id	sid	tid	token	lemma	pos
bjp-69267	1	1	bangladesh	bangladesh	PROPN
bjp-69267	1	2	journal	journal	PROPN
bjp-69267	1	3	of	of	ADP
bjp-69267	1	4	pharmacology	pharmacology	NOUN
bjp-69267	1	5	research	research	NOUN
bjp-69267	1	6	article	article	NOUN
bjp-69267	1	7	bjp	bjp	NOUN
bjp-69267	1	8	introduction	introduction	NOUN
bjp-69267	1	9	microorganisms	microorganism	NOUN
bjp-69267	1	10	have	have	VERB
bjp-69267	1	11	a	a	DET
bjp-69267	1	12	profound	profound	ADJ
bjp-69267	1	13	impact	impact	NOUN
bjp-69267	1	14	on	on	ADP
bjp-69267	1	15	the	the	DET
bjp-69267	1	16	world	world	NOUN
bjp-69267	1	17	,	,	PUNCT
bjp-69267	1	18	affecting	affect	VERB
bjp-69267	1	19	food	food	NOUN
bjp-69267	1	20	cycles	cycle	NOUN
bjp-69267	1	21	and	and	CCONJ
bjp-69267	1	22	human	human	ADJ
bjp-69267	1	23	health	health	NOUN
bjp-69267	1	24	.	.	PUNCT
bjp-69267	2	1	within	within	ADP
bjp-69267	2	2	their	their	PRON
bjp-69267	2	3	realm	realm	NOUN
bjp-69267	2	4	,	,	PUNCT
bjp-69267	2	5	both	both	DET
bjp-69267	2	6	non	non	ADJ
bjp-69267	2	7	-	-	ADJ
bjp-69267	2	8	pathogenic	pathogenic	ADJ
bjp-69267	2	9	and	and	CCONJ
bjp-69267	2	10	pathogenic	pathogenic	ADJ
bjp-69267	2	11	strains	strain	NOUN
bjp-69267	2	12	exist	exist	VERB
bjp-69267	2	13	,	,	PUNCT
bjp-69267	2	14	each	each	PRON
bjp-69267	2	15	with	with	ADP
bjp-69267	2	16	distinct	distinct	ADJ
bjp-69267	2	17	effects	effect	NOUN
bjp-69267	2	18	on	on	ADP
bjp-69267	2	19	living	live	VERB
bjp-69267	2	20	organisms	organism	NOUN
bjp-69267	2	21	(	(	PUNCT
bjp-69267	2	22	wan‐mohtar	wan‐mohtar	NOUN
bjp-69267	2	23	et	et	PROPN
bjp-69267	2	24	al	al	PROPN
bjp-69267	2	25	.	.	PROPN
bjp-69267	2	26	,	,	PUNCT
bjp-69267	2	27	2022	2022	NUM
bjp-69267	2	28	)	)	PUNCT
bjp-69267	2	29	.	.	PUNCT
bjp-69267	3	1	non	non	ADJ
bjp-69267	3	2	-	-	ADJ
bjp-69267	3	3	pathogenic	pathogenic	ADJ
bjp-69267	3	4	microorganisms	microorganism	NOUN
bjp-69267	3	5	are	be	AUX
bjp-69267	3	6	essential	essential	ADJ
bjp-69267	3	7	for	for	ADP
bjp-69267	3	8	ecological	ecological	ADJ
bjp-69267	3	9	processes	process	NOUN
bjp-69267	3	10	,	,	PUNCT
bjp-69267	3	11	nutrient	nutrient	ADJ
bjp-69267	3	12	cycling	cycling	NOUN
bjp-69267	3	13	,	,	PUNCT
bjp-69267	3	14	and	and	CCONJ
bjp-69267	3	15	symbiotic	symbiotic	ADJ
bjp-69267	3	16	relationships	relationship	NOUN
bjp-69267	3	17	that	that	PRON
bjp-69267	3	18	aid	aid	VERB
bjp-69267	3	19	digestion	digestion	NOUN
bjp-69267	3	20	and	and	CCONJ
bjp-69267	3	21	vitamin	vitamin	NOUN
bjp-69267	3	22	synthesis	synthesis	NOUN
bjp-69267	3	23	,	,	PUNCT
bjp-69267	3	24	highlighting	highlight	VERB
bjp-69267	3	25	their	their	PRON
bjp-69267	3	26	vital	vital	ADJ
bjp-69267	3	27	role	role	NOUN
bjp-69267	3	28	in	in	ADP
bjp-69267	3	29	sustaining	sustain	VERB
bjp-69267	3	30	life	life	NOUN
bjp-69267	3	31	(	(	PUNCT
bjp-69267	3	32	daisley	daisley	NOUN
bjp-69267	3	33	et	et	PROPN
bjp-69267	3	34	al	al	PROPN
bjp-69267	3	35	.	.	PROPN
bjp-69267	3	36	,	,	PUNCT
bjp-69267	3	37	2021	2021	NUM
bjp-69267	3	38	)	)	PUNCT
bjp-69267	3	39	.	.	PUNCT
bjp-69267	4	1	on	on	ADP
bjp-69267	4	2	the	the	DET
bjp-69267	4	3	other	other	ADJ
bjp-69267	4	4	hand	hand	NOUN
bjp-69267	4	5	,	,	PUNCT
bjp-69267	4	6	pathogenic	pathogenic	ADJ
bjp-69267	4	7	microorganisms	microorganism	NOUN
bjp-69267	4	8	can	can	AUX
bjp-69267	4	9	cause	cause	VERB
bjp-69267	4	10	infectious	infectious	ADJ
bjp-69267	4	11	diseases	disease	NOUN
bjp-69267	4	12	by	by	ADP
bjp-69267	4	13	exploiting	exploit	VERB
bjp-69267	4	14	human	human	ADJ
bjp-69267	4	15	immune	immune	ADJ
bjp-69267	4	16	system	system	NOUN
bjp-69267	4	17	vulnerabilities	vulnerabilitie	VERB
bjp-69267	4	18	.	.	PUNCT
bjp-69267	5	1	to	to	PART
bjp-69267	5	2	combat	combat	VERB
bjp-69267	5	3	them	they	PRON
bjp-69267	5	4	,	,	PUNCT
bjp-69267	5	5	antimicrobial	antimicrobial	ADJ
bjp-69267	5	6	agents	agent	NOUN
bjp-69267	5	7	like	like	ADP
bjp-69267	5	8	antibacterials	antibacterial	NOUN
bjp-69267	5	9	,	,	PUNCT
bjp-69267	5	10	antivirals	antiviral	NOUN
bjp-69267	5	11	,	,	PUNCT
bjp-69267	5	12	and	and	CCONJ
bjp-69267	5	13	antifungals	antifungal	NOUN
bjp-69267	5	14	have	have	AUX
bjp-69267	5	15	been	be	AUX
bjp-69267	5	16	developed	develop	VERB
bjp-69267	5	17	.	.	PUNCT
bjp-69267	6	1	unfortunately	unfortunately	ADV
bjp-69267	6	2	,	,	PUNCT
bjp-69267	6	3	the	the	DET
bjp-69267	6	4	improper	improper	ADJ
bjp-69267	6	5	use	use	NOUN
bjp-69267	6	6	and	and	CCONJ
bjp-69267	6	7	excessive	excessive	ADJ
bjp-69267	6	8	utilization	utilization	NOUN
bjp-69267	6	9	of	of	ADP
bjp-69267	6	10	antimicrobial	antimicrobial	ADJ
bjp-69267	6	11	agents	agent	NOUN
bjp-69267	6	12	have	have	AUX
bjp-69267	6	13	led	lead	VERB
bjp-69267	6	14	to	to	ADP
bjp-69267	6	15	a	a	DET
bjp-69267	6	16	pressing	press	VERB
bjp-69267	6	17	issue	issue	NOUN
bjp-69267	6	18	:	:	PUNCT
bjp-69267	6	19	the	the	DET
bjp-69267	6	20	emergence	emergence	NOUN
bjp-69267	6	21	of	of	ADP
bjp-69267	6	22	antimicrobial	antimicrobial	ADJ
bjp-69267	6	23	resistance	resistance	NOUN
bjp-69267	6	24	(	(	PUNCT
bjp-69267	6	25	li	li	PROPN
bjp-69267	6	26	and	and	CCONJ
bjp-69267	6	27	webster	webster	PROPN
bjp-69267	6	28	,	,	PUNCT
bjp-69267	6	29	2018	2018	NUM
bjp-69267	6	30	)	)	PUNCT
bjp-69267	6	31	.	.	PUNCT
bjp-69267	7	1	the	the	DET
bjp-69267	7	2	rise	rise	NOUN
bjp-69267	7	3	of	of	ADP
bjp-69267	7	4	emerging	emerge	VERB
bjp-69267	7	5	and	and	CCONJ
bjp-69267	7	6	reemerging	reemerge	VERB
bjp-69267	7	7	diseases	disease	NOUN
bjp-69267	7	8	presents	present	VERB
bjp-69267	7	9	a	a	DET
bjp-69267	7	10	formidable	formidable	ADJ
bjp-69267	7	11	challenge	challenge	NOUN
bjp-69267	7	12	,	,	PUNCT
bjp-69267	7	13	compelling	compelling	ADJ
bjp-69267	7	14	scientists	scientist	NOUN
bjp-69267	7	15	to	to	PART
bjp-69267	7	16	urgently	urgently	ADV
bjp-69267	7	17	search	search	VERB
bjp-69267	7	18	for	for	ADP
bjp-69267	7	19	new	new	ADJ
bjp-69267	7	20	antimicrobial	antimicrobial	ADJ
bjp-69267	7	21	treatment	treatment	NOUN
bjp-69267	7	22	to	to	PART
bjp-69267	7	23	address	address	VERB
bjp-69267	7	24	resistant	resistant	ADJ
bjp-69267	7	25	microorganisms	microorganism	NOUN
bjp-69267	7	26	(	(	PUNCT
bjp-69267	7	27	aslam	aslam	PROPN
bjp-69267	7	28	et	et	PROPN
bjp-69267	7	29	al	al	PROPN
bjp-69267	7	30	.	.	PROPN
bjp-69267	7	31	,	,	PUNCT
bjp-69267	7	32	2018	2018	NUM
bjp-69267	7	33	)	)	PUNCT
bjp-69267	7	34	.	.	PUNCT
bjp-69267	8	1	the	the	DET
bjp-69267	8	2	search	search	NOUN
bjp-69267	8	3	for	for	ADP
bjp-69267	8	4	highly	highly	ADV
bjp-69267	8	5	potent	potent	ADJ
bjp-69267	8	6	molecules	molecule	NOUN
bjp-69267	8	7	with	with	ADP
bjp-69267	8	8	exceptional	exceptional	ADJ
bjp-69267	8	9	therapeutic	therapeutic	ADJ
bjp-69267	8	10	potential	potential	NOUN
bjp-69267	8	11	is	be	AUX
bjp-69267	8	12	increasing	increase	VERB
bjp-69267	8	13	(	(	PUNCT
bjp-69267	8	14	chen	chen	PROPN
bjp-69267	8	15	and	and	CCONJ
bjp-69267	8	16	bajorath	bajorath	PROPN
bjp-69267	8	17	,	,	PUNCT
bjp-69267	8	18	2023	2023	NUM
bjp-69267	8	19	)	)	PUNCT
bjp-69267	8	20	.	.	PUNCT
bjp-69267	9	1	among	among	ADP
bjp-69267	9	2	these	these	PRON
bjp-69267	9	3	,	,	PUNCT
bjp-69267	9	4	pyrazole	pyrazole	NOUN
bjp-69267	9	5	derivatives	derivative	NOUN
bjp-69267	9	6	have	have	AUX
bjp-69267	9	7	emerged	emerge	VERB
bjp-69267	9	8	as	as	ADP
bjp-69267	9	9	a	a	DET
bjp-69267	9	10	fascinating	fascinating	ADJ
bjp-69267	9	11	chemical	chemical	NOUN
bjp-69267	9	12	entity	entity	NOUN
bjp-69267	9	13	with	with	ADP
bjp-69267	9	14	diverse	diverse	ADJ
bjp-69267	9	15	biological	biological	ADJ
bjp-69267	9	16	activities	activity	NOUN
bjp-69267	9	17	and	and	CCONJ
bjp-69267	9	18	great	great	ADJ
bjp-69267	9	19	promise	promise	NOUN
bjp-69267	9	20	for	for	ADP
bjp-69267	9	21	drug	drug	NOUN
bjp-69267	9	22	development	development	NOUN
bjp-69267	9	23	(	(	PUNCT
bjp-69267	9	24	brown	brown	ADJ
bjp-69267	9	25	,	,	PUNCT
bjp-69267	9	26	2018	2018	NUM
bjp-69267	9	27	)	)	PUNCT
bjp-69267	9	28	.	.	PUNCT
bjp-69267	10	1	their	their	PRON
bjp-69267	10	2	unique	unique	ADJ
bjp-69267	10	3	molecular	molecular	ADJ
bjp-69267	10	4	structures	structure	NOUN
bjp-69267	10	5	and	and	CCONJ
bjp-69267	10	6	wide	wide	ADJ
bjp-69267	10	7	range	range	NOUN
bjp-69267	10	8	of	of	ADP
bjp-69267	10	9	biological	biological	ADJ
bjp-69267	10	10	properties	property	NOUN
bjp-69267	10	11	have	have	AUX
bjp-69267	10	12	attracted	attract	VERB
bjp-69267	10	13	attention	attention	NOUN
bjp-69267	10	14	in	in	ADP
bjp-69267	10	15	the	the	DET
bjp-69267	10	16	field	field	NOUN
bjp-69267	10	17	of	of	ADP
bjp-69267	10	18	medicinal	medicinal	ADJ
bjp-69267	10	19	chemistry	chemistry	NOUN
bjp-69267	10	20	,	,	PUNCT
bjp-69267	10	21	making	make	VERB
bjp-69267	10	22	them	they	PRON
bjp-69267	10	23	a	a	DET
bjp-69267	10	24	abstract	abstract	ADJ
bjp-69267	10	25	this	this	DET
bjp-69267	10	26	study	study	NOUN
bjp-69267	10	27	presents	present	VERB
bjp-69267	10	28	the	the	DET
bjp-69267	10	29	synthesis	synthesis	NOUN
bjp-69267	10	30	,	,	PUNCT
bjp-69267	10	31	characterization	characterization	NOUN
bjp-69267	10	32	,	,	PUNCT
bjp-69267	10	33	and	and	CCONJ
bjp-69267	10	34	antimicrobial	antimicrobial	ADJ
bjp-69267	10	35	efficacy	efficacy	NOUN
bjp-69267	10	36	of	of	ADP
bjp-69267	10	37	a	a	DET
bjp-69267	10	38	novel	novel	ADJ
bjp-69267	10	39	pyrazoline	pyrazoline	NOUN
bjp-69267	10	40	carboxamide	carboxamide	NOUN
bjp-69267	10	41	heterocyclic	heterocyclic	ADJ
bjp-69267	10	42	compound	compound	PROPN
bjp-69267	10	43	.	.	PUNCT
bjp-69267	11	1	synthesized	synthesize	VERB
bjp-69267	11	2	through	through	ADP
bjp-69267	11	3	a	a	DET
bjp-69267	11	4	two	two	NUM
bjp-69267	11	5	-	-	PUNCT
bjp-69267	11	6	step	step	NOUN
bjp-69267	11	7	process	process	NOUN
bjp-69267	11	8	,	,	PUNCT
bjp-69267	11	9	involving	involve	VERB
bjp-69267	11	10	the	the	DET
bjp-69267	11	11	formation	formation	NOUN
bjp-69267	11	12	of	of	ADP
bjp-69267	11	13	an	an	DET
bjp-69267	11	14	α	α	NOUN
bjp-69267	11	15	,	,	PUNCT
bjp-69267	11	16	β	β	ADJ
bjp-69267	11	17	-	-	ADJ
bjp-69267	11	18	unsaturated	unsaturated	ADJ
bjp-69267	11	19	ketone	ketone	NOUN
bjp-69267	11	20	and	and	CCONJ
bjp-69267	11	21	subsequent	subsequent	ADJ
bjp-69267	11	22	conversion	conversion	NOUN
bjp-69267	11	23	into	into	ADP
bjp-69267	11	24	a	a	DET
bjp-69267	11	25	pyrazoline	pyrazoline	NOUN
bjp-69267	11	26	carboxamide	carboxamide	NOUN
bjp-69267	11	27	derivative	derivative	NOUN
bjp-69267	11	28	,	,	PUNCT
bjp-69267	11	29	the	the	DET
bjp-69267	11	30	compound	compound	NOUN
bjp-69267	11	31	's	's	PART
bjp-69267	11	32	structure	structure	NOUN
bjp-69267	11	33	and	and	CCONJ
bjp-69267	11	34	functional	functional	ADJ
bjp-69267	11	35	groups	group	NOUN
bjp-69267	11	36	were	be	AUX
bjp-69267	11	37	confirmed	confirm	VERB
bjp-69267	11	38	using	use	VERB
bjp-69267	11	39	ft	ft	PROPN
bjp-69267	11	40	-	-	PUNCT
bjp-69267	11	41	ir	ir	PROPN
bjp-69267	11	42	,	,	PUNCT
bjp-69267	11	43	1h	1h	NUM
bjp-69267	11	44	nmr	nmr	NOUN
bjp-69267	11	45	,	,	PUNCT
bjp-69267	11	46	and	and	CCONJ
bjp-69267	11	47	dept-135	dept-135	VERB
bjp-69267	11	48	techniques	technique	NOUN
bjp-69267	11	49	.	.	PUNCT
bjp-69267	12	1	the	the	DET
bjp-69267	12	2	compound	compound	NOUN
bjp-69267	12	3	demonstrated	demonstrate	VERB
bjp-69267	12	4	high	high	ADJ
bjp-69267	12	5	purity	purity	NOUN
bjp-69267	12	6	and	and	CCONJ
bjp-69267	12	7	yield	yield	NOUN
bjp-69267	12	8	,	,	PUNCT
bjp-69267	12	9	displaying	display	VERB
bjp-69267	12	10	significant	significant	ADJ
bjp-69267	12	11	inhibitory	inhibitory	ADJ
bjp-69267	12	12	zones	zone	NOUN
bjp-69267	12	13	against	against	ADP
bjp-69267	12	14	microorganisms	microorganism	NOUN
bjp-69267	12	15	,	,	PUNCT
bjp-69267	12	16	notably	notably	ADV
bjp-69267	12	17	listeria	listeria	VERB
bjp-69267	12	18	monocytogenes	monocytogene	NOUN
bjp-69267	12	19	(	(	PUNCT
bjp-69267	12	20	14.2	14.2	NUM
bjp-69267	12	21	±	±	NUM
bjp-69267	12	22	0.0	0.0	NUM
bjp-69267	12	23	mm	mm	NOUN
bjp-69267	12	24	to	to	ADP
bjp-69267	12	25	16.8	16.8	NUM
bjp-69267	12	26	±	±	NUM
bjp-69267	12	27	1.3	1.3	NUM
bjp-69267	12	28	mm	mm	NOUN
bjp-69267	12	29	)	)	PUNCT
bjp-69267	12	30	and	and	CCONJ
bjp-69267	12	31	candida	candida	PROPN
bjp-69267	12	32	albicans	albican	NOUN
bjp-69267	12	33	(	(	PUNCT
bjp-69267	12	34	10.9	10.9	NUM
bjp-69267	12	35	±	±	NUM
bjp-69267	12	36	0.6	0.6	NUM
bjp-69267	12	37	mm	mm	NOUN
bjp-69267	12	38	to	to	ADP
bjp-69267	12	39	17.8	17.8	NUM
bjp-69267	12	40	±	±	NUM
bjp-69267	12	41	1.5	1.5	NUM
bjp-69267	12	42	mm	mm	NOUN
bjp-69267	12	43	)	)	PUNCT
bjp-69267	12	44	.	.	PUNCT
bjp-69267	13	1	evaluation	evaluation	NOUN
bjp-69267	13	2	of	of	ADP
bjp-69267	13	3	drug	drug	NOUN
bjp-69267	13	4	-	-	PUNCT
bjp-69267	13	5	likeness	likeness	NOUN
bjp-69267	13	6	and	and	CCONJ
bjp-69267	13	7	toxicity	toxicity	NOUN
bjp-69267	13	8	highlighted	highlight	VERB
bjp-69267	13	9	its	its	PRON
bjp-69267	13	10	potential	potential	NOUN
bjp-69267	13	11	for	for	ADP
bjp-69267	13	12	drug	drug	NOUN
bjp-69267	13	13	development	development	NOUN
bjp-69267	13	14	.	.	PUNCT
bjp-69267	14	1	molecular	molecular	ADJ
bjp-69267	14	2	docking	docking	NOUN
bjp-69267	14	3	studies	study	NOUN
bjp-69267	14	4	indicated	indicate	VERB
bjp-69267	14	5	strong	strong	ADJ
bjp-69267	14	6	binding	bind	VERB
bjp-69267	14	7	affinities	affinity	NOUN
bjp-69267	14	8	to	to	ADP
bjp-69267	14	9	key	key	ADJ
bjp-69267	14	10	antimicrobial	antimicrobial	ADJ
bjp-69267	14	11	target	target	NOUN
bjp-69267	14	12	proteins	protein	NOUN
bjp-69267	14	13	,	,	PUNCT
bjp-69267	14	14	including	include	VERB
bjp-69267	14	15	dna	dna	PROPN
bjp-69267	14	16	gyrase	gyrase	NOUN
bjp-69267	14	17	,	,	PUNCT
bjp-69267	14	18	penicillin	penicillin	NOUN
bjp-69267	14	19	-	-	PUNCT
bjp-69267	14	20	binding	bind	VERB
bjp-69267	14	21	protein	protein	NOUN
bjp-69267	14	22	,	,	PUNCT
bjp-69267	14	23	and	and	CCONJ
bjp-69267	14	24	c.	c.	NOUN
bjp-69267	14	25	albicans	albican	NOUN
bjp-69267	14	26	sterol	sterol	NOUN
bjp-69267	14	27	14	14	NUM
bjp-69267	14	28	-	-	PUNCT
bjp-69267	14	29	α	α	PRON
bjp-69267	14	30	-	-	NOUN
bjp-69267	14	31	demethylase	demethylase	NOUN
bjp-69267	14	32	.	.	PUNCT
bjp-69267	15	1	molecular	molecular	ADJ
bjp-69267	15	2	dynamics	dynamic	NOUN
bjp-69267	15	3	simulations	simulation	NOUN
bjp-69267	15	4	revealed	reveal	VERB
bjp-69267	15	5	the	the	DET
bjp-69267	15	6	compound	compound	NOUN
bjp-69267	15	7	's	's	PART
bjp-69267	15	8	structural	structural	ADJ
bjp-69267	15	9	flexibility	flexibility	NOUN
bjp-69267	15	10	.	.	PUNCT
bjp-69267	16	1	these	these	DET
bjp-69267	16	2	results	result	NOUN
bjp-69267	16	3	make	make	VERB
bjp-69267	16	4	this	this	DET
bjp-69267	16	5	new	new	ADJ
bjp-69267	16	6	compound	compound	NOUN
bjp-69267	16	7	a	a	DET
bjp-69267	16	8	candidate	candidate	NOUN
bjp-69267	16	9	for	for	ADP
bjp-69267	16	10	further	further	ADJ
bjp-69267	16	11	exploration	exploration	NOUN
bjp-69267	16	12	in	in	ADP
bjp-69267	16	13	drug	drug	NOUN
bjp-69267	16	14	development	development	NOUN
bjp-69267	16	15	,	,	PUNCT
bjp-69267	16	16	highlighting	highlight	VERB
bjp-69267	16	17	its	its	PRON
bjp-69267	16	18	potential	potential	ADJ
bjp-69267	16	19	therapeutic	therapeutic	ADJ
bjp-69267	16	20	applications	application	NOUN
bjp-69267	16	21	.	.	PUNCT
bjp-69267	17	1	article	article	NOUN
bjp-69267	17	2	info	info	NOUN
bjp-69267	17	3	received	receive	VERB
bjp-69267	17	4	:	:	PUNCT
bjp-69267	17	5	7	7	NUM
bjp-69267	17	6	october	october	PROPN
bjp-69267	17	7	2023	2023	NUM
bjp-69267	17	8	accepted	accept	VERB
bjp-69267	17	9	:	:	PUNCT
bjp-69267	17	10	2	2	NUM
bjp-69267	17	11	december	december	PROPN
bjp-69267	17	12	2023	2023	NUM
bjp-69267	17	13	available	available	ADJ
bjp-69267	17	14	online	online	NOUN
bjp-69267	17	15	:	:	PUNCT
bjp-69267	17	16	17	17	NUM
bjp-69267	17	17	december	december	PROPN
bjp-69267	17	18	2023	2023	NUM
bjp-69267	17	19	doi	doi	NOUN
bjp-69267	17	20	:	:	PUNCT
bjp-69267	17	21	10.3329	10.3329	NUM
bjp-69267	17	22	/	/	SYM
bjp-69267	17	23	bjp.v18i4.69267	bjp.v18i4.69267	PROPN
bjp-69267	17	24	cite	cite	VERB
bjp-69267	17	25	this	this	DET
bjp-69267	17	26	article	article	NOUN
bjp-69267	17	27	:	:	PUNCT
bjp-69267	17	28	boudou	boudou	NOUN
bjp-69267	17	29	f	f	PROPN
bjp-69267	17	30	,	,	PUNCT
bjp-69267	17	31	sehmi	sehmi	PROPN
bjp-69267	17	32	a	a	PRON
bjp-69267	17	33	,	,	PUNCT
bjp-69267	17	34	belakredar	belakredar	NOUN
bjp-69267	17	35	a	a	NOUN
bjp-69267	17	36	,	,	PUNCT
bjp-69267	17	37	zaoui	zaoui	PROPN
bjp-69267	17	38	o.	o.	PROPN
bjp-69267	17	39	synthesis	synthesis	NOUN
bjp-69267	17	40	,	,	PUNCT
bjp-69267	17	41	characterization	characterization	NOUN
bjp-69267	17	42	,	,	PUNCT
bjp-69267	17	43	antimicrobial	antimicrobial	ADJ
bjp-69267	17	44	activity	activity	NOUN
bjp-69267	17	45	,	,	PUNCT
bjp-69267	17	46	and	and	CCONJ
bjp-69267	17	47	in	in	ADP
bjp-69267	17	48	silico	silico	NOUN
bjp-69267	17	49	assessment	assessment	NOUN
bjp-69267	17	50	of	of	ADP
bjp-69267	17	51	a	a	DET
bjp-69267	17	52	novel	novel	ADJ
bjp-69267	17	53	pyrazoline	pyrazoline	NOUN
bjp-69267	17	54	carboxamide	carboxamide	NOUN
bjp-69267	17	55	heterocyclic	heterocyclic	ADJ
bjp-69267	17	56	compound	compound	PROPN
bjp-69267	17	57	.	.	PUNCT
bjp-69267	18	1	bangladesh	bangladesh	PROPN
bjp-69267	18	2	j	j	PROPN
bjp-69267	18	3	pharmacol	pharmacol	PROPN
bjp-69267	18	4	.	.	PUNCT
bjp-69267	19	1	2023	2023	NUM
bjp-69267	19	2	;	;	PUNCT
bjp-69267	19	3	18	18	NUM
bjp-69267	19	4	:	:	SYM
bjp-69267	19	5	152	152	NUM
bjp-69267	19	6	-61	-61	NUM
bjp-69267	19	7	.	.	PUNCT
bjp-69267	20	1	synthesis	synthesis	NOUN
bjp-69267	20	2	,	,	PUNCT
bjp-69267	20	3	characterization	characterization	NOUN
bjp-69267	20	4	,	,	PUNCT
bjp-69267	20	5	antimicrobial	antimicrobial	ADJ
bjp-69267	20	6	activity	activity	NOUN
bjp-69267	20	7	,	,	PUNCT
bjp-69267	20	8	and	and	CCONJ
bjp-69267	20	9	in	in	ADP
bjp-69267	20	10	silico	silico	NOUN
bjp-69267	20	11	assessment	assessment	NOUN
bjp-69267	20	12	of	of	ADP
bjp-69267	20	13	a	a	DET
bjp-69267	20	14	novel	novel	ADJ
bjp-69267	20	15	pyrazoline	pyrazoline	NOUN
bjp-69267	20	16	carboxamide	carboxamide	NOUN
bjp-69267	20	17	heterocyclic	heterocyclic	PROPN
bjp-69267	20	18	compound	compound	PROPN
bjp-69267	20	19	farouk	farouk	PROPN
bjp-69267	20	20	boudou1	boudou1	PROPN
bjp-69267	20	21	,	,	PUNCT
bjp-69267	20	22	abdelghani	abdelghani	PROPN
bjp-69267	20	23	sehmi2	sehmi2	PROPN
bjp-69267	20	24	,	,	PUNCT
bjp-69267	20	25	amal	amal	PROPN
bjp-69267	20	26	belakredar1	belakredar1	PROPN
bjp-69267	20	27	and	and	CCONJ
bjp-69267	20	28	oussama	oussama	PROPN
bjp-69267	20	29	zaoui3	zaoui3	PROPN
bjp-69267	21	1	1department	1department	NUM
bjp-69267	21	2	of	of	ADP
bjp-69267	21	3	biology	biology	NOUN
bjp-69267	21	4	,	,	PUNCT
bjp-69267	21	5	faculty	faculty	NOUN
bjp-69267	21	6	of	of	ADP
bjp-69267	21	7	natural	natural	ADJ
bjp-69267	21	8	and	and	CCONJ
bjp-69267	21	9	life	life	NOUN
bjp-69267	21	10	sciences	science	NOUN
bjp-69267	21	11	,	,	PUNCT
bjp-69267	21	12	djillali	djillali	ADJ
bjp-69267	21	13	liabes	liabes	PROPN
bjp-69267	21	14	university	university	PROPN
bjp-69267	21	15	of	of	ADP
bjp-69267	21	16	sidi	sidi	PROPN
bjp-69267	21	17	-	-	PUNCT
bjp-69267	21	18	bel	bel	NOUN
bjp-69267	21	19	-	-	PUNCT
bjp-69267	21	20	abbes	abbe	NOUN
bjp-69267	21	21	,	,	PUNCT
bjp-69267	21	22	sidi	sidi	NOUN
bjp-69267	21	23	-	-	PUNCT
bjp-69267	21	24	belabbes	belabbe	NOUN
bjp-69267	21	25	22000	22000	NUM
bjp-69267	21	26	,	,	PUNCT
bjp-69267	21	27	algeria	algeria	PROPN
bjp-69267	21	28	;	;	PUNCT
bjp-69267	21	29	2department	2department	NUM
bjp-69267	21	30	of	of	ADP
bjp-69267	21	31	natural	natural	ADJ
bjp-69267	21	32	and	and	CCONJ
bjp-69267	21	33	life	life	NOUN
bjp-69267	21	34	sciences	science	NOUN
bjp-69267	21	35	,	,	PUNCT
bjp-69267	21	36	faculty	faculty	NOUN
bjp-69267	21	37	of	of	ADP
bjp-69267	21	38	sciences	science	NOUN
bjp-69267	21	39	and	and	CCONJ
bjp-69267	21	40	technology	technology	NOUN
bjp-69267	21	41	,	,	PUNCT
bjp-69267	21	42	university	university	NOUN
bjp-69267	21	43	of	of	ADP
bjp-69267	21	44	tissemsilt	tissemsilt	ADJ
bjp-69267	21	45	,	,	PUNCT
bjp-69267	21	46	tissemsilt	tissemsilt	ADJ
bjp-69267	21	47	38000	38000	NUM
bjp-69267	21	48	,	,	PUNCT
bjp-69267	21	49	algeria	algeria	PROPN
bjp-69267	21	50	;	;	PUNCT
bjp-69267	21	51	3department	3department	NUM
bjp-69267	21	52	of	of	ADP
bjp-69267	21	53	chemistry	chemistry	NOUN
bjp-69267	21	54	faculty	faculty	NOUN
bjp-69267	21	55	of	of	ADP
bjp-69267	21	56	science	science	NOUN
bjp-69267	21	57	,	,	PUNCT
bjp-69267	21	58	kasdi	kasdi	NOUN
bjp-69267	21	59	merbah	merbah	PROPN
bjp-69267	21	60	university	university	PROPN
bjp-69267	21	61	,	,	PUNCT
bjp-69267	21	62	bp	bp	PROPN
bjp-69267	21	63	511	511	NUM
bjp-69267	21	64	,	,	PUNCT
bjp-69267	21	65	ouargla	ouargla	PROPN
bjp-69267	21	66	30000	30000	NUM
bjp-69267	21	67	,	,	PUNCT
bjp-69267	21	68	algeria	algeria	PROPN
bjp-69267	21	69	.	.	PUNCT
bjp-69267	22	1	this	this	DET
bjp-69267	22	2	work	work	NOUN
bjp-69267	22	3	is	be	AUX
bjp-69267	22	4	licensed	license	VERB
bjp-69267	22	5	under	under	ADP
bjp-69267	22	6	a	a	DET
bjp-69267	22	7	creative	creative	ADJ
bjp-69267	22	8	commons	common	NOUN
bjp-69267	22	9	attribution	attribution	NOUN
bjp-69267	22	10	4.0	4.0	NUM
bjp-69267	22	11	license	license	NOUN
bjp-69267	22	12	.	.	PUNCT
bjp-69267	23	1	you	you	PRON
bjp-69267	23	2	are	be	AUX
bjp-69267	23	3	free	free	ADJ
bjp-69267	23	4	to	to	PART
bjp-69267	23	5	copy	copy	VERB
bjp-69267	23	6	,	,	PUNCT
bjp-69267	23	7	distribute	distribute	VERB
bjp-69267	23	8	and	and	CCONJ
bjp-69267	23	9	perform	perform	VERB
bjp-69267	23	10	the	the	DET
bjp-69267	23	11	work	work	NOUN
bjp-69267	23	12	.	.	PUNCT
bjp-69267	24	1	you	you	PRON
bjp-69267	24	2	must	must	AUX
bjp-69267	24	3	attribute	attribute	VERB
bjp-69267	24	4	the	the	DET
bjp-69267	24	5	work	work	NOUN
bjp-69267	24	6	in	in	ADP
bjp-69267	24	7	the	the	DET
bjp-69267	24	8	manner	manner	NOUN
bjp-69267	24	9	specified	specify	VERB
bjp-69267	24	10	by	by	ADP
bjp-69267	24	11	the	the	DET
bjp-69267	24	12	author	author	NOUN
bjp-69267	24	13	or	or	CCONJ
bjp-69267	24	14	licensor	licensor	NOUN
bjp-69267	24	15	.	.	PUNCT
bjp-69267	25	1	a	a	DET
bjp-69267	25	2	journal	journal	NOUN
bjp-69267	25	3	of	of	ADP
bjp-69267	25	4	the	the	DET
bjp-69267	25	5	bangladesh	bangladesh	NOUN
bjp-69267	25	6	pharmacological	pharmacological	ADJ
bjp-69267	25	7	society	society	NOUN
bjp-69267	25	8	(	(	PUNCT
bjp-69267	25	9	bdps	bdps	NOUN
bjp-69267	25	10	)	)	PUNCT
bjp-69267	25	11	bangladesh	bangladesh	PROPN
bjp-69267	25	12	j	j	PROPN
bjp-69267	25	13	pharmacol	pharmacol	PROPN
bjp-69267	25	14	2023	2023	NUM
bjp-69267	25	15	;	;	PUNCT
bjp-69267	25	16	18	18	NUM
bjp-69267	25	17	:	:	SYM
bjp-69267	25	18	152	152	NUM
bjp-69267	25	19	-	-	SYM
bjp-69267	25	20	161	161	NUM
bjp-69267	25	21	journal	journal	NOUN
bjp-69267	25	22	homepage	homepage	NOUN
bjp-69267	25	23	:	:	PUNCT
bjp-69267	25	24	www.bdpsjournal.org	www.bdpsjournal.org	NUM
bjp-69267	25	25	;	;	PUNCT
bjp-69267	25	26	www.banglajol.info	www.banglajol.info	PROPN
bjp-69267	25	27	abstracted	abstract	VERB
bjp-69267	25	28	/	/	SYM
bjp-69267	25	29	indexed	index	VERB
bjp-69267	25	30	in	in	ADP
bjp-69267	25	31	academic	academic	ADJ
bjp-69267	25	32	search	search	NOUN
bjp-69267	25	33	complete	complete	ADJ
bjp-69267	25	34	,	,	PUNCT
bjp-69267	25	35	agroforestry	agroforestry	NOUN
bjp-69267	25	36	abstracts	abstract	NOUN
bjp-69267	25	37	,	,	PUNCT
bjp-69267	25	38	asia	asia	PROPN
bjp-69267	25	39	journals	journal	NOUN
bjp-69267	25	40	online	online	ADV
bjp-69267	25	41	,	,	PUNCT
bjp-69267	25	42	bangladesh	bangladesh	NOUN
bjp-69267	25	43	journals	journal	NOUN
bjp-69267	25	44	online	online	ADV
bjp-69267	25	45	,	,	PUNCT
bjp-69267	25	46	biological	biological	ADJ
bjp-69267	25	47	abstracts	abstract	NOUN
bjp-69267	25	48	,	,	PUNCT
bjp-69267	25	49	biosis	biosis	NOUN
bjp-69267	25	50	previews	preview	NOUN
bjp-69267	25	51	,	,	PUNCT
bjp-69267	25	52	cab	cab	NOUN
bjp-69267	25	53	abstracts	abstract	NOUN
bjp-69267	25	54	,	,	PUNCT
bjp-69267	25	55	current	current	ADJ
bjp-69267	25	56	abstracts	abstract	NOUN
bjp-69267	25	57	,	,	PUNCT
bjp-69267	25	58	directory	directory	NOUN
bjp-69267	25	59	of	of	ADP
bjp-69267	25	60	open	open	ADJ
bjp-69267	25	61	access	access	NOUN
bjp-69267	25	62	journals	journal	NOUN
bjp-69267	25	63	,	,	PUNCT
bjp-69267	25	64	embase	embase	NOUN
bjp-69267	25	65	/	/	SYM
bjp-69267	25	66	excerpta	excerpta	NOUN
bjp-69267	25	67	medica	medica	NOUN
bjp-69267	25	68	,	,	PUNCT
bjp-69267	25	69	global	global	ADJ
bjp-69267	25	70	health	health	NOUN
bjp-69267	25	71	,	,	PUNCT
bjp-69267	25	72	google	google	PROPN
bjp-69267	25	73	scholar	scholar	NOUN
bjp-69267	25	74	,	,	PUNCT
bjp-69267	25	75	hinari	hinari	X
bjp-69267	25	76	(	(	PUNCT
bjp-69267	25	77	who	who	PRON
bjp-69267	25	78	)	)	PUNCT
bjp-69267	25	79	,	,	PUNCT
bjp-69267	25	80	international	international	ADJ
bjp-69267	25	81	pharmaceutical	pharmaceutical	ADJ
bjp-69267	25	82	abstracts	abstract	NOUN
bjp-69267	25	83	,	,	PUNCT
bjp-69267	25	84	open	open	ADJ
bjp-69267	25	85	j	j	PROPN
bjp-69267	25	86	-	-	PUNCT
bjp-69267	25	87	gate	gate	NOUN
bjp-69267	25	88	,	,	PUNCT
bjp-69267	25	89	science	science	NOUN
bjp-69267	25	90	citation	citation	NOUN
bjp-69267	25	91	index	index	NOUN
bjp-69267	25	92	expanded	expand	VERB
bjp-69267	25	93	,	,	PUNCT
bjp-69267	25	94	scopus	scopus	NOUN
bjp-69267	25	95	and	and	CCONJ
bjp-69267	25	96	social	social	ADJ
bjp-69267	25	97	sciences	sciences	PROPN
bjp-69267	25	98	citation	citation	NOUN
bjp-69267	25	99	index	index	NOUN
bjp-69267	25	100	issn	issn	PROPN
bjp-69267	25	101	:	:	PUNCT
bjp-69267	25	102	1991	1991	NUM
bjp-69267	25	103	-	-	SYM
bjp-69267	25	104	0088	0088	NUM
bjp-69267	25	105	subject	subject	NOUN
bjp-69267	25	106	of	of	ADP
bjp-69267	25	107	great	great	ADJ
bjp-69267	25	108	interest	interest	NOUN
bjp-69267	25	109	and	and	CCONJ
bjp-69267	25	110	exploration	exploration	NOUN
bjp-69267	25	111	(	(	PUNCT
bjp-69267	25	112	ebenezer	ebenezer	PROPN
bjp-69267	25	113	et	et	PROPN
bjp-69267	25	114	al	al	PROPN
bjp-69267	25	115	.	.	PROPN
bjp-69267	25	116	,	,	PUNCT
bjp-69267	25	117	2022	2022	NUM
bjp-69267	25	118	)	)	PUNCT
bjp-69267	25	119	.	.	PUNCT
bjp-69267	26	1	the	the	DET
bjp-69267	26	2	addition	addition	NOUN
bjp-69267	26	3	of	of	ADP
bjp-69267	26	4	the	the	DET
bjp-69267	26	5	5-(4-(dimethylamino)phenyl)3	5-(4-(dimethylamino)phenyl)3	NUM
bjp-69267	26	6	-	-	PUNCT
bjp-69267	26	7	phenyl-4,5	phenyl-4,5	VERB
bjp-69267	26	8	-	-	PUNCT
bjp-69267	26	9	dihydro-1h	dihydro-1h	NOUN
bjp-69267	26	10	-	-	PUNCT
bjp-69267	26	11	pyrazole-1	pyrazole-1	NOUN
bjp-69267	26	12	-	-	PUNCT
bjp-69267	26	13	carboxamide	carboxamide	NOUN
bjp-69267	26	14	moiety	moiety	NOUN
bjp-69267	26	15	has	have	AUX
bjp-69267	26	16	significantly	significantly	ADV
bjp-69267	26	17	enhanced	enhance	VERB
bjp-69267	26	18	the	the	DET
bjp-69267	26	19	structural	structural	ADJ
bjp-69267	26	20	diversity	diversity	NOUN
bjp-69267	26	21	and	and	CCONJ
bjp-69267	26	22	biological	biological	ADJ
bjp-69267	26	23	potential	potential	NOUN
bjp-69267	26	24	of	of	ADP
bjp-69267	26	25	pyrazolines	pyrazoline	NOUN
bjp-69267	26	26	,	,	PUNCT
bjp-69267	26	27	opening	open	VERB
bjp-69267	26	28	up	up	ADP
bjp-69267	26	29	interesting	interesting	ADJ
bjp-69267	26	30	therapeutic	therapeutic	ADJ
bjp-69267	26	31	prospect	prospect	NOUN
bjp-69267	26	32	(	(	PUNCT
bjp-69267	26	33	ebenezer	ebenezer	PROPN
bjp-69267	26	34	et	et	PROPN
bjp-69267	26	35	al	al	PROPN
bjp-69267	26	36	.	.	PROPN
bjp-69267	26	37	,	,	PUNCT
bjp-69267	26	38	2022	2022	NUM
bjp-69267	26	39	)	)	PUNCT
bjp-69267	26	40	.	.	PUNCT
bjp-69267	27	1	the	the	DET
bjp-69267	27	2	present	present	ADJ
bjp-69267	27	3	researches	research	VERB
bjp-69267	27	4	highlighted	highlight	VERB
bjp-69267	27	5	the	the	DET
bjp-69267	27	6	synthesis	synthesis	NOUN
bjp-69267	27	7	,	,	PUNCT
bjp-69267	27	8	spectroscopic	spectroscopic	ADJ
bjp-69267	27	9	characterization	characterization	NOUN
bjp-69267	27	10	and	and	CCONJ
bjp-69267	27	11	antimicrobial	antimicrobial	ADJ
bjp-69267	27	12	activity	activity	NOUN
bjp-69267	27	13	of	of	ADP
bjp-69267	27	14	novel	novel	ADJ
bjp-69267	27	15	pyrazoline	pyrazoline	NOUN
bjp-69267	27	16	derivative	derivative	ADJ
bjp-69267	27	17	5-(4-(dimethylamino)phenyl)-3	5-(4-(dimethylamino)phenyl)-3	NUM
bjp-69267	27	18	-	-	PUNCT
bjp-69267	27	19	phenyl-4,5	phenyl-4,5	VERB
bjp-69267	27	20	-	-	PUNCT
bjp-69267	27	21	dihydro-1h	dihydro-1h	NOUN
bjp-69267	27	22	-	-	PUNCT
bjp-69267	27	23	pyrazole-1	pyrazole-1	NOUN
bjp-69267	27	24	-	-	PUNCT
bjp-69267	27	25	carboxamide	carboxamide	NOUN
bjp-69267	27	26	(	(	PUNCT
bjp-69267	27	27	pyr	pyr	NOUN
bjp-69267	27	28	)	)	PUNCT
bjp-69267	27	29	.	.	PUNCT
bjp-69267	28	1	in	in	ADP
bjp-69267	28	2	the	the	DET
bjp-69267	28	3	last	last	ADJ
bjp-69267	28	4	phase	phase	NOUN
bjp-69267	28	5	of	of	ADP
bjp-69267	28	6	this	this	DET
bjp-69267	28	7	study	study	NOUN
bjp-69267	28	8	,	,	PUNCT
bjp-69267	28	9	an	an	DET
bjp-69267	28	10	in	in	ADP
bjp-69267	28	11	-	-	PUNCT
bjp-69267	28	12	depth	depth	NOUN
bjp-69267	28	13	in	in	ADP
bjp-69267	28	14	silico	silico	NOUN
bjp-69267	28	15	analysis	analysis	NOUN
bjp-69267	28	16	was	be	AUX
bjp-69267	28	17	conducted	conduct	VERB
bjp-69267	28	18	to	to	PART
bjp-69267	28	19	elucidate	elucidate	VERB
bjp-69267	28	20	the	the	DET
bjp-69267	28	21	potential	potential	ADJ
bjp-69267	28	22	antimicrobial	antimicrobial	ADJ
bjp-69267	28	23	mechanisms	mechanism	NOUN
bjp-69267	28	24	of	of	ADP
bjp-69267	28	25	the	the	DET
bjp-69267	28	26	novel	novel	ADJ
bjp-69267	28	27	heterocyclic	heterocyclic	ADJ
bjp-69267	28	28	compound	compound	NOUN
bjp-69267	28	29	pyrazoline	pyrazoline	NOUN
bjp-69267	28	30	carboxamide	carboxamide	NOUN
bjp-69267	28	31	.	.	PUNCT
bjp-69267	29	1	materials	material	NOUN
bjp-69267	29	2	and	and	CCONJ
bjp-69267	29	3	methods	method	NOUN
bjp-69267	29	4	chemicals	chemical	NOUN
bjp-69267	29	5	and	and	CCONJ
bjp-69267	29	6	reagents	reagent	NOUN
bjp-69267	29	7	the	the	DET
bjp-69267	29	8	starting	start	VERB
bjp-69267	29	9	materials	material	NOUN
bjp-69267	29	10	,	,	PUNCT
bjp-69267	29	11	reagents	reagent	NOUN
bjp-69267	29	12	,	,	PUNCT
bjp-69267	29	13	solvents	solvent	NOUN
bjp-69267	29	14	,	,	PUNCT
bjp-69267	29	15	and	and	CCONJ
bjp-69267	29	16	microbiological	microbiological	ADJ
bjp-69267	29	17	culture	culture	NOUN
bjp-69267	29	18	media	medium	NOUN
bjp-69267	29	19	were	be	AUX
bjp-69267	29	20	purchased	purchase	VERB
bjp-69267	29	21	from	from	ADP
bjp-69267	29	22	sigmaaldrich	sigmaaldrich	PROPN
bjp-69267	29	23	(	(	PUNCT
bjp-69267	29	24	usa	usa	PROPN
bjp-69267	29	25	)	)	PUNCT
bjp-69267	29	26	and	and	CCONJ
bjp-69267	29	27	merck	merck	PROPN
bjp-69267	29	28	(	(	PUNCT
bjp-69267	29	29	germany	germany	PROPN
bjp-69267	29	30	)	)	PUNCT
bjp-69267	29	31	and	and	CCONJ
bjp-69267	29	32	used	use	VERB
bjp-69267	29	33	without	without	ADP
