id	sid	tid	token	lemma	pos
bjp-20418	1	1	bangladesh	bangladesh	PROPN
bjp-20418	1	2	journal	journal	PROPN
bjp-20418	1	3	of	of	ADP
bjp-20418	1	4	pharmacology	pharmacology	NOUN
bjp-20418	1	5	research	research	NOUN
bjp-20418	1	6	article	article	NOUN
bjp-20418	1	7	role	role	NOUN
bjp-20418	1	8	of	of	ADP
bjp-20418	1	9	smad	smad	PROPN
bjp-20418	1	10	signaling	signal	VERB
bjp-20418	1	11	in	in	ADP
bjp-20418	1	12	druginduced	druginduced	ADJ
bjp-20418	1	13	apoptosis	apoptosis	NOUN
bjp-20418	1	14	in	in	ADP
bjp-20418	1	15	colon	colon	NOUN
bjp-20418	1	16	cancer	cancer	NOUN
bjp-20418	1	17	bjp	bjp	PROPN
bjp-20418	1	18	introduction	introduction	NOUN
bjp-20418	1	19	smad	smad	PROPN
bjp-20418	1	20	family	family	NOUN
bjp-20418	1	21	of	of	ADP
bjp-20418	1	22	proteins	protein	NOUN
bjp-20418	1	23	is	be	AUX
bjp-20418	1	24	implicated	implicate	VERB
bjp-20418	1	25	in	in	ADP
bjp-20418	1	26	tgf	tgf	PROPN
bjp-20418	1	27	-	-	PUNCT
bjp-20418	1	28	β	β	PROPN
bjp-20418	1	29	signaling	signal	VERB
bjp-20418	1	30	mediated	mediate	VERB
bjp-20418	1	31	epithelial	epithelial	ADJ
bjp-20418	1	32	growth	growth	NOUN
bjp-20418	1	33	inhibition	inhibition	NOUN
bjp-20418	1	34	(	(	PUNCT
bjp-20418	1	35	massague	massague	NOUN
bjp-20418	1	36	et	et	PROPN
bjp-20418	1	37	al	al	PROPN
bjp-20418	1	38	.	.	PROPN
bjp-20418	1	39	,	,	PUNCT
bjp-20418	1	40	2008	2008	NUM
bjp-20418	1	41	)	)	PUNCT
bjp-20418	1	42	.	.	PUNCT
bjp-20418	2	1	upon	upon	SCONJ
bjp-20418	2	2	ligand	ligand	NOUN
bjp-20418	2	3	binding	bind	VERB
bjp-20418	2	4	to	to	ADP
bjp-20418	2	5	tgf	tgf	PROPN
bjp-20418	2	6	-	-	PUNCT
bjp-20418	2	7	β	β	NOUN
bjp-20418	2	8	receptors	receptor	NOUN
bjp-20418	2	9	(	(	PUNCT
bjp-20418	2	10	tgfbri	tgfbri	NOUN
bjp-20418	2	11	and	and	CCONJ
bjp-20418	2	12	ii	ii	NOUN
bjp-20418	2	13	)	)	PUNCT
bjp-20418	2	14	,	,	PUNCT
bjp-20418	2	15	phosphorylation	phosphorylation	NOUN
bjp-20418	2	16	of	of	ADP
bjp-20418	2	17	receptor	receptor	NOUN
bjp-20418	2	18	-	-	PUNCT
bjp-20418	2	19	activated	activate	VERB
bjp-20418	2	20	smads	smad	NOUN
bjp-20418	2	21	(	(	PUNCT
bjp-20418	2	22	r	r	NOUN
bjp-20418	2	23	-	-	PUNCT
bjp-20418	2	24	smads	smad	NOUN
bjp-20418	2	25	)	)	PUNCT
bjp-20418	2	26	,	,	PUNCT
bjp-20418	2	27	smad2	smad2	PROPN
bjp-20418	2	28	and	and	CCONJ
bjp-20418	2	29	smad3	smad3	NOUN
bjp-20418	2	30	,	,	PUNCT
bjp-20418	2	31	occur	occur	VERB
bjp-20418	2	32	,	,	PUNCT
bjp-20418	2	33	which	which	PRON
bjp-20418	2	34	then	then	ADV
bjp-20418	2	35	bind	bind	VERB
bjp-20418	2	36	to	to	ADP
bjp-20418	2	37	the	the	DET
bjp-20418	2	38	common	common	ADJ
bjp-20418	2	39	mediator	mediator	NOUN
bjp-20418	2	40	smad	smad	NOUN
bjp-20418	2	41	(	(	PUNCT
bjp-20418	2	42	co	co	NOUN
bjp-20418	2	43	-	-	NOUN
bjp-20418	2	44	smad	smad	ADJ
bjp-20418	2	45	)	)	PUNCT
bjp-20418	2	46	smad4	smad4	NOUN
bjp-20418	2	47	(	(	PUNCT
bjp-20418	2	48	abdollah	abdollah	PROPN
bjp-20418	2	49	et	et	PROPN
bjp-20418	2	50	al	al	PROPN
bjp-20418	2	51	.	.	PROPN
bjp-20418	2	52	,	,	PUNCT
bjp-20418	2	53	1997	1997	NUM
bjp-20418	2	54	;	;	PUNCT
bjp-20418	2	55	souchelnytskyio	souchelnytskyio	PROPN
bjp-20418	2	56	et	et	PROPN
bjp-20418	2	57	al	al	PROPN
bjp-20418	2	58	.	.	PROPN
bjp-20418	2	59	,	,	PUNCT
bjp-20418	2	60	1997	1997	NUM
bjp-20418	2	61	;	;	PUNCT
bjp-20418	2	62	shi	shi	PROPN
bjp-20418	2	63	et	et	PROPN
bjp-20418	2	64	al	al	PROPN
bjp-20418	2	65	.	.	PROPN
bjp-20418	2	66	,	,	PUNCT
bjp-20418	2	67	1997	1997	NUM
bjp-20418	2	68	;	;	PUNCT
bjp-20418	3	1	chacko	chacko	NOUN
bjp-20418	3	2	et	et	PROPN
bjp-20418	3	3	al	al	PROPN
bjp-20418	3	4	.	.	PROPN
bjp-20418	3	5	,	,	PUNCT
bjp-20418	3	6	2001	2001	NUM
bjp-20418	3	7	and	and	CCONJ
bjp-20418	3	8	2004	2004	NUM
bjp-20418	3	9	)	)	PUNCT
bjp-20418	3	10	.	.	PUNCT
bjp-20418	4	1	the	the	DET
bjp-20418	4	2	resulting	result	VERB
bjp-20418	4	3	complex	complex	NOUN
bjp-20418	4	4	then	then	ADV
bjp-20418	4	5	relocates	relocate	VERB
bjp-20418	4	6	into	into	ADP
bjp-20418	4	7	the	the	DET
bjp-20418	4	8	nucleus	nucleus	NOUN
bjp-20418	4	9	and	and	CCONJ
bjp-20418	4	10	regulates	regulate	VERB
bjp-20418	4	11	the	the	DET
bjp-20418	4	12	expression	expression	NOUN
bjp-20418	4	13	of	of	ADP
bjp-20418	4	14	many	many	ADJ
bjp-20418	4	15	genes	gene	NOUN
bjp-20418	4	16	.	.	PUNCT
bjp-20418	5	1	this	this	DET
bjp-20418	5	2	process	process	NOUN
bjp-20418	5	3	could	could	AUX
bjp-20418	5	4	also	also	ADV
bjp-20418	5	5	be	be	AUX
bjp-20418	5	6	regulated	regulate	VERB
bjp-20418	5	7	by	by	ADP
bjp-20418	5	8	another	another	DET
bjp-20418	5	9	inhibitory	inhibitory	ADJ
bjp-20418	5	10	smad	smad	NOUN
bjp-20418	5	11	,	,	PUNCT
bjp-20418	5	12	smad7	smad7	NOUN
bjp-20418	5	13	.	.	PUNCT
bjp-20418	6	1	mutations	mutation	NOUN
bjp-20418	6	2	causing	cause	VERB
bjp-20418	6	3	aberrations	aberration	NOUN
bjp-20418	6	4	in	in	ADP
bjp-20418	6	5	this	this	DET
bjp-20418	6	6	signaling	signal	VERB
bjp-20418	6	7	process	process	NOUN
bjp-20418	6	8	are	be	AUX
bjp-20418	6	9	common	common	ADJ
bjp-20418	6	10	in	in	ADP
bjp-20418	6	11	human	human	ADJ
bjp-20418	6	12	malignancies	malignancy	NOUN
bjp-20418	6	13	including	include	VERB
bjp-20418	6	14	colorectal	colorectal	ADJ
bjp-20418	6	15	cancer	cancer	NOUN
bjp-20418	6	16	(	(	PUNCT
bjp-20418	6	17	crc	crc	NOUN
bjp-20418	6	18	)	)	PUNCT
bjp-20418	6	19	.	.	PUNCT
bjp-20418	7	1	in	in	ADP
bjp-20418	7	2	sporadic	sporadic	ADJ
bjp-20418	7	3	crcs	crcs	NOUN
bjp-20418	7	4	,	,	PUNCT
bjp-20418	7	5	smad4	smad4	NOUN
bjp-20418	7	6	and	and	CCONJ
bjp-20418	7	7	tgfbr2	tgfbr2	NOUN
bjp-20418	7	8	mutations	mutation	NOUN
bjp-20418	7	9	are	be	AUX
bjp-20418	7	10	associated	associate	VERB
bjp-20418	7	11	with	with	ADP
bjp-20418	7	12	~	~	PUNCT
bjp-20418	7	13	10	10	NUM
bjp-20418	7	14	and	and	CCONJ
bjp-20418	7	15	15	15	NUM
bjp-20418	7	16	%	%	NOUN
bjp-20418	7	17	of	of	ADP
bjp-20418	7	18	patients	patient	NOUN
bjp-20418	7	19	respectively	respectively	ADV
bjp-20418	7	20	(	(	PUNCT
bjp-20418	7	21	fleming	fleme	VERB
bjp-20418	7	22	et	et	PROPN
bjp-20418	7	23	al	al	PROPN
bjp-20418	7	24	.	.	PROPN
bjp-20418	7	25	,	,	PUNCT
bjp-20418	7	26	2013	2013	NUM
bjp-20418	7	27	)	)	PUNCT
bjp-20418	7	28	.	.	PUNCT
bjp-20418	8	1	the	the	DET
bjp-20418	8	2	smad	smad	PROPN
bjp-20418	8	3	proteins	protein	NOUN
bjp-20418	8	4	are	be	AUX
bjp-20418	8	5	highly	highly	ADV
bjp-20418	8	6	homologous	homologous	ADJ
bjp-20418	8	7	with	with	ADP
bjp-20418	8	8	2	2	NUM
bjp-20418	8	9	conserved	conserved	ADJ
bjp-20418	8	10	regions	region	NOUN
bjp-20418	8	11	,	,	PUNCT
bjp-20418	8	12	an	an	DET
bjp-20418	8	13	n	n	ADV
bjp-20418	8	14	-	-	PUNCT
bjp-20418	8	15	terminal	terminal	ADJ
bjp-20418	8	16	mad	mad	ADJ
bjp-20418	8	17	homology	homology	NOUN
bjp-20418	8	18	domain-1	domain-1	X
bjp-20418	8	19	(	(	PUNCT
bjp-20418	8	20	mh1	mh1	NOUN
bjp-20418	8	21	)	)	PUNCT
bjp-20418	8	22	and	and	CCONJ
bjp-20418	8	23	a	a	DET
bjp-20418	8	24	c	c	NOUN
bjp-20418	8	25	-	-	PUNCT
bjp-20418	8	26	terminal	terminal	ADJ
bjp-20418	8	27	mad	mad	ADJ
bjp-20418	8	28	homology	homology	NOUN
bjp-20418	8	29	domain-2	domain-2	X
bjp-20418	8	30	(	(	PUNCT
bjp-20418	8	31	mh2	mh2	PROPN
bjp-20418	8	32	)	)	PUNCT
bjp-20418	8	33	(	(	PUNCT
bjp-20418	8	34	frederick	frederick	PROPN
bjp-20418	8	35	et	et	PROPN
bjp-20418	8	36	al	al	PROPN
bjp-20418	8	37	.	.	PROPN
bjp-20418	8	38	,	,	PUNCT
bjp-20418	8	39	2002	2002	NUM
bjp-20418	8	40	;	;	PUNCT
bjp-20418	8	41	miyazono	miyazono	X
bjp-20418	8	42	et	et	PROPN
bjp-20418	8	43	al	al	PROPN
bjp-20418	8	44	.	.	PROPN
bjp-20418	8	45	,	,	PUNCT
bjp-20418	8	46	2000	2000	NUM
bjp-20418	8	47	)	)	PUNCT
bjp-20418	8	48	.	.	PUNCT
bjp-20418	9	1	the	the	DET
bjp-20418	9	2	mh1	mh1	PROPN
bjp-20418	9	3	domain	domain	NOUN
bjp-20418	9	4	regulates	regulate	VERB
bjp-20418	9	5	the	the	DET
bjp-20418	9	6	nuclear	nuclear	ADJ
bjp-20418	9	7	import	import	NOUN
bjp-20418	9	8	,	,	PUNCT
bjp-20418	9	9	dna	dna	NOUN
bjp-20418	9	10	binding	bind	VERB
bjp-20418	9	11	and	and	CCONJ
bjp-20418	9	12	transcriptional	transcriptional	ADJ
bjp-20418	9	13	activity	activity	NOUN
bjp-20418	9	14	,	,	PUNCT
bjp-20418	9	15	while	while	SCONJ
bjp-20418	9	16	the	the	DET
bjp-20418	9	17	mh2	mh2	NOUN
bjp-20418	9	18	domain	domain	NOUN
bjp-20418	9	19	mediates	mediate	NOUN
bjp-20418	9	20	smad	smad	VERB
bjp-20418	9	21	protein	protein	NOUN
bjp-20418	9	22	homo	homo	NOUN
bjp-20418	9	23	and	and	CCONJ
bjp-20418	9	24	hetero	hetero	NOUN
bjp-20418	9	25	-	-	PUNCT
bjp-20418	9	26	oligomerization	oligomerization	NOUN
bjp-20418	9	27	,	,	PUNCT
bjp-20418	9	28	and	and	CCONJ
bjp-20418	9	29	cytoplasmic	cytoplasmic	ADJ
bjp-20418	9	30	anchoring	anchoring	NOUN
bjp-20418	9	31	(	(	PUNCT
bjp-20418	9	32	frederick	frederick	PROPN
bjp-20418	9	33	et	et	PROPN
bjp-20418	9	34	al	al	PROPN
bjp-20418	9	35	.	.	PROPN
bjp-20418	9	36	,	,	PUNCT
bjp-20418	9	37	2002	2002	NUM
bjp-20418	9	38	;	;	PUNCT
bjp-20418	9	39	miyazono	miyazono	X
bjp-20418	9	40	et	et	PROPN
bjp-20418	9	41	al	al	PROPN
bjp-20418	9	42	.	.	PROPN
bjp-20418	9	43	,	,	PUNCT
bjp-20418	9	44	2000	2000	NUM
bjp-20418	9	45	)	)	PUNCT
bjp-20418	9	46	.	.	PUNCT
bjp-20418	10	1	mutations	mutation	NOUN
bjp-20418	10	2	in	in	ADP
bjp-20418	10	3	smads	smad	NOUN
bjp-20418	10	4	,	,	PUNCT
bjp-20418	10	5	in	in	ADP
bjp-20418	10	6	particular	particular	ADJ
bjp-20418	10	7	smad4	smad4	NOUN
bjp-20418	10	8	,	,	PUNCT
bjp-20418	10	9	show	show	VERB
bjp-20418	10	10	a	a	DET
bjp-20418	10	11	characteristic	characteristic	ADJ
bjp-20418	10	12	distribution	distribution	NOUN
bjp-20418	10	13	with	with	ADP
bjp-20418	10	14	respect	respect	NOUN
bjp-20418	10	15	to	to	ADP
bjp-20418	10	16	its	its	PRON
bjp-20418	10	17	domain	domain	NOUN
bjp-20418	10	18	structure	structure	NOUN
bjp-20418	10	19	.	.	PUNCT
bjp-20418	11	1	the	the	DET
bjp-20418	11	2	majority	majority	NOUN
bjp-20418	11	3	of	of	ADP
bjp-20418	11	4	changes	change	NOUN
bjp-20418	11	5	cluster	cluster	NOUN
bjp-20418	11	6	in	in	ADP
bjp-20418	11	7	the	the	DET
bjp-20418	11	8	mh2	mh2	NOUN
bjp-20418	11	9	domain	domain	NOUN
bjp-20418	11	10	and	and	CCONJ
bjp-20418	11	11	often	often	ADV
bjp-20418	11	12	altering	alter	VERB
bjp-20418	11	13	smad4	smad4	NOUN
bjp-20418	11	14	hetero	hetero	NOUN
bjp-20418	11	15	-	-	PUNCT
bjp-20418	11	16	oligomerization	oligomerization	NOUN
bjp-20418	11	17	with	with	ADP
bjp-20418	11	18	the	the	DET
bjp-20418	11	19	r	r	NOUN
bjp-20418	11	20	-	-	PUNCT
bjp-20418	11	21	smads	smad	NOUN
bjp-20418	11	22	(	(	PUNCT
bjp-20418	11	23	fleming	fleme	VERB
bjp-20418	11	24	et	et	PROPN
bjp-20418	11	25	al	al	PROPN
bjp-20418	11	26	.	.	PROPN
bjp-20418	11	27	,	,	PUNCT
bjp-20418	11	28	2013	2013	NUM
bjp-20418	11	29	)	)	PUNCT
bjp-20418	11	30	.	.	PUNCT
bjp-20418	12	1	despite	despite	SCONJ
bjp-20418	12	2	the	the	DET
bjp-20418	12	3	smad	smad	PROPN
bjp-20418	12	4	protein	protein	NOUN
bjp-20418	12	5	functions	function	NOUN
bjp-20418	12	6	is	be	AUX
bjp-20418	12	7	known	know	VERB
bjp-20418	12	8	in	in	ADP
bjp-20418	12	9	the	the	DET
bjp-20418	12	10	onset	onset	NOUN
bjp-20418	12	11	and	and	CCONJ
bjp-20418	12	12	the	the	DET
bjp-20418	12	13	progression	progression	NOUN
bjp-20418	12	14	of	of	ADP
bjp-20418	12	15	crc	crc	NOUN
bjp-20418	12	16	cancer	cancer	NOUN
bjp-20418	12	17	,	,	PUNCT
bjp-20418	12	18	evidence	evidence	NOUN
bjp-20418	12	19	for	for	ADP
bjp-20418	12	20	their	their	PRON
bjp-20418	12	21	role	role	NOUN
bjp-20418	12	22	in	in	ADP
bjp-20418	12	23	modulating	modulate	VERB
bjp-20418	12	24	the	the	DET
bjp-20418	12	25	drug	drug	NOUN
bjp-20418	12	26	responses	response	NOUN
bjp-20418	12	27	is	be	AUX
bjp-20418	12	28	limited	limited	ADJ
bjp-20418	12	29	.	.	PUNCT
bjp-20418	13	1	a	a	DET
bjp-20418	13	2	journal	journal	NOUN
bjp-20418	13	3	of	of	ADP
bjp-20418	13	4	the	the	DET
bjp-20418	13	5	bangladesh	bangladesh	NOUN
bjp-20418	13	6	pharmacological	pharmacological	ADJ
bjp-20418	13	7	society	society	NOUN
bjp-20418	13	8	(	(	PUNCT
bjp-20418	13	9	bdps	bdps	NOUN
bjp-20418	13	10	)	)	PUNCT
bjp-20418	13	11	bangladesh	bangladesh	PROPN
bjp-20418	13	12	j	j	PROPN
bjp-20418	13	13	pharmacol	pharmacol	PROPN
bjp-20418	13	14	2014	2014	NUM
bjp-20418	13	15	;	;	PUNCT
bjp-20418	13	16	9	9	NUM
bjp-20418	13	17	:	:	SYM
bjp-20418	13	18	539	539	NUM
bjp-20418	13	19	-	-	SYM
bjp-20418	13	20	44	44	NUM
bjp-20418	13	21	journal	journal	NOUN
bjp-20418	13	22	homepage	homepage	NOUN
bjp-20418	13	23	:	:	PUNCT
bjp-20418	13	24	www.banglajol.info	www.banglajol.info	PROPN
bjp-20418	13	25	abstracted	abstract	VERB
bjp-20418	13	26	/	/	SYM
bjp-20418	13	27	indexed	index	VERB
bjp-20418	13	28	in	in	ADP
bjp-20418	13	29	academic	academic	ADJ
bjp-20418	13	30	search	search	NOUN
bjp-20418	13	31	complete	complete	ADJ
bjp-20418	13	32	,	,	PUNCT
bjp-20418	13	33	agroforestry	agroforestry	NOUN
bjp-20418	13	34	abstracts	abstract	NOUN
bjp-20418	13	35	,	,	PUNCT
bjp-20418	13	36	asia	asia	PROPN
bjp-20418	13	37	journals	journal	NOUN
bjp-20418	13	38	online	online	ADV
bjp-20418	13	39	,	,	PUNCT
bjp-20418	13	40	bangladesh	bangladesh	NOUN
bjp-20418	13	41	journals	journal	NOUN
bjp-20418	13	42	online	online	ADV
bjp-20418	13	43	,	,	PUNCT
bjp-20418	13	44	biological	biological	ADJ
bjp-20418	13	45	abstracts	abstract	NOUN
bjp-20418	13	46	,	,	PUNCT
bjp-20418	13	47	biosis	biosis	NOUN
bjp-20418	13	48	previews	preview	NOUN
bjp-20418	13	49	,	,	PUNCT
bjp-20418	13	50	cab	cab	NOUN
bjp-20418	13	51	abstracts	abstract	NOUN
bjp-20418	13	52	,	,	PUNCT
bjp-20418	13	53	current	current	ADJ
bjp-20418	13	54	abstracts	abstract	NOUN
bjp-20418	13	55	,	,	PUNCT
bjp-20418	13	56	directory	directory	NOUN
bjp-20418	13	57	of	of	ADP
bjp-20418	13	58	open	open	ADJ
bjp-20418	13	59	access	access	NOUN
bjp-20418	13	60	journals	journal	NOUN
bjp-20418	13	61	,	,	PUNCT
bjp-20418	13	62	embase	embase	NOUN
bjp-20418	13	63	/	/	SYM
bjp-20418	13	64	excerpta	excerpta	NOUN
bjp-20418	13	65	medica	medica	NOUN
bjp-20418	13	66	,	,	PUNCT
bjp-20418	13	67	global	global	ADJ
bjp-20418	13	68	health	health	NOUN
bjp-20418	13	69	,	,	PUNCT
bjp-20418	13	70	google	google	PROPN
bjp-20418	13	71	scholar	scholar	NOUN
bjp-20418	13	72	,	,	PUNCT
bjp-20418	13	73	hinari	hinari	X
bjp-20418	13	74	(	(	PUNCT
bjp-20418	13	75	who	who	PRON
bjp-20418	13	76	)	)	PUNCT
bjp-20418	13	77	,	,	PUNCT
bjp-20418	13	78	international	international	ADJ
bjp-20418	13	79	pharmaceutical	pharmaceutical	ADJ
bjp-20418	13	80	abstracts	abstract	NOUN
bjp-20418	13	81	,	,	PUNCT
bjp-20418	13	82	open	open	ADJ
bjp-20418	13	83	j	j	PROPN
bjp-20418	13	84	-	-	PUNCT
bjp-20418	13	85	gate	gate	NOUN
bjp-20418	13	86	,	,	PUNCT
bjp-20418	13	87	science	science	NOUN
bjp-20418	13	88	citation	citation	NOUN
bjp-20418	13	89	index	index	NOUN
bjp-20418	13	90	expanded	expand	VERB
bjp-20418	13	91	,	,	PUNCT
bjp-20418	13	92	scopus	scopus	NOUN
bjp-20418	13	93	and	and	CCONJ
bjp-20418	13	94	social	social	ADJ
bjp-20418	13	95	sciences	sciences	PROPN
bjp-20418	13	96	citation	citation	NOUN
bjp-20418	13	97	index	index	NOUN
bjp-20418	13	98	issn	issn	PROPN
bjp-20418	13	99	:	:	PUNCT
bjp-20418	13	100	1991	1991	NUM
bjp-20418	13	101	-	-	PUNCT
bjp-20418	13	102	0088	0088	NUM
bjp-20418	13	103	abstract	abstract	ADJ
bjp-20418	13	104	aberrations	aberration	NOUN
bjp-20418	13	105	in	in	ADP
bjp-20418	13	106	smad	smad	NOUN
bjp-20418	13	107	signaling	signal	VERB
bjp-20418	13	108	have	have	AUX
bjp-20418	13	109	been	be	AUX
bjp-20418	13	110	widely	widely	ADV
bjp-20418	13	111	associated	associate	VERB
bjp-20418	13	112	with	with	ADP
bjp-20418	13	113	colon	colon	NOUN
bjp-20418	13	114	cancer	cancer	NOUN
bjp-20418	13	115	progression	progression	NOUN
bjp-20418	13	116	.	.	PUNCT
bjp-20418	14	1	however	however	ADV
bjp-20418	14	2	,	,	PUNCT
bjp-20418	14	3	their	their	PRON
bjp-20418	14	4	significance	significance	NOUN
bjp-20418	14	5	in	in	ADP
bjp-20418	14	6	modulating	modulate	VERB
bjp-20418	14	7	drug	drug	NOUN
bjp-20418	14	8	response	response	NOUN
bjp-20418	14	9	remains	remain	VERB
bjp-20418	14	10	unknown	unknown	ADJ
bjp-20418	14	11	.	.	PUNCT
bjp-20418	15	1	in	in	ADP
bjp-20418	15	2	this	this	DET
bjp-20418	15	3	study	study	NOUN
bjp-20418	15	4	we	we	PRON
bjp-20418	15	5	investigated	investigate	VERB
bjp-20418	15	6	the	the	DET
bjp-20418	15	7	response	response	NOUN
bjp-20418	15	8	of	of	ADP
bjp-20418	15	9	chemotherapeutic	chemotherapeutic	ADJ
bjp-20418	15	10	drugs	drug	NOUN
bjp-20418	15	11	in	in	ADP
bjp-20418	15	12	colon	colon	NOUN
bjp-20418	15	13	cancer	cancer	NOUN
bjp-20418	15	14	cells	cell	NOUN
bjp-20418	15	15	that	that	PRON
bjp-20418	15	16	are	be	AUX
bjp-20418	15	17	with	with	ADP
bjp-20418	15	18	(	(	PUNCT
bjp-20418	15	19	sw620	sw620	ADJ
bjp-20418	15	20	and	and	CCONJ
bjp-20418	15	21	sw480	sw480	NOUN
bjp-20418	15	22	)	)	PUNCT
bjp-20418	15	23	and	and	CCONJ
bjp-20418	15	24	without	without	ADP
bjp-20418	15	25	aberrations	aberration	NOUN
bjp-20418	15	26	(	(	PUNCT
bjp-20418	15	27	fet-1	fet-1	NUM
bjp-20418	15	28	and	and	CCONJ
bjp-20418	15	29	caco2	caco2	NOUN
bjp-20418	15	30	)	)	PUNCT
bjp-20418	15	31	in	in	ADP
bjp-20418	15	32	smad	smad	PROPN
bjp-20418	15	33	signaling	signal	VERB
bjp-20418	15	34	.	.	PUNCT
bjp-20418	16	1	these	these	DET
bjp-20418	16	2	results	result	NOUN
bjp-20418	16	3	showed	show	VERB
bjp-20418	16	4	that	that	SCONJ
bjp-20418	16	5	curcumin	curcumin	NOUN
bjp-20418	16	6	,	,	PUNCT
bjp-20418	16	7	5	5	NUM
bjp-20418	16	8	-	-	PUNCT
bjp-20418	16	9	fluorouracil	fluorouracil	NOUN
bjp-20418	16	10	and	and	CCONJ
bjp-20418	16	11	their	their	PRON
bjp-20418	16	12	combinations	combination	NOUN
bjp-20418	16	13	induced	induce	VERB
bjp-20418	16	14	less	less	ADJ
bjp-20418	16	15	cell	cell	NOUN
bjp-20418	16	16	death	death	NOUN
bjp-20418	16	17	in	in	ADP
bjp-20418	16	18	smad	smad	PROPN
bjp-20418	16	19	signaling	signal	VERB
bjp-20418	16	20	non	non	ADJ
bjp-20418	16	21	-	-	ADJ
bjp-20418	16	22	responsive	responsive	ADJ
bjp-20418	16	23	cells	cell	NOUN
bjp-20418	16	24	,	,	PUNCT
bjp-20418	16	25	while	while	SCONJ
bjp-20418	16	26	the	the	DET
bjp-20418	16	27	apoptosis	apoptosis	NOUN
bjp-20418	16	28	was	be	AUX
bjp-20418	16	29	(	(	PUNCT
bjp-20418	16	30	>	>	X
bjp-20418	16	31	2	2	NUM
bjp-20418	16	32	fold	fold	ADJ
bjp-20418	16	33	)	)	PUNCT
bjp-20418	16	34	higher	high	ADJ
bjp-20418	16	35	in	in	ADP
bjp-20418	16	36	smad	smad	PROPN
bjp-20418	16	37	responsive	responsive	ADJ
bjp-20418	16	38	cells	cell	NOUN
bjp-20418	16	39	.	.	PUNCT
bjp-20418	17	1	furthermore	furthermore	ADV
bjp-20418	17	2	,	,	PUNCT
bjp-20418	17	3	these	these	DET
bjp-20418	17	4	results	result	NOUN
bjp-20418	17	5	showed	show	VERB
bjp-20418	17	6	that	that	SCONJ
bjp-20418	17	7	the	the	DET
bjp-20418	17	8	apoptosis	apoptosis	NOUN
bjp-20418	17	9	in	in	ADP
