bptjm: A Pathfinder

This is a computer-generated pathfinder created against the Distant Reader study called bptjm.

Each Distant Reader study carrel is composed of many individual items. Each item is bibliographically described with author, title, date, summary, and keyword values. Below is a list of the items' most signficant keywords as well as lists of the items themselves. Purpusing the content of this pathfinder provides the student, researcher, or scholar with one way to get their heads around the scope of the carrel. The keywords include:

Pharma; Treatment; Brain; Cells; Cancer; Risk; Covid-19

Depending on how this pathfinder was created, many of the bibliographic sections will include elaborations on the meaning(s) of the given keywords. These elaborations were generated by feeding the items' summaries to a large langauge model and asking the model to address the question, "What is X?", where "X" is the keyword. The result will be a few sentences of elaboration. Be forewarned. The elaborations are often plausible, but they should not be take as truth. Instead, they should be taken as points for consideration.

• Traumatic Brain Injury-Induced Parkinson's Disease: an Analysis of the Potential Correlation by Sreepad, Bhavana; Khan, Maliha; Shtutin, Rochelle; Piedrafita-Ortiz, Sofia; Govindaraman, Tejaswini; Ramachandran, Neha; McMillion, Danielle; Samimi, Ariana; Sandoval, Diego (2021) - The average time until PD diagnosis was 3.1 years for TBI patients versus 3.3 years for NTT patients, and 66% of the trauma for both the TBI and NTT group was caused by falls. In addition to long-term e ects, there appears to be a short-term e ect on cognitive function in TBI patients as well. Keywords: age; berkeley; brain; cognitive; disease; gait; injury; journal; medicine; parkinson; pd patients; pharma; research; risk; study; symptoms; tbi; tbi patients; tech
• The Role of the Gut Microbiome in Neuromodulation Therapies as a Potential Treatment Adjunct for Multiple Sclerosis by Tonne, Piper; Do, Deondre; Hasan, Nabeeha; Gundapaneni, Sravya; Reddy, Ariya; Sridharan, Saadhana; Richardson, Sierra (2021) - Exosomal microRNA in plasma as a non-invasive biomarker for the recurrence of non-small cell lung cancer. MiRNA-21: a biomarker predictive for platinum-based adjuvant chemotherapy response in patients with non-small cell lung cancer. Keywords: ammatory; bacteria; berkeley; brain; cancer; cell; cell lung; gut; gut microbiome; journal; lung; lung cancer; medicine; microbiome; oncology; patients; pharma; research; role; tech; therapy; treatment; wang
• Inhibitors of Apoptosis Proteins as Potential Research Targets for Decoding the Pathological Mechanisms of Autoimmune Diseases by Philip, Kezia; Phung, Hoc Lan; Nguyen, Vanloan (2021) - Hence, distinguishing between these two types of cell death may prove crucial during pathologic evaluations. This review provides a detailed insight into the emerging discussion on the various forms of cell death and the essential roles which certain molecules play in the development and progression of autoimmune diseases. Keywords: activation; apoptosis; berkeley; caspase; cell; cell death; death; disease; doi; family; fas; iap; journal; medicine; necroptosis; necrosis; pathway; pharma; proteins; receptor; ripk1; studies; tech
• Circulating Nucleic Acids as Promising Biomarkers: A New Frontier of Personalized Medicine by Skotz, Carolyn; Thapa, Samrat; Nowak, Mary; Phung, Hoc Lan; Mamidi, Akshitha; Patel, Hetu; Ho, Mabel (2021) - Xie et al. examined the role of let-7 in detecting time of acceleration re-proliferation, a key contributor to radiotherapy failure. Multiple miRNAs can target the same gene (Wang et al., 2018). Keywords: berkeley; biomarker; cancer; cancer patients; cell; cell lung; ctdna; dna; egfr; et al; expression; journal; levels; lung; lung cancer; medicine; mirna; mutations; nsclc; nsclc patients; patients; pharma; prognosis; signi; study; survival; tech; tissue; treatment; tumor; wang
• Activation Induced Deaminase and Potential Therapeutic Avenues by Wojtara, Magda (2022) - AID expression is upregulated by in�ammatory cytokines like interferon-γ and tumor necrosis factor (TNF)-α which induces p53 mutations in in�ammatory or cancer cells. AID is expressed in more than 40% of primary human chronic lymphocytic leukemia (CLL) cases, but AID expression can be harnessed for antileukemic e�ect after inhibition of the RAD51 homologous recombination (HR) factor 4,4’-diisothiocyanatostilbene-2-2’-disulfonic acid (DIDS)16. Keywords: activation; aid; berkeley; cell; deaminase; dna; journal; medicine; pharma; switch; tech
