id	sid	tid	token	lemma	pos
bjp-19568	1	1	bangladesh	bangladesh	PROPN
bjp-19568	1	2	journal	journal	PROPN
bjp-19568	1	3	of	of	ADP
bjp-19568	1	4	pharmacology	pharmacology	NOUN
bjp-19568	1	5	research	research	NOUN
bjp-19568	1	6	article	article	NOUN
bjp-19568	1	7	withaferin	withaferin	VERB
bjp-19568	1	8	a	a	DET
bjp-19568	1	9	inhibits	inhibit	VERB
bjp-19568	1	10	osteosarcoma	osteosarcoma	ADJ
bjp-19568	1	11	cells	cell	NOUN
bjp-19568	1	12	through	through	ADP
bjp-19568	1	13	inactivation	inactivation	NOUN
bjp-19568	1	14	of	of	ADP
bjp-19568	1	15	notch-1	notch-1	NUM
bjp-19568	1	16	signaling	signal	VERB
bjp-19568	1	17	bjp	bjp	NOUN
bjp-19568	1	18	introduction	introduction	NOUN
bjp-19568	1	19	osteosarcoma	osteosarcoma	NOUN
bjp-19568	1	20	,	,	PUNCT
bjp-19568	1	21	a	a	DET
bjp-19568	1	22	primary	primary	ADJ
bjp-19568	1	23	malignancy	malignancy	NOUN
bjp-19568	1	24	which	which	PRON
bjp-19568	1	25	predominantly	predominantly	ADV
bjp-19568	1	26	affects	affect	VERB
bjp-19568	1	27	rapidly	rapidly	ADV
bjp-19568	1	28	growing	grow	VERB
bjp-19568	1	29	bones	bone	NOUN
bjp-19568	1	30	in	in	ADP
bjp-19568	1	31	adolescents	adolescent	NOUN
bjp-19568	1	32	and	and	CCONJ
bjp-19568	1	33	children	child	NOUN
bjp-19568	1	34	,	,	PUNCT
bjp-19568	1	35	is	be	AUX
bjp-19568	1	36	characterized	characterize	VERB
bjp-19568	1	37	by	by	ADP
bjp-19568	1	38	locally	locally	ADV
bjp-19568	1	39	aggressive	aggressive	ADJ
bjp-19568	1	40	growth	growth	NOUN
bjp-19568	1	41	and	and	CCONJ
bjp-19568	1	42	early	early	ADJ
bjp-19568	1	43	metastatic	metastatic	ADJ
bjp-19568	1	44	potential	potential	NOUN
bjp-19568	1	45	(	(	PUNCT
bjp-19568	1	46	arndt	arndt	PROPN
bjp-19568	1	47	and	and	CCONJ
bjp-19568	1	48	crist	crist	PROPN
bjp-19568	1	49	,	,	PUNCT
bjp-19568	1	50	1999	1999	NUM
bjp-19568	1	51	)	)	PUNCT
bjp-19568	1	52	.	.	PUNCT
bjp-19568	2	1	despite	despite	SCONJ
bjp-19568	2	2	significant	significant	ADJ
bjp-19568	2	3	clinical	clinical	ADJ
bjp-19568	2	4	improvements	improvement	NOUN
bjp-19568	2	5	through	through	ADP
bjp-19568	2	6	the	the	DET
bjp-19568	2	7	use	use	NOUN
bjp-19568	2	8	of	of	ADP
bjp-19568	2	9	combination	combination	NOUN
bjp-19568	2	10	intensive	intensive	ADJ
bjp-19568	2	11	chemotherapy	chemotherapy	NOUN
bjp-19568	2	12	and	and	CCONJ
bjp-19568	2	13	surgical	surgical	ADJ
bjp-19568	2	14	resection	resection	NOUN
bjp-19568	2	15	,	,	PUNCT
bjp-19568	2	16	respiratory	respiratory	ADJ
bjp-19568	2	17	failures	failure	NOUN
bjp-19568	2	18	due	due	ADJ
bjp-19568	2	19	to	to	ADP
bjp-19568	2	20	lung	lung	NOUN
bjp-19568	2	21	metastases	metastasis	NOUN
bjp-19568	2	22	are	be	AUX
bjp-19568	2	23	common	common	ADJ
bjp-19568	2	24	events	event	NOUN
bjp-19568	2	25	and	and	CCONJ
bjp-19568	2	26	the	the	DET
bjp-19568	2	27	major	major	ADJ
bjp-19568	2	28	cause	cause	NOUN
bjp-19568	2	29	of	of	ADP
bjp-19568	2	30	death	death	NOUN
bjp-19568	2	31	in	in	ADP
bjp-19568	2	32	these	these	DET
bjp-19568	2	33	patients	patient	NOUN
bjp-19568	2	34	(	(	PUNCT
bjp-19568	2	35	petrilli	petrilli	NOUN
bjp-19568	2	36	et	et	PROPN
bjp-19568	2	37	al	al	PROPN
bjp-19568	2	38	.	.	PROPN
bjp-19568	2	39	,	,	PUNCT
bjp-19568	2	40	2006	2006	NUM
bjp-19568	2	41	;	;	PUNCT
bjp-19568	2	42	bielack	bielack	NOUN
bjp-19568	2	43	et	et	PROPN
bjp-19568	2	44	al	al	PROPN
bjp-19568	2	45	.	.	PROPN
bjp-19568	2	46	,	,	PUNCT
bjp-19568	2	47	2002	2002	NUM
bjp-19568	2	48	)	)	PUNCT
bjp-19568	2	49	.	.	PUNCT
bjp-19568	3	1	moreover	moreover	ADV
bjp-19568	3	2	,	,	PUNCT
bjp-19568	3	3	effective	effective	ADJ
bjp-19568	3	4	therapeutic	therapeutic	ADJ
bjp-19568	3	5	options	option	NOUN
bjp-19568	3	6	available	available	ADJ
bjp-19568	3	7	for	for	ADP
bjp-19568	3	8	patients	patient	NOUN
bjp-19568	3	9	who	who	PRON
bjp-19568	3	10	either	either	CCONJ
bjp-19568	3	11	relapse	relapse	VERB
bjp-19568	3	12	following	follow	VERB
bjp-19568	3	13	administration	administration	NOUN
bjp-19568	3	14	of	of	ADP
bjp-19568	3	15	currently	currently	ADV
bjp-19568	3	16	approved	approve	VERB
bjp-19568	3	17	chemotherapeutic	chemotherapeutic	ADJ
bjp-19568	3	18	agents	agent	NOUN
bjp-19568	3	19	or	or	CCONJ
bjp-19568	3	20	suffer	suffer	VERB
bjp-19568	3	21	intolerable	intolerable	ADJ
bjp-19568	3	22	acute	acute	ADJ
bjp-19568	3	23	and	and	CCONJ
bjp-19568	3	24	long	long	ADJ
bjp-19568	3	25	term	term	NOUN
bjp-19568	3	26	toxicities	toxicity	NOUN
bjp-19568	3	27	from	from	ADP
bjp-19568	3	28	chemotherapy	chemotherapy	NOUN
bjp-19568	3	29	treatments	treatment	NOUN
bjp-19568	3	30	are	be	AUX
bjp-19568	3	31	seriously	seriously	ADV
bjp-19568	3	32	lacking	lacking	ADJ
bjp-19568	3	33	.	.	PUNCT
bjp-19568	4	1	therefore	therefore	ADV
bjp-19568	4	2	,	,	PUNCT
bjp-19568	4	3	more	more	ADV
bjp-19568	4	4	effective	effective	ADJ
bjp-19568	4	5	treatment	treatment	NOUN
bjp-19568	4	6	strategies	strategy	NOUN
bjp-19568	4	7	are	be	AUX
bjp-19568	4	8	urgently	urgently	ADV
bjp-19568	4	9	needed	need	VERB
bjp-19568	4	10	to	to	PART
bjp-19568	4	11	prevent	prevent	VERB
bjp-19568	4	12	osteosarcoma	osteosarcoma	ADJ
bjp-19568	4	13	disease	disease	NOUN
bjp-19568	4	14	progression	progression	NOUN
bjp-19568	4	15	and	and	CCONJ
bjp-19568	4	16	improve	improve	VERB
bjp-19568	4	17	patient	patient	ADJ
bjp-19568	4	18	survival	survival	NOUN
bjp-19568	4	19	rates	rate	NOUN
bjp-19568	4	20	.	.	PUNCT
bjp-19568	5	1	it	it	PRON
bjp-19568	5	2	is	be	AUX
bjp-19568	5	3	well	well	ADV
bjp-19568	5	4	established	establish	VERB
bjp-19568	5	5	that	that	SCONJ
bjp-19568	5	6	various	various	ADJ
bjp-19568	5	7	compounds	compound	NOUN
bjp-19568	5	8	of	of	ADP
bjp-19568	5	9	withania	withania	NOUN
bjp-19568	5	10	species	specie	NOUN
bjp-19568	5	11	,	,	PUNCT
bjp-19568	5	12	such	such	ADJ
bjp-19568	5	13	as	as	ADP
bjp-19568	5	14	withaferin	withaferin	NOUN
bjp-19568	5	15	a	a	NOUN
bjp-19568	5	16	from	from	ADP
bjp-19568	5	17	the	the	DET
bjp-19568	5	18	leaves	leave	NOUN
bjp-19568	5	19	(	(	PUNCT
bjp-19568	5	20	jayaprakasam	jayaprakasam	PROPN
bjp-19568	5	21	et	et	PROPN
bjp-19568	5	22	al	al	PROPN
bjp-19568	5	23	.	.	PROPN
bjp-19568	5	24	,	,	PUNCT
bjp-19568	5	25	2003	2003	NUM
bjp-19568	5	26	)	)	PUNCT
bjp-19568	5	27	,	,	PUNCT
bjp-19568	5	28	and	and	CCONJ
bjp-19568	5	29	ashwagandhanolides	ashwagandhanolide	NOUN
bjp-19568	5	30	from	from	ADP
bjp-19568	5	31	the	the	DET
bjp-19568	5	32	roots	root	NOUN
bjp-19568	5	33	of	of	ADP
bjp-19568	5	34	w.	w.	PROPN
bjp-19568	5	35	somnifera	somnifera	PROPN
bjp-19568	5	36	(	(	PUNCT
bjp-19568	5	37	subbaraju	subbaraju	NOUN
bjp-19568	5	38	et	et	PROPN
bjp-19568	5	39	al	al	PROPN
bjp-19568	5	40	.	.	PROPN
bjp-19568	5	41	,	,	PUNCT
bjp-19568	5	42	2006	2006	NUM
bjp-19568	5	43	)	)	PUNCT
bjp-19568	5	44	are	be	AUX
bjp-19568	5	45	known	know	VERB
bjp-19568	5	46	to	to	PART
bjp-19568	5	47	possess	possess	VERB
bjp-19568	5	48	anti	anti	ADJ
bjp-19568	5	49	-	-	ADJ
bjp-19568	5	50	cancer	cancer	ADJ
bjp-19568	5	51	properties	property	NOUN
bjp-19568	5	52	.	.	PUNCT
bjp-19568	6	1	the	the	DET
bjp-19568	6	2	mechanism	mechanism	NOUN
bjp-19568	6	3	by	by	ADP
bjp-19568	6	4	which	which	PRON
bjp-19568	6	5	withanolides	withanolide	NOUN
bjp-19568	6	6	demonstrate	demonstrate	VERB
bjp-19568	6	7	antiproliferative	antiproliferative	NOUN
bjp-19568	6	8	,	,	PUNCT
bjp-19568	6	9	antimetastatic	antimetastatic	ADJ
bjp-19568	6	10	,	,	PUNCT
bjp-19568	6	11	antiangiogenic	antiangiogenic	ADJ
bjp-19568	6	12	,	,	PUNCT
bjp-19568	6	13	anti	anti	ADJ
bjp-19568	6	14	-	-	ADJ
bjp-19568	6	15	invasive	invasive	ADJ
bjp-19568	6	16	,	,	PUNCT
bjp-19568	6	17	and	and	CCONJ
bjp-19568	6	18	proapoptotic	proapoptotic	ADJ
bjp-19568	6	19	activities	activity	NOUN
bjp-19568	6	20	has	have	AUX
bjp-19568	6	21	been	be	AUX
bjp-19568	6	22	associated	associate	VERB
bjp-19568	6	23	with	with	ADP
bjp-19568	6	24	the	the	DET
bjp-19568	6	25	suppression	suppression	NOUN
bjp-19568	6	26	of	of	ADP
bjp-19568	6	27	nf	nf	NOUN
bjp-19568	6	28	-	-	PUNCT
bjp-19568	6	29	jb	jb	PROPN
bjp-19568	6	30	and	and	CCONJ
bjp-19568	6	31	nf	nf	PROPN
bjp-19568	6	32	-	-	PUNCT
bjp-19568	6	33	jb	jb	NOUN
bjp-19568	6	34	-	-	PUNCT
bjp-19568	6	35	regulated	regulate	VERB
bjp-19568	6	36	gene	gene	NOUN
bjp-19568	6	37	products	product	NOUN
bjp-19568	6	38	(	(	PUNCT
bjp-19568	6	39	ichikawa	ichikawa	PROPN
bjp-19568	6	40	et	et	PROPN
bjp-19568	6	41	al	al	PROPN
bjp-19568	6	42	.	.	PROPN
bjp-19568	6	43	,	,	PUNCT
bjp-19568	6	44	2006	2006	NUM
bjp-19568	6	45	)	)	PUNCT
bjp-19568	6	46	.	.	PUNCT
bjp-19568	7	1	it	it	PRON
bjp-19568	7	2	was	be	AUX
bjp-19568	7	3	shown	show	VERB
bjp-19568	7	4	that	that	SCONJ
bjp-19568	7	5	wa	wa	PROPN
bjp-19568	7	6	inhibits	inhibit	VERB
bjp-19568	7	7	nuclear	nuclear	ADJ
bjp-19568	7	8	factor	factor	NOUN
bjp-19568	7	9	-	-	PUNCT
bjp-19568	7	10	kb	kb	PROPN
bjp-19568	7	11	(	(	PUNCT
bjp-19568	7	12	nf	nf	PROPN
bjp-19568	7	13	-	-	PUNCT
bjp-19568	7	14	kb	kb	NOUN
bjp-19568	7	15	)	)	PUNCT
bjp-19568	7	16	activation	activation	NOUN
bjp-19568	7	17	and	and	CCONJ
bjp-19568	7	18	induces	induce	VERB
bjp-19568	7	19	apoptosis	apoptosis	NOUN
bjp-19568	7	20	in	in	ADP
bjp-19568	7	21	prostate	prostate	NOUN
bjp-19568	7	22	cancer	cancer	NOUN
bjp-19568	7	23	cells	cell	NOUN
bjp-19568	7	24	through	through	ADP
bjp-19568	7	25	par-4	par-4	ADJ
bjp-19568	7	26	induction	induction	NOUN
bjp-19568	7	27	(	(	PUNCT
bjp-19568	7	28	srinivasan	srinivasan	NOUN
bjp-19568	7	29	et	et	PROPN
bjp-19568	7	30	al	al	PROPN
bjp-19568	7	31	.	.	PROPN
bjp-19568	7	32	2007	2007	NUM
bjp-19568	7	33	)	)	PUNCT
bjp-19568	7	34	,	,	PUNCT
bjp-19568	7	35	inhibits	inhibit	VERB
bjp-19568	7	36	ikb	ikb	PROPN
bjp-19568	7	37	kinase	kinase	PROPN
bjp-19568	7	38	activation	activation	NOUN
bjp-19568	7	39	via	via	ADP
bjp-19568	7	40	a	a	DET
bjp-19568	7	41	thioalkylation	thioalkylation	NOUN
bjp-19568	7	42	-	-	PUNCT
bjp-19568	7	43	sensitive	sensitive	ADJ
bjp-19568	7	44	redox	redox	ADJ
bjp-19568	7	45	mechanism	mechanism	NOUN
bjp-19568	7	46	(	(	PUNCT
bjp-19568	7	47	kaileh	kaileh	NOUN
bjp-19568	7	48	et	et	PROPN
bjp-19568	7	49	al	al	PROPN
bjp-19568	7	50	.	.	PROPN
bjp-19568	7	51	,	,	PUNCT
bjp-19568	7	52	2007	2007	NUM
bjp-19568	7	53	)	)	PUNCT
bjp-19568	7	54	.	.	PUNCT
bjp-19568	8	1	the	the	DET
bjp-19568	8	2	notch	notch	NOUN
bjp-19568	8	3	signaling	signal	VERB
bjp-19568	8	4	pathway	pathway	NOUN
bjp-19568	8	5	plays	play	VERB
bjp-19568	8	6	a	a	DET
bjp-19568	8	7	pivotal	pivotal	ADJ
bjp-19568	8	8	role	role	NOUN
bjp-19568	8	9	in	in	ADP
bjp-19568	8	10	fundamental	fundamental	ADJ
bjp-19568	8	11	processes	process	NOUN
bjp-19568	8	12	of	of	ADP
bjp-19568	8	13	cell	cell	NOUN
bjp-19568	8	14	-	-	PUNCT
bjp-19568	8	15	fate	fate	NOUN
bjp-19568	8	16	determination	determination	NOUN
bjp-19568	8	17	,	,	PUNCT
bjp-19568	8	18	including	include	VERB
bjp-19568	8	19	stem	stem	NOUN
bjp-19568	8	20	cell	cell	NOUN
bjp-19568	8	21	maintenance	maintenance	NOUN
bjp-19568	8	22	,	,	PUNCT
bjp-19568	8	23	differentiation	differentiation	NOUN
bjp-19568	8	24	,	,	PUNCT
bjp-19568	8	25	proliferation	proliferation	NOUN
bjp-19568	8	26	and	and	CCONJ
bjp-19568	8	27	apoptosis	apoptosis	NOUN
bjp-19568	8	28	(	(	PUNCT
bjp-19568	8	29	li	li	PROPN
bjp-19568	8	30	and	and	CCONJ
bjp-19568	8	31	harris	harris	PROPN
bjp-19568	8	32	,	,	PUNCT
bjp-19568	8	33	2005	2005	NUM
bjp-19568	8	34	)	)	PUNCT
bjp-19568	8	35	,	,	PUNCT
bjp-19568	8	36	and	and	CCONJ
bjp-19568	8	37	thereby	thereby	ADV
bjp-19568	8	38	may	may	AUX
bjp-19568	8	39	contribute	contribute	VERB
bjp-19568	8	40	to	to	ADP
bjp-19568	8	41	the	the	DET
bjp-19568	8	42	carcinogenesis	carcinogenesis	NOUN
bjp-19568	8	43	of	of	ADP
bjp-19568	8	44	osteosarcoma	osteosarcoma	NOUN
bjp-19568	8	45	.	.	PUNCT
bjp-19568	9	1	deregulated	deregulate	VERB
bjp-19568	9	2	notch	notch	ADJ
bjp-19568	9	3	receptor	receptor	NOUN
bjp-19568	9	4	expression	expression	NOUN
bjp-19568	9	5	has	have	AUX
bjp-19568	9	6	been	be	AUX
bjp-19568	9	7	reported	report	VERB
bjp-19568	9	8	in	in	ADP
bjp-19568	9	9	a	a	DET
bjp-19568	9	10	growing	grow	VERB
bjp-19568	9	11	number	number	NOUN
bjp-19568	9	12	of	of	ADP
bjp-19568	9	13	solid	solid	ADJ
bjp-19568	9	14	human	human	ADJ
bjp-19568	9	15	tumors	tumor	NOUN
bjp-19568	9	16	(	(	PUNCT
bjp-19568	9	17	leong	leong	PROPN
bjp-19568	9	18	and	and	CCONJ
bjp-19568	9	19	karsan	karsan	NOUN
bjp-19568	9	20	,	,	PUNCT
bjp-19568	9	21	2006	2006	NUM
bjp-19568	9	22	)	)	PUNCT
bjp-19568	9	23	,	,	PUNCT
bjp-19568	9	24	such	such	ADJ
bjp-19568	9	25	as	as	ADP
bjp-19568	9	26	pancreas	pancrea	NOUN
bjp-19568	9	27	(	(	PUNCT
bjp-19568	9	28	wang	wang	PROPN
bjp-19568	9	29	et	et	PROPN
bjp-19568	9	30	al	al	PROPN
bjp-19568	9	31	.	.	PROPN
bjp-19568	9	32	,	,	PUNCT
bjp-19568	9	33	2006	2006	NUM
bjp-19568	9	34	)	)	PUNCT
bjp-19568	9	35	,	,	PUNCT
bjp-19568	9	36	a	a	DET
bjp-19568	9	37	journal	journal	NOUN
bjp-19568	9	38	of	of	ADP
bjp-19568	9	39	the	the	DET
bjp-19568	9	40	bangladesh	bangladesh	NOUN
bjp-19568	9	41	pharmacological	pharmacological	ADJ
bjp-19568	9	42	society	society	NOUN
bjp-19568	9	43	(	(	PUNCT
bjp-19568	9	44	bdps	bdps	NOUN
bjp-19568	9	45	)	)	PUNCT
bjp-19568	9	46	bangladesh	bangladesh	PROPN
bjp-19568	9	47	j	j	PROPN
bjp-19568	9	48	pharmacol	pharmacol	PROPN
bjp-19568	9	49	2014	2014	NUM
bjp-19568	9	50	;	;	PUNCT
bjp-19568	9	51	9	9	NUM
bjp-19568	9	52	:	:	SYM
bjp-19568	9	53	364	364	NUM
bjp-19568	9	54	-	-	SYM
bjp-19568	9	55	370	370	NUM
bjp-19568	9	56	journal	journal	NOUN
bjp-19568	9	57	homepage	homepage	NOUN
bjp-19568	9	58	:	:	PUNCT
bjp-19568	9	59	www.banglajol.info	www.banglajol.info	PROPN
bjp-19568	9	60	abstracted	abstract	VERB
bjp-19568	9	61	/	/	SYM
bjp-19568	9	62	indexed	index	VERB
bjp-19568	9	63	in	in	ADP
bjp-19568	9	64	academic	academic	ADJ
bjp-19568	9	65	search	search	NOUN
bjp-19568	9	66	complete	complete	ADJ
bjp-19568	9	67	,	,	PUNCT
bjp-19568	9	68	agroforestry	agroforestry	NOUN
bjp-19568	9	69	abstracts	abstract	NOUN
bjp-19568	9	70	,	,	PUNCT
bjp-19568	9	71	asia	asia	PROPN
bjp-19568	9	72	journals	journal	NOUN
bjp-19568	9	73	online	online	ADV
bjp-19568	9	74	,	,	PUNCT
bjp-19568	9	75	bangladesh	bangladesh	NOUN
bjp-19568	9	76	journals	journal	NOUN
bjp-19568	9	77	online	online	ADV
bjp-19568	9	78	,	,	PUNCT
bjp-19568	9	79	biological	biological	ADJ
bjp-19568	9	80	abstracts	abstract	NOUN
bjp-19568	9	81	,	,	PUNCT
bjp-19568	9	82	biosis	biosis	NOUN
bjp-19568	9	83	previews	preview	NOUN
bjp-19568	9	84	,	,	PUNCT
bjp-19568	9	85	cab	cab	NOUN
bjp-19568	9	86	abstracts	abstract	NOUN
bjp-19568	9	87	,	,	PUNCT
bjp-19568	9	88	current	current	ADJ
bjp-19568	9	89	abstracts	abstract	NOUN
bjp-19568	9	90	,	,	PUNCT
bjp-19568	9	91	directory	directory	NOUN
bjp-19568	9	92	of	of	ADP
bjp-19568	9	93	open	open	ADJ
bjp-19568	9	94	access	access	NOUN
bjp-19568	9	95	journals	journal	NOUN
bjp-19568	9	96	,	,	PUNCT
bjp-19568	9	97	embase	embase	NOUN
bjp-19568	9	98	/	/	SYM
bjp-19568	9	99	excerpta	excerpta	NOUN
bjp-19568	9	100	medica	medica	NOUN
bjp-19568	9	101	,	,	PUNCT
bjp-19568	9	102	global	global	ADJ
bjp-19568	9	103	health	health	NOUN
bjp-19568	9	104	,	,	PUNCT
bjp-19568	9	105	google	google	PROPN
bjp-19568	9	106	scholar	scholar	NOUN
bjp-19568	9	107	,	,	PUNCT
bjp-19568	9	108	hinari	hinari	X
bjp-19568	9	109	(	(	PUNCT
bjp-19568	9	110	who	who	PRON
bjp-19568	9	111	)	)	PUNCT
bjp-19568	9	112	,	,	PUNCT
bjp-19568	9	113	international	international	ADJ
bjp-19568	9	114	pharmaceutical	pharmaceutical	ADJ
bjp-19568	9	115	abstracts	abstract	NOUN
bjp-19568	9	116	,	,	PUNCT
bjp-19568	9	117	open	open	ADJ
bjp-19568	9	118	j	j	PROPN
bjp-19568	9	119	-	-	PUNCT
bjp-19568	9	120	gate	gate	NOUN
bjp-19568	9	121	,	,	PUNCT
bjp-19568	9	122	science	science	NOUN
bjp-19568	9	123	citation	citation	NOUN
bjp-19568	9	124	index	index	NOUN
bjp-19568	9	125	expanded	expand	VERB
bjp-19568	9	126	,	,	PUNCT
bjp-19568	9	127	scopus	scopus	NOUN
bjp-19568	9	128	and	and	CCONJ
bjp-19568	9	129	social	social	ADJ
bjp-19568	9	130	sciences	sciences	PROPN
bjp-19568	9	131	citation	citation	NOUN
bjp-19568	9	132	index	index	NOUN
bjp-19568	9	133	issn	issn	PROPN
bjp-19568	9	134	:	:	PUNCT
bjp-19568	9	135	1991	1991	NUM
bjp-19568	9	136	-	-	PUNCT
bjp-19568	9	137	0088	0088	NUM
bjp-19568	9	138	abstract	abstract	ADJ
bjp-19568	9	139	human	human	ADJ
bjp-19568	9	140	osteosarcoma	osteosarcoma	ADJ
bjp-19568	9	141	cells	cell	NOUN
bjp-19568	9	142	were	be	AUX
bjp-19568	9	143	treated	treat	VERB
bjp-19568	9	144	with	with	ADP
bjp-19568	9	145	withaferin	withaferin	PROPN
bjp-19568	9	146	a	a	PROPN
bjp-19568	9	147	and	and	CCONJ
bjp-19568	9	148	the	the	DET
bjp-19568	9	149	antiproliferative	antiproliferative	ADJ
bjp-19568	9	150	activity	activity	NOUN
bjp-19568	9	151	was	be	AUX
bjp-19568	9	152	evaluated	evaluate	VERB
bjp-19568	9	153	by	by	ADP
bjp-19568	9	154	the	the	DET
bjp-19568	9	155	3-(4	3-(4	PROPN
bjp-19568	9	156	,	,	PUNCT
bjp-19568	9	157	5	5	NUM
bjp-19568	9	158	dimethyl	dimethyl	NOUN
bjp-19568	9	159	-	-	PUNCT
bjp-19568	9	160	thiazol-2	thiazol-2	PROPN
bjp-19568	9	161	-	-	PUNCT
bjp-19568	9	162	yl)-2	yl)-2	NOUN
bjp-19568	9	163	,	,	PUNCT
bjp-19568	9	164	5diphenyltetrazolium	5diphenyltetrazolium	NUM
bjp-19568	9	165	bromide	bromide	NOUN
bjp-19568	9	166	(	(	PUNCT
bjp-19568	9	167	mtt	mtt	NOUN
bjp-19568	9	168	)	)	PUNCT
bjp-19568	9	169	assays	assay	NOUN
bjp-19568	9	170	.	.	PUNCT
bjp-19568	10	1	real	real	ADJ
bjp-19568	10	2	-	-	PUNCT
bjp-19568	10	3	time	time	NOUN
bjp-19568	10	4	rt	rt	NOUN
bjp-19568	10	5	-	-	PUNCT
bjp-19568	10	6	pcr	pcr	ADJ
bjp-19568	10	7	and	and	CCONJ
bjp-19568	10	8	western	western	ADJ
bjp-19568	10	9	blot	blot	NOUN
bjp-19568	10	10	were	be	AUX
bjp-19568	10	11	used	use	VERB
bjp-19568	10	12	to	to	PART
bjp-19568	10	13	investigate	investigate	VERB
bjp-19568	10	14	whether	whether	SCONJ
bjp-19568	10	15	the	the	DET
bjp-19568	10	16	down	down	NOUN
bjp-19568	10	17	-	-	PUNCT
bjp-19568	10	18	regulation	regulation	NOUN
bjp-19568	10	19	of	of	ADP
bjp-19568	10	20	notch-1	notch-1	NUM
bjp-19568	10	21	contributes	contribute	VERB
bjp-19568	10	22	to	to	PART
bjp-19568	10	23	withaferin	withaferin	VERB
bjp-19568	10	24	a	a	DET
bjp-19568	10	25	-	-	PUNCT
bjp-19568	10	26	induced	induced	ADJ
bjp-19568	10	27	inhibition	inhibition	NOUN
bjp-19568	10	28	of	of	ADP
bjp-19568	10	29	proliferation	proliferation	NOUN
bjp-19568	10	30	in	in	ADP
bjp-19568	10	31	osteosarcoma	osteosarcoma	ADJ
bjp-19568	10	32	cells	cell	NOUN
bjp-19568	10	33	.	.	PUNCT
bjp-19568	11	1	the	the	DET
bjp-19568	11	2	results	result	NOUN
bjp-19568	11	3	showed	show	VERB
bjp-19568	11	4	that	that	DET
bjp-19568	11	5	withaferin	withaferin	NOUN
bjp-19568	11	6	a	a	DET
bjp-19568	11	7	caused	cause	VERB
bjp-19568	11	8	marked	mark	VERB
bjp-19568	11	9	inhibition	inhibition	NOUN
bjp-19568	11	10	of	of	ADP
bjp-19568	11	11	osteosarcoma	osteosarcoma	ADJ
bjp-19568	11	12	cell	cell	NOUN
bjp-19568	11	13	growth	growth	NOUN
bjp-19568	11	14	and	and	CCONJ
bjp-19568	11	15	g2⁄m	g2⁄m	NUM
bjp-19568	11	16	phase	phase	NOUN
bjp-19568	11	17	cell	cell	NOUN
bjp-19568	11	18	cycle	cycle	NOUN
bjp-19568	11	19	arrest	arrest	NOUN
bjp-19568	11	20	.	.	PUNCT
bjp-19568	12	1	this	this	PRON
bjp-19568	12	2	was	be	AUX
bjp-19568	12	3	associated	associate	VERB
bjp-19568	12	4	with	with	ADP
bjp-19568	12	5	concomitant	concomitant	ADJ
bjp-19568	12	6	attenuation	attenuation	NOUN
bjp-19568	12	7	of	of	ADP
bjp-19568	12	8	notch-1	notch-1	NUM
bjp-19568	12	9	and	and	CCONJ
bjp-19568	12	10	down	down	ADP
bjp-19568	12	11	-	-	PUNCT
bjp-19568	12	12	regulation	regulation	NOUN
bjp-19568	12	13	of	of	ADP
bjp-19568	12	14	its	its	PRON
bjp-19568	12	15	downstream	downstream	ADJ
bjp-19568	12	16	genes	gene	NOUN
bjp-19568	12	17	,	,	PUNCT
bjp-19568	12	18	such	such	ADJ
bjp-19568	12	19	as	as	ADP
bjp-19568	12	20	matrix	matrix	NOUN
bjp-19568	12	21	metalloproteinases	metalloproteinase	NOUN
bjp-19568	12	22	.	.	PUNCT
bjp-19568	13	1	these	these	DET
bjp-19568	13	2	results	result	NOUN
bjp-19568	13	3	suggest	suggest	VERB
bjp-19568	13	4	that	that	SCONJ
bjp-19568	13	5	antitumor	antitumor	PROPN
bjp-19568	13	6	activity	activity	NOUN
bjp-19568	13	7	of	of	ADP
bjp-19568	13	8	withaferin	withaferin	NOUN
bjp-19568	13	9	a	a	PRON