bjp-20418	17	10	smad	smad	PROPN
bjp-20418	17	11	non	non	ADJ
bjp-20418	17	12	-	-	ADJ
bjp-20418	17	13	responsive	responsive	ADJ
bjp-20418	17	14	cells	cell	NOUN
bjp-20418	17	15	was	be	AUX
bjp-20418	17	16	reversed	reverse	VERB
bjp-20418	17	17	and	and	CCONJ
bjp-20418	17	18	increased	increase	VERB
bjp-20418	17	19	(	(	PUNCT
bjp-20418	17	20	~2	~2	NOUN
bjp-20418	17	21	-	-	ADJ
bjp-20418	17	22	fold	fold	ADJ
bjp-20418	17	23	)	)	PUNCT
bjp-20418	17	24	upon	upon	SCONJ
bjp-20418	17	25	ectopic	ectopic	ADJ
bjp-20418	17	26	expression	expression	NOUN
bjp-20418	17	27	of	of	ADP
bjp-20418	17	28	smad-4	smad-4	PROPN
bjp-20418	17	29	.	.	PUNCT
bjp-20418	18	1	finally	finally	ADV
bjp-20418	18	2	,	,	PUNCT
bjp-20418	18	3	correlation	correlation	NOUN
bjp-20418	18	4	with	with	ADP
bjp-20418	18	5	patients	patient	NOUN
bjp-20418	18	6	undergoing	undergo	VERB
bjp-20418	18	7	chemotherapy	chemotherapy	NOUN
bjp-20418	18	8	for	for	ADP
bjp-20418	18	9	colon	colon	NOUN
bjp-20418	18	10	cancer	cancer	NOUN
bjp-20418	18	11	showed	show	VERB
bjp-20418	18	12	a	a	DET
bjp-20418	18	13	strong	strong	ADJ
bjp-20418	18	14	association	association	NOUN
bjp-20418	18	15	between	between	ADP
bjp-20418	18	16	smad	smad	PROPN
bjp-20418	18	17	aberration	aberration	NOUN
bjp-20418	18	18	and	and	CCONJ
bjp-20418	18	19	tumor	tumor	NOUN
bjp-20418	18	20	relapse	relapse	NOUN
bjp-20418	18	21	in	in	ADP
bjp-20418	18	22	chemotherapy	chemotherapy	NOUN
bjp-20418	18	23	.	.	PUNCT
bjp-20418	19	1	overall	overall	ADV
bjp-20418	19	2	,	,	PUNCT
bjp-20418	19	3	the	the	DET
bjp-20418	19	4	present	present	ADJ
bjp-20418	19	5	data	datum	NOUN
bjp-20418	19	6	showed	show	VERB
bjp-20418	19	7	that	that	SCONJ
bjp-20418	19	8	smad	smad	NOUN
bjp-20418	19	9	signaling	signal	VERB
bjp-20418	19	10	modulates	modulate	NOUN
bjp-20418	19	11	the	the	DET
bjp-20418	19	12	drug	drug	NOUN
bjp-20418	19	13	responses	response	NOUN
bjp-20418	19	14	and	and	CCONJ
bjp-20418	19	15	their	their	PRON
bjp-20418	19	16	signaling	signal	VERB
bjp-20418	19	17	status	status	NOUN
bjp-20418	19	18	should	should	AUX
bjp-20418	19	19	be	be	AUX
bjp-20418	19	20	considered	consider	VERB
bjp-20418	19	21	while	while	SCONJ
bjp-20418	19	22	designing	design	VERB
bjp-20418	19	23	chemotherapy	chemotherapy	NOUN
bjp-20418	19	24	regimen	regiman	NOUN
bjp-20418	19	25	for	for	ADP
bjp-20418	19	26	colon	colon	NOUN
bjp-20418	19	27	cancer	cancer	NOUN
bjp-20418	19	28	patients	patient	NOUN
bjp-20418	19	29	.	.	PUNCT
bjp-20418	20	1	article	article	NOUN
bjp-20418	20	2	info	info	NOUN
bjp-20418	20	3	received	receive	VERB
bjp-20418	20	4	:	:	PUNCT
bjp-20418	20	5	11	11	NUM
bjp-20418	20	6	september	september	PROPN
bjp-20418	20	7	2014	2014	NUM
bjp-20418	20	8	accepted	accept	VERB
bjp-20418	20	9	:	:	PUNCT
bjp-20418	20	10	5	5	NUM
bjp-20418	20	11	october	october	PROPN
bjp-20418	20	12	2014	2014	NUM
bjp-20418	20	13	available	available	ADJ
bjp-20418	20	14	online	online	ADV
bjp-20418	20	15	:	:	PUNCT
bjp-20418	20	16	25	25	NUM
bjp-20418	20	17	october	october	PROPN
bjp-20418	20	18	2014	2014	NUM
bjp-20418	20	19	doi	doi	NOUN
bjp-20418	20	20	:	:	PUNCT
bjp-20418	20	21	10.3329	10.3329	NUM
bjp-20418	20	22	/	/	SYM
bjp-20418	20	23	bjp.v9i4.20418	bjp.v9i4.20418	PROPN
bjp-20418	20	24	cite	cite	VERB
bjp-20418	20	25	this	this	DET
bjp-20418	20	26	article	article	NOUN
bjp-20418	20	27	:	:	PUNCT
bjp-20418	20	28	ren	ren	PROPN
bjp-20418	20	29	b	b	PROPN
bjp-20418	20	30	,	,	PUNCT
bjp-20418	20	31	liu	liu	PROPN
bjp-20418	20	32	c	c	PROPN
bjp-20418	20	33	,	,	PUNCT
bjp-20418	20	34	wu	wu	PROPN
bjp-20418	20	35	lh	lh	PROPN
bjp-20418	20	36	,	,	PUNCT
bjp-20418	20	37	jin	jin	NOUN
bjp-20418	20	38	p	p	X
bjp-20418	20	39	,	,	PUNCT
bjp-20418	20	40	li	li	PROPN
bjp-20418	20	41	p	p	PROPN
bjp-20418	20	42	,	,	PUNCT
bjp-20418	20	43	liu	liu	PROPN
bjp-20418	20	44	yj	yj	PROPN
bjp-20418	20	45	,	,	PUNCT
bjp-20418	20	46	yu	yu	PROPN
bjp-20418	20	47	qb	qb	PROPN
bjp-20418	20	48	.	.	PROPN
bjp-20418	20	49	role	role	NOUN
bjp-20418	20	50	of	of	ADP
bjp-20418	20	51	smad	smad	PROPN
bjp-20418	20	52	signaling	signal	VERB
bjp-20418	20	53	in	in	ADP
bjp-20418	20	54	drug	drug	NOUN
bjp-20418	20	55	-	-	PUNCT
bjp-20418	20	56	induced	induce	VERB
bjp-20418	20	57	apoptosis	apoptosis	NOUN
bjp-20418	20	58	in	in	ADP
bjp-20418	20	59	colon	colon	NOUN
bjp-20418	20	60	cancer	cancer	NOUN
bjp-20418	20	61	.	.	PUNCT
bjp-20418	21	1	bangladesh	bangladesh	PROPN
bjp-20418	21	2	j	j	PROPN
bjp-20418	21	3	pharmacol	pharmacol	PROPN
bjp-20418	21	4	.	.	PUNCT
bjp-20418	21	5	2014	2014	NUM
bjp-20418	21	6	;	;	PUNCT
bjp-20418	21	7	9	9	NUM
bjp-20418	21	8	:	:	SYM
bjp-20418	21	9	539	539	NUM
bjp-20418	21	10	-	-	SYM
bjp-20418	21	11	44	44	NUM
bjp-20418	21	12	.	.	PUNCT
bjp-20418	22	1	this	this	DET
bjp-20418	22	2	work	work	NOUN
bjp-20418	22	3	is	be	AUX
bjp-20418	22	4	licensed	license	VERB
bjp-20418	22	5	under	under	ADP
bjp-20418	22	6	a	a	DET
bjp-20418	22	7	creative	creative	ADJ
bjp-20418	22	8	commons	common	NOUN
bjp-20418	22	9	attribution	attribution	NOUN
bjp-20418	22	10	3.0	3.0	NUM
bjp-20418	22	11	license	license	NOUN
bjp-20418	22	12	.	.	PUNCT
bjp-20418	23	1	you	you	PRON
bjp-20418	23	2	are	be	AUX
bjp-20418	23	3	free	free	ADJ
bjp-20418	23	4	to	to	PART
bjp-20418	23	5	copy	copy	VERB
bjp-20418	23	6	,	,	PUNCT
bjp-20418	23	7	distribute	distribute	VERB
bjp-20418	23	8	and	and	CCONJ
bjp-20418	23	9	perform	perform	VERB
bjp-20418	23	10	the	the	DET
bjp-20418	23	11	work	work	NOUN
bjp-20418	23	12	.	.	PUNCT
bjp-20418	24	1	you	you	PRON
bjp-20418	24	2	must	must	AUX
bjp-20418	24	3	attribute	attribute	VERB
bjp-20418	24	4	the	the	DET
bjp-20418	24	5	work	work	NOUN
bjp-20418	24	6	in	in	ADP
bjp-20418	24	7	the	the	DET
bjp-20418	24	8	manner	manner	NOUN
bjp-20418	24	9	specified	specify	VERB
bjp-20418	24	10	by	by	ADP
bjp-20418	24	11	the	the	DET
bjp-20418	24	12	author	author	NOUN
bjp-20418	24	13	or	or	CCONJ
bjp-20418	24	14	licensor	licensor	NOUN
bjp-20418	24	15	.	.	PUNCT
bjp-20418	25	1	role	role	NOUN
bjp-20418	25	2	of	of	ADP
bjp-20418	25	3	smad	smad	PROPN
bjp-20418	25	4	signaling	signal	VERB
bjp-20418	25	5	in	in	ADP
bjp-20418	25	6	drug	drug	NOUN
bjp-20418	25	7	-	-	PUNCT
bjp-20418	25	8	induced	induce	VERB
bjp-20418	25	9	apoptosis	apoptosis	NOUN
bjp-20418	25	10	in	in	ADP
bjp-20418	25	11	colon	colon	NOUN
bjp-20418	25	12	cancer	cancer	NOUN
bjp-20418	25	13	bin	bin	PROPN
bjp-20418	25	14	ren1	ren1	PROPN
bjp-20418	25	15	,	,	PUNCT
bjp-20418	25	16	chong	chong	PROPN
bjp-20418	25	17	liu2	liu2	PROPN
bjp-20418	25	18	,	,	PUNCT
bjp-20418	25	19	li	li	PROPN
bjp-20418	25	20	hua	hua	PROPN
bjp-20418	26	1	wu3	wu3	PROPN
bjp-20418	26	2	,	,	PUNCT
bjp-20418	26	3	peng	peng	PROPN
bjp-20418	26	4	jin1	jin1	PROPN
bjp-20418	26	5	,	,	PUNCT
bjp-20418	26	6	ping	ping	PROPN
bjp-20418	26	7	li4	li4	VERB
bjp-20418	26	8	,	,	PUNCT
bjp-20418	26	9	yu	yu	PROPN
bjp-20418	26	10	jie	jie	PROPN
bjp-20418	26	11	liu1	liu1	PROPN
bjp-20418	26	12	and	and	CCONJ
bjp-20418	26	13	qing	qe	VERB
bjp-20418	27	1	bo	bo	PROPN
bjp-20418	27	2	yu5	yu5	PROPN
bjp-20418	27	3	1department	1department	NUM
bjp-20418	27	4	of	of	ADP
bjp-20418	27	5	anorectal	anorectal	ADJ
bjp-20418	27	6	surgery	surgery	NOUN
bjp-20418	27	7	,	,	PUNCT
bjp-20418	27	8	the	the	DET
bjp-20418	27	9	affiliated	affiliated	ADJ
bjp-20418	27	10	hospital	hospital	NOUN
bjp-20418	27	11	of	of	ADP
bjp-20418	27	12	weifang	weifang	PROPN
bjp-20418	27	13	medical	medical	PROPN
bjp-20418	27	14	university	university	PROPN
bjp-20418	27	15	,	,	PUNCT
bjp-20418	27	16	shandong	shandong	PROPN
bjp-20418	27	17	261031	261031	NUM
bjp-20418	27	18	,	,	PUNCT
bjp-20418	27	19	china	china	PROPN
bjp-20418	27	20	;	;	PUNCT
bjp-20418	27	21	2department	2department	NUM
bjp-20418	27	22	of	of	ADP
bjp-20418	27	23	gastrointestinal	gastrointestinal	ADJ
bjp-20418	27	24	surgery	surgery	NOUN
bjp-20418	27	25	,	,	PUNCT
bjp-20418	27	26	the	the	DET
bjp-20418	27	27	affiliated	affiliated	ADJ
bjp-20418	27	28	hospital	hospital	NOUN
bjp-20418	27	29	of	of	ADP
bjp-20418	27	30	weifang	weifang	PROPN
bjp-20418	27	31	medical	medical	PROPN
bjp-20418	27	32	university	university	PROPN
bjp-20418	27	33	,	,	PUNCT
bjp-20418	27	34	shandong	shandong	PROPN
bjp-20418	27	35	261031	261031	NUM
bjp-20418	27	36	,	,	PUNCT
bjp-20418	27	37	china	china	PROPN
bjp-20418	27	38	;	;	PUNCT
bjp-20418	27	39	3department	3department	NUM
bjp-20418	27	40	of	of	ADP
bjp-20418	27	41	public	public	ADJ
bjp-20418	27	42	health	health	NOUN
bjp-20418	27	43	,	,	PUNCT
bjp-20418	27	44	the	the	DET
bjp-20418	27	45	affiliated	affiliated	ADJ
bjp-20418	27	46	hospital	hospital	NOUN
bjp-20418	27	47	of	of	ADP
bjp-20418	27	48	weifang	weifang	PROPN
bjp-20418	27	49	medical	medical	PROPN
bjp-20418	27	50	university	university	PROPN
bjp-20418	27	51	,	,	PUNCT
bjp-20418	27	52	shandong	shandong	PROPN
bjp-20418	27	53	261031	261031	NUM
bjp-20418	27	54	,	,	PUNCT
bjp-20418	27	55	china	china	PROPN
bjp-20418	27	56	;	;	PUNCT
bjp-20418	27	57	4department	4department	NUM
bjp-20418	27	58	of	of	ADP
bjp-20418	27	59	pathology	pathology	PROPN
bjp-20418	27	60	,	,	PUNCT
bjp-20418	27	61	weifang	weifang	PROPN
bjp-20418	27	62	nursing	nursing	PROPN
bjp-20418	27	63	vocational	vocational	PROPN
bjp-20418	27	64	college	college	PROPN
bjp-20418	27	65	,	,	PUNCT
bjp-20418	27	66	shandong	shandong	PROPN
bjp-20418	27	67	261031	261031	NUM
bjp-20418	27	68	,	,	PUNCT
bjp-20418	27	69	china	china	PROPN
bjp-20418	27	70	;	;	PUNCT
bjp-20418	27	71	5department	5department	NUM
bjp-20418	27	72	of	of	ADP
bjp-20418	27	73	thyroid	thyroid	NOUN
bjp-20418	27	74	breast	breast	NOUN
bjp-20418	27	75	surgery	surgery	NOUN
bjp-20418	27	76	,	,	PUNCT
bjp-20418	27	77	the	the	DET
bjp-20418	27	78	affiliated	affiliated	ADJ
bjp-20418	27	79	hospital	hospital	NOUN
bjp-20418	27	80	of	of	ADP
bjp-20418	27	81	weifang	weifang	PROPN
bjp-20418	27	82	medical	medical	PROPN
bjp-20418	27	83	university	university	PROPN
bjp-20418	27	84	,	,	PUNCT
bjp-20418	27	85	shandong	shandong	PROPN
bjp-20418	27	86	261031	261031	NUM
bjp-20418	27	87	,	,	PUNCT
bjp-20418	27	88	china	china	PROPN
bjp-20418	27	89	.	.	PUNCT
bjp-20418	28	1	altered	alter	VERB
bjp-20418	28	2	nf	nf	PROPN
bjp-20418	28	3	-	-	PUNCT
bjp-20418	28	4	kb	kb	NOUN
bjp-20418	28	5	signaling	signal	VERB
bjp-20418	28	6	due	due	ADP
bjp-20418	28	7	to	to	ADP
bjp-20418	28	8	abnormal	abnormal	ADJ
bjp-20418	28	9	smad	smad	NOUN
bjp-20418	28	10	signaling	signal	VERB
bjp-20418	28	11	has	have	AUX
bjp-20418	28	12	been	be	AUX
bjp-20418	28	13	recently	recently	ADV
bjp-20418	28	14	implicated	implicate	VERB
bjp-20418	28	15	with	with	ADP
bjp-20418	28	16	crc	crc	NOUN
bjp-20418	28	17	cancer	cancer	NOUN
bjp-20418	28	18	cell	cell	NOUN
bjp-20418	28	19	survival	survival	NOUN
bjp-20418	28	20	(	(	PUNCT
bjp-20418	28	21	grau	grau	PROPN
bjp-20418	28	22	et	et	PROPN
bjp-20418	28	23	al	al	PROPN
bjp-20418	28	24	.	.	PROPN
bjp-20418	28	25	,	,	PUNCT
bjp-20418	28	26	2006	2006	NUM
bjp-20418	28	27	)	)	PUNCT
bjp-20418	28	28	.	.	PUNCT
bjp-20418	29	1	however	however	ADV
bjp-20418	29	2	,	,	PUNCT
bjp-20418	29	3	a	a	DET
bjp-20418	29	4	direct	direct	ADJ
bjp-20418	29	5	evidence	evidence	NOUN
bjp-20418	29	6	for	for	ADP
bjp-20418	29	7	smad	smad	NOUN
bjp-20418	29	8	signaling	signal	VERB
bjp-20418	29	9	to	to	PART
bjp-20418	29	10	modulate	modulate	VERB
bjp-20418	29	11	the	the	DET
bjp-20418	29	12	druginduced	druginduced	ADJ
bjp-20418	29	13	apoptosis	apoptosis	NOUN
bjp-20418	29	14	is	be	AUX
bjp-20418	29	15	not	not	PART
bjp-20418	29	16	known	know	VERB
bjp-20418	29	17	.	.	PUNCT
bjp-20418	30	1	in	in	ADP
bjp-20418	30	2	the	the	DET
bjp-20418	30	3	present	present	ADJ
bjp-20418	30	4	study	study	NOUN
bjp-20418	30	5	,	,	PUNCT
bjp-20418	30	6	the	the	DET
bjp-20418	30	7	smad	smad	NOUN
bjp-20418	30	8	signaling	signal	VERB
bjp-20418	30	9	activation	activation	NOUN
bjp-20418	30	10	using	use	VERB
bjp-20418	30	11	smad4	smad4	NOUN
bjp-20418	30	12	protein	protein	NOUN
bjp-20418	30	13	levels	level	NOUN
bjp-20418	30	14	as	as	SCONJ
bjp-20418	30	15	readout	readout	VERB
bjp-20418	30	16	in	in	ADP
bjp-20418	30	17	drug	drug	NOUN
bjp-20418	30	18	induced	induce	VERB
bjp-20418	30	19	apoptosis	apoptosis	NOUN
bjp-20418	30	20	in	in	ADP
bjp-20418	30	21	colon	colon	NOUN
bjp-20418	30	22	cancer	cancer	NOUN
bjp-20418	30	23	cells	cell	NOUN
bjp-20418	30	24	were	be	AUX
bjp-20418	30	25	studied	study	VERB
bjp-20418	30	26	.	.	PUNCT
bjp-20418	31	1	materials	material	NOUN
bjp-20418	31	2	and	and	CCONJ
bjp-20418	31	3	methods	method	NOUN
bjp-20418	31	4	cell	cell	NOUN
bjp-20418	31	5	culture	culture	NOUN
bjp-20418	31	6	,	,	PUNCT
bjp-20418	31	7	treatments	treatment	NOUN
bjp-20418	31	8	and	and	CCONJ
bjp-20418	31	9	over	over	ADP
bjp-20418	31	10	expression	expression	NOUN
bjp-20418	31	11	human	human	ADJ
bjp-20418	31	12	colo	colo	ADJ
bjp-20418	31	13	-	-	PUNCT
bjp-20418	31	14	rectal	rectal	ADJ
bjp-20418	31	15	cells	cell	NOUN
bjp-20418	31	16	(	(	PUNCT
bjp-20418	31	17	caco2	caco2	NOUN
bjp-20418	31	18	,	,	PUNCT
bjp-20418	31	19	fet	fet	PROPN
bjp-20418	31	20	,	,	PUNCT
bjp-20418	31	21	sw620	sw620	NOUN
bjp-20418	31	22	and	and	CCONJ
bjp-20418	31	23	sw480	sw480	PROPN
bjp-20418	31	24	)	)	PUNCT
bjp-20418	31	25	were	be	AUX
bjp-20418	31	26	purchased	purchase	VERB
bjp-20418	31	27	from	from	ADP
bjp-20418	31	28	atcc	atcc	NOUN
bjp-20418	31	29	and	and	CCONJ
bjp-20418	31	30	maintained	maintain	VERB
bjp-20418	31	31	in	in	ADP
bjp-20418	31	32	dmem	dmem	PROPN
bjp-20418	31	33	(	(	PUNCT
bjp-20418	31	34	invitrogen	invitrogen	PROPN
bjp-20418	31	35	,	,	PUNCT
bjp-20418	31	36	ny	ny	PROPN
bjp-20418	31	37	,	,	PUNCT
bjp-20418	31	38	usa	usa	PROPN
bjp-20418	31	39	)	)	PUNCT
bjp-20418	31	40	supplemented	supplement	VERB
bjp-20418	31	41	with	with	ADP
bjp-20418	31	42	10	10	NUM
bjp-20418	31	43	%	%	NOUN
bjp-20418	31	44	fbs	fbs	ADJ
bjp-20418	31	45	.	.	PUNCT
bjp-20418	32	1	the	the	DET
bjp-20418	32	2	drugs	drug	NOUN
bjp-20418	32	3	(	(	PUNCT
bjp-20418	32	4	curcumin	curcumin	NOUN
bjp-20418	32	5	and	and	CCONJ
bjp-20418	32	6	5	5	NUM
bjp-20418	32	7	-	-	PUNCT
bjp-20418	32	8	fluorouracil	fluorouracil	NOUN
bjp-20418	32	9	)	)	PUNCT
bjp-20418	32	10	were	be	AUX
bjp-20418	32	11	purchased	purchase	VERB
bjp-20418	32	12	from	from	ADP
bjp-20418	32	13	sigma	sigma	PROPN
bjp-20418	32	14	,	,	PUNCT
bjp-20418	32	15	mo	mo	PROPN
bjp-20418	32	16	,	,	PUNCT
bjp-20418	32	17	usa	usa	PROPN
bjp-20418	32	18	.	.	PROPN
bjp-20418	32	19	5	5	NUM
bjp-20418	32	20	µm	µm	ADP
bjp-20418	32	21	treatments	treatment	NOUN
bjp-20418	32	22	were	be	AUX
bjp-20418	32	23	given	give	VERB
bjp-20418	32	24	to	to	ADP
bjp-20418	32	25	cells	cell	NOUN
bjp-20418	32	26	in	in	ADP
bjp-20418	32	27	all	all	DET
bjp-20418	32	28	experiments	experiment	NOUN
bjp-20418	32	29	,	,	PUNCT
bjp-20418	32	30	as	as	SCONJ
bjp-20418	32	31	it	it	PRON
bjp-20418	32	32	is	be	AUX
bjp-20418	32	33	the	the	DET
bjp-20418	32	34	lowest	low	ADJ
bjp-20418	32	35	of	of	ADP
bjp-20418	32	36	all	all	DET
bjp-20418	32	37	ic50	ic50	PROPN
bjp-20418	32	38	concentration	concentration	NOUN
bjp-20418	32	39	determined	determine	VERB
bjp-20418	32	40	for	for	ADP
bjp-20418	32	41	all	all	DET
bjp-20418	32	42	drug	drug	NOUN
bjp-20418	32	43	treatments	treatment	NOUN
bjp-20418	32	44	in	in	ADP
bjp-20418	32	45	the	the	DET
bjp-20418	32	46	tested	test	VERB
bjp-20418	32	47	cell	cell	NOUN
bjp-20418	32	48	lines	line	NOUN
bjp-20418	32	49	(	(	PUNCT
bjp-20418	32	50	data	datum	NOUN
bjp-20418	32	51	not	not	PART
bjp-20418	32	52	shown	show	VERB
bjp-20418	32	53	)	)	PUNCT
bjp-20418	32	54	.	.	PUNCT
bjp-20418	33	1	for	for	ADP
bjp-20418	33	2	smad4	smad4	NOUN
bjp-20418	33	3	over	over	ADP
bjp-20418	33	4	-	-	PUNCT
bjp-20418	33	5	expression	expression	NOUN
bjp-20418	33	6	experiments	experiment	NOUN
bjp-20418	33	7	,	,	PUNCT
bjp-20418	33	8	smad4	smad4	NOUN
bjp-20418	33	9	-	-	PUNCT
bjp-20418	33	10	egfpc1	egfpc1	NOUN
bjp-20418	33	11	plasmid	plasmid	NOUN
bjp-20418	33	12	was	be	AUX
bjp-20418	33	13	constructed	construct	VERB
bjp-20418	33	14	and	and	CCONJ
bjp-20418	33	15	transfected	transfecte	VERB
bjp-20418	33	16	using	use	VERB
bjp-20418	33	17	lipofectamine	lipofectamine	ADJ
bjp-20418	33	18	2000	2000	NUM
bjp-20418	33	19	(	(	PUNCT
bjp-20418	33	20	invitrogen	invitrogen	PROPN
bjp-20418	33	21	,	,	PUNCT
bjp-20418	33	22	ny	ny	PROPN
bjp-20418	33	23	,	,	PUNCT
bjp-20418	33	24	usa	usa	PROPN
bjp-20418	33	25	)	)	PUNCT
bjp-20418	33	26	,	,	PUNCT
bjp-20418	33	27	and	and	CCONJ
bjp-20418	33	28	enriched	enrich	VERB
bjp-20418	33	29	by	by	ADP
bjp-20418	33	30	geniticin	geniticin	NOUN
bjp-20418	33	31	selection	selection	NOUN
bjp-20418	33	32	(	(	PUNCT
bjp-20418	33	33	invitrogen	invitrogen	PROPN
bjp-20418	33	34	,	,	PUNCT
bjp-20418	33	35	usa	usa	PROPN
bjp-20418	33	36	)	)	PUNCT
bjp-20418	33	37	.	.	PUNCT
bjp-20418	34	1	viability	viability	NOUN
bjp-20418	34	2	assay	assay	VERB
bjp-20418	34	3	the	the	DET
bjp-20418	34	4	growth	growth	NOUN
bjp-20418	34	5	-	-	PUNCT
bjp-20418	34	6	inhibitory	inhibitory	ADJ
bjp-20418	34	7	effects	effect	NOUN
bjp-20418	34	8	of	of	ADP
bjp-20418	34	9	drugs	drug	NOUN
bjp-20418	34	10	were	be	AUX
bjp-20418	34	11	examined	examine	VERB
bjp-20418	34	12	using	use	VERB
bjp-20418	34	13	a	a	DET
bjp-20418	34	14	3	3	NUM
bjp-20418	34	15	,	,	PUNCT
bjp-20418	34	16	4	4	NUM
bjp-20418	34	17	,	,	PUNCT
bjp-20418	34	18	5	5	NUM
bjp-20418	34	19	-	-	PUNCT
bjp-20418	34	20	dimethyl-2h	dimethyl-2h	NOUN
bjp-20418	34	21	-	-	PUNCT
bjp-20418	34	22	tetrazolium	tetrazolium	NOUN
bjp-20418	34	23	bromide	bromide	NOUN
bjp-20418	34	24	assay	assay	NOUN
bjp-20418	34	25	(	(	PUNCT
bjp-20418	34	26	mtt	mtt	X
bjp-20418	34	27	;	;	PUNCT
bjp-20418	34	28	sigma‑aldrich	sigma‑aldrich	PRON
bjp-20418	34	29	)	)	PUNCT
bjp-20418	34	30	,	,	PUNCT
bjp-20418	34	31	as	as	ADP
bjp-20418	34	32	per	per	ADP
bjp-20418	34	33	manufacturer	manufacturer	NOUN
bjp-20418	34	34	’s	’s	PART
bjp-20418	34	35	instructions	instruction	NOUN
bjp-20418	34	36	.	.	PUNCT
bjp-20418	35	1	briefly	briefly	ADV
bjp-20418	35	2	,	,	PUNCT
bjp-20418	35	3	equal	equal	ADJ
bjp-20418	35	4	numbers	number	NOUN
bjp-20418	35	5	of	of	ADP
bjp-20418	35	6	cells	cell	NOUN
bjp-20418	35	7	were	be	AUX
bjp-20418	35	8	incubated	incubate	VERB
bjp-20418	35	9	with	with	ADP
bjp-20418	35	10	drugs	drug	NOUN
bjp-20418	35	11	or	or	CCONJ
bjp-20418	35	12	dmso	dmso	ADJ
bjp-20418	35	13	treatments	treatment	NOUN
bjp-20418	35	14	for	for	ADP
bjp-20418	35	15	24	24	NUM
bjp-20418	35	16	hours	hour	NOUN
bjp-20418	35	17	,	,	PUNCT
bjp-20418	35	18	followed	follow	VERB
bjp-20418	35	19	by	by	ADP
