id	sid	tid	token	lemma	pos
bjp-23604	1	1	introduction	introduction	NOUN
bjp-23604	1	2	urinary	urinary	ADJ
bjp-23604	1	3	tract	tract	NOUN
bjp-23604	1	4	infections	infection	NOUN
bjp-23604	1	5	are	be	AUX
bjp-23604	1	6	among	among	ADP
bjp-23604	1	7	the	the	DET
bjp-23604	1	8	most	most	ADV
bjp-23604	1	9	common	common	ADJ
bjp-23604	1	10	community	community	NOUN
bjp-23604	1	11	bacterial	bacterial	ADJ
bjp-23604	1	12	infections	infection	NOUN
bjp-23604	1	13	.	.	PUNCT
bjp-23604	2	1	urinary	urinary	ADJ
bjp-23604	2	2	tract	tract	NOUN
bjp-23604	2	3	infections	infection	NOUN
bjp-23604	2	4	with	with	ADP
bjp-23604	2	5	involvement	involvement	NOUN
bjp-23604	2	6	of	of	ADP
bjp-23604	2	7	upper	upper	ADJ
bjp-23604	2	8	urinary	urinary	ADJ
bjp-23604	2	9	tract	tract	NOUN
bjp-23604	2	10	portions	portion	NOUN
bjp-23604	2	11	,	,	PUNCT
bjp-23604	2	12	occurring	occur	VERB
bjp-23604	2	13	in	in	ADP
bjp-23604	2	14	patients	patient	NOUN
bjp-23604	2	15	with	with	ADP
bjp-23604	2	16	underlying	underlie	VERB
bjp-23604	2	17	diseases	disease	NOUN
bjp-23604	2	18	(	(	PUNCT
bjp-23604	2	19	diabetes	diabete	NOUN
bjp-23604	2	20	mellitus	mellitus	NOUN
bjp-23604	2	21	,	,	PUNCT
bjp-23604	2	22	immunosuppression	immunosuppression	NOUN
bjp-23604	2	23	)	)	PUNCT
bjp-23604	2	24	(	(	PUNCT
bjp-23604	2	25	krcmery	krcmery	PROPN
bjp-23604	2	26	and	and	CCONJ
bjp-23604	2	27	naber	naber	PROPN
bjp-23604	2	28	,	,	PUNCT
bjp-23604	2	29	1999	1999	NUM
bjp-23604	2	30	)	)	PUNCT
bjp-23604	2	31	or	or	CCONJ
bjp-23604	2	32	structural	structural	ADJ
bjp-23604	2	33	abnormalities	abnormality	NOUN
bjp-23604	2	34	of	of	ADP
bjp-23604	2	35	urinary	urinary	ADJ
bjp-23604	2	36	tract	tract	NOUN
bjp-23604	2	37	are	be	AUX
bjp-23604	2	38	classified	classify	VERB
bjp-23604	2	39	as	as	ADP
bjp-23604	2	40	complicated	complicated	ADJ
bjp-23604	2	41	urinary	urinary	ADJ
bjp-23604	2	42	tract	tract	NOUN
bjp-23604	2	43	infections	infection	NOUN
bjp-23604	2	44	(	(	PUNCT
bjp-23604	2	45	nicolle	nicolle	NOUN
bjp-23604	2	46	,	,	PUNCT
bjp-23604	2	47	2005	2005	NUM
bjp-23604	2	48	)	)	PUNCT
bjp-23604	2	49	.	.	PUNCT
bjp-23604	3	1	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	3	2	and	and	CCONJ
bjp-23604	3	3	other	other	ADJ
bjp-23604	3	4	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	3	5	have	have	AUX
bjp-23604	3	6	become	become	VERB
bjp-23604	3	7	a	a	DET
bjp-23604	3	8	popular	popular	ADJ
bjp-23604	3	9	treatment	treatment	NOUN
bjp-23604	3	10	option	option	NOUN
bjp-23604	3	11	for	for	ADP
bjp-23604	3	12	patients	patient	NOUN
bjp-23604	3	13	with	with	ADP
bjp-23604	3	14	complicated	complicated	ADJ
bjp-23604	3	15	urinary	urinary	ADJ
bjp-23604	3	16	tract	tract	NOUN
bjp-23604	3	17	infections	infection	NOUN
bjp-23604	3	18	in	in	ADP
bjp-23604	3	19	areas	area	NOUN
bjp-23604	3	20	with	with	ADP
bjp-23604	3	21	higher	high	ADJ
bjp-23604	3	22	rates	rate	NOUN
bjp-23604	3	23	of	of	ADP
bjp-23604	3	24	resistance	resistance	NOUN
bjp-23604	3	25	to	to	ADP
bjp-23604	3	26	traditionally	traditionally	ADV
bjp-23604	3	27	used	use	VERB
bjp-23604	3	28	antibacterial	antibacterial	ADJ
bjp-23604	3	29	agents	agent	NOUN
bjp-23604	3	30	such	such	ADJ
bjp-23604	3	31	as	as	ADP
bjp-23604	3	32	trimethoprimsulfamethoxazole	trimethoprimsulfamethoxazole	NOUN
bjp-23604	3	33	and	and	CCONJ
bjp-23604	3	34	aminopenicillins	aminopenicillin	NOUN
bjp-23604	3	35	(	(	PUNCT
bjp-23604	3	36	van	van	PROPN
bjp-23604	3	37	bambeke	bambeke	PROPN
bjp-23604	3	38	et	et	PROPN
bjp-23604	3	39	al	al	PROPN
bjp-23604	3	40	.	.	PROPN
bjp-23604	3	41	,	,	PUNCT
bjp-23604	3	42	2005	2005	NUM
bjp-23604	3	43	;	;	PUNCT
bjp-23604	3	44	finch	finch	NOUN
bjp-23604	3	45	,	,	PUNCT
bjp-23604	3	46	2000	2000	NUM
bjp-23604	3	47	)	)	PUNCT
bjp-23604	3	48	.	.	PUNCT
bjp-23604	4	1	however	however	ADV
bjp-23604	4	2	,	,	PUNCT
bjp-23604	4	3	excessive	excessive	ADJ
bjp-23604	4	4	use	use	NOUN
bjp-23604	4	5	of	of	ADP
bjp-23604	4	6	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	4	7	that	that	PRON
bjp-23604	4	8	has	have	AUX
bjp-23604	4	9	led	lead	VERB
bjp-23604	4	10	to	to	ADP
bjp-23604	4	11	a	a	DET
bjp-23604	4	12	considerable	considerable	ADJ
bjp-23604	4	13	and	and	CCONJ
bjp-23604	4	14	worrying	worrying	ADJ
bjp-23604	4	15	increase	increase	NOUN
bjp-23604	4	16	in	in	ADP
bjp-23604	4	17	the	the	DET
bjp-23604	4	18	rate	rate	NOUN
bjp-23604	4	19	of	of	ADP
bjp-23604	4	20	resistant	resistant	ADJ
bjp-23604	4	21	isolates	isolate	NOUN
bjp-23604	4	22	(	(	PUNCT
bjp-23604	4	23	daoud	daoud	PROPN
bjp-23604	4	24	et	et	PROPN
bjp-23604	4	25	al	al	PROPN
bjp-23604	4	26	.	.	PROPN
bjp-23604	4	27	,	,	PUNCT
bjp-23604	4	28	2014	2014	NUM
bjp-23604	4	29	)	)	PUNCT
bjp-23604	4	30	which	which	PRON
bjp-23604	4	31	raises	raise	VERB
bjp-23604	4	32	a	a	DET
bjp-23604	4	33	question	question	NOUN
bjp-23604	4	34	of	of	ADP
bjp-23604	4	35	adequacy	adequacy	NOUN
bjp-23604	4	36	of	of	ADP
bjp-23604	4	37	current	current	ADJ
bjp-23604	4	38	dosing	dosing	ADJ
bjp-23604	4	39	strategies	strategy	NOUN
bjp-23604	4	40	.	.	PUNCT
bjp-23604	5	1	the	the	DET
bjp-23604	5	2	outcome	outcome	NOUN
bjp-23604	5	3	of	of	ADP
bjp-23604	5	4	antibiotic	antibiotic	ADJ
bjp-23604	5	5	treatment	treatment	NOUN
bjp-23604	5	6	depends	depend	VERB
bjp-23604	5	7	on	on	ADP
bjp-23604	5	8	several	several	ADJ
bjp-23604	5	9	complex	complex	ADJ
bjp-23604	5	10	interactions	interaction	NOUN
bjp-23604	5	11	between	between	ADP
bjp-23604	5	12	the	the	DET
bjp-23604	5	13	infectious	infectious	ADJ
bjp-23604	5	14	agent	agent	NOUN
bjp-23604	5	15	,	,	PUNCT
bjp-23604	5	16	antimicrobial	antimicrobial	ADJ
bjp-23604	5	17	drug	drug	NOUN
bjp-23604	5	18	and	and	CCONJ
bjp-23604	5	19	host	host	NOUN
bjp-23604	5	20	defense	defense	NOUN
bjp-23604	5	21	mechanisms	mechanism	NOUN
bjp-23604	5	22	,	,	PUNCT
bjp-23604	5	23	and	and	CCONJ
bjp-23604	5	24	treatment	treatment	NOUN
bjp-23604	5	25	outcome	outcome	NOUN
bjp-23604	5	26	shows	show	VERB
bjp-23604	5	27	high	high	ADJ
bjp-23604	5	28	variability	variability	NOUN
bjp-23604	5	29	of	of	ADP
bjp-23604	5	30	the	the	DET
bjp-23604	5	31	dose	dose	NOUN
bjp-23604	5	32	-	-	PUNCT
bjp-23604	5	33	response	response	NOUN
bjp-23604	5	34	relationship	relationship	NOUN
bjp-23604	5	35	(	(	PUNCT
bjp-23604	5	36	jacobs	jacobs	PROPN
bjp-23604	5	37	,	,	PUNCT
bjp-23604	5	38	2001	2001	NUM
bjp-23604	5	39	;	;	PUNCT
bjp-23604	5	40	wilspelwey	wilspelwey	PROPN
bjp-23604	5	41	,	,	PUNCT
bjp-23604	5	42	2005	2005	NUM
bjp-23604	5	43	)	)	PUNCT
bjp-23604	5	44	.	.	PUNCT
bjp-23604	6	1	for	for	ADP
bjp-23604	6	2	the	the	DET
bjp-23604	6	3	optimal	optimal	ADJ
bjp-23604	6	4	clinical	clinical	ADJ
bjp-23604	6	5	outcome	outcome	NOUN
bjp-23604	6	6	,	,	PUNCT
bjp-23604	6	7	high	high	ADJ
bjp-23604	6	8	concentrations	concentration	NOUN
bjp-23604	6	9	at	at	ADP
bjp-23604	6	10	the	the	DET
bjp-23604	6	11	site	site	NOUN
bjp-23604	6	12	of	of	ADP
bjp-23604	6	13	the	the	DET
bjp-23604	6	14	infection	infection	NOUN
bjp-23604	6	15	are	be	AUX
bjp-23604	6	16	critical	critical	ADJ
bjp-23604	6	17	for	for	ADP
bjp-23604	6	18	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	6	19	(	(	PUNCT
bjp-23604	6	20	drussano	drussano	NOUN
bjp-23604	6	21	et	et	PROPN
bjp-23604	6	22	al	al	PROPN
bjp-23604	6	23	.	.	PROPN
bjp-23604	6	24	,	,	PUNCT
bjp-23604	6	25	2004	2004	NUM
bjp-23604	6	26	)	)	PUNCT
bjp-23604	6	27	.	.	PUNCT
bjp-23604	7	1	this	this	PRON
bjp-23604	7	2	is	be	AUX
bjp-23604	7	3	reflected	reflect	VERB
bjp-23604	7	4	in	in	ADP
bjp-23604	7	5	the	the	DET
bjp-23604	7	6	peak	peak	NOUN
bjp-23604	7	7	concentration	concentration	NOUN
bjp-23604	7	8	and	and	CCONJ
bjp-23604	7	9	area	area	NOUN
bjp-23604	7	10	under	under	ADP
bjp-23604	7	11	the	the	DET
bjp-23604	7	12	concentration	concentration	NOUN
bjp-23604	7	13	-	-	PUNCT
bjp-23604	7	14	time	time	NOUN
bjp-23604	7	15	curve	curve	NOUN
bjp-23604	7	16	being	be	AUX
bjp-23604	7	17	the	the	DET
bjp-23604	7	18	main	main	ADJ
bjp-23604	7	19	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	7	20	parameters	parameter	NOUN
bjp-23604	7	21	taken	take	VERB
bjp-23604	7	22	into	into	ADP
bjp-23604	7	23	account	account	NOUN
bjp-23604	7	24	when	when	SCONJ
bjp-23604	7	25	discussing	discuss	VERB
bjp-23604	7	26	efficacy	efficacy	NOUN
bjp-23604	7	27	indices	index	NOUN
bjp-23604	7	28	for	for	ADP
bjp-23604	7	29	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	7	30	(	(	PUNCT
bjp-23604	7	31	mueller	mueller	PROPN
bjp-23604	7	32	et	et	PROPN
bjp-23604	7	33	al	al	PROPN
bjp-23604	7	34	.	.	PROPN
bjp-23604	7	35	,	,	PUNCT
bjp-23604	7	36	2004	2004	NUM
bjp-23604	7	37	)	)	PUNCT
bjp-23604	7	38	.	.	PUNCT
bjp-23604	8	1	in	in	ADP
bjp-23604	8	2	past	past	ADJ
bjp-23604	8	3	decades	decade	NOUN
bjp-23604	8	4	,	,	PUNCT
bjp-23604	8	5	the	the	DET
bjp-23604	8	6	importance	importance	NOUN
bjp-23604	8	7	of	of	ADP
bjp-23604	8	8	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	8	9	parametersmainly	parametersmainly	ADJ
bjp-23604	8	10	mechanism	mechanism	NOUN
bjp-23604	8	11	of	of	ADP
bjp-23604	8	12	bacterial	bacterial	ADJ
bjp-23604	8	13	eradication	eradication	NOUN
bjp-23604	8	14	and	and	CCONJ
bjp-23604	8	15	postantibiotic	postantibiotic	ADJ
bjp-23604	8	16	effect	effect	NOUN
bjp-23604	8	17	has	have	AUX
bjp-23604	8	18	also	also	ADV
bjp-23604	8	19	been	be	AUX
bjp-23604	8	20	recognized	recognize	VERB
bjp-23604	8	21	and	and	CCONJ
bjp-23604	8	22	an	an	DET
bjp-23604	8	23	answer	answer	NOUN
bjp-23604	8	24	to	to	ADP
bjp-23604	8	25	complexity	complexity	NOUN
bjp-23604	8	26	of	of	ADP
bjp-23604	8	27	antibioticmicroorganism	antibioticmicroorganism	NOUN
bjp-23604	8	28	interaction	interaction	NOUN
bjp-23604	8	29	has	have	AUX
bjp-23604	8	30	been	be	AUX
bjp-23604	8	31	found	find	VERB
bjp-23604	8	32	in	in	ADP
bjp-23604	8	33	a	a	DET
bjp-23604	8	34	quantia	quantia	NOUN
bjp-23604	8	35	journal	journal	NOUN
bjp-23604	8	36	of	of	ADP
bjp-23604	8	37	the	the	DET
bjp-23604	8	38	bangladesh	bangladesh	NOUN
bjp-23604	8	39	pharmacological	pharmacological	ADJ
bjp-23604	8	40	society	society	NOUN
bjp-23604	8	41	(	(	PUNCT
bjp-23604	8	42	bdps	bdps	NOUN
bjp-23604	8	43	)	)	PUNCT
bjp-23604	8	44	bangladesh	bangladesh	PROPN
bjp-23604	8	45	j	j	PROPN
bjp-23604	8	46	pharmacol	pharmacol	PROPN
bjp-23604	8	47	2015	2015	NUM
bjp-23604	8	48	;	;	PUNCT
bjp-23604	8	49	10	10	NUM
bjp-23604	8	50	:	:	SYM
bjp-23604	8	51	621	621	NUM
bjp-23604	8	52	-	-	SYM
bjp-23604	8	53	626	626	NUM
bjp-23604	8	54	journal	journal	NOUN
bjp-23604	8	55	homepage	homepage	NOUN
bjp-23604	8	56	:	:	PUNCT
bjp-23604	8	57	www.banglajol.info	www.banglajol.info	PROPN
bjp-23604	8	58	abstracted	abstract	VERB
bjp-23604	8	59	/	/	SYM
bjp-23604	8	60	indexed	index	VERB
bjp-23604	8	61	in	in	ADP
bjp-23604	8	62	academic	academic	ADJ
bjp-23604	8	63	search	search	NOUN
bjp-23604	8	64	complete	complete	ADJ
bjp-23604	8	65	,	,	PUNCT
bjp-23604	8	66	agroforestry	agroforestry	NOUN
bjp-23604	8	67	abstracts	abstract	NOUN
bjp-23604	8	68	,	,	PUNCT
bjp-23604	8	69	asia	asia	PROPN
bjp-23604	8	70	journals	journal	NOUN
bjp-23604	8	71	online	online	ADV
bjp-23604	8	72	,	,	PUNCT
bjp-23604	8	73	bangladesh	bangladesh	NOUN
bjp-23604	8	74	journals	journal	NOUN
bjp-23604	8	75	online	online	ADV
bjp-23604	8	76	,	,	PUNCT
bjp-23604	8	77	biological	biological	ADJ
bjp-23604	8	78	abstracts	abstract	NOUN
bjp-23604	8	79	,	,	PUNCT
bjp-23604	8	80	biosis	biosis	NOUN
bjp-23604	8	81	previews	preview	NOUN
bjp-23604	8	82	,	,	PUNCT
bjp-23604	8	83	cab	cab	NOUN
bjp-23604	8	84	abstracts	abstract	NOUN
bjp-23604	8	85	,	,	PUNCT
bjp-23604	8	86	current	current	ADJ
bjp-23604	8	87	abstracts	abstract	NOUN
bjp-23604	8	88	,	,	PUNCT
bjp-23604	8	89	directory	directory	NOUN
bjp-23604	8	90	of	of	ADP
bjp-23604	8	91	open	open	ADJ
bjp-23604	8	92	access	access	NOUN
bjp-23604	8	93	journals	journal	NOUN
bjp-23604	8	94	,	,	PUNCT
bjp-23604	8	95	embase	embase	NOUN
bjp-23604	8	96	/	/	SYM
bjp-23604	8	97	excerpta	excerpta	NOUN
bjp-23604	8	98	medica	medica	NOUN
bjp-23604	8	99	,	,	PUNCT
bjp-23604	8	100	google	google	PROPN
bjp-23604	8	101	scholar	scholar	NOUN
bjp-23604	8	102	,	,	PUNCT
bjp-23604	8	103	hinari	hinari	X
bjp-23604	8	104	(	(	PUNCT
bjp-23604	8	105	who	who	PRON
bjp-23604	8	106	)	)	PUNCT
bjp-23604	8	107	,	,	PUNCT
bjp-23604	8	108	international	international	ADJ
bjp-23604	8	109	pharmaceutical	pharmaceutical	ADJ
bjp-23604	8	110	abstracts	abstract	NOUN
bjp-23604	8	111	,	,	PUNCT
bjp-23604	8	112	open	open	ADJ
bjp-23604	8	113	j	j	PROPN
bjp-23604	8	114	-	-	PUNCT
bjp-23604	8	115	gate	gate	NOUN
bjp-23604	8	116	,	,	PUNCT
bjp-23604	8	117	science	science	NOUN
bjp-23604	8	118	citation	citation	NOUN
bjp-23604	8	119	index	index	NOUN
bjp-23604	8	120	expanded	expand	VERB
bjp-23604	8	121	,	,	PUNCT
bjp-23604	8	122	scopus	scopus	NOUN
bjp-23604	8	123	and	and	CCONJ
bjp-23604	8	124	social	social	ADJ
bjp-23604	8	125	sciences	sciences	PROPN
bjp-23604	8	126	citation	citation	NOUN
bjp-23604	8	127	index	index	NOUN
bjp-23604	8	128	;	;	PUNCT
bjp-23604	8	129	issn	issn	PROPN
bjp-23604	8	130	:	:	PUNCT
bjp-23604	8	131	1991	1991	NUM
bjp-23604	8	132	-	-	PUNCT
bjp-23604	8	133	0088	0088	NUM
bjp-23604	8	134	abstract	abstract	ADJ
bjp-23604	8	135	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	8	136	is	be	AUX
bjp-23604	8	137	often	often	ADV
bjp-23604	8	138	used	use	VERB
bjp-23604	8	139	in	in	ADP
bjp-23604	8	140	treatment	treatment	NOUN
bjp-23604	8	141	of	of	ADP
bjp-23604	8	142	complicated	complicated	ADJ
bjp-23604	8	143	urinary	urinary	ADJ
bjp-23604	8	144	tract	tract	NOUN
bjp-23604	8	145	infections	infection	NOUN
bjp-23604	8	146	in	in	ADP
bjp-23604	8	147	areas	area	NOUN
bjp-23604	8	148	with	with	ADP
bjp-23604	8	149	high	high	ADJ
bjp-23604	8	150	rates	rate	NOUN
bjp-23604	8	151	of	of	ADP
bjp-23604	8	152	resistance	resistance	NOUN
bjp-23604	8	153	to	to	ADP
bjp-23604	8	154	first	first	ADJ
bjp-23604	8	155	line	line	NOUN
bjp-23604	8	156	agents	agent	NOUN
bjp-23604	8	157	.	.	PUNCT
bjp-23604	9	1	the	the	DET
bjp-23604	9	2	aim	aim	NOUN
bjp-23604	9	3	of	of	ADP
bjp-23604	9	4	this	this	DET
bjp-23604	9	5	study	study	NOUN
bjp-23604	9	6	was	be	AUX
bjp-23604	9	7	to	to	PART
bjp-23604	9	8	evaluate	evaluate	VERB
bjp-23604	9	9	efficacy	efficacy	NOUN
bjp-23604	9	10	of	of	ADP
bjp-23604	9	11	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	9	12	in	in	ADP
bjp-23604	9	13	standard	standard	ADJ
bjp-23604	9	14	dosing	dosing	ADJ
bjp-23604	9	15	regimens	regimen	NOUN
bjp-23604	9	16	in	in	ADP
bjp-23604	9	17	treatment	treatment	NOUN
bjp-23604	9	18	of	of	ADP
bjp-23604	9	19	complicated	complicated	ADJ
bjp-23604	9	20	urinary	urinary	ADJ
bjp-23604	9	21	tract	tract	NOUN
bjp-23604	9	22	infections	infection	NOUN
bjp-23604	9	23	.	.	PUNCT
bjp-23604	10	1	plasma	plasma	NOUN
bjp-23604	10	2	concentration	concentration	NOUN
bjp-23604	10	3	curves	curve	NOUN
bjp-23604	10	4	were	be	AUX
bjp-23604	10	5	simulated	simulate	VERB
bjp-23604	10	6	and	and	CCONJ
bjp-23604	10	7	minimum	minimum	ADJ
bjp-23604	10	8	inhibitory	inhibitory	ADJ
bjp-23604	10	9	concentration	concentration	NOUN
bjp-23604	10	10	(	(	PUNCT
bjp-23604	10	11	mic	mic	ADJ
bjp-23604	10	12	)	)	PUNCT
bjp-23604	10	13	and	and	CCONJ
bjp-23604	10	14	postantibiotic	postantibiotic	ADJ
bjp-23604	10	15	effect	effect	NOUN
bjp-23604	10	16	were	be	AUX
bjp-23604	10	17	determined	determine	VERB
bjp-23604	10	18	.	.	PUNCT
bjp-23604	11	1	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	11	2	mic	mic	NOUN
bjp-23604	11	3	ranged	range	VERB
bjp-23604	11	4	from	from	ADP
bjp-23604	11	5	0.0156	0.0156	NUM
bjp-23604	11	6	for	for	ADP
bjp-23604	11	7	gram	gram	NOUN
bjp-23604	11	8	-	-	PUNCT
bjp-23604	11	9	negative	negative	ADJ
bjp-23604	11	10	and	and	CCONJ
bjp-23604	11	11	to	to	ADP
bjp-23604	11	12	0.125	0.125	NUM
bjp-23604	11	13	-	-	SYM
bjp-23604	11	14	0.5	0.5	NUM
bjp-23604	11	15	µg	µg	NOUN
bjp-23604	11	16	/	/	SYM
bjp-23604	11	17	ml	ml	NOUN
bjp-23604	11	18	for	for	ADP
bjp-23604	11	19	gram	gram	NOUN
bjp-23604	11	20	-	-	PUNCT
bjp-23604	11	21	positive	positive	ADJ
bjp-23604	11	22	bacteria	bacteria	NOUN
bjp-23604	11	23	.	.	PUNCT
bjp-23604	12	1	both	both	DET
bjp-23604	12	2	dosing	dose	VERB
bjp-23604	12	3	regimens	regimen	NOUN
bjp-23604	12	4	were	be	AUX
bjp-23604	12	5	suitable	suitable	ADJ
bjp-23604	12	6	for	for	ADP
bjp-23604	12	7	eradication	eradication	NOUN
bjp-23604	12	8	of	of	ADP
bjp-23604	12	9	gram	gram	NOUN
bjp-23604	12	10	-	-	PUNCT
bjp-23604	12	11	negative	negative	ADJ
bjp-23604	12	12	bacteria	bacteria	NOUN
bjp-23604	12	13	,	,	PUNCT
bjp-23604	12	14	with	with	ADP
bjp-23604	12	15	slight	slight	ADJ
bjp-23604	12	16	supremacy	supremacy	NOUN
bjp-23604	12	17	of	of	ADP
bjp-23604	12	18	750	750	NUM
bjp-23604	12	19	mg/12	mg/12	PROPN
bjp-23604	12	20	hours	hour	NOUN
bjp-23604	12	21	over	over	ADP
bjp-23604	12	22	500	500	NUM
bjp-23604	12	23	mg/12	mg/12	PROPN
bjp-23604	12	24	hours	hour	NOUN
bjp-23604	12	25	dosing	dose	VERB
bjp-23604	12	26	regimen	regiman	NOUN
bjp-23604	12	27	.	.	PUNCT
bjp-23604	13	1	even	even	ADV
bjp-23604	13	2	though	though	SCONJ
bjp-23604	13	3	all	all	DET
bjp-23604	13	4	strains	strain	NOUN
bjp-23604	13	5	were	be	AUX
bjp-23604	13	6	fully	fully	ADV
bjp-23604	13	7	susceptible	susceptible	ADJ
bjp-23604	13	8	to	to	ADP
bjp-23604	13	9	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	13	10	,	,	PUNCT
bjp-23604	13	11	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	13	12	/	/	SYM
bjp-23604	13	13	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	13	14	parameters	parameter	NOUN
bjp-23604	13	15	did	do	AUX
bjp-23604	13	16	not	not	PART
bjp-23604	13	17	meet	meet	VERB
bjp-23604	13	18	target	target	NOUN
bjp-23604	13	19	thresholds	threshold	NOUN
bjp-23604	13	20	for	for	ADP
bjp-23604	13	21	pathogens	pathogen	NOUN
bjp-23604	13	22	with	with	ADP
bjp-23604	13	23	mic	mic	ADJ
bjp-23604	13	24	over	over	ADP
bjp-23604	13	25	0.1	0.1	NUM
bjp-23604	13	26	-	-	SYM
bjp-23604	13	27	0.2	0.2	NUM
bjp-23604	13	28	µg	µg	NOUN
bjp-23604	13	29	/	/	SYM
bjp-23604	13	30	ml	ml	NOUN
bjp-23604	13	31	regardless	regardless	ADV
bjp-23604	13	32	of	of	ADP
bjp-23604	13	33	the	the	DET
bjp-23604	13	34	administered	administer	VERB
bjp-23604	13	35	dose	dose	NOUN
bjp-23604	13	36	.	.	PUNCT
bjp-23604	14	1	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	14	2	remains	remain	VERB
bjp-23604	14	3	an	an	DET
bjp-23604	14	4	excellent	excellent	ADJ
bjp-23604	14	5	choice	choice	NOUN
bjp-23604	14	6	for	for	ADP
bjp-23604	14	7	treatment	treatment	NOUN
bjp-23604	14	8	of	of	ADP
bjp-23604	14	9	complicated	complicated	ADJ
bjp-23604	14	10	urinary	urinary	ADJ
bjp-23604	14	11	tract	tract	NOUN
bjp-23604	14	12	infections	infection	NOUN
bjp-23604	14	13	caused	cause	VERB
bjp-23604	14	14	by	by	ADP
bjp-23604	14	15	gram	gram	NOUN
bjp-23604	14	16	-	-	PUNCT
bjp-23604	14	17	negative	negative	ADJ
bjp-23604	14	18	bacteria	bacteria	NOUN
bjp-23604	14	19	,	,	PUNCT
bjp-23604	14	20	but	but	CCONJ
bjp-23604	14	21	in	in	ADP
bjp-23604	14	22	infection	infection	NOUN
bjp-23604	14	23	caused	cause	VERB
bjp-23604	14	24	by	by	ADP
bjp-23604	14	25	gram	gram	NOUN
bjp-23604	14	26	-	-	PUNCT
bjp-23604	14	27	positive	positive	ADJ
bjp-23604	14	28	strains	strain	NOUN
bjp-23604	14	29	,	,	PUNCT
bjp-23604	14	30	deeper	deep	ADJ
bjp-23604	14	31	analysis	analysis	NOUN
bjp-23604	14	32	is	be	AUX
bjp-23604	14	33	necessary	necessary	ADJ
bjp-23604	14	34	in	in	ADP
bjp-23604	14	35	order	order	NOUN
bjp-23604	14	36	to	to	PART
bjp-23604	14	37	achieve	achieve	VERB
bjp-23604	14	38	optimal	optimal	ADJ
bjp-23604	14	39	results	result	NOUN
bjp-23604	14	40	.	.	PUNCT
bjp-23604	15	1	article	article	NOUN
bjp-23604	15	2	info	info	NOUN
bjp-23604	15	3	received	receive	VERB
bjp-23604	15	4	:	:	PUNCT
bjp-23604	15	5	10	10	NUM
bjp-23604	15	6	june	june	PROPN
bjp-23604	15	7	2015	2015	NUM
bjp-23604	15	8	accepted	accept	VERB
bjp-23604	15	9	:	:	PUNCT
bjp-23604	15	10	17	17	NUM
bjp-23604	15	11	june	june	PROPN
bjp-23604	15	12	2015	2015	NUM
bjp-23604	15	13	available	available	ADJ
bjp-23604	15	14	online	online	ADV
bjp-23604	15	15	:	:	PUNCT
bjp-23604	15	16	12	12	NUM
bjp-23604	15	17	july	july	PROPN
bjp-23604	15	18	2015	2015	NUM
bjp-23604	15	19	doi	doi	NOUN
bjp-23604	15	20	:	:	PUNCT
bjp-23604	15	21	10.3329	10.3329	NUM
bjp-23604	15	22	/	/	SYM
bjp-23604	15	23	bjp.v10i3.23604	bjp.v10i3.23604	PROPN
bjp-23604	15	24	cite	cite	VERB
bjp-23604	15	25	this	this	DET
bjp-23604	15	26	article	article	NOUN
bjp-23604	15	27	:	:	PUNCT
bjp-23604	15	28	tomas	tomas	PROPN
bjp-23604	15	29	a	a	PRON
bjp-23604	15	30	,	,	PUNCT
bjp-23604	15	31	tomić	tomić	NOUN
bjp-23604	15	32	n	n	CCONJ
bjp-23604	15	33	,	,	PUNCT
bjp-23604	15	34	popović	popović	ADJ
bjp-23604	15	35	r	r	NOUN
bjp-23604	15	36	,	,	PUNCT
bjp-23604	15	37	mikov	mikov	NOUN
bjp-23604	15	38	m	m	PROPN
bjp-23604	15	39	,	,	PUNCT
bjp-23604	15	40	horvat	horvat	NOUN
bjp-23604	15	41	o	o	NOUN
bjp-23604	15	42	,	,	PUNCT
bjp-23604	15	43	sabo	sabo	NOUN
bjp-23604	15	44	a	a	PRON
bjp-23604	15	45	,	,	PUNCT
bjp-23604	15	46	tomić	tomić	NOUN
