id	sid	tid	token	lemma	pos
bjp-59809	1	1	bangladesh	bangladesh	PROPN
bjp-59809	1	2	journal	journal	PROPN
bjp-59809	1	3	of	of	ADP
bjp-59809	1	4	pharmacology	pharmacology	NOUN
bjp-59809	1	5	research	research	NOUN
bjp-59809	1	6	article	article	NOUN
bjp-59809	1	7	inhibitory	inhibitory	ADJ
bjp-59809	1	8	effect	effect	NOUN
bjp-59809	1	9	of	of	ADP
bjp-59809	1	10	ak-7	ak-7	X
bjp-59809	1	11	mediates	mediate	NOUN
bjp-59809	1	12	by	by	ADP
bjp-59809	1	13	apoptosis	apoptosis	NOUN
bjp-59809	1	14	,	,	PUNCT
bjp-59809	1	15	increases	increase	VERB
bjp-59809	1	16	dna	dna	PROPN
bjp-59809	1	17	fragmentation	fragmentation	NOUN
bjp-59809	1	18	and	and	CCONJ
bjp-59809	1	19	caspase-3	caspase-3	NUM
bjp-59809	1	20	activity	activity	NOUN
bjp-59809	1	21	in	in	ADP
bjp-59809	1	22	human	human	ADJ
bjp-59809	1	23	glioblastoma	glioblastoma	NOUN
bjp-59809	1	24	multiforme	multiforme	NOUN
bjp-59809	1	25	cells	cell	NOUN
bjp-59809	1	26	bjp	bjp	PROPN
bjp-59809	1	27	introduction	introduction	NOUN
bjp-59809	1	28	glioblastoma	glioblastoma	NOUN
bjp-59809	1	29	multiforme	multiforme	NOUN
bjp-59809	1	30	is	be	AUX
bjp-59809	1	31	the	the	DET
bjp-59809	1	32	most	most	ADV
bjp-59809	1	33	common	common	ADJ
bjp-59809	1	34	primary	primary	ADJ
bjp-59809	1	35	brain	brain	NOUN
bjp-59809	1	36	tumor	tumor	NOUN
bjp-59809	1	37	,	,	PUNCT
bjp-59809	1	38	accounting	account	VERB
bjp-59809	1	39	for	for	ADP
bjp-59809	1	40	approximately	approximately	ADV
bjp-59809	1	41	60	60	NUM
bjp-59809	1	42	%	%	NOUN
bjp-59809	1	43	of	of	ADP
bjp-59809	1	44	all	all	DET
bjp-59809	1	45	brain	brain	NOUN
bjp-59809	1	46	tumors	tumor	NOUN
bjp-59809	1	47	.	.	PUNCT
bjp-59809	2	1	the	the	DET
bjp-59809	2	2	5	5	NUM
bjp-59809	2	3	-	-	PUNCT
bjp-59809	2	4	year	year	NOUN
bjp-59809	2	5	survival	survival	NOUN
bjp-59809	2	6	rate	rate	NOUN
bjp-59809	2	7	is	be	AUX
bjp-59809	2	8	approximately	approximately	ADV
bjp-59809	2	9	5	5	NUM
bjp-59809	2	10	-	-	SYM
bjp-59809	2	11	10	10	NUM
bjp-59809	2	12	%	%	NOUN
bjp-59809	2	13	and	and	CCONJ
bjp-59809	2	14	the	the	DET
bjp-59809	2	15	median	median	ADJ
bjp-59809	2	16	survival	survival	NOUN
bjp-59809	2	17	is	be	AUX
bjp-59809	2	18	10	10	NUM
bjp-59809	2	19	months	month	NOUN
bjp-59809	2	20	(	(	PUNCT
bjp-59809	2	21	taylor	taylor	PROPN
bjp-59809	2	22	et	et	PROPN
bjp-59809	2	23	al	al	PROPN
bjp-59809	2	24	.	.	PROPN
bjp-59809	2	25	,	,	PUNCT
bjp-59809	2	26	2019	2019	NUM
bjp-59809	2	27	)	)	PUNCT
bjp-59809	2	28	.	.	PUNCT
bjp-59809	3	1	treatment	treatment	NOUN
bjp-59809	3	2	of	of	ADP
bjp-59809	3	3	glioblastoma	glioblastoma	NOUN
bjp-59809	3	4	multiforme	multiforme	NOUN
bjp-59809	3	5	includes	include	VERB
bjp-59809	3	6	radiotherapy	radiotherapy	NOUN
bjp-59809	3	7	and	and	CCONJ
bjp-59809	3	8	the	the	DET
bjp-59809	3	9	use	use	NOUN
bjp-59809	3	10	of	of	ADP
bjp-59809	3	11	temozolomide	temozolomide	NOUN
bjp-59809	3	12	after	after	ADP
bjp-59809	3	13	surgical	surgical	ADJ
bjp-59809	3	14	resection	resection	NOUN
bjp-59809	3	15	(	(	PUNCT
bjp-59809	3	16	salami	salami	NOUN
bjp-59809	3	17	et	et	PROPN
bjp-59809	3	18	al	al	PROPN
bjp-59809	3	19	.	.	PROPN
bjp-59809	3	20	,	,	PUNCT
bjp-59809	3	21	2022	2022	NUM
bjp-59809	3	22	)	)	PUNCT
bjp-59809	3	23	.	.	PUNCT
bjp-59809	4	1	it	it	PRON
bjp-59809	4	2	is	be	AUX
bjp-59809	4	3	a	a	DET
bjp-59809	4	4	highly	highly	ADV
bjp-59809	4	5	aggressive	aggressive	ADJ
bjp-59809	4	6	cancer	cancer	NOUN
bjp-59809	4	7	with	with	ADP
bjp-59809	4	8	a	a	DET
bjp-59809	4	9	high	high	ADJ
bjp-59809	4	10	invasive	invasive	ADJ
bjp-59809	4	11	ability	ability	NOUN
bjp-59809	4	12	.	.	PUNCT
bjp-59809	5	1	for	for	ADP
bjp-59809	5	2	this	this	DET
bjp-59809	5	3	reason	reason	NOUN
bjp-59809	5	4	,	,	PUNCT
bjp-59809	5	5	resistance	resistance	NOUN
bjp-59809	5	6	to	to	ADP
bjp-59809	5	7	treatment	treatment	NOUN
bjp-59809	5	8	may	may	AUX
bjp-59809	5	9	develop	develop	VERB
bjp-59809	5	10	or	or	CCONJ
bjp-59809	5	11	treatment	treatment	NOUN
bjp-59809	5	12	can	can	AUX
bjp-59809	5	13	not	not	PART
bjp-59809	5	14	be	be	AUX
bjp-59809	5	15	successful	successful	ADJ
bjp-59809	5	16	(	(	PUNCT
bjp-59809	5	17	ghani	ghani	PROPN
bjp-59809	5	18	et	et	PROPN
bjp-59809	5	19	al	al	PROPN
bjp-59809	5	20	.	.	PROPN
bjp-59809	5	21	,	,	PUNCT
bjp-59809	5	22	2022	2022	NUM
bjp-59809	5	23	)	)	PUNCT
bjp-59809	5	24	.	.	PUNCT
bjp-59809	6	1	therefore	therefore	ADV
bjp-59809	6	2	,	,	PUNCT
bjp-59809	6	3	the	the	DET
bjp-59809	6	4	identification	identification	NOUN
bjp-59809	6	5	of	of	ADP
bjp-59809	6	6	new	new	ADJ
bjp-59809	6	7	molecular	molecular	ADJ
bjp-59809	6	8	targets	target	NOUN
bjp-59809	6	9	that	that	PRON
bjp-59809	6	10	can	can	AUX
bjp-59809	6	11	be	be	AUX
bjp-59809	6	12	effective	effective	ADJ
bjp-59809	6	13	in	in	ADP
bjp-59809	6	14	glioblastoma	glioblastoma	NOUN
bjp-59809	6	15	multiforme	multiforme	NOUN
bjp-59809	6	16	will	will	AUX
bjp-59809	6	17	contribute	contribute	VERB
bjp-59809	6	18	to	to	ADP
bjp-59809	6	19	the	the	DET
bjp-59809	6	20	development	development	NOUN
bjp-59809	6	21	of	of	ADP
bjp-59809	6	22	new	new	ADJ
bjp-59809	6	23	therapeutic	therapeutic	ADJ
bjp-59809	6	24	strategies	strategy	NOUN
bjp-59809	6	25	.	.	PUNCT
bjp-59809	7	1	sirtuins	sirtuin	NOUN
bjp-59809	7	2	(	(	PUNCT
bjp-59809	7	3	sirts	sirts	PROPN
bjp-59809	7	4	)	)	PUNCT
bjp-59809	7	5	,	,	PUNCT
bjp-59809	7	6	are	be	AUX
bjp-59809	7	7	nicotinamide	nicotinamide	NOUN
bjp-59809	7	8	adenine	adenine	ADJ
bjp-59809	7	9	dinucleotide	dinucleotide	NOUN
bjp-59809	7	10	(	(	PUNCT
bjp-59809	7	11	nad+	nad+	NOUN
bjp-59809	7	12	)	)	PUNCT
bjp-59809	7	13	dependent	dependent	ADJ
bjp-59809	7	14	class	class	NOUN
bjp-59809	7	15	iii	iii	NUM
bjp-59809	7	16	histondeacetylases	histondeacetylase	NOUN
bjp-59809	7	17	and	and	CCONJ
bjp-59809	7	18	regulate	regulate	VERB
bjp-59809	7	19	cellular	cellular	ADJ
bjp-59809	7	20	functions	function	NOUN
bjp-59809	7	21	through	through	ADP
bjp-59809	7	22	deacetylation	deacetylation	NOUN
bjp-59809	7	23	of	of	ADP
bjp-59809	7	24	proteins	protein	NOUN
bjp-59809	7	25	(	(	PUNCT
bjp-59809	7	26	zhang	zhang	X
bjp-59809	7	27	et	et	PROPN
bjp-59809	7	28	al	al	PROPN
bjp-59809	7	29	.	.	PROPN
bjp-59809	7	30	,	,	PUNCT
bjp-59809	7	31	2020	2020	NUM
bjp-59809	7	32	)	)	PUNCT
bjp-59809	7	33	.	.	PUNCT
bjp-59809	8	1	sirt2	sirt2	PROPN
bjp-59809	8	2	was	be	AUX
bjp-59809	8	3	the	the	DET
bjp-59809	8	4	first	first	ADJ
bjp-59809	8	5	sirt	sirt	PROPN
bjp-59809	8	6	identified	identify	VERB
bjp-59809	8	7	in	in	ADP
bjp-59809	8	8	saccharomyces	saccharomyce	NOUN
bjp-59809	8	9	cerevisiae	cerevisiae	NOUN
bjp-59809	8	10	.	.	PUNCT
bjp-59809	9	1	in	in	ADP
bjp-59809	9	2	mammals	mammal	NOUN
bjp-59809	9	3	,	,	PUNCT
bjp-59809	9	4	there	there	PRON
bjp-59809	9	5	are	be	VERB
bjp-59809	9	6	7	7	NUM
bjp-59809	9	7	homologs	homolog	NOUN
bjp-59809	9	8	(	(	PUNCT
bjp-59809	9	9	sirt1	sirt1	NOUN
bjp-59809	9	10	-	-	PUNCT
bjp-59809	9	11	sirt7	sirt7	NOUN
bjp-59809	9	12	)	)	PUNCT
bjp-59809	9	13	of	of	ADP
bjp-59809	9	14	sirt2	sirt2	NOUN
bjp-59809	9	15	which	which	PRON
bjp-59809	9	16	have	have	VERB
bjp-59809	9	17	a	a	DET
bjp-59809	9	18	highly	highly	ADV
bjp-59809	9	19	conserved	conserved	ADJ
bjp-59809	9	20	central	central	ADJ
bjp-59809	9	21	nad1	nad1	NOUN
bjp-59809	9	22	binding	bind	VERB
bjp-59809	9	23	and	and	CCONJ
bjp-59809	9	24	a	a	DET
bjp-59809	9	25	common	common	ADJ
bjp-59809	9	26	catalytic	catalytic	ADJ
bjp-59809	9	27	domain	domain	NOUN
bjp-59809	9	28	(	(	PUNCT
bjp-59809	9	29	singh	singh	PROPN
bjp-59809	9	30	et	et	PROPN
bjp-59809	9	31	al	al	PROPN
bjp-59809	9	32	.	.	PROPN
bjp-59809	9	33	,	,	PUNCT
bjp-59809	9	34	2018	2018	NUM
bjp-59809	9	35	)	)	PUNCT
bjp-59809	9	36	.	.	PUNCT
bjp-59809	10	1	of	of	ADP
bjp-59809	10	2	these	these	PRON
bjp-59809	10	3	,	,	PUNCT
bjp-59809	10	4	sirt1	sirt1	NOUN
bjp-59809	10	5	and	and	CCONJ
bjp-59809	10	6	sirt2	sirt2	PROPN
bjp-59809	10	7	are	be	AUX
bjp-59809	10	8	localized	localize	VERB
bjp-59809	10	9	in	in	ADP
bjp-59809	10	10	the	the	DET
bjp-59809	10	11	nucleus	nucleus	NOUN
bjp-59809	10	12	and	and	CCONJ
bjp-59809	10	13	cytoplasm	cytoplasm	NOUN
bjp-59809	10	14	,	,	PUNCT
bjp-59809	10	15	sirt1	sirt1	NOUN
bjp-59809	10	16	is	be	AUX
bjp-59809	10	17	predominantly	predominantly	ADV
bjp-59809	10	18	in	in	ADP
bjp-59809	10	19	nucleus	nucleus	NOUN
bjp-59809	10	20	and	and	CCONJ
bjp-59809	10	21	sirt2	sirt2	PROPN
bjp-59809	10	22	is	be	AUX
bjp-59809	10	23	predominantly	predominantly	ADV
bjp-59809	10	24	in	in	ADP
bjp-59809	10	25	the	the	DET
bjp-59809	10	26	cytoplasm	cytoplasm	NOUN
bjp-59809	10	27	.	.	PUNCT
bjp-59809	11	1	sirt3	sirt3	PROPN
bjp-59809	11	2	,	,	PUNCT
bjp-59809	11	3	sirt4	sirt4	NOUN
bjp-59809	11	4	,	,	PUNCT
bjp-59809	11	5	and	and	CCONJ
bjp-59809	11	6	sirt5	sirt5	NOUN
bjp-59809	11	7	are	be	AUX
bjp-59809	11	8	mitochondrial	mitochondrial	ADJ
bjp-59809	11	9	sirts	sirt	NOUN
bjp-59809	11	10	.	.	PUNCT
bjp-59809	12	1	sirt6	sirt6	NOUN
bjp-59809	12	2	is	be	AUX
bjp-59809	12	3	found	find	VERB
bjp-59809	12	4	in	in	ADP
bjp-59809	12	5	the	the	DET
bjp-59809	12	6	nucleus	nucleus	NOUN
bjp-59809	12	7	while	while	SCONJ
bjp-59809	12	8	sirt7	sirt7	PROPN
bjp-59809	12	9	is	be	AUX
bjp-59809	12	10	found	find	VERB
bjp-59809	12	11	in	in	ADP
bjp-59809	12	12	the	the	DET
bjp-59809	12	13	nucleolus	nucleolus	NOUN
bjp-59809	12	14	.	.	PUNCT
bjp-59809	13	1	the	the	DET
bjp-59809	13	2	different	different	ADJ
bjp-59809	13	3	cellular	cellular	ADJ
bjp-59809	13	4	localization	localization	NOUN
bjp-59809	13	5	of	of	ADP
bjp-59809	13	6	sirts	sirt	NOUN
bjp-59809	13	7	are	be	AUX
bjp-59809	13	8	indicative	indicative	ADJ
bjp-59809	13	9	of	of	ADP
bjp-59809	13	10	their	their	PRON
bjp-59809	13	11	wide	wide	ADJ
bjp-59809	13	12	range	range	NOUN
bjp-59809	13	13	of	of	ADP
bjp-59809	13	14	biological	biological	ADJ
bjp-59809	13	15	roles	role	NOUN
bjp-59809	13	16	such	such	ADJ
bjp-59809	13	17	as	as	ADP
bjp-59809	13	18	regulation	regulation	NOUN
bjp-59809	13	19	of	of	ADP
bjp-59809	13	20	cell	cell	NOUN
bjp-59809	13	21	cycle	cycle	NOUN
bjp-59809	13	22	,	,	PUNCT
bjp-59809	13	23	cell	cell	NOUN
bjp-59809	13	24	survival	survival	NOUN
bjp-59809	13	25	,	,	PUNCT
bjp-59809	13	26	apoptosis	apoptosis	NOUN
bjp-59809	13	27	,	,	PUNCT
bjp-59809	13	28	lipid	lipid	NOUN
bjp-59809	13	29	and	and	CCONJ
bjp-59809	13	30	glucose	glucose	NOUN
bjp-59809	13	31	homeostasis	homeostasis	NOUN
bjp-59809	13	32	,	,	PUNCT
bjp-59809	13	33	metabolism	metabolism	NOUN
bjp-59809	13	34	,	,	PUNCT
bjp-59809	13	35	inflammation	inflammation	NOUN
bjp-59809	13	36	,	,	PUNCT
bjp-59809	13	37	dna	dna	PROPN
bjp-59809	13	38	repair	repair	NOUN
bjp-59809	13	39	,	,	PUNCT
bjp-59809	13	40	genome	genome	NOUN
bjp-59809	13	41	stability	stability	NOUN
bjp-59809	13	42	,	,	PUNCT
bjp-59809	13	43	and	and	CCONJ
bjp-59809	13	44	mitochondrial	mitochondrial	ADJ
bjp-59809	13	45	functions	function	NOUN
bjp-59809	13	46	(	(	PUNCT
bjp-59809	13	47	yamamoto	yamamoto	NOUN
bjp-59809	13	48	et	et	PROPN
bjp-59809	13	49	al	al	PROPN
bjp-59809	13	50	.	.	PROPN
bjp-59809	13	51	,	,	PUNCT
bjp-59809	13	52	2007	2007	NUM
bjp-59809	13	53	;	;	PUNCT
bjp-59809	13	54	shoba	shoba	VERB
bjp-59809	13	55	et	et	PROPN
bjp-59809	13	56	al	al	PROPN
bjp-59809	13	57	.	.	PROPN
bjp-59809	13	58	,	,	PUNCT
bjp-59809	13	59	2009	2009	NUM
bjp-59809	13	60	;	;	PUNCT
bjp-59809	13	61	villalba	villalba	NOUN
bjp-59809	13	62	and	and	CCONJ
bjp-59809	13	63	alcaín	alcaín	NOUN
bjp-59809	13	64	,	,	PUNCT
bjp-59809	13	65	2012	2012	NUM
bjp-59809	13	66	;	;	PUNCT
bjp-59809	13	67	abstract	abstract	ADJ
bjp-59809	13	68	sirtuins	sirtuin	NOUN
bjp-59809	13	69	(	(	PUNCT
bjp-59809	13	70	sirts	sirt	NOUN
bjp-59809	13	71	)	)	PUNCT
bjp-59809	13	72	which	which	PRON
bjp-59809	13	73	are	be	AUX
bjp-59809	13	74	nicotinamide	nicotinamide	NOUN
bjp-59809	13	75	adenine	adenine	ADJ
bjp-59809	13	76	dinucleotide	dinucleotide	NOUN
bjp-59809	13	77	(	(	PUNCT
bjp-59809	13	78	nad+	nad+	NOUN
bjp-59809	13	79	)	)	PUNCT
bjp-59809	13	80	dependent	dependent	ADJ
bjp-59809	13	81	class	class	NOUN
bjp-59809	13	82	iii	iii	NUM
bjp-59809	13	83	histondeacetylases	histondeacetylase	NOUN
bjp-59809	13	84	have	have	VERB
bjp-59809	13	85	a	a	DET
bjp-59809	13	86	controversial	controversial	ADJ
bjp-59809	13	87	role	role	NOUN
bjp-59809	13	88	in	in	ADP
bjp-59809	13	89	cancer	cancer	NOUN
bjp-59809	13	90	.	.	PUNCT
bjp-59809	14	1	in	in	ADP
bjp-59809	14	2	this	this	DET
bjp-59809	14	3	study	study	NOUN
bjp-59809	14	4	,	,	PUNCT
bjp-59809	14	5	the	the	DET
bjp-59809	14	6	effect	effect	NOUN
bjp-59809	14	7	of	of	ADP
bjp-59809	14	8	pharmacological	pharmacological	ADJ
bjp-59809	14	9	inhibition	inhibition	NOUN
bjp-59809	14	10	of	of	ADP
bjp-59809	14	11	ak-7	ak-7	ADP
bjp-59809	14	12	,	,	PUNCT
bjp-59809	14	13	a	a	DET
bjp-59809	14	14	sirt2	sirt2	NOUN
bjp-59809	14	15	inhibitor	inhibitor	NOUN
bjp-59809	14	16	,	,	PUNCT
bjp-59809	14	17	was	be	AUX
bjp-59809	14	18	investigated	investigate	VERB
bjp-59809	14	19	in	in	ADP
bjp-59809	14	20	u87	u87	ADJ
bjp-59809	14	21	glioblastoma	glioblastoma	NOUN
bjp-59809	14	22	multiforme	multiforme	NOUN
bjp-59809	14	23	cells	cell	NOUN
bjp-59809	14	24	.	.	PUNCT
bjp-59809	15	1	the	the	DET
bjp-59809	15	2	cytotoxic	cytotoxic	ADJ
bjp-59809	15	3	effect	effect	NOUN
bjp-59809	15	4	of	of	ADP
bjp-59809	15	5	ak-7	ak-7	ADV
bjp-59809	15	6	was	be	AUX
bjp-59809	15	7	evaluated	evaluate	VERB
bjp-59809	15	8	by	by	ADP
bjp-59809	15	9	xtt	xtt	PROPN
bjp-59809	15	10	analysis	analysis	NOUN
bjp-59809	15	11	.	.	PUNCT
bjp-59809	16	1	after	after	ADP
bjp-59809	16	2	ak-7	ak-7	ADP
bjp-59809	16	3	treatment	treatment	NOUN
bjp-59809	16	4	,	,	PUNCT
bjp-59809	16	5	colony	colony	NOUN
bjp-59809	16	6	forming	form	VERB
bjp-59809	16	7	capacity	capacity	NOUN
bjp-59809	16	8	of	of	ADP
bjp-59809	16	9	cells	cell	NOUN
bjp-59809	16	10	was	be	AUX
bjp-59809	16	11	determined	determine	VERB
bjp-59809	16	12	and	and	CCONJ
bjp-59809	16	13	apoptosis	apoptosis	NOUN
bjp-59809	16	14	was	be	AUX
bjp-59809	16	15	evaluated	evaluate	VERB
bjp-59809	16	16	.	.	PUNCT
bjp-59809	17	1	the	the	DET
bjp-59809	17	2	expression	expression	NOUN
bjp-59809	17	3	levels	level	NOUN
bjp-59809	17	4	of	of	ADP
bjp-59809	17	5	apoptosis	apoptosis	NOUN
bjp-59809	17	6	-	-	PUNCT
bjp-59809	17	7	related	relate	VERB
bjp-59809	17	8	genes	gene	NOUN
bjp-59809	17	9	were	be	AUX
bjp-59809	17	10	determined	determine	VERB
bjp-59809	17	11	by	by	ADP
bjp-59809	17	12	qrt	qrt	NOUN
bjp-59809	17	13	-	-	PUNCT
bjp-59809	17	14	pcr	pcr	NOUN
bjp-59809	17	15	.	.	PUNCT
bjp-59809	18	1	according	accord	VERB
bjp-59809	18	2	to	to	ADP
bjp-59809	18	3	the	the	DET
bjp-59809	18	4	results	result	NOUN
bjp-59809	18	5	,	,	PUNCT
bjp-59809	18	6	ak-7	ak-7	CCONJ
bjp-59809	18	7	inhibited	inhibited	ADJ
bjp-59809	18	8	cell	cell	NOUN
bjp-59809	18	9	proliferation	proliferation	NOUN
bjp-59809	18	10	in	in	ADP
bjp-59809	18	11	a	a	DET
bjp-59809	18	12	doseand	doseand	ADJ
bjp-59809	18	13	time	time	NOUN
bjp-59809	18	14	-	-	PUNCT
bjp-59809	18	15	dependent	dependent	ADJ
bjp-59809	18	16	manner	manner	NOUN
bjp-59809	18	17	.	.	PUNCT
bjp-59809	19	1	after	after	ADP
bjp-59809	19	2	ak-7	ak-7	ADP
bjp-59809	19	3	treatment	treatment	NOUN
bjp-59809	19	4	,	,	PUNCT
bjp-59809	19	5	the	the	DET
bjp-59809	19	6	colony	colony	NOUN
bjp-59809	19	7	forming	form	VERB
bjp-59809	19	8	capacity	capacity	NOUN
bjp-59809	19	9	of	of	ADP
bjp-59809	19	10	u87	u87	ADJ
bjp-59809	19	11	cells	cell	NOUN
bjp-59809	19	12	was	be	AUX
bjp-59809	19	13	suppressed	suppress	VERB
bjp-59809	19	14	.	.	PUNCT
bjp-59809	20	1	and	and	CCONJ
bjp-59809	20	2	,	,	PUNCT
bjp-59809	20	3	ak-7	ak-7	CCONJ
bjp-59809	20	4	increased	increase	VERB
bjp-59809	20	5	apoptosis	apoptosis	NOUN
bjp-59809	20	6	rate	rate	NOUN
bjp-59809	20	7	,	,	PUNCT
bjp-59809	20	8	dna	dna	PROPN
bjp-59809	20	9	fragmentation	fragmentation	NOUN
bjp-59809	20	10	,	,	PUNCT
bjp-59809	20	11	and	and	CCONJ
bjp-59809	20	12	caspase-3	caspase-3	NUM
bjp-59809	20	13	activity	activity	NOUN
bjp-59809	20	14	.	.	PUNCT
bjp-59809	21	1	according	accord	VERB
bjp-59809	21	2	to	to	ADP
bjp-59809	21	3	qrt	qrt	NOUN
bjp-59809	21	4	-	-	PUNCT
bjp-59809	21	5	pcr	pcr	ADJ
bjp-59809	21	6	,	,	PUNCT
bjp-59809	21	7	a	a	DET
bjp-59809	21	8	significant	significant	ADJ
bjp-59809	21	9	increase	increase	NOUN
bjp-59809	21	10	was	be	AUX
bjp-59809	21	11	observed	observe	VERB
bjp-59809	21	12	in	in	ADP
bjp-59809	21	13	expression	expression	NOUN
bjp-59809	21	14	levels	level	NOUN
bjp-59809	21	15	of	of	ADP
bjp-59809	21	16	apoptosis	apoptosis	NOUN
bjp-59809	21	17	-	-	PUNCT
bjp-59809	21	18	related	relate	VERB
bjp-59809	21	19	genes	gene	NOUN
bjp-59809	21	20	.	.	PUNCT
bjp-59809	22	1	this	this	DET
bjp-59809	22	2	study	study	NOUN
bjp-59809	22	3	revealed	reveal	VERB
bjp-59809	22	4	that	that	SCONJ
bjp-59809	22	5	ak-7	ak-7	CCONJ
bjp-59809	22	6	inhibits	inhibit	VERB
bjp-59809	22	7	cell	cell	NOUN
bjp-59809	22	8	proliferation	proliferation	NOUN
bjp-59809	22	9	and	and	CCONJ
bjp-59809	22	10	induces	induce	VERB
bjp-59809	22	11	apoptosis	apoptosis	NOUN
bjp-59809	22	12	in	in	ADP
bjp-59809	22	13	glioblastoma	glioblastoma	NOUN
bjp-59809	22	14	multiforme	multiforme	NOUN
bjp-59809	22	15	cells	cell	NOUN
bjp-59809	22	16	and	and	CCONJ
bjp-59809	22	17	sirt2	sirt2	PROPN
bjp-59809	22	18	inhibition	inhibition	NOUN
bjp-59809	22	19	can	can	AUX
bjp-59809	22	20	be	be	AUX
bjp-59809	22	21	evaluated	evaluate	VERB
bjp-59809	22	22	as	as	ADP
bjp-59809	22	23	a	a	DET
bjp-59809	22	24	therapeutic	therapeutic	ADJ
bjp-59809	22	25	approach	approach	NOUN
bjp-59809	22	26	in	in	ADP
bjp-59809	22	27	glioblastoma	glioblastoma	NOUN
bjp-59809	22	28	multiforme	multiforme	NOUN
bjp-59809	22	29	.	.	PUNCT
bjp-59809	23	1	article	article	NOUN
bjp-59809	23	2	info	info	NOUN
bjp-59809	23	3	received	receive	VERB
bjp-59809	23	4	:	:	PUNCT
bjp-59809	23	5	22	22	NUM
bjp-59809	23	6	may	may	AUX
bjp-59809	23	7	2022	2022	NUM
bjp-59809	23	8	accepted	accept	VERB
bjp-59809	23	9	:	:	PUNCT
bjp-59809	23	10	5	5	NUM
bjp-59809	23	11	june	june	PROPN
bjp-59809	23	12	2022	2022	NUM
bjp-59809	23	13	available	available	ADJ
bjp-59809	23	14	online	online	ADV
bjp-59809	23	15	:	:	PUNCT
bjp-59809	23	16	6	6	NUM
bjp-59809	23	17	june	june	PROPN
bjp-59809	23	18	2022	2022	NUM
bjp-59809	23	19	doi	doi	NOUN
bjp-59809	23	20	:	:	PUNCT
bjp-59809	23	21	10.3329	10.3329	NUM
bjp-59809	23	22	/	/	SYM
bjp-59809	23	23	bjp.v17i2.59809	bjp.v17i2.59809	PROPN
bjp-59809	23	24	cite	cite	VERB
bjp-59809	23	25	this	this	DET
bjp-59809	23	26	article	article	NOUN
bjp-59809	23	27	:	:	PUNCT
bjp-59809	23	28	güçlü	güçlü	PROPN
bjp-59809	23	29	e	e	PROPN
bjp-59809	23	30	,	,	PUNCT
bjp-59809	23	31	ayan	ayan	PROPN
bjp-59809	23	32	ic	ic	PROPN
bjp-59809	23	33	,	,	PUNCT
bjp-59809	23	34	vural	vural	PROPN
bjp-59809	23	35	h.	h.	PROPN
bjp-59809	23	36	inhibitory	inhibitory	ADJ
bjp-59809	23	37	effect	effect	NOUN
bjp-59809	23	38	of	of	ADP
bjp-59809	23	39	ak-7	ak-7	X
bjp-59809	23	40	mediates	mediate	NOUN
bjp-59809	23	41	by	by	ADP
bjp-59809	23	42	apoptosis	apoptosis	NOUN
bjp-59809	23	43	,	,	PUNCT
bjp-59809	23	44	increases	increase	VERB
bjp-59809	23	45	dna	dna	PROPN
bjp-59809	23	46	fragmentation	fragmentation	NOUN
bjp-59809	23	47	and	and	CCONJ
bjp-59809	23	48	caspase-3	caspase-3	NUM
bjp-59809	23	49	activity	activity	NOUN
bjp-59809	23	50	in	in	ADP
bjp-59809	23	51	human	human	ADJ
bjp-59809	23	52	glioblastoma	glioblastoma	NOUN
bjp-59809	23	53	multiforme	multiforme	NOUN
bjp-59809	23	54	cells	cell	NOUN
bjp-59809	23	55	.	.	PUNCT
bjp-59809	24	1	bangladesh	bangladesh	PROPN
bjp-59809	24	2	j	j	PROPN
bjp-59809	24	3	pharmacol	pharmacol	PROPN
bjp-59809	24	4	.	.	PUNCT
bjp-59809	24	5	2022	2022	NUM
bjp-59809	24	6	;	;	PUNCT
bjp-59809	24	7	17	17	NUM
bjp-59809	24	8	:	:	SYM
bjp-59809	24	9	42	42	NUM
bjp-59809	24	10	-	-	SYM
bjp-59809	24	11	50	50	NUM
bjp-59809	24	12	.	.	PUNCT
bjp-59809	24	13	inhibitory	inhibitory	ADJ
bjp-59809	24	14	effect	effect	NOUN
bjp-59809	24	15	of	of	ADP
bjp-59809	24	16	ak-7	ak-7	X
bjp-59809	24	17	mediates	mediate	NOUN
bjp-59809	24	18	by	by	ADP
bjp-59809	24	19	apoptosis	apoptosis	NOUN
bjp-59809	24	20	,	,	PUNCT
bjp-59809	24	21	increases	increase	VERB
bjp-59809	24	22	dna	dna	PROPN
bjp-59809	24	23	fragmentation	fragmentation	NOUN
bjp-59809	24	24	and	and	CCONJ
bjp-59809	24	25	caspase-3	caspase-3	NUM
bjp-59809	24	26	activity	activity	NOUN
bjp-59809	24	27	in	in	ADP
bjp-59809	24	28	human	human	ADJ
bjp-59809	24	29	glioblastoma	glioblastoma	NOUN
bjp-59809	24	30	multiforme	multiforme	NOUN
bjp-59809	24	31	cells	cell	NOUN
bjp-59809	24	32	ebru	ebru	VERB
bjp-59809	24	33	güçlü	güçlü	NOUN
bjp-59809	24	34	,	,	PUNCT
bjp-59809	24	35	i̇lknur	i̇lknur	VERB
bjp-59809	24	36	çınar	çınar	PROPN
bjp-59809	24	37	ayan	ayan	PROPN
bjp-59809	24	38	and	and	CCONJ
bjp-59809	24	39	hasibe	hasibe	VERB
bjp-59809	24	40	vural	vural	PROPN
bjp-59809	24	41	department	department	PROPN
bjp-59809	24	42	of	of	ADP
bjp-59809	24	43	medical	medical	ADJ
bjp-59809	24	44	biology	biology	NOUN
bjp-59809	24	45	,	,	PUNCT
bjp-59809	24	46	meram	meram	NOUN
bjp-59809	24	47	faculty	faculty	NOUN
bjp-59809	24	48	of	of	ADP
bjp-59809	24	49	medicine	medicine	NOUN
bjp-59809	24	50	,	,	PUNCT
bjp-59809	24	51	necmettin	necmettin	PROPN
bjp-59809	24	52	erbakan	erbakan	PROPN
bjp-59809	24	53	university	university	PROPN
bjp-59809	24	54	,	,	PUNCT
bjp-59809	24	55	konya	konya	PROPN
bjp-59809	24	56	,	,	PUNCT
bjp-59809	24	57	turkey	turkey	PROPN
bjp-59809	24	58	.	.	PUNCT
bjp-59809	25	1	this	this	DET
bjp-59809	25	2	work	work	NOUN
bjp-59809	25	3	is	be	AUX
bjp-59809	25	4	licensed	license	VERB
bjp-59809	25	5	under	under	ADP
bjp-59809	25	6	a	a	DET
bjp-59809	25	7	creative	creative	ADJ
bjp-59809	25	8	commons	common	NOUN
bjp-59809	25	9	attribution	attribution	NOUN
bjp-59809	25	10	4.0	4.0	NUM
bjp-59809	25	11	license	license	NOUN
bjp-59809	25	12	.	.	PUNCT
bjp-59809	26	1	you	you	PRON
bjp-59809	26	2	are	be	AUX
bjp-59809	26	3	free	free	ADJ
bjp-59809	26	4	to	to	PART
bjp-59809	26	5	copy	copy	VERB
bjp-59809	26	6	,	,	PUNCT
bjp-59809	26	7	distribute	distribute	VERB
bjp-59809	26	8	and	and	CCONJ
bjp-59809	26	9	perform	perform	VERB
bjp-59809	26	10	the	the	DET
bjp-59809	26	11	work	work	NOUN
bjp-59809	26	12	.	.	PUNCT
bjp-59809	27	1	you	you	PRON
bjp-59809	27	2	must	must	AUX
bjp-59809	27	3	attribute	attribute	VERB
bjp-59809	27	4	the	the	DET
bjp-59809	27	5	work	work	NOUN
bjp-59809	27	6	in	in	ADP
bjp-59809	27	7	the	the	DET
bjp-59809	27	8	manner	manner	NOUN
bjp-59809	27	9	specified	specify	VERB
bjp-59809	27	10	by	by	ADP
bjp-59809	27	11	the	the	DET
bjp-59809	27	12	author	author	NOUN
bjp-59809	27	13	or	or	CCONJ
bjp-59809	27	14	licensor	licensor	NOUN
bjp-59809	27	15	.	.	PUNCT
bjp-59809	28	1	a	a	DET
bjp-59809	28	2	journal	journal	NOUN
bjp-59809	28	3	of	of	ADP
bjp-59809	28	4	the	the	DET
bjp-59809	28	5	bangladesh	bangladesh	NOUN
bjp-59809	28	6	pharmacological	pharmacological	ADJ
bjp-59809	28	7	society	society	NOUN
bjp-59809	28	8	(	(	PUNCT
bjp-59809	28	9	bdps	bdps	NOUN
bjp-59809	28	10	)	)	PUNCT
bjp-59809	28	11	bangladesh	bangladesh	PROPN
bjp-59809	28	12	j	j	PROPN
bjp-59809	28	13	pharmacol	pharmacol	PROPN
bjp-59809	28	14	2022	2022	NUM
bjp-59809	28	15	;	;	PUNCT
bjp-59809	28	16	17	17	NUM
bjp-59809	28	17	:	:	SYM
bjp-59809	28	18	42	42	NUM
bjp-59809	28	19	-	-	SYM
bjp-59809	28	20	50	50	NUM
bjp-59809	28	21	journal	journal	NOUN
bjp-59809	28	22	homepage	homepage	NOUN
bjp-59809	28	23	:	:	PUNCT
bjp-59809	28	24	www.banglajol.info	www.banglajol.info	PROPN
bjp-59809	28	25	;	;	PUNCT
bjp-59809	28	26	www.bdpsjournal.org	www.bdpsjournal.org	NUM
bjp-59809	28	27	abstracted	abstract	VERB
bjp-59809	28	28	/	/	SYM
bjp-59809	28	29	indexed	index	VERB
bjp-59809	28	30	in	in	ADP
bjp-59809	28	31	academic	academic	ADJ
bjp-59809	28	32	search	search	NOUN
bjp-59809	28	33	complete	complete	ADJ
bjp-59809	28	34	,	,	PUNCT
bjp-59809	28	35	agroforestry	agroforestry	NOUN
bjp-59809	28	36	abstracts	abstract	NOUN
bjp-59809	28	37	,	,	PUNCT
bjp-59809	28	38	asia	asia	PROPN
bjp-59809	28	39	journals	journal	NOUN
bjp-59809	28	40	online	online	ADV
bjp-59809	28	41	,	,	PUNCT
bjp-59809	28	42	bangladesh	bangladesh	NOUN
bjp-59809	28	43	journals	journal	NOUN
bjp-59809	28	44	online	online	ADV
bjp-59809	28	45	,	,	PUNCT
bjp-59809	28	46	biological	biological	ADJ
bjp-59809	28	47	abstracts	abstract	NOUN
bjp-59809	28	48	,	,	PUNCT
bjp-59809	28	49	biosis	biosis	NOUN
bjp-59809	28	50	previews	preview	NOUN
bjp-59809	28	51	,	,	PUNCT
bjp-59809	28	52	cab	cab	NOUN
bjp-59809	28	53	abstracts	abstract	NOUN
bjp-59809	28	54	,	,	PUNCT
bjp-59809	28	55	current	current	ADJ
bjp-59809	28	56	abstracts	abstract	NOUN
bjp-59809	28	57	,	,	PUNCT
bjp-59809	28	58	directory	directory	NOUN
bjp-59809	28	59	of	of	ADP
bjp-59809	28	60	open	open	ADJ
bjp-59809	28	61	access	access	NOUN
bjp-59809	28	62	journals	journal	NOUN
bjp-59809	28	63	,	,	PUNCT
bjp-59809	28	64	embase	embase	NOUN
bjp-59809	28	65	/	/	SYM
bjp-59809	28	66	excerpta	excerpta	NOUN
bjp-59809	28	67	medica	medica	NOUN
bjp-59809	28	68	,	,	PUNCT
bjp-59809	28	69	global	global	ADJ
bjp-59809	28	70	health	health	NOUN
bjp-59809	28	71	,	,	PUNCT
bjp-59809	28	72	google	google	PROPN
bjp-59809	28	73	scholar	scholar	NOUN
bjp-59809	28	74	,	,	PUNCT
bjp-59809	28	75	hinari	hinari	X
bjp-59809	28	76	(	(	PUNCT
bjp-59809	28	77	who	who	PRON
bjp-59809	28	78	)	)	PUNCT
bjp-59809	28	79	,	,	PUNCT
bjp-59809	28	80	international	international	ADJ
bjp-59809	28	81	pharmaceutical	pharmaceutical	ADJ
bjp-59809	28	82	abstracts	abstract	NOUN
bjp-59809	28	83	,	,	PUNCT
bjp-59809	28	84	open	open	ADJ
bjp-59809	28	85	j	j	PROPN
bjp-59809	28	86	-	-	PUNCT
bjp-59809	28	87	gate	gate	NOUN
bjp-59809	28	88	,	,	PUNCT
bjp-59809	28	89	science	science	NOUN
bjp-59809	28	90	citation	citation	NOUN
bjp-59809	28	91	index	index	NOUN
bjp-59809	28	92	expanded	expand	VERB
bjp-59809	28	93	,	,	PUNCT
bjp-59809	28	94	scopus	scopus	NOUN
bjp-59809	28	95	and	and	CCONJ
bjp-59809	28	96	social	social	ADJ
bjp-59809	28	97	sciences	sciences	PROPN
bjp-59809	28	98	citation	citation	NOUN
bjp-59809	28	99	index	index	NOUN
bjp-59809	28	100	issn	issn	PROPN
bjp-59809	28	101	:	:	PUNCT
bjp-59809	28	102	1991	1991	NUM
bjp-59809	28	103	-	-	SYM
bjp-59809	28	104	0088	0088	NUM
bjp-59809	28	105	george	george	PROPN
bjp-59809	28	106	and	and	CCONJ
bjp-59809	28	107	ahmad	ahmad	PROPN
bjp-59809	28	108	,	,	PUNCT
bjp-59809	28	109	2016	2016	NUM
bjp-59809	28	110	)	)	PUNCT
bjp-59809	28	111	.	.	PUNCT
bjp-59809	29	1	sirts	sirt	NOUN
bjp-59809	29	2	are	be	AUX
bjp-59809	29	3	also	also	ADV
bjp-59809	29	4	associated	associate	VERB
bjp-59809	29	5	with	with	ADP
bjp-59809	29	6	various	various	ADJ
bjp-59809	29	7	age	age	NOUN
bjp-59809	29	8	-	-	PUNCT
bjp-59809	29	9	related	relate	VERB
bjp-59809	29	10	diseases	disease	NOUN
bjp-59809	29	11	such	such	ADJ
bjp-59809	29	12	as	as	ADP
bjp-59809	29	13	metabolic	metabolic	NOUN
bjp-59809	29	14	disorders	disorder	NOUN
bjp-59809	29	15	,	,	PUNCT
bjp-59809	29	16	neurodegenerative	neurodegenerative	ADJ
bjp-59809	29	17	disorders	disorder	NOUN
bjp-59809	29	18	,	,	PUNCT
bjp-59809	29	19	cardiovascular	cardiovascular	ADJ
bjp-59809	29	20	disorders	disorder	NOUN
bjp-59809	29	21	,	,	PUNCT
bjp-59809	29	22	and	and	CCONJ
bjp-59809	29	23	cancer	cancer	NOUN
bjp-59809	29	24	(	(	PUNCT
bjp-59809	29	25	westphal	westphal	PROPN
bjp-59809	29	26	et	et	PROPN
bjp-59809	29	27	al	al	PROPN
bjp-59809	29	28	.	.	PROPN
bjp-59809	29	29	,	,	PUNCT
bjp-59809	29	30	2007	2007	NUM
bjp-59809	29	31	;	;	PUNCT
bjp-59809	29	32	morris	morris	PROPN
bjp-59809	29	33	,	,	PUNCT
bjp-59809	29	34	2012	2012	NUM
bjp-59809	29	35	)	)	PUNCT
bjp-59809	29	36	.	.	PUNCT
bjp-59809	30	1	however	however	ADV
bjp-59809	30	2	,	,	PUNCT
bjp-59809	30	3	the	the	DET
bjp-59809	30	4	role	role	NOUN
bjp-59809	30	5	of	of	ADP
bjp-59809	30	6	sirts	sirt	NOUN
bjp-59809	30	7	in	in	ADP
bjp-59809	30	8	cancer	cancer	NOUN
bjp-59809	30	9	is	be	AUX
bjp-59809	30	10	controversial	controversial	ADJ
bjp-59809	30	11	and	and	CCONJ
bjp-59809	30	12	complex	complex	ADJ
bjp-59809	30	13	.	.	PUNCT
bjp-59809	31	1	it	it	PRON
bjp-59809	31	2	is	be	AUX
bjp-59809	31	3	thought	think	VERB
bjp-59809	31	4	that	that	SCONJ
bjp-59809	31	5	the	the	DET
bjp-59809	31	6	efficiency	efficiency	NOUN
bjp-59809	31	7	of	of	ADP
bjp-59809	31	8	sirts	sirt	NOUN
bjp-59809	31	9	in	in	ADP
bjp-59809	31	10	cancer	cancer	NOUN
bjp-59809	31	11	may	may	AUX
bjp-59809	31	12	be	be	AUX
bjp-59809	31	13	related	relate	VERB
bjp-59809	31	14	to	to	ADP
bjp-59809	31	15	various	various	ADJ
bjp-59809	31	16	signaling	signal	VERB
bjp-59809	31	17	pathways	pathway	NOUN
bjp-59809	31	18	as	as	ADV
bjp-59809	31	19	well	well	ADV
bjp-59809	31	20	as	as	ADP
bjp-59809	31	21	depending	depend	VERB
bjp-59809	31	22	on	on	ADP
bjp-59809	31	23	the	the	DET
bjp-59809	31	24	cancer	cancer	NOUN
bjp-59809	31	25	type	type	NOUN
bjp-59809	31	26	(	(	PUNCT
bjp-59809	31	27	zhu	zhu	X
bjp-59809	31	28	et	et	PROPN
bjp-59809	31	29	al	al	PROPN
bjp-59809	31	30	.	.	PROPN
bjp-59809	31	31	,	,	PUNCT
bjp-59809	31	32	2019	2019	NUM
bjp-59809	31	33	;	;	PUNCT
bjp-59809	31	34	aventaggiato	aventaggiato	NOUN
bjp-59809	31	35	et	et	PROPN
bjp-59809	31	36	al	al	PROPN
bjp-59809	31	37	.	.	PROPN
bjp-59809	31	38	,	,	PUNCT
bjp-59809	31	39	2021	2021	NUM
bjp-59809	31	40	)	)	PUNCT
bjp-59809	31	41	.	.	PUNCT
bjp-59809	32	1	therefore	therefore	ADV
bjp-59809	32	2	,	,	PUNCT
bjp-59809	32	3	sirts	sirt	NOUN
bjp-59809	32	4	,	,	PUNCT
bjp-59809	32	5	including	include	VERB
bjp-59809	32	6	sirt2	sirt2	PROPN
bjp-59809	32	7	,	,	PUNCT
bjp-59809	32	8	can	can	AUX
bjp-59809	32	9	be	be	AUX
bjp-59809	32	10	considered	consider	VERB
bjp-59809	32	11	both	both	PRON
bjp-59809	32	12	tumor	tumor	NOUN
bjp-59809	32	13	suppressors	suppressor	NOUN
bjp-59809	32	14	and	and	CCONJ
bjp-59809	32	15	tumor	tumor	NOUN
bjp-59809	32	16	promoters	promoter	NOUN
bjp-59809	32	17	.	.	PUNCT
bjp-59809	33	1	however	however	ADV
bjp-59809	33	2	,	,	PUNCT
bjp-59809	33	3	the	the	DET
bjp-59809	33	4	expression	expression	NOUN
bjp-59809	33	5	of	of	ADP
bjp-59809	33	6	sirt2	sirt2	PROPN
bjp-59809	33	7	,	,	PUNCT
bjp-59809	33	8	which	which	PRON
bjp-59809	33	9	is	be	AUX
bjp-59809	33	10	expressed	express	VERB
bjp-59809	33	11	in	in	ADP
bjp-59809	33	12	a	a	DET
bjp-59809	33	13	wide	wide	ADJ
bjp-59809	33	14	variety	variety	NOUN
bjp-59809	33	15	of	of	ADP
bjp-59809	33	16	tissues	tissue	NOUN
bjp-59809	33	17	,	,	PUNCT
bjp-59809	33	18	especially	especially	ADV
bjp-59809	33	19	the	the	DET
bjp-59809	33	20	brain	brain	NOUN
bjp-59809	33	21	,	,	PUNCT
bjp-59809	33	22	is	be	AUX
bjp-59809	33	23	higher	high	ADJ
bjp-59809	33	24	than	than	ADP
bjp-59809	33	25	the	the	DET