bjp-20418	35	20	additional	additional	ADJ
bjp-20418	35	21	incubation	incubation	NOUN
bjp-20418	35	22	with	with	ADP
bjp-20418	35	23	mtt	mtt	NOUN
bjp-20418	35	24	for	for	ADP
bjp-20418	35	25	4	4	NUM
bjp-20418	35	26	hours	hour	NOUN
bjp-20418	35	27	.	.	PUNCT
bjp-20418	36	1	the	the	DET
bjp-20418	36	2	mtt	mtt	NOUN
bjp-20418	36	3	formazan	formazan	NOUN
bjp-20418	36	4	was	be	AUX
bjp-20418	36	5	then	then	ADV
bjp-20418	36	6	measured	measure	VERB
bjp-20418	36	7	and	and	CCONJ
bjp-20418	36	8	used	use	VERB
bjp-20418	36	9	as	as	ADP
bjp-20418	36	10	a	a	DET
bjp-20418	36	11	quantitative	quantitative	ADJ
bjp-20418	36	12	measure	measure	NOUN
bjp-20418	36	13	of	of	ADP
bjp-20418	36	14	cell	cell	NOUN
bjp-20418	36	15	viability	viability	NOUN
bjp-20418	36	16	.	.	PUNCT
bjp-20418	37	1	the	the	DET
bjp-20418	37	2	value	value	NOUN
bjp-20418	37	3	obtained	obtain	VERB
bjp-20418	37	4	in	in	ADP
bjp-20418	37	5	control	control	NOUN
bjp-20418	37	6	was	be	AUX
bjp-20418	37	7	set	set	VERB
bjp-20418	37	8	as	as	ADP
bjp-20418	37	9	reference	reference	NOUN
bjp-20418	37	10	and	and	CCONJ
bjp-20418	37	11	relative	relative	ADJ
bjp-20418	37	12	difference	difference	NOUN
bjp-20418	37	13	in	in	ADP
bjp-20418	37	14	percent	percent	NOUN
bjp-20418	37	15	viability	viability	NOUN
bjp-20418	37	16	is	be	AUX
bjp-20418	37	17	used	use	VERB
bjp-20418	37	18	to	to	ADP
bjp-20418	37	19	efficacy	efficacy	NOUN
bjp-20418	37	20	of	of	ADP
bjp-20418	37	21	drug	drug	NOUN
bjp-20418	37	22	treatments	treatment	NOUN
bjp-20418	37	23	.	.	PUNCT
bjp-20418	38	1	ethidium	ethidium	NOUN
bjp-20418	38	2	bromide	bromide	NOUN
bjp-20418	38	3	and	and	CCONJ
bjp-20418	38	4	acridine	acridine	PROPN
bjp-20418	38	5	orange	orange	PROPN
bjp-20418	38	6	(	(	PUNCT
bjp-20418	38	7	et	et	NOUN
bjp-20418	38	8	-	-	PUNCT
bjp-20418	38	9	br	br	NOUN
bjp-20418	38	10	/	/	SYM
bjp-20418	38	11	ao	ao	NOUN
bjp-20418	38	12	)	)	PUNCT
bjp-20418	38	13	staining	stain	VERB
bjp-20418	38	14	live	live	ADV
bjp-20418	38	15	and	and	CCONJ
bjp-20418	38	16	apoptotic	apoptotic	ADJ
bjp-20418	38	17	cells	cell	NOUN
bjp-20418	38	18	were	be	AUX
bjp-20418	38	19	differentiated	differentiate	VERB
bjp-20418	38	20	from	from	ADP
bjp-20418	38	21	others	other	NOUN
bjp-20418	38	22	by	by	ADP
bjp-20418	38	23	acridine	acridine	PROPN
bjp-20418	38	24	orange	orange	PROPN
bjp-20418	38	25	(	(	PUNCT
bjp-20418	38	26	ao	ao	PROPN
bjp-20418	38	27	)	)	PUNCT
bjp-20418	38	28	and	and	CCONJ
bjp-20418	38	29	ethidium	ethidium	NOUN
bjp-20418	38	30	bromide	bromide	NOUN
bjp-20418	38	31	(	(	PUNCT
bjp-20418	38	32	et	et	NOUN
bjp-20418	38	33	-	-	PUNCT
bjp-20418	38	34	br	br	NOUN
bjp-20418	38	35	)	)	PUNCT
bjp-20418	38	36	staining	stain	VERB
bjp-20418	38	37	as	as	SCONJ
bjp-20418	38	38	described	describe	VERB
bjp-20418	38	39	previously	previously	ADV
bjp-20418	38	40	(	(	PUNCT
bjp-20418	38	41	sang	sing	VERB
bjp-20418	38	42	et	et	PROPN
bjp-20418	38	43	al	al	PROPN
bjp-20418	38	44	.	.	PROPN
bjp-20418	38	45	,	,	PUNCT
bjp-20418	38	46	2014	2014	NUM
bjp-20418	38	47	)	)	PUNCT
bjp-20418	38	48	.	.	PUNCT
bjp-20418	39	1	stained	stain	VERB
bjp-20418	39	2	cells	cell	NOUN
bjp-20418	39	3	were	be	AUX
bjp-20418	39	4	analyzed	analyze	VERB
bjp-20418	39	5	immediately	immediately	ADV
bjp-20418	39	6	by	by	ADP
bjp-20418	39	7	counting	count	VERB
bjp-20418	39	8	from	from	ADP
bjp-20418	39	9	at	at	ADV
bjp-20418	39	10	least	least	ADV
bjp-20418	39	11	three	three	NUM
bjp-20418	39	12	random	random	ADJ
bjp-20418	39	13	in	in	ADP
bjp-20418	39	14	each	each	DET
bjp-20418	39	15	experiment	experiment	NOUN
bjp-20418	39	16	.	.	PUNCT
bjp-20418	40	1	mean	mean	ADJ
bjp-20418	40	2	value	value	NOUN
bjp-20418	40	3	from	from	ADP
bjp-20418	40	4	at	at	ADV
bjp-20418	40	5	least	least	ADV
bjp-20418	40	6	three	three	NUM
bjp-20418	40	7	independent	independent	ADJ
bjp-20418	40	8	experiments	experiment	NOUN
bjp-20418	40	9	were	be	AUX
bjp-20418	40	10	provided	provide	VERB
bjp-20418	40	11	.	.	PUNCT
bjp-20418	41	1	western	western	ADJ
bjp-20418	41	2	blotting	blotting	ADJ
bjp-20418	41	3	total	total	ADJ
bjp-20418	41	4	protein	protein	NOUN
bjp-20418	41	5	from	from	ADP
bjp-20418	41	6	cells	cell	NOUN
bjp-20418	41	7	was	be	AUX
bjp-20418	41	8	extracted	extract	VERB
bjp-20418	41	9	in	in	ADP
bjp-20418	41	10	lysis	lysis	NOUN
bjp-20418	41	11	buffer	buffer	NOUN
bjp-20418	41	12	(	(	PUNCT
bjp-20418	41	13	pierce	pierce	PROPN
bjp-20418	41	14	,	,	PUNCT
bjp-20418	41	15	rockford	rockford	PROPN
bjp-20418	41	16	,	,	PUNCT
bjp-20418	41	17	il	il	PROPN
bjp-20418	41	18	,	,	PUNCT
bjp-20418	41	19	usa	usa	PROPN
bjp-20418	41	20	)	)	PUNCT
bjp-20418	41	21	and	and	CCONJ
bjp-20418	41	22	quantified	quantify	VERB
bjp-20418	41	23	using	use	VERB
bjp-20418	41	24	the	the	DET
bjp-20418	41	25	bradford	bradford	PROPN
bjp-20418	41	26	method	method	NOUN
bjp-20418	41	27	.	.	PUNCT
bjp-20418	42	1	a	a	DET
bjp-20418	42	2	total	total	NOUN
bjp-20418	42	3	of	of	ADP
bjp-20418	42	4	30	30	NUM
bjp-20418	42	5	μg	μg	NOUN
bjp-20418	42	6	of	of	ADP
bjp-20418	42	7	protein	protein	NOUN
bjp-20418	42	8	was	be	AUX
bjp-20418	42	9	separated	separate	VERB
bjp-20418	42	10	using	use	VERB
bjp-20418	42	11	4	4	NUM
bjp-20418	42	12	-	-	SYM
bjp-20418	42	13	12	12	NUM
bjp-20418	42	14	%	%	NOUN
bjp-20418	42	15	bis	bis	ADJ
bjp-20418	42	16	-	-	ADJ
bjp-20418	42	17	tris	tris	ADJ
bjp-20418	42	18	gel	gel	NOUN
bjp-20418	42	19	and	and	CCONJ
bjp-20418	42	20	then	then	ADV
bjp-20418	42	21	transferred	transfer	VERB
bjp-20418	42	22	to	to	ADP
bjp-20418	42	23	a	a	DET
bjp-20418	42	24	pvdf	pvdf	PROPN
bjp-20418	42	25	membrane	membrane	NOUN
bjp-20418	42	26	(	(	PUNCT
bjp-20418	42	27	millipore	millipore	PROPN
bjp-20418	42	28	,	,	PUNCT
bjp-20418	42	29	bedford	bedford	PROPN
bjp-20418	42	30	,	,	PUNCT
bjp-20418	42	31	ma	ma	PROPN
bjp-20418	42	32	)	)	PUNCT
bjp-20418	42	33	.	.	PUNCT
bjp-20418	43	1	the	the	DET
bjp-20418	43	2	membrane	membrane	NOUN
bjp-20418	43	3	was	be	AUX
bjp-20418	43	4	blocked	block	VERB
bjp-20418	43	5	with	with	ADP
bjp-20418	43	6	5	5	NUM
bjp-20418	43	7	%	%	NOUN
bjp-20418	43	8	dry	dry	ADJ
bjp-20418	43	9	milk	milk	NOUN
bjp-20418	43	10	and	and	CCONJ
bjp-20418	43	11	incubated	incubate	VERB
bjp-20418	43	12	overnight	overnight	ADV
bjp-20418	43	13	at	at	ADP
bjp-20418	43	14	4	4	NUM
bjp-20418	43	15	°	°	ADP
bjp-20418	43	16	c	c	NOUN
bjp-20418	43	17	with	with	ADP
bjp-20418	43	18	rabbit	rabbit	NOUN
bjp-20418	43	19	antibodies	antibody	NOUN
bjp-20418	43	20	against	against	ADP
bjp-20418	43	21	smad4	smad4	NOUN
bjp-20418	43	22	or	or	CCONJ
bjp-20418	43	23	actin	actin	NOUN
bjp-20418	43	24	(	(	PUNCT
bjp-20418	43	25	1:1000	1:1000	NUM
bjp-20418	43	26	,	,	PUNCT
bjp-20418	43	27	cell	cell	NOUN
bjp-20418	43	28	signaling	signaling	NOUN
bjp-20418	43	29	,	,	PUNCT
bjp-20418	43	30	usa	usa	PROPN
bjp-20418	43	31	)	)	PUNCT
bjp-20418	43	32	.	.	PUNCT
bjp-20418	44	1	after	after	ADP
bjp-20418	44	2	subsequent	subsequent	ADJ
bjp-20418	44	3	incubation	incubation	NOUN
bjp-20418	44	4	with	with	ADP
bjp-20418	44	5	secondary	secondary	ADJ
bjp-20418	44	6	antibodies	antibody	NOUN
bjp-20418	44	7	,	,	PUNCT
bjp-20418	44	8	membrane	membrane	NOUN
bjp-20418	44	9	was	be	AUX
bjp-20418	44	10	developed	develop	VERB
bjp-20418	44	11	with	with	ADP
bjp-20418	44	12	ecl	ecl	PROPN
bjp-20418	44	13	(	(	PUNCT
bjp-20418	44	14	pierce	pierce	PROPN
bjp-20418	44	15	,	,	PUNCT
bjp-20418	44	16	usa	usa	PROPN
bjp-20418	44	17	)	)	PUNCT
bjp-20418	44	18	and	and	CCONJ
bjp-20418	44	19	detected	detect	VERB
bjp-20418	44	20	using	use	VERB
bjp-20418	44	21	bio	bio	PROPN
bjp-20418	44	22	imaging	imaging	PROPN
bjp-20418	44	23	systems	system	NOUN
bjp-20418	44	24	(	(	PUNCT
bjp-20418	44	25	uvp	uvp	PROPN
bjp-20418	44	26	,	,	PUNCT
bjp-20418	44	27	usa	usa	PROPN
bjp-20418	44	28	)	)	PUNCT
bjp-20418	44	29	.	.	PUNCT
bjp-20418	45	1	the	the	DET
bjp-20418	45	2	relative	relative	ADJ
bjp-20418	45	3	protein	protein	NOUN
bjp-20418	45	4	levels	level	NOUN
bjp-20418	45	5	were	be	AUX
bjp-20418	45	6	calculated	calculate	VERB
bjp-20418	45	7	based	base	VERB
bjp-20418	45	8	on	on	ADP
bjp-20418	45	9	actin	actin	NOUN
bjp-20418	45	10	protein	protein	NOUN
bjp-20418	45	11	as	as	ADP
bjp-20418	45	12	a	a	DET
bjp-20418	45	13	loading	loading	NOUN
bjp-20418	45	14	control	control	NOUN
bjp-20418	45	15	.	.	PUNCT
bjp-20418	46	1	chemotherapy	chemotherapy	NOUN
bjp-20418	46	2	correlation	correlation	NOUN
bjp-20418	46	3	patient	patient	NOUN
bjp-20418	46	4	information	information	NOUN
bjp-20418	46	5	,	,	PUNCT
bjp-20418	46	6	were	be	AUX
bjp-20418	46	7	conducted	conduct	VERB
bjp-20418	46	8	as	as	ADP
bjp-20418	46	9	per	per	ADP
bjp-20418	46	10	the	the	DET
bjp-20418	46	11	institute	institute	NOUN
bjp-20418	46	12	’s	’s	PART
bjp-20418	46	13	ethical	ethical	ADJ
bjp-20418	46	14	guidelines	guideline	NOUN
bjp-20418	46	15	and	and	CCONJ
bjp-20418	46	16	under	under	ADP
bjp-20418	46	17	the	the	DET
bjp-20418	46	18	supervision	supervision	NOUN
bjp-20418	46	19	of	of	ADP
bjp-20418	46	20	weifang	weifang	PROPN
bjp-20418	46	21	medical	medical	PROPN
bjp-20418	46	22	university	university	PROPN
bjp-20418	46	23	,	,	PUNCT
bjp-20418	46	24	shandong	shandong	PROPN
bjp-20418	46	25	,	,	PUNCT
bjp-20418	46	26	china	china	PROPN
bjp-20418	46	27	.	.	PUNCT
bjp-20418	47	1	as	as	ADP
bjp-20418	47	2	evaluating	evaluate	VERB
bjp-20418	47	3	the	the	DET
bjp-20418	47	4	correlation	correlation	NOUN
bjp-20418	47	5	between	between	ADP
bjp-20418	47	6	smad	smad	PROPN
bjp-20418	47	7	mutation	mutation	NOUN
bjp-20418	47	8	and	and	CCONJ
bjp-20418	47	9	chemotherapy	chemotherapy	NOUN
bjp-20418	47	10	response	response	NOUN
bjp-20418	47	11	was	be	AUX
bjp-20418	47	12	interesting	interesting	ADJ
bjp-20418	47	13	,	,	PUNCT
bjp-20418	47	14	a	a	DET
bjp-20418	47	15	random	random	ADJ
bjp-20418	47	16	heterogeneous	heterogeneous	ADJ
bjp-20418	47	17	patient	patient	ADJ
bjp-20418	47	18	population	population	NOUN
bjp-20418	47	19	info	info	NOUN
bjp-20418	47	20	spanning	span	VERB
bjp-20418	47	21	with	with	ADP
bjp-20418	47	22	mutations	mutation	NOUN
bjp-20418	47	23	identified	identify	VERB
bjp-20418	47	24	and	and	CCONJ
bjp-20418	47	25	unidentified	unidentified	ADJ
bjp-20418	47	26	and	and	CCONJ
bjp-20418	47	27	also	also	ADV
bjp-20418	47	28	spanning	span	VERB
bjp-20418	47	29	patients	patient	NOUN
bjp-20418	47	30	with	with	ADP
bjp-20418	47	31	both	both	CCONJ
bjp-20418	47	32	positive	positive	ADJ
bjp-20418	47	33	chemotherapy	chemotherapy	NOUN
bjp-20418	47	34	response	response	NOUN
bjp-20418	47	35	and	and	CCONJ
bjp-20418	47	36	also	also	ADV
bjp-20418	47	37	with	with	ADP
bjp-20418	47	38	patient	patient	ADJ
bjp-20418	47	39	conditions	condition	NOUN
bjp-20418	47	40	with	with	ADP
bjp-20418	47	41	tumor	tumor	NOUN
bjp-20418	47	42	relapsing	relapse	VERB
bjp-20418	47	43	within	within	ADP
bjp-20418	47	44	three	three	NUM
bjp-20418	47	45	years	year	NOUN
bjp-20418	47	46	since	since	SCONJ
bjp-20418	47	47	first	first	ADJ
bjp-20418	47	48	chemotherapy	chemotherapy	NOUN
bjp-20418	47	49	were	be	AUX
bjp-20418	47	50	analyzed	analyze	VERB
bjp-20418	47	51	.	.	PUNCT
bjp-20418	48	1	three	three	NUM
bjp-20418	48	2	year	year	NOUN
bjp-20418	48	3	time	time	NOUN
bjp-20418	48	4	frame	frame	NOUN
bjp-20418	48	5	was	be	AUX
bjp-20418	48	6	selected	select	VERB
bjp-20418	48	7	to	to	PART
bjp-20418	48	8	demarcate	demarcate	VERB
bjp-20418	48	9	the	the	DET
bjp-20418	48	10	tumor	tumor	NOUN
bjp-20418	48	11	relapse	relapse	NOUN
bjp-20418	48	12	and	and	CCONJ
bjp-20418	48	13	recovery	recovery	NOUN
bjp-20418	48	14	phenotype	phenotype	NOUN
bjp-20418	48	15	,	,	PUNCT
bjp-20418	48	16	based	base	VERB
bjp-20418	48	17	on	on	ADP
bjp-20418	48	18	the	the	DET
bjp-20418	48	19	empirical	empirical	ADJ
bjp-20418	48	20	observation	observation	NOUN
bjp-20418	48	21	of	of	ADP
bjp-20418	48	22	tumor	tumor	NOUN
bjp-20418	48	23	relapse	relapse	NOUN
bjp-20418	48	24	in	in	ADP
bjp-20418	48	25	patients	patient	NOUN
bjp-20418	48	26	.	.	PUNCT
bjp-20418	49	1	however	however	ADV
bjp-20418	49	2	,	,	PUNCT
bjp-20418	49	3	there	there	PRON
bjp-20418	49	4	is	be	VERB
bjp-20418	49	5	still	still	ADV
bjp-20418	49	6	a	a	DET
bjp-20418	49	7	possibility	possibility	NOUN
bjp-20418	49	8	of	of	ADP
bjp-20418	49	9	recovered	recover	VERB
bjp-20418	49	10	patients	patient	NOUN
bjp-20418	49	11	to	to	PART
bjp-20418	49	12	have	have	AUX
bjp-20418	49	13	a	a	DET
bjp-20418	49	14	relapsed	relapse	VERB
bjp-20418	49	15	tumor	tumor	NOUN
bjp-20418	49	16	later	later	ADV
bjp-20418	49	17	than	than	ADP
bjp-20418	49	18	three	three	NUM
bjp-20418	49	19	years	year	NOUN
bjp-20418	49	20	,	,	PUNCT
bjp-20418	49	21	but	but	CCONJ
bjp-20418	49	22	per	per	ADP
bjp-20418	49	23	the	the	DET
bjp-20418	49	24	needs	need	NOUN
bjp-20418	49	25	of	of	ADP
bjp-20418	49	26	the	the	DET
bjp-20418	49	27	study	study	NOUN
bjp-20418	49	28	grouped	group	VERB
bjp-20418	49	29	based	base	VERB
bjp-20418	49	30	on	on	ADP
bjp-20418	49	31	three	three	NUM
bjp-20418	49	32	year	year	NOUN
bjp-20418	49	33	time	time	NOUN
bjp-20418	49	34	frame	frame	NOUN
bjp-20418	49	35	as	as	SCONJ
bjp-20418	49	36	most	most	ADJ
bjp-20418	49	37	tumor	tumor	NOUN
bjp-20418	49	38	relapse	relapse	NOUN
bjp-20418	49	39	would	would	AUX
bjp-20418	49	40	occur	occur	VERB
bjp-20418	49	41	well	well	ADV
bjp-20418	49	42	before	before	ADP
bjp-20418	49	43	this	this	DET
bjp-20418	49	44	time	time	NOUN
bjp-20418	49	45	frame	frame	NOUN
bjp-20418	49	46	.	.	PUNCT
bjp-20418	50	1	also	also	ADV
bjp-20418	50	2	,	,	PUNCT
bjp-20418	50	3	the	the	DET
bjp-20418	50	4	tumor	tumor	NOUN
bjp-20418	50	5	relapse	relapse	NOUN
bjp-20418	50	6	was	be	AUX
bjp-20418	50	7	based	base	VERB
bjp-20418	50	8	on	on	ADP
bjp-20418	50	9	the	the	DET
bjp-20418	50	10	primary	primary	ADJ
bjp-20418	50	11	sitehere	sitehere	NOUN
bjp-20418	50	12	it	it	PRON
bjp-20418	50	13	is	be	AUX
bjp-20418	50	14	colon	colon	NOUN
bjp-20418	50	15	cancer	cancer	NOUN
bjp-20418	50	16	.	.	PUNCT
bjp-20418	51	1	the	the	DET
bjp-20418	51	2	sample	sample	NOUN
bjp-20418	51	3	group	group	NOUN
bjp-20418	51	4	included	include	VERB
bjp-20418	51	5	both	both	DET
bjp-20418	51	6	male	male	ADJ
bjp-20418	51	7	and	and	CCONJ
bjp-20418	51	8	female	female	ADJ
bjp-20418	51	9	patient	patient	NOUN
bjp-20418	51	10	ranging	range	VERB
bjp-20418	51	11	in	in	ADP
bjp-20418	51	12	the	the	DET
bjp-20418	51	13	age	age	NOUN
bjp-20418	51	14	group	group	NOUN
bjp-20418	51	15	of	of	ADP
bjp-20418	51	16	>	>	SYM
bjp-20418	51	17	40	40	NUM
bjp-20418	51	18	years	year	NOUN
bjp-20418	51	19	were	be	AUX
bjp-20418	51	20	included	include	VERB
bjp-20418	51	21	.	.	PUNCT
bjp-20418	52	1	in	in	ADP
bjp-20418	52	2	order	order	NOUN
bjp-20418	52	3	to	to	PART
bjp-20418	52	4	avoid	avoid	VERB
bjp-20418	52	5	any	any	DET
bjp-20418	52	6	sample	sample	NOUN
bjp-20418	52	7	bias	bias	NOUN
bjp-20418	52	8	during	during	ADP
bjp-20418	52	9	statistical	statistical	ADJ
bjp-20418	52	10	analysis	analysis	NOUN
bjp-20418	52	11	it	it	PRON
bjp-20418	52	12	is	be	AUX
bjp-20418	52	13	ensured	ensure	VERB
bjp-20418	52	14	that	that	SCONJ
bjp-20418	52	15	smad	smad	PROPN
bjp-20418	52	16	mutations	mutation	NOUN
bjp-20418	52	17	patient	patient	ADJ
bjp-20418	52	18	populations	population	NOUN
bjp-20418	52	19	alone	alone	ADV
bjp-20418	52	20	were	be	AUX
bjp-20418	52	21	maintained	maintain	VERB
bjp-20418	52	22	less	less	ADJ
bjp-20418	52	23	than	than	ADP
bjp-20418	52	24	20	20	NUM
bjp-20418	52	25	%	%	NOUN
bjp-20418	52	26	of	of	ADP
bjp-20418	52	27	total	total	ADJ
bjp-20418	52	28	population	population	NOUN
bjp-20418	52	29	info	info	NOUN
bjp-20418	52	30	(	(	PUNCT
bjp-20418	52	31	n	n	NOUN
bjp-20418	52	32	=	=	SYM
bjp-20418	52	33	157	157	NUM
bjp-20418	52	34	)	)	PUNCT
bjp-20418	52	35	.	.	PUNCT
bjp-20418	53	1	statistical	statistical	ADJ
bjp-20418	53	2	analysis	analysis	NOUN
bjp-20418	53	3	statistical	statistical	ADJ
bjp-20418	53	4	analyses	analysis	NOUN
bjp-20418	53	5	were	be	AUX
bjp-20418	53	6	performed	perform	VERB
bjp-20418	53	7	using	use	VERB
bjp-20418	53	8	graphpad	graphpad	NOUN
bjp-20418	53	9	prism	prism	NOUN
bjp-20418	53	10	(	(	PUNCT
bjp-20418	53	11	version	version	NOUN
bjp-20418	53	12	6	6	NUM
bjp-20418	53	13	)	)	PUNCT
bjp-20418	53	14	.	.	PUNCT
bjp-20418	54	1	data	datum	NOUN
bjp-20418	54	2	were	be	AUX
bjp-20418	54	3	analyzed	analyze	VERB
bjp-20418	54	4	using	use	VERB
bjp-20418	54	5	one	one	NUM
bjp-20418	54	6	-	-	PUNCT
bjp-20418	54	7	way	way	NOUN
bjp-20418	54	8	anova	anova	X
bjp-20418	54	9	analysis	analysis	NOUN
bjp-20418	54	10	and	and	CCONJ
bjp-20418	54	11	statistical	statistical	ADJ
bjp-20418	54	12	significance	significance	NOUN
bjp-20418	54	13	was	be	AUX
bjp-20418	54	14	set	set	VERB
bjp-20418	54	15	at	at	ADP
bjp-20418	54	16	minimal	minimal	ADJ
bjp-20418	54	17	value	value	NOUN
bjp-20418	54	18	of	of	ADP
bjp-20418	54	19	p<0.05	p<0.05	NOUN
bjp-20418	54	20	.	.	PUNCT
bjp-20418	55	1	all	all	DET
bjp-20418	55	2	values	value	NOUN
bjp-20418	55	3	are	be	AUX
bjp-20418	55	4	listed	list	VERB
bjp-20418	55	5	as	as	ADP
bjp-20418	55	6	mean	mean	NOUN
bjp-20418	55	7	±	±	NUM
bjp-20418	55	8	standard	standard	ADJ
bjp-20418	55	9	deviation	deviation	NOUN
bjp-20418	55	10	.	.	PUNCT
bjp-20418	56	1	results	result	NOUN
bjp-20418	56	2	mtt	mtt	PROPN
bjp-20418	56	3	assay	assay	VERB
bjp-20418	56	4	was	be	AUX
bjp-20418	56	5	performed	perform	VERB
bjp-20418	56	6	for	for	ADP
bjp-20418	56	7	evaluating	evaluate	VERB
bjp-20418	56	8	their	their	PRON
bjp-20418	56	9	cell	cell	NOUN
bjp-20418	56	10	viability	viability	NOUN
bjp-20418	56	11	.	.	PUNCT
bjp-20418	57	1	the	the	DET
bjp-20418	57	2	viability	viability	NOUN
bjp-20418	57	3	of	of	ADP
bjp-20418	57	4	sw620	sw620	PROPN
bjp-20418	57	5	and	and	CCONJ
bjp-20418	57	6	sw480	sw480	PROPN
bjp-20418	57	7	cells	cell	NOUN
bjp-20418	57	8	in	in	ADP
bjp-20418	57	9	curcumin	curcumin	NOUN
bjp-20418	57	10	alone	alone	ADV
bjp-20418	57	11	treated	treat	VERB
bjp-20418	57	12	cells	cell	NOUN
bjp-20418	57	13	was	be	AUX
bjp-20418	57	14	71.1	71.1	NUM
bjp-20418	57	15	and	and	CCONJ
bjp-20418	57	16	69.2	69.2	NUM
bjp-20418	57	17	%	%	NOUN
bjp-20418	57	18	,	,	PUNCT
bjp-20418	57	19	with	with	SCONJ
bjp-20418	57	20	5fu	5fu	NOUN
bjp-20418	57	21	alone	alone	ADJ
bjp-20418	57	22	was	be	AUX
bjp-20418	57	23	67.2	67.2	NUM
bjp-20418	57	24	and	and	CCONJ
bjp-20418	57	25	71	71	NUM
bjp-20418	57	26	%	%	NOUN
bjp-20418	57	27	,	,	PUNCT
bjp-20418	57	28	but	but	CCONJ
bjp-20418	57	29	with	with	ADP
bjp-20418	57	30	the	the	DET
bjp-20418	57	31	combination	combination	NOUN
bjp-20418	57	32	curcumin	curcumin	NOUN
bjp-20418	57	33	–	–	PUNCT
bjp-20418	57	34	5	5	NUM