bjp-23604	15	47	z.	z.	PROPN
bjp-23604	15	48	pharmacokinetic	pharmacokinetic	PROPN
bjp-23604	15	49	/	/	SYM
bjp-23604	15	50	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	15	51	based	base	VERB
bjp-23604	15	52	dosing	dosing	NOUN
bjp-23604	15	53	of	of	ADP
bjp-23604	15	54	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	15	55	in	in	ADP
bjp-23604	15	56	complicated	complicated	ADJ
bjp-23604	15	57	urinary	urinary	ADJ
bjp-23604	15	58	tract	tract	NOUN
bjp-23604	15	59	infections	infection	NOUN
bjp-23604	15	60	.	.	PUNCT
bjp-23604	16	1	bangladesh	bangladesh	PROPN
bjp-23604	16	2	j	j	PROPN
bjp-23604	16	3	pharmacol	pharmacol	PROPN
bjp-23604	16	4	.	.	PROPN
bjp-23604	17	1	2015	2015	NUM
bjp-23604	17	2	;	;	PUNCT
bjp-23604	17	3	10	10	NUM
bjp-23604	17	4	:	:	SYM
bjp-23604	17	5	621	621	NUM
bjp-23604	17	6	-26	-26	NUM
bjp-23604	17	7	.	.	PUNCT
bjp-23604	18	1	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	18	2	/	/	SYM
bjp-23604	18	3	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	18	4	based	base	VERB
bjp-23604	18	5	dosing	dosing	NOUN
bjp-23604	18	6	of	of	ADP
bjp-23604	18	7	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	18	8	in	in	ADP
bjp-23604	18	9	complicated	complicated	ADJ
bjp-23604	18	10	urinary	urinary	ADJ
bjp-23604	18	11	tract	tract	NOUN
bjp-23604	18	12	infections	infection	NOUN
bjp-23604	18	13	ana	ana	PROPN
bjp-23604	18	14	sabo1	sabo1	PROPN
bjp-23604	18	15	,	,	PUNCT
bjp-23604	18	16	ana	ana	PROPN
bjp-23604	18	17	tomas1	tomas1	PROPN
bjp-23604	18	18	,	,	PUNCT
bjp-23604	18	19	nataša	nataša	ADJ
bjp-23604	18	20	tomić2	tomić2	X
bjp-23604	18	21	,	,	PUNCT
bjp-23604	18	22	momir	momir	ADJ
bjp-23604	18	23	mikov1	mikov1	PROPN
bjp-23604	18	24	,	,	PUNCT
bjp-23604	18	25	olga	olga	PROPN
bjp-23604	18	26	horvat1	horvat1	PROPN
bjp-23604	18	27	,	,	PUNCT
bjp-23604	18	28	radmila	radmila	NOUN
bjp-23604	18	29	popović2	popović2	NOUN
bjp-23604	18	30	and	and	CCONJ
bjp-23604	18	31	zdenko	zdenko	PROPN
bjp-23604	18	32	tomić1	tomić1	X
bjp-23604	19	1	1department	1department	NUM
bjp-23604	19	2	of	of	ADP
bjp-23604	19	3	pharmacology	pharmacology	NOUN
bjp-23604	19	4	,	,	PUNCT
bjp-23604	19	5	toxicology	toxicology	NOUN
bjp-23604	19	6	and	and	CCONJ
bjp-23604	19	7	clinical	clinical	ADJ
bjp-23604	19	8	pharmacology	pharmacology	NOUN
bjp-23604	19	9	,	,	PUNCT
bjp-23604	19	10	faculty	faculty	NOUN
bjp-23604	19	11	of	of	ADP
bjp-23604	19	12	medicine	medicine	NOUN
bjp-23604	19	13	,	,	PUNCT
bjp-23604	19	14	university	university	NOUN
bjp-23604	19	15	of	of	ADP
bjp-23604	19	16	novi	novi	PROPN
bjp-23604	19	17	sad	sad	PROPN
bjp-23604	19	18	,	,	PUNCT
bjp-23604	19	19	serbia	serbia	PROPN
bjp-23604	19	20	;	;	PUNCT
bjp-23604	19	21	2institute	2institute	NUM
bjp-23604	19	22	of	of	ADP
bjp-23604	19	23	emergency	emergency	NOUN
bjp-23604	19	24	medicine	medicine	NOUN
bjp-23604	19	25	,	,	PUNCT
bjp-23604	19	26	clinical	clinical	ADJ
bjp-23604	19	27	centre	centre	NOUN
bjp-23604	19	28	of	of	ADP
bjp-23604	19	29	vojvodina	vojvodina	NOUN
bjp-23604	19	30	,	,	PUNCT
bjp-23604	19	31	novi	novi	PROPN
bjp-23604	19	32	sad	sad	PROPN
bjp-23604	19	33	,	,	PUNCT
bjp-23604	19	34	serbia	serbia	PROPN
bjp-23604	19	35	.	.	PUNCT
bjp-23604	20	1	tative	tative	PROPN
bjp-23604	20	2	relationship	relationship	NOUN
bjp-23604	20	3	between	between	ADP
bjp-23604	20	4	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	20	5	parameters	parameter	NOUN
bjp-23604	20	6	of	of	ADP
bjp-23604	20	7	antibacterial	antibacterial	ADJ
bjp-23604	20	8	drugs	drug	NOUN
bjp-23604	20	9	and	and	CCONJ
bjp-23604	20	10	a	a	DET
bjp-23604	20	11	microbiological	microbiological	ADJ
bjp-23604	20	12	parameter	parameter	NOUN
bjp-23604	20	13	constituted	constitute	VERB
bjp-23604	20	14	in	in	ADP
bjp-23604	20	15	a	a	DET
bjp-23604	20	16	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	20	17	/	/	SYM
bjp-23604	20	18	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	20	19	indices	index	NOUN
bjp-23604	20	20	which	which	PRON
bjp-23604	20	21	correlate	correlate	VERB
bjp-23604	20	22	with	with	ADP
bjp-23604	20	23	therapeutic	therapeutic	ADJ
bjp-23604	20	24	outcome	outcome	NOUN
bjp-23604	20	25	.	.	PUNCT
bjp-23604	21	1	for	for	ADP
bjp-23604	21	2	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	21	3	,	,	PUNCT
bjp-23604	21	4	parameters	parameter	NOUN
bjp-23604	21	5	that	that	PRON
bjp-23604	21	6	correlate	correlate	VERB
bjp-23604	21	7	best	well	ADV
bjp-23604	21	8	with	with	ADP
bjp-23604	21	9	the	the	DET
bjp-23604	21	10	clinical	clinical	ADJ
bjp-23604	21	11	efficacy	efficacy	NOUN
bjp-23604	21	12	are	be	AUX
bjp-23604	21	13	the	the	DET
bjp-23604	21	14	auc24	auc24	ADJ
bjp-23604	21	15	/	/	SYM
bjp-23604	21	16	mic	mic	NOUN
bjp-23604	22	1	[	[	X
bjp-23604	22	2	ratio	ratio	NOUN
bjp-23604	22	3	between	between	ADP
bjp-23604	22	4	24	24	NUM
bjp-23604	22	5	-	-	PUNCT
bjp-23604	22	6	hours	hour	NOUN
bjp-23604	22	7	area	area	NOUN
bjp-23604	22	8	under	under	ADP
bjp-23604	22	9	the	the	DET
bjp-23604	22	10	concentration	concentration	NOUN
bjp-23604	22	11	–	–	PUNCT
bjp-23604	22	12	time	time	NOUN
bjp-23604	22	13	curve	curve	NOUN
bjp-23604	22	14	and	and	CCONJ
bjp-23604	22	15	the	the	DET
bjp-23604	22	16	minimum	minimum	ADJ
bjp-23604	22	17	inhibitory	inhibitory	ADJ
bjp-23604	22	18	concentration	concentration	NOUN
bjp-23604	22	19	(	(	PUNCT
bjp-23604	22	20	mic	mic	ADJ
bjp-23604	22	21	)	)	PUNCT
bjp-23604	22	22	]	]	PUNCT
bjp-23604	22	23	and	and	CCONJ
bjp-23604	22	24	cmax	cmax	VERB
bjp-23604	22	25	/	/	SYM
bjp-23604	22	26	mic	mic	ADJ
bjp-23604	22	27	ratio	ratio	NOUN
bjp-23604	22	28	(	(	PUNCT
bjp-23604	22	29	jacobs	jacobs	PROPN
bjp-23604	22	30	,	,	PUNCT
bjp-23604	22	31	2001	2001	NUM
bjp-23604	22	32	;	;	PUNCT
bjp-23604	22	33	wispelwey	wispelwey	PROPN
bjp-23604	22	34	,	,	PUNCT
bjp-23604	22	35	2005	2005	NUM
bjp-23604	22	36	)	)	PUNCT
bjp-23604	22	37	.	.	PUNCT
bjp-23604	23	1	one	one	NUM
bjp-23604	23	2	of	of	ADP
bjp-23604	23	3	the	the	DET
bjp-23604	23	4	strong	strong	ADJ
bjp-23604	23	5	suits	suit	NOUN
bjp-23604	23	6	of	of	ADP
bjp-23604	23	7	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	23	8	,	,	PUNCT
bjp-23604	23	9	the	the	DET
bjp-23604	23	10	postantibiotic	postantibiotic	ADJ
bjp-23604	23	11	effect	effect	NOUN
bjp-23604	23	12	also	also	ADV
bjp-23604	23	13	has	have	VERB
bjp-23604	23	14	the	the	DET
bjp-23604	23	15	impact	impact	NOUN
bjp-23604	23	16	on	on	ADP
bjp-23604	23	17	dosing	dose	VERB
bjp-23604	23	18	strategies	strategy	NOUN
bjp-23604	23	19	.	.	PUNCT
bjp-23604	24	1	presence	presence	NOUN
bjp-23604	24	2	of	of	ADP
bjp-23604	24	3	postantibiotic	postantibiotic	ADJ
bjp-23604	24	4	effect	effect	NOUN
bjp-23604	24	5	,	,	PUNCT
bjp-23604	24	6	the	the	DET
bjp-23604	24	7	suppression	suppression	NOUN
bjp-23604	24	8	of	of	ADP
bjp-23604	24	9	bacterial	bacterial	ADJ
bjp-23604	24	10	growth	growth	NOUN
bjp-23604	24	11	following	follow	VERB
bjp-23604	24	12	limited	limited	ADJ
bjp-23604	24	13	exposure	exposure	NOUN
bjp-23604	24	14	of	of	ADP
bjp-23604	24	15	organisms	organism	NOUN
bjp-23604	24	16	to	to	ADP
bjp-23604	24	17	antimicrobial	antimicrobial	ADJ
bjp-23604	24	18	(	(	PUNCT
bjp-23604	24	19	craig	craig	PROPN
bjp-23604	24	20	,	,	PUNCT
bjp-23604	24	21	2001	2001	NUM
bjp-23604	24	22	)	)	PUNCT
bjp-23604	24	23	,	,	PUNCT
bjp-23604	24	24	may	may	AUX
bjp-23604	24	25	improve	improve	VERB
bjp-23604	24	26	the	the	DET
bjp-23604	24	27	therapeutic	therapeutic	ADJ
bjp-23604	24	28	outcome	outcome	NOUN
bjp-23604	24	29	in	in	ADP
bjp-23604	24	30	case	case	NOUN
bjp-23604	24	31	of	of	ADP
bjp-23604	24	32	margin	margin	NOUN
bjp-23604	24	33	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	24	34	/	/	SYM
bjp-23604	24	35	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	24	36	index	index	NOUN
bjp-23604	24	37	values	value	NOUN
bjp-23604	24	38	and	and	CCONJ
bjp-23604	24	39	may	may	AUX
bjp-23604	24	40	provide	provide	VERB
bjp-23604	24	41	administration	administration	NOUN
bjp-23604	24	42	at	at	ADP
bjp-23604	24	43	longer	long	ADV
bjp-23604	24	44	dosing	dose	VERB
bjp-23604	24	45	intervals	interval	NOUN
bjp-23604	24	46	.	.	PUNCT
bjp-23604	25	1	the	the	DET
bjp-23604	25	2	aim	aim	NOUN
bjp-23604	25	3	of	of	ADP
bjp-23604	25	4	this	this	DET
bjp-23604	25	5	study	study	NOUN
bjp-23604	25	6	was	be	AUX
bjp-23604	25	7	to	to	PART
bjp-23604	25	8	determine	determine	VERB
bjp-23604	25	9	the	the	DET
bjp-23604	25	10	effect	effect	NOUN
bjp-23604	25	11	of	of	ADP
bjp-23604	25	12	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	25	13	on	on	ADP
bjp-23604	25	14	urinary	urinary	ADJ
bjp-23604	25	15	bacterial	bacterial	ADJ
bjp-23604	25	16	isolates	isolate	NOUN
bjp-23604	25	17	,	,	PUNCT
bjp-23604	25	18	determine	determine	VERB
bjp-23604	25	19	the	the	DET
bjp-23604	25	20	postantibiotic	postantibiotic	ADJ
bjp-23604	25	21	effect	effect	NOUN
bjp-23604	25	22	and	and	CCONJ
bjp-23604	25	23	incorporate	incorporate	VERB
bjp-23604	25	24	this	this	DET
bjp-23604	25	25	information	information	NOUN
bjp-23604	25	26	with	with	ADP
bjp-23604	25	27	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	25	28	profile	profile	NOUN
bjp-23604	25	29	of	of	ADP
bjp-23604	25	30	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	25	31	in	in	ADP
bjp-23604	25	32	order	order	NOUN
bjp-23604	25	33	to	to	PART
bjp-23604	25	34	evaluate	evaluate	VERB
bjp-23604	25	35	current	current	ADJ
bjp-23604	25	36	standard	standard	ADJ
bjp-23604	25	37	dosing	dose	VERB
bjp-23604	25	38	regimen	regiman	NOUN
bjp-23604	25	39	of	of	ADP
bjp-23604	25	40	500	500	NUM
bjp-23604	25	41	mg/12	mg/12	PROPN
bjp-23604	25	42	hours	hour	NOUN
bjp-23604	25	43	and	and	CCONJ
bjp-23604	25	44	750	750	NUM
bjp-23604	25	45	mg/12	mg/12	PROPN
bjp-23604	25	46	hours	hour	NOUN
bjp-23604	25	47	for	for	ADP
bjp-23604	25	48	orally	orally	ADV
bjp-23604	25	49	administered	administer	VERB
bjp-23604	25	50	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	25	51	in	in	ADP
bjp-23604	25	52	complicated	complicated	ADJ
bjp-23604	25	53	urinary	urinary	ADJ
bjp-23604	25	54	tract	tract	NOUN
bjp-23604	25	55	infections	infection	NOUN
bjp-23604	25	56	.	.	PUNCT
bjp-23604	26	1	materials	material	NOUN
bjp-23604	26	2	and	and	CCONJ
bjp-23604	26	3	methods	method	NOUN
bjp-23604	26	4	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	26	5	simulation	simulation	NOUN
bjp-23604	26	6	in	in	ADP
bjp-23604	26	7	order	order	NOUN
bjp-23604	26	8	to	to	PART
bjp-23604	26	9	obtain	obtain	VERB
bjp-23604	26	10	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	26	11	parameters	parameter	NOUN
bjp-23604	26	12	(	(	PUNCT
bjp-23604	26	13	auc	auc	NOUN
bjp-23604	26	14	,	,	PUNCT
bjp-23604	26	15	cmax	cmax	NOUN
bjp-23604	26	16	)	)	PUNCT
bjp-23604	26	17	necessary	necessary	ADJ
bjp-23604	26	18	for	for	ADP
bjp-23604	26	19	calculation	calculation	NOUN
bjp-23604	26	20	of	of	ADP
bjp-23604	26	21	efficacy	efficacy	NOUN
bjp-23604	26	22	indices	index	NOUN
bjp-23604	26	23	,	,	PUNCT
bjp-23604	26	24	simulation	simulation	NOUN
bjp-23604	26	25	was	be	AUX
bjp-23604	26	26	performed	perform	VERB
bjp-23604	26	27	using	use	VERB
bjp-23604	26	28	literary	literary	ADJ
bjp-23604	26	29	values	value	NOUN
bjp-23604	26	30	of	of	ADP
bjp-23604	26	31	the	the	DET
bjp-23604	26	32	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	26	33	parameters	parameter	NOUN
bjp-23604	26	34	for	for	ADP
bjp-23604	26	35	one	one	NUM
bjp-23604	26	36	-	-	PUNCT
bjp-23604	26	37	compartment	compartment	NOUN
bjp-23604	26	38	model	model	NOUN
bjp-23604	26	39	(	(	PUNCT
bjp-23604	26	40	f	f	X
bjp-23604	26	41	,	,	PUNCT
bjp-23604	26	42	vd	vd	NOUN
bjp-23604	26	43	,	,	PUNCT
bjp-23604	26	44	ka	ka	PROPN
bjp-23604	26	45	,	,	PUNCT
bjp-23604	26	46	ke	ke	PROPN
bjp-23604	26	47	)	)	PUNCT
bjp-23604	26	48	using	use	VERB
bjp-23604	26	49	a	a	DET
bjp-23604	26	50	methodology	methodology	NOUN
bjp-23604	26	51	described	describe	VERB
bjp-23604	26	52	previously	previously	ADV
bjp-23604	26	53	(	(	PUNCT
bjp-23604	26	54	navarro	navarro	PROPN
bjp-23604	26	55	et	et	PROPN
bjp-23604	26	56	al	al	PROPN
bjp-23604	26	57	.	.	PROPN
bjp-23604	26	58	,	,	PUNCT
bjp-23604	26	59	2002a	2002a	NUM
bjp-23604	26	60	;	;	PUNCT
bjp-23604	26	61	navarro	navarro	PROPN
bjp-23604	26	62	et	et	PROPN
bjp-23604	26	63	al	al	PROPN
bjp-23604	26	64	.	.	PROPN
bjp-23604	26	65	,	,	PUNCT
bjp-23604	26	66	2002b	2002b	NUM
bjp-23604	26	67	)	)	PUNCT
bjp-23604	26	68	.	.	PUNCT
bjp-23604	27	1	time	time	NOUN
bjp-23604	27	2	-	-	PUNCT
bjp-23604	27	3	concentration	concentration	NOUN
bjp-23604	27	4	curves	curve	NOUN
bjp-23604	27	5	were	be	AUX
bjp-23604	27	6	simulated	simulate	VERB
bjp-23604	27	7	for	for	ADP
bjp-23604	27	8	500	500	NUM
bjp-23604	27	9	mg	mg	NOUN
bjp-23604	27	10	and	and	CCONJ
bjp-23604	27	11	750	750	NUM
bjp-23604	27	12	mg	mg	NOUN
bjp-23604	27	13	twice	twice	ADV
bjp-23604	27	14	daily	daily	ADV
bjp-23604	27	15	orally	orally	ADV
bjp-23604	27	16	administered	administer	VERB
bjp-23604	27	17	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	27	18	.	.	PUNCT
bjp-23604	28	1	simulation	simulation	NOUN
bjp-23604	28	2	was	be	AUX
bjp-23604	28	3	carried	carry	VERB
bjp-23604	28	4	out	out	ADP
bjp-23604	28	5	using	use	VERB
bjp-23604	28	6	winnonlin	winnonlin	PROPN
bjp-23604	28	7	®	®	NOUN
bjp-23604	28	8	version	version	NOUN
bjp-23604	28	9	4.1	4.1	NUM
bjp-23604	28	10	by	by	ADP
bjp-23604	28	11	pharsight	pharsight	NOUN
bjp-23604	28	12	corporation	corporation	NOUN
bjp-23604	28	13	.	.	PUNCT
bjp-23604	29	1	first	first	ADJ
bjp-23604	29	2	-	-	PUNCT
bjp-23604	29	3	order	order	NOUN
bjp-23604	29	4	input	input	NOUN
bjp-23604	29	5	,	,	PUNCT
bjp-23604	29	6	first	first	ADJ
bjp-23604	29	7	-	-	PUNCT
bjp-23604	29	8	order	order	NOUN
bjp-23604	29	9	output	output	NOUN
bjp-23604	29	10	,	,	PUNCT
bjp-23604	29	11	and	and	CCONJ
bjp-23604	29	12	no	no	DET
bjp-23604	29	13	lag	lag	NOUN
bjp-23604	29	14	time	time	NOUN
bjp-23604	29	15	model	model	NOUN
bjp-23604	29	16	from	from	ADP
bjp-23604	29	17	winnonlin	winnonlin	PROPN
bjp-23604	29	18	model	model	NOUN
bjp-23604	29	19	library	library	NOUN
bjp-23604	29	20	was	be	AUX
bjp-23604	29	21	used	use	VERB
bjp-23604	29	22	.	.	PUNCT
bjp-23604	30	1	input	input	NOUN
bjp-23604	30	2	for	for	ADP
bjp-23604	30	3	volume	volume	NOUN
bjp-23604	30	4	of	of	ADP
bjp-23604	30	5	distribution	distribution	NOUN
bjp-23604	30	6	(	(	PUNCT
bjp-23604	30	7	vd	vd	NOUN
bjp-23604	30	8	)	)	PUNCT
bjp-23604	30	9	was	be	AUX
bjp-23604	30	10	expressed	express	VERB
bjp-23604	30	11	in	in	ADP
bjp-23604	30	12	liters	liter	NOUN
bjp-23604	30	13	using	use	VERB
bjp-23604	30	14	standard	standard	ADJ
bjp-23604	30	15	weight	weight	NOUN
bjp-23604	30	16	of	of	ADP
bjp-23604	30	17	70	70	NUM
bjp-23604	30	18	kg	kg	NOUN
bjp-23604	30	19	.	.	PUNCT
bjp-23604	31	1	dosing	dose	VERB
bjp-23604	31	2	parameters	parameter	NOUN
bjp-23604	31	3	including	include	VERB
bjp-23604	31	4	the	the	DET
bjp-23604	31	5	number	number	NOUN
bjp-23604	31	6	of	of	ADP
bjp-23604	31	7	doses	dose	NOUN
bjp-23604	31	8	(	(	PUNCT
bjp-23604	31	9	3	3	NUM
bjp-23604	31	10	)	)	PUNCT
bjp-23604	31	11	,	,	PUNCT
bjp-23604	31	12	amount	amount	NOUN
bjp-23604	31	13	of	of	ADP
bjp-23604	31	14	the	the	DET
bjp-23604	31	15	dose	dose	NOUN
bjp-23604	31	16	(	(	PUNCT
bjp-23604	31	17	500	500	NUM
bjp-23604	31	18	mg	mg	NUM
bjp-23604	31	19	and	and	CCONJ
bjp-23604	31	20	750	750	NUM
bjp-23604	31	21	mg	mg	NUM
bjp-23604	31	22	)	)	PUNCT
bjp-23604	31	23	,	,	PUNCT
bjp-23604	31	24	and	and	CCONJ
bjp-23604	31	25	dosing	dosing	NOUN
bjp-23604	31	26	time	time	NOUN
bjp-23604	31	27	(	(	PUNCT
bjp-23604	31	28	0	0	NUM
bjp-23604	31	29	hour	hour	NOUN
bjp-23604	31	30	and	and	CCONJ
bjp-23604	31	31	12	12	NUM
bjp-23604	31	32	hours	hour	NOUN
bjp-23604	31	33	)	)	PUNCT
bjp-23604	31	34	were	be	AUX
bjp-23604	31	35	entered	enter	VERB
bjp-23604	31	36	and	and	CCONJ
bjp-23604	31	37	simulation	simulation	NOUN
bjp-23604	31	38	was	be	AUX
bjp-23604	31	39	performed	perform	VERB
bjp-23604	31	40	.	.	PUNCT
bjp-23604	32	1	bioavailability	bioavailability	NOUN
bjp-23604	32	2	(	(	PUNCT
bjp-23604	32	3	f	f	X
bjp-23604	32	4	)	)	PUNCT
bjp-23604	32	5	was	be	AUX
bjp-23604	32	6	included	include	VERB
bjp-23604	32	7	into	into	ADP
bjp-23604	32	8	dose	dose	NOUN
bjp-23604	32	9	calculation	calculation	NOUN
bjp-23604	32	10	.	.	PUNCT
bjp-23604	33	1	for	for	SCONJ
bjp-23604	33	2	model	model	NOUN
bjp-23604	33	3	used	use	VERB
bjp-23604	33	4	,	,	PUNCT
bjp-23604	33	5	ka	ka	PROPN
bjp-23604	33	6	,	,	PUNCT
bjp-23604	33	7	the	the	DET
bjp-23604	33	8	absorption	absorption	NOUN
bjp-23604	33	9	rate	rate	NOUN
bjp-23604	33	10	constant	constant	ADJ
bjp-23604	33	11	,	,	PUNCT
bjp-23604	33	12	is	be	AUX
bjp-23604	33	13	the	the	DET
bjp-23604	33	14	rate	rate	NOUN
bjp-23604	33	15	at	at	ADP
bjp-23604	33	16	which	which	PRON
bjp-23604	33	17	drug	drug	NOUN
bjp-23604	33	18	enters	enter	VERB
bjp-23604	33	19	the	the	DET
bjp-23604	33	20	central	central	ADJ
bjp-23604	33	21	compartment	compartment	NOUN
bjp-23604	33	22	from	from	ADP
bjp-23604	33	23	outside	outside	ADP
bjp-23604	33	24	the	the	DET
bjp-23604	33	25	system	system	NOUN
bjp-23604	33	26	,	,	PUNCT
bjp-23604	33	27	and	and	CCONJ
bjp-23604	33	28	ke	ke	NOUN
bjp-23604	33	29	,	,	PUNCT
bjp-23604	33	30	the	the	DET
bjp-23604	33	31	elimination	elimination	NOUN
bjp-23604	33	32	rate	rate	NOUN
bjp-23604	33	33	constant	constant	ADJ
bjp-23604	33	34	,	,	PUNCT
bjp-23604	33	35	is	be	AUX
bjp-23604	33	36	the	the	DET
bjp-23604	33	37	rate	rate	NOUN
bjp-23604	33	38	at	at	ADP
bjp-23604	33	39	which	which	PRON
bjp-23604	33	40	drug	drug	NOUN
bjp-23604	33	41	leaves	leave	VERB
bjp-23604	33	42	the	the	DET
bjp-23604	33	43	system	system	NOUN
bjp-23604	33	44	from	from	ADP
bjp-23604	33	45	the	the	DET
bjp-23604	33	46	central	central	ADJ
bjp-23604	33	47	compartment	compartment	NOUN
bjp-23604	33	48	.	.	PUNCT
bjp-23604	34	1	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	34	2	parameters	parameter	NOUN
bjp-23604	34	3	used	use	VERB
bjp-23604	34	4	for	for	ADP
bjp-23604	34	5	simulations	simulation	NOUN
bjp-23604	34	6	were	be	AUX
bjp-23604	34	7	:	:	PUNCT
bjp-23604	34	8	f	f	X
bjp-23604	34	9	=	=	SYM
bjp-23604	34	10	0.7	0.7	NUM
bjp-23604	34	11	,	,	PUNCT
bjp-23604	34	12	ka	ka	PROPN
bjp-23604	35	1	=	=	PROPN
bjp-23604	35	2	2.5	2.5	NUM
bjp-23604	35	3	h-1	h-1	NOUN
bjp-23604	35	4	,	,	PUNCT
bjp-23604	35	5	vd	vd	NOUN
bjp-23604	35	6	=	=	SYM
bjp-23604	35	7	3.7	3.7	NUM
bjp-23604	35	8	l	l	NOUN
bjp-23604	35	9	/	/	SYM
bjp-23604	35	10	kg	kg	PROPN
bjp-23604	35	11	and	and	CCONJ
bjp-23604	35	12	ke=0.19	ke=0.19	PROPN
bjp-23604	35	13	h-1	h-1	PROPN
bjp-23604	35	14	(	(	PUNCT
bjp-23604	35	15	navarro	navarro	PROPN
bjp-23604	35	16	et	et	PROPN
bjp-23604	35	17	al	al	PROPN
bjp-23604	35	18	.	.	PROPN
bjp-23604	35	19	,	,	PUNCT
bjp-23604	35	20	2002b	2002b	NUM
bjp-23604	35	21	)	)	PUNCT
bjp-23604	35	22	.	.	PUNCT
bjp-23604	36	1	bacterial	bacterial	ADJ
bjp-23604	36	2	strains	strain	NOUN
bjp-23604	36	3	and	and	CCONJ
bjp-23604	36	4	media	medium	NOUN
bjp-23604	36	5	two	two	NUM
bjp-23604	36	6	gram	gram	NOUN
bjp-23604	36	7	negative	negative	ADJ
bjp-23604	36	8	(	(	PUNCT
bjp-23604	36	9	escherichia	escherichia	NOUN
bjp-23604	36	10	coli	coli	NOUN
bjp-23604	36	11	,	,	PUNCT
bjp-23604	36	12	proteus	proteus	NOUN
bjp-23604	36	13	mirabilis	mirabilis	PROPN
bjp-23604	36	14	)	)	PUNCT
bjp-23604	36	15	and	and	CCONJ
bjp-23604	36	16	two	two	NUM
bjp-23604	36	17	gram	gram	NOUN
bjp-23604	36	18	positive	positive	ADJ
bjp-23604	36	19	strains	strain	NOUN
bjp-23604	36	20	(	(	PUNCT
bjp-23604	36	21	staphylococcus	staphylococcus	NOUN
bjp-23604	36	22	aureus	aureus	NOUN
bjp-23604	36	23	,	,	PUNCT
bjp-23604	36	24	s.	s.	PROPN
bjp-23604	36	25	epidermidis	epidermidis	PROPN
bjp-23604	36	26	)	)	PUNCT
bjp-23604	36	27	from	from	ADP
bjp-23604	36	28	clinical	clinical	ADJ
bjp-23604	36	29	urinary	urinary	ADJ
bjp-23604	36	30	isolates	isolate	NOUN
bjp-23604	36	31	were	be	AUX
bjp-23604	36	32	supplied	supply	VERB
bjp-23604	36	33	by	by	ADP
bjp-23604	36	34	institute	institute	PROPN
bjp-23604	36	35	of	of	ADP
bjp-23604	36	36	public	public	ADJ
bjp-23604	36	37	health	health	NOUN
bjp-23604	36	38	of	of	ADP
bjp-23604	36	39	vojvodina	vojvodina	NOUN
bjp-23604	36	40	,	,	PUNCT
bjp-23604	36	41	center	center	NOUN
bjp-23604	36	42	of	of	ADP
bjp-23604	36	43	microbiology	microbiology	NOUN
bjp-23604	36	44	.	.	PUNCT
bjp-23604	37	1	the	the	DET
bjp-23604	37	2	strains	strain	NOUN
bjp-23604	37	3	were	be	AUX
bjp-23604	37	4	cultured	cultured	ADJ
bjp-23604	37	5	in	in	ADP
bjp-23604	37	6	mueller	mueller	PROPN
bjp-23604	37	7	–	–	PUNCT
bjp-23604	37	8	hinton	hinton	PROPN
bjp-23604	37	9	broth	broth	NOUN
bjp-23604	37	10	(	(	PUNCT
bjp-23604	37	11	torlak	torlak	PROPN
bjp-23604	37	12	institute	institute	PROPN
bjp-23604	37	13	,	,	PUNCT
bjp-23604	37	14	belgrade	belgrade	PROPN
bjp-23604	37	15	,	,	PUNCT
bjp-23604	37	16	serbia	serbia	PROPN
bjp-23604	37	17	)	)	PUNCT
bjp-23604	37	18	and	and	CCONJ
bjp-23604	37	19	mueller	mueller	PROPN