bjp-69267	29	34	additional	additional	ADJ
bjp-69267	29	35	purification	purification	NOUN
bjp-69267	29	36	.	.	PUNCT
bjp-69267	30	1	thin	thin	ADJ
bjp-69267	30	2	-	-	PUNCT
bjp-69267	30	3	layer	layer	NOUN
bjp-69267	30	4	chromatography	chromatography	NOUN
bjp-69267	30	5	analytical	analytical	ADJ
bjp-69267	30	6	thin	thin	ADJ
bjp-69267	30	7	-	-	PUNCT
bjp-69267	30	8	layer	layer	NOUN
bjp-69267	30	9	chromatography	chromatography	NOUN
bjp-69267	30	10	(	(	PUNCT
bjp-69267	30	11	tlc	tlc	NOUN
bjp-69267	30	12	)	)	PUNCT
bjp-69267	30	13	was	be	AUX
bjp-69267	30	14	conducted	conduct	VERB
bjp-69267	30	15	using	use	VERB
bjp-69267	30	16	pre	pre	ADJ
bjp-69267	30	17	-	-	ADJ
bjp-69267	30	18	coated	coated	ADJ
bjp-69267	30	19	silica	silica	NOUN
bjp-69267	30	20	gel	gel	NOUN
bjp-69267	30	21	plates	plate	NOUN
bjp-69267	30	22	(	(	PUNCT
bjp-69267	30	23	60	60	NUM
bjp-69267	30	24	f254	f254	PROPN
bjp-69267	30	25	,	,	PUNCT
bjp-69267	30	26	merck	merck	PROPN
bjp-69267	30	27	)	)	PUNCT
bjp-69267	30	28	with	with	ADP
bjp-69267	30	29	cyclohexane	cyclohexane	NOUN
bjp-69267	30	30	:	:	PUNCT
bjp-69267	30	31	ethyl	ethyl	PROPN
bjp-69267	30	32	acetate	acetate	NOUN
bjp-69267	30	33	(	(	PUNCT
bjp-69267	30	34	9.5:0.5	9.5:0.5	NUM
bjp-69267	30	35	,	,	PUNCT
bjp-69267	30	36	v	v	NOUN
bjp-69267	30	37	/	/	SYM
bjp-69267	30	38	v	v	NOUN
bjp-69267	30	39	)	)	PUNCT
bjp-69267	30	40	as	as	ADP
bjp-69267	30	41	the	the	DET
bjp-69267	30	42	mobile	mobile	ADJ
bjp-69267	30	43	phase	phase	NOUN
bjp-69267	30	44	.	.	PUNCT
bjp-69267	31	1	following	follow	VERB
bjp-69267	31	2	development	development	NOUN
bjp-69267	31	3	,	,	PUNCT
bjp-69267	31	4	the	the	DET
bjp-69267	31	5	plate	plate	NOUN
bjp-69267	31	6	was	be	AUX
bjp-69267	31	7	air	air	NOUN
bjp-69267	31	8	-	-	PUNCT
bjp-69267	31	9	dried	dry	VERB
bjp-69267	31	10	,	,	PUNCT
bjp-69267	31	11	and	and	CCONJ
bjp-69267	31	12	the	the	DET
bjp-69267	31	13	separated	separate	VERB
bjp-69267	31	14	components	component	NOUN
bjp-69267	31	15	were	be	AUX
bjp-69267	31	16	visualized	visualize	VERB
bjp-69267	31	17	using	use	VERB
bjp-69267	31	18	iodine	iodine	NOUN
bjp-69267	31	19	(	(	PUNCT
bjp-69267	31	20	i2	i2	PROPN
bjp-69267	31	21	)	)	PUNCT
bjp-69267	31	22	for	for	ADP
bjp-69267	31	23	enhanced	enhanced	ADJ
bjp-69267	31	24	detection	detection	NOUN
bjp-69267	31	25	(	(	PUNCT
bjp-69267	31	26	venkataraman	venkataraman	NOUN
bjp-69267	31	27	et	et	PROPN
bjp-69267	31	28	al	al	PROPN
bjp-69267	31	29	.	.	PROPN
bjp-69267	31	30	,	,	PUNCT
bjp-69267	31	31	2010	2010	NUM
bjp-69267	31	32	)	)	PUNCT
bjp-69267	31	33	.	.	PUNCT
bjp-69267	32	1	synthesis	synthesis	NOUN
bjp-69267	32	2	of	of	ADP
bjp-69267	32	3	5-(4-(dimethylamino)phenyl)-3	5-(4-(dimethylamino)phenyl)-3	PROPN
bjp-69267	32	4	-	-	PUNCT
bjp-69267	32	5	phenyl-4,5	phenyl-4,5	NOUN
bjp-69267	32	6	-dihydro-1h	-dihydro-1h	NUM
bjp-69267	32	7	-	-	PUNCT
bjp-69267	32	8	pyrazole-1	pyrazole-1	NOUN
bjp-69267	32	9	-	-	NOUN
bjp-69267	32	10	carboxamide	carboxamide	NOUN
bjp-69267	32	11	in	in	ADP
bjp-69267	32	12	the	the	DET
bjp-69267	32	13	initial	initial	ADJ
bjp-69267	32	14	step	step	NOUN
bjp-69267	32	15	,	,	PUNCT
bjp-69267	32	16	the	the	DET
bjp-69267	32	17	intermediate	intermediate	ADJ
bjp-69267	32	18	α	α	NOUN
bjp-69267	32	19	,	,	PUNCT
bjp-69267	32	20	β	β	ADJ
bjp-69267	32	21	-	-	ADJ
bjp-69267	32	22	unsaturated	unsaturated	ADJ
bjp-69267	32	23	ketone	ketone	NOUN
bjp-69267	32	24	(	(	PUNCT
bjp-69267	32	25	chalcone	chalcone	NOUN
bjp-69267	32	26	derivative	derivative	NOUN
bjp-69267	32	27	)	)	PUNCT
bjp-69267	32	28	was	be	AUX
bjp-69267	32	29	synthesized	synthesize	VERB
bjp-69267	32	30	according	accord	VERB
bjp-69267	32	31	to	to	ADP
bjp-69267	32	32	the	the	DET
bjp-69267	32	33	reported	report	VERB
bjp-69267	32	34	procedure	procedure	NOUN
bjp-69267	32	35	(	(	PUNCT
bjp-69267	32	36	sehmi	sehmi	PROPN
bjp-69267	32	37	et	et	PROPN
bjp-69267	32	38	al	al	PROPN
bjp-69267	32	39	.	.	PROPN
bjp-69267	32	40	,	,	PUNCT
bjp-69267	32	41	2020	2020	NUM
bjp-69267	32	42	)	)	PUNCT
bjp-69267	32	43	.	.	PUNCT
bjp-69267	33	1	an	an	DET
bjp-69267	33	2	aqueous	aqueous	ADJ
bjp-69267	33	3	solution	solution	NOUN
bjp-69267	33	4	of	of	ADP
bjp-69267	33	5	sodium	sodium	NOUN
bjp-69267	33	6	hydroxide	hydroxide	NOUN
bjp-69267	33	7	(	(	PUNCT
bjp-69267	33	8	1.3	1.3	NUM
bjp-69267	33	9	g	g	NOUN
bjp-69267	33	10	,	,	PUNCT
bjp-69267	33	11	0.032	0.032	NUM
bjp-69267	33	12	mol	mol	NOUN
bjp-69267	33	13	)	)	PUNCT
bjp-69267	33	14	was	be	AUX
bjp-69267	33	15	added	add	VERB
bjp-69267	33	16	dropwise	dropwise	NOUN
bjp-69267	33	17	to	to	ADP
bjp-69267	33	18	a	a	DET
bjp-69267	33	19	stirred	stir	VERB
bjp-69267	33	20	solution	solution	NOUN
bjp-69267	33	21	of	of	ADP
bjp-69267	33	22	4-(dimethyl	4-(dimethyl	NUM
bjp-69267	33	23	-amino)benzaldehyde	-amino)benzaldehyde	PUNCT
bjp-69267	33	24	(	(	PUNCT
bjp-69267	33	25	2.5	2.5	NUM
bjp-69267	33	26	g	g	NOUN
bjp-69267	33	27	,	,	PUNCT
bjp-69267	33	28	0.016	0.016	NUM
bjp-69267	33	29	mol	mol	NOUN
bjp-69267	33	30	)	)	PUNCT
bjp-69267	33	31	and	and	CCONJ
bjp-69267	33	32	acetophenone	acetophenone	NOUN
bjp-69267	33	33	(	(	PUNCT
bjp-69267	33	34	2.0	2.0	NUM
bjp-69267	33	35	g	g	NOUN
bjp-69267	33	36	,	,	PUNCT
bjp-69267	33	37	0.016	0.016	NUM
bjp-69267	33	38	mol	mol	NOUN
bjp-69267	33	39	)	)	PUNCT
bjp-69267	33	40	in	in	ADP
bjp-69267	33	41	ethanol	ethanol	NOUN
bjp-69267	33	42	.	.	PUNCT
bjp-69267	34	1	the	the	DET
bjp-69267	34	2	reaction	reaction	NOUN
bjp-69267	34	3	mixture	mixture	NOUN
bjp-69267	34	4	was	be	AUX
bjp-69267	34	5	stirred	stir	VERB
bjp-69267	34	6	at	at	ADP
bjp-69267	34	7	room	room	NOUN
bjp-69267	34	8	temperature	temperature	NOUN
bjp-69267	34	9	overnight	overnight	ADV
bjp-69267	34	10	.	.	PUNCT
bjp-69267	35	1	the	the	DET
bjp-69267	35	2	precipitate	precipitate	NOUN
bjp-69267	35	3	was	be	AUX
bjp-69267	35	4	filtered	filter	VERB
bjp-69267	35	5	,	,	PUNCT
bjp-69267	35	6	and	and	CCONJ
bjp-69267	35	7	washed	wash	VERB
bjp-69267	35	8	with	with	ADP
bjp-69267	35	9	cold	cold	ADJ
bjp-69267	35	10	water	water	NOUN
bjp-69267	35	11	until	until	SCONJ
bjp-69267	35	12	neutral	neutral	ADJ
bjp-69267	35	13	ph	ph	NOUN
bjp-69267	35	14	was	be	AUX
bjp-69267	35	15	obtained	obtain	VERB
bjp-69267	35	16	,	,	PUNCT
bjp-69267	35	17	the	the	DET
bjp-69267	35	18	crude	crude	ADJ
bjp-69267	35	19	solid	solid	NOUN
bjp-69267	35	20	was	be	AUX
bjp-69267	35	21	dried	dry	VERB
bjp-69267	35	22	and	and	CCONJ
bjp-69267	35	23	then	then	ADV
bjp-69267	35	24	recrystallized	recrystallize	VERB
bjp-69267	35	25	in	in	ADP
bjp-69267	35	26	ethanol	ethanol	NOUN
bjp-69267	35	27	.	.	PUNCT
bjp-69267	36	1	the	the	DET
bjp-69267	36	2	subsequent	subsequent	ADJ
bjp-69267	36	3	step	step	NOUN
bjp-69267	36	4	involved	involve	VERB
bjp-69267	36	5	the	the	DET
bjp-69267	36	6	synthesis	synthesis	NOUN
bjp-69267	36	7	of	of	ADP
bjp-69267	36	8	pyrazoline	pyrazoline	NOUN
bjp-69267	36	9	carboxamide	carboxamide	NOUN
bjp-69267	36	10	derivative	derivative	NOUN
bjp-69267	36	11	.	.	PUNCT
bjp-69267	37	1	to	to	ADP
bjp-69267	37	2	a	a	DET
bjp-69267	37	3	stirred	stir	VERB
bjp-69267	37	4	ethanolic	ethanolic	ADJ
bjp-69267	37	5	solution	solution	NOUN
bjp-69267	37	6	of	of	ADP
bjp-69267	37	7	chalcone	chalcone	NOUN
bjp-69267	37	8	derivative	derivative	NOUN
bjp-69267	37	9	(	(	PUNCT
bjp-69267	37	10	2	2	NUM
bjp-69267	37	11	g	g	NOUN
bjp-69267	37	12	,	,	PUNCT
bjp-69267	37	13	0.008	0.008	NUM
bjp-69267	37	14	mol	mol	NOUN
bjp-69267	37	15	)	)	PUNCT
bjp-69267	37	16	and	and	CCONJ
bjp-69267	37	17	semicarbazide	semicarbazide	NOUN
bjp-69267	37	18	hydrochloride	hydrochloride	NOUN
bjp-69267	37	19	,	,	PUNCT
bjp-69267	37	20	(	(	PUNCT
bjp-69267	37	21	0.97	0.97	NUM
bjp-69267	37	22	g	g	NOUN
bjp-69267	37	23	,	,	PUNCT
bjp-69267	37	24	0.008	0.008	NUM
bjp-69267	37	25	mol	mol	NOUN
bjp-69267	37	26	)	)	PUNCT
bjp-69267	37	27	,	,	PUNCT
bjp-69267	37	28	sodium	sodium	NOUN
bjp-69267	37	29	hydroxide	hydroxide	NOUN
bjp-69267	37	30	(	(	PUNCT
bjp-69267	37	31	0.7	0.7	NUM
bjp-69267	37	32	g	g	NOUN
bjp-69267	37	33	,	,	PUNCT
bjp-69267	37	34	0.017	0.017	NUM
bjp-69267	37	35	mol	mol	NOUN
bjp-69267	37	36	)	)	PUNCT
bjp-69267	37	37	in	in	ADP
bjp-69267	37	38	ethanol	ethanol	NOUN
bjp-69267	37	39	was	be	AUX
bjp-69267	37	40	added	add	VERB
bjp-69267	37	41	dropwise	dropwise	NOUN
bjp-69267	37	42	.	.	PUNCT
bjp-69267	38	1	the	the	DET
bjp-69267	38	2	reaction	reaction	NOUN
bjp-69267	38	3	mixture	mixture	NOUN
bjp-69267	38	4	was	be	AUX
bjp-69267	38	5	refluxed	refluxe	VERB
bjp-69267	38	6	for	for	ADP
bjp-69267	38	7	6	6	NUM
bjp-69267	38	8	-	-	SYM
bjp-69267	38	9	7	7	NUM
bjp-69267	38	10	hours	hour	NOUN
bjp-69267	38	11	.	.	PUNCT
bjp-69267	39	1	the	the	DET
bjp-69267	39	2	reaction	reaction	NOUN
bjp-69267	39	3	progress	progress	NOUN
bjp-69267	39	4	was	be	AUX
bjp-69267	39	5	monitored	monitor	VERB
bjp-69267	39	6	for	for	ADP
bjp-69267	39	7	chalcone	chalcone	NOUN
bjp-69267	39	8	disappearance	disappearance	NOUN
bjp-69267	39	9	by	by	ADP
bjp-69267	39	10	tlc	tlc	NOUN
bjp-69267	39	11	using	use	VERB
bjp-69267	39	12	ethyl	ethyl	PROPN
bjp-69267	39	13	acetate	acetate	PROPN
bjp-69267	39	14	/	/	SYM
bjp-69267	39	15	hexane	hexane	NOUN
bjp-69267	39	16	mixture	mixture	NOUN
bjp-69267	39	17	(	(	PUNCT
bjp-69267	39	18	1:3	1:3	NUM
bjp-69267	39	19	)	)	PUNCT
bjp-69267	39	20	.	.	PUNCT
bjp-69267	40	1	after	after	ADP
bjp-69267	40	2	completion	completion	NOUN
bjp-69267	40	3	,	,	PUNCT
bjp-69267	40	4	the	the	DET
bjp-69267	40	5	reaction	reaction	NOUN
bjp-69267	40	6	mixture	mixture	NOUN
bjp-69267	40	7	was	be	AUX
bjp-69267	40	8	cooled	cool	VERB
bjp-69267	40	9	down	down	ADP
bjp-69267	40	10	and	and	CCONJ
bjp-69267	40	11	then	then	ADV
bjp-69267	40	12	poured	pour	VERB
bjp-69267	40	13	on	on	ADP
bjp-69267	40	14	crushed	crush	VERB
bjp-69267	40	15	ice	ice	NOUN
bjp-69267	40	16	to	to	PART
bjp-69267	40	17	get	get	VERB
bjp-69267	40	18	the	the	DET
bjp-69267	40	19	yellow	yellow	ADJ
bjp-69267	40	20	precipitate	precipitate	NOUN
bjp-69267	40	21	that	that	PRON
bjp-69267	40	22	was	be	AUX
bjp-69267	40	23	later	later	ADV
bjp-69267	40	24	recrystallized	recrystallize	VERB
bjp-69267	40	25	with	with	ADP
bjp-69267	40	26	ethanol	ethanol	NOUN
bjp-69267	40	27	and	and	CCONJ
bjp-69267	40	28	chloroform	chloroform	NOUN
bjp-69267	40	29	mixture	mixture	NOUN
bjp-69267	40	30	(	(	PUNCT
bjp-69267	40	31	8:2	8:2	NUM
bjp-69267	40	32	)	)	PUNCT
bjp-69267	40	33	.	.	PUNCT
bjp-69267	41	1	characterization	characterization	NOUN
bjp-69267	41	2	methods	method	NOUN
bjp-69267	41	3	melting	melt	VERB
bjp-69267	41	4	points	point	NOUN
bjp-69267	41	5	of	of	ADP
bjp-69267	41	6	the	the	DET
bjp-69267	41	7	synthesized	synthesize	VERB
bjp-69267	41	8	compound	compound	NOUN
bjp-69267	41	9	were	be	AUX
bjp-69267	41	10	determined	determine	VERB
bjp-69267	41	11	by	by	ADP
bjp-69267	41	12	a	a	DET
bjp-69267	41	13	köfler	köfler	NOUN
bjp-69267	41	14	hot	hot	ADJ
bjp-69267	41	15	-	-	PUNCT
bjp-69267	41	16	stage	stage	NOUN
bjp-69267	41	17	apparatus	apparatus	NOUN
bjp-69267	41	18	(	(	PUNCT
bjp-69267	41	19	wagner	wagner	PROPN
bjp-69267	41	20	&	&	CCONJ
bjp-69267	41	21	munz	munz	PROPN
bjp-69267	41	22	,	,	PUNCT
bjp-69267	41	23	germany	germany	PROPN
bjp-69267	41	24	)	)	PUNCT
bjp-69267	41	25	.	.	PUNCT
bjp-69267	42	1	the	the	DET
bjp-69267	42	2	ft	ft	PROPN
bjp-69267	42	3	-	-	PUNCT
bjp-69267	42	4	ir	ir	PROPN
bjp-69267	42	5	measurements	measurement	NOUN
bjp-69267	42	6	were	be	AUX
bjp-69267	42	7	carried	carry	VERB
bjp-69267	42	8	out	out	ADP
bjp-69267	42	9	at	at	ADP
bjp-69267	42	10	room	room	NOUN
bjp-69267	42	11	temperature	temperature	NOUN
bjp-69267	42	12	using	use	VERB
bjp-69267	42	13	jasco	jasco	PROPN
bjp-69267	42	14	4000	4000	NUM
bjp-69267	42	15	made	make	VERB
bjp-69267	42	16	in	in	ADP
bjp-69267	42	17	japan	japan	PROPN
bjp-69267	42	18	.	.	PUNCT
bjp-69267	43	1	the	the	DET
bjp-69267	43	2	spectrum	spectrum	NOUN
bjp-69267	43	3	was	be	AUX
bjp-69267	43	4	collected	collect	VERB
bjp-69267	43	5	by	by	ADP
bjp-69267	43	6	the	the	DET
bjp-69267	43	7	kbr	kbr	PROPN
bjp-69267	43	8	-	-	PUNCT
bjp-69267	43	9	discs	disc	NOUN
bjp-69267	43	10	method	method	NOUN
bjp-69267	43	11	in	in	ADP
bjp-69267	43	12	the	the	DET
bjp-69267	43	13	infrared	infrared	ADJ
bjp-69267	43	14	spectral	spectral	ADJ
bjp-69267	43	15	range	range	NOUN
bjp-69267	43	16	of	of	ADP
bjp-69267	43	17	4000	4000	NUM
bjp-69267	43	18	-	-	SYM
bjp-69267	43	19	400	400	NUM
bjp-69267	43	20	cm-1	cm-1	NOUN
bjp-69267	43	21	with	with	ADP
bjp-69267	43	22	a	a	DET
bjp-69267	43	23	resolution	resolution	NOUN
bjp-69267	43	24	of	of	ADP
bjp-69267	43	25	4	4	NUM
bjp-69267	43	26	cm-1	cm-1	NOUN
bjp-69267	43	27	.	.	PUNCT
bjp-69267	44	1	bangladesh	bangladesh	PROPN
bjp-69267	44	2	j	j	PROPN
bjp-69267	44	3	pharmacol	pharmacol	PROPN
bjp-69267	44	4	2023	2023	NUM
bjp-69267	44	5	;	;	PUNCT
bjp-69267	44	6	18	18	NUM
bjp-69267	44	7	:	:	SYM
bjp-69267	44	8	152	152	NUM
bjp-69267	44	9	-	-	SYM
bjp-69267	44	10	161	161	NUM
bjp-69267	44	11	153	153	NUM
bjp-69267	44	12	box	box	NOUN
bjp-69267	44	13	1	1	NUM
bjp-69267	44	14	:	:	PUNCT
bjp-69267	44	15	antibacterial	antibacterial	ADJ
bjp-69267	44	16	and	and	CCONJ
bjp-69267	44	17	antifungal	antifungal	ADJ
bjp-69267	44	18	activity	activity	NOUN
bjp-69267	44	19	principle	principle	NOUN
bjp-69267	44	20	the	the	DET
bjp-69267	44	21	agar	agar	NOUN
bjp-69267	44	22	diffusion	diffusion	NOUN
bjp-69267	44	23	method	method	NOUN
bjp-69267	44	24	was	be	AUX
bjp-69267	44	25	employed	employ	VERB
bjp-69267	44	26	to	to	PART
bjp-69267	44	27	assess	assess	VERB
bjp-69267	44	28	both	both	CCONJ
bjp-69267	44	29	antibacterial	antibacterial	ADJ
bjp-69267	44	30	and	and	CCONJ
bjp-69267	44	31	antifungal	antifungal	ADJ
bjp-69267	44	32	activities	activity	NOUN
bjp-69267	44	33	.	.	PUNCT
bjp-69267	45	1	requirements	requirement	NOUN
bjp-69267	45	2	incubator	incubator	NOUN
bjp-69267	45	3	,	,	PUNCT
bjp-69267	45	4	mueller	mueller	PROPN
bjp-69267	45	5	-	-	PUNCT
bjp-69267	45	6	hinton	hinton	PROPN
bjp-69267	45	7	agar	agar	NOUN
bjp-69267	45	8	(	(	PUNCT
bjp-69267	45	9	2	2	NUM
bjp-69267	45	10	%	%	NOUN
bjp-69267	45	11	beef	beef	NOUN
bjp-69267	45	12	extract	extract	NOUN
bjp-69267	45	13	,	,	PUNCT
bjp-69267	45	14	17.5	17.5	NUM
bjp-69267	45	15	%	%	NOUN
bjp-69267	45	16	acid	acid	NOUN
bjp-69267	45	17	hydrolysate	hydrolysate	NOUN
bjp-69267	45	18	of	of	ADP
bjp-69267	45	19	casein	casein	NOUN
bjp-69267	45	20	,	,	PUNCT
bjp-69267	45	21	1.5	1.5	NUM
bjp-69267	45	22	%	%	NOUN
bjp-69267	45	23	starch	starch	NOUN
bjp-69267	45	24	,	,	PUNCT
bjp-69267	45	25	and	and	CCONJ
bjp-69267	45	26	1.5	1.5	NUM
bjp-69267	45	27	%	%	NOUN
bjp-69267	45	28	agar	agar	NOUN
bjp-69267	45	29	)	)	PUNCT
bjp-69267	45	30	,	,	PUNCT
bjp-69267	45	31	sabouraud	sabouraud	NOUN
bjp-69267	45	32	agar	agar	NOUN
bjp-69267	45	33	medium	medium	NOUN
bjp-69267	45	34	(	(	PUNCT
bjp-69267	45	35	1	1	NUM
bjp-69267	45	36	%	%	NOUN
bjp-69267	45	37	yeast	yeast	NOUN
bjp-69267	45	38	extract	extract	NOUN
bjp-69267	45	39	,	,	PUNCT
bjp-69267	45	40	2	2	NUM
bjp-69267	45	41	%	%	NOUN
bjp-69267	45	42	peptone	peptone	NOUN
bjp-69267	45	43	,	,	PUNCT
bjp-69267	45	44	2	2	NUM
bjp-69267	45	45	%	%	NOUN
bjp-69267	45	46	dextrose	dextrose	NOUN
bjp-69267	45	47	,	,	PUNCT
bjp-69267	45	48	and	and	CCONJ
bjp-69267	45	49	2	2	NUM
bjp-69267	45	50	%	%	NOUN
bjp-69267	45	51	agar	agar	NOUN
bjp-69267	45	52	)	)	PUNCT
bjp-69267	45	53	plate	plate	NOUN
bjp-69267	45	54	,	,	PUNCT
bjp-69267	45	55	sterile	sterile	ADJ
bjp-69267	45	56	swab	swab	NOUN
bjp-69267	45	57	,	,	PUNCT
bjp-69267	45	58	test	test	NOUN
bjp-69267	45	59	pathogens	pathogen	NOUN
bjp-69267	45	60	escherichia	escherichia	NOUN
bjp-69267	45	61	coli	coli	NOUN
bjp-69267	45	62	atcc	atcc	NOUN
bjp-69267	45	63	25922	25922	NUM
bjp-69267	45	64	,	,	PUNCT
bjp-69267	45	65	staphylococcus	staphylococcus	NOUN
bjp-69267	45	66	aureus	aureus	PROPN
bjp-69267	45	67	atcc	atcc	PROPN
bjp-69267	45	68	25923	25923	NUM
bjp-69267	45	69	,	,	PUNCT
bjp-69267	45	70	pseudomonas	pseudomona	VERB
bjp-69267	45	71	aeruginosa	aeruginosa	PROPN
bjp-69267	45	72	atcc	atcc	PROPN
bjp-69267	45	73	27853	27853	NUM
bjp-69267	45	74	,	,	PUNCT
bjp-69267	45	75	and	and	CCONJ
bjp-69267	45	76	listeria	listeria	VERB
bjp-69267	45	77	monocytogenes	monocytogene	NOUN
bjp-69267	45	78	atcc	atcc	ADJ
bjp-69267	45	79	15313	15313	NUM
bjp-69267	45	80	,	,	PUNCT
bjp-69267	45	81	candida	candida	PROPN
bjp-69267	45	82	albicans	albican	VERB
bjp-69267	45	83	atcc	atcc	PROPN
bjp-69267	45	84	mya-2876	mya-2876	NOUN
bjp-69267	45	85	procedure	procedure	NOUN
bjp-69267	45	86	step	step	NOUN
bjp-69267	45	87	1	1	NUM
bjp-69267	45	88	:	:	PUNCT
bjp-69267	45	89	gram	gram	NUM
bjp-69267	45	90	-	-	PUNCT
bjp-69267	45	91	positive	positive	ADJ
bjp-69267	45	92	and	and	CCONJ
bjp-69267	45	93	gram	gram	NOUN
bjp-69267	45	94	-	-	PUNCT
bjp-69267	45	95	negative	negative	ADJ
bjp-69267	45	96	bacteria	bacteria	NOUN
bjp-69267	45	97	obtained	obtain	VERB
bjp-69267	45	98	from	from	ADP
bjp-69267	45	99	24	24	NUM
bjp-69267	45	100	-	-	PUNCT
bjp-69267	45	101	hour	hour	NOUN
bjp-69267	45	102	cultures	culture	NOUN
bjp-69267	45	103	and	and	CCONJ
bjp-69267	45	104	suspended	suspend	VERB
bjp-69267	45	105	in	in	ADP
bjp-69267	45	106	sterile	sterile	ADJ
bjp-69267	45	107	saline	saline	NOUN
bjp-69267	45	108	to	to	PART
bjp-69267	45	109	achieve	achieve	VERB
bjp-69267	45	110	concentrations	concentration	NOUN
bjp-69267	45	111	of	of	ADP
bjp-69267	45	112	approximately	approximately	ADV
bjp-69267	45	113	108	108	NUM
bjp-69267	45	114	cfu	cfu	NOUN
bjp-69267	45	115	/	/	SYM
bjp-69267	45	116	ml	ml	NOUN
bjp-69267	45	117	relative	relative	ADJ
bjp-69267	45	118	to	to	ADP
bjp-69267	45	119	0.5	0.5	NUM
bjp-69267	45	120	mcfarland	mcfarland	PROPN
bjp-69267	45	121	standard	standard	NOUN
bjp-69267	45	122	.	.	PUNCT
bjp-69267	46	1	a	a	DET
bjp-69267	46	2	suspension	suspension	NOUN
bjp-69267	46	3	of	of	ADP
bjp-69267	46	4	candida	candida	NOUN
bjp-69267	46	5	albicans	albican	NOUN
bjp-69267	46	6	(	(	PUNCT
bjp-69267	46	7	1	1	NUM
bjp-69267	46	8	×	×	NOUN
bjp-69267	46	9	106	106	NUM
bjp-69267	46	10	cells	cell	NOUN
bjp-69267	46	11	/	/	SYM
bjp-69267	46	12	ml	ml	NOUN
bjp-69267	46	13	)	)	PUNCT
bjp-69267	46	14	in	in	ADP
bjp-69267	46	15	saline	saline	ADJ
bjp-69267	46	16	water	water	NOUN
bjp-69267	46	17	was	be	AUX
bjp-69267	46	18	prepared	prepare	VERB
bjp-69267	46	19	for	for	ADP
bjp-69267	46	20	fungal	fungal	ADJ
bjp-69267	46	21	culture	culture	NOUN
bjp-69267	46	22	step	step	NOUN
bjp-69267	46	23	2	2	NUM
bjp-69267	46	24	:	:	PUNCT
bjp-69267	46	25	plates	plate	NOUN
bjp-69267	46	26	were	be	AUX
bjp-69267	46	27	prepared	prepare	VERB
bjp-69267	46	28	using	use	VERB
bjp-69267	46	29	20	20	NUM
bjp-69267	46	30	ml	ml	NOUN
bjp-69267	46	31	sterile	sterile	ADJ
bjp-69267	46	32	muellerhinton	muellerhinton	NOUN
bjp-69267	46	33	agar	agar	NOUN
bjp-69267	46	34	(	(	PUNCT
bjp-69267	46	35	2	2	NUM
bjp-69267	46	36	%	%	NOUN
bjp-69267	46	37	beef	beef	NOUN
bjp-69267	46	38	extract	extract	NOUN
bjp-69267	46	39	,	,	PUNCT
bjp-69267	46	40	17.5	17.5	NUM
bjp-69267	46	41	%	%	NOUN
bjp-69267	46	42	acid	acid	NOUN
bjp-69267	46	43	hydrolysate	hydrolysate	NOUN
bjp-69267	46	44	of	of	ADP
bjp-69267	46	45	casein	casein	NOUN
bjp-69267	46	46	,	,	PUNCT
bjp-69267	46	47	1.5	1.5	NUM
bjp-69267	46	48	%	%	NOUN
bjp-69267	46	49	starch	starch	NOUN
bjp-69267	46	50	,	,	PUNCT
bjp-69267	46	51	and	and	CCONJ
bjp-69267	46	52	1.5	1.5	NUM
bjp-69267	46	53	%	%	NOUN
bjp-69267	46	54	agar	agar	NOUN
bjp-69267	46	55	)	)	PUNCT
bjp-69267	46	56	for	for	ADP
bjp-69267	46	57	antibacterial	antibacterial	ADJ
bjp-69267	46	58	activity	activity	NOUN
bjp-69267	46	59	and	and	CCONJ
bjp-69267	46	60	sabouraud	sabouraud	NOUN
bjp-69267	46	61	agar	agar	NOUN
bjp-69267	46	62	medium	medium	NOUN
bjp-69267	46	63	(	(	PUNCT
bjp-69267	46	64	1	1	NUM
bjp-69267	46	65	%	%	NOUN
bjp-69267	46	66	yeast	yeast	NOUN
bjp-69267	46	67	extract	extract	NOUN
bjp-69267	46	68	,	,	PUNCT
bjp-69267	46	69	2	2	NUM
bjp-69267	46	70	%	%	NOUN
bjp-69267	46	71	peptone	peptone	NOUN
bjp-69267	46	72	,	,	PUNCT
bjp-69267	46	73	2	2	NUM
bjp-69267	46	74	%	%	NOUN
bjp-69267	46	75	dextrose	dextrose	NOUN
bjp-69267	46	76	,	,	PUNCT
bjp-69267	46	77	and	and	CCONJ
bjp-69267	46	78	2	2	NUM
bjp-69267	46	79	%	%	NOUN
bjp-69267	46	80	agar	agar	NOUN
bjp-69267	46	81	)	)	PUNCT
bjp-69267	46	82	for	for	ADP
bjp-69267	46	83	antifungal	antifungal	ADJ
bjp-69267	46	84	activity	activity	NOUN
bjp-69267	46	85	step	step	NOUN
bjp-69267	46	86	3	3	NUM
bjp-69267	46	87	:	:	PUNCT
bjp-69267	46	88	the	the	DET
bjp-69267	46	89	surface	surface	NOUN
bjp-69267	46	90	of	of	ADP
bjp-69267	46	91	the	the	DET
bjp-69267	46	92	plates	plate	NOUN
bjp-69267	46	93	was	be	AUX
bjp-69267	46	94	inoculated	inoculate	VERB
bjp-69267	46	95	with	with	ADP
bjp-69267	46	96	a	a	DET
bjp-69267	46	97	sterile	sterile	ADJ
bjp-69267	46	98	swab	swab	NOUN
bjp-69267	46	99	containing	contain	VERB
bjp-69267	46	100	the	the	DET
bjp-69267	46	101	saline	saline	ADJ
bjp-69267	46	102	suspension	suspension	NOUN
bjp-69267	46	103	of	of	ADP
bjp-69267	46	104	bacteria	bacteria	NOUN
bjp-69267	46	105	and	and	CCONJ
bjp-69267	46	106	allowed	allow	VERB
bjp-69267	46	107	to	to	PART
bjp-69267	46	108	dry	dry	VERB
bjp-69267	46	109	.	.	PUNCT
bjp-69267	47	1	step	step	NOUN
bjp-69267	47	2	4	4	NUM
bjp-69267	47	3	:	:	PUNCT
bjp-69267	47	4	previously	previously	ADV
bjp-69267	47	5	prepared	prepared	ADJ
bjp-69267	47	6	wells	well	NOUN
bjp-69267	47	7	,	,	PUNCT
bjp-69267	47	8	6.0	6.0	NUM
bjp-69267	47	9	mm	mm	NOUN
bjp-69267	47	10	in	in	ADP
bjp-69267	47	11	diameter	diameter	NOUN
bjp-69267	47	12	,	,	PUNCT
bjp-69267	47	13	containing	contain	VERB
bjp-69267	47	14	50	50	NUM
bjp-69267	47	15	ul	ul	NOUN
bjp-69267	47	16	of	of	ADP
bjp-69267	47	17	a	a	DET
bjp-69267	47	18	methanolic	methanolic	NOUN
bjp-69267	47	19	solution	solution	NOUN
bjp-69267	47	20	of	of	ADP
bjp-69267	47	21	test	test	NOUN
bjp-69267	47	22	compound	compound	NOUN
bjp-69267	47	23	of	of	ADP
bjp-69267	47	24	different	different	ADJ
bjp-69267	47	25	concentrations	concentration	NOUN
bjp-69267	47	26	,	,	PUNCT
bjp-69267	47	27	were	be	AUX
bjp-69267	47	28	placed	place	VERB
bjp-69267	47	29	on	on	ADP
bjp-69267	47	30	the	the	DET
bjp-69267	47	31	agar	agar	NOUN
bjp-69267	47	32	surface	surface	NOUN
bjp-69267	47	33	.	.	PUNCT
bjp-69267	48	1	step	step	NOUN
bjp-69267	48	2	5	5	NUM
bjp-69267	48	3	:	:	PUNCT
bjp-69267	48	4	the	the	DET
bjp-69267	48	5	antibiotic	antibiotic	ADJ
bjp-69267	48	6	discs	disc	NOUN
bjp-69267	48	7	(	(	PUNCT
bjp-69267	48	8	gentamicin	gentamicin	NOUN
bjp-69267	48	9	,	,	PUNCT
bjp-69267	48	10	pipemidic	pipemidic	ADJ
bjp-69267	48	11	acid	acid	NOUN
bjp-69267	48	12	,	,	PUNCT
bjp-69267	48	13	cefazolin	cefazolin	NOUN
bjp-69267	48	14	,	,	PUNCT
bjp-69267	48	15	and	and	CCONJ
bjp-69267	48	16	colistin	colistin	NOUN
bjp-69267	48	17	)	)	PUNCT
bjp-69267	48	18	of	of	ADP
bjp-69267	48	19	6.0	6.0	NUM
bjp-69267	48	20	mm	mm	NOUN
bjp-69267	48	21	diameter	diameter	NOUN
bjp-69267	48	22	,	,	PUNCT
bjp-69267	48	23	containing	contain	VERB
bjp-69267	48	24	10	10	NUM
bjp-69267	48	25	to	to	PART
bjp-69267	48	26	50	50	NUM
bjp-69267	48	27	µg	µg	NOUN
bjp-69267	48	28	of	of	ADP
bjp-69267	48	29	active	active	ADJ
bjp-69267	48	30	substance	substance	NOUN
bjp-69267	48	31	per	per	ADP
bjp-69267	48	32	disc	disc	NOUN
bjp-69267	48	33	were	be	AUX
bjp-69267	48	34	placed	place	VERB
bjp-69267	48	35	on	on	ADP
bjp-69267	48	36	the	the	DET
bjp-69267	48	37	agar	agar	NOUN
bjp-69267	48	38	surface	surface	NOUN
bjp-69267	48	39	step	step	NOUN
bjp-69267	48	40	6	6	NUM
bjp-69267	48	41	:	:	PUNCT
bjp-69267	48	42	the	the	DET
bjp-69267	48	43	plates	plate	NOUN
bjp-69267	48	44	were	be	AUX
bjp-69267	48	45	then	then	ADV
bjp-69267	48	46	incubated	incubate	VERB
bjp-69267	48	47	at	at	ADP
bjp-69267	48	48	37ºc	37ºc	ADJ
bjp-69267	48	49	and	and	CCONJ
bjp-69267	48	50	after	after	ADP
bjp-69267	48	51	24	24	NUM
bjp-69267	48	52	hours	hour	NOUN
bjp-69267	48	53	,	,	PUNCT
bjp-69267	48	54	clear	clear	ADJ
bjp-69267	48	55	zones	zone	NOUN
bjp-69267	48	56	of	of	ADP
bjp-69267	48	57	inhibition	inhibition	NOUN
bjp-69267	48	58	were	be	AUX
bjp-69267	48	59	observed	observe	VERB
bjp-69267	48	60	around	around	ADP
bjp-69267	48	61	the	the	DET
bjp-69267	48	62	disks	disk	NOUN
bjp-69267	48	63	and	and	CCONJ
bjp-69267	48	64	measured	measure	VERB
bjp-69267	48	65	using	use	VERB
bjp-69267	48	66	a	a	DET
bjp-69267	48	67	caliper	caliper	NOUN
bjp-69267	48	68	.	.	PUNCT
bjp-69267	49	1	references	reference	NOUN
bjp-69267	49	2	ignatov	ignatov	ADV
bjp-69267	49	3	,	,	PUNCT
bjp-69267	49	4	2021	2021	NUM
bjp-69267	49	5	;	;	PUNCT
bjp-69267	49	6	lake	lake	PROPN
bjp-69267	49	7	et	et	PROPN
bjp-69267	49	8	al	al	PROPN
bjp-69267	49	9	.	.	PROPN
bjp-69267	49	10	,	,	PUNCT
bjp-69267	49	11	2023	2023	NUM
bjp-69267	49	12	;	;	PUNCT
bjp-69267	49	13	vică	vică	NOUN
bjp-69267	49	14	et	et	PROPN
bjp-69267	49	15	al	al	PROPN
bjp-69267	49	16	.	.	PROPN
bjp-69267	49	17	,	,	PUNCT
bjp-69267	49	18	2021	2021	NUM
bjp-69267	49	19	;	;	PUNCT
bjp-69267	49	20	references	reference	NOUN
bjp-69267	49	21	(	(	PUNCT
bjp-69267	49	22	video	video	NOUN
bjp-69267	49	23	)	)	PUNCT
bjp-69267	49	24	rattanasuk	rattanasuk	NOUN
bjp-69267	49	25	et	et	PROPN
bjp-69267	49	26	al	al	PROPN
bjp-69267	49	27	.	.	PROPN
bjp-69267	49	28	,	,	PUNCT
bjp-69267	49	29	2021	2021	NUM
bjp-69267	49	30	;	;	PUNCT
bjp-69267	49	31	sundar	sundar	NOUN
bjp-69267	49	32	and	and	CCONJ
bjp-69267	49	33	arunachalam	arunachalam	PROPN
bjp-69267	49	34	,	,	PUNCT
bjp-69267	49	35	2023	2023	NUM
bjp-69267	49	36	nmr	nmr	NOUN
bjp-69267	49	37	experiments	experiment	NOUN
bjp-69267	49	38	(	(	PUNCT
bjp-69267	49	39	1h	1h	NUM
bjp-69267	49	40	nmr	nmr	NOUN
bjp-69267	49	41	and	and	CCONJ
bjp-69267	49	42	dept-135	dept-135	NOUN
bjp-69267	49	43	)	)	PUNCT
bjp-69267	49	44	were	be	AUX
bjp-69267	49	45	recorded	record	VERB
bjp-69267	49	46	at	at	ADP
bjp-69267	49	47	room	room	NOUN
bjp-69267	49	48	temperature	temperature	NOUN
bjp-69267	49	49	on	on	ADP
bjp-69267	49	50	a	a	DET
bjp-69267	49	51	bruker	bruker	ADJ
bjp-69267	49	52	ac300	ac300	NOUN
bjp-69267	49	53	instrument	instrument	NOUN
bjp-69267	49	54	using	use	VERB
bjp-69267	49	55	dmso	dmso	NOUN
bjp-69267	49	56	-	-	PUNCT
bjp-69267	49	57	d6	d6	NOUN
bjp-69267	49	58	as	as	ADP
bjp-69267	49	59	a	a	DET
bjp-69267	49	60	solvent	solvent	NOUN
bjp-69267	49	61	and	and	CCONJ
bjp-69267	49	62	tms	tms	PROPN
bjp-69267	49	63	as	as	ADP
bjp-69267	49	64	an	an	DET
bjp-69267	49	65	internal	internal	ADJ
bjp-69267	49	66	standard	standard	NOUN
bjp-69267	49	67	.	.	PUNCT
bjp-69267	50	1	chemical	chemical	ADJ
bjp-69267	50	2	shifts	shift	NOUN
bjp-69267	50	3	(	(	PUNCT
bjp-69267	50	4	δ	δ	NOUN
bjp-69267	50	5	)	)	PUNCT
bjp-69267	50	6	and	and	CCONJ
bjp-69267	50	7	coupling	couple	VERB
bjp-69267	50	8	constants	constant	NOUN
bjp-69267	50	9	(	(	PUNCT
bjp-69267	50	10	j	j	NOUN
bjp-69267	50	11	)	)	PUNCT
bjp-69267	50	12	are	be	AUX
bjp-69267	50	13	reported	report	VERB
bjp-69267	50	14	in	in	ADP
bjp-69267	50	15	ppm	ppm	NOUN
bjp-69267	50	16	,	,	PUNCT
bjp-69267	50	17	and	and	CCONJ
bjp-69267	50	18	hz	hz	VERB
bjp-69267	50	19	,	,	PUNCT
bjp-69267	50	20	respectively	respectively	ADV
bjp-69267	50	21	.	.	PUNCT
bjp-69267	51	1	in	in	ADP
bjp-69267	51	2	silico	silico	NOUN
bjp-69267	51	3	drug	drug	NOUN
bjp-69267	51	4	-	-	PUNCT
bjp-69267	51	5	likeness	likeness	NOUN
bjp-69267	51	6	and	and	CCONJ
bjp-69267	51	7	toxicity	toxicity	NOUN
bjp-69267	51	8	predictions	prediction	NOUN
bjp-69267	51	9	the	the	DET
bjp-69267	51	10	swissadme	swissadme	PROPN
bjp-69267	51	11	platform	platform	NOUN
bjp-69267	51	12	(	(	PUNCT
bjp-69267	51	13	http://www.swissadme.ch/index.php	http://www.swissadme.ch/index.php	INTJ
bjp-69267	51	14	)	)	PUNCT
bjp-69267	51	15	was	be	AUX
bjp-69267	51	16	used	use	VERB
bjp-69267	51	17	to	to	PART
bjp-69267	51	18	provide	provide	VERB
bjp-69267	51	19	insights	insight	NOUN
bjp-69267	51	20	into	into	ADP
bjp-69267	51	21	adme	adme	NOUN
bjp-69267	51	22	(	(	PUNCT
bjp-69267	51	23	absorption	absorption	NOUN
bjp-69267	51	24	,	,	PUNCT
bjp-69267	51	25	distribution	distribution	NOUN
bjp-69267	51	26	,	,	PUNCT
bjp-69267	51	27	metabolism	metabolism	NOUN
bjp-69267	51	28	,	,	PUNCT
bjp-69267	51	29	and	and	CCONJ
bjp-69267	51	30	excretion	excretion	NOUN
bjp-69267	51	31	)	)	PUNCT
bjp-69267	51	32	parameters	parameter	NOUN
bjp-69267	51	33	,	,	PUNCT
bjp-69267	51	34	pharmacokinetic	pharmacokinetic	ADJ
bjp-69267	51	35	properties	property	NOUN
bjp-69267	51	36	,	,	PUNCT
bjp-69267	51	37	drug	drug	NOUN
bjp-69267	51	38	-	-	PUNCT
bjp-69267	51	39	likeness	likeness	NOUN
bjp-69267	51	40	attributes	attribute	NOUN
bjp-69267	51	41	,	,	PUNCT
bjp-69267	51	42	and	and	CCONJ
bjp-69267	51	43	the	the	DET
bjp-69267	51	44	suitability	suitability	NOUN
bjp-69267	51	45	of	of	ADP
bjp-69267	51	46	compounds	compound	NOUN
bjp-69267	51	47	from	from	ADP
bjp-69267	51	48	a	a	DET
bjp-69267	51	49	medicinal	medicinal	ADJ
bjp-69267	51	50	chemistry	chemistry	NOUN
bjp-69267	51	51	perspective	perspective	NOUN
bjp-69267	51	52	(	(	PUNCT
bjp-69267	51	53	daina	daina	PROPN
bjp-69267	51	54	et	et	PROPN
bjp-69267	51	55	al	al	PROPN
bjp-69267	51	56	.	.	PROPN
bjp-69267	51	57	,	,	PUNCT
bjp-69267	51	58	2017	2017	NUM
bjp-69267	51	59	)	)	PUNCT
bjp-69267	51	60	.	.	PUNCT
bjp-69267	52	1	the	the	DET
bjp-69267	52	2	assessment	assessment	NOUN
bjp-69267	52	3	of	of	ADP
bjp-69267	52	4	toxicity	toxicity	NOUN
bjp-69267	52	5	was	be	AUX
bjp-69267	52	6	carried	carry	VERB
bjp-69267	52	7	out	out	ADP
bjp-69267	52	8	using	use	VERB
bjp-69267	52	9	the	the	DET
bjp-69267	52	10	emoltox	emoltox	ADJ
bjp-69267	52	11	web	web	NOUN
bjp-69267	52	12	tool	tool	NOUN
bjp-69267	52	13	,	,	PUNCT
bjp-69267	52	14	which	which	PRON
bjp-69267	52	15	identified	identify	VERB
bjp-69267	52	16	potential	potential	ADJ
bjp-69267	52	17	toxicities	toxicity	NOUN
bjp-69267	52	18	by	by	ADP
bjp-69267	52	19	analyzing	analyze	VERB
bjp-69267	52	20	various	various	ADJ
bjp-69267	52	21	components	component	NOUN
bjp-69267	52	22	within	within	ADP
bjp-69267	52	23	the	the	DET
bjp-69267	52	24	drug	drug	NOUN
bjp-69267	52	25	(	(	PUNCT
bjp-69267	52	26	ji	ji	X
bjp-69267	52	27	et	et	PROPN
bjp-69267	52	28	al	al	PROPN
bjp-69267	52	29	.	.	PROPN
bjp-69267	52	30	,	,	PUNCT
bjp-69267	52	31	2018	2018	NUM
bjp-69267	52	32	)	)	PUNCT
bjp-69267	52	33	.	.	PUNCT
bjp-69267	53	1	molecular	molecular	ADJ
bjp-69267	53	2	docking	docking	NOUN
bjp-69267	53	3	analysis	analysis	NOUN
bjp-69267	53	4	the	the	DET
bjp-69267	53	5	ligand	ligand	ADJ
bjp-69267	53	6	pyrazoline	pyrazoline	NOUN
bjp-69267	53	7	carboxamide	carboxamide	NOUN
bjp-69267	53	8	was	be	AUX
bjp-69267	53	9	designed	design	VERB
bjp-69267	53	10	using	use	VERB
bjp-69267	53	11	marvin	marvin	PROPN
bjp-69267	53	12	sketch	sketch	PROPN
bjp-69267	53	13	version	version	PROPN
bjp-69267	53	14	5.10.0	5.10.0	NUM