bjp-59809	33	26	normal	normal	ADJ
bjp-59809	33	27	tissue	tissue	NOUN
bjp-59809	33	28	in	in	ADP
bjp-59809	33	29	neuroblastoma	neuroblastoma	NOUN
bjp-59809	33	30	,	,	PUNCT
bjp-59809	33	31	uveal	uveal	ADJ
bjp-59809	33	32	melanoma	melanoma	NOUN
bjp-59809	33	33	,	,	PUNCT
bjp-59809	33	34	renal	renal	ADJ
bjp-59809	33	35	cell	cell	NOUN
bjp-59809	33	36	carcinoma	carcinoma	NOUN
bjp-59809	33	37	,	,	PUNCT
bjp-59809	33	38	and	and	CCONJ
bjp-59809	33	39	acute	acute	ADJ
bjp-59809	33	40	myeloid	myeloid	NOUN
bjp-59809	33	41	leukemia	leukemia	NOUN
bjp-59809	33	42	(	(	PUNCT
bjp-59809	33	43	wang	wang	PROPN
bjp-59809	33	44	et	et	PROPN
bjp-59809	33	45	al	al	PROPN
bjp-59809	33	46	.	.	PROPN
bjp-59809	33	47	,	,	PUNCT
bjp-59809	33	48	2019	2019	NUM
bjp-59809	33	49	;	;	PUNCT
bjp-59809	33	50	chen	chen	PROPN
bjp-59809	33	51	et	et	PROPN
bjp-59809	33	52	al	al	PROPN
bjp-59809	33	53	.	.	PROPN
bjp-59809	33	54	,	,	PUNCT
bjp-59809	33	55	2020	2020	NUM
bjp-59809	33	56	)	)	PUNCT
bjp-59809	33	57	.	.	PUNCT
bjp-59809	34	1	moreover	moreover	ADV
bjp-59809	34	2	,	,	PUNCT
bjp-59809	34	3	sirt2	sirt2	PROPN
bjp-59809	34	4	is	be	AUX
bjp-59809	34	5	effective	effective	ADJ
bjp-59809	34	6	in	in	ADP
bjp-59809	34	7	the	the	DET
bjp-59809	34	8	proliferation	proliferation	NOUN
bjp-59809	34	9	of	of	ADP
bjp-59809	34	10	glioblastoma	glioblastoma	NOUN
bjp-59809	34	11	cells	cell	NOUN
bjp-59809	34	12	(	(	PUNCT
bjp-59809	34	13	funato	funato	X
bjp-59809	34	14	et	et	PROPN
bjp-59809	34	15	al	al	PROPN
bjp-59809	34	16	.	.	PROPN
bjp-59809	34	17	,	,	PUNCT
bjp-59809	34	18	2018	2018	NUM
bjp-59809	34	19	)	)	PUNCT
bjp-59809	34	20	.	.	PUNCT
bjp-59809	35	1	therefore	therefore	ADV
bjp-59809	35	2	,	,	PUNCT
bjp-59809	35	3	targeting	target	VERB
bjp-59809	35	4	sirt2	sirt2	NOUN
bjp-59809	35	5	with	with	ADP
bjp-59809	35	6	various	various	ADJ
bjp-59809	35	7	small	small	ADJ
bjp-59809	35	8	inhibitors	inhibitor	NOUN
bjp-59809	35	9	in	in	ADP
bjp-59809	35	10	cancer	cancer	NOUN
bjp-59809	35	11	types	type	NOUN
bjp-59809	35	12	,	,	PUNCT
bjp-59809	35	13	where	where	SCONJ
bjp-59809	35	14	it	it	PRON
bjp-59809	35	15	is	be	AUX
bjp-59809	35	16	highly	highly	ADV
bjp-59809	35	17	expressed	express	VERB
bjp-59809	35	18	or	or	CCONJ
bjp-59809	35	19	effective	effective	ADJ
bjp-59809	35	20	during	during	ADP
bjp-59809	35	21	tumorigenesis	tumorigenesis	NOUN
bjp-59809	35	22	,	,	PUNCT
bjp-59809	35	23	may	may	AUX
bjp-59809	35	24	be	be	AUX
bjp-59809	35	25	an	an	DET
bjp-59809	35	26	important	important	ADJ
bjp-59809	35	27	therapeutic	therapeutic	ADJ
bjp-59809	35	28	approach	approach	NOUN
bjp-59809	35	29	.	.	PUNCT
bjp-59809	36	1	indeed	indeed	ADV
bjp-59809	36	2	,	,	PUNCT
bjp-59809	36	3	pharmacological	pharmacological	ADJ
bjp-59809	36	4	inhibition	inhibition	NOUN
bjp-59809	36	5	of	of	ADP
bjp-59809	36	6	sirt2	sirt2	PROPN
bjp-59809	36	7	has	have	AUX
bjp-59809	36	8	been	be	AUX
bjp-59809	36	9	shown	show	VERB
bjp-59809	36	10	to	to	PART
bjp-59809	36	11	inhibit	inhibit	VERB
bjp-59809	36	12	the	the	DET
bjp-59809	36	13	growth	growth	NOUN
bjp-59809	36	14	of	of	ADP
bjp-59809	36	15	various	various	ADJ
bjp-59809	36	16	cancer	cancer	NOUN
bjp-59809	36	17	cells	cell	NOUN
bjp-59809	36	18	(	(	PUNCT
bjp-59809	36	19	cheon	cheon	PROPN
bjp-59809	36	20	et	et	PROPN
bjp-59809	36	21	al	al	PROPN
bjp-59809	36	22	.	.	PROPN
bjp-59809	36	23	,	,	PUNCT
bjp-59809	36	24	2015	2015	NUM
bjp-59809	36	25	;	;	PUNCT
bjp-59809	36	26	kozako	kozako	PROPN
bjp-59809	36	27	et	et	PROPN
bjp-59809	36	28	al	al	PROPN
bjp-59809	36	29	.	.	PROPN
bjp-59809	36	30	,	,	PUNCT
bjp-59809	36	31	2018	2018	NUM
bjp-59809	36	32	;	;	PUNCT
bjp-59809	36	33	ma	ma	PROPN
bjp-59809	36	34	et	et	PROPN
bjp-59809	36	35	al	al	PROPN
bjp-59809	36	36	.	.	PROPN
bjp-59809	36	37	,	,	PUNCT
bjp-59809	36	38	2018	2018	NUM
bjp-59809	36	39	)	)	PUNCT
bjp-59809	36	40	.	.	PUNCT
bjp-59809	37	1	therefore	therefore	ADV
bjp-59809	37	2	,	,	PUNCT
bjp-59809	37	3	it	it	PRON
bjp-59809	37	4	was	be	AUX
bjp-59809	37	5	aimed	aim	VERB
bjp-59809	37	6	to	to	PART
bjp-59809	37	7	investigate	investigate	VERB
bjp-59809	37	8	the	the	DET
bjp-59809	37	9	anti	anti	ADJ
bjp-59809	37	10	-	-	ADJ
bjp-59809	37	11	cancer	cancer	ADJ
bjp-59809	37	12	effect	effect	NOUN
bjp-59809	37	13	of	of	ADP
bjp-59809	37	14	ak-7	ak-7	PROPN
bjp-59809	37	15	,	,	PUNCT
bjp-59809	37	16	a	a	DET
bjp-59809	37	17	sirt2	sirt2	NOUN
bjp-59809	37	18	inhibitor	inhibitor	NOUN
bjp-59809	37	19	,	,	PUNCT
bjp-59809	37	20	on	on	ADP
bjp-59809	37	21	u87	u87	ADJ
bjp-59809	37	22	human	human	ADJ
bjp-59809	37	23	glioblastoma	glioblastoma	NOUN
bjp-59809	37	24	multiforme	multiforme	NOUN
bjp-59809	37	25	cells	cell	NOUN
bjp-59809	37	26	.	.	PUNCT
bjp-59809	38	1	for	for	ADP
bjp-59809	38	2	this	this	PRON
bjp-59809	38	3	,	,	PUNCT
bjp-59809	38	4	the	the	DET
bjp-59809	38	5	effect	effect	NOUN
bjp-59809	38	6	of	of	ADP
bjp-59809	38	7	ak-7	ak-7	ADP
bjp-59809	38	8	on	on	ADP
bjp-59809	38	9	proliferation	proliferation	NOUN
bjp-59809	38	10	and	and	CCONJ
bjp-59809	38	11	colony	colony	NOUN
bjp-59809	38	12	forming	form	VERB
bjp-59809	38	13	capacity	capacity	NOUN
bjp-59809	38	14	of	of	ADP
bjp-59809	38	15	glioblastoma	glioblastoma	NOUN
bjp-59809	38	16	multiforme	multiforme	NOUN
bjp-59809	38	17	cells	cell	NOUN
bjp-59809	38	18	was	be	AUX
bjp-59809	38	19	determined	determine	VERB
bjp-59809	38	20	and	and	CCONJ
bjp-59809	38	21	the	the	DET
bjp-59809	38	22	apoptotic	apoptotic	ADJ
bjp-59809	38	23	effect	effect	NOUN
bjp-59809	38	24	of	of	ADP
bjp-59809	38	25	ak-7	ak-7	ADV
bjp-59809	38	26	was	be	AUX
bjp-59809	38	27	evaluated	evaluate	VERB
bjp-59809	38	28	with	with	ADP
bjp-59809	38	29	various	various	ADJ
bjp-59809	38	30	apoptosis	apoptosis	NOUN
bjp-59809	38	31	-	-	PUNCT
bjp-59809	38	32	related	relate	VERB
bjp-59809	38	33	assays	assay	NOUN
bjp-59809	38	34	.	.	PUNCT
bjp-59809	39	1	materials	material	NOUN
bjp-59809	39	2	and	and	CCONJ
bjp-59809	39	3	methods	method	NOUN
bjp-59809	39	4	cell	cell	NOUN
bjp-59809	39	5	culture	culture	NOUN
bjp-59809	39	6	the	the	DET
bjp-59809	39	7	u87	u87	ADJ
bjp-59809	39	8	glioblastoma	glioblastoma	NOUN
bjp-59809	39	9	multiforme	multiforme	NOUN
bjp-59809	39	10	cell	cell	NOUN
bjp-59809	39	11	line	line	NOUN
bjp-59809	39	12	used	use	VERB
bjp-59809	39	13	in	in	ADP
bjp-59809	39	14	this	this	DET
bjp-59809	39	15	study	study	NOUN
bjp-59809	39	16	was	be	AUX
bjp-59809	39	17	obtained	obtain	VERB
bjp-59809	39	18	from	from	ADP
bjp-59809	39	19	atcc	atcc	NOUN
bjp-59809	39	20	.	.	PUNCT
bjp-59809	40	1	the	the	DET
bjp-59809	40	2	cells	cell	NOUN
bjp-59809	40	3	were	be	AUX
bjp-59809	40	4	cultured	cultured	ADJ
bjp-59809	40	5	in	in	ADP
bjp-59809	40	6	high	high	ADJ
bjp-59809	40	7	glucose	glucose	NOUN
bjp-59809	40	8	(	(	PUNCT
bjp-59809	40	9	4.5	4.5	NUM
bjp-59809	40	10	g	g	NOUN
bjp-59809	40	11	/	/	SYM
bjp-59809	40	12	l	l	NOUN
bjp-59809	40	13	)	)	PUNCT
bjp-59809	40	14	dmem	dmem	VERB
bjp-59809	40	15	supplemented	supplement	VERB
bjp-59809	40	16	with	with	ADP
bjp-59809	40	17	10%fetal	10%fetal	NUM
bjp-59809	40	18	bovine	bovine	NOUN
bjp-59809	40	19	serum	serum	NOUN
bjp-59809	40	20	(	(	PUNCT
bjp-59809	40	21	fbs	fbs	PROPN
bjp-59809	40	22	)	)	PUNCT
bjp-59809	40	23	and	and	CCONJ
bjp-59809	40	24	1%penicillin	1%penicillin	NUM
bjp-59809	40	25	-	-	PUNCT
bjp-59809	40	26	streptomycin	streptomycin	PROPN
bjp-59809	40	27	(	(	PUNCT
bjp-59809	40	28	v	v	NOUN
bjp-59809	40	29	/	/	SYM
bjp-59809	40	30	v	v	NOUN
bjp-59809	40	31	)	)	PUNCT
bjp-59809	40	32	at	at	ADP
bjp-59809	40	33	37	37	NUM
bjp-59809	40	34	°	°	ADP
bjp-59809	40	35	c	c	NOUN
bjp-59809	40	36	in	in	ADP
bjp-59809	40	37	a	a	DET
bjp-59809	40	38	humidified	humidify	VERB
bjp-59809	40	39	atmosphere	atmosphere	NOUN
bjp-59809	40	40	containing	contain	VERB
bjp-59809	40	41	5%co2	5%co2	PROPN
bjp-59809	40	42	.	.	PUNCT
bjp-59809	41	1	the	the	DET
bjp-59809	41	2	culture	culture	NOUN
bjp-59809	41	3	medium	medium	NOUN
bjp-59809	41	4	was	be	AUX
bjp-59809	41	5	refreshed	refresh	VERB
bjp-59809	41	6	every	every	DET
bjp-59809	41	7	2	2	NUM
bjp-59809	41	8	days	day	NOUN
bjp-59809	41	9	and	and	CCONJ
bjp-59809	41	10	cells	cell	NOUN
bjp-59809	41	11	were	be	AUX
bjp-59809	41	12	passaged	passage	VERB
bjp-59809	41	13	when	when	SCONJ
bjp-59809	41	14	confluency	confluency	NOUN
bjp-59809	41	15	reached	reach	VERB
bjp-59809	41	16	80	80	NUM
bjp-59809	41	17	%	%	NOUN
bjp-59809	41	18	.	.	PUNCT
bjp-59809	42	1	cell	cell	NOUN
bjp-59809	42	2	viability	viability	NOUN
bjp-59809	42	3	to	to	PART
bjp-59809	42	4	determine	determine	VERB
bjp-59809	42	5	the	the	DET
bjp-59809	42	6	cytotoxic	cytotoxic	ADJ
bjp-59809	42	7	ic50	ic50	PROPN
bjp-59809	42	8	(	(	PUNCT
bjp-59809	42	9	the	the	DET
bjp-59809	42	10	half	half	ADV
bjp-59809	42	11	-	-	PUNCT
bjp-59809	42	12	maximal	maximal	ADJ
bjp-59809	42	13	inhibitory	inhibitory	ADJ
bjp-59809	42	14	concentration	concentration	NOUN
bjp-59809	42	15	)	)	PUNCT
bjp-59809	42	16	dose	dose	NOUN
bjp-59809	42	17	of	of	ADP
bjp-59809	42	18	ak-7	ak-7	ADP
bjp-59809	42	19	(	(	PUNCT
bjp-59809	42	20	tocris	tocris	NOUN
bjp-59809	42	21	bioscience	bioscience	PROPN
bjp-59809	42	22	)	)	PUNCT
bjp-59809	42	23	on	on	ADP
bjp-59809	42	24	u87	u87	ADJ
bjp-59809	42	25	cell	cell	NOUN
bjp-59809	42	26	line	line	NOUN
bjp-59809	42	27	,	,	PUNCT
bjp-59809	42	28	firstly	firstly	ADV
bjp-59809	42	29	,	,	PUNCT
bjp-59809	42	30	the	the	DET
bjp-59809	42	31	cells	cell	NOUN
bjp-59809	42	32	were	be	AUX
bjp-59809	42	33	seeded	seed	VERB
bjp-59809	42	34	in	in	ADP
bjp-59809	42	35	a	a	DET
bjp-59809	42	36	96well	96well	NUM
bjp-59809	42	37	plate	plate	NOUN
bjp-59809	42	38	at	at	ADP
bjp-59809	42	39	a	a	DET
bjp-59809	42	40	density	density	NOUN
bjp-59809	42	41	of	of	ADP
bjp-59809	42	42	2	2	NUM
bjp-59809	42	43	x	x	SYM
bjp-59809	42	44	103	103	NUM
bjp-59809	42	45	cells	cell	NOUN
bjp-59809	42	46	/	/	SYM
bjp-59809	42	47	well	well	ADV
bjp-59809	42	48	and	and	CCONJ
bjp-59809	42	49	incubated	incubate	VERB
bjp-59809	42	50	at	at	ADP
bjp-59809	42	51	37	37	NUM
bjp-59809	42	52	°	°	ADP
bjp-59809	42	53	c	c	NOUN
bjp-59809	42	54	for	for	ADP
bjp-59809	42	55	24	24	NUM
bjp-59809	42	56	hours	hour	NOUN
bjp-59809	42	57	.	.	PUNCT
bjp-59809	43	1	then	then	ADV
bjp-59809	43	2	,	,	PUNCT
bjp-59809	43	3	cells	cell	NOUN
bjp-59809	43	4	were	be	AUX
bjp-59809	43	5	treated	treat	VERB
bjp-59809	43	6	with	with	ADP
bjp-59809	43	7	ak-7	ak-7	ADP
bjp-59809	43	8	at	at	ADP
bjp-59809	43	9	different	different	ADJ
bjp-59809	43	10	concentrations	concentration	NOUN
bjp-59809	43	11	(	(	PUNCT
bjp-59809	43	12	5–250	5–250	NUM
bjp-59809	43	13	μm	μm	NOUN
bjp-59809	43	14	)	)	PUNCT
bjp-59809	43	15	for	for	ADP
bjp-59809	43	16	24	24	NUM
bjp-59809	43	17	,	,	PUNCT
bjp-59809	43	18	48	48	NUM
bjp-59809	43	19	,	,	PUNCT
bjp-59809	43	20	and	and	CCONJ
bjp-59809	43	21	72	72	NUM
bjp-59809	43	22	hours	hour	NOUN
bjp-59809	43	23	.	.	PUNCT
bjp-59809	44	1	following	follow	VERB
bjp-59809	44	2	treatment	treatment	NOUN
bjp-59809	44	3	,	,	PUNCT
bjp-59809	44	4	150	150	NUM
bjp-59809	44	5	μl	μl	PRON
bjp-59809	44	6	of	of	ADP
bjp-59809	44	7	xtt	xtt	NOUN
bjp-59809	44	8	solution	solution	NOUN
bjp-59809	44	9	was	be	AUX
bjp-59809	44	10	added	add	VERB
bjp-59809	44	11	to	to	ADP
bjp-59809	44	12	each	each	DET
bjp-59809	44	13	well	well	ADV
bjp-59809	44	14	and	and	CCONJ
bjp-59809	44	15	incubated	incubate	VERB
bjp-59809	44	16	at	at	ADP
bjp-59809	44	17	37	37	NUM
bjp-59809	44	18	°	°	ADP
bjp-59809	44	19	c	c	NOUN
bjp-59809	44	20	for	for	ADP
bjp-59809	44	21	4	4	NUM
bjp-59809	44	22	hours	hour	NOUN
bjp-59809	44	23	in	in	ADP
bjp-59809	44	24	the	the	DET
bjp-59809	44	25	darkness	darkness	NOUN
bjp-59809	44	26	.	.	PUNCT
bjp-59809	45	1	after	after	ADP
bjp-59809	45	2	the	the	DET
bjp-59809	45	3	incubation	incubation	NOUN
bjp-59809	45	4	,	,	PUNCT
bjp-59809	45	5	the	the	DET
bjp-59809	45	6	absorbance	absorbance	NOUN
bjp-59809	45	7	of	of	ADP
bjp-59809	45	8	each	each	DET
bjp-59809	45	9	sample	sample	NOUN
bjp-59809	45	10	was	be	AUX
bjp-59809	45	11	measured	measure	VERB
bjp-59809	45	12	at	at	ADP
bjp-59809	45	13	a	a	DET
bjp-59809	45	14	wavelength	wavelength	NOUN
bjp-59809	45	15	of	of	ADP
bjp-59809	45	16	450	450	NUM
bjp-59809	45	17	nm	nm	NOUN
bjp-59809	45	18	and	and	CCONJ
bjp-59809	45	19	630	630	NUM
bjp-59809	45	20	 	 	SPACE
bjp-59809	45	21	nm	nm	NOUN
bjp-59809	45	22	using	use	VERB
bjp-59809	45	23	a	a	DET
bjp-59809	45	24	microplate	microplate	NOUN
bjp-59809	45	25	reader	reader	NOUN
bjp-59809	45	26	(	(	PUNCT
bjp-59809	45	27	biotek	biotek	NOUN
bjp-59809	45	28	,	,	PUNCT
bjp-59809	45	29	epoch	epoch	NOUN
bjp-59809	45	30	)	)	PUNCT
bjp-59809	45	31	.	.	PUNCT
bjp-59809	46	1	colony	colony	NOUN
bjp-59809	46	2	formation	formation	NOUN
bjp-59809	46	3	assay	assay	VERB
bjp-59809	46	4	the	the	DET
bjp-59809	46	5	colony	colony	NOUN
bjp-59809	46	6	formation	formation	NOUN
bjp-59809	46	7	assay	assay	NOUN
bjp-59809	46	8	was	be	AUX
bjp-59809	46	9	performed	perform	VERB
bjp-59809	46	10	to	to	PART
bjp-59809	46	11	evaluate	evaluate	VERB
bjp-59809	46	12	the	the	DET
bjp-59809	46	13	effect	effect	NOUN
bjp-59809	46	14	of	of	ADP
bjp-59809	46	15	75	75	NUM
bjp-59809	46	16	and	and	CCONJ
bjp-59809	46	17	100	100	NUM
bjp-59809	46	18	µm	µm	ADP
bjp-59809	46	19	doses	dose	NOUN
bjp-59809	46	20	of	of	ADP
bjp-59809	46	21	ak-7	ak-7	ADV
bjp-59809	46	22	,	,	PUNCT
bjp-59809	46	23	on	on	ADP
bjp-59809	46	24	colony	colony	NOUN
bjp-59809	46	25	forming	form	VERB
bjp-59809	46	26	capacity	capacity	NOUN
bjp-59809	46	27	in	in	ADP
bjp-59809	46	28	u87	u87	ADJ
bjp-59809	46	29	glioblastoma	glioblastoma	NOUN
bjp-59809	46	30	multiforme	multiforme	NOUN
bjp-59809	46	31	cells	cell	NOUN
bjp-59809	46	32	.	.	PUNCT
bjp-59809	47	1	u87	u87	ADJ
bjp-59809	47	2	cells	cell	NOUN
bjp-59809	47	3	were	be	AUX
bjp-59809	47	4	seeded	seed	VERB
bjp-59809	47	5	in	in	ADP
bjp-59809	47	6	6	6	NUM
bjp-59809	47	7	-	-	PUNCT
bjp-59809	47	8	well	well	NOUN
bjp-59809	47	9	plates	plate	NOUN
bjp-59809	47	10	at	at	ADP
bjp-59809	47	11	a	a	DET
bjp-59809	47	12	density	density	NOUN
bjp-59809	47	13	of	of	ADP
bjp-59809	47	14	2	2	NUM
bjp-59809	47	15	x	x	SYM
bjp-59809	47	16	103	103	NUM
bjp-59809	47	17	cells	cell	NOUN
bjp-59809	47	18	/	/	SYM
bjp-59809	47	19	well	well	ADV
bjp-59809	47	20	.	.	PUNCT
bjp-59809	48	1	after	after	SCONJ
bjp-59809	48	2	24	24	NUM
bjp-59809	48	3	hours	hour	NOUN
bjp-59809	48	4	of	of	ADP
bjp-59809	48	5	incubation	incubation	NOUN
bjp-59809	48	6	,	,	PUNCT
bjp-59809	48	7	75	75	NUM
bjp-59809	48	8	and	and	CCONJ
bjp-59809	48	9	100	100	NUM
bjp-59809	48	10	µm	µm	ADP
bjp-59809	48	11	doses	dose	NOUN
bjp-59809	48	12	of	of	ADP
bjp-59809	48	13	ak-7	ak-7	ADV
bjp-59809	48	14	were	be	AUX
bjp-59809	48	15	treated	treat	VERB
bjp-59809	48	16	in	in	ADP
bjp-59809	48	17	triplicate	triplicate	NOUN
bjp-59809	48	18	for	for	ADP
bjp-59809	48	19	48	48	NUM
bjp-59809	48	20	h.	h.	NOUN
bjp-59809	48	21	the	the	DET
bjp-59809	48	22	culture	culture	NOUN
bjp-59809	48	23	medium	medium	NOUN
bjp-59809	48	24	was	be	AUX
bjp-59809	48	25	refreshed	refresh	VERB
bjp-59809	48	26	every	every	DET
bjp-59809	48	27	other	other	ADJ
bjp-59809	48	28	day	day	NOUN
bjp-59809	48	29	until	until	SCONJ
bjp-59809	48	30	colonies	colony	NOUN
bjp-59809	48	31	were	be	AUX
bjp-59809	48	32	formed	form	VERB
bjp-59809	48	33	.	.	PUNCT
bjp-59809	49	1	after	after	ADP
bjp-59809	49	2	8	8	NUM
bjp-59809	49	3	days	day	NOUN
bjp-59809	49	4	of	of	ADP
bjp-59809	49	5	culture	culture	NOUN
bjp-59809	49	6	,	,	PUNCT
bjp-59809	49	7	the	the	DET
bjp-59809	49	8	cells	cell	NOUN
bjp-59809	49	9	were	be	AUX
bjp-59809	49	10	washed	wash	VERB
bjp-59809	49	11	with	with	ADP
bjp-59809	49	12	pbs	pbs	PROPN
bjp-59809	49	13	.	.	PUNCT
bjp-59809	50	1	then	then	ADV
bjp-59809	50	2	cells	cell	NOUN
bjp-59809	50	3	were	be	AUX
bjp-59809	50	4	fixed	fix	VERB
bjp-59809	50	5	with	with	ADP
bjp-59809	50	6	100	100	NUM
bjp-59809	50	7	%	%	NOUN
bjp-59809	50	8	methanol	methanol	NOUN
bjp-59809	50	9	at	at	ADP
bjp-59809	50	10	-20	-20	NUM
bjp-59809	50	11	°	°	NOUN
bjp-59809	50	12	c	c	NOUN
bjp-59809	50	13	and	and	CCONJ
bjp-59809	50	14	stained	stain	VERB
bjp-59809	50	15	with	with	ADP
bjp-59809	50	16	1.0	1.0	NUM
bjp-59809	50	17	%	%	NOUN
bjp-59809	50	18	crystal	crystal	NOUN
bjp-59809	50	19	violet	violet	NOUN
bjp-59809	50	20	for	for	ADP
bjp-59809	50	21	10	10	NUM
bjp-59809	50	22	min	min	NOUN
bjp-59809	50	23	.	.	PROPN
bjp-59809	50	24	after	after	SCONJ
bjp-59809	50	25	the	the	DET
bjp-59809	50	26	cells	cell	NOUN
bjp-59809	50	27	were	be	AUX
bjp-59809	50	28	photographed	photograph	VERB
bjp-59809	50	29	under	under	ADP
bjp-59809	50	30	an	an	DET
bjp-59809	50	31	inverted	inverted	ADJ
bjp-59809	50	32	microscope	microscope	NOUN
bjp-59809	50	33	,	,	PUNCT
bjp-59809	50	34	each	each	DET
bjp-59809	50	35	well	well	NOUN
bjp-59809	50	36	of	of	ADP
bjp-59809	50	37	the	the	DET
bjp-59809	50	38	dose	dose	NOUN
bjp-59809	50	39	and	and	CCONJ
bjp-59809	50	40	control	control	NOUN
bjp-59809	50	41	groups	group	NOUN
bjp-59809	50	42	was	be	AUX
bjp-59809	50	43	counted	count	VERB
bjp-59809	50	44	.	.	PUNCT
bjp-59809	51	1	the	the	DET
bjp-59809	51	2	average	average	ADJ
bjp-59809	51	3	colony	colony	NOUN
bjp-59809	51	4	numbers	number	NOUN
bjp-59809	51	5	of	of	ADP
bjp-59809	51	6	each	each	DET
bjp-59809	51	7	group	group	NOUN
bjp-59809	51	8	were	be	AUX
bjp-59809	51	9	calculated	calculate	VERB
bjp-59809	51	10	and	and	CCONJ
bjp-59809	51	11	compared	compare	VERB
bjp-59809	51	12	statistically	statistically	ADV
bjp-59809	51	13	.	.	PUNCT
bjp-59809	52	1	annexin	annexin	PROPN
bjp-59809	52	2	v/7	v/7	NOUN
bjp-59809	52	3	-	-	PUNCT
bjp-59809	52	4	aad	aad	VERB
bjp-59809	52	5	analysis	analysis	NOUN
bjp-59809	52	6	to	to	PART
bjp-59809	52	7	evaluate	evaluate	VERB
bjp-59809	52	8	the	the	DET
bjp-59809	52	9	apoptotic	apoptotic	ADJ
bjp-59809	52	10	effect	effect	NOUN
bjp-59809	52	11	of	of	ADP
bjp-59809	52	12	ak-7	ak-7	ADP
bjp-59809	52	13	on	on	ADP
bjp-59809	52	14	u87	u87	ADJ
bjp-59809	52	15	cells	cell	NOUN
bjp-59809	52	16	,	,	PUNCT
bjp-59809	52	17	fitc	fitc	NOUN
bjp-59809	52	18	annexin	annexin	NOUN
bjp-59809	52	19	v	v	ADP
bjp-59809	52	20	apoptosis	apoptosis	NOUN
bjp-59809	52	21	detection	detection	NOUN
bjp-59809	52	22	kit	kit	NOUN
bjp-59809	52	23	with	with	ADP
bjp-59809	52	24	7	7	NUM
bjp-59809	52	25	-	-	PUNCT
bjp-59809	52	26	aad	aad	NOUN
bjp-59809	52	27	(	(	PUNCT
bjp-59809	52	28	biolegend	biolegend	PROPN
bjp-59809	52	29	,	,	PUNCT
bjp-59809	52	30	640922	640922	NUM
bjp-59809	52	31	)	)	PUNCT
bjp-59809	52	32	was	be	AUX
bjp-59809	52	33	used	use	VERB
bjp-59809	52	34	.	.	PUNCT
bjp-59809	53	1	fitc	fitc	NOUN
bjp-59809	53	2	annexin	annexin	NOUN
bjp-59809	53	3	v	v	ADP
bjp-59809	53	4	apoptosis	apoptosis	NOUN
bjp-59809	53	5	detection	detection	NOUN
bjp-59809	53	6	kit	kit	NOUN
bjp-59809	53	7	with	with	ADP
bjp-59809	53	8	7	7	NUM
bjp-59809	53	9	-	-	PUNCT
bjp-59809	53	10	aad	aad	NOUN
bjp-59809	53	11	can	can	AUX
bjp-59809	53	12	detect	detect	VERB
bjp-59809	53	13	the	the	DET
bjp-59809	53	14	rate	rate	NOUN
bjp-59809	53	15	of	of	ADP
bjp-59809	53	16	necrotic	necrotic	ADJ
bjp-59809	53	17	,	,	PUNCT
bjp-59809	53	18	early	early	ADV
bjp-59809	53	19	apoptotic	apoptotic	ADJ
bjp-59809	53	20	,	,	PUNCT
bjp-59809	53	21	and	and	CCONJ
bjp-59809	53	22	late	late	ADJ
bjp-59809	53	23	apoptotic	apoptotic	ADJ
bjp-59809	53	24	cells	cell	NOUN
bjp-59809	53	25	in	in	ADP
bjp-59809	53	26	the	the	DET
bjp-59809	53	27	cell	cell	NOUN
bjp-59809	53	28	suspension	suspension	NOUN
bjp-59809	53	29	of	of	ADP
bjp-59809	53	30	dose	dose	NOUN
bjp-59809	53	31	and	and	CCONJ
bjp-59809	53	32	control	control	PROPN
bjp-59809	53	33	group	group	NOUN
bjp-59809	53	34	.	.	PUNCT
bjp-59809	54	1	for	for	ADP
bjp-59809	54	2	this	this	DET
bjp-59809	54	3	analysis	analysis	NOUN
bjp-59809	54	4	,	,	PUNCT
bjp-59809	54	5	u87	u87	ADJ
bjp-59809	54	6	cells	cell	NOUN
bjp-59809	54	7	were	be	AUX
bjp-59809	54	8	treated	treat	VERB
bjp-59809	54	9	with	with	ADP
bjp-59809	54	10	75	75	NUM
bjp-59809	54	11	and	and	CCONJ
bjp-59809	54	12	100	100	NUM
bjp-59809	54	13	µm	µm	ADP
bjp-59809	54	14	doses	dose	NOUN
bjp-59809	54	15	of	of	ADP
bjp-59809	54	16	ak-7	ak-7	ADP
bjp-59809	54	17	for	for	ADP
bjp-59809	54	18	48	48	NUM
bjp-59809	54	19	hours	hour	NOUN
bjp-59809	54	20	and	and	CCONJ
bjp-59809	54	21	then	then	ADV
bjp-59809	54	22	washed	wash	VERB
bjp-59809	54	23	2	2	NUM
bjp-59809	54	24	times	time	NOUN
bjp-59809	54	25	with	with	ADP
bjp-59809	54	26	cold	cold	ADJ
bjp-59809	54	27	biolegend	biolegend	NOUN
bjp-59809	54	28	's	's	PART
bjp-59809	54	29	cell	cell	NOUN
bjp-59809	54	30	staining	stain	VERB
bjp-59809	54	31	buffer	buffer	NOUN
bjp-59809	54	32	.	.	PUNCT
bjp-59809	55	1	the	the	DET
bjp-59809	55	2	cells	cell	NOUN
bjp-59809	55	3	were	be	AUX
bjp-59809	55	4	resuspended	resuspend	VERB
bjp-59809	55	5	with	with	ADP
bjp-59809	55	6	annexin	annexin	NOUN
bjp-59809	55	7	-	-	PUNCT
bjp-59809	55	8	v	v	NOUN
bjp-59809	55	9	-	-	PUNCT
bjp-59809	55	10	binding	bind	VERB
bjp-59809	55	11	buffer	buffer	NOUN
bjp-59809	55	12	and	and	CCONJ
bjp-59809	55	13	after	after	SCONJ
bjp-59809	55	14	the	the	DET
bjp-59809	55	15	cells	cell	NOUN
bjp-59809	55	16	were	be	AUX
bjp-59809	55	17	transferred	transfer	VERB
bjp-59809	55	18	to	to	ADP
bjp-59809	55	19	a	a	DET
bjp-59809	55	20	flow	flow	NOUN
bjp-59809	55	21	cytometry	cytometry	NOUN
bjp-59809	55	22	tube	tube	NOUN
bjp-59809	55	23	,	,	PUNCT
bjp-59809	55	24	5	5	NUM
bjp-59809	55	25	µl	µl	NOUN
bjp-59809	55	26	of	of	ADP
bjp-59809	55	27	fitc	fitc	PROPN
bjp-59809	55	28	annexin	annexin	PROPN
bjp-59809	55	29	v	v	PROPN
bjp-59809	55	30	and	and	CCONJ
bjp-59809	55	31	5	5	NUM
bjp-59809	55	32	µl	µl	NOUN
bjp-59809	55	33	of	of	ADP
bjp-59809	55	34	7	7	NUM
bjp-59809	55	35	-	-	PUNCT
bjp-59809	55	36	aad	aad	NOUN
bjp-59809	55	37	viability	viability	NOUN
bjp-59809	55	38	staining	stain	VERB
bjp-59809	55	39	solution	solution	NOUN
bjp-59809	55	40	were	be	AUX
bjp-59809	55	41	added	add	VERB
bjp-59809	55	42	to	to	ADP
bjp-59809	55	43	100	100	NUM
bjp-59809	55	44	µl	µl	ADP
bjp-59809	55	45	of	of	ADP
bjp-59809	55	46	cell	cell	NOUN
bjp-59809	55	47	suspension	suspension	NOUN
bjp-59809	55	48	.	.	PUNCT
bjp-59809	56	1	finally	finally	ADV
bjp-59809	56	2	,	,	PUNCT
bjp-59809	56	3	the	the	DET
bjp-59809	56	4	apoptotic	apoptotic	ADJ
bjp-59809	56	5	effect	effect	NOUN
bjp-59809	56	6	of	of	ADP
bjp-59809	56	7	ak-7	ak-7	ADV
bjp-59809	56	8	was	be	AUX
bjp-59809	56	9	measured	measure	VERB
bjp-59809	56	10	by	by	ADP
bjp-59809	56	11	flow	flow	NOUN
bjp-59809	56	12	cytometry	cytometry	NOUN
bjp-59809	56	13	using	use	VERB
bjp-59809	56	14	facscanto	facscanto	PROPN
bjp-59809	56	15	(	(	PUNCT
bjp-59809	56	16	bd	bd	PROPN
bjp-59809	56	17	biosciences	bioscience	NOUN
bjp-59809	56	18	)	)	PUNCT
bjp-59809	56	19	.	.	PUNCT
bjp-59809	57	1	cell	cell	NOUN
bjp-59809	57	2	death	death	NOUN
bjp-59809	57	3	detection	detection	NOUN
bjp-59809	57	4	assay	assay	VERB
bjp-59809	57	5	cell	cell	NOUN
bjp-59809	57	6	death	death	NOUN
bjp-59809	57	7	detection	detection	NOUN
bjp-59809	57	8	elisaplus	elisaplus	ADV
bjp-59809	57	9	(	(	PUNCT
bjp-59809	57	10	roche	roche	NOUN
bjp-59809	57	11	,	,	PUNCT
bjp-59809	57	12	11774425001	11774425001	NUM
bjp-59809	57	13	)	)	PUNCT
bjp-59809	57	14	assay	assay	NOUN
bjp-59809	57	15	was	be	AUX
bjp-59809	57	16	used	use	VERB
bjp-59809	57	17	to	to	PART
bjp-59809	57	18	evaluate	evaluate	VERB
bjp-59809	57	19	the	the	DET
bjp-59809	57	20	apoptotic	apoptotic	ADJ
bjp-59809	57	21	effect	effect	NOUN
bjp-59809	57	22	in	in	ADP
bjp-59809	57	23	u87	u87	ADJ
bjp-59809	57	24	glioblastoma	glioblastoma	NOUN
bjp-59809	57	25	multiforme	multiforme	NOUN
bjp-59809	57	26	cells	cell	NOUN
bjp-59809	57	27	treated	treat	VERB
bjp-59809	57	28	with	with	ADP
bjp-59809	57	29	two	two	NUM
bjp-59809	57	30	different	different	ADJ
bjp-59809	57	31	doses	dose	NOUN
bjp-59809	57	32	(	(	PUNCT
bjp-59809	57	33	75	75	NUM
bjp-59809	57	34	and	and	CCONJ
bjp-59809	57	35	100	100	NUM
bjp-59809	57	36	µm	µm	NOUN
bjp-59809	57	37	)	)	PUNCT
bjp-59809	57	38	of	of	ADP
bjp-59809	57	39	ak-7	ak-7	PROPN
bjp-59809	57	40	.	.	PUNCT
bjp-59809	58	1	this	this	DET
bjp-59809	58	2	assay	assay	NOUN
bjp-59809	58	3	allows	allow	VERB
bjp-59809	58	4	the	the	DET
bjp-59809	58	5	quantitative	quantitative	ADJ
bjp-59809	58	6	detection	detection	NOUN
bjp-59809	58	7	of	of	ADP
bjp-59809	58	8	dna	dna	PROPN
bjp-59809	58	9	fragmentation	fragmentation	NOUN
bjp-59809	58	10	occurring	occur	VERB
bjp-59809	58	11	during	during	ADP
bjp-59809	58	12	apoptosis	apoptosis	NOUN
bjp-59809	58	13	.	.	PUNCT
bjp-59809	59	1	for	for	ADP
bjp-59809	59	2	the	the	DET
bjp-59809	59	3	analysis	analysis	NOUN
bjp-59809	59	4	of	of	ADP
bjp-59809	59	5	this	this	DET
bjp-59809	59	6	assay	assay	NOUN
bjp-59809	59	7	,	,	PUNCT
bjp-59809	59	8	cells	cell	NOUN
bjp-59809	59	9	were	be	AUX
bjp-59809	59	10	first	first	ADV
bjp-59809	59	11	seeded	seed	VERB
bjp-59809	59	12	in	in	ADP
bjp-59809	59	13	24	24	NUM
bjp-59809	59	14	-	-	PUNCT
bjp-59809	59	15	well	well	NOUN
bjp-59809	59	16	plates	plate	NOUN
bjp-59809	59	17	at	at	ADP
bjp-59809	59	18	a	a	DET
bjp-59809	59	19	density	density	NOUN
bjp-59809	59	20	of	of	ADP
bjp-59809	59	21	5	5	NUM
bjp-59809	59	22	x	x	SYM
bjp-59809	59	23	104	104	NUM
bjp-59809	59	24	cells	cell	NOUN
bjp-59809	59	25	/	/	SYM
bjp-59809	60	1	well	well	ADV
bjp-59809	60	2	and	and	CCONJ
bjp-59809	60	3	then	then	ADV
bjp-59809	60	4	incubated	incubate	VERB
bjp-59809	60	5	for	for	ADP
bjp-59809	60	6	24	24	NUM
bjp-59809	60	7	hours	hour	NOUN
bjp-59809	60	8	.	.	PUNCT
bjp-59809	61	1	afterward	afterward	ADV
bjp-59809	61	2	,	,	PUNCT
bjp-59809	61	3	the	the	DET
bjp-59809	61	4	cells	cell	NOUN
bjp-59809	61	5	were	be	AUX
bjp-59809	61	6	treated	treat	VERB
bjp-59809	61	7	with	with	ADP
bjp-59809	61	8	75	75	NUM
bjp-59809	61	9	and	and	CCONJ
bjp-59809	61	10	100	100	NUM
bjp-59809	61	11	µm	µm	ADP
bjp-59809	61	12	doses	dose	NOUN
bjp-59809	61	13	of	of	ADP
bjp-59809	61	14	ak-7	ak-7	ADP
bjp-59809	61	15	for	for	ADP
bjp-59809	61	16	48	48	NUM
bjp-59809	61	17	hours	hour	NOUN
bjp-59809	61	18	.	.	PUNCT
bjp-59809	62	1	at	at	ADP
bjp-59809	62	2	the	the	DET
bjp-59809	62	3	end	end	NOUN
bjp-59809	62	4	of	of	ADP
bjp-59809	62	5	48	48	NUM
bjp-59809	62	6	hours	hour	NOUN
bjp-59809	62	7	,	,	PUNCT
bjp-59809	62	8	cells	cell	NOUN
bjp-59809	62	9	in	in	ADP
bjp-59809	62	10	each	each	DET
bjp-59809	62	11	dose	dose	NOUN
bjp-59809	62	12	group	group	NOUN
bjp-59809	62	13	and	and	CCONJ
bjp-59809	62	14	control	control	NOUN
bjp-59809	62	15	group	group	NOUN
bjp-59809	62	16	were	be	AUX
bjp-59809	62	17	counted	count	VERB
bjp-59809	62	18	again	again	ADV
bjp-59809	62	19	and	and	CCONJ
bjp-59809	62	20	seeded	seed	VERB
bjp-59809	62	21	in	in	ADP
bjp-59809	62	22	96	96	NUM
bjp-59809	62	23	-	-	PUNCT
bjp-59809	62	24	well	well	NOUN
bjp-59809	62	25	plates	plate	NOUN
bjp-59809	62	26	at	at	ADP
bjp-59809	62	27	a	a	DET
bjp-59809	62	28	density	density	NOUN
bjp-59809	62	29	of	of	ADP
bjp-59809	62	30	104	104	NUM
bjp-59809	62	31	cells	cell	NOUN
bjp-59809	62	32	/	/	SYM
bjp-59809	62	33	well	well	ADV
bjp-59809	62	34	,	,	PUNCT
bjp-59809	62	35	and	and	CCONJ
bjp-59809	62	36	then	then	ADV
bjp-59809	62	37	incubated	incubate	VERB
bjp-59809	62	38	at	at	ADP
bjp-59809	62	39	37	37	NUM
bjp-59809	62	40	°	°	ADP
bjp-59809	62	41	c	c	NOUN
bjp-59809	62	42	for	for	ADP
bjp-59809	62	43	4	4	NUM
bjp-59809	62	44	hours	hour	NOUN
bjp-59809	62	45	.	.	PUNCT
bjp-59809	63	1	after	after	ADP
bjp-59809	63	2	the	the	DET
bjp-59809	63	3	incubation	incubation	NOUN
bjp-59809	63	4	period	period	NOUN
bjp-59809	63	5	,	,	PUNCT
bjp-59809	63	6	the	the	DET
bjp-59809	63	7	microplate	microplate	NOUN
bjp-59809	63	8	was	be	AUX
bjp-59809	63	9	centrifuged	centrifuge	VERB
bjp-59809	63	10	at	at	ADP
bjp-59809	63	11	200	200	NUM
bjp-59809	63	12	g	g	NOUN
bjp-59809	63	13	for	for	ADP
bjp-59809	63	14	10	10	NUM
bjp-59809	63	15	min	min	NOUN
bjp-59809	63	16	.	.	NOUN
bjp-59809	64	1	after	after	ADP
bjp-59809	64	2	removing	remove	VERB
bjp-59809	64	3	the	the	DET
bjp-59809	64	4	supernatant	supernatant	NOUN
bjp-59809	64	5	,	,	PUNCT
bjp-59809	64	6	each	each	DET
bjp-59809	64	7	sample	sample	NOUN
bjp-59809	64	8	was	be	AUX
bjp-59809	64	9	resuspended	resuspend	VERB
bjp-59809	64	10	with	with	ADP
bjp-59809	64	11	200	200	NUM
bjp-59809	64	12	µl	µl	NOUN
bjp-59809	64	13	of	of	ADP
bjp-59809	64	14	lysis	lysis	NOUN
bjp-59809	64	15	buffer	buffer	NOUN
bjp-59809	64	16	and	and	CCONJ
bjp-59809	64	17	the	the	DET
bjp-59809	64	18	microplate	microplate	NOUN
bjp-59809	64	19	was	be	AUX
bjp-59809	64	20	incubated	incubate	VERB
bjp-59809	64	21	for	for	ADP
bjp-59809	64	22	30	30	NUM
bjp-59809	64	23	min	min	NOUN
bjp-59809	64	24	at	at	ADP
bjp-59809	64	25	room	room	NOUN
bjp-59809	64	26	temperature	temperature	NOUN
bjp-59809	64	27	.	.	PUNCT
bjp-59809	65	1	after	after	SCONJ
bjp-59809	65	2	the	the	DET
bjp-59809	65	3	microplate	microplate	NOUN
bjp-59809	65	4	was	be	AUX
bjp-59809	65	5	centrifuged	centrifuge	VERB
bjp-59809	65	6	at	at	ADP
bjp-59809	65	7	200	200	NUM
bjp-59809	65	8	x	x	SYM
bjp-59809	65	9	g	g	NOUN
bjp-59809	65	10	for	for	ADP
bjp-59809	65	11	10	10	NUM
bjp-59809	65	12	min	min	NOUN
bjp-59809	65	13	,	,	PUNCT
bjp-59809	65	14	20	20	NUM
bjp-59809	65	15	µl	µl	NOUN
bjp-59809	65	16	of	of	ADP
bjp-59809	65	17	each	each	DET
bjp-59809	65	18	sample	sample	NOUN
bjp-59809	65	19	's	's	PART
bjp-59809	65	20	lysate	lysate	NOUN
bjp-59809	65	21	was	be	AUX
bjp-59809	65	22	transferred	transfer	VERB
bjp-59809	65	23	to	to	ADP
bjp-59809	65	24	the	the	DET
bjp-59809	65	25	streptavidin	streptavidin	ADJ
bjp-59809	65	26	-	-	ADJ
bjp-59809	65	27	coated	coated	ADJ
bjp-59809	65	28	microplate	microplate	NOUN
bjp-59809	65	29	wells	wells	PROPN
bjp-59809	65	30	,	,	PUNCT
bjp-59809	65	31	and	and	CCONJ
bjp-59809	65	32	80	80	NUM
bjp-59809	65	33	µl	µl	NOUN
bjp-59809	65	34	of	of	ADP
bjp-59809	65	35	immunoreagent	immunoreagent	NOUN
bjp-59809	65	36	was	be	AUX
bjp-59809	65	37	added	add	VERB
bjp-59809	65	38	to	to	ADP
bjp-59809	65	39	the	the	DET
bjp-59809	65	40	bangladesh	bangladesh	PROPN
bjp-59809	65	41	j	j	PROPN
bjp-59809	65	42	pharmacol	pharmacol	PROPN
bjp-59809	65	43	2022	2022	NUM
bjp-59809	65	44	;	;	PUNCT
bjp-59809	65	45	17	17	NUM
bjp-59809	65	46	:	:	SYM
bjp-59809	65	47	42	42	NUM
bjp-59809	65	48	-	-	SYM
bjp-59809	65	49	50	50	NUM
bjp-59809	65	50	43	43	NUM
bjp-59809	65	51	sample	sample	NOUN
bjp-59809	65	52	wells	well	NOUN
bjp-59809	65	53	.	.	PUNCT
bjp-59809	66	1	after	after	ADP
bjp-59809	66	2	incubation	incubation	NOUN
bjp-59809	66	3	at	at	ADP
bjp-59809	66	4	300	300	NUM
bjp-59809	66	5	rpm	rpm	NOUN
bjp-59809	66	6	for	for	ADP
bjp-59809	66	7	2	2	NUM
