id	sid	tid	token	lemma	pos
bjp-33625	1	1	bangladesh	bangladesh	PROPN
bjp-33625	1	2	journal	journal	PROPN
bjp-33625	1	3	of	of	ADP
bjp-33625	1	4	pharmacology	pharmacology	NOUN
bjp-33625	1	5	research	research	NOUN
bjp-33625	1	6	article	article	NOUN
bjp-33625	1	7	pass	pass	VERB
bjp-33625	1	8	and	and	CCONJ
bjp-33625	1	9	swiss	swiss	ADJ
bjp-33625	1	10	adme	adme	NOUN
bjp-33625	1	11	collaborated	collaborate	VERB
bjp-33625	1	12	in	in	ADP
bjp-33625	1	13	silico	silico	NOUN
bjp-33625	1	14	docking	dock	VERB
bjp-33625	1	15	approach	approach	NOUN
bjp-33625	1	16	to	to	ADP
bjp-33625	1	17	the	the	DET
bjp-33625	1	18	synthesis	synthesis	NOUN
bjp-33625	1	19	of	of	ADP
bjp-33625	1	20	certain	certain	ADJ
bjp-33625	1	21	pyrazoline	pyrazoline	NOUN
bjp-33625	1	22	spacer	spacer	NOUN
bjp-33625	1	23	compounds	compound	NOUN
bjp-33625	1	24	for	for	ADP
bjp-33625	1	25	dihydrofolate	dihydrofolate	NOUN
bjp-33625	1	26	reductase	reductase	NOUN
bjp-33625	1	27	inhibition	inhibition	NOUN
bjp-33625	1	28	and	and	CCONJ
bjp-33625	1	29	antimalarial	antimalarial	ADJ
bjp-33625	1	30	activity	activity	NOUN
bjp-33625	1	31	bjp	bjp	NOUN
bjp-33625	1	32	introduction	introduction	NOUN
bjp-33625	1	33	the	the	DET
bjp-33625	1	34	rule	rule	NOUN
bjp-33625	1	35	of	of	ADP
bjp-33625	1	36	drug	drug	NOUN
bjp-33625	1	37	design	design	NOUN
bjp-33625	1	38	is	be	AUX
bjp-33625	1	39	more	more	ADV
bjp-33625	1	40	focused	focused	ADJ
bjp-33625	1	41	into	into	ADP
bjp-33625	1	42	a	a	DET
bjp-33625	1	43	receptor	receptor	NOUN
bjp-33625	1	44	based	base	VERB
bjp-33625	1	45	design	design	NOUN
bjp-33625	1	46	.	.	PUNCT
bjp-33625	2	1	the	the	DET
bjp-33625	2	2	structure	structure	NOUN
bjp-33625	2	3	of	of	ADP
bjp-33625	2	4	the	the	DET
bjp-33625	2	5	target	target	NOUN
bjp-33625	2	6	is	be	AUX
bjp-33625	2	7	usually	usually	ADV
bjp-33625	2	8	known	know	VERB
bjp-33625	2	9	to	to	ADP
bjp-33625	2	10	high	high	ADJ
bjp-33625	2	11	resolution	resolution	NOUN
bjp-33625	2	12	and	and	CCONJ
bjp-33625	2	13	the	the	DET
bjp-33625	2	14	binding	bind	VERB
bjp-33625	2	15	site	site	NOUN
bjp-33625	2	16	is	be	AUX
bjp-33625	2	17	well	well	ADV
bjp-33625	2	18	defined	define	VERB
bjp-33625	2	19	.	.	PUNCT
bjp-33625	3	1	binding	bind	VERB
bjp-33625	3	2	of	of	ADP
bjp-33625	3	3	the	the	DET
bjp-33625	3	4	drug	drug	NOUN
bjp-33625	3	5	to	to	ADP
bjp-33625	3	6	these	these	DET
bjp-33625	3	7	hypothetical	hypothetical	ADJ
bjp-33625	3	8	interaction	interaction	NOUN
bjp-33625	3	9	sites	site	NOUN
bjp-33625	3	10	is	be	AUX
bjp-33625	3	11	further	far	ADV
bjp-33625	3	12	influenced	influence	VERB
bjp-33625	3	13	by	by	ADP
bjp-33625	3	14	hydrogen	hydrogen	NOUN
bjp-33625	3	15	bonds	bond	NOUN
bjp-33625	3	16	,	,	PUNCT
bjp-33625	3	17	electrostatic	electrostatic	ADJ
bjp-33625	3	18	and	and	CCONJ
bjp-33625	3	19	other	other	ADJ
bjp-33625	3	20	non	non	ADJ
bjp-33625	3	21	-	-	ADJ
bjp-33625	3	22	covalent	covalent	ADJ
bjp-33625	3	23	interactions	interaction	NOUN
bjp-33625	3	24	(	(	PUNCT
bjp-33625	3	25	wade	wade	NOUN
bjp-33625	3	26	and	and	CCONJ
bjp-33625	3	27	goodford	goodford	NOUN
bjp-33625	3	28	,	,	PUNCT
bjp-33625	3	29	1989	1989	NUM
bjp-33625	3	30	)	)	PUNCT
bjp-33625	3	31	.	.	PUNCT
bjp-33625	4	1	the	the	DET
bjp-33625	4	2	utilization	utilization	NOUN
bjp-33625	4	3	of	of	ADP
bjp-33625	4	4	molecular	molecular	ADJ
bjp-33625	4	5	docking	docking	NOUN
bjp-33625	4	6	studies	study	NOUN
bjp-33625	4	7	made	make	VERB
bjp-33625	4	8	its	its	PRON
bjp-33625	4	9	intervention	intervention	NOUN
bjp-33625	4	10	at	at	ADP
bjp-33625	4	11	this	this	DET
bjp-33625	4	12	point	point	NOUN
bjp-33625	4	13	of	of	ADP
bjp-33625	4	14	drug	drug	NOUN
bjp-33625	4	15	synthesis	synthesis	NOUN
bjp-33625	4	16	.	.	PUNCT
bjp-33625	5	1	here	here	ADV
bjp-33625	5	2	comes	come	VERB
bjp-33625	5	3	the	the	DET
bjp-33625	5	4	scope	scope	NOUN
bjp-33625	5	5	of	of	ADP
bjp-33625	5	6	utilization	utilization	NOUN
bjp-33625	5	7	of	of	ADP
bjp-33625	5	8	other	other	ADJ
bjp-33625	5	9	web	web	NOUN
bjp-33625	5	10	based	base	VERB
bjp-33625	5	11	in	in	ADP
bjp-33625	5	12	silico	silico	NOUN
bjp-33625	5	13	screening	screen	VERB
bjp-33625	5	14	as	as	ADP
bjp-33625	5	15	a	a	DET
bjp-33625	5	16	method	method	NOUN
bjp-33625	5	17	of	of	ADP
bjp-33625	5	18	the	the	DET
bjp-33625	5	19	multilevel	multilevel	ADJ
bjp-33625	5	20	screening	screening	NOUN
bjp-33625	5	21	process	process	NOUN
bjp-33625	5	22	.	.	PUNCT
bjp-33625	6	1	the	the	DET
bjp-33625	6	2	results	result	NOUN
bjp-33625	6	3	obtained	obtain	VERB
bjp-33625	6	4	from	from	ADP
bjp-33625	6	5	molinspiration	molinspiration	NOUN
bjp-33625	6	6	and	and	CCONJ
bjp-33625	6	7	checking	check	VERB
bjp-33625	6	8	for	for	ADP
bjp-33625	6	9	its	its	PRON
bjp-33625	6	10	match	match	NOUN
bjp-33625	6	11	on	on	ADP
bjp-33625	6	12	the	the	DET
bjp-33625	6	13	principles	principle	NOUN
bjp-33625	6	14	of	of	ADP
bjp-33625	6	15	lipinski	lipinski	PROPN
bjp-33625	6	16	rule	rule	NOUN
bjp-33625	6	17	are	be	AUX
bjp-33625	6	18	the	the	DET
bjp-33625	6	19	one	one	NUM
bjp-33625	6	20	of	of	ADP
bjp-33625	6	21	first	first	ADV
bjp-33625	6	22	evolved	evolve	VERB
bjp-33625	6	23	of	of	ADP
bjp-33625	6	24	this	this	DET
bjp-33625	6	25	kind	kind	NOUN
bjp-33625	6	26	(	(	PUNCT
bjp-33625	6	27	mabkhot	mabkhot	NOUN
bjp-33625	6	28	et	et	PROPN
bjp-33625	6	29	al	al	PROPN
bjp-33625	6	30	.	.	PROPN
bjp-33625	6	31	,	,	PUNCT
bjp-33625	6	32	2014	2014	NUM
bjp-33625	6	33	)	)	PUNCT
bjp-33625	6	34	used	use	VERB
bjp-33625	6	35	as	as	ADP
bjp-33625	6	36	the	the	DET
bjp-33625	6	37	choice	choice	NOUN
bjp-33625	6	38	of	of	ADP
bjp-33625	6	39	present	present	ADJ
bjp-33625	6	40	study	study	NOUN
bjp-33625	6	41	.	.	PUNCT
bjp-33625	7	1	the	the	DET
bjp-33625	7	2	resulted	resulted	ADJ
bjp-33625	7	3	compounds	compound	NOUN
bjp-33625	7	4	were	be	AUX
bjp-33625	7	5	a	a	DET
bjp-33625	7	6	fusion	fusion	NOUN
bjp-33625	7	7	of	of	ADP
bjp-33625	7	8	two	two	NUM
bjp-33625	7	9	major	major	ADJ
bjp-33625	7	10	heterocyclic	heterocyclic	ADJ
bjp-33625	7	11	entities	entity	NOUN
bjp-33625	7	12	benzimidazole	benzimidazole	NOUN
bjp-33625	7	13	and	and	CCONJ
bjp-33625	7	14	imidazole	imidazole	NOUN
bjp-33625	7	15	connected	connect	VERB
bjp-33625	7	16	with	with	ADP
bjp-33625	7	17	a	a	DET
bjp-33625	7	18	pyrazoline	pyrazoline	NOUN
bjp-33625	7	19	spacer	spacer	NOUN
bjp-33625	7	20	.	.	PUNCT
bjp-33625	8	1	the	the	DET
bjp-33625	8	2	nitrogen	nitrogen	NOUN
bjp-33625	8	3	heterocycles	heterocycle	NOUN
bjp-33625	8	4	are	be	AUX
bjp-33625	8	5	well	well	ADV
bjp-33625	8	6	-	-	PUNCT
bjp-33625	8	7	known	know	VERB
bjp-33625	8	8	about	about	ADP
bjp-33625	8	9	their	their	PRON
bjp-33625	8	10	ability	ability	NOUN
bjp-33625	8	11	to	to	PART
bjp-33625	8	12	participate	participate	VERB
bjp-33625	8	13	in	in	ADP
bjp-33625	8	14	the	the	DET
bjp-33625	8	15	diverse	diverse	ADJ
bjp-33625	8	16	biological	biological	ADJ
bjp-33625	8	17	activities	activity	NOUN
bjp-33625	8	18	(	(	PUNCT
bjp-33625	8	19	akhtar	akhtar	PROPN
bjp-33625	8	20	et	et	PROPN
bjp-33625	8	21	al	al	PROPN
bjp-33625	8	22	.	.	PROPN
bjp-33625	8	23	,	,	PUNCT
bjp-33625	8	24	2017	2017	NUM
bjp-33625	8	25	)	)	PUNCT
bjp-33625	8	26	.	.	PUNCT
bjp-33625	9	1	considerable	considerable	ADJ
bjp-33625	9	2	attention	attention	NOUN
bjp-33625	9	3	was	be	AUX
bjp-33625	9	4	given	give	VERB
bjp-33625	9	5	here	here	ADV
bjp-33625	9	6	on	on	ADP
bjp-33625	9	7	the	the	DET
bjp-33625	9	8	synthesizing	synthesize	VERB
bjp-33625	9	9	molecules	molecule	NOUN
bjp-33625	9	10	,	,	PUNCT
bjp-33625	9	11	which	which	PRON
bjp-33625	9	12	have	have	VERB
bjp-33625	9	13	three	three	NUM
bjp-33625	9	14	nitrogen	nitrogen	NOUN
bjp-33625	9	15	heterocyclic	heterocyclic	ADJ
bjp-33625	9	16	rings	ring	NOUN
bjp-33625	9	17	.	.	PUNCT
bjp-33625	10	1	chalcones	chalcone	NOUN
bjp-33625	10	2	required	require	VERB
bjp-33625	10	3	for	for	ADP
bjp-33625	10	4	synthesis	synthesis	NOUN
bjp-33625	10	5	were	be	AUX
bjp-33625	10	6	prepared	prepare	VERB
bjp-33625	10	7	from	from	ADP
bjp-33625	10	8	benzimidazole	benzimidazole	NOUN
bjp-33625	10	9	and	and	CCONJ
bjp-33625	10	10	aromatic	aromatic	ADJ
bjp-33625	10	11	aldehydes	aldehyde	NOUN
bjp-33625	10	12	.	.	PUNCT
bjp-33625	11	1	the	the	DET
bjp-33625	11	2	acid	acid	PROPN
bjp-33625	11	3	hydrazide	hydrazide	NOUN
bjp-33625	11	4	was	be	AUX
bjp-33625	11	5	prepared	prepare	VERB
bjp-33625	11	6	from	from	ADP
bjp-33625	11	7	imidazole	imidazole	NOUN
bjp-33625	11	8	.	.	PUNCT
bjp-33625	12	1	the	the	DET
bjp-33625	12	2	pictorial	pictorial	ADJ
bjp-33625	12	3	representation	representation	NOUN
bjp-33625	12	4	of	of	ADP
bjp-33625	12	5	this	this	DET
bjp-33625	12	6	heterocyclic	heterocyclic	ADJ
bjp-33625	12	7	combination	combination	NOUN
bjp-33625	12	8	,	,	PUNCT
bjp-33625	12	9	spacer	spacer	NOUN
bjp-33625	12	10	and	and	CCONJ
bjp-33625	12	11	the	the	DET
bjp-33625	12	12	way	way	NOUN
bjp-33625	12	13	bulky	bulky	ADJ
bjp-33625	12	14	groups	group	NOUN
bjp-33625	12	15	can	can	AUX
bjp-33625	12	16	be	be	AUX
bjp-33625	12	17	linked	link	VERB
bjp-33625	12	18	(	(	PUNCT
bjp-33625	12	19	figure	figure	NOUN
bjp-33625	12	20	1	1	NUM
bjp-33625	12	21	)	)	PUNCT
bjp-33625	12	22	.	.	PUNCT
bjp-33625	13	1	the	the	DET
bjp-33625	13	2	bulky	bulky	ADJ
bjp-33625	13	3	group	group	NOUN
bjp-33625	13	4	with	with	ADP
bjp-33625	13	5	substitutions	substitution	NOUN
bjp-33625	13	6	is	be	AUX
bjp-33625	13	7	planned	plan	VERB
bjp-33625	13	8	on	on	ADP
bjp-33625	13	9	this	this	DET
bjp-33625	13	10	pyrazoline	pyrazoline	NOUN
bjp-33625	13	11	spacer	spacer	NOUN
bjp-33625	13	12	in	in	ADP
bjp-33625	13	13	an	an	DET
bjp-33625	13	14	intention	intention	NOUN
bjp-33625	13	15	of	of	ADP
bjp-33625	13	16	studying	study	VERB
bjp-33625	13	17	a	a	DET
bjp-33625	13	18	journal	journal	NOUN
bjp-33625	13	19	of	of	ADP
bjp-33625	13	20	the	the	DET
bjp-33625	13	21	bangladesh	bangladesh	NOUN
bjp-33625	13	22	pharmacological	pharmacological	ADJ
bjp-33625	13	23	society	society	NOUN
bjp-33625	13	24	(	(	PUNCT
bjp-33625	13	25	bdps	bdps	NOUN
bjp-33625	13	26	)	)	PUNCT
bjp-33625	13	27	bangladesh	bangladesh	PROPN
bjp-33625	13	28	j	j	PROPN
bjp-33625	13	29	pharmacol	pharmacol	PROPN
bjp-33625	13	30	2018	2018	NUM
bjp-33625	13	31	;	;	PUNCT
bjp-33625	13	32	13	13	NUM
bjp-33625	13	33	:	:	SYM
bjp-33625	13	34	23	23	NUM
bjp-33625	13	35	-	-	SYM
bjp-33625	13	36	29	29	NUM
bjp-33625	13	37	journal	journal	NOUN
bjp-33625	13	38	homepage	homepage	NOUN
bjp-33625	13	39	:	:	PUNCT
bjp-33625	13	40	www.banglajol.info	www.banglajol.info	PROPN
bjp-33625	13	41	abstracted	abstract	VERB
bjp-33625	13	42	/	/	SYM
bjp-33625	13	43	indexed	index	VERB
bjp-33625	13	44	in	in	ADP
bjp-33625	13	45	academic	academic	ADJ
bjp-33625	13	46	search	search	NOUN
bjp-33625	13	47	complete	complete	ADJ
bjp-33625	13	48	,	,	PUNCT
bjp-33625	13	49	asia	asia	PROPN
bjp-33625	13	50	journals	journal	NOUN
bjp-33625	13	51	online	online	ADV
bjp-33625	13	52	,	,	PUNCT
bjp-33625	13	53	bangladesh	bangladesh	NOUN
bjp-33625	13	54	journals	journal	NOUN
bjp-33625	13	55	online	online	ADV
bjp-33625	13	56	,	,	PUNCT
bjp-33625	13	57	biological	biological	ADJ
bjp-33625	13	58	abstracts	abstract	NOUN
bjp-33625	13	59	,	,	PUNCT
bjp-33625	13	60	biosis	biosis	NOUN
bjp-33625	13	61	previews	preview	NOUN
bjp-33625	13	62	,	,	PUNCT
bjp-33625	13	63	cab	cab	NOUN
bjp-33625	13	64	abstracts	abstract	NOUN
bjp-33625	13	65	,	,	PUNCT
bjp-33625	13	66	current	current	ADJ
bjp-33625	13	67	abstracts	abstract	NOUN
bjp-33625	13	68	,	,	PUNCT
bjp-33625	13	69	directory	directory	NOUN
bjp-33625	13	70	of	of	ADP
bjp-33625	13	71	open	open	ADJ
bjp-33625	13	72	access	access	NOUN
bjp-33625	13	73	journals	journal	NOUN
bjp-33625	13	74	,	,	PUNCT
bjp-33625	13	75	embase	embase	NOUN
bjp-33625	13	76	/	/	SYM
bjp-33625	13	77	excerpta	excerpta	NOUN
bjp-33625	13	78	medica	medica	NOUN
bjp-33625	13	79	,	,	PUNCT
bjp-33625	13	80	global	global	ADJ
bjp-33625	13	81	health	health	NOUN
bjp-33625	13	82	,	,	PUNCT
bjp-33625	13	83	google	google	PROPN
bjp-33625	13	84	scholar	scholar	NOUN
bjp-33625	13	85	,	,	PUNCT
bjp-33625	13	86	hinari	hinari	X
bjp-33625	13	87	(	(	PUNCT
bjp-33625	13	88	who	who	PRON
bjp-33625	13	89	)	)	PUNCT
bjp-33625	13	90	,	,	PUNCT
bjp-33625	13	91	international	international	ADJ
bjp-33625	13	92	pharmaceutical	pharmaceutical	ADJ
bjp-33625	13	93	abstracts	abstract	NOUN
bjp-33625	13	94	,	,	PUNCT
bjp-33625	13	95	open	open	ADJ
bjp-33625	13	96	j	j	PROPN
bjp-33625	13	97	-	-	PUNCT
bjp-33625	13	98	gate	gate	NOUN
bjp-33625	13	99	,	,	PUNCT
bjp-33625	13	100	science	science	NOUN
bjp-33625	13	101	citation	citation	NOUN
bjp-33625	13	102	index	index	NOUN
bjp-33625	13	103	expanded	expand	VERB
bjp-33625	13	104	,	,	PUNCT
bjp-33625	13	105	scopus	scopus	NOUN
bjp-33625	13	106	and	and	CCONJ
bjp-33625	13	107	social	social	ADJ
bjp-33625	13	108	sciences	sciences	PROPN
bjp-33625	13	109	citation	citation	NOUN
bjp-33625	13	110	index	index	NOUN
bjp-33625	13	111	;	;	PUNCT
bjp-33625	13	112	issn	issn	PROPN
bjp-33625	13	113	:	:	PUNCT
bjp-33625	13	114	1991	1991	NUM
bjp-33625	13	115	-	-	PUNCT
bjp-33625	13	116	0088	0088	NUM
bjp-33625	13	117	abstract	abstract	ADJ
bjp-33625	13	118	new	new	ADJ
bjp-33625	13	119	series	series	NOUN
bjp-33625	13	120	of	of	ADP
bjp-33625	13	121	pyrazoline	pyrazoline	NOUN
bjp-33625	13	122	spacer	spacer	NOUN
bjp-33625	13	123	compounds	compound	NOUN
bjp-33625	13	124	were	be	AUX
bjp-33625	13	125	prepared	prepare	VERB
bjp-33625	13	126	by	by	ADP
bjp-33625	13	127	the	the	DET
bjp-33625	13	128	reaction	reaction	NOUN
bjp-33625	13	129	between	between	ADP
bjp-33625	13	130	benzimidazole	benzimidazole	PROPN
bjp-33625	13	131	chalcones	chalcone	NOUN
bjp-33625	13	132	and	and	CCONJ
bjp-33625	13	133	(	(	PUNCT
bjp-33625	13	134	2	2	NUM
bjp-33625	13	135	-	-	PUNCT
bjp-33625	13	136	methyl-5	methyl-5	NOUN
bjp-33625	13	137	-	-	PUNCT
bjp-33625	13	138	nitro	nitro	NOUN
bjp-33625	13	139	-	-	PUNCT
bjp-33625	13	140	imidazole-1	imidazole-1	NOUN
bjp-33625	13	141	-	-	ADJ
bjp-33625	13	142	yl)acetic	yl)acetic	ADJ
bjp-33625	13	143	acid	acid	NOUN
bjp-33625	13	144	hydrazide	hydrazide	ADV
bjp-33625	13	145	by	by	ADP
bjp-33625	13	146	the	the	DET
bjp-33625	13	147	sensible	sensible	ADJ
bjp-33625	13	148	use	use	NOUN
bjp-33625	13	149	of	of	ADP
bjp-33625	13	150	michael	michael	PROPN
bjp-33625	13	151	addition	addition	PROPN
bjp-33625	13	152	.	.	PUNCT
bjp-33625	14	1	the	the	DET
bjp-33625	14	2	building	building	NOUN
bjp-33625	14	3	blocks	block	NOUN
bjp-33625	14	4	used	use	VERB
bjp-33625	14	5	for	for	ADP
bjp-33625	14	6	the	the	DET
bjp-33625	14	7	synthesis	synthesis	NOUN
bjp-33625	14	8	of	of	ADP
bjp-33625	14	9	pyrazoline	pyrazoline	NOUN
bjp-33625	14	10	derivatives	derivative	NOUN
bjp-33625	14	11	were	be	AUX
bjp-33625	14	12	opted	opt	VERB
bjp-33625	14	13	by	by	ADP
bjp-33625	14	14	using	use	VERB
bjp-33625	14	15	virtual	virtual	ADJ
bjp-33625	14	16	screening	screening	NOUN
bjp-33625	14	17	by	by	ADP
bjp-33625	14	18	molinspiration	molinspiration	NOUN
bjp-33625	14	19	search	search	NOUN
bjp-33625	14	20	engine	engine	NOUN
bjp-33625	14	21	.	.	PUNCT
bjp-33625	15	1	the	the	DET
bjp-33625	15	2	hypothetically	hypothetically	ADV
bjp-33625	15	3	resulted	result	VERB
bjp-33625	15	4	pyrazoline	pyrazoline	NOUN
bjp-33625	15	5	spacer	spacer	NOUN
bjp-33625	15	6	compounds	compound	NOUN
bjp-33625	15	7	from	from	ADP
bjp-33625	15	8	this	this	DET
bjp-33625	15	9	list	list	NOUN
bjp-33625	15	10	are	be	AUX
bjp-33625	15	11	checked	check	VERB
bjp-33625	15	12	for	for	ADP
bjp-33625	15	13	their	their	PRON
bjp-33625	15	14	reliability	reliability	NOUN
bjp-33625	15	15	on	on	ADP
bjp-33625	15	16	other	other	ADJ
bjp-33625	15	17	in	in	ADP
bjp-33625	15	18	silico	silico	NOUN
bjp-33625	15	19	drug	drug	NOUN
bjp-33625	15	20	designing	design	VERB
bjp-33625	15	21	online	online	ADJ
bjp-33625	15	22	web	web	NOUN
bjp-33625	15	23	services	service	NOUN
bjp-33625	15	24	like	like	ADP
bjp-33625	15	25	pass	pass	VERB
bjp-33625	15	26	online	online	ADJ
bjp-33625	15	27	bioactivity	bioactivity	NOUN
bjp-33625	15	28	,	,	PUNCT
bjp-33625	15	29	swiss	swiss	ADJ
bjp-33625	15	30	adme	adme	NOUN
bjp-33625	15	31	predictor	predictor	NOUN
bjp-33625	15	32	.	.	PUNCT
bjp-33625	16	1	the	the	DET
bjp-33625	16	2	docking	docking	NOUN
bjp-33625	16	3	study	study	NOUN
bjp-33625	16	4	on	on	ADP
bjp-33625	16	5	final	final	ADJ
bjp-33625	16	6	four	four	NUM
bjp-33625	16	7	pyrazoline	pyrazoline	NOUN
bjp-33625	16	8	compounds	compound	NOUN
bjp-33625	16	9	was	be	AUX
bjp-33625	16	10	carried	carry	VERB
bjp-33625	16	11	out	out	ADP
bjp-33625	16	12	using	use	VERB
bjp-33625	16	13	accelrys	accelry	NOUN
bjp-33625	16	14	discovery	discovery	PROPN
bjp-33625	16	15	studio	studio	NOUN
bjp-33625	16	16	3.5	3.5	NUM
bjp-33625	16	17	.	.	PUNCT
bjp-33625	17	1	these	these	DET
bjp-33625	17	2	synthesized	synthesize	VERB
bjp-33625	17	3	compounds	compound	NOUN
bjp-33625	17	4	were	be	AUX
bjp-33625	17	5	,	,	PUNCT
bjp-33625	17	6	later	later	ADV
bjp-33625	17	7	,	,	PUNCT
bjp-33625	17	8	characterized	characterize	VERB
bjp-33625	17	9	with	with	ADP
bjp-33625	17	10	the	the	DET
bjp-33625	17	11	help	help	NOUN
bjp-33625	17	12	of	of	ADP
bjp-33625	17	13	uv	uv	NOUN
bjp-33625	17	14	,	,	PUNCT
bjp-33625	17	15	ir	ir	PROPN
bjp-33625	17	16	,	,	PUNCT
bjp-33625	17	17	mass	mass	PROPN
bjp-33625	17	18	and	and	CCONJ
bjp-33625	17	19	1h	1h	NUM
bjp-33625	17	20	nmr	nmr	NOUN
bjp-33625	17	21	techniques	technique	NOUN
bjp-33625	17	22	.	.	PUNCT
bjp-33625	18	1	these	these	DET
bjp-33625	18	2	compounds	compound	NOUN
bjp-33625	18	3	were	be	AUX
bjp-33625	18	4	further	far	ADV
bjp-33625	18	5	screened	screen	VERB
bjp-33625	18	6	for	for	ADP
bjp-33625	18	7	their	their	PRON
bjp-33625	18	8	in	in	X
bjp-33625	18	9	vitro	vitro	X
bjp-33625	18	10	antimalarial	antimalarial	ADJ
bjp-33625	18	11	effect	effect	NOUN
bjp-33625	18	12	.	.	PUNCT
bjp-33625	19	1	the	the	DET
bjp-33625	19	2	pass	pass	NOUN
bjp-33625	19	3	,	,	PUNCT
bjp-33625	19	4	swiss	swiss	ADJ
bjp-33625	19	5	adme	adme	NOUN
bjp-33625	19	6	assisted	assist	VERB
bjp-33625	19	7	docking	docking	NOUN
bjp-33625	19	8	approach	approach	NOUN
bjp-33625	19	9	and	and	CCONJ
bjp-33625	19	10	the	the	DET
bjp-33625	19	11	use	use	NOUN
bjp-33625	19	12	of	of	ADP
bjp-33625	19	13	combo	combo	ADJ
bjp-33625	19	14	heterocyclic	heterocyclic	ADJ
bjp-33625	19	15	ring	ring	NOUN
bjp-33625	19	16	with	with	ADP
bjp-33625	19	17	pyrazoline	pyrazoline	NOUN
bjp-33625	19	18	scaffold	scaffold	NOUN
bjp-33625	19	19	were	be	AUX
bjp-33625	19	20	found	find	VERB
bjp-33625	19	21	to	to	PART
bjp-33625	19	22	be	be	AUX
bjp-33625	19	23	beneficial	beneficial	ADJ
bjp-33625	19	24	to	to	PART
bjp-33625	19	25	derive	derive	VERB
bjp-33625	19	26	and	and	CCONJ
bjp-33625	19	27	synthesize	synthesize	VERB
bjp-33625	19	28	effective	effective	ADJ
bjp-33625	19	29	antimalarial	antimalarial	ADJ
bjp-33625	19	30	agents	agent	NOUN
bjp-33625	19	31	in	in	ADP
bjp-33625	19	32	the	the	DET
bjp-33625	19	33	present	present	ADJ
bjp-33625	19	34	study	study	NOUN
bjp-33625	19	35	.	.	PUNCT
bjp-33625	20	1	article	article	NOUN
bjp-33625	20	2	info	info	NOUN
bjp-33625	20	3	received	receive	VERB
bjp-33625	20	4	:	:	PUNCT
bjp-33625	20	5	19	19	NUM
bjp-33625	20	6	august	august	PROPN
bjp-33625	20	7	2017	2017	NUM
bjp-33625	20	8	accepted	accept	VERB
bjp-33625	20	9	:	:	PUNCT
bjp-33625	20	10	12	12	NUM
bjp-33625	20	11	december	december	PROPN
bjp-33625	20	12	2017	2017	NUM
bjp-33625	20	13	available	available	ADJ
bjp-33625	20	14	online	online	NOUN
bjp-33625	20	15	:	:	PUNCT
bjp-33625	20	16	25	25	NUM
bjp-33625	20	17	january	january	PROPN
bjp-33625	20	18	2017	2017	NUM
bjp-33625	20	19	doi	doi	NOUN
bjp-33625	20	20	:	:	PUNCT
bjp-33625	20	21	10.3329	10.3329	NUM
bjp-33625	20	22	/	/	SYM
bjp-33625	20	23	bjp.v13i1.33625	bjp.v13i1.33625	PROPN
bjp-33625	20	24	cite	cite	VERB
bjp-33625	20	25	this	this	DET
bjp-33625	20	26	article	article	NOUN
bjp-33625	20	27	:	:	PUNCT
bjp-33625	20	28	lohidakshan	lohidakshan	PROPN
bjp-33625	20	29	k	k	PROPN
bjp-33625	20	30	,	,	PUNCT
bjp-33625	20	31	rajan	rajan	PROPN
bjp-33625	20	32	m	m	PROPN
bjp-33625	20	33	,	,	PUNCT
bjp-33625	20	34	ganesh	ganesh	PROPN
bjp-33625	20	35	a	a	X
bjp-33625	20	36	,	,	PUNCT
bjp-33625	20	37	paul	paul	PROPN
bjp-33625	20	38	m	m	PROPN
bjp-33625	20	39	,	,	PUNCT
bjp-33625	20	40	jerin	jerin	PROPN
bjp-33625	20	41	j.	j.	PROPN
bjp-33625	20	42	pass	pass	PROPN
bjp-33625	20	43	and	and	CCONJ
bjp-33625	20	44	swiss	swiss	ADJ
bjp-33625	20	45	adme	adme	NOUN
bjp-33625	20	46	collaborated	collaborate	VERB
bjp-33625	20	47	in	in	ADP
bjp-33625	20	48	silico	silico	NOUN
bjp-33625	20	49	docking	dock	VERB
bjp-33625	20	50	approach	approach	NOUN
bjp-33625	20	51	to	to	ADP
bjp-33625	20	52	the	the	DET
bjp-33625	20	53	synthesis	synthesis	NOUN
bjp-33625	20	54	of	of	ADP
bjp-33625	20	55	certain	certain	ADJ
bjp-33625	20	56	pyrazoline	pyrazoline	NOUN
bjp-33625	20	57	spacer	spacer	NOUN
bjp-33625	20	58	compounds	compound	NOUN
bjp-33625	20	59	for	for	ADP
bjp-33625	20	60	dihydrofolate	dihydrofolate	NOUN
bjp-33625	20	61	reductase	reductase	NOUN
bjp-33625	20	62	inhibition	inhibition	NOUN
bjp-33625	20	63	and	and	CCONJ
bjp-33625	20	64	antimalarial	antimalarial	ADJ
bjp-33625	20	65	activity	activity	NOUN
bjp-33625	20	66	.	.	PUNCT
bjp-33625	21	1	bangladesh	bangladesh	PROPN
bjp-33625	21	2	j	j	PROPN
bjp-33625	21	3	pharmacol	pharmacol	PROPN
bjp-33625	21	4	.	.	PROPN
bjp-33625	22	1	2018	2018	NUM
bjp-33625	22	2	;	;	PUNCT
bjp-33625	22	3	13	13	NUM
bjp-33625	22	4	:	:	SYM
bjp-33625	22	5	23	23	NUM
bjp-33625	22	6	-	-	SYM
bjp-33625	22	7	29	29	NUM
bjp-33625	22	8	.	.	PUNCT
bjp-33625	23	1	pass	pass	VERB
bjp-33625	23	2	and	and	CCONJ
bjp-33625	23	3	swiss	swiss	ADJ
bjp-33625	23	4	adme	adme	NOUN
bjp-33625	23	5	collaborated	collaborate	VERB
bjp-33625	23	6	in	in	ADP
bjp-33625	23	7	silico	silico	NOUN
bjp-33625	23	8	docking	dock	VERB
bjp-33625	23	9	approach	approach	NOUN
bjp-33625	23	10	to	to	ADP
bjp-33625	23	11	the	the	DET
bjp-33625	23	12	synthesis	synthesis	NOUN
bjp-33625	23	13	of	of	ADP
bjp-33625	23	14	certain	certain	ADJ