bjp-69267	53	15	and	and	CCONJ
bjp-69267	53	16	saved	save	VERB
bjp-69267	53	17	in	in	ADP
bjp-69267	53	18	.pdb	.pdb	PROPN
bjp-69267	53	19	format	format	NOUN
bjp-69267	53	20	.	.	PUNCT
bjp-69267	54	1	ampicillin	ampicillin	PROPN
bjp-69267	54	2	(	(	PUNCT
bjp-69267	54	3	cid	cid	NOUN
bjp-69267	54	4	:	:	PUNCT
bjp-69267	54	5	6249	6249	NUM
bjp-69267	54	6	)	)	PUNCT
bjp-69267	54	7	and	and	CCONJ
bjp-69267	54	8	clorobiocin	clorobiocin	PROPN
bjp-69267	54	9	(	(	PUNCT
bjp-69267	54	10	cid	cid	PROPN
bjp-69267	54	11	:	:	PUNCT
bjp-69267	54	12	54706138	54706138	NUM
bjp-69267	54	13	)	)	PUNCT
bjp-69267	54	14	used	use	VERB
bjp-69267	54	15	as	as	ADP
bjp-69267	54	16	control	control	NOUN
bjp-69267	54	17	ligands	ligand	NOUN
bjp-69267	54	18	(	(	PUNCT
bjp-69267	54	19	antibiotics	antibiotic	NOUN
bjp-69267	54	20	)	)	PUNCT
bjp-69267	54	21	were	be	AUX
bjp-69267	54	22	obtained	obtain	VERB
bjp-69267	54	23	from	from	ADP
bjp-69267	54	24	the	the	DET
bjp-69267	54	25	pubchem	pubchem	NOUN
bjp-69267	54	26	database	database	NOUN
bjp-69267	54	27	(	(	PUNCT
bjp-69267	54	28	www.pubchem.ncbi.nlm.nih.gov	www.pubchem.ncbi.nlm.nih.gov	NOUN
bjp-69267	54	29	)	)	PUNCT
bjp-69267	54	30	.	.	PUNCT
bjp-69267	55	1	these	these	DET
bjp-69267	55	2	files	file	NOUN
bjp-69267	55	3	were	be	AUX
bjp-69267	55	4	then	then	ADV
bjp-69267	55	5	processed	process	VERB
bjp-69267	55	6	with	with	ADP
bjp-69267	55	7	autodock	autodock	NOUN
bjp-69267	55	8	tools	tool	NOUN
bjp-69267	55	9	to	to	PART
bjp-69267	55	10	generate	generate	VERB
bjp-69267	55	11	pdbqt	pdbqt	ADJ
bjp-69267	55	12	files	file	NOUN
bjp-69267	55	13	for	for	ADP
bjp-69267	55	14	molecular	molecular	ADJ
bjp-69267	55	15	docking	docking	NOUN
bjp-69267	55	16	using	use	VERB
bjp-69267	55	17	autodock	autodock	PROPN
bjp-69267	55	18	vina	vina	NOUN
bjp-69267	55	19	(	(	PUNCT
bjp-69267	55	20	trott	trott	PROPN
bjp-69267	55	21	and	and	CCONJ
bjp-69267	55	22	olson	olson	NOUN
bjp-69267	55	23	,	,	PUNCT
bjp-69267	55	24	2010	2010	NUM
bjp-69267	55	25	)	)	PUNCT
bjp-69267	55	26	.	.	PUNCT
bjp-69267	56	1	the	the	DET
bjp-69267	56	2	crystal	crystal	NOUN
bjp-69267	56	3	structures	structure	NOUN
bjp-69267	56	4	of	of	ADP
bjp-69267	56	5	the	the	DET
bjp-69267	56	6	target	target	NOUN
bjp-69267	56	7	proteins	protein	NOUN
bjp-69267	56	8	,	,	PUNCT
bjp-69267	56	9	dna	dna	NOUN
bjp-69267	56	10	gyrase	gyrase	NOUN
bjp-69267	56	11	(	(	PUNCT
bjp-69267	56	12	pdb	pdb	PROPN
bjp-69267	56	13	i	i	PROPN
bjp-69267	56	14	d	d	PROPN
bjp-69267	56	15	:	:	PUNCT
bjp-69267	56	16	1kzn	1kzn	NUM
bjp-69267	56	17	)	)	PUNCT
bjp-69267	56	18	and	and	CCONJ
bjp-69267	56	19	pbp4	pbp4	NOUN
bjp-69267	56	20	(	(	PUNCT
bjp-69267	56	21	pdb	pdb	PROPN
bjp-69267	56	22	i	i	PROPN
bjp-69267	56	23	d	d	PROPN
bjp-69267	56	24	:	:	PUNCT
bjp-69267	56	25	3hun	3hun	NUM
bjp-69267	56	26	,	,	PUNCT
bjp-69267	56	27	pdb	pdb	PROPN
bjp-69267	56	28	i	i	PROPN
bjp-69267	56	29	d	d	PROPN
bjp-69267	56	30	:	:	PUNCT
bjp-69267	56	31	7kcy	7kcy	NUM
bjp-69267	56	32	)	)	PUNCT
bjp-69267	56	33	,	,	PUNCT
bjp-69267	56	34	and	and	CCONJ
bjp-69267	56	35	cyp51	cyp51	PROPN
bjp-69267	56	36	(	(	PUNCT
bjp-69267	56	37	pdbid	pdbid	NOUN
bjp-69267	56	38	:	:	PUNCT
bjp-69267	56	39	5tz1	5tz1	NUM
bjp-69267	56	40	)	)	PUNCT
bjp-69267	56	41	were	be	AUX
bjp-69267	56	42	obtained	obtain	VERB
bjp-69267	56	43	from	from	ADP
bjp-69267	56	44	the	the	DET
bjp-69267	56	45	website	website	NOUN
bjp-69267	56	46	www.rcsb.org	www.rcsb.org	X
bjp-69267	56	47	.	.	PUNCT
bjp-69267	57	1	water	water	NOUN
bjp-69267	57	2	molecules	molecule	NOUN
bjp-69267	57	3	were	be	AUX
bjp-69267	57	4	removed	remove	VERB
bjp-69267	57	5	,	,	PUNCT
bjp-69267	57	6	and	and	CCONJ
bjp-69267	57	7	hydrogen	hydrogen	NOUN
bjp-69267	57	8	atoms	atom	NOUN
bjp-69267	57	9	were	be	AUX
bjp-69267	57	10	added	add	VERB
bjp-69267	57	11	to	to	ADP
bjp-69267	57	12	the	the	DET
bjp-69267	57	13	protein	protein	NOUN
bjp-69267	57	14	structure	structure	NOUN
bjp-69267	57	15	.	.	PUNCT
bjp-69267	58	1	docking	dock	VERB
bjp-69267	58	2	calculations	calculation	NOUN
bjp-69267	58	3	were	be	AUX
bjp-69267	58	4	performed	perform	VERB
bjp-69267	58	5	using	use	VERB
bjp-69267	58	6	autodock	autodock	PROPN
bjp-69267	58	7	vina	vina	PROPN
bjp-69267	58	8	integrated	integrate	VERB
bjp-69267	58	9	into	into	ADP
bjp-69267	58	10	pyrx	pyrx	NOUN
bjp-69267	58	11	virtual	virtual	ADJ
bjp-69267	58	12	screening	screening	NOUN
bjp-69267	58	13	tool	tool	NOUN
bjp-69267	58	14	v.8	v.8	NOUN
bjp-69267	58	15	.	.	PUNCT
bjp-69267	59	1	the	the	DET
bjp-69267	59	2	suitable	suitable	ADJ
bjp-69267	59	3	binding	bind	VERB
bjp-69267	59	4	area	area	NOUN
bjp-69267	59	5	was	be	AUX
bjp-69267	59	6	adjusted	adjust	VERB
bjp-69267	59	7	around	around	ADP
bjp-69267	59	8	the	the	DET
bjp-69267	59	9	active	active	ADJ
bjp-69267	59	10	binding	bind	VERB
bjp-69267	59	11	pockets	pocket	NOUN
bjp-69267	59	12	of	of	ADP
bjp-69267	59	13	the	the	DET
bjp-69267	59	14	proteins	protein	NOUN
bjp-69267	59	15	using	use	VERB
bjp-69267	59	16	the	the	DET
bjp-69267	59	17	autogrid	autogrid	ADJ
bjp-69267	59	18	tool	tool	NOUN
bjp-69267	59	19	integrated	integrate	VERB
bjp-69267	59	20	into	into	ADP
bjp-69267	59	21	pyrx	pyrx	NOUN
bjp-69267	59	22	where	where	SCONJ
bjp-69267	59	23	the	the	DET
bjp-69267	59	24	ligands	ligand	NOUN
bjp-69267	59	25	can	can	AUX
bjp-69267	59	26	search	search	VERB
bjp-69267	59	27	for	for	ADP
bjp-69267	59	28	better	well	ADV
bjp-69267	59	29	binding	bind	VERB
bjp-69267	59	30	with	with	ADP
bjp-69267	59	31	minimum	minimum	ADJ
bjp-69267	59	32	energy	energy	NOUN
bjp-69267	59	33	by	by	ADP
bjp-69267	59	34	allocating	allocate	VERB
bjp-69267	59	35	x	x	PROPN
bjp-69267	59	36	,	,	PUNCT
bjp-69267	59	37	y	y	PROPN
bjp-69267	59	38	,	,	PUNCT
bjp-69267	59	39	and	and	CCONJ
bjp-69267	59	40	z	z	NOUN
bjp-69267	59	41	-	-	PUNCT
bjp-69267	59	42	axis	axis	NOUN
bjp-69267	59	43	with	with	ADP
bjp-69267	59	44	suitable	suitable	ADJ
bjp-69267	59	45	spacing	spacing	NOUN
bjp-69267	59	46	.	.	PUNCT
bjp-69267	60	1	for	for	ADP
bjp-69267	60	2	the	the	DET
bjp-69267	60	3	dna	dna	PROPN
bjp-69267	60	4	gyrase	gyrase	NOUN
bjp-69267	60	5	,	,	PUNCT
bjp-69267	60	6	the	the	DET
bjp-69267	60	7	grid	grid	NOUN
bjp-69267	60	8	box	box	PROPN
bjp-69267	60	9	was	be	AUX
bjp-69267	60	10	set	set	VERB
bjp-69267	60	11	to	to	ADP
bjp-69267	60	12	25	25	NUM
bjp-69267	60	13	å	å	PROPN
bjp-69267	60	14	×	×	NOUN
bjp-69267	60	15	25	25	NUM
bjp-69267	60	16	å	å	PROPN
bjp-69267	60	17	×	×	NOUN
bjp-69267	60	18	25	25	NUM
bjp-69267	60	19	å	å	NOUN
bjp-69267	60	20	centered	center	VERB
bjp-69267	60	21	at	at	ADP
bjp-69267	60	22	19.5403	19.5403	NUM
bjp-69267	60	23	,	,	PUNCT
bjp-69267	60	24	19	19	NUM
bjp-69267	60	25	.	.	NOUN
bjp-69267	60	26	16072	16072	NUM
bjp-69267	60	27	,	,	PUNCT
bjp-69267	60	28	43.3421	43.3421	NUM
bjp-69267	60	29	(	(	PUNCT
bjp-69267	60	30	x	x	NOUN
bjp-69267	60	31	,	,	PUNCT
bjp-69267	60	32	y	y	PROPN
bjp-69267	60	33	,	,	PUNCT
bjp-69267	60	34	z	z	NOUN
bjp-69267	60	35	coordinates	coordinate	NOUN
bjp-69267	60	36	)	)	PUNCT
bjp-69267	60	37	,	,	PUNCT
bjp-69267	60	38	for	for	ADP
bjp-69267	60	39	pbp4	pbp4	NOUN
bjp-69267	60	40	the	the	DET
bjp-69267	60	41	grid	grid	NOUN
bjp-69267	60	42	box	box	PROPN
bjp-69267	60	43	,	,	PUNCT
bjp-69267	60	44	was	be	AUX
bjp-69267	60	45	set	set	VERB
bjp-69267	60	46	to	to	ADP
bjp-69267	60	47	25	25	NUM
bjp-69267	60	48	å	å	PROPN
bjp-69267	60	49	×	×	NOUN
bjp-69267	60	50	25	25	NUM
bjp-69267	60	51	å	å	PROPN
bjp-69267	60	52	×	×	NOUN
bjp-69267	60	53	25	25	NUM
bjp-69267	60	54	å	å	NOUN
bjp-69267	60	55	centered	center	VERB
bjp-69267	60	56	at	at	ADP
bjp-69267	60	57	-33.6029	-33.6029	PUNCT
bjp-69267	60	58	,	,	PUNCT
bjp-69267	60	59	5.6410	5.6410	NUM
bjp-69267	60	60	,	,	PUNCT
bjp-69267	60	61	-18.1544	-18.1544	PUNCT
bjp-69267	60	62	(	(	PUNCT
bjp-69267	60	63	x	x	NOUN
bjp-69267	60	64	,	,	PUNCT
bjp-69267	60	65	y	y	PROPN
bjp-69267	60	66	,	,	PUNCT
bjp-69267	60	67	z	z	NOUN
bjp-69267	60	68	coordinates	coordinate	NOUN
bjp-69267	60	69	)	)	PUNCT
bjp-69267	60	70	,	,	PUNCT
bjp-69267	60	71	and	and	CCONJ
bjp-69267	60	72	for	for	ADP
bjp-69267	60	73	cyp51	cyp51	ADJ
bjp-69267	60	74	the	the	DET
bjp-69267	60	75	grid	grid	NOUN
bjp-69267	60	76	box	box	PROPN
bjp-69267	60	77	was	be	AUX
bjp-69267	60	78	set	set	VERB
bjp-69267	60	79	to	to	ADP
bjp-69267	60	80	25	25	NUM
bjp-69267	60	81	å	å	PROPN
bjp-69267	60	82	×	×	NOUN
bjp-69267	60	83	25	25	NUM
bjp-69267	60	84	å	å	PROPN
bjp-69267	60	85	×	×	NOUN
bjp-69267	60	86	25	25	NUM
bjp-69267	60	87	å	å	NOUN
bjp-69267	60	88	centered	center	VERB
bjp-69267	60	89	at	at	ADP
bjp-69267	60	90	6.5230	6.5230	NUM
bjp-69267	60	91	,	,	PUNCT
bjp-69267	60	92	7.9811	7.9811	NUM
bjp-69267	60	93	,	,	PUNCT
bjp-69267	60	94	11.0620	11.0620	NUM
bjp-69267	60	95	(	(	PUNCT
bjp-69267	60	96	x	x	NOUN
bjp-69267	60	97	,	,	PUNCT
bjp-69267	60	98	y	y	PROPN
bjp-69267	60	99	,	,	PUNCT
bjp-69267	60	100	z	z	NOUN
bjp-69267	60	101	coordinates	coordinate	NOUN
bjp-69267	60	102	)	)	PUNCT
bjp-69267	60	103	.	.	PUNCT
bjp-69267	61	1	the	the	DET
bjp-69267	61	2	docking	docking	NOUN
bjp-69267	61	3	analysis	analysis	NOUN
bjp-69267	61	4	was	be	AUX
bjp-69267	61	5	conducted	conduct	VERB
bjp-69267	61	6	on	on	ADP
bjp-69267	61	7	microsoft	microsoft	PROPN
bjp-69267	61	8	windows	windows	PROPN
bjp-69267	61	9	10	10	NUM
bjp-69267	61	10	professional	professional	ADJ
bjp-69267	61	11	version	version	NOUN
bjp-69267	61	12	,	,	PUNCT
bjp-69267	61	13	service	service	NOUN
bjp-69267	61	14	pack	pack	NOUN
bjp-69267	61	15	3	3	NUM
bjp-69267	61	16	with	with	ADP
bjp-69267	61	17	an	an	DET
bjp-69267	61	18	intel	intel	PROPN
bjp-69267	61	19	(	(	PUNCT
bjp-69267	61	20	r	r	NOUN
bjp-69267	61	21	)	)	PUNCT
bjp-69267	61	22	i3	i3	NOUN
bjp-69267	61	23	-	-	PUNCT
bjp-69267	61	24	7020u	7020u	NOUN
bjp-69267	61	25	cpu	cpu	NOUN
bjp-69267	61	26	@	@	ADP
bjp-69267	61	27	2.30	2.30	NUM
bjp-69267	61	28	ghz	ghz	NOUN
bjp-69267	61	29	and	and	CCONJ
bjp-69267	61	30	4.0	4.0	NUM
bjp-69267	61	31	gb	gb	NOUN
bjp-69267	61	32	of	of	ADP
bjp-69267	61	33	ram	ram	NOUN
bjp-69267	61	34	.	.	PUNCT
bjp-69267	62	1	biovia	biovia	PROPN
bjp-69267	62	2	discovery	discovery	PROPN
bjp-69267	62	3	studio	studio	PROPN
bjp-69267	62	4	visualizer	visualizer	PROPN
bjp-69267	62	5	2021	2021	NUM
bjp-69267	62	6	was	be	AUX
bjp-69267	62	7	used	use	VERB
bjp-69267	62	8	to	to	PART
bjp-69267	62	9	analyze	analyze	VERB
bjp-69267	62	10	the	the	DET
bjp-69267	62	11	obtained	obtain	VERB
bjp-69267	62	12	conformations	conformation	NOUN
bjp-69267	62	13	of	of	ADP
bjp-69267	62	14	the	the	DET
bjp-69267	62	15	complex	complex	NOUN
bjp-69267	62	16	for	for	ADP
bjp-69267	62	17	binding	bind	VERB
bjp-69267	62	18	energy	energy	NOUN
bjp-69267	62	19	and	and	CCONJ
bjp-69267	62	20	docking	docking	NOUN
bjp-69267	62	21	arrangements	arrangement	NOUN
bjp-69267	62	22	.	.	PUNCT
bjp-69267	63	1	molecular	molecular	ADJ
bjp-69267	63	2	dynamics	dynamic	NOUN
bjp-69267	63	3	simulation	simulation	NOUN
bjp-69267	63	4	to	to	PART
bjp-69267	63	5	analyze	analyze	VERB
bjp-69267	63	6	the	the	DET
bjp-69267	63	7	stability	stability	NOUN
bjp-69267	63	8	and	and	CCONJ
bjp-69267	63	9	movement	movement	NOUN
bjp-69267	63	10	of	of	ADP
bjp-69267	63	11	the	the	DET
bjp-69267	63	12	proteinligand	proteinligand	NOUN
bjp-69267	63	13	combinations	combination	NOUN
bjp-69267	63	14	,	,	PUNCT
bjp-69267	63	15	the	the	DET
bjp-69267	63	16	docking	docking	NOUN
bjp-69267	63	17	arrangements	arrangement	NOUN
bjp-69267	63	18	were	be	AUX
bjp-69267	63	19	subjected	subject	VERB
bjp-69267	63	20	to	to	ADP
bjp-69267	63	21	molecular	molecular	ADJ
bjp-69267	63	22	dynamics	dynamic	NOUN
bjp-69267	63	23	simulations	simulation	NOUN
bjp-69267	63	24	.	.	PUNCT
bjp-69267	64	1	these	these	DET
bjp-69267	64	2	simulations	simulation	NOUN
bjp-69267	64	3	were	be	AUX
bjp-69267	64	4	performed	perform	VERB
bjp-69267	64	5	using	use	VERB
bjp-69267	64	6	the	the	DET
bjp-69267	64	7	imods	imod	NOUN
bjp-69267	64	8	server	server	NOUN
bjp-69267	64	9	,	,	PUNCT
bjp-69267	64	10	accessible	accessible	ADJ
bjp-69267	64	11	at	at	ADP
bjp-69267	64	12	http://imods.chaconlab.org	http://imods.chaconlab.org	PROPN
bjp-69267	64	13	(	(	PUNCT
bjp-69267	64	14	lópez	lópez	NOUN
bjp-69267	64	15	-	-	PUNCT
bjp-69267	64	16	blanco	blanco	PROPN
bjp-69267	64	17	et	et	PROPN
bjp-69267	64	18	al	al	PROPN
bjp-69267	64	19	.	.	PROPN
bjp-69267	64	20	,	,	PUNCT
bjp-69267	64	21	2014	2014	NUM
bjp-69267	64	22	)	)	PUNCT
bjp-69267	64	23	.	.	PUNCT
bjp-69267	65	1	the	the	DET
bjp-69267	65	2	imods	imod	NOUN
bjp-69267	65	3	server	server	NOUN
bjp-69267	65	4	assumes	assume	VERB
bjp-69267	65	5	a	a	DET
bjp-69267	65	6	critical	critical	ADJ
bjp-69267	65	7	role	role	NOUN
bjp-69267	65	8	in	in	ADP
bjp-69267	65	9	investigating	investigate	VERB
bjp-69267	65	10	diverse	diverse	ADJ
bjp-69267	65	11	patterns	pattern	NOUN
bjp-69267	65	12	of	of	ADP
bjp-69267	65	13	movement	movement	NOUN
bjp-69267	65	14	and	and	CCONJ
bjp-69267	65	15	generating	generate	VERB
bjp-69267	65	16	potential	potential	ADJ
bjp-69267	65	17	pathways	pathway	NOUN
bjp-69267	65	18	of	of	ADP
bjp-69267	65	19	transition	transition	NOUN
bjp-69267	65	20	between	between	ADP
bjp-69267	65	21	proteins	protein	NOUN
bjp-69267	65	22	that	that	PRON
bjp-69267	65	23	are	be	AUX
bjp-69267	65	24	structurally	structurally	ADV
bjp-69267	65	25	akin	akin	ADJ
bjp-69267	65	26	.	.	PUNCT
bjp-69267	66	1	among	among	ADP
bjp-69267	66	2	its	its	PRON
bjp-69267	66	3	functionalities	functionality	NOUN
bjp-69267	66	4	,	,	PUNCT
bjp-69267	66	5	the	the	DET
bjp-69267	66	6	imods	imod	NOUN
bjp-69267	66	7	server	server	NOUN
bjp-69267	66	8	assesses	assesse	NOUN
bjp-69267	66	9	protein	protein	NOUN
bjp-69267	66	10	stability	stability	NOUN
bjp-69267	66	11	by	by	ADP
bjp-69267	66	12	computing	compute	VERB
bjp-69267	66	13	the	the	DET
bjp-69267	66	14	internal	internal	ADJ
bjp-69267	66	15	coordinates	coordinate	NOUN
bjp-69267	66	16	of	of	ADP
bjp-69267	66	17	the	the	DET
bjp-69267	66	18	protein	protein	NOUN
bjp-69267	66	19	through	through	ADP
bjp-69267	66	20	normal	normal	ADJ
bjp-69267	66	21	mode	mode	NOUN
bjp-69267	66	22	analysis	analysis	NOUN
bjp-69267	66	23	(	(	PUNCT
bjp-69267	66	24	nma	nma	PROPN
bjp-69267	66	25	)	)	PUNCT
bjp-69267	66	26	.	.	PUNCT
bjp-69267	67	1	this	this	DET
bjp-69267	67	2	server	server	NOUN
bjp-69267	67	3	employs	employ	VERB
bjp-69267	67	4	various	various	ADJ
bjp-69267	67	5	measures	measure	NOUN
bjp-69267	67	6	to	to	PART
bjp-69267	67	7	depict	depict	VERB
bjp-69267	67	8	protein	protein	NOUN
bjp-69267	67	9	stability	stability	NOUN
bjp-69267	67	10	,	,	PUNCT
bjp-69267	67	11	encompassing	encompass	VERB
bjp-69267	67	12	a	a	DET
bjp-69267	67	13	plot	plot	NOUN
bjp-69267	67	14	of	of	ADP
bjp-69267	67	15	mainchain	mainchain	NOUN
bjp-69267	67	16	deformability	deformability	NOUN
bjp-69267	67	17	,	,	PUNCT
bjp-69267	67	18	b	b	NOUN
bjp-69267	67	19	-	-	PUNCT
bjp-69267	67	20	factor	factor	NOUN
bjp-69267	67	21	readings	reading	NOUN
bjp-69267	67	22	,	,	PUNCT
bjp-69267	67	23	eigenvalues	eigenvalue	NOUN
bjp-69267	67	24	,	,	PUNCT
bjp-69267	67	25	covariance	covariance	NOUN
bjp-69267	67	26	matrix	matrix	NOUN
bjp-69267	67	27	,	,	PUNCT
bjp-69267	67	28	and	and	CCONJ
bjp-69267	67	29	an	an	DET
bjp-69267	67	30	elastic	elastic	ADJ
bjp-69267	67	31	network	network	NOUN
bjp-69267	67	32	model	model	NOUN
bjp-69267	67	33	.	.	PUNCT
bjp-69267	68	1	statistical	statistical	ADJ
bjp-69267	68	2	analysis	analysis	NOUN
bjp-69267	68	3	the	the	DET
bjp-69267	68	4	results	result	NOUN
bjp-69267	68	5	were	be	AUX
bjp-69267	68	6	obtained	obtain	VERB
bjp-69267	68	7	in	in	ADP
bjp-69267	68	8	triplicate	triplicate	NOUN
bjp-69267	68	9	(	(	PUNCT
bjp-69267	68	10	n=3	n=3	NOUN
bjp-69267	68	11	)	)	PUNCT
bjp-69267	68	12	and	and	CCONJ
bjp-69267	68	13	presented	present	VERB
bjp-69267	68	14	as	as	ADP
bjp-69267	68	15	the	the	DET
bjp-69267	68	16	mean	mean	PROPN
bjp-69267	68	17	±	±	NUM
bjp-69267	68	18	standard	standard	ADJ
bjp-69267	68	19	deviation	deviation	NOUN
bjp-69267	68	20	.	.	PUNCT
bjp-69267	69	1	statistical	statistical	ADJ
bjp-69267	69	2	analysis	analysis	NOUN
bjp-69267	69	3	was	be	AUX
bjp-69267	69	4	performed	perform	VERB
bjp-69267	69	5	using	use	VERB
bjp-69267	69	6	sigma	sigma	NOUN
bjp-69267	69	7	-	-	PUNCT
bjp-69267	69	8	plot	plot	NOUN
bjp-69267	69	9	for	for	ADP
bjp-69267	69	10	windows	window	NOUN
bjp-69267	69	11	version	version	NOUN
bjp-69267	69	12	11.0	11.0	NUM
bjp-69267	69	13	.	.	PUNCT
bjp-69267	70	1	statistical	statistical	ADJ
bjp-69267	70	2	significance	significance	NOUN
bjp-69267	70	3	was	be	AUX
bjp-69267	70	4	performed	perform	VERB
bjp-69267	70	5	by	by	ADP
bjp-69267	70	6	a	a	DET
bjp-69267	70	7	one	one	NUM
bjp-69267	70	8	-	-	PUNCT
bjp-69267	70	9	way	way	NOUN
bjp-69267	70	10	anova	anova	X
bjp-69267	70	11	(	(	PUNCT
bjp-69267	70	12	analysis	analysis	NOUN
bjp-69267	70	13	of	of	ADP
bjp-69267	70	14	variance	variance	NOUN
bjp-69267	70	15	)	)	PUNCT
bjp-69267	70	16	test	test	NOUN
bjp-69267	70	17	followed	follow	VERB
bjp-69267	70	18	by	by	ADP
bjp-69267	70	19	a	a	DET
bjp-69267	70	20	post	post	ADJ
bjp-69267	70	21	-	-	ADJ
bjp-69267	70	22	hoc	hoc	ADJ
bjp-69267	70	23	tukey	tukey	NOUN
bjp-69267	70	24	test	test	NOUN
bjp-69267	70	25	.	.	PUNCT
bjp-69267	71	1	results	result	VERB
bjp-69267	71	2	synthesis	synthesis	NOUN
bjp-69267	71	3	of	of	ADP
bjp-69267	71	4	5-(4-(dimethylamino)phenyl)-3	5-(4-(dimethylamino)phenyl)-3	PROPN
bjp-69267	71	5	-	-	PUNCT
bjp-69267	71	6	phenyl-4,5	phenyl-4,5	NOUN
bjp-69267	71	7	-dihydro-1h	-dihydro-1h	NUM
bjp-69267	71	8	-	-	PUNCT
bjp-69267	71	9	pyrazole-1	pyrazole-1	NOUN
bjp-69267	71	10	-	-	NOUN
bjp-69267	71	11	carboxamide	carboxamide	NOUN
bjp-69267	71	12	the	the	DET
bjp-69267	71	13	titled	title	VERB
bjp-69267	71	14	compound	compound	NOUN
bjp-69267	71	15	was	be	AUX
bjp-69267	71	16	obtained	obtain	VERB
bjp-69267	71	17	in	in	ADP
bjp-69267	71	18	good	good	ADJ
bjp-69267	71	19	yield	yield	NOUN
bjp-69267	71	20	(	(	PUNCT
bjp-69267	71	21	1.9	1.9	NUM
bjp-69267	71	22	g	g	NOUN
bjp-69267	71	23	,	,	PUNCT
bjp-69267	71	24	77	77	NUM
bjp-69267	71	25	%	%	NOUN
bjp-69267	71	26	)	)	PUNCT
bjp-69267	71	27	.	.	PUNCT
bjp-69267	72	1	the	the	DET
bjp-69267	72	2	melting	melting	NOUN
bjp-69267	72	3	point	point	NOUN
bjp-69267	72	4	was	be	AUX
bjp-69267	72	5	184	184	NUM
bjp-69267	72	6	-	-	SYM
bjp-69267	72	7	186	186	NUM
bjp-69267	72	8	°	°	SYM
bjp-69267	72	9	c	c	NOUN
bjp-69267	72	10	.	.	PUNCT
bjp-69267	73	1	characterization	characterization	NOUN
bjp-69267	73	2	the	the	DET
bjp-69267	73	3	resulting	result	VERB
bjp-69267	73	4	1h	1h	NUM
bjp-69267	73	5	nmr	nmr	NOUN
bjp-69267	73	6	spectrum	spectrum	NOUN
bjp-69267	73	7	exhibited	exhibit	VERB
bjp-69267	73	8	a	a	DET
bjp-69267	73	9	singlet	singlet	ADJ
bjp-69267	73	10	signal	signal	NOUN
bjp-69267	73	11	at	at	ADP
bjp-69267	73	12	the	the	DET
bjp-69267	73	13	chemical	chemical	NOUN
bjp-69267	73	14	shift	shift	NOUN
bjp-69267	74	1	δ	δ	PROPN
bjp-69267	74	2	2.8	2.8	NUM
bjp-69267	74	3	ppm	ppm	NOUN
bjp-69267	74	4	corresponding	correspond	VERB
bjp-69267	74	5	to	to	ADP
bjp-69267	74	6	h22	h22	PROPN
bjp-69267	74	7	and	and	CCONJ
bjp-69267	74	8	h23	h23	NOUN
bjp-69267	74	9	protons	proton	NOUN
bjp-69267	74	10	of	of	ADP
bjp-69267	74	11	the	the	DET
bjp-69267	74	12	dimethylamino	dimethylamino	PROPN
bjp-69267	74	13	group	group	NOUN
bjp-69267	74	14	(	(	PUNCT
bjp-69267	74	15	figure	figure	NOUN
bjp-69267	74	16	1	1	NUM
bjp-69267	74	17	)	)	PUNCT
bjp-69267	74	18	.	.	PUNCT
bjp-69267	75	1	the	the	DET
bjp-69267	75	2	spectrum	spectrum	NOUN
bjp-69267	75	3	confirmed	confirm	VERB
bjp-69267	75	4	the	the	DET
bjp-69267	75	5	pyrazoline	pyrazoline	NOUN
bjp-69267	75	6	ring	ring	NOUN
bjp-69267	75	7	formation	formation	NOUN
bjp-69267	75	8	due	due	ADP
bjp-69267	75	9	to	to	ADP
bjp-69267	75	10	the	the	DET
bjp-69267	75	11	appearance	appearance	NOUN
bjp-69267	75	12	of	of	ADP
bjp-69267	75	13	three	three	NUM
bjp-69267	75	14	doublet	doublet	NOUN
bjp-69267	75	15	of	of	ADP
bjp-69267	75	16	doublet	doublet	NOUN
bjp-69267	75	17	at	at	ADP
bjp-69267	75	18	the	the	DET
bjp-69267	75	19	chemical	chemical	ADJ
bjp-69267	75	20	shifts	shift	NOUN
bjp-69267	75	21	δ	δ	PROPN
bjp-69267	75	22	3.0	3.0	NUM
bjp-69267	75	23	-	-	SYM
bjp-69267	75	24	3.07	3.07	NUM
bjp-69267	75	25	ppm	ppm	NOUN
bjp-69267	75	26	(	(	PUNCT
bjp-69267	75	27	dd	dd	NOUN
bjp-69267	75	28	,	,	PUNCT
bjp-69267	75	29	j	j	NOUN
bjp-69267	75	30	=	=	PROPN
bjp-69267	75	31	17.7	17.7	NUM
bjp-69267	75	32	,	,	PUNCT
bjp-69267	75	33	4.9	4.9	NUM
bjp-69267	75	34	hz	hz	NOUN
bjp-69267	75	35	,	,	PUNCT
bjp-69267	75	36	1h	1h	NUM
bjp-69267	75	37	)	)	PUNCT
bjp-69267	75	38	,	,	PUNCT
bjp-69267	75	39	δ	δ	PROPN
bjp-69267	75	40	3.7	3.7	NUM
bjp-69267	75	41	-	-	SYM
bjp-69267	75	42	3.8	3.8	NUM
bjp-69267	75	43	ppm	ppm	NOUN
bjp-69267	75	44	(	(	PUNCT
bjp-69267	75	45	dd	dd	NOUN
bjp-69267	75	46	,	,	PUNCT
bjp-69267	75	47	j	j	NOUN
bjp-69267	75	48	=	=	PROPN
bjp-69267	75	49	17.7	17.7	NUM
bjp-69267	75	50	,	,	PUNCT
bjp-69267	75	51	11.9	11.9	NUM
bjp-69267	75	52	hz	hz	NOUN
bjp-69267	75	53	,	,	PUNCT
bjp-69267	75	54	1h	1h	NUM
bjp-69267	75	55	)	)	PUNCT
bjp-69267	75	56	and	and	CCONJ
bjp-69267	75	57	δ	δ	PROPN
bjp-69267	75	58	5.2	5.2	NUM
bjp-69267	75	59	-	-	SYM
bjp-69267	75	60	5.3	5.3	NUM
bjp-69267	75	61	ppm	ppm	NOUN
bjp-69267	75	62	(	(	PUNCT
bjp-69267	75	63	dd	dd	NOUN
bjp-69267	75	64	,	,	PUNCT
bjp-69267	75	65	j	j	NOUN
bjp-69267	75	66	=	=	NUM
bjp-69267	75	67	11.9	11.9	NUM
bjp-69267	75	68	,	,	PUNCT
bjp-69267	75	69	4.9	4.9	NUM
bjp-69267	75	70	hz	hz	NOUN
bjp-69267	75	71	,	,	PUNCT
bjp-69267	75	72	1h	1h	NUM
bjp-69267	75	73	)	)	PUNCT
bjp-69267	75	74	,	,	PUNCT
bjp-69267	75	75	respectively	respectively	ADV
bjp-69267	75	76	referred	refer	VERB
bjp-69267	75	77	for	for	ADP
bjp-69267	75	78	h1	h1	NOUN
bjp-69267	75	79	and	and	CCONJ
bjp-69267	75	80	h3	h3	NOUN
bjp-69267	75	81	.	.	PUNCT
bjp-69267	76	1	the	the	DET
bjp-69267	76	2	singlet	singlet	ADJ
bjp-69267	76	3	signal	signal	NOUN
bjp-69267	76	4	resonated	resonate	VERB
bjp-69267	76	5	at	at	ADP
bjp-69267	76	6	δ	δ	PROPN
bjp-69267	76	7	6.31	6.31	NUM
bjp-69267	76	8	ppm	ppm	NOUN
bjp-69267	76	9	assigned	assign	VERB
bjp-69267	76	10	to	to	ADP
bjp-69267	76	11	h20	h20	PROPN
bjp-69267	76	12	of	of	ADP
bjp-69267	76	13	the	the	DET
bjp-69267	76	14	carboxamide	carboxamide	NOUN
bjp-69267	76	15	entity	entity	NOUN
bjp-69267	76	16	and	and	CCONJ
bjp-69267	76	17	the	the	DET
bjp-69267	76	18	multiplet	multiplet	NOUN
bjp-69267	76	19	signals	signal	NOUN
bjp-69267	76	20	observed	observe	VERB
bjp-69267	76	21	in	in	ADP
bjp-69267	76	22	different	different	ADJ
bjp-69267	76	23	integrals	integral	NOUN
bjp-69267	76	24	ratios	ratio	NOUN
bjp-69267	76	25	between	between	ADP
bjp-69267	76	26	δ	δ	PROPN
bjp-69267	76	27	6.6	6.6	NUM
bjp-69267	76	28	and	and	CCONJ
bjp-69267	76	29	δ	δ	PROPN
bjp-69267	76	30	7.8	7.8	NUM
bjp-69267	76	31	ppm	ppm	NOUN
bjp-69267	76	32	were	be	AUX
bjp-69267	76	33	attributed	attribute	VERB
bjp-69267	76	34	to	to	ADP
bjp-69267	76	35	aromatic	aromatic	ADJ
bjp-69267	76	36	protons	proton	NOUN
bjp-69267	76	37	.	.	PUNCT
bjp-69267	77	1	the	the	DET
bjp-69267	77	2	dept-135	dept-135	PROPN
bjp-69267	77	3	spectrum	spectrum	NOUN
bjp-69267	77	4	showed	show	VERB
bjp-69267	77	5	a	a	DET
bjp-69267	77	6	signal	signal	NOUN
bjp-69267	77	7	at	at	ADP
bjp-69267	77	8	the	the	DET
bjp-69267	77	9	chemical	chemical	ADJ
bjp-69267	77	10	shifts	shift	NOUN
bjp-69267	77	11	δ	δ	PROPN
bjp-69267	77	12	40.2	40.2	NUM
bjp-69267	77	13	-	-	SYM
bjp-69267	77	14	41.1	41.1	NUM
bjp-69267	77	15	ppm	ppm	NOUN
bjp-69267	77	16	referred	refer	VERB
bjp-69267	77	17	to	to	ADP
bjp-69267	77	18	c22	c22	PROPN
bjp-69267	77	19	and	and	CCONJ
bjp-69267	77	20	c23	c23	PROPN
bjp-69267	77	21	carbons	carbon	NOUN
bjp-69267	77	22	of	of	ADP
bjp-69267	77	23	the	the	DET
bjp-69267	77	24	dimethylamino	dimethylamino	PROPN
bjp-69267	77	25	group	group	NOUN
bjp-69267	77	26	(	(	PUNCT
bjp-69267	77	27	figure	figure	NOUN
bjp-69267	77	28	2	2	NUM
bjp-69267	77	29	)	)	PUNCT
bjp-69267	77	30	.	.	PUNCT
bjp-69267	78	1	the	the	DET
bjp-69267	78	2	spectrum	spectrum	NOUN
bjp-69267	78	3	confirmed	confirm	VERB
bjp-69267	78	4	the	the	DET
bjp-69267	78	5	successful	successful	ADJ
bjp-69267	78	6	cyclization	cyclization	NOUN
bjp-69267	78	7	of	of	ADP
bjp-69267	78	8	the	the	DET
bjp-69267	78	9	pyrazoline	pyrazoline	NOUN
bjp-69267	78	10	ring	ring	NOUN
bjp-69267	78	11	by	by	ADP
bjp-69267	78	12	the	the	DET
bjp-69267	78	13	appearance	appearance	NOUN
bjp-69267	78	14	of	of	ADP
bjp-69267	78	15	a	a	DET
bjp-69267	78	16	negative	negative	ADJ
bjp-69267	78	17	peak	peak	NOUN
bjp-69267	78	18	at	at	ADP
bjp-69267	78	19	δ	δ	PROPN
bjp-69267	78	20	67.4	67.4	NUM
bjp-69267	78	21	-	-	SYM
bjp-69267	78	22	64.1	64.1	NUM
bjp-69267	78	23	ppm	ppm	NOUN
bjp-69267	78	24	and	and	CCONJ
bjp-69267	78	25	a	a	DET
bjp-69267	78	26	positive	positive	ADJ
bjp-69267	78	27	peak	peak	NOUN
bjp-69267	78	28	at	at	ADP
bjp-69267	78	29	δ	δ	PROPN
bjp-69267	78	30	59.7	59.7	NUM
bjp-69267	78	31	ppm	ppm	NOUN
bjp-69267	78	32	,	,	PUNCT
bjp-69267	78	33	respectively	respectively	ADV
bjp-69267	78	34	assigned	assign	VERB
bjp-69267	78	35	to	to	ADP
bjp-69267	78	36	c1	c1	PROPN
bjp-69267	78	37	and	and	CCONJ
bjp-69267	78	38	c2	c2	PROPN
bjp-69267	78	39	carbons	carbon	NOUN
bjp-69267	78	40	.	.	PUNCT
bjp-69267	79	1	fourier	fourier	PROPN
bjp-69267	79	2	transform	transform	VERB
bjp-69267	79	3	infrared	infrared	ADJ
bjp-69267	79	4	spectroscopy	spectroscopy	NOUN
bjp-69267	79	5	(	(	PUNCT
bjp-69267	79	6	ftir	ftir	PROPN
bjp-69267	79	7	)	)	PUNCT
bjp-69267	79	8	of	of	ADP
bjp-69267	79	9	the	the	DET
bjp-69267	79	10	title	title	NOUN
bjp-69267	79	11	compound	compound	NOUN
bjp-69267	79	12	showed	show	VERB
bjp-69267	79	13	an	an	DET
bjp-69267	79	14	intense	intense	ADJ
bjp-69267	79	15	peak	peak	NOUN
bjp-69267	79	16	at	at	ADP
bjp-69267	79	17	1674	1674	NUM
bjp-69267	79	18	cm-1	cm-1	NOUN
bjp-69267	79	19	assigned	assign	VERB
bjp-69267	79	20	to	to	ADP
bjp-69267	79	21	the	the	DET
bjp-69267	79	22	c	c	PROPN
bjp-69267	79	23	=	=	NOUN
bjp-69267	79	24	o	o	NOUN
bjp-69267	79	25	band	band	NOUN
bjp-69267	79	26	and	and	CCONJ
bjp-69267	79	27	a	a	DET
bjp-69267	79	28	wide	wide	ADJ
bjp-69267	79	29	band	band	NOUN
bjp-69267	79	30	at	at	ADP
bjp-69267	79	31	3470	3470	NUM
bjp-69267	79	32	cm-1	cm-1	VERB
bjp-69267	79	33	referring	refer	VERB
bjp-69267	79	34	to	to	ADP
bjp-69267	79	35	the	the	DET
bjp-69267	79	36	n	n	CCONJ
bjp-69267	79	37	-	-	PUNCT
bjp-69267	79	38	h	h	NOUN
bjp-69267	79	39	band	band	NOUN
bjp-69267	79	40	of	of	ADP
bjp-69267	79	41	the	the	DET
bjp-69267	79	42	carboxamide	carboxamide	NOUN
bjp-69267	79	43	entity	entity	NOUN
bjp-69267	79	44	(	(	PUNCT
bjp-69267	79	45	figure	figure	NOUN
bjp-69267	79	46	3	3	NUM
bjp-69267	79	47	)	)	PUNCT
bjp-69267	79	48	.	.	PUNCT
bjp-69267	80	1	the	the	DET
bjp-69267	80	2	c	c	NOUN
bjp-69267	80	3	-	-	PUNCT
bjp-69267	80	4	h	h	NOUN
bjp-69267	80	5	band	band	NOUN
bjp-69267	80	6	of	of	ADP
bjp-69267	80	7	phenyl	phenyl	NOUN
bjp-69267	80	8	ring	ring	NOUN
bjp-69267	80	9	hybridized	hybridize	VERB
bjp-69267	80	10	sp3	sp3	NOUN
bjp-69267	80	11	was	be	AUX
bjp-69267	80	12	observed	observe	VERB
bjp-69267	80	13	at	at	ADP
bjp-69267	80	14	2910	2910	NUM
bjp-69267	80	15	cm-1	cm-1	X
bjp-69267	80	16	and	and	CCONJ
bjp-69267	80	17	that	that	DET
bjp-69267	80	18	pyrazoline	pyrazoline	NOUN
bjp-69267	80	19	ring	ring	NOUN
bjp-69267	80	20	hybridized	hybridize	VERB
bjp-69267	80	21	sp2	sp2	NOUN
bjp-69267	80	22	appeared	appear	VERB
bjp-69267	80	23	at	at	ADP
bjp-69267	80	24	2805	2805	NUM
bjp-69267	80	25	cm-1	cm-1	NOUN
bjp-69267	80	26	.	.	PUNCT
bjp-69267	81	1	154	154	NUM
bjp-69267	81	2	bangladesh	bangladesh	PROPN
bjp-69267	81	3	j	j	PROPN
bjp-69267	81	4	pharmacol	pharmacol	PROPN
bjp-69267	81	5	2023	2023	NUM
bjp-69267	81	6	;	;	PUNCT
bjp-69267	81	7	18	18	NUM
bjp-69267	81	8	:	:	SYM
bjp-69267	81	9	152	152	NUM
bjp-69267	81	10	-	-	SYM
bjp-69267	81	11	161	161	NUM
bjp-69267	81	12	http://www.rcsb.org	http://www.rcsb.org	ADJ
bjp-69267	81	13	http://imods.chaconlab.org	http://imods.chaconlab.org	VERB
bjp-69267	81	14	antimicrobial	antimicrobial	ADJ
bjp-69267	81	15	activity	activity	NOUN
bjp-69267	81	16	the	the	DET
bjp-69267	81	17	results	result	NOUN
bjp-69267	81	18	showed	show	VERB
bjp-69267	81	19	varying	vary	VERB
bjp-69267	81	20	degrees	degree	NOUN
bjp-69267	81	21	of	of	ADP
bjp-69267	81	22	inhibition	inhibition	NOUN
bjp-69267	81	23	against	against	ADP
bjp-69267	81	24	the	the	DET
bjp-69267	81	25	tested	test	VERB
bjp-69267	81	26	microorganisms	microorganism	NOUN
bjp-69267	81	27	at	at	ADP
bjp-69267	81	28	different	different	ADJ
bjp-69267	81	29	concentrations	concentration	NOUN
bjp-69267	81	30	of	of	ADP
bjp-69267	81	31	pyrazoline	pyrazoline	NOUN
bjp-69267	81	32	carboxamide	carboxamide	NOUN
bjp-69267	81	33	(	(	PUNCT
bjp-69267	81	34	table	table	NOUN
bjp-69267	81	35	i	i	NOUN
bjp-69267	81	36	)	)	PUNCT
bjp-69267	81	37	.	.	PUNCT
bjp-69267	82	1	e.	e.	PROPN
bjp-69267	82	2	coli	coli	PROPN
bjp-69267	82	3	showed	show	VERB
bjp-69267	82	4	moderate	moderate	ADJ
bjp-69267	82	5	sensitivity	sensitivity	NOUN
bjp-69267	82	6	towards	towards	ADP
bjp-69267	82	7	the	the	DET
bjp-69267	82	8	synthesized	synthesize	VERB
bjp-69267	82	9	compound	compound	NOUN
bjp-69267	82	10	,	,	PUNCT
bjp-69267	82	11	with	with	ADP
bjp-69267	82	12	zones	zone	NOUN
bjp-69267	82	13	of	of	ADP
bjp-69267	82	14	inhibition	inhibition	NOUN
bjp-69267	82	15	ranging	range	VERB
bjp-69267	82	16	from	from	ADP
bjp-69267	82	17	11.3	11.3	NUM
bjp-69267	82	18	±	±	NUM
bjp-69267	82	19	0.1	0.1	NUM
bjp-69267	82	20	mm	mm	NOUN
bjp-69267	82	21	to	to	ADP
bjp-69267	82	22	13.8	13.8	NUM
bjp-69267	82	23	±	±	NUM
bjp-69267	82	24	0.8	0.8	NUM
bjp-69267	82	25	mm	mm	NOUN
bjp-69267	82	26	for	for	ADP
bjp-69267	82	27	the	the	DET
bjp-69267	82	28	concentrations	concentration	NOUN
bjp-69267	82	29	tested	test	VERB
bjp-69267	82	30	.	.	PUNCT
bjp-69267	83	1	s.	s.	PROPN
bjp-69267	83	2	aureus	aureus	PROPN
bjp-69267	83	3	showed	show	VERB
bjp-69267	83	4	a	a	DET
bjp-69267	83	5	similar	similar	ADJ
bjp-69267	83	6	response	response	NOUN
bjp-69267	83	7	,	,	PUNCT
bjp-69267	83	8	with	with	ADP
bjp-69267	83	9	zones	zone	NOUN
bjp-69267	83	10	of	of	ADP
bjp-69267	83	11	inhibition	inhibition	NOUN
bjp-69267	83	12	ranging	range	VERB
bjp-69267	83	13	from	from	ADP
bjp-69267	83	14	10.9	10.9	NUM
bjp-69267	83	15	±	±	NUM
bjp-69267	83	16	0.7	0.7	NUM
bjp-69267	83	17	mm	mm	NOUN
bjp-69267	83	18	to	to	ADP
bjp-69267	83	19	14.1	14.1	NUM
bjp-69267	83	20	±	±	NUM
bjp-69267	83	21	0.2	0.2	NUM
bjp-69267	83	22	mm	mm	NOUN
bjp-69267	83	23	.	.	PUNCT
bjp-69267	84	1	notably	notably	ADV
bjp-69267	84	2	,	,	PUNCT
bjp-69267	84	3	l.	l.	PROPN
bjp-69267	84	4	monocytogenes	monocytogene	NOUN
bjp-69267	84	5	showed	show	VERB
