id	sid	tid	token	lemma	pos
bptjm-23	1	1	berkeley	berkeley	PROPN
bptjm-23	1	2	pharma	pharma	PROPN
bptjm-23	1	3	tech	tech	NOUN
bptjm-23	1	4	journal	journal	NOUN
bptjm-23	1	5	of	of	ADP
bptjm-23	1	6	medicine	medicine	NOUN
bptjm-23	1	7	correspondence	correspondence	NOUN
bptjm-23	1	8	:	:	PUNCT
bptjm-23	1	9	�	�	PROPN
bptjm-23	1	10	kblpcpd	kblpcpd	PROPN
bptjm-23	1	11	�	�	PROPN
bptjm-23	1	12	�	�	PROPN
bptjm-23	1	13	!hnbjm	!hnbjm	PROPN
bptjm-23	1	14	�	�	PROPN
bptjm-23	1	15	dpn	dpn	PROPN
bptjm-23	1	16	keywords	keyword	NOUN
bptjm-23	1	17	:	:	PUNCT
bptjm-23	1	18	$	$	SYM
bptjm-23	1	19	01	01	NUM
bptjm-23	1	20	%	%	NOUN
bptjm-23	1	21	(	(	PUNCT
bptjm-23	1	22	fof	fof	PROPN
bptjm-23	1	23	�	�	PROPN
bptjm-23	1	24	uifsbqz	uifsbqz	NOUN
bptjm-23	1	25	(	(	PUNCT
bptjm-23	1	26	fofujdt	fofujdt	ADJ
bptjm-23	1	27	1vmnpobsz	1vmnpobsz	NUM
bptjm-23	1	28	�	�	PROPN
bptjm-23	1	29	ejtfbtf	ejtfbtf	ADJ
bptjm-23	1	30	-voht	-voht	PROPN
bptjm-23	1	31	�	�	PROPN
bptjm-23	1	32	%	%	PROPN
bptjm-23	1	33	fmjwfsjft	fmjwfsjft	PROPN
bptjm-23	1	34	�	�	PROPN
bptjm-23	1	35	/bopqbsujdmft	/bopqbsujdmft	PUNCT
bptjm-23	1	36	submitted�.bz	submitted�.bz	PROPN
bptjm-23	1	37	�	�	PROPN
bptjm-23	1	38	�	�	PROPN
bptjm-23	1	39	,	,	PUNCT
bptjm-23	1	40	202	202	NUM
bptjm-23	1	41	�	�	PROPN
bptjm-23	1	42	�	�	PROPN
bptjm-23	1	43	�	�	PROPN
bptjm-23	1	44	�	�	PROPN
bptjm-23	1	45	"	"	PUNCT
bptjm-23	1	46	ccepted	ccepte	VERB
bptjm-23	1	47	�	�	PROPN
bptjm-23	1	48	jvof	jvof	PROPN
bptjm-23	1	49	�	�	PROPN
bptjm-23	1	50	�	�	PROPN
bptjm-23	1	51	�	�	PROPN
bptjm-23	1	52	�	�	PROPN
bptjm-23	1	53	�	�	PROPN
bptjm-23	1	54	�	�	PROPN
bptjm-23	1	55	�	�	PROPN
bptjm-23	1	56	�	�	PROPN
bptjm-23	1	57	�	�	PROPN
bptjm-23	1	58	1vcmjtife	1vcmjtife	NUM
bptjm-23	1	59	�	�	PROPN
bptjm-23	1	60	+vmz	+vmz	PROPN
bptjm-23	1	61	�	�	PROPN
bptjm-23	1	62	�	�	PROPN
bptjm-23	1	63	�	�	PROPN
bptjm-23	1	64	�	�	PROPN
bptjm-23	1	65	�	�	PROPN
bptjm-23	1	66	�	�	PROPN
bptjm-23	1	67	�	�	PROPN
bptjm-23	1	68	�	�	PROPN
bptjm-23	1	69	full	full	ADJ
bptjm-23	1	70	open	open	ADJ
bptjm-23	1	71	access	access	NOUN
bptjm-23	1	72	creative	creative	ADJ
bptjm-23	1	73	commons	common	NOUN
bptjm-23	1	74	attribution	attribution	NOUN
bptjm-23	1	75	�	�	PROPN
bptjm-23	1	76	license	license	VERB
bptjm-23	1	77	4.0	4.0	NUM
bptjm-23	1	78	abstract	abstract	ADJ
bptjm-23	1	79	gene	gene	NOUN
bptjm-23	1	80	therapy	therapy	NOUN
bptjm-23	1	81	is	be	AUX
bptjm-23	1	82	a	a	DET
bptjm-23	1	83	growing	grow	VERB
bptjm-23	1	84	field	field	NOUN
bptjm-23	1	85	in	in	ADP
bptjm-23	1	86	research	research	NOUN
bptjm-23	1	87	and	and	CCONJ
bptjm-23	1	88	development	development	NOUN
bptjm-23	1	89	that	that	PRON
bptjm-23	1	90	may	may	AUX
bptjm-23	1	91	offer	offer	VERB
bptjm-23	1	92	a	a	DET
bptjm-23	1	93	long	long	ADV
bptjm-23	1	94	-	-	PUNCT
bptjm-23	1	95	lasting	last	VERB
bptjm-23	1	96	solution	solution	NOUN
bptjm-23	1	97	to	to	ADP
bptjm-23	1	98	several	several	ADJ
bptjm-23	1	99	complex	complex	ADJ
bptjm-23	1	100	diseases	disease	NOUN
bptjm-23	1	101	,	,	PUNCT
bptjm-23	1	102	including	include	VERB
bptjm-23	1	103	chronic	chronic	ADJ
bptjm-23	1	104	obstructive	obstructive	ADJ
bptjm-23	1	105	pulmonary	pulmonary	ADJ
bptjm-23	1	106	disease	disease	NOUN
bptjm-23	1	107	(	(	PUNCT
bptjm-23	1	108	copd	copd	PROPN
bptjm-23	1	109	)	)	PUNCT
bptjm-23	1	110	.	.	PUNCT
bptjm-23	2	1	copd	copd	PROPN
bptjm-23	2	2	is	be	AUX
bptjm-23	2	3	characterized	characterize	VERB
bptjm-23	2	4	by	by	ADP
bptjm-23	2	5	chronic	chronic	ADJ
bptjm-23	2	6	inflammation	inflammation	NOUN
bptjm-23	2	7	in	in	ADP
bptjm-23	2	8	the	the	DET
bptjm-23	2	9	lungs	lung	NOUN
bptjm-23	2	10	and	and	CCONJ
bptjm-23	2	11	the	the	DET
bptjm-23	2	12	airways	airway	NOUN
bptjm-23	2	13	,	,	PUNCT
bptjm-23	2	14	leading	lead	VERB
bptjm-23	2	15	to	to	ADP
bptjm-23	2	16	respiratory	respiratory	ADJ
bptjm-23	2	17	problems	problem	NOUN
bptjm-23	2	18	.	.	PUNCT
bptjm-23	3	1	copd	copd	PROPN
bptjm-23	3	2	includes	include	VERB
bptjm-23	3	3	chronic	chronic	ADJ
bptjm-23	3	4	bronchitis	bronchitis	NOUN
bptjm-23	3	5	and	and	CCONJ
bptjm-23	3	6	emphysema	emphysema	ADJ
bptjm-23	3	7	.	.	PUNCT
bptjm-23	4	1	optimizing	optimize	VERB
bptjm-23	4	2	treatments	treatment	NOUN
bptjm-23	4	3	for	for	ADP
bptjm-23	4	4	gene	gene	NOUN
bptjm-23	4	5	therapy	therapy	NOUN
bptjm-23	4	6	in	in	ADP
bptjm-23	4	7	copd	copd	PROPN
bptjm-23	4	8	is	be	AUX
bptjm-23	4	9	of	of	ADP
bptjm-23	4	10	paramount	paramount	ADJ
bptjm-23	4	11	importance	importance	NOUN
bptjm-23	4	12	given	give	VERB
bptjm-23	4	13	copd	copd	NOUN
bptjm-23	4	14	's	's	PART
bptjm-23	4	15	prominence	prominence	NOUN
bptjm-23	4	16	as	as	ADP
bptjm-23	4	17	the	the	DET
bptjm-23	4	18	fourth	fourth	ADJ
bptjm-23	4	19	leading	leading	ADJ
bptjm-23	4	20	cause	cause	NOUN
bptjm-23	4	21	of	of	ADP
bptjm-23	4	22	disease	disease	NOUN
bptjm-23	4	23	-	-	PUNCT
bptjm-23	4	24	related	relate	VERB
bptjm-23	4	25	death	death	NOUN
bptjm-23	4	26	in	in	ADP
bptjm-23	4	27	the	the	DET
bptjm-23	4	28	united	united	PROPN
bptjm-23	4	29	states	states	PROPN
bptjm-23	4	30	.	.	PUNCT
bptjm-23	5	1	we	we	PRON
bptjm-23	5	2	reviewed	review	VERB
bptjm-23	5	3	delivery	delivery	NOUN
bptjm-23	5	4	methods	method	NOUN
bptjm-23	5	5	in	in	ADP
bptjm-23	5	6	the	the	DET
bptjm-23	5	7	current	current	ADJ
bptjm-23	5	8	research	research	NOUN
bptjm-23	5	9	,	,	PUNCT
bptjm-23	5	10	including	include	VERB
bptjm-23	5	11	liposomes	liposome	NOUN
bptjm-23	5	12	,	,	PUNCT
bptjm-23	5	13	nanoparticles	nanoparticle	NOUN
bptjm-23	5	14	,	,	PUNCT
bptjm-23	5	15	electroporation	electroporation	NOUN
bptjm-23	5	16	,	,	PUNCT
bptjm-23	5	17	adeno	adeno	NOUN
bptjm-23	5	18	-	-	PUNCT
bptjm-23	5	19	viruses	virus	NOUN
bptjm-23	5	20	,	,	PUNCT
bptjm-23	5	21	and	and	CCONJ
bptjm-23	5	22	adeno	adeno	NOUN
bptjm-23	5	23	-	-	PUNCT
bptjm-23	5	24	associated	associate	VERB
bptjm-23	5	25	viruses	virus	NOUN
bptjm-23	5	26	(	(	PUNCT
bptjm-23	5	27	aav	aav	NOUN
bptjm-23	5	28	)	)	PUNCT
bptjm-23	5	29	.	.	PUNCT
bptjm-23	6	1	the	the	DET
bptjm-23	6	2	broad	broad	ADJ
bptjm-23	6	3	customizability	customizability	NOUN
bptjm-23	6	4	in	in	ADP
bptjm-23	6	5	the	the	DET
bptjm-23	6	6	diagnostic	diagnostic	ADJ
bptjm-23	6	7	and	and	CCONJ
bptjm-23	6	8	treatment	treatment	NOUN
bptjm-23	6	9	methods	method	NOUN
bptjm-23	6	10	is	be	AUX
bptjm-23	6	11	evident	evident	ADJ
bptjm-23	6	12	in	in	ADP
bptjm-23	6	13	the	the	DET
bptjm-23	6	14	recent	recent	ADJ
bptjm-23	6	15	studies	study	NOUN
bptjm-23	6	16	.	.	PUNCT
bptjm-23	7	1	in	in	ADP
bptjm-23	7	2	this	this	DET
bptjm-23	7	3	paper	paper	NOUN
bptjm-23	7	4	we	we	PRON
bptjm-23	7	5	explore	explore	VERB
bptjm-23	7	6	each	each	DET
bptjm-23	7	7	method	method	NOUN
bptjm-23	7	8	and/or	and/or	CCONJ
bptjm-23	7	9	biomarker	biomarker	VERB
bptjm-23	7	10	and	and	CCONJ
bptjm-23	7	11	evaluate	evaluate	VERB
bptjm-23	7	12	several	several	ADJ
bptjm-23	7	13	gene	gene	NOUN
bptjm-23	7	14	therapy	therapy	NOUN
bptjm-23	7	15	avenues	avenue	NOUN
bptjm-23	7	16	for	for	ADP
bptjm-23	7	17	copd	copd	NOUN
bptjm-23	7	18	.	.	PUNCT
bptjm-23	8	1	(	(	PUNCT
bptjm-23	8	2	fof	fof	PROPN
bptjm-23	8	3	�	�	PROPN
bptjm-23	8	4	5ifsbqz	5ifsbqz	NUM
bptjm-23	8	5	�	�	NOUN
bptjm-23	8	6	avenues	avenue	NOUN
bptjm-23	8	7	for	for	ADP
bptjm-23	8	8	$	$	SYM
bptjm-23	8	9	ispojd	ispojd	PROPN
bptjm-23	8	10	�	�	PROPN
bptjm-23	8	11	0ctusvdujwf	0ctusvdujwf	NUM
bptjm-23	8	12	�	�	PROPN
bptjm-23	8	13	1vmnpobsz	1vmnpobsz	NUM
bptjm-23	8	14	�	�	NOUN
bptjm-23	8	15	%jtfbtf	%jtfbtf	PROPN
bptjm-23	8	16	�	�	PROPN
bptjm-23	8	17	ïw	ïw	PROPN
bptjm-23	8	18	�	�	PROPN
bptjm-23	8	19	£×ùåø	£×ùåø	PROPN
bptjm-23	8	20	�	�	PROPN
bptjm-23	8	21	�	�	NOUN
bptjm-23	8	22	×âûäúßäûu	×âûäúßäûu	NOUN
bptjm-23	8	23	�	�	PROPN
bptjm-23	8	24	¬ûéþ×	¬ûéþ×	PROPN
bptjm-23	8	25	�	�	PROPN
bptjm-23	8	26	�	�	PROPN
bptjm-23	8	27	×èê×u	×èê×u	PROPN
bptjm-23	8	28	�	�	PROPN
bptjm-23	8	29	£ëúû	£ëúû	PROPN
bptjm-23	8	30	�	�	PROPN
bptjm-23	8	31	�	�	PROPN
bptjm-23	8	32	þûèüßâéu	þûèüßâéu	PROPN
bptjm-23	8	33	�	�	PROPN
bptjm-23	8	34	¨ã×è	¨ã×è	PROPN
bptjm-23	8	35	�	�	PROPN
bptjm-23	8	36	¬×ßú	¬×ßú	X
bptjm-23	8	37	and	and	CCONJ
bptjm-23	8	38	¯×äâå×ä	¯×äâå×ä	ADJ
bptjm-23	8	39	�	�	PROPN
bptjm-23	8	40	§ýëïûä	§ýëïûä	NOUN
bptjm-23	8	41	background	background	NOUN
bptjm-23	8	42	chronic	chronic	ADJ
bptjm-23	8	43	obstructive	obstructive	ADJ
bptjm-23	8	44	pulmonary	pulmonary	ADJ
bptjm-23	8	45	disease	disease	NOUN
bptjm-23	8	46	,	,	PUNCT
bptjm-23	8	47	also	also	ADV
bptjm-23	8	48	known	know	VERB
bptjm-23	8	49	as	as	ADP
bptjm-23	8	50	copd	copd	NOUN
bptjm-23	8	51	,	,	PUNCT
bptjm-23	8	52	is	be	AUX
bptjm-23	8	53	characterized	characterize	VERB
bptjm-23	8	54	as	as	ADP
bptjm-23	8	55	a	a	DET
bptjm-23	8	56	chronic	chronic	NOUN
bptjm-23	8	57	in	in	ADP
bptjm-23	8	58	�	�	PROPN
bptjm-23	8	59	ammatory	ammatory	NOUN
bptjm-23	8	60	lung	lung	NOUN
bptjm-23	8	61	disease	disease	NOUN
bptjm-23	8	62	that	that	PRON
bptjm-23	8	63	causes	causes	AUX
bptjm-23	8	64	obstructed	obstruct	VERB
bptjm-23	8	65	air	air	PROPN
bptjm-23	8	66	�	�	PROPN
bptjm-23	8	67	ow	ow	PROPN
bptjm-23	8	68	from	from	ADP
bptjm-23	8	69	the	the	DET
bptjm-23	8	70	lungs	lung	NOUN
bptjm-23	8	71	.	.	PUNCT
bptjm-23	9	1	it	it	PRON
bptjm-23	9	2	includes	include	VERB
bptjm-23	9	3	multiple	multiple	ADJ
bptjm-23	9	4	progressive	progressive	ADJ
bptjm-23	9	5	lung	lung	NOUN
bptjm-23	9	6	diseases	disease	NOUN
bptjm-23	9	7	that	that	SCONJ
bptjm-23	9	8	a	a	DET
bptjm-23	9	9	�	�	NOUN
bptjm-23	9	10	ect	ect	VERB
bptjm-23	9	11	millions	million	NOUN
bptjm-23	9	12	of	of	ADP
bptjm-23	9	13	people	people	NOUN
bptjm-23	9	14	yearly	yearly	ADV
bptjm-23	9	15	.	.	PUNCT
bptjm-23	10	1	in	in	ADP
bptjm-23	10	2	2018	2018	NUM
bptjm-23	10	3	,	,	PUNCT
bptjm-23	10	4	copd	copd	PROPN
bptjm-23	10	5	was	be	AUX
bptjm-23	10	6	the	the	DET
bptjm-23	10	7	fourth	fourth	ADJ
bptjm-23	10	8	leading	lead	VERB
bptjm-23	10	9	disease	disease	NOUN
bptjm-23	10	10	related	relate	VERB
bptjm-23	10	11	cause	cause	NOUN
bptjm-23	10	12	of	of	ADP
bptjm-23	10	13	death	death	NOUN
bptjm-23	10	14	in	in	ADP
bptjm-23	10	15	the	the	DET
bptjm-23	10	16	united	united	PROPN
bptjm-23	10	17	states	states	PROPN
bptjm-23	10	18	,	,	PUNCT
bptjm-23	10	19	6.4	6.4	NUM
bptjm-23	10	20	%	%	NOUN
bptjm-23	10	21	of	of	ADP
bptjm-23	10	22	americans	americans	PROPN
bptjm-23	10	23	were	be	AUX
bptjm-23	10	24	diagnosed	diagnose	VERB
bptjm-23	10	25	with	with	ADP
bptjm-23	10	26	the	the	DET
bptjm-23	10	27	disease	disease	NOUN
bptjm-23	10	28	,	,	PUNCT
bptjm-23	10	29	unfortunately	unfortunately	ADV
bptjm-23	10	30	,	,	PUNCT
bptjm-23	10	31	this	this	DET
bptjm-23	10	32	number	number	NOUN
bptjm-23	10	33	is	be	AUX
bptjm-23	10	34	likely	likely	ADV
bptjm-23	10	35	higher	high	ADJ
bptjm-23	10	36	due	due	ADJ
bptjm-23	10	37	to	to	ADP
bptjm-23	10	38	undiagnosed	undiagnosed	ADJ
bptjm-23	10	39	cases1	cases1	NOUN
bptjm-23	10	40	.	.	PUNCT
bptjm-23	11	1	figure	figure	VERB
bptjm-23	11	2	1	1	NUM
bptjm-23	11	3	:	:	PUNCT
bptjm-23	11	4	diagram	diagram	NOUN
bptjm-23	11	5	of	of	ADP
bptjm-23	11	6	the	the	DET
bptjm-23	11	7	lungs	lung	NOUN
bptjm-23	11	8	and	and	CCONJ
bptjm-23	11	9	the	the	DET
bptjm-23	11	10	effect	effect	NOUN
bptjm-23	11	11	chronic	chronic	ADJ
bptjm-23	11	12	bronchitis	bronchitis	NOUN
bptjm-23	11	13	and	and	CCONJ
bptjm-23	11	14	emphysema	emphysema	NOUN
bptjm-23	11	15	has	have	VERB
bptjm-23	11	16	on	on	ADP
bptjm-23	11	17	them	they	PRON
bptjm-23	11	18	.	.	PUNCT
bptjm-23	12	1	boxed	box	VERB
bptjm-23	12	2	under	under	ADP
bptjm-23	12	3	chronic	chronic	ADJ
bptjm-23	12	4	bronchitis	bronchitis	NOUN
bptjm-23	12	5	are	be	AUX
bptjm-23	12	6	images	image	NOUN
bptjm-23	12	7	of	of	ADP
bptjm-23	12	8	healthy	healthy	ADJ
bptjm-23	12	9	(	(	PUNCT
bptjm-23	12	10	a	a	NOUN
bptjm-23	12	11	)	)	PUNCT
bptjm-23	12	12	and	and	CCONJ
bptjm-23	12	13	unhealthy	unhealthy	ADJ
bptjm-23	12	14	(	(	PUNCT
bptjm-23	12	15	b	b	NOUN
bptjm-23	12	16	)	)	PUNCT
bptjm-23	12	17	bronchial	bronchial	ADJ
bptjm-23	12	18	tubes	tube	NOUN
bptjm-23	12	19	,	,	PUNCT
bptjm-23	12	20	(	(	PUNCT
bptjm-23	12	21	b	b	X
bptjm-23	12	22	)	)	PUNCT
bptjm-23	12	23	shows	show	VERB
bptjm-23	12	24	the	the	DET
bptjm-23	12	25	inflammation	inflammation	NOUN
bptjm-23	12	26	and	and	CCONJ
bptjm-23	12	27	increased	increase	VERB
bptjm-23	12	28	mucus	mucus	NOUN
bptjm-23	12	29	in	in	ADP
bptjm-23	12	30	the	the	DET
bptjm-23	12	31	unhealthy	unhealthy	ADJ
bptjm-23	12	32	bronchial	bronchial	ADJ
bptjm-23	12	33	tubes	tube	NOUN
bptjm-23	12	34	.	.	PUNCT
bptjm-23	13	1	boxed	box	VERB
bptjm-23	13	2	under	under	ADP
bptjm-23	13	3	emphysema	emphysema	NOUN
bptjm-23	13	4	are	be	AUX
bptjm-23	13	5	images	image	NOUN
bptjm-23	13	6	of	of	ADP
bptjm-23	13	7	the	the	DET
bptjm-23	13	8	alveoli	alveoli	NOUN
bptjm-23	13	9	,	,	PUNCT
bptjm-23	13	10	healthy	healthy	ADJ
bptjm-23	13	11	(	(	PUNCT
bptjm-23	13	12	a	a	NOUN
bptjm-23	13	13	)	)	PUNCT
bptjm-23	13	14	and	and	CCONJ
bptjm-23	13	15	unhealthy	unhealthy	ADJ
bptjm-23	13	16	(	(	PUNCT
bptjm-23	13	17	b	b	NOUN
bptjm-23	13	18	)	)	PUNCT
bptjm-23	13	19	.	.	PUNCT
bptjm-23	14	1	in	in	ADP
bptjm-23	14	2	the	the	DET
bptjm-23	14	3	unhealthy	unhealthy	ADJ
bptjm-23	14	4	(	(	PUNCT
bptjm-23	14	5	b	b	NOUN
bptjm-23	14	6	)	)	PUNCT
bptjm-23	14	7	image	image	NOUN
bptjm-23	14	8	there	there	PRON
bptjm-23	14	9	is	be	VERB
bptjm-23	14	10	a	a	DET
bptjm-23	14	11	membrane	membrane	NOUN
bptjm-23	14	12	breakdown	breakdown	NOUN
bptjm-23	14	13	due	due	ADP
bptjm-23	14	14	to	to	ADP
bptjm-23	14	15	inhaled	inhale	VERB
bptjm-23	14	16	pollutants	pollutant	NOUN
bptjm-23	14	17	that	that	PRON
bptjm-23	14	18	causes	cause	VERB
bptjm-23	14	19	larger	large	ADJ
bptjm-23	14	20	sacs	sac	NOUN
bptjm-23	14	21	with	with	ADP
bptjm-23	14	22	a	a	DET
bptjm-23	14	23	decreased	decrease	VERB
bptjm-23	14	24	surface	surface	NOUN
bptjm-23	14	25	area	area	NOUN
bptjm-23	14	26	.	.	PUNCT
bptjm-23	15	1	copd	copd	PROPN
bptjm-23	15	2	is	be	AUX
bptjm-23	15	3	not	not	PART
bptjm-23	15	4	caused	cause	VERB
bptjm-23	15	5	by	by	ADP
bptjm-23	15	6	a	a	DET
bptjm-23	15	7	single	single	ADJ
bptjm-23	15	8	gene	gene	NOUN
bptjm-23	15	9	or	or	CCONJ
bptjm-23	15	10	factor	factor	NOUN
bptjm-23	15	11	,	,	PUNCT
bptjm-23	15	12	this	this	PRON
bptjm-23	15	13	makes	make	VERB
bptjm-23	15	14	a	a	DET
bptjm-23	15	15	single	single	ADJ
bptjm-23	15	16	treatment	treatment	NOUN
bptjm-23	15	17	for	for	ADP
bptjm-23	15	18	all	all	DET
bptjm-23	15	19	patients	patient	NOUN
bptjm-23	15	20	less	less	ADJ
bptjm-23	15	21	e	e	NOUN
bptjm-23	15	22	�	�	NOUN
bptjm-23	15	23	ective	ective	ADJ
bptjm-23	15	24	,	,	PUNCT
bptjm-23	15	25	and	and	CCONJ
bptjm-23	15	26	makes	make	VERB
bptjm-23	15	27	an	an	DET
bptjm-23	15	28	appeal	appeal	NOUN
bptjm-23	15	29	towards	towards	ADP
bptjm-23	15	30	a	a	DET
bptjm-23	15	31	more	more	ADV
bptjm-23	15	32	personalized	personalized	ADJ
bptjm-23	15	33	treatment1	treatment1	NOUN
bptjm-23	15	34	.	.	PUNCT
bptjm-23	16	1	two	two	NUM
bptjm-23	16	2	of	of	ADP
bptjm-23	16	3	its	its	PRON
bptjm-23	16	4	major	major	ADJ
bptjm-23	16	5	contributors	contributor	NOUN
bptjm-23	16	6	include	include	VERB
bptjm-23	16	7	emphysema	emphysema	NOUN
bptjm-23	16	8	and	and	CCONJ
bptjm-23	16	9	chronic	chronic	ADJ
bptjm-23	16	10	bronchitis	bronchitis	NOUN
bptjm-23	16	11	.	.	PUNCT
bptjm-23	17	1	chronic	chronic	PROPN
bptjm-23	17	2	bronchitis	bronchitis	NOUN
bptjm-23	17	3	is	be	AUX
bptjm-23	17	4	characterized	characterize	VERB
bptjm-23	17	5	by	by	ADP
bptjm-23	17	6	the	the	DET
bptjm-23	17	7	in	in	ADP
bptjm-23	17	8	�	�	PROPN
bptjm-23	17	9	ammation	ammation	NOUN
bptjm-23	17	10	of	of	ADP
bptjm-23	17	11	the	the	DET
bptjm-23	17	12	bronchial	bronchial	ADJ
bptjm-23	17	13	tube	tube	NOUN
bptjm-23	17	14	lining	lining	NOUN
bptjm-23	17	15	and	and	CCONJ
bptjm-23	17	16	excess	excess	ADJ
bptjm-23	17	17	mucus	mucus	NOUN
bptjm-23	17	18	production	production	NOUN
bptjm-23	17	19	,	,	PUNCT
bptjm-23	17	20	the	the	DET
bptjm-23	17	21	bronchial	bronchial	ADJ
bptjm-23	17	22	tubes	tube	NOUN
bptjm-23	17	23	are	be	AUX
bptjm-23	17	24	responsible	responsible	ADJ
bptjm-23	17	25	for	for	ADP
bptjm-23	17	26	carrying	carry	VERB
bptjm-23	17	27	air	air	NOUN
bptjm-23	17	28	to	to	ADP
bptjm-23	17	29	and	and	CCONJ
bptjm-23	17	30	from	from	ADP
bptjm-23	17	31	the	the	DET
bptjm-23	17	32	air	air	NOUN
bptjm-23	17	33	sacs	sac	NOUN
bptjm-23	17	34	(	(	PUNCT
bptjm-23	17	35	alveoli	alveoli	NOUN
bptjm-23	17	36	)	)	PUNCT
bptjm-23	17	37	within	within	ADP
bptjm-23	17	38	the	the	DET
bptjm-23	17	39	lungs	lung	NOUN
bptjm-23	17	40	.	.	PUNCT
bptjm-23	18	1	emphysema	emphysema	PROPN
bptjm-23	18	2	is	be	AUX
bptjm-23	18	3	a	a	DET
bptjm-23	18	4	condition	condition	NOUN
bptjm-23	18	5	in	in	ADP
bptjm-23	18	6	which	which	PRON
bptjm-23	18	7	the	the	DET
bptjm-23	18	8	alveoli	alveoli	NOUN
bptjm-23	18	9	membranes	membrane	NOUN
bptjm-23	18	10	are	be	AUX
bptjm-23	18	11	destroyed	destroy	VERB
bptjm-23	18	12	due	due	ADP
bptjm-23	18	13	to	to	ADP
bptjm-23	18	14	chronically	chronically	ADV
bptjm-23	18	15	inhaled	inhaled	ADJ
bptjm-23	18	16	pollutants	pollutant	NOUN
bptjm-23	18	17	.	.	PUNCT
bptjm-23	19	1	the	the	DET
bptjm-23	19	2	membrane	membrane	NOUN
bptjm-23	19	3	breakdown	breakdown	NOUN
bptjm-23	19	4	creates	create	VERB
bptjm-23	19	5	larger	large	ADJ
bptjm-23	19	6	air	air	NOUN
bptjm-23	19	7	sacs	sac	NOUN
bptjm-23	19	8	rather	rather	ADV
bptjm-23	19	9	than	than	ADP
bptjm-23	19	10	smaller	small	ADJ
bptjm-23	19	11	ones	one	NOUN
bptjm-23	19	12	,	,	PUNCT
bptjm-23	19	13	berkeley	berkeley	PROPN
bptjm-23	19	14	pharma	pharma	PROPN
bptjm-23	19	15	tech	tech	NOUN
bptjm-23	19	16	journal	journal	NOUN
bptjm-23	19	17	of	of	ADP
bptjm-23	19	18	medicine	medicine	NOUN
bptjm-23	19	19	|	|	ADV
bptjm-23	19	20	59	59	NUM
bptjm-23	19	21	this	this	PRON
bptjm-23	19	22	decreases	decrease	VERB
bptjm-23	19	23	the	the	DET
bptjm-23	19	24	surface	surface	NOUN
bptjm-23	19	25	area	area	NOUN
bptjm-23	19	26	and	and	CCONJ
bptjm-23	19	27	the	the	DET
bptjm-23	19	28	amount	amount	NOUN
bptjm-23	19	29	of	of	ADP
bptjm-23	19	30	oxygen	oxygen	NOUN
bptjm-23	19	31	that	that	PRON
bptjm-23	19	32	can	can	AUX
bptjm-23	19	33	di	di	AUX
bptjm-23	19	34	�	�	PROPN
bptjm-23	19	35	use	use	NOUN
bptjm-23	19	36	into	into	ADP
bptjm-23	19	37	the	the	DET
bptjm-23	19	38	blood	blood	NOUN
bptjm-23	19	39	.	.	PUNCT
bptjm-23	20	1	there	there	PRON
bptjm-23	20	2	are	be	VERB
bptjm-23	20	3	many	many	ADJ
bptjm-23	20	4	factors	factor	NOUN
bptjm-23	20	5	that	that	PRON
bptjm-23	20	6	cause	cause	VERB
bptjm-23	20	7	the	the	DET
bptjm-23	20	8	development	development	NOUN
bptjm-23	20	9	and	and	CCONJ
bptjm-23	20	10	progression	progression	NOUN
bptjm-23	20	11	of	of	ADP
bptjm-23	20	12	copd	copd	NOUN
bptjm-23	20	13	,	,	PUNCT
bptjm-23	20	14	the	the	DET
bptjm-23	20	15	main	main	ADJ
bptjm-23	20	16	factors	factor	NOUN
bptjm-23	20	17	include	include	VERB
bptjm-23	20	18	cigarette	cigarette	NOUN
bptjm-23	20	19	smoke	smoke	NOUN
bptjm-23	20	20	and	and	CCONJ
bptjm-23	20	21	work	work	NOUN
bptjm-23	20	22	-	-	PUNCT
bptjm-23	20	23	related	relate	VERB
bptjm-23	20	24	pollutants2	pollutants2	NOUN
bptjm-23	20	25	.	.	PUNCT
bptjm-23	21	1	copd	copd	PROPN
bptjm-23	21	2	is	be	AUX
bptjm-23	21	3	also	also	ADV
bptjm-23	21	4	considered	consider	VERB
bptjm-23	21	5	to	to	PART
bptjm-23	21	6	be	be	AUX
bptjm-23	21	7	inheritable	inheritable	ADJ
bptjm-23	21	8	,	,	PUNCT
bptjm-23	21	9	as	as	SCONJ
bptjm-23	21	10	there	there	PRON
bptjm-23	21	11	are	be	VERB
bptjm-23	21	12	genetic	genetic	ADJ
bptjm-23	21	13	components	component	NOUN
bptjm-23	21	14	that	that	PRON
bptjm-23	21	15	can	can	AUX
bptjm-23	21	16	play	play	VERB
bptjm-23	21	17	a	a	DET
bptjm-23	21	18	role	role	NOUN
bptjm-23	21	19	in	in	ADP
bptjm-23	21	20	disease	disease	NOUN
bptjm-23	21	21	development	development	NOUN
bptjm-23	21	22	.	.	PUNCT
bptjm-23	22	1	the	the	DET
bptjm-23	22	2	�	�	PROPN
bptjm-23	22	3	rst	rst	PROPN
bptjm-23	22	4	gene	gene	NOUN
bptjm-23	22	5	identi	identi	X
bptjm-23	22	6	�	�	PROPN
bptjm-23	22	7	ed	ed	PROPN
bptjm-23	22	8	to	to	PART
bptjm-23	22	9	be	be	AUX
bptjm-23	22	10	associated	associate	VERB
bptjm-23	22	11	with	with	ADP
bptjm-23	22	12	copd	copd	PROPN
bptjm-23	22	13	was	be	AUX
bptjm-23	22	14	seroina	seroina	ADJ
bptjm-23	22	15	,	,	PUNCT
bptjm-23	22	16	which	which	PRON
bptjm-23	22	17	encodes	encode	VERB
bptjm-23	22	18	alpha1	alpha1	NOUN
bptjm-23	22	19	-	-	PUNCT
bptjm-23	22	20	antitrypsin	antitrypsin	NOUN
bptjm-23	22	21	(	(	PUNCT
bptjm-23	22	22	a1at	a1at	NOUN
bptjm-23	22	23	)	)	PUNCT
bptjm-23	22	24	.	.	PUNCT
bptjm-23	23	1	de	de	PROPN
bptjm-23	23	2	�	�	PROPN
bptjm-23	23	3	ciencies	ciencie	NOUN
bptjm-23	23	4	in	in	ADP
bptjm-23	23	5	a1at	a1at	X
bptjm-23	23	6	can	can	AUX
bptjm-23	23	7	lead	lead	VERB
bptjm-23	23	8	to	to	ADP
bptjm-23	23	9	emphysema	emphysema	NOUN
bptjm-23	23	10	,	,	PUNCT
bptjm-23	23	11	but	but	CCONJ
bptjm-23	23	12	only	only	ADV
bptjm-23	23	13	1	1	NUM
bptjm-23	23	14	-	-	SYM
bptjm-23	23	15	3	3	NUM
bptjm-23	23	16	%	%	NOUN
bptjm-23	23	17	of	of	ADP
bptjm-23	23	18	copd	copd	NOUN
bptjm-23	23	19	patients	patient	NOUN
bptjm-23	23	20	have	have	VERB
bptjm-23	23	21	the	the	DET
bptjm-23	23	22	de	de	X
bptjm-23	23	23	�	�	NOUN
bptjm-23	23	24	ciency	ciency	NOUN
bptjm-23	23	25	.	.	PUNCT
bptjm-23	24	1	additionally	additionally	ADV
bptjm-23	24	2	,	,	PUNCT
bptjm-23	24	3	it	it	PRON
bptjm-23	24	4	has	have	AUX
bptjm-23	24	5	been	be	AUX
bptjm-23	24	6	recently	recently	ADV
bptjm-23	24	7	discovered	discover	VERB
bptjm-23	24	8	that	that	SCONJ
bptjm-23	24	9	altered	alter	VERB
bptjm-23	24	10	mirna	mirna	NOUN
bptjm-23	24	11	expression	expression	NOUN
bptjm-23	24	12	in	in	ADP
bptjm-23	24	13	the	the	DET
bptjm-23	24	14	lungs	lung	NOUN
bptjm-23	24	15	might	might	AUX
bptjm-23	24	16	also	also	ADV
bptjm-23	24	17	play	play	VERB
bptjm-23	24	18	a	a	DET
bptjm-23	24	19	role	role	NOUN
bptjm-23	24	20	in	in	ADP
bptjm-23	24	21	the	the	DET
bptjm-23	24	22	copd	copd	NOUN
bptjm-23	24	23	mechanism	mechanism	NOUN
bptjm-23	24	24	.	.	PUNCT
bptjm-23	25	1	the	the	DET
bptjm-23	25	2	characteristic	characteristic	ADJ
bptjm-23	25	3	symptoms	symptom	NOUN
bptjm-23	25	4	that	that	SCONJ
bptjm-23	25	5	de	de	PROPN
bptjm-23	25	6	�	�	PROPN
bptjm-23	25	7	ne	ne	ADJ
bptjm-23	25	8	copd	copd	PROPN
bptjm-23	25	9	include	include	VERB
bptjm-23	25	10	the	the	DET
bptjm-23	25	11	following	following	NOUN
bptjm-23	25	12	:	:	PUNCT
bptjm-23	25	13	breathing	breathe	VERB
bptjm-23	25	14	di	di	PROPN
bptjm-23	25	15	�	�	PROPN
bptjm-23	25	16	culty	culty	PROPN
bptjm-23	25	17	,	,	PUNCT
bptjm-23	25	18	coughing	coughing	NOUN
bptjm-23	25	19	,	,	PUNCT
bptjm-23	25	20	wheezing	wheezing	NOUN
bptjm-23	25	21	,	,	PUNCT
bptjm-23	25	22	oxidant	oxidant	ADJ
bptjm-23	25	23	/	/	SYM
bptjm-23	25	24	antioxidant	antioxidant	ADJ
bptjm-23	25	25	imbalance	imbalance	NOUN
bptjm-23	25	26	,	,	PUNCT
bptjm-23	25	27	emphysema	emphysema	X
bptjm-23	25	28	(	(	PUNCT
bptjm-23	25	29	alveolar	alveolar	ADJ
bptjm-23	25	30	wall	wall	NOUN
bptjm-23	25	31	destruction	destruction	PROPN
bptjm-23	25	32	)	)	PUNCT
bptjm-23	25	33	,	,	PUNCT
bptjm-23	25	34	mucus	mucus	NOUN
bptjm-23	25	35	hypersecretion	hypersecretion	NOUN
bptjm-23	25	36	,	,	PUNCT
bptjm-23	25	37	enhanced	enhance	VERB
bptjm-23	25	38	cytokines	cytokine	NOUN
bptjm-23	25	39	,	,	PUNCT
bptjm-23	25	40	chemokines	chemokine	NOUN
bptjm-23	25	41	,	,	PUNCT
bptjm-23	25	42	protease	protease	NOUN
bptjm-23	25	43	,	,	PUNCT
bptjm-23	25	44	and	and	CCONJ
bptjm-23	25	45	in	in	ADP
bptjm-23	25	46	�	�	PROPN
bptjm-23	25	47	ammation3	ammation3	PROPN
bptjm-23	25	48	.	.	PUNCT
bptjm-23	26	1	current	current	ADJ
bptjm-23	26	2	conventional	conventional	ADJ
bptjm-23	26	3	therapeutic	therapeutic	ADJ
bptjm-23	26	4	strategies	strategy	NOUN
bptjm-23	26	5	of	of	ADP
bptjm-23	26	6	copd	copd	NOUN
bptjm-23	26	7	utilize	utilize	VERB
bptjm-23	26	8	antioxidant	antioxidant	NOUN
bptjm-23	26	9	and	and	CCONJ
bptjm-23	26	10	anti	anti	ADJ
bptjm-23	26	11	-	-	ADJ
bptjm-23	26	12	in	in	ADP
bptjm-23	26	13	�	�	NOUN
bptjm-23	26	14	ammatory	ammatory	NOUN
bptjm-23	26	15	drugs3	drugs3	NOUN
bptjm-23	26	16	.	.	PUNCT
bptjm-23	27	1	these	these	DET
bptjm-23	27	2	drugs	drug	NOUN
bptjm-23	27	3	tend	tend	VERB
bptjm-23	27	4	to	to	PART
bptjm-23	27	5	be	be	AUX
bptjm-23	27	6	bronchodilators	bronchodilator	NOUN
bptjm-23	27	7	,	,	PUNCT
bptjm-23	27	8	such	such	ADJ
bptjm-23	27	9	as	as	ADP
bptjm-23	27	10	β	β	NOUN
bptjm-23	27	11	-	-	NOUN
bptjm-23	27	12	agonists	agonist	NOUN
bptjm-23	27	13	and	and	CCONJ
bptjm-23	27	14	muscarinic	muscarinic	ADJ
bptjm-23	27	15	antagonists	antagonist	NOUN
bptjm-23	27	16	,	,	PUNCT
bptjm-23	27	17	and	and	CCONJ
bptjm-23	27	18	inhaled	inhaled	ADJ
bptjm-23	27	19	corticosteroids	corticosteroid	NOUN
bptjm-23	27	20	,	,	PUNCT
bptjm-23	27	21	both	both	PRON
bptjm-23	27	22	of	of	ADP
bptjm-23	27	23	which	which	PRON
bptjm-23	27	24	are	be	AUX
bptjm-23	27	25	only	only	ADV
bptjm-23	27	26	used	use	VERB
bptjm-23	27	27	for	for	ADP
bptjm-23	27	28	short	short	ADJ
bptjm-23	27	29	-	-	PUNCT
bptjm-23	27	30	term	term	NOUN
bptjm-23	27	31	management	management	NOUN
bptjm-23	27	32	.	.	PUNCT
bptjm-23	28	1	these	these	DET
bptjm-23	28	2	treatments	treatment	NOUN
bptjm-23	28	3	only	only	ADV
bptjm-23	28	4	target	target	VERB
bptjm-23	28	5	the	the	DET
bptjm-23	28	6	patient	patient	NOUN
bptjm-23	28	7	’s	’s	PART
bptjm-23	28	8	symptoms	symptom	NOUN
bptjm-23	28	9	,	,	PUNCT
bptjm-23	28	10	and	and	CCONJ
bptjm-23	28	11	do	do	AUX
bptjm-23	28	12	not	not	PART
bptjm-23	28	13	stop	stop	VERB
bptjm-23	28	14	or	or	CCONJ
bptjm-23	28	15	reverse	reverse	VERB
bptjm-23	28	16	damage	damage	NOUN
bptjm-23	28	17	to	to	ADP
bptjm-23	28	18	the	the	DET
bptjm-23	28	19	lungs2	lungs2	NOUN
bptjm-23	28	20	.	.	PUNCT
bptjm-23	29	1	bronchodilators	bronchodilator	NOUN
bptjm-23	29	2	,	,	PUNCT
bptjm-23	29	3	such	such	ADJ
bptjm-23	29	4	as	as	ADP
bptjm-23	29	5	β	β	NOUN
bptjm-23	29	6	-	-	NOUN
bptjm-23	29	7	agonists	agonist	NOUN
bptjm-23	29	8	and	and	CCONJ
bptjm-23	29	9	muscarinic	muscarinic	ADJ
bptjm-23	29	10	antagonists	antagonist	NOUN
bptjm-23	29	11	work	work	VERB
bptjm-23	29	12	to	to	PART
bptjm-23	29	13	relax	relax	VERB
bptjm-23	29	14	the	the	DET
bptjm-23	29	15	muscles	muscle	NOUN
bptjm-23	29	16	in	in	ADP
bptjm-23	29	17	the	the	DET
bptjm-23	29	18	lungs	lung	NOUN
bptjm-23	29	19	to	to	PART
bptjm-23	29	20	alleviate	alleviate	VERB
bptjm-23	29	21	coughing	cough	VERB
bptjm-23	29	22	and	and	CCONJ
bptjm-23	29	23	make	make	VERB
bptjm-23	29	24	breathing	breathing	NOUN
bptjm-23	29	25	easier	easy	ADJ
bptjm-23	29	26	,	,	PUNCT
bptjm-23	29	27	whereas	whereas	SCONJ
bptjm-23	29	28	inhaled	inhale	VERB
bptjm-23	29	29	steroids	steroid	NOUN
bptjm-23	29	30	reduce	reduce	VERB
bptjm-23	29	31	airway	airway	NOUN
bptjm-23	29	32	in	in	ADP
bptjm-23	29	33	�	�	PROPN
bptjm-23	29	34	ammation	ammation	NOUN
bptjm-23	29	35	and	and	CCONJ
bptjm-23	29	36	help	help	VERB
bptjm-23	29	37	prevent	prevent	VERB
bptjm-23	29	38	exacerbations	exacerbation	NOUN
bptjm-23	29	39	.	.	PUNCT
bptjm-23	30	1	working	work	VERB
bptjm-23	30	2	towards	towards	ADP
bptjm-23	30	3	a	a	DET
bptjm-23	30	4	treatment	treatment	NOUN
bptjm-23	30	5	for	for	ADP
bptjm-23	30	6	copd	copd	NOUN
bptjm-23	30	7	that	that	PRON
bptjm-23	30	8	could	could	AUX
bptjm-23	30	9	prevent	prevent	VERB
bptjm-23	30	10	or	or	CCONJ
bptjm-23	30	11	reverse	reverse	VERB
bptjm-23	30	12	lung	lung	NOUN
bptjm-23	30	13	damage	damage	NOUN
bptjm-23	30	14	,	,	PUNCT
bptjm-23	30	15	would	would	AUX
bptjm-23	30	16	impact	impact	VERB
bptjm-23	30	17	the	the	DET
bptjm-23	30	18	lives	life	NOUN
bptjm-23	30	19	of	of	ADP
bptjm-23	30	20	millions	million	NOUN
bptjm-23	30	21	.	.	PUNCT
bptjm-23	31	1	gene	gene	NOUN
bptjm-23	31	2	therapy	therapy	NOUN
bptjm-23	31	3	is	be	AUX
bptjm-23	31	4	an	an	DET
bptjm-23	31	5	attractive	attractive	ADJ
bptjm-23	31	6	alternative	alternative	NOUN
bptjm-23	31	7	to	to	ADP
bptjm-23	31	8	current	current	ADJ
bptjm-23	31	9	treatments	treatment	NOUN
bptjm-23	31	10	,	,	PUNCT
bptjm-23	31	11	it	it	PRON
bptjm-23	31	12	is	be	AUX
bptjm-23	31	13	able	able	ADJ
bptjm-23	31	14	to	to	PART
bptjm-23	31	15	deliver	deliver	VERB
bptjm-23	31	16	medications	medication	NOUN
bptjm-23	31	17	and	and	CCONJ
bptjm-23	31	18	therapeutics	therapeutic	NOUN
bptjm-23	31	19	to	to	ADP
bptjm-23	31	20	speci	speci	PROPN
bptjm-23	31	21	�	�	PROPN
bptjm-23	31	22	c	c	PROPN
bptjm-23	31	23	target	target	NOUN
bptjm-23	31	24	sites	site	NOUN
bptjm-23	31	25	within	within	ADP
bptjm-23	31	26	the	the	DET
bptjm-23	31	27	lungs	lung	NOUN
bptjm-23	31	28	.	.	PUNCT
bptjm-23	32	1	however	however	ADV
bptjm-23	32	2	,	,	PUNCT
bptjm-23	32	3	it	it	PRON
bptjm-23	32	4	's	be	AUX
bptjm-23	32	5	important	important	ADJ
bptjm-23	32	6	to	to	PART
bptjm-23	32	7	note	note	VERB
bptjm-23	32	8	that	that	SCONJ
bptjm-23	32	9	there	there	PRON
bptjm-23	32	10	are	be	VERB
bptjm-23	32	11	limitations	limitation	NOUN
bptjm-23	32	12	due	due	ADJ
bptjm-23	32	13	to	to	ADP
bptjm-23	32	14	various	various	ADJ
bptjm-23	32	15	biological	biological	ADJ
bptjm-23	32	16	barriers	barrier	NOUN
bptjm-23	32	17	.	.	PUNCT
bptjm-23	33	1	these	these	DET
bptjm-23	33	2	limitations	limitation	NOUN
bptjm-23	33	3	can	can	AUX
bptjm-23	33	4	include	include	VERB
bptjm-23	33	5	;	;	PUNCT
bptjm-23	33	6	o	o	X
bptjm-23	33	7	�	�	NOUN
bptjm-23	33	8	-target	-target	NOUN
bptjm-23	33	9	vector	vector	NOUN
bptjm-23	33	10	e	e	NOUN
bptjm-23	33	11	�	�	NOUN
bptjm-23	33	12	ects	ect	NOUN
bptjm-23	33	13	,	,	PUNCT
bptjm-23	33	14	genetic	genetic	ADJ
bptjm-23	33	15	material	material	NOUN
bptjm-23	33	16	,	,	PUNCT
bptjm-23	33	17	and	and	CCONJ
bptjm-23	33	18	delivery	delivery	NOUN
bptjm-23	33	19	e	e	PROPN
bptjm-23	33	20	�	�	PROPN
bptjm-23	33	21	cacy1	cacy1	X
bptjm-23	33	22	.	.	PUNCT
bptjm-23	34	1	due	due	ADP
bptjm-23	34	2	to	to	ADP
bptjm-23	34	3	the	the	DET
bptjm-23	34	4	variety	variety	NOUN
bptjm-23	34	5	of	of	ADP
bptjm-23	34	6	infections	infection	NOUN
bptjm-23	34	7	causing	cause	VERB
bptjm-23	34	8	diseases	disease	NOUN
bptjm-23	34	9	in	in	ADP
bptjm-23	34	10	the	the	DET
bptjm-23	34	11	respiratory	respiratory	ADJ
bptjm-23	34	12	system	system	NOUN
bptjm-23	34	13	,	,	PUNCT
bptjm-23	34	14	there	there	PRON
bptjm-23	34	15	are	be	VERB
bptjm-23	34	16	only	only	ADV
bptjm-23	34	17	17	17	NUM
bptjm-23	34	18	fda	fda	PROPN
bptjm-23	34	19	approved	approve	VERB
bptjm-23	34	20	treatments	treatment	NOUN
bptjm-23	34	21	available	available	ADJ
bptjm-23	34	22	for	for	ADP
bptjm-23	34	23	patients	patient	NOUN
bptjm-23	34	24	,	,	PUNCT
bptjm-23	34	25	none	none	NOUN
bptjm-23	34	26	of	of	ADP
bptjm-23	34	27	which	which	PRON
bptjm-23	34	28	treat	treat	VERB
bptjm-23	34	29	lung	lung	PROPN
bptjm-23	34	30	diseases1	diseases1	PROPN
bptjm-23	34	31	.	.	PUNCT
bptjm-23	35	1	abecma	abecma	PROPN
bptjm-23	35	2	is	be	AUX
bptjm-23	35	3	an	an	DET
bptjm-23	35	4	example	example	NOUN
bptjm-23	35	5	of	of	ADP
bptjm-23	35	6	an	an	DET
bptjm-23	35	7	approved	approve	VERB
bptjm-23	35	8	gene	gene	NOUN
bptjm-23	35	9	berkeley	berkeley	PROPN
bptjm-23	35	10	pharma	pharma	PROPN
bptjm-23	35	11	tech	tech	NOUN
bptjm-23	35	12	journal	journal	NOUN
bptjm-23	35	13	of	of	ADP
bptjm-23	35	14	medicine	medicine	NOUN
bptjm-23	35	15	|	|	ADV
bptjm-23	35	16	60	60	NUM
bptjm-23	35	17	therapy	therapy	NOUN
bptjm-23	35	18	that	that	PRON
bptjm-23	35	19	treats	treat	VERB
bptjm-23	35	20	multiple	multiple	ADJ
bptjm-23	35	21	myeloma	myeloma	NOUN
bptjm-23	35	22	,	,	PUNCT
bptjm-23	35	23	a	a	DET
bptjm-23	35	24	disease	disease	NOUN
bptjm-23	35	25	where	where	SCONJ
bptjm-23	35	26	the	the	DET
bptjm-23	35	27	body	body	NOUN
bptjm-23	35	28	’s	’s	PART
bptjm-23	35	29	white	white	ADJ
bptjm-23	35	30	blood	blood	NOUN
bptjm-23	35	31	cells	cell	NOUN
bptjm-23	35	32	proliferate	proliferate	VERB
bptjm-23	35	33	and	and	CCONJ
bptjm-23	35	34	cause	cause	VERB
bptjm-23	35	35	harmful	harmful	ADJ
bptjm-23	35	36	build	build	NOUN
bptjm-23	35	37	ups	up	NOUN
bptjm-23	35	38	throughout	throughout	ADP
bptjm-23	35	39	the	the	DET
bptjm-23	35	40	body	body	NOUN
bptjm-23	35	41	.	.	PUNCT
bptjm-23	36	1	this	this	DET
bptjm-23	36	2	speci	speci	PROPN
bptjm-23	36	3	�	�	PROPN
bptjm-23	36	4	c	c	PROPN
bptjm-23	36	5	gene	gene	NOUN
bptjm-23	36	6	therapy	therapy	NOUN
bptjm-23	36	7	modi	modi	PROPN
bptjm-23	36	8	�	�	PROPN
bptjm-23	36	9	es	es	VERB
bptjm-23	36	10	the	the	DET
bptjm-23	36	11	patient	patient	NOUN
bptjm-23	36	12	’s	’s	PART
bptjm-23	36	13	t	t	PROPN
bptjm-23	36	14	-	-	PUNCT
bptjm-23	36	15	cells	cell	NOUN
bptjm-23	36	16	to	to	PART
bptjm-23	36	17	attack	attack	VERB
bptjm-23	36	18	the	the	DET
bptjm-23	36	19	cancerous	cancerous	ADJ
bptjm-23	36	20	white	white	ADJ