bjp-59809	66	8	hours	hour	NOUN
bjp-59809	66	9	in	in	ADP
bjp-59809	66	10	a	a	DET
bjp-59809	66	11	shaker	shaker	NOUN
bjp-59809	66	12	at	at	ADP
bjp-59809	66	13	rt	rt	PROPN
bjp-59809	66	14	,	,	PUNCT
bjp-59809	66	15	it	it	PRON
bjp-59809	66	16	was	be	AUX
bjp-59809	66	17	washed	wash	VERB
bjp-59809	66	18	3	3	NUM
bjp-59809	66	19	times	time	NOUN
bjp-59809	66	20	with	with	ADP
bjp-59809	66	21	incubation	incubation	NOUN
bjp-59809	66	22	buffer	buffer	NOUN
bjp-59809	66	23	.	.	PUNCT
bjp-59809	67	1	100	100	NUM
bjp-59809	67	2	µl	µl	NOUN
bjp-59809	67	3	of	of	ADP
bjp-59809	67	4	abts	abt	NOUN
bjp-59809	67	5	solution	solution	NOUN
bjp-59809	67	6	was	be	AUX
bjp-59809	67	7	added	add	VERB
bjp-59809	67	8	to	to	ADP
bjp-59809	67	9	each	each	DET
bjp-59809	67	10	well	well	ADV
bjp-59809	67	11	and	and	CCONJ
bjp-59809	67	12	incubated	incubate	VERB
bjp-59809	67	13	for	for	ADP
bjp-59809	67	14	20	20	NUM
bjp-59809	67	15	min	min	NOUN
bjp-59809	67	16	in	in	ADP
bjp-59809	67	17	a	a	DET
bjp-59809	67	18	shaker	shaker	NOUN
bjp-59809	67	19	at	at	ADP
bjp-59809	67	20	250	250	NUM
bjp-59809	67	21	rpm	rpm	NOUN
bjp-59809	67	22	.	.	PUNCT
bjp-59809	68	1	after	after	ADP
bjp-59809	68	2	incubation	incubation	NOUN
bjp-59809	68	3	,	,	PUNCT
bjp-59809	68	4	100	100	NUM
bjp-59809	68	5	µl	µl	NOUN
bjp-59809	68	6	of	of	ADP
bjp-59809	68	7	abts	abt	NOUN
bjp-59809	68	8	stop	stop	VERB
bjp-59809	68	9	solution	solution	NOUN
bjp-59809	68	10	was	be	AUX
bjp-59809	68	11	added	add	VERB
bjp-59809	68	12	and	and	CCONJ
bjp-59809	68	13	the	the	DET
bjp-59809	68	14	absorbance	absorbance	NOUN
bjp-59809	68	15	values	value	NOUN
bjp-59809	68	16	(	(	PUNCT
bjp-59809	68	17	od	od	NOUN
bjp-59809	68	18	)	)	PUNCT
bjp-59809	68	19	of	of	ADP
bjp-59809	68	20	each	each	DET
bjp-59809	68	21	sample	sample	NOUN
bjp-59809	68	22	were	be	AUX
bjp-59809	68	23	measured	measure	VERB
bjp-59809	68	24	in	in	ADP
bjp-59809	68	25	the	the	DET
bjp-59809	68	26	elisa	elisa	NOUN
bjp-59809	68	27	reader	reader	NOUN
bjp-59809	68	28	(	(	PUNCT
bjp-59809	68	29	biotek	biotek	NOUN
bjp-59809	68	30	,	,	PUNCT
bjp-59809	68	31	epoch	epoch	NOUN
bjp-59809	68	32	)	)	PUNCT
bjp-59809	68	33	at	at	ADP
bjp-59809	68	34	a	a	DET
bjp-59809	68	35	wavelength	wavelength	NOUN
bjp-59809	68	36	of	of	ADP
bjp-59809	68	37	405	405	NUM
bjp-59809	68	38	nm	nm	NOUN
bjp-59809	68	39	and	and	CCONJ
bjp-59809	68	40	a	a	DET
bjp-59809	68	41	reference	reference	NOUN
bjp-59809	68	42	range	range	NOUN
bjp-59809	68	43	of	of	ADP
bjp-59809	68	44	490	490	NUM
bjp-59809	68	45	nm	nm	NOUN
bjp-59809	68	46	.	.	PUNCT
bjp-59809	69	1	caspase-3	caspase-3	NUM
bjp-59809	69	2	activity	activity	NOUN
bjp-59809	69	3	assay	assay	VERB
bjp-59809	69	4	the	the	DET
bjp-59809	69	5	effects	effect	NOUN
bjp-59809	69	6	of	of	ADP
bjp-59809	69	7	ak-7	ak-7	ADP
bjp-59809	69	8	on	on	ADP
bjp-59809	69	9	caspase-3	caspase-3	NUM
bjp-59809	69	10	activity	activity	NOUN
bjp-59809	69	11	were	be	AUX
bjp-59809	69	12	performed	perform	VERB
bjp-59809	69	13	using	use	VERB
bjp-59809	69	14	caspase-3	caspase-3	NUM
bjp-59809	69	15	assay	assay	NOUN
bjp-59809	69	16	kit	kit	NOUN
bjp-59809	69	17	(	(	PUNCT
bjp-59809	69	18	biovision	biovision	NOUN
bjp-59809	69	19	,	,	PUNCT
bjp-59809	69	20	k106	k106	PROPN
bjp-59809	69	21	)	)	PUNCT
bjp-59809	69	22	according	accord	VERB
bjp-59809	69	23	to	to	ADP
bjp-59809	69	24	the	the	DET
bjp-59809	69	25	manufacturer	manufacturer	NOUN
bjp-59809	69	26	's	's	PART
bjp-59809	69	27	instructions	instruction	NOUN
bjp-59809	69	28	.	.	PUNCT
bjp-59809	70	1	u87	u87	ADJ
bjp-59809	70	2	cells	cell	NOUN
bjp-59809	70	3	,	,	PUNCT
bjp-59809	70	4	which	which	PRON
bjp-59809	70	5	were	be	AUX
bjp-59809	70	6	first	first	ADV
bjp-59809	70	7	seeded	seed	VERB
bjp-59809	70	8	in	in	ADP
bjp-59809	70	9	6	6	NUM
bjp-59809	70	10	-	-	PUNCT
bjp-59809	70	11	well	well	NOUN
bjp-59809	70	12	plates	plate	NOUN
bjp-59809	70	13	at	at	ADP
bjp-59809	70	14	a	a	DET
bjp-59809	70	15	density	density	NOUN
bjp-59809	70	16	of	of	ADP
bjp-59809	70	17	5	5	NUM
bjp-59809	70	18	x	x	SYM
bjp-59809	70	19	105	105	NUM
bjp-59809	70	20	cells	cell	NOUN
bjp-59809	70	21	/	/	SYM
bjp-59809	70	22	well	well	ADV
bjp-59809	70	23	,	,	PUNCT
bjp-59809	70	24	were	be	AUX
bjp-59809	70	25	treated	treat	VERB
bjp-59809	70	26	with	with	ADP
bjp-59809	70	27	75	75	NUM
bjp-59809	70	28	and	and	CCONJ
bjp-59809	70	29	100	100	NUM
bjp-59809	70	30	µm	µm	ADP
bjp-59809	70	31	doses	dose	NOUN
bjp-59809	70	32	of	of	ADP
bjp-59809	70	33	ak-7	ak-7	ADP
bjp-59809	70	34	for	for	ADP
bjp-59809	70	35	48	48	NUM
bjp-59809	70	36	hours	hour	NOUN
bjp-59809	70	37	,	,	PUNCT
bjp-59809	70	38	then	then	ADV
bjp-59809	70	39	cells	cell	NOUN
bjp-59809	70	40	were	be	AUX
bjp-59809	70	41	trypsinized	trypsinize	VERB
bjp-59809	70	42	and	and	CCONJ
bjp-59809	70	43	resuspended	resuspend	VERB
bjp-59809	70	44	with	with	ADP
bjp-59809	70	45	pellet	pellet	NOUN
bjp-59809	70	46	cell	cell	NOUN
bjp-59809	70	47	lysis	lysis	NOUN
bjp-59809	70	48	buffer	buffer	NOUN
bjp-59809	70	49	and	and	CCONJ
bjp-59809	70	50	incubated	incubate	VERB
bjp-59809	70	51	on	on	ADP
bjp-59809	70	52	ice	ice	NOUN
bjp-59809	70	53	for	for	ADP
bjp-59809	70	54	10	10	NUM
bjp-59809	70	55	min	min	NOUN
bjp-59809	70	56	.	.	PROPN
bjp-59809	70	57	after	after	SCONJ
bjp-59809	70	58	the	the	DET
bjp-59809	70	59	cells	cell	NOUN
bjp-59809	70	60	were	be	AUX
bjp-59809	70	61	centrifuged	centrifuge	VERB
bjp-59809	70	62	at	at	ADP
bjp-59809	70	63	10000	10000	NUM
bjp-59809	70	64	x	x	SYM
bjp-59809	70	65	g	g	NOUN
bjp-59809	70	66	for	for	ADP
bjp-59809	70	67	1	1	NUM
bjp-59809	70	68	min	min	NOUN
bjp-59809	70	69	,	,	PUNCT
bjp-59809	70	70	the	the	DET
bjp-59809	70	71	supernatant	supernatant	NOUN
bjp-59809	70	72	was	be	AUX
bjp-59809	70	73	transferred	transfer	VERB
bjp-59809	70	74	to	to	ADP
bjp-59809	70	75	a	a	DET
bjp-59809	70	76	new	new	ADJ
bjp-59809	70	77	tube	tube	NOUN
bjp-59809	70	78	and	and	CCONJ
bjp-59809	70	79	the	the	DET
bjp-59809	70	80	concentration	concentration	NOUN
bjp-59809	70	81	of	of	ADP
bjp-59809	70	82	each	each	DET
bjp-59809	70	83	sample	sample	NOUN
bjp-59809	70	84	was	be	AUX
bjp-59809	70	85	measured	measure	VERB
bjp-59809	70	86	at	at	ADP
bjp-59809	70	87	200	200	NUM
bjp-59809	70	88	µg	µg	NOUN
bjp-59809	70	89	.	.	PUNCT
bjp-59809	71	1	after	after	ADP
bjp-59809	71	2	adding	add	VERB
bjp-59809	71	3	50	50	NUM
bjp-59809	71	4	µl	µl	NOUN
bjp-59809	71	5	of	of	ADP
bjp-59809	71	6	2x	2x	NUM
bjp-59809	71	7	reaction	reaction	NOUN
bjp-59809	71	8	buffer	buffer	NOUN
bjp-59809	71	9	(	(	PUNCT
bjp-59809	71	10	containing	contain	VERB
bjp-59809	71	11	10	10	NUM
bjp-59809	71	12	mm	mm	NUM
bjp-59809	71	13	dtt	dtt	NOUN
bjp-59809	71	14	)	)	PUNCT
bjp-59809	71	15	and	and	CCONJ
bjp-59809	71	16	5	5	NUM
bjp-59809	71	17	µl	µl	NOUN
bjp-59809	71	18	of	of	ADP
bjp-59809	71	19	4	4	NUM
bjp-59809	71	20	mm	mm	NOUN
bjp-59809	71	21	devd	devd	NOUN
bjp-59809	71	22	-	-	PUNCT
bjp-59809	71	23	pna	pna	NOUN
bjp-59809	71	24	substrate	substrate	NOUN
bjp-59809	71	25	on	on	ADP
bjp-59809	71	26	each	each	DET
bjp-59809	71	27	sample	sample	NOUN
bjp-59809	71	28	,	,	PUNCT
bjp-59809	71	29	it	it	PRON
bjp-59809	71	30	was	be	AUX
bjp-59809	71	31	incubated	incubate	VERB
bjp-59809	71	32	at	at	ADP
bjp-59809	71	33	37	37	NUM
bjp-59809	71	34	°	°	ADP
bjp-59809	71	35	c	c	NOUN
bjp-59809	71	36	for	for	ADP
bjp-59809	71	37	2	2	NUM
bjp-59809	71	38	hours	hour	NOUN
bjp-59809	71	39	.	.	PUNCT
bjp-59809	72	1	the	the	DET
bjp-59809	72	2	cleaved	cleaved	NOUN
bjp-59809	72	3	paranitroanilide	paranitroanilide	VERB
bjp-59809	72	4	with	with	ADP
bjp-59809	72	5	caspase-3	caspase-3	NUM
bjp-59809	72	6	activity	activity	NOUN
bjp-59809	72	7	in	in	ADP
bjp-59809	72	8	each	each	DET
bjp-59809	72	9	sample	sample	NOUN
bjp-59809	72	10	was	be	AUX
bjp-59809	72	11	measured	measure	VERB
bjp-59809	72	12	with	with	ADP
bjp-59809	72	13	a	a	DET
bjp-59809	72	14	microplate	microplate	NOUN
bjp-59809	72	15	reader	reader	NOUN
bjp-59809	72	16	at	at	ADP
bjp-59809	72	17	400	400	NUM
bjp-59809	72	18	nm	nm	ADJ
bjp-59809	72	19	wavelength	wavelength	NOUN
bjp-59809	72	20	(	(	PUNCT
bjp-59809	72	21	biotek	biotek	NOUN
bjp-59809	72	22	,	,	PUNCT
bjp-59809	72	23	epoch	epoch	NOUN
bjp-59809	72	24	)	)	PUNCT
bjp-59809	72	25	.	.	PUNCT
bjp-59809	73	1	statistical	statistical	ADJ
bjp-59809	73	2	analysis	analysis	NOUN
bjp-59809	73	3	all	all	DET
bjp-59809	73	4	experiments	experiment	NOUN
bjp-59809	73	5	were	be	AUX
bjp-59809	73	6	performed	perform	VERB
bjp-59809	73	7	in	in	ADP
bjp-59809	73	8	triplicate	triplicate	NOUN
bjp-59809	73	9	and	and	CCONJ
bjp-59809	73	10	all	all	DET
bjp-59809	73	11	data	datum	NOUN
bjp-59809	73	12	were	be	AUX
bjp-59809	73	13	presented	present	VERB
bjp-59809	73	14	as	as	ADP
bjp-59809	73	15	mean	mean	ADJ
bjp-59809	73	16	values	value	NOUN
bjp-59809	73	17	±	±	NOUN
bjp-59809	73	18	standard	standard	ADJ
bjp-59809	73	19	deviation	deviation	NOUN
bjp-59809	73	20	(	(	PUNCT
bjp-59809	73	21	sd	sd	NOUN
bjp-59809	73	22	)	)	PUNCT
bjp-59809	73	23	.	.	PUNCT
bjp-59809	74	1	the	the	DET
bjp-59809	74	2	differences	difference	NOUN
bjp-59809	74	3	between	between	ADP
bjp-59809	74	4	groups	group	NOUN
bjp-59809	74	5	was	be	AUX
bjp-59809	74	6	box	box	NOUN
bjp-59809	74	7	1	1	NUM
bjp-59809	74	8	:	:	PUNCT
bjp-59809	74	9	qrt	qrt	ADJ
bjp-59809	74	10	-	-	PUNCT
bjp-59809	74	11	pcr	pcr	ADJ
bjp-59809	74	12	principle	principle	NOUN
bjp-59809	74	13	quantitative	quantitative	ADJ
bjp-59809	74	14	real	real	ADJ
bjp-59809	74	15	time	time	NOUN
bjp-59809	74	16	polymerase	polymerase	NOUN
bjp-59809	74	17	chain	chain	NOUN
bjp-59809	74	18	reaction	reaction	NOUN
bjp-59809	74	19	(	(	PUNCT
bjp-59809	74	20	qrt	qrt	NOUN
bjp-59809	74	21	-	-	PUNCT
bjp-59809	74	22	pcr	pcr	NOUN
bjp-59809	74	23	)	)	PUNCT
bjp-59809	74	24	is	be	AUX
bjp-59809	74	25	a	a	DET
bjp-59809	74	26	method	method	NOUN
bjp-59809	74	27	that	that	PRON
bjp-59809	74	28	uses	use	VERB
bjp-59809	74	29	fluorescently	fluorescently	ADV
bjp-59809	74	30	labelled	label	VERB
bjp-59809	74	31	probes	probe	NOUN
bjp-59809	74	32	and	and	CCONJ
bjp-59809	74	33	dyes	dye	NOUN
bjp-59809	74	34	,	,	PUNCT
bjp-59809	74	35	and	and	CCONJ
bjp-59809	74	36	provides	provide	VERB
bjp-59809	74	37	results	result	NOUN
bjp-59809	74	38	related	relate	VERB
bjp-59809	74	39	to	to	ADP
bjp-59809	74	40	the	the	DET
bjp-59809	74	41	quantification	quantification	NOUN
bjp-59809	74	42	of	of	ADP
bjp-59809	74	43	nucleic	nucleic	ADJ
bjp-59809	74	44	acids	acid	NOUN
bjp-59809	74	45	by	by	ADP
bjp-59809	74	46	measuring	measure	VERB
bjp-59809	74	47	the	the	DET
bjp-59809	74	48	fluorescent	fluorescent	ADJ
bjp-59809	74	49	signal	signal	NOUN
bjp-59809	74	50	that	that	PRON
bjp-59809	74	51	increases	increase	VERB
bjp-59809	74	52	simultaneously	simultaneously	ADV
bjp-59809	74	53	with	with	ADP
bjp-59809	74	54	amplification	amplification	NOUN
bjp-59809	74	55	.	.	PUNCT
bjp-59809	75	1	qrt	qrt	ADJ
bjp-59809	75	2	-	-	PUNCT
bjp-59809	75	3	pcr	pcr	PROPN
bjp-59809	75	4	has	have	VERB
bjp-59809	75	5	a	a	DET
bjp-59809	75	6	wide	wide	ADJ
bjp-59809	75	7	range	range	NOUN
bjp-59809	75	8	of	of	ADP
bjp-59809	75	9	uses	use	NOUN
bjp-59809	75	10	.	.	PUNCT
bjp-59809	76	1	one	one	NUM
bjp-59809	76	2	of	of	ADP
bjp-59809	76	3	the	the	DET
bjp-59809	76	4	most	most	ADV
bjp-59809	76	5	common	common	ADJ
bjp-59809	76	6	uses	use	NOUN
bjp-59809	76	7	is	be	AUX
bjp-59809	76	8	the	the	DET
bjp-59809	76	9	determination	determination	NOUN
bjp-59809	76	10	of	of	ADP
bjp-59809	76	11	gene	gene	NOUN
bjp-59809	76	12	expression	expression	NOUN
bjp-59809	76	13	at	at	ADP
bjp-59809	76	14	the	the	DET
bjp-59809	76	15	mrna	mrna	PROPN
bjp-59809	76	16	level	level	NOUN
bjp-59809	76	17	.	.	PUNCT
bjp-59809	77	1	for	for	ADP
bjp-59809	77	2	this	this	PRON
bjp-59809	77	3	,	,	PUNCT
bjp-59809	77	4	first	first	ADV
bjp-59809	77	5	of	of	ADP
bjp-59809	77	6	all	all	PRON
bjp-59809	77	7	,	,	PUNCT
bjp-59809	77	8	total	total	ADJ
bjp-59809	77	9	rna	rna	NOUN
bjp-59809	77	10	isolation	isolation	NOUN
bjp-59809	77	11	is	be	AUX
bjp-59809	77	12	performed	perform	VERB
bjp-59809	77	13	.	.	PUNCT
bjp-59809	78	1	then	then	ADV
bjp-59809	78	2	cdna	cdna	PROPN
bjp-59809	78	3	is	be	AUX
bjp-59809	78	4	synthesized	synthesize	VERB
bjp-59809	78	5	from	from	ADP
bjp-59809	78	6	rna	rna	PROPN
bjp-59809	78	7	.	.	PUNCT
bjp-59809	79	1	finally	finally	ADV
bjp-59809	79	2	,	,	PUNCT
bjp-59809	79	3	the	the	DET
bjp-59809	79	4	reaction	reaction	NOUN
bjp-59809	79	5	is	be	AUX
bjp-59809	79	6	performed	perform	VERB
bjp-59809	79	7	in	in	ADP
bjp-59809	79	8	a	a	DET
bjp-59809	79	9	real	real	ADJ
bjp-59809	79	10	time	time	NOUN
bjp-59809	79	11	pcr	pcr	NOUN
bjp-59809	79	12	system	system	NOUN
bjp-59809	79	13	using	use	VERB
bjp-59809	79	14	a	a	DET
bjp-59809	79	15	master	master	NOUN
bjp-59809	79	16	mix	mix	NOUN
bjp-59809	79	17	containing	contain	VERB
bjp-59809	79	18	dye	dye	NOUN
bjp-59809	79	19	that	that	PRON
bjp-59809	79	20	can	can	AUX
bjp-59809	79	21	bind	bind	VERB
bjp-59809	79	22	to	to	ADP
bjp-59809	79	23	double	double	ADV
bjp-59809	79	24	-	-	PUNCT
bjp-59809	79	25	stranded	strand	VERB
bjp-59809	79	26	dna	dna	NOUN
bjp-59809	79	27	,	,	PUNCT
bjp-59809	79	28	forward	forward	ADV
bjp-59809	79	29	and	and	CCONJ
bjp-59809	79	30	reverse	reverse	VERB
bjp-59809	79	31	primers	primer	NOUN
bjp-59809	79	32	designed	design	VERB
bjp-59809	79	33	according	accord	VERB
bjp-59809	79	34	to	to	ADP
bjp-59809	79	35	the	the	DET
bjp-59809	79	36	target	target	NOUN
bjp-59809	79	37	gene	gene	NOUN
bjp-59809	79	38	sequences	sequence	NOUN
bjp-59809	79	39	and	and	CCONJ
bjp-59809	79	40	cdna	cdna	PROPN
bjp-59809	79	41	.	.	PUNCT
bjp-59809	80	1	the	the	DET
bjp-59809	80	2	threshold	threshold	NOUN
bjp-59809	80	3	cycle	cycle	NOUN
bjp-59809	80	4	values	value	NOUN
bjp-59809	80	5	(	(	PUNCT
bjp-59809	80	6	ct	ct	NOUN
bjp-59809	80	7	)	)	PUNCT
bjp-59809	80	8	are	be	AUX
bjp-59809	80	9	used	use	VERB
bjp-59809	80	10	for	for	ADP
bjp-59809	80	11	the	the	DET
bjp-59809	80	12	analysis	analysis	NOUN
bjp-59809	80	13	,	,	PUNCT
bjp-59809	80	14	corresponding	correspond	VERB
bjp-59809	80	15	to	to	ADP
bjp-59809	80	16	the	the	DET
bjp-59809	80	17	cycle	cycle	NOUN
bjp-59809	80	18	in	in	ADP
bjp-59809	80	19	which	which	PRON
bjp-59809	80	20	a	a	DET
bjp-59809	80	21	significant	significant	ADJ
bjp-59809	80	22	increase	increase	NOUN
bjp-59809	80	23	in	in	ADP
bjp-59809	80	24	fluorescence	fluorescence	NOUN
bjp-59809	80	25	is	be	AUX
bjp-59809	80	26	observed	observe	VERB
bjp-59809	80	27	.	.	PUNCT
bjp-59809	81	1	normalization	normalization	NOUN
bjp-59809	81	2	is	be	AUX
bjp-59809	81	3	performed	perform	VERB
bjp-59809	81	4	with	with	ADP
bjp-59809	81	5	house	house	NOUN
bjp-59809	81	6	keeping	keeping	NOUN
bjp-59809	81	7	genes	gene	NOUN
bjp-59809	81	8	.	.	PUNCT
bjp-59809	82	1	differences	difference	NOUN
bjp-59809	82	2	in	in	ADP
bjp-59809	82	3	gene	gene	NOUN
bjp-59809	82	4	expression	expression	NOUN
bjp-59809	82	5	are	be	AUX
bjp-59809	82	6	detected	detect	VERB
bjp-59809	82	7	using	use	VERB
bjp-59809	82	8	the	the	DET
bjp-59809	82	9	2	2	NUM
bjp-59809	82	10	–	–	PUNCT
bjp-59809	82	11	δδct	δδct	NOUN
bjp-59809	82	12	method	method	NOUN
bjp-59809	82	13	.	.	PUNCT
bjp-59809	83	1	requirements	requirement	NOUN
bjp-59809	83	2	cdna	cdna	PROPN
bjp-59809	83	3	synthesis	synthesis	NOUN
bjp-59809	83	4	kit	kit	NOUN
bjp-59809	83	5	;	;	PUNCT
bjp-59809	83	6	chloroform	chloroform	NOUN
bjp-59809	83	7	;	;	PUNCT
bjp-59809	83	8	dnase	dnase	VERB
bjp-59809	83	9	i	i	PRON
bjp-59809	83	10	enzyme	enzyme	VERB
bjp-59809	83	11	;	;	PUNCT
bjp-59809	83	12	dnase	dnase	VERB
bjp-59809	83	13	i	i	PRON
bjp-59809	83	14	enzyme	enzyme	NOUN
bjp-59809	83	15	buffer	buffer	NOUN
bjp-59809	83	16	;	;	PUNCT
bjp-59809	83	17	edta	edta	PROPN
bjp-59809	83	18	;	;	PUNCT
bjp-59809	83	19	eppendorf	eppendorf	PROPN
bjp-59809	83	20	tubes	tube	NOUN
bjp-59809	83	21	;	;	PUNCT
bjp-59809	83	22	ethanol	ethanol	NOUN
bjp-59809	83	23	(	(	PUNCT
bjp-59809	83	24	70	70	NUM
bjp-59809	83	25	%	%	NOUN
bjp-59809	83	26	)	)	PUNCT
bjp-59809	83	27	;	;	PUNCT
bjp-59809	83	28	isopropanol	isopropanol	NOUN
bjp-59809	83	29	;	;	PUNCT
bjp-59809	83	30	microcentrifuge	microcentrifuge	ADJ
bjp-59809	83	31	;	;	PUNCT
bjp-59809	83	32	nanodrop	nanodrop	PROPN
bjp-59809	83	33	(	(	PUNCT
bjp-59809	83	34	maestrogen	maestrogen	PROPN
bjp-59809	83	35	)	)	PUNCT
bjp-59809	83	36	;	;	PUNCT
bjp-59809	83	37	nuclease	nuclease	NOUN
bjp-59809	83	38	-free	-free	PROPN
bjp-59809	83	39	dh2o	dh2o	NOUN
bjp-59809	83	40	;	;	PUNCT
bjp-59809	83	41	pcr	pcr	NOUN
bjp-59809	83	42	tubes	tube	NOUN
bjp-59809	83	43	;	;	PUNCT
bjp-59809	83	44	real	real	ADJ
bjp-59809	83	45	-	-	PUNCT
bjp-59809	83	46	time	time	NOUN
bjp-59809	83	47	pcr	pcr	ADJ
bjp-59809	83	48	detection	detection	NOUN
bjp-59809	83	49	system	system	NOUN
bjp-59809	83	50	(	(	PUNCT
bjp-59809	83	51	biorad	biorad	NOUN
bjp-59809	83	52	cfx	cfx	PROPN
bjp-59809	83	53	connect	connect	PROPN
bjp-59809	83	54	)	)	PUNCT
bjp-59809	83	55	;	;	PUNCT
bjp-59809	83	56	qpcr	qpcr	ADJ
bjp-59809	83	57	mastermix	mastermix	NOUN
bjp-59809	83	58	;	;	PUNCT
bjp-59809	83	59	8	8	NUM
bjp-59809	83	60	-	-	PUNCT
bjp-59809	83	61	strip	strip	NOUN
bjp-59809	83	62	pcr	pcr	PROPN
bjp-59809	83	63	tubes	tube	NOUN
bjp-59809	83	64	;	;	PUNCT
bjp-59809	83	65	trizol	trizol	VERB
bjp-59809	83	66	reagent	reagent	NOUN
bjp-59809	83	67	;	;	PUNCT
bjp-59809	83	68	6	6	NUM
bjp-59809	83	69	-	-	PUNCT
bjp-59809	83	70	well	well	NOUN
bjp-59809	83	71	plate	plate	NOUN
bjp-59809	83	72	.	.	PUNCT
bjp-59809	84	1	procedure	procedure	NOUN
bjp-59809	84	2	step	step	NOUN
bjp-59809	84	3	1	1	NUM
bjp-59809	84	4	:	:	PUNCT
bjp-59809	84	5	total	total	ADJ
bjp-59809	84	6	rna	rna	NOUN
bjp-59809	84	7	isolation	isolation	NOUN
bjp-59809	84	8	media	medium	NOUN
bjp-59809	84	9	of	of	ADP
bjp-59809	84	10	cells	cell	NOUN
bjp-59809	84	11	in	in	ADP
bjp-59809	84	12	6	6	NUM
bjp-59809	84	13	-	-	PUNCT
bjp-59809	84	14	well	well	NOUN
bjp-59809	84	15	plates	plate	NOUN
bjp-59809	84	16	were	be	AUX
bjp-59809	84	17	removed	remove	VERB
bjp-59809	84	18	and	and	CCONJ
bjp-59809	84	19	500	500	NUM
bjp-59809	84	20	µl	µl	NOUN
bjp-59809	84	21	of	of	ADP
bjp-59809	84	22	trizol	trizol	ADJ
bjp-59809	84	23	reagent	reagent	NOUN
bjp-59809	84	24	was	be	AUX
bjp-59809	84	25	added	add	VERB
bjp-59809	84	26	to	to	ADP
bjp-59809	84	27	each	each	DET
bjp-59809	84	28	well	well	ADV
bjp-59809	84	29	.	.	PUNCT
bjp-59809	85	1	the	the	DET
bjp-59809	85	2	homogenate	homogenate	NOUN
bjp-59809	85	3	in	in	ADP
bjp-59809	85	4	each	each	DET
bjp-59809	85	5	well	well	ADV
bjp-59809	85	6	was	be	AUX
bjp-59809	85	7	transferred	transfer	VERB
bjp-59809	85	8	to	to	ADP
bjp-59809	85	9	eppendorf	eppendorf	PROPN
bjp-59809	85	10	tubes	tube	NOUN
bjp-59809	85	11	and	and	CCONJ
bjp-59809	85	12	incubated	incubate	VERB
bjp-59809	85	13	for	for	ADP
bjp-59809	85	14	10	10	NUM
bjp-59809	85	15	min	min	NOUN
bjp-59809	85	16	at	at	ADP
bjp-59809	85	17	room	room	NOUN
bjp-59809	85	18	temperature	temperature	NOUN
bjp-59809	85	19	.	.	PUNCT
bjp-59809	86	1	then	then	ADV
bjp-59809	86	2	,	,	PUNCT
bjp-59809	86	3	200	200	NUM
bjp-59809	86	4	μl	μl	PRON
bjp-59809	86	5	of	of	ADP
bjp-59809	86	6	chloroform	chloroform	NOUN
bjp-59809	86	7	was	be	AUX
bjp-59809	86	8	added	add	VERB
bjp-59809	86	9	to	to	ADP
bjp-59809	86	10	each	each	DET
bjp-59809	86	11	epondorf	epondorf	ADJ
bjp-59809	86	12	tube	tube	NOUN
bjp-59809	86	13	and	and	CCONJ
bjp-59809	86	14	the	the	DET
bjp-59809	86	15	tubes	tube	NOUN
bjp-59809	86	16	were	be	AUX
bjp-59809	86	17	incubated	incubate	VERB
bjp-59809	86	18	for	for	ADP
bjp-59809	86	19	15	15	NUM
bjp-59809	86	20	min	min	NOUN
bjp-59809	86	21	at	at	ADP
bjp-59809	86	22	room	room	NOUN
bjp-59809	86	23	temperature	temperature	NOUN
bjp-59809	86	24	.	.	PUNCT
bjp-59809	87	1	at	at	ADP
bjp-59809	87	2	the	the	DET
bjp-59809	87	3	end	end	NOUN
bjp-59809	87	4	of	of	ADP
bjp-59809	87	5	the	the	DET
bjp-59809	87	6	incubation	incubation	NOUN
bjp-59809	87	7	,	,	PUNCT
bjp-59809	87	8	centrifugation	centrifugation	NOUN
bjp-59809	87	9	was	be	AUX
bjp-59809	87	10	performed	perform	VERB
bjp-59809	87	11	at	at	ADP
bjp-59809	87	12	12000	12000	NUM
bjp-59809	87	13	x	x	SYM
bjp-59809	87	14	g	g	NOUN
bjp-59809	87	15	for	for	ADP
bjp-59809	87	16	15	15	NUM
bjp-59809	87	17	min	min	NOUN
bjp-59809	87	18	and	and	CCONJ
bjp-59809	87	19	the	the	DET
bjp-59809	87	20	supernatants	supernatant	NOUN
bjp-59809	87	21	were	be	AUX
bjp-59809	87	22	transferred	transfer	VERB
bjp-59809	87	23	to	to	ADP
bjp-59809	87	24	new	new	ADJ
bjp-59809	87	25	eppendorf	eppendorf	PROPN
bjp-59809	87	26	tubes	tube	NOUN
bjp-59809	87	27	.	.	PUNCT
bjp-59809	88	1	500	500	NUM
bjp-59809	88	2	μl	μl	PRON
bjp-59809	88	3	of	of	ADP
bjp-59809	88	4	isopropanol	isopropanol	NOUN
bjp-59809	88	5	was	be	AUX
bjp-59809	88	6	added	add	VERB
bjp-59809	88	7	to	to	ADP
bjp-59809	88	8	the	the	DET
bjp-59809	88	9	tubes	tube	NOUN
bjp-59809	88	10	and	and	CCONJ
bjp-59809	88	11	incubated	incubate	VERB
bjp-59809	88	12	for	for	ADP
bjp-59809	88	13	10	10	NUM
bjp-59809	88	14	min	min	NOUN
bjp-59809	88	15	at	at	ADP
bjp-59809	88	16	room	room	NOUN
bjp-59809	88	17	temperature	temperature	NOUN
bjp-59809	88	18	.	.	PUNCT
bjp-59809	89	1	after	after	ADP
bjp-59809	89	2	incubation	incubation	NOUN
bjp-59809	89	3	,	,	PUNCT
bjp-59809	89	4	the	the	DET
bjp-59809	89	5	tubes	tube	NOUN
bjp-59809	89	6	were	be	AUX
bjp-59809	89	7	centrifuged	centrifuge	VERB
bjp-59809	89	8	at	at	ADP
bjp-59809	89	9	12000	12000	NUM
bjp-59809	89	10	x	x	SYM
bjp-59809	89	11	g	g	NOUN
bjp-59809	89	12	for	for	ADP
bjp-59809	89	13	15	15	NUM
bjp-59809	89	14	min	min	NOUN
bjp-59809	89	15	,	,	PUNCT
bjp-59809	89	16	then	then	ADV
bjp-59809	89	17	the	the	DET
bjp-59809	89	18	supernatant	supernatant	NOUN
bjp-59809	89	19	was	be	AUX
bjp-59809	89	20	removed	remove	VERB
bjp-59809	89	21	and	and	CCONJ
bjp-59809	89	22	1	1	NUM
bjp-59809	89	23	ml	ml	NOUN
bjp-59809	89	24	of	of	ADP
bjp-59809	89	25	70%ethanol	70%ethanol	NOUN
bjp-59809	89	26	was	be	AUX
bjp-59809	89	27	added	add	VERB
bjp-59809	89	28	to	to	ADP
bjp-59809	89	29	the	the	DET
bjp-59809	89	30	pellet	pellet	NOUN
bjp-59809	89	31	.	.	PUNCT
bjp-59809	90	1	after	after	ADP
bjp-59809	90	2	repeated	repeat	VERB
bjp-59809	90	3	centrifugation	centrifugation	NOUN
bjp-59809	90	4	at	at	ADP
bjp-59809	90	5	7,000	7,000	NUM
bjp-59809	90	6	g	g	NOUN
bjp-59809	90	7	for	for	ADP
bjp-59809	90	8	10	10	NUM
bjp-59809	90	9	min	min	NOUN
bjp-59809	90	10	,	,	PUNCT
bjp-59809	90	11	the	the	DET
bjp-59809	90	12	supernatant	supernatant	NOUN
bjp-59809	90	13	was	be	AUX
bjp-59809	90	14	removed	remove	VERB
bjp-59809	90	15	and	and	CCONJ
bjp-59809	90	16	the	the	DET
bjp-59809	90	17	pellet	pellet	NOUN
bjp-59809	90	18	was	be	AUX
bjp-59809	90	19	left	leave	VERB
bjp-59809	90	20	to	to	PART
bjp-59809	90	21	dry	dry	VERB
bjp-59809	90	22	.	.	PUNCT
bjp-59809	91	1	after	after	ADP
bjp-59809	91	2	drying	dry	VERB
bjp-59809	91	3	,	,	PUNCT
bjp-59809	91	4	the	the	DET
bjp-59809	91	5	pellet	pellet	NOUN
bjp-59809	91	6	was	be	AUX
bjp-59809	91	7	dissolved	dissolve	VERB
bjp-59809	91	8	with	with	ADP
bjp-59809	91	9	30	30	NUM
bjp-59809	91	10	μl	μl	NOUN
bjp-59809	91	11	of	of	ADP
bjp-59809	91	12	nuclease	nuclease	NOUN
bjp-59809	91	13	-	-	PUNCT
bjp-59809	91	14	free	free	ADJ
bjp-59809	91	15	dh2o	dh2o	NOUN
bjp-59809	91	16	.	.	PUNCT
bjp-59809	92	1	in	in	ADP
bjp-59809	92	2	order	order	NOUN
bjp-59809	92	3	to	to	PART
bjp-59809	92	4	determine	determine	VERB
bjp-59809	92	5	the	the	DET
bjp-59809	92	6	quantity	quantity	NOUN
bjp-59809	92	7	and	and	CCONJ
bjp-59809	92	8	quality	quality	NOUN
bjp-59809	92	9	of	of	ADP
bjp-59809	92	10	the	the	DET
bjp-59809	92	11	isolated	isolate	VERB
bjp-59809	92	12	rnas	rna	NOUN
bjp-59809	92	13	,	,	PUNCT
bjp-59809	92	14	1	1	NUM
bjp-59809	92	15	μl	μl	ADP
bjp-59809	92	16	of	of	ADP
bjp-59809	92	17	each	each	DET
bjp-59809	92	18	rna	rna	NOUN
bjp-59809	92	19	sample	sample	NOUN
bjp-59809	92	20	was	be	AUX
bjp-59809	92	21	taken	take	VERB
bjp-59809	92	22	and	and	CCONJ
bjp-59809	92	23	measurements	measurement	NOUN
bjp-59809	92	24	were	be	AUX
bjp-59809	92	25	made	make	VERB
bjp-59809	92	26	in	in	ADP
bjp-59809	92	27	a	a	DET
bjp-59809	92	28	nanodrop	nanodrop	NOUN
bjp-59809	92	29	(	(	PUNCT
bjp-59809	92	30	maestrogen	maestrogen	PROPN
bjp-59809	92	31	)	)	PUNCT
bjp-59809	92	32	.	.	PUNCT
bjp-59809	93	1	rna	rna	NOUN
bjp-59809	93	2	samples	sample	NOUN
bjp-59809	93	3	with	with	ADP
bjp-59809	93	4	uv	uv	NOUN
bjp-59809	93	5	measurements	measurement	NOUN
bjp-59809	93	6	between	between	ADP
bjp-59809	93	7	2	2	NUM
bjp-59809	93	8	±	±	NUM
bjp-59809	93	9	0.1	0.1	NUM
bjp-59809	93	10	for	for	ADP
bjp-59809	93	11	a260	a260	PROPN
bjp-59809	93	12	/	/	SYM
bjp-59809	93	13	a280	a280	PROPN
bjp-59809	93	14	and	and	CCONJ
bjp-59809	93	15	2.0	2.0	NUM
bjp-59809	93	16	-	-	SYM
bjp-59809	93	17	2.4	2.4	NUM
bjp-59809	93	18	for	for	ADP
bjp-59809	93	19	a260	a260	PROPN
bjp-59809	93	20	/	/	SYM
bjp-59809	93	21	a230	a230	PROPN
bjp-59809	93	22	were	be	AUX
bjp-59809	93	23	used	use	VERB
bjp-59809	93	24	in	in	ADP
bjp-59809	93	25	the	the	DET
bjp-59809	93	26	analyses	analysis	NOUN
bjp-59809	93	27	.	.	PUNCT
bjp-59809	94	1	step	step	NOUN
bjp-59809	94	2	2	2	NUM
bjp-59809	94	3	:	:	PUNCT
bjp-59809	94	4	treatment	treatment	NOUN
bjp-59809	94	5	with	with	ADP
bjp-59809	94	6	dnase	dnase	NOUN
bjp-59809	94	7	i	i	PRON
bjp-59809	94	8	in	in	ADP
bjp-59809	94	9	order	order	NOUN
bjp-59809	94	10	to	to	PART
bjp-59809	94	11	eliminate	eliminate	VERB
bjp-59809	94	12	possible	possible	ADJ
bjp-59809	94	13	genomic	genomic	ADJ
bjp-59809	94	14	dna	dna	NOUN
bjp-59809	94	15	contamination	contamination	NOUN
bjp-59809	94	16	,	,	PUNCT
bjp-59809	94	17	rna	rna	NOUN
bjp-59809	94	18	samples	sample	NOUN
bjp-59809	94	19	were	be	AUX
bjp-59809	94	20	treated	treat	VERB
bjp-59809	94	21	with	with	ADP
bjp-59809	94	22	dnase	dnase	NOUN
bjp-59809	94	23	-	-	PUNCT
bjp-59809	94	24	i	i	PRON
bjp-59809	94	25	enzyme	enzyme	NOUN
bjp-59809	94	26	before	before	ADP
bjp-59809	94	27	cdna	cdna	PROPN
bjp-59809	94	28	synthesis	synthesis	NOUN
bjp-59809	94	29	.	.	PUNCT
bjp-59809	95	1	for	for	ADP
bjp-59809	95	2	this	this	DET
bjp-59809	95	3	purpose	purpose	NOUN
bjp-59809	95	4	,	,	PUNCT
bjp-59809	95	5	2	2	NUM
bjp-59809	95	6	µl	µl	ADP
bjp-59809	95	7	of	of	ADP
bjp-59809	95	8	1u/µl	1u/µl	NUM
bjp-59809	95	9	dnase	dnase	NOUN
bjp-59809	95	10	-	-	PUNCT
bjp-59809	95	11	i	i	PRON
bjp-59809	95	12	enzyme	enzyme	NOUN
bjp-59809	95	13	and	and	CCONJ
bjp-59809	95	14	2	2	NUM
bjp-59809	95	15	µl	µl	NOUN
bjp-59809	95	16	of	of	ADP
bjp-59809	95	17	10x	10x	NOUN
bjp-59809	95	18	reaction	reaction	NOUN
bjp-59809	95	19	buffer	buffer	NOUN
bjp-59809	95	20	were	be	AUX
bjp-59809	95	21	added	add	VERB
bjp-59809	95	22	to	to	ADP
bjp-59809	95	23	2	2	NUM
bjp-59809	95	24	µg	µg	ADV
bjp-59809	95	25	rna	rna	NOUN
bjp-59809	95	26	sample	sample	NOUN
bjp-59809	95	27	and	and	CCONJ
bjp-59809	95	28	the	the	DET
bjp-59809	95	29	total	total	ADJ
bjp-59809	95	30	volume	volume	NOUN
bjp-59809	95	31	was	be	AUX
bjp-59809	95	32	made	make	VERB
bjp-59809	95	33	up	up	ADP
bjp-59809	95	34	to	to	PART
bjp-59809	95	35	18	18	NUM
bjp-59809	95	36	µl	µl	NOUN
bjp-59809	95	37	with	with	ADP
bjp-59809	95	38	nuclease	nuclease	NOUN
bjp-59809	95	39	-	-	PUNCT
bjp-59809	95	40	free	free	ADJ
bjp-59809	95	41	dh2o	dh2o	NOUN
bjp-59809	95	42	.	.	PUNCT
bjp-59809	96	1	after	after	ADP
bjp-59809	96	2	incubation	incubation	NOUN
bjp-59809	96	3	at	at	ADP
bjp-59809	96	4	37	37	NUM
bjp-59809	96	5	°	°	ADP
bjp-59809	96	6	c	c	NOUN
bjp-59809	96	7	for	for	ADP
bjp-59809	96	8	30	30	NUM
bjp-59809	96	9	min	min	NOUN
bjp-59809	96	10	,	,	PUNCT
bjp-59809	96	11	2	2	NUM
bjp-59809	96	12	µl	µl	ADP
bjp-59809	96	13	of	of	ADP
bjp-59809	96	14	50	50	NUM
bjp-59809	96	15	mm	mm	NOUN
bjp-59809	96	16	edta	edta	NOUN
bjp-59809	96	17	was	be	AUX
bjp-59809	96	18	added	add	VERB
bjp-59809	96	19	to	to	ADP
bjp-59809	96	20	the	the	DET
bjp-59809	96	21	samples	sample	NOUN
bjp-59809	96	22	and	and	CCONJ
bjp-59809	96	23	the	the	DET
bjp-59809	96	24	reaction	reaction	NOUN
bjp-59809	96	25	was	be	AUX
bjp-59809	96	26	stopped	stop	VERB
bjp-59809	96	27	by	by	ADP
bjp-59809	96	28	incubation	incubation	NOUN
bjp-59809	96	29	at	at	ADP
bjp-59809	96	30	65	65	NUM
bjp-59809	96	31	°	°	ADP
bjp-59809	96	32	c	c	NOUN
bjp-59809	96	33	for	for	ADP
bjp-59809	96	34	10	10	NUM
bjp-59809	96	35	min	min	NOUN
bjp-59809	96	36	.	.	PROPN
bjp-59809	96	37	step	step	NOUN
bjp-59809	96	38	3	3	NUM
bjp-59809	96	39	:	:	PUNCT
bjp-59809	96	40	cdna	cdna	PROPN
bjp-59809	96	41	synthesis	synthesis	NOUN
bjp-59809	96	42	for	for	ADP
bjp-59809	96	43	cdna	cdna	PROPN
bjp-59809	96	44	synthesis	synthesis	NOUN
bjp-59809	96	45	,	,	PUNCT
bjp-59809	96	46	4	4	NUM
bjp-59809	96	47	µl	µl	NOUN
bjp-59809	96	48	of	of	ADP
bjp-59809	96	49	the	the	DET
bjp-59809	96	50	reaction	reaction	NOUN
bjp-59809	96	51	mixture	mixture	NOUN
bjp-59809	96	52	included	include	VERB
bjp-59809	96	53	in	in	ADP
bjp-59809	96	54	the	the	DET
bjp-59809	96	55	kit	kit	NOUN
bjp-59809	96	56	and	and	CCONJ
bjp-59809	96	57	1	1	NUM
bjp-59809	96	58	µl	µl	NOUN
bjp-59809	96	59	of	of	ADP
bjp-59809	96	60	reverse	reverse	ADJ
bjp-59809	96	61	transcriptase	transcriptase	NOUN
bjp-59809	96	62	enzyme	enzyme	NOUN
bjp-59809	96	63	were	be	AUX
bjp-59809	96	64	added	add	VERB
bjp-59809	96	65	to	to	ADP
bjp-59809	96	66	1	1	NUM
bjp-59809	96	67	µg	µg	ADP
bjp-59809	96	68	total	total	ADJ
bjp-59809	96	69	rna	rna	NOUN
bjp-59809	96	70	,	,	PUNCT
bjp-59809	96	71	and	and	CCONJ
bjp-59809	96	72	the	the	DET
bjp-59809	96	73	volume	volume	NOUN
bjp-59809	96	74	of	of	ADP
bjp-59809	96	75	the	the	DET
bjp-59809	96	76	mixture	mixture	NOUN
bjp-59809	96	77	was	be	AUX
bjp-59809	96	78	made	make	VERB
bjp-59809	96	79	up	up	ADP
bjp-59809	96	80	to	to	PART
bjp-59809	96	81	20	20	NUM
bjp-59809	96	82	µl	µl	NOUN
bjp-59809	96	83	with	with	ADP
bjp-59809	96	84	nuclease	nuclease	NOUN
bjp-59809	96	85	-	-	PUNCT
bjp-59809	96	86	free	free	ADJ
bjp-59809	96	87	water	water	NOUN
bjp-59809	96	88	.	.	PUNCT
bjp-59809	97	1	then	then	ADV
bjp-59809	97	2	,	,	PUNCT
bjp-59809	97	3	cdna	cdna	PROPN
bjp-59809	97	4	synthesis	synthesis	NOUN
bjp-59809	97	5	protocol	protocol	NOUN
bjp-59809	97	6	was	be	AUX
bjp-59809	97	7	applied	apply	VERB
bjp-59809	97	8	as	as	ADP
bjp-59809	97	9	5	5	NUM
bjp-59809	97	10	min	min	NOUN
bjp-59809	97	11	at	at	ADP
bjp-59809	97	12	25ºc	25ºc	NOUN
bjp-59809	97	13	,	,	PUNCT
bjp-59809	97	14	20	20	NUM
bjp-59809	97	15	min	min	NOUN
bjp-59809	97	16	at	at	ADP
bjp-59809	97	17	46ºc	46ºc	ADJ
bjp-59809	97	18	and	and	CCONJ
bjp-59809	97	19	1	1	NUM
bjp-59809	97	20	min	min	NOUN
bjp-59809	97	21	at	at	ADP
bjp-59809	97	22	95ºc	95ºc	NOUN