bjp-33625	23	15	pyrazoline	pyrazoline	NOUN
bjp-33625	23	16	spacer	spacer	NOUN
bjp-33625	23	17	compounds	compound	NOUN
bjp-33625	23	18	for	for	ADP
bjp-33625	23	19	dihydrofolate	dihydrofolate	NOUN
bjp-33625	23	20	reductase	reductase	NOUN
bjp-33625	23	21	inhibition	inhibition	NOUN
bjp-33625	23	22	and	and	CCONJ
bjp-33625	23	23	antimalarial	antimalarial	ADJ
bjp-33625	23	24	activity	activity	NOUN
bjp-33625	23	25	krishnakumar	krishnakumar	PROPN
bjp-33625	23	26	lohidashan1	lohidashan1	PROPN
bjp-33625	23	27	,	,	PUNCT
bjp-33625	23	28	manju	manju	PROPN
bjp-33625	23	29	rajan2	rajan2	PROPN
bjp-33625	23	30	,	,	PUNCT
bjp-33625	23	31	andhale	andhale	PROPN
bjp-33625	23	32	ganesh1	ganesh1	PROPN
bjp-33625	23	33	,	,	PUNCT
bjp-33625	23	34	mathew	mathew	PROPN
bjp-33625	23	35	paul3	paul3	PROPN
bjp-33625	23	36	and	and	CCONJ
bjp-33625	23	37	jithu	jithu	ADJ
bjp-33625	23	38	jerin1	jerin1	PROPN
bjp-33625	24	1	1department	1department	NUM
bjp-33625	24	2	of	of	ADP
bjp-33625	24	3	pharmaceutical	pharmaceutical	ADJ
bjp-33625	24	4	chemistry	chemistry	NOUN
bjp-33625	24	5	,	,	PUNCT
bjp-33625	24	6	acharya	acharya	PROPN
bjp-33625	24	7	and	and	CCONJ
bjp-33625	24	8	b.	b.	PROPN
bjp-33625	24	9	m.	m.	PROPN
bjp-33625	24	10	reddy	reddy	PROPN
bjp-33625	24	11	college	college	PROPN
bjp-33625	24	12	of	of	ADP
bjp-33625	24	13	pharmacy	pharmacy	NOUN
bjp-33625	24	14	,	,	PUNCT
bjp-33625	24	15	bengaluru	bengaluru	PROPN
bjp-33625	24	16	560107	560107	NUM
bjp-33625	24	17	,	,	PUNCT
bjp-33625	24	18	karnataka	karnataka	PROPN
bjp-33625	24	19	,	,	PUNCT
bjp-33625	24	20	india	india	PROPN
bjp-33625	24	21	;	;	PUNCT
bjp-33625	25	1	2department	2department	NUM
bjp-33625	25	2	of	of	ADP
bjp-33625	25	3	pharmaceutical	pharmaceutical	ADJ
bjp-33625	25	4	chemistry	chemistry	NOUN
bjp-33625	25	5	,	,	PUNCT
bjp-33625	25	6	nirmala	nirmala	PROPN
bjp-33625	25	7	college	college	PROPN
bjp-33625	25	8	of	of	ADP
bjp-33625	25	9	health	health	PROPN
bjp-33625	25	10	science	science	NOUN
bjp-33625	25	11	,	,	PUNCT
bjp-33625	25	12	meloor	meloor	NOUN
bjp-33625	25	13	680311	680311	NUM
bjp-33625	25	14	,	,	PUNCT
bjp-33625	25	15	kerala	kerala	PROPN
bjp-33625	25	16	,	,	PUNCT
bjp-33625	25	17	india	india	PROPN
bjp-33625	25	18	;	;	PUNCT
bjp-33625	25	19	3department	3department	NUM
bjp-33625	25	20	of	of	ADP
bjp-33625	25	21	chemistry	chemistry	NOUN
bjp-33625	25	22	,	,	PUNCT
bjp-33625	25	23	christ	christ	PROPN
bjp-33625	25	24	college	college	PROPN
bjp-33625	25	25	,	,	PUNCT
bjp-33625	25	26	irinjalakuda	irinjalakuda	NOUN
bjp-33625	25	27	680125	680125	NUM
bjp-33625	25	28	,	,	PUNCT
bjp-33625	25	29	kerala	kerala	PROPN
bjp-33625	25	30	,	,	PUNCT
bjp-33625	25	31	india	india	PROPN
bjp-33625	25	32	.	.	PUNCT
bjp-33625	26	1	this	this	DET
bjp-33625	26	2	work	work	NOUN
bjp-33625	26	3	is	be	AUX
bjp-33625	26	4	licensed	license	VERB
bjp-33625	26	5	under	under	ADP
bjp-33625	26	6	a	a	DET
bjp-33625	26	7	creative	creative	ADJ
bjp-33625	26	8	commons	common	NOUN
bjp-33625	26	9	attribution	attribution	NOUN
bjp-33625	26	10	4.0	4.0	NUM
bjp-33625	26	11	license	license	NOUN
bjp-33625	26	12	.	.	PUNCT
bjp-33625	27	1	you	you	PRON
bjp-33625	27	2	are	be	AUX
bjp-33625	27	3	free	free	ADJ
bjp-33625	27	4	to	to	PART
bjp-33625	27	5	copy	copy	VERB
bjp-33625	27	6	,	,	PUNCT
bjp-33625	27	7	distribute	distribute	VERB
bjp-33625	27	8	and	and	CCONJ
bjp-33625	27	9	perform	perform	VERB
bjp-33625	27	10	the	the	DET
bjp-33625	27	11	work	work	NOUN
bjp-33625	27	12	.	.	PUNCT
bjp-33625	28	1	you	you	PRON
bjp-33625	28	2	must	must	AUX
bjp-33625	28	3	attribute	attribute	VERB
bjp-33625	28	4	the	the	DET
bjp-33625	28	5	work	work	NOUN
bjp-33625	28	6	in	in	ADP
bjp-33625	28	7	the	the	DET
bjp-33625	28	8	manner	manner	NOUN
bjp-33625	28	9	specified	specify	VERB
bjp-33625	28	10	by	by	ADP
bjp-33625	28	11	the	the	DET
bjp-33625	28	12	author	author	NOUN
bjp-33625	28	13	or	or	CCONJ
bjp-33625	28	14	licensor	licensor	NOUN
bjp-33625	28	15	.	.	PUNCT
bjp-33625	29	1	the	the	DET
bjp-33625	29	2	effect	effect	NOUN
bjp-33625	29	3	of	of	ADP
bjp-33625	29	4	substitutions	substitution	NOUN
bjp-33625	29	5	in	in	ADP
bjp-33625	29	6	the	the	DET
bjp-33625	29	7	interaction	interaction	NOUN
bjp-33625	29	8	of	of	ADP
bjp-33625	29	9	this	this	DET
bjp-33625	29	10	molecule	molecule	NOUN
bjp-33625	29	11	to	to	ADP
bjp-33625	29	12	the	the	DET
bjp-33625	29	13	binding	bind	VERB
bjp-33625	29	14	pockets	pocket	NOUN
bjp-33625	29	15	of	of	ADP
bjp-33625	29	16	the	the	DET
bjp-33625	29	17	enzyme	enzyme	NOUN
bjp-33625	29	18	.	.	PUNCT
bjp-33625	30	1	the	the	DET
bjp-33625	30	2	title	title	NOUN
bjp-33625	30	3	compounds	compound	NOUN
bjp-33625	30	4	subjected	subject	VERB
bjp-33625	30	5	to	to	PART
bjp-33625	30	6	pass	pass	VERB
bjp-33625	30	7	online	online	ADJ
bjp-33625	30	8	bioactivity	bioactivity	NOUN
bjp-33625	30	9	prediction	prediction	NOUN
bjp-33625	30	10	(	(	PUNCT
bjp-33625	30	11	parasuraman	parasuraman	NOUN
bjp-33625	30	12	,	,	PUNCT
bjp-33625	30	13	2011	2011	NUM
bjp-33625	30	14	)	)	PUNCT
bjp-33625	30	15	.	.	PUNCT
bjp-33625	31	1	the	the	DET
bjp-33625	31	2	result	result	NOUN
bjp-33625	31	3	came	come	VERB
bjp-33625	31	4	as	as	SCONJ
bjp-33625	31	5	synthesized	synthesize	VERB
bjp-33625	31	6	compounds	compound	NOUN
bjp-33625	31	7	showed	show	VERB
bjp-33625	31	8	more	more	ADJ
bjp-33625	31	9	probabilities	probability	NOUN
bjp-33625	31	10	to	to	PART
bjp-33625	31	11	exhibit	exhibit	VERB
bjp-33625	31	12	the	the	DET
bjp-33625	31	13	antiprotozoal	antiprotozoal	ADJ
bjp-33625	31	14	activity	activity	NOUN
bjp-33625	31	15	.	.	PUNCT
bjp-33625	32	1	our	our	PRON
bjp-33625	32	2	recent	recent	ADJ
bjp-33625	32	3	study	study	NOUN
bjp-33625	32	4	on	on	ADP
bjp-33625	32	5	dihydrofolate	dihydrofolate	NOUN
bjp-33625	32	6	reductase	reductase	NOUN
bjp-33625	32	7	enzyme	enzyme	NOUN
bjp-33625	32	8	is	be	AUX
bjp-33625	32	9	a	a	DET
bjp-33625	32	10	good	good	ADJ
bjp-33625	32	11	receptor	receptor	NOUN
bjp-33625	32	12	for	for	ADP
bjp-33625	32	13	the	the	DET
bjp-33625	32	14	lipophilic	lipophilic	ADJ
bjp-33625	32	15	derivative	derivative	NOUN
bjp-33625	32	16	gave	give	VERB
bjp-33625	32	17	a	a	DET
bjp-33625	32	18	direction	direction	NOUN
bjp-33625	32	19	to	to	PART
bjp-33625	32	20	do	do	VERB
bjp-33625	32	21	a	a	DET
bjp-33625	32	22	check	check	NOUN
bjp-33625	32	23	on	on	ADP
bjp-33625	32	24	these	these	DET
bjp-33625	32	25	molecules	molecule	NOUN
bjp-33625	32	26	(	(	PUNCT
bjp-33625	32	27	krishnakumar	krishnakumar	X
bjp-33625	32	28	et	et	PROPN
bjp-33625	32	29	al	al	PROPN
bjp-33625	32	30	.	.	PROPN
bjp-33625	32	31	,	,	PUNCT
bjp-33625	32	32	2017	2017	NUM
bjp-33625	32	33	)	)	PUNCT
bjp-33625	32	34	.	.	PUNCT
bjp-33625	33	1	malarial	malarial	ADJ
bjp-33625	33	2	dihydrofolate	dihydrofolate	NOUN
bjp-33625	33	3	reductase	reductase	NOUN
bjp-33625	33	4	(	(	PUNCT
bjp-33625	33	5	dhfr	dhfr	NOUN
bjp-33625	33	6	)	)	PUNCT
bjp-33625	33	7	is	be	AUX
bjp-33625	33	8	the	the	DET
bjp-33625	33	9	target	target	NOUN
bjp-33625	33	10	of	of	ADP
bjp-33625	33	11	antifolate	antifolate	NOUN
bjp-33625	33	12	antimalarial	antimalarial	ADJ
bjp-33625	33	13	drugs	drug	NOUN
bjp-33625	33	14	.	.	PUNCT
bjp-33625	34	1	inhibition	inhibition	NOUN
bjp-33625	34	2	of	of	ADP
bjp-33625	34	3	this	this	DET
bjp-33625	34	4	enzyme	enzyme	NOUN
bjp-33625	34	5	results	result	NOUN
bjp-33625	34	6	in	in	ADP
bjp-33625	34	7	disruption	disruption	NOUN
bjp-33625	34	8	of	of	ADP
bjp-33625	34	9	dna	dna	PROPN
bjp-33625	34	10	,	,	PUNCT
bjp-33625	34	11	rna	rna	NOUN
bjp-33625	34	12	,	,	PUNCT
bjp-33625	34	13	and	and	CCONJ
bjp-33625	34	14	protein	protein	NOUN
bjp-33625	34	15	synthesis	synthesis	NOUN
bjp-33625	34	16	,	,	PUNCT
bjp-33625	34	17	with	with	ADP
bjp-33625	34	18	consequent	consequent	ADJ
bjp-33625	34	19	cell	cell	NOUN
bjp-33625	34	20	death	death	NOUN
bjp-33625	34	21	.	.	PUNCT
bjp-33625	35	1	recent	recent	ADJ
bjp-33625	35	2	studies	study	NOUN
bjp-33625	35	3	on	on	ADP
bjp-33625	35	4	available	available	ADJ
bjp-33625	35	5	antimalarials	antimalarial	NOUN
bjp-33625	35	6	say	say	VERB
bjp-33625	35	7	efficacy	efficacy	NOUN
bjp-33625	35	8	of	of	ADP
bjp-33625	35	9	these	these	DET
bjp-33625	35	10	drugs	drug	NOUN
bjp-33625	35	11	has	have	AUX
bjp-33625	35	12	decreased	decrease	VERB
bjp-33625	35	13	because	because	SCONJ
bjp-33625	35	14	of	of	ADP
bjp-33625	35	15	mutations	mutation	NOUN
bjp-33625	35	16	in	in	ADP
bjp-33625	35	17	the	the	DET
bjp-33625	35	18	enzyme	enzyme	NOUN
bjp-33625	35	19	that	that	PRON
bjp-33625	35	20	have	have	AUX
bjp-33625	35	21	led	lead	VERB
bjp-33625	35	22	to	to	ADP
bjp-33625	35	23	drug	drug	NOUN
bjp-33625	35	24	resistance	resistance	NOUN
bjp-33625	35	25	(	(	PUNCT
bjp-33625	35	26	yuthavong	yuthavong	NOUN
bjp-33625	35	27	et	et	PROPN
bjp-33625	35	28	al	al	PROPN
bjp-33625	35	29	.	.	PROPN
bjp-33625	35	30	,	,	PUNCT
bjp-33625	35	31	2012	2012	NUM
bjp-33625	35	32	)	)	PUNCT
bjp-33625	35	33	.	.	PUNCT
bjp-33625	36	1	this	this	PRON
bjp-33625	36	2	fostered	foster	VERB
bjp-33625	36	3	us	we	PRON
bjp-33625	36	4	to	to	PART
bjp-33625	36	5	screen	screen	VERB
bjp-33625	36	6	the	the	DET
bjp-33625	36	7	compounds	compound	NOUN
bjp-33625	36	8	for	for	ADP
bjp-33625	36	9	effective	effective	ADJ
bjp-33625	36	10	dihydrofolate	dihydrofolate	NOUN
bjp-33625	36	11	reductase	reductase	NOUN
bjp-33625	36	12	inhibition	inhibition	NOUN
bjp-33625	36	13	.	.	PUNCT
bjp-33625	37	1	further	furth	ADJ
bjp-33625	37	2	web	web	NOUN
bjp-33625	37	3	based	base	VERB
bjp-33625	37	4	in	in	ADP
bjp-33625	37	5	silico	silico	NOUN
bjp-33625	37	6	methods	method	NOUN
bjp-33625	37	7	like	like	ADP
bjp-33625	37	8	swiss	swiss	ADJ
bjp-33625	37	9	adme	adme	NOUN
bjp-33625	37	10	calculator	calculator	NOUN
bjp-33625	37	11	,	,	PUNCT
bjp-33625	37	12	pass	pass	VERB
bjp-33625	37	13	bioactivity	bioactivity	NOUN
bjp-33625	37	14	tester	tester	NOUN
bjp-33625	37	15	are	be	AUX
bjp-33625	37	16	implemented	implement	VERB
bjp-33625	37	17	to	to	PART
bjp-33625	37	18	study	study	VERB
bjp-33625	37	19	the	the	DET
bjp-33625	37	20	efficacy	efficacy	NOUN
bjp-33625	37	21	of	of	ADP
bjp-33625	37	22	these	these	DET
bjp-33625	37	23	compounds	compound	NOUN
bjp-33625	37	24	in	in	ADP
bjp-33625	37	25	the	the	DET
bjp-33625	37	26	due	due	ADJ
bjp-33625	37	27	course	course	NOUN
bjp-33625	37	28	of	of	ADP
bjp-33625	37	29	synthesis	synthesis	NOUN
bjp-33625	37	30	.	.	PUNCT
bjp-33625	38	1	drug	drug	NOUN
bjp-33625	38	2	design	design	NOUN
bjp-33625	38	3	involves	involve	VERB
bjp-33625	38	4	the	the	DET
bjp-33625	38	5	estimation	estimation	NOUN
bjp-33625	38	6	of	of	ADP
bjp-33625	38	7	absorption	absorption	NOUN
bjp-33625	38	8	,	,	PUNCT
bjp-33625	38	9	distribution	distribution	NOUN
bjp-33625	38	10	,	,	PUNCT
bjp-33625	38	11	metabolism	metabolism	NOUN
bjp-33625	38	12	,	,	PUNCT
bjp-33625	38	13	and	and	CCONJ
bjp-33625	38	14	excretion	excretion	NOUN
bjp-33625	38	15	(	(	PUNCT
bjp-33625	38	16	adme	adme	NOUN
bjp-33625	38	17	)	)	PUNCT
bjp-33625	38	18	increased	increase	VERB
bjp-33625	38	19	in	in	ADP
bjp-33625	38	20	the	the	DET
bjp-33625	38	21	contemporary	contemporary	ADJ
bjp-33625	38	22	discovery	discovery	NOUN
bjp-33625	38	23	process	process	NOUN
bjp-33625	38	24	(	(	PUNCT
bjp-33625	38	25	daina	daina	PROPN
bjp-33625	38	26	et	et	PROPN
bjp-33625	38	27	al	al	PROPN
bjp-33625	38	28	.	.	PROPN
bjp-33625	38	29	,	,	PUNCT
bjp-33625	38	30	2017	2017	NUM
bjp-33625	38	31	)	)	PUNCT
bjp-33625	38	32	.	.	PUNCT
bjp-33625	39	1	in	in	ADP
bjp-33625	39	2	that	that	DET
bjp-33625	39	3	context	context	NOUN
bjp-33625	39	4	,	,	PUNCT
bjp-33625	39	5	computer	computer	NOUN
bjp-33625	39	6	models	model	NOUN
bjp-33625	39	7	constitute	constitute	VERB
bjp-33625	39	8	valid	valid	ADJ
bjp-33625	39	9	alternatives	alternative	NOUN
bjp-33625	39	10	to	to	ADP
bjp-33625	39	11	experiments	experiment	NOUN
bjp-33625	39	12	.	.	PUNCT
bjp-33625	40	1	the	the	DET
bjp-33625	40	2	identified	identify	VERB
bjp-33625	40	3	molecules	molecule	NOUN
bjp-33625	40	4	are	be	AUX
bjp-33625	40	5	further	far	ADV
bjp-33625	40	6	subjected	subject	VERB
bjp-33625	40	7	to	to	ADP
bjp-33625	40	8	docking	dock	VERB
bjp-33625	40	9	study	study	NOUN
bjp-33625	40	10	using	use	VERB
bjp-33625	40	11	cdocker	cdocker	NOUN
bjp-33625	40	12	program	program	NOUN
bjp-33625	40	13	of	of	ADP
bjp-33625	40	14	accelrys	accelrys	PROPN
bjp-33625	40	15	discovery	discovery	PROPN
bjp-33625	40	16	studio	studio	NOUN
bjp-33625	40	17	3.5	3.5	NUM
bjp-33625	40	18	against	against	ADP
bjp-33625	40	19	the	the	DET
bjp-33625	40	20	dihydrofolate	dihydrofolate	ADJ
bjp-33625	40	21	reductase	reductase	NOUN
bjp-33625	40	22	enzyme	enzyme	NOUN
bjp-33625	40	23	.	.	PUNCT
bjp-33625	41	1	since	since	SCONJ
bjp-33625	41	2	the	the	DET
bjp-33625	41	3	in	in	ADP
bjp-33625	41	4	silico	silico	NOUN
bjp-33625	41	5	drug	drug	NOUN
bjp-33625	41	6	design	design	NOUN
bjp-33625	41	7	studies	study	NOUN
bjp-33625	41	8	are	be	AUX
bjp-33625	41	9	carried	carry	VERB
bjp-33625	41	10	out	out	ADP
bjp-33625	41	11	in	in	ADP
bjp-33625	41	12	an	an	DET
bjp-33625	41	13	intention	intention	NOUN
bjp-33625	41	14	to	to	PART
bjp-33625	41	15	minimize	minimize	VERB
bjp-33625	41	16	the	the	DET
bjp-33625	41	17	animal	animal	NOUN
bjp-33625	41	18	sacrifice	sacrifice	NOUN
bjp-33625	41	19	and	and	CCONJ
bjp-33625	41	20	economic	economic	ADJ
bjp-33625	41	21	burden	burden	NOUN
bjp-33625	41	22	due	due	ADP
bjp-33625	41	23	to	to	ADP
bjp-33625	41	24	clinical	clinical	ADJ
bjp-33625	41	25	studies	study	NOUN
bjp-33625	41	26	,	,	PUNCT
bjp-33625	41	27	the	the	DET
bjp-33625	41	28	pharmacological	pharmacological	ADJ
bjp-33625	41	29	screening	screening	NOUN
bjp-33625	41	30	in	in	ADP
bjp-33625	41	31	this	this	DET
bjp-33625	41	32	work	work	NOUN
bjp-33625	41	33	performed	perform	VERB
bjp-33625	41	34	with	with	ADP
bjp-33625	41	35	nonclinical	nonclinical	ADJ
bjp-33625	41	36	evaluation	evaluation	NOUN
bjp-33625	41	37	of	of	ADP
bjp-33625	41	38	the	the	DET
bjp-33625	41	39	antimalarial	antimalarial	ADJ
bjp-33625	41	40	activity	activity	NOUN
bjp-33625	41	41	.	.	PUNCT
bjp-33625	42	1	materials	material	NOUN
bjp-33625	42	2	and	and	CCONJ
bjp-33625	42	3	methods	method	NOUN
bjp-33625	42	4	molinspiration	molinspiration	VERB
bjp-33625	42	5	various	various	ADJ
bjp-33625	42	6	heterocyclic	heterocyclic	ADJ
bjp-33625	42	7	chalcones	chalcone	NOUN
bjp-33625	42	8	and	and	CCONJ
bjp-33625	42	9	acid	acid	ADJ
bjp-33625	42	10	hydrazide	hydrazide	ADV
bjp-33625	42	11	were	be	AUX
bjp-33625	42	12	considered	consider	VERB
bjp-33625	42	13	for	for	ADP
bjp-33625	42	14	virtual	virtual	ADJ
bjp-33625	42	15	screening	screening	NOUN
bjp-33625	42	16	method	method	NOUN
bjp-33625	42	17	to	to	PART
bjp-33625	42	18	check	check	VERB
bjp-33625	42	19	the	the	DET
bjp-33625	42	20	bioactivity	bioactivity	NOUN
bjp-33625	42	21	score	score	NOUN
bjp-33625	42	22	.	.	PUNCT
bjp-33625	43	1	when	when	SCONJ
bjp-33625	43	2	these	these	DET
bjp-33625	43	3	chalcones	chalcone	NOUN
bjp-33625	43	4	were	be	AUX
bjp-33625	43	5	compared	compare	VERB
bjp-33625	43	6	,	,	PUNCT
bjp-33625	43	7	benzimidazole	benzimidazole	NOUN
bjp-33625	43	8	chalcones	chalcone	NOUN
bjp-33625	43	9	and	and	CCONJ
bjp-33625	43	10	imidazole	imidazole	NOUN
bjp-33625	43	11	hydrazide	hydrazide	ADV
bjp-33625	43	12	were	be	AUX
bjp-33625	43	13	found	find	VERB
bjp-33625	43	14	to	to	PART
bjp-33625	43	15	have	have	VERB
bjp-33625	43	16	interesting	interesting	ADJ
bjp-33625	43	17	molecular	molecular	ADJ
bjp-33625	43	18	properties	property	NOUN
bjp-33625	43	19	,	,	PUNCT
bjp-33625	43	20	which	which	PRON
bjp-33625	43	21	match	match	VERB
bjp-33625	43	22	with	with	ADP
bjp-33625	43	23	lipinski	lipinski	PROPN
bjp-33625	43	24	prediction	prediction	NOUN
bjp-33625	43	25	.	.	PUNCT
bjp-33625	44	1	once	once	ADV
bjp-33625	44	2	a	a	DET
bjp-33625	44	3	bioactivity	bioactivity	NOUN
bjp-33625	44	4	model	model	NOUN
bjp-33625	44	5	is	be	AUX
bjp-33625	44	6	generated	generate	VERB
bjp-33625	44	7	,	,	PUNCT
bjp-33625	44	8	the	the	DET
bjp-33625	44	9	actual	actual	ADJ
bjp-33625	44	10	virtual	virtual	ADJ
bjp-33625	44	11	screening	screening	NOUN
bjp-33625	44	12	was	be	AUX
bjp-33625	44	13	performed	perform	VERB
bjp-33625	44	14	for	for	ADP
bjp-33625	44	15	the	the	DET
bjp-33625	44	16	predicted	predict	VERB
bjp-33625	44	17	pyrazoline	pyrazoline	NOUN
bjp-33625	44	18	molecules	molecule	NOUN
bjp-33625	44	19	.	.	PUNCT
bjp-33625	45	1	adme	adme	VERB
bjp-33625	45	2	studies	study	VERB
bjp-33625	45	3	the	the	DET
bjp-33625	45	4	adme	adme	NOUN
bjp-33625	45	5	study	study	NOUN
bjp-33625	45	6	was	be	AUX
bjp-33625	45	7	carried	carry	VERB
bjp-33625	45	8	out	out	ADP
bjp-33625	45	9	using	use	VERB
bjp-33625	45	10	swiss	swiss	ADJ
bjp-33625	45	11	adme	adme	NOUN
bjp-33625	45	12	predictor	predictor	NOUN
bjp-33625	45	13	.	.	PUNCT
bjp-33625	46	1	this	this	PRON
bjp-33625	46	2	is	be	AUX
bjp-33625	46	3	a	a	DET
bjp-33625	46	4	free	free	ADJ
bjp-33625	46	5	web	web	NOUN
bjp-33625	46	6	tool	tool	NOUN
bjp-33625	46	7	to	to	PART
bjp-33625	46	8	evaluate	evaluate	VERB
bjp-33625	46	9	the	the	DET
bjp-33625	46	10	pharmacokinetics	pharmacokinetic	NOUN
bjp-33625	46	11	,	,	PUNCT
bjp-33625	46	12	drug	drug	NOUN
bjp-33625	46	13	likeness	likeness	NOUN
bjp-33625	46	14	and	and	CCONJ
bjp-33625	46	15	medicinal	medicinal	ADJ
bjp-33625	46	16	chemistry	chemistry	NOUN
bjp-33625	46	17	friendliness	friendliness	VERB
bjp-33625	46	18	small	small	ADJ
bjp-33625	46	19	molecules	molecule	NOUN
bjp-33625	46	20	.	.	PUNCT
bjp-33625	47	1	as	as	SCONJ
bjp-33625	47	2	mentioned	mention	VERB
bjp-33625	47	3	earlier	early	ADV
bjp-33625	47	4	,	,	PUNCT
bjp-33625	47	5	the	the	DET
bjp-33625	47	6	attention	attention	NOUN
bjp-33625	47	7	was	be	AUX
bjp-33625	47	8	given	give	VERB
bjp-33625	47	9	to	to	PART
bjp-33625	47	10	design	design	VERB
bjp-33625	47	11	the	the	DET
bjp-33625	47	12	molecules	molecule	NOUN
bjp-33625	47	13	which	which	PRON
bjp-33625	47	14	fit	fit	VERB
bjp-33625	47	15	into	into	ADP
bjp-33625	47	16	the	the	DET
bjp-33625	47	17	rule	rule	NOUN
bjp-33625	47	18	of	of	ADP
bjp-33625	47	19	drug	drug	NOUN
bjp-33625	47	20	likeness	likeness	NOUN
bjp-33625	47	21	.	.	PUNCT
bjp-33625	48	1	the	the	DET
bjp-33625	48	2	properties	property	NOUN
bjp-33625	48	3	like	like	ADP
bjp-33625	48	4	molecular	molecular	ADJ
bjp-33625	48	5	weight	weight	NOUN
bjp-33625	48	6	less	less	ADJ
bjp-33625	48	7	than	than	ADP
bjp-33625	48	8	500	500	NUM
bjp-33625	48	9	g	g	NOUN
bjp-33625	48	10	/	/	SYM
bjp-33625	48	11	mol	mol	NOUN
bjp-33625	48	12	,	,	PUNCT
bjp-33625	48	13	less	less	ADJ
bjp-33625	48	14	than	than	ADP
bjp-33625	48	15	5	5	NUM
bjp-33625	48	16	numbers	number	NOUN
bjp-33625	48	17	of	of	ADP
bjp-33625	48	18	hydrogen	hydrogen	NOUN
bjp-33625	48	19	bond	bond	NOUN
bjp-33625	48	20	donors	donor	NOUN
bjp-33625	48	21	,	,	PUNCT
bjp-33625	48	22	less	less	ADJ
bjp-33625	48	23	than	than	ADP
bjp-33625	48	24	10	10	NUM
bjp-33625	48	25	numbers	number	NOUN
bjp-33625	48	26	of	of	ADP
bjp-33625	48	27	hydrogen	hydrogen	NOUN
bjp-33625	48	28	bond	bond	NOUN
bjp-33625	48	29	acceptors	acceptor	NOUN
bjp-33625	48	30	and	and	CCONJ
bjp-33625	48	31	less	less	ADJ
bjp-33625	48	32	than	than	ADP
bjp-33625	48	33	10	10	NUM
bjp-33625	48	34	rotatable	rotatable	ADJ
bjp-33625	48	35	bonds	bond	NOUN
bjp-33625	48	36	were	be	AUX
bjp-33625	48	37	chosen	choose	VERB
bjp-33625	48	38	as	as	ADP
bjp-33625	48	39	criteria	criterion	NOUN
bjp-33625	48	40	,	,	PUNCT
bjp-33625	48	41	while	while	SCONJ
bjp-33625	48	42	the	the	DET
bjp-33625	48	43	selection	selection	NOUN
bjp-33625	48	44	of	of	ADP
bjp-33625	48	45	molecules	molecule	NOUN
bjp-33625	48	46	to	to	PART
bjp-33625	48	47	be	be	AUX
bjp-33625	48	48	synthesized	synthesize	VERB
bjp-33625	48	49	(	(	PUNCT
bjp-33625	48	50	doak	doak	PROPN
bjp-33625	48	51	et	et	PROPN
bjp-33625	48	52	al	al	PROPN
bjp-33625	48	53	.	.	PROPN
bjp-33625	48	54	,	,	PUNCT
bjp-33625	48	55	2014	2014	NUM
bjp-33625	48	56	)	)	PUNCT
bjp-33625	48	57	.	.	PUNCT
bjp-33625	49	1	the	the	DET
bjp-33625	49	2	search	search	NOUN
bjp-33625	49	3	engine	engine	NOUN
bjp-33625	49	4	further	far	ADV
bjp-33625	49	5	gave	give	VERB
bjp-33625	49	6	a	a	DET
bjp-33625	49	7	compiled	compile	VERB
bjp-33625	49	8	result	result	NOUN
bjp-33625	49	9	on	on	ADP
bjp-33625	49	10	lipophilicity	lipophilicity	NOUN
bjp-33625	49	11	and	and	CCONJ
bjp-33625	49	12	hydrophilicity	hydrophilicity	NOUN
bjp-33625	49	13	of	of	ADP
bjp-33625	49	14	these	these	DET
bjp-33625	49	15	molecules	molecule	NOUN
bjp-33625	49	16	by	by	ADP
bjp-33625	49	17	integrating	integrate	VERB
bjp-33625	49	18	results	result	NOUN
bjp-33625	49	19	obtained	obtain	VERB
bjp-33625	49	20	from	from	ADP
bjp-33625	49	21	various	various	ADJ
bjp-33625	49	22	log	log	NOUN
bjp-33625	49	23	p	p	NOUN
bjp-33625	49	24	and	and	CCONJ
bjp-33625	49	25	s	s	NOUN
bjp-33625	49	26	prediction	prediction	NOUN
bjp-33625	49	27	programs	program	NOUN
bjp-33625	49	28	called	call	VERB
bjp-33625	49	29	ilogp	ilogp	NOUN
bjp-33625	49	30	,	,	PUNCT
bjp-33625	49	31	xlogp3	xlogp3	PROPN
bjp-33625	49	32	,	,	PUNCT
bjp-33625	49	33	wlogp	wlogp	NOUN
bjp-33625	49	34	,	,	PUNCT
bjp-33625	49	35	esol	esol	NOUN
bjp-33625	49	36	,	,	PUNCT
bjp-33625	49	37	and	and	CCONJ
bjp-33625	49	38	silicos	silico	NOUN
bjp-33625	49	39	-	-	PUNCT
bjp-33625	49	40	it	it	PRON
bjp-33625	49	41	.	.	PUNCT
bjp-33625	50	1	log	log	VERB
bjp-33625	50	2	p	p	NOUN
bjp-33625	50	3	,	,	PUNCT
bjp-33625	50	4	a	a	DET
bjp-33625	50	5	measure	measure	NOUN
bjp-33625	50	6	of	of	ADP
bjp-33625	50	7	lipophilicity	lipophilicity	NOUN
bjp-33625	50	8	of	of	ADP
bjp-33625	50	9	the	the	DET
bjp-33625	50	10	molecule	molecule	NOUN
bjp-33625	50	11	is	be	AUX
bjp-33625	50	12	the	the	DET
bjp-33625	50	13	logarithm	logarithm	NOUN
bjp-33625	50	14	of	of	ADP
bjp-33625	50	15	the	the	DET
bjp-33625	50	16	ratio	ratio	NOUN
bjp-33625	50	17	of	of	ADP
bjp-33625	50	18	the	the	DET
bjp-33625	50	19	concentration	concentration	NOUN
bjp-33625	50	20	of	of	ADP
bjp-33625	50	21	drug	drug	NOUN
bjp-33625	50	22	substance	substance	NOUN
bjp-33625	50	23	between	between	ADP