bptjm-23	36	21	blood	blood	NOUN
bptjm-23	36	22	cells4	cells4	NOUN
bptjm-23	36	23	.	.	PUNCT
bptjm-23	37	1	another	another	DET
bptjm-23	37	2	example	example	NOUN
bptjm-23	37	3	includes	include	VERB
bptjm-23	37	4	luxturna	luxturna	NOUN
bptjm-23	37	5	,	,	PUNCT
bptjm-23	37	6	a	a	DET
bptjm-23	37	7	viral	viral	ADJ
bptjm-23	37	8	vector	vector	NOUN
bptjm-23	37	9	gene	gene	NOUN
bptjm-23	37	10	therapy	therapy	NOUN
bptjm-23	37	11	form	form	NOUN
bptjm-23	37	12	that	that	PRON
bptjm-23	37	13	treats	treat	VERB
bptjm-23	37	14	congenital	congenital	ADJ
bptjm-23	37	15	blindness	blindness	NOUN
bptjm-23	37	16	.	.	PUNCT
bptjm-23	38	1	most	most	ADJ
bptjm-23	38	2	patients	patient	NOUN
bptjm-23	38	3	with	with	ADP
bptjm-23	38	4	congenital	congenital	ADJ
bptjm-23	38	5	blindness	blindness	NOUN
bptjm-23	38	6	contain	contain	VERB
bptjm-23	38	7	a	a	DET
bptjm-23	38	8	mutation	mutation	NOUN
bptjm-23	38	9	in	in	ADP
bptjm-23	38	10	the	the	DET
bptjm-23	38	11	rpe65	rpe65	NOUN
bptjm-23	38	12	gene	gene	NOUN
bptjm-23	38	13	,	,	PUNCT
bptjm-23	38	14	which	which	PRON
bptjm-23	38	15	produces	produce	VERB
bptjm-23	38	16	the	the	DET
bptjm-23	38	17	chromophore	chromophore	NOUN
bptjm-23	38	18	11	11	NUM
bptjm-23	38	19	-	-	PUNCT
bptjm-23	38	20	cis	cis	NOUN
bptjm-23	38	21	retinal	retinal	ADJ
bptjm-23	38	22	protein	protein	NOUN
bptjm-23	38	23	that	that	PRON
bptjm-23	38	24	is	be	AUX
bptjm-23	38	25	vital	vital	ADJ
bptjm-23	38	26	for	for	ADP
bptjm-23	38	27	eye	eye	NOUN
bptjm-23	38	28	function	function	NOUN
bptjm-23	38	29	.	.	PUNCT
bptjm-23	39	1	luxturna	luxturna	NOUN
bptjm-23	39	2	works	work	VERB
bptjm-23	39	3	by	by	ADP
bptjm-23	39	4	delivering	deliver	VERB
bptjm-23	39	5	functional	functional	ADJ
bptjm-23	39	6	copies	copy	NOUN
bptjm-23	39	7	of	of	ADP
bptjm-23	39	8	the	the	DET
bptjm-23	39	9	rpe65	rpe65	NOUN
bptjm-23	39	10	gene	gene	NOUN
bptjm-23	39	11	to	to	ADP
bptjm-23	39	12	the	the	DET
bptjm-23	39	13	retinal	retinal	ADJ
bptjm-23	39	14	epithelial	epithelial	ADJ
bptjm-23	39	15	cells5	cells5	NOUN
bptjm-23	39	16	.	.	PUNCT
bptjm-23	40	1	cystic	cystic	ADJ
bptjm-23	40	2	fibrosis	fibrosis	NOUN
bptjm-23	40	3	(	(	PUNCT
bptjm-23	40	4	cf	cf	NOUN
bptjm-23	40	5	)	)	PUNCT
bptjm-23	40	6	is	be	AUX
bptjm-23	40	7	a	a	DET
bptjm-23	40	8	common	common	ADJ
bptjm-23	40	9	candidate	candidate	NOUN
bptjm-23	40	10	for	for	ADP
bptjm-23	40	11	gene	gene	NOUN
bptjm-23	40	12	therapy	therapy	NOUN
bptjm-23	40	13	research	research	NOUN
bptjm-23	40	14	and	and	CCONJ
bptjm-23	40	15	can	can	AUX
bptjm-23	40	16	o	o	PART
bptjm-23	40	17	�	�	VERB
bptjm-23	40	18	er	er	INTJ
bptjm-23	40	19	some	some	DET
bptjm-23	40	20	insight	insight	NOUN
bptjm-23	40	21	in	in	ADP
bptjm-23	40	22	the	the	DET
bptjm-23	40	23	treatment	treatment	NOUN
bptjm-23	40	24	of	of	ADP
bptjm-23	40	25	copd	copd	NOUN
bptjm-23	40	26	as	as	ADV
bptjm-23	40	27	well	well	ADV
bptjm-23	40	28	.	.	PUNCT
bptjm-23	41	1	due	due	ADP
bptjm-23	41	2	to	to	ADP
bptjm-23	41	3	defective	defective	ADJ
bptjm-23	41	4	sodium	sodium	NOUN
bptjm-23	41	5	/	/	SYM
bptjm-23	41	6	potassium	potassium	NOUN
bptjm-23	41	7	ion	ion	NOUN
bptjm-23	41	8	channels	channel	NOUN
bptjm-23	41	9	in	in	ADP
bptjm-23	41	10	the	the	DET
bptjm-23	41	11	ciliated	ciliated	ADJ
bptjm-23	41	12	cells	cell	NOUN
bptjm-23	41	13	,	,	PUNCT
bptjm-23	41	14	the	the	DET
bptjm-23	41	15	airway	airway	NOUN
bptjm-23	41	16	becomes	becomes	AUX
bptjm-23	41	17	dehydrated	dehydrate	VERB
bptjm-23	41	18	and	and	CCONJ
bptjm-23	41	19	starts	start	VERB
bptjm-23	41	20	secreting	secrete	VERB
bptjm-23	41	21	more	more	ADJ
bptjm-23	41	22	mucus	mucus	NOUN
bptjm-23	41	23	which	which	PRON
bptjm-23	41	24	is	be	AUX
bptjm-23	41	25	a	a	DET
bptjm-23	41	26	breeding	breeding	NOUN
bptjm-23	41	27	ground	ground	NOUN
bptjm-23	41	28	for	for	ADP
bptjm-23	41	29	infection	infection	NOUN
bptjm-23	41	30	-	-	PUNCT
bptjm-23	41	31	causing	cause	VERB
bptjm-23	41	32	bacteria	bacteria	NOUN
bptjm-23	41	33	.	.	PUNCT
bptjm-23	42	1	because	because	SCONJ
bptjm-23	42	2	of	of	ADP
bptjm-23	42	3	the	the	DET
bptjm-23	42	4	fatality	fatality	NOUN
bptjm-23	42	5	of	of	ADP
bptjm-23	42	6	the	the	DET
bptjm-23	42	7	airway	airway	NOUN
bptjm-23	42	8	obstruction	obstruction	NOUN
bptjm-23	42	9	,	,	PUNCT
bptjm-23	42	10	doctors	doctor	NOUN
bptjm-23	42	11	are	be	AUX
bptjm-23	42	12	researching	research	VERB
bptjm-23	42	13	to	to	PART
bptjm-23	42	14	replace	replace	VERB
bptjm-23	42	15	the	the	DET
bptjm-23	42	16	cftr	cftr	NOUN
bptjm-23	42	17	gene	gene	NOUN
bptjm-23	42	18	during	during	ADP
bptjm-23	42	19	the	the	DET
bptjm-23	42	20	neonatal	neonatal	ADJ
bptjm-23	42	21	period	period	NOUN
bptjm-23	42	22	to	to	PART
bptjm-23	42	23	maximize	maximize	VERB
bptjm-23	42	24	the	the	DET
bptjm-23	42	25	success	success	NOUN
bptjm-23	42	26	of	of	ADP
bptjm-23	42	27	the	the	DET
bptjm-23	42	28	therapy	therapy	NOUN
bptjm-23	42	29	and	and	CCONJ
bptjm-23	42	30	the	the	DET
bptjm-23	42	31	patients	patient	NOUN
bptjm-23	42	32	’	’	PART
bptjm-23	42	33	quality	quality	NOUN
bptjm-23	42	34	of	of	ADP
bptjm-23	42	35	life6	life6	NOUN
bptjm-23	42	36	.	.	PUNCT
bptjm-23	43	1	to	to	PART
bptjm-23	43	2	deliver	deliver	VERB
bptjm-23	43	3	the	the	DET
bptjm-23	43	4	cftr	cftr	NOUN
bptjm-23	43	5	gene	gene	NOUN
bptjm-23	43	6	into	into	ADP
bptjm-23	43	7	the	the	DET
bptjm-23	43	8	lung	lung	NOUN
bptjm-23	43	9	,	,	PUNCT
bptjm-23	43	10	scientists	scientist	NOUN
bptjm-23	43	11	have	have	AUX
bptjm-23	43	12	experimented	experiment	VERB
bptjm-23	43	13	with	with	ADP
bptjm-23	43	14	the	the	DET
bptjm-23	43	15	oral	oral	ADJ
bptjm-23	43	16	inhalation	inhalation	NOUN
bptjm-23	43	17	of	of	ADP
bptjm-23	43	18	aerosolized	aerosolize	VERB
bptjm-23	43	19	vectors	vector	NOUN
bptjm-23	43	20	using	use	VERB
bptjm-23	43	21	a	a	DET
bptjm-23	43	22	nebulizer	nebulizer	NOUN
bptjm-23	43	23	rather	rather	ADV
bptjm-23	43	24	than	than	ADP
bptjm-23	43	25	a	a	DET
bptjm-23	43	26	liquid	liquid	ADJ
bptjm-23	43	27	�	�	NOUN
bptjm-23	43	28	lled	lle	VERB
bptjm-23	43	29	nasal	nasal	PROPN
bptjm-23	43	30	tube	tube	NOUN
bptjm-23	43	31	.	.	PUNCT
bptjm-23	44	1	this	this	DET
bptjm-23	44	2	method	method	NOUN
bptjm-23	44	3	of	of	ADP
bptjm-23	44	4	delivery	delivery	NOUN
bptjm-23	44	5	reduces	reduce	VERB
bptjm-23	44	6	the	the	DET
bptjm-23	44	7	risk	risk	NOUN
bptjm-23	44	8	of	of	ADP
bptjm-23	44	9	aspiration	aspiration	NOUN
bptjm-23	44	10	and	and	CCONJ
bptjm-23	44	11	could	could	AUX
bptjm-23	44	12	be	be	AUX
bptjm-23	44	13	useful	useful	ADJ
bptjm-23	44	14	when	when	SCONJ
bptjm-23	44	15	treating	treat	VERB
bptjm-23	44	16	other	other	ADJ
bptjm-23	44	17	lung	lung	NOUN
bptjm-23	44	18	diseases	disease	NOUN
bptjm-23	44	19	,	,	PUNCT
bptjm-23	44	20	including	include	VERB
bptjm-23	44	21	copd6	copd6	PROPN
bptjm-23	44	22	.	.	PUNCT
bptjm-23	45	1	modulator	modulator	NOUN
bptjm-23	45	2	therapies	therapy	NOUN
bptjm-23	45	3	are	be	AUX
bptjm-23	45	4	also	also	ADV
bptjm-23	45	5	burgeoning	burgeon	VERB
bptjm-23	45	6	methods	method	NOUN
bptjm-23	45	7	to	to	PART
bptjm-23	45	8	treat	treat	VERB
bptjm-23	45	9	cf	cf	NOUN
bptjm-23	45	10	,	,	PUNCT
bptjm-23	45	11	and	and	CCONJ
bptjm-23	45	12	each	each	DET
bptjm-23	45	13	therapy	therapy	NOUN
bptjm-23	45	14	targets	target	VERB
bptjm-23	45	15	a	a	DET
bptjm-23	45	16	speci	speci	ADJ
bptjm-23	45	17	�	�	PROPN
bptjm-23	45	18	c	c	NOUN
bptjm-23	45	19	mutation	mutation	NOUN
bptjm-23	45	20	in	in	ADP
bptjm-23	45	21	the	the	DET
bptjm-23	45	22	cftr	cftr	NOUN
bptjm-23	45	23	gene	gene	NOUN
bptjm-23	45	24	.	.	PUNCT
bptjm-23	46	1	the	the	DET
bptjm-23	46	2	success	success	NOUN
bptjm-23	46	3	of	of	ADP
bptjm-23	46	4	the	the	DET
bptjm-23	46	5	modulator	modulator	NOUN
bptjm-23	46	6	therapy	therapy	NOUN
bptjm-23	46	7	was	be	AUX
bptjm-23	46	8	shown	show	VERB
bptjm-23	46	9	in	in	ADP
bptjm-23	46	10	a	a	DET
bptjm-23	46	11	research	research	NOUN
bptjm-23	46	12	study	study	NOUN
bptjm-23	46	13	when	when	SCONJ
bptjm-23	46	14	55	55	NUM
bptjm-23	46	15	%	%	NOUN
bptjm-23	46	16	of	of	ADP
bptjm-23	46	17	the	the	DET
bptjm-23	46	18	subjects	subject	NOUN
bptjm-23	46	19	experienced	experience	VERB
bptjm-23	46	20	signi	signi	PROPN
bptjm-23	46	21	�	�	NOUN
bptjm-23	46	22	cant	cant	NOUN
bptjm-23	46	23	decrease	decrease	NOUN
bptjm-23	46	24	in	in	ADP
bptjm-23	46	25	p.aeruginosa7	p.aeruginosa7	PROPN
bptjm-23	46	26	.	.	PUNCT
bptjm-23	47	1	genes	gene	NOUN
bptjm-23	47	2	that	that	PRON
bptjm-23	47	3	contribute	contribute	VERB
bptjm-23	47	4	to	to	PART
bptjm-23	47	5	copd	copd	NOUN
bptjm-23	47	6	such	such	ADJ
bptjm-23	47	7	as	as	ADP
bptjm-23	47	8	serpina1	serpina1	PROPN
bptjm-23	47	9	that	that	PRON
bptjm-23	47	10	causes	cause	VERB
bptjm-23	47	11	an	an	DET
bptjm-23	47	12	α-1	α-1	NOUN
bptjm-23	47	13	antitrypsin	antitrypsin	NOUN
bptjm-23	47	14	de	de	NOUN
bptjm-23	47	15	�	�	NOUN
bptjm-23	47	16	ciency	ciency	NOUN
bptjm-23	47	17	would	would	AUX
bptjm-23	47	18	be	be	AUX
bptjm-23	47	19	a	a	DET
bptjm-23	47	20	good	good	ADJ
bptjm-23	47	21	candidate	candidate	NOUN
bptjm-23	47	22	gene	gene	NOUN
bptjm-23	47	23	for	for	ADP
bptjm-23	47	24	potential	potential	ADJ
bptjm-23	47	25	modulator	modulator	NOUN
bptjm-23	47	26	therapies	therapy	NOUN
bptjm-23	47	27	with	with	ADP
bptjm-23	47	28	certain	certain	ADJ
bptjm-23	47	29	mutations	mutation	NOUN
bptjm-23	47	30	in	in	ADP
bptjm-23	47	31	the	the	DET
bptjm-23	47	32	gene8	gene8	NOUN
bptjm-23	47	33	.	.	PUNCT
bptjm-23	48	1	recent	recent	ADJ
bptjm-23	48	2	genetic	genetic	ADJ
bptjm-23	48	3	,	,	PUNCT
bptjm-23	48	4	biochemical	biochemical	ADJ
bptjm-23	48	5	and	and	CCONJ
bptjm-23	48	6	histological	histological	ADJ
bptjm-23	48	7	evidence	evidence	NOUN
bptjm-23	48	8	also	also	ADV
bptjm-23	48	9	suggests	suggest	VERB
bptjm-23	48	10	altered	alter	VERB
bptjm-23	48	11	transforming	transform	VERB
bptjm-23	48	12	growth	growth	NOUN
bptjm-23	48	13	factor	factor	NOUN
bptjm-23	48	14	beta	beta	NOUN
bptjm-23	48	15	(	(	PUNCT
bptjm-23	48	16	tgf	tgf	PROPN
bptjm-23	48	17	-	-	PUNCT
bptjm-23	48	18	β	β	NOUN
bptjm-23	48	19	)	)	PUNCT
bptjm-23	48	20	signaling	signal	VERB
bptjm-23	48	21	is	be	AUX
bptjm-23	48	22	associated	associate	VERB
bptjm-23	48	23	with	with	ADP
bptjm-23	48	24	copd	copd	PROPN
bptjm-23	48	25	development	development	NOUN
bptjm-23	48	26	and	and	CCONJ
bptjm-23	48	27	progression	progression	NOUN
bptjm-23	48	28	.	.	PUNCT
bptjm-23	49	1	tgf	tgf	PROPN
bptjm-23	49	2	-	-	PUNCT
bptjm-23	49	3	β	β	PROPN
bptjm-23	49	4	regulates	regulate	VERB
bptjm-23	49	5	the	the	DET
bptjm-23	49	6	respiratory	respiratory	ADJ
bptjm-23	49	7	system	system	NOUN
bptjm-23	49	8	and	and	CCONJ
bptjm-23	49	9	can	can	AUX
bptjm-23	49	10	lead	lead	VERB
bptjm-23	49	11	to	to	ADP
bptjm-23	49	12	diseases	disease	NOUN
bptjm-23	49	13	if	if	SCONJ
bptjm-23	49	14	it	it	PRON
bptjm-23	49	15	is	be	AUX
bptjm-23	49	16	mutated	mutate	VERB
bptjm-23	49	17	.	.	PUNCT
bptjm-23	50	1	subduing	subdue	VERB
bptjm-23	50	2	altered	alter	VERB
bptjm-23	50	3	tgf	tgf	PROPN
bptjm-23	50	4	-	-	PUNCT
bptjm-23	50	5	β	β	PROPN
bptjm-23	50	6	signaling	signal	VERB
bptjm-23	50	7	in	in	ADP
bptjm-23	50	8	the	the	DET
bptjm-23	50	9	airways	airway	NOUN
bptjm-23	50	10	and	and	CCONJ
bptjm-23	50	11	alveolar	alveolar	ADJ
bptjm-23	50	12	sacs	sac	NOUN
bptjm-23	50	13	via	via	ADP
bptjm-23	50	14	gene	gene	NOUN
bptjm-23	50	15	silencing	silence	VERB
bptjm-23	50	16	technologies	technology	NOUN
bptjm-23	50	17	may	may	AUX
bptjm-23	50	18	provide	provide	VERB
bptjm-23	50	19	similar	similar	ADJ
bptjm-23	50	20	berkeley	berkeley	PROPN
bptjm-23	50	21	pharma	pharma	PROPN
bptjm-23	50	22	tech	tech	NOUN
bptjm-23	50	23	journal	journal	NOUN
bptjm-23	50	24	of	of	ADP
bptjm-23	50	25	medicine	medicine	NOUN
bptjm-23	50	26	|	|	ADV
bptjm-23	50	27	61	61	NUM
bptjm-23	50	28	therapeutic	therapeutic	ADJ
bptjm-23	50	29	outcomes	outcome	NOUN
bptjm-23	50	30	to	to	PART
bptjm-23	50	31	modulator	modulator	VERB
bptjm-23	50	32	therapies	therapy	NOUN
bptjm-23	50	33	and	and	CCONJ
bptjm-23	50	34	other	other	ADJ
bptjm-23	50	35	treatment	treatment	NOUN
bptjm-23	50	36	options9	options9	NOUN
bptjm-23	50	37	.	.	PUNCT
bptjm-23	51	1	deliveries	deliverie	VERB
bptjm-23	51	2	the	the	DET
bptjm-23	51	3	development	development	NOUN
bptjm-23	51	4	in	in	ADP
bptjm-23	51	5	gene	gene	NOUN
bptjm-23	51	6	therapy	therapy	NOUN
bptjm-23	51	7	for	for	ADP
bptjm-23	51	8	copd	copd	NOUN
bptjm-23	51	9	hinges	hinge	NOUN
bptjm-23	51	10	on	on	ADP
bptjm-23	51	11	several	several	ADJ
bptjm-23	51	12	factors	factor	NOUN
bptjm-23	51	13	,	,	PUNCT
bptjm-23	51	14	one	one	NUM
bptjm-23	51	15	of	of	ADP
bptjm-23	51	16	the	the	DET
bptjm-23	51	17	most	most	ADV
bptjm-23	51	18	prominent	prominent	ADJ
bptjm-23	51	19	of	of	ADP
bptjm-23	51	20	which	which	PRON
bptjm-23	51	21	is	be	AUX
bptjm-23	51	22	delivery	delivery	NOUN
bptjm-23	51	23	method	method	NOUN
bptjm-23	51	24	to	to	PART
bptjm-23	51	25	ensure	ensure	VERB
bptjm-23	51	26	e	e	NOUN
bptjm-23	51	27	�	�	NOUN
bptjm-23	51	28	cacy	cacy	NOUN
bptjm-23	51	29	and	and	CCONJ
bptjm-23	51	30	precision	precision	NOUN
bptjm-23	51	31	in	in	ADP
bptjm-23	51	32	use	use	NOUN
bptjm-23	51	33	of	of	ADP
bptjm-23	51	34	the	the	DET
bptjm-23	51	35	particular	particular	ADJ
bptjm-23	51	36	therapy	therapy	NOUN
bptjm-23	51	37	.	.	PUNCT
bptjm-23	52	1	delivery	delivery	NOUN
bptjm-23	52	2	methods	method	NOUN
bptjm-23	52	3	must	must	AUX
bptjm-23	52	4	optimize	optimize	VERB
bptjm-23	52	5	performance	performance	NOUN
bptjm-23	52	6	and	and	CCONJ
bptjm-23	52	7	transfection	transfection	NOUN
bptjm-23	52	8	as	as	ADV
bptjm-23	52	9	well	well	ADV
bptjm-23	52	10	as	as	ADP
bptjm-23	52	11	safety	safety	NOUN
bptjm-23	52	12	both	both	PRON
bptjm-23	52	13	for	for	ADP
bptjm-23	52	14	the	the	DET
bptjm-23	52	15	patient	patient	NOUN
bptjm-23	52	16	and	and	CCONJ
bptjm-23	52	17	protection	protection	NOUN
bptjm-23	52	18	of	of	ADP
bptjm-23	52	19	genetic	genetic	ADJ
bptjm-23	52	20	material	material	NOUN
bptjm-23	52	21	.	.	PUNCT
bptjm-23	53	1	even	even	ADV
bptjm-23	53	2	in	in	ADP
bptjm-23	53	3	common	common	ADJ
bptjm-23	53	4	inhalable	inhalable	ADJ
bptjm-23	53	5	drug	drug	NOUN
bptjm-23	53	6	delivery	delivery	NOUN
bptjm-23	53	7	,	,	PUNCT
bptjm-23	53	8	limitations	limitation	NOUN
bptjm-23	53	9	are	be	AUX
bptjm-23	53	10	present	present	ADJ
bptjm-23	53	11	due	due	ADP
bptjm-23	53	12	to	to	ADP
bptjm-23	53	13	the	the	DET
bptjm-23	53	14	complex	complex	ADJ
bptjm-23	53	15	defense	defense	NOUN
bptjm-23	53	16	mechanisms	mechanism	NOUN
bptjm-23	53	17	of	of	ADP
bptjm-23	53	18	the	the	DET
bptjm-23	53	19	respiratory	respiratory	ADJ
bptjm-23	53	20	system	system	NOUN
bptjm-23	53	21	.	.	PUNCT
bptjm-23	54	1	these	these	DET
bptjm-23	54	2	factors	factor	NOUN
bptjm-23	54	3	are	be	AUX
bptjm-23	54	4	limited	limit	VERB
bptjm-23	54	5	in	in	ADP
bptjm-23	54	6	e	e	PROPN
bptjm-23	54	7	�	�	NOUN
bptjm-23	54	8	cacy	cacy	NOUN
bptjm-23	54	9	and	and	CCONJ
bptjm-23	54	10	primarily	primarily	ADV
bptjm-23	54	11	focus	focus	VERB
bptjm-23	54	12	on	on	ADP
bptjm-23	54	13	airway	airway	NOUN
bptjm-23	54	14	obstruction	obstruction	NOUN
bptjm-23	54	15	via	via	ADP
bptjm-23	54	16	anticholinergics	anticholinergic	NOUN
bptjm-23	54	17	and	and	CCONJ
bptjm-23	54	18	dual	dual	ADJ
bptjm-23	54	19	β2	β2	NOUN
bptjm-23	54	20	-	-	PUNCT
bptjm-23	54	21	dopamine	dopamine	NOUN
bptjm-23	54	22	2	2	NUM
bptjm-23	54	23	receptor	receptor	NOUN
bptjm-23	54	24	antagonists10	antagonists10	NOUN
bptjm-23	54	25	.	.	PUNCT
bptjm-23	55	1	techniques	technique	NOUN
bptjm-23	55	2	used	use	VERB
bptjm-23	55	3	for	for	ADP
bptjm-23	55	4	gene	gene	NOUN
bptjm-23	55	5	therapy	therapy	NOUN
bptjm-23	55	6	can	can	AUX
bptjm-23	55	7	be	be	AUX
bptjm-23	55	8	separated	separate	VERB
bptjm-23	55	9	into	into	ADP
bptjm-23	55	10	3	3	NUM
bptjm-23	55	11	major	major	ADJ
bptjm-23	55	12	categories	category	NOUN
bptjm-23	55	13	:	:	PUNCT
bptjm-23	55	14	chemical	chemical	NOUN
bptjm-23	55	15	,	,	PUNCT
bptjm-23	55	16	physical	physical	ADJ
bptjm-23	55	17	,	,	PUNCT
bptjm-23	55	18	and	and	CCONJ
bptjm-23	55	19	viral	viral	ADJ
bptjm-23	55	20	.	.	PUNCT
bptjm-23	56	1	chemical	chemical	NOUN
bptjm-23	56	2	techniques	technique	NOUN
bptjm-23	56	3	entail	entail	VERB
bptjm-23	56	4	the	the	DET
bptjm-23	56	5	non	non	ADJ
bptjm-23	56	6	-	-	ADJ
bptjm-23	56	7	viral	viral	ADJ
bptjm-23	56	8	methods	method	NOUN
bptjm-23	56	9	for	for	ADP
bptjm-23	56	10	creating	create	VERB
bptjm-23	56	11	materials	material	NOUN
bptjm-23	56	12	and	and	CCONJ
bptjm-23	56	13	particles	particle	NOUN
bptjm-23	56	14	used	use	VERB
bptjm-23	56	15	to	to	PART
bptjm-23	56	16	transfect	transfect	VERB
bptjm-23	56	17	or	or	CCONJ
bptjm-23	56	18	insert	insert	VERB
bptjm-23	56	19	genetic	genetic	ADJ
bptjm-23	56	20	material	material	NOUN
bptjm-23	56	21	into	into	ADP
bptjm-23	56	22	the	the	DET
bptjm-23	56	23	target	target	NOUN
bptjm-23	56	24	cells	cell	NOUN
bptjm-23	56	25	.	.	PUNCT
bptjm-23	57	1	this	this	PRON
bptjm-23	57	2	can	can	AUX
bptjm-23	57	3	be	be	AUX
bptjm-23	57	4	achieved	achieve	VERB
bptjm-23	57	5	in	in	ADP
bptjm-23	57	6	several	several	ADJ
bptjm-23	57	7	ways	way	NOUN
bptjm-23	57	8	whether	whether	SCONJ
bptjm-23	57	9	it	it	PRON
bptjm-23	57	10	be	be	VERB
bptjm-23	57	11	to	to	PART
bptjm-23	57	12	weaken	weaken	VERB
bptjm-23	57	13	the	the	DET
bptjm-23	57	14	cell	cell	NOUN
bptjm-23	57	15	function	function	NOUN
bptjm-23	57	16	or	or	CCONJ
bptjm-23	57	17	to	to	PART
bptjm-23	57	18	create	create	VERB
bptjm-23	57	19	new	new	ADJ
bptjm-23	57	20	vectors	vector	NOUN
bptjm-23	57	21	that	that	PRON
bptjm-23	57	22	take	take	VERB
bptjm-23	57	23	advantage	advantage	NOUN
bptjm-23	57	24	of	of	ADP
bptjm-23	57	25	common	common	ADJ
bptjm-23	57	26	cellular	cellular	ADJ
bptjm-23	57	27	functions	function	NOUN
bptjm-23	57	28	and	and	CCONJ
bptjm-23	57	29	mechanisms	mechanism	NOUN
bptjm-23	57	30	,	,	PUNCT
bptjm-23	57	31	such	such	ADJ
bptjm-23	57	32	as	as	ADP
bptjm-23	57	33	liposomes	liposome	NOUN
bptjm-23	57	34	and	and	CCONJ
bptjm-23	57	35	nanoparticles	nanoparticle	NOUN
bptjm-23	57	36	(	(	PUNCT
bptjm-23	57	37	nps	nps	PROPN
bptjm-23	57	38	)	)	PUNCT
bptjm-23	57	39	.	.	PUNCT
bptjm-23	58	1	next	next	ADJ
bptjm-23	58	2	,	,	PUNCT
bptjm-23	58	3	physical	physical	ADJ
bptjm-23	58	4	techniques	technique	NOUN
bptjm-23	58	5	revolve	revolve	NOUN
bptjm-23	58	6	around	around	ADP
bptjm-23	58	7	mechanical	mechanical	ADJ
bptjm-23	58	8	methods	method	NOUN
bptjm-23	58	9	to	to	PART
bptjm-23	58	10	typically	typically	ADV
bptjm-23	58	11	achieve	achieve	VERB
bptjm-23	58	12	new	new	ADJ
bptjm-23	58	13	access	access	NOUN
bptjm-23	58	14	points	point	NOUN
bptjm-23	58	15	or	or	CCONJ
bptjm-23	58	16	alter	alter	VERB
bptjm-23	58	17	the	the	DET
bptjm-23	58	18	function	function	NOUN
bptjm-23	58	19	of	of	ADP
bptjm-23	58	20	the	the	DET
bptjm-23	58	21	cell	cell	NOUN
bptjm-23	58	22	slightly	slightly	ADV
bptjm-23	58	23	without	without	ADP
bptjm-23	58	24	introducing	introduce	VERB
bptjm-23	58	25	a	a	DET
bptjm-23	58	26	chemical	chemical	NOUN
bptjm-23	58	27	alteration	alteration	NOUN
bptjm-23	58	28	or	or	CCONJ
bptjm-23	58	29	manipulation	manipulation	NOUN
bptjm-23	58	30	to	to	ADP
bptjm-23	58	31	the	the	DET
bptjm-23	58	32	equation	equation	NOUN
bptjm-23	58	33	.	.	PUNCT
bptjm-23	59	1	increasing	increase	VERB
bptjm-23	59	2	the	the	DET
bptjm-23	59	3	permeability	permeability	NOUN
bptjm-23	59	4	and	and	CCONJ
bptjm-23	59	5	uptake	uptake	NOUN
bptjm-23	59	6	of	of	ADP
bptjm-23	59	7	genetic	genetic	ADJ
bptjm-23	59	8	material	material	NOUN
bptjm-23	59	9	of	of	ADP
bptjm-23	59	10	the	the	DET
bptjm-23	59	11	cell	cell	NOUN
bptjm-23	59	12	or	or	CCONJ
bptjm-23	59	13	direct	direct	ADJ
bptjm-23	59	14	injection	injection	NOUN
bptjm-23	59	15	is	be	AUX
bptjm-23	59	16	the	the	DET
bptjm-23	59	17	most	most	ADV
bptjm-23	59	18	common	common	ADJ
bptjm-23	59	19	mechanism	mechanism	NOUN
bptjm-23	59	20	in	in	ADP
bptjm-23	59	21	which	which	PRON
bptjm-23	59	22	these	these	DET
bptjm-23	59	23	methods	method	NOUN
bptjm-23	59	24	are	be	AUX
bptjm-23	59	25	able	able	ADJ
bptjm-23	59	26	to	to	PART
bptjm-23	59	27	insert	insert	VERB
bptjm-23	59	28	the	the	DET
bptjm-23	59	29	genetic	genetic	ADJ
bptjm-23	59	30	material	material	NOUN
bptjm-23	59	31	.	.	PUNCT
bptjm-23	60	1	the	the	DET
bptjm-23	60	2	more	more	ADV
bptjm-23	60	3	prominent	prominent	ADJ
bptjm-23	60	4	of	of	ADP
bptjm-23	60	5	these	these	PRON
bptjm-23	60	6	is	be	AUX
bptjm-23	60	7	a	a	DET
bptjm-23	60	8	shock	shock	NOUN
bptjm-23	60	9	treatment	treatment	NOUN
bptjm-23	60	10	to	to	PART
bptjm-23	60	11	open	open	VERB
bptjm-23	60	12	the	the	DET
bptjm-23	60	13	cell	cell	NOUN
bptjm-23	60	14	membrane	membrane	NOUN
bptjm-23	60	15	for	for	ADP
bptjm-23	60	16	a	a	DET
bptjm-23	60	17	brief	brief	ADJ
bptjm-23	60	18	period	period	NOUN
bptjm-23	60	19	of	of	ADP
bptjm-23	60	20	time	time	NOUN
bptjm-23	60	21	known	know	VERB
bptjm-23	60	22	as	as	ADP
bptjm-23	60	23	electroporation	electroporation	NOUN
bptjm-23	60	24	(	(	PUNCT
bptjm-23	60	25	ep	ep	NOUN
bptjm-23	60	26	)	)	PUNCT
bptjm-23	60	27	.	.	PUNCT
bptjm-23	61	1	thirdly	thirdly	ADV
bptjm-23	61	2	,	,	PUNCT
bptjm-23	61	3	viral	viral	ADJ
bptjm-23	61	4	delivery	delivery	NOUN
bptjm-23	61	5	methods	method	NOUN
bptjm-23	61	6	are	be	AUX
bptjm-23	61	7	created	create	VERB
bptjm-23	61	8	by	by	ADP
bptjm-23	61	9	modifying	modify	VERB
bptjm-23	61	10	viral	viral	ADJ
bptjm-23	61	11	genomes	genome	NOUN
bptjm-23	61	12	to	to	PART
bptjm-23	61	13	take	take	VERB
bptjm-23	61	14	advantage	advantage	NOUN
bptjm-23	61	15	of	of	ADP
bptjm-23	61	16	viral	viral	ADJ
bptjm-23	61	17	mechanisms	mechanism	NOUN
bptjm-23	61	18	of	of	ADP
bptjm-23	61	19	inserting	insert	VERB
bptjm-23	61	20	genetic	genetic	ADJ
bptjm-23	61	21	material	material	NOUN
bptjm-23	61	22	.	.	PUNCT
bptjm-23	62	1	the	the	DET
bptjm-23	62	2	most	most	ADV
bptjm-23	62	3	common	common	ADJ
bptjm-23	62	4	vectors	vector	NOUN
bptjm-23	62	5	that	that	PRON
bptjm-23	62	6	have	have	AUX
bptjm-23	62	7	extended	extend	VERB
bptjm-23	62	8	into	into	ADP
bptjm-23	62	9	the	the	DET
bptjm-23	62	10	realm	realm	NOUN
bptjm-23	62	11	of	of	ADP
bptjm-23	62	12	gene	gene	NOUN
bptjm-23	62	13	therapy	therapy	NOUN
bptjm-23	62	14	for	for	ADP
bptjm-23	62	15	pulmonary	pulmonary	ADJ
bptjm-23	62	16	diseases	disease	NOUN
bptjm-23	62	17	are	be	AUX
bptjm-23	62	18	ep	ep	PROPN
bptjm-23	62	19	,	,	PUNCT
bptjm-23	62	20	liposomes	liposome	NOUN
bptjm-23	62	21	,	,	PUNCT
bptjm-23	62	22	viral	viral	ADJ
bptjm-23	62	23	vectors	vector	NOUN
bptjm-23	62	24	,	,	PUNCT
bptjm-23	62	25	and	and	CCONJ
bptjm-23	62	26	nps	nps	PROPN
bptjm-23	62	27	.	.	PUNCT
bptjm-23	63	1	each	each	PRON
bptjm-23	63	2	of	of	ADP
bptjm-23	63	3	the	the	DET
bptjm-23	63	4	aforementioned	aforementioned	ADJ
bptjm-23	63	5	methods	method	NOUN
bptjm-23	63	6	give	give	VERB
bptjm-23	63	7	way	way	NOUN
bptjm-23	63	8	to	to	ADP
bptjm-23	63	9	their	their	PRON
bptjm-23	63	10	own	own	ADJ
bptjm-23	63	11	advantages	advantage	NOUN
bptjm-23	63	12	and	and	CCONJ
bptjm-23	63	13	problems	problem	NOUN
bptjm-23	63	14	;	;	PUNCT
bptjm-23	63	15	seen	see	VERB
bptjm-23	63	16	in	in	ADP
bptjm-23	63	17	figure	figure	NOUN
bptjm-23	63	18	2	2	NUM
bptjm-23	63	19	,	,	PUNCT
bptjm-23	63	20	thus	thus	ADV
bptjm-23	63	21	validating	validate	VERB
bptjm-23	63	22	the	the	DET
bptjm-23	63	23	need	need	NOUN
bptjm-23	63	24	for	for	ADP
bptjm-23	63	25	further	further	ADJ
bptjm-23	63	26	research	research	NOUN
bptjm-23	63	27	on	on	ADP
bptjm-23	63	28	gene	gene	NOUN
bptjm-23	63	29	therapy	therapy	NOUN
bptjm-23	63	30	for	for	ADP
bptjm-23	63	31	symptoms	symptom	NOUN
bptjm-23	63	32	of	of	ADP
bptjm-23	63	33	copd	copd	NOUN
bptjm-23	63	34	.	.	PUNCT
bptjm-23	64	1	[	[	X
bptjm-23	64	2	jg1	jg1	X
bptjm-23	64	3	]	]	X
bptjm-23	64	4	longevity	longevity	NOUN
bptjm-23	64	5	and	and	CCONJ
bptjm-23	64	6	�	�	NOUN
bptjm-23	64	7	nding	nde	VERB
bptjm-23	64	8	the	the	DET
bptjm-23	64	9	ideal	ideal	ADJ
bptjm-23	64	10	carrier	carrier	NOUN
bptjm-23	64	11	to	to	PART
bptjm-23	64	12	inhibit	inhibit	VERB
bptjm-23	64	13	the	the	DET
bptjm-23	64	14	e	e	NOUN
bptjm-23	64	15	�	�	PROPN
bptjm-23	64	16	ects	ect	NOUN
bptjm-23	64	17	of	of	ADP
bptjm-23	64	18	copd	copd	NOUN
bptjm-23	64	19	using	use	VERB
bptjm-23	64	20	these	these	DET
bptjm-23	64	21	treatments	treatment	NOUN
bptjm-23	64	22	is	be	AUX
bptjm-23	64	23	necessary	necessary	ADJ
bptjm-23	64	24	to	to	ADP
bptjm-23	64	25	berkeley	berkeley	PROPN
bptjm-23	64	26	pharma	pharma	PROPN
bptjm-23	64	27	tech	tech	NOUN
bptjm-23	64	28	journal	journal	NOUN
bptjm-23	64	29	of	of	ADP
bptjm-23	64	30	medicine	medicine	NOUN
bptjm-23	64	31	|	|	ADV
bptjm-23	64	32	62	62	NUM
bptjm-23	64	33	counteract	counteract	VERB
bptjm-23	64	34	the	the	DET
bptjm-23	64	35	lifelong	lifelong	ADJ
bptjm-23	64	36	e	e	NOUN
bptjm-23	64	37	�	�	NOUN
bptjm-23	64	38	ects	ect	NOUN
bptjm-23	64	39	traditionally	traditionally	ADV
bptjm-23	64	40	associated	associate	VERB
bptjm-23	64	41	with	with	ADP
bptjm-23	64	42	it	it	PRON
bptjm-23	64	43	and	and	CCONJ
bptjm-23	64	44	other	other	ADJ
bptjm-23	64	45	commonplace	commonplace	ADJ
bptjm-23	64	46	pulmonary	pulmonary	ADJ
bptjm-23	64	47	diseases	disease	NOUN
bptjm-23	64	48	.	.	PUNCT
bptjm-23	65	1	figure	figure	NOUN
bptjm-23	65	2	2	2	NUM
bptjm-23	65	3	:	:	PUNCT
bptjm-23	65	4	modeled	model	VERB
bptjm-23	65	5	from	from	ADP
bptjm-23	65	6	diagram	diagram	NOUN
bptjm-23	65	7	of	of	ADP
bptjm-23	65	8	delivery	delivery	NOUN
bptjm-23	65	9	method	method	NOUN
bptjm-23	65	10	choice	choice	NOUN
bptjm-23	65	11	for	for	ADP
bptjm-23	65	12	gene	gene	NOUN
bptjm-23	65	13	therapy	therapy	NOUN
bptjm-23	65	14	in	in	ADP
bptjm-23	65	15	the	the	DET
bptjm-23	65	16	lungs	lung	NOUN
bptjm-23	66	1	[	[	X
bptjm-23	66	2	1	1	NUM
bptjm-23	66	3	]	]	PUNCT
bptjm-23	66	4	.	.	PUNCT
bptjm-23	67	1	the	the	DET
bptjm-23	67	2	more	more	ADV
bptjm-23	67	3	generally	generally	ADV
bptjm-23	67	4	observed	observe	VERB
bptjm-23	67	5	shortcomings	shortcoming	NOUN
bptjm-23	67	6	and	and	CCONJ
bptjm-23	67	7	advantages	advantage	NOUN
bptjm-23	67	8	of	of	ADP
bptjm-23	67	9	each	each	DET
bptjm-23	67	10	key	key	ADJ
bptjm-23	67	11	delivery	delivery	NOUN
bptjm-23	67	12	method	method	NOUN
bptjm-23	67	13	to	to	PART
bptjm-23	67	14	be	be	AUX
bptjm-23	67	15	discussed	discuss	VERB
bptjm-23	67	16	in	in	ADP
bptjm-23	67	17	detail	detail	NOUN
bptjm-23	67	18	.	.	PUNCT
bptjm-23	68	1	individual	individual	ADJ
bptjm-23	68	2	modifications	modification	NOUN
bptjm-23	68	3	,	,	PUNCT
bptjm-23	68	4	especially	especially	ADV
bptjm-23	68	5	in	in	ADP
bptjm-23	68	6	the	the	DET
bptjm-23	68	7	case	case	NOUN
bptjm-23	68	8	of	of	ADP
bptjm-23	68	9	liposomes	liposome	NOUN
bptjm-23	68	10	and	and	CCONJ
bptjm-23	68	11	nps	nps	PROPN
bptjm-23	68	12	,	,	PUNCT
bptjm-23	68	13	can	can	AUX
bptjm-23	68	14	be	be	AUX
bptjm-23	68	15	made	make	VERB
bptjm-23	68	16	to	to	PART
bptjm-23	68	17	better	better	VERB
bptjm-23	68	18	these	these	PRON
bptjm-23	68	19	such	such	ADJ
bptjm-23	68	20	as	as	ADP
bptjm-23	68	21	particle	particle	NOUN
bptjm-23	68	22	coating	coating	NOUN
bptjm-23	68	23	and	and	CCONJ
bptjm-23	68	24	more	more	ADV
bptjm-23	68	25	effective	effective	ADJ
bptjm-23	68	26	targeting	target	VERB
bptjm-23	68	27	mechanisms	mechanism	NOUN
bptjm-23	68	28	.	.	PUNCT
bptjm-23	69	1	non	non	ADJ
bptjm-23	69	2	-	-	ADJ
bptjm-23	69	3	viral	viral	ADJ
bptjm-23	69	4	methods	method	NOUN
bptjm-23	69	5	liposomes	liposome	NOUN
bptjm-23	69	6	taking	take	VERB
bptjm-23	69	7	advantage	advantage	NOUN
bptjm-23	69	8	of	of	ADP
bptjm-23	69	9	natural	natural	ADJ
bptjm-23	69	10	lipid	lipid	NOUN
bptjm-23	69	11	bilayers	bilayer	NOUN
bptjm-23	69	12	to	to	PART
bptjm-23	69	13	employ	employ	VERB
bptjm-23	69	14	liposomes	liposome	NOUN
bptjm-23	69	15	with	with	ADP
bptjm-23	69	16	genetic	genetic	ADJ
bptjm-23	69	17	material	material	NOUN
bptjm-23	69	18	,	,	PUNCT
bptjm-23	69	19	lipoplexes	lipoplexe	NOUN
bptjm-23	69	20	,	,	PUNCT
bptjm-23	69	21	for	for	ADP
bptjm-23	69	22	delivery	delivery	NOUN
bptjm-23	69	23	cargo	cargo	NOUN
bptjm-23	69	24	to	to	ADP
bptjm-23	69	25	cells	cell	NOUN
bptjm-23	69	26	utilizing	utilize	VERB
bptjm-23	69	27	endogenous	endogenous	ADJ
bptjm-23	69	28	functions	function	NOUN
bptjm-23	69	29	of	of	ADP
bptjm-23	69	30	the	the	DET
bptjm-23	69	31	cell	cell	NOUN
bptjm-23	69	32	membrane	membrane	NOUN
bptjm-23	69	33	is	be	AUX
bptjm-23	69	34	one	one	NUM
bptjm-23	69	35	of	of	ADP
bptjm-23	69	36	the	the	DET
bptjm-23	69	37	primary	primary	ADJ
bptjm-23	69	38	strategies	strategy	NOUN
bptjm-23	69	39	in	in	ADP
bptjm-23	69	40	gene	gene	NOUN
bptjm-23	69	41	therapy	therapy	NOUN
bptjm-23	69	42	for	for	ADP
bptjm-23	69	43	copd	copd	NOUN
bptjm-23	69	44	.	.	PUNCT
bptjm-23	70	1	the	the	DET
bptjm-23	70	2	most	most	ADV
bptjm-23	70	3	glaring	glaring	ADJ
bptjm-23	70	4	functional	functional	ADJ
bptjm-23	70	5	advantage	advantage	NOUN
bptjm-23	70	6	of	of	ADP
bptjm-23	70	7	lipofection	lipofection	NOUN
bptjm-23	70	8	as	as	ADP
bptjm-23	70	9	a	a	DET
bptjm-23	70	10	technique	technique	NOUN
bptjm-23	70	11	is	be	AUX
bptjm-23	70	12	the	the	DET
bptjm-23	70	13	lack	lack	NOUN
bptjm-23	70	14	of	of	ADP
bptjm-23	70	15	immune	immune	ADJ
bptjm-23	70	16	response	response	NOUN
bptjm-23	70	17	and	and	CCONJ
bptjm-23	70	18	cytotoxicity	cytotoxicity	NOUN
bptjm-23	70	19	upon	upon	SCONJ
bptjm-23	70	20	transfection	transfection	NOUN
bptjm-23	70	21	that	that	PRON
bptjm-23	70	22	has	have	AUX
bptjm-23	70	23	been	be	AUX
bptjm-23	70	24	observed11,12	observed11,12	ADJ
bptjm-23	70	25	.	.	PUNCT
bptjm-23	71	1	in	in	ADP
bptjm-23	71	2	addition	addition	NOUN
bptjm-23	71	3	to	to	ADP
bptjm-23	71	4	this	this	DET
bptjm-23	71	5	,	,	PUNCT
bptjm-23	71	6	low	low	ADJ
bptjm-23	71	7	cost	cost	NOUN
bptjm-23	71	8	and	and	CCONJ
bptjm-23	71	9	ease	ease	NOUN
bptjm-23	71	10	of	of	ADP
bptjm-23	71	11	use	use	NOUN
bptjm-23	71	12	make	make	VERB
bptjm-23	71	13	liposome	liposome	NOUN
bptjm-23	71	14	based	base	VERB
bptjm-23	71	15	gene	gene	NOUN
bptjm-23	71	16	therapy	therapy	NOUN
bptjm-23	71	17	a	a	DET
bptjm-23	71	18	preferred	preferred	ADJ
bptjm-23	71	19	treatment	treatment	NOUN
bptjm-23	71	20	.	.	PUNCT
bptjm-23	72	1	morphology	morphology	NOUN
bptjm-23	72	2	which	which	PRON
bptjm-23	72	3	mimics	mimic	VERB
bptjm-23	72	4	that	that	PRON
bptjm-23	72	5	of	of	ADP
bptjm-23	72	6	cell	cell	NOUN
bptjm-23	72	7	membranes	membrane	NOUN
bptjm-23	72	8	’	'	PUNCT
bptjm-23	72	9	lipid	lipid	NOUN
bptjm-23	72	10	bilayer	bilayer	NOUN
bptjm-23	72	11	can	can	AUX
bptjm-23	72	12	be	be	AUX
bptjm-23	72	13	modi	modi	PROPN
bptjm-23	72	14	�	�	PROPN
bptjm-23	72	15	ed	ed	PROPN
bptjm-23	72	16	with	with	ADP
bptjm-23	72	17	targeting	target	VERB
bptjm-23	72	18	molecules	molecule	NOUN
bptjm-23	72	19	to	to	PART
bptjm-23	72	20	adhere	adhere	VERB
bptjm-23	72	21	to	to	ADP
bptjm-23	72	22	di	di	NOUN
bptjm-23	72	23	�	�	PROPN
bptjm-23	72	24	erent	erent	NOUN
bptjm-23	72	25	cells	cell	NOUN
bptjm-23	72	26	with	with	ADP
bptjm-23	72	27	more	more	ADJ
bptjm-23	72	28	precision	precision	NOUN
bptjm-23	72	29	and	and	CCONJ
bptjm-23	72	30	limited	limited	ADJ
bptjm-23	72	31	collateral	collateral	ADJ
bptjm-23	72	32	damage	damage	NOUN
bptjm-23	72	33	.	.	PUNCT
bptjm-23	73	1	the	the	DET
bptjm-23	73	2	accepted	accepted	ADJ
bptjm-23	73	3	but	but	CCONJ
bptjm-23	73	4	not	not	PART
bptjm-23	73	5	completely	completely	ADV
bptjm-23	73	6	understood	understand	VERB
bptjm-23	73	7	mechanism	mechanism	NOUN
bptjm-23	73	8	of	of	ADP
bptjm-23	73	9	action	action	NOUN
bptjm-23	73	10	takes	take	VERB
bptjm-23	73	11	advantage	advantage	NOUN
bptjm-23	73	12	of	of	ADP
bptjm-23	73	13	random	random	ADJ
bptjm-23	73	14	brownian	brownian	ADJ
bptjm-23	73	15	motion	motion	NOUN
bptjm-23	73	16	of	of	ADP
bptjm-23	73	17	the	the	DET
bptjm-23	73	18	liposomes	liposome	NOUN
bptjm-23	73	19	upon	upon	SCONJ
bptjm-23	73	20	entrance	entrance	NOUN
bptjm-23	73	21	into	into	ADP
bptjm-23	73	22	the	the	DET
bptjm-23	73	23	cell	cell	NOUN
bptjm-23	73	24	to	to	ADP
bptjm-23	73	25	e	e	NOUN
bptjm-23	73	26	�	�	NOUN
bptjm-23	73	27	ectively	ectively	ADV
bptjm-23	73	28	disperse	disperse	VERB
bptjm-23	73	29	the	the	DET
bptjm-23	73	30	material13	material13	NOUN
bptjm-23	73	31	.	.	PUNCT
bptjm-23	74	1	in	in	ADP
bptjm-23	74	2	generic	generic	ADJ
bptjm-23	74	3	drug	drug	NOUN
bptjm-23	74	4	delivery	delivery	NOUN
bptjm-23	74	5	this	this	PRON
bptjm-23	74	6	allows	allow	VERB
bptjm-23	74	7	for	for	ADP
bptjm-23	74	8	seamless	seamless	NOUN
bptjm-23	74	9	in	in	ADP
bptjm-23	74	10	�	�	PROPN
bptjm-23	74	11	ltration	ltration	NOUN
bptjm-23	74	12	and	and	CCONJ
bptjm-23	74	13	dosing	dosing	NOUN
bptjm-23	74	14	of	of	ADP