• Neurogenesis: Gene-Based Strategies for Treating Ischemic Stroke by Hrishikesh Bhagwat; Bronstein, Sophie; Bhatt, Anar; Nguyen, Vanloan (2022) - While�stroke�continues�to�be�among�the�most�debilitating�illnesses,�current� treatments� for� stroke�are� limited�by� their�time�of�administration�and�most� notably� cannot� reverse� tissue� damage� once� it� has� occurred. � These� include� thrombolysis,� the� chemically� induced� breakdown� of� blood� clots,� and� thrombectomy,� the� surgical� removal�of� the�blood�clots�with�a�catheter4.�A� stroke� patient� must� receive� the� standard� thrombolytic� treatment,� tissue� plasminogen�activator�(tPA),�within�4�½�hours�of�onset,�and�patients�above� 80�years�of�age�must�receive�tPA�within�3�hours5.�Moreover,�tPA�comes�with� the�risk�of�hemorrhage,�neurologic�decline�and�orolingual�angioedema6,�and� its�positive�outcome� rate� is�estimated�to�be�only�43%5.�Thrombectomy�is�a� more�versatile�option�because�of�its�ability�to�treat�patients�with�a�proximal� occlusion,� unlike� thrombolysis. Keywords: aav; berkeley; blood; brain; cells; delivery; doi:10.1016; e �; et al; factor; gene; gene therapy; growth; journal; medicine; neurod1; neurogenesis; neurons; neurotrophic; pharma; recovery; stroke; tech; therapy; vectors; � ects; � �
• Gene Therapy Avenues for Chronic Obstructive Pulmonary Disease by Calendine, Jacob; Batra, Sesha; Cherfils, Jade; Said, Omar; Nguyen, Vanloan (2022) - �� Berkeley Pharma Tech Journal of Medicine Correspondence:� KBLPCPD��!HNBJM�DPN Keywords: $01% (FOF�UIFSBQZ (FOFUJDT 1VMNPOBSZ�EJTFBTF -VOHT� %FMJWFSJFT� /BOPQBSUJDMFT Submitted�.BZ��, 202���� ccepted�JVOF��� ������ 1VCMJTIFE�+VMZ��� ����� Full Open Access Creative Commons Attribution� License 4.0 Abstract Gene therapy is a growing field in research and development that may offer a long-lasting solution to several complex diseases, including chronic obstructive pulmonary disease (COPD). (FOF�5IFSBQZ�Avenues for $ISPOJD� 0CTUSVDUJWF�1VMNPOBSZ�%JTFBTF �ïw�£×ÙåØ��×âÛäÚßäÛu�¬ÛéÞ×��×èê×u�£ëÚÛ��ÞÛèÜßâéu�¨ã×è�¬×ßÚ and ¯×äâå×ä�§ÝëïÛä Background Chronic obstructive pulmonary disease, also known as COPD, is characterized as a chronic in�ammatory lung disease that causes obstructed air�ow from the lungs. Keywords: berkeley; cells; chronic; copd; delivery; gene; gene therapy; journal; lung; medicine; methods; mucus; nps; patients; pharma; pulmonary; research; tech; therapy; treatment; vectors; � �
• Novel Methods for Inducing Cardiac Tissue Regeneration Following Ischemic Injury by Chu, Nabeen; Jeyakumar, Shreya; Koo, Bon Hee; Grandhi, Uma; Nguyen, Vanloan (2022) - Novel Methods for Inducing Cardiac Tissue Regeneration Following Ischemic Injury �ïw�§×ØÛÛä��Þëu�¬ÞèÛï×�£Ûï×áëã×èu��åä�¡ÛÛ�¤ååu�®ã×� è×äÚÞßu�and ¯×äâå×ä�§ÝëïÛä Introduction Much research has been done on various approaches to gene therapy1 to treat an ischemic injury, yet few techniques have gone into clinical trials, and these seldom show success. Derived from direct lineage reprogramming via upregulation of genetic reprogramming factors, several studies have reported the generation of functional iCMs from cardiac �broblasts in both in vitro and in vivo mouse models46, 47. Keywords: berkeley; cardiac; cardiomyocytes; cells; e �; function; gene; heart; icms; injury; journal; medicine; mrna; mscs; pharma; research; stem; tech; therapy; tissue; treatment
• Reversing Type 1 Diabetes: The Magnifying Potential of Stem Cell Encapsulation by Bagherian, Ava; Jain, Anisha; Prathap, Darshita; Nguyen, Vanloan (2022) - Stem cells are marked for their capacity to di�erentiate into di�erent Berkeley Pharma Tech Journal of Medicine | 84 types of cells, creating a large supply of any of the 200+ types of human cells¹⁰, including bone marrow cells, red blood cells, nerve cells, and most importantly for our purposes, islet cells. A clinical trial currently run by the University of Alberta beginning 2021 evaluates pitfalls of islets but also solutions to islet cell transplantation¹⁹. This highly bene�cial search for higher e�ciency and safety as it pertains to current cell therapies is a major factor as to why islet cells are a great therapeutic treatment method but also why stem cells may be a better option. Keywords: berkeley; cells; devices; diabetes; encapsulation; insulin; islet; journal; medicine; pharma; sites; stem; tech; transplantation; treatment; type
• Gene Therapy for Hemophilia by Repaka, Venkata; Lomboy, Daniel; Castro, Priscilla (2022) - AAV gene therapy focuses on promoting factors VIII and IX which stop transduction and make up hemophilia19, 20. AAV Administration Re�ning administration of AAV gene therapy so as to optimize “uptake” of vectors, induce expression, provide longer-lasting e�ects, and reduce liver damage/minimize immune system e�ects. Keywords: aav; berkeley; factor; gene; gene therapy; hemophilia; patients; pharma; protein; tech; therapy; transduction; treatment; vector; viii