bjp-33625	50	24	two	two	NUM
bjp-33625	50	25	solvents	solvent	NOUN
bjp-33625	50	26	in	in	ADP
bjp-33625	50	27	an	an	DET
bjp-33625	50	28	unionized	unionized	ADJ
bjp-33625	50	29	form	form	NOUN
bjp-33625	50	30	.	.	PUNCT
bjp-33625	51	1	lipinski	lipinski	PROPN
bjp-33625	51	2	rule	rule	PROPN
bjp-33625	51	3	prescribes	prescribe	VERB
bjp-33625	51	4	an	an	DET
bjp-33625	51	5	upper	upper	ADJ
bjp-33625	51	6	limit	limit	NOUN
bjp-33625	51	7	of	of	ADP
bjp-33625	51	8	5	5	NUM
bjp-33625	51	9	for	for	ADP
bjp-33625	51	10	druggable	druggable	ADJ
bjp-33625	51	11	compounds	compound	NOUN
bjp-33625	51	12	.	.	PUNCT
bjp-33625	52	1	the	the	PRON
bjp-33625	52	2	lower	low	ADJ
bjp-33625	52	3	the	the	DET
bjp-33625	52	4	log	log	NOUN
bjp-33625	52	5	p	p	NOUN
bjp-33625	52	6	values	value	NOUN
bjp-33625	52	7	the	the	PRON
bjp-33625	52	8	stronger	strong	ADJ
bjp-33625	52	9	the	the	DET
bjp-33625	52	10	lipophilicity	lipophilicity	NOUN
bjp-33625	52	11	for	for	ADP
bjp-33625	52	12	the	the	DET
bjp-33625	52	13	chemical	chemical	ADJ
bjp-33625	52	14	substance	substance	NOUN
bjp-33625	52	15	.	.	PUNCT
bjp-33625	53	1	the	the	DET
bjp-33625	53	2	aqueous	aqueous	ADJ
bjp-33625	53	3	solubility	solubility	NOUN
bjp-33625	53	4	of	of	ADP
bjp-33625	53	5	a	a	DET
bjp-33625	53	6	compound	compound	NOUN
bjp-33625	53	7	significantly	significantly	ADV
bjp-33625	53	8	affects	affect	VERB
bjp-33625	53	9	its	its	PRON
bjp-33625	53	10	absorption	absorption	NOUN
bjp-33625	53	11	and	and	CCONJ
bjp-33625	53	12	distribution	distribution	NOUN
bjp-33625	53	13	characteristics	characteristic	NOUN
bjp-33625	53	14	.	.	PUNCT
bjp-33625	54	1	on	on	ADP
bjp-33625	54	2	the	the	DET
bjp-33625	54	3	other	other	ADJ
bjp-33625	54	4	side	side	NOUN
bjp-33625	54	5	,	,	PUNCT
bjp-33625	54	6	low	low	ADJ
bjp-33625	54	7	water	water	NOUN
bjp-33625	54	8	solubility	solubility	NOUN
bjp-33625	54	9	goes	go	VERB
bjp-33625	54	10	along	along	ADV
bjp-33625	54	11	with	with	ADP
bjp-33625	54	12	a	a	DET
bjp-33625	54	13	bad	bad	ADJ
bjp-33625	54	14	absorption	absorption	NOUN
bjp-33625	54	15	,	,	PUNCT
bjp-33625	54	16	and	and	CCONJ
bjp-33625	54	17	therefore	therefore	ADV
bjp-33625	54	18	,	,	PUNCT
bjp-33625	54	19	the	the	DET
bjp-33625	54	20	general	general	ADJ
bjp-33625	54	21	aim	aim	NOUN
bjp-33625	54	22	is	be	AUX
bjp-33625	54	23	to	to	PART
bjp-33625	54	24	avoid	avoid	VERB
bjp-33625	54	25	poorly	poorly	ADV
bjp-33625	54	26	soluble	soluble	ADJ
bjp-33625	54	27	compounds	compound	NOUN
bjp-33625	54	28	.	.	PUNCT
bjp-33625	55	1	log	log	NOUN
bjp-33625	55	2	s	s	PART
bjp-33625	55	3	is	be	AUX
bjp-33625	55	4	a	a	DET
bjp-33625	55	5	unit	unit	NOUN
bjp-33625	55	6	of	of	ADP
bjp-33625	55	7	expressing	express	VERB
bjp-33625	55	8	solubility	solubility	NOUN
bjp-33625	55	9	in	in	ADP
bjp-33625	55	10	itself	itself	PRON
bjp-33625	55	11	,	,	PUNCT
bjp-33625	55	12	which	which	PRON
bjp-33625	55	13	is	be	AUX
bjp-33625	55	14	the	the	DET
bjp-33625	55	15	10	10	NUM
bjp-33625	55	16	-	-	PUNCT
bjp-33625	55	17	based	base	VERB
bjp-33625	55	18	logarithm	logarithm	NOUN
bjp-33625	55	19	of	of	ADP
bjp-33625	55	20	the	the	DET
bjp-33625	55	21	solubility	solubility	NOUN
bjp-33625	55	22	measured	measure	VERB
bjp-33625	55	23	in	in	ADP
bjp-33625	55	24	mol	mol	PROPN
bjp-33625	55	25	/	/	SYM
bjp-33625	55	26	l.	l.	NOUN
bjp-33625	55	27	distribution	distribution	NOUN
bjp-33625	55	28	of	of	ADP
bjp-33625	55	29	log	log	NOUN
bjp-33625	55	30	s	s	PRON
bjp-33625	55	31	in	in	ADP
bjp-33625	55	32	traded	trade	VERB
bjp-33625	55	33	drugs	drug	NOUN
bjp-33625	55	34	reveals	reveal	VERB
bjp-33625	55	35	a	a	DET
bjp-33625	55	36	value	value	NOUN
bjp-33625	55	37	somewhere	somewhere	ADV
bjp-33625	55	38	between	between	ADP
bjp-33625	55	39	-1	-1	INTJ
bjp-33625	55	40	to	to	ADP
bjp-33625	55	41	-4	-4	PROPN
bjp-33625	55	42	,	,	PUNCT
bjp-33625	55	43	will	will	AUX
bjp-33625	55	44	be	be	AUX
bjp-33625	55	45	optimum	optimum	ADJ
bjp-33625	55	46	for	for	ADP
bjp-33625	55	47	better	well	ADJ
bjp-33625	55	48	absorption	absorption	NOUN
bjp-33625	55	49	and	and	CCONJ
bjp-33625	55	50	distribution	distribution	NOUN
bjp-33625	55	51	of	of	ADP
bjp-33625	55	52	drugs	drug	NOUN
bjp-33625	55	53	in	in	ADP
bjp-33625	55	54	the	the	DET
bjp-33625	55	55	body	body	NOUN
bjp-33625	55	56	.	.	PUNCT
bjp-33625	56	1	activity	activity	NOUN
bjp-33625	56	2	prediction	prediction	NOUN
bjp-33625	56	3	and	and	CCONJ
bjp-33625	56	4	toxicity	toxicity	NOUN
bjp-33625	56	5	pass	pass	VERB
bjp-33625	56	6	online	online	ADJ
bjp-33625	56	7	predicts	predict	NOUN
bjp-33625	56	8	over	over	ADP
bjp-33625	56	9	4000	4000	NUM
bjp-33625	56	10	kinds	kind	NOUN
bjp-33625	56	11	of	of	ADP
bjp-33625	56	12	biological	biological	ADJ
bjp-33625	56	13	activity	activity	NOUN
bjp-33625	56	14	,	,	PUNCT
bjp-33625	56	15	including	include	VERB
bjp-33625	56	16	pharmacological	pharmacological	ADJ
bjp-33625	56	17	effects	effect	NOUN
bjp-33625	56	18	been	be	AUX
bjp-33625	56	19	utilized	utilize	VERB
bjp-33625	56	20	for	for	ADP
bjp-33625	56	21	this	this	DET
bjp-33625	56	22	study	study	NOUN
bjp-33625	56	23	to	to	PART
bjp-33625	56	24	check	check	VERB
bjp-33625	56	25	the	the	DET
bjp-33625	56	26	bioactivity	bioactivity	NOUN
bjp-33625	56	27	score	score	NOUN
bjp-33625	56	28	of	of	ADP
bjp-33625	56	29	synthesized	synthesize	VERB
bjp-33625	56	30	compounds	compound	NOUN
bjp-33625	56	31	as	as	ADP
bjp-33625	56	32	antimalarial	antimalarial	ADJ
bjp-33625	56	33	drugs	drug	NOUN
bjp-33625	56	34	.	.	PUNCT
bjp-33625	57	1	further	further	PROPN
bjp-33625	57	2	preadmet	preadmet	PROPN
bjp-33625	57	3	ver	ver	PROPN
bjp-33625	57	4	.	.	PUNCT
bjp-33625	58	1	2.0	2.0	NUM
bjp-33625	58	2	toxicity	toxicity	NOUN
bjp-33625	58	3	predictor	predictor	NOUN
bjp-33625	58	4	predicts	predict	VERB
bjp-33625	58	5	test	test	NOUN
bjp-33625	58	6	values	value	NOUN
bjp-33625	58	7	for	for	ADP
bjp-33625	58	8	ames	ame	NOUN
bjp-33625	58	9	test	test	NOUN
bjp-33625	58	10	and	and	CCONJ
bjp-33625	58	11	rodent	rodent	VERB
bjp-33625	58	12	carcinogenicity	carcinogenicity	NOUN
bjp-33625	58	13	assay	assay	NOUN
bjp-33625	58	14	from	from	ADP
bjp-33625	58	15	the	the	DET
bjp-33625	58	16	available	available	ADJ
bjp-33625	58	17	database	database	NOUN
bjp-33625	58	18	of	of	ADP
bjp-33625	58	19	compounds	compound	NOUN
bjp-33625	58	20	of	of	ADP
bjp-33625	58	21	similar	similar	ADJ
bjp-33625	58	22	structure	structure	NOUN
bjp-33625	58	23	.	.	PUNCT
bjp-33625	59	1	this	this	DET
bjp-33625	59	2	web	web	NOUN
bjp-33625	59	3	service	service	NOUN
bjp-33625	59	4	is	be	AUX
bjp-33625	59	5	used	use	VERB
bjp-33625	59	6	for	for	ADP
bjp-33625	59	7	finding	find	VERB
bjp-33625	59	8	mutagenic	mutagenic	NOUN
bjp-33625	59	9	and	and	CCONJ
bjp-33625	59	10	carcinogenicity	carcinogenicity	NOUN
bjp-33625	59	11	of	of	ADP
bjp-33625	59	12	synthesized	synthesize	VERB
bjp-33625	59	13	compounds	compound	NOUN
bjp-33625	59	14	.	.	PUNCT
bjp-33625	60	1	docking	dock	VERB
bjp-33625	60	2	studies	study	NOUN
bjp-33625	60	3	molecular	molecular	ADJ
bjp-33625	60	4	docking	docking	NOUN
bjp-33625	60	5	study	study	NOUN
bjp-33625	60	6	for	for	ADP
bjp-33625	60	7	the	the	DET
bjp-33625	60	8	inhibition	inhibition	NOUN
bjp-33625	60	9	of	of	ADP
bjp-33625	60	10	dihydrofolate	dihydrofolate	ADJ
bjp-33625	60	11	reductase	reductase	NOUN
bjp-33625	60	12	was	be	AUX
bjp-33625	60	13	studied	study	VERB
bjp-33625	60	14	.	.	PUNCT
bjp-33625	61	1	a	a	DET
bjp-33625	61	2	number	number	NOUN
bjp-33625	61	3	of	of	ADP
bjp-33625	61	4	inhibitions	inhibition	NOUN
bjp-33625	61	5	made	make	VERB
bjp-33625	61	6	by	by	ADP
bjp-33625	61	7	the	the	DET
bjp-33625	61	8	different	different	ADJ
bjp-33625	61	9	derivatives	derivative	NOUN
bjp-33625	61	10	were	be	AUX
bjp-33625	61	11	studied	study	VERB
bjp-33625	61	12	by	by	ADP
bjp-33625	61	13	evaluating	evaluate	VERB
bjp-33625	61	14	the	the	DET
bjp-33625	61	15	result	result	NOUN
bjp-33625	61	16	obtained	obtain	VERB
bjp-33625	61	17	after	after	ADP
bjp-33625	61	18	docking	dock	VERB
bjp-33625	61	19	the	the	DET
bjp-33625	61	20	com24	com24	PROPN
bjp-33625	61	21	bangladesh	bangladesh	PROPN
bjp-33625	61	22	j	j	PROPN
bjp-33625	61	23	pharmacol	pharmacol	PROPN
bjp-33625	61	24	2018	2018	NUM
bjp-33625	61	25	;	;	PUNCT
bjp-33625	61	26	13	13	NUM
bjp-33625	61	27	:	:	SYM
bjp-33625	61	28	23	23	NUM
bjp-33625	61	29	-	-	SYM
bjp-33625	61	30	29	29	NUM
bjp-33625	61	31	figure	figure	NOUN
bjp-33625	61	32	1	1	NUM
bjp-33625	61	33	:	:	PUNCT
bjp-33625	61	34	pictorial	pictorial	ADJ
bjp-33625	61	35	representation	representation	NOUN
bjp-33625	61	36	of	of	ADP
bjp-33625	61	37	molecule	molecule	NOUN
bjp-33625	61	38	with	with	ADP
bjp-33625	61	39	spacer	spacer	NOUN
bjp-33625	61	40	and	and	CCONJ
bjp-33625	61	41	bulky	bulky	ADJ
bjp-33625	61	42	group	group	NOUN
bjp-33625	61	43	pounds	pound	NOUN
bjp-33625	61	44	using	use	VERB
bjp-33625	61	45	cdocker	cdocker	NOUN
bjp-33625	61	46	program	program	NOUN
bjp-33625	61	47	.	.	PUNCT
bjp-33625	62	1	the	the	DET
bjp-33625	62	2	scoring	scoring	NOUN
bjp-33625	62	3	functions	function	NOUN
bjp-33625	62	4	and	and	CCONJ
bjp-33625	62	5	hydrogen	hydrogen	NOUN
bjp-33625	62	6	bonds	bond	NOUN
bjp-33625	62	7	formed	form	VERB
bjp-33625	62	8	with	with	ADP
bjp-33625	62	9	the	the	DET
bjp-33625	62	10	surrounding	surround	VERB
bjp-33625	62	11	amino	amino	ADJ
bjp-33625	62	12	acids	acid	NOUN
bjp-33625	62	13	were	be	AUX
bjp-33625	62	14	used	use	VERB
bjp-33625	62	15	to	to	PART
bjp-33625	62	16	predict	predict	VERB
bjp-33625	62	17	their	their	PRON
bjp-33625	62	18	level	level	NOUN
bjp-33625	62	19	of	of	ADP
bjp-33625	62	20	inhibition	inhibition	NOUN
bjp-33625	62	21	on	on	ADP
bjp-33625	62	22	binding	bind	VERB
bjp-33625	62	23	sites	site	NOUN
bjp-33625	62	24	of	of	ADP
bjp-33625	62	25	dihydrofolate	dihydrofolate	ADJ
bjp-33625	62	26	reductase	reductase	NOUN
bjp-33625	62	27	receptor	receptor	NOUN
bjp-33625	62	28	.	.	PUNCT
bjp-33625	63	1	the	the	DET
bjp-33625	63	2	structure	structure	NOUN
bjp-33625	63	3	of	of	ADP
bjp-33625	63	4	1-[3-(1h	1-[3-(1h	PROPN
bjp-33625	63	5	-	-	PUNCT
bjp-33625	63	6	benzoimidazol-2	benzoimidazol-2	PROPN
bjp-33625	63	7	-	-	PUNCT
bjp-33625	63	8	yl)4	yl)4	PROPN
bjp-33625	63	9	,	,	PUNCT
bjp-33625	63	10	5dihydro	5dihydro	PROPN
bjp-33625	63	11	-	-	PUNCT
bjp-33625	63	12	pyrazol-1	pyrazol-1	NUM
bjp-33625	63	13	-	-	PUNCT
bjp-33625	63	14	yl]-2-(2	yl]-2-(2	NOUN
bjp-33625	63	15	-	-	PUNCT
bjp-33625	63	16	methyl-5	methyl-5	NOUN
bjp-33625	63	17	-	-	PUNCT
bjp-33625	63	18	nitro	nitro	NOUN
bjp-33625	63	19	-	-	PUNCT
bjp-33625	63	20	imidazol-1yl)-ethanone	imidazol-1yl)-ethanone	NUM
bjp-33625	63	21	derivatives	derivative	NOUN
bjp-33625	63	22	were	be	AUX
bjp-33625	63	23	docked	dock	VERB
bjp-33625	63	24	using	use	VERB
bjp-33625	63	25	accelrys	accelry	NOUN
bjp-33625	63	26	drug	drug	NOUN
bjp-33625	63	27	discovery	discovery	PROPN
bjp-33625	63	28	studio	studio	NOUN
bjp-33625	63	29	3.5	3.5	NUM
bjp-33625	63	30	.	.	PUNCT
bjp-33625	64	1	the	the	DET
bjp-33625	64	2	structure	structure	NOUN
bjp-33625	64	3	of	of	ADP
bjp-33625	64	4	the	the	DET
bjp-33625	64	5	enzyme	enzyme	NOUN
bjp-33625	64	6	dihydrofolate	dihydrofolate	NOUN
bjp-33625	64	7	reductase	reductase	NOUN
bjp-33625	64	8	was	be	AUX
bjp-33625	64	9	obtained	obtain	VERB
bjp-33625	64	10	from	from	ADP
bjp-33625	64	11	protein	protein	NOUN
bjp-33625	64	12	data	datum	NOUN
bjp-33625	64	13	bank	bank	PROPN
bjp-33625	64	14	(	(	PUNCT
bjp-33625	64	15	pdb	pdb	PROPN
bjp-33625	64	16	code	code	PROPN
bjp-33625	64	17	:	:	PUNCT
bjp-33625	64	18	7	7	NUM
bjp-33625	64	19	dfr	dfr	NOUN
bjp-33625	64	20	)	)	PUNCT
bjp-33625	64	21	and	and	CCONJ
bjp-33625	64	22	was	be	AUX
bjp-33625	64	23	used	use	VERB
bjp-33625	64	24	for	for	ADP
bjp-33625	64	25	docking	docking	NOUN
bjp-33625	64	26	.	.	PUNCT
bjp-33625	65	1	the	the	DET
bjp-33625	65	2	pose	pose	VERB
bjp-33625	65	3	with	with	ADP
bjp-33625	65	4	the	the	DET
bjp-33625	65	5	most	most	ADV
bjp-33625	65	6	negative	negative	ADJ
bjp-33625	65	7	cdocker	cdocker	NOUN
bjp-33625	65	8	interaction	interaction	NOUN
bjp-33625	65	9	value	value	NOUN
bjp-33625	65	10	of	of	ADP
bjp-33625	65	11	the	the	DET
bjp-33625	65	12	compound	compound	NOUN
bjp-33625	65	13	was	be	AUX
bjp-33625	65	14	considered	consider	VERB
bjp-33625	65	15	to	to	PART
bjp-33625	65	16	be	be	AUX
bjp-33625	65	17	the	the	DET
bjp-33625	65	18	most	most	ADV
bjp-33625	65	19	favorable	favorable	ADJ
bjp-33625	65	20	pose	pose	NOUN
bjp-33625	65	21	having	have	VERB
bjp-33625	65	22	highest	high	ADJ
bjp-33625	65	23	inhibition	inhibition	NOUN
bjp-33625	65	24	of	of	ADP
bjp-33625	65	25	dhfr	dhfr	NOUN
bjp-33625	65	26	.	.	PUNCT
bjp-33625	66	1	synthesis	synthesis	NOUN
bjp-33625	66	2	of	of	ADP
bjp-33625	66	3	1-[3-(1h	1-[3-(1h	PROPN
bjp-33625	66	4	-	-	PUNCT
bjp-33625	66	5	benzoimidazol-2	benzoimidazol-2	NUM
bjp-33625	66	6	-	-	PUNCT
bjp-33625	66	7	yl)-4,5	yl)-4,5	NOUN
bjp-33625	66	8	-	-	PUNCT
bjp-33625	66	9	dihydropyrazol-1	dihydropyrazol-1	NUM
bjp-33625	66	10	-	-	PUNCT
bjp-33625	66	11	yl]-2-(2	yl]-2-(2	NOUN
bjp-33625	66	12	-	-	PUNCT
bjp-33625	66	13	methyl-5	methyl-5	NOUN
bjp-33625	66	14	-	-	PUNCT
bjp-33625	66	15	nitro	nitro	NOUN
bjp-33625	66	16	-	-	PUNCT
bjp-33625	66	17	imidazol-1	imidazol-1	PRON
bjp-33625	66	18	-	-	PUNCT
bjp-33625	66	19	yl)ethanone	yl)ethanone	NOUN
bjp-33625	66	20	derivatives	derivative	NOUN
bjp-33625	66	21	are	be	AUX
bjp-33625	66	22	described	describe	VERB
bjp-33625	66	23	here	here	ADV
bjp-33625	66	24	as	as	ADP
bjp-33625	66	25	three	three	NUM
bjp-33625	66	26	schemes	scheme	NOUN
bjp-33625	66	27	.	.	PUNCT
bjp-33625	67	1	scheme	scheme	NOUN
bjp-33625	67	2	1	1	NUM
bjp-33625	67	3	step	step	NOUN
bjp-33625	67	4	1	1	NUM
bjp-33625	67	5	:	:	PUNCT
bjp-33625	67	6	synthesis	synthesis	NOUN
bjp-33625	67	7	of	of	ADP
bjp-33625	67	8	2-(α	2-(α	NUM
bjp-33625	67	9	-	-	PUNCT
bjp-33625	67	10	hydroxy	hydroxy	PROPN
bjp-33625	67	11	ethyl	ethyl	PROPN
bjp-33625	67	12	)	)	PUNCT
bjp-33625	67	13	benzimidazole	benzimidazole	NOUN
bjp-33625	67	14	(	(	PUNCT
bjp-33625	67	15	nyati	nyati	PROPN
bjp-33625	67	16	et	et	PROPN
bjp-33625	67	17	al	al	PROPN
bjp-33625	67	18	.	.	PROPN
bjp-33625	67	19	,	,	PUNCT
bjp-33625	67	20	2006	2006	NUM
bjp-33625	67	21	)	)	PUNCT
bjp-33625	67	22	.	.	PUNCT
bjp-33625	68	1	a	a	DET
bjp-33625	68	2	mixture	mixture	NOUN
bjp-33625	68	3	of	of	ADP
bjp-33625	68	4	ortho	ortho	PROPN
bjp-33625	68	5	-	-	PUNCT
bjp-33625	68	6	phenylenediamine	phenylenediamine	NOUN
bjp-33625	68	7	(	(	PUNCT
bjp-33625	68	8	0.25	0.25	NUM
bjp-33625	68	9	m	m	NOUN
bjp-33625	68	10	)	)	PUNCT
bjp-33625	68	11	and	and	CCONJ
bjp-33625	68	12	lactic	lactic	ADJ
bjp-33625	68	13	acid	acid	NOUN
bjp-33625	68	14	(	(	PUNCT
bjp-33625	68	15	0.35	0.35	NUM
bjp-33625	68	16	m	m	NOUN
bjp-33625	68	17	)	)	PUNCT
bjp-33625	68	18	was	be	AUX
bjp-33625	68	19	refluxed	refluxe	VERB
bjp-33625	68	20	for	for	ADP
bjp-33625	68	21	2.5	2.5	NUM
bjp-33625	68	22	hours	hour	NOUN
bjp-33625	68	23	.	.	PUNCT
bjp-33625	69	1	the	the	DET
bjp-33625	69	2	reaction	reaction	NOUN
bjp-33625	69	3	mixture	mixture	NOUN
bjp-33625	69	4	was	be	AUX
bjp-33625	69	5	cooled	cool	VERB
bjp-33625	69	6	and	and	CCONJ
bjp-33625	69	7	made	make	VERB
bjp-33625	69	8	alkaline	alkaline	NOUN
bjp-33625	69	9	by	by	ADP
bjp-33625	69	10	gradual	gradual	ADJ
bjp-33625	69	11	addition	addition	NOUN
bjp-33625	69	12	of	of	ADP
bjp-33625	69	13	10	10	NUM
bjp-33625	69	14	%	%	NOUN
bjp-33625	69	15	naoh	naoh	NOUN
bjp-33625	69	16	.	.	PUNCT
bjp-33625	70	1	the	the	DET
bjp-33625	70	2	residue	residue	NOUN
bjp-33625	70	3	was	be	AUX
bjp-33625	70	4	collected	collect	VERB
bjp-33625	70	5	.	.	PUNCT
bjp-33625	71	1	the	the	DET
bjp-33625	71	2	crude	crude	ADJ
bjp-33625	71	3	product	product	NOUN
bjp-33625	71	4	obtained	obtain	VERB
bjp-33625	71	5	was	be	AUX
bjp-33625	71	6	dissolved	dissolve	VERB
bjp-33625	71	7	in	in	ADP
bjp-33625	71	8	400	400	NUM
bjp-33625	71	9	ml	ml	NOUN
bjp-33625	71	10	of	of	ADP
bjp-33625	71	11	boiling	boiling	NOUN
bjp-33625	71	12	water	water	NOUN
bjp-33625	71	13	.	.	PUNCT
bjp-33625	72	1	to	to	ADP
bjp-33625	72	2	this	this	PRON
bjp-33625	72	3	,	,	PUNCT
bjp-33625	72	4	2	2	NUM
bjp-33625	72	5	g	g	NOUN
bjp-33625	72	6	of	of	ADP
bjp-33625	72	7	decolorizing	decolorize	VERB
bjp-33625	72	8	carbon	carbon	NOUN
bjp-33625	72	9	was	be	AUX
bjp-33625	72	10	added	add	VERB
bjp-33625	72	11	and	and	CCONJ
bjp-33625	72	12	heated	heat	VERB
bjp-33625	72	13	for	for	ADP
bjp-33625	72	14	15	15	NUM
bjp-33625	72	15	min	min	NOUN
bjp-33625	72	16	.	.	PUNCT
bjp-33625	73	1	the	the	DET
bjp-33625	73	2	mixture	mixture	NOUN
bjp-33625	73	3	was	be	AUX
bjp-33625	73	4	filtered	filter	VERB
bjp-33625	73	5	rapidly	rapidly	ADV
bjp-33625	73	6	at	at	ADP
bjp-33625	73	7	the	the	DET
bjp-33625	73	8	pump	pump	NOUN
bjp-33625	73	9	through	through	ADP
bjp-33625	73	10	preheated	preheat	VERB
bjp-33625	73	11	buchner	buchner	NOUN
bjp-33625	73	12	funnel	funnel	NOUN
bjp-33625	73	13	.	.	PUNCT
bjp-33625	74	1	the	the	DET
bjp-33625	74	2	filtrate	filtrate	NOUN
bjp-33625	74	3	was	be	AUX
bjp-33625	74	4	cooled	cool	VERB
bjp-33625	74	5	to	to	ADP
bjp-33625	74	6	about	about	ADV
bjp-33625	74	7	10	10	NUM
bjp-33625	74	8	°	°	NOUN
bjp-33625	74	9	c	c	NOUN
bjp-33625	74	10	.	.	PUNCT
bjp-33625	75	1	the	the	DET
bjp-33625	75	2	product	product	NOUN
bjp-33625	75	3	obtained	obtain	VERB
bjp-33625	75	4	was	be	AUX
bjp-33625	75	5	filtered	filter	VERB
bjp-33625	75	6	and	and	CCONJ
bjp-33625	75	7	washed	wash	VERB
bjp-33625	75	8	with	with	ADP
bjp-33625	75	9	25	25	NUM
bjp-33625	75	10	ml	ml	NOUN
bjp-33625	75	11	of	of	ADP
bjp-33625	75	12	cold	cold	ADJ
bjp-33625	75	13	water	water	NOUN
bjp-33625	75	14	and	and	CCONJ
bjp-33625	75	15	dried	dry	VERB
bjp-33625	75	16	at	at	ADP
bjp-33625	75	17	100	100	NUM
bjp-33625	75	18	°	°	NOUN
bjp-33625	75	19	c	c	NOUN
bjp-33625	75	20	.	.	PUNCT
bjp-33625	76	1	the	the	DET
bjp-33625	76	2	purity	purity	NOUN
bjp-33625	76	3	of	of	ADP
bjp-33625	76	4	the	the	DET
bjp-33625	76	5	compound	compound	NOUN
bjp-33625	76	6	was	be	AUX
bjp-33625	76	7	confirmed	confirm	VERB
bjp-33625	76	8	by	by	ADP
bjp-33625	76	9	getting	get	VERB
bjp-33625	76	10	a	a	DET
bjp-33625	76	11	single	single	ADJ
bjp-33625	76	12	spot	spot	NOUN
bjp-33625	76	13	in	in	ADP
bjp-33625	76	14	thin	thin	ADJ
bjp-33625	76	15	layer	layer	NOUN
bjp-33625	76	16	chromatography	chromatography	NOUN
bjp-33625	76	17	(	(	PUNCT
bjp-33625	76	18	tlc	tlc	NOUN
bjp-33625	76	19	)	)	PUNCT
bjp-33625	76	20	.	.	PUNCT
bjp-33625	77	1	step	step	NOUN
bjp-33625	77	2	2	2	NUM
bjp-33625	77	3	:	:	PUNCT
bjp-33625	77	4	synthesis	synthesis	NOUN
bjp-33625	77	5	of	of	ADP
bjp-33625	77	6	2	2	NUM
bjp-33625	77	7	-	-	PUNCT
bjp-33625	77	8	acetyl	acetyl	NOUN
bjp-33625	77	9	benzimidazole	benzimidazole	NOUN
bjp-33625	77	10	to	to	ADP
bjp-33625	77	11	the	the	DET
bjp-33625	77	12	solution	solution	NOUN
bjp-33625	77	13	of	of	ADP
bjp-33625	77	14	2-(hydroxy	2-(hydroxy	NUM
bjp-33625	77	15	ethyl	ethyl	NOUN
bjp-33625	77	16	)	)	PUNCT
bjp-33625	77	17	benzimidazole	benzimidazole	NOUN
bjp-33625	77	18	(	(	PUNCT
bjp-33625	77	19	50	50	NUM
bjp-33625	77	20	mm	mm	NOUN
bjp-33625	77	21	)	)	PUNCT
bjp-33625	77	22	in	in	ADP
bjp-33625	77	23	diluted	diluted	ADJ
bjp-33625	77	24	h2so4	h2so4	PROPN
bjp-33625	77	25	(	(	PUNCT
bjp-33625	77	26	5	5	NUM
bjp-33625	77	27	%	%	NOUN
bjp-33625	77	28	,	,	PUNCT
bjp-33625	77	29	40	40	NUM
bjp-33625	77	30	ml	ml	NOUN
bjp-33625	77	31	)	)	PUNCT
bjp-33625	77	32	,	,	PUNCT
bjp-33625	77	33	a	a	DET
bjp-33625	77	34	solution	solution	NOUN
bjp-33625	77	35	of	of	ADP
bjp-33625	77	36	k2cr2o7	k2cr2o7	NOUN
bjp-33625	77	37	(	(	PUNCT
bjp-33625	77	38	150	150	NUM
bjp-33625	77	39	mm	mm	NOUN
bjp-33625	77	40	)	)	PUNCT
bjp-33625	77	41	in	in	ADP
bjp-33625	77	42	aqueous	aqueous	ADJ
bjp-33625	77	43	h2so4	h2so4	PROPN
bjp-33625	77	44	(	(	PUNCT
bjp-33625	77	45	25	25	NUM
bjp-33625	77	46	%	%	NOUN
bjp-33625	77	47	,	,	PUNCT
bjp-33625	77	48	80	80	NUM
bjp-33625	77	49	ml	ml	NOUN
bjp-33625	77	50	)	)	PUNCT
bjp-33625	77	51	was	be	AUX
bjp-33625	77	52	added	add	VERB
bjp-33625	77	53	over	over	ADP
bjp-33625	77	54	a	a	DET
bjp-33625	77	55	period	period	NOUN
bjp-33625	77	56	of	of	ADP
bjp-33625	77	57	20	20	NUM
bjp-33625	77	58	min	min	NOUN
bjp-33625	77	59	.	.	PUNCT
bjp-33625	78	1	the	the	DET
bjp-33625	78	2	mixture	mixture	NOUN
bjp-33625	78	3	was	be	AUX
bjp-33625	78	4	then	then	ADV
bjp-33625	78	5	stirred	stir	VERB
bjp-33625	78	6	further	far	ADV
bjp-33625	78	7	for	for	ADP
bjp-33625	78	8	2	2	NUM
bjp-33625	78	9	hours	hour	NOUN
bjp-33625	78	10	.	.	PUNCT
bjp-33625	79	1	the	the	DET
bjp-33625	79	2	separated	separate	VERB
bjp-33625	79	3	orange	orange	PROPN
bjp-33625	79	4	solid	solid	ADJ
bjp-33625	79	5	was	be	AUX
bjp-33625	79	6	washed	wash	VERB
bjp-33625	79	7	with	with	ADP
bjp-33625	79	8	water	water	NOUN
bjp-33625	79	9	,	,	PUNCT
bjp-33625	79	10	then	then	ADV
bjp-33625	79	11	suspended	suspend	VERB
bjp-33625	79	12	in	in	ADP
bjp-33625	79	13	water	water	NOUN
bjp-33625	79	14	(	(	PUNCT
bjp-33625	79	15	50	50	NUM
bjp-33625	79	16	ml	ml	NOUN
bjp-33625	79	17	)	)	PUNCT
bjp-33625	79	18	and	and	CCONJ
bjp-33625	79	19	treated	treat	VERB
bjp-33625	79	20	with	with	ADP
bjp-33625	79	21	aqueous	aqueous	ADJ
bjp-33625	79	22	nh3	nh3	PROPN
bjp-33625	79	23	(	(	PUNCT
bjp-33625	79	24	1:1	1:1	NUM
bjp-33625	79	25	)	)	PUNCT
bjp-33625	79	26	to	to	ADP
bjp-33625	79	27	a	a	DET
bjp-33625	79	28	ph	ph	ADJ
bjp-33625	79	29	6.0	6.0	NUM
bjp-33625	79	30	-	-	SYM
bjp-33625	79	31	6.5	6.5	NUM
bjp-33625	79	32	.	.	PUNCT
bjp-33625	80	1	the	the	DET
bjp-33625	80	2	separated	separate	VERB
bjp-33625	80	3	solid	solid	ADJ
bjp-33625	80	4	was	be	AUX
bjp-33625	80	5	washed	wash	VERB
bjp-33625	80	6	with	with	ADP
bjp-33625	80	7	water	water	NOUN
bjp-33625	80	8	,	,	PUNCT
bjp-33625	80	9	dried	dry	VERB
bjp-33625	80	10	and	and	CCONJ
bjp-33625	80	11	recrystallized	recrystallize	VERB
bjp-33625	80	12	from	from	ADP
bjp-33625	80	13	boiling	boil	VERB
bjp-33625	80	14	ethyl	ethyl	PROPN
bjp-33625	80	15	acetate	acetate	NOUN
bjp-33625	80	16	.	.	PUNCT
bjp-33625	81	1	a	a	DET
bjp-33625	81	2	single	single	ADJ
