id	sid	tid	token	lemma	pos
bjp-23565	1	1	bangladesh	bangladesh	PROPN
bjp-23565	1	2	journal	journal	PROPN
bjp-23565	1	3	of	of	ADP
bjp-23565	1	4	pharmacology	pharmacology	NOUN
bjp-23565	1	5	research	research	NOUN
bjp-23565	1	6	article	article	NOUN
bjp-23565	1	7	paclitaxel	paclitaxel	NOUN
bjp-23565	1	8	and	and	CCONJ
bjp-23565	1	9	trastuzumab	trastuzumab	NOUN
bjp-23565	1	10	treatment	treatment	NOUN
bjp-23565	1	11	affects	affect	VERB
bjp-23565	1	12	insulin	insulin	NOUN
bjp-23565	1	13	growth	growth	NOUN
bjp-23565	1	14	factor	factor	NOUN
bjp-23565	1	15	i	i	PRON
bjp-23565	1	16	expression	expression	NOUN
bjp-23565	1	17	in	in	ADP
bjp-23565	1	18	breast	breast	NOUN
bjp-23565	1	19	cancer	cancer	NOUN
bjp-23565	1	20	cell	cell	NOUN
bjp-23565	1	21	lines	line	NOUN
bjp-23565	1	22	bjp	bjp	PROPN
bjp-23565	1	23	introduction	introduction	NOUN
bjp-23565	1	24	insulin	insulin	NOUN
bjp-23565	1	25	-	-	PUNCT
bjp-23565	1	26	like	like	ADJ
bjp-23565	1	27	growth	growth	NOUN
bjp-23565	1	28	factor	factor	NOUN
bjp-23565	1	29	i	i	PRON
bjp-23565	1	30	receptor	receptor	NOUN
bjp-23565	1	31	(	(	PUNCT
bjp-23565	1	32	igf-1r	igf-1r	PROPN
bjp-23565	1	33	)	)	PUNCT
bjp-23565	1	34	is	be	AUX
bjp-23565	1	35	a	a	DET
bjp-23565	1	36	receptor	receptor	NOUN
bjp-23565	1	37	tyrosine	tyrosine	NOUN
bjp-23565	1	38	kinase	kinase	PROPN
bjp-23565	1	39	(	(	PUNCT
bjp-23565	1	40	rtk	rtk	NOUN
bjp-23565	1	41	)	)	PUNCT
bjp-23565	1	42	protein	protein	NOUN
bjp-23565	1	43	overexpressed	overexpresse	VERB
bjp-23565	1	44	(	(	PUNCT
bjp-23565	1	45	about	about	ADV
bjp-23565	1	46	70	70	NUM
bjp-23565	1	47	%	%	NOUN
bjp-23565	1	48	)	)	PUNCT
bjp-23565	1	49	in	in	ADP
bjp-23565	1	50	breast	breast	NOUN
bjp-23565	1	51	cancer	cancer	NOUN
bjp-23565	1	52	cells	cell	NOUN
bjp-23565	1	53	(	(	PUNCT
bjp-23565	1	54	nielson	nielson	PROPN
bjp-23565	1	55	et	et	PROPN
bjp-23565	1	56	al	al	PROPN
bjp-23565	1	57	.	.	PROPN
bjp-23565	1	58	,	,	PUNCT
bjp-23565	1	59	2004	2004	NUM
bjp-23565	1	60	;	;	PUNCT
bjp-23565	1	61	sachdev	sachdev	PROPN
bjp-23565	1	62	et	et	PROPN
bjp-23565	1	63	al	al	PROPN
bjp-23565	1	64	.	.	PROPN
bjp-23565	1	65	,	,	PUNCT
bjp-23565	1	66	2004	2004	NUM
bjp-23565	1	67	)	)	PUNCT
bjp-23565	1	68	.	.	PUNCT
bjp-23565	2	1	igf-1r	igf-1r	PROPN
bjp-23565	2	2	plays	play	VERB
bjp-23565	2	3	an	an	DET
bjp-23565	2	4	essential	essential	ADJ
bjp-23565	2	5	role	role	NOUN
bjp-23565	2	6	growth	growth	NOUN
bjp-23565	2	7	and	and	CCONJ
bjp-23565	2	8	maintenance	maintenance	NOUN
bjp-23565	2	9	of	of	ADP
bjp-23565	2	10	cancer	cancer	NOUN
bjp-23565	2	11	cells	cell	NOUN
bjp-23565	2	12	and	and	CCONJ
bjp-23565	2	13	found	find	VERB
bjp-23565	2	14	to	to	PART
bjp-23565	2	15	be	be	AUX
bjp-23565	2	16	a	a	DET
bjp-23565	2	17	target	target	NOUN
bjp-23565	2	18	for	for	ADP
bjp-23565	2	19	cancer	cancer	NOUN
bjp-23565	2	20	treatment	treatment	NOUN
bjp-23565	2	21	.	.	PUNCT
bjp-23565	3	1	igf-1r	igf-1r	PROPN
bjp-23565	3	2	is	be	AUX
bjp-23565	3	3	one	one	NUM
bjp-23565	3	4	of	of	ADP
bjp-23565	3	5	such	such	ADJ
bjp-23565	3	6	receptors	receptor	NOUN
bjp-23565	3	7	which	which	PRON
bjp-23565	3	8	consists	consist	VERB
bjp-23565	3	9	of	of	ADP
bjp-23565	3	10	two	two	NUM
bjp-23565	3	11	α	α	NOUN
bjp-23565	3	12	-	-	PUNCT
bjp-23565	3	13	subunits	subunit	NOUN
bjp-23565	3	14	involved	involve	VERB
bjp-23565	3	15	in	in	ADP
bjp-23565	3	16	ligand	ligand	NOUN
bjp-23565	3	17	binding	bind	VERB
bjp-23565	3	18	outside	outside	ADP
bjp-23565	3	19	the	the	DET
bjp-23565	3	20	cell	cell	NOUN
bjp-23565	3	21	and	and	CCONJ
bjp-23565	3	22	two	two	NUM
bjp-23565	3	23	β	β	NOUN
bjp-23565	3	24	-	-	NOUN
bjp-23565	3	25	subunits	subunit	NOUN
bjp-23565	3	26	with	with	ADP
bjp-23565	3	27	a	a	DET
bjp-23565	3	28	tyrosine	tyrosine	NOUN
bjp-23565	3	29	kinase	kinase	NOUN
bjp-23565	3	30	,	,	PUNCT
bjp-23565	4	1	tm	tm	DET
bjp-23565	4	2	domain	domain	NOUN
bjp-23565	4	3	and	and	CCONJ
bjp-23565	4	4	carboxyl	carboxyl	NOUN
bjp-23565	4	5	terminal	terminal	ADJ
bjp-23565	4	6	domain	domain	NOUN
bjp-23565	4	7	(	(	PUNCT
bjp-23565	4	8	ullrich	ullrich	PROPN
bjp-23565	4	9	et	et	PROPN
bjp-23565	4	10	al	al	PROPN
bjp-23565	4	11	.	.	PROPN
bjp-23565	4	12	,	,	PUNCT
bjp-23565	4	13	1986	1986	NUM
bjp-23565	4	14	)	)	PUNCT
bjp-23565	4	15	.	.	PUNCT
bjp-23565	5	1	the	the	DET
bjp-23565	5	2	tyrosine	tyrosine	NOUN
bjp-23565	5	3	residues	residue	VERB
bjp-23565	5	4	in	in	ADP
bjp-23565	5	5	the	the	DET
bjp-23565	5	6	tyrosine	tyrosine	NOUN
bjp-23565	5	7	kinase	kinase	PROPN
bjp-23565	5	8	domain	domain	NOUN
bjp-23565	5	9	gets	get	AUX
bjp-23565	5	10	phosphorylated	phosphorylate	VERB
bjp-23565	5	11	due	due	ADP
bjp-23565	5	12	to	to	ADP
bjp-23565	5	13	the	the	DET
bjp-23565	5	14	interaction	interaction	NOUN
bjp-23565	5	15	between	between	ADP
bjp-23565	5	16	the	the	DET
bjp-23565	5	17	ligand	ligand	NOUN
bjp-23565	5	18	and	and	CCONJ
bjp-23565	5	19	the	the	DET
bjp-23565	5	20	receptor	receptor	NOUN
bjp-23565	5	21	.	.	PUNCT
bjp-23565	6	1	the	the	DET
bjp-23565	6	2	role	role	NOUN
bjp-23565	6	3	of	of	ADP
bjp-23565	6	4	igf-1	igf-1	NOUN
bjp-23565	6	5	in	in	ADP
bjp-23565	6	6	breast	breast	NOUN
bjp-23565	6	7	cancer	cancer	NOUN
bjp-23565	6	8	has	have	AUX
bjp-23565	6	9	been	be	AUX
bjp-23565	6	10	proved	prove	VERB
bjp-23565	6	11	by	by	ADP
bjp-23565	6	12	several	several	ADJ
bjp-23565	6	13	clinical	clinical	ADJ
bjp-23565	6	14	studies	study	NOUN
bjp-23565	6	15	(	(	PUNCT
bjp-23565	6	16	li	li	PROPN
bjp-23565	6	17	et	et	PROPN
bjp-23565	6	18	al	al	PROPN
bjp-23565	6	19	.	.	PROPN
bjp-23565	6	20	,	,	PUNCT
bjp-23565	6	21	2001	2001	NUM
bjp-23565	6	22	;	;	PUNCT
bjp-23565	6	23	michels	michel	NOUN
bjp-23565	6	24	and	and	CCONJ
bjp-23565	6	25	willett	willett	NOUN
bjp-23565	6	26	,	,	PUNCT
bjp-23565	6	27	2004	2004	NUM
bjp-23565	6	28	)	)	PUNCT
bjp-23565	6	29	.	.	PUNCT
bjp-23565	7	1	in	in	ADP
bjp-23565	7	2	recent	recent	ADJ
bjp-23565	7	3	years	year	NOUN
bjp-23565	7	4	,	,	PUNCT
bjp-23565	7	5	the	the	DET
bjp-23565	7	6	number	number	NOUN
bjp-23565	7	7	of	of	ADP
bjp-23565	7	8	studies	study	NOUN
bjp-23565	7	9	have	have	AUX
bjp-23565	7	10	been	be	AUX
bjp-23565	7	11	on	on	ADP
bjp-23565	7	12	the	the	DET
bjp-23565	7	13	rise	rise	NOUN
bjp-23565	7	14	to	to	PART
bjp-23565	7	15	elucidate	elucidate	VERB
bjp-23565	7	16	the	the	DET
bjp-23565	7	17	igf1	igf1	PROPN
bjp-23565	7	18	function	function	NOUN
bjp-23565	7	19	with	with	ADP
bjp-23565	7	20	breast	breast	NOUN
bjp-23565	7	21	cancer	cancer	NOUN
bjp-23565	7	22	(	(	PUNCT
bjp-23565	7	23	sarfestein	sarfestein	NOUN
bjp-23565	7	24	et	et	PROPN
bjp-23565	7	25	al	al	PROPN
bjp-23565	7	26	.	.	PROPN
bjp-23565	7	27	,	,	PUNCT
bjp-23565	7	28	2012	2012	NUM
bjp-23565	7	29	;	;	PUNCT
bjp-23565	7	30	becker	becker	PROPN
bjp-23565	7	31	et	et	PROPN
bjp-23565	7	32	al	al	PROPN
bjp-23565	7	33	.	.	PROPN
bjp-23565	7	34	,	,	PUNCT
bjp-23565	7	35	2011	2011	NUM
bjp-23565	7	36	;	;	PUNCT
bjp-23565	7	37	kang	kang	PROPN
bjp-23565	7	38	et	et	PROPN
bjp-23565	7	39	al	al	PROPN
bjp-23565	7	40	.	.	PROPN
bjp-23565	7	41	,	,	PUNCT
bjp-23565	7	42	2012	2012	NUM
bjp-23565	7	43	)	)	PUNCT
bjp-23565	7	44	.	.	PUNCT
bjp-23565	8	1	erk	erk	PROPN
bjp-23565	8	2	and	and	CCONJ
bjp-23565	8	3	akt	akt	PROPN
bjp-23565	8	4	were	be	AUX
bjp-23565	8	5	the	the	DET
bjp-23565	8	6	two	two	NUM
bjp-23565	8	7	main	main	ADJ
bjp-23565	8	8	pathways	pathway	NOUN
bjp-23565	8	9	for	for	ADP
bjp-23565	8	10	igf-1	igf-1	NOUN
bjp-23565	8	11	receptor	receptor	NOUN
bjp-23565	8	12	transduction	transduction	NOUN
bjp-23565	8	13	(	(	PUNCT
bjp-23565	8	14	le	le	X
bjp-23565	8	15	roith	roith	ADP
bjp-23565	8	16	et	et	PROPN
bjp-23565	8	17	al	al	PROPN
bjp-23565	8	18	.	.	PROPN
bjp-23565	8	19	,	,	PUNCT
bjp-23565	8	20	2001	2001	NUM
bjp-23565	8	21	;	;	PUNCT
bjp-23565	8	22	jones	jones	PROPN
bjp-23565	8	23	and	and	CCONJ
bjp-23565	8	24	clemmons	clemmons	PROPN
bjp-23565	8	25	,	,	PUNCT
bjp-23565	8	26	1995	1995	NUM
bjp-23565	8	27	;	;	PUNCT
bjp-23565	8	28	menu	menu	NOUN
bjp-23565	8	29	et	et	PROPN
bjp-23565	8	30	al	al	PROPN
bjp-23565	8	31	.	.	PROPN
bjp-23565	8	32	,	,	PUNCT
bjp-23565	8	33	2004	2004	NUM
bjp-23565	8	34	)	)	PUNCT
bjp-23565	8	35	.	.	PUNCT
bjp-23565	9	1	in	in	ADP
bjp-23565	9	2	one	one	NUM
bjp-23565	9	3	of	of	ADP
bjp-23565	9	4	the	the	DET
bjp-23565	9	5	pathway	pathway	NOUN
bjp-23565	9	6	,	,	PUNCT
bjp-23565	9	7	igf-1	igf-1	PRON
bjp-23565	9	8	activates	activate	VERB
bjp-23565	9	9	raf	raf	PROPN
bjp-23565	9	10	and	and	CCONJ
bjp-23565	9	11	mitogen	mitogen	NOUN
bjp-23565	9	12	-	-	PUNCT
bjp-23565	9	13	activated	activate	VERB
bjp-23565	9	14	protein	protein	NOUN
bjp-23565	9	15	kinase	kinase	NOUN
bjp-23565	9	16	(	(	PUNCT
bjp-23565	9	17	mapk	mapk	NOUN
bjp-23565	9	18	)	)	PUNCT
bjp-23565	9	19	resulting	result	VERB
bjp-23565	9	20	in	in	ADP
bjp-23565	9	21	the	the	DET
bjp-23565	9	22	transcription	transcription	NOUN
bjp-23565	9	23	of	of	ADP
bjp-23565	9	24	proliferative	proliferative	ADJ
bjp-23565	9	25	genes	gene	NOUN
bjp-23565	9	26	whereas	whereas	SCONJ
bjp-23565	9	27	the	the	DET
bjp-23565	9	28	second	second	ADJ
bjp-23565	9	29	pathway	pathway	NOUN
bjp-23565	9	30	involving	involve	VERB
bjp-23565	9	31	phosphoinositide	phosphoinositide	ADJ
bjp-23565	9	32	3	3	PROPN
bjp-23565	9	33	-	-	PUNCT
bjp-23565	9	34	kinase	kinase	NOUN
bjp-23565	9	35	(	(	PUNCT
bjp-23565	9	36	pi3k)/akt	pi3k)/akt	PROPN
bjp-23565	9	37	is	be	AUX
bjp-23565	9	38	responsible	responsible	ADJ
bjp-23565	9	39	for	for	ADP
bjp-23565	9	40	cell	cell	NOUN
bjp-23565	9	41	survival	survival	NOUN
bjp-23565	9	42	and	and	CCONJ
bjp-23565	9	43	signaling	signaling	NOUN
bjp-23565	9	44	of	of	ADP
bjp-23565	9	45	anti	anti	ADJ
bjp-23565	9	46	-	-	ADJ
bjp-23565	9	47	apoptosis	apoptosis	ADJ
bjp-23565	9	48	(	(	PUNCT
bjp-23565	9	49	manning	manning	NOUN
bjp-23565	9	50	and	and	CCONJ
bjp-23565	9	51	cantley	cantley	NOUN
bjp-23565	9	52	,	,	PUNCT
bjp-23565	9	53	2007	2007	NUM
bjp-23565	9	54	)	)	PUNCT
bjp-23565	9	55	.	.	PUNCT
bjp-23565	10	1	the	the	DET
bjp-23565	10	2	significance	significance	NOUN
bjp-23565	10	3	of	of	ADP
bjp-23565	10	4	igfs	igfs	NOUN
bjp-23565	10	5	in	in	ADP
bjp-23565	10	6	growth	growth	NOUN
bjp-23565	10	7	regulation	regulation	NOUN
bjp-23565	10	8	of	of	ADP
bjp-23565	10	9	breast	breast	NOUN
bjp-23565	10	10	cancer	cancer	NOUN
bjp-23565	10	11	cell	cell	NOUN
bjp-23565	10	12	lines	line	NOUN
bjp-23565	10	13	have	have	AUX
bjp-23565	10	14	been	be	AUX
bjp-23565	10	15	well	well	ADV
bjp-23565	10	16	studies	study	NOUN
bjp-23565	10	17	.	.	PUNCT
bjp-23565	11	1	it	it	PRON
bjp-23565	11	2	also	also	ADV
bjp-23565	11	3	improves	improve	VERB
bjp-23565	11	4	the	the	DET
bjp-23565	11	5	cell	cell	NOUN
bjp-23565	11	6	survival	survival	NOUN
bjp-23565	11	7	rate	rate	NOUN
bjp-23565	11	8	of	of	ADP
bjp-23565	11	9	cancer	cancer	NOUN
bjp-23565	11	10	cells	cell	NOUN
bjp-23565	11	11	.	.	PUNCT
bjp-23565	12	1	so	so	ADV
bjp-23565	12	2	,	,	PUNCT
bjp-23565	12	3	combining	combine	VERB
bjp-23565	12	4	igf	igf	NOUN
bjp-23565	12	5	inhibition	inhibition	NOUN
bjp-23565	12	6	with	with	ADP
bjp-23565	12	7	conventional	conventional	ADJ
bjp-23565	12	8	cytotoxic	cytotoxic	ADJ
bjp-23565	12	9	drug	drug	NOUN
bjp-23565	12	10	treatment	treatment	NOUN
bjp-23565	12	11	will	will	AUX
bjp-23565	12	12	have	have	VERB
bjp-23565	12	13	synergistic	synergistic	ADJ
bjp-23565	12	14	effect	effect	NOUN
bjp-23565	12	15	and	and	CCONJ
bjp-23565	12	16	enhance	enhance	VERB
bjp-23565	12	17	the	the	DET
bjp-23565	12	18	breast	breast	NOUN
bjp-23565	12	19	cancer	cancer	NOUN
bjp-23565	12	20	treatment	treatment	NOUN
bjp-23565	12	21	.	.	PUNCT
bjp-23565	13	1	pertuzumab	pertuzumab	PROPN
bjp-23565	13	2	was	be	AUX
bjp-23565	13	3	used	use	VERB
bjp-23565	13	4	with	with	ADP
bjp-23565	13	5	trastuzumab	trastuzumab	NOUN
bjp-23565	13	6	and	and	CCONJ
bjp-23565	13	7	docetaxel	docetaxel	NOUN
bjp-23565	13	8	for	for	ADP
bjp-23565	13	9	patients	patient	NOUN
bjp-23565	13	10	having	have	VERB
bjp-23565	13	11	metastatic	metastatic	ADJ
bjp-23565	13	12	breast	breast	NOUN
bjp-23565	13	13	cancer	cancer	NOUN
bjp-23565	13	14	with	with	ADP
bjp-23565	13	15	positive	positive	ADJ
bjp-23565	13	16	human	human	ADJ
bjp-23565	13	17	epidermal	epidermal	ADJ
bjp-23565	13	18	growth	growth	NOUN
bjp-23565	13	19	factor	factor	NOUN
bjp-23565	13	20	receptor	receptor	NOUN
bjp-23565	13	21	2	2	NUM
bjp-23565	13	22	(	(	PUNCT
bjp-23565	13	23	her2	her2	PROPN
bjp-23565	13	24	)	)	PUNCT
bjp-23565	13	25	and	and	CCONJ
bjp-23565	13	26	without	without	ADP
bjp-23565	13	27	prior	prior	ADJ
bjp-23565	13	28	treatment	treatment	NOUN
bjp-23565	13	29	(	(	PUNCT
bjp-23565	13	30	baselga	baselga	NOUN
bjp-23565	13	31	et	et	PROPN
bjp-23565	13	32	al	al	PROPN
bjp-23565	13	33	.	.	PROPN
bjp-23565	13	34	,	,	PUNCT
bjp-23565	13	35	2012	2012	NUM
bjp-23565	13	36	)	)	PUNCT
bjp-23565	13	37	.	.	PUNCT
bjp-23565	14	1	paclitaxel	paclitaxel	PROPN
bjp-23565	14	2	,	,	PUNCT
bjp-23565	14	3	a	a	DET
bjp-23565	14	4	drug	drug	NOUN
bjp-23565	14	5	obtained	obtain	VERB
bjp-23565	14	6	from	from	ADP
bjp-23565	14	7	bark	bark	NOUN
bjp-23565	14	8	of	of	ADP
bjp-23565	14	9	western	western	ADJ
bjp-23565	14	10	yew	yew	NOUN
bjp-23565	14	11	tree	tree	NOUN
bjp-23565	14	12	is	be	AUX
bjp-23565	14	13	used	use	VERB
bjp-23565	14	14	for	for	ADP
bjp-23565	14	15	treating	treat	VERB
bjp-23565	14	16	various	various	ADJ
bjp-23565	14	17	a	a	DET
bjp-23565	14	18	journal	journal	NOUN
bjp-23565	14	19	of	of	ADP
bjp-23565	14	20	the	the	DET
bjp-23565	14	21	bangladesh	bangladesh	NOUN
bjp-23565	14	22	pharmacological	pharmacological	ADJ
bjp-23565	14	23	society	society	NOUN
bjp-23565	14	24	(	(	PUNCT
bjp-23565	14	25	bdps	bdps	NOUN
bjp-23565	14	26	)	)	PUNCT
bjp-23565	14	27	bangladesh	bangladesh	PROPN
bjp-23565	14	28	j	j	PROPN
bjp-23565	14	29	pharmacol	pharmacol	PROPN
bjp-23565	14	30	2015	2015	NUM
bjp-23565	14	31	;	;	PUNCT
bjp-23565	14	32	10	10	NUM
bjp-23565	14	33	:	:	PUNCT
bjp-23565	14	34	799	799	NUM
bjp-23565	14	35	-	-	SYM
bjp-23565	14	36	806	806	NUM
bjp-23565	14	37	abstract	abstract	ADJ
bjp-23565	14	38	breast	breast	NOUN
bjp-23565	14	39	cancer	cancer	NOUN
bjp-23565	14	40	is	be	AUX
bjp-23565	14	41	the	the	DET
bjp-23565	14	42	most	most	ADV
bjp-23565	14	43	common	common	ADJ
bjp-23565	14	44	type	type	NOUN
bjp-23565	14	45	of	of	ADP
bjp-23565	14	46	cancers	cancer	NOUN
bjp-23565	14	47	and	and	CCONJ
bjp-23565	14	48	second	second	ADJ
bjp-23565	14	49	primary	primary	ADJ
bjp-23565	14	50	cause	cause	NOUN
bjp-23565	14	51	of	of	ADP
bjp-23565	14	52	death	death	NOUN
bjp-23565	14	53	among	among	ADP
bjp-23565	14	54	women	woman	NOUN
bjp-23565	14	55	.	.	PUNCT
bjp-23565	15	1	insulin	insulin	NOUN
bjp-23565	15	2	-	-	PUNCT
bjp-23565	15	3	like	like	ADJ
bjp-23565	15	4	growth	growth	NOUN
bjp-23565	15	5	factor	factor	NOUN
bjp-23565	15	6	i	i	PRON
bjp-23565	15	7	(	(	PUNCT
bjp-23565	15	8	igf-1	igf-1	NOUN
bjp-23565	15	9	)	)	PUNCT
bjp-23565	15	10	signaling	signal	VERB
bjp-23565	15	11	pathway	pathway	NOUN
bjp-23565	15	12	plays	play	VERB
bjp-23565	15	13	a	a	DET
bjp-23565	15	14	vital	vital	ADJ
bjp-23565	15	15	role	role	NOUN
bjp-23565	15	16	in	in	ADP
bjp-23565	15	17	cancer	cancer	NOUN
bjp-23565	15	18	cell	cell	NOUN
bjp-23565	15	19	survival	survival	NOUN
bjp-23565	15	20	,	,	PUNCT
bjp-23565	15	21	proliferation	proliferation	NOUN
bjp-23565	15	22	,	,	PUNCT
bjp-23565	15	23	chemotaxis	chemotaxis	ADJ
bjp-23565	15	24	and	and	CCONJ
bjp-23565	15	25	angiogenesis	angiogenesis	NOUN
bjp-23565	15	26	.	.	PUNCT
bjp-23565	16	1	in	in	ADP
bjp-23565	16	2	this	this	DET
bjp-23565	16	3	study	study	NOUN
bjp-23565	16	4	,	,	PUNCT
bjp-23565	16	5	the	the	DET
bjp-23565	16	6	effect	effect	NOUN
bjp-23565	16	7	of	of	ADP
bjp-23565	16	8	combination	combination	NOUN
bjp-23565	16	9	of	of	ADP
bjp-23565	16	10	two	two	NUM
bjp-23565	16	11	drugs	drug	NOUN
bjp-23565	16	12	,	,	PUNCT
bjp-23565	16	13	paclitaxel	paclitaxel	NOUN
bjp-23565	16	14	and	and	CCONJ
bjp-23565	16	15	trastuzumab	trastuzumab	NOUN
bjp-23565	16	16	on	on	ADP
bjp-23565	16	17	igf	igf	PROPN
bjp-23565	16	18	signaling	signal	VERB
bjp-23565	16	19	and	and	CCONJ
bjp-23565	16	20	cell	cell	NOUN
bjp-23565	16	21	cycle	cycle	NOUN
bjp-23565	16	22	arrest	arrest	NOUN
bjp-23565	16	23	in	in	ADP
bjp-23565	16	24	breast	breast	NOUN
bjp-23565	16	25	cancer	cancer	NOUN
bjp-23565	16	26	cell	cell	NOUN
bjp-23565	16	27	lines	line	NOUN
bjp-23565	16	28	,	,	PUNCT
bjp-23565	16	29	t47d	t47d	PRON
bjp-23565	16	30	and	and	CCONJ
bjp-23565	16	31	hs0578	hs0578	PROPN
bjp-23565	16	32	t	t	PROPN
bjp-23565	16	33	were	be	AUX
bjp-23565	16	34	explored	explore	VERB
bjp-23565	16	35	.	.	PUNCT
bjp-23565	17	1	the	the	DET
bjp-23565	17	2	interaction	interaction	NOUN
bjp-23565	17	3	of	of	ADP
bjp-23565	17	4	paclitaxel	paclitaxel	NOUN
bjp-23565	17	5	and	and	CCONJ
bjp-23565	17	6	trastuzumab	trastuzumab	NOUN
bjp-23565	17	7	on	on	ADP
bjp-23565	17	8	igf-1	igf-1	NOUN
bjp-23565	17	9	signaling	signal	VERB
bjp-23565	17	10	pathway	pathway	NOUN
bjp-23565	17	11	was	be	AUX
bjp-23565	17	12	studied	study	VERB
bjp-23565	17	13	with	with	ADP
bjp-23565	17	14	igf-1	igf-1	NOUN
bjp-23565	17	15	and	and	CCONJ
bjp-23565	17	16	phosphoinositide	phosphoinositide	ADJ
bjp-23565	17	17	3	3	NUM
bjp-23565	17	18	-	-	PUNCT
bjp-23565	17	19	kinase	kinase	NOUN
bjp-23565	17	20	inhibitor	inhibitor	NOUN
bjp-23565	17	21	,	,	PUNCT
bjp-23565	17	22	ly294002	ly294002	PROPN
bjp-23565	17	23	.	.	PUNCT
bjp-23565	18	1	the	the	DET
bjp-23565	18	2	protein	protein	NOUN
bjp-23565	18	3	expression	expression	NOUN
bjp-23565	18	4	of	of	ADP
bjp-23565	18	5	igf	igf	PROPN
bjp-23565	18	6	signaling	signal	VERB
bjp-23565	18	7	molecules	molecule	NOUN
bjp-23565	18	8	were	be	AUX
bjp-23565	18	9	reduced	reduce	VERB
bjp-23565	18	10	in	in	ADP
bjp-23565	18	11	the	the	DET
bjp-23565	18	12	drug	drug	NOUN
bjp-23565	18	13	treated	treat	VERB
bjp-23565	18	14	cancer	cancer	NOUN
bjp-23565	18	15	cells	cell	NOUN
bjp-23565	18	16	.	.	PUNCT
bjp-23565	19	1	ly294002	ly294002	NOUN
bjp-23565	19	2	and	and	CCONJ
bjp-23565	19	3	igf-1	igf-1	ADV
bjp-23565	19	4	with	with	ADP
bjp-23565	19	5	paclitaxel	paclitaxel	NOUN
bjp-23565	19	6	and	and	CCONJ
bjp-23565	19	7	trastuzumab	trastuzumab	NOUN
bjp-23565	19	8	treatment	treatment	NOUN
bjp-23565	19	9	inhibited	inhibit	VERB
bjp-23565	19	10	phosphorylated	phosphorylate	VERB
bjp-23565	19	11	akt	akt	NOUN
bjp-23565	19	12	.	.	PUNCT
bjp-23565	20	1	during	during	ADP
bjp-23565	20	2	g0	g0	PROPN
bjp-23565	20	3	/	/	SYM
bjp-23565	20	4	g1	g1	PROPN
bjp-23565	20	5	phase	phase	NOUN
bjp-23565	20	6	,	,	PUNCT
bjp-23565	20	7	cell	cell	NOUN
bjp-23565	20	8	cycle	cycle	NOUN
bjp-23565	20	9	arrest	arrest	NOUN
bjp-23565	20	10	and	and	CCONJ
bjp-23565	20	11	accumulation	accumulation	NOUN
bjp-23565	20	12	of	of	ADP
bjp-23565	20	13	apoptotic	apoptotic	ADJ
bjp-23565	20	14	cells	cell	NOUN
bjp-23565	20	15	were	be	AUX
bjp-23565	20	16	observed	observe	VERB
bjp-23565	20	17	in	in	ADP
bjp-23565	20	18	drug	drug	NOUN
bjp-23565	20	19	treated	treat	VERB
bjp-23565	20	20	cancer	cancer	NOUN
bjp-23565	20	21	cells	cell	NOUN
bjp-23565	20	22	.	.	PUNCT
bjp-23565	21	1	the	the	DET
bjp-23565	21	2	synergistic	synergistic	ADJ
bjp-23565	21	3	effect	effect	NOUN
bjp-23565	21	4	of	of	ADP
bjp-23565	21	5	paclitaxel	paclitaxel	PROPN
bjp-23565	21	6	and	and	CCONJ
bjp-23565	21	7	trastuzumab	trastuzumab	NOUN
bjp-23565	21	8	decreased	decrease	VERB
bjp-23565	21	9	the	the	DET
bjp-23565	21	10	multiplication	multiplication	NOUN
bjp-23565	21	11	of	of	ADP
bjp-23565	21	12	breast	breast	NOUN
bjp-23565	21	13	cancer	cancer	NOUN
bjp-23565	21	14	cells	cell	NOUN
bjp-23565	21	15	by	by	ADP
bjp-23565	21	16	altering	alter	VERB
bjp-23565	21	17	the	the	DET
bjp-23565	21	18	expression	expression	NOUN
bjp-23565	21	19	of	of	ADP
bjp-23565	21	20	igf	igf	PROPN
bjp-23565	21	21	-	-	PROPN
bjp-23565	21	22	i	i	PRON
bjp-23565	21	23	signaling	signal	VERB
bjp-23565	21	24	molecules	molecule	NOUN
bjp-23565	21	25	.	.	PUNCT
bjp-23565	22	1	this	this	DET
bjp-23565	22	2	combination	combination	NOUN
bjp-23565	22	3	proves	prove	VERB
bjp-23565	22	4	to	to	PART