bjp-19568	13	10	is	be	AUX
bjp-19568	13	11	mediated	mediate	VERB
bjp-19568	13	12	through	through	ADP
bjp-19568	13	13	a	a	DET
bjp-19568	13	14	novel	novel	ADJ
bjp-19568	13	15	mechanism	mechanism	NOUN
bjp-19568	13	16	involving	involve	VERB
bjp-19568	13	17	inactivation	inactivation	NOUN
bjp-19568	13	18	of	of	ADP
bjp-19568	13	19	the	the	DET
bjp-19568	13	20	notch-1	notch-1	NUM
bjp-19568	13	21	signaling	signal	VERB
bjp-19568	13	22	pathway	pathway	NOUN
bjp-19568	13	23	.	.	PUNCT
bjp-19568	14	1	our	our	PRON
bjp-19568	14	2	data	datum	NOUN
bjp-19568	14	3	provide	provide	VERB
bjp-19568	14	4	the	the	DET
bjp-19568	14	5	first	first	ADJ
bjp-19568	14	6	evidence	evidence	NOUN
bjp-19568	14	7	that	that	SCONJ
bjp-19568	14	8	the	the	DET
bjp-19568	14	9	down	down	ADJ
bjp-19568	14	10	regulation	regulation	NOUN
bjp-19568	14	11	of	of	ADP
bjp-19568	14	12	notch-1	notch-1	NUM
bjp-19568	14	13	by	by	ADP
bjp-19568	14	14	withaferin	withaferin	NOUN
bjp-19568	14	15	a	a	PRON
bjp-19568	14	16	may	may	AUX
bjp-19568	14	17	be	be	AUX
bjp-19568	14	18	an	an	DET
bjp-19568	14	19	effective	effective	ADJ
bjp-19568	14	20	approach	approach	NOUN
bjp-19568	14	21	for	for	ADP
bjp-19568	14	22	the	the	DET
bjp-19568	14	23	treatment	treatment	NOUN
bjp-19568	14	24	of	of	ADP
bjp-19568	14	25	osteosarcoma	osteosarcoma	NOUN
bjp-19568	14	26	.	.	PUNCT
bjp-19568	15	1	article	article	NOUN
bjp-19568	15	2	info	info	NOUN
bjp-19568	15	3	received	receive	VERB
bjp-19568	15	4	:	:	PUNCT
bjp-19568	15	5	18	18	NUM
bjp-19568	15	6	july	july	PROPN
bjp-19568	15	7	2014	2014	NUM
bjp-19568	15	8	accepted	accept	VERB
bjp-19568	15	9	:	:	PUNCT
bjp-19568	15	10	27	27	NUM
bjp-19568	15	11	july	july	PROPN
bjp-19568	15	12	2014	2014	NUM
bjp-19568	15	13	available	available	ADJ
bjp-19568	15	14	online	online	NOUN
bjp-19568	15	15	:	:	PUNCT
bjp-19568	15	16	19	19	NUM
bjp-19568	15	17	august	august	PROPN
bjp-19568	15	18	2014	2014	NUM
bjp-19568	15	19	doi	doi	NOUN
bjp-19568	15	20	:	:	PUNCT
bjp-19568	15	21	10.3329	10.3329	NUM
bjp-19568	15	22	/	/	SYM
bjp-19568	15	23	bjp.v9i3.19568	bjp.v9i3.19568	PROPN
bjp-19568	15	24	cite	cite	VERB
bjp-19568	15	25	this	this	DET
bjp-19568	15	26	article	article	NOUN
bjp-19568	15	27	:	:	PUNCT
bjp-19568	15	28	chen	chen	PROPN
bjp-19568	15	29	y	y	PROPN
bjp-19568	15	30	,	,	PUNCT
bjp-19568	15	31	han	han	PROPN
bjp-19568	15	32	xz	xz	PROPN
bjp-19568	15	33	,	,	PUNCT
bjp-19568	15	34	wang	wang	PROPN
bjp-19568	15	35	w	w	PROPN
bjp-19568	15	36	,	,	PUNCT
bjp-19568	15	37	zhao	zhao	PROPN
bjp-19568	15	38	rt	rt	PROPN
bjp-19568	15	39	,	,	PUNCT
bjp-19568	15	40	li	li	PROPN
bjp-19568	15	41	x.	x.	PROPN
bjp-19568	15	42	withaferin	withaferin	PROPN
bjp-19568	15	43	a	a	PRON
bjp-19568	15	44	inhibits	inhibit	VERB
bjp-19568	15	45	osteosarcoma	osteosarcoma	ADJ
bjp-19568	15	46	cells	cell	NOUN
bjp-19568	15	47	through	through	ADP
bjp-19568	15	48	inactivation	inactivation	NOUN
bjp-19568	15	49	of	of	ADP
bjp-19568	15	50	notch-1	notch-1	NUM
bjp-19568	15	51	signaling	signal	VERB
bjp-19568	15	52	.	.	PUNCT
bjp-19568	16	1	bangladesh	bangladesh	PROPN
bjp-19568	16	2	j	j	PROPN
bjp-19568	16	3	pharmacol	pharmacol	PROPN
bjp-19568	16	4	.	.	PUNCT
bjp-19568	16	5	2014	2014	NUM
bjp-19568	16	6	;	;	PUNCT
bjp-19568	16	7	9	9	NUM
bjp-19568	16	8	:	:	SYM
bjp-19568	16	9	364	364	NUM
bjp-19568	16	10	-	-	SYM
bjp-19568	16	11	70	70	NUM
bjp-19568	16	12	.	.	PUNCT
bjp-19568	17	1	this	this	DET
bjp-19568	17	2	work	work	NOUN
bjp-19568	17	3	is	be	AUX
bjp-19568	17	4	licensed	license	VERB
bjp-19568	17	5	under	under	ADP
bjp-19568	17	6	a	a	DET
bjp-19568	17	7	creative	creative	ADJ
bjp-19568	17	8	commons	common	NOUN
bjp-19568	17	9	attribution	attribution	NOUN
bjp-19568	17	10	3.0	3.0	NUM
bjp-19568	17	11	license	license	NOUN
bjp-19568	17	12	.	.	PUNCT
bjp-19568	18	1	you	you	PRON
bjp-19568	18	2	are	be	AUX
bjp-19568	18	3	free	free	ADJ
bjp-19568	18	4	to	to	PART
bjp-19568	18	5	copy	copy	VERB
bjp-19568	18	6	,	,	PUNCT
bjp-19568	18	7	distribute	distribute	VERB
bjp-19568	18	8	and	and	CCONJ
bjp-19568	18	9	perform	perform	VERB
bjp-19568	18	10	the	the	DET
bjp-19568	18	11	work	work	NOUN
bjp-19568	18	12	.	.	PUNCT
bjp-19568	19	1	you	you	PRON
bjp-19568	19	2	must	must	AUX
bjp-19568	19	3	attribute	attribute	VERB
bjp-19568	19	4	the	the	DET
bjp-19568	19	5	work	work	NOUN
bjp-19568	19	6	in	in	ADP
bjp-19568	19	7	the	the	DET
bjp-19568	19	8	manner	manner	NOUN
bjp-19568	19	9	specified	specify	VERB
bjp-19568	19	10	by	by	ADP
bjp-19568	19	11	the	the	DET
bjp-19568	19	12	author	author	NOUN
bjp-19568	19	13	or	or	CCONJ
bjp-19568	19	14	licensor	licensor	NOUN
bjp-19568	19	15	.	.	PUNCT
bjp-19568	20	1	withaferin	withaferin	PROPN
bjp-19568	20	2	a	a	PRON
bjp-19568	20	3	inhibits	inhibit	VERB
bjp-19568	20	4	osteosarcoma	osteosarcoma	ADJ
bjp-19568	20	5	cells	cell	NOUN
bjp-19568	20	6	through	through	ADP
bjp-19568	20	7	inactivation	inactivation	NOUN
bjp-19568	20	8	of	of	ADP
bjp-19568	20	9	notch-1	notch-1	NUM
bjp-19568	20	10	signaling	signal	VERB
bjp-19568	20	11	yang	yang	PROPN
bjp-19568	20	12	chen	chen	PROPN
bjp-19568	20	13	,	,	PUNCT
bjp-19568	20	14	xiang	xiang	PROPN
bjp-19568	20	15	zhen	zhen	PROPN
bjp-19568	20	16	han	han	PROPN
bjp-19568	20	17	,	,	PUNCT
bjp-19568	20	18	wei	wei	PROPN
bjp-19568	20	19	wang	wang	PROPN
bjp-19568	20	20	,	,	PUNCT
bjp-19568	20	21	ren	ren	PROPN
bjp-19568	20	22	tao	tao	PROPN
bjp-19568	20	23	zhao	zhao	PROPN
bjp-19568	20	24	and	and	CCONJ
bjp-19568	20	25	xiao	xiao	PROPN
bjp-19568	20	26	li	li	PROPN
bjp-19568	20	27	department	department	PROPN
bjp-19568	20	28	of	of	ADP
bjp-19568	20	29	bone	bone	NOUN
bjp-19568	20	30	tumor	tumor	NOUN
bjp-19568	20	31	,	,	PUNCT
bjp-19568	20	32	linyi	linyi	PROPN
bjp-19568	20	33	people	people	PROPN
bjp-19568	20	34	’s	’s	PART
bjp-19568	20	35	hospital	hospital	NOUN
bjp-19568	20	36	,	,	PUNCT
bjp-19568	20	37	shandong	shandong	PROPN
bjp-19568	20	38	276	276	NUM
bjp-19568	20	39	003	003	NUM
bjp-19568	20	40	,	,	PUNCT
bjp-19568	20	41	china	china	PROPN
bjp-19568	20	42	.	.	PUNCT
bjp-19568	21	1	cervix	cervix	NOUN
bjp-19568	21	2	(	(	PUNCT
bjp-19568	21	3	ramdass	ramdass	NOUN
bjp-19568	21	4	et	et	PROPN
bjp-19568	21	5	al	al	PROPN
bjp-19568	21	6	.	.	PROPN
bjp-19568	21	7	,	,	PUNCT
bjp-19568	21	8	2007	2007	NUM
bjp-19568	21	9	)	)	PUNCT
bjp-19568	21	10	and	and	CCONJ
bjp-19568	21	11	colon	colon	NOUN
bjp-19568	21	12	(	(	PUNCT
bjp-19568	21	13	katoh	katoh	NOUN
bjp-19568	21	14	,	,	PUNCT
bjp-19568	21	15	2007	2007	NUM
bjp-19568	21	16	)	)	PUNCT
bjp-19568	21	17	,	,	PUNCT
bjp-19568	21	18	as	as	ADV
bjp-19568	21	19	well	well	ADV
bjp-19568	21	20	as	as	ADP
bjp-19568	21	21	osteosarcoma	osteosarcoma	ADJ
bjp-19568	21	22	(	(	PUNCT
bjp-19568	21	23	engin	engin	PROPN
bjp-19568	21	24	et	et	PROPN
bjp-19568	21	25	al	al	PROPN
bjp-19568	21	26	.	.	PROPN
bjp-19568	21	27	,	,	PUNCT
bjp-19568	21	28	2009	2009	NUM
bjp-19568	21	29	)	)	PUNCT
bjp-19568	21	30	.	.	PUNCT
bjp-19568	22	1	it	it	PRON
bjp-19568	22	2	has	have	AUX
bjp-19568	22	3	also	also	ADV
bjp-19568	22	4	been	be	AUX
bjp-19568	22	5	reported	report	VERB
bjp-19568	22	6	that	that	SCONJ
bjp-19568	22	7	manipulation	manipulation	NOUN
bjp-19568	22	8	of	of	ADP
bjp-19568	22	9	notch-1	notch-1	NUM
bjp-19568	22	10	showed	show	VERB
bjp-19568	22	11	a	a	DET
bjp-19568	22	12	crucial	crucial	ADJ
bjp-19568	22	13	role	role	NOUN
bjp-19568	22	14	for	for	ADP
bjp-19568	22	15	hes-1	hes-1	X
bjp-19568	22	16	in	in	ADP
bjp-19568	22	17	osteosarcoma	osteosarcoma	ADJ
bjp-19568	22	18	invasion	invasion	NOUN
bjp-19568	22	19	and	and	CCONJ
bjp-19568	22	20	metastasis	metastasis	NOUN
bjp-19568	22	21	(	(	PUNCT
bjp-19568	22	22	zhang	zhang	X
bjp-19568	22	23	et	et	PROPN
bjp-19568	22	24	al	al	PROPN
bjp-19568	22	25	.	.	PROPN
bjp-19568	22	26	,	,	PUNCT
bjp-19568	22	27	2008	2008	NUM
bjp-19568	22	28	)	)	PUNCT
bjp-19568	22	29	.	.	PUNCT
bjp-19568	23	1	moreover	moreover	ADV
bjp-19568	23	2	,	,	PUNCT
bjp-19568	23	3	inhibition	inhibition	NOUN
bjp-19568	23	4	of	of	ADP
bjp-19568	23	5	the	the	DET
bjp-19568	23	6	notch	notch	ADJ
bjp-19568	23	7	pathway	pathway	NOUN
bjp-19568	23	8	using	use	VERB
bjp-19568	23	9	c	c	NOUN
bjp-19568	23	10	-	-	PUNCT
bjp-19568	23	11	secretase	secretase	NOUN
bjp-19568	23	12	inhibitor	inhibitor	NOUN
bjp-19568	23	13	and	and	CCONJ
bjp-19568	23	14	cbf1	cbf1	PROPN
bjp-19568	23	15	small	small	ADV
bjp-19568	23	16	-	-	PUNCT
bjp-19568	23	17	interfering	interfere	VERB
bjp-19568	23	18	rna	rna	NOUN
bjp-19568	23	19	(	(	PUNCT
bjp-19568	23	20	sirna	sirna	PROPN
bjp-19568	23	21	)	)	PUNCT
bjp-19568	23	22	suppressed	suppress	VERB
bjp-19568	23	23	osteosarcoma	osteosarcoma	ADJ
bjp-19568	23	24	growth	growth	NOUN
bjp-19568	23	25	in	in	ADP
bjp-19568	23	26	vitro	vitro	X
bjp-19568	23	27	and	and	CCONJ
bjp-19568	23	28	in	in	ADP
bjp-19568	23	29	vivo	vivo	NOUN
bjp-19568	23	30	(	(	PUNCT
bjp-19568	23	31	tanaka	tanaka	PROPN
bjp-19568	23	32	et	et	NOUN
bjp-19568	23	33	al	al	PROPN
bjp-19568	23	34	2009	2009	NUM
bjp-19568	23	35	)	)	PUNCT
bjp-19568	23	36	.	.	PUNCT
bjp-19568	24	1	therefore	therefore	ADV
bjp-19568	24	2	,	,	PUNCT
bjp-19568	24	3	the	the	DET
bjp-19568	24	4	down	down	NOUN
bjp-19568	24	5	-	-	PUNCT
bjp-19568	24	6	regulation	regulation	NOUN
bjp-19568	24	7	of	of	ADP
bjp-19568	24	8	notch	notch	NOUN
bjp-19568	24	9	signaling	signal	VERB
bjp-19568	24	10	may	may	AUX
bjp-19568	24	11	be	be	AUX
bjp-19568	24	12	an	an	DET
bjp-19568	24	13	effective	effective	ADJ
bjp-19568	24	14	approach	approach	NOUN
bjp-19568	24	15	for	for	ADP
bjp-19568	24	16	osteosarcoma	osteosarcoma	ADJ
bjp-19568	24	17	therapy	therapy	NOUN
bjp-19568	24	18	.	.	PUNCT
bjp-19568	25	1	in	in	ADP
bjp-19568	25	2	this	this	DET
bjp-19568	25	3	study	study	NOUN
bjp-19568	25	4	,	,	PUNCT
bjp-19568	25	5	antiproliferative	antiproliferative	ADJ
bjp-19568	25	6	effects	effect	NOUN
bjp-19568	25	7	of	of	ADP
bjp-19568	25	8	wa	wa	ADJ
bjp-19568	25	9	have	have	AUX
bjp-19568	25	10	been	be	AUX
bjp-19568	25	11	studied	study	VERB
bjp-19568	25	12	in	in	ADP
bjp-19568	25	13	two	two	NUM
bjp-19568	25	14	osteosarcoma	osteosarcoma	ADJ
bjp-19568	25	15	cell	cell	NOUN
bjp-19568	25	16	lines	line	NOUN
bjp-19568	25	17	namely	namely	ADV
bjp-19568	25	18	(	(	PUNCT
bjp-19568	25	19	u2os	u2os	PUNCT
bjp-19568	25	20	and	and	CCONJ
bjp-19568	25	21	mg-63	mg-63	NOUN
bjp-19568	25	22	)	)	PUNCT
bjp-19568	25	23	.	.	PUNCT
bjp-19568	26	1	the	the	DET
bjp-19568	26	2	mechanism	mechanism	NOUN
bjp-19568	26	3	of	of	ADP
bjp-19568	26	4	action	action	NOUN
bjp-19568	26	5	of	of	ADP
bjp-19568	26	6	cell	cell	NOUN
bjp-19568	26	7	cycle	cycle	NOUN
bjp-19568	26	8	arrest	arrest	NOUN
bjp-19568	26	9	and	and	CCONJ
bjp-19568	26	10	apoptosis	apoptosis	NOUN
bjp-19568	26	11	were	be	AUX
bjp-19568	26	12	also	also	ADV
bjp-19568	26	13	investigated	investigate	VERB
bjp-19568	26	14	.	.	PUNCT
bjp-19568	27	1	materials	material	NOUN
bjp-19568	27	2	and	and	CCONJ
bjp-19568	27	3	methods	method	NOUN
bjp-19568	27	4	reagents	reagent	NOUN
bjp-19568	27	5	bovine	bovine	VERB
bjp-19568	27	6	serum	serum	NOUN
bjp-19568	27	7	albumin	albumin	PROPN
bjp-19568	27	8	(	(	PUNCT
bjp-19568	27	9	bsa	bsa	PROPN
bjp-19568	27	10	)	)	PUNCT
bjp-19568	27	11	,	,	PUNCT
bjp-19568	27	12	ribonuclease	ribonuclease	NOUN
bjp-19568	27	13	a	a	NOUN
bjp-19568	27	14	(	(	PUNCT
bjp-19568	27	15	rnase	rnase	PROPN
bjp-19568	27	16	a	a	PROPN
bjp-19568	27	17	)	)	PUNCT
bjp-19568	27	18	,	,	PUNCT
bjp-19568	27	19	propidium	propidium	NOUN
bjp-19568	27	20	iodide	iodide	NOUN
bjp-19568	27	21	(	(	PUNCT
bjp-19568	27	22	pi	pi	NOUN
bjp-19568	27	23	)	)	PUNCT
bjp-19568	27	24	,	,	PUNCT
bjp-19568	27	25	trichloroacetic	trichloroacetic	ADJ
bjp-19568	27	26	acid	acid	NOUN
bjp-19568	27	27	(	(	PUNCT
bjp-19568	27	28	tca	tca	PROPN
bjp-19568	27	29	)	)	PUNCT
bjp-19568	27	30	,	,	PUNCT
bjp-19568	27	31	sulforhodamine	sulforhodamine	NOUN
bjp-19568	27	32	b	b	PROPN
bjp-19568	27	33	(	(	PUNCT
bjp-19568	27	34	srb	srb	PROPN
bjp-19568	27	35	)	)	PUNCT
bjp-19568	27	36	,	,	PUNCT
bjp-19568	27	37	anti	anti	ADJ
bjp-19568	27	38	-	-	ADJ
bjp-19568	27	39	β	β	ADJ
bjp-19568	27	40	-	-	PUNCT
bjp-19568	27	41	actin	actin	ADJ
bjp-19568	27	42	antibody	antibody	NOUN
bjp-19568	27	43	and	and	CCONJ
bjp-19568	27	44	withaferin	withaferin	NOUN
bjp-19568	27	45	a	a	PRON
bjp-19568	27	46	were	be	AUX
bjp-19568	27	47	purchased	purchase	VERB
bjp-19568	27	48	from	from	ADP
bjp-19568	27	49	sigma	sigma	PROPN
bjp-19568	27	50	(	(	PUNCT
bjp-19568	27	51	st.louis	st.louis	PROPN
bjp-19568	27	52	,	,	PUNCT
bjp-19568	27	53	mo	mo	PROPN
bjp-19568	27	54	,	,	PUNCT
bjp-19568	27	55	usa	usa	PROPN
bjp-19568	27	56	)	)	PUNCT
bjp-19568	27	57	.	.	PUNCT
bjp-19568	28	1	fetal	fetal	ADJ
bjp-19568	28	2	bovine	bovine	NOUN
bjp-19568	28	3	serum	serum	NOUN
bjp-19568	28	4	(	(	PUNCT
bjp-19568	28	5	fbs	fbs	PROPN
bjp-19568	28	6	)	)	PUNCT
bjp-19568	28	7	,	,	PUNCT
bjp-19568	28	8	rpmi	rpmi	NOUN
bjp-19568	28	9	1640	1640	NUM
bjp-19568	28	10	,	,	PUNCT
bjp-19568	28	11	trypsin	trypsin	NOUN
bjp-19568	28	12	-	-	PUNCT
bjp-19568	28	13	edta	edta	NOUN
bjp-19568	28	14	and	and	CCONJ
bjp-19568	28	15	antibiotic	antibiotic	ADJ
bjp-19568	28	16	-	-	PUNCT
bjp-19568	28	17	antimycotic	antimycotic	ADJ
bjp-19568	28	18	solution	solution	NOUN
bjp-19568	28	19	were	be	AUX
bjp-19568	28	20	purchased	purchase	VERB
bjp-19568	28	21	from	from	ADP
bjp-19568	28	22	gibco	gibco	NOUN
bjp-19568	28	23	-	-	PUNCT
bjp-19568	28	24	brl	brl	NOUN
bjp-19568	28	25	(	(	PUNCT
bjp-19568	28	26	grand	grand	ADJ
bjp-19568	28	27	island	island	NOUN
bjp-19568	28	28	,	,	PUNCT
bjp-19568	28	29	ny	ny	PROPN
bjp-19568	28	30	,	,	PUNCT
bjp-19568	28	31	usa	usa	PROPN
bjp-19568	28	32	)	)	PUNCT
bjp-19568	28	33	.	.	PUNCT
bjp-19568	29	1	primary	primary	ADJ
bjp-19568	29	2	antibodies	antibody	NOUN
bjp-19568	29	3	for	for	ADP
bjp-19568	29	4	notch-1	notch-1	NUM
bjp-19568	29	5	intracellular	intracellular	ADJ
bjp-19568	29	6	domain	domain	NOUN
bjp-19568	29	7	and	and	CCONJ
bjp-19568	29	8	hes-1	hes-1	NUM
bjp-19568	29	9	were	be	AUX
bjp-19568	29	10	purchased	purchase	VERB
bjp-19568	29	11	from	from	ADP
bjp-19568	29	12	abcam	abcam	PROPN
bjp-19568	29	13	(	(	PUNCT
bjp-19568	29	14	cambridge	cambridge	PROPN
bjp-19568	29	15	,	,	PUNCT
bjp-19568	29	16	uk	uk	PROPN
bjp-19568	29	17	)	)	PUNCT
bjp-19568	29	18	.	.	PUNCT
bjp-19568	30	1	primary	primary	ADJ
bjp-19568	30	2	antibodies	antibody	NOUN
bjp-19568	30	3	for	for	ADP
bjp-19568	30	4	cyclin	cyclin	NOUN
bjp-19568	30	5	d1	d1	PROPN
bjp-19568	30	6	,	,	PUNCT
bjp-19568	30	7	mmp-2	mmp-2	NUM
bjp-19568	30	8	and	and	CCONJ
bjp-19568	30	9	mmp-9	mmp-9	NOUN
bjp-19568	30	10	were	be	AUX
bjp-19568	30	11	obtained	obtain	VERB
bjp-19568	30	12	from	from	ADP
bjp-19568	30	13	cell	cell	NOUN
bjp-19568	30	14	signaling	signal	VERB
bjp-19568	30	15	technology	technology	NOUN
bjp-19568	30	16	(	(	PUNCT
bjp-19568	30	17	beverly	beverly	PROPN
bjp-19568	30	18	,	,	PUNCT
bjp-19568	30	19	ma	ma	PROPN
bjp-19568	30	20	,	,	PUNCT
bjp-19568	30	21	usa	usa	PROPN
bjp-19568	30	22	)	)	PUNCT
bjp-19568	30	23	.	.	PUNCT
bjp-19568	31	1	cell	cell	NOUN
bjp-19568	31	2	lines	line	NOUN
bjp-19568	31	3	and	and	CCONJ
bjp-19568	31	4	culture	culture	NOUN
bjp-19568	31	5	human	human	ADJ
bjp-19568	31	6	osteosarcoma	osteosarcoma	ADJ
bjp-19568	31	7	cell	cell	NOUN
bjp-19568	31	8	lines	line	NOUN
bjp-19568	31	9	mg-63	mg-63	NOUN
bjp-19568	31	10	,	,	PUNCT
bjp-19568	31	11	u2os	u2os	PUNCT
bjp-19568	31	12	and	and	CCONJ
bjp-19568	31	13	mg63	mg63	PROPN
bjp-19568	31	14	were	be	AUX
bjp-19568	31	15	obtained	obtain	VERB
bjp-19568	31	16	from	from	ADP
bjp-19568	31	17	the	the	DET
bjp-19568	31	18	china	china	PROPN
bjp-19568	31	19	center	center	PROPN
bjp-19568	31	20	for	for	ADP
bjp-19568	31	21	type	type	NOUN
bjp-19568	31	22	culture	culture	NOUN
bjp-19568	31	23	collection	collection	NOUN
bjp-19568	31	24	(	(	PUNCT
bjp-19568	31	25	cctcc	cctcc	NOUN
bjp-19568	31	26	)	)	PUNCT
bjp-19568	31	27	.	.	PUNCT
bjp-19568	32	1	the	the	DET
bjp-19568	32	2	cells	cell	NOUN
bjp-19568	32	3	were	be	AUX
bjp-19568	32	4	cultured	cultured	ADJ
bjp-19568	32	5	with	with	ADP
bjp-19568	32	6	high	high	ADJ
bjp-19568	32	7	glucose	glucose	NOUN
bjp-19568	32	8	dmem	dmem	NOUN
bjp-19568	32	9	supplemented	supplement	VERB
bjp-19568	32	10	with	with	ADP
bjp-19568	32	11	10	10	NUM
bjp-19568	32	12	%	%	NOUN
bjp-19568	32	13	fbs	fbs	PROPN
bjp-19568	32	14	,	,	PUNCT
bjp-19568	32	15	100	100	NUM
bjp-19568	32	16	u	u	NOUN
bjp-19568	32	17	/	/	SYM
bjp-19568	32	18	ml	ml	NOUN
bjp-19568	32	19	of	of	ADP
bjp-19568	32	20	penicillin	penicillin	NOUN
bjp-19568	32	21	g	g	PROPN
bjp-19568	32	22	and	and	CCONJ
bjp-19568	32	23	100	100	NUM
bjp-19568	32	24	u	u	NOUN
bjp-19568	32	25	/	/	SYM
bjp-19568	32	26	ml	ml	PROPN
bjp-19568	32	27	of	of	ADP
bjp-19568	32	28	streptomycin	streptomycin	PROPN
bjp-19568	32	29	.	.	PUNCT
bjp-19568	33	1	they	they	PRON
bjp-19568	33	2	were	be	AUX
bjp-19568	33	3	cultured	cultured	ADJ
bjp-19568	33	4	at	at	ADP
bjp-19568	33	5	37	37	NUM
bjp-19568	33	6	°	°	ADP
bjp-19568	33	7	c	c	NOUN
bjp-19568	33	8	in	in	ADP
bjp-19568	33	9	a	a	DET
bjp-19568	33	10	humidified	humidified	ADJ
bjp-19568	33	11	incubator	incubator	NOUN
bjp-19568	33	12	with	with	ADP
bjp-19568	33	13	5	5	NUM
bjp-19568	33	14	%	%	NOUN
bjp-19568	33	15	co2	co2	NOUN
bjp-19568	33	16	.	.	PUNCT
bjp-19568	34	1	all	all	DET
bjp-19568	34	2	cells	cell	NOUN
bjp-19568	34	3	used	use	VERB
bjp-19568	34	4	in	in	ADP
bjp-19568	34	5	the	the	DET
bjp-19568	34	6	studies	study	NOUN
bjp-19568	34	7	were	be	AUX
bjp-19568	34	8	in	in	ADP
bjp-19568	34	9	the	the	DET
bjp-19568	34	10	logarithmic	logarithmic	ADJ
bjp-19568	34	11	phase	phase	NOUN
bjp-19568	34	12	.	.	PUNCT
bjp-19568	35	1	cell	cell	NOUN
bjp-19568	35	2	cytotoxicity	cytotoxicity	NOUN
bjp-19568	35	3	assay	assay	VERB
bjp-19568	35	4	u2os	u2os	PUNCT
bjp-19568	35	5	,	,	PUNCT
bjp-19568	35	6	saos-2	saos-2	NUM
bjp-19568	35	7	and	and	CCONJ
bjp-19568	35	8	mg-63	mg-63	NOUN
bjp-19568	35	9	cells	cell	NOUN
bjp-19568	35	10	(	(	PUNCT
bjp-19568	35	11	8	8	NUM
bjp-19568	35	12	×	×	NOUN
bjp-19568	35	13	103	103	NUM
bjp-19568	35	14	,	,	PUNCT
bjp-19568	35	15	5	5	NUM
bjp-19568	35	16	×	×	NOUN
bjp-19568	35	17	103	103	NUM
bjp-19568	35	18	and	and	CCONJ
bjp-19568	35	19	6	6	NUM
bjp-19568	35	20	×	×	NOUN
bjp-19568	35	21	103	103	NUM
bjp-19568	35	22	,	,	PUNCT
bjp-19568	35	23	respectively	respectively	ADV
bjp-19568	35	24	)	)	PUNCT
bjp-19568	35	25	were	be	AUX
bjp-19568	35	26	seeded	seed	VERB
bjp-19568	35	27	in	in	ADP
bjp-19568	35	28	a	a	DET
bjp-19568	35	29	96	96	NUM
bjp-19568	35	30	-	-	PUNCT
bjp-19568	35	31	well	well	NOUN
bjp-19568	35	32	culture	culture	NOUN
bjp-19568	35	33	plate	plate	NOUN
bjp-19568	35	34	.	.	PUNCT
bjp-19568	36	1	after	after	ADP
bjp-19568	36	2	12	12	NUM
bjp-19568	36	3	hours	hour	NOUN
bjp-19568	36	4	,	,	PUNCT
bjp-19568	36	5	cells	cell	NOUN
bjp-19568	36	6	were	be	AUX
bjp-19568	36	7	treated	treat	VERB
bjp-19568	36	8	with	with	ADP
bjp-19568	36	9	10	10	NUM
bjp-19568	36	10	,	,	PUNCT
bjp-19568	36	11	20	20	NUM
bjp-19568	36	12	,	,	PUNCT
bjp-19568	36	13	30	30	NUM
bjp-19568	36	14	and	and	CCONJ
bjp-19568	36	15	40	40	NUM
bjp-19568	36	16	µm	µm	NOUN
bjp-19568	36	17	of	of	ADP
bjp-19568	36	18	withaferin	withaferin	NOUN
bjp-19568	36	19	a	a	PRON
bjp-19568	36	20	for	for	ADP
bjp-19568	36	21	24	24	NUM
bjp-19568	36	22	,	,	PUNCT
bjp-19568	36	23	48	48	NUM
bjp-19568	36	24	and	and	CCONJ
bjp-19568	36	25	72	72	NUM
bjp-19568	36	26	hours	hour	NOUN
bjp-19568	36	27	.	.	PUNCT
bjp-19568	37	1	control	control	NOUN
bjp-19568	37	2	cells	cell	NOUN
bjp-19568	37	3	were	be	AUX
bjp-19568	37	4	treated	treat	VERB
bjp-19568	37	5	with	with	ADP
bjp-19568	37	6	0.1	0.1	NUM
bjp-19568	37	7	%	%	NOUN
bjp-19568	37	8	dimethyl	dimethyl	NOUN
bjp-19568	37	9	-	-	PUNCT
bjp-19568	37	10	sulfoxide	sulfoxide	NOUN
bjp-19568	37	11	in	in	ADP
bjp-19568	37	12	culture	culture	NOUN
bjp-19568	37	13	medium	medium	NOUN
bjp-19568	37	14	.	.	PUNCT
bjp-19568	38	1	after	after	ADP
bjp-19568	38	2	treatment	treatment	NOUN
bjp-19568	38	3	,	,	PUNCT
bjp-19568	38	4	the	the	DET
bjp-19568	38	5	cells	cell	NOUN
bjp-19568	38	6	were	be	AUX
bjp-19568	38	7	incubated	incubate	VERB