bjp-59809	97	23	.	.	PUNCT
bjp-59809	98	1	step	step	NOUN
bjp-59809	98	2	4	4	NUM
bjp-59809	98	3	:	:	PUNCT
bjp-59809	98	4	qrt	qrt	ADJ
bjp-59809	98	5	-	-	PUNCT
bjp-59809	98	6	pcr	pcr	ADJ
bjp-59809	98	7	qrt	qrt	ADJ
bjp-59809	98	8	-	-	PUNCT
bjp-59809	98	9	pcr	pcr	ADJ
bjp-59809	98	10	analysis	analysis	NOUN
bjp-59809	98	11	was	be	AUX
bjp-59809	98	12	performed	perform	VERB
bjp-59809	98	13	using	use	VERB
bjp-59809	98	14	qpcr	qpcr	ADJ
bjp-59809	98	15	mastermix	mastermix	NOUN
bjp-59809	98	16	(	(	PUNCT
bjp-59809	98	17	brightgreen	brightgreen	VERB
bjp-59809	98	18	2x	2x	NUM
bjp-59809	98	19	qpcr	qpcr	ADJ
bjp-59809	98	20	mastermix	mastermix	NOUN
bjp-59809	98	21	–	–	PUNCT
bjp-59809	98	22	rox	rox	PROPN
bjp-59809	98	23	,	,	PUNCT
bjp-59809	98	24	abm	abm	PROPN
bjp-59809	98	25	,	,	PUNCT
bjp-59809	98	26	mastermixr	mastermixr	PROPN
bjp-59809	98	27	)	)	PUNCT
bjp-59809	98	28	,	,	PUNCT
bjp-59809	98	29	which	which	PRON
bjp-59809	98	30	can	can	AUX
bjp-59809	98	31	bind	bind	VERB
bjp-59809	98	32	to	to	ADP
bjp-59809	98	33	double	double	ADV
bjp-59809	98	34	-	-	PUNCT
bjp-59809	98	35	stranded	strand	VERB
bjp-59809	98	36	dna	dna	NOUN
bjp-59809	98	37	.	.	PUNCT
bjp-59809	99	1	for	for	ADP
bjp-59809	99	2	this	this	DET
bjp-59809	99	3	purpose	purpose	NOUN
bjp-59809	99	4	,	,	PUNCT
bjp-59809	99	5	reaction	reaction	NOUN
bjp-59809	99	6	mixtures	mixture	NOUN
bjp-59809	99	7	containing	contain	VERB
bjp-59809	99	8	5	5	NUM
bjp-59809	99	9	µl	µl	PART
bjp-59809	99	10	brightgreen	brightgreen	VERB
bjp-59809	99	11	2x	2x	NUM
bjp-59809	99	12	qpcr	qpcr	ADJ
bjp-59809	99	13	mastermix	mastermix	NOUN
bjp-59809	99	14	,	,	PUNCT
bjp-59809	99	15	5	5	NUM
bjp-59809	99	16	pmol	pmol	VERB
bjp-59809	99	17	forward	forward	ADJ
bjp-59809	99	18	primer	primer	NOUN
bjp-59809	99	19	,	,	PUNCT
bjp-59809	99	20	5	5	NUM
bjp-59809	99	21	pmol	pmol	PRON
bjp-59809	99	22	reverse	reverse	ADJ
bjp-59809	99	23	primer	primer	NOUN
bjp-59809	99	24	and	and	CCONJ
bjp-59809	99	25	2	2	NUM
bjp-59809	99	26	µl	µl	ADP
bjp-59809	99	27	cdna	cdna	PROPN
bjp-59809	99	28	were	be	AUX
bjp-59809	99	29	prepared	prepare	VERB
bjp-59809	99	30	.	.	PUNCT
bjp-59809	100	1	the	the	DET
bjp-59809	100	2	reaction	reaction	NOUN
bjp-59809	100	3	was	be	AUX
bjp-59809	100	4	carried	carry	VERB
bjp-59809	100	5	out	out	ADP
bjp-59809	100	6	in	in	ADP
bjp-59809	100	7	a	a	DET
bjp-59809	100	8	real	real	ADJ
bjp-59809	100	9	-	-	PUNCT
bjp-59809	100	10	time	time	NOUN
bjp-59809	100	11	pcr	pcr	NOUN
bjp-59809	100	12	system	system	NOUN
bjp-59809	100	13	(	(	PUNCT
bjp-59809	100	14	bio	bio	NOUN
bjp-59809	100	15	-	-	PROPN
bjp-59809	100	16	rad	rad	PROPN
bjp-59809	100	17	,	,	PUNCT
bjp-59809	100	18	cfx	cfx	PROPN
bjp-59809	100	19	connect	connect	PROPN
bjp-59809	100	20	)	)	PUNCT
bjp-59809	100	21	in	in	ADP
bjp-59809	100	22	40	40	NUM
bjp-59809	100	23	cycles	cycle	NOUN
bjp-59809	100	24	using	use	VERB
bjp-59809	100	25	the	the	DET
bjp-59809	100	26	pcr	pcr	ADJ
bjp-59809	100	27	protocol	protocol	NOUN
bjp-59809	100	28	consisting	consist	VERB
bjp-59809	100	29	of	of	ADP
bjp-59809	100	30	10	10	NUM
bjp-59809	100	31	min	min	NOUN
bjp-59809	100	32	at	at	ADP
bjp-59809	100	33	95ºc	95ºc	ADJ
bjp-59809	100	34	,	,	PUNCT
bjp-59809	100	35	15	15	NUM
bjp-59809	100	36	sec	sec	PROPN
bjp-59809	100	37	at	at	ADP
bjp-59809	100	38	95ºc	95ºc	ADJ
bjp-59809	100	39	and	and	CCONJ
bjp-59809	100	40	60	60	NUM
bjp-59809	100	41	sec	sec	PROPN
bjp-59809	100	42	at	at	ADP
bjp-59809	100	43	60ºc	60ºc	NOUN
bjp-59809	100	44	.	.	PUNCT
bjp-59809	101	1	ct	ct	NUM
bjp-59809	101	2	values	value	NOUN
bjp-59809	101	3	of	of	ADP
bjp-59809	101	4	each	each	DET
bjp-59809	101	5	reaction	reaction	NOUN
bjp-59809	101	6	were	be	AUX
bjp-59809	101	7	used	use	VERB
bjp-59809	101	8	for	for	ADP
bjp-59809	101	9	the	the	DET
bjp-59809	101	10	analysis	analysis	NOUN
bjp-59809	101	11	.	.	PUNCT
bjp-59809	102	1	gapdh	gapdh	NOUN
bjp-59809	102	2	and	and	CCONJ
bjp-59809	102	3	actb	actb	NOUN
bjp-59809	102	4	was	be	AUX
bjp-59809	102	5	used	use	VERB
bjp-59809	102	6	as	as	ADP
bjp-59809	102	7	a	a	DET
bjp-59809	102	8	reference	reference	NOUN
bjp-59809	102	9	gene	gene	NOUN
bjp-59809	102	10	for	for	ADP
bjp-59809	102	11	normalization	normalization	NOUN
bjp-59809	102	12	and	and	CCONJ
bjp-59809	102	13	2	2	NUM
bjp-59809	102	14	–	–	PUNCT
bjp-59809	102	15	δδct	δδct	NOUN
bjp-59809	102	16	was	be	AUX
bjp-59809	102	17	used	use	VERB
bjp-59809	102	18	to	to	PART
bjp-59809	102	19	analyze	analyze	VERB
bjp-59809	102	20	the	the	DET
bjp-59809	102	21	relative	relative	ADJ
bjp-59809	102	22	changes	change	NOUN
bjp-59809	102	23	in	in	ADP
bjp-59809	102	24	gene	gene	NOUN
bjp-59809	102	25	expressions	expression	NOUN
bjp-59809	102	26	.	.	PUNCT
bjp-59809	103	1	references	reference	NOUN
bjp-59809	103	2	çınar	çınar	VERB
bjp-59809	103	3	et	et	PROPN
bjp-59809	103	4	al	al	PROPN
bjp-59809	103	5	.	.	PROPN
bjp-59809	103	6	,	,	PUNCT
bjp-59809	103	7	2021a	2021a	NUM
bjp-59809	103	8	;	;	PUNCT
bjp-59809	103	9	çınar	çınar	PROPN
bjp-59809	103	10	et	et	PROPN
bjp-59809	103	11	al	al	PROPN
bjp-59809	103	12	.	.	PROPN
bjp-59809	103	13	,	,	PUNCT
bjp-59809	103	14	2021b	2021b	NUM
bjp-59809	103	15	;	;	PUNCT
bjp-59809	103	16	güçlü	güçlü	NOUN
bjp-59809	103	17	et	et	PROPN
bjp-59809	103	18	al	al	PROPN
bjp-59809	103	19	.	.	PROPN
bjp-59809	103	20	,	,	PUNCT
bjp-59809	103	21	2021	2021	NUM
bjp-59809	103	22	44	44	NUM
bjp-59809	103	23	bangladesh	bangladesh	NOUN
bjp-59809	103	24	j	j	PROPN
bjp-59809	103	25	pharmacol	pharmacol	PROPN
bjp-59809	103	26	2022	2022	NUM
bjp-59809	103	27	;	;	PUNCT
bjp-59809	103	28	17	17	NUM
bjp-59809	103	29	:	:	SYM
bjp-59809	103	30	42	42	NUM
bjp-59809	103	31	-	-	SYM
bjp-59809	103	32	50	50	NUM
bjp-59809	103	33	evaluated	evaluate	VERB
bjp-59809	103	34	with	with	ADP
bjp-59809	103	35	student	student	NOUN
bjp-59809	103	36	’s	’s	PART
bjp-59809	103	37	t	t	PROPN
bjp-59809	103	38	test	test	NOUN
bjp-59809	103	39	and	and	CCONJ
bjp-59809	103	40	one	one	NUM
bjp-59809	103	41	-	-	PUNCT
bjp-59809	103	42	way	way	NOUN
bjp-59809	103	43	anova	anova	PROPN
bjp-59809	103	44	.	.	PUNCT
bjp-59809	104	1	ic50	ic50	PROPN
bjp-59809	104	2	value	value	NOUN
bjp-59809	104	3	was	be	AUX
bjp-59809	104	4	calculated	calculate	VERB
bjp-59809	104	5	using	use	VERB
bjp-59809	104	6	graphpad	graphpad	NOUN
bjp-59809	104	7	prism	prism	NOUN
bjp-59809	104	8	8.0.2	8.0.2	NUM
bjp-59809	104	9	version	version	NOUN
bjp-59809	104	10	.	.	PUNCT
bjp-59809	105	1	also	also	ADV
bjp-59809	105	2	,	,	PUNCT
bjp-59809	105	3	all	all	DET
bjp-59809	105	4	statistical	statistical	ADJ
bjp-59809	105	5	analysis	analysis	NOUN
bjp-59809	105	6	and	and	CCONJ
bjp-59809	105	7	bar	bar	NOUN
bjp-59809	105	8	graphs	graph	NOUN
bjp-59809	105	9	were	be	AUX
bjp-59809	105	10	performed	perform	VERB
bjp-59809	105	11	with	with	ADP
bjp-59809	105	12	graphpad	graphpad	NOUN
bjp-59809	105	13	prism	prism	NOUN
bjp-59809	105	14	8.0.2	8.0.2	NUM
bjp-59809	105	15	version	version	NOUN
bjp-59809	105	16	.	.	PUNCT
bjp-59809	106	1	rt2	rt2	PROPN
bjp-59809	106	2	profiler	profiler	NOUN
bjp-59809	106	3	™	™	ADJ
bjp-59809	106	4	pcr	pcr	NOUN
bjp-59809	106	5	array	array	NOUN
bjp-59809	106	6	data	datum	NOUN
bjp-59809	106	7	analysis	analysis	NOUN
bjp-59809	106	8	program	program	NOUN
bjp-59809	106	9	was	be	AUX
bjp-59809	106	10	used	use	VERB
bjp-59809	106	11	for	for	ADP
bjp-59809	106	12	statistical	statistical	ADJ
bjp-59809	106	13	determination	determination	NOUN
bjp-59809	106	14	of	of	ADP
bjp-59809	106	15	changes	change	NOUN
bjp-59809	106	16	in	in	ADP
bjp-59809	106	17	mrna	mrna	PROPN
bjp-59809	106	18	expression	expression	NOUN
bjp-59809	106	19	level	level	NOUN
bjp-59809	106	20	.	.	PUNCT
bjp-59809	107	1	p<0.05	p<0.05	NOUN
bjp-59809	107	2	value	value	NOUN
bjp-59809	107	3	was	be	AUX
bjp-59809	107	4	considered	consider	VERB
bjp-59809	107	5	statistically	statistically	ADV
bjp-59809	107	6	significant	significant	ADJ
bjp-59809	107	7	.	.	PUNCT
bjp-59809	108	1	results	result	VERB
bjp-59809	108	2	u87	u87	ADJ
bjp-59809	108	3	glioblastoma	glioblastoma	NOUN
bjp-59809	108	4	multiforme	multiforme	NOUN
bjp-59809	108	5	cell	cell	NOUN
bjp-59809	108	6	proliferation	proliferation	NOUN
bjp-59809	108	7	and	and	CCONJ
bjp-59809	108	8	colony	colony	NOUN
bjp-59809	108	9	formation	formation	NOUN
bjp-59809	108	10	xtt	xtt	NOUN
bjp-59809	108	11	cell	cell	NOUN
bjp-59809	108	12	viability	viability	NOUN
bjp-59809	108	13	assay	assay	NOUN
bjp-59809	108	14	was	be	AUX
bjp-59809	108	15	used	use	VERB
bjp-59809	108	16	to	to	PART
bjp-59809	108	17	determine	determine	VERB
bjp-59809	108	18	whether	whether	SCONJ
bjp-59809	108	19	ak-7	ak-7	CCONJ
bjp-59809	108	20	affects	affect	VERB
bjp-59809	108	21	u87	u87	ADJ
bjp-59809	108	22	cell	cell	NOUN
bjp-59809	108	23	proliferation	proliferation	NOUN
bjp-59809	108	24	.	.	PUNCT
bjp-59809	109	1	u87	u87	ADJ
bjp-59809	109	2	cells	cell	NOUN
bjp-59809	109	3	were	be	AUX
bjp-59809	109	4	exposed	expose	VERB
bjp-59809	109	5	to	to	ADP
bjp-59809	109	6	various	various	ADJ
bjp-59809	109	7	concentrations	concentration	NOUN
bjp-59809	109	8	of	of	ADP
bjp-59809	109	9	ak-7	ak-7	PROPN
bjp-59809	109	10	.	.	PUNCT
bjp-59809	110	1	it	it	PRON
bjp-59809	110	2	was	be	AUX
bjp-59809	110	3	determined	determine	VERB
bjp-59809	110	4	that	that	SCONJ
bjp-59809	110	5	ak-7	ak-7	CCONJ
bjp-59809	110	6	inhibited	inhibited	ADJ
bjp-59809	110	7	cell	cell	NOUN
bjp-59809	110	8	proliferation	proliferation	NOUN
bjp-59809	110	9	in	in	ADP
bjp-59809	110	10	a	a	DET
bjp-59809	110	11	dose	dose	NOUN
bjp-59809	110	12	and	and	CCONJ
bjp-59809	110	13	time	time	NOUN
bjp-59809	110	14	-	-	PUNCT
bjp-59809	110	15	dependent	dependent	ADJ
bjp-59809	110	16	manner	manner	NOUN
bjp-59809	110	17	(	(	PUNCT
bjp-59809	110	18	figure	figure	NOUN
bjp-59809	110	19	1a	1a	NOUN
bjp-59809	110	20	)	)	PUNCT
bjp-59809	110	21	.	.	PUNCT
bjp-59809	111	1	the	the	DET
bjp-59809	111	2	ic50	ic50	PROPN
bjp-59809	111	3	value	value	NOUN
bjp-59809	111	4	of	of	ADP
bjp-59809	111	5	ak-7	ak-7	CCONJ
bjp-59809	111	6	induced	induced	ADJ
bjp-59809	111	7	inhibition	inhibition	NOUN
bjp-59809	111	8	at	at	ADP
bjp-59809	111	9	various	various	ADJ
bjp-59809	111	10	concentrations	concentration	NOUN
bjp-59809	111	11	at	at	ADP
bjp-59809	111	12	48	48	NUM
bjp-59809	111	13	hours	hour	NOUN
bjp-59809	111	14	was	be	AUX
bjp-59809	111	15	identified	identify	VERB
bjp-59809	111	16	as	as	ADP
bjp-59809	111	17	107.0	107.0	NUM
bjp-59809	111	18	µm	µm	NOUN
bjp-59809	111	19	in	in	ADP
bjp-59809	111	20	u87	u87	ADJ
bjp-59809	111	21	cell	cell	NOUN
bjp-59809	111	22	.	.	PUNCT
bjp-59809	112	1	the	the	DET
bjp-59809	112	2	effects	effect	NOUN
bjp-59809	112	3	of	of	ADP
bjp-59809	112	4	75	75	NUM
bjp-59809	112	5	and	and	CCONJ
bjp-59809	112	6	100	100	NUM
bjp-59809	112	7	µm	µm	ADP
bjp-59809	112	8	doses	dose	NOUN
bjp-59809	112	9	of	of	ADP
bjp-59809	112	10	ak-7	ak-7	ADP
bjp-59809	112	11	on	on	ADP
bjp-59809	112	12	the	the	DET
bjp-59809	112	13	colony	colony	NOUN
bjp-59809	112	14	forming	form	VERB
bjp-59809	112	15	capacity	capacity	NOUN
bjp-59809	112	16	on	on	ADP
bjp-59809	112	17	u87	u87	ADJ
bjp-59809	112	18	cells	cell	NOUN
bjp-59809	112	19	were	be	AUX
bjp-59809	112	20	evaluated	evaluate	VERB
bjp-59809	112	21	according	accord	VERB
bjp-59809	112	22	to	to	ADP
bjp-59809	112	23	control	control	PROPN
bjp-59809	112	24	group	group	NOUN
bjp-59809	112	25	(	(	PUNCT
bjp-59809	112	26	untreated	untreated	ADJ
bjp-59809	112	27	cells	cell	NOUN
bjp-59809	112	28	with	with	ADP
bjp-59809	112	29	ak-7	ak-7	NOUN
bjp-59809	112	30	)	)	PUNCT
bjp-59809	112	31	.	.	PUNCT
bjp-59809	113	1	similarly	similarly	ADV
bjp-59809	113	2	,	,	PUNCT
bjp-59809	113	3	it	it	PRON
bjp-59809	113	4	was	be	AUX
bjp-59809	113	5	found	find	VERB
bjp-59809	113	6	that	that	SCONJ
bjp-59809	113	7	colony	colony	NOUN
bjp-59809	113	8	formation	formation	NOUN
bjp-59809	113	9	significantly	significantly	ADV
bjp-59809	113	10	decreased	decrease	VERB
bjp-59809	113	11	by	by	ADP
bjp-59809	113	12	treatment	treatment	NOUN
bjp-59809	113	13	75	75	NUM
bjp-59809	113	14	and	and	CCONJ
bjp-59809	113	15	100	100	NUM
bjp-59809	113	16	μm	μm	NUM
bjp-59809	113	17	doses	dose	NOUN
bjp-59809	113	18	of	of	ADP
bjp-59809	113	19	ak-7	ak-7	ADP
bjp-59809	113	20	comparison	comparison	NOUN
bjp-59809	113	21	to	to	ADP
bjp-59809	113	22	the	the	DET
bjp-59809	113	23	control	control	NOUN
bjp-59809	113	24	group	group	NOUN
bjp-59809	113	25	on	on	ADP
bjp-59809	113	26	u87	u87	ADJ
bjp-59809	113	27	cells	cell	NOUN
bjp-59809	113	28	.	.	PUNCT
bjp-59809	114	1	however	however	ADV
bjp-59809	114	2	,	,	PUNCT
bjp-59809	114	3	there	there	PRON
bjp-59809	114	4	was	be	VERB
bjp-59809	114	5	no	no	DET
bjp-59809	114	6	significant	significant	ADJ
bjp-59809	114	7	difference	difference	NOUN
bjp-59809	114	8	in	in	ADP
bjp-59809	114	9	colony	colony	NOUN
bjp-59809	114	10	formation	formation	NOUN
bjp-59809	114	11	ability	ability	NOUN
bjp-59809	114	12	between	between	ADP
bjp-59809	114	13	75	75	NUM
bjp-59809	114	14	and	and	CCONJ
bjp-59809	114	15	100	100	NUM
bjp-59809	114	16	µm	µm	ADP
bjp-59809	114	17	dose	dose	NOUN
bjp-59809	114	18	groups	group	NOUN
bjp-59809	114	19	(	(	PUNCT
bjp-59809	114	20	figure	figure	NOUN
bjp-59809	114	21	1bc	1bc	ADJ
bjp-59809	114	22	)	)	PUNCT
bjp-59809	114	23	.	.	PUNCT
bjp-59809	115	1	apoptosis	apoptosis	NOUN
bjp-59809	115	2	of	of	ADP
bjp-59809	115	3	u87	u87	ADJ
bjp-59809	115	4	glioblastoma	glioblastoma	NOUN
bjp-59809	115	5	multiforme	multiforme	NOUN
bjp-59809	115	6	cells	cell	NOUN
bjp-59809	115	7	to	to	PART
bjp-59809	115	8	evaluate	evaluate	VERB
bjp-59809	115	9	whether	whether	SCONJ
bjp-59809	115	10	the	the	DET
bjp-59809	115	11	inhibition	inhibition	NOUN
bjp-59809	115	12	mechanism	mechanism	NOUN
bjp-59809	115	13	of	of	ADP
bjp-59809	115	14	ak-7	ak-7	ADP
bjp-59809	115	15	on	on	ADP
bjp-59809	115	16	the	the	DET
bjp-59809	115	17	u87	u87	ADJ
bjp-59809	115	18	glioblastoma	glioblastoma	NOUN
bjp-59809	115	19	multiforme	multiforme	NOUN
bjp-59809	115	20	cells	cell	NOUN
bjp-59809	115	21	is	be	AUX
bjp-59809	115	22	apoptosismediated	apoptosismediate	VERB
bjp-59809	115	23	,	,	PUNCT
bjp-59809	115	24	we	we	PRON
bjp-59809	115	25	first	first	ADV
bjp-59809	115	26	performed	perform	VERB
bjp-59809	115	27	the	the	DET
bjp-59809	115	28	fitc	fitc	NOUN
bjp-59809	115	29	-	-	PUNCT
bjp-59809	115	30	annexin	annexin	PROPN
bjp-59809	115	31	v/7aad	v/7aad	VERB
bjp-59809	115	32	analysis	analysis	NOUN
bjp-59809	115	33	.	.	PUNCT
bjp-59809	116	1	for	for	ADP
bjp-59809	116	2	this	this	DET
bjp-59809	116	3	analysis	analysis	NOUN
bjp-59809	116	4	,	,	PUNCT
bjp-59809	116	5	u87	u87	ADJ
bjp-59809	116	6	cells	cell	NOUN
bjp-59809	116	7	were	be	AUX
bjp-59809	116	8	treated	treat	VERB
bjp-59809	116	9	with	with	ADP
bjp-59809	116	10	75	75	NUM
bjp-59809	116	11	and	and	CCONJ
bjp-59809	116	12	100	100	NUM
bjp-59809	116	13	µm	µm	ADP
bjp-59809	116	14	doses	dose	NOUN
bjp-59809	116	15	of	of	ADP
bjp-59809	116	16	ak-7	ak-7	ADP
bjp-59809	116	17	for	for	ADP
bjp-59809	116	18	48	48	NUM
bjp-59809	116	19	hours	hour	NOUN
bjp-59809	116	20	.	.	PUNCT
bjp-59809	117	1	compared	compare	VERB
bjp-59809	117	2	to	to	ADP
bjp-59809	117	3	the	the	DET
bjp-59809	117	4	control	control	NOUN
bjp-59809	117	5	group	group	NOUN
bjp-59809	117	6	,	,	PUNCT
bjp-59809	117	7	it	it	PRON
bjp-59809	117	8	was	be	AUX
bjp-59809	117	9	determined	determine	VERB
bjp-59809	117	10	that	that	SCONJ
bjp-59809	117	11	cellular	cellular	ADJ
bjp-59809	117	12	apoptosis	apoptosis	NOUN
bjp-59809	117	13	(	(	PUNCT
bjp-59809	117	14	early	early	ADJ
bjp-59809	117	15	and	and	CCONJ
bjp-59809	117	16	late	late	ADJ
bjp-59809	117	17	apoptosis	apoptosis	NOUN
bjp-59809	117	18	)	)	PUNCT
bjp-59809	117	19	rate	rate	NOUN
bjp-59809	117	20	was	be	AUX
bjp-59809	117	21	significantly	significantly	ADV
bjp-59809	117	22	increased	increase	VERB
bjp-59809	117	23	in	in	ADP
bjp-59809	117	24	cells	cell	NOUN
bjp-59809	117	25	treated	treat	VERB
bjp-59809	117	26	with	with	ADP
bjp-59809	117	27	ak-7	ak-7	ADP
bjp-59809	117	28	in	in	ADP
bjp-59809	117	29	a	a	DET
bjp-59809	117	30	dose	dose	NOUN
bjp-59809	117	31	-	-	PUNCT
bjp-59809	117	32	dependent	dependent	ADJ
bjp-59809	117	33	manner	manner	NOUN
bjp-59809	117	34	.	.	PUNCT
bjp-59809	118	1	also	also	ADV
bjp-59809	118	2	,	,	PUNCT
bjp-59809	118	3	a	a	DET
bjp-59809	118	4	significant	significant	ADJ
bjp-59809	118	5	increase	increase	NOUN
bjp-59809	118	6	was	be	AUX
bjp-59809	118	7	observed	observe	VERB
bjp-59809	118	8	in	in	ADP
bjp-59809	118	9	the	the	DET
bjp-59809	118	10	apoptosis	apoptosis	NOUN
bjp-59809	118	11	rate	rate	NOUN
bjp-59809	118	12	between	between	ADP
bjp-59809	118	13	dose	dose	NOUN
bjp-59809	118	14	groups	group	NOUN
bjp-59809	118	15	of	of	ADP
bjp-59809	118	16	ak-7	ak-7	PROPN
bjp-59809	118	17	(	(	PUNCT
bjp-59809	118	18	figure	figure	NOUN
bjp-59809	118	19	2a	2a	NUM
bjp-59809	118	20	-	-	PUNCT
bjp-59809	118	21	b	b	NOUN
bjp-59809	118	22	)	)	PUNCT
bjp-59809	118	23	(	(	PUNCT
bjp-59809	118	24	p<0.05	p<0.05	NOUN
bjp-59809	118	25	)	)	PUNCT
bjp-59809	118	26	.	.	PUNCT
bjp-59809	119	1	the	the	DET
bjp-59809	119	2	degree	degree	NOUN
bjp-59809	119	3	of	of	ADP
bjp-59809	119	4	apoptosis	apoptosis	NOUN
bjp-59809	119	5	was	be	AUX
bjp-59809	119	6	shown	show	VERB
bjp-59809	119	7	as	as	ADP
bjp-59809	119	8	the	the	DET
bjp-59809	119	9	enrichment	enrichment	NOUN
bjp-59809	119	10	factor	factor	NOUN
bjp-59809	119	11	calculated	calculate	VERB
bjp-59809	119	12	as	as	SCONJ
bjp-59809	119	13	follows	follow	VERB
bjp-59809	119	14	at	at	ADP
bjp-59809	119	15	bar	bar	NOUN
bjp-59809	119	16	graph	graph	NOUN
bjp-59809	119	17	:	:	PUNCT
bjp-59809	119	18	enrichment	enrichment	NOUN
bjp-59809	119	19	factor	factor	NOUN
bjp-59809	119	20	=	=	SYM
bjp-59809	119	21	dna	dna	PROPN
bjp-59809	119	22	fragments	fragment	VERB
bjp-59809	119	23	in	in	ADP
bjp-59809	119	24	the	the	DET
bjp-59809	119	25	75	75	NUM
bjp-59809	119	26	and	and	CCONJ
bjp-59809	119	27	100	100	NUM
bjp-59809	119	28	μm	μm	NUM
bjp-59809	119	29	ak-7	ak-7	CCONJ
bjp-59809	119	30	treated	treat	VERB
bjp-59809	119	31	sample	sample	NOUN
bjp-59809	119	32	/	/	SYM
bjp-59809	119	33	dna	dna	NOUN
bjp-59809	119	34	fragments	fragment	NOUN
bjp-59809	119	35	in	in	ADP
bjp-59809	119	36	the	the	DET
bjp-59809	119	37	control	control	NOUN
bjp-59809	119	38	.	.	PUNCT
bjp-59809	120	1	according	accord	VERB
bjp-59809	120	2	to	to	ADP
bjp-59809	120	3	the	the	DET
bjp-59809	120	4	results	result	NOUN
bjp-59809	120	5	of	of	ADP
bjp-59809	120	6	this	this	DET
bjp-59809	120	7	analysis	analysis	NOUN
bjp-59809	120	8	,	,	PUNCT
bjp-59809	120	9	it	it	PRON
bjp-59809	120	10	was	be	AUX
bjp-59809	120	11	found	find	VERB
bjp-59809	120	12	that	that	SCONJ
bjp-59809	120	13	ak-7	ak-7	ADV
bjp-59809	120	14	caused	cause	VERB
bjp-59809	120	15	a	a	DET
bjp-59809	120	16	significant	significant	ADJ
bjp-59809	120	17	increase	increase	NOUN
bjp-59809	120	18	in	in	ADP
bjp-59809	120	19	the	the	DET
bjp-59809	120	20	enrichment	enrichment	NOUN
bjp-59809	120	21	factor	factor	NOUN
bjp-59809	120	22	in	in	ADP
bjp-59809	120	23	a	a	DET
bjp-59809	120	24	dosedependent	dosedependent	NOUN
bjp-59809	120	25	manner	manner	NOUN
bjp-59809	120	26	when	when	SCONJ
bjp-59809	120	27	compared	compare	VERB
bjp-59809	120	28	to	to	ADP
bjp-59809	120	29	the	the	DET
bjp-59809	120	30	control	control	NOUN
bjp-59809	120	31	group	group	NOUN
bjp-59809	120	32	.	.	PUNCT
bjp-59809	121	1	in	in	ADP
bjp-59809	121	2	addition	addition	NOUN
bjp-59809	121	3	,	,	PUNCT
bjp-59809	121	4	a	a	DET
bjp-59809	121	5	similarly	similarly	ADV
bjp-59809	121	6	significant	significant	ADJ
bjp-59809	121	7	difference	difference	NOUN
bjp-59809	121	8	was	be	AUX
bjp-59809	121	9	also	also	ADV
bjp-59809	121	10	determined	determine	VERB
bjp-59809	121	11	between	between	ADP
bjp-59809	121	12	the	the	DET
bjp-59809	121	13	groups	group	NOUN
bjp-59809	121	14	treated	treat	VERB
bjp-59809	121	15	with	with	ADP
bjp-59809	121	16	75	75	NUM
bjp-59809	121	17	and	and	CCONJ
bjp-59809	121	18	100	100	NUM
bjp-59809	121	19	µm	µm	ADP
bjp-59809	121	20	doses	dose	NOUN
bjp-59809	121	21	of	of	ADP
bjp-59809	121	22	ak-7	ak-7	ADP
bjp-59809	121	23	(	(	PUNCT
bjp-59809	121	24	figure	figure	NOUN
bjp-59809	121	25	2c	2c	NUM
bjp-59809	121	26	)	)	PUNCT
bjp-59809	121	27	(	(	PUNCT
bjp-59809	121	28	p<0.05	p<0.05	NOUN
bjp-59809	121	29	)	)	PUNCT
bjp-59809	121	30	.	.	PUNCT
bjp-59809	122	1	it	it	PRON
bjp-59809	123	1	b	b	X
bjp-59809	123	2	c	c	NOUN
bjp-59809	123	3	60	60	NUM
bjp-59809	123	4	0	0	NUM
bjp-59809	123	5	c	c	NOUN
bjp-59809	123	6	e	e	NOUN
bjp-59809	123	7	ll	ll	NOUN
bjp-59809	123	8	v	v	PROPN
bjp-59809	123	9	ia	ia	PROPN
bjp-59809	123	10	b	b	PROPN
bjp-59809	123	11	ili	ili	PROPN
bjp-59809	124	1	ty	ty	INTJ
bjp-59809	124	2	(	(	PUNCT
bjp-59809	124	3	%	%	NOUN
bjp-59809	124	4	)	)	PUNCT
bjp-59809	124	5	40	40	NUM
bjp-59809	124	6	20	20	NUM
bjp-59809	124	7	80	80	NUM
bjp-59809	124	8	control	control	NOUN
bjp-59809	124	9	+	+	X
bjp-59809	125	1	+	+	CCONJ
bjp-59809	126	1	+	+	X
bjp-59809	126	2	ak-7	ak-7	ADJ
bjp-59809	126	3	(	(	PUNCT
bjp-59809	126	4	µm	µm	NOUN
bjp-59809	126	5	)	)	PUNCT
bjp-59809	126	6	5	5	NUM
bjp-59809	126	7	25	25	NUM
bjp-59809	126	8	75	75	NUM
bjp-59809	126	9	125	125	NUM
bjp-59809	126	10	200	200	NUM
bjp-59809	126	11	5	5	NUM
bjp-59809	126	12	25	25	NUM
bjp-59809	126	13	75	75	NUM
bjp-59809	126	14	125	125	NUM
bjp-59809	126	15	200	200	NUM
bjp-59809	126	16	5	5	NUM
bjp-59809	126	17	25	25	NUM
bjp-59809	126	18	75	75	NUM
bjp-59809	126	19	125	125	NUM
bjp-59809	126	20	200	200	NUM
bjp-59809	126	21	ak-7	ak-7	ADP
bjp-59809	126	22	(	(	PUNCT
bjp-59809	126	23	µm	µm	NOUN
bjp-59809	126	24	)	)	PUNCT
bjp-59809	126	25	10	10	NUM
bjp-59809	126	26	50	50	NUM
bjp-59809	126	27	100	100	NUM
bjp-59809	126	28	150	150	NUM
bjp-59809	126	29	250	250	NUM
bjp-59809	126	30	10	10	NUM
bjp-59809	126	31	50	50	NUM
bjp-59809	126	32	100	100	NUM
bjp-59809	126	33	150	150	NUM
bjp-59809	126	34	250	250	NUM
bjp-59809	126	35	10	10	NUM
bjp-59809	126	36	50	50	NUM
bjp-59809	126	37	100	100	NUM
bjp-59809	126	38	150	150	NUM
bjp-59809	126	39	250	250	NUM
bjp-59809	126	40	a	a	DET
bjp-59809	126	41	figure	figure	NOUN
bjp-59809	126	42	1	1	NUM
bjp-59809	126	43	:	:	PUNCT
bjp-59809	126	44	ak-7	ak-7	CCONJ
bjp-59809	126	45	reduced	reduce	VERB
bjp-59809	126	46	the	the	DET
bjp-59809	126	47	survival	survival	NOUN
bjp-59809	126	48	and	and	CCONJ
bjp-59809	126	49	colony	colony	NOUN
bjp-59809	126	50	formation	formation	NOUN
bjp-59809	126	51	of	of	ADP
bjp-59809	126	52	glioblastoma	glioblastoma	NOUN
bjp-59809	126	53	multiforme	multiforme	NOUN
bjp-59809	126	54	cells	cell	NOUN
bjp-59809	126	55	.	.	PUNCT
bjp-59809	127	1	dose(5	dose(5	VERB
bjp-59809	127	2	,	,	PUNCT
bjp-59809	127	3	10	10	NUM
bjp-59809	127	4	,	,	PUNCT
bjp-59809	127	5	25	25	NUM
bjp-59809	127	6	,	,	PUNCT
bjp-59809	127	7	50	50	NUM
bjp-59809	127	8	,	,	PUNCT
bjp-59809	127	9	75	75	NUM
bjp-59809	127	10	,	,	PUNCT
bjp-59809	127	11	100	100	NUM
bjp-59809	127	12	,	,	PUNCT
bjp-59809	127	13	125	125	NUM
bjp-59809	127	14	,	,	PUNCT
bjp-59809	127	15	150	150	NUM
bjp-59809	127	16	,	,	PUNCT
bjp-59809	127	17	200	200	NUM
bjp-59809	127	18	,	,	PUNCT
bjp-59809	127	19	and	and	CCONJ
bjp-59809	127	20	250	250	NUM
bjp-59809	127	21	µm	µm	NOUN
bjp-59809	127	22	)	)	PUNCT
bjp-59809	127	23	and	and	CCONJ
bjp-59809	127	24	time(24	time(24	ADJ
bjp-59809	127	25	,	,	PUNCT
bjp-59809	127	26	48	48	NUM
bjp-59809	127	27	,	,	PUNCT
bjp-59809	127	28	72	72	NUM
bjp-59809	127	29	hours	hour	NOUN
bjp-59809	127	30	)	)	PUNCT
bjp-59809	127	31	dependent	dependent	ADJ
bjp-59809	127	32	effect	effect	NOUN
bjp-59809	127	33	of	of	ADP
bjp-59809	127	34	ak-7	ak-7	ADP
bjp-59809	127	35	on	on	ADP
bjp-59809	127	36	the	the	DET
bjp-59809	127	37	u87	u87	ADJ
bjp-59809	127	38	human	human	ADJ
bjp-59809	127	39	glioblastoma	glioblastoma	NOUN
bjp-59809	127	40	multiforme	multiforme	NOUN
bjp-59809	127	41	cell	cell	NOUN
bjp-59809	127	42	line	line	NOUN
bjp-59809	127	43	(	(	PUNCT
bjp-59809	127	44	a	a	NOUN
bjp-59809	127	45	)	)	PUNCT
bjp-59809	127	46	.	.	PUNCT
bjp-59809	128	1	colony	colony	NOUN
bjp-59809	128	2	formation	formation	NOUN
bjp-59809	128	3	assay	assay	NOUN
bjp-59809	128	4	was	be	AUX
bjp-59809	128	5	performed	perform	VERB
bjp-59809	128	6	to	to	PART
bjp-59809	128	7	analyze	analyze	VERB
bjp-59809	128	8	the	the	DET
bjp-59809	128	9	colony	colony	NOUN
bjp-59809	128	10	forming	form	VERB
bjp-59809	128	11	capacity	capacity	NOUN
bjp-59809	128	12	of	of	ADP
bjp-59809	128	13	u87	u87	ADJ
bjp-59809	128	14	cells	cell	NOUN
bjp-59809	128	15	which	which	PRON
bjp-59809	128	16	were	be	AUX
bjp-59809	128	17	treated	treat	VERB
bjp-59809	128	18	with	with	ADP
bjp-59809	128	19	different	different	ADJ
bjp-59809	128	20	concentrations	concentration	NOUN
bjp-59809	128	21	(	(	PUNCT
bjp-59809	128	22	75	75	NUM
bjp-59809	128	23	and	and	CCONJ
bjp-59809	128	24	100	100	NUM
bjp-59809	128	25	μm	μm	NUM
bjp-59809	128	26	)	)	PUNCT
bjp-59809	128	27	of	of	ADP
bjp-59809	128	28	ak-7	ak-7	PROPN
bjp-59809	128	29	(	(	PUNCT
bjp-59809	128	30	ap<0.05	ap<0.05	NOUN
bjp-59809	128	31	;	;	PUNCT
bjp-59809	128	32	bp<0.01	bp<0.01	PROPN
bjp-59809	128	33	)	)	PUNCT
bjp-59809	128	34	(	(	PUNCT
bjp-59809	128	35	b	b	X
bjp-59809	128	36	-	-	PUNCT
bjp-59809	128	37	c	c	NOUN
bjp-59809	128	38	)	)	PUNCT
bjp-59809	128	39	100	100	NUM
bjp-59809	128	40	120	120	NUM
bjp-59809	128	41	24	24	NUM
bjp-59809	128	42	hours	hour	NOUN
bjp-59809	128	43	48	48	NUM
bjp-59809	128	44	hours	hour	NOUN
bjp-59809	128	45	72	72	NUM
bjp-59809	128	46	hours	hour	NOUN
bjp-59809	128	47	ak-7	ak-7	ADP
bjp-59809	128	48	0	0	NUM
bjp-59809	128	49	75	75	NUM
bjp-59809	128	50	100	100	NUM
bjp-59809	128	51	µm	µm	ADP
bjp-59809	128	52	ak-7	ak-7	ADP
bjp-59809	128	53	0	0	NUM
bjp-59809	128	54	75	75	NUM
bjp-59809	128	55	100	100	NUM
bjp-59809	128	56	µm	µm	ADP
bjp-59809	128	57	0	0	NUM
bjp-59809	128	58	100	100	NUM
bjp-59809	128	59	200	200	NUM
bjp-59809	128	60	300	300	NUM
bjp-59809	128	61	400	400	NUM
bjp-59809	128	62	n	n	NUM
bjp-59809	128	63	u	u	NOUN
bjp-59809	128	64	m	m	NOUN
bjp-59809	128	65	b	b	NOUN
bjp-59809	128	66	e	e	NOUN
bjp-59809	128	67	r	r	NOUN
bjp-59809	128	68	o	o	X
bjp-59809	129	1	f	f	X
bjp-59809	129	2	c	c	NOUN
bjp-59809	129	3	o	o	INTJ
bjp-59809	129	4	lo	lo	INTJ
bjp-59809	130	1	n	n	CCONJ
bjp-59809	130	2	ie	ie	PROPN
bjp-59809	130	3	s	s	VERB
bjp-59809	130	4	a	a	DET
bjp-59809	130	5	b	b	PROPN
bjp-59809	130	6	bangladesh	bangladesh	NOUN
bjp-59809	130	7	j	j	PROPN
bjp-59809	130	8	pharmacol	pharmacol	PROPN
bjp-59809	130	9	2022	2022	NUM
bjp-59809	130	10	;	;	PUNCT
bjp-59809	130	11	17	17	NUM
bjp-59809	130	12	:	:	SYM
bjp-59809	130	13	42	42	NUM
bjp-59809	130	14	-	-	SYM
bjp-59809	130	15	50	50	NUM
bjp-59809	130	16	45	45	NUM
bjp-59809	130	17	was	be	AUX
bjp-59809	130	18	demonstrated	demonstrate	VERB
bjp-59809	130	19	that	that	SCONJ
bjp-59809	130	20	ak-7	ak-7	CCONJ
bjp-59809	130	21	induced	induce	VERB
bjp-59809	130	22	dna	dna	PROPN
bjp-59809	130	23	fragmentation	fragmentation	NOUN
bjp-59809	130	24	.	.	PUNCT
bjp-59809	131	1	apoptosis	apoptosis	NOUN
bjp-59809	131	2	of	of	ADP
bjp-59809	131	3	u87	u87	ADJ
bjp-59809	131	4	glioblastoma	glioblastoma	NOUN
bjp-59809	131	5	multiforme	multiforme	NOUN
bjp-59809	131	6	cells	cell	NOUN
bjp-59809	131	7	through	through	ADP
bjp-59809	131	8	the	the	DET
bjp-59809	131	9	caspase	caspase	NOUN
bjp-59809	131	10	pathway	pathway	NOUN
bjp-59809	131	11	to	to	PART
bjp-59809	131	12	investigate	investigate	VERB
bjp-59809	131	13	the	the	DET
bjp-59809	131	14	molecular	molecular	ADJ
bjp-59809	131	15	mechanism	mechanism	NOUN
bjp-59809	131	16	of	of	ADP
bjp-59809	131	17	ak-7	ak-7	CCONJ
bjp-59809	131	18	inducing	induce	VERB
bjp-59809	131	19	apoptosis	apoptosis	NOUN
bjp-59809	131	20	of	of	ADP
bjp-59809	131	21	u87	u87	ADJ
bjp-59809	131	22	glioblastoma	glioblastoma	NOUN
bjp-59809	131	23	multiforme	multiforme	NOUN
bjp-59809	131	24	cells	cell	NOUN
bjp-59809	131	25	,	,	PUNCT
bjp-59809	131	26	mrna	mrna	NOUN
bjp-59809	131	27	expression	expression	NOUN
bjp-59809	131	28	levels	level	NOUN
bjp-59809	131	29	of	of	ADP
bjp-59809	131	30	cell	cell	NOUN
bjp-59809	131	31	apoptosis	apoptosis	NOUN
bjp-59809	131	32	-	-	PUNCT
bjp-59809	131	33	related	relate	VERB
bjp-59809	131	34	genes	gene	NOUN
bjp-59809	131	35	were	be	AUX
bjp-59809	131	36	determined	determine	VERB
bjp-59809	131	37	by	by	ADP
bjp-59809	131	38	qrt	qrt	NOUN
bjp-59809	131	39	-	-	PUNCT
bjp-59809	131	40	pcr	pcr	ADJ
bjp-59809	131	41	.	.	PUNCT
bjp-59809	132	1	analysis	analysis	NOUN
bjp-59809	132	2	of	of	ADP
bjp-59809	132	3	mrna	mrna	PROPN
bjp-59809	132	4	expression	expression	NOUN
bjp-59809	132	5	levels	level	NOUN
bjp-59809	132	6	of	of	ADP
bjp-59809	132	7	genes	gene	NOUN
bjp-59809	132	8	after	after	ADP
bjp-59809	132	9	treatment	treatment	NOUN
bjp-59809	132	10	of	of	ADP
bjp-59809	132	11	75	75	NUM
bjp-59809	132	12	and	and	CCONJ
bjp-59809	132	13	100	100	NUM
bjp-59809	132	14	µm	µm	ADP
bjp-59809	132	15	doses	dose	NOUN
bjp-59809	132	16	of	of	ADP
bjp-59809	132	17	ak-7	ak-7	ADV
bjp-59809	132	18	was	be	AUX
bjp-59809	132	19	compared	compare	VERB
bjp-59809	132	20	with	with	ADP
bjp-59809	132	21	control	control	NOUN
bjp-59809	132	22	group	group	NOUN
bjp-59809	132	23	cells	cell	NOUN
bjp-59809	132	24	and	and	CCONJ
bjp-59809	132	25	the	the	DET
bjp-59809	132	26	differences	difference	NOUN
bjp-59809	132	27	between	between	ADP
bjp-59809	132	28	groups	group	NOUN
bjp-59809	132	29	were	be	AUX
bjp-59809	132	30	shown	show	VERB
bjp-59809	132	31	in	in	ADP
bjp-59809	132	32	figure	figure	NOUN
bjp-59809	132	33	3a	3a	NUM
bjp-59809	132	34	.	.	PUNCT
bjp-59809	133	1	the	the	DET
bjp-59809	133	2	mrna	mrna	PROPN
bjp-59809	133	3	expression	expression	NOUN
bjp-59809	133	4	levels	level	NOUN
bjp-59809	133	5	of	of	ADP
bjp-59809	133	6	casp7	casp7	PROPN
bjp-59809	133	7	,	,	PUNCT
bjp-59809	133	8	casp8	casp8	PROPN
bjp-59809	133	9	,	,	PUNCT
bjp-59809	133	10	casp10	casp10	PROPN
bjp-59809	133	11	,	,	PUNCT
bjp-59809	133	12	cycs	cycs	PROPN
bjp-59809	133	13	,	,	PUNCT
bjp-59809	133	14	pparg	pparg	NOUN
bjp-59809	133	15	,	,	PUNCT
bjp-59809	133	16	fas	fas	NOUN
bjp-59809	133	17	,	,	PUNCT
bjp-59809	133	18	fadd	fadd	NOUN
bjp-59809	133	19	increased	increase	VERB
bjp-59809	133	20	in	in	ADP
bjp-59809	133	21	cells	cell	NOUN
bjp-59809	133	22	treated	treat	VERB
bjp-59809	133	23	with	with	ADP
bjp-59809	133	24	both	both	DET
bjp-59809	133	25	dose	dose	VERB
bjp-59809	133	26	groups	group	NOUN
bjp-59809	133	27	of	of	ADP
bjp-59809	133	28	ak-7	ak-7	PROPN
bjp-59809	133	29	.	.	PUNCT
bjp-59809	134	1	additionally	additionally	ADV
bjp-59809	134	2	,	,	PUNCT