bjp-23565	22	5	be	be	AUX
bjp-23565	22	6	one	one	NUM
bjp-23565	22	7	of	of	ADP
bjp-23565	22	8	the	the	DET
bjp-23565	22	9	useful	useful	ADJ
bjp-23565	22	10	methods	method	NOUN
bjp-23565	22	11	to	to	PART
bjp-23565	22	12	treat	treat	VERB
bjp-23565	22	13	breast	breast	NOUN
bjp-23565	22	14	cancer	cancer	NOUN
bjp-23565	22	15	.	.	PUNCT
bjp-23565	23	1	article	article	NOUN
bjp-23565	23	2	info	info	NOUN
bjp-23565	23	3	received	receive	VERB
bjp-23565	23	4	:	:	PUNCT
bjp-23565	23	5	2	2	NUM
bjp-23565	23	6	june	june	PROPN
bjp-23565	23	7	2015	2015	NUM
bjp-23565	23	8	accepted	accept	VERB
bjp-23565	23	9	:	:	PUNCT
bjp-23565	23	10	25	25	NUM
bjp-23565	23	11	june	june	PROPN
bjp-23565	23	12	2015	2015	NUM
bjp-23565	23	13	available	available	ADJ
bjp-23565	23	14	online	online	ADV
bjp-23565	23	15	:	:	PUNCT
bjp-23565	23	16	30	30	NUM
bjp-23565	23	17	september	september	PROPN
bjp-23565	23	18	2015	2015	NUM
bjp-23565	23	19	doi	doi	NOUN
bjp-23565	23	20	:	:	PUNCT
bjp-23565	23	21	10.3329	10.3329	NUM
bjp-23565	23	22	/	/	SYM
bjp-23565	23	23	bjp.v10i4.23565	bjp.v10i4.23565	PROPN
bjp-23565	23	24	cite	cite	VERB
bjp-23565	23	25	this	this	DET
bjp-23565	23	26	article	article	NOUN
bjp-23565	23	27	:	:	PUNCT
bjp-23565	23	28	qian	qian	PROPN
bjp-23565	23	29	yx	yx	PROPN
bjp-23565	23	30	,	,	PUNCT
bjp-23565	23	31	yu	yu	PROPN
bjp-23565	23	32	r	r	PROPN
bjp-23565	23	33	,	,	PUNCT
bjp-23565	23	34	qin	qin	PROPN
bjp-23565	23	35	sr	sr	PROPN
bjp-23565	23	36	.	.	PUNCT
bjp-23565	24	1	paclitaxel	paclitaxel	PROPN
bjp-23565	24	2	and	and	CCONJ
bjp-23565	24	3	trastuzumab	trastuzumab	NOUN
bjp-23565	24	4	treatment	treatment	NOUN
bjp-23565	24	5	affects	affect	VERB
bjp-23565	24	6	insulin	insulin	NOUN
bjp-23565	24	7	growth	growth	NOUN
bjp-23565	24	8	factor	factor	NOUN
bjp-23565	24	9	i	i	PRON
bjp-23565	24	10	expression	expression	NOUN
bjp-23565	24	11	in	in	ADP
bjp-23565	24	12	breast	breast	NOUN
bjp-23565	24	13	cancer	cancer	NOUN
bjp-23565	24	14	cell	cell	NOUN
bjp-23565	24	15	lines	line	NOUN
bjp-23565	24	16	.	.	PUNCT
bjp-23565	25	1	bangladesh	bangladesh	PROPN
bjp-23565	25	2	j	j	PROPN
bjp-23565	25	3	pharmacol	pharmacol	PROPN
bjp-23565	25	4	.	.	PROPN
bjp-23565	26	1	2015	2015	NUM
bjp-23565	26	2	;	;	PUNCT
bjp-23565	27	1	10	10	NUM
bjp-23565	27	2	:	:	PUNCT
bjp-23565	27	3	799	799	NUM
bjp-23565	27	4	-	-	SYM
bjp-23565	27	5	806	806	NUM
bjp-23565	27	6	.	.	PUNCT
bjp-23565	28	1	journal	journal	PROPN
bjp-23565	28	2	homepage	homepage	NOUN
bjp-23565	28	3	:	:	PUNCT
bjp-23565	28	4	www.banglajol.info	www.banglajol.info	PROPN
bjp-23565	28	5	abstracted	abstract	VERB
bjp-23565	28	6	/	/	SYM
bjp-23565	28	7	indexed	index	VERB
bjp-23565	28	8	in	in	ADP
bjp-23565	28	9	academic	academic	ADJ
bjp-23565	28	10	search	search	NOUN
bjp-23565	28	11	complete	complete	ADJ
bjp-23565	28	12	,	,	PUNCT
bjp-23565	28	13	agroforestry	agroforestry	NOUN
bjp-23565	28	14	abstracts	abstract	NOUN
bjp-23565	28	15	,	,	PUNCT
bjp-23565	28	16	asia	asia	PROPN
bjp-23565	28	17	journals	journal	NOUN
bjp-23565	28	18	online	online	ADV
bjp-23565	28	19	,	,	PUNCT
bjp-23565	28	20	bangladesh	bangladesh	NOUN
bjp-23565	28	21	journals	journal	NOUN
bjp-23565	28	22	online	online	ADV
bjp-23565	28	23	,	,	PUNCT
bjp-23565	28	24	biological	biological	ADJ
bjp-23565	28	25	abstracts	abstract	NOUN
bjp-23565	28	26	,	,	PUNCT
bjp-23565	28	27	biosis	biosis	NOUN
bjp-23565	28	28	previews	preview	NOUN
bjp-23565	28	29	,	,	PUNCT
bjp-23565	28	30	cab	cab	NOUN
bjp-23565	28	31	abstracts	abstract	NOUN
bjp-23565	28	32	,	,	PUNCT
bjp-23565	28	33	current	current	ADJ
bjp-23565	28	34	abstracts	abstract	NOUN
bjp-23565	28	35	,	,	PUNCT
bjp-23565	28	36	directory	directory	NOUN
bjp-23565	28	37	of	of	ADP
bjp-23565	28	38	open	open	ADJ
bjp-23565	28	39	access	access	NOUN
bjp-23565	28	40	journals	journal	NOUN
bjp-23565	28	41	,	,	PUNCT
bjp-23565	28	42	embase	embase	NOUN
bjp-23565	28	43	/	/	SYM
bjp-23565	28	44	excerpta	excerpta	NOUN
bjp-23565	28	45	medica	medica	NOUN
bjp-23565	28	46	,	,	PUNCT
bjp-23565	28	47	google	google	PROPN
bjp-23565	28	48	scholar	scholar	NOUN
bjp-23565	28	49	,	,	PUNCT
bjp-23565	28	50	hinari	hinari	X
bjp-23565	28	51	(	(	PUNCT
bjp-23565	28	52	who	who	PRON
bjp-23565	28	53	)	)	PUNCT
bjp-23565	28	54	,	,	PUNCT
bjp-23565	28	55	international	international	ADJ
bjp-23565	28	56	pharmaceutical	pharmaceutical	ADJ
bjp-23565	28	57	abstracts	abstract	NOUN
bjp-23565	28	58	,	,	PUNCT
bjp-23565	28	59	open	open	ADJ
bjp-23565	28	60	j	j	PROPN
bjp-23565	28	61	-	-	PUNCT
bjp-23565	28	62	gate	gate	NOUN
bjp-23565	28	63	,	,	PUNCT
bjp-23565	28	64	science	science	NOUN
bjp-23565	28	65	citation	citation	NOUN
bjp-23565	28	66	index	index	NOUN
bjp-23565	28	67	expanded	expand	VERB
bjp-23565	28	68	,	,	PUNCT
bjp-23565	28	69	scopus	scopus	NOUN
bjp-23565	28	70	and	and	CCONJ
bjp-23565	28	71	social	social	ADJ
bjp-23565	28	72	sciences	sciences	PROPN
bjp-23565	28	73	citation	citation	NOUN
bjp-23565	28	74	index	index	NOUN
bjp-23565	28	75	;	;	PUNCT
bjp-23565	28	76	issn	issn	PROPN
bjp-23565	28	77	:	:	PUNCT
bjp-23565	28	78	1991	1991	NUM
bjp-23565	28	79	-	-	SYM
bjp-23565	28	80	0088	0088	NUM
bjp-23565	28	81	paclitaxel	paclitaxel	NOUN
bjp-23565	28	82	and	and	CCONJ
bjp-23565	28	83	trastuzumab	trastuzumab	NOUN
bjp-23565	28	84	treatment	treatment	NOUN
bjp-23565	28	85	affects	affect	VERB
bjp-23565	28	86	insulin	insulin	NOUN
bjp-23565	28	87	growth	growth	NOUN
bjp-23565	28	88	factor	factor	NOUN
bjp-23565	28	89	i	i	PRON
bjp-23565	28	90	expression	expression	NOUN
bjp-23565	28	91	in	in	ADP
bjp-23565	28	92	breast	breast	NOUN
bjp-23565	28	93	cancer	cancer	NOUN
bjp-23565	28	94	cell	cell	NOUN
bjp-23565	28	95	lines	line	NOUN
bjp-23565	28	96	yu	yu	PROPN
bjp-23565	28	97	-	-	PROPN
bjp-23565	28	98	xian	xian	PROPN
bjp-23565	28	99	qian1	qian1	PROPN
bjp-23565	28	100	,	,	PUNCT
bjp-23565	28	101	rui	rui	PROPN
bjp-23565	28	102	yu2	yu2	PROPN
bjp-23565	28	103	and	and	CCONJ
bjp-23565	28	104	shi	shi	PROPN
bjp-23565	28	105	-	-	PUNCT
bjp-23565	28	106	rong	rong	PROPN
bjp-23565	28	107	qin1	qin1	PROPN
bjp-23565	28	108	1department	1department	NUM
bjp-23565	28	109	of	of	ADP
bjp-23565	28	110	general	general	ADJ
bjp-23565	28	111	surgery	surgery	NOUN
bjp-23565	28	112	,	,	PUNCT
bjp-23565	28	113	ningbo	ningbo	PROPN
bjp-23565	28	114	longsai	longsai	PROPN
bjp-23565	28	115	hospital	hospital	PROPN
bjp-23565	28	116	,	,	PUNCT
bjp-23565	28	117	zhejiang	zhejiang	PROPN
bjp-23565	28	118	province	province	PROPN
bjp-23565	28	119	,	,	PUNCT
bjp-23565	28	120	315	315	NUM
bjp-23565	28	121	200	200	NUM
bjp-23565	28	122	,	,	PUNCT
bjp-23565	28	123	china	china	PROPN
bjp-23565	28	124	;	;	PUNCT
bjp-23565	28	125	2medical	2medical	NUM
bjp-23565	28	126	school	school	NOUN
bjp-23565	28	127	,	,	PUNCT
bjp-23565	28	128	ningbo	ningbo	PROPN
bjp-23565	28	129	university	university	PROPN
bjp-23565	28	130	,	,	PUNCT
bjp-23565	28	131	ningbo	ningbo	PROPN
bjp-23565	28	132	city	city	PROPN
bjp-23565	28	133	,	,	PUNCT
bjp-23565	28	134	zhejiang	zhejiang	PROPN
bjp-23565	28	135	province	province	PROPN
bjp-23565	28	136	,	,	PUNCT
bjp-23565	28	137	315	315	NUM
bjp-23565	28	138	211	211	NUM
bjp-23565	28	139	,	,	PUNCT
bjp-23565	28	140	china	china	PROPN
bjp-23565	28	141	.	.	PUNCT
bjp-23565	29	1	this	this	DET
bjp-23565	29	2	work	work	NOUN
bjp-23565	29	3	is	be	AUX
bjp-23565	29	4	licensed	license	VERB
bjp-23565	29	5	under	under	ADP
bjp-23565	29	6	a	a	DET
bjp-23565	29	7	creative	creative	ADJ
bjp-23565	29	8	commons	common	NOUN
bjp-23565	29	9	attribution	attribution	NOUN
bjp-23565	29	10	4.0	4.0	NUM
bjp-23565	29	11	license	license	NOUN
bjp-23565	29	12	.	.	PUNCT
bjp-23565	30	1	you	you	PRON
bjp-23565	30	2	are	be	AUX
bjp-23565	30	3	free	free	ADJ
bjp-23565	30	4	to	to	PART
bjp-23565	30	5	copy	copy	VERB
bjp-23565	30	6	,	,	PUNCT
bjp-23565	30	7	distribute	distribute	VERB
bjp-23565	30	8	and	and	CCONJ
bjp-23565	30	9	perform	perform	VERB
bjp-23565	30	10	the	the	DET
bjp-23565	30	11	work	work	NOUN
bjp-23565	30	12	.	.	PUNCT
bjp-23565	31	1	you	you	PRON
bjp-23565	31	2	must	must	AUX
bjp-23565	31	3	attribute	attribute	VERB
bjp-23565	31	4	the	the	DET
bjp-23565	31	5	work	work	NOUN
bjp-23565	31	6	in	in	ADP
bjp-23565	31	7	the	the	DET
bjp-23565	31	8	manner	manner	NOUN
bjp-23565	31	9	specified	specify	VERB
bjp-23565	31	10	by	by	ADP
bjp-23565	31	11	the	the	DET
bjp-23565	31	12	author	author	NOUN
bjp-23565	31	13	or	or	CCONJ
bjp-23565	31	14	licensor	licensor	NOUN
bjp-23565	31	15	.	.	PUNCT
bjp-23565	32	1	cancers	cancer	NOUN
bjp-23565	32	2	such	such	ADJ
bjp-23565	32	3	as	as	ADP
bjp-23565	32	4	ovarian	ovarian	ADJ
bjp-23565	32	5	cancer	cancer	NOUN
bjp-23565	32	6	,	,	PUNCT
bjp-23565	32	7	breast	breast	NOUN
bjp-23565	32	8	cancer	cancer	NOUN
bjp-23565	32	9	,	,	PUNCT
bjp-23565	32	10	pancreatic	pancreatic	ADJ
bjp-23565	32	11	cancer	cancer	NOUN
bjp-23565	32	12	and	and	CCONJ
bjp-23565	32	13	lung	lung	NOUN
bjp-23565	32	14	cancer	cancer	NOUN
bjp-23565	32	15	(	(	PUNCT
bjp-23565	32	16	manfredi	manfredi	PROPN
bjp-23565	32	17	and	and	CCONJ
bjp-23565	32	18	horwitz	horwitz	PROPN
bjp-23565	32	19	,	,	PUNCT
bjp-23565	32	20	1984	1984	NUM
bjp-23565	32	21	)	)	PUNCT
bjp-23565	32	22	.	.	PUNCT
bjp-23565	33	1	studies	study	NOUN
bjp-23565	33	2	have	have	AUX
bjp-23565	33	3	shown	show	VERB
bjp-23565	33	4	that	that	SCONJ
bjp-23565	33	5	patients	patient	NOUN
bjp-23565	33	6	treated	treat	VERB
bjp-23565	33	7	with	with	ADP
bjp-23565	33	8	paclitaxel	paclitaxel	PROPN
bjp-23565	33	9	for	for	ADP
bjp-23565	33	10	ovarian	ovarian	ADJ
bjp-23565	33	11	and	and	CCONJ
bjp-23565	33	12	breast	breast	NOUN
bjp-23565	33	13	cancer	cancer	NOUN
bjp-23565	33	14	showed	show	VERB
bjp-23565	33	15	promising	promising	ADJ
bjp-23565	33	16	results	result	NOUN
bjp-23565	33	17	(	(	PUNCT
bjp-23565	33	18	mcguire	mcguire	PROPN
bjp-23565	33	19	et	et	PROPN
bjp-23565	33	20	al	al	PROPN
bjp-23565	33	21	.	.	PROPN
bjp-23565	33	22	,	,	PUNCT
bjp-23565	33	23	1989	1989	NUM
bjp-23565	33	24	;	;	PUNCT
bjp-23565	33	25	holmes	holmes	PROPN
bjp-23565	33	26	et	et	PROPN
bjp-23565	33	27	al	al	PROPN
bjp-23565	33	28	.	.	PROPN
bjp-23565	33	29	,	,	PUNCT
bjp-23565	33	30	1991	1991	NUM
bjp-23565	33	31	)	)	PUNCT
bjp-23565	33	32	.	.	PUNCT
bjp-23565	34	1	most	most	ADJ
bjp-23565	34	2	of	of	ADP
bjp-23565	34	3	the	the	DET
bjp-23565	34	4	studies	study	NOUN
bjp-23565	34	5	done	do	VERB
bjp-23565	34	6	before	before	ADP
bjp-23565	34	7	the	the	DET
bjp-23565	34	8	clinical	clinical	ADJ
bjp-23565	34	9	trials	trial	NOUN
bjp-23565	34	10	were	be	AUX
bjp-23565	34	11	based	base	VERB
bjp-23565	34	12	on	on	ADP
bjp-23565	34	13	growth	growth	NOUN
bjp-23565	34	14	inhibition	inhibition	NOUN
bjp-23565	34	15	assays	assay	NOUN
bjp-23565	34	16	(	(	PUNCT
bjp-23565	34	17	rowinsky	rowinsky	NOUN
bjp-23565	34	18	et	et	PROPN
bjp-23565	34	19	al	al	PROPN
bjp-23565	34	20	.	.	PROPN
bjp-23565	34	21	,	,	PUNCT
bjp-23565	34	22	1990	1990	NUM
bjp-23565	34	23	)	)	PUNCT
bjp-23565	34	24	.	.	PUNCT
bjp-23565	35	1	the	the	DET
bjp-23565	35	2	effectiveness	effectiveness	NOUN
bjp-23565	35	3	of	of	ADP
bjp-23565	35	4	drugs	drug	NOUN
bjp-23565	35	5	like	like	ADP
bjp-23565	35	6	trastuzumab	trastuzumab	NOUN
bjp-23565	35	7	,	,	PUNCT
bjp-23565	35	8	a	a	DET
bjp-23565	35	9	monoclonal	monoclonal	NOUN
bjp-23565	35	10	antibody	antibody	NOUN
bjp-23565	35	11	used	use	VERB
bjp-23565	35	12	for	for	ADP
bjp-23565	35	13	treating	treat	VERB
bjp-23565	35	14	breast	breast	NOUN
bjp-23565	35	15	cancer	cancer	NOUN
bjp-23565	35	16	showed	show	VERB
bjp-23565	35	17	that	that	SCONJ
bjp-23565	35	18	targeting	target	VERB
bjp-23565	35	19	the	the	DET
bjp-23565	35	20	receptors	receptor	NOUN
bjp-23565	35	21	of	of	ADP
bjp-23565	35	22	growth	growth	NOUN
bjp-23565	35	23	factors	factor	NOUN
bjp-23565	35	24	will	will	AUX
bjp-23565	35	25	be	be	AUX
bjp-23565	35	26	useful	useful	ADJ
bjp-23565	35	27	(	(	PUNCT
bjp-23565	35	28	slamon	slamon	NOUN
bjp-23565	35	29	et	et	PROPN
bjp-23565	35	30	al	al	PROPN
bjp-23565	35	31	.	.	PROPN
bjp-23565	35	32	,	,	PUNCT
bjp-23565	35	33	2001	2001	NUM
bjp-23565	35	34	;	;	PUNCT
bjp-23565	35	35	romond	romond	PROPN
bjp-23565	35	36	et	et	PROPN
bjp-23565	35	37	al	al	PROPN
bjp-23565	35	38	.	.	PROPN
bjp-23565	35	39	,	,	PUNCT
bjp-23565	35	40	2005	2005	NUM
bjp-23565	35	41	;	;	PUNCT
bjp-23565	35	42	piccartgebhart	piccartgebhart	NOUN
bjp-23565	35	43	et	et	PROPN
bjp-23565	35	44	al	al	PROPN
bjp-23565	35	45	.	.	PROPN
bjp-23565	35	46	,	,	PUNCT
bjp-23565	35	47	2005	2005	NUM
bjp-23565	35	48	)	)	PUNCT
bjp-23565	35	49	.	.	PUNCT
bjp-23565	36	1	the	the	DET
bjp-23565	36	2	action	action	NOUN
bjp-23565	36	3	of	of	ADP
bjp-23565	36	4	combination	combination	NOUN
bjp-23565	36	5	therapy	therapy	NOUN
bjp-23565	36	6	of	of	ADP
bjp-23565	36	7	paclitaxel	paclitaxel	PROPN
bjp-23565	36	8	and	and	CCONJ
bjp-23565	36	9	trastuzumab	trastuzumab	NOUN
bjp-23565	36	10	in	in	ADP
bjp-23565	36	11	breast	breast	NOUN
bjp-23565	36	12	cancer	cancer	NOUN
bjp-23565	36	13	cell	cell	NOUN
bjp-23565	36	14	growth	growth	NOUN
bjp-23565	36	15	and	and	CCONJ
bjp-23565	36	16	division	division	NOUN
bjp-23565	36	17	have	have	AUX
bjp-23565	36	18	not	not	PART
bjp-23565	36	19	been	be	AUX
bjp-23565	36	20	studied	study	VERB
bjp-23565	36	21	.	.	PUNCT
bjp-23565	37	1	in	in	ADP
bjp-23565	37	2	this	this	DET
bjp-23565	37	3	study	study	NOUN
bjp-23565	37	4	,	,	PUNCT
bjp-23565	37	5	we	we	PRON
bjp-23565	37	6	investigated	investigate	VERB
bjp-23565	37	7	the	the	DET
bjp-23565	37	8	cell	cell	NOUN
bjp-23565	37	9	cycle	cycle	NOUN
bjp-23565	37	10	arrest	arrest	NOUN
bjp-23565	37	11	and	and	CCONJ
bjp-23565	37	12	inhibition	inhibition	NOUN
bjp-23565	37	13	of	of	ADP
bjp-23565	37	14	cell	cell	NOUN
bjp-23565	37	15	proliferation	proliferation	NOUN
bjp-23565	37	16	by	by	ADP
bjp-23565	37	17	drug	drug	NOUN
bjp-23565	37	18	treatment	treatment	NOUN
bjp-23565	37	19	was	be	AUX
bjp-23565	37	20	studied	study	VERB
bjp-23565	37	21	on	on	ADP
bjp-23565	37	22	estrogen	estrogen	NOUN
bjp-23565	37	23	receptor	receptor	NOUN
bjp-23565	37	24	alpha	alpha	NOUN
bjp-23565	37	25	positive	positive	ADJ
bjp-23565	37	26	(	(	PUNCT
bjp-23565	37	27	er+	er+	NOUN
bjp-23565	37	28	)	)	PUNCT
bjp-23565	37	29	human	human	ADJ
bjp-23565	37	30	breast	breast	NOUN
bjp-23565	37	31	cancer	cancer	NOUN
bjp-23565	37	32	line	line	NOUN
bjp-23565	37	33	,	,	PUNCT
bjp-23565	37	34	t47d	t47d	PRON
bjp-23565	37	35	and	and	CCONJ
bjp-23565	37	36	erhuman	erhuman	PROPN
bjp-23565	37	37	breast	breast	NOUN
bjp-23565	37	38	cancer	cancer	NOUN
bjp-23565	37	39	cell	cell	NOUN
bjp-23565	37	40	line	line	NOUN
bjp-23565	37	41	,	,	PUNCT
bjp-23565	37	42	hs0578	hs0578	NOUN
bjp-23565	37	43	t.	t.	NOUN
bjp-23565	37	44	materials	material	NOUN
bjp-23565	37	45	and	and	CCONJ
bjp-23565	37	46	methods	method	NOUN
bjp-23565	37	47	materials	material	NOUN
bjp-23565	37	48	all	all	DET
bjp-23565	37	49	the	the	DET
bjp-23565	37	50	chemicals	chemical	NOUN
bjp-23565	37	51	and	and	CCONJ
bjp-23565	37	52	reagents	reagent	NOUN
bjp-23565	37	53	used	use	VERB
bjp-23565	37	54	in	in	ADP
bjp-23565	37	55	this	this	DET
bjp-23565	37	56	study	study	NOUN
bjp-23565	37	57	were	be	AUX
bjp-23565	37	58	of	of	ADP
bjp-23565	37	59	pure	pure	ADJ
bjp-23565	37	60	and	and	CCONJ
bjp-23565	37	61	analytical	analytical	ADJ
bjp-23565	37	62	grade	grade	NOUN
bjp-23565	37	63	.	.	PUNCT
bjp-23565	38	1	paclitaxel	paclitaxel	PROPN
bjp-23565	38	2	(	(	PUNCT
bjp-23565	38	3	tradename	tradename	PROPN
bjp-23565	38	4	:	:	PUNCT
bjp-23565	38	5	taxol	taxol	PROPN
bjp-23565	38	6	)	)	PUNCT
bjp-23565	38	7	and	and	CCONJ
bjp-23565	38	8	trastuzumab	trastuzumab	NOUN
bjp-23565	38	9	(	(	PUNCT
bjp-23565	38	10	tradename	tradename	NOUN
bjp-23565	38	11	:	:	PUNCT
bjp-23565	38	12	herceptin	herceptin	PROPN
bjp-23565	38	13	)	)	PUNCT
bjp-23565	38	14	were	be	AUX
bjp-23565	38	15	purchase	purchase	NOUN
bjp-23565	38	16	from	from	ADP
bjp-23565	38	17	bristol	bristol	PROPN
bjp-23565	38	18	myers	myers	PROPN
bjp-23565	38	19	-	-	PUNCT
bjp-23565	38	20	squibb	squibb	PROPN
bjp-23565	38	21	company	company	PROPN
bjp-23565	38	22	(	(	PUNCT
bjp-23565	38	23	usa	usa	PROPN
bjp-23565	38	24	)	)	PUNCT
bjp-23565	38	25	and	and	CCONJ
bjp-23565	38	26	roche	roche	PROPN
bjp-23565	38	27	(	(	PUNCT
bjp-23565	38	28	switzerland	switzerland	PROPN
bjp-23565	38	29	)	)	PUNCT
bjp-23565	38	30	respectively	respectively	ADV
bjp-23565	38	31	.	.	PUNCT
bjp-23565	39	1	dmem	dmem	VERB
bjp-23565	39	2	medium	medium	ADJ
bjp-23565	39	3	,	,	PUNCT
bjp-23565	39	4	fbs	fbs	ADJ
bjp-23565	39	5	,	,	PUNCT
bjp-23565	39	6	trypsin	trypsin	NOUN
bjp-23565	39	7	-	-	PUNCT
bjp-23565	39	8	edta	edta	NOUN
bjp-23565	39	9	,	,	PUNCT
bjp-23565	39	10	pvdf	pvdf	PROPN
bjp-23565	39	11	membrane	membrane	NOUN
bjp-23565	39	12	,	,	PUNCT
bjp-23565	39	13	antibiotics	antibiotic	NOUN
bjp-23565	39	14	-	-	PUNCT
bjp-23565	39	15	antimycotics	antimycotic	NOUN
bjp-23565	39	16	and	and	CCONJ
bjp-23565	39	17	pbs	pbs	PROPN
bjp-23565	39	18	were	be	AUX
bjp-23565	39	19	acquired	acquire	VERB
bjp-23565	39	20	form	form	NOUN
bjp-23565	39	21	life	life	NOUN
bjp-23565	39	22	technologies	technology	NOUN
bjp-23565	39	23	(	(	PUNCT
bjp-23565	39	24	usa	usa	PROPN
bjp-23565	39	25	)	)	PUNCT
bjp-23565	39	26	.	.	PUNCT
bjp-23565	40	1	human	human	ADJ
bjp-23565	40	2	igf-1	igf-1	NOUN
bjp-23565	40	3	,	,	PUNCT
bjp-23565	40	4	hrp	hrp	NOUN
bjp-23565	40	5	-	-	PUNCT
bjp-23565	40	6	conjugated	conjugate	VERB
bjp-23565	40	7	rabbit	rabbit	NOUN
bjp-23565	40	8	anti	anti	ADJ
bjp-23565	40	9	-	-	ADJ
bjp-23565	40	10	mouse	mouse	ADJ
bjp-23565	40	11	igg	igg	PROPN
bjp-23565	40	12	and	and	CCONJ
bjp-23565	40	13	goat	goat	PROPN
bjp-23565	40	14	anti	anti	ADJ
bjp-23565	40	15	-	-	ADJ
bjp-23565	40	16	rabbit	rabbit	ADJ
bjp-23565	40	17	igg	igg	PROPN
bjp-23565	40	18	secondary	secondary	ADJ
bjp-23565	40	19	antibodies	antibody	NOUN
bjp-23565	40	20	were	be	AUX
bjp-23565	40	21	purchased	purchase	VERB
bjp-23565	40	22	from	from	ADP
bjp-23565	40	23	sigmaaldrich	sigmaaldrich	PROPN
bjp-23565	40	24	(	(	PUNCT
bjp-23565	40	25	usa	usa	PROPN
bjp-23565	40	26	)	)	PUNCT
bjp-23565	40	27	.	.	PUNCT
bjp-23565	41	1	primary	primary	ADJ
bjp-23565	41	2	antibodies	antibody	NOUN
bjp-23565	41	3	for	for	ADP
bjp-23565	41	4	igf	igf	PROPN
bjp-23565	41	5	signaling	signal	VERB
bjp-23565	41	6	molecules	molecule	NOUN
bjp-23565	41	7	,	,	PUNCT
bjp-23565	41	8	proliferative	proliferative	ADJ
bjp-23565	41	9	cell	cell	NOUN
bjp-23565	41	10	nuclear	nuclear	ADJ
bjp-23565	41	11	antigen	antigen	NOUN
bjp-23565	41	12	(	(	PUNCT
bjp-23565	41	13	pcna	pcna	PROPN
bjp-23565	41	14	)	)	PUNCT
bjp-23565	41	15	,	,	PUNCT
bjp-23565	41	16	cmyc	cmyc	PROPN
bjp-23565	41	17	,	,	PUNCT
bjp-23565	41	18	p21	p21	NOUN
bjp-23565	41	19	and	and	CCONJ
bjp-23565	41	20	cyclin	cyclin	NOUN
bjp-23565	41	21	,	,	PUNCT
bjp-23565	41	22	ly294002	ly294002	NOUN
bjp-23565	41	23	and	and	CCONJ
bjp-23565	41	24	β	β	NOUN
bjp-23565	41	25	-	-	ADJ
bjp-23565	41	26	actin	actin	ADJ
bjp-23565	41	27	antibody	antibody	NOUN
bjp-23565	41	28	were	be	AUX
bjp-23565	41	29	purchased	purchase	VERB
bjp-23565	41	30	from	from	ADP
bjp-23565	41	31	cell	cell	NOUN
bjp-23565	41	32	signaling	signal	VERB
bjp-23565	41	33	technology	technology	NOUN
bjp-23565	41	34	(	(	PUNCT
bjp-23565	41	35	cst	cst	PROPN
bjp-23565	41	36	)	)	PUNCT
bjp-23565	41	37	and	and	CCONJ
bjp-23565	41	38	santa	santa	PROPN
bjp-23565	41	39	cruz	cruz	PROPN
bjp-23565	41	40	biotechnology	biotechnology	PROPN
bjp-23565	41	41	(	(	PUNCT
bjp-23565	41	42	usa	usa	PROPN
bjp-23565	41	43	)	)	PUNCT
bjp-23565	41	44	.	.	PUNCT
bjp-23565	42	1	cell	cell	NOUN
bjp-23565	42	2	lines	line	NOUN
bjp-23565	42	3	and	and	CCONJ
bjp-23565	42	4	cell	cell	NOUN
bjp-23565	42	5	cultures	culture	NOUN
bjp-23565	42	6	the	the	DET
bjp-23565	42	7	estrogen	estrogen	NOUN
bjp-23565	42	8	receptor	receptor	NOUN
bjp-23565	42	9	alpha	alpha	NOUN
bjp-23565	42	10	positive	positive	ADJ
bjp-23565	42	11	(	(	PUNCT
bjp-23565	42	12	er+	er+	NOUN
bjp-23565	42	13	)	)	PUNCT
bjp-23565	42	14	,	,	PUNCT
bjp-23565	42	15	t47d	t47d	PRON