bjp-20418	57	35	-	-	PUNCT
bjp-20418	57	36	fluorouracil	fluorouracil	NOUN
bjp-20418	57	37	was	be	AUX
bjp-20418	57	38	reduced	reduce	VERB
bjp-20418	57	39	to	to	ADP
bjp-20418	57	40	48.2	48.2	NUM
bjp-20418	57	41	and	and	CCONJ
bjp-20418	57	42	44	44	NUM
bjp-20418	57	43	%	%	NOUN
bjp-20418	57	44	respectively	respectively	ADV
bjp-20418	57	45	(	(	PUNCT
bjp-20418	57	46	figure	figure	NOUN
bjp-20418	57	47	1	1	NUM
bjp-20418	57	48	)	)	PUNCT
bjp-20418	57	49	.	.	PUNCT
bjp-20418	58	1	similarly	similarly	ADV
bjp-20418	58	2	,	,	PUNCT
bjp-20418	58	3	viability	viability	NOUN
bjp-20418	58	4	of	of	ADP
bjp-20418	58	5	fet	fet	PROPN
bjp-20418	58	6	and	and	CCONJ
bjp-20418	58	7	caco2	caco2	NOUN
bjp-20418	58	8	cells	cell	NOUN
bjp-20418	58	9	was	be	AUX
bjp-20418	58	10	41	41	NUM
bjp-20418	58	11	and	and	CCONJ
bjp-20418	58	12	43	43	NUM
bjp-20418	58	13	%	%	NOUN
bjp-20418	58	14	cells	cell	NOUN
bjp-20418	58	15	in	in	ADP
bjp-20418	58	16	curcumin	curcumin	NOUN
bjp-20418	58	17	alone	alone	ADV
bjp-20418	58	18	treated	treat	VERB
bjp-20418	58	19	conditions	condition	NOUN
bjp-20418	58	20	,	,	PUNCT
bjp-20418	58	21	47	47	NUM
bjp-20418	58	22	and	and	CCONJ
bjp-20418	58	23	49	49	NUM
bjp-20418	58	24	%	%	NOUN
bjp-20418	58	25	cells	cell	NOUN
bjp-20418	58	26	in	in	ADP
bjp-20418	58	27	5	5	NUM
bjp-20418	58	28	-	-	PUNCT
bjp-20418	58	29	fluorouracil	fluorouracil	NOUN
bjp-20418	58	30	treated	treat	VERB
bjp-20418	58	31	condition	condition	NOUN
bjp-20418	58	32	,	,	PUNCT
bjp-20418	58	33	and	and	CCONJ
bjp-20418	58	34	23	23	NUM
bjp-20418	58	35	and	and	CCONJ
bjp-20418	58	36	19	19	NUM
bjp-20418	58	37	%	%	NOUN
bjp-20418	58	38	in	in	ADP
bjp-20418	58	39	synergistic	synergistic	ADJ
bjp-20418	58	40	treatment	treatment	NOUN
bjp-20418	58	41	conditions	condition	NOUN
bjp-20418	58	42	.	.	PUNCT
bjp-20418	59	1	these	these	DET
bjp-20418	59	2	results	result	NOUN
bjp-20418	59	3	indicate	indicate	VERB
bjp-20418	59	4	that	that	SCONJ
bjp-20418	59	5	the	the	DET
bjp-20418	59	6	smad	smad	NOUN
bjp-20418	59	7	signaling	signal	VERB
bjp-20418	59	8	responsive	responsive	ADJ
bjp-20418	59	9	cell	cell	NOUN
bjp-20418	59	10	lines	line	NOUN
bjp-20418	59	11	is	be	AUX
bjp-20418	59	12	more	more	ADV
bjp-20418	59	13	sensitive	sensitive	ADJ
bjp-20418	59	14	to	to	ADP
bjp-20418	59	15	drugs	drug	NOUN
bjp-20418	59	16	than	than	ADP
bjp-20418	59	17	smad	smad	PROPN
bjp-20418	59	18	signaling	signal	VERB
bjp-20418	59	19	non	non	ADJ
bjp-20418	59	20	-	-	ADJ
bjp-20418	59	21	responsive	responsive	ADJ
bjp-20418	59	22	cell	cell	NOUN
bjp-20418	59	23	lines	line	NOUN
bjp-20418	59	24	.	.	PUNCT
bjp-20418	60	1	in	in	ADP
bjp-20418	60	2	addition	addition	NOUN
bjp-20418	60	3	,	,	PUNCT
bjp-20418	60	4	the	the	DET
bjp-20418	60	5	drug	drug	NOUN
bjp-20418	60	6	combinations	combination	NOUN
bjp-20418	60	7	could	could	AUX
bjp-20418	60	8	induce	induce	VERB
bjp-20418	60	9	more	more	ADJ
bjp-20418	60	10	cell	cell	NOUN
bjp-20418	60	11	death	death	NOUN
bjp-20418	60	12	than	than	ADP
bjp-20418	60	13	the	the	DET
bjp-20418	60	14	individual	individual	ADJ
bjp-20418	60	15	treatments	treatment	NOUN
bjp-20418	60	16	in	in	ADP
bjp-20418	60	17	all	all	DET
bjp-20418	60	18	the	the	DET
bjp-20418	60	19	540	540	NUM
bjp-20418	60	20	bangladesh	bangladesh	NOUN
bjp-20418	60	21	j	j	PROPN
bjp-20418	60	22	pharmacol	pharmacol	PROPN
bjp-20418	60	23	2014	2014	NUM
bjp-20418	60	24	;	;	PUNCT
bjp-20418	60	25	9	9	NUM
bjp-20418	60	26	:	:	SYM
bjp-20418	60	27	539	539	NUM
bjp-20418	60	28	-	-	SYM
bjp-20418	60	29	544	544	NUM
bjp-20418	60	30	bangladesh	bangladesh	NOUN
bjp-20418	60	31	j	j	PROPN
bjp-20418	60	32	pharmacol	pharmacol	PROPN
bjp-20418	60	33	2014	2014	NUM
bjp-20418	60	34	;	;	PUNCT
bjp-20418	60	35	9	9	NUM
bjp-20418	60	36	:	:	SYM
bjp-20418	60	37	539	539	NUM
bjp-20418	60	38	-	-	SYM
bjp-20418	60	39	544	544	NUM
bjp-20418	60	40	541	541	NUM
bjp-20418	60	41	c	c	NOUN
bjp-20418	60	42	u	u	NOUN
bjp-20418	60	43	r	r	NOUN
bjp-20418	60	44	c	c	NOUN
bjp-20418	60	45	u	u	NOUN
bjp-20418	60	46	m	m	VERB
bjp-20418	60	47	in	in	ADP
bjp-20418	60	48	5	5	NUM
bjp-20418	60	49	f	f	NOUN
bjp-20418	60	50	u	u	NOUN
bjp-20418	60	51	c	c	NOUN
bjp-20418	60	52	u	u	NOUN
bjp-20418	60	53	r	r	NOUN
bjp-20418	60	54	c	c	NOUN
bjp-20418	60	55	u	u	NOUN
bjp-20418	60	56	m	m	VERB
bjp-20418	60	57	in	in	ADP
bjp-20418	60	58	&	&	CCONJ
bjp-20418	60	59	5	5	NUM
bjp-20418	60	60	f	f	PROPN
bjp-20418	60	61	u	u	NOUN
bjp-20418	60	62	c	c	NOUN
bjp-20418	60	63	o	o	X
bjp-20418	60	64	n	n	PRON
bjp-20418	60	65	tr	tr	NOUN
bjp-20418	60	66	o	o	PROPN
bjp-20418	60	67	l	l	NOUN
bjp-20418	60	68	c	c	NOUN
bjp-20418	60	69	u	u	NOUN
bjp-20418	60	70	r	r	NOUN
bjp-20418	60	71	c	c	NOUN
bjp-20418	60	72	u	u	NOUN
bjp-20418	60	73	m	m	VERB
bjp-20418	60	74	in	in	ADP
bjp-20418	60	75	5	5	NUM
bjp-20418	60	76	f	f	NOUN
bjp-20418	60	77	u	u	NOUN
bjp-20418	60	78	c	c	NOUN
bjp-20418	60	79	u	u	NOUN
bjp-20418	60	80	r	r	NOUN
bjp-20418	60	81	c	c	NOUN
bjp-20418	60	82	u	u	NOUN
bjp-20418	60	83	m	m	VERB
bjp-20418	60	84	in	in	ADP
bjp-20418	60	85	&	&	CCONJ
bjp-20418	60	86	5	5	NUM
bjp-20418	60	87	f	f	PROPN
bjp-20418	60	88	u	u	NOUN
bjp-20418	60	89	c	c	NOUN
bjp-20418	60	90	o	o	X
bjp-20418	60	91	n	n	PRON
bjp-20418	60	92	tr	tr	NOUN
bjp-20418	60	93	o	o	PROPN
bjp-20418	60	94	l	l	NOUN
bjp-20418	60	95	c	c	NOUN
bjp-20418	60	96	u	u	NOUN
bjp-20418	60	97	r	r	NOUN
bjp-20418	60	98	c	c	NOUN
bjp-20418	60	99	u	u	NOUN
bjp-20418	60	100	m	m	VERB
bjp-20418	60	101	in	in	ADP
bjp-20418	60	102	5	5	NUM
bjp-20418	60	103	f	f	NOUN
bjp-20418	60	104	u	u	NOUN
bjp-20418	60	105	c	c	NOUN
bjp-20418	60	106	u	u	NOUN
bjp-20418	60	107	r	r	NOUN
bjp-20418	60	108	c	c	NOUN
bjp-20418	60	109	u	u	NOUN
bjp-20418	60	110	m	m	VERB
bjp-20418	60	111	in	in	ADP
bjp-20418	60	112	&	&	CCONJ
bjp-20418	60	113	5	5	NUM
bjp-20418	60	114	f	f	PROPN
bjp-20418	60	115	u	u	NOUN
bjp-20418	60	116	c	c	NOUN
bjp-20418	60	117	o	o	X
bjp-20418	60	118	n	n	PRON
bjp-20418	60	119	tr	tr	NOUN
bjp-20418	60	120	o	o	PROPN
bjp-20418	60	121	l	l	NOUN
bjp-20418	60	122	c	c	NOUN
bjp-20418	60	123	u	u	NOUN
bjp-20418	60	124	r	r	NOUN
bjp-20418	60	125	c	c	NOUN
bjp-20418	60	126	u	u	NOUN
bjp-20418	60	127	m	m	VERB
bjp-20418	60	128	in	in	ADP
bjp-20418	60	129	5	5	NUM
bjp-20418	60	130	f	f	NOUN
bjp-20418	60	131	u	u	NOUN
bjp-20418	60	132	c	c	NOUN
bjp-20418	60	133	u	u	NOUN
bjp-20418	60	134	r	r	NOUN
bjp-20418	60	135	c	c	NOUN
bjp-20418	60	136	u	u	NOUN
bjp-20418	60	137	m	m	VERB
bjp-20418	60	138	in	in	ADP
bjp-20418	60	139	&	&	CCONJ
bjp-20418	60	140	5	5	NUM
bjp-20418	60	141	f	f	PROPN
bjp-20418	60	142	u	u	NOUN
bjp-20418	60	143	c	c	NOUN
bjp-20418	60	144	o	o	X
bjp-20418	60	145	n	n	PRON
bjp-20418	60	146	tr	tr	NOUN
bjp-20418	60	147	o	o	PROPN
bjp-20418	60	148	l	l	NOUN
bjp-20418	60	149	0	0	NUM
bjp-20418	60	150	2	2	NUM
bjp-20418	60	151	0	0	NUM
bjp-20418	60	152	4	4	NUM
bjp-20418	60	153	0	0	NUM
bjp-20418	60	154	6	6	NUM
bjp-20418	60	155	0	0	NUM
bjp-20418	60	156	8	8	NUM
bjp-20418	60	157	0	0	NUM
bjp-20418	60	158	1	1	NUM
bjp-20418	60	159	0	0	NUM
bjp-20418	60	160	0	0	NUM
bjp-20418	60	161	c	c	NOUN
bjp-20418	60	162	u	u	PROPN
bjp-20418	60	163	rc	rc	PROPN
bjp-20418	60	164	u	u	NOUN
bjp-20418	60	165	m	m	VERB
bjp-20418	60	166	in	in	ADP
bjp-20418	60	167	5	5	NUM
bjp-20418	60	168	f	f	NOUN
bjp-20418	60	169	u	u	NOUN
bjp-20418	60	170	c	c	PROPN
bjp-20418	60	171	u	u	NOUN
bjp-20418	60	172	rc	rc	PROPN
bjp-20418	60	173	u	u	NOUN
bjp-20418	60	174	m	m	VERB
bjp-20418	60	175	in	in	ADP
bjp-20418	60	176	&	&	CCONJ
bjp-20418	60	177	5	5	NUM
bjp-20418	60	178	f	f	PROPN
bjp-20418	60	179	u	u	NOUN
bjp-20418	60	180	c	c	NOUN
bjp-20418	60	181	o	o	NOUN
bjp-20418	60	182	n	n	X
bjp-20418	60	183	tro	tro	X
bjp-20418	60	184	l	l	X
bjp-20418	60	185	s	s	PROPN
bjp-20418	60	186	w	w	PROPN
bjp-20418	60	187	6	6	NUM
bjp-20418	60	188	2	2	NUM
bjp-20418	60	189	0	0	NUM
bjp-20418	60	190	s	s	NOUN
bjp-20418	60	191	w	w	PROPN
bjp-20418	60	192	4	4	NUM
bjp-20418	60	193	8	8	NUM
bjp-20418	60	194	0	0	NUM
bjp-20418	60	195	f	f	NOUN
bjp-20418	60	196	e	e	PROPN
bjp-20418	60	197	t	t	PROPN
bjp-20418	60	198	-1	-1	PROPN
bjp-20418	60	199	c	c	PROPN
bjp-20418	60	200	a	a	DET
bjp-20418	60	201	c	c	NOUN
bjp-20418	60	202	o	o	NOUN
bjp-20418	60	203	2	2	NUM
bjp-20418	60	204	*	*	PUNCT
bjp-20418	60	205	*	*	PUNCT
bjp-20418	61	1	*	*	PUNCT
bjp-20418	61	2	*	*	PUNCT
bjp-20418	61	3	p	p	X
bjp-20418	61	4	e	e	NOUN
bjp-20418	61	5	r	r	NOUN
bjp-20418	61	6	c	c	NOUN
bjp-20418	61	7	e	e	X
bjp-20418	61	8	n	n	NOUN
bjp-20418	61	9	t	t	NOUN
bjp-20418	61	10	c	c	NOUN
bjp-20418	61	11	e	e	X
bjp-20418	61	12	ll	ll	AUX
bjp-20418	61	13	v	v	PROPN
bjp-20418	61	14	ia	ia	PROPN
bjp-20418	61	15	b	b	AUX
bjp-20418	61	16	il	il	PROPN
bjp-20418	61	17	it	it	PRON
bjp-20418	61	18	y	y	PROPN
bjp-20418	61	19	figure	figure	VERB
bjp-20418	61	20	1	1	NUM
bjp-20418	61	21	:	:	PUNCT
bjp-20418	61	22	evaluation	evaluation	NOUN
bjp-20418	61	23	of	of	ADP
bjp-20418	61	24	cell	cell	NOUN
bjp-20418	61	25	viability	viability	NOUN
bjp-20418	61	26	by	by	ADP
bjp-20418	61	27	mtt	mtt	PROPN
bjp-20418	61	28	assay	assay	NOUN
bjp-20418	61	29	mtt	mtt	NOUN
bjp-20418	61	30	assay	assay	VERB
bjp-20418	61	31	showing	show	VERB
bjp-20418	61	32	the	the	DET
bjp-20418	61	33	effect	effect	NOUN
bjp-20418	61	34	of	of	ADP
bjp-20418	61	35	drug	drug	NOUN
bjp-20418	61	36	treatments	treatment	NOUN
bjp-20418	61	37	on	on	ADP
bjp-20418	61	38	viability	viability	NOUN
bjp-20418	61	39	of	of	ADP
bjp-20418	61	40	cells	cell	NOUN
bjp-20418	61	41	.	.	PUNCT
bjp-20418	62	1	cells	cell	NOUN
bjp-20418	62	2	were	be	AUX
bjp-20418	62	3	treated	treat	VERB
bjp-20418	62	4	with	with	ADP
bjp-20418	62	5	individual	individual	ADJ
bjp-20418	62	6	drug	drug	NOUN
bjp-20418	62	7	treatments	treatment	NOUN
bjp-20418	62	8	or	or	CCONJ
bjp-20418	62	9	combinations	combination	NOUN
bjp-20418	62	10	for	for	ADP
bjp-20418	62	11	24	24	NUM
bjp-20418	62	12	hours	hour	NOUN
bjp-20418	62	13	.	.	PUNCT
bjp-20418	63	1	each	each	DET
bjp-20418	63	2	point	point	NOUN
bjp-20418	63	3	value	value	NOUN
bjp-20418	63	4	represents	represent	VERB
bjp-20418	63	5	a	a	DET
bjp-20418	63	6	mean	mean	ADJ
bjp-20418	63	7	value	value	NOUN
bjp-20418	63	8	from	from	ADP
bjp-20418	63	9	three	three	NUM
bjp-20418	63	10	independent	independent	ADJ
bjp-20418	63	11	experiments	experiment	NOUN
bjp-20418	63	12	and	and	CCONJ
bjp-20418	63	13	represents	represent	VERB
bjp-20418	63	14	a	a	DET
bjp-20418	63	15	percent	percent	NOUN
bjp-20418	63	16	viability	viability	NOUN
bjp-20418	63	17	of	of	ADP
bjp-20418	63	18	cells	cell	NOUN
bjp-20418	63	19	remaining	remain	VERB
bjp-20418	63	20	after	after	ADP
bjp-20418	63	21	drug	drug	NOUN
bjp-20418	63	22	treatments	treatment	NOUN
bjp-20418	63	23	.	.	PUNCT
bjp-20418	64	1	smad	smad	PROPN
bjp-20418	64	2	responsive	responsive	ADJ
bjp-20418	64	3	cells	cell	NOUN
bjp-20418	64	4	(	(	PUNCT
bjp-20418	64	5	fet-1	fet-1	NUM
bjp-20418	64	6	and	and	CCONJ
bjp-20418	64	7	caco2	caco2	NOUN
bjp-20418	64	8	)	)	PUNCT
bjp-20418	64	9	showed	show	VERB
bjp-20418	64	10	more	more	ADJ
bjp-20418	64	11	response	response	NOUN
bjp-20418	64	12	in	in	ADP
bjp-20418	64	13	general	general	ADJ
bjp-20418	64	14	and	and	CCONJ
bjp-20418	64	15	further	far	ADV
bjp-20418	64	16	augmented	augment	VERB
bjp-20418	64	17	in	in	ADP
bjp-20418	64	18	combination	combination	NOUN
bjp-20418	64	19	treatments	treatment	NOUN
bjp-20418	64	20	.	.	PUNCT
bjp-20418	65	1	statistical	statistical	ADJ
bjp-20418	65	2	significance	significance	NOUN
bjp-20418	65	3	was	be	AUX
bjp-20418	65	4	seen	see	VERB
bjp-20418	65	5	as	as	ADP
bjp-20418	65	6	(	(	PUNCT
bjp-20418	65	7	*	*	NOUN
bjp-20418	65	8	p<0.01	p<0.01	PROPN
bjp-20418	65	9	)	)	PUNCT
bjp-20418	65	10	between	between	ADP
bjp-20418	65	11	individual	individual	ADJ
bjp-20418	65	12	drug	drug	NOUN
bjp-20418	65	13	treatments	treatment	NOUN
bjp-20418	65	14	and	and	CCONJ
bjp-20418	65	15	combinations	combination	NOUN
bjp-20418	65	16	figure	figure	NOUN
bjp-20418	65	17	2	2	NUM
bjp-20418	65	18	:	:	PUNCT
bjp-20418	65	19	morphological	morphological	ADJ
bjp-20418	65	20	characteristics	characteristic	NOUN
bjp-20418	65	21	of	of	ADP
bjp-20418	65	22	cell	cell	NOUN
bjp-20418	65	23	death	death	NOUN
bjp-20418	65	24	in	in	ADP
bjp-20418	65	25	drug	drug	NOUN
bjp-20418	65	26	induced	induce	VERB
bjp-20418	65	27	apoptosis	apoptosis	NOUN
bjp-20418	65	28	cells	cell	NOUN
bjp-20418	65	29	were	be	AUX
bjp-20418	65	30	treated	treat	VERB
bjp-20418	65	31	with	with	ADP
bjp-20418	65	32	drugs	drug	NOUN
bjp-20418	65	33	and	and	CCONJ
bjp-20418	65	34	were	be	AUX
bjp-20418	65	35	evaluated	evaluate	VERB
bjp-20418	65	36	for	for	ADP
bjp-20418	65	37	apoptosis	apoptosis	NOUN
bjp-20418	65	38	using	use	VERB
bjp-20418	65	39	et	et	NOUN
bjp-20418	65	40	-	-	PUNCT
bjp-20418	65	41	br	br	NOUN
bjp-20418	65	42	/	/	SYM
bjp-20418	65	43	ao	ao	NOUN
bjp-20418	65	44	staining	stain	VERB
bjp-20418	65	45	in	in	ADP
bjp-20418	65	46	all	all	DET
bjp-20418	65	47	four	four	NUM
bjp-20418	65	48	cells	cell	NOUN
bjp-20418	65	49	(	(	PUNCT
bjp-20418	65	50	greenlive	greenlive	ADJ
bjp-20418	65	51	cells	cell	NOUN
bjp-20418	65	52	;	;	PUNCT
bjp-20418	65	53	orange	orange	ADJ
bjp-20418	65	54	/	/	SYM
bjp-20418	65	55	reddead	reddead	NOUN
bjp-20418	65	56	cells	cell	NOUN
bjp-20418	65	57	)	)	PUNCT
bjp-20418	65	58	.	.	PUNCT
bjp-20418	66	1	increased	increase	VERB
bjp-20418	66	2	apoptosis	apoptosis	NOUN
bjp-20418	66	3	were	be	AUX
bjp-20418	66	4	observed	observe	VERB
bjp-20418	66	5	in	in	ADP
bjp-20418	66	6	smad	smad	PROPN
bjp-20418	66	7	responsive	responsive	ADJ
bjp-20418	66	8	cells	cell	NOUN
bjp-20418	66	9	(	(	PUNCT
bjp-20418	66	10	fet-1	fet-1	NUM
bjp-20418	66	11	and	and	CCONJ
bjp-20418	66	12	caco2	caco2	NOUN
bjp-20418	66	13	)	)	PUNCT
bjp-20418	66	14	both	both	CCONJ
bjp-20418	66	15	in	in	ADP
bjp-20418	66	16	individual	individual	ADJ
bjp-20418	66	17	and	and	CCONJ
bjp-20418	66	18	combination	combination	NOUN
bjp-20418	66	19	treatments	treatment	NOUN
bjp-20418	66	20	than	than	ADP
bjp-20418	66	21	in	in	ADP
bjp-20418	66	22	smad	smad	PROPN
bjp-20418	66	23	non	non	ADJ
bjp-20418	66	24	-	-	ADJ
bjp-20418	66	25	responsive	responsive	ADJ
bjp-20418	66	26	cells	cell	NOUN
bjp-20418	66	27	(	(	PUNCT
bjp-20418	66	28	sw620	sw620	ADJ
bjp-20418	66	29	and	and	CCONJ
bjp-20418	66	30	sw480	sw480	PROPN
bjp-20418	66	31	)	)	PUNCT
bjp-20418	66	32	.	.	PUNCT
bjp-20418	67	1	inlet	inlet	VERB
bjp-20418	67	2	numerical	numerical	ADJ
bjp-20418	67	3	value	value	NOUN
bjp-20418	67	4	represents	represent	VERB
bjp-20418	67	5	the	the	DET
bjp-20418	67	6	mean	mean	ADJ
bjp-20418	67	7	percentage	percentage	NOUN
bjp-20418	67	8	of	of	ADP
bjp-20418	67	9	orange	orange	ADJ
bjp-20418	67	10	/	/	SYM
bjp-20418	67	11	red	red	ADJ
bjp-20418	67	12	cells	cell	NOUN
bjp-20418	67	13	(	(	PUNCT
bjp-20418	67	14	apoptotic	apoptotic	ADJ
bjp-20418	67	15	cells	cell	NOUN
bjp-20418	67	16	)	)	PUNCT
bjp-20418	67	17	observe	observe	VERB
bjp-20418	67	18	in	in	ADP
bjp-20418	67	19	synergistic	synergistic	ADJ
bjp-20418	67	20	drug	drug	NOUN
bjp-20418	67	21	treatments	treatment	NOUN
bjp-20418	67	22	of	of	ADP
bjp-20418	67	23	5fu	5fu	NOUN
bjp-20418	67	24	and	and	CCONJ
bjp-20418	67	25	curcumin	curcumin	NOUN
bjp-20418	67	26	from	from	ADP
bjp-20418	67	27	three	three	NUM
bjp-20418	67	28	independent	independent	ADJ
bjp-20418	67	29	experiments	experiment	NOUN
bjp-20418	67	30	.	.	PUNCT
bjp-20418	68	1	scale	scale	NOUN
bjp-20418	68	2	bar	bar	NOUN
bjp-20418	68	3	25	25	NUM
bjp-20418	68	4	mm	mm	NOUN
bjp-20418	68	5	.	.	PUNCT
bjp-20418	68	6	cell	cell	NOUN
bjp-20418	68	7	lines	line	NOUN
bjp-20418	68	8	,	,	PUNCT
bjp-20418	68	9	but	but	CCONJ
bjp-20418	68	10	more	more	ADV
bjp-20418	68	11	prominently	prominently	ADV
bjp-20418	68	12	in	in	ADP
bjp-20418	68	13	smad	smad	PROPN
bjp-20418	68	14	responsive	responsive	ADJ
bjp-20418	68	15	cell	cell	NOUN
bjp-20418	68	16	lines	line	NOUN
bjp-20418	68	17	.	.	PUNCT
bjp-20418	69	1	ethidium	ethidium	ADJ
bjp-20418	69	2	bromide	bromide	NOUN
bjp-20418	69	3	/	/	SYM
bjp-20418	69	4	acridine	acridine	PROPN
bjp-20418	69	5	orange	orange	PROPN
bjp-20418	69	6	(	(	PUNCT
bjp-20418	69	7	et	et	NOUN
bjp-20418	69	8	-	-	PUNCT
bjp-20418	69	9	br	br	NOUN
bjp-20418	69	10	/	/	SYM
bjp-20418	69	11	ao	ao	NOUN
bjp-20418	69	12	)	)	PUNCT
bjp-20418	69	13	staining	stain	VERB
bjp-20418	69	14	was	be	AUX
bjp-20418	69	15	done	do	VERB
bjp-20418	69	16	to	to	PART
bjp-20418	69	17	investigate	investigate	VERB
bjp-20418	69	18	the	the	DET
bjp-20418	69	19	quantitative	quantitative	ADJ
bjp-20418	69	20	and	and	CCONJ
bjp-20418	69	21	qualitative	qualitative	ADJ
bjp-20418	69	22	changes	change	NOUN
bjp-20418	69	23	in	in	ADP
bjp-20418	69	24	nuclear	nuclear	ADJ
bjp-20418	69	25	condensation	condensation	NOUN
bjp-20418	69	26	/	/	SYM
bjp-20418	69	27	apoptosis	apoptosis	NOUN
bjp-20418	69	28	.	.	PUNCT
bjp-20418	70	1	the	the	DET
bjp-20418	70	2	untreated	untreated	ADJ
bjp-20418	70	3	cells	cell	NOUN
bjp-20418	70	4	showed	show	VERB
bjp-20418	70	5	green	green	ADJ
bjp-20418	70	6	color	color	NOUN
bjp-20418	70	7	,	,	PUNCT
bjp-20418	70	8	representing	represent	VERB
bjp-20418	70	9	normal	normal	ADJ
bjp-20418	70	10	cells	cell	NOUN
bjp-20418	70	11	.	.	PUNCT
bjp-20418	71	1	at	at	ADP
bjp-20418	71	2	5	5	NUM
bjp-20418	71	3	µm	µm	ADP
bjp-20418	71	4	concentration	concentration	NOUN
bjp-20418	71	5	of	of	ADP
bjp-20418	71	6	curcumin	curcumin	NOUN
bjp-20418	71	7	and	and	CCONJ
bjp-20418	71	8	5fluorouracil	5fluorouracil	NUM
bjp-20418	71	9	treatment	treatment	NOUN
bjp-20418	71	10	on	on	ADP
bjp-20418	71	11	all	all	DET
bjp-20418	71	12	cell	cell	NOUN
bjp-20418	71	13	lines	line	NOUN
bjp-20418	71	14	,	,	PUNCT
bjp-20418	71	15	orange	orange	ADJ
bjp-20418	71	16	colored	colored	ADJ
bjp-20418	71	17	cells	cell	NOUN
bjp-20418	71	18	indicating	indicate	VERB
bjp-20418	71	19	dna	dna	PROPN
bjp-20418	71	20	damage	damage	NOUN
bjp-20418	71	21	was	be	AUX
bjp-20418	71	22	observed	observe	VERB
bjp-20418	71	23	.	.	PUNCT
bjp-20418	72	1	cell	cell	NOUN
bjp-20418	72	2	shrinkage	shrinkage	NOUN
bjp-20418	72	3	and	and	CCONJ
bjp-20418	72	4	nuclear	nuclear	ADJ
bjp-20418	72	5	condensation	condensation	NOUN
bjp-20418	72	6	(	(	PUNCT
bjp-20418	72	7	smaller	small	ADJ
bjp-20418	72	8	nuclei	nucleus	NOUN
bjp-20418	72	9	)	)	PUNCT
bjp-20418	72	10	were	be	AUX
bjp-20418	72	11	observed	observe	VERB
bjp-20418	72	12	after	after	ADP
bjp-20418	72	13	treatments	treatment	NOUN
bjp-20418	72	14	.	.	PUNCT
bjp-20418	73	1	however	however	ADV
bjp-20418	73	2	,	,	PUNCT
bjp-20418	73	3	there	there	PRON
bjp-20418	73	4	were	be	VERB