bjp-59809	134	3	it	it	PRON
bjp-59809	134	4	was	be	AUX
bjp-59809	134	5	found	find	VERB
bjp-59809	134	6	that	that	SCONJ
bjp-59809	134	7	casp9	casp9	NOUN
bjp-59809	134	8	,	,	PUNCT
bjp-59809	134	9	tnf	tnf	PROPN
bjp-59809	134	10	,	,	PUNCT
bjp-59809	134	11	tnfr1	tnfr1	NOUN
bjp-59809	134	12	and	and	CCONJ
bjp-59809	134	13	tnfr2	tnfr2	ADJ
bjp-59809	134	14	mrna	mrna	NOUN
bjp-59809	134	15	expression	expression	NOUN
bjp-59809	134	16	levels	level	NOUN
bjp-59809	134	17	increased	increase	VERB
bjp-59809	134	18	significantly	significantly	ADV
bjp-59809	134	19	only	only	ADV
bjp-59809	134	20	in	in	ADP
bjp-59809	134	21	cells	cell	NOUN
bjp-59809	134	22	treated	treat	VERB
bjp-59809	134	23	with	with	ADP
bjp-59809	134	24	100	100	NUM
bjp-59809	134	25	µm	µm	ADP
bjp-59809	134	26	ak-7	ak-7	CCONJ
bjp-59809	134	27	dose	dose	NOUN
bjp-59809	134	28	group	group	NOUN
bjp-59809	134	29	.	.	PUNCT
bjp-59809	135	1	according	accord	VERB
bjp-59809	135	2	to	to	ADP
bjp-59809	135	3	the	the	DET
bjp-59809	135	4	results	result	NOUN
bjp-59809	135	5	of	of	ADP
bjp-59809	135	6	caspase-3	caspase-3	NUM
bjp-59809	135	7	activity	activity	NOUN
bjp-59809	135	8	test	test	NOUN
bjp-59809	135	9	,	,	PUNCT
bjp-59809	135	10	the	the	DET
bjp-59809	135	11	fold	fold	ADJ
bjp-59809	135	12	change	change	NOUN
bjp-59809	135	13	of	of	ADP
bjp-59809	135	14	75	75	NUM
bjp-59809	135	15	and	and	CCONJ
bjp-59809	135	16	100	100	NUM
bjp-59809	135	17	µm	µm	ADP
bjp-59809	135	18	dose	dose	NOUN
bjp-59809	135	19	groups	group	NOUN
bjp-59809	135	20	of	of	ADP
bjp-59809	135	21	ak-7	ak-7	CCONJ
bjp-59809	135	22	increased	increase	VERB
bjp-59809	135	23	significantly	significantly	ADV
bjp-59809	135	24	compared	compare	VERB
bjp-59809	135	25	to	to	ADP
bjp-59809	135	26	the	the	DET
bjp-59809	135	27	control	control	NOUN
bjp-59809	135	28	group	group	NOUN
bjp-59809	135	29	,	,	PUNCT
bjp-59809	135	30	and	and	CCONJ
bjp-59809	135	31	there	there	PRON
bjp-59809	135	32	was	be	VERB
bjp-59809	135	33	also	also	ADV
bjp-59809	135	34	a	a	DET
bjp-59809	135	35	significant	significant	ADJ
bjp-59809	135	36	difference	difference	NOUN
bjp-59809	135	37	between	between	ADP
bjp-59809	135	38	the	the	DET
bjp-59809	135	39	75	75	NUM
bjp-59809	135	40	and	and	CCONJ
bjp-59809	135	41	100	100	NUM
bjp-59809	135	42	µm	µm	ADP
bjp-59809	135	43	dose	dose	NOUN
bjp-59809	135	44	groups	group	NOUN
bjp-59809	135	45	of	of	ADP
bjp-59809	135	46	ak-7	ak-7	PROPN
bjp-59809	135	47	(	(	PUNCT
bjp-59809	135	48	figure	figure	NOUN
bjp-59809	135	49	3b	3b	NUM
bjp-59809	135	50	)	)	PUNCT
bjp-59809	135	51	(	(	PUNCT
bjp-59809	135	52	p<0.05	p<0.05	NOUN
bjp-59809	135	53	)	)	PUNCT
bjp-59809	135	54	.	.	PUNCT
bjp-59809	136	1	discussion	discussion	NOUN
bjp-59809	136	2	targeting	target	VERB
bjp-59809	136	3	various	various	ADJ
bjp-59809	136	4	molecules	molecule	NOUN
bjp-59809	136	5	that	that	PRON
bjp-59809	136	6	play	play	VERB
bjp-59809	136	7	a	a	DET
bjp-59809	136	8	role	role	NOUN
bjp-59809	136	9	in	in	ADP
bjp-59809	136	10	tumor	tumor	NOUN
bjp-59809	136	11	development	development	NOUN
bjp-59809	136	12	is	be	AUX
bjp-59809	136	13	one	one	NUM
bjp-59809	136	14	of	of	ADP
bjp-59809	136	15	the	the	DET
bjp-59809	136	16	important	important	ADJ
bjp-59809	136	17	therapeutic	therapeutic	ADJ
bjp-59809	136	18	approaches	approach	NOUN
bjp-59809	136	19	to	to	ADP
bjp-59809	136	20	cancer	cancer	NOUN
bjp-59809	136	21	.	.	PUNCT
bjp-59809	137	1	one	one	NUM
bjp-59809	137	2	of	of	ADP
bjp-59809	137	3	these	these	DET
bjp-59809	137	4	molecular	molecular	ADJ
bjp-59809	137	5	targets	target	NOUN
bjp-59809	137	6	is	be	AUX
bjp-59809	137	7	sirts	sirt	NOUN
bjp-59809	137	8	,	,	PUNCT
bjp-59809	137	9	known	know	VERB
bjp-59809	137	10	as	as	ADP
bjp-59809	137	11	nad+	nad+	PROPN
bjp-59809	137	12	dependent	dependent	ADJ
bjp-59809	137	13	class	class	NOUN
bjp-59809	137	14	iii	iii	NUM
bjp-59809	137	15	histondeacetylases	histondeacetylase	NOUN
bjp-59809	137	16	.	.	PUNCT
bjp-59809	138	1	sirt2	sirt2	PROPN
bjp-59809	138	2	,	,	PUNCT
bjp-59809	138	3	which	which	PRON
bjp-59809	138	4	is	be	AUX
bjp-59809	138	5	in	in	ADP
bjp-59809	138	6	the	the	DET
bjp-59809	138	7	sirt	sirt	PROPN
bjp-59809	138	8	family	family	NOUN
bjp-59809	138	9	,	,	PUNCT
bjp-59809	138	10	is	be	AUX
bjp-59809	138	11	associated	associate	VERB
bjp-59809	138	12	with	with	ADP
bjp-59809	138	13	various	various	ADJ
bjp-59809	138	14	physiological	physiological	ADJ
bjp-59809	138	15	and	and	CCONJ
bjp-59809	138	16	pathological	pathological	ADJ
bjp-59809	138	17	processes	process	NOUN
bjp-59809	138	18	and	and	CCONJ
bjp-59809	138	19	has	have	VERB
bjp-59809	138	20	a	a	DET
bjp-59809	138	21	controversial	controversial	ADJ
bjp-59809	138	22	role	role	NOUN
bjp-59809	138	23	as	as	ADP
bjp-59809	138	24	a	a	DET
bjp-59809	138	25	tumor	tumor	NOUN
bjp-59809	138	26	suppressor	suppressor	NOUN
bjp-59809	138	27	or	or	CCONJ
bjp-59809	138	28	tumor	tumor	NOUN
bjp-59809	138	29	promoter	promoter	NOUN
bjp-59809	138	30	in	in	ADP
bjp-59809	138	31	cancer	cancer	NOUN
bjp-59809	138	32	(	(	PUNCT
bjp-59809	138	33	roshdy	roshdy	NOUN
bjp-59809	138	34	et	et	NOUN
bjp-59809	138	35	al	al	PROPN
bjp-59809	138	36	.	.	PROPN
bjp-59809	138	37	,	,	PUNCT
bjp-59809	138	38	2021	2021	NUM
bjp-59809	138	39	)	)	PUNCT
bjp-59809	138	40	.	.	PUNCT
bjp-59809	139	1	the	the	DET
bjp-59809	139	2	tumor	tumor	NOUN
bjp-59809	139	3	suppressive	suppressive	ADJ
bjp-59809	139	4	property	property	NOUN
bjp-59809	139	5	of	of	ADP
bjp-59809	139	6	sirt2	sirt2	PROPN
bjp-59809	139	7	is	be	AUX
bjp-59809	139	8	associated	associate	VERB
bjp-59809	139	9	with	with	ADP
bjp-59809	139	10	maintaining	maintain	VERB
bjp-59809	139	11	genome	genome	NOUN
bjp-59809	139	12	integrity	integrity	NOUN
bjp-59809	139	13	and	and	CCONJ
bjp-59809	139	14	regulating	regulate	VERB
bjp-59809	139	15	the	the	DET
bjp-59809	139	16	anaphase	anaphase	NOUN
bjp-59809	139	17	-	-	PUNCT
bjp-59809	139	18	promoting	promote	VERB
bjp-59809	139	19	complex	complex	ADJ
bjp-59809	139	20	/	/	SYM
bjp-59809	139	21	cyclosome	cyclosome	ADJ
bjp-59809	139	22	activity	activity	NOUN
bjp-59809	139	23	.	.	PUNCT
bjp-59809	140	1	furthermore	furthermore	ADV
bjp-59809	140	2	,	,	PUNCT
bjp-59809	140	3	sirt2	sirt2	NOUN
bjp-59809	140	4	deficiency	deficiency	NOUN
bjp-59809	140	5	in	in	ADP
bjp-59809	140	6	mice	mouse	NOUN
bjp-59809	140	7	has	have	AUX
bjp-59809	140	8	been	be	AUX
bjp-59809	140	9	shown	show	VERB
bjp-59809	140	10	to	to	PART
bjp-59809	140	11	cause	cause	VERB
bjp-59809	140	12	genetic	genetic	ADJ
bjp-59809	140	13	instability	instability	NOUN
bjp-59809	140	14	and	and	CCONJ
bjp-59809	140	15	tumorigenesis	tumorigenesis	NOUN
bjp-59809	140	16	(	(	PUNCT
bjp-59809	140	17	kim	kim	PROPN
bjp-59809	140	18	et	et	PROPN
bjp-59809	140	19	al	al	PROPN
bjp-59809	140	20	.	.	PROPN
bjp-59809	140	21	,	,	PUNCT
bjp-59809	140	22	2011	2011	NUM
bjp-59809	140	23	)	)	PUNCT
bjp-59809	140	24	.	.	PUNCT
bjp-59809	141	1	sirt2	sirt2	PROPN
bjp-59809	141	2	negatively	negatively	ADV
bjp-59809	141	3	regulates	regulate	VERB
bjp-59809	141	4	the	the	DET
bjp-59809	141	5	expression	expression	NOUN
bjp-59809	141	6	of	of	ADP
bjp-59809	141	7	jmjd2a	jmjd2a	PROPN
bjp-59809	141	8	,	,	PUNCT
bjp-59809	141	9	which	which	PRON
bjp-59809	141	10	is	be	AUX
bjp-59809	141	11	associated	associate	VERB
bjp-59809	141	12	with	with	ADP
bjp-59809	141	13	poor	poor	ADJ
bjp-59809	141	14	survival	survival	NOUN
bjp-59809	141	15	in	in	ADP
bjp-59809	141	16	non	non	ADJ
bjp-59809	141	17	–	–	ADJ
bjp-59809	141	18	small	small	ADJ
bjp-59809	141	19	cell	cell	NOUN
bjp-59809	141	20	lung	lung	NOUN
bjp-59809	141	21	cancer	cancer	NOUN
bjp-59809	141	22	(	(	PUNCT
bjp-59809	141	23	nsclc	nsclc	NOUN
bjp-59809	141	24	)	)	PUNCT
bjp-59809	141	25	,	,	PUNCT
bjp-59809	141	26	and	and	CCONJ
bjp-59809	141	27	inhibits	inhibit	VERB
bjp-59809	141	28	proliferation	proliferation	NOUN
bjp-59809	141	29	,	,	PUNCT
bjp-59809	141	30	colony	colony	NOUN
bjp-59809	141	31	formation	formation	NOUN
bjp-59809	141	32	,	,	PUNCT
bjp-59809	141	33	and	and	CCONJ
bjp-59809	141	34	tumor	tumor	NOUN
bjp-59809	141	35	growth	growth	NOUN
bjp-59809	141	36	of	of	ADP
bjp-59809	141	37	nsclc	nsclc	NOUN
bjp-59809	141	38	cells	cell	NOUN
bjp-59809	141	39	(	(	PUNCT
bjp-59809	141	40	xu	xu	INTJ
bjp-59809	141	41	et	et	PROPN
bjp-59809	141	42	al	al	PROPN
bjp-59809	141	43	.	.	PROPN
bjp-59809	141	44	,	,	PUNCT
bjp-59809	141	45	2015	2015	NUM
bjp-59809	141	46	)	)	PUNCT
bjp-59809	141	47	.	.	PUNCT
bjp-59809	142	1	in	in	ADP
bjp-59809	142	2	colorectal	colorectal	ADJ
bjp-59809	142	3	cancer	cancer	NOUN
bjp-59809	142	4	cells	cell	NOUN
bjp-59809	142	5	,	,	PUNCT
bjp-59809	142	6	sirt2	sirt2	PROPN
bjp-59809	142	7	is	be	AUX
bjp-59809	142	8	one	one	NUM
bjp-59809	142	9	of	of	ADP
bjp-59809	142	10	the	the	DET
bjp-59809	142	11	targets	target	NOUN
bjp-59809	142	12	of	of	ADP
bjp-59809	142	13	wnt	wnt	PROPN
bjp-59809	142	14	/	/	SYM
bjp-59809	142	15	β	β	NOUN
bjp-59809	142	16	-	-	ADJ
bjp-59809	142	17	catenin	catenin	NOUN
bjp-59809	142	18	signaling	signaling	NOUN
bjp-59809	142	19	and	and	CCONJ
bjp-59809	142	20	has	have	VERB
bjp-59809	142	21	a	a	DET
bjp-59809	142	22	tumor	tumor	NOUN
bjp-59809	142	23	suppressor	suppressor	NOUN
bjp-59809	142	24	role	role	NOUN
bjp-59809	142	25	by	by	ADP
bjp-59809	142	26	enabling	enable	VERB
bjp-59809	142	27	the	the	DET
bjp-59809	142	28	differentiation	differentiation	NOUN
bjp-59809	142	29	of	of	ADP
bjp-59809	142	30	colorectal	colorectal	ADJ
bjp-59809	142	31	cancer	cancer	NOUN
bjp-59809	142	32	cells	cell	NOUN
bjp-59809	142	33	(	(	PUNCT
bjp-59809	142	34	li	li	PROPN
bjp-59809	142	35	et	et	PROPN
bjp-59809	142	36	al	al	PROPN
bjp-59809	142	37	.	.	PROPN
bjp-59809	142	38	,	,	PUNCT
bjp-59809	142	39	2021	2021	NUM
bjp-59809	142	40	)	)	PUNCT
bjp-59809	142	41	.	.	PUNCT
bjp-59809	143	1	the	the	DET
bjp-59809	143	2	lack	lack	NOUN
bjp-59809	143	3	of	of	ADP
bjp-59809	143	4	figure	figure	NOUN
bjp-59809	143	5	2	2	NUM
bjp-59809	143	6	:	:	PUNCT
bjp-59809	143	7	ak-7	ak-7	CCONJ
bjp-59809	143	8	promoted	promote	VERB
bjp-59809	143	9	apoptosis	apoptosis	NOUN
bjp-59809	143	10	of	of	ADP
bjp-59809	143	11	u87	u87	ADJ
bjp-59809	143	12	glioblastoma	glioblastoma	NOUN
bjp-59809	143	13	multiforme	multiforme	NOUN
bjp-59809	143	14	cells	cell	NOUN
bjp-59809	143	15	.	.	PUNCT
bjp-59809	144	1	u87	u87	ADJ
bjp-59809	144	2	cells	cell	NOUN
bjp-59809	144	3	were	be	AUX
bjp-59809	144	4	treated	treat	VERB
bjp-59809	144	5	with	with	ADP
bjp-59809	144	6	two	two	NUM
bjp-59809	144	7	different	different	ADJ
bjp-59809	144	8	concentrations	concentration	NOUN
bjp-59809	144	9	(	(	PUNCT
bjp-59809	144	10	75	75	NUM
bjp-59809	144	11	and	and	CCONJ
bjp-59809	144	12	100	100	NUM
bjp-59809	144	13	μm	μm	NUM
bjp-59809	144	14	)	)	PUNCT
bjp-59809	144	15	of	of	ADP
bjp-59809	144	16	ak-7	ak-7	ADV
bjp-59809	144	17	for	for	ADP
bjp-59809	144	18	48	48	NUM
bjp-59809	144	19	hours	hour	NOUN
bjp-59809	144	20	.	.	PUNCT
bjp-59809	145	1	after	after	ADP
bjp-59809	145	2	treatment	treatment	NOUN
bjp-59809	145	3	,	,	PUNCT
bjp-59809	145	4	annexin	annexin	PROPN
bjp-59809	145	5	v/7	v/7	NOUN
bjp-59809	145	6	-	-	PUNCT
bjp-59809	145	7	aad	aad	NOUN
bjp-59809	145	8	analysis	analysis	NOUN
bjp-59809	145	9	was	be	AUX
bjp-59809	145	10	performed	perform	VERB
bjp-59809	145	11	to	to	PART
bjp-59809	145	12	determine	determine	VERB
bjp-59809	145	13	the	the	DET
bjp-59809	145	14	necrotic	necrotic	ADJ
bjp-59809	145	15	,	,	PUNCT
bjp-59809	145	16	early	early	ADJ
bjp-59809	145	17	and	and	CCONJ
bjp-59809	145	18	late	late	ADJ
bjp-59809	145	19	apoptotic	apoptotic	ADJ
bjp-59809	145	20	cells	cell	NOUN
bjp-59809	145	21	in	in	ADP
bjp-59809	145	22	each	each	DET
bjp-59809	145	23	group	group	NOUN
bjp-59809	145	24	(	(	PUNCT
bjp-59809	145	25	a	a	PROPN
bjp-59809	145	26	-	-	PUNCT
bjp-59809	145	27	b	b	NOUN
bjp-59809	145	28	)	)	PUNCT
bjp-59809	145	29	.	.	PUNCT
bjp-59809	146	1	apoptotic	apoptotic	ADJ
bjp-59809	146	2	cell	cell	NOUN
bjp-59809	146	3	death	death	NOUN
bjp-59809	146	4	due	due	ADP
bjp-59809	146	5	to	to	ADP
bjp-59809	146	6	dna	dna	PROPN
bjp-59809	146	7	fragmentation	fragmentation	NOUN
bjp-59809	146	8	was	be	AUX
bjp-59809	146	9	evaluated	evaluate	VERB
bjp-59809	146	10	using	use	VERB
bjp-59809	146	11	a	a	DET
bjp-59809	146	12	cell	cell	NOUN
bjp-59809	146	13	death	death	NOUN
bjp-59809	146	14	detection	detection	NOUN
bjp-59809	146	15	elisaplus	elisaplus	ADJ
bjp-59809	146	16	kit	kit	NOUN
bjp-59809	146	17	(	(	PUNCT
bjp-59809	146	18	ap<0.01	ap<0.01	PROPN
bjp-59809	146	19	,	,	PUNCT
bjp-59809	146	20	bp<0.001	bp<0.001	PROPN
bjp-59809	146	21	)	)	PUNCT
bjp-59809	146	22	(	(	PUNCT
bjp-59809	146	23	c	c	X
bjp-59809	146	24	)	)	PUNCT
bjp-59809	146	25	a	a	DET
bjp-59809	146	26	control	control	NOUN
bjp-59809	146	27	ak-7	ak-7	ADP
bjp-59809	146	28	(	(	PUNCT
bjp-59809	146	29	75	75	NUM
bjp-59809	146	30	µm	µm	NOUN
bjp-59809	146	31	)	)	PUNCT
bjp-59809	146	32	ak-7	ak-7	ADP
bjp-59809	147	1	(	(	PUNCT
bjp-59809	147	2	100	100	NUM
bjp-59809	147	3	µm	µm	NOUN
bjp-59809	147	4	)	)	PUNCT
bjp-59809	147	5	b	b	NOUN
bjp-59809	147	6	c	c	PROPN
bjp-59809	147	7	a	a	DET
bjp-59809	147	8	p	p	X
bjp-59809	147	9	o	o	X
bjp-59809	147	10	p	p	NOUN
bjp-59809	147	11	to	to	ADP
bjp-59809	147	12	s	s	PRON
bjp-59809	147	13	is	be	AUX
bjp-59809	147	14	r	r	NOUN
bjp-59809	147	15	a	a	DET
bjp-59809	147	16	te	te	PROPN
bjp-59809	147	17	(	(	PUNCT
bjp-59809	147	18	%	%	NOUN
bjp-59809	147	19	)	)	PUNCT
bjp-59809	148	1	60	60	NUM
bjp-59809	148	2	0	0	NUM
bjp-59809	148	3	40	40	NUM
bjp-59809	148	4	20	20	NUM
bjp-59809	148	5	80	80	NUM
bjp-59809	148	6	ak-7	ak-7	ADP
bjp-59809	148	7	0	0	NUM
bjp-59809	148	8	75	75	NUM
bjp-59809	148	9	ak-7	ak-7	CCONJ
bjp-59809	148	10	0	0	NUM
bjp-59809	148	11	75	75	NUM
bjp-59809	148	12	100	100	NUM
bjp-59809	148	13	µm	µm	ADP
bjp-59809	148	14	a	a	DET
bjp-59809	148	15	p	p	NOUN
bjp-59809	148	16	o	o	X
bjp-59809	148	17	p	p	NOUN
bjp-59809	148	18	to	to	ADP
bjp-59809	148	19	s	s	PRON
bjp-59809	148	20	is	be	AUX
bjp-59809	148	21	i	i	PRON
bjp-59809	148	22	n	n	ADV
bjp-59809	148	23	d	d	X
bjp-59809	148	24	e	e	X
bjp-59809	148	25	x	x	PROPN
bjp-59809	148	26	2	2	NUM
bjp-59809	148	27	0	0	NUM
bjp-59809	148	28	3	3	NUM
bjp-59809	148	29	1	1	NUM
bjp-59809	148	30	0	0	NUM
bjp-59809	148	31	a	a	DET
bjp-59809	148	32	a	a	DET
bjp-59809	148	33	a	a	DET
bjp-59809	148	34	b	b	PROPN
bjp-59809	148	35	b	b	PROPN
bjp-59809	148	36	b	b	PROPN
bjp-59809	148	37	46	46	NUM
bjp-59809	148	38	bangladesh	bangladesh	PROPN
bjp-59809	148	39	j	j	PROPN
bjp-59809	148	40	pharmacol	pharmacol	PROPN
bjp-59809	148	41	2022	2022	NUM
bjp-59809	148	42	;	;	PUNCT
bjp-59809	148	43	17	17	NUM
bjp-59809	148	44	:	:	SYM
bjp-59809	148	45	42	42	NUM
bjp-59809	148	46	-	-	SYM
bjp-59809	148	47	50	50	NUM
bjp-59809	148	48	suppression	suppression	NOUN
bjp-59809	148	49	of	of	ADP
bjp-59809	148	50	cyclin	cyclin	NOUN
bjp-59809	148	51	-	-	PUNCT
bjp-59809	148	52	dependent	dependent	ADJ
bjp-59809	148	53	kinase	kinase	NOUN
bjp-59809	148	54	4	4	NUM
bjp-59809	148	55	due	due	ADP
bjp-59809	148	56	to	to	ADP
bjp-59809	148	57	the	the	DET
bjp-59809	148	58	decrease	decrease	NOUN
bjp-59809	148	59	in	in	ADP
bjp-59809	148	60	sirt2	sirt2	PROPN
bjp-59809	148	61	expression	expression	NOUN
bjp-59809	148	62	increases	increase	VERB
bjp-59809	148	63	the	the	DET
bjp-59809	148	64	proliferation	proliferation	NOUN
bjp-59809	148	65	of	of	ADP
bjp-59809	148	66	ovarian	ovarian	ADJ
bjp-59809	148	67	cancer	cancer	NOUN
bjp-59809	148	68	cells	cell	NOUN
bjp-59809	148	69	(	(	PUNCT
bjp-59809	148	70	du	du	X
bjp-59809	148	71	et	et	PROPN
bjp-59809	148	72	al	al	PROPN
bjp-59809	148	73	.	.	PROPN
bjp-59809	148	74	,	,	PUNCT
bjp-59809	148	75	2017	2017	NUM
bjp-59809	148	76	)	)	PUNCT
bjp-59809	148	77	.	.	PUNCT
bjp-59809	149	1	in	in	ADP
bjp-59809	149	2	addition	addition	NOUN
bjp-59809	149	3	,	,	PUNCT
bjp-59809	149	4	sirt2	sirt2	PROPN
bjp-59809	149	5	overexpression	overexpression	NOUN
bjp-59809	149	6	increases	increase	VERB
bjp-59809	149	7	the	the	DET
bjp-59809	149	8	cisplatin	cisplatin	NOUN
bjp-59809	149	9	sensitivity	sensitivity	NOUN
bjp-59809	149	10	of	of	ADP
bjp-59809	149	11	cisplatin	cisplatin	NOUN
bjp-59809	149	12	-	-	PUNCT
bjp-59809	149	13	resistant	resistant	ADJ
bjp-59809	149	14	ovarian	ovarian	ADJ
bjp-59809	149	15	cancer	cancer	NOUN
bjp-59809	149	16	cells	cell	NOUN
bjp-59809	149	17	(	(	PUNCT
bjp-59809	149	18	wang	wang	PROPN
bjp-59809	149	19	et	et	PROPN
bjp-59809	149	20	al	al	PROPN
bjp-59809	149	21	.	.	PROPN
bjp-59809	149	22	,	,	PUNCT
bjp-59809	149	23	2020	2020	NUM
bjp-59809	149	24	)	)	PUNCT
bjp-59809	149	25	.	.	PUNCT
bjp-59809	150	1	sirt2	sirt2	PROPN
bjp-59809	150	2	can	can	AUX
bjp-59809	150	3	also	also	ADV
bjp-59809	150	4	contribute	contribute	VERB
bjp-59809	150	5	to	to	ADP
bjp-59809	150	6	the	the	DET
bjp-59809	150	7	duration	duration	NOUN
bjp-59809	150	8	of	of	ADP
bjp-59809	150	9	tumorigenesis	tumorigenesis	NOUN
bjp-59809	150	10	by	by	ADP
bjp-59809	150	11	various	various	ADJ
bjp-59809	150	12	mechanisms	mechanism	NOUN
bjp-59809	150	13	.	.	PUNCT
bjp-59809	151	1	in	in	ADP
bjp-59809	151	2	a	a	DET
bjp-59809	151	3	study	study	NOUN
bjp-59809	151	4	with	with	ADP
bjp-59809	151	5	glioblastoma	glioblastoma	NOUN
bjp-59809	151	6	cells	cell	NOUN
bjp-59809	151	7	,	,	PUNCT
bjp-59809	151	8	sirt2	sirt2	PROPN
bjp-59809	151	9	regulates	regulate	VERB
bjp-59809	151	10	the	the	DET
bjp-59809	151	11	transcriptional	transcriptional	ADJ
bjp-59809	151	12	activity	activity	NOUN
bjp-59809	151	13	of	of	ADP
bjp-59809	151	14	p73	p73	NOUN
bjp-59809	151	15	and	and	CCONJ
bjp-59809	151	16	contributes	contribute	VERB
bjp-59809	151	17	to	to	ADP
bjp-59809	151	18	the	the	DET
bjp-59809	151	19	proliferation	proliferation	NOUN
bjp-59809	151	20	of	of	ADP
bjp-59809	151	21	glioma	glioma	NOUN
bjp-59809	151	22	stem	stem	NOUN
bjp-59809	151	23	cells	cell	NOUN
bjp-59809	151	24	and	and	CCONJ
bjp-59809	151	25	glioma	glioma	NOUN
bjp-59809	151	26	cells	cell	NOUN
bjp-59809	151	27	(	(	PUNCT
bjp-59809	151	28	funato	funato	X
bjp-59809	151	29	et	et	PROPN
bjp-59809	151	30	al	al	PROPN
bjp-59809	151	31	.	.	PROPN
bjp-59809	151	32	,	,	PUNCT
bjp-59809	151	33	2018	2018	NUM
bjp-59809	151	34	)	)	PUNCT
bjp-59809	151	35	.	.	PUNCT
bjp-59809	152	1	sirt2	sirt2	PROPN
bjp-59809	152	2	induces	induce	VERB
bjp-59809	152	3	epithelial	epithelial	ADJ
bjp-59809	152	4	-	-	PUNCT
bjp-59809	152	5	mesenchymal	mesenchymal	NOUN
bjp-59809	152	6	transition	transition	NOUN
bjp-59809	152	7	through	through	ADP
bjp-59809	152	8	the	the	DET
bjp-59809	152	9	glycogen	glycogen	NOUN
bjp-59809	152	10	synthase	synthase	NOUN
bjp-59809	152	11	kinase-3β	kinase-3β	PROPN
bjp-59809	152	12	/	/	SYM
bjp-59809	152	13	β	β	NOUN
bjp-59809	152	14	-	-	ADJ
bjp-59809	152	15	catenin	catenin	ADJ
bjp-59809	152	16	pathway	pathway	NOUN
bjp-59809	152	17	in	in	ADP
bjp-59809	152	18	hepatocellular	hepatocellular	ADJ
bjp-59809	152	19	carcinoma	carcinoma	NOUN
bjp-59809	152	20	(	(	PUNCT
bjp-59809	152	21	hcc	hcc	PROPN
bjp-59809	152	22	)	)	PUNCT
bjp-59809	152	23	,	,	PUNCT
bjp-59809	152	24	and	and	CCONJ
bjp-59809	152	25	downregulation	downregulation	NOUN
bjp-59809	152	26	of	of	ADP
bjp-59809	152	27	sirt2	sirt2	PROPN
bjp-59809	152	28	reduces	reduce	VERB
bjp-59809	152	29	migration	migration	NOUN
bjp-59809	152	30	and	and	CCONJ
bjp-59809	152	31	invasion	invasion	NOUN
bjp-59809	152	32	in	in	ADP
bjp-59809	152	33	hcc	hcc	PROPN
bjp-59809	152	34	cells	cell	NOUN
bjp-59809	152	35	(	(	PUNCT
bjp-59809	152	36	chen	chen	PROPN
bjp-59809	152	37	et	et	PROPN
bjp-59809	152	38	al	al	PROPN
bjp-59809	152	39	.	.	PROPN
bjp-59809	152	40	,	,	PUNCT
bjp-59809	152	41	2013	2013	NUM
bjp-59809	152	42	;	;	PUNCT
bjp-59809	153	1	huang	huang	PROPN
bjp-59809	153	2	et	et	PROPN
bjp-59809	153	3	al	al	PROPN
bjp-59809	153	4	.	.	PROPN
bjp-59809	153	5	,	,	PUNCT
bjp-59809	153	6	2017	2017	NUM
bjp-59809	153	7	)	)	PUNCT
bjp-59809	153	8	.	.	PUNCT
bjp-59809	154	1	hu	hu	PROPN
bjp-59809	154	2	et	et	PROPN
bjp-59809	154	3	al	al	PROPN
bjp-59809	154	4	.	.	PROPN
bjp-59809	155	1	(	(	PUNCT
bjp-59809	155	2	2018	2018	NUM
bjp-59809	155	3	)	)	PUNCT
bjp-59809	155	4	reported	report	VERB
bjp-59809	155	5	that	that	SCONJ
bjp-59809	155	6	sirt2	sirt2	PROPN
bjp-59809	155	7	expression	expression	NOUN
bjp-59809	155	8	is	be	AUX
bjp-59809	155	9	high	high	ADJ
bjp-59809	155	10	in	in	ADP
bjp-59809	155	11	colorectal	colorectal	ADJ
bjp-59809	155	12	cancer	cancer	NOUN
bjp-59809	155	13	tissues	tissue	NOUN
bjp-59809	155	14	,	,	PUNCT
bjp-59809	155	15	and	and	CCONJ
bjp-59809	155	16	silencing	silence	VERB
bjp-59809	155	17	of	of	ADP
bjp-59809	155	18	sirt2	sirt2	PROPN
bjp-59809	155	19	suppresses	suppress	VERB
bjp-59809	155	20	tumor	tumor	NOUN
bjp-59809	155	21	angiogenesis	angiogenesis	NOUN
bjp-59809	155	22	through	through	ADP
bjp-59809	155	23	stat3	stat3	NOUN
bjp-59809	155	24	/	/	SYM
bjp-59809	155	25	vegfa	vegfa	PROPN
bjp-59809	155	26	inactivation	inactivation	NOUN
bjp-59809	155	27	.	.	PUNCT
bjp-59809	156	1	similarly	similarly	ADV
bjp-59809	156	2	,	,	PUNCT
bjp-59809	156	3	sirt2	sirt2	PROPN
bjp-59809	156	4	expression	expression	NOUN
bjp-59809	156	5	is	be	AUX
bjp-59809	156	6	high	high	ADJ
bjp-59809	156	7	in	in	ADP
bjp-59809	156	8	patients	patient	NOUN
bjp-59809	156	9	with	with	ADP
bjp-59809	156	10	relapsing	relapse	VERB
bjp-59809	156	11	acute	acute	ADJ
bjp-59809	156	12	myeloid	myeloid	ADJ
bjp-59809	156	13	leukemia	leukemia	NOUN
bjp-59809	156	14	,	,	PUNCT
bjp-59809	156	15	and	and	CCONJ
bjp-59809	156	16	silencing	silence	VERB
bjp-59809	156	17	of	of	ADP
bjp-59809	156	18	sirt2	sirt2	PROPN
bjp-59809	156	19	in	in	ADP
bjp-59809	156	20	drug	drug	NOUN
bjp-59809	156	21	-	-	PUNCT
bjp-59809	156	22	resistant	resistant	ADJ
bjp-59809	156	23	hl60	hl60	PROPN
bjp-59809	156	24	/	/	SYM
bjp-59809	156	25	a	a	DET
bjp-59809	156	26	cells	cell	NOUN
bjp-59809	156	27	decreases	decrease	VERB
bjp-59809	156	28	mrp1	mrp1	NOUN
bjp-59809	156	29	levels	level	NOUN
bjp-59809	156	30	,	,	PUNCT
bjp-59809	156	31	increases	increase	VERB
bjp-59809	156	32	drug	drug	NOUN
bjp-59809	156	33	accumulation	accumulation	NOUN
bjp-59809	156	34	,	,	PUNCT
bjp-59809	156	35	and	and	CCONJ
bjp-59809	156	36	stimulates	stimulate	VERB
bjp-59809	156	37	apoptosis	apoptosis	NOUN
bjp-59809	156	38	(	(	PUNCT
bjp-59809	156	39	xu	xu	INTJ
bjp-59809	156	40	et	et	PROPN
bjp-59809	156	41	al	al	PROPN
bjp-59809	156	42	.	.	PROPN
bjp-59809	156	43	,	,	PUNCT
bjp-59809	156	44	2016	2016	NUM
bjp-59809	156	45	)	)	PUNCT
bjp-59809	156	46	.	.	PUNCT
bjp-59809	157	1	although	although	SCONJ
bjp-59809	157	2	the	the	DET
bjp-59809	157	3	tumor	tumor	NOUN
bjp-59809	157	4	suppressive	suppressive	ADJ
bjp-59809	157	5	property	property	NOUN
bjp-59809	157	6	of	of	ADP
bjp-59809	157	7	sirt2	sirt2	PROPN
bjp-59809	157	8	is	be	AUX
bjp-59809	157	9	mentioned	mention	VERB
bjp-59809	157	10	,	,	PUNCT
bjp-59809	157	11	sirt2	sirt2	PROPN
bjp-59809	157	12	inhibitors	inhibitor	NOUN
bjp-59809	157	13	can	can	AUX
bjp-59809	157	14	cause	cause	VERB
bjp-59809	157	15	anti	anti	ADJ
bjp-59809	157	16	-	-	ADJ
bjp-59809	157	17	cancer	cancer	ADJ
bjp-59809	157	18	effects	effect	NOUN
bjp-59809	157	19	in	in	ADP
bjp-59809	157	20	various	various	ADJ
bjp-59809	157	21	studies	study	NOUN
bjp-59809	157	22	targeting	target	VERB
bjp-59809	157	23	sirt2	sirt2	PROPN
bjp-59809	157	24	pharmacologically	pharmacologically	ADV
bjp-59809	157	25	.	.	PUNCT
bjp-59809	158	1	agk2	agk2	PROPN
bjp-59809	158	2	,	,	PUNCT
bjp-59809	158	3	a	a	DET
bjp-59809	158	4	sirt2	sirt2	NOUN
bjp-59809	158	5	inhibitor	inhibitor	NOUN
bjp-59809	158	6	,	,	PUNCT
bjp-59809	158	7	arrests	arrest	VERB
bjp-59809	158	8	the	the	DET
bjp-59809	158	9	cell	cell	NOUN
bjp-59809	158	10	cycle	cycle	NOUN
bjp-59809	158	11	and	and	CCONJ
bjp-59809	158	12	inhibits	inhibit	VERB
bjp-59809	158	13	cell	cell	NOUN
bjp-59809	158	14	growth	growth	NOUN
bjp-59809	158	15	in	in	ADP
bjp-59809	158	16	cervical	cervical	ADJ
bjp-59809	158	17	cancer	cancer	NOUN
bjp-59809	158	18	cells	cell	NOUN
bjp-59809	158	19	with	with	ADP
bjp-59809	158	20	high	high	ADJ
bjp-59809	158	21	sirt2	sirt2	NOUN
bjp-59809	158	22	expression	expression	NOUN
bjp-59809	158	23	(	(	PUNCT
bjp-59809	158	24	singh	singh	PROPN
bjp-59809	158	25	et	et	PROPN
bjp-59809	158	26	al	al	PROPN
bjp-59809	158	27	.	.	PROPN
bjp-59809	158	28	,	,	PUNCT
bjp-59809	158	29	2015	2015	NUM
bjp-59809	158	30	)	)	PUNCT
bjp-59809	158	31	.	.	PUNCT
bjp-59809	159	1	tm	tm	PROPN
bjp-59809	159	2	,	,	PUNCT
bjp-59809	159	3	a	a	DET
bjp-59809	159	4	selective	selective	ADJ
bjp-59809	159	5	sirt2	sirt2	NOUN
bjp-59809	159	6	inhibitor	inhibitor	NOUN
bjp-59809	159	7	,	,	PUNCT
bjp-59809	159	8	exerts	exert	VERB
bjp-59809	159	9	an	an	DET
bjp-59809	159	10	anti	anti	ADJ
bjp-59809	159	11	-	-	ADJ
bjp-59809	159	12	cancer	cancer	ADJ
bjp-59809	159	13	effect	effect	NOUN
bjp-59809	159	14	through	through	ADP
bjp-59809	159	15	the	the	DET
bjp-59809	159	16	degradation	degradation	NOUN
bjp-59809	159	17	of	of	ADP
bjp-59809	159	18	c	c	NOUN
bjp-59809	159	19	-	-	PUNCT
bjp-59809	159	20	myc	myc	NOUN
bjp-59809	159	21	in	in	ADP
bjp-59809	159	22	breast	breast	NOUN
bjp-59809	159	23	cancer	cancer	NOUN
bjp-59809	159	24	cells	cell	NOUN
bjp-59809	159	25	(	(	PUNCT
bjp-59809	159	26	jing	je	VERB
bjp-59809	159	27	et	et	PROPN
bjp-59809	159	28	al	al	PROPN
bjp-59809	159	29	.	.	PROPN
bjp-59809	159	30	,	,	PUNCT
bjp-59809	159	31	2016	2016	NUM
bjp-59809	159	32	)	)	PUNCT
bjp-59809	159	33	.	.	PUNCT
bjp-59809	160	1	various	various	ADJ
bjp-59809	160	2	sirt1/2	sirt1/2	ADJ
bjp-59809	160	3	inhibitors	inhibitor	NOUN
bjp-59809	160	4	induce	induce	VERB
bjp-59809	160	5	p53	p53	NOUN
bjp-59809	160	6	acetylation	acetylation	NOUN
bjp-59809	160	7	and	and	CCONJ
bjp-59809	160	8	stimulate	stimulate	VERB
bjp-59809	160	9	cell	cell	NOUN
bjp-59809	160	10	death	death	NOUN
bjp-59809	160	11	in	in	ADP
bjp-59809	160	12	breast	breast	NOUN
bjp-59809	160	13	cancer	cancer	NOUN
bjp-59809	160	14	cells	cell	NOUN
bjp-59809	160	15	(	(	PUNCT
bjp-59809	160	16	peck	peck	VERB
bjp-59809	160	17	figure	figure	NOUN
bjp-59809	160	18	3	3	NUM
bjp-59809	160	19	:	:	PUNCT
bjp-59809	160	20	effect	effect	NOUN
bjp-59809	160	21	of	of	ADP
bjp-59809	160	22	ak-7	ak-7	ADP
bjp-59809	160	23	on	on	ADP
bjp-59809	160	24	caspase	caspase	PROPN
bjp-59809	160	25	pathway	pathway	NOUN
bjp-59809	160	26	mediated	mediate	VERB
bjp-59809	160	27	apoptosis	apoptosis	NOUN
bjp-59809	160	28	in	in	ADP
bjp-59809	160	29	u87	u87	ADJ
bjp-59809	160	30	gbm	gbm	NOUN
bjp-59809	160	31	cells	cell	NOUN
bjp-59809	160	32	.	.	PUNCT
bjp-59809	161	1	after	after	ADP
bjp-59809	161	2	treatment	treatment	NOUN
bjp-59809	161	3	with	with	ADP
bjp-59809	161	4	ak-7	ak-7	ADP
bjp-59809	161	5	(	(	PUNCT
bjp-59809	161	6	75	75	NUM
bjp-59809	161	7	and	and	CCONJ
bjp-59809	161	8	100	100	NUM
bjp-59809	161	9	µm	µm	NOUN
bjp-59809	161	10	)	)	PUNCT
bjp-59809	161	11	for	for	ADP
bjp-59809	161	12	48	48	NUM
bjp-59809	161	13	hours	hour	NOUN
bjp-59809	161	14	,	,	PUNCT
bjp-59809	161	15	mrna	mrna	NOUN
bjp-59809	161	16	expression	expression	NOUN
bjp-59809	161	17	levels	level	NOUN
bjp-59809	161	18	of	of	ADP
bjp-59809	161	19	apoptosis	apoptosis	NOUN
bjp-59809	161	20	-	-	PUNCT
bjp-59809	161	21	associated	associate	VERB
bjp-59809	161	22	genes	gene	NOUN
bjp-59809	161	23	were	be	AUX
bjp-59809	161	24	analyzed	analyze	VERB
bjp-59809	161	25	by	by	ADP
bjp-59809	161	26	qrt	qrt	NOUN
bjp-59809	161	27	-	-	PUNCT
bjp-59809	161	28	pcr	pcr	ADJ
bjp-59809	161	29	(	(	PUNCT
bjp-59809	161	30	a	a	NOUN
bjp-59809	161	31	)	)	PUNCT
bjp-59809	161	32	.	.	PUNCT
bjp-59809	162	1	the	the	DET
bjp-59809	162	2	effects	effect	NOUN
bjp-59809	162	3	of	of	ADP
bjp-59809	162	4	two	two	NUM
bjp-59809	162	5	different	different	ADJ
bjp-59809	162	6	concentrations	concentration	NOUN
bjp-59809	162	7	of	of	ADP
bjp-59809	162	8	ak-7	ak-7	ADP
bjp-59809	162	9	compared	compare	VERB
bjp-59809	162	10	to	to	ADP
bjp-59809	162	11	the	the	DET
bjp-59809	162	12	control	control	NOUN
bjp-59809	162	13	group	group	NOUN
bjp-59809	162	14	on	on	ADP
bjp-59809	162	15	caspase-3	caspase-3	NUM
bjp-59809	162	16	activity	activity	NOUN
bjp-59809	162	17	were	be	AUX
bjp-59809	162	18	performed	perform	VERB
bjp-59809	162	19	using	use	VERB
bjp-59809	162	20	the	the	DET
bjp-59809	162	21	caspase-3	caspase-3	NUM
bjp-59809	162	22	assay	assay	NOUN
bjp-59809	162	23	kit	kit	NOUN
bjp-59809	162	24	(	(	PUNCT
bjp-59809	162	25	ap<0.05	ap<0.05	NOUN
bjp-59809	162	26	,	,	PUNCT
bjp-59809	162	27	bp<0.01	bp<0.01	NOUN
bjp-59809	162	28	,	,	PUNCT
bjp-59809	162	29	cp<0.001	cp<0.001	NOUN
bjp-59809	162	30	)	)	PUNCT
bjp-59809	162	31	(	(	PUNCT
bjp-59809	162	32	b	b	X
bjp-59809	162	33	)	)	PUNCT
bjp-59809	162	34	a	a	DET
bjp-59809	162	35	b	b	NOUN
bjp-59809	162	36	f	f	X
bjp-59809	162	37	o	o	X
bjp-59809	162	38	ld	ld	PROPN
bjp-59809	162	39	c	c	PROPN
bjp-59809	162	40	h	h	NOUN
bjp-59809	162	41	a	a	DET
bjp-59809	162	42	n	n	CCONJ
bjp-59809	162	43	g	g	NOUN
bjp-59809	162	44	e	e	NOUN
bjp-59809	162	45	20	20	NUM
bjp-59809	162	46	0	0	NUM
bjp-59809	162	47	10	10	NUM
bjp-59809	162	48	15	15	NUM
bjp-59809	162	49	5	5	NUM
bjp-59809	162	50	5	5	NUM
bjp-59809	162	51	bax	bax	PROPN
bjp-59809	162	52	bcl2	bcl2	PROPN
bjp-59809	162	53	casp3	casp3	PROPN
bjp-59809	162	54	casp7	casp7	PROPN
bjp-59809	162	55	casp8	casp8	PROPN
bjp-59809	163	1	casp9	casp9	PROPN
bjp-59809	163	2	casp10	casp10	PROPN
bjp-59809	163	3	cycs	cycs	PROPN
bjp-59809	163	4	pparg	pparg	PROPN
bjp-59809	163	5	fas	fas	PROPN
bjp-59809	163	6	fadd	fadd	PROPN
bjp-59809	163	7	tnf	tnf	PROPN
bjp-59809	163	8	tnfr1	tnfr1	PROPN
bjp-59809	163	9	tnfr2	tnfr2	NOUN
bjp-59809	163	10	ak-7	ak-7	X
bjp-59809	163	11	0	0	NUM
bjp-59809	163	12	75	75	NUM
bjp-59809	163	13	100	100	NUM
bjp-59809	163	14	µm	µm	ADP
bjp-59809	163	15	c	c	NOUN
bjp-59809	163	16	a	a	PRON
bjp-59809	163	17	s	s	X
bjp-59809	163	18	p	p	NOUN
bjp-59809	163	19	a	a	DET
bjp-59809	163	20	s	s	X
bjp-59809	163	21	e	e	NOUN
bjp-59809	163	22	-3	-3	PUNCT
bjp-59809	163	23	a	a	DET
bjp-59809	163	24	c	c	NOUN
bjp-59809	163	25	ti	ti	NOUN
bjp-59809	163	26	v	v	ADP
bjp-59809	163	27	it	it	PRON
bjp-59809	164	1	y	y	PROPN
bjp-59809	164	2	(	(	PUNCT
bjp-59809	164	3	f	f	NOUN
bjp-59809	164	4	o	o	X
bjp-59809	164	5	ld	ld	PROPN
bjp-59809	164	6	c	c	PROPN
bjp-59809	164	7	h	h	NOUN
bjp-59809	164	8	a	a	PRON
bjp-59809	164	9	n	n	CCONJ
bjp-59809	164	10	g	g	NOUN
bjp-59809	164	11	e	e	NOUN
bjp-59809	164	12	)	)	PUNCT
bjp-59809	164	13	2	2	NUM
bjp-59809	164	14	3	3	NUM
bjp-59809	164	15	1	1	NUM
bjp-59809	164	16	0	0	NUM
bjp-59809	164	17	4	4	NUM
bjp-59809	164	18	a	a	DET
bjp-59809	164	19	a	a	DET