bjp-69267	84	6	greater	great	ADJ
bjp-69267	84	7	sensitivity	sensitivity	NOUN
bjp-69267	84	8	to	to	PART
bjp-69267	84	9	pyrazoline	pyrazoline	NOUN
bjp-69267	84	10	carboxamide	carboxamide	VERB
bjp-69267	84	11	,	,	PUNCT
bjp-69267	84	12	with	with	ADP
bjp-69267	84	13	zones	zone	NOUN
bjp-69267	84	14	of	of	ADP
bjp-69267	84	15	inhibition	inhibition	NOUN
bjp-69267	84	16	ranging	range	VERB
bjp-69267	84	17	from	from	ADP
bjp-69267	84	18	14.2	14.2	NUM
bjp-69267	84	19	±	±	NUM
bjp-69267	84	20	0.0	0.0	NUM
bjp-69267	84	21	mm	mm	NOUN
bjp-69267	84	22	to	to	ADP
bjp-69267	84	23	16.8	16.8	NUM
bjp-69267	84	24	±	±	NUM
bjp-69267	84	25	1.3	1.3	NUM
bjp-69267	84	26	mm	mm	NOUN
bjp-69267	84	27	.	.	PUNCT
bjp-69267	85	1	whereas	whereas	SCONJ
bjp-69267	85	2	,	,	PUNCT
bjp-69267	85	3	p.	p.	NOUN
bjp-69267	85	4	aeruginosa	aeruginosa	PROPN
bjp-69267	85	5	showed	show	VERB
bjp-69267	85	6	a	a	DET
bjp-69267	85	7	moderate	moderate	ADJ
bjp-69267	85	8	response	response	NOUN
bjp-69267	85	9	,	,	PUNCT
bjp-69267	85	10	with	with	ADP
bjp-69267	85	11	zones	zone	NOUN
bjp-69267	85	12	of	of	ADP
bjp-69267	85	13	inhibition	inhibition	NOUN
bjp-69267	85	14	ranging	range	VERB
bjp-69267	85	15	from	from	ADP
bjp-69267	85	16	11.2	11.2	NUM
bjp-69267	85	17	±	±	NUM
bjp-69267	85	18	0.0	0.0	NUM
bjp-69267	85	19	mm	mm	NOUN
bjp-69267	85	20	to	to	ADP
bjp-69267	85	21	12.8	12.8	NUM
bjp-69267	85	22	±	±	NUM
bjp-69267	85	23	1.1	1.1	NUM
bjp-69267	85	24	mm	mm	NOUN
bjp-69267	85	25	.	.	PUNCT
bjp-69267	86	1	in	in	ADP
bjp-69267	86	2	contrast	contrast	NOUN
bjp-69267	86	3	,	,	PUNCT
bjp-69267	86	4	c.	c.	NOUN
bjp-69267	86	5	albicans	albican	NOUN
bjp-69267	86	6	showed	show	VERB
bjp-69267	86	7	notable	notable	ADJ
bjp-69267	86	8	sensitivity	sensitivity	NOUN
bjp-69267	86	9	to	to	PART
bjp-69267	86	10	pyrazoline	pyrazoline	NOUN
bjp-69267	86	11	carboxamide	carboxamide	VERB
bjp-69267	86	12	,	,	PUNCT
bjp-69267	86	13	with	with	ADP
bjp-69267	86	14	zones	zone	NOUN
bjp-69267	86	15	of	of	ADP
bjp-69267	86	16	inhibition	inhibition	NOUN
bjp-69267	86	17	ranging	range	VERB
bjp-69267	86	18	from	from	ADP
bjp-69267	86	19	10.9	10.9	NUM
bjp-69267	86	20	±	±	NUM
bjp-69267	86	21	0.6	0.6	NUM
bjp-69267	86	22	mm	mm	NOUN
bjp-69267	86	23	to	to	ADP
bjp-69267	86	24	17.8	17.8	NUM
bjp-69267	86	25	±	±	NUM
bjp-69267	86	26	1.5	1.5	NUM
bjp-69267	86	27	mm	mm	NOUN
bjp-69267	86	28	.	.	PUNCT
bjp-69267	87	1	comparatively	comparatively	ADV
bjp-69267	87	2	,	,	PUNCT
bjp-69267	87	3	the	the	DET
bjp-69267	87	4	selected	select	VERB
bjp-69267	87	5	antibiotics	antibiotic	NOUN
bjp-69267	87	6	showed	show	VERB
bjp-69267	87	7	variable	variable	ADJ
bjp-69267	87	8	levels	level	NOUN
bjp-69267	87	9	of	of	ADP
bjp-69267	87	10	inhibition	inhibition	NOUN
bjp-69267	87	11	.	.	PUNCT
bjp-69267	88	1	gentamicin	gentamicin	PROPN
bjp-69267	88	2	showed	show	VERB
bjp-69267	88	3	significant	significant	ADJ
bjp-69267	88	4	inhibition	inhibition	NOUN
bjp-69267	88	5	against	against	ADP
bjp-69267	88	6	e.	e.	PROPN
bjp-69267	88	7	coli	coli	PROPN
bjp-69267	88	8	(	(	PUNCT
bjp-69267	88	9	31.8	31.8	NUM
bjp-69267	88	10	±	±	NUM
bjp-69267	88	11	0.2	0.2	NUM
bjp-69267	88	12	mm	mm	NOUN
bjp-69267	88	13	)	)	PUNCT
bjp-69267	88	14	and	and	CCONJ
bjp-69267	88	15	s.	s.	PROPN
bjp-69267	88	16	aureus	aureus	PROPN
bjp-69267	88	17	(	(	PUNCT
bjp-69267	88	18	18.9	18.9	NUM
bjp-69267	88	19	±	±	NUM
bjp-69267	88	20	0.4	0.4	NUM
bjp-69267	88	21	mm	mm	NOUN
bjp-69267	88	22	)	)	PUNCT
bjp-69267	88	23	.	.	PUNCT
bjp-69267	89	1	piephemidic	piephemidic	ADJ
bjp-69267	89	2	acid	acid	PROPN
bjp-69267	89	3	showed	show	VERB
bjp-69267	89	4	moderate	moderate	ADJ
bjp-69267	89	5	inhibition	inhibition	NOUN
bjp-69267	89	6	against	against	ADP
bjp-69267	89	7	s.	s.	PROPN
bjp-69267	89	8	aureus	aureus	PROPN
bjp-69267	89	9	(	(	PUNCT
bjp-69267	89	10	14.6	14.6	NUM
bjp-69267	89	11	±	±	NUM
bjp-69267	89	12	0.3	0.3	NUM
bjp-69267	89	13	mm	mm	NOUN
bjp-69267	89	14	)	)	PUNCT
bjp-69267	89	15	,	,	PUNCT
bjp-69267	89	16	while	while	SCONJ
bjp-69267	89	17	cefazolin	cefazolin	PROPN
bjp-69267	89	18	showed	show	VERB
bjp-69267	89	19	moderate	moderate	ADJ
bjp-69267	89	20	inhibition	inhibition	NOUN
bjp-69267	89	21	against	against	ADP
bjp-69267	89	22	s.	s.	PROPN
bjp-69267	89	23	aureus	aureus	PROPN
bjp-69267	89	24	(	(	PUNCT
bjp-69267	89	25	28.9	28.9	NUM
bjp-69267	89	26	±	±	NUM
bjp-69267	89	27	0.8	0.8	NUM
bjp-69267	89	28	mm	mm	NOUN
bjp-69267	89	29	)	)	PUNCT
bjp-69267	89	30	and	and	CCONJ
bjp-69267	89	31	p.	p.	NOUN
bjp-69267	89	32	aeruginosa	aeruginosa	PROPN
bjp-69267	89	33	(	(	PUNCT
bjp-69267	89	34	26.2	26.2	NUM
bjp-69267	89	35	±	±	NUM
bjp-69267	89	36	1.6	1.6	NUM
bjp-69267	89	37	mm	mm	NOUN
bjp-69267	89	38	)	)	PUNCT
bjp-69267	89	39	.	.	PUNCT
bjp-69267	90	1	colistin	colistin	PROPN
bjp-69267	90	2	showed	show	VERB
bjp-69267	90	3	limited	limited	ADJ
bjp-69267	90	4	efficacy	efficacy	NOUN
bjp-69267	90	5	,	,	PUNCT
bjp-69267	90	6	with	with	ADP
bjp-69267	90	7	a	a	DET
bjp-69267	90	8	zone	zone	NOUN
bjp-69267	90	9	of	of	ADP
bjp-69267	90	10	inhibition	inhibition	NOUN
bjp-69267	90	11	of	of	ADP
bjp-69267	90	12	13.2	13.2	NUM
bjp-69267	90	13	±	±	NUM
bjp-69267	90	14	0.1	0.1	NUM
bjp-69267	90	15	mm	mm	NOUN
bjp-69267	90	16	against	against	ADP
bjp-69267	90	17	p.	p.	PROPN
bjp-69267	90	18	aeruginosa	aeruginosa	PROPN
bjp-69267	90	19	.	.	PUNCT
bjp-69267	91	1	drug	drug	NOUN
bjp-69267	91	2	-	-	PUNCT
bjp-69267	91	3	likeness	likeness	NOUN
bjp-69267	91	4	and	and	CCONJ
bjp-69267	91	5	toxicity	toxicity	NOUN
bjp-69267	91	6	predictions	prediction	NOUN
bjp-69267	91	7	the	the	DET
bjp-69267	91	8	synthesized	synthesize	VERB
bjp-69267	91	9	novel	novel	ADJ
bjp-69267	91	10	pyrazoline	pyrazoline	NOUN
bjp-69267	91	11	carboxamide	carboxamide	NOUN
bjp-69267	91	12	compound	compound	PROPN
bjp-69267	91	13	exhibited	exhibit	VERB
bjp-69267	91	14	a	a	DET
bjp-69267	91	15	promising	promising	ADJ
bjp-69267	91	16	profile	profile	NOUN
bjp-69267	91	17	based	base	VERB
bjp-69267	91	18	on	on	ADP
bjp-69267	91	19	the	the	DET
bjp-69267	91	20	comprehensive	comprehensive	ADJ
bjp-69267	91	21	data	datum	NOUN
bjp-69267	91	22	analysis	analysis	NOUN
bjp-69267	91	23	provided	provide	VERB
bjp-69267	91	24	by	by	ADP
bjp-69267	91	25	the	the	DET
bjp-69267	91	26	swissfigure	swissfigure	NOUN
bjp-69267	91	27	1	1	NUM
bjp-69267	91	28	:	:	SYM
bjp-69267	91	29	1h	1h	NUM
bjp-69267	91	30	nmr	nmr	NOUN
bjp-69267	91	31	spectrum	spectrum	NOUN
bjp-69267	91	32	of	of	ADP
bjp-69267	91	33	the	the	DET
bjp-69267	91	34	pyrazoline	pyrazoline	NOUN
bjp-69267	91	35	carboxamide	carboxamide	NOUN
bjp-69267	91	36	compound	compound	PROPN
bjp-69267	91	37	bangladesh	bangladesh	PROPN
bjp-69267	91	38	j	j	PROPN
bjp-69267	91	39	pharmacol	pharmacol	PROPN
bjp-69267	91	40	2023	2023	NUM
bjp-69267	91	41	;	;	PUNCT
bjp-69267	91	42	18	18	NUM
bjp-69267	91	43	:	:	SYM
bjp-69267	91	44	152	152	NUM
bjp-69267	91	45	-	-	SYM
bjp-69267	91	46	161	161	NUM
bjp-69267	91	47	155	155	NUM
bjp-69267	91	48	adme	adme	NOUN
bjp-69267	91	49	platform	platform	NOUN
bjp-69267	91	50	(	(	PUNCT
bjp-69267	91	51	supplementary	supplementary	ADJ
bjp-69267	91	52	table	table	NOUN
bjp-69267	91	53	i	i	PROPN
bjp-69267	91	54	)	)	PUNCT
bjp-69267	91	55	.	.	PUNCT
bjp-69267	92	1	its	its	PRON
bjp-69267	92	2	physicochemical	physicochemical	ADJ
bjp-69267	92	3	attributes	attribute	NOUN
bjp-69267	92	4	,	,	PUNCT
bjp-69267	92	5	including	include	VERB
bjp-69267	92	6	molecular	molecular	ADJ
bjp-69267	92	7	weight	weight	NOUN
bjp-69267	92	8	,	,	PUNCT
bjp-69267	92	9	composition	composition	NOUN
bjp-69267	92	10	,	,	PUNCT
bjp-69267	92	11	and	and	CCONJ
bjp-69267	92	12	aromaticity	aromaticity	NOUN
bjp-69267	92	13	,	,	PUNCT
bjp-69267	92	14	position	position	VERB
bjp-69267	92	15	it	it	PRON
bjp-69267	92	16	within	within	ADP
bjp-69267	92	17	a	a	DET
bjp-69267	92	18	molecular	molecular	ADJ
bjp-69267	92	19	framework	framework	NOUN
bjp-69267	92	20	that	that	PRON
bjp-69267	92	21	could	could	AUX
bjp-69267	92	22	be	be	AUX
bjp-69267	92	23	favorable	favorable	ADJ
bjp-69267	92	24	for	for	ADP
bjp-69267	92	25	drug	drug	NOUN
bjp-69267	92	26	development	development	NOUN
bjp-69267	92	27	.	.	PUNCT
bjp-69267	93	1	the	the	DET
bjp-69267	93	2	relatively	relatively	ADV
bjp-69267	93	3	low	low	ADJ
bjp-69267	93	4	fraction	fraction	NOUN
bjp-69267	93	5	of	of	ADP
bjp-69267	93	6	sp3	sp3	ADJ
bjp-69267	93	7	hybriddization	hybriddization	NOUN
bjp-69267	93	8	(	(	PUNCT
bjp-69267	93	9	csp3	csp3	NOUN
bjp-69267	93	10	)	)	PUNCT
bjp-69267	93	11	might	might	AUX
bjp-69267	93	12	suggest	suggest	VERB
bjp-69267	93	13	a	a	DET
bjp-69267	93	14	balance	balance	NOUN
bjp-69267	93	15	between	between	ADP
bjp-69267	93	16	aromatic	aromatic	ADJ
bjp-69267	93	17	and	and	CCONJ
bjp-69267	93	18	aliphatic	aliphatic	ADJ
bjp-69267	93	19	components	component	NOUN
bjp-69267	93	20	,	,	PUNCT
bjp-69267	93	21	potentially	potentially	ADV
bjp-69267	93	22	influencing	influence	VERB
bjp-69267	93	23	its	its	PRON
bjp-69267	93	24	interactions	interaction	NOUN
bjp-69267	93	25	and	and	CCONJ
bjp-69267	93	26	reactivity	reactivity	NOUN
bjp-69267	93	27	.	.	PUNCT
bjp-69267	94	1	the	the	DET
bjp-69267	94	2	compound	compound	NOUN
bjp-69267	94	3	's	's	PART
bjp-69267	94	4	lipophilicity	lipophilicity	NOUN
bjp-69267	94	5	,	,	PUNCT
bjp-69267	94	6	as	as	SCONJ
bjp-69267	94	7	indicated	indicate	VERB
bjp-69267	94	8	by	by	ADP
bjp-69267	94	9	various	various	ADJ
bjp-69267	94	10	log	log	NOUN
bjp-69267	94	11	po	po	PROPN
bjp-69267	94	12	/	/	SYM
bjp-69267	94	13	w	w	NOUN
bjp-69267	94	14	values	value	NOUN
bjp-69267	94	15	,	,	PUNCT
bjp-69267	94	16	suggests	suggest	VERB
bjp-69267	94	17	a	a	DET
bjp-69267	94	18	moderate	moderate	ADJ
bjp-69267	94	19	affinity	affinity	NOUN
bjp-69267	94	20	for	for	ADP
bjp-69267	94	21	both	both	CCONJ
bjp-69267	94	22	aqueous	aqueous	ADJ
bjp-69267	94	23	and	and	CCONJ
bjp-69267	94	24	lipid	lipid	NOUN
bjp-69267	94	25	environments	environment	NOUN
bjp-69267	94	26	.	.	PUNCT
bjp-69267	95	1	this	this	PRON
bjp-69267	95	2	could	could	AUX
bjp-69267	95	3	have	have	VERB
bjp-69267	95	4	implications	implication	NOUN
bjp-69267	95	5	for	for	ADP
bjp-69267	95	6	its	its	PRON
bjp-69267	95	7	distribution	distribution	NOUN
bjp-69267	95	8	within	within	ADP
bjp-69267	95	9	the	the	DET
bjp-69267	95	10	body	body	NOUN
bjp-69267	95	11	and	and	CCONJ
bjp-69267	95	12	its	its	PRON
bjp-69267	95	13	potential	potential	NOUN
bjp-69267	95	14	to	to	PART
bjp-69267	95	15	permeate	permeate	VERB
bjp-69267	95	16	biological	biological	ADJ
bjp-69267	95	17	membranes	membrane	NOUN
bjp-69267	95	18	.	.	PUNCT
bjp-69267	96	1	furthermore	furthermore	ADV
bjp-69267	96	2	,	,	PUNCT
bjp-69267	96	3	the	the	DET
bjp-69267	96	4	compound	compound	NOUN
bjp-69267	96	5	's	's	PART
bjp-69267	96	6	solubility	solubility	NOUN
bjp-69267	96	7	characteristics	characteristic	NOUN
bjp-69267	96	8	,	,	PUNCT
bjp-69267	96	9	spanning	span	VERB
bjp-69267	96	10	a	a	DET
bjp-69267	96	11	range	range	NOUN
bjp-69267	96	12	of	of	ADP
bjp-69267	96	13	methods	method	NOUN
bjp-69267	96	14	,	,	PUNCT
bjp-69267	96	15	underline	underline	VERB
bjp-69267	96	16	its	its	PRON
bjp-69267	96	17	ability	ability	NOUN
bjp-69267	96	18	to	to	PART
bjp-69267	96	19	dissolve	dissolve	VERB
bjp-69267	96	20	in	in	ADP
bjp-69267	96	21	aqueous	aqueous	ADJ
bjp-69267	96	22	solutions	solution	NOUN
bjp-69267	96	23	,	,	PUNCT
bjp-69267	96	24	which	which	PRON
bjp-69267	96	25	is	be	AUX
bjp-69267	96	26	essential	essential	ADJ
bjp-69267	96	27	for	for	ADP
bjp-69267	96	28	effective	effective	ADJ
bjp-69267	96	29	delivery	delivery	NOUN
bjp-69267	96	30	and	and	CCONJ
bjp-69267	96	31	absorption	absorption	NOUN
bjp-69267	96	32	.	.	PUNCT
bjp-69267	97	1	in	in	ADP
bjp-69267	97	2	terms	term	NOUN
bjp-69267	97	3	of	of	ADP
bjp-69267	97	4	pharmacokinetics	pharmacokinetic	NOUN
bjp-69267	97	5	,	,	PUNCT
bjp-69267	97	6	the	the	DET
bjp-69267	97	7	compound	compound	NOUN
bjp-69267	97	8	's	's	PART
bjp-69267	97	9	high	high	ADJ
bjp-69267	97	10	gastrointestinal	gastrointestinal	ADJ
bjp-69267	97	11	absorption	absorption	NOUN
bjp-69267	97	12	and	and	CCONJ
bjp-69267	97	13	bloodbrain	bloodbrain	NOUN
bjp-69267	97	14	barrier	barrier	NOUN
bjp-69267	97	15	permeation	permeation	NOUN
bjp-69267	97	16	potential	potential	ADJ
bjp-69267	97	17	hint	hint	NOUN
bjp-69267	97	18	at	at	ADP
bjp-69267	97	19	its	its	PRON
bjp-69267	97	20	ability	ability	NOUN
bjp-69267	97	21	to	to	PART
bjp-69267	97	22	effectively	effectively	ADV
bjp-69267	97	23	enter	enter	VERB
bjp-69267	97	24	the	the	DET
bjp-69267	97	25	systemic	systemic	ADJ
bjp-69267	97	26	circulation	circulation	NOUN
bjp-69267	97	27	and	and	CCONJ
bjp-69267	97	28	potentially	potentially	ADV
bjp-69267	97	29	target	target	VERB
bjp-69267	97	30	the	the	DET
bjp-69267	97	31	central	central	ADJ
bjp-69267	97	32	nervous	nervous	ADJ
bjp-69267	97	33	system	system	NOUN
bjp-69267	97	34	.	.	PUNCT
bjp-69267	98	1	the	the	DET
bjp-69267	98	2	nonsubstrate	nonsubstrate	NOUN
bjp-69267	98	3	status	status	NOUN
bjp-69267	98	4	for	for	ADP
bjp-69267	98	5	p	p	NOUN
bjp-69267	98	6	-	-	PUNCT
bjp-69267	98	7	glycoprotein	glycoprotein	NOUN
bjp-69267	98	8	is	be	AUX
bjp-69267	98	9	encouraging	encouraging	ADJ
bjp-69267	98	10	,	,	PUNCT
bjp-69267	98	11	as	as	SCONJ
bjp-69267	98	12	it	it	PRON
bjp-69267	98	13	suggests	suggest	VERB
bjp-69267	98	14	reduced	reduce	VERB
bjp-69267	98	15	susceptibility	susceptibility	NOUN
bjp-69267	98	16	to	to	PART
bjp-69267	98	17	efflux	efflux	VERB
bjp-69267	98	18	transporters	transporter	NOUN
bjp-69267	98	19	that	that	PRON
bjp-69267	98	20	can	can	AUX
bjp-69267	98	21	impede	impede	VERB
bjp-69267	98	22	drug	drug	NOUN
bjp-69267	98	23	absorption	absorption	NOUN
bjp-69267	98	24	(	(	PUNCT
bjp-69267	98	25	figure	figure	NOUN
bjp-69267	98	26	4	4	NUM
bjp-69267	98	27	)	)	PUNCT
bjp-69267	98	28	.	.	PUNCT
bjp-69267	99	1	however	however	ADV
bjp-69267	99	2	,	,	PUNCT
bjp-69267	99	3	its	its	PRON
bjp-69267	99	4	interactions	interaction	NOUN
bjp-69267	99	5	with	with	ADP
bjp-69267	99	6	various	various	ADJ
bjp-69267	99	7	cytochrome	cytochrome	ADJ
bjp-69267	99	8	p450	p450	NUM
bjp-69267	99	9	enzymes	enzyme	NOUN
bjp-69267	99	10	,	,	PUNCT
bjp-69267	99	11	including	include	VERB
bjp-69267	99	12	inhibition	inhibition	NOUN
bjp-69267	99	13	of	of	ADP
bjp-69267	99	14	cyp2c19	cyp2c19	NOUN
bjp-69267	99	15	and	and	CCONJ
bjp-69267	99	16	cyp2c9	cyp2c9	NOUN
bjp-69267	99	17	,	,	PUNCT
bjp-69267	99	18	warrant	warrant	VERB
bjp-69267	99	19	careful	careful	ADJ
bjp-69267	99	20	consideration	consideration	NOUN
bjp-69267	99	21	in	in	ADP
bjp-69267	99	22	terms	term	NOUN
bjp-69267	99	23	of	of	ADP
bjp-69267	99	24	drug	drug	NOUN
bjp-69267	99	25	interactions	interaction	NOUN
bjp-69267	99	26	and	and	CCONJ
bjp-69267	99	27	metabolic	metabolic	NOUN
bjp-69267	99	28	pathways	pathway	NOUN
bjp-69267	99	29	.	.	PUNCT
bjp-69267	100	1	the	the	DET
bjp-69267	100	2	compound	compound	NOUN
bjp-69267	100	3	's	's	PART
bjp-69267	100	4	favorable	favorable	ADJ
bjp-69267	100	5	drug	drug	NOUN
bjp-69267	100	6	figure	figure	NOUN
bjp-69267	100	7	2	2	NUM
bjp-69267	100	8	:	:	PUNCT
bjp-69267	100	9	dept-135	dept-135	PROPN
bjp-69267	100	10	spectrum	spectrum	VERB
bjp-69267	100	11	of	of	ADP
bjp-69267	100	12	the	the	DET
bjp-69267	100	13	pyrazoline	pyrazoline	NOUN
bjp-69267	100	14	carboxamide	carboxamide	NOUN
bjp-69267	100	15	compound	compound	NOUN
bjp-69267	100	16	figure	figure	NOUN
bjp-69267	100	17	3	3	NUM
bjp-69267	100	18	:	:	PUNCT
bjp-69267	100	19	ft	ft	PROPN
bjp-69267	100	20	-	-	PUNCT
bjp-69267	100	21	ir	ir	NOUN
bjp-69267	100	22	spectrum	spectrum	NOUN
bjp-69267	100	23	of	of	ADP
bjp-69267	100	24	the	the	DET
bjp-69267	100	25	pyrazoline	pyrazoline	NOUN
bjp-69267	100	26	carboxamide	carboxamide	NOUN
bjp-69267	100	27	compound	compound	VERB
bjp-69267	100	28	156	156	NUM
bjp-69267	100	29	bangladesh	bangladesh	PROPN
bjp-69267	100	30	j	j	PROPN
bjp-69267	100	31	pharmacol	pharmacol	PROPN
bjp-69267	100	32	2023	2023	NUM
bjp-69267	100	33	;	;	PUNCT
bjp-69267	100	34	18	18	NUM
bjp-69267	100	35	:	:	SYM
bjp-69267	100	36	152	152	NUM
bjp-69267	100	37	-	-	SYM
bjp-69267	100	38	161	161	NUM
bjp-69267	100	39	likeness	likeness	NOUN
bjp-69267	100	40	properties	property	NOUN
bjp-69267	100	41	,	,	PUNCT
bjp-69267	100	42	passing	pass	VERB
bjp-69267	100	43	multiple	multiple	ADJ
bjp-69267	100	44	filters	filter	NOUN
bjp-69267	100	45	including	include	VERB
bjp-69267	100	46	lipinski	lipinski	PROPN
bjp-69267	100	47	's	's	PART
bjp-69267	100	48	rule	rule	NOUN
bjp-69267	100	49	of	of	ADP
bjp-69267	100	50	five	five	NUM
bjp-69267	100	51	and	and	CCONJ
bjp-69267	100	52	others	other	NOUN
bjp-69267	100	53	,	,	PUNCT
bjp-69267	100	54	indicate	indicate	VERB
bjp-69267	100	55	its	its	PRON
bjp-69267	100	56	potential	potential	ADJ
bjp-69267	100	57	suitability	suitability	NOUN
bjp-69267	100	58	as	as	ADP
bjp-69267	100	59	a	a	DET
bjp-69267	100	60	drug	drug	NOUN
bjp-69267	100	61	candidate	candidate	NOUN
bjp-69267	100	62	.	.	PUNCT
bjp-69267	101	1	moreover	moreover	ADV
bjp-69267	101	2	,	,	PUNCT
bjp-69267	101	3	its	its	PRON
bjp-69267	101	4	bioavailability	bioavailability	NOUN
bjp-69267	101	5	score	score	NOUN
bjp-69267	101	6	falls	fall	VERB
bjp-69267	101	7	within	within	ADP
bjp-69267	101	8	a	a	DET
bjp-69267	101	9	moderate	moderate	ADJ
bjp-69267	101	10	range	range	NOUN
bjp-69267	101	11	,	,	PUNCT
bjp-69267	101	12	suggesting	suggest	VERB
bjp-69267	101	13	that	that	SCONJ
bjp-69267	101	14	its	its	PRON
bjp-69267	101	15	pharmacokinetic	pharmacokinetic	ADJ
bjp-69267	101	16	properties	property	NOUN
bjp-69267	101	17	align	align	VERB
bjp-69267	101	18	reasonably	reasonably	ADV
bjp-69267	101	19	well	well	ADV
bjp-69267	101	20	with	with	ADP
bjp-69267	101	21	expectations	expectation	NOUN
bjp-69267	101	22	for	for	ADP
bjp-69267	101	23	efficient	efficient	ADJ
bjp-69267	101	24	drug	drug	NOUN
bjp-69267	101	25	delivery	delivery	NOUN
bjp-69267	101	26	and	and	CCONJ
bjp-69267	101	27	exposure	exposure	NOUN
bjp-69267	101	28	.	.	PUNCT
bjp-69267	102	1	in	in	ADP
bjp-69267	102	2	the	the	DET
bjp-69267	102	3	realm	realm	NOUN
bjp-69267	102	4	of	of	ADP
bjp-69267	102	5	medicinal	medicinal	ADJ
bjp-69267	102	6	chemistry	chemistry	NOUN
bjp-69267	102	7	,	,	PUNCT
bjp-69267	102	8	the	the	DET
bjp-69267	102	9	presence	presence	NOUN
bjp-69267	102	10	of	of	ADP
bjp-69267	102	11	pains	pain	NOUN
bjp-69267	102	12	alerts	alert	NOUN
bjp-69267	102	13	raises	raise	VERB
bjp-69267	102	14	concerns	concern	NOUN
bjp-69267	102	15	about	about	ADP
bjp-69267	102	16	potential	potential	ADJ
bjp-69267	102	17	interference	interference	NOUN
bjp-69267	102	18	in	in	ADP
bjp-69267	102	19	biological	biological	ADJ
bjp-69267	102	20	assays	assay	NOUN
bjp-69267	102	21	and	and	CCONJ
bjp-69267	102	22	requires	require	VERB
bjp-69267	102	23	thorough	thorough	ADJ
bjp-69267	102	24	investigation	investigation	NOUN
bjp-69267	102	25	.	.	PUNCT
bjp-69267	103	1	however	however	ADV
bjp-69267	103	2	,	,	PUNCT
bjp-69267	103	3	the	the	DET
bjp-69267	103	4	compound	compound	NOUN
bjp-69267	103	5	's	's	PART
bjp-69267	103	6	adherence	adherence	NOUN
bjp-69267	103	7	to	to	PART
bjp-69267	103	8	lead	lead	VERB
bjp-69267	103	9	likeness	likeness	NOUN
bjp-69267	103	10	criteria	criterion	NOUN
bjp-69267	103	11	and	and	CCONJ
bjp-69267	103	12	its	its	PRON
bjp-69267	103	13	moderate	moderate	ADJ
bjp-69267	103	14	synthetic	synthetic	ADJ
bjp-69267	103	15	acessibility	acessibility	NOUN
bjp-69267	103	16	score	score	NOUN
bjp-69267	103	17	suggest	suggest	VERB
bjp-69267	103	18	feasible	feasible	ADJ
bjp-69267	103	19	pathways	pathway	NOUN
bjp-69267	103	20	for	for	ADP
bjp-69267	103	21	further	further	ADJ
bjp-69267	103	22	development	development	NOUN
bjp-69267	103	23	.	.	PUNCT
bjp-69267	104	1	toxicity	toxicity	NOUN
bjp-69267	104	2	assessment	assessment	NOUN
bjp-69267	104	3	utilized	utilize	VERB
bjp-69267	104	4	the	the	DET
bjp-69267	104	5	emoltox	emoltox	ADJ
bjp-69267	104	6	web	web	NOUN
bjp-69267	104	7	tool	tool	NOUN
bjp-69267	104	8	,	,	PUNCT
bjp-69267	104	9	analyzing	analyze	VERB
bjp-69267	104	10	various	various	ADJ
bjp-69267	104	11	drug	drug	NOUN
bjp-69267	104	12	components	component	NOUN
bjp-69267	104	13	(	(	PUNCT
bjp-69267	104	14	figure	figure	NOUN
bjp-69267	104	15	5	5	NUM
bjp-69267	104	16	)	)	PUNCT
bjp-69267	104	17	.	.	PUNCT
bjp-69267	105	1	the	the	DET
bjp-69267	105	2	tool	tool	NOUN
bjp-69267	105	3	provided	provide	VERB
bjp-69267	105	4	a	a	DET
bjp-69267	105	5	concise	concise	ADJ
bjp-69267	105	6	safety	safety	NOUN
bjp-69267	105	7	indication	indication	NOUN
bjp-69267	105	8	for	for	ADP
bjp-69267	105	9	human	human	ADJ
bjp-69267	105	10	use	use	NOUN
bjp-69267	105	11	,	,	PUNCT
bjp-69267	105	12	despite	despite	SCONJ
bjp-69267	105	13	strong	strong	ADJ
bjp-69267	105	14	therapeutic	therapeutic	ADJ
bjp-69267	105	15	properties	property	NOUN
bjp-69267	105	16	.	.	PUNCT
bjp-69267	106	1	data	data	NOUN
bjp-69267	106	2	-	-	PUNCT
bjp-69267	106	3	driven	drive	VERB
bjp-69267	106	4	models	model	NOUN
bjp-69267	106	5	revealed	reveal	VERB
bjp-69267	106	6	no	no	DET
bjp-69267	106	7	detected	detect	VERB
bjp-69267	106	8	toxic	toxic	ADJ
bjp-69267	106	9	actions	action	NOUN
bjp-69267	106	10	.	.	PUNCT
bjp-69267	107	1	however	however	ADV
bjp-69267	107	2	,	,	PUNCT
bjp-69267	107	3	the	the	DET
bjp-69267	107	4	emoltox	emoltox	ADJ
bjp-69267	107	5	tool	tool	NOUN
bjp-69267	107	6	identified	identify	VERB
bjp-69267	107	7	potential	potential	ADJ
bjp-69267	107	8	toxic	toxic	ADJ
bjp-69267	107	9	substructures	substructure	NOUN
bjp-69267	107	10	in	in	ADP
bjp-69267	107	11	the	the	DET
bjp-69267	107	12	molecular	molecular	ADJ
bjp-69267	107	13	representation	representation	NOUN
bjp-69267	107	14	.	.	PUNCT
bjp-69267	108	1	these	these	PRON
bjp-69267	108	2	included	include	VERB
bjp-69267	108	3	idiosyncratic	idiosyncratic	ADJ
bjp-69267	108	4	toxicity	toxicity	NOUN
bjp-69267	108	5	with	with	ADP
bjp-69267	108	6	metabolic	metabolic	NOUN
bjp-69267	108	7	activation	activation	NOUN
bjp-69267	108	8	,	,	PUNCT
bjp-69267	108	9	an	an	DET
bjp-69267	108	10	unpredictable	unpredictable	ADJ
bjp-69267	108	11	adverse	adverse	ADJ
bjp-69267	108	12	reaction	reaction	NOUN
bjp-69267	108	13	linked	link	VERB
bjp-69267	108	14	to	to	ADP
bjp-69267	108	15	the	the	DET
bjp-69267	108	16	body	body	NOUN
bjp-69267	108	17	's	's	PART
bjp-69267	108	18	metabolism	metabolism	NOUN
bjp-69267	108	19	converting	convert	VERB
bjp-69267	108	20	the	the	DET
bjp-69267	108	21	drug	drug	NOUN
bjp-69267	108	22	into	into	ADP
bjp-69267	108	23	harmful	harmful	ADJ
bjp-69267	108	24	compounds	compound	NOUN
bjp-69267	108	25	,	,	PUNCT
bjp-69267	108	26	covalent	covalent	ADJ
bjp-69267	108	27	bonds	bond	NOUN
bjp-69267	108	28	with	with	ADP
bjp-69267	108	29	dna	dna	NOUN
bjp-69267	108	30	forming	form	VERB
bjp-69267	108	31	strong	strong	ADJ
bjp-69267	108	32	,	,	PUNCT
bjp-69267	108	33	permanent	permanent	ADJ
bjp-69267	108	34	connections	connection	NOUN
bjp-69267	108	35	that	that	PRON
bjp-69267	108	36	could	could	AUX
bjp-69267	108	37	b	b	NOUN
bjp-69267	108	38	table	table	NOUN
bjp-69267	108	39	i	i	PRON
bjp-69267	108	40	inhibition	inhibition	VERB
bjp-69267	108	41	zones	zone	NOUN
bjp-69267	108	42	of	of	ADP
bjp-69267	108	43	pyrazoline	pyrazoline	NOUN
bjp-69267	108	44	carboxamide	carboxamide	NOUN
bjp-69267	108	45	and	and	CCONJ
bjp-69267	108	46	selected	select	VERB
bjp-69267	108	47	antibiotics	antibiotic	NOUN
bjp-69267	108	48	against	against	ADP
bjp-69267	108	49	tested	test	VERB
bjp-69267	108	50	microorganism	microorganism	NOUN
bjp-69267	108	51	strains	strain	NOUN
bjp-69267	108	52	synthetized	synthetize	VERB
bjp-69267	108	53	compound	compound	NOUN
bjp-69267	108	54	/	/	SYM
bjp-69267	108	55	antibiotics	antibiotic	NOUN
bjp-69267	108	56	inhibition	inhibition	NOUN
bjp-69267	108	57	zone	zone	NOUN
bjp-69267	108	58	(	(	PUNCT
bjp-69267	108	59	mm	mm	NOUN
bjp-69267	108	60	)	)	PUNCT
bjp-69267	108	61	concentration	concentration	NOUN
bjp-69267	108	62	escherichia	escherichia	NOUN
bjp-69267	108	63	coli	coli	NOUN
bjp-69267	108	64	staphylococcus	staphylococcus	NOUN
bjp-69267	108	65	aureus	aureus	NOUN
bjp-69267	108	66	listeria	listeria	VERB
bjp-69267	108	67	monocytogenes	monocytogene	NOUN
bjp-69267	108	68	pseudomonas	pseudomona	NOUN
bjp-69267	108	69	aeruginosa	aeruginosa	NOUN
bjp-69267	108	70	candida	candida	NOUN
bjp-69267	108	71	albicans	albican	NOUN
bjp-69267	108	72	pyrazoline	pyrazoline	NOUN
bjp-69267	108	73	carboxamide	carboxamide	VERB
bjp-69267	108	74	5000	5000	NUM
bjp-69267	108	75	µg	µg	NOUN
bjp-69267	108	76	/	/	SYM
bjp-69267	108	77	ml	ml	ADP
bjp-69267	108	78	a13.8	a13.8	PROPN
bjp-69267	108	79	±	±	PROPN
bjp-69267	108	80	0.8	0.8	NUM
bjp-69267	108	81	a13.2	a13.2	NUM
bjp-69267	108	82	±	±	NUM
bjp-69267	108	83	0.0	0.0	NUM
bjp-69267	108	84	b16.8	b16.8	PROPN
bjp-69267	108	85	±	±	NUM
bjp-69267	108	86	1.3	1.3	NUM
bjp-69267	108	87	c11.4	c11.4	PROPN
bjp-69267	108	88	±	±	NUM
bjp-69267	108	89	0.4	0.4	NUM
bjp-69267	108	90	b17.8	b17.8	NOUN
bjp-69267	108	91	±	±	NUM
bjp-69267	108	92	1.5	1.5	NUM
bjp-69267	108	93	2500	2500	NUM
bjp-69267	108	94	µg	µg	NOUN
bjp-69267	108	95	/	/	SYM
bjp-69267	108	96	ml	ml	ADP
bjp-69267	108	97	a11.8	a11.8	PROPN
bjp-69267	108	98	±	±	NUM
bjp-69267	108	99	0.2	0.2	NUM
bjp-69267	108	100	a12.2	a12.2	PROPN
bjp-69267	108	101	±	±	NUM
bjp-69267	108	102	0.0	0.0	NUM
bjp-69267	108	103	b15.3	b15.3	PROPN
bjp-69267	108	104	±	±	NUM
bjp-69267	108	105	0.0	0.0	NUM
bjp-69267	108	106	b12.8	b12.8	PROPN
bjp-69267	108	107	±	±	NUM
bjp-69267	108	108	1.1	1.1	NUM
bjp-69267	108	109	b13.8	b13.8	PROPN
bjp-69267	108	110	±	±	NUM
bjp-69267	108	111	0.7	0.7	NUM
bjp-69267	108	112	1250	1250	NUM
bjp-69267	108	113	µg	µg	NOUN
bjp-69267	108	114	/	/	SYM
bjp-69267	108	115	ml	ml	PROPN
bjp-69267	108	116	11.3	11.3	NUM
bjp-69267	108	117	±	±	NOUN
bjp-69267	108	118	0.1a	0.1a	NOUN
bjp-69267	109	1	b14.1	b14.1	PROPN
bjp-69267	109	2	±	±	NOUN
bjp-69267	109	3	0.2	0.2	NUM
bjp-69267	109	4	c15.4	c15.4	PROPN
bjp-69267	109	5	±	±	NUM
bjp-69267	109	6	0.4	0.4	NUM
bjp-69267	109	7	a12.0	a12.0	PROPN
bjp-69267	109	8	±	±	NOUN
bjp-69267	109	9	0.2	0.2	NUM
bjp-69267	109	10	a10.9	a10.9	NUM
bjp-69267	109	11	±	±	NUM
bjp-69267	109	12	0.6	0.6	NUM
bjp-69267	109	13	630	630	NUM
bjp-69267	109	14	µg	µg	ADJ
bjp-69267	109	15	/	/	SYM
bjp-69267	109	16	ml	ml	ADP
bjp-69267	109	17	a12.1	a12.1	PROPN
bjp-69267	109	18	±	±	NUM
bjp-69267	109	19	0.4	0.4	NUM
bjp-69267	109	20	a10.9	a10.9	PROPN
bjp-69267	109	21	±	±	NUM
bjp-69267	109	22	0.7	0.7	NUM
bjp-69267	109	23	b14.2	b14.2	NUM
bjp-69267	109	24	±	±	NUM
bjp-69267	109	25	0.0	0.0	NUM
bjp-69267	109	26	a11.2	a11.2	PROPN
bjp-69267	109	27	±	±	NUM
bjp-69267	109	28	0.0	0.0	NUM
bjp-69267	109	29	a11.3	a11.3	PROPN
bjp-69267	109	30	±	±	NUM
bjp-69267	109	31	0.3	0.3	NUM
bjp-69267	109	32	312	312	NUM
bjp-69267	109	33	µg	µg	NOUN
bjp-69267	109	34	/	/	SYM
bjp-69267	109	35	ml	ml	NOUN
bjp-69267	109	36	a13.4	a13.4	NOUN
bjp-69267	109	37	±	±	NUM
bjp-69267	109	38	0.6	0.6	NUM
bjp-69267	109	39	a12.8	a12.8	PROPN
bjp-69267	109	40	±	±	NUM
bjp-69267	109	41	0.7	0.7	NUM
bjp-69267	109	42	b16.3	b16.3	NOUN
bjp-69267	109	43	±	±	NUM
bjp-69267	109	44	0.9	0.9	NUM
bjp-69267	109	45	b11.7	b11.7	PROPN
bjp-69267	109	46	±	±	NUM
bjp-69267	109	47	0.4	0.4	NUM
bjp-69267	109	48	c11.5	c11.5	NUM
bjp-69267	109	49	±	±	NUM
bjp-69267	109	50	0.5	0.5	NUM
bjp-69267	109	51	gentamicin	gentamicin	NOUN
bjp-69267	109	52	50	50	NUM
bjp-69267	109	53	µg	µg	NOUN
bjp-69267	109	54	/	/	SYM
bjp-69267	109	55	disc	disc	NOUN
bjp-69267	109	56	a31.8	a31.8	NUM
bjp-69267	109	57	±	±	NUM
bjp-69267	109	58	0.2	0.2	NUM
bjp-69267	109	59	b18.9	b18.9	PROPN
bjp-69267	109	60	±	±	NUM
bjp-69267	109	61	0.4	0.4	NUM
bjp-69267	109	62	c32.1	c32.1	PROPN
bjp-69267	109	63	±	±	NUM
bjp-69267	109	64	4.9	4.9	NUM
bjp-69267	109	65	c35.7	c35.7	NOUN
bjp-69267	109	66	±	±	NUM
bjp-69267	109	67	0.0	0.0	NUM
bjp-69267	109	68	nil	nil	NOUN
bjp-69267	109	69	pipemidic	pipemidic	ADJ
bjp-69267	109	70	acid	acid	NOUN
bjp-69267	109	71	30	30	NUM
bjp-69267	109	72	µg	µg	NOUN
bjp-69267	109	73	/	/	SYM
bjp-69267	109	74	disc	disc	NOUN
bjp-69267	109	75	a13.9	a13.9	PROPN
bjp-69267	109	76	±	±	NUM
bjp-69267	109	77	0.4	0.4	NUM
bjp-69267	109	78	a14.6	a14.6	PROPN
bjp-69267	109	79	±	±	NUM
bjp-69267	109	80	0.3	0.3	NUM
bjp-69267	109	81	nil	nil	NOUN
bjp-69267	109	82	nil	nil	NOUN
bjp-69267	109	83	nil	nil	NOUN
bjp-69267	109	84	cefazolin	cefazolin	NOUN
bjp-69267	109	85	20	20	NUM
bjp-69267	109	86	µg	µg	NOUN
bjp-69267	109	87	/	/	SYM
bjp-69267	109	88	disc	disc	NOUN
bjp-69267	109	89	nil	nil	PROPN
bjp-69267	109	90	a28.9	a28.9	PROPN
bjp-69267	109	91	±	±	NUM
bjp-69267	109	92	0.8	0.8	NUM
bjp-69267	109	93	nil	nil	NOUN
bjp-69267	109	94	a26.2	a26.2	PROPN
bjp-69267	109	95	±	±	NUM
bjp-69267	109	96	1.6	1.6	NUM
bjp-69267	109	97	nil	nil	NOUN
bjp-69267	109	98	colistin	colistin	NOUN
bjp-69267	109	99	10	10	NUM
bjp-69267	109	100	µg	µg	NOUN
bjp-69267	109	101	/	/	SYM
bjp-69267	109	102	disc	disc	NOUN
bjp-69267	109	103	nil	nil	NOUN
bjp-69267	109	104	nil	nil	NOUN
bjp-69267	109	105	nil	nil	NOUN
bjp-69267	109	106	13.3	13.3	NUM
bjp-69267	109	107	±	±	NUM
bjp-69267	109	108	0.2	0.2	NUM
bjp-69267	109	109	nil	nil	NOUN
bjp-69267	109	110	data	datum	NOUN
bjp-69267	109	111	are	be	AUX
bjp-69267	109	112	mean	mean	NOUN
bjp-69267	109	113	±	±	NUM
bjp-69267	109	114	sd	sd	NOUN
bjp-69267	109	115	;	;	PUNCT
bjp-69267	109	116	n=3	n=3	NUM
bjp-69267	109	117	;	;	PUNCT
bjp-69267	109	118	the	the	DET
bjp-69267	109	119	superscripts	superscript	NOUN
bjp-69267	109	120	(	(	PUNCT
bjp-69267	109	121	a	a	DET
bjp-69267	109	122	-	-	PUNCT
bjp-69267	109	123	e	e	NOUN
bjp-69267	109	124	)	)	PUNCT
bjp-69267	109	125	indicate	indicate	VERB
bjp-69267	109	126	:	:	PUNCT
bjp-69267	109	127	values	value	NOUN
bjp-69267	109	128	that	that	PRON
bjp-69267	109	129	share	share	VERB
bjp-69267	109	130	the	the	DET
bjp-69267	109	131	same	same	ADJ
bjp-69267	109	132	superscript	superscript	NOUN
bjp-69267	109	133	letters	letter	NOUN
bjp-69267	109	134	do	do	AUX
bjp-69267	109	135	not	not	PART
bjp-69267	109	136	differ	differ	VERB
bjp-69267	109	137	significantly	significantly	ADV
bjp-69267	109	138	,	,	PUNCT
bjp-69267	109	139	while	while	SCONJ
bjp-69267	109	140	those	those	PRON
bjp-69267	109	141	do	do	AUX
bjp-69267	109	142	not	not	PART
bjp-69267	109	143	share	share	VERB
bjp-69267	109	144	the	the	DET
bjp-69267	109	145	same	same	ADJ
bjp-69267	109	146	letter	letter	NOUN
bjp-69267	109	147	differ	differ	VERB
bjp-69267	109	148	significantly	significantly	ADV
bjp-69267	109	149	figure	figure	VERB
bjp-69267	109	150	4	4	NUM
bjp-69267	109	151	:	:	PUNCT
bjp-69267	109	152	oral	oral	ADJ
bjp-69267	109	153	bioavailability	bioavailability	NOUN