bjp-33625	81	3	spot	spot	NOUN
bjp-33625	81	4	in	in	ADP
bjp-33625	81	5	the	the	DET
bjp-33625	81	6	tlc	tlc	NOUN
bjp-33625	81	7	plate	plate	NOUN
bjp-33625	81	8	confirmed	confirm	VERB
bjp-33625	81	9	the	the	DET
bjp-33625	81	10	purity	purity	NOUN
bjp-33625	81	11	.	.	PUNCT
bjp-33625	82	1	step	step	NOUN
bjp-33625	82	2	3	3	NUM
bjp-33625	82	3	:	:	PUNCT
bjp-33625	82	4	synthesis	synthesis	NOUN
bjp-33625	82	5	of	of	ADP
bjp-33625	82	6	benzimidazole	benzimidazole	PROPN
bjp-33625	82	7	chalcones	chalcone	NOUN
bjp-33625	82	8	to	to	ADP
bjp-33625	82	9	a	a	DET
bjp-33625	82	10	solution	solution	NOUN
bjp-33625	82	11	of	of	ADP
bjp-33625	82	12	step	step	NOUN
bjp-33625	82	13	2	2	NUM
bjp-33625	82	14	(	(	PUNCT
bjp-33625	82	15	0.01	0.01	NUM
bjp-33625	82	16	m	m	NOUN
bjp-33625	82	17	)	)	PUNCT
bjp-33625	82	18	and	and	CCONJ
bjp-33625	82	19	aromatic	aromatic	ADJ
bjp-33625	82	20	aldehyde	aldehyde	NOUN
bjp-33625	82	21	(	(	PUNCT
bjp-33625	82	22	0.01	0.01	NUM
bjp-33625	82	23	m	m	NOUN
bjp-33625	82	24	)	)	PUNCT
bjp-33625	82	25	in	in	ADP
bjp-33625	82	26	ethanol	ethanol	NOUN
bjp-33625	82	27	(	(	PUNCT
bjp-33625	82	28	20	20	NUM
bjp-33625	82	29	ml	ml	NOUN
bjp-33625	82	30	)	)	PUNCT
bjp-33625	82	31	was	be	AUX
bjp-33625	82	32	added	add	VERB
bjp-33625	82	33	into	into	ADP
bjp-33625	82	34	a	a	DET
bjp-33625	82	35	solution	solution	NOUN
bjp-33625	82	36	of	of	ADP
bjp-33625	82	37	sodium	sodium	NOUN
bjp-33625	82	38	hydroxide	hydroxide	NOUN
bjp-33625	82	39	(	(	PUNCT
bjp-33625	82	40	8	8	NUM
bjp-33625	82	41	ml	ml	NOUN
bjp-33625	82	42	,	,	PUNCT
bjp-33625	82	43	10	10	NUM
bjp-33625	82	44	%	%	NOUN
bjp-33625	82	45	solution	solution	NOUN
bjp-33625	82	46	)	)	PUNCT
bjp-33625	82	47	.	.	PUNCT
bjp-33625	83	1	the	the	DET
bjp-33625	83	2	reaction	reaction	NOUN
bjp-33625	83	3	mixture	mixture	NOUN
bjp-33625	83	4	was	be	AUX
bjp-33625	83	5	stirred	stir	VERB
bjp-33625	83	6	at	at	ADP
bjp-33625	83	7	room	room	NOUN
bjp-33625	83	8	temperature	temperature	NOUN
bjp-33625	83	9	over	over	ADP
bjp-33625	83	10	a	a	DET
bjp-33625	83	11	period	period	NOUN
bjp-33625	83	12	of	of	ADP
bjp-33625	83	13	24	24	NUM
bjp-33625	83	14	hours	hour	NOUN
bjp-33625	83	15	,	,	PUNCT
bjp-33625	83	16	diluted	dilute	VERB
bjp-33625	83	17	with	with	ADP
bjp-33625	83	18	water	water	NOUN
bjp-33625	83	19	(	(	PUNCT
bjp-33625	83	20	100	100	NUM
bjp-33625	83	21	ml	ml	NOUN
bjp-33625	83	22	)	)	PUNCT
bjp-33625	83	23	and	and	CCONJ
bjp-33625	83	24	acidified	acidify	VERB
bjp-33625	83	25	with	with	ADP
bjp-33625	83	26	concentrated	concentrate	VERB
bjp-33625	83	27	hcl	hcl	PROPN
bjp-33625	83	28	.	.	PUNCT
bjp-33625	84	1	the	the	DET
bjp-33625	84	2	product	product	NOUN
bjp-33625	84	3	obtained	obtain	VERB
bjp-33625	84	4	was	be	AUX
bjp-33625	84	5	filtered	filter	VERB
bjp-33625	84	6	,	,	PUNCT
bjp-33625	84	7	washed	wash	VERB
bjp-33625	84	8	with	with	ADP
bjp-33625	84	9	water	water	NOUN
bjp-33625	84	10	and	and	CCONJ
bjp-33625	84	11	recrystallized	recrystallize	VERB
bjp-33625	84	12	from	from	ADP
bjp-33625	84	13	ethanol	ethanol	NOUN
bjp-33625	84	14	(	(	PUNCT
bjp-33625	84	15	scheme	scheme	NOUN
bjp-33625	84	16	1	1	NUM
bjp-33625	84	17	)	)	PUNCT
bjp-33625	84	18	.	.	PUNCT
bjp-33625	85	1	scheme	scheme	NOUN
bjp-33625	85	2	2	2	NUM
bjp-33625	85	3	step	step	NOUN
bjp-33625	85	4	1	1	NUM
bjp-33625	85	5	:	:	PUNCT
bjp-33625	85	6	synthesis	synthesis	NOUN
bjp-33625	85	7	of	of	ADP
bjp-33625	85	8	2	2	NUM
bjp-33625	85	9	-	-	PUNCT
bjp-33625	85	10	methyl-5	methyl-5	NOUN
bjp-33625	85	11	-	-	PUNCT
bjp-33625	85	12	nitro-1	nitro-1	NUM
bjp-33625	85	13	-	-	PUNCT
bjp-33625	85	14	imidazoethyl	imidazoethyl	NOUN
bjp-33625	85	15	acetate	acetate	NOUN
bjp-33625	85	16	(	(	PUNCT
bjp-33625	85	17	havaldar	havaldar	PROPN
bjp-33625	85	18	and	and	CCONJ
bjp-33625	85	19	patil	patil	PROPN
bjp-33625	85	20	,	,	PUNCT
bjp-33625	85	21	2008	2008	NUM
bjp-33625	85	22	)	)	PUNCT
bjp-33625	85	23	a	a	DET
bjp-33625	85	24	mixture	mixture	NOUN
bjp-33625	85	25	of	of	ADP
bjp-33625	85	26	2	2	NUM
bjp-33625	85	27	-	-	PUNCT
bjp-33625	85	28	methyl-5	methyl-5	NOUN
bjp-33625	85	29	-	-	PUNCT
bjp-33625	85	30	nitro	nitro	NOUN
bjp-33625	85	31	-	-	PUNCT
bjp-33625	85	32	imidazole	imidazole	NOUN
bjp-33625	85	33	(	(	PUNCT
bjp-33625	85	34	0.01	0.01	NUM
bjp-33625	85	35	m	m	NOUN
bjp-33625	85	36	)	)	PUNCT
bjp-33625	85	37	,	,	PUNCT
bjp-33625	85	38	ethyl	ethyl	PROPN
bjp-33625	85	39	chloroacetate	chloroacetate	NOUN
bjp-33625	85	40	(	(	PUNCT
bjp-33625	85	41	12	12	NUM
bjp-33625	85	42	ml	ml	NOUN
bjp-33625	85	43	)	)	PUNCT
bjp-33625	85	44	and	and	CCONJ
bjp-33625	85	45	potassium	potassium	NOUN
bjp-33625	85	46	carbonate	carbonate	NOUN
bjp-33625	85	47	(	(	PUNCT
bjp-33625	85	48	0.05	0.05	NUM
bjp-33625	85	49	ml	ml	NOUN
bjp-33625	85	50	)	)	PUNCT
bjp-33625	85	51	in	in	ADP
bjp-33625	85	52	dry	dry	ADJ
bjp-33625	85	53	acetone	acetone	NOUN
bjp-33625	85	54	were	be	AUX
bjp-33625	85	55	refluxed	refluxe	VERB
bjp-33625	85	56	for	for	ADP
bjp-33625	85	57	50	50	NUM
bjp-33625	85	58	hours	hour	NOUN
bjp-33625	85	59	.	.	PUNCT
bjp-33625	86	1	the	the	DET
bjp-33625	86	2	reaction	reaction	NOUN
bjp-33625	86	3	mixture	mixture	NOUN
bjp-33625	86	4	was	be	AUX
bjp-33625	86	5	filtered	filter	VERB
bjp-33625	86	6	hot	hot	ADJ
bjp-33625	86	7	,	,	PUNCT
bjp-33625	86	8	and	and	CCONJ
bjp-33625	86	9	the	the	DET
bjp-33625	86	10	solvent	solvent	NOUN
bjp-33625	86	11	was	be	AUX
bjp-33625	86	12	distilled	distil	VERB
bjp-33625	86	13	off	off	ADP
bjp-33625	86	14	from	from	ADP
bjp-33625	86	15	the	the	DET
bjp-33625	86	16	filtrate	filtrate	NOUN
bjp-33625	86	17	.	.	PUNCT
bjp-33625	87	1	the	the	DET
bjp-33625	87	2	crude	crude	ADJ
bjp-33625	87	3	ester	ester	NOUN
bjp-33625	87	4	thus	thus	ADV
bjp-33625	87	5	obtained	obtain	VERB
bjp-33625	87	6	was	be	AUX
bjp-33625	87	7	purified	purify	VERB
bjp-33625	87	8	by	by	ADP
bjp-33625	87	9	recrystallization	recrystallization	NOUN
bjp-33625	87	10	using	use	VERB
bjp-33625	87	11	methanol	methanol	NOUN
bjp-33625	87	12	.	.	PUNCT
bjp-33625	88	1	step	step	NOUN
bjp-33625	88	2	2	2	NUM
bjp-33625	88	3	:	:	PUNCT
bjp-33625	88	4	synthesis	synthesis	NOUN
bjp-33625	88	5	of	of	ADP
bjp-33625	88	6	2	2	NUM
bjp-33625	88	7	-	-	PUNCT
bjp-33625	88	8	methyl-5	methyl-5	NOUN
bjp-33625	88	9	-	-	PUNCT
bjp-33625	88	10	nitro-1	nitro-1	NUM
bjp-33625	88	11	-	-	PUNCT
bjp-33625	88	12	imidazo	imidazo	NOUN
bjp-33625	88	13	acethydrazide	acethydrazide	VERB
bjp-33625	88	14	a	a	DET
bjp-33625	88	15	mixture	mixture	NOUN
bjp-33625	88	16	of	of	ADP
bjp-33625	88	17	2	2	NUM
bjp-33625	88	18	-	-	PUNCT
bjp-33625	88	19	methyl-5	methyl-5	NUM
bjp-33625	88	20	nitro-1	nitro-1	NUM
bjp-33625	88	21	-	-	PUNCT
bjp-33625	88	22	imidazoethyl	imidazoethyl	NOUN
bjp-33625	88	23	acetates	acetate	NOUN
bjp-33625	88	24	obtained	obtain	VERB
bjp-33625	88	25	from	from	ADP
bjp-33625	88	26	step-1	step-1	PROPN
bjp-33625	88	27	and	and	CCONJ
bjp-33625	88	28	hydrazine	hydrazine	NOUN
bjp-33625	88	29	hydrate	hydrate	NOUN
bjp-33625	88	30	(	(	PUNCT
bjp-33625	88	31	0.1	0.1	NUM
bjp-33625	88	32	m	m	NOUN
bjp-33625	88	33	)	)	PUNCT
bjp-33625	88	34	in	in	ADP
bjp-33625	88	35	ethanol	ethanol	NOUN
bjp-33625	88	36	(	(	PUNCT
bjp-33625	88	37	50	50	NUM
bjp-33625	88	38	ml	ml	NOUN
bjp-33625	88	39	)	)	PUNCT
bjp-33625	88	40	was	be	AUX
bjp-33625	88	41	refluxed	refluxe	VERB
bjp-33625	88	42	for	for	ADP
bjp-33625	88	43	8	8	NUM
bjp-33625	88	44	hours	hour	NOUN
bjp-33625	88	45	.	.	PUNCT
bjp-33625	89	1	the	the	DET
bjp-33625	89	2	solution	solution	NOUN
bjp-33625	89	3	on	on	ADP
bjp-33625	89	4	cooling	cool	VERB
bjp-33625	89	5	gave	give	VERB
bjp-33625	89	6	the	the	DET
bjp-33625	89	7	solid	solid	ADJ
bjp-33625	89	8	mass	mass	NOUN
bjp-33625	89	9	of	of	ADP
bjp-33625	89	10	hydrazine	hydrazine	NOUN
bjp-33625	89	11	,	,	PUNCT
bjp-33625	89	12	which	which	PRON
bjp-33625	89	13	was	be	AUX
bjp-33625	89	14	collected	collect	VERB
bjp-33625	89	15	by	by	ADP
bjp-33625	89	16	filtration	filtration	NOUN
bjp-33625	89	17	and	and	CCONJ
bjp-33625	89	18	recrystallized	recrystallize	VERB
bjp-33625	89	19	from	from	ADP
bjp-33625	89	20	the	the	DET
bjp-33625	89	21	ethanol	ethanol	NOUN
bjp-33625	89	22	(	(	PUNCT
bjp-33625	89	23	scheme	scheme	NOUN
bjp-33625	89	24	2	2	NUM
bjp-33625	89	25	)	)	PUNCT
bjp-33625	89	26	.	.	PUNCT
bjp-33625	90	1	scheme	scheme	VERB
bjp-33625	90	2	3	3	NUM
bjp-33625	90	3	synthesis	synthesis	NOUN
bjp-33625	90	4	of	of	ADP
bjp-33625	90	5	1-[3-(1h	1-[3-(1h	PROPN
bjp-33625	90	6	-	-	PUNCT
bjp-33625	90	7	benzoimidazol-2	benzoimidazol-2	NUM
bjp-33625	90	8	-	-	PUNCT
bjp-33625	90	9	yl)-4,5	yl)-4,5	NOUN
bjp-33625	90	10	-	-	PUNCT
bjp-33625	90	11	dihydropyrazol-1	dihydropyrazol-1	NUM
bjp-33625	90	12	-	-	PUNCT
bjp-33625	90	13	yl]-2-(2	yl]-2-(2	NOUN
bjp-33625	90	14	-	-	PUNCT
bjp-33625	90	15	methyl-5	methyl-5	NOUN
bjp-33625	90	16	-	-	PUNCT
bjp-33625	90	17	nitro	nitro	NOUN
bjp-33625	90	18	-	-	PUNCT
bjp-33625	90	19	imidazol-1	imidazol-1	NUM
bjp-33625	90	20	-	-	PUNCT
bjp-33625	90	21	yl)ethanone	yl)ethanone	NOUN
bjp-33625	90	22	derivatives	derivative	NOUN
bjp-33625	90	23	(	(	PUNCT
bjp-33625	90	24	sharma	sharma	PROPN
bjp-33625	90	25	et	et	PROPN
bjp-33625	90	26	al	al	PROPN
bjp-33625	90	27	.	.	PROPN
bjp-33625	90	28	,	,	PUNCT
bjp-33625	90	29	2014	2014	NUM
bjp-33625	90	30	)	)	PUNCT
bjp-33625	90	31	a	a	DET
bjp-33625	90	32	mixture	mixture	NOUN
bjp-33625	90	33	of	of	ADP
bjp-33625	90	34	various	various	ADJ
bjp-33625	90	35	derivatives	derivative	NOUN
bjp-33625	90	36	of	of	ADP
bjp-33625	90	37	synthesized	synthesize	VERB
bjp-33625	90	38	chalcones	chalcone	NOUN
bjp-33625	90	39	(	(	PUNCT
bjp-33625	90	40	0.01	0.01	NUM
bjp-33625	90	41	m	m	NOUN
bjp-33625	90	42	)	)	PUNCT
bjp-33625	90	43	and	and	CCONJ
bjp-33625	90	44	product	product	NOUN
bjp-33625	90	45	obtained	obtain	VERB
bjp-33625	90	46	from	from	ADP
bjp-33625	90	47	the	the	DET
bjp-33625	90	48	step	step	NOUN
bjp-33625	90	49	2	2	NUM
bjp-33625	90	50	of	of	ADP
bjp-33625	90	51	scheme	scheme	NOUN
bjp-33625	90	52	2	2	NUM
bjp-33625	90	53	(	(	PUNCT
bjp-33625	90	54	0.02	0.02	NUM
bjp-33625	90	55	m	m	NOUN
bjp-33625	90	56	)	)	PUNCT
bjp-33625	90	57	in	in	ADP
bjp-33625	90	58	25	25	NUM
bjp-33625	90	59	ml	ml	NOUN
bjp-33625	90	60	of	of	ADP
bjp-33625	90	61	ethanol	ethanol	NOUN
bjp-33625	90	62	and	and	CCONJ
bjp-33625	90	63	0.01	0.01	NUM
bjp-33625	90	64	ml	ml	NOUN
bjp-33625	90	65	of	of	ADP
bjp-33625	90	66	piperidine	piperidine	NOUN
bjp-33625	90	67	were	be	AUX
bjp-33625	90	68	added	add	VERB
bjp-33625	90	69	and	and	CCONJ
bjp-33625	90	70	refluxed	refluxe	VERB
bjp-33625	90	71	for	for	ADP
bjp-33625	90	72	6	6	NUM
bjp-33625	90	73	hours	hour	NOUN
bjp-33625	90	74	.	.	PUNCT
bjp-33625	91	1	excess	excess	ADJ
bjp-33625	91	2	nh2	nh2	PROPN
bjp-33625	91	3	nh2	nh2	PROPN
bjp-33625	91	4	+	+	CCONJ
bjp-33625	91	5	ch	ch	PROPN
bjp-33625	91	6	ch3	ch3	PROPN
bjp-33625	91	7	coohho	coohho	PROPN
bjp-33625	91	8	o	o	ADJ
bjp-33625	91	9	-	-	ADJ
bjp-33625	91	10	phenylene	phenylene	ADJ
bjp-33625	91	11	diamine	diamine	NOUN
bjp-33625	91	12	lactic	lactic	NOUN
bjp-33625	91	13	acid	acid	NOUN
bjp-33625	92	1	n	n	CCONJ
bjp-33625	92	2	h	h	NOUN
bjp-33625	92	3	n	n	PRON
bjp-33625	92	4	ch3	ch3	PROPN
bjp-33625	93	1	oh	oh	INTJ
bjp-33625	93	2	n	n	ADV
bjp-33625	93	3	h	h	NOUN
bjp-33625	93	4	n	n	X
bjp-33625	93	5	ch3	ch3	PROPN
bjp-33625	93	6	on	on	ADP
bjp-33625	93	7	h	h	PROPN
bjp-33625	93	8	n	n	PROPN
bjp-33625	93	9	ch	ch	NOUN
bjp-33625	93	10	o	o	NOUN
bjp-33625	93	11	ch	ch	NOUN
bjp-33625	93	12	r	r	PROPN
bjp-33625	93	13	ok2cr2o7	ok2cr2o7	SYM
bjp-33625	93	14	naoh	naoh	NOUN
bjp-33625	93	15	r	r	PROPN
bjp-33625	93	16	-	-	PUNCT
bjp-33625	93	17	cho	cho	NOUN
bjp-33625	93	18	scheme	scheme	NOUN
bjp-33625	93	19	1	1	NUM
bjp-33625	93	20	:	:	PUNCT
bjp-33625	93	21	synthesis	synthesis	NOUN
bjp-33625	93	22	of	of	ADP
bjp-33625	93	23	benzimidazole	benzimidazole	PROPN
bjp-33625	93	24	chalcones	chalcone	NOUN
bjp-33625	93	25	r=	r=	ADJ
bjp-33625	93	26	2	2	NUM
bjp-33625	93	27	-	-	PUNCT
bjp-33625	93	28	cl	cl	NOUN
bjp-33625	93	29	(	(	PUNCT
bjp-33625	93	30	c6h5	c6h5	NOUN
bjp-33625	93	31	)	)	PUNCT
bjp-33625	93	32	,	,	PUNCT
bjp-33625	93	33	4	4	NUM
bjp-33625	93	34	-	-	SYM
bjp-33625	93	35	f	f	X
bjp-33625	93	36	(	(	PUNCT
bjp-33625	93	37	c6h5	c6h5	PROPN
bjp-33625	93	38	)	)	PUNCT
bjp-33625	93	39	,	,	PUNCT
bjp-33625	93	40	4	4	NUM
bjp-33625	93	41	-	-	SYM
bjp-33625	93	42	oh	oh	INTJ
bjp-33625	93	43	(	(	PUNCT
bjp-33625	93	44	c6h5),-ch	c6h5),-ch	PROPN
bjp-33625	93	45	=	=	PROPN
bjp-33625	93	46	ch	ch	NOUN
bjp-33625	93	47	-	-	PUNCT
bjp-33625	93	48	c6h5	c6h5	NOUN
bjp-33625	93	49	scheme	scheme	NOUN
bjp-33625	93	50	2	2	NUM
bjp-33625	93	51	:	:	PUNCT
bjp-33625	93	52	synthesis	synthesis	NOUN
bjp-33625	93	53	of	of	ADP
bjp-33625	93	54	2	2	NUM
bjp-33625	93	55	-	-	PUNCT
bjp-33625	93	56	methyl5	methyl5	NOUN
bjp-33625	93	57	-	-	PUNCT
bjp-33625	93	58	nitro-1	nitro-1	NOUN
bjp-33625	93	59	-	-	PUNCT
bjp-33625	93	60	imidazo	imidazo	NOUN
bjp-33625	93	61	acethydrazide	acethydrazide	NOUN
bjp-33625	93	62	n	n	PRON
bjp-33625	93	63	no2n	no2n	PROPN
bjp-33625	93	64	ch3	ch3	PROPN
bjp-33625	93	65	h	h	NOUN
bjp-33625	94	1	+	+	CCONJ
bjp-33625	94	2	cl	cl	NOUN
bjp-33625	94	3	ch2	ch2	NOUN
bjp-33625	94	4	c	c	NOUN
bjp-33625	95	1	o	o	X
bjp-33625	96	1	o	o	X
bjp-33625	96	2	c2h5	c2h5	NOUN
bjp-33625	96	3	n	n	CCONJ
bjp-33625	96	4	no2n	no2n	PROPN
bjp-33625	96	5	ch3	ch3	PROPN
bjp-33625	96	6	ch2cooc2h5	ch2cooc2h5	VERB
bjp-33625	96	7	n	n	PROPN
bjp-33625	96	8	no2n	no2n	PROPN
bjp-33625	96	9	ch3	ch3	PROPN
bjp-33625	96	10	ch2conhnh2	ch2conhnh2	NOUN
bjp-33625	96	11	2	2	NUM
bjp-33625	96	12	-	-	PUNCT
bjp-33625	96	13	methyl-5	methyl-5	NOUN
bjp-33625	96	14	-	-	PUNCT
bjp-33625	96	15	nitro	nitro	NOUN
bjp-33625	96	16	-	-	PUNCT
bjp-33625	96	17	imidazole	imidazole	NOUN
bjp-33625	96	18	ethyl	ethyl	PROPN
bjp-33625	96	19	chloroacetate	chloroacetate	NOUN
bjp-33625	96	20	n2h4.h2o	n2h4.h2o	NOUN
bjp-33625	96	21	/	/	SYM
bjp-33625	96	22	c2h5oh	c2h5oh	PROPN
bjp-33625	96	23	bangladesh	bangladesh	NOUN
bjp-33625	96	24	j	j	PROPN
bjp-33625	96	25	pharmacol	pharmacol	PROPN
bjp-33625	96	26	2018	2018	NUM
bjp-33625	96	27	;	;	PUNCT
bjp-33625	96	28	13	13	NUM
bjp-33625	96	29	:	:	SYM
bjp-33625	96	30	23	23	NUM
bjp-33625	96	31	-	-	SYM
bjp-33625	96	32	29	29	NUM
bjp-33625	96	33	25	25	NUM
bjp-33625	96	34	of	of	ADP
bjp-33625	96	35	ethanol	ethanol	NOUN
bjp-33625	96	36	was	be	AUX
bjp-33625	96	37	distilled	distil	VERB
bjp-33625	96	38	and	and	CCONJ
bjp-33625	96	39	crystalline	crystalline	ADJ
bjp-33625	96	40	solid	solid	ADJ
bjp-33625	96	41	products	product	NOUN
bjp-33625	96	42	obtained	obtain	VERB
bjp-33625	96	43	were	be	AUX
bjp-33625	96	44	filtered	filter	VERB
bjp-33625	96	45	and	and	CCONJ
bjp-33625	96	46	recrystallized	recrystallize	VERB
bjp-33625	96	47	from	from	ADP
bjp-33625	96	48	the	the	DET
bjp-33625	96	49	ethanol	ethanol	NOUN
bjp-33625	96	50	.	.	PUNCT
bjp-33625	97	1	the	the	DET
bjp-33625	97	2	purity	purity	NOUN
bjp-33625	97	3	of	of	ADP
bjp-33625	97	4	the	the	DET
bjp-33625	97	5	derivatives	derivative	NOUN
bjp-33625	97	6	was	be	AUX
bjp-33625	97	7	confirmed	confirm	VERB
bjp-33625	97	8	by	by	ADP
bjp-33625	97	9	a	a	DET
bjp-33625	97	10	single	single	ADJ
bjp-33625	97	11	spot	spot	NOUN
bjp-33625	97	12	on	on	ADP
bjp-33625	97	13	the	the	DET
bjp-33625	97	14	tlc	tlc	NOUN
bjp-33625	97	15	plate	plate	NOUN
bjp-33625	97	16	(	(	PUNCT
bjp-33625	97	17	scheme	scheme	NOUN
bjp-33625	97	18	3	3	NUM
bjp-33625	97	19	)	)	PUNCT
bjp-33625	97	20	.	.	PUNCT
bjp-33625	98	1	antimalarial	antimalarial	NOUN
bjp-33625	98	2	screening	screen	VERB
bjp-33625	98	3	the	the	DET
bjp-33625	98	4	in	in	ADV
bjp-33625	98	5	vitro	vitro	X
bjp-33625	98	6	antimalarial	antimalarial	ADJ
bjp-33625	98	7	assay	assay	NOUN
bjp-33625	98	8	was	be	AUX
bjp-33625	98	9	carried	carry	VERB
bjp-33625	98	10	out	out	ADP
bjp-33625	98	11	in	in	ADP
bjp-33625	98	12	96well	96well	PROPN
bjp-33625	98	13	microliter	microliter	NOUN
bjp-33625	98	14	plates	plate	NOUN
bjp-33625	98	15	(	(	PUNCT
bjp-33625	98	16	lee	lee	PROPN
bjp-33625	98	17	et	et	PROPN
bjp-33625	98	18	al	al	PROPN
bjp-33625	98	19	.	.	PROPN
bjp-33625	98	20	,	,	PUNCT
bjp-33625	98	21	2002	2002	NUM
bjp-33625	98	22	)	)	PUNCT
bjp-33625	98	23	.	.	PUNCT
bjp-33625	99	1	the	the	DET
bjp-33625	99	2	cultures	culture	NOUN
bjp-33625	99	3	of	of	ADP
bjp-33625	99	4	plasmodium	plasmodium	NOUN
bjp-33625	99	5	falciparum	falciparum	NOUN
bjp-33625	99	6	rkl-2	rkl-2	PUNCT
bjp-33625	99	7	strain	strain	NOUN
bjp-33625	99	8	were	be	AUX
bjp-33625	99	9	maintained	maintain	VERB
bjp-33625	99	10	in	in	ADP
bjp-33625	99	11	medium	medium	ADJ
bjp-33625	99	12	rpmi	rpmi	NOUN
bjp-33625	99	13	1640	1640	NUM
bjp-33625	99	14	supplemented	supplement	VERB
bjp-33625	99	15	with	with	ADP
bjp-33625	99	16	25	25	NUM
bjp-33625	99	17	mm	mm	PROPN
bjp-33625	99	18	hepes	hepe	NOUN
bjp-33625	99	19	,	,	PUNCT
bjp-33625	99	20	1	1	NUM
bjp-33625	99	21	%	%	NOUN
bjp-33625	99	22	d	d	NOUN
bjp-33625	99	23	-	-	NOUN
bjp-33625	99	24	glucose	glucose	NOUN
bjp-33625	99	25	,	,	PUNCT
bjp-33625	99	26	0.2	0.2	NUM
bjp-33625	99	27	%	%	NOUN
bjp-33625	99	28	sodium	sodium	NOUN
bjp-33625	99	29	bicarbonate	bicarbonate	NOUN
bjp-33625	99	30	and	and	CCONJ
bjp-33625	99	31	10	10	NUM
bjp-33625	99	32	%	%	NOUN
bjp-33625	99	33	heat	heat	NOUN
bjp-33625	99	34	inactivated	inactivate	VERB
bjp-33625	99	35	human	human	ADJ
bjp-33625	99	36	serum	serum	NOUN
bjp-33625	99	37	.	.	PUNCT
bjp-33625	100	1	180	180	NUM
bjp-33625	100	2	ml	ml	NOUN
bjp-33625	100	3	of	of	ADP
bjp-33625	100	4	1	1	NUM
bjp-33625	100	5	%	%	NOUN
bjp-33625	100	6	d	d	NOUN
bjp-33625	100	7	-	-	NOUN
bjp-33625	100	8	sorbitol	sorbitol	NOUN
bjp-33625	100	9	synchronized	synchronize	VERB
bjp-33625	100	10	ring	ring	NOUN
bjp-33625	100	11	stage	stage	NOUN
bjp-33625	100	12	parasitemia	parasitemia	NOUN
bjp-33625	100	13	in	in	ADP
bjp-33625	100	14	3	3	NUM
bjp-33625	100	15	%	%	NOUN
bjp-33625	100	16	hematocrit	hematocrit	NOUN
bjp-33625	100	17	in	in	ADP
bjp-33625	100	18	a	a	DET
bjp-33625	100	19	total	total	ADJ
bjp-33625	100	20	volume	volume	NOUN
bjp-33625	100	21	of	of	ADP
bjp-33625	100	22	200	200	NUM
bjp-33625	100	23	µl	µl	NOUN
bjp-33625	100	24	of	of	ADP
bjp-33625	100	25	medium	medium	ADJ
bjp-33625	100	26	rpmi-1640	rpmi-1640	NOUN
bjp-33625	100	27	was	be	AUX
bjp-33625	100	28	assessed	assess	VERB
bjp-33625	100	29	after	after	ADP
bjp-33625	100	30	converting	convert	VERB
bjp-33625	100	31	to	to	ADP
bjp-33625	100	32	final	final	ADJ
bjp-33625	100	33	dose	dose	NOUN
bjp-33625	100	34	.	.	PUNCT
bjp-33625	101	1	a	a	DET
bjp-33625	101	2	stock	stock	NOUN
bjp-33625	101	3	solution	solution	NOUN
bjp-33625	101	4	of	of	ADP
bjp-33625	101	5	5	5	NUM
bjp-33625	101	6	mg	mg	NUM
bjp-33625	101	7	/	/	SYM
bjp-33625	101	8	ml	ml	PROPN
bjp-33625	101	9	of	of	ADP
bjp-33625	101	10	each	each	PRON
bjp-33625	101	11	of	of	ADP
bjp-33625	101	12	the	the	DET
bjp-33625	101	13	test	test	NOUN
bjp-33625	101	14	samples	sample	NOUN
bjp-33625	101	15	was	be	AUX
bjp-33625	101	16	prepared	prepare	VERB
bjp-33625	101	17	in	in	ADP
bjp-33625	101	18	dmso	dmso	NOUN
bjp-33625	101	19	,	,	PUNCT
bjp-33625	101	20	and	and	CCONJ
bjp-33625	101	21	subsequent	subsequent	ADJ
bjp-33625	101	22	dilutions	dilution	NOUN
bjp-33625	101	23	were	be	AUX
bjp-33625	101	24	prepared	prepare	VERB
bjp-33625	101	25	with	with	ADP
bjp-33625	101	26	culture	culture	NOUN
bjp-33625	101	27	medium	medium	NOUN
bjp-33625	101	28	to	to	PART
bjp-33625	101	29	obtain	obtain	VERB
bjp-33625	101	30	5	5	NUM
bjp-33625	101	31	and	and	CCONJ
bjp-33625	101	32	50	50	NUM
bjp-33625	101	33	mg	mg	NUM
bjp-33625	101	34	/	/	SYM
bjp-33625	101	35	ml	ml	NOUN
bjp-33625	101	36	.	.	PUNCT
bjp-33625	102	1	the	the	DET
bjp-33625	102	2	test	test	NOUN
bjp-33625	102	3	plates	plate	NOUN
bjp-33625	102	4	,	,	PUNCT
bjp-33625	102	5	as	as	ADV
bjp-33625	102	6	well	well	ADV
bjp-33625	102	7	as	as	ADP
bjp-33625	102	8	the	the	DET
bjp-33625	102	9	positive	positive	ADJ
bjp-33625	102	10	and	and	CCONJ
bjp-33625	102	11	negative	negative	ADJ
bjp-33625	102	12	control	control	NOUN
bjp-33625	102	13	(	(	PUNCT
bjp-33625	102	14	chloroquine	chloroquine	NOUN
bjp-33625	102	15	and	and	CCONJ
bjp-33625	102	16	without	without	ADP
bjp-33625	102	17	sample	sample	NOUN
bjp-33625	102	18	respectively	respectively	ADV
bjp-33625	102	19	)	)	PUNCT
bjp-33625	102	20	,	,	PUNCT
bjp-33625	102	21	were	be	AUX
bjp-33625	102	22	incubated	incubate	VERB
bjp-33625	102	23	at	at	ADP
bjp-33625	102	24	37	37	NUM
bjp-33625	102	25	°	°	ADP
bjp-33625	102	26	c	c	NOUN
bjp-33625	102	27	for	for	ADP
bjp-33625	102	28	40	40	NUM
bjp-33625	102	29	hours	hour	NOUN
bjp-33625	102	30	after	after	ADP
bjp-33625	102	31	treating	treat	VERB
bjp-33625	102	32	with	with	ADP
bjp-33625	102	33	5	5	NUM
bjp-33625	102	34	%	%	NOUN
bjp-33625	102	35	co2	co2	NOUN
bjp-33625	102	36	.	.	PUNCT
bjp-33625	103	1	results	result	VERB
bjp-33625	103	2	characterization	characterization	NOUN
bjp-33625	103	3	of	of	ADP
bjp-33625	103	4	synthesized	synthesize	VERB
bjp-33625	103	5	compounds	compound	NOUN
bjp-33625	103	6	1-{3-(1h	1-{3-(1h	NUM
bjp-33625	103	7	-	-	PUNCT
bjp-33625	103	8	benzoimidazole-2	benzoimidazole-2	PROPN
bjp-33625	103	9	-	-	PUNCT
bjp-33625	103	10	yl)-5-(2	yl)-5-(2	PROPN
bjp-33625	103	11	-	-	PUNCT
bjp-33625	103	12	chlorophenyl)-4,5dihydro	chlorophenyl)-4,5dihydro	NOUN
bjp-33625	103	13	-	-	PUNCT
bjp-33625	103	14	pyrazol-1	pyrazol-1	NUM
bjp-33625	103	15	-	-	PUNCT
bjp-33625	103	16	yl]-2-(2	yl]-2-(2	NOUN
bjp-33625	103	17	-	-	PUNCT
bjp-33625	103	18	methyl-5	methyl-5	NOUN
bjp-33625	103	19	-	-	PUNCT
bjp-33625	103	20	nitro	nitro	NOUN
bjp-33625	103	21	-	-	PUNCT
bjp-33625	103	22	imidazol-1yl)-ethanone	imidazol-1yl)-ethanone	NUM
bjp-33625	103	23	(	(	PUNCT
bjp-33625	103	24	compound	compound	NOUN
bjp-33625	103	25	1	1	NUM
bjp-33625	103	26	):	):	PUNCT
bjp-33625	103	27	c22h18cln7o3	c22h18cln7o3	ADJ
bjp-33625	103	28	,	,	PUNCT
bjp-33625	103	29	yellow	yellow	ADJ
bjp-33625	103	30	crystals	crystal	NOUN
bjp-33625	103	31	,	,	PUNCT
bjp-33625	103	32	m=463.12	m=463.12	NOUN
bjp-33625	103	33	g	g	NOUN