bjp-19568	38	8	with	with	ADP
bjp-19568	38	9	mtt	mtt	NOUN
bjp-19568	38	10	solution	solution	NOUN
bjp-19568	38	11	(	(	PUNCT
bjp-19568	38	12	5	5	NUM
bjp-19568	38	13	mg	mg	NUM
bjp-19568	38	14	/	/	SYM
bjp-19568	38	15	ml	ml	NOUN
bjp-19568	38	16	in	in	ADP
bjp-19568	38	17	phosphate	phosphate	NOUN
bjp-19568	38	18	-	-	PUNCT
bjp-19568	38	19	buffered	buffer	VERB
bjp-19568	38	20	saline	saline	NOUN
bjp-19568	38	21	,	,	PUNCT
bjp-19568	38	22	nacl	nacl	NOUN
bjp-19568	38	23	/	/	SYM
bjp-19568	38	24	pi	pi	NOUN
bjp-19568	38	25	)	)	PUNCT
bjp-19568	38	26	at	at	ADP
bjp-19568	38	27	37	37	NUM
bjp-19568	38	28	°	°	ADP
bjp-19568	38	29	c	c	NOUN
bjp-19568	38	30	for	for	ADP
bjp-19568	38	31	4	4	NUM
bjp-19568	38	32	hours	hour	NOUN
bjp-19568	38	33	and	and	CCONJ
bjp-19568	38	34	then	then	ADV
bjp-19568	38	35	with	with	ADP
bjp-19568	38	36	dimethylsulfoxide	dimethylsulfoxide	ADV
bjp-19568	38	37	by	by	ADP
bjp-19568	38	38	shaking	shake	VERB
bjp-19568	38	39	at	at	ADP
bjp-19568	38	40	room	room	NOUN
bjp-19568	38	41	temperature	temperature	NOUN
bjp-19568	38	42	for	for	ADP
bjp-19568	38	43	10	10	NUM
bjp-19568	38	44	min	min	NOUN
bjp-19568	38	45	.	.	PUNCT
bjp-19568	39	1	the	the	DET
bjp-19568	39	2	spectrophotometric	spectrophotometric	ADJ
bjp-19568	39	3	absorbance	absorbance	NOUN
bjp-19568	39	4	was	be	AUX
bjp-19568	39	5	measured	measure	VERB
bjp-19568	39	6	at	at	ADP
bjp-19568	39	7	570	570	NUM
bjp-19568	39	8	nm	nm	NOUN
bjp-19568	39	9	on	on	ADP
bjp-19568	39	10	a	a	DET
bjp-19568	39	11	multifunctional	multifunctional	ADJ
bjp-19568	39	12	microplate	microplate	NOUN
bjp-19568	39	13	reader	reader	NOUN
bjp-19568	39	14	(	(	PUNCT
bjp-19568	39	15	tecan	tecan	PROPN
bjp-19568	39	16	,	,	PUNCT
bjp-19568	39	17	usa	usa	PROPN
bjp-19568	39	18	)	)	PUNCT
bjp-19568	39	19	.	.	PUNCT
bjp-19568	40	1	cell	cell	NOUN
bjp-19568	40	2	viability	viability	NOUN
bjp-19568	40	3	was	be	AUX
bjp-19568	40	4	expressed	express	VERB
bjp-19568	40	5	as	as	ADP
bjp-19568	40	6	the	the	DET
bjp-19568	40	7	relative	relative	ADJ
bjp-19568	40	8	formazan	formazan	ADJ
bjp-19568	40	9	formation	formation	NOUN
bjp-19568	40	10	in	in	ADP
bjp-19568	40	11	treated	treat	VERB
bjp-19568	40	12	samples	sample	NOUN
bjp-19568	40	13	compared	compare	VERB
bjp-19568	40	14	with	with	ADP
bjp-19568	40	15	control	control	NOUN
bjp-19568	40	16	cells	cell	NOUN
bjp-19568	40	17	after	after	ADP
bjp-19568	40	18	correction	correction	NOUN
bjp-19568	40	19	for	for	ADP
bjp-19568	40	20	background	background	NOUN
bjp-19568	40	21	absorbance	absorbance	NOUN
bjp-19568	40	22	.	.	PUNCT
bjp-19568	41	1	the	the	DET
bjp-19568	41	2	ic50	ic50	PROPN
bjp-19568	41	3	values	value	NOUN
bjp-19568	41	4	,	,	PUNCT
bjp-19568	41	5	defined	define	VERB
bjp-19568	41	6	as	as	ADP
bjp-19568	41	7	the	the	DET
bjp-19568	41	8	concentration	concentration	NOUN
bjp-19568	41	9	inducing	induce	VERB
bjp-19568	41	10	50	50	NUM
bjp-19568	41	11	%	%	NOUN
bjp-19568	41	12	loss	loss	NOUN
bjp-19568	41	13	of	of	ADP
bjp-19568	41	14	cell	cell	NOUN
bjp-19568	41	15	viability	viability	NOUN
bjp-19568	41	16	,	,	PUNCT
bjp-19568	41	17	were	be	AUX
bjp-19568	41	18	estimated	estimate	VERB
bjp-19568	41	19	from	from	ADP
bjp-19568	41	20	the	the	DET
bjp-19568	41	21	dose	dose	NOUN
bjp-19568	41	22	-	-	PUNCT
bjp-19568	41	23	response	response	NOUN
bjp-19568	41	24	curves	curve	NOUN
bjp-19568	41	25	.	.	PUNCT
bjp-19568	42	1	results	result	NOUN
bjp-19568	42	2	were	be	AUX
bjp-19568	42	3	plotted	plot	VERB
bjp-19568	42	4	as	as	ADP
bjp-19568	42	5	the	the	DET
bjp-19568	42	6	mean	mean	ADJ
bjp-19568	42	7	±	±	PROPN
bjp-19568	42	8	sd	sd	NOUN
bjp-19568	42	9	of	of	ADP
bjp-19568	42	10	three	three	NUM
bjp-19568	42	11	separate	separate	ADJ
bjp-19568	42	12	experiments	experiment	NOUN
bjp-19568	42	13	from	from	ADP
bjp-19568	42	14	six	six	NUM
bjp-19568	42	15	determinations	determination	NOUN
bjp-19568	42	16	per	per	ADP
bjp-19568	42	17	experiment	experiment	NOUN
bjp-19568	42	18	for	for	ADP
bjp-19568	42	19	each	each	DET
bjp-19568	42	20	experimental	experimental	ADJ
bjp-19568	42	21	condition	condition	NOUN
bjp-19568	42	22	.	.	PUNCT
bjp-19568	43	1	cell	cell	NOUN
bjp-19568	43	2	cycle	cycle	NOUN
bjp-19568	43	3	analysis	analysis	NOUN
bjp-19568	43	4	u2os	u2os	PUNCT
bjp-19568	43	5	,	,	PUNCT
bjp-19568	43	6	saos-2	saos-2	NUM
bjp-19568	43	7	and	and	CCONJ
bjp-19568	43	8	mg-63	mg-63	NOUN
bjp-19568	43	9	cells	cell	NOUN
bjp-19568	43	10	were	be	AUX
bjp-19568	43	11	plated	plate	VERB
bjp-19568	43	12	at	at	ADP
bjp-19568	43	13	a	a	DET
bjp-19568	43	14	density	density	NOUN
bjp-19568	43	15	of	of	ADP
bjp-19568	43	16	1	1	NUM
bjp-19568	43	17	×	×	NOUN
bjp-19568	43	18	106	106	NUM
bjp-19568	43	19	cells	cell	NOUN
bjp-19568	43	20	per	per	ADP
bjp-19568	43	21	100	100	NUM
bjp-19568	43	22	mm	mm	NOUN
bjp-19568	43	23	culture	culture	NOUN
bjp-19568	43	24	dish	dish	NOUN
bjp-19568	43	25	and	and	CCONJ
bjp-19568	43	26	incubated	incubate	VERB
bjp-19568	43	27	for	for	ADP
bjp-19568	43	28	24	24	NUM
bjp-19568	43	29	hours	hour	NOUN
bjp-19568	43	30	.	.	PUNCT
bjp-19568	44	1	we	we	PRON
bjp-19568	44	2	replaced	replace	VERB
bjp-19568	44	3	the	the	DET
bjp-19568	44	4	medium	medium	NOUN
bjp-19568	44	5	with	with	ADP
bjp-19568	44	6	fresh	fresh	ADJ
bjp-19568	44	7	medium	medium	NOUN
bjp-19568	44	8	containing	contain	VERB
bjp-19568	44	9	various	various	ADJ
bjp-19568	44	10	concentrations	concentration	NOUN
bjp-19568	44	11	of	of	ADP
bjp-19568	44	12	wa	wa	ADJ
bjp-19568	44	13	(	(	PUNCT
bjp-19568	44	14	1	1	NUM
bjp-19568	44	15	,	,	PUNCT
bjp-19568	44	16	10	10	NUM
bjp-19568	44	17	and	and	CCONJ
bjp-19568	44	18	100	100	NUM
bjp-19568	44	19	μm	μm	NUM
bjp-19568	44	20	)	)	PUNCT
bjp-19568	44	21	and	and	CCONJ
bjp-19568	44	22	0.1	0.1	NUM
bjp-19568	44	23	%	%	NOUN
bjp-19568	44	24	dmso	dmso	NOUN
bjp-19568	44	25	alone	alone	ADV
bjp-19568	44	26	.	.	PUNCT
bjp-19568	45	1	following	follow	VERB
bjp-19568	45	2	24	24	NUM
bjp-19568	45	3	hours	hour	NOUN
bjp-19568	45	4	of	of	ADP
bjp-19568	45	5	treatment	treatment	NOUN
bjp-19568	45	6	at	at	ADP
bjp-19568	45	7	37	37	NUM
bjp-19568	45	8	°	°	NOUN
bjp-19568	45	9	c	c	NOUN
bjp-19568	45	10	,	,	PUNCT
bjp-19568	45	11	all	all	DET
bjp-19568	45	12	cells	cell	NOUN
bjp-19568	45	13	were	be	AUX
bjp-19568	45	14	collected	collect	VERB
bjp-19568	45	15	,	,	PUNCT
bjp-19568	45	16	washed	wash	VERB
bjp-19568	45	17	with	with	ADP
bjp-19568	45	18	phosphate	phosphate	NOUN
bjp-19568	45	19	-	-	PUNCT
bjp-19568	45	20	buffered	buffer	VERB
bjp-19568	45	21	saline	saline	NOUN
bjp-19568	45	22	(	(	PUNCT
bjp-19568	45	23	pbs	pbs	PROPN
bjp-19568	45	24	)	)	PUNCT
bjp-19568	45	25	,	,	PUNCT
bjp-19568	45	26	and	and	CCONJ
bjp-19568	45	27	fixed	fix	VERB
bjp-19568	45	28	with	with	ADP
bjp-19568	45	29	70	70	NUM
bjp-19568	45	30	%	%	NOUN
bjp-19568	45	31	(	(	PUNCT
bjp-19568	45	32	v	v	NOUN
bjp-19568	45	33	/	/	SYM
bjp-19568	45	34	v	v	NOUN
bjp-19568	45	35	)	)	PUNCT
bjp-19568	45	36	ice	ice	NOUN
bjp-19568	45	37	-	-	PUNCT
bjp-19568	45	38	cold	cold	ADJ
bjp-19568	45	39	ethanol	ethanol	NOUN
bjp-19568	45	40	for	for	ADP
bjp-19568	45	41	1	1	NUM
bjp-19568	45	42	hour	hour	NOUN
bjp-19568	45	43	at	at	ADP
bjp-19568	45	44	4	4	NUM
bjp-19568	45	45	°	°	NOUN
bjp-19568	45	46	c	c	NOUN
bjp-19568	45	47	.	.	PUNCT
bjp-19568	46	1	the	the	DET
bjp-19568	46	2	fixed	fix	VERB
bjp-19568	46	3	cells	cell	NOUN
bjp-19568	46	4	were	be	AUX
bjp-19568	46	5	treated	treat	VERB
bjp-19568	46	6	with	with	ADP
bjp-19568	46	7	50	50	NUM
bjp-19568	46	8	μg	μg	NOUN
bjp-19568	46	9	/	/	SYM
bjp-19568	46	10	ml	ml	NOUN
bjp-19568	46	11	rnase	rnase	PROPN
bjp-19568	46	12	a	a	PRON
bjp-19568	46	13	and	and	CCONJ
bjp-19568	46	14	50	50	NUM
bjp-19568	46	15	μg/	μg/	NOUN
bjp-19568	46	16	ml	ml	NOUN
bjp-19568	46	17	pi	pi	NOUN
bjp-19568	46	18	for	for	ADP
bjp-19568	46	19	30	30	NUM
bjp-19568	46	20	min	min	NOUN
bjp-19568	46	21	at	at	ADP
bjp-19568	46	22	room	room	NOUN
bjp-19568	46	23	temperature	temperature	NOUN
bjp-19568	46	24	.	.	PUNCT
bjp-19568	47	1	at	at	ADV
bjp-19568	47	2	least	least	ADJ
bjp-19568	47	3	10,000	10,000	NUM
bjp-19568	47	4	cells	cell	NOUN
bjp-19568	47	5	were	be	AUX
bjp-19568	47	6	analyzed	analyze	VERB
bjp-19568	47	7	by	by	ADP
bjp-19568	47	8	flow	flow	NOUN
bjp-19568	47	9	cytometry	cytometry	NOUN
bjp-19568	47	10	(	(	PUNCT
bjp-19568	47	11	facscalibur	facscalibur	PROPN
bjp-19568	47	12	,	,	PUNCT
bjp-19568	47	13	becton	becton	PROPN
bjp-19568	47	14	dickinson	dickinson	PROPN
bjp-19568	47	15	,	,	PUNCT
bjp-19568	47	16	usa	usa	PROPN
bjp-19568	47	17	)	)	PUNCT
bjp-19568	47	18	.	.	PUNCT
bjp-19568	48	1	data	datum	NOUN
bjp-19568	48	2	analysis	analysis	NOUN
bjp-19568	48	3	was	be	AUX
bjp-19568	48	4	performed	perform	VERB
bjp-19568	48	5	using	use	VERB
bjp-19568	48	6	cell	cell	NOUN
bjp-19568	48	7	quest	quest	NOUN
bjp-19568	48	8	cell	cell	NOUN
bjp-19568	48	9	cycle	cycle	NOUN
bjp-19568	48	10	analysis	analysis	NOUN
bjp-19568	48	11	software	software	NOUN
bjp-19568	48	12	.	.	PUNCT
bjp-19568	49	1	western	western	ADJ
bjp-19568	49	2	blot	blot	NOUN
bjp-19568	49	3	analysis	analysis	NOUN
bjp-19568	49	4	u2os	u2os	X
bjp-19568	49	5	and	and	CCONJ
bjp-19568	49	6	mg-63	mg-63	NOUN
bjp-19568	49	7	human	human	ADJ
bjp-19568	49	8	osteocarcinoma	osteocarcinoma	NOUN
bjp-19568	49	9	cells	cell	NOUN
bjp-19568	49	10	were	be	AUX
bjp-19568	49	11	exposed	expose	VERB
bjp-19568	49	12	to	to	ADP
bjp-19568	49	13	various	various	ADJ
bjp-19568	49	14	concentrations	concentration	NOUN
bjp-19568	49	15	of	of	ADP
bjp-19568	49	16	wa	wa	NOUN
bjp-19568	49	17	for	for	ADP
bjp-19568	49	18	24	24	NUM
bjp-19568	49	19	hours	hour	NOUN
bjp-19568	49	20	.	.	PUNCT
bjp-19568	50	1	after	after	ADP
bjp-19568	50	2	incubation	incubation	NOUN
bjp-19568	50	3	,	,	PUNCT
bjp-19568	50	4	cells	cell	NOUN
bjp-19568	50	5	were	be	AUX
bjp-19568	50	6	lysed	lyse	VERB
bjp-19568	50	7	and	and	CCONJ
bjp-19568	50	8	protein	protein	NOUN
bjp-19568	50	9	concentrations	concentration	NOUN
bjp-19568	50	10	were	be	AUX
bjp-19568	50	11	determined	determine	VERB
bjp-19568	50	12	by	by	ADP
bjp-19568	50	13	lowry	lowry	PROPN
bjp-19568	50	14	method	method	NOUN
bjp-19568	50	15	.	.	PUNCT
bjp-19568	51	1	cell	cell	NOUN
bjp-19568	51	2	samples	sample	NOUN
bjp-19568	51	3	were	be	AUX
bjp-19568	51	4	lysed	lyse	VERB
bjp-19568	51	5	in	in	ADP
bjp-19568	51	6	sample	sample	NOUN
bjp-19568	51	7	buffer	buffer	NOUN
bjp-19568	51	8	(	(	PUNCT
bjp-19568	51	9	150	150	NUM
bjp-19568	51	10	mm	mm	NOUN
bjp-19568	51	11	tris	tris	NOUN
bjp-19568	51	12	ph	ph	VERB
bjp-19568	51	13	6.8	6.8	NUM
bjp-19568	51	14	,	,	PUNCT
bjp-19568	51	15	8	8	NUM
bjp-19568	51	16	m	m	NOUN
bjp-19568	51	17	urea	urea	NOUN
bjp-19568	51	18	,	,	PUNCT
bjp-19568	51	19	50	50	NUM
bjp-19568	51	20	mm	mm	NUM
bjp-19568	51	21	dtt	dtt	NOUN
bjp-19568	51	22	,	,	PUNCT
bjp-19568	51	23	2	2	NUM
bjp-19568	51	24	%	%	NOUN
bjp-19568	51	25	sodium	sodium	NOUN
bjp-19568	51	26	dodecyl	dodecyl	NOUN
bjp-19568	51	27	sulfate	sulfate	NOUN
bjp-19568	51	28	,	,	PUNCT
bjp-19568	51	29	15	15	NUM
bjp-19568	51	30	%	%	NOUN
bjp-19568	51	31	sucrose	sucrose	NOUN
bjp-19568	51	32	,	,	PUNCT
bjp-19568	51	33	2	2	NUM
bjp-19568	51	34	mm	mm	NUM
bjp-19568	51	35	edta	edta	NOUN
bjp-19568	51	36	,	,	PUNCT
bjp-19568	51	37	0.01	0.01	NUM
bjp-19568	51	38	%	%	NOUN
bjp-19568	51	39	bromophenol	bromophenol	NOUN
bjp-19568	51	40	blue	blue	NOUN
bjp-19568	51	41	,	,	PUNCT
bjp-19568	51	42	and	and	CCONJ
bjp-19568	51	43	1	1	NUM
bjp-19568	51	44	%	%	NOUN
bjp-19568	51	45	protease	protease	NOUN
bjp-19568	51	46	and	and	CCONJ
bjp-19568	51	47	phosphatase	phosphatase	NOUN
bjp-19568	51	48	inhibitor	inhibitor	NOUN
bjp-19568	51	49	cocktails	cocktail	NOUN
bjp-19568	51	50	)	)	PUNCT
bjp-19568	51	51	,	,	PUNCT
bjp-19568	51	52	sonicated	sonicate	VERB
bjp-19568	51	53	and	and	CCONJ
bjp-19568	51	54	protein	protein	NOUN
bjp-19568	51	55	concentrations	concentration	NOUN
bjp-19568	51	56	were	be	AUX
bjp-19568	51	57	determined	determine	VERB
bjp-19568	51	58	by	by	ADP
bjp-19568	51	59	lowry	lowry	PROPN
bjp-19568	51	60	method	method	NOUN
bjp-19568	51	61	.	.	PUNCT
bjp-19568	52	1	the	the	DET
bjp-19568	52	2	samples	sample	NOUN
bjp-19568	52	3	(	(	PUNCT
bjp-19568	52	4	40	40	NUM
bjp-19568	52	5	-	-	SYM
bjp-19568	52	6	45	45	NUM
bjp-19568	52	7	μg	μg	NOUN
bjp-19568	52	8	)	)	PUNCT
bjp-19568	52	9	were	be	AUX
bjp-19568	52	10	boiled	boil	VERB
bjp-19568	52	11	,	,	PUNCT
bjp-19568	52	12	run	run	VERB
bjp-19568	52	13	through	through	ADP
bjp-19568	52	14	an	an	DET
bjp-19568	52	15	8	8	NUM
bjp-19568	52	16	-	-	SYM
bjp-19568	52	17	12	12	NUM
bjp-19568	52	18	%	%	NOUN
bjp-19568	52	19	bis	bis	ADJ
bjp-19568	52	20	/	/	SYM
bjp-19568	52	21	tris	tris	ADJ
bjp-19568	52	22	gel	gel	NOUN
bjp-19568	52	23	using	use	VERB
bjp-19568	52	24	5×	5×	PROPN
bjp-19568	52	25	mes	me	NOUN
bjp-19568	52	26	buffer	buffer	NOUN
bjp-19568	52	27	(	(	PUNCT
bjp-19568	52	28	invitrogen	invitrogen	PROPN
bjp-19568	52	29	)	)	PUNCT
bjp-19568	52	30	,	,	PUNCT
bjp-19568	52	31	transferred	transfer	VERB
bjp-19568	52	32	to	to	ADP
bjp-19568	52	33	an	an	DET
bjp-19568	52	34	immobilon	immobilon	NOUN
bjp-19568	52	35	nc	nc	PROPN
bjp-19568	52	36	membrane	membrane	PROPN
bjp-19568	52	37	(	(	PUNCT
bjp-19568	52	38	millipore	millipore	PROPN
bjp-19568	52	39	)	)	PUNCT
bjp-19568	52	40	and	and	CCONJ
bjp-19568	52	41	blocked	block	VERB
bjp-19568	52	42	in	in	ADP
bjp-19568	52	43	5	5	NUM
bjp-19568	52	44	%	%	NOUN
bjp-19568	52	45	non	non	ADJ
bjp-19568	52	46	-	-	ADJ
bjp-19568	52	47	fat	fat	ADJ
bjp-19568	52	48	milk	milk	NOUN
bjp-19568	52	49	in	in	ADP
bjp-19568	52	50	tbst	tbst	PROPN
bjp-19568	52	51	(	(	PUNCT
bjp-19568	52	52	150	150	NUM
bjp-19568	52	53	mm	mm	NOUN
bjp-19568	52	54	nacl	nacl	NOUN
bjp-19568	52	55	,	,	PUNCT
bjp-19568	52	56	50	50	NUM
bjp-19568	52	57	mm	mm	NOUN
bjp-19568	52	58	tris	tris	NOUN
bjp-19568	52	59	ph	ph	VERB
bjp-19568	52	60	7.5	7.5	NUM
bjp-19568	52	61	,	,	PUNCT
bjp-19568	52	62	and	and	CCONJ
bjp-19568	52	63	0.1	0.1	NUM
bjp-19568	52	64	%	%	NOUN
bjp-19568	52	65	tween-20	tween-20	NUM
bjp-19568	52	66	)	)	PUNCT
bjp-19568	52	67	.	.	PUNCT
bjp-19568	53	1	the	the	DET
bjp-19568	53	2	membranes	membrane	NOUN
bjp-19568	53	3	were	be	AUX
bjp-19568	53	4	then	then	ADV
bjp-19568	53	5	incubated	incubate	VERB
bjp-19568	53	6	with	with	ADP
bjp-19568	53	7	appropriate	appropriate	ADJ
bjp-19568	53	8	primary	primary	ADJ
bjp-19568	53	9	antibodies	antibody	NOUN
bjp-19568	53	10	(	(	PUNCT
bjp-19568	53	11	notch-1	notch-1	PROPN
bjp-19568	53	12	,	,	PUNCT
bjp-19568	53	13	hes-1	hes-1	PRON
bjp-19568	53	14	,	,	PUNCT
bjp-19568	53	15	cyclin	cyclin	NOUN
bjp-19568	53	16	d1,mmp-2	d1,mmp-2	PROPN
bjp-19568	53	17	and	and	CCONJ
bjp-19568	53	18	mmp-9	mmp-9	NUM
bjp-19568	53	19	)	)	PUNCT
bjp-19568	53	20	,	,	PUNCT
bjp-19568	53	21	followed	follow	VERB
bjp-19568	53	22	by	by	ADP
bjp-19568	53	23	incubation	incubation	NOUN
bjp-19568	53	24	with	with	ADP
bjp-19568	53	25	horseradish	horseradish	ADJ
bjp-19568	53	26	peroxidase	peroxidase	NOUN
bjp-19568	53	27	conjugated	conjugate	VERB
bjp-19568	53	28	anti	anti	ADJ
bjp-19568	53	29	-	-	ADJ
bjp-19568	53	30	rabbit	rabbit	ADJ
bjp-19568	53	31	igg	igg	PROPN
bjp-19568	53	32	(	(	PUNCT
bjp-19568	53	33	1:5000	1:5000	NUM
bjp-19568	53	34	)	)	PUNCT
bjp-19568	53	35	in	in	ADP
bjp-19568	53	36	blocking	block	VERB
bjp-19568	53	37	buffer	buffer	NOUN
bjp-19568	53	38	at	at	ADP
bjp-19568	53	39	room	room	NOUN
bjp-19568	53	40	temperature	temperature	NOUN
bjp-19568	53	41	for	for	ADP
bjp-19568	53	42	90	90	NUM
bjp-19568	53	43	min	min	NOUN
bjp-19568	53	44	,	,	PUNCT
bjp-19568	53	45	followed	follow	VERB
bjp-19568	53	46	by	by	ADP
bjp-19568	53	47	washing	washing	NOUN
bjp-19568	53	48	.	.	PUNCT
bjp-19568	54	1	immunoreactive	immunoreactive	ADJ
bjp-19568	54	2	bands	band	NOUN
bjp-19568	54	3	were	be	AUX
bjp-19568	54	4	detected	detect	VERB
bjp-19568	54	5	by	by	ADP
bjp-19568	54	6	enhanced	enhanced	ADJ
bjp-19568	54	7	chemiluminescence	chemiluminescence	NOUN
bjp-19568	54	8	(	(	PUNCT
bjp-19568	54	9	ge	ge	PROPN
bjp-19568	54	10	healthcare	healthcare	PROPN
bjp-19568	54	11	,	,	PUNCT
bjp-19568	54	12	uk	uk	PROPN
bjp-19568	54	13	)	)	PUNCT
bjp-19568	54	14	.	.	PUNCT
bjp-19568	55	1	real	real	ADJ
bjp-19568	55	2	-	-	PUNCT
bjp-19568	55	3	time	time	NOUN
bjp-19568	55	4	pcr	pcr	PROPN
bjp-19568	55	5	assay	assay	PROPN
bjp-19568	55	6	rt	rt	PROPN
bjp-19568	55	7	-	-	PUNCT
bjp-19568	55	8	pcr	pcr	PROPN
bjp-19568	55	9	is	be	AUX
bjp-19568	55	10	carried	carry	VERB
bjp-19568	55	11	out	out	ADP
bjp-19568	55	12	to	to	PART
bjp-19568	55	13	analyse	analyse	VERB
bjp-19568	55	14	the	the	DET
bjp-19568	55	15	change	change	NOUN
bjp-19568	55	16	at	at	ADP
bjp-19568	55	17	the	the	DET
bjp-19568	55	18	transcriptional	transcriptional	ADJ
bjp-19568	55	19	levels	level	NOUN
bjp-19568	55	20	.	.	PUNCT
bjp-19568	56	1	briefly	briefly	NOUN
bjp-19568	56	2	,	,	PUNCT
bjp-19568	56	3	mg-63	mg-63	NOUN
bjp-19568	56	4	and	and	CCONJ
bjp-19568	56	5	u2os	u2o	VERB
bjp-19568	56	6	cancer	cancer	NOUN
bjp-19568	56	7	cells	cell	NOUN
bjp-19568	56	8	are	be	AUX
bjp-19568	56	9	treated	treat	VERB
bjp-19568	56	10	with	with	ADP
bjp-19568	56	11	20	20	NUM
bjp-19568	56	12	µm	µm	NOUN
bjp-19568	56	13	wa	wa	NOUN
bjp-19568	56	14	for	for	ADP
bjp-19568	56	15	12	12	NUM
bjp-19568	56	16	hours	hour	NOUN
bjp-19568	56	17	.	.	PUNCT
bjp-19568	57	1	trizol	trizol	VERB
bjp-19568	57	2	reagents	reagent	NOUN
bjp-19568	57	3	(	(	PUNCT
bjp-19568	57	4	invitrogen	invitrogen	PROPN
bjp-19568	57	5	,	,	PUNCT
bjp-19568	57	6	carlsbad	carlsbad	PROPN
bjp-19568	57	7	,	,	PUNCT
bjp-19568	57	8	ca	ca	NOUN
bjp-19568	57	9	)	)	PUNCT
bjp-19568	57	10	are	be	AUX
bjp-19568	57	11	used	use	VERB
bjp-19568	57	12	to	to	PART
bjp-19568	57	13	extract	extract	VERB
bjp-19568	57	14	total	total	ADJ
bjp-19568	57	15	cellular	cellular	ADJ
bjp-19568	57	16	rnas	rna	NOUN
bjp-19568	57	17	as	as	SCONJ
bjp-19568	57	18	described	describe	VERB
bjp-19568	57	19	in	in	ADP
bjp-19568	57	20	protocol	protocol	NOUN
bjp-19568	57	21	provided	provide	VERB
bjp-19568	57	22	by	by	ADP
bjp-19568	57	23	manufacturer	manufacturer	NOUN
bjp-19568	57	24	.	.	PUNCT
bjp-19568	58	1	superscript	superscript	PROPN
bjp-19568	58	2	iii	iii	PROPN
bjp-19568	58	3	first	first	ADJ
bjp-19568	58	4	strand	strand	NOUN
bjp-19568	58	5	synthesis	synthesis	NOUN
bjp-19568	58	6	kit	kit	NOUN
bjp-19568	58	7	from	from	ADP
bjp-19568	58	8	invitrogen	invitrogen	PROPN
bjp-19568	58	9	is	be	AUX
bjp-19568	58	10	used	use	VERB
bjp-19568	58	11	to	to	PART
bjp-19568	58	12	reverse	reverse	VERB
bjp-19568	58	13	transcribe	transcribe	VERB
bjp-19568	58	14	the	the	DET
bjp-19568	58	15	cdna	cdna	PROPN
bjp-19568	58	16	.	.	PUNCT
bjp-19568	59	1	then	then	ADV
bjp-19568	59	2	the	the	DET
bjp-19568	59	3	real	real	ADJ
bjp-19568	59	4	-	-	PUNCT
bjp-19568	59	5	time	time	NOUN
bjp-19568	59	6	pcr	pcr	NOUN
bjp-19568	59	7	is	be	AUX
bjp-19568	59	8	carried	carry	VERB
bjp-19568	59	9	out	out	ADP
bjp-19568	59	10	in	in	ADP
bjp-19568	59	11	abi	abi	PROPN
bjp-19568	59	12	prism	prism	NOUN
bjp-19568	59	13	7900	7900	NUM
bjp-19568	59	14	t	t	NOUN
bjp-19568	59	15	real	real	ADJ
bjp-19568	59	16	-	-	PUNCT
bjp-19568	59	17	time	time	NOUN
bjp-19568	59	18	pcr	pcr	NOUN
bjp-19568	59	19	system	system	NOUN
bjp-19568	59	20	(	(	PUNCT
bjp-19568	59	21	perkinelmer	perkinelmer	NOUN
bjp-19568	59	22	,	,	PUNCT
bjp-19568	59	23	branchburg	branchburg	PROPN
bjp-19568	59	24	,	,	PUNCT
bjp-19568	59	25	nj	nj	PROPN
bjp-19568	59	26	)	)	PUNCT
bjp-19568	59	27	with	with	ADP
bjp-19568	59	28	sybr	sybr	PROPN
bjp-19568	59	29	green	green	ADJ
bjp-19568	59	30	pcr	pcr	PROPN
bjp-19568	59	31	master	master	NOUN
bjp-19568	59	32	mix	mix	NOUN
bjp-19568	59	33	(	(	PUNCT
bjp-19568	59	34	applied	apply	VERB
bjp-19568	59	35	biosystems	biosystem	NOUN
bjp-19568	59	36	,	,	PUNCT
bjp-19568	59	37	usa	usa	PROPN
bjp-19568	59	38	)	)	PUNCT
bjp-19568	59	39	.	.	PUNCT
bjp-19568	60	1	the	the	DET
bjp-19568	60	2	primers	primer	NOUN
bjp-19568	60	3	bangladesh	bangladesh	PROPN
bjp-19568	60	4	j	j	PROPN
bjp-19568	60	5	pharmacol	pharmacol	PROPN
bjp-19568	60	6	2014	2014	NUM
bjp-19568	60	7	;	;	PUNCT
bjp-19568	60	8	9	9	NUM