bptjm-23	74	15	the	the	DET
bptjm-23	74	16	cell	cell	NOUN
bptjm-23	74	17	.	.	PUNCT
bptjm-23	75	1	however	however	ADV
bptjm-23	75	2	,	,	PUNCT
bptjm-23	75	3	the	the	DET
bptjm-23	75	4	speci	speci	PROPN
bptjm-23	75	5	�	�	PROPN
bptjm-23	75	6	city	city	NOUN
bptjm-23	75	7	of	of	ADP
bptjm-23	75	8	gene	gene	NOUN
bptjm-23	75	9	delivery	delivery	NOUN
bptjm-23	75	10	berkeley	berkeley	PROPN
bptjm-23	75	11	pharma	pharma	PROPN
bptjm-23	75	12	tech	tech	NOUN
bptjm-23	75	13	journal	journal	NOUN
bptjm-23	75	14	of	of	ADP
bptjm-23	75	15	medicine	medicine	NOUN
bptjm-23	75	16	|	|	ADP
bptjm-23	75	17	63	63	NUM
bptjm-23	75	18	requires	require	VERB
bptjm-23	75	19	nuclear	nuclear	ADJ
bptjm-23	75	20	transport	transport	NOUN
bptjm-23	75	21	of	of	ADP
bptjm-23	75	22	the	the	DET
bptjm-23	75	23	contained	contain	VERB
bptjm-23	75	24	genetic	genetic	ADJ
bptjm-23	75	25	material	material	NOUN
bptjm-23	75	26	;	;	PUNCT
bptjm-23	75	27	these	these	DET
bptjm-23	75	28	shortcomings	shortcoming	NOUN
bptjm-23	75	29	can	can	AUX
bptjm-23	75	30	be	be	AUX
bptjm-23	75	31	observed	observe	VERB
bptjm-23	75	32	through	through	ADP
bptjm-23	75	33	endocytosis	endocytosis	NOUN
bptjm-23	75	34	inhibitors	inhibitor	NOUN
bptjm-23	75	35	and	and	CCONJ
bptjm-23	75	36	endosome	endosome	PROPN
bptjm-23	75	37	trackers	tracker	NOUN
bptjm-23	75	38	to	to	PART
bptjm-23	75	39	visualize	visualize	VERB
bptjm-23	75	40	delivery	delivery	NOUN
bptjm-23	75	41	sites14	sites14	NOUN
bptjm-23	75	42	.	.	PUNCT
bptjm-23	76	1	the	the	DET
bptjm-23	76	2	endogenous	endogenous	ADJ
bptjm-23	76	3	nature	nature	NOUN
bptjm-23	76	4	of	of	ADP
bptjm-23	76	5	liposomes	liposome	NOUN
bptjm-23	76	6	is	be	AUX
bptjm-23	76	7	massively	massively	ADV
bptjm-23	76	8	important	important	ADJ
bptjm-23	76	9	for	for	SCONJ
bptjm-23	76	10	pulmonary	pulmonary	ADJ
bptjm-23	76	11	diseases	disease	NOUN
bptjm-23	76	12	and	and	CCONJ
bptjm-23	76	13	speci	speci	NOUN
bptjm-23	76	14	�	�	PROPN
bptjm-23	76	15	cally	cally	ADV
bptjm-23	76	16	copd	copd	VERB
bptjm-23	76	17	where	where	SCONJ
bptjm-23	76	18	constant	constant	ADJ
bptjm-23	76	19	in	in	ADP
bptjm-23	76	20	�	�	PROPN
bptjm-23	76	21	ammation	ammation	NOUN
bptjm-23	76	22	and	and	CCONJ
bptjm-23	76	23	exacerbations	exacerbation	NOUN
bptjm-23	76	24	take	take	VERB
bptjm-23	76	25	place	place	NOUN
bptjm-23	76	26	regularly	regularly	ADV
bptjm-23	76	27	.	.	PUNCT
bptjm-23	77	1	a	a	DET
bptjm-23	77	2	well	well	ADV
bptjm-23	77	3	observed	observe	VERB
bptjm-23	77	4	phenomena	phenomena	NOUN
bptjm-23	77	5	since	since	SCONJ
bptjm-23	77	6	the	the	DET
bptjm-23	77	7	1970s	1970	NOUN
bptjm-23	77	8	,	,	PUNCT
bptjm-23	77	9	liposomal	liposomal	ADJ
bptjm-23	77	10	immunogenicity	immunogenicity	NOUN
bptjm-23	77	11	,	,	PUNCT
bptjm-23	77	12	can	can	AUX
bptjm-23	77	13	be	be	AUX
bptjm-23	77	14	built	build	VERB
bptjm-23	77	15	upon	upon	SCONJ
bptjm-23	77	16	even	even	ADV
bptjm-23	77	17	further	far	ADV
bptjm-23	77	18	to	to	PART
bptjm-23	77	19	trigger	trigger	VERB
bptjm-23	77	20	minimal	minimal	ADJ
bptjm-23	77	21	immune	immune	ADJ
bptjm-23	77	22	responses	response	NOUN
bptjm-23	77	23	.	.	PUNCT
bptjm-23	78	1	for	for	ADP
bptjm-23	78	2	example	example	NOUN
bptjm-23	78	3	,	,	PUNCT
bptjm-23	78	4	liposomes	liposome	NOUN
bptjm-23	78	5	for	for	ADP
bptjm-23	78	6	drug	drug	NOUN
bptjm-23	78	7	delivery	delivery	NOUN
bptjm-23	78	8	that	that	PRON
bptjm-23	78	9	showed	show	VERB
bptjm-23	78	10	an	an	DET
bptjm-23	78	11	inverse	inverse	NOUN
bptjm-23	78	12	correlation	correlation	NOUN
bptjm-23	78	13	with	with	ADP
bptjm-23	78	14	immunoglobulin	immunoglobulin	NOUN
bptjm-23	78	15	(	(	PUNCT
bptjm-23	78	16	igm	igm	PROPN
bptjm-23	78	17	)	)	PUNCT
bptjm-23	78	18	in	in	ADP
bptjm-23	78	19	the	the	DET
bptjm-23	78	20	brain	brain	NOUN
bptjm-23	78	21	were	be	AUX
bptjm-23	78	22	modi	modi	PROPN
bptjm-23	78	23	�	�	PROPN
bptjm-23	78	24	ed	ed	PROPN
bptjm-23	78	25	to	to	PART
bptjm-23	78	26	enhance	enhance	VERB
bptjm-23	78	27	absorption	absorption	NOUN
bptjm-23	78	28	of	of	ADP
bptjm-23	78	29	igm	igm	PROPN
bptjm-23	78	30	and	and	CCONJ
bptjm-23	78	31	thus	thus	ADV
bptjm-23	78	32	the	the	DET
bptjm-23	78	33	immune	immune	ADJ
bptjm-23	78	34	response	response	NOUN
bptjm-23	78	35	and	and	CCONJ
bptjm-23	78	36	overall	overall	ADJ
bptjm-23	78	37	e	e	NOUN
bptjm-23	78	38	�	�	NOUN
bptjm-23	78	39	ectiveness	ectiveness	NOUN
bptjm-23	78	40	of	of	ADP
bptjm-23	78	41	the	the	DET
bptjm-23	78	42	treatment	treatment	NOUN
bptjm-23	78	43	was	be	AUX
bptjm-23	78	44	improved15	improved15	ADJ
bptjm-23	78	45	.	.	PUNCT
bptjm-23	79	1	relative	relative	ADJ
bptjm-23	79	2	to	to	ADP
bptjm-23	79	3	the	the	DET
bptjm-23	79	4	lungs	lung	NOUN
bptjm-23	79	5	,	,	PUNCT
bptjm-23	79	6	clinical	clinical	ADJ
bptjm-23	79	7	trials	trial	NOUN
bptjm-23	79	8	have	have	AUX
bptjm-23	79	9	utilized	utilize	VERB
bptjm-23	79	10	lipoplexes	lipoplexe	NOUN
bptjm-23	79	11	in	in	ADP
bptjm-23	79	12	tandem	tandem	NOUN
bptjm-23	79	13	with	with	ADP
bptjm-23	79	14	a	a	DET
bptjm-23	79	15	plasmid	plasmid	NOUN
bptjm-23	79	16	carrying	carry	VERB
bptjm-23	79	17	human	human	ADJ
bptjm-23	79	18	cftr	cftr	NOUN
bptjm-23	79	19	in	in	ADP
bptjm-23	79	20	inhalable	inhalable	ADJ
bptjm-23	79	21	doses	dose	NOUN
bptjm-23	79	22	to	to	PART
bptjm-23	79	23	limit	limit	VERB
bptjm-23	79	24	mucus	mucus	NOUN
bptjm-23	79	25	problems	problem	NOUN
bptjm-23	79	26	in	in	ADP
bptjm-23	79	27	patients	patient	NOUN
bptjm-23	79	28	with	with	ADP
bptjm-23	79	29	cf	cf	NOUN
bptjm-23	79	30	,	,	PUNCT
bptjm-23	79	31	a	a	DET
bptjm-23	79	32	common	common	ADJ
bptjm-23	79	33	comorbidity	comorbidity	NOUN
bptjm-23	79	34	of	of	ADP
bptjm-23	79	35	copd16	copd16	NOUN
bptjm-23	79	36	.	.	PUNCT
bptjm-23	80	1	the	the	DET
bptjm-23	80	2	bene	bene	PROPN
bptjm-23	80	3	�	�	PROPN
bptjm-23	80	4	ts	ts	ADP
bptjm-23	80	5	of	of	ADP
bptjm-23	80	6	these	these	DET
bptjm-23	80	7	native	native	ADJ
bptjm-23	80	8	characteristics	characteristic	NOUN
bptjm-23	80	9	of	of	ADP
bptjm-23	80	10	liposomes	liposome	NOUN
bptjm-23	80	11	are	be	AUX
bptjm-23	80	12	signi	signi	ADJ
bptjm-23	80	13	�	�	NOUN
bptjm-23	80	14	cant	cant	NOUN
bptjm-23	80	15	but	but	CCONJ
bptjm-23	80	16	can	can	AUX
bptjm-23	80	17	present	present	VERB
bptjm-23	80	18	their	their	PRON
bptjm-23	80	19	own	own	ADJ
bptjm-23	80	20	pitfalls	pitfall	NOUN
bptjm-23	80	21	as	as	ADV
bptjm-23	80	22	well	well	ADV
bptjm-23	80	23	which	which	PRON
bptjm-23	80	24	must	must	AUX
bptjm-23	80	25	be	be	AUX
bptjm-23	80	26	monitored	monitor	VERB
bptjm-23	80	27	.	.	PUNCT
bptjm-23	81	1	natural	natural	ADJ
bptjm-23	81	2	mechanisms	mechanism	NOUN
bptjm-23	81	3	can	can	AUX
bptjm-23	81	4	act	act	VERB
bptjm-23	81	5	as	as	SCONJ
bptjm-23	81	6	impediments	impediment	NOUN
bptjm-23	81	7	to	to	PART
bptjm-23	81	8	treatments	treatment	NOUN
bptjm-23	81	9	such	such	ADJ
bptjm-23	81	10	as	as	ADP
bptjm-23	81	11	the	the	DET
bptjm-23	81	12	bovine	bovine	ADJ
bptjm-23	81	13	pulmonary	pulmonary	ADJ
bptjm-23	81	14	surfactant	surfactant	NOUN
bptjm-23	81	15	alveofact	alveofact	NOUN
bptjm-23	81	16	have	have	AUX
bptjm-23	81	17	been	be	AUX
bptjm-23	81	18	shown	show	VERB
bptjm-23	81	19	to	to	PART
bptjm-23	81	20	weaken	weaken	VERB
bptjm-23	81	21	berkeley	berkeley	PROPN
bptjm-23	81	22	pharma	pharma	PROPN
bptjm-23	81	23	tech	tech	NOUN
bptjm-23	81	24	journal	journal	NOUN
bptjm-23	81	25	of	of	ADP
bptjm-23	81	26	medicine	medicine	NOUN
bptjm-23	82	1	|	|	ADV
bptjm-23	82	2	64	64	NUM
bptjm-23	82	3	figure	figure	NOUN
bptjm-23	82	4	3	3	NUM
bptjm-23	82	5	:	:	PUNCT
bptjm-23	82	6	image	image	NOUN
bptjm-23	82	7	shows	show	VERB
bptjm-23	82	8	the	the	DET
bptjm-23	82	9	mechanism	mechanism	NOUN
bptjm-23	82	10	by	by	ADP
bptjm-23	82	11	which	which	PRON
bptjm-23	82	12	liposomes	liposome	NOUN
bptjm-23	82	13	(	(	PUNCT
bptjm-23	82	14	and	and	CCONJ
bptjm-23	82	15	some	some	DET
bptjm-23	82	16	nps	nps	PROPN
bptjm-23	82	17	)	)	PUNCT
bptjm-23	82	18	can	can	AUX
bptjm-23	82	19	introduce	introduce	VERB
bptjm-23	82	20	genetic	genetic	ADJ
bptjm-23	82	21	information	information	NOUN
bptjm-23	82	22	into	into	ADP
bptjm-23	82	23	a	a	DET
bptjm-23	82	24	cell	cell	NOUN
bptjm-23	82	25	by	by	ADP
bptjm-23	82	26	taking	take	VERB
bptjm-23	82	27	advantage	advantage	NOUN
bptjm-23	82	28	of	of	ADP
bptjm-23	82	29	endocytosis	endocytosis	NOUN
bptjm-23	82	30	,	,	PUNCT
bptjm-23	82	31	a	a	DET
bptjm-23	82	32	natural	natural	ADJ
bptjm-23	82	33	cell	cell	NOUN
bptjm-23	82	34	mechanism	mechanism	NOUN
bptjm-23	82	35	,	,	PUNCT
bptjm-23	82	36	and	and	CCONJ
bptjm-23	82	37	limiting	limit	VERB
bptjm-23	82	38	the	the	DET
bptjm-23	82	39	immune	immune	ADJ
bptjm-23	82	40	response	response	NOUN
bptjm-23	82	41	–	–	PUNCT
bptjm-23	82	42	thanks	thank	NOUN
bptjm-23	82	43	to	to	ADP
bptjm-23	82	44	the	the	DET
bptjm-23	82	45	endogenous	endogenous	ADJ
bptjm-23	82	46	nature	nature	NOUN
bptjm-23	82	47	of	of	ADP
bptjm-23	82	48	the	the	DET
bptjm-23	82	49	liposomal	liposomal	ADJ
bptjm-23	82	50	structure	structure	NOUN
bptjm-23	82	51	and	and	CCONJ
bptjm-23	82	52	makeup	makeup	NOUN
bptjm-23	82	53	.	.	PUNCT
bptjm-23	83	1	several	several	ADJ
bptjm-23	83	2	types	type	NOUN
bptjm-23	83	3	of	of	ADP
bptjm-23	83	4	lipoplexes17	lipoplexes17	ADV
bptjm-23	83	5	.	.	PUNCT
bptjm-23	84	1	overcoming	overcome	VERB
bptjm-23	84	2	these	these	DET
bptjm-23	84	3	innate	innate	ADJ
bptjm-23	84	4	obstacles	obstacle	NOUN
bptjm-23	84	5	while	while	SCONJ
bptjm-23	84	6	maintaining	maintain	VERB
bptjm-23	84	7	the	the	DET
bptjm-23	84	8	key	key	ADJ
bptjm-23	84	9	bene	bene	NOUN
bptjm-23	84	10	�	�	PROPN
bptjm-23	84	11	ts	ts	ADP
bptjm-23	84	12	of	of	ADP
bptjm-23	84	13	lipoplex	lipoplex	PROPN
bptjm-23	84	14	usage	usage	NOUN
bptjm-23	84	15	is	be	AUX
bptjm-23	84	16	of	of	ADP
bptjm-23	84	17	paramount	paramount	ADJ
bptjm-23	84	18	importance	importance	NOUN
bptjm-23	84	19	and	and	CCONJ
bptjm-23	84	20	needs	need	VERB
bptjm-23	84	21	more	more	ADJ
bptjm-23	84	22	research	research	NOUN
bptjm-23	84	23	to	to	PART
bptjm-23	84	24	fully	fully	ADV
bptjm-23	84	25	understand	understand	VERB
bptjm-23	84	26	the	the	DET
bptjm-23	84	27	functionality	functionality	NOUN
bptjm-23	84	28	in	in	ADP
bptjm-23	84	29	di	di	NOUN
bptjm-23	84	30	�	�	PROPN
bptjm-23	84	31	erent	erent	NOUN
bptjm-23	84	32	cell	cell	NOUN
bptjm-23	84	33	types	type	NOUN
bptjm-23	84	34	within	within	ADP
bptjm-23	84	35	the	the	DET
bptjm-23	84	36	pulmonary	pulmonary	ADJ
bptjm-23	84	37	system	system	NOUN
bptjm-23	84	38	.	.	PUNCT
bptjm-23	85	1	speci	speci	PROPN
bptjm-23	85	2	�	�	PROPN
bptjm-23	85	3	c	c	PROPN
bptjm-23	85	4	work	work	NOUN
bptjm-23	85	5	with	with	ADP
bptjm-23	85	6	cells	cell	NOUN
bptjm-23	85	7	and	and	CCONJ
bptjm-23	85	8	the	the	DET
bptjm-23	85	9	mechanisms	mechanism	NOUN
bptjm-23	85	10	of	of	ADP
bptjm-23	85	11	the	the	DET
bptjm-23	85	12	pulmonary	pulmonary	ADJ
bptjm-23	85	13	system	system	NOUN
bptjm-23	85	14	will	will	AUX
bptjm-23	85	15	yield	yield	VERB
bptjm-23	85	16	a	a	DET
bptjm-23	85	17	better	well	ADJ
bptjm-23	85	18	understanding	understanding	NOUN
bptjm-23	85	19	of	of	ADP
bptjm-23	85	20	how	how	SCONJ
bptjm-23	85	21	lipofection	lipofection	NOUN
bptjm-23	85	22	can	can	AUX
bptjm-23	85	23	be	be	AUX
bptjm-23	85	24	used	use	VERB
bptjm-23	85	25	as	as	ADP
bptjm-23	85	26	a	a	DET
bptjm-23	85	27	widespread	widespread	ADJ
bptjm-23	85	28	treatment	treatment	NOUN
bptjm-23	85	29	.	.	PUNCT
bptjm-23	86	1	nanoparticles	nanoparticle	NOUN
bptjm-23	86	2	nps	nps	PROPN
bptjm-23	86	3	(	(	PUNCT
bptjm-23	86	4	nanoparticles	nanoparticle	NOUN
bptjm-23	86	5	)	)	PUNCT
bptjm-23	86	6	are	be	AUX
bptjm-23	86	7	a	a	DET
bptjm-23	86	8	massive	massive	ADJ
bptjm-23	86	9	and	and	CCONJ
bptjm-23	86	10	growing	grow	VERB
bptjm-23	86	11	�	�	NOUN
bptjm-23	86	12	eld	eld	NOUN
bptjm-23	86	13	of	of	ADP
bptjm-23	86	14	research	research	NOUN
bptjm-23	86	15	for	for	ADP
bptjm-23	86	16	a	a	DET
bptjm-23	86	17	number	number	NOUN
bptjm-23	86	18	of	of	ADP
bptjm-23	86	19	possibilities	possibility	NOUN
bptjm-23	86	20	including	include	VERB
bptjm-23	86	21	gene	gene	NOUN
bptjm-23	86	22	therapy	therapy	NOUN
bptjm-23	86	23	for	for	ADP
bptjm-23	86	24	the	the	DET
bptjm-23	86	25	lungs	lung	NOUN
bptjm-23	86	26	.	.	PUNCT
bptjm-23	87	1	nanoparticles	nanoparticle	NOUN
bptjm-23	87	2	for	for	ADP
bptjm-23	87	3	gene	gene	NOUN
bptjm-23	87	4	therapy	therapy	NOUN
bptjm-23	87	5	can	can	AUX
bptjm-23	87	6	be	be	AUX
bptjm-23	87	7	characterized	characterize	VERB
bptjm-23	87	8	by	by	ADP
bptjm-23	87	9	submicron	submicron	NOUN
bptjm-23	87	10	sized	size	VERB
bptjm-23	87	11	particles	particle	NOUN
bptjm-23	87	12	that	that	PRON
bptjm-23	87	13	berkeley	berkeley	PROPN
bptjm-23	87	14	pharma	pharma	PROPN
bptjm-23	87	15	tech	tech	NOUN
bptjm-23	87	16	journal	journal	NOUN
bptjm-23	87	17	of	of	ADP
bptjm-23	87	18	medicine	medicine	NOUN
bptjm-23	87	19	|	|	ADV
bptjm-23	87	20	65	65	NUM
bptjm-23	87	21	optimize	optimize	NOUN
bptjm-23	87	22	surface	surface	NOUN
bptjm-23	87	23	to	to	PART
bptjm-23	87	24	volume	volume	VERB
bptjm-23	87	25	ratios	ratio	NOUN
bptjm-23	87	26	while	while	SCONJ
bptjm-23	87	27	maintaining	maintain	VERB
bptjm-23	87	28	good	good	ADJ
bptjm-23	87	29	performance	performance	NOUN
bptjm-23	87	30	of	of	ADP
bptjm-23	87	31	biocompatibility	biocompatibility	NOUN
bptjm-23	87	32	and	and	CCONJ
bptjm-23	87	33	biodegradation3	biodegradation3	PROPN
bptjm-23	87	34	.	.	PUNCT
bptjm-23	88	1	the	the	DET
bptjm-23	88	2	customizability	customizability	NOUN
bptjm-23	88	3	of	of	ADP
bptjm-23	88	4	nps	nps	PROPN
bptjm-23	88	5	for	for	ADP
bptjm-23	88	6	di	di	PROPN
bptjm-23	88	7	�	�	PROPN
bptjm-23	88	8	erent	erent	NOUN
bptjm-23	88	9	cell	cell	NOUN
bptjm-23	88	10	types	type	NOUN
bptjm-23	88	11	,	,	PUNCT
bptjm-23	88	12	degrees	degree	NOUN
bptjm-23	88	13	of	of	ADP
bptjm-23	88	14	accumulation	accumulation	NOUN
bptjm-23	88	15	,	,	PUNCT
bptjm-23	88	16	and	and	CCONJ
bptjm-23	88	17	degradation	degradation	NOUN
bptjm-23	88	18	o	o	NOUN
bptjm-23	88	19	�	�	NOUN
bptjm-23	88	20	er	er	ADJ
bptjm-23	88	21	several	several	ADJ
bptjm-23	88	22	advantages	advantage	NOUN
bptjm-23	88	23	as	as	ADP
bptjm-23	88	24	carriers	carrier	NOUN
bptjm-23	88	25	for	for	ADP
bptjm-23	88	26	gene	gene	NOUN
bptjm-23	88	27	therapy	therapy	NOUN
bptjm-23	88	28	treatment	treatment	NOUN
bptjm-23	88	29	in	in	ADP
bptjm-23	88	30	the	the	DET
bptjm-23	88	31	pulmonary	pulmonary	ADJ
bptjm-23	88	32	system	system	NOUN
bptjm-23	88	33	.	.	PUNCT
bptjm-23	89	1	taking	take	VERB
bptjm-23	89	2	advantage	advantage	NOUN
bptjm-23	89	3	of	of	ADP
bptjm-23	89	4	endocytosis	endocytosis	NOUN
bptjm-23	89	5	and	and	CCONJ
bptjm-23	89	6	permeability	permeability	NOUN
bptjm-23	89	7	factors	factor	NOUN
bptjm-23	89	8	of	of	ADP
bptjm-23	89	9	cells	cell	NOUN
bptjm-23	89	10	in	in	ADP
bptjm-23	89	11	similar	similar	ADJ
bptjm-23	89	12	manner	manner	NOUN
bptjm-23	89	13	as	as	ADP
bptjm-23	89	14	lipoplex	lipoplex	NOUN
bptjm-23	89	15	-	-	PUNCT
bptjm-23	89	16	based	base	VERB
bptjm-23	89	17	techniques	technique	NOUN
bptjm-23	89	18	,	,	PUNCT
bptjm-23	89	19	nps	nps	PROPN
bptjm-23	89	20	can	can	AUX
bptjm-23	89	21	utilize	utilize	VERB
bptjm-23	89	22	similar	similar	ADJ
bptjm-23	89	23	lipid	lipid	NOUN
bptjm-23	89	24	based	base	VERB
bptjm-23	89	25	qualities	quality	NOUN
bptjm-23	89	26	but	but	CCONJ
bptjm-23	89	27	are	be	AUX
bptjm-23	89	28	ultimately	ultimately	ADV
bptjm-23	89	29	de	de	X
bptjm-23	89	30	�	�	NOUN
bptjm-23	89	31	ned	ne	VERB
bptjm-23	89	32	by	by	ADP
bptjm-23	89	33	size	size	NOUN
bptjm-23	89	34	and	and	CCONJ
bptjm-23	89	35	their	their	PRON
bptjm-23	89	36	diverse	diverse	ADJ
bptjm-23	89	37	makeup	makeup	NOUN
bptjm-23	89	38	which	which	PRON
bptjm-23	89	39	extends	extend	VERB
bptjm-23	89	40	beyond	beyond	ADP
bptjm-23	89	41	liposomes	liposome	NOUN
bptjm-23	89	42	.	.	PUNCT
bptjm-23	90	1	targeting	target	VERB
bptjm-23	90	2	cells	cell	NOUN
bptjm-23	90	3	and	and	CCONJ
bptjm-23	90	4	material	material	NOUN
bptjm-23	90	5	within	within	ADP
bptjm-23	90	6	the	the	DET
bptjm-23	90	7	airways	airways	PROPN
bptjm-23	90	8	limits	limit	VERB
bptjm-23	90	9	the	the	DET
bptjm-23	90	10	abilities	ability	NOUN
bptjm-23	90	11	to	to	PART
bptjm-23	90	12	penetrate	penetrate	VERB
bptjm-23	90	13	into	into	ADP
bptjm-23	90	14	the	the	DET
bptjm-23	90	15	tissue	tissue	NOUN
bptjm-23	90	16	for	for	ADP
bptjm-23	90	17	many	many	ADJ
bptjm-23	90	18	delivery	delivery	NOUN
bptjm-23	90	19	methods	method	NOUN
bptjm-23	90	20	.	.	PUNCT
bptjm-23	91	1	as	as	SCONJ
bptjm-23	91	2	mentioned	mention	VERB
bptjm-23	91	3	,	,	PUNCT
bptjm-23	91	4	liposomes	liposome	NOUN
bptjm-23	91	5	can	can	AUX
bptjm-23	91	6	encounter	encounter	VERB
bptjm-23	91	7	problems	problem	NOUN
bptjm-23	91	8	with	with	ADP
bptjm-23	91	9	penetrating	penetrate	VERB
bptjm-23	91	10	surfactant	surfactant	NOUN
bptjm-23	91	11	and	and	CCONJ
bptjm-23	91	12	mucosal	mucosal	NOUN
bptjm-23	91	13	layers	layer	NOUN
bptjm-23	91	14	due	due	ADP
bptjm-23	91	15	to	to	ADP
bptjm-23	91	16	degradation	degradation	NOUN
bptjm-23	91	17	and	and	CCONJ
bptjm-23	91	18	dissociation	dissociation	NOUN
bptjm-23	91	19	.	.	PUNCT
bptjm-23	92	1	modi	modi	PROPN
bptjm-23	92	2	�	�	PROPN
bptjm-23	92	3	cations	cation	NOUN
bptjm-23	92	4	can	can	AUX
bptjm-23	92	5	be	be	AUX
bptjm-23	92	6	made	make	VERB
bptjm-23	92	7	to	to	ADP
bptjm-23	92	8	nps	nps	PROPN
bptjm-23	92	9	to	to	PART
bptjm-23	92	10	resist	resist	VERB
bptjm-23	92	11	mucoadhesion	mucoadhesion	NOUN
bptjm-23	92	12	and	and	CCONJ
bptjm-23	92	13	trapping	trap	VERB
bptjm-23	92	14	or	or	CCONJ
bptjm-23	92	15	degradation	degradation	NOUN
bptjm-23	92	16	that	that	PRON
bptjm-23	92	17	may	may	AUX
bptjm-23	92	18	otherwise	otherwise	ADV
bptjm-23	92	19	occur	occur	VERB
bptjm-23	92	20	.	.	PUNCT
bptjm-23	93	1	one	one	NUM
bptjm-23	93	2	of	of	ADP
bptjm-23	93	3	the	the	DET
bptjm-23	93	4	most	most	ADV
bptjm-23	93	5	common	common	ADJ
bptjm-23	93	6	methods	method	NOUN
bptjm-23	93	7	for	for	ADP
bptjm-23	93	8	this	this	PRON
bptjm-23	93	9	is	be	AUX
bptjm-23	93	10	a	a	DET
bptjm-23	93	11	coating	coating	NOUN
bptjm-23	93	12	of	of	ADP
bptjm-23	93	13	polyethylene	polyethylene	NOUN
bptjm-23	93	14	glycol	glycol	NOUN
bptjm-23	93	15	(	(	PUNCT
bptjm-23	93	16	peg	peg	NOUN
bptjm-23	93	17	)	)	PUNCT
bptjm-23	93	18	polymer	polymer	NOUN
bptjm-23	93	19	to	to	PART
bptjm-23	93	20	provide	provide	VERB
bptjm-23	93	21	a	a	DET
bptjm-23	93	22	hydrophilic	hydrophilic	ADJ
bptjm-23	93	23	and	and	CCONJ
bptjm-23	93	24	neutral	neutral	ADJ
bptjm-23	93	25	coating	coating	NOUN
bptjm-23	93	26	to	to	PART
bptjm-23	93	27	counteract	counteract	VERB
bptjm-23	93	28	traditional	traditional	ADJ
bptjm-23	93	29	charge	charge	NOUN
bptjm-23	93	30	based	base	VERB
bptjm-23	93	31	dynamics	dynamic	NOUN
bptjm-23	93	32	used	use	VERB
bptjm-23	93	33	in	in	ADP
bptjm-23	93	34	synthesis18	synthesis18	NOUN
bptjm-23	93	35	.	.	PUNCT
bptjm-23	94	1	it	it	PRON
bptjm-23	94	2	has	have	AUX
bptjm-23	94	3	been	be	AUX
bptjm-23	94	4	found	find	VERB
bptjm-23	94	5	that	that	SCONJ
bptjm-23	94	6	these	these	DET
bptjm-23	94	7	peg	peg	NOUN
bptjm-23	94	8	coatings	coating	NOUN
bptjm-23	94	9	provide	provide	VERB
bptjm-23	94	10	varying	vary	VERB
bptjm-23	94	11	levels	level	NOUN
bptjm-23	94	12	of	of	ADP
bptjm-23	94	13	improvement	improvement	NOUN
bptjm-23	94	14	in	in	ADP
bptjm-23	94	15	penetration	penetration	NOUN
bptjm-23	94	16	of	of	ADP
bptjm-23	94	17	the	the	DET
bptjm-23	94	18	thick	thick	ADJ
bptjm-23	94	19	mucus	mucus	NOUN
bptjm-23	94	20	that	that	PRON
bptjm-23	94	21	exacerbates	exacerbate	VERB
bptjm-23	94	22	the	the	DET
bptjm-23	94	23	issue	issue	NOUN
bptjm-23	94	24	of	of	ADP
bptjm-23	94	25	access	access	NOUN
bptjm-23	94	26	to	to	ADP
bptjm-23	94	27	airway	airway	NOUN
bptjm-23	94	28	epithelial	epithelial	ADJ
bptjm-23	94	29	cells	cell	NOUN
bptjm-23	94	30	in	in	ADP
bptjm-23	94	31	patients	patient	NOUN
bptjm-23	94	32	with	with	ADP
bptjm-23	94	33	advanced	advanced	ADJ
bptjm-23	94	34	copd	copd	NOUN
bptjm-23	94	35	;	;	PUNCT
bptjm-23	94	36	degraded	degraded	ADJ
bptjm-23	94	37	structures	structure	NOUN
bptjm-23	94	38	such	such	ADJ
bptjm-23	94	39	as	as	ADP
bptjm-23	94	40	neutrophils	neutrophil	NOUN
bptjm-23	94	41	and	and	CCONJ
bptjm-23	94	42	dense	dense	ADJ
bptjm-23	94	43	meshes	mesh	NOUN
bptjm-23	94	44	of	of	ADP
bptjm-23	94	45	highly	highly	ADV
bptjm-23	94	46	negative	negative	ADJ
bptjm-23	94	47	charged	charge	VERB
bptjm-23	94	48	structures	structure	NOUN
bptjm-23	94	49	create	create	VERB
bptjm-23	94	50	a	a	DET
bptjm-23	94	51	less	less	ADV
bptjm-23	94	52	permeable	permeable	ADJ
bptjm-23	94	53	mucus	mucus	NOUN
bptjm-23	94	54	layer19,20	layer19,20	PROPN
bptjm-23	94	55	.	.	PUNCT
bptjm-23	95	1	these	these	DET
bptjm-23	95	2	�	�	PROPN
bptjm-23	95	3	ndings	nding	NOUN
bptjm-23	95	4	further	far	ADV
bptjm-23	95	5	the	the	DET
bptjm-23	95	6	ability	ability	NOUN
bptjm-23	95	7	to	to	PART
bptjm-23	95	8	overcome	overcome	VERB
bptjm-23	95	9	airway	airway	NOUN
bptjm-23	95	10	mucus	mucus	NOUN
bptjm-23	95	11	,	,	PUNCT
bptjm-23	95	12	one	one	NUM
bptjm-23	95	13	of	of	ADP
bptjm-23	95	14	the	the	DET
bptjm-23	95	15	primary	primary	ADJ
bptjm-23	95	16	issues	issue	NOUN
bptjm-23	95	17	in	in	ADP
bptjm-23	95	18	inhalable	inhalable	ADJ
bptjm-23	95	19	gene	gene	NOUN
bptjm-23	95	20	therapy	therapy	NOUN
bptjm-23	95	21	to	to	PART
bptjm-23	95	22	treat	treat	VERB
bptjm-23	95	23	copd	copd	NOUN
bptjm-23	95	24	and	and	CCONJ
bptjm-23	95	25	prevent	prevent	VERB
bptjm-23	95	26	signi	signi	PROPN
bptjm-23	95	27	�	�	NOUN
bptjm-23	95	28	cant	cant	VERB
bptjm-23	95	29	worsening	worsening	NOUN
bptjm-23	95	30	of	of	ADP
bptjm-23	95	31	symptoms	symptom	NOUN
bptjm-23	95	32	.	.	PUNCT
bptjm-23	96	1	plga	plga	VERB
bptjm-23	96	2	a	a	DET
bptjm-23	96	3	candidate	candidate	NOUN
bptjm-23	96	4	in	in	ADP
bptjm-23	96	5	gene	gene	NOUN
bptjm-23	96	6	therapy	therapy	NOUN
bptjm-23	96	7	using	use	VERB
bptjm-23	96	8	nps	nps	PROPN
bptjm-23	96	9	is	be	AUX
bptjm-23	96	10	that	that	PRON
bptjm-23	96	11	of	of	ADP
bptjm-23	96	12	poly	poly	ADJ
bptjm-23	96	13	(	(	PUNCT
bptjm-23	96	14	(	(	PUNCT
bptjm-23	96	15	d	d	NOUN
bptjm-23	96	16	,	,	PUNCT
bptjm-23	96	17	l	l	ADJ
bptjm-23	96	18	-	-	ADJ
bptjm-23	96	19	lactide	lactide	NOUN
bptjm-23	96	20	-	-	PUNCT
bptjm-23	96	21	co	co	NOUN
bptjm-23	96	22	-	-	NOUN
bptjm-23	96	23	glycolide	glycolide	ADJ
bptjm-23	96	24	)	)	PUNCT
bptjm-23	96	25	(	(	PUNCT
bptjm-23	96	26	plga	plga	NOUN
bptjm-23	96	27	)	)	PUNCT
bptjm-23	96	28	)	)	PUNCT
bptjm-23	96	29	based	base	VERB
bptjm-23	96	30	nanoparticles	nanoparticle	NOUN
bptjm-23	96	31	.	.	PUNCT
bptjm-23	97	1	plga	plga	NOUN
bptjm-23	97	2	-	-	PUNCT
bptjm-23	97	3	nps	nps	PROPN
bptjm-23	97	4	are	be	AUX
bptjm-23	97	5	fda	fda	PROPN
bptjm-23	97	6	and	and	CCONJ
bptjm-23	97	7	european	european	PROPN
bptjm-23	97	8	medicine	medicine	PROPN
bptjm-23	97	9	agency	agency	NOUN
bptjm-23	97	10	approved	approve	VERB
bptjm-23	97	11	for	for	ADP
bptjm-23	97	12	drug	drug	NOUN
bptjm-23	97	13	delivery	delivery	NOUN
bptjm-23	97	14	systems	system	NOUN
bptjm-23	97	15	,	,	PUNCT
bptjm-23	97	16	not	not	PART
bptjm-23	97	17	gene	gene	NOUN
bptjm-23	97	18	delivery	delivery	NOUN
bptjm-23	97	19	.	.	PUNCT
bptjm-23	98	1	good	good	ADJ
bptjm-23	98	2	results	result	NOUN
bptjm-23	98	3	have	have	AUX
bptjm-23	98	4	been	be	AUX
bptjm-23	98	5	demonstrated	demonstrate	VERB
bptjm-23	98	6	regarding	regard	VERB
bptjm-23	98	7	biocompatibility	biocompatibility	NOUN
bptjm-23	98	8	that	that	PRON
bptjm-23	98	9	exceeds	exceed	VERB
bptjm-23	98	10	that	that	PRON
bptjm-23	98	11	of	of	ADP
bptjm-23	98	12	common	common	ADJ
bptjm-23	98	13	liposome	liposome	NOUN
bptjm-23	98	14	based	base	VERB
bptjm-23	98	15	treatments	treatment	NOUN
bptjm-23	98	16	in	in	ADP
bptjm-23	98	17	transfection	transfection	NOUN
bptjm-23	98	18	of	of	ADP
bptjm-23	98	19	hepg2	hepg2	NOUN
bptjm-23	98	20	cells	cell	NOUN
bptjm-23	98	21	for	for	ADP
bptjm-23	98	22	gene	gene	NOUN
bptjm-23	98	23	delivery21,22	delivery21,22	NOUN
bptjm-23	98	24	.	.	PUNCT
bptjm-23	99	1	surface	surface	PROPN
bptjm-23	99	2	modi	modi	PROPN
bptjm-23	99	3	�	�	PROPN
bptjm-23	99	4	cations	cation	NOUN
bptjm-23	99	5	can	can	AUX
bptjm-23	99	6	be	be	AUX
bptjm-23	99	7	made	make	VERB
bptjm-23	99	8	to	to	PART
bptjm-23	99	9	plga	plga	VERB
bptjm-23	99	10	-	-	PUNCT
bptjm-23	99	11	nps	nps	PROPN
bptjm-23	99	12	to	to	PART
bptjm-23	99	13	enhance	enhance	VERB
bptjm-23	99	14	e	e	NOUN
bptjm-23	99	15	�	�	NOUN
bptjm-23	99	16	ciency	ciency	NOUN
bptjm-23	99	17	in	in	ADP
bptjm-23	99	18	performance	performance	NOUN
bptjm-23	99	19	such	such	ADJ
bptjm-23	99	20	as	as	ADP
bptjm-23	99	21	the	the	DET
bptjm-23	99	22	addition	addition	NOUN
bptjm-23	99	23	of	of	ADP
bptjm-23	99	24	polyethyleneimine	polyethyleneimine	PROPN
bptjm-23	99	25	(	(	PUNCT
bptjm-23	99	26	pei	pei	PROPN
bptjm-23	99	27	)	)	PUNCT
bptjm-23	99	28	made	make	VERB
bptjm-23	99	29	by	by	ADP
bptjm-23	99	30	bivas	biva	NOUN
bptjm-23	99	31	-	-	PUNCT
bptjm-23	99	32	benita	benita	PROPN
bptjm-23	99	33	et	et	PROPN
bptjm-23	99	34	al	al	PROPN
bptjm-23	99	35	.	.	PUNCT
bptjm-23	99	36	to	to	PART
bptjm-23	99	37	enhance	enhance	VERB
bptjm-23	99	38	performance	performance	NOUN
bptjm-23	99	39	in	in	ADP
bptjm-23	99	40	the	the	DET
bptjm-23	99	41	pulmonary	pulmonary	ADJ
bptjm-23	99	42	system	system	NOUN
bptjm-23	99	43	given	give	VERB
bptjm-23	99	44	its	its	PRON
bptjm-23	99	45	merits	merit	NOUN
bptjm-23	99	46	as	as	ADP
bptjm-23	99	47	a	a	DET
bptjm-23	99	48	gene	gene	NOUN
bptjm-23	99	49	delivery	delivery	NOUN
bptjm-23	99	50	berkeley	berkeley	PROPN
bptjm-23	99	51	pharma	pharma	PROPN
bptjm-23	99	52	tech	tech	NOUN
bptjm-23	99	53	journal	journal	NOUN
bptjm-23	99	54	of	of	ADP
bptjm-23	99	55	medicine	medicine	NOUN
bptjm-23	99	56	|	|	ADV
bptjm-23	99	57	66	66	NUM
bptjm-23	99	58	vector	vector	NOUN
bptjm-23	99	59	;	;	PUNCT
bptjm-23	99	60	the	the	DET
bptjm-23	99	61	particles	particle	NOUN
bptjm-23	99	62	were	be	AUX
bptjm-23	99	63	seen	see	VERB
bptjm-23	99	64	to	to	PART
bptjm-23	99	65	escape	escape	VERB
bptjm-23	99	66	the	the	DET
bptjm-23	99	67	endolysosomal	endolysosomal	ADJ
bptjm-23	99	68	envelope	envelope	NOUN
bptjm-23	99	69	and	and	CCONJ
bptjm-23	99	70	subsequent	subsequent	ADJ
bptjm-23	99	71	damage	damage	NOUN
bptjm-23	99	72	to	to	PART
bptjm-23	99	73	continue	continue	VERB
bptjm-23	99	74	release	release	NOUN
bptjm-23	99	75	of	of	ADP
bptjm-23	99	76	material	material	NOUN
bptjm-23	99	77	in	in	ADP
bptjm-23	99	78	some	some	DET
bptjm-23	99	79	instances	instance	NOUN
bptjm-23	99	80	as	as	ADP
bptjm-23	99	81	well23	well23	NOUN
bptjm-23	99	82	.	.	PUNCT
bptjm-23	100	1	dendrimers	dendrimer	NOUN
bptjm-23	100	2	a	a	DET
bptjm-23	100	3	relatively	relatively	ADV
bptjm-23	100	4	unique	unique	ADJ
bptjm-23	100	5	np	np	ADP
bptjm-23	100	6	structure	structure	NOUN
bptjm-23	100	7	that	that	PRON
bptjm-23	100	8	has	have	AUX
bptjm-23	100	9	gained	gain	VERB
bptjm-23	100	10	exposure	exposure	NOUN
bptjm-23	100	11	in	in	ADP
bptjm-23	100	12	gene	gene	NOUN
bptjm-23	100	13	therapy	therapy	NOUN
bptjm-23	100	14	treatment	treatment	NOUN
bptjm-23	100	15	given	give	VERB
bptjm-23	100	16	success	success	NOUN
bptjm-23	100	17	in	in	ADP
bptjm-23	100	18	diagnostics	diagnostic	NOUN
bptjm-23	100	19	is	be	AUX
bptjm-23	100	20	dendrimers	dendrimer	NOUN
bptjm-23	100	21	.	.	PUNCT
bptjm-23	101	1	these	these	DET
bptjm-23	101	2	nps	nps	PROPN
bptjm-23	101	3	are	be	AUX
bptjm-23	101	4	based	base	VERB
bptjm-23	101	5	on	on	ADP
bptjm-23	101	6	the	the	DET
bptjm-23	101	7	dendrimer	dendrimer	NOUN
bptjm-23	101	8	polymers	polymer	NOUN
bptjm-23	101	9	that	that	PRON
bptjm-23	101	10	exhibit	exhibit	VERB
bptjm-23	101	11	a	a	DET
bptjm-23	101	12	radially	radially	ADV
bptjm-23	101	13	symmetric	symmetric	ADJ
bptjm-23	101	14	pattern	pattern	NOUN
bptjm-23	101	15	of	of	ADP
bptjm-23	101	16	branching	branch	VERB
bptjm-23	101	17	chains	chain	NOUN
bptjm-23	101	18	.	.	PUNCT
bptjm-23	102	1	this	this	PRON
bptjm-23	102	2	allows	allow	VERB
bptjm-23	102	3	for	for	ADP
bptjm-23	102	4	many	many	ADJ
bptjm-23	102	5	exposed	expose	VERB
bptjm-23	102	6	ends	end	NOUN
bptjm-23	102	7	at	at	ADP
bptjm-23	102	8	the	the	DET
bptjm-23	102	9	surface	surface	NOUN
bptjm-23	102	10	that	that	PRON
bptjm-23	102	11	can	can	AUX
bptjm-23	102	12	be	be	AUX
bptjm-23	102	13	modi	modi	PROPN
bptjm-23	102	14	�	�	X
bptjm-23	102	15	ed	ed	NOUN
bptjm-23	102	16	much	much	ADV
bptjm-23	102	17	like	like	ADP
bptjm-23	102	18	other	other	ADJ
bptjm-23	102	19	nps	nps	PROPN
bptjm-23	102	20	to	to	PART
bptjm-23	102	21	optimize	optimize	VERB
bptjm-23	102	22	their	their	PRON
bptjm-23	102	23	function	function	NOUN
bptjm-23	102	24	as	as	ADP
bptjm-23	102	25	a	a	DET
bptjm-23	102	26	delivery	delivery	NOUN
bptjm-23	102	27	method	method	NOUN
bptjm-23	102	28	for	for	ADP
bptjm-23	102	29	genetic	genetic	ADJ
bptjm-23	102	30	material	material	NOUN
bptjm-23	102	31	.	.	PUNCT
bptjm-23	103	1	hypotheses	hypothesis	NOUN
bptjm-23	103	2	revolve	revolve	VERB
bptjm-23	103	3	around	around	ADP
bptjm-23	103	4	the	the	DET
bptjm-23	103	5	potential	potential	NOUN
bptjm-23	103	6	for	for	SCONJ
bptjm-23	103	7	these	these	DET
bptjm-23	103	8	large	large	ADJ
bptjm-23	103	9	amounts	amount	NOUN
bptjm-23	103	10	of	of	ADP
bptjm-23	103	11	ionizable	ionizable	ADJ
bptjm-23	103	12	branches	branch	NOUN
bptjm-23	103	13	to	to	PART
bptjm-23	103	14	be	be	AUX
bptjm-23	103	15	modi	modi	PROPN
bptjm-23	103	16	�	�	NOUN
bptjm-23	103	17	ed	ed	NOUN
bptjm-23	103	18	,	,	PUNCT
bptjm-23	103	19	most	most	ADV
bptjm-23	103	20	commonly	commonly	ADV
bptjm-23	103	21	utilizing	utilize	VERB
bptjm-23	103	22	poly-(amidoamine	poly-(amidoamine	NOUN
bptjm-23	103	23	)	)	PUNCT
bptjm-23	103	24	and	and	CCONJ
bptjm-23	103	25	poly-(propyleneimine	poly-(propyleneimine	NOUN
bptjm-23	103	26	)	)	PUNCT
bptjm-23	103	27	as	as	ADP
bptjm-23	103	28	a	a	DET
bptjm-23	103	29	base	base	NOUN
bptjm-23	103	30	,	,	PUNCT
bptjm-23	103	31	or	or	CCONJ
bptjm-23	103	32	immediately	immediately	ADV
bptjm-23	103	33	paired	pair	VERB
bptjm-23	103	34	with	with	ADP
bptjm-23	103	35	genetic	genetic	ADJ
bptjm-23	103	36	material	material	NOUN
bptjm-23	103	37	for	for	ADP
bptjm-23	103	38	testing29	testing29	NOUN
bptjm-23	103	39	.	.	PUNCT
bptjm-23	104	1	to	to	PART
bptjm-23	104	2	help	help	VERB
bptjm-23	104	3	in	in	ADP
bptjm-23	104	4	structure	structure	NOUN
bptjm-23	104	5	stability	stability	NOUN
bptjm-23	104	6	and	and	CCONJ
bptjm-23	104	7	formation	formation	VERB
bptjm-23	104	8	the	the	DET
bptjm-23	104	9	aforementioned	aforementioned	ADJ
bptjm-23	104	10	peg	peg	NOUN
bptjm-23	104	11	coating	coating	NOUN
bptjm-23	104	12	is	be	AUX
bptjm-23	104	13	applied	apply	VERB
bptjm-23	104	14	to	to	ADP
bptjm-23	104	15	dendrimer	dendrimer	PROPN
bptjm-23	104	16	nps	nps	PROPN
bptjm-23	104	17	prior	prior	ADV
bptjm-23	104	18	to	to	ADP
bptjm-23	104	19	material	material	NOUN
bptjm-23	104	20	attachment1	attachment1	PROPN
bptjm-23	104	21	.	.	PUNCT
bptjm-23	105	1	given	give	VERB
bptjm-23	105	2	the	the	DET
bptjm-23	105	3	plentiful	plentiful	ADJ
bptjm-23	105	4	terminals	terminal	NOUN
bptjm-23	105	5	,	,	PUNCT
bptjm-23	105	6	rapid	rapid	ADJ
bptjm-23	105	7	absorption	absorption	NOUN
bptjm-23	105	8	and	and	CCONJ
bptjm-23	105	9	dissipation	dissipation	NOUN
bptjm-23	105	10	of	of	ADP
bptjm-23	105	11	the	the	DET
bptjm-23	105	12	nps	nps	PROPN
bptjm-23	105	13	is	be	AUX
bptjm-23	105	14	another	another	DET
bptjm-23	105	15	problem	problem	NOUN
bptjm-23	105	16	solved	solve	VERB
bptjm-23	105	17	via	via	ADP
bptjm-23	105	18	these	these	DET
bptjm-23	105	19	peg	peg	NOUN
bptjm-23	105	20	coatings	coating	NOUN
bptjm-23	105	21	by	by	ADP
bptjm-23	105	22	enhancing	enhance	VERB
bptjm-23	105	23	retention	retention	NOUN
bptjm-23	105	24	by	by	ADP
bptjm-23	105	25	the	the	DET
bptjm-23	105	26	lung	lung	NOUN
bptjm-23	105	27	tissue	tissue	NOUN
bptjm-23	105	28	.	.	PUNCT
bptjm-23	106	1	the	the	DET
bptjm-23	106	2	majority	majority	NOUN
bptjm-23	106	3	of	of	ADP
bptjm-23	106	4	the	the	DET
bptjm-23	106	5	published	publish	VERB
bptjm-23	106	6	work	work	NOUN
bptjm-23	106	7	on	on	ADP
bptjm-23	106	8	dendrimer	dendrimer	PROPN
bptjm-23	106	9	nps	nps	PROPN
bptjm-23	106	10	in	in	ADP
bptjm-23	106	11	lung	lung	NOUN
bptjm-23	106	12	tissue	tissue	NOUN
bptjm-23	106	13	gene	gene	NOUN
bptjm-23	106	14	therapy	therapy	NOUN
bptjm-23	106	15	presents	present	VERB
bptjm-23	106	16	them	they	PRON
bptjm-23	106	17	in	in	ADP
bptjm-23	106	18	the	the	DET
bptjm-23	106	19	context	context	NOUN
bptjm-23	106	20	of	of	ADP
bptjm-23	106	21	this	this	DET
bptjm-23	106	22	‘	'	PUNCT