bjp-23604	37	20	–	–	PUNCT
bjp-23604	37	21	hinton	hinton	PROPN
bjp-23604	37	22	agar	agar	NOUN
bjp-23604	37	23	(	(	PUNCT
bjp-23604	37	24	torlak	torlak	PROPN
bjp-23604	37	25	institute	institute	PROPN
bjp-23604	37	26	,	,	PUNCT
bjp-23604	37	27	belgrade	belgrade	PROPN
bjp-23604	37	28	,	,	PUNCT
bjp-23604	37	29	serbia	serbia	PROPN
bjp-23604	37	30	)	)	PUNCT
bjp-23604	37	31	was	be	AUX
bjp-23604	37	32	used	use	VERB
bjp-23604	37	33	for	for	ADP
bjp-23604	37	34	determination	determination	NOUN
bjp-23604	37	35	of	of	ADP
bjp-23604	37	36	viable	viable	ADJ
bjp-23604	37	37	counts	count	NOUN
bjp-23604	37	38	.	.	PUNCT
bjp-23604	38	1	inoculums	inoculum	NOUN
bjp-23604	38	2	were	be	AUX
bjp-23604	38	3	replenished	replenish	VERB
bjp-23604	38	4	day	day	NOUN
bjp-23604	38	5	before	before	SCONJ
bjp-23604	38	6	the	the	DET
bjp-23604	38	7	experiments	experiment	NOUN
bjp-23604	38	8	to	to	PART
bjp-23604	38	9	ensure	ensure	VERB
bjp-23604	38	10	the	the	DET
bjp-23604	38	11	logarithmic	logarithmic	ADJ
bjp-23604	38	12	phase	phase	NOUN
bjp-23604	38	13	of	of	ADP
bjp-23604	38	14	growth	growth	NOUN
bjp-23604	38	15	at	at	ADP
bjp-23604	38	16	the	the	DET
bjp-23604	38	17	time	time	NOUN
bjp-23604	38	18	of	of	ADP
bjp-23604	38	19	the	the	DET
bjp-23604	38	20	exposure	exposure	NOUN
bjp-23604	38	21	to	to	ADP
bjp-23604	38	22	antibiotic	antibiotic	ADJ
bjp-23604	38	23	.	.	PUNCT
bjp-23604	39	1	inoculum	inoculum	NOUN
bjp-23604	39	2	was	be	AUX
bjp-23604	39	3	prepared	prepare	VERB
bjp-23604	39	4	making	make	VERB
bjp-23604	39	5	a	a	DET
bjp-23604	39	6	direct	direct	ADJ
bjp-23604	39	7	saline	saline	NOUN
bjp-23604	39	8	suspension	suspension	NOUN
bjp-23604	39	9	colonies	colony	NOUN
bjp-23604	39	10	from	from	ADP
bjp-23604	39	11	a	a	DET
bjp-23604	39	12	pure	pure	ADJ
bjp-23604	39	13	culture	culture	NOUN
bjp-23604	39	14	,	,	PUNCT
bjp-23604	39	15	and	and	CCONJ
bjp-23604	39	16	it	it	PRON
bjp-23604	39	17	was	be	AUX
bjp-23604	39	18	adjusted	adjust	VERB
bjp-23604	39	19	using	use	VERB
bjp-23604	39	20	a	a	DET
bjp-23604	39	21	densitometer	densitometer	NOUN
bjp-23604	39	22	to	to	PART
bjp-23604	39	23	achieve	achieve	VERB
bjp-23604	39	24	a	a	DET
bjp-23604	39	25	0.5	0.5	NUM
bjp-23604	39	26	mcfarland	mcfarland	NOUN
bjp-23604	39	27	turbidity	turbidity	NOUN
bjp-23604	39	28	standard	standard	NOUN
bjp-23604	39	29	(	(	PUNCT
bjp-23604	39	30	this	this	PRON
bjp-23604	39	31	leads	lead	VERB
bjp-23604	39	32	to	to	ADP
bjp-23604	39	33	a	a	DET
bjp-23604	39	34	suspension	suspension	NOUN
bjp-23604	39	35	containing	contain	VERB
bjp-23604	39	36	approximately	approximately	ADV
bjp-23604	39	37	1	1	NUM
bjp-23604	39	38	x	x	SYM
bjp-23604	39	39	108	108	NUM
bjp-23604	39	40	cfu	cfu	NOUN
bjp-23604	39	41	/	/	SYM
bjp-23604	39	42	ml	ml	NOUN
bjp-23604	39	43	)	)	PUNCT
bjp-23604	39	44	.	.	PUNCT
bjp-23604	40	1	antimicrobial	antimicrobial	ADJ
bjp-23604	40	2	agents	agent	NOUN
bjp-23604	40	3	and	and	CCONJ
bjp-23604	40	4	mic	mic	ADJ
bjp-23604	40	5	determination	determination	NOUN
bjp-23604	40	6	the	the	DET
bjp-23604	40	7	antimicrobial	antimicrobial	ADJ
bjp-23604	40	8	agent	agent	NOUN
bjp-23604	40	9	used	use	VERB
bjp-23604	40	10	was	be	AUX
bjp-23604	40	11	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	40	12	(	(	PUNCT
bjp-23604	40	13	zdravlje	zdravlje	PROPN
bjp-23604	40	14	leskovac	leskovac	PROPN
bjp-23604	40	15	,	,	PUNCT
bjp-23604	40	16	serbia	serbia	PROPN
bjp-23604	40	17	)	)	PUNCT
bjp-23604	40	18	and	and	CCONJ
bjp-23604	40	19	stock	stock	NOUN
bjp-23604	40	20	solution	solution	NOUN
bjp-23604	40	21	from	from	ADP
bjp-23604	40	22	dry	dry	ADJ
bjp-23604	40	23	powder	powder	NOUN
bjp-23604	40	24	was	be	AUX
bjp-23604	40	25	prepared	prepare	VERB
bjp-23604	40	26	according	accord	VERB
bjp-23604	40	27	to	to	ADP
bjp-23604	40	28	manufacturer	manufacturer	NOUN
bjp-23604	40	29	’s	’s	PART
bjp-23604	40	30	recommendations	recommendation	NOUN
bjp-23604	40	31	.	.	PUNCT
bjp-23604	41	1	the	the	DET
bjp-23604	41	2	mic	mic	NOUN
bjp-23604	41	3	was	be	AUX
bjp-23604	41	4	determined	determine	VERB
bjp-23604	41	5	for	for	ADP
bjp-23604	41	6	each	each	DET
bjp-23604	41	7	isolate	isolate	NOUN
bjp-23604	41	8	using	use	VERB
bjp-23604	41	9	the	the	DET
bjp-23604	41	10	broth	broth	ADJ
bjp-23604	41	11	dilution	dilution	NOUN
bjp-23604	41	12	method	method	NOUN
bjp-23604	41	13	defined	define	VERB
bjp-23604	41	14	by	by	ADP
bjp-23604	41	15	clinical	clinical	ADJ
bjp-23604	41	16	and	and	CCONJ
bjp-23604	41	17	laboratory	laboratory	NOUN
bjp-23604	41	18	standards	standard	NOUN
bjp-23604	41	19	institute	institute	NOUN
bjp-23604	41	20	standards	standard	NOUN
bjp-23604	41	21	(	(	PUNCT
bjp-23604	41	22	clsi	clsi	NOUN
bjp-23604	41	23	,	,	PUNCT
bjp-23604	41	24	2006	2006	NUM
bjp-23604	41	25	)	)	PUNCT
bjp-23604	41	26	.	.	PUNCT
bjp-23604	42	1	serial	serial	VERB
bjp-23604	42	2	two	two	NUM
bjp-23604	42	3	-	-	PUNCT
bjp-23604	42	4	fold	fold	ADJ
bjp-23604	42	5	dilutions	dilution	NOUN
bjp-23604	42	6	of	of	ADP
bjp-23604	42	7	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	42	8	ranging	range	VERB
bjp-23604	42	9	from	from	ADP
bjp-23604	42	10	8	8	NUM
bjp-23604	42	11	to	to	ADP
bjp-23604	42	12	0.0039	0.0039	NUM
bjp-23604	42	13	µg	µg	NOUN
bjp-23604	42	14	/	/	SYM
bjp-23604	42	15	ml	ml	NOUN
bjp-23604	42	16	were	be	AUX
bjp-23604	42	17	prepared	prepare	VERB
bjp-23604	42	18	in	in	ADP
bjp-23604	42	19	m	m	PROPN
bjp-23604	42	20	u	u	NOUN
bjp-23604	42	21	e	e	NOUN
bjp-23604	42	22	l	l	NOUN
bjp-23604	42	23	l	l	NOUN
bjp-23604	42	24	e	e	NOUN
bjp-23604	42	25	r	r	NOUN
bjp-23604	42	26	h	h	NOUN
bjp-23604	42	27	in	in	ADP
bjp-23604	42	28	t	t	PROPN
bjp-23604	42	29	o	o	NOUN
bjp-23604	43	1	n	n	PRON
bjp-23604	43	2	b	b	NOUN
bjp-23604	43	3	r	r	NOUN
bjp-23604	43	4	o	o	NOUN
bjp-23604	43	5	t	t	NOUN
bjp-23604	43	6	h	h	NOUN
bjp-23604	43	7	.	.	PUNCT
bjp-23604	44	1	d	d	X
bjp-23604	44	2	u	u	NOUN
bjp-23604	44	3	r	r	VERB
bjp-23604	44	4	i	i	PRON
bjp-23604	44	5	n	n	CCONJ
bjp-23604	44	6	g	g	PROPN
bjp-23604	44	7	t	t	X
bjp-23604	44	8	e	e	PROPN
bjp-23604	44	9	s	s	PROPN
bjp-23604	44	10	t	t	NOUN
bjp-23604	44	11	in	in	ADP
bjp-23604	44	12	g	g	PROPN
bjp-23604	44	13	,	,	PUNCT
bjp-23604	44	14	multiple	multiple	ADJ
bjp-23604	44	15	standard	standard	ADJ
bjp-23604	44	16	test	test	NOUN
bjp-23604	44	17	tubes	tube	NOUN
bjp-23604	44	18	were	be	AUX
bjp-23604	44	19	filled	fill	VERB
bjp-23604	44	20	with	with	ADP
bjp-23604	44	21	broth	broth	NOUN
bjp-23604	44	22	containing	contain	VERB
bjp-23604	44	23	varying	vary	VERB
bjp-23604	44	24	concentrations	concentration	NOUN
bjp-23604	44	25	of	of	ADP
bjp-23604	44	26	the	the	DET
bjp-23604	44	27	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	44	28	and	and	CCONJ
bjp-23604	44	29	the	the	DET
bjp-23604	44	30	culture	culture	NOUN
bjp-23604	44	31	suspension	suspension	NOUN
bjp-23604	44	32	was	be	AUX
bjp-23604	44	33	then	then	ADV
bjp-23604	44	34	added	add	VERB
bjp-23604	44	35	to	to	ADP
bjp-23604	44	36	the	the	DET
bjp-23604	44	37	tubes	tube	NOUN
bjp-23604	44	38	.	.	PUNCT
bjp-23604	45	1	the	the	DET
bjp-23604	45	2	tubes	tube	NOUN
bjp-23604	45	3	were	be	AUX
bjp-23604	45	4	incubated	incubate	VERB
bjp-23604	45	5	at	at	ADP
bjp-23604	45	6	37	37	NUM
bjp-23604	45	7	°	°	ADP
bjp-23604	45	8	c	c	NOUN
bjp-23604	45	9	for	for	ADP
bjp-23604	45	10	24	24	NUM
bjp-23604	45	11	hours	hour	NOUN
bjp-23604	45	12	.	.	PUNCT
bjp-23604	46	1	following	follow	VERB
bjp-23604	46	2	the	the	DET
bjp-23604	46	3	incubation	incubation	NOUN
bjp-23604	46	4	,	,	PUNCT
bjp-23604	46	5	the	the	DET
bjp-23604	46	6	tubes	tube	NOUN
bjp-23604	46	7	were	be	AUX
bjp-23604	46	8	checked	check	VERB
bjp-23604	46	9	for	for	ADP
bjp-23604	46	10	bacterial	bacterial	ADJ
bjp-23604	46	11	growth	growth	NOUN
bjp-23604	46	12	.	.	PUNCT
bjp-23604	47	1	if	if	SCONJ
bjp-23604	47	2	the	the	DET
bjp-23604	47	3	broth	broth	NOUN
bjp-23604	47	4	became	become	VERB
bjp-23604	47	5	cloudy	cloudy	ADJ
bjp-23604	47	6	or	or	CCONJ
bjp-23604	47	7	a	a	DET
bjp-23604	47	8	layer	layer	NOUN
bjp-23604	47	9	of	of	ADP
bjp-23604	47	10	cells	cell	NOUN
bjp-23604	47	11	has	have	AUX
bjp-23604	47	12	made	make	VERB
bjp-23604	47	13	at	at	ADP
bjp-23604	47	14	the	the	DET
bjp-23604	47	15	bottom	bottom	NOUN
bjp-23604	47	16	,	,	PUNCT
bjp-23604	47	17	then	then	ADV
bjp-23604	47	18	bacterial	bacterial	ADJ
bjp-23604	47	19	growth	growth	NOUN
bjp-23604	47	20	has	have	AUX
bjp-23604	47	21	ensued	ensue	VERB
bjp-23604	47	22	.	.	PUNCT
bjp-23604	48	1	the	the	DET
bjp-23604	48	2	results	result	NOUN
bjp-23604	48	3	of	of	ADP
bjp-23604	48	4	the	the	DET
bjp-23604	48	5	broth	broth	ADJ
bjp-23604	48	6	dilution	dilution	NOUN
bjp-23604	48	7	method	method	NOUN
bjp-23604	48	8	are	be	AUX
bjp-23604	48	9	reported	report	VERB
bjp-23604	48	10	in	in	ADP
bjp-23604	48	11	mic	mic	ADJ
bjp-23604	48	12	,	,	PUNCT
bjp-23604	48	13	or	or	CCONJ
bjp-23604	48	14	the	the	DET
bjp-23604	48	15	lowest	low	ADJ
bjp-23604	48	16	concentration	concentration	NOUN
bjp-23604	48	17	of	of	ADP
bjp-23604	48	18	antibiotics	antibiotic	NOUN
bjp-23604	48	19	that	that	PRON
bjp-23604	48	20	stopped	stop	VERB
bjp-23604	48	21	bacterial	bacterial	ADJ
bjp-23604	48	22	growth	growth	NOUN
bjp-23604	48	23	.	.	PUNCT
bjp-23604	49	1	for	for	ADP
bjp-23604	49	2	every	every	DET
bjp-23604	49	3	strain	strain	NOUN
bjp-23604	49	4	,	,	PUNCT
bjp-23604	49	5	testing	testing	NOUN
bjp-23604	49	6	was	be	AUX
bjp-23604	49	7	performed	perform	VERB
bjp-23604	49	8	in	in	ADP
bjp-23604	49	9	triplicates	triplicate	NOUN
bjp-23604	49	10	,	,	PUNCT
bjp-23604	49	11	and	and	CCONJ
bjp-23604	49	12	results	result	NOUN
bjp-23604	49	13	were	be	AUX
bjp-23604	49	14	displayed	display	VERB
bjp-23604	49	15	as	as	ADP
bjp-23604	49	16	a	a	DET
bjp-23604	49	17	mean	mean	ADJ
bjp-23604	49	18	value	value	NOUN
bjp-23604	49	19	.	.	PUNCT
bjp-23604	50	1	postantibiotic	postantibiotic	ADJ
bjp-23604	50	2	effect	effect	NOUN
bjp-23604	50	3	determination	determination	NOUN
bjp-23604	50	4	postantibiotic	postantibiotic	ADJ
bjp-23604	50	5	effect	effect	NOUN
bjp-23604	50	6	of	of	ADP
bjp-23604	50	7	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	50	8	was	be	AUX
bjp-23604	50	9	determined	determine	VERB
bjp-23604	50	10	using	use	VERB
bjp-23604	50	11	methodology	methodology	NOUN
bjp-23604	50	12	described	describe	VERB
bjp-23604	50	13	previously	previously	ADV
bjp-23604	50	14	(	(	PUNCT
bjp-23604	50	15	spangler	spangler	PROPN
bjp-23604	50	16	et	et	PROPN
bjp-23604	50	17	al	al	PROPN
bjp-23604	50	18	.	.	PROPN
bjp-23604	50	19	,	,	PUNCT
bjp-23604	50	20	1998	1998	NUM
bjp-23604	50	21	)	)	PUNCT
bjp-23604	50	22	.	.	PUNCT
bjp-23604	51	1	tubes	tube	NOUN
bjp-23604	51	2	were	be	AUX
bjp-23604	51	3	filled	fill	VERB
bjp-23604	51	4	to	to	ADP
bjp-23604	51	5	a	a	DET
bjp-23604	51	6	final	final	ADJ
bjp-23604	51	7	volume	volume	NOUN
bjp-23604	51	8	of	of	ADP
bjp-23604	51	9	5	5	NUM
bjp-23604	51	10	ml	ml	NOUN
bjp-23604	51	11	with	with	ADP
bjp-23604	51	12	0.5	0.5	NUM
bjp-23604	51	13	ml	ml	NOUN
bjp-23604	51	14	bacterial	bacterial	ADJ
bjp-23604	51	15	suspension	suspension	NOUN
bjp-23604	51	16	,	,	PUNCT
bjp-23604	51	17	4.4	4.4	NUM
bjp-23604	51	18	ml	ml	NOUN
bjp-23604	51	19	of	of	ADP
bjp-23604	51	20	muellerhinton	muellerhinton	NOUN
bjp-23604	51	21	broth	broth	NOUN
bjp-23604	51	22	and	and	CCONJ
bjp-23604	51	23	0.1	0.1	NUM
bjp-23604	51	24	ml	ml	NOUN
bjp-23604	51	25	of	of	ADP
bjp-23604	51	26	previously	previously	ADV
bjp-23604	51	27	prepared	prepare	VERB
bjp-23604	51	28	saline	saline	NOUN
bjp-23604	51	29	and	and	CCONJ
bjp-23604	51	30	antibiotic	antibiotic	ADJ
bjp-23604	51	31	mixture	mixture	NOUN
bjp-23604	51	32	(	(	PUNCT
bjp-23604	51	33	only	only	ADV
bjp-23604	51	34	0.1	0.1	NUM
bjp-23604	51	35	ml	ml	NOUN
bjp-23604	51	36	saline	saline	ADJ
bjp-23604	51	37	solution	solution	NOUN
bjp-23604	51	38	was	be	AUX
bjp-23604	51	39	added	add	VERB
bjp-23604	51	40	to	to	ADP
bjp-23604	51	41	the	the	DET
bjp-23604	51	42	negative	negative	ADJ
bjp-23604	51	43	controls	control	NOUN
bjp-23604	51	44	)	)	PUNCT
bjp-23604	51	45	.	.	PUNCT
bjp-23604	52	1	bacteria	bacteria	NOUN
bjp-23604	52	2	were	be	AUX
bjp-23604	52	3	subjected	subject	VERB
bjp-23604	52	4	to	to	ADP
bjp-23604	52	5	the	the	DET
bjp-23604	52	6	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	52	7	concentration	concentration	NOUN
bjp-23604	52	8	of	of	ADP
bjp-23604	52	9	½×	½×	ADJ
bjp-23604	52	10	mic	mic	NOUN
bjp-23604	52	11	,	,	PUNCT
bjp-23604	52	12	1×	1×	NUM
bjp-23604	52	13	mic	mic	NOUN
bjp-23604	52	14	and	and	CCONJ
bjp-23604	52	15	4	4	NUM
bjp-23604	52	16	×	×	NOUN
bjp-23604	52	17	mic	mic	NOUN
bjp-23604	52	18	.	.	PUNCT
bjp-23604	53	1	the	the	DET
bjp-23604	53	2	final	final	ADJ
bjp-23604	53	3	inoculum	inoculum	NOUN
bjp-23604	53	4	was	be	AUX
bjp-23604	53	5	106	106	NUM
bjp-23604	53	6	to	to	ADP
bjp-23604	53	7	107	107	NUM
bjp-23604	54	1	cfu/	cfu/	VERB
bjp-23604	54	2	ml	ml	NOUN
bjp-23604	54	3	.	.	PUNCT
bjp-23604	54	4	control	control	NOUN
bjp-23604	54	5	tubes	tube	NOUN
bjp-23604	54	6	and	and	CCONJ
bjp-23604	54	7	antibiotic	antibiotic	NOUN
bjp-23604	54	8	-	-	PUNCT
bjp-23604	54	9	containing	contain	VERB
bjp-23604	54	10	tubes	tube	NOUN
bjp-23604	54	11	were	be	AUX
bjp-23604	54	12	incubated	incubate	VERB
bjp-23604	54	13	in	in	ADP
bjp-23604	54	14	a	a	DET
bjp-23604	54	15	37	37	NUM
bjp-23604	54	16	°	°	NOUN
bjp-23604	54	17	c	c	NOUN
bjp-23604	54	18	water	water	NOUN
bjp-23604	54	19	bath	bath	NOUN
bjp-23604	54	20	.	.	PUNCT
bjp-23604	55	1	the	the	DET
bjp-23604	55	2	time	time	NOUN
bjp-23604	55	3	of	of	ADP
bjp-23604	55	4	antibiotic	antibiotic	ADJ
bjp-23604	55	5	exposure	exposure	NOUN
bjp-23604	55	6	was	be	AUX
bjp-23604	55	7	1	1	NUM
bjp-23604	55	8	hour	hour	NOUN
bjp-23604	55	9	and	and	CCONJ
bjp-23604	55	10	2	2	NUM
bjp-23604	55	11	hours	hour	NOUN
bjp-23604	55	12	.	.	PUNCT
bjp-23604	56	1	after	after	ADP
bjp-23604	56	2	the	the	DET
bjp-23604	56	3	incubation	incubation	NOUN
bjp-23604	56	4	time	time	NOUN
bjp-23604	56	5	,	,	PUNCT
bjp-23604	56	6	antibiotics	antibiotic	NOUN
bjp-23604	56	7	were	be	AUX
bjp-23604	56	8	removed	remove	VERB
bjp-23604	56	9	using	use	VERB
bjp-23604	56	10	dilution	dilution	NOUN
bjp-23604	56	11	method	method	NOUN
bjp-23604	56	12	(	(	PUNCT
bjp-23604	56	13	1	1	NUM
bjp-23604	56	14	:	:	SYM
bjp-23604	56	15	1000	1000	NUM
bjp-23604	56	16	-	-	SYM
bjp-23604	56	17	10000	10000	NUM
bjp-23604	56	18	)	)	PUNCT
bjp-23604	56	19	with	with	ADP
bjp-23604	56	20	antibiotic	antibiotic	ADJ
bjp-23604	56	21	free	free	ADJ
bjp-23604	56	22	broth	broth	NOUN
bjp-23604	56	23	.	.	PUNCT
bjp-23604	57	1	thereafter	thereafter	ADV
bjp-23604	57	2	,	,	PUNCT
bjp-23604	57	3	10μl	10μl	ADJ
bjp-23604	57	4	samples	sample	NOUN
bjp-23604	57	5	were	be	AUX
bjp-23604	57	6	plated	plate	VERB
bjp-23604	57	7	onto	onto	ADP
bjp-23604	57	8	the	the	DET
bjp-23604	57	9	surfaces	surface	NOUN
bjp-23604	57	10	of	of	ADP
bjp-23604	57	11	muellerhinton	muellerhinton	NOUN
bjp-23604	57	12	agar	agar	NOUN
bjp-23604	57	13	plates	plate	NOUN
bjp-23604	57	14	.	.	PUNCT
bjp-23604	58	1	this	this	PRON
bjp-23604	58	2	was	be	AUX
bjp-23604	58	3	defined	define	VERB
bjp-23604	58	4	as	as	ADP
bjp-23604	58	5	zero	zero	NUM
bjp-23604	58	6	time	time	NOUN
bjp-23604	58	7	after	after	ADP
bjp-23604	58	8	antibiotic	antibiotic	ADJ
bjp-23604	58	9	removal	removal	NOUN
bjp-23604	58	10	.	.	PUNCT
bjp-23604	59	1	diluted	dilute	VERB
bjp-23604	59	2	suspensions	suspension	NOUN
bjp-23604	59	3	of	of	ADP
bjp-23604	59	4	bacteria	bacteria	NOUN
bjp-23604	59	5	were	be	AUX
bjp-23604	59	6	further	far	ADV
bjp-23604	59	7	incubated	incubate	VERB
bjp-23604	59	8	at	at	ADP
bjp-23604	59	9	37	37	NUM
bjp-23604	59	10	°	°	ADP
bjp-23604	59	11	c	c	NOUN
bjp-23604	59	12	for	for	ADP
bjp-23604	59	13	6	6	NUM
bjp-23604	59	14	hours	hour	NOUN
bjp-23604	59	15	,	,	PUNCT
bjp-23604	59	16	and	and	CCONJ
bjp-23604	59	17	at	at	ADP
bjp-23604	59	18	622	622	NUM
bjp-23604	59	19	bangladesh	bangladesh	NOUN
bjp-23604	59	20	j	j	PROPN
bjp-23604	59	21	pharmacol	pharmacol	PROPN
bjp-23604	59	22	2015	2015	NUM
bjp-23604	59	23	;	;	PUNCT
bjp-23604	59	24	10	10	NUM
bjp-23604	59	25	:	:	SYM
bjp-23604	59	26	621	621	NUM
bjp-23604	59	27	-	-	SYM
bjp-23604	59	28	626	626	NUM
bjp-23604	59	29	hourly	hourly	ADJ
bjp-23604	59	30	intervals	interval	NOUN
bjp-23604	59	31	0.5	0.5	NUM
bjp-23604	59	32	ml	ml	NOUN
bjp-23604	59	33	was	be	AUX
bjp-23604	59	34	removed	remove	VERB
bjp-23604	59	35	and	and	CCONJ
bjp-23604	59	36	plated	plate	VERB
bjp-23604	59	37	onto	onto	ADP
bjp-23604	59	38	agar	agar	NOUN
bjp-23604	59	39	.	.	PUNCT
bjp-23604	60	1	a	a	DET
bjp-23604	60	2	control	control	NOUN
bjp-23604	60	3	,	,	PUNCT
bjp-23604	60	4	antibiotic	antibiotic	ADJ
bjp-23604	60	5	free	free	ADJ
bjp-23604	60	6	culture	culture	NOUN
bjp-23604	60	7	was	be	AUX
bjp-23604	60	8	handled	handle	VERB
bjp-23604	60	9	in	in	ADP
bjp-23604	60	10	the	the	DET
bjp-23604	60	11	same	same	ADJ
bjp-23604	60	12	manner	manner	NOUN
bjp-23604	60	13	.	.	PUNCT
bjp-23604	61	1	viability	viability	NOUN
bjp-23604	61	2	count	count	NOUN
bjp-23604	61	3	was	be	AUX
bjp-23604	61	4	used	use	VERB
bjp-23604	61	5	to	to	PART
bjp-23604	61	6	determine	determine	VERB
bjp-23604	61	7	and	and	CCONJ
bjp-23604	61	8	compare	compare	VERB
bjp-23604	61	9	the	the	DET
bjp-23604	61	10	growth	growth	NOUN
bjp-23604	61	11	kinetics	kinetic	NOUN
bjp-23604	61	12	of	of	ADP
bjp-23604	61	13	bacterial	bacterial	ADJ
bjp-23604	61	14	colonies	colony	NOUN
bjp-23604	61	15	exposed	expose	VERB
bjp-23604	61	16	to	to	ADP
bjp-23604	61	17	the	the	DET
bjp-23604	61	18	antibiotic	antibiotic	ADJ
bjp-23604	61	19	and	and	CCONJ
bjp-23604	61	20	negative	negative	ADJ
bjp-23604	61	21	control	control	NOUN
bjp-23604	61	22	group	group	NOUN
bjp-23604	61	23	and	and	CCONJ
bjp-23604	61	24	time	time	NOUN
bjp-23604	61	25	-	-	PUNCT
bjp-23604	61	26	growth	growth	NOUN
bjp-23604	61	27	curves	curve	NOUN
bjp-23604	61	28	were	be	AUX
bjp-23604	61	29	constructed	construct	VERB
bjp-23604	61	30	.	.	PUNCT
bjp-23604	62	1	the	the	DET
bjp-23604	62	2	number	number	NOUN
bjp-23604	62	3	of	of	ADP
bjp-23604	62	4	viable	viable	ADJ
bjp-23604	62	5	bacteria	bacteria	NOUN
bjp-23604	62	6	was	be	AUX
bjp-23604	62	7	determined	determine	VERB
bjp-23604	62	8	at	at	ADP
bjp-23604	62	9	zero	zero	NUM
bjp-23604	62	10	time	time	NOUN
bjp-23604	62	11	after	after	ADP
bjp-23604	62	12	the	the	DET
bjp-23604	62	13	antibiotic	antibiotic	ADJ
bjp-23604	62	14	removal	removal	NOUN
bjp-23604	62	15	and	and	CCONJ
bjp-23604	62	16	at	at	ADP
bjp-23604	62	17	hourly	hourly	ADJ
bjp-23604	62	18	intervals	interval	NOUN
bjp-23604	62	19	for	for	ADP
bjp-23604	62	20	next	next	ADJ
bjp-23604	62	21	6	6	NUM
bjp-23604	62	22	hours	hour	NOUN
bjp-23604	62	23	.	.	PUNCT
bjp-23604	63	1	the	the	DET
bjp-23604	63	2	pae	pae	NOUN
bjp-23604	63	3	was	be	AUX
bjp-23604	63	4	calculated	calculate	VERB
bjp-23604	63	5	with	with	ADP
bjp-23604	63	6	the	the	DET
bjp-23604	63	7	standard	standard	ADJ
bjp-23604	63	8	formula	formula	NOUN
bjp-23604	63	9	of	of	ADP
bjp-23604	63	10	craig	craig	PROPN
bjp-23604	63	11	and	and	CCONJ
bjp-23604	63	12	gudmundsson	gudmundsson	PROPN
bjp-23604	63	13	(	(	PUNCT
bjp-23604	63	14	craig	craig	PROPN
bjp-23604	63	15	and	and	CCONJ
bjp-23604	63	16	gudmundsson	gudmundsson	NOUN
bjp-23604	63	17	,	,	PUNCT
bjp-23604	63	18	1996	1996	NUM
bjp-23604	63	19	)	)	PUNCT
bjp-23604	63	20	,	,	PUNCT
bjp-23604	63	21	as	as	ADP
bjp-23604	63	22	a	a	DET
bjp-23604	63	23	difference	difference	NOUN
bjp-23604	63	24	in	in	ADP
bjp-23604	63	25	time	time	NOUN
bjp-23604	63	26	necessary	necessary	ADJ
bjp-23604	63	27	for	for	SCONJ
bjp-23604	63	28	the	the	DET
bjp-23604	63	29	colony	colony	NOUN
bjp-23604	63	30	forming	form	VERB
bjp-23604	63	31	units	unit	NOUN
bjp-23604	63	32	to	to	PART
bjp-23604	63	33	increase	increase	VERB
bjp-23604	63	34	10	10	NUM
bjp-23604	63	35	-	-	NOUN
bjp-23604	63	36	fold	fold	ADJ
bjp-23604	63	37	(	(	PUNCT
bjp-23604	63	38	desired	desire	VERB
bjp-23604	63	39	increase	increase	NOUN
bjp-23604	63	40	of	of	ADP
bjp-23604	63	41	1	1	NUM
bjp-23604	63	42	log10	log10	NOUN
bjp-23604	63	43	)	)	PUNCT
bjp-23604	63	44	between	between	ADP
bjp-23604	63	45	test	test	NOUN
bjp-23604	63	46	and	and	CCONJ
bjp-23604	63	47	control	control	NOUN
bjp-23604	63	48	cultures	culture	NOUN
bjp-23604	63	49	from	from	ADP
bjp-23604	63	50	the	the	DET
bjp-23604	63	51	count	count	NOUN
bjp-23604	63	52	observed	observe	VERB
bjp-23604	63	53	at	at	ADP
bjp-23604	63	54	zero	zero	NUM
bjp-23604	63	55	time	time	NOUN
bjp-23604	63	56	.	.	PUNCT
bjp-23604	64	1	a	a	DET
bjp-23604	64	2	10	10	NUM
bjp-23604	64	3	-	-	ADJ
bjp-23604	64	4	fold	fold	ADJ
bjp-23604	64	5	growth	growth	NOUN
bjp-23604	64	6	rate	rate	NOUN
bjp-23604	64	7	increase	increase	NOUN
bjp-23604	64	8	was	be	AUX
bjp-23604	64	9	arbitrarily	arbitrarily	ADV
bjp-23604	64	10	chosen	choose	VERB
bjp-23604	64	11	because	because	SCONJ
bjp-23604	64	12	beyond	beyond	ADP
bjp-23604	64	13	that	that	DET
bjp-23604	64	14	level	level	NOUN
bjp-23604	64	15	,	,	PUNCT