bjp-19568	60	9	:	:	SYM
bjp-19568	60	10	364	364	NUM
bjp-19568	60	11	-	-	SYM
bjp-19568	60	12	370	370	NUM
bjp-19568	60	13	365	365	NUM
bjp-19568	60	14	used	use	VERB
bjp-19568	60	15	in	in	ADP
bjp-19568	60	16	rt	rt	PROPN
bjp-19568	60	17	-	-	PUNCT
bjp-19568	60	18	pcr	pcr	PROPN
bjp-19568	60	19	are	be	AUX
bjp-19568	60	20	shown	show	VERB
bjp-19568	60	21	in	in	ADP
bjp-19568	60	22	table	table	NOUN
bjp-19568	60	23	i.	i.	PROPN
bjp-19568	60	24	mrna	mrna	PROPN
bjp-19568	60	25	levels	level	NOUN
bjp-19568	60	26	are	be	AUX
bjp-19568	60	27	calculated	calculate	VERB
bjp-19568	60	28	as	as	ADP
bjp-19568	60	29	fold	fold	ADJ
bjp-19568	60	30	change	change	NOUN
bjp-19568	60	31	of	of	ADP
bjp-19568	60	32	control	control	NOUN
bjp-19568	60	33	.	.	PUNCT
bjp-19568	61	1	after	after	ADP
bjp-19568	61	2	completion	completion	NOUN
bjp-19568	61	3	of	of	ADP
bjp-19568	61	4	the	the	DET
bjp-19568	61	5	rt	rt	NOUN
bjp-19568	61	6	-	-	PUNCT
bjp-19568	61	7	pcr	pcr	PROPN
bjp-19568	61	8	,	,	PUNCT
bjp-19568	61	9	ct	ct	NUM
bjp-19568	61	10	values	value	NOUN
bjp-19568	61	11	(	(	PUNCT
bjp-19568	61	12	cycle	cycle	NOUN
bjp-19568	61	13	numbers	number	NOUN
bjp-19568	61	14	in	in	ADP
bjp-19568	61	15	which	which	DET
bjp-19568	61	16	signal	signal	NOUN
bjp-19568	61	17	intensity	intensity	NOUN
bjp-19568	61	18	equal	equal	ADJ
bjp-19568	61	19	to	to	ADP
bjp-19568	61	20	the	the	DET
bjp-19568	61	21	threshold	threshold	NOUN
bjp-19568	61	22	value	value	NOUN
bjp-19568	61	23	)	)	PUNCT
bjp-19568	61	24	will	will	AUX
bjp-19568	61	25	be	be	AUX
bjp-19568	61	26	obtained	obtain	VERB
bjp-19568	61	27	from	from	ADP
bjp-19568	61	28	the	the	DET
bjp-19568	61	29	software	software	NOUN
bjp-19568	61	30	.	.	PUNCT
bjp-19568	62	1	for	for	ADP
bjp-19568	62	2	each	each	DET
bjp-19568	62	3	samples	sample	NOUN
bjp-19568	62	4	,	,	PUNCT
bjp-19568	62	5	δct	δct	NOUN
bjp-19568	62	6	is	be	AUX
bjp-19568	62	7	calculated	calculate	VERB
bjp-19568	62	8	as	as	ADP
bjp-19568	62	9	δct	δct	NOUN
bjp-19568	62	10	=	=	SYM
bjp-19568	62	11	ctakt	ctakt	NOUN
bjp-19568	62	12	/	/	SYM
bjp-19568	62	13	cdk4	cdk4	NOUN
bjp-19568	62	14	/	/	SYM
bjp-19568	62	15	gr	gr	PROPN
bjp-19568	62	16	–	–	PUNCT
bjp-19568	62	17	ctactin	ctactin	NOUN
bjp-19568	62	18	.	.	PUNCT
bjp-19568	63	1	then	then	ADV
bjp-19568	63	2	δδct	δδct	NOUN
bjp-19568	63	3	is	be	AUX
bjp-19568	63	4	calculated	calculate	VERB
bjp-19568	63	5	as	as	ADP
bjp-19568	63	6	δδct	δδct	NOUN
bjp-19568	63	7	=	=	SYM
bjp-19568	63	8	δcttreatment	δcttreatment	NOUN
bjp-19568	63	9	δctcontrol	δctcontrol	NOUN
bjp-19568	63	10	.	.	PUNCT
bjp-19568	64	1	the	the	DET
bjp-19568	64	2	fold	fold	ADJ
bjp-19568	64	3	change	change	NOUN
bjp-19568	64	4	of	of	ADP
bjp-19568	64	5	the	the	DET
bjp-19568	64	6	akt	akt	PROPN
bjp-19568	64	7	/	/	SYM
bjp-19568	64	8	cdk4	cdk4	PROPN
bjp-19568	64	9	/	/	SYM
bjp-19568	64	10	gr	gr	PROPN
bjp-19568	64	11	mrna	mrna	PROPN
bjp-19568	64	12	levels	level	NOUN
bjp-19568	64	13	relative	relative	ADJ
bjp-19568	64	14	to	to	ADP
bjp-19568	64	15	control	control	NOUN
bjp-19568	64	16	group	group	NOUN
bjp-19568	64	17	are	be	AUX
bjp-19568	64	18	calculated	calculate	VERB
bjp-19568	64	19	as	as	ADP
bjp-19568	64	20	2	2	NUM
bjp-19568	64	21	-	-	PUNCT
bjp-19568	64	22	δδct	δδct	NOUN
bjp-19568	64	23	.	.	PUNCT
bjp-19568	65	1	statistical	statistical	ADJ
bjp-19568	65	2	analysis	analysis	NOUN
bjp-19568	65	3	all	all	DET
bjp-19568	65	4	experiments	experiment	NOUN
bjp-19568	65	5	were	be	AUX
bjp-19568	65	6	performed	perform	VERB
bjp-19568	65	7	in	in	ADP
bjp-19568	65	8	duplicate	duplicate	NOUN
bjp-19568	65	9	and	and	CCONJ
bjp-19568	65	10	repeated	repeat	VERB
bjp-19568	65	11	at	at	ADP
bjp-19568	65	12	least	least	ADV
bjp-19568	65	13	three	three	NUM
bjp-19568	65	14	times	time	NOUN
bjp-19568	65	15	.	.	PUNCT
bjp-19568	66	1	the	the	DET
bjp-19568	66	2	data	datum	NOUN
bjp-19568	66	3	are	be	AUX
bjp-19568	66	4	expressed	express	VERB
bjp-19568	66	5	as	as	ADP
bjp-19568	66	6	the	the	DET
bjp-19568	66	7	means	means	PROPN
bjp-19568	66	8	±	±	NUM
bjp-19568	66	9	standard	standard	ADJ
bjp-19568	66	10	deviation	deviation	NOUN
bjp-19568	66	11	(	(	PUNCT
bjp-19568	66	12	sd	sd	NOUN
bjp-19568	66	13	)	)	PUNCT
bjp-19568	66	14	.	.	PUNCT
bjp-19568	67	1	the	the	DET
bjp-19568	67	2	treatment	treatment	NOUN
bjp-19568	67	3	groups	group	NOUN
bjp-19568	67	4	were	be	AUX
bjp-19568	67	5	compared	compare	VERB
bjp-19568	67	6	by	by	ADP
bjp-19568	67	7	one	one	NUM
bjp-19568	67	8	-	-	PUNCT
bjp-19568	67	9	way	way	NOUN
bjp-19568	67	10	variance	variance	NOUN
bjp-19568	67	11	(	(	PUNCT
bjp-19568	67	12	anova	anova	PROPN
bjp-19568	67	13	)	)	PUNCT
bjp-19568	67	14	with	with	ADP
bjp-19568	67	15	spss	spss	PROPN
bjp-19568	67	16	12.0	12.0	NUM
bjp-19568	67	17	(	(	PUNCT
bjp-19568	67	18	spss	spss	PROPN
bjp-19568	67	19	inc	inc	PROPN
bjp-19568	67	20	.	.	PROPN
bjp-19568	67	21	,	,	PUNCT
bjp-19568	67	22	chicago	chicago	PROPN
bjp-19568	67	23	)	)	PUNCT
bjp-19568	67	24	.	.	PUNCT
bjp-19568	68	1	differences	difference	NOUN
bjp-19568	68	2	were	be	AUX
bjp-19568	68	3	considered	consider	VERB
bjp-19568	68	4	statistically	statistically	ADV
bjp-19568	68	5	significant	significant	ADJ
bjp-19568	68	6	at	at	ADP
bjp-19568	68	7	p<0.05	p<0.05	NOUN
bjp-19568	68	8	.	.	PUNCT
bjp-19568	69	1	results	result	VERB
bjp-19568	69	2	the	the	DET
bjp-19568	69	3	effect	effect	NOUN
bjp-19568	69	4	of	of	ADP
bjp-19568	69	5	a	a	DET
bjp-19568	69	6	drug	drug	NOUN
bjp-19568	69	7	can	can	AUX
bjp-19568	69	8	be	be	AUX
bjp-19568	69	9	cytotoxic	cytotoxic	ADJ
bjp-19568	69	10	or	or	CCONJ
bjp-19568	69	11	cytostatic	cytostatic	ADJ
bjp-19568	69	12	.	.	PUNCT
bjp-19568	70	1	in	in	ADP
bjp-19568	70	2	initial	initial	ADJ
bjp-19568	70	3	experiments	experiment	NOUN
bjp-19568	70	4	,	,	PUNCT
bjp-19568	70	5	the	the	DET
bjp-19568	70	6	cytotoxic	cytotoxic	ADJ
bjp-19568	70	7	effect	effect	NOUN
bjp-19568	70	8	of	of	ADP
bjp-19568	70	9	withaferin	withaferin	NOUN
bjp-19568	70	10	a	a	DET
bjp-19568	70	11	on	on	ADP
bjp-19568	70	12	osteosarcoma	osteosarcoma	ADJ
bjp-19568	70	13	cell	cell	NOUN
bjp-19568	70	14	lines	line	NOUN
bjp-19568	70	15	,	,	PUNCT
bjp-19568	70	16	namely	namely	ADV
bjp-19568	70	17	u2os	u2os	PUNCT
bjp-19568	70	18	,	,	PUNCT
bjp-19568	70	19	saos-2	saos-2	NUM
bjp-19568	70	20	and	and	CCONJ
bjp-19568	70	21	mg-63	mg-63	NOUN
bjp-19568	70	22	,	,	PUNCT
bjp-19568	70	23	was	be	AUX
bjp-19568	70	24	evaluated	evaluate	VERB
bjp-19568	70	25	using	use	VERB
bjp-19568	70	26	3-(4,5	3-(4,5	PROPN
bjp-19568	70	27	-	-	PUNCT
bjp-19568	70	28	dimethylthiazol-2	dimethylthiazol-2	NUM
bjp-19568	70	29	yl)-2,5	yl)-2,5	NOUN
bjp-19568	70	30	-	-	PUNCT
bjp-19568	70	31	diphenyltetrazolium	diphenyltetrazolium	NOUN
bjp-19568	70	32	bromide	bromide	NOUN
bjp-19568	70	33	(	(	PUNCT
bjp-19568	70	34	mtt	mtt	NOUN
bjp-19568	70	35	)	)	PUNCT
bjp-19568	70	36	assays	assay	NOUN
bjp-19568	70	37	.	.	PUNCT
bjp-19568	71	1	withaferin	withaferin	PROPN
bjp-19568	71	2	a	a	DET
bjp-19568	71	3	reduced	reduce	VERB
bjp-19568	71	4	the	the	DET
bjp-19568	71	5	proliferation	proliferation	NOUN
bjp-19568	71	6	of	of	ADP
bjp-19568	71	7	these	these	DET
bjp-19568	71	8	cells	cell	NOUN
bjp-19568	71	9	in	in	ADP
bjp-19568	71	10	a	a	DET
bjp-19568	71	11	dose	dose	NOUN
bjp-19568	71	12	-	-	PUNCT
bjp-19568	71	13	dependent	dependent	ADJ
bjp-19568	71	14	manner	manner	NOUN
bjp-19568	71	15	(	(	PUNCT
bjp-19568	71	16	figure	figure	NOUN
bjp-19568	71	17	1	1	NUM
bjp-19568	71	18	)	)	PUNCT
bjp-19568	71	19	.	.	PUNCT
bjp-19568	72	1	the	the	DET
bjp-19568	72	2	half	half	ADV
bjp-19568	72	3	-	-	PUNCT
bjp-19568	72	4	maximal	maximal	ADJ
bjp-19568	72	5	inhibitory	inhibitory	ADJ
bjp-19568	72	6	concentration	concentration	NOUN
bjp-19568	72	7	(	(	PUNCT
bjp-19568	72	8	ic50	ic50	PROPN
bjp-19568	72	9	)	)	PUNCT
bjp-19568	72	10	of	of	ADP
bjp-19568	72	11	withaferin	withaferin	NOUN
bjp-19568	72	12	a	a	PRON
bjp-19568	72	13	at	at	ADP
bjp-19568	72	14	72	72	NUM
bjp-19568	72	15	hours	hour	NOUN
bjp-19568	72	16	was	be	AUX
bjp-19568	72	17	found	find	VERB
bjp-19568	72	18	to	to	PART
bjp-19568	72	19	be	be	AUX
bjp-19568	72	20	20.1	20.1	NUM
bjp-19568	72	21	±	±	NUM
bjp-19568	72	22	1.2	1.2	NUM
bjp-19568	72	23	,	,	PUNCT
bjp-19568	72	24	20.0	20.0	NUM
bjp-19568	72	25	±	±	NUM
bjp-19568	72	26	1.1	1.1	NUM
bjp-19568	72	27	and	and	CCONJ
bjp-19568	72	28	21.7	21.7	NUM
bjp-19568	72	29	±	±	NUM
bjp-19568	72	30	1.2	1.2	NUM
bjp-19568	72	31	µm	µm	NOUN
bjp-19568	72	32	in	in	ADP
bjp-19568	72	33	u2os	u2o	NOUN
bjp-19568	72	34	,	,	PUNCT
bjp-19568	72	35	saos-2	saos-2	NUM
bjp-19568	72	36	and	and	CCONJ
bjp-19568	72	37	mg-63	mg-63	NOUN
bjp-19568	72	38	cells	cell	NOUN
bjp-19568	72	39	,	,	PUNCT
bjp-19568	72	40	respectively	respectively	ADV
bjp-19568	72	41	.	.	PUNCT
bjp-19568	73	1	to	to	PART
bjp-19568	73	2	determine	determine	VERB
bjp-19568	73	3	an	an	DET
bjp-19568	73	4	optimum	optimum	ADJ
bjp-19568	73	5	(	(	PUNCT
bjp-19568	73	6	effective	effective	ADJ
bjp-19568	73	7	yet	yet	CCONJ
bjp-19568	73	8	non	non	ADJ
bjp-19568	73	9	-	-	ADJ
bjp-19568	73	10	toxic	toxic	ADJ
bjp-19568	73	11	)	)	PUNCT
bjp-19568	73	12	dose	dose	NOUN
bjp-19568	73	13	range	range	NOUN
bjp-19568	73	14	for	for	ADP
bjp-19568	73	15	subsequent	subsequent	ADJ
bjp-19568	73	16	studies	study	NOUN
bjp-19568	73	17	,	,	PUNCT
bjp-19568	73	18	time	time	NOUN
bjp-19568	73	19	response	response	NOUN
bjp-19568	73	20	cytotoxic	cytotoxic	ADJ
bjp-19568	73	21	assays	assay	NOUN
bjp-19568	73	22	were	be	AUX
bjp-19568	73	23	performed	perform	VERB
bjp-19568	73	24	next	next	ADV
bjp-19568	73	25	.	.	PUNCT
bjp-19568	74	1	our	our	PRON
bjp-19568	74	2	data	datum	NOUN
bjp-19568	74	3	showed	show	VERB
bjp-19568	74	4	that	that	SCONJ
bjp-19568	74	5	treatment	treatment	NOUN
bjp-19568	74	6	of	of	ADP
bjp-19568	74	7	osteosarcoma	osteosarcoma	ADJ
bjp-19568	74	8	cells	cell	NOUN
bjp-19568	74	9	with	with	ADP
bjp-19568	74	10	withaferin	withaferin	PROPN
bjp-19568	74	11	a	a	DET
bjp-19568	74	12	beyond	beyond	ADJ
bjp-19568	74	13	30	30	NUM
bjp-19568	74	14	µm	µm	NOUN
bjp-19568	74	15	at	at	ADP
bjp-19568	74	16	24	24	NUM
bjp-19568	74	17	,	,	PUNCT
bjp-19568	74	18	48	48	NUM
bjp-19568	74	19	and	and	CCONJ
bjp-19568	74	20	72	72	NUM
bjp-19568	74	21	hours	hour	NOUN
bjp-19568	74	22	resulted	result	VERB
bjp-19568	74	23	in	in	ADP
bjp-19568	74	24	statistically	statistically	ADV
bjp-19568	74	25	significant	significant	ADJ
bjp-19568	74	26	toxicities	toxicity	NOUN
bjp-19568	74	27	and	and	CCONJ
bjp-19568	74	28	hence	hence	ADV
bjp-19568	74	29	the	the	DET
bjp-19568	74	30	maximum	maximum	ADJ
bjp-19568	74	31	concentration	concentration	NOUN
bjp-19568	74	32	employed	employ	VERB
bjp-19568	74	33	in	in	ADP
bjp-19568	74	34	subsequent	subsequent	ADJ
bjp-19568	74	35	studies	study	NOUN
bjp-19568	74	36	was	be	AUX
bjp-19568	74	37	limited	limit	VERB
bjp-19568	74	38	to	to	ADP
bjp-19568	74	39	20	20	NUM
bjp-19568	74	40	µm	µm	NOUN
bjp-19568	74	41	(	(	PUNCT
bjp-19568	74	42	figure	figure	NOUN
bjp-19568	74	43	1	1	NUM
bjp-19568	74	44	)	)	PUNCT
bjp-19568	74	45	.	.	PUNCT
bjp-19568	75	1	as	as	SCONJ
bjp-19568	75	2	discussed	discuss	VERB
bjp-19568	75	3	above	above	ADV
bjp-19568	75	4	,	,	PUNCT
bjp-19568	75	5	treatment	treatment	NOUN
bjp-19568	75	6	of	of	ADP
bjp-19568	75	7	u2os	u2o	NOUN
bjp-19568	75	8	,	,	PUNCT
bjp-19568	75	9	saos-2	saos-2	NUM
bjp-19568	75	10	and	and	CCONJ
bjp-19568	75	11	mg-63	mg-63	NOUN
bjp-19568	75	12	cells	cell	NOUN
bjp-19568	75	13	with	with	ADP
bjp-19568	75	14	increasing	increase	VERB
bjp-19568	75	15	concentrations	concentration	NOUN
bjp-19568	75	16	of	of	ADP
bjp-19568	75	17	withaferin	withaferin	PROPN
bjp-19568	75	18	a	a	DET
bjp-19568	75	19	resulted	result	VERB
bjp-19568	75	20	in	in	ADP
bjp-19568	75	21	a	a	DET
bjp-19568	75	22	dose	dose	NOUN
bjp-19568	75	23	-	-	PUNCT
bjp-19568	75	24	dependent	dependent	ADJ
bjp-19568	75	25	decrease	decrease	NOUN
bjp-19568	75	26	in	in	ADP
bjp-19568	75	27	viable	viable	ADJ
bjp-19568	75	28	366	366	NUM
bjp-19568	75	29	bangladesh	bangladesh	NOUN
bjp-19568	75	30	j	j	PROPN
bjp-19568	75	31	pharmacol	pharmacol	PROPN
bjp-19568	75	32	2014	2014	NUM
bjp-19568	75	33	;	;	PUNCT
bjp-19568	75	34	9	9	NUM
bjp-19568	75	35	:	:	SYM
bjp-19568	75	36	364	364	NUM
bjp-19568	75	37	-	-	SYM
bjp-19568	75	38	370	370	NUM
bjp-19568	75	39	table	table	NOUN
bjp-19568	75	40	i	i	PRON
bjp-19568	75	41	primer	primer	VERB
bjp-19568	75	42	sequences	sequence	NOUN
bjp-19568	75	43	used	use	VERB
bjp-19568	75	44	in	in	ADP
bjp-19568	75	45	rt	rt	ADJ
bjp-19568	75	46	-	-	PUNCT
bjp-19568	75	47	pcr	pcr	NOUN
bjp-19568	75	48	analysis	analysis	NOUN
bjp-19568	75	49	gene	gene	NOUN
bjp-19568	76	1	forward	forward	ADV
bjp-19568	76	2	primes	prime	NOUN
bjp-19568	76	3	(	(	PUNCT
bjp-19568	76	4	5’-3	5’-3	NOUN
bjp-19568	76	5	’	'	PUNCT
bjp-19568	76	6	)	)	PUNCT
bjp-19568	76	7	reverse	reverse	ADJ
bjp-19568	76	8	primes	prime	NOUN
bjp-19568	76	9	(	(	PUNCT
bjp-19568	76	10	5’-3	5’-3	NOUN
bjp-19568	76	11	’	'	PUNCT
bjp-19568	76	12	)	)	PUNCT
bjp-19568	77	1	notch-1	notch-1	PROPN
bjp-19568	77	2	:	:	PUNCT
bjp-19568	77	3	tcagcgggatccactgtgag	tcagcgggatccactgtgag	ADJ
bjp-19568	77	4	acacaggcaggtgaacgagttg	acacaggcaggtgaacgagttg	NOUN
bjp-19568	77	5	hes-1	hes-1	AUX
bjp-19568	77	6	:	:	PUNCT
bjp-19568	77	7	gagcacagaaagtcatcaaagc	gagcacagaaagtcatcaaagc	NOUN
bjp-19568	77	8	atttccagaatgtccgccttc	atttccagaatgtccgccttc	ADJ
bjp-19568	77	9	hey-1	hey-1	NOUN
bjp-19568	77	10	cggagaggaataattgagaagcg	cggagaggaataattgagaagcg	NOUN
bjp-19568	77	11	ctttccctcctgccgtatgc	ctttccctcctgccgtatgc	VERB
bjp-19568	77	12	hey-2	hey-2	PUNCT
bjp-19568	77	13	ttcaaggcagctcggtaact	ttcaaggcagctcggtaact	NOUN
bjp-19568	77	14	gggcattttacttccccaat	gggcattttacttccccaat	PROPN
bjp-19568	77	15	mmp-2	mmp-2	DET
bjp-19568	77	16	cagggaatgaatactggatctact	cagggaatgaatactggatctact	ADJ
bjp-19568	77	17	gctccagttaaaggcggcatccac	gctccagttaaaggcggcatccac	PROPN
bjp-19568	77	18	mmp-9	mmp-9	NOUN
bjp-19568	77	19	gcctgcaacgtgaacatct	gcctgcaacgtgaacatct	NOUN
bjp-19568	77	20	tcaaagaccgagtccagctt	tcaaagaccgagtccagctt	NOUN
bjp-19568	77	21	gapdh	gapdh	NOUN
bjp-19568	77	22	gcaccgtcaaggctgagaac	gcaccgtcaaggctgagaac	NOUN
bjp-19568	77	23	tggtgaagacgccagtgga	tggtgaagacgccagtgga	NOUN
bjp-19568	77	24	figure	figure	NOUN
bjp-19568	77	25	1	1	NUM
bjp-19568	77	26	:	:	PUNCT
bjp-19568	77	27	effect	effect	NOUN
bjp-19568	77	28	of	of	ADP
bjp-19568	77	29	withaferin	withaferin	NOUN
bjp-19568	77	30	a	a	PRON
bjp-19568	77	31	on	on	ADP
bjp-19568	77	32	osteosarcoma	osteosarcoma	ADJ
bjp-19568	77	33	cell	cell	NOUN
bjp-19568	77	34	viability	viability	NOUN
bjp-19568	77	35	was	be	AUX
bjp-19568	77	36	tested	test	VERB
bjp-19568	77	37	by	by	ADP
bjp-19568	77	38	mtt	mtt	PROPN
bjp-19568	77	39	assay	assay	X
bjp-19568	77	40	u2os	u2os	PUNCT
bjp-19568	77	41	,	,	PUNCT
bjp-19568	77	42	saos-2	saos-2	NUM
bjp-19568	77	43	and	and	CCONJ
bjp-19568	77	44	mg-63	mg-63	NOUN
bjp-19568	77	45	cells	cell	NOUN
bjp-19568	77	46	were	be	AUX
bjp-19568	77	47	treated	treat	VERB
bjp-19568	77	48	with	with	ADP
bjp-19568	77	49	various	various	ADJ
bjp-19568	77	50	concentrations	concentration	NOUN
bjp-19568	77	51	of	of	ADP
bjp-19568	77	52	withaferin	withaferin	NOUN
bjp-19568	77	53	a	a	PRON
bjp-19568	77	54	for	for	ADP
bjp-19568	77	55	24	24	NUM
bjp-19568	77	56	,	,	PUNCT
bjp-19568	77	57	48	48	NUM
bjp-19568	77	58	or	or	CCONJ
bjp-19568	77	59	72	72	NUM
bjp-19568	77	60	hours	hour	NOUN
bjp-19568	77	61	(	(	PUNCT
bjp-19568	77	62	control	control	NOUN
bjp-19568	77	63	:	:	PUNCT
bjp-19568	77	64	cells	cell	NOUN
bjp-19568	77	65	treated	treat	VERB
bjp-19568	77	66	with	with	ADP
bjp-19568	77	67	dimethylsulfoxide	dimethylsulfoxide	ADJ
bjp-19568	77	68	)	)	PUNCT
bjp-19568	77	69	.	.	PUNCT
bjp-19568	78	1	mtt	mtt	NOUN
bjp-19568	78	2	assays	assay	NOUN
bjp-19568	78	3	were	be	AUX
bjp-19568	78	4	used	use	VERB
bjp-19568	78	5	to	to	PART
bjp-19568	78	6	establish	establish	VERB
bjp-19568	78	7	an	an	DET
bjp-19568	78	8	optimum	optimum	ADJ
bjp-19568	78	9	concentration	concentration	NOUN
bjp-19568	78	10	range	range	NOUN
bjp-19568	78	11	of	of	ADP
bjp-19568	78	12	withaferin	withaferin	NOUN
bjp-19568	78	13	a	a	PRON
bjp-19568	78	14	for	for	ADP
bjp-19568	78	15	subsequent	subsequent	ADJ
bjp-19568	78	16	experiments	experiment	NOUN
bjp-19568	78	17	.	.	PUNCT
bjp-19568	79	1	treatment	treatment	NOUN
bjp-19568	79	2	of	of	ADP
bjp-19568	79	3	osteosarcoma	osteosarcoma	ADJ
bjp-19568	79	4	cells	cell	NOUN
bjp-19568	79	5	with	with	ADP
bjp-19568	79	6	withaferin	withaferin	PROPN
bjp-19568	79	7	a	a	DET
bjp-19568	79	8	resulted	result	VERB
bjp-19568	79	9	in	in	ADP
bjp-19568	79	10	cell	cell	NOUN
bjp-19568	79	11	viability	viability	NOUN
bjp-19568	79	12	inhibition	inhibition	NOUN
bjp-19568	79	13	in	in	ADP
bjp-19568	79	14	a	a	DET
bjp-19568	79	15	doseand	doseand	ADJ
bjp-19568	79	16	time	time	NOUN
bjp-19568	79	17	-	-	PUNCT
bjp-19568	79	18	dependent	dependent	ADJ
bjp-19568	79	19	manner	manner	NOUN
bjp-19568	79	20	.	.	PUNCT
bjp-19568	80	1	treatment	treatment	NOUN
bjp-19568	80	2	of	of	ADP
bjp-19568	80	3	osteosarcoma	osteosarcoma	ADJ
bjp-19568	80	4	cells	cell	NOUN
bjp-19568	80	5	with	with	ADP
bjp-19568	80	6	withaferin	withaferin	PROPN
bjp-19568	80	7	a	a	DET
bjp-19568	80	8	beyond	beyond	ADJ
bjp-19568	80	9	30	30	NUM
bjp-19568	80	10	µm	µm	NOUN
bjp-19568	80	11	at	at	ADP
bjp-19568	80	12	24	24	NUM
bjp-19568	80	13	,	,	PUNCT
bjp-19568	80	14	48	48	NUM
bjp-19568	80	15	and	and	CCONJ
bjp-19568	80	16	72	72	NUM
bjp-19568	80	17	hours	hour	NOUN
bjp-19568	80	18	resulted	result	VERB
bjp-19568	80	19	in	in	ADP
bjp-19568	80	20	statistically	statistically	ADV
bjp-19568	80	21	significant	significant	ADJ
bjp-19568	80	22	toxicities	toxicity	NOUN
bjp-19568	80	23	.	.	PUNCT
bjp-19568	81	1	cell	cell	NOUN
bjp-19568	81	2	viability	viability	NOUN
bjp-19568	81	3	in	in	ADP
bjp-19568	81	4	withaferin	withaferin	PROPN
bjp-19568	81	5	a	a	PROPN
bjp-19568	81	6	-	-	PUNCT
bjp-19568	81	7	treated	treat	VERB
bjp-19568	81	8	cells	cell	NOUN
bjp-19568	81	9	was	be	AUX
bjp-19568	81	10	expressed	express	VERB
bjp-19568	81	11	as	as	ADP
bjp-19568	81	12	the	the	DET
bjp-19568	81	13	percentage	percentage	NOUN
bjp-19568	81	14	of	of	ADP
bjp-19568	81	15	dimethylsulfoxide	dimethylsulfoxide	ADV
bjp-19568	81	16	–	–	PUNCT
bjp-19568	81	17	treated	treat	VERB
bjp-19568	81	18	samples	sample	NOUN
bjp-19568	81	19	.	.	PUNCT
bjp-19568	82	1	results	result	NOUN
bjp-19568	82	2	represent	represent	VERB
bjp-19568	82	3	the	the	DET
bjp-19568	82	4	mean	mean	ADJ
bjp-19568	82	5	±	±	NUM
bjp-19568	82	6	sd	sd	NOUN
bjp-19568	82	7	of	of	ADP
bjp-19568	82	8	three	three	NUM
bjp-19568	82	9	individual	individual	ADJ
bjp-19568	82	10	experiments	experiment	NOUN
bjp-19568	82	11	having	have	VERB
bjp-19568	82	12	six	six	NUM
bjp-19568	82	13	determinations	determination	NOUN
bjp-19568	82	14	per	per	ADP
bjp-19568	82	15	experiment	experiment	NOUN
bjp-19568	82	16	for	for	ADP
bjp-19568	82	17	each	each	DET
bjp-19568	82	18	experimental	experimental	ADJ
bjp-19568	82	19	condition	condition	NOUN
bjp-19568	82	20	cells	cell	NOUN
bjp-19568	82	21	and	and	CCONJ
bjp-19568	82	22	thus	thus	ADV
bjp-19568	82	23	indicated	indicate	VERB
bjp-19568	82	24	a	a	DET
bjp-19568	82	25	cytotoxic	cytotoxic	ADJ
bjp-19568	82	26	effect	effect	NOUN
bjp-19568	82	27	of	of	ADP
bjp-19568	82	28	withaferin	withaferin	NOUN
bjp-19568	82	29	a	a	PRON
bjp-19568	82	30	on	on	ADP
bjp-19568	82	31	osteosarcoma	osteosarcoma	ADJ
bjp-19568	82	32	cells	cell	NOUN
bjp-19568	82	33	.	.	PUNCT
bjp-19568	83	1	to	to	PART
bjp-19568	83	2	further	far	ADV
bjp-19568	83	3	investigate	investigate	VERB
bjp-19568	83	4	whether	whether	SCONJ
bjp-19568	83	5	withaferin	withaferin	NOUN
bjp-19568	83	6	a	a	PRON
bjp-19568	83	7	was	be	AUX
bjp-19568	83	8	inducing	induce	VERB
bjp-19568	83	9	cell	cell	NOUN
bjp-19568	83	10	cycle	cycle	NOUN
bjp-19568	83	11	arrest	arrest	NOUN
bjp-19568	83	12	of	of	ADP
bjp-19568	83	13	osteosarcoma	osteosarcoma	ADJ
bjp-19568	83	14	cells	cell	NOUN
bjp-19568	83	15	,	,	PUNCT
bjp-19568	83	16	a	a	DET
bjp-19568	83	17	cell	cell	NOUN
bjp-19568	83	18	cycle	cycle	NOUN