bjp-69267	109	154	graph	graph	NOUN
bjp-69267	109	155	from	from	ADP
bjp-69267	109	156	the	the	DET
bjp-69267	109	157	swissadme	swissadme	PROPN
bjp-69267	109	158	database	database	NOUN
bjp-69267	109	159	.	.	PUNCT
bjp-69267	110	1	the	the	DET
bjp-69267	110	2	colored	colored	ADJ
bjp-69267	110	3	zone	zone	NOUN
bjp-69267	110	4	indicates	indicate	VERB
bjp-69267	110	5	the	the	DET
bjp-69267	110	6	physicochemical	physicochemical	ADJ
bjp-69267	110	7	space	space	NOUN
bjp-69267	110	8	for	for	ADP
bjp-69267	110	9	oral	oral	ADJ
bjp-69267	110	10	bioavailability	bioavailability	NOUN
bjp-69267	110	11	,	,	PUNCT
bjp-69267	110	12	and	and	CCONJ
bjp-69267	110	13	the	the	DET
bjp-69267	110	14	red	red	ADJ
bjp-69267	110	15	line	line	NOUN
bjp-69267	110	16	defines	define	VERB
bjp-69267	110	17	the	the	DET
bjp-69267	110	18	oral	oral	ADJ
bjp-69267	110	19	bioavailability	bioavailability	NOUN
bjp-69267	110	20	properties	property	NOUN
bjp-69267	110	21	of	of	ADP
bjp-69267	110	22	pyr	pyr	NOUN
bjp-69267	110	23	(	(	PUNCT
bjp-69267	110	24	a	a	NOUN
bjp-69267	110	25	)	)	PUNCT
bjp-69267	110	26	.	.	PUNCT
bjp-69267	111	1	boiled	boil	VERB
bjp-69267	111	2	-	-	PUNCT
bjp-69267	111	3	egg	egg	NOUN
bjp-69267	111	4	plot	plot	NOUN
bjp-69267	111	5	from	from	ADP
bjp-69267	111	6	the	the	DET
bjp-69267	111	7	swissadme	swissadme	PROPN
bjp-69267	111	8	database	database	NOUN
bjp-69267	111	9	reveals	reveal	VERB
bjp-69267	111	10	human	human	ADJ
bjp-69267	111	11	-	-	PUNCT
bjp-69267	111	12	blood	blood	NOUN
bjp-69267	111	13	–	–	PUNCT
bjp-69267	111	14	brain	brain	NOUN
bjp-69267	111	15	barrier	barrier	NOUN
bjp-69267	111	16	absorption	absorption	NOUN
bjp-69267	111	17	and	and	CCONJ
bjp-69267	111	18	the	the	DET
bjp-69267	111	19	red	red	ADJ
bjp-69267	111	20	dot	dot	NOUN
bjp-69267	111	21	indicates	indicate	VERB
bjp-69267	111	22	that	that	SCONJ
bjp-69267	111	23	the	the	DET
bjp-69267	111	24	molecule	molecule	NOUN
bjp-69267	111	25	is	be	AUX
bjp-69267	111	26	predicted	predict	VERB
bjp-69267	111	27	not	not	PART
bjp-69267	111	28	to	to	PART
bjp-69267	111	29	be	be	AUX
bjp-69267	111	30	effluent	effluent	ADJ
bjp-69267	111	31	from	from	ADP
bjp-69267	111	32	the	the	DET
bjp-69267	111	33	central	central	ADJ
bjp-69267	111	34	nervous	nervous	ADJ
bjp-69267	111	35	system	system	NOUN
bjp-69267	111	36	by	by	ADP
bjp-69267	111	37	p	p	NOUN
bjp-69267	111	38	-	-	PUNCT
bjp-69267	111	39	glycoprotein	glycoprotein	NOUN
bjp-69267	111	40	(	(	PUNCT
bjp-69267	111	41	b	b	NOUN
bjp-69267	111	42	)	)	PUNCT
bjp-69267	111	43	.	.	PUNCT
bjp-69267	112	1	lipo	lipo	NOUN
bjp-69267	112	2	:	:	PUNCT
bjp-69267	112	3	lipophilicity	lipophilicity	NOUN
bjp-69267	112	4	,	,	PUNCT
bjp-69267	112	5	polar	polar	ADJ
bjp-69267	112	6	:	:	PUNCT
bjp-69267	112	7	polarity	polarity	NOUN
bjp-69267	112	8	,	,	PUNCT
bjp-69267	112	9	insolu	insolu	VERB
bjp-69267	112	10	:	:	PUNCT
bjp-69267	112	11	insolubility	insolubility	NOUN
bjp-69267	112	12	,	,	PUNCT
bjp-69267	112	13	insatu	insatu	NOUN
bjp-69267	112	14	:	:	PUNCT
bjp-69267	112	15	unsaturation	unsaturation	ADJ
bjp-69267	112	16	,	,	PUNCT
bjp-69267	112	17	flex	flex	ADJ
bjp-69267	112	18	:	:	PUNCT
bjp-69267	112	19	flexibility	flexibility	NOUN
bjp-69267	112	20	,	,	PUNCT
bjp-69267	112	21	bbb	bbb	NOUN
bjp-69267	112	22	:	:	PUNCT
bjp-69267	112	23	blood	blood	NOUN
bjp-69267	112	24	–	–	PUNCT
bjp-69267	112	25	brain	brain	NOUN
bjp-69267	112	26	barrier	barrier	NOUN
bjp-69267	112	27	,	,	PUNCT
bjp-69267	112	28	hia	hia	PROPN
bjp-69267	112	29	:	:	PUNCT
bjp-69267	112	30	human	human	ADJ
bjp-69267	112	31	intestinal	intestinal	ADJ
bjp-69267	112	32	absorption	absorption	NOUN
bjp-69267	112	33	,	,	PUNCT
bjp-69267	112	34	pgp+	pgp+	PROPN
bjp-69267	112	35	:	:	PUNCT
bjp-69267	112	36	p	p	ADJ
bjp-69267	112	37	-	-	PUNCT
bjp-69267	112	38	glycoprotein	glycoprotein	NOUN
bjp-69267	112	39	substrate	substrate	NOUN
bjp-69267	112	40	,	,	PUNCT
bjp-69267	112	41	and	and	CCONJ
bjp-69267	112	42	pgp-	pgp-	X
bjp-69267	112	43	:	:	PUNCT
bjp-69267	112	44	not	not	PART
bjp-69267	112	45	a	a	DET
bjp-69267	112	46	p	p	ADJ
bjp-69267	112	47	-	-	PUNCT
bjp-69267	112	48	glycoprotein	glycoprotein	NOUN
bjp-69267	112	49	substrate	substrate	NOUN
bjp-69267	112	50	a	a	DET
bjp-69267	112	51	b	b	PROPN
bjp-69267	112	52	bangladesh	bangladesh	NOUN
bjp-69267	112	53	j	j	PROPN
bjp-69267	112	54	pharmacol	pharmacol	PROPN
bjp-69267	112	55	2023	2023	NUM
bjp-69267	112	56	;	;	PUNCT
bjp-69267	112	57	18	18	NUM
bjp-69267	112	58	:	:	SYM
bjp-69267	112	59	152	152	NUM
bjp-69267	112	60	-	-	SYM
bjp-69267	112	61	161	161	NUM
bjp-69267	112	62	157	157	NUM
bjp-69267	112	63	interfere	interfere	ADJ
bjp-69267	112	64	with	with	ADP
bjp-69267	112	65	replication	replication	NOUN
bjp-69267	112	66	or	or	CCONJ
bjp-69267	112	67	transcription	transcription	NOUN
bjp-69267	112	68	,	,	PUNCT
bjp-69267	112	69	and	and	CCONJ
bjp-69267	112	70	toxic	toxic	ADJ
bjp-69267	112	71	substructures	substructure	NOUN
bjp-69267	112	72	associated	associate	VERB
bjp-69267	112	73	with	with	ADP
bjp-69267	112	74	hepatotoxicity	hepatotoxicity	NOUN
bjp-69267	112	75	(	(	PUNCT
bjp-69267	112	76	figure	figure	NOUN
bjp-69267	112	77	5	5	NUM
bjp-69267	112	78	)	)	PUNCT
bjp-69267	112	79	.	.	PUNCT
bjp-69267	113	1	molecular	molecular	ADJ
bjp-69267	113	2	interaction	interaction	NOUN
bjp-69267	113	3	assessment	assessment	NOUN
bjp-69267	113	4	examining	examine	VERB
bjp-69267	113	5	the	the	DET
bjp-69267	113	6	data	datum	NOUN
bjp-69267	113	7	,	,	PUNCT
bjp-69267	113	8	in	in	ADP
bjp-69267	113	9	the	the	DET
bjp-69267	113	10	context	context	NOUN
bjp-69267	113	11	of	of	ADP
bjp-69267	113	12	the	the	DET
bjp-69267	113	13	protein	protein	NOUN
bjp-69267	113	14	with	with	ADP
bjp-69267	113	15	pdb	pdb	PROPN
bjp-69267	113	16	i	i	PROPN
bjp-69267	113	17	d	d	PROPN
bjp-69267	113	18	1kzn	1kzn	PROPN
bjp-69267	113	19	,	,	PUNCT
bjp-69267	113	20	pyrazoline	pyrazoline	NOUN
bjp-69267	113	21	carboxamide	carboxamide	NOUN
bjp-69267	113	22	demonstrated	demonstrate	VERB
bjp-69267	113	23	a	a	DET
bjp-69267	113	24	binding	bind	VERB
bjp-69267	113	25	affinity	affinity	NOUN
bjp-69267	113	26	of	of	ADP
bjp-69267	113	27	-7.9	-7.9	INTJ
bjp-69267	113	28	kcal	kcal	NOUN
bjp-69267	113	29	/	/	SYM
bjp-69267	113	30	mol	mol	PROPN
bjp-69267	113	31	(	(	PUNCT
bjp-69267	113	32	table	table	NOUN
bjp-69267	113	33	ii	ii	PROPN
bjp-69267	113	34	)	)	PUNCT
bjp-69267	113	35	.	.	PUNCT
bjp-69267	114	1	the	the	DET
bjp-69267	114	2	interaction	interaction	NOUN
bjp-69267	114	3	involved	involve	VERB
bjp-69267	114	4	specific	specific	ADJ
bjp-69267	114	5	residues	residue	NOUN
bjp-69267	114	6	,	,	PUNCT
bjp-69267	114	7	including	include	VERB
bjp-69267	114	8	asp	asp	PROPN
bjp-69267	114	9	a:49	a:49	ADJ
bjp-69267	114	10	,	,	PUNCT
bjp-69267	114	11	glu	glu	PROPN
bjp-69267	114	12	a:50	a:50	PROPN
bjp-69267	114	13	,	,	PUNCT
bjp-69267	114	14	gly	gly	ADJ
bjp-69267	114	15	a:77	a:77	NOUN
bjp-69267	114	16	,	,	PUNCT
bjp-69267	114	17	and	and	CCONJ
bjp-69267	114	18	ile	ile	PROPN
bjp-69267	114	19	a:78	a:78	NOUN
bjp-69267	114	20	.	.	PUNCT
bjp-69267	115	1	in	in	ADP
bjp-69267	115	2	contrast	contrast	NOUN
bjp-69267	115	3	,	,	PUNCT
bjp-69267	115	4	the	the	DET
bjp-69267	115	5	reference	reference	NOUN
bjp-69267	115	6	standard	standard	ADJ
bjp-69267	115	7	inhibitor	inhibitor	NOUN
bjp-69267	115	8	,	,	PUNCT
bjp-69267	115	9	clorobiocin	clorobiocin	PROPN
bjp-69267	115	10	,	,	PUNCT
bjp-69267	115	11	boasts	boast	VERB
bjp-69267	115	12	a	a	DET
bjp-69267	115	13	slightly	slightly	ADV
bjp-69267	115	14	enhanced	enhanced	ADJ
bjp-69267	115	15	binding	bind	VERB
bjp-69267	115	16	affinity	affinity	NOUN
bjp-69267	115	17	of	of	ADP
bjp-69267	115	18	-8.2	-8.2	PROPN
bjp-69267	115	19	kcal	kcal	PROPN
bjp-69267	115	20	/	/	SYM
bjp-69267	115	21	mol	mol	PROPN
bjp-69267	115	22	.	.	PUNCT
bjp-69267	116	1	the	the	DET
bjp-69267	116	2	engagement	engagement	NOUN
bjp-69267	116	3	of	of	ADP
bjp-69267	116	4	clorobiocin	clorobiocin	PROPN
bjp-69267	116	5	entailed	entail	VERB
bjp-69267	116	6	a	a	DET
bjp-69267	116	7	distinct	distinct	ADJ
bjp-69267	116	8	set	set	NOUN
bjp-69267	116	9	of	of	ADP
bjp-69267	116	10	residues	residue	NOUN
bjp-69267	116	11	,	,	PUNCT
bjp-69267	116	12	such	such	ADJ
bjp-69267	116	13	as	as	ADP
bjp-69267	116	14	ile	ile	PROPN
bjp-69267	116	15	a:48	a:48	PROPN
bjp-69267	116	16	,	,	PUNCT
bjp-69267	116	17	leu	leu	PROPN
bjp-69267	116	18	a:52	a:52	PROPN
bjp-69267	116	19	,	,	PUNCT
bjp-69267	116	20	gly	gly	ADV
bjp-69267	116	21	a:117	a:117	PROPN
bjp-69267	116	22	,	,	PUNCT
bjp-69267	116	23	asn	asn	PROPN
bjp-69267	116	24	a:46	a:46	PROPN
bjp-69267	116	25	,	,	PUNCT
bjp-69267	116	26	val	val	PROPN
bjp-69267	116	27	a:43	a:43	PROPN
bjp-69267	116	28	,	,	PUNCT
bjp-69267	116	29	val	val	PROPN
bjp-69267	116	30	a:120	a:120	ADJ
bjp-69267	116	31	,	,	PUNCT
bjp-69267	116	32	val	val	ADJ
bjp-69267	116	33	a:167	a:167	NOUN
bjp-69267	116	34	,	,	PUNCT
bjp-69267	116	35	gly	gly	ADV
bjp-69267	116	36	a:77	a:77	PROPN
bjp-69267	116	37	,	,	PUNCT
bjp-69267	116	38	glu	glu	PROPN
bjp-69267	116	39	a:42	a:42	PROPN
bjp-69267	116	40	,	,	PUNCT
bjp-69267	116	41	and	and	CCONJ
bjp-69267	116	42	asp	asp	PROPN
bjp-69267	116	43	a:49	a:49	ADJ
bjp-69267	116	44	.	.	PUNCT
bjp-69267	117	1	turning	turn	VERB
bjp-69267	117	2	to	to	ADP
bjp-69267	117	3	the	the	DET
bjp-69267	117	4	protein	protein	NOUN
bjp-69267	117	5	with	with	ADP
bjp-69267	117	6	pdb	pdb	PROPN
bjp-69267	117	7	i	i	PROPN
bjp-69267	117	8	d	d	PROPN
bjp-69267	117	9	3hun	3hun	PROPN
bjp-69267	117	10	,	,	PUNCT
bjp-69267	117	11	pyr	pyr	NOUN
bjp-69267	117	12	's	's	PART
bjp-69267	117	13	interaction	interaction	NOUN
bjp-69267	117	14	was	be	AUX
bjp-69267	117	15	characterized	characterize	VERB
bjp-69267	117	16	by	by	ADP
bjp-69267	117	17	binding	bind	VERB
bjp-69267	117	18	energy	energy	NOUN
bjp-69267	117	19	of	of	ADP
bjp-69267	117	20	-7.9	-7.9	ADJ
bjp-69267	117	21	kcal	kcal	PROPN
bjp-69267	117	22	/	/	SYM
bjp-69267	117	23	mol	mol	PROPN
bjp-69267	117	24	,	,	PUNCT
bjp-69267	117	25	involving	involve	VERB
bjp-69267	117	26	residues	residue	NOUN
bjp-69267	117	27	like	like	ADP
bjp-69267	117	28	lys	lys	NOUN
bjp-69267	117	29	a:221	a:221	NOUN
bjp-69267	117	30	,	,	PUNCT
bjp-69267	117	31	ala	ala	PROPN
bjp-69267	117	32	b:129	b:129	PROPN
bjp-69267	117	33	,	,	PUNCT
bjp-69267	117	34	and	and	CCONJ
bjp-69267	117	35	asp	asp	PROPN
bjp-69267	117	36	b:130	b:130	NOUN
bjp-69267	117	37	.	.	PUNCT
bjp-69267	118	1	comparatively	comparatively	ADV
bjp-69267	118	2	,	,	PUNCT
bjp-69267	118	3	the	the	DET
bjp-69267	118	4	standard	standard	ADJ
bjp-69267	118	5	inhibitor	inhibitor	NOUN
bjp-69267	118	6	ampicillin	ampicillin	PROPN
bjp-69267	118	7	showed	show	VERB
bjp-69267	118	8	a	a	DET
bjp-69267	118	9	binding	bind	VERB
bjp-69267	118	10	affinity	affinity	NOUN
bjp-69267	118	11	of	of	ADP
bjp-69267	118	12	-7.4	-7.4	PRON
bjp-69267	118	13	kcal	kcal	PROPN
bjp-69267	118	14	/	/	SYM
bjp-69267	118	15	mol	mol	PROPN
bjp-69267	118	16	,	,	PUNCT
bjp-69267	118	17	with	with	ADP
bjp-69267	118	18	residues	residue	NOUN
bjp-69267	118	19	thr	thr	PROPN
bjp-69267	118	20	b:232	b:232	PROPN
bjp-69267	118	21	,	,	PUNCT
bjp-69267	118	22	lys	lys	PROPN
bjp-69267	118	23	b:221	b:221	PROPN
bjp-69267	118	24	,	,	PUNCT
bjp-69267	118	25	leu	leu	PROPN
bjp-69267	118	26	a:96	a:96	PROPN
bjp-69267	118	27	,	,	PUNCT
bjp-69267	118	28	and	and	CCONJ
bjp-69267	118	29	lys	lys	PROPN
bjp-69267	118	30	a:221	a:221	NOUN
bjp-69267	118	31	implicated	implicate	VERB
bjp-69267	118	32	in	in	ADP
bjp-69267	118	33	the	the	DET
bjp-69267	118	34	interaction	interaction	NOUN
bjp-69267	118	35	.	.	PUNCT
bjp-69267	119	1	for	for	ADP
bjp-69267	119	2	the	the	DET
bjp-69267	119	3	protein	protein	NOUN
bjp-69267	119	4	identified	identify	VERB
bjp-69267	119	5	by	by	ADP
bjp-69267	119	6	pdb	pdb	PROPN
bjp-69267	119	7	i	i	PROPN
bjp-69267	119	8	d	d	PROPN
bjp-69267	119	9	7kcy	7kcy	PROPN
bjp-69267	119	10	,	,	PUNCT
bjp-69267	119	11	pyr	pyr	NOUN
bjp-69267	119	12	's	's	PART
bjp-69267	119	13	affinity	affinity	NOUN
bjp-69267	119	14	of	of	ADP
bjp-69267	119	15	-5.6	-5.6	ADJ
bjp-69267	119	16	kcal/	kcal/	NUM
bjp-69267	119	17	d	d	NOUN
bjp-69267	119	18	c	c	PROPN
bjp-69267	119	19	b	b	PROPN
bjp-69267	119	20	a	a	DET
bjp-69267	119	21	e	e	NOUN
bjp-69267	119	22	figure	figure	NOUN
bjp-69267	119	23	5	5	NUM
bjp-69267	119	24	:	:	PUNCT
bjp-69267	119	25	potential	potential	ADJ
bjp-69267	119	26	toxicity	toxicity	NOUN
bjp-69267	119	27	prediction	prediction	NOUN
bjp-69267	119	28	of	of	ADP
bjp-69267	119	29	the	the	DET
bjp-69267	119	30	novel	novel	ADJ
bjp-69267	119	31	pyrazoline	pyrazoline	NOUN
bjp-69267	119	32	carboxamide	carboxamide	NOUN
bjp-69267	119	33	and	and	CCONJ
bjp-69267	119	34	its	its	PRON
bjp-69267	119	35	eventual	eventual	ADJ
bjp-69267	119	36	toxic	toxic	ADJ
bjp-69267	119	37	substructures	substructure	NOUN
bjp-69267	119	38	(	(	PUNCT
bjp-69267	119	39	highlighted	highlight	VERB
bjp-69267	119	40	in	in	ADP
bjp-69267	119	41	red	red	PROPN
bjp-69267	119	42	)	)	PUNCT
bjp-69267	119	43	.	.	PUNCT
bjp-69267	120	1	molecule	molecule	NOUN
bjp-69267	120	2	depiction	depiction	NOUN
bjp-69267	120	3	(	(	PUNCT
bjp-69267	120	4	a	a	NOUN
bjp-69267	120	5	)	)	PUNCT
bjp-69267	120	6	.	.	PUNCT
bjp-69267	121	1	idiosyncratic	idiosyncratic	ADJ
bjp-69267	121	2	toxicity	toxicity	NOUN
bjp-69267	121	3	(	(	PUNCT
bjp-69267	121	4	b	b	NOUN
bjp-69267	121	5	)	)	PUNCT
bjp-69267	121	6	.	.	PUNCT
bjp-69267	122	1	covalent	covalent	NOUN
bjp-69267	122	2	binds	bind	VERB
bjp-69267	122	3	with	with	ADP
bjp-69267	122	4	dna	dna	PROPN
bjp-69267	122	5	(	(	PUNCT
bjp-69267	122	6	c	c	NOUN
bjp-69267	122	7	and	and	CCONJ
bjp-69267	122	8	d	d	NOUN
bjp-69267	122	9	)	)	PUNCT
bjp-69267	122	10	.	.	PUNCT
bjp-69267	123	1	hepatotoxicity	hepatotoxicity	NOUN
bjp-69267	123	2	(	(	PUNCT
bjp-69267	123	3	e	e	NOUN
bjp-69267	123	4	)	)	PUNCT
bjp-69267	123	5	table	table	NOUN
bjp-69267	123	6	ii	ii	NOUN
bjp-69267	123	7	binding	bind	VERB
bjp-69267	123	8	affinity	affinity	NOUN
bjp-69267	123	9	and	and	CCONJ
bjp-69267	123	10	molecular	molecular	ADJ
bjp-69267	123	11	interactions	interaction	NOUN
bjp-69267	123	12	of	of	ADP
bjp-69267	123	13	four	four	NUM
bjp-69267	123	14	antimicrobial	antimicrobial	ADJ
bjp-69267	123	15	target	target	NOUN
bjp-69267	123	16	proteins	protein	NOUN
bjp-69267	123	17	with	with	ADP
bjp-69267	123	18	a	a	DET
bjp-69267	123	19	novel	novel	ADJ
bjp-69267	123	20	pyrazoline	pyrazoline	NOUN
bjp-69267	123	21	carboxamide	carboxamide	NOUN
bjp-69267	123	22	and	and	CCONJ
bjp-69267	123	23	their	their	PRON
bjp-69267	123	24	respective	respective	ADJ
bjp-69267	123	25	standard	standard	ADJ
bjp-69267	123	26	inhibitors	inhibitor	NOUN
bjp-69267	123	27	pdb	pdb	VERB
bjp-69267	123	28	i	i	NOUN
bjp-69267	123	29	d	d	PROPN
bjp-69267	123	30	ligands	ligand	VERB
bjp-69267	123	31	estimated	estimate	VERB
bjp-69267	123	32	free	free	ADJ
bjp-69267	123	33	energy	energy	NOUN
bjp-69267	123	34	of	of	ADP
bjp-69267	123	35	binding	bind	VERB
bjp-69267	123	36	(	(	PUNCT
bjp-69267	123	37	kcal	kcal	PROPN
bjp-69267	123	38	/	/	SYM
bjp-69267	123	39	mol	mol	NOUN
bjp-69267	123	40	)	)	PUNCT
bjp-69267	123	41	residues	residue	NOUN
bjp-69267	123	42	involved	involve	VERB
bjp-69267	123	43	in	in	ADP
bjp-69267	123	44	bonded	bond	VERB
bjp-69267	123	45	interaction	interaction	NOUN
bjp-69267	123	46	1kzn	1kzn	NUM
bjp-69267	123	47	pyr	pyr	NOUN
bjp-69267	123	48	(	(	PUNCT
bjp-69267	123	49	designed	design	VERB
bjp-69267	123	50	)	)	PUNCT
bjp-69267	124	1	-7.9	-7.9	AUX
bjp-69267	124	2	asp	asp	PROPN
bjp-69267	124	3	a:49	a:49	NOUN
bjp-69267	124	4	,	,	PUNCT
bjp-69267	124	5	glu	glu	NOUN
bjp-69267	124	6	a	a	DET
bjp-69267	124	7	:	:	SYM
bjp-69267	124	8	50	50	NUM
bjp-69267	124	9	,	,	PUNCT
bjp-69267	124	10	gly	gly	ADJ
bjp-69267	124	11	a:77	a:77	NOUN
bjp-69267	124	12	,	,	PUNCT
bjp-69267	124	13	ile	ile	PROPN
bjp-69267	124	14	a	a	PRON
bjp-69267	124	15	:	:	PUNCT
bjp-69267	124	16	78	78	NUM
bjp-69267	124	17	clorobiocin	clorobiocin	NOUN
bjp-69267	124	18	(	(	PUNCT
bjp-69267	124	19	cid	cid	PROPN
bjp-69267	124	20	:	:	PUNCT
bjp-69267	124	21	54706138	54706138	NUM
bjp-69267	124	22	)	)	PUNCT
bjp-69267	125	1	-8.2	-8.2	PROPN
bjp-69267	125	2	ile	ile	PROPN
bjp-69267	125	3	a:48	a:48	PROPN
bjp-69267	125	4	,	,	PUNCT
bjp-69267	125	5	leu	leu	PROPN
bjp-69267	125	6	a:52	a:52	PROPN
bjp-69267	125	7	,	,	PUNCT
bjp-69267	125	8	gly	gly	ADV
bjp-69267	125	9	a:117	a:117	PROPN
bjp-69267	125	10	,	,	PUNCT
bjp-69267	125	11	asn	asn	PROPN
bjp-69267	125	12	a:46	a:46	PROPN
bjp-69267	125	13	,	,	PUNCT
bjp-69267	125	14	val	val	PROPN
bjp-69267	125	15	a:43	a:43	PROPN
bjp-69267	125	16	,	,	PUNCT
bjp-69267	125	17	val	val	PROPN
bjp-69267	125	18	a:120	a:120	ADJ
bjp-69267	125	19	,	,	PUNCT
bjp-69267	125	20	val	val	ADJ
bjp-69267	125	21	a:167	a:167	NOUN
bjp-69267	125	22	,	,	PUNCT
bjp-69267	125	23	gly	gly	ADV
bjp-69267	125	24	a:77	a:77	PROPN
bjp-69267	125	25	,	,	PUNCT
bjp-69267	125	26	glu	glu	PROPN
bjp-69267	125	27	a:42	a:42	PROPN
bjp-69267	125	28	,	,	PUNCT
bjp-69267	125	29	asp	asp	PROPN
bjp-69267	125	30	a:49	a:49	ADJ
bjp-69267	125	31	3hun	3hun	PROPN
bjp-69267	125	32	pyr	pyr	NOUN
bjp-69267	125	33	(	(	PUNCT
bjp-69267	125	34	designed	design	VERB
bjp-69267	125	35	)	)	PUNCT
bjp-69267	125	36	-7.9	-7.9	NOUN
bjp-69267	125	37	lys	lys	NOUN
bjp-69267	125	38	a:221	a:221	NOUN
bjp-69267	125	39	,	,	PUNCT
bjp-69267	125	40	ala	ala	PROPN
bjp-69267	125	41	b	b	NOUN
bjp-69267	125	42	:	:	PUNCT
bjp-69267	125	43	129	129	NUM
bjp-69267	125	44	,	,	PUNCT
bjp-69267	125	45	asp	asp	PROPN
bjp-69267	125	46	b	b	NOUN
bjp-69267	125	47	:	:	PUNCT
bjp-69267	125	48	130	130	NUM
bjp-69267	125	49	ampicillin	ampicillin	NOUN
bjp-69267	125	50	(	(	PUNCT
bjp-69267	125	51	cid	cid	NOUN
bjp-69267	125	52	:	:	PUNCT
bjp-69267	125	53	6249	6249	NUM
bjp-69267	125	54	)	)	PUNCT
bjp-69267	125	55	-7.4	-7.4	PUNCT
bjp-69267	125	56	thr	thr	PROPN
bjp-69267	125	57	b:232	b:232	PROPN
bjp-69267	125	58	,	,	PUNCT
bjp-69267	125	59	lys	lys	PROPN
bjp-69267	125	60	b	b	PROPN
bjp-69267	125	61	:	:	PUNCT
bjp-69267	125	62	221	221	NUM
bjp-69267	125	63	,	,	PUNCT
bjp-69267	125	64	leu	leu	PROPN
bjp-69267	125	65	a:96	a:96	PROPN
bjp-69267	125	66	,	,	PUNCT
bjp-69267	125	67	lys	lys	PROPN
bjp-69267	125	68	a:221	a:221	NOUN
bjp-69267	125	69	7kcy	7kcy	NUM
bjp-69267	125	70	pyr	pyr	NOUN
bjp-69267	125	71	(	(	PUNCT
bjp-69267	125	72	designed	design	VERB
bjp-69267	125	73	)	)	PUNCT
bjp-69267	125	74	-5.6	-5.6	ADJ
bjp-69267	125	75	gln	gln	PROPN
bjp-69267	125	76	a:57	a:57	PROPN
bjp-69267	125	77	,	,	PUNCT
bjp-69267	125	78	arg	arg	NOUN
bjp-69267	125	79	a:280	a:280	PROPN
bjp-69267	125	80	,	,	PUNCT
bjp-69267	125	81	lys	lys	VERB
bjp-69267	125	82	a	a	DET
bjp-69267	125	83	:	:	PUNCT
bjp-69267	125	84	275	275	NUM
bjp-69267	125	85	,	,	PUNCT
bjp-69267	125	86	leu	leu	PROPN
bjp-69267	125	87	a	a	DET
bjp-69267	125	88	223	223	NUM
bjp-69267	125	89	,	,	PUNCT
bjp-69267	125	90	pro	pro	X
bjp-69267	125	91	a:220	a:220	ADJ
bjp-69267	125	92	cefoxitin	cefoxitin	NOUN
bjp-69267	125	93	(	(	PUNCT
bjp-69267	125	94	cid	cid	NOUN
bjp-69267	125	95	:	:	PUNCT
bjp-69267	125	96	441199	441199	NUM
bjp-69267	125	97	)	)	PUNCT
bjp-69267	126	1	-4.3	-4.3	PROPN
bjp-69267	126	2	ile	ile	PROPN
bjp-69267	126	3	a:216	a:216	VERB
bjp-69267	126	4	,	,	PUNCT
bjp-69267	126	5	asp	asp	PROPN
bjp-69267	126	6	a:256	a:256	PROPN
bjp-69267	126	7	,	,	PUNCT
bjp-69267	126	8	lys	lys	PROPN
bjp-69267	126	9	a275	a275	PROPN
bjp-69267	126	10	pyr	pyr	NOUN
bjp-69267	126	11	(	(	PUNCT
bjp-69267	126	12	designed	design	VERB
bjp-69267	126	13	)	)	PUNCT
bjp-69267	126	14	-8.4	-8.4	PROPN
bjp-69267	126	15	glu	glu	PROPN
bjp-69267	126	16	a:420	a:420	NOUN
bjp-69267	126	17	,	,	PUNCT
bjp-69267	126	18	tyr	tyr	PROPN
bjp-69267	126	19	a	a	DET
bjp-69267	126	20	:	:	PUNCT
bjp-69267	126	21	69	69	NUM
bjp-69267	126	22	,	,	PUNCT
bjp-69267	126	23	tyr	tyr	PROPN
bjp-69267	126	24	a	a	DET
bjp-69267	126	25	:	:	SYM
bjp-69267	126	26	408	408	NUM
bjp-69267	126	27	,	,	PUNCT
bjp-69267	126	28	thr	thr	PROPN
bjp-69267	126	29	a411	a411	PROPN
bjp-69267	126	30	,	,	PUNCT
bjp-69267	126	31	gln	gln	VERB
bjp-69267	126	32	a	a	DET
bjp-69267	126	33	:	:	PUNCT
bjp-69267	126	34	77	77	NUM
bjp-69267	126	35	5tz1	5tz1	NUM
bjp-69267	126	36	oteseconazole	oteseconazole	NOUN
bjp-69267	126	37	(	(	PUNCT
bjp-69267	126	38	cid	cid	NOUN
bjp-69267	126	39	:	:	PUNCT
bjp-69267	126	40	92132724	92132724	NUM
bjp-69267	126	41	)	)	PUNCT
bjp-69267	127	1	-8.3	-8.3	ADJ
bjp-69267	127	2	lys	lys	NOUN
bjp-69267	127	3	b:499	b:499	PROPN
bjp-69267	127	4	,	,	PUNCT
bjp-69267	127	5	glu	glu	PROPN
bjp-69267	127	6	b	b	NOUN
bjp-69267	127	7	:	:	PUNCT
bjp-69267	127	8	420	420	NUM
bjp-69267	127	9	,	,	PUNCT
bjp-69267	127	10	val	val	ADJ
bjp-69267	127	11	b:500	b:500	NOUN
bjp-69267	127	12	,	,	PUNCT
bjp-69267	127	13	his	his	PRON
bjp-69267	127	14	b:373	b:373	NOUN
bjp-69267	127	15	,	,	PUNCT
bjp-69267	127	16	met	meet	VERB
bjp-69267	127	17	b:374	b:374	ADJ
bjp-69267	127	18	,	,	PUNCT
bjp-69267	127	19	met	meet	VERB
bjp-69267	127	20	b:372	b:372	PROPN
bjp-69267	127	21	,	,	PUNCT
bjp-69267	127	22	val	val	NOUN
bjp-69267	127	23	b:510	b:510	NOUN
bjp-69267	127	24	,	,	PUNCT
bjp-69267	127	25	pro	pro	ADJ
bjp-69267	127	26	b:503	b:503	PROPN
bjp-69267	127	27	,	,	PUNCT
bjp-69267	127	28	asp	asp	PROPN
bjp-69267	127	29	b:502	b:502	PROPN
bjp-69267	127	30	158	158	NUM
bjp-69267	127	31	bangladesh	bangladesh	PROPN
bjp-69267	127	32	j	j	PROPN
bjp-69267	127	33	pharmacol	pharmacol	PROPN
bjp-69267	127	34	2023	2023	NUM
bjp-69267	127	35	;	;	PUNCT
bjp-69267	127	36	18	18	NUM
bjp-69267	127	37	:	:	SYM
bjp-69267	127	38	152	152	NUM
bjp-69267	127	39	-	-	SYM
bjp-69267	127	40	161	161	NUM
bjp-69267	127	41	https://pubchem.ncbi.nlm.nih.gov/compound/92132724	https://pubchem.ncbi.nlm.nih.gov/compound/92132724	PROPN
bjp-69267	127	42	mol	mol	ADP
bjp-69267	127	43	was	be	AUX
bjp-69267	127	44	observed	observe	VERB
bjp-69267	127	45	through	through	ADP
bjp-69267	127	46	interactions	interaction	NOUN
bjp-69267	127	47	with	with	ADP
bjp-69267	127	48	residues	residue	NOUN
bjp-69267	127	49	gln	gln	PROPN
bjp-69267	127	50	a:57	a:57	PROPN
bjp-69267	127	51	,	,	PUNCT
bjp-69267	127	52	arg	arg	NOUN
bjp-69267	127	53	a:280	a:280	PROPN
bjp-69267	127	54	,	,	PUNCT
bjp-69267	127	55	lys	lys	PROPN
bjp-69267	127	56	a:275	a:275	PROPN
bjp-69267	127	57	,	,	PUNCT
bjp-69267	127	58	leu	leu	PROPN
bjp-69267	127	59	a:223	a:223	PROPN
bjp-69267	127	60	,	,	PUNCT
bjp-69267	127	61	and	and	CCONJ
bjp-69267	127	62	pro	pro	X
bjp-69267	127	63	a:220	a:220	ADJ
bjp-69267	127	64	.	.	PUNCT
bjp-69267	128	1	in	in	ADP
bjp-69267	128	2	contrast	contrast	NOUN
bjp-69267	128	3	,	,	PUNCT
bjp-69267	128	4	the	the	DET
bjp-69267	128	5	standard	standard	ADJ
bjp-69267	128	6	inhibitor	inhibitor	NOUN
bjp-69267	128	7	cefoxitin	cefoxitin	NOUN
bjp-69267	128	8	exhibited	exhibit	VERB
bjp-69267	128	9	a	a	DET
bjp-69267	128	10	binding	bind	VERB
bjp-69267	128	11	energy	energy	NOUN
bjp-69267	128	12	of	of	ADP
bjp-69267	128	13	-4.3	-4.3	PROPN
bjp-69267	128	14	kcal	kcal	PROPN
bjp-69267	128	15	/	/	SYM
bjp-69267	128	16	mol	mol	PROPN
bjp-69267	128	17	,	,	PUNCT
bjp-69267	128	18	involving	involve	VERB
bjp-69267	128	19	residues	residue	NOUN
bjp-69267	128	20	ile	ile	PROPN
bjp-69267	128	21	a:216	a:216	VERB
bjp-69267	128	22	,	,	PUNCT
bjp-69267	128	23	asp	asp	PROPN
bjp-69267	128	24	a:256	a:256	PROPN
bjp-69267	128	25	,	,	PUNCT
bjp-69267	128	26	and	and	CCONJ
bjp-69267	128	27	lys	lys	PROPN
bjp-69267	128	28	a:275	a:275	PROPN
bjp-69267	128	29	.	.	PUNCT
bjp-69267	129	1	lastly	lastly	ADV
bjp-69267	129	2	,	,	PUNCT
bjp-69267	129	3	with	with	ADP
bjp-69267	129	4	regards	regard	NOUN
bjp-69267	129	5	to	to	ADP
bjp-69267	129	6	the	the	DET
bjp-69267	129	7	protein	protein	NOUN
bjp-69267	129	8	denoted	denote	VERB
bjp-69267	129	9	by	by	ADP
bjp-69267	129	10	pdb	pdb	PROPN
bjp-69267	129	11	i	i	PROPN
bjp-69267	129	12	d	d	PROPN
bjp-69267	129	13	5tz1	5tz1	NUM
bjp-69267	129	14	,	,	PUNCT
bjp-69267	129	15	pyrazoline	pyrazoline	NOUN
bjp-69267	129	16	carboxamide	carboxamide	NOUN
bjp-69267	129	17	demonstrates	demonstrate	VERB
bjp-69267	129	18	a	a	DET
bjp-69267	129	19	notably	notably	ADV
bjp-69267	129	20	strong	strong	ADJ
bjp-69267	129	21	affinity	affinity	NOUN
bjp-69267	129	22	of	of	ADP
bjp-69267	129	23	-8.4	-8.4	X
bjp-69267	129	24	kcal	kcal	NOUN
bjp-69267	129	25	/	/	SYM
bjp-69267	129	26	mol	mol	PROPN
bjp-69267	129	27	.	.	PUNCT
bjp-69267	130	1	the	the	DET
bjp-69267	130	2	interaction	interaction	NOUN
bjp-69267	130	3	centers	center	NOUN
bjp-69267	130	4	around	around	ADP
bjp-69267	130	5	residues	residue	NOUN
bjp-69267	130	6	glu	glu	NOUN
bjp-69267	130	7	a:420	a:420	NOUN
bjp-69267	130	8	,	,	PUNCT
bjp-69267	130	9	tyr	tyr	PROPN
bjp-69267	130	10	a:69	a:69	PROPN
bjp-69267	130	11	,	,	PUNCT
bjp-69267	130	12	tyr	tyr	PROPN
bjp-69267	130	13	a:408	a:408	PROPN
bjp-69267	130	14	,	,	PUNCT
bjp-69267	130	15	thr	thr	PROPN
bjp-69267	130	16	a:411	a:411	ADJ
bjp-69267	130	17	,	,	PUNCT
bjp-69267	130	18	and	and	CCONJ
bjp-69267	130	19	gln	gln	PROPN
bjp-69267	130	20	a:77	a:77	PROPN
bjp-69267	130	21	.	.	PUNCT
bjp-69267	131	1	comparatively	comparatively	ADV
bjp-69267	131	2	,	,	PUNCT
bjp-69267	131	3	the	the	DET
bjp-69267	131	4	standard	standard	ADJ
bjp-69267	131	5	inhibitor	inhibitor	NOUN
bjp-69267	131	6	oteseconazole	oteseconazole	NOUN
bjp-69267	131	7	showed	show	VERB
bjp-69267	131	8	a	a	DET
bjp-69267	131	9	binding	bind	VERB
bjp-69267	131	10	energy	energy	NOUN
bjp-69267	131	11	of	of	ADP
bjp-69267	131	12	-8.3	-8.3	ADJ
bjp-69267	131	13	kcal	kcal	PROPN
bjp-69267	131	14	/	/	SYM
bjp-69267	131	15	mol	mol	PROPN
bjp-69267	131	16	,	,	PUNCT
bjp-69267	131	17	engaging	engage	VERB
bjp-69267	131	18	residues	residue	NOUN
bjp-69267	131	19	lys	lys	NOUN
bjp-69267	131	20	b:499	b:499	PROPN
bjp-69267	131	21	,	,	PUNCT
bjp-69267	131	22	glu	glu	NOUN
bjp-69267	131	23	b:420	b:420	NOUN
bjp-69267	131	24	,	,	PUNCT
bjp-69267	131	25	val	val	NOUN
bjp-69267	131	26	b:500	b:500	NOUN
bjp-69267	131	27	,	,	PUNCT
bjp-69267	131	28	his	his	PRON
bjp-69267	131	29	b:373	b:373	NOUN
bjp-69267	131	30	,	,	PUNCT
bjp-69267	131	31	met	meet	VERB
bjp-69267	131	32	b:374	b:374	ADJ
bjp-69267	131	33	,	,	PUNCT
bjp-69267	131	34	met	meet	VERB
bjp-69267	131	35	b:372	b:372	PROPN
bjp-69267	131	36	,	,	PUNCT
bjp-69267	131	37	val	val	NOUN
bjp-69267	131	38	b:510	b:510	NOUN
bjp-69267	131	39	,	,	PUNCT
bjp-69267	131	40	pro	pro	ADJ
bjp-69267	131	41	b:503	b:503	NOUN
bjp-69267	131	42	,	,	PUNCT
bjp-69267	131	43	and	and	CCONJ
bjp-69267	131	44	asp	asp	PROPN
bjp-69267	131	45	b:502	b:502	NOUN
bjp-69267	131	46	.	.	PUNCT
bjp-69267	132	1	molecular	molecular	ADJ
bjp-69267	132	2	dynamics	dynamic	NOUN
bjp-69267	132	3	study	study	VERB
bjp-69267	132	4	the	the	DET
bjp-69267	132	5	nma	nma	PROPN
bjp-69267	132	6	analysis	analysis	NOUN
bjp-69267	132	7	of	of	ADP
bjp-69267	132	8	docked	docked	ADJ
bjp-69267	132	9	complexes	complex	NOUN
bjp-69267	132	10	(	(	PUNCT
bjp-69267	132	11	1kzn	1kzn	NOUN
bjp-69267	132	12	-	-	PUNCT
bjp-69267	132	13	pyr	pyr	NOUN
bjp-69267	132	14	,	,	PUNCT
bjp-69267	132	15	3hun	3hun	PROPN
bjp-69267	132	16	-	-	PUNCT
bjp-69267	132	17	pyr	pyr	NOUN
bjp-69267	132	18	,	,	PUNCT
bjp-69267	132	19	7kcy	7kcy	NOUN
bjp-69267	132	20	-	-	NOUN
bjp-69267	132	21	pyr	pyr	NOUN
bjp-69267	132	22	,	,	PUNCT
bjp-69267	132	23	and	and	CCONJ
bjp-69267	132	24	5tz1	5tz1	NUM
bjp-69267	132	25	-	-	PUNCT
bjp-69267	132	26	pyr	pyr	NOUN
bjp-69267	132	27	)	)	PUNCT
bjp-69267	132	28	revealed	reveal	VERB
bjp-69267	132	29	distinct	distinct	ADJ
bjp-69267	132	30	mobility	mobility	NOUN
bjp-69267	132	31	profiles	profile	NOUN
bjp-69267	132	32	,	,	PUNCT
bjp-69267	132	33	with	with	ADP
bjp-69267	132	34	complex	complex	ADJ
bjp-69267	132	35	1kzn	1kzn	NUM
bjp-69267	132	36	-	-	PUNCT
bjp-69267	132	37	pyr	pyr	NOUN
bjp-69267	132	38	displaying	display	VERB
bjp-69267	132	39	the	the	DET
bjp-69267	132	40	highest	high	ADJ
bjp-69267	132	41	deformability	deformability	NOUN
bjp-69267	132	42	(	(	PUNCT
bjp-69267	132	43	supplementary	supplementary	ADJ
bjp-69267	132	44	figure	figure	NOUN
bjp-69267	132	45	1	1	NUM
bjp-69267	132	46	)	)	PUNCT
bjp-69267	132	47	.	.	PUNCT
bjp-69267	133	1	bfactor	bfactor	PROPN
bjp-69267	133	2	diagrams	diagram	NOUN
bjp-69267	133	3	compare	compare	VERB
bjp-69267	133	4	nma	nma	PROPN
bjp-69267	133	5	and	and	CCONJ
bjp-69267	133	6	pdb	pdb	PROPN
bjp-69267	133	7	fields	field	NOUN
bjp-69267	133	8	,	,	PUNCT
bjp-69267	133	9	showing	show	VERB
bjp-69267	133	10	fluctuations	fluctuation	NOUN
bjp-69267	133	11	in	in	ADP
bjp-69267	133	12	complexes	complex	NOUN
bjp-69267	133	13	1kzn	1kzn	NOUN
bjp-69267	133	14	-	-	PUNCT
bjp-69267	133	15	pyr	pyr	NOUN
bjp-69267	133	16	,	,	PUNCT
bjp-69267	133	17	3hun	3hun	PROPN
bjp-69267	133	18	-	-	PUNCT
bjp-69267	133	19	pyr	pyr	NOUN
bjp-69267	133	20	,	,	PUNCT
bjp-69267	133	21	and	and	CCONJ
bjp-69267	133	22	7kcy	7kcy	NOUN
bjp-69267	133	23	-	-	PUNCT
bjp-69267	133	24	pyr	pyr	NOUN
bjp-69267	133	25	.	.	PUNCT
bjp-69267	134	1	eigenvalues	eigenvalue	NOUN
bjp-69267	134	2	and	and	CCONJ
bjp-69267	134	3	variance	variance	NOUN
bjp-69267	134	4	are	be	AUX
bjp-69267	134	5	inversely	inversely	ADV
bjp-69267	134	6	related	relate	VERB
bjp-69267	134	7	,	,	PUNCT
bjp-69267	134	8	with	with	ADP
bjp-69267	134	9	complex	complex	ADJ
bjp-69267	134	10	5tz1	5tz1	ADV
bjp-69267	134	11	-	-	PUNCT
bjp-69267	134	12	pyr	pyr	NOUN
bjp-69267	134	13	having	have	VERB
bjp-69267	134	14	the	the	DET
bjp-69267	134	15	lowest	low	ADJ
bjp-69267	134	16	eigenvalue	eigenvalue	NOUN
bjp-69267	134	17	.	.	PUNCT
bjp-69267	135	1	the	the	DET
bjp-69267	135	2	covariance	covariance	NOUN
bjp-69267	135	3	matrix	matrix	NOUN
bjp-69267	135	4	illustrated	illustrate	VERB
bjp-69267	135	5	correlations	correlation	NOUN
bjp-69267	135	6	between	between	ADP
bjp-69267	135	7	complex	complex	ADJ
bjp-69267	135	8	residues	residue	NOUN
bjp-69267	135	9	,	,	PUNCT
bjp-69267	135	10	with	with	ADP
bjp-69267	135	11	red	red	ADJ
bjp-69267	135	12	indicating	indicate	VERB
bjp-69267	135	13	strong	strong	ADJ
bjp-69267	135	14	correlations	correlation	NOUN
bjp-69267	135	15	,	,	PUNCT
bjp-69267	136	1	white	white	ADJ
bjp-69267	136	2	indicating	indicate	VERB
bjp-69267	136	3	uncorrelated	uncorrelated	ADJ
bjp-69267	136	4	movement	movement	NOUN
bjp-69267	136	5	,	,	PUNCT
bjp-69267	136	6	and	and	CCONJ
bjp-69267	136	7	blue	blue	ADJ
bjp-69267	136	8	indicating	indicate	VERB
bjp-69267	136	9	anti	anti	NOUN
bjp-69267	136	10	-	-	NOUN
bjp-69267	136	11	correlations	correlation	NOUN
bjp-69267	136	12	.	.	PUNCT
bjp-69267	136	13	elastic	elastic	ADJ
bjp-69267	136	14	network	network	NOUN
bjp-69267	136	15	protein	protein	NOUN
bjp-69267	136	16	maps	map	NOUN
bjp-69267	136	17	highlight	highlight	VERB
bjp-69267	136	18	associations	association	NOUN