bjp-23604	64	16	the	the	DET
bjp-23604	64	17	rate	rate	NOUN
bjp-23604	64	18	of	of	ADP
bjp-23604	64	19	growth	growth	NOUN
bjp-23604	64	20	of	of	ADP
bjp-23604	64	21	the	the	DET
bjp-23604	64	22	organisms	organism	NOUN
bjp-23604	64	23	exposed	expose	VERB
bjp-23604	64	24	to	to	ADP
bjp-23604	64	25	the	the	DET
bjp-23604	64	26	antibiotic	antibiotic	NOUN
bjp-23604	64	27	is	be	AUX
bjp-23604	64	28	the	the	DET
bjp-23604	64	29	same	same	ADJ
bjp-23604	64	30	as	as	ADP
bjp-23604	64	31	that	that	PRON
bjp-23604	64	32	of	of	ADP
bjp-23604	64	33	the	the	DET
bjp-23604	64	34	untreated	untreated	ADJ
bjp-23604	64	35	controls	control	NOUN
bjp-23604	64	36	.	.	PUNCT
bjp-23604	65	1	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	65	2	/	/	SYM
bjp-23604	65	3	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	65	4	parameters	parameter	NOUN
bjp-23604	65	5	by	by	ADP
bjp-23604	65	6	using	use	VERB
bjp-23604	65	7	in	in	ADP
bjp-23604	65	8	vitro	vitro	X
bjp-23604	65	9	mic	mic	ADJ
bjp-23604	65	10	data	datum	NOUN
bjp-23604	65	11	and	and	CCONJ
bjp-23604	65	12	simulated	simulated	ADJ
bjp-23604	65	13	plasma	plasma	NOUN
bjp-23604	65	14	profiles	profile	NOUN
bjp-23604	65	15	,	,	PUNCT
bjp-23604	65	16	the	the	DET
bjp-23604	65	17	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	65	18	/	/	SYM
bjp-23604	65	19	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	65	20	markers	marker	NOUN
bjp-23604	65	21	of	of	ADP
bjp-23604	65	22	antimicrobial	antimicrobial	ADJ
bjp-23604	65	23	activity	activity	NOUN
bjp-23604	65	24	(	(	PUNCT
bjp-23604	65	25	auc	auc	NOUN
bjp-23604	65	26	/	/	SYM
bjp-23604	65	27	mic	mic	ADJ
bjp-23604	65	28	and	and	CCONJ
bjp-23604	65	29	cmax/	cmax/	NUM
bjp-23604	65	30	mic	mic	NOUN
bjp-23604	65	31	)	)	PUNCT
bjp-23604	65	32	were	be	AUX
bjp-23604	65	33	determined	determine	VERB
bjp-23604	65	34	.	.	PUNCT
bjp-23604	66	1	auc	auc	NOUN
bjp-23604	66	2	/	/	SYM
bjp-23604	66	3	mic	mic	ADJ
bjp-23604	66	4	and	and	CCONJ
bjp-23604	66	5	cmax	cmax	VERB
bjp-23604	66	6	/	/	SYM
bjp-23604	66	7	mic	mic	NOUN
bjp-23604	66	8	were	be	AUX
bjp-23604	66	9	calculated	calculate	VERB
bjp-23604	66	10	as	as	ADP
bjp-23604	66	11	the	the	DET
bjp-23604	66	12	area	area	NOUN
bjp-23604	66	13	under	under	ADP
bjp-23604	66	14	the	the	DET
bjp-23604	66	15	concentration	concentration	NOUN
bjp-23604	66	16	–	–	PUNCT
bjp-23604	66	17	time	time	NOUN
bjp-23604	66	18	curve	curve	NOUN
bjp-23604	66	19	or	or	CCONJ
bjp-23604	66	20	the	the	DET
bjp-23604	66	21	highest	high	ADJ
bjp-23604	66	22	concentration	concentration	NOUN
bjp-23604	66	23	reached	reach	VERB
bjp-23604	66	24	over	over	ADP
bjp-23604	66	25	24	24	NUM
bjp-23604	66	26	hours	hour	NOUN
bjp-23604	66	27	divided	divide	VERB
bjp-23604	66	28	by	by	ADP
bjp-23604	66	29	determined	determined	ADJ
bjp-23604	66	30	mic	mic	ADJ
bjp-23604	66	31	values	value	NOUN
bjp-23604	66	32	of	of	ADP
bjp-23604	66	33	tested	test	VERB
bjp-23604	66	34	pathogens	pathogen	NOUN
bjp-23604	66	35	.	.	PUNCT
bjp-23604	67	1	these	these	DET
bjp-23604	67	2	results	result	NOUN
bjp-23604	67	3	were	be	AUX
bjp-23604	67	4	incorporated	incorporate	VERB
bjp-23604	67	5	with	with	ADP
bjp-23604	67	6	postantibiotic	postantibiotic	ADJ
bjp-23604	67	7	effect	effect	NOUN
bjp-23604	67	8	duration	duration	NOUN
bjp-23604	67	9	,	,	PUNCT
bjp-23604	67	10	in	in	ADP
bjp-23604	67	11	order	order	NOUN
bjp-23604	67	12	to	to	PART
bjp-23604	67	13	fully	fully	ADV
bjp-23604	67	14	grasp	grasp	VERB
bjp-23604	67	15	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	67	16	profile	profile	NOUN
bjp-23604	67	17	of	of	ADP
bjp-23604	67	18	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	67	19	.	.	PUNCT
bjp-23604	68	1	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	68	2	/	/	SYM
bjp-23604	68	3	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	68	4	breakpoints	breakpoint	NOUN
bjp-23604	68	5	targeting	target	VERB
bjp-23604	68	6	desired	desire	VERB
bjp-23604	68	7	thresholds	threshold	NOUN
bjp-23604	68	8	of	of	ADP
bjp-23604	68	9	auc	auc	NOUN
bjp-23604	68	10	/	/	SYM
bjp-23604	68	11	mic	mic	NOUN
bjp-23604	68	12	of	of	ADP
bjp-23604	68	13	125	125	NUM
bjp-23604	68	14	(	(	PUNCT
bjp-23604	68	15	forest	forest	NOUN
bjp-23604	68	16	et	et	PROPN
bjp-23604	68	17	al	al	PROPN
bjp-23604	68	18	.	.	PROPN
bjp-23604	68	19	,	,	PUNCT
bjp-23604	68	20	1993	1993	NUM
bjp-23604	68	21	)	)	PUNCT
bjp-23604	68	22	and	and	CCONJ
bjp-23604	68	23	cmax	cmax	VERB
bjp-23604	68	24	/	/	SYM
bjp-23604	68	25	mic	mic	NOUN
bjp-23604	68	26	of	of	ADP
bjp-23604	68	27	10	10	NUM
bjp-23604	68	28	(	(	PUNCT
bjp-23604	68	29	drusano	drusano	PROPN
bjp-23604	68	30	et	et	PROPN
bjp-23604	68	31	al	al	PROPN
bjp-23604	68	32	.	.	PROPN
bjp-23604	68	33	,	,	PUNCT
bjp-23604	68	34	2004	2004	NUM
bjp-23604	68	35	)	)	PUNCT
bjp-23604	68	36	have	have	AUX
bjp-23604	68	37	also	also	ADV
bjp-23604	68	38	been	be	AUX
bjp-23604	68	39	determined	determine	VERB
bjp-23604	68	40	.	.	PUNCT
bjp-23604	69	1	these	these	DET
bjp-23604	69	2	breakpoints	breakpoint	NOUN
bjp-23604	69	3	represent	represent	VERB
bjp-23604	69	4	the	the	DET
bjp-23604	69	5	highest	high	ADJ
bjp-23604	69	6	mic	mic	NOUN
bjp-23604	69	7	in	in	ADP
bjp-23604	69	8	which	which	PRON
bjp-23604	69	9	the	the	DET
bjp-23604	69	10	target	target	NOUN
bjp-23604	69	11	pharmacokinetic/	pharmacokinetic/	NUM
bjp-23604	69	12	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	69	13	indices	index	NOUN
bjp-23604	69	14	values	value	NOUN
bjp-23604	69	15	would	would	AUX
bjp-23604	69	16	be	be	AUX
bjp-23604	69	17	reached	reach	VERB
bjp-23604	69	18	with	with	ADP
bjp-23604	69	19	tested	test	VERB
bjp-23604	69	20	dosing	dose	VERB
bjp-23604	69	21	regimens	regimen	NOUN
bjp-23604	69	22	.	.	PUNCT
bjp-23604	70	1	results	result	NOUN
bjp-23604	70	2	figure	figure	VERB
bjp-23604	70	3	1	1	NUM
bjp-23604	70	4	shows	show	VERB
bjp-23604	70	5	simulated	simulate	VERB
bjp-23604	70	6	plasma	plasma	NOUN
bjp-23604	70	7	curves	curve	NOUN
bjp-23604	70	8	corresponding	correspond	VERB
bjp-23604	70	9	to	to	PART
bjp-23604	70	10	dosage	dosage	VERB
bjp-23604	70	11	regimens	regimen	NOUN
bjp-23604	70	12	of	of	ADP
bjp-23604	70	13	500	500	NUM
bjp-23604	70	14	mg/12	mg/12	PROPN
bjp-23604	70	15	hours	hour	NOUN
bjp-23604	70	16	and	and	CCONJ
bjp-23604	70	17	750	750	NUM
bjp-23604	70	18	mg/12	mg/12	PROPN
bjp-23604	70	19	hours	hour	NOUN
bjp-23604	70	20	of	of	ADP
bjp-23604	70	21	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	70	22	for	for	ADP
bjp-23604	70	23	patients	patient	NOUN
bjp-23604	70	24	with	with	ADP
bjp-23604	70	25	standard	standard	ADJ
bjp-23604	70	26	weight	weight	NOUN
bjp-23604	70	27	of	of	ADP
bjp-23604	70	28	70	70	NUM
bjp-23604	70	29	kg	kg	NOUN
bjp-23604	70	30	.	.	PUNCT
bjp-23604	71	1	the	the	DET
bjp-23604	71	2	mic	mic	NOUN
bjp-23604	71	3	determined	determine	VERB
bjp-23604	71	4	for	for	ADP
bjp-23604	71	5	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	71	6	on	on	ADP
bjp-23604	71	7	different	different	ADJ
bjp-23604	71	8	bacterial	bacterial	ADJ
bjp-23604	71	9	strains	strain	NOUN
bjp-23604	71	10	ranged	range	VERB
bjp-23604	71	11	from	from	ADP
bjp-23604	71	12	0.0156	0.0156	NUM
bjp-23604	71	13	µg	µg	NOUN
bjp-23604	71	14	/	/	SYM
bjp-23604	71	15	ml	ml	X
bjp-23604	71	16	for	for	ADP
bjp-23604	71	17	escherichia	escherichia	NOUN
bjp-23604	71	18	coli	coli	NOUN
bjp-23604	71	19	and	and	CCONJ
bjp-23604	71	20	proteus	proteus	PROPN
bjp-23604	71	21	mirabilis	mirabilis	PROPN
bjp-23604	71	22	,	,	PUNCT
bjp-23604	71	23	0.125	0.125	NUM
bjp-23604	71	24	µg	µg	NOUN
bjp-23604	71	25	/	/	SYM
bjp-23604	71	26	ml	ml	X
bjp-23604	71	27	for	for	ADP
bjp-23604	71	28	s.	s.	PROPN
bjp-23604	71	29	aureus	aureus	PROPN
bjp-23604	71	30	to	to	ADP
bjp-23604	71	31	0.5	0.5	NUM
bjp-23604	71	32	µg	µg	NOUN
bjp-23604	71	33	/	/	SYM
bjp-23604	71	34	ml	ml	X
bjp-23604	71	35	for	for	ADP
bjp-23604	71	36	s.	s.	PROPN
bjp-23604	71	37	epidermidis	epidermidis	PROPN
bjp-23604	71	38	.	.	PUNCT
bjp-23604	72	1	table	table	NOUN
bjp-23604	72	2	i	i	PRON
bjp-23604	72	3	shows	show	VERB
bjp-23604	72	4	table	table	NOUN
bjp-23604	72	5	i	i	PRON
bjp-23604	72	6	postantibiotic	postantibiotic	ADJ
bjp-23604	72	7	effect	effect	NOUN
bjp-23604	72	8	induced	induce	VERB
bjp-23604	72	9	by	by	ADP
bjp-23604	72	10	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	72	11	on	on	ADP
bjp-23604	72	12	different	different	ADJ
bjp-23604	72	13	bacterial	bacterial	ADJ
bjp-23604	72	14	strains	strain	NOUN
bjp-23604	72	15	incubation	incubation	NOUN
bjp-23604	72	16	time	time	NOUN
bjp-23604	72	17	antibiotic	antibiotic	ADJ
bjp-23604	72	18	concentration	concentration	NOUN
bjp-23604	72	19	duration	duration	NOUN
bjp-23604	72	20	of	of	ADP
bjp-23604	72	21	postantibiotic	postantibiotic	ADJ
bjp-23604	72	22	effect	effect	NOUN
bjp-23604	72	23	(	(	PUNCT
bjp-23604	72	24	hour	hour	NOUN
bjp-23604	72	25	)	)	PUNCT
bjp-23604	72	26	escherichia	escherichia	NOUN
bjp-23604	72	27	coli	coli	NOUN
bjp-23604	72	28	proteus	proteus	NOUN
bjp-23604	72	29	mirabilis	mirabilis	PROPN
bjp-23604	72	30	staphylococcus	staphylococcus	NOUN
bjp-23604	72	31	epidermidis	epidermidis	PROPN
bjp-23604	72	32	staphylococcus	staphylococcus	NOUN
bjp-23604	72	33	aureus	aureus	NOUN
bjp-23604	72	34	1	1	NUM
bjp-23604	72	35	hours	hour	NOUN
bjp-23604	72	36	½	½	NOUN
bjp-23604	72	37	mic	mic	NOUN
bjp-23604	72	38	0.75	0.75	NUM
bjp-23604	72	39	0.50	0.50	NUM
bjp-23604	72	40	0.48	0.48	NUM
bjp-23604	72	41	0.50	0.50	NUM
bjp-23604	72	42	1	1	NUM
bjp-23604	72	43	mic	mic	NOUN
bjp-23604	72	44	0.83	0.83	NUM
bjp-23604	72	45	0.78	0.78	NUM
bjp-23604	72	46	0.65	0.65	NUM
bjp-23604	72	47	0.53	0.53	NUM
bjp-23604	72	48	4	4	NUM
bjp-23604	72	49	mic	mic	ADJ
bjp-23604	72	50	0.93	0.93	NUM
bjp-23604	72	51	1.23	1.23	NUM
bjp-23604	72	52	1.42	1.42	NUM
bjp-23604	72	53	1.35	1.35	NUM
bjp-23604	72	54	½	½	NOUN
bjp-23604	72	55	mic	mic	ADJ
bjp-23604	72	56	0.90	0.90	NUM
bjp-23604	72	57	0.83	0.83	NUM
bjp-23604	72	58	1.68	1.68	NUM
bjp-23604	72	59	0.65	0.65	NUM
bjp-23604	72	60	2	2	NUM
bjp-23604	72	61	hours	hour	NOUN
bjp-23604	72	62	1	1	NUM
bjp-23604	72	63	mic	mic	NOUN
bjp-23604	72	64	1.08	1.08	NUM
bjp-23604	72	65	1.07	1.07	NUM
bjp-23604	72	66	1.83	1.83	NUM
bjp-23604	72	67	0.93	0.93	NUM
bjp-23604	72	68	4	4	NUM
bjp-23604	72	69	mic	mic	ADJ
bjp-23604	72	70	2.20	2.20	NUM
bjp-23604	72	71	2.13	2.13	NUM
bjp-23604	72	72	2.60	2.60	NUM
bjp-23604	72	73	2.18	2.18	NUM
bjp-23604	72	74	bangladesh	bangladesh	PROPN
bjp-23604	72	75	j	j	PROPN
bjp-23604	72	76	pharmacol	pharmacol	PROPN
bjp-23604	72	77	2015	2015	NUM
bjp-23604	72	78	;	;	PUNCT
bjp-23604	72	79	10	10	NUM
bjp-23604	72	80	:	:	SYM
bjp-23604	72	81	621	621	NUM
bjp-23604	72	82	-	-	SYM
bjp-23604	72	83	626	626	NUM
bjp-23604	72	84	623	623	NUM
bjp-23604	72	85	figure	figure	NOUN
bjp-23604	72	86	1	1	NUM
bjp-23604	72	87	:	:	PUNCT
bjp-23604	72	88	simulated	simulate	VERB
bjp-23604	72	89	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	72	90	concentrations	concentration	NOUN
bjp-23604	72	91	in	in	ADP
bjp-23604	72	92	plasma	plasma	NOUN
bjp-23604	72	93	for	for	ADP
bjp-23604	72	94	the	the	DET
bjp-23604	72	95	dosage	dosage	NOUN
bjp-23604	72	96	regimens	regimen	NOUN
bjp-23604	72	97	of	of	ADP
bjp-23604	72	98	500	500	NUM
bjp-23604	72	99	mg/12	mg/12	PROPN
bjp-23604	72	100	hourly	hourly	ADJ
bjp-23604	72	101	and	and	CCONJ
bjp-23604	72	102	750	750	NUM
bjp-23604	72	103	mg/12	mg/12	PROPN
bjp-23604	72	104	hourly	hourly	ADJ
bjp-23604	72	105	duration	duration	NOUN
bjp-23604	72	106	of	of	ADP
bjp-23604	72	107	postantibiotic	postantibiotic	ADJ
bjp-23604	72	108	effect	effect	NOUN
bjp-23604	72	109	induced	induce	VERB
bjp-23604	72	110	by	by	ADP
bjp-23604	72	111	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	72	112	on	on	ADP
bjp-23604	72	113	different	different	ADJ
bjp-23604	72	114	bacterial	bacterial	ADJ
bjp-23604	72	115	strains	strain	NOUN
bjp-23604	72	116	.	.	PUNCT
bjp-23604	73	1	positive	positive	ADJ
bjp-23604	73	2	postantibiotic	postantibiotic	ADJ
bjp-23604	73	3	effect	effect	NOUN
bjp-23604	73	4	was	be	AUX
bjp-23604	73	5	found	find	VERB
bjp-23604	73	6	for	for	ADP
bjp-23604	73	7	all	all	DET
bjp-23604	73	8	isolates	isolate	NOUN
bjp-23604	73	9	subjected	subject	VERB
bjp-23604	73	10	to	to	ADP
bjp-23604	73	11	the	the	DET
bjp-23604	73	12	effect	effect	NOUN
bjp-23604	73	13	of	of	ADP
bjp-23604	73	14	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	73	15	.	.	PUNCT
bjp-23604	74	1	postantibiotic	postantibiotic	ADJ
bjp-23604	74	2	effect	effect	NOUN
bjp-23604	74	3	duration	duration	NOUN
bjp-23604	74	4	varied	varied	ADJ
bjp-23604	74	5	between	between	ADP
bjp-23604	74	6	different	different	ADJ
bjp-23604	74	7	bacterial	bacterial	ADJ
bjp-23604	74	8	strains	strain	NOUN
bjp-23604	74	9	,	,	PUNCT
bjp-23604	74	10	as	as	ADV
bjp-23604	74	11	well	well	ADV
bjp-23604	74	12	as	as	ADP
bjp-23604	74	13	between	between	ADP
bjp-23604	74	14	different	different	ADJ
bjp-23604	74	15	concentrations	concentration	NOUN
bjp-23604	74	16	and	and	CCONJ
bjp-23604	74	17	exposure	exposure	NOUN
bjp-23604	74	18	times	time	NOUN
bjp-23604	74	19	.	.	PUNCT
bjp-23604	75	1	for	for	ADP
bjp-23604	75	2	these	these	DET
bjp-23604	75	3	isolates	isolate	NOUN
bjp-23604	75	4	,	,	PUNCT
bjp-23604	75	5	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	75	6	induced	induce	VERB
bjp-23604	75	7	postantibiotic	postantibiotic	ADJ
bjp-23604	75	8	effect	effect	NOUN
bjp-23604	75	9	ranging	range	VERB
bjp-23604	75	10	from	from	ADP
bjp-23604	75	11	0.48	0.48	NUM
bjp-23604	75	12	2.60	2.60	NUM
bjp-23604	75	13	hours	hour	NOUN
bjp-23604	75	14	for	for	ADP
bjp-23604	75	15	gram	gram	NOUN
bjp-23604	75	16	positive	positive	ADJ
bjp-23604	75	17	strains	strain	NOUN
bjp-23604	75	18	,	,	PUNCT
bjp-23604	75	19	and	and	CCONJ
bjp-23604	75	20	from	from	ADP
bjp-23604	75	21	0.50	0.50	NUM
bjp-23604	75	22	–	–	PUNCT
bjp-23604	75	23	2.30	2.30	NUM
bjp-23604	75	24	hours	hour	NOUN
bjp-23604	75	25	for	for	ADP
bjp-23604	75	26	gram	gram	NOUN
bjp-23604	75	27	negative	negative	ADJ
bjp-23604	75	28	strains	strain	NOUN
bjp-23604	75	29	.	.	PUNCT
bjp-23604	76	1	integrated	integrate	VERB
bjp-23604	76	2	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	76	3	/	/	SYM
bjp-23604	76	4	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	76	5	parameters	parameter	NOUN
bjp-23604	76	6	for	for	ADP
bjp-23604	76	7	the	the	DET
bjp-23604	76	8	simulated	simulate	VERB
bjp-23604	76	9	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	76	10	data	datum	NOUN
bjp-23604	76	11	and	and	CCONJ
bjp-23604	76	12	the	the	DET
bjp-23604	76	13	mic	mic	NOUN
bjp-23604	76	14	measured	measure	VERB
bjp-23604	76	15	in	in	ADP
bjp-23604	76	16	vitro	vitro	X
bjp-23604	76	17	are	be	AUX
bjp-23604	76	18	displayed	display	VERB
bjp-23604	76	19	in	in	ADP
bjp-23604	76	20	table	table	NOUN
bjp-23604	76	21	ii	ii	PROPN
bjp-23604	76	22	.	.	PUNCT
bjp-23604	77	1	dosing	dose	VERB
bjp-23604	77	2	regimens	regimen	NOUN
bjp-23604	77	3	of	of	ADP
bjp-23604	77	4	500	500	NUM
bjp-23604	77	5	mg/12	mg/12	PROPN
bjp-23604	77	6	hours	hour	NOUN
bjp-23604	77	7	and	and	CCONJ
bjp-23604	77	8	750	750	NUM
bjp-23604	77	9	mg/12	mg/12	PROPN
bjp-23604	77	10	hours	hour	NOUN
bjp-23604	77	11	produced	produce	VERB
bjp-23604	77	12	variable	variable	ADJ
bjp-23604	77	13	auc	auc	NOUN
bjp-23604	77	14	/	/	SYM
bjp-23604	77	15	mic	mic	ADJ
bjp-23604	77	16	and	and	CCONJ
bjp-23604	77	17	cmax	cmax	VERB
bjp-23604	77	18	/	/	SYM
bjp-23604	77	19	mic	mic	ADJ
bjp-23604	77	20	values	value	NOUN
bjp-23604	77	21	.	.	PUNCT
bjp-23604	78	1	both	both	DET
bjp-23604	78	2	regimens	regimen	NOUN
bjp-23604	78	3	were	be	AUX
bjp-23604	78	4	equally	equally	ADV
bjp-23604	78	5	efficient	efficient	ADJ
bjp-23604	78	6	,	,	PUNCT
bjp-23604	78	7	with	with	ADP
bjp-23604	78	8	values	value	NOUN
bjp-23604	78	9	high	high	ADV
bjp-23604	78	10	above	above	ADV
bjp-23604	78	11	desired	desire	VERB
bjp-23604	78	12	range	range	NOUN
bjp-23604	78	13	on	on	ADP
bjp-23604	78	14	microorganisms	microorganism	NOUN
bjp-23604	78	15	with	with	ADP
bjp-23604	78	16	lowest	low	ADJ
bjp-23604	78	17	mic	mic	NOUN
bjp-23604	78	18	(	(	PUNCT
bjp-23604	78	19	e.	e.	PROPN
bjp-23604	78	20	colli	colli	PROPN
bjp-23604	78	21	and	and	CCONJ
bjp-23604	78	22	p.	p.	PROPN
bjp-23604	78	23	mirabillis	mirabillis	PROPN
bjp-23604	78	24	)	)	PUNCT
bjp-23604	78	25	,	,	PUNCT
bjp-23604	78	26	while	while	SCONJ
bjp-23604	78	27	neither	neither	CCONJ
bjp-23604	78	28	were	be	VERB
bjp-23604	78	29	sufficient	sufficient	ADJ
bjp-23604	78	30	for	for	ADP
bjp-23604	78	31	s.	s.	PROPN
bjp-23604	78	32	epidermidis	epidermidis	PROPN
bjp-23604	78	33	,	,	PUNCT
bjp-23604	78	34	with	with	ADP
bjp-23604	78	35	mic	mic	NOUN
bjp-23604	78	36	of	of	ADP
bjp-23604	78	37	0.5	0.5	NUM
bjp-23604	78	38	µg/	µg/	NOUN
bjp-23604	78	39	ml	ml	NOUN
bjp-23604	78	40	.	.	PUNCT
bjp-23604	79	1	for	for	ADP
bjp-23604	79	2	s.	s.	PROPN
bjp-23604	79	3	aureus	aureus	PROPN
bjp-23604	79	4	,	,	PUNCT
bjp-23604	79	5	500	500	NUM
bjp-23604	79	6	mg/12	mg/12	PROPN
bjp-23604	79	7	hours	hour	NOUN
bjp-23604	79	8	dosing	dose	VERB
bjp-23604	79	9	regimen	regiman	NOUN
bjp-23604	79	10	comes	come	VERB
bjp-23604	79	11	close	close	ADV
bjp-23604	79	12	to	to	PART
bjp-23604	79	13	target	target	VERB
bjp-23604	79	14	values	value	NOUN
bjp-23604	79	15	,	,	PUNCT
bjp-23604	79	16	while	while	SCONJ
bjp-23604	79	17	750	750	NUM
bjp-23604	79	18	mg/12	mg/12	PROPN
bjp-23604	79	19	hours	hour	NOUN
bjp-23604	79	20	produces	produce	VERB
bjp-23604	79	21	values	value	NOUN
bjp-23604	79	22	sufficiently	sufficiently	ADV
bjp-23604	79	23	high	high	ADJ
bjp-23604	79	24	for	for	ADP
bjp-23604	79	25	eradication	eradication	NOUN
bjp-23604	79	26	of	of	ADP
bjp-23604	79	27	this	this	DET
bjp-23604	79	28	microorganism	microorganism	NOUN
bjp-23604	79	29	.	.	PUNCT
bjp-23604	80	1	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	80	2	/	/	SYM
bjp-23604	80	3	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	80	4	breakpoints	breakpoint	NOUN
bjp-23604	80	5	,	,	PUNCT
bjp-23604	80	6	which	which	PRON
bjp-23604	80	7	illustrate	illustrate	VERB
bjp-23604	80	8	the	the	DET
bjp-23604	80	9	mic	mic	ADJ
bjp-23604	80	10	values	value	NOUN
bjp-23604	80	11	for	for	ADP
bjp-23604	80	12	which	which	PRON
bjp-23604	80	13	main	main	ADJ
bjp-23604	80	14	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	80	15	/	/	SYM
bjp-23604	80	16	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	80	17	ratios	ratio	NOUN
bjp-23604	80	18	reach	reach	VERB
bjp-23604	80	19	values	value	NOUN
bjp-23604	80	20	required	require	VERB
bjp-23604	80	21	for	for	ADP
bjp-23604	80	22	clinical	clinical	ADJ
bjp-23604	80	23	success	success	NOUN
bjp-23604	80	24	(	(	PUNCT
bjp-23604	80	25	jacobs	jacobs	PROPN
bjp-23604	80	26	,	,	PUNCT
bjp-23604	80	27	2001	2001	NUM
bjp-23604	80	28	)	)	PUNCT
bjp-23604	80	29	were	be	AUX
bjp-23604	80	30	in	in	ADP
bjp-23604	80	31	range	range	NOUN
bjp-23604	80	32	of	of	ADP
bjp-23604	80	33	0.1	0.1	NUM
bjp-23604	80	34	-	-	SYM
bjp-23604	80	35	0.2	0.2	NUM
bjp-23604	80	36	µg	µg	NOUN
bjp-23604	80	37	/	/	SYM
bjp-23604	80	38	ml	ml	NOUN
bjp-23604	80	39	.	.	PUNCT
bjp-23604	81	1	discussion	discussion	NOUN
bjp-23604	81	2	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	81	3	are	be	AUX
bjp-23604	81	4	often	often	ADV
bjp-23604	81	5	used	use	VERB
bjp-23604	81	6	as	as	ADP
bjp-23604	81	7	the	the	DET
bjp-23604	81	8	drugs	drug	NOUN
bjp-23604	81	9	of	of	ADP
bjp-23604	81	10	choice	choice	NOUN
bjp-23604	81	11	for	for	ADP
bjp-23604	81	12	the	the	DET
bjp-23604	81	13	empirical	empirical	ADJ
bjp-23604	81	14	treatment	treatment	NOUN
bjp-23604	81	15	of	of	ADP
bjp-23604	81	16	uncomplicated	uncomplicated	ADJ
bjp-23604	81	17	and	and	CCONJ
bjp-23604	81	18	complicated	complicated	ADJ
bjp-23604	81	19	urinary	urinary	ADJ
bjp-23604	81	20	tract	tract	NOUN
bjp-23604	81	21	infections	infection	NOUN
bjp-23604	81	22	.	.	PUNCT
bjp-23604	82	1	a	a	DET
bjp-23604	82	2	10	10	NUM
bjp-23604	82	3	-	-	PUNCT
bjp-23604	82	4	day	day	NOUN
bjp-23604	82	5	course	course	NOUN
bjp-23604	82	6	of	of	ADP
bjp-23604	82	7	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	82	8	is	be	AUX
bjp-23604	82	9	recommended	recommend	VERB
bjp-23604	82	10	for	for	ADP
bjp-23604	82	11	patients	patient	NOUN
bjp-23604	82	12	with	with	ADP
bjp-23604	82	13	complicated	complicated	ADJ
bjp-23604	82	14	urinary	urinary	ADJ
bjp-23604	82	15	tract	tract	NOUN
bjp-23604	82	16	infections	infection	NOUN
bjp-23604	82	17	or	or	CCONJ
bjp-23604	82	18	acute	acute	NOUN
bjp-23604	82	19	pyelonephritis	pyelonephritis	NOUN
bjp-23604	82	20	,	,	PUNCT
bjp-23604	82	21	if	if	SCONJ
bjp-23604	82	22	the	the	DET
bjp-23604	82	23	causative	causative	ADJ
bjp-23604	82	24	uropathogen	uropathogen	NOUN
bjp-23604	82	25	is	be	AUX
bjp-23604	82	26	susceptible	susceptible	ADJ
bjp-23604	82	27	(	(	PUNCT
bjp-23604	82	28	chen	chen	PROPN
bjp-23604	82	29	et	et	PROPN
bjp-23604	82	30	al	al	PROPN
bjp-23604	82	31	.	.	PROPN