bjp-59809	164	20	a	a	DET
bjp-59809	164	21	a	a	DET
bjp-59809	164	22	a	a	DET
bjp-59809	164	23	a	a	DET
bjp-59809	164	24	a	a	DET
bjp-59809	164	25	a	a	DET
bjp-59809	164	26	a	a	DET
bjp-59809	164	27	a	a	DET
bjp-59809	164	28	a	a	DET
bjp-59809	164	29	a	a	DET
bjp-59809	164	30	a	a	DET
bjp-59809	164	31	a	a	DET
bjp-59809	164	32	a	a	DET
bjp-59809	164	33	a	a	DET
bjp-59809	164	34	a	a	DET
bjp-59809	164	35	a	a	DET
bjp-59809	164	36	a	a	DET
bjp-59809	164	37	b	b	NOUN
bjp-59809	164	38	c	c	NOUN
bjp-59809	164	39	c	c	PROPN
bjp-59809	164	40	bangladesh	bangladesh	PROPN
bjp-59809	164	41	j	j	PROPN
bjp-59809	164	42	pharmacol	pharmacol	PROPN
bjp-59809	164	43	2022	2022	NUM
bjp-59809	164	44	;	;	PUNCT
bjp-59809	164	45	17	17	NUM
bjp-59809	164	46	:	:	SYM
bjp-59809	164	47	42	42	NUM
bjp-59809	164	48	-	-	SYM
bjp-59809	164	49	50	50	NUM
bjp-59809	164	50	47	47	NUM
bjp-59809	164	51	et	et	NOUN
bjp-59809	164	52	al	al	PROPN
bjp-59809	164	53	.	.	PROPN
bjp-59809	164	54	,	,	PUNCT
bjp-59809	164	55	2010	2010	NUM
bjp-59809	164	56	)	)	PUNCT
bjp-59809	164	57	.	.	PUNCT
bjp-59809	165	1	ak-1	ak-1	NOUN
bjp-59809	165	2	induces	induce	VERB
bjp-59809	165	3	proteasomal	proteasomal	ADJ
bjp-59809	165	4	degradation	degradation	NOUN
bjp-59809	165	5	of	of	ADP
bjp-59809	165	6	transcription	transcription	NOUN
bjp-59809	165	7	factor	factor	NOUN
bjp-59809	165	8	snail	snail	NOUN
bjp-59809	165	9	and	and	CCONJ
bjp-59809	165	10	thus	thus	ADV
bjp-59809	165	11	arrests	arrest	VERB
bjp-59809	165	12	the	the	DET
bjp-59809	165	13	cell	cell	NOUN
bjp-59809	165	14	cycle	cycle	NOUN
bjp-59809	165	15	in	in	ADP
bjp-59809	165	16	colon	colon	NOUN
bjp-59809	165	17	cancer	cancer	NOUN
bjp-59809	165	18	cells	cell	NOUN
bjp-59809	165	19	(	(	PUNCT
bjp-59809	165	20	cheon	cheon	PROPN
bjp-59809	165	21	et	et	PROPN
bjp-59809	165	22	al	al	PROPN
bjp-59809	165	23	.	.	PROPN
bjp-59809	165	24	,	,	PUNCT
bjp-59809	165	25	2015	2015	NUM
bjp-59809	165	26	)	)	PUNCT
bjp-59809	165	27	.	.	PUNCT
bjp-59809	166	1	in	in	ADP
bjp-59809	166	2	this	this	DET
bjp-59809	166	3	study	study	NOUN
bjp-59809	166	4	,	,	PUNCT
bjp-59809	166	5	it	it	PRON
bjp-59809	166	6	was	be	AUX
bjp-59809	166	7	aimed	aim	VERB
bjp-59809	166	8	to	to	PART
bjp-59809	166	9	investigate	investigate	VERB
bjp-59809	166	10	the	the	DET
bjp-59809	166	11	possible	possible	ADJ
bjp-59809	166	12	anti	anti	ADJ
bjp-59809	166	13	-	-	ADJ
bjp-59809	166	14	cancer	cancer	ADJ
bjp-59809	166	15	effect	effect	NOUN
bjp-59809	166	16	of	of	ADP
bjp-59809	166	17	ak-7	ak-7	ADP
bjp-59809	166	18	in	in	ADP
bjp-59809	166	19	glioblastoma	glioblastoma	NOUN
bjp-59809	166	20	multiforme	multiforme	NOUN
bjp-59809	166	21	cells	cell	NOUN
bjp-59809	166	22	.	.	PUNCT
bjp-59809	167	1	although	although	SCONJ
bjp-59809	167	2	it	it	PRON
bjp-59809	167	3	is	be	AUX
bjp-59809	167	4	known	know	VERB
bjp-59809	167	5	that	that	SCONJ
bjp-59809	167	6	ak-7	ak-7	CCONJ
bjp-59809	167	7	inhibits	inhibit	VERB
bjp-59809	167	8	neurodegenerative	neurodegenerative	ADJ
bjp-59809	167	9	processes	process	NOUN
bjp-59809	167	10	and	and	CCONJ
bjp-59809	167	11	has	have	VERB
bjp-59809	167	12	a	a	DET
bjp-59809	167	13	neuroprotective	neuroprotective	ADJ
bjp-59809	167	14	effect	effect	NOUN
bjp-59809	167	15	,	,	PUNCT
bjp-59809	167	16	there	there	PRON
bjp-59809	167	17	is	be	VERB
bjp-59809	167	18	no	no	DET
bjp-59809	167	19	information	information	NOUN
bjp-59809	167	20	about	about	ADP
bjp-59809	167	21	the	the	DET
bjp-59809	167	22	anti	anti	ADJ
bjp-59809	167	23	-	-	ADJ
bjp-59809	167	24	cancer	cancer	ADJ
bjp-59809	167	25	activity	activity	NOUN
bjp-59809	167	26	of	of	ADP
bjp-59809	167	27	ak-7	ak-7	PROPN
bjp-59809	167	28	(	(	PUNCT
bjp-59809	167	29	chopra	chopra	PROPN
bjp-59809	167	30	et	et	PROPN
bjp-59809	167	31	al	al	PROPN
bjp-59809	167	32	.	.	PROPN
bjp-59809	167	33	,	,	PUNCT
bjp-59809	167	34	2012	2012	NUM
bjp-59809	167	35	;	;	PUNCT
bjp-59809	167	36	chen	chen	PROPN
bjp-59809	167	37	et	et	PROPN
bjp-59809	167	38	al	al	PROPN
bjp-59809	167	39	.	.	PROPN
bjp-59809	167	40	,	,	PUNCT
bjp-59809	167	41	2015	2015	NUM
bjp-59809	167	42	;	;	PUNCT
bjp-59809	167	43	biella	biella	PROPN
bjp-59809	167	44	et	et	PROPN
bjp-59809	167	45	al	al	PROPN
bjp-59809	167	46	.	.	PROPN
bjp-59809	167	47	,	,	PUNCT
bjp-59809	167	48	2016	2016	NUM
bjp-59809	167	49	)	)	PUNCT
bjp-59809	167	50	.	.	PUNCT
bjp-59809	168	1	to	to	PART
bjp-59809	168	2	investigate	investigate	VERB
bjp-59809	168	3	the	the	DET
bjp-59809	168	4	possible	possible	ADJ
bjp-59809	168	5	anticancer	anticancer	NOUN
bjp-59809	168	6	effect	effect	NOUN
bjp-59809	168	7	of	of	ADP
bjp-59809	168	8	ak-7	ak-7	ADP
bjp-59809	168	9	in	in	ADP
bjp-59809	168	10	glioblastoma	glioblastoma	NOUN
bjp-59809	168	11	multiforme	multiforme	NOUN
bjp-59809	168	12	cells	cell	NOUN
bjp-59809	168	13	,	,	PUNCT
bjp-59809	168	14	we	we	PRON
bjp-59809	168	15	first	first	ADV
bjp-59809	168	16	performed	perform	VERB
bjp-59809	168	17	cytotoxicity	cytotoxicity	NOUN
bjp-59809	168	18	analysis	analysis	NOUN
bjp-59809	168	19	.	.	PUNCT
bjp-59809	169	1	according	accord	VERB
bjp-59809	169	2	to	to	ADP
bjp-59809	169	3	the	the	DET
bjp-59809	169	4	cytotoxicity	cytotoxicity	NOUN
bjp-59809	169	5	analysis	analysis	NOUN
bjp-59809	169	6	results	result	NOUN
bjp-59809	169	7	,	,	PUNCT
bjp-59809	169	8	ak-7	ak-7	CCONJ
bjp-59809	169	9	inhibited	inhibited	ADJ
bjp-59809	169	10	cell	cell	NOUN
bjp-59809	169	11	proliferation	proliferation	NOUN
bjp-59809	169	12	in	in	ADP
bjp-59809	169	13	glioblastoma	glioblastoma	NOUN
bjp-59809	169	14	multiforme	multiforme	NOUN
bjp-59809	169	15	cells	cell	NOUN
bjp-59809	169	16	in	in	ADP
bjp-59809	169	17	a	a	DET
bjp-59809	169	18	dose	dose	NOUN
bjp-59809	169	19	and	and	CCONJ
bjp-59809	169	20	time	time	NOUN
bjp-59809	169	21	-	-	PUNCT
bjp-59809	169	22	dependent	dependent	ADJ
bjp-59809	169	23	manner	manner	NOUN
bjp-59809	169	24	.	.	PUNCT
bjp-59809	170	1	the	the	DET
bjp-59809	170	2	ic50	ic50	PROPN
bjp-59809	170	3	dose	dose	NOUN
bjp-59809	170	4	of	of	ADP
bjp-59809	170	5	ak-7	ak-7	ADP
bjp-59809	170	6	in	in	ADP
bjp-59809	170	7	u87	u87	ADJ
bjp-59809	170	8	cells	cell	NOUN
bjp-59809	170	9	was	be	AUX
bjp-59809	170	10	found	find	VERB
bjp-59809	170	11	to	to	PART
bjp-59809	170	12	be	be	AUX
bjp-59809	170	13	107.0	107.0	NUM
bjp-59809	170	14	µm	µm	NOUN
bjp-59809	170	15	for	for	ADP
bjp-59809	170	16	48	48	NUM
bjp-59809	170	17	hours	hour	NOUN
bjp-59809	170	18	.	.	PUNCT
bjp-59809	171	1	in	in	ADP
bjp-59809	171	2	subsequent	subsequent	ADJ
bjp-59809	171	3	analyzes	analyze	NOUN
bjp-59809	171	4	,	,	PUNCT
bjp-59809	171	5	u87	u87	ADJ
bjp-59809	171	6	cells	cell	NOUN
bjp-59809	171	7	were	be	AUX
bjp-59809	171	8	treated	treat	VERB
bjp-59809	171	9	with	with	ADP
bjp-59809	171	10	75	75	NUM
bjp-59809	171	11	µm	µm	NOUN
bjp-59809	171	12	and	and	CCONJ
bjp-59809	171	13	100	100	NUM
bjp-59809	171	14	µm	µm	NOUN
bjp-59809	171	15	ak-7	ak-7	ADV
bjp-59809	171	16	for	for	ADP
bjp-59809	171	17	48	48	NUM
bjp-59809	171	18	hours	hour	NOUN
bjp-59809	171	19	to	to	PART
bjp-59809	171	20	reveal	reveal	VERB
bjp-59809	171	21	whether	whether	SCONJ
bjp-59809	171	22	there	there	PRON
bjp-59809	171	23	was	be	VERB
bjp-59809	171	24	a	a	DET
bjp-59809	171	25	dose	dose	NOUN
bjp-59809	171	26	-	-	PUNCT
bjp-59809	171	27	dependent	dependent	ADJ
bjp-59809	171	28	effect	effect	NOUN
bjp-59809	171	29	of	of	ADP
bjp-59809	171	30	ak-7	ak-7	PROPN
bjp-59809	171	31	.	.	PUNCT
bjp-59809	172	1	the	the	DET
bjp-59809	172	2	effect	effect	NOUN
bjp-59809	172	3	of	of	ADP
bjp-59809	172	4	ak-7	ak-7	ADP
bjp-59809	172	5	on	on	ADP
bjp-59809	172	6	cell	cell	NOUN
bjp-59809	172	7	proliferation	proliferation	NOUN
bjp-59809	172	8	was	be	AUX
bjp-59809	172	9	also	also	ADV
bjp-59809	172	10	evaluated	evaluate	VERB
bjp-59809	172	11	by	by	ADP
bjp-59809	172	12	colony	colony	NOUN
bjp-59809	172	13	formation	formation	NOUN
bjp-59809	172	14	analysis	analysis	NOUN
bjp-59809	172	15	and	and	CCONJ
bjp-59809	172	16	it	it	PRON
bjp-59809	172	17	was	be	AUX
bjp-59809	172	18	observed	observe	VERB
bjp-59809	172	19	that	that	SCONJ
bjp-59809	172	20	treatment	treatment	NOUN
bjp-59809	172	21	with	with	ADP
bjp-59809	172	22	75	75	NUM
bjp-59809	172	23	µm	µm	NOUN
bjp-59809	172	24	and	and	CCONJ
bjp-59809	172	25	100	100	NUM
bjp-59809	172	26	µm	µm	NOUN
bjp-59809	172	27	ak-7	ak-7	CCONJ
bjp-59809	172	28	inhibited	inhibit	VERB
bjp-59809	172	29	the	the	DET
bjp-59809	172	30	colony	colony	NOUN
bjp-59809	172	31	forming	form	VERB
bjp-59809	172	32	capacity	capacity	NOUN
bjp-59809	172	33	of	of	ADP
bjp-59809	172	34	u87	u87	ADJ
bjp-59809	172	35	cells	cell	NOUN
bjp-59809	172	36	.	.	PUNCT
bjp-59809	173	1	in	in	ADP
bjp-59809	173	2	this	this	DET
bjp-59809	173	3	study	study	NOUN
bjp-59809	173	4	,	,	PUNCT
bjp-59809	173	5	the	the	DET
bjp-59809	173	6	possible	possible	ADJ
bjp-59809	173	7	anti	anti	ADJ
bjp-59809	173	8	-	-	ADJ
bjp-59809	173	9	cancer	cancer	ADJ
bjp-59809	173	10	activity	activity	NOUN
bjp-59809	173	11	of	of	ADP
bjp-59809	173	12	ak-7	ak-7	ADP
bjp-59809	173	13	in	in	ADP
bjp-59809	173	14	glioblastoma	glioblastoma	NOUN
bjp-59809	173	15	multiforme	multiforme	NOUN
bjp-59809	173	16	cells	cell	NOUN
bjp-59809	173	17	was	be	AUX
bjp-59809	173	18	evaluated	evaluate	VERB
bjp-59809	173	19	with	with	ADP
bjp-59809	173	20	various	various	ADJ
bjp-59809	173	21	analyzes	analyze	NOUN
bjp-59809	173	22	to	to	PART
bjp-59809	173	23	determine	determine	VERB
bjp-59809	173	24	apoptosis	apoptosis	NOUN
bjp-59809	173	25	.	.	PUNCT
bjp-59809	174	1	according	accord	VERB
bjp-59809	174	2	to	to	ADP
bjp-59809	174	3	annexin	annexin	NOUN
bjp-59809	174	4	v	v	ADP
bjp-59809	174	5	analysis	analysis	NOUN
bjp-59809	174	6	results	result	NOUN
bjp-59809	174	7	,	,	PUNCT
bjp-59809	174	8	treatment	treatment	NOUN
bjp-59809	174	9	with	with	ADP
bjp-59809	174	10	75	75	NUM
bjp-59809	174	11	µm	µm	NOUN
bjp-59809	174	12	and	and	CCONJ
bjp-59809	174	13	100	100	NUM
bjp-59809	174	14	µm	µm	NOUN
bjp-59809	174	15	ak-7	ak-7	ADV
bjp-59809	174	16	significantly	significantly	ADV
bjp-59809	174	17	increased	increase	VERB
bjp-59809	174	18	the	the	DET
bjp-59809	174	19	%	%	NOUN
bjp-59809	174	20	apoptosis	apoptosis	NOUN
bjp-59809	174	21	rate	rate	NOUN
bjp-59809	174	22	in	in	ADP
bjp-59809	174	23	glioblastoma	glioblastoma	NOUN
bjp-59809	174	24	multiforme	multiforme	NOUN
bjp-59809	174	25	cells	cell	NOUN
bjp-59809	174	26	compared	compare	VERB
bjp-59809	174	27	to	to	ADP
bjp-59809	174	28	the	the	DET
bjp-59809	174	29	control	control	NOUN
bjp-59809	174	30	group	group	NOUN
bjp-59809	174	31	.	.	PUNCT
bjp-59809	175	1	in	in	ADP
bjp-59809	175	2	addition	addition	NOUN
bjp-59809	175	3	,	,	PUNCT
bjp-59809	175	4	the	the	DET
bjp-59809	175	5	apoptosis	apoptosis	NOUN
bjp-59809	175	6	-	-	PUNCT
bjp-59809	175	7	inducing	induce	VERB
bjp-59809	175	8	effect	effect	NOUN
bjp-59809	175	9	of	of	ADP
bjp-59809	175	10	ak-7	ak-7	CCONJ
bjp-59809	175	11	increased	increase	VERB
bjp-59809	175	12	in	in	ADP
bjp-59809	175	13	a	a	DET
bjp-59809	175	14	dose	dose	NOUN
bjp-59809	175	15	-	-	PUNCT
bjp-59809	175	16	dependent	dependent	ADJ
bjp-59809	175	17	manner	manner	NOUN
bjp-59809	175	18	.	.	PUNCT
bjp-59809	176	1	apoptosis	apoptosis	NOUN
bjp-59809	176	2	is	be	AUX
bjp-59809	176	3	characterized	characterize	VERB
bjp-59809	176	4	by	by	ADP
bjp-59809	176	5	a	a	DET
bjp-59809	176	6	series	series	NOUN
bjp-59809	176	7	of	of	ADP
bjp-59809	176	8	typical	typical	ADJ
bjp-59809	176	9	morphological	morphological	ADJ
bjp-59809	176	10	changes	change	NOUN
bjp-59809	176	11	such	such	ADJ
bjp-59809	176	12	as	as	ADP
bjp-59809	176	13	shrinkage	shrinkage	NOUN
bjp-59809	176	14	of	of	ADP
bjp-59809	176	15	cell	cell	NOUN
bjp-59809	176	16	and	and	CCONJ
bjp-59809	176	17	nucleus	nucleus	NOUN
bjp-59809	176	18	,	,	PUNCT
bjp-59809	176	19	chromatin	chromatin	NOUN
bjp-59809	176	20	condensation	condensation	NOUN
bjp-59809	176	21	,	,	PUNCT
bjp-59809	176	22	and	and	CCONJ
bjp-59809	176	23	formation	formation	NOUN
bjp-59809	176	24	of	of	ADP
bjp-59809	176	25	apoptotic	apoptotic	ADJ
bjp-59809	176	26	bodies	body	NOUN
bjp-59809	176	27	.	.	PUNCT
bjp-59809	177	1	at	at	ADP
bjp-59809	177	2	this	this	DET
bjp-59809	177	3	stage	stage	NOUN
bjp-59809	177	4	,	,	PUNCT
bjp-59809	177	5	fragmentation	fragmentation	NOUN
bjp-59809	177	6	of	of	ADP
bjp-59809	177	7	chromosomal	chromosomal	ADJ
bjp-59809	177	8	dna	dna	NOUN
bjp-59809	177	9	into	into	ADP
bjp-59809	177	10	oligonucleosome	oligonucleosome	NOUN
bjp-59809	177	11	-	-	PUNCT
bjp-59809	177	12	sized	sized	ADJ
bjp-59809	177	13	fragments	fragment	NOUN
bjp-59809	177	14	is	be	AUX
bjp-59809	177	15	also	also	ADV
bjp-59809	177	16	one	one	NUM
bjp-59809	177	17	of	of	ADP
bjp-59809	177	18	the	the	DET
bjp-59809	177	19	important	important	ADJ
bjp-59809	177	20	markers	marker	NOUN
bjp-59809	177	21	of	of	ADP
bjp-59809	177	22	apoptosis	apoptosis	NOUN
bjp-59809	177	23	(	(	PUNCT
bjp-59809	177	24	elmore	elmore	NOUN
bjp-59809	177	25	,	,	PUNCT
bjp-59809	177	26	2007	2007	NUM
bjp-59809	177	27	;	;	PUNCT
bjp-59809	177	28	zhang	zhang	PROPN
bjp-59809	177	29	and	and	CCONJ
bjp-59809	177	30	xu	xu	PROPN
bjp-59809	177	31	,	,	PUNCT
bjp-59809	177	32	2000	2000	NUM
bjp-59809	177	33	)	)	PUNCT
bjp-59809	177	34	.	.	PUNCT
bjp-59809	178	1	according	accord	VERB
bjp-59809	178	2	to	to	ADP
bjp-59809	178	3	dna	dna	PROPN
bjp-59809	178	4	fragmentation	fragmentation	NOUN
bjp-59809	178	5	analysis	analysis	NOUN
bjp-59809	178	6	results	result	NOUN
bjp-59809	178	7	,	,	PUNCT
bjp-59809	178	8	dna	dna	NOUN
bjp-59809	178	9	fragmentation	fragmentation	NOUN
bjp-59809	178	10	was	be	AUX
bjp-59809	178	11	induced	induce	VERB
bjp-59809	178	12	in	in	ADP
bjp-59809	178	13	u87	u87	ADJ
bjp-59809	178	14	cells	cell	NOUN
bjp-59809	178	15	after	after	ADP
bjp-59809	178	16	treatment	treatment	NOUN
bjp-59809	178	17	with	with	ADP
bjp-59809	178	18	75	75	NUM
bjp-59809	178	19	and	and	CCONJ
bjp-59809	178	20	100	100	NUM
bjp-59809	178	21	µm	µm	ADP
bjp-59809	178	22	ak-7	ak-7	PROPN
bjp-59809	178	23	.	.	PUNCT
bjp-59809	179	1	it	it	PRON
bjp-59809	179	2	was	be	AUX
bjp-59809	179	3	also	also	ADV
bjp-59809	179	4	observed	observe	VERB
bjp-59809	179	5	that	that	SCONJ
bjp-59809	179	6	dna	dna	PROPN
bjp-59809	179	7	fragmentation	fragmentation	NOUN
bjp-59809	179	8	increased	increase	VERB
bjp-59809	179	9	depending	depend	VERB
bjp-59809	179	10	on	on	ADP
bjp-59809	179	11	the	the	DET
bjp-59809	179	12	dose	dose	NOUN
bjp-59809	179	13	of	of	ADP
bjp-59809	179	14	ak-7	ak-7	PROPN
bjp-59809	179	15	.	.	PUNCT
bjp-59809	180	1	caspases	caspase	NOUN
bjp-59809	180	2	are	be	AUX
bjp-59809	180	3	at	at	ADP
bjp-59809	180	4	the	the	DET
bjp-59809	180	5	center	center	NOUN
bjp-59809	180	6	of	of	ADP
bjp-59809	180	7	the	the	DET
bjp-59809	180	8	apoptosis	apoptosis	NOUN
bjp-59809	180	9	mechanism	mechanism	NOUN
bjp-59809	180	10	in	in	ADP
bjp-59809	180	11	the	the	DET
bjp-59809	180	12	cell	cell	NOUN
bjp-59809	180	13	,	,	PUNCT
bjp-59809	180	14	and	and	CCONJ
bjp-59809	180	15	apoptosis	apoptosis	NOUN
bjp-59809	180	16	occurs	occur	VERB
bjp-59809	180	17	in	in	ADP
bjp-59809	180	18	two	two	NUM
bjp-59809	180	19	pathways	pathway	NOUN
bjp-59809	180	20	,	,	PUNCT
bjp-59809	180	21	in	in	ADP
bjp-59809	180	22	which	which	PRON
bjp-59809	180	23	a	a	DET
bjp-59809	180	24	large	large	ADJ
bjp-59809	180	25	number	number	NOUN
bjp-59809	180	26	of	of	ADP
bjp-59809	180	27	molecules	molecule	NOUN
bjp-59809	180	28	are	be	AUX
bjp-59809	180	29	involved	involve	VERB
bjp-59809	180	30	:	:	PUNCT
bjp-59809	180	31	the	the	DET
bjp-59809	180	32	extrinsic	extrinsic	ADJ
bjp-59809	180	33	pathway	pathway	NOUN
bjp-59809	180	34	and	and	CCONJ
bjp-59809	180	35	the	the	DET
bjp-59809	180	36	intrinsic	intrinsic	ADJ
bjp-59809	180	37	pathway	pathway	NOUN
bjp-59809	180	38	.	.	PUNCT
bjp-59809	181	1	the	the	DET
bjp-59809	181	2	extrinsic	extrinsic	ADJ
bjp-59809	181	3	pathway	pathway	NOUN
bjp-59809	181	4	is	be	AUX
bjp-59809	181	5	initiated	initiate	VERB
bjp-59809	181	6	by	by	ADP
bjp-59809	181	7	the	the	DET
bjp-59809	181	8	interaction	interaction	NOUN
bjp-59809	181	9	of	of	ADP
bjp-59809	181	10	various	various	ADJ
bjp-59809	181	11	death	death	NOUN
bjp-59809	181	12	receptors	receptor	NOUN
bjp-59809	181	13	with	with	ADP
bjp-59809	181	14	their	their	PRON
bjp-59809	181	15	ligands	ligand	NOUN
bjp-59809	181	16	.	.	PUNCT
bjp-59809	182	1	then	then	ADV
bjp-59809	182	2	,	,	PUNCT
bjp-59809	182	3	the	the	DET
bjp-59809	182	4	deathinducing	deathinduce	VERB
bjp-59809	182	5	signaling	signal	VERB
bjp-59809	182	6	complex	complex	NOUN
bjp-59809	182	7	(	(	PUNCT
bjp-59809	182	8	disc	disc	NOUN
bjp-59809	182	9	)	)	PUNCT
bjp-59809	182	10	is	be	AUX
bjp-59809	182	11	formed	form	VERB
bjp-59809	182	12	with	with	ADP
bjp-59809	182	13	adapter	adapter	NOUN
bjp-59809	182	14	proteins	protein	NOUN
bjp-59809	182	15	such	such	ADJ
bjp-59809	182	16	as	as	ADP
bjp-59809	182	17	tnf	tnf	PROPN
bjp-59809	182	18	receptor	receptor	NOUN
bjp-59809	182	19	-	-	PUNCT
bjp-59809	182	20	associated	associate	VERB
bjp-59809	182	21	death	death	NOUN
bjp-59809	182	22	domain	domain	NOUN
bjp-59809	182	23	(	(	PUNCT
bjp-59809	182	24	tradd	tradd	NOUN
bjp-59809	182	25	)	)	PUNCT
bjp-59809	182	26	and	and	CCONJ
bjp-59809	182	27	fas	fas	ADJ
bjp-59809	182	28	-	-	PUNCT
bjp-59809	182	29	associated	associate	VERB
bjp-59809	182	30	death	death	NOUN
bjp-59809	182	31	domain	domain	NOUN
bjp-59809	182	32	(	(	PUNCT
bjp-59809	182	33	fadd	fadd	NOUN
bjp-59809	182	34	)	)	PUNCT
bjp-59809	182	35	,	,	PUNCT
bjp-59809	182	36	procaspases-8	procaspases-8	NUM
bjp-59809	182	37	and	and	CCONJ
bjp-59809	182	38	-10	-10	PROPN
bjp-59809	182	39	.	.	PUNCT
bjp-59809	183	1	this	this	DET
bjp-59809	183	2	formation	formation	NOUN
bjp-59809	183	3	causes	cause	VERB
bjp-59809	183	4	activation	activation	NOUN
bjp-59809	183	5	of	of	ADP
bjp-59809	183	6	caspase-8	caspase-8	NOUN
bjp-59809	183	7	and	and	CCONJ
bjp-59809	183	8	10	10	NUM
bjp-59809	183	9	,	,	PUNCT
bjp-59809	183	10	and	and	CCONJ
bjp-59809	183	11	then	then	ADV
bjp-59809	183	12	apoptosis	apoptosis	NOUN
bjp-59809	183	13	is	be	AUX
bjp-59809	183	14	induced	induce	VERB
bjp-59809	183	15	by	by	ADP
bjp-59809	183	16	activation	activation	NOUN
bjp-59809	183	17	of	of	ADP
bjp-59809	183	18	caspase-3	caspase-3	NUM
bjp-59809	183	19	,	,	PUNCT
bjp-59809	183	20	-6	-6	PUNCT
bjp-59809	183	21	and	and	CCONJ
bjp-59809	183	22	-7	-7	INTJ
bjp-59809	183	23	(	(	PUNCT
bjp-59809	183	24	ashkenazi	ashkenazi	ADJ
bjp-59809	183	25	,	,	PUNCT
bjp-59809	183	26	2008	2008	NUM
bjp-59809	183	27	;	;	PUNCT
bjp-59809	183	28	wong	wong	PROPN
bjp-59809	183	29	,	,	PUNCT
bjp-59809	183	30	2011	2011	NUM
bjp-59809	183	31	)	)	PUNCT
bjp-59809	183	32	.	.	PUNCT
bjp-59809	184	1	in	in	ADP
bjp-59809	184	2	the	the	DET
bjp-59809	184	3	intrinsic	intrinsic	ADJ
bjp-59809	184	4	pathway	pathway	NOUN
bjp-59809	184	5	,	,	PUNCT
bjp-59809	184	6	bcl-2	bcl-2	ADJ
bjp-59809	184	7	family	family	NOUN
bjp-59809	184	8	,	,	PUNCT
bjp-59809	184	9	which	which	PRON
bjp-59809	184	10	consists	consist	VERB
bjp-59809	184	11	of	of	ADP
bjp-59809	184	12	proapoptotic	proapoptotic	ADJ
bjp-59809	184	13	and	and	CCONJ
bjp-59809	184	14	antiapoptotic	antiapoptotic	ADJ
bjp-59809	184	15	members	member	NOUN
bjp-59809	184	16	,	,	PUNCT
bjp-59809	184	17	is	be	AUX
bjp-59809	184	18	involved	involve	VERB
bjp-59809	184	19	and	and	CCONJ
bjp-59809	184	20	especially	especially	ADV
bjp-59809	184	21	the	the	DET
bjp-59809	184	22	balance	balance	NOUN
bjp-59809	184	23	between	between	ADP
bjp-59809	184	24	bcl-2	bcl-2	PUNCT
bjp-59809	184	25	and	and	CCONJ
bjp-59809	184	26	bax	bax	NOUN
bjp-59809	184	27	is	be	AUX
bjp-59809	184	28	determinant	determinant	ADJ
bjp-59809	184	29	in	in	ADP
bjp-59809	184	30	the	the	DET
bjp-59809	184	31	release	release	NOUN
bjp-59809	184	32	of	of	ADP
bjp-59809	184	33	cytochrome	cytochrome	PROPN
bjp-59809	184	34	c	c	NOUN
bjp-59809	184	35	from	from	ADP
bjp-59809	184	36	mitochondria	mitochondria	NOUN
bjp-59809	184	37	to	to	ADP
bjp-59809	184	38	the	the	DET
bjp-59809	184	39	cytoplasm	cytoplasm	NOUN
bjp-59809	184	40	.	.	PUNCT
bjp-59809	185	1	cytochrome	cytochrome	PROPN
bjp-59809	185	2	c	c	PROPN
bjp-59809	185	3	released	release	VERB
bjp-59809	185	4	into	into	ADP
bjp-59809	185	5	the	the	DET
bjp-59809	185	6	cytoplasm	cytoplasm	NOUN
bjp-59809	185	7	interacts	interact	VERB
bjp-59809	185	8	with	with	ADP
bjp-59809	185	9	apaf-1	apaf-1	NUM
bjp-59809	185	10	and	and	CCONJ
bjp-59809	185	11	caspase-9	caspase-9	PROPN
bjp-59809	185	12	is	be	AUX
bjp-59809	185	13	activated	activate	VERB
bjp-59809	185	14	.	.	PUNCT
bjp-59809	186	1	and	and	CCONJ
bjp-59809	186	2	,	,	PUNCT
bjp-59809	186	3	apoptosis	apoptosis	NOUN
bjp-59809	186	4	is	be	AUX
bjp-59809	186	5	induced	induce	VERB
bjp-59809	186	6	by	by	ADP
bjp-59809	186	7	the	the	DET
bjp-59809	186	8	activation	activation	NOUN
bjp-59809	186	9	of	of	ADP
bjp-59809	186	10	caspase-3	caspase-3	NUM
bjp-59809	186	11	by	by	ADP
bjp-59809	186	12	active	active	ADJ
bjp-59809	186	13	caspase-9	caspase-9	PROPN
bjp-59809	186	14	(	(	PUNCT
bjp-59809	186	15	elmore	elmore	NOUN
bjp-59809	186	16	,	,	PUNCT
bjp-59809	186	17	2007	2007	NUM
bjp-59809	186	18	;	;	PUNCT
bjp-59809	186	19	inoue	inoue	PROPN
bjp-59809	186	20	et	et	PROPN
bjp-59809	186	21	al	al	PROPN
bjp-59809	186	22	.	.	PROPN
bjp-59809	186	23	,	,	PUNCT
bjp-59809	186	24	2009	2009	NUM
bjp-59809	186	25	)	)	PUNCT
bjp-59809	186	26	.	.	PUNCT
bjp-59809	187	1	in	in	ADP
bjp-59809	187	2	this	this	DET
bjp-59809	187	3	study	study	NOUN
bjp-59809	187	4	,	,	PUNCT
bjp-59809	187	5	the	the	DET
bjp-59809	187	6	anti	anti	ADJ
bjp-59809	187	7	-	-	ADJ
bjp-59809	187	8	cancer	cancer	ADJ
bjp-59809	187	9	effect	effect	NOUN
bjp-59809	187	10	of	of	ADP
bjp-59809	187	11	ak-7	ak-7	ADV
bjp-59809	187	12	was	be	AUX
bjp-59809	187	13	evaluated	evaluate	VERB
bjp-59809	187	14	at	at	ADP
bjp-59809	187	15	the	the	DET
bjp-59809	187	16	molecular	molecular	ADJ
bjp-59809	187	17	level	level	NOUN
bjp-59809	187	18	by	by	ADP
bjp-59809	187	19	analyzing	analyze	VERB
bjp-59809	187	20	the	the	DET
bjp-59809	187	21	expression	expression	NOUN
bjp-59809	187	22	levels	level	NOUN
bjp-59809	187	23	of	of	ADP
bjp-59809	187	24	genes	gene	NOUN
bjp-59809	187	25	associated	associate	VERB
bjp-59809	187	26	with	with	ADP
bjp-59809	187	27	extrinsic	extrinsic	ADJ
bjp-59809	187	28	and	and	CCONJ
bjp-59809	187	29	intrinsic	intrinsic	ADJ
bjp-59809	187	30	pathways	pathway	NOUN
bjp-59809	187	31	of	of	ADP
bjp-59809	187	32	apoptosis	apoptosis	NOUN
bjp-59809	187	33	.	.	PUNCT
bjp-59809	188	1	for	for	ADP
bjp-59809	188	2	this	this	DET
bjp-59809	188	3	purpose	purpose	NOUN
bjp-59809	188	4	,	,	PUNCT
bjp-59809	188	5	expression	expression	NOUN
bjp-59809	188	6	levels	level	NOUN
bjp-59809	188	7	of	of	ADP
bjp-59809	188	8	casp8	casp8	PROPN
bjp-59809	188	9	,	,	PUNCT
bjp-59809	188	10	casp10	casp10	PROPN
bjp-59809	188	11	,	,	PUNCT
bjp-59809	188	12	fas	fas	ADJ
bjp-59809	188	13	,	,	PUNCT
bjp-59809	188	14	fadd	fadd	NOUN
bjp-59809	188	15	,	,	PUNCT
bjp-59809	188	16	tnf	tnf	PROPN
bjp-59809	188	17	,	,	PUNCT
bjp-59809	188	18	tnfr1	tnfr1	NOUN
bjp-59809	188	19	and	and	CCONJ
bjp-59809	188	20	tnfr2	tnfr2	NOUN
bjp-59809	188	21	genes	gene	NOUN
bjp-59809	188	22	associated	associate	VERB
bjp-59809	188	23	with	with	ADP
bjp-59809	188	24	the	the	DET
bjp-59809	188	25	extrinsic	extrinsic	ADJ
bjp-59809	188	26	pathway	pathway	NOUN
bjp-59809	188	27	;	;	PUNCT
bjp-59809	188	28	bax	bax	PROPN
bjp-59809	188	29	,	,	PUNCT
bjp-59809	188	30	bcl2	bcl2	PROPN
bjp-59809	188	31	,	,	PUNCT
bjp-59809	188	32	casp7	casp7	PROPN
bjp-59809	188	33	,	,	PUNCT
bjp-59809	188	34	cycs	cycs	PROPN
bjp-59809	188	35	and	and	CCONJ
bjp-59809	188	36	pparg	pparg	NOUN
bjp-59809	188	37	genes	gene	NOUN
bjp-59809	188	38	associated	associate	VERB
bjp-59809	188	39	with	with	ADP
bjp-59809	188	40	the	the	DET
bjp-59809	188	41	intrinsic	intrinsic	ADJ
bjp-59809	188	42	pathway	pathway	NOUN
bjp-59809	188	43	,	,	PUNCT
bjp-59809	188	44	and	and	CCONJ
bjp-59809	188	45	casp3	casp3	NOUN
bjp-59809	188	46	gene	gene	NOUN
bjp-59809	188	47	associated	associate	VERB
bjp-59809	188	48	with	with	ADP
bjp-59809	188	49	both	both	DET
bjp-59809	188	50	pathways	pathway	NOUN
bjp-59809	188	51	were	be	AUX
bjp-59809	188	52	determined	determine	VERB
bjp-59809	188	53	in	in	ADP
bjp-59809	188	54	qrt	qrt	ADJ
bjp-59809	188	55	-pcr	-pcr	NUM
bjp-59809	188	56	analysis	analysis	NOUN
bjp-59809	188	57	after	after	ADP
bjp-59809	188	58	treatment	treatment	NOUN
bjp-59809	188	59	with	with	ADP
bjp-59809	188	60	ak-7	ak-7	PROPN
bjp-59809	188	61	.	.	PUNCT
bjp-59809	189	1	according	accord	VERB
bjp-59809	189	2	to	to	ADP
bjp-59809	189	3	qrt	qrt	ADJ
bjp-59809	189	4	-	-	PUNCT
bjp-59809	189	5	pcr	pcr	ADJ
bjp-59809	189	6	results	result	NOUN
bjp-59809	189	7	,	,	PUNCT
bjp-59809	189	8	ak-7	ak-7	ADV
bjp-59809	189	9	significantly	significantly	ADV
bjp-59809	189	10	increased	increase	VERB
bjp-59809	189	11	the	the	DET
bjp-59809	189	12	expression	expression	NOUN
bjp-59809	189	13	of	of	ADP
bjp-59809	189	14	both	both	CCONJ
bjp-59809	189	15	extrinsic	extrinsic	ADJ
bjp-59809	189	16	and	and	CCONJ
bjp-59809	189	17	intrinsic	intrinsic	ADJ
bjp-59809	189	18	pathway	pathway	NOUN
bjp-59809	189	19	-	-	PUNCT
bjp-59809	189	20	related	relate	VERB
bjp-59809	189	21	genes	gene	NOUN
bjp-59809	189	22	in	in	ADP
bjp-59809	189	23	glioblastoma	glioblastoma	NOUN
bjp-59809	189	24	multiforme	multiforme	NOUN
bjp-59809	189	25	cells	cell	NOUN
bjp-59809	189	26	.	.	PUNCT
bjp-59809	190	1	as	as	SCONJ
bjp-59809	190	2	mentioned	mention	VERB
bjp-59809	190	3	above	above	ADV
bjp-59809	190	4	,	,	PUNCT
bjp-59809	190	5	caspase-3	caspase-3	NUM
bjp-59809	190	6	acts	act	NOUN
bjp-59809	190	7	as	as	ADP
bjp-59809	190	8	an	an	DET
bjp-59809	190	9	effector	effector	NOUN
bjp-59809	190	10	caspase	caspase	NOUN
bjp-59809	190	11	and	and	CCONJ
bjp-59809	190	12	plays	play	VERB
bjp-59809	190	13	a	a	DET
bjp-59809	190	14	central	central	ADJ
bjp-59809	190	15	role	role	NOUN
bjp-59809	190	16	in	in	ADP
bjp-59809	190	17	both	both	CCONJ
bjp-59809	190	18	extrinsic	extrinsic	ADJ
bjp-59809	190	19	and	and	CCONJ
bjp-59809	190	20	intrinsic	intrinsic	ADJ
bjp-59809	190	21	pathways	pathway	NOUN
bjp-59809	190	22	of	of	ADP
bjp-59809	190	23	apoptosis	apoptosis	NOUN
bjp-59809	190	24	.	.	PUNCT
bjp-59809	191	1	therefore	therefore	ADV
bjp-59809	191	2	,	,	PUNCT
bjp-59809	191	3	active	active	ADJ
bjp-59809	191	4	caspase-3	caspase-3	NUM
bjp-59809	191	5	activity	activity	NOUN
bjp-59809	191	6	in	in	ADP
bjp-59809	191	7	cells	cell	NOUN
bjp-59809	191	8	is	be	AUX
bjp-59809	191	9	directly	directly	ADV
bjp-59809	191	10	related	relate	VERB
bjp-59809	191	11	to	to	ADP
bjp-59809	191	12	apoptosis	apoptosis	VERB
bjp-59809	191	13	.	.	PUNCT
bjp-59809	192	1	in	in	ADP
bjp-59809	192	2	this	this	DET
bjp-59809	192	3	study	study	NOUN
bjp-59809	192	4	,	,	PUNCT
bjp-59809	192	5	active	active	ADJ
bjp-59809	192	6	caspase-3	caspase-3	NUM
bjp-59809	192	7	activity	activity	NOUN
bjp-59809	192	8	was	be	AUX
bjp-59809	192	9	also	also	ADV
bjp-59809	192	10	evaluated	evaluate	VERB
bjp-59809	192	11	,	,	PUNCT
bjp-59809	192	12	and	and	CCONJ
bjp-59809	192	13	a	a	DET
bjp-59809	192	14	significant	significant	ADJ
bjp-59809	192	15	increase	increase	NOUN
bjp-59809	192	16	in	in	ADP
bjp-59809	192	17	caspase-3	caspase-3	NUM
bjp-59809	192	18	activity	activity	NOUN
bjp-59809	192	19	was	be	AUX
bjp-59809	192	20	detected	detect	VERB
bjp-59809	192	21	after	after	ADP
bjp-59809	192	22	treatment	treatment	NOUN
bjp-59809	192	23	with	with	ADP
bjp-59809	192	24	75	75	NUM
bjp-59809	192	25	µm	µm	NOUN
bjp-59809	192	26	and	and	CCONJ
bjp-59809	192	27	100	100	NUM
bjp-59809	192	28	µm	µm	NOUN
bjp-59809	192	29	ak-7	ak-7	ADP
bjp-59809	192	30	when	when	SCONJ
bjp-59809	192	31	compared	compare	VERB
bjp-59809	192	32	with	with	ADP
bjp-59809	192	33	the	the	DET
bjp-59809	192	34	control	control	NOUN
bjp-59809	192	35	group	group	NOUN
bjp-59809	192	36	.	.	PUNCT
bjp-59809	193	1	in	in	ADP
bjp-59809	193	2	addition	addition	NOUN
bjp-59809	193	3	,	,	PUNCT
bjp-59809	193	4	it	it	PRON
bjp-59809	193	5	was	be	AUX
bjp-59809	193	6	determined	determine	VERB
bjp-59809	193	7	that	that	SCONJ
bjp-59809	193	8	caspase-3	caspase-3	NUM
bjp-59809	193	9	activity	activity	NOUN
bjp-59809	193	10	increased	increase	VERB
bjp-59809	193	11	depending	depend	VERB
bjp-59809	193	12	on	on	ADP
bjp-59809	193	13	the	the	DET
bjp-59809	193	14	dose	dose	NOUN
bjp-59809	193	15	of	of	ADP
bjp-59809	193	16	ak-7	ak-7	PROPN
bjp-59809	193	17	.	.	PUNCT
bjp-59809	194	1	conclusion	conclusion	NOUN
bjp-59809	194	2	ak-7	ak-7	ADP
bjp-59809	194	3	,	,	PUNCT
bjp-59809	194	4	a	a	DET
bjp-59809	194	5	selective	selective	ADJ
bjp-59809	194	6	sirt2	sirt2	NOUN
bjp-59809	194	7	inhibitor	inhibitor	NOUN
bjp-59809	194	8	,	,	PUNCT
bjp-59809	194	9	suppresses	suppress	VERB
bjp-59809	194	10	cell	cell	NOUN
bjp-59809	194	11	proliferation	proliferation	NOUN
bjp-59809	194	12	and	and	CCONJ
bjp-59809	194	13	induces	induce	VERB
bjp-59809	194	14	apoptosis	apoptosis	NOUN
bjp-59809	194	15	in	in	ADP
bjp-59809	194	16	a	a	DET
bjp-59809	194	17	dose	dose	NOUN
bjp-59809	194	18	-	-	PUNCT
bjp-59809	194	19	dependent	dependent	ADJ
bjp-59809	194	20	manner	manner	NOUN
bjp-59809	194	21	in	in	ADP
bjp-59809	194	22	glioblastoma	glioblastoma	NOUN
bjp-59809	194	23	multiforme	multiforme	NOUN
bjp-59809	194	24	cells	cell	NOUN
bjp-59809	194	25	.	.	PUNCT
bjp-59809	195	1	these	these	DET
bjp-59809	195	2	findings	finding	NOUN
bjp-59809	195	3	suggest	suggest	VERB
bjp-59809	195	4	that	that	SCONJ
bjp-59809	195	5	sirt2	sirt2	PROPN
bjp-59809	195	6	may	may	AUX
bjp-59809	195	7	be	be	AUX
bjp-59809	195	8	a	a	DET
bjp-59809	195	9	therapeutic	therapeutic	ADJ
bjp-59809	195	10	target	target	NOUN
bjp-59809	195	11	in	in	ADP
bjp-59809	195	12	glioblastoma	glioblastoma	NOUN
bjp-59809	195	13	multiforme	multiforme	NOUN
bjp-59809	195	14	.	.	PUNCT
bjp-59809	196	1	financial	financial	ADJ
bjp-59809	196	2	support	support	NOUN
bjp-59809	196	3	self	self	NOUN
bjp-59809	196	4	-	-	PUNCT
bjp-59809	196	5	funded	fund	VERB
bjp-59809	196	6	conflict	conflict	NOUN
bjp-59809	196	7	of	of	ADP
bjp-59809	196	8	interest	interest	NOUN
bjp-59809	196	9	authors	author	NOUN
bjp-59809	196	10	declare	declare	VERB
bjp-59809	196	11	no	no	DET
bjp-59809	196	12	conflict	conflict	NOUN
bjp-59809	196	13	of	of	ADP
bjp-59809	196	14	interest	interest	NOUN
bjp-59809	196	15	references	reference	NOUN
bjp-59809	196	16	ashkenazi	ashkenazi	AUX
bjp-59809	196	17	a.	a.	NOUN
bjp-59809	196	18	targeting	target	VERB
bjp-59809	196	19	the	the	DET