bjp-69267	136	19	between	between	ADP
bjp-69267	136	20	atoms	atom	NOUN
bjp-69267	136	21	,	,	PUNCT
bjp-69267	136	22	with	with	ADP
bjp-69267	136	23	darker	dark	ADJ
bjp-69267	136	24	areas	area	NOUN
bjp-69267	136	25	representing	represent	VERB
bjp-69267	136	26	more	more	ADV
bjp-69267	136	27	rigid	rigid	ADJ
bjp-69267	136	28	parts	part	NOUN
bjp-69267	136	29	of	of	ADP
bjp-69267	136	30	the	the	DET
bjp-69267	136	31	molecule	molecule	NOUN
bjp-69267	136	32	.	.	PUNCT
bjp-69267	137	1	discussion	discussion	NOUN
bjp-69267	137	2	the	the	DET
bjp-69267	137	3	synthesis	synthesis	NOUN
bjp-69267	137	4	of	of	ADP
bjp-69267	137	5	5-(4-(dimethylamino)phenyl)-3	5-(4-(dimethylamino)phenyl)-3	PROPN
bjp-69267	137	6	-	-	PUNCT
bjp-69267	137	7	phenyl	phenyl	NOUN
bjp-69267	137	8	-4,5	-4,5	NOUN
bjp-69267	137	9	-	-	PUNCT
bjp-69267	137	10	dihydro-1h	dihydro-1h	NOUN
bjp-69267	137	11	-	-	PUNCT
bjp-69267	137	12	pyrazole-1	pyrazole-1	NOUN
bjp-69267	137	13	-	-	PUNCT
bjp-69267	137	14	carboxamide	carboxamide	NOUN
bjp-69267	137	15	closely	closely	ADV
bjp-69267	137	16	resem	resem	ADJ
bjp-69267	137	17	-bles	-ble	NOUN
bjp-69267	137	18	the	the	DET
bjp-69267	137	19	procedure	procedure	NOUN
bjp-69267	137	20	reported	report	VERB
bjp-69267	137	21	in	in	ADP
bjp-69267	137	22	the	the	DET
bjp-69267	137	23	previous	previous	ADJ
bjp-69267	137	24	study	study	NOUN
bjp-69267	137	25	by	by	ADP
bjp-69267	137	26	(	(	PUNCT
bjp-69267	137	27	sehmi	sehmi	PROPN
bjp-69267	137	28	et	et	PROPN
bjp-69267	137	29	al	al	PROPN
bjp-69267	137	30	.	.	PROPN
bjp-69267	137	31	,	,	PUNCT
bjp-69267	137	32	2020	2020	NUM
bjp-69267	137	33	)	)	PUNCT
bjp-69267	137	34	for	for	ADP
bjp-69267	137	35	the	the	DET
bjp-69267	137	36	formation	formation	NOUN
bjp-69267	137	37	of	of	ADP
bjp-69267	137	38	the	the	DET
bjp-69267	137	39	chalcone	chalcone	NOUN
bjp-69267	137	40	derivative	derivative	NOUN
bjp-69267	137	41	,	,	PUNCT
bjp-69267	137	42	with	with	ADP
bjp-69267	137	43	both	both	DET
bjp-69267	137	44	studies	study	NOUN
bjp-69267	137	45	employing	employ	VERB
bjp-69267	137	46	similar	similar	ADJ
bjp-69267	137	47	reactants	reactant	NOUN
bjp-69267	137	48	and	and	CCONJ
bjp-69267	137	49	basic	basic	ADJ
bjp-69267	137	50	conditions	condition	NOUN
bjp-69267	137	51	.	.	PUNCT
bjp-69267	138	1	however	however	ADV
bjp-69267	138	2	,	,	PUNCT
bjp-69267	138	3	this	this	DET
bjp-69267	138	4	study	study	NOUN
bjp-69267	138	5	notably	notably	ADV
bjp-69267	138	6	achieves	achieve	VERB
bjp-69267	138	7	a	a	DET
bjp-69267	138	8	respectable	respectable	ADJ
bjp-69267	138	9	77	77	NUM
bjp-69267	138	10	%	%	NOUN
bjp-69267	138	11	yield	yield	NOUN
bjp-69267	138	12	for	for	ADP
bjp-69267	138	13	the	the	DET
bjp-69267	138	14	final	final	ADJ
bjp-69267	138	15	compound	compound	NOUN
bjp-69267	138	16	,	,	PUNCT
bjp-69267	138	17	whereas	whereas	SCONJ
bjp-69267	138	18	the	the	DET
bjp-69267	138	19	yield	yield	NOUN
bjp-69267	138	20	in	in	ADP
bjp-69267	138	21	the	the	DET
bjp-69267	138	22	previous	previous	ADJ
bjp-69267	138	23	work	work	NOUN
bjp-69267	138	24	remains	remain	VERB
bjp-69267	138	25	unspecified	unspecified	ADJ
bjp-69267	138	26	.	.	PUNCT
bjp-69267	139	1	results	result	NOUN
bjp-69267	139	2	indicated	indicate	VERB
bjp-69267	139	3	varying	vary	VERB
bjp-69267	139	4	degrees	degree	NOUN
bjp-69267	139	5	of	of	ADP
bjp-69267	139	6	inhibition	inhibition	NOUN
bjp-69267	139	7	by	by	ADP
bjp-69267	139	8	pyrazoline	pyrazoline	NOUN
bjp-69267	139	9	carboxamide	carboxamide	NOUN
bjp-69267	139	10	at	at	ADP
bjp-69267	139	11	different	different	ADJ
bjp-69267	139	12	concentrations	concentration	NOUN
bjp-69267	139	13	.	.	PUNCT
bjp-69267	140	1	l.	l.	PROPN
bjp-69267	140	2	monocytogenes	monocytogenes	PROPN
bjp-69267	140	3	and	and	CCONJ
bjp-69267	140	4	c.	c.	NOUN
bjp-69267	140	5	albicans	albican	NOUN
bjp-69267	140	6	were	be	AUX
bjp-69267	140	7	more	more	ADV
bjp-69267	140	8	sensitive	sensitive	ADJ
bjp-69267	140	9	to	to	ADP
bjp-69267	140	10	pyrazoline	pyrazoline	NOUN
bjp-69267	140	11	carboxamide	carboxamide	NOUN
bjp-69267	140	12	compared	compare	VERB
bjp-69267	140	13	to	to	ADP
bjp-69267	140	14	e.	e.	PROPN
bjp-69267	140	15	coli	coli	PROPN
bjp-69267	140	16	,	,	PUNCT
bjp-69267	140	17	s.	s.	PROPN
bjp-69267	140	18	aureu	aureu	PROPN
bjp-69267	140	19	,	,	PUNCT
bjp-69267	140	20	and	and	CCONJ
bjp-69267	140	21	p.	p.	PROPN
bjp-69267	140	22	aeruginosa	aeruginosa	PROPN
bjp-69267	140	23	.	.	PUNCT
bjp-69267	141	1	gentamicin	gentamicin	PROPN
bjp-69267	141	2	exhibited	exhibit	VERB
bjp-69267	141	3	significant	significant	ADJ
bjp-69267	141	4	inhibition	inhibition	NOUN
bjp-69267	141	5	against	against	ADP
bjp-69267	141	6	e.	e.	PROPN
bjp-69267	141	7	coli	coli	PROPN
bjp-69267	141	8	and	and	CCONJ
bjp-69267	141	9	s.	s.	PROPN
bjp-69267	141	10	aureu	aureu	PROPN
bjp-69267	141	11	,	,	PUNCT
bjp-69267	141	12	while	while	SCONJ
bjp-69267	141	13	other	other	ADJ
bjp-69267	141	14	antibiotics	antibiotic	NOUN
bjp-69267	141	15	displayed	display	VERB
bjp-69267	141	16	moderate	moderate	ADJ
bjp-69267	141	17	to	to	ADP
bjp-69267	141	18	limited	limit	VERB
bjp-69267	141	19	efficacy	efficacy	NOUN
bjp-69267	141	20	.	.	PUNCT
bjp-69267	142	1	these	these	DET
bjp-69267	142	2	findings	finding	NOUN
bjp-69267	142	3	suggest	suggest	VERB
bjp-69267	142	4	that	that	SCONJ
bjp-69267	142	5	pyrazoline	pyrazoline	NOUN
bjp-69267	142	6	carboxamide	carboxamide	NOUN
bjp-69267	142	7	holds	hold	VERB
bjp-69267	142	8	promise	promise	NOUN
bjp-69267	142	9	as	as	ADP
bjp-69267	142	10	an	an	DET
bjp-69267	142	11	antimicrobial	antimicrobial	ADJ
bjp-69267	142	12	agent	agent	NOUN
bjp-69267	142	13	,	,	PUNCT
bjp-69267	142	14	especially	especially	ADV
bjp-69267	142	15	against	against	ADP
bjp-69267	142	16	l.	l.	PROPN
bjp-69267	142	17	monocytogenes	monocytogenes	PROPN
bjp-69267	142	18	and	and	CCONJ
bjp-69267	142	19	c.	c.	NOUN
bjp-69267	142	20	albicans	albican	NOUN
bjp-69267	142	21	.	.	PUNCT
bjp-69267	143	1	these	these	DET
bjp-69267	143	2	results	result	NOUN
bjp-69267	143	3	align	align	VERB
bjp-69267	143	4	with	with	ADP
bjp-69267	143	5	previous	previous	ADJ
bjp-69267	143	6	research	research	NOUN
bjp-69267	143	7	reported	report	VERB
bjp-69267	143	8	that	that	SCONJ
bjp-69267	143	9	several	several	ADJ
bjp-69267	143	10	drug	drug	NOUN
bjp-69267	143	11	-	-	PUNCT
bjp-69267	143	12	like	like	ADJ
bjp-69267	143	13	compounds	compound	NOUN
bjp-69267	143	14	including	include	VERB
bjp-69267	143	15	indazoles	indazole	NOUN
bjp-69267	143	16	,	,	PUNCT
bjp-69267	143	17	pyrazoles	pyrazole	NOUN
bjp-69267	143	18	,	,	PUNCT
bjp-69267	143	19	and	and	CCONJ
bjp-69267	143	20	pyrazolines	pyrazoline	NOUN
bjp-69267	143	21	as	as	ADP
bjp-69267	143	22	key	key	ADJ
bjp-69267	143	23	heterocyclic	heterocyclic	ADJ
bjp-69267	143	24	units	unit	NOUN
bjp-69267	143	25	,	,	PUNCT
bjp-69267	143	26	synthesized	synthesize	VERB
bjp-69267	143	27	in	in	ADP
bjp-69267	143	28	a	a	DET
bjp-69267	143	29	flowthrough	flowthrough	ADJ
bjp-69267	143	30	mode	mode	NOUN
bjp-69267	143	31	,	,	PUNCT
bjp-69267	143	32	were	be	AUX
bjp-69267	143	33	found	find	VERB
bjp-69267	143	34	to	to	PART
bjp-69267	143	35	possess	possess	VERB
bjp-69267	143	36	significant	significant	ADJ
bjp-69267	143	37	antibacterial	antibacterial	ADJ
bjp-69267	143	38	potency	potency	NOUN
bjp-69267	143	39	against	against	ADP
bjp-69267	143	40	clinical	clinical	ADJ
bjp-69267	143	41	and	and	CCONJ
bjp-69267	143	42	multi	multi	ADJ
bjp-69267	143	43	-	-	ADJ
bjp-69267	143	44	drug	drug	ADJ
bjp-69267	143	45	resistant	resistant	ADJ
bjp-69267	143	46	bacterial	bacterial	ADJ
bjp-69267	143	47	strains	strain	NOUN
bjp-69267	143	48	of	of	ADP
bjp-69267	143	49	the	the	DET
bjp-69267	143	50	genera	genera	NOUN
bjp-69267	143	51	staphylococcus	staphylococcus	NOUN
bjp-69267	143	52	and	and	CCONJ
bjp-69267	143	53	enterococcus	enterococcus	NOUN
bjp-69267	143	54	(	(	PUNCT
bjp-69267	143	55	burke	burke	PROPN
bjp-69267	143	56	et	et	PROPN
bjp-69267	143	57	al	al	PROPN
bjp-69267	143	58	.	.	PROPN
bjp-69267	143	59	,	,	PUNCT
bjp-69267	143	60	2023	2023	NUM
bjp-69267	143	61	)	)	PUNCT
bjp-69267	143	62	.	.	PUNCT
bjp-69267	144	1	additionally	additionally	ADV
bjp-69267	144	2	,	,	PUNCT
bjp-69267	144	3	investigated	investigate	VERB
bjp-69267	144	4	the	the	DET
bjp-69267	144	5	antibacterial	antibacterial	ADJ
bjp-69267	144	6	activity	activity	NOUN
bjp-69267	144	7	against	against	ADP
bjp-69267	144	8	grampositive	grampositive	NOUN
bjp-69267	144	9	and	and	CCONJ
bjp-69267	144	10	gram	gram	NOUN
bjp-69267	144	11	-	-	PUNCT
bjp-69267	144	12	negative	negative	ADJ
bjp-69267	144	13	bacteria	bacteria	NOUN
bjp-69267	144	14	of	of	ADP
bjp-69267	144	15	new	new	ADJ
bjp-69267	144	16	series	series	NOUN
bjp-69267	144	17	of	of	ADP
bjp-69267	144	18	schiff	schiff	NOUN
bjp-69267	144	19	-	-	PUNCT
bjp-69267	144	20	based	base	VERB
bjp-69267	144	21	thiazole	thiazole	NOUN
bjp-69267	144	22	-	-	PUNCT
bjp-69267	144	23	pyrazoline	pyrazoline	NOUN
bjp-69267	144	24	hybrids	hybrid	NOUN
bjp-69267	144	25	using	use	VERB
bjp-69267	144	26	zno	zno	NOUN
bjp-69267	144	27	nanoparticles	nanoparticle	NOUN
bjp-69267	144	28	with	with	ADP
bjp-69267	144	29	a	a	DET
bjp-69267	144	30	more	more	ADV
bjp-69267	144	31	environmentally	environmentally	ADV
bjp-69267	144	32	friendly	friendly	ADJ
bjp-69267	144	33	and	and	CCONJ
bjp-69267	144	34	effective	effective	ADJ
bjp-69267	144	35	approach	approach	NOUN
bjp-69267	144	36	,	,	PUNCT
bjp-69267	144	37	showing	show	VERB
bjp-69267	144	38	better	well	ADJ
bjp-69267	144	39	activity	activity	NOUN
bjp-69267	144	40	against	against	ADP
bjp-69267	144	41	p.	p.	NOUN
bjp-69267	144	42	aeruginosa	aeruginosa	PROPN
bjp-69267	144	43	and	and	CCONJ
bjp-69267	144	44	e.	e.	PROPN
bjp-69267	144	45	coli	coli	PROPN
bjp-69267	144	46	compared	compare	VERB
bjp-69267	144	47	to	to	ADP
bjp-69267	144	48	amoxicillin	amoxicillin	PROPN
bjp-69267	144	49	(	(	PUNCT
bjp-69267	144	50	14.3	14.3	NUM
bjp-69267	144	51	±	±	NUM
bjp-69267	144	52	2.5	2.5	NUM
bjp-69267	144	53	and	and	CCONJ
bjp-69267	144	54	14.7	14.7	NUM
bjp-69267	144	55	±	±	NUM
bjp-69267	144	56	0.6	0.6	NUM
bjp-69267	144	57	mm	mm	NOUN
bjp-69267	144	58	respectively	respectively	ADV
bjp-69267	144	59	;	;	PUNCT
bjp-69267	144	60	zelelew	zelelew	PROPN
bjp-69267	144	61	et	et	PROPN
bjp-69267	144	62	al	al	PROPN
bjp-69267	144	63	.	.	PROPN
bjp-69267	144	64	,	,	PUNCT
bjp-69267	144	65	2022	2022	NUM
bjp-69267	144	66	)	)	PUNCT
bjp-69267	144	67	.	.	PUNCT
bjp-69267	145	1	a	a	DET
bjp-69267	145	2	study	study	NOUN
bjp-69267	145	3	on	on	ADP
bjp-69267	145	4	the	the	DET
bjp-69267	145	5	in	in	ADV
bjp-69267	145	6	vitro	vitro	X
bjp-69267	145	7	antibacterial	antibacterial	ADJ
bjp-69267	145	8	activity	activity	NOUN
bjp-69267	145	9	of	of	ADP
bjp-69267	145	10	the	the	DET
bjp-69267	145	11	synthesized	synthesize	VERB
bjp-69267	145	12	[	[	X
bjp-69267	145	13	5-(furan-2	5-(furan-2	NUM
bjp-69267	145	14	-	-	PUNCT
bjp-69267	145	15	yl)-phenyl]-4,5	yl)-phenyl]-4,5	NUM
bjp-69267	145	16	-	-	PUNCT
bjp-69267	145	17	carbothioamide	carbothioamide	NOUN
bjp-69267	145	18	-pyrazolines	-pyrazoline	NOUN
bjp-69267	145	19	was	be	AUX
bjp-69267	145	20	evaluated	evaluate	VERB
bjp-69267	145	21	by	by	ADP
bjp-69267	145	22	the	the	DET
bjp-69267	145	23	disk	disk	NOUN
bjp-69267	145	24	diffusion	diffusion	NOUN
bjp-69267	145	25	test	test	NOUN
bjp-69267	145	26	,	,	PUNCT
bjp-69267	145	27	and	and	CCONJ
bjp-69267	145	28	then	then	ADV
bjp-69267	145	29	by	by	ADP
bjp-69267	145	30	the	the	DET
bjp-69267	145	31	minimum	minimum	ADJ
bjp-69267	145	32	inhibitory	inhibitory	ADJ
bjp-69267	145	33	concentration	concentration	NOUN
bjp-69267	145	34	of	of	ADP
bjp-69267	145	35	two	two	NUM
bjp-69267	145	36	gram	gram	NOUN
bjp-69267	145	37	-	-	PUNCT
bjp-69267	145	38	positive	positive	ADJ
bjp-69267	145	39	and	and	CCONJ
bjp-69267	145	40	two	two	NUM
bjp-69267	145	41	gram	gram	ADJ
bjp-69267	145	42	-	-	PUNCT
bjp-69267	145	43	negative	negative	ADJ
bjp-69267	145	44	bacteria	bacteria	NOUN
bjp-69267	145	45	such	such	ADJ
bjp-69267	145	46	as	as	ADP
bjp-69267	145	47	aeromonas	aeromonas	PROPN
bjp-69267	145	48	hydrophila	hydrophila	PROPN
bjp-69267	145	49	,	,	PUNCT
bjp-69267	145	50	yersinia	yersinia	PROPN
bjp-69267	145	51	enterocolitica	enterocolitica	PROPN
bjp-69267	145	52	,	,	PUNCT
bjp-69267	145	53	l.	l.	PROPN
bjp-69267	145	54	monocytogenes	monocytogenes	PROPN
bjp-69267	145	55	and	and	CCONJ
bjp-69267	145	56	s.	s.	PROPN
bjp-69267	145	57	aureus	aureus	PROPN
bjp-69267	145	58	,	,	PUNCT
bjp-69267	145	59	revealed	reveal	VERB
bjp-69267	145	60	a	a	DET
bjp-69267	145	61	promising	promising	ADJ
bjp-69267	145	62	antibacterial	antibacterial	ADJ
bjp-69267	145	63	activity	activity	NOUN
bjp-69267	145	64	compared	compare	VERB
bjp-69267	145	65	to	to	ADP
bjp-69267	145	66	gentamicin	gentamicin	NOUN
bjp-69267	145	67	and	and	CCONJ
bjp-69267	145	68	tetracycline	tetracycline	PROPN
bjp-69267	145	69	(	(	PUNCT
bjp-69267	145	70	rani	rani	PROPN
bjp-69267	145	71	et	et	PROPN
bjp-69267	145	72	al	al	PROPN
bjp-69267	145	73	.	.	PROPN
bjp-69267	145	74	,	,	PUNCT
bjp-69267	145	75	2012	2012	NUM
bjp-69267	145	76	)	)	PUNCT
bjp-69267	145	77	.	.	PUNCT
bjp-69267	146	1	moreover	moreover	ADV
bjp-69267	146	2	,	,	PUNCT
bjp-69267	146	3	the	the	DET
bjp-69267	146	4	synthesized	synthesize	VERB
bjp-69267	146	5	pyrazoline	pyrazoline	NOUN
bjp-69267	146	6	carboxamide	carboxamide	NOUN
bjp-69267	146	7	compound	compound	NOUN
bjp-69267	146	8	,	,	PUNCT
bjp-69267	146	9	holds	hold	VERB
bjp-69267	146	10	promise	promise	NOUN
bjp-69267	146	11	for	for	ADP
bjp-69267	146	12	drug	drug	NOUN
bjp-69267	146	13	development	development	NOUN
bjp-69267	146	14	due	due	ADP
bjp-69267	146	15	to	to	ADP
bjp-69267	146	16	its	its	PRON
bjp-69267	146	17	favorable	favorable	ADJ
bjp-69267	146	18	physicochemical	physicochemical	ADJ
bjp-69267	146	19	attributes	attribute	NOUN
bjp-69267	146	20	,	,	PUNCT
bjp-69267	146	21	including	include	VERB
bjp-69267	146	22	molecular	molecular	ADJ
bjp-69267	146	23	weight	weight	NOUN
bjp-69267	146	24	,	,	PUNCT
bjp-69267	146	25	composition	composition	NOUN
bjp-69267	146	26	,	,	PUNCT
bjp-69267	146	27	and	and	CCONJ
bjp-69267	146	28	aromaticity	aromaticity	NOUN
bjp-69267	146	29	,	,	PUNCT
bjp-69267	146	30	positioning	position	VERB
bjp-69267	146	31	it	it	PRON
bjp-69267	146	32	within	within	ADP
bjp-69267	146	33	a	a	DET
bjp-69267	146	34	suitable	suitable	ADJ
bjp-69267	146	35	molecular	molecular	ADJ
bjp-69267	146	36	framework	framework	NOUN
bjp-69267	146	37	(	(	PUNCT
bjp-69267	146	38	ahmad	ahmad	PROPN
bjp-69267	146	39	et	et	PROPN
bjp-69267	146	40	al	al	PROPN
bjp-69267	146	41	.	.	PROPN
bjp-69267	146	42	,	,	PUNCT
bjp-69267	146	43	2023	2023	NUM
bjp-69267	146	44	)	)	PUNCT
bjp-69267	146	45	.	.	PUNCT
bjp-69267	147	1	its	its	PRON
bjp-69267	147	2	moderate	moderate	ADJ
bjp-69267	147	3	lipophilicity	lipophilicity	NOUN
bjp-69267	147	4	suggests	suggest	VERB
bjp-69267	147	5	an	an	DET
bjp-69267	147	6	ability	ability	NOUN
bjp-69267	147	7	to	to	PART
bjp-69267	147	8	traverse	traverse	VERB
bjp-69267	147	9	both	both	CCONJ
bjp-69267	147	10	aqueous	aqueous	ADJ
bjp-69267	147	11	and	and	CCONJ
bjp-69267	147	12	lipid	lipid	NOUN
bjp-69267	147	13	environments	environment	NOUN
bjp-69267	147	14	,	,	PUNCT
bjp-69267	147	15	vital	vital	ADJ
bjp-69267	147	16	for	for	ADP
bjp-69267	147	17	effective	effective	ADJ
bjp-69267	147	18	distribution	distribution	NOUN
bjp-69267	147	19	and	and	CCONJ
bjp-69267	147	20	membrane	membrane	NOUN
bjp-69267	147	21	permeation	permeation	NOUN
bjp-69267	147	22	(	(	PUNCT
bjp-69267	147	23	lipinski	lipinski	PROPN
bjp-69267	147	24	,	,	PUNCT
bjp-69267	147	25	2001	2001	NUM
bjp-69267	147	26	)	)	PUNCT
bjp-69267	147	27	.	.	PUNCT
bjp-69267	148	1	additionally	additionally	ADV
bjp-69267	148	2	,	,	PUNCT
bjp-69267	148	3	the	the	DET
bjp-69267	148	4	compound	compound	NOUN
bjp-69267	148	5	demonstrates	demonstrate	VERB
bjp-69267	148	6	high	high	ADJ
bjp-69267	148	7	gastrointestinal	gastrointestinal	ADJ
bjp-69267	148	8	absorption	absorption	NOUN
bjp-69267	148	9	potential	potential	NOUN
bjp-69267	148	10	and	and	CCONJ
bjp-69267	148	11	blood	blood	NOUN
bjp-69267	148	12	-	-	PUNCT
bjp-69267	148	13	brain	brain	NOUN
bjp-69267	148	14	barrier	barrier	NOUN
bjp-69267	148	15	permeability	permeability	NOUN
bjp-69267	148	16	,	,	PUNCT
bjp-69267	148	17	signifying	signify	VERB
bjp-69267	148	18	its	its	PRON
bjp-69267	148	19	capacity	capacity	NOUN
bjp-69267	148	20	to	to	PART
bjp-69267	148	21	enter	enter	VERB
bjp-69267	148	22	the	the	DET
bjp-69267	148	23	systemic	systemic	ADJ
bjp-69267	148	24	circulation	circulation	NOUN
bjp-69267	148	25	and	and	CCONJ
bjp-69267	148	26	potentially	potentially	ADV
bjp-69267	148	27	target	target	VERB
bjp-69267	148	28	the	the	DET
bjp-69267	148	29	central	central	ADJ
bjp-69267	148	30	nervous	nervous	ADJ
bjp-69267	148	31	system	system	NOUN
bjp-69267	148	32	(	(	PUNCT
bjp-69267	148	33	pardridge	pardridge	VERB
bjp-69267	148	34	,	,	PUNCT
bjp-69267	148	35	2012	2012	NUM
bjp-69267	148	36	)	)	PUNCT
bjp-69267	148	37	.	.	PUNCT
bjp-69267	149	1	while	while	SCONJ
bjp-69267	149	2	its	its	PRON
bjp-69267	149	3	adherence	adherence	NOUN
bjp-69267	149	4	to	to	ADP
bjp-69267	149	5	drug	drug	NOUN
bjp-69267	149	6	-	-	PUNCT
bjp-69267	149	7	likeness	likeness	NOUN
bjp-69267	149	8	criteria	criterion	NOUN
bjp-69267	149	9	is	be	AUX
bjp-69267	149	10	encouraging	encouraging	ADJ
bjp-69267	149	11	(	(	PUNCT
bjp-69267	149	12	lipinski	lipinski	PROPN
bjp-69267	149	13	,	,	PUNCT
bjp-69267	149	14	2001	2001	NUM
bjp-69267	149	15	)	)	PUNCT
bjp-69267	149	16	,	,	PUNCT
bjp-69267	149	17	the	the	DET
bjp-69267	149	18	presence	presence	NOUN
bjp-69267	149	19	of	of	ADP
bjp-69267	149	20	potentially	potentially	ADV
bjp-69267	149	21	toxic	toxic	ADJ
bjp-69267	149	22	substructures	substructure	NOUN
bjp-69267	149	23	necessitates	necessitate	VERB
bjp-69267	149	24	thorough	thorough	ADJ
bjp-69267	149	25	safety	safety	NOUN
bjp-69267	149	26	evaluation	evaluation	NOUN
bjp-69267	149	27	before	before	ADP
bjp-69267	149	28	considering	consider	VERB
bjp-69267	149	29	it	it	PRON
bjp-69267	149	30	for	for	ADP
bjp-69267	149	31	clinical	clinical	ADJ
bjp-69267	149	32	use	use	NOUN
bjp-69267	149	33	(	(	PUNCT
bjp-69267	149	34	baell	baell	NOUN
bjp-69267	149	35	and	and	CCONJ
bjp-69267	149	36	holloway	holloway	PROPN
bjp-69267	149	37	,	,	PUNCT
bjp-69267	149	38	2010	2010	NUM
bjp-69267	149	39	)	)	PUNCT
bjp-69267	149	40	.	.	PUNCT
bjp-69267	150	1	these	these	DET
bjp-69267	150	2	findings	finding	NOUN
bjp-69267	150	3	underscore	underscore	VERB
bjp-69267	150	4	the	the	DET
bjp-69267	150	5	compound	compound	NOUN
bjp-69267	150	6	's	's	PART
bjp-69267	150	7	potential	potential	NOUN
bjp-69267	150	8	as	as	ADP
bjp-69267	150	9	a	a	DET
bjp-69267	150	10	therapeutic	therapeutic	ADJ
bjp-69267	150	11	candidate	candidate	NOUN
bjp-69267	150	12	,	,	PUNCT
bjp-69267	150	13	but	but	CCONJ
bjp-69267	150	14	further	further	ADJ
bjp-69267	150	15	scrutiny	scrutiny	NOUN
bjp-69267	150	16	and	and	CCONJ
bjp-69267	150	17	toxicity	toxicity	NOUN
bjp-69267	150	18	assessments	assessment	NOUN
bjp-69267	150	19	,	,	PUNCT
bjp-69267	150	20	as	as	SCONJ
bjp-69267	150	21	performed	perform	VERB
bjp-69267	150	22	using	use	VERB
bjp-69267	150	23	the	the	DET
bjp-69267	150	24	emoltox	emoltox	ADJ
bjp-69267	150	25	web	web	NOUN
bjp-69267	150	26	tool	tool	NOUN
bjp-69267	150	27	,	,	PUNCT
bjp-69267	150	28	are	be	AUX
bjp-69267	150	29	imperative	imperative	ADJ
bjp-69267	150	30	to	to	PART
bjp-69267	150	31	ensure	ensure	VERB
bjp-69267	150	32	both	both	PRON
bjp-69267	150	33	its	its	PRON
bjp-69267	150	34	efficacy	efficacy	NOUN
bjp-69267	150	35	and	and	CCONJ
bjp-69267	150	36	safety	safety	NOUN
bjp-69267	150	37	in	in	ADP
bjp-69267	150	38	drug	drug	NOUN
bjp-69267	150	39	development	development	NOUN
bjp-69267	150	40	(	(	PUNCT
bjp-69267	150	41	ji	ji	X
bjp-69267	150	42	et	et	PROPN
bjp-69267	150	43	al	al	PROPN
bjp-69267	150	44	.	.	PROPN
bjp-69267	150	45	,	,	PUNCT
bjp-69267	150	46	2018	2018	NUM
bjp-69267	150	47	)	)	PUNCT
bjp-69267	150	48	.	.	PUNCT
bjp-69267	151	1	furthermore	furthermore	ADV
bjp-69267	151	2	,	,	PUNCT
bjp-69267	151	3	a	a	DET
bjp-69267	151	4	comprehensive	comprehensive	ADJ
bjp-69267	151	5	analysis	analysis	NOUN
bjp-69267	151	6	of	of	ADP
bjp-69267	151	7	the	the	DET
bjp-69267	151	8	binding	bind	VERB
bjp-69267	151	9	interactions	interaction	NOUN
bjp-69267	151	10	between	between	ADP
bjp-69267	151	11	the	the	DET
bjp-69267	151	12	new	new	ADJ
bjp-69267	151	13	pyrazoline	pyrazoline	NOUN
bjp-69267	151	14	compound	compound	NOUN
bjp-69267	151	15	and	and	CCONJ
bjp-69267	151	16	various	various	ADJ
bjp-69267	151	17	antimicrobial	antimicrobial	ADJ
bjp-69267	151	18	target	target	NOUN
bjp-69267	151	19	proteins	protein	NOUN
bjp-69267	151	20	has	have	AUX
bjp-69267	151	21	been	be	AUX
bjp-69267	151	22	investigated	investigate	VERB
bjp-69267	151	23	.	.	PUNCT
bjp-69267	152	1	the	the	DET
bjp-69267	152	2	study	study	NOUN
bjp-69267	152	3	assesses	assess	VERB
bjp-69267	152	4	the	the	DET
bjp-69267	152	5	strength	strength	NOUN
bjp-69267	152	6	of	of	ADP
bjp-69267	152	7	these	these	DET
bjp-69267	152	8	interactions	interaction	NOUN
bjp-69267	152	9	through	through	ADP
bjp-69267	152	10	estimated	estimate	VERB
bjp-69267	152	11	binding	binding	ADJ
bjp-69267	152	12	free	free	ADJ
bjp-69267	152	13	energy	energy	NOUN
bjp-69267	152	14	,	,	PUNCT
bjp-69267	152	15	highlighting	highlight	VERB
bjp-69267	152	16	the	the	DET
bjp-69267	152	17	binding	bind	VERB
bjp-69267	152	18	affinities	affinity	NOUN
bjp-69267	152	19	of	of	ADP
bjp-69267	152	20	pyr	pyr	NOUN
bjp-69267	152	21	compared	compare	VERB
bjp-69267	152	22	to	to	ADP
bjp-69267	152	23	established	establish	VERB
bjp-69267	152	24	standard	standard	ADJ
bjp-69267	152	25	inhibitors	inhibitor	NOUN
bjp-69267	152	26	.	.	PUNCT
bjp-69267	153	1	the	the	DET
bjp-69267	153	2	results	result	NOUN
bjp-69267	153	3	reveal	reveal	VERB
bjp-69267	153	4	that	that	SCONJ
bjp-69267	153	5	pyr	pyr	NOUN
bjp-69267	153	6	exhibits	exhibit	VERB
bjp-69267	153	7	variable	variable	ADJ
bjp-69267	153	8	binding	bind	VERB
bjp-69267	153	9	affinities	affinity	NOUN
bjp-69267	153	10	for	for	ADP
bjp-69267	153	11	different	different	ADJ
bjp-69267	153	12	proteins	protein	NOUN
bjp-69267	153	13	,	,	PUNCT
bjp-69267	153	14	with	with	ADP
bjp-69267	153	15	specific	specific	ADJ
bjp-69267	153	16	amino	amino	NOUN
bjp-69267	153	17	acid	acid	NOUN
bjp-69267	153	18	residues	residue	NOUN
bjp-69267	153	19	involved	involve	VERB
bjp-69267	153	20	in	in	ADP
bjp-69267	153	21	these	these	DET
bjp-69267	153	22	interactions	interaction	NOUN
bjp-69267	153	23	.	.	PUNCT
bjp-69267	154	1	notably	notably	ADV
bjp-69267	154	2	,	,	PUNCT
bjp-69267	154	3	pyr	pyr	NOUN
bjp-69267	154	4	exhibits	exhibit	VERB
bjp-69267	154	5	high	high	ADJ
bjp-69267	154	6	binding	bind	VERB
bjp-69267	154	7	affinity	affinity	NOUN
bjp-69267	154	8	to	to	ADP
bjp-69267	154	9	certain	certain	ADJ
bjp-69267	154	10	proteins	protein	NOUN
bjp-69267	154	11	,	,	PUNCT
bjp-69267	154	12	such	such	ADJ
bjp-69267	154	13	as	as	ADP
bjp-69267	154	14	-8.4	-8.4	X
bjp-69267	154	15	kcal	kcal	NOUN
bjp-69267	154	16	/	/	SYM
bjp-69267	154	17	mol	mol	PROPN
bjp-69267	154	18	for	for	ADP
bjp-69267	154	19	pdb	pdb	PROPN
bjp-69267	154	20	i	i	PROPN
bjp-69267	154	21	d	d	PROPN
bjp-69267	154	22	5tz1	5tz1	NUM
bjp-69267	154	23	.	.	PUNCT
bjp-69267	155	1	these	these	DET
bjp-69267	155	2	results	result	NOUN
bjp-69267	155	3	highlight	highlight	VERB
bjp-69267	155	4	the	the	DET
bjp-69267	155	5	complex	complex	ADJ
bjp-69267	155	6	and	and	CCONJ
bjp-69267	155	7	contextual	contextual	ADJ
bjp-69267	155	8	nature	nature	NOUN
bjp-69267	155	9	of	of	ADP
bjp-69267	155	10	pyr	pyr	NOUN
bjp-69267	155	11	's	's	PART
bjp-69267	155	12	interactions	interaction	NOUN
bjp-69267	155	13	with	with	ADP
bjp-69267	155	14	antimicrobial	antimicrobial	ADJ
bjp-69267	155	15	target	target	NOUN
bjp-69267	155	16	proteins	protein	NOUN
bjp-69267	155	17	,	,	PUNCT
bjp-69267	155	18	providing	provide	VERB
bjp-69267	155	19	valuable	valuable	ADJ
bjp-69267	155	20	insights	insight	NOUN
bjp-69267	155	21	for	for	ADP
bjp-69267	155	22	drug	drug	NOUN
bjp-69267	155	23	design	design	NOUN
bjp-69267	155	24	and	and	CCONJ
bjp-69267	155	25	optimization	optimization	NOUN
bjp-69267	155	26	in	in	ADP
bjp-69267	155	27	the	the	DET
bjp-69267	155	28	search	search	NOUN
bjp-69267	155	29	for	for	ADP
bjp-69267	155	30	improved	improved	ADJ
bjp-69267	155	31	antimicrobial	antimicrobial	ADJ
bjp-69267	155	32	effects	effect	NOUN
bjp-69267	155	33	(	(	PUNCT
bjp-69267	155	34	rossiter	rossiter	NOUN
bjp-69267	155	35	et	et	PROPN
bjp-69267	155	36	al	al	PROPN
bjp-69267	155	37	.	.	PROPN
bjp-69267	155	38	,	,	PUNCT
bjp-69267	155	39	2017	2017	NUM
bjp-69267	155	40	,	,	PUNCT
bjp-69267	155	41	kleandrova	kleandrova	PROPN
bjp-69267	155	42	and	and	CCONJ
bjp-69267	155	43	speck	speck	NOUN
bjp-69267	155	44	-	-	PUNCT
bjp-69267	155	45	planche	planche	NOUN
bjp-69267	155	46	,	,	PUNCT
bjp-69267	155	47	2020	2020	NUM
bjp-69267	155	48	)	)	PUNCT
bjp-69267	155	49	.	.	PUNCT
bjp-69267	156	1	finally	finally	ADV
bjp-69267	156	2	,	,	PUNCT
bjp-69267	156	3	the	the	DET
bjp-69267	156	4	bangladesh	bangladesh	NOUN
bjp-69267	156	5	j	j	PROPN
bjp-69267	156	6	pharmacol	pharmacol	PROPN
bjp-69267	156	7	2023	2023	NUM
bjp-69267	156	8	;	;	PUNCT
bjp-69267	156	9	18	18	NUM
bjp-69267	156	10	:	:	SYM
bjp-69267	156	11	152	152	NUM
bjp-69267	156	12	-	-	SYM
bjp-69267	156	13	161	161	NUM
bjp-69267	156	14	159	159	NUM
bjp-69267	156	15	results	result	NOUN
bjp-69267	156	16	of	of	ADP
bjp-69267	156	17	the	the	DET
bjp-69267	156	18	imods	imod	NOUN
bjp-69267	156	19	analysis	analysis	NOUN
bjp-69267	156	20	encompassing	encompass	VERB
bjp-69267	156	21	deformability	deformability	NOUN
bjp-69267	156	22	,	,	PUNCT
bjp-69267	156	23	factor	factor	NOUN
bjp-69267	156	24	b	b	NOUN
bjp-69267	156	25	,	,	PUNCT
bjp-69267	156	26	eigenvalues	eigenvalue	NOUN
bjp-69267	156	27	,	,	PUNCT
bjp-69267	156	28	variance	variance	NOUN
bjp-69267	156	29	map	map	NOUN
bjp-69267	156	30	,	,	PUNCT
bjp-69267	156	31	correlation	correlation	NOUN
bjp-69267	156	32	matrix	matrix	NOUN
bjp-69267	156	33	,	,	PUNCT
bjp-69267	156	34	and	and	CCONJ
bjp-69267	156	35	elastic	elastic	ADJ
bjp-69267	156	36	network	network	NOUN
bjp-69267	156	37	model	model	NOUN
bjp-69267	156	38	collectively	collectively	ADV
bjp-69267	156	39	provide	provide	VERB
bjp-69267	156	40	a	a	DET
bjp-69267	156	41	nuanced	nuanced	ADJ
bjp-69267	156	42	view	view	NOUN
bjp-69267	156	43	of	of	ADP
bjp-69267	156	44	the	the	DET
bjp-69267	156	45	structural	structural	ADJ
bjp-69267	156	46	dynamics	dynamic	NOUN
bjp-69267	156	47	of	of	ADP
bjp-69267	156	48	a	a	DET
bjp-69267	156	49	biological	biological	ADJ
bjp-69267	156	50	macromolecule	macromolecule	NOUN
bjp-69267	156	51	(	(	PUNCT
bjp-69267	156	52	lópez	lópez	NOUN
bjp-69267	156	53	-	-	PUNCT
bjp-69267	156	54	blanco	blanco	PROPN
bjp-69267	156	55	et	et	PROPN
bjp-69267	156	56	al	al	PROPN
bjp-69267	156	57	.	.	PROPN
bjp-69267	156	58	,	,	PUNCT
bjp-69267	156	59	2014	2014	NUM
bjp-69267	156	60	)	)	PUNCT
bjp-69267	156	61	.	.	PUNCT
bjp-69267	157	1	deformability	deformability	NOUN
bjp-69267	157	2	values	value	NOUN
bjp-69267	157	3	indicate	indicate	VERB
bjp-69267	157	4	regions	region	NOUN
bjp-69267	157	5	prone	prone	ADJ
bjp-69267	157	6	to	to	ADP
bjp-69267	157	7	flexibility	flexibility	NOUN
bjp-69267	157	8	,	,	PUNCT
bjp-69267	157	9	often	often	ADV
bjp-69267	157	10	associated	associate	VERB
bjp-69267	157	11	with	with	ADP
bjp-69267	157	12	vital	vital	ADJ
bjp-69267	157	13	functional	functional	ADJ
bjp-69267	157	14	sites	site	NOUN
bjp-69267	157	15	.	.	PUNCT
bjp-69267	158	1	b	b	X
bjp-69267	158	2	-	-	PUNCT
bjp-69267	158	3	factors	factor	NOUN
bjp-69267	158	4	reveal	reveal	VERB
bjp-69267	158	5	the	the	DET
bjp-69267	158	6	extent	extent	NOUN
bjp-69267	158	7	of	of	ADP
bjp-69267	158	8	atomic	atomic	ADJ
bjp-69267	158	9	thermal	thermal	ADJ
bjp-69267	158	10	vibrations	vibration	NOUN
bjp-69267	158	11	,	,	PUNCT
bjp-69267	158	12	highlighting	highlight	VERB
bjp-69267	158	13	regions	region	NOUN
bjp-69267	158	14	where	where	SCONJ
bjp-69267	158	15	mobility	mobility	NOUN
bjp-69267	158	16	is	be	AUX
bjp-69267	158	17	pronounced	pronounce	VERB
bjp-69267	158	18	(	(	PUNCT
bjp-69267	158	19	sun	sun	PROPN
bjp-69267	158	20	et	et	PROPN
bjp-69267	158	21	al	al	PROPN
bjp-69267	158	22	.	.	PROPN
bjp-69267	158	23	,	,	PUNCT
bjp-69267	158	24	2019	2019	NUM
bjp-69267	158	25	)	)	PUNCT
bjp-69267	158	26	.	.	PUNCT
bjp-69267	159	1	eigenvalues	eigenvalue	VERB
bjp-69267	159	2	give	give	VERB
bjp-69267	159	3	insight	insight	NOUN
bjp-69267	159	4	into	into	ADP
bjp-69267	159	5	vibrational	vibrational	ADJ
bjp-69267	159	6	modes	mode	NOUN
bjp-69267	159	7	,	,	PUNCT
bjp-69267	159	8	emphasizing	emphasize	VERB
bjp-69267	159	9	the	the	DET
bjp-69267	159	10	rigidity	rigidity	NOUN
bjp-69267	159	11	or	or	CCONJ
bjp-69267	159	12	flexibility	flexibility	NOUN
bjp-69267	159	13	of	of	ADP
bjp-69267	159	14	the	the	DET
bjp-69267	159	15	molecule	molecule	NOUN
bjp-69267	159	16	.	.	PUNCT
bjp-69267	160	1	variance	variance	NOUN
bjp-69267	160	2	maps	map	NOUN
bjp-69267	160	3	graphically	graphically	ADV
bjp-69267	160	4	describe	describe	VERB
bjp-69267	160	5	regions	region	NOUN
bjp-69267	160	6	with	with	ADP
bjp-69267	160	7	high	high	ADJ
bjp-69267	160	8	or	or	CCONJ
bjp-69267	160	9	low	low	ADJ
bjp-69267	160	10	atomic	atomic	ADJ
bjp-69267	160	11	fluctuations	fluctuation	NOUN
bjp-69267	160	12	,	,	PUNCT
bjp-69267	160	13	providing	provide	VERB
bjp-69267	160	14	clues	clue	NOUN
bjp-69267	160	15	about	about	ADP
bjp-69267	160	16	crucial	crucial	ADJ
bjp-69267	160	17	dynamic	dynamic	ADJ
bjp-69267	160	18	areas	area	NOUN
bjp-69267	160	19	(	(	PUNCT
bjp-69267	160	20	mishra	mishra	PROPN
bjp-69267	160	21	and	and	CCONJ
bjp-69267	160	22	jernigan	jernigan	PROPN
bjp-69267	160	23	,	,	PUNCT
bjp-69267	160	24	2018	2018	NUM
bjp-69267	160	25	)	)	PUNCT
bjp-69267	160	26	.	.	PUNCT
bjp-69267	161	1	the	the	DET
bjp-69267	161	2	correlation	correlation	NOUN
bjp-69267	161	3	matrix	matrix	NOUN
bjp-69267	161	4	reveals	reveal	VERB
bjp-69267	161	5	functional	functional	ADJ
bjp-69267	161	6	interactions	interaction	NOUN
bjp-69267	161	7	and	and	CCONJ
bjp-69267	161	8	structural	structural	ADJ
bjp-69267	161	9	connections	connection	NOUN
bjp-69267	161	10	,	,	PUNCT
bjp-69267	161	11	while	while	SCONJ
bjp-69267	161	12	the	the	DET
bjp-69267	161	13	elastic	elastic	ADJ
bjp-69267	161	14	network	network	NOUN
bjp-69267	161	15	model	model	NOUN
bjp-69267	161	16	simplifies	simplifie	NOUN
bjp-69267	161	17	interactions	interaction	NOUN
bjp-69267	161	18	to	to	PART