bjp-19568	83	19	analysis	analysis	NOUN
bjp-19568	83	20	was	be	AUX
bjp-19568	83	21	conducted	conduct	VERB
bjp-19568	83	22	.	.	PUNCT
bjp-19568	84	1	cell	cell	NOUN
bjp-19568	84	2	cycle	cycle	NOUN
bjp-19568	84	3	distribution	distribution	NOUN
bjp-19568	84	4	of	of	ADP
bjp-19568	84	5	u2os	u2o	NOUN
bjp-19568	84	6	,	,	PUNCT
bjp-19568	84	7	saos-2	saos-2	NUM
bjp-19568	84	8	and	and	CCONJ
bjp-19568	84	9	mg-63	mg-63	NOUN
bjp-19568	84	10	cells	cell	NOUN
bjp-19568	84	11	,	,	PUNCT
bjp-19568	84	12	following	follow	VERB
bjp-19568	84	13	a	a	DET
bjp-19568	84	14	48	48	NUM
bjp-19568	84	15	hours	hour	NOUN
bjp-19568	84	16	treatment	treatment	NOUN
bjp-19568	84	17	with	with	ADP
bjp-19568	84	18	15	15	NUM
bjp-19568	84	19	ml	ml	NOUN
bjp-19568	84	20	of	of	ADP
bjp-19568	84	21	withaferin	withaferin	PROPN
bjp-19568	84	22	a	a	PROPN
bjp-19568	84	23	,	,	PUNCT
bjp-19568	84	24	was	be	AUX
bjp-19568	84	25	determined	determine	VERB
bjp-19568	84	26	by	by	ADP
bjp-19568	84	27	propidium	propidium	NOUN
bjp-19568	84	28	iodide	iodide	NOUN
bjp-19568	84	29	(	(	PUNCT
bjp-19568	84	30	pi	pi	NOUN
bjp-19568	84	31	)	)	PUNCT
bjp-19568	84	32	staining	stain	VERB
bjp-19568	84	33	and	and	CCONJ
bjp-19568	84	34	flow	flow	VERB
bjp-19568	84	35	cytometry	cytometry	NOUN
bjp-19568	84	36	.	.	PUNCT
bjp-19568	85	1	as	as	SCONJ
bjp-19568	85	2	seen	see	VERB
bjp-19568	85	3	in	in	ADP
bjp-19568	85	4	figure	figure	NOUN
bjp-19568	85	5	2	2	NUM
bjp-19568	85	6	,	,	PUNCT
bjp-19568	85	7	treatment	treatment	NOUN
bjp-19568	85	8	with	with	ADP
bjp-19568	85	9	withaferin	withaferin	NOUN
bjp-19568	85	10	a	a	DET
bjp-19568	85	11	resulted	result	VERB
bjp-19568	85	12	in	in	ADP
bjp-19568	85	13	an	an	DET
bjp-19568	85	14	increase	increase	NOUN
bjp-19568	85	15	in	in	ADP
bjp-19568	85	16	the	the	DET
bjp-19568	85	17	number	number	NOUN
bjp-19568	85	18	of	of	ADP
bjp-19568	85	19	cells	cell	NOUN
bjp-19568	85	20	in	in	ADP
bjp-19568	85	21	the	the	DET
bjp-19568	85	22	g2⁄m	g2⁄m	NUM
bjp-19568	85	23	phase	phase	NOUN
bjp-19568	85	24	and	and	CCONJ
bjp-19568	85	25	a	a	DET
bjp-19568	85	26	decrease	decrease	NOUN
bjp-19568	85	27	in	in	ADP
bjp-19568	85	28	the	the	DET
bjp-19568	85	29	number	number	NOUN
bjp-19568	85	30	of	of	ADP
bjp-19568	85	31	cells	cell	NOUN
bjp-19568	85	32	in	in	ADP
bjp-19568	85	33	the	the	DET
bjp-19568	85	34	g0⁄g1	g0⁄g1	ADJ
bjp-19568	85	35	phase	phase	NOUN
bjp-19568	85	36	,	,	PUNCT
bjp-19568	85	37	indicating	indicate	VERB
bjp-19568	85	38	a	a	DET
bjp-19568	85	39	withaferin	withaferin	NOUN
bjp-19568	85	40	a	a	PRON
bjp-19568	85	41	-	-	PUNCT
bjp-19568	85	42	induced	induced	ADJ
bjp-19568	85	43	g2⁄m	g2⁄m	NUM
bjp-19568	85	44	phase	phase	NOUN
bjp-19568	85	45	arrest	arrest	NOUN
bjp-19568	85	46	.	.	PUNCT
bjp-19568	86	1	these	these	DET
bjp-19568	86	2	data	datum	NOUN
bjp-19568	86	3	suggested	suggest	VERB
bjp-19568	86	4	that	that	SCONJ
bjp-19568	86	5	the	the	DET
bjp-19568	86	6	decreased	decrease	VERB
bjp-19568	86	7	proliferation	proliferation	NOUN
bjp-19568	86	8	in	in	ADP
bjp-19568	86	9	withaferin	withaferin	PROPN
bjp-19568	86	10	a	a	ADV
bjp-19568	86	11	-	-	PUNCT
bjp-19568	86	12	treated	treat	VERB
bjp-19568	86	13	osteosarcoma	osteosarcoma	ADJ
bjp-19568	86	14	cells	cell	NOUN
bjp-19568	86	15	is	be	AUX
bjp-19568	86	16	at	at	ADP
bjp-19568	86	17	least	least	ADJ
bjp-19568	86	18	partially	partially	ADV
bjp-19568	86	19	a	a	DET
bjp-19568	86	20	result	result	NOUN
bjp-19568	86	21	of	of	ADP
bjp-19568	86	22	the	the	DET
bjp-19568	86	23	cell	cell	NOUN
bjp-19568	86	24	cycle	cycle	NOUN
bjp-19568	86	25	arrest	arrest	NOUN
bjp-19568	86	26	by	by	ADP
bjp-19568	86	27	withaferin	withaferin	PROPN
bjp-19568	86	28	a.	a.	NOUN
bjp-19568	86	29	to	to	PART
bjp-19568	86	30	understand	understand	VERB
bjp-19568	86	31	further	far	ADV
bjp-19568	86	32	the	the	DET
bjp-19568	86	33	molecular	molecular	ADJ
bjp-19568	86	34	mechanism	mechanism	NOUN
bjp-19568	86	35	involved	involve	VERB
bjp-19568	86	36	in	in	ADP
bjp-19568	86	37	withaferin	withaferin	PROPN
bjp-19568	86	38	a	a	PRON
bjp-19568	86	39	-	-	PUNCT
bjp-19568	86	40	induced	induce	VERB
bjp-19568	86	41	proliferation	proliferation	NOUN
bjp-19568	86	42	inhibition	inhibition	NOUN
bjp-19568	86	43	,	,	PUNCT
bjp-19568	86	44	alterations	alteration	NOUN
bjp-19568	86	45	in	in	ADP
bjp-19568	86	46	the	the	DET
bjp-19568	86	47	cell	cell	NOUN
bjp-19568	86	48	survival	survival	NOUN
bjp-19568	86	49	notch	notch	NOUN
bjp-19568	86	50	pathway	pathway	NOUN
bjp-19568	86	51	were	be	AUX
bjp-19568	86	52	investigated	investigate	VERB
bjp-19568	86	53	.	.	PUNCT
bjp-19568	87	1	notch-1	notch-1	NUM
bjp-19568	87	2	and	and	CCONJ
bjp-19568	87	3	its	its	PRON
bjp-19568	87	4	target	target	NOUN
bjp-19568	87	5	genes	gene	NOUN
bjp-19568	87	6	hes-1	hes-1	NOUN
bjp-19568	87	7	,	,	PUNCT
bjp-19568	87	8	hey-1	hey-1	NOUN
bjp-19568	87	9	,	,	PUNCT
bjp-19568	87	10	hey-2	hey-2	VERB
bjp-19568	87	11	expression	expression	NOUN
bjp-19568	87	12	in	in	ADP
bjp-19568	87	13	u2os	u2os	PUNCT
bjp-19568	87	14	and	and	CCONJ
bjp-19568	87	15	mg-63	mg-63	NOUN
bjp-19568	87	16	cells	cell	NOUN
bjp-19568	87	17	treated	treat	VERB
bjp-19568	87	18	with	with	ADP
bjp-19568	87	19	increasing	increase	VERB
bjp-19568	87	20	concentrations	concentration	NOUN
bjp-19568	87	21	of	of	ADP
bjp-19568	87	22	withaferin	withaferin	NOUN
bjp-19568	87	23	a	a	PRON
bjp-19568	87	24	for	for	ADP
bjp-19568	87	25	48	48	NUM
bjp-19568	87	26	hours	hour	NOUN
bjp-19568	87	27	were	be	AUX
bjp-19568	87	28	assessed	assess	VERB
bjp-19568	87	29	using	use	VERB
bjp-19568	87	30	real	real	ADJ
bjp-19568	87	31	-	-	PUNCT
bjp-19568	87	32	time	time	NOUN
bjp-19568	87	33	rt	rt	ADJ
bjp-19568	87	34	-	-	PUNCT
bjp-19568	87	35	pcr	pcr	NOUN
bjp-19568	87	36	analysis	analysis	NOUN
bjp-19568	87	37	.	.	PUNCT
bjp-19568	88	1	compared	compare	VERB
bjp-19568	88	2	with	with	ADP
bjp-19568	88	3	control	control	NOUN
bjp-19568	88	4	,	,	PUNCT
bjp-19568	88	5	there	there	PRON
bjp-19568	88	6	was	be	VERB
bjp-19568	88	7	a	a	DET
bjp-19568	88	8	reduction	reduction	NOUN
bjp-19568	88	9	of	of	ADP
bjp-19568	88	10	notch-1	notch-1	PROPN
bjp-19568	88	11	,	,	PUNCT
bjp-19568	88	12	hes-1	hes-1	NOUN
bjp-19568	88	13	,	,	PUNCT
bjp-19568	88	14	hey-1	hey-1	NOUN
bjp-19568	88	15	and	and	CCONJ
bjp-19568	88	16	hey-2	hey-2	ADP
bjp-19568	88	17	mrna	mrna	PROPN
bjp-19568	88	18	levels	level	NOUN
bjp-19568	88	19	after	after	ADP
bjp-19568	88	20	withaferin	withaferin	NOUN
bjp-19568	88	21	a	a	DET
bjp-19568	88	22	treatment	treatment	NOUN
bjp-19568	88	23	,	,	PUNCT
bjp-19568	88	24	suggesting	suggest	VERB
bjp-19568	88	25	that	that	DET
bjp-19568	88	26	withaferin	withaferin	NOUN
bjp-19568	88	27	a	a	DET
bjp-19568	88	28	resulted	result	VERB
bjp-19568	88	29	in	in	ADP
bjp-19568	88	30	the	the	DET
bjp-19568	88	31	transcriptional	transcriptional	ADJ
bjp-19568	88	32	inactivation	inactivation	NOUN
bjp-19568	88	33	of	of	ADP
bjp-19568	88	34	notch-1	notch-1	NUM
bjp-19568	88	35	signaling	signal	VERB
bjp-19568	88	36	pathway	pathway	NOUN
bjp-19568	88	37	in	in	ADP
bjp-19568	88	38	osteosarcoma	osteosarcoma	ADJ
bjp-19568	88	39	cells	cell	NOUN
bjp-19568	88	40	(	(	PUNCT
bjp-19568	88	41	figure	figure	NOUN
bjp-19568	88	42	3a	3a	NUM
bjp-19568	88	43	)	)	PUNCT
bjp-19568	88	44	.	.	PUNCT
bjp-19568	89	1	it	it	PRON
bjp-19568	89	2	is	be	AUX
bjp-19568	89	3	important	important	ADJ
bjp-19568	89	4	to	to	PART
bjp-19568	89	5	note	note	VERB
bjp-19568	89	6	that	that	SCONJ
bjp-19568	89	7	the	the	DET
bjp-19568	89	8	active	active	ADJ
bjp-19568	89	9	functional	functional	ADJ
bjp-19568	89	10	form	form	NOUN
bjp-19568	89	11	of	of	ADP
bjp-19568	89	12	notch	notch	NOUN
bjp-19568	89	13	is	be	AUX
bjp-19568	89	14	notch-1	notch-1	NUM
bjp-19568	89	15	intracellular	intracellular	ADJ
bjp-19568	89	16	domain	domain	NOUN
bjp-19568	89	17	.	.	PUNCT
bjp-19568	90	1	therefore	therefore	ADV
bjp-19568	90	2	,	,	PUNCT
bjp-19568	90	3	we	we	PRON
bjp-19568	90	4	focused	focus	VERB
bjp-19568	90	5	our	our	PRON
bjp-19568	90	6	studies	study	NOUN
bjp-19568	90	7	on	on	ADP
bjp-19568	90	8	notch-1	notch-1	NUM
bjp-19568	90	9	intracellular	intracellular	ADJ
bjp-19568	90	10	domain	domain	NOUN
bjp-19568	90	11	at	at	ADP
bjp-19568	90	12	the	the	DET
bjp-19568	90	13	protein	protein	NOUN
bjp-19568	90	14	level	level	NOUN
bjp-19568	90	15	and	and	CCONJ
bjp-19568	90	16	notch-1	notch-1	NUM
bjp-19568	90	17	in	in	ADP
bjp-19568	90	18	all	all	DET
bjp-19568	90	19	figure	figure	NOUN
bjp-19568	90	20	legends	legend	NOUN
bjp-19568	90	21	means	mean	VERB
bjp-19568	90	22	the	the	DET
bjp-19568	90	23	active	active	ADJ
bjp-19568	90	24	functional	functional	ADJ
bjp-19568	90	25	form	form	NOUN
bjp-19568	90	26	of	of	ADP
bjp-19568	90	27	notch-1	notch-1	PROPN
bjp-19568	90	28	.	.	PUNCT
bjp-19568	91	1	in	in	ADP
bjp-19568	91	2	agreement	agreement	NOUN
bjp-19568	91	3	with	with	ADP
bjp-19568	91	4	the	the	DET
bjp-19568	91	5	real	real	ADJ
bjp-19568	91	6	-	-	PUNCT
bjp-19568	91	7	time	time	NOUN
bjp-19568	91	8	rt	rt	ADJ
bjp-19568	91	9	-	-	PUNCT
bjp-19568	91	10	pcr	pcr	ADJ
bjp-19568	91	11	data	datum	NOUN
bjp-19568	91	12	,	,	PUNCT
bjp-19568	91	13	western	western	ADJ
bjp-19568	91	14	blot	blot	NOUN
bjp-19568	91	15	showed	show	VERB
bjp-19568	91	16	that	that	SCONJ
bjp-19568	91	17	notch-1	notch-1	NUM
bjp-19568	91	18	protein	protein	NOUN
bjp-19568	91	19	levels	level	NOUN
bjp-19568	91	20	were	be	AUX
bjp-19568	91	21	down	down	ADV
bjp-19568	91	22	-	-	PUNCT
bjp-19568	91	23	regulated	regulate	VERB
bjp-19568	91	24	in	in	ADP
bjp-19568	91	25	both	both	PRON
bjp-19568	91	26	u2os	u2os	PUNCT
bjp-19568	91	27	and	and	CCONJ
bjp-19568	91	28	mg-63	mg-63	NOUN
bjp-19568	91	29	cells	cell	NOUN
bjp-19568	91	30	treated	treat	VERB
bjp-19568	91	31	with	with	ADP
bjp-19568	91	32	withaferin	withaferin	NOUN
bjp-19568	91	33	a	a	PRON
bjp-19568	91	34	in	in	ADP
bjp-19568	91	35	a	a	DET
bjp-19568	91	36	dose	dose	NOUN
bjp-19568	91	37	-	-	PUNCT
bjp-19568	91	38	dependent	dependent	ADJ
bjp-19568	91	39	manner	manner	NOUN
bjp-19568	91	40	(	(	PUNCT
bjp-19568	91	41	figure	figure	NOUN
bjp-19568	91	42	3b	3b	NUM
bjp-19568	91	43	)	)	PUNCT
bjp-19568	91	44	.	.	PUNCT
bjp-19568	92	1	together	together	ADV
bjp-19568	92	2	,	,	PUNCT
bjp-19568	92	3	we	we	PRON
bjp-19568	92	4	concluded	conclude	VERB
bjp-19568	92	5	that	that	DET
bjp-19568	92	6	withaferin	withaferin	NOUN
bjp-19568	92	7	a	a	DET
bjp-19568	92	8	regulated	regulated	ADJ
bjp-19568	92	9	the	the	DET
bjp-19568	92	10	transcription	transcription	NOUN
bjp-19568	92	11	and	and	CCONJ
bjp-19568	92	12	translation	translation	NOUN
bjp-19568	92	13	of	of	ADP
bjp-19568	92	14	the	the	DET
bjp-19568	92	15	notch-1	notch-1	NUM
bjp-19568	92	16	gene	gene	NOUN
bjp-19568	92	17	.	.	PUNCT
bjp-19568	93	1	to	to	PART
bjp-19568	93	2	confirm	confirm	VERB
bjp-19568	93	3	the	the	DET
bjp-19568	93	4	inactivation	inactivation	NOUN
bjp-19568	93	5	of	of	ADP
bjp-19568	93	6	notch-1	notch-1	NUM
bjp-19568	93	7	signaling	signal	VERB
bjp-19568	93	8	by	by	ADP
bjp-19568	93	9	witha	witha	NOUN
bjp-19568	93	10	-	-	PUNCT
bjp-19568	93	11	ferin	ferin	PROPN
bjp-19568	93	12	a	a	X
bjp-19568	93	13	,	,	PUNCT
bjp-19568	93	14	we	we	PRON
bjp-19568	93	15	also	also	ADV
bjp-19568	93	16	detected	detect	VERB
bjp-19568	93	17	the	the	DET
bjp-19568	93	18	other	other	ADJ
bjp-19568	93	19	notch	notch	ADJ
bjp-19568	93	20	downstream	downstream	ADJ
bjp-19568	93	21	target	target	NOUN
bjp-19568	93	22	genes	gene	NOUN
bjp-19568	93	23	bangladesh	bangladesh	PROPN
bjp-19568	93	24	j	j	PROPN
bjp-19568	93	25	pharmacol	pharmacol	PROPN
bjp-19568	93	26	2014	2014	NUM
bjp-19568	93	27	;	;	PUNCT
bjp-19568	93	28	9	9	NUM
bjp-19568	93	29	:	:	SYM
bjp-19568	93	30	364	364	NUM
bjp-19568	93	31	-	-	SYM
bjp-19568	93	32	370	370	NUM
bjp-19568	93	33	367	367	NUM
bjp-19568	93	34	figure	figure	NOUN
bjp-19568	93	35	2	2	NUM
bjp-19568	93	36	:	:	PUNCT
bjp-19568	93	37	withaferin	withaferin	NOUN
bjp-19568	93	38	a	a	ADV
bjp-19568	93	39	-	-	PUNCT
bjp-19568	93	40	induced	induce	VERB
bjp-19568	93	41	g2	g2	PROPN
bjp-19568	93	42	⁄m	⁄m	NOUN
bjp-19568	93	43	phase	phase	NOUN
bjp-19568	93	44	arrest	arrest	NOUN
bjp-19568	93	45	in	in	ADP
bjp-19568	93	46	osteosarcoma	osteosarcoma	ADJ
bjp-19568	93	47	cells	cell	NOUN
bjp-19568	93	48	was	be	AUX
bjp-19568	93	49	measured	measure	VERB
bjp-19568	93	50	with	with	ADP
bjp-19568	93	51	cell	cell	NOUN
bjp-19568	93	52	cycle	cycle	NOUN
bjp-19568	93	53	distribution	distribution	NOUN
bjp-19568	93	54	by	by	ADP
bjp-19568	93	55	flow	flow	NOUN
bjp-19568	93	56	cytometry	cytometry	NOUN
bjp-19568	93	57	analysis	analysis	NOUN
bjp-19568	93	58	c	c	NOUN
bjp-19568	93	59	,	,	PUNCT
bjp-19568	93	60	control	control	NOUN
bjp-19568	93	61	;	;	PUNCT
bjp-19568	93	62	10	10	NUM
bjp-19568	93	63	,	,	PUNCT
bjp-19568	93	64	20	20	NUM
bjp-19568	93	65	µm	µm	NOUN
bjp-19568	93	66	withaferin	withaferin	PROPN
bjp-19568	93	67	a.	a.	PROPN
bjp-19568	93	68	u2os	u2os	PROPN
bjp-19568	93	69	,	,	PUNCT
bjp-19568	93	70	saos-2	saos-2	NUM
bjp-19568	93	71	and	and	CCONJ
bjp-19568	93	72	mg-63	mg-63	NOUN
bjp-19568	93	73	cells	cell	NOUN
bjp-19568	93	74	were	be	AUX
bjp-19568	93	75	treated	treat	VERB
bjp-19568	93	76	with	with	ADP
bjp-19568	93	77	10	10	NUM
bjp-19568	93	78	and	and	CCONJ
bjp-19568	93	79	20	20	NUM
bjp-19568	93	80	µm	µm	NOUN
bjp-19568	93	81	withaferin	withaferin	NOUN
bjp-19568	93	82	a	a	PRON
bjp-19568	93	83	for	for	ADP
bjp-19568	93	84	48	48	NUM
bjp-19568	93	85	hours	hour	NOUN
bjp-19568	93	86	(	(	PUNCT
bjp-19568	93	87	control	control	NOUN
bjp-19568	93	88	:	:	PUNCT
bjp-19568	93	89	cells	cell	NOUN
bjp-19568	93	90	treated	treat	VERB
bjp-19568	93	91	withdimethylsulfoxide	withdimethylsulfoxide	NOUN
bjp-19568	93	92	)	)	PUNCT
bjp-19568	93	93	.	.	PUNCT
bjp-19568	94	1	treatment	treatment	NOUN
bjp-19568	94	2	with	with	ADP
bjp-19568	94	3	withaferin	withaferin	PROPN
bjp-19568	94	4	a	a	DET
bjp-19568	94	5	resulted	result	VERB
bjp-19568	94	6	in	in	ADP
bjp-19568	94	7	an	an	DET
bjp-19568	94	8	increase	increase	NOUN
bjp-19568	94	9	in	in	ADP
bjp-19568	94	10	the	the	DET
bjp-19568	94	11	number	number	NOUN
bjp-19568	94	12	of	of	ADP
bjp-19568	94	13	cells	cell	NOUN
bjp-19568	94	14	in	in	ADP
bjp-19568	94	15	the	the	DET
bjp-19568	94	16	g2	g2	PROPN
bjp-19568	94	17	⁄m	⁄m	NOUN
bjp-19568	94	18	phase	phase	NOUN
bjp-19568	94	19	and	and	CCONJ
bjp-19568	94	20	a	a	DET
bjp-19568	94	21	decrease	decrease	NOUN
bjp-19568	94	22	in	in	ADP
bjp-19568	94	23	the	the	DET
bjp-19568	94	24	number	number	NOUN
bjp-19568	94	25	of	of	ADP
bjp-19568	94	26	cells	cell	NOUN
bjp-19568	94	27	in	in	ADP
bjp-19568	94	28	the	the	DET
bjp-19568	94	29	g0⁄g1	g0⁄g1	ADJ
bjp-19568	94	30	phase	phase	NOUN
bjp-19568	94	31	,	,	PUNCT
bjp-19568	94	32	indicating	indicate	VERB
bjp-19568	94	33	a	a	DET
bjp-19568	94	34	withaferin	withaferin	NOUN
bjp-19568	94	35	a	a	PRON
bjp-19568	94	36	-	-	PUNCT
bjp-19568	94	37	induced	induced	ADJ
bjp-19568	94	38	g2⁄m	g2⁄m	NUM
bjp-19568	94	39	phase	phase	NOUN
bjp-19568	94	40	arrest	arrest	NOUN
bjp-19568	94	41	.	.	PUNCT
bjp-19568	95	1	results	result	NOUN
bjp-19568	95	2	are	be	AUX
bjp-19568	95	3	plotted	plot	VERB
bjp-19568	95	4	as	as	ADP
bjp-19568	95	5	the	the	DET
bjp-19568	95	6	percentage	percentage	NOUN
bjp-19568	95	7	of	of	ADP
bjp-19568	95	8	cells	cell	NOUN
bjp-19568	95	9	in	in	ADP
bjp-19568	95	10	each	each	DET
bjp-19568	95	11	cell	cell	NOUN
bjp-19568	95	12	cycle	cycle	NOUN
bjp-19568	95	13	phase	phase	NOUN
bjp-19568	95	14	.	.	PUNCT
bjp-19568	96	1	data	datum	NOUN
bjp-19568	96	2	are	be	AUX
bjp-19568	96	3	presented	present	VERB
bjp-19568	96	4	as	as	ADP
bjp-19568	96	5	mean	mean	NOUN
bjp-19568	96	6	±	±	NUM
bjp-19568	96	7	sd	sd	NOUN
bjp-19568	96	8	of	of	ADP
bjp-19568	96	9	three	three	NUM
bjp-19568	96	10	independent	independent	ADJ
bjp-19568	96	11	experiments	experiment	NOUN
bjp-19568	96	12	such	such	ADJ
bjp-19568	96	13	as	as	ADP
bjp-19568	96	14	hes-1	hes-1	PUNCT
bjp-19568	96	15	and	and	CCONJ
bjp-19568	96	16	cyclin	cyclin	NOUN
bjp-19568	96	17	d1	d1	PROPN
bjp-19568	96	18	.	.	PUNCT
bjp-19568	97	1	the	the	DET
bjp-19568	97	2	results	result	NOUN
bjp-19568	97	3	demonstrated	demonstrate	VERB
bjp-19568	97	4	that	that	SCONJ
bjp-19568	97	5	the	the	DET
bjp-19568	97	6	expression	expression	NOUN
bjp-19568	97	7	of	of	ADP
bjp-19568	97	8	hes-1	hes-1	X
bjp-19568	97	9	and	and	CCONJ
bjp-19568	97	10	cyclin	cyclin	NOUN
bjp-19568	97	11	d1	d1	PROPN
bjp-19568	97	12	was	be	AUX
bjp-19568	97	13	also	also	ADV
bjp-19568	97	14	inhibited	inhibit	VERB
bjp-19568	97	15	by	by	ADP
bjp-19568	97	16	treatment	treatment	NOUN
bjp-19568	97	17	with	with	ADP
bjp-19568	97	18	withaferin	withaferin	PROPN
bjp-19568	97	19	a	a	DET
bjp-19568	97	20	(	(	PUNCT
bjp-19568	97	21	figure	figure	NOUN
bjp-19568	97	22	3b	3b	NUM
bjp-19568	97	23	)	)	PUNCT
bjp-19568	97	24	.	.	PUNCT
bjp-19568	98	1	to	to	PART
bjp-19568	98	2	explore	explore	VERB
bjp-19568	98	3	whether	whether	SCONJ
bjp-19568	98	4	the	the	DET
bjp-19568	98	5	downstream	downstream	ADJ
bjp-19568	98	6	effect	effect	NOUN
bjp-19568	98	7	of	of	ADP
bjp-19568	98	8	withaferin	withaferin	NOUN
bjp-19568	98	9	a	a	DET
bjp-19568	98	10	induced	induce	VERB
bjp-19568	98	11	by	by	ADP
bjp-19568	98	12	down	down	ADP
bjp-19568	98	13	-	-	PUNCT
bjp-19568	98	14	regulation	regulation	NOUN
bjp-19568	98	15	of	of	ADP
bjp-19568	98	16	notch-1	notch-1	NUM
bjp-19568	98	17	was	be	AUX
bjp-19568	98	18	associated	associate	VERB
bjp-19568	98	19	mechanistically	mechanistically	ADV
bjp-19568	98	20	with	with	ADP
bjp-19568	98	21	mmp	mmp	PROPN
bjp-19568	98	22	induction	induction	NOUN
bjp-19568	98	23	,	,	PUNCT
bjp-19568	98	24	we	we	PRON
bjp-19568	98	25	conducted	conduct	VERB
bjp-19568	98	26	real	real	ADJ
bjp-19568	98	27	-	-	PUNCT
bjp-19568	98	28	time	time	NOUN
bjp-19568	98	29	rt	rt	NOUN
bjp-19568	98	30	-	-	PUNCT
bjp-19568	98	31	pcr	pcr	ADJ
bjp-19568	98	32	and	and	CCONJ
bjp-19568	98	33	western	western	ADJ
bjp-19568	98	34	blot	blot	NOUN
bjp-19568	98	35	analysis	analysis	NOUN
bjp-19568	98	36	to	to	PART
bjp-19568	98	37	detect	detect	VERB
bjp-19568	98	38	the	the	DET
bjp-19568	98	39	alterations	alteration	NOUN
bjp-19568	98	40	in	in	ADP
bjp-19568	98	41	the	the	DET
bjp-19568	98	42	expression	expression	NOUN
bjp-19568	98	43	of	of	ADP
bjp-19568	98	44	mmp-2	mmp-2	NUM
bjp-19568	98	45	and	and	CCONJ
bjp-19568	98	46	mmp-9	mmp-9	NOUN
bjp-19568	98	47	.	.	PUNCT
bjp-19568	99	1	the	the	DET
bjp-19568	99	2	results	result	NOUN
bjp-19568	99	3	showed	show	VERB
bjp-19568	99	4	that	that	SCONJ
bjp-19568	99	5	,	,	PUNCT
bjp-19568	99	6	compared	compare	VERB
bjp-19568	99	7	with	with	ADP
bjp-19568	99	8	control	control	NOUN
bjp-19568	99	9	cells	cell	NOUN
bjp-19568	99	10	,	,	PUNCT
bjp-19568	99	11	both	both	CCONJ
bjp-19568	99	12	mmp2	mmp2	ADJ
bjp-19568	99	13	and	and	CCONJ
bjp-19568	99	14	mmp-9	mmp-9	NOUN
bjp-19568	99	15	mrna	mrna	NOUN
bjp-19568	99	16	and	and	CCONJ
bjp-19568	99	17	protein	protein	NOUN
bjp-19568	99	18	levels	level	NOUN
bjp-19568	99	19	were	be	AUX
bjp-19568	99	20	dramatically	dramatically	ADV
bjp-19568	99	21	down	down	ADV
bjp-19568	99	22	-	-	PUNCT
bjp-19568	99	23	regulated	regulate	VERB
bjp-19568	99	24	in	in	ADP
bjp-19568	99	25	withaferin	withaferin	NOUN
bjp-19568	99	26	a	a	ADV
bjp-19568	99	27	-	-	PUNCT
bjp-19568	99	28	treated	treat	VERB
bjp-19568	99	29	u2os	u2os	PUNCT
bjp-19568	99	30	and	and	CCONJ
bjp-19568	99	31	mg-63	mg-63	NOUN
bjp-19568	99	32	cells	cell	NOUN
bjp-19568	99	33	,	,	PUNCT
bjp-19568	99	34	respectively	respectively	ADV
bjp-19568	99	35	.	.	PUNCT
bjp-19568	100	1	withaferin	withaferin	PROPN
bjp-19568	100	2	a	a	DET
bjp-19568	100	3	decreased	decrease	VERB
bjp-19568	100	4	mmp-2	mmp-2	ADV
bjp-19568	100	5	and	and	CCONJ
bjp-19568	100	6	mmp-9	mmp-9	NOUN
bjp-19568	100	7	expression	expression	NOUN
bjp-19568	100	8	in	in	ADP
bjp-19568	100	9	a	a	DET
bjp-19568	100	10	dose	dose	NOUN
bjp-19568	100	11	-	-	PUNCT
bjp-19568	100	12	dependent	dependent	ADJ
bjp-19568	100	13	manner	manner	NOUN
bjp-19568	100	14	(	(	PUNCT
bjp-19568	100	15	figure	figure	NOUN
bjp-19568	100	16	4a	4a	NOUN