• Administration of Mesenchymal Stem Cells as a Therapeutic for Amyotrophic Lateral Sclerosis by Yalamanchili, Tanvi; Mohta, Saahil; Tran, Donna (2022) - MSCs have the ability to stimulate tissue repair by di�erentiating into motor neuron cells, repair damaged neurons, and rebuild the brain-to-muscle connectivity10. Stem cells are unique in their ability to migrate to damaged tissues and/or sites, stimulate tissue repair and regeneration, and di�erentiate in response to extracellular signals. Keywords: als; berkeley; cells; disease; function; glutamate; https://www.zotero.org/google-docs/?kaqxum; journal; july; mechanisms; medicine; mesenchymal; motor; motor neurons; mscs; neurons; patients; pharma; riluzole; sod1; stem; stem cells; tech; tissue
• Novel Therapeutic Strategies for Depression by Sharma, Suhina; Gostkowski, Matthew; Patel, Jay; Yang, Christina (2022) - There are in vitro, in vivo, nonclinical, and clinical/translational studies looking at the effectiveness of natural products in depression treatment. In the research article, the team was able to protect glial loss (and hence loss of glial function) in the prefrontal cortex of a mouse brain by using TKK52, demonstrating that TKK is a potential candidate for depression treatment. Keywords: antidepressant; berkeley; brain; depression; dose; effects; journal; ketamine; medicine; mood; patients; pharma; products; psilocybin; receptor; research; serotonin; tech; treatment
• Novel Genetic Therapeutic Strategies for Lewy Body Dementia by Repaka, Venkata; Sagarduy, Carlota; Trivedi, Gatik (2022) - Additionally, a study suspected there are five specific important and targeted genes from LBD patients: BIN1 and TMEM175, SNCA, APOE, and GBA- 510. When the sequences from LBD patients and control patients were compared, they found 5 consistent different genes that were among the LBD patients. Keywords: berkeley; body; brain; dementia; disease; gene; journal; lbd; lewy; medicine; patients; pharma; protein; risk; tech
• Brain-Skin Connection: Considerations for Novel Therapies for Skin Diseases by Wojtara, Magda (2022) - It has been previously established that 5-HT is a stress mediator that contributes to the effects of psychological stress on the disruption of skin homeostasis in a variety of skin diseases, including psoriasis15. This connection also establishes that psychological stress can have effects on skin including the development or exacerbation of skin diseases such as melanoma and psoriasis. Keywords: axis; brain; cells; connection; hpa; melanoma; pharma; psoriasis; skin; stress; system
• MicroRNAs as a Diagnostic Marker and a Therapeutic Target for Alzheimer’s Disease by Ugorji, William; Yang, Gayoung; Jajoo, Prakruti (2022) - A study identified the involvement of miR-195 in ApoE4-associated pathology in AD disease progression. Symptoms of cognitive impairment and memory loss are the main assessment criteria for AD patients, and differential diagnosis can be made through cerebrospinal fluid (CSF) and positron emission tomography (PET) analysis1. Keywords: alzheimer; amyloid; app; berkeley; brain; disease; expression; journal; levels; medicine; mirnas; patients; pharma; protein; role; tau; tech; therapeutic
• Novel Therapies for Post-Traumatic Stress Disorder: A Systematic Review by Popovich, Jillian; Heidari-Bigvand, Atoosa; Son, Emma; Nguyen, Vanloan (2023) - What warrants signi�cant changes in CAPS-5 scores changes with the study, though it is commonly a change of 10 points that indicates signi�cant improvement or deterioration. By 6 and 12 months, any distinct di�erences between groups had diminished, with improvements at six months no longer being signi�cant as they were at 13 weeks. Keywords: berkeley; disorder; group; hbot; journal; medicine; oxygen; participants; pharma; post; ptsd; sgb; signi; stress; studies; study; symptoms; tech; treatment
• Gene Therapy as a Promising Approach for the Underlying Causes of Autism Spectrum Disorder by Kelly An; Fadel Batal; Sonya Svyatskaya; Nguyen, Vanloan (2023) - This mostly a�ects the frontal and temporal lobes: key elements in processing language and emotion—functions commonly found to be impaired in ASD patients. This is a phenomenon also seen in ASD patients. Keywords: asd; autism; development; factors; gene; genetic; journal; mecp2; neurons; patients; pharma; therapy