bptjm-23	106	23	pegylation	pegylation	NOUN
bptjm-23	106	24	”	"	PUNCT
bptjm-23	106	25	given	give	VERB
bptjm-23	106	26	the	the	DET
bptjm-23	106	27	ability	ability	NOUN
bptjm-23	106	28	to	to	PART
bptjm-23	106	29	control	control	VERB
bptjm-23	106	30	uptake	uptake	ADJ
bptjm-23	106	31	with	with	ADP
bptjm-23	106	32	a	a	DET
bptjm-23	106	33	much	much	ADV
bptjm-23	106	34	higher	high	ADJ
bptjm-23	106	35	degree	degree	NOUN
bptjm-23	106	36	of	of	ADP
bptjm-23	106	37	precision	precision	NOUN
bptjm-23	106	38	than	than	ADP
bptjm-23	106	39	without30,31	without30,31	NOUN
bptjm-23	106	40	.	.	PUNCT
bptjm-23	107	1	dendrimers	dendrimer	NOUN
bptjm-23	107	2	share	share	VERB
bptjm-23	107	3	in	in	ADP
bptjm-23	107	4	the	the	DET
bptjm-23	107	5	success	success	NOUN
bptjm-23	107	6	of	of	ADP
bptjm-23	107	7	nps	nps	PROPN
bptjm-23	107	8	as	as	ADP
bptjm-23	107	9	a	a	DET
bptjm-23	107	10	whole	whole	NOUN
bptjm-23	107	11	in	in	ADP
bptjm-23	107	12	their	their	PRON
bptjm-23	107	13	continued	continue	VERB
bptjm-23	107	14	research	research	NOUN
bptjm-23	107	15	and	and	CCONJ
bptjm-23	107	16	have	have	VERB
bptjm-23	107	17	signi	signi	PROPN
bptjm-23	107	18	�	�	NOUN
bptjm-23	107	19	cant	cant	VERB
bptjm-23	107	20	potential	potential	NOUN
bptjm-23	107	21	for	for	ADP
bptjm-23	107	22	delivery	delivery	NOUN
bptjm-23	107	23	of	of	ADP
bptjm-23	107	24	gene	gene	NOUN
bptjm-23	107	25	therapy	therapy	NOUN
bptjm-23	107	26	to	to	PART
bptjm-23	107	27	inhibit	inhibit	VERB
bptjm-23	107	28	copd	copd	NOUN
bptjm-23	107	29	symptoms	symptom	NOUN
bptjm-23	107	30	provided	provide	VERB
bptjm-23	107	31	the	the	DET
bptjm-23	107	32	state	state	NOUN
bptjm-23	107	33	of	of	ADP
bptjm-23	107	34	knowledge	knowledge	NOUN
bptjm-23	107	35	continues	continue	VERB
bptjm-23	107	36	to	to	PART
bptjm-23	107	37	advance	advance	VERB
bptjm-23	107	38	.	.	PUNCT
bptjm-23	108	1	electroporation	electroporation	NOUN
bptjm-23	108	2	electroporation	electroporation	NOUN
bptjm-23	108	3	(	(	PUNCT
bptjm-23	108	4	ep	ep	PROPN
bptjm-23	108	5	)	)	PUNCT
bptjm-23	108	6	di	di	NOUN
bptjm-23	108	7	�	�	PROPN
bptjm-23	108	8	ers	er	NOUN
bptjm-23	108	9	from	from	ADP
bptjm-23	108	10	previously	previously	ADV
bptjm-23	108	11	discussed	discuss	VERB
bptjm-23	108	12	delivery	delivery	NOUN
bptjm-23	108	13	methods	method	NOUN
bptjm-23	108	14	in	in	ADP
bptjm-23	108	15	its	its	PRON
bptjm-23	108	16	physical	physical	ADJ
bptjm-23	108	17	based	base	VERB
bptjm-23	108	18	mechanism	mechanism	NOUN
bptjm-23	108	19	of	of	ADP
bptjm-23	108	20	action	action	NOUN
bptjm-23	108	21	rather	rather	ADV
bptjm-23	108	22	than	than	ADP
bptjm-23	108	23	the	the	DET
bptjm-23	108	24	chemical	chemical	ADJ
bptjm-23	108	25	basis	basis	NOUN
bptjm-23	108	26	on	on	ADP
bptjm-23	108	27	which	which	PRON
bptjm-23	108	28	nps	nps	PROPN
bptjm-23	108	29	and	and	CCONJ
bptjm-23	108	30	lipoplex	lipoplex	PROPN
bptjm-23	108	31	therapies	therapy	NOUN
bptjm-23	108	32	rely	rely	VERB
bptjm-23	108	33	.	.	PUNCT
bptjm-23	109	1	it	it	PRON
bptjm-23	109	2	has	have	AUX
bptjm-23	109	3	emerged	emerge	VERB
bptjm-23	109	4	as	as	ADP
bptjm-23	109	5	one	one	NUM
bptjm-23	109	6	of	of	ADP
bptjm-23	109	7	the	the	DET
bptjm-23	109	8	few	few	ADJ
bptjm-23	109	9	physical	physical	ADJ
bptjm-23	109	10	methods	method	NOUN
bptjm-23	109	11	researched	research	VERB
bptjm-23	109	12	for	for	ADP
bptjm-23	109	13	gene	gene	NOUN
bptjm-23	109	14	delivery	delivery	NOUN
bptjm-23	109	15	given	give	VERB
bptjm-23	109	16	its	its	PRON
bptjm-23	109	17	safety	safety	NOUN
bptjm-23	109	18	and	and	CCONJ
bptjm-23	109	19	e	e	NOUN
bptjm-23	109	20	�	�	NOUN
bptjm-23	109	21	cacy	cacy	NOUN
bptjm-23	109	22	compared	compare	VERB
bptjm-23	109	23	to	to	ADP
bptjm-23	109	24	others	other	NOUN
bptjm-23	109	25	.	.	PUNCT
bptjm-23	110	1	ep	ep	PROPN
bptjm-23	110	2	takes	take	VERB
bptjm-23	110	3	advantage	advantage	NOUN
bptjm-23	110	4	of	of	ADP
bptjm-23	110	5	an	an	DET
bptjm-23	110	6	electric	electric	PROPN
bptjm-23	110	7	�	�	PROPN
bptjm-23	110	8	eld	eld	NOUN
bptjm-23	110	9	applied	apply	VERB
bptjm-23	110	10	across	across	ADP
bptjm-23	110	11	cells	cell	NOUN
bptjm-23	110	12	to	to	PART
bptjm-23	110	13	alter	alter	VERB
bptjm-23	110	14	permeability	permeability	NOUN
bptjm-23	110	15	and	and	CCONJ
bptjm-23	110	16	allow	allow	VERB
bptjm-23	110	17	previously	previously	ADV
bptjm-23	110	18	injected	inject	VERB
bptjm-23	110	19	genetic	genetic	ADJ
bptjm-23	110	20	material	material	NOUN
bptjm-23	110	21	to	to	PART
bptjm-23	110	22	be	be	AUX
bptjm-23	110	23	more	more	ADV
bptjm-23	110	24	readily	readily	ADV
bptjm-23	110	25	endocytosed	endocytose	VERB
bptjm-23	110	26	.	.	PUNCT
bptjm-23	111	1	transfection	transfection	NOUN
bptjm-23	111	2	e	e	NOUN
bptjm-23	111	3	�	�	NOUN
bptjm-23	111	4	ciency	ciency	NOUN
bptjm-23	111	5	in	in	ADP
bptjm-23	111	6	tumors	tumor	NOUN
bptjm-23	111	7	using	use	VERB
bptjm-23	111	8	ep	ep	PROPN
bptjm-23	111	9	has	have	AUX
bptjm-23	111	10	provided	provide	VERB
bptjm-23	111	11	the	the	DET
bptjm-23	111	12	foundation	foundation	NOUN
bptjm-23	111	13	of	of	ADP
bptjm-23	111	14	knowledge	knowledge	NOUN
bptjm-23	111	15	for	for	ADP
bptjm-23	111	16	its	its	PRON
bptjm-23	111	17	usage	usage	NOUN
bptjm-23	111	18	in	in	ADP
bptjm-23	111	19	lung	lung	NOUN
bptjm-23	111	20	tissues	tissue	NOUN
bptjm-23	111	21	.	.	PUNCT
bptjm-23	112	1	intense	intense	ADJ
bptjm-23	112	2	berkeley	berkeley	PROPN
bptjm-23	112	3	pharma	pharma	PROPN
bptjm-23	112	4	tech	tech	NOUN
bptjm-23	112	5	journal	journal	NOUN
bptjm-23	112	6	of	of	ADP
bptjm-23	112	7	medicine	medicine	NOUN
bptjm-23	112	8	|	|	ADV
bptjm-23	112	9	67	67	NUM
bptjm-23	112	10	tissue	tissue	NOUN
bptjm-23	112	11	analysis	analysis	NOUN
bptjm-23	112	12	and/or	and/or	CCONJ
bptjm-23	112	13	electric	electric	PROPN
bptjm-23	112	14	�	�	PROPN
bptjm-23	112	15	eld	eld	PROPN
bptjm-23	112	16	testing	testing	NOUN
bptjm-23	112	17	is	be	AUX
bptjm-23	112	18	required	require	VERB
bptjm-23	112	19	in	in	ADP
bptjm-23	112	20	most	most	ADJ
bptjm-23	112	21	cases	case	NOUN
bptjm-23	112	22	to	to	PART
bptjm-23	112	23	ensure	ensure	VERB
bptjm-23	112	24	optimal	optimal	ADJ
bptjm-23	112	25	settings	setting	NOUN
bptjm-23	112	26	given	give	VERB
bptjm-23	112	27	the	the	DET
bptjm-23	112	28	natural	natural	ADJ
bptjm-23	112	29	variation	variation	NOUN
bptjm-23	112	30	in	in	ADP
bptjm-23	112	31	biological	biological	ADJ
bptjm-23	112	32	tissues32	tissues32	NOUN
bptjm-23	112	33	.	.	PUNCT
bptjm-23	113	1	traditional	traditional	ADJ
bptjm-23	113	2	chemical	chemical	NOUN
bptjm-23	113	3	based	base	VERB
bptjm-23	113	4	approaches	approach	NOUN
bptjm-23	113	5	make	make	VERB
bptjm-23	113	6	up	up	ADP
bptjm-23	113	7	the	the	DET
bptjm-23	113	8	vast	vast	ADJ
bptjm-23	113	9	majority	majority	NOUN
bptjm-23	113	10	of	of	ADP
bptjm-23	113	11	research	research	NOUN
bptjm-23	113	12	due	due	ADP
bptjm-23	113	13	to	to	ADP
bptjm-23	113	14	customizability	customizability	NOUN
bptjm-23	113	15	.	.	PUNCT
bptjm-23	114	1	however	however	ADV
bptjm-23	114	2	,	,	PUNCT
bptjm-23	114	3	as	as	SCONJ
bptjm-23	114	4	these	these	DET
bptjm-23	114	5	�	�	PROPN
bptjm-23	114	6	elds	eld	NOUN
bptjm-23	114	7	move	move	VERB
bptjm-23	114	8	forward	forward	ADV
bptjm-23	114	9	experiments	experiment	NOUN
bptjm-23	114	10	have	have	AUX
bptjm-23	114	11	validated	validate	VERB
bptjm-23	114	12	ep	ep	PROPN
bptjm-23	114	13	as	as	ADP
bptjm-23	114	14	a	a	DET
bptjm-23	114	15	comparably	comparably	ADV
bptjm-23	114	16	e	e	ADJ
bptjm-23	114	17	�	�	NOUN
bptjm-23	114	18	ective	ective	ADJ
bptjm-23	114	19	method	method	NOUN
bptjm-23	114	20	when	when	SCONJ
bptjm-23	114	21	physiological	physiological	ADJ
bptjm-23	114	22	responses	response	NOUN
bptjm-23	114	23	are	be	AUX
bptjm-23	114	24	considered	consider	VERB
bptjm-23	114	25	in	in	ADP
bptjm-23	114	26	tandem	tandem	NOUN
bptjm-23	114	27	with	with	ADP
bptjm-23	114	28	pure	pure	ADJ
bptjm-23	114	29	gene	gene	NOUN
bptjm-23	114	30	expression	expression	NOUN
bptjm-23	114	31	amongst	amongst	ADP
bptjm-23	114	32	cells33	cells33	NOUN
bptjm-23	114	33	.	.	PUNCT
bptjm-23	115	1	viral	viral	ADJ
bptjm-23	115	2	methods	method	NOUN
bptjm-23	115	3	viral	viral	ADJ
bptjm-23	115	4	vectors	vector	NOUN
bptjm-23	115	5	have	have	AUX
bptjm-23	115	6	been	be	AUX
bptjm-23	115	7	researched	research	VERB
bptjm-23	115	8	as	as	ADP
bptjm-23	115	9	avenues	avenue	NOUN
bptjm-23	115	10	for	for	ADP
bptjm-23	115	11	gene	gene	NOUN
bptjm-23	115	12	therapy	therapy	NOUN
bptjm-23	115	13	for	for	ADP
bptjm-23	115	14	years	year	NOUN
bptjm-23	115	15	now	now	ADV
bptjm-23	115	16	given	give	VERB
bptjm-23	115	17	their	their	PRON
bptjm-23	115	18	development	development	NOUN
bptjm-23	115	19	in	in	ADP
bptjm-23	115	20	the	the	DET
bptjm-23	115	21	early	early	ADJ
bptjm-23	115	22	1970s	1970	NOUN
bptjm-23	115	23	and	and	CCONJ
bptjm-23	115	24	80s	80	NOUN
bptjm-23	115	25	and	and	CCONJ
bptjm-23	115	26	ability	ability	NOUN
bptjm-23	115	27	to	to	PART
bptjm-23	115	28	take	take	VERB
bptjm-23	115	29	advantage	advantage	NOUN
bptjm-23	115	30	of	of	ADP
bptjm-23	115	31	mechanisms	mechanism	NOUN
bptjm-23	115	32	native	native	ADJ
bptjm-23	115	33	to	to	ADP
bptjm-23	115	34	the	the	DET
bptjm-23	115	35	viruses	virus	NOUN
bptjm-23	115	36	themselves	themselves	PRON
bptjm-23	115	37	.	.	PUNCT
bptjm-23	116	1	the	the	DET
bptjm-23	116	2	primary	primary	ADJ
bptjm-23	116	3	vector	vector	NOUN
bptjm-23	116	4	types	type	NOUN
bptjm-23	116	5	found	find	VERB
bptjm-23	116	6	in	in	ADP
bptjm-23	116	7	modern	modern	ADJ
bptjm-23	116	8	gene	gene	NOUN
bptjm-23	116	9	therapy	therapy	NOUN
bptjm-23	116	10	for	for	ADP
bptjm-23	116	11	copd	copd	PROPN
bptjm-23	116	12	and	and	CCONJ
bptjm-23	116	13	lung	lung	NOUN
bptjm-23	116	14	tissue	tissue	NOUN
bptjm-23	116	15	oriented	orient	VERB
bptjm-23	116	16	studies	study	NOUN
bptjm-23	116	17	are	be	AUX
bptjm-23	116	18	adenovirus	adenovirus	NOUN
bptjm-23	116	19	and	and	CCONJ
bptjm-23	116	20	adeno	adeno	NOUN
bptjm-23	116	21	-	-	PUNCT
bptjm-23	116	22	associated	associate	VERB
bptjm-23	116	23	virus	virus	NOUN
bptjm-23	116	24	(	(	PUNCT
bptjm-23	116	25	aav	aav	NOUN
bptjm-23	116	26	)	)	PUNCT
bptjm-23	116	27	based	base	VERB
bptjm-23	116	28	approaches	approach	NOUN
bptjm-23	116	29	.	.	PUNCT
bptjm-23	117	1	the	the	DET
bptjm-23	117	2	di	di	PROPN
bptjm-23	117	3	�	�	PROPN
bptjm-23	117	4	erences	erence	NOUN
bptjm-23	117	5	in	in	ADP
bptjm-23	117	6	viral	viral	ADJ
bptjm-23	117	7	vectors	vector	NOUN
bptjm-23	117	8	and	and	CCONJ
bptjm-23	117	9	e	e	NOUN
bptjm-23	117	10	�	�	NOUN
bptjm-23	117	11	cacy	cacy	NOUN
bptjm-23	117	12	is	be	AUX
bptjm-23	117	13	contingent	contingent	ADJ
bptjm-23	117	14	on	on	ADP
bptjm-23	117	15	the	the	DET
bptjm-23	117	16	exact	exact	ADJ
bptjm-23	117	17	protein	protein	NOUN
bptjm-23	117	18	capsid	capsid	NOUN
bptjm-23	117	19	and	and	CCONJ
bptjm-23	117	20	tissue	tissue	NOUN
bptjm-23	117	21	tropism	tropism	NOUN
bptjm-23	117	22	,	,	PUNCT
bptjm-23	117	23	the	the	DET
bptjm-23	117	24	gene	gene	NOUN
bptjm-23	117	25	of	of	ADP
bptjm-23	117	26	interest	interest	NOUN
bptjm-23	117	27	for	for	ADP
bptjm-23	117	28	therapeutic	therapeutic	ADJ
bptjm-23	117	29	purposes	purpose	NOUN
bptjm-23	117	30	,	,	PUNCT
bptjm-23	117	31	and	and	CCONJ
bptjm-23	117	32	the	the	DET
bptjm-23	117	33	alterations	alteration	NOUN
bptjm-23	117	34	that	that	PRON
bptjm-23	117	35	control	control	VERB
bptjm-23	117	36	the	the	DET
bptjm-23	117	37	gene	gene	NOUN
bptjm-23	117	38	expression	expression	NOUN
bptjm-23	117	39	for	for	ADP
bptjm-23	117	40	the	the	DET
bptjm-23	117	41	vector34	vector34	NOUN
bptjm-23	117	42	.	.	PUNCT
bptjm-23	118	1	these	these	DET
bptjm-23	118	2	work	work	VERB
bptjm-23	118	3	together	together	ADV
bptjm-23	118	4	and	and	CCONJ
bptjm-23	118	5	can	can	AUX
bptjm-23	118	6	be	be	AUX
bptjm-23	118	7	chosen	choose	VERB
bptjm-23	118	8	or	or	CCONJ
bptjm-23	118	9	altered	alter	VERB
bptjm-23	118	10	to	to	PART
bptjm-23	118	11	perfect	perfect	VERB
bptjm-23	118	12	one	one	NUM
bptjm-23	118	13	’s	’s	PART
bptjm-23	118	14	vector	vector	NOUN
bptjm-23	118	15	for	for	ADP
bptjm-23	118	16	its	its	PRON
bptjm-23	118	17	desired	desire	VERB
bptjm-23	118	18	purpose	purpose	NOUN
bptjm-23	118	19	.	.	PUNCT
bptjm-23	119	1	common	common	ADJ
bptjm-23	119	2	problems	problem	NOUN
bptjm-23	119	3	brought	bring	VERB
bptjm-23	119	4	about	about	ADP
bptjm-23	119	5	in	in	ADP
bptjm-23	119	6	viral	viral	ADJ
bptjm-23	119	7	vector	vector	NOUN
bptjm-23	119	8	usage	usage	NOUN
bptjm-23	119	9	despite	despite	SCONJ
bptjm-23	119	10	modi	modi	PROPN
bptjm-23	119	11	�	�	PROPN
bptjm-23	119	12	cations	cation	NOUN
bptjm-23	119	13	is	be	AUX
bptjm-23	119	14	the	the	DET
bptjm-23	119	15	innate	innate	ADJ
bptjm-23	119	16	immune	immune	ADJ
bptjm-23	119	17	response	response	NOUN
bptjm-23	119	18	.	.	PUNCT
bptjm-23	120	1	t	t	NOUN
bptjm-23	120	2	-	-	PUNCT
bptjm-23	120	3	cell	cell	NOUN
bptjm-23	120	4	responses	response	NOUN
bptjm-23	120	5	and	and	CCONJ
bptjm-23	120	6	toxicity	toxicity	NOUN
bptjm-23	120	7	within	within	ADP
bptjm-23	120	8	tissue	tissue	NOUN
bptjm-23	120	9	is	be	AUX
bptjm-23	120	10	a	a	DET
bptjm-23	120	11	cause	cause	NOUN
bptjm-23	120	12	of	of	ADP
bptjm-23	120	13	viruses	virus	NOUN
bptjm-23	120	14	that	that	PRON
bptjm-23	120	15	has	have	AUX
bptjm-23	120	16	developed	develop	VERB
bptjm-23	120	17	to	to	PART
bptjm-23	120	18	help	help	VERB
bptjm-23	120	19	the	the	DET
bptjm-23	120	20	body	body	NOUN
bptjm-23	120	21	respond	respond	VERB
bptjm-23	120	22	.	.	PUNCT
bptjm-23	121	1	however	however	ADV
bptjm-23	121	2	,	,	PUNCT
bptjm-23	121	3	redesign	redesign	NOUN
bptjm-23	121	4	and	and	CCONJ
bptjm-23	121	5	manipulation	manipulation	NOUN
bptjm-23	121	6	of	of	ADP
bptjm-23	121	7	these	these	DET
bptjm-23	121	8	viral	viral	ADJ
bptjm-23	121	9	genomes	genome	NOUN
bptjm-23	121	10	and	and	CCONJ
bptjm-23	121	11	bodies	body	NOUN
bptjm-23	121	12	can	can	AUX
bptjm-23	121	13	still	still	ADV
bptjm-23	121	14	carry	carry	VERB
bptjm-23	121	15	markers	marker	NOUN
bptjm-23	121	16	to	to	PART
bptjm-23	121	17	inhibit	inhibit	VERB
bptjm-23	121	18	their	their	PRON
bptjm-23	121	19	expression	expression	NOUN
bptjm-23	121	20	when	when	SCONJ
bptjm-23	121	21	used	use	VERB
bptjm-23	121	22	as	as	ADP
bptjm-23	121	23	vehicles	vehicle	NOUN
bptjm-23	121	24	for	for	ADP
bptjm-23	121	25	gene	gene	NOUN
bptjm-23	121	26	therapy	therapy	NOUN
bptjm-23	121	27	.	.	PUNCT
bptjm-23	122	1	adenoviruses	adenovirus	NOUN
bptjm-23	122	2	with	with	ADP
bptjm-23	122	3	regard	regard	NOUN
bptjm-23	122	4	to	to	ADP
bptjm-23	122	5	the	the	DET
bptjm-23	122	6	aforementioned	aforementioned	ADJ
bptjm-23	122	7	characteristics	characteristic	NOUN
bptjm-23	122	8	adenoviruses	adenovirus	NOUN
bptjm-23	122	9	are	be	AUX
bptjm-23	122	10	a	a	DET
bptjm-23	122	11	family	family	NOUN
bptjm-23	122	12	of	of	ADP
bptjm-23	122	13	icosahedral	icosahedral	ADJ
bptjm-23	122	14	nucleocapsid	nucleocapsid	ADJ
bptjm-23	122	15	viruses	virus	NOUN
bptjm-23	122	16	.	.	PUNCT
bptjm-23	123	1	they	they	PRON
bptjm-23	123	2	are	be	AUX
bptjm-23	123	3	unenveloped	unenvelope	VERB
bptjm-23	123	4	and	and	CCONJ
bptjm-23	123	5	hence	hence	ADV
bptjm-23	123	6	carry	carry	VERB
bptjm-23	123	7	their	their	PRON
bptjm-23	123	8	genetic	genetic	ADJ
bptjm-23	123	9	material	material	NOUN
bptjm-23	123	10	,	,	PUNCT
bptjm-23	123	11	double	double	ADJ
bptjm-23	123	12	stranded	strand	VERB
bptjm-23	123	13	dna	dna	NOUN
bptjm-23	123	14	,	,	PUNCT
bptjm-23	123	15	within	within	ADP
bptjm-23	123	16	this	this	DET
bptjm-23	123	17	characteristic	characteristic	ADJ
bptjm-23	123	18	icosahedral	icosahedral	ADJ
bptjm-23	123	19	chamber	chamber	NOUN
bptjm-23	123	20	.	.	PUNCT
bptjm-23	124	1	adenoviruses	adenovirus	NOUN
bptjm-23	124	2	account	account	VERB
bptjm-23	124	3	for	for	ADP
bptjm-23	124	4	several	several	ADJ
bptjm-23	124	5	acute	acute	ADJ
bptjm-23	124	6	respiratory	respiratory	ADJ
bptjm-23	124	7	illnesses	illness	NOUN
bptjm-23	124	8	and	and	CCONJ
bptjm-23	124	9	human	human	ADJ
bptjm-23	124	10	adenoviruses	adenovirus	NOUN
bptjm-23	124	11	(	(	PUNCT
bptjm-23	124	12	hadvs	hadvs	ADJ
bptjm-23	124	13	)	)	PUNCT
bptjm-23	124	14	have	have	VERB
bptjm-23	124	15	a	a	DET
bptjm-23	124	16	wide	wide	ADJ
bptjm-23	124	17	range	range	NOUN
bptjm-23	124	18	of	of	ADP
bptjm-23	124	19	categorized	categorize	VERB
bptjm-23	124	20	species	specie	NOUN
bptjm-23	124	21	based	base	VERB
bptjm-23	124	22	on	on	ADP
bptjm-23	124	23	key	key	ADJ
bptjm-23	124	24	characteristics	characteristic	NOUN
bptjm-23	124	25	that	that	DET
bptjm-23	124	26	number	number	NOUN
bptjm-23	124	27	over	over	ADP
bptjm-23	124	28	80	80	NUM
bptjm-23	124	29	types35	types35	NOUN
bptjm-23	124	30	.	.	PUNCT
bptjm-23	125	1	work	work	NOUN
bptjm-23	125	2	in	in	ADP
bptjm-23	125	3	gene	gene	NOUN
bptjm-23	125	4	therapy	therapy	NOUN
bptjm-23	125	5	for	for	ADP
bptjm-23	125	6	copd	copd	PROPN
bptjm-23	125	7	stems	stem	VERB
bptjm-23	125	8	from	from	ADP
bptjm-23	125	9	hadvs	hadvs	ADJ
bptjm-23	125	10	’	'	PUNCT
bptjm-23	125	11	versatile	versatile	ADJ
bptjm-23	125	12	tissue	tissue	NOUN
bptjm-23	125	13	tropism	tropism	NOUN
bptjm-23	125	14	and	and	CCONJ
bptjm-23	125	15	prevalence	prevalence	NOUN
bptjm-23	125	16	in	in	ADP
bptjm-23	125	17	lung	lung	NOUN
bptjm-23	125	18	-	-	PUNCT
bptjm-23	125	19	related	relate	VERB
bptjm-23	125	20	diseases	disease	NOUN
bptjm-23	125	21	and	and	CCONJ
bptjm-23	125	22	replication36	replication36	NOUN
bptjm-23	125	23	.	.	PUNCT
bptjm-23	126	1	imaging	imaging	NOUN
bptjm-23	126	2	techniques	technique	NOUN
bptjm-23	126	3	berkeley	berkeley	PROPN
bptjm-23	126	4	pharma	pharma	PROPN
bptjm-23	126	5	tech	tech	NOUN
bptjm-23	126	6	journal	journal	NOUN
bptjm-23	126	7	of	of	ADP
bptjm-23	126	8	medicine	medicine	NOUN
bptjm-23	126	9	|	|	ADV
bptjm-23	126	10	68	68	NUM
bptjm-23	126	11	have	have	AUX
bptjm-23	126	12	revealed	reveal	VERB
bptjm-23	126	13	signi	signi	ADJ
bptjm-23	126	14	�	�	PROPN
bptjm-23	126	15	cantly	cantly	ADV
bptjm-23	126	16	higher	high	ADJ
bptjm-23	126	17	carrying	carrying	NOUN
bptjm-23	126	18	capacity	capacity	NOUN
bptjm-23	126	19	for	for	ADP
bptjm-23	126	20	genetic	genetic	ADJ
bptjm-23	126	21	material	material	NOUN
bptjm-23	126	22	in	in	ADP
bptjm-23	126	23	adenoviruses	adenovirus	NOUN
bptjm-23	126	24	than	than	ADP
bptjm-23	126	25	alternative	alternative	ADJ
bptjm-23	126	26	viral	viral	ADJ
bptjm-23	126	27	vector	vector	NOUN
bptjm-23	126	28	platforms	platform	NOUN
bptjm-23	126	29	at	at	ADP
bptjm-23	126	30	around	around	ADP
bptjm-23	126	31	36	36	NUM
bptjm-23	126	32	kb	kb	NOUN
bptjm-23	126	33	pairs	pair	NOUN
bptjm-23	126	34	while	while	SCONJ
bptjm-23	126	35	delivering	deliver	VERB
bptjm-23	126	36	roughly	roughly	ADV
bptjm-23	126	37	8	8	NUM
bptjm-23	126	38	kb	kb	PROPN
bptjm-23	126	39	pairs	pair	NOUN
bptjm-23	126	40	.	.	PUNCT
bptjm-23	127	1	a	a	DET
bptjm-23	127	2	capacity	capacity	NOUN
bptjm-23	127	3	that	that	PRON
bptjm-23	127	4	can	can	AUX
bptjm-23	127	5	be	be	AUX
bptjm-23	127	6	increased	increase	VERB
bptjm-23	127	7	using	use	VERB
bptjm-23	127	8	a	a	DET
bptjm-23	127	9	newer	new	ADJ
bptjm-23	127	10	generation	generation	NOUN
bptjm-23	127	11	of	of	ADP
bptjm-23	127	12	helper	helper	NOUN
bptjm-23	127	13	-	-	PUNCT
bptjm-23	127	14	dependent	dependent	ADJ
bptjm-23	127	15	adenoviruses	adenovirus	NOUN
bptjm-23	127	16	(	(	PUNCT
bptjm-23	127	17	hd	hd	NOUN
bptjm-23	127	18	-	-	PUNCT
bptjm-23	127	19	advs	advs	NOUN
bptjm-23	127	20	)	)	PUNCT
bptjm-23	127	21	by	by	ADP
bptjm-23	127	22	deleting	delete	VERB
bptjm-23	127	23	the	the	DET
bptjm-23	127	24	viral	viral	ADJ
bptjm-23	127	25	coding	coding	NOUN
bptjm-23	127	26	sequences1,37	sequences1,37	NOUN
bptjm-23	127	27	-	-	PUNCT
bptjm-23	127	28	38	38	NUM
bptjm-23	127	29	.	.	PUNCT
bptjm-23	128	1	such	such	ADJ
bptjm-23	128	2	delivery	delivery	NOUN
bptjm-23	128	3	methods	method	NOUN
bptjm-23	128	4	have	have	AUX
bptjm-23	128	5	been	be	AUX
bptjm-23	128	6	used	use	VERB
bptjm-23	128	7	in	in	ADP
bptjm-23	128	8	gene	gene	NOUN
bptjm-23	128	9	delivery	delivery	NOUN
bptjm-23	128	10	to	to	ADP
bptjm-23	128	11	pig	pig	NOUN
bptjm-23	128	12	airway	airway	NOUN
bptjm-23	128	13	epithelia	epithelia	PROPN
bptjm-23	128	14	to	to	PART
bptjm-23	128	15	demonstrate	demonstrate	VERB
bptjm-23	128	16	delivery	delivery	NOUN
bptjm-23	128	17	of	of	ADP
bptjm-23	128	18	the	the	DET
bptjm-23	128	19	cftr	cftr	NOUN
bptjm-23	128	20	protein	protein	NOUN
bptjm-23	128	21	in	in	ADP
bptjm-23	128	22	hopes	hope	NOUN
bptjm-23	128	23	to	to	PART
bptjm-23	128	24	reverse	reverse	VERB
bptjm-23	128	25	mucus	mucus	NOUN
bptjm-23	128	26	production	production	NOUN
bptjm-23	128	27	and	and	CCONJ
bptjm-23	128	28	in	in	ADP
bptjm-23	128	29	�	�	PROPN
bptjm-23	128	30	ammation	ammation	NOUN
bptjm-23	128	31	in	in	ADP
bptjm-23	128	32	patients	patient	NOUN
bptjm-23	128	33	with	with	ADP
bptjm-23	128	34	cystic	cystic	ADJ
bptjm-23	128	35	�	�	NOUN
bptjm-23	128	36	brosis	brosis	NOUN
bptjm-23	128	37	and	and	CCONJ
bptjm-23	128	38	associated	associated	ADJ
bptjm-23	128	39	lung	lung	NOUN
bptjm-23	128	40	diseases39	diseases39	NOUN
bptjm-23	128	41	.	.	PUNCT
bptjm-23	129	1	as	as	ADP
bptjm-23	129	2	prominent	prominent	ADJ
bptjm-23	129	3	viruses	virus	NOUN
bptjm-23	129	4	in	in	ADP
bptjm-23	129	5	everyday	everyday	ADJ
bptjm-23	129	6	life	life	NOUN
bptjm-23	129	7	a	a	DET
bptjm-23	129	8	common	common	ADJ
bptjm-23	129	9	phenomena	phenomenon	NOUN
bptjm-23	129	10	observed	observe	VERB
bptjm-23	129	11	in	in	ADP
bptjm-23	129	12	usage	usage	NOUN
bptjm-23	129	13	of	of	ADP
bptjm-23	129	14	advs	advs	NOUN
bptjm-23	129	15	for	for	ADP
bptjm-23	129	16	clinical	clinical	ADJ
bptjm-23	129	17	trials	trial	NOUN
bptjm-23	129	18	is	be	AUX
bptjm-23	129	19	pre	pre	ADJ
bptjm-23	129	20	-	-	ADJ
bptjm-23	129	21	existing	exist	VERB
bptjm-23	129	22	immunity	immunity	NOUN
bptjm-23	129	23	40	40	NUM
bptjm-23	129	24	which	which	PRON
bptjm-23	129	25	presents	present	VERB
bptjm-23	129	26	the	the	DET
bptjm-23	129	27	need	need	NOUN
bptjm-23	129	28	for	for	ADP
bptjm-23	129	29	research	research	NOUN
bptjm-23	129	30	of	of	ADP
bptjm-23	129	31	multiple	multiple	ADJ
bptjm-23	129	32	hadv	hadv	NOUN
bptjm-23	129	33	serotypes	serotype	NOUN
bptjm-23	129	34	to	to	PART
bptjm-23	129	35	allow	allow	VERB
bptjm-23	129	36	for	for	ADP
bptjm-23	129	37	versatility	versatility	NOUN
bptjm-23	129	38	in	in	ADP
bptjm-23	129	39	practical	practical	ADJ
bptjm-23	129	40	usage	usage	NOUN
bptjm-23	129	41	as	as	ADP
bptjm-23	129	42	gene	gene	NOUN
bptjm-23	129	43	vectors	vector	NOUN
bptjm-23	129	44	.	.	PUNCT
bptjm-23	130	1	adv	adv	PROPN
bptjm-23	130	2	types	type	NOUN
bptjm-23	130	3	that	that	PRON
bptjm-23	130	4	rely	rely	VERB
bptjm-23	130	5	on	on	ADP
bptjm-23	130	6	a	a	DET
bptjm-23	130	7	singular	singular	ADJ
bptjm-23	130	8	method	method	NOUN
bptjm-23	130	9	of	of	ADP
bptjm-23	130	10	cell	cell	NOUN
bptjm-23	130	11	entry	entry	NOUN
bptjm-23	130	12	have	have	AUX
bptjm-23	130	13	limited	limit	VERB
bptjm-23	130	14	access	access	NOUN
bptjm-23	130	15	points	point	NOUN
bptjm-23	130	16	and	and	CCONJ
bptjm-23	130	17	see	see	VERB
bptjm-23	130	18	more	more	ADJ
bptjm-23	130	19	pre	pre	ADJ
bptjm-23	130	20	-	-	ADJ
bptjm-23	130	21	existing	exist	VERB
bptjm-23	130	22	immunity	immunity	NOUN
bptjm-23	130	23	.	.	PUNCT
bptjm-23	131	1	as	as	SCONJ
bptjm-23	131	2	previously	previously	ADV
bptjm-23	131	3	mentioned	mention	VERB
bptjm-23	131	4	,	,	PUNCT
bptjm-23	131	5	hadvs	hadvs	ADJ
bptjm-23	131	6	types	type	NOUN
bptjm-23	131	7	are	be	AUX
bptjm-23	131	8	plentiful	plentiful	ADJ
bptjm-23	131	9	and	and	CCONJ
bptjm-23	131	10	subcategorized	subcategorize	VERB
bptjm-23	131	11	into	into	ADP
bptjm-23	131	12	7	7	NUM
bptjm-23	131	13	grand	grand	ADJ
bptjm-23	131	14	species	specie	NOUN
bptjm-23	131	15	a	a	DET
bptjm-23	131	16	-	-	PUNCT
bptjm-23	131	17	g	g	NOUN
bptjm-23	131	18	,	,	PUNCT
bptjm-23	131	19	the	the	DET
bptjm-23	131	20	majority	majority	NOUN
bptjm-23	131	21	of	of	ADP
bptjm-23	131	22	which	which	PRON
bptjm-23	131	23	belong	belong	VERB
bptjm-23	131	24	to	to	ADP
bptjm-23	131	25	the	the	DET
bptjm-23	131	26	hadv	hadv	NOUN
bptjm-23	131	27	-	-	PUNCT
bptjm-23	131	28	d	d	NOUN
bptjm-23	131	29	family40	family40	NOUN
bptjm-23	131	30	.	.	PUNCT
bptjm-23	132	1	hadv	hadv	PROPN
bptjm-23	132	2	-	-	PUNCT
bptjm-23	132	3	d	d	PROPN
bptjm-23	132	4	type	type	NOUN
bptjm-23	132	5	49	49	NUM
bptjm-23	132	6	is	be	AUX
bptjm-23	132	7	one	one	NUM
bptjm-23	132	8	of	of	ADP
bptjm-23	132	9	many	many	ADJ
bptjm-23	132	10	hadv	hadv	NOUN
bptjm-23	132	11	types	type	NOUN
bptjm-23	132	12	that	that	PRON
bptjm-23	132	13	utilize	utilize	VERB
bptjm-23	132	14	varying	vary	VERB
bptjm-23	132	15	surface	surface	NOUN
bptjm-23	132	16	molecules	molecule	NOUN
bptjm-23	132	17	to	to	PART
bptjm-23	132	18	enter	enter	VERB
bptjm-23	132	19	the	the	DET
bptjm-23	132	20	cell	cell	NOUN
bptjm-23	132	21	and	and	CCONJ
bptjm-23	132	22	as	as	ADP
bptjm-23	132	23	a	a	DET
bptjm-23	132	24	result	result	NOUN
bptjm-23	132	25	is	be	AUX
bptjm-23	132	26	a	a	DET
bptjm-23	132	27	prime	prime	ADJ
bptjm-23	132	28	candidate	candidate	NOUN
bptjm-23	132	29	for	for	ADP
bptjm-23	132	30	research	research	NOUN
bptjm-23	132	31	in	in	ADP
bptjm-23	132	32	adv	adv	PROPN
bptjm-23	132	33	vectors	vector	NOUN
bptjm-23	132	34	to	to	PART
bptjm-23	132	35	solve	solve	VERB
bptjm-23	132	36	this	this	DET
bptjm-23	132	37	issue	issue	NOUN
bptjm-23	132	38	of	of	ADP
bptjm-23	132	39	immunity	immunity	NOUN
bptjm-23	132	40	.	.	PUNCT
bptjm-23	133	1	the	the	DET
bptjm-23	133	2	viability	viability	NOUN
bptjm-23	133	3	of	of	ADP
bptjm-23	133	4	hadv	hadv	NOUN
bptjm-23	133	5	-	-	PUNCT
bptjm-23	133	6	d49	d49	NOUN
bptjm-23	133	7	is	be	AUX
bptjm-23	133	8	compounded	compound	VERB
bptjm-23	133	9	by	by	ADP
bptjm-23	133	10	its	its	PRON
bptjm-23	133	11	observed	observed	ADJ
bptjm-23	133	12	transduction	transduction	NOUN
bptjm-23	133	13	in	in	ADP
bptjm-23	133	14	lung	lung	NOUN
bptjm-23	133	15	and	and	CCONJ
bptjm-23	133	16	spleen	spleen	NOUN
bptjm-23	133	17	tissues	tissue	NOUN
bptjm-23	133	18	while	while	SCONJ
bptjm-23	133	19	showing	show	VERB
bptjm-23	133	20	reduced	reduced	ADJ
bptjm-23	133	21	targeting	target	VERB
bptjm-23	133	22	in	in	ADP
bptjm-23	133	23	liver	liver	NOUN
bptjm-23	133	24	and	and	CCONJ
bptjm-23	133	25	other	other	ADJ
bptjm-23	133	26	less	less	ADV
bptjm-23	133	27	desirable	desirable	ADJ
bptjm-23	133	28	tissues	tissue	NOUN
bptjm-23	133	29	when	when	SCONJ
bptjm-23	133	30	looking	look	VERB
bptjm-23	133	31	at	at	ADP
bptjm-23	133	32	in	in	ADP
bptjm-23	133	33	vivo	vivo	NOUN
bptjm-23	133	34	biodistribution41	biodistribution41	NOUN
bptjm-23	133	35	.	.	PUNCT
bptjm-23	134	1	immune	immune	ADJ
bptjm-23	134	2	response	response	NOUN
bptjm-23	134	3	has	have	AUX
bptjm-23	134	4	also	also	ADV
bptjm-23	134	5	been	be	AUX
bptjm-23	134	6	mitigated	mitigate	VERB
bptjm-23	134	7	by	by	ADP
bptjm-23	134	8	using	use	VERB
bptjm-23	134	9	hd	hd	NOUN
bptjm-23	134	10	-	-	PUNCT
bptjm-23	134	11	adv	adv	NOUN
bptjm-23	134	12	vectors	vector	NOUN
bptjm-23	134	13	as	as	SCONJ
bptjm-23	134	14	their	their	PRON
bptjm-23	134	15	stripped	strip	VERB
bptjm-23	134	16	down	down	ADP
bptjm-23	134	17	genome	genome	NOUN
bptjm-23	134	18	removes	remove	VERB
bptjm-23	134	19	key	key	ADJ
bptjm-23	134	20	markers	marker	NOUN
bptjm-23	134	21	for	for	ADP
bptjm-23	134	22	the	the	DET
bptjm-23	134	23	immune	immune	ADJ
bptjm-23	134	24	system	system	NOUN
bptjm-23	134	25	to	to	PART
bptjm-23	134	26	identify	identify	VERB
bptjm-23	134	27	and	and	CCONJ
bptjm-23	134	28	target	target	VERB
bptjm-23	134	29	.	.	PUNCT
bptjm-23	135	1	airway	airway	NOUN
bptjm-23	135	2	basal	basal	VERB
bptjm-23	135	3	cells	cell	NOUN
bptjm-23	135	4	of	of	ADP
bptjm-23	135	5	mice	mouse	NOUN
bptjm-23	135	6	and	and	CCONJ
bptjm-23	135	7	pigs	pig	NOUN
bptjm-23	135	8	have	have	AUX
bptjm-23	135	9	been	be	AUX
bptjm-23	135	10	targeted	target	VERB
bptjm-23	135	11	successfully	successfully	ADV
bptjm-23	135	12	using	use	VERB
bptjm-23	135	13	these	these	DET
bptjm-23	135	14	hdadvs	hdadvs	ADJ
bptjm-23	135	15	following	follow	VERB
bptjm-23	135	16	intranasal	intranasal	NOUN
bptjm-23	135	17	delivery42,43	delivery42,43	ADJ
bptjm-23	135	18	.	.	PUNCT
bptjm-23	136	1	limiting	limit	VERB
bptjm-23	136	2	immune	immune	ADJ
bptjm-23	136	3	response	response	NOUN
bptjm-23	136	4	while	while	SCONJ
bptjm-23	136	5	maintaining	maintain	VERB
bptjm-23	136	6	a	a	DET
bptjm-23	136	7	focus	focus	NOUN
bptjm-23	136	8	on	on	ADP
bptjm-23	136	9	the	the	DET
bptjm-23	136	10	e	e	PROPN
bptjm-23	136	11	�	�	PROPN
bptjm-23	136	12	cacy	cacy	NOUN
bptjm-23	136	13	of	of	ADP
bptjm-23	136	14	adv	adv	PROPN
bptjm-23	136	15	based	base	VERB
bptjm-23	136	16	gene	gene	NOUN
bptjm-23	136	17	therapy	therapy	NOUN
bptjm-23	136	18	is	be	AUX
bptjm-23	136	19	the	the	DET
bptjm-23	136	20	current	current	ADJ
bptjm-23	136	21	objective	objective	NOUN
bptjm-23	136	22	that	that	PRON
bptjm-23	136	23	needs	need	VERB
bptjm-23	136	24	�	�	NOUN
bptjm-23	136	25	ne	ne	NOUN
bptjm-23	136	26	tuning	tune	VERB
bptjm-23	136	27	in	in	ADP
bptjm-23	136	28	research	research	NOUN
bptjm-23	136	29	for	for	ADP
bptjm-23	136	30	adv	adv	PROPN
bptjm-23	136	31	vectors	vector	NOUN
bptjm-23	136	32	to	to	PART
bptjm-23	136	33	obtain	obtain	VERB
bptjm-23	136	34	signi	signi	ADJ
bptjm-23	136	35	�	�	NOUN
bptjm-23	136	36	cant	cant	VERB
bptjm-23	136	37	clinical	clinical	ADJ
bptjm-23	136	38	success	success	NOUN
bptjm-23	136	39	.	.	PUNCT
bptjm-23	137	1	adeno	adeno	NOUN
bptjm-23	137	2	-	-	PUNCT
bptjm-23	137	3	associated	associate	VERB
bptjm-23	137	4	viruses	virus	NOUN
bptjm-23	137	5	to	to	PART
bptjm-23	137	6	build	build	VERB
bptjm-23	137	7	upon	upon	SCONJ
bptjm-23	137	8	the	the	DET
bptjm-23	137	9	problem	problem	NOUN
bptjm-23	137	10	of	of	ADP
bptjm-23	137	11	immune	immune	ADJ
bptjm-23	137	12	response	response	NOUN
bptjm-23	137	13	many	many	ADJ
bptjm-23	137	14	relatively	relatively	ADV
bptjm-23	137	15	distant	distant	ADJ
bptjm-23	137	16	derivatives	derivative	NOUN
bptjm-23	137	17	of	of	ADP
bptjm-23	137	18	adv	adv	PROPN
bptjm-23	137	19	virus	virus	NOUN
bptjm-23	137	20	vectors	vector	NOUN
bptjm-23	137	21	have	have	AUX
bptjm-23	137	22	been	be	AUX
bptjm-23	137	23	created	create	VERB
bptjm-23	137	24	known	know	VERB
bptjm-23	137	25	as	as	ADP
bptjm-23	137	26	adeno	adeno	NOUN
bptjm-23	137	27	-	-	PUNCT
bptjm-23	137	28	associated	associate	VERB
bptjm-23	137	29	virus	virus	NOUN
bptjm-23	137	30	(	(	PUNCT
bptjm-23	137	31	aav	aav	NOUN
bptjm-23	137	32	)	)	PUNCT
bptjm-23	137	33	vectors	vector	NOUN
bptjm-23	137	34	.	.	PUNCT
bptjm-23	138	1	these	these	PRON
bptjm-23	138	2	have	have	VERB
bptjm-23	138	3	more	more	ADV
bptjm-23	138	4	desirable	desirable	ADJ
bptjm-23	138	5	immunogenicity	immunogenicity	NOUN
bptjm-23	138	6	.	.	PUNCT
bptjm-23	139	1	they	they	PRON
bptjm-23	139	2	evoke	evoke	VERB
bptjm-23	139	3	a	a	DET
bptjm-23	139	4	weak	weak	ADJ
bptjm-23	139	5	in	in	ADP
bptjm-23	139	6	�	�	NOUN
bptjm-23	139	7	ammatory	ammatory	ADJ
bptjm-23	139	8	response	response	NOUN
bptjm-23	139	9	compared	compare	VERB
bptjm-23	139	10	to	to	ADP
bptjm-23	139	11	berkeley	berkeley	PROPN
bptjm-23	139	12	pharma	pharma	PROPN
bptjm-23	139	13	tech	tech	NOUN
bptjm-23	139	14	journal	journal	NOUN
bptjm-23	139	15	of	of	ADP
bptjm-23	139	16	medicine	medicine	NOUN
bptjm-23	139	17	|	|	ADV
bptjm-23	139	18	69	69	NUM
bptjm-23	139	19	adv	adv	PROPN
bptjm-23	139	20	vectors	vector	NOUN
bptjm-23	139	21	by	by	ADP
bptjm-23	139	22	lacking	lack	VERB
bptjm-23	139	23	a	a	DET
bptjm-23	139	24	staple	staple	ADJ
bptjm-23	139	25	viral	viral	ADJ
bptjm-23	139	26	coding	code	VERB
bptjm-23	139	27	sequence	sequence	NOUN
bptjm-23	139	28	and	and	CCONJ
bptjm-23	139	29	contain	contain	VERB
bptjm-23	139	30	a	a	DET
bptjm-23	139	31	linear	linear	ADJ
bptjm-23	139	32	single	single	ADV
bptjm-23	139	33	-	-	PUNCT
bptjm-23	139	34	stranded	strand	VERB
bptjm-23	139	35	dna	dna	NOUN
bptjm-23	139	36	.	.	PUNCT
bptjm-23	140	1	behavioral	behavioral	PROPN
bptjm-23	140	2	di	di	PROPN
bptjm-23	140	3	�	�	PROPN
bptjm-23	140	4	erences	erence	NOUN
bptjm-23	140	5	in	in	ADP
bptjm-23	140	6	host	host	NOUN
bptjm-23	140	7	integration	integration	NOUN
bptjm-23	140	8	led	lead	VERB
bptjm-23	140	9	to	to	ADP
bptjm-23	140	10	its	its	PRON
bptjm-23	140	11	prevalence	prevalence	NOUN
bptjm-23	140	12	in	in	ADP
bptjm-23	140	13	research	research	NOUN
bptjm-23	140	14	as	as	ADP
bptjm-23	140	15	an	an	DET
bptjm-23	140	16	option	option	NOUN
bptjm-23	140	17	for	for	ADP
bptjm-23	140	18	gene	gene	NOUN