bjp-23565	42	16	and	and	CCONJ
bjp-23565	42	17	estrogen	estrogen	NOUN
bjp-23565	42	18	receptor	receptor	NOUN
bjp-23565	42	19	alpha	alpha	NOUN
bjp-23565	42	20	negative	negative	ADJ
bjp-23565	42	21	(	(	PUNCT
bjp-23565	42	22	er-	er-	PROPN
bjp-23565	42	23	)	)	PUNCT
bjp-23565	42	24	,	,	PUNCT
bjp-23565	42	25	hs0578	hs0578	PROPN
bjp-23565	42	26	t	t	PROPN
bjp-23565	42	27	human	human	PROPN
bjp-23565	42	28	breast	breast	PROPN
bjp-23565	42	29	cancer	cancer	NOUN
bjp-23565	42	30	cell	cell	NOUN
bjp-23565	42	31	lines	line	NOUN
bjp-23565	42	32	were	be	AUX
bjp-23565	42	33	obtained	obtain	VERB
bjp-23565	42	34	from	from	ADP
bjp-23565	42	35	american	american	ADJ
bjp-23565	42	36	type	type	NOUN
bjp-23565	42	37	culture	culture	NOUN
bjp-23565	42	38	collection	collection	NOUN
bjp-23565	42	39	(	(	PUNCT
bjp-23565	42	40	usa	usa	PROPN
bjp-23565	42	41	)	)	PUNCT
bjp-23565	42	42	.	.	PUNCT
bjp-23565	43	1	both	both	CCONJ
bjp-23565	43	2	the	the	DET
bjp-23565	43	3	cell	cell	NOUN
bjp-23565	43	4	lines	line	NOUN
bjp-23565	43	5	were	be	AUX
bjp-23565	43	6	grown	grow	VERB
bjp-23565	43	7	in	in	ADP
bjp-23565	43	8	dmem	dmem	VERB
bjp-23565	43	9	with	with	ADP
bjp-23565	43	10	10	10	NUM
bjp-23565	43	11	%	%	NOUN
bjp-23565	43	12	fbs	fbs	ADJ
bjp-23565	43	13	,	,	PUNCT
bjp-23565	43	14	2	2	NUM
bjp-23565	43	15	mm	mm	NOUN
bjp-23565	43	16	glutamine	glutamine	NOUN
bjp-23565	43	17	and	and	CCONJ
bjp-23565	43	18	antibiotics	antibiotic	NOUN
bjp-23565	43	19	(	(	PUNCT
bjp-23565	43	20	penicillin	penicillin	NOUN
bjp-23565	43	21	100	100	NUM
bjp-23565	43	22	u	u	NOUN
bjp-23565	43	23	/	/	SYM
bjp-23565	43	24	ml	ml	PROPN
bjp-23565	43	25	and	and	CCONJ
bjp-23565	43	26	streptomycin	streptomycin	PROPN
bjp-23565	43	27	50	50	NUM
bjp-23565	43	28	mg	mg	NUM
bjp-23565	43	29	/	/	SYM
bjp-23565	43	30	ml	ml	NOUN
bjp-23565	43	31	)	)	PUNCT
bjp-23565	43	32	at	at	ADP
bjp-23565	43	33	37	37	NUM
bjp-23565	43	34	°	°	ADP
bjp-23565	43	35	c	c	NOUN
bjp-23565	43	36	in	in	ADP
bjp-23565	43	37	a	a	DET
bjp-23565	43	38	humidified	humidified	ADJ
bjp-23565	43	39	5	5	NUM
bjp-23565	43	40	%	%	NOUN
bjp-23565	43	41	co2	co2	NOUN
bjp-23565	43	42	in	in	ADP
bjp-23565	43	43	air	air	NOUN
bjp-23565	43	44	atmosphere	atmosphere	NOUN
bjp-23565	43	45	.	.	PUNCT
bjp-23565	44	1	radioimmunoprecipitation	radioimmunoprecipitation	NOUN
bjp-23565	44	2	and	and	CCONJ
bjp-23565	44	3	western	western	ADJ
bjp-23565	44	4	blot	blot	NOUN
bjp-23565	44	5	cells	cell	NOUN
bjp-23565	44	6	were	be	AUX
bjp-23565	44	7	cultured	cultured	ADJ
bjp-23565	44	8	in	in	ADP
bjp-23565	44	9	dishes	dish	NOUN
bjp-23565	44	10	containing	contain	VERB
bjp-23565	44	11	growth	growth	NOUN
bjp-23565	44	12	medium	medium	NOUN
bjp-23565	44	13	at	at	ADP
bjp-23565	44	14	a	a	DET
bjp-23565	44	15	density	density	NOUN
bjp-23565	44	16	of	of	ADP
bjp-23565	44	17	1	1	NUM
bjp-23565	44	18	x	x	SYM
bjp-23565	44	19	105	105	NUM
bjp-23565	44	20	per	per	ADP
bjp-23565	44	21	dish	dish	NOUN
bjp-23565	44	22	overnight	overnight	ADV
bjp-23565	44	23	.	.	PUNCT
bjp-23565	45	1	the	the	DET
bjp-23565	45	2	cells	cell	NOUN
bjp-23565	45	3	were	be	AUX
bjp-23565	45	4	washed	wash	VERB
bjp-23565	45	5	twice	twice	ADV
bjp-23565	45	6	with	with	ADP
bjp-23565	45	7	medium	medium	NOUN
bjp-23565	45	8	without	without	ADP
bjp-23565	45	9	serum	serum	NOUN
bjp-23565	45	10	and	and	CCONJ
bjp-23565	45	11	starved	starve	VERB
bjp-23565	45	12	by	by	ADP
bjp-23565	45	13	incubating	incubate	VERB
bjp-23565	45	14	them	they	PRON
bjp-23565	45	15	in	in	ADP
bjp-23565	45	16	5	5	NUM
bjp-23565	45	17	ml	ml	NOUN
bjp-23565	45	18	of	of	ADP
bjp-23565	45	19	the	the	DET
bjp-23565	45	20	same	same	ADJ
bjp-23565	45	21	medium	medium	NOUN
bjp-23565	45	22	.	.	PUNCT
bjp-23565	46	1	after	after	ADP
bjp-23565	46	2	starvation	starvation	NOUN
bjp-23565	46	3	,	,	PUNCT
bjp-23565	46	4	the	the	DET
bjp-23565	46	5	cells	cell	NOUN
bjp-23565	46	6	were	be	AUX
bjp-23565	46	7	treated	treat	VERB
bjp-23565	46	8	with	with	ADP
bjp-23565	46	9	dmso	dmso	NOUN
bjp-23565	46	10	(	(	PUNCT
bjp-23565	46	11	vehicle	vehicle	NOUN
bjp-23565	46	12	)	)	PUNCT
bjp-23565	46	13	,	,	PUNCT
bjp-23565	46	14	1	1	NUM
bjp-23565	46	15	mm	mm	NOUN
bjp-23565	46	16	paclitaxel	paclitaxel	NOUN
bjp-23565	46	17	and	and	CCONJ
bjp-23565	46	18	5	5	NUM
bjp-23565	46	19	mm	mm	NOUN
bjp-23565	46	20	trastuzumab	trastuzumab	NOUN
bjp-23565	46	21	in	in	ADP
bjp-23565	46	22	1:1	1:1	NUM
bjp-23565	46	23	ratio	ratio	NOUN
bjp-23565	46	24	for	for	ADP
bjp-23565	46	25	t47d	t47d	DET
bjp-23565	46	26	cells	cell	NOUN
bjp-23565	46	27	and	and	CCONJ
bjp-23565	46	28	5	5	NUM
bjp-23565	46	29	mm	mm	NOUN
bjp-23565	46	30	and	and	CCONJ
bjp-23565	46	31	10	10	NUM
bjp-23565	46	32	mm	mm	NOUN
bjp-23565	46	33	at	at	ADP
bjp-23565	46	34	1:2	1:2	NUM
bjp-23565	46	35	ratio	ratio	NOUN
bjp-23565	46	36	for	for	ADP
bjp-23565	46	37	hs0578	hs0578	PROPN
bjp-23565	46	38	t	t	NOUN
bjp-23565	46	39	cells	cell	NOUN
bjp-23565	46	40	.	.	PUNCT
bjp-23565	47	1	the	the	DET
bjp-23565	47	2	drug	drug	NOUN
bjp-23565	47	3	combination	combination	NOUN
bjp-23565	47	4	effect	effect	NOUN
bjp-23565	47	5	between	between	ADP
bjp-23565	47	6	paclitaxel	paclitaxel	PROPN
bjp-23565	47	7	and	and	CCONJ
bjp-23565	47	8	trastuzumab	trastuzumab	NOUN
bjp-23565	47	9	was	be	AUX
bjp-23565	47	10	evaluated	evaluate	VERB
bjp-23565	47	11	for	for	ADP
bjp-23565	47	12	the	the	DET
bjp-23565	47	13	level	level	NOUN
bjp-23565	47	14	of	of	ADP
bjp-23565	47	15	interaction	interaction	NOUN
bjp-23565	47	16	(	(	PUNCT
bjp-23565	47	17	synergistic	synergistic	ADJ
bjp-23565	47	18	,	,	PUNCT
bjp-23565	47	19	additive	additive	ADJ
bjp-23565	47	20	or	or	CCONJ
bjp-23565	47	21	antagonistic	antagonistic	ADJ
bjp-23565	47	22	)	)	PUNCT
bjp-23565	47	23	,	,	PUNCT
bjp-23565	47	24	a	a	DET
bjp-23565	47	25	method	method	NOUN
bjp-23565	47	26	proposed	propose	VERB
bjp-23565	47	27	by	by	ADP
bjp-23565	47	28	chou	chou	PROPN
bjp-23565	47	29	(	(	PUNCT
bjp-23565	47	30	2006	2006	NUM
bjp-23565	47	31	)	)	PUNCT
bjp-23565	47	32	was	be	AUX
bjp-23565	47	33	followed	follow	VERB
bjp-23565	47	34	.	.	PUNCT
bjp-23565	48	1	the	the	DET
bjp-23565	48	2	cells	cell	NOUN
bjp-23565	48	3	lysed	lyse	VERB
bjp-23565	48	4	after	after	ADP
bjp-23565	48	5	24	24	NUM
bjp-23565	48	6	hours	hour	NOUN
bjp-23565	48	7	of	of	ADP
bjp-23565	48	8	drug	drug	NOUN
bjp-23565	48	9	treatment	treatment	NOUN
bjp-23565	48	10	by	by	ADP
bjp-23565	48	11	using	use	VERB
bjp-23565	48	12	radio	radio	NOUN
bjp-23565	48	13	immunoprecipitation	immunoprecipitation	NOUN
bjp-23565	48	14	assay	assay	NOUN
bjp-23565	48	15	(	(	PUNCT
bjp-23565	48	16	ripa	ripa	NOUN
bjp-23565	48	17	)	)	PUNCT
bjp-23565	48	18	buffer	buffer	NOUN
bjp-23565	48	19	containing	contain	VERB
bjp-23565	48	20	protease	protease	NOUN
bjp-23565	48	21	and	and	CCONJ
bjp-23565	48	22	phosphatase	phosphatase	NOUN
bjp-23565	48	23	inhibitor	inhibitor	NOUN
bjp-23565	48	24	cocktails	cocktail	NOUN
bjp-23565	48	25	.	.	PUNCT
bjp-23565	49	1	the	the	DET
bjp-23565	49	2	protein	protein	NOUN
bjp-23565	49	3	concentration	concentration	NOUN
bjp-23565	49	4	was	be	AUX
bjp-23565	49	5	determined	determine	VERB
bjp-23565	49	6	by	by	ADP
bjp-23565	49	7	lowry	lowry	PROPN
bjp-23565	49	8	’s	’s	PART
bjp-23565	49	9	method	method	NOUN
bjp-23565	49	10	(	(	PUNCT
bjp-23565	49	11	lowry	lowry	PROPN
bjp-23565	49	12	et	et	PROPN
bjp-23565	49	13	al	al	PROPN
bjp-23565	49	14	.	.	PROPN
bjp-23565	49	15	,	,	PUNCT
bjp-23565	49	16	1951	1951	NUM
bjp-23565	49	17	)	)	PUNCT
bjp-23565	49	18	.	.	PUNCT
bjp-23565	50	1	fifty	fifty	NUM
bjp-23565	50	2	milligram	milligram	NOUN
bjp-23565	50	3	of	of	ADP
bjp-23565	50	4	cell	cell	NOUN
bjp-23565	50	5	lysates	lysate	NOUN
bjp-23565	50	6	were	be	AUX
bjp-23565	50	7	loaded	load	VERB
bjp-23565	50	8	in	in	ADP
bjp-23565	50	9	12	12	NUM
bjp-23565	50	10	%	%	NOUN
bjp-23565	50	11	sdspage	sdspage	NOUN
bjp-23565	50	12	and	and	CCONJ
bjp-23565	50	13	transferred	transfer	VERB
bjp-23565	50	14	to	to	ADP
bjp-23565	50	15	pvdf	pvdf	PROPN
bjp-23565	50	16	membrane	membrane	NOUN
bjp-23565	50	17	.	.	PUNCT
bjp-23565	51	1	the	the	DET
bjp-23565	51	2	membranes	membrane	NOUN
bjp-23565	51	3	with	with	ADP
bjp-23565	51	4	transferred	transfer	VERB
bjp-23565	51	5	proteins	protein	NOUN
bjp-23565	51	6	were	be	AUX
bjp-23565	51	7	incubated	incubate	VERB
bjp-23565	51	8	with	with	ADP
bjp-23565	51	9	primary	primary	ADJ
bjp-23565	51	10	antibodies	antibody	NOUN
bjp-23565	51	11	against	against	ADP
bjp-23565	51	12	igf	igf	NOUN
bjp-23565	51	13	signaling	signal	VERB
bjp-23565	51	14	molecules	molecule	NOUN
bjp-23565	51	15	and	and	CCONJ
bjp-23565	51	16	β	β	NOUN
bjp-23565	51	17	-	-	NOUN
bjp-23565	51	18	actin	actin	NOUN
bjp-23565	51	19	in	in	ADP
bjp-23565	51	20	tris	tris	ADJ
bjp-23565	51	21	buffered	buffer	VERB
bjp-23565	51	22	saline	saline	NOUN
bjp-23565	51	23	.	.	PUNCT
bjp-23565	52	1	after	after	ADP
bjp-23565	52	2	incubation	incubation	NOUN
bjp-23565	52	3	,	,	PUNCT
bjp-23565	52	4	the	the	DET
bjp-23565	52	5	membranes	membrane	NOUN
bjp-23565	52	6	were	be	AUX
bjp-23565	52	7	washed	wash	VERB
bjp-23565	52	8	and	and	CCONJ
bjp-23565	52	9	incubated	incubate	VERB
bjp-23565	52	10	with	with	ADP
bjp-23565	52	11	hrp	hrp	PROPN
bjp-23565	52	12	-	-	PUNCT
bjp-23565	52	13	conjugated	conjugate	VERB
bjp-23565	52	14	with	with	ADP
bjp-23565	52	15	anti	anti	ADJ
bjp-23565	52	16	-	-	ADJ
bjp-23565	52	17	mouse	mouse	ADJ
bjp-23565	52	18	igg	igg	NOUN
bjp-23565	52	19	in	in	ADP
bjp-23565	52	20	1:5000	1:5000	NUM
bjp-23565	52	21	dilution	dilution	NOUN
bjp-23565	52	22	and	and	CCONJ
bjp-23565	52	23	goat	goat	NOUN
bjp-23565	52	24	anti	anti	ADJ
bjp-23565	52	25	-	-	ADJ
bjp-23565	52	26	rabbit	rabbit	ADJ
bjp-23565	52	27	igg	igg	NOUN
bjp-23565	52	28	in	in	ADP
bjp-23565	52	29	1:5000	1:5000	NUM
bjp-23565	52	30	dilution	dilution	NOUN
bjp-23565	52	31	.	.	PUNCT
bjp-23565	53	1	the	the	DET
bjp-23565	53	2	bands	band	NOUN
bjp-23565	53	3	were	be	AUX
bjp-23565	53	4	visualized	visualize	VERB
bjp-23565	53	5	using	use	VERB
bjp-23565	53	6	the	the	DET
bjp-23565	53	7	ge	ge	PROPN
bjp-23565	53	8	chemiluminescence	chemiluminescence	PROPN
bjp-23565	53	9	(	(	PUNCT
bjp-23565	53	10	ecl	ecl	PROPN
bjp-23565	53	11	)	)	PUNCT
bjp-23565	53	12	kit	kit	NOUN
bjp-23565	53	13	(	(	PUNCT
bjp-23565	53	14	ge	ge	PROPN
bjp-23565	53	15	healthcare	healthcare	PROPN
bjp-23565	53	16	life	life	PROPN
bjp-23565	53	17	sciences	sciences	PROPN
bjp-23565	53	18	,	,	PUNCT
bjp-23565	53	19	new	new	PROPN
bjp-23565	53	20	jersey	jersey	PROPN
bjp-23565	53	21	,	,	PUNCT
bjp-23565	53	22	usa	usa	PROPN
bjp-23565	53	23	)	)	PUNCT
bjp-23565	53	24	.	.	PUNCT
bjp-23565	54	1	growth	growth	NOUN
bjp-23565	54	2	factor	factor	NOUN
bjp-23565	54	3	,	,	PUNCT
bjp-23565	54	4	pi3k	pi3k	NOUN
bjp-23565	54	5	inhibitor	inhibitor	NOUN
bjp-23565	54	6	and	and	CCONJ
bjp-23565	54	7	drug	drug	NOUN
bjp-23565	54	8	treatment	treatment	NOUN
bjp-23565	54	9	cells	cell	NOUN
bjp-23565	54	10	were	be	AUX
bjp-23565	54	11	cultured	cultured	ADJ
bjp-23565	54	12	in	in	ADP
bjp-23565	54	13	dishes	dish	NOUN
bjp-23565	54	14	containing	contain	VERB
bjp-23565	54	15	growth	growth	NOUN
bjp-23565	54	16	medium	medium	NOUN
bjp-23565	54	17	at	at	ADP
bjp-23565	54	18	a	a	DET
bjp-23565	54	19	density	density	NOUN
bjp-23565	54	20	of	of	ADP
bjp-23565	54	21	1	1	NUM
bjp-23565	54	22	x	x	SYM
bjp-23565	54	23	105	105	NUM
bjp-23565	54	24	per	per	ADP
bjp-23565	54	25	dish	dish	NOUN
bjp-23565	54	26	.	.	PUNCT
bjp-23565	55	1	after	after	ADP
bjp-23565	55	2	starving	starve	VERB
bjp-23565	55	3	,	,	PUNCT
bjp-23565	55	4	the	the	DET
bjp-23565	55	5	cells	cell	NOUN
bjp-23565	55	6	were	be	AUX
bjp-23565	55	7	pretreated	pretreate	VERB
bjp-23565	55	8	with	with	ADP
bjp-23565	55	9	or	or	CCONJ
bjp-23565	55	10	without	without	ADP
bjp-23565	55	11	the	the	DET
bjp-23565	55	12	growth	growth	NOUN
bjp-23565	55	13	factor	factor	NOUN
bjp-23565	55	14	,	,	PUNCT
bjp-23565	55	15	igf-1	igf-1	ADV
bjp-23565	55	16	(	(	PUNCT
bjp-23565	55	17	50	50	NUM
bjp-23565	55	18	ng	ng	NOUN
bjp-23565	55	19	/	/	SYM
bjp-23565	55	20	ml	ml	PROPN
bjp-23565	55	21	)	)	PUNCT
bjp-23565	55	22	,	,	PUNCT
bjp-23565	55	23	50	50	NUM
bjp-23565	55	24	mm	mm	NOUN
bjp-23565	55	25	of	of	ADP
bjp-23565	55	26	pi3k	pi3k	PROPN
bjp-23565	55	27	inhibitor	inhibitor	NOUN
bjp-23565	55	28	,	,	PUNCT
bjp-23565	55	29	ly294002	ly294002	NOUN
bjp-23565	55	30	for	for	ADP
bjp-23565	55	31	1	1	NUM
bjp-23565	55	32	hour	hour	NOUN
bjp-23565	55	33	in	in	ADP
bjp-23565	55	34	cell	cell	NOUN
bjp-23565	55	35	culture	culture	NOUN
bjp-23565	55	36	medium	medium	NOUN
bjp-23565	55	37	.	.	PUNCT
bjp-23565	56	1	after	after	ADP
bjp-23565	56	2	pretreatment	pretreatment	NOUN
bjp-23565	56	3	,	,	PUNCT
bjp-23565	56	4	paclitaxel	paclitaxel	NOUN
bjp-23565	56	5	and	and	CCONJ
bjp-23565	56	6	trastuzumab	trastuzumab	NOUN
bjp-23565	56	7	were	be	AUX
bjp-23565	56	8	added	add	VERB
bjp-23565	56	9	at	at	ADP
bjp-23565	56	10	1	1	NUM
bjp-23565	56	11	mm	mm	NOUN
bjp-23565	56	12	and	and	CCONJ
bjp-23565	56	13	5	5	NUM
bjp-23565	56	14	mm	mm	NOUN
bjp-23565	56	15	for	for	ADP
bjp-23565	56	16	t47d	t47d	DET
bjp-23565	56	17	cells	cell	NOUN
bjp-23565	56	18	and	and	CCONJ
bjp-23565	56	19	5	5	NUM
bjp-23565	56	20	mm	mm	NOUN
bjp-23565	56	21	and	and	CCONJ
bjp-23565	56	22	10	10	NUM
bjp-23565	56	23	mm	mm	NOUN
bjp-23565	56	24	for	for	ADP
bjp-23565	56	25	hs0578	hs0578	PROPN
bjp-23565	56	26	t	t	NOUN
bjp-23565	56	27	cells	cell	NOUN
bjp-23565	56	28	respectively	respectively	ADV
bjp-23565	56	29	.	.	PUNCT
bjp-23565	57	1	after	after	ADP
bjp-23565	57	2	24	24	NUM
bjp-23565	57	3	hours	hour	NOUN
bjp-23565	57	4	,	,	PUNCT
bjp-23565	57	5	the	the	DET
bjp-23565	57	6	intracellular	intracellular	ADJ
bjp-23565	57	7	proteins	protein	NOUN
bjp-23565	57	8	were	be	AUX
bjp-23565	57	9	obtained	obtain	VERB
bjp-23565	57	10	by	by	ADP
bjp-23565	57	11	cell	cell	NOUN
bjp-23565	57	12	lysis	lysis	NOUN
bjp-23565	57	13	using	use	VERB
bjp-23565	57	14	ripa	ripa	ADJ
bjp-23565	57	15	buffer	buffer	NOUN
bjp-23565	57	16	with	with	ADP
bjp-23565	57	17	protease	protease	NOUN
bjp-23565	57	18	and	and	CCONJ
bjp-23565	57	19	phosphatase	phosphatase	NOUN
bjp-23565	57	20	inhibitor	inhibitor	NOUN
bjp-23565	57	21	.	.	PUNCT
bjp-23565	58	1	flow	flow	VERB
bjp-23565	58	2	cytometry	cytometry	NOUN
bjp-23565	58	3	cells	cell	NOUN
bjp-23565	58	4	were	be	AUX
bjp-23565	58	5	cultured	cultured	ADJ
bjp-23565	58	6	in	in	ADP
bjp-23565	58	7	dishes	dish	NOUN
bjp-23565	58	8	containing	contain	VERB
bjp-23565	58	9	growth	growth	NOUN
bjp-23565	58	10	medium	medium	NOUN
bjp-23565	58	11	at	at	ADP
bjp-23565	58	12	a	a	DET
bjp-23565	58	13	density	density	NOUN
bjp-23565	58	14	of	of	ADP
bjp-23565	58	15	1	1	NUM
bjp-23565	58	16	x	x	SYM
bjp-23565	58	17	105	105	NUM
bjp-23565	58	18	per	per	ADP
bjp-23565	58	19	dish	dish	NOUN
bjp-23565	58	20	.	.	PUNCT
bjp-23565	59	1	after	after	ADP
bjp-23565	59	2	starvation	starvation	NOUN
bjp-23565	59	3	,	,	PUNCT
bjp-23565	59	4	it	it	PRON
bjp-23565	59	5	was	be	AUX
bjp-23565	59	6	treated	treat	VERB
bjp-23565	59	7	with	with	ADP
bjp-23565	59	8	paclitaxel	paclitaxel	NOUN
bjp-23565	59	9	and	and	CCONJ
bjp-23565	59	10	trastuzumab	trastuzumab	NOUN
bjp-23565	59	11	at	at	ADP
bjp-23565	59	12	1	1	NUM
bjp-23565	59	13	mm	mm	NOUN
bjp-23565	59	14	and	and	CCONJ
bjp-23565	59	15	5	5	NUM
bjp-23565	59	16	mm	mm	NOUN
bjp-23565	59	17	for	for	ADP
bjp-23565	59	18	t47d	t47d	DET
bjp-23565	59	19	cells	cell	NOUN
bjp-23565	59	20	and	and	CCONJ
bjp-23565	59	21	5	5	NUM
bjp-23565	59	22	mm	mm	NOUN
bjp-23565	59	23	and	and	CCONJ
bjp-23565	59	24	10	10	NUM
bjp-23565	59	25	mm	mm	NOUN
bjp-23565	59	26	for	for	ADP
bjp-23565	59	27	hs0578	hs0578	PROPN
bjp-23565	59	28	t	t	NOUN
bjp-23565	59	29	cells	cell	NOUN
bjp-23565	59	30	respectively	respectively	ADV
bjp-23565	59	31	and	and	CCONJ
bjp-23565	59	32	kept	keep	VERB
bjp-23565	59	33	overnight	overnight	ADV
bjp-23565	59	34	.	.	PUNCT
bjp-23565	60	1	the	the	DET
bjp-23565	60	2	cells	cell	NOUN
bjp-23565	60	3	were	be	AUX
bjp-23565	60	4	harvested	harvest	VERB
bjp-23565	60	5	with	with	ADP
bjp-23565	60	6	0.25	0.25	NUM
bjp-23565	60	7	%	%	NOUN
bjp-23565	60	8	trypsin	trypsin	NOUN
bjp-23565	60	9	and	and	CCONJ
bjp-23565	60	10	centrifuged	centrifuge	VERB
bjp-23565	60	11	at	at	ADP
bjp-23565	60	12	3,000	3,000	NUM
bjp-23565	60	13	xg	xg	NOUN
bjp-23565	60	14	for	for	ADP
bjp-23565	60	15	10	10	NUM
bjp-23565	60	16	min	min	NOUN
bjp-23565	60	17	and	and	CCONJ
bjp-23565	60	18	washed	wash	VERB
bjp-23565	60	19	with	with	ADP
bjp-23565	60	20	pbs	pbs	PROPN
bjp-23565	60	21	.	.	PUNCT
bjp-23565	61	1	using	use	VERB
bjp-23565	61	2	100	100	NUM
bjp-23565	61	3	%	%	NOUN
bjp-23565	61	4	ice	ice	NOUN
bjp-23565	61	5	-	-	PUNCT
bjp-23565	61	6	cold	cold	ADJ
bjp-23565	61	7	methanol	methanol	NOUN
bjp-23565	61	8	the	the	DET
bjp-23565	61	9	cells	cell	NOUN
bjp-23565	61	10	were	be	AUX
bjp-23565	61	11	fixed	fix	VERB
bjp-23565	61	12	overnight	overnight	ADV
bjp-23565	61	13	at	at	ADP
bjp-23565	61	14	-20	-20	NUM
bjp-23565	61	15	°	°	NOUN
bjp-23565	61	16	c	c	NOUN
bjp-23565	61	17	and	and	CCONJ
bjp-23565	61	18	incubated	incubate	VERB
bjp-23565	61	19	with	with	ADP
bjp-23565	61	20	50	50	NUM
bjp-23565	61	21	mg	mg	NUM
bjp-23565	61	22	/	/	SYM
bjp-23565	61	23	ml	ml	NOUN
bjp-23565	61	24	of	of	ADP
bjp-23565	61	25	propidium	propidium	NOUN
bjp-23565	61	26	iodide	iodide	NOUN
bjp-23565	61	27	in	in	ADP
bjp-23565	61	28	pbs	pbs	PROPN
bjp-23565	61	29	and	and	CCONJ
bjp-23565	61	30	1	1	NUM
bjp-23565	61	31	mg	mg	NUM
bjp-23565	61	32	/	/	SYM
bjp-23565	61	33	ml	ml	PROPN
bjp-23565	61	34	of	of	ADP
bjp-23565	61	35	ribonuclease	ribonuclease	NOUN
bjp-23565	61	36	in	in	ADP
bjp-23565	61	37	pbs	pbs	PROPN
bjp-23565	61	38	for	for	ADP
bjp-23565	61	39	30	30	NUM
bjp-23565	61	40	min	min	NOUN
bjp-23565	61	41	.	.	PROPN
bjp-23565	61	42	cell	cell	NOUN
bjp-23565	61	43	cycle	cycle	NOUN
bjp-23565	61	44	analyses	analysis	NOUN
bjp-23565	61	45	was	be	AUX
bjp-23565	61	46	performed	perform	VERB
bjp-23565	61	47	on	on	ADP
bjp-23565	61	48	facscanto	facscanto	PROPN
bjp-23565	61	49	ii	ii	PROPN
bjp-23565	61	50	(	(	PUNCT
bjp-23565	61	51	bd	bd	PROPN
bjp-23565	61	52	biosciences	bioscience	NOUN
bjp-23565	61	53	,	,	PUNCT
bjp-23565	61	54	usa	usa	PROPN
bjp-23565	61	55	)	)	PUNCT
bjp-23565	61	56	.	.	PUNCT
bjp-23565	62	1	the	the	DET
bjp-23565	62	2	cells	cell	NOUN
bjp-23565	62	3	without	without	ADP
bjp-23565	62	4	staining	stain	VERB
bjp-23565	62	5	were	be	AUX
bjp-23565	62	6	used	use	VERB
bjp-23565	62	7	as	as	ADP
bjp-23565	62	8	a	a	DET
bjp-23565	62	9	control	control	NOUN
bjp-23565	62	10	.	.	PUNCT
bjp-23565	63	1	data	datum	NOUN
bjp-23565	63	2	analysis	analysis	NOUN
bjp-23565	63	3	was	be	AUX
bjp-23565	63	4	done	do	VERB
bjp-23565	63	5	using	use	VERB
bjp-23565	63	6	flowjo	flowjo	ADJ
bjp-23565	63	7	version	version	NOUN
bjp-23565	63	8	x	x	NOUN
bjp-23565	63	9	software	software	NOUN
bjp-23565	63	10	.	.	PUNCT
bjp-23565	64	1	statistical	statistical	ADJ
bjp-23565	64	2	analysis	analysis	NOUN
bjp-23565	64	3	statistical	statistical	ADJ
bjp-23565	64	4	analysis	analysis	NOUN
bjp-23565	64	5	was	be	AUX
bjp-23565	64	6	done	do	VERB
bjp-23565	64	7	by	by	ADP
bjp-23565	64	8	one	one	NUM
bjp-23565	64	9	way	way	NOUN
bjp-23565	64	10	anova	anova	PROPN
bjp-23565	64	11	followed	follow	VERB
bjp-23565	64	12	by	by	ADP
bjp-23565	64	13	multiple	multiple	ADJ
bjp-23565	64	14	comparison	comparison	NOUN
bjp-23565	64	15	by	by	ADP
bjp-23565	64	16	fisher	fisher	PROPN
bjp-23565	64	17	method	method	NOUN
bjp-23565	64	18	using	use	VERB
bjp-23565	64	19	stat	stat	PROPN
bjp-23565	64	20	view	view	NOUN
bjp-23565	64	21	software	software	NOUN
bjp-23565	64	22	(	(	PUNCT
bjp-23565	64	23	usa	usa	PROPN
bjp-23565	64	24	)	)	PUNCT
bjp-23565	64	25	.	.	PUNCT
bjp-23565	65	1	the	the	DET
bjp-23565	65	2	data	datum	NOUN
bjp-23565	65	3	were	be	AUX
bjp-23565	65	4	expressed	express	VERB
bjp-23565	65	5	as	as	ADP
bjp-23565	65	6	mean	mean	PROPN
bjp-23565	65	7	±	±	NUM
bjp-23565	65	8	sem	sem	NOUN
bjp-23565	65	9	.	.	PROPN
bjp-23565	65	10	800	800	NUM
bjp-23565	65	11	bangladesh	bangladesh	PROPN