bjp-20418	73	5	only	only	ADV
bjp-20418	73	6	a	a	DET
bjp-20418	73	7	few	few	ADJ
bjp-20418	73	8	percentages	percentage	NOUN
bjp-20418	73	9	of	of	ADP
bjp-20418	73	10	cells	cell	NOUN
bjp-20418	73	11	(	(	PUNCT
bjp-20418	73	12	~20	~20	NOUN
bjp-20418	73	13	-	-	SYM
bjp-20418	73	14	30	30	NUM
bjp-20418	73	15	%	%	NOUN
bjp-20418	73	16	)	)	PUNCT
bjp-20418	73	17	showed	show	VERB
bjp-20418	73	18	these	these	DET
bjp-20418	73	19	features	feature	NOUN
bjp-20418	73	20	in	in	ADP
bjp-20418	73	21	individual	individual	ADJ
bjp-20418	73	22	treatments	treatment	NOUN
bjp-20418	73	23	in	in	ADP
bjp-20418	73	24	fet-1	fet-1	PUNCT
bjp-20418	73	25	and	and	CCONJ
bjp-20418	73	26	caco2	caco2	NOUN
bjp-20418	73	27	cells	cell	NOUN
bjp-20418	73	28	and	and	CCONJ
bjp-20418	73	29	were	be	AUX
bjp-20418	73	30	minimal	minimal	ADJ
bjp-20418	73	31	in	in	ADP
bjp-20418	73	32	sw620	sw620	ADJ
bjp-20418	73	33	and	and	CCONJ
bjp-20418	74	1	sw480	sw480	PROPN
bjp-20418	74	2	cells	cell	NOUN
bjp-20418	74	3	(	(	PUNCT
bjp-20418	74	4	<	<	X
bjp-20418	74	5	20	20	NUM
bjp-20418	74	6	%	%	NOUN
bjp-20418	74	7	)	)	PUNCT
bjp-20418	74	8	.	.	PUNCT
bjp-20418	75	1	in	in	ADP
bjp-20418	75	2	summary	summary	NOUN
bjp-20418	75	3	,	,	PUNCT
bjp-20418	75	4	individual	individual	ADJ
bjp-20418	75	5	treatments	treatment	NOUN
bjp-20418	75	6	showed	show	VERB
bjp-20418	75	7	figure	figure	NOUN
bjp-20418	75	8	4	4	NUM
bjp-20418	75	9	:	:	PUNCT
bjp-20418	75	10	overexpression	overexpression	NOUN
bjp-20418	75	11	of	of	ADP
bjp-20418	75	12	smad4	smad4	NOUN
bjp-20418	75	13	and	and	CCONJ
bjp-20418	75	14	improved	improve	VERB
bjp-20418	75	15	drug	drug	NOUN
bjp-20418	75	16	response	response	NOUN
bjp-20418	75	17	smad4	smad4	NOUN
bjp-20418	75	18	overexpressing	overexpresse	VERB
bjp-20418	75	19	cells	cell	NOUN
bjp-20418	75	20	were	be	AUX
bjp-20418	75	21	treated	treat	VERB
bjp-20418	75	22	with	with	ADP
bjp-20418	75	23	drugs	drug	NOUN
bjp-20418	75	24	and	and	CCONJ
bjp-20418	75	25	cell	cell	NOUN
bjp-20418	75	26	viability	viability	NOUN
bjp-20418	75	27	was	be	AUX
bjp-20418	75	28	evaluated	evaluate	VERB
bjp-20418	75	29	by	by	ADP
bjp-20418	75	30	mtt	mtt	NOUN
bjp-20418	75	31	assay	assay	NOUN
bjp-20418	75	32	.	.	PUNCT
bjp-20418	76	1	each	each	DET
bjp-20418	76	2	point	point	NOUN
bjp-20418	76	3	value	value	NOUN
bjp-20418	76	4	represents	represent	VERB
bjp-20418	76	5	a	a	DET
bjp-20418	76	6	mean	mean	ADJ
bjp-20418	76	7	value	value	NOUN
bjp-20418	76	8	from	from	ADP
bjp-20418	76	9	three	three	NUM
bjp-20418	76	10	independent	independent	ADJ
bjp-20418	76	11	experiments	experiment	NOUN
bjp-20418	76	12	and	and	CCONJ
bjp-20418	76	13	represents	represent	VERB
bjp-20418	76	14	a	a	DET
bjp-20418	76	15	percent	percent	NOUN
bjp-20418	76	16	viability	viability	NOUN
bjp-20418	76	17	of	of	ADP
bjp-20418	76	18	cells	cell	NOUN
bjp-20418	76	19	remaining	remain	VERB
bjp-20418	76	20	after	after	ADP
bjp-20418	76	21	drug	drug	NOUN
bjp-20418	76	22	treatments	treatment	NOUN
bjp-20418	76	23	.	.	PUNCT
bjp-20418	77	1	smad	smad	PROPN
bjp-20418	77	2	non	non	ADJ
bjp-20418	77	3	-	-	ADJ
bjp-20418	77	4	responsive	responsive	ADJ
bjp-20418	77	5	cells	cell	NOUN
bjp-20418	77	6	sw620	sw620	ADJ
bjp-20418	78	1	and	and	CCONJ
bjp-20418	78	2	sw480	sw480	PROPN
bjp-20418	78	3	that	that	PRON
bjp-20418	78	4	are	be	AUX
bjp-20418	78	5	previously	previously	ADV
bjp-20418	78	6	less	less	ADV
bjp-20418	78	7	prone	prone	ADJ
bjp-20418	78	8	to	to	ADP
bjp-20418	78	9	apoptosis	apoptosis	NOUN
bjp-20418	78	10	now	now	ADV
bjp-20418	78	11	exhibited	exhibit	VERB
bjp-20418	78	12	increased	increase	VERB
bjp-20418	78	13	apoptosis	apoptosis	NOUN
bjp-20418	78	14	.	.	PUNCT
bjp-20418	79	1	a	a	DET
bjp-20418	79	2	similar	similar	ADJ
bjp-20418	79	3	trend	trend	NOUN
bjp-20418	79	4	of	of	ADP
bjp-20418	79	5	increased	increase	VERB
bjp-20418	79	6	apoptosis	apoptosis	NOUN
bjp-20418	79	7	were	be	AUX
bjp-20418	79	8	seen	see	VERB
bjp-20418	79	9	in	in	ADP
bjp-20418	79	10	other	other	ADJ
bjp-20418	79	11	cells	cell	NOUN
bjp-20418	79	12	(	(	PUNCT
bjp-20418	79	13	fet-1	fet-1	NUM
bjp-20418	79	14	and	and	CCONJ
bjp-20418	79	15	caco2	caco2	NOUN
bjp-20418	79	16	)	)	PUNCT
bjp-20418	79	17	as	as	ADV
bjp-20418	79	18	well	well	ADV
bjp-20418	79	19	upon	upon	SCONJ
bjp-20418	79	20	overexpressing	overexpresse	VERB
bjp-20418	79	21	smad4	smad4	NOUN
bjp-20418	79	22	in	in	ADP
bjp-20418	79	23	them	they	PRON
bjp-20418	79	24	.	.	PUNCT
bjp-20418	80	1	statistical	statistical	ADJ
bjp-20418	80	2	significance	significance	NOUN
bjp-20418	80	3	was	be	AUX
bjp-20418	80	4	seen	see	VERB
bjp-20418	80	5	as	as	ADP
bjp-20418	80	6	(	(	PUNCT
bjp-20418	80	7	*	*	NOUN
bjp-20418	80	8	p<0.01	p<0.01	PROPN
bjp-20418	80	9	)	)	PUNCT
bjp-20418	80	10	between	between	ADP
bjp-20418	80	11	individual	individual	ADJ
bjp-20418	80	12	drug	drug	NOUN
bjp-20418	80	13	treatments	treatment	NOUN
bjp-20418	80	14	and	and	CCONJ
bjp-20418	80	15	combinations	combination	NOUN
bjp-20418	80	16	of	of	ADP
bjp-20418	80	17	only	only	ADV
bjp-20418	80	18	sw620	sw620	ADJ
bjp-20418	80	19	and	and	CCONJ
bjp-20418	80	20	sw480	sw480	ADP
bjp-20418	80	21	cells	cell	NOUN
bjp-20418	80	22	alone	alone	ADJ
bjp-20418	80	23	as	as	SCONJ
bjp-20418	80	24	there	there	PRON
bjp-20418	80	25	were	be	VERB
bjp-20418	80	26	only	only	ADV
bjp-20418	80	27	few	few	ADJ
bjp-20418	80	28	cell	cell	NOUN
bjp-20418	80	29	viability	viability	NOUN
bjp-20418	80	30	in	in	ADP
bjp-20418	80	31	any	any	PRON
bjp-20418	80	32	of	of	ADP
bjp-20418	80	33	the	the	DET
bjp-20418	80	34	treatments	treatment	NOUN
bjp-20418	80	35	in	in	ADP
bjp-20418	80	36	fet-1	fet-1	PUNCT
bjp-20418	80	37	and	and	CCONJ
bjp-20418	80	38	caco2	caco2	NOUN
bjp-20418	80	39	cells	cell	NOUN
bjp-20418	80	40	542	542	NUM
bjp-20418	80	41	bangladesh	bangladesh	PROPN
bjp-20418	80	42	j	j	PROPN
bjp-20418	80	43	pharmacol	pharmacol	PROPN
bjp-20418	80	44	2014	2014	NUM
bjp-20418	80	45	;	;	PUNCT
bjp-20418	80	46	9	9	NUM
bjp-20418	80	47	:	:	SYM
bjp-20418	80	48	539	539	NUM
bjp-20418	80	49	-	-	SYM
bjp-20418	80	50	544	544	NUM
bjp-20418	80	51	figure	figure	NOUN
bjp-20418	80	52	3	3	NUM
bjp-20418	80	53	:	:	PUNCT
bjp-20418	80	54	evaluation	evaluation	NOUN
bjp-20418	80	55	of	of	ADP
bjp-20418	80	56	smad	smad	ADJ
bjp-20418	80	57	proteins	protein	NOUN
bjp-20418	80	58	in	in	ADP
bjp-20418	80	59	drug	drug	NOUN
bjp-20418	80	60	induced	induce	VERB
bjp-20418	80	61	apoptosis	apoptosis	NOUN
bjp-20418	80	62	cells	cell	NOUN
bjp-20418	80	63	were	be	AUX
bjp-20418	80	64	treated	treat	VERB
bjp-20418	80	65	with	with	ADP
bjp-20418	80	66	drugs	drug	NOUN
bjp-20418	80	67	and	and	CCONJ
bjp-20418	80	68	were	be	AUX
bjp-20418	80	69	evaluated	evaluate	VERB
bjp-20418	80	70	for	for	ADP
bjp-20418	80	71	smad	smad	PROPN
bjp-20418	80	72	4	4	NUM
bjp-20418	80	73	protein	protein	NOUN
bjp-20418	80	74	levels	level	NOUN
bjp-20418	80	75	.	.	PUNCT
bjp-20418	81	1	smad4	smad4	NOUN
bjp-20418	81	2	levels	level	NOUN
bjp-20418	81	3	were	be	AUX
bjp-20418	81	4	increased	increase	VERB
bjp-20418	81	5	in	in	ADP
bjp-20418	81	6	fet-1	fet-1	PUNCT
bjp-20418	81	7	and	and	CCONJ
bjp-20418	81	8	caco2	caco2	NOUN
bjp-20418	81	9	cells	cell	NOUN
bjp-20418	81	10	(	(	PUNCT
bjp-20418	81	11	>	>	X
bjp-20418	81	12	3	3	NUM
bjp-20418	81	13	-	-	NUM
bjp-20418	81	14	fold	fold	ADJ
bjp-20418	81	15	)	)	PUNCT
bjp-20418	81	16	.	.	PUNCT
bjp-20418	82	1	beta	beta	NOUN
bjp-20418	82	2	-	-	PUNCT
bjp-20418	82	3	actin	actin	NOUN
bjp-20418	82	4	was	be	AUX
bjp-20418	82	5	used	use	VERB
bjp-20418	82	6	as	as	ADP
bjp-20418	82	7	a	a	DET
bjp-20418	82	8	loading	loading	NOUN
bjp-20418	82	9	control	control	NOUN
bjp-20418	82	10	0	0	NUM
bjp-20418	82	11	2	2	NUM
bjp-20418	82	12	0	0	NUM
bjp-20418	82	13	4	4	NUM
bjp-20418	82	14	0	0	NUM
bjp-20418	82	15	6	6	NUM
bjp-20418	82	16	0	0	NUM
bjp-20418	82	17	8	8	NUM
bjp-20418	82	18	0	0	NUM
bjp-20418	82	19	1	1	NUM
bjp-20418	82	20	0	0	NUM
bjp-20418	82	21	0	0	NUM
bjp-20418	82	22	c	c	NOUN
bjp-20418	82	23	u	u	PROPN
bjp-20418	82	24	rc	rc	PROPN
bjp-20418	82	25	u	u	NOUN
bjp-20418	82	26	m	m	VERB
bjp-20418	82	27	in	in	ADP
bjp-20418	82	28	5	5	NUM
bjp-20418	82	29	f	f	NOUN
bjp-20418	82	30	u	u	NOUN
bjp-20418	82	31	c	c	PROPN
bjp-20418	82	32	u	u	NOUN
bjp-20418	82	33	rc	rc	PROPN
bjp-20418	82	34	u	u	NOUN
bjp-20418	82	35	m	m	VERB
bjp-20418	82	36	in	in	ADP
bjp-20418	82	37	&	&	CCONJ
bjp-20418	82	38	5	5	NUM
bjp-20418	82	39	f	f	PROPN
bjp-20418	82	40	u	u	NOUN
bjp-20418	82	41	c	c	NOUN
bjp-20418	82	42	o	o	NOUN
bjp-20418	82	43	n	n	X
bjp-20418	82	44	tro	tro	X
bjp-20418	82	45	l	l	X
bjp-20418	82	46	s	s	PROPN
bjp-20418	82	47	w	w	PROPN
bjp-20418	82	48	6	6	NUM
bjp-20418	82	49	2	2	NUM
bjp-20418	82	50	0	0	NUM
bjp-20418	82	51	s	s	NOUN
bjp-20418	82	52	w	w	PROPN
bjp-20418	82	53	4	4	NUM
bjp-20418	82	54	8	8	NUM
bjp-20418	82	55	0	0	NUM
bjp-20418	82	56	f	f	NOUN
bjp-20418	82	57	e	e	PROPN
bjp-20418	82	58	t	t	PROPN
bjp-20418	82	59	-1	-1	PROPN
bjp-20418	82	60	c	c	PROPN
bjp-20418	83	1	a	a	DET
bjp-20418	83	2	c	c	NOUN
bjp-20418	83	3	o	o	NOUN
bjp-20418	83	4	2	2	NUM
bjp-20418	83	5	p	p	NOUN
bjp-20418	83	6	e	e	NOUN
bjp-20418	83	7	r	r	NOUN
bjp-20418	83	8	c	c	NOUN
bjp-20418	83	9	e	e	X
bjp-20418	83	10	n	n	NOUN
bjp-20418	83	11	t	t	NOUN
bjp-20418	83	12	c	c	NOUN
bjp-20418	83	13	e	e	X
bjp-20418	83	14	ll	ll	AUX
bjp-20418	83	15	v	v	PROPN
bjp-20418	83	16	ia	ia	PROPN
bjp-20418	83	17	b	b	PROPN
bjp-20418	83	18	il	il	PROPN
bjp-20418	83	19	it	it	PRON
bjp-20418	83	20	y	y	NOUN
bjp-20418	83	21	c	c	NOUN
bjp-20418	83	22	u	u	NOUN
bjp-20418	83	23	r	r	NOUN
bjp-20418	83	24	c	c	NOUN
bjp-20418	83	25	u	u	NOUN
bjp-20418	83	26	m	m	VERB
bjp-20418	83	27	in	in	ADP
bjp-20418	83	28	c	c	NOUN
bjp-20418	83	29	u	u	NOUN
bjp-20418	83	30	r	r	NOUN
bjp-20418	83	31	c	c	NOUN
bjp-20418	83	32	u	u	NOUN
bjp-20418	83	33	m	m	VERB
bjp-20418	83	34	in	in	ADP
bjp-20418	83	35	c	c	NOUN
bjp-20418	83	36	u	u	NOUN
bjp-20418	84	1	r	r	NOUN
bjp-20418	84	2	c	c	NOUN
bjp-20418	84	3	u	u	NOUN
bjp-20418	84	4	m	m	VERB
bjp-20418	84	5	in	in	ADP
bjp-20418	84	6	c	c	NOUN
bjp-20418	84	7	u	u	NOUN
bjp-20418	84	8	r	r	NOUN
bjp-20418	84	9	c	c	NOUN
bjp-20418	84	10	u	u	NOUN
bjp-20418	84	11	m	m	VERB
bjp-20418	84	12	in	in	ADP
bjp-20418	84	13	5	5	NUM
bjp-20418	84	14	f	f	NOUN
bjp-20418	84	15	u	u	NOUN
bjp-20418	84	16	5	5	NUM
bjp-20418	84	17	f	f	NOUN
bjp-20418	84	18	u	u	NOUN
bjp-20418	84	19	5	5	NUM
bjp-20418	84	20	f	f	NOUN
bjp-20418	84	21	u	u	NOUN
bjp-20418	84	22	5	5	NUM
bjp-20418	84	23	f	f	NOUN
bjp-20418	84	24	u	u	NOUN
bjp-20418	84	25	c	c	NOUN
bjp-20418	84	26	u	u	NOUN
bjp-20418	84	27	r	r	NOUN
bjp-20418	84	28	c	c	NOUN
bjp-20418	84	29	u	u	NOUN
bjp-20418	84	30	m	m	VERB
bjp-20418	84	31	in	in	ADP
bjp-20418	84	32	&	&	CCONJ
bjp-20418	84	33	5	5	NUM
bjp-20418	84	34	f	f	PROPN
bjp-20418	84	35	u	u	NOUN
bjp-20418	84	36	c	c	NOUN
bjp-20418	84	37	u	u	NOUN
bjp-20418	84	38	r	r	NOUN
bjp-20418	84	39	c	c	NOUN
bjp-20418	84	40	u	u	NOUN
bjp-20418	84	41	m	m	VERB
bjp-20418	84	42	in	in	ADP
bjp-20418	84	43	&	&	CCONJ
bjp-20418	84	44	5	5	NUM
bjp-20418	84	45	f	f	PROPN
bjp-20418	84	46	u	u	NOUN
bjp-20418	85	1	c	c	NOUN
bjp-20418	85	2	u	u	NOUN
bjp-20418	85	3	r	r	NOUN
bjp-20418	85	4	c	c	NOUN
bjp-20418	85	5	u	u	NOUN
bjp-20418	85	6	m	m	VERB
bjp-20418	85	7	in	in	ADP
bjp-20418	85	8	&	&	CCONJ
bjp-20418	85	9	5	5	NUM
bjp-20418	85	10	f	f	PROPN
bjp-20418	85	11	u	u	NOUN
bjp-20418	85	12	c	c	NOUN
bjp-20418	85	13	u	u	NOUN
bjp-20418	85	14	r	r	NOUN
bjp-20418	85	15	c	c	NOUN
bjp-20418	85	16	u	u	NOUN
bjp-20418	85	17	m	m	VERB
bjp-20418	85	18	in	in	ADP
bjp-20418	85	19	&	&	CCONJ
bjp-20418	85	20	5	5	NUM
bjp-20418	85	21	f	f	PROPN
bjp-20418	85	22	u	u	NOUN
bjp-20418	86	1	c	c	NOUN
bjp-20418	86	2	o	o	X
bjp-20418	86	3	n	n	PRON
bjp-20418	86	4	tr	tr	NOUN
bjp-20418	87	1	o	o	NOUN
bjp-20418	87	2	l	l	NOUN
bjp-20418	87	3	c	c	NOUN
bjp-20418	87	4	o	o	X
bjp-20418	87	5	n	n	PRON
bjp-20418	87	6	tr	tr	NOUN
bjp-20418	88	1	o	o	NOUN
bjp-20418	88	2	l	l	NOUN
bjp-20418	88	3	c	c	NOUN
bjp-20418	88	4	o	o	X
bjp-20418	88	5	n	n	PRON
bjp-20418	88	6	tr	tr	NOUN
bjp-20418	89	1	o	o	NOUN
bjp-20418	89	2	l	l	NOUN
bjp-20418	89	3	c	c	NOUN
bjp-20418	89	4	o	o	X
bjp-20418	89	5	n	n	PRON
bjp-20418	89	6	tr	tr	NOUN
bjp-20418	89	7	o	o	NOUN
bjp-20418	89	8	l	l	NOUN
bjp-20418	90	1	*	*	PUNCT
bjp-20418	90	2	*	*	PUNCT
bjp-20418	90	3	relatively	relatively	ADV
bjp-20418	90	4	lower	low	ADJ
bjp-20418	90	5	percentage	percentage	NOUN
bjp-20418	90	6	of	of	ADP
bjp-20418	90	7	cells	cell	NOUN
bjp-20418	90	8	positive	positive	ADJ
bjp-20418	90	9	for	for	ADP
bjp-20418	90	10	apoptosis	apoptosis	NOUN
bjp-20418	90	11	(	(	PUNCT
bjp-20418	90	12	figure	figure	NOUN
bjp-20418	90	13	2	2	NUM
bjp-20418	90	14	)	)	PUNCT
bjp-20418	90	15	.	.	PUNCT
bjp-20418	91	1	furthermore	furthermore	ADV
bjp-20418	91	2	,	,	PUNCT
bjp-20418	91	3	to	to	ADP
bjp-20418	91	4	some	some	DET
bjp-20418	91	5	extent	extent	NOUN
bjp-20418	91	6	they	they	PRON
bjp-20418	91	7	also	also	ADV
bjp-20418	91	8	showed	show	VERB
bjp-20418	91	9	cell	cell	NOUN
bjp-20418	91	10	morphology	morphology	NOUN
bjp-20418	91	11	without	without	ADP
bjp-20418	91	12	nuclear	nuclear	ADJ
bjp-20418	91	13	condensation	condensation	NOUN
bjp-20418	91	14	or	or	CCONJ
bjp-20418	91	15	cell	cell	NOUN
bjp-20418	91	16	shrinkage	shrinkage	NOUN
bjp-20418	91	17	suggesting	suggest	VERB
bjp-20418	91	18	for	for	ADP
bjp-20418	91	19	some	some	PRON
bjp-20418	91	20	necroticlike	necroticlike	ADP
bjp-20418	91	21	cell	cell	NOUN
bjp-20418	91	22	death	death	NOUN
bjp-20418	91	23	.	.	PUNCT
bjp-20418	92	1	in	in	ADP
bjp-20418	92	2	contrast	contrast	NOUN
bjp-20418	92	3	,	,	PUNCT
bjp-20418	92	4	synergistic	synergistic	ADJ
bjp-20418	92	5	treatments	treatment	NOUN
bjp-20418	92	6	in	in	ADP
bjp-20418	92	7	all	all	DET
bjp-20418	92	8	cells	cell	NOUN
bjp-20418	92	9	and	and	CCONJ
bjp-20418	92	10	more	more	ADV
bjp-20418	92	11	prominently	prominently	ADV
bjp-20418	92	12	included	include	VERB
bjp-20418	92	13	the	the	DET
bjp-20418	92	14	apoptotic	apoptotic	ADJ
bjp-20418	92	15	like	like	ADP
bjp-20418	92	16	changes	change	NOUN
bjp-20418	92	17	,	,	PUNCT
bjp-20418	92	18	while	while	SCONJ
bjp-20418	92	19	there	there	PRON
bjp-20418	92	20	is	be	VERB
bjp-20418	92	21	no	no	DET
bjp-20418	92	22	increase	increase	NOUN
bjp-20418	92	23	in	in	ADP
bjp-20418	92	24	necrotic	necrotic	ADJ
bjp-20418	92	25	like	like	ADP
bjp-20418	92	26	changes	change	NOUN
bjp-20418	92	27	.	.	PUNCT
bjp-20418	93	1	this	this	PRON
bjp-20418	93	2	suggests	suggest	VERB
bjp-20418	93	3	that	that	SCONJ
bjp-20418	93	4	with	with	ADP
bjp-20418	93	5	more	more	ADJ
bjp-20418	93	6	drug	drug	NOUN
bjp-20418	93	7	availability	availability	NOUN
bjp-20418	93	8	specific	specific	ADJ
bjp-20418	93	9	preferences	preference	NOUN
bjp-20418	93	10	to	to	ADP
bjp-20418	93	11	certain	certain	ADJ
bjp-20418	93	12	apoptosis	apoptosis	NOUN
bjp-20418	93	13	causing	cause	VERB
bjp-20418	93	14	pathways	pathway	NOUN
bjp-20418	93	15	are	be	AUX
bjp-20418	93	16	prominent	prominent	ADJ
bjp-20418	93	17	and	and	CCONJ
bjp-20418	93	18	hence	hence	ADV
bjp-20418	93	19	there	there	PRON
bjp-20418	93	20	is	be	VERB
bjp-20418	93	21	an	an	DET
bjp-20418	93	22	increase	increase	NOUN
bjp-20418	93	23	only	only	ADV
bjp-20418	93	24	in	in	ADP
bjp-20418	93	25	apoptosis	apoptosis	NOUN
bjp-20418	93	26	.	.	PUNCT
bjp-20418	94	1	in	in	ADP
bjp-20418	94	2	sw620	sw620	PROPN
bjp-20418	94	3	and	and	CCONJ
bjp-20418	94	4	sw480	sw480	ADP
bjp-20418	94	5	cells	cell	NOUN
bjp-20418	94	6	smad	smad	VERB
bjp-20418	94	7	4	4	NUM
bjp-20418	94	8	was	be	AUX
bjp-20418	94	9	undetectable	undetectable	ADJ
bjp-20418	94	10	due	due	ADP
bjp-20418	94	11	to	to	ADP
bjp-20418	94	12	the	the	DET
bjp-20418	94	13	nature	nature	NOUN
bjp-20418	94	14	of	of	ADP
bjp-20418	94	15	the	the	DET
bjp-20418	94	16	mutations	mutation	NOUN
bjp-20418	94	17	.	.	PUNCT
bjp-20418	95	1	in	in	ADP
bjp-20418	95	2	contrast	contrast	NOUN
bjp-20418	95	3	,	,	PUNCT
bjp-20418	95	4	caco2	caco2	NOUN
bjp-20418	95	5	and	and	CCONJ
bjp-20418	95	6	fet-1	fet-1	PUNCT
bjp-20418	95	7	cells	cell	NOUN
bjp-20418	95	8	showed	show	VERB
bjp-20418	95	9	an	an	DET
bjp-20418	95	10	up	up	ADJ
bjp-20418	95	11	-	-	PUNCT
bjp-20418	95	12	regulation	regulation	NOUN
bjp-20418	95	13	of	of	ADP
bjp-20418	95	14	>	>	PRON
bjp-20418	95	15	3	3	NUM
bjp-20418	95	16	-	-	ADJ
bjp-20418	95	17	fold	fold	ADJ
bjp-20418	95	18	induction	induction	NOUN
bjp-20418	95	19	in	in	ADP
bjp-20418	95	20	individual	individual	ADJ
bjp-20418	95	21	treatments	treatment	NOUN
bjp-20418	95	22	and	and	CCONJ
bjp-20418	95	23	further	far	ADV
bjp-20418	95	24	augmented	augment	VERB
bjp-20418	95	25	in	in	ADP
bjp-20418	95	26	combination	combination	NOUN
bjp-20418	95	27	treatments	treatment	NOUN
bjp-20418	95	28	(	(	PUNCT
bjp-20418	95	29	figure	figure	NOUN
bjp-20418	95	30	3	3	NUM
bjp-20418	95	31	)	)	PUNCT
bjp-20418	95	32	.	.	PUNCT
bjp-20418	96	1	however	however	ADV
bjp-20418	96	2	,	,	PUNCT
bjp-20418	96	3	for	for	ADP
bjp-20418	96	4	other	other	ADJ
bjp-20418	96	5	smad	smad	ADJ
bjp-20418	96	6	proteins	protein	NOUN
bjp-20418	96	7	such	such	ADJ
bjp-20418	96	8	as	as	ADP
bjp-20418	96	9	smad	smad	PROPN
bjp-20418	96	10	2/3	2/3	NUM
bjp-20418	96	11	and	and	CCONJ
bjp-20418	96	12	smad7	smad7	NOUN
bjp-20418	96	13	,	,	PUNCT
bjp-20418	96	14	a	a	DET
bjp-20418	96	15	marginal	marginal	ADJ
bjp-20418	96	16	up	up	ADP
bjp-20418	96	17	regulation	regulation	NOUN
bjp-20418	96	18	and	and	CCONJ
bjp-20418	96	19	down	down	ADP
bjp-20418	96	20	-	-	PUNCT
bjp-20418	96	21	regulation	regulation	NOUN
bjp-20418	96	22	was	be	AUX
bjp-20418	96	23	seen	see	VERB
bjp-20418	96	24	only	only	ADV
bjp-20418	96	25	in	in	ADP
bjp-20418	96	26	combination	combination	NOUN
bjp-20418	96	27	treatments	treatment	NOUN
bjp-20418	96	28	respectively	respectively	ADV
bjp-20418	96	29	and	and	CCONJ
bjp-20418	96	30	there	there	PRON
bjp-20418	96	31	was	be	VERB
bjp-20418	96	32	no	no	DET
bjp-20418	96	33	change	change	NOUN
bjp-20418	96	34	in	in	ADP
bjp-20418	96	35	either	either	CCONJ
bjp-20418	96	36	sw620	sw620	PROPN
bjp-20418	96	37	or	or	CCONJ
bjp-20418	96	38	sw480	sw480	PROPN
bjp-20418	96	39	(	(	PUNCT
bjp-20418	96	40	data	datum	NOUN
bjp-20418	96	41	not	not	PART
bjp-20418	96	42	shown	show	VERB
bjp-20418	96	43	)	)	PUNCT
bjp-20418	96	44	.	.	PUNCT
bjp-20418	97	1	these	these	DET
bjp-20418	97	2	data	datum	NOUN
bjp-20418	97	3	together	together	ADV
bjp-20418	97	4	suggest	suggest	VERB
bjp-20418	97	5	as	as	ADP
bjp-20418	97	6	smad4	smad4	NOUN
bjp-20418	97	7	as	as	ADP
bjp-20418	97	8	a	a	DET
bjp-20418	97	9	critical	critical	ADJ
bjp-20418	97	10	modulator	modulator	NOUN
