id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
bptjm-71	Bentolila, Gabriela; Agrawal, Niharika ; Julie Phung; Van, Linh; Trivedi, Gatik	Exploring the Role of Senescent Cells in Neurodegenerative Pathology: A Window Into Promising Therapeutic Avenues	2024	34	.pdf	application/pdf	10517	534	42	Research comparing biomarkers of senescence in young and aged mouse brains has shown that senescent cells increase with age, along with a rise in SASP factor genes.1 Consequently, this contributes to decreased tissue regeneration and increased neuroinflammation, paving the way for neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's, and multiple sclerosis. The main function of SASP is to recruit immune cells for tissue damage repair; however, an abundance of senescent cells has a negative effect on tissue restoration and leads to a chronic, low-grade inflammation called “inflammaging”.8 Activation of inflammaging results in decreased clearance of senescent cells, establishing a positive feedback mechanism that ultimately further fuels inflammaging.	cache/bptjm-71.pdf	txt/bptjm-71.txt