bjp-23565	65	12	j	j	PROPN
bjp-23565	65	13	pharmacol	pharmacol	PROPN
bjp-23565	65	14	2015	2015	NUM
bjp-23565	65	15	;	;	PUNCT
bjp-23565	65	16	10	10	NUM
bjp-23565	65	17	:	:	PUNCT
bjp-23565	65	18	799	799	NUM
bjp-23565	65	19	-	-	SYM
bjp-23565	65	20	806	806	NUM
bjp-23565	65	21	results	result	VERB
bjp-23565	65	22	down	down	ADP
bjp-23565	65	23	-	-	PUNCT
bjp-23565	65	24	regulation	regulation	NOUN
bjp-23565	65	25	of	of	ADP
bjp-23565	65	26	igf-1rb	igf-1rb	NOUN
bjp-23565	65	27	,	,	PUNCT
bjp-23565	65	28	irs-2	irs-2	ADV
bjp-23565	65	29	,	,	PUNCT
bjp-23565	65	30	pi3k	pi3k	PROPN
bjp-23565	65	31	and	and	CCONJ
bjp-23565	65	32	upregulation	upregulation	NOUN
bjp-23565	65	33	of	of	ADP
bjp-23565	65	34	igfbp-3	igfbp-3	NUM
bjp-23565	65	35	and	and	CCONJ
bjp-23565	65	36	pten	pten	VERB
bjp-23565	65	37	by	by	ADP
bjp-23565	65	38	drug	drug	NOUN
bjp-23565	65	39	treatment	treatment	NOUN
bjp-23565	65	40	the	the	DET
bjp-23565	65	41	important	important	ADJ
bjp-23565	65	42	phenotypic	phenotypic	ADJ
bjp-23565	65	43	characteristics	characteristic	NOUN
bjp-23565	65	44	of	of	ADP
bjp-23565	65	45	metastatic	metastatic	ADJ
bjp-23565	65	46	phase	phase	NOUN
bjp-23565	65	47	in	in	ADP
bjp-23565	65	48	breast	breast	NOUN
bjp-23565	65	49	cancer	cancer	NOUN
bjp-23565	65	50	cells	cell	NOUN
bjp-23565	65	51	are	be	AUX
bjp-23565	65	52	regulated	regulate	VERB
bjp-23565	65	53	by	by	ADP
bjp-23565	65	54	igf	igf	PROPN
bjp-23565	65	55	system	system	NOUN
bjp-23565	65	56	which	which	PRON
bjp-23565	65	57	included	include	VERB
bjp-23565	65	58	survival	survival	NOUN
bjp-23565	65	59	,	,	PUNCT
bjp-23565	65	60	growth	growth	NOUN
bjp-23565	65	61	and	and	CCONJ
bjp-23565	65	62	metastasis	metastasis	NOUN
bjp-23565	65	63	(	(	PUNCT
bjp-23565	65	64	figueroa	figueroa	PROPN
bjp-23565	65	65	and	and	CCONJ
bjp-23565	65	66	yee	yee	PROPN
bjp-23565	65	67	,	,	PUNCT
bjp-23565	65	68	1992	1992	NUM
bjp-23565	65	69	)	)	PUNCT
bjp-23565	65	70	.	.	PUNCT
bjp-23565	66	1	igf-1rb	igf-1rb	NOUN
bjp-23565	66	2	is	be	AUX
bjp-23565	66	3	one	one	NUM
bjp-23565	66	4	of	of	ADP
bjp-23565	66	5	the	the	DET
bjp-23565	66	6	important	important	ADJ
bjp-23565	66	7	proteins	protein	NOUN
bjp-23565	66	8	involved	involve	VERB
bjp-23565	66	9	in	in	ADP
bjp-23565	66	10	igf	igf	PROPN
bjp-23565	66	11	signaling	signal	VERB
bjp-23565	66	12	in	in	ADP
bjp-23565	66	13	breast	breast	NOUN
bjp-23565	66	14	cancer	cancer	NOUN
bjp-23565	66	15	cells	cell	NOUN
bjp-23565	66	16	.	.	PUNCT
bjp-23565	67	1	figure	figure	NOUN
bjp-23565	67	2	1	1	NUM
bjp-23565	67	3	shows	show	VERB
bjp-23565	67	4	the	the	DET
bjp-23565	67	5	changes	change	NOUN
bjp-23565	67	6	in	in	ADP
bjp-23565	67	7	igf-1rb	igf-1rb	NOUN
bjp-23565	67	8	level	level	NOUN
bjp-23565	67	9	in	in	ADP
bjp-23565	67	10	both	both	CCONJ
bjp-23565	67	11	t47d	t47d	PRON
bjp-23565	67	12	and	and	CCONJ
bjp-23565	67	13	hs0578	hs0578	PROPN
bjp-23565	67	14	t	t	NOUN
bjp-23565	67	15	cell	cell	NOUN
bjp-23565	67	16	lines	line	NOUN
bjp-23565	67	17	after	after	ADP
bjp-23565	67	18	the	the	DET
bjp-23565	67	19	treatment	treatment	NOUN
bjp-23565	67	20	with	with	ADP
bjp-23565	67	21	combination	combination	NOUN
bjp-23565	67	22	of	of	ADP
bjp-23565	67	23	paclitaxel	paclitaxel	NOUN
bjp-23565	67	24	and	and	CCONJ
bjp-23565	67	25	trastuzumab	trastuzumab	NOUN
bjp-23565	67	26	.	.	PUNCT
bjp-23565	68	1	the	the	DET
bjp-23565	68	2	results	result	NOUN
bjp-23565	68	3	showed	show	VERB
bjp-23565	68	4	that	that	SCONJ
bjp-23565	68	5	igf-1rb	igf-1rb	NOUN
bjp-23565	68	6	protein	protein	NOUN
bjp-23565	68	7	expression	expression	NOUN
bjp-23565	68	8	was	be	AUX
bjp-23565	68	9	appreciably	appreciably	ADV
bjp-23565	68	10	lower	low	ADJ
bjp-23565	68	11	after	after	ADP
bjp-23565	68	12	the	the	DET
bjp-23565	68	13	drug	drug	NOUN
bjp-23565	68	14	treatment	treatment	NOUN
bjp-23565	68	15	after	after	ADP
bjp-23565	68	16	24	24	NUM
bjp-23565	68	17	hours	hour	NOUN
bjp-23565	68	18	in	in	ADP
bjp-23565	68	19	both	both	CCONJ
bjp-23565	68	20	t47d	t47d	PRON
bjp-23565	68	21	and	and	CCONJ
bjp-23565	68	22	hs0578	hs0578	PROPN
bjp-23565	68	23	t	t	NOUN
bjp-23565	68	24	cell	cell	NOUN
bjp-23565	68	25	lines	line	NOUN
bjp-23565	68	26	.	.	PUNCT
bjp-23565	69	1	the	the	DET
bjp-23565	69	2	protein	protein	NOUN
bjp-23565	69	3	igfbp-3	igfbp-3	PRON
bjp-23565	69	4	plays	play	VERB
bjp-23565	69	5	an	an	DET
bjp-23565	69	6	essential	essential	ADJ
bjp-23565	69	7	role	role	NOUN
bjp-23565	69	8	in	in	ADP
bjp-23565	69	9	controlling	control	VERB
bjp-23565	69	10	the	the	DET
bjp-23565	69	11	igfs	igfs	NOUN
bjp-23565	69	12	in	in	ADP
bjp-23565	69	13	its	its	PRON
bjp-23565	69	14	mitogenic	mitogenic	ADJ
bjp-23565	69	15	and	and	CCONJ
bjp-23565	69	16	anti	anti	ADJ
bjp-23565	69	17	-	-	ADJ
bjp-23565	69	18	apoptotic	apoptotic	ADJ
bjp-23565	69	19	effects	effect	NOUN
bjp-23565	69	20	by	by	ADP
bjp-23565	69	21	regulating	regulate	VERB
bjp-23565	69	22	their	their	PRON
bjp-23565	69	23	access	access	NOUN
bjp-23565	69	24	to	to	ADP
bjp-23565	69	25	the	the	DET
bjp-23565	69	26	igf-1	igf-1	NOUN
bjp-23565	69	27	receptor	receptor	NOUN
bjp-23565	69	28	.	.	PUNCT
bjp-23565	69	29	irs-2	irs-2	PUNCT
bjp-23565	69	30	and	and	CCONJ
bjp-23565	69	31	pi3k	pi3k	PROPN
bjp-23565	69	32	are	be	AUX
bjp-23565	69	33	the	the	DET
bjp-23565	69	34	signaling	signal	VERB
bjp-23565	69	35	molecules	molecule	NOUN
bjp-23565	69	36	intracellularly	intracellularly	ADV
bjp-23565	69	37	in	in	ADP
bjp-23565	69	38	igf	igf	PROPN
bjp-23565	69	39	pathway	pathway	NOUN
bjp-23565	69	40	.	.	PUNCT
bjp-23565	70	1	pten	pten	VERB
bjp-23565	70	2	negatively	negatively	ADV
bjp-23565	70	3	regulates	regulate	VERB
bjp-23565	70	4	pi3k	pi3k	PROPN
bjp-23565	70	5	/	/	SYM
bjp-23565	70	6	akt	akt	PROPN
bjp-23565	70	7	and	and	CCONJ
bjp-23565	70	8	acts	act	VERB
bjp-23565	70	9	as	as	ADP
bjp-23565	70	10	a	a	DET
bjp-23565	70	11	tumor	tumor	NOUN
bjp-23565	70	12	suppressor	suppressor	NOUN
bjp-23565	70	13	.	.	PUNCT
bjp-23565	71	1	the	the	DET
bjp-23565	71	2	results	result	NOUN
bjp-23565	71	3	showed	show	VERB
bjp-23565	71	4	that	that	SCONJ
bjp-23565	71	5	expression	expression	NOUN
bjp-23565	71	6	of	of	ADP
bjp-23565	71	7	igfbp-3	igfbp-3	NUM
bjp-23565	71	8	was	be	AUX
bjp-23565	71	9	higher	high	ADJ
bjp-23565	71	10	after	after	SCONJ
bjp-23565	71	11	the	the	DET
bjp-23565	71	12	combined	combined	ADJ
bjp-23565	71	13	treatment	treatment	NOUN
bjp-23565	71	14	of	of	ADP
bjp-23565	71	15	paclitaxel	paclitaxel	PROPN
bjp-23565	71	16	and	and	CCONJ
bjp-23565	71	17	trastuzumab	trastuzumab	NOUN
bjp-23565	71	18	treatment	treatment	NOUN
bjp-23565	71	19	and	and	CCONJ
bjp-23565	71	20	irs-2	irs-2	ADV
bjp-23565	71	21	and	and	CCONJ
bjp-23565	71	22	pi3k	pi3k	NOUN
bjp-23565	71	23	protein	protein	NOUN
bjp-23565	71	24	expression	expression	NOUN
bjp-23565	71	25	levels	level	NOUN
bjp-23565	71	26	were	be	AUX
bjp-23565	71	27	found	find	VERB
bjp-23565	71	28	to	to	PART
bjp-23565	71	29	be	be	AUX
bjp-23565	71	30	lowered	lower	VERB
bjp-23565	71	31	in	in	ADP
bjp-23565	71	32	treated	treat	VERB
bjp-23565	71	33	cells	cell	NOUN
bjp-23565	71	34	.	.	PUNCT
bjp-23565	72	1	interestingly	interestingly	ADV
bjp-23565	72	2	the	the	DET
bjp-23565	72	3	pten	pten	ADJ
bjp-23565	72	4	protein	protein	NOUN
bjp-23565	72	5	expression	expression	NOUN
bjp-23565	72	6	was	be	AUX
bjp-23565	72	7	markedly	markedly	ADV
bjp-23565	72	8	increased	increase	VERB
bjp-23565	72	9	in	in	ADP
bjp-23565	72	10	the	the	DET
bjp-23565	72	11	drug	drug	NOUN
bjp-23565	72	12	treated	treat	VERB
bjp-23565	72	13	cells	cell	NOUN
bjp-23565	72	14	(	(	PUNCT
bjp-23565	72	15	figure	figure	NOUN
bjp-23565	72	16	1	1	NUM
bjp-23565	72	17	)	)	PUNCT
bjp-23565	72	18	.	.	PUNCT
bjp-23565	73	1	collectively	collectively	ADV
bjp-23565	73	2	,	,	PUNCT
bjp-23565	73	3	it	it	PRON
bjp-23565	73	4	can	can	AUX
bjp-23565	73	5	be	be	AUX
bjp-23565	73	6	said	say	VERB
bjp-23565	73	7	that	that	SCONJ
bjp-23565	73	8	synergistic	synergistic	ADJ
bjp-23565	73	9	effects	effect	NOUN
bjp-23565	73	10	of	of	ADP
bjp-23565	73	11	paclitaxel	paclitaxel	NOUN
bjp-23565	73	12	and	and	CCONJ
bjp-23565	73	13	trastuzumab	trastuzumab	NOUN
bjp-23565	73	14	reduced	reduce	VERB
bjp-23565	73	15	igf-1	igf-1	NOUN
bjp-23565	73	16	downstream	downstream	ADJ
bjp-23565	73	17	molecules	molecule	NOUN
bjp-23565	73	18	and	and	CCONJ
bjp-23565	73	19	increased	increase	VERB
bjp-23565	73	20	the	the	DET
bjp-23565	73	21	igfnp-3	igfnp-3	PROPN
bjp-23565	73	22	and	and	CCONJ
bjp-23565	73	23	pten	pten	VERB
bjp-23565	73	24	protein	protein	NOUN
bjp-23565	73	25	levels	level	NOUN
bjp-23565	73	26	.	.	PUNCT
bjp-23565	74	1	hence	hence	ADV
bjp-23565	74	2	,	,	PUNCT
bjp-23565	74	3	the	the	DET
bjp-23565	74	4	combination	combination	NOUN
bjp-23565	74	5	of	of	ADP
bjp-23565	74	6	these	these	DET
bjp-23565	74	7	two	two	NUM
bjp-23565	74	8	drugs	drug	NOUN
bjp-23565	74	9	have	have	VERB
bjp-23565	74	10	the	the	DET
bjp-23565	74	11	potential	potential	NOUN
bjp-23565	74	12	to	to	PART
bjp-23565	74	13	inhibit	inhibit	VERB
bjp-23565	74	14	igf-1	igf-1	ADV
bjp-23565	74	15	mediated	mediate	VERB
bjp-23565	74	16	proliferation	proliferation	NOUN
bjp-23565	74	17	of	of	ADP
bjp-23565	74	18	breast	breast	NOUN
bjp-23565	74	19	cancer	cancer	NOUN
bjp-23565	74	20	cells	cell	NOUN
bjp-23565	74	21	used	use	VERB
bjp-23565	74	22	in	in	ADP
bjp-23565	74	23	this	this	DET
bjp-23565	74	24	study	study	NOUN
bjp-23565	74	25	.	.	PUNCT
bjp-23565	75	1	western	western	ADJ
bjp-23565	75	2	blot	blot	NOUN
bjp-23565	75	3	analyses	analyse	VERB
bjp-23565	75	4	western	western	ADJ
bjp-23565	75	5	blot	blot	NOUN
bjp-23565	75	6	was	be	AUX
bjp-23565	75	7	performed	perform	VERB
bjp-23565	75	8	to	to	PART
bjp-23565	75	9	find	find	VERB
bjp-23565	75	10	out	out	ADP
bjp-23565	75	11	the	the	DET
bjp-23565	75	12	protein	protein	NOUN
bjp-23565	75	13	expressions	expression	NOUN
bjp-23565	75	14	of	of	ADP
bjp-23565	75	15	mek	mek	PROPN
bjp-23565	75	16	,	,	PUNCT
bjp-23565	75	17	perk	perk	NOUN
bjp-23565	75	18	1	1	NUM
bjp-23565	75	19	and	and	CCONJ
bjp-23565	75	20	2	2	NUM
bjp-23565	75	21	,	,	PUNCT
bjp-23565	75	22	n	n	CCONJ
bjp-23565	75	23	-	-	PUNCT
bjp-23565	75	24	ras	ras	NOUN
bjp-23565	75	25	,	,	PUNCT
bjp-23565	75	26	p38	p38	NOUN
bjp-23565	75	27	and	and	CCONJ
bjp-23565	75	28	raf1	raf1	VERB
bjp-23565	75	29	in	in	ADP
bjp-23565	75	30	breast	breast	NOUN
bjp-23565	75	31	carcinoma	carcinoma	NOUN
bjp-23565	75	32	since	since	SCONJ
bjp-23565	75	33	these	these	PRON
bjp-23565	75	34	are	be	AUX
bjp-23565	75	35	the	the	DET
bjp-23565	75	36	main	main	ADJ
bjp-23565	75	37	downstream	downstream	ADJ
bjp-23565	75	38	signaling	signal	VERB
bjp-23565	75	39	molecules	molecule	NOUN
bjp-23565	75	40	during	during	ADP
bjp-23565	75	41	cell	cell	NOUN
bjp-23565	75	42	proliferation	proliferation	NOUN
bjp-23565	75	43	mediated	mediate	VERB
bjp-23565	75	44	by	by	ADP
bjp-23565	75	45	igf-1	igf-1	NOUN
bjp-23565	75	46	.	.	NOUN
bjp-23565	75	47	figure	figure	NOUN
bjp-23565	75	48	2	2	NUM
bjp-23565	75	49	shows	show	NOUN
bjp-23565	75	50	reduced	reduce	VERB
bjp-23565	75	51	expression	expression	NOUN
bjp-23565	75	52	of	of	ADP
bjp-23565	75	53	n	n	CCONJ
bjp-23565	75	54	-	-	PUNCT
bjp-23565	75	55	ras	ras	PROPN
bjp-23565	75	56	,	,	PUNCT
bjp-23565	75	57	mek	mek	PROPN
bjp-23565	75	58	,	,	PUNCT
bjp-23565	75	59	raf-1	raf-1	VERB
bjp-23565	75	60	and	and	CCONJ
bjp-23565	75	61	perk	perk	NOUN
bjp-23565	75	62	1	1	NUM
bjp-23565	75	63	and	and	CCONJ
bjp-23565	75	64	2	2	NUM
bjp-23565	75	65	and	and	CCONJ
bjp-23565	75	66	elevated	elevated	ADJ
bjp-23565	75	67	expression	expression	NOUN
bjp-23565	75	68	of	of	ADP
bjp-23565	75	69	p38	p38	NOUN
bjp-23565	75	70	after	after	ADP
bjp-23565	75	71	drug	drug	NOUN
bjp-23565	75	72	treatment	treatment	NOUN
bjp-23565	75	73	.	.	PUNCT
bjp-23565	76	1	figure	figure	NOUN
bjp-23565	76	2	3	3	NUM
bjp-23565	76	3	shows	show	VERB
bjp-23565	76	4	the	the	DET
bjp-23565	76	5	effect	effect	NOUN
bjp-23565	76	6	of	of	ADP
bjp-23565	76	7	pi3k	pi3k	PROPN
bjp-23565	76	8	inhibitor	inhibitor	NOUN
bjp-23565	76	9	and	and	CCONJ
bjp-23565	76	10	combination	combination	NOUN
bjp-23565	76	11	of	of	ADP
bjp-23565	76	12	two	two	NUM
bjp-23565	76	13	drugs	drug	NOUN
bjp-23565	76	14	on	on	ADP
bjp-23565	76	15	the	the	DET
bjp-23565	76	16	expression	expression	NOUN
bjp-23565	76	17	of	of	ADP
bjp-23565	76	18	pakt	pakt	NOUN
bjp-23565	76	19	protein	protein	NOUN
bjp-23565	76	20	.	.	PUNCT
bjp-23565	77	1	the	the	DET
bjp-23565	77	2	function	function	NOUN
bjp-23565	77	3	of	of	ADP
bjp-23565	77	4	akt	akt	PROPN
bjp-23565	77	5	signaling	signal	VERB
bjp-23565	77	6	is	be	AUX
bjp-23565	77	7	analyzed	analyze	VERB
bjp-23565	77	8	by	by	ADP
bjp-23565	77	9	using	use	VERB
bjp-23565	77	10	the	the	DET
bjp-23565	77	11	well	well	ADV
bjp-23565	77	12	-	-	PUNCT
bjp-23565	77	13	characterized	characterize	VERB
bjp-23565	77	14	pi3k	pi3k	NOUN
bjp-23565	77	15	inhibitor	inhibitor	NOUN
bjp-23565	77	16	,	,	PUNCT
bjp-23565	77	17	ly294002	ly294002	NOUN
bjp-23565	77	18	as	as	SCONJ
bjp-23565	77	19	akt	akt	PROPN
bjp-23565	77	20	protein	protein	NOUN
bjp-23565	77	21	helps	help	VERB
bjp-23565	77	22	in	in	ADP
bjp-23565	77	23	cell	cell	NOUN
bjp-23565	77	24	survival	survival	NOUN
bjp-23565	77	25	and	and	CCONJ
bjp-23565	77	26	breast	breast	NOUN
bjp-23565	77	27	cancer	cancer	NOUN
bjp-23565	77	28	cells	cell	NOUN
bjp-23565	77	29	expresses	express	VERB
bjp-23565	77	30	pakts	pakts	ADJ
bjp-23565	77	31	.	.	PUNCT
bjp-23565	78	1	activation	activation	NOUN
bjp-23565	78	2	of	of	ADP
bjp-23565	78	3	cell	cell	NOUN
bjp-23565	78	4	lines	line	NOUN
bjp-23565	78	5	with	with	ADP
bjp-23565	78	6	igf-1	igf-1	NOUN
bjp-23565	78	7	had	have	AUX
bjp-23565	78	8	elevated	elevate	VERB
bjp-23565	78	9	the	the	DET
bjp-23565	78	10	pakt	pakt	NOUN
bjp-23565	78	11	protein	protein	NOUN
bjp-23565	78	12	expression	expression	NOUN
bjp-23565	78	13	and	and	CCONJ
bjp-23565	78	14	the	the	DET
bjp-23565	78	15	pakt	pakt	NOUN
bjp-23565	78	16	expression	expression	NOUN
bjp-23565	78	17	was	be	AUX
bjp-23565	78	18	blocked	block	VERB
bjp-23565	78	19	by	by	ADP
bjp-23565	78	20	ly294002	ly294002	NOUN
bjp-23565	78	21	as	as	ADV
bjp-23565	78	22	well	well	ADV
bjp-23565	78	23	as	as	ADP
bjp-23565	78	24	paclitaxel	paclitaxel	NOUN
bjp-23565	78	25	and	and	CCONJ
bjp-23565	78	26	trastuzumab	trastuzumab	NOUN
bjp-23565	78	27	treatment	treatment	NOUN
bjp-23565	78	28	.	.	PUNCT
bjp-23565	79	1	hence	hence	ADV
bjp-23565	79	2	,	,	PUNCT
bjp-23565	79	3	the	the	DET
bjp-23565	79	4	combined	combined	ADJ
bjp-23565	79	5	effect	effect	NOUN
bjp-23565	79	6	of	of	ADP
bjp-23565	79	7	igf-1	igf-1	ADJ
bjp-23565	79	8	and	and	CCONJ
bjp-23565	79	9	the	the	DET
bjp-23565	79	10	two	two	NUM
bjp-23565	79	11	drugs	drug	NOUN
bjp-23565	79	12	were	be	AUX
bjp-23565	79	13	studied	study	VERB
bjp-23565	79	14	(	(	PUNCT
bjp-23565	79	15	figure	figure	NOUN
bjp-23565	79	16	3	3	NUM
bjp-23565	79	17	)	)	PUNCT
bjp-23565	79	18	.	.	PUNCT
bjp-23565	80	1	the	the	DET
bjp-23565	80	2	observed	observe	VERB
bjp-23565	80	3	result	result	NOUN
bjp-23565	80	4	supports	support	VERB
bjp-23565	80	5	that	that	SCONJ
bjp-23565	80	6	this	this	DET
bjp-23565	80	7	combination	combination	NOUN
bjp-23565	80	8	also	also	ADV
bjp-23565	80	9	affects	affect	VERB
bjp-23565	80	10	the	the	DET
bjp-23565	80	11	akt	akt	PROPN
bjp-23565	80	12	phosphorylation	phosphorylation	NOUN
bjp-23565	80	13	without	without	ADP
bjp-23565	80	14	affecting	affect	VERB
bjp-23565	80	15	its	its	PRON
bjp-23565	80	16	total	total	ADJ
bjp-23565	80	17	expression	expression	NOUN
bjp-23565	80	18	.	.	PUNCT
bjp-23565	81	1	hence	hence	ADV
bjp-23565	81	2	,	,	PUNCT
bjp-23565	81	3	the	the	DET
bjp-23565	81	4	total	total	ADJ
bjp-23565	81	5	akt	akt	PROPN
bjp-23565	81	6	was	be	AUX
bjp-23565	81	7	used	use	VERB
bjp-23565	81	8	to	to	PART
bjp-23565	81	9	normalize	normalize	VERB
bjp-23565	81	10	the	the	DET
bjp-23565	81	11	pakt	pakt	NOUN
bjp-23565	81	12	expression	expression	NOUN
bjp-23565	81	13	level	level	NOUN
bjp-23565	81	14	.	.	PUNCT
bjp-23565	82	1	paclitaxel	paclitaxel	PROPN
bjp-23565	82	2	and	and	CCONJ
bjp-23565	82	3	trastuzumab	trastuzumab	NOUN
bjp-23565	82	4	treatment	treatment	NOUN
bjp-23565	82	5	in	in	ADP
bjp-23565	82	6	the	the	DET
bjp-23565	82	7	presence	presence	NOUN
bjp-23565	82	8	of	of	ADP
bjp-23565	82	9	inhibitors	inhibitor	NOUN
bjp-23565	82	10	inhibited	inhibit	VERB
bjp-23565	82	11	the	the	DET
bjp-23565	82	12	akt	akt	PROPN
bjp-23565	82	13	phosphorylation	phosphorylation	NOUN
bjp-23565	82	14	and	and	CCONJ
bjp-23565	82	15	reduced	reduce	VERB
bjp-23565	82	16	the	the	DET
bjp-23565	82	17	survival	survival	NOUN
bjp-23565	82	18	rate	rate	NOUN
bjp-23565	82	19	of	of	ADP
bjp-23565	82	20	t47d	t47d	PRON
bjp-23565	82	21	and	and	CCONJ
bjp-23565	82	22	hs0578	hs0578	PROPN
bjp-23565	82	23	t	t	NOUN
bjp-23565	82	24	cells	cell	NOUN
bjp-23565	82	25	.	.	PUNCT
bjp-23565	83	1	effect	effect	NOUN
bjp-23565	83	2	of	of	ADP
bjp-23565	83	3	paclitaxel	paclitaxel	NOUN
bjp-23565	83	4	and	and	CCONJ
bjp-23565	83	5	trastuzumab	trastuzumab	NOUN
bjp-23565	83	6	on	on	ADP
bjp-23565	83	7	expression	expression	NOUN
bjp-23565	83	8	of	of	ADP
bjp-23565	83	9	cmyc	cmyc	NOUN
bjp-23565	83	10	and	and	CCONJ
bjp-23565	83	11	β	β	NOUN
bjp-23565	83	12	-	-	NOUN
bjp-23565	83	13	catenin	catenin	VERB
bjp-23565	83	14	the	the	DET
bjp-23565	83	15	igf-1	igf-1	ADV
bjp-23565	83	16	mediated	mediate	VERB
bjp-23565	83	17	cell	cell	NOUN
bjp-23565	83	18	proliferation	proliferation	NOUN
bjp-23565	83	19	has	have	VERB
bjp-23565	83	20	two	two	NUM
bjp-23565	83	21	downstream	downstream	ADJ
bjp-23565	83	22	molecules	molecule	NOUN
bjp-23565	83	23	,	,	PUNCT
bjp-23565	83	24	c	c	NOUN
bjp-23565	83	25	-	-	PUNCT
bjp-23565	83	26	myc	myc	NOUN
bjp-23565	83	27	and	and	CCONJ
bjp-23565	83	28	β	β	NOUN
bjp-23565	83	29	-	-	NOUN
bjp-23565	83	30	catenin	catenin	NOUN
bjp-23565	83	31	.	.	PUNCT
bjp-23565	84	1	the	the	DET
bjp-23565	84	2	effect	effect	NOUN
bjp-23565	84	3	of	of	ADP
bjp-23565	84	4	the	the	DET
bjp-23565	84	5	two	two	NUM
bjp-23565	84	6	drugs	drug	NOUN
bjp-23565	84	7	,	,	PUNCT
bjp-23565	84	8	paclitaxel	paclitaxel	NOUN
bjp-23565	84	9	and	and	CCONJ
bjp-23565	84	10	trastuzumab	trastuzumab	NOUN
bjp-23565	84	11	on	on	ADP
bjp-23565	84	12	expression	expression	NOUN
bjp-23565	84	13	of	of	ADP
bjp-23565	84	14	c	c	NOUN
bjp-23565	84	15	-	-	PUNCT
bjp-23565	84	16	myc	myc	NOUN
bjp-23565	84	17	and	and	CCONJ
bjp-23565	84	18	β	β	NOUN
bjp-23565	84	19	-	-	NOUN
bjp-23565	84	20	catenin	catenin	NOUN
bjp-23565	84	21	was	be	AUX
bjp-23565	84	22	studied	study	VERB
bjp-23565	84	23	in	in	ADP
bjp-23565	84	24	t47d	t47d	DET
bjp-23565	84	25	and	and	CCONJ
bjp-23565	84	26	hs078	hs078	PROPN
bjp-23565	84	27	t	t	NOUN
bjp-23565	84	28	cells	cell	NOUN
bjp-23565	84	29	.	.	PUNCT
bjp-23565	85	1	figure	figure	NOUN
bjp-23565	85	2	4	4	NUM
bjp-23565	85	3	shows	show	VERB
bjp-23565	85	4	the	the	DET
bjp-23565	85	5	results	result	NOUN
bjp-23565	85	6	of	of	ADP
bjp-23565	85	7	paclitaxel	paclitaxel	PROPN
bjp-23565	85	8	and	and	CCONJ
bjp-23565	85	9	figure	figure	VERB
bjp-23565	85	10	1	1	NUM
bjp-23565	85	11	:	:	PUNCT
bjp-23565	85	12	effect	effect	NOUN
bjp-23565	85	13	of	of	ADP
bjp-23565	85	14	paclitaxel	paclitaxel	NOUN
bjp-23565	85	15	and	and	CCONJ
bjp-23565	85	16	trastuzumab	trastuzumab	NOUN
bjp-23565	85	17	on	on	ADP
bjp-23565	85	18	protein	protein	NOUN
bjp-23565	85	19	expression	expression	NOUN
bjp-23565	85	20	of	of	ADP
bjp-23565	85	21	downstream	downstream	ADJ
bjp-23565	85	22	signaling	signal	VERB
bjp-23565	85	23	molecules	molecule	NOUN
bjp-23565	85	24	in	in	ADP
bjp-23565	85	25	igf	igf	PROPN
bjp-23565	85	26	mediated	mediate	VERB
bjp-23565	85	27	cell	cell	NOUN
bjp-23565	85	28	proliferation	proliferation	NOUN
bjp-23565	85	29	in	in	ADP
bjp-23565	85	30	t47d	t47d	PRON
bjp-23565	85	31	and	and	CCONJ
bjp-23565	85	32	hs0578	hs0578	PROPN
bjp-23565	85	33	t	t	NOUN
bjp-23565	85	34	cells	cell	NOUN
bjp-23565	85	35	by	by	ADP
bjp-23565	85	36	western	western	ADJ
bjp-23565	85	37	blot	blot	PROPN