bjp-23604	82	32	,	,	PUNCT
bjp-23604	82	33	2013	2013	NUM
bjp-23604	82	34	)	)	PUNCT
bjp-23604	82	35	.	.	PUNCT
bjp-23604	83	1	though	though	SCONJ
bjp-23604	83	2	usually	usually	ADV
bjp-23604	83	3	successfully	successfully	ADV
bjp-23604	83	4	treated	treat	VERB
bjp-23604	83	5	with	with	ADP
bjp-23604	83	6	antibiotics	antibiotic	NOUN
bjp-23604	83	7	,	,	PUNCT
bjp-23604	83	8	complicated	complicated	ADJ
bjp-23604	83	9	urinary	urinary	ADJ
bjp-23604	83	10	tract	tract	NOUN
bjp-23604	83	11	infections	infection	NOUN
bjp-23604	83	12	are	be	AUX
bjp-23604	83	13	often	often	ADV
bjp-23604	83	14	incompletely	incompletely	ADV
bjp-23604	83	15	resolved	resolve	VERB
bjp-23604	83	16	by	by	ADP
bjp-23604	83	17	antibiotic	antibiotic	ADJ
bjp-23604	83	18	therapy	therapy	NOUN
bjp-23604	83	19	and	and	CCONJ
bjp-23604	83	20	frequently	frequently	ADV
bjp-23604	83	21	recur	recur	VERB
bjp-23604	83	22	either	either	CCONJ
bjp-23604	83	23	through	through	ADP
bjp-23604	83	24	relapse	relapse	NOUN
bjp-23604	83	25	or	or	CCONJ
bjp-23604	83	26	recurrent	recurrent	ADJ
bjp-23604	83	27	infection	infection	NOUN
bjp-23604	83	28	(	(	PUNCT
bjp-23604	83	29	barber	barber	PROPN
bjp-23604	83	30	et	et	PROPN
bjp-23604	83	31	al	al	PROPN
bjp-23604	83	32	.	.	PROPN
bjp-23604	83	33	,	,	PUNCT
bjp-23604	83	34	2013	2013	NUM
bjp-23604	83	35	)	)	PUNCT
bjp-23604	83	36	.	.	PUNCT
bjp-23604	84	1	as	as	SCONJ
bjp-23604	84	2	stated	state	VERB
bjp-23604	84	3	before	before	ADV
bjp-23604	84	4	,	,	PUNCT
bjp-23604	84	5	for	for	ADP
bjp-23604	84	6	the	the	DET
bjp-23604	84	7	optimal	optimal	ADJ
bjp-23604	84	8	clinical	clinical	ADJ
bjp-23604	84	9	outcome	outcome	NOUN
bjp-23604	84	10	,	,	PUNCT
bjp-23604	84	11	high	high	ADJ
bjp-23604	84	12	concentrations	concentration	NOUN
bjp-23604	84	13	at	at	ADP
bjp-23604	84	14	the	the	DET
bjp-23604	84	15	site	site	NOUN
bjp-23604	84	16	of	of	ADP
bjp-23604	84	17	the	the	DET
bjp-23604	84	18	infection	infection	NOUN
bjp-23604	84	19	are	be	AUX
bjp-23604	84	20	critical	critical	ADJ
bjp-23604	84	21	for	for	ADP
bjp-23604	84	22	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	84	23	(	(	PUNCT
bjp-23604	84	24	drusano	drusano	PROPN
bjp-23604	84	25	et	et	PROPN
bjp-23604	84	26	al	al	PROPN
bjp-23604	84	27	.	.	PROPN
bjp-23604	84	28	,	,	PUNCT
bjp-23604	84	29	2004	2004	NUM
bjp-23604	84	30	)	)	PUNCT
bjp-23604	84	31	.	.	PUNCT
bjp-23604	85	1	for	for	ADP
bjp-23604	85	2	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	85	3	,	,	PUNCT
bjp-23604	85	4	at	at	ADP
bjp-23604	85	5	cmax/	cmax/	NUM
bjp-23604	85	6	mic	mic	ADJ
bjp-23604	85	7	ratio	ratio	NOUN
bjp-23604	85	8	>	>	PROPN
bjp-23604	85	9	10	10	NUM
bjp-23604	85	10	(	(	PUNCT
bjp-23604	85	11	drusano	drusano	PROPN
bjp-23604	85	12	et	et	PROPN
bjp-23604	85	13	al	al	PROPN
bjp-23604	85	14	.	.	PROPN
bjp-23604	85	15	,	,	PUNCT
bjp-23604	85	16	2004	2004	NUM
bjp-23604	85	17	)	)	PUNCT
bjp-23604	85	18	,	,	PUNCT
bjp-23604	85	19	this	this	PRON
bjp-23604	85	20	is	be	AUX
bjp-23604	85	21	the	the	DET
bjp-23604	85	22	best	good	ADJ
bjp-23604	85	23	predictor	predictor	NOUN
bjp-23604	85	24	of	of	ADP
bjp-23604	85	25	clinical	clinical	ADJ
bjp-23604	85	26	outcome	outcome	NOUN
bjp-23604	85	27	,	,	PUNCT
bjp-23604	85	28	but	but	CCONJ
bjp-23604	85	29	at	at	ADP
bjp-23604	85	30	lower	low	ADJ
bjp-23604	85	31	peak	peak	NOUN
bjp-23604	85	32	concentrations	concentration	NOUN
bjp-23604	85	33	,	,	PUNCT
bjp-23604	85	34	auc	auc	ADJ
bjp-23604	85	35	/	/	SYM
bjp-23604	85	36	mic	mic	ADJ
bjp-23604	85	37	ratio	ratio	NOUN
bjp-23604	85	38	is	be	AUX
bjp-23604	85	39	of	of	ADP
bjp-23604	85	40	better	well	ADJ
bjp-23604	85	41	predictive	predictive	ADJ
bjp-23604	85	42	value	value	NOUN
bjp-23604	85	43	.	.	PUNCT
bjp-23604	86	1	auc	auc	NOUN
bjp-23604	86	2	/	/	SYM
bjp-23604	86	3	mic	mic	ADJ
bjp-23604	86	4	value	value	NOUN
bjp-23604	86	5	>	>	X
bjp-23604	86	6	25	25	NUM
bjp-23604	86	7	might	might	AUX
bjp-23604	86	8	be	be	AUX
bjp-23604	86	9	sufficient	sufficient	ADJ
bjp-23604	86	10	for	for	ADP
bjp-23604	86	11	less	less	ADV
bjp-23604	86	12	severe	severe	ADJ
bjp-23604	86	13	infections	infection	NOUN
bjp-23604	86	14	and/or	and/or	CCONJ
bjp-23604	86	15	immunocompetent	immunocompetent	ADJ
bjp-23604	86	16	hosts	host	NOUN
bjp-23604	86	17	,	,	PUNCT
bjp-23604	86	18	but	but	CCONJ
bjp-23604	86	19	with	with	ADP
bjp-23604	86	20	a	a	DET
bjp-23604	86	21	value	value	NOUN
bjp-23604	86	22	of	of	ADP
bjp-23604	86	23	>	>	PRON
bjp-23604	86	24	100	100	NUM
bjp-23604	86	25	appear	appear	VERB
bjp-23604	86	26	necessary	necessary	ADJ
bjp-23604	86	27	for	for	ADP
bjp-23604	86	28	severe	severe	ADJ
bjp-23604	86	29	infections	infection	NOUN
bjp-23604	86	30	and/or	and/or	CCONJ
bjp-23604	86	31	immune	immune	NOUN
bjp-23604	86	32	-	-	PUNCT
bjp-23604	86	33	compromised	compromise	VERB
bjp-23604	86	34	hosts	host	NOUN
bjp-23604	86	35	(	(	PUNCT
bjp-23604	86	36	jacobs	jacobs	PROPN
bjp-23604	86	37	,	,	PUNCT
bjp-23604	86	38	2001	2001	NUM
bjp-23604	86	39	)	)	PUNCT
bjp-23604	86	40	.	.	PUNCT
bjp-23604	87	1	however	however	ADV
bjp-23604	87	2	,	,	PUNCT
bjp-23604	87	3	level	level	NOUN
bjp-23604	87	4	of	of	ADP
bjp-23604	87	5	auc	auc	NOUN
bjp-23604	87	6	/	/	SYM
bjp-23604	87	7	mic	mic	NOUN
bjp-23604	87	8	of	of	ADP
bjp-23604	87	9	125	125	NUM
bjp-23604	87	10	established	establish	VERB
bjp-23604	87	11	in	in	ADP
bjp-23604	87	12	the	the	DET
bjp-23604	87	13	study	study	NOUN
bjp-23604	87	14	of	of	ADP
bjp-23604	87	15	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	87	16	of	of	ADP
bjp-23604	87	17	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	87	18	in	in	ADP
bjp-23604	87	19	critically	critically	ADV
bjp-23604	87	20	ill	ill	ADJ
bjp-23604	87	21	has	have	AUX
bjp-23604	87	22	been	be	AUX
bjp-23604	87	23	widely	widely	ADV
bjp-23604	87	24	accepted	accept	VERB
bjp-23604	87	25	as	as	ADP
bjp-23604	87	26	an	an	DET
bjp-23604	87	27	endpoint	endpoint	NOUN
bjp-23604	87	28	that	that	PRON
bjp-23604	87	29	correlates	correlate	VERB
bjp-23604	87	30	best	well	ADV
bjp-23604	87	31	with	with	ADP
bjp-23604	87	32	rapid	rapid	ADJ
bjp-23604	87	33	bacteriologic	bacteriologic	ADJ
bjp-23604	87	34	and	and	CCONJ
bjp-23604	87	35	clinical	clinical	ADJ
bjp-23604	87	36	responses	response	NOUN
bjp-23604	87	37	(	(	PUNCT
bjp-23604	87	38	forest	forest	NOUN
bjp-23604	87	39	et	et	PROPN
bjp-23604	87	40	al	al	PROPN
bjp-23604	87	41	.	.	PROPN
bjp-23604	87	42	,	,	PUNCT
bjp-23604	87	43	2004	2004	NUM
bjp-23604	87	44	)	)	PUNCT
bjp-23604	87	45	.	.	PUNCT
bjp-23604	88	1	in	in	ADP
bjp-23604	88	2	evaluation	evaluation	NOUN
bjp-23604	88	3	of	of	ADP
bjp-23604	88	4	adequacy	adequacy	NOUN
bjp-23604	88	5	of	of	ADP
bjp-23604	88	6	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	88	7	in	in	ADP
bjp-23604	88	8	treatment	treatment	NOUN
bjp-23604	88	9	of	of	ADP
bjp-23604	88	10	complicated	complicated	ADJ
bjp-23604	88	11	urinary	urinary	ADJ
bjp-23604	88	12	tract	tract	NOUN
bjp-23604	88	13	infections	infection	NOUN
bjp-23604	88	14	ciprofloxacin	ciprofloxacin	PRON
bjp-23604	88	15	was	be	AUX
bjp-23604	88	16	tested	test	VERB
bjp-23604	88	17	on	on	ADP
bjp-23604	88	18	4	4	NUM
bjp-23604	88	19	different	different	ADJ
bjp-23604	88	20	bacterial	bacterial	ADJ
bjp-23604	88	21	strains	strain	NOUN
bjp-23604	88	22	from	from	ADP
bjp-23604	88	23	urinary	urinary	ADJ
bjp-23604	88	24	isolates	isolate	NOUN
bjp-23604	88	25	.	.	PUNCT
bjp-23604	89	1	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	89	2	showed	show	VERB
bjp-23604	89	3	excellent	excellent	ADJ
bjp-23604	89	4	effect	effect	NOUN
bjp-23604	89	5	on	on	ADP
bjp-23604	89	6	escherichia	escherichia	NOUN
bjp-23604	89	7	and	and	CCONJ
bjp-23604	89	8	proteus	proteus	NOUN
bjp-23604	89	9	strains	strain	NOUN
bjp-23604	89	10	but	but	CCONJ
bjp-23604	89	11	even	even	ADV
bjp-23604	89	12	though	though	SCONJ
bjp-23604	89	13	all	all	DET
bjp-23604	89	14	strains	strain	NOUN
bjp-23604	89	15	were	be	AUX
bjp-23604	89	16	listed	list	VERB
bjp-23604	89	17	as	as	ADV
bjp-23604	89	18	susceptible	susceptible	ADJ
bjp-23604	89	19	according	accord	VERB
bjp-23604	89	20	to	to	ADP
bjp-23604	89	21	the	the	DET
bjp-23604	89	22	microbiological	microbiological	ADJ
bjp-23604	89	23	standards	standard	NOUN
bjp-23604	89	24	,	,	PUNCT
bjp-23604	89	25	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	89	26	/	/	SYM
bjp-23604	89	27	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	89	28	evaluation	evaluation	NOUN
bjp-23604	89	29	suggested	suggest	VERB
bjp-23604	89	30	that	that	SCONJ
bjp-23604	89	31	plasma	plasma	NOUN
bjp-23604	89	32	concentrations	concentration	NOUN
bjp-23604	89	33	reached	reach	VERB
bjp-23604	89	34	using	use	VERB
bjp-23604	89	35	standard	standard	ADJ
bjp-23604	89	36	dosing	dosing	ADJ
bjp-23604	89	37	regimens	regimen	NOUN
bjp-23604	89	38	(	(	PUNCT
bjp-23604	89	39	500	500	NUM
bjp-23604	89	40	mg/12	mg/12	PROPN
bjp-23604	89	41	hours	hour	NOUN
bjp-23604	89	42	and	and	CCONJ
bjp-23604	89	43	750	750	NUM
bjp-23604	89	44	mg/12	mg/12	PROPN
bjp-23604	89	45	hours	hour	NOUN
bjp-23604	89	46	)	)	PUNCT
bjp-23604	89	47	were	be	AUX
bjp-23604	89	48	not	not	PART
bjp-23604	89	49	adequate	adequate	ADJ
bjp-23604	89	50	to	to	PART
bjp-23604	89	51	successfully	successfully	ADV
bjp-23604	89	52	treat	treat	VERB
bjp-23604	89	53	infections	infection	NOUN
bjp-23604	89	54	caused	cause	VERB
bjp-23604	89	55	by	by	ADP
bjp-23604	89	56	all	all	DET
bjp-23604	89	57	tested	test	VERB
bjp-23604	89	58	pathogens	pathogen	NOUN
bjp-23604	89	59	.	.	PUNCT
bjp-23604	90	1	influence	influence	NOUN
bjp-23604	90	2	of	of	ADP
bjp-23604	90	3	the	the	DET
bjp-23604	90	4	type	type	NOUN
bjp-23604	90	5	of	of	ADP
bjp-23604	90	6	the	the	DET
bjp-23604	90	7	pathogen	pathogen	NOUN
bjp-23604	90	8	causing	cause	VERB
bjp-23604	90	9	the	the	DET
bjp-23604	90	10	infection	infection	NOUN
bjp-23604	90	11	on	on	ADP
bjp-23604	90	12	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	90	13	/	/	SYM
bjp-23604	90	14	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	90	15	breakpoints	breakpoint	NOUN
bjp-23604	90	16	is	be	AUX
bjp-23604	90	17	reflected	reflect	VERB
bjp-23604	90	18	in	in	ADP
bjp-23604	90	19	the	the	DET
bjp-23604	90	20	mic	mic	ADJ
bjp-23604	90	21	value	value	NOUN
bjp-23604	90	22	.	.	PUNCT
bjp-23604	91	1	microorganisms	microorganism	NOUN
bjp-23604	91	2	listed	list	VERB
bjp-23604	91	3	as	as	ADP
bjp-23604	91	4	susceptible	susceptible	ADJ
bjp-23604	91	5	can	can	AUX
bjp-23604	91	6	have	have	VERB
bjp-23604	91	7	wide	wide	ADJ
bjp-23604	91	8	range	range	NOUN
bjp-23604	91	9	of	of	ADP
bjp-23604	91	10	actual	actual	ADJ
bjp-23604	91	11	mic	mic	ADJ
bjp-23604	91	12	values	value	NOUN
bjp-23604	91	13	,	,	PUNCT
bjp-23604	91	14	and	and	CCONJ
bjp-23604	91	15	since	since	SCONJ
bjp-23604	91	16	mic	mic	NOUN
bjp-23604	91	17	are	be	AUX
bjp-23604	91	18	reported	report	VERB
bjp-23604	91	19	in	in	ADP
bjp-23604	91	20	multiplication	multiplication	NOUN
bjp-23604	91	21	factors	factor	NOUN
bjp-23604	91	22	of	of	ADP
bjp-23604	91	23	two	two	NUM
bjp-23604	91	24	,	,	PUNCT
bjp-23604	91	25	with	with	SCONJ
bjp-23604	91	26	each	each	DET
bjp-23604	91	27	level	level	NOUN
bjp-23604	91	28	of	of	ADP
bjp-23604	91	29	decreased	decrease	VERB
bjp-23604	91	30	susceptibility	susceptibility	NOUN
bjp-23604	91	31	a	a	DET
bjp-23604	91	32	two	two	NUM
bjp-23604	91	33	-	-	ADJ
bjp-23604	91	34	fold	fold	ADJ
bjp-23604	91	35	increase	increase	NOUN
bjp-23604	91	36	in	in	ADP
bjp-23604	91	37	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	91	38	component	component	NOUN
bjp-23604	91	39	of	of	ADP
bjp-23604	91	40	pharmacokinetic	pharmacokinetic	NOUN
bjp-23604	91	41	/	/	SYM
bjp-23604	91	42	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	91	43	is	be	AUX
bjp-23604	91	44	necessary	necessary	ADJ
bjp-23604	91	45	to	to	PART
bjp-23604	91	46	maintain	maintain	VERB
bjp-23604	91	47	the	the	DET
bjp-23604	91	48	target	target	NOUN
bjp-23604	91	49	ratio	ratio	NOUN
bjp-23604	91	50	(	(	PUNCT
bjp-23604	91	51	schentag	schentag	ADJ
bjp-23604	91	52	,	,	PUNCT
bjp-23604	91	53	2000	2000	NUM
bjp-23604	91	54	)	)	PUNCT
bjp-23604	91	55	.	.	PUNCT
bjp-23604	92	1	clinical	clinical	ADJ
bjp-23604	92	2	breakpoints	breakpoint	NOUN
bjp-23604	92	3	are	be	AUX
bjp-23604	92	4	used	use	VERB
bjp-23604	92	5	in	in	ADP
bjp-23604	92	6	clinical	clinical	ADJ
bjp-23604	92	7	microbiology	microbiology	NOUN
bjp-23604	92	8	laboratories	laboratory	NOUN
bjp-23604	92	9	to	to	PART
bjp-23604	92	10	categorize	categorize	VERB
bjp-23604	92	11	microorganisms	microorganism	NOUN
bjp-23604	92	12	as	as	ADP
bjp-23604	92	13	clinically	clinically	ADV
bjp-23604	92	14	susceptible	susceptible	ADJ
bjp-23604	92	15	,	,	PUNCT
bjp-23604	92	16	intermediate	intermediate	ADJ
bjp-23604	92	17	or	or	CCONJ
bjp-23604	92	18	resistant	resistant	ADJ
bjp-23604	92	19	depending	depend	VERB
bjp-23604	92	20	on	on	ADP
bjp-23604	92	21	the	the	DET
bjp-23604	92	22	quantitative	quantitative	ADJ
bjp-23604	92	23	antimicrobial	antimicrobial	ADJ
bjp-23604	92	24	susceptibility	susceptibility	NOUN
bjp-23604	92	25	as	as	SCONJ
bjp-23604	92	26	indicated	indicate	VERB
bjp-23604	92	27	by	by	ADP
bjp-23604	92	28	the	the	DET
bjp-23604	92	29	mic	mic	ADJ
bjp-23604	92	30	value	value	NOUN
bjp-23604	92	31	determined	determine	VERB
bjp-23604	92	32	in	in	ADP
bjp-23604	92	33	a	a	DET
bjp-23604	92	34	well	well	ADV
bjp-23604	92	35	-	-	PUNCT
bjp-23604	92	36	defined	define	VERB
bjp-23604	92	37	standard	standard	ADJ
bjp-23604	92	38	test	test	NOUN
bjp-23604	92	39	system	system	NOUN
bjp-23604	92	40	(	(	PUNCT
bjp-23604	92	41	mouton	mouton	PROPN
bjp-23604	92	42	et	et	PROPN
bjp-23604	92	43	al	al	PROPN
bjp-23604	92	44	.	.	PROPN
bjp-23604	92	45	,2012	,2012	PUNCT
bjp-23604	92	46	)	)	PUNCT
bjp-23604	92	47	.	.	PUNCT
bjp-23604	93	1	however	however	ADV
bjp-23604	93	2	,	,	PUNCT
bjp-23604	93	3	whether	whether	SCONJ
bjp-23604	93	4	the	the	DET
bjp-23604	93	5	results	result	NOUN
bjp-23604	93	6	of	of	ADP
bjp-23604	93	7	the	the	DET
bjp-23604	93	8	in	in	ADV
bjp-23604	93	9	vitro	vitro	X
bjp-23604	93	10	624	624	NUM
bjp-23604	93	11	bangladesh	bangladesh	NOUN
bjp-23604	93	12	j	j	PROPN
bjp-23604	93	13	pharmacol	pharmacol	PROPN
bjp-23604	93	14	2015	2015	NUM
bjp-23604	93	15	;	;	PUNCT
bjp-23604	93	16	10	10	NUM
bjp-23604	93	17	:	:	SYM
bjp-23604	93	18	621	621	NUM
bjp-23604	93	19	-	-	SYM
bjp-23604	93	20	626	626	NUM
bjp-23604	93	21	table	table	NOUN
bjp-23604	93	22	ii	ii	NOUN
bjp-23604	93	23	pharmacokinetic	pharmacokinetic	NOUN
bjp-23604	93	24	/	/	SYM
bjp-23604	93	25	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	93	26	efficacy	efficacy	NOUN
bjp-23604	93	27	indices	index	NOUN
bjp-23604	93	28	and	and	CCONJ
bjp-23604	93	29	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	93	30	/	/	SYM
bjp-23604	93	31	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	93	32	breakpoints	breakpoint	NOUN
bjp-23604	93	33	following	follow	VERB
bjp-23604	93	34	orally	orally	ADV
bjp-23604	93	35	administered	administer	VERB
bjp-23604	93	36	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	93	37	pk	pk	PROPN
bjp-23604	93	38	/	/	SYM
bjp-23604	93	39	pd	pd	PROPN
bjp-23604	93	40	index	index	NOUN
bjp-23604	93	41	escherichia	escherichia	NOUN
bjp-23604	93	42	coli	coli	NOUN
bjp-23604	93	43	,	,	PUNCT
bjp-23604	93	44	proteus	proteus	NOUN
bjp-23604	93	45	mirabilis	mirabilis	PROPN
bjp-23604	93	46	(	(	PUNCT
bjp-23604	93	47	mic	mic	ADJ
bjp-23604	93	48	0.0156	0.0156	NUM
bjp-23604	93	49	)	)	PUNCT
bjp-23604	93	50	staphylococcus	staphylococcus	NOUN
bjp-23604	93	51	epidermidis	epidermidi	NOUN
bjp-23604	93	52	(	(	PUNCT
bjp-23604	93	53	mic	mic	ADJ
bjp-23604	93	54	0.5	0.5	NUM
bjp-23604	93	55	)	)	PUNCT
bjp-23604	93	56	staphylococcus	staphylococcus	NOUN
bjp-23604	93	57	aureus	aureus	NOUN
bjp-23604	93	58	(	(	PUNCT
bjp-23604	93	59	mic	mic	NOUN
bjp-23604	93	60	0.125	0.125	NUM
bjp-23604	93	61	)	)	PUNCT
bjp-23604	93	62	pk	pk	PROPN
bjp-23604	93	63	/	/	SYM
bjp-23604	93	64	pd	pd	PROPN
bjp-23604	93	65	breakpoint	breakpoint	NOUN
bjp-23604	93	66	auc	auc	NOUN
bjp-23604	93	67	/	/	SYM
bjp-23604	93	68	mic	mic	ADJ
bjp-23604	93	69	auc	auc	NOUN
bjp-23604	93	70	/	/	SYM
bjp-23604	93	71	mic	mic	ADJ
bjp-23604	93	72	auc	auc	NOUN
bjp-23604	93	73	/	/	SYM
bjp-23604	93	74	mic	mic	ADJ
bjp-23604	93	75	target	target	NOUN
bjp-23604	93	76	auc	auc	NOUN
bjp-23604	93	77	/	/	SYM
bjp-23604	93	78	mic	mic	NOUN
bjp-23604	93	79	>	>	X
bjp-23604	93	80	125	125	NUM
bjp-23604	93	81	500	500	NUM
bjp-23604	93	82	mg	mg	NUM
bjp-23604	93	83	12	12	NUM
bjp-23604	93	84	hourly	hourly	ADV
bjp-23604	93	85	859.0	859.0	NUM
bjp-23604	93	86	26.8	26.8	NUM
bjp-23604	93	87	107.2	107.2	NUM
bjp-23604	93	88	0.1	0.1	NUM
bjp-23604	93	89	µg	µg	NOUN
bjp-23604	93	90	/	/	SYM
bjp-23604	93	91	ml	ml	NOUN
bjp-23604	93	92	750	750	NUM
bjp-23604	93	93	mg	mg	NUM
bjp-23604	93	94	12	12	NUM
bjp-23604	93	95	hourly	hourly	ADJ
bjp-23604	93	96	1718.2	1718.2	NUM
bjp-23604	93	97	53.6	53.6	NUM
bjp-23604	93	98	214.4	214.4	NUM
bjp-23604	93	99	0.2	0.2	NUM
bjp-23604	93	100	µg	µg	ADJ
bjp-23604	93	101	/	/	SYM
bjp-23604	93	102	ml	ml	VERB
bjp-23604	93	103	cmax	cmax	NOUN
bjp-23604	93	104	/	/	SYM
bjp-23604	93	105	mic	mic	ADJ
bjp-23604	93	106	cmax	cmax	NOUN
bjp-23604	93	107	/	/	SYM
bjp-23604	93	108	mic	mic	ADJ
bjp-23604	93	109	cmax	cmax	NOUN
bjp-23604	93	110	/	/	SYM
bjp-23604	93	111	mic	mic	ADJ
bjp-23604	93	112	target	target	NOUN
bjp-23604	93	113	cmax	cmax	NOUN
bjp-23604	93	114	/	/	SYM
bjp-23604	93	115	mic	mic	NOUN
bjp-23604	93	116	>	>	PROPN
bjp-23604	93	117	10	10	NUM
bjp-23604	93	118	500	500	NUM
bjp-23604	93	119	mg	mg	NUM
bjp-23604	93	120	12	12	NUM
bjp-23604	93	121	hourly	hourly	ADJ
bjp-23604	93	122	78.2	78.2	NUM
bjp-23604	94	1	2.4	2.4	NUM
bjp-23604	94	2	9.8	9.8	NUM
bjp-23604	94	3	0.1	0.1	NUM
bjp-23604	94	4	µg	µg	NOUN
bjp-23604	94	5	/	/	SYM
bjp-23604	94	6	ml	ml	NOUN
bjp-23604	94	7	750	750	NUM
bjp-23604	94	8	mg	mg	NUM
bjp-23604	94	9	12	12	NUM
bjp-23604	94	10	hourly	hourly	ADV
bjp-23604	94	11	154.5	154.5	NUM
bjp-23604	94	12	4.8	4.8	NUM
bjp-23604	94	13	19.3	19.3	NUM
bjp-23604	94	14	0.2	0.2	NUM
bjp-23604	94	15	µg	µg	ADJ
bjp-23604	94	16	/	/	SYM
bjp-23604	94	17	ml	ml	NOUN
bjp-23604	94	18	susceptibility	susceptibility	NOUN
bjp-23604	94	19	testing	testing	NOUN
bjp-23604	94	20	of	of	ADP
bjp-23604	94	21	bacterial	bacterial	ADJ
bjp-23604	94	22	isolates	isolate	NOUN
bjp-23604	94	23	to	to	ADP
bjp-23604	94	24	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	94	25	can	can	AUX
bjp-23604	94	26	predict	predict	VERB
bjp-23604	94	27	the	the	DET
bjp-23604	94	28	clinical	clinical	ADJ
bjp-23604	94	29	outcome	outcome	NOUN
bjp-23604	94	30	of	of	ADP
bjp-23604	94	31	patients	patient	NOUN
bjp-23604	94	32	with	with	ADP
bjp-23604	94	33	urinary	urinary	ADJ
bjp-23604	94	34	tract	tract	NOUN
bjp-23604	94	35	infections	infection	NOUN
bjp-23604	94	36	,	,	PUNCT
bjp-23604	94	37	especially	especially	ADV
bjp-23604	94	38	complicated	complicated	ADJ
bjp-23604	94	39	urinary	urinary	ADJ
bjp-23604	94	40	tract	tract	NOUN
bjp-23604	94	41	infections	infection	NOUN
bjp-23604	94	42	,	,	PUNCT
bjp-23604	94	43	is	be	AUX
bjp-23604	94	44	controversial	controversial	ADJ
bjp-23604	94	45	(	(	PUNCT
bjp-23604	94	46	chen	chen	PROPN
bjp-23604	94	47	et	et	PROPN
bjp-23604	94	48	al	al	PROPN
bjp-23604	94	49	.	.	PROPN
bjp-23604	94	50	,	,	PUNCT
bjp-23604	94	51	2013	2013	NUM
bjp-23604	94	52	)	)	PUNCT
bjp-23604	94	53	.	.	PUNCT
bjp-23604	95	1	clinicians	clinician	NOUN
bjp-23604	95	2	rely	rely	VERB
bjp-23604	95	3	on	on	ADP
bjp-23604	95	4	laboratory	laboratory	NOUN
bjp-23604	95	5	reports	report	NOUN
bjp-23604	95	6	of	of	ADP
bjp-23604	95	7	susceptibility	susceptibility	NOUN
bjp-23604	95	8	of	of	ADP
bjp-23604	95	9	microorganism	microorganism	NOUN
bjp-23604	95	10	to	to	ADP
bjp-23604	95	11	an	an	DET
bjp-23604	95	12	antibiotic	antibiotic	NOUN
bjp-23604	95	13	when	when	SCONJ
bjp-23604	95	14	determining	determine	VERB
bjp-23604	95	15	the	the	DET
bjp-23604	95	16	potential	potential	ADJ
bjp-23604	95	17	use	use	NOUN
bjp-23604	95	18	of	of	ADP
bjp-23604	95	19	an	an	DET
bjp-23604	95	20	antibiotic	antibiotic	NOUN
bjp-23604	95	21	in	in	ADP
bjp-23604	95	22	treatment	treatment	NOUN
bjp-23604	95	23	of	of	ADP
bjp-23604	95	24	infection	infection	NOUN
bjp-23604	95	25	.	.	PUNCT
bjp-23604	96	1	susceptibility	susceptibility	NOUN
bjp-23604	96	2	breakpoint	breakpoint	NOUN
bjp-23604	96	3	of	of	ADP
bjp-23604	96	4	1	1	NUM
bjp-23604	96	5	µg	µg	ADV
bjp-23604	96	6	/	/	SYM
bjp-23604	96	7	ml	ml	X
bjp-23604	96	8	for	for	ADP
bjp-23604	96	9	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	96	10	may	may	AUX
bjp-23604	96	11	categorize	categorize	VERB
bjp-23604	96	12	significant	significant	ADJ
bjp-23604	96	13	numbers	number	NOUN
bjp-23604	96	14	of	of	ADP
bjp-23604	96	15	isolates	isolate	NOUN
bjp-23604	96	16	as	as	ADV
bjp-23604	96	17	susceptible	susceptible	ADJ
bjp-23604	96	18	when	when	SCONJ
bjp-23604	96	19	evidence	evidence	NOUN
