2007	2007	NUM
bjp-19065	154	2	;	;	PUNCT
bjp-19065	154	3	8	8	NUM
bjp-19065	154	4	:	:	SYM
bjp-19065	154	5	96774	96774	NUM
bjp-19065	154	6	.	.	PUNCT
bjp-19065	155	1	376	376	NUM
bjp-19065	155	2	bangladesh	bangladesh	PROPN
bjp-19065	155	3	j	j	PROPN
bjp-19065	155	4	pharmacol	pharmacol	PROPN
bjp-19065	155	5	2014	2014	NUM
bjp-19065	155	6	;	;	PUNCT
bjp-19065	155	7	9	9	NUM
bjp-19065	155	8	:	:	SYM
bjp-19065	155	9	371	371	NUM
bjp-19065	155	10	-	-	SYM
bjp-19065	155	11	376	376	NUM
bjp-19065	155	12	author	author	NOUN
bjp-19065	155	13	info	info	NOUN
bjp-19065	155	14	feng	feng	PROPN
bjp-19065	155	15	yin	yin	PROPN
bjp-19065	155	16	(	(	PUNCT
bjp-19065	155	17	principal	principal	ADJ
bjp-19065	155	18	contact	contact	NOUN
bjp-19065	155	19	)	)	PUNCT
bjp-19065	155	20	e	e	NOUN
bjp-19065	155	21	-	-	NOUN
bjp-19065	155	22	mail	mail	NOUN
bjp-19065	155	23	:	:	PUNCT
bjp-19065	155	24	yinfeng6226@gmail.com	yinfeng6226@gmail.com	X
bjp-19065	155	25	mailto:yinfeng6226@gmail.com	mailto:yinfeng6226@gmail.com	PROPN
bjp-19065	155	26	dateprinted	dateprinte	VERB
bjp-19065	155	27	:	:	PUNCT
bjp-19065	155	28	this	this	DET
bjp-19065	155	29	article	article	NOUN
bjp-19065	155	30	was	be	AUX
bjp-19065	155	31	downloaded	download	VERB
bjp-19065	155	32	by	by	ADP
bjp-19065	155	33	you	you	PRON
bjp-19065	155	34	on	on	ADP
bjp-19065	155	35	:	:	PUNCT
bjp-19065	155	36	jul	jul	PROPN
bjp-19065	155	37	29	29	NUM
bjp-19065	155	38	,	,	PUNCT
bjp-19065	155	39	2018	2018	NUM