bjp-23565	85	38	bangladesh	bangladesh	PROPN
bjp-23565	85	39	j	j	PROPN
bjp-23565	85	40	pharmacol	pharmacol	PROPN
bjp-23565	85	41	2015	2015	NUM
bjp-23565	85	42	;	;	PUNCT
bjp-23565	85	43	10	10	NUM
bjp-23565	85	44	:	:	PUNCT
bjp-23565	85	45	799	799	NUM
bjp-23565	85	46	-	-	SYM
bjp-23565	85	47	806	806	NUM
bjp-23565	85	48	801	801	NUM
bjp-23565	85	49	trastuzumab	trastuzumab	NOUN
bjp-23565	85	50	effect	effect	NOUN
bjp-23565	85	51	.	.	PUNCT
bjp-23565	86	1	we	we	PRON
bjp-23565	86	2	observed	observe	VERB
bjp-23565	86	3	decrease	decrease	NOUN
bjp-23565	86	4	in	in	ADP
bjp-23565	86	5	c	c	NOUN
bjp-23565	86	6	-	-	PUNCT
bjp-23565	86	7	myc	myc	NOUN
bjp-23565	86	8	and	and	CCONJ
bjp-23565	86	9	β	β	NOUN
bjp-23565	86	10	-	-	ADJ
bjp-23565	86	11	catenin	catenin	ADJ
bjp-23565	86	12	expression	expression	NOUN
bjp-23565	86	13	after	after	ADP
bjp-23565	86	14	the	the	DET
bjp-23565	86	15	drug	drug	NOUN
bjp-23565	86	16	treatment	treatment	NOUN
bjp-23565	86	17	in	in	ADP
bjp-23565	86	18	both	both	CCONJ
bjp-23565	86	19	t47d	t47d	PRON
bjp-23565	86	20	and	and	CCONJ
bjp-23565	86	21	hs078	hs078	PROPN
bjp-23565	86	22	t	t	NOUN
bjp-23565	86	23	cells	cell	NOUN
bjp-23565	86	24	.	.	PUNCT
bjp-23565	87	1	cell	cell	NOUN
bjp-23565	87	2	cycle	cycle	NOUN
bjp-23565	87	3	analyses	analysis	NOUN
bjp-23565	87	4	figure	figure	VERB
bjp-23565	87	5	5	5	NUM
bjp-23565	87	6	shows	show	NOUN
bjp-23565	87	7	increase	increase	VERB
bjp-23565	87	8	in	in	ADP
bjp-23565	87	9	number	number	NOUN
bjp-23565	87	10	of	of	ADP
bjp-23565	87	11	cells	cell	NOUN
bjp-23565	87	12	in	in	ADP
bjp-23565	87	13	the	the	DET
bjp-23565	87	14	g0/	g0/	X
bjp-23565	87	15	g1	g1	PROPN
bjp-23565	87	16	phase	phase	NOUN
bjp-23565	87	17	after	after	ADP
bjp-23565	87	18	the	the	DET
bjp-23565	87	19	drug	drug	NOUN
bjp-23565	87	20	treatment	treatment	NOUN
bjp-23565	87	21	in	in	ADP
bjp-23565	87	22	the	the	DET
bjp-23565	87	23	t47d	t47d	PROPN
bjp-23565	87	24	and	and	CCONJ
bjp-23565	87	25	hs078	hs078	PROPN
bjp-23565	87	26	t	t	NOUN
bjp-23565	87	27	cell	cell	NOUN
bjp-23565	87	28	lines	line	NOUN
bjp-23565	87	29	.	.	PUNCT
bjp-23565	88	1	the	the	DET
bjp-23565	88	2	treatment	treatment	NOUN
bjp-23565	88	3	showed	show	VERB
bjp-23565	88	4	66	66	NUM
bjp-23565	88	5	and	and	CCONJ
bjp-23565	88	6	53	53	NUM
bjp-23565	88	7	%	%	NOUN
bjp-23565	88	8	in	in	ADP
bjp-23565	88	9	t47d	t47d	DET
bjp-23565	88	10	and	and	CCONJ
bjp-23565	88	11	hs0578	hs0578	PROPN
bjp-23565	88	12	t	t	NOUN
bjp-23565	88	13	cells	cell	NOUN
bjp-23565	88	14	respectively	respectively	ADV
bjp-23565	88	15	in	in	ADP
bjp-23565	88	16	g0	g0	PROPN
bjp-23565	88	17	/	/	SYM
bjp-23565	88	18	g1	g1	PROPN
bjp-23565	88	19	phase	phase	NOUN
bjp-23565	88	20	.	.	PUNCT
bjp-23565	89	1	compared	compare	VERB
bjp-23565	89	2	with	with	ADP
bjp-23565	89	3	vehicle	vehicle	NOUN
bjp-23565	89	4	treated	treat	VERB
bjp-23565	89	5	cells	cell	NOUN
bjp-23565	89	6	,	,	PUNCT
bjp-23565	89	7	there	there	PRON
bjp-23565	89	8	was	be	VERB
bjp-23565	89	9	rise	rise	NOUN
bjp-23565	89	10	in	in	ADP
bjp-23565	89	11	dead	dead	ADJ
bjp-23565	89	12	cells	cell	NOUN
bjp-23565	89	13	by	by	ADP
bjp-23565	89	14	7.6	7.6	NUM
bjp-23565	89	15	%	%	NOUN
bjp-23565	89	16	and	and	CCONJ
bjp-23565	89	17	9.7	9.7	NUM
bjp-23565	89	18	%	%	NOUN
bjp-23565	89	19	in	in	ADP
bjp-23565	89	20	t47d	t47d	DET
bjp-23565	89	21	and	and	CCONJ
bjp-23565	89	22	hs0578	hs0578	PROPN
bjp-23565	89	23	t	t	NOUN
bjp-23565	89	24	cells	cell	NOUN
bjp-23565	89	25	respectively	respectively	ADV
bjp-23565	89	26	.	.	PUNCT
bjp-23565	90	1	drug	drug	NOUN
bjp-23565	90	2	-	-	PUNCT
bjp-23565	90	3	induced	induce	VERB
bjp-23565	90	4	cell	cell	NOUN
bjp-23565	90	5	growth	growth	NOUN
bjp-23565	90	6	inhibition	inhibition	NOUN
bjp-23565	90	7	was	be	AUX
bjp-23565	90	8	the	the	DET
bjp-23565	90	9	main	main	ADJ
bjp-23565	90	10	reason	reason	NOUN
bjp-23565	90	11	for	for	ADP
bjp-23565	90	12	the	the	DET
bjp-23565	90	13	changes	change	NOUN
bjp-23565	90	14	in	in	ADP
bjp-23565	90	15	the	the	DET
bjp-23565	90	16	expression	expression	NOUN
bjp-23565	90	17	of	of	ADP
bjp-23565	90	18	cell	cell	NOUN
bjp-23565	90	19	cycle	cycle	NOUN
bjp-23565	90	20	regulatory	regulatory	ADJ
bjp-23565	90	21	proteins	protein	NOUN
bjp-23565	90	22	.	.	PUNCT
bjp-23565	91	1	figure	figure	NOUN
bjp-23565	91	2	6	6	NUM
bjp-23565	91	3	indicates	indicate	VERB
bjp-23565	91	4	the	the	DET
bjp-23565	91	5	decreased	decrease	VERB
bjp-23565	91	6	levels	level	NOUN
bjp-23565	91	7	of	of	ADP
bjp-23565	91	8	various	various	ADJ
bjp-23565	91	9	cyclins	cyclin	NOUN
bjp-23565	91	10	upon	upon	SCONJ
bjp-23565	91	11	paclitaxel	paclitaxel	NOUN
bjp-23565	91	12	and	and	CCONJ
bjp-23565	91	13	trastuzumab	trastuzumab	NOUN
bjp-23565	91	14	treatment	treatment	NOUN
bjp-23565	91	15	since	since	SCONJ
bjp-23565	91	16	cyclins	cyclin	NOUN
bjp-23565	91	17	are	be	AUX
bjp-23565	91	18	most	most	ADV
bjp-23565	91	19	important	important	ADJ
bjp-23565	91	20	for	for	SCONJ
bjp-23565	91	21	the	the	DET
bjp-23565	91	22	cells	cell	NOUN
bjp-23565	91	23	to	to	PART
bjp-23565	91	24	go	go	VERB
bjp-23565	91	25	through	through	ADP
bjp-23565	91	26	various	various	ADJ
bjp-23565	91	27	stages	stage	NOUN
bjp-23565	91	28	of	of	ADP
bjp-23565	91	29	cell	cell	NOUN
bjp-23565	91	30	cycle	cycle	NOUN
bjp-23565	91	31	and	and	CCONJ
bjp-23565	91	32	alteration	alteration	NOUN
bjp-23565	91	33	in	in	ADP
bjp-23565	91	34	the	the	DET
bjp-23565	91	35	cyclin	cyclin	NOUN
bjp-23565	91	36	expression	expression	NOUN
bjp-23565	91	37	depicts	depict	VERB
bjp-23565	91	38	the	the	DET
bjp-23565	91	39	cell	cell	NOUN
bjp-23565	91	40	cycle	cycle	NOUN
bjp-23565	91	41	after	after	ADP
bjp-23565	91	42	the	the	DET
bjp-23565	91	43	drug	drug	NOUN
bjp-23565	91	44	treatment	treatment	NOUN
bjp-23565	91	45	.	.	PUNCT
bjp-23565	92	1	p21	p21	NOUN
bjp-23565	92	2	level	level	NOUN
bjp-23565	92	3	was	be	AUX
bjp-23565	92	4	found	find	VERB
bjp-23565	92	5	to	to	PART
bjp-23565	92	6	be	be	AUX
bjp-23565	92	7	markedly	markedly	ADV
bjp-23565	92	8	increased	increase	VERB
bjp-23565	92	9	in	in	ADP
bjp-23565	92	10	drug	drug	NOUN
bjp-23565	92	11	treated	treat	VERB
bjp-23565	92	12	t47d	t47d	DET
bjp-23565	92	13	and	and	CCONJ
bjp-23565	92	14	hs0578	hs0578	PROPN
bjp-23565	92	15	t	t	NOUN
bjp-23565	92	16	cells	cell	NOUN
bjp-23565	92	17	since	since	SCONJ
bjp-23565	92	18	it	it	PRON
bjp-23565	92	19	is	be	AUX
bjp-23565	92	20	an	an	DET
bjp-23565	92	21	inhibitor	inhibitor	NOUN
bjp-23565	92	22	to	to	PART
bjp-23565	92	23	potent	potent	VERB
bjp-23565	92	24	cyclin	cyclin	NOUN
bjp-23565	92	25	dependant	dependant	PROPN
bjp-23565	92	26	kinase	kinase	PROPN
bjp-23565	92	27	(	(	PUNCT
bjp-23565	92	28	cdk	cdk	PROPN
bjp-23565	92	29	)	)	PUNCT
bjp-23565	92	30	involved	involve	VERB
bjp-23565	92	31	in	in	ADP
bjp-23565	92	32	cyclin	cyclin	NOUN
bjp-23565	92	33	-	-	PUNCT
bjp-23565	92	34	cdk	cdk	NOUN
bjp-23565	92	35	binding	bind	VERB
bjp-23565	92	36	and	and	CCONJ
bjp-23565	92	37	thereby	thereby	ADV
bjp-23565	92	38	preventing	prevent	VERB
bjp-23565	92	39	its	its	PRON
bjp-23565	92	40	catalytic	catalytic	ADJ
bjp-23565	92	41	activity	activity	NOUN
bjp-23565	92	42	and	and	CCONJ
bjp-23565	92	43	paving	pave	VERB
bjp-23565	92	44	the	the	DET
bjp-23565	92	45	way	way	NOUN
bjp-23565	92	46	for	for	ADP
bjp-23565	92	47	cell	cell	NOUN
bjp-23565	92	48	cycle	cycle	NOUN
bjp-23565	92	49	arrest	arrest	NOUN
bjp-23565	92	50	.	.	PUNCT
bjp-23565	93	1	discussion	discussion	NOUN
bjp-23565	93	2	in	in	ADP
bjp-23565	93	3	this	this	DET
bjp-23565	93	4	study	study	NOUN
bjp-23565	93	5	,	,	PUNCT
bjp-23565	93	6	we	we	PRON
bjp-23565	93	7	report	report	VERB
bjp-23565	93	8	about	about	ADP
bjp-23565	93	9	the	the	DET
bjp-23565	93	10	synergistic	synergistic	ADJ
bjp-23565	93	11	effect	effect	NOUN
bjp-23565	93	12	of	of	ADP
bjp-23565	93	13	paclitaxel	paclitaxel	NOUN
bjp-23565	93	14	and	and	CCONJ
bjp-23565	93	15	trastuzumab	trastuzumab	NOUN
bjp-23565	93	16	and	and	CCONJ
bjp-23565	93	17	their	their	PRON
bjp-23565	93	18	action	action	NOUN
bjp-23565	93	19	on	on	ADP
bjp-23565	93	20	the	the	DET
bjp-23565	93	21	survival	survival	NOUN
bjp-23565	93	22	of	of	ADP
bjp-23565	93	23	er+	er+	NOUN
bjp-23565	93	24	and	and	CCONJ
bjp-23565	93	25	erbreast	erbreast	NOUN
bjp-23565	93	26	cancer	cancer	NOUN
bjp-23565	93	27	cell	cell	NOUN
bjp-23565	93	28	lines	line	NOUN
bjp-23565	93	29	.	.	PUNCT
bjp-23565	94	1	this	this	PRON
bjp-23565	94	2	was	be	AUX
bjp-23565	94	3	based	base	VERB
bjp-23565	94	4	on	on	ADP
bjp-23565	94	5	the	the	DET
bjp-23565	94	6	igf-1	igf-1	NOUN
bjp-23565	94	7	signaling	signal	VERB
bjp-23565	94	8	and	and	CCONJ
bjp-23565	94	9	their	their	PRON
bjp-23565	94	10	role	role	NOUN
bjp-23565	94	11	in	in	ADP
bjp-23565	94	12	breast	breast	NOUN
bjp-23565	94	13	cancer	cancer	NOUN
bjp-23565	94	14	has	have	AUX
bjp-23565	94	15	been	be	AUX
bjp-23565	94	16	supported	support	VERB
bjp-23565	94	17	by	by	ADP
bjp-23565	94	18	several	several	ADJ
bjp-23565	94	19	clinical	clinical	ADJ
bjp-23565	94	20	studies	study	NOUN
bjp-23565	94	21	(	(	PUNCT
bjp-23565	94	22	figueroa	figueroa	PROPN
bjp-23565	94	23	and	and	CCONJ
bjp-23565	94	24	yee	yee	PROPN
bjp-23565	94	25	,	,	PUNCT
bjp-23565	94	26	1992	1992	NUM
bjp-23565	94	27	;	;	PUNCT
bjp-23565	94	28	papa	papa	VERB
bjp-23565	94	29	et	et	PROPN
bjp-23565	94	30	al	al	PROPN
bjp-23565	94	31	.	.	PROPN
bjp-23565	94	32	,	,	PUNCT
bjp-23565	94	33	1993	1993	NUM
bjp-23565	94	34	;	;	PUNCT
bjp-23565	94	35	resnik	resnik	PROPN
bjp-23565	94	36	et	et	PROPN
bjp-23565	94	37	al	al	PROPN
bjp-23565	94	38	.	.	PROPN
bjp-23565	94	39	,	,	PUNCT
bjp-23565	94	40	1998	1998	NUM
bjp-23565	94	41	;	;	PUNCT
bjp-23565	94	42	li	li	PROPN
bjp-23565	94	43	et	et	PROPN
bjp-23565	94	44	al	al	PROPN
bjp-23565	94	45	.	.	PROPN
bjp-23565	94	46	,	,	PUNCT
bjp-23565	94	47	2001	2001	NUM
bjp-23565	94	48	;	;	PUNCT
bjp-23565	94	49	michels	michel	NOUN
bjp-23565	94	50	and	and	CCONJ
bjp-23565	94	51	willet	willet	PROPN
bjp-23565	94	52	,	,	PUNCT
bjp-23565	94	53	2004	2004	NUM
bjp-23565	94	54	;	;	PUNCT
bjp-23565	94	55	lu	lu	PROPN
bjp-23565	94	56	et	et	PROPN
bjp-23565	94	57	al	al	PROPN
bjp-23565	94	58	.	.	PROPN
bjp-23565	94	59	,	,	PUNCT
bjp-23565	94	60	2001	2001	NUM
bjp-23565	94	61	)	)	PUNCT
bjp-23565	94	62	.	.	PUNCT
bjp-23565	95	1	targeting	target	VERB
bjp-23565	95	2	the	the	DET
bjp-23565	95	3	pathway	pathway	NOUN
bjp-23565	95	4	of	of	ADP
bjp-23565	95	5	igf-1r	igf-1r	PROPN
bjp-23565	95	6	can	can	AUX
bjp-23565	95	7	be	be	AUX
bjp-23565	95	8	promising	promise	VERB
bjp-23565	95	9	in	in	ADP
bjp-23565	95	10	developing	develop	VERB
bjp-23565	95	11	new	new	ADJ
bjp-23565	95	12	therapies	therapy	NOUN
bjp-23565	95	13	for	for	ADP
bjp-23565	95	14	breast	breast	NOUN
bjp-23565	95	15	cancer	cancer	NOUN
bjp-23565	95	16	treatment	treatment	NOUN
bjp-23565	95	17	.	.	PUNCT
bjp-23565	96	1	we	we	PRON
bjp-23565	96	2	observed	observe	VERB
bjp-23565	96	3	that	that	SCONJ
bjp-23565	96	4	the	the	DET
bjp-23565	96	5	combined	combined	ADJ
bjp-23565	96	6	paclitaxel	paclitaxel	NOUN
bjp-23565	96	7	and	and	CCONJ
bjp-23565	96	8	trastuzumab	trastuzumab	NOUN
bjp-23565	96	9	distinctly	distinctly	ADV
bjp-23565	96	10	prevented	prevent	VERB
bjp-23565	96	11	proliferation	proliferation	NOUN
bjp-23565	96	12	of	of	ADP
bjp-23565	96	13	cells	cell	NOUN
bjp-23565	96	14	as	as	ADP
bjp-23565	96	15	evident	evident	ADJ
bjp-23565	96	16	from	from	ADP
bjp-23565	96	17	their	their	PRON
bjp-23565	96	18	ic50	ic50	PROPN
bjp-23565	96	19	values	value	NOUN
bjp-23565	96	20	.	.	PUNCT
bjp-23565	97	1	after	after	ADP
bjp-23565	97	2	24	24	NUM
bjp-23565	97	3	and	and	CCONJ
bjp-23565	97	4	48	48	NUM
bjp-23565	97	5	hours	hour	NOUN
bjp-23565	97	6	,	,	PUNCT
bjp-23565	97	7	ic50	ic50	PROPN
bjp-23565	97	8	values	value	NOUN
bjp-23565	97	9	were	be	AUX
bjp-23565	97	10	6	6	NUM
bjp-23565	97	11	and	and	CCONJ
bjp-23565	97	12	3.7	3.7	NUM
bjp-23565	97	13	mm	mm	NOUN
bjp-23565	97	14	for	for	ADP
bjp-23565	97	15	t47d	t47d	DET
bjp-23565	97	16	cells	cell	NOUN
bjp-23565	97	17	and	and	CCONJ
bjp-23565	97	18	7	7	NUM
bjp-23565	97	19	and	and	CCONJ
bjp-23565	97	20	5.2	5.2	NUM
bjp-23565	97	21	mm	mm	NOUN
bjp-23565	97	22	for	for	ADP
bjp-23565	97	23	hs0578	hs0578	PROPN
bjp-23565	97	24	t	t	NOUN
bjp-23565	97	25	cells	cell	NOUN
bjp-23565	97	26	respectively	respectively	ADV
bjp-23565	97	27	.	.	PUNCT
bjp-23565	98	1	igfbp-3	igfbp-3	PRON
bjp-23565	98	2	is	be	AUX
bjp-23565	98	3	a	a	DET
bjp-23565	98	4	major	major	ADJ
bjp-23565	98	5	igf	igf	NOUN
bjp-23565	98	6	binding	bind	VERB
bjp-23565	98	7	protein	protein	NOUN
bjp-23565	98	8	showed	show	VERB
bjp-23565	98	9	competitive	competitive	ADJ
bjp-23565	98	10	inhibition	inhibition	NOUN
bjp-23565	98	11	towards	towards	ADP
bjp-23565	98	12	igf	igf	PROPN
bjp-23565	98	13	action	action	NOUN
bjp-23565	98	14	.	.	PUNCT
bjp-23565	99	1	the	the	DET
bjp-23565	99	2	igf	igf	PROPN
bjp-23565	99	3	inhibition	inhibition	NOUN
bjp-23565	99	4	activates	activate	VERB
bjp-23565	99	5	caspases	caspase	NOUN
bjp-23565	99	6	involved	involve	VERB
bjp-23565	99	7	in	in	ADP
bjp-23565	99	8	cell	cell	NOUN
bjp-23565	99	9	death	death	NOUN
bjp-23565	99	10	and	and	CCONJ
bjp-23565	99	11	causes	cause	VERB
bjp-23565	99	12	apoptosis	apoptosis	NOUN
bjp-23565	99	13	and	and	CCONJ
bjp-23565	99	14	prevents	prevent	VERB
bjp-23565	99	15	proliferation	proliferation	NOUN
bjp-23565	99	16	independent	independent	ADJ
bjp-23565	99	17	of	of	ADP
bjp-23565	99	18	igf	igf	PROPN
bjp-23565	99	19	(	(	PUNCT
bjp-23565	99	20	kim	kim	PROPN
bjp-23565	99	21	et	et	PROPN
bjp-23565	99	22	al	al	PROPN
bjp-23565	99	23	.	.	PROPN
bjp-23565	99	24	,	,	PUNCT
bjp-23565	99	25	2004	2004	NUM
bjp-23565	99	26	)	)	PUNCT
bjp-23565	99	27	.	.	PUNCT
bjp-23565	100	1	this	this	DET
bjp-23565	100	2	study	study	NOUN
bjp-23565	100	3	indicates	indicate	VERB
bjp-23565	100	4	that	that	SCONJ
bjp-23565	100	5	reduced	reduced	ADJ
bjp-23565	100	6	expression	expression	NOUN
bjp-23565	100	7	of	of	ADP
bjp-23565	100	8	igf-1rb	igf-1rb	NOUN
bjp-23565	100	9	and	and	CCONJ
bjp-23565	100	10	higher	high	ADJ
bjp-23565	100	11	expression	expression	NOUN
bjp-23565	100	12	of	of	ADP
bjp-23565	100	13	igfbp-3	igfbp-3	NUM
bjp-23565	100	14	drug	drug	NOUN
bjp-23565	100	15	treated	treat	VERB
bjp-23565	100	16	cells	cell	NOUN
bjp-23565	100	17	.	.	PUNCT
bjp-23565	101	1	the	the	DET
bjp-23565	101	2	tyrosine	tyrosine	PROPN
bjp-23565	101	3	kinase	kinase	PROPN
bjp-23565	101	4	domain	domain	NOUN
bjp-23565	101	5	residues	residue	NOUN
bjp-23565	101	6	in	in	ADP
bjp-23565	101	7	the	the	DET
bjp-23565	101	8	β	β	NOUN
bjp-23565	101	9	-	-	NOUN
bjp-23565	101	10	subunit	subunit	NOUN
bjp-23565	101	11	are	be	AUX
bjp-23565	101	12	autophosphofigure	autophosphofigure	PRON
bjp-23565	101	13	2	2	NUM
bjp-23565	101	14	:	:	PUNCT
bjp-23565	101	15	effect	effect	NOUN
bjp-23565	101	16	of	of	ADP
bjp-23565	101	17	paclitaxel	paclitaxel	PROPN
bjp-23565	101	18	and	and	CCONJ
bjp-23565	101	19	trastuzumab	trastuzumab	NOUN
bjp-23565	101	20	treatment	treatment	NOUN
bjp-23565	101	21	on	on	ADP
bjp-23565	101	22	various	various	ADJ
bjp-23565	101	23	protein	protein	NOUN
bjp-23565	101	24	expression	expression	NOUN
bjp-23565	101	25	in	in	ADP
bjp-23565	101	26	mapk	mapk	NOUN
bjp-23565	101	27	pathway	pathway	NOUN
bjp-23565	101	28	in	in	ADP
bjp-23565	101	29	t47d	t47d	PRON
bjp-23565	101	30	and	and	CCONJ
bjp-23565	101	31	hs0578	hs0578	PROPN
bjp-23565	101	32	t	t	PROPN
bjp-23565	101	33	cells	cell	NOUN
bjp-23565	101	34	802	802	NUM
bjp-23565	101	35	bangladesh	bangladesh	PROPN
bjp-23565	101	36	j	j	PROPN
bjp-23565	101	37	pharmacol	pharmacol	PROPN
bjp-23565	101	38	2015	2015	NUM
bjp-23565	101	39	;	;	PUNCT
bjp-23565	101	40	10	10	NUM
bjp-23565	101	41	:	:	PUNCT
bjp-23565	101	42	799	799	NUM
bjp-23565	101	43	-	-	SYM
bjp-23565	101	44	806	806	NUM
bjp-23565	101	45	rylated	rylate	VERB
bjp-23565	101	46	during	during	ADP
bjp-23565	101	47	the	the	DET
bjp-23565	101	48	ligand	ligand	ADJ
bjp-23565	101	49	interaction	interaction	NOUN
bjp-23565	101	50	with	with	ADP
bjp-23565	101	51	igf-1r	igf-1r	PROPN
bjp-23565	101	52	.	.	PUNCT
bjp-23565	102	1	other	other	ADJ
bjp-23565	102	2	phosphorylation	phosphorylation	NOUN
bjp-23565	102	3	sites	site	NOUN
bjp-23565	102	4	function	function	VERB
bjp-23565	102	5	as	as	ADP
bjp-23565	102	6	a	a	DET
bjp-23565	102	7	docking	docking	NOUN
bjp-23565	102	8	site	site	NOUN
bjp-23565	102	9	for	for	ADP
bjp-23565	102	10	irs	irs	PROPN
bjp-23565	102	11	facilitating	facilitate	VERB
bjp-23565	102	12	through	through	ADP
bjp-23565	102	13	the	the	DET
bjp-23565	102	14	pi3k	pi3k	NOUN
bjp-23565	102	15	subunit	subunit	NOUN
bjp-23565	102	16	regulation	regulation	NOUN
bjp-23565	102	17	.	.	PUNCT
bjp-23565	103	1	the	the	DET
bjp-23565	103	2	receptor	receptor	NOUN
bjp-23565	103	3	can	can	AUX
bjp-23565	103	4	also	also	ADV
bjp-23565	103	5	activate	activate	VERB
bjp-23565	103	6	the	the	DET
bjp-23565	103	7	mapk	mapk	NOUN
bjp-23565	103	8	pathway	pathway	NOUN
bjp-23565	103	9	by	by	ADP
bjp-23565	103	10	recruiting	recruit	VERB
bjp-23565	103	11	shc	shc	PROPN
bjp-23565	103	12	.	.	PUNCT
bjp-23565	104	1	the	the	DET
bjp-23565	104	2	expression	expression	NOUN
bjp-23565	104	3	of	of	ADP
bjp-23565	104	4	raf	raf	PROPN
bjp-23565	104	5	,	,	PUNCT
bjp-23565	104	6	irs-2	irs-2	ADV
bjp-23565	104	7	,	,	PUNCT
bjp-23565	104	8	pi3k	pi3k	PROPN
bjp-23565	104	9	and	and	CCONJ
bjp-23565	104	10	ras	ras	PROPN
bjp-23565	104	11	proteins	protein	NOUN
bjp-23565	104	12	were	be	AUX
bjp-23565	104	13	reduced	reduce	VERB
bjp-23565	104	14	drug	drug	NOUN
bjp-23565	104	15	treated	treat	VERB
bjp-23565	104	16	cells	cell	NOUN
bjp-23565	104	17	.	.	PUNCT
bjp-23565	105	1	pten	pten	NOUN
bjp-23565	105	2	is	be	AUX
bjp-23565	105	3	a	a	DET
bjp-23565	105	4	tumor	tumor	NOUN
bjp-23565	105	5	suppressor	suppressor	NOUN
bjp-23565	105	6	and	and	CCONJ
bjp-23565	105	7	most	most	ADV
bjp-23565	105	8	commonly	commonly	ADV
bjp-23565	105	9	mutated	mutate	VERB
bjp-23565	105	10	protein	protein	NOUN
bjp-23565	105	11	.	.	PUNCT
bjp-23565	106	1	the	the	DET
bjp-23565	106	2	combination	combination	NOUN
bjp-23565	106	3	of	of	ADP
bjp-23565	106	4	paclitaxel	paclitaxel	PROPN
bjp-23565	106	5	and	and	CCONJ
bjp-23565	106	6	trastuzumab	trastuzumab	NOUN
bjp-23565	106	7	figure	figure	NOUN
bjp-23565	106	8	3	3	NUM
bjp-23565	106	9	:	:	PUNCT
bjp-23565	106	10	pakt	pakt	NOUN
bjp-23565	106	11	protein	protein	NOUN
bjp-23565	106	12	expression	expression	NOUN
bjp-23565	106	13	in	in	ADP
bjp-23565	106	14	t47d	t47d	PRON
bjp-23565	106	15	and	and	CCONJ
bjp-23565	106	16	hs0578	hs0578	PROPN
bjp-23565	106	17	t	t	NOUN
bjp-23565	106	18	cells	cell	NOUN
bjp-23565	106	19	treated	treat	VERB
bjp-23565	106	20	with	with	ADP
bjp-23565	106	21	paclitaxel	paclitaxel	NOUN
bjp-23565	106	22	and	and	CCONJ
bjp-23565	106	23	trastuzumab	trastuzumab	NOUN
bjp-23565	106	24	and	and	CCONJ
bjp-23565	106	25	induced	induce	VERB
bjp-23565	106	26	by	by	ADP
bjp-23565	106	27	igf-1	igf-1	ADV
bjp-23565	106	28	and	and	CCONJ
bjp-23565	106	29	inhibited	inhibit	VERB
bjp-23565	106	30	by	by	ADP
bjp-23565	106	31	ly294002	ly294002	ADJ
bjp-23565	106	32	figure	figure	NOUN
bjp-23565	106	33	4	4	NUM
bjp-23565	106	34	:	:	PUNCT
bjp-23565	106	35	effect	effect	NOUN
bjp-23565	106	36	of	of	ADP
bjp-23565	106	37	paclitaxel	paclitaxel	NOUN
bjp-23565	106	38	and	and	CCONJ
bjp-23565	106	39	trastuzumab	trastuzumab	NOUN
bjp-23565	106	40	in	in	ADP
bjp-23565	106	41	expression	expression	NOUN
bjp-23565	106	42	of	of	ADP
bjp-23565	106	43	proteins	protein	NOUN
bjp-23565	106	44	c	c	NOUN
bjp-23565	106	45	-	-	PUNCT
bjp-23565	106	46	myc	myc	NOUN
bjp-23565	106	47	and	and	CCONJ
bjp-23565	106	48	b	b	X
bjp-23565	106	49	-	-	PUNCT
bjp-23565	106	50	catenin	catenin	NOUN
bjp-23565	106	51	in	in	ADP
bjp-23565	106	52	igf-1	igf-1	ADV
bjp-23565	106	53	mediated	mediate	VERB
bjp-23565	106	54	cell	cell	NOUN
bjp-23565	106	55	proliferation	proliferation	NOUN
bjp-23565	106	56	bangladesh	bangladesh	PROPN
bjp-23565	106	57	j	j	PROPN
bjp-23565	106	58	pharmacol	pharmacol	PROPN