bjp-59809	196	20	extrinsic	extrinsic	ADJ
bjp-59809	196	21	apoptosis	apoptosis	NOUN
bjp-59809	196	22	pathway	pathway	NOUN
bjp-59809	196	23	in	in	ADP
bjp-59809	196	24	cancer	cancer	NOUN
bjp-59809	196	25	.	.	PUNCT
bjp-59809	197	1	cytokine	cytokine	ADJ
bjp-59809	197	2	growth	growth	NOUN
bjp-59809	197	3	factor	factor	NOUN
bjp-59809	197	4	rev	rev	VERB
bjp-59809	197	5	.	.	PROPN
bjp-59809	197	6	2008	2008	NUM
bjp-59809	197	7	;	;	PUNCT
bjp-59809	197	8	19	19	NUM
bjp-59809	197	9	:	:	SYM
bjp-59809	197	10	325	325	NUM
bjp-59809	197	11	-	-	SYM
bjp-59809	197	12	31	31	NUM
bjp-59809	197	13	.	.	PUNCT
bjp-59809	198	1	aventaggiato	aventaggiato	PROPN
bjp-59809	198	2	m	m	PROPN
bjp-59809	198	3	,	,	PUNCT
bjp-59809	198	4	vernucci	vernucci	NOUN
bjp-59809	198	5	e	e	NOUN
bjp-59809	198	6	,	,	PUNCT
bjp-59809	198	7	barreca	barreca	VERB
bjp-59809	198	8	f	f	PROPN
bjp-59809	198	9	,	,	PUNCT
bjp-59809	198	10	russo	russo	PROPN
bjp-59809	198	11	ma	ma	PROPN
bjp-59809	198	12	,	,	PUNCT
bjp-59809	198	13	tafani	tafani	ADJ
bjp-59809	198	14	m.	m.	NOUN
bjp-59809	198	15	sirtuins	sirtuin	NOUN
bjp-59809	198	16	'	'	PART
bjp-59809	198	17	control	control	NOUN
bjp-59809	198	18	of	of	ADP
bjp-59809	198	19	autophagy	autophagy	NOUN
bjp-59809	198	20	and	and	CCONJ
bjp-59809	198	21	mitophagy	mitophagy	NOUN
bjp-59809	198	22	in	in	ADP
bjp-59809	198	23	cancer	cancer	NOUN
bjp-59809	198	24	.	.	PUNCT
bjp-59809	199	1	48	48	NUM
bjp-59809	199	2	bangladesh	bangladesh	PROPN
bjp-59809	199	3	j	j	PROPN
bjp-59809	199	4	pharmacol	pharmacol	PROPN
bjp-59809	199	5	2022	2022	NUM
bjp-59809	199	6	;	;	PUNCT
bjp-59809	199	7	17	17	NUM
bjp-59809	199	8	:	:	SYM
bjp-59809	199	9	42	42	NUM
bjp-59809	199	10	-	-	SYM
bjp-59809	199	11	50	50	NUM
bjp-59809	199	12	pharmacol	pharmacol	NOUN
bjp-59809	199	13	ther	ther	ADV
bjp-59809	199	14	.	.	PUNCT
bjp-59809	200	1	2021	2021	NUM
bjp-59809	200	2	;	;	PUNCT
bjp-59809	200	3	221	221	NUM
bjp-59809	200	4	:	:	SYM
bjp-59809	200	5	107748	107748	NUM
bjp-59809	200	6	.	.	PUNCT
bjp-59809	201	1	biella	biella	PROPN
bjp-59809	201	2	g	g	PROPN
bjp-59809	201	3	,	,	PUNCT
bjp-59809	201	4	fusco	fusco	PROPN
bjp-59809	201	5	f	f	PROPN
bjp-59809	201	6	,	,	PUNCT
bjp-59809	201	7	nardo	nardo	PROPN
bjp-59809	201	8	e	e	PROPN
bjp-59809	201	9	,	,	PUNCT
bjp-59809	201	10	bernocchi	bernocchi	ADJ
bjp-59809	201	11	o	o	NOUN
bjp-59809	201	12	,	,	PUNCT
bjp-59809	201	13	colombo	colombo	NOUN
bjp-59809	201	14	a	a	PRON
bjp-59809	201	15	,	,	PUNCT
bjp-59809	201	16	lichtenthaler	lichtenthaler	PROPN
bjp-59809	201	17	sf	sf	PROPN
bjp-59809	201	18	,	,	PUNCT
bjp-59809	201	19	forloni	forloni	VERB
bjp-59809	201	20	g	g	PROPN
bjp-59809	201	21	,	,	PUNCT
bjp-59809	201	22	albani	albani	PROPN
bjp-59809	201	23	d.	d.	PROPN
bjp-59809	201	24	sirtuin	sirtuin	PROPN
bjp-59809	201	25	2	2	NUM
bjp-59809	201	26	inhibition	inhibition	NOUN
bjp-59809	201	27	improves	improve	VERB
bjp-59809	201	28	cognitive	cognitive	ADJ
bjp-59809	201	29	performance	performance	NOUN
bjp-59809	201	30	and	and	CCONJ
bjp-59809	201	31	acts	act	VERB
bjp-59809	201	32	on	on	ADP
bjp-59809	201	33	amyloid	amyloid	NOUN
bjp-59809	201	34	-	-	PUNCT
bjp-59809	201	35	β	β	X
bjp-59809	201	36	protein	protein	NOUN
bjp-59809	201	37	precursor	precursor	NOUN
bjp-59809	201	38	processing	processing	NOUN
bjp-59809	201	39	in	in	ADP
bjp-59809	201	40	two	two	NUM
bjp-59809	201	41	alzheimer	alzheimer	NOUN
bjp-59809	201	42	's	's	PART
bjp-59809	201	43	disease	disease	NOUN
bjp-59809	201	44	mouse	mouse	NOUN
bjp-59809	201	45	models	model	NOUN
bjp-59809	201	46	.	.	PUNCT
bjp-59809	202	1	j	j	PROPN
bjp-59809	202	2	alzheimer	alzheimer	PROPN
bjp-59809	202	3	’s	’s	PART
bjp-59809	202	4	dis	dis	PROPN
bjp-59809	202	5	.	.	PROPN
bjp-59809	202	6	2016	2016	NUM
bjp-59809	202	7	;	;	PUNCT
bjp-59809	202	8	53	53	NUM
bjp-59809	202	9	:	:	SYM
bjp-59809	202	10	1193	1193	NUM
bjp-59809	202	11	-	-	SYM
bjp-59809	202	12	207	207	NUM
bjp-59809	202	13	.	.	PUNCT
bjp-59809	203	1	chen	chen	PROPN
bjp-59809	203	2	g	g	PROPN
bjp-59809	203	3	,	,	PUNCT
bjp-59809	203	4	huang	huang	PROPN
bjp-59809	203	5	p	p	PROPN
bjp-59809	203	6	,	,	PUNCT
bjp-59809	203	7	hu	hu	PROPN
bjp-59809	203	8	c.	c.	PROPN
bjp-59809	203	9	the	the	DET
bjp-59809	203	10	role	role	NOUN
bjp-59809	203	11	of	of	ADP
bjp-59809	203	12	sirt2	sirt2	PROPN
bjp-59809	203	13	in	in	ADP
bjp-59809	203	14	cancer	cancer	NOUN
bjp-59809	203	15	:	:	PUNCT
bjp-59809	203	16	a	a	DET
bjp-59809	203	17	novel	novel	ADJ
bjp-59809	203	18	therapeutic	therapeutic	ADJ
bjp-59809	203	19	target	target	NOUN
bjp-59809	203	20	.	.	PUNCT
bjp-59809	204	1	int	int	NOUN
bjp-59809	204	2	j	j	PROPN
bjp-59809	204	3	cancer	cancer	NOUN
bjp-59809	204	4	.	.	PUNCT
bjp-59809	205	1	2020	2020	NUM
bjp-59809	205	2	;	;	PUNCT
bjp-59809	205	3	147	147	NUM
bjp-59809	205	4	:	:	PUNCT
bjp-59809	205	5	3297	3297	NUM
bjp-59809	205	6	-	-	SYM
bjp-59809	205	7	304	304	NUM
bjp-59809	205	8	.	.	PUNCT
bjp-59809	206	1	chen	chen	PROPN
bjp-59809	206	2	j	j	PROPN
bjp-59809	206	3	,	,	PUNCT
bjp-59809	206	4	chan	chan	PROPN
bjp-59809	206	5	aw	aw	INTJ
bjp-59809	206	6	,	,	PUNCT
bjp-59809	206	7	to	to	ADP
bjp-59809	206	8	kf	kf	PROPN
bjp-59809	206	9	,	,	PUNCT
bjp-59809	206	10	chen	chen	PROPN
bjp-59809	206	11	w	w	PROPN
bjp-59809	206	12	,	,	PUNCT
bjp-59809	206	13	zhang	zhang	PROPN
bjp-59809	206	14	z	z	PROPN
bjp-59809	206	15	,	,	PUNCT
bjp-59809	206	16	ren	ren	PROPN
bjp-59809	206	17	j	j	PROPN
bjp-59809	206	18	,	,	PUNCT
bjp-59809	206	19	song	song	NOUN
bjp-59809	206	20	c	c	PROPN
bjp-59809	206	21	,	,	PUNCT
bjp-59809	206	22	cheung	cheung	PROPN
bjp-59809	206	23	ys	ys	PROPN
bjp-59809	206	24	,	,	PUNCT
bjp-59809	206	25	lai	lai	PROPN
bjp-59809	206	26	pb	pb	PROPN
bjp-59809	206	27	,	,	PUNCT
bjp-59809	206	28	cheng	cheng	PROPN
bjp-59809	206	29	sh	sh	PROPN
bjp-59809	206	30	,	,	PUNCT
bjp-59809	206	31	ng	ng	PROPN
bjp-59809	206	32	mh	mh	PROPN
bjp-59809	206	33	,	,	PUNCT
bjp-59809	206	34	huang	huang	PROPN
bjp-59809	206	35	a	a	PROPN
bjp-59809	206	36	,	,	PUNCT
bjp-59809	206	37	ko	ko	PROPN
bjp-59809	206	38	bc	bc	PROPN
bjp-59809	206	39	.	.	PROPN
bjp-59809	207	1	sirt2	sirt2	PROPN
bjp-59809	207	2	overexpression	overexpression	NOUN
bjp-59809	207	3	in	in	ADP
bjp-59809	207	4	hepatocellular	hepatocellular	ADJ
bjp-59809	207	5	carcinoma	carcinoma	NOUN
bjp-59809	207	6	mediates	mediate	NOUN
bjp-59809	207	7	epithelial	epithelial	ADJ
bjp-59809	207	8	to	to	ADP
bjp-59809	207	9	mesenchymal	mesenchymal	ADJ
bjp-59809	207	10	transition	transition	NOUN
bjp-59809	207	11	by	by	ADP
bjp-59809	207	12	protein	protein	NOUN
bjp-59809	207	13	kinase	kinase	PROPN
bjp-59809	207	14	b/	b/	PROPN
bjp-59809	207	15	glycogen	glycogen	NOUN
bjp-59809	207	16	synthase	synthase	NOUN
bjp-59809	207	17	kinase-3β	kinase-3β	PROPN
bjp-59809	207	18	/	/	SYM
bjp-59809	207	19	β	β	NOUN
bjp-59809	207	20	-	-	ADJ
bjp-59809	207	21	catenin	catenin	ADJ
bjp-59809	207	22	signaling	signaling	NOUN
bjp-59809	207	23	.	.	PUNCT
bjp-59809	208	1	hepatology	hepatology	NOUN
bjp-59809	208	2	.	.	PUNCT
bjp-59809	209	1	2013	2013	NUM
bjp-59809	209	2	;	;	PUNCT
bjp-59809	209	3	57	57	NUM
bjp-59809	209	4	:	:	SYM
bjp-59809	209	5	2287	2287	NUM
bjp-59809	209	6	-	-	SYM
bjp-59809	209	7	98	98	NUM
bjp-59809	209	8	.	.	PUNCT
bjp-59809	210	1	chen	chen	PROPN
bjp-59809	210	2	x	x	PROPN
bjp-59809	210	3	,	,	PUNCT
bjp-59809	210	4	wales	wales	PROPN
bjp-59809	210	5	p	p	PROPN
bjp-59809	210	6	,	,	PUNCT
bjp-59809	210	7	quinti	quinti	PROPN
bjp-59809	210	8	l	l	NOUN
bjp-59809	210	9	,	,	PUNCT
bjp-59809	210	10	zuo	zuo	PROPN
bjp-59809	210	11	f	f	PROPN
bjp-59809	210	12	,	,	PUNCT
bjp-59809	210	13	moniot	moniot	PROPN
bjp-59809	210	14	s	s	PROPN
bjp-59809	210	15	,	,	PUNCT
bjp-59809	210	16	herisson	herisson	NOUN
bjp-59809	210	17	f	f	NOUN
bjp-59809	210	18	,	,	PUNCT
bjp-59809	210	19	rauf	rauf	PROPN
bjp-59809	210	20	na	na	PROPN
bjp-59809	210	21	,	,	PUNCT
bjp-59809	210	22	wang	wang	PROPN
bjp-59809	210	23	h	h	PROPN
bjp-59809	210	24	,	,	PUNCT
bjp-59809	210	25	silverman	silverman	NOUN
bjp-59809	210	26	rb	rb	PROPN
bjp-59809	210	27	,	,	PUNCT
bjp-59809	210	28	ayata	ayata	NOUN
bjp-59809	210	29	c	c	NOUN
bjp-59809	210	30	,	,	PUNCT
bjp-59809	210	31	maxwell	maxwell	PROPN
bjp-59809	210	32	mm	mm	PROPN
bjp-59809	210	33	,	,	PUNCT
bjp-59809	210	34	steegborn	steegborn	PROPN
bjp-59809	210	35	c	c	PROPN
bjp-59809	210	36	,	,	PUNCT
bjp-59809	210	37	schwarzschild	schwarzschild	PROPN
bjp-59809	210	38	ma	ma	PROPN
bjp-59809	210	39	,	,	PUNCT
bjp-59809	210	40	outeiro	outeiro	NOUN
bjp-59809	210	41	tf	tf	X
bjp-59809	210	42	,	,	PUNCT
bjp-59809	210	43	kazantsev	kazantsev	PROPN
bjp-59809	210	44	ag	ag	PROPN
bjp-59809	210	45	.	.	PUNCT
bjp-59809	211	1	the	the	DET
bjp-59809	211	2	sirtuin-2	sirtuin-2	NUM
bjp-59809	211	3	inhibitor	inhibitor	NOUN
bjp-59809	211	4	ak7	ak7	NOUN
bjp-59809	211	5	is	be	AUX
bjp-59809	211	6	neuroprotective	neuroprotective	ADJ
bjp-59809	211	7	in	in	ADP
bjp-59809	211	8	models	model	NOUN
bjp-59809	211	9	of	of	ADP
bjp-59809	211	10	parkinson	parkinson	NOUN
bjp-59809	211	11	's	's	PART
bjp-59809	211	12	disease	disease	NOUN
bjp-59809	211	13	but	but	CCONJ
bjp-59809	211	14	not	not	PART
bjp-59809	211	15	amyotrophic	amyotrophic	ADJ
bjp-59809	211	16	lateral	lateral	ADJ
bjp-59809	211	17	sclerosis	sclerosis	NOUN
bjp-59809	211	18	and	and	CCONJ
bjp-59809	211	19	cerebral	cerebral	ADJ
bjp-59809	211	20	ischemia	ischemia	NOUN
bjp-59809	211	21	.	.	PUNCT
bjp-59809	212	1	plos	plos	PROPN
bjp-59809	212	2	one	one	NUM
bjp-59809	212	3	.	.	PUNCT
bjp-59809	212	4	2015	2015	NUM
bjp-59809	212	5	;	;	PUNCT
bjp-59809	212	6	10	10	NUM
bjp-59809	212	7	:	:	PUNCT
bjp-59809	212	8	e0116919	e0116919	PROPN
bjp-59809	212	9	.	.	PUNCT
bjp-59809	213	1	cheon	cheon	PROPN
bjp-59809	213	2	mg	mg	PROPN
bjp-59809	213	3	,	,	PUNCT
bjp-59809	213	4	kim	kim	PROPN
bjp-59809	213	5	w	w	PROPN
bjp-59809	213	6	,	,	PUNCT
bjp-59809	213	7	choi	choi	PROPN
bjp-59809	213	8	m	m	PROPN
bjp-59809	213	9	,	,	PUNCT
bjp-59809	213	10	kim	kim	PROPN
bjp-59809	213	11	je	je	PROPN
bjp-59809	213	12	.	.	PROPN
bjp-59809	213	13	ak-1	ak-1	PUNCT
bjp-59809	213	14	,	,	PUNCT
bjp-59809	213	15	a	a	DET
bjp-59809	213	16	specific	specific	ADJ
bjp-59809	213	17	sirt2	sirt2	NOUN
bjp-59809	213	18	inhibitor	inhibitor	NOUN
bjp-59809	213	19	,	,	PUNCT
bjp-59809	213	20	induces	induce	VERB
bjp-59809	213	21	cell	cell	NOUN
bjp-59809	213	22	cycle	cycle	NOUN
bjp-59809	213	23	arrest	arrest	NOUN
bjp-59809	213	24	by	by	ADP
bjp-59809	213	25	downregulating	downregulate	VERB
bjp-59809	213	26	snail	snail	NOUN
bjp-59809	213	27	in	in	ADP
bjp-59809	213	28	hct116	hct116	PROPN
bjp-59809	213	29	human	human	ADJ
bjp-59809	213	30	colon	colon	NOUN
bjp-59809	213	31	carcinoma	carcinoma	NOUN
bjp-59809	213	32	cells	cell	NOUN
bjp-59809	213	33	.	.	PUNCT
bjp-59809	214	1	cancer	cancer	PROPN
bjp-59809	214	2	lett	lett	PROPN
bjp-59809	214	3	.	.	PROPN
bjp-59809	215	1	2015	2015	NUM
bjp-59809	215	2	;	;	PUNCT
bjp-59809	215	3	356	356	NUM
bjp-59809	215	4	:	:	PUNCT
bjp-59809	215	5	637	637	NUM
bjp-59809	215	6	-	-	SYM
bjp-59809	215	7	45	45	NUM
bjp-59809	215	8	.	.	PUNCT
bjp-59809	216	1	chopra	chopra	PROPN
bjp-59809	216	2	v	v	PROPN
bjp-59809	216	3	,	,	PUNCT
bjp-59809	216	4	quinti	quinti	PROPN
bjp-59809	216	5	l	l	PROPN
bjp-59809	216	6	,	,	PUNCT
bjp-59809	216	7	kim	kim	PROPN
bjp-59809	216	8	j	j	PROPN
bjp-59809	216	9	,	,	PUNCT
bjp-59809	216	10	vollor	vollor	PROPN
bjp-59809	216	11	l	l	PROPN
bjp-59809	216	12	,	,	PUNCT
bjp-59809	216	13	narayanan	narayanan	PROPN
bjp-59809	216	14	kl	kl	PROPN
bjp-59809	216	15	,	,	PUNCT
bjp-59809	216	16	edgerly	edgerly	ADV
bjp-59809	216	17	c	c	X
bjp-59809	216	18	,	,	PUNCT
bjp-59809	216	19	cipicchio	cipicchio	VERB
bjp-59809	216	20	pm	pm	NOUN
bjp-59809	216	21	,	,	PUNCT
bjp-59809	216	22	lauver	lauver	PROPN
bjp-59809	216	23	ma	ma	PROPN
bjp-59809	216	24	,	,	PUNCT
bjp-59809	216	25	choi	choi	PROPN
bjp-59809	216	26	sh	sh	PROPN
bjp-59809	216	27	,	,	PUNCT
bjp-59809	216	28	silverman	silverman	NOUN
bjp-59809	216	29	rb	rb	PROPN
bjp-59809	216	30	,	,	PUNCT
bjp-59809	216	31	ferrante	ferrante	PROPN
bjp-59809	216	32	rj	rj	PROPN
bjp-59809	216	33	,	,	PUNCT
bjp-59809	216	34	hersch	hersch	PROPN
bjp-59809	216	35	s	s	PROPN
bjp-59809	216	36	,	,	PUNCT
bjp-59809	216	37	kazantsev	kazantsev	PROPN
bjp-59809	216	38	ag	ag	PROPN
bjp-59809	216	39	.	.	PUNCT
bjp-59809	217	1	the	the	DET
bjp-59809	217	2	sirtuin	sirtuin	ADJ
bjp-59809	217	3	2	2	NUM
bjp-59809	217	4	inhibitor	inhibitor	NOUN
bjp-59809	217	5	ak7	ak7	NOUN
bjp-59809	217	6	is	be	AUX
bjp-59809	217	7	neuroprotective	neuroprotective	ADJ
bjp-59809	217	8	in	in	ADP
bjp-59809	217	9	huntington	huntington	PROPN
bjp-59809	217	10	's	's	PART
bjp-59809	217	11	disease	disease	NOUN
bjp-59809	217	12	mouse	mouse	NOUN
bjp-59809	217	13	models	model	NOUN
bjp-59809	217	14	.	.	PUNCT
bjp-59809	218	1	cell	cell	NOUN
bjp-59809	218	2	rep	rep	PROPN
bjp-59809	218	3	.	.	PROPN
bjp-59809	218	4	2012	2012	NUM
bjp-59809	218	5	;	;	PUNCT
bjp-59809	218	6	2	2	NUM
bjp-59809	218	7	:	:	SYM
bjp-59809	218	8	1492	1492	NUM
bjp-59809	218	9	-	-	SYM
bjp-59809	218	10	97	97	NUM
bjp-59809	218	11	.	.	PUNCT
bjp-59809	219	1	çınar	çınar	PROPN
bjp-59809	219	2	ayan	ayan	PROPN
bjp-59809	219	3	i̇	i̇	PROPN
bjp-59809	219	4	,	,	PUNCT
bjp-59809	219	5	çetinkaya	çetinkaya	PROPN
bjp-59809	219	6	s	s	PROPN
bjp-59809	219	7	,	,	PUNCT
bjp-59809	219	8	dursun	dursun	NOUN
bjp-59809	219	9	hg	hg	NOUN
bjp-59809	219	10	,	,	PUNCT
bjp-59809	219	11	süntar	süntar	VERB
bjp-59809	219	12	i̇.	i̇.	PROPN
bjp-59809	219	13	bioactive	bioactive	VERB
bjp-59809	219	14	compounds	compound	NOUN
bjp-59809	219	15	of	of	ADP
bjp-59809	219	16	rheum	rheum	NOUN
bjp-59809	219	17	ribes	ribe	NOUN
bjp-59809	219	18	l.	l.	NOUN
bjp-59809	219	19	and	and	CCONJ
bjp-59809	219	20	its	its	PRON
bjp-59809	219	21	anticancerogenic	anticancerogenic	ADJ
bjp-59809	219	22	effect	effect	NOUN
bjp-59809	219	23	via	via	ADP
bjp-59809	219	24	induction	induction	NOUN
bjp-59809	219	25	of	of	ADP
bjp-59809	219	26	apoptosis	apoptosis	NOUN
bjp-59809	219	27	and	and	CCONJ
bjp-59809	219	28	mir-200	mir-200	NOUN
bjp-59809	219	29	family	family	NOUN
bjp-59809	219	30	expression	expression	NOUN
bjp-59809	219	31	in	in	ADP
bjp-59809	219	32	human	human	ADJ
bjp-59809	219	33	colorectal	colorectal	ADJ
bjp-59809	219	34	cancer	cancer	NOUN
bjp-59809	219	35	cells	cell	NOUN
bjp-59809	219	36	.	.	PUNCT
bjp-59809	220	1	nutr	nutr	NOUN
bjp-59809	220	2	cancer	cancer	NOUN
bjp-59809	220	3	.	.	PUNCT
bjp-59809	221	1	2021a	2021a	NUM
bjp-59809	221	2	;	;	PUNCT
bjp-59809	222	1	73	73	NUM
bjp-59809	222	2	:	:	SYM
bjp-59809	222	3	1228	1228	NUM
bjp-59809	222	4	-	-	SYM
bjp-59809	222	5	43	43	NUM
bjp-59809	222	6	.	.	PUNCT
bjp-59809	223	1	çınar	çınar	PROPN
bjp-59809	223	2	ai̇	ai̇	NOUN
bjp-59809	223	3	,	,	PUNCT
bjp-59809	223	4	güçlü	güçlü	NOUN
bjp-59809	223	5	e	e	NOUN
bjp-59809	223	6	,	,	PUNCT
bjp-59809	223	7	dursun	dursun	NOUN
bjp-59809	223	8	h.g	h.g	PROPN
bjp-59809	223	9	,	,	PUNCT
bjp-59809	223	10	vural	vural	PROPN
bjp-59809	223	11	h.	h.	PROPN
bjp-59809	223	12	tomentosin	tomentosin	PROPN
bjp-59809	223	13	shows	show	VERB
bjp-59809	223	14	anticancer	anticancer	NOUN
bjp-59809	223	15	effect	effect	NOUN
bjp-59809	223	16	on	on	ADP
bjp-59809	223	17	u87	u87	ADJ
bjp-59809	223	18	human	human	ADJ
bjp-59809	223	19	glioblastoma	glioblastoma	NOUN
bjp-59809	223	20	multiforme	multiforme	NOUN
bjp-59809	223	21	cells	cell	NOUN
bjp-59809	223	22	.	.	PUNCT
bjp-59809	224	1	bull	bull	NOUN
bjp-59809	224	2	biotechnol	biotechnol	NOUN
bjp-59809	224	3	.	.	PUNCT
bjp-59809	225	1	2021b	2021b	NUM
bjp-59809	225	2	;	;	PUNCT
bjp-59809	226	1	2	2	NUM
bjp-59809	226	2	:	:	SYM
bjp-59809	226	3	23	23	NUM
bjp-59809	226	4	-	-	SYM
bjp-59809	226	5	26	26	NUM
bjp-59809	226	6	.	.	PUNCT
bjp-59809	226	7	du	du	PROPN
bjp-59809	226	8	y	y	PROPN
bjp-59809	226	9	,	,	PUNCT
bjp-59809	226	10	wu	wu	PROPN
bjp-59809	226	11	j	j	PROPN
bjp-59809	226	12	,	,	PUNCT
bjp-59809	226	13	zhang	zhang	PROPN
bjp-59809	226	14	h	h	PROPN
bjp-59809	226	15	,	,	PUNCT
bjp-59809	226	16	li	li	PROPN
bjp-59809	226	17	s	s	PROPN
bjp-59809	226	18	,	,	PUNCT
bjp-59809	226	19	sun	sun	PROPN
bjp-59809	226	20	h.	h.	PROPN
bjp-59809	226	21	reduced	reduce	VERB
bjp-59809	226	22	expression	expression	NOUN
bjp-59809	226	23	of	of	ADP
bjp-59809	226	24	sirt2	sirt2	PROPN
bjp-59809	226	25	in	in	ADP
bjp-59809	226	26	serous	serous	ADJ
bjp-59809	226	27	ovarian	ovarian	ADJ
bjp-59809	226	28	carcinoma	carcinoma	NOUN
bjp-59809	226	29	promotes	promote	VERB
bjp-59809	226	30	cell	cell	NOUN
bjp-59809	226	31	proliferation	proliferation	NOUN
bjp-59809	226	32	through	through	ADP
bjp-59809	226	33	disinhibition	disinhibition	NOUN
bjp-59809	226	34	of	of	ADP
bjp-59809	226	35	cdk4	cdk4	NOUN
bjp-59809	226	36	expression	expression	NOUN
bjp-59809	226	37	.	.	PUNCT
bjp-59809	227	1	mol	mol	ADP
bjp-59809	227	2	med	med	PROPN
bjp-59809	227	3	rep	rep	PROPN
bjp-59809	227	4	.	.	PROPN
bjp-59809	227	5	2017	2017	NUM
bjp-59809	227	6	;	;	PUNCT
bjp-59809	227	7	15	15	NUM
bjp-59809	227	8	:	:	SYM
bjp-59809	227	9	1638	1638	NUM
bjp-59809	227	10	-	-	SYM
bjp-59809	227	11	46	46	NUM
bjp-59809	227	12	.	.	PUNCT
bjp-59809	228	1	elmore	elmore	NOUN
bjp-59809	228	2	s.	s.	PROPN
bjp-59809	228	3	apoptosis	apoptosis	PROPN
bjp-59809	228	4	:	:	PUNCT
bjp-59809	228	5	a	a	DET
bjp-59809	228	6	review	review	NOUN
bjp-59809	228	7	of	of	ADP
bjp-59809	228	8	programmed	program	VERB
bjp-59809	228	9	cell	cell	NOUN
bjp-59809	228	10	death	death	NOUN
bjp-59809	228	11	.	.	PUNCT
bjp-59809	229	1	toxicol	toxicol	PROPN
bjp-59809	229	2	pathol	pathol	NOUN
bjp-59809	229	3	.	.	PUNCT
bjp-59809	230	1	2007	2007	NUM
bjp-59809	230	2	;	;	PUNCT
bjp-59809	230	3	35	35	NUM
bjp-59809	230	4	:	:	SYM
bjp-59809	230	5	495	495	NUM
bjp-59809	230	6	-	-	SYM
bjp-59809	230	7	516	516	NUM
bjp-59809	230	8	.	.	PUNCT
bjp-59809	231	1	funato	funato	PROPN
bjp-59809	231	2	k	k	PROPN
bjp-59809	231	3	,	,	PUNCT
bjp-59809	231	4	hayashi	hayashi	PROPN
bjp-59809	231	5	t	t	PROPN
bjp-59809	231	6	,	,	PUNCT
bjp-59809	231	7	echizen	echizen	PROPN
bjp-59809	231	8	k	k	PROPN
bjp-59809	231	9	,	,	PUNCT
bjp-59809	231	10	negishi	negishi	PROPN
bjp-59809	231	11	l	l	PROPN
bjp-59809	231	12	,	,	PUNCT
bjp-59809	231	13	shimizu	shimizu	PROPN
bjp-59809	231	14	n	n	PROPN
bjp-59809	231	15	,	,	PUNCT
bjp-59809	231	16	koyama	koyama	PROPN
bjp-59809	231	17	-	-	PUNCT
bjp-59809	231	18	nasu	nasu	PROPN
bjp-59809	231	19	r	r	PROPN
bjp-59809	231	20	,	,	PUNCT
bjp-59809	231	21	nasu	nasu	NOUN
bjp-59809	231	22	-	-	PUNCT
bjp-59809	231	23	nishimura	nishimura	PROPN
bjp-59809	231	24	y	y	PROPN
bjp-59809	231	25	,	,	PUNCT
bjp-59809	231	26	morishita	morishita	PROPN
bjp-59809	231	27	y	y	PROPN
bjp-59809	231	28	,	,	PUNCT
bjp-59809	231	29	tabar	tabar	PROPN
bjp-59809	231	30	v	v	NOUN
bjp-59809	231	31	,	,	PUNCT
bjp-59809	231	32	todo	todo	NOUN
bjp-59809	231	33	t	t	PROPN
bjp-59809	231	34	,	,	PUNCT
bjp-59809	231	35	ino	ino	VERB
bjp-59809	231	36	y	y	PROPN
bjp-59809	231	37	,	,	PUNCT
bjp-59809	231	38	mukasa	mukasa	PROPN
bjp-59809	231	39	a	a	PROPN
bjp-59809	231	40	,	,	PUNCT
bjp-59809	231	41	saito	saito	PROPN
bjp-59809	231	42	n	n	CCONJ
bjp-59809	231	43	,	,	PUNCT
bjp-59809	231	44	akiyama	akiyama	PROPN
bjp-59809	231	45	t.	t.	PROPN
bjp-59809	231	46	sirt2mediated	sirt2mediate	VERB
bjp-59809	231	47	inactivation	inactivation	NOUN
bjp-59809	231	48	of	of	ADP
bjp-59809	231	49	p73	p73	NOUN
bjp-59809	231	50	is	be	AUX
bjp-59809	231	51	required	require	VERB
bjp-59809	231	52	for	for	ADP
bjp-59809	231	53	glioblastoma	glioblastoma	NOUN
bjp-59809	231	54	tumorigenicity	tumorigenicity	NOUN
bjp-59809	231	55	.	.	PUNCT
bjp-59809	232	1	embo	embo	PROPN
bjp-59809	232	2	rep	rep	PROPN
bjp-59809	232	3	.	.	PROPN
bjp-59809	232	4	2018	2018	NUM
bjp-59809	232	5	;	;	PUNCT
bjp-59809	232	6	19	19	NUM
bjp-59809	232	7	:	:	PUNCT
bjp-59809	232	8	e45587	e45587	X
bjp-59809	232	9	.	.	PUNCT
bjp-59809	233	1	george	george	PROPN
bjp-59809	233	2	j	j	PROPN
bjp-59809	233	3	,	,	PUNCT
bjp-59809	233	4	ahmad	ahmad	PROPN
bjp-59809	233	5	n.	n.	PROPN
bjp-59809	233	6	mitochondrial	mitochondrial	ADJ
bjp-59809	233	7	sirtuins	sirtuin	NOUN
bjp-59809	233	8	in	in	ADP
bjp-59809	233	9	cancer	cancer	NOUN
bjp-59809	233	10	:	:	PUNCT
bjp-59809	233	11	emerging	emerge	VERB
bjp-59809	233	12	roles	role	NOUN
bjp-59809	233	13	and	and	CCONJ
bjp-59809	233	14	therapeutic	therapeutic	ADJ
bjp-59809	233	15	potential	potential	NOUN
bjp-59809	233	16	.	.	PUNCT
bjp-59809	234	1	cancer	cancer	NOUN
bjp-59809	234	2	res	re	NOUN
bjp-59809	234	3	.	.	PROPN
bjp-59809	234	4	2016	2016	NUM
bjp-59809	234	5	;	;	PUNCT
bjp-59809	234	6	76	76	NUM
bjp-59809	234	7	:	:	SYM
bjp-59809	234	8	2500	2500	NUM
bjp-59809	234	9	-	-	SYM
bjp-59809	234	10	06	06	NUM
bjp-59809	234	11	.	.	PUNCT
bjp-59809	235	1	ghani	ghani	PROPN
bjp-59809	235	2	ari	ari	PROPN
bjp-59809	235	3	,	,	PUNCT
bjp-59809	235	4	yahya	yahya	PROPN
bjp-59809	235	5	eb	eb	PROPN
bjp-59809	235	6	,	,	PUNCT
bjp-59809	235	7	allaq	allaq	PROPN
bjp-59809	235	8	aa	aa	PROPN
bjp-59809	235	9	,	,	PUNCT
bjp-59809	235	10	khalil	khalil	PROPN
bjp-59809	235	11	asa	asa	PROPN
bjp-59809	235	12	.	.	PROPN
bjp-59809	235	13	novel	novel	ADJ
bjp-59809	235	14	insights	insight	NOUN
bjp-59809	235	15	into	into	ADP
bjp-59809	235	16	genetic	genetic	ADJ
bjp-59809	235	17	approaches	approach	NOUN
bjp-59809	235	18	in	in	ADP
bjp-59809	235	19	glioblastoma	glioblastoma	NOUN
bjp-59809	235	20	multiforme	multiforme	NOUN
bjp-59809	235	21	therapy	therapy	NOUN
bjp-59809	235	22	.	.	PUNCT
bjp-59809	235	23	biomed	biome	VERB
bjp-59809	235	24	res	re	NOUN
bjp-59809	235	25	ther	ther	ADV
bjp-59809	235	26	.	.	PUNCT
bjp-59809	236	1	2022	2022	NUM
bjp-59809	236	2	;	;	PUNCT
bjp-59809	236	3	9	9	NUM
bjp-59809	236	4	:	:	SYM
bjp-59809	236	5	4851	4851	NUM
bjp-59809	236	6	-	-	SYM
bjp-59809	236	7	64	64	NUM
bjp-59809	236	8	.	.	PUNCT
bjp-59809	237	1	güçlü	güçlü	PROPN
bjp-59809	237	2	e	e	NOUN
bjp-59809	237	3	,	,	PUNCT
bjp-59809	237	4	eroğlu	eroğlu	ADJ
bjp-59809	237	5	güneş	güneş	NOUN
bjp-59809	237	6	c	c	NOUN
bjp-59809	237	7	,	,	PUNCT
bjp-59809	237	8	kurar	kurar	NOUN
bjp-59809	237	9	e	e	NOUN
bjp-59809	237	10	,	,	PUNCT
bjp-59809	237	11	vural	vural	PROPN
bjp-59809	237	12	h.	h.	PROPN
bjp-59809	237	13	knockdown	knockdown	NOUN
bjp-59809	237	14	of	of	ADP
bjp-59809	237	15	lncrna	lncrna	NOUN
bjp-59809	237	16	hif1a	hif1a	NOUN
bjp-59809	237	17	-	-	PUNCT
bjp-59809	237	18	as2	as2	PROPN
bjp-59809	237	19	increases	increase	VERB
bjp-59809	237	20	drug	drug	NOUN
bjp-59809	237	21	sensitivity	sensitivity	NOUN
bjp-59809	237	22	of	of	ADP
bjp-59809	237	23	sclc	sclc	PROPN
bjp-59809	237	24	cells	cell	NOUN
bjp-59809	237	25	in	in	ADP
bjp-59809	237	26	association	association	NOUN
bjp-59809	237	27	with	with	ADP
bjp-59809	237	28	autophagy	autophagy	NOUN
bjp-59809	237	29	.	.	PUNCT
bjp-59809	238	1	med	med	PROPN
bjp-59809	238	2	oncol	oncol	ADJ
bjp-59809	238	3	.	.	PUNCT
bjp-59809	239	1	2021	2021	NUM
bjp-59809	239	2	;	;	PUNCT
bjp-59809	239	3	38	38	NUM
bjp-59809	239	4	:	:	SYM
bjp-59809	239	5	113	113	NUM
bjp-59809	239	6	.	.	PUNCT
bjp-59809	239	7	hu	hu	PROPN
bjp-59809	240	1	f	f	PROPN
bjp-59809	240	2	,	,	PUNCT
bjp-59809	240	3	sun	sun	PROPN
bjp-59809	240	4	x	x	PROPN
bjp-59809	240	5	,	,	PUNCT
bjp-59809	240	6	li	li	PROPN
bjp-59809	240	7	g	g	PROPN
bjp-59809	240	8	,	,	PUNCT
bjp-59809	240	9	wu	wu	PROPN
bjp-59809	240	10	q	q	PROPN
bjp-59809	240	11	,	,	PUNCT
bjp-59809	240	12	chen	chen	PROPN
bjp-59809	240	13	y	y	PROPN
bjp-59809	240	14	,	,	PUNCT
bjp-59809	240	15	yang	yang	PROPN
bjp-59809	240	16	x	x	PROPN
bjp-59809	240	17	,	,	PUNCT
bjp-59809	240	18	luo	luo	PROPN
bjp-59809	240	19	x	x	PROPN
bjp-59809	240	20	,	,	PUNCT
bjp-59809	240	21	hu	hu	PROPN
bjp-59809	240	22	j	j	PROPN
bjp-59809	240	23	,	,	PUNCT
bjp-59809	240	24	wang	wang	PROPN
bjp-59809	240	25	g.	g.	PROPN
bjp-59809	240	26	inhibition	inhibition	NOUN
bjp-59809	240	27	of	of	ADP
bjp-59809	240	28	sirt2	sirt2	PROPN
bjp-59809	240	29	limits	limit	VERB
bjp-59809	240	30	tumour	tumour	PRON
bjp-59809	240	31	angiogenesis	angiogenesis	NOUN
bjp-59809	240	32	via	via	ADP
bjp-59809	240	33	inactivation	inactivation	NOUN
bjp-59809	240	34	of	of	ADP
bjp-59809	240	35	the	the	DET
bjp-59809	240	36	stat3	stat3	PROPN
bjp-59809	240	37	/	/	SYM
bjp-59809	240	38	vegfa	vegfa	PROPN
bjp-59809	240	39	signalling	signal	VERB
bjp-59809	240	40	pathway	pathway	NOUN
bjp-59809	240	41	.	.	PUNCT
bjp-59809	241	1	cell	cell	NOUN
bjp-59809	241	2	death	death	NOUN
bjp-59809	241	3	dis	dis	PROPN
bjp-59809	241	4	.	.	PUNCT
bjp-59809	241	5	2018	2018	NUM
bjp-59809	241	6	;	;	PUNCT
bjp-59809	241	7	10	10	NUM
bjp-59809	241	8	:	:	SYM
bjp-59809	241	9	9	9	NUM
bjp-59809	241	10	.	.	X
bjp-59809	242	1	huang	huang	PROPN
bjp-59809	242	2	s	s	PROPN
bjp-59809	242	3	,	,	PUNCT
bjp-59809	242	4	zhao	zhao	PROPN
bjp-59809	242	5	z	z	PROPN
bjp-59809	242	6	,	,	PUNCT
bjp-59809	242	7	tang	tang	PROPN
bjp-59809	242	8	d	d	NOUN
bjp-59809	242	9	,	,	PUNCT
bjp-59809	242	10	zhou	zhou	PROPN
bjp-59809	242	11	q	q	PROPN
bjp-59809	242	12	,	,	PUNCT
bjp-59809	242	13	li	li	PROPN
bjp-59809	242	14	y	y	PROPN
bjp-59809	242	15	,	,	PUNCT
bjp-59809	242	16	zhou	zhou	PROPN
bjp-59809	242	17	l	l	PROPN
bjp-59809	242	18	,	,	PUNCT
bjp-59809	242	19	yin	yin	PROPN
bjp-59809	242	20	y	y	PROPN
bjp-59809	242	21	,	,	PUNCT
bjp-59809	242	22	wang	wang	PROPN
bjp-59809	242	23	y	y	PROPN
bjp-59809	242	24	,	,	PUNCT
bjp-59809	242	25	pan	pan	PROPN
bjp-59809	242	26	y	y	PROPN
bjp-59809	242	27	,	,	PUNCT
bjp-59809	242	28	dorfman	dorfman	PROPN
bjp-59809	242	29	rg	rg	PROPN
bjp-59809	242	30	,	,	PUNCT
bjp-59809	242	31	ling	ling	PROPN
bjp-59809	242	32	t	t	PROPN
bjp-59809	242	33	,	,	PUNCT
bjp-59809	242	34	zhang	zhang	PROPN
bjp-59809	242	35	m.	m.	PROPN
bjp-59809	242	36	down	down	ADP
bjp-59809	242	37	-	-	PUNCT
bjp-59809	242	38	regulation	regulation	NOUN
bjp-59809	242	39	of	of	ADP
bjp-59809	242	40	sirt2	sirt2	PROPN
bjp-59809	242	41	inhibits	inhibit	VERB
bjp-59809	242	42	invasion	invasion	NOUN
bjp-59809	242	43	of	of	ADP
bjp-59809	242	44	hepatocellular	hepatocellular	ADJ
bjp-59809	242	45	carcinoma	carcinoma	NOUN
bjp-59809	242	46	by	by	ADP
bjp-59809	242	47	inhibiting	inhibit	VERB
bjp-59809	242	48	energy	energy	NOUN
bjp-59809	242	49	metabolism	metabolism	NOUN
bjp-59809	242	50	.	.	PUNCT
bjp-59809	243	1	transl	transl	PROPN
bjp-59809	243	2	oncol	oncol	PROPN
bjp-59809	243	3	.	.	PUNCT
bjp-59809	244	1	2017	2017	NUM
bjp-59809	244	2	;	;	PUNCT
bjp-59809	244	3	10	10	NUM
bjp-59809	244	4	:	:	SYM
bjp-59809	244	5	91727	91727	NUM
bjp-59809	244	6	.	.	PUNCT
bjp-59809	245	1	inoue	inoue	PROPN
bjp-59809	245	2	s	s	PROPN
bjp-59809	245	3	,	,	PUNCT
bjp-59809	245	4	browne	browne	PROPN
bjp-59809	245	5	g	g	PROPN
bjp-59809	245	6	,	,	PUNCT
bjp-59809	245	7	melino	melino	PROPN
bjp-59809	245	8	g	g	NOUN
bjp-59809	245	9	,	,	PUNCT
bjp-59809	245	10	cohen	cohen	PROPN
bjp-59809	245	11	gm	gm	PROPN
bjp-59809	245	12	.	.	PUNCT
bjp-59809	246	1	ordering	order	VERB
bjp-59809	246	2	of	of	ADP
bjp-59809	246	3	caspases	caspase	NOUN
bjp-59809	246	4	in	in	ADP
bjp-59809	246	5	cells	cell	NOUN
bjp-59809	246	6	undergoing	undergo	VERB
bjp-59809	246	7	apoptosis	apoptosis	NOUN
bjp-59809	246	8	by	by	ADP
bjp-59809	246	9	the	the	DET
bjp-59809	246	10	intrinsic	intrinsic	ADJ
bjp-59809	246	11	pathway	pathway	NOUN
bjp-59809	246	12	.	.	PUNCT
bjp-59809	247	1	cell	cell	NOUN
bjp-59809	247	2	death	death	NOUN
bjp-59809	247	3	differ	differ	VERB
bjp-59809	247	4	.	.	PUNCT
bjp-59809	248	1	2009	2009	NUM
bjp-59809	248	2	;	;	PUNCT
bjp-59809	248	3	16	16	NUM
bjp-59809	248	4	:	:	SYM
bjp-59809	248	5	1053	1053	NUM
bjp-59809	248	6	-	-	SYM
bjp-59809	248	7	61	61	NUM
bjp-59809	248	8	.	.	PUNCT
bjp-59809	249	1	jing	jing	PROPN
bjp-59809	249	2	h	h	PROPN
bjp-59809	249	3	,	,	PUNCT
bjp-59809	249	4	hu	hu	PROPN
bjp-59809	250	1	j	j	PROPN
bjp-59809	250	2	,	,	PUNCT
bjp-59809	250	3	he	he	PRON
bjp-59809	250	4	b	b	PROPN
bjp-59809	250	5	,	,	PUNCT
bjp-59809	250	6	negrón	negrón	PROPN
bjp-59809	250	7	abril	abril	PROPN
bjp-59809	250	8	yl	yl	PROPN
bjp-59809	250	9	,	,	PUNCT
bjp-59809	250	10	stupinski	stupinski	PROPN
bjp-59809	250	11	j	j	PROPN
bjp-59809	250	12	,	,	PUNCT
bjp-59809	250	13	weiser	weiser	PROPN
bjp-59809	250	14	k	k	PROPN
bjp-59809	250	15	,	,	PUNCT
bjp-59809	250	16	carbonaro	carbonaro	PROPN
bjp-59809	250	17	m	m	PROPN
bjp-59809	250	18	,	,	PUNCT
bjp-59809	250	19	chiang	chiang	PROPN
bjp-59809	250	20	yl	yl	PROPN
bjp-59809	250	21	,	,	PUNCT
bjp-59809	250	22	southard	southard	PROPN
bjp-59809	250	23	t	t	PROPN
bjp-59809	250	24	,	,	PUNCT
bjp-59809	250	25	giannakakou	giannakakou	PROPN
bjp-59809	250	26	p	p	PROPN
bjp-59809	250	27	,	,	PUNCT
bjp-59809	250	28	weiss	weiss	NOUN
bjp-59809	250	29	rs	rs	NOUN
bjp-59809	250	30	,	,	PUNCT
bjp-59809	250	31	lin	lin	PROPN
bjp-59809	250	32	h.	h.	PROPN
bjp-59809	251	1	a	a	DET
bjp-59809	251	2	sirt2	sirt2	PROPN
bjp-59809	251	3	-	-	PUNCT
bjp-59809	251	4	selective	selective	ADJ
bjp-59809	251	5	inhibitor	inhibitor	NOUN
bjp-59809	251	6	promotes	promote	VERB
bjp-59809	251	7	cmyc	cmyc	PROPN
bjp-59809	251	8	oncoprotein	oncoprotein	ADJ
bjp-59809	251	9	degradation	degradation	NOUN
bjp-59809	251	10	and	and	CCONJ
bjp-59809	251	11	exhibits	exhibit	VERB
bjp-59809	251	12	broad	broad	ADJ
bjp-59809	251	13	anticancer	anticancer	NOUN
bjp-59809	251	14	activity	activity	NOUN
bjp-59809	251	15	.	.	PUNCT
bjp-59809	252	1	cancer	cancer	NOUN
bjp-59809	252	2	cell	cell	NOUN
bjp-59809	252	3	.	.	PUNCT
bjp-59809	253	1	2016	2016	NUM
bjp-59809	253	2	;	;	PUNCT
bjp-59809	253	3	29	29	NUM
bjp-59809	253	4	:	:	SYM
bjp-59809	253	5	297	297	NUM
bjp-59809	253	6	-	-	SYM
bjp-59809	253	7	310	310	NUM
bjp-59809	253	8	.	.	PUNCT
bjp-59809	254	1	kim	kim	PROPN
bjp-59809	254	2	hs	hs	PROPN
bjp-59809	254	3	,	,	PUNCT
bjp-59809	254	4	vassilopoulos	vassilopoulos	PROPN
bjp-59809	254	5	a	a	PROPN
bjp-59809	254	6	,	,	PUNCT
bjp-59809	254	7	wang	wang	PROPN
bjp-59809	254	8	rh	rh	PROPN
bjp-59809	254	9	,	,	PUNCT
bjp-59809	254	10	lahusen	lahusen	PROPN
bjp-59809	254	11	t	t	PROPN
bjp-59809	254	12	,	,	PUNCT
bjp-59809	254	13	xiao	xiao	PROPN
bjp-59809	254	14	z	z	PROPN
bjp-59809	254	15	,	,	PUNCT
bjp-59809	254	16	xu	xu	PROPN
bjp-59809	254	17	x	x	PROPN
bjp-59809	254	18	,	,	PUNCT
bjp-59809	254	19	li	li	PROPN
bjp-59809	254	20	c	c	PROPN
bjp-59809	254	21	,	,	PUNCT
bjp-59809	254	22	veenstra	veenstra	ADJ
bjp-59809	254	23	td	td	PROPN
bjp-59809	254	24	,	,	PUNCT
bjp-59809	254	25	li	li	PROPN
bjp-59809	254	26	b	b	PROPN
bjp-59809	254	27	,	,	PUNCT
bjp-59809	254	28	yu	yu	PROPN
bjp-59809	254	29	h	h	PROPN
bjp-59809	254	30	,	,	PUNCT
bjp-59809	254	31	ji	ji	PROPN
bjp-59809	254	32	j	j	PROPN