bjp-23604	96	20	suggests	suggest	VERB
bjp-23604	96	21	that	that	SCONJ
bjp-23604	96	22	not	not	PART
bjp-23604	96	23	all	all	PRON
bjp-23604	96	24	complicated	complicated	ADJ
bjp-23604	96	25	urinary	urinary	ADJ
bjp-23604	96	26	tract	tract	NOUN
bjp-23604	96	27	infections	infection	NOUN
bjp-23604	96	28	caused	cause	VERB
bjp-23604	96	29	by	by	ADP
bjp-23604	96	30	these	these	DET
bjp-23604	96	31	isolates	isolate	NOUN
bjp-23604	96	32	can	can	AUX
bjp-23604	96	33	be	be	AUX
bjp-23604	96	34	successfully	successfully	ADV
bjp-23604	96	35	treated	treat	VERB
bjp-23604	96	36	with	with	ADP
bjp-23604	96	37	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	96	38	.	.	PUNCT
bjp-23604	97	1	for	for	ADP
bjp-23604	97	2	an	an	DET
bjp-23604	97	3	example	example	NOUN
bjp-23604	97	4	,	,	PUNCT
bjp-23604	97	5	with	with	SCONJ
bjp-23604	97	6	the	the	DET
bjp-23604	97	7	mic	mic	ADJ
bjp-23604	97	8	0.5	0.5	NUM
bjp-23604	97	9	µg	µg	NOUN
bjp-23604	97	10	/	/	SYM
bjp-23604	97	11	ml	ml	ADP
bjp-23604	97	12	this	this	DET
bjp-23604	97	13	strain	strain	NOUN
bjp-23604	97	14	of	of	ADP
bjp-23604	97	15	s.	s.	PROPN
bjp-23604	97	16	epidermidis	epidermidis	PROPN
bjp-23604	97	17	is	be	AUX
bjp-23604	97	18	susceptible	susceptible	ADJ
bjp-23604	97	19	to	to	ADP
bjp-23604	97	20	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	97	21	but	but	CCONJ
bjp-23604	97	22	auc/	auc/	PROPN
bjp-23604	97	23	mic	mic	ADJ
bjp-23604	97	24	ratios	ratio	NOUN
bjp-23604	97	25	are	be	AUX
bjp-23604	97	26	much	much	ADV
bjp-23604	97	27	lower	low	ADJ
bjp-23604	97	28	than	than	ADP
bjp-23604	97	29	the	the	DET
bjp-23604	97	30	desired	desire	VERB
bjp-23604	97	31	threshold	threshold	NOUN
bjp-23604	97	32	of	of	ADP
bjp-23604	97	33	125	125	NUM
bjp-23604	97	34	even	even	ADV
bjp-23604	97	35	for	for	ADP
bjp-23604	97	36	maximum	maximum	ADJ
bjp-23604	97	37	dose	dose	NOUN
bjp-23604	97	38	of	of	ADP
bjp-23604	97	39	750	750	NUM
bjp-23604	97	40	mg	mg	NOUN
bjp-23604	97	41	.	.	PUNCT
bjp-23604	98	1	these	these	DET
bjp-23604	98	2	findings	finding	NOUN
bjp-23604	98	3	indicate	indicate	VERB
bjp-23604	98	4	the	the	DET
bjp-23604	98	5	necessity	necessity	NOUN
bjp-23604	98	6	of	of	ADP
bjp-23604	98	7	reevaluating	reevaluate	VERB
bjp-23604	98	8	current	current	ADJ
bjp-23604	98	9	breakpoints	breakpoint	NOUN
bjp-23604	98	10	used	use	VERB
bjp-23604	98	11	for	for	ADP
bjp-23604	98	12	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	98	13	in	in	ADP
bjp-23604	98	14	our	our	PRON
bjp-23604	98	15	standard	standard	ADJ
bjp-23604	98	16	testing	testing	NOUN
bjp-23604	98	17	.	.	PUNCT
bjp-23604	99	1	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	99	2	/	/	SYM
bjp-23604	99	3	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	99	4	breakpoints	breakpoint	NOUN
bjp-23604	99	5	,	,	PUNCT
bjp-23604	99	6	which	which	PRON
bjp-23604	99	7	illustrate	illustrate	VERB
bjp-23604	99	8	the	the	DET
bjp-23604	99	9	mic	mic	ADJ
bjp-23604	99	10	values	value	NOUN
bjp-23604	99	11	for	for	ADP
bjp-23604	99	12	which	which	PRON
bjp-23604	99	13	main	main	ADJ
bjp-23604	99	14	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	99	15	/	/	SYM
bjp-23604	99	16	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	99	17	ratios	ratio	NOUN
bjp-23604	99	18	reach	reach	VERB
bjp-23604	99	19	values	value	NOUN
bjp-23604	99	20	required	require	VERB
bjp-23604	99	21	for	for	ADP
bjp-23604	99	22	clinical	clinical	ADJ
bjp-23604	99	23	success	success	NOUN
bjp-23604	99	24	(	(	PUNCT
bjp-23604	99	25	jacobs	jacobs	PROPN
bjp-23604	99	26	,	,	PUNCT
bjp-23604	99	27	2001	2001	NUM
bjp-23604	99	28	)	)	PUNCT
bjp-23604	99	29	indicate	indicate	VERB
bjp-23604	99	30	for	for	ADP
bjp-23604	99	31	mic	mic	ADJ
bjp-23604	99	32	over	over	ADP
bjp-23604	99	33	0.2	0.2	NUM
bjp-23604	99	34	µg	µg	ADV
bjp-23604	99	35	/	/	SYM
bjp-23604	99	36	ml	ml	X
bjp-23604	99	37	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	99	38	,	,	PUNCT
bjp-23604	99	39	may	may	AUX
bjp-23604	99	40	not	not	PART
bjp-23604	99	41	provide	provide	VERB
bjp-23604	99	42	eradication	eradication	NOUN
bjp-23604	99	43	of	of	ADP
bjp-23604	99	44	susceptible	susceptible	ADJ
bjp-23604	99	45	organisms	organism	NOUN
bjp-23604	99	46	.	.	PUNCT
bjp-23604	100	1	also	also	ADV
bjp-23604	100	2	,	,	PUNCT
bjp-23604	100	3	an	an	DET
bjp-23604	100	4	interesting	interesting	ADJ
bjp-23604	100	5	insight	insight	NOUN
bjp-23604	100	6	into	into	ADP
bjp-23604	100	7	complexity	complexity	NOUN
bjp-23604	100	8	of	of	ADP
bjp-23604	100	9	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	100	10	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	100	11	has	have	AUX
bjp-23604	100	12	been	be	AUX
bjp-23604	100	13	provided	provide	VERB
bjp-23604	100	14	by	by	ADP
bjp-23604	100	15	the	the	DET
bjp-23604	100	16	presence	presence	NOUN
bjp-23604	100	17	of	of	ADP
bjp-23604	100	18	time	time	NOUN
bjp-23604	100	19	dependent	dependent	ADJ
bjp-23604	100	20	postantibiotic	postantibiotic	ADJ
bjp-23604	100	21	effect	effect	NOUN
bjp-23604	100	22	noted	note	VERB
bjp-23604	100	23	in	in	ADP
bjp-23604	100	24	this	this	DET
bjp-23604	100	25	study	study	NOUN
bjp-23604	100	26	.	.	PUNCT
bjp-23604	101	1	duration	duration	NOUN
bjp-23604	101	2	of	of	ADP
bjp-23604	101	3	postantibiotic	postantibiotic	ADJ
bjp-23604	101	4	effect	effect	NOUN
bjp-23604	101	5	observed	observe	VERB
bjp-23604	101	6	in	in	ADP
bjp-23604	101	7	our	our	PRON
bjp-23604	101	8	study	study	NOUN
bjp-23604	101	9	is	be	AUX
bjp-23604	101	10	in	in	ADP
bjp-23604	101	11	accordance	accordance	NOUN
bjp-23604	101	12	with	with	ADP
bjp-23604	101	13	previous	previous	ADJ
bjp-23604	101	14	research	research	NOUN
bjp-23604	101	15	where	where	SCONJ
bjp-23604	101	16	duration	duration	NOUN
bjp-23604	101	17	of	of	ADP
bjp-23604	101	18	postantibiotic	postantibiotic	ADJ
bjp-23604	101	19	effect	effect	NOUN
bjp-23604	101	20	induced	induce	VERB
bjp-23604	101	21	by	by	ADP
bjp-23604	101	22	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	101	23	on	on	ADP
bjp-23604	101	24	gram	gram	NOUN
bjp-23604	101	25	negative	negative	ADJ
bjp-23604	101	26	bacteria	bacteria	NOUN
bjp-23604	101	27	was	be	AUX
bjp-23604	101	28	1	1	NUM
bjp-23604	101	29	-	-	SYM
bjp-23604	101	30	2.2	2.2	NUM
bjp-23604	101	31	hours	hour	NOUN
bjp-23604	101	32	(	(	PUNCT
bjp-23604	101	33	minguez	minguez	NOUN
bjp-23604	101	34	et	et	PROPN
bjp-23604	101	35	al	al	PROPN
bjp-23604	101	36	.	.	PROPN
bjp-23604	101	37	,	,	PUNCT
bjp-23604	101	38	1991	1991	NUM
bjp-23604	101	39	)	)	PUNCT
bjp-23604	101	40	and	and	CCONJ
bjp-23604	101	41	1.1	1.1	NUM
bjp-23604	101	42	-	-	SYM
bjp-23604	101	43	2.4	2.4	NUM
bjp-23604	101	44	hours	hour	NOUN
bjp-23604	101	45	on	on	ADP
bjp-23604	101	46	gram	gram	NOUN
bjp-23604	101	47	positive	positive	ADJ
bjp-23604	101	48	(	(	PUNCT
bjp-23604	101	49	licata	licata	PROPN
bjp-23604	101	50	et	et	PROPN
bjp-23604	101	51	al	al	PROPN
bjp-23604	101	52	.	.	PROPN
bjp-23604	101	53	,	,	PUNCT
bjp-23604	101	54	1997	1997	NUM
bjp-23604	101	55	)	)	PUNCT
bjp-23604	101	56	.	.	PUNCT
bjp-23604	102	1	while	while	SCONJ
bjp-23604	102	2	,	,	PUNCT
bjp-23604	102	3	as	as	SCONJ
bjp-23604	102	4	expected	expect	VERB
bjp-23604	102	5	,	,	PUNCT
bjp-23604	102	6	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	102	7	exhibited	exhibit	VERB
bjp-23604	102	8	strong	strong	ADJ
bjp-23604	102	9	concentration	concentration	NOUN
bjp-23604	102	10	-	-	PUNCT
bjp-23604	102	11	dependent	dependent	ADJ
bjp-23604	102	12	postantibiotic	postantibiotic	ADJ
bjp-23604	102	13	effect	effect	NOUN
bjp-23604	102	14	,	,	PUNCT
bjp-23604	102	15	time	time	NOUN
bjp-23604	102	16	-	-	PUNCT
bjp-23604	102	17	dependent	dependent	ADJ
bjp-23604	102	18	postantibiotic	postantibiotic	ADJ
bjp-23604	102	19	effect	effect	NOUN
bjp-23604	102	20	was	be	AUX
bjp-23604	102	21	also	also	ADV
bjp-23604	102	22	detected	detect	VERB
bjp-23604	102	23	.	.	PUNCT
bjp-23604	103	1	at	at	ADP
bjp-23604	103	2	the	the	DET
bjp-23604	103	3	same	same	ADJ
bjp-23604	103	4	antibiotic	antibiotic	ADJ
bjp-23604	103	5	concentrations	concentration	NOUN
bjp-23604	103	6	postantibiotic	postantibiotic	ADJ
bjp-23604	103	7	effect	effect	NOUN
bjp-23604	103	8	duration	duration	NOUN
bjp-23604	103	9	increased	increase	VERB
bjp-23604	103	10	with	with	ADP
bjp-23604	103	11	prolonged	prolonged	ADJ
bjp-23604	103	12	exposure	exposure	NOUN
bjp-23604	103	13	to	to	ADP
bjp-23604	103	14	antibiotic	antibiotic	ADJ
bjp-23604	103	15	.	.	PUNCT
bjp-23604	104	1	for	for	ADP
bjp-23604	104	2	instance	instance	NOUN
bjp-23604	104	3	,	,	PUNCT
bjp-23604	104	4	at	at	ADP
bjp-23604	104	5	concentration	concentration	NOUN
bjp-23604	104	6	of	of	ADP
bjp-23604	104	7	4	4	NUM
bjp-23604	104	8	times	time	NOUN
bjp-23604	104	9	the	the	DET
bjp-23604	104	10	mic	mic	NOUN
bjp-23604	104	11	for	for	ADP
bjp-23604	104	12	proteus	proteus	NOUN
bjp-23604	104	13	mirabilis	mirabilis	PROPN
bjp-23604	104	14	after	after	ADP
bjp-23604	104	15	incubation	incubation	NOUN
bjp-23604	104	16	for	for	ADP
bjp-23604	104	17	1	1	NUM
bjp-23604	104	18	and	and	CCONJ
bjp-23604	104	19	2	2	NUM
bjp-23604	104	20	hours	hour	NOUN
bjp-23604	104	21	,	,	PUNCT
bjp-23604	104	22	postantibiotic	postantibiotic	ADJ
bjp-23604	104	23	effect	effect	NOUN
bjp-23604	104	24	has	have	AUX
bjp-23604	104	25	increased	increase	VERB
bjp-23604	104	26	from	from	ADP
bjp-23604	104	27	1.23	1.23	NUM
bjp-23604	104	28	to	to	ADP
bjp-23604	104	29	2.13	2.13	NUM
bjp-23604	104	30	hours	hour	NOUN
bjp-23604	104	31	prospectively	prospectively	ADV
bjp-23604	104	32	.	.	PUNCT
bjp-23604	105	1	same	same	ADJ
bjp-23604	105	2	was	be	AUX
bjp-23604	105	3	observed	observe	VERB
bjp-23604	105	4	for	for	ADP
bjp-23604	105	5	all	all	DET
bjp-23604	105	6	4	4	NUM
bjp-23604	105	7	bacterial	bacterial	ADJ
bjp-23604	105	8	strains	strain	NOUN
bjp-23604	105	9	,	,	PUNCT
bjp-23604	105	10	bur	bur	NOUN
bjp-23604	105	11	timedependent	timedependent	NOUN
bjp-23604	105	12	postantibiotic	postantibiotic	ADJ
bjp-23604	105	13	effect	effect	NOUN
bjp-23604	105	14	was	be	AUX
bjp-23604	105	15	the	the	DET
bjp-23604	105	16	most	most	ADV
bjp-23604	105	17	prominent	prominent	ADJ
bjp-23604	105	18	at	at	ADP
bjp-23604	105	19	higher	high	ADJ
bjp-23604	105	20	concentrations	concentration	NOUN
bjp-23604	105	21	.	.	PUNCT
bjp-23604	106	1	this	this	PRON
bjp-23604	106	2	shows	show	VERB
bjp-23604	106	3	that	that	SCONJ
bjp-23604	106	4	that	that	SCONJ
bjp-23604	106	5	not	not	PART
bjp-23604	106	6	only	only	ADV
bjp-23604	106	7	concentration	concentration	NOUN
bjp-23604	106	8	of	of	ADP
bjp-23604	106	9	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	106	10	plays	play	VERB
bjp-23604	106	11	an	an	DET
bjp-23604	106	12	important	important	ADJ
bjp-23604	106	13	role	role	NOUN
bjp-23604	106	14	in	in	ADP
bjp-23604	106	15	bacterial	bacterial	ADJ
bjp-23604	106	16	killing	killing	NOUN
bjp-23604	106	17	but	but	CCONJ
bjp-23604	106	18	that	that	DET
bjp-23604	106	19	time	time	NOUN
bjp-23604	106	20	of	of	ADP
bjp-23604	106	21	exposure	exposure	NOUN
bjp-23604	106	22	to	to	ADP
bjp-23604	106	23	antibiotic	antibiotic	NOUN
bjp-23604	106	24	is	be	AUX
bjp-23604	106	25	also	also	ADV
bjp-23604	106	26	significant	significant	ADJ
bjp-23604	106	27	.	.	PUNCT
bjp-23604	107	1	this	this	PRON
bjp-23604	107	2	was	be	AUX
bjp-23604	107	3	also	also	ADV
bjp-23604	107	4	demonstrated	demonstrate	VERB
bjp-23604	107	5	in	in	ADP
bjp-23604	107	6	a	a	DET
bjp-23604	107	7	study	study	NOUN
bjp-23604	107	8	by	by	ADP
bjp-23604	107	9	zelenitsky	zelenitsky	PROPN
bjp-23604	107	10	et	et	PROPN
bjp-23604	107	11	al	al	PROPN
bjp-23604	107	12	.	.	PROPN
bjp-23604	107	13	showed	show	VERB
bjp-23604	107	14	that	that	SCONJ
bjp-23604	107	15	the	the	DET
bjp-23604	107	16	auc/	auc/	PROPN
bjp-23604	107	17	mic	mic	NOUN
bjp-23604	107	18	was	be	AUX
bjp-23604	107	19	most	most	ADV
bjp-23604	107	20	strongly	strongly	ADV
bjp-23604	107	21	associated	associate	VERB
bjp-23604	107	22	with	with	ADP
bjp-23604	107	23	bactericidal	bactericidal	ADJ
bjp-23604	107	24	activity	activity	NOUN
bjp-23604	107	25	and	and	CCONJ
bjp-23604	107	26	the	the	DET
bjp-23604	107	27	cmax	cmax	NOUN
bjp-23604	107	28	/	/	SYM
bjp-23604	107	29	mic	mic	NOUN
bjp-23604	107	30	was	be	AUX
bjp-23604	107	31	most	most	ADV
bjp-23604	107	32	predictive	predictive	ADJ
bjp-23604	107	33	of	of	ADP
bjp-23604	107	34	early	early	ADJ
bjp-23604	107	35	bacterial	bacterial	ADJ
bjp-23604	107	36	killing	killing	NOUN
bjp-23604	107	37	the	the	DET
bjp-23604	107	38	time	time	NOUN
bjp-23604	107	39	at	at	ADP
bjp-23604	107	40	which	which	PRON
bjp-23604	107	41	levels	level	NOUN
bjp-23604	107	42	of	of	ADP
bjp-23604	107	43	drug	drug	NOUN
bjp-23604	107	44	exceed	exceed	VERB
bjp-23604	107	45	the	the	DET
bjp-23604	107	46	mic	mic	NOUN
bjp-23604	107	47	(	(	PUNCT
bjp-23604	107	48	t	t	NOUN
bjp-23604	107	49	>	>	X
bjp-23604	107	50	mic	mic	NOUN
bjp-23604	107	51	)	)	PUNCT
bjp-23604	107	52	was	be	AUX
bjp-23604	107	53	significantly	significantly	ADV
bjp-23604	107	54	associated	associate	VERB
bjp-23604	107	55	with	with	ADP
bjp-23604	107	56	the	the	DET
bjp-23604	107	57	final	final	ADJ
bjp-23604	107	58	bacterial	bacterial	ADJ
bjp-23604	107	59	counts	count	NOUN
bjp-23604	107	60	at	at	ADP
bjp-23604	107	61	24	24	NUM
bjp-23604	107	62	hours	hour	NOUN
bjp-23604	107	63	(	(	PUNCT
bjp-23604	107	64	zelenitsky	zelenitsky	PROPN
bjp-23604	107	65	et	et	PROPN
bjp-23604	107	66	al	al	PROPN
bjp-23604	107	67	.	.	PROPN
bjp-23604	107	68	,	,	PUNCT
bjp-23604	107	69	2003	2003	NUM
bjp-23604	107	70	)	)	PUNCT
bjp-23604	107	71	.	.	PUNCT
bjp-23604	108	1	for	for	ADP
bjp-23604	108	2	example	example	NOUN
bjp-23604	108	3	,	,	PUNCT
bjp-23604	108	4	a	a	DET
bjp-23604	108	5	t	t	NOUN
bjp-23604	108	6	>	>	PUNCT
bjp-23604	108	7	mic	mic	ADJ
bjp-23604	108	8	value	value	NOUN
bjp-23604	108	9	of	of	ADP
bjp-23604	108	10	<	<	X
bjp-23604	108	11	55	55	NUM
bjp-23604	108	12	%	%	NOUN
bjp-23604	108	13	of	of	ADP
bjp-23604	108	14	the	the	DET
bjp-23604	108	15	dosing	dosing	NOUN
bjp-23604	108	16	interval	interval	NOUN
bjp-23604	108	17	was	be	AUX
bjp-23604	108	18	only	only	ADV
bjp-23604	108	19	bacteriostatic	bacteriostatic	ADJ
bjp-23604	108	20	and	and	CCONJ
bjp-23604	108	21	maximal	maximal	ADJ
bjp-23604	108	22	antibacterial	antibacterial	ADJ
bjp-23604	108	23	response	response	NOUN
bjp-23604	108	24	at	at	ADP
bjp-23604	108	25	24	24	NUM
bjp-23604	108	26	hours	hour	NOUN
bjp-23604	108	27	was	be	AUX
bjp-23604	108	28	associated	associate	VERB
bjp-23604	108	29	with	with	ADP
bjp-23604	108	30	t	t	PROPN
bjp-23604	108	31	>	>	SYM
bjp-23604	108	32	mics	mics	PROPN
bjp-23604	108	33	>	>	X
bjp-23604	108	34	70	70	NUM
bjp-23604	108	35	%	%	NOUN
bjp-23604	108	36	.	.	PUNCT
bjp-23604	109	1	importance	importance	NOUN
bjp-23604	109	2	of	of	ADP
bjp-23604	109	3	adequate	adequate	ADJ
bjp-23604	109	4	dosing	dosing	ADJ
bjp-23604	109	5	intervals	interval	NOUN
bjp-23604	109	6	lies	lie	VERB
bjp-23604	109	7	in	in	ADP
bjp-23604	109	8	the	the	DET
bjp-23604	109	9	fact	fact	NOUN
bjp-23604	109	10	that	that	SCONJ
bjp-23604	109	11	the	the	DET
bjp-23604	109	12	same	same	ADJ
bjp-23604	109	13	auc	auc	NOUN
bjp-23604	109	14	/	/	SYM
bjp-23604	109	15	mic	mic	ADJ
bjp-23604	109	16	ratio	ratio	NOUN
bjp-23604	109	17	can	can	AUX
bjp-23604	109	18	be	be	AUX
bjp-23604	109	19	obtained	obtain	VERB
bjp-23604	109	20	with	with	ADP
bjp-23604	109	21	different	different	ADJ
bjp-23604	109	22	dosing	dosing	NOUN
bjp-23604	109	23	regimens	regimen	NOUN
bjp-23604	109	24	but	but	CCONJ
bjp-23604	109	25	can	can	AUX
bjp-23604	109	26	result	result	VERB
bjp-23604	109	27	in	in	ADP
bjp-23604	109	28	different	different	ADJ
bjp-23604	109	29	cmax	cmax	NOUN
bjp-23604	109	30	/	/	SYM
bjp-23604	109	31	mic	mic	NOUN
bjp-23604	109	32	or	or	CCONJ
bjp-23604	109	33	t	t	NOUN
bjp-23604	109	34	>	>	SYM
bjp-23604	109	35	mic	mic	ADJ
bjp-23604	109	36	parameters	parameter	NOUN
bjp-23604	109	37	(	(	PUNCT
bjp-23604	109	38	scaglione	scaglione	NOUN
bjp-23604	109	39	et	et	PROPN
bjp-23604	109	40	al	al	PROPN
bjp-23604	109	41	.	.	PROPN
bjp-23604	109	42	,	,	PUNCT
bjp-23604	109	43	2003	2003	NUM
bjp-23604	109	44	)	)	PUNCT
bjp-23604	109	45	.	.	PUNCT
bjp-23604	110	1	other	other	ADJ
bjp-23604	110	2	important	important	ADJ
bjp-23604	110	3	application	application	NOUN
bjp-23604	110	4	of	of	ADP
bjp-23604	110	5	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	110	6	/	/	SYM
bjp-23604	110	7	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	110	8	breakpoints	breakpoint	NOUN
bjp-23604	110	9	in	in	ADP
bjp-23604	110	10	choosing	choose	VERB
bjp-23604	110	11	the	the	DET
bjp-23604	110	12	dosing	dose	VERB
bjp-23604	110	13	regimen	regimen	NOUN
bjp-23604	110	14	lies	lie	VERB
bjp-23604	110	15	in	in	ADP
bjp-23604	110	16	the	the	DET
bjp-23604	110	17	fact	fact	NOUN
bjp-23604	110	18	that	that	SCONJ
bjp-23604	110	19	maximizing	maximize	VERB
bjp-23604	110	20	the	the	DET
bjp-23604	110	21	t	t	PROPN
bjp-23604	110	22	>	>	X
bjp-23604	110	23	mic	mic	ADJ
bjp-23604	110	24	and	and	CCONJ
bjp-23604	110	25	auc	auc	ADJ
bjp-23604	110	26	/	/	SYM
bjp-23604	110	27	mic	mic	NOUN
bjp-23604	110	28	may	may	AUX
bjp-23604	110	29	offer	offer	VERB
bjp-23604	110	30	an	an	DET
bjp-23604	110	31	opportunity	opportunity	NOUN
bjp-23604	110	32	to	to	PART
bjp-23604	110	33	limit	limit	VERB
bjp-23604	110	34	the	the	DET
bjp-23604	110	35	development	development	NOUN
bjp-23604	110	36	of	of	ADP
bjp-23604	110	37	resistance	resistance	NOUN
bjp-23604	110	38	to	to	ADP
bjp-23604	110	39	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	110	40	.	.	PUNCT
bjp-23604	111	1	low	low	ADJ
bjp-23604	111	2	concentrations	concentration	NOUN
bjp-23604	111	3	at	at	ADP
bjp-23604	111	4	the	the	DET
bjp-23604	111	5	end	end	NOUN
bjp-23604	111	6	of	of	ADP
bjp-23604	111	7	the	the	DET
bjp-23604	111	8	dosing	dosing	NOUN
bjp-23604	111	9	interval	interval	NOUN
bjp-23604	111	10	may	may	AUX
bjp-23604	111	11	promote	promote	VERB
bjp-23604	111	12	bacterial	bacterial	ADJ
bjp-23604	111	13	resistance	resistance	NOUN
bjp-23604	111	14	.	.	PUNCT
bjp-23604	112	1	the	the	DET
bjp-23604	112	2	concept	concept	NOUN
bjp-23604	112	3	of	of	ADP
bjp-23604	112	4	mutant	mutant	ADJ
bjp-23604	112	5	prevention	prevention	NOUN
bjp-23604	112	6	concentration	concentration	NOUN
bjp-23604	112	7	refers	refer	VERB
bjp-23604	112	8	to	to	ADP
bjp-23604	112	9	the	the	DET
bjp-23604	112	10	concentration	concentration	NOUN
bjp-23604	112	11	that	that	PRON
bjp-23604	112	12	prevents	prevent	VERB
bjp-23604	112	13	the	the	DET
bjp-23604	112	14	growth	growth	NOUN
bjp-23604	112	15	of	of	ADP
bjp-23604	112	16	not	not	PART
bjp-23604	112	17	only	only	ADV
bjp-23604	112	18	fully	fully	ADV
bjp-23604	112	19	susceptible	susceptible	ADJ
bjp-23604	112	20	,	,	PUNCT
bjp-23604	112	21	but	but	CCONJ
bjp-23604	112	22	also	also	ADV
bjp-23604	112	23	low	low	ADJ
bjp-23604	112	24	resistant	resistant	ADJ
bjp-23604	112	25	strains	strain	NOUN
bjp-23604	112	26	(	(	PUNCT
bjp-23604	112	27	blondeau	blondeau	NOUN
bjp-23604	112	28	et	et	PROPN
bjp-23604	112	29	al	al	PROPN
bjp-23604	112	30	.	.	PROPN
bjp-23604	112	31	,	,	PUNCT
bjp-23604	112	32	2004	2004	NUM
bjp-23604	112	33	;	;	PUNCT
bjp-23604	112	34	olofsson	olofsson	NOUN
bjp-23604	112	35	et	et	PROPN
bjp-23604	112	36	al	al	PROPN
bjp-23604	112	37	.	.	PROPN
bjp-23604	112	38	,	,	PUNCT
bjp-23604	112	39	2006	2006	NUM
bjp-23604	112	40	)	)	PUNCT
bjp-23604	112	41	.	.	PUNCT
bjp-23604	113	1	keeping	keep	VERB
bjp-23604	113	2	the	the	DET
bjp-23604	113	3	concentration	concentration	NOUN
bjp-23604	113	4	of	of	ADP
bjp-23604	113	5	drug	drug	NOUN
bjp-23604	113	6	above	above	ADP
bjp-23604	113	7	the	the	DET
bjp-23604	113	8	mutant	mutant	ADJ
bjp-23604	113	9	prevention	prevention	NOUN
bjp-23604	113	10	concentration	concentration	NOUN
bjp-23604	113	11	during	during	ADP
bjp-23604	113	12	entire	entire	ADJ
bjp-23604	113	13	dosing	dosing	ADJ
bjp-23604	113	14	interval	interval	NOUN
bjp-23604	113	15	and	and	CCONJ
bjp-23604	113	16	providing	provide	VERB
bjp-23604	113	17	auc	auc	NOUN
bjp-23604	113	18	/	/	SYM
bjp-23604	113	19	mic	mic	ADJ
bjp-23604	113	20	ratios	ratio	NOUN
bjp-23604	113	21	as	as	ADV
bjp-23604	113	22	high	high	ADJ
bjp-23604	113	23	as	as	ADP
bjp-23604	113	24	possible	possible	ADJ
bjp-23604	113	25	reduces	reduce	VERB
bjp-23604	113	26	the	the	DET
bjp-23604	113	27	potential	potential	NOUN
bjp-23604	113	28	of	of	ADP
bjp-23604	113	29	resistance	resistance	NOUN
bjp-23604	113	30	selection	selection	NOUN
bjp-23604	113	31	(	(	PUNCT
bjp-23604	113	32	firsov	firsov	NOUN
bjp-23604	113	33	et	et	PROPN
bjp-23604	113	34	al	al	PROPN
bjp-23604	113	35	.	.	PROPN
bjp-23604	113	36	,	,	PUNCT
bjp-23604	113	37	2003	2003	NUM
bjp-23604	113	38	)	)	PUNCT
bjp-23604	113	39	.	.	PUNCT
bjp-23604	114	1	conclusion	conclusion	NOUN
bjp-23604	114	2	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	114	3	in	in	ADP
bjp-23604	114	4	standard	standard	ADJ
bjp-23604	114	5	dosing	dose	VERB