bptjm-23	140	19	therapy	therapy	NOUN
bptjm-23	140	20	.	.	PUNCT
bptjm-23	141	1	carrying	carry	VERB
bptjm-23	141	2	capacity	capacity	NOUN
bptjm-23	141	3	in	in	ADP
bptjm-23	141	4	aav	aav	NOUN
bptjm-23	141	5	vectors	vector	NOUN
bptjm-23	141	6	is	be	AUX
bptjm-23	141	7	limited	limit	VERB
bptjm-23	141	8	in	in	ADP
bptjm-23	141	9	comparison	comparison	NOUN
bptjm-23	141	10	to	to	ADP
bptjm-23	141	11	advs	advs	PROPN
bptjm-23	141	12	at	at	ADP
bptjm-23	141	13	typically	typically	ADV
bptjm-23	141	14	less	less	ADJ
bptjm-23	141	15	than	than	ADP
bptjm-23	141	16	5	5	NUM
bptjm-23	141	17	kb	kb	NOUN
bptjm-23	141	18	though	though	SCONJ
bptjm-23	141	19	reports	report	NOUN
bptjm-23	141	20	have	have	AUX
bptjm-23	141	21	seen	see	VERB
bptjm-23	141	22	up	up	ADP
bptjm-23	141	23	to	to	ADP
bptjm-23	141	24	~9	~9	ADP
bptjm-23	141	25	kb	kb	PROPN
bptjm-23	141	26	of	of	ADP
bptjm-23	141	27	genome	genome	NOUN
bptjm-23	141	28	e	e	NOUN
bptjm-23	141	29	�	�	NOUN
bptjm-23	141	30	ciently	ciently	ADV
bptjm-23	141	31	incorporated	incorporate	VERB
bptjm-23	141	32	into	into	ADP
bptjm-23	141	33	aav	aav	NOUN
bptjm-23	141	34	vectors	vector	NOUN
bptjm-23	141	35	for	for	ADP
bptjm-23	141	36	therapeutics44,45	therapeutics44,45	PROPN
bptjm-23	141	37	.	.	PUNCT
bptjm-23	142	1	increased	increase	VERB
bptjm-23	142	2	packaging	packaging	NOUN
bptjm-23	142	3	capacity	capacity	NOUN
bptjm-23	142	4	typically	typically	ADV
bptjm-23	142	5	comes	come	VERB
bptjm-23	142	6	at	at	ADP
bptjm-23	142	7	a	a	DET
bptjm-23	142	8	cost	cost	NOUN
bptjm-23	142	9	of	of	ADP
bptjm-23	142	10	transduction	transduction	NOUN
bptjm-23	142	11	rate	rate	NOUN
bptjm-23	142	12	and	and	CCONJ
bptjm-23	142	13	overall	overall	ADJ
bptjm-23	142	14	e	e	NOUN
bptjm-23	142	15	�	�	NOUN
bptjm-23	142	16	cacy	cacy	NOUN
bptjm-23	142	17	in	in	ADP
bptjm-23	142	18	aav	aav	NOUN
bptjm-23	142	19	vectors	vector	NOUN
bptjm-23	142	20	though	though	SCONJ
bptjm-23	142	21	research	research	NOUN
bptjm-23	142	22	continues	continue	VERB
bptjm-23	142	23	to	to	PART
bptjm-23	142	24	be	be	AUX
bptjm-23	142	25	done	do	VERB
bptjm-23	142	26	to	to	PART
bptjm-23	142	27	improve	improve	VERB
bptjm-23	142	28	the	the	DET
bptjm-23	142	29	most	most	ADV
bptjm-23	142	30	pressing	pressing	ADJ
bptjm-23	142	31	drawback	drawback	NOUN
bptjm-23	142	32	of	of	ADP
bptjm-23	142	33	the	the	DET
bptjm-23	142	34	delivery	delivery	NOUN
bptjm-23	142	35	method	method	NOUN
bptjm-23	142	36	.	.	PUNCT
bptjm-23	143	1	researchers	researcher	NOUN
bptjm-23	143	2	at	at	ADP
bptjm-23	143	3	stanford	stanford	PROPN
bptjm-23	143	4	have	have	AUX
bptjm-23	143	5	altered	alter	VERB
bptjm-23	143	6	charges	charge	NOUN
bptjm-23	143	7	in	in	ADP
bptjm-23	143	8	the	the	DET
bptjm-23	143	9	lumen	luman	NOUN
bptjm-23	143	10	of	of	ADP
bptjm-23	143	11	aav	aav	NOUN
bptjm-23	143	12	variants	variant	NOUN
bptjm-23	143	13	known	know	VERB
bptjm-23	143	14	as	as	ADP
bptjm-23	143	15	aavdj	aavdj	NOUN
bptjm-23	143	16	to	to	PART
bptjm-23	143	17	transduce	transduce	VERB
bptjm-23	143	18	cells	cell	NOUN
bptjm-23	143	19	derived	derive	VERB
bptjm-23	143	20	from	from	ADP
bptjm-23	143	21	human	human	ADJ
bptjm-23	143	22	kidneys	kidney	NOUN
bptjm-23	143	23	better	well	ADJ
bptjm-23	143	24	than	than	ADP
bptjm-23	143	25	wildtypes	wildtype	NOUN
bptjm-23	143	26	when	when	SCONJ
bptjm-23	143	27	packed	pack	VERB
bptjm-23	143	28	at	at	ADP
bptjm-23	143	29	a	a	DET
bptjm-23	143	30	higher	high	ADJ
bptjm-23	143	31	rate	rate	NOUN
bptjm-23	143	32	of	of	ADP
bptjm-23	143	33	up	up	ADP
bptjm-23	143	34	to	to	PART
bptjm-23	143	35	6.2	6.2	NUM
bptjm-23	143	36	kb46	kb46	NOUN
bptjm-23	143	37	.	.	PUNCT
bptjm-23	144	1	more	more	ADV
bptjm-23	144	2	akin	akin	ADJ
bptjm-23	144	3	to	to	ADP
bptjm-23	144	4	lung	lung	NOUN
bptjm-23	144	5	therapies	therapy	NOUN
bptjm-23	144	6	for	for	ADP
bptjm-23	144	7	copd	copd	NOUN
bptjm-23	144	8	,	,	PUNCT
bptjm-23	144	9	viral	viral	ADJ
bptjm-23	144	10	/	/	SYM
bptjm-23	144	11	aav	aav	NOUN
bptjm-23	144	12	chimeric	chimeric	ADJ
bptjm-23	144	13	gene	gene	NOUN
bptjm-23	144	14	therapy	therapy	NOUN
bptjm-23	144	15	has	have	AUX
bptjm-23	144	16	seen	see	VERB
bptjm-23	144	17	signi	signi	PROPN
bptjm-23	144	18	�	�	NOUN
bptjm-23	144	19	cant	cant	VERB
bptjm-23	144	20	research	research	NOUN
bptjm-23	144	21	in	in	ADP
bptjm-23	144	22	navigating	navigate	VERB
bptjm-23	144	23	human	human	ADJ
bptjm-23	144	24	epithelial	epithelial	ADJ
bptjm-23	144	25	cells	cell	NOUN
bptjm-23	144	26	.	.	PUNCT
bptjm-23	145	1	chimeric	chimeric	ADJ
bptjm-23	145	2	viral	viral	ADJ
bptjm-23	145	3	vectors	vector	NOUN
bptjm-23	145	4	look	look	VERB
bptjm-23	145	5	at	at	ADP
bptjm-23	145	6	combinations	combination	NOUN
bptjm-23	145	7	of	of	ADP
bptjm-23	145	8	multiple	multiple	ADJ
bptjm-23	145	9	vector	vector	NOUN
bptjm-23	145	10	methods	method	NOUN
bptjm-23	145	11	in	in	ADP
bptjm-23	145	12	hopes	hope	NOUN
bptjm-23	145	13	to	to	PART
bptjm-23	145	14	take	take	VERB
bptjm-23	145	15	advantage	advantage	NOUN
bptjm-23	145	16	of	of	ADP
bptjm-23	145	17	favorable	favorable	ADJ
bptjm-23	145	18	characteristics	characteristic	NOUN
bptjm-23	145	19	in	in	ADP
bptjm-23	145	20	each	each	DET
bptjm-23	145	21	and	and	CCONJ
bptjm-23	145	22	pose	pose	VERB
bptjm-23	145	23	grounds	ground	NOUN
bptjm-23	145	24	for	for	ADP
bptjm-23	145	25	signi	signi	ADJ
bptjm-23	145	26	�	�	NOUN
bptjm-23	145	27	cant	cant	NOUN
bptjm-23	145	28	advancement	advancement	NOUN
bptjm-23	145	29	in	in	ADP
bptjm-23	145	30	gene	gene	NOUN
bptjm-23	145	31	therapy	therapy	NOUN
bptjm-23	145	32	for	for	ADP
bptjm-23	145	33	respiratory	respiratory	ADJ
bptjm-23	145	34	diseases	disease	NOUN
bptjm-23	145	35	given	give	VERB
bptjm-23	145	36	local	local	ADJ
bptjm-23	145	37	cell	cell	NOUN
bptjm-23	145	38	selectivity	selectivity	NOUN
bptjm-23	145	39	.	.	PUNCT
bptjm-23	146	1	a	a	DET
bptjm-23	146	2	type	type	NOUN
bptjm-23	146	3	of	of	ADP
bptjm-23	146	4	chimera	chimera	NOUN
bptjm-23	146	5	vector	vector	NOUN
bptjm-23	146	6	packaging	packaging	NOUN
bptjm-23	146	7	plasmids	plasmid	NOUN
bptjm-23	146	8	using	use	VERB
bptjm-23	146	9	aav	aav	NOUN
bptjm-23	146	10	and	and	CCONJ
bptjm-23	146	11	human	human	ADJ
bptjm-23	146	12	bocaviruses	bocaviruse	NOUN
bptjm-23	146	13	(	(	PUNCT
bptjm-23	146	14	hbov	hbov	PROPN
bptjm-23	146	15	)	)	PUNCT
bptjm-23	146	16	been	be	AUX
bptjm-23	146	17	shown	show	VERB
bptjm-23	146	18	to	to	PART
bptjm-23	146	19	work	work	VERB
bptjm-23	146	20	well	well	ADV
bptjm-23	146	21	in	in	ADP
bptjm-23	146	22	tandem	tandem	NOUN
bptjm-23	146	23	with	with	ADP
bptjm-23	146	24	human	human	ADJ
bptjm-23	146	25	airway	airway	NOUN
bptjm-23	146	26	epithelia	epithelia	PROPN
bptjm-23	146	27	,	,	PUNCT
bptjm-23	146	28	primary	primary	ADJ
bptjm-23	146	29	human	human	ADJ
bptjm-23	146	30	hepatocytes	hepatocyte	NOUN
bptjm-23	146	31	,	,	PUNCT
bptjm-23	146	32	skeletal	skeletal	ADJ
bptjm-23	146	33	muscle	muscle	NOUN
bptjm-23	146	34	cells	cell	NOUN
bptjm-23	146	35	,	,	PUNCT
bptjm-23	146	36	and	and	CCONJ
bptjm-23	146	37	t	t	NOUN
bptjm-23	146	38	cells	cell	NOUN
bptjm-23	146	39	;	;	PUNCT
bptjm-23	146	40	in	in	ADP
bptjm-23	146	41	addition	addition	NOUN
bptjm-23	146	42	to	to	ADP
bptjm-23	146	43	good	good	ADJ
bptjm-23	146	44	performance	performance	NOUN
bptjm-23	146	45	in	in	ADP
bptjm-23	146	46	extensive	extensive	ADJ
bptjm-23	146	47	studies	study	NOUN
bptjm-23	146	48	in	in	ADP
bptjm-23	146	49	ferret	ferret	NOUN
bptjm-23	146	50	airway	airway	NOUN
bptjm-23	146	51	models	model	NOUN
bptjm-23	146	52	more	more	ADJ
bptjm-23	146	53	recently47,48	recently47,48	NOUN
bptjm-23	146	54	.	.	PUNCT
bptjm-23	147	1	these	these	DET
bptjm-23	147	2	aav	aav	PROPN
bptjm-23	147	3	/	/	SYM
bptjm-23	147	4	hbov	hbov	PROPN
bptjm-23	147	5	combination	combination	NOUN
bptjm-23	147	6	vectors	vector	NOUN
bptjm-23	147	7	o	o	NOUN
bptjm-23	147	8	�	�	PROPN
bptjm-23	147	9	er	er	INTJ
bptjm-23	147	10	a	a	DET
bptjm-23	147	11	novel	novel	ADJ
bptjm-23	147	12	approach	approach	NOUN
bptjm-23	147	13	to	to	ADP
bptjm-23	147	14	creating	create	VERB
bptjm-23	147	15	vectors	vector	NOUN
bptjm-23	147	16	for	for	ADP
bptjm-23	147	17	gene	gene	NOUN
bptjm-23	147	18	therapy	therapy	NOUN
bptjm-23	147	19	in	in	ADP
bptjm-23	147	20	treatment	treatment	NOUN
bptjm-23	147	21	of	of	ADP
bptjm-23	147	22	copd	copd	NOUN
bptjm-23	147	23	.	.	PUNCT
bptjm-23	148	1	potential	potential	ADJ
bptjm-23	148	2	treatment	treatment	NOUN
bptjm-23	148	3	there	there	PRON
bptjm-23	148	4	are	be	VERB
bptjm-23	148	5	many	many	ADJ
bptjm-23	148	6	limitations	limitation	NOUN
bptjm-23	148	7	to	to	ADP
bptjm-23	148	8	modern	modern	ADJ
bptjm-23	148	9	gene	gene	NOUN
bptjm-23	148	10	therapies	therapy	NOUN
bptjm-23	148	11	used	use	VERB
bptjm-23	148	12	today	today	NOUN
bptjm-23	148	13	caused	cause	VERB
bptjm-23	148	14	by	by	ADP
bptjm-23	148	15	many	many	ADJ
bptjm-23	148	16	biological	biological	ADJ
bptjm-23	148	17	barriers	barrier	NOUN
bptjm-23	148	18	.	.	PUNCT
bptjm-23	149	1	[	[	X
bptjm-23	149	2	jg1	jg1	X
bptjm-23	149	3	]	]	X
bptjm-23	149	4	most	most	ADJ
bptjm-23	149	5	lung	lung	NOUN
bptjm-23	149	6	-	-	PUNCT
bptjm-23	149	7	related	relate	VERB
bptjm-23	149	8	therapies	therapy	NOUN
bptjm-23	149	9	must	must	AUX
bptjm-23	149	10	pass	pass	VERB
bptjm-23	149	11	through	through	ADP
bptjm-23	149	12	multiple	multiple	ADJ
bptjm-23	149	13	barriers	barrier	NOUN
bptjm-23	149	14	such	such	ADJ
bptjm-23	149	15	as	as	ADP
bptjm-23	149	16	the	the	DET
bptjm-23	149	17	mucus	mucus	NOUN
bptjm-23	149	18	,	,	PUNCT
bptjm-23	149	19	pulmonary	pulmonary	ADJ
bptjm-23	149	20	surfactant	surfactant	NOUN
bptjm-23	149	21	,	,	PUNCT
bptjm-23	149	22	and	and	CCONJ
bptjm-23	149	23	local	local	ADJ
bptjm-23	149	24	in	in	ADP
bptjm-23	149	25	�	�	PROPN
bptjm-23	149	26	ammation24	ammation24	PROPN
bptjm-23	149	27	.	.	PUNCT
bptjm-23	150	1	this	this	PRON
bptjm-23	150	2	could	could	AUX
bptjm-23	150	3	cause	cause	VERB
bptjm-23	150	4	a	a	DET
bptjm-23	150	5	problem	problem	NOUN
bptjm-23	150	6	since	since	SCONJ
bptjm-23	150	7	patients	patient	NOUN
bptjm-23	150	8	with	with	ADP
bptjm-23	150	9	diseases	disease	NOUN
bptjm-23	150	10	such	such	ADJ
bptjm-23	150	11	as	as	ADP
bptjm-23	150	12	asthma	asthma	NOUN
bptjm-23	150	13	and	and	CCONJ
bptjm-23	150	14	cystic	cystic	ADJ
bptjm-23	150	15	�	�	NOUN
bptjm-23	150	16	brosis	brosis	NOUN
bptjm-23	150	17	could	could	AUX
bptjm-23	150	18	also	also	ADV
bptjm-23	150	19	cause	cause	VERB
bptjm-23	150	20	a	a	DET
bptjm-23	150	21	biological	biological	ADJ
bptjm-23	150	22	barrier	barrier	NOUN
bptjm-23	150	23	due	due	ADP
bptjm-23	150	24	to	to	ADP
bptjm-23	150	25	the	the	DET
bptjm-23	150	26	airway	airway	NOUN
bptjm-23	150	27	mucus	mucus	NOUN
bptjm-23	150	28	hypersecretion	hypersecretion	NOUN
bptjm-23	150	29	,	,	PUNCT
bptjm-23	150	30	which	which	PRON
bptjm-23	150	31	also	also	ADV
bptjm-23	150	32	plays	play	VERB
bptjm-23	150	33	a	a	DET
bptjm-23	150	34	role	role	NOUN
bptjm-23	150	35	in	in	ADP
bptjm-23	150	36	copd	copd	NOUN
bptjm-23	150	37	,	,	PUNCT
bptjm-23	150	38	since	since	SCONJ
bptjm-23	150	39	around	around	ADV
bptjm-23	150	40	50	50	NUM
bptjm-23	150	41	%	%	NOUN
bptjm-23	150	42	of	of	ADP
bptjm-23	150	43	copd	copd	NOUN
bptjm-23	150	44	patients	patient	NOUN
bptjm-23	150	45	have	have	VERB
bptjm-23	150	46	airway	airway	NOUN
bptjm-23	150	47	mucus	mucus	PROPN
bptjm-23	150	48	hypersecretion25	hypersecretion25	PROPN
bptjm-23	150	49	.	.	PUNCT
bptjm-23	151	1	berkeley	berkeley	PROPN
bptjm-23	151	2	pharma	pharma	PROPN
bptjm-23	151	3	tech	tech	PROPN
bptjm-23	151	4	journal	journal	NOUN
bptjm-23	151	5	of	of	ADP
bptjm-23	151	6	medicine	medicine	NOUN
bptjm-23	151	7	|	|	ADV
bptjm-23	151	8	70	70	NUM
bptjm-23	151	9	another	another	DET
bptjm-23	151	10	limitation	limitation	NOUN
bptjm-23	151	11	is	be	AUX
bptjm-23	151	12	when	when	SCONJ
bptjm-23	151	13	targeting	target	VERB
bptjm-23	151	14	jg3	jg3	PROPN
bptjm-23	151	15	cells	cell	NOUN
bptjm-23	151	16	other	other	ADJ
bptjm-23	151	17	than	than	ADP
bptjm-23	151	18	the	the	DET
bptjm-23	151	19	epithelium	epithelium	NOUN
bptjm-23	151	20	cells	cell	NOUN
bptjm-23	151	21	will	will	AUX
bptjm-23	151	22	cause	cause	VERB
bptjm-23	151	23	the	the	DET
bptjm-23	151	24	epithelium	epithelium	NOUN
bptjm-23	151	25	cells	cell	NOUN
bptjm-23	151	26	itself	itself	PRON
bptjm-23	151	27	to	to	PART
bptjm-23	151	28	become	become	VERB
bptjm-23	151	29	a	a	DET
bptjm-23	151	30	major	major	ADJ
bptjm-23	151	31	barrier24	barrier24	NOUN
bptjm-23	151	32	.	.	PUNCT
bptjm-23	152	1	although	although	SCONJ
bptjm-23	152	2	there	there	PRON
bptjm-23	152	3	are	be	VERB
bptjm-23	152	4	several	several	ADJ
bptjm-23	152	5	limitations	limitation	NOUN
bptjm-23	152	6	to	to	ADP
bptjm-23	152	7	current	current	ADJ
bptjm-23	152	8	gene	gene	NOUN
bptjm-23	152	9	therapies	therapy	NOUN
bptjm-23	152	10	,	,	PUNCT
bptjm-23	152	11	there	there	PRON
bptjm-23	152	12	are	be	VERB
bptjm-23	152	13	other	other	ADJ
bptjm-23	152	14	alternatives	alternative	NOUN
bptjm-23	152	15	to	to	PART
bptjm-23	152	16	target	target	VERB
bptjm-23	152	17	cells	cell	NOUN
bptjm-23	152	18	that	that	PRON
bptjm-23	152	19	could	could	AUX
bptjm-23	152	20	be	be	AUX
bptjm-23	152	21	considered	consider	VERB
bptjm-23	152	22	in	in	ADP
bptjm-23	152	23	treatments	treatment	NOUN
bptjm-23	152	24	.	.	PUNCT
bptjm-23	153	1	for	for	ADP
bptjm-23	153	2	example	example	NOUN
bptjm-23	153	3	,	,	PUNCT
bptjm-23	153	4	epithelial	epithelial	ADJ
bptjm-23	153	5	cells	cell	NOUN
bptjm-23	153	6	,	,	PUNCT
bptjm-23	153	7	alveolar	alveolar	ADJ
bptjm-23	153	8	cells	cell	NOUN
bptjm-23	153	9	,	,	PUNCT
bptjm-23	153	10	and	and	CCONJ
bptjm-23	153	11	macrophages	macrophage	NOUN
bptjm-23	153	12	all	all	PRON
bptjm-23	153	13	can	can	AUX
bptjm-23	153	14	be	be	AUX
bptjm-23	153	15	accessed	access	VERB
bptjm-23	153	16	through	through	ADP
bptjm-23	153	17	inhalation	inhalation	NOUN
bptjm-23	153	18	of	of	ADP
bptjm-23	153	19	nucleic	nucleic	ADJ
bptjm-23	153	20	acid	acid	NOUN
bptjm-23	153	21	containing	contain	VERB
bptjm-23	153	22	nanoparticles	nanoparticle	NOUN
bptjm-23	153	23	(	(	PUNCT
bptjm-23	153	24	nans)26	nans)26	PROPN
bptjm-23	153	25	.	.	PUNCT
bptjm-23	154	1	this	this	DET
bptjm-23	154	2	method	method	NOUN
bptjm-23	154	3	of	of	ADP
bptjm-23	154	4	treatment	treatment	NOUN
bptjm-23	154	5	helps	help	VERB
bptjm-23	154	6	target	target	VERB
bptjm-23	154	7	the	the	DET
bptjm-23	154	8	lung	lung	NOUN
bptjm-23	154	9	and	and	CCONJ
bptjm-23	154	10	not	not	PART
bptjm-23	154	11	target	target	VERB
bptjm-23	154	12	other	other	ADJ
bptjm-23	154	13	cells	cell	NOUN
bptjm-23	154	14	that	that	PRON
bptjm-23	154	15	could	could	AUX
bptjm-23	154	16	cause	cause	VERB
bptjm-23	154	17	biological	biological	ADJ
bptjm-23	154	18	barriers	barrier	NOUN
bptjm-23	154	19	.	.	PUNCT
bptjm-23	155	1	although	although	SCONJ
bptjm-23	155	2	inhalation	inhalation	NOUN
bptjm-23	155	3	of	of	ADP
bptjm-23	155	4	nanoparticles	nanoparticle	NOUN
bptjm-23	155	5	seems	seem	VERB
bptjm-23	155	6	like	like	ADP
bptjm-23	155	7	a	a	DET
bptjm-23	155	8	great	great	ADJ
bptjm-23	155	9	treatment	treatment	NOUN
bptjm-23	155	10	for	for	ADP
bptjm-23	155	11	lung	lung	NOUN
bptjm-23	155	12	disorders	disorder	NOUN
bptjm-23	155	13	,	,	PUNCT
bptjm-23	155	14	it	it	PRON
bptjm-23	155	15	is	be	AUX
bptjm-23	155	16	actually	actually	ADV
bptjm-23	155	17	limited	limit	VERB
bptjm-23	155	18	in	in	ADP
bptjm-23	155	19	some	some	DET
bptjm-23	155	20	copd	copd	NOUN
bptjm-23	155	21	treatments	treatment	NOUN
bptjm-23	155	22	.	.	PUNCT
bptjm-23	156	1	the	the	DET
bptjm-23	156	2	inhalation	inhalation	NOUN
bptjm-23	156	3	of	of	ADP
bptjm-23	156	4	bibw	bibw	NOUN
bptjm-23	156	5	2948	2948	NUM
bptjm-23	156	6	,	,	PUNCT
bptjm-23	156	7	which	which	PRON
bptjm-23	156	8	is	be	AUX
bptjm-23	156	9	used	use	VERB
bptjm-23	156	10	for	for	ADP
bptjm-23	156	11	treating	treat	VERB
bptjm-23	156	12	copd	copd	NOUN
bptjm-23	156	13	,	,	PUNCT
bptjm-23	156	14	helped	help	VERB
bptjm-23	156	15	reduce	reduce	VERB
bptjm-23	156	16	the	the	DET
bptjm-23	156	17	internalization	internalization	NOUN
bptjm-23	156	18	of	of	ADP
bptjm-23	156	19	efgr	efgr	NOUN
bptjm-23	156	20	,	,	PUNCT
bptjm-23	156	21	which	which	PRON
bptjm-23	156	22	plays	play	VERB
bptjm-23	156	23	an	an	DET
bptjm-23	156	24	important	important	ADJ
bptjm-23	156	25	role	role	NOUN
bptjm-23	156	26	in	in	ADP
bptjm-23	156	27	epithelial	epithelial	ADJ
bptjm-23	156	28	changes	change	NOUN
bptjm-23	156	29	in	in	ADP
bptjm-23	156	30	copd	copd	NOUN
bptjm-23	156	31	,	,	PUNCT
bptjm-23	156	32	but	but	CCONJ
bptjm-23	156	33	does	do	AUX
bptjm-23	156	34	not	not	PART
bptjm-23	156	35	reduce	reduce	VERB
bptjm-23	156	36	the	the	DET
bptjm-23	156	37	mucin	mucin	NOUN
bptjm-23	156	38	storage27,28	storage27,28	PROPN
bptjm-23	156	39	.	.	PROPN
bptjm-23	156	40	bambi	bambi	PROPN
bptjm-23	156	41	,	,	PUNCT
bptjm-23	156	42	which	which	PRON
bptjm-23	156	43	is	be	AUX
bptjm-23	156	44	the	the	DET
bptjm-23	156	45	bone	bone	NOUN
bptjm-23	156	46	morphogenic	morphogenic	ADJ
bptjm-23	156	47	protein	protein	NOUN
bptjm-23	156	48	and	and	CCONJ
bptjm-23	156	49	activin	activin	NOUN
bptjm-23	156	50	membrane	membrane	NOUN
bptjm-23	156	51	-	-	PUNCT
bptjm-23	156	52	bound	bind	VERB
bptjm-23	156	53	inhibitor	inhibitor	NOUN
bptjm-23	156	54	,	,	PUNCT
bptjm-23	156	55	plays	play	VERB
bptjm-23	156	56	an	an	DET
bptjm-23	156	57	important	important	ADJ
bptjm-23	156	58	role	role	NOUN
bptjm-23	156	59	in	in	ADP
bptjm-23	156	60	indicating	indicate	VERB
bptjm-23	156	61	if	if	SCONJ
bptjm-23	156	62	a	a	DET
bptjm-23	156	63	patient	patient	NOUN
bptjm-23	156	64	has	have	VERB
bptjm-23	156	65	copd	copd	NOUN
bptjm-23	156	66	.	.	PUNCT
bptjm-23	157	1	bambi	bambi	PROPN
bptjm-23	157	2	are	be	AUX
bptjm-23	157	3	expressed	express	VERB
bptjm-23	157	4	stronger	strong	ADJ
bptjm-23	157	5	in	in	ADP
bptjm-23	157	6	copd	copd	NOUN
bptjm-23	157	7	patients	patient	NOUN
bptjm-23	157	8	[	[	X
bptjm-23	157	9	28	28	NUM
bptjm-23	157	10	]	]	PUNCT
bptjm-23	157	11	.	.	PUNCT
bptjm-23	158	1	also	also	ADV
bptjm-23	158	2	there	there	PRON
bptjm-23	158	3	is	be	VERB
bptjm-23	158	4	a	a	DET
bptjm-23	158	5	correlation	correlation	NOUN
bptjm-23	158	6	between	between	ADP
bptjm-23	158	7	the	the	DET
bptjm-23	158	8	levels	level	NOUN
bptjm-23	158	9	of	of	ADP
bptjm-23	158	10	bambi	bambi	NOUN
bptjm-23	158	11	and	and	CCONJ
bptjm-23	158	12	plasma	plasma	PROPN
bptjm-23	158	13	tgf	tgf	PROPN
bptjm-23	158	14	-β1	-β1	PROPN
bptjm-23	158	15	levels	level	NOUN
bptjm-23	158	16	.	.	PUNCT
bptjm-23	159	1	therefore	therefore	ADV
bptjm-23	159	2	,	,	PUNCT
bptjm-23	159	3	the	the	DET
bptjm-23	159	4	inhibition	inhibition	NOUN
bptjm-23	159	5	of	of	ADP
bptjm-23	159	6	tgf	tgf	PROPN
bptjm-23	159	7	-	-	PUNCT
bptjm-23	159	8	β1	β1	PROPN
bptjm-23	159	9	signaling	signal	VERB
bptjm-23	159	10	might	might	AUX
bptjm-23	159	11	provide	provide	VERB
bptjm-23	159	12	an	an	DET
bptjm-23	159	13	alternative	alternative	ADJ
bptjm-23	159	14	therapeutic	therapeutic	ADJ
bptjm-23	159	15	strategy	strategy	NOUN
bptjm-23	159	16	for	for	ADP
bptjm-23	159	17	treating	treat	VERB
bptjm-23	159	18	copd28	copd28	PROPN
bptjm-23	159	19	.	.	PUNCT
bptjm-23	160	1	inhale	inhale	NOUN
bptjm-23	160	2	gene	gene	NOUN
bptjm-23	160	3	therapy	therapy	NOUN
bptjm-23	160	4	another	another	DET
bptjm-23	160	5	potential	potential	ADJ
bptjm-23	160	6	therapeutic	therapeutic	ADJ
bptjm-23	160	7	treatment	treatment	NOUN
bptjm-23	160	8	for	for	ADP
bptjm-23	160	9	copd	copd	NOUN
bptjm-23	160	10	is	be	AUX
bptjm-23	160	11	through	through	ADP
bptjm-23	160	12	inhaled	inhaled	ADJ
bptjm-23	160	13	gene	gene	NOUN
bptjm-23	160	14	therapy	therapy	NOUN
bptjm-23	160	15	.	.	PUNCT
bptjm-23	161	1	this	this	DET
bptjm-23	161	2	treatment	treatment	NOUN
bptjm-23	161	3	provides	provide	VERB
bptjm-23	161	4	direct	direct	ADJ
bptjm-23	161	5	access	access	NOUN
bptjm-23	161	6	to	to	ADP
bptjm-23	161	7	the	the	DET
bptjm-23	161	8	target	target	NOUN
bptjm-23	161	9	of	of	ADP
bptjm-23	161	10	gene	gene	NOUN
bptjm-23	161	11	therapy	therapy	NOUN
bptjm-23	161	12	for	for	ADP
bptjm-23	161	13	obstructive	obstructive	ADJ
bptjm-23	161	14	lung	lung	NOUN
bptjm-23	161	15	diseases	disease	NOUN
bptjm-23	161	16	via	via	ADP
bptjm-23	161	17	inhalation	inhalation	NOUN
bptjm-23	161	18	.	.	PUNCT
bptjm-23	162	1	there	there	PRON
bptjm-23	162	2	are	be	VERB
bptjm-23	162	3	limitations	limitation	NOUN
bptjm-23	162	4	that	that	PRON
bptjm-23	162	5	surround	surround	VERB
bptjm-23	162	6	inhale	inhale	NOUN
bptjm-23	162	7	gene	gene	NOUN
bptjm-23	162	8	therapy	therapy	NOUN
bptjm-23	162	9	.	.	PUNCT
bptjm-23	163	1	in	in	ADP
bptjm-23	163	2	a	a	DET
bptjm-23	163	3	study	study	NOUN
bptjm-23	163	4	conducted	conduct	VERB
bptjm-23	163	5	by	by	ADP
bptjm-23	163	6	dr	dr	PROPN
bptjm-23	163	7	.	.	PROPN
bptjm-23	163	8	magdalena	magdalena	PROPN
bptjm-23	163	9	humenberger	humenberger	PROPN
bptjm-23	163	10	from	from	ADP
bptjm-23	163	11	the	the	DET
bptjm-23	163	12	kepler	kepler	PROPN
bptjm-23	163	13	university	university	PROPN
bptjm-23	163	14	hospital	hospital	NOUN
bptjm-23	163	15	in	in	ADP
bptjm-23	163	16	austria	austria	PROPN
bptjm-23	163	17	concluded	conclude	VERB
bptjm-23	163	18	that	that	SCONJ
bptjm-23	163	19	complete	complete	ADJ
bptjm-23	163	20	adherence	adherence	NOUN
bptjm-23	163	21	to	to	ADP
bptjm-23	163	22	inhaled	inhaled	ADJ
bptjm-23	163	23	therapy	therapy	NOUN
bptjm-23	163	24	was	be	AUX
bptjm-23	163	25	only	only	ADV
bptjm-23	163	26	seen	see	VERB
bptjm-23	163	27	in	in	ADP
bptjm-23	163	28	33.6	33.6	NUM
bptjm-23	163	29	%	%	NOUN
bptjm-23	163	30	and	and	CCONJ
bptjm-23	163	31	was	be	AUX
bptjm-23	163	32	higher	high	ADJ
bptjm-23	163	33	among	among	ADP
bptjm-23	163	34	those	those	PRON
bptjm-23	163	35	with	with	ADP
bptjm-23	163	36	more	more	ADV
bptjm-23	163	37	severe	severe	ADJ
bptjm-23	163	38	copd	copd	NOUN
bptjm-23	163	39	,	,	PUNCT
bptjm-23	163	40	based	base	VERB
bptjm-23	163	41	on	on	ADP
bptjm-23	163	42	these	these	DET
bptjm-23	163	43	results47	results47	NOUN
bptjm-23	163	44	.	.	PUNCT
bptjm-23	164	1	it	it	PRON
bptjm-23	164	2	was	be	AUX
bptjm-23	164	3	shown	show	VERB
bptjm-23	164	4	that	that	SCONJ
bptjm-23	164	5	mucus	mucus	NOUN
bptjm-23	164	6	poses	pose	VERB
bptjm-23	164	7	a	a	DET
bptjm-23	164	8	barrier	barrier	NOUN
bptjm-23	164	9	for	for	ADP
bptjm-23	164	10	this	this	DET
bptjm-23	164	11	speci	speci	ADJ
bptjm-23	164	12	�	�	PROPN
bptjm-23	164	13	c	c	NOUN
bptjm-23	164	14	treatment	treatment	NOUN
bptjm-23	164	15	.	.	PUNCT
bptjm-23	165	1	although	although	SCONJ
bptjm-23	165	2	this	this	PRON
bptjm-23	165	3	is	be	AUX
bptjm-23	165	4	a	a	DET
bptjm-23	165	5	current	current	ADJ
bptjm-23	165	6	problem	problem	NOUN
bptjm-23	165	7	,	,	PUNCT
bptjm-23	165	8	other	other	ADJ
bptjm-23	165	9	studies	study	NOUN
bptjm-23	165	10	have	have	AUX
bptjm-23	165	11	mentioned	mention	VERB
bptjm-23	165	12	a	a	DET
bptjm-23	165	13	di	di	NOUN
bptjm-23	165	14	�	�	PROPN
bptjm-23	165	15	erent	erent	NOUN
bptjm-23	165	16	type	type	NOUN
bptjm-23	165	17	of	of	ADP
bptjm-23	165	18	gene	gene	NOUN
bptjm-23	165	19	vector	vector	NOUN
bptjm-23	165	20	that	that	PRON
bptjm-23	165	21	could	could	AUX
bptjm-23	165	22	be	be	AUX
bptjm-23	165	23	inhaled	inhale	VERB
bptjm-23	165	24	that	that	PRON
bptjm-23	165	25	would	would	AUX
bptjm-23	165	26	penetrate	penetrate	VERB
bptjm-23	165	27	that	that	DET
bptjm-23	165	28	mucus	mucus	NOUN
bptjm-23	165	29	barrier	barrier	NOUN
bptjm-23	165	30	.	.	PUNCT
bptjm-23	166	1	a	a	DET
bptjm-23	166	2	type	type	NOUN
bptjm-23	166	3	of	of	ADP
bptjm-23	166	4	nanoparticle	nanoparticle	NOUN
bptjm-23	166	5	that	that	PRON
bptjm-23	166	6	was	be	AUX
bptjm-23	166	7	introduced	introduce	VERB
bptjm-23	166	8	by	by	ADP
bptjm-23	166	9	berkeley	berkeley	PROPN
bptjm-23	166	10	pharma	pharma	PROPN
bptjm-23	166	11	tech	tech	NOUN
bptjm-23	166	12	journal	journal	NOUN
bptjm-23	166	13	of	of	ADP
bptjm-23	166	14	medicine	medicine	NOUN
bptjm-23	166	15	|	|	ADV
bptjm-23	166	16	71	71	NUM
bptjm-23	166	17	dr	dr	PROPN
bptjm-23	166	18	.	.	PROPN
bptjm-23	166	19	jung	jung	PROPN
bptjm-23	166	20	soo	soo	PROPN
bptjm-23	166	21	suk	suk	PROPN
bptjm-23	166	22	,	,	PUNCT
bptjm-23	166	23	from	from	ADP
bptjm-23	166	24	the	the	DET
bptjm-23	166	25	the	the	DET
bptjm-23	166	26	center	center	NOUN
bptjm-23	166	27	for	for	ADP
bptjm-23	166	28	nanomedicine	nanomedicine	NOUN
bptjm-23	166	29	in	in	ADP
bptjm-23	166	30	the	the	DET
bptjm-23	166	31	johns	johns	PROPN
bptjm-23	166	32	hopkins	hopkins	PROPN
bptjm-23	166	33	university	university	PROPN
bptjm-23	166	34	school	school	NOUN
bptjm-23	166	35	of	of	ADP
bptjm-23	166	36	medicine	medicine	NOUN
bptjm-23	166	37	,	,	PUNCT
bptjm-23	166	38	was	be	AUX
bptjm-23	166	39	the	the	DET
bptjm-23	166	40	mucus	mucus	NOUN
bptjm-23	166	41	-	-	PUNCT
bptjm-23	166	42	penetrating	penetrate	VERB
bptjm-23	166	43	dna	dna	PROPN
bptjm-23	166	44	nanoparticles	nanoparticle	NOUN
bptjm-23	166	45	(	(	PUNCT
bptjm-23	166	46	dna	dna	NOUN
bptjm-23	166	47	-	-	PUNCT
bptjm-23	166	48	mpp	mpp	NOUN
bptjm-23	166	49	)	)	PUNCT
bptjm-23	166	50	,	,	PUNCT
bptjm-23	166	51	which	which	PRON
bptjm-23	166	52	possess	possess	VERB
bptjm-23	166	53	non	non	ADJ
bptjm-23	166	54	-	-	ADJ
bptjm-23	166	55	adhesive	adhesive	ADJ
bptjm-23	166	56	coatings	coating	NOUN
bptjm-23	166	57	that	that	PRON
bptjm-23	166	58	allow	allow	VERB
bptjm-23	166	59	them	they	PRON
bptjm-23	166	60	to	to	PART
bptjm-23	166	61	rapidly	rapidly	ADV
bptjm-23	166	62	penetrate	penetrate	VERB
bptjm-23	166	63	mucus	mucus	NOUN
bptjm-23	166	64	layers48	layers48	NOUN
bptjm-23	166	65	.	.	PUNCT
bptjm-23	167	1	the	the	DET
bptjm-23	167	2	peg	peg	NOUN
bptjm-23	167	3	coating	coating	NOUN
bptjm-23	167	4	helps	help	VERB
bptjm-23	167	5	with	with	ADP
bptjm-23	167	6	the	the	DET
bptjm-23	167	7	dna	dna	PROPN
bptjm-23	167	8	-	-	PUNCT
bptjm-23	167	9	mpp	mpp	NOUN
bptjm-23	167	10	treatment	treatment	NOUN
bptjm-23	167	11	since	since	SCONJ
bptjm-23	167	12	it	it	PRON
bptjm-23	167	13	does	do	AUX
bptjm-23	167	14	not	not	PART
bptjm-23	167	15	have	have	VERB
bptjm-23	167	16	a	a	DET
bptjm-23	167	17	dense	dense	ADJ
bptjm-23	167	18	surface	surface	NOUN
bptjm-23	167	19	,	,	PUNCT
bptjm-23	167	20	helping	help	VERB
bptjm-23	167	21	the	the	DET
bptjm-23	167	22	nanoparticle	nanoparticle	NOUN
bptjm-23	167	23	to	to	PART
bptjm-23	167	24	penetrate	penetrate	VERB
bptjm-23	167	25	other	other	ADJ
bptjm-23	167	26	mucin	mucin	NOUN
bptjm-23	167	27	-	-	PUNCT
bptjm-23	167	28	based	base	VERB
bptjm-23	167	29	meshwork48	meshwork48	NOUN
bptjm-23	167	30	.	.	PUNCT
bptjm-23	168	1	stem	stem	NOUN
bptjm-23	168	2	cell	cell	NOUN
bptjm-23	168	3	therapy	therapy	NOUN
bptjm-23	168	4	another	another	DET
bptjm-23	168	5	potential	potential	ADJ
bptjm-23	168	6	way	way	NOUN
bptjm-23	168	7	of	of	ADP
bptjm-23	168	8	treating	treat	VERB
bptjm-23	168	9	copd	copd	NOUN
bptjm-23	168	10	is	be	AUX
bptjm-23	168	11	through	through	ADP
bptjm-23	168	12	stem	stem	NOUN
bptjm-23	168	13	cell	cell	NOUN
bptjm-23	168	14	therapy	therapy	NOUN
bptjm-23	168	15	.	.	PUNCT
bptjm-23	169	1	this	this	DET
bptjm-23	169	2	treatment	treatment	NOUN
bptjm-23	169	3	is	be	AUX
bptjm-23	169	4	considered	consider	VERB
bptjm-23	169	5	one	one	NUM
bptjm-23	169	6	of	of	ADP
bptjm-23	169	7	the	the	DET
bptjm-23	169	8	newer	new	ADJ
bptjm-23	169	9	treatments	treatment	NOUN
bptjm-23	169	10	that	that	PRON
bptjm-23	169	11	still	still	ADV
bptjm-23	169	12	has	have	VERB
bptjm-23	169	13	a	a	DET
bptjm-23	169	14	lot	lot	NOUN
bptjm-23	169	15	of	of	ADP
bptjm-23	169	16	questions	question	NOUN
bptjm-23	169	17	�	�	NOUN
bptjm-23	169	18	oating	oate	VERB
bptjm-23	169	19	around	around	ADP
bptjm-23	169	20	it	it	PRON
bptjm-23	169	21	.	.	PUNCT
bptjm-23	170	1	although	although	SCONJ
bptjm-23	170	2	stem	stem	NOUN
bptjm-23	170	3	cell	cell	NOUN
bptjm-23	170	4	therapy	therapy	NOUN
bptjm-23	170	5	is	be	AUX
bptjm-23	170	6	not	not	PART
bptjm-23	170	7	considered	consider	VERB
bptjm-23	170	8	safe	safe	ADJ
bptjm-23	170	9	,	,	PUNCT
bptjm-23	170	10	it	it	PRON
bptjm-23	170	11	still	still	ADV
bptjm-23	170	12	has	have	VERB
bptjm-23	170	13	potential	potential	ADJ
bptjm-23	170	14	when	when	SCONJ
bptjm-23	170	15	it	it	PRON
bptjm-23	170	16	comes	come	VERB
bptjm-23	170	17	to	to	ADP
bptjm-23	170	18	treating	treat	VERB
bptjm-23	170	19	disorders	disorder	NOUN
bptjm-23	170	20	such	such	ADJ
bptjm-23	170	21	as	as	ADP
bptjm-23	170	22	copd	copd	NOUN
bptjm-23	170	23	.	.	PUNCT
bptjm-23	171	1	recently	recently	ADV
bptjm-23	171	2	there	there	PRON
bptjm-23	171	3	have	have	AUX
bptjm-23	171	4	been	be	AUX
bptjm-23	171	5	several	several	ADJ
bptjm-23	171	6	studies	study	NOUN
bptjm-23	171	7	and	and	CCONJ
bptjm-23	171	8	clinical	clinical	ADJ
bptjm-23	171	9	trials	trial	NOUN
bptjm-23	171	10	that	that	PRON
bptjm-23	171	11	have	have	AUX
bptjm-23	171	12	focused	focus	VERB
bptjm-23	171	13	on	on	ADP
bptjm-23	171	14	stem	stem	NOUN
bptjm-23	171	15	cell	cell	NOUN
bptjm-23	171	16	treatment	treatment	NOUN
bptjm-23	171	17	.	.	PUNCT
bptjm-23	172	1	the	the	DET
bptjm-23	172	2	studies	study	NOUN
bptjm-23	172	3	on	on	ADP
bptjm-23	172	4	copd	copd	PROPN
bptjm-23	172	5	focused	focus	VERB
bptjm-23	172	6	on	on	ADP
bptjm-23	172	7	a	a	DET
bptjm-23	172	8	speci	speci	ADJ
bptjm-23	172	9	�	�	PROPN
bptjm-23	172	10	c	c	NOUN
bptjm-23	172	11	stem	stem	NOUN
bptjm-23	172	12	cell	cell	NOUN
bptjm-23	172	13	treatment	treatment	NOUN
bptjm-23	172	14	called	call	VERB
bptjm-23	172	15	mesenchymal	mesenchymal	NOUN
bptjm-23	172	16	stem	stem	NOUN
bptjm-23	172	17	cells	cell	NOUN
bptjm-23	172	18	(	(	PUNCT
bptjm-23	172	19	mscs	msc	NOUN
bptjm-23	172	20	)	)	PUNCT
bptjm-23	172	21	,	,	PUNCT
bptjm-23	172	22	which	which	PRON
bptjm-23	172	23	is	be	AUX
bptjm-23	172	24	important	important	ADJ
bptjm-23	172	25	for	for	ADP
bptjm-23	172	26	making	make	VERB
bptjm-23	172	27	and	and	CCONJ
bptjm-23	172	28	repairing	repair	VERB
bptjm-23	172	29	skeletal	skeletal	ADJ
bptjm-23	172	30	tissues49	tissues49	NOUN
bptjm-23	172	31	.	.	PUNCT
bptjm-23	173	1	in	in	ADP
bptjm-23	173	2	a	a	DET
bptjm-23	173	3	clinical	clinical	ADJ
bptjm-23	173	4	study	study	NOUN
bptjm-23	173	5	,	,	PUNCT
bptjm-23	173	6	they	they	PRON
bptjm-23	173	7	were	be	AUX
bptjm-23	173	8	infused	infuse	VERB
bptjm-23	173	9	with	with	ADP
bptjm-23	173	10	expanded	expand	VERB
bptjm-23	173	11	allogeneic	allogeneic	ADJ
bptjm-23	173	12	umbilical	umbilical	ADJ
bptjm-23	173	13	cord	cord	NOUN
bptjm-23	173	14	tissue	tissue	NOUN
bptjm-23	173	15	derived	derive	VERB
bptjm-23	173	16	mesenchymal	mesenchymal	NOUN
bptjm-23	173	17	stem	stem	NOUN
bptjm-23	173	18	cells	cell	NOUN
bptjm-23	173	19	(	(	PUNCT
bptjm-23	173	20	mscs	msc	NOUN
bptjm-23	173	21	)	)	PUNCT
bptjm-23	173	22	to	to	ADP
bptjm-23	173	23	20	20	NUM
bptjm-23	173	24	copd	copd	NOUN
bptjm-23	173	25	patients	patient	NOUN
bptjm-23	173	26	and	and	CCONJ
bptjm-23	173	27	then	then	ADV
bptjm-23	173	28	were	be	AUX
bptjm-23	173	29	monitored	monitor	VERB
bptjm-23	173	30	for	for	ADP
bptjm-23	173	31	6	6	NUM
bptjm-23	173	32	months49	months49	NOUN
bptjm-23	173	33	.	.	PUNCT
bptjm-23	174	1	this	this	DET
bptjm-23	174	2	study	study	NOUN
bptjm-23	174	3	concluded	conclude	VERB
bptjm-23	174	4	a	a	DET
bptjm-23	174	5	signi	signi	ADJ
bptjm-23	174	6	�	�	NOUN
bptjm-23	174	7	cant	cant	VERB
bptjm-23	174	8	improvement	improvement	NOUN
bptjm-23	174	9	in	in	ADP
bptjm-23	174	10	some	some	DET
bptjm-23	174	11	important	important	ADJ
bptjm-23	174	12	outcomes	outcome	NOUN
bptjm-23	174	13	of	of	ADP
bptjm-23	174	14	copd	copd	NOUN
bptjm-23	174	15	,	,	PUNCT
bptjm-23	174	16	including	include	VERB
bptjm-23	174	17	mmcr	mmcr	ADJ
bptjm-23	174	18	,	,	PUNCT
bptjm-23	174	19	cat	cat	NOUN
bptjm-23	174	20	,	,	PUNCT
bptjm-23	174	21	number	number	NOUN
bptjm-23	174	22	of	of	ADP
bptjm-23	174	23	symptoms	symptom	NOUN
bptjm-23	174	24	,	,	PUNCT
bptjm-23	174	25	and	and	CCONJ
bptjm-23	174	26	the	the	DET
bptjm-23	174	27	downregulation	downregulation	NOUN
bptjm-23	174	28	of	of	ADP
bptjm-23	174	29	in	in	ADP
bptjm-23	174	30	�	�	PROPN
bptjm-23	174	31	ammation49	ammation49	NOUN
bptjm-23	174	32	.	.	PUNCT
bptjm-23	175	1	although	although	SCONJ
bptjm-23	175	2	this	this	DET
bptjm-23	175	3	study	study	NOUN
bptjm-23	175	4	is	be	AUX
bptjm-23	175	5	considered	consider	VERB
bptjm-23	175	6	a	a	DET
bptjm-23	175	7	pilot	pilot	NOUN
bptjm-23	175	8	study	study	NOUN
bptjm-23	175	9	,	,	PUNCT
bptjm-23	175	10	a	a	DET
bptjm-23	175	11	small	small	ADJ
bptjm-23	175	12	scale	scale	NOUN
bptjm-23	175	13	clinical	clinical	ADJ
bptjm-23	175	14	study	study	NOUN
bptjm-23	175	15	,	,	PUNCT
bptjm-23	175	16	it	it	PRON