bjp-59809	254	33	,	,	PUNCT
bjp-59809	254	34	wang	wang	PROPN
bjp-59809	254	35	xw	xw	PROPN
bjp-59809	254	36	,	,	PUNCT
bjp-59809	254	37	park	park	PROPN
bjp-59809	254	38	sh	sh	PROPN
bjp-59809	254	39	,	,	PUNCT
bjp-59809	254	40	cha	cha	PROPN
bjp-59809	254	41	yi	yi	PROPN
bjp-59809	254	42	,	,	PUNCT
bjp-59809	254	43	gius	gius	NOUN
bjp-59809	254	44	d	d	PROPN
bjp-59809	254	45	,	,	PUNCT
bjp-59809	254	46	deng	deng	PROPN
bjp-59809	254	47	cx	cx	PROPN
bjp-59809	254	48	.	.	PUNCT
bjp-59809	254	49	sirt2	sirt2	PROPN
bjp-59809	254	50	maintains	maintain	VERB
bjp-59809	254	51	genome	genome	NOUN
bjp-59809	254	52	integrity	integrity	NOUN
bjp-59809	254	53	and	and	CCONJ
bjp-59809	254	54	suppresses	suppress	VERB
bjp-59809	254	55	tumorigenesis	tumorigenesis	NOUN
bjp-59809	254	56	through	through	ADP
bjp-59809	254	57	regulating	regulate	VERB
bjp-59809	254	58	apc	apc	PROPN
bjp-59809	254	59	/	/	SYM
bjp-59809	254	60	c	c	NOUN
bjp-59809	254	61	activity	activity	NOUN
bjp-59809	254	62	.	.	PUNCT
bjp-59809	255	1	cancer	cancer	NOUN
bjp-59809	255	2	cell	cell	NOUN
bjp-59809	255	3	.	.	PUNCT
bjp-59809	256	1	2011	2011	NUM
bjp-59809	256	2	;	;	PUNCT
bjp-59809	256	3	20	20	NUM
bjp-59809	256	4	:	:	SYM
bjp-59809	256	5	487	487	NUM
bjp-59809	256	6	-	-	SYM
bjp-59809	256	7	99	99	NUM
bjp-59809	256	8	.	.	PUNCT
bjp-59809	257	1	kozako	kozako	PROPN
bjp-59809	257	2	t	t	PROPN
bjp-59809	257	3	,	,	PUNCT
bjp-59809	257	4	mellini	mellini	PROPN
bjp-59809	257	5	p	p	NOUN
bjp-59809	257	6	,	,	PUNCT
bjp-59809	257	7	ohsugi	ohsugi	PROPN
bjp-59809	257	8	t	t	PROPN
bjp-59809	257	9	,	,	PUNCT
bjp-59809	257	10	aikawa	aikawa	PROPN
bjp-59809	257	11	a	a	PROPN
bjp-59809	257	12	,	,	PUNCT
bjp-59809	257	13	uchida	uchida	PROPN
bjp-59809	257	14	yi	yi	PROPN
bjp-59809	257	15	,	,	PUNCT
bjp-59809	257	16	honda	honda	PROPN
bjp-59809	257	17	si	si	PROPN
bjp-59809	257	18	,	,	PUNCT
bjp-59809	257	19	suzuki	suzuki	PROPN
bjp-59809	257	20	t.	t.	NOUN
bjp-59809	257	21	novel	novel	ADJ
bjp-59809	257	22	small	small	ADJ
bjp-59809	257	23	molecule	molecule	NOUN
bjp-59809	257	24	sirt2	sirt2	NOUN
bjp-59809	257	25	inhibitors	inhibitor	NOUN
bjp-59809	257	26	induce	induce	VERB
bjp-59809	257	27	cell	cell	NOUN
bjp-59809	257	28	death	death	NOUN
bjp-59809	257	29	in	in	ADP
bjp-59809	257	30	leukemic	leukemic	ADJ
bjp-59809	257	31	cell	cell	NOUN
bjp-59809	257	32	lines	line	NOUN
bjp-59809	257	33	.	.	PUNCT
bjp-59809	258	1	bmc	bmc	ADJ
bjp-59809	258	2	cancer	cancer	NOUN
bjp-59809	258	3	.	.	PUNCT
bjp-59809	259	1	2018	2018	NUM
bjp-59809	259	2	;	;	PUNCT
bjp-59809	259	3	18	18	NUM
bjp-59809	259	4	:	:	SYM
bjp-59809	259	5	791	791	NUM
bjp-59809	259	6	.	.	PUNCT
bjp-59809	260	1	li	li	PROPN
bjp-59809	260	2	c	c	PROPN
bjp-59809	260	3	,	,	PUNCT
bjp-59809	260	4	zhou	zhou	PROPN
bjp-59809	260	5	y	y	PROPN
bjp-59809	260	6	,	,	PUNCT
bjp-59809	260	7	kim	kim	PROPN
bjp-59809	260	8	jt	jt	PROPN
bjp-59809	260	9	,	,	PUNCT
bjp-59809	260	10	sengoku	sengoku	PROPN
bjp-59809	260	11	t	t	PROPN
bjp-59809	260	12	,	,	PUNCT
bjp-59809	260	13	alstott	alstott	PROPN
bjp-59809	260	14	mc	mc	PROPN
bjp-59809	260	15	,	,	PUNCT
bjp-59809	260	16	weiss	weiss	PROPN
bjp-59809	260	17	hl	hl	PROPN
bjp-59809	260	18	,	,	PUNCT
bjp-59809	260	19	wang	wang	PROPN
bjp-59809	260	20	q	q	PROPN
bjp-59809	260	21	,	,	PUNCT
bjp-59809	260	22	evers	evers	PROPN
bjp-59809	260	23	bm	bm	PROPN
bjp-59809	260	24	.	.	PUNCT
bjp-59809	261	1	regulation	regulation	NOUN
bjp-59809	261	2	of	of	ADP
bjp-59809	261	3	sirt2	sirt2	PROPN
bjp-59809	261	4	by	by	ADP
bjp-59809	261	5	wnt	wnt	PROPN
bjp-59809	261	6	/	/	SYM
bjp-59809	261	7	β	β	NOUN
bjp-59809	261	8	-	-	ADJ
bjp-59809	261	9	catenin	catenin	ADJ
bjp-59809	261	10	signaling	signal	VERB
bjp-59809	261	11	pathway	pathway	NOUN
bjp-59809	261	12	in	in	ADP
bjp-59809	261	13	colorectal	colorectal	ADJ
bjp-59809	261	14	cancer	cancer	NOUN
bjp-59809	261	15	cells	cell	NOUN
bjp-59809	261	16	.	.	PUNCT
bjp-59809	262	1	biochim	biochim	PROPN
bjp-59809	262	2	biophys	biophy	NOUN
bjp-59809	262	3	acta	acta	PROPN
bjp-59809	262	4	mol	mol	ADP
bjp-59809	262	5	cell	cell	NOUN
bjp-59809	262	6	res	re	NOUN
bjp-59809	262	7	.	.	PUNCT
bjp-59809	262	8	2021	2021	NUM
bjp-59809	262	9	;	;	PUNCT
bjp-59809	262	10	1868	1868	NUM
bjp-59809	262	11	:	:	PUNCT
bjp-59809	262	12	118966	118966	NUM
bjp-59809	262	13	.	.	PUNCT
bjp-59809	263	1	ma	ma	PROPN
bjp-59809	263	2	w	w	PROPN
bjp-59809	263	3	,	,	PUNCT
bjp-59809	263	4	zhao	zhao	PROPN
bjp-59809	263	5	x	x	PROPN
bjp-59809	263	6	,	,	PUNCT
bjp-59809	263	7	wang	wang	PROPN
bjp-59809	263	8	k	k	PROPN
bjp-59809	263	9	,	,	PUNCT
bjp-59809	263	10	liu	liu	PROPN
bjp-59809	263	11	j	j	PROPN
bjp-59809	263	12	,	,	PUNCT
bjp-59809	263	13	huang	huang	PROPN
bjp-59809	263	14	g.	g.	PROPN
bjp-59809	263	15	dichloroacetic	dichloroacetic	PROPN
bjp-59809	263	16	acid	acid	PROPN
bjp-59809	263	17	(	(	PUNCT
bjp-59809	263	18	dca	dca	PROPN
bjp-59809	263	19	)	)	PUNCT
bjp-59809	263	20	synergizes	synergize	VERB
bjp-59809	263	21	with	with	ADP
bjp-59809	263	22	the	the	DET
bjp-59809	263	23	sirt2	sirt2	PROPN
bjp-59809	263	24	inhibitor	inhibitor	NOUN
bjp-59809	263	25	sirtinol	sirtinol	NOUN
bjp-59809	263	26	and	and	CCONJ
bjp-59809	263	27	agk2	agk2	PROPN
bjp-59809	263	28	to	to	PART
bjp-59809	263	29	enhance	enhance	VERB
bjp-59809	263	30	anti	anti	ADJ
bjp-59809	263	31	-	-	ADJ
bjp-59809	263	32	tumor	tumor	ADJ
bjp-59809	263	33	efficacy	efficacy	NOUN
bjp-59809	263	34	in	in	ADP
bjp-59809	263	35	non	non	ADJ
bjp-59809	263	36	-	-	ADJ
bjp-59809	263	37	small	small	ADJ
bjp-59809	263	38	cell	cell	NOUN
bjp-59809	263	39	lung	lung	NOUN
bjp-59809	263	40	cancer	cancer	NOUN
bjp-59809	263	41	.	.	PUNCT
bjp-59809	264	1	cancer	cancer	NOUN
bjp-59809	264	2	biol	biol	PROPN
bjp-59809	264	3	ther	ther	ADV
bjp-59809	264	4	.	.	PUNCT
bjp-59809	265	1	2018	2018	NUM
bjp-59809	265	2	;	;	PUNCT
bjp-59809	265	3	19	19	NUM
bjp-59809	265	4	:	:	SYM
bjp-59809	265	5	835	835	NUM
bjp-59809	265	6	-	-	SYM
bjp-59809	265	7	46	46	NUM
bjp-59809	265	8	.	.	PUNCT
bjp-59809	266	1	morris	morris	PROPN
bjp-59809	266	2	bj	bj	PROPN
bjp-59809	266	3	.	.	PUNCT
bjp-59809	267	1	seven	seven	NUM
bjp-59809	267	2	sirtuins	sirtuin	NOUN
bjp-59809	267	3	for	for	ADP
bjp-59809	267	4	seven	seven	NUM
bjp-59809	267	5	deadly	deadly	ADJ
bjp-59809	267	6	diseases	disease	NOUN
bjp-59809	267	7	of	of	ADP
bjp-59809	267	8	aging	aging	NOUN
bjp-59809	267	9	.	.	PUNCT
bjp-59809	268	1	free	free	ADJ
bjp-59809	268	2	radic	radic	ADJ
bjp-59809	268	3	biol	biol	PROPN
bjp-59809	268	4	med	me	VERB
bjp-59809	268	5	.	.	PUNCT
bjp-59809	269	1	2013	2013	NUM
bjp-59809	269	2	;	;	PUNCT
bjp-59809	269	3	56	56	NUM
bjp-59809	269	4	:	:	SYM
bjp-59809	269	5	133	133	NUM
bjp-59809	269	6	-	-	SYM
bjp-59809	269	7	71	71	NUM
bjp-59809	269	8	.	.	PUNCT
bjp-59809	270	1	peck	peck	PROPN
bjp-59809	270	2	b	b	PROPN
bjp-59809	270	3	,	,	PUNCT
bjp-59809	270	4	chen	chen	PROPN
bjp-59809	270	5	cy	cy	PROPN
bjp-59809	270	6	,	,	PUNCT
bjp-59809	270	7	ho	ho	PROPN
bjp-59809	270	8	kk	kk	PROPN
bjp-59809	270	9	,	,	PUNCT
bjp-59809	270	10	di	di	NOUN
bjp-59809	270	11	fruscia	fruscia	PROPN
bjp-59809	270	12	p	p	X
bjp-59809	270	13	,	,	PUNCT
bjp-59809	270	14	myatt	myatt	PROPN
bjp-59809	270	15	ss	ss	PROPN
bjp-59809	270	16	,	,	PUNCT
bjp-59809	270	17	coombes	coombes	PROPN
bjp-59809	270	18	rc	rc	PROPN
bjp-59809	270	19	,	,	PUNCT
bjp-59809	270	20	fuchter	fuchter	PROPN
bjp-59809	270	21	mj	mj	PROPN
bjp-59809	270	22	,	,	PUNCT
bjp-59809	270	23	hsiao	hsiao	PROPN
bjp-59809	270	24	cd	cd	PROPN
bjp-59809	270	25	,	,	PUNCT
bjp-59809	270	26	lam	lam	PROPN
bjp-59809	270	27	ew	ew	PROPN
bjp-59809	270	28	.	.	PUNCT
bjp-59809	270	29	sirt	sirt	PROPN
bjp-59809	270	30	inhibitors	inhibitor	NOUN
bjp-59809	270	31	induce	induce	VERB
bjp-59809	270	32	cell	cell	NOUN
bjp-59809	270	33	death	death	NOUN
bjp-59809	270	34	and	and	CCONJ
bjp-59809	270	35	p53	p53	NOUN
bjp-59809	270	36	acetylation	acetylation	NOUN
bjp-59809	270	37	through	through	ADP
bjp-59809	270	38	targeting	target	VERB
bjp-59809	270	39	both	both	DET
bjp-59809	270	40	sirt1	sirt1	NOUN
bjp-59809	270	41	and	and	CCONJ
bjp-59809	270	42	sirt2	sirt2	PROPN
bjp-59809	270	43	.	.	PUNCT
bjp-59809	271	1	mol	mol	ADP
bjp-59809	271	2	cancer	cancer	NOUN
bjp-59809	271	3	ther	ther	ADV
bjp-59809	271	4	.	.	PUNCT
bjp-59809	272	1	2010	2010	NUM
bjp-59809	272	2	;	;	PUNCT
bjp-59809	272	3	9	9	NUM
bjp-59809	272	4	:	:	SYM
bjp-59809	272	5	844	844	NUM
bjp-59809	272	6	-	-	SYM
bjp-59809	272	7	55	55	NUM
bjp-59809	272	8	.	.	PUNCT
bjp-59809	273	1	roshdy	roshdy	NOUN
bjp-59809	273	2	e	e	NOUN
bjp-59809	273	3	,	,	PUNCT
bjp-59809	273	4	mustafa	mustafa	PROPN
bjp-59809	273	5	m	m	PROPN
bjp-59809	273	6	,	,	PUNCT
bjp-59809	273	7	shaltout	shaltout	PROPN
bjp-59809	273	8	ae	ae	PROPN
bjp-59809	273	9	,	,	PUNCT
bjp-59809	273	10	radwan	radwan	PROPN
bjp-59809	273	11	mo	mo	PROPN
bjp-59809	273	12	,	,	PUNCT
bjp-59809	273	13	ibrahim	ibrahim	PROPN
bjp-59809	273	14	maa	maa	PROPN
bjp-59809	273	15	,	,	PUNCT
bjp-59809	273	16	soliman	soliman	NOUN
bjp-59809	273	17	me	i	PRON
bjp-59809	273	18	,	,	PUNCT
bjp-59809	273	19	fujita	fujita	PROPN
bjp-59809	273	20	m	m	PROPN
bjp-59809	273	21	,	,	PUNCT
bjp-59809	273	22	otsuka	otsuka	PROPN
bjp-59809	273	23	m	m	PROPN
bjp-59809	273	24	,	,	PUNCT
bjp-59809	273	25	ali	ali	PROPN
bjp-59809	273	26	tfs	tfs	PROPN
bjp-59809	273	27	.	.	PUNCT
bjp-59809	274	1	selective	selective	ADJ
bjp-59809	274	2	sirt2	sirt2	PROPN
bjp-59809	274	3	inhibitors	inhibitor	NOUN
bjp-59809	274	4	as	as	ADP
bjp-59809	274	5	promising	promise	VERB
bjp-59809	274	6	anti	anti	ADJ
bjp-59809	274	7	-	-	ADJ
bjp-59809	274	8	cancer	cancer	ADJ
bjp-59809	274	9	therapeutics	therapeutic	NOUN
bjp-59809	274	10	:	:	PUNCT
bjp-59809	274	11	an	an	DET
bjp-59809	274	12	update	update	NOUN
bjp-59809	274	13	from	from	ADP
bjp-59809	274	14	2016	2016	NUM
bjp-59809	274	15	to	to	ADP
bjp-59809	274	16	2020	2020	NUM
bjp-59809	274	17	.	.	PUNCT
bjp-59809	275	1	eur	eur	PROPN
bjp-59809	275	2	j	j	PROPN
bjp-59809	275	3	med	med	PROPN
bjp-59809	275	4	chem	chem	NOUN
bjp-59809	275	5	.	.	PUNCT
bjp-59809	276	1	2021	2021	NUM
bjp-59809	276	2	;	;	PUNCT
bjp-59809	276	3	224	224	NUM
bjp-59809	276	4	:	:	SYM
bjp-59809	276	5	113709	113709	NUM
bjp-59809	276	6	.	.	PUNCT
bjp-59809	277	1	salami	salami	PROPN
bjp-59809	277	2	r	r	PROPN
bjp-59809	277	3	,	,	PUNCT
bjp-59809	277	4	salami	salami	NOUN
bjp-59809	277	5	m	m	PROPN
bjp-59809	277	6	,	,	PUNCT
bjp-59809	277	7	mafi	mafi	PROPN
bjp-59809	277	8	a	a	PROPN
bjp-59809	277	9	,	,	PUNCT
bjp-59809	277	10	vakili	vakili	ADJ
bjp-59809	277	11	o	o	NOUN
bjp-59809	277	12	,	,	PUNCT
bjp-59809	277	13	asemi	asemi	PROPN
bjp-59809	277	14	z.	z.	PROPN
bjp-59809	277	15	circular	circular	PROPN
bjp-59809	277	16	rnas	rna	NOUN
bjp-59809	277	17	and	and	CCONJ
bjp-59809	277	18	glioblastoma	glioblastoma	NOUN
bjp-59809	277	19	multiforme	multiforme	NOUN
bjp-59809	277	20	:	:	PUNCT
bjp-59809	277	21	focus	focus	VERB
bjp-59809	277	22	on	on	ADP
bjp-59809	277	23	molecular	molecular	ADJ
bjp-59809	277	24	mechanisms	mechanism	NOUN
bjp-59809	277	25	.	.	PUNCT
bjp-59809	278	1	cell	cell	NOUN
bjp-59809	278	2	commun	commun	PROPN
bjp-59809	278	3	signal	signal	PROPN
bjp-59809	278	4	.	.	PUNCT
bjp-59809	279	1	2022	2022	NUM
bjp-59809	279	2	;	;	PUNCT
bjp-59809	279	3	20	20	NUM
bjp-59809	279	4	:	:	SYM
bjp-59809	279	5	13	13	NUM
bjp-59809	279	6	.	.	X
bjp-59809	279	7	shoba	shoba	PROPN
bjp-59809	279	8	b	b	NUM
bjp-59809	279	9	,	,	PUNCT
bjp-59809	279	10	lwin	lwin	PROPN
bjp-59809	279	11	zm	zm	PROPN
bjp-59809	279	12	,	,	PUNCT
bjp-59809	279	13	ling	ling	PROPN
bjp-59809	279	14	ls	ls	PROPN
bjp-59809	279	15	,	,	PUNCT
bjp-59809	279	16	bay	bay	PROPN
bjp-59809	279	17	bh	bh	PROPN
bjp-59809	279	18	,	,	PUNCT
bjp-59809	279	19	yip	yip	PROPN
bjp-59809	279	20	gw	gw	PROPN
bjp-59809	279	21	,	,	PUNCT
bjp-59809	279	22	kumar	kumar	PROPN
bjp-59809	279	23	sd	sd	PROPN
bjp-59809	279	24	.	.	PUNCT
bjp-59809	280	1	function	function	NOUN
bjp-59809	280	2	of	of	ADP
bjp-59809	280	3	sirtuins	sirtuin	NOUN
bjp-59809	280	4	in	in	ADP
bjp-59809	280	5	biological	biological	ADJ
bjp-59809	280	6	tissues	tissue	NOUN
bjp-59809	280	7	.	.	PUNCT
bjp-59809	281	1	anat	anat	PROPN
bjp-59809	281	2	rec	rec	PROPN
bjp-59809	281	3	(	(	PUNCT
bjp-59809	281	4	hoboken	hoboken	PROPN
bjp-59809	281	5	)	)	PUNCT
bjp-59809	281	6	.	.	PUNCT
bjp-59809	282	1	2009	2009	NUM
bjp-59809	282	2	;	;	PUNCT
bjp-59809	282	3	292	292	NUM
bjp-59809	282	4	:	:	SYM
bjp-59809	282	5	536	536	NUM
bjp-59809	282	6	-	-	SYM
bjp-59809	282	7	43	43	NUM
bjp-59809	282	8	.	.	PUNCT
bjp-59809	283	1	singh	singh	PROPN
bjp-59809	283	2	ck	ck	PROPN
bjp-59809	283	3	,	,	PUNCT
bjp-59809	283	4	chhabra	chhabra	VERB
bjp-59809	283	5	g	g	NOUN
bjp-59809	283	6	,	,	PUNCT
bjp-59809	283	7	ndiaye	ndiaye	ADP
bjp-59809	283	8	ma	ma	PROPN
bjp-59809	283	9	,	,	PUNCT
bjp-59809	283	10	garcia	garcia	PROPN
bjp-59809	283	11	-	-	PUNCT
bjp-59809	283	12	peterson	peterson	PROPN
bjp-59809	283	13	lm	lm	PROPN
bjp-59809	283	14	,	,	PUNCT
bjp-59809	283	15	mack	mack	PROPN
bjp-59809	283	16	nj	nj	PROPN
bjp-59809	283	17	,	,	PUNCT
bjp-59809	283	18	ahmad	ahmad	PROPN
bjp-59809	283	19	n.	n.	PROPN
bjp-59809	283	20	the	the	DET
bjp-59809	283	21	role	role	NOUN
bjp-59809	283	22	of	of	ADP
bjp-59809	283	23	sirtuins	sirtuin	NOUN
bjp-59809	283	24	in	in	ADP
bjp-59809	283	25	antioxidant	antioxidant	ADJ
bjp-59809	283	26	and	and	CCONJ
bjp-59809	283	27	redox	redox	ADJ
bjp-59809	283	28	signaling	signal	VERB
bjp-59809	283	29	.	.	PUNCT
bjp-59809	284	1	antioxid	antioxid	NOUN
bjp-59809	284	2	redox	redox	NOUN
bjp-59809	284	3	signal	signal	NOUN
bjp-59809	284	4	.	.	PUNCT
bjp-59809	285	1	2018	2018	NUM
bjp-59809	285	2	;	;	PUNCT
bjp-59809	285	3	28	28	NUM
bjp-59809	285	4	:	:	PUNCT
bjp-59809	285	5	643	643	NUM
bjp-59809	285	6	-	-	SYM
bjp-59809	285	7	61	61	NUM
bjp-59809	285	8	.	.	PUNCT
bjp-59809	286	1	singh	singh	PROPN
bjp-59809	286	2	s	s	PROPN
bjp-59809	286	3	,	,	PUNCT
bjp-59809	286	4	kumar	kumar	PROPN
bjp-59809	286	5	pu	pu	PROPN
bjp-59809	286	6	,	,	PUNCT
bjp-59809	286	7	thakur	thakur	PROPN
bjp-59809	286	8	s	s	PROPN
bjp-59809	286	9	,	,	PUNCT
bjp-59809	286	10	kiran	kiran	PROPN
bjp-59809	286	11	s	s	PROPN
bjp-59809	286	12	,	,	PUNCT
bjp-59809	286	13	sen	sen	PROPN
bjp-59809	286	14	b	b	PROPN
bjp-59809	286	15	,	,	PUNCT
bjp-59809	286	16	sharma	sharma	PROPN
bjp-59809	286	17	s	s	PROPN
bjp-59809	286	18	,	,	PUNCT
bjp-59809	286	19	rao	rao	PROPN
bjp-59809	286	20	bangladesh	bangladesh	PROPN
bjp-59809	286	21	j	j	PROPN
bjp-59809	286	22	pharmacol	pharmacol	PROPN
bjp-59809	286	23	2022	2022	NUM
bjp-59809	286	24	;	;	PUNCT
bjp-59809	286	25	17	17	NUM
bjp-59809	286	26	:	:	SYM
bjp-59809	286	27	42	42	NUM
bjp-59809	286	28	-	-	SYM
bjp-59809	286	29	50	50	NUM
bjp-59809	286	30	49	49	NUM
bjp-59809	286	31	author	author	NOUN
bjp-59809	286	32	info	info	NOUN
bjp-59809	286	33	ebru	ebru	NOUN
bjp-59809	286	34	güçlü	güçlü	NOUN
bjp-59809	286	35	(	(	PUNCT
bjp-59809	286	36	principal	principal	ADJ
bjp-59809	286	37	contact	contact	NOUN
bjp-59809	286	38	)	)	PUNCT
bjp-59809	286	39	e	e	NOUN
bjp-59809	286	40	-	-	NOUN
bjp-59809	286	41	mail	mail	NOUN
bjp-59809	286	42	:	:	PUNCT
bjp-59809	286	43	ebruavc.87@gmail.com	ebruavc.87@gmail.com	PROPN
bjp-59809	286	44	vv	vv	PROPN
bjp-59809	286	45	,	,	PUNCT
bjp-59809	286	46	poongothai	poongothai	PROPN
bjp-59809	286	47	ar	ar	PROPN
bjp-59809	286	48	,	,	PUNCT
bjp-59809	286	49	ramakrishna	ramakrishna	PROPN
bjp-59809	286	50	g.	g.	PROPN
bjp-59809	286	51	expression	expression	NOUN
bjp-59809	286	52	/	/	SYM
bjp-59809	286	53	localization	localization	NOUN
bjp-59809	286	54	patterns	pattern	NOUN
bjp-59809	286	55	of	of	ADP
bjp-59809	286	56	sirtuins	sirtuin	NOUN
bjp-59809	286	57	(	(	PUNCT
bjp-59809	286	58	sirt1	sirt1	NOUN
bjp-59809	286	59	,	,	PUNCT
bjp-59809	286	60	sirt2	sirt2	PROPN
bjp-59809	286	61	,	,	PUNCT
bjp-59809	286	62	and	and	CCONJ
bjp-59809	286	63	sirt7	sirt7	NUM
bjp-59809	286	64	)	)	PUNCT
bjp-59809	286	65	during	during	ADP
bjp-59809	286	66	progression	progression	NOUN
bjp-59809	286	67	of	of	ADP
bjp-59809	286	68	cervical	cervical	ADJ
bjp-59809	286	69	cancer	cancer	NOUN
bjp-59809	286	70	and	and	CCONJ
bjp-59809	286	71	effects	effect	NOUN
bjp-59809	286	72	of	of	ADP
bjp-59809	286	73	sirtuin	sirtuin	NOUN
bjp-59809	286	74	inhibitors	inhibitor	NOUN
bjp-59809	286	75	on	on	ADP
bjp-59809	286	76	growth	growth	NOUN
bjp-59809	286	77	of	of	ADP
bjp-59809	286	78	cervical	cervical	ADJ
bjp-59809	286	79	cancer	cancer	NOUN
bjp-59809	286	80	cells	cell	NOUN
bjp-59809	286	81	.	.	PUNCT
bjp-59809	287	1	tumour	tumour	PROPN
bjp-59809	287	2	biol	biol	PROPN
bjp-59809	287	3	.	.	PUNCT
bjp-59809	288	1	2015	2015	NUM
bjp-59809	288	2	;	;	PUNCT
bjp-59809	288	3	36	36	NUM
bjp-59809	288	4	:	:	SYM
bjp-59809	288	5	6159	6159	NUM
bjp-59809	288	6	-	-	SYM
bjp-59809	288	7	71	71	NUM
bjp-59809	288	8	.	.	PUNCT
bjp-59809	289	1	taylor	taylor	PROPN
bjp-59809	289	2	og	og	PROPN
bjp-59809	289	3	,	,	PUNCT
bjp-59809	289	4	brzozowski	brzozowski	PROPN
bjp-59809	289	5	js	js	PROPN
bjp-59809	289	6	,	,	PUNCT
bjp-59809	289	7	skelding	skelde	VERB
bjp-59809	289	8	ka	ka	PROPN
bjp-59809	289	9	.	.	PROPN
bjp-59809	289	10	glioblastoma	glioblastoma	NOUN
bjp-59809	289	11	multiforme	multiforme	NOUN
bjp-59809	289	12	:	:	PUNCT
bjp-59809	289	13	an	an	DET
bjp-59809	289	14	overview	overview	NOUN
bjp-59809	289	15	of	of	ADP
bjp-59809	289	16	emerging	emerge	VERB
bjp-59809	289	17	therapeutic	therapeutic	ADJ
bjp-59809	289	18	targets	target	NOUN
bjp-59809	289	19	.	.	PUNCT
bjp-59809	290	1	front	front	ADJ
bjp-59809	290	2	oncol	oncol	ADJ
bjp-59809	290	3	.	.	PUNCT
bjp-59809	291	1	2019	2019	NUM
bjp-59809	291	2	;	;	PUNCT
bjp-59809	291	3	9	9	NUM
bjp-59809	291	4	:	:	SYM
bjp-59809	291	5	963	963	NUM
bjp-59809	291	6	.	.	PUNCT
bjp-59809	292	1	villalba	villalba	PROPN
bjp-59809	292	2	jm	jm	PROPN
bjp-59809	292	3	,	,	PUNCT
bjp-59809	292	4	alcaín	alcaín	PROPN
bjp-59809	292	5	fj	fj	PROPN
bjp-59809	292	6	.	.	PUNCT
bjp-59809	292	7	sirtuin	sirtuin	NOUN
bjp-59809	292	8	activators	activator	NOUN
bjp-59809	292	9	and	and	CCONJ
bjp-59809	292	10	inhibitors	inhibitor	NOUN
bjp-59809	292	11	.	.	PUNCT
bjp-59809	293	1	biofactors	biofactor	NOUN
bjp-59809	293	2	2012	2012	NUM
bjp-59809	293	3	;	;	PUNCT
bjp-59809	293	4	38	38	NUM
bjp-59809	293	5	:	:	SYM
bjp-59809	293	6	349	349	NUM
bjp-59809	293	7	-	-	SYM
bjp-59809	293	8	59	59	NUM
bjp-59809	293	9	.	.	PUNCT
bjp-59809	294	1	wang	wang	PROPN
bjp-59809	294	2	w	w	PROPN
bjp-59809	294	3	,	,	PUNCT
bjp-59809	294	4	i	i	PROPN
bjp-59809	294	5	m	m	PROPN
bjp-59809	294	6	j	j	PROPN
bjp-59809	294	7	,	,	PUNCT
bjp-59809	294	8	kim	kim	PROPN
bjp-59809	294	9	s	s	PROPN
bjp-59809	294	10	,	,	PUNCT
bjp-59809	294	11	jang	jang	PROPN
bjp-59809	294	12	s	s	PROPN
bjp-59809	294	13	,	,	PUNCT
bjp-59809	294	14	han	han	PROPN
bjp-59809	294	15	y	y	PROPN
bjp-59809	294	16	,	,	PUNCT
bjp-59809	294	17	yang	yang	PROPN
bjp-59809	294	18	km	km	PROPN
bjp-59809	294	19	,	,	PUNCT
bjp-59809	294	20	kim	kim	PROPN
bjp-59809	294	21	sj	sj	PROPN
bjp-59809	294	22	,	,	PUNCT
bjp-59809	294	23	dhanasekaran	dhanasekaran	PROPN
bjp-59809	294	24	dn	dn	PROPN
bjp-59809	294	25	,	,	PUNCT
bjp-59809	294	26	song	song	NOUN
bjp-59809	294	27	ys	ys	PROPN
bjp-59809	294	28	.	.	PUNCT
bjp-59809	295	1	ros	ros	PROPN
bjp-59809	295	2	-	-	PUNCT
bjp-59809	295	3	induced	induce	VERB
bjp-59809	295	4	sirt2	sirt2	PROPN
bjp-59809	295	5	upregulation	upregulation	NOUN
bjp-59809	295	6	contributes	contribute	VERB
bjp-59809	295	7	to	to	ADP
bjp-59809	295	8	cisplatin	cisplatin	NOUN
bjp-59809	295	9	sensitivity	sensitivity	NOUN
bjp-59809	295	10	in	in	ADP
bjp-59809	295	11	ovarian	ovarian	ADJ
bjp-59809	295	12	cancer	cancer	NOUN
bjp-59809	295	13	.	.	PUNCT
bjp-59809	296	1	antioxidants	antioxidant	NOUN
bjp-59809	296	2	(	(	PUNCT
bjp-59809	296	3	basel	basel	PROPN
bjp-59809	296	4	)	)	PUNCT
bjp-59809	296	5	2020	2020	NUM
bjp-59809	296	6	;	;	PUNCT
bjp-59809	296	7	9	9	NUM
bjp-59809	296	8	:	:	SYM
bjp-59809	296	9	1137	1137	NUM
bjp-59809	296	10	.	.	PUNCT
bjp-59809	297	1	wang	wang	PROPN
bjp-59809	297	2	y	y	PROPN
bjp-59809	297	3	,	,	PUNCT
bjp-59809	297	4	yang	yang	PROPN
bjp-59809	297	5	j	j	PROPN
bjp-59809	297	6	,	,	PUNCT
bjp-59809	297	7	hong	hong	PROPN
bjp-59809	297	8	t	t	PROPN
bjp-59809	297	9	,	,	PUNCT
bjp-59809	297	10	chen	chen	PROPN
bjp-59809	297	11	x	x	PROPN
bjp-59809	297	12	,	,	PUNCT
bjp-59809	297	13	cui	cui	PROPN
bjp-59809	297	14	l.	l.	PROPN
bjp-59809	297	15	sirt2	sirt2	PROPN
bjp-59809	297	16	:	:	PUNCT
bjp-59809	297	17	controversy	controversy	NOUN
bjp-59809	297	18	and	and	CCONJ
bjp-59809	297	19	multiple	multiple	ADJ
bjp-59809	297	20	roles	role	NOUN
bjp-59809	297	21	in	in	ADP
bjp-59809	297	22	disease	disease	NOUN
bjp-59809	297	23	and	and	CCONJ
bjp-59809	297	24	physiology	physiology	NOUN
bjp-59809	297	25	.	.	PUNCT
bjp-59809	298	1	ageing	age	VERB
bjp-59809	298	2	res	re	NOUN
bjp-59809	298	3	rev	rev	PROPN
bjp-59809	298	4	.	.	PROPN
bjp-59809	298	5	2019	2019	NUM
bjp-59809	298	6	;	;	PUNCT
bjp-59809	299	1	55	55	NUM
bjp-59809	299	2	:	:	SYM
bjp-59809	299	3	100961	100961	NUM
bjp-59809	299	4	.	.	PUNCT
bjp-59809	300	1	westphal	westphal	PROPN
bjp-59809	300	2	ch	ch	PROPN
bjp-59809	300	3	,	,	PUNCT
bjp-59809	300	4	dipp	dipp	PROPN
bjp-59809	300	5	ma	ma	PROPN
bjp-59809	300	6	,	,	PUNCT
bjp-59809	300	7	guarente	guarente	PROPN
bjp-59809	300	8	l.	l.	PROPN
bjp-59809	300	9	a	a	DET
bjp-59809	300	10	therapeutic	therapeutic	ADJ
bjp-59809	300	11	role	role	NOUN
bjp-59809	300	12	for	for	ADP
bjp-59809	300	13	sirtuins	sirtuin	NOUN
bjp-59809	300	14	in	in	ADP
bjp-59809	300	15	diseases	disease	NOUN
bjp-59809	300	16	of	of	ADP
bjp-59809	300	17	aging	aging	NOUN
bjp-59809	300	18	?	?	PUNCT
bjp-59809	301	1	trends	trend	NOUN
bjp-59809	301	2	biochem	biochem	PROPN
bjp-59809	301	3	sci	sci	PROPN
bjp-59809	301	4	.	.	PROPN
bjp-59809	301	5	2007	2007	NUM
bjp-59809	301	6	;	;	PUNCT
bjp-59809	301	7	32	32	NUM
bjp-59809	301	8	:	:	SYM
bjp-59809	301	9	555	555	NUM
bjp-59809	301	10	-	-	SYM
bjp-59809	301	11	60	60	NUM
bjp-59809	301	12	.	.	PUNCT
bjp-59809	302	1	wong	wong	PROPN
bjp-59809	302	2	rs	rs	PROPN
bjp-59809	302	3	.	.	PUNCT
bjp-59809	303	1	apoptosis	apoptosis	NOUN
bjp-59809	303	2	in	in	ADP
bjp-59809	303	3	cancer	cancer	NOUN
bjp-59809	303	4	:	:	PUNCT
bjp-59809	303	5	from	from	ADP
bjp-59809	303	6	pathogenesis	pathogenesis	NOUN
bjp-59809	303	7	to	to	ADP
bjp-59809	303	8	treatment	treatment	NOUN
bjp-59809	303	9	.	.	PUNCT
bjp-59809	304	1	j	j	PROPN
bjp-59809	304	2	exp	exp	PROPN
bjp-59809	304	3	clin	clin	PROPN
bjp-59809	304	4	cancer	cancer	NOUN
bjp-59809	304	5	res	re	NOUN
bjp-59809	304	6	.	.	PUNCT
bjp-59809	304	7	2011	2011	NUM
bjp-59809	304	8	;	;	PUNCT
bjp-59809	304	9	30	30	NUM
bjp-59809	304	10	:	:	SYM
bjp-59809	304	11	87	87	NUM
bjp-59809	304	12	.	.	PUNCT
bjp-59809	305	1	xu	xu	PROPN
bjp-59809	306	1	h	h	PROPN
bjp-59809	306	2	,	,	PUNCT
bjp-59809	306	3	li	li	PROPN
bjp-59809	306	4	y	y	PROPN
bjp-59809	306	5	,	,	PUNCT
bjp-59809	306	6	chen	chen	PROPN
bjp-59809	306	7	l	l	PROPN
bjp-59809	306	8	,	,	PUNCT
bjp-59809	306	9	wang	wang	PROPN
bjp-59809	306	10	c	c	PROPN
bjp-59809	306	11	,	,	PUNCT
bjp-59809	306	12	wang	wang	PROPN
bjp-59809	306	13	q	q	PROPN
bjp-59809	306	14	,	,	PUNCT
bjp-59809	306	15	zhang	zhang	PROPN
bjp-59809	306	16	h	h	PROPN
bjp-59809	306	17	,	,	PUNCT
bjp-59809	306	18	lin	lin	PROPN
bjp-59809	306	19	y	y	PROPN
bjp-59809	306	20	,	,	PUNCT
bjp-59809	306	21	li	li	PROPN
bjp-59809	306	22	q	q	PROPN
bjp-59809	306	23	,	,	PUNCT
bjp-59809	306	24	pang	pang	NOUN
bjp-59809	306	25	t.	t.	PROPN
bjp-59809	306	26	sirt2	sirt2	PROPN
bjp-59809	306	27	mediates	mediate	NOUN
bjp-59809	306	28	multidrug	multidrug	VERB
bjp-59809	306	29	resistance	resistance	NOUN
bjp-59809	306	30	in	in	ADP
bjp-59809	306	31	acute	acute	ADJ
bjp-59809	306	32	myelogenous	myelogenous	ADJ
bjp-59809	306	33	leukemia	leukemia	NOUN
bjp-59809	306	34	cells	cell	NOUN
bjp-59809	306	35	via	via	ADP
bjp-59809	306	36	erk1/2	erk1/2	PROPN
bjp-59809	306	37	signaling	signal	VERB
bjp-59809	306	38	pathway	pathway	NOUN
bjp-59809	306	39	.	.	PUNCT
bjp-59809	307	1	int	int	NOUN
bjp-59809	307	2	j	j	PROPN
bjp-59809	307	3	oncol	oncol	ADJ
bjp-59809	307	4	.	.	PUNCT
bjp-59809	308	1	2016	2016	NUM
bjp-59809	308	2	;	;	PUNCT
bjp-59809	308	3	48	48	NUM
bjp-59809	308	4	:	:	PUNCT
bjp-59809	308	5	613	613	NUM
bjp-59809	308	6	-	-	SYM
bjp-59809	308	7	23	23	NUM
bjp-59809	308	8	.	.	PUNCT
bjp-59809	309	1	xu	xu	PROPN
bjp-59809	310	1	w	w	PROPN
bjp-59809	310	2	,	,	PUNCT
bjp-59809	310	3	jiang	jiang	PROPN
bjp-59809	310	4	k	k	PROPN
bjp-59809	310	5	,	,	PUNCT
bjp-59809	310	6	shen	shen	PROPN
bjp-59809	310	7	m	m	PROPN
bjp-59809	310	8	,	,	PUNCT
bjp-59809	310	9	qian	qian	PROPN
bjp-59809	310	10	y	y	PROPN
bjp-59809	310	11	,	,	PUNCT
bjp-59809	310	12	peng	peng	PROPN
bjp-59809	310	13	y.	y.	PROPN
bjp-59809	310	14	sirt2	sirt2	PROPN
bjp-59809	310	15	suppresses	suppress	VERB
bjp-59809	310	16	nonsmall	nonsmall	NOUN
bjp-59809	310	17	cell	cell	NOUN
bjp-59809	310	18	lung	lung	NOUN
bjp-59809	310	19	cancer	cancer	NOUN
bjp-59809	310	20	growth	growth	NOUN
bjp-59809	310	21	by	by	ADP
bjp-59809	310	22	targeting	target	VERB
bjp-59809	310	23	jmjd2a	jmjd2a	PROPN
bjp-59809	310	24	.	.	PUNCT
bjp-59809	311	1	biol	biol	PROPN
bjp-59809	311	2	chem	chem	NOUN
bjp-59809	311	3	.	.	PUNCT
bjp-59809	312	1	2015	2015	NUM
bjp-59809	312	2	;	;	PUNCT
bjp-59809	312	3	396	396	NUM
bjp-59809	312	4	:	:	PUNCT
bjp-59809	312	5	929	929	NUM
bjp-59809	312	6	-	-	SYM
bjp-59809	312	7	36	36	NUM
bjp-59809	312	8	.	.	PUNCT
bjp-59809	313	1	yamamoto	yamamoto	PROPN
bjp-59809	313	2	h	h	PROPN
bjp-59809	313	3	,	,	PUNCT
bjp-59809	313	4	schoonjans	schoonjan	VERB
bjp-59809	313	5	k	k	PROPN
bjp-59809	313	6	,	,	PUNCT
bjp-59809	313	7	auwerx	auwerx	PROPN
bjp-59809	313	8	j.	j.	PROPN
bjp-59809	313	9	sirtuin	sirtuin	PROPN
bjp-59809	313	10	functions	function	NOUN
bjp-59809	313	11	in	in	ADP
bjp-59809	313	12	health	health	NOUN
bjp-59809	313	13	and	and	CCONJ
bjp-59809	313	14	disease	disease	NOUN
bjp-59809	313	15	.	.	PUNCT
bjp-59809	314	1	mol	mol	ADP
bjp-59809	314	2	endocrinol	endocrinol	NOUN
bjp-59809	314	3	.	.	PUNCT
bjp-59809	315	1	2007	2007	NUM
bjp-59809	315	2	;	;	PUNCT
bjp-59809	315	3	21	21	NUM
bjp-59809	315	4	:	:	PUNCT
bjp-59809	315	5	1745	1745	NUM
bjp-59809	315	6	-	-	SYM
bjp-59809	315	7	55	55	NUM
bjp-59809	315	8	.	.	PUNCT
bjp-59809	316	1	zhang	zhang	PROPN
bjp-59809	316	2	gz	gz	PROPN
bjp-59809	316	3	,	,	PUNCT
bjp-59809	316	4	deng	deng	PROPN
bjp-59809	316	5	yj	yj	PROPN
bjp-59809	316	6	,	,	PUNCT
bjp-59809	316	7	xie	xie	PROPN
bjp-59809	316	8	qq	qq	PROPN
bjp-59809	316	9	,	,	PUNCT
bjp-59809	316	10	ren	ren	PROPN
bjp-59809	316	11	eh	eh	INTJ
bjp-59809	316	12	,	,	PUNCT
bjp-59809	316	13	ma	ma	PROPN
bjp-59809	316	14	zj	zj	PROPN
bjp-59809	316	15	,	,	PUNCT
bjp-59809	316	16	he	he	PRON
bjp-59809	316	17	xg	xg	VERB
bjp-59809	316	18	,	,	PUNCT
bjp-59809	316	19	gao	gao	PROPN
bjp-59809	316	20	yc	yc	PROPN
bjp-59809	316	21	,	,	PUNCT
bjp-59809	316	22	kang	kang	PROPN
bjp-59809	316	23	xw	xw	PROPN
bjp-59809	316	24	.	.	PUNCT
bjp-59809	316	25	sirtuins	sirtuin	NOUN
bjp-59809	316	26	and	and	CCONJ
bjp-59809	316	27	intervertebral	intervertebral	ADJ
bjp-59809	316	28	disc	disc	NOUN
bjp-59809	316	29	degeneration	degeneration	NOUN
bjp-59809	316	30	:	:	PUNCT
bjp-59809	316	31	roles	role	NOUN
bjp-59809	316	32	in	in	ADP
bjp-59809	316	33	inflammation	inflammation	NOUN
bjp-59809	316	34	,	,	PUNCT
bjp-59809	316	35	oxidative	oxidative	ADJ
bjp-59809	316	36	stress	stress	NOUN
bjp-59809	316	37	,	,	PUNCT
bjp-59809	316	38	and	and	CCONJ
bjp-59809	316	39	mitochondrial	mitochondrial	ADJ
bjp-59809	316	40	function	function	NOUN
bjp-59809	316	41	.	.	PUNCT
bjp-59809	317	1	clin	clin	PROPN
bjp-59809	317	2	chim	chim	PROPN
bjp-59809	317	3	acta	acta	PROPN
bjp-59809	317	4	.	.	PUNCT
bjp-59809	318	1	2020	2020	NUM
bjp-59809	318	2	;	;	PUNCT
bjp-59809	318	3	508	508	NUM
bjp-59809	318	4	:	:	PUNCT
bjp-59809	318	5	33	33	NUM
bjp-59809	318	6	-	-	SYM
bjp-59809	318	7	42	42	NUM
bjp-59809	318	8	.	.	PUNCT
bjp-59809	319	1	zhang	zhang	PROPN
bjp-59809	319	2	jh	jh	PROPN
bjp-59809	319	3	,	,	PUNCT
bjp-59809	319	4	xu	xu	PROPN
bjp-59809	319	5	m.	m.	PROPN
bjp-59809	319	6	dna	dna	PROPN
bjp-59809	319	7	fragmentation	fragmentation	NOUN
bjp-59809	319	8	in	in	ADP
bjp-59809	319	9	apoptosis	apoptosis	NOUN
bjp-59809	319	10	.	.	PUNCT
bjp-59809	320	1	cell	cell	NOUN
bjp-59809	320	2	res	re	NOUN
bjp-59809	320	3	.	.	PUNCT
bjp-59809	320	4	2000	2000	NUM
bjp-59809	320	5	;	;	PUNCT
bjp-59809	320	6	10	10	NUM
bjp-59809	320	7	:	:	SYM
bjp-59809	320	8	205	205	NUM
bjp-59809	320	9	-	-	SYM
bjp-59809	320	10	11	11	NUM
bjp-59809	320	11	.	.	PUNCT
bjp-59809	321	1	zhu	zhu	PROPN
bjp-59809	321	2	s	s	PART
bjp-59809	321	3	,	,	PUNCT
bjp-59809	321	4	dong	dong	PROPN
bjp-59809	321	5	z	z	PROPN
bjp-59809	321	6	,	,	PUNCT
bjp-59809	321	7	ke	ke	PROPN
bjp-59809	321	8	x	x	PROPN
bjp-59809	321	9	,	,	PUNCT
bjp-59809	321	10	hou	hou	PROPN
bjp-59809	321	11	j	j	PROPN
bjp-59809	321	12	,	,	PUNCT
bjp-59809	321	13	zhao	zhao	PROPN
bjp-59809	321	14	e	e	PROPN
bjp-59809	321	15	,	,	PUNCT
bjp-59809	321	16	zhang	zhang	PROPN
bjp-59809	321	17	k	k	PROPN
bjp-59809	321	18	,	,	PUNCT
bjp-59809	321	19	wang	wang	PROPN
bjp-59809	321	20	f	f	PROPN
bjp-59809	321	21	,	,	PUNCT
bjp-59809	321	22	yang	yang	PROPN
bjp-59809	321	23	l	l	PROPN
bjp-59809	321	24	,	,	PUNCT
bjp-59809	321	25	xiang	xiang	PROPN
bjp-59809	321	26	z	z	PROPN
bjp-59809	321	27	,	,	PUNCT
bjp-59809	321	28	cui	cui	PROPN
bjp-59809	321	29	h.	h.	PROPN
bjp-59809	321	30	the	the	DET
bjp-59809	321	31	roles	role	NOUN
bjp-59809	321	32	of	of	ADP
bjp-59809	321	33	sirtuins	sirtuin	NOUN
bjp-59809	321	34	family	family	NOUN
bjp-59809	321	35	in	in	ADP
bjp-59809	321	36	cell	cell	NOUN
bjp-59809	321	37	metabolism	metabolism	NOUN
bjp-59809	321	38	during	during	ADP
bjp-59809	321	39	tumor	tumor	NOUN
bjp-59809	321	40	development	development	NOUN
bjp-59809	321	41	.	.	PUNCT
bjp-59809	322	1	semin	semin	PROPN
bjp-59809	322	2	cancer	cancer	PROPN
bjp-59809	322	3	biol	biol	PROPN
bjp-59809	322	4	.	.	PUNCT
bjp-59809	323	1	2019	2019	NUM
bjp-59809	323	2	;	;	PUNCT
bjp-59809	323	3	57	57	NUM
bjp-59809	323	4	:	:	SYM
bjp-59809	323	5	59	59	NUM
bjp-59809	323	6	-	-	SYM
bjp-59809	323	7	71	71	NUM
bjp-59809	323	8	.	.	X
bjp-59809	323	9	50	50	NUM
bjp-59809	323	10	bangladesh	bangladesh	NOUN
bjp-59809	323	11	j	j	PROPN
bjp-59809	323	12	pharmacol	pharmacol	PROPN
bjp-59809	323	13	2022	2022	NUM
bjp-59809	323	14	;	;	PUNCT
bjp-59809	323	15	17	17	NUM
bjp-59809	323	16	:	:	SYM
bjp-59809	323	17	42	42	NUM
bjp-59809	323	18	-	-	SYM
bjp-59809	323	19	50	50	NUM