bjp-33625	103	34	/	/	SYM
bjp-33625	103	35	mol	mol	PROPN
bjp-33625	103	36	,	,	PUNCT
bjp-33625	103	37	mp=145	mp=145	PROPN
bjp-33625	103	38	°	°	PROPN
bjp-33625	103	39	c	c	PROPN
bjp-33625	103	40	,	,	PUNCT
bjp-33625	103	41	ir	ir	PROPN
bjp-33625	103	42	(	(	PUNCT
bjp-33625	103	43	kbr	kbr	PROPN
bjp-33625	103	44	,	,	PUNCT
bjp-33625	103	45	cm-1	cm-1	NUM
bjp-33625	103	46	):	):	PUNCT
bjp-33625	103	47	1444.68	1444.68	NUM
bjp-33625	103	48	(	(	PUNCT
bjp-33625	103	49	c	c	X
bjp-33625	103	50	-	-	PUNCT
bjp-33625	103	51	c	c	NOUN
bjp-33625	103	52	)	)	PUNCT
bjp-33625	103	53	,	,	PUNCT
bjp-33625	103	54	1575.84	1575.84	NUM
bjp-33625	103	55	(	(	PUNCT
bjp-33625	103	56	n	n	CCONJ
bjp-33625	103	57	=	=	NOUN
bjp-33625	103	58	o	o	NOUN
bjp-33625	103	59	)	)	PUNCT
bjp-33625	103	60	,	,	PUNCT
bjp-33625	103	61	1631.78	1631.78	NUM
bjp-33625	103	62	(	(	PUNCT
bjp-33625	103	63	c	c	NOUN
bjp-33625	103	64	=	=	NOUN
bjp-33625	103	65	o	o	NOUN
bjp-33625	103	66	)	)	PUNCT
bjp-33625	103	67	,	,	PUNCT
bjp-33625	103	68	2947.239	2947.239	NUM
bjp-33625	103	69	(	(	PUNCT
bjp-33625	103	70	c	c	NOUN
bjp-33625	103	71	-	-	PUNCT
bjp-33625	103	72	h	h	NOUN
bjp-33625	103	73	)	)	PUNCT
bjp-33625	103	74	.	.	PUNCT
bjp-33625	104	1	1h	1h	NUM
bjp-33625	104	2	nmr(500mhz	nmr(500mhz	PROPN
bjp-33625	104	3	,	,	PUNCT
bjp-33625	104	4	meod	meod	NOUN
bjp-33625	104	5	,	,	PUNCT
bjp-33625	104	6	δ	δ	PROPN
bjp-33625	104	7	/	/	SYM
bjp-33625	104	8	ppm	ppm	PROPN
bjp-33625	104	9	,	,	PUNCT
bjp-33625	104	10	j	j	PROPN
bjp-33625	104	11	/	/	SYM
bjp-33625	104	12	hz	hz	PROPN
bjp-33625	104	13	):	):	PUNCT
bjp-33625	104	14	2.2	2.2	NUM
bjp-33625	104	15	(	(	PUNCT
bjp-33625	104	16	2h	2h	NUM
bjp-33625	104	17	,	,	PUNCT
bjp-33625	104	18	t	t	PROPN
bjp-33625	104	19	,	,	PUNCT
bjp-33625	104	20	j=5.0	j=5.0	NOUN
bjp-33625	104	21	,	,	PUNCT
bjp-33625	104	22	ch2	ch2	NOUN
bjp-33625	104	23	-	-	PUNCT
bjp-33625	104	24	pyrazoline	pyrazoline	NOUN
bjp-33625	104	25	)	)	PUNCT
bjp-33625	104	26	,	,	PUNCT
bjp-33625	104	27	2.435	2.435	NUM
bjp-33625	104	28	(	(	PUNCT
bjp-33625	104	29	3h	3h	NUM
bjp-33625	104	30	,	,	PUNCT
bjp-33625	104	31	s	s	X
bjp-33625	104	32	,	,	PUNCT
bjp-33625	104	33	-ch3	-ch3	ADJ
bjp-33625	104	34	)	)	PUNCT
bjp-33625	104	35	,	,	PUNCT
bjp-33625	104	36	4.5	4.5	NUM
bjp-33625	104	37	(	(	PUNCT
bjp-33625	104	38	2h	2h	NUM
bjp-33625	104	39	,	,	PUNCT
bjp-33625	104	40	s	s	X
bjp-33625	104	41	,	,	PUNCT
bjp-33625	104	42	-ch2	-ch2	NUM
bjp-33625	104	43	)	)	PUNCT
bjp-33625	104	44	,	,	PUNCT
bjp-33625	104	45	5.0(1h	5.0(1h	NUM
bjp-33625	104	46	,	,	PUNCT
bjp-33625	104	47	s	s	NOUN
bjp-33625	104	48	,	,	PUNCT
bjp-33625	104	49	-nh	-nh	ADJ
bjp-33625	104	50	)	)	PUNCT
bjp-33625	104	51	,	,	PUNCT
bjp-33625	104	52	7.45	7.45	NUM
bjp-33625	104	53	-	-	SYM
bjp-33625	104	54	7.68	7.68	NUM
bjp-33625	104	55	(	(	PUNCT
bjp-33625	104	56	9h	9h	NUM
bjp-33625	104	57	,	,	PUNCT
bjp-33625	104	58	m	m	NOUN
bjp-33625	104	59	,	,	PUNCT
bjp-33625	104	60	charomatic	charomatic	NOUN
bjp-33625	104	61	)	)	PUNCT
bjp-33625	104	62	.	.	PUNCT
bjp-33625	105	1	ms	ms	PROPN
bjp-33625	105	2	(	(	PUNCT
bjp-33625	105	3	esi	esi	PROPN
bjp-33625	105	4	):	):	PUNCT
bjp-33625	105	5	m	m	PROPN
bjp-33625	105	6	/	/	SYM
bjp-33625	105	7	z	z	PROPN
bjp-33625	105	8	465.6	465.6	NUM
bjp-33625	105	9	(	(	PUNCT
bjp-33625	105	10	m	m	PROPN
bjp-33625	105	11	+	+	ADJ
bjp-33625	105	12	2h)+	2h)+	NUM
bjp-33625	105	13	.	.	PUNCT
bjp-33625	106	1	1-[3-(1h	1-[3-(1h	NUM
bjp-33625	106	2	-	-	PUNCT
bjp-33625	106	3	benzoimidazol-2	benzoimidazol-2	PROPN
bjp-33625	106	4	-	-	PUNCT
bjp-33625	106	5	yl)-5-(4	yl)-5-(4	PROPN
bjp-33625	106	6	-	-	PUNCT
bjp-33625	106	7	fluoro	fluoro	NOUN
bjp-33625	106	8	-	-	PUNCT
bjp-33625	106	9	phenyl)-4	phenyl)-4	PROPN
bjp-33625	106	10	,	,	PUNCT
bjp-33625	106	11	5dihydro	5dihydro	PROPN
bjp-33625	106	12	-	-	PUNCT
bjp-33625	106	13	pyrazol-1	pyrazol-1	NUM
bjp-33625	106	14	-	-	PUNCT
bjp-33625	106	15	yl]-2-(2	yl]-2-(2	NOUN
bjp-33625	106	16	-	-	PUNCT
bjp-33625	106	17	methyl-5	methyl-5	NOUN
bjp-33625	106	18	-	-	PUNCT
bjp-33625	106	19	nitro	nitro	NOUN
bjp-33625	106	20	-	-	PUNCT
bjp-33625	106	21	imidazol-1yl)-ethanone	imidazol-1yl)-ethanone	NUM
bjp-33625	106	22	(	(	PUNCT
bjp-33625	106	23	compound	compound	NOUN
bjp-33625	106	24	2	2	NUM
bjp-33625	106	25	):	):	PUNCT
bjp-33625	106	26	c22h18fn7o3	c22h18fn7o3	ADJ
bjp-33625	106	27	,	,	PUNCT
bjp-33625	106	28	yellow	yellow	ADJ
bjp-33625	106	29	crystals	crystal	NOUN
bjp-33625	106	30	,	,	PUNCT
bjp-33625	106	31	m=447.15	m=447.15	NOUN
bjp-33625	106	32	g	g	PROPN
bjp-33625	106	33	/	/	SYM
bjp-33625	106	34	mol	mol	PROPN
bjp-33625	106	35	,	,	PUNCT
bjp-33625	106	36	mp=160	mp=160	PROPN
bjp-33625	106	37	°	°	PROPN
bjp-33625	106	38	c	c	PROPN
bjp-33625	106	39	,	,	PUNCT
bjp-33625	106	40	ir	ir	PROPN
bjp-33625	106	41	(	(	PUNCT
bjp-33625	106	42	kbr	kbr	PROPN
bjp-33625	106	43	,	,	PUNCT
bjp-33625	106	44	cm-1):1442.20	cm-1):1442.20	NUM
bjp-33625	106	45	(	(	PUNCT
bjp-33625	106	46	c	c	NOUN
bjp-33625	106	47	-	-	PUNCT
bjp-33625	106	48	c	c	NOUN
bjp-33625	106	49	)	)	PUNCT
bjp-33625	106	50	,	,	PUNCT
bjp-33625	106	51	1580.93(n	1580.93(n	NUM
bjp-33625	106	52	=	=	SYM
bjp-33625	106	53	o	o	NOUN
bjp-33625	106	54	)	)	PUNCT
bjp-33625	106	55	,	,	PUNCT
bjp-33625	106	56	1641.02(c	1641.02(c	NUM
bjp-33625	106	57	=	=	SYM
bjp-33625	106	58	o	o	NOUN
bjp-33625	106	59	)	)	PUNCT
bjp-33625	106	60	,	,	PUNCT
bjp-33625	106	61	2912.71(c	2912.71(c	NUM
bjp-33625	106	62	-	-	PUNCT
bjp-33625	106	63	h	h	NOUN
bjp-33625	106	64	)	)	PUNCT
bjp-33625	106	65	.	.	PUNCT
bjp-33625	107	1	1h	1h	NUM
bjp-33625	107	2	nmr	nmr	NOUN
bjp-33625	107	3	(	(	PUNCT
bjp-33625	107	4	500mhz	500mhz	NUM
bjp-33625	107	5	,	,	PUNCT
bjp-33625	107	6	meod	meod	NOUN
bjp-33625	107	7	,	,	PUNCT
bjp-33625	107	8	δ	δ	PROPN
bjp-33625	107	9	/	/	SYM
bjp-33625	107	10	ppm	ppm	PROPN
bjp-33625	107	11	,	,	PUNCT
bjp-33625	107	12	j	j	PROPN
bjp-33625	107	13	/	/	SYM
bjp-33625	107	14	hz):1.7(2h	hz):1.7(2h	PROPN
bjp-33625	107	15	,	,	PUNCT
bjp-33625	107	16	t	t	PROPN
bjp-33625	107	17	,	,	PUNCT
bjp-33625	107	18	j=7.5	j=7.5	NOUN
bjp-33625	107	19	,	,	PUNCT
bjp-33625	107	20	ch2	ch2	NOUN
bjp-33625	107	21	-	-	PUNCT
bjp-33625	107	22	pyrazoline	pyrazoline	NOUN
bjp-33625	107	23	)	)	PUNCT
bjp-33625	107	24	,	,	PUNCT
bjp-33625	107	25	2.29(3h	2.29(3h	NUM
bjp-33625	107	26	,	,	PUNCT
bjp-33625	107	27	s	s	X
bjp-33625	107	28	,	,	PUNCT
bjp-33625	107	29	-ch3	-ch3	ADJ
bjp-33625	107	30	)	)	PUNCT
bjp-33625	107	31	,	,	PUNCT
bjp-33625	107	32	4.5	4.5	NUM
bjp-33625	107	33	(	(	PUNCT
bjp-33625	107	34	2h	2h	NUM
bjp-33625	107	35	,	,	PUNCT
bjp-33625	107	36	s	s	X
bjp-33625	107	37	,	,	PUNCT
bjp-33625	107	38	-ch2	-ch2	NUM
bjp-33625	107	39	)	)	PUNCT
bjp-33625	107	40	,	,	PUNCT
bjp-33625	107	41	4.9	4.9	NUM
bjp-33625	107	42	(	(	PUNCT
bjp-33625	107	43	1h	1h	NUM
bjp-33625	107	44	,	,	PUNCT
bjp-33625	107	45	s	s	NOUN
bjp-33625	107	46	,	,	PUNCT
bjp-33625	107	47	-nh	-nh	ADJ
bjp-33625	107	48	)	)	PUNCT
bjp-33625	107	49	,	,	PUNCT
bjp-33625	107	50	7.390	7.390	NUM
bjp-33625	107	51	-	-	SYM
bjp-33625	107	52	8.044(9h	8.044(9h	NUM
bjp-33625	107	53	,	,	PUNCT
bjp-33625	107	54	m	m	PRON
bjp-33625	107	55	,	,	PUNCT
bjp-33625	107	56	ch	ch	NOUN
bjp-33625	107	57	-	-	PUNCT
bjp-33625	107	58	aromatic	aromatic	ADJ
bjp-33625	107	59	)	)	PUNCT
bjp-33625	107	60	.	.	PUNCT
bjp-33625	108	1	ms	ms	PROPN
bjp-33625	108	2	(	(	PUNCT
bjp-33625	108	3	esi	esi	PROPN
bjp-33625	108	4	):	):	PUNCT
bjp-33625	108	5	m	m	PROPN
bjp-33625	108	6	/	/	SYM
bjp-33625	108	7	z	z	PROPN
bjp-33625	108	8	448	448	NUM
bjp-33625	108	9	(	(	PUNCT
bjp-33625	108	10	m	m	PROPN
bjp-33625	108	11	+	+	X
bjp-33625	108	12	h)+	h)+	PROPN
bjp-33625	108	13	.	.	PUNCT
bjp-33625	109	1	1-[3-(1h	1-[3-(1h	NUM
bjp-33625	109	2	-	-	PUNCT
bjp-33625	109	3	benzoimidazol-2	benzoimidazol-2	PROPN
bjp-33625	109	4	-	-	PUNCT
bjp-33625	109	5	yl)-5-(4	yl)-5-(4	PROPN
bjp-33625	109	6	-	-	PUNCT
bjp-33625	109	7	hydroxy	hydroxy	VERB
bjp-33625	109	8	-	-	PUNCT
bjp-33625	109	9	phenyl)-4,5dihydro	phenyl)-4,5dihydro	NOUN
bjp-33625	109	10	-	-	PUNCT
bjp-33625	109	11	pyrazol-1	pyrazol-1	NUM
bjp-33625	109	12	-	-	PUNCT
bjp-33625	109	13	yl]-2-(2	yl]-2-(2	NOUN
bjp-33625	109	14	-	-	PUNCT
bjp-33625	109	15	methyl-5	methyl-5	NOUN
bjp-33625	109	16	-	-	PUNCT
bjp-33625	109	17	nitro	nitro	NOUN
bjp-33625	109	18	-	-	PUNCT
bjp-33625	109	19	imidazol-1yl)-ethanone	imidazol-1yl)-ethanone	NUM
bjp-33625	109	20	(	(	PUNCT
bjp-33625	109	21	compound	compound	NOUN
bjp-33625	109	22	3	3	NUM
bjp-33625	109	23	):	):	PUNCT
bjp-33625	109	24	c22h19n7o4	c22h19n7o4	PROPN
bjp-33625	109	25	,	,	PUNCT
bjp-33625	109	26	white	white	ADJ
bjp-33625	109	27	crystals	crystal	NOUN
bjp-33625	109	28	,	,	PUNCT
bjp-33625	109	29	m=445.15	m=445.15	NOUN
bjp-33625	109	30	g	g	PROPN
bjp-33625	109	31	/	/	SYM
bjp-33625	109	32	mol	mol	PROPN
bjp-33625	109	33	,	,	PUNCT
bjp-33625	109	34	mp=143	mp=143	PROPN
bjp-33625	109	35	°	°	PROPN
bjp-33625	109	36	c	c	PROPN
bjp-33625	109	37	,	,	PUNCT
bjp-33625	109	38	ir	ir	PROPN
bjp-33625	109	39	(	(	PUNCT
bjp-33625	109	40	kbr	kbr	PROPN
bjp-33625	109	41	,	,	PUNCT
bjp-33625	109	42	cm-1	cm-1	PROPN
bjp-33625	109	43	):	):	PUNCT
bjp-33625	109	44	1201.65(cc	1201.65(cc	NUM
bjp-33625	109	45	)	)	PUNCT
bjp-33625	109	46	,	,	PUNCT
bjp-33625	109	47	1579.7(n	1579.7(n	NUM
bjp-33625	109	48	=	=	SYM
bjp-33625	109	49	o	o	NOUN
bjp-33625	109	50	)	)	PUNCT
bjp-33625	109	51	,	,	PUNCT
bjp-33625	109	52	1647.21(c	1647.21(c	NUM
bjp-33625	109	53	=	=	NOUN
bjp-33625	109	54	o	o	NOUN
bjp-33625	109	55	)	)	PUNCT
bjp-33625	109	56	,	,	PUNCT
bjp-33625	109	57	3032.1(c	3032.1(c	PROPN
bjp-33625	109	58	-	-	NOUN
bjp-33625	109	59	h	h	NOUN
bjp-33625	109	60	)	)	PUNCT
bjp-33625	109	61	,	,	PUNCT
bjp-33625	109	62	3280.92(oh	3280.92(oh	NUM
bjp-33625	109	63	)	)	PUNCT
bjp-33625	109	64	.	.	PUNCT
bjp-33625	110	1	1h	1h	NUM
bjp-33625	110	2	nmr	nmr	NOUN
bjp-33625	110	3	(	(	PUNCT
bjp-33625	110	4	500mhz	500mhz	NUM
bjp-33625	110	5	,	,	PUNCT
bjp-33625	110	6	meod	meod	NOUN
bjp-33625	110	7	,	,	PUNCT
bjp-33625	110	8	δ	δ	PROPN
bjp-33625	110	9	/	/	SYM
bjp-33625	110	10	ppm	ppm	PROPN
bjp-33625	110	11	,	,	PUNCT
bjp-33625	110	12	j	j	PROPN
bjp-33625	110	13	/	/	SYM
bjp-33625	110	14	hz	hz	PROPN
bjp-33625	110	15	):	):	PUNCT
bjp-33625	110	16	2.1(2h	2.1(2h	NUM
bjp-33625	110	17	,	,	PUNCT
bjp-33625	110	18	t	t	PROPN
bjp-33625	110	19	,	,	PUNCT
bjp-33625	110	20	j=5.0	j=5.0	NOUN
bjp-33625	110	21	,	,	PUNCT
bjp-33625	110	22	ch2	ch2	NOUN
bjp-33625	110	23	-	-	PUNCT
bjp-33625	110	24	pyrazoline	pyrazoline	NOUN
bjp-33625	110	25	)	)	PUNCT
bjp-33625	110	26	,	,	PUNCT
bjp-33625	110	27	2.48(3h	2.48(3h	NOUN
bjp-33625	110	28	,	,	PUNCT
bjp-33625	110	29	s	s	X
bjp-33625	110	30	,	,	PUNCT
bjp-33625	110	31	-ch3	-ch3	ADJ
bjp-33625	110	32	)	)	PUNCT
bjp-33625	110	33	,	,	PUNCT
bjp-33625	110	34	3.33(1h	3.33(1h	NUM
bjp-33625	110	35	,	,	PUNCT
bjp-33625	110	36	s	s	X
bjp-33625	110	37	,	,	PUNCT
bjp-33625	110	38	oh	oh	INTJ
bjp-33625	110	39	)	)	PUNCT
bjp-33625	110	40	,	,	PUNCT
bjp-33625	110	41	6.3(2h	6.3(2h	NOUN
bjp-33625	110	42	,	,	PUNCT
bjp-33625	110	43	s	s	NOUN
bjp-33625	110	44	,	,	PUNCT
bjp-33625	110	45	-ch2	-ch2	NUM
bjp-33625	110	46	)	)	PUNCT
bjp-33625	110	47	,	,	PUNCT
bjp-33625	110	48	4.9(1h	4.9(1h	NUM
bjp-33625	110	49	,	,	PUNCT
bjp-33625	110	50	s	s	NOUN
bjp-33625	110	51	,	,	PUNCT
bjp-33625	110	52	-nh	-nh	ADJ
bjp-33625	110	53	)	)	PUNCT
bjp-33625	110	54	,	,	PUNCT
bjp-33625	110	55	6.652	6.652	NUM
bjp-33625	110	56	-	-	SYM
bjp-33625	110	57	8.113	8.113	NUM
bjp-33625	110	58	(	(	PUNCT
bjp-33625	110	59	9h	9h	NUM
bjp-33625	110	60	,	,	PUNCT
bjp-33625	110	61	m	m	PROPN
bjp-33625	110	62	,	,	PUNCT
bjp-33625	110	63	ch	ch	NOUN
bjp-33625	110	64	-	-	PUNCT
bjp-33625	110	65	aromatic	aromatic	ADJ
bjp-33625	110	66	)	)	PUNCT
bjp-33625	110	67	.	.	PUNCT
bjp-33625	111	1	ms	ms	PROPN
bjp-33625	111	2	(	(	PUNCT
bjp-33625	111	3	esi	esi	PROPN
bjp-33625	111	4	):	):	PUNCT
bjp-33625	111	5	m	m	PROPN
bjp-33625	111	6	/	/	SYM
bjp-33625	111	7	z	z	PROPN
bjp-33625	111	8	447	447	NUM
bjp-33625	111	9	(	(	PUNCT
bjp-33625	111	10	m	m	VERB
bjp-33625	111	11	+2h)+	+2h)+	ADJ
bjp-33625	111	12	.	.	PUNCT
bjp-33625	112	1	1-[3-(1h	1-[3-(1h	NUM
bjp-33625	112	2	-	-	PUNCT
bjp-33625	112	3	benzoimidazol-2	benzoimidazol-2	NUM
bjp-33625	112	4	-	-	PUNCT
bjp-33625	112	5	yl)-5	yl)-5	NOUN
bjp-33625	112	6	-	-	PUNCT
bjp-33625	112	7	styryl-4,5	styryl-4,5	VERB
bjp-33625	112	8	-	-	PUNCT
bjp-33625	112	9	dihydropyrazol-1	dihydropyrazol-1	NUM
bjp-33625	112	10	-	-	PUNCT
bjp-33625	112	11	yl]-2-(2	yl]-2-(2	NOUN
bjp-33625	112	12	-	-	PUNCT
bjp-33625	112	13	methyl-5	methyl-5	NOUN
bjp-33625	112	14	-	-	PUNCT
bjp-33625	112	15	nitro	nitro	NOUN
bjp-33625	112	16	-	-	PUNCT
bjp-33625	112	17	imidazol-1	imidazol-1	PRON
bjp-33625	112	18	-	-	PUNCT
bjp-33625	112	19	yl)ethanone	yl)ethanone	NOUN
bjp-33625	112	20	(	(	PUNCT
bjp-33625	112	21	compound	compound	NOUN
bjp-33625	112	22	4	4	NUM
bjp-33625	112	23	):	):	PUNCT
bjp-33625	112	24	c24h21n703	c24h21n703	ADJ
bjp-33625	112	25	,	,	PUNCT
bjp-33625	112	26	white	white	ADJ
bjp-33625	112	27	crystals	crystal	NOUN
bjp-33625	112	28	,	,	PUNCT
bjp-33625	112	29	m=455.17g	m=455.17g	PROPN
bjp-33625	112	30	/	/	SYM
bjp-33625	112	31	mol	mol	PROPN
bjp-33625	112	32	,	,	PUNCT
bjp-33625	112	33	mp=154	mp=154	VERB
bjp-33625	112	34	°	°	NOUN
bjp-33625	112	35	c	c	X
bjp-33625	112	36	,	,	PUNCT
bjp-33625	112	37	ir	ir	PROPN
bjp-33625	112	38	(	(	PUNCT
bjp-33625	112	39	kbr	kbr	PROPN
bjp-33625	112	40	,	,	PUNCT
bjp-33625	112	41	cm-1	cm-1	NUM
bjp-33625	112	42	):	):	PUNCT
bjp-33625	112	43	1212.04(cc	1212.04(cc	NUM
bjp-33625	112	44	)	)	PUNCT
bjp-33625	112	45	,	,	PUNCT
bjp-33625	112	46	1533.52(n	1533.52(n	NUM
bjp-33625	112	47	=	=	SYM
bjp-33625	112	48	o	o	NOUN
bjp-33625	112	49	)	)	PUNCT
bjp-33625	112	50	,	,	PUNCT
bjp-33625	112	51	1605.21(ch	1605.21(ch	NUM
bjp-33625	112	52	=	=	SYM
bjp-33625	112	53	ch-	ch-	PROPN
bjp-33625	112	54	)	)	PUNCT
bjp-33625	112	55	,	,	PUNCT
bjp-33625	112	56	1700.77(c	1700.77(c	NUM
bjp-33625	112	57	=	=	SYM
bjp-33625	112	58	o	o	NOUN
bjp-33625	112	59	)	)	PUNCT
bjp-33625	112	60	,	,	PUNCT
bjp-33625	112	61	3089.20(c	3089.20(c	NUM
bjp-33625	112	62	-	-	PUNCT
bjp-33625	112	63	h	h	NOUN
bjp-33625	112	64	)	)	PUNCT
bjp-33625	112	65	.	.	PUNCT
bjp-33625	113	1	1h	1h	NUM
bjp-33625	113	2	nmr	nmr	NOUN
bjp-33625	113	3	(	(	PUNCT
bjp-33625	113	4	500mhz	500mhz	NUM
bjp-33625	113	5	,	,	PUNCT
bjp-33625	113	6	meod	meod	NOUN
bjp-33625	113	7	,	,	PUNCT
bjp-33625	113	8	δ	δ	PROPN
bjp-33625	113	9	/	/	SYM
bjp-33625	113	10	ppm	ppm	PROPN
bjp-33625	113	11	,	,	PUNCT
bjp-33625	113	12	j/	j/	PROPN
bjp-33625	113	13	hz):1.4(2h	hz):1.4(2h	PROPN
bjp-33625	113	14	,	,	PUNCT
bjp-33625	113	15	t	t	PROPN
bjp-33625	113	16	,	,	PUNCT
bjp-33625	113	17	j=11.5	j=11.5	PROPN
bjp-33625	113	18	,	,	PUNCT
bjp-33625	113	19	ch2	ch2	NOUN
bjp-33625	113	20	-	-	PUNCT
bjp-33625	113	21	pyrazoline	pyrazoline	NOUN
bjp-33625	113	22	)	)	PUNCT
bjp-33625	113	23	,	,	PUNCT
bjp-33625	113	24	2.2(3h	2.2(3h	NUM
bjp-33625	113	25	,	,	PUNCT
bjp-33625	113	26	s	s	X
bjp-33625	113	27	,	,	PUNCT
bjp-33625	113	28	-ch3	-ch3	ADJ
bjp-33625	113	29	)	)	PUNCT
bjp-33625	113	30	,	,	PUNCT
bjp-33625	113	31	4.59(2h	4.59(2h	NOUN
bjp-33625	113	32	,	,	PUNCT
bjp-33625	113	33	s	s	NOUN
bjp-33625	113	34	,	,	PUNCT
bjp-33625	113	35	-ch2	-ch2	NUM
bjp-33625	113	36	)	)	PUNCT
bjp-33625	113	37	,	,	PUNCT
bjp-33625	113	38	4.87(1h	4.87(1h	NUM
bjp-33625	113	39	,	,	PUNCT
bjp-33625	113	40	s	s	PROPN
bjp-33625	113	41	,	,	PUNCT
bjp-33625	113	42	nh	nh	PROPN
bjp-33625	113	43	)	)	PUNCT
bjp-33625	113	44	,	,	PUNCT
bjp-33625	113	45	6.194	6.194	NUM
bjp-33625	113	46	-	-	SYM
bjp-33625	113	47	7.955	7.955	NUM
bjp-33625	113	48	(	(	PUNCT
bjp-33625	113	49	9h	9h	NUM
bjp-33625	113	50	,	,	PUNCT
bjp-33625	113	51	m	m	PROPN
bjp-33625	113	52	,	,	PUNCT
bjp-33625	113	53	ch	ch	NOUN
bjp-33625	113	54	-	-	PUNCT
bjp-33625	113	55	aromatic	aromatic	ADJ
bjp-33625	113	56	)	)	PUNCT
bjp-33625	113	57	.	.	PUNCT
bjp-33625	114	1	ms	ms	PROPN
bjp-33625	114	2	(	(	PUNCT
bjp-33625	114	3	esi	esi	PROPN
bjp-33625	114	4	):	):	PUNCT
bjp-33625	114	5	m	m	PROPN
bjp-33625	114	6	/	/	SYM
bjp-33625	114	7	z	z	PROPN
bjp-33625	114	8	455	455	NUM
bjp-33625	114	9	(	(	PUNCT
bjp-33625	114	10	m	m	PROPN
bjp-33625	114	11	)	)	PUNCT
bjp-33625	114	12	+	+	ADJ
bjp-33625	114	13	.	.	PUNCT
bjp-33625	114	14	pass	pass	VERB
bjp-33625	114	15	and	and	CCONJ
bjp-33625	114	16	swiss	swiss	ADJ
bjp-33625	114	17	adme	adme	NOUN
bjp-33625	114	18	the	the	DET
bjp-33625	114	19	results	result	NOUN
bjp-33625	114	20	obtained	obtain	VERB
bjp-33625	114	21	from	from	ADP
bjp-33625	114	22	in	in	ADP
bjp-33625	114	23	silico	silico	NOUN
bjp-33625	114	24	studies	study	NOUN
bjp-33625	114	25	clearly	clearly	ADV
bjp-33625	114	26	indicate	indicate	VERB
bjp-33625	114	27	compound	compound	NOUN
bjp-33625	114	28	code-3	code-3	NUM
bjp-33625	114	29	with	with	ADP
bjp-33625	114	30	hydroxy	hydroxy	NOUN
bjp-33625	114	31	substitution	substitution	NOUN
bjp-33625	114	32	is	be	AUX
bjp-33625	114	33	the	the	DET
bjp-33625	114	34	most	most	ADV
bjp-33625	114	35	druggable	druggable	ADJ
bjp-33625	114	36	substance	substance	NOUN
bjp-33625	114	37	with	with	ADP
bjp-33625	114	38	a	a	DET
bjp-33625	114	39	minimum	minimum	ADJ
bjp-33625	114	40	violation	violation	NOUN
bjp-33625	114	41	from	from	ADP
bjp-33625	114	42	any	any	PRON
bjp-33625	114	43	of	of	ADP
bjp-33625	114	44	drug	drug	NOUN
bjp-33625	114	45	likeness	likeness	NOUN
bjp-33625	114	46	rules	rule	NOUN
bjp-33625	114	47	discussed	discuss	VERB
bjp-33625	114	48	above	above	ADV
bjp-33625	114	49	.	.	PUNCT
bjp-33625	115	1	it	it	PRON
bjp-33625	115	2	was	be	AUX
bjp-33625	115	3	interesting	interesting	ADJ
bjp-33625	115	4	to	to	PART
bjp-33625	115	5	note	note	VERB
bjp-33625	115	6	that	that	SCONJ
bjp-33625	115	7	the	the	DET
bjp-33625	115	8	results	result	NOUN
bjp-33625	115	9	from	from	ADP
bjp-33625	115	10	the	the	DET
bjp-33625	115	11	swiss	swiss	ADJ
bjp-33625	115	12	adme	adme	NOUN
bjp-33625	115	13	predictor	predictor	NOUN
bjp-33625	115	14	values	value	NOUN
bjp-33625	115	15	of	of	ADP
bjp-33625	115	16	log	log	NOUN
bjp-33625	115	17	p	p	NOUN
bjp-33625	115	18	,	,	PUNCT
bjp-33625	115	19	molar	molar	ADJ
bjp-33625	115	20	refractivity	refractivity	NOUN
bjp-33625	115	21	,	,	PUNCT
bjp-33625	115	22	and	and	CCONJ
bjp-33625	115	23	the	the	DET
bjp-33625	115	24	total	total	ADJ
bjp-33625	115	25	polar	polar	ADJ
bjp-33625	115	26	surface	surface	NOUN
bjp-33625	115	27	area	area	NOUN
bjp-33625	115	28	in	in	ADP
bjp-33625	115	29	these	these	DET
bjp-33625	115	30	molecules	molecule	NOUN
bjp-33625	115	31	were	be	AUX
bjp-33625	115	32	in	in	ADP
bjp-33625	115	33	excellent	excellent	ADJ
bjp-33625	115	34	agreement	agreement	NOUN
bjp-33625	115	35	with	with	ADP
bjp-33625	115	36	the	the	DET
bjp-33625	115	37	most	most	ADV
bjp-33625	115	38	important	important	ADJ
bjp-33625	115	39	rules	rule	NOUN
bjp-33625	115	40	of	of	ADP
bjp-33625	115	41	drug	drug	NOUN
bjp-33625	115	42	likeness	likeness	NOUN
bjp-33625	115	43	.	.	PUNCT
bjp-33625	116	1	eg	eg	NOUN
bjp-33625	116	2	.	.	PUNCT
bjp-33625	117	1	lipinski	lipinski	PROPN
bjp-33625	117	2	,	,	PUNCT
bjp-33625	117	3	ghose	ghose	PROPN
bjp-33625	117	4	,	,	PUNCT
bjp-33625	117	5	veber	veber	PROPN
bjp-33625	117	6	,	,	PUNCT
bjp-33625	117	7	egan	egan	PROPN
bjp-33625	117	8	.	.	PUNCT
bjp-33625	118	1	though	though	SCONJ
bjp-33625	118	2	these	these	DET
bjp-33625	118	3	compounds	compound	NOUN
bjp-33625	118	4	were	be	AUX
bjp-33625	118	5	exhibiting	exhibit	VERB
bjp-33625	118	6	good	good	ADJ
bjp-33625	118	7	hydrophiliclipophilic	hydrophiliclipophilic	ADJ
bjp-33625	118	8	balance	balance	NOUN
bjp-33625	118	9	and	and	CCONJ
bjp-33625	118	10	same	same	ADJ
bjp-33625	118	11	predicted	predict	VERB
bjp-33625	118	12	bioavailability	bioavailability	NOUN
bjp-33625	118	13	,	,	PUNCT
bjp-33625	118	14	the	the	DET
bjp-33625	118	15	hydroxy	hydroxy	PROPN
bjp-33625	118	16	derivative	derivative	NOUN
bjp-33625	118	17	with	with	ADP
bjp-33625	118	18	high	high	ADJ
bjp-33625	118	19	lipophilicity	lipophilicity	NOUN
bjp-33625	118	20	was	be	AUX
bjp-33625	118	21	expecting	expect	VERB
bjp-33625	118	22	to	to	PART
bjp-33625	118	23	show	show	VERB
bjp-33625	118	24	decent	decent	ADJ
bjp-33625	118	25	gi	gi	NOUN
bjp-33625	118	26	absorption	absorption	NOUN
bjp-33625	118	27	.	.	PUNCT
bjp-33625	119	1	this	this	DET
bjp-33625	119	2	hydroxy	hydroxy	PROPN
bjp-33625	119	3	derivative	derivative	NOUN
bjp-33625	119	4	with	with	ADP
bjp-33625	119	5	a	a	DET
bjp-33625	119	6	higher	high	ADJ
bjp-33625	119	7	value	value	NOUN
bjp-33625	119	8	of	of	ADP
bjp-33625	119	9	probability	probability	NOUN
bjp-33625	119	10	of	of	ADP
bjp-33625	119	11	antimalarial	antimalarial	ADJ
bjp-33625	119	12	activity	activity	NOUN
bjp-33625	119	13	and	and	CCONJ
bjp-33625	119	14	non	non	ADJ
bjp-33625	119	15	-	-	ADJ
bjp-33625	119	16	carcinogenic	carcinogenic	ADJ
bjp-33625	119	17	and	and	CCONJ
bjp-33625	119	18	mutagenic	mutagenic	ADJ
bjp-33625	119	19	properties	property	NOUN
bjp-33625	119	20	were	be	AUX
bjp-33625	119	21	predicted	predict	VERB
bjp-33625	119	22	as	as	ADP
bjp-33625	119	23	the	the	DET
bjp-33625	119	24	lead	lead	NOUN
bjp-33625	119	25	in	in	ADP
bjp-33625	119	26	the	the	DET
bjp-33625	119	27	study	study	NOUN
bjp-33625	119	28	.	.	PUNCT
bjp-33625	120	1	the	the	DET
bjp-33625	120	2	results	result	NOUN
bjp-33625	120	3	obtained	obtain	VERB
bjp-33625	120	4	from	from	ADP
bjp-33625	120	5	the	the	DET
bjp-33625	120	6	swiss	swiss	ADJ
bjp-33625	120	7	adme	adme	NOUN
bjp-33625	120	8	search	search	NOUN
bjp-33625	120	9	engine	engine	NOUN
bjp-33625	120	10	are	be	AUX
bjp-33625	120	11	listed	list	VERB
bjp-33625	120	12	in	in	ADP
bjp-33625	120	13	table	table	NOUN
bjp-33625	120	14	i.	i.	NOUN
bjp-33625	120	15	the	the	DET
bjp-33625	120	16	pass	pass	NOUN
bjp-33625	120	17	activity	activity	NOUN
bjp-33625	120	18	prediction	prediction	NOUN
bjp-33625	120	19	for	for	ADP
bjp-33625	120	20	pyrazoline	pyrazoline	NOUN
bjp-33625	120	21	compounds	compound	NOUN
bjp-33625	120	22	given	give	VERB