bptjm-23	175	17	provides	provide	VERB
bptjm-23	175	18	a	a	DET
bptjm-23	175	19	unique	unique	ADJ
bptjm-23	175	20	perspective	perspective	NOUN
bptjm-23	175	21	when	when	SCONJ
bptjm-23	175	22	it	it	PRON
bptjm-23	175	23	comes	come	VERB
bptjm-23	175	24	to	to	ADP
bptjm-23	175	25	treating	treat	VERB
bptjm-23	175	26	copd	copd	NOUN
bptjm-23	175	27	via	via	ADP
bptjm-23	175	28	stem	stem	NOUN
bptjm-23	175	29	cell	cell	NOUN
bptjm-23	175	30	therapy	therapy	NOUN
bptjm-23	175	31	.	.	PUNCT
bptjm-23	176	1	alpha1	alpha1	NOUN
bptjm-23	176	2	-	-	PUNCT
bptjm-23	176	3	antitrypsin	antitrypsin	NOUN
bptjm-23	176	4	alpha1	alpha1	NOUN
bptjm-23	176	5	-	-	PUNCT
bptjm-23	176	6	antitrypsin	antitrypsin	NOUN
bptjm-23	176	7	(	(	PUNCT
bptjm-23	176	8	a1at	a1at	X
bptjm-23	176	9	)	)	PUNCT
bptjm-23	176	10	is	be	AUX
bptjm-23	176	11	a	a	DET
bptjm-23	176	12	protease	protease	NOUN
bptjm-23	176	13	inhibitor	inhibitor	NOUN
bptjm-23	176	14	whose	whose	DET
bptjm-23	176	15	de	de	NOUN
bptjm-23	176	16	�	�	NOUN
bptjm-23	176	17	ciency	ciency	NOUN
bptjm-23	176	18	is	be	AUX
bptjm-23	176	19	most	most	ADV
bptjm-23	176	20	commonly	commonly	ADV
bptjm-23	176	21	associated	associate	VERB
bptjm-23	176	22	with	with	ADP
bptjm-23	176	23	the	the	DET
bptjm-23	176	24	zz	zz	PROPN
bptjm-23	176	25	mutation	mutation	NOUN
bptjm-23	176	26	which	which	PRON
bptjm-23	176	27	causes	cause	VERB
bptjm-23	176	28	abnormal	abnormal	ADJ
bptjm-23	176	29	folding	folding	NOUN
bptjm-23	176	30	in	in	ADP
bptjm-23	176	31	the	the	DET
bptjm-23	176	32	er	er	INTJ
bptjm-23	176	33	of	of	ADP
bptjm-23	176	34	hepatocytes	hepatocyte	NOUN
bptjm-23	176	35	during	during	ADP
bptjm-23	176	36	biogenesis	biogenesis	NOUN
bptjm-23	176	37	,	,	PUNCT
bptjm-23	176	38	causing	cause	VERB
bptjm-23	176	39	its	its	PRON
bptjm-23	176	40	retention	retention	NOUN
bptjm-23	176	41	within	within	ADP
bptjm-23	176	42	the	the	DET
bptjm-23	176	43	er	er	INTJ
bptjm-23	176	44	.	.	PUNCT
bptjm-23	177	1	the	the	DET
bptjm-23	177	2	retention	retention	NOUN
bptjm-23	177	3	of	of	ADP
bptjm-23	177	4	90	90	NUM
bptjm-23	177	5	%	%	NOUN
bptjm-23	177	6	of	of	ADP
bptjm-23	177	7	the	the	DET
bptjm-23	177	8	normal	normal	ADJ
bptjm-23	177	9	a1at	a1at	NOUN
bptjm-23	177	10	levels	level	NOUN
bptjm-23	177	11	greatly	greatly	ADV
bptjm-23	177	12	increases	increase	VERB
bptjm-23	177	13	the	the	DET
bptjm-23	177	14	risk	risk	NOUN
bptjm-23	177	15	for	for	ADP
bptjm-23	177	16	early	early	ADJ
bptjm-23	177	17	onset	onset	NOUN
bptjm-23	177	18	copd50	copd50	NOUN
bptjm-23	177	19	.	.	PUNCT
bptjm-23	178	1	in	in	ADP
bptjm-23	178	2	a	a	DET
bptjm-23	178	3	large	large	ADJ
bptjm-23	178	4	lithuanian	lithuanian	NOUN
bptjm-23	178	5	cohort	cohort	NOUN
bptjm-23	178	6	,	,	PUNCT
bptjm-23	178	7	out	out	ADP
bptjm-23	178	8	of	of	ADP
bptjm-23	178	9	1167	1167	NUM
bptjm-23	178	10	patients	patient	NOUN
bptjm-23	178	11	who	who	PRON
bptjm-23	178	12	had	have	VERB
bptjm-23	178	13	copd	copd	NOUN
bptjm-23	178	14	ranging	range	VERB
bptjm-23	178	15	from	from	ADP
bptjm-23	178	16	moderate	moderate	ADJ
bptjm-23	178	17	to	to	AUX
bptjm-23	178	18	severe	severe	ADJ
bptjm-23	178	19	,	,	PUNCT
bptjm-23	178	20	3.4	3.4	NUM
bptjm-23	178	21	%	%	NOUN
bptjm-23	178	22	had	have	VERB
bptjm-23	178	23	the	the	DET
bptjm-23	178	24	mz	mz	PROPN
bptjm-23	178	25	mutation	mutation	NOUN
bptjm-23	178	26	,	,	PUNCT
bptjm-23	178	27	3.3	3.3	NUM
bptjm-23	178	28	%	%	NOUN
bptjm-23	178	29	had	have	VERB
bptjm-23	178	30	the	the	DET
bptjm-23	178	31	ms	ms	PROPN
bptjm-23	178	32	mutation	mutation	NOUN
bptjm-23	178	33	,	,	PUNCT
bptjm-23	178	34	0.3	0.3	NUM
bptjm-23	178	35	%	%	NOUN
bptjm-23	178	36	had	have	VERB
bptjm-23	178	37	the	the	DET
bptjm-23	178	38	sz	sz	NOUN
bptjm-23	178	39	mutation	mutation	NOUN
bptjm-23	178	40	,	,	PUNCT
bptjm-23	178	41	and	and	CCONJ
bptjm-23	178	42	0.7	0.7	NUM
bptjm-23	178	43	%	%	NOUN
bptjm-23	178	44	had	have	VERB
bptjm-23	178	45	the	the	DET
bptjm-23	178	46	zz	zz	PROPN
bptjm-23	178	47	mutations	mutation	NOUN
bptjm-23	178	48	.	.	PUNCT
bptjm-23	179	1	results	result	NOUN
bptjm-23	179	2	from	from	ADP
bptjm-23	179	3	the	the	DET
bptjm-23	179	4	screen	screen	NOUN
bptjm-23	179	5	indicated	indicate	VERB
bptjm-23	179	6	that	that	SCONJ
bptjm-23	179	7	there	there	ADV
bptjm-23	179	8	berkeley	berkeley	PROPN
bptjm-23	179	9	pharma	pharma	PROPN
bptjm-23	179	10	tech	tech	NOUN
bptjm-23	179	11	journal	journal	NOUN
bptjm-23	179	12	of	of	ADP
bptjm-23	179	13	medicine	medicine	NOUN
bptjm-23	179	14	|	|	ADV
bptjm-23	179	15	72	72	NUM
bptjm-23	179	16	was	be	AUX
bptjm-23	179	17	a	a	DET
bptjm-23	179	18	signi	signi	ADJ
bptjm-23	179	19	�	�	NOUN
bptjm-23	179	20	cant	cant	NOUN
bptjm-23	179	21	increase	increase	NOUN
bptjm-23	179	22	in	in	ADP
bptjm-23	179	23	mz	mz	PROPN
bptjm-23	179	24	,	,	PUNCT
bptjm-23	179	25	sz	sz	PROPN
bptjm-23	179	26	and	and	CCONJ
bptjm-23	179	27	zz	zz	PROPN
bptjm-23	179	28	genotypes	genotype	NOUN
bptjm-23	179	29	in	in	ADP
bptjm-23	179	30	copd	copd	NOUN
bptjm-23	179	31	patients	patient	NOUN
bptjm-23	179	32	;	;	PUNCT
bptjm-23	179	33	it	it	PRON
bptjm-23	179	34	also	also	ADV
bptjm-23	179	35	supported	support	VERB
bptjm-23	179	36	the	the	DET
bptjm-23	179	37	concept	concept	NOUN
bptjm-23	179	38	of	of	ADP
bptjm-23	179	39	using	use	VERB
bptjm-23	179	40	a	a	DET
bptjm-23	179	41	targeted	target	VERB
bptjm-23	179	42	screen	screen	NOUN
bptjm-23	179	43	for	for	ADP
bptjm-23	179	44	a1at	a1at	X
bptjm-23	179	45	de	de	X
bptjm-23	179	46	�	�	NOUN
bptjm-23	179	47	ciency	ciency	NOUN
bptjm-23	179	48	when	when	SCONJ
bptjm-23	179	49	diagnosing	diagnose	VERB
bptjm-23	179	50	copd51	copd51	VERB
bptjm-23	179	51	.	.	PUNCT
bptjm-23	180	1	another	another	DET
bptjm-23	180	2	study	study	NOUN
bptjm-23	180	3	conducted	conduct	VERB
bptjm-23	180	4	in	in	ADP
bptjm-23	180	5	brazil	brazil	PROPN
bptjm-23	180	6	on	on	ADP
bptjm-23	180	7	926	926	NUM
bptjm-23	180	8	copd	copd	NOUN
bptjm-23	180	9	patients	patient	NOUN
bptjm-23	180	10	found	find	VERB
bptjm-23	180	11	that	that	SCONJ
bptjm-23	180	12	2.8	2.8	NUM
bptjm-23	180	13	%	%	NOUN
bptjm-23	180	14	had	have	AUX
bptjm-23	180	15	a1at	a1at	AUX
bptjm-23	180	16	de	de	X
bptjm-23	180	17	�	�	NOUN
bptjm-23	180	18	ciencies	ciencie	NOUN
bptjm-23	180	19	and	and	CCONJ
bptjm-23	180	20	0.8	0.8	NUM
bptjm-23	180	21	%	%	NOUN
bptjm-23	180	22	had	have	VERB
bptjm-23	180	23	the	the	DET
bptjm-23	180	24	zz	zz	PROPN
bptjm-23	180	25	mutation	mutation	NOUN
bptjm-23	180	26	.	.	PUNCT
bptjm-23	181	1	these	these	DET
bptjm-23	181	2	results	result	NOUN
bptjm-23	181	3	also	also	ADV
bptjm-23	181	4	supported	support	VERB
bptjm-23	181	5	the	the	DET
bptjm-23	181	6	importance	importance	NOUN
bptjm-23	181	7	of	of	ADP
bptjm-23	181	8	screening	screen	VERB
bptjm-23	181	9	for	for	ADP
bptjm-23	181	10	a1at	a1at	PROPN
bptjm-23	181	11	levels	level	NOUN
bptjm-23	181	12	in	in	ADP
bptjm-23	181	13	all	all	DET
bptjm-23	181	14	copd	copd	PROPN
bptjm-23	181	15	patients52	patients52	NOUN
bptjm-23	181	16	.	.	PUNCT
bptjm-23	182	1	mirna	mirna	PROPN
bptjm-23	182	2	mirnas	mirna	NOUN
bptjm-23	182	3	play	play	VERB
bptjm-23	182	4	an	an	DET
bptjm-23	182	5	important	important	ADJ
bptjm-23	182	6	role	role	NOUN
bptjm-23	182	7	in	in	ADP
bptjm-23	182	8	lung	lung	NOUN
bptjm-23	182	9	development	development	NOUN
bptjm-23	182	10	,	,	PUNCT
bptjm-23	182	11	homeostasis	homeostasis	NOUN
bptjm-23	182	12	,	,	PUNCT
bptjm-23	182	13	and	and	CCONJ
bptjm-23	182	14	pathogenesis	pathogenesis	NOUN
bptjm-23	182	15	.	.	PUNCT
bptjm-23	183	1	they	they	PRON
bptjm-23	183	2	also	also	ADV
bptjm-23	183	3	play	play	VERB
bptjm-23	183	4	a	a	DET
bptjm-23	183	5	role	role	NOUN
bptjm-23	183	6	in	in	ADP
bptjm-23	183	7	the	the	DET
bptjm-23	183	8	regulation	regulation	NOUN
bptjm-23	183	9	of	of	ADP
bptjm-23	183	10	cellular	cellular	ADJ
bptjm-23	183	11	response	response	NOUN
bptjm-23	183	12	to	to	ADP
bptjm-23	183	13	inhaled	inhale	VERB
bptjm-23	183	14	toxins	toxin	NOUN
bptjm-23	183	15	and	and	CCONJ
bptjm-23	183	16	in	in	ADP
bptjm-23	183	17	regulation	regulation	NOUN
bptjm-23	183	18	of	of	ADP
bptjm-23	183	19	in	in	ADP
bptjm-23	183	20	�	�	NOUN
bptjm-23	183	21	ammatory	ammatory	NOUN
bptjm-23	183	22	and	and	CCONJ
bptjm-23	183	23	anti	anti	ADJ
bptjm-23	183	24	-	-	ADJ
bptjm-23	183	25	in	in	ADP
bptjm-23	183	26	�	�	NOUN
bptjm-23	183	27	ammatory	ammatory	NOUN
bptjm-23	183	28	processes	process	NOUN
bptjm-23	183	29	.	.	PUNCT
bptjm-23	184	1	mirnas	mirna	NOUN
bptjm-23	184	2	are	be	AUX
bptjm-23	184	3	one	one	NUM
bptjm-23	184	4	of	of	ADP
bptjm-23	184	5	the	the	DET
bptjm-23	184	6	primary	primary	ADJ
bptjm-23	184	7	epigenetic	epigenetic	ADJ
bptjm-23	184	8	modi	modi	PROPN
bptjm-23	184	9	�	�	PROPN
bptjm-23	184	10	ers	er	NOUN
bptjm-23	184	11	that	that	PRON
bptjm-23	184	12	can	can	AUX
bptjm-23	184	13	a	a	DET
bptjm-23	184	14	�	�	NOUN
bptjm-23	184	15	ect	ect	ADJ
bptjm-23	184	16	gene	gene	NOUN
bptjm-23	184	17	expression	expression	NOUN
bptjm-23	184	18	through	through	ADP
bptjm-23	184	19	post	post	ADJ
bptjm-23	184	20	-	-	ADJ
bptjm-23	184	21	translational	translational	ADJ
bptjm-23	184	22	gene	gene	NOUN
bptjm-23	184	23	silencing	silence	VERB
bptjm-23	184	24	and	and	CCONJ
bptjm-23	184	25	mrna	mrna	PROPN
bptjm-23	184	26	degradation	degradation	NOUN
bptjm-23	184	27	.	.	PUNCT
bptjm-23	185	1	their	their	PRON
bptjm-23	185	2	improper	improper	ADJ
bptjm-23	185	3	regulation	regulation	NOUN
bptjm-23	185	4	can	can	AUX
bptjm-23	185	5	lead	lead	VERB
bptjm-23	185	6	to	to	ADP
bptjm-23	185	7	chronic	chronic	ADJ
bptjm-23	185	8	infections	infection	NOUN
bptjm-23	185	9	and	and	CCONJ
bptjm-23	185	10	in	in	ADP
bptjm-23	185	11	�	�	PROPN
bptjm-23	185	12	ammation	ammation	NOUN
bptjm-23	185	13	.	.	PUNCT
bptjm-23	186	1	a	a	DET
bptjm-23	186	2	study	study	NOUN
bptjm-23	186	3	was	be	AUX
bptjm-23	186	4	done	do	VERB
bptjm-23	186	5	that	that	PRON
bptjm-23	186	6	obtained	obtain	VERB
bptjm-23	186	7	lung	lung	NOUN
bptjm-23	186	8	tissue	tissue	NOUN
bptjm-23	186	9	samples	sample	NOUN
bptjm-23	186	10	from	from	ADP
bptjm-23	186	11	15	15	NUM
bptjm-23	186	12	copd	copd	NOUN
bptjm-23	186	13	patients	patient	NOUN
bptjm-23	186	14	and	and	CCONJ
bptjm-23	186	15	11	11	NUM
bptjm-23	186	16	subjects	subject	NOUN
bptjm-23	186	17	with	with	ADP
bptjm-23	186	18	normal	normal	ADJ
bptjm-23	186	19	lung	lung	NOUN
bptjm-23	186	20	function	function	NOUN
bptjm-23	186	21	.	.	PUNCT
bptjm-23	187	1	12	12	NUM
bptjm-23	187	2	di	di	NOUN
bptjm-23	187	3	�	�	PROPN
bptjm-23	187	4	erentially	erentially	ADV
bptjm-23	187	5	expressed	express	VERB
bptjm-23	187	6	mirna	mirna	NOUN
bptjm-23	187	7	in	in	ADP
bptjm-23	187	8	copd	copd	NOUN
bptjm-23	187	9	patients	patient	NOUN
bptjm-23	187	10	compared	compare	VERB
bptjm-23	187	11	to	to	ADP
bptjm-23	187	12	subjects	subject	NOUN
bptjm-23	187	13	with	with	ADP
bptjm-23	187	14	normal	normal	ADJ
bptjm-23	187	15	lung	lung	NOUN
bptjm-23	187	16	function	function	NOUN
bptjm-23	187	17	were	be	AUX
bptjm-23	187	18	identi	identi	X
bptjm-23	187	19	�	�	NOUN
bptjm-23	187	20	ed	ed	NOUN
bptjm-23	187	21	which	which	PRON
bptjm-23	187	22	showed	show	VERB
bptjm-23	187	23	to	to	PART
bptjm-23	187	24	mostly	mostly	ADV
bptjm-23	187	25	target	target	VERB
bptjm-23	187	26	the	the	DET
bptjm-23	187	27	nuclear	nuclear	ADJ
bptjm-23	187	28	lumen	luman	NOUN
bptjm-23	187	29	and	and	CCONJ
bptjm-23	187	30	transcription	transcription	NOUN
bptjm-23	187	31	.	.	PUNCT
bptjm-23	188	1	of	of	ADP
bptjm-23	188	2	the	the	DET
bptjm-23	188	3	12	12	NUM
bptjm-23	188	4	di	di	NOUN
bptjm-23	188	5	�	�	PROPN
bptjm-23	188	6	erentially	erentially	ADV
bptjm-23	188	7	expressed	express	VERB
bptjm-23	188	8	mirnas	mirna	NOUN
bptjm-23	188	9	,	,	PUNCT
bptjm-23	188	10	mir-28	mir-28	PROPN
bptjm-23	188	11	-	-	PUNCT
bptjm-23	188	12	3p	3p	NUM
bptjm-23	188	13	was	be	AUX
bptjm-23	188	14	most	most	ADV
bptjm-23	188	15	signi	signi	ADJ
bptjm-23	188	16	�	�	NOUN
bptjm-23	188	17	cantly	cantly	ADV
bptjm-23	188	18	down	down	ADV
bptjm-23	188	19	-	-	PUNCT
bptjm-23	188	20	regulated	regulate	VERB
bptjm-23	188	21	and	and	CCONJ
bptjm-23	188	22	mir-212	mir-212	NOUN
bptjm-23	188	23	-	-	PUNCT
bptjm-23	188	24	5p	5p	NUM
bptjm-23	188	25	was	be	AUX
bptjm-23	188	26	most	most	ADV
bptjm-23	188	27	signi	signi	ADJ
bptjm-23	188	28	�	�	NOUN
bptjm-23	188	29	cantly	cantly	ADV
bptjm-23	188	30	up	up	ADV
bptjm-23	188	31	-	-	PUNCT
bptjm-23	188	32	regulated	regulate	VERB
bptjm-23	188	33	[	[	X
bptjm-23	188	34	53	53	NUM
bptjm-23	188	35	]	]	PUNCT
bptjm-23	188	36	.	.	PUNCT
bptjm-23	189	1	more	more	ADV
bptjm-23	189	2	recently	recently	ADV
bptjm-23	189	3	,	,	PUNCT
bptjm-23	189	4	a	a	DET
bptjm-23	189	5	study	study	NOUN
bptjm-23	189	6	showed	show	VERB
bptjm-23	189	7	that	that	SCONJ
bptjm-23	189	8	two	two	NUM
bptjm-23	189	9	constructed	construct	VERB
bptjm-23	189	10	mirna	mirna	PROPN
bptjm-23	189	11	-	-	PUNCT
bptjm-23	189	12	mrna	mrna	PROPN
bptjm-23	189	13	pathways	pathway	NOUN
bptjm-23	189	14	;	;	PUNCT
bptjm-23	189	15	mir-126	mir-126	NOUN
bptjm-23	189	16	-	-	PUNCT
bptjm-23	189	17	5p	5p	NUM
bptjm-23	189	18	and	and	CCONJ
bptjm-23	189	19	mir-130	mir-130	NOUN
bptjm-23	189	20	-	-	PUNCT
bptjm-23	189	21	5p	5p	NUM
bptjm-23	189	22	-	-	PUNCT
bptjm-23	189	23	foxo1	foxo1	NOUN
bptjm-23	189	24	could	could	AUX
bptjm-23	189	25	be	be	AUX
bptjm-23	189	26	potential	potential	ADJ
bptjm-23	189	27	biomarkers	biomarker	NOUN
bptjm-23	189	28	for	for	ADP
bptjm-23	189	29	the	the	DET
bptjm-23	189	30	diagnosis	diagnosis	NOUN
bptjm-23	189	31	and	and	CCONJ
bptjm-23	189	32	treatment	treatment	NOUN
bptjm-23	189	33	of	of	ADP
bptjm-23	189	34	copd54	copd54	NOUN
bptjm-23	189	35	.	.	PUNCT
bptjm-23	190	1	this	this	DET
bptjm-23	190	2	year	year	NOUN
bptjm-23	190	3	,	,	PUNCT
bptjm-23	190	4	a	a	DET
bptjm-23	190	5	study	study	NOUN
bptjm-23	190	6	showed	show	VERB
bptjm-23	190	7	that	that	SCONJ
bptjm-23	190	8	mir-126	mir-126	NOUN
bptjm-23	190	9	was	be	AUX
bptjm-23	190	10	higher	high	ADJ
bptjm-23	190	11	in	in	ADP
bptjm-23	190	12	copd	copd	NOUN
bptjm-23	190	13	patients	patient	NOUN
bptjm-23	190	14	with	with	ADP
bptjm-23	190	15	acute	acute	ADJ
bptjm-23	190	16	exacerbation	exacerbation	NOUN
bptjm-23	190	17	compared	compare	VERB
bptjm-23	190	18	to	to	ADP
bptjm-23	190	19	stable	stable	ADJ
bptjm-23	190	20	copd	copd	NOUN
bptjm-23	190	21	patients	patient	NOUN
bptjm-23	190	22	and	and	CCONJ
bptjm-23	190	23	healthy	healthy	ADJ
bptjm-23	190	24	non	non	ADJ
bptjm-23	190	25	-	-	ADJ
bptjm-23	190	26	copd	copd	ADJ
bptjm-23	190	27	patients	patient	NOUN
bptjm-23	190	28	and	and	CCONJ
bptjm-23	190	29	distinguished	distinguish	VERB
bptjm-23	190	30	the	the	DET
bptjm-23	190	31	groups	group	NOUN
bptjm-23	190	32	.	.	PUNCT
bptjm-23	191	1	this	this	PRON
bptjm-23	191	2	led	lead	VERB
bptjm-23	191	3	to	to	ADP
bptjm-23	191	4	the	the	DET
bptjm-23	191	5	conclusion	conclusion	NOUN
bptjm-23	191	6	that	that	SCONJ
bptjm-23	191	7	the	the	DET
bptjm-23	191	8	dysregulation	dysregulation	NOUN
bptjm-23	191	9	of	of	ADP
bptjm-23	191	10	mir-126	mir-126	NOUN
bptjm-23	191	11	relates	relate	VERB
bptjm-23	191	12	to	to	PART
bptjm-23	191	13	copd	copd	VERB
bptjm-23	191	14	susceptibility	susceptibility	NOUN
bptjm-23	191	15	and	and	CCONJ
bptjm-23	191	16	acute	acute	ADJ
bptjm-23	191	17	exacerbation	exacerbation	NOUN
bptjm-23	191	18	risk	risk	NOUN
bptjm-23	191	19	,	,	PUNCT
bptjm-23	191	20	but	but	CCONJ
bptjm-23	191	21	also	also	ADV
bptjm-23	191	22	is	be	AUX
bptjm-23	191	23	linked	link	VERB
bptjm-23	191	24	to	to	ADP
bptjm-23	191	25	severity	severity	NOUN
bptjm-23	191	26	and	and	CCONJ
bptjm-23	191	27	in	in	ADP
bptjm-23	191	28	�	�	NOUN
bptjm-23	191	29	ammatory	ammatory	ADJ
bptjm-23	191	30	cytokines	cytokine	NOUN
bptjm-23	191	31	in	in	ADP
bptjm-23	191	32	copd	copd	NOUN
bptjm-23	191	33	patients55	patients55	NOUN
bptjm-23	191	34	.	.	PUNCT
bptjm-23	192	1	berkeley	berkeley	PROPN
bptjm-23	192	2	pharma	pharma	PROPN
bptjm-23	192	3	tech	tech	PROPN
bptjm-23	192	4	journal	journal	NOUN
bptjm-23	192	5	of	of	ADP
bptjm-23	192	6	medicine	medicine	NOUN
bptjm-23	193	1	|	|	ADV
bptjm-23	193	2	73	73	NUM
bptjm-23	193	3	discussion	discussion	NOUN
bptjm-23	193	4	chronic	chronic	ADJ
bptjm-23	193	5	obstructive	obstructive	ADJ
bptjm-23	193	6	pulmonary	pulmonary	NOUN
bptjm-23	193	7	disease	disease	NOUN
bptjm-23	193	8	provides	provide	VERB
bptjm-23	193	9	unique	unique	ADJ
bptjm-23	193	10	grounds	ground	NOUN
bptjm-23	193	11	for	for	ADP
bptjm-23	193	12	exploration	exploration	NOUN
bptjm-23	193	13	in	in	ADP
bptjm-23	193	14	new	new	ADJ
bptjm-23	193	15	therapies	therapy	NOUN
bptjm-23	193	16	.	.	PUNCT
bptjm-23	194	1	the	the	DET
bptjm-23	194	2	compounding	compound	VERB
bptjm-23	194	3	factors	factor	NOUN
bptjm-23	194	4	of	of	ADP
bptjm-23	194	5	several	several	ADJ
bptjm-23	194	6	potential	potential	ADJ
bptjm-23	194	7	diseases	disease	NOUN
bptjm-23	194	8	or	or	CCONJ
bptjm-23	194	9	developmental	developmental	ADJ
bptjm-23	194	10	miscues	miscue	NOUN
bptjm-23	194	11	on	on	ADP
bptjm-23	194	12	a	a	DET
bptjm-23	194	13	cellular	cellular	ADJ
bptjm-23	194	14	level	level	NOUN
bptjm-23	194	15	and	and	CCONJ
bptjm-23	194	16	beyond	beyond	ADP
bptjm-23	194	17	make	make	VERB
bptjm-23	194	18	it	it	PRON
bptjm-23	194	19	an	an	DET
bptjm-23	194	20	issue	issue	NOUN
bptjm-23	194	21	to	to	PART
bptjm-23	194	22	solve	solve	VERB
bptjm-23	194	23	.	.	PUNCT
bptjm-23	195	1	however	however	ADV
bptjm-23	195	2	,	,	PUNCT
bptjm-23	195	3	this	this	PRON
bptjm-23	195	4	promotes	promote	VERB
bptjm-23	195	5	much	much	ADV
bptjm-23	195	6	more	more	ADJ
bptjm-23	195	7	de	de	ADP
bptjm-23	195	8	novo	novo	NOUN
bptjm-23	195	9	methods	method	NOUN
bptjm-23	195	10	and	and	CCONJ
bptjm-23	195	11	research	research	NOUN
bptjm-23	195	12	into	into	ADP
bptjm-23	195	13	the	the	DET
bptjm-23	195	14	usage	usage	NOUN
bptjm-23	195	15	of	of	ADP
bptjm-23	195	16	several	several	ADJ
bptjm-23	195	17	therapeutic	therapeutic	ADJ
bptjm-23	195	18	methods	method	NOUN
bptjm-23	195	19	in	in	ADP
bptjm-23	195	20	hopes	hope	NOUN
bptjm-23	195	21	to	to	PART
bptjm-23	195	22	prevent	prevent	VERB
bptjm-23	195	23	such	such	DET
bptjm-23	195	24	a	a	DET
bptjm-23	195	25	prominent	prominent	ADJ
bptjm-23	195	26	issue	issue	NOUN
bptjm-23	195	27	that	that	SCONJ
bptjm-23	195	28	6.4	6.4	NUM
bptjm-23	195	29	%	%	NOUN
bptjm-23	195	30	of	of	ADP
bptjm-23	195	31	americans	americans	PROPN
bptjm-23	195	32	were	be	AUX
bptjm-23	195	33	diagnosed	diagnose	VERB
bptjm-23	195	34	with	with	ADP
bptjm-23	195	35	it	it	PRON
bptjm-23	195	36	in	in	ADP
bptjm-23	195	37	2018	2018	NUM
bptjm-23	195	38	.	.	PUNCT
bptjm-23	196	1	focus	focus	VERB
bptjm-23	196	2	on	on	ADP
bptjm-23	196	3	lung	lung	NOUN
bptjm-23	196	4	tissue	tissue	NOUN
bptjm-23	196	5	dynamics	dynamic	NOUN
bptjm-23	196	6	and	and	CCONJ
bptjm-23	196	7	genetic	genetic	ADJ
bptjm-23	196	8	development	development	NOUN
bptjm-23	196	9	can	can	AUX
bptjm-23	196	10	be	be	AUX
bptjm-23	196	11	accomplished	accomplish	VERB
bptjm-23	196	12	in	in	ADP
bptjm-23	196	13	a	a	DET
bptjm-23	196	14	number	number	NOUN
bptjm-23	196	15	of	of	ADP
bptjm-23	196	16	ways	way	NOUN
bptjm-23	196	17	through	through	ADP
bptjm-23	196	18	gene	gene	NOUN
bptjm-23	196	19	therapy	therapy	NOUN
bptjm-23	196	20	is	be	AUX
bptjm-23	196	21	one	one	NUM
bptjm-23	196	22	of	of	ADP
bptjm-23	196	23	the	the	DET
bptjm-23	196	24	most	most	ADV
bptjm-23	196	25	promising	promising	ADJ
bptjm-23	196	26	and	and	CCONJ
bptjm-23	196	27	has	have	VERB
bptjm-23	196	28	great	great	ADJ
bptjm-23	196	29	potential	potential	NOUN
bptjm-23	196	30	in	in	ADP
bptjm-23	196	31	future	future	ADJ
bptjm-23	196	32	endeavors[jg5	endeavors[jg5	X
bptjm-23	196	33	]	]	PUNCT
bptjm-23	196	34	.	.	PUNCT
bptjm-23	197	1	as	as	ADP
bptjm-23	197	2	an	an	DET
bptjm-23	197	3	overarching	overarching	ADJ
bptjm-23	197	4	�	�	NOUN
bptjm-23	197	5	eld	eld	NOUN
bptjm-23	197	6	,	,	PUNCT
bptjm-23	197	7	gene	gene	NOUN
bptjm-23	197	8	therapy	therapy	NOUN
bptjm-23	197	9	is	be	AUX
bptjm-23	197	10	on	on	ADP
bptjm-23	197	11	the	the	DET
bptjm-23	197	12	forefront	forefront	NOUN
bptjm-23	197	13	of	of	ADP
bptjm-23	197	14	pulmonary	pulmonary	ADJ
bptjm-23	197	15	medicine	medicine	NOUN
bptjm-23	197	16	given	give	VERB
bptjm-23	197	17	its	its	PRON
bptjm-23	197	18	success	success	NOUN
bptjm-23	197	19	in	in	ADP
bptjm-23	197	20	diagnosis	diagnosis	NOUN
bptjm-23	197	21	,	,	PUNCT
bptjm-23	197	22	treatment	treatment	NOUN
bptjm-23	197	23	,	,	PUNCT
bptjm-23	197	24	and	and	CCONJ
bptjm-23	197	25	identi	identi	NOUN
bptjm-23	197	26	�	�	NOUN
bptjm-23	197	27	cation	cation	NOUN
bptjm-23	197	28	in	in	ADP
bptjm-23	197	29	epidemiology	epidemiology	NOUN
bptjm-23	197	30	of	of	ADP
bptjm-23	197	31	cystic	cystic	ADJ
bptjm-23	197	32	�	�	NOUN
bptjm-23	197	33	brosis	brosis	NOUN
bptjm-23	197	34	,	,	PUNCT
bptjm-23	197	35	emphysema	emphysema	NOUN
bptjm-23	197	36	,	,	PUNCT
bptjm-23	197	37	and	and	CCONJ
bptjm-23	197	38	other	other	ADJ
bptjm-23	197	39	common	common	ADJ
bptjm-23	197	40	issues	issue	NOUN
bptjm-23	197	41	which	which	PRON
bptjm-23	197	42	all	all	DET
bptjm-23	197	43	act	act	VERB
bptjm-23	197	44	as	as	ADP
bptjm-23	197	45	compounding	compound	VERB
bptjm-23	197	46	factors	factor	NOUN
bptjm-23	197	47	categorized	categorize	VERB
bptjm-23	197	48	as	as	ADP
bptjm-23	197	49	copd5	copd5	NOUN
bptjm-23	197	50	-	-	SYM
bptjm-23	197	51	9	9	NUM
bptjm-23	197	52	.	.	PUNCT
bptjm-23	197	53	gene	gene	NOUN
bptjm-23	197	54	therapy	therapy	NOUN
bptjm-23	197	55	works	work	VERB
bptjm-23	197	56	as	as	ADP
bptjm-23	197	57	a	a	DET
bptjm-23	197	58	two	two	NUM
bptjm-23	197	59	pronged	pronged	ADJ
bptjm-23	197	60	tool	tool	NOUN
bptjm-23	197	61	in	in	ADP
bptjm-23	197	62	lung	lung	NOUN
bptjm-23	197	63	therapy	therapy	NOUN
bptjm-23	197	64	given	give	VERB
bptjm-23	197	65	the	the	DET
bptjm-23	197	66	vast	vast	ADJ
bptjm-23	197	67	possibilities	possibility	NOUN
bptjm-23	197	68	in	in	ADP
bptjm-23	197	69	the	the	DET
bptjm-23	197	70	�	�	PROPN
bptjm-23	197	71	eld	eld	NOUN
bptjm-23	197	72	between	between	ADP
bptjm-23	197	73	the	the	DET
bptjm-23	197	74	potential	potential	ADJ
bptjm-23	197	75	delivery	delivery	NOUN
bptjm-23	197	76	methods	method	NOUN
bptjm-23	197	77	and	and	CCONJ
bptjm-23	197	78	actual	actual	ADJ
bptjm-23	197	79	genetic	genetic	ADJ
bptjm-23	197	80	and	and	CCONJ
bptjm-23	197	81	cellular	cellular	ADJ
bptjm-23	197	82	targets	target	NOUN
bptjm-23	197	83	.	.	PUNCT
bptjm-23	198	1	the	the	DET
bptjm-23	198	2	combination	combination	NOUN
bptjm-23	198	3	e	e	X
bptjm-23	198	4	�	�	NOUN
bptjm-23	198	5	ect	ect	VERB
bptjm-23	198	6	of	of	ADP
bptjm-23	198	7	these	these	DET
bptjm-23	198	8	two	two	NUM
bptjm-23	198	9	issues	issue	NOUN
bptjm-23	198	10	leads	lead	VERB
bptjm-23	198	11	to	to	ADP
bptjm-23	198	12	near	near	ADP
bptjm-23	198	13	endless	endless	ADJ
bptjm-23	198	14	possibilities	possibility	NOUN
bptjm-23	198	15	in	in	ADP
bptjm-23	198	16	potential	potential	ADJ
bptjm-23	198	17	layouts	layout	NOUN
bptjm-23	198	18	for	for	ADP
bptjm-23	198	19	therapeutic	therapeutic	ADJ
bptjm-23	198	20	strategies	strategy	NOUN
bptjm-23	198	21	.	.	PUNCT
bptjm-23	199	1	in	in	ADP
bptjm-23	199	2	non	non	ADJ
bptjm-23	199	3	-	-	ADJ
bptjm-23	199	4	viral	viral	ADJ
bptjm-23	199	5	delivery	delivery	NOUN
bptjm-23	199	6	methods	method	NOUN
bptjm-23	199	7	,	,	PUNCT
bptjm-23	199	8	liposomes	liposome	NOUN
bptjm-23	199	9	,	,	PUNCT
bptjm-23	199	10	nanoparticles	nanoparticle	NOUN
bptjm-23	199	11	,	,	PUNCT
bptjm-23	199	12	and	and	CCONJ
bptjm-23	199	13	electroporation	electroporation	NOUN
bptjm-23	199	14	are	be	AUX
bptjm-23	199	15	the	the	DET
bptjm-23	199	16	more	more	ADV
bptjm-23	199	17	heavily	heavily	ADV
bptjm-23	199	18	researched	research	VERB
bptjm-23	199	19	aspects	aspect	NOUN
bptjm-23	199	20	and	and	CCONJ
bptjm-23	199	21	provide	provide	VERB
bptjm-23	199	22	a	a	DET
bptjm-23	199	23	basis	basis	NOUN
bptjm-23	199	24	for	for	ADP
bptjm-23	199	25	most	most	ADJ
bptjm-23	199	26	clinical	clinical	ADJ
bptjm-23	199	27	studies1,3,15	studies1,3,15	NOUN
bptjm-23	199	28	.	.	PUNCT
bptjm-23	199	29	liposome	liposome	PROPN
bptjm-23	199	30	based	base	VERB
bptjm-23	199	31	approaches	approach	NOUN
bptjm-23	199	32	and	and	CCONJ
bptjm-23	199	33	many	many	ADJ
bptjm-23	199	34	potential	potential	ADJ
bptjm-23	199	35	nanoparticles	nanoparticle	NOUN
bptjm-23	199	36	limit	limit	VERB
bptjm-23	199	37	immune	immune	ADJ
bptjm-23	199	38	response	response	NOUN
bptjm-23	199	39	thanks	thank	NOUN
bptjm-23	199	40	to	to	ADP
bptjm-23	199	41	their	their	PRON
bptjm-23	199	42	endogenous	endogenous	ADJ
bptjm-23	199	43	nature	nature	NOUN
bptjm-23	199	44	and	and	CCONJ
bptjm-23	199	45	customizable	customizable	ADJ
bptjm-23	199	46	size	size	NOUN
bptjm-23	199	47	to	to	ADP
bptjm-23	199	48	desired	desire	VERB
bptjm-23	199	49	scale	scale	NOUN
bptjm-23	199	50	yet	yet	CCONJ
bptjm-23	199	51	the	the	DET
bptjm-23	199	52	key	key	ADJ
bptjm-23	199	53	di	di	NOUN
bptjm-23	199	54	�	�	PROPN
bptjm-23	199	55	erence	erence	NOUN
bptjm-23	199	56	comes	come	VERB
bptjm-23	199	57	when	when	SCONJ
bptjm-23	199	58	one	one	PRON
bptjm-23	199	59	looks	look	VERB
bptjm-23	199	60	at	at	ADP
bptjm-23	199	61	the	the	DET
bptjm-23	199	62	e	e	NOUN
bptjm-23	199	63	�	�	NOUN
bptjm-23	199	64	ciency	ciency	NOUN
bptjm-23	199	65	.	.	PUNCT
bptjm-23	200	1	liposomes	liposome	NOUN
bptjm-23	200	2	and	and	CCONJ
bptjm-23	200	3	liposomal	liposomal	PROPN
bptjm-23	200	4	nps	nps	PROPN
bptjm-23	200	5	sacri	sacri	PROPN
bptjm-23	200	6	�	�	PROPN
bptjm-23	200	7	ce	ce	PROPN
bptjm-23	200	8	ease	ease	NOUN
bptjm-23	200	9	of	of	ADP
bptjm-23	200	10	use	use	NOUN
bptjm-23	200	11	and	and	CCONJ
bptjm-23	200	12	optimal	optimal	ADJ
bptjm-23	200	13	immunogenicity	immunogenicity	NOUN
bptjm-23	200	14	for	for	ADP
bptjm-23	200	15	e	e	NOUN
bptjm-23	200	16	�	�	NOUN
bptjm-23	200	17	ciency	ciency	NOUN
bptjm-23	200	18	in	in	ADP
bptjm-23	200	19	many	many	ADJ
bptjm-23	200	20	cases	case	NOUN
bptjm-23	200	21	due	due	ADP
bptjm-23	200	22	to	to	ADP
bptjm-23	200	23	the	the	DET
bptjm-23	200	24	body	body	NOUN
bptjm-23	200	25	naturally	naturally	ADV
bptjm-23	200	26	developing	develop	VERB
bptjm-23	200	27	barriers	barrier	NOUN
bptjm-23	200	28	to	to	ADP
bptjm-23	200	29	them	they	PRON
bptjm-23	200	30	such	such	ADJ
bptjm-23	200	31	as	as	ADP
bptjm-23	200	32	nuclear	nuclear	ADJ
bptjm-23	200	33	transport	transport	NOUN
bptjm-23	200	34	of	of	ADP
bptjm-23	200	35	their	their	PRON
bptjm-23	200	36	genetic	genetic	ADJ
bptjm-23	200	37	material	material	NOUN
bptjm-23	200	38	and	and	CCONJ
bptjm-23	200	39	signi	signi	PROPN
bptjm-23	200	40	�	�	NOUN
bptjm-23	200	41	cant	cant	VERB
bptjm-23	200	42	degradation	degradation	NOUN
bptjm-23	200	43	before	before	SCONJ
bptjm-23	200	44	they	they	PRON
bptjm-23	200	45	can	can	AUX
bptjm-23	200	46	have	have	VERB
bptjm-23	200	47	a	a	DET
bptjm-23	200	48	signi	signi	ADJ
bptjm-23	200	49	�	�	NOUN
bptjm-23	200	50	cant	cant	NOUN
bptjm-23	200	51	e	e	NOUN
bptjm-23	200	52	�	�	NOUN
bptjm-23	200	53	ect	ect	X
bptjm-23	200	54	on	on	ADP
bptjm-23	200	55	the	the	DET
bptjm-23	200	56	target15,17	target15,17	PROPN
bptjm-23	200	57	.	.	PUNCT
bptjm-23	201	1	non	non	ADJ
bptjm-23	201	2	-	-	ADJ
bptjm-23	201	3	liposomal	liposomal	ADJ
bptjm-23	201	4	nps	nps	PROPN
bptjm-23	201	5	are	be	AUX
bptjm-23	201	6	the	the	DET
bptjm-23	201	7	most	most	ADV
bptjm-23	201	8	wideopen	wideopen	ADJ
bptjm-23	201	9	area	area	NOUN
bptjm-23	201	10	of	of	ADP
bptjm-23	201	11	research	research	NOUN
bptjm-23	201	12	given	give	VERB
bptjm-23	201	13	the	the	DET
bptjm-23	201	14	plethora	plethora	NOUN
bptjm-23	201	15	of	of	ADP
bptjm-23	201	16	potential	potential	ADJ
bptjm-23	201	17	formulations	formulation	NOUN
bptjm-23	201	18	.	.	PUNCT
bptjm-23	202	1	plga	plga	NOUN
bptjm-23	202	2	and	and	CCONJ
bptjm-23	202	3	dendrimer	dendrimer	NOUN
bptjm-23	202	4	nanoparticles	nanoparticle	NOUN
bptjm-23	202	5	for	for	ADP
bptjm-23	202	6	lung	lung	NOUN
bptjm-23	202	7	therapy	therapy	NOUN
bptjm-23	202	8	have	have	AUX
bptjm-23	202	9	seen	see	VERB
bptjm-23	202	10	success	success	NOUN
bptjm-23	202	11	given	give	VERB
bptjm-23	202	12	their	their	PRON
bptjm-23	202	13	idealized	idealized	ADJ
bptjm-23	202	14	interaction	interaction	NOUN
bptjm-23	202	15	.	.	PUNCT
bptjm-23	203	1	yet	yet	ADV
bptjm-23	203	2	,	,	PUNCT
bptjm-23	203	3	price	price	NOUN
bptjm-23	203	4	points	point	NOUN
bptjm-23	203	5	become	become	VERB
bptjm-23	203	6	an	an	DET
bptjm-23	203	7	issue	issue	NOUN
bptjm-23	203	8	when	when	SCONJ
bptjm-23	203	9	one	one	PRON
bptjm-23	203	10	looks	look	VERB
bptjm-23	203	11	at	at	ADP
bptjm-23	203	12	the	the	DET
bptjm-23	203	13	extensive	extensive	ADJ
bptjm-23	203	14	research	research	NOUN
bptjm-23	203	15	and	and	CCONJ
bptjm-23	203	16	time	time	NOUN
bptjm-23	203	17	that	that	PRON
bptjm-23	203	18	must	must	AUX
bptjm-23	203	19	be	be	AUX
bptjm-23	203	20	put	put	VERB
bptjm-23	203	21	into	into	ADP
bptjm-23	203	22	each	each	DET
bptjm-23	203	23	individual	individual	ADJ
bptjm-23	203	24	iteration	iteration	NOUN
bptjm-23	203	25	of	of	ADP
bptjm-23	203	26	a	a	DET
bptjm-23	203	27	given	give	VERB
bptjm-23	203	28	treatment	treatment	NOUN
bptjm-23	203	29	method22,30	method22,30	PROPN
bptjm-23	203	30	.	.	PUNCT
bptjm-23	204	1	for	for	ADP
bptjm-23	204	2	example	example	NOUN
bptjm-23	204	3	,	,	PUNCT
bptjm-23	204	4	berkeley	berkeley	PROPN
bptjm-23	204	5	pharma	pharma	PROPN
bptjm-23	204	6	tech	tech	NOUN
bptjm-23	204	7	journal	journal	NOUN
bptjm-23	204	8	of	of	ADP
bptjm-23	204	9	medicine	medicine	NOUN
bptjm-23	204	10	|	|	ADV
bptjm-23	204	11	74	74	NUM
bptjm-23	204	12	taking	take	VERB
bptjm-23	204	13	a	a	DET
bptjm-23	204	14	simple	simple	ADJ
bptjm-23	204	15	plga	plga	NOUN
bptjm-23	204	16	coated	coated	ADJ
bptjm-23	204	17	nanoparticle	nanoparticle	NOUN
bptjm-23	204	18	with	with	ADP
bptjm-23	204	19	targeting	target	VERB
bptjm-23	204	20	sites	site	NOUN
bptjm-23	204	21	to	to	PART
bptjm-23	204	22	deliver	deliver	VERB
bptjm-23	204	23	to	to	ADP
bptjm-23	204	24	lung	lung	NOUN
bptjm-23	204	25	epithelia	epithelium	NOUN
bptjm-23	204	26	for	for	ADP
bptjm-23	204	27	production	production	NOUN
bptjm-23	204	28	in	in	ADP
bptjm-23	204	29	a1at	a1at	PROPN
bptjm-23	204	30	vs.	vs.	ADP
bptjm-23	204	31	the	the	DET
bptjm-23	204	32	exact	exact	ADJ
bptjm-23	204	33	same	same	ADJ
bptjm-23	204	34	base	base	NOUN
bptjm-23	204	35	particle	particle	NOUN
bptjm-23	204	36	complemented	complement	VERB
bptjm-23	204	37	to	to	PART
bptjm-23	204	38	target	target	VERB
bptjm-23	204	39	ciliated	ciliated	ADJ
bptjm-23	204	40	cells	cell	NOUN
bptjm-23	204	41	will	will	AUX
bptjm-23	204	42	require	require	VERB
bptjm-23	204	43	entirely	entirely	ADV
bptjm-23	204	44	di	di	NOUN
bptjm-23	204	45	�	�	PROPN
bptjm-23	204	46	erent	erent	NOUN
bptjm-23	204	47	sets	set	NOUN
bptjm-23	204	48	of	of	ADP
bptjm-23	204	49	trials	trial	NOUN
bptjm-23	204	50	and	and	CCONJ
bptjm-23	204	51	fda	fda	PROPN
bptjm-23	204	52	compliance	compliance	NOUN
bptjm-23	204	53	before	before	SCONJ
bptjm-23	204	54	any	any	DET
bptjm-23	204	55	signi	signi	ADJ
bptjm-23	204	56	�	�	NOUN
bptjm-23	204	57	cant	cant	NOUN
bptjm-23	204	58	levels	level	NOUN
bptjm-23	204	59	of	of	ADP
bptjm-23	204	60	usage	usage	NOUN
bptjm-23	204	61	can	can	AUX
bptjm-23	204	62	occur	occur	VERB
bptjm-23	204	63	.	.	PUNCT
bptjm-23	205	1	this	this	PRON
bptjm-23	205	2	is	be	AUX
bptjm-23	205	3	obviously	obviously	ADV
bptjm-23	205	4	necessary	necessary	ADJ
bptjm-23	205	5	for	for	ADP
bptjm-23	205	6	safety	safety	NOUN
bptjm-23	205	7	and	and	CCONJ
bptjm-23	205	8	ethical	ethical	ADJ
bptjm-23	205	9	concerns	concern	NOUN
bptjm-23	205	10	but	but	CCONJ
bptjm-23	205	11	presents	present	VERB
bptjm-23	205	12	a	a	DET
bptjm-23	205	13	signi	signi	ADJ
bptjm-23	205	14	�	�	NOUN
bptjm-23	205	15	cant	cant	NOUN
bptjm-23	205	16	holdup	holdup	NOUN
bptjm-23	205	17	in	in	ADP
bptjm-23	205	18	advancement	advancement	NOUN
bptjm-23	205	19	of	of	ADP
bptjm-23	205	20	np	np	PRON
bptjm-23	205	21	as	as	ADP
bptjm-23	205	22	a	a	DET
bptjm-23	205	23	therapy	therapy	NOUN
bptjm-23	205	24	for	for	ADP
bptjm-23	205	25	copd	copd	NOUN
bptjm-23	205	26	.	.	PUNCT
bptjm-23	206	1	electroporation	electroporation	NOUN
bptjm-23	206	2	uses	use	VERB
bptjm-23	206	3	the	the	DET
bptjm-23	206	4	manipulated	manipulate	VERB
bptjm-23	206	5	electric	electric	PROPN
bptjm-23	206	6	�	�	PROPN
bptjm-23	206	7	elds	eld	NOUN
bptjm-23	206	8	in	in	ADP
bptjm-23	206	9	cells	cell	NOUN
bptjm-23	206	10	to	to	PART
bptjm-23	206	11	increase	increase	VERB
bptjm-23	206	12	permeability	permeability	NOUN
bptjm-23	206	13	signi	signi	PROPN
bptjm-23	206	14	�	�	NOUN