• An Overview of Interdisciplinary Research and Clinical Medicine by Worrall, Sydney (2023) - The lack of Interdisciplinary Research in Clinical Medicine 3.1 Clinical Medicine Despite the fact that clinical medicine was founded on the discoveries of interdisciplinary research, and that there is a call from within the house of clinical medicine for more interdisciplinary research, there is shockingly little of it being produced. This is despite multiple calls for interdisciplinary clinical medicine research from both inside and outside the discipline. Keywords: berkeley; doi; fields; interdisciplinary; journal; medicine; pharma; research; tech; work
• Advancing Wound Healing: Innovative Pathway Strategies for Enhanced Recovery by Ghazzawi, Jowana; Yu, Crystal ; Favela, Maria (2023) - Novel targets of therapy including LncRNA XIST, IL-33, and miR-19b, are proven to be e�cient mechanisms of accelerating burn wound healing through the enhancement of cell proliferation, extracellular matrix synthesis, and the inhibition of �broblast apoptosis. Fewer studies have been conducted in-vivo to investigate the role of LncRNA XIST in burn wound healing. Keywords: burn; cells; doi; healing; il-33; injury; journal; lncrna; medicine; mir-19b; pharma; tissue; treatment; wound; xist
• Exploring Novel Neoantigen-Based Treatment Methods for Glioblastoma by Atiq, Daniyal; Alokam, Yacoub; Shah, Suraj (2023) - - Explore the mechanisms through which neoantigens can elicit an immune response against glioblastoma tumor cells. - Evaluate the e�cacy and safety of neoantigen-based vaccines in preclinical and clinical settings. 1.3. However, advancements in immunotherapeutic approaches, such as neoantigen-based vaccines, immune checkpoint blockers, and adoptive cellular therapies, have demonstrated promising e�cacy in repressing glioblastoma tumor cells. Keywords: antibodies; antigens; berkeley; cancer; cells; dna; e �; glioblastoma; journal; medicine; methods; neoantigen; patients; pharma; speci; tech; therapies; therapy; treatment; tumor; vaccines
• Investigating Stem Cell Therapy for Alzheimer's Disease: A Promising Approach by Segal, Jasmine (2024) - Stem cell therapy aims to promote the regeneration of tissues with inhibition of in�ammation, reduction of apoptosis, stimulation of angiogenesis (blood vessel formation), and cell di�erentiation, bringing a considerable amount of attention to stem cell therapy as a feasible way of treating AD patients.14.27 Additionally, issues with the procedure and basis of stem cell therapy remain unresolved, such as long-term safety of transplantation delivery systems, cell source, and donor cell responsiveness to AD-pathogenic environments.19,40 Even so, stem cell therapy will become an e�cient candidate for AD treatment due to promising results in neuron regeneration. This literature review assesses the important uses of stem cell therapy for AD patients to provide a new clinical approach for future treatment. Keywords: alzheimer; amyloid; brain; cell; disease; medicine; models; pharma; stem; stem cell; therapy; transplantation
• Exploring the Gut Microbiome - Autism Spectrum Disorder Connection: Implications for Therapeutic Interventions and Future Directions by Schaepers-Cheu, Mayumi; Patel, Mansi; Lien, Gizell; Arora, Amaaya (2024) - Experimental results showed a signi�cant decrease in Beck Depression Inventory scores, serum insulin levels, homeostasis model assessment of insulin resistance and serum hs-CRP concentrations in patients who received the probiotic supplementation as compared with the placebo, indicating that probiotic administration can have bene�cial e�ects for MDD patients. Thus, dietary changes and treatments targeting the gut microbiota, such as Microbiota Transfer Therapy (MTT), offer promising methods for treating ASD symptoms. Keywords: asd; autism; berkeley; brain; children; doi; gut; gut microbiome; health; individuals; journal; medicine; microbiota; mtt; pharma; pmid; role; spectrum; study; symptoms; tech; treatment
• Tumor Heterogeneity and Therapeutic Challenges: Exploring Approaches and Future Directions by Gonzaga, Patricia; Tukiman, Ammabel; MacMullan, Noelie; Park, Jason (2024) - It analyzes the genetic and phenotypic variations within tumor cells by distinguishing homogeneous subpopulations within a mixed group of single cells. The process by which di�erent subclones within a tumor change over time11 Factors (e.g. oxygen, nutrient availability, immune cell in�ltration) and interactions with surrounding stromal cells in the tumor microenvironment The ability of one genotype to cause di�erent phenotypes to arise in response to di�erent environments15 Causes Anything that causes more genetic mutations (e.g. limitless replicative potential10, DNA repair defects9) - Typical evolutionary processes12 - In�uenced by many factors, such as the tumor microenviron- ment, metabolism, growth factors, and mutation - Collection of tumor cells that combine to create the tumor microenvironment13 - Consists of the extracellular matrix, immune cells, and stromal cells13 - Epithelial-to- mesenchymal transition (EMT) and certain transcription factors inducing EMT (e.g. Zeb1, Twist)15 - Genetic mutations and epigenetic Berkeley Pharma Tech Journal of Medicine | 86 rate12 modi�cations E�ects - Results in genetically distinct subpopulatio ns of di�erent cells → Genetic heterogeneity - Leads to the expansion of speci�c populations of tumor cells11→ Cellular heterogeneity - Promotes angiogenesis and an environment for cancer cells to grow14 - Prevents immune cells from in�ltrating the tumor14 - In�uences surrounding cells and cancerous cells14 - Protects metastasized cancer cells from ferroptosis, a type of cell death16 - Give rise to subpopulations of tumor cells with distinct functional properties16→ Cellular heterogeneity Table 1. Keywords: berkeley; cancer; cancer cells; car; cells; combination; eats; erent; heterogeneity; journal; medicine; patients; pharma; response; speci; t cells; target; tech; therapy; treatment; tumor; tumor cells; tumor heterogeneity; types
• Neurogenetics: Precision Medicine-Based Approaches to Neurological Disorders with an Emphasis on Addressing Alzheimer’s Disease and Schizophrenia by Srinivasan, Nethra; Mehra, Eshaan; Dommaraju, Sriya; Kakavetsis, Ethan (2024) - For example, induced pluripotent stem cells (iPSC) are a type of stem cell derived from adult cells that have the potential to develop into di�erent types of cells in the body.26 These cells are created through a process called reprogramming which involves the introduction of speci�c genes into a specialized cell to reprogram it back to a state similar to that of an embryonic stem cell. Research involving diverse populations reveals varying prevalence rates of risk genes for Opioid Use Disorder (OUD) based on ethnicity, with speci�c genetic variations being linked to susceptibility in Caucasian individuals but not in African-American or Hispanic populations.4 This evidence suggests that there are larger implications in other neurogenetic diseases such as Alzheimer’s disease and Schizophrenia. Keywords: alzheimer; berkeley; cells; disease; genes; journal; medicine; pharma; precision; risk; schizophrenia; speci; symptoms; tech; treatment
• Cognitive and Mobility Enhancement through Brain-Machine Interfaces and Neuroengineering by Roshni Nandwani; Srilakshmi Palanikumar; Sahaj Sidhu Singh; Balading, Jehan Mikaela (2024) - This comprehensive literature review delves into the current state of BMI technology, emphasizing its applications in stroke rehabilitation, paralysis management, prosthetics, memory enhancement, and communication solutions for speech impairments. Moreover, affordability is a major concern, as the high cost of developing BMI technology limits its widespread adoption. Keywords: berkeley; bmis; brain; communication; computer; individuals; interfaces; journal; medicine; patients; pharma; potential; technologies; technology
• Long-Term Effects of Hormonal Oral Contraceptives on Adolescents’ Mental Health by Mythili Nair; Isabelle Pappas; Sahithi Lingala (2024) - Conclusion In conclusion, this review paper has addressed the critical issue of the long-term effects of hormonal oral contraceptives on adolescents' mental health. Body Template.docx Berkeley Pharma Tech Journal of Medicine Correspondence: mynair@ucsc.edu Keywords: oral contraceptives (OC) depression estrogen progesterone synaptic pruning prefrontal cortex hypothalamic-pituitary-adrenal (HPA) axis Submitted December 11, 2023 Accepted July 14, 2024 Published December 27, 2024 Full Open Access Creative Commons Attribution License 4.0 Abstract Adolescence is a critical stage of development marked by profound physical, emotional, and psychological changes. Keywords: adolescents; brain; contraceptives; depression; effects; estrogen; medicine; mood; pharma; risk; symptoms; use; women
• Decoding the Interplay: Exploring Immunotherapy Resistance in the Tumor Microenvironment by Kannabran, Sanchitha ; Ajan, Akshaya ; Lui, Leanne ; Yet, Zaden (2024) - While TILs e�ectively eliminate tumor cells, they can be recruited by the TME, compromising immune response e�cacy.4 Regulatory T cells (Tregs) maintain immune response balance, but when recruited to the TME, they hinder T cell formation, posing a danger to immune function. Consequently, immune mechanisms originally aimed at protecting the body now facilitate TME growth.10 NK cells surveil the bloodstream for tumor cells, inhibiting metastasis.8,9 Macrophages regulate immune responses by phagocytosing pathogens and presenting antigens. Keywords: anti; berkeley; cancer; cells; e �; immune; immunotherapy; journal; medicine; microenvironment; pd-1; pharma; resistance; response; t cells; targeting; tech; tme; tumor; tumor microenvironment