bjp-33625	120	23	a	a	DET
bjp-33625	120	24	higher	high	ADJ
bjp-33625	120	25	value	value	NOUN
bjp-33625	120	26	of	of	ADP
bjp-33625	120	27	probability	probability	NOUN
bjp-33625	120	28	for	for	ADP
bjp-33625	120	29	antiprotozoal	antiprotozoal	ADJ
bjp-33625	120	30	action	action	NOUN
bjp-33625	120	31	(	(	PUNCT
bjp-33625	120	32	figure	figure	NOUN
bjp-33625	120	33	2	2	NUM
bjp-33625	120	34	)	)	PUNCT
bjp-33625	120	35	.	.	PUNCT
bjp-33625	121	1	the	the	DET
bjp-33625	121	2	results	result	NOUN
bjp-33625	121	3	obtained	obtain	VERB
bjp-33625	121	4	from	from	ADP
bjp-33625	121	5	activity	activity	NOUN
bjp-33625	121	6	prediction	prediction	NOUN
bjp-33625	121	7	are	be	AUX
bjp-33625	121	8	given	give	VERB
bjp-33625	121	9	in	in	ADP
bjp-33625	121	10	table	table	NOUN
bjp-33625	121	11	i.	i.	NOUN
bjp-33625	121	12	docking	dock	VERB
bjp-33625	121	13	the	the	DET
bjp-33625	121	14	extent	extent	NOUN
bjp-33625	121	15	of	of	ADP
bjp-33625	121	16	inhibition	inhibition	NOUN
bjp-33625	121	17	of	of	ADP
bjp-33625	121	18	all	all	DET
bjp-33625	121	19	the	the	DET
bjp-33625	121	20	synthesized	synthesize	VERB
bjp-33625	121	21	ligands	ligand	NOUN
bjp-33625	121	22	was	be	AUX
bjp-33625	121	23	compared	compare	VERB
bjp-33625	121	24	with	with	ADP
bjp-33625	121	25	inhibition	inhibition	NOUN
bjp-33625	121	26	produced	produce	VERB
bjp-33625	121	27	by	by	ADP
bjp-33625	121	28	standard	standard	ADJ
bjp-33625	121	29	drug	drug	NOUN
bjp-33625	121	30	chloroquine	chloroquine	NOUN
bjp-33625	121	31	.	.	PUNCT
bjp-33625	122	1	efforts	effort	NOUN
bjp-33625	122	2	were	be	AUX
bjp-33625	122	3	made	make	VERB
bjp-33625	122	4	to	to	PART
bjp-33625	122	5	study	study	VERB
bjp-33625	122	6	and	and	CCONJ
bjp-33625	122	7	compare	compare	VERB
bjp-33625	122	8	the	the	DET
bjp-33625	122	9	amino	amino	NOUN
bjp-33625	122	10	acid	acid	NOUN
bjp-33625	122	11	residues	residue	NOUN
bjp-33625	122	12	involved	involve	VERB
bjp-33625	122	13	in	in	ADP
bjp-33625	122	14	enzyme	enzyme	NOUN
bjp-33625	122	15	inhibition	inhibition	NOUN
bjp-33625	122	16	.	.	PUNCT
bjp-33625	123	1	the	the	DET
bjp-33625	123	2	results	result	NOUN
bjp-33625	123	3	obtained	obtain	VERB
bjp-33625	123	4	were	be	AUX
bjp-33625	123	5	given	give	VERB
bjp-33625	123	6	in	in	ADP
bjp-33625	123	7	table	table	NOUN
bjp-33625	123	8	ii	ii	PROPN
bjp-33625	123	9	.	.	PUNCT
bjp-33625	124	1	n	n	CCONJ
bjp-33625	124	2	n	n	ADP
bjp-33625	124	3	h	h	NOUN
bjp-33625	125	1	n	n	CCONJ
bjp-33625	125	2	no2n	no2n	PROPN
bjp-33625	125	3	ch3	ch3	PROPN
bjp-33625	125	4	ch2conhnh2	ch2conhnh2	NOUN
bjp-33625	125	5	n	n	CCONJ
bjp-33625	125	6	n	n	PROPN
bjp-33625	125	7	h	h	NOUN
bjp-33625	125	8	n	n	CCONJ
bjp-33625	125	9	n	n	NOUN
bjp-33625	125	10	r	r	NOUN
bjp-33625	125	11	c	c	NOUN
bjp-33625	125	12	o	o	NOUN
bjp-33625	125	13	h2c	h2c	PROPN
bjp-33625	125	14	n	n	CCONJ
bjp-33625	125	15	n	n	PRON
bjp-33625	125	16	no2	no2	NOUN
bjp-33625	125	17	h3c	h3c	VERB
bjp-33625	125	18	benzimidazole	benzimidazole	ADJ
bjp-33625	125	19	chalcone	chalcone	NOUN
bjp-33625	125	20	imidazole	imidazole	NOUN
bjp-33625	125	21	hydrazide	hydrazide	ADV
bjp-33625	126	1	o	o	NOUN
bjp-33625	126	2	r	r	NOUN
bjp-33625	126	3	+	+	NUM
bjp-33625	126	4	scheme	scheme	NOUN
bjp-33625	126	5	3	3	NUM
bjp-33625	126	6	:	:	PUNCT
bjp-33625	126	7	synthesis	synthesis	NOUN
bjp-33625	126	8	of	of	ADP
bjp-33625	126	9	1-[3-(1h	1-[3-(1h	PROPN
bjp-33625	126	10	-	-	PUNCT
bjp-33625	126	11	benzoimidazol-2	benzoimidazol-2	NUM
bjp-33625	126	12	-	-	PUNCT
bjp-33625	126	13	yl)-4	yl)-4	VERB
bjp-33625	126	14	,	,	PUNCT
bjp-33625	126	15	5	5	NUM
bjp-33625	126	16	-	-	PUNCT
bjp-33625	126	17	dihydro	dihydro	NOUN
bjp-33625	126	18	-	-	PUNCT
bjp-33625	126	19	pyrazol-1	pyrazol-1	NUM
bjp-33625	126	20	-	-	PUNCT
bjp-33625	126	21	yl]-2-(2	yl]-2-(2	NOUN
bjp-33625	126	22	-	-	PUNCT
bjp-33625	126	23	methyl-5	methyl-5	NOUN
bjp-33625	126	24	-	-	PUNCT
bjp-33625	126	25	nitro	nitro	NOUN
bjp-33625	126	26	-	-	PUNCT
bjp-33625	126	27	imidazol-1	imidazol-1	NUM
bjp-33625	126	28	-	-	PUNCT
bjp-33625	126	29	yl)-ethanone	yl)-ethanone	NOUN
bjp-33625	126	30	26	26	NUM
bjp-33625	126	31	bangladesh	bangladesh	PROPN
bjp-33625	126	32	j	j	PROPN
bjp-33625	126	33	pharmacol	pharmacol	PROPN
bjp-33625	126	34	2018	2018	NUM
bjp-33625	126	35	;	;	PUNCT
bjp-33625	126	36	13	13	NUM
bjp-33625	126	37	:	:	SYM
bjp-33625	126	38	23	23	NUM
bjp-33625	126	39	-	-	SYM
bjp-33625	126	40	29	29	NUM
bjp-33625	126	41	the	the	DET
bjp-33625	126	42	four	four	NUM
bjp-33625	126	43	successful	successful	ADJ
bjp-33625	126	44	synthetic	synthetic	ADJ
bjp-33625	126	45	derivatives	derivative	NOUN
bjp-33625	126	46	screened	screen	VERB
bjp-33625	126	47	for	for	ADP
bjp-33625	126	48	in	in	ADP
bjp-33625	126	49	silico	silico	NOUN
bjp-33625	126	50	adme	adme	NOUN
bjp-33625	126	51	and	and	CCONJ
bjp-33625	126	52	toxicity	toxicity	NOUN
bjp-33625	126	53	studies	study	NOUN
bjp-33625	126	54	when	when	SCONJ
bjp-33625	126	55	subjected	subject	VERB
bjp-33625	126	56	to	to	ADP
bjp-33625	126	57	docking	dock	VERB
bjp-33625	126	58	studies	study	NOUN
bjp-33625	126	59	the	the	DET
bjp-33625	126	60	most	most	ADV
bjp-33625	126	61	affluent	affluent	ADJ
bjp-33625	126	62	outcome	outcome	NOUN
bjp-33625	126	63	was	be	AUX
bjp-33625	126	64	again	again	ADV
bjp-33625	126	65	found	find	VERB
bjp-33625	126	66	to	to	PART
bjp-33625	126	67	match	match	VERB
bjp-33625	126	68	with	with	ADP
bjp-33625	126	69	the	the	DET
bjp-33625	126	70	results	result	NOUN
bjp-33625	126	71	obtained	obtain	VERB
bjp-33625	126	72	from	from	ADP
bjp-33625	126	73	adme	adme	NOUN
bjp-33625	126	74	analysis	analysis	NOUN
bjp-33625	126	75	.	.	PUNCT
bjp-33625	127	1	the	the	DET
bjp-33625	127	2	compound	compound	NOUN
bjp-33625	127	3	code-3	code-3	PRON
bjp-33625	127	4	exhibits	exhibit	VERB
bjp-33625	127	5	highest	high	ADJ
bjp-33625	127	6	–	–	PUNCT
bjp-33625	127	7	cdocker	cdocker	NOUN
bjp-33625	127	8	energy	energy	NOUN
bjp-33625	127	9	and	and	CCONJ
bjp-33625	127	10	–	–	PUNCT
bjp-33625	127	11	cdocker	cdocker	NOUN
bjp-33625	127	12	interaction	interaction	NOUN
bjp-33625	127	13	values	value	NOUN
bjp-33625	127	14	comparable	comparable	ADJ
bjp-33625	127	15	with	with	ADP
bjp-33625	127	16	standard	standard	ADJ
bjp-33625	127	17	drug	drug	NOUN
bjp-33625	127	18	chloroquine	chloroquine	NOUN
bjp-33625	127	19	.	.	PUNCT
bjp-33625	128	1	unlike	unlike	ADP
bjp-33625	128	2	all	all	DET
bjp-33625	128	3	other	other	ADJ
bjp-33625	128	4	ligands	ligand	NOUN
bjp-33625	128	5	,	,	PUNCT
bjp-33625	128	6	the	the	DET
bjp-33625	128	7	hydroxy	hydroxy	PROPN
bjp-33625	128	8	terminal	terminal	PROPN
bjp-33625	128	9	substitution	substitution	NOUN
bjp-33625	128	10	exhibited	exhibit	VERB
bjp-33625	128	11	a	a	DET
bjp-33625	128	12	high	high	ADJ
bjp-33625	128	13	number	number	NOUN
bjp-33625	128	14	of	of	ADP
bjp-33625	128	15	stronger	strong	ADJ
bjp-33625	128	16	electrostatic	electrostatic	ADJ
bjp-33625	128	17	interactions	interaction	NOUN
bjp-33625	128	18	.	.	PUNCT
bjp-33625	129	1	the	the	DET
bjp-33625	129	2	three	three	NUM
bjp-33625	129	3	hydrogen	hydrogen	NOUN
bjp-33625	129	4	bond	bond	NOUN
bjp-33625	129	5	interactions	interaction	NOUN
bjp-33625	129	6	associated	associate	VERB
bjp-33625	129	7	with	with	ADP
bjp-33625	129	8	pi	pi	NOUN
bjp-33625	129	9	bond	bond	NOUN
bjp-33625	129	10	between	between	ADP
bjp-33625	129	11	benzimidazole	benzimidazole	PROPN
bjp-33625	129	12	ring	ring	NOUN
bjp-33625	129	13	and	and	CCONJ
bjp-33625	129	14	amino	amino	NOUN
bjp-33625	129	15	acid	acid	NOUN
bjp-33625	129	16	residue	residue	NOUN
bjp-33625	129	17	in	in	ADP
bjp-33625	129	18	chain	chain	NOUN
bjp-33625	129	19	a	a	PRON
bjp-33625	129	20	of	of	ADP
bjp-33625	129	21	dihydrofolate	dihydrofolate	NOUN
bjp-33625	129	22	seems	seem	VERB
bjp-33625	129	23	to	to	PART
bjp-33625	129	24	be	be	AUX
bjp-33625	129	25	the	the	DET
bjp-33625	129	26	reason	reason	NOUN
bjp-33625	129	27	for	for	ADP
bjp-33625	129	28	the	the	DET
bjp-33625	129	29	significance	significance	NOUN
bjp-33625	129	30	of	of	ADP
bjp-33625	129	31	compound-3	compound-3	NOUN
bjp-33625	129	32	.	.	PUNCT
bjp-33625	130	1	the	the	DET
bjp-33625	130	2	compound	compound	NOUN
bjp-33625	130	3	code-3	code-3	NUM
bjp-33625	130	4	is	be	AUX
bjp-33625	130	5	in	in	ADP
bjp-33625	130	6	good	good	ADJ
bjp-33625	130	7	correlation	correlation	NOUN
bjp-33625	130	8	with	with	ADP
bjp-33625	130	9	standard	standard	ADJ
bjp-33625	130	10	drug	drug	NOUN
bjp-33625	130	11	chloroquine	chloroquine	NOUN
bjp-33625	130	12	in	in	ADP
bjp-33625	130	13	binding	bind	VERB
bjp-33625	130	14	energy	energy	NOUN
bjp-33625	130	15	and	and	CCONJ
bjp-33625	130	16	number	number	NOUN
bjp-33625	130	17	of	of	ADP
bjp-33625	130	18	hydrogen	hydrogen	NOUN
bjp-33625	130	19	bond	bond	NOUN
bjp-33625	130	20	interaction	interaction	NOUN
bjp-33625	130	21	at	at	ADP
bjp-33625	130	22	the	the	DET
bjp-33625	130	23	drug	drug	NOUN
bjp-33625	130	24	receptor	receptor	NOUN
bjp-33625	130	25	.	.	PUNCT
bjp-33625	131	1	the	the	DET
bjp-33625	131	2	types	type	NOUN
bjp-33625	131	3	and	and	CCONJ
bjp-33625	131	4	number	number	NOUN
bjp-33625	131	5	of	of	ADP
bjp-33625	131	6	interactions	interaction	NOUN
bjp-33625	131	7	between	between	ADP
bjp-33625	131	8	the	the	DET
bjp-33625	131	9	synthesized	synthesize	VERB
bjp-33625	131	10	ligands	ligand	NOUN
bjp-33625	131	11	and	and	CCONJ
bjp-33625	131	12	enzyme	enzyme	NOUN
bjp-33625	131	13	are	be	AUX
bjp-33625	131	14	shown	show	VERB
bjp-33625	131	15	in	in	ADP
bjp-33625	131	16	figure	figure	NOUN
bjp-33625	131	17	2	2	NUM
bjp-33625	131	18	,	,	PUNCT
bjp-33625	131	19	and	and	CCONJ
bjp-33625	131	20	the	the	DET
bjp-33625	131	21	data	datum	NOUN
bjp-33625	131	22	are	be	AUX
bjp-33625	131	23	tabulated	tabulate	VERB
bjp-33625	131	24	in	in	ADP
bjp-33625	131	25	table	table	NOUN
bjp-33625	131	26	ii	ii	PROPN
bjp-33625	131	27	.	.	PUNCT
bjp-33625	131	28	figure	figure	NOUN
bjp-33625	131	29	2	2	NUM
bjp-33625	131	30	exhibits	exhibit	VERB
bjp-33625	131	31	the	the	DET
bjp-33625	131	32	prominent	prominent	ADJ
bjp-33625	131	33	lipophilicity	lipophilicity	NOUN
bjp-33625	131	34	of	of	ADP
bjp-33625	131	35	compound	compound	NOUN
bjp-33625	131	36	3	3	NUM
bjp-33625	131	37	by	by	ADP
bjp-33625	131	38	the	the	DET
bjp-33625	131	39	way	way	NOUN
bjp-33625	131	40	it	it	PRON
bjp-33625	131	41	fit	fit	VERB
bjp-33625	131	42	into	into	ADP
bjp-33625	131	43	the	the	DET
bjp-33625	131	44	hydrophobic	hydrophobic	NOUN
bjp-33625	131	45	pocket	pocket	NOUN
bjp-33625	131	46	of	of	ADP
bjp-33625	131	47	the	the	DET
bjp-33625	131	48	receptor	receptor	NOUN
bjp-33625	131	49	.	.	PUNCT
bjp-33625	132	1	this	this	PRON
bjp-33625	132	2	clearly	clearly	ADV
bjp-33625	132	3	represents	represent	VERB
bjp-33625	132	4	hydrophobic	hydrophobic	NOUN
bjp-33625	132	5	amino	amino	NOUN
bjp-33625	132	6	acid	acid	NOUN
bjp-33625	132	7	terminals	terminal	NOUN
bjp-33625	132	8	is	be	AUX
bjp-33625	132	9	located	locate	VERB
bjp-33625	132	10	within	within	ADP
bjp-33625	132	11	that	that	DET
bjp-33625	132	12	region	region	NOUN
bjp-33625	132	13	of	of	ADP
bjp-33625	132	14	receptor	receptor	NOUN
bjp-33625	132	15	and	and	CCONJ
bjp-33625	132	16	facilitates	facilitate	VERB
bjp-33625	132	17	stronger	strong	ADJ
bjp-33625	132	18	binding	bind	VERB
bjp-33625	132	19	with	with	ADP
bjp-33625	132	20	a	a	DET
bjp-33625	132	21	lipophilic	lipophilic	ADJ
bjp-33625	132	22	ligand	ligand	NOUN
bjp-33625	132	23	.	.	PUNCT
bjp-33625	133	1	antimalarial	antimalarial	ADJ
bjp-33625	133	2	activity	activity	NOUN
bjp-33625	133	3	the	the	PRON
bjp-33625	133	4	in	in	X
bjp-33625	133	5	vitro	vitro	X
bjp-33625	133	6	antimalarial	antimalarial	ADJ
bjp-33625	133	7	assay	assay	NOUN
bjp-33625	133	8	results	result	NOUN
bjp-33625	133	9	showed	show	VERB
bjp-33625	133	10	that	that	SCONJ
bjp-33625	133	11	the	the	DET
bjp-33625	133	12	representative	representative	ADJ
bjp-33625	133	13	compounds	compound	NOUN
bjp-33625	133	14	exhibited	exhibit	VERB
bjp-33625	133	15	antimalarial	antimalarial	ADJ
bjp-33625	133	16	figure	figure	NOUN
bjp-33625	133	17	2	2	NUM
bjp-33625	133	18	:	:	PUNCT
bjp-33625	133	19	binding	bind	VERB
bjp-33625	133	20	configuration	configuration	NOUN
bjp-33625	133	21	of	of	ADP
bjp-33625	133	22	synthesized	synthesize	VERB
bjp-33625	133	23	derivatives	derivative	NOUN
bjp-33625	133	24	(	(	PUNCT
bjp-33625	133	25	discovery	discovery	NOUN
bjp-33625	133	26	studio	studio	NOUN
bjp-33625	133	27	3.5	3.5	NUM
bjp-33625	133	28	software	software	NOUN
bjp-33625	133	29	)	)	PUNCT
bjp-33625	133	30	compound	compound	NOUN
bjp-33625	133	31	1	1	NUM
bjp-33625	133	32	compound	compound	NOUN
bjp-33625	133	33	2	2	NUM
bjp-33625	133	34	compound	compound	NOUN
bjp-33625	133	35	3	3	NUM
bjp-33625	133	36	compound	compound	NOUN
bjp-33625	133	37	4	4	NUM
bjp-33625	133	38	electrostatic	electrostatic	ADJ
bjp-33625	133	39	van	van	PROPN
bjp-33625	133	40	der	der	NOUN
bjp-33625	133	41	waals	waal	NOUN
bjp-33625	133	42	table	table	VERB
bjp-33625	133	43	i	i	PRON
bjp-33625	133	44	physiochemical	physiochemical	ADJ
bjp-33625	133	45	properties	property	NOUN
bjp-33625	133	46	of	of	ADP
bjp-33625	133	47	synthesized	synthesize	VERB
bjp-33625	133	48	ligands	ligand	NOUN
bjp-33625	133	49	physiochemical	physiochemical	ADJ
bjp-33625	133	50	properties	property	NOUN
bjp-33625	133	51	,	,	PUNCT
bjp-33625	133	52	lipophilicity	lipophilicity	NOUN
bjp-33625	133	53	and	and	CCONJ
bjp-33625	133	54	water	water	NOUN
bjp-33625	133	55	solubility	solubility	NOUN
bjp-33625	133	56	antiprotozoal	antiprotozoal	ADJ
bjp-33625	133	57	activity	activity	NOUN
bjp-33625	133	58	prediction	prediction	NOUN
bjp-33625	133	59	compound	compound	NOUN
bjp-33625	133	60	code	code	NOUN
bjp-33625	133	61	molecular	molecular	ADJ
bjp-33625	133	62	weight	weight	NOUN
bjp-33625	133	63	(	(	PUNCT
bjp-33625	133	64	g	g	NOUN
bjp-33625	133	65	/	/	SYM
bjp-33625	133	66	mol	mol	NOUN
bjp-33625	133	67	)	)	PUNCT
bjp-33625	133	68	no	no	NOUN
bjp-33625	133	69	.	.	NOUN
bjp-33625	133	70	of	of	ADP
bjp-33625	133	71	hydrogen	hydrogen	NOUN
bjp-33625	133	72	bond	bond	NOUN
bjp-33625	133	73	donors	donor	NOUN
bjp-33625	133	74	no	no	INTJ
bjp-33625	133	75	.	.	PUNCT
bjp-33625	133	76	of	of	ADP
bjp-33625	133	77	hydrogen	hydrogen	NOUN
bjp-33625	133	78	bond	bond	NOUN
bjp-33625	133	79	acceptors	acceptor	NOUN
bjp-33625	133	80	no	no	ADV
bjp-33625	133	81	.	.	PUNCT
bjp-33625	134	1	of	of	ADP
bjp-33625	134	2	rotatable	rotatable	ADJ
bjp-33625	134	3	bonds	bond	NOUN
bjp-33625	134	4	total	total	VERB
bjp-33625	134	5	polar	polar	ADJ
bjp-33625	134	6	surface	surface	NOUN
bjp-33625	134	7	area	area	NOUN
bjp-33625	134	8	(	(	PUNCT
bjp-33625	134	9	a	a	DET
bjp-33625	134	10	°	°	PROPN
bjp-33625	134	11	)	)	PUNCT
bjp-33625	135	1	log	log	NOUN
bjp-33625	135	2	p	p	NOUN
bjp-33625	135	3	(	(	PUNCT
bjp-33625	135	4	ilogp	ilogp	NOUN
bjp-33625	135	5	)	)	PUNCT
bjp-33625	135	6	log	log	NOUN
bjp-33625	135	7	s	s	PART
bjp-33625	135	8	(	(	PUNCT
bjp-33625	135	9	esol	esol	PROPN
bjp-33625	135	10	)	)	PUNCT
bjp-33625	136	1	pa	pa	PROPN
bjp-33625	136	2	pi	pi	NOUN
bjp-33625	136	3	1	1	NUM
bjp-33625	136	4	463.8	463.8	NUM
bjp-33625	136	5	1	1	NUM
bjp-33625	136	6	6	6	NUM
bjp-33625	136	7	6	6	NUM
bjp-33625	136	8	124.9	124.9	NUM
bjp-33625	136	9	2.6	2.6	NUM
bjp-33625	136	10	-5.1	-5.1	X
bjp-33625	136	11	0.6	0.6	NUM
bjp-33625	136	12	0.0	0.0	NUM
bjp-33625	136	13	2	2	NUM
bjp-33625	136	14	447.4	447.4	NUM
bjp-33625	136	15	1	1	NUM
bjp-33625	136	16	7	7	NUM
bjp-33625	136	17	6	6	NUM
bjp-33625	136	18	124.9	124.9	NUM
bjp-33625	136	19	2.3	2.3	NUM
bjp-33625	136	20	-4.6	-4.6	NOUN
bjp-33625	136	21	0.6	0.6	NUM
bjp-33625	136	22	0.0	0.0	NUM
bjp-33625	136	23	3	3	NUM
bjp-33625	136	24	445.4	445.4	NUM
bjp-33625	136	25	2	2	NUM
bjp-33625	136	26	7	7	NUM
bjp-33625	136	27	6	6	NUM
bjp-33625	136	28	145.2	145.2	NUM
bjp-33625	136	29	2.2	2.2	NUM
bjp-33625	136	30	-4.3	-4.3	NOUN
bjp-33625	136	31	0.6	0.6	NUM
bjp-33625	136	32	0.0	0.0	NUM
bjp-33625	136	33	4	4	NUM
bjp-33625	136	34	455.4	455.4	NUM
bjp-33625	136	35	1	1	NUM
bjp-33625	136	36	6	6	NUM
bjp-33625	136	37	7	7	NUM
bjp-33625	136	38	124.9	124.9	NUM
bjp-33625	136	39	3.4	3.4	NUM
bjp-33625	136	40	-4.9	-4.9	NOUN
bjp-33625	136	41	0.6	0.6	NUM
bjp-33625	136	42	0.0	0.0	NUM
bjp-33625	136	43	pa	pa	NOUN
bjp-33625	136	44	=	=	NOUN
bjp-33625	136	45	probability	probability	NOUN
bjp-33625	136	46	to	to	AUX
bjp-33625	136	47	active	active	ADJ
bjp-33625	136	48	;	;	PUNCT
bjp-33625	136	49	pi	pi	NOUN
bjp-33625	136	50	=	=	SYM
bjp-33625	136	51	probability	probability	NOUN
bjp-33625	136	52	to	to	PART
bjp-33625	136	53	inactive	inactive	ADJ
bjp-33625	136	54	bangladesh	bangladesh	PROPN
bjp-33625	136	55	j	j	PROPN
bjp-33625	136	56	pharmacol	pharmacol	PROPN
bjp-33625	136	57	2018	2018	NUM
bjp-33625	136	58	;	;	PUNCT
bjp-33625	136	59	13	13	NUM
bjp-33625	136	60	:	:	SYM
bjp-33625	136	61	23	23	NUM
bjp-33625	136	62	-	-	SYM
bjp-33625	136	63	29	29	NUM
bjp-33625	136	64	27	27	NUM
bjp-33625	136	65	activity	activity	NOUN
bjp-33625	136	66	at	at	ADP
bjp-33625	136	67	50	50	NUM
bjp-33625	136	68	mg	mg	NUM
bjp-33625	136	69	/	/	SYM
bjp-33625	136	70	ml	ml	PROPN
bjp-33625	136	71	(	(	PUNCT
bjp-33625	136	72	table	table	NOUN
bjp-33625	136	73	iii	iii	NOUN
bjp-33625	136	74	)	)	PUNCT
bjp-33625	136	75	.	.	PUNCT
bjp-33625	137	1	the	the	DET
bjp-33625	137	2	smears	smear	NOUN
bjp-33625	137	3	when	when	SCONJ
bjp-33625	137	4	accessed	access	VERB
bjp-33625	137	5	for	for	ADP
bjp-33625	137	6	a	a	DET
bjp-33625	137	7	number	number	NOUN
bjp-33625	137	8	of	of	ADP
bjp-33625	137	9	dead	dead	ADJ
bjp-33625	137	10	cells	cell	NOUN
bjp-33625	137	11	,	,	PUNCT
bjp-33625	137	12	as	as	SCONJ
bjp-33625	137	13	expected	expect	VERB
bjp-33625	137	14	the	the	DET
bjp-33625	137	15	compounds	compound	NOUN
bjp-33625	137	16	showed	show	VERB
bjp-33625	137	17	good	good	ADJ
bjp-33625	137	18	correlation	correlation	NOUN
bjp-33625	137	19	with	with	ADP
bjp-33625	137	20	docking	docking	NOUN
bjp-33625	137	21	results	result	NOUN
bjp-33625	137	22	.	.	PUNCT
bjp-33625	138	1	the	the	DET
bjp-33625	138	2	smears	smear	NOUN
bjp-33625	138	3	were	be	AUX
bjp-33625	138	4	assessed	assess	VERB
bjp-33625	138	5	for	for	ADP
bjp-33625	138	6	live	live	ADJ
bjp-33625	138	7	and	and	CCONJ
bjp-33625	138	8	dead	dead	ADJ
bjp-33625	138	9	parasites	parasite	NOUN
bjp-33625	138	10	.	.	PUNCT
bjp-33625	139	1	the	the	DET
bjp-33625	139	2	significance	significance	NOUN
bjp-33625	139	3	of	of	ADP
bjp-33625	139	4	computer	computer	NOUN
bjp-33625	139	5	in	in	ADP
bjp-33625	139	6	the	the	DET
bjp-33625	139	7	prediction	prediction	NOUN
bjp-33625	139	8	of	of	ADP
bjp-33625	139	9	activity	activity	NOUN
bjp-33625	139	10	can	can	AUX
bjp-33625	139	11	be	be	AUX
bjp-33625	139	12	substantiated	substantiate	VERB
bjp-33625	139	13	by	by	ADP
bjp-33625	139	14	correlating	correlate	VERB
bjp-33625	139	15	the	the	DET
bjp-33625	139	16	activity	activity	NOUN
bjp-33625	139	17	profile	profile	NOUN
bjp-33625	139	18	with	with	ADP
bjp-33625	139	19	the	the	PRON
bjp-33625	139	20	in	in	ADP
bjp-33625	139	21	silico	silico	NOUN
bjp-33625	139	22	data	datum	NOUN
bjp-33625	139	23	(	(	PUNCT
bjp-33625	139	24	table	table	NOUN
bjp-33625	139	25	ii	ii	PROPN
bjp-33625	139	26	)	)	PUNCT
bjp-33625	139	27	.	.	PUNCT
bjp-33625	140	1	the	the	DET
bjp-33625	140	2	antimalarial	antimalarial	ADJ
bjp-33625	140	3	activity	activity	NOUN
bjp-33625	140	4	is	be	AUX
bjp-33625	140	5	compared	compare	VERB
bjp-33625	140	6	with	with	ADP
bjp-33625	140	7	the	the	DET
bjp-33625	140	8	dock	dock	NOUN
bjp-33625	140	9	scores	score	NOUN
bjp-33625	140	10	(	(	PUNCT
bjp-33625	140	11	binding	bind	VERB
bjp-33625	140	12	energy	energy	NOUN
bjp-33625	140	13	)	)	PUNCT
bjp-33625	140	14	of	of	ADP
bjp-33625	140	15	the	the	DET
bjp-33625	140	16	synthesized	synthesize	VERB
bjp-33625	140	17	compounds	compound	NOUN
bjp-33625	140	18	using	use	VERB
bjp-33625	140	19	graphpad	graphpad	NOUN
bjp-33625	140	20	prism	prism	NOUN
bjp-33625	140	21	7	7	NUM
bjp-33625	140	22	.	.	PUNCT
bjp-33625	141	1	the	the	DET
bjp-33625	141	2	correlation	correlation	NOUN
bjp-33625	141	3	coefficient	coefficient	NOUN
bjp-33625	141	4	value	value	NOUN
bjp-33625	141	5	“	"	PUNCT
bjp-33625	141	6	r	r	NOUN
bjp-33625	141	7	”	"	PUNCT
bjp-33625	141	8	0.9929	0.9929	NUM
bjp-33625	141	9	found	find	VERB
bjp-33625	141	10	too	too	ADV
bjp-33625	141	11	significant	significant	ADJ
bjp-33625	141	12	for	for	ADP
bjp-33625	141	13	correlating	correlate	VERB
bjp-33625	141	14	antimalarial	antimalarial	ADJ
bjp-33625	141	15	activity	activity	NOUN
bjp-33625	141	16	and	and	CCONJ
bjp-33625	141	17	predicted	predict	VERB
bjp-33625	141	18	docking	docking	NOUN
bjp-33625	141	19	score	score	NOUN
bjp-33625	141	20	.	.	PUNCT
bjp-33625	142	1	discussion	discussion	NOUN
bjp-33625	142	2	the	the	DET
bjp-33625	142	3	web	web	NOUN
bjp-33625	142	4	-	-	PUNCT
bjp-33625	142	5	based	base	VERB
bjp-33625	142	6	adme	adme	NOUN
bjp-33625	142	7	studies	study	NOUN
bjp-33625	142	8	,	,	PUNCT
bjp-33625	142	9	bioactivity	bioactivity	NOUN
bjp-33625	142	10	prediction	prediction	NOUN
bjp-33625	142	11	,	,	PUNCT
bjp-33625	142	12	docking	docking	NOUN
bjp-33625	142	13	and	and	CCONJ
bjp-33625	142	14	in	in	ADP
bjp-33625	142	15	vitro	vitro	X
bjp-33625	142	16	studies	study	NOUN
bjp-33625	142	17	are	be	AUX
bjp-33625	142	18	carried	carry	VERB
bjp-33625	142	19	out	out	ADP
bjp-33625	142	20	for	for	ADP
bjp-33625	142	21	those	those	DET
bjp-33625	142	22	molecules	molecule	NOUN
bjp-33625	142	23	,	,	PUNCT
bjp-33625	142	24	which	which	PRON
bjp-33625	142	25	filtered	filter	VERB
bjp-33625	142	26	off	off	ADP
bjp-33625	142	27	from	from	ADP
bjp-33625	142	28	drug	drug	NOUN
bjp-33625	142	29	rules	rule	NOUN
bjp-33625	142	30	.	.	PUNCT
bjp-33625	143	1	the	the	DET
bjp-33625	143	2	authors	author	NOUN
bjp-33625	143	3	are	be	AUX
bjp-33625	143	4	successful	successful	ADJ
bjp-33625	143	5	in	in	ADP
bjp-33625	143	6	deriving	derive	VERB
bjp-33625	143	7	a	a	DET
bjp-33625	143	8	correlation	correlation	NOUN
bjp-33625	143	9	for	for	ADP