bjp-23604	114	6	regimen	regiman	NOUN
bjp-23604	114	7	remains	remain	VERB
bjp-23604	114	8	a	a	DET
bjp-23604	114	9	good	good	ADJ
bjp-23604	114	10	choice	choice	NOUN
bjp-23604	114	11	of	of	ADP
bjp-23604	114	12	antibiotic	antibiotic	NOUN
bjp-23604	114	13	for	for	ADP
bjp-23604	114	14	treatment	treatment	NOUN
bjp-23604	114	15	of	of	ADP
bjp-23604	114	16	complicated	complicated	ADJ
bjp-23604	114	17	urinary	urinary	ADJ
bjp-23604	114	18	tract	tract	NOUN
bjp-23604	114	19	caused	cause	VERB
bjp-23604	114	20	by	by	ADP
bjp-23604	114	21	susceptible	susceptible	ADJ
bjp-23604	114	22	gram	gram	NOUN
bjp-23604	114	23	negative	negative	ADJ
bjp-23604	114	24	microorganisms	microorganism	NOUN
bjp-23604	114	25	,	,	PUNCT
bjp-23604	114	26	but	but	CCONJ
bjp-23604	114	27	in	in	ADP
bjp-23604	114	28	severe	severe	ADJ
bjp-23604	114	29	,	,	PUNCT
bjp-23604	114	30	recurrent	recurrent	ADJ
bjp-23604	114	31	or	or	CCONJ
bjp-23604	114	32	chronic	chronic	ADJ
bjp-23604	114	33	infections	infection	NOUN
bjp-23604	114	34	,	,	PUNCT
bjp-23604	114	35	especially	especially	ADV
bjp-23604	114	36	those	those	PRON
bjp-23604	114	37	caused	cause	VERB
bjp-23604	114	38	by	by	ADP
bjp-23604	114	39	gram	gram	NOUN
bjp-23604	114	40	positive	positive	ADJ
bjp-23604	114	41	bacteria	bacteria	NOUN
bjp-23604	114	42	which	which	PRON
bjp-23604	114	43	often	often	ADV
bjp-23604	114	44	have	have	VERB
bjp-23604	114	45	higher	high	ADJ
bjp-23604	114	46	mic	mic	ADJ
bjp-23604	114	47	values	value	NOUN
bjp-23604	114	48	,	,	PUNCT
bjp-23604	114	49	deeper	deep	ADJ
bjp-23604	114	50	analysis	analysis	NOUN
bjp-23604	114	51	is	be	AUX
bjp-23604	114	52	necessary	necessary	ADJ
bjp-23604	114	53	in	in	ADP
bjp-23604	114	54	order	order	NOUN
bjp-23604	114	55	to	to	PART
bjp-23604	114	56	achieve	achieve	VERB
bjp-23604	114	57	optimal	optimal	ADJ
bjp-23604	114	58	results	result	NOUN
bjp-23604	114	59	.	.	PUNCT
bjp-23604	115	1	acknowledgement	acknowledgement	NOUN
bjp-23604	115	2	this	this	DET
bjp-23604	115	3	work	work	NOUN
bjp-23604	115	4	was	be	AUX
bjp-23604	115	5	supported	support	VERB
bjp-23604	115	6	by	by	ADP
bjp-23604	115	7	the	the	DET
bjp-23604	115	8	ministry	ministry	PROPN
bjp-23604	115	9	of	of	ADP
bjp-23604	115	10	science	science	NOUN
bjp-23604	115	11	and	and	CCONJ
bjp-23604	115	12	technological	technological	ADJ
bjp-23604	115	13	development	development	NOUN
bjp-23604	115	14	of	of	ADP
bjp-23604	115	15	serbia	serbia	PROPN
bjp-23604	115	16	project	project	VERB
bjp-23604	115	17	no	no	INTJ
bjp-23604	115	18	.	.	PUNCT
bjp-23604	116	1	iii	iii	PROPN
bjp-23604	116	2	41012	41012	NUM
bjp-23604	116	3	.	.	PUNCT
bjp-23604	117	1	references	reference	NOUN
bjp-23604	117	2	ambrose	ambrose	PROPN
bjp-23604	117	3	pg	pg	PROPN
bjp-23604	117	4	.	.	PUNCT
bjp-23604	118	1	antimicrobial	antimicrobial	ADJ
bjp-23604	118	2	susceptibility	susceptibility	NOUN
bjp-23604	118	3	breakpoints	breakpoint	NOUN
bjp-23604	118	4	:	:	PUNCT
bjp-23604	118	5	pk	pk	NOUN
bjp-23604	118	6	-	-	ADJ
bjp-23604	118	7	pd	pd	NOUN
bjp-23604	118	8	and	and	CCONJ
bjp-23604	118	9	susceptibility	susceptibility	NOUN
bjp-23604	118	10	breakpoints	breakpoint	NOUN
bjp-23604	118	11	.	.	PUNCT
bjp-23604	119	1	treat	treat	AUX
bjp-23604	119	2	respir	respir	VERB
bjp-23604	119	3	med	med	ADJ
bjp-23604	119	4	.	.	PUNCT
bjp-23604	119	5	2005	2005	NUM
bjp-23604	119	6	;	;	PUNCT
bjp-23604	119	7	4	4	NUM
bjp-23604	119	8	(	(	PUNCT
bjp-23604	119	9	suppl	suppl	NOUN
bjp-23604	119	10	1	1	NUM
bjp-23604	119	11	):	):	PUNCT
bjp-23604	119	12	5	5	NUM
bjp-23604	119	13	-	-	SYM
bjp-23604	119	14	11	11	NUM
bjp-23604	119	15	.	.	PUNCT
bjp-23604	120	1	barber	barber	PROPN
bjp-23604	120	2	a	a	PROPN
bjp-23604	120	3	,	,	PUNCT
bjp-23604	120	4	norton	norton	PROPN
bjp-23604	120	5	j	j	PROPN
bjp-23604	120	6	,	,	PUNCT
bjp-23604	120	7	spivak	spivak	PROPN
bjp-23604	120	8	a	a	PROPN
bjp-23604	120	9	,	,	PUNCT
bjp-23604	120	10	mulvey	mulvey	PROPN
bjp-23604	120	11	m.	m.	NOUN
bjp-23604	120	12	urinary	urinary	ADJ
bjp-23604	120	13	tract	tract	NOUN
bjp-23604	120	14	infections	infection	NOUN
bjp-23604	120	15	:	:	PUNCT
bjp-23604	120	16	current	current	ADJ
bjp-23604	120	17	and	and	CCONJ
bjp-23604	120	18	emerging	emerge	VERB
bjp-23604	120	19	management	management	NOUN
bjp-23604	120	20	strategies	strategy	NOUN
bjp-23604	120	21	.	.	PUNCT
bjp-23604	121	1	clin	clin	PROPN
bjp-23604	121	2	infect	infect	PROPN
bjp-23604	121	3	dis	dis	PROPN
bjp-23604	121	4	.	.	PUNCT
bjp-23604	122	1	2013	2013	NUM
bjp-23604	122	2	;	;	PUNCT
bjp-23604	122	3	57	57	NUM
bjp-23604	122	4	:	:	SYM
bjp-23604	122	5	719	719	NUM
bjp-23604	122	6	-	-	SYM
bjp-23604	122	7	24	24	NUM
bjp-23604	122	8	.	.	PUNCT
bjp-23604	123	1	blondeau	blondeau	PROPN
bjp-23604	123	2	j	j	PROPN
bjp-23604	123	3	,	,	PUNCT
bjp-23604	123	4	hansen	hansen	PROPN
bjp-23604	123	5	g	g	PROPN
bjp-23604	123	6	,	,	PUNCT
bjp-23604	123	7	metzler	metzler	PROPN
bjp-23604	123	8	k	k	PROPN
bjp-23604	123	9	,	,	PUNCT
bjp-23604	123	10	hedlin	hedlin	PROPN
bjp-23604	123	11	p.	p.	PROPN
bjp-23604	124	1	the	the	DET
bjp-23604	124	2	role	role	NOUN
bjp-23604	124	3	of	of	ADP
bjp-23604	124	4	pk	pk	PROPN
bjp-23604	124	5	/	/	SYM
bjp-23604	124	6	pd	pd	NOUN
bjp-23604	124	7	parameters	parameter	NOUN
bjp-23604	124	8	to	to	PART
bjp-23604	124	9	avoid	avoid	VERB
bjp-23604	124	10	selection	selection	NOUN
bjp-23604	124	11	and	and	CCONJ
bjp-23604	124	12	increase	increase	NOUN
bjp-23604	124	13	of	of	ADP
bjp-23604	124	14	resistance	resistance	NOUN
bjp-23604	124	15	:	:	PUNCT
bjp-23604	124	16	mutant	mutant	ADJ
bjp-23604	124	17	prevention	prevention	NOUN
bjp-23604	124	18	concentration	concentration	NOUN
bjp-23604	124	19	.	.	PUNCT
bjp-23604	125	1	j	j	PROPN
bjp-23604	125	2	chemother	chemother	PROPN
bjp-23604	125	3	.	.	PUNCT
bjp-23604	126	1	2004	2004	NUM
bjp-23604	126	2	;	;	PUNCT
bjp-23604	126	3	16	16	NUM
bjp-23604	126	4	(	(	PUNCT
bjp-23604	126	5	suppl	suppl	NOUN
bjp-23604	126	6	3	3	NUM
bjp-23604	126	7	):	):	PUNCT
bjp-23604	126	8	1	1	NUM
bjp-23604	126	9	-	-	SYM
bjp-23604	126	10	19	19	NUM
bjp-23604	126	11	.	.	PUNCT
bjp-23604	127	1	chen	chen	PROPN
bjp-23604	127	2	yh	yh	PROPN
bjp-23604	127	3	,	,	PUNCT
bjp-23604	127	4	ko	ko	PROPN
bjp-23604	127	5	wc	wc	PROPN
bjp-23604	127	6	,	,	PUNCT
bjp-23604	127	7	hsueh	hsueh	PROPN
bjp-23604	127	8	pr	pr	PROPN
bjp-23604	127	9	.	.	PUNCT
bjp-23604	128	1	emerging	emerge	VERB
bjp-23604	128	2	resistance	resistance	NOUN
bjp-23604	128	3	problems	problem	NOUN
bjp-23604	128	4	and	and	CCONJ
bjp-23604	128	5	future	future	ADJ
bjp-23604	128	6	perspectives	perspective	NOUN
bjp-23604	128	7	in	in	ADP
bjp-23604	128	8	pharmacotherapy	pharmacotherapy	NOUN
bjp-23604	128	9	for	for	ADP
bjp-23604	128	10	complicated	complicated	ADJ
bjp-23604	128	11	urinary	urinary	ADJ
bjp-23604	128	12	tract	tract	NOUN
bjp-23604	128	13	infections	infection	NOUN
bjp-23604	128	14	.	.	PUNCT
bjp-23604	129	1	expert	expert	NOUN
bjp-23604	129	2	opin	opin	NOUN
bjp-23604	129	3	pharmacother	pharmacother	NOUN
bjp-23604	129	4	.	.	PUNCT
bjp-23604	130	1	2013	2013	NUM
bjp-23604	130	2	;	;	PUNCT
bjp-23604	130	3	14	14	NUM
bjp-23604	130	4	:	:	SYM
bjp-23604	130	5	587	587	NUM
bjp-23604	130	6	-	-	SYM
bjp-23604	130	7	96	96	NUM
bjp-23604	130	8	.	.	PUNCT
bjp-23604	131	1	clinical	clinical	ADJ
bjp-23604	131	2	and	and	CCONJ
bjp-23604	131	3	laboratory	laboratory	NOUN
bjp-23604	131	4	standards	standards	PROPN
bjp-23604	131	5	institute	institute	PROPN
bjp-23604	131	6	.	.	PUNCT
bjp-23604	132	1	methods	method	NOUN
bjp-23604	132	2	for	for	ADP
bjp-23604	132	3	dilution	dilution	NOUN
bjp-23604	132	4	antimicrobial	antimicrobial	ADJ
bjp-23604	132	5	susceptibility	susceptibility	NOUN
bjp-23604	132	6	tests	test	VERB
bjp-23604	132	7	for	for	ADP
bjp-23604	132	8	bacteria	bacteria	NOUN
bjp-23604	132	9	that	that	PRON
bjp-23604	132	10	grow	grow	VERB
bjp-23604	132	11	aerobically	aerobically	ADV
bjp-23604	132	12	:	:	PUNCT
bjp-23604	132	13	approved	approve	VERB
bjp-23604	132	14	standard	standard	NOUN
bjp-23604	132	15	.	.	PUNCT
bjp-23604	133	1	7th	7th	ADJ
bjp-23604	133	2	ed	ed	NOUN
bjp-23604	133	3	.	.	PUNCT
bjp-23604	134	1	clinical	clinical	ADJ
bjp-23604	134	2	and	and	CCONJ
bjp-23604	134	3	laboratory	laboratory	NOUN
bjp-23604	134	4	standards	standard	NOUN
bjp-23604	134	5	institute	institute	PROPN
bjp-23604	134	6	document	document	NOUN
bjp-23604	134	7	m7	m7	PROPN
bjp-23604	134	8	-	-	PUNCT
bjp-23604	134	9	a7	a7	PROPN
bjp-23604	134	10	.	.	PUNCT
bjp-23604	135	1	clinical	clinical	ADJ
bjp-23604	135	2	and	and	CCONJ
bjp-23604	135	3	laboratory	laboratory	NOUN
bjp-23604	135	4	standards	standard	NOUN
bjp-23604	135	5	institute	institute	PROPN
bjp-23604	135	6	,	,	PUNCT
bjp-23604	135	7	2006	2006	NUM
bjp-23604	135	8	.	.	PUNCT
bjp-23604	136	1	bangladesh	bangladesh	PROPN
bjp-23604	136	2	j	j	PROPN
bjp-23604	136	3	pharmacol	pharmacol	PROPN
bjp-23604	136	4	2015	2015	NUM
bjp-23604	136	5	;	;	PUNCT
bjp-23604	136	6	10	10	NUM
bjp-23604	136	7	:	:	SYM
bjp-23604	136	8	621	621	NUM
bjp-23604	136	9	-	-	SYM
bjp-23604	136	10	626	626	NUM
bjp-23604	136	11	625	625	NUM
bjp-23604	136	12	author	author	NOUN
bjp-23604	136	13	info	info	NOUN
bjp-23604	136	14	ana	ana	PROPN
bjp-23604	136	15	tomas	tomas	PROPN
bjp-23604	136	16	(	(	PUNCT
bjp-23604	136	17	principal	principal	ADJ
bjp-23604	136	18	contact	contact	NOUN
bjp-23604	136	19	)	)	PUNCT
bjp-23604	137	1	e	e	NOUN
bjp-23604	137	2	-	-	NOUN
bjp-23604	137	3	mail	mail	NOUN
bjp-23604	137	4	:	:	PUNCT
bjp-23604	137	5	aanaa_tomas@yahoo.com	aanaa_tomas@yahoo.com	PROPN
bjp-23604	137	6	;	;	PUNCT
bjp-23604	137	7	tel	tel	PROPN
bjp-23604	137	8	:	:	PUNCT
bjp-23604	137	9	+38121522172	+38121522172	NUM
bjp-23604	137	10	craig	craig	PROPN
bjp-23604	137	11	wa	wa	PROPN
bjp-23604	137	12	.	.	PROPN
bjp-23604	137	13	does	do	VERB
bjp-23604	137	14	the	the	DET
bjp-23604	137	15	dose	dose	NOUN
bjp-23604	137	16	matter	matter	NOUN
bjp-23604	137	17	?	?	PUNCT
bjp-23604	138	1	clin	clin	PROPN
bjp-23604	138	2	infect	infect	PROPN
bjp-23604	138	3	dis	dis	PROPN
bjp-23604	138	4	.	.	PUNCT
bjp-23604	139	1	2001	2001	NUM
bjp-23604	139	2	;	;	PUNCT
bjp-23604	139	3	33	33	NUM
bjp-23604	139	4	(	(	PUNCT
bjp-23604	139	5	suppl	suppl	NOUN
bjp-23604	139	6	3	3	NUM
bjp-23604	139	7	):	):	PUNCT
bjp-23604	139	8	233	233	NUM
bjp-23604	139	9	-	-	SYM
bjp-23604	139	10	37	37	NUM
bjp-23604	139	11	.	.	PUNCT
bjp-23604	140	1	craig	craig	PROPN
bjp-23604	140	2	wa	wa	PROPN
bjp-23604	140	3	,	,	PUNCT
bjp-23604	140	4	gudmundsson	gudmundsson	PROPN
bjp-23604	140	5	s	s	PART
bjp-23604	140	6	:	:	PUNCT
bjp-23604	140	7	postantibiotic	postantibiotic	ADJ
bjp-23604	140	8	effect	effect	NOUN
bjp-23604	140	9	.	.	PUNCT
bjp-23604	141	1	in	in	ADP
bjp-23604	141	2	:	:	PUNCT
bjp-23604	141	3	antibiotics	antibiotic	NOUN
bjp-23604	141	4	in	in	ADP
bjp-23604	141	5	laboratory	laboratory	NOUN
bjp-23604	141	6	medicine	medicine	NOUN
bjp-23604	141	7	.	.	PUNCT
bjp-23604	142	1	4th	4th	ADJ
bjp-23604	142	2	ed	ed	NOUN
bjp-23604	142	3	.	.	PUNCT
bjp-23604	143	1	baltimore	baltimore	PROPN
bjp-23604	143	2	md	md	PROPN
bjp-23604	143	3	,	,	PUNCT
bjp-23604	143	4	williams	williams	PROPN
bjp-23604	143	5	&	&	CCONJ
bjp-23604	143	6	wilkins	wilkins	PROPN
bjp-23604	143	7	,	,	PUNCT
bjp-23604	143	8	1996	1996	NUM
bjp-23604	143	9	,	,	PUNCT
bjp-23604	143	10	pp	pp	ADP
bjp-23604	143	11	296–329	296–329	NUM
bjp-23604	143	12	.	.	PUNCT
bjp-23604	144	1	daoud	daoud	PROPN
bjp-23604	144	2	z	z	PROPN
bjp-23604	144	3	,	,	PUNCT
bjp-23604	144	4	sokhn	sokhn	PROPN
bjp-23604	144	5	es	es	PROPN
bjp-23604	144	6	,	,	PUNCT
bjp-23604	144	7	azar	azar	PROPN
bjp-23604	144	8	e	e	PROPN
bjp-23604	144	9	,	,	PUNCT
bjp-23604	144	10	masri	masri	PROPN
bjp-23604	144	11	k	k	PROPN
bjp-23604	144	12	,	,	PUNCT
bjp-23604	144	13	doron	doron	PROPN
bjp-23604	144	14	s.	s.	PROPN
bjp-23604	144	15	mutant	mutant	PROPN
bjp-23604	144	16	prevention	prevention	NOUN
bjp-23604	144	17	concentrations	concentration	NOUN
bjp-23604	144	18	of	of	ADP
bjp-23604	144	19	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	144	20	against	against	ADP
bjp-23604	144	21	urinary	urinary	ADJ
bjp-23604	144	22	isolates	isolate	NOUN
bjp-23604	144	23	of	of	ADP
bjp-23604	144	24	escherichia	escherichia	NOUN
bjp-23604	144	25	coli	coli	NOUN
bjp-23604	144	26	and	and	CCONJ
bjp-23604	144	27	klebsiella	klebsiella	NOUN
bjp-23604	144	28	pneumonia	pneumonia	NOUN
bjp-23604	144	29	.	.	PUNCT
bjp-23604	145	1	j	j	PROPN
bjp-23604	145	2	infect	infect	PROPN
bjp-23604	145	3	dev	dev	PROPN
bjp-23604	145	4	ctries	ctrie	NOUN
bjp-23604	145	5	.	.	PUNCT
bjp-23604	146	1	2014	2014	NUM
bjp-23604	146	2	;	;	PUNCT
bjp-23604	146	3	8	8	NUM
bjp-23604	146	4	:	:	SYM
bjp-23604	146	5	154	154	NUM
bjp-23604	146	6	-	-	SYM
bjp-23604	146	7	59	59	NUM
bjp-23604	146	8	.	.	PUNCT
bjp-23604	147	1	drusano	drusano	PROPN
bjp-23604	147	2	g	g	PROPN
bjp-23604	147	3	l	l	PROPN
bjp-23604	147	4	,	,	PUNCT
bjp-23604	147	5	preston	preston	PROPN
bjp-23604	147	6	s	s	PROPN
bjp-23604	147	7	,	,	PUNCT
bjp-23604	147	8	fowler	fowler	PROPN
bjp-23604	147	9	c	c	PROPN
bjp-23604	147	10	,	,	PUNCT
bjp-23604	147	11	corrado	corrado	PROPN
bjp-23604	147	12	m	m	PROPN
bjp-23604	147	13	,	,	PUNCT
bjp-23604	147	14	weisinger	weisinger	PROPN
bjp-23604	147	15	b	b	PROPN
bjp-23604	147	16	,	,	PUNCT
bjp-23604	147	17	kahn	kahn	PROPN
bjp-23604	147	18	j	j	PROPN
bjp-23604	147	19	:	:	PUNCT
bjp-23604	147	20	relationship	relationship	NOUN
bjp-23604	147	21	between	between	ADP
bjp-23604	147	22	fluoroquinolone	fluoroquinolone	NOUN
bjp-23604	147	23	area	area	NOUN
bjp-23604	147	24	under	under	ADP
bjp-23604	147	25	the	the	DET
bjp-23604	147	26	curve	curve	NOUN
bjp-23604	147	27	:	:	PUNCT
bjp-23604	147	28	minimum	minimum	ADJ
bjp-23604	147	29	inhibitory	inhibitory	ADJ
bjp-23604	147	30	concentration	concentration	NOUN
bjp-23604	147	31	ratio	ratio	NOUN
bjp-23604	147	32	and	and	CCONJ
bjp-23604	147	33	the	the	DET
bjp-23604	147	34	probability	probability	NOUN
bjp-23604	147	35	of	of	ADP
bjp-23604	147	36	eradication	eradication	NOUN
bjp-23604	147	37	of	of	ADP
bjp-23604	147	38	the	the	DET
bjp-23604	147	39	infecting	infect	VERB
bjp-23604	147	40	pathogen	pathogen	NOUN
bjp-23604	147	41	,	,	PUNCT
bjp-23604	147	42	in	in	ADP
bjp-23604	147	43	patients	patient	NOUN
bjp-23604	147	44	with	with	ADP
bjp-23604	147	45	nosocomial	nosocomial	ADJ
bjp-23604	147	46	pneumonia	pneumonia	NOUN
bjp-23604	147	47	.	.	PUNCT
bjp-23604	148	1	j	j	PROPN
bjp-23604	148	2	infect	infect	VERB
bjp-23604	148	3	dis	dis	PROPN
bjp-23604	148	4	.	.	PUNCT
bjp-23604	149	1	2004	2004	NUM
bjp-23604	149	2	;	;	PUNCT
bjp-23604	149	3	189	189	NUM
bjp-23604	149	4	:	:	PUNCT
bjp-23604	149	5	1590	1590	NUM
bjp-23604	149	6	-	-	SYM
bjp-23604	149	7	97	97	NUM
bjp-23604	149	8	.	.	PUNCT
bjp-23604	150	1	finch	finch	PROPN
bjp-23604	150	2	r.	r.	PROPN
bjp-23604	150	3	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	150	4	:	:	PUNCT
bjp-23604	150	5	efficacy	efficacy	NOUN
bjp-23604	150	6	and	and	CCONJ
bjp-23604	150	7	indications	indication	NOUN
bjp-23604	150	8	.	.	PUNCT
bjp-23604	151	1	j	j	PROPN
bjp-23604	151	2	chemother	chemother	PROPN
bjp-23604	151	3	.	.	PUNCT
bjp-23604	152	1	2000	2000	NUM
bjp-23604	152	2	;	;	PUNCT
bjp-23604	152	3	12	12	NUM
bjp-23604	152	4	suppl	suppl	ADJ
bjp-23604	152	5	:	:	PUNCT
bjp-23604	152	6	15	15	NUM
bjp-23604	152	7	-	-	SYM
bjp-23604	152	8	17	17	NUM
bjp-23604	152	9	.	.	PUNCT
bjp-23604	153	1	firsov	firsov	PROPN
bjp-23604	153	2	a	a	PRON
bjp-23604	153	3	,	,	PUNCT
bjp-23604	153	4	vostrov	vostrov	PROPN
bjp-23604	153	5	s	s	PROPN
bjp-23604	153	6	,	,	PUNCT
bjp-23604	153	7	lubenko	lubenko	ADJ
bjp-23604	153	8	i	i	PRON
bjp-23604	153	9	,	,	PUNCT
bjp-23604	153	10	drlica	drlica	PROPN
bjp-23604	153	11	k	k	PROPN
bjp-23604	153	12	,	,	PUNCT
bjp-23604	153	13	portnoy	portnoy	PROPN
bjp-23604	153	14	y	y	PROPN
bjp-23604	153	15	,	,	PUNCT
bjp-23604	153	16	zinner	zinner	NOUN
bjp-23604	153	17	s	s	PART
bjp-23604	153	18	:	:	PUNCT
bjp-23604	153	19	in	in	ADV
bjp-23604	153	20	vitro	vitro	X
bjp-23604	153	21	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	153	22	evaluation	evaluation	NOUN
bjp-23604	153	23	of	of	ADP
bjp-23604	153	24	the	the	DET
bjp-23604	153	25	mutant	mutant	ADJ
bjp-23604	153	26	selection	selection	NOUN
bjp-23604	153	27	window	window	NOUN
bjp-23604	153	28	hypothesis	hypothesis	NOUN
bjp-23604	153	29	using	use	VERB
bjp-23604	153	30	four	four	NUM
bjp-23604	153	31	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	153	32	against	against	ADP
bjp-23604	153	33	staphylococcus	staphylococcus	NOUN
bjp-23604	153	34	aureus	aureus	NOUN
bjp-23604	153	35	.	.	PUNCT
bjp-23604	154	1	antimicrob	antimicrob	PROPN
bjp-23604	154	2	agents	agents	PROPN
bjp-23604	154	3	chemother	chemother	PROPN
bjp-23604	154	4	.	.	PUNCT
bjp-23604	155	1	2003	2003	NUM
bjp-23604	155	2	;	;	PUNCT
bjp-23604	155	3	47	47	NUM
bjp-23604	155	4	:	:	PUNCT
bjp-23604	155	5	1604	1604	NUM
bjp-23604	155	6	-	-	SYM
bjp-23604	155	7	13	13	NUM
bjp-23604	155	8	.	.	PUNCT
bjp-23604	156	1	forrest	forrest	PROPN
bjp-23604	156	2	a	a	PRON
bjp-23604	156	3	,	,	PUNCT
bjp-23604	156	4	nix	nix	PROPN
bjp-23604	156	5	de	de	PROPN
bjp-23604	156	6	,	,	PUNCT
bjp-23604	156	7	ballow	ballow	NOUN
bjp-23604	156	8	ch	ch	PROPN
bjp-23604	156	9	,	,	PUNCT
bjp-23604	156	10	goss	goss	PROPN
bjp-23604	156	11	tf	tf	PROPN
bjp-23604	156	12	,	,	PUNCT
bjp-23604	156	13	birmingham	birmingham	PROPN
bjp-23604	156	14	mc	mc	PROPN
bjp-23604	156	15	,	,	PUNCT
bjp-23604	156	16	schentag	schentag	PROPN
bjp-23604	156	17	jj	jj	PROPN
bjp-23604	156	18	.	.	PROPN
bjp-23604	156	19	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	156	20	of	of	ADP
bjp-23604	156	21	intravenous	intravenous	ADJ
bjp-23604	156	22	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	156	23	in	in	ADP
bjp-23604	156	24	seriously	seriously	ADV
bjp-23604	156	25	ill	ill	ADJ
bjp-23604	156	26	patients	patient	NOUN
bjp-23604	156	27	.	.	PUNCT
bjp-23604	157	1	antimicrob	antimicrob	PROPN
bjp-23604	157	2	agents	agents	PROPN
bjp-23604	157	3	chemother	chemother	PROPN
bjp-23604	157	4	.	.	PUNCT
bjp-23604	158	1	1993	1993	NUM
bjp-23604	158	2	;	;	PUNCT
bjp-23604	158	3	37	37	NUM
bjp-23604	158	4	:	:	SYM
bjp-23604	158	5	1073	1073	NUM
bjp-23604	158	6	-	-	SYM
bjp-23604	158	7	81	81	NUM
bjp-23604	158	8	.	.	PUNCT
bjp-23604	159	1	jacobs	jacobs	PROPN
bjp-23604	159	2	mr	mr	PROPN
bjp-23604	159	3	.	.	PROPN
bjp-23604	159	4	optimisation	optimisation	NOUN
bjp-23604	159	5	of	of	ADP
bjp-23604	159	6	antimicrobial	antimicrobial	ADJ
bjp-23604	159	7	therapy	therapy	NOUN
bjp-23604	159	8	using	use	VERB
bjp-23604	159	9	pharmacokinetic	pharmacokinetic	ADJ
bjp-23604	159	10	and	and	CCONJ
bjp-23604	159	11	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	159	12	parameters	parameter	NOUN
bjp-23604	159	13	.	.	PUNCT
bjp-23604	160	1	clin	clin	PROPN
bjp-23604	160	2	microbiol	microbiol	PROPN
bjp-23604	160	3	infect	infect	PROPN
bjp-23604	160	4	.	.	PUNCT
bjp-23604	161	1	2001	2001	NUM
bjp-23604	161	2	;	;	PUNCT
bjp-23604	161	3	7	7	NUM
bjp-23604	161	4	:	:	SYM
bjp-23604	161	5	589	589	NUM
bjp-23604	161	6	-	-	SYM
bjp-23604	161	7	96	96	NUM
bjp-23604	161	8	.	.	PUNCT
bjp-23604	162	1	krcmery	krcmery	PROPN
bjp-23604	162	2	s	s	PROPN
bjp-23604	162	3	,	,	PUNCT
bjp-23604	162	4	naber	naber	PROPN
bjp-23604	162	5	kg	kg	PROPN
bjp-23604	162	6	.	.	PUNCT
bjp-23604	163	1	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	163	2	once	once	ADV
bjp-23604	163	3	versus	versus	ADP
bjp-23604	163	4	twice	twice	ADV
bjp-23604	163	5	daily	daily	ADV
bjp-23604	163	6	in	in	ADP
bjp-23604	163	7	the	the	DET
bjp-23604	163	8	treatment	treatment	NOUN
bjp-23604	163	9	of	of	ADP
bjp-23604	163	10	complicated	complicated	ADJ
bjp-23604	163	11	urinary	urinary	ADJ
bjp-23604	163	12	tract	tract	NOUN
bjp-23604	163	13	infections	infection	NOUN
bjp-23604	163	14	.	.	PUNCT
bjp-23604	164	1	int	int	NOUN
bjp-23604	164	2	j	j	PROPN
bjp-23604	164	3	antimicrob	antimicrob	PROPN
bjp-23604	164	4	agents	agent	NOUN
bjp-23604	164	5	.	.	PUNCT
bjp-23604	165	1	1999	1999	NUM
bjp-23604	165	2	;	;	PUNCT
bjp-23604	165	3	11	11	NUM
bjp-23604	165	4	:	:	SYM
bjp-23604	165	5	133	133	NUM
bjp-23604	165	6	-	-	SYM
bjp-23604	165	7	38	38	NUM
bjp-23604	165	8	.	.	PUNCT
bjp-23604	166	1	licata	licata	PROPN
bjp-23604	166	2	l	l	PROPN
bjp-23604	166	3	,	,	PUNCT
bjp-23604	166	4	smith	smith	PROPN
bjp-23604	166	5	c	c	PROPN
bjp-23604	166	6	,	,	PUNCT
bjp-23604	166	7	goldschmidt	goldschmidt	NOUN
bjp-23604	166	8	r	r	NOUN
bjp-23604	166	9	,	,	PUNCT
bjp-23604	166	10	barrett	barrett	PROPN
bjp-23604	166	11	j	j	PROPN
bjp-23604	166	12	,	,	PUNCT
bjp-23604	166	13	frosco	frosco	PROPN
bjp-23604	166	14	m.	m.	PROPN
bjp-23604	166	15	comparison	comparison	NOUN
bjp-23604	166	16	of	of	ADP
bjp-23604	166	17	the	the	DET
bjp-23604	166	18	postantibiotic	postantibiotic	ADJ
bjp-23604	166	19	and	and	CCONJ
bjp-23604	166	20	postantibiotic	postantibiotic	ADJ
bjp-23604	166	21	sub	sub	ADJ
bjp-23604	166	22	-	-	ADJ
bjp-23604	166	23	mic	mic	ADJ