• Innovations in Pain Management: From Traditional Analgesics to Novel Therapeutic Modalities by Chang, Brandon; Hergenroeder, Danica ; Gage, Glory ; Tan, Nathan (2025) - It is a synthetic opioid that is used for pain treatment and opioid use disorders (OUD). A study conducted on the release of ketamine through PLGA nanoparticles was conducted by Han et al; biocompatible and biodegradable ketamine-loaded polyethylene-glycol - PLGA nanoparticles were tested in pain treatment in the context of pain medicine47. Keywords: berkeley; cancer; capsaicin; chronic; clinical; drug; effects; journal; lipid; medicine; nanoparticles; opioid; pain; patients; pharma; photobiomodulation; receptor; release; research; study; system; tech; tech journal; tens; therapy; tissue; treatment
• The Pulse of Cognition: Investigating Neurovascular Coupling's Role in Cognition and Therapeutic Promise for Alzheimer’s, Parkinson’s, and Dementia by Eu, Irene; Lu, Cindy; Lee, Evan ; Soni, Kalp (2025) - Effective strategies include pharmacological treatments, nutraceutical approaches, and vascular-targeted therapies aimed at addressing both the underlying causes and the consequences of cognitive decline. Collectively, these conditions underscore the multifaceted nature of cognitive decline and emphasize the need to address these diseases. Keywords: alzheimer; berkeley; blood; brain; decline; disease; health; journal; medicine; neurovascular; pharma; tech; vascular
• Preventing Schizophrenia: Insights from Epigenetic Research by Fischer-Zimmermann, Cheyenne; Shah, Khushi; Seligson, Laney; Perazzo, Noah (2025) - This approach may enhance both the prevention and management of schizophrenia by addressing underlying epigenetic vulnerabilities.16 5.2 Pharmacological Potential As the majority of schizophrenia treatments have focused on treating the dopaminergic pathway and the subsequent positive symptoms, the Berkeley Pharma Tech Journal of Medicine | 157 pharmacological potential of epigenetically adjusting abnormal levels of other neurotransmitter pathways has been overlooked. As a result, the application of epigenetic therapeutics in schizophrenia treatment remains limited, despite substantial evidence supporting its promise. Keywords: berkeley; disorder; dna; expression; gene; individuals; journal; medicine; pharma; psychosis; research; risk; schizophrenia; symptoms; tech; treatment
• Exploring the Role of Senescent Cells in Neurodegenerative Pathology: A Window Into Promising Therapeutic Avenues by Bentolila, Gabriela; Agrawal, Niharika ; Julie Phung; Van, Linh; Trivedi, Gatik (2024) - Research comparing biomarkers of senescence in young and aged mouse brains has shown that senescent cells increase with age, along with a rise in SASP factor genes.1 Consequently, this contributes to decreased tissue regeneration and increased neuroinflammation, paving the way for neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's, and multiple sclerosis. The main function of SASP is to recruit immune cells for tissue damage repair; however, an abundance of senescent cells has a negative effect on tissue restoration and leads to a chronic, low-grade inflammation called “inflammaging”.8 Activation of inflammaging results in decreased clearance of senescent cells, establishing a positive feedback mechanism that ultimately further fuels inflammaging. Keywords: aging; berkeley; brain; cells; diseases; et al; expression; factors; journal; medicine; mice; neurons; pharma; potential; protein; role; sasp; senescence; senolytics; signaling; tau; tech; treatment
• Promoting Gut Microbiome Diversity in Anorexic Patients: A Neurobiological Review by Shankar, Aditi; Wong, Hayden ; Kwe, Izabel; Wang, Luke (2025) - Firmicutes are important gut bacteria for metabolism and Bacteroidetes, while sometimes beneficial, overabundance of this species can be damaging for gut barriers as it degrades the mucus barriers of intestines.121 In addition, a study on lactating women found that those with higher Vitamin E intake were associated with a decrease in proteobacteria, known to contain many pathogens and cause inflammation.119 This supports the idea that Vitamin E deficiency can increase inflammatory response. Finally, microbes interact with enteroendocrine cells to release gut hormones and control appetite, nutrition absorption, and digestion.10 Given how gut microbiomes maintain proper metabolic and neurological functions, the symbiosis of host and microbes is crucial. Keywords: anorexia; barrier; berkeley; body; brain; diversity; eating; effects; food; gut; gut microbiome; health; intake; journal; ketone; levels; medicine; microbiome; nervosa; neurons; npy; patients; pharma; pharma tech; potential; research; role; signaling; studies; study; supplements; system; tech; tech journal; treatment; vitamin; weight