bjp-20418	97	11	associated	associate	VERB
bjp-20418	97	12	with	with	ADP
bjp-20418	97	13	drug	drug	NOUN
bjp-20418	97	14	induced	induce	VERB
bjp-20418	97	15	effects	effect	NOUN
bjp-20418	97	16	in	in	ADP
bjp-20418	97	17	these	these	DET
bjp-20418	97	18	cells	cell	NOUN
bjp-20418	97	19	.	.	PUNCT
bjp-20418	98	1	given	give	VERB
bjp-20418	98	2	that	that	PRON
bjp-20418	98	3	,	,	PUNCT
bjp-20418	98	4	smad4	smad4	NOUN
bjp-20418	98	5	expression	expression	NOUN
bjp-20418	98	6	is	be	AUX
bjp-20418	98	7	modulated	modulate	VERB
bjp-20418	98	8	upon	upon	SCONJ
bjp-20418	98	9	drug	drug	NOUN
bjp-20418	98	10	treatments	treatment	NOUN
bjp-20418	98	11	,	,	PUNCT
bjp-20418	98	12	we	we	PRON
bjp-20418	98	13	reasoned	reason	VERB
bjp-20418	98	14	,	,	PUNCT
bjp-20418	98	15	whether	whether	SCONJ
bjp-20418	98	16	smad4	smad4	NOUN
bjp-20418	98	17	could	could	AUX
bjp-20418	98	18	be	be	AUX
bjp-20418	98	19	mediating	mediate	VERB
bjp-20418	98	20	the	the	DET
bjp-20418	98	21	drug	drug	NOUN
bjp-20418	98	22	-	-	PUNCT
bjp-20418	98	23	induced	induce	VERB
bjp-20418	98	24	apoptosis	apoptosis	NOUN
bjp-20418	98	25	in	in	ADP
bjp-20418	98	26	these	these	DET
bjp-20418	98	27	cells	cell	NOUN
bjp-20418	98	28	.	.	PUNCT
bjp-20418	99	1	to	to	PART
bjp-20418	99	2	evaluate	evaluate	VERB
bjp-20418	99	3	,	,	PUNCT
bjp-20418	99	4	we	we	PRON
bjp-20418	99	5	ectopically	ectopically	ADV
bjp-20418	99	6	overexpressed	overexpresse	VERB
bjp-20418	99	7	smad4	smad4	NOUN
bjp-20418	99	8	in	in	ADP
bjp-20418	99	9	these	these	DET
bjp-20418	99	10	cells	cell	NOUN
bjp-20418	99	11	and	and	CCONJ
bjp-20418	99	12	subjected	subject	VERB
bjp-20418	99	13	to	to	ADP
bjp-20418	99	14	drug	drug	NOUN
bjp-20418	99	15	treatments	treatment	NOUN
bjp-20418	99	16	.	.	PUNCT
bjp-20418	100	1	our	our	PRON
bjp-20418	100	2	results	result	NOUN
bjp-20418	100	3	indicate	indicate	VERB
bjp-20418	100	4	that	that	SCONJ
bjp-20418	100	5	,	,	PUNCT
bjp-20418	100	6	ectopic	ectopic	ADJ
bjp-20418	100	7	expression	expression	NOUN
bjp-20418	100	8	of	of	ADP
bjp-20418	100	9	smad4	smad4	NOUN
bjp-20418	100	10	cells	cell	NOUN
bjp-20418	100	11	increased	increase	VERB
bjp-20418	100	12	the	the	DET
bjp-20418	100	13	response	response	NOUN
bjp-20418	100	14	of	of	ADP
bjp-20418	100	15	cancer	cancer	NOUN
bjp-20418	100	16	cells	cell	NOUN
bjp-20418	100	17	and	and	CCONJ
bjp-20418	100	18	increased	increase	VERB
bjp-20418	100	19	the	the	DET
bjp-20418	100	20	apoptosis	apoptosis	NOUN
bjp-20418	100	21	in	in	ADP
bjp-20418	100	22	fet	fet	PROPN
bjp-20418	100	23	and	and	CCONJ
bjp-20418	100	24	caco2	caco2	NOUN
bjp-20418	100	25	cells	cell	NOUN
bjp-20418	100	26	(	(	PUNCT
bjp-20418	100	27	figure	figure	NOUN
bjp-20418	100	28	4	4	NUM
bjp-20418	100	29	)	)	PUNCT
bjp-20418	100	30	.	.	PUNCT
bjp-20418	101	1	more	more	ADV
bjp-20418	101	2	importantly	importantly	ADV
bjp-20418	101	3	,	,	PUNCT
bjp-20418	101	4	drug	drug	NOUN
bjp-20418	101	5	treatments	treatment	NOUN
bjp-20418	101	6	induced	induce	VERB
bjp-20418	101	7	increased	increase	VERB
bjp-20418	101	8	apoptosis	apoptosis	NOUN
bjp-20418	101	9	in	in	ADP
bjp-20418	101	10	sw620	sw620	ADJ
bjp-20418	101	11	and	and	CCONJ
bjp-20418	101	12	sw480	sw480	PROPN
bjp-20418	101	13	cells	cell	NOUN
bjp-20418	101	14	as	as	ADV
bjp-20418	101	15	well	well	ADV
bjp-20418	101	16	upon	upon	SCONJ
bjp-20418	101	17	overexpressing	overexpresse	VERB
bjp-20418	101	18	smad4	smad4	NOUN
bjp-20418	101	19	in	in	ADP
bjp-20418	101	20	them	they	PRON
bjp-20418	101	21	.	.	PUNCT
bjp-20418	102	1	taken	take	VERB
bjp-20418	102	2	together	together	ADV
bjp-20418	102	3	,	,	PUNCT
bjp-20418	102	4	these	these	DET
bjp-20418	102	5	results	result	NOUN
bjp-20418	102	6	suggest	suggest	VERB
bjp-20418	102	7	a	a	DET
bjp-20418	102	8	direct	direct	ADJ
bjp-20418	102	9	role	role	NOUN
bjp-20418	102	10	for	for	ADP
bjp-20418	102	11	smad4	smad4	NOUN
bjp-20418	102	12	in	in	ADP
bjp-20418	102	13	druginduced	druginduced	ADJ
bjp-20418	102	14	apoptosis	apoptosis	NOUN
bjp-20418	102	15	.	.	PUNCT
bjp-20418	103	1	give	give	VERB
bjp-20418	103	2	with	with	ADP
bjp-20418	103	3	our	our	PRON
bjp-20418	103	4	observation	observation	NOUN
bjp-20418	103	5	in	in	ADP
bjp-20418	103	6	these	these	DET
bjp-20418	103	7	cells	cell	NOUN
bjp-20418	103	8	,	,	PUNCT
bjp-20418	103	9	we	we	PRON
bjp-20418	103	10	also	also	ADV
bjp-20418	103	11	evaluated	evaluate	VERB
bjp-20418	103	12	if	if	SCONJ
bjp-20418	103	13	there	there	PRON
bjp-20418	103	14	is	be	VERB
bjp-20418	103	15	any	any	DET
bjp-20418	103	16	correlation	correlation	NOUN
bjp-20418	103	17	between	between	ADP
bjp-20418	103	18	smad	smad	PROPN
bjp-20418	103	19	mutations	mutation	NOUN
bjp-20418	103	20	and	and	CCONJ
bjp-20418	103	21	chemotherapy	chemotherapy	NOUN
bjp-20418	103	22	outcomes	outcome	NOUN
bjp-20418	103	23	.	.	PUNCT
bjp-20418	104	1	we	we	PRON
bjp-20418	104	2	did	do	AUX
bjp-20418	104	3	correlative	correlative	ADJ
bjp-20418	104	4	analysis	analysis	NOUN
bjp-20418	104	5	with	with	ADP
bjp-20418	104	6	157	157	NUM
bjp-20418	104	7	patients	patient	NOUN
bjp-20418	104	8	(	(	PUNCT
bjp-20418	104	9	130	130	NUM
bjp-20418	104	10	-	-	PUNCT
bjp-20418	104	11	mutations	mutation	NOUN
bjp-20418	104	12	previously	previously	ADV
bjp-20418	104	13	identified	identify	VERB
bjp-20418	104	14	)	)	PUNCT
bjp-20418	104	15	subjected	subject	VERB
bjp-20418	104	16	to	to	ADP
bjp-20418	104	17	chemotherapy	chemotherapy	NOUN
bjp-20418	104	18	and	and	CCONJ
bjp-20418	104	19	their	their	PRON
bjp-20418	104	20	outcomes	outcome	NOUN
bjp-20418	104	21	known	know	VERB
bjp-20418	104	22	.	.	PUNCT
bjp-20418	105	1	our	our	PRON
bjp-20418	105	2	data	datum	NOUN
bjp-20418	105	3	showed	show	VERB
bjp-20418	105	4	a	a	DET
bjp-20418	105	5	strong	strong	ADJ
bjp-20418	105	6	association	association	NOUN
bjp-20418	105	7	(	(	PUNCT
bjp-20418	105	8	>	>	SYM
bjp-20418	105	9	95	95	NUM
bjp-20418	105	10	%	%	NOUN
bjp-20418	105	11	)	)	PUNCT
bjp-20418	105	12	between	between	ADP
bjp-20418	105	13	aberrant	aberrant	ADJ
bjp-20418	105	14	smad	smad	NOUN
bjp-20418	105	15	gene	gene	NOUN
bjp-20418	105	16	mutations	mutation	NOUN
bjp-20418	105	17	(	(	PUNCT
bjp-20418	105	18	all	all	DET
bjp-20418	105	19	smad	smad	ADJ
bjp-20418	105	20	genes	gene	NOUN
bjp-20418	105	21	)	)	PUNCT
bjp-20418	105	22	and	and	CCONJ
bjp-20418	105	23	tumor	tumor	NOUN
bjp-20418	105	24	relapse	relapse	NOUN
bjp-20418	105	25	after	after	ADP
bjp-20418	105	26	chemotherapy	chemotherapy	NOUN
bjp-20418	105	27	(	(	PUNCT
bjp-20418	105	28	figure	figure	NOUN
bjp-20418	105	29	5	5	NUM
bjp-20418	105	30	)	)	PUNCT
bjp-20418	105	31	,	,	PUNCT
bjp-20418	105	32	suggesting	suggest	VERB
bjp-20418	105	33	that	that	SCONJ
bjp-20418	105	34	smad	smad	PROPN
bjp-20418	105	35	signaling	signal	VERB
bjp-20418	105	36	is	be	AUX
bjp-20418	105	37	critical	critical	ADJ
bjp-20418	105	38	to	to	PART
bjp-20418	105	39	mediate	mediate	VERB
bjp-20418	105	40	effective	effective	ADJ
bjp-20418	105	41	chemotherapy	chemotherapy	NOUN
bjp-20418	105	42	.	.	PUNCT
bjp-20418	106	1	although	although	SCONJ
bjp-20418	106	2	,	,	PUNCT
bjp-20418	106	3	our	our	PRON
bjp-20418	106	4	cell	cell	NOUN
bjp-20418	106	5	line	line	NOUN
bjp-20418	106	6	data	datum	NOUN
bjp-20418	106	7	indicate	indicate	VERB
bjp-20418	106	8	that	that	SCONJ
bjp-20418	106	9	only	only	ADV
bjp-20418	106	10	smad4	smad4	NOUN
bjp-20418	106	11	is	be	AUX
bjp-20418	106	12	largely	largely	ADV
bjp-20418	106	13	changed	change	VERB
bjp-20418	106	14	with	with	ADP
bjp-20418	106	15	tested	test	VERB
bjp-20418	106	16	drug	drug	NOUN
bjp-20418	106	17	treatments	treatment	NOUN
bjp-20418	106	18	(	(	PUNCT
bjp-20418	106	19	fet-1	fet-1	NUM
bjp-20418	106	20	and	and	CCONJ
bjp-20418	106	21	caco2	caco2	NOUN
bjp-20418	106	22	cells	cell	NOUN
bjp-20418	106	23	)	)	PUNCT
bjp-20418	106	24	,	,	PUNCT
bjp-20418	106	25	our	our	PRON
bjp-20418	106	26	patient	patient	NOUN
bjp-20418	106	27	-	-	PUNCT
bjp-20418	106	28	treatment	treatment	NOUN
bjp-20418	106	29	information	information	NOUN
bjp-20418	106	30	analysis	analysis	NOUN
bjp-20418	106	31	showed	show	VERB
bjp-20418	106	32	that	that	SCONJ
bjp-20418	106	33	mutations	mutation	NOUN
bjp-20418	106	34	in	in	ADP
bjp-20418	106	35	other	other	ADJ
bjp-20418	106	36	smad	smad	ADJ
bjp-20418	106	37	genes	gene	NOUN
bjp-20418	106	38	were	be	AUX
bjp-20418	106	39	also	also	ADV
bjp-20418	106	40	associated	associate	VERB
bjp-20418	106	41	with	with	ADP
bjp-20418	106	42	the	the	DET
bjp-20418	106	43	tumor	tumor	NOUN
bjp-20418	106	44	relapse	relapse	NOUN
bjp-20418	106	45	phenotype	phenotype	NOUN
bjp-20418	106	46	.	.	PUNCT
bjp-20418	107	1	we	we	PRON
bjp-20418	107	2	speculate	speculate	VERB
bjp-20418	107	3	that	that	SCONJ
bjp-20418	107	4	other	other	ADJ
bjp-20418	107	5	smad	smad	PROPN
bjp-20418	107	6	gene	gene	NOUN
bjp-20418	107	7	mutations	mutation	NOUN
bjp-20418	107	8	could	could	AUX
bjp-20418	107	9	impact	impact	VERB
bjp-20418	107	10	on	on	ADP
bjp-20418	107	11	smad4	smad4	NOUN
bjp-20418	107	12	functions	function	NOUN
bjp-20418	107	13	and	and	CCONJ
bjp-20418	107	14	cause	cause	VERB
bjp-20418	107	15	impaired	impaired	ADJ
bjp-20418	107	16	response	response	NOUN
bjp-20418	107	17	in	in	ADP
bjp-20418	107	18	chemotherapy	chemotherapy	NOUN
bjp-20418	107	19	.	.	PUNCT
bjp-20418	108	1	discussion	discussion	NOUN
bjp-20418	108	2	colon	colon	NOUN
bjp-20418	108	3	cancer	cancer	NOUN
bjp-20418	108	4	continues	continue	VERB
bjp-20418	108	5	to	to	PART
bjp-20418	108	6	remain	remain	VERB
bjp-20418	108	7	as	as	ADP
bjp-20418	108	8	one	one	NUM
bjp-20418	108	9	of	of	ADP
bjp-20418	108	10	the	the	DET
bjp-20418	108	11	major	major	ADJ
bjp-20418	108	12	malignancy	malignancy	NOUN
bjp-20418	108	13	in	in	ADP
bjp-20418	108	14	most	most	ADJ
bjp-20418	108	15	countries	country	NOUN
bjp-20418	108	16	(	(	PUNCT
bjp-20418	108	17	labianca	labianca	NOUN
bjp-20418	108	18	et	et	PROPN
bjp-20418	108	19	al	al	PROPN
bjp-20418	108	20	.	.	PROPN
bjp-20418	108	21	,	,	PUNCT
bjp-20418	108	22	2010	2010	NUM
bjp-20418	108	23	)	)	PUNCT
bjp-20418	108	24	.	.	PUNCT
bjp-20418	109	1	abnormalities	abnormality	NOUN
bjp-20418	109	2	in	in	ADP
bjp-20418	109	3	smad	smad	PROPN
bjp-20418	109	4	signaling	signal	VERB
bjp-20418	109	5	have	have	VERB
bjp-20418	109	6	a	a	DET
bjp-20418	109	7	major	major	ADJ
bjp-20418	109	8	role	role	NOUN
bjp-20418	109	9	in	in	ADP
bjp-20418	109	10	the	the	DET
bjp-20418	109	11	development	development	NOUN
bjp-20418	109	12	of	of	ADP
bjp-20418	109	13	colon	colon	NOUN
bjp-20418	109	14	cancer	cancer	NOUN
bjp-20418	109	15	(	(	PUNCT
bjp-20418	109	16	massague	massague	NOUN
bjp-20418	109	17	et	et	PROPN
bjp-20418	109	18	al	al	PROPN
bjp-20418	109	19	.	.	PROPN
bjp-20418	109	20	,	,	PUNCT
bjp-20418	109	21	2008	2008	NUM
bjp-20418	109	22	;	;	PUNCT
bjp-20418	109	23	fleming	fleme	VERB
bjp-20418	109	24	et	et	PROPN
bjp-20418	109	25	al	al	PROPN
bjp-20418	109	26	.	.	PROPN
bjp-20418	109	27	,	,	PUNCT
bjp-20418	109	28	2013	2013	NUM
bjp-20418	109	29	)	)	PUNCT
bjp-20418	109	30	.	.	PUNCT
bjp-20418	110	1	in	in	ADP
bjp-20418	110	2	the	the	DET
bjp-20418	110	3	present	present	ADJ
bjp-20418	110	4	study	study	NOUN
bjp-20418	110	5	the	the	DET
bjp-20418	110	6	efficiency	efficiency	NOUN
bjp-20418	110	7	of	of	ADP
bjp-20418	110	8	drugs	drug	NOUN
bjp-20418	110	9	in	in	ADP
bjp-20418	110	10	inducing	induce	VERB
bjp-20418	110	11	apoptosis	apoptosis	NOUN
bjp-20418	110	12	was	be	AUX
bjp-20418	110	13	analyzed	analyze	VERB
bjp-20418	110	14	in	in	ADP
bjp-20418	110	15	four	four	NUM
bjp-20418	110	16	colon	colon	NOUN
bjp-20418	110	17	cancer	cancer	NOUN
bjp-20418	110	18	cell	cell	NOUN
bjp-20418	110	19	lines	line	NOUN
bjp-20418	110	20	,	,	PUNCT
bjp-20418	110	21	fet	fet	NOUN
bjp-20418	110	22	,	,	PUNCT
bjp-20418	110	23	caco2	caco2	NOUN
bjp-20418	110	24	,	,	PUNCT
bjp-20418	110	25	and	and	CCONJ
bjp-20418	110	26	two	two	NUM
bjp-20418	110	27	related	relate	VERB
bjp-20418	110	28	smad	smad	NOUN
bjp-20418	110	29	nonresponsive	nonresponsive	ADJ
bjp-20418	110	30	cells	cell	NOUN
bjp-20418	110	31	,	,	PUNCT
bjp-20418	110	32	sw620	sw620	ADJ
bjp-20418	110	33	and	and	CCONJ
bjp-20418	110	34	sw480	sw480	PROPN
bjp-20418	110	35	.	.	PUNCT
bjp-20418	111	1	the	the	DET
bjp-20418	111	2	drugs	drug	NOUN
bjp-20418	111	3	(	(	PUNCT
bjp-20418	111	4	5	5	NUM
bjp-20418	111	5	-	-	PUNCT
bjp-20418	111	6	fluorouracil	fluorouracil	NOUN
bjp-20418	111	7	and	and	CCONJ
bjp-20418	111	8	curcumin	curcumin	NOUN
bjp-20418	111	9	)	)	PUNCT
bjp-20418	111	10	were	be	AUX
bjp-20418	111	11	selected	select	VERB
bjp-20418	111	12	based	base	VERB
bjp-20418	111	13	on	on	ADP
bjp-20418	111	14	their	their	PRON
bjp-20418	111	15	utility	utility	NOUN
bjp-20418	111	16	in	in	ADP
bjp-20418	111	17	crc	crc	NOUN
bjp-20418	111	18	chemotherapy	chemotherapy	NOUN
bjp-20418	111	19	or	or	CCONJ
bjp-20418	111	20	their	their	PRON
bjp-20418	111	21	ability	ability	NOUN
bjp-20418	111	22	to	to	PART
bjp-20418	111	23	induce	induce	VERB
bjp-20418	111	24	apoptosis	apoptosis	NOUN
bjp-20418	111	25	in	in	ADP
bjp-20418	111	26	a	a	DET
bjp-20418	111	27	wide	wide	ADJ
bjp-20418	111	28	range	range	NOUN
bjp-20418	111	29	of	of	ADP
bjp-20418	111	30	cancer	cancer	NOUN
bjp-20418	111	31	cells	cell	NOUN
bjp-20418	111	32	.	.	PUNCT
bjp-20418	112	1	the	the	DET
bjp-20418	112	2	mtt	mtt	NOUN
bjp-20418	112	3	assay	assay	VERB
bjp-20418	112	4	results	result	NOUN
bjp-20418	112	5	show	show	VERB
bjp-20418	112	6	that	that	SCONJ
bjp-20418	112	7	both	both	DET
bjp-20418	112	8	drugs	drug	NOUN
bjp-20418	112	9	were	be	AUX
bjp-20418	112	10	able	able	ADJ
bjp-20418	112	11	to	to	PART
bjp-20418	112	12	decrease	decrease	VERB
bjp-20418	112	13	the	the	DET
bjp-20418	112	14	viability	viability	NOUN
bjp-20418	112	15	and	and	CCONJ
bjp-20418	112	16	the	the	DET
bjp-20418	112	17	effects	effect	NOUN
bjp-20418	112	18	were	be	AUX
bjp-20418	112	19	more	more	ADJ
bjp-20418	112	20	in	in	ADP
bjp-20418	112	21	the	the	DET
bjp-20418	112	22	combination	combination	NOUN
bjp-20418	112	23	treatments	treatment	NOUN
bjp-20418	112	24	.	.	PUNCT
bjp-20418	113	1	earlier	early	ADJ
bjp-20418	113	2	reports	report	NOUN
bjp-20418	113	3	have	have	AUX
bjp-20418	113	4	shown	show	VERB
bjp-20418	113	5	that	that	SCONJ
bjp-20418	113	6	curcumin	curcumin	NOUN
bjp-20418	113	7	can	can	AUX
bjp-20418	113	8	induce	induce	VERB
bjp-20418	113	9	apoptosis	apoptosis	NOUN
bjp-20418	113	10	in	in	ADP
bjp-20418	113	11	many	many	ADJ
bjp-20418	113	12	cancer	cancer	NOUN
bjp-20418	113	13	cell	cell	NOUN
bjp-20418	113	14	lines	line	NOUN
bjp-20418	113	15	(	(	PUNCT
bjp-20418	113	16	hossain	hossain	PROPN
bjp-20418	113	17	et	et	PROPN
bjp-20418	113	18	al	al	PROPN
bjp-20418	113	19	.	.	PROPN
bjp-20418	113	20	,	,	PUNCT
bjp-20418	113	21	2012	2012	NUM
bjp-20418	113	22	)	)	PUNCT
bjp-20418	113	23	.	.	PUNCT
bjp-20418	114	1	however	however	ADV
bjp-20418	114	2	,	,	PUNCT
bjp-20418	114	3	in	in	ADP
bjp-20418	114	4	colon	colon	NOUN
bjp-20418	114	5	cancer	cancer	NOUN
bjp-20418	114	6	cells	cell	NOUN
bjp-20418	114	7	it	it	PRON
bjp-20418	114	8	remains	remain	VERB
bjp-20418	114	9	largely	largely	ADV
bjp-20418	114	10	unknown	unknown	ADJ
bjp-20418	114	11	.	.	PUNCT
bjp-20418	115	1	on	on	ADP
bjp-20418	115	2	the	the	DET
bjp-20418	115	3	other	other	ADJ
bjp-20418	115	4	hand	hand	NOUN
bjp-20418	115	5	,	,	PUNCT
bjp-20418	115	6	5	5	NUM
bjp-20418	115	7	-	-	PUNCT
bjp-20418	115	8	fluorouracil	fluorouracil	NOUN
bjp-20418	115	9	has	have	AUX
bjp-20418	115	10	been	be	AUX
bjp-20418	115	11	widely	widely	ADV
bjp-20418	115	12	used	use	VERB
bjp-20418	115	13	for	for	ADP
bjp-20418	115	14	colon	colon	NOUN
bjp-20418	115	15	cancer	cancer	NOUN
bjp-20418	115	16	chemotherapy	chemotherapy	NOUN
bjp-20418	115	17	,	,	PUNCT
bjp-20418	115	18	and	and	CCONJ
bjp-20418	115	19	discrepancies	discrepancy	NOUN
bjp-20418	115	20	in	in	ADP
bjp-20418	115	21	outcomes	outcome	NOUN
bjp-20418	115	22	are	be	AUX
bjp-20418	115	23	observed	observe	VERB
bjp-20418	115	24	(	(	PUNCT
bjp-20418	115	25	pasetto	pasetto	NOUN
bjp-20418	115	26	et	et	PROPN
bjp-20418	115	27	al	al	PROPN
bjp-20418	115	28	.	.	PROPN
bjp-20418	115	29	,	,	PUNCT
bjp-20418	115	30	2006	2006	NUM
bjp-20418	115	31	)	)	PUNCT
bjp-20418	115	32	.	.	PUNCT
bjp-20418	116	1	these	these	DET
bjp-20418	116	2	data	datum	NOUN
bjp-20418	116	3	indicate	indicate	VERB
bjp-20418	116	4	that	that	SCONJ
bjp-20418	116	5	both	both	CCONJ
bjp-20418	116	6	the	the	DET
bjp-20418	116	7	drugs	drug	NOUN
bjp-20418	116	8	mediated	mediate	VERB
bjp-20418	116	9	prominently	prominently	ADV
bjp-20418	116	10	only	only	ADV
bjp-20418	116	11	in	in	ADP
bjp-20418	116	12	a	a	DET
bjp-20418	116	13	subset	subset	NOUN
bjp-20418	116	14	of	of	ADP
bjp-20418	116	15	cancer	cancer	NOUN
bjp-20418	116	16	cells	cell	NOUN
bjp-20418	116	17	tested	test	VERB
bjp-20418	116	18	.	.	PUNCT
bjp-20418	117	1	sw620	sw620	ADJ
bjp-20418	117	2	and	and	CCONJ
bjp-20418	117	3	sw480	sw480	ADV
bjp-20418	117	4	being	be	AUX
bjp-20418	117	5	smad	smad	ADJ
bjp-20418	117	6	non	non	ADJ
bjp-20418	117	7	-	-	ADJ
bjp-20418	117	8	responsive	responsive	ADJ
bjp-20418	117	9	mutant	mutant	ADJ
bjp-20418	117	10	lines	line	NOUN
bjp-20418	117	11	showed	show	VERB
bjp-20418	117	12	less	less	ADJ
bjp-20418	117	13	apoptosis	apoptosis	NOUN
bjp-20418	117	14	induction	induction	NOUN
bjp-20418	117	15	,	,	PUNCT
bjp-20418	117	16	suggesting	suggest	VERB
bjp-20418	117	17	that	that	SCONJ
bjp-20418	117	18	smad	smad	PROPN
bjp-20418	117	19	proteins	protein	NOUN
bjp-20418	117	20	may	may	AUX
bjp-20418	117	21	mediate	mediate	VERB
bjp-20418	117	22	drug	drug	NOUN
bjp-20418	117	23	-	-	PUNCT
bjp-20418	117	24	induced	induce	VERB
bjp-20418	117	25	apoptosis	apoptosis	NOUN
bjp-20418	117	26	.	.	PUNCT
bjp-20418	118	1	in	in	ADP
bjp-20418	118	2	accordance	accordance	NOUN
bjp-20418	118	3	with	with	ADP
bjp-20418	118	4	the	the	DET
bjp-20418	118	5	induction	induction	NOUN
bjp-20418	118	6	of	of	ADP
bjp-20418	118	7	increased	increase	VERB
bjp-20418	118	8	apoptosis	apoptosis	NOUN
bjp-20418	118	9	by	by	ADP
bjp-20418	118	10	these	these	DET
bjp-20418	118	11	drugs	drug	NOUN
bjp-20418	118	12	the	the	DET
bjp-20418	118	13	expression	expression	NOUN
bjp-20418	118	14	levels	level	NOUN
bjp-20418	118	15	of	of	ADP
bjp-20418	118	16	smad	smad	ADJ
bjp-20418	118	17	proteins	protein	NOUN
bjp-20418	118	18	is	be	AUX
bjp-20418	118	19	also	also	ADV
bjp-20418	118	20	positively	positively	ADV
bjp-20418	118	21	modulated	modulate	VERB
bjp-20418	118	22	in	in	ADP
bjp-20418	118	23	smad	smad	PROPN
bjp-20418	118	24	responsive	responsive	ADJ