bjp-33625	143	10	synthesized	synthesize	VERB
bjp-33625	143	11	compounds	compound	NOUN
bjp-33625	143	12	among	among	ADP
bjp-33625	143	13	the	the	DET
bjp-33625	143	14	bioactive	bioactive	ADJ
bjp-33625	143	15	parameters	parameter	NOUN
bjp-33625	143	16	.	.	PUNCT
bjp-33625	144	1	the	the	DET
bjp-33625	144	2	correlation	correlation	NOUN
bjp-33625	144	3	coefficient	coefficient	NOUN
bjp-33625	144	4	value	value	NOUN
bjp-33625	144	5	obtained	obtain	VERB
bjp-33625	144	6	after	after	ADP
bjp-33625	144	7	comparing	compare	VERB
bjp-33625	144	8	the	the	DET
bjp-33625	144	9	docking	docking	NOUN
bjp-33625	144	10	score	score	NOUN
bjp-33625	144	11	and	and	CCONJ
bjp-33625	144	12	antimalarial	antimalarial	ADJ
bjp-33625	144	13	activity	activity	NOUN
bjp-33625	144	14	clearly	clearly	ADV
bjp-33625	144	15	reflect	reflect	VERB
bjp-33625	144	16	a	a	DET
bjp-33625	144	17	positive	positive	ADJ
bjp-33625	144	18	equation	equation	NOUN
bjp-33625	144	19	exist	exist	VERB
bjp-33625	144	20	between	between	ADP
bjp-33625	144	21	all	all	DET
bjp-33625	144	22	tested	test	VERB
bjp-33625	144	23	parameters	parameter	NOUN
bjp-33625	144	24	.	.	PUNCT
bjp-33625	145	1	it	it	PRON
bjp-33625	145	2	was	be	AUX
bjp-33625	145	3	interesting	interesting	ADJ
bjp-33625	145	4	to	to	PART
bjp-33625	145	5	note	note	VERB
bjp-33625	145	6	the	the	DET
bjp-33625	145	7	swiss	swiss	ADJ
bjp-33625	145	8	adme	adme	NOUN
bjp-33625	145	9	prediction	prediction	NOUN
bjp-33625	145	10	and	and	CCONJ
bjp-33625	145	11	pass	pass	VERB
bjp-33625	145	12	bioactivity	bioactivity	NOUN
bjp-33625	145	13	prediction	prediction	NOUN
bjp-33625	145	14	results	result	NOUN
bjp-33625	145	15	also	also	ADV
bjp-33625	145	16	in	in	ADP
bjp-33625	145	17	coherence	coherence	NOUN
bjp-33625	145	18	with	with	ADP
bjp-33625	145	19	final	final	ADJ
bjp-33625	145	20	results	result	NOUN
bjp-33625	145	21	.	.	PUNCT
bjp-33625	146	1	this	this	DET
bjp-33625	146	2	combination	combination	NOUN
bjp-33625	146	3	of	of	ADP
bjp-33625	146	4	pass	pass	NOUN
bjp-33625	146	5	-	-	PUNCT
bjp-33625	146	6	swiss	swiss	ADJ
bjp-33625	146	7	-	-	PUNCT
bjp-33625	146	8	docking	docking	NOUN
bjp-33625	146	9	in	in	ADP
bjp-33625	146	10	silico	silico	NOUN
bjp-33625	146	11	prediction	prediction	NOUN
bjp-33625	146	12	method	method	NOUN
bjp-33625	146	13	found	find	VERB
bjp-33625	146	14	to	to	ADP
bjp-33625	146	15	more	more	ADV
bjp-33625	146	16	sensitive	sensitive	ADJ
bjp-33625	146	17	and	and	CCONJ
bjp-33625	146	18	can	can	AUX
bjp-33625	146	19	work	work	VERB
bjp-33625	146	20	with	with	ADP
bjp-33625	146	21	other	other	ADJ
bjp-33625	146	22	molecules	molecule	NOUN
bjp-33625	146	23	too	too	ADV
bjp-33625	146	24	.	.	PUNCT
bjp-33625	147	1	when	when	SCONJ
bjp-33625	147	2	it	it	PRON
bjp-33625	147	3	comes	come	VERB
bjp-33625	147	4	to	to	ADP
bjp-33625	147	5	scaffold	scaffold	NOUN
bjp-33625	147	6	chemistry	chemistry	NOUN
bjp-33625	147	7	,	,	PUNCT
bjp-33625	147	8	the	the	DET
bjp-33625	147	9	docking	docking	NOUN
bjp-33625	147	10	results	result	NOUN
bjp-33625	147	11	are	be	AUX
bjp-33625	147	12	in	in	ADP
bjp-33625	147	13	agreement	agreement	NOUN
bjp-33625	147	14	with	with	ADP
bjp-33625	147	15	the	the	DET
bjp-33625	147	16	selection	selection	NOUN
bjp-33625	147	17	of	of	ADP
bjp-33625	147	18	pyrazoline	pyrazoline	NOUN
bjp-33625	147	19	part	part	NOUN
bjp-33625	147	20	as	as	ADP
bjp-33625	147	21	a	a	DET
bjp-33625	147	22	scaffold	scaffold	NOUN
bjp-33625	147	23	in	in	ADP
bjp-33625	147	24	the	the	DET
bjp-33625	147	25	entire	entire	ADJ
bjp-33625	147	26	molecule	molecule	NOUN
bjp-33625	147	27	.	.	PUNCT
bjp-33625	148	1	the	the	DET
bjp-33625	148	2	scaffold	scaffold	NOUN
bjp-33625	148	3	is	be	AUX
bjp-33625	148	4	an	an	DET
bjp-33625	148	5	integral	integral	ADJ
bjp-33625	148	6	part	part	NOUN
bjp-33625	148	7	of	of	ADP
bjp-33625	148	8	the	the	DET
bjp-33625	148	9	molecule	molecule	NOUN
bjp-33625	148	10	,	,	PUNCT
bjp-33625	148	11	where	where	SCONJ
bjp-33625	148	12	a	a	DET
bjp-33625	148	13	medicinal	medicinal	ADJ
bjp-33625	148	14	chemist	chemist	NOUN
bjp-33625	148	15	can	can	AUX
bjp-33625	148	16	try	try	VERB
bjp-33625	148	17	for	for	ADP
bjp-33625	148	18	structural	structural	ADJ
bjp-33625	148	19	alternation	alternation	NOUN
bjp-33625	148	20	to	to	PART
bjp-33625	148	21	extract	extract	VERB
bjp-33625	148	22	the	the	DET
bjp-33625	148	23	bioactivity	bioactivity	NOUN
bjp-33625	148	24	to	to	ADP
bjp-33625	148	25	the	the	DET
bjp-33625	148	26	molecule	molecule	NOUN
bjp-33625	148	27	in	in	ADP
bjp-33625	148	28	fullest	full	ADJ
bjp-33625	148	29	(	(	PUNCT
bjp-33625	148	30	mathew	mathew	PROPN
bjp-33625	148	31	et	et	PROPN
bjp-33625	148	32	al	al	PROPN
bjp-33625	148	33	.	.	PROPN
bjp-33625	148	34	,	,	PUNCT
bjp-33625	148	35	2010	2010	NUM
bjp-33625	148	36	)	)	PUNCT
bjp-33625	148	37	.	.	PUNCT
bjp-33625	149	1	the	the	DET
bjp-33625	149	2	docking	docking	NOUN
bjp-33625	149	3	interaction	interaction	NOUN
bjp-33625	149	4	describes	describe	VERB
bjp-33625	149	5	none	none	NOUN
bjp-33625	149	6	of	of	ADP
bjp-33625	149	7	the	the	DET
bjp-33625	149	8	cases	case	NOUN
bjp-33625	149	9	pyrazoline	pyrazoline	NOUN
bjp-33625	149	10	has	have	VERB
bjp-33625	149	11	much	much	ADJ
bjp-33625	149	12	interaction	interaction	NOUN
bjp-33625	149	13	with	with	ADP
bjp-33625	149	14	the	the	DET
bjp-33625	149	15	amino	amino	NOUN
bjp-33625	149	16	acid	acid	NOUN
bjp-33625	149	17	residues	residue	NOUN
bjp-33625	149	18	in	in	ADP
bjp-33625	149	19	enzyme	enzyme	NOUN
bjp-33625	149	20	binding	bind	VERB
bjp-33625	149	21	with	with	ADP
bjp-33625	149	22	it	it	PRON
bjp-33625	149	23	.	.	PUNCT
bjp-33625	150	1	whereas	whereas	SCONJ
bjp-33625	150	2	substitution	substitution	NOUN
bjp-33625	150	3	in	in	ADP
bjp-33625	150	4	pyrazoline	pyrazoline	NOUN
bjp-33625	150	5	with	with	ADP
bjp-33625	150	6	chloro	chloro	NOUN
bjp-33625	150	7	,	,	PUNCT
bjp-33625	150	8	fluoro	fluoro	NOUN
bjp-33625	150	9	,	,	PUNCT
bjp-33625	150	10	hydroxy	hydroxy	PROPN
bjp-33625	150	11	and	and	CCONJ
bjp-33625	150	12	cinnamoyl	cinnamoyl	PROPN
bjp-33625	150	13	group	group	NOUN
bjp-33625	150	14	found	find	VERB
bjp-33625	150	15	to	to	PART
bjp-33625	150	16	bring	bring	VERB
bjp-33625	150	17	a	a	DET
bjp-33625	150	18	lot	lot	NOUN
bjp-33625	150	19	of	of	ADP
bjp-33625	150	20	variations	variation	NOUN
bjp-33625	150	21	in	in	ADP
bjp-33625	150	22	binding	bind	VERB
bjp-33625	150	23	energies	energy	NOUN
bjp-33625	150	24	as	as	SCONJ
bjp-33625	150	25	discussed	discuss	VERB
bjp-33625	150	26	earlier	early	ADV
bjp-33625	150	27	.	.	PUNCT
bjp-33625	151	1	assessment	assessment	NOUN
bjp-33625	151	2	of	of	ADP
bjp-33625	151	3	the	the	DET
bjp-33625	151	4	predictive	predictive	ADJ
bjp-33625	151	5	accuracy	accuracy	NOUN
bjp-33625	151	6	of	of	ADP
bjp-33625	151	7	in	in	ADP
bjp-33625	151	8	silico	silico	NOUN
bjp-33625	151	9	prediction	prediction	NOUN
bjp-33625	151	10	tools	tool	NOUN
bjp-33625	151	11	,	,	PUNCT
bjp-33625	151	12	alone	alone	ADJ
bjp-33625	151	13	or	or	CCONJ
bjp-33625	151	14	in	in	ADP
bjp-33625	151	15	combination	combination	NOUN
bjp-33625	151	16	was	be	AUX
bjp-33625	151	17	tried	try	VERB
bjp-33625	151	18	by	by	ADP
bjp-33625	151	19	many	many	ADJ
bjp-33625	151	20	researchers	researcher	NOUN
bjp-33625	151	21	(	(	PUNCT
bjp-33625	151	22	leong	leong	PROPN
bjp-33625	151	23	et	et	PROPN
bjp-33625	151	24	al	al	PROPN
bjp-33625	151	25	.	.	PROPN
bjp-33625	151	26	,	,	PUNCT
bjp-33625	151	27	2015	2015	NUM
bjp-33625	151	28	)	)	PUNCT
bjp-33625	151	29	.	.	PUNCT
bjp-33625	152	1	the	the	DET
bjp-33625	152	2	uniqueness	uniqueness	NOUN
bjp-33625	152	3	of	of	ADP
bjp-33625	152	4	this	this	DET
bjp-33625	152	5	work	work	NOUN
bjp-33625	152	6	lies	lie	VERB
bjp-33625	152	7	with	with	ADP
bjp-33625	152	8	the	the	DET
bjp-33625	152	9	prediction	prediction	NOUN
bjp-33625	152	10	of	of	ADP
bjp-33625	152	11	a	a	DET
bjp-33625	152	12	scaffold	scaffold	NOUN
bjp-33625	152	13	in	in	ADP
bjp-33625	152	14	a	a	DET
bjp-33625	152	15	big	big	ADJ
bjp-33625	152	16	molecule	molecule	NOUN
bjp-33625	152	17	and	and	CCONJ
bjp-33625	152	18	its	its	PRON
bjp-33625	152	19	establishment	establishment	NOUN
bjp-33625	152	20	by	by	ADP
bjp-33625	152	21	using	use	VERB
bjp-33625	152	22	binding	bind	VERB
bjp-33625	152	23	configuration	configuration	NOUN
bjp-33625	152	24	obtained	obtain	VERB
bjp-33625	152	25	after	after	ADP
bjp-33625	152	26	docking	dock	VERB
bjp-33625	152	27	study	study	NOUN
bjp-33625	152	28	.	.	PUNCT
bjp-33625	153	1	the	the	DET
bjp-33625	153	2	lead	lead	ADJ
bjp-33625	153	3	optimization	optimization	NOUN
bjp-33625	153	4	techniques	technique	NOUN
bjp-33625	153	5	showed	show	VERB
bjp-33625	153	6	that	that	SCONJ
bjp-33625	153	7	the	the	DET
bjp-33625	153	8	compound	compound	NOUN
bjp-33625	153	9	code-3	code-3	VERB
bjp-33625	153	10	with	with	ADP
bjp-33625	153	11	hydroxyl	hydroxyl	NOUN
bjp-33625	153	12	substitution	substitution	NOUN
bjp-33625	153	13	showed	show	VERB
bjp-33625	153	14	good	good	ADJ
bjp-33625	153	15	drug	drug	NOUN
bjp-33625	153	16	likeness	likeness	NOUN
bjp-33625	153	17	and	and	CCONJ
bjp-33625	153	18	bioactivity	bioactivity	NOUN
bjp-33625	153	19	score	score	NOUN
bjp-33625	153	20	in	in	ADP
bjp-33625	153	21	the	the	DET
bjp-33625	153	22	initial	initial	ADJ
bjp-33625	153	23	level	level	NOUN
bjp-33625	153	24	of	of	ADP
bjp-33625	153	25	in	in	ADP
bjp-33625	153	26	silico	silico	NOUN
bjp-33625	153	27	screening	screen	VERB
bjp-33625	153	28	.	.	PUNCT
bjp-33625	154	1	further	far	ADV
bjp-33625	154	2	,	,	PUNCT
bjp-33625	154	3	the	the	DET
bjp-33625	154	4	same	same	ADJ
bjp-33625	154	5	molecule	molecule	NOUN
bjp-33625	154	6	showed	show	VERB
bjp-33625	154	7	good	good	ADJ
bjp-33625	154	8	binding	binding	NOUN
bjp-33625	154	9	to	to	ADP
bjp-33625	154	10	dihydrofolate	dihydrofolate	NOUN
bjp-33625	154	11	reductase	reductase	NOUN
bjp-33625	154	12	enzyme	enzyme	NOUN
bjp-33625	154	13	with	with	ADP
bjp-33625	154	14	stronger	strong	ADJ
bjp-33625	154	15	electrostatic	electrostatic	ADJ
bjp-33625	154	16	interaction	interaction	NOUN
bjp-33625	154	17	.	.	PUNCT
bjp-33625	155	1	in	in	ADP
bjp-33625	155	2	the	the	DET
bjp-33625	155	3	later	later	ADJ
bjp-33625	155	4	stage	stage	NOUN
bjp-33625	155	5	of	of	ADP
bjp-33625	155	6	work	work	NOUN
bjp-33625	155	7	,	,	PUNCT
bjp-33625	155	8	this	this	PRON
bjp-33625	155	9	in	in	ADP
bjp-33625	155	10	silico	silico	NOUN
bjp-33625	155	11	results	result	NOUN
bjp-33625	155	12	found	find	VERB
bjp-33625	155	13	matching	match	VERB
bjp-33625	155	14	with	with	ADP
bjp-33625	155	15	the	the	DET
bjp-33625	155	16	results	result	NOUN
bjp-33625	155	17	obtained	obtain	VERB
bjp-33625	155	18	from	from	ADP
bjp-33625	155	19	in	in	ADP
bjp-33625	155	20	vitro	vitro	X
bjp-33625	155	21	antimalarial	antimalarial	ADJ
bjp-33625	155	22	screening	screening	NOUN
bjp-33625	155	23	.	.	PUNCT
bjp-33625	156	1	it	it	PRON
bjp-33625	156	2	was	be	AUX
bjp-33625	156	3	interesting	interesting	ADJ
bjp-33625	156	4	to	to	PART
bjp-33625	156	5	note	note	VERB
bjp-33625	156	6	that	that	SCONJ
bjp-33625	156	7	hydroxy	hydroxy	PROPN
bjp-33625	156	8	derivative	derivative	NOUN
bjp-33625	156	9	showed	show	VERB
bjp-33625	156	10	good	good	ADJ
bjp-33625	156	11	binding	binding	NOUN
bjp-33625	156	12	to	to	ADP
bjp-33625	156	13	dihydrofolate	dihydrofolate	NOUN
bjp-33625	156	14	reductase	reductase	NOUN
bjp-33625	156	15	enzyme	enzyme	NOUN
bjp-33625	156	16	with	with	ADP
bjp-33625	156	17	prominent	prominent	ADJ
bjp-33625	156	18	electrostatic	electrostatic	ADJ
bjp-33625	156	19	interactions	interaction	NOUN
bjp-33625	156	20	.	.	PUNCT
bjp-33625	157	1	whereas	whereas	SCONJ
bjp-33625	157	2	the	the	DET
bjp-33625	157	3	other	other	ADJ
bjp-33625	157	4	molecule	molecule	NOUN
bjp-33625	157	5	,	,	PUNCT
bjp-33625	157	6	including	include	VERB
bjp-33625	157	7	the	the	DET
bjp-33625	157	8	standard	standard	ADJ
bjp-33625	157	9	drug	drug	NOUN
bjp-33625	157	10	,	,	PUNCT
bjp-33625	157	11	showed	show	VERB
bjp-33625	157	12	moderate	moderate	ADJ
bjp-33625	157	13	to	to	ADP
bjp-33625	157	14	weak	weak	ADJ
bjp-33625	157	15	van	van	PROPN
bjp-33625	157	16	der	der	ADJ
bjp-33625	157	17	walls	wall	NOUN
bjp-33625	157	18	type	type	NOUN
bjp-33625	157	19	of	of	ADP
bjp-33625	157	20	interactions	interaction	NOUN
bjp-33625	157	21	.	.	PUNCT
bjp-33625	158	1	further	far	ADV
bjp-33625	158	2	,	,	PUNCT
bjp-33625	158	3	the	the	DET
bjp-33625	158	4	optimum	optimum	ADJ
bjp-33625	158	5	hydrophilic	hydrophilic	ADJ
bjp-33625	158	6	-	-	PUNCT
bjp-33625	158	7	lipophilic	lipophilic	NOUN
bjp-33625	158	8	balance	balance	NOUN
bjp-33625	158	9	found	find	VERB
bjp-33625	158	10	to	to	PART
bjp-33625	158	11	exist	exist	VERB
bjp-33625	158	12	in	in	ADP
bjp-33625	158	13	molecule	molecule	NOUN
bjp-33625	158	14	contributes	contribute	VERB
bjp-33625	158	15	to	to	ADP
bjp-33625	158	16	strong	strong	ADJ
bjp-33625	158	17	receptor	receptor	NOUN
bjp-33625	158	18	binding	bind	VERB
bjp-33625	158	19	.	.	PUNCT
bjp-33625	159	1	table	table	NOUN
bjp-33625	159	2	ii	ii	PROPN
bjp-33625	159	3	statistical	statistical	ADJ
bjp-33625	159	4	docking	docking	NOUN
bjp-33625	159	5	results	result	NOUN
bjp-33625	159	6	of	of	ADP
bjp-33625	159	7	synthetic	synthetic	ADJ
bjp-33625	159	8	ligands	ligand	NOUN
bjp-33625	159	9	(	(	PUNCT
bjp-33625	159	10	discovery	discovery	NOUN
bjp-33625	159	11	studio	studio	NOUN
bjp-33625	159	12	3.5	3.5	NUM
bjp-33625	159	13	software	software	NOUN
bjp-33625	159	14	)	)	PUNCT
bjp-33625	159	15	compound	compound	NOUN
bjp-33625	159	16	code	code	PROPN
bjp-33625	159	17	cdocker	cdocker	PROPN
bjp-33625	159	18	energy	energy	NOUN
bjp-33625	159	19	cdocker	cdocker	NOUN
bjp-33625	159	20	interaction	interaction	NOUN
bjp-33625	159	21	energy	energy	NOUN
bjp-33625	159	22	nature	nature	NOUN
bjp-33625	159	23	of	of	ADP
bjp-33625	159	24	hydrogen	hydrogen	NOUN
bjp-33625	159	25	bond	bond	NOUN
bjp-33625	159	26	distance	distance	NOUN
bjp-33625	159	27	prominent	prominent	ADJ
bjp-33625	159	28	type	type	NOUN
bjp-33625	159	29	of	of	ADP
bjp-33625	159	30	interaction	interaction	NOUN
bjp-33625	159	31	1	1	NUM
bjp-33625	159	32	18.5	18.5	NUM
bjp-33625	159	33	48.3	48.3	NUM
bjp-33625	159	34	van	van	PROPN
bjp-33625	159	35	der	der	NOUN
bjp-33625	159	36	waals	waal	NOUN
bjp-33625	159	37	2	2	NUM
bjp-33625	159	38	6.2	6.2	NUM
bjp-33625	159	39	35.9	35.9	NUM
bjp-33625	159	40	a	a	DET
bjp-33625	159	41	:	:	PUNCT
bjp-33625	159	42	ser49mol	ser49mol	NOUN
bjp-33625	159	43	:	:	PUNCT
bjp-33625	159	44	o16	o16	VERB
bjp-33625	159	45	a	a	DET
bjp-33625	159	46	:	:	PUNCT
bjp-33625	159	47	thr46mol	thr46mol	PROPN
bjp-33625	159	48	:	:	PUNCT
bjp-33625	159	49	n7	n7	PROPN
bjp-33625	159	50	2.3	2.3	NUM
bjp-33625	159	51	2.0	2.0	NUM
bjp-33625	159	52	van	van	PROPN
bjp-33625	159	53	der	der	NOUN
bjp-33625	159	54	waals	waal	NOUN
bjp-33625	159	55	3	3	NUM
bjp-33625	159	56	23.3	23.3	NUM
bjp-33625	159	57	53.4	53.4	NUM
bjp-33625	159	58	a	a	DET
bjp-33625	159	59	:	:	PUNCT
bjp-33625	159	60	thr46mol	thr46mol	PROPN
bjp-33625	159	61	:	:	PUNCT
bjp-33625	159	62	n7	n7	PROPN
bjp-33625	159	63	a	a	DET
bjp-33625	159	64	:	:	PUNCT
bjp-33625	159	65	ser49	ser49	NOUN
bjp-33625	159	66	-	-	PUNCT
bjp-33625	159	67	mol	mol	ADP
bjp-33625	159	68	:	:	PUNCT
bjp-33625	159	69	o16	o16	PROPN
bjp-33625	159	70	mol	mol	PROPN
bjp-33625	159	71	:	:	PUNCT
bjp-33625	159	72	h51	h51	VERB
bjp-33625	159	73	a	a	PROPN
bjp-33625	159	74	-	-	PUNCT
bjp-33625	159	75	tyr100	tyr100	NOUN
bjp-33625	159	76	:	:	PUNCT
bjp-33625	159	77	oh	oh	NUM
bjp-33625	159	78	2.0	2.0	NUM
bjp-33625	159	79	2.4	2.4	NUM
bjp-33625	159	80	1.9	1.9	NUM
bjp-33625	159	81	electrostatic	electrostatic	ADJ
bjp-33625	159	82	4	4	NUM
bjp-33625	159	83	10.3	10.3	NUM
bjp-33625	159	84	39.4	39.4	NUM
bjp-33625	159	85	a	a	DET
bjp-33625	159	86	:	:	PUNCT
bjp-33625	159	87	ala7	ala7	NOUN
bjp-33625	159	88	:	:	PUNCT
bjp-33625	159	89	hn	hn	PROPN
bjp-33625	159	90	-mol	-mol	PROPN
bjp-33625	159	91	:	:	PUNCT
bjp-33625	159	92	o33	o33	PROPN
bjp-33625	159	93	2.3	2.3	NUM
bjp-33625	159	94	van	van	PROPN
bjp-33625	159	95	der	der	NOUN
bjp-33625	159	96	waals	waal	NOUN
bjp-33625	159	97	standard	standard	VERB
bjp-33625	159	98	37.0	37.0	NUM
bjp-33625	159	99	62.9	62.9	NUM
bjp-33625	159	100	mol	mol	NOUN
bjp-33625	159	101	:	:	PUNCT
bjp-33625	159	102	h48	h48	VERB
bjp-33625	159	103	a	a	DET
bjp-33625	159	104	:	:	PUNCT
bjp-33625	159	105	glu17	glu17	NOUN
bjp-33625	159	106	:o	:o	PROPN
bjp-33625	159	107	mol	mol	PROPN
bjp-33625	159	108	:	:	PUNCT
bjp-33625	159	109	h48	h48	VERB
bjp-33625	159	110	a	a	DET
bjp-33625	159	111	:	:	PUNCT
bjp-33625	159	112	asp122	asp122	PROPN
bjp-33625	159	113	:	:	PUNCT
bjp-33625	159	114	od	od	PROPN
bjp-33625	159	115	mol	mol	PROPN
bjp-33625	159	116	:	:	PUNCT
bjp-33625	159	117	h50	h50	PROPN
bjp-33625	159	118	a	a	DET
bjp-33625	159	119	:	:	PUNCT
bjp-33625	159	120	tyr100	tyr100	NOUN
bjp-33625	159	121	:	:	PUNCT
bjp-33625	159	122	oh	oh	NUM
bjp-33625	159	123	2.4	2.4	NUM
bjp-33625	159	124	2.4	2.4	NUM
bjp-33625	159	125	2.0	2.0	NUM
bjp-33625	159	126	van	van	PROPN
bjp-33625	159	127	der	der	NOUN
bjp-33625	159	128	waals	waal	NOUN
bjp-33625	159	129	table	table	VERB
bjp-33625	159	130	iii	iii	NOUN
bjp-33625	159	131	in	in	X
bjp-33625	159	132	vitro	vitro	X
bjp-33625	159	133	antimalarial	antimalarial	ADJ
bjp-33625	159	134	assay	assay	NOUN
bjp-33625	159	135	of	of	ADP
bjp-33625	159	136	synthesized	synthesize	VERB
bjp-33625	159	137	ligands	ligand	NOUN
bjp-33625	159	138	sample	sample	NOUN
bjp-33625	159	139	code	code	NOUN
bjp-33625	159	140	%	%	NOUN
bjp-33625	159	141	dead	dead	ADJ
bjp-33625	159	142	parasites	parasite	NOUN
bjp-33625	159	143	(	(	PUNCT
bjp-33625	159	144	rings	ring	NOUN
bjp-33625	159	145	+	+	CCONJ
bjp-33625	159	146	trophozoites	trophozoite	NOUN
bjp-33625	159	147	+	+	CCONJ
bjp-33625	159	148	schizont	schizont	ADJ
bjp-33625	159	149	)	)	PUNCT
bjp-33625	159	150	5	5	NUM
bjp-33625	159	151	µg	µg	NOUN
bjp-33625	159	152	/	/	SYM
bjp-33625	159	153	ml	ml	PROPN
bjp-33625	159	154	50	50	NUM
bjp-33625	159	155	µg	µg	NOUN
bjp-33625	159	156	/	/	SYM
bjp-33625	159	157	ml	ml	NOUN
bjp-33625	159	158	1	1	NUM
bjp-33625	159	159	0	0	NUM
bjp-33625	159	160	25	25	NUM
bjp-33625	159	161	2	2	NUM
bjp-33625	159	162	0	0	NUM
bjp-33625	159	163	37	37	NUM
bjp-33625	159	164	3	3	NUM
bjp-33625	159	165	0	0	NUM
bjp-33625	159	166	38	38	NUM
bjp-33625	159	167	4	4	NUM
bjp-33625	159	168	0	0	NUM
bjp-33625	159	169	29	29	NUM
bjp-33625	159	170	chloroquine	chloroquine	NOUN
bjp-33625	159	171	46	46	NUM
bjp-33625	159	172	28	28	NUM
bjp-33625	159	173	bangladesh	bangladesh	PROPN
bjp-33625	159	174	j	j	PROPN
bjp-33625	159	175	pharmacol	pharmacol	PROPN
bjp-33625	159	176	2018	2018	NUM
bjp-33625	159	177	;	;	PUNCT
bjp-33625	159	178	13	13	NUM
bjp-33625	159	179	:	:	SYM
bjp-33625	159	180	23	23	NUM
bjp-33625	159	181	-	-	SYM
bjp-33625	159	182	29	29	NUM
bjp-33625	159	183	author	author	NOUN
bjp-33625	159	184	info	info	NOUN
bjp-33625	159	185	krishnakumar	krishnakumar	PROPN
bjp-33625	159	186	lohidakshan	lohidakshan	PROPN
bjp-33625	159	187	(	(	PUNCT
bjp-33625	159	188	principal	principal	ADJ
bjp-33625	159	189	contact	contact	NOUN
bjp-33625	159	190	)	)	PUNCT
bjp-33625	160	1	e	e	NOUN
bjp-33625	160	2	-	-	NOUN
bjp-33625	160	3	mail	mail	NOUN
bjp-33625	160	4	:	:	PUNCT
bjp-33625	160	5	krishnakumarkl@acharya.ac.in	krishnakumarkl@acharya.ac.in	X
bjp-33625	160	6	conclusion	conclusion	VERB
bjp-33625	160	7	the	the	DET
bjp-33625	160	8	extended	extended	ADJ
bjp-33625	160	9	lipophilicity	lipophilicity	NOUN
bjp-33625	160	10	and	and	CCONJ
bjp-33625	160	11	stronger	strong	ADJ
bjp-33625	160	12	electrostatic	electrostatic	ADJ
bjp-33625	160	13	interaction	interaction	NOUN
bjp-33625	160	14	may	may	AUX
bjp-33625	160	15	be	be	AUX
bjp-33625	160	16	a	a	DET
bjp-33625	160	17	reason	reason	NOUN
bjp-33625	160	18	for	for	ADP
bjp-33625	160	19	this	this	DET
bjp-33625	160	20	lead	lead	NOUN
bjp-33625	160	21	compound	compound	NOUN
bjp-33625	160	22	to	to	PART
bjp-33625	160	23	exhibit	exhibit	VERB
bjp-33625	160	24	significant	significant	ADJ
bjp-33625	160	25	pharmacological	pharmacological	ADJ
bjp-33625	160	26	action	action	NOUN
bjp-33625	160	27	.	.	PUNCT
bjp-33625	161	1	acknowledgement	acknowledgement	NOUN
bjp-33625	161	2	authors	author	NOUN
bjp-33625	161	3	are	be	AUX
bjp-33625	161	4	thankful	thankful	ADJ
bjp-33625	161	5	to	to	ADP
bjp-33625	161	6	the	the	DET
bjp-33625	161	7	management	management	NOUN
bjp-33625	161	8	of	of	ADP
bjp-33625	161	9	acharya	acharya	PROPN
bjp-33625	161	10	and	and	CCONJ
bjp-33625	161	11	b.	b.	PROPN
bjp-33625	161	12	m.	m.	PROPN
bjp-33625	161	13	reddy	reddy	PROPN
bjp-33625	161	14	college	college	PROPN
bjp-33625	161	15	of	of	ADP
bjp-33625	161	16	pharmacy	pharmacy	PROPN
bjp-33625	161	17	,	,	PUNCT
bjp-33625	161	18	bengaluru	bengaluru	PROPN
bjp-33625	161	19	,	,	PUNCT
bjp-33625	161	20	cochin	cochin	PROPN
bjp-33625	161	21	university	university	PROPN
bjp-33625	161	22	of	of	ADP
bjp-33625	161	23	science	science	NOUN
bjp-33625	161	24	and	and	CCONJ
bjp-33625	161	25	technology	technology	NOUN
bjp-33625	161	26	,	,	PUNCT
bjp-33625	161	27	kerala	kerala	PROPN
bjp-33625	161	28	and	and	CCONJ
bjp-33625	161	29	nirmala	nirmala	PROPN
bjp-33625	161	30	college	college	PROPN
bjp-33625	161	31	of	of	ADP
bjp-33625	161	32	health	health	PROPN
bjp-33625	161	33	science	science	NOUN
bjp-33625	161	34	,	,	PUNCT
bjp-33625	161	35	kerala	kerala	NOUN
bjp-33625	161	36	for	for	ADP
bjp-33625	161	37	providing	provide	VERB
bjp-33625	161	38	necessary	necessary	ADJ
bjp-33625	161	39	facilities	facility	NOUN
bjp-33625	161	40	to	to	PART
bjp-33625	161	41	carry	carry	VERB
bjp-33625	161	42	out	out	ADP
bjp-33625	161	43	this	this	DET
bjp-33625	161	44	work	work	NOUN
bjp-33625	161	45	successfully	successfully	ADV
bjp-33625	161	46	.	.	PUNCT
bjp-33625	162	1	references	reference	NOUN
bjp-33625	162	2	akhtar	akhtar	PROPN
bjp-33625	162	3	j	j	PROPN
bjp-33625	162	4	,	,	PUNCT
bjp-33625	162	5	khan	khan	PROPN
bjp-33625	162	6	aa	aa	PROPN
bjp-33625	162	7	,	,	PUNCT
bjp-33625	162	8	ali	ali	PROPN