• Adolescent Brain Development Under Stress and Trauma: Evidence-Based Treatments by Pappas, Isabelle; Yu, Tzung ; Liu, Olivia ; Srinivasan, Nainika (2025) - Ultimately, studies show that adolescent stress and trauma leads to significant hormonal and morphological changes in the brain that result in psychological changes such as anxiety and depressive symptoms. 2. Morphological and Psychological Effects 2.1 Amygdala The amygdala, critical for emotional reactivity and cognitive processes such as memory, possesses a high concentration of glucocorticoid receptors that causes it to be susceptible to stress.7,8 During postnatal development, the amygdala undergoes a period of rapid growth which peaks during ages 9-11 and diminishes.9 These changes highlight the importance of the amygdala in studies regarding adolescent stress and trauma. Keywords: activity; adolescents; amygdala; anxiety; berkeley; brain; changes; childhood; cortex; development; disorder; doi:10.1016; early; effects; hippocampus; journal; medicine; neurosci; pfc; pharma; psychiatry; ptsd; rats; stress; studies; study; symptoms; tech; therapy; threat; trauma; treatments; volume; youth

• The Predictive Power of Attention-Deficit Hyperactivity Disorder (ADHD) Genetic Risk Factors by Varatip, Ashley; Huang, Serena; Kilam, Yash; Asadi, Cameron (2023) - Therefore, it can be concluded that NRXN1 de�ciency is associated with the expression of synapse-related genes and ADHD pathogenesis and can be a potential therapeutic target for ADHD treatment 15 . Published: June 30, 2023 Full Open Access Creative Commons Attribution License 4.0 Issues regarding disorganization and hyperactivity are large burdens on the pediatric population, and the severity of these behavioral disorders, called attention-deficit hyperactivity disorder (ADHD), falls on the slow-developing treatments that are unable to fully solve the symptoms of those affected. Keywords: adhd; children; dopamine; gad65; gene; january; nrxn1; patients; stimulants; treatment
• Chloroquine Defeats Aging? by Larrick, James; Larrick, Jasmine (2023) - Heme polymerase: Modulation by chloroquine treatment of a rodent malaria. Geroprotective activities of chloroquine Li et al. reported the geroprotective e�ects of low-dose CQ on aged rats 6 . Keywords: aging; autophagy; chloroquine; et al; journal; medicine; mice; studies; treatment
• Effective Reprogramming Strategies for Treating Diabetes-Related Cancer: A Focus on Fasentin, Metformin, and Panitumumab Therapies by Fang, Heyi; Guinto, Hailey; Pinneboina, Harshita (2023) - Consequently, in high glucose cancer cells, a higher glycolysis rate is present, allowing the reprogramming strategy to further promote the process and raise intracellular lactate, permitting cancer cells to poison themselves. In this article, the relationship among the chain of obesity, diabetes mellitus, and cancer development researched by di�erent articles regarding to distinct diabetes-associated cancer types is reviewed, the potential metabolic reprogramming pathways of glucose uptake and digestion by cancer cells are studied, and the mechanisms of inhibitory functions on process of reprogramming by Fasentin, Panitumumab, and Metformin are possessed for the possibility as drug treatments of diabetes-associated cancer. Keywords: breast; cancer; cells; diabetes; ect; energy; glucose; growth; insulin; journal; medicine; metabolic; metformin; tissue; treatment; tumor; vol
• Anti-Inflammatory Interventions for Autism Spectrum Disorder by Holston, Haily; Karvat, Avani ; Lallian, Simran; Wu, PingJu (2024) - Additionally, it exhibits anti-in�ammatory e�ects that can alleviate neuroin�ammation, frequently observed in individuals with autism8, 45, 46. MSCs can be transplanted directly with no genetic modi�cation, or pretreatment, can di�erentiate itself, and don’t have any signi�cant side e�ects such as tumors42. Keywords: ammation; ammatory; asd; autism; journal; neuroin; oxytocin; patients; potential; rsv; sfn; signi; social; spectrum; symptoms; therapy; treatment
• Exploring Ethical Frontiers: A Content Analysis of Perceptions Surrounding Genetic Editing in Mental Health Treatments Over Time by Vu, Kellin (2024) - For neurological diseases, the attitudes toward genetic editing technology treatment were characterized with a positive sentiment at 0.295 for the first five years of the last decade and a positive sentiment of 0.507 for the last five years. In order to establish a connection between the perceptions and patterns in attitudes supporting or against the application of genetic editing technologies and the ethical considerations of this form of healthcare treatment, it is appropriate to hypothesize that the overall trend will exhibit a positive correlation in sentiments of various polygenic diseases as time progresses over the last decade. Keywords: diseases; editing; editing technology; health; healthcare; medicine; perceptions; sentiment; study; technology; treatment