bjp-23565	106	59	2015	2015	NUM
bjp-23565	106	60	;	;	PUNCT
bjp-23565	106	61	10	10	NUM
bjp-23565	106	62	:	:	PUNCT
bjp-23565	106	63	799	799	NUM
bjp-23565	106	64	-	-	SYM
bjp-23565	106	65	806	806	NUM
bjp-23565	106	66	803	803	NUM
bjp-23565	106	67	showed	show	VERB
bjp-23565	106	68	pten	pten	NOUN
bjp-23565	106	69	expression	expression	NOUN
bjp-23565	106	70	in	in	ADP
bjp-23565	106	71	both	both	DET
bjp-23565	106	72	cell	cell	NOUN
bjp-23565	106	73	lines	line	NOUN
bjp-23565	106	74	were	be	AUX
bjp-23565	106	75	found	find	VERB
bjp-23565	106	76	to	to	PART
bjp-23565	106	77	be	be	AUX
bjp-23565	106	78	increased	increase	VERB
bjp-23565	106	79	.	.	PUNCT
bjp-23565	107	1	we	we	PRON
bjp-23565	107	2	studied	study	VERB
bjp-23565	107	3	the	the	DET
bjp-23565	107	4	role	role	NOUN
bjp-23565	107	5	of	of	ADP
bjp-23565	107	6	akt	akt	PROPN
bjp-23565	107	7	in	in	ADP
bjp-23565	107	8	cell	cell	NOUN
bjp-23565	107	9	growth	growth	NOUN
bjp-23565	107	10	and	and	CCONJ
bjp-23565	107	11	cell	cell	NOUN
bjp-23565	107	12	deaths	death	NOUN
bjp-23565	107	13	in	in	ADP
bjp-23565	107	14	er+	er+	NOUN
bjp-23565	107	15	and	and	CCONJ
bjp-23565	107	16	erbreast	erbreast	NOUN
bjp-23565	107	17	cancer	cancer	NOUN
bjp-23565	107	18	cell	cell	NOUN
bjp-23565	107	19	lines	line	NOUN
bjp-23565	107	20	by	by	ADP
bjp-23565	107	21	using	use	VERB
bjp-23565	107	22	pi3k	pi3k	PROPN
bjp-23565	107	23	inhibitor	inhibitor	NOUN
bjp-23565	107	24	,	,	PUNCT
bjp-23565	107	25	ly294002	ly294002	PROPN
bjp-23565	107	26	.	.	PUNCT
bjp-23565	108	1	the	the	DET
bjp-23565	108	2	mechanism	mechanism	NOUN
bjp-23565	108	3	of	of	ADP
bjp-23565	108	4	akt	akt	PROPN
bjp-23565	108	5	inhibition	inhibition	NOUN
bjp-23565	108	6	by	by	ADP
bjp-23565	108	7	drug	drug	NOUN
bjp-23565	108	8	treatment	treatment	NOUN
bjp-23565	108	9	was	be	AUX
bjp-23565	108	10	studied	study	VERB
bjp-23565	108	11	by	by	ADP
bjp-23565	108	12	first	first	ADV
bjp-23565	108	13	inducing	induce	VERB
bjp-23565	108	14	the	the	DET
bjp-23565	108	15	proliferation	proliferation	NOUN
bjp-23565	108	16	of	of	ADP
bjp-23565	108	17	both	both	CCONJ
bjp-23565	108	18	the	the	DET
bjp-23565	108	19	cells	cell	NOUN
bjp-23565	108	20	lines	line	NOUN
bjp-23565	108	21	by	by	ADP
bjp-23565	108	22	igf-1	igf-1	ADV
bjp-23565	108	23	and	and	CCONJ
bjp-23565	108	24	then	then	ADV
bjp-23565	108	25	blocked	block	VERB
bjp-23565	108	26	by	by	ADP
bjp-23565	108	27	ly294002	ly294002	PROPN
bjp-23565	108	28	.	.	PUNCT
bjp-23565	109	1	the	the	DET
bjp-23565	109	2	experimental	experimental	ADJ
bjp-23565	109	3	results	result	NOUN
bjp-23565	109	4	showed	show	VERB
bjp-23565	109	5	that	that	SCONJ
bjp-23565	109	6	both	both	CCONJ
bjp-23565	109	7	the	the	DET
bjp-23565	109	8	drugs	drug	NOUN
bjp-23565	109	9	and	and	CCONJ
bjp-23565	109	10	the	the	DET
bjp-23565	109	11	inhibitor	inhibitor	NOUN
bjp-23565	109	12	reduced	reduce	VERB
bjp-23565	109	13	the	the	DET
bjp-23565	109	14	expression	expression	NOUN
bjp-23565	109	15	of	of	ADP
bjp-23565	109	16	pakt	pakt	NOUN
bjp-23565	109	17	in	in	ADP
bjp-23565	109	18	breast	breast	NOUN
bjp-23565	109	19	cancer	cancer	NOUN
bjp-23565	109	20	lines	line	NOUN
bjp-23565	109	21	induced	induce	VERB
bjp-23565	109	22	by	by	ADP
bjp-23565	109	23	igf-1	igf-1	NOUN
bjp-23565	109	24	.	.	PUNCT
bjp-23565	110	1	this	this	DET
bjp-23565	110	2	result	result	NOUN
bjp-23565	110	3	highlighted	highlight	VERB
bjp-23565	110	4	the	the	DET
bjp-23565	110	5	need	need	NOUN
bjp-23565	110	6	of	of	ADP
bjp-23565	110	7	pi3k	pi3k	PROPN
bjp-23565	110	8	/	/	SYM
bjp-23565	110	9	akt	akt	PROPN
bjp-23565	110	10	pathway	pathway	NOUN
bjp-23565	110	11	in	in	ADP
bjp-23565	110	12	cell	cell	NOUN
bjp-23565	110	13	growth	growth	NOUN
bjp-23565	110	14	.	.	PUNCT
bjp-23565	111	1	in	in	ADP
bjp-23565	111	2	addition	addition	NOUN
bjp-23565	111	3	the	the	DET
bjp-23565	111	4	down	down	ADJ
bjp-23565	111	5	regulation	regulation	NOUN
bjp-23565	111	6	of	of	ADP
bjp-23565	111	7	c	c	NOUN
bjp-23565	111	8	-	-	PUNCT
bjp-23565	111	9	myc	myc	NOUN
bjp-23565	111	10	and	and	CCONJ
bjp-23565	111	11	β	β	NOUN
bjp-23565	111	12	-	-	ADJ
bjp-23565	111	13	catenin	catenin	ADJ
bjp-23565	111	14	accumulation	accumulation	NOUN
bjp-23565	111	15	was	be	AUX
bjp-23565	111	16	also	also	ADV
bjp-23565	111	17	found	find	VERB
bjp-23565	111	18	in	in	ADP
bjp-23565	111	19	the	the	DET
bjp-23565	111	20	cells	cell	NOUN
bjp-23565	111	21	treated	treat	VERB
bjp-23565	111	22	with	with	ADP
bjp-23565	111	23	drug	drug	NOUN
bjp-23565	111	24	.	.	PUNCT
bjp-23565	112	1	the	the	DET
bjp-23565	112	2	combination	combination	NOUN
bjp-23565	112	3	of	of	ADP
bjp-23565	112	4	paclitaxel	paclitaxel	PROPN
bjp-23565	112	5	and	and	CCONJ
bjp-23565	112	6	trastuzumab	trastuzumab	NOUN
bjp-23565	112	7	regulates	regulate	VERB
bjp-23565	112	8	the	the	DET
bjp-23565	112	9	mapk	mapk	NOUN
bjp-23565	112	10	pathway	pathway	NOUN
bjp-23565	112	11	as	as	ADP
bjp-23565	112	12	evident	evident	ADJ
bjp-23565	112	13	by	by	ADP
bjp-23565	112	14	the	the	DET
bjp-23565	112	15	altered	altered	ADJ
bjp-23565	112	16	protein	protein	NOUN
bjp-23565	112	17	expression	expression	NOUN
bjp-23565	112	18	of	of	ADP
bjp-23565	112	19	mek	mek	PROPN
bjp-23565	112	20	,	,	PUNCT
bjp-23565	112	21	erk	erk	PROPN
bjp-23565	112	22	1	1	NUM
bjp-23565	112	23	and	and	CCONJ
bjp-23565	112	24	2	2	NUM
bjp-23565	112	25	and	and	CCONJ
bjp-23565	112	26	p38	p38	NOUN
bjp-23565	112	27	in	in	ADP
bjp-23565	112	28	both	both	CCONJ
bjp-23565	112	29	t47d	t47d	PRON
bjp-23565	112	30	and	and	CCONJ
bjp-23565	112	31	hs0578	hs0578	PROPN
bjp-23565	112	32	t	t	NOUN
bjp-23565	112	33	cells	cell	NOUN
bjp-23565	112	34	.	.	PUNCT
bjp-23565	113	1	this	this	PRON
bjp-23565	113	2	was	be	AUX
bjp-23565	113	3	corroborated	corroborate	VERB
bjp-23565	113	4	by	by	ADP
bjp-23565	113	5	i	i	PROPN
bjp-23565	113	6	)	)	PUNCT
bjp-23565	113	7	down	down	ADP
bjp-23565	113	8	-	-	PUNCT
bjp-23565	113	9	regulation	regulation	NOUN
bjp-23565	113	10	of	of	ADP
bjp-23565	113	11	mek	mek	PROPN
bjp-23565	113	12	and	and	CCONJ
bjp-23565	113	13	perk	perk	NOUN
bjp-23565	113	14	1	1	NUM
bjp-23565	113	15	,	,	PUNCT
bjp-23565	113	16	2	2	NUM
bjp-23565	113	17	and	and	CCONJ
bjp-23565	113	18	upregulation	upregulation	NOUN
bjp-23565	113	19	of	of	ADP
bjp-23565	113	20	p38	p38	NOUN
bjp-23565	113	21	in	in	ADP
bjp-23565	113	22	both	both	CCONJ
bjp-23565	113	23	the	the	DET
bjp-23565	113	24	cell	cell	NOUN
bjp-23565	113	25	lines	line	NOUN
bjp-23565	113	26	upon	upon	SCONJ
bjp-23565	113	27	drug	drug	NOUN
bjp-23565	113	28	treatment	treatment	NOUN
bjp-23565	113	29	;	;	PUNCT
bjp-23565	113	30	ii	ii	X
bjp-23565	113	31	)	)	PUNCT
bjp-23565	113	32	decrease	decrease	NOUN
bjp-23565	113	33	in	in	ADP
bjp-23565	113	34	erk	erk	PROPN
bjp-23565	113	35	1	1	NUM
bjp-23565	113	36	,	,	PUNCT
bjp-23565	113	37	2	2	NUM
bjp-23565	113	38	activation	activation	NOUN
bjp-23565	113	39	in	in	ADP
bjp-23565	113	40	cells	cell	NOUN
bjp-23565	113	41	figure	figure	VERB
bjp-23565	113	42	5	5	NUM
bjp-23565	113	43	:	:	PUNCT
bjp-23565	113	44	cell	cell	NOUN
bjp-23565	113	45	cycle	cycle	NOUN
bjp-23565	113	46	analysis	analysis	NOUN
bjp-23565	113	47	of	of	ADP
bjp-23565	113	48	paclitaxel	paclitaxel	NOUN
bjp-23565	113	49	and	and	CCONJ
bjp-23565	113	50	trastuzumab	trastuzumab	NOUN
bjp-23565	113	51	treated	treat	VERB
bjp-23565	113	52	t47d	t47d	PRON
bjp-23565	113	53	and	and	CCONJ
bjp-23565	113	54	hs0578	hs0578	PROPN
bjp-23565	113	55	t	t	NOUN
bjp-23565	113	56	cells	cell	NOUN
bjp-23565	113	57	.	.	PUNCT
bjp-23565	114	1	total	total	ADJ
bjp-23565	114	2	cell	cell	NOUN
bjp-23565	114	3	population	population	NOUN
bjp-23565	114	4	was	be	AUX
bjp-23565	114	5	taken	take	VERB
bjp-23565	114	6	in	in	ADP
bjp-23565	114	7	to	to	ADP
bjp-23565	114	8	account	account	NOUN
bjp-23565	114	9	to	to	PART
bjp-23565	114	10	calculate	calculate	VERB
bjp-23565	114	11	number	number	NOUN
bjp-23565	114	12	of	of	ADP
bjp-23565	114	13	cells	cell	NOUN
bjp-23565	114	14	in	in	ADP
bjp-23565	114	15	each	each	DET
bjp-23565	114	16	cell	cell	NOUN
bjp-23565	114	17	cycle	cycle	NOUN
bjp-23565	114	18	phase	phase	NOUN
bjp-23565	114	19	figure	figure	NOUN
bjp-23565	114	20	6	6	NUM
bjp-23565	114	21	:	:	PUNCT
bjp-23565	114	22	the	the	DET
bjp-23565	114	23	expression	expression	NOUN
bjp-23565	114	24	of	of	ADP
bjp-23565	114	25	cyclins	cyclin	NOUN
bjp-23565	114	26	in	in	ADP
bjp-23565	114	27	paclitaxel	paclitaxel	PROPN
bjp-23565	114	28	and	and	CCONJ
bjp-23565	114	29	trastuzumab	trastuzumab	NOUN
bjp-23565	114	30	treated	treat	VERB
bjp-23565	114	31	breast	breast	NOUN
bjp-23565	114	32	cancer	cancer	NOUN
bjp-23565	114	33	cell	cell	NOUN
bjp-23565	114	34	lines	line	NOUN
bjp-23565	114	35	analyzed	analyze	VERB
bjp-23565	114	36	by	by	ADP
bjp-23565	114	37	immunoblot	immunoblot	NOUN
bjp-23565	114	38	804	804	NUM
bjp-23565	114	39	bangladesh	bangladesh	PROPN
bjp-23565	114	40	j	j	PROPN
bjp-23565	114	41	pharmacol	pharmacol	PROPN
bjp-23565	114	42	2015	2015	NUM
bjp-23565	114	43	;	;	PUNCT
bjp-23565	114	44	10	10	NUM
bjp-23565	114	45	:	:	PUNCT
bjp-23565	114	46	799	799	NUM
bjp-23565	114	47	-	-	SYM
bjp-23565	114	48	806	806	NUM
bjp-23565	114	49	treated	treat	VERB
bjp-23565	114	50	with	with	ADP
bjp-23565	114	51	paclitaxel	paclitaxel	PROPN
bjp-23565	114	52	and	and	CCONJ
bjp-23565	114	53	trastuzumab	trastuzumab	NOUN
bjp-23565	114	54	;	;	PUNCT
bjp-23565	114	55	iii	iii	X
bjp-23565	114	56	)	)	PUNCT
bjp-23565	114	57	increase	increase	NOUN
bjp-23565	114	58	in	in	ADP
bjp-23565	114	59	g0	g0	PROPN
bjp-23565	114	60	/	/	SYM
bjp-23565	114	61	g1	g1	PROPN
bjp-23565	114	62	population	population	NOUN
bjp-23565	114	63	in	in	ADP
bjp-23565	114	64	t47d	t47d	DET
bjp-23565	114	65	cells	cell	NOUN
bjp-23565	114	66	and	and	CCONJ
bjp-23565	114	67	noticeable	noticeable	ADJ
bjp-23565	114	68	changes	change	NOUN
bjp-23565	114	69	in	in	ADP
bjp-23565	114	70	hs0578	hs0578	PROPN
bjp-23565	114	71	t	t	NOUN
bjp-23565	114	72	cells	cell	NOUN
bjp-23565	114	73	(	(	PUNCT
bjp-23565	114	74	based	base	VERB
bjp-23565	114	75	on	on	ADP
bjp-23565	114	76	the	the	DET
bjp-23565	114	77	accumulation	accumulation	NOUN
bjp-23565	114	78	,	,	PUNCT
bjp-23565	114	79	apoptotic	apoptotic	ADJ
bjp-23565	114	80	cells	cell	NOUN
bjp-23565	114	81	were	be	AUX
bjp-23565	114	82	observed	observe	VERB
bjp-23565	114	83	)	)	PUNCT
bjp-23565	114	84	;	;	PUNCT
bjp-23565	114	85	iv	iv	X
bjp-23565	114	86	)	)	PUNCT
bjp-23565	114	87	decreased	decrease	VERB
bjp-23565	114	88	cyclin	cyclin	NOUN
bjp-23565	114	89	levels	level	NOUN
bjp-23565	114	90	upon	upon	SCONJ
bjp-23565	114	91	drug	drug	NOUN
bjp-23565	114	92	treatment	treatment	NOUN
bjp-23565	114	93	;	;	PUNCT
bjp-23565	114	94	(	(	PUNCT
bjp-23565	114	95	v	v	NOUN
bjp-23565	114	96	)	)	PUNCT
bjp-23565	114	97	increase	increase	NOUN
bjp-23565	114	98	in	in	ADP
bjp-23565	114	99	p21	p21	NOUN
bjp-23565	114	100	level	level	NOUN
bjp-23565	114	101	upon	upon	SCONJ
bjp-23565	114	102	paclitaxel	paclitaxel	NOUN
bjp-23565	114	103	and	and	CCONJ
bjp-23565	114	104	trastuzumab	trastuzumab	NOUN
bjp-23565	114	105	treatment	treatment	NOUN
bjp-23565	114	106	;	;	PUNCT
bjp-23565	114	107	vi	vi	X
bjp-23565	114	108	)	)	PUNCT
bjp-23565	114	109	reduced	reduce	VERB
bjp-23565	114	110	pcna	pcna	NOUN
bjp-23565	114	111	expression	expression	NOUN
bjp-23565	114	112	after	after	ADP
bjp-23565	114	113	drug	drug	NOUN
bjp-23565	114	114	treatment	treatment	NOUN
bjp-23565	114	115	.	.	PUNCT
bjp-23565	115	1	these	these	DET
bjp-23565	115	2	results	result	NOUN
bjp-23565	115	3	showed	show	VERB
bjp-23565	115	4	that	that	SCONJ
bjp-23565	115	5	paclitaxel	paclitaxel	NOUN
bjp-23565	115	6	and	and	CCONJ
bjp-23565	115	7	trastuzumab	trastuzumab	NOUN
bjp-23565	115	8	treated	treat	VERB
bjp-23565	115	9	cells	cell	NOUN
bjp-23565	115	10	induced	induce	VERB
bjp-23565	115	11	apoptosis	apoptosis	NOUN
bjp-23565	115	12	.	.	PUNCT
bjp-23565	116	1	conclusion	conclusion	NOUN
bjp-23565	116	2	the	the	DET
bjp-23565	116	3	combined	combined	ADJ
bjp-23565	116	4	paclitaxel	paclitaxel	NOUN
bjp-23565	116	5	and	and	CCONJ
bjp-23565	116	6	trastuzumab	trastuzumab	NOUN
bjp-23565	116	7	treatment	treatment	NOUN
bjp-23565	116	8	potentially	potentially	ADV
bjp-23565	116	9	inhibited	inhibit	VERB
bjp-23565	116	10	the	the	DET
bjp-23565	116	11	growth	growth	NOUN
bjp-23565	116	12	of	of	ADP
bjp-23565	116	13	both	both	PRON
bjp-23565	116	14	t47d	t47d	PRON
bjp-23565	116	15	and	and	CCONJ
bjp-23565	116	16	hs0578	hs0578	PROPN
bjp-23565	116	17	t	t	NOUN
bjp-23565	116	18	cells	cell	NOUN
bjp-23565	116	19	by	by	ADP
bjp-23565	116	20	down	down	ADP
bjp-23565	116	21	regulating	regulate	VERB
bjp-23565	116	22	igf	igf	NOUN
bjp-23565	116	23	signaling	signal	VERB
bjp-23565	116	24	molecules	molecule	NOUN
bjp-23565	116	25	.	.	PUNCT
bjp-23565	117	1	further	far	ADV
bjp-23565	117	2	,	,	PUNCT
bjp-23565	117	3	combination	combination	NOUN
bjp-23565	117	4	of	of	ADP
bjp-23565	117	5	paclitaxel	paclitaxel	PROPN
bjp-23565	117	6	and	and	CCONJ
bjp-23565	117	7	trastuzumab	trastuzumab	NOUN
bjp-23565	117	8	acts	act	NOUN
bjp-23565	117	9	as	as	ADP
bjp-23565	117	10	an	an	DET
bjp-23565	117	11	inhibitor	inhibitor	NOUN
bjp-23565	117	12	of	of	ADP
bjp-23565	117	13	igf-1r	igf-1r	PROPN
bjp-23565	117	14	/	/	SYM
bjp-23565	117	15	akt	akt	PROPN
bjp-23565	117	16	/	/	SYM
bjp-23565	117	17	erk	erk	PROPN
bjp-23565	117	18	signaling	signal	VERB
bjp-23565	117	19	.	.	PUNCT
bjp-23565	118	1	these	these	DET
bjp-23565	118	2	inhibition	inhibition	NOUN
bjp-23565	118	3	in	in	ADP
bjp-23565	118	4	growth	growth	NOUN
bjp-23565	118	5	was	be	AUX
bjp-23565	118	6	due	due	ADJ
bjp-23565	118	7	to	to	ADP
bjp-23565	118	8	the	the	DET
bjp-23565	118	9	accumulation	accumulation	NOUN
bjp-23565	118	10	of	of	ADP
bjp-23565	118	11	g0	g0	PROPN
bjp-23565	118	12	/	/	SYM
bjp-23565	118	13	g1	g1	PROPN
bjp-23565	118	14	cells	cell	NOUN
bjp-23565	118	15	and	and	CCONJ
bjp-23565	118	16	reduced	reduced	ADJ
bjp-23565	118	17	expression	expression	NOUN
bjp-23565	118	18	of	of	ADP
bjp-23565	118	19	cyclin	cyclin	NOUN
bjp-23565	118	20	proteins	protein	NOUN
bjp-23565	118	21	.	.	PUNCT
bjp-23565	119	1	thus	thus	ADV
bjp-23565	119	2	the	the	DET
bjp-23565	119	3	combined	combine	VERB
bjp-23565	119	4	drugs	drug	NOUN
bjp-23565	119	5	can	can	AUX
bjp-23565	119	6	serve	serve	VERB
bjp-23565	119	7	as	as	ADP
bjp-23565	119	8	an	an	DET
bjp-23565	119	9	promising	promising	ADJ
bjp-23565	119	10	candidates	candidate	NOUN
bjp-23565	119	11	for	for	ADP
bjp-23565	119	12	breast	breast	NOUN
bjp-23565	119	13	cancer	cancer	NOUN
bjp-23565	119	14	treatment	treatment	NOUN
bjp-23565	119	15	.	.	PUNCT
bjp-23565	120	1	references	reference	NOUN
bjp-23565	120	2	baselga	baselga	ADJ
bjp-23565	120	3	j	j	PROPN
bjp-23565	120	4	,	,	PUNCT
bjp-23565	120	5	cortés	cortés	PROPN
bjp-23565	120	6	j	j	PROPN
bjp-23565	120	7	,	,	PUNCT
bjp-23565	120	8	kim	kim	PROPN
bjp-23565	120	9	sb	sb	PROPN
bjp-23565	120	10	,	,	PUNCT
bjp-23565	120	11	i	i	PROPN
bjp-23565	120	12	m	m	PROPN
bjp-23565	120	13	sa	sa	PROPN
bjp-23565	120	14	,	,	PUNCT
bjp-23565	120	15	hegg	hegg	PROPN
bjp-23565	120	16	r	r	NOUN
bjp-23565	120	17	,	,	PUNCT
bjp-23565	120	18	i	i	PRON
bjp-23565	120	19	m	m	VERB
bjp-23565	120	20	yh	yh	PROPN
bjp-23565	120	21	,	,	PUNCT
bjp-23565	120	22	roman	roman	ADJ
bjp-23565	120	23	l	l	NOUN
bjp-23565	120	24	,	,	PUNCT
bjp-23565	120	25	pedrini	pedrini	PROPN
bjp-23565	120	26	jl	jl	NOUN
bjp-23565	120	27	,	,	PUNCT
bjp-23565	120	28	pienkowski	pienkowski	PROPN
bjp-23565	120	29	t	t	PROPN
bjp-23565	120	30	,	,	PUNCT
bjp-23565	120	31	knott	knott	PROPN
bjp-23565	120	32	a	a	PROPN
bjp-23565	120	33	,	,	PUNCT
bjp-23565	120	34	clark	clark	PROPN
bjp-23565	120	35	e	e	PROPN
bjp-23565	120	36	,	,	PUNCT
bjp-23565	120	37	benyunes	benyunes	PROPN
bjp-23565	120	38	mc	mc	PROPN
bjp-23565	120	39	,	,	PUNCT
bjp-23565	120	40	ross	ross	PROPN
bjp-23565	120	41	g	g	PROPN
bjp-23565	120	42	,	,	PUNCT
bjp-23565	120	43	swain	swain	PROPN
bjp-23565	120	44	sm	sm	PROPN
bjp-23565	120	45	;	;	PUNCT
bjp-23565	120	46	cleopatra	cleopatra	PROPN
bjp-23565	120	47	study	study	NOUN
bjp-23565	120	48	group	group	PROPN
bjp-23565	120	49	.	.	PUNCT
bjp-23565	121	1	pertuzumab	pertuzumab	PROPN
bjp-23565	121	2	plus	plus	CCONJ
bjp-23565	121	3	trastuzumab	trastuzumab	NOUN
bjp-23565	121	4	plus	plus	CCONJ
bjp-23565	121	5	docetaxel	docetaxel	NOUN
bjp-23565	121	6	for	for	ADP
bjp-23565	121	7	metastatic	metastatic	ADJ
bjp-23565	121	8	breast	breast	NOUN
bjp-23565	121	9	cancer	cancer	NOUN
bjp-23565	121	10	.	.	PUNCT
bjp-23565	122	1	n	n	PROPN
bjp-23565	122	2	engl	engl	PROPN
bjp-23565	122	3	j	j	PROPN
bjp-23565	122	4	med	med	PROPN
bjp-23565	122	5	.	.	PROPN
bjp-23565	122	6	2012	2012	NUM
bjp-23565	122	7	;	;	PUNCT
bjp-23565	122	8	366	366	NUM
bjp-23565	122	9	:	:	PUNCT
bjp-23565	122	10	109	109	NUM
bjp-23565	122	11	-	-	SYM
bjp-23565	122	12	19	19	NUM
bjp-23565	122	13	.	.	PUNCT
bjp-23565	122	14	becker	becker	PROPN
bjp-23565	122	15	ma	ma	PROPN
bjp-23565	122	16	,	,	PUNCT
bjp-23565	122	17	ibrahim	ibrahim	PROPN
bjp-23565	122	18	yh	yh	PROPN
bjp-23565	122	19	,	,	PUNCT
bjp-23565	122	20	cui	cui	NOUN
bjp-23565	122	21	x	x	PROPN
bjp-23565	122	22	,	,	PUNCT
bjp-23565	122	23	lee	lee	PROPN
bjp-23565	122	24	av	av	PROPN
bjp-23565	122	25	,	,	PUNCT
bjp-23565	122	26	yee	yee	PROPN
bjp-23565	122	27	d.	d.	PROPN
bjp-23565	122	28	the	the	DET
bjp-23565	122	29	igf	igf	PROPN
bjp-23565	122	30	pathway	pathway	NOUN
bjp-23565	122	31	regulates	regulate	VERB
bjp-23565	122	32	erα	erα	NOUN
bjp-23565	122	33	through	through	ADP
bjp-23565	122	34	a	a	DET
bjp-23565	122	35	s6k1	s6k1	NOUN
bjp-23565	122	36	-	-	ADJ
bjp-23565	122	37	dependent	dependent	ADJ
bjp-23565	122	38	mechanism	mechanism	NOUN
bjp-23565	122	39	in	in	ADP
bjp-23565	122	40	breast	breast	NOUN
bjp-23565	122	41	cancer	cancer	NOUN
bjp-23565	122	42	cells	cell	NOUN
bjp-23565	122	43	.	.	PUNCT
bjp-23565	123	1	mol	mol	ADP
bjp-23565	123	2	endocrinol	endocrinol	NOUN
bjp-23565	123	3	.	.	PUNCT
bjp-23565	124	1	2011	2011	NUM
bjp-23565	124	2	;	;	PUNCT
bjp-23565	125	1	25	25	NUM
bjp-23565	125	2	:	:	PUNCT
bjp-23565	125	3	516–28	516–28	NUM
bjp-23565	125	4	.	.	PUNCT
bjp-23565	126	1	chou	chou	PROPN
bjp-23565	126	2	tc	tc	PROPN
bjp-23565	126	3	.	.	PUNCT
bjp-23565	127	1	theoretical	theoretical	ADJ
bjp-23565	127	2	basis	basis	NOUN
bjp-23565	127	3	,	,	PUNCT
bjp-23565	127	4	experimental	experimental	ADJ
bjp-23565	127	5	design	design	NOUN
bjp-23565	127	6	,	,	PUNCT
bjp-23565	127	7	and	and	CCONJ
bjp-23565	127	8	computerized	computerized	ADJ
bjp-23565	127	9	simulation	simulation	NOUN
bjp-23565	127	10	of	of	ADP
bjp-23565	127	11	synergism	synergism	NOUN
bjp-23565	127	12	and	and	CCONJ
bjp-23565	127	13	antagonism	antagonism	NOUN
bjp-23565	127	14	in	in	ADP
bjp-23565	127	15	drug	drug	NOUN
bjp-23565	127	16	combination	combination	NOUN
bjp-23565	127	17	studies	study	NOUN
bjp-23565	127	18	.	.	PUNCT
bjp-23565	128	1	pharmacol	pharmacol	PROPN
bjp-23565	128	2	rev	rev	PROPN
bjp-23565	128	3	.	.	PROPN
bjp-23565	128	4	2006	2006	NUM
bjp-23565	128	5	;	;	PUNCT
bjp-23565	128	6	58	58	NUM
bjp-23565	128	7	:	:	PUNCT
bjp-23565	128	8	621–81	621–81	PROPN
bjp-23565	128	9	.	.	PUNCT
bjp-23565	129	1	figueroa	figueroa	PROPN
bjp-23565	129	2	ja	ja	PROPN
bjp-23565	129	3	,	,	PUNCT
bjp-23565	129	4	yee	yee	PROPN
bjp-23565	129	5	d.	d.	PROPN
bjp-23565	129	6	the	the	DET
bjp-23565	129	7	insulin	insulin	NOUN
bjp-23565	129	8	-	-	PUNCT
bjp-23565	129	9	like	like	ADJ
bjp-23565	129	10	growth	growth	NOUN
bjp-23565	129	11	factor	factor	NOUN
bjp-23565	129	12	binding	bind	VERB
bjp-23565	129	13	proteins	protein	NOUN
bjp-23565	129	14	(	(	PUNCT
bjp-23565	129	15	igfbps	igfbps	NOUN
bjp-23565	129	16	)	)	PUNCT
bjp-23565	129	17	in	in	ADP
bjp-23565	129	18	human	human	ADJ
bjp-23565	129	19	breast	breast	NOUN
bjp-23565	129	20	cancer	cancer	NOUN
bjp-23565	129	21	.	.	PUNCT
bjp-23565	130	1	breast	breast	NOUN
bjp-23565	130	2	cancer	cancer	NOUN
bjp-23565	130	3	res	re	NOUN
bjp-23565	130	4	treat	treat	NOUN
bjp-23565	130	5	.	.	PUNCT