bptjm-23	206	15	cantly	cantly	ADV
bptjm-23	206	16	.	.	PUNCT
bptjm-23	207	1	targeting	target	VERB
bptjm-23	207	2	speci	speci	PROPN
bptjm-23	207	3	�	�	PROPN
bptjm-23	207	4	city	city	NOUN
bptjm-23	207	5	and	and	CCONJ
bptjm-23	207	6	overall	overall	ADJ
bptjm-23	207	7	quality	quality	NOUN
bptjm-23	207	8	of	of	ADP
bptjm-23	207	9	research	research	NOUN
bptjm-23	207	10	eludes	elude	VERB
bptjm-23	207	11	the	the	DET
bptjm-23	207	12	�	�	PROPN
bptjm-23	207	13	eld	eld	NOUN
bptjm-23	208	1	but	but	CCONJ
bptjm-23	208	2	it	it	PRON
bptjm-23	208	3	presents	present	VERB
bptjm-23	208	4	a	a	DET
bptjm-23	208	5	purely	purely	ADV
bptjm-23	208	6	physical	physical	ADJ
bptjm-23	208	7	method	method	NOUN
bptjm-23	208	8	for	for	ADP
bptjm-23	208	9	gene	gene	NOUN
bptjm-23	208	10	therapy	therapy	NOUN
bptjm-23	208	11	delivery	delivery	NOUN
bptjm-23	208	12	and	and	CCONJ
bptjm-23	208	13	even	even	ADV
bptjm-23	208	14	assisting	assist	VERB
bptjm-23	208	15	other	other	ADJ
bptjm-23	208	16	methods	method	NOUN
bptjm-23	208	17	should	should	AUX
bptjm-23	208	18	cell	cell	VERB
bptjm-23	208	19	access	access	NOUN
bptjm-23	208	20	present	present	ADJ
bptjm-23	208	21	a	a	DET
bptjm-23	208	22	signi	signi	ADJ
bptjm-23	208	23	�	�	NOUN
bptjm-23	208	24	cant	cant	NOUN
bptjm-23	208	25	issue1,33	issue1,33	PRON
bptjm-23	208	26	.	.	PUNCT
bptjm-23	209	1	viral	viral	ADJ
bptjm-23	209	2	methods	method	NOUN
bptjm-23	209	3	for	for	ADP
bptjm-23	209	4	delivering	deliver	VERB
bptjm-23	209	5	gene	gene	NOUN
bptjm-23	209	6	therapy	therapy	NOUN
bptjm-23	209	7	are	be	AUX
bptjm-23	209	8	composed	compose	VERB
bptjm-23	209	9	of	of	ADP
bptjm-23	209	10	mostly	mostly	ADV
bptjm-23	209	11	adeno	adeno	NOUN
bptjm-23	209	12	and	and	CCONJ
bptjm-23	209	13	adeno	adeno	NOUN
bptjm-23	209	14	-	-	PUNCT
bptjm-23	209	15	associated	associate	VERB
bptjm-23	209	16	viruses	virus	NOUN
bptjm-23	209	17	given	give	VERB
bptjm-23	209	18	the	the	DET
bptjm-23	209	19	broad	broad	ADJ
bptjm-23	209	20	spectrum	spectrum	NOUN
bptjm-23	209	21	they	they	PRON
bptjm-23	209	22	o	o	NOUN
bptjm-23	209	23	�	�	PROPN
bptjm-23	209	24	er	er	INTJ
bptjm-23	209	25	for	for	ADP
bptjm-23	209	26	behavior	behavior	NOUN
bptjm-23	209	27	and	and	CCONJ
bptjm-23	209	28	ease	ease	NOUN
bptjm-23	209	29	of	of	ADP
bptjm-23	209	30	modi	modi	PROPN
bptjm-23	209	31	�	�	PROPN
bptjm-23	209	32	cation35	cation35	PROPN
bptjm-23	209	33	.	.	PUNCT
bptjm-23	210	1	both	both	DET
bptjm-23	210	2	o	o	X
bptjm-23	210	3	�	�	PROPN
bptjm-23	210	4	er	er	NOUN
bptjm-23	210	5	one	one	NUM
bptjm-23	210	6	of	of	ADP
bptjm-23	210	7	the	the	DET
bptjm-23	210	8	more	more	ADV
bptjm-23	210	9	sought	seek	VERB
bptjm-23	210	10	after	after	ADP
bptjm-23	210	11	qualities	quality	NOUN
bptjm-23	210	12	in	in	ADP
bptjm-23	210	13	gene	gene	NOUN
bptjm-23	210	14	therapy	therapy	NOUN
bptjm-23	210	15	strategies	strategy	NOUN
bptjm-23	210	16	in	in	ADP
bptjm-23	210	17	their	their	PRON
bptjm-23	210	18	integration	integration	NOUN
bptjm-23	210	19	abilities	ability	NOUN
bptjm-23	210	20	.	.	PUNCT
bptjm-23	211	1	the	the	DET
bptjm-23	211	2	inherent	inherent	ADJ
bptjm-23	211	3	function	function	NOUN
bptjm-23	211	4	of	of	ADP
bptjm-23	211	5	viruses	virus	NOUN
bptjm-23	211	6	makes	make	VERB
bptjm-23	211	7	them	they	PRON
bptjm-23	211	8	ideal	ideal	ADJ
bptjm-23	211	9	vectors	vector	NOUN
bptjm-23	211	10	that	that	PRON
bptjm-23	211	11	just	just	ADV
bptjm-23	211	12	need	need	VERB
bptjm-23	211	13	to	to	PART
bptjm-23	211	14	be	be	AUX
bptjm-23	211	15	altered	alter	VERB
bptjm-23	211	16	for	for	ADP
bptjm-23	211	17	the	the	DET
bptjm-23	211	18	desired	desire	VERB
bptjm-23	211	19	function	function	NOUN
bptjm-23	211	20	.	.	PUNCT
bptjm-23	212	1	immune	immune	ADJ
bptjm-23	212	2	response	response	NOUN
bptjm-23	212	3	is	be	AUX
bptjm-23	212	4	an	an	DET
bptjm-23	212	5	issue	issue	NOUN
bptjm-23	212	6	that	that	PRON
bptjm-23	212	7	can	can	AUX
bptjm-23	212	8	be	be	AUX
bptjm-23	212	9	improved	improve	VERB
bptjm-23	212	10	upon	upon	SCONJ
bptjm-23	212	11	but	but	CCONJ
bptjm-23	212	12	presents	present	VERB
bptjm-23	212	13	one	one	NUM
bptjm-23	212	14	of	of	ADP
bptjm-23	212	15	the	the	DET
bptjm-23	212	16	only	only	ADJ
bptjm-23	212	17	signi	signi	PROPN
bptjm-23	212	18	�	�	NOUN
bptjm-23	212	19	cant	cant	VERB
bptjm-23	212	20	issues	issue	NOUN
bptjm-23	212	21	in	in	ADP
bptjm-23	212	22	their	their	PRON
bptjm-23	212	23	usage	usage	NOUN
bptjm-23	212	24	as	as	ADP
bptjm-23	212	25	gene	gene	NOUN
bptjm-23	212	26	vectors44	vectors44	NOUN
bptjm-23	212	27	.	.	PUNCT
bptjm-23	213	1	targets	target	NOUN
bptjm-23	213	2	for	for	ADP
bptjm-23	213	3	the	the	DET
bptjm-23	213	4	readily	readily	ADV
bptjm-23	213	5	available	available	ADJ
bptjm-23	213	6	delivery	delivery	NOUN
bptjm-23	213	7	methods	method	NOUN
bptjm-23	213	8	is	be	AUX
bptjm-23	213	9	where	where	SCONJ
bptjm-23	213	10	the	the	DET
bptjm-23	213	11	speci	speci	PROPN
bptjm-23	213	12	�	�	PROPN
bptjm-23	213	13	city	city	NOUN
bptjm-23	213	14	of	of	ADP
bptjm-23	213	15	copd	copd	PROPN
bptjm-23	213	16	comes	come	VERB
bptjm-23	213	17	to	to	ADP
bptjm-23	213	18	the	the	DET
bptjm-23	213	19	forefront	forefront	NOUN
bptjm-23	213	20	of	of	ADP
bptjm-23	213	21	treatment	treatment	NOUN
bptjm-23	213	22	.	.	PUNCT
bptjm-23	214	1	inhalable	inhalable	ADJ
bptjm-23	214	2	therapies	therapy	NOUN
bptjm-23	214	3	provide	provide	VERB
bptjm-23	214	4	a	a	DET
bptjm-23	214	5	unique	unique	ADJ
bptjm-23	214	6	avenue	avenue	NOUN
bptjm-23	214	7	for	for	ADP
bptjm-23	214	8	treating	treat	VERB
bptjm-23	214	9	pulmonary	pulmonary	ADJ
bptjm-23	214	10	issues	issue	NOUN
bptjm-23	214	11	that	that	PRON
bptjm-23	214	12	might	might	AUX
bptjm-23	214	13	not	not	PART
bptjm-23	214	14	be	be	AUX
bptjm-23	214	15	possible	possible	ADJ
bptjm-23	214	16	with	with	ADP
bptjm-23	214	17	other	other	ADJ
bptjm-23	214	18	groups	group	NOUN
bptjm-23	214	19	of	of	ADP
bptjm-23	214	20	diseases	disease	NOUN
bptjm-23	214	21	,	,	PUNCT
bptjm-23	214	22	thus	thus	ADV
bptjm-23	214	23	it	it	PRON
bptjm-23	214	24	has	have	AUX
bptjm-23	214	25	been	be	AUX
bptjm-23	214	26	explored	explore	VERB
bptjm-23	214	27	heavily	heavily	ADV
bptjm-23	214	28	with	with	ADP
bptjm-23	214	29	iterations	iteration	NOUN
bptjm-23	214	30	of	of	ADP
bptjm-23	214	31	liposomal	liposomal	ADJ
bptjm-23	214	32	np	np	PROPN
bptjm-23	214	33	and	and	CCONJ
bptjm-23	214	34	viral	viral	ADJ
bptjm-23	214	35	vector	vector	NOUN
bptjm-23	214	36	bodies	body	NOUN
bptjm-23	214	37	optimized	optimize	VERB
bptjm-23	214	38	for	for	ADP
bptjm-23	214	39	breaking	break	VERB
bptjm-23	214	40	through	through	ADP
bptjm-23	214	41	the	the	DET
bptjm-23	214	42	heavy	heavy	ADJ
bptjm-23	214	43	mucus	mucus	NOUN
bptjm-23	214	44	and	and	CCONJ
bptjm-23	214	45	surfactant	surfactant	ADJ
bptjm-23	214	46	layers	layer	NOUN
bptjm-23	214	47	in	in	ADP
bptjm-23	214	48	lung	lung	NOUN
bptjm-23	214	49	tissues17,42	tissues17,42	PROPN
bptjm-23	214	50	-	-	NOUN
bptjm-23	214	51	43,48	43,48	NOUN
bptjm-23	214	52	.	.	PUNCT
bptjm-23	215	1	a	a	DET
bptjm-23	215	2	variety	variety	NOUN
bptjm-23	215	3	of	of	ADP
bptjm-23	215	4	cells	cell	NOUN
bptjm-23	215	5	are	be	AUX
bptjm-23	215	6	still	still	ADV
bptjm-23	215	7	accessible	accessible	ADJ
bptjm-23	215	8	through	through	ADP
bptjm-23	215	9	this	this	DET
bptjm-23	215	10	minimally	minimally	ADV
bptjm-23	215	11	invasive	invasive	ADJ
bptjm-23	215	12	gene	gene	NOUN
bptjm-23	215	13	therapy26	therapy26	NOUN
bptjm-23	215	14	.	.	PUNCT
bptjm-23	216	1	new	new	ADJ
bptjm-23	216	2	stem	stem	NOUN
bptjm-23	216	3	cell	cell	NOUN
bptjm-23	216	4	therapy	therapy	NOUN
bptjm-23	216	5	for	for	ADP
bptjm-23	216	6	copd	copd	NOUN
bptjm-23	216	7	focus	focus	VERB
bptjm-23	216	8	primarily	primarily	ADV
bptjm-23	216	9	on	on	ADP
bptjm-23	216	10	mesenchymal	mesenchymal	ADJ
bptjm-23	216	11	stem	stem	NOUN
bptjm-23	216	12	cells	cell	NOUN
bptjm-23	216	13	given	give	VERB
bptjm-23	216	14	their	their	PRON
bptjm-23	216	15	limited	limited	ADJ
bptjm-23	216	16	exhibition	exhibition	NOUN
bptjm-23	216	17	of	of	ADP
bptjm-23	216	18	pluripotent	pluripotent	ADJ
bptjm-23	216	19	properties	property	NOUN
bptjm-23	216	20	.	.	PUNCT
bptjm-23	217	1	one	one	NUM
bptjm-23	217	2	of	of	ADP
bptjm-23	217	3	the	the	DET
bptjm-23	217	4	most	most	ADV
bptjm-23	217	5	well	well	ADV
bptjm-23	217	6	researched	research	VERB
bptjm-23	217	7	causes	cause	NOUN
bptjm-23	217	8	and	and	CCONJ
bptjm-23	217	9	potential	potential	ADJ
bptjm-23	217	10	targets	target	NOUN
bptjm-23	217	11	for	for	ADP
bptjm-23	217	12	copd	copd	NOUN
bptjm-23	217	13	is	be	AUX
bptjm-23	217	14	that	that	PRON
bptjm-23	217	15	of	of	ADP
bptjm-23	217	16	a1at	a1at	PUNCT
bptjm-23	217	17	where	where	SCONJ
bptjm-23	217	18	gene	gene	NOUN
bptjm-23	217	19	alteration	alteration	NOUN
bptjm-23	217	20	to	to	ADP
bptjm-23	217	21	the	the	DET
bptjm-23	217	22	common	common	ADJ
bptjm-23	217	23	zz	zz	PROPN
bptjm-23	217	24	mutation	mutation	NOUN
bptjm-23	217	25	or	or	CCONJ
bptjm-23	217	26	to	to	PART
bptjm-23	217	27	improve	improve	VERB
bptjm-23	217	28	production	production	NOUN
bptjm-23	217	29	in	in	ADP
bptjm-23	217	30	a1at	a1at	X
bptjm-23	217	31	de	de	PROPN
bptjm-23	217	32	�	�	PROPN
bptjm-23	217	33	cient	cient	NOUN
bptjm-23	217	34	individuals	individual	NOUN
bptjm-23	217	35	has	have	AUX
bptjm-23	217	36	been	be	AUX
bptjm-23	217	37	seen	see	VERB
bptjm-23	217	38	to	to	PART
bptjm-23	217	39	improve	improve	VERB
bptjm-23	217	40	both	both	DET
bptjm-23	217	41	physiological	physiological	ADJ
bptjm-23	217	42	qualities	quality	NOUN
bptjm-23	217	43	and	and	CCONJ
bptjm-23	217	44	provided	provide	VERB
bptjm-23	217	45	long	long	ADJ
bptjm-23	217	46	term	term	NOUN
bptjm-23	217	47	expression50	expression50	NOUN
bptjm-23	217	48	-	-	PUNCT
bptjm-23	217	49	52	52	NUM
bptjm-23	217	50	.	.	PUNCT
bptjm-23	218	1	the	the	DET
bptjm-23	218	2	�	�	NOUN
bptjm-23	218	3	nal	nal	NOUN
bptjm-23	218	4	but	but	CCONJ
bptjm-23	218	5	potentially	potentially	ADV
bptjm-23	218	6	most	most	ADV
bptjm-23	218	7	broad	broad	ADJ
bptjm-23	218	8	method	method	NOUN
bptjm-23	218	9	for	for	ADP
bptjm-23	218	10	focusing	focus	VERB
bptjm-23	218	11	on	on	ADP
bptjm-23	218	12	the	the	DET
bptjm-23	218	13	issues	issue	NOUN
bptjm-23	218	14	presented	present	VERB
bptjm-23	218	15	in	in	ADP
bptjm-23	218	16	copd	copd	PROPN
bptjm-23	218	17	is	be	AUX
bptjm-23	218	18	that	that	PRON
bptjm-23	218	19	of	of	ADP
bptjm-23	218	20	working	work	VERB
bptjm-23	218	21	with	with	ADP
bptjm-23	218	22	mirna	mirna	NOUN
bptjm-23	218	23	using	use	VERB
bptjm-23	218	24	the	the	DET
bptjm-23	218	25	aforementioned	aforementioned	ADJ
bptjm-23	218	26	delivery	delivery	NOUN
bptjm-23	218	27	methods	method	NOUN
bptjm-23	218	28	.	.	PUNCT
bptjm-23	219	1	as	as	ADP
bptjm-23	219	2	a	a	DET
bptjm-23	219	3	primary	primary	ADJ
bptjm-23	219	4	regulator	regulator	NOUN
bptjm-23	219	5	for	for	ADP
bptjm-23	219	6	gene	gene	NOUN
bptjm-23	219	7	expression	expression	NOUN
bptjm-23	219	8	,	,	PUNCT
bptjm-23	219	9	in	in	ADP
bptjm-23	219	10	depth	depth	NOUN
bptjm-23	219	11	studies	study	NOUN
bptjm-23	219	12	have	have	AUX
bptjm-23	219	13	found	find	VERB
bptjm-23	219	14	disparities	disparity	NOUN
bptjm-23	219	15	in	in	ADP
bptjm-23	219	16	mirna	mirna	PROPN
bptjm-23	219	17	quality	quality	NOUN
bptjm-23	219	18	in	in	ADP
bptjm-23	219	19	berkeley	berkeley	PROPN
bptjm-23	219	20	pharma	pharma	PROPN
bptjm-23	219	21	tech	tech	NOUN
bptjm-23	219	22	journal	journal	NOUN
bptjm-23	219	23	of	of	ADP
bptjm-23	219	24	medicine	medicine	NOUN
bptjm-23	220	1	|	|	ADV
bptjm-23	220	2	75	75	NUM
bptjm-23	220	3	copd	copd	NOUN
bptjm-23	220	4	patients53	patients53	NOUN
bptjm-23	220	5	.	.	PUNCT
bptjm-23	221	1	insertion	insertion	NOUN
bptjm-23	221	2	of	of	ADP
bptjm-23	221	3	nps	nps	PROPN
bptjm-23	221	4	to	to	PART
bptjm-23	221	5	change	change	VERB
bptjm-23	221	6	mirna	mirna	NOUN
bptjm-23	221	7	expression	expression	NOUN
bptjm-23	221	8	for	for	ADP
bptjm-23	221	9	issues	issue	NOUN
bptjm-23	221	10	like	like	ADP
bptjm-23	221	11	lung	lung	NOUN
bptjm-23	221	12	irritation	irritation	NOUN
bptjm-23	221	13	have	have	AUX
bptjm-23	221	14	also	also	ADV
bptjm-23	221	15	seen	see	VERB
bptjm-23	221	16	success56	success56	NOUN
bptjm-23	221	17	.	.	PUNCT
bptjm-23	222	1	looking	look	VERB
bptjm-23	222	2	at	at	ADP
bptjm-23	222	3	these	these	DET
bptjm-23	222	4	delivery	delivery	NOUN
bptjm-23	222	5	methods	method	NOUN
bptjm-23	222	6	in	in	ADP
bptjm-23	222	7	tandem	tandem	NOUN
bptjm-23	222	8	with	with	ADP
bptjm-23	222	9	targeting	target	VERB
bptjm-23	222	10	goal	goal	NOUN
bptjm-23	222	11	is	be	AUX
bptjm-23	222	12	the	the	DET
bptjm-23	222	13	only	only	ADJ
bptjm-23	222	14	way	way	NOUN
bptjm-23	222	15	to	to	AUX
bptjm-23	222	16	e	e	NOUN
bptjm-23	222	17	�	�	NOUN
bptjm-23	222	18	ectively	ectively	ADV
bptjm-23	222	19	evaluate	evaluate	VERB
bptjm-23	222	20	the	the	DET
bptjm-23	222	21	viability	viability	NOUN
bptjm-23	222	22	of	of	ADP
bptjm-23	222	23	a	a	DET
bptjm-23	222	24	therapeutic	therapeutic	ADJ
bptjm-23	222	25	strategy	strategy	NOUN
bptjm-23	222	26	for	for	ADP
bptjm-23	222	27	copd	copd	NOUN
bptjm-23	222	28	and	and	CCONJ
bptjm-23	222	29	look	look	VERB
bptjm-23	222	30	to	to	PART
bptjm-23	222	31	improve	improve	VERB
bptjm-23	222	32	the	the	DET
bptjm-23	222	33	current	current	ADJ
bptjm-23	222	34	state	state	NOUN
bptjm-23	222	35	of	of	ADP
bptjm-23	222	36	understanding	understanding	NOUN
bptjm-23	222	37	in	in	ADP
bptjm-23	222	38	treatment	treatment	NOUN
bptjm-23	222	39	for	for	ADP
bptjm-23	222	40	it	it	PRON
bptjm-23	222	41	.	.	PUNCT
bptjm-23	223	1	conclusion	conclusion	NOUN
bptjm-23	223	2	although	although	SCONJ
bptjm-23	223	3	there	there	PRON
bptjm-23	223	4	are	be	VERB
bptjm-23	223	5	many	many	ADJ
bptjm-23	223	6	potential	potential	ADJ
bptjm-23	223	7	treatment	treatment	NOUN
bptjm-23	223	8	avenues	avenue	NOUN
bptjm-23	223	9	,	,	PUNCT
bptjm-23	223	10	there	there	PRON
bptjm-23	223	11	needs	need	VERB
bptjm-23	223	12	to	to	PART
bptjm-23	223	13	be	be	AUX
bptjm-23	223	14	a	a	DET
bptjm-23	223	15	large	large	ADJ
bptjm-23	223	16	focus	focus	NOUN
bptjm-23	223	17	on	on	ADP
bptjm-23	223	18	personalized	personalized	ADJ
bptjm-23	223	19	medicine	medicine	NOUN
bptjm-23	223	20	as	as	ADP
bptjm-23	223	21	the	the	DET
bptjm-23	223	22	source	source	NOUN
bptjm-23	223	23	of	of	ADP
bptjm-23	223	24	patients	patient	NOUN
bptjm-23	223	25	’	'	PUNCT
bptjm-23	223	26	copd	copd	PROPN
bptjm-23	223	27	can	can	AUX
bptjm-23	223	28	vary	vary	VERB
bptjm-23	223	29	.	.	PUNCT
bptjm-23	224	1	severity	severity	NOUN
bptjm-23	224	2	and	and	CCONJ
bptjm-23	224	3	associated	associated	ADJ
bptjm-23	224	4	symptoms	symptom	NOUN
bptjm-23	224	5	are	be	AUX
bptjm-23	224	6	plentiful	plentiful	ADJ
bptjm-23	224	7	in	in	ADP
bptjm-23	224	8	copd	copd	NOUN
bptjm-23	224	9	which	which	PRON
bptjm-23	224	10	only	only	ADV
bptjm-23	224	11	serves	serve	VERB
bptjm-23	224	12	to	to	ADP
bptjm-23	224	13	necessitate	necessitate	ADJ
bptjm-23	224	14	more	more	ADJ
bptjm-23	224	15	research	research	NOUN
bptjm-23	224	16	into	into	ADP
bptjm-23	224	17	the	the	DET
bptjm-23	224	18	�	�	PROPN
bptjm-23	224	19	eld	eld	NOUN
bptjm-23	224	20	.	.	PUNCT
bptjm-23	225	1	making	make	VERB
bptjm-23	225	2	strides	stride	NOUN
bptjm-23	225	3	towards	towards	ADP
bptjm-23	225	4	being	be	AUX
bptjm-23	225	5	able	able	ADJ
bptjm-23	225	6	to	to	PART
bptjm-23	225	7	identify	identify	VERB
bptjm-23	225	8	the	the	DET
bptjm-23	225	9	best	well	ADV
bptjm-23	225	10	suited	suited	ADJ
bptjm-23	225	11	treatment	treatment	NOUN
bptjm-23	225	12	for	for	ADP
bptjm-23	225	13	an	an	DET
bptjm-23	225	14	individual	individual	NOUN
bptjm-23	225	15	will	will	AUX
bptjm-23	225	16	result	result	VERB
bptjm-23	225	17	in	in	ADP
bptjm-23	225	18	the	the	DET
bptjm-23	225	19	most	most	ADJ
bptjm-23	225	20	e	e	NOUN
bptjm-23	225	21	�	�	NOUN
bptjm-23	225	22	ective	ective	ADJ
bptjm-23	225	23	outcomes	outcome	NOUN
bptjm-23	225	24	and	and	CCONJ
bptjm-23	225	25	treatments	treatment	NOUN
bptjm-23	225	26	.	.	PUNCT
bptjm-23	226	1	the	the	DET
bptjm-23	226	2	demonstration	demonstration	NOUN
bptjm-23	226	3	of	of	ADP
bptjm-23	226	4	e	e	PROPN
bptjm-23	226	5	�	�	NOUN
bptjm-23	226	6	ectiveness	ectiveness	NOUN
bptjm-23	226	7	in	in	ADP
bptjm-23	226	8	both	both	DET
bptjm-23	226	9	speci	speci	PROPN
bptjm-23	226	10	�	�	PROPN
bptjm-23	226	11	c	c	NOUN
bptjm-23	226	12	cell	cell	NOUN
bptjm-23	226	13	targets	target	NOUN
bptjm-23	226	14	in	in	ADP
bptjm-23	226	15	vitro	vitro	X
bptjm-23	226	16	as	as	ADV
bptjm-23	226	17	well	well	ADV
bptjm-23	226	18	as	as	ADP
bptjm-23	226	19	delivery	delivery	NOUN
bptjm-23	226	20	methods	method	NOUN
bptjm-23	226	21	must	must	AUX
bptjm-23	226	22	come	come	VERB
bptjm-23	226	23	together	together	ADV
bptjm-23	226	24	to	to	PART
bptjm-23	226	25	formulate	formulate	VERB
bptjm-23	226	26	idealized	idealized	ADJ
bptjm-23	226	27	gene	gene	NOUN
bptjm-23	226	28	therapy	therapy	NOUN
bptjm-23	226	29	treatments	treatment	NOUN
bptjm-23	226	30	.	.	PUNCT
bptjm-23	227	1	issues	issue	NOUN
bptjm-23	227	2	present	present	VERB
bptjm-23	227	3	themselves	themselves	PRON
bptjm-23	227	4	in	in	ADP
bptjm-23	227	5	all	all	DET
bptjm-23	227	6	areas	area	NOUN
bptjm-23	227	7	discussed	discuss	VERB
bptjm-23	227	8	though	though	SCONJ
bptjm-23	227	9	they	they	PRON
bptjm-23	227	10	remain	remain	VERB
bptjm-23	227	11	the	the	DET
bptjm-23	227	12	primary	primary	ADJ
bptjm-23	227	13	modes	mode	NOUN
bptjm-23	227	14	of	of	ADP
bptjm-23	227	15	treatment	treatment	NOUN
bptjm-23	227	16	in	in	ADP
bptjm-23	227	17	modern	modern	ADJ
bptjm-23	227	18	medicine	medicine	NOUN
bptjm-23	227	19	.	.	PUNCT
bptjm-23	228	1	understanding	understand	VERB
bptjm-23	228	2	the	the	DET
bptjm-23	228	3	subject	subject	NOUN
bptjm-23	228	4	and	and	CCONJ
bptjm-23	228	5	dynamics	dynamic	NOUN
bptjm-23	228	6	of	of	ADP
bptjm-23	228	7	both	both	CCONJ
bptjm-23	228	8	the	the	DET
bptjm-23	228	9	disease	disease	NOUN
bptjm-23	228	10	and	and	CCONJ
bptjm-23	228	11	methods	method	NOUN
bptjm-23	228	12	used	use	VERB
bptjm-23	228	13	is	be	AUX
bptjm-23	228	14	necessary	necessary	ADJ
bptjm-23	228	15	to	to	PART
bptjm-23	228	16	maintain	maintain	VERB
bptjm-23	228	17	good	good	ADJ
bptjm-23	228	18	quality	quality	NOUN
bptjm-23	228	19	of	of	ADP
bptjm-23	228	20	care	care	NOUN
bptjm-23	228	21	and	and	CCONJ
bptjm-23	228	22	building	build	VERB
bptjm-23	228	23	upon	upon	SCONJ
bptjm-23	228	24	these	these	PRON
bptjm-23	228	25	to	to	PART
bptjm-23	228	26	improve	improve	VERB
bptjm-23	228	27	treatment	treatment	NOUN
bptjm-23	228	28	of	of	ADP
bptjm-23	228	29	copd	copd	NOUN
bptjm-23	228	30	.	.	PUNCT
bptjm-23	229	1	berkeley	berkeley	PROPN
bptjm-23	229	2	pharma	pharma	PROPN
bptjm-23	229	3	tech	tech	PROPN
bptjm-23	229	4	journal	journal	NOUN
bptjm-23	229	5	of	of	ADP
bptjm-23	229	6	medicine	medicine	NOUN
bptjm-23	229	7	|	|	ADV
bptjm-23	229	8	76	76	NUM
bptjm-23	229	9	references	reference	NOUN
bptjm-23	229	10	1	1	NUM
bptjm-23	229	11	.	.	PUNCT
bptjm-23	230	1	baliga	baliga	ADJ
bptjm-23	230	2	uk	uk	PROPN
bptjm-23	230	3	,	,	PUNCT
bptjm-23	230	4	dean	dean	PROPN
bptjm-23	230	5	da	da	PROPN
bptjm-23	230	6	.	.	PUNCT
bptjm-23	231	1	pulmonary	pulmonary	ADJ
bptjm-23	231	2	gene	gene	NOUN
bptjm-23	231	3	delivery	delivery	NOUN
bptjm-23	231	4	-	-	PUNCT
bptjm-23	231	5	realities	reality	NOUN
bptjm-23	231	6	and	and	CCONJ
bptjm-23	231	7	possibilities	possibility	NOUN
bptjm-23	231	8	.	.	PUNCT
bptjm-23	232	1	exp	exp	NOUN
bptjm-23	232	2	biol	biol	PROPN
bptjm-23	232	3	med	med	PROPN
bptjm-23	232	4	(	(	PUNCT
bptjm-23	232	5	maywood	maywood	PROPN
bptjm-23	232	6	)	)	PUNCT
bptjm-23	232	7	.	.	PUNCT
bptjm-23	233	1	2021;246(3):260	2021;246(3):260	NUM
bptjm-23	233	2	-	-	SYM
bptjm-23	233	3	274	274	NUM
bptjm-23	233	4	.	.	PUNCT
bptjm-23	233	5	doi:10.1177/1535370220965985	doi:10.1177/1535370220965985	NOUN
bptjm-23	233	6	2	2	NUM
bptjm-23	233	7	.	.	X
bptjm-23	233	8	kim	kim	PROPN
bptjm-23	233	9	n	n	CCONJ
bptjm-23	233	10	,	,	PUNCT
bptjm-23	233	11	duncan	duncan	PROPN
bptjm-23	233	12	ga	ga	PROPN
bptjm-23	233	13	,	,	PUNCT
bptjm-23	233	14	hanes	hanes	PROPN
bptjm-23	233	15	j	j	PROPN
bptjm-23	233	16	,	,	PUNCT
bptjm-23	233	17	suk	suk	PROPN
bptjm-23	233	18	js	js	PROPN
bptjm-23	233	19	.	.	PUNCT
bptjm-23	234	1	barriers	barrier	NOUN
bptjm-23	234	2	to	to	ADP
bptjm-23	234	3	inhaled	inhaled	ADJ
bptjm-23	234	4	gene	gene	NOUN
bptjm-23	234	5	therapy	therapy	NOUN
bptjm-23	234	6	of	of	ADP
bptjm-23	234	7	obstructive	obstructive	ADJ
bptjm-23	234	8	lung	lung	NOUN
bptjm-23	234	9	diseases	disease	NOUN
bptjm-23	234	10	:	:	PUNCT
bptjm-23	234	11	a	a	DET
bptjm-23	234	12	review	review	NOUN
bptjm-23	234	13	.	.	PUNCT
bptjm-23	235	1	j	j	PROPN
bptjm-23	235	2	control	control	PROPN
bptjm-23	235	3	release	release	PROPN
bptjm-23	235	4	.	.	PUNCT
bptjm-23	236	1	2016;240:465	2016;240:465	NUM
bptjm-23	236	2	-	-	SYM
bptjm-23	236	3	488	488	NUM
bptjm-23	236	4	.	.	PUNCT
bptjm-23	237	1	3	3	X
bptjm-23	237	2	.	.	X
bptjm-23	237	3	passi	passi	PROPN
bptjm-23	237	4	m	m	PROPN
bptjm-23	237	5	,	,	PUNCT
bptjm-23	237	6	shahid	shahid	PROPN
bptjm-23	237	7	s	s	PART
bptjm-23	237	8	,	,	PUNCT
bptjm-23	237	9	chockalingam	chockalingam	PROPN
bptjm-23	237	10	s	s	PROPN
bptjm-23	237	11	,	,	PUNCT
bptjm-23	237	12	sundar	sundar	NOUN
bptjm-23	237	13	ik	ik	PROPN
bptjm-23	237	14	,	,	PUNCT
bptjm-23	237	15	packirisamy	packirisamy	NOUN
bptjm-23	237	16	g.	g.	PROPN
bptjm-23	237	17	conventional	conventional	PROPN
bptjm-23	237	18	and	and	CCONJ
bptjm-23	237	19	nanotechnology	nanotechnology	NOUN
bptjm-23	237	20	based	base	VERB
bptjm-23	237	21	approaches	approach	NOUN
bptjm-23	237	22	to	to	ADP
bptjm-23	237	23	combat	combat	NOUN
bptjm-23	237	24	chronic	chronic	ADJ
bptjm-23	237	25	obstructive	obstructive	ADJ
bptjm-23	237	26	pulmonary	pulmonary	ADJ
bptjm-23	237	27	disease	disease	NOUN
bptjm-23	237	28	:	:	PUNCT
bptjm-23	237	29	implications	implication	NOUN
bptjm-23	237	30	for	for	ADP
bptjm-23	237	31	chronic	chronic	ADJ
bptjm-23	237	32	airway	airway	NOUN
bptjm-23	237	33	diseases	disease	NOUN
bptjm-23	237	34	.	.	PUNCT
bptjm-23	238	1	int	int	NOUN
bptjm-23	238	2	j	j	PROPN
bptjm-23	238	3	nanomedicine	nanomedicine	PROPN
bptjm-23	238	4	.	.	PUNCT
bptjm-23	239	1	2020;15:3803	2020;15:3803	NUM
bptjm-23	239	2	-	-	SYM
bptjm-23	239	3	3826	3826	NUM
bptjm-23	239	4	.	.	PUNCT
bptjm-23	240	1	published	publish	VERB
bptjm-23	240	2	2020	2020	NUM
bptjm-23	240	3	may	may	AUX
bptjm-23	240	4	28	28	NUM
bptjm-23	240	5	.	.	PUNCT
bptjm-23	241	1	doi:10.2147	doi:10.2147	NOUN
bptjm-23	241	2	/	/	SYM
bptjm-23	241	3	ijn.s242516	ijn.s242516	ADJ
bptjm-23	241	4	4	4	NUM
bptjm-23	241	5	.	.	PUNCT
bptjm-23	241	6	voelker	voelker	PROPN
bptjm-23	241	7	r.	r.	PROPN
bptjm-23	241	8	cell	cell	PROPN
bptjm-23	241	9	-	-	PUNCT
bptjm-23	241	10	based	base	VERB
bptjm-23	241	11	gene	gene	NOUN
bptjm-23	241	12	therapy	therapy	NOUN
bptjm-23	241	13	is	be	AUX
bptjm-23	241	14	a	a	DET
bptjm-23	241	15	new	new	ADJ
bptjm-23	241	16	option	option	NOUN
bptjm-23	241	17	for	for	ADP
bptjm-23	241	18	multiple	multiple	ADJ
bptjm-23	241	19	myeloma	myeloma	NOUN
bptjm-23	241	20	.	.	PUNCT
bptjm-23	242	1	jama	jama	PROPN
bptjm-23	242	2	.	.	PUNCT
bptjm-23	243	1	2021;325(17):1713	2021;325(17):1713	X
bptjm-23	243	2	.	.	PUNCT
bptjm-23	244	1	doi:10.1001	doi:10.1001	PROPN
bptjm-23	244	2	/	/	SYM
bptjm-23	245	1	jama.2021.6401	jama.2021.6401	PROPN
bptjm-23	245	2	5	5	NUM
bptjm-23	245	3	.	.	PUNCT
bptjm-23	245	4	narfström	narfström	NOUN
bptjm-23	245	5	,	,	PUNCT
bptjm-23	245	6	k.	k.	PROPN
bptjm-23	245	7	,	,	PUNCT
bptjm-23	245	8	vaegan	vaegan	PROPN
bptjm-23	245	9	,	,	PUNCT
bptjm-23	245	10	katz	katz	PROPN
bptjm-23	245	11	,	,	PUNCT
bptjm-23	245	12	m.	m.	NOUN
bptjm-23	245	13	et	et	PROPN
bptjm-23	245	14	al	al	PROPN
bptjm-23	245	15	.	.	PROPN
bptjm-23	245	16	assessment	assessment	NOUN
bptjm-23	245	17	of	of	ADP
bptjm-23	245	18	structure	structure	NOUN
bptjm-23	245	19	and	and	CCONJ
bptjm-23	245	20	function	function	NOUN
bptjm-23	245	21	over	over	ADP
bptjm-23	245	22	a	a	DET
bptjm-23	245	23	3	3	NUM
bptjm-23	245	24	-	-	PUNCT
bptjm-23	245	25	year	year	NOUN
bptjm-23	245	26	period	period	NOUN
bptjm-23	245	27	after	after	ADP
bptjm-23	245	28	gene	gene	NOUN
bptjm-23	245	29	transfer	transfer	NOUN
bptjm-23	245	30	in	in	ADP
bptjm-23	245	31	rpe65−/−	rpe65−/−	ADJ
bptjm-23	245	32	dogs	dog	NOUN
bptjm-23	245	33	.	.	PUNCT
bptjm-23	246	1	doc	doc	PROPN
bptjm-23	246	2	ophthalmol	ophthalmol	PROPN
bptjm-23	246	3	111	111	NUM
bptjm-23	246	4	,	,	PUNCT
bptjm-23	246	5	39–48	39–48	NUM
bptjm-23	246	6	(	(	PUNCT
bptjm-23	246	7	2005	2005	NUM
bptjm-23	246	8	)	)	PUNCT
bptjm-23	246	9	.	.	PUNCT
bptjm-23	247	1	https://doi.org/10.1007/s10633-005-3159-0	https://doi.org/10.1007/s10633-005-3159-0	NUM
bptjm-23	247	2	6	6	NUM
bptjm-23	247	3	.	.	PUNCT
bptjm-23	248	1	flotte	flotte	PROPN
bptjm-23	248	2	,	,	PUNCT
bptjm-23	248	3	t.	t.	PROPN
bptjm-23	248	4	,	,	PUNCT
bptjm-23	248	5	laube	laube	PROPN
bptjm-23	248	6	,	,	PUNCT
bptjm-23	248	7	b.	b.	PROPN
bptjm-23	248	8	gene	gene	NOUN
bptjm-23	248	9	therapy	therapy	NOUN
bptjm-23	248	10	in	in	ADP
bptjm-23	248	11	cystic	cystic	ADJ
bptjm-23	248	12	fibrosis	fibrosis	NOUN
bptjm-23	248	13	.	.	PUNCT
bptjm-23	249	1	chest	chest	NOUN
bptjm-23	249	2	.	.	PUNCT
bptjm-23	250	1	2001;3;124s-131s	2001;3;124s-131s	NOUN
bptjm-23	250	2	.	.	PUNCT
bptjm-23	251	1	https://doi.org/10.1378/chest.120.3_suppl.124s	https://doi.org/10.1378/chest.120.3_suppl.124s	PROPN
bptjm-23	251	2	7	7	NUM
bptjm-23	251	3	.	.	PUNCT
bptjm-23	251	4	saiman	saiman	PROPN
bptjm-23	251	5	l	l	PROPN
bptjm-23	251	6	,	,	PUNCT
bptjm-23	251	7	cacalano	cacalano	PROPN
bptjm-23	251	8	g	g	PROPN
bptjm-23	251	9	,	,	PUNCT
bptjm-23	251	10	prince	prince	PROPN
bptjm-23	251	11	a.	a.	PROPN
bptjm-23	251	12	pseudomonas	pseudomonas	PROPN
bptjm-23	251	13	cepacia	cepacia	NOUN
bptjm-23	251	14	adherence	adherence	NOUN
bptjm-23	251	15	to	to	ADP
bptjm-23	251	16	respiratory	respiratory	ADJ
bptjm-23	251	17	epithelial	epithelial	ADJ
bptjm-23	251	18	cells	cell	NOUN
bptjm-23	251	19	is	be	AUX
bptjm-23	251	20	enhanced	enhance	VERB
bptjm-23	251	21	by	by	ADP
bptjm-23	251	22	pseudomonas	pseudomona	NOUN
bptjm-23	251	23	aeruginosa	aeruginosa	NOUN
bptjm-23	251	24	.	.	PUNCT
bptjm-23	252	1	infect	infect	VERB
bptjm-23	252	2	immun	immun	PROPN
bptjm-23	252	3	.	.	PUNCT
bptjm-23	253	1	1990;58(8):2578	1990;58(8):2578	NUM
bptjm-23	253	2	-	-	SYM
bptjm-23	253	3	2584	2584	NUM
bptjm-23	253	4	.	.	PUNCT
bptjm-23	254	1	doi:10.1128	doi:10.1128	NOUN
bptjm-23	254	2	/	/	SYM
bptjm-23	254	3	iai.58.8.2578	iai.58.8.2578	PROPN
bptjm-23	254	4	-	-	PUNCT
bptjm-23	254	5	2584.1990	2584.1990	NUM
bptjm-23	254	6	8	8	NUM
bptjm-23	254	7	.	.	PUNCT
bptjm-23	255	1	kim	kim	PROPN
bptjm-23	255	2	wj	wj	PROPN
bptjm-23	255	3	,	,	PUNCT
bptjm-23	255	4	lee	lee	PROPN
bptjm-23	255	5	sd	sd	PROPN
bptjm-23	255	6	.	.	PUNCT
bptjm-23	256	1	candidate	candidate	NOUN
bptjm-23	256	2	genes	gene	NOUN
bptjm-23	256	3	for	for	ADP
bptjm-23	256	4	copd	copd	NOUN
bptjm-23	256	5	:	:	PUNCT
bptjm-23	256	6	current	current	ADJ
bptjm-23	256	7	evidence	evidence	NOUN
bptjm-23	256	8	and	and	CCONJ
bptjm-23	256	9	research	research	NOUN
bptjm-23	256	10	.	.	PUNCT
bptjm-23	257	1	int	int	PROPN
bptjm-23	258	1	j	j	PROPN
bptjm-23	258	2	chron	chron	NOUN
bptjm-23	258	3	obstruct	obstruct	VERB
bptjm-23	258	4	pulmon	pulmon	PROPN
bptjm-23	258	5	dis	dis	PROPN
bptjm-23	258	6	.	.	PUNCT
bptjm-23	259	1	2015;10:2249	2015;10:2249	NUM
bptjm-23	259	2	-	-	SYM
bptjm-23	259	3	2255	2255	NUM
bptjm-23	259	4	.	.	PUNCT
bptjm-23	260	1	published	publish	VERB
bptjm-23	260	2	2015	2015	NUM
bptjm-23	260	3	oct	oct	NOUN
bptjm-23	260	4	19	19	NUM
bptjm-23	260	5	.	.	PUNCT
bptjm-23	260	6	doi:10.2147	doi:10.2147	NOUN
bptjm-23	260	7	/	/	SYM
bptjm-23	260	8	copd.s80227	copd.s80227	PROPN
bptjm-23	260	9	9	9	NUM
bptjm-23	260	10	.	.	X
bptjm-23	260	11	afzal	afzal	PROPN
bptjm-23	260	12	s	s	PROPN
bptjm-23	260	13	,	,	PUNCT
bptjm-23	260	14	ramzan	ramzan	PROPN
bptjm-23	260	15	k	k	PROPN
bptjm-23	260	16	,	,	PUNCT
bptjm-23	260	17	waqar	waqar	PROPN
bptjm-23	260	18	ab	ab	PROPN
bptjm-23	260	19	(	(	PUNCT
bptjm-23	260	20	2020	2020	NUM
bptjm-23	260	21	)	)	PUNCT
bptjm-23	260	22	.	.	PUNCT
bptjm-23	261	1	alternative	alternative	ADJ
bptjm-23	261	2	approaches	approach	NOUN
bptjm-23	261	3	for	for	ADP
bptjm-23	261	4	the	the	DET
bptjm-23	261	5	treatment	treatment	NOUN
bptjm-23	261	6	of	of	ADP
bptjm-23	261	7	asthma	asthma	NOUN
bptjm-23	261	8	and	and	CCONJ
bptjm-23	261	9	copd	copd	PROPN
bptjm-23	261	10	:	:	PUNCT
bptjm-23	261	11	focus	focus	VERB
bptjm-23	261	12	on	on	ADP
bptjm-23	261	13	cell	cell	NOUN
bptjm-23	261	14	-	-	PUNCT
bptjm-23	261	15	based	base	VERB
bptjm-23	261	16	therapies	therapy	NOUN
bptjm-23	261	17	,	,	PUNCT
bptjm-23	261	18	epigenetics	epigenetic	NOUN
bptjm-23	261	19	,	,	PUNCT
bptjm-23	261	20	and	and	CCONJ
bptjm-23	261	21	gene	gene	NOUN
bptjm-23	261	22	silencing	silence	VERB
bptjm-23	261	23	approaches	approach	NOUN
bptjm-23	261	24	.	.	PUNCT
bptjm-23	262	1	adv	adv	PROPN
bptjm-23	262	2	.	.	PUNCT
bptjm-23	262	3	life	life	PROPN
bptjm-23	262	4	sci	sci	PROPN
bptjm-23	262	5	.	.	PUNCT
bptjm-23	263	1	7(3	7(3	NUM
bptjm-23	263	2	):	):	PUNCT
bptjm-23	263	3	181	181	NUM
bptjm-23	263	4	-	-	SYM
bptjm-23	263	5	189	189	NUM
bptjm-23	263	6	.	.	PUNCT
bptjm-23	264	1	10	10	NUM
bptjm-23	264	2	.	.	PUNCT
bptjm-23	265	1	liu	liu	PROPN
bptjm-23	265	2	et	et	PROPN
bptjm-23	265	3	al	al	PROPN
bptjm-23	265	4	.	.	PROPN
bptjm-23	265	5	,	,	PUNCT
bptjm-23	265	6	cationic	cationic	ADJ
bptjm-23	265	7	liposome	liposome	NOUN
bptjm-23	265	8	-	-	PUNCT
bptjm-23	265	9	mediated	mediate	VERB
bptjm-23	265	10	intravenous	intravenous	ADJ
bptjm-23	265	11	gene	gene	NOUN
bptjm-23	265	12	delivery	delivery	NOUN
bptjm-23	265	13	.	.	PUNCT
bptjm-23	266	1	j.	j.	PROPN
bptjm-23	266	2	biol	biol	PROPN
bptjm-23	266	3	.	.	PUNCT
bptjm-23	267	1	chem	chem	PROPN
bptjm-23	267	2	.	.	PUNCT
bptjm-23	268	1	,	,	PUNCT
bptjm-23	268	2	270	270	NUM
bptjm-23	268	3	(	(	PUNCT
bptjm-23	268	4	1995	1995	NUM
bptjm-23	268	5	)	)	PUNCT
bptjm-23	268	6	,	,	PUNCT
bptjm-23	268	7	pp	pp	ADP
bptjm-23	268	8	.	.	PUNCT
bptjm-23	269	1	24864	24864	NUM
bptjm-23	269	2	-	-	SYM
bptjm-23	269	3	24870	24870	NUM
bptjm-23	269	4	11	11	NUM
bptjm-23	269	5	.	.	PUNCT
bptjm-23	270	1	balazs	balazs	PROPN
bptjm-23	270	2	da	da	PROPN
bptjm-23	270	3	,	,	PUNCT
bptjm-23	270	4	godbey	godbey	PROPN
bptjm-23	270	5	w.	w.	PROPN
bptjm-23	270	6	liposomes	liposome	NOUN
bptjm-23	270	7	for	for	ADP
bptjm-23	270	8	use	use	NOUN
bptjm-23	270	9	in	in	ADP
bptjm-23	270	10	gene	gene	NOUN
bptjm-23	270	11	delivery	delivery	NOUN
bptjm-23	270	12	.	.	PUNCT
bptjm-23	271	1	j	j	PROPN
bptjm-23	271	2	drug	drug	NOUN
bptjm-23	271	3	deliv	deliv	NOUN
bptjm-23	271	4	.	.	PUNCT
bptjm-23	272	1	2011;2011:326497	2011;2011:326497	NUM
bptjm-23	272	2	.	.	PUNCT
bptjm-23	273	1	doi:10.1155/2011/326497	doi:10.1155/2011/326497	NUM
bptjm-23	273	2	12	12	NUM
bptjm-23	273	3	.	.	PUNCT
bptjm-23	274	1	cardarelli	cardarelli	PROPN
bptjm-23	275	1	f	f	PROPN
bptjm-23	275	2	,	,	PUNCT
bptjm-23	275	3	digiacomo	digiacomo	PROPN
bptjm-23	275	4	l	l	NOUN
bptjm-23	275	5	,	,	PUNCT
bptjm-23	275	6	marchini	marchini	PROPN
bptjm-23	275	7	c	c	NOUN
bptjm-23	275	8	,	,	PUNCT
bptjm-23	275	9	et	et	PROPN
bptjm-23	275	10	al	al	PROPN
bptjm-23	275	11	.	.	PUNCT
bptjm-23	276	1	the	the	DET
bptjm-23	276	2	intracellular	intracellular	ADJ
bptjm-23	276	3	tra	tra	ADJ
bptjm-23	276	4	�	�	ADJ
bptjm-23	276	5	cking	cking	ADJ
bptjm-23	276	6	mechanism	mechanism	NOUN
bptjm-23	276	7	of	of	ADP
bptjm-23	276	8	lipofectamine	lipofectamine	NOUN
bptjm-23	276	9	-	-	PUNCT
bptjm-23	276	10	based	base	VERB
bptjm-23	276	11	transfection	transfection	NOUN
bptjm-23	276	12	reagents	reagent	NOUN
bptjm-23	276	13	and	and	CCONJ
bptjm-23	276	14	its	its	PRON
bptjm-23	276	15	implication	implication	NOUN
bptjm-23	276	16	for	for	ADP
bptjm-23	276	17	gene	gene	NOUN
bptjm-23	276	18	delivery	delivery	NOUN
bptjm-23	276	19	.	.	PUNCT
bptjm-23	277	1	sci	sci	PROPN
bptjm-23	277	2	rep	rep	PROPN
bptjm-23	277	3	.	.	PROPN
bptjm-23	277	4	2016;6:25879	2016;6:25879	PROPN
bptjm-23	277	5	.	.	PUNCT
bptjm-23	278	1	published	publish	VERB
bptjm-23	278	2	2016	2016	NUM
bptjm-23	278	3	may	may	AUX
bptjm-23	278	4	11	11	NUM
bptjm-23	278	5	.	.	PUNCT
bptjm-23	279	1	doi:10.1038	doi:10.1038	NOUN
bptjm-23	279	2	/	/	SYM
bptjm-23	279	3	srep25879	srep25879	PROPN
bptjm-23	279	4	13	13	NUM
bptjm-23	279	5	.	.	PUNCT
bptjm-23	280	1	yang	yang	PROPN
bptjm-23	280	2	j	j	PROPN
bptjm-23	280	3	,	,	PUNCT