bjp-69267	161	19	predict	predict	VERB
bjp-69267	161	20	collective	collective	ADJ
bjp-69267	161	21	movements	movement	NOUN
bjp-69267	161	22	(	(	PUNCT
bjp-69267	161	23	liu	liu	PROPN
bjp-69267	161	24	,	,	PUNCT
bjp-69267	161	25	2022	2022	NUM
bjp-69267	161	26	)	)	PUNCT
bjp-69267	161	27	.	.	PUNCT
bjp-69267	162	1	interpreting	interpret	VERB
bjp-69267	162	2	these	these	DET
bjp-69267	162	3	results	result	NOUN
bjp-69267	162	4	not	not	PART
bjp-69267	162	5	only	only	ADV
bjp-69267	162	6	helps	helps	AUX
bjp-69267	162	7	understand	understand	VERB
bjp-69267	162	8	the	the	DET
bjp-69267	162	9	intrinsic	intrinsic	ADJ
bjp-69267	162	10	behavior	behavior	NOUN
bjp-69267	162	11	of	of	ADP
bjp-69267	162	12	the	the	DET
bjp-69267	162	13	molecule	molecule	NOUN
bjp-69267	162	14	but	but	CCONJ
bjp-69267	162	15	also	also	ADV
bjp-69267	162	16	highlights	highlight	VERB
bjp-69267	162	17	its	its	PRON
bjp-69267	162	18	functional	functional	ADJ
bjp-69267	162	19	relevance	relevance	NOUN
bjp-69267	162	20	within	within	ADP
bjp-69267	162	21	biological	biological	ADJ
bjp-69267	162	22	systems	system	NOUN
bjp-69267	162	23	,	,	PUNCT
bjp-69267	162	24	making	make	VERB
bjp-69267	162	25	this	this	DET
bjp-69267	162	26	information	information	NOUN
bjp-69267	162	27	invaluable	invaluable	ADJ
bjp-69267	162	28	for	for	ADP
bjp-69267	162	29	structural	structural	ADJ
bjp-69267	162	30	biology	biology	NOUN
bjp-69267	162	31	and	and	CCONJ
bjp-69267	162	32	drug	drug	NOUN
bjp-69267	162	33	discovery	discovery	NOUN
bjp-69267	162	34	.	.	PUNCT
bjp-69267	163	1	nma	nma	PROPN
bjp-69267	163	2	analysis	analysis	NOUN
bjp-69267	163	3	of	of	ADP
bjp-69267	163	4	docked	docked	ADJ
bjp-69267	163	5	complexes	complex	NOUN
bjp-69267	163	6	was	be	AUX
bjp-69267	163	7	presented	present	VERB
bjp-69267	163	8	in	in	ADP
bjp-69267	163	9	supplementary	supplementary	ADJ
bjp-69267	163	10	figure	figure	NOUN
bjp-69267	163	11	1	1	NUM
bjp-69267	163	12	.	.	PUNCT
bjp-69267	163	13	affine	affine	NOUN
bjp-69267	163	14	arrows	arrow	NOUN
bjp-69267	163	15	of	of	ADP
bjp-69267	163	16	two	two	NUM
bjp-69267	163	17	colors	color	NOUN
bjp-69267	163	18	indicate	indicate	VERB
bjp-69267	163	19	mobility	mobility	NOUN
bjp-69267	163	20	or	or	CCONJ
bjp-69267	163	21	movement	movement	NOUN
bjp-69267	163	22	direction	direction	NOUN
bjp-69267	163	23	,	,	PUNCT
bjp-69267	163	24	with	with	ADP
bjp-69267	163	25	longer	long	ADJ
bjp-69267	163	26	arrows	arrow	NOUN
bjp-69267	163	27	indicating	indicate	VERB
bjp-69267	163	28	greater	great	ADJ
bjp-69267	163	29	movement	movement	NOUN
bjp-69267	163	30	.	.	PUNCT
bjp-69267	164	1	deformability	deformability	NOUN
bjp-69267	164	2	and	and	CCONJ
bjp-69267	164	3	factor	factor	NOUN
bjp-69267	164	4	b	b	PROPN
bjp-69267	164	5	provide	provide	VERB
bjp-69267	164	6	mobility	mobility	NOUN
bjp-69267	164	7	profiles	profile	NOUN
bjp-69267	164	8	of	of	ADP
bjp-69267	164	9	anchored	anchored	ADJ
bjp-69267	164	10	proteins	protein	NOUN
bjp-69267	164	11	.	.	PUNCT
bjp-69267	165	1	the	the	DET
bjp-69267	165	2	deformability	deformability	NOUN
bjp-69267	165	3	and	and	CCONJ
bjp-69267	165	4	b	b	NOUN
bjp-69267	165	5	-	-	PUNCT
bjp-69267	165	6	factors	factor	NOUN
bjp-69267	165	7	of	of	ADP
bjp-69267	165	8	the	the	DET
bjp-69267	165	9	complexes	complex	NOUN
bjp-69267	165	10	illustrate	illustrate	VERB
bjp-69267	165	11	peaks	peak	NOUN
bjp-69267	165	12	corresponding	correspond	VERB
bjp-69267	165	13	to	to	ADP
bjp-69267	165	14	protein	protein	NOUN
bjp-69267	165	15	deformability	deformability	NOUN
bjp-69267	165	16	regions	region	NOUN
bjp-69267	165	17	,	,	PUNCT
bjp-69267	165	18	with	with	ADP
bjp-69267	165	19	higher	high	ADJ
bjp-69267	165	20	peaks	peak	NOUN
bjp-69267	165	21	representing	represent	VERB
bjp-69267	165	22	regions	region	NOUN
bjp-69267	165	23	of	of	ADP
bjp-69267	165	24	high	high	ADJ
bjp-69267	165	25	deformability	deformability	NOUN
bjp-69267	165	26	(	(	PUNCT
bjp-69267	165	27	sumera	sumera	NOUN
bjp-69267	165	28	et	et	PROPN
bjp-69267	165	29	al	al	PROPN
bjp-69267	165	30	.	.	PROPN
bjp-69267	165	31	,	,	PUNCT
bjp-69267	165	32	2022	2022	NUM
bjp-69267	165	33	)	)	PUNCT
bjp-69267	165	34	.	.	PUNCT
bjp-69267	166	1	the	the	DET
bjp-69267	166	2	highest	high	ADJ
bjp-69267	166	3	peaks	peak	NOUN
bjp-69267	166	4	are	be	AUX
bjp-69267	166	5	recorded	record	VERB
bjp-69267	166	6	for	for	ADP
bjp-69267	166	7	complex	complex	ADJ
bjp-69267	166	8	1kzn	1kzn	NUM
bjp-69267	166	9	-	-	PUNCT
bjp-69267	166	10	pyrazoline	pyrazoline	NOUN
bjp-69267	166	11	carboxamide	carboxamide	NOUN
bjp-69267	166	12	,	,	PUNCT
bjp-69267	166	13	followed	follow	VERB
bjp-69267	166	14	by	by	ADP
bjp-69267	166	15	3hun	3hun	PROPN
bjp-69267	166	16	-	-	PUNCT
bjp-69267	166	17	pyrazoline	pyrazoline	NOUN
bjp-69267	166	18	carboxamide	carboxamide	NOUN
bjp-69267	166	19	and	and	CCONJ
bjp-69267	166	20	7kcy	7kcy	NOUN
bjp-69267	166	21	-	-	PUNCT
bjp-69267	166	22	pyrazoline	pyrazoline	NOUN
bjp-69267	166	23	carboxamide	carboxamide	NOUN
bjp-69267	166	24	,	,	PUNCT
bjp-69267	166	25	which	which	PRON
bjp-69267	166	26	exhibit	exhibit	VERB
bjp-69267	166	27	high	high	ADJ
bjp-69267	166	28	deformability	deformability	NOUN
bjp-69267	166	29	,	,	PUNCT
bjp-69267	166	30	while	while	SCONJ
bjp-69267	166	31	complex	complex	ADJ
bjp-69267	166	32	5tz1pyrazoline	5tz1pyrazoline	NUM
bjp-69267	166	33	carboxamide	carboxamide	NOUN
bjp-69267	166	34	shows	show	VERB
bjp-69267	166	35	lesser	less	ADJ
bjp-69267	166	36	deformability	deformability	NOUN
bjp-69267	166	37	.	.	PUNCT
bjp-69267	167	1	bfactor	bfactor	PROPN
bjp-69267	167	2	diagrams	diagram	NOUN
bjp-69267	167	3	provide	provide	VERB
bjp-69267	167	4	a	a	DET
bjp-69267	167	5	comparison	comparison	NOUN
bjp-69267	167	6	between	between	ADP
bjp-69267	167	7	the	the	DET
bjp-69267	167	8	nma	nma	PROPN
bjp-69267	167	9	and	and	CCONJ
bjp-69267	167	10	pdb	pdb	PROPN
bjp-69267	167	11	fields	field	NOUN
bjp-69267	167	12	of	of	ADP
bjp-69267	167	13	the	the	DET
bjp-69267	167	14	complexes	complex	NOUN
bjp-69267	167	15	.	.	PUNCT
bjp-69267	168	1	complex	complex	ADJ
bjp-69267	168	2	5tz1pyr	5tz1pyr	PROPN
bjp-69267	168	3	had	have	VERB
bjp-69267	168	4	a	a	DET
bjp-69267	168	5	consistent	consistent	ADJ
bjp-69267	168	6	b	b	NOUN
bjp-69267	168	7	-	-	PUNCT
bjp-69267	168	8	factor	factor	NOUN
bjp-69267	168	9	score	score	NOUN
bjp-69267	168	10	,	,	PUNCT
bjp-69267	168	11	but	but	CCONJ
bjp-69267	168	12	1kznpyrazoline	1kznpyrazoline	NUM
bjp-69267	168	13	carboxamide	carboxamide	NOUN
bjp-69267	168	14	,	,	PUNCT
bjp-69267	168	15	3hun	3hun	PROPN
bjp-69267	168	16	-	-	PUNCT
bjp-69267	168	17	pyrazoline	pyrazoline	NOUN
bjp-69267	168	18	carboxamide	carboxamide	NOUN
bjp-69267	168	19	,	,	PUNCT
bjp-69267	168	20	and	and	CCONJ
bjp-69267	168	21	7kcy	7kcy	NOUN
bjp-69267	168	22	-	-	ADJ
bjp-69267	168	23	pyrazoline	pyrazoline	NOUN
bjp-69267	168	24	carboxamide	carboxamide	NOUN
bjp-69267	168	25	fluctuated	fluctuate	VERB
bjp-69267	168	26	more	more	ADV
bjp-69267	168	27	,	,	PUNCT
bjp-69267	168	28	each	each	PRON
bjp-69267	168	29	having	have	VERB
bjp-69267	168	30	significant	significant	ADJ
bjp-69267	168	31	peaks	peak	NOUN
bjp-69267	168	32	.	.	PUNCT
bjp-69267	169	1	eigenvalues	eigenvalue	NOUN
bjp-69267	169	2	and	and	CCONJ
bjp-69267	169	3	variance	variance	NOUN
bjp-69267	169	4	are	be	AUX
bjp-69267	169	5	inversely	inversely	ADV
bjp-69267	169	6	related	relate	VERB
bjp-69267	169	7	to	to	ADP
bjp-69267	169	8	each	each	DET
bjp-69267	169	9	normal	normal	ADJ
bjp-69267	169	10	mode	mode	NOUN
bjp-69267	169	11	(	(	PUNCT
bjp-69267	169	12	lópez	lópez	NOUN
bjp-69267	169	13	-	-	PUNCT
bjp-69267	169	14	blanco	blanco	PROPN
bjp-69267	169	15	et	et	PROPN
bjp-69267	169	16	al	al	PROPN
bjp-69267	169	17	.	.	PROPN
bjp-69267	169	18	,	,	PUNCT
bjp-69267	169	19	2014	2014	NUM
bjp-69267	169	20	)	)	PUNCT
bjp-69267	169	21	.	.	PUNCT
bjp-69267	170	1	the	the	DET
bjp-69267	170	2	target	target	NOUN
bjp-69267	170	3	protein	protein	NOUN
bjp-69267	170	4	's	's	PART
bjp-69267	170	5	variance	variance	NOUN
bjp-69267	170	6	graph	graph	NOUN
bjp-69267	170	7	displays	display	VERB
bjp-69267	170	8	individual	individual	ADJ
bjp-69267	170	9	variance	variance	NOUN
bjp-69267	170	10	with	with	ADP
bjp-69267	170	11	purple	purple	ADJ
bjp-69267	170	12	bars	bar	NOUN
bjp-69267	170	13	,	,	PUNCT
bjp-69267	170	14	while	while	SCONJ
bjp-69267	170	15	green	green	ADJ
bjp-69267	170	16	bars	bar	NOUN
bjp-69267	170	17	represent	represent	VERB
bjp-69267	170	18	cumulative	cumulative	ADJ
bjp-69267	170	19	variance	variance	NOUN
bjp-69267	170	20	.	.	PUNCT
bjp-69267	171	1	eigenvalues	eigenvalue	NOUN
bjp-69267	171	2	describe	describe	VERB
bjp-69267	171	3	the	the	DET
bjp-69267	171	4	rigidity	rigidity	NOUN
bjp-69267	171	5	of	of	ADP
bjp-69267	171	6	movement	movement	NOUN
bjp-69267	171	7	,	,	PUNCT
bjp-69267	171	8	directly	directly	ADV
bjp-69267	171	9	related	relate	VERB
bjp-69267	171	10	to	to	ADP
bjp-69267	171	11	the	the	DET
bjp-69267	171	12	energy	energy	NOUN
bjp-69267	171	13	needed	need	VERB
bjp-69267	171	14	to	to	PART
bjp-69267	171	15	flex	flex	VERB
bjp-69267	171	16	the	the	DET
bjp-69267	171	17	protein	protein	NOUN
bjp-69267	171	18	(	(	PUNCT
bjp-69267	171	19	quezada	quezada	PROPN
bjp-69267	171	20	et	et	PROPN
bjp-69267	171	21	al	al	PROPN
bjp-69267	171	22	.	.	PROPN
bjp-69267	171	23	,	,	PUNCT
bjp-69267	171	24	2017	2017	NUM
bjp-69267	171	25	)	)	PUNCT
bjp-69267	171	26	.	.	PUNCT
bjp-69267	172	1	the	the	DET
bjp-69267	172	2	protein	protein	NOUN
bjp-69267	172	3	structure	structure	NOUN
bjp-69267	172	4	deforms	deform	VERB
bjp-69267	172	5	most	most	ADV
bjp-69267	172	6	efficiently	efficiently	ADV
bjp-69267	172	7	at	at	ADP
bjp-69267	172	8	a	a	DET
bjp-69267	172	9	shorter	short	ADJ
bjp-69267	172	10	energy	energy	NOUN
bjp-69267	172	11	range	range	NOUN
bjp-69267	172	12	(	(	PUNCT
bjp-69267	172	13	may	may	AUX
bjp-69267	172	14	and	and	CCONJ
bjp-69267	172	15	zacharias	zacharias	PROPN
bjp-69267	172	16	,	,	PUNCT
bjp-69267	172	17	2008	2008	NUM
bjp-69267	172	18	)	)	PUNCT
bjp-69267	172	19	.	.	PUNCT
bjp-69267	173	1	eigenvalue	eigenvalue	PROPN
bjp-69267	173	2	and	and	CCONJ
bjp-69267	173	3	variance	variance	NOUN
bjp-69267	173	4	map	map	NOUN
bjp-69267	173	5	are	be	AUX
bjp-69267	173	6	inversely	inversely	ADV
bjp-69267	173	7	related	relate	VERB
bjp-69267	173	8	(	(	PUNCT
bjp-69267	173	9	szczepankiewicz	szczepankiewicz	NOUN
bjp-69267	173	10	et	et	PROPN
bjp-69267	173	11	al	al	PROPN
bjp-69267	173	12	.	.	PROPN
bjp-69267	173	13	,	,	PUNCT
bjp-69267	173	14	2016	2016	NUM
bjp-69267	173	15	)	)	PUNCT
bjp-69267	173	16	.	.	PUNCT
bjp-69267	174	1	complex	complex	ADJ
bjp-69267	174	2	5tz1	5tz1	ADV
bjp-69267	174	3	-	-	PUNCT
bjp-69267	174	4	pyr	pyr	NOUN
bjp-69267	174	5	had	have	VERB
bjp-69267	174	6	the	the	DET
bjp-69267	174	7	lowest	low	ADJ
bjp-69267	174	8	eigenvalue	eigenvalue	NOUN
bjp-69267	174	9	of	of	ADP
bjp-69267	174	10	1.973543e05	1.973543e05	NUM
bjp-69267	174	11	,	,	PUNCT
bjp-69267	174	12	followed	follow	VERB
bjp-69267	174	13	in	in	ADP
bjp-69267	174	14	ascending	ascend	VERB
bjp-69267	174	15	order	order	NOUN
bjp-69267	174	16	by	by	ADP
bjp-69267	174	17	values	value	NOUN
bjp-69267	174	18	of	of	ADP
bjp-69267	174	19	2.185665e05	2.185665e05	NUM
bjp-69267	174	20	,	,	PUNCT
bjp-69267	174	21	8.826441e-05	8.826441e-05	NUM
bjp-69267	174	22	,	,	PUNCT
bjp-69267	174	23	and	and	CCONJ
bjp-69267	174	24	5.30424e-04	5.30424e-04	NUM
bjp-69267	174	25	for	for	ADP
bjp-69267	174	26	1kzn	1kzn	PROPN
bjp-69267	174	27	-	-	PUNCT
bjp-69267	174	28	pyrazoline	pyrazoline	NOUN
bjp-69267	174	29	carboxamide	carboxamide	NOUN
bjp-69267	174	30	,	,	PUNCT
bjp-69267	174	31	3hun	3hun	PROPN
bjp-69267	174	32	-	-	PUNCT
bjp-69267	174	33	pyrazoline	pyrazoline	NOUN
bjp-69267	174	34	carboxamide	carboxamide	NOUN
bjp-69267	174	35	,	,	PUNCT
bjp-69267	174	36	and	and	CCONJ
bjp-69267	174	37	7kcy	7kcy	NOUN
bjp-69267	174	38	-	-	ADJ
bjp-69267	174	39	pyrazoline	pyrazoline	NOUN
bjp-69267	174	40	carboxamide	carboxamide	NOUN
bjp-69267	174	41	respectively	respectively	ADV
bjp-69267	174	42	.	.	PUNCT
bjp-69267	175	1	the	the	DET
bjp-69267	175	2	covariance	covariance	NOUN
bjp-69267	175	3	matrix	matrix	NOUN
bjp-69267	175	4	of	of	ADP
bjp-69267	175	5	the	the	DET
bjp-69267	175	6	complex	complex	NOUN
bjp-69267	175	7	shows	show	VERB
bjp-69267	175	8	correlations	correlation	NOUN
bjp-69267	175	9	between	between	ADP
bjp-69267	175	10	complex	complex	ADJ
bjp-69267	175	11	residues	residue	NOUN
bjp-69267	175	12	.	.	PUNCT
bjp-69267	176	1	the	the	DET
bjp-69267	176	2	red	red	ADJ
bjp-69267	176	3	color	color	NOUN
bjp-69267	176	4	of	of	ADP
bjp-69267	176	5	the	the	DET
bjp-69267	176	6	matrix	matrix	NOUN
bjp-69267	176	7	illustrates	illustrate	VERB
bjp-69267	176	8	the	the	DET
bjp-69267	176	9	good	good	ADJ
bjp-69267	176	10	correlation	correlation	NOUN
bjp-69267	176	11	between	between	ADP
bjp-69267	176	12	residues	residue	NOUN
bjp-69267	176	13	,	,	PUNCT
bjp-69267	176	14	while	while	SCONJ
bjp-69267	176	15	white	white	ADJ
bjp-69267	176	16	indicates	indicate	VERB
bjp-69267	176	17	uncorrelated	uncorrelated	ADJ
bjp-69267	176	18	movement	movement	NOUN
bjp-69267	176	19	.	.	PUNCT
bjp-69267	177	1	additionally	additionally	ADV
bjp-69267	177	2	,	,	PUNCT
bjp-69267	177	3	the	the	DET
bjp-69267	177	4	blue	blue	ADJ
bjp-69267	177	5	color	color	NOUN
bjp-69267	177	6	indicates	indicate	VERB
bjp-69267	177	7	anti	anti	ADJ
bjp-69267	177	8	-	-	NOUN
bjp-69267	177	9	correlations	correlation	NOUN
bjp-69267	177	10	.	.	PUNCT
bjp-69267	178	1	greater	great	ADJ
bjp-69267	178	2	correlation	correlation	NOUN
bjp-69267	178	3	signifies	signify	VERB
bjp-69267	178	4	higher	high	ADJ
bjp-69267	178	5	complexity	complexity	NOUN
bjp-69267	178	6	(	(	PUNCT
bjp-69267	178	7	kumar	kumar	PROPN
bjp-69267	178	8	et	et	PROPN
bjp-69267	178	9	al	al	PROPN
bjp-69267	178	10	.	.	PROPN
bjp-69267	178	11	,	,	PUNCT
bjp-69267	178	12	2014	2014	NUM
bjp-69267	178	13	)	)	PUNCT
bjp-69267	178	14	.	.	PUNCT
bjp-69267	179	1	elastic	elastic	ADJ
bjp-69267	179	2	network	network	NOUN
bjp-69267	179	3	protein	protein	NOUN
bjp-69267	179	4	maps	map	NOUN
bjp-69267	179	5	show	show	VERB
bjp-69267	179	6	associations	association	NOUN
bjp-69267	179	7	between	between	ADP
bjp-69267	179	8	atoms	atom	NOUN
bjp-69267	179	9	,	,	PUNCT
bjp-69267	179	10	with	with	ADP
bjp-69267	179	11	darker	dark	ADJ
bjp-69267	179	12	gray	gray	ADJ
bjp-69267	179	13	areas	area	NOUN
bjp-69267	179	14	indicating	indicate	VERB
bjp-69267	179	15	more	more	ADV
bjp-69267	179	16	rigid	rigid	ADJ
bjp-69267	179	17	parts	part	NOUN
bjp-69267	179	18	(	(	PUNCT
bjp-69267	179	19	abdelli	abdelli	ADV
bjp-69267	179	20	et	et	PROPN
bjp-69267	179	21	al	al	PROPN
bjp-69267	179	22	.	.	PROPN
bjp-69267	179	23	,	,	PUNCT
bjp-69267	179	24	2021	2021	NUM
bjp-69267	179	25	)	)	PUNCT
bjp-69267	179	26	.	.	PUNCT
bjp-69267	180	1	conclusion	conclusion	NOUN
bjp-69267	180	2	the	the	DET
bjp-69267	180	3	synthesized	synthesize	VERB
bjp-69267	180	4	pyrazoline	pyrazoline	NOUN
bjp-69267	180	5	carboxamide	carboxamide	NOUN
bjp-69267	180	6	compound	compound	NOUN
bjp-69267	180	7	showed	show	VERB
bjp-69267	180	8	potent	potent	ADJ
bjp-69267	180	9	antimicrobial	antimicrobial	ADJ
bjp-69267	180	10	activity	activity	NOUN
bjp-69267	180	11	,	,	PUNCT
bjp-69267	180	12	notably	notably	ADV
bjp-69267	180	13	against	against	ADP
bjp-69267	180	14	l.	l.	PROPN
bjp-69267	180	15	monocytogenes	monocytogenes	PROPN
bjp-69267	180	16	and	and	CCONJ
bjp-69267	180	17	c.	c.	NOUN
bjp-69267	180	18	albicans	albican	NOUN
bjp-69267	180	19	.	.	PUNCT
bjp-69267	181	1	its	its	PRON
bjp-69267	181	2	confirmed	confirmed	ADJ
bjp-69267	181	3	structural	structural	ADJ
bjp-69267	181	4	integrity	integrity	NOUN
bjp-69267	181	5	,	,	PUNCT
bjp-69267	181	6	favorable	favorable	ADJ
bjp-69267	181	7	drug	drug	NOUN
bjp-69267	181	8	characteristics	characteristic	NOUN
bjp-69267	181	9	,	,	PUNCT
bjp-69267	181	10	and	and	CCONJ
bjp-69267	181	11	promising	promise	VERB
bjp-69267	181	12	molecular	molecular	ADJ
bjp-69267	181	13	interactions	interaction	NOUN
bjp-69267	181	14	indicate	indicate	VERB
bjp-69267	181	15	that	that	SCONJ
bjp-69267	181	16	it	it	PRON
bjp-69267	181	17	could	could	AUX
bjp-69267	181	18	be	be	AUX
bjp-69267	181	19	a	a	DET
bjp-69267	181	20	compelling	compelling	ADJ
bjp-69267	181	21	candidate	candidate	NOUN
bjp-69267	181	22	for	for	ADP
bjp-69267	181	23	drug	drug	NOUN
bjp-69267	181	24	development	development	NOUN
bjp-69267	181	25	.	.	PUNCT
bjp-69267	182	1	financial	financial	ADJ
bjp-69267	182	2	support	support	NOUN
bjp-69267	182	3	self	self	NOUN
bjp-69267	182	4	-	-	PUNCT
bjp-69267	182	5	funded	fund	VERB
bjp-69267	182	6	ethical	ethical	ADJ
bjp-69267	182	7	issue	issue	NOUN
bjp-69267	182	8	the	the	DET
bjp-69267	182	9	study	study	NOUN
bjp-69267	182	10	protocol	protocol	NOUN
bjp-69267	182	11	was	be	AUX
bjp-69267	182	12	approved	approve	VERB
bjp-69267	182	13	the	the	DET
bjp-69267	182	14	institutional	institutional	ADJ
bjp-69267	182	15	ethical	ethical	ADJ
bjp-69267	182	16	committee	committee	NOUN
bjp-69267	182	17	conflict	conflict	NOUN
bjp-69267	182	18	of	of	ADP
bjp-69267	182	19	interest	interest	NOUN
bjp-69267	182	20	authors	author	NOUN
bjp-69267	182	21	declare	declare	VERB
bjp-69267	182	22	no	no	DET
bjp-69267	182	23	conflict	conflict	NOUN
bjp-69267	182	24	of	of	ADP
bjp-69267	182	25	interest	interest	NOUN
bjp-69267	182	26	references	reference	NOUN
bjp-69267	182	27	abdelli	abdelli	ADV
bjp-69267	182	28	i	i	PRON
bjp-69267	182	29	,	,	PUNCT
bjp-69267	182	30	hassani	hassani	PROPN
bjp-69267	182	31	f	f	PROPN
bjp-69267	182	32	,	,	PUNCT
bjp-69267	182	33	bekkel	bekkel	NOUN
bjp-69267	182	34	brikci	brikci	PROPN
bjp-69267	182	35	s	s	PROPN
bjp-69267	182	36	,	,	PUNCT
bjp-69267	182	37	ghalem	ghalem	PROPN
bjp-69267	182	38	s.	s.	PROPN
bjp-69267	182	39	in	in	ADP
bjp-69267	182	40	silico	silico	NOUN
bjp-69267	182	41	study	study	VERB
bjp-69267	182	42	the	the	DET
bjp-69267	182	43	inhibition	inhibition	NOUN
bjp-69267	182	44	of	of	ADP
bjp-69267	182	45	angiotensin	angiotensin	NOUN
bjp-69267	182	46	converting	convert	VERB
bjp-69267	182	47	enzyme	enzyme	NOUN
bjp-69267	182	48	2	2	NUM
bjp-69267	182	49	receptor	receptor	NOUN
bjp-69267	182	50	of	of	ADP
bjp-69267	182	51	covid-19	covid-19	PROPN
bjp-69267	182	52	by	by	ADP
bjp-69267	182	53	ammoides	ammoide	NOUN
bjp-69267	182	54	verticillata	verticillata	VERB
bjp-69267	182	55	components	component	NOUN
bjp-69267	182	56	harvested	harvest	VERB
bjp-69267	182	57	from	from	ADP
bjp-69267	182	58	western	western	ADJ
bjp-69267	182	59	algeria	algeria	PROPN
bjp-69267	182	60	.	.	PUNCT
bjp-69267	183	1	j	j	PROPN
bjp-69267	183	2	biomol	biomol	PROPN
bjp-69267	183	3	struct	struct	NOUN
bjp-69267	183	4	dyn	dyn	NOUN
bjp-69267	183	5	.	.	PUNCT
bjp-69267	183	6	2021	2021	NUM
bjp-69267	183	7	;	;	PUNCT
bjp-69267	183	8	39	39	NUM
bjp-69267	183	9	:	:	PUNCT
bjp-69267	183	10	3263	3263	NUM
bjp-69267	183	11	-	-	SYM
bjp-69267	183	12	76	76	NUM
bjp-69267	183	13	.	.	PUNCT
bjp-69267	184	1	ahmad	ahmad	PROPN
bjp-69267	184	2	i	i	PRON
bjp-69267	184	3	,	,	PUNCT
bjp-69267	184	4	khan	khan	PROPN
bjp-69267	184	5	h	h	PROPN
bjp-69267	184	6	,	,	PUNCT
bjp-69267	184	7	serdaroğlu	serdaroğlu	PROPN
bjp-69267	184	8	g.	g.	PROPN
bjp-69267	184	9	physicochemical	physicochemical	ADJ
bjp-69267	184	10	properties	property	NOUN
bjp-69267	184	11	,	,	PUNCT
bjp-69267	184	12	drug	drug	NOUN
bjp-69267	184	13	likeness	likeness	NOUN
bjp-69267	184	14	,	,	PUNCT
bjp-69267	184	15	admet	admet	PROPN
bjp-69267	184	16	,	,	PUNCT
bjp-69267	184	17	dft	dft	PROPN
bjp-69267	184	18	studies	study	NOUN
bjp-69267	184	19	,	,	PUNCT
bjp-69267	184	20	and	and	CCONJ
bjp-69267	184	21	in	in	ADP
bjp-69267	184	22	vitro	vitro	X
bjp-69267	184	23	antioxidant	antioxidant	ADJ
bjp-69267	184	24	activity	activity	NOUN
bjp-69267	184	25	of	of	ADP
bjp-69267	184	26	oxindole	oxindole	NOUN
bjp-69267	184	27	derivatives	derivative	NOUN
bjp-69267	184	28	.	.	PUNCT
bjp-69267	185	1	comput	comput	VERB
bjp-69267	185	2	biol	biol	PROPN
bjp-69267	185	3	chem	chem	NOUN
bjp-69267	185	4	.	.	PUNCT
bjp-69267	186	1	2023	2023	NUM
bjp-69267	186	2	;	;	PUNCT
bjp-69267	186	3	104	104	NUM
bjp-69267	186	4	:	:	SYM
bjp-69267	186	5	107861	107861	NUM
bjp-69267	186	6	-	-	SYM
bjp-69267	186	7	80	80	NUM
bjp-69267	186	8	.	.	PUNCT
bjp-69267	187	1	aslam	aslam	PROPN
bjp-69267	187	2	b	b	PROPN
bjp-69267	187	3	,	,	PUNCT
bjp-69267	187	4	wang	wang	PROPN
bjp-69267	187	5	w	w	PROPN
bjp-69267	187	6	,	,	PUNCT
bjp-69267	187	7	arshad	arshad	PROPN
bjp-69267	187	8	mi	mi	PROPN
bjp-69267	187	9	,	,	PUNCT
bjp-69267	187	10	khurshid	khurshid	PROPN
bjp-69267	187	11	m	m	PROPN
bjp-69267	187	12	,	,	PUNCT
bjp-69267	187	13	muzammil	muzammil	PROPN
bjp-69267	187	14	s	s	PROPN
bjp-69267	187	15	,	,	PUNCT
bjp-69267	187	16	rasool	rasool	PROPN
bjp-69267	187	17	mh	mh	PROPN
bjp-69267	187	18	,	,	PUNCT
bjp-69267	187	19	nisar	nisar	PROPN
bjp-69267	187	20	ma	ma	PROPN
bjp-69267	187	21	,	,	PUNCT
bjp-69267	187	22	alvi	alvi	PROPN
bjp-69267	187	23	rf	rf	PROPN
bjp-69267	187	24	,	,	PUNCT
bjp-69267	187	25	aslam	aslam	PROPN
bjp-69267	187	26	ma	ma	PROPN
bjp-69267	187	27	,	,	PUNCT
bjp-69267	187	28	qamar	qamar	PROPN
bjp-69267	187	29	mu	mu	PROPN
bjp-69267	187	30	.	.	PUNCT
bjp-69267	188	1	antibiotic	antibiotic	ADJ
bjp-69267	188	2	resistance	resistance	NOUN
bjp-69267	188	3	:	:	PUNCT
bjp-69267	188	4	a	a	DET
bjp-69267	188	5	rundown	rundown	NOUN
bjp-69267	188	6	of	of	ADP
bjp-69267	188	7	a	a	DET
bjp-69267	188	8	global	global	ADJ
bjp-69267	188	9	crisis	crisis	NOUN
bjp-69267	188	10	.	.	PUNCT
bjp-69267	189	1	infect	infect	VERB
bjp-69267	189	2	drug	drug	NOUN
bjp-69267	189	3	resist	resist	NOUN
bjp-69267	189	4	.	.	PUNCT
bjp-69267	190	1	2018	2018	NUM
bjp-69267	190	2	;	;	PUNCT
bjp-69267	190	3	11	11	NUM
bjp-69267	190	4	:	:	SYM
bjp-69267	190	5	1645	1645	NUM
bjp-69267	190	6	-	-	SYM
bjp-69267	190	7	58	58	NUM
bjp-69267	190	8	.	.	PUNCT
bjp-69267	191	1	baell	baell	VERB
bjp-69267	191	2	jb	jb	PROPN
bjp-69267	191	3	,	,	PUNCT
bjp-69267	191	4	holloway	holloway	PROPN
bjp-69267	191	5	ga	ga	PROPN
bjp-69267	191	6	.	.	PUNCT
bjp-69267	192	1	new	new	ADJ
bjp-69267	192	2	substructure	substructure	NOUN
bjp-69267	192	3	filters	filter	NOUN
bjp-69267	192	4	for	for	ADP
bjp-69267	192	5	removal	removal	NOUN
bjp-69267	192	6	of	of	ADP
bjp-69267	192	7	pan	pan	PROPN
bjp-69267	192	8	assay	assay	PROPN
bjp-69267	192	9	interference	interference	NOUN
bjp-69267	192	10	compounds	compound	NOUN
bjp-69267	192	11	(	(	PUNCT
bjp-69267	192	12	pains	pain	NOUN
bjp-69267	192	13	)	)	PUNCT
bjp-69267	192	14	from	from	ADP
bjp-69267	192	15	screening	screen	VERB
bjp-69267	192	16	libraries	library	NOUN
bjp-69267	192	17	and	and	CCONJ
bjp-69267	192	18	for	for	ADP
bjp-69267	192	19	their	their	PRON
bjp-69267	192	20	exclusion	exclusion	NOUN
bjp-69267	192	21	in	in	ADP
bjp-69267	192	22	bioassays	bioassay	NOUN
bjp-69267	192	23	.	.	PUNCT
bjp-69267	193	1	j	j	PROPN
bjp-69267	193	2	med	med	PROPN
bjp-69267	193	3	chem	chem	NOUN
bjp-69267	193	4	.	.	PUNCT
bjp-69267	194	1	2010	2010	NUM
bjp-69267	194	2	;	;	PUNCT
bjp-69267	194	3	53	53	NUM
bjp-69267	194	4	:	:	SYM
bjp-69267	194	5	2719	2719	NUM
bjp-69267	194	6	-	-	SYM
bjp-69267	194	7	40	40	NUM
bjp-69267	194	8	.	.	PUNCT
bjp-69267	195	1	burke	burke	PROPN
bjp-69267	195	2	a	a	DET
bjp-69267	195	3	,	,	PUNCT
bjp-69267	195	4	di	di	X
bjp-69267	195	5	filippo	filippo	PROPN
bjp-69267	195	6	m	m	PROPN
bjp-69267	195	7	,	,	PUNCT
bjp-69267	195	8	spiccio	spiccio	PROPN
bjp-69267	195	9	s	s	PART
bjp-69267	195	10	,	,	PUNCT
bjp-69267	195	11	schito	schito	ADJ
bjp-69267	195	12	am	am	PROPN
bjp-69267	195	13	,	,	PUNCT
bjp-69267	195	14	caviglia	caviglia	PROPN
bjp-69267	195	15	d	d	NOUN
bjp-69267	195	16	,	,	PUNCT
bjp-69267	195	17	brullo	brullo	NOUN
bjp-69267	195	18	c	c	PROPN
bjp-69267	195	19	,	,	PUNCT
bjp-69267	195	20	baumann	baumann	PROPN
bjp-69267	195	21	m.	m.	PROPN
bjp-69267	195	22	antimicrobial	antimicrobial	ADJ
bjp-69267	195	23	evaluation	evaluation	NOUN
bjp-69267	195	24	of	of	ADP
bjp-69267	195	25	new	new	ADJ
bjp-69267	195	26	pyrazoles	pyrazole	NOUN
bjp-69267	195	27	,	,	PUNCT
bjp-69267	195	28	indazoles	indazole	NOUN
bjp-69267	195	29	and	and	CCONJ
bjp-69267	195	30	pyrazolines	pyrazoline	NOUN
bjp-69267	195	31	prepared	prepare	VERB
bjp-69267	195	32	in	in	ADP
bjp-69267	195	33	continuous	continuous	ADJ
bjp-69267	195	34	flow	flow	NOUN
bjp-69267	195	35	mode	mode	NOUN
bjp-69267	195	36	.	.	PUNCT
bjp-69267	196	1	int	int	PROPN
bjp-69267	196	2	j	j	PROPN
bjp-69267	196	3	mol	mol	ADP
bjp-69267	196	4	sci	sci	PROPN
bjp-69267	196	5	.	.	PROPN
bjp-69267	196	6	2023	2023	NUM
bjp-69267	196	7	;	;	PUNCT
bjp-69267	196	8	24	24	NUM
bjp-69267	196	9	:	:	PUNCT
bjp-69267	196	10	5319	5319	NUM
bjp-69267	196	11	-	-	SYM
bjp-69267	196	12	31	31	NUM
bjp-69267	196	13	.	.	PUNCT
bjp-69267	197	1	chen	chen	PROPN
bjp-69267	197	2	h	h	PROPN
bjp-69267	197	3	,	,	PUNCT
bjp-69267	197	4	bajorath	bajorath	PROPN
bjp-69267	197	5	j.	j.	PROPN
bjp-69267	197	6	designing	design	VERB
bjp-69267	197	7	highly	highly	ADV
bjp-69267	197	8	potent	potent	ADJ
bjp-69267	197	9	compounds	compound	NOUN
bjp-69267	197	10	using	use	VERB
bjp-69267	197	11	a	a	DET
bjp-69267	197	12	chemical	chemical	ADJ
bjp-69267	197	13	language	language	NOUN
bjp-69267	197	14	model	model	NOUN
bjp-69267	197	15	.	.	PUNCT
bjp-69267	198	1	sci	sci	PROPN
bjp-69267	198	2	rep	rep	PROPN
bjp-69267	198	3	.	.	PROPN
bjp-69267	198	4	2023	2023	NUM
bjp-69267	198	5	;	;	PUNCT
bjp-69267	198	6	13	13	NUM
bjp-69267	198	7	:	:	SYM
bjp-69267	198	8	7412	7412	NUM
bjp-69267	198	9	-	-	SYM
bjp-69267	198	10	23	23	NUM
bjp-69267	198	11	.	.	PUNCT
bjp-69267	199	1	daina	daina	PROPN
bjp-69267	199	2	a	a	PROPN
bjp-69267	199	3	,	,	PUNCT
bjp-69267	199	4	michielin	michielin	PROPN
bjp-69267	199	5	o	o	NOUN
bjp-69267	199	6	,	,	PUNCT
bjp-69267	199	7	zoete	zoete	PROPN
bjp-69267	199	8	v.	v.	ADP
bjp-69267	199	9	swissadme	swissadme	PROPN
bjp-69267	199	10	:	:	PUNCT
bjp-69267	199	11	a	a	DET
bjp-69267	199	12	free	free	ADJ
bjp-69267	199	13	web	web	NOUN
bjp-69267	199	14	tool	tool	NOUN
bjp-69267	199	15	to	to	PART
bjp-69267	199	16	evaluate	evaluate	VERB
bjp-69267	199	17	pharmacokinetics	pharmacokinetic	NOUN
bjp-69267	199	18	,	,	PUNCT
bjp-69267	199	19	drug	drug	NOUN
bjp-69267	199	20	-	-	PUNCT
bjp-69267	199	21	likeness	likeness	NOUN
bjp-69267	199	22	and	and	CCONJ
bjp-69267	199	23	medicinal	medicinal	ADJ
bjp-69267	199	24	160	160	NUM
bjp-69267	199	25	bangladesh	bangladesh	PROPN
bjp-69267	199	26	j	j	PROPN
bjp-69267	199	27	pharmacol	pharmacol	PROPN
bjp-69267	199	28	2023	2023	NUM
bjp-69267	199	29	;	;	PUNCT
bjp-69267	199	30	18	18	NUM
bjp-69267	199	31	:	:	SYM
bjp-69267	199	32	152	152	NUM
bjp-69267	199	33	-	-	SYM
bjp-69267	199	34	161	161	NUM
bjp-69267	199	35	author	author	NOUN
bjp-69267	199	36	info	info	NOUN
bjp-69267	199	37	farouk	farouk	PROPN
bjp-69267	199	38	boudou	boudou	PROPN
bjp-69267	199	39	(	(	PUNCT
bjp-69267	199	40	principal	principal	ADJ
bjp-69267	199	41	contact	contact	NOUN
bjp-69267	199	42	)	)	PUNCT
bjp-69267	200	1	e	e	NOUN
bjp-69267	200	2	-	-	NOUN
bjp-69267	200	3	mail	mail	NOUN
bjp-69267	200	4	:	:	PUNCT
bjp-69267	200	5	drfarouk.boudou@gmail.com	drfarouk.boudou@gmail.com	X
bjp-69267	200	6	chemistry	chemistry	NOUN
bjp-69267	200	7	friendliness	friendliness	NOUN
bjp-69267	200	8	of	of	ADP
bjp-69267	200	9	small	small	ADJ
bjp-69267	200	10	molecules	molecule	NOUN
bjp-69267	200	11	.	.	PUNCT
bjp-69267	201	1	sci	sci	PROPN
bjp-69267	201	2	rep	rep	PROPN
bjp-69267	201	3	.	.	PROPN
bjp-69267	201	4	2017	2017	NUM
bjp-69267	201	5	;	;	PUNCT
bjp-69267	201	6	7	7	NUM
bjp-69267	201	7	:	:	SYM
bjp-69267	201	8	42717	42717	NUM
bjp-69267	201	9	.	.	PUNCT
bjp-69267	202	1	daisley	daisley	PROPN
bjp-69267	202	2	b	b	PROPN
bjp-69267	202	3	,	,	PUNCT
bjp-69267	202	4	koenig	koenig	PROPN
bjp-69267	202	5	ad	ad	NOUN
bjp-69267	202	6	,	,	PUNCT
bjp-69267	202	7	engelbrecht	engelbrecht	NOUN
bjp-69267	202	8	k	k	NOUN
bjp-69267	202	9	,	,	PUNCT
bjp-69267	202	10	doney	doney	PROPN
bjp-69267	202	11	l	l	PROPN
bjp-69267	202	12	,	,	PUNCT
bjp-69267	202	13	hards	hards	PROPN
bjp-69267	202	14	k	k	PROPN
bjp-69267	202	15	,	,	PUNCT
bjp-69267	202	16	al	al	PROPN
bjp-69267	202	17	kf	kf	PROPN
bjp-69267	202	18	,	,	PUNCT
bjp-69267	202	19	reid	reid	PROPN
bjp-69267	202	20	g	g	PROPN
bjp-69267	202	21	,	,	PUNCT
bjp-69267	202	22	burton	burton	PROPN
bjp-69267	202	23	jp	jp	PROPN
bjp-69267	202	24	.	.	PUNCT
bjp-69267	203	1	emerging	emerge	VERB
bjp-69267	203	2	connections	connection	NOUN
bjp-69267	203	3	between	between	ADP
bjp-69267	203	4	gut	gut	NOUN
bjp-69267	203	5	microbiome	microbiome	NOUN
bjp-69267	203	6	bioenergetics	bioenergetic	NOUN
bjp-69267	203	7	and	and	CCONJ
bjp-69267	203	8	chronic	chronic	ADJ
bjp-69267	203	9	metabolic	metabolic	NOUN
bjp-69267	203	10	diseases	disease	NOUN
bjp-69267	203	11	.	.	PUNCT
bjp-69267	204	1	cell	cell	NOUN
bjp-69267	204	2	rep	rep	PROPN
bjp-69267	204	3	.	.	PROPN
bjp-69267	204	4	2021	2021	NUM
bjp-69267	204	5	;	;	PUNCT
bjp-69267	204	6	37	37	NUM
bjp-69267	204	7	:	:	SYM
bjp-69267	204	8	110087	110087	NUM
bjp-69267	204	9	-	-	SYM
bjp-69267	204	10	106	106	NUM
bjp-69267	204	11	.	.	PUNCT
bjp-69267	205	1	ebenezer	ebenezer	PROPN
bjp-69267	205	2	o	o	PROPN
bjp-69267	205	3	,	,	PUNCT
bjp-69267	205	4	shapi	shapi	PROPN
bjp-69267	205	5	m	m	PROPN
bjp-69267	205	6	,	,	PUNCT
bjp-69267	205	7	tuszynski	tuszynski	PROPN
bjp-69267	205	8	ja	ja	PROPN
bjp-69267	205	9	.	.	PUNCT
bjp-69267	206	1	a	a	DET
bjp-69267	206	2	review	review	NOUN
bjp-69267	206	3	of	of	ADP
bjp-69267	206	4	the	the	DET
bjp-69267	206	5	recent	recent	ADJ
bjp-69267	206	6	development	development	NOUN
bjp-69267	206	7	in	in	ADP
bjp-69267	206	8	the	the	DET
bjp-69267	206	9	synthesis	synthesis	NOUN
bjp-69267	206	10	and	and	CCONJ
bjp-69267	206	11	biological	biological	ADJ
bjp-69267	206	12	evaluations	evaluation	NOUN
bjp-69267	206	13	of	of	ADP
bjp-69267	206	14	pyrazole	pyrazole	NOUN
bjp-69267	206	15	derivatives	derivative	NOUN
bjp-69267	206	16	.	.	PUNCT
bjp-69267	207	1	biomedicines	biomedicine	VERB
bjp-69267	207	2	2022	2022	NUM
bjp-69267	207	3	;	;	PUNCT
bjp-69267	207	4	10	10	NUM
bjp-69267	207	5	:	:	SYM
bjp-69267	207	6	1124	1124	NUM
bjp-69267	207	7	-	-	SYM
bjp-69267	207	8	81	81	NUM
bjp-69267	207	9	.	.	PUNCT
bjp-69267	208	1	ignatov	ignatov	PROPN
bjp-69267	208	2	i.	i.	PROPN
bjp-69267	208	3	antimicrobial	antimicrobial	ADJ
bjp-69267	208	4	activity	activity	NOUN
bjp-69267	208	5	of	of	ADP
bjp-69267	208	6	colloidal	colloidal	NOUN
bjp-69267	208	7	nanosilver	nanosilver	ADV
bjp-69267	208	8	24	24	NUM
bjp-69267	208	9	ppm	ppm	NOUN
bjp-69267	208	10	in	in	ADP
bjp-69267	208	11	vitro	vitro	X
bjp-69267	208	12	.	.	PUNCT
bjp-69267	209	1	bulg	bulg	VERB