bjp-19568	100	17	,	,	PUNCT
bjp-19568	100	18	b	b	NOUN
bjp-19568	100	19	)	)	PUNCT
bjp-19568	100	20	.	.	PUNCT
bjp-19568	101	1	these	these	DET
bjp-19568	101	2	data	datum	NOUN
bjp-19568	101	3	indicated	indicate	VERB
bjp-19568	101	4	that	that	SCONJ
bjp-19568	101	5	withaferin	withaferin	NOUN
bjp-19568	101	6	a	a	DET
bjp-19568	101	7	inhibited	inhibited	ADJ
bjp-19568	101	8	the	the	DET
bjp-19568	101	9	expression	expression	NOUN
bjp-19568	101	10	and	and	CCONJ
bjp-19568	101	11	activities	activity	NOUN
bjp-19568	101	12	of	of	ADP
bjp-19568	101	13	mmp-2	mmp-2	NUM
bjp-19568	101	14	and	and	CCONJ
bjp-19568	101	15	mmp-9	mmp-9	NOUN
bjp-19568	101	16	in	in	ADP
bjp-19568	101	17	osteosarcoma	osteosarcoma	ADJ
bjp-19568	101	18	cells	cell	NOUN
bjp-19568	101	19	.	.	PUNCT
bjp-19568	102	1	discussion	discussion	NOUN
bjp-19568	102	2	in	in	ADP
bjp-19568	102	3	the	the	DET
bjp-19568	102	4	present	present	ADJ
bjp-19568	102	5	study	study	NOUN
bjp-19568	102	6	,	,	PUNCT
bjp-19568	102	7	we	we	PRON
bjp-19568	102	8	showed	show	VERB
bjp-19568	102	9	that	that	DET
bjp-19568	102	10	withaferin	withaferin	NOUN
bjp-19568	102	11	a	a	DET
bjp-19568	102	12	elicited	elicited	ADJ
bjp-19568	102	13	a	a	DET
bjp-19568	102	14	dramatic	dramatic	ADJ
bjp-19568	102	15	effect	effect	NOUN
bjp-19568	102	16	on	on	ADP
bjp-19568	102	17	proliferation	proliferation	NOUN
bjp-19568	102	18	inhibition	inhibition	NOUN
bjp-19568	102	19	and	and	CCONJ
bjp-19568	102	20	g2⁄m	g2⁄m	NUM
bjp-19568	102	21	cell	cell	NOUN
bjp-19568	102	22	cycle	cycle	NOUN
bjp-19568	102	23	arrest	arrest	NOUN
bjp-19568	102	24	in	in	ADP
bjp-19568	102	25	u2os	u2o	NOUN
bjp-19568	102	26	,	,	PUNCT
bjp-19568	102	27	saos-2	saos-2	NUM
bjp-19568	102	28	and	and	CCONJ
bjp-19568	102	29	mg-63	mg-63	NOUN
bjp-19568	102	30	osteosarcoma	osteosarcoma	ADJ
bjp-19568	102	31	cells	cell	NOUN
bjp-19568	102	32	,	,	PUNCT
bjp-19568	102	33	as	as	SCONJ
bjp-19568	102	34	demonstrated	demonstrate	VERB
bjp-19568	102	35	by	by	ADP
bjp-19568	102	36	the	the	DET
bjp-19568	102	37	mtt	mtt	NOUN
bjp-19568	102	38	assay	assay	VERB
bjp-19568	102	39	and	and	CCONJ
bjp-19568	102	40	flow	flow	VERB
bjp-19568	102	41	cytometry	cytometry	ADJ
bjp-19568	102	42	analysis	analysis	NOUN
bjp-19568	102	43	,	,	PUNCT
bjp-19568	102	44	respectively	respectively	ADV
bjp-19568	102	45	.	.	PUNCT
bjp-19568	103	1	these	these	DET
bjp-19568	103	2	results	result	NOUN
bjp-19568	103	3	are	be	AUX
bjp-19568	103	4	consistent	consistent	ADJ
bjp-19568	103	5	with	with	ADP
bjp-19568	103	6	the	the	DET
bjp-19568	103	7	data	datum	NOUN
bjp-19568	103	8	published	publish	VERB
bjp-19568	103	9	by	by	ADP
bjp-19568	103	10	other	other	ADJ
bjp-19568	103	11	groups	group	NOUN
bjp-19568	103	12	(	(	PUNCT
bjp-19568	103	13	koduru	koduru	NOUN
bjp-19568	103	14	et	et	PROPN
bjp-19568	103	15	al	al	PROPN
bjp-19568	103	16	.	.	PROPN
bjp-19568	103	17	,	,	PUNCT
bjp-19568	103	18	2010	2010	NUM
bjp-19568	103	19	)	)	PUNCT
bjp-19568	103	20	.	.	PUNCT
bjp-19568	104	1	to	to	PART
bjp-19568	104	2	elucidate	elucidate	VERB
bjp-19568	104	3	the	the	DET
bjp-19568	104	4	molecular	molecular	ADJ
bjp-19568	104	5	mechanisms	mechanism	NOUN
bjp-19568	104	6	of	of	ADP
bjp-19568	104	7	growth	growth	NOUN
bjp-19568	104	8	and	and	CCONJ
bjp-19568	104	9	invasion	invasion	NOUN
bjp-19568	104	10	inhibition	inhibition	NOUN
bjp-19568	104	11	by	by	ADP
bjp-19568	104	12	withaferin	withaferin	PROPN
bjp-19568	104	13	a	a	NOUN
bjp-19568	104	14	,	,	PUNCT
bjp-19568	104	15	we	we	PRON
bjp-19568	104	16	investigated	investigate	VERB
bjp-19568	104	17	the	the	DET
bjp-19568	104	18	activity	activity	NOUN
bjp-19568	104	19	of	of	ADP
bjp-19568	104	20	notch-1	notch-1	PROPN
bjp-19568	104	21	,	,	PUNCT
bjp-19568	104	22	which	which	PRON
bjp-19568	104	23	plays	play	VERB
bjp-19568	104	24	a	a	DET
bjp-19568	104	25	key	key	ADJ
bjp-19568	104	26	role	role	NOUN
bjp-19568	104	27	in	in	ADP
bjp-19568	104	28	the	the	DET
bjp-19568	104	29	process	process	NOUN
bjp-19568	104	30	of	of	ADP
bjp-19568	104	31	cell	cell	NOUN
bjp-19568	104	32	survival	survival	NOUN
bjp-19568	104	33	,	,	PUNCT
bjp-19568	104	34	invasion	invasion	NOUN
bjp-19568	104	35	and	and	CCONJ
bjp-19568	104	36	metastasis	metastasis	NOUN
bjp-19568	104	37	(	(	PUNCT
bjp-19568	104	38	zhang	zhang	X
bjp-19568	104	39	et	et	PROPN
bjp-19568	104	40	al	al	PROPN
bjp-19568	104	41	.	.	PROPN
bjp-19568	104	42	,	,	PUNCT
bjp-19568	104	43	2008	2008	NUM
bjp-19568	104	44	;	;	PUNCT
bjp-19568	104	45	wang	wang	PROPN
bjp-19568	104	46	et	et	PROPN
bjp-19568	104	47	al	al	PROPN
bjp-19568	104	48	.	.	PROPN
bjp-19568	104	49	,	,	PUNCT
bjp-19568	104	50	2008	2008	NUM
bjp-19568	104	51	;	;	PUNCT
bjp-19568	104	52	hughes	hughe	NOUN
bjp-19568	104	53	,	,	PUNCT
bjp-19568	104	54	2009	2009	NUM
bjp-19568	104	55	)	)	PUNCT
bjp-19568	104	56	.	.	PUNCT
bjp-19568	105	1	aberrant	aberrant	ADJ
bjp-19568	105	2	activation	activation	NOUN
bjp-19568	105	3	of	of	ADP
bjp-19568	105	4	the	the	DET
bjp-19568	105	5	notch-1	notch-1	NUM
bjp-19568	105	6	signaling	signal	VERB
bjp-19568	105	7	pathway	pathway	NOUN
bjp-19568	105	8	promotes	promote	VERB
bjp-19568	105	9	a	a	DET
bjp-19568	105	10	myriad	myriad	NOUN
bjp-19568	105	11	of	of	ADP
bjp-19568	105	12	cellular	cellular	ADJ
bjp-19568	105	13	activities	activity	NOUN
bjp-19568	105	14	such	such	ADJ
bjp-19568	105	15	as	as	ADP
bjp-19568	105	16	cell	cell	NOUN
bjp-19568	105	17	survival	survival	NOUN
bjp-19568	105	18	,	,	PUNCT
bjp-19568	105	19	proliferation	proliferation	NOUN
bjp-19568	105	20	,	,	PUNCT
bjp-19568	105	21	migration	migration	NOUN
bjp-19568	105	22	and	and	CCONJ
bjp-19568	105	23	invasion	invasion	NOUN
bjp-19568	105	24	,	,	PUNCT
bjp-19568	105	25	and	and	CCONJ
bjp-19568	105	26	suppresses	suppress	VERB
bjp-19568	105	27	apoptosis	apoptosis	NOUN
bjp-19568	105	28	through	through	ADP
bjp-19568	105	29	a	a	DET
bjp-19568	105	30	growth	growth	NOUN
bjp-19568	105	31	-	-	PUNCT
bjp-19568	105	32	factor	factor	NOUN
bjp-19568	105	33	mediated	mediate	VERB
bjp-19568	105	34	survival	survival	NOUN
bjp-19568	105	35	pathway	pathway	NOUN
bjp-19568	105	36	in	in	ADP
bjp-19568	105	37	many	many	ADJ
bjp-19568	105	38	368	368	NUM
bjp-19568	105	39	bangladesh	bangladesh	NOUN
bjp-19568	105	40	j	j	PROPN
bjp-19568	105	41	pharmacol	pharmacol	PROPN
bjp-19568	105	42	2014	2014	NUM
bjp-19568	105	43	;	;	PUNCT
bjp-19568	105	44	9	9	NUM
bjp-19568	105	45	:	:	SYM
bjp-19568	105	46	364	364	NUM
bjp-19568	105	47	-	-	SYM
bjp-19568	105	48	370	370	NUM
bjp-19568	105	49	figure	figure	NOUN
bjp-19568	105	50	3	3	NUM
bjp-19568	105	51	:	:	PUNCT
bjp-19568	105	52	down	down	ADJ
bjp-19568	105	53	-	-	PUNCT
bjp-19568	105	54	regulation	regulation	NOUN
bjp-19568	105	55	of	of	ADP
bjp-19568	105	56	notch-1	notch-1	NUM
bjp-19568	105	57	expression	expression	NOUN
bjp-19568	105	58	by	by	ADP
bjp-19568	105	59	withaferin	withaferin	NOUN
bjp-19568	105	60	a	a	DET
bjp-19568	105	61	treatment	treatment	NOUN
bjp-19568	105	62	u2os	u2os	PUNCT
bjp-19568	105	63	and	and	CCONJ
bjp-19568	105	64	mg-63	mg-63	NOUN
bjp-19568	105	65	cells	cell	NOUN
bjp-19568	105	66	were	be	AUX
bjp-19568	105	67	treated	treat	VERB
bjp-19568	105	68	with	with	ADP
bjp-19568	105	69	10	10	NUM
bjp-19568	105	70	,	,	PUNCT
bjp-19568	105	71	20	20	NUM
bjp-19568	105	72	and	and	CCONJ
bjp-19568	105	73	30	30	NUM
bjp-19568	105	74	µm	µm	NOUN
bjp-19568	105	75	withaferin	withaferin	NOUN
bjp-19568	105	76	a	a	PRON
bjp-19568	105	77	for	for	ADP
bjp-19568	105	78	48	48	NUM
bjp-19568	105	79	hours	hour	NOUN
bjp-19568	105	80	(	(	PUNCT
bjp-19568	105	81	control	control	NOUN
bjp-19568	105	82	:	:	PUNCT
bjp-19568	105	83	cells	cell	NOUN
bjp-19568	105	84	treated	treat	VERB
bjp-19568	105	85	with	with	ADP
bjp-19568	105	86	dimethylsulfoxide	dimethylsulfoxide	ADJ
bjp-19568	105	87	)	)	PUNCT
bjp-19568	105	88	.	.	PUNCT
bjp-19568	106	1	(	(	PUNCT
bjp-19568	106	2	a	a	X
bjp-19568	106	3	)	)	PUNCT
bjp-19568	106	4	the	the	DET
bjp-19568	106	5	mrna	mrna	PROPN
bjp-19568	106	6	levels	level	NOUN
bjp-19568	106	7	in	in	ADP
bjp-19568	106	8	u2os	u2os	NUM
bjp-19568	106	9	and	and	CCONJ
bjp-19568	106	10	mg-63	mg-63	NOUN
bjp-19568	106	11	cells	cell	NOUN
bjp-19568	106	12	treated	treat	VERB
bjp-19568	106	13	with	with	ADP
bjp-19568	106	14	withaferin	withaferin	PROPN
bjp-19568	106	15	a	a	PRON
bjp-19568	106	16	were	be	AUX
bjp-19568	106	17	assessed	assess	VERB
bjp-19568	106	18	by	by	ADP
bjp-19568	106	19	using	use	VERB
bjp-19568	106	20	real	real	ADJ
bjp-19568	106	21	-	-	PUNCT
bjp-19568	106	22	time	time	NOUN
bjp-19568	106	23	rt	rt	ADJ
bjp-19568	106	24	-	-	PUNCT
bjp-19568	106	25	pcr	pcr	NOUN
bjp-19568	106	26	analysis	analysis	NOUN
bjp-19568	106	27	.	.	PUNCT
bjp-19568	107	1	gapdh	gapdh	NOUN
bjp-19568	107	2	was	be	AUX
bjp-19568	107	3	used	use	VERB
bjp-19568	107	4	to	to	PART
bjp-19568	107	5	normalize	normalize	VERB
bjp-19568	107	6	the	the	DET
bjp-19568	107	7	mrna	mrna	PROPN
bjp-19568	107	8	level	level	NOUN
bjp-19568	107	9	.	.	PUNCT
bjp-19568	108	1	the	the	DET
bjp-19568	108	2	results	result	NOUN
bjp-19568	108	3	are	be	AUX
bjp-19568	108	4	presented	present	VERB
bjp-19568	108	5	as	as	ADP
bjp-19568	108	6	the	the	DET
bjp-19568	108	7	percentage	percentage	NOUN
bjp-19568	108	8	relative	relative	ADJ
bjp-19568	108	9	to	to	ADP
bjp-19568	108	10	control	control	VERB
bjp-19568	108	11	.	.	PUNCT
bjp-19568	109	1	the	the	DET
bjp-19568	109	2	expression	expression	NOUN
bjp-19568	109	3	of	of	ADP
bjp-19568	109	4	notch-1	notch-1	PROPN
bjp-19568	109	5	,	,	PUNCT
bjp-19568	109	6	hes-1	hes-1	NOUN
bjp-19568	109	7	,	,	PUNCT
bjp-19568	109	8	hey-1	hey-1	NOUN
bjp-19568	109	9	and	and	CCONJ
bjp-19568	109	10	hey-2	hey-2	VERB
bjp-19568	109	11	genes	gene	NOUN
bjp-19568	109	12	at	at	ADP
bjp-19568	109	13	the	the	DET
bjp-19568	109	14	mrna	mrna	PROPN
bjp-19568	109	15	levels	level	NOUN
bjp-19568	109	16	was	be	AUX
bjp-19568	109	17	down	down	ADV
bjp-19568	109	18	-	-	PUNCT
bjp-19568	109	19	regulated	regulate	VERB
bjp-19568	109	20	after	after	ADP
bjp-19568	109	21	withaferin	withaferin	NOUN
bjp-19568	109	22	a	a	DET
bjp-19568	109	23	treatment	treatment	NOUN
bjp-19568	109	24	.	.	PUNCT
bjp-19568	110	1	(	(	PUNCT
bjp-19568	110	2	b	b	X
bjp-19568	110	3	)	)	PUNCT
bjp-19568	110	4	the	the	DET
bjp-19568	110	5	protein	protein	NOUN
bjp-19568	110	6	levels	level	NOUN
bjp-19568	110	7	in	in	ADP
bjp-19568	110	8	u2os	u2os	NUM
bjp-19568	110	9	and	and	CCONJ
bjp-19568	110	10	mg-63	mg-63	NOUN
bjp-19568	110	11	cells	cell	NOUN
bjp-19568	110	12	treated	treat	VERB
bjp-19568	110	13	with	with	ADP
bjp-19568	110	14	withaferin	withaferin	PROPN
bjp-19568	110	15	a	a	PRON
bjp-19568	110	16	were	be	AUX
bjp-19568	110	17	assessed	assess	VERB
bjp-19568	110	18	by	by	ADP
bjp-19568	110	19	western	western	ADJ
bjp-19568	110	20	blot	blot	NOUN
bjp-19568	110	21	analysis	analysis	NOUN
bjp-19568	110	22	.	.	PUNCT
bjp-19568	111	1	β	β	X
bjp-19568	111	2	-	-	PUNCT
bjp-19568	111	3	actin	actin	NOUN
bjp-19568	111	4	was	be	AUX
bjp-19568	111	5	used	use	VERB
bjp-19568	111	6	as	as	ADP
bjp-19568	111	7	a	a	DET
bjp-19568	111	8	sample	sample	NOUN
bjp-19568	111	9	loading	loading	NOUN
bjp-19568	111	10	control	control	NOUN
bjp-19568	111	11	.	.	PUNCT
bjp-19568	112	1	‘	'	PUNCT
bjp-19568	112	2	notch-1	notch-1	X
bjp-19568	112	3	’	'	PUNCT
bjp-19568	112	4	indicates	indicate	VERB
bjp-19568	112	5	the	the	DET
bjp-19568	112	6	notch-1	notch-1	NUM
bjp-19568	112	7	intracellular	intracellular	ADJ
bjp-19568	112	8	domain	domain	NOUN
bjp-19568	112	9	.	.	PUNCT
bjp-19568	113	1	the	the	DET
bjp-19568	113	2	expression	expression	NOUN
bjp-19568	113	3	of	of	ADP
bjp-19568	113	4	notch-1	notch-1	PROPN
bjp-19568	113	5	,	,	PUNCT
bjp-19568	113	6	hes-1	hes-1	PUNCT
bjp-19568	113	7	and	and	CCONJ
bjp-19568	113	8	cyclin	cyclin	NOUN
bjp-19568	113	9	d1	d1	PROPN
bjp-19568	113	10	at	at	ADP
bjp-19568	113	11	the	the	DET
bjp-19568	113	12	protein	protein	NOUN
bjp-19568	113	13	levels	level	NOUN
bjp-19568	113	14	was	be	AUX
bjp-19568	113	15	down	down	ADV
bjp-19568	113	16	-	-	PUNCT
bjp-19568	113	17	regulated	regulate	VERB
bjp-19568	113	18	after	after	ADP
bjp-19568	113	19	withaferin	withaferin	NOUN
bjp-19568	113	20	a	a	DET
bjp-19568	113	21	treatment	treatment	NOUN
bjp-19568	113	22	.	.	PUNCT
bjp-19568	114	1	data	datum	NOUN
bjp-19568	114	2	are	be	AUX
bjp-19568	114	3	expressed	express	VERB
bjp-19568	114	4	as	as	ADP
bjp-19568	114	5	mean	mean	NOUN
bjp-19568	114	6	±	±	NUM
bjp-19568	114	7	sd	sd	NOUN
bjp-19568	114	8	from	from	ADP
bjp-19568	114	9	three	three	NUM
bjp-19568	114	10	independent	independent	ADJ
bjp-19568	114	11	experiments	experiment	NOUN
bjp-19568	114	12	human	human	ADJ
bjp-19568	114	13	malignancies	malignancy	NOUN
bjp-19568	114	14	,	,	PUNCT
bjp-19568	114	15	including	include	VERB
bjp-19568	114	16	osteosarcoma	osteosarcoma	ADJ
bjp-19568	114	17	(	(	PUNCT
bjp-19568	114	18	zhang	zhang	X
bjp-19568	114	19	et	et	PROPN
bjp-19568	114	20	al	al	PROPN
bjp-19568	114	21	.	.	PROPN
bjp-19568	114	22	,	,	PUNCT
bjp-19568	114	23	2008	2008	NUM
bjp-19568	114	24	;	;	PUNCT
bjp-19568	115	1	wang	wang	PROPN
bjp-19568	115	2	et	et	PROPN
bjp-19568	115	3	al	al	PROPN
bjp-19568	115	4	.	.	PROPN
bjp-19568	115	5	,	,	PUNCT
bjp-19568	115	6	2008	2008	NUM
bjp-19568	115	7	;	;	PUNCT
bjp-19568	115	8	engin	engin	PROPN
bjp-19568	115	9	et	et	PROPN
bjp-19568	115	10	al	al	PROPN
bjp-19568	115	11	.	.	PROPN
bjp-19568	115	12	,	,	PUNCT
bjp-19568	115	13	2009	2009	NUM
bjp-19568	115	14	;	;	PUNCT
bjp-19568	115	15	tanaka	tanaka	PROPN
bjp-19568	115	16	et	et	PROPN
bjp-19568	115	17	al	al	PROPN
bjp-19568	115	18	.	.	PROPN
bjp-19568	115	19	,	,	PUNCT
bjp-19568	115	20	2009	2009	NUM
bjp-19568	115	21	;	;	PUNCT
bjp-19568	115	22	hughes	hughe	NOUN
bjp-19568	115	23	,	,	PUNCT
bjp-19568	115	24	2009	2009	NUM
bjp-19568	115	25	)	)	PUNCT
bjp-19568	115	26	.	.	PUNCT
bjp-19568	116	1	there	there	PRON
bjp-19568	116	2	is	be	VERB
bjp-19568	116	3	evidence	evidence	NOUN
bjp-19568	116	4	that	that	SCONJ
bjp-19568	116	5	notch	notch	VERB
bjp-19568	116	6	pathway	pathway	NOUN
bjp-19568	116	7	components	component	NOUN
bjp-19568	116	8	and	and	CCONJ
bjp-19568	116	9	its	its	PRON
bjp-19568	116	10	target	target	NOUN
bjp-19568	116	11	genes	gene	NOUN
bjp-19568	116	12	are	be	AUX
bjp-19568	116	13	upregulated	upregulate	VERB
bjp-19568	116	14	in	in	ADP
bjp-19568	116	15	human	human	ADJ
bjp-19568	116	16	pancreatic	pancreatic	ADJ
bjp-19568	116	17	cancer	cancer	NOUN
bjp-19568	116	18	cells	cell	NOUN
bjp-19568	116	19	and	and	CCONJ
bjp-19568	116	20	inactivation	inactivation	NOUN
bjp-19568	116	21	of	of	ADP
bjp-19568	116	22	notch-1	notch-1	NUM
bjp-19568	116	23	by	by	ADP
bjp-19568	116	24	sirna	sirna	PROPN
bjp-19568	116	25	induced	induce	VERB
bjp-19568	116	26	down	down	ADP
bjp-19568	116	27	-	-	PUNCT
bjp-19568	116	28	regulation	regulation	NOUN
bjp-19568	116	29	of	of	ADP
bjp-19568	116	30	bcl-2	bcl-2	NOUN
bjp-19568	116	31	,	,	PUNCT
bjp-19568	116	32	bcl	bcl	PROPN
bjp-19568	116	33	-	-	PROPN
bjp-19568	116	34	xl	xl	PROPN
bjp-19568	116	35	,	,	PUNCT
bjp-19568	116	36	cyclin	cyclin	PROPN
bjp-19568	116	37	a	a	X
bjp-19568	116	38	,	,	PUNCT
bjp-19568	116	39	cyclin	cyclin	NOUN
bjp-19568	116	40	d1	d1	PROPN
bjp-19568	116	41	and	and	CCONJ
bjp-19568	116	42	cyclindependent	cyclindependent	VERB
bjp-19568	116	43	kinase	kinase	PROPN
bjp-19568	116	44	2	2	NUM
bjp-19568	116	45	,	,	PUNCT
bjp-19568	116	46	as	as	ADV
bjp-19568	116	47	well	well	ADV
bjp-19568	116	48	as	as	ADP
bjp-19568	116	49	up	up	ADP
bjp-19568	116	50	-	-	PUNCT
bjp-19568	116	51	regulation	regulation	NOUN
bjp-19568	116	52	of	of	ADP
bjp-19568	116	53	p21	p21	NOUN
bjp-19568	116	54	and	and	CCONJ
bjp-19568	116	55	p27	p27	NOUN
bjp-19568	116	56	,	,	PUNCT
bjp-19568	116	57	resulting	result	VERB
bjp-19568	116	58	in	in	ADP
bjp-19568	116	59	cell	cell	NOUN
bjp-19568	116	60	growth	growth	NOUN
bjp-19568	116	61	inhibition	inhibition	NOUN
bjp-19568	116	62	and	and	CCONJ
bjp-19568	116	63	apoptosis	apoptosis	NOUN
bjp-19568	116	64	(	(	PUNCT
bjp-19568	116	65	wang	wang	PROPN
bjp-19568	116	66	et	et	PROPN
bjp-19568	116	67	al	al	PROPN
bjp-19568	116	68	.	.	PROPN
bjp-19568	116	69	,	,	PUNCT
bjp-19568	116	70	2008	2008	NUM
bjp-19568	116	71	)	)	PUNCT
bjp-19568	116	72	.	.	PUNCT
bjp-19568	117	1	jang	jang	PROPN
bjp-19568	117	2	et	et	PROPN
bjp-19568	117	3	al	al	PROPN
bjp-19568	117	4	.	.	PROPN
bjp-19568	117	5	also	also	ADV
bjp-19568	117	6	reports	report	VERB
bjp-19568	117	7	that	that	SCONJ
bjp-19568	117	8	notch-1	notch-1	NUM
bjp-19568	117	9	expression	expression	NOUN
bjp-19568	117	10	regulates	regulate	VERB
bjp-19568	117	11	cell	cell	NOUN
bjp-19568	117	12	death	death	NOUN
bjp-19568	117	13	through	through	ADP
bjp-19568	117	14	both	both	CCONJ
bjp-19568	117	15	apoptosis	apoptosis	NOUN
bjp-19568	117	16	and	and	CCONJ
bjp-19568	117	17	cell	cell	NOUN
bjp-19568	117	18	cycle	cycle	NOUN
bjp-19568	117	19	pathways	pathway	NOUN
bjp-19568	117	20	in	in	ADP
bjp-19568	117	21	erythroleukemia	erythroleukemia	NOUN
bjp-19568	117	22	cells	cell	NOUN
bjp-19568	117	23	and	and	CCONJ
bjp-19568	117	24	is	be	AUX
bjp-19568	117	25	associated	associate	VERB
bjp-19568	117	26	in	in	ADP
bjp-19568	117	27	part	part	NOUN
bjp-19568	117	28	with	with	ADP
bjp-19568	117	29	the	the	DET
bjp-19568	117	30	regulation	regulation	NOUN
bjp-19568	117	31	of	of	ADP
bjp-19568	117	32	bcl	bcl	PROPN
bjp-19568	117	33	-	-	PROPN
bjp-19568	117	34	xl	xl	PROPN
bjp-19568	117	35	,	,	PUNCT
bjp-19568	117	36	p21	p21	NOUN
bjp-19568	117	37	,	,	PUNCT
bjp-19568	117	38	p27	p27	NOUN
bjp-19568	117	39	and	and	CCONJ
bjp-19568	117	40	nf	nf	PROPN
bjp-19568	117	41	-	-	PUNCT
bjp-19568	117	42	jb	jb	NOUN
bjp-19568	117	43	.	.	PUNCT
bjp-19568	118	1	recent	recent	ADJ
bjp-19568	118	2	results	result	NOUN
bjp-19568	118	3	have	have	AUX
bjp-19568	118	4	shown	show	VERB
bjp-19568	118	5	that	that	SCONJ
bjp-19568	118	6	notch	notch	NOUN
bjp-19568	118	7	signaling	signal	VERB
bjp-19568	118	8	is	be	AUX
bjp-19568	118	9	involved	involve	VERB
bjp-19568	118	10	in	in	ADP
bjp-19568	118	11	osteosarcoma	osteosarcoma	ADJ
bjp-19568	118	12	cell	cell	NOUN
bjp-19568	118	13	survival	survival	NOUN
bjp-19568	118	14	and	and	CCONJ
bjp-19568	118	15	contributes	contribute	VERB
bjp-19568	118	16	to	to	ADP
bjp-19568	118	17	the	the	DET
bjp-19568	118	18	pathogenesis	pathogenesis	NOUN
bjp-19568	118	19	of	of	ADP
bjp-19568	118	20	human	human	ADJ
bjp-19568	118	21	osteosarcoma	osteosarcoma	NOUN
bjp-19568	118	22	.	.	PUNCT
bjp-19568	119	1	inhibition	inhibition	NOUN
bjp-19568	119	2	of	of	ADP
bjp-19568	119	3	the	the	DET
bjp-19568	119	4	notch	notch	ADJ
bjp-19568	119	5	pathway	pathway	NOUN
bjp-19568	119	6	by	by	ADP
bjp-19568	119	7	c	c	NOUN
bjp-19568	119	8	-	-	PUNCT
bjp-19568	119	9	secretase	secretase	ADJ
bjp-19568	119	10	inhibitor	inhibitor	NOUN
bjp-19568	119	11	treatment	treatment	NOUN
bjp-19568	119	12	prevents	prevent	VERB
bjp-19568	119	13	osteosarcoma	osteosarcoma	ADJ
bjp-19568	119	14	growth	growth	NOUN
bjp-19568	119	15	in	in	ADP
bjp-19568	119	16	vitro	vitro	X
bjp-19568	119	17	and	and	CCONJ
bjp-19568	119	18	in	in	ADP
bjp-19568	119	19	vivo	vivo	NOUN
bjp-19568	119	20	by	by	ADP
bjp-19568	119	21	cell	cell	NOUN
bjp-19568	119	22	cycle	cycle	NOUN
bjp-19568	119	23	regulation	regulation	NOUN
bjp-19568	119	24	(	(	PUNCT
bjp-19568	119	25	engin	engin	PROPN
bjp-19568	119	26	et	et	PROPN
bjp-19568	119	27	al	al	PROPN
bjp-19568	119	28	.	.	PROPN
bjp-19568	119	29	,	,	PUNCT
bjp-19568	119	30	2009	2009	NUM
bjp-19568	119	31	)	)	PUNCT
bjp-19568	119	32	.	.	PUNCT
bjp-19568	120	1	in	in	ADP
bjp-19568	120	2	addition	addition	NOUN
bjp-19568	120	3	,	,	PUNCT
bjp-19568	120	4	zhang	zhang	PROPN
bjp-19568	120	5	et	et	PROPN
bjp-19568	120	6	al	al	PROPN
bjp-19568	120	7	.	.	PROPN
bjp-19568	120	8	reveals	reveal	VERB
bjp-19568	120	9	a	a	DET
bjp-19568	120	10	specific	specific	ADJ
bjp-19568	120	11	and	and	CCONJ
bjp-19568	120	12	essential	essential	ADJ
bjp-19568	120	13	role	role	NOUN
bjp-19568	120	14	of	of	ADP
bjp-19568	120	15	notch	notch	NOUN
bjp-19568	120	16	signaling	signal	VERB
bjp-19568	120	17	in	in	ADP