bjp-23565	131	1	1992	1992	NUM
bjp-23565	131	2	;	;	PUNCT
bjp-23565	131	3	22	22	NUM
bjp-23565	131	4	:	:	SYM
bjp-23565	131	5	81	81	NUM
bjp-23565	131	6	-	-	SYM
bjp-23565	131	7	90	90	NUM
bjp-23565	131	8	.	.	PUNCT
bjp-23565	132	1	holmes	holmes	PROPN
bjp-23565	132	2	fa	fa	PROPN
bjp-23565	132	3	,	,	PUNCT
bjp-23565	132	4	walters	walters	PROPN
bjp-23565	132	5	rs	rs	PROPN
bjp-23565	132	6	,	,	PUNCT
bjp-23565	132	7	theriault	theriault	VERB
bjp-23565	132	8	rl	rl	PROPN
bjp-23565	132	9	,	,	PUNCT
bjp-23565	132	10	forman	forman	NOUN
bjp-23565	132	11	ad	ad	NOUN
bjp-23565	132	12	,	,	PUNCT
bjp-23565	132	13	newton	newton	PROPN
bjp-23565	132	14	lk	lk	PROPN
bjp-23565	132	15	,	,	PUNCT
bjp-23565	132	16	raber	raber	PROPN
bjp-23565	132	17	mn	mn	PROPN
bjp-23565	132	18	,	,	PUNCT
bjp-23565	132	19	buzdar	buzdar	PROPN
bjp-23565	132	20	au	au	PROPN
bjp-23565	132	21	,	,	PUNCT
bjp-23565	132	22	frye	frye	PROPN
bjp-23565	132	23	dk	dk	PROPN
bjp-23565	132	24	,	,	PUNCT
bjp-23565	132	25	hortobagyi	hortobagyi	PROPN
bjp-23565	132	26	gn	gn	PROPN
bjp-23565	132	27	.	.	PROPN
bjp-23565	132	28	phase	phase	PROPN
bjp-23565	132	29	ii	ii	NOUN
bjp-23565	132	30	trial	trial	NOUN
bjp-23565	132	31	of	of	ADP
bjp-23565	132	32	taxol	taxol	PROPN
bjp-23565	132	33	,	,	PUNCT
bjp-23565	132	34	an	an	DET
bjp-23565	132	35	active	active	ADJ
bjp-23565	132	36	drug	drug	NOUN
bjp-23565	132	37	in	in	ADP
bjp-23565	132	38	the	the	DET
bjp-23565	132	39	treatment	treatment	NOUN
bjp-23565	132	40	of	of	ADP
bjp-23565	132	41	metastaatic	metastaatic	ADJ
bjp-23565	132	42	breast	breast	NOUN
bjp-23565	132	43	cancer	cancer	NOUN
bjp-23565	132	44	.	.	PUNCT
bjp-23565	133	1	j	j	PROPN
bjp-23565	133	2	natl	natl	PROPN
bjp-23565	133	3	cancer	cancer	PROPN
bjp-23565	133	4	inst	inst	PROPN
bjp-23565	133	5	.	.	PROPN
bjp-23565	133	6	1991	1991	NUM
bjp-23565	133	7	;	;	PUNCT
bjp-23565	133	8	83	83	NUM
bjp-23565	133	9	:	:	SYM
bjp-23565	133	10	1797	1797	NUM
bjp-23565	133	11	-	-	SYM
bjp-23565	133	12	805	805	NUM
bjp-23565	133	13	.	.	PUNCT
bjp-23565	134	1	jones	jones	PROPN
bjp-23565	134	2	ji	ji	PROPN
bjp-23565	134	3	,	,	PUNCT
bjp-23565	134	4	clemmons	clemmons	PROPN
bjp-23565	134	5	dr	dr	PROPN
bjp-23565	134	6	.	.	PROPN
bjp-23565	134	7	insulin	insulin	PROPN
bjp-23565	134	8	-	-	PUNCT
bjp-23565	134	9	like	like	ADJ
bjp-23565	134	10	growth	growth	NOUN
bjp-23565	134	11	factors	factor	NOUN
bjp-23565	134	12	and	and	CCONJ
bjp-23565	134	13	their	their	PRON
bjp-23565	134	14	binding	bind	VERB
bjp-23565	134	15	proteins	protein	NOUN
bjp-23565	134	16	:	:	PUNCT
bjp-23565	134	17	biological	biological	ADJ
bjp-23565	134	18	actions	action	NOUN
bjp-23565	134	19	.	.	PUNCT
bjp-23565	135	1	endocr	endocr	PROPN
bjp-23565	135	2	rev	rev	PROPN
bjp-23565	135	3	.	.	PROPN
bjp-23565	135	4	1995	1995	NUM
bjp-23565	135	5	;	;	PUNCT
bjp-23565	135	6	16	16	NUM
bjp-23565	135	7	:	:	SYM
bjp-23565	135	8	334	334	NUM
bjp-23565	135	9	.	.	PUNCT
bjp-23565	136	1	kang	kang	PROPN
bjp-23565	136	2	hj	hj	PROPN
bjp-23565	136	3	,	,	PUNCT
bjp-23565	136	4	yi	yi	PROPN
bjp-23565	136	5	yw	yw	PROPN
bjp-23565	136	6	,	,	PUNCT
bjp-23565	136	7	kim	kim	PROPN
bjp-23565	136	8	hj	hj	PROPN
bjp-23565	136	9	,	,	PUNCT
bjp-23565	136	10	hong	hong	PROPN
bjp-23565	136	11	yb	yb	PROPN
bjp-23565	136	12	,	,	PUNCT
bjp-23565	136	13	seong	seong	PROPN
bjp-23565	136	14	ys	ys	PROPN
bjp-23565	136	15	,	,	PUNCT
bjp-23565	136	16	bae	bae	PROPN
bjp-23565	136	17	i.	i.	PROPN
bjp-23565	136	18	brca1	brca1	PROPN
bjp-23565	136	19	negatively	negatively	ADV
bjp-23565	136	20	regulates	regulate	VERB
bjp-23565	136	21	igf-1	igf-1	NOUN
bjp-23565	136	22	expression	expression	NOUN
bjp-23565	136	23	through	through	ADP
bjp-23565	136	24	an	an	DET
bjp-23565	136	25	estrogenresponsive	estrogenresponsive	ADJ
bjp-23565	136	26	element	element	NOUN
bjp-23565	136	27	-	-	PUNCT
bjp-23565	136	28	like	like	ADJ
bjp-23565	136	29	site	site	NOUN
bjp-23565	136	30	.	.	PUNCT
bjp-23565	137	1	cell	cell	NOUN
bjp-23565	137	2	death	death	NOUN
bjp-23565	137	3	dis	dis	PROPN
bjp-23565	137	4	.	.	PUNCT
bjp-23565	138	1	2012	2012	NUM
bjp-23565	138	2	;	;	PUNCT
bjp-23565	138	3	3	3	NUM
bjp-23565	138	4	:	:	PUNCT
bjp-23565	138	5	e336	e336	PROPN
bjp-23565	138	6	.	.	PUNCT
bjp-23565	139	1	kim	kim	PROPN
bjp-23565	139	2	hs	hs	PROPN
bjp-23565	139	3	,	,	PUNCT
bjp-23565	139	4	ingermann	ingermann	PROPN
bjp-23565	139	5	ar	ar	PROPN
bjp-23565	139	6	,	,	PUNCT
bjp-23565	139	7	tsubaki	tsubaki	PROPN
bjp-23565	139	8	j	j	PROPN
bjp-23565	139	9	,	,	PUNCT
bjp-23565	139	10	twigg	twigg	PROPN
bjp-23565	139	11	sm	sm	PROPN
bjp-23565	139	12	,	,	PUNCT
bjp-23565	139	13	walker	walker	PROPN
bjp-23565	139	14	ge	ge	PROPN
bjp-23565	139	15	,	,	PUNCT
bjp-23565	140	1	oh	oh	INTJ
bjp-23565	140	2	y.	y.	NOUN
bjp-23565	140	3	insulin	insulin	NOUN
bjp-23565	140	4	-	-	PUNCT
bjp-23565	140	5	like	like	ADJ
bjp-23565	140	6	growth	growth	NOUN
bjp-23565	140	7	factor	factor	NOUN
bjp-23565	140	8	binding	bind	VERB
bjp-23565	140	9	protein	protein	NOUN
bjp-23565	140	10	3	3	NUM
bjp-23565	140	11	induces	induce	VERB
bjp-23565	140	12	caspase	caspase	PROPN
bjp-23565	140	13	dependent	dependent	ADJ
bjp-23565	140	14	apoptosis	apoptosis	NOUN
bjp-23565	140	15	through	through	ADP
bjp-23565	140	16	a	a	DET
bjp-23565	140	17	death	death	NOUN
bjp-23565	140	18	receptormediated	receptormediate	VERB
bjp-23565	140	19	pathway	pathway	NOUN
bjp-23565	140	20	in	in	ADP
bjp-23565	140	21	mcf7	mcf7	PROPN
bjp-23565	140	22	human	human	ADJ
bjp-23565	140	23	breast	breast	NOUN
bjp-23565	140	24	cancer	cancer	NOUN
bjp-23565	140	25	cells	cell	NOUN
bjp-23565	140	26	.	.	PUNCT
bjp-23565	141	1	cancer	cancer	NOUN
bjp-23565	141	2	res	re	NOUN
bjp-23565	141	3	.	.	PUNCT
bjp-23565	142	1	2004;	2004;	PROPN
bjp-23565	142	2	64	64	NUM
bjp-23565	142	3	:	:	PUNCT
bjp-23565	142	4	2229–37	2229–37	NUM
bjp-23565	142	5	.	.	PUNCT
bjp-23565	143	1	le	le	X
bjp-23565	144	1	roith	roith	ADP
bjp-23565	144	2	d	d	PROPN
bjp-23565	144	3	,	,	PUNCT
bjp-23565	144	4	bondy	bondy	PROPN
bjp-23565	144	5	c	c	PROPN
bjp-23565	144	6	,	,	PUNCT
bjp-23565	144	7	yakar	yakar	NOUN
bjp-23565	144	8	s	s	PART
bjp-23565	144	9	,	,	PUNCT
bjp-23565	144	10	liu	liu	PROPN
bjp-23565	144	11	j.	j.	PROPN
bjp-23565	144	12	the	the	DET
bjp-23565	144	13	somatomedin	somatomedin	PROPN
bjp-23565	144	14	hypothesis	hypothesis	NOUN
bjp-23565	144	15	:	:	PUNCT
bjp-23565	144	16	2001	2001	NUM
bjp-23565	144	17	.	.	PUNCT
bjp-23565	145	1	endocr	endocr	PROPN
bjp-23565	145	2	rev	rev	PROPN
bjp-23565	145	3	.	.	PROPN
bjp-23565	145	4	2001	2001	NUM
bjp-23565	145	5	;	;	PUNCT
bjp-23565	145	6	22	22	NUM
bjp-23565	145	7	:	:	PUNCT
bjp-23565	145	8	53	53	NUM
bjp-23565	145	9	-	-	SYM
bjp-23565	145	10	74	74	NUM
bjp-23565	145	11	.	.	PUNCT
bjp-23565	146	1	li	li	PROPN
bjp-23565	146	2	bd	bd	PROPN
bjp-23565	146	3	,	,	PUNCT
bjp-23565	146	4	khosravi	khosravi	PROPN
bjp-23565	146	5	mj	mj	PROPN
bjp-23565	146	6	,	,	PUNCT
bjp-23565	146	7	berkel	berkel	PROPN
bjp-23565	146	8	hj	hj	PROPN
bjp-23565	146	9	,	,	PUNCT
bjp-23565	146	10	diamandi	diamandi	NOUN
bjp-23565	146	11	a	a	PRON
bjp-23565	146	12	,	,	PUNCT
bjp-23565	146	13	dayton	dayton	PROPN
bjp-23565	146	14	ma	ma	PROPN
bjp-23565	146	15	,	,	PUNCT
bjp-23565	146	16	smith	smith	PROPN
bjp-23565	146	17	m	m	PROPN
bjp-23565	146	18	,	,	PUNCT
bjp-23565	146	19	yu	yu	PROPN
bjp-23565	146	20	h.	h.	PROPN
bjp-23565	146	21	free	free	ADJ
bjp-23565	146	22	insulin	insulin	NOUN
bjp-23565	146	23	like	like	ADP
bjp-23565	146	24	growth	growth	NOUN
bjp-23565	146	25	factor	factor	NOUN
bjp-23565	146	26	i	i	PROPN
bjp-23565	146	27	and	and	CCONJ
bjp-23565	146	28	breast	breast	NOUN
bjp-23565	146	29	cancer	cancer	NOUN
bjp-23565	146	30	risk	risk	NOUN
bjp-23565	146	31	.	.	PUNCT
bjp-23565	147	1	int	int	NOUN
bjp-23565	147	2	j	j	PROPN
bjp-23565	147	3	cancer	cancer	NOUN
bjp-23565	147	4	.	.	PUNCT
bjp-23565	148	1	2001;	2001;	NOUN
bjp-23565	148	2	91	91	NUM
bjp-23565	148	3	:	:	PUNCT
bjp-23565	148	4	736–39	736–39	NUM
bjp-23565	148	5	.	.	PUNCT
bjp-23565	149	1	lowry	lowry	PROPN
bjp-23565	149	2	oh	oh	INTJ
bjp-23565	149	3	,	,	PUNCT
bjp-23565	149	4	rosebrough	rosebrough	PROPN
bjp-23565	149	5	nj	nj	PROPN
bjp-23565	149	6	,	,	PUNCT
bjp-23565	149	7	farr	farr	PROPN
bjp-23565	149	8	al	al	PROPN
bjp-23565	149	9	,	,	PUNCT
bjp-23565	149	10	randall	randall	PROPN
bjp-23565	149	11	rj	rj	PROPN
bjp-23565	149	12	.	.	PUNCT
bjp-23565	150	1	protein	protein	NOUN
bjp-23565	150	2	measurement	measurement	NOUN
bjp-23565	150	3	with	with	ADP
bjp-23565	150	4	the	the	DET
bjp-23565	150	5	folin	folin	PROPN
bjp-23565	150	6	phenol	phenol	NOUN
bjp-23565	150	7	reagent	reagent	NOUN
bjp-23565	150	8	.	.	PUNCT
bjp-23565	151	1	j	j	PROPN
bjp-23565	151	2	biol	biol	PROPN
bjp-23565	151	3	chem	chem	NOUN
bjp-23565	151	4	.	.	PUNCT
bjp-23565	152	1	1951	1951	NUM
bjp-23565	152	2	;	;	PUNCT
bjp-23565	152	3	193	193	NUM
bjp-23565	152	4	:	:	PUNCT
bjp-23565	152	5	265–75	265–75	NUM
bjp-23565	152	6	.	.	X
bjp-23565	153	1	lu	lu	PROPN
bjp-23565	153	2	y	y	PROPN
bjp-23565	153	3	,	,	PUNCT
bjp-23565	153	4	zi	zi	PROPN
bjp-23565	153	5	x	x	PROPN
bjp-23565	153	6	,	,	PUNCT
bjp-23565	153	7	zhao	zhao	PROPN
bjp-23565	153	8	y	y	PROPN
bjp-23565	153	9	,	,	PUNCT
bjp-23565	153	10	mascarenhas	mascarenhas	PROPN
bjp-23565	153	11	d	d	PROPN
bjp-23565	153	12	,	,	PUNCT
bjp-23565	153	13	pollak	pollak	PROPN
bjp-23565	153	14	m.insulinlike	m.insulinlike	NOUN
bjp-23565	153	15	growth	growth	NOUN
bjp-23565	153	16	factori	factori	ADJ
bjp-23565	153	17	receptor	receptor	NOUN
bjp-23565	153	18	signaling	signal	VERB
bjp-23565	153	19	and	and	CCONJ
bjp-23565	153	20	resistance	resistance	NOUN
bjp-23565	153	21	to	to	ADP
bjp-23565	153	22	trastuzumab	trastuzumab	NOUN
bjp-23565	153	23	(	(	PUNCT
bjp-23565	153	24	herceptin	herceptin	PROPN
bjp-23565	153	25	)	)	PUNCT
bjp-23565	153	26	.	.	PUNCT
bjp-23565	154	1	j	j	PROPN
bjp-23565	154	2	natl	natl	PROPN
bjp-23565	154	3	cancer	cancer	PROPN
bjp-23565	154	4	inst	inst	PROPN
bjp-23565	154	5	.	.	PUNCT
bjp-23565	155	1	2001;	2001;	NOUN
bjp-23565	155	2	93	93	NUM
bjp-23565	155	3	:	:	SYM
bjp-23565	155	4	1852	1852	NUM
bjp-23565	155	5	–	–	PUNCT
bjp-23565	155	6	57	57	NUM
bjp-23565	155	7	.	.	PUNCT
bjp-23565	156	1	manfredi	manfredi	PROPN
bjp-23565	156	2	jj	jj	PROPN
bjp-23565	156	3	,	,	PUNCT
bjp-23565	156	4	horwitz	horwitz	PROPN
bjp-23565	156	5	sb	sb	PROPN
bjp-23565	156	6	.	.	PROPN
bjp-23565	156	7	taxol	taxol	PROPN
bjp-23565	156	8	:	:	PUNCT
bjp-23565	156	9	an	an	DET
bjp-23565	156	10	antimitotic	antimitotic	ADJ
bjp-23565	156	11	agent	agent	NOUN
bjp-23565	156	12	with	with	ADP
bjp-23565	156	13	a	a	DET
bjp-23565	156	14	unique	unique	ADJ
bjp-23565	156	15	mechanism	mechanism	NOUN
bjp-23565	156	16	of	of	ADP
bjp-23565	156	17	action	action	NOUN
bjp-23565	156	18	.	.	PUNCT
bjp-23565	157	1	pharmacol	pharmacol	VERB
bjp-23565	157	2	ther	ther	ADV
bjp-23565	157	3	.	.	PUNCT
bjp-23565	158	1	1984	1984	NUM
bjp-23565	158	2	;	;	PUNCT
bjp-23565	158	3	25	25	NUM
bjp-23565	158	4	:	:	SYM
bjp-23565	158	5	83125	83125	NUM
bjp-23565	158	6	.	.	PUNCT
bjp-23565	159	1	manning	man	VERB
bjp-23565	159	2	bd	bd	PROPN
bjp-23565	159	3	,	,	PUNCT
bjp-23565	159	4	cantley	cantley	PROPN
bjp-23565	159	5	lc	lc	PROPN
bjp-23565	159	6	.	.	PUNCT
bjp-23565	160	1	akt	akt	PROPN
bjp-23565	160	2	/	/	SYM
bjp-23565	160	3	pkb	pkb	PROPN
bjp-23565	160	4	signaling	signal	VERB
bjp-23565	160	5	:	:	PUNCT
bjp-23565	160	6	navigating	navigate	VERB
bjp-23565	160	7	downstream	downstream	NOUN
bjp-23565	160	8	.	.	PUNCT
bjp-23565	161	1	cell	cell	NOUN
bjp-23565	161	2	2007	2007	NUM
bjp-23565	161	3	;	;	PUNCT
bjp-23565	161	4	129	129	NUM
bjp-23565	161	5	:	:	PUNCT
bjp-23565	161	6	1261–74	1261–74	NUM
bjp-23565	161	7	.	.	PUNCT
bjp-23565	162	1	mcguire	mcguire	PROPN
bjp-23565	162	2	wp	wp	PROPN
bjp-23565	162	3	,	,	PUNCT
bjp-23565	162	4	rowinsky	rowinsky	PROPN
bjp-23565	162	5	ek	ek	PROPN
bjp-23565	162	6	,	,	PUNCT
bjp-23565	162	7	rosenshein	rosenshein	PROPN
bjp-23565	162	8	nb	nb	PROPN
bjp-23565	162	9	,	,	PUNCT
bjp-23565	162	10	grumbine	grumbine	PROPN
bjp-23565	162	11	fc	fc	PROPN
bjp-23565	162	12	,	,	PUNCT
bjp-23565	162	13	ettinger	ettinger	PROPN
bjp-23565	162	14	ds	ds	PROPN
bjp-23565	162	15	,	,	PUNCT
bjp-23565	162	16	armstrong	armstrong	PROPN
bjp-23565	162	17	dk	dk	PROPN
bjp-23565	162	18	,	,	PUNCT
bjp-23565	162	19	donehower	donehower	PROPN
bjp-23565	162	20	rc	rc	PROPN
bjp-23565	162	21	.	.	PROPN
bjp-23565	162	22	taxol	taxol	PROPN
bjp-23565	162	23	:	:	PUNCT
bjp-23565	162	24	a	a	DET
bjp-23565	162	25	unique	unique	ADJ
bjp-23565	162	26	antineoplastic	antineoplastic	ADJ
bjp-23565	162	27	agent	agent	NOUN
bjp-23565	162	28	with	with	ADP
bjp-23565	162	29	significant	significant	ADJ
bjp-23565	162	30	activity	activity	NOUN
bjp-23565	162	31	in	in	ADP
bjp-23565	162	32	advanced	advanced	ADJ
bjp-23565	162	33	ovarian	ovarian	ADJ
bjp-23565	162	34	epithelial	epithelial	ADJ
bjp-23565	162	35	neoplasms	neoplasm	NOUN
bjp-23565	162	36	.	.	PUNCT
bjp-23565	163	1	ann	ann	PROPN
bjp-23565	163	2	intern	intern	PROPN
bjp-23565	163	3	med	med	PROPN
bjp-23565	163	4	.	.	PROPN
bjp-23565	163	5	1989	1989	NUM
bjp-23565	163	6	;	;	PUNCT
bjp-23565	163	7	111	111	NUM
bjp-23565	163	8	:	:	PUNCT
bjp-23565	163	9	273	273	NUM
bjp-23565	163	10	-	-	SYM
bjp-23565	163	11	79	79	NUM
bjp-23565	163	12	.	.	PUNCT
bjp-23565	164	1	menu	menu	PROPN
bjp-23565	164	2	e	e	NOUN
bjp-23565	164	3	,	,	PUNCT
bjp-23565	164	4	kooijman	kooijman	PROPN
bjp-23565	164	5	r	r	NOUN
bjp-23565	164	6	,	,	PUNCT
bjp-23565	164	7	van	van	NOUN
bjp-23565	164	8	valckenborgh	valckenborgh	PROPN
bjp-23565	164	9	e	e	PROPN
bjp-23565	164	10	,	,	PUNCT
bjp-23565	164	11	asosingh	asosingh	ADJ
bjp-23565	164	12	k	k	NOUN
bjp-23565	164	13	,	,	PUNCT
bjp-23565	164	14	bakkus	bakkus	PROPN
bjp-23565	164	15	m	m	PROPN
bjp-23565	164	16	,	,	PUNCT
bjp-23565	164	17	van	van	PROPN
bjp-23565	164	18	camp	camp	PROPN
bjp-23565	164	19	b	b	PROPN
bjp-23565	164	20	,	,	PUNCT
bjp-23565	164	21	vanderkerken	vanderkerken	VERB
bjp-23565	164	22	k.	k.	NOUN
bjp-23565	164	23	specific	specific	ADJ
bjp-23565	164	24	roles	role	NOUN
bjp-23565	164	25	for	for	ADP
bjp-23565	164	26	the	the	DET
bjp-23565	164	27	pi3k	pi3k	PROPN
bjp-23565	164	28	and	and	CCONJ
bjp-23565	164	29	the	the	DET
bjp-23565	164	30	mek	mek	PROPN
bjp-23565	164	31	-	-	PUNCT
bjp-23565	164	32	erk	erk	PROPN
bjp-23565	164	33	pathway	pathway	NOUN
bjp-23565	164	34	in	in	ADP
bjp-23565	164	35	igf-1	igf-1	ADV
bjp-23565	164	36	-	-	PUNCT
bjp-23565	164	37	stimulated	stimulate	VERB
bjp-23565	164	38	chemotaxis	chemotaxis	NOUN
bjp-23565	164	39	,	,	PUNCT
bjp-23565	164	40	vegf	vegf	PROPN
bjp-23565	164	41	secretion	secretion	NOUN
bjp-23565	164	42	and	and	CCONJ
bjp-23565	164	43	proliferation	proliferation	NOUN
bjp-23565	164	44	of	of	ADP
bjp-23565	164	45	multiple	multiple	ADJ
bjp-23565	164	46	myeloma	myeloma	NOUN
bjp-23565	164	47	cells	cell	NOUN
bjp-23565	164	48	:	:	PUNCT
bjp-23565	164	49	study	study	NOUN
bjp-23565	164	50	in	in	ADP
bjp-23565	164	51	the	the	DET
bjp-23565	164	52	5t33	5t33	NUM
bjp-23565	164	53	mm	mm	PROPN
bjp-23565	164	54	model	model	NOUN
bjp-23565	164	55	.	.	PUNCT
bjp-23565	165	1	br	br	PROPN
bjp-23565	165	2	j	j	PROPN
bjp-23565	165	3	cancer	cancer	NOUN
bjp-23565	165	4	.	.	PUNCT
bjp-23565	166	1	2004	2004	NUM
bjp-23565	166	2	;	;	PUNCT
bjp-23565	166	3	90	90	NUM
bjp-23565	166	4	:	:	SYM
bjp-23565	166	5	1076	1076	NUM
bjp-23565	166	6	-	-	SYM
bjp-23565	166	7	83	83	NUM
bjp-23565	166	8	.	.	PUNCT
bjp-23565	167	1	michels	michels	PROPN
bjp-23565	167	2	kb	kb	PROPN
bjp-23565	167	3	,	,	PUNCT
bjp-23565	167	4	willett	willett	PROPN
bjp-23565	167	5	wc	wc	PROPN
bjp-23565	167	6	.	.	PROPN
bjp-23565	167	7	breast	breast	NOUN
bjp-23565	167	8	cancer	cancer	NOUN
bjp-23565	167	9	-	-	PUNCT
bjp-23565	167	10	early	early	ADJ
bjp-23565	167	11	life	life	NOUN
bjp-23565	167	12	matters	matter	NOUN
bjp-23565	167	13	.	.	PUNCT
bjp-23565	168	1	n	n	X
bjp-23565	168	2	engl	engl	PROPN
bjp-23565	168	3	j	j	PROPN
bjp-23565	168	4	med	me	VERB
bjp-23565	168	5	.	.	PUNCT
bjp-23565	169	1	2004;	2004;	NUM
bjp-23565	169	2	351	351	NUM
bjp-23565	169	3	:	:	PUNCT
bjp-23565	169	4	1679–81	1679–81	NUM
bjp-23565	169	5	.	.	PUNCT
bjp-23565	170	1	nielsen	nielsen	PROPN
bjp-23565	170	2	to	to	ADP
bjp-23565	170	3	,	,	PUNCT
bjp-23565	170	4	andrews	andrews	PROPN
bjp-23565	170	5	hn	hn	PROPN
bjp-23565	170	6	,	,	PUNCT
bjp-23565	170	7	cheang	cheang	PROPN
bjp-23565	170	8	m	m	PROPN
bjp-23565	170	9	,	,	PUNCT
bjp-23565	170	10	kucab	kucab	PROPN
bjp-23565	170	11	je	je	PROPN
bjp-23565	170	12	,	,	PUNCT
bjp-23565	170	13	hsu	hsu	PROPN
bjp-23565	170	14	fd	fd	PROPN
bjp-23565	170	15	,	,	PUNCT
bjp-23565	170	16	ragaz	ragaz	PROPN
bjp-23565	170	17	j	j	PROPN
bjp-23565	170	18	,	,	PUNCT
bjp-23565	170	19	gilks	gilks	PROPN
bjp-23565	170	20	cb	cb	PROPN
bjp-23565	170	21	,	,	PUNCT
bjp-23565	170	22	makretsov	makretsov	NOUN
bjp-23565	170	23	n	n	CCONJ
bjp-23565	170	24	,	,	PUNCT
bjp-23565	170	25	bajdik	bajdik	PROPN
bjp-23565	170	26	cd	cd	PROPN
bjp-23565	170	27	,	,	PUNCT
bjp-23565	170	28	brookes	brook	VERB
bjp-23565	170	29	c	c	PROPN
bjp-23565	170	30	,	,	PUNCT
bjp-23565	170	31	neckers	necker	NOUN
bjp-23565	170	32	lm	lm	VERB
bjp-23565	170	33	,	,	PUNCT
bjp-23565	170	34	evdokimova	evdokimova	X
bjp-23565	170	35	v	v	PROPN
bjp-23565	170	36	,	,	PUNCT
bjp-23565	170	37	huntsman	huntsman	NOUN
bjp-23565	170	38	dg	dg	PROPN
bjp-23565	170	39	,	,	PUNCT
bjp-23565	170	40	dunn	dunn	PROPN
bjp-23565	170	41	se	se	PROPN
bjp-23565	170	42	.	.	PUNCT
bjp-23565	171	1	expression	expression	NOUN
bjp-23565	171	2	of	of	ADP
bjp-23565	171	3	the	the	DET
bjp-23565	171	4	insulin	insulin	NOUN
bjp-23565	171	5	like	like	ADP
bjp-23565	171	6	growth	growth	NOUN
bjp-23565	171	7	factor	factor	NOUN
bjp-23565	171	8	i	i	PRON
bjp-23565	171	9	receptor	receptor	VERB
bjp-23565	171	10	and	and	CCONJ
bjp-23565	171	11	urokinase	urokinase	VERB
bjp-23565	171	12	plasminogen	plasminogen	NOUN
bjp-23565	171	13	activator	activator	NOUN
bjp-23565	171	14	in	in	ADP
bjp-23565	171	15	breast	breast	NOUN
bjp-23565	171	16	cancer	cancer	NOUN
bjp-23565	171	17	is	be	AUX
bjp-23565	171	18	associated	associate	VERB
bjp-23565	171	19	with	with	ADP
bjp-23565	171	20	poor	poor	ADJ
bjp-23565	171	21	survival	survival	NOUN
bjp-23565	171	22	:	:	PUNCT
bjp-23565	171	23	potential	potential	ADJ
bjp-23565	171	24	for	for	ADP
bjp-23565	171	25	intervention	intervention	NOUN
bjp-23565	171	26	with	with	ADP
bjp-23565	171	27	17	17	NUM
bjp-23565	171	28	-	-	PUNCT
bjp-23565	171	29	allylamino	allylamino	NOUN
bjp-23565	171	30	geldanamycin	geldanamycin	NOUN
bjp-23565	171	31	.	.	PUNCT
bjp-23565	172	1	cancer	cancer	NOUN
bjp-23565	172	2	res	re	NOUN
bjp-23565	172	3	.	.	PUNCT
bjp-23565	172	4	2004	2004	NUM
bjp-23565	172	5	;	;	PUNCT
bjp-23565	172	6	64	64	NUM
bjp-23565	172	7	:	:	PUNCT
bjp-23565	172	8	286–91	286–91	NUM
bjp-23565	172	9	.	.	PUNCT
bjp-23565	173	1	papa	papa	PROPN
bjp-23565	173	2	v	v	PROPN
bjp-23565	173	3	,	,	PUNCT
bjp-23565	173	4	gliozzo	gliozzo	PROPN
bjp-23565	173	5	b	b	PROPN
bjp-23565	173	6	,	,	PUNCT
bjp-23565	173	7	clark	clark	PROPN
bjp-23565	173	8	gm	gm	PROPN
bjp-23565	173	9	,	,	PUNCT
bjp-23565	173	10	mcguire	mcguire	PROPN
bjp-23565	173	11	wl	wl	PROPN
bjp-23565	173	12	,	,	PUNCT
bjp-23565	173	13	moore	moore	PROPN
bjp-23565	173	14	d	d	PROPN
bjp-23565	173	15	,	,	PUNCT
bjp-23565	173	16	fujitayamaguchi	fujitayamaguchi	PROPN
bjp-23565	173	17	y	y	PROPN
bjp-23565	173	18	,	,	PUNCT
bjp-23565	173	19	vigneri	vigneri	PROPN
bjp-23565	173	20	r	r	PROPN
bjp-23565	173	21	,	,	PUNCT
bjp-23565	173	22	goldfine	goldfine	NOUN
bjp-23565	173	23	i	i	PROPN
bjp-23565	173	24	d	d	PROPN
bjp-23565	173	25	,	,	PUNCT
bjp-23565	173	26	pezzino	pezzino	NOUN
bjp-23565	173	27	v.	v.	ADP
bjp-23565	173	28	insulin	insulin	NOUN
bjp-23565	173	29	-	-	PUNCT
bjp-23565	173	30	like	like	ADJ
bjp-23565	173	31	growth	growth	NOUN
bjp-23565	173	32	factor	factor	NOUN
bjp-23565	173	33	i	i	PRON
bjp-23565	173	34	receptors	receptor	NOUN
bjp-23565	173	35	are	be	AUX