bjp-20418	118	25	cells	cell	NOUN
bjp-20418	118	26	.	.	PUNCT
bjp-20418	119	1	the	the	DET
bjp-20418	119	2	smad	smad	PROPN
bjp-20418	119	3	dependence	dependence	NOUN
bjp-20418	119	4	is	be	AUX
bjp-20418	119	5	further	far	ADV
bjp-20418	119	6	confirmed	confirm	VERB
bjp-20418	119	7	as	as	SCONJ
bjp-20418	119	8	the	the	DET
bjp-20418	119	9	phenotype	phenotype	NOUN
bjp-20418	119	10	is	be	AUX
bjp-20418	119	11	reversed	reverse	VERB
bjp-20418	119	12	and	and	CCONJ
bjp-20418	119	13	increased	increase	VERB
bjp-20418	119	14	cell	cell	NOUN
bjp-20418	119	15	death	death	NOUN
bjp-20418	119	16	is	be	AUX
bjp-20418	119	17	seen	see	VERB
bjp-20418	119	18	upon	upon	SCONJ
bjp-20418	119	19	over	over	ADP
bjp-20418	119	20	expression	expression	NOUN
bjp-20418	119	21	of	of	ADP
bjp-20418	119	22	smad4	smad4	NOUN
bjp-20418	119	23	in	in	ADP
bjp-20418	119	24	sw620	sw620	PROPN
bjp-20418	119	25	and	and	CCONJ
bjp-20418	119	26	sw480	sw480	PROPN
bjp-20418	119	27	.	.	PUNCT
bjp-20418	120	1	bangladesh	bangladesh	PROPN
bjp-20418	120	2	j	j	PROPN
bjp-20418	120	3	pharmacol	pharmacol	PROPN
bjp-20418	120	4	2014	2014	NUM
bjp-20418	120	5	;	;	PUNCT
bjp-20418	120	6	9	9	NUM
bjp-20418	120	7	:	:	SYM
bjp-20418	120	8	539	539	NUM
bjp-20418	120	9	-	-	SYM
bjp-20418	120	10	544	544	NUM
bjp-20418	120	11	543	543	NUM
bjp-20418	120	12	s	s	VERB
bjp-20418	120	13	m	m	NOUN
bjp-20418	120	14	a	a	DET
bjp-20418	120	15	d	d	NOUN
bjp-20418	120	16	n	n	ADP
bjp-20418	120	17	o	o	NOUN
bjp-20418	120	18	n	n	CCONJ
bjp-20418	120	19	-s	-s	PROPN
bjp-20418	120	20	m	m	VERB
bjp-20418	120	21	a	a	PRON
bjp-20418	120	22	d	d	X
bjp-20418	120	23	u	u	NOUN
bjp-20418	120	24	n	n	PROPN
bjp-20418	120	25	i	i	PROPN
bjp-20418	120	26	d	d	PROPN
bjp-20418	120	27	e	e	PROPN
bjp-20418	120	28	n	n	X
bjp-20418	120	29	ti	ti	NOUN
bjp-20418	120	30	fi	fi	NOUN
bjp-20418	120	31	e	e	X
bjp-20418	120	32	d	d	X
bjp-20418	120	33	0	0	NUM
bjp-20418	120	34	5	5	NUM
bjp-20418	120	35	0	0	NUM
bjp-20418	120	36	1	1	NUM
bjp-20418	120	37	0	0	NUM
bjp-20418	120	38	0	0	NUM
bjp-20418	120	39	1	1	NUM
bjp-20418	120	40	5	5	NUM
bjp-20418	120	41	0	0	NUM
bjp-20418	120	42	r	r	NOUN
bjp-20418	120	43	e	e	NOUN
bjp-20418	120	44	la	la	NOUN
bjp-20418	120	45	p	p	X
bjp-20418	120	46	s	s	X
bjp-20418	120	47	e	e	X
bjp-20418	120	48	d	d	NOUN
bjp-20418	120	49	r	r	NOUN
bjp-20418	120	50	e	e	NOUN
bjp-20418	120	51	c	c	NOUN
bjp-20418	120	52	o	o	X
bjp-20418	120	53	v	v	X
bjp-20418	120	54	e	e	X
bjp-20418	120	55	re	re	NOUN
bjp-20418	120	56	d	d	PROPN
bjp-20418	120	57	n	n	PRON
bjp-20418	120	58	o	o	NOUN
bjp-20418	120	59	.o	.o	PROPN
bjp-20418	121	1	f	f	X
bjp-20418	121	2	c	c	PROPN
bjp-20418	121	3	a	a	DET
bjp-20418	121	4	s	s	X
bjp-20418	121	5	e	e	NOUN
bjp-20418	121	6	s	s	NOUN
bjp-20418	121	7	figure	figure	NOUN
bjp-20418	121	8	5	5	NUM
bjp-20418	121	9	:	:	PUNCT
bjp-20418	121	10	association	association	NOUN
bjp-20418	121	11	of	of	ADP
bjp-20418	121	12	chemotherapy	chemotherapy	NOUN
bjp-20418	121	13	response	response	NOUN
bjp-20418	121	14	with	with	ADP
bjp-20418	121	15	causative	causative	ADJ
bjp-20418	121	16	mutations	mutation	NOUN
bjp-20418	121	17	patients	patient	NOUN
bjp-20418	121	18	(	(	PUNCT
bjp-20418	121	19	n	n	NOUN
bjp-20418	121	20	=	=	SYM
bjp-20418	121	21	157	157	NUM
bjp-20418	121	22	)	)	PUNCT
bjp-20418	121	23	were	be	AUX
bjp-20418	121	24	grouped	group	VERB
bjp-20418	121	25	into	into	ADP
bjp-20418	121	26	three	three	NUM
bjp-20418	121	27	groups	group	NOUN
bjp-20418	121	28	based	base	VERB
bjp-20418	121	29	on	on	ADP
bjp-20418	121	30	the	the	DET
bjp-20418	121	31	mutations	mutation	NOUN
bjp-20418	121	32	(	(	PUNCT
bjp-20418	121	33	smad	smad	PROPN
bjp-20418	121	34	family	family	NOUN
bjp-20418	121	35	(	(	PUNCT
bjp-20418	121	36	n	n	NOUN
bjp-20418	121	37	=	=	SYM
bjp-20418	121	38	26	26	NUM
bjp-20418	121	39	)	)	PUNCT
bjp-20418	121	40	,	,	PUNCT
bjp-20418	121	41	non	non	ADJ
bjp-20418	121	42	-	-	ADJ
bjp-20418	121	43	smad	smad	ADJ
bjp-20418	121	44	(	(	PUNCT
bjp-20418	121	45	n	n	NOUN
bjp-20418	121	46	=	=	SYM
bjp-20418	121	47	104	104	NUM
bjp-20418	121	48	)	)	PUNCT
bjp-20418	121	49	and	and	CCONJ
bjp-20418	121	50	unidentified	unidentified	ADJ
bjp-20418	121	51	(	(	PUNCT
bjp-20418	121	52	n	n	NOUN
bjp-20418	121	53	=	=	NUM
bjp-20418	121	54	27	27	NUM
bjp-20418	121	55	)	)	PUNCT
bjp-20418	121	56	.	.	PUNCT
bjp-20418	122	1	the	the	DET
bjp-20418	122	2	response	response	NOUN
bjp-20418	122	3	seen	see	VERB
bjp-20418	122	4	in	in	ADP
bjp-20418	122	5	these	these	DET
bjp-20418	122	6	patients	patient	NOUN
bjp-20418	122	7	after	after	SCONJ
bjp-20418	122	8	chemotherapy	chemotherapy	NOUN
bjp-20418	122	9	were	be	AUX
bjp-20418	122	10	graphed	graph	VERB
bjp-20418	122	11	,	,	PUNCT
bjp-20418	122	12	which	which	PRON
bjp-20418	122	13	exhibit	exhibit	VERB
bjp-20418	122	14	a	a	DET
bjp-20418	122	15	strong	strong	ADJ
bjp-20418	122	16	associa	associa	NOUN
bjp-20418	122	17	-	-	PUNCT
bjp-20418	122	18	tion	tion	NOUN
bjp-20418	122	19	between	between	ADP
bjp-20418	122	20	smad	smad	PROPN
bjp-20418	122	21	mutations	mutation	NOUN
bjp-20418	122	22	and	and	CCONJ
bjp-20418	122	23	tumor	tumor	NOUN
bjp-20418	122	24	relapse	relapse	NOUN
bjp-20418	122	25	smad	smad	PROPN
bjp-20418	122	26	proteins	protein	NOUN
bjp-20418	122	27	are	be	AUX
bjp-20418	122	28	known	know	VERB
bjp-20418	122	29	to	to	PART
bjp-20418	122	30	modulate	modulate	VERB
bjp-20418	122	31	to	to	ADP
bjp-20418	122	32	wide	wide	ADJ
bjp-20418	122	33	range	range	NOUN
bjp-20418	122	34	of	of	ADP
bjp-20418	122	35	processes	process	NOUN
bjp-20418	122	36	and	and	CCONJ
bjp-20418	122	37	are	be	AUX
bjp-20418	122	38	associated	associate	VERB
bjp-20418	122	39	with	with	ADP
bjp-20418	122	40	many	many	ADJ
bjp-20418	122	41	signaling	signal	VERB
bjp-20418	122	42	pathways	pathway	NOUN
bjp-20418	122	43	such	such	ADJ
bjp-20418	122	44	as	as	ADP
bjp-20418	122	45	nf	nf	NOUN
bjp-20418	122	46	-	-	PUNCT
bjp-20418	122	47	kappa	kappa	NOUN
bjp-20418	122	48	b	b	PROPN
bjp-20418	122	49	,	,	PUNCT
bjp-20418	122	50	pi3k	pi3k	PROPN
bjp-20418	122	51	/	/	SYM
bjp-20418	122	52	akt	akt	PROPN
bjp-20418	122	53	pathways	pathway	NOUN
bjp-20418	122	54	(	(	PUNCT
bjp-20418	122	55	grau	grau	PROPN
bjp-20418	122	56	et	et	PROPN
bjp-20418	122	57	al	al	PROPN
bjp-20418	122	58	.	.	PROPN
bjp-20418	122	59	,	,	PUNCT
bjp-20418	122	60	2006	2006	NUM
bjp-20418	122	61	;	;	PUNCT
bjp-20418	122	62	zhang	zhang	PROPN
bjp-20418	122	63	et	et	PROPN
bjp-20418	122	64	al	al	PROPN
bjp-20418	122	65	.	.	PROPN
bjp-20418	122	66	,	,	PUNCT
bjp-20418	122	67	2013	2013	NUM
bjp-20418	122	68	)	)	PUNCT
bjp-20418	122	69	.	.	PUNCT
bjp-20418	123	1	dissecting	dissect	VERB
bjp-20418	123	2	the	the	DET
bjp-20418	123	3	pathways	pathway	NOUN
bjp-20418	123	4	with	with	ADP
bjp-20418	123	5	the	the	DET
bjp-20418	123	6	context	context	NOUN
bjp-20418	123	7	of	of	ADP
bjp-20418	123	8	drug	drug	NOUN
bjp-20418	123	9	induced	induce	VERB
bjp-20418	123	10	responses	response	NOUN
bjp-20418	123	11	would	would	AUX
bjp-20418	123	12	be	be	AUX
bjp-20418	123	13	of	of	ADP
bjp-20418	123	14	more	more	ADJ
bjp-20418	123	15	importance	importance	NOUN
bjp-20418	123	16	to	to	PART
bjp-20418	123	17	understand	understand	VERB
bjp-20418	123	18	the	the	DET
bjp-20418	123	19	role	role	NOUN
bjp-20418	123	20	smad	smad	VERB
bjp-20418	123	21	in	in	ADP
bjp-20418	123	22	mediating	mediate	VERB
bjp-20418	123	23	the	the	DET
bjp-20418	123	24	apoptosis	apoptosis	NOUN
bjp-20418	123	25	.	.	PUNCT
bjp-20418	124	1	most	most	ADJ
bjp-20418	124	2	anticancer	anticancer	NOUN
bjp-20418	124	3	drugs	drug	NOUN
bjp-20418	124	4	induce	induce	VERB
bjp-20418	124	5	dna	dna	NOUN
bjp-20418	124	6	damage	damage	NOUN
bjp-20418	124	7	and	and	CCONJ
bjp-20418	124	8	apoptosis	apoptosis	NOUN
bjp-20418	124	9	in	in	ADP
bjp-20418	124	10	by	by	ADP
bjp-20418	124	11	inducing	induce	VERB
bjp-20418	124	12	single	single	ADJ
bjp-20418	124	13	and	and	CCONJ
bjp-20418	124	14	double	double	ADJ
bjp-20418	124	15	strand	strand	NOUN
bjp-20418	124	16	dna	dna	NOUN
bjp-20418	124	17	breaks	break	NOUN
bjp-20418	124	18	(	(	PUNCT
bjp-20418	124	19	ssb	ssb	PROPN
bjp-20418	124	20	and	and	CCONJ
bjp-20418	124	21	dsb	dsb	PROPN
bjp-20418	124	22	,	,	PUNCT
bjp-20418	124	23	respectively	respectively	ADV
bjp-20418	124	24	.	.	PUNCT
bjp-20418	125	1	it	it	PRON
bjp-20418	125	2	is	be	AUX
bjp-20418	125	3	known	know	VERB
bjp-20418	125	4	that	that	SCONJ
bjp-20418	125	5	if	if	SCONJ
bjp-20418	125	6	a	a	DET
bjp-20418	125	7	chromosomal	chromosomal	ADJ
bjp-20418	125	8	break	break	NOUN
bjp-20418	125	9	has	have	AUX
bjp-20418	125	10	been	be	AUX
bjp-20418	125	11	created	create	VERB
bjp-20418	125	12	,	,	PUNCT
bjp-20418	125	13	the	the	DET
bjp-20418	125	14	tumor	tumor	NOUN
bjp-20418	125	15	suppressor	suppressor	NOUN
bjp-20418	125	16	pathway	pathway	NOUN
bjp-20418	125	17	genes	gene	NOUN
bjp-20418	125	18	(	(	PUNCT
bjp-20418	125	19	tsg	tsg	NOUN
bjp-20418	125	20	)	)	PUNCT
bjp-20418	125	21	such	such	ADJ
bjp-20418	125	22	as	as	ADP
bjp-20418	125	23	,	,	PUNCT
bjp-20418	125	24	p53	p53	NOUN
bjp-20418	125	25	level	level	NOUN
bjp-20418	125	26	rises	rise	NOUN
bjp-20418	125	27	,	,	PUNCT
bjp-20418	125	28	gets	get	AUX
bjp-20418	125	29	stabilized	stabilize	VERB
bjp-20418	125	30	and	and	CCONJ
bjp-20418	125	31	induces	induce	VERB
bjp-20418	125	32	cell	cell	NOUN
bjp-20418	125	33	cycle	cycle	NOUN
bjp-20418	125	34	arrest	arrest	NOUN
bjp-20418	125	35	and	and	CCONJ
bjp-20418	125	36	apoptosis	apoptosis	NOUN
bjp-20418	125	37	(	(	PUNCT
bjp-20418	125	38	lai	lai	PROPN
bjp-20418	125	39	et	et	PROPN
bjp-20418	125	40	al	al	PROPN
bjp-20418	125	41	.	.	PROPN
bjp-20418	125	42	,	,	PUNCT
bjp-20418	125	43	2012	2012	NUM
bjp-20418	125	44	)	)	PUNCT
bjp-20418	125	45	.	.	PUNCT
bjp-20418	126	1	although	although	SCONJ
bjp-20418	126	2	,	,	PUNCT
bjp-20418	126	3	further	further	ADJ
bjp-20418	126	4	investigations	investigation	NOUN
bjp-20418	126	5	are	be	AUX
bjp-20418	126	6	required	require	VERB
bjp-20418	126	7	on	on	ADP
bjp-20418	126	8	tsg	tsg	NOUN
bjp-20418	126	9	levels	level	NOUN
bjp-20418	126	10	and	and	CCONJ
bjp-20418	126	11	its	its	PRON
bjp-20418	126	12	relation	relation	NOUN
bjp-20418	126	13	with	with	ADP
bjp-20418	126	14	smad	smad	PROPN
bjp-20418	126	15	signaling	signal	VERB
bjp-20418	126	16	,	,	PUNCT
bjp-20418	126	17	our	our	PRON
bjp-20418	126	18	data	datum	NOUN
bjp-20418	126	19	suggest	suggest	VERB
bjp-20418	126	20	that	that	SCONJ
bjp-20418	126	21	a	a	DET
bjp-20418	126	22	classical	classical	ADJ
bjp-20418	126	23	dna	dna	NOUN
bjp-20418	126	24	damage	damage	NOUN
bjp-20418	126	25	response	response	NOUN
bjp-20418	126	26	mediated	mediate	VERB
bjp-20418	126	27	by	by	ADP
bjp-20418	126	28	tsg	tsg	PROPN
bjp-20418	126	29	to	to	PART
bjp-20418	126	30	cause	cause	VERB
bjp-20418	126	31	apoptosis	apoptosis	NOUN
bjp-20418	126	32	may	may	AUX
bjp-20418	126	33	depend	depend	VERB
bjp-20418	126	34	on	on	ADP
bjp-20418	126	35	smads	smad	NOUN
bjp-20418	126	36	,	,	PUNCT
bjp-20418	126	37	at	at	ADP
bjp-20418	126	38	least	least	ADJ
bjp-20418	126	39	in	in	ADP
bjp-20418	126	40	the	the	DET
bjp-20418	126	41	colon	colon	NOUN
bjp-20418	126	42	cancer	cancer	NOUN
bjp-20418	126	43	suggesting	suggest	VERB
bjp-20418	126	44	for	for	ADP
bjp-20418	126	45	further	further	ADJ
bjp-20418	126	46	modulations	modulation	NOUN
bjp-20418	126	47	of	of	ADP
bjp-20418	126	48	chemotherapy	chemotherapy	NOUN
bjp-20418	126	49	.	.	PUNCT
bjp-20418	127	1	this	this	DET
bjp-20418	127	2	hypothesis	hypothesis	NOUN
bjp-20418	127	3	is	be	AUX
bjp-20418	127	4	further	far	ADV
bjp-20418	127	5	augmented	augment	VERB
bjp-20418	127	6	by	by	ADP
bjp-20418	127	7	strong	strong	ADJ
bjp-20418	127	8	association	association	NOUN
bjp-20418	127	9	of	of	ADP
bjp-20418	127	10	tumor	tumor	NOUN
bjp-20418	127	11	relapse	relapse	NOUN
bjp-20418	127	12	and	and	CCONJ
bjp-20418	127	13	smad	smad	PROPN
bjp-20418	127	14	signaling	signal	VERB
bjp-20418	127	15	conditions	condition	NOUN
bjp-20418	127	16	in	in	ADP
bjp-20418	127	17	patients	patient	NOUN
bjp-20418	127	18	.	.	PUNCT
bjp-20418	128	1	overall	overall	ADV
bjp-20418	128	2	,	,	PUNCT
bjp-20418	128	3	the	the	DET
bjp-20418	128	4	present	present	ADJ
bjp-20418	128	5	data	datum	NOUN
bjp-20418	128	6	suggest	suggest	VERB
bjp-20418	128	7	that	that	SCONJ
bjp-20418	128	8	smad	smad	PROPN
bjp-20418	128	9	signaling	signal	VERB
bjp-20418	128	10	mediate	mediate	VERB
bjp-20418	128	11	the	the	DET
bjp-20418	128	12	drug	drug	NOUN
bjp-20418	128	13	induced	induce	VERB
bjp-20418	128	14	apoptosis	apoptosis	NOUN
bjp-20418	128	15	in	in	ADP
bjp-20418	128	16	colon	colon	NOUN
bjp-20418	128	17	cancer	cancer	NOUN
bjp-20418	128	18	cells	cell	NOUN
bjp-20418	128	19	and	and	CCONJ
bjp-20418	128	20	also	also	ADV
bjp-20418	128	21	possibly	possibly	ADV
bjp-20418	128	22	mediate	mediate	VERB
bjp-20418	128	23	the	the	DET
bjp-20418	128	24	chemotherapy	chemotherapy	NOUN
bjp-20418	128	25	response	response	NOUN
bjp-20418	128	26	in	in	ADP
bjp-20418	128	27	patients	patient	NOUN
bjp-20418	128	28	of	of	ADP
bjp-20418	128	29	colon	colon	NOUN
bjp-20418	128	30	cancer	cancer	NOUN
bjp-20418	128	31	,	,	PUNCT
bjp-20418	128	32	and	and	CCONJ
bjp-20418	128	33	hence	hence	ADV
bjp-20418	128	34	could	could	AUX
bjp-20418	128	35	be	be	AUX
bjp-20418	128	36	used	use	VERB
bjp-20418	128	37	as	as	ADP
bjp-20418	128	38	predictive	predictive	ADJ
bjp-20418	128	39	tool	tool	NOUN
bjp-20418	128	40	and	and	CCONJ
bjp-20418	128	41	design	design	NOUN
bjp-20418	128	42	chemotherapy	chemotherapy	NOUN
bjp-20418	128	43	accordingly	accordingly	ADV
bjp-20418	128	44	.	.	PUNCT
bjp-20418	129	1	contribution	contribution	NOUN
bjp-20418	129	2	first	first	ADJ
bjp-20418	129	3	two	two	NUM
bjp-20418	129	4	authors	author	NOUN
bjp-20418	129	5	contributed	contribute	VERB
bjp-20418	129	6	equally	equally	ADV
bjp-20418	129	7	in	in	ADP
bjp-20418	129	8	the	the	DET
bjp-20418	129	9	study	study	NOUN
bjp-20418	129	10	.	.	PUNCT
bjp-20418	130	1	references	reference	NOUN
bjp-20418	130	2	abdollah	abdollah	ADP
bjp-20418	130	3	s	s	PROPN
bjp-20418	130	4	,	,	PUNCT
bjp-20418	130	5	macias	macias	PROPN
bjp-20418	130	6	-	-	PUNCT
bjp-20418	130	7	silva	silva	PROPN
bjp-20418	130	8	m	m	PROPN
bjp-20418	130	9	,	,	PUNCT
bjp-20418	130	10	tsukazaki	tsukazaki	PROPN
bjp-20418	130	11	t	t	PROPN
bjp-20418	130	12	,	,	PUNCT
bjp-20418	130	13	hayashi	hayashi	PROPN
bjp-20418	130	14	h	h	PROPN
bjp-20418	130	15	,	,	PUNCT
bjp-20418	130	16	attisano	attisano	PROPN
bjp-20418	130	17	l	l	NOUN
bjp-20418	130	18	,	,	PUNCT
bjp-20418	130	19	wran	wran	ADJ
bjp-20418	130	20	jl	jl	PROPN
bjp-20418	130	21	.	.	PUNCT
bjp-20418	131	1	tbri	tbri	PROPN
bjp-20418	131	2	phosphorylation	phosphorylation	NOUN
bjp-20418	131	3	of	of	ADP
bjp-20418	131	4	smad2	smad2	PROPN
bjp-20418	131	5	on	on	ADP
bjp-20418	131	6	ser465	ser465	PROPN
bjp-20418	131	7	and	and	CCONJ
bjp-20418	131	8	ser467	ser467	PROPN
bjp-20418	131	9	is	be	AUX
bjp-20418	131	10	required	require	VERB
bjp-20418	131	11	for	for	ADP
bjp-20418	131	12	smad2	smad2	PROPN
bjp-20418	131	13	-	-	PUNCT
bjp-20418	131	14	smad4	smad4	NOUN
bjp-20418	131	15	complex	complex	ADJ
bjp-20418	131	16	formation	formation	NOUN
bjp-20418	131	17	and	and	CCONJ
bjp-20418	131	18	signaling	signaling	NOUN
bjp-20418	131	19	.	.	PUNCT
bjp-20418	132	1	j	j	PROPN
bjp-20418	132	2	biol	biol	PROPN
bjp-20418	132	3	chem	chem	NOUN
bjp-20418	132	4	.	.	PUNCT
bjp-20418	133	1	1997	1997	NUM
bjp-20418	133	2	;	;	PUNCT
bjp-20418	133	3	272	272	NUM
bjp-20418	133	4	:	:	PUNCT
bjp-20418	133	5	27678	27678	NUM
bjp-20418	133	6	-	-	SYM
bjp-20418	133	7	85	85	NUM
bjp-20418	133	8	.	.	PUNCT
bjp-20418	133	9	chacko	chacko	PROPN
bjp-20418	133	10	bm	bm	PROPN
bjp-20418	133	11	,	,	PUNCT
bjp-20418	133	12	qin	qin	PROPN
bjp-20418	133	13	b	b	PROPN
bjp-20418	133	14	,	,	PUNCT
bjp-20418	133	15	correia	correia	PROPN
bjp-20418	133	16	jj	jj	PROPN
bjp-20418	133	17	,	,	PUNCT
bjp-20418	133	18	lam	lam	PROPN
bjp-20418	133	19	ss	ss	PROPN
bjp-20418	133	20	,	,	PUNCT
bjp-20418	133	21	de	de	PROPN
bjp-20418	133	22	caestecker	caestecker	PROPN
bjp-20418	133	23	mp	mp	PROPN
bjp-20418	133	24	,	,	PUNCT
bjp-20418	133	25	lin	lin	PROPN
bjp-20418	133	26	k.	k.	PROPN
bjp-20418	134	1	the	the	DET
bjp-20418	134	2	l3	l3	PROPN
bjp-20418	134	3	loop	loop	NOUN
bjp-20418	134	4	and	and	CCONJ
bjp-20418	134	5	c	c	NOUN
bjp-20418	134	6	-	-	PUNCT
bjp-20418	134	7	terminal	terminal	ADJ
bjp-20418	134	8	phosphorylation	phosphorylation	NOUN
bjp-20418	134	9	jointly	jointly	ADV
bjp-20418	134	10	define	define	VERB
bjp-20418	134	11	smad	smad	ADJ
bjp-20418	134	12	proteintrimerization	proteintrimerization	NOUN
bjp-20418	134	13	.	.	PUNCT
bjp-20418	135	1	nat	nat	PROPN
bjp-20418	135	2	struct	struct	NOUN
bjp-20418	135	3	biol	biol	PROPN
bjp-20418	135	4	.	.	PUNCT
bjp-20418	136	1	2001	2001	NUM
bjp-20418	136	2	;	;	PUNCT
bjp-20418	136	3	8	8	NUM
bjp-20418	136	4	:	:	SYM
bjp-20418	136	5	248	248	NUM
bjp-20418	136	6	-	-	SYM
bjp-20418	136	7	53	53	NUM
bjp-20418	136	8	.	.	PUNCT
bjp-20418	136	9	chacko	chacko	PROPN
bjp-20418	136	10	bm	bm	PROPN
bjp-20418	136	11	,	,	PUNCT
bjp-20418	136	12	qin	qin	INTJ
bjp-20418	136	13	by	by	ADP
bjp-20418	136	14	,	,	PUNCT
bjp-20418	136	15	tiwari	tiwari	PROPN
bjp-20418	136	16	a	a	PROPN
bjp-20418	136	17	,	,	PUNCT
bjp-20418	136	18	shi	shi	PROPN
bjp-20418	136	19	g	g	PROPN
bjp-20418	136	20	,	,	PUNCT
bjp-20418	136	21	lam	lam	PROPN
bjp-20418	136	22	s	s	PROPN
bjp-20418	136	23	,	,	PUNCT
bjp-20418	136	24	hayward	hayward	PROPN
bjp-20418	136	25	lj	lj	PROPN
bjp-20418	136	26	,	,	PUNCT
bjp-20418	136	27	de	de	PROPN
bjp-20418	136	28	caestecker	caestecker	PROPN
bjp-20418	136	29	m	m	PROPN
bjp-20418	136	30	,	,	PUNCT
bjp-20418	136	31	lin	lin	PROPN
bjp-20418	136	32	k.	k.	PROPN
bjp-20418	136	33	structural	structural	ADJ
bjp-20418	136	34	basis	basis	NOUN
bjp-20418	136	35	of	of	ADP
bjp-20418	136	36	heteromeric	heteromeric	ADJ
bjp-20418	136	37	smad	smad	PROPN
bjp-20418	136	38	protein	protein	NOUN
bjp-20418	136	39	assembly	assembly	NOUN
bjp-20418	136	40	in	in	ADP
bjp-20418	136	41	tgf	tgf	PROPN
bjp-20418	136	42	-	-	PUNCT
bjp-20418	136	43	b	b	NOUN
bjp-20418	136	44	signaling	signaling	NOUN
bjp-20418	136	45	.	.	PUNCT
bjp-20418	137	1	mol	mol	ADP
bjp-20418	137	2	cell	cell	NOUN
bjp-20418	137	3	.	.	PUNCT
bjp-20418	138	1	2004	2004	NUM
bjp-20418	138	2	;	;	PUNCT
bjp-20418	138	3	15	15	NUM
bjp-20418	138	4	:	:	SYM
bjp-20418	138	5	81323	81323	NUM
bjp-20418	138	6	.	.	PUNCT
bjp-20418	139	1	fleming	fleming	PROPN
bjp-20418	139	2	ni	ni	PROPN
bjp-20418	139	3	,	,	PUNCT