bjp-19568	120	18	promoting	promote	VERB
bjp-19568	120	19	osteosarcoma	osteosarcoma	ADJ
bjp-19568	120	20	invasiveness	invasiveness	NOUN
bjp-19568	120	21	and	and	CCONJ
bjp-19568	120	22	metastasis	metastasis	NOUN
bjp-19568	120	23	in	in	ADP
bjp-19568	120	24	vitro	vitro	X
bjp-19568	120	25	and	and	CCONJ
bjp-19568	120	26	in	in	ADP
bjp-19568	120	27	vivo	vivo	NOUN
bjp-19568	120	28	.	.	PUNCT
bjp-19568	121	1	therefore	therefore	ADV
bjp-19568	121	2	,	,	PUNCT
bjp-19568	121	3	inhibition	inhibition	NOUN
bjp-19568	121	4	of	of	ADP
bjp-19568	121	5	notch	notch	NOUN
bjp-19568	121	6	signaling	signal	VERB
bjp-19568	121	7	may	may	AUX
bjp-19568	121	8	have	have	VERB
bjp-19568	121	9	important	important	ADJ
bjp-19568	121	10	therapeutic	therapeutic	ADJ
bjp-19568	121	11	applications	application	NOUN
bjp-19568	121	12	for	for	ADP
bjp-19568	121	13	treating	treat	VERB
bjp-19568	121	14	and	and	CCONJ
bjp-19568	121	15	preventing	prevent	VERB
bjp-19568	121	16	osteosarcoma	osteosarcoma	ADJ
bjp-19568	121	17	metastasis	metastasis	NOUN
bjp-19568	121	18	.	.	PUNCT
bjp-19568	122	1	recently	recently	ADV
bjp-19568	122	2	,	,	PUNCT
bjp-19568	122	3	withaferin	withaferin	NOUN
bjp-19568	122	4	a	a	PRON
bjp-19568	122	5	has	have	AUX
bjp-19568	122	6	been	be	AUX
bjp-19568	122	7	shown	show	VERB
bjp-19568	122	8	to	to	PART
bjp-19568	122	9	possess	possess	VERB
bjp-19568	122	10	potent	potent	ADJ
bjp-19568	122	11	antineoplastic	antineoplastic	ADJ
bjp-19568	122	12	activity	activity	NOUN
bjp-19568	122	13	in	in	ADP
bjp-19568	122	14	vitro	vitro	X
bjp-19568	122	15	and	and	CCONJ
bjp-19568	122	16	in	in	ADP
bjp-19568	122	17	vivo	vivo	NOUN
bjp-19568	122	18	against	against	ADP
bjp-19568	122	19	a	a	DET
bjp-19568	122	20	variety	variety	NOUN
bjp-19568	122	21	of	of	ADP
bjp-19568	122	22	malignancies	malignancy	NOUN
bjp-19568	122	23	,	,	PUNCT
bjp-19568	122	24	including	include	VERB
bjp-19568	122	25	prostate	prostate	NOUN
bjp-19568	122	26	,	,	PUNCT
bjp-19568	122	27	breast	breast	NOUN
bjp-19568	122	28	and	and	CCONJ
bjp-19568	122	29	colon	colon	NOUN
bjp-19568	122	30	cancer	cancer	NOUN
bjp-19568	122	31	(	(	PUNCT
bjp-19568	122	32	srinivasan	srinivasan	NOUN
bjp-19568	122	33	et	et	PROPN
bjp-19568	122	34	al	al	PROPN
bjp-19568	122	35	.	.	PROPN
bjp-19568	122	36	,	,	PUNCT
bjp-19568	122	37	2007	2007	NUM
bjp-19568	122	38	;	;	PUNCT
bjp-19568	122	39	stan	stan	PROPN
bjp-19568	122	40	et	et	PROPN
bjp-19568	122	41	al	al	PROPN
bjp-19568	122	42	.	.	PROPN
bjp-19568	122	43	,	,	PUNCT
bjp-19568	122	44	2008	2008	NUM
bjp-19568	122	45	;	;	PUNCT
bjp-19568	122	46	koduru	koduru	PROPN
bjp-19568	122	47	et	et	PROPN
bjp-19568	122	48	al	al	PROPN
bjp-19568	122	49	.	.	PROPN
bjp-19568	122	50	,	,	PUNCT
bjp-19568	122	51	2010	2010	NUM
bjp-19568	122	52	)	)	PUNCT
bjp-19568	122	53	.	.	PUNCT
bjp-19568	123	1	withaferin	withaferin	PROPN
bjp-19568	123	2	a	a	PRON
bjp-19568	123	3	is	be	AUX
bjp-19568	123	4	known	know	VERB
bjp-19568	123	5	to	to	PART
bjp-19568	123	6	target	target	VERB
bjp-19568	123	7	multiple	multiple	ADJ
bjp-19568	123	8	biochemical	biochemical	ADJ
bjp-19568	123	9	pathways	pathway	NOUN
bjp-19568	123	10	,	,	PUNCT
bjp-19568	123	11	such	such	ADJ
bjp-19568	123	12	as	as	ADP
bjp-19568	123	13	those	those	PRON
bjp-19568	123	14	mediated	mediate	VERB
bjp-19568	123	15	by	by	ADP
bjp-19568	123	16	nfjb	nfjb	NOUN
bjp-19568	123	17	,	,	PUNCT
bjp-19568	123	18	akt	akt	PROPN
bjp-19568	123	19	,	,	PUNCT
bjp-19568	123	20	jak⁄	jak⁄	PROPN
bjp-19568	123	21	stat	stat	PROPN
bjp-19568	123	22	,	,	PUNCT
bjp-19568	123	23	the	the	DET
bjp-19568	123	24	wnt	wnt	PROPN
bjp-19568	123	25	⁄b	⁄b	PROPN
bjp-19568	123	26	-	-	PUNCT
bjp-19568	123	27	catenin	catenin	NOUN
bjp-19568	123	28	pathway	pathway	NOUN
bjp-19568	123	29	and	and	CCONJ
bjp-19568	123	30	growth	growth	NOUN
bjp-19568	123	31	(	(	PUNCT
bjp-19568	123	32	ichikawa	ichikawa	NOUN
bjp-19568	123	33	et	et	PROPN
bjp-19568	123	34	al	al	PROPN
bjp-19568	123	35	.	.	PROPN
bjp-19568	123	36	,	,	PUNCT
bjp-19568	123	37	2006	2006	NUM
bjp-19568	123	38	)	)	PUNCT
bjp-19568	123	39	.	.	PUNCT
bjp-19568	124	1	in	in	ADP
bjp-19568	124	2	summary	summary	NOUN
bjp-19568	124	3	,	,	PUNCT
bjp-19568	124	4	we	we	PRON
bjp-19568	124	5	have	have	AUX
bjp-19568	124	6	presented	present	VERB
bjp-19568	124	7	experimental	experimental	ADJ
bjp-19568	124	8	evidence	evidence	NOUN
bjp-19568	124	9	that	that	PRON
bjp-19568	124	10	supports	support	VERB
bjp-19568	124	11	the	the	DET
bjp-19568	124	12	role	role	NOUN
bjp-19568	124	13	of	of	ADP
bjp-19568	124	14	withaferin	withaferin	NOUN
bjp-19568	124	15	a	a	PRON
bjp-19568	124	16	as	as	ADP
bjp-19568	124	17	an	an	DET
bjp-19568	124	18	antitumor	antitumor	PROPN
bjp-19568	124	19	agent	agent	NOUN
bjp-19568	124	20	.	.	PUNCT
bjp-19568	125	1	on	on	ADP
bjp-19568	125	2	the	the	DET
bjp-19568	125	3	basis	basis	NOUN
bjp-19568	125	4	of	of	ADP
bjp-19568	125	5	our	our	PRON
bjp-19568	125	6	results	result	NOUN
bjp-19568	125	7	,	,	PUNCT
bjp-19568	125	8	we	we	PRON
bjp-19568	125	9	propose	propose	VERB
bjp-19568	125	10	a	a	DET
bjp-19568	125	11	hypothesis	hypothesis	NOUN
bjp-19568	125	12	that	that	PRON
bjp-19568	125	13	withaferin	withaferin	NOUN
bjp-19568	125	14	a	a	PRON
bjp-19568	125	15	-	-	PUNCT
bjp-19568	125	16	mediated	mediate	VERB
bjp-19568	125	17	inhibition	inhibition	NOUN
bjp-19568	125	18	of	of	ADP
bjp-19568	125	19	cell	cell	NOUN
bjp-19568	125	20	growth	growth	NOUN
bjp-19568	125	21	and	and	CCONJ
bjp-19568	125	22	invasion	invasion	NOUN
bjp-19568	125	23	is	be	AUX
bjp-19568	125	24	associated	associate	VERB
bjp-19568	125	25	with	with	ADP
bjp-19568	125	26	inactivation	inactivation	NOUN
bjp-19568	125	27	of	of	ADP
bjp-19568	125	28	notch-1	notch-1	NUM
bjp-19568	125	29	and	and	CCONJ
bjp-19568	125	30	its	its	PRON
bjp-19568	125	31	downstream	downstream	ADJ
bjp-19568	125	32	target	target	NOUN
bjp-19568	125	33	gene	gene	NOUN
bjp-19568	125	34	mmps	mmp	NOUN
bjp-19568	125	35	.	.	PUNCT
bjp-19568	126	1	the	the	DET
bjp-19568	126	2	molecular	molecular	ADJ
bjp-19568	126	3	mechanisms	mechanism	NOUN
bjp-19568	126	4	by	by	ADP
bjp-19568	126	5	which	which	DET
bjp-19568	126	6	withaferin	withaferin	NOUN
bjp-19568	126	7	a	a	DET
bjp-19568	126	8	exerts	exert	VERB
bjp-19568	126	9	its	its	PRON
bjp-19568	126	10	antitumor	antitumor	PROPN
bjp-19568	126	11	activity	activity	NOUN
bjp-19568	126	12	in	in	ADP
bjp-19568	126	13	osteosarcoma	osteosarcoma	ADJ
bjp-19568	126	14	cells	cell	NOUN
bjp-19568	126	15	,	,	PUNCT
bjp-19568	126	16	as	as	SCONJ
bjp-19568	126	17	revealed	reveal	VERB
bjp-19568	126	18	in	in	ADP
bjp-19568	126	19	our	our	PRON
bjp-19568	126	20	study	study	NOUN
bjp-19568	126	21	,	,	PUNCT
bjp-19568	126	22	has	have	AUX
bjp-19568	126	23	opened	open	VERB
bjp-19568	126	24	up	up	ADP
bjp-19568	126	25	exciting	exciting	ADJ
bjp-19568	126	26	new	new	ADJ
bjp-19568	126	27	avenues	avenue	NOUN
bjp-19568	126	28	for	for	ADP
bjp-19568	126	29	devising	devise	VERB
bjp-19568	126	30	novel	novel	ADJ
bjp-19568	126	31	therapeutic	therapeutic	ADJ
bjp-19568	126	32	strategies	strategy	NOUN
bjp-19568	126	33	.	.	PUNCT
bjp-19568	127	1	the	the	DET
bjp-19568	127	2	down	down	ADV
bjp-19568	127	3	-	-	PUNCT
bjp-19568	127	4	regulabangladesh	regulabangladesh	NOUN
bjp-19568	127	5	j	j	PROPN
bjp-19568	127	6	pharmacol	pharmacol	PROPN
bjp-19568	127	7	2014	2014	NUM
bjp-19568	127	8	;	;	PUNCT
bjp-19568	127	9	9	9	NUM
bjp-19568	127	10	:	:	SYM
bjp-19568	127	11	364	364	NUM
bjp-19568	127	12	-	-	SYM
bjp-19568	127	13	370	370	NUM
bjp-19568	127	14	369	369	NUM
bjp-19568	127	15	figure	figure	NOUN
bjp-19568	127	16	4	4	NUM
bjp-19568	127	17	:	:	PUNCT
bjp-19568	127	18	the	the	DET
bjp-19568	127	19	mrna	mrna	PROPN
bjp-19568	127	20	(	(	PUNCT
bjp-19568	127	21	a	a	NOUN
bjp-19568	127	22	)	)	PUNCT
bjp-19568	127	23	and	and	CCONJ
bjp-19568	127	24	protein	protein	NOUN
bjp-19568	127	25	levels	level	NOUN
bjp-19568	127	26	(	(	PUNCT
bjp-19568	127	27	b	b	NOUN
bjp-19568	127	28	)	)	PUNCT
bjp-19568	127	29	in	in	ADP
bjp-19568	127	30	withaferin	withaferin	PROPN
bjp-19568	127	31	a	a	ADV
bjp-19568	127	32	-	-	PUNCT
bjp-19568	127	33	treated	treat	VERB
bjp-19568	127	34	cells	cell	NOUN
bjp-19568	127	35	were	be	AUX
bjp-19568	127	36	assessed	assess	VERB
bjp-19568	127	37	using	use	VERB
bjp-19568	127	38	real	real	ADJ
bjp-19568	127	39	-	-	PUNCT
bjp-19568	127	40	time	time	NOUN
bjp-19568	127	41	rt	rt	NOUN
bjp-19568	127	42	-	-	PUNCT
bjp-19568	127	43	pcr	pcr	ADJ
bjp-19568	127	44	and	and	CCONJ
bjp-19568	127	45	western	western	ADJ
bjp-19568	127	46	blot	blot	NOUN
bjp-19568	127	47	analysis	analysis	NOUN
bjp-19568	127	48	,	,	PUNCT
bjp-19568	127	49	respectively	respectively	ADV
bjp-19568	127	50	gapdh	gapdh	NOUN
bjp-19568	127	51	was	be	AUX
bjp-19568	127	52	used	use	VERB
bjp-19568	127	53	to	to	PART
bjp-19568	127	54	normalize	normalize	VERB
bjp-19568	127	55	the	the	DET
bjp-19568	127	56	mrna	mrna	PROPN
bjp-19568	127	57	level	level	NOUN
bjp-19568	127	58	.	.	PUNCT
bjp-19568	128	1	the	the	DET
bjp-19568	128	2	results	result	NOUN
bjp-19568	128	3	are	be	AUX
bjp-19568	128	4	presented	present	VERB
bjp-19568	128	5	as	as	ADP
bjp-19568	128	6	the	the	DET
bjp-19568	128	7	percentage	percentage	NOUN
bjp-19568	128	8	relative	relative	ADJ
bjp-19568	128	9	to	to	ADP
bjp-19568	128	10	control	control	VERB
bjp-19568	128	11	.	.	PUNCT
bjp-19568	129	1	β	β	X
bjp-19568	129	2	-	-	PUNCT
bjp-19568	129	3	actin	actin	NOUN
bjp-19568	129	4	was	be	AUX
bjp-19568	129	5	used	use	VERB
bjp-19568	129	6	as	as	ADP
bjp-19568	129	7	a	a	DET
bjp-19568	129	8	sample	sample	NOUN
bjp-19568	129	9	loading	loading	NOUN
bjp-19568	129	10	control	control	NOUN
bjp-19568	129	11	.	.	PUNCT
bjp-19568	130	1	the	the	DET
bjp-19568	130	2	expression	expression	NOUN
bjp-19568	130	3	of	of	ADP
bjp-19568	130	4	mmp-2	mmp-2	NUM
bjp-19568	130	5	and	and	CCONJ
bjp-19568	130	6	mmp-9	mmp-9	NOUN
bjp-19568	130	7	genes	gene	NOUN
bjp-19568	130	8	both	both	CCONJ
bjp-19568	130	9	at	at	ADP
bjp-19568	130	10	the	the	DET
bjp-19568	130	11	mrna	mrna	NOUN
bjp-19568	130	12	and	and	CCONJ
bjp-19568	130	13	protein	protein	NOUN
bjp-19568	130	14	levels	level	NOUN
bjp-19568	130	15	was	be	AUX
bjp-19568	130	16	dose	dose	VERB
bjp-19568	130	17	-	-	PUNCT
bjp-19568	130	18	dependently	dependently	ADV
bjp-19568	130	19	reduced	reduce	VERB
bjp-19568	130	20	with	with	ADP
bjp-19568	130	21	withaferin	withaferin	NOUN
bjp-19568	130	22	a	a	DET
bjp-19568	130	23	treatment	treatment	NOUN
bjp-19568	130	24	tion	tion	NOUN
bjp-19568	130	25	of	of	ADP
bjp-19568	130	26	notch-1	notch-1	NUM
bjp-19568	130	27	and	and	CCONJ
bjp-19568	130	28	mmps	mmp	NOUN
bjp-19568	130	29	by	by	ADP
bjp-19568	130	30	withaferin	withaferin	NOUN
bjp-19568	130	31	a	a	PRON
bjp-19568	130	32	may	may	AUX
bjp-19568	130	33	be	be	AUX
bjp-19568	130	34	a	a	DET
bjp-19568	130	35	useful	useful	ADJ
bjp-19568	130	36	strategy	strategy	NOUN
bjp-19568	130	37	for	for	ADP
bjp-19568	130	38	chemosensitization	chemosensitization	NOUN
bjp-19568	130	39	of	of	ADP
bjp-19568	130	40	metastatic	metastatic	ADJ
bjp-19568	130	41	osteosarcoma	osteosarcoma	ADJ
bjp-19568	130	42	cells	cell	NOUN
bjp-19568	130	43	to	to	ADP
bjp-19568	130	44	standard	standard	ADJ
bjp-19568	130	45	therapeutics	therapeutic	NOUN
bjp-19568	130	46	.	.	PUNCT
bjp-19568	131	1	references	reference	NOUN
bjp-19568	131	2	arndt	arndt	PROPN
bjp-19568	131	3	ca	ca	PROPN
bjp-19568	131	4	,	,	PUNCT
bjp-19568	131	5	crist	crist	PROPN
bjp-19568	131	6	wm	wm	PROPN
bjp-19568	131	7	.	.	PROPN
bjp-19568	132	1	common	common	ADJ
bjp-19568	132	2	musculoskeletal	musculoskeletal	ADJ
bjp-19568	132	3	tumors	tumor	NOUN
bjp-19568	132	4	of	of	ADP
bjp-19568	132	5	childhood	childhood	NOUN
bjp-19568	132	6	and	and	CCONJ
bjp-19568	132	7	adolescence	adolescence	NOUN
bjp-19568	132	8	.	.	PUNCT
bjp-19568	133	1	n	n	PROPN
bjp-19568	133	2	engl	engl	PROPN
bjp-19568	133	3	j	j	PROPN
bjp-19568	133	4	med	med	PROPN
bjp-19568	133	5	.	.	PUNCT
bjp-19568	133	6	1999	1999	NUM
bjp-19568	133	7	;	;	PUNCT
bjp-19568	133	8	341	341	NUM
bjp-19568	133	9	:	:	PUNCT
bjp-19568	133	10	342	342	NUM
bjp-19568	133	11	-	-	SYM
bjp-19568	133	12	52	52	NUM
bjp-19568	133	13	.	.	PUNCT
bjp-19568	134	1	bielack	bielack	PROPN
bjp-19568	134	2	ss	ss	PROPN
bjp-19568	134	3	,	,	PUNCT
bjp-19568	134	4	kempf	kempf	PROPN
bjp-19568	134	5	-	-	PUNCT
bjp-19568	134	6	bielack	bielack	NOUN
bjp-19568	134	7	b	b	NOUN
bjp-19568	134	8	,	,	PUNCT
bjp-19568	134	9	delling	delle	VERB
bjp-19568	134	10	g	g	NOUN
bjp-19568	134	11	,	,	PUNCT
bjp-19568	134	12	exner	exner	NOUN
bjp-19568	134	13	gu	gu	NOUN
bjp-19568	134	14	,	,	PUNCT
bjp-19568	134	15	flege	flege	PROPN
bjp-19568	134	16	s	s	PROPN
bjp-19568	134	17	,	,	PUNCT
bjp-19568	134	18	helmke	helmke	PROPN
bjp-19568	134	19	k	k	PROPN
bjp-19568	134	20	,	,	PUNCT
bjp-19568	134	21	kotz	kotz	PROPN
bjp-19568	134	22	r	r	PROPN
bjp-19568	134	23	,	,	PUNCT
bjp-19568	134	24	salzer	salzer	NOUN
bjp-19568	134	25	-	-	PUNCT
bjp-19568	134	26	kuntschik	kuntschik	NOUN
bjp-19568	134	27	m	m	PROPN
bjp-19568	134	28	,	,	PUNCT
bjp-19568	134	29	werner	werner	PROPN
bjp-19568	134	30	m	m	PROPN
bjp-19568	134	31	,	,	PUNCT
bjp-19568	134	32	winkelmann	winkelmann	PROPN
bjp-19568	134	33	w	w	PROPN
bjp-19568	134	34	,	,	PUNCT
bjp-19568	134	35	zoubek	zoubek	PROPN
bjp-19568	134	36	a	a	NOUN
bjp-19568	134	37	,	,	PUNCT
bjp-19568	134	38	jurgens	jurgens	PROPN
bjp-19568	134	39	h	h	PROPN
bjp-19568	134	40	,	,	PUNCT
bjp-19568	134	41	winkler	winkler	PROPN
bjp-19568	134	42	k.	k.	PROPN
bjp-19568	135	1	prognostic	prognostic	PROPN
bjp-19568	135	2	factors	factor	NOUN
bjp-19568	135	3	in	in	ADP
bjp-19568	135	4	high	high	ADJ
bjp-19568	135	5	-	-	PUNCT
bjp-19568	135	6	grade	grade	NOUN
bjp-19568	135	7	osteosarcoma	osteosarcoma	NOUN
bjp-19568	135	8	of	of	ADP
bjp-19568	135	9	the	the	DET
bjp-19568	135	10	extremities	extremity	NOUN
bjp-19568	135	11	or	or	CCONJ
bjp-19568	135	12	trunk	trunk	NOUN
bjp-19568	135	13	:	:	PUNCT
bjp-19568	135	14	an	an	DET
bjp-19568	135	15	analysis	analysis	NOUN
bjp-19568	135	16	of	of	ADP
bjp-19568	135	17	1,702	1,702	NUM
bjp-19568	135	18	patients	patient	NOUN
bjp-19568	135	19	treated	treat	VERB
bjp-19568	135	20	on	on	ADP
bjp-19568	135	21	neoadjuvant	neoadjuvant	ADJ
bjp-19568	135	22	cooperative	cooperative	ADJ
bjp-19568	135	23	osteosarcoma	osteosarcoma	ADJ
bjp-19568	135	24	study	study	NOUN
bjp-19568	135	25	group	group	NOUN
bjp-19568	135	26	protocols	protocol	NOUN
bjp-19568	135	27	.	.	PUNCT
bjp-19568	136	1	j	j	PROPN
bjp-19568	136	2	clin	clin	PROPN
bjp-19568	136	3	oncol	oncol	PROPN
bjp-19568	136	4	.	.	PUNCT
bjp-19568	137	1	2002	2002	NUM
bjp-19568	137	2	;	;	PUNCT
bjp-19568	137	3	20	20	NUM
bjp-19568	137	4	:	:	PUNCT
bjp-19568	137	5	776	776	NUM
bjp-19568	137	6	-	-	SYM
bjp-19568	137	7	90	90	NUM
bjp-19568	137	8	.	.	PUNCT
bjp-19568	138	1	engin	engin	PROPN
bjp-19568	138	2	f	f	PROPN
bjp-19568	138	3	,	,	PUNCT
bjp-19568	138	4	bertin	bertin	PROPN
bjp-19568	138	5	t	t	PROPN
bjp-19568	138	6	,	,	PUNCT
bjp-19568	138	7	ma	ma	PROPN
bjp-19568	138	8	o	o	PROPN
bjp-19568	138	9	,	,	PUNCT
bjp-19568	138	10	jiang	jiang	PROPN
bjp-19568	138	11	mm	mm	PROPN
bjp-19568	138	12	,	,	PUNCT
bjp-19568	138	13	wang	wang	PROPN
bjp-19568	138	14	l	l	PROPN
bjp-19568	138	15	,	,	PUNCT
bjp-19568	138	16	sutton	sutton	PROPN
bjp-19568	138	17	re	re	PROPN
bjp-19568	138	18	,	,	PUNCT
bjp-19568	138	19	a	a	DET
bjp-19568	138	20	donehower	donehower	NOUN
bjp-19568	138	21	l	l	NOUN
bjp-19568	138	22	,	,	PUNCT
bjp-19568	138	23	lee	lee	PROPN
bjp-19568	138	24	b.	b.	PROPN
bjp-19568	138	25	notch	notch	PROPN
bjp-19568	138	26	signaling	signal	VERB
bjp-19568	138	27	contributes	contribute	VERB
bjp-19568	138	28	to	to	ADP
bjp-19568	138	29	the	the	DET
bjp-19568	138	30	pathogenesis	pathogenesis	NOUN
bjp-19568	138	31	of	of	ADP
bjp-19568	138	32	human	human	ADJ
bjp-19568	138	33	osteosarcomas	osteosarcomas	PROPN
bjp-19568	138	34	.	.	PUNCT
bjp-19568	139	1	hum	hum	PROPN
bjp-19568	139	2	mol	mol	ADP
bjp-19568	139	3	genet	genet	PROPN
bjp-19568	139	4	.	.	PUNCT
bjp-19568	140	1	2009	2009	NUM
bjp-19568	140	2	;	;	PUNCT
bjp-19568	140	3	18	18	NUM
bjp-19568	140	4	:	:	SYM
bjp-19568	140	5	1464	1464	NUM
bjp-19568	140	6	-	-	SYM
bjp-19568	140	7	70	70	NUM
bjp-19568	140	8	.	.	PUNCT
bjp-19568	141	1	hughes	hughe	NOUN
bjp-19568	141	2	dp	dp	PROPN
bjp-19568	141	3	.	.	PUNCT
bjp-19568	142	1	how	how	SCONJ
bjp-19568	142	2	the	the	DET
bjp-19568	142	3	notch	notch	ADJ
bjp-19568	142	4	pathway	pathway	NOUN
bjp-19568	142	5	contributes	contribute	VERB
bjp-19568	142	6	to	to	ADP
bjp-19568	142	7	the	the	DET
bjp-19568	142	8	ability	ability	NOUN
bjp-19568	142	9	of	of	ADP
bjp-19568	142	10	osteosarcoma	osteosarcoma	ADJ
bjp-19568	142	11	cells	cell	NOUN
bjp-19568	142	12	to	to	PART
bjp-19568	142	13	metastasize	metastasize	VERB
bjp-19568	142	14	.	.	PUNCT
bjp-19568	143	1	cancer	cancer	NOUN
bjp-19568	143	2	treat	treat	NOUN
bjp-19568	143	3	res	re	NOUN
bjp-19568	143	4	.	.	PUNCT
bjp-19568	143	5	2009	2009	NUM
bjp-19568	143	6	;	;	PUNCT
bjp-19568	143	7	152	152	NUM
bjp-19568	143	8	:	:	SYM
bjp-19568	143	9	479	479	NUM
bjp-19568	143	10	-	-	SYM
bjp-19568	143	11	96	96	NUM
bjp-19568	143	12	.	.	PUNCT
bjp-19568	144	1	ichikawa	ichikawa	PROPN
bjp-19568	144	2	h	h	PROPN
bjp-19568	144	3	,	,	PUNCT
bjp-19568	144	4	takada	takada	PROPN
bjp-19568	144	5	y	y	PROPN
bjp-19568	144	6	,	,	PUNCT
bjp-19568	144	7	shishodia	shishodia	PROPN
bjp-19568	144	8	s	s	PART
bjp-19568	144	9	,	,	PUNCT
bjp-19568	144	10	jayaprakasam	jayaprakasam	PROPN
bjp-19568	144	11	b	b	PROPN
bjp-19568	144	12	,	,	PUNCT
bjp-19568	144	13	nair	nair	NOUN
bjp-19568	144	14	mg	mg	PROPN
bjp-19568	144	15	,	,	PUNCT
bjp-19568	144	16	aggarwal	aggarwal	PROPN
bjp-19568	144	17	bb	bb	PROPN
bjp-19568	144	18	.	.	PROPN
bjp-19568	145	1	withanolides	withanolide	NOUN
bjp-19568	145	2	potentiate	potentiate	VERB
bjp-19568	145	3	apoptosis	apoptosis	NOUN
bjp-19568	145	4	,	,	PUNCT
bjp-19568	145	5	inhibit	inhibit	NOUN
bjp-19568	145	6	invasion	invasion	NOUN
bjp-19568	145	7	,	,	PUNCT
bjp-19568	145	8	and	and	CCONJ
bjp-19568	145	9	abolish	abolish	VERB
bjp-19568	145	10	osteoclastogenesis	osteoclastogenesis	NOUN
bjp-19568	145	11	through	through	ADP
bjp-19568	145	12	suppression	suppression	NOUN
bjp-19568	145	13	of	of	ADP
bjp-19568	145	14	nuclear	nuclear	ADJ
bjp-19568	145	15	factor	factor	NOUN
bjp-19568	145	16	-	-	PUNCT
bjp-19568	145	17	kappab	kappab	NOUN
bjp-19568	145	18	(	(	PUNCT
bjp-19568	145	19	nf	nf	NOUN
bjp-19568	145	20	-	-	PUNCT
bjp-19568	145	21	jb	jb	NOUN
bjp-19568	145	22	)	)	PUNCT
bjp-19568	145	23	activation	activation	NOUN
bjp-19568	145	24	and	and	CCONJ
bjp-19568	145	25	nf	nf	NOUN
bjp-19568	145	26	-	-	PUNCT
bjp-19568	145	27	jb	jb	NOUN
bjp-19568	145	28	-	-	PUNCT
bjp-19568	145	29	regulated	regulate	VERB
bjp-19568	145	30	gene	gene	NOUN
bjp-19568	145	31	expression	expression	NOUN
bjp-19568	145	32	.	.	PUNCT
bjp-19568	146	1	mol	mol	ADP
bjp-19568	146	2	cancer	cancer	NOUN
bjp-19568	146	3	ther	ther	ADV
bjp-19568	146	4	.	.	PUNCT
bjp-19568	147	1	2006	2006	NUM
bjp-19568	147	2	;	;	PUNCT
bjp-19568	147	3	5	5	NUM
bjp-19568	147	4	:	:	SYM
bjp-19568	147	5	1434	1434	NUM
bjp-19568	147	6	-	-	SYM
bjp-19568	147	7	45	45	NUM
bjp-19568	147	8	.	.	PUNCT
bjp-19568	148	1	jang	jang	PROPN
bjp-19568	148	2	ms	ms	PROPN
bjp-19568	148	3	,	,	PUNCT
bjp-19568	148	4	miao	miao	PROPN
bjp-19568	148	5	h	h	PROPN
bjp-19568	148	6	,	,	PUNCT
bjp-19568	148	7	carlesso	carlesso	PROPN
bjp-19568	148	8	n	n	CCONJ
bjp-19568	148	9	,	,	PUNCT
bjp-19568	148	10	shelly	shelly	PROPN
bjp-19568	148	11	l	l	PROPN
bjp-19568	148	12	,	,	PUNCT
bjp-19568	148	13	zlobin	zlobin	PROPN
bjp-19568	148	14	a	a	PRON
bjp-19568	148	15	,	,	PUNCT
bjp-19568	148	16	darack	darack	NOUN
bjp-19568	148	17	n	n	INTJ
bjp-19568	148	18	et	et	NOUN
bjp-19568	148	19	al.notch-1	al.notch-1	PROPN
bjp-19568	148	20	regulates	regulate	VERB
bjp-19568	148	21	cell	cell	NOUN
bjp-19568	148	22	death	death	NOUN
bjp-19568	148	23	independently	independently	ADV
bjp-19568	148	24	of	of	ADP
bjp-19568	148	25	differentiation	differentiation	NOUN