bjp-23604	166	24	effects	effect	NOUN
bjp-23604	166	25	of	of	ADP
bjp-23604	166	26	levofloxacin	levofloxacin	NOUN
bjp-23604	166	27	and	and	CCONJ
bjp-23604	166	28	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	166	29	on	on	ADP
bjp-23604	166	30	staphylococcus	staphylococcus	NOUN
bjp-23604	166	31	aureus	aureus	NOUN
bjp-23604	166	32	and	and	CCONJ
bjp-23604	166	33	streptococcus	streptococcus	VERB
bjp-23604	166	34	pneumoniae	pneumoniae	NOUN
bjp-23604	166	35	.	.	PUNCT
bjp-23604	167	1	antimicrob	antimicrob	PROPN
bjp-23604	167	2	agents	agents	PROPN
bjp-23604	167	3	chemother	chemother	PROPN
bjp-23604	167	4	.	.	PUNCT
bjp-23604	168	1	1997	1997	NUM
bjp-23604	168	2	;	;	PUNCT
bjp-23604	168	3	41	41	NUM
bjp-23604	168	4	:	:	SYM
bjp-23604	168	5	950	950	NUM
bjp-23604	168	6	-	-	SYM
bjp-23604	168	7	55	55	NUM
bjp-23604	168	8	.	.	PUNCT
bjp-23604	169	1	minguez	minguez	PROPN
bjp-23604	169	2	f	f	PROPN
bjp-23604	169	3	,	,	PUNCT
bjp-23604	169	4	ramos	ramos	PROPN
bjp-23604	169	5	c	c	PROPN
bjp-23604	169	6	,	,	PUNCT
bjp-23604	169	7	barrientos	barrientos	PROPN
bjp-23604	169	8	s	s	PART
bjp-23604	169	9	,	,	PUNCT
bjp-23604	169	10	loscos	loscos	X
bjp-23604	169	11	a	a	PRON
bjp-23604	169	12	,	,	PUNCT
bjp-23604	169	13	prieto	prieto	NOUN
bjp-23604	169	14	j.	j.	PROPN
bjp-23604	169	15	postantibiotic	postantibiotic	ADJ
bjp-23604	169	16	effect	effect	NOUN
bjp-23604	169	17	of	of	ADP
bjp-23604	169	18	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	169	19	compared	compare	VERB
bjp-23604	169	20	with	with	ADP
bjp-23604	169	21	that	that	PRON
bjp-23604	169	22	of	of	ADP
bjp-23604	169	23	five	five	NUM
bjp-23604	169	24	other	other	ADJ
bjp-23604	169	25	quinolones	quinolone	NOUN
bjp-23604	169	26	.	.	PUNCT
bjp-23604	170	1	chemotherapy	chemotherapy	NOUN
bjp-23604	170	2	1991	1991	NUM
bjp-23604	170	3	;	;	PUNCT
bjp-23604	170	4	37	37	NUM
bjp-23604	170	5	:	:	SYM
bjp-23604	170	6	420	420	NUM
bjp-23604	170	7	-	-	SYM
bjp-23604	170	8	25	25	NUM
bjp-23604	170	9	.	.	PUNCT
bjp-23604	171	1	mouton	mouton	PROPN
bjp-23604	171	2	jw	jw	PROPN
bjp-23604	171	3	,	,	PUNCT
bjp-23604	171	4	brown	brown	ADJ
bjp-23604	171	5	df	df	PROPN
bjp-23604	171	6	,	,	PUNCT
bjp-23604	171	7	apfalter	apfalter	PROPN
bjp-23604	171	8	p	p	NOUN
bjp-23604	171	9	,	,	PUNCT
bjp-23604	171	10	cantón	cantón	NOUN
bjp-23604	171	11	r	r	NOUN
bjp-23604	171	12	,	,	PUNCT
bjp-23604	171	13	giske	giske	PROPN
bjp-23604	171	14	cg	cg	PROPN
bjp-23604	171	15	,	,	PUNCT
bjp-23604	171	16	ivanova	ivanova	PROPN
bjp-23604	171	17	m	m	PROPN
bjp-23604	171	18	,	,	PUNCT
bjp-23604	171	19	macgowan	macgowan	PROPN
bjp-23604	171	20	ap	ap	PROPN
bjp-23604	171	21	,	,	PUNCT
bjp-23604	171	22	rodloff	rodloff	VERB
bjp-23604	171	23	a	a	DET
bjp-23604	171	24	,	,	PUNCT
bjp-23604	171	25	soussy	soussy	PROPN
bjp-23604	171	26	cj	cj	NOUN
bjp-23604	171	27	,	,	PUNCT
bjp-23604	171	28	steinbakk	steinbakk	NOUN
bjp-23604	171	29	m	m	PROPN
bjp-23604	171	30	,	,	PUNCT
bjp-23604	171	31	kahlmeter	kahlmeter	PROPN
bjp-23604	171	32	g.	g.	PROPN
bjp-23604	172	1	the	the	DET
bjp-23604	172	2	role	role	NOUN
bjp-23604	172	3	of	of	ADP
bjp-23604	172	4	pharmacokinetics	pharmacokinetic	NOUN
bjp-23604	172	5	/	/	SYM
bjp-23604	172	6	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	172	7	in	in	ADP
bjp-23604	172	8	setting	set	VERB
bjp-23604	172	9	clinical	clinical	ADJ
bjp-23604	172	10	mic	mic	ADJ
bjp-23604	172	11	breakpoints	breakpoint	NOUN
bjp-23604	172	12	:	:	PUNCT
bjp-23604	172	13	the	the	DET
bjp-23604	172	14	eucast	eucast	ADJ
bjp-23604	172	15	approach	approach	NOUN
bjp-23604	172	16	.	.	PUNCT
bjp-23604	173	1	clin	clin	PROPN
bjp-23604	173	2	microbiol	microbiol	PROPN
bjp-23604	173	3	infect	infect	PROPN
bjp-23604	173	4	.	.	PUNCT
bjp-23604	174	1	2012	2012	NUM
bjp-23604	174	2	;	;	PUNCT
bjp-23604	174	3	18	18	NUM
bjp-23604	174	4	:	:	PUNCT
bjp-23604	174	5	e37	e37	NOUN
bjp-23604	174	6	-	-	PUNCT
bjp-23604	174	7	e45	e45	PROPN
bjp-23604	174	8	.	.	PUNCT
bjp-23604	175	1	mueller	mueller	PROPN
bjp-23604	175	2	m	m	PROPN
bjp-23604	175	3	,	,	PUNCT
bjp-23604	175	4	de	de	X
bjp-23604	175	5	la	la	X
bjp-23604	175	6	pena	pena	PROPN
bjp-23604	175	7	a	a	PROPN
bjp-23604	175	8	,	,	PUNCT
bjp-23604	175	9	derendorf	derendorf	PROPN
bjp-23604	175	10	h.	h.	PROPN
bjp-23604	175	11	issues	issue	NOUN
bjp-23604	175	12	in	in	ADP
bjp-23604	175	13	pharmacokinetics	pharmacokinetic	NOUN
bjp-23604	175	14	and	and	CCONJ
bjp-23604	175	15	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	175	16	of	of	ADP
bjp-23604	175	17	anti	anti	ADJ
bjp-23604	175	18	-	-	ADJ
bjp-23604	175	19	infective	infective	ADJ
bjp-23604	175	20	agents	agent	NOUN
bjp-23604	175	21	:	:	PUNCT
bjp-23604	175	22	kill	kill	VERB
bjp-23604	175	23	curves	curve	NOUN
bjp-23604	175	24	versus	versus	ADP
bjp-23604	175	25	mic	mic	ADJ
bjp-23604	175	26	.	.	PUNCT
bjp-23604	176	1	antimicrob	antimicrob	PROPN
bjp-23604	176	2	agents	agents	PROPN
bjp-23604	176	3	chemother	chemother	PROPN
bjp-23604	176	4	.	.	PUNCT
bjp-23604	177	1	2004	2004	NUM
bjp-23604	177	2	;	;	PUNCT
bjp-23604	177	3	48	48	NUM
bjp-23604	177	4	:	:	PUNCT
bjp-23604	177	5	369–377	369–377	NUM
bjp-23604	177	6	.	.	PUNCT
bjp-23604	178	1	nicolau	nicolau	ADJ
bjp-23604	178	2	p.	p.	NOUN
bjp-23604	178	3	optimizing	optimize	VERB
bjp-23604	178	4	outcomes	outcome	NOUN
bjp-23604	178	5	with	with	ADP
bjp-23604	178	6	antimicrobial	antimicrobial	ADJ
bjp-23604	178	7	therapy	therapy	NOUN
bjp-23604	178	8	through	through	ADP
bjp-23604	178	9	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	178	10	profiling	profiling	NOUN
bjp-23604	178	11	.	.	PUNCT
bjp-23604	179	1	j	j	PROPN
bjp-23604	179	2	infect	infect	PROPN
bjp-23604	179	3	chemother	chemother	PROPN
bjp-23604	179	4	.	.	PUNCT
bjp-23604	180	1	2003	2003	NUM
bjp-23604	180	2	;	;	PUNCT
bjp-23604	180	3	9	9	NUM
bjp-23604	180	4	:	:	SYM
bjp-23604	180	5	292	292	NUM
bjp-23604	180	6	-	-	SYM
bjp-23604	180	7	96	96	NUM
bjp-23604	180	8	.	.	PUNCT
bjp-23604	181	1	nicolle	nicolle	PROPN
bjp-23604	181	2	le	le	PROPN
bjp-23604	181	3	:	:	PUNCT
bjp-23604	181	4	complicated	complicated	ADJ
bjp-23604	181	5	urinary	urinary	ADJ
bjp-23604	181	6	tract	tract	NOUN
bjp-23604	181	7	infections	infection	NOUN
bjp-23604	181	8	in	in	ADP
bjp-23604	181	9	adults	adult	NOUN
bjp-23604	181	10	.	.	PUNCT
bjp-23604	182	1	can	can	AUX
bjp-23604	182	2	j	j	PROPN
bjp-23604	182	3	infect	infect	VERB
bjp-23604	182	4	dis	dis	PROPN
bjp-23604	182	5	med	med	PROPN
bjp-23604	182	6	microbiol	microbiol	PROPN
bjp-23604	182	7	.	.	PUNCT
bjp-23604	183	1	2005	2005	NUM
bjp-23604	183	2	;	;	PUNCT
bjp-23604	183	3	16	16	NUM
bjp-23604	183	4	:	:	SYM
bjp-23604	183	5	349	349	NUM
bjp-23604	183	6	-	-	SYM
bjp-23604	183	7	60	60	NUM
bjp-23604	183	8	.	.	PUNCT
bjp-23604	184	1	olofsson	olofsson	PROPN
bjp-23604	184	2	s	s	PROPN
bjp-23604	184	3	,	,	PUNCT
bjp-23604	184	4	marcusson	marcusson	NOUN
bjp-23604	184	5	l	l	PROPN
bjp-23604	184	6	,	,	PUNCT
bjp-23604	184	7	komp	komp	PROPN
bjp-23604	184	8	lindgren	lindgren	PROPN
bjp-23604	184	9	p	p	PROPN
bjp-23604	184	10	,	,	PUNCT
bjp-23604	184	11	hughes	hughes	PROPN
bjp-23604	184	12	d	d	PROPN
bjp-23604	184	13	,	,	PUNCT
bjp-23604	184	14	cars	car	NOUN
bjp-23604	184	15	o.	o.	NOUN
bjp-23604	184	16	selection	selection	NOUN
bjp-23604	184	17	of	of	ADP
bjp-23604	184	18	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	184	19	resistance	resistance	NOUN
bjp-23604	184	20	in	in	ADP
bjp-23604	184	21	escherichia	escherichia	NOUN
bjp-23604	184	22	coli	coli	NOUN
bjp-23604	184	23	in	in	ADP
bjp-23604	184	24	an	an	DET
bjp-23604	184	25	in	in	ADP
bjp-23604	184	26	vitro	vitro	X
bjp-23604	184	27	kinetic	kinetic	ADJ
bjp-23604	184	28	model	model	NOUN
bjp-23604	184	29	:	:	PUNCT
bjp-23604	184	30	relation	relation	NOUN
bjp-23604	184	31	between	between	ADP
bjp-23604	184	32	drug	drug	NOUN
bjp-23604	184	33	exposure	exposure	NOUN
bjp-23604	184	34	and	and	CCONJ
bjp-23604	184	35	mutant	mutant	ADJ
bjp-23604	184	36	prevention	prevention	NOUN
bjp-23604	184	37	concentration	concentration	NOUN
bjp-23604	184	38	.	.	PUNCT
bjp-23604	185	1	j	j	PROPN
bjp-23604	185	2	antimicrob	antimicrob	PROPN
bjp-23604	185	3	chemother	chemother	PROPN
bjp-23604	185	4	.	.	PUNCT
bjp-23604	186	1	2006	2006	NUM
bjp-23604	186	2	;	;	PUNCT
bjp-23604	186	3	57	57	NUM
bjp-23604	186	4	:	:	SYM
bjp-23604	186	5	1116	1116	NUM
bjp-23604	186	6	-	-	SYM
bjp-23604	186	7	21	21	NUM
bjp-23604	186	8	.	.	PUNCT
bjp-23604	187	1	navarro	navarro	PROPN
bjp-23604	187	2	sm	sm	PROPN
bjp-23604	187	3	,	,	PUNCT
bjp-23604	187	4	coloma	coloma	PROPN
bjp-23604	187	5	milano	milano	PROPN
bjp-23604	187	6	c	c	PROPN
bjp-23604	187	7	,	,	PUNCT
bjp-23604	187	8	zarzuelo	zarzuelo	NOUN
bjp-23604	187	9	castañeda	castañeda	PROPN
bjp-23604	187	10	a	a	PRON
bjp-23604	187	11	,	,	PUNCT
bjp-23604	187	12	sayalero	sayalero	PROPN
bjp-23604	187	13	marinero	marinero	PROPN
bjp-23604	187	14	ml	ml	NOUN
bjp-23604	187	15	,	,	PUNCT
bjp-23604	187	16	sánchez	sánchez	PROPN
bjp-23604	187	17	-	-	PUNCT
bjp-23604	187	18	navarro	navarro	PROPN
bjp-23604	187	19	a.	a.	NOUN
bjp-23604	187	20	pharmacokinetics	pharmacokinetic	NOUN
bjp-23604	187	21	of	of	ADP
bjp-23604	187	22	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	187	23	as	as	ADP
bjp-23604	187	24	a	a	DET
bjp-23604	187	25	tool	tool	NOUN
bjp-23604	187	26	to	to	PART
bjp-23604	187	27	optimise	optimise	VERB
bjp-23604	187	28	dosage	dosage	NOUN
bjp-23604	187	29	schedules	schedule	NOUN
bjp-23604	187	30	in	in	ADP
bjp-23604	187	31	community	community	NOUN
bjp-23604	187	32	patients	patient	NOUN
bjp-23604	187	33	.	.	PUNCT
bjp-23604	188	1	clin	clin	PROPN
bjp-23604	188	2	pharmacokinet	pharmacokinet	PROPN
bjp-23604	188	3	.	.	PUNCT
bjp-23604	189	1	2002a	2002a	NOUN
bjp-23604	189	2	;	;	PUNCT
bjp-23604	189	3	41	41	NUM
bjp-23604	189	4	:	:	PUNCT
bjp-23604	189	5	1213–20	1213–20	NUM
bjp-23604	189	6	.	.	PUNCT
bjp-23604	190	1	navarro	navarro	PROPN
bjp-23604	190	2	sm	sm	PROPN
bjp-23604	190	3	,	,	PUNCT
bjp-23604	190	4	sayalero	sayalero	VERB
bjp-23604	190	5	marinero	marinero	PROPN
bjp-23604	190	6	m	m	PROPN
bjp-23604	190	7	,	,	PUNCT
bjp-23604	190	8	sánchez	sánchez	PROPN
bjp-23604	190	9	navarro	navarro	PROPN
bjp-23604	190	10	a.	a.	NOUN
bjp-23604	190	11	pharmacokinetic	pharmacokinetic	PROPN
bjp-23604	190	12	/	/	SYM
bjp-23604	190	13	pharmacodynamic	pharmacodynamic	ADJ
bjp-23604	190	14	modeling	modeling	NOUN
bjp-23604	190	15	of	of	ADP
bjp-23604	190	16	ciprofloxacin	ciprofloxacin	PROPN
bjp-23604	190	17	250	250	NUM
bjp-23604	190	18	mg/12	mg/12	PROPN
bjp-23604	190	19	h	h	NOUN
bjp-23604	190	20	versus	versus	ADP
bjp-23604	190	21	500	500	NUM
bjp-23604	190	22	mg/24	mg/24	PROPN
bjp-23604	190	23	h	h	NOUN
bjp-23604	190	24	for	for	ADP
bjp-23604	190	25	urinary	urinary	ADJ
bjp-23604	190	26	infections	infection	NOUN
bjp-23604	190	27	.	.	PUNCT
bjp-23604	191	1	j	j	PROPN
bjp-23604	191	2	antimicrob	antimicrob	PROPN
bjp-23604	191	3	chemother	chemother	PROPN
bjp-23604	191	4	.	.	PUNCT
bjp-23604	192	1	2002b	2002b	NUM
bjp-23604	192	2	;	;	PUNCT
bjp-23604	192	3	50	50	NUM
bjp-23604	192	4	:	:	SYM
bjp-23604	192	5	67	67	NUM
bjp-23604	192	6	-	-	SYM
bjp-23604	192	7	72	72	NUM
bjp-23604	192	8	.	.	PUNCT
bjp-23604	193	1	scaglione	scaglione	NOUN
bjp-23604	193	2	f	f	PROPN
bjp-23604	193	3	,	,	PUNCT
bjp-23604	193	4	mouton	mouton	PROPN
bjp-23604	193	5	j	j	PROPN
bjp-23604	193	6	,	,	PUNCT
bjp-23604	193	7	mattina	mattina	PROPN
bjp-23604	193	8	r	r	PROPN
bjp-23604	193	9	,	,	PUNCT
bjp-23604	193	10	fraschini	fraschini	NOUN
bjp-23604	193	11	f	f	X
bjp-23604	193	12	:	:	PUNCT
bjp-23604	193	13	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	193	14	of	of	ADP
bjp-23604	193	15	levofloxacin	levofloxacin	NOUN
bjp-23604	193	16	and	and	CCONJ
bjp-23604	193	17	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	193	18	in	in	ADP
bjp-23604	193	19	a	a	DET
bjp-23604	193	20	murine	murine	ADJ
bjp-23604	193	21	pneumonia	pneumonia	NOUN
bjp-23604	193	22	model	model	NOUN
bjp-23604	193	23	:	:	PUNCT
bjp-23604	193	24	peak	peak	NOUN
bjp-23604	193	25	concentration	concentration	NOUN
bjp-23604	193	26	/	/	SYM
bjp-23604	193	27	mic	mic	NOUN
bjp-23604	193	28	versus	versus	ADP
bjp-23604	193	29	area	area	NOUN
bjp-23604	193	30	under	under	ADP
bjp-23604	193	31	the	the	DET
bjp-23604	193	32	curve	curve	NOUN
bjp-23604	193	33	/	/	SYM
bjp-23604	193	34	mic	mic	ADJ
bjp-23604	193	35	ratios	ratio	NOUN
bjp-23604	193	36	.	.	PUNCT
bjp-23604	194	1	antimicrob	antimicrob	PROPN
bjp-23604	194	2	agents	agents	PROPN
bjp-23604	194	3	chemother	chemother	PROPN
bjp-23604	194	4	.	.	PUNCT
bjp-23604	195	1	2003	2003	NUM
bjp-23604	195	2	;	;	PUNCT
bjp-23604	195	3	47	47	NUM
bjp-23604	195	4	:	:	SYM
bjp-23604	195	5	2749	2749	NUM
bjp-23604	195	6	-	-	SYM
bjp-23604	195	7	55	55	NUM
bjp-23604	195	8	.	.	PUNCT
bjp-23604	196	1	schentag	schentag	ADJ
bjp-23604	196	2	j.	j.	PROPN
bjp-23604	196	3	clinical	clinical	PROPN
bjp-23604	196	4	pharmacology	pharmacology	NOUN
bjp-23604	196	5	of	of	ADP
bjp-23604	196	6	the	the	DET
bjp-23604	196	7	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	196	8	:	:	PUNCT
bjp-23604	196	9	studies	study	NOUN
bjp-23604	196	10	in	in	ADP
bjp-23604	196	11	human	human	ADJ
bjp-23604	196	12	dynamic	dynamic	ADJ
bjp-23604	196	13	/	/	SYM
bjp-23604	196	14	kinetic	kinetic	NOUN
bjp-23604	196	15	models	model	NOUN
bjp-23604	196	16	.	.	PUNCT
bjp-23604	197	1	clin	clin	PROPN
bjp-23604	197	2	infect	infect	PROPN
bjp-23604	197	3	dis	dis	PROPN
bjp-23604	197	4	.	.	PROPN
bjp-23604	198	1	2000	2000	NUM
bjp-23604	198	2	;	;	PUNCT
bjp-23604	198	3	31(suppl	31(suppl	NUM
bjp-23604	198	4	2	2	NUM
bjp-23604	198	5	):	):	PUNCT
bjp-23604	198	6	40	40	NUM
bjp-23604	198	7	-	-	SYM
bjp-23604	198	8	44	44	NUM
bjp-23604	198	9	.	.	PUNCT
bjp-23604	199	1	spangler	spangler	PROPN
bjp-23604	199	2	sk	sk	PROPN
bjp-23604	199	3	,	,	PUNCT
bjp-23604	199	4	lin	lin	PROPN
bjp-23604	199	5	g	g	PROPN
bjp-23604	199	6	,	,	PUNCT
bjp-23604	199	7	jacobs	jacobs	PROPN
bjp-23604	199	8	mr	mr	PROPN
bjp-23604	199	9	,	,	PUNCT
bjp-23604	199	10	appelbaum	appelbaum	PROPN
bjp-23604	199	11	pc	pc	NOUN
bjp-23604	199	12	.	.	PUNCT
bjp-23604	200	1	postantibiotic	postantibiotic	ADJ
bjp-23604	200	2	effect	effect	NOUN
bjp-23604	200	3	and	and	CCONJ
bjp-23604	200	4	postantibiotic	postantibiotic	ADJ
bjp-23604	200	5	sub	sub	ADJ
bjp-23604	200	6	-	-	ADJ
bjp-23604	200	7	mic	mic	ADJ
bjp-23604	200	8	effect	effect	NOUN
bjp-23604	200	9	of	of	ADP
bjp-23604	200	10	levofloxacin	levofloxacin	NOUN
bjp-23604	200	11	compared	compare	VERB
bjp-23604	200	12	to	to	ADP
bjp-23604	200	13	those	those	PRON
bjp-23604	200	14	of	of	ADP
bjp-23604	200	15	ofloxacin	ofloxacin	PROPN
bjp-23604	200	16	,	,	PUNCT
bjp-23604	200	17	ciprofloxacin	ciprofloxacin	NOUN
bjp-23604	200	18	,	,	PUNCT
bjp-23604	200	19	erythromycin	erythromycin	NOUN
bjp-23604	200	20	,	,	PUNCT
bjp-23604	200	21	azithromycin	azithromycin	PROPN
bjp-23604	200	22	,	,	PUNCT
bjp-23604	200	23	and	and	CCONJ
bjp-23604	200	24	clarithromycin	clarithromycin	VERB
bjp-23604	200	25	against	against	ADP
bjp-23604	200	26	20	20	NUM
bjp-23604	200	27	pneumococci	pneumococci	NOUN
bjp-23604	200	28	.	.	PUNCT
bjp-23604	201	1	antimicrob	antimicrob	PROPN
bjp-23604	201	2	agents	agents	PROPN
bjp-23604	201	3	chemother	chemother	PROPN
bjp-23604	201	4	.	.	PUNCT
bjp-23604	202	1	1998	1998	NUM
bjp-23604	202	2	;	;	PUNCT
bjp-23604	202	3	42	42	NUM
bjp-23604	202	4	:	:	SYM
bjp-23604	202	5	1253	1253	NUM
bjp-23604	202	6	.	.	PUNCT
bjp-23604	203	1	van	van	PROPN
bjp-23604	203	2	bambeke	bambeke	PROPN
bjp-23604	203	3	f	f	PROPN
bjp-23604	203	4	,	,	PUNCT
bjp-23604	203	5	michot	michot	VERB
bjp-23604	203	6	j	j	PROPN
bjp-23604	203	7	,	,	PUNCT
bjp-23604	203	8	van	van	PROPN
bjp-23604	203	9	eldere	eldere	PROPN
bjp-23604	203	10	j	j	PROPN
bjp-23604	203	11	,	,	PUNCT
bjp-23604	203	12	tulkens	tulkens	PROPN
bjp-23604	203	13	p.	p.	NOUN
bjp-23604	203	14	quinolones	quinolone	NOUN
bjp-23604	203	15	in	in	ADP
bjp-23604	203	16	2005	2005	NUM
bjp-23604	203	17	:	:	PUNCT
bjp-23604	203	18	an	an	DET
bjp-23604	203	19	update	update	NOUN
bjp-23604	203	20	.	.	PUNCT
bjp-23604	204	1	clin	clin	PROPN
bjp-23604	204	2	microbiol	microbiol	PROPN
bjp-23604	204	3	infect	infect	PROPN
bjp-23604	204	4	.	.	PUNCT
bjp-23604	205	1	2005	2005	NUM
bjp-23604	205	2	;	;	PUNCT
bjp-23604	205	3	11	11	NUM
bjp-23604	205	4	:	:	SYM
bjp-23604	205	5	256	256	NUM
bjp-23604	205	6	-	-	SYM
bjp-23604	205	7	80	80	NUM
bjp-23604	205	8	.	.	PUNCT
bjp-23604	206	1	wispelwey	wispelwey	PROPN
bjp-23604	206	2	b.	b.	PROPN
bjp-23604	206	3	clinical	clinical	ADJ
bjp-23604	206	4	implications	implication	NOUN
bjp-23604	206	5	of	of	ADP
bjp-23604	206	6	pharmacokinetics	pharmacokinetic	NOUN
bjp-23604	206	7	and	and	CCONJ
bjp-23604	206	8	pharmacodynamics	pharmacodynamic	NOUN
bjp-23604	206	9	of	of	ADP
bjp-23604	206	10	fluoroquinolones	fluoroquinolone	NOUN
bjp-23604	206	11	.	.	PUNCT
bjp-23604	207	1	clin	clin	PROPN
bjp-23604	207	2	infect	infect	PROPN
bjp-23604	207	3	dis	dis	PROPN
bjp-23604	207	4	.	.	PUNCT
bjp-23604	208	1	2005	2005	NUM
bjp-23604	208	2	;	;	PUNCT
bjp-23604	208	3	41(suppl	41(suppl	NUM
bjp-23604	208	4	2	2	NUM
bjp-23604	208	5	):	):	PUNCT
bjp-23604	208	6	127	127	NUM
bjp-23604	208	7	-	-	SYM
bjp-23604	208	8	35	35	NUM
bjp-23604	208	9	.	.	PUNCT
bjp-23604	209	1	zelenitsky	zelenitsky	PROPN
bjp-23604	209	2	s	s	PROPN
bjp-23604	209	3	,	,	PUNCT
bjp-23604	209	4	ariano	ariano	ADJ
bjp-23604	209	5	r	r	NOUN
bjp-23604	209	6	,	,	PUNCT
bjp-23604	209	7	iacovides	iacovide	VERB
bjp-23604	209	8	h	h	NOUN
bjp-23604	209	9	,	,	PUNCT
bjp-23604	209	10	sun	sun	PROPN
bjp-23604	209	11	s	s	PROPN
bjp-23604	209	12	,	,	PUNCT
bjp-23604	210	1	harding	harding	PROPN
bjp-23604	210	2	g.	g.	PROPN
bjp-23604	210	3	auc(0t)/mic	auc(0t)/mic	PROPN
bjp-23604	210	4	is	be	AUX
bjp-23604	210	5	a	a	DET
bjp-23604	210	6	continuous	continuous	ADJ
bjp-23604	210	7	index	index	NOUN
bjp-23604	210	8	of	of	ADP
bjp-23604	210	9	fluoroquinolone	fluoroquinolone	NOUN
bjp-23604	210	10	exposure	exposure	NOUN
bjp-23604	210	11	and	and	CCONJ
bjp-23604	210	12	predictive	predictive	NOUN
bjp-23604	210	13	of	of	ADP
bjp-23604	210	14	antibacterial	antibacterial	ADJ
bjp-23604	210	15	response	response	NOUN
bjp-23604	210	16	for	for	ADP
bjp-23604	210	17	streptococcus	streptococcus	NOUN
bjp-23604	210	18	pneumoniae	pneumoniae	ADJ
bjp-23604	210	19	in	in	ADP
bjp-23604	210	20	an	an	DET
bjp-23604	210	21	in	in	ADP
bjp-23604	210	22	vitro	vitro	X
bjp-23604	210	23	infection	infection	NOUN
bjp-23604	210	24	model	model	NOUN
bjp-23604	210	25	.	.	PUNCT
bjp-23604	211	1	j	j	PROPN
bjp-23604	211	2	antimicrob	antimicrob	PROPN
bjp-23604	211	3	chemother	chemother	PROPN
bjp-23604	211	4	.	.	PUNCT
bjp-23604	212	1	2003	2003	NUM
bjp-23604	212	2	;	;	PUNCT
bjp-23604	212	3	51	51	NUM
bjp-23604	212	4	:	:	PUNCT
bjp-23604	212	5	905	905	NUM
bjp-23604	212	6	-	-	SYM
bjp-23604	212	7	11	11	NUM
bjp-23604	212	8	.	.	PUNCT
bjp-23604	213	1	626	626	NUM
bjp-23604	213	2	bangladesh	bangladesh	NOUN
bjp-23604	213	3	j	j	PROPN
bjp-23604	213	4	pharmacol	pharmacol	PROPN
bjp-23604	213	5	2015	2015	NUM
bjp-23604	213	6	;	;	PUNCT
bjp-23604	213	7	10	10	NUM
bjp-23604	213	8	:	:	SYM
bjp-23604	213	9	621	621	NUM
bjp-23604	213	10	-	-	SYM
bjp-23604	213	11	626	626	NUM
bjp-23604	213	12	mailto:aanaa_tomas@yahoo.com	mailto:aanaa_tomas@yahoo.com	NOUN
bjp-23604	213	13	introduction	introduction	NOUN
bjp-23604	213	14	:	:	PUNCT
bjp-23604	213	15	materials	material	NOUN
bjp-23604	213	16	and	and	CCONJ
bjp-23604	213	17	methods	method	NOUN
bjp-23604	213	18	:	:	PUNCT
bjp-23604	213	19	results	result	NOUN
bjp-23604	213	20	:	:	PUNCT
bjp-23604	213	21	table	table	VERB
bjp-23604	213	22	i	i	PRON
bjp-23604	213	23	:	:	PUNCT
bjp-23604	213	24	table	table	PROPN
bjp-23604	213	25	ii	ii	PROPN
bjp-23604	213	26	:	:	PUNCT
bjp-23604	213	27	discussion	discussion	NOUN
bjp-23604	213	28	:	:	PUNCT
bjp-23604	213	29	conclusion	conclusion	NOUN
bjp-23604	213	30	:	:	PUNCT
bjp-23604	213	31	acknowledgement	acknowledgement	NOUN
bjp-23604	213	32	:	:	PUNCT
bjp-23604	213	33	references	reference	NOUN
bjp-23604	213	34	:	:	PUNCT
bjp-23604	213	35	author	author	NOUN
bjp-23604	213	36	info	info	PROPN
bjp-23604	213	37	ana	ana	PROPN
bjp-23604	213	38	tomas	tomas	PROPN
bjp-23604	213	39	principal	principal	ADJ
bjp-23604	213	40	contact	contact	NOUN
bjp-23604	213	41	email	email	NOUN
bjp-23604	213	42	aanaatomasyahoocom	aanaatomasyahoocom	PROPN
bjp-23604	214	1	tel	tel	ADP
bjp-23604	214	2	38121522172	38121522172	NUM
bjp-23604	214	3	:	:	PUNCT
bjp-23604	215	1	dateprinted	dateprinte	VERB
bjp-23604	215	2	:	:	PUNCT
bjp-23604	215	3	this	this	DET
bjp-23604	215	4	article	article	NOUN
bjp-23604	215	5	was	be	AUX
bjp-23604	215	6	downloaded	download	VERB
bjp-23604	215	7	by	by	ADP
bjp-23604	215	8	you	you	PRON
bjp-23604	215	9	on	on	ADP
bjp-23604	215	10	:	:	PUNCT
bjp-23604	215	11	aug	aug	PROPN
bjp-23604	215	12	25	25	NUM
bjp-23604	215	13	,	,	PUNCT
bjp-23604	215	14	2016	2016	NUM