bjp-20418	139	4	jorissen	jorissen	PROPN
bjp-20418	139	5	rn	rn	PROPN
bjp-20418	139	6	,	,	PUNCT
bjp-20418	139	7	mouradov	mouradov	PROPN
bjp-20418	139	8	d	d	PROPN
bjp-20418	139	9	,	,	PUNCT
bjp-20418	139	10	christie	christie	PROPN
bjp-20418	139	11	m	m	PROPN
bjp-20418	139	12	,	,	PUNCT
bjp-20418	139	13	sakthianandeswaren	sakthianandeswaren	PROPN
bjp-20418	139	14	a	a	PROPN
bjp-20418	139	15	,	,	PUNCT
bjp-20418	139	16	palmieri	palmieri	PROPN
bjp-20418	139	17	m	m	PROPN
bjp-20418	139	18	,	,	PUNCT
bjp-20418	139	19	day	day	NOUN
bjp-20418	139	20	f	f	PROPN
bjp-20418	139	21	,	,	PUNCT
bjp-20418	139	22	li	li	PROPN
bjp-20418	139	23	s	s	PROPN
bjp-20418	139	24	,	,	PUNCT
bjp-20418	139	25	tsui	tsui	PROPN
bjp-20418	139	26	c	c	PROPN
bjp-20418	139	27	,	,	PUNCT
bjp-20418	139	28	lipton	lipton	PROPN
bjp-20418	139	29	l	l	PROPN
bjp-20418	139	30	,	,	PUNCT
bjp-20418	139	31	desai	desai	PROPN
bjp-20418	139	32	j	j	PROPN
bjp-20418	139	33	,	,	PUNCT
bjp-20418	139	34	jones	jone	VERB
bjp-20418	139	35	it	it	PRON
bjp-20418	139	36	,	,	PUNCT
bjp-20418	139	37	mclaughlin	mclaughlin	PROPN
bjp-20418	139	38	s	s	PROPN
bjp-20418	139	39	,	,	PUNCT
bjp-20418	139	40	ward	ward	PROPN
bjp-20418	139	41	rl	rl	PROPN
bjp-20418	139	42	,	,	PUNCT
bjp-20418	139	43	hawkins	hawkins	PROPN
bjp-20418	139	44	nj	nj	PROPN
bjp-20418	139	45	,	,	PUNCT
bjp-20418	139	46	ruszkiewicz	ruszkiewicz	PROPN
bjp-20418	139	47	ar	ar	PROPN
bjp-20418	139	48	,	,	PUNCT
bjp-20418	139	49	moore	moore	PROPN
bjp-20418	139	50	j	j	PROPN
bjp-20418	139	51	,	,	PUNCT
bjp-20418	139	52	zhu	zhu	PROPN
bjp-20418	139	53	hj	hj	PROPN
bjp-20418	139	54	,	,	PUNCT
bjp-20418	139	55	mariadason	mariadason	PROPN
bjp-20418	139	56	jm	jm	PROPN
bjp-20418	139	57	,	,	PUNCT
bjp-20418	139	58	burgess	burgess	PROPN
bjp-20418	139	59	aw	aw	PROPN
bjp-20418	139	60	,	,	PUNCT
bjp-20418	139	61	busam	busam	PROPN
bjp-20418	140	1	d	d	PROPN
bjp-20418	140	2	,	,	PUNCT
bjp-20418	140	3	zhao	zhao	PROPN
bjp-20418	140	4	q	q	PROPN
bjp-20418	140	5	,	,	PUNCT
bjp-20418	140	6	strausberg	strausberg	PROPN
bjp-20418	140	7	rl	rl	PROPN
bjp-20418	140	8	,	,	PUNCT
bjp-20418	140	9	gibbs	gibbs	PROPN
bjp-20418	140	10	p	p	PROPN
bjp-20418	140	11	,	,	PUNCT
bjp-20418	140	12	sieber	sieber	PROPN
bjp-20418	140	13	om	om	PROPN
bjp-20418	140	14	.	.	PUNCT
bjp-20418	141	1	smad2	smad2	PROPN
bjp-20418	141	2	,	,	PUNCT
bjp-20418	141	3	smad3	smad3	NOUN
bjp-20418	141	4	and	and	CCONJ
bjp-20418	141	5	smad4	smad4	NOUN
bjp-20418	141	6	mutations	mutation	NOUN
bjp-20418	141	7	in	in	ADP
bjp-20418	141	8	colorectal	colorectal	ADJ
bjp-20418	141	9	cancer	cancer	NOUN
bjp-20418	141	10	.	.	PUNCT
bjp-20418	142	1	cancer	cancer	NOUN
bjp-20418	142	2	res	re	NOUN
bjp-20418	142	3	.	.	PUNCT
bjp-20418	142	4	2013	2013	NUM
bjp-20418	142	5	;	;	PUNCT
bjp-20418	142	6	73	73	NUM
bjp-20418	142	7	:	:	PUNCT
bjp-20418	142	8	725	725	NUM
bjp-20418	142	9	-	-	SYM
bjp-20418	142	10	35	35	NUM
bjp-20418	142	11	.	.	PUNCT
bjp-20418	143	1	frederick	frederick	PROPN
bjp-20418	143	2	jp	jp	PROPN
bjp-20418	143	3	,	,	PUNCT
bjp-20418	143	4	wang	wang	PROPN
bjp-20418	143	5	xf	xf	PROPN
bjp-20418	143	6	smads	smad	NOUN
bjp-20418	143	7	"	"	PUNCT
bjp-20418	143	8	freeze	freeze	NOUN
bjp-20418	143	9	"	"	PUNCT
bjp-20418	143	10	when	when	SCONJ
bjp-20418	143	11	they	they	PRON
bjp-20418	143	12	ski	ski	VERB
bjp-20418	143	13	.	.	PUNCT
bjp-20418	144	1	structure	structure	NOUN
bjp-20418	144	2	2002	2002	NUM
bjp-20418	144	3	;	;	PUNCT
bjp-20418	144	4	10	10	NUM
bjp-20418	144	5	:	:	PUNCT
bjp-20418	144	6	1607	1607	NUM
bjp-20418	144	7	-	-	SYM
bjp-20418	144	8	11	11	NUM
bjp-20418	144	9	.	.	PUNCT
bjp-20418	145	1	grau	grau	PROPN
bjp-20418	145	2	am	am	PROPN
bjp-20418	145	3	,	,	PUNCT
bjp-20418	145	4	datta	datta	PROPN
bjp-20418	145	5	pk	pk	PROPN
bjp-20418	145	6	,	,	PUNCT
bjp-20418	145	7	zi	zi	PROPN
bjp-20418	145	8	j	j	PROPN
bjp-20418	145	9	,	,	PUNCT
bjp-20418	145	10	halder	halder	PROPN
bjp-20418	145	11	sk	sk	PROPN
bjp-20418	145	12	,	,	PUNCT
bjp-20418	145	13	beauchamp	beauchamp	PROPN
bjp-20418	145	14	rd	rd	PROPN
bjp-20418	145	15	.	.	PUNCT
bjp-20418	146	1	role	role	NOUN
bjp-20418	146	2	of	of	ADP
bjp-20418	146	3	smad	smad	ADJ
bjp-20418	146	4	proteins	protein	NOUN
bjp-20418	146	5	in	in	ADP
bjp-20418	146	6	the	the	DET
bjp-20418	146	7	regulation	regulation	NOUN
bjp-20418	146	8	of	of	ADP
bjp-20418	146	9	nf	nf	NOUN
bjp-20418	146	10	-	-	PUNCT
bjp-20418	146	11	kappab	kappab	NOUN
bjp-20418	146	12	by	by	ADP
bjp-20418	146	13	tgf	tgf	PROPN
bjp-20418	146	14	-	-	PUNCT
bjp-20418	146	15	beta	beta	NOUN
bjp-20418	146	16	in	in	ADP
bjp-20418	146	17	colon	colon	NOUN
bjp-20418	146	18	cancer	cancer	NOUN
bjp-20418	146	19	cells	cell	NOUN
bjp-20418	146	20	.	.	PUNCT
bjp-20418	147	1	cell	cell	NOUN
bjp-20418	147	2	signal	signal	NOUN
bjp-20418	147	3	.	.	PUNCT
bjp-20418	148	1	2006	2006	NUM
bjp-20418	148	2	;	;	PUNCT
bjp-20418	148	3	18	18	NUM
bjp-20418	148	4	:	:	SYM
bjp-20418	148	5	1041	1041	NUM
bjp-20418	148	6	-	-	SYM
bjp-20418	148	7	50	50	NUM
bjp-20418	148	8	.	.	PUNCT
bjp-20418	149	1	hossain	hossain	PROPN
bjp-20418	149	2	dm	dm	PROPN
bjp-20418	149	3	,	,	PUNCT
bjp-20418	149	4	bhattacharyya	bhattacharyya	PROPN
bjp-20418	149	5	s	s	PROPN
bjp-20418	149	6	,	,	PUNCT
bjp-20418	149	7	das	das	PROPN
bjp-20418	149	8	t	t	PROPN
bjp-20418	149	9	,	,	PUNCT
bjp-20418	149	10	sa	sa	PROPN
bjp-20418	149	11	g.	g.	PROPN
bjp-20418	149	12	curcumin	curcumin	PROPN
bjp-20418	149	13	:	:	PUNCT
bjp-20418	149	14	the	the	DET
bjp-20418	149	15	multi	multi	ADJ
bjp-20418	149	16	-	-	ADJ
bjp-20418	149	17	targeted	targeted	ADJ
bjp-20418	149	18	therapy	therapy	NOUN
bjp-20418	149	19	for	for	ADP
bjp-20418	149	20	cancer	cancer	NOUN
bjp-20418	149	21	regression	regression	NOUN
bjp-20418	149	22	.	.	PUNCT
bjp-20418	150	1	front	front	ADJ
bjp-20418	150	2	biosci	biosci	PROPN
bjp-20418	150	3	(	(	PUNCT
bjp-20418	150	4	schol	schol	PROPN
bjp-20418	150	5	ed	ed	NOUN
bjp-20418	150	6	)	)	PUNCT
bjp-20418	150	7	.	.	PUNCT
bjp-20418	151	1	2012	2012	NUM
bjp-20418	151	2	;	;	PUNCT
bjp-20418	151	3	4	4	NUM
bjp-20418	151	4	:	:	SYM
bjp-20418	151	5	335	335	NUM
bjp-20418	151	6	-	-	SYM
bjp-20418	151	7	55	55	NUM
bjp-20418	151	8	.	.	PUNCT
bjp-20418	152	1	labianca	labianca	PROPN
bjp-20418	152	2	r	r	PROPN
bjp-20418	152	3	,	,	PUNCT
bjp-20418	152	4	beretta	beretta	X
bjp-20418	152	5	gd	gd	NOUN
bjp-20418	152	6	,	,	PUNCT
bjp-20418	152	7	kildani	kildani	PROPN
bjp-20418	152	8	b	b	PROPN
bjp-20418	152	9	,	,	PUNCT
bjp-20418	152	10	milesi	milesi	PROPN
bjp-20418	152	11	l	l	PROPN
bjp-20418	152	12	,	,	PUNCT
bjp-20418	152	13	merlin	merlin	PROPN
bjp-20418	152	14	f	f	PROPN
bjp-20418	152	15	,	,	PUNCT
bjp-20418	152	16	mosconi	mosconi	PROPN
bjp-20418	152	17	s	s	PROPN
bjp-20418	152	18	,	,	PUNCT
bjp-20418	152	19	pessi	pessi	PROPN
bjp-20418	152	20	ma	ma	PROPN
bjp-20418	152	21	,	,	PUNCT
bjp-20418	152	22	prochilo	prochilo	PROPN
bjp-20418	152	23	t	t	PROPN
bjp-20418	152	24	,	,	PUNCT
bjp-20418	152	25	quadri	quadri	PROPN
bjp-20418	152	26	a	a	PROPN
bjp-20418	152	27	,	,	PUNCT
bjp-20418	152	28	gatta	gatta	PROPN
bjp-20418	152	29	g	g	PROPN
bjp-20418	152	30	,	,	PUNCT
bjp-20418	152	31	de	de	X
bjp-20418	152	32	braud	braud	VERB
bjp-20418	152	33	f	f	NUM
bjp-20418	152	34	,	,	PUNCT
bjp-20418	152	35	wils	wil	VERB
bjp-20418	152	36	j.	j.	PROPN
bjp-20418	152	37	colon	colon	NOUN
bjp-20418	152	38	cancer	cancer	NOUN
bjp-20418	152	39	.	.	PUNCT
bjp-20418	153	1	crit	crit	PROPN
bjp-20418	153	2	rev	rev	VERB
bjp-20418	153	3	oncol	oncol	ADJ
bjp-20418	153	4	hematol	hematol	NOUN
bjp-20418	153	5	.	.	PUNCT
bjp-20418	154	1	2010	2010	NUM
bjp-20418	154	2	;	;	PUNCT
bjp-20418	154	3	74	74	NUM
bjp-20418	154	4	:	:	SYM
bjp-20418	154	5	106	106	NUM
bjp-20418	154	6	-	-	SYM
bjp-20418	154	7	33	33	NUM
bjp-20418	154	8	.	.	PUNCT
bjp-20418	155	1	lai	lai	PROPN
bjp-20418	155	2	d	d	PROPN
bjp-20418	155	3	,	,	PUNCT
bjp-20418	155	4	visser	visser	NOUN
bjp-20418	155	5	-	-	PUNCT
bjp-20418	155	6	grieve	grieve	NOUN
bjp-20418	155	7	s	s	PROPN
bjp-20418	155	8	,	,	PUNCT
bjp-20418	155	9	yang	yang	PROPN
bjp-20418	155	10	x.	x.	PROPN
bjp-20418	156	1	tumour	tumour	PROPN
bjp-20418	156	2	suppressor	suppressor	NOUN
bjp-20418	156	3	genes	gene	NOUN
bjp-20418	156	4	in	in	ADP
bjp-20418	156	5	chemotherapeutic	chemotherapeutic	ADJ
bjp-20418	156	6	drug	drug	NOUN
bjp-20418	156	7	response	response	NOUN
bjp-20418	156	8	.	.	PUNCT
bjp-20418	157	1	biosci	biosci	PROPN
bjp-20418	157	2	rep	rep	PROPN
bjp-20418	157	3	.	.	PROPN
bjp-20418	157	4	2012	2012	NUM
bjp-20418	157	5	;	;	PUNCT
bjp-20418	157	6	32	32	NUM
bjp-20418	157	7	:	:	SYM
bjp-20418	157	8	36174	36174	NUM
bjp-20418	157	9	.	.	PUNCT
bjp-20418	158	1	massague	massague	PROPN
bjp-20418	158	2	j.	j.	PROPN
bjp-20418	158	3	tgfb	tgfb	PROPN
bjp-20418	158	4	in	in	ADP
bjp-20418	158	5	cancer	cancer	NOUN
bjp-20418	158	6	.	.	PUNCT
bjp-20418	159	1	cell	cell	NOUN
bjp-20418	159	2	2008	2008	NUM
bjp-20418	159	3	;	;	PUNCT
bjp-20418	159	4	134	134	NUM
bjp-20418	159	5	:	:	PUNCT
bjp-20418	159	6	215	215	NUM
bjp-20418	159	7	-	-	SYM
bjp-20418	159	8	30	30	NUM
bjp-20418	159	9	.	.	PUNCT
bjp-20418	160	1	miyazono	miyazono	X
bjp-20418	161	1	k	k	NOUN
bjp-20418	161	2	,	,	PUNCT
bjp-20418	161	3	ten	ten	NUM
bjp-20418	161	4	dijke	dijke	NOUN
bjp-20418	161	5	p	p	NOUN
bjp-20418	161	6	,	,	PUNCT
bjp-20418	161	7	heldin	heldin	PROPN
bjp-20418	161	8	ch	ch	PROPN
bjp-20418	161	9	.	.	PUNCT
bjp-20418	162	1	tgf	tgf	PROPN
bjp-20418	162	2	-	-	PUNCT
bjp-20418	162	3	beta	beta	NOUN
bjp-20418	162	4	signaling	signaling	NOUN
bjp-20418	162	5	by	by	ADP
bjp-20418	162	6	smad	smad	ADJ
bjp-20418	162	7	proteins	protein	NOUN
bjp-20418	162	8	.	.	PUNCT
bjp-20418	163	1	adv	adv	PROPN
bjp-20418	163	2	immunol	immunol	NOUN
bjp-20418	163	3	.	.	PUNCT
bjp-20418	164	1	2000	2000	NUM
bjp-20418	164	2	;	;	PUNCT
bjp-20418	164	3	75	75	NUM
bjp-20418	164	4	:	:	SYM
bjp-20418	164	5	115	115	NUM
bjp-20418	164	6	-	-	SYM
bjp-20418	164	7	57	57	NUM
bjp-20418	164	8	.	.	PUNCT
bjp-20418	165	1	pasetto	pasetto	PROPN
bjp-20418	165	2	lm	lm	PROPN
bjp-20418	165	3	,	,	PUNCT
bjp-20418	165	4	d'andrea	d'andrea	PROPN
bjp-20418	165	5	mr	mr	PROPN
bjp-20418	165	6	,	,	PUNCT
bjp-20418	165	7	jirillo	jirillo	VERB
bjp-20418	165	8	a	a	PRON
bjp-20418	165	9	,	,	PUNCT
bjp-20418	165	10	rossi	rossi	ADJ
bjp-20418	165	11	e	e	NOUN
bjp-20418	165	12	,	,	PUNCT
bjp-20418	165	13	monfardini	monfardini	PROPN
bjp-20418	165	14	s.	s.	PROPN
bjp-20418	165	15	stable	stable	ADJ
bjp-20418	165	16	disease	disease	NOUN
bjp-20418	165	17	in	in	ADP
bjp-20418	165	18	advanced	advanced	ADJ
bjp-20418	165	19	colorectal	colorectal	ADJ
bjp-20418	165	20	cancer	cancer	NOUN
bjp-20418	165	21	:	:	PUNCT
bjp-20418	165	22	therapeutic	therapeutic	ADJ
bjp-20418	165	23	implications	implication	NOUN
bjp-20418	165	24	.	.	PUNCT
bjp-20418	166	1	anti	anti	ADJ
bjp-20418	166	2	-	-	ADJ
bjp-20418	166	3	cancer	cancer	ADJ
bjp-20418	166	4	res	re	NOUN
bjp-20418	166	5	.	.	PUNCT
bjp-20418	166	6	2006	2006	NUM
bjp-20418	166	7	;	;	PUNCT
bjp-20418	166	8	26	26	NUM
bjp-20418	166	9	:	:	PUNCT
bjp-20418	166	10	511	511	NUM
bjp-20418	166	11	-	-	SYM
bjp-20418	166	12	22	22	NUM
bjp-20418	166	13	.	.	PUNCT
bjp-20418	167	1	sang	sing	VERB
bjp-20418	167	2	hq	hq	PROPN
bjp-20418	167	3	,	,	PUNCT
bjp-20418	167	4	gu	gu	PROPN
bjp-20418	167	5	jf	jf	PROPN
bjp-20418	167	6	,	,	PUNCT
bjp-20418	167	7	yuan	yuan	PROPN
bjp-20418	167	8	jr	jr	PROPN
bjp-20418	167	9	,	,	PUNCT
bjp-20418	167	10	zhang	zhang	PROPN
bjp-20418	167	11	mh	mh	PROPN
bjp-20418	167	12	,	,	PUNCT
bjp-20418	167	13	jia	jia	PROPN
bjp-20418	167	14	xb	xb	PROPN
bjp-20418	167	15	,	,	PUNCT
bjp-20418	167	16	feng	feng	PROPN
bjp-20418	167	17	l.	l.	PROPN
bjp-20418	167	18	the	the	DET
bjp-20418	167	19	protective	protective	ADJ
bjp-20418	167	20	effect	effect	NOUN
bjp-20418	167	21	of	of	ADP
bjp-20418	167	22	smilax	smilax	NOUN
bjp-20418	167	23	glabra	glabra	NOUN
bjp-20418	167	24	extract	extract	VERB
bjp-20418	167	25	on	on	ADP
bjp-20418	167	26	advanced	advanced	ADJ
bjp-20418	167	27	glycation	glycation	NOUN
bjp-20418	167	28	end	end	NOUN
bjp-20418	167	29	products	product	NOUN
bjp-20418	167	30	-	-	PUNCT
bjp-20418	167	31	induced	induce	VERB
bjp-20418	167	32	endothelial	endothelial	ADJ
bjp-20418	167	33	dysfunction	dysfunction	NOUN
bjp-20418	167	34	in	in	ADP
bjp-20418	167	35	huvecs	huvec	NOUN
bjp-20418	167	36	via	via	ADP
bjp-20418	167	37	rage	rage	NOUN
bjp-20418	167	38	-	-	PUNCT
bjp-20418	167	39	erk1/2	erk1/2	NOUN
bjp-20418	167	40	-	-	PUNCT
bjp-20418	167	41	nf	nf	NOUN
bjp-20418	167	42	-	-	PUNCT
bjp-20418	167	43	κb	κb	NOUN
bjp-20418	167	44	pathway	pathway	NOUN
bjp-20418	167	45	.	.	PUNCT
bjp-20418	168	1	j	j	PROPN
bjp-20418	168	2	ethnopharmacol	ethnopharmacol	PROPN
bjp-20418	168	3	.	.	PUNCT
bjp-20418	169	1	2014	2014	NUM
bjp-20418	169	2	;	;	PUNCT
bjp-20418	169	3	155	155	NUM
bjp-20418	169	4	:	:	SYM
bjp-20418	169	5	785	785	NUM
bjp-20418	169	6	-	-	SYM
bjp-20418	169	7	95	95	NUM
bjp-20418	169	8	.	.	PUNCT
bjp-20418	170	1	souchelnytskyi	souchelnytskyi	PROPN
bjp-20418	170	2	s	s	PART
bjp-20418	170	3	,	,	PUNCT
bjp-20418	170	4	tamaki	tamaki	PROPN
bjp-20418	170	5	k	k	PROPN
bjp-20418	170	6	,	,	PUNCT
bjp-20418	170	7	engstrom	engstrom	ADP
bjp-20418	170	8	u	u	NOUN
bjp-20418	170	9	,	,	PUNCT
bjp-20418	170	10	wernstedt	wernstedt	ADJ
bjp-20418	170	11	c	c	NOUN
bjp-20418	170	12	,	,	PUNCT
bjp-20418	170	13	ten	ten	NUM
bjp-20418	170	14	dijke	dijke	NOUN
bjp-20418	170	15	p	p	NOUN
bjp-20418	170	16	,	,	PUNCT
bjp-20418	170	17	heldin	heldin	PROPN
bjp-20418	170	18	ch	ch	PROPN
bjp-20418	170	19	.	.	PROPN
bjp-20418	170	20	phosphorylation	phosphorylation	NOUN
bjp-20418	170	21	of	of	ADP
bjp-20418	170	22	ser465	ser465	NOUN
bjp-20418	170	23	and	and	CCONJ
bjp-20418	170	24	ser467	ser467	PROPN
bjp-20418	170	25	in	in	ADP
bjp-20418	170	26	the	the	DET
bjp-20418	170	27	cterminus	cterminus	NOUN
bjp-20418	170	28	of	of	ADP
bjp-20418	170	29	smad2	smad2	PROPN
bjp-20418	170	30	mediates	mediate	NOUN
bjp-20418	170	31	interaction	interaction	NOUN
bjp-20418	170	32	with	with	ADP
bjp-20418	170	33	smad4	smad4	NOUN
bjp-20418	170	34	and	and	CCONJ
bjp-20418	170	35	is	be	AUX
bjp-20418	170	36	required	require	VERB
bjp-20418	170	37	for	for	ADP
bjp-20418	170	38	transforming	transform	VERB
bjp-20418	170	39	growth	growth	NOUN
bjp-20418	170	40	factor	factor	NOUN
bjp-20418	170	41	-	-	PUNCT
bjp-20418	170	42	beta	beta	NOUN
bjp-20418	170	43	signaling	signaling	NOUN
bjp-20418	170	44	.	.	PUNCT
bjp-20418	171	1	j	j	PROPN
bjp-20418	171	2	biol	biol	PROPN
bjp-20418	171	3	chem	chem	NOUN
bjp-20418	171	4	.	.	PUNCT
bjp-20418	172	1	1997	1997	NUM
bjp-20418	172	2	;	;	PUNCT
bjp-20418	172	3	272	272	NUM
bjp-20418	172	4	:	:	PUNCT
bjp-20418	172	5	28107	28107	NUM
bjp-20418	172	6	-	-	SYM
bjp-20418	172	7	15	15	NUM
bjp-20418	172	8	.	.	PUNCT
bjp-20418	173	1	shi	shi	PROPN
bjp-20418	173	2	y	y	PROPN
bjp-20418	173	3	,	,	PUNCT
bjp-20418	173	4	hata	hata	VERB
bjp-20418	173	5	a	a	PRON
bjp-20418	173	6	,	,	PUNCT
bjp-20418	173	7	lo	lo	PROPN
bjp-20418	173	8	rs	rs	NOUN
bjp-20418	173	9	,	,	PUNCT
bjp-20418	173	10	massague	massague	PROPN
bjp-20418	173	11	j	j	PROPN
bjp-20418	173	12	,	,	PUNCT
bjp-20418	173	13	pavletich	pavletich	PRON
bjp-20418	173	14	np	np	PROPN
bjp-20418	173	15	.	.	PUNCT
bjp-20418	174	1	a	a	DET
bjp-20418	174	2	structural	structural	ADJ
bjp-20418	174	3	basis	basis	NOUN
bjp-20418	174	4	formutational	formutational	ADJ
bjp-20418	174	5	inactivation	inactivation	NOUN
bjp-20418	174	6	of	of	ADP
bjp-20418	174	7	the	the	DET
bjp-20418	174	8	tumour	tumour	NOUN
bjp-20418	174	9	suppressor	suppressor	NOUN
bjp-20418	174	10	smad4	smad4	PROPN
bjp-20418	174	11	.	.	PUNCT
bjp-20418	174	12	nature	nature	NOUN
bjp-20418	174	13	1997	1997	NUM
bjp-20418	174	14	;	;	PUNCT
bjp-20418	174	15	388	388	NUM
bjp-20418	174	16	:	:	PUNCT
bjp-20418	174	17	87	87	NUM
bjp-20418	174	18	-	-	SYM
bjp-20418	174	19	93	93	NUM
bjp-20418	174	20	.	.	PUNCT
bjp-20418	175	1	zhang	zhang	PROPN
bjp-20418	175	2	l	l	PROPN
bjp-20418	175	3	,	,	PUNCT
bjp-20418	175	4	zhou	zhou	PROPN
bjp-20418	175	5	f	f	X
bjp-20418	175	6	,	,	PUNCT
bjp-20418	175	7	ten	ten	NUM
bjp-20418	175	8	dijke	dijke	NOUN
bjp-20418	175	9	p.	p.	NOUN
bjp-20418	175	10	signaling	signal	VERB
bjp-20418	175	11	interplay	interplay	NOUN
bjp-20418	175	12	between	between	ADP
bjp-20418	175	13	transforming	transform	VERB
bjp-20418	175	14	growth	growth	NOUN
bjp-20418	175	15	factor	factor	NOUN
bjp-20418	175	16	-	-	PUNCT
bjp-20418	175	17	β	β	NOUN
bjp-20418	175	18	receptor	receptor	NOUN
bjp-20418	175	19	and	and	CCONJ
bjp-20418	175	20	pi3k	pi3k	PROPN
bjp-20418	175	21	/	/	SYM
bjp-20418	175	22	akt	akt	PROPN
bjp-20418	175	23	pathways	pathway	NOUN
bjp-20418	175	24	in	in	ADP
bjp-20418	175	25	cancer	cancer	NOUN
bjp-20418	175	26	.	.	PUNCT
bjp-20418	176	1	trends	trend	NOUN
bjp-20418	176	2	biochem	biochem	PROPN
bjp-20418	176	3	sci	sci	PROPN
bjp-20418	176	4	.	.	PROPN
bjp-20418	176	5	2013	2013	NUM
bjp-20418	176	6	;	;	PUNCT
bjp-20418	176	7	38	38	NUM
bjp-20418	176	8	:	:	PUNCT
bjp-20418	176	9	612	612	NUM
bjp-20418	176	10	-	-	SYM
bjp-20418	176	11	20	20	NUM
bjp-20418	176	12	.	.	PUNCT
bjp-20418	177	1	544	544	NUM
bjp-20418	177	2	bangladesh	bangladesh	NOUN
bjp-20418	177	3	j	j	PROPN
bjp-20418	177	4	pharmacol	pharmacol	PROPN
bjp-20418	177	5	2014	2014	NUM
bjp-20418	177	6	;	;	PUNCT
bjp-20418	177	7	9	9	NUM
bjp-20418	177	8	:	:	SYM
bjp-20418	177	9	539	539	NUM
bjp-20418	177	10	-	-	SYM
bjp-20418	177	11	544	544	NUM
bjp-20418	177	12	author	author	NOUN
bjp-20418	177	13	info	info	NOUN
bjp-20418	177	14	qing	qe	VERB
bjp-20418	177	15	bo	bo	PROPN
bjp-20418	177	16	yu	yu	PROPN
bjp-20418	177	17	(	(	PUNCT
bjp-20418	177	18	principal	principal	ADJ
bjp-20418	177	19	contact	contact	NOUN
bjp-20418	177	20	)	)	PUNCT
bjp-20418	177	21	e	e	NOUN
bjp-20418	177	22	-	-	NOUN
bjp-20418	177	23	mail	mail	NOUN
bjp-20418	177	24	:	:	PUNCT
bjp-20418	178	1	yuqingbo8133@hotmail.com	yuqingbo8133@hotmail.com	X
bjp-20418	178	2	contribution	contribution	PROPN
bjp-20418	178	3	:	:	PUNCT
bjp-20418	178	4	references	reference	NOUN
bjp-20418	178	5	:	:	PUNCT
bjp-20418	178	6	dateprinted	dateprinte	VERB
bjp-20418	178	7	:	:	PUNCT
bjp-20418	178	8	this	this	DET
bjp-20418	178	9	article	article	NOUN
bjp-20418	178	10	was	be	AUX
bjp-20418	178	11	downloaded	download	VERB
bjp-20418	178	12	by	by	ADP
bjp-20418	178	13	you	you	PRON
bjp-20418	178	14	on	on	ADP
bjp-20418	178	15	:	:	PUNCT
bjp-20418	178	16	oct	oct	PROPN
bjp-20418	178	17	05	05	NUM
bjp-20418	178	18	,	,	PUNCT
bjp-20418	178	19	2018	2018	NUM