bjp-19568	148	26	in	in	ADP
bjp-19568	148	27	murine	murine	ADJ
bjp-19568	148	28	erythroleukemia	erythroleukemia	NOUN
bjp-19568	148	29	cells	cell	NOUN
bjp-19568	148	30	through	through	ADP
bjp-19568	148	31	multiple	multiple	ADJ
bjp-19568	148	32	apoptosis	apoptosis	NOUN
bjp-19568	148	33	and	and	CCONJ
bjp-19568	148	34	cell	cell	NOUN
bjp-19568	148	35	cycle	cycle	NOUN
bjp-19568	148	36	pathways	pathway	NOUN
bjp-19568	148	37	.	.	PUNCT
bjp-19568	149	1	j	j	PROPN
bjp-19568	149	2	cell	cell	NOUN
bjp-19568	149	3	physiol	physiol	PROPN
bjp-19568	149	4	.	.	PUNCT
bjp-19568	150	1	2004	2004	NUM
bjp-19568	150	2	;	;	PUNCT
bjp-19568	150	3	199	199	NUM
bjp-19568	150	4	:	:	PUNCT
bjp-19568	150	5	418	418	NUM
bjp-19568	150	6	-	-	SYM
bjp-19568	150	7	33	33	NUM
bjp-19568	150	8	.	.	PUNCT
bjp-19568	151	1	jayaprakasam	jayaprakasam	PROPN
bjp-19568	151	2	b	b	PROPN
bjp-19568	151	3	,	,	PUNCT
bjp-19568	151	4	nair	nair	NOUN
bjp-19568	151	5	mg	mg	PROPN
bjp-19568	151	6	.	.	PUNCT
bjp-19568	152	1	cyclooxygenase-2	cyclooxygenase-2	PRON
bjp-19568	152	2	enzyme	enzyme	VERB
bjp-19568	152	3	inhibitory	inhibitory	ADJ
bjp-19568	152	4	withanolides	withanolide	NOUN
bjp-19568	152	5	from	from	ADP
bjp-19568	152	6	withania	withania	PROPN
bjp-19568	152	7	somnifera	somnifera	PROPN
bjp-19568	152	8	leaves	leave	VERB
bjp-19568	152	9	.	.	PUNCT
bjp-19568	153	1	tetrahedron	tetrahedron	NOUN
bjp-19568	153	2	2003	2003	NUM
bjp-19568	153	3	;	;	PUNCT
bjp-19568	153	4	59	59	NUM
bjp-19568	153	5	:	:	PUNCT
bjp-19568	153	6	841	841	NUM
bjp-19568	153	7	-	-	SYM
bjp-19568	153	8	49	49	NUM
bjp-19568	153	9	.	.	PUNCT
bjp-19568	154	1	kaileh	kaileh	PROPN
bjp-19568	154	2	m	m	PROPN
bjp-19568	154	3	,	,	PUNCT
bjp-19568	154	4	berghe	berghe	PROPN
bjp-19568	154	5	wv	wv	PROPN
bjp-19568	154	6	,	,	PUNCT
bjp-19568	154	7	heyerick	heyerick	PROPN
bjp-19568	154	8	a	a	PRON
bjp-19568	154	9	,	,	PUNCT
bjp-19568	154	10	horion	horion	PROPN
bjp-19568	154	11	j	j	PROPN
bjp-19568	154	12	,	,	PUNCT
bjp-19568	154	13	piette	piette	PROPN
bjp-19568	154	14	j	j	PROPN
bjp-19568	154	15	,	,	PUNCT
bjp-19568	154	16	libert	libert	PROPN
bjp-19568	154	17	c	c	PROPN
bjp-19568	154	18	,	,	PUNCT
bjp-19568	154	19	et	et	PROPN
bjp-19568	154	20	al	al	PROPN
bjp-19568	154	21	.	.	PROPN
bjp-19568	154	22	withaferin	withaferin	PROPN
bjp-19568	154	23	a	a	DET
bjp-19568	154	24	strongly	strongly	ADV
bjp-19568	154	25	elicits	elicit	VERB
bjp-19568	154	26	ikappab	ikappab	NOUN
bjp-19568	154	27	kinase	kinase	PROPN
bjp-19568	154	28	beta	beta	ADJ
bjp-19568	154	29	hyperphosphorylation	hyperphosphorylation	NOUN
bjp-19568	154	30	concomitant	concomitant	ADJ
bjp-19568	154	31	with	with	ADP
bjp-19568	154	32	potent	potent	ADJ
bjp-19568	154	33	inhibition	inhibition	NOUN
bjp-19568	154	34	of	of	ADP
bjp-19568	154	35	its	its	PRON
bjp-19568	154	36	kinase	kinase	NOUN
bjp-19568	154	37	activity	activity	NOUN
bjp-19568	154	38	.	.	PUNCT
bjp-19568	155	1	j	j	PROPN
bjp-19568	155	2	biol	biol	PROPN
bjp-19568	155	3	chem	chem	NOUN
bjp-19568	155	4	.	.	PUNCT
bjp-19568	156	1	2007	2007	NUM
bjp-19568	156	2	;	;	PUNCT
bjp-19568	156	3	282	282	NUM
bjp-19568	156	4	:	:	SYM
bjp-19568	156	5	4253	4253	NUM
bjp-19568	156	6	-	-	SYM
bjp-19568	156	7	64	64	NUM
bjp-19568	156	8	.	.	PUNCT
bjp-19568	157	1	katoh	katoh	NOUN
bjp-19568	157	2	m.	m.	NOUN
bjp-19568	157	3	notch	notch	NOUN
bjp-19568	157	4	signaling	signal	VERB
bjp-19568	157	5	in	in	ADP
bjp-19568	157	6	gastrointestinal	gastrointestinal	ADJ
bjp-19568	157	7	tract	tract	NOUN
bjp-19568	157	8	(	(	PUNCT
bjp-19568	157	9	review	review	NOUN
bjp-19568	157	10	)	)	PUNCT
bjp-19568	157	11	.	.	PUNCT
bjp-19568	158	1	int	int	NOUN
bjp-19568	158	2	j	j	PROPN
bjp-19568	158	3	oncol	oncol	ADJ
bjp-19568	158	4	2007	2007	NUM
bjp-19568	158	5	;	;	PUNCT
bjp-19568	158	6	30	30	NUM
bjp-19568	158	7	:	:	SYM
bjp-19568	158	8	247	247	NUM
bjp-19568	158	9	-	-	SYM
bjp-19568	158	10	51	51	NUM
bjp-19568	158	11	leong	leong	PROPN
bjp-19568	158	12	kg	kg	PROPN
bjp-19568	158	13	,	,	PUNCT
bjp-19568	158	14	karsan	karsan	ADJ
bjp-19568	158	15	a.	a.	NOUN
bjp-19568	158	16	recent	recent	ADJ
bjp-19568	158	17	insights	insight	NOUN
bjp-19568	158	18	into	into	ADP
bjp-19568	158	19	the	the	DET
bjp-19568	158	20	role	role	NOUN
bjp-19568	158	21	of	of	ADP
bjp-19568	158	22	notch	notch	NOUN
bjp-19568	158	23	signaling	signal	VERB
bjp-19568	158	24	in	in	ADP
bjp-19568	158	25	tumorigenesis	tumorigenesis	NOUN
bjp-19568	158	26	.	.	PUNCT
bjp-19568	159	1	blood	blood	NOUN
bjp-19568	159	2	2006	2006	NUM
bjp-19568	159	3	;	;	PUNCT
bjp-19568	159	4	107	107	NUM
bjp-19568	159	5	:	:	PUNCT
bjp-19568	159	6	2223	2223	NUM
bjp-19568	159	7	-	-	SYM
bjp-19568	159	8	33	33	NUM
bjp-19568	159	9	.	.	PUNCT
bjp-19568	160	1	koduru	koduru	PROPN
bjp-19568	160	2	s	s	PROPN
bjp-19568	160	3	,	,	PUNCT
bjp-19568	160	4	kumar	kumar	PROPN
bjp-19568	160	5	r	r	PROPN
bjp-19568	160	6	,	,	PUNCT
bjp-19568	160	7	srinivasan	srinivasan	NOUN
bjp-19568	160	8	s	s	PROPN
bjp-19568	160	9	,	,	PUNCT
bjp-19568	160	10	evers	ever	NOUN
bjp-19568	160	11	mb	mb	VERB
bjp-19568	160	12	,	,	PUNCT
bjp-19568	160	13	damodaran	damodaran	VERB
bjp-19568	160	14	c.	c.	PROPN
bjp-19568	160	15	notch-1	notch-1	PROPN
bjp-19568	160	16	inhibition	inhibition	NOUN
bjp-19568	160	17	by	by	ADP
bjp-19568	160	18	withaferin	withaferin	NOUN
bjp-19568	160	19	-	-	PUNCT
bjp-19568	160	20	a	a	NOUN
bjp-19568	160	21	:	:	PUNCT
bjp-19568	160	22	a	a	DET
bjp-19568	160	23	therapeutic	therapeutic	ADJ
bjp-19568	160	24	target	target	NOUN
bjp-19568	160	25	against	against	ADP
bjp-19568	160	26	colon	colon	NOUN
bjp-19568	160	27	carcinogenesis	carcinogenesis	NOUN
bjp-19568	160	28	.	.	PUNCT
bjp-19568	161	1	mol	mol	ADP
bjp-19568	161	2	cancer	cancer	NOUN
bjp-19568	161	3	ther	ther	ADV
bjp-19568	161	4	.	.	PUNCT
bjp-19568	162	1	2010	2010	NUM
bjp-19568	162	2	;	;	PUNCT
bjp-19568	162	3	9	9	NUM
bjp-19568	162	4	:	:	SYM
bjp-19568	162	5	20210	20210	NUM
bjp-19568	162	6	.	.	PUNCT
bjp-19568	163	1	li	li	PROPN
bjp-19568	163	2	jl	jl	PROPN
bjp-19568	163	3	,	,	PUNCT
bjp-19568	163	4	harris	harris	PROPN
bjp-19568	163	5	al	al	PROPN
bjp-19568	163	6	.	.	PROPN
bjp-19568	163	7	notch	notch	PROPN
bjp-19568	163	8	signaling	signal	VERB
bjp-19568	163	9	from	from	ADP
bjp-19568	163	10	tumor	tumor	NOUN
bjp-19568	163	11	cells	cell	NOUN
bjp-19568	163	12	:	:	PUNCT
bjp-19568	163	13	a	a	DET
bjp-19568	163	14	new	new	ADJ
bjp-19568	163	15	mechanism	mechanism	NOUN
bjp-19568	163	16	of	of	ADP
bjp-19568	163	17	angiogenesis	angiogenesis	NOUN
bjp-19568	163	18	.	.	PUNCT
bjp-19568	164	1	cancer	cancer	NOUN
bjp-19568	164	2	cell	cell	NOUN
bjp-19568	164	3	.	.	PUNCT
bjp-19568	165	1	2005	2005	NUM
bjp-19568	165	2	;	;	PUNCT
bjp-19568	165	3	8	8	NUM
bjp-19568	165	4	:	:	SYM
bjp-19568	165	5	1	1	NUM
bjp-19568	165	6	-	-	SYM
bjp-19568	165	7	3	3	NUM
bjp-19568	165	8	.	.	X
bjp-19568	166	1	petrilli	petrilli	PROPN
bjp-19568	166	2	as	as	ADP
bjp-19568	166	3	,	,	PUNCT
bjp-19568	166	4	de	de	PROPN
bjp-19568	166	5	camargo	camargo	PROPN
bjp-19568	166	6	b	b	PROPN
bjp-19568	166	7	,	,	PUNCT
bjp-19568	166	8	filho	filho	PROPN
bjp-19568	166	9	vo	vo	NOUN
bjp-19568	166	10	,	,	PUNCT
bjp-19568	166	11	bruniera	bruniera	NOUN
bjp-19568	166	12	p	p	NOUN
bjp-19568	166	13	,	,	PUNCT
bjp-19568	166	14	brunetto	brunetto	NOUN
bjp-19568	166	15	al	al	PROPN
bjp-19568	166	16	,	,	PUNCT
bjp-19568	166	17	jesus	jesus	PROPN
bjp-19568	166	18	-	-	PUNCT
bjp-19568	166	19	garcia	garcia	PROPN
bjp-19568	166	20	r	r	PROPN
bjp-19568	166	21	,	,	PUNCT
bjp-19568	167	1	et	et	PROPN
bjp-19568	167	2	al	al	PROPN
bjp-19568	167	3	.	.	PROPN
bjp-19568	167	4	results	result	NOUN
bjp-19568	167	5	of	of	ADP
bjp-19568	167	6	the	the	DET
bjp-19568	167	7	brazilian	brazilian	ADJ
bjp-19568	167	8	osteosarcoma	osteosarcoma	ADJ
bjp-19568	167	9	treatment	treatment	NOUN
bjp-19568	167	10	group	group	NOUN
bjp-19568	167	11	studies	study	NOUN
bjp-19568	167	12	iii	iii	PROPN
bjp-19568	167	13	and	and	CCONJ
bjp-19568	167	14	iv	iv	NUM
bjp-19568	167	15	:	:	PUNCT
bjp-19568	167	16	prognostic	prognostic	ADJ
bjp-19568	167	17	factors	factor	NOUN
bjp-19568	167	18	and	and	CCONJ
bjp-19568	167	19	impact	impact	NOUN
bjp-19568	167	20	on	on	ADP
bjp-19568	167	21	survival	survival	NOUN
bjp-19568	167	22	.	.	PUNCT
bjp-19568	168	1	j	j	PROPN
bjp-19568	168	2	clin	clin	PROPN
bjp-19568	168	3	oncol	oncol	PROPN
bjp-19568	168	4	.	.	PUNCT
bjp-19568	169	1	2006	2006	NUM
bjp-19568	169	2	;	;	PUNCT
bjp-19568	169	3	24	24	NUM
bjp-19568	169	4	:	:	SYM
bjp-19568	169	5	1161	1161	NUM
bjp-19568	169	6	-	-	SYM
bjp-19568	169	7	68	68	NUM
bjp-19568	169	8	ramdass	ramdass	NOUN
bjp-19568	169	9	b	b	NOUN
bjp-19568	169	10	,	,	PUNCT
bjp-19568	169	11	maliekal	maliekal	PROPN
bjp-19568	169	12	tt	tt	PROPN
bjp-19568	169	13	,	,	PUNCT
bjp-19568	169	14	lakshmi	lakshmi	NOUN
bjp-19568	169	15	s	s	PART
bjp-19568	169	16	,	,	PUNCT
bjp-19568	169	17	rehman	rehman	PROPN
bjp-19568	169	18	m	m	PROPN
bjp-19568	169	19	,	,	PUNCT
bjp-19568	169	20	rema	rema	PROPN
bjp-19568	169	21	p	p	NOUN
bjp-19568	169	22	,	,	PUNCT
bjp-19568	169	23	nair	nair	NOUN
bjp-19568	169	24	p	p	NOUN
bjp-19568	169	25	,	,	PUNCT
bjp-19568	169	26	et	et	PROPN
bjp-19568	169	27	al	al	PROPN
bjp-19568	169	28	.	.	PUNCT
bjp-19568	169	29	coexpression	coexpression	NOUN
bjp-19568	169	30	of	of	ADP
bjp-19568	169	31	notch1	notch1	NOUN
bjp-19568	169	32	and	and	CCONJ
bjp-19568	169	33	nf	nf	ADJ
bjp-19568	169	34	-	-	PUNCT
bjp-19568	169	35	kappab	kappab	NOUN
bjp-19568	169	36	signaling	signal	VERB
bjp-19568	169	37	pathway	pathway	NOUN
bjp-19568	169	38	components	component	NOUN
bjp-19568	169	39	in	in	ADP
bjp-19568	169	40	human	human	ADJ
bjp-19568	169	41	cervical	cervical	ADJ
bjp-19568	169	42	cancer	cancer	NOUN
bjp-19568	169	43	progression	progression	NOUN
bjp-19568	169	44	.	.	PUNCT
bjp-19568	170	1	gynecol	gynecol	ADJ
bjp-19568	170	2	oncol	oncol	ADJ
bjp-19568	170	3	.	.	PUNCT
bjp-19568	171	1	2007	2007	NUM
bjp-19568	171	2	;	;	PUNCT
bjp-19568	171	3	104	104	NUM
bjp-19568	171	4	:	:	PUNCT
bjp-19568	171	5	352	352	NUM
bjp-19568	171	6	-	-	SYM
bjp-19568	171	7	61	61	NUM
bjp-19568	171	8	.	.	PUNCT
bjp-19568	172	1	srinivasan	srinivasan	PROPN
bjp-19568	172	2	s	s	PROPN
bjp-19568	172	3	,	,	PUNCT
bjp-19568	172	4	ranga	ranga	PROPN
bjp-19568	172	5	rs	rs	NOUN
bjp-19568	172	6	,	,	PUNCT
bjp-19568	172	7	burikhanov	burikhanov	NOUN
bjp-19568	172	8	r	r	NOUN
bjp-19568	172	9	,	,	PUNCT
bjp-19568	172	10	han	han	PROPN
bjp-19568	172	11	ss	ss	PROPN
bjp-19568	172	12	,	,	PUNCT
bjp-19568	172	13	chendil	chendil	PROPN
bjp-19568	172	14	d.	d.	PROPN
bjp-19568	172	15	par4	par4	PROPN
bjp-19568	172	16	-	-	PUNCT
bjp-19568	172	17	dependent	dependent	ADJ
bjp-19568	172	18	apoptosis	apoptosis	NOUN
bjp-19568	172	19	by	by	ADP
bjp-19568	172	20	the	the	DET
bjp-19568	172	21	dietary	dietary	ADJ
bjp-19568	172	22	compound	compound	NOUN
bjp-19568	172	23	withaferin	withaferin	NOUN
bjp-19568	172	24	a	a	PRON
bjp-19568	172	25	in	in	ADP
bjp-19568	172	26	prostate	prostate	NOUN
bjp-19568	172	27	cancer	cancer	NOUN
bjp-19568	172	28	cells	cell	NOUN
bjp-19568	172	29	.	.	PUNCT
bjp-19568	173	1	cancer	cancer	NOUN
bjp-19568	173	2	res	re	NOUN
bjp-19568	173	3	.	.	PUNCT
bjp-19568	173	4	2007	2007	NUM
bjp-19568	173	5	;	;	PUNCT
bjp-19568	173	6	67	67	NUM
bjp-19568	173	7	:	:	SYM
bjp-19568	173	8	246	246	NUM
bjp-19568	173	9	-	-	SYM
bjp-19568	173	10	53	53	NUM
bjp-19568	173	11	.	.	PUNCT
bjp-19568	174	1	stan	stan	PROPN
bjp-19568	174	2	sd	sd	PROPN
bjp-19568	174	3	,	,	PUNCT
bjp-19568	174	4	hahm	hahm	PROPN
bjp-19568	174	5	er	er	INTJ
bjp-19568	174	6	,	,	PUNCT
bjp-19568	174	7	warin	warin	PROPN
bjp-19568	174	8	r	r	PROPN
bjp-19568	174	9	,	,	PUNCT
bjp-19568	174	10	singh	singh	PROPN
bjp-19568	174	11	sv	sv	PROPN
bjp-19568	174	12	.	.	PROPN
bjp-19568	174	13	withaferin	withaferin	PROPN
bjp-19568	174	14	a	a	DET
bjp-19568	174	15	causes	cause	NOUN
bjp-19568	174	16	foxo3aand	foxo3aand	NOUN
bjp-19568	174	17	bim	bim	NOUN
bjp-19568	174	18	-	-	PUNCT
bjp-19568	174	19	dependent	dependent	ADJ
bjp-19568	174	20	apoptosis	apoptosis	NOUN
bjp-19568	174	21	and	and	CCONJ
bjp-19568	174	22	inhibits	inhibit	VERB
bjp-19568	174	23	growth	growth	NOUN
bjp-19568	174	24	of	of	ADP
bjp-19568	174	25	human	human	ADJ
bjp-19568	174	26	breast	breast	NOUN
bjp-19568	174	27	cancer	cancer	NOUN
bjp-19568	174	28	cells	cell	NOUN
bjp-19568	174	29	in	in	ADP
bjp-19568	174	30	vivo	vivo	NOUN
bjp-19568	174	31	.	.	PUNCT
bjp-19568	175	1	cancer	cancer	NOUN
bjp-19568	175	2	res	re	NOUN
bjp-19568	175	3	.	.	PUNCT
bjp-19568	175	4	2008	2008	NUM
bjp-19568	175	5	;	;	PUNCT
bjp-19568	175	6	68	68	NUM
bjp-19568	175	7	:	:	PUNCT
bjp-19568	175	8	7661	7661	NUM
bjp-19568	175	9	-	-	SYM
bjp-19568	175	10	69	69	NUM
bjp-19568	175	11	.	.	PUNCT
bjp-19568	176	1	subbaraju	subbaraju	PROPN
bjp-19568	176	2	gv	gv	ADP
bjp-19568	176	3	,	,	PUNCT
bjp-19568	176	4	vanisree	vanisree	PROPN
bjp-19568	176	5	m	m	PROPN
bjp-19568	176	6	,	,	PUNCT
bjp-19568	176	7	rao	rao	PROPN
bjp-19568	176	8	cv	cv	PROPN
bjp-19568	176	9	,	,	PUNCT
bjp-19568	176	10	sivaramakrishna	sivaramakrishna	ADJ
bjp-19568	176	11	c	c	NOUN
bjp-19568	176	12	,	,	PUNCT
bjp-19568	176	13	sridhar	sridhar	VERB
bjp-19568	176	14	p	p	NOUN
bjp-19568	176	15	,	,	PUNCT
bjp-19568	176	16	jayaprakasam	jayaprakasam	PROPN
bjp-19568	176	17	b	b	PROPN
bjp-19568	176	18	,	,	PUNCT
bjp-19568	176	19	et	et	PROPN
bjp-19568	176	20	al	al	PROPN
bjp-19568	176	21	.	.	PROPN
bjp-19568	177	1	ashwagandhanolide	ashwagandhanolide	PROPN
bjp-19568	177	2	,	,	PUNCT
bjp-19568	177	3	a	a	DET
bjp-19568	177	4	bioactive	bioactive	ADJ
bjp-19568	177	5	dimeric	dimeric	ADJ
bjp-19568	177	6	thiowithanolide	thiowithanolide	NOUN
bjp-19568	177	7	isolated	isolate	VERB
bjp-19568	177	8	from	from	ADP
bjp-19568	177	9	the	the	DET
bjp-19568	177	10	roots	root	NOUN
bjp-19568	177	11	of	of	ADP
bjp-19568	177	12	withania	withania	PROPN
bjp-19568	177	13	somnifera	somnifera	PROPN
bjp-19568	177	14	.	.	PUNCT
bjp-19568	178	1	j	j	PROPN
bjp-19568	178	2	nat	nat	PROPN
bjp-19568	178	3	prod	prod	NOUN
bjp-19568	178	4	.	.	PUNCT
bjp-19568	179	1	2006	2006	NUM
bjp-19568	179	2	;	;	PUNCT
bjp-19568	179	3	69	69	NUM
bjp-19568	179	4	:	:	SYM
bjp-19568	179	5	1790	1790	NUM
bjp-19568	179	6	-	-	SYM
bjp-19568	179	7	92	92	NUM
bjp-19568	179	8	.	.	PUNCT
bjp-19568	180	1	tanaka	tanaka	PROPN
bjp-19568	180	2	m	m	PROPN
bjp-19568	180	3	,	,	PUNCT
bjp-19568	180	4	setoguchi	setoguchi	PROPN
bjp-19568	180	5	t	t	PROPN
bjp-19568	180	6	,	,	PUNCT
bjp-19568	180	7	hirotsu	hirotsu	NOUN
bjp-19568	180	8	m	m	PROPN
bjp-19568	180	9	,	,	PUNCT
bjp-19568	180	10	gao	gao	PROPN
bjp-19568	180	11	h	h	PROPN
bjp-19568	180	12	,	,	PUNCT
bjp-19568	180	13	sasaki	sasaki	PROPN
bjp-19568	180	14	h	h	PROPN
bjp-19568	180	15	,	,	PUNCT
bjp-19568	180	16	matsunoshita	matsunoshita	PROPN
bjp-19568	180	17	y	y	PROPN
bjp-19568	180	18	,	,	PUNCT
bjp-19568	180	19	et	et	PROPN
bjp-19568	180	20	al	al	PROPN
bjp-19568	180	21	.	.	PROPN
bjp-19568	180	22	inhibition	inhibition	NOUN
bjp-19568	180	23	of	of	ADP
bjp-19568	180	24	notch	notch	ADJ
bjp-19568	180	25	pathway	pathway	NOUN
bjp-19568	180	26	prevents	prevent	VERB
bjp-19568	180	27	osteosarcoma	osteosarcoma	ADJ
bjp-19568	180	28	growth	growth	NOUN
bjp-19568	180	29	by	by	ADP
bjp-19568	180	30	cell	cell	NOUN
bjp-19568	180	31	cycle	cycle	NOUN
bjp-19568	180	32	regulation	regulation	NOUN
bjp-19568	180	33	.	.	PUNCT
bjp-19568	181	1	br	br	PROPN
bjp-19568	181	2	j	j	PROPN
bjp-19568	181	3	cancer	cancer	PROPN
bjp-19568	181	4	2009	2009	NUM
bjp-19568	181	5	;	;	PUNCT
bjp-19568	181	6	100	100	NUM
bjp-19568	181	7	:	:	SYM
bjp-19568	181	8	1957	1957	NUM
bjp-19568	181	9	-	-	SYM
bjp-19568	181	10	65	65	NUM
bjp-19568	181	11	.	.	PUNCT
bjp-19568	182	1	wang	wang	PROPN
bjp-19568	182	2	z	z	PROPN
bjp-19568	182	3	,	,	PUNCT
bjp-19568	182	4	zhang	zhang	PROPN
bjp-19568	182	5	y	y	PROPN
bjp-19568	182	6	,	,	PUNCT
bjp-19568	182	7	li	li	PROPN
bjp-19568	182	8	y	y	PROPN
bjp-19568	182	9	,	,	PUNCT
bjp-19568	182	10	banerjee	banerjee	PROPN
bjp-19568	182	11	s	s	PROPN
bjp-19568	182	12	,	,	PUNCT
bjp-19568	182	13	liao	liao	PROPN
bjp-19568	182	14	j	j	PROPN
bjp-19568	182	15	,	,	PUNCT
bjp-19568	182	16	sarkar	sarkar	PROPN
bjp-19568	182	17	fh	fh	PROPN
bjp-19568	182	18	.	.	PUNCT
bjp-19568	183	1	downregulation	downregulation	NOUN
bjp-19568	183	2	of	of	ADP
bjp-19568	183	3	notch-1	notch-1	PRON
bjp-19568	183	4	contributes	contribute	VERB
bjp-19568	183	5	to	to	ADP
bjp-19568	183	6	cell	cell	NOUN
bjp-19568	183	7	growth	growth	NOUN
bjp-19568	183	8	inhibition	inhibition	NOUN
bjp-19568	183	9	and	and	CCONJ
bjp-19568	183	10	apoptosis	apoptosis	NOUN
bjp-19568	183	11	in	in	ADP
bjp-19568	183	12	pancreatic	pancreatic	ADJ
bjp-19568	183	13	cancer	cancer	NOUN
bjp-19568	183	14	cells	cell	NOUN
bjp-19568	183	15	.	.	PUNCT
bjp-19568	184	1	mol	mol	ADP
bjp-19568	184	2	cancer	cancer	NOUN
bjp-19568	184	3	ther	ther	ADV
bjp-19568	184	4	.	.	PUNCT
bjp-19568	185	1	2006	2006	NUM
bjp-19568	185	2	;	;	PUNCT
bjp-19568	185	3	5	5	NUM
bjp-19568	185	4	:	:	SYM
bjp-19568	185	5	483	483	NUM
bjp-19568	185	6	-	-	SYM
bjp-19568	185	7	93	93	NUM
bjp-19568	185	8	.	.	PUNCT
bjp-19568	186	1	zhang	zhang	PROPN
bjp-19568	186	2	p	p	PROPN
bjp-19568	186	3	,	,	PUNCT
bjp-19568	186	4	yang	yang	PROPN
bjp-19568	186	5	y	y	PROPN
bjp-19568	186	6	,	,	PUNCT
bjp-19568	186	7	zweidler	zweidler	PROPN
bjp-19568	186	8	-	-	PUNCT
bjp-19568	186	9	mckay	mckay	PROPN
bjp-19568	186	10	pa	pa	PROPN
bjp-19568	186	11	,	,	PUNCT
bjp-19568	186	12	hughes	hughes	PROPN
bjp-19568	186	13	dp	dp	PROPN
bjp-19568	186	14	.	.	PUNCT
bjp-19568	186	15	critical	critical	ADJ
bjp-19568	186	16	role	role	NOUN
bjp-19568	186	17	of	of	ADP
bjp-19568	186	18	notch	notch	NOUN
bjp-19568	186	19	signaling	signal	VERB
bjp-19568	186	20	in	in	ADP
bjp-19568	186	21	osteosarcoma	osteosarcoma	ADJ
bjp-19568	186	22	invasion	invasion	NOUN
bjp-19568	186	23	and	and	CCONJ
bjp-19568	186	24	metastasis	metastasis	NOUN
bjp-19568	186	25	.	.	PUNCT
bjp-19568	187	1	clin	clin	PROPN
bjp-19568	187	2	cancer	cancer	NOUN
bjp-19568	187	3	res	re	NOUN
bjp-19568	187	4	.	.	PUNCT
bjp-19568	187	5	2008	2008	NUM
bjp-19568	187	6	;	;	PUNCT
bjp-19568	187	7	14	14	NUM
bjp-19568	187	8	:	:	SYM
bjp-19568	187	9	2962	2962	NUM
bjp-19568	187	10	-	-	SYM
bjp-19568	187	11	69	69	NUM
bjp-19568	187	12	.	.	PUNCT
bjp-19568	188	1	370	370	NUM
bjp-19568	188	2	bangladesh	bangladesh	PROPN
bjp-19568	188	3	j	j	PROPN
bjp-19568	188	4	pharmacol	pharmacol	PROPN
bjp-19568	188	5	2014	2014	NUM
bjp-19568	188	6	;	;	PUNCT
bjp-19568	188	7	9	9	NUM
bjp-19568	188	8	:	:	SYM
bjp-19568	188	9	364	364	NUM
bjp-19568	188	10	-	-	SYM
bjp-19568	188	11	370	370	NUM
bjp-19568	188	12	author	author	NOUN
bjp-19568	188	13	info	info	NOUN
bjp-19568	188	14	xiao	xiao	PROPN
bjp-19568	188	15	li	li	PROPN
bjp-19568	188	16	(	(	PUNCT
bjp-19568	188	17	principal	principal	ADJ
bjp-19568	188	18	contact	contact	NOUN
bjp-19568	188	19	)	)	PUNCT
bjp-19568	189	1	e	e	NOUN
bjp-19568	189	2	-	-	NOUN
bjp-19568	189	3	mail	mail	NOUN
bjp-19568	189	4	:	:	PUNCT
bjp-19568	189	5	lixiao2765@gmail.com	lixiao2765@gmail.com	X
bjp-19568	190	1	osteosarcoma	osteosarcoma	ADJ
bjp-19568	190	2	cells	cell	NOUN
bjp-19568	190	3	to	to	ADP
bjp-19568	190	4	standard	standard	ADJ
bjp-19568	190	5	therapeutics	therapeutic	NOUN
bjp-19568	190	6	:	:	PUNCT
bjp-19568	190	7	author	author	NOUN
bjp-19568	190	8	info	info	PROPN
bjp-19568	190	9	xiao	xiao	PROPN
bjp-19568	190	10	li	li	PROPN
bjp-19568	190	11	principal	principal	PROPN
bjp-19568	190	12	contact	contact	NOUN
bjp-19568	190	13	email	email	NOUN
bjp-19568	190	14	lixiao2765gmailcom	lixiao2765gmailcom	PROPN
bjp-19568	190	15	:	:	PUNCT
bjp-19568	190	16	dateprinted	dateprinte	VERB
bjp-19568	190	17	:	:	PUNCT
bjp-19568	190	18	this	this	DET
bjp-19568	190	19	article	article	NOUN
bjp-19568	190	20	was	be	AUX
bjp-19568	190	21	downloaded	download	VERB
bjp-19568	190	22	by	by	ADP
bjp-19568	190	23	you	you	PRON
bjp-19568	190	24	on	on	ADP
bjp-19568	190	25	:	:	PUNCT
bjp-19568	190	26	jul	jul	PROPN
bjp-19568	190	27	27	27	NUM
bjp-19568	190	28	,	,	PUNCT
bjp-19568	190	29	2018	2018	NUM