bjp-33625	162	9	z	z	PROPN
bjp-33625	162	10	,	,	PUNCT
bjp-33625	162	11	haider	haider	PROPN
bjp-33625	162	12	r	r	PROPN
bjp-33625	162	13	,	,	PUNCT
bjp-33625	162	14	yar	yar	PROPN
bjp-33625	162	15	ms	ms	PROPN
bjp-33625	162	16	.	.	PROPN
bjp-33625	162	17	structure	structure	NOUN
bjp-33625	162	18	-	-	PUNCT
bjp-33625	162	19	activity	activity	NOUN
bjp-33625	162	20	relationship	relationship	NOUN
bjp-33625	162	21	(	(	PUNCT
bjp-33625	162	22	sar	sar	NOUN
bjp-33625	162	23	)	)	PUNCT
bjp-33625	162	24	study	study	NOUN
bjp-33625	162	25	and	and	CCONJ
bjp-33625	162	26	design	design	NOUN
bjp-33625	162	27	strategies	strategy	NOUN
bjp-33625	162	28	of	of	ADP
bjp-33625	162	29	nitrogencontaining	nitrogencontaine	VERB
bjp-33625	162	30	heterocyclic	heterocyclic	ADJ
bjp-33625	162	31	moieties	moiety	NOUN
bjp-33625	162	32	for	for	ADP
bjp-33625	162	33	their	their	PRON
bjp-33625	162	34	anti	anti	ADJ
bjp-33625	162	35	-	-	ADJ
bjp-33625	162	36	cancer	cancer	ADJ
bjp-33625	162	37	activities	activity	NOUN
bjp-33625	162	38	.	.	PUNCT
bjp-33625	163	1	eur	eur	PROPN
bjp-33625	163	2	j	j	PROPN
bjp-33625	163	3	med	med	PROPN
bjp-33625	163	4	chem	chem	NOUN
bjp-33625	163	5	.	.	PUNCT
bjp-33625	164	1	2017	2017	NUM
bjp-33625	164	2	;	;	PUNCT
bjp-33625	164	3	125	125	NUM
bjp-33625	164	4	:	:	PUNCT
bjp-33625	164	5	143	143	NUM
bjp-33625	164	6	-	-	SYM
bjp-33625	164	7	89	89	NUM
bjp-33625	164	8	.	.	PUNCT
bjp-33625	165	1	daina	daina	PROPN
bjp-33625	165	2	a	a	PROPN
bjp-33625	165	3	,	,	PUNCT
bjp-33625	165	4	michielin	michielin	PROPN
bjp-33625	165	5	o	o	NOUN
bjp-33625	165	6	,	,	PUNCT
bjp-33625	165	7	zoete	zoete	PROPN
bjp-33625	165	8	v.	v.	ADP
bjp-33625	165	9	swiss	swiss	PROPN
bjp-33625	165	10	adme	adme	NOUN
bjp-33625	165	11	:	:	PUNCT
bjp-33625	165	12	a	a	DET
bjp-33625	165	13	free	free	ADJ
bjp-33625	165	14	web	web	NOUN
bjp-33625	165	15	tool	tool	NOUN
bjp-33625	165	16	to	to	PART
bjp-33625	165	17	evaluate	evaluate	VERB
bjp-33625	165	18	pharmacokinetics	pharmacokinetic	NOUN
bjp-33625	165	19	,	,	PUNCT
bjp-33625	165	20	drug	drug	NOUN
bjp-33625	165	21	-	-	PUNCT
bjp-33625	165	22	likeness	likeness	NOUN
bjp-33625	165	23	and	and	CCONJ
bjp-33625	165	24	medicinal	medicinal	ADJ
bjp-33625	165	25	chemistry	chemistry	NOUN
bjp-33625	165	26	friendliness	friendliness	NOUN
bjp-33625	165	27	of	of	ADP
bjp-33625	165	28	small	small	ADJ
bjp-33625	165	29	molecules	molecule	NOUN
bjp-33625	165	30	.	.	PUNCT
bjp-33625	166	1	sci	sci	PROPN
bjp-33625	166	2	rep	rep	PROPN
bjp-33625	166	3	.	.	PROPN
bjp-33625	166	4	2017	2017	NUM
bjp-33625	166	5	;	;	PUNCT
bjp-33625	166	6	7	7	NUM
bjp-33625	166	7	:	:	SYM
bjp-33625	166	8	42717	42717	NUM
bjp-33625	166	9	.	.	PUNCT
bjp-33625	167	1	doak	doak	PROPN
bjp-33625	167	2	bc	bc	PROPN
bjp-33625	167	3	,	,	PUNCT
bjp-33625	167	4	over	over	ADP
bjp-33625	167	5	b	b	NUM
bjp-33625	167	6	,	,	PUNCT
bjp-33625	167	7	giordanetto	giordanetto	PROPN
bjp-33625	167	8	f	f	PROPN
bjp-33625	167	9	,	,	PUNCT
bjp-33625	167	10	kihlberg	kihlberg	PROPN
bjp-33625	167	11	j.	j.	PROPN
bjp-33625	167	12	oral	oral	PROPN
bjp-33625	167	13	druggable	druggable	ADJ
bjp-33625	167	14	space	space	NOUN
bjp-33625	167	15	beyond	beyond	ADP
bjp-33625	167	16	the	the	DET
bjp-33625	167	17	rule	rule	NOUN
bjp-33625	167	18	of	of	ADP
bjp-33625	167	19	5	5	NUM
bjp-33625	167	20	:	:	PUNCT
bjp-33625	167	21	insights	insight	NOUN
bjp-33625	167	22	from	from	ADP
bjp-33625	167	23	drugs	drug	NOUN
bjp-33625	167	24	and	and	CCONJ
bjp-33625	167	25	clinical	clinical	ADJ
bjp-33625	167	26	candidates	candidate	NOUN
bjp-33625	167	27	.	.	PUNCT
bjp-33625	168	1	chem	chem	NOUN
bjp-33625	168	2	biol	biol	PROPN
bjp-33625	168	3	.	.	PUNCT
bjp-33625	169	1	2014	2014	NUM
bjp-33625	169	2	;	;	PUNCT
bjp-33625	169	3	21	21	NUM
bjp-33625	169	4	:	:	SYM
bjp-33625	169	5	1115	1115	NUM
bjp-33625	169	6	-	-	SYM
bjp-33625	169	7	42	42	NUM
bjp-33625	169	8	.	.	PUNCT
bjp-33625	170	1	havaldar	havaldar	PROPN
bjp-33625	170	2	fh	fh	PROPN
bjp-33625	170	3	,	,	PUNCT
bjp-33625	170	4	patil	patil	PROPN
bjp-33625	170	5	ar	ar	PROPN
bjp-33625	170	6	.	.	PROPN
bjp-33625	170	7	synthesis	synthesis	NOUN
bjp-33625	170	8	of	of	ADP
bjp-33625	170	9	biologically	biologically	ADV
bjp-33625	170	10	active	active	ADJ
bjp-33625	170	11	1-[2-(2methyl-5	1-[2-(2methyl-5	NUM
bjp-33625	170	12	-	-	PUNCT
bjp-33625	170	13	nitroimidazole-1	nitroimidazole-1	NUM
bjp-33625	170	14	-	-	PUNCT
bjp-33625	170	15	yl)acetyl]-3	yl)acetyl]-3	NOUN
bjp-33625	170	16	-	-	PUNCT
bjp-33625	170	17	substituted	substitute	VERB
bjp-33625	170	18	phenyl-4carbaldehyde-1h	phenyl-4carbaldehyde-1h	NOUN
bjp-33625	170	19	-	-	PUNCT
bjp-33625	170	20	pyrazoles	pyrazoles	PROPN
bjp-33625	170	21	.	.	PUNCT
bjp-33625	171	1	asian	asian	PROPN
bjp-33625	171	2	j	j	PROPN
bjp-33625	171	3	chem	chem	NOUN
bjp-33625	171	4	.	.	PUNCT
bjp-33625	172	1	2008	2008	NUM
bjp-33625	172	2	;	;	PUNCT
bjp-33625	173	1	20	20	NUM
bjp-33625	173	2	:	:	SYM
bjp-33625	173	3	97	97	NUM
bjp-33625	173	4	-	-	SYM
bjp-33625	173	5	101	101	NUM
bjp-33625	173	6	.	.	PUNCT
bjp-33625	173	7	krishnakumar	krishnakumar	PROPN
bjp-33625	173	8	kl	kl	PROPN
bjp-33625	173	9	,	,	PUNCT
bjp-33625	173	10	mathew	mathew	PROPN
bjp-33625	173	11	pu	pu	PROPN
bjp-33625	173	12	,	,	PUNCT
bjp-33625	173	13	manju	manju	PROPN
bjp-33625	173	14	r.	r.	PROPN
bjp-33625	173	15	a	a	DET
bjp-33625	173	16	study	study	NOUN
bjp-33625	173	17	on	on	ADP
bjp-33625	173	18	effect	effect	NOUN
bjp-33625	173	19	of	of	ADP
bjp-33625	173	20	indole	indole	NOUN
bjp-33625	173	21	as	as	ADP
bjp-33625	173	22	a	a	DET
bjp-33625	173	23	substituent	substituent	NOUN
bjp-33625	173	24	on	on	ADP
bjp-33625	173	25	keto	keto	NOUN
bjp-33625	173	26	-	-	PUNCT
bjp-33625	173	27	enol	enol	NOUN
bjp-33625	173	28	tautomer	tautomer	NOUN
bjp-33625	173	29	:	:	PUNCT
bjp-33625	173	30	a	a	DET
bjp-33625	173	31	synthetic	synthetic	ADJ
bjp-33625	173	32	approach	approach	NOUN
bjp-33625	173	33	on	on	ADP
bjp-33625	173	34	β	β	NOUN
bjp-33625	173	35	-	-	NOUN
bjp-33625	173	36	diketone	diketone	NOUN
bjp-33625	173	37	.	.	PUNCT
bjp-33625	174	1	int	int	PROPN
bjp-33625	174	2	j	j	PROPN
bjp-33625	174	3	pharm	pharm	PROPN
bjp-33625	174	4	pharm	pharm	PROPN
bjp-33625	174	5	sci	sci	PROPN
bjp-33625	174	6	.	.	PROPN
bjp-33625	174	7	2017	2017	NUM
bjp-33625	174	8	;	;	PUNCT
bjp-33625	174	9	8	8	NUM
bjp-33625	174	10	:	:	SYM
bjp-33625	174	11	21924	21924	NUM
bjp-33625	174	12	.	.	PUNCT
bjp-33625	175	1	lee	lee	PROPN
bjp-33625	175	2	sh	sh	PROPN
bjp-33625	175	3	,	,	PUNCT
bjp-33625	175	4	kara	kara	PROPN
bjp-33625	175	5	e	e	PROPN
bjp-33625	175	6	,	,	PUNCT
bjp-33625	175	7	lee	lee	PROPN
bjp-33625	175	8	ma	ma	PROPN
bjp-33625	175	9	,	,	PUNCT
bjp-33625	175	10	lam	lam	PROPN
bjp-33625	175	11	s	s	PROPN
bjp-33625	175	12	,	,	PUNCT
bjp-33625	175	13	teo	teo	PROPN
bjp-33625	175	14	d.	d.	PROPN
bjp-33625	175	15	new	new	ADJ
bjp-33625	175	16	strategies	strategy	NOUN
bjp-33625	175	17	for	for	ADP
bjp-33625	175	18	the	the	DET
bjp-33625	175	19	diagnosis	diagnosis	NOUN
bjp-33625	175	20	and	and	CCONJ
bjp-33625	175	21	screening	screening	NOUN
bjp-33625	175	22	of	of	ADP
bjp-33625	175	23	malaria	malaria	NOUN
bjp-33625	175	24	.	.	PUNCT
bjp-33625	176	1	int	int	NOUN
bjp-33625	176	2	j	j	PROPN
bjp-33625	176	3	hematol	hematol	NOUN
bjp-33625	176	4	.	.	PUNCT
bjp-33625	177	1	2002	2002	NUM
bjp-33625	177	2	;	;	PUNCT
bjp-33625	177	3	1	1	NUM
bjp-33625	177	4	:	:	SYM
bjp-33625	177	5	291	291	NUM
bjp-33625	177	6	-	-	SYM
bjp-33625	177	7	93	93	NUM
bjp-33625	177	8	.	.	PUNCT
bjp-33625	178	1	leong	leong	PROPN
bjp-33625	178	2	iu	iu	PROPN
bjp-33625	178	3	,	,	PUNCT
bjp-33625	178	4	stuckeya	stuckeya	PROPN
bjp-33625	178	5	,	,	PUNCT
bjp-33625	178	6	lai	lai	PROPN
bjp-33625	178	7	d	d	PROPN
bjp-33625	178	8	,	,	PUNCT
bjp-33625	178	9	skinner	skinner	PROPN
bjp-33625	178	10	jr	jr	PROPN
bjp-33625	178	11	,	,	PUNCT
bjp-33625	178	12	love	love	PROPN
bjp-33625	178	13	dr	dr	PROPN
bjp-33625	178	14	.	.	PROPN
bjp-33625	178	15	assessment	assessment	NOUN
bjp-33625	178	16	of	of	ADP
bjp-33625	178	17	the	the	DET
bjp-33625	178	18	predictive	predictive	ADJ
bjp-33625	178	19	accuracy	accuracy	NOUN
bjp-33625	178	20	of	of	ADP
bjp-33625	178	21	five	five	NUM
bjp-33625	178	22	in	in	ADP
bjp-33625	178	23	silico	silico	NOUN
bjp-33625	178	24	prediction	prediction	NOUN
bjp-33625	178	25	tools	tool	NOUN
bjp-33625	178	26	,	,	PUNCT
bjp-33625	178	27	alone	alone	ADJ
bjp-33625	178	28	or	or	CCONJ
bjp-33625	178	29	in	in	ADP
bjp-33625	178	30	combination	combination	NOUN
bjp-33625	178	31	,	,	PUNCT
bjp-33625	178	32	and	and	CCONJ
bjp-33625	178	33	two	two	NUM
bjp-33625	178	34	metaservers	metaserver	NOUN
bjp-33625	178	35	to	to	PART
bjp-33625	178	36	classify	classify	VERB
bjp-33625	178	37	long	long	ADJ
bjp-33625	178	38	qt	qt	NOUN
bjp-33625	178	39	syndrome	syndrome	NOUN
bjp-33625	178	40	gene	gene	NOUN
bjp-33625	178	41	mutations	mutation	NOUN
bjp-33625	178	42	.	.	PUNCT
bjp-33625	179	1	bmc	bmc	PROPN
bjp-33625	179	2	med	med	ADJ
bjp-33625	179	3	genet	genet	NOUN
bjp-33625	179	4	.	.	PUNCT
bjp-33625	180	1	2015	2015	NUM
bjp-33625	180	2	;	;	PUNCT
bjp-33625	180	3	16	16	NUM
bjp-33625	180	4	:	:	SYM
bjp-33625	180	5	1	1	NUM
bjp-33625	180	6	-	-	SYM
bjp-33625	180	7	13	13	NUM
bjp-33625	180	8	.	.	PUNCT
bjp-33625	181	1	mabkhot	mabkhot	PROPN
bjp-33625	181	2	yn	yn	PROPN
bjp-33625	181	3	,	,	PUNCT
bjp-33625	181	4	barakat	barakat	PROPN
bjp-33625	181	5	a	a	PROPN
bjp-33625	181	6	,	,	PUNCT
bjp-33625	181	7	yousuf	yousuf	PROPN
bjp-33625	181	8	s	s	PROPN
bjp-33625	181	9	,	,	PUNCT
bjp-33625	181	10	choudhary	choudhary	PROPN
bjp-33625	181	11	mi	mi	PROPN
bjp-33625	181	12	,	,	PUNCT
bjp-33625	181	13	frey	frey	PROPN
bjp-33625	181	14	w	w	PROPN
bjp-33625	181	15	,	,	PUNCT
bjp-33625	181	16	hadda	hadda	NOUN
bjp-33625	181	17	tb	tb	X
bjp-33625	181	18	,	,	PUNCT
bjp-33625	181	19	mubarak	mubarak	PROPN
bjp-33625	181	20	ms	ms	PROPN
bjp-33625	181	21	.	.	PROPN
bjp-33625	181	22	substituted	substitute	VERB
bjp-33625	181	23	thieno	thieno	NOUN
bjp-33625	182	1	[	[	X
bjp-33625	182	2	2,3	2,3	NUM
bjp-33625	182	3	-	-	SYM
bjp-33625	182	4	b	b	NOUN
bjp-33625	182	5	]	]	PUNCT
bjp-33625	182	6	thiophenes	thiophene	NOUN
bjp-33625	182	7	and	and	CCONJ
bjp-33625	182	8	related	related	ADJ
bjp-33625	182	9	congeners	congener	NOUN
bjp-33625	182	10	:	:	PUNCT
bjp-33625	182	11	synthesis	synthesis	NOUN
bjp-33625	182	12	,	,	PUNCT
bjp-33625	182	13	β	β	X
bjp-33625	182	14	-	-	ADJ
bjp-33625	182	15	glucuronidase	glucuronidase	ADJ
bjp-33625	182	16	inhibition	inhibition	NOUN
bjp-33625	182	17	activity	activity	NOUN
bjp-33625	182	18	,	,	PUNCT
bjp-33625	182	19	crystal	crystal	NOUN
bjp-33625	182	20	structure	structure	NOUN
bjp-33625	182	21	,	,	PUNCT
bjp-33625	182	22	and	and	CCONJ
bjp-33625	182	23	pom	pom	NOUN
bjp-33625	182	24	analyses	analysis	NOUN
bjp-33625	182	25	.	.	PUNCT
bjp-33625	183	1	bioorg	bioorg	PROPN
bjp-33625	183	2	med	med	PROPN
bjp-33625	183	3	chem	chem	NOUN
bjp-33625	183	4	.	.	PUNCT
bjp-33625	184	1	2014	2014	NUM
bjp-33625	184	2	;	;	PUNCT
bjp-33625	184	3	23	23	NUM
bjp-33625	184	4	:	:	PUNCT
bjp-33625	184	5	6715	6715	NUM
bjp-33625	184	6	-	-	SYM
bjp-33625	184	7	25	25	NUM
bjp-33625	184	8	.	.	PUNCT
bjp-33625	185	1	mathew	mathew	PROPN
bjp-33625	185	2	ew	ew	PROPN
bjp-33625	185	3	,	,	PUNCT
bjp-33625	185	4	scott	scott	PROPN
bjp-33625	185	5	as	as	ADP
bjp-33625	185	6	,	,	PUNCT
bjp-33625	185	7	brent	brent	PROPN
bjp-33625	185	8	rs	rs	PROPN
bjp-33625	185	9	.	.	PUNCT
bjp-33625	186	1	privileged	privileged	ADJ
bjp-33625	186	2	scaffolds	scaffold	NOUN
bjp-33625	186	3	for	for	ADP
bjp-33625	186	4	library	library	NOUN
bjp-33625	186	5	design	design	NOUN
bjp-33625	186	6	and	and	CCONJ
bjp-33625	186	7	drug	drug	NOUN
bjp-33625	186	8	discovery	discovery	NOUN
bjp-33625	186	9	.	.	PUNCT
bjp-33625	187	1	curr	curr	PROPN
bjp-33625	187	2	opin	opin	NOUN
bjp-33625	187	3	chem	chem	NOUN
bjp-33625	187	4	biol	biol	NOUN
bjp-33625	187	5	.	.	PUNCT
bjp-33625	188	1	2010	2010	NUM
bjp-33625	188	2	;	;	PUNCT
bjp-33625	188	3	14	14	NUM
bjp-33625	188	4	:	:	SYM
bjp-33625	188	5	347	347	NUM
bjp-33625	188	6	-	-	SYM
bjp-33625	188	7	61	61	NUM
bjp-33625	188	8	.	.	PUNCT
bjp-33625	188	9	nyati	nyati	PROPN
bjp-33625	188	10	m	m	PROPN
bjp-33625	188	11	,	,	PUNCT
bjp-33625	188	12	rao	rao	PROPN
bjp-33625	188	13	ns	ns	NUM
bjp-33625	188	14	,	,	PUNCT
bjp-33625	188	15	srivastava	srivastava	PROPN
bjp-33625	188	16	yk	yk	PROPN
bjp-33625	188	17	,	,	PUNCT
bjp-33625	188	18	verma	verma	PROPN
bjp-33625	188	19	bl	bl	PROPN
bjp-33625	188	20	.	.	PUNCT
bjp-33625	189	1	synthesis	synthesis	NOUN
bjp-33625	189	2	of	of	ADP
bjp-33625	189	3	some	some	DET
bjp-33625	189	4	benzinidazolyl	benzinidazolyl	PROPN
bjp-33625	189	5	chalcones	chalcone	NOUN
bjp-33625	189	6	.	.	PUNCT
bjp-33625	190	1	asian	asian	PROPN
bjp-33625	190	2	j	j	PROPN
bjp-33625	190	3	chem	chem	NOUN
bjp-33625	190	4	.	.	PUNCT
bjp-33625	191	1	2006	2006	NUM
bjp-33625	191	2	;	;	PUNCT
bjp-33625	191	3	1	1	NUM
bjp-33625	191	4	:	:	PUNCT
bjp-33625	191	5	757	757	PROPN
bjp-33625	191	6	-	-	SYM
bjp-33625	191	7	59	59	NUM
bjp-33625	191	8	.	.	PUNCT
bjp-33625	191	9	parasuraman	parasuraman	PROPN
bjp-33625	191	10	s.	s.	PROPN
bjp-33625	191	11	prediction	prediction	NOUN
bjp-33625	191	12	of	of	ADP
bjp-33625	191	13	activity	activity	NOUN
bjp-33625	191	14	spectra	spectra	NOUN
bjp-33625	191	15	for	for	ADP
bjp-33625	191	16	substances	substance	NOUN
bjp-33625	191	17	.	.	PUNCT
bjp-33625	192	1	j	j	PROPN
bjp-33625	192	2	pharmacol	pharmacol	PROPN
bjp-33625	192	3	pharmacother	pharmacother	PROPN
bjp-33625	192	4	.	.	PUNCT
bjp-33625	193	1	2011	2011	NUM
bjp-33625	193	2	;	;	PUNCT
bjp-33625	193	3	2	2	NUM
bjp-33625	193	4	:	:	SYM
bjp-33625	193	5	52	52	NUM
bjp-33625	193	6	-	-	SYM
bjp-33625	193	7	53	53	NUM
bjp-33625	193	8	.	.	PUNCT
bjp-33625	194	1	patel	patel	PROPN
bjp-33625	194	2	gb	gb	PROPN
bjp-33625	194	3	,	,	PUNCT
bjp-33625	194	4	mahire	mahire	NOUN
bjp-33625	194	5	rr	rr	NOUN
bjp-33625	194	6	,	,	PUNCT
bjp-33625	194	7	more	more	ADJ
bjp-33625	194	8	dh	dh	NOUN
bjp-33625	194	9	.	.	PUNCT
bjp-33625	194	10	synthesis	synthesis	NOUN
bjp-33625	194	11	and	and	CCONJ
bjp-33625	194	12	characterization	characterization	NOUN
bjp-33625	194	13	of	of	ADP
bjp-33625	194	14	benzimidazole	benzimidazole	ADJ
bjp-33625	194	15	derivatives	derivative	NOUN
bjp-33625	194	16	by	by	ADP
bjp-33625	194	17	sonogashira	sonogashira	NOUN
bjp-33625	194	18	coupling	coupling	NOUN
bjp-33625	194	19	and	and	CCONJ
bjp-33625	194	20	evaluation	evaluation	NOUN
bjp-33625	194	21	of	of	ADP
bjp-33625	194	22	anthelmintic	anthelmintic	ADJ
bjp-33625	194	23	activity	activity	NOUN
bjp-33625	194	24	.	.	PUNCT
bjp-33625	195	1	der	der	ADJ
bjp-33625	195	2	pharma	pharma	PROPN
bjp-33625	195	3	chemica	chemica	PROPN
bjp-33625	195	4	.	.	PUNCT
bjp-33625	196	1	2013	2013	NUM
bjp-33625	196	2	;	;	PUNCT
bjp-33625	196	3	5	5	NUM
bjp-33625	196	4	:	:	SYM
bjp-33625	196	5	369	369	NUM
bjp-33625	196	6	-	-	SYM
bjp-33625	196	7	76	76	NUM
bjp-33625	196	8	.	.	PUNCT
bjp-33625	197	1	sharma	sharma	PROPN
bjp-33625	197	2	s	s	PROPN
bjp-33625	197	3	,	,	PUNCT
bjp-33625	197	4	sandeep	sandeep	PROPN
bjp-33625	197	5	k	k	PROPN
bjp-33625	197	6	,	,	PUNCT
bjp-33625	197	7	tania	tania	PROPN
bjp-33625	197	8	b	b	PROPN
bjp-33625	197	9	,	,	PUNCT
bjp-33625	197	10	jyoti	jyoti	PROPN
bjp-33625	197	11	g.	g.	PROPN
bjp-33625	197	12	review	review	PROPN
bjp-33625	197	13	on	on	ADP
bjp-33625	197	14	synthesis	synthesis	NOUN
bjp-33625	197	15	of	of	ADP
bjp-33625	197	16	bioactive	bioactive	ADJ
bjp-33625	197	17	pyrazoline	pyrazoline	NOUN
bjp-33625	197	18	derivatives	derivative	NOUN
bjp-33625	197	19	.	.	PUNCT
bjp-33625	198	1	chem	chem	PROPN
bjp-33625	198	2	sci	sci	PROPN
bjp-33625	198	3	trans	trans	PROPN
bjp-33625	198	4	.	.	PROPN
bjp-33625	198	5	2014	2014	NUM
bjp-33625	198	6	;	;	PUNCT
bjp-33625	198	7	3	3	NUM
bjp-33625	198	8	:	:	SYM
bjp-33625	198	9	861	861	NUM
bjp-33625	198	10	-	-	SYM
bjp-33625	198	11	75	75	NUM
bjp-33625	198	12	.	.	PUNCT
bjp-33625	199	1	vijesh	vijesh	PROPN
bjp-33625	199	2	am	am	PROPN
bjp-33625	199	3	,	,	PUNCT
bjp-33625	199	4	arun	arun	PROPN
bjp-33625	199	5	mi	mi	PROPN
bjp-33625	199	6	,	,	PUNCT
bjp-33625	199	7	sandeep	sandeep	PROPN
bjp-33625	199	8	t	t	PROPN
bjp-33625	199	9	,	,	PUNCT
bjp-33625	199	10	preethambar	preethambar	X
bjp-33625	199	11	sk	sk	PROPN
bjp-33625	199	12	,	,	PUNCT
bjp-33625	199	13	sankappa	sankappa	PROPN
bjp-33625	199	14	r	r	PROPN
bjp-33625	199	15	,	,	PUNCT
bjp-33625	199	16	nishitha	nishitha	ADJ
bjp-33625	199	17	i.	i.	NOUN
bjp-33625	199	18	synthesis	synthesis	NOUN
bjp-33625	199	19	,	,	PUNCT
bjp-33625	199	20	characterization	characterization	NOUN
bjp-33625	199	21	and	and	CCONJ
bjp-33625	199	22	antimicrobial	antimicrobial	ADJ
bjp-33625	199	23	studies	study	NOUN
bjp-33625	199	24	of	of	ADP
bjp-33625	199	25	some	some	DET
bjp-33625	199	26	pyrazole	pyrazole	NOUN
bjp-33625	199	27	incorporated	incorporate	VERB
bjp-33625	199	28	imidazole	imidazole	NOUN
bjp-33625	199	29	derivatives	derivative	NOUN
bjp-33625	199	30	.	.	PUNCT
bjp-33625	200	1	eur	eur	PROPN
bjp-33625	200	2	j	j	PROPN
bjp-33625	200	3	med	med	PROPN
bjp-33625	200	4	chem	chem	NOUN
bjp-33625	200	5	.	.	PUNCT
bjp-33625	201	1	2011	2011	NUM
bjp-33625	201	2	;	;	PUNCT
bjp-33625	201	3	8	8	NUM
bjp-33625	201	4	:	:	PUNCT
bjp-33625	201	5	3531	3531	NUM
bjp-33625	201	6	-	-	SYM
bjp-33625	201	7	36	36	NUM
bjp-33625	201	8	.	.	PUNCT
bjp-33625	202	1	wade	wade	PROPN
bjp-33625	202	2	rc	rc	PROPN
bjp-33625	202	3	,	,	PUNCT
bjp-33625	202	4	goodford	goodford	PROPN
bjp-33625	202	5	pj	pj	PROPN
bjp-33625	202	6	.	.	PUNCT
bjp-33625	203	1	the	the	DET
bjp-33625	203	2	role	role	NOUN
bjp-33625	203	3	of	of	ADP
bjp-33625	203	4	hydrogen	hydrogen	NOUN
bjp-33625	203	5	-	-	PUNCT
bjp-33625	203	6	bonds	bond	NOUN
bjp-33625	203	7	in	in	ADP
bjp-33625	203	8	drug	drug	NOUN
bjp-33625	203	9	binding	bind	VERB
bjp-33625	203	10	.	.	PUNCT
bjp-33625	204	1	prog	prog	PROPN
bjp-33625	204	2	clin	clin	PROPN
bjp-33625	204	3	biol	biol	PROPN
bjp-33625	204	4	res	re	NOUN
bjp-33625	204	5	.	.	PUNCT
bjp-33625	204	6	1989	1989	NUM
bjp-33625	204	7	;	;	PUNCT
bjp-33625	204	8	289	289	NUM
bjp-33625	204	9	:	:	PUNCT
bjp-33625	204	10	433	433	NUM
bjp-33625	204	11	-	-	SYM
bjp-33625	204	12	44	44	NUM
bjp-33625	204	13	.	.	PUNCT
bjp-33625	205	1	yuthavong	yuthavong	PROPN
bjp-33625	205	2	y	y	PROPN
bjp-33625	205	3	,	,	PUNCT
bjp-33625	205	4	tarnchompoo	tarnchompoo	NOUN
bjp-33625	205	5	b	b	NOUN
bjp-33625	205	6	,	,	PUNCT
bjp-33625	205	7	vilaivan	vilaivan	PROPN
bjp-33625	205	8	t	t	PROPN
bjp-33625	205	9	,	,	PUNCT
bjp-33625	205	10	chitnumsub	chitnumsub	VERB
bjp-33625	205	11	p	p	NOUN
bjp-33625	205	12	,	,	PUNCT
bjp-33625	205	13	kamchonwongpaisan	kamchonwongpaisan	PROPN
bjp-33625	205	14	s	s	PROPN
bjp-33625	205	15	,	,	PUNCT
bjp-33625	205	16	charman	charman	PROPN
bjp-33625	205	17	sa	sa	PROPN
bjp-33625	205	18	,	,	PUNCT
bjp-33625	205	19	mclennan	mclennan	PROPN
bjp-33625	205	20	dn	dn	PROPN
bjp-33625	205	21	,	,	PUNCT
bjp-33625	205	22	white	white	PROPN
bjp-33625	205	23	kl	kl	PROPN
bjp-33625	205	24	,	,	PUNCT
bjp-33625	205	25	vivas	vivas	PROPN
bjp-33625	205	26	l	l	PROPN
bjp-33625	205	27	,	,	PUNCT
bjp-33625	205	28	bongard	bongard	NOUN
bjp-33625	205	29	e	e	NOUN
bjp-33625	205	30	,	,	PUNCT
bjp-33625	205	31	thongphanchang	thongphanchang	PROPN
bjp-33625	205	32	c	c	PROPN
bjp-33625	205	33	,	,	PUNCT
bjp-33625	205	34	taweechai	taweechai	PROPN
bjp-33625	205	35	s	s	PROPN
bjp-33625	205	36	,	,	PUNCT
bjp-33625	205	37	vanichtanankul	vanichtanankul	PROPN
bjp-33625	205	38	j	j	PROPN
bjp-33625	205	39	,	,	PUNCT
bjp-33625	205	40	rattanajak	rattanajak	ADV
bjp-33625	205	41	r	r	NOUN
bjp-33625	205	42	,	,	PUNCT
bjp-33625	205	43	arwon	arwon	VERB
bjp-33625	205	44	u	u	NOUN
bjp-33625	205	45	,	,	PUNCT
bjp-33625	205	46	fantauzzi	fantauzzi	NOUN
bjp-33625	205	47	p	p	NOUN
bjp-33625	205	48	,	,	PUNCT
bjp-33625	205	49	yuvaniyama	yuvaniyama	PROPN
bjp-33625	205	50	j	j	PROPN
bjp-33625	205	51	,	,	PUNCT
bjp-33625	205	52	charman	charman	PROPN
bjp-33625	205	53	wn	wn	PROPN
bjp-33625	205	54	,	,	PUNCT
bjp-33625	205	55	matthews	matthews	PROPN
bjp-33625	205	56	d.	d.	PROPN
bjp-33625	205	57	malarial	malarial	PROPN
bjp-33625	205	58	dihydrofolate	dihydrofolate	PROPN
bjp-33625	205	59	reductase	reductase	NOUN
bjp-33625	205	60	as	as	ADP
bjp-33625	205	61	a	a	DET
bjp-33625	205	62	paradigm	paradigm	NOUN
bjp-33625	205	63	for	for	ADP
bjp-33625	205	64	drug	drug	NOUN
bjp-33625	205	65	development	development	NOUN
bjp-33625	205	66	against	against	ADP
bjp-33625	205	67	a	a	DET
bjp-33625	205	68	resistance	resistance	NOUN
bjp-33625	205	69	-	-	PUNCT
bjp-33625	205	70	compromised	compromise	VERB
bjp-33625	205	71	target	target	NOUN
bjp-33625	205	72	.	.	PUNCT
bjp-33625	206	1	proc	proc	PROPN
bjp-33625	206	2	natl	natl	PROPN
bjp-33625	206	3	acad	acad	PROPN
bjp-33625	206	4	sci	sci	PROPN
bjp-33625	206	5	.	.	PROPN
bjp-33625	206	6	2012	2012	NUM
bjp-33625	206	7	;	;	PUNCT
bjp-33625	206	8	109	109	NUM
bjp-33625	206	9	:	:	SYM
bjp-33625	206	10	16823	16823	NUM
bjp-33625	206	11	-	-	SYM
bjp-33625	206	12	28	28	NUM
bjp-33625	206	13	.	.	PUNCT
bjp-33625	207	1	bangladesh	bangladesh	PROPN
bjp-33625	207	2	j	j	PROPN
bjp-33625	207	3	pharmacol	pharmacol	PROPN
bjp-33625	207	4	2018	2018	NUM
bjp-33625	207	5	;	;	PUNCT
bjp-33625	207	6	13	13	NUM
bjp-33625	207	7	:	:	SYM
bjp-33625	207	8	23	23	NUM
bjp-33625	207	9	-	-	SYM
bjp-33625	207	10	29	29	NUM
bjp-33625	207	11	29	29	NUM
bjp-33625	207	12	conclusion	conclusion	NOUN
bjp-33625	207	13	:	:	PUNCT
bjp-33625	207	14	acknowledgement	acknowledgement	NOUN
bjp-33625	207	15	:	:	PUNCT
bjp-33625	207	16	dateprinted	dateprinte	VERB
bjp-33625	207	17	:	:	PUNCT
bjp-33625	207	18	this	this	DET
bjp-33625	207	19	article	article	NOUN
bjp-33625	207	20	was	be	AUX
bjp-33625	207	21	downloaded	download	VERB
bjp-33625	207	22	by	by	ADP
bjp-33625	207	23	you	you	PRON
bjp-33625	207	24	on	on	ADP
bjp-33625	207	25	:	:	PUNCT
bjp-33625	207	26	jan	jan	PROPN
bjp-33625	207	27	14	14	NUM
bjp-33625	207	28	,	,	PUNCT
bjp-33625	207	29	2019	2019	NUM