bjp-69267	209	2	chem	chem	PROPN
bjp-69267	209	3	commun	commun	PROPN
bjp-69267	209	4	.	.	PUNCT
bjp-69267	209	5	2021	2021	NUM
bjp-69267	209	6	;	;	PUNCT
bjp-69267	209	7	53	53	NUM
bjp-69267	209	8	:	:	SYM
bjp-69267	209	9	365	365	NUM
bjp-69267	209	10	-	-	SYM
bjp-69267	209	11	70	70	NUM
bjp-69267	209	12	.	.	PUNCT
bjp-69267	210	1	ji	ji	PROPN
bjp-69267	210	2	c	c	PROPN
bjp-69267	210	3	,	,	PUNCT
bjp-69267	210	4	svensson	svensson	PROPN
bjp-69267	210	5	f	f	PROPN
bjp-69267	210	6	,	,	PUNCT
bjp-69267	210	7	zoufir	zoufir	PROPN
bjp-69267	210	8	a	a	PRON
bjp-69267	210	9	,	,	PUNCT
bjp-69267	210	10	bender	bender	PROPN
bjp-69267	210	11	a.	a.	NOUN
bjp-69267	210	12	emoltox	emoltox	PROPN
bjp-69267	210	13	:	:	PUNCT
bjp-69267	210	14	prediction	prediction	NOUN
bjp-69267	210	15	of	of	ADP
bjp-69267	210	16	molecular	molecular	ADJ
bjp-69267	210	17	toxicity	toxicity	NOUN
bjp-69267	210	18	with	with	ADP
bjp-69267	210	19	confidence	confidence	NOUN
bjp-69267	210	20	.	.	PUNCT
bjp-69267	211	1	bioinformatics	bioinformatic	NOUN
bjp-69267	211	2	2018	2018	NUM
bjp-69267	211	3	;	;	PUNCT
bjp-69267	211	4	34	34	NUM
bjp-69267	211	5	:	:	SYM
bjp-69267	211	6	2508	2508	NUM
bjp-69267	211	7	-	-	SYM
bjp-69267	211	8	09	09	NUM
bjp-69267	211	9	.	.	PUNCT
bjp-69267	212	1	kleandrova	kleandrova	PROPN
bjp-69267	212	2	vv	vv	PROPN
bjp-69267	212	3	,	,	PUNCT
bjp-69267	212	4	speck	speck	NOUN
bjp-69267	212	5	-	-	PUNCT
bjp-69267	212	6	planche	planche	NOUN
bjp-69267	212	7	a.	a.	NOUN
bjp-69267	212	8	the	the	DET
bjp-69267	212	9	qsar	qsar	NOUN
bjp-69267	212	10	paradigm	paradigm	NOUN
bjp-69267	212	11	in	in	ADP
bjp-69267	212	12	fragment	fragment	NOUN
bjp-69267	212	13	-	-	PUNCT
bjp-69267	212	14	based	base	VERB
bjp-69267	212	15	drug	drug	NOUN
bjp-69267	212	16	discovery	discovery	NOUN
bjp-69267	212	17	:	:	PUNCT
bjp-69267	212	18	from	from	ADP
bjp-69267	212	19	the	the	DET
bjp-69267	212	20	virtual	virtual	ADJ
bjp-69267	212	21	generation	generation	NOUN
bjp-69267	212	22	of	of	ADP
bjp-69267	212	23	target	target	NOUN
bjp-69267	212	24	inhibitors	inhibitor	NOUN
bjp-69267	212	25	to	to	ADP
bjp-69267	212	26	multi	multi	ADJ
bjp-69267	212	27	-	-	ADJ
bjp-69267	212	28	scale	scale	ADJ
bjp-69267	212	29	modeling	modeling	NOUN
bjp-69267	212	30	.	.	PUNCT
bjp-69267	213	1	mini	mini	PROPN
bjp-69267	213	2	rev	rev	PROPN
bjp-69267	213	3	med	med	PROPN
bjp-69267	213	4	chem	chem	NOUN
bjp-69267	213	5	.	.	PUNCT
bjp-69267	214	1	2020	2020	NUM
bjp-69267	214	2	;	;	PUNCT
bjp-69267	214	3	20	20	NUM
bjp-69267	214	4	:	:	SYM
bjp-69267	214	5	1357	1357	NUM
bjp-69267	214	6	-	-	SYM
bjp-69267	214	7	74	74	NUM
bjp-69267	214	8	.	.	PUNCT
bjp-69267	215	1	kumar	kumar	PROPN
bjp-69267	215	2	k	k	PROPN
bjp-69267	215	3	,	,	PUNCT
bjp-69267	215	4	anbarasu	anbarasu	VERB
bjp-69267	215	5	a	a	X
bjp-69267	215	6	,	,	PUNCT
bjp-69267	215	7	ramaiah	ramaiah	PROPN
bjp-69267	215	8	s.	s.	PROPN
bjp-69267	215	9	molecular	molecular	ADJ
bjp-69267	215	10	docking	docking	NOUN
bjp-69267	215	11	and	and	CCONJ
bjp-69267	215	12	molecular	molecular	ADJ
bjp-69267	215	13	dynamics	dynamic	NOUN
bjp-69267	215	14	studies	study	NOUN
bjp-69267	215	15	on	on	ADP
bjp-69267	215	16	β	β	NOUN
bjp-69267	215	17	-	-	NOUN
bjp-69267	215	18	lactamases	lactamase	NOUN
bjp-69267	215	19	and	and	CCONJ
bjp-69267	215	20	penicillin	penicillin	NOUN
bjp-69267	215	21	binding	bind	VERB
bjp-69267	215	22	proteins	protein	NOUN
bjp-69267	215	23	.	.	PUNCT
bjp-69267	216	1	mol	mol	ADP
bjp-69267	216	2	biosyst	biosyst	NOUN
bjp-69267	216	3	.	.	PUNCT
bjp-69267	217	1	2014	2014	NUM
bjp-69267	217	2	;	;	PUNCT
bjp-69267	217	3	10	10	NUM
bjp-69267	217	4	:	:	PUNCT
bjp-69267	217	5	891	891	NUM
bjp-69267	217	6	-	-	SYM
bjp-69267	217	7	900	900	NUM
bjp-69267	217	8	.	.	PUNCT
bjp-69267	218	1	lake	lake	PROPN
bjp-69267	218	2	km	km	PROPN
bjp-69267	218	3	,	,	PUNCT
bjp-69267	218	4	rankin	rankin	PROPN
bjp-69267	218	5	sc	sc	PROPN
bjp-69267	218	6	,	,	PUNCT
bjp-69267	218	7	rosenkrantz	rosenkrantz	PROPN
bjp-69267	218	8	ws	ws	PROPN
bjp-69267	218	9	,	,	PUNCT
bjp-69267	218	10	sastry	sastry	PROPN
bjp-69267	218	11	l	l	PROPN
bjp-69267	218	12	,	,	PUNCT
bjp-69267	218	13	jacob	jacob	PROPN
bjp-69267	218	14	m	m	PROPN
bjp-69267	218	15	,	,	PUNCT
bjp-69267	218	16	campos	campos	PROPN
bjp-69267	218	17	dd	dd	PROPN
bjp-69267	218	18	,	,	PUNCT
bjp-69267	218	19	maddock	maddock	PROPN
bjp-69267	218	20	k	k	PROPN
bjp-69267	218	21	,	,	PUNCT
bjp-69267	218	22	cole	cole	PROPN
bjp-69267	218	23	sd	sd	PROPN
bjp-69267	218	24	.	.	PUNCT
bjp-69267	219	1	in	in	ADP
bjp-69267	219	2	vitro	vitro	X
bjp-69267	219	3	efficacy	efficacy	NOUN
bjp-69267	219	4	of	of	ADP
bjp-69267	219	5	0.2	0.2	NUM
bjp-69267	219	6	%	%	NOUN
bjp-69267	219	7	and	and	CCONJ
bjp-69267	219	8	0.4	0.4	NUM
bjp-69267	219	9	%	%	NOUN
bjp-69267	219	10	sodium	sodium	NOUN
bjp-69267	219	11	oxychlorosene	oxychlorosene	ADJ
bjp-69267	219	12	against	against	ADP
bjp-69267	219	13	meticillin‐resistant	meticillin‐resistant	ADJ
bjp-69267	219	14	staphylococcus	staphylococcus	NOUN
bjp-69267	219	15	pseudintermedius	pseudintermedius	NOUN
bjp-69267	219	16	.	.	PUNCT
bjp-69267	220	1	vet	vet	NOUN
bjp-69267	220	2	dermatol	dermatol	NOUN
bjp-69267	220	3	.	.	PUNCT
bjp-69267	221	1	2023	2023	NUM
bjp-69267	221	2	;	;	PUNCT
bjp-69267	221	3	34	34	NUM
bjp-69267	221	4	:	:	SYM
bjp-69267	221	5	3339	3339	NUM
bjp-69267	221	6	.	.	PUNCT
bjp-69267	222	1	li	li	PROPN
bjp-69267	222	2	b	b	PROPN
bjp-69267	222	3	,	,	PUNCT
bjp-69267	222	4	webster	webster	PROPN
bjp-69267	222	5	tj	tj	PROPN
bjp-69267	222	6	.	.	PROPN
bjp-69267	222	7	bacteria	bacteria	NOUN
bjp-69267	222	8	antibiotic	antibiotic	ADJ
bjp-69267	222	9	resistance	resistance	NOUN
bjp-69267	222	10	:	:	PUNCT
bjp-69267	222	11	new	new	ADJ
bjp-69267	222	12	challenges	challenge	NOUN
bjp-69267	222	13	and	and	CCONJ
bjp-69267	222	14	opportunities	opportunity	NOUN
bjp-69267	222	15	for	for	ADP
bjp-69267	222	16	implant‐associated	implant‐associate	VERB
bjp-69267	222	17	orthopedic	orthopedic	ADJ
bjp-69267	222	18	infections	infection	NOUN
bjp-69267	222	19	.	.	PUNCT
bjp-69267	223	1	j	j	PROPN
bjp-69267	223	2	orthop	orthop	PROPN
bjp-69267	223	3	res	re	NOUN
bjp-69267	223	4	.	.	PUNCT
bjp-69267	223	5	2018	2018	NUM
bjp-69267	223	6	;	;	PUNCT
bjp-69267	223	7	36	36	NUM
bjp-69267	223	8	:	:	SYM
bjp-69267	223	9	22	22	NUM
bjp-69267	223	10	-	-	SYM
bjp-69267	223	11	32	32	NUM
bjp-69267	223	12	.	.	PUNCT
bjp-69267	224	1	lipinski	lipinski	PROPN
bjp-69267	224	2	b.	b.	PROPN
bjp-69267	224	3	pathophysiology	pathophysiology	PROPN
bjp-69267	224	4	of	of	ADP
bjp-69267	224	5	oxidative	oxidative	ADJ
bjp-69267	224	6	stress	stress	NOUN
bjp-69267	224	7	in	in	ADP
bjp-69267	224	8	diabetes	diabetes	NOUN
bjp-69267	224	9	mellitus	mellitus	NOUN
bjp-69267	224	10	.	.	PUNCT
bjp-69267	225	1	j	j	PROPN
bjp-69267	225	2	diabetes	diabetes	PROPN
bjp-69267	225	3	complicat	complicat	PROPN
bjp-69267	225	4	.	.	PUNCT
bjp-69267	225	5	2021	2021	NUM
bjp-69267	225	6	;	;	PUNCT
bjp-69267	225	7	15	15	NUM
bjp-69267	225	8	:	:	SYM
bjp-69267	225	9	203	203	NUM
bjp-69267	225	10	-	-	SYM
bjp-69267	225	11	10	10	NUM
bjp-69267	225	12	.	.	PUNCT
bjp-69267	226	1	liu	liu	PROPN
bjp-69267	226	2	z.	z.	PROPN
bjp-69267	226	3	principal	principal	PROPN
bjp-69267	226	4	component	component	NOUN
bjp-69267	226	5	analysis	analysis	NOUN
bjp-69267	226	6	and	and	CCONJ
bjp-69267	226	7	normal	normal	ADJ
bjp-69267	226	8	mode	mode	NOUN
bjp-69267	226	9	analysis	analysis	NOUN
bjp-69267	226	10	of	of	ADP
bjp-69267	226	11	elastic	elastic	ADJ
bjp-69267	226	12	network	network	NOUN
bjp-69267	226	13	models	model	NOUN
bjp-69267	226	14	and	and	CCONJ
bjp-69267	226	15	their	their	PRON
bjp-69267	226	16	applications	application	NOUN
bjp-69267	226	17	to	to	ADP
bjp-69267	226	18	myosin	myosin	NOUN
bjp-69267	226	19	motor	motor	NOUN
bjp-69267	226	20	proteins	protein	NOUN
bjp-69267	226	21	.	.	PUNCT
bjp-69267	227	1	doctoral	doctoral	ADJ
bjp-69267	227	2	dissertation	dissertation	NOUN
bjp-69267	227	3	.	.	PUNCT
bjp-69267	228	1	wayne	wayne	PROPN
bjp-69267	228	2	state	state	PROPN
bjp-69267	228	3	university	university	PROPN
bjp-69267	228	4	.	.	PUNCT
bjp-69267	229	1	2022	2022	NUM
bjp-69267	229	2	,	,	PUNCT
bjp-69267	229	3	pp	pp	ADP
bjp-69267	229	4	2023	2023	NUM
bjp-69267	229	5	.	.	PUNCT
bjp-69267	230	1	lópez	lópez	PROPN
bjp-69267	230	2	-	-	PUNCT
bjp-69267	230	3	blanco	blanco	PROPN
bjp-69267	230	4	jr	jr	PROPN
bjp-69267	230	5	,	,	PUNCT
bjp-69267	230	6	aliaga	aliaga	PROPN
bjp-69267	230	7	ji	ji	PROPN
bjp-69267	230	8	,	,	PUNCT
bjp-69267	230	9	quintana	quintana	ADJ
bjp-69267	230	10	-	-	PUNCT
bjp-69267	230	11	ortí	ortí	NOUN
bjp-69267	230	12	es	es	NOUN
bjp-69267	230	13	.	.	PUNCT
bjp-69267	230	14	chacón	chacón	PROPN
bjp-69267	230	15	p.	p.	PROPN
bjp-69267	230	16	imods	imods	PROPN
bjp-69267	230	17	:	:	PUNCT
bjp-69267	230	18	internal	internal	ADJ
bjp-69267	230	19	coordinates	coordinate	NOUN
bjp-69267	230	20	normal	normal	ADJ
bjp-69267	230	21	mode	mode	NOUN
bjp-69267	230	22	analysis	analysis	NOUN
bjp-69267	230	23	server	server	NOUN
bjp-69267	230	24	.	.	PUNCT
bjp-69267	231	1	nucleic	nucleic	ADJ
bjp-69267	231	2	acids	acid	NOUN
bjp-69267	231	3	res	re	NOUN
bjp-69267	231	4	.	.	PUNCT
bjp-69267	231	5	2014	2014	NUM
bjp-69267	231	6	;	;	PUNCT
bjp-69267	231	7	42(w1	42(w1	NUM
bjp-69267	231	8	):	):	PUNCT
bjp-69267	231	9	w271	w271	PROPN
bjp-69267	231	10	-	-	PUNCT
bjp-69267	231	11	76	76	NUM
bjp-69267	231	12	.	.	PUNCT
bjp-69267	232	1	may	may	AUX
bjp-69267	232	2	a	a	PRON
bjp-69267	232	3	,	,	PUNCT
bjp-69267	232	4	zacharias	zacharias	PROPN
bjp-69267	232	5	m.	m.	PROPN
bjp-69267	232	6	energy	energy	NOUN
bjp-69267	232	7	minimization	minimization	NOUN
bjp-69267	232	8	in	in	ADP
bjp-69267	232	9	low‐frequency	low‐frequency	PROPN
bjp-69267	232	10	normal	normal	ADJ
bjp-69267	232	11	modes	mode	NOUN
bjp-69267	232	12	to	to	PART
bjp-69267	232	13	efficiently	efficiently	ADV
bjp-69267	232	14	allow	allow	VERB
bjp-69267	232	15	for	for	ADP
bjp-69267	232	16	global	global	ADJ
bjp-69267	232	17	flexibility	flexibility	NOUN
bjp-69267	232	18	during	during	ADP
bjp-69267	232	19	systematic	systematic	ADJ
bjp-69267	232	20	protein	protein	NOUN
bjp-69267	232	21	–	–	PUNCT
bjp-69267	232	22	protein	protein	NOUN
bjp-69267	232	23	docking	docking	NOUN
bjp-69267	232	24	.	.	PUNCT
bjp-69267	233	1	proteins	protein	NOUN
bjp-69267	233	2	:	:	PUNCT
bjp-69267	233	3	struct	struct	VERB
bjp-69267	233	4	funct	funct	ADJ
bjp-69267	233	5	bioinf	bioinf	NOUN
bjp-69267	233	6	.	.	PUNCT
bjp-69267	234	1	2008	2008	NUM
bjp-69267	234	2	;	;	PUNCT
bjp-69267	235	1	70	70	NUM
bjp-69267	235	2	:	:	PUNCT
bjp-69267	235	3	794	794	NUM
bjp-69267	235	4	-	-	PUNCT
bjp-69267	235	5	809	809	NUM
bjp-69267	235	6	.	.	PUNCT
bjp-69267	236	1	mishra	mishra	PROPN
bjp-69267	236	2	sk	sk	PROPN
bjp-69267	236	3	,	,	PUNCT
bjp-69267	236	4	jernigan	jernigan	PROPN
bjp-69267	236	5	rl	rl	PROPN
bjp-69267	236	6	.	.	PUNCT
bjp-69267	236	7	protein	protein	NOUN
bjp-69267	236	8	dynamic	dynamic	ADJ
bjp-69267	236	9	communities	community	NOUN
bjp-69267	236	10	from	from	ADP
bjp-69267	236	11	elastic	elastic	ADJ
bjp-69267	236	12	network	network	NOUN
bjp-69267	236	13	models	model	NOUN
bjp-69267	236	14	align	align	VERB
bjp-69267	236	15	closely	closely	ADV
bjp-69267	236	16	to	to	ADP
bjp-69267	236	17	the	the	DET
bjp-69267	236	18	communities	community	NOUN
bjp-69267	236	19	defined	define	VERB
bjp-69267	236	20	by	by	ADP
bjp-69267	236	21	molecular	molecular	ADJ
bjp-69267	236	22	dynamics	dynamic	NOUN
bjp-69267	236	23	.	.	PUNCT
bjp-69267	237	1	plos	plos	PROPN
bjp-69267	237	2	one	one	NUM
bjp-69267	237	3	.	.	PUNCT
bjp-69267	237	4	2018	2018	NUM
bjp-69267	237	5	;	;	PUNCT
bjp-69267	237	6	13	13	NUM
bjp-69267	237	7	:	:	PUNCT
bjp-69267	237	8	e0199225	e0199225	PROPN
bjp-69267	237	9	.	.	PUNCT
bjp-69267	238	1	pardridge	pardridge	PROPN
bjp-69267	238	2	wm	wm	PROPN
bjp-69267	238	3	.	.	PROPN
bjp-69267	238	4	drug	drug	NOUN
bjp-69267	238	5	transport	transport	NOUN
bjp-69267	238	6	across	across	ADP
bjp-69267	238	7	the	the	DET
bjp-69267	238	8	blood	blood	NOUN
bjp-69267	238	9	–	–	PUNCT
bjp-69267	238	10	brain	brain	NOUN
bjp-69267	238	11	barrier	barrier	NOUN
bjp-69267	238	12	.	.	PUNCT
bjp-69267	239	1	j	j	PROPN
bjp-69267	239	2	cereb	cereb	PROPN
bjp-69267	239	3	blood	blood	NOUN
bjp-69267	239	4	flow	flow	NOUN
bjp-69267	239	5	metab	metab	NOUN
bjp-69267	239	6	.	.	PUNCT
bjp-69267	240	1	2012	2012	NUM
bjp-69267	240	2	;	;	PUNCT
bjp-69267	240	3	32	32	NUM
bjp-69267	240	4	:	:	SYM
bjp-69267	240	5	1959	1959	NUM
bjp-69267	240	6	-	-	SYM
bjp-69267	240	7	72	72	NUM
bjp-69267	240	8	.	.	PUNCT
bjp-69267	240	9	quezada	quezada	PROPN
bjp-69267	240	10	ag	ag	PROPN
bjp-69267	240	11	,	,	PUNCT
bjp-69267	240	12	díaz	díaz	NOUN
bjp-69267	240	13	-	-	PUNCT
bjp-69267	240	14	salazar	salazar	NOUN
bjp-69267	240	15	aj	aj	PROPN
bjp-69267	240	16	,	,	PUNCT
bjp-69267	240	17	cabrera	cabrera	PROPN
bjp-69267	240	18	n	n	CCONJ
bjp-69267	240	19	,	,	PUNCT
bjp-69267	240	20	perez	perez	PROPN
bjp-69267	240	21	-	-	PUNCT
bjp-69267	240	22	montfort	montfort	NOUN
bjp-69267	240	23	r	r	NOUN
bjp-69267	240	24	,	,	PUNCT
bjp-69267	240	25	pineiro	pineiro	VERB
bjp-69267	240	26	a	a	PRON
bjp-69267	240	27	,	,	PUNCT
bjp-69267	240	28	costas	costas	PROPN
bjp-69267	240	29	m.	m.	NOUN
bjp-69267	240	30	interplay	interplay	NOUN
bjp-69267	240	31	between	between	ADP
bjp-69267	240	32	protein	protein	NOUN
bjp-69267	240	33	thermal	thermal	ADJ
bjp-69267	240	34	flexibility	flexibility	NOUN
bjp-69267	240	35	and	and	CCONJ
bjp-69267	240	36	kinetic	kinetic	ADJ
bjp-69267	240	37	stability	stability	NOUN
bjp-69267	240	38	.	.	PUNCT
bjp-69267	241	1	structure	structure	NOUN
bjp-69267	241	2	2017	2017	NUM
bjp-69267	241	3	;	;	PUNCT
bjp-69267	241	4	25	25	NUM
bjp-69267	241	5	:	:	SYM
bjp-69267	241	6	167	167	NUM
bjp-69267	241	7	-	-	SYM
bjp-69267	241	8	79	79	NUM
bjp-69267	241	9	.	.	PUNCT
bjp-69267	242	1	rani	rani	PROPN
bjp-69267	242	2	m	m	PROPN
bjp-69267	242	3	,	,	PUNCT
bjp-69267	242	4	yusuf	yusuf	PROPN
bjp-69267	242	5	m	m	PROPN
bjp-69267	242	6	,	,	PUNCT
bjp-69267	242	7	khan	khan	PROPN
bjp-69267	242	8	sa	sa	PROPN
bjp-69267	242	9	.	.	PUNCT
bjp-69267	242	10	synthesis	synthesis	NOUN
bjp-69267	242	11	and	and	CCONJ
bjp-69267	242	12	in	in	ADP
bjp-69267	242	13	-	-	PUNCT
bjp-69267	242	14	vitro	vitro	VERB
bjp-69267	242	15	-	-	PUNCT
bjp-69267	242	16	antibacterial	antibacterial	ADJ
bjp-69267	242	17	activity	activity	NOUN
bjp-69267	242	18	of	of	ADP
bjp-69267	242	19	[	[	X
bjp-69267	242	20	5-(furan-2	5-(furan-2	NUM
bjp-69267	242	21	-	-	PUNCT
bjp-69267	242	22	yl)-phenyl]-4,5	yl)-phenyl]-4,5	NUM
bjp-69267	242	23	-	-	PUNCT
bjp-69267	242	24	carbothioamide	carbothioamide	NOUN
bjp-69267	242	25	-	-	PUNCT
bjp-69267	242	26	pyrazolines	pyrazoline	NOUN
bjp-69267	242	27	.	.	PUNCT
bjp-69267	243	1	j	j	PROPN
bjp-69267	243	2	saudi	saudi	ADJ
bjp-69267	243	3	chem	chem	NOUN
bjp-69267	243	4	soc	soc	NOUN
bjp-69267	243	5	.	.	PUNCT
bjp-69267	244	1	2012	2012	NUM
bjp-69267	244	2	;	;	PUNCT
bjp-69267	244	3	16	16	NUM
bjp-69267	244	4	:	:	PUNCT
bjp-69267	244	5	431	431	NUM
bjp-69267	244	6	-	-	SYM
bjp-69267	244	7	36	36	NUM
bjp-69267	244	8	.	.	PUNCT
bjp-69267	245	1	rattanasuk	rattanasuk	NOUN
bjp-69267	245	2	s	s	PART
bjp-69267	245	3	,	,	PUNCT
bjp-69267	245	4	boongapim	boongapim	PROPN
bjp-69267	245	5	r	r	NOUN
bjp-69267	245	6	,	,	PUNCT
bjp-69267	245	7	phiwthong	phiwthong	ADJ
bjp-69267	245	8	t.	t.	ADJ
bjp-69267	245	9	antibacterial	antibacterial	ADJ
bjp-69267	245	10	activity	activity	NOUN
bjp-69267	245	11	of	of	ADP
bjp-69267	245	12	cathormion	cathormion	NOUN
bjp-69267	245	13	umbellatum	umbellatum	NOUN
bjp-69267	245	14	.	.	PUNCT
bjp-69267	246	1	bangladesh	bangladesh	PROPN
bjp-69267	246	2	j	j	PROPN
bjp-69267	246	3	pharmacol	pharmacol	PROPN
bjp-69267	246	4	.	.	PROPN
bjp-69267	246	5	2021	2021	NUM
bjp-69267	246	6	;	;	PUNCT
bjp-69267	246	7	16	16	NUM
bjp-69267	246	8	:	:	SYM
bjp-69267	246	9	91	91	NUM
bjp-69267	246	10	-	-	SYM
bjp-69267	246	11	95	95	NUM
bjp-69267	246	12	.	.	PUNCT
bjp-69267	247	1	rossiter	rossiter	PROPN
bjp-69267	247	2	se	se	PROPN
bjp-69267	247	3	,	,	PUNCT
bjp-69267	247	4	fletcher	fletcher	PROPN
bjp-69267	247	5	mh	mh	PROPN
bjp-69267	247	6	,	,	PUNCT
bjp-69267	247	7	wuest	wu	ADJ
bjp-69267	247	8	wm	wm	PROPN
bjp-69267	247	9	.	.	PROPN
bjp-69267	247	10	natural	natural	ADJ
bjp-69267	247	11	products	product	NOUN
bjp-69267	247	12	as	as	ADP
bjp-69267	247	13	platforms	platform	NOUN
bjp-69267	247	14	to	to	PART
bjp-69267	247	15	overcome	overcome	VERB
bjp-69267	247	16	antibiotic	antibiotic	ADJ
bjp-69267	247	17	resistance	resistance	NOUN
bjp-69267	247	18	.	.	PUNCT
bjp-69267	248	1	chem	chem	PROPN
bjp-69267	248	2	rev	rev	VERB
bjp-69267	248	3	.	.	PROPN
bjp-69267	248	4	2017	2017	NUM
bjp-69267	248	5	;	;	PUNCT
bjp-69267	248	6	117	117	NUM
bjp-69267	248	7	:	:	SYM
bjp-69267	248	8	12415	12415	NUM
bjp-69267	248	9	-	-	SYM
bjp-69267	248	10	74	74	NUM
bjp-69267	248	11	.	.	PUNCT
bjp-69267	249	1	sehmi	sehmi	PROPN
bjp-69267	249	2	a	a	PRON
bjp-69267	249	3	,	,	PUNCT
bjp-69267	249	4	ouici	ouici	PROPN
bjp-69267	249	5	h	h	NOUN
bjp-69267	249	6	,	,	PUNCT
bjp-69267	249	7	guendouzi	guendouzi	PROPN
bjp-69267	249	8	a	a	PROPN
bjp-69267	249	9	,	,	PUNCT
bjp-69267	249	10	ferhat	ferhat	PROPN
bjp-69267	249	11	m	m	PROPN
bjp-69267	249	12	,	,	PUNCT
bjp-69267	249	13	benali	benali	PROPN
bjp-69267	249	14	o	o	PROPN
bjp-69267	249	15	,	,	PUNCT
bjp-69267	249	16	boudjellal	boudjellal	VERB
bjp-69267	249	17	fjjs	fjjs	NOUN
bjp-69267	249	18	.	.	PUNCT
bjp-69267	250	1	corrosion	corrosion	NOUN
bjp-69267	250	2	inhibition	inhibition	NOUN
bjp-69267	250	3	of	of	ADP
bjp-69267	250	4	mild	mild	ADJ
bjp-69267	250	5	steel	steel	NOUN
bjp-69267	250	6	by	by	ADP
bjp-69267	250	7	newly	newly	ADV
bjp-69267	250	8	synthesized	synthesize	VERB
bjp-69267	250	9	pyrazole	pyrazole	NOUN
bjp-69267	250	10	carboxamide	carboxamide	NOUN
bjp-69267	250	11	derivatives	derivative	NOUN
bjp-69267	250	12	in	in	ADP
bjp-69267	250	13	hcl	hcl	PROPN
bjp-69267	250	14	acid	acid	PROPN
bjp-69267	250	15	medium	medium	NOUN
bjp-69267	250	16	:	:	PUNCT
bjp-69267	250	17	experimental	experimental	ADJ
bjp-69267	250	18	and	and	CCONJ
bjp-69267	250	19	theoretical	theoretical	ADJ
bjp-69267	250	20	studies	study	NOUN
bjp-69267	250	21	.	.	PUNCT
bjp-69267	251	1	j	j	PROPN
bjp-69267	251	2	electrochem	electrochem	PROPN
bjp-69267	251	3	soc	soc	PROPN
bjp-69267	251	4	.	.	PUNCT
bjp-69267	252	1	2020	2020	NUM
bjp-69267	252	2	;	;	PUNCT
bjp-69267	252	3	167	167	NUM
bjp-69267	252	4	:	:	SYM
bjp-69267	252	5	155508	155508	NUM
bjp-69267	252	6	-	-	SYM
bjp-69267	252	7	27	27	NUM
bjp-69267	252	8	.	.	PUNCT
bjp-69267	253	1	sumera	sumera	NOUN
bjp-69267	253	2	f	f	NOUN
bjp-69267	253	3	,	,	PUNCT
bjp-69267	253	4	anwer	anwer	NOUN
bjp-69267	253	5	m	m	PROPN
bjp-69267	253	6	,	,	PUNCT
bjp-69267	253	7	waseem	waseem	PROPN
bjp-69267	253	8	a	a	PROPN
bjp-69267	253	9	,	,	PUNCT
bjp-69267	253	10	fatima	fatima	PROPN
bjp-69267	253	11	n	n	CCONJ
bjp-69267	253	12	,	,	PUNCT
bjp-69267	253	13	malik	malik	PROPN
bjp-69267	253	14	a	a	PROPN
bjp-69267	253	15	,	,	PUNCT
bjp-69267	253	16	ali	ali	PROPN
bjp-69267	253	17	,	,	PUNCT
bjp-69267	253	18	zahid	zahid	PROPN
bjp-69267	253	19	a.	a.	PROPN
bjp-69267	253	20	molecular	molecular	ADJ
bjp-69267	253	21	docking	docking	NOUN
bjp-69267	253	22	and	and	CCONJ
bjp-69267	253	23	molecular	molecular	ADJ
bjp-69267	253	24	dynamics	dynamic	NOUN
bjp-69267	253	25	studies	study	NOUN
bjp-69267	253	26	reveal	reveal	VERB
bjp-69267	253	27	secretory	secretory	ADJ
bjp-69267	253	28	proteins	protein	NOUN
bjp-69267	253	29	as	as	ADP
bjp-69267	253	30	novel	novel	ADJ
bjp-69267	253	31	targets	target	NOUN
bjp-69267	253	32	of	of	ADP
bjp-69267	253	33	temozolomide	temozolomide	NOUN
bjp-69267	253	34	in	in	ADP
bjp-69267	253	35	glioblastoma	glioblastoma	NOUN
bjp-69267	253	36	multiforme	multiforme	NOUN
bjp-69267	253	37	.	.	PUNCT
bjp-69267	254	1	molecules	molecule	NOUN
bjp-69267	254	2	2022	2022	NUM
bjp-69267	254	3	;	;	PUNCT
bjp-69267	254	4	27	27	NUM
bjp-69267	254	5	:	:	SYM
bjp-69267	254	6	7198	7198	NUM
bjp-69267	254	7	-	-	SYM
bjp-69267	254	8	214	214	NUM
bjp-69267	254	9	.	.	PUNCT
bjp-69267	255	1	sun	sun	PROPN
bjp-69267	255	2	z	z	PROPN
bjp-69267	255	3	,	,	PUNCT
bjp-69267	255	4	liu	liu	PROPN
bjp-69267	255	5	q	q	PROPN
bjp-69267	255	6	,	,	PUNCT
bjp-69267	255	7	qu	qu	PROPN
bjp-69267	255	8	g	g	PROPN
bjp-69267	255	9	,	,	PUNCT
bjp-69267	255	10	feng	feng	PROPN
bjp-69267	255	11	y	y	PROPN
bjp-69267	255	12	,	,	PUNCT
bjp-69267	255	13	reetz	reetz	PROPN
bjp-69267	255	14	mt	mt	PROPN
bjp-69267	255	15	.	.	PROPN
bjp-69267	255	16	utility	utility	NOUN
bjp-69267	255	17	of	of	ADP
bjp-69267	255	18	b	b	NOUN
bjp-69267	255	19	-	-	PUNCT
bjp-69267	255	20	factors	factor	NOUN
bjp-69267	255	21	in	in	ADP
bjp-69267	255	22	protein	protein	NOUN
bjp-69267	255	23	science	science	NOUN
bjp-69267	255	24	:	:	PUNCT
bjp-69267	255	25	interpreting	interpret	VERB
bjp-69267	255	26	rigidity	rigidity	NOUN
bjp-69267	255	27	,	,	PUNCT
bjp-69267	255	28	flexibility	flexibility	NOUN
bjp-69267	255	29	,	,	PUNCT
bjp-69267	255	30	and	and	CCONJ
bjp-69267	255	31	internal	internal	ADJ
bjp-69267	255	32	motion	motion	NOUN
bjp-69267	255	33	and	and	CCONJ
bjp-69267	255	34	engineering	engineering	NOUN
bjp-69267	255	35	thermostability	thermostability	NOUN
bjp-69267	255	36	.	.	PUNCT
bjp-69267	256	1	chem	chem	PROPN
bjp-69267	256	2	.	.	PUNCT
bjp-69267	257	1	rev	rev	PROPN
bjp-69267	257	2	.	.	PROPN
bjp-69267	257	3	2019	2019	NUM
bjp-69267	257	4	;	;	PUNCT
bjp-69267	257	5	119	119	NUM
bjp-69267	257	6	:	:	SYM
bjp-69267	257	7	1626	1626	NUM
bjp-69267	257	8	-	-	SYM
bjp-69267	257	9	65	65	NUM
bjp-69267	257	10	.	.	PUNCT
bjp-69267	258	1	sundar	sundar	PROPN
bjp-69267	258	2	rdv	rdv	PROPN
bjp-69267	258	3	,	,	PUNCT
bjp-69267	258	4	arunachalam	arunachalam	PROPN
bjp-69267	258	5	s.	s.	PROPN
bjp-69267	258	6	effect	effect	NOUN
bjp-69267	258	7	of	of	ADP
bjp-69267	258	8	endophytic	endophytic	ADJ
bjp-69267	258	9	fungi	fungi	PROPN
bjp-69267	258	10	daldinia	daldinia	PROPN
bjp-69267	258	11	eschscholtzii	eschscholtzii	PROPN
bjp-69267	258	12	against	against	ADP
bjp-69267	258	13	multidrug	multidrug	NOUN
bjp-69267	258	14	resistant	resistant	ADJ
bjp-69267	258	15	pathogens	pathogen	NOUN
bjp-69267	258	16	.	.	PUNCT
bjp-69267	259	1	bangladesh	bangladesh	PROPN
bjp-69267	259	2	j	j	PROPN
bjp-69267	259	3	pharmacol	pharmacol	PROPN
bjp-69267	259	4	.	.	PUNCT
bjp-69267	260	1	2023	2023	NUM
bjp-69267	260	2	;	;	PUNCT
bjp-69267	260	3	18	18	NUM
bjp-69267	260	4	:	:	SYM
bjp-69267	260	5	17	17	NUM
bjp-69267	260	6	-	-	SYM
bjp-69267	260	7	23	23	NUM
bjp-69267	260	8	.	.	PUNCT
bjp-69267	261	1	szczepankiewicz	szczepankiewicz	PROPN
bjp-69267	261	2	f	f	NOUN
bjp-69267	261	3	,	,	PUNCT
bjp-69267	261	4	van	van	PROPN
bjp-69267	261	5	westen	westen	NOUN
bjp-69267	261	6	d	d	PROPN
bjp-69267	261	7	,	,	PUNCT
bjp-69267	261	8	englund	englund	PROPN
bjp-69267	261	9	e	e	PROPN
bjp-69267	261	10	,	,	PUNCT
bjp-69267	261	11	westin	westin	PROPN
bjp-69267	261	12	cf	cf	PROPN
bjp-69267	261	13	,	,	PUNCT
bjp-69267	261	14	ståhlberg	ståhlberg	PROPN
bjp-69267	261	15	j	j	PROPN
bjp-69267	261	16	,	,	PUNCT
bjp-69267	261	17	lätt	lätt	PROPN
bjp-69267	261	18	pc	pc	PROPN
bjp-69267	261	19	.	.	PUNCT
bjp-69267	262	1	sundgren	sundgren	PROPN
bjp-69267	262	2	and	and	CCONJ
bjp-69267	262	3	m.	m.	PROPN
bjp-69267	262	4	nilsson	nilsson	PROPN
bjp-69267	262	5	.	.	PUNCT
bjp-69267	263	1	the	the	DET
bjp-69267	263	2	link	link	NOUN
bjp-69267	263	3	between	between	ADP
bjp-69267	263	4	diffusion	diffusion	NOUN
bjp-69267	263	5	mri	mri	NOUN
bjp-69267	263	6	and	and	CCONJ
bjp-69267	263	7	tumor	tumor	NOUN
bjp-69267	263	8	heterogeneity	heterogeneity	NOUN
bjp-69267	263	9	:	:	PUNCT
bjp-69267	263	10	mapping	mapping	NOUN
bjp-69267	263	11	cell	cell	NOUN
bjp-69267	263	12	eccentricity	eccentricity	NOUN
bjp-69267	263	13	and	and	CCONJ
bjp-69267	263	14	density	density	NOUN
bjp-69267	263	15	by	by	ADP
bjp-69267	263	16	diffusional	diffusional	ADJ
bjp-69267	263	17	variance	variance	NOUN
bjp-69267	263	18	decomposition	decomposition	NOUN
bjp-69267	263	19	(	(	PUNCT
bjp-69267	263	20	divide	divide	NOUN
bjp-69267	263	21	)	)	PUNCT
bjp-69267	263	22	.	.	PUNCT
bjp-69267	264	1	neuroimage	neuroimage	NOUN
bjp-69267	264	2	2016	2016	NUM
bjp-69267	264	3	;	;	PUNCT
bjp-69267	264	4	142	142	NUM
bjp-69267	264	5	:	:	PUNCT
bjp-69267	264	6	522	522	NUM
bjp-69267	264	7	-	-	SYM
bjp-69267	264	8	32	32	NUM
bjp-69267	264	9	.	.	PUNCT
bjp-69267	265	1	trott	trott	PROPN
bjp-69267	265	2	o	o	PROPN
bjp-69267	265	3	,	,	PUNCT
bjp-69267	265	4	olson	olson	PROPN
bjp-69267	265	5	aj	aj	PROPN
bjp-69267	265	6	.	.	PROPN
bjp-69267	265	7	autodock	autodock	PROPN
bjp-69267	265	8	vina	vina	PROPN
bjp-69267	265	9	:	:	PUNCT
bjp-69267	265	10	improving	improve	VERB
bjp-69267	265	11	the	the	DET
bjp-69267	265	12	speed	speed	NOUN
bjp-69267	265	13	and	and	CCONJ
bjp-69267	265	14	accuracy	accuracy	NOUN
bjp-69267	265	15	of	of	ADP
bjp-69267	265	16	docking	docking	NOUN
bjp-69267	265	17	with	with	ADP
bjp-69267	265	18	a	a	DET
bjp-69267	265	19	new	new	ADJ
bjp-69267	265	20	scoring	scoring	NOUN
bjp-69267	265	21	function	function	NOUN
bjp-69267	265	22	,	,	PUNCT
bjp-69267	265	23	efficient	efficient	ADJ
bjp-69267	265	24	optimization	optimization	NOUN
bjp-69267	265	25	,	,	PUNCT
bjp-69267	265	26	and	and	CCONJ
bjp-69267	265	27	multithreading	multithreading	NOUN
bjp-69267	265	28	.	.	PUNCT
bjp-69267	266	1	j	j	PROPN
bjp-69267	266	2	comput	comput	PROPN
bjp-69267	266	3	chem	chem	PROPN
bjp-69267	266	4	.	.	PUNCT
bjp-69267	267	1	2010	2010	NUM
bjp-69267	267	2	;	;	PUNCT
bjp-69267	268	1	31	31	NUM
bjp-69267	268	2	:	:	SYM
bjp-69267	268	3	455	455	NUM
bjp-69267	268	4	-	-	SYM
bjp-69267	268	5	61	61	NUM
bjp-69267	268	6	.	.	PUNCT
bjp-69267	268	7	vică	vică	NOUN
bjp-69267	268	8	ml	ml	ADP
bjp-69267	268	9	,	,	PUNCT
bjp-69267	268	10	glevitzky	glevitzky	PROPN
bjp-69267	268	11	m	m	PROPN
bjp-69267	268	12	,	,	PUNCT
bjp-69267	268	13	tit	tit	PROPN
bjp-69267	268	14	dm	dm	PROPN
bjp-69267	268	15	,	,	PUNCT
bjp-69267	268	16	behl	behl	PROPN
bjp-69267	268	17	t	t	PROPN
bjp-69267	268	18	,	,	PUNCT
bjp-69267	268	19	heghedűş	heghedűş	NOUN
bjp-69267	268	20	-	-	PUNCT
bjp-69267	268	21	mîndru	mîndru	PROPN
bjp-69267	268	22	rc	rc	PROPN
bjp-69267	268	23	,	,	PUNCT
bjp-69267	268	24	zaha	zaha	PROPN
bjp-69267	268	25	dc	dc	PROPN
bjp-69267	268	26	,	,	PUNCT
bjp-69267	268	27	ursu	ursu	PROPN
bjp-69267	268	28	f	f	NOUN
bjp-69267	268	29	,	,	PUNCT
bjp-69267	268	30	popa	popa	NOUN
bjp-69267	268	31	m	m	PROPN
bjp-69267	268	32	,	,	PUNCT
bjp-69267	268	33	glevitzky	glevitzky	PROPN
bjp-69267	268	34	i	i	PRON
bjp-69267	268	35	,	,	PUNCT
bjp-69267	268	36	bungău	bungău	VERB
bjp-69267	268	37	s.	s.	PROPN
bjp-69267	268	38	the	the	DET
bjp-69267	268	39	antimicrobial	antimicrobial	ADJ
bjp-69267	268	40	activity	activity	NOUN
bjp-69267	268	41	of	of	ADP
bjp-69267	268	42	honey	honey	NOUN
bjp-69267	268	43	and	and	CCONJ
bjp-69267	268	44	propolis	propolis	NOUN
bjp-69267	268	45	extracts	extract	NOUN
bjp-69267	268	46	from	from	ADP
bjp-69267	268	47	the	the	DET
bjp-69267	268	48	central	central	ADJ
bjp-69267	268	49	region	region	NOUN
bjp-69267	268	50	of	of	ADP
bjp-69267	268	51	romania	romania	PROPN
bjp-69267	268	52	.	.	PUNCT
bjp-69267	268	53	2021	2021	NUM
bjp-69267	268	54	;	;	PUNCT
bjp-69267	268	55	food	food	PROPN
bjp-69267	268	56	biosci	biosci	PROPN
bjp-69267	268	57	.	.	PUNCT
bjp-69267	269	1	41	41	NUM
bjp-69267	269	2	:	:	PUNCT
bjp-69267	269	3	101	101	NUM
bjp-69267	269	4	-	-	SYM
bjp-69267	269	5	14	14	NUM
bjp-69267	269	6	.	.	PUNCT
bjp-69267	269	7	wan‐mohtar	wan‐mohtar	PROPN
bjp-69267	269	8	waaqi	waaqi	PROPN
bjp-69267	269	9	,	,	PUNCT
bjp-69267	269	10	ibrahim	ibrahim	PROPN
bjp-69267	269	11	mf	mf	VERB
bjp-69267	269	12	,	,	PUNCT
bjp-69267	269	13	rasdi	rasdi	PROPN
bjp-69267	269	14	nw	nw	PROPN
bjp-69267	269	15	,	,	PUNCT
bjp-69267	269	16	zainorahim	zainorahim	PRON
bjp-69267	269	17	n	n	CCONJ
bjp-69267	269	18	,	,	PUNCT
bjp-69267	269	19	taufek	taufek	NOUN
bjp-69267	269	20	nm	nm	VERB
bjp-69267	269	21	.	.	PUNCT
bjp-69267	270	1	microorganisms	microorganism	NOUN
bjp-69267	270	2	as	as	ADP
bjp-69267	270	3	a	a	DET
bjp-69267	270	4	sustainable	sustainable	ADJ
bjp-69267	270	5	aquafeed	aquafeed	NOUN
bjp-69267	270	6	ingredient	ingredient	NOUN
bjp-69267	270	7	:	:	PUNCT
bjp-69267	270	8	a	a	DET
bjp-69267	270	9	review	review	NOUN
bjp-69267	270	10	.	.	PUNCT
bjp-69267	271	1	aquac	aquac	PROPN
bjp-69267	271	2	.	.	PUNCT
bjp-69267	272	1	res	re	NOUN
bjp-69267	272	2	.	.	PUNCT
bjp-69267	272	3	2022	2022	NUM
bjp-69267	272	4	;	;	PUNCT
bjp-69267	272	5	53	53	NUM
bjp-69267	272	6	:	:	SYM
bjp-69267	272	7	746	746	NUM
bjp-69267	272	8	-	-	SYM
bjp-69267	272	9	66	66	NUM
bjp-69267	272	10	.	.	PUNCT
bjp-69267	273	1	zelelew	zelelew	PROPN
bjp-69267	273	2	d	d	PROPN
bjp-69267	273	3	,	,	PUNCT
bjp-69267	273	4	endale	endale	NOUN
bjp-69267	273	5	m	m	PROPN
bjp-69267	273	6	,	,	PUNCT
bjp-69267	273	7	melaku	melaku	PROPN
bjp-69267	273	8	y	y	PROPN
bjp-69267	273	9	,	,	PUNCT
bjp-69267	273	10	kedir	kedir	PROPN
bjp-69267	273	11	f	f	X
bjp-69267	273	12	,	,	PUNCT
bjp-69267	273	13	demissie	demissie	ADJ
bjp-69267	273	14	tb	tb	NOUN
bjp-69267	273	15	,	,	PUNCT
bjp-69267	273	16	ombito	ombito	PROPN
bjp-69267	273	17	jo	jo	PROPN
bjp-69267	273	18	,	,	PUNCT
bjp-69267	273	19	eswaramoorthy	eswaramoorthy	PROPN
bjp-69267	273	20	r.	r.	PROPN
bjp-69267	273	21	synthesis	synthesis	PROPN
bjp-69267	273	22	,	,	PUNCT
bjp-69267	273	23	antibacterial	antibacterial	ADJ
bjp-69267	273	24	,	,	PUNCT
bjp-69267	273	25	and	and	CCONJ
bjp-69267	273	26	antioxidant	antioxidant	ADJ
bjp-69267	273	27	activities	activity	NOUN
bjp-69267	273	28	of	of	ADP
bjp-69267	273	29	thiazolyl	thiazolyl	NOUN
bjp-69267	273	30	-	-	PUNCT
bjp-69267	273	31	pyrazoline	pyrazoline	NOUN
bjp-69267	273	32	schiff	schiff	NOUN
bjp-69267	273	33	base	base	NOUN
bjp-69267	273	34	hybrids	hybrid	NOUN
bjp-69267	273	35	:	:	PUNCT
bjp-69267	273	36	a	a	DET
bjp-69267	273	37	combined	combined	ADJ
bjp-69267	273	38	experimental	experimental	ADJ
bjp-69267	273	39	and	and	CCONJ
bjp-69267	273	40	computational	computational	ADJ
bjp-69267	273	41	study	study	NOUN
bjp-69267	273	42	.	.	PUNCT
bjp-69267	274	1	j	j	PROPN
bjp-69267	274	2	chem	chem	NOUN
bjp-69267	274	3	.	.	PUNCT
bjp-69267	275	1	2022	2022	NUM
bjp-69267	275	2	;	;	PUNCT
bjp-69267	275	3	2022	2022	NUM
bjp-69267	275	4	.	.	PUNCT
bjp-69267	276	1	bangladesh	bangladesh	PROPN
bjp-69267	276	2	j	j	PROPN
bjp-69267	276	3	pharmacol	pharmacol	PROPN
bjp-69267	276	4	2023	2023	NUM
bjp-69267	276	5	;	;	PUNCT
bjp-69267	276	6	18	18	NUM
bjp-69267	276	7	:	:	SYM
bjp-69267	276	8	152	152	NUM
bjp-69267	276	9	-	-	SYM
bjp-69267	276	10	161	161	NUM
bjp-69267	276	11	161	161	NUM