• Exploring the Intricacies of Neuroinvasive Infections: A Comprehensive Analysis of SARS-CoV-2’s Impact on the Nervous System by Obomanu, Fantasia; Woo, Emily; Adoni, Sunanya; Surada, Vedasri (2024) - By curbing viral activity, these agents make significant strides in reducing neurotoxicity, fortifying the defense against potential neurological damage. Neurological Damage Caused by SARS-CoV-2 The evidence of neurological damage caused by SARS-CoV-2 is becoming increasingly clear, as various studies have uncovered potential mechanisms underlying this damage. Keywords: brain; cov-2; covid-19; damage; infections; potential; sars; system

• The Therapeutic Potential of Synthetic and Natural Cannabinoids in Treating Alzheimer’s Disease by Kanchumarthi, Nidhi; Rockland, Avigail; Vembar, Thejaswini; Liu, Elaine; Kanaad, Rithvik; Torres Hinojosa, Erick; Tiv, Kira; Chen, Benjamin; Hao, Shira; Guttikonda, Sri; Garza, Ramiro (2021) - Uddin, M. S., Mamun, A. A., Sumsuzzman, D. M., Ashraf, G. M., Perveen, A., Bungau, S. G.,Mousa, S. A., El-Seedi, H. R., Bin-Jumah, M. N., & Abdel-Daim, M. M. (2020). Receptor Agonists A. Inhibitory Activity by Receptor Agonists Many studies have investigated the variety of proposed therapeutic treatments mediated by endocannabinoid receptor agonists, speci�cally the inhibitory activity of receptor agonists in Alzheimer’s disease. Keywords: agonists; alzheimer; cannabinoids; cb2; cbd; cells; disease; e �; endocannabinoid; et al; journal; medicine; receptors; system

• Exploring the Therapeutic Potential of PTPN Families in Lung and Digestive Cancers by Yishak, Hasset; Halwah, Kareem; Rhim, Jiyun (2023) - PTPN3 knockdown cells moved 30% faster than the control which had normal expression of PTPN3.24 4.1 EGFR Additionally, PTPN3 is able to target EGFR for lysosomal degradation inhibiting proliferation of cancer cells. Wang J, Chen X, Liu B, Zhu Z. Suppression of PTP1B in gastric cancer cells in vitro induces a change in the genome-wide expression pro�le and inhibits gastric cancer cell growth. Keywords: cancer; cell; growth; journal; levels; lung; lung cancer; pathway; protein; ptp1b; ptpn13; ptpn6; shp2; tumor

• The Mask Mandate: The Controversy Continues by Chandran, Nidhi (2022) - �� Berkeley Pharma Tech Journal of Medicine Correspondence:� OJEIJDIBOESBO��!HNBJM�DPN Keywords: COVID-19 Masks� Mask mandates Public policy SARS-CoV2 Submitted�.BZ��� ������� ccepted�JVOF��� ������ 1VCMJTIFE�+VMZ��� ����� Full Open Access Creative Commons Attribution� License 4.0 Abstract On March 11, 2020, the world came to a standstill in a truly unprecedented manner. .BTL�.BOEBUFT��5IF� $POUSPWFSTZ�$POUJOVFT �ïw�§ßÚÞß��Þ×äÚè×ä Introduction When the pandemic �rst began, much was unknown about the transmission mechanism of SARS-COV2. Keywords: april; covid-19; mask; medicine; public; risk; � �

• Interest in Telehealth for Obstetrics and Gynecology During the COVID-19 Pandemic by Wojtara, Magda; Athwal, Simran ; Adebogun, Dorcas ; Elahi, Maira (2023) - Other benefits include reduced hospital readmission and increased availability of inpatient beds for patients requiring critical care.25 Several measures were put in place to facilitate the integration of telehealth care during the pandemic; for example, due to the increasing patient load during the pandemic, several countries expanded access to telehealth using various methods such as relaxing previously strict laws regarding telehealth, which had been put in place due to ethical concerns, concerns about patient data privacy, and concerns about accountability.21 Similarly, the lack of insurance coverage for telehealth is another factor that initially limited the incorporation of telehealth into healthcare systems before the pandemic; however, insurance companies have begun reimbursing patients' costs incurred due to telehealth care delivery.21 This retrospective study using data from March 1, 2021 to March 31, 2022 evaluates the relationship between the daily reported number of new COVID-19 cases and corresponding changes to search volume on obstetrics and gynecology telehealth visits. Keywords: cases; correlation; covid-19; data; google; healthcare; interest; march; pandemic; public; rsv; search; telehealth; trends

Epilogue

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Created: 2025-12-23