bptjm-23	280	4	bahreman	bahreman	PROPN
bptjm-23	280	5	a	a	PROPN
bptjm-23	280	6	,	,	PUNCT
bptjm-23	280	7	daudey	daudey	ADJ
bptjm-23	280	8	g	g	NOUN
bptjm-23	280	9	,	,	PUNCT
bptjm-23	280	10	bussmann	bussmann	PROPN
bptjm-23	280	11	j	j	PROPN
bptjm-23	280	12	,	,	PUNCT
bptjm-23	280	13	olsthoorn	olsthoorn	PROPN
bptjm-23	280	14	rc	rc	PROPN
bptjm-23	280	15	,	,	PUNCT
bptjm-23	280	16	kros	kros	PROPN
bptjm-23	280	17	a.	a.	PROPN
bptjm-23	280	18	drug	drug	PROPN
bptjm-23	280	19	delivery	delivery	NOUN
bptjm-23	280	20	via	via	ADP
bptjm-23	280	21	cell	cell	NOUN
bptjm-23	280	22	membrane	membrane	NOUN
bptjm-23	280	23	fusion	fusion	NOUN
bptjm-23	280	24	using	use	VERB
bptjm-23	280	25	lipopeptide	lipopeptide	PROPN
bptjm-23	280	26	modi	modi	PROPN
bptjm-23	280	27	�	�	PROPN
bptjm-23	280	28	ed	ed	PROPN
bptjm-23	280	29	liposomes	liposome	NOUN
bptjm-23	280	30	.	.	PUNCT
bptjm-23	281	1	acs	acs	PROPN
bptjm-23	281	2	cent	cent	PROPN
bptjm-23	281	3	sci	sci	PROPN
bptjm-23	281	4	.	.	PROPN
bptjm-23	281	5	2016;2(9):621	2016;2(9):621	NUM
bptjm-23	281	6	-	-	SYM
bptjm-23	281	7	630	630	NUM
bptjm-23	281	8	.	.	PUNCT
bptjm-23	282	1	doi:10.1021	doi:10.1021	ADJ
bptjm-23	282	2	/	/	SYM
bptjm-23	282	3	acscentsci.6b00172	acscentsci.6b00172	PROPN
bptjm-23	282	4	14	14	NUM
bptjm-23	282	5	.	.	PUNCT
bptjm-23	283	1	hao	hao	PROPN
bptjm-23	283	2	l	l	PROPN
bptjm-23	283	3	,	,	PUNCT
bptjm-23	283	4	wu	wu	PROPN
bptjm-23	283	5	y	y	PROPN
bptjm-23	283	6	,	,	PUNCT
bptjm-23	283	7	zhang	zhang	PROPN
bptjm-23	283	8	y	y	PROPN
bptjm-23	283	9	,	,	PUNCT
bptjm-23	283	10	et	et	PROPN
bptjm-23	283	11	al	al	PROPN
bptjm-23	283	12	.	.	PROPN
bptjm-23	284	1	combinational	combinational	PROPN
bptjm-23	284	2	prr	prr	PROPN
bptjm-23	284	3	agonists	agonist	NOUN
bptjm-23	284	4	in	in	ADP
bptjm-23	284	5	liposomal	liposomal	ADJ
bptjm-23	284	6	adjuvant	adjuvant	NOUN
bptjm-23	284	7	enhances	enhance	VERB
bptjm-23	284	8	immunogenicity	immunogenicity	NOUN
bptjm-23	284	9	and	and	CCONJ
bptjm-23	284	10	protective	protective	ADJ
bptjm-23	284	11	e	e	NOUN
bptjm-23	284	12	�	�	NOUN
bptjm-23	284	13	cacy	cacy	NOUN
bptjm-23	284	14	in	in	ADP
bptjm-23	284	15	a	a	DET
bptjm-23	284	16	tuberculosis	tuberculosis	NOUN
bptjm-23	284	17	subunit	subunit	NOUN
bptjm-23	284	18	vaccine	vaccine	NOUN
bptjm-23	284	19	.	.	PUNCT
bptjm-23	285	1	frontiers	frontier	NOUN
bptjm-23	285	2	in	in	ADP
bptjm-23	285	3	immunology	immunology	NOUN
bptjm-23	285	4	.	.	PUNCT
bptjm-23	286	1	2020;11	2020;11	NUM
bptjm-23	286	2	.	.	PUNCT
bptjm-23	287	1	https://www.frontiersin.org/article/10.3389/�m	https://www.frontiersin.org/article/10.3389/�m	VERB
bptjm-23	287	2	mu.2020.575504	mu.2020.575504	PROPN
bptjm-23	287	3	berkeley	berkeley	PROPN
bptjm-23	287	4	pharma	pharma	PROPN
bptjm-23	287	5	tech	tech	NOUN
bptjm-23	287	6	journal	journal	NOUN
bptjm-23	287	7	of	of	ADP
bptjm-23	287	8	medicine	medicine	NOUN
bptjm-23	287	9	|	|	ADV
bptjm-23	287	10	77	77	NUM
bptjm-23	287	11	15	15	NUM
bptjm-23	287	12	.	.	PUNCT
bptjm-23	288	1	griesenbach	griesenbach	PROPN
bptjm-23	288	2	u	u	NOUN
bptjm-23	288	3	,	,	PUNCT
bptjm-23	288	4	pytel	pytel	PROPN
bptjm-23	288	5	km	km	PROPN
bptjm-23	288	6	,	,	PUNCT
bptjm-23	288	7	alton	alton	PROPN
bptjm-23	288	8	ew	ew	PROPN
bptjm-23	288	9	.	.	PROPN
bptjm-23	288	10	cystic	cystic	ADJ
bptjm-23	288	11	fibrosis	fibrosis	NOUN
bptjm-23	288	12	gene	gene	NOUN
bptjm-23	288	13	therapy	therapy	NOUN
bptjm-23	288	14	in	in	ADP
bptjm-23	288	15	the	the	DET
bptjm-23	288	16	uk	uk	PROPN
bptjm-23	288	17	and	and	CCONJ
bptjm-23	288	18	elsewhere	elsewhere	ADV
bptjm-23	288	19	.	.	PUNCT
bptjm-23	289	1	hum	hum	PROPN
bptjm-23	289	2	gene	gene	PROPN
bptjm-23	289	3	ther	ther	ADV
bptjm-23	289	4	.	.	PUNCT
bptjm-23	290	1	2015;26(5):266	2015;26(5):266	NOUN
bptjm-23	290	2	-	-	PUNCT
bptjm-23	290	3	275	275	NUM
bptjm-23	290	4	.	.	PUNCT
bptjm-23	290	5	doi:10.1089	doi:10.1089	NOUN
bptjm-23	290	6	/	/	SYM
bptjm-23	290	7	hum.2015.027	hum.2015.027	PROPN
bptjm-23	290	8	16	16	NUM
bptjm-23	290	9	.	.	PUNCT
bptjm-23	291	1	ernst	ernst	PROPN
bptjm-23	291	2	,	,	PUNCT
bptjm-23	291	3	n.	n.	NOUN
bptjm-23	291	4	,	,	PUNCT
bptjm-23	291	5	ulrichskötter	ulrichskötter	NOUN
bptjm-23	291	6	,	,	PUNCT
bptjm-23	291	7	s.	s.	PROPN
bptjm-23	291	8	,	,	PUNCT
bptjm-23	291	9	schmalix	schmalix	ADJ
bptjm-23	291	10	,	,	PUNCT
bptjm-23	291	11	w.a	w.a	PROPN
bptjm-23	291	12	.	.	PROPN
bptjm-23	291	13	,	,	PUNCT
bptjm-23	291	14	rädler	rädler	NOUN
bptjm-23	291	15	,	,	PUNCT
bptjm-23	291	16	j.	j.	PROPN
bptjm-23	291	17	,	,	PUNCT
bptjm-23	291	18	galneder	galneder	PROPN
bptjm-23	291	19	,	,	PUNCT
bptjm-23	291	20	r.	r.	PROPN
bptjm-23	291	21	,	,	PUNCT
bptjm-23	291	22	mayer	mayer	PROPN
bptjm-23	291	23	,	,	PUNCT
bptjm-23	291	24	e.	e.	PROPN
bptjm-23	291	25	,	,	PUNCT
bptjm-23	291	26	gersting	gersting	NOUN
bptjm-23	291	27	,	,	PUNCT
bptjm-23	291	28	s.	s.	PROPN
bptjm-23	291	29	,	,	PUNCT
bptjm-23	291	30	plank	plank	PROPN
bptjm-23	291	31	,	,	PUNCT
bptjm-23	291	32	c.	c.	PROPN
bptjm-23	291	33	,	,	PUNCT
bptjm-23	291	34	reinhardt	reinhardt	PROPN
bptjm-23	291	35	,	,	PUNCT
bptjm-23	291	36	d.	d.	PROPN
bptjm-23	291	37	and	and	CCONJ
bptjm-23	291	38	rosenecker	rosenecker	VERB
bptjm-23	291	39	,	,	PUNCT
bptjm-23	291	40	j.	j.	PROPN
bptjm-23	291	41	(	(	PUNCT
bptjm-23	291	42	1999	1999	NUM
bptjm-23	291	43	)	)	PUNCT
bptjm-23	291	44	,	,	PUNCT
bptjm-23	291	45	interaction	interaction	NOUN
bptjm-23	291	46	of	of	ADP
bptjm-23	291	47	liposomal	liposomal	ADJ
bptjm-23	291	48	and	and	CCONJ
bptjm-23	291	49	polycationic	polycationic	ADJ
bptjm-23	291	50	transfection	transfection	NOUN
bptjm-23	291	51	complexes	complexe	VERB
bptjm-23	291	52	with	with	ADP
bptjm-23	291	53	pulmonary	pulmonary	ADJ
bptjm-23	291	54	surfactant	surfactant	NOUN
bptjm-23	291	55	.	.	PUNCT
bptjm-23	292	1	j.	j.	PROPN
bptjm-23	292	2	gene	gene	PROPN
bptjm-23	292	3	med	me	VERB
bptjm-23	292	4	.	.	PUNCT
bptjm-23	292	5	,	,	PUNCT
bptjm-23	292	6	1	1	NUM
bptjm-23	292	7	:	:	PUNCT
bptjm-23	292	8	331	331	NUM
bptjm-23	292	9	-	-	SYM
bptjm-23	292	10	340	340	NUM
bptjm-23	292	11	.	.	PUNCT
bptjm-23	293	1	https://doi.org/10.1002/(sici)1521-2254(19	https://doi.org/10.1002/(sici)1521-2254(19	PROPN
bptjm-23	293	2	9909/10)1:5<331::aid	9909/10)1:5<331::aid	NUM
bptjm-23	293	3	-	-	PUNCT
bptjm-23	293	4	jgm60>3.0.co;2	jgm60>3.0.co;2	NOUN
bptjm-23	293	5	-	-	PUNCT
bptjm-23	293	6	8	8	NUM
bptjm-23	293	7	17	17	NUM
bptjm-23	293	8	.	.	PUNCT
bptjm-23	294	1	chen	chen	PROPN
bptjm-23	294	2	d	d	PROPN
bptjm-23	294	3	,	,	PUNCT
bptjm-23	294	4	liu	liu	PROPN
bptjm-23	294	5	j	j	PROPN
bptjm-23	294	6	,	,	PUNCT
bptjm-23	294	7	wu	wu	PROPN
bptjm-23	294	8	j	j	PROPN
bptjm-23	294	9	,	,	PUNCT
bptjm-23	294	10	suk	suk	PROPN
bptjm-23	294	11	js	js	PROPN
bptjm-23	294	12	.	.	PUNCT
bptjm-23	295	1	enhancing	enhance	VERB
bptjm-23	295	2	nanoparticle	nanoparticle	NOUN
bptjm-23	295	3	penetration	penetration	NOUN
bptjm-23	295	4	through	through	ADP
bptjm-23	295	5	airway	airway	NOUN
bptjm-23	295	6	mucus	mucus	NOUN
bptjm-23	295	7	to	to	PART
bptjm-23	295	8	improve	improve	VERB
bptjm-23	295	9	drug	drug	NOUN
bptjm-23	295	10	delivery	delivery	NOUN
bptjm-23	295	11	e	e	PROPN
bptjm-23	295	12	�	�	NOUN
bptjm-23	295	13	cacy	cacy	NOUN
bptjm-23	295	14	in	in	ADP
bptjm-23	295	15	the	the	DET
bptjm-23	295	16	lung	lung	NOUN
bptjm-23	295	17	.	.	PUNCT
bptjm-23	296	1	expert	expert	NOUN
bptjm-23	296	2	opin	opin	NOUN
bptjm-23	296	3	drug	drug	NOUN
bptjm-23	296	4	deliv	deliv	NOUN
bptjm-23	296	5	.	.	PUNCT
bptjm-23	297	1	2021;18(5):595	2021;18(5):595	NOUN
bptjm-23	297	2	-	-	PUNCT
bptjm-23	297	3	606	606	NUM
bptjm-23	297	4	.	.	PUNCT
bptjm-23	298	1	doi:10.1080/17425247.2021.1854222	doi:10.1080/17425247.2021.1854222	NOUN
bptjm-23	298	2	18	18	NUM
bptjm-23	298	3	.	.	PUNCT
bptjm-23	299	1	cone	cone	PROPN
bptjm-23	299	2	ra	ra	PROPN
bptjm-23	299	3	.	.	PUNCT
bptjm-23	299	4	barrier	barrier	NOUN
bptjm-23	299	5	properties	property	NOUN
bptjm-23	299	6	of	of	ADP
bptjm-23	299	7	mucus	mucus	NOUN
bptjm-23	299	8	.	.	PUNCT
bptjm-23	300	1	adv	adv	PROPN
bptjm-23	300	2	drug	drug	PROPN
bptjm-23	300	3	deliv	deliv	PROPN
bptjm-23	300	4	rev	rev	VERB
bptjm-23	300	5	.	.	PUNCT
bptjm-23	301	1	2009;61(2):75	2009;61(2):75	NUM
bptjm-23	301	2	-	-	SYM
bptjm-23	301	3	85	85	NUM
bptjm-23	301	4	.	.	PUNCT
bptjm-23	301	5	doi:10.1016	doi:10.1016	PROPN
bptjm-23	301	6	/	/	SYM
bptjm-23	301	7	j.addr.2008.09.008	j.addr.2008.09.008	PROPN
bptjm-23	301	8	19	19	NUM
bptjm-23	301	9	.	.	PUNCT
bptjm-23	302	1	tosi	tosi	PROPN
bptjm-23	302	2	g.	g.	PROPN
bptjm-23	302	3	,	,	PUNCT
bptjm-23	302	4	bortot	bortot	PROPN
bptjm-23	302	5	b.	b.	PROPN
bptjm-23	302	6	,	,	PUNCT
bptjm-23	302	7	ruozi	ruozi	PROPN
bptjm-23	302	8	b.	b.	PROPN
bptjm-23	302	9	,	,	PUNCT
bptjm-23	302	10	dolcetta	dolcetta	PROPN
bptjm-23	302	11	d.	d.	PROPN
bptjm-23	302	12	,	,	PUNCT
bptjm-23	302	13	vandelli	vandelli	PROPN
bptjm-23	302	14	m.a	m.a	PROPN
bptjm-23	302	15	.	.	PROPN
bptjm-23	302	16	,	,	PUNCT
bptjm-23	302	17	forni	forni	PROPN
bptjm-23	302	18	f.	f.	PROPN
bptjm-23	302	19	and	and	CCONJ
bptjm-23	302	20	severini	severini	PROPN
bptjm-23	302	21	g.m	g.m	PROPN
bptjm-23	302	22	.	.	PROPN
bptjm-23	302	23	,	,	PUNCT
bptjm-23	302	24	potential	potential	ADJ
bptjm-23	302	25	use	use	NOUN
bptjm-23	302	26	of	of	ADP
bptjm-23	302	27	polymeric	polymeric	ADJ
bptjm-23	302	28	nanoparticles	nanoparticle	NOUN
bptjm-23	302	29	for	for	ADP
bptjm-23	302	30	drug	drug	NOUN
bptjm-23	302	31	delivery	delivery	NOUN
bptjm-23	302	32	across	across	ADP
bptjm-23	302	33	the	the	DET
bptjm-23	302	34	blood	blood	NOUN
bptjm-23	302	35	-	-	PUNCT
bptjm-23	302	36	brain	brain	NOUN
bptjm-23	302	37	barrier	barrier	NOUN
bptjm-23	302	38	,	,	PUNCT
bptjm-23	302	39	curr	curr	PROPN
bptjm-23	302	40	med	med	PROPN
bptjm-23	302	41	chem	chem	NOUN
bptjm-23	302	42	.	.	PUNCT
bptjm-23	303	1	2013	2013	NUM
bptjm-23	303	2	;	;	PUNCT
bptjm-23	303	3	20(17	20(17	NUM
bptjm-23	303	4	)	)	PUNCT
bptjm-23	303	5	.	.	PUNCT
bptjm-23	304	1	https://dx.doi.org/10.2174/0929867311320170006	https://dx.doi.org/10.2174/0929867311320170006	PROPN
bptjm-23	304	2	20	20	NUM
bptjm-23	305	1	.	.	PUNCT
bptjm-23	305	2	liang	liang	PROPN
bptjm-23	305	3	,	,	PUNCT
bptjm-23	305	4	g.f	g.f	PROPN
bptjm-23	305	5	.	.	PROPN
bptjm-23	305	6	,	,	PUNCT
bptjm-23	305	7	zhu	zhu	PROPN
bptjm-23	305	8	,	,	PUNCT
bptjm-23	305	9	y.l	y.l	PROPN
bptjm-23	305	10	.	.	PROPN
bptjm-23	305	11	,	,	PUNCT
bptjm-23	305	12	sun	sun	PROPN
bptjm-23	305	13	,	,	PUNCT
bptjm-23	305	14	b.	b.	PROPN
bptjm-23	305	15	et	et	PROPN
bptjm-23	305	16	al	al	PROPN
bptjm-23	305	17	.	.	PROPN
bptjm-23	305	18	plga	plga	NOUN
bptjm-23	305	19	-	-	PUNCT
bptjm-23	305	20	based	base	VERB
bptjm-23	305	21	gene	gene	NOUN
bptjm-23	305	22	delivering	deliver	VERB
bptjm-23	305	23	nanoparticle	nanoparticle	NOUN
bptjm-23	305	24	enhance	enhance	VERB
bptjm-23	305	25	suppression	suppression	NOUN
bptjm-23	305	26	e	e	NOUN
bptjm-23	305	27	�	�	NOUN
bptjm-23	305	28	ect	ect	VERB
bptjm-23	305	29	of	of	ADP
bptjm-23	305	30	mirna	mirna	NOUN
bptjm-23	305	31	in	in	ADP
bptjm-23	305	32	hepg2	hepg2	NOUN
bptjm-23	305	33	cells	cell	NOUN
bptjm-23	305	34	.	.	PUNCT
bptjm-23	306	1	nanoscale	nanoscale	NOUN
bptjm-23	306	2	res	re	NOUN
bptjm-23	306	3	lett	lett	PROPN
bptjm-23	306	4	.	.	PROPN
bptjm-23	307	1	6	6	NUM
bptjm-23	307	2	,	,	PUNCT
bptjm-23	307	3	447	447	NUM
bptjm-23	307	4	(	(	PUNCT
bptjm-23	307	5	2011	2011	NUM
bptjm-23	307	6	)	)	PUNCT
bptjm-23	307	7	.	.	PUNCT
bptjm-23	308	1	https://doi.org/10.1186/1556-276x-6-447	https://doi.org/10.1186/1556-276x-6-447	PROPN
bptjm-23	308	2	21	21	NUM
bptjm-23	308	3	.	.	PUNCT
bptjm-23	309	1	bivas	bivas	NOUN
bptjm-23	309	2	-	-	PUNCT
bptjm-23	309	3	benita	benita	PROPN
bptjm-23	309	4	m	m	PROPN
bptjm-23	309	5	,	,	PUNCT
bptjm-23	309	6	romeijn	romeijn	PROPN
bptjm-23	309	7	s	s	PROPN
bptjm-23	309	8	,	,	PUNCT
bptjm-23	309	9	junginger	junginger	PROPN
bptjm-23	309	10	he	he	PRON
bptjm-23	309	11	,	,	PUNCT
bptjm-23	309	12	borchard	borchard	PROPN
bptjm-23	309	13	g.	g.	PROPN
bptjm-23	309	14	plga	plga	PROPN
bptjm-23	309	15	–	–	PUNCT
bptjm-23	309	16	pei	pei	PROPN
bptjm-23	309	17	nanoparticles	nanoparticle	NOUN
bptjm-23	309	18	for	for	ADP
bptjm-23	309	19	gene	gene	NOUN
bptjm-23	309	20	delivery	delivery	NOUN
bptjm-23	309	21	to	to	ADP
bptjm-23	309	22	pulmonary	pulmonary	ADJ
bptjm-23	309	23	epithelium	epithelium	NOUN
bptjm-23	309	24	.	.	PUNCT
bptjm-23	310	1	euro	euro	PROPN
bptjm-23	310	2	j	j	PROPN
bptjm-23	310	3	pharma	pharma	PROPN
bptjm-23	310	4	biopharm	biopharm	NOUN
bptjm-23	310	5	.	.	PUNCT
bptjm-23	311	1	2004;58(1):1	2004;58(1):1	NUM
bptjm-23	311	2	-	-	SYM
bptjm-23	311	3	6	6	NUM
bptjm-23	311	4	.	.	PUNCT
bptjm-23	311	5	doi	doi	NOUN
bptjm-23	311	6	:	:	PUNCT
bptjm-23	311	7	https://doi.org/10.1016	https://doi.org/10.1016	PROPN
bptjm-23	311	8	/	/	SYM
bptjm-23	311	9	j.ejpb.2004.03.008	j.ejpb.2004.03.008	NOUN
bptjm-23	311	10	22	22	NUM
bptjm-23	311	11	.	.	PUNCT
bptjm-23	312	1	baliga	baliga	PROPN
bptjm-23	312	2	uk	uk	PROPN
bptjm-23	312	3	,	,	PUNCT
bptjm-23	312	4	dean	dean	PROPN
bptjm-23	312	5	da	da	PROPN
bptjm-23	312	6	.	.	PUNCT
bptjm-23	313	1	pulmonary	pulmonary	ADJ
bptjm-23	313	2	gene	gene	NOUN
bptjm-23	313	3	delivery	delivery	NOUN
bptjm-23	313	4	-	-	PUNCT
bptjm-23	313	5	realities	reality	NOUN
bptjm-23	313	6	and	and	CCONJ
bptjm-23	313	7	possibilities	possibility	NOUN
bptjm-23	313	8	.	.	PUNCT
bptjm-23	314	1	exp	exp	NOUN
bptjm-23	314	2	biol	biol	PROPN
bptjm-23	314	3	med	med	PROPN
bptjm-23	314	4	(	(	PUNCT
bptjm-23	314	5	maywood	maywood	PROPN
bptjm-23	314	6	)	)	PUNCT
bptjm-23	314	7	.	.	PUNCT
bptjm-23	315	1	2021;246(3):260	2021;246(3):260	NUM
bptjm-23	315	2	-	-	SYM
bptjm-23	315	3	274	274	NUM
bptjm-23	315	4	.	.	PUNCT
bptjm-23	315	5	doi:10.1177/1535370220965985	doi:10.1177/1535370220965985	NOUN
bptjm-23	315	6	23	23	NUM
bptjm-23	315	7	.	.	PUNCT
bptjm-23	316	1	shen	shen	PROPN
bptjm-23	316	2	y	y	PROPN
bptjm-23	316	3	,	,	PUNCT
bptjm-23	316	4	huang	huang	PROPN
bptjm-23	316	5	s	s	PROPN
bptjm-23	316	6	,	,	PUNCT
bptjm-23	316	7	kang	kang	PROPN
bptjm-23	316	8	j	j	PROPN
bptjm-23	316	9	,	,	PUNCT
bptjm-23	316	10	et	et	PROPN
bptjm-23	316	11	al	al	PROPN
bptjm-23	316	12	.	.	PUNCT
bptjm-23	316	13	management	management	PROPN
bptjm-23	316	14	of	of	ADP
bptjm-23	316	15	airway	airway	NOUN
bptjm-23	316	16	mucus	mucus	NOUN
bptjm-23	316	17	hypersecretion	hypersecretion	NOUN
bptjm-23	316	18	in	in	ADP
bptjm-23	316	19	chronic	chronic	ADJ
bptjm-23	316	20	airway	airway	NOUN
bptjm-23	316	21	in	in	ADP
bptjm-23	316	22	�	�	PROPN
bptjm-23	316	23	ammatory	ammatory	NOUN
bptjm-23	316	24	disease	disease	NOUN
bptjm-23	316	25	:	:	PUNCT
bptjm-23	316	26	chinese	chinese	ADJ
bptjm-23	316	27	expert	expert	NOUN
bptjm-23	316	28	consensus	consensus	NOUN
bptjm-23	316	29	(	(	PUNCT
bptjm-23	316	30	english	english	PROPN
bptjm-23	316	31	edition	edition	PROPN
bptjm-23	316	32	)	)	PUNCT
bptjm-23	316	33	.	.	PUNCT
bptjm-23	317	1	int	int	PROPN
bptjm-23	318	1	j	j	PROPN
bptjm-23	318	2	chron	chron	NOUN
bptjm-23	318	3	obstruct	obstruct	VERB
bptjm-23	318	4	pulmon	pulmon	PROPN
bptjm-23	318	5	dis	dis	PROPN
bptjm-23	318	6	.	.	PUNCT
bptjm-23	319	1	2018;13:399	2018;13:399	NUM
bptjm-23	319	2	-	-	SYM
bptjm-23	319	3	407	407	NUM
bptjm-23	319	4	.	.	PUNCT
bptjm-23	320	1	published	publish	VERB
bptjm-23	320	2	2018	2018	NUM
bptjm-23	320	3	jan	jan	PROPN
bptjm-23	320	4	30	30	NUM
bptjm-23	320	5	.	.	PUNCT
bptjm-23	320	6	doi:10.2147	doi:10.2147	NOUN
bptjm-23	320	7	/	/	SYM
bptjm-23	320	8	copd.s144312	copd.s144312	PROPN
bptjm-23	320	9	24	24	NUM
bptjm-23	320	10	.	.	PUNCT
bptjm-23	321	1	sanders	sanders	PROPN
bptjm-23	321	2	n	n	CCONJ
bptjm-23	321	3	,	,	PUNCT
bptjm-23	321	4	rudolph	rudolph	PROPN
bptjm-23	321	5	c	c	PROPN
bptjm-23	321	6	,	,	PUNCT
bptjm-23	321	7	braeckmans	braeckmans	PROPN
bptjm-23	321	8	k	k	X
bptjm-23	321	9	,	,	PUNCT
bptjm-23	321	10	de	de	PROPN
bptjm-23	321	11	smedt	smedt	PROPN
bptjm-23	321	12	sc	sc	PROPN
bptjm-23	321	13	,	,	PUNCT
bptjm-23	321	14	demeester	demeester	NOUN
bptjm-23	321	15	j.	j.	PROPN
bptjm-23	321	16	extracellular	extracellular	PROPN
bptjm-23	321	17	barriers	barrier	NOUN
bptjm-23	321	18	in	in	ADP
bptjm-23	321	19	respiratory	respiratory	ADJ
bptjm-23	321	20	gene	gene	NOUN
bptjm-23	321	21	therapy	therapy	NOUN
bptjm-23	321	22	.	.	PUNCT
bptjm-23	322	1	adv	adv	PROPN
bptjm-23	322	2	drug	drug	PROPN
bptjm-23	322	3	deliv	deliv	PROPN
bptjm-23	322	4	rev	rev	VERB
bptjm-23	322	5	.	.	PUNCT
bptjm-23	323	1	2009;61(2):115	2009;61(2):115	PROPN
bptjm-23	323	2	-	-	SYM
bptjm-23	323	3	127	127	NUM
bptjm-23	323	4	.	.	PUNCT
bptjm-23	324	1	doi:10.1016	doi:10.1016	PROPN
bptjm-23	324	2	/	/	SYM
bptjm-23	324	3	j.addr.2008.09.011	j.addr.2008.09.011	PROPN
bptjm-23	324	4	25	25	NUM
bptjm-23	324	5	.	.	PUNCT
bptjm-23	324	6	de	de	PROPN
bptjm-23	324	7	boer	boer	PROPN
bptjm-23	324	8	,	,	PUNCT
bptjm-23	324	9	w.	w.	PROPN
bptjm-23	324	10	i.	i.	PROPN
bptjm-23	324	11	,	,	PUNCT
bptjm-23	324	12	hau	hau	PROPN
bptjm-23	324	13	,	,	PUNCT
bptjm-23	324	14	c.	c.	PROPN
bptjm-23	324	15	m.	m.	PROPN
bptjm-23	324	16	,	,	PUNCT
bptjm-23	324	17	van	van	PROPN
bptjm-23	324	18	schadewijk	schadewijk	PROPN
bptjm-23	324	19	,	,	PUNCT
bptjm-23	324	20	a.	a.	PROPN
bptjm-23	324	21	,	,	PUNCT
bptjm-23	324	22	stolk	stolk	PROPN
bptjm-23	324	23	,	,	PUNCT
bptjm-23	324	24	j.	j.	PROPN
bptjm-23	324	25	,	,	PUNCT
bptjm-23	324	26	van	van	PROPN
bptjm-23	324	27	krieken	krieken	PROPN
bptjm-23	324	28	,	,	PUNCT
bptjm-23	324	29	j.	j.	PROPN
bptjm-23	324	30	h.	h.	PROPN
bptjm-23	324	31	,	,	PUNCT
bptjm-23	324	32	&	&	CCONJ
bptjm-23	324	33	hiemstra	hiemstra	PROPN
bptjm-23	324	34	,	,	PUNCT
bptjm-23	324	35	p.	p.	PROPN
bptjm-23	324	36	s.	s.	PROPN
bptjm-23	324	37	(	(	PUNCT
bptjm-23	324	38	2006	2006	NUM
bptjm-23	324	39	)	)	PUNCT
bptjm-23	324	40	.	.	PUNCT
bptjm-23	325	1	expression	expression	NOUN
bptjm-23	325	2	of	of	ADP
bptjm-23	325	3	epidermal	epidermal	ADJ
bptjm-23	325	4	growth	growth	NOUN
bptjm-23	325	5	factors	factor	NOUN
bptjm-23	325	6	and	and	CCONJ
bptjm-23	325	7	their	their	PRON
bptjm-23	325	8	receptors	receptor	NOUN
bptjm-23	325	9	in	in	ADP
bptjm-23	325	10	the	the	DET
bptjm-23	325	11	bronchial	bronchial	ADJ
bptjm-23	325	12	epithelium	epithelium	NOUN
bptjm-23	325	13	of	of	ADP
bptjm-23	325	14	subjects	subject	NOUN
bptjm-23	325	15	with	with	ADP
bptjm-23	325	16	chronic	chronic	ADJ
bptjm-23	325	17	obstructive	obstructive	ADJ
bptjm-23	325	18	pulmonary	pulmonary	ADJ
bptjm-23	325	19	disease	disease	NOUN
bptjm-23	325	20	.	.	PUNCT
bptjm-23	326	1	am	be	AUX
bptjm-23	326	2	j	j	PROPN
bptjm-23	326	3	clin	clin	PROPN
bptjm-23	326	4	path	path	NOUN
bptjm-23	326	5	.	.	PUNCT
bptjm-23	327	1	125(2	125(2	NUM
bptjm-23	327	2	)	)	PUNCT
bptjm-23	327	3	,	,	PUNCT
bptjm-23	327	4	184–192	184–192	NUM
bptjm-23	327	5	.	.	PUNCT
bptjm-23	327	6	https://doi.org/10.1309/w1ax-kgt7-ua37-x257	https://doi.org/10.1309/w1ax-kgt7-ua37-x257	NOUN
bptjm-23	327	7	26	26	NUM
bptjm-23	327	8	.	.	PUNCT
bptjm-23	328	1	wang	wang	PROPN
bptjm-23	328	2	,	,	PUNCT
bptjm-23	328	3	c.	c.	PROPN
bptjm-23	328	4	,	,	PUNCT
bptjm-23	328	5	zhou	zhou	PROPN
bptjm-23	328	6	,	,	PUNCT
bptjm-23	328	7	j.	j.	PROPN
bptjm-23	328	8	,	,	PUNCT
bptjm-23	328	9	wang	wang	PROPN
bptjm-23	328	10	,	,	PUNCT
bptjm-23	328	11	j.	j.	PROPN
bptjm-23	328	12	et	et	PROPN
bptjm-23	328	13	al	al	PROPN
bptjm-23	328	14	.	.	PROPN
bptjm-23	328	15	progress	progress	NOUN
bptjm-23	328	16	in	in	ADP
bptjm-23	328	17	the	the	DET
bptjm-23	328	18	mechanism	mechanism	NOUN
bptjm-23	328	19	and	and	CCONJ
bptjm-23	328	20	targeted	target	VERB
bptjm-23	328	21	drug	drug	NOUN
bptjm-23	328	22	therapy	therapy	NOUN
bptjm-23	328	23	for	for	ADP
bptjm-23	328	24	copd	copd	NOUN
bptjm-23	328	25	.	.	PUNCT
bptjm-23	329	1	sig	sig	PRON
bptjm-23	329	2	transduct	transduct	NOUN
bptjm-23	329	3	target	target	NOUN
bptjm-23	329	4	ther	ther	ADV
bptjm-23	329	5	.	.	PUNCT
bptjm-23	330	1	5	5	NUM
bptjm-23	330	2	,	,	PUNCT
bptjm-23	330	3	248	248	NUM
bptjm-23	330	4	(	(	PUNCT
bptjm-23	330	5	2020	2020	NUM
bptjm-23	330	6	)	)	PUNCT
bptjm-23	330	7	.	.	PUNCT
bptjm-23	331	1	https://doi.org/10.1038/s41392-020-00345-x	https://doi.org/10.1038/s41392-020-00345-x	PROPN
bptjm-23	331	2	27	27	NUM
bptjm-23	331	3	.	.	PUNCT
bptjm-23	332	1	khan	khan	PROPN
bptjm-23	332	2	of	of	ADP
bptjm-23	332	3	,	,	PUNCT
bptjm-23	332	4	zaia	zaia	PROPN
bptjm-23	332	5	ew	ew	PROPN
bptjm-23	332	6	,	,	PUNCT
bptjm-23	332	7	jhunjhunwala	jhunjhunwala	PROPN
bptjm-23	332	8	s	s	PROPN
bptjm-23	332	9	,	,	PUNCT
bptjm-23	332	10	et	et	PROPN
bptjm-23	332	11	al	al	PROPN
bptjm-23	332	12	.	.	PUNCT
bptjm-23	332	13	dendrimer	dendrimer	PROPN
bptjm-23	332	14	-	-	PUNCT
bptjm-23	332	15	inspired	inspire	VERB
bptjm-23	332	16	nanomaterials	nanomaterial	NOUN
bptjm-23	332	17	for	for	ADP
bptjm-23	332	18	the	the	DET
bptjm-23	332	19	in	in	ADP
bptjm-23	332	20	vivo	vivo	ADJ
bptjm-23	332	21	delivery	delivery	NOUN
bptjm-23	332	22	of	of	ADP
bptjm-23	332	23	sirna	sirna	PROPN
bptjm-23	332	24	to	to	ADP
bptjm-23	332	25	lung	lung	NOUN
bptjm-23	332	26	vasculature	vasculature	NOUN
bptjm-23	332	27	.	.	PUNCT
bptjm-23	333	1	nano	nano	PROPN
bptjm-23	333	2	lett	lett	PROPN
bptjm-23	333	3	.	.	PUNCT
bptjm-23	334	1	2015;15(5):3008	2015;15(5):3008	PROPN
bptjm-23	334	2	-	-	SYM
bptjm-23	334	3	3016	3016	NUM
bptjm-23	334	4	.	.	PUNCT
bptjm-23	335	1	doi:10.1021	doi:10.1021	PROPN
bptjm-23	335	2	/	/	SYM
bptjm-23	335	3	nl5048972	nl5048972	PROPN
bptjm-23	335	4	28	28	NUM
bptjm-23	335	5	.	.	PUNCT
bptjm-23	336	1	ryan	ryan	PROPN
bptjm-23	336	2	gm	gm	PROPN
bptjm-23	336	3	,	,	PUNCT
bptjm-23	336	4	kaminskas	kaminskas	PROPN
bptjm-23	336	5	lm	lm	PROPN
bptjm-23	336	6	,	,	PUNCT
bptjm-23	336	7	kelly	kelly	PROPN
bptjm-23	336	8	bd	bd	PROPN
bptjm-23	336	9	,	,	PUNCT
bptjm-23	336	10	owen	owen	PROPN
bptjm-23	336	11	dj	dj	PROPN
bptjm-23	336	12	,	,	PUNCT
bptjm-23	336	13	mcintosh	mcintosh	PROPN
bptjm-23	336	14	mp	mp	PROPN
bptjm-23	336	15	,	,	PUNCT
bptjm-23	336	16	porter	porter	PROPN
bptjm-23	336	17	cj	cj	NOUN
bptjm-23	336	18	.	.	PUNCT
bptjm-23	337	1	pulmonary	pulmonary	ADJ
bptjm-23	337	2	administration	administration	NOUN
bptjm-23	337	3	of	of	ADP
bptjm-23	337	4	pegylated	pegylate	VERB
bptjm-23	337	5	polylysine	polylysine	NOUN
bptjm-23	337	6	dendrimers	dendrimer	NOUN
bptjm-23	337	7	:	:	PUNCT
bptjm-23	337	8	absorption	absorption	NOUN
bptjm-23	337	9	from	from	ADP
bptjm-23	337	10	the	the	DET
bptjm-23	337	11	lung	lung	NOUN
bptjm-23	337	12	versus	versus	ADP
bptjm-23	337	13	retention	retention	NOUN
bptjm-23	337	14	within	within	ADP
bptjm-23	337	15	the	the	DET
bptjm-23	337	16	lung	lung	NOUN
bptjm-23	337	17	is	be	AUX
bptjm-23	337	18	highly	highly	ADV
bptjm-23	337	19	size	size	NOUN
bptjm-23	337	20	-	-	PUNCT
bptjm-23	337	21	dependent	dependent	ADJ
bptjm-23	337	22	.	.	PUNCT
bptjm-23	338	1	mol	mol	ADP
bptjm-23	338	2	pharm	pharm	PROPN
bptjm-23	338	3	.	.	PUNCT
bptjm-23	339	1	2013;10(8):2986	2013;10(8):2986	NUM
bptjm-23	339	2	-	-	SYM
bptjm-23	339	3	2995	2995	NUM
bptjm-23	339	4	.	.	PUNCT
bptjm-23	340	1	berkeley	berkeley	PROPN
bptjm-23	340	2	pharma	pharma	PROPN
bptjm-23	340	3	tech	tech	PROPN
bptjm-23	340	4	journal	journal	NOUN
bptjm-23	340	5	of	of	ADP
bptjm-23	340	6	medicine	medicine	NOUN
bptjm-23	340	7	|	|	ADV
bptjm-23	340	8	78	78	NUM
bptjm-23	340	9	doi:10.1021	doi:10.1021	ADJ
bptjm-23	340	10	/	/	SYM
bptjm-23	340	11	mp400091n	mp400091n	PROPN
bptjm-23	340	12	29	29	NUM
bptjm-23	340	13	.	.	PUNCT
bptjm-23	341	1	bharatwaj	bharatwaj	PROPN
bptjm-23	341	2	b	b	PROPN
bptjm-23	341	3	,	,	PUNCT
bptjm-23	341	4	mohammad	mohammad	PROPN
bptjm-23	341	5	ak	ak	PROPN
bptjm-23	341	6	,	,	PUNCT
bptjm-23	341	7	dimovski	dimovski	VERB
bptjm-23	341	8	r	r	NOUN
bptjm-23	341	9	,	,	PUNCT
bptjm-23	341	10	et	et	PROPN
bptjm-23	341	11	al	al	PROPN
bptjm-23	341	12	.	.	PROPN
bptjm-23	342	1	dendrimer	dendrimer	PROPN
bptjm-23	342	2	nanocarriers	nanocarrier	NOUN
bptjm-23	342	3	for	for	ADP
bptjm-23	342	4	transport	transport	NOUN
bptjm-23	342	5	modulation	modulation	NOUN
bptjm-23	342	6	across	across	ADP
bptjm-23	342	7	models	model	NOUN
bptjm-23	342	8	of	of	ADP
bptjm-23	342	9	the	the	DET
bptjm-23	342	10	pulmonary	pulmonary	ADJ
bptjm-23	342	11	epithelium	epithelium	NOUN
bptjm-23	342	12	.	.	PUNCT
bptjm-23	343	1	mol	mol	ADP
bptjm-23	343	2	pharm	pharm	PROPN
bptjm-23	343	3	.	.	PUNCT
bptjm-23	344	1	2015;12(3):826	2015;12(3):826	NUM
bptjm-23	344	2	-	-	PUNCT
bptjm-23	344	3	838	838	NUM
bptjm-23	344	4	.	.	PUNCT
bptjm-23	345	1	doi:10.1021	doi:10.1021	PROPN
bptjm-23	345	2	/	/	SYM
bptjm-23	345	3	mp500662z	mp500662z	PROPN
bptjm-23	345	4	30	30	NUM
bptjm-23	345	5	.	.	PUNCT
bptjm-23	346	1	cemazar	cemazar	PROPN
bptjm-23	346	2	m	m	PROPN
bptjm-23	346	3	,	,	PUNCT
bptjm-23	346	4	golzio	golzio	VERB
bptjm-23	346	5	m	m	PROPN
bptjm-23	346	6	,	,	PUNCT
bptjm-23	346	7	sersa	sersa	PROPN
bptjm-23	346	8	g	g	PROPN
bptjm-23	346	9	,	,	PUNCT
bptjm-23	346	10	et	et	PROPN
bptjm-23	346	11	al	al	PROPN
bptjm-23	346	12	.	.	PUNCT
bptjm-23	346	13	control	control	PROPN
bptjm-23	346	14	by	by	ADP
bptjm-23	346	15	pulse	pulse	NOUN
bptjm-23	346	16	parameters	parameter	NOUN
bptjm-23	346	17	of	of	ADP
bptjm-23	346	18	dna	dna	PROPN
bptjm-23	346	19	electrotransfer	electrotransfer	VERB
bptjm-23	346	20	into	into	ADP
bptjm-23	346	21	solid	solid	ADJ
bptjm-23	346	22	tumors	tumor	NOUN
bptjm-23	346	23	in	in	ADP
bptjm-23	346	24	mice	mouse	NOUN
bptjm-23	346	25	.	.	PUNCT
bptjm-23	347	1	gene	gene	NOUN
bptjm-23	347	2	ther	ther	ADV
bptjm-23	347	3	.	.	PUNCT
bptjm-23	348	1	2009;16(5):635	2009;16(5):635	PROPN
bptjm-23	348	2	-	-	PUNCT
bptjm-23	348	3	644	644	NUM
bptjm-23	348	4	.	.	PUNCT
bptjm-23	349	1	doi:10.1038	doi:10.1038	NOUN
bptjm-23	349	2	/	/	SYM
bptjm-23	349	3	gt.2009.10	gt.2009.10	PROPN
bptjm-23	349	4	31	31	NUM
bptjm-23	349	5	.	.	PUNCT
bptjm-23	350	1	young	young	ADJ
bptjm-23	350	2	jl	jl	PROPN
bptjm-23	350	3	,	,	PUNCT
bptjm-23	350	4	dean	dean	PROPN
bptjm-23	350	5	da	da	PROPN
bptjm-23	350	6	.	.	PUNCT
bptjm-23	350	7	chapter	chapter	NOUN
bptjm-23	350	8	three	three	NUM
bptjm-23	350	9	electroporation	electroporation	NOUN
bptjm-23	350	10	-	-	PUNCT
bptjm-23	350	11	mediated	mediate	VERB
bptjm-23	350	12	gene	gene	NOUN
bptjm-23	350	13	delivery	delivery	NOUN
bptjm-23	350	14	.	.	PUNCT
bptjm-23	351	1	in	in	ADP
bptjm-23	351	2	:	:	PUNCT
bptjm-23	351	3	huang	huang	PROPN
bptjm-23	351	4	l	l	PROPN
bptjm-23	351	5	,	,	PUNCT
bptjm-23	351	6	liu	liu	PROPN
bptjm-23	351	7	d	d	PROPN
bptjm-23	351	8	,	,	PUNCT
bptjm-23	351	9	wagner	wagner	PROPN
bptjm-23	351	10	e	e	PROPN
bptjm-23	351	11	,	,	PUNCT
bptjm-23	351	12	eds	eds	PROPN
bptjm-23	351	13	.	.	PUNCT
bptjm-23	351	14	adv	adv	PROPN
bptjm-23	351	15	gen	gen	PROPN
bptjm-23	351	16	.	.	PROPN
bptjm-23	351	17	vol	vol	NOUN
bptjm-23	351	18	89	89	NUM
bptjm-23	351	19	.	.	PUNCT
bptjm-23	352	1	academic	academic	ADJ
bptjm-23	352	2	press	press	NOUN
bptjm-23	352	3	;	;	PUNCT
bptjm-23	352	4	2015:49	2015:49	NUM
bptjm-23	352	5	-	-	SYM
bptjm-23	352	6	88	88	NUM
bptjm-23	352	7	.	.	PUNCT
bptjm-23	353	1	doi:10.1016	doi:10.1016	PROPN
bptjm-23	353	2	/	/	SYM
bptjm-23	353	3	bs.adgen.2014.10.003	bs.adgen.2014.10.003	PROPN
bptjm-23	353	4	32	32	NUM
bptjm-23	353	5	.	.	PUNCT
bptjm-23	354	1	bulcha	bulcha	PROPN
bptjm-23	354	2	,	,	PUNCT
bptjm-23	354	3	j.t	j.t	PROPN
bptjm-23	354	4	.	.	PROPN
bptjm-23	354	5	,	,	PUNCT
bptjm-23	354	6	wang	wang	PROPN
bptjm-23	354	7	,	,	PUNCT
bptjm-23	354	8	y.	y.	PROPN
bptjm-23	354	9	,	,	PUNCT
bptjm-23	354	10	ma	ma	PROPN
bptjm-23	354	11	,	,	PUNCT
bptjm-23	354	12	h.	h.	PROPN
bptjm-23	354	13	et	et	PROPN
bptjm-23	354	14	al	al	PROPN
bptjm-23	354	15	.	.	PROPN
bptjm-23	354	16	viral	viral	ADJ
bptjm-23	354	17	vector	vector	NOUN
bptjm-23	354	18	platforms	platform	NOUN
bptjm-23	354	19	within	within	ADP
bptjm-23	354	20	the	the	DET
bptjm-23	354	21	gene	gene	NOUN
bptjm-23	354	22	therapy	therapy	NOUN
bptjm-23	354	23	landscape	landscape	NOUN
bptjm-23	354	24	.	.	PUNCT
bptjm-23	355	1	sig	sig	PRON
bptjm-23	355	2	transduct	transduct	NOUN
bptjm-23	355	3	target	target	NOUN
bptjm-23	355	4	ther	ther	ADV
bptjm-23	355	5	.	.	PUNCT
bptjm-23	356	1	6	6	NUM
bptjm-23	356	2	,	,	PUNCT
bptjm-23	356	3	53	53	NUM
bptjm-23	356	4	(	(	PUNCT
bptjm-23	356	5	2021	2021	NUM
bptjm-23	356	6	)	)	PUNCT
bptjm-23	356	7	.	.	PUNCT
bptjm-23	357	1	https://doi.org/10.1038/s41392-021-00487-6	https://doi.org/10.1038/s41392-021-00487-6	PROPN
bptjm-23	357	2	33	33	NUM
bptjm-23	357	3	.	.	PUNCT
bptjm-23	358	1	hage	hage	PROPN
bptjm-23	358	2	e.	e.	PROPN
bptjm-23	358	3	,	,	PUNCT
bptjm-23	358	4	gerd	gerd	PROPN
bptjm-23	358	5	liebert	liebert	PROPN
bptjm-23	358	6	u.	u.	PROPN
bptjm-23	358	7	,	,	PUNCT
bptjm-23	358	8	bergs	bergs	PROPN
bptjm-23	358	9	s.	s.	PROPN
bptjm-23	358	10	,	,	PUNCT
bptjm-23	358	11	ganzenmueller	ganzenmueller	PROPN
bptjm-23	358	12	t.	t.	PROPN
bptjm-23	358	13	,	,	PUNCT
bptjm-23	358	14	heim	heim	PROPN
bptjm-23	358	15	a.	a.	PROPN
bptjm-23	358	16	(	(	PUNCT
bptjm-23	358	17	2015	2015	NUM
bptjm-23	358	18	)	)	PUNCT
bptjm-23	358	19	.	.	PUNCT
bptjm-23	359	1	human	human	ADJ
bptjm-23	359	2	mastadenovirus	mastadenovirus	PROPN
bptjm-23	359	3	type	type	NOUN
bptjm-23	359	4	70	70	NUM
bptjm-23	359	5	:	:	PUNCT
bptjm-23	359	6	a	a	DET
bptjm-23	359	7	novel	novel	NOUN
bptjm-23	359	8	,	,	PUNCT
bptjm-23	359	9	multiple	multiple	ADJ
bptjm-23	359	10	recombinant	recombinant	ADJ
bptjm-23	359	11	species	specie	NOUN
bptjm-23	359	12	d	d	NOUN
bptjm-23	359	13	mastadenovirus	mastadenovirus	NOUN
bptjm-23	359	14	isolated	isolate	VERB
bptjm-23	359	15	from	from	ADP
bptjm-23	359	16	diarrhoeal	diarrhoeal	ADJ
bptjm-23	359	17	feces	fece	NOUN
bptjm-23	359	18	of	of	ADP
bptjm-23	359	19	a	a	DET
bptjm-23	359	20	haematopoietic	haematopoietic	ADJ
bptjm-23	359	21	stem	stem	NOUN
bptjm-23	359	22	cell	cell	NOUN
bptjm-23	359	23	transplantation	transplantation	NOUN
bptjm-23	359	24	recipient	recipient	NOUN
bptjm-23	359	25	.	.	PUNCT
bptjm-23	360	1	j.	j.	PROPN
bptjm-23	360	2	gen	gen	PROPN
bptjm-23	360	3	.	.	PROPN
bptjm-23	360	4	virol	virol	PROPN
bptjm-23	360	5	.	.	PUNCT
bptjm-23	361	1	96	96	NUM
bptjm-23	361	2	,	,	PUNCT
bptjm-23	361	3	2734–2742	2734–2742	NUM
bptjm-23	361	4	.	.	PUNCT
bptjm-23	362	1	10.1099	10.1099	NUM
bptjm-23	362	2	/	/	SYM
bptjm-23	362	3	vir.0.000196	vir.0.000196	NOUN
bptjm-23	362	4	34	34	NUM
bptjm-23	362	5	.	.	PUNCT
bptjm-23	363	1	campos	campos	PROPN
bptjm-23	363	2	sk	sk	PROPN
bptjm-23	363	3	,	,	PUNCT
bptjm-23	363	4	barry	barry	PROPN
bptjm-23	363	5	ma	ma	PROPN
bptjm-23	363	6	.	.	PROPN
bptjm-23	364	1	current	current	ADJ
bptjm-23	364	2	advances	advance	NOUN
bptjm-23	364	3	and	and	CCONJ
bptjm-23	364	4	future	future	ADJ
bptjm-23	364	5	challenges	challenge	NOUN
bptjm-23	364	6	in	in	ADP
bptjm-23	364	7	adenoviral	adenoviral	ADJ
bptjm-23	364	8	vector	vector	NOUN
bptjm-23	364	9	biology	biology	NOUN
bptjm-23	364	10	and	and	CCONJ
bptjm-23	364	11	targeting	targeting	NOUN
bptjm-23	364	12	.	.	PUNCT
bptjm-23	365	1	curr	curr	PROPN
bptjm-23	365	2	gene	gene	PROPN
bptjm-23	365	3	ther	ther	ADV
bptjm-23	365	4	.	.	PUNCT
bptjm-23	366	1	2007;7(3):189	2007;7(3):189	X
bptjm-23	366	2	-	-	SYM
bptjm-23	366	3	204	204	NUM
bptjm-23	366	4	.	.	PUNCT
bptjm-23	367	1	doi:10.2174/156652307780859062	doi:10.2174/156652307780859062	NOUN
bptjm-23	368	1	35	35	NUM
bptjm-23	368	2	.	.	PUNCT
bptjm-23	369	1	san	san	PROPN
bptjm-23	369	2	martín	martín	PROPN
bptjm-23	369	3	c.	c.	PROPN
bptjm-23	369	4	latest	late	ADJ
bptjm-23	369	5	insights	insight	NOUN
bptjm-23	369	6	on	on	ADP
bptjm-23	369	7	adenovirus	adenovirus	NOUN
bptjm-23	369	8	structure	structure	NOUN
bptjm-23	369	9	and	and	CCONJ
bptjm-23	369	10	assembly	assembly	NOUN
bptjm-23	369	11	[	[	X
bptjm-23	369	12	published	publish	VERB
bptjm-23	369	13	correction	correction	NOUN
bptjm-23	369	14	appears	appear	VERB
bptjm-23	369	15	in	in	ADP
bptjm-23	369	16	viruses	virus	NOUN
bptjm-23	369	17	.	.	PUNCT
bptjm-23	370	1	2012;4(12):3952	2012;4(12):3952	NUM
bptjm-23	370	2	]	]	PUNCT
bptjm-23	370	3	.	.	PUNCT
bptjm-23	371	1	viruses	virus	NOUN
bptjm-23	371	2	.	.	PUNCT
bptjm-23	372	1	2012;4(5):847	2012;4(5):847	X
bptjm-23	372	2	-	-	PUNCT
bptjm-23	372	3	877	877	NUM
bptjm-23	372	4	.	.	PUNCT
bptjm-23	373	1	doi:10.3390	doi:10.3390	NOUN
bptjm-23	373	2	/	/	SYM
bptjm-23	373	3	v4050847	v4050847	NOUN
bptjm-23	373	4	36	36	NUM
bptjm-23	373	5	.	.	PUNCT
bptjm-23	374	1	lee	lee	PROPN
bptjm-23	374	2	d	d	PROPN
bptjm-23	374	3	,	,	PUNCT
bptjm-23	374	4	liu	liu	PROPN
bptjm-23	374	5	j	j	PROPN
bptjm-23	374	6	,	,	PUNCT
bptjm-23	374	7	junn	junn	PROPN
bptjm-23	374	8	hj	hj	PROPN
bptjm-23	374	9	et	et	PROPN
bptjm-23	374	10	al	al	PROPN
bptjm-23	374	11	.