bjp-23565	173	36	overexpressed	overexpresse	VERB
bjp-23565	173	37	and	and	CCONJ
bjp-23565	173	38	predict	predict	VERB
bjp-23565	173	39	a	a	DET
bjp-23565	173	40	low	low	ADJ
bjp-23565	173	41	risk	risk	NOUN
bjp-23565	173	42	in	in	ADP
bjp-23565	173	43	human	human	ADJ
bjp-23565	173	44	breast	breast	NOUN
bjp-23565	173	45	cancer	cancer	NOUN
bjp-23565	173	46	.	.	PUNCT
bjp-23565	174	1	cancer	cancer	NOUN
bjp-23565	174	2	res	re	NOUN
bjp-23565	174	3	.	.	PUNCT
bjp-23565	175	1	1993;	1993;	PROPN
bjp-23565	175	2	53	53	NUM
bjp-23565	175	3	:	:	SYM
bjp-23565	175	4	3736	3736	NUM
bjp-23565	175	5	–	–	PUNCT
bjp-23565	175	6	40	40	NUM
bjp-23565	175	7	.	.	PUNCT
bjp-23565	176	1	piccart	piccart	NOUN
bjp-23565	176	2	-	-	PUNCT
bjp-23565	176	3	gebhart	gebhart	PROPN
bjp-23565	176	4	mj	mj	PROPN
bjp-23565	176	5	,	,	PUNCT
bjp-23565	176	6	procter	procter	PROPN
bjp-23565	176	7	m	m	PROPN
bjp-23565	176	8	,	,	PUNCT
bjp-23565	176	9	leyland	leyland	PROPN
bjp-23565	176	10	-	-	PUNCT
bjp-23565	176	11	jones	jones	PROPN
bjp-23565	176	12	b	b	PROPN
bjp-23565	176	13	,	,	PUNCT
bjp-23565	176	14	goldhirsch	goldhirsch	VERB
bjp-23565	176	15	a	a	PRON
bjp-23565	176	16	,	,	PUNCT
bjp-23565	176	17	untch	untch	PROPN
bjp-23565	176	18	m	m	PROPN
bjp-23565	176	19	,	,	PUNCT
bjp-23565	176	20	smith	smith	PROPN
bjp-23565	176	21	i	i	PROPN
bjp-23565	176	22	,	,	PUNCT
bjp-23565	176	23	gianni	gianni	PROPN
bjp-23565	176	24	l	l	PROPN
bjp-23565	176	25	,	,	PUNCT
bjp-23565	176	26	baselga	baselga	PROPN
bjp-23565	176	27	j	j	PROPN
bjp-23565	176	28	,	,	PUNCT
bjp-23565	176	29	bell	bell	PROPN
bjp-23565	176	30	r	r	NOUN
bjp-23565	176	31	,	,	PUNCT
bjp-23565	176	32	jackisch	jackisch	NOUN
bjp-23565	176	33	c	c	NOUN
bjp-23565	176	34	,	,	PUNCT
bjp-23565	176	35	cameron	cameron	PROPN
bjp-23565	176	36	d	d	PROPN
bjp-23565	176	37	,	,	PUNCT
bjp-23565	176	38	dowsett	dowsett	PROPN
bjp-23565	176	39	m	m	PROPN
bjp-23565	176	40	,	,	PUNCT
bjp-23565	176	41	barrios	barrios	ADJ
bjp-23565	176	42	ch	ch	NOUN
bjp-23565	176	43	,	,	PUNCT
bjp-23565	176	44	steger	steger	PROPN
bjp-23565	176	45	g	g	PROPN
bjp-23565	176	46	,	,	PUNCT
bjp-23565	176	47	huang	huang	PROPN
bjp-23565	176	48	cs	cs	PROPN
bjp-23565	176	49	,	,	PUNCT
bjp-23565	176	50	andersson	andersson	PROPN
bjp-23565	176	51	m	m	PROPN
bjp-23565	176	52	,	,	PUNCT
bjp-23565	176	53	inbar	inbar	PROPN
bjp-23565	176	54	m	m	PROPN
bjp-23565	176	55	,	,	PUNCT
bjp-23565	176	56	lichinitser	lichinitser	NOUN
bjp-23565	176	57	m	m	PROPN
bjp-23565	176	58	,	,	PUNCT
bjp-23565	176	59	láng	láng	ADJ
bjp-23565	176	60	i	i	PRON
bjp-23565	176	61	,	,	PUNCT
bjp-23565	176	62	nitz	nitz	PROPN
bjp-23565	176	63	u	u	PROPN
bjp-23565	176	64	,	,	PUNCT
bjp-23565	176	65	iwata	iwata	PROPN
bjp-23565	176	66	h	h	PROPN
bjp-23565	176	67	,	,	PUNCT
bjp-23565	176	68	thomssen	thomssen	PROPN
bjp-23565	176	69	c	c	NOUN
bjp-23565	176	70	,	,	PUNCT
bjp-23565	176	71	lohrisch	lohrisch	VERB
bjp-23565	176	72	c	c	NOUN
bjp-23565	176	73	,	,	PUNCT
bjp-23565	176	74	suter	suter	PROPN
bjp-23565	176	75	tm	tm	PROPN
bjp-23565	176	76	,	,	PUNCT
bjp-23565	176	77	rüschoff	rüschoff	PROPN
bjp-23565	176	78	j	j	PROPN
bjp-23565	176	79	,	,	PUNCT
bjp-23565	176	80	suto	suto	PROPN
bjp-23565	176	81	t	t	PROPN
bjp-23565	176	82	,	,	PUNCT
bjp-23565	176	83	greatorex	greatorex	PROPN
bjp-23565	176	84	v	v	NOUN
bjp-23565	176	85	,	,	PUNCT
bjp-23565	176	86	ward	ward	NOUN
bjp-23565	176	87	c	c	NOUN
bjp-23565	176	88	,	,	PUNCT
bjp-23565	176	89	straehle	straehle	PROPN
bjp-23565	176	90	c	c	NOUN
bjp-23565	176	91	,	,	PUNCT
bjp-23565	176	92	mcfadden	mcfadden	PROPN
bjp-23565	176	93	e	e	PROPN
bjp-23565	176	94	,	,	PUNCT
bjp-23565	176	95	dolci	dolci	PROPN
bjp-23565	176	96	ms	ms	PROPN
bjp-23565	176	97	,	,	PUNCT
bjp-23565	176	98	gelber	gelber	PROPN
bjp-23565	176	99	rd	rd	PROPN
bjp-23565	176	100	;	;	PUNCT
bjp-23565	176	101	herceptin	herceptin	PROPN
bjp-23565	176	102	adjuvant	adjuvant	NOUN
bjp-23565	176	103	(	(	PUNCT
bjp-23565	176	104	hera	hera	NOUN
bjp-23565	176	105	)	)	PUNCT
bjp-23565	176	106	trial	trial	NOUN
bjp-23565	176	107	study	study	NOUN
bjp-23565	176	108	team	team	NOUN
bjp-23565	176	109	.	.	PUNCT
bjp-23565	177	1	trastuzumab	trastuzumab	NOUN
bjp-23565	177	2	after	after	ADP
bjp-23565	177	3	adjuvant	adjuvant	ADJ
bjp-23565	177	4	chemotherapy	chemotherapy	NOUN
bjp-23565	177	5	in	in	ADP
bjp-23565	177	6	her2	her2	PROPN
bjp-23565	177	7	-	-	PUNCT
bjp-23565	177	8	positive	positive	ADJ
bjp-23565	177	9	breast	breast	NOUN
bjp-23565	177	10	cancer	cancer	NOUN
bjp-23565	177	11	.	.	PUNCT
bjp-23565	178	1	n	n	PROPN
bjp-23565	178	2	engl	engl	PROPN
bjp-23565	178	3	j	j	PROPN
bjp-23565	178	4	med	med	PROPN
bjp-23565	178	5	.	.	PUNCT
bjp-23565	178	6	2005	2005	NUM
bjp-23565	178	7	;	;	PUNCT
bjp-23565	178	8	353	353	NUM
bjp-23565	178	9	:	:	PUNCT
bjp-23565	178	10	1659–72	1659–72	NUM
bjp-23565	178	11	.	.	PUNCT
bjp-23565	179	1	resnik	resnik	PROPN
bjp-23565	179	2	jl	jl	PROPN
bjp-23565	179	3	,	,	PUNCT
bjp-23565	179	4	reichart	reichart	PROPN
bjp-23565	179	5	db	db	PROPN
bjp-23565	179	6	,	,	PUNCT
bjp-23565	179	7	huey	huey	PROPN
bjp-23565	179	8	k	k	PROPN
bjp-23565	179	9	,	,	PUNCT
bjp-23565	179	10	webster	webster	PROPN
bjp-23565	179	11	nj	nj	PROPN
bjp-23565	179	12	,	,	PUNCT
bjp-23565	179	13	seely	seely	ADV
bjp-23565	179	14	bl	bl	PROPN
bjp-23565	179	15	.	.	PUNCT
bjp-23565	179	16	elevated	elevate	VERB
bjp-23565	179	17	insulin	insulin	NOUN
bjp-23565	179	18	-	-	PUNCT
bjp-23565	179	19	like	like	ADJ
bjp-23565	179	20	growth	growth	NOUN
bjp-23565	179	21	factor	factor	NOUN
bjp-23565	179	22	i	i	PRON
bjp-23565	179	23	receptor	receptor	NOUN
bjp-23565	179	24	autophosphorylation	autophosphorylation	NOUN
bjp-23565	179	25	and	and	CCONJ
bjp-23565	179	26	kinase	kinase	NOUN
bjp-23565	179	27	activity	activity	NOUN
bjp-23565	179	28	in	in	ADP
bjp-23565	179	29	human	human	ADJ
bjp-23565	179	30	breast	breast	NOUN
bjp-23565	179	31	cancer	cancer	NOUN
bjp-23565	179	32	.	.	PUNCT
bjp-23565	180	1	cancer	cancer	NOUN
bjp-23565	180	2	res	re	NOUN
bjp-23565	180	3	.	.	PUNCT
bjp-23565	181	1	1998;	1998;	NUM
bjp-23565	181	2	58	58	NUM
bjp-23565	181	3	:	:	PUNCT
bjp-23565	182	1	1159–64	1159–64	NUM
bjp-23565	182	2	.	.	PUNCT
bjp-23565	183	1	romond	romond	PROPN
bjp-23565	183	2	eh	eh	INTJ
bjp-23565	183	3	,	,	PUNCT
bjp-23565	183	4	perez	perez	PROPN
bjp-23565	183	5	ea	ea	PROPN
bjp-23565	183	6	,	,	PUNCT
bjp-23565	183	7	bryant	bryant	PROPN
bjp-23565	183	8	j	j	PROPN
bjp-23565	183	9	,	,	PUNCT
bjp-23565	183	10	suman	suman	PROPN
bjp-23565	183	11	vj	vj	PROPN
bjp-23565	183	12	,	,	PUNCT
bjp-23565	183	13	geyer	geyer	PROPN
bjp-23565	183	14	ce	ce	PROPN
bjp-23565	183	15	jr	jr	PROPN
bjp-23565	183	16	,	,	PUNCT
bjp-23565	183	17	davidson	davidson	PROPN
bjp-23565	183	18	ne	ne	PROPN
bjp-23565	183	19	,	,	PUNCT
bjp-23565	183	20	tan	tan	PROPN
bjp-23565	183	21	-	-	NOUN
bjp-23565	183	22	chiu	chiu	PROPN
bjp-23565	183	23	e	e	PROPN
bjp-23565	183	24	,	,	PUNCT
bjp-23565	183	25	martino	martino	PROPN
bjp-23565	183	26	s	s	PROPN
bjp-23565	183	27	,	,	PUNCT
bjp-23565	183	28	paik	paik	PROPN
bjp-23565	183	29	s	s	PROPN
bjp-23565	183	30	,	,	PUNCT
bjp-23565	183	31	kaufman	kaufman	PROPN
bjp-23565	183	32	pa	pa	PROPN
bjp-23565	183	33	,	,	PUNCT
bjp-23565	183	34	swain	swain	PROPN
bjp-23565	183	35	sm	sm	PROPN
bjp-23565	183	36	,	,	PUNCT
bjp-23565	183	37	pisansky	pisansky	ADJ
bjp-23565	183	38	tm	tm	NOUN
bjp-23565	183	39	,	,	PUNCT
bjp-23565	183	40	fehrenbacher	fehrenbacher	NOUN
bjp-23565	183	41	l	l	NOUN
bjp-23565	183	42	,	,	PUNCT
bjp-23565	183	43	kutteh	kutteh	PROPN
bjp-23565	183	44	la	la	PROPN
bjp-23565	183	45	,	,	PUNCT
bjp-23565	183	46	vogel	vogel	NOUN
bjp-23565	183	47	vg	vg	PROPN
bjp-23565	183	48	,	,	PUNCT
bjp-23565	183	49	visscher	visscher	PROPN
bjp-23565	183	50	dw	dw	PROPN
bjp-23565	183	51	,	,	PUNCT
bjp-23565	183	52	yothers	yother	VERB
bjp-23565	183	53	g	g	PROPN
bjp-23565	183	54	,	,	PUNCT
bjp-23565	183	55	jenkins	jenkins	PROPN
bjp-23565	183	56	rb	rb	PROPN
bjp-23565	183	57	,	,	PUNCT
bjp-23565	183	58	brown	brown	ADJ
bjp-23565	183	59	am	am	NOUN
bjp-23565	183	60	,	,	PUNCT
bjp-23565	183	61	dakhil	dakhil	VERB
bjp-23565	183	62	sr	sr	PROPN
bjp-23565	183	63	,	,	PUNCT
bjp-23565	183	64	mamounas	mamounas	PROPN
bjp-23565	183	65	ep	ep	PROPN
bjp-23565	183	66	,	,	PUNCT
bjp-23565	183	67	lingle	lingle	PROPN
bjp-23565	183	68	wl	wl	PROPN
bjp-23565	183	69	,	,	PUNCT
bjp-23565	183	70	klein	klein	PROPN
bjp-23565	183	71	pm	pm	PROPN
bjp-23565	183	72	,	,	PUNCT
bjp-23565	183	73	ingle	ingle	PROPN
bjp-23565	183	74	jn	jn	PROPN
bjp-23565	183	75	,	,	PUNCT
bjp-23565	183	76	wolmark	wolmark	PROPN
bjp-23565	183	77	bangladesh	bangladesh	PROPN
bjp-23565	183	78	j	j	PROPN
bjp-23565	183	79	pharmacol	pharmacol	PROPN
bjp-23565	183	80	2015	2015	NUM
bjp-23565	183	81	;	;	PUNCT
bjp-23565	183	82	10	10	NUM
bjp-23565	183	83	:	:	PUNCT
bjp-23565	183	84	799	799	NUM
bjp-23565	183	85	-	-	SYM
bjp-23565	183	86	806	806	NUM
bjp-23565	183	87	805	805	NUM
bjp-23565	183	88	n.	n.	NOUN
bjp-23565	183	89	trastuzumab	trastuzumab	NOUN
bjp-23565	183	90	plus	plus	CCONJ
bjp-23565	183	91	adjuvant	adjuvant	ADJ
bjp-23565	183	92	chemotherapy	chemotherapy	NOUN
bjp-23565	183	93	for	for	ADP
bjp-23565	183	94	operable	operable	ADJ
bjp-23565	183	95	her2	her2	PROPN
bjp-23565	183	96	-	-	PUNCT
bjp-23565	183	97	positive	positive	ADJ
bjp-23565	183	98	breast	breast	NOUN
bjp-23565	183	99	cancer	cancer	NOUN
bjp-23565	183	100	.	.	PUNCT
bjp-23565	184	1	n	n	PROPN
bjp-23565	184	2	engl	engl	PROPN
bjp-23565	184	3	j	j	PROPN
bjp-23565	184	4	med	med	PROPN
bjp-23565	184	5	.	.	PUNCT
bjp-23565	184	6	2005	2005	NUM
bjp-23565	184	7	;	;	PUNCT
bjp-23565	184	8	353	353	NUM
bjp-23565	184	9	:	:	SYM
bjp-23565	184	10	1673	1673	NUM
bjp-23565	184	11	–	–	PUNCT
bjp-23565	184	12	84	84	NUM
bjp-23565	184	13	.	.	PUNCT
bjp-23565	185	1	rowinsky	rowinsky	PROPN
bjp-23565	185	2	ek	ek	PROPN
bjp-23565	185	3	,	,	PUNCT
bjp-23565	185	4	cazenave	cazenave	NOUN
bjp-23565	185	5	la	la	NOUN
bjp-23565	185	6	,	,	PUNCT
bjp-23565	185	7	donehower	donehower	PROPN
bjp-23565	185	8	rc	rc	PROPN
bjp-23565	185	9	.	.	PROPN
bjp-23565	185	10	taxol	taxol	PROPN
bjp-23565	185	11	:	:	PUNCT
bjp-23565	185	12	a	a	DET
bjp-23565	185	13	novel	novel	ADJ
bjp-23565	185	14	investigational	investigational	ADJ
bjp-23565	185	15	antimicrotubule	antimicrotubule	NOUN
bjp-23565	185	16	agent	agent	NOUN
bjp-23565	185	17	.	.	PUNCT
bjp-23565	186	1	j	j	PROPN
bjp-23565	186	2	natl	natl	PROPN
bjp-23565	186	3	cancer	cancer	PROPN
bjp-23565	186	4	inst	inst	PROPN
bjp-23565	186	5	.	.	PUNCT
bjp-23565	186	6	1990	1990	NUM
bjp-23565	186	7	;	;	PUNCT
bjp-23565	186	8	82	82	NUM
bjp-23565	186	9	:	:	SYM
bjp-23565	186	10	1247	1247	NUM
bjp-23565	186	11	-	-	SYM
bjp-23565	186	12	59	59	NUM
bjp-23565	186	13	.	.	PUNCT
bjp-23565	187	1	sachdev	sachdev	PROPN
bjp-23565	187	2	d	d	PROPN
bjp-23565	187	3	,	,	PUNCT
bjp-23565	187	4	hartell	hartell	INTJ
bjp-23565	187	5	js	js	PROPN
bjp-23565	187	6	,	,	PUNCT
bjp-23565	187	7	lee	lee	PROPN
bjp-23565	187	8	av	av	PROPN
bjp-23565	187	9	,	,	PUNCT
bjp-23565	187	10	zhang	zhang	PROPN
bjp-23565	187	11	x	x	PROPN
bjp-23565	187	12	,	,	PUNCT
bjp-23565	187	13	yee	yee	PROPN
bjp-23565	187	14	d.	d.	PROPN
bjp-23565	187	15	a	a	DET
bjp-23565	187	16	dominant	dominant	ADJ
bjp-23565	187	17	negative	negative	ADJ
bjp-23565	187	18	type	type	NOUN
bjp-23565	187	19	i	i	PRON
bjp-23565	187	20	insulin	insulin	NOUN
bjp-23565	187	21	-	-	PUNCT
bjp-23565	187	22	like	like	ADJ
bjp-23565	187	23	growth	growth	NOUN
bjp-23565	187	24	factor	factor	NOUN
bjp-23565	187	25	receptor	receptor	NOUN
bjp-23565	187	26	inhibits	inhibit	VERB
bjp-23565	187	27	metastasis	metastasis	NOUN
bjp-23565	187	28	of	of	ADP
bjp-23565	187	29	human	human	ADJ
bjp-23565	187	30	cancer	cancer	NOUN
bjp-23565	187	31	cells	cell	NOUN
bjp-23565	187	32	.	.	PUNCT
bjp-23565	188	1	j	j	PROPN
bjp-23565	188	2	biol	biol	PROPN
bjp-23565	188	3	chem	chem	NOUN
bjp-23565	188	4	.	.	PUNCT
bjp-23565	189	1	2004	2004	NUM
bjp-23565	189	2	;	;	PUNCT
bjp-23565	190	1	279	279	NUM
bjp-23565	190	2	:	:	PUNCT
bjp-23565	190	3	5017–24	5017–24	NUM
bjp-23565	190	4	.	.	PUNCT
bjp-23565	191	1	sarfstein	sarfstein	NOUN
bjp-23565	191	2	r	r	NOUN
bjp-23565	191	3	,	,	PUNCT
bjp-23565	191	4	pasmanik	pasmanik	VERB
bjp-23565	191	5	-	-	NOUN
bjp-23565	191	6	chor	chor	NOUN
bjp-23565	191	7	m	m	PROPN
bjp-23565	191	8	,	,	PUNCT
bjp-23565	191	9	yeheskel	yeheskel	NOUN
bjp-23565	191	10	a	a	PRON
bjp-23565	191	11	,	,	PUNCT
bjp-23565	191	12	edry	edry	ADJ
bjp-23565	191	13	l	l	PROPN
bjp-23565	191	14	,	,	PUNCT
bjp-23565	191	15	shomron	shomron	PROPN
bjp-23565	191	16	n	n	PROPN
bjp-23565	191	17	,	,	PUNCT
bjp-23565	191	18	warman	warman	PROPN
bjp-23565	191	19	n	n	CCONJ
bjp-23565	191	20	,	,	PUNCT
bjp-23565	191	21	wertheimer	wertheimer	X
bjp-23565	191	22	e	e	NOUN
bjp-23565	191	23	,	,	PUNCT
bjp-23565	191	24	maor	maor	PROPN
bjp-23565	191	25	s	s	PROPN
bjp-23565	191	26	,	,	PUNCT
bjp-23565	191	27	shochat	shochat	ADJ
bjp-23565	191	28	l	l	NOUN
bjp-23565	191	29	,	,	PUNCT
bjp-23565	191	30	werner	werner	PROPN
bjp-23565	191	31	h.	h.	PROPN
bjp-23565	191	32	insulin	insulin	PROPN
bjp-23565	191	33	-	-	PUNCT
bjp-23565	191	34	like	like	ADJ
bjp-23565	191	35	growth	growth	NOUN
bjp-23565	191	36	factor	factor	NOUN
bjp-23565	191	37	-	-	PUNCT
bjp-23565	191	38	i	i	PRON
bjp-23565	191	39	receptor	receptor	NOUN
bjp-23565	191	40	(	(	PUNCT
bjp-23565	191	41	igf	igf	PROPN
bjp-23565	191	42	-	-	ADJ
bjp-23565	191	43	ir	ir	NOUN
bjp-23565	191	44	)	)	PUNCT
bjp-23565	191	45	translocates	translocate	NOUN
bjp-23565	191	46	to	to	ADP
bjp-23565	191	47	nucleus	nucleus	NOUN
bjp-23565	191	48	and	and	CCONJ
bjp-23565	191	49	autoregulates	autoregulates	PROPN
bjp-23565	191	50	igf	igf	PROPN
bjp-23565	191	51	-	-	ADJ
bjp-23565	191	52	ir	ir	ADJ
bjp-23565	191	53	gene	gene	NOUN
bjp-23565	191	54	expression	expression	NOUN
bjp-23565	191	55	in	in	ADP
bjp-23565	191	56	breast	breast	NOUN
bjp-23565	191	57	cancer	cancer	NOUN
bjp-23565	191	58	cells	cell	NOUN
bjp-23565	191	59	.	.	PUNCT
bjp-23565	192	1	j	j	PROPN
bjp-23565	192	2	biol	biol	PROPN
bjp-23565	192	3	chem	chem	NOUN
bjp-23565	192	4	.	.	PUNCT
bjp-23565	193	1	2012	2012	NUM
bjp-23565	193	2	;	;	PUNCT
bjp-23565	193	3	287	287	NUM
bjp-23565	193	4	:	:	PUNCT
bjp-23565	194	1	2766–76	2766–76	NUM
bjp-23565	194	2	.	.	PUNCT
bjp-23565	195	1	slamon	slamon	PROPN
bjp-23565	195	2	dj	dj	PROPN
bjp-23565	195	3	,	,	PUNCT
bjp-23565	195	4	leyland	leyland	PROPN
bjp-23565	195	5	-	-	PUNCT
bjp-23565	195	6	jones	jones	PROPN
bjp-23565	195	7	b	b	PROPN
bjp-23565	195	8	,	,	PUNCT
bjp-23565	195	9	shak	shak	PROPN
bjp-23565	195	10	s	s	PROPN
bjp-23565	195	11	,	,	PUNCT
bjp-23565	195	12	fuchs	fuchs	PROPN
bjp-23565	195	13	h	h	PROPN
bjp-23565	195	14	,	,	PUNCT
bjp-23565	195	15	paton	paton	PROPN
bjp-23565	195	16	v	v	PROPN
bjp-23565	195	17	,	,	PUNCT
bjp-23565	195	18	bajamonde	bajamonde	VERB
bjp-23565	195	19	a	a	PRON
bjp-23565	195	20	,	,	PUNCT
bjp-23565	195	21	fleming	fleming	PROPN
bjp-23565	195	22	t	t	PROPN
bjp-23565	195	23	,	,	PUNCT
bjp-23565	195	24	eiermann	eiermann	PROPN
bjp-23565	195	25	w	w	PROPN
bjp-23565	195	26	,	,	PUNCT
bjp-23565	195	27	wolter	wolter	PROPN
bjp-23565	195	28	j	j	PROPN
bjp-23565	195	29	,	,	PUNCT
bjp-23565	195	30	pegram	pegram	PROPN
bjp-23565	195	31	m	m	PROPN
bjp-23565	195	32	,	,	PUNCT
bjp-23565	195	33	baselga	baselga	PROPN
bjp-23565	195	34	j	j	PROPN
bjp-23565	195	35	,	,	PUNCT
bjp-23565	195	36	norton	norton	PROPN
bjp-23565	195	37	l.	l.	PROPN
bjp-23565	195	38	use	use	NOUN
bjp-23565	195	39	of	of	ADP
bjp-23565	195	40	chemotherapy	chemotherapy	NOUN
bjp-23565	195	41	plus	plus	CCONJ
bjp-23565	195	42	a	a	DET
bjp-23565	195	43	monoclonal	monoclonal	NOUN
bjp-23565	195	44	antibody	antibody	NOUN
bjp-23565	195	45	against	against	ADP
bjp-23565	195	46	her2	her2	PROPN
bjp-23565	195	47	for	for	ADP
bjp-23565	195	48	metastatic	metastatic	ADJ
bjp-23565	195	49	breast	breast	NOUN
bjp-23565	195	50	cancer	cancer	NOUN
bjp-23565	195	51	that	that	PRON
bjp-23565	195	52	overexpresses	overexpresse	VERB
bjp-23565	195	53	her2	her2	VERB
bjp-23565	195	54	.	.	PUNCT
bjp-23565	196	1	n	n	PROPN
bjp-23565	196	2	engl	engl	PROPN
bjp-23565	196	3	j	j	PROPN
bjp-23565	196	4	med	med	PROPN
bjp-23565	196	5	.	.	PUNCT
bjp-23565	196	6	2001	2001	NUM
bjp-23565	196	7	;	;	PUNCT
bjp-23565	196	8	344	344	NUM
bjp-23565	196	9	:	:	PUNCT
bjp-23565	196	10	783–92	783–92	NOUN
bjp-23565	196	11	.	.	PUNCT
bjp-23565	197	1	ullrich	ullrich	PROPN
bjp-23565	197	2	a	a	DET
bjp-23565	197	3	,	,	PUNCT
bjp-23565	197	4	gray	gray	ADJ
bjp-23565	197	5	a	a	X
bjp-23565	197	6	,	,	PUNCT
bjp-23565	197	7	tam	tam	PROPN
bjp-23565	197	8	aw	aw	PROPN
bjp-23565	197	9	,	,	PUNCT
bjp-23565	197	10	yang	yang	PROPN
bjp-23565	197	11	-	-	PUNCT
bjp-23565	197	12	feng	feng	PROPN
bjp-23565	197	13	t	t	PROPN
bjp-23565	197	14	,	,	PUNCT
bjp-23565	197	15	tsubokawa	tsubokawa	PROPN
bjp-23565	197	16	m	m	PROPN
bjp-23565	197	17	,	,	PUNCT
bjp-23565	197	18	collins	collins	PROPN
bjp-23565	197	19	c	c	PROPN
bjp-23565	197	20	,	,	PUNCT
bjp-23565	197	21	henzel	henzel	PROPN
bjp-23565	197	22	w	w	PROPN
bjp-23565	197	23	,	,	PUNCT
bjp-23565	197	24	le	le	PROPN
bjp-23565	197	25	bon	bon	PROPN
bjp-23565	197	26	t	t	PROPN
bjp-23565	197	27	,	,	PUNCT
bjp-23565	197	28	kathuria	kathuria	PROPN
bjp-23565	197	29	s	s	PROPN
bjp-23565	197	30	,	,	PUNCT
bjp-23565	197	31	chen	chen	PROPN
bjp-23565	197	32	e.	e.	PROPN
bjp-23565	197	33	insulinlike	insulinlike	PROPN
bjp-23565	197	34	growth	growth	NOUN
bjp-23565	197	35	factor	factor	NOUN
bjp-23565	197	36	i	i	PRON
bjp-23565	197	37	receptor	receptor	VERB
bjp-23565	197	38	primary	primary	ADJ
bjp-23565	197	39	structure	structure	NOUN
bjp-23565	197	40	:	:	PUNCT
bjp-23565	197	41	comparison	comparison	NOUN
bjp-23565	197	42	with	with	ADP
bjp-23565	197	43	insulin	insulin	NOUN
bjp-23565	197	44	receptor	receptor	NOUN
bjp-23565	197	45	suggests	suggest	VERB
bjp-23565	197	46	structural	structural	ADJ
bjp-23565	197	47	determinants	determinant	NOUN
bjp-23565	197	48	that	that	PRON
bjp-23565	197	49	define	define	VERB
bjp-23565	197	50	functional	functional	ADJ
bjp-23565	197	51	specificity	specificity	NOUN
bjp-23565	197	52	.	.	PUNCT
bjp-23565	198	1	embo	embo	PROPN
bjp-23565	198	2	j.	j.	PROPN
bjp-23565	198	3	1986	1986	NUM
bjp-23565	198	4	;	;	PUNCT
bjp-23565	198	5	5	5	NUM
bjp-23565	198	6	:	:	SYM
bjp-23565	198	7	2503–12	2503–12	NUM
bjp-23565	198	8	.	.	PUNCT
bjp-23565	199	1	author	author	NOUN
bjp-23565	199	2	info	info	PROPN
bjp-23565	199	3	rui	rui	PROPN
bjp-23565	199	4	yu	yu	PROPN
bjp-23565	199	5	(	(	PUNCT
bjp-23565	199	6	principal	principal	ADJ
bjp-23565	199	7	contact	contact	NOUN
bjp-23565	199	8	)	)	PUNCT
bjp-23565	199	9	;	;	PUNCT
bjp-23565	199	10	e	e	X
bjp-23565	199	11	-	-	NOUN
bjp-23565	199	12	mail	mail	NOUN
bjp-23565	199	13	:	:	PUNCT
bjp-23565	199	14	yuruiyr@hotmail.com	yuruiyr@hotmail.com	X
bjp-23565	199	15	;	;	PUNCT
bjp-23565	199	16	tel	tel	PROPN
bjp-23565	199	17	.	.	PROPN
bjp-23565	199	18	&	&	CCONJ
bjp-23565	199	19	fax	fax	PROPN
bjp-23565	199	20	:	:	PUNCT
bjp-23565	199	21	0086	0086	NUM
bjp-23565	199	22	-	-	PUNCT
bjp-23565	199	23	574	574	NUM
bjp-23565	199	24	-	-	PUNCT
bjp-23565	199	25	87600674	87600674	NUM
bjp-23565	199	26	806	806	NUM
bjp-23565	199	27	bangladesh	bangladesh	PROPN
bjp-23565	199	28	j	j	PROPN
bjp-23565	199	29	pharmacol	pharmacol	PROPN
bjp-23565	199	30	2015	2015	NUM
bjp-23565	199	31	;	;	PUNCT
bjp-23565	199	32	10	10	NUM
bjp-23565	199	33	:	:	PUNCT
bjp-23565	199	34	799	799	NUM
bjp-23565	199	35	-	-	SYM
bjp-23565	199	36	806	806	NUM
bjp-23565	199	37	dateprinted	dateprinte	VERB
bjp-23565	199	38	:	:	PUNCT
bjp-23565	199	39	this	this	DET
bjp-23565	199	40	article	article	NOUN
bjp-23565	199	41	was	be	AUX
bjp-23565	199	42	downloaded	download	VERB
bjp-23565	199	43	by	by	ADP
bjp-23565	199	44	you	you	PRON
bjp-23565	199	45	on	on	ADP
bjp-23565	199	46	:	:	PUNCT
bjp-23565	199	47	sep	sep	PROPN
bjp-23565	199	48	12	12	NUM
bjp-23565	199	49	,	,	PUNCT
bjp-23565	199	50	2018	2018	NUM