Bangladesh Journal of Pharmacology Volume: 10; Number 3; Year 2015 Cite this article as: Khan A, Khan RA, Ahmed M, Mushtaq N. Antioxidant and antifungal activities of selected fruits of Districts Bannu and Lakki Marwat, Pakistan. Bangladesh J Pharmacol. 2015; 10: 566-67. Antioxidant and antifungal activities of selected fruits of Districts Bannu and Lakki Marwat, Pakistan Sir, Scientific research done during the last century has proven the pharmacological activities of many plant parts (Cheruvanky et al., 2000). The majority of current research is directed toward the discovery of commercially useful compounds from medicinal plants and their parts (Vermani and Garg, 2002). It is estimated that 80% of the global population depend on plant derived medicines to address their health care needs (Thaipong et al., 2006). Present study is aimed to evaluate antifungal and anti- oxidants activity of Archis hypogeal, Phoenix dactylifera and Vitis vinifera. Two fifty gram powder from each of the samples were taken and placed in the 70% commercial grade metha- nol and stirred well, then after passing of 72 hours the extracts were filtered by using qualitative Whatman filter paper. In wise bath the filtrate was placed at 40°C and thus the entire methanol was evaporated, so the crude extract of the plant fruits were obtained and stored in the refrigerator at 4°C for the purpose of future in vitro studies. DPPH assays of sample fruits were performed accor-ding to the procedure as reported by Gyamfi et al. (1999) with some modifications. The antifungal activity of the fruits methanol extracts of A. hypogea, P. dactyl-lifera and V. vinifera were screened through the agar tube dilution method by using the protocol of Duraipandiyan and Ignacimuthu (2009). The scavenging results were observed during scavenging of free radicles viz; 76.1 ± 0.03% of V. vinifera, 72.0 ± 0.0% of A. hypogea and 79.0 ± 0.0% of P. dactylifera against DPPH at 500 μg/mL were obtained as shown in Table I. 40.7% inhibition of Vitis vinifera against Aspergillus flavus, 26.4% inhibition of Arachis hypogea against Aspergillus niger and 50.7% inhibition of Phoenix dactylifera against Aspergillus niger were recorded as shown in Table II. Arif Khan, Rahmat Ali Khan, Mushtaq Ahmed and Nadia Mushtaq Department of Biotechnology, University of Science and Technology, Bannu 28100, Pakistan. Corresponding author: Rahmatgul_81@yahoo.com References Cheruvanky H, McPeak P, Cherukuri RSV, Lynch IE. Method for treating hypercholesterolemia, hyperlipidemia and A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2015; 10: 566-567 Journal homepage: www.banglajol.info Abstracted/indexed in Academic Search Complete, Agroforestry Abstracts, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index ISSN: 1991-0088; DOI: 10.3329/bjp.v10i3.23269 Letter to the Editor Table I DPPH free radicals scavenging activity of fruit methanol extracts Concentration Free radicals scavenging activity (mean ± SD) Archis hypogea Phoenix dactylifera Vitis vinifera Ascorbic acid 50 μg/mL 16.1 ± 0.2 21.1 ± 0.2 22.4 ± 0.1 52.0 ± 0.0 100 μg/mL 28.0 ± 0.1 42.0 ± 0.1 32.0 ± 0.2 72.0 ± 0.1 150 μg/mL 42.0 ± 0.1 56.0 ± 0.1 48.2 ± 1.0 80.0 ± 0.0 200 μg/mL 52.0 ± 0.1 64.0 ± 0.0 56.0 ± 0.1 83.0 ± 0.0 250 μg/mL 62.0 ± 0.0 70.1 ± 0.2 65.0 ± 0.0 86.1 ± 0.0 500 μg/mL 72.0 ± 0.0 79.0 ± 0.0 76.1 ± 0.0 90.1 ± 0.1 Table II Antifungal activity of methanol extract of Archis hypogeal, Phoenix dactylifera and Vitis vinifera % inhibition Aspergillus niger Aspergillus flavius Archis hypogea 26.4 ± 0.0 20.0 ± 0.0 Phoenix dactylifera 50.7 ± 0.0 41.0 ± 0.0 Vitis vinifera 38.0 ± 0.0 40.7 ± 0.0 Terbinafine 99.4 ± 5.5 98.1 ± 3.7 mailto:mrkhanqau@yahoo.com https://www.google.com/search?tbo=p&tbm=pts&hl=en&q=ininventor:%22Patricia+McPeak%22 https://www.google.com/search?tbo=p&tbm=pts&hl=en&q=ininventor:%22Reddy+Sastry+V.+Cherukuri%22 https://www.google.com/search?tbo=p&tbm=pts&hl=en&q=ininventor:%22Ike+E.+Lynch%22 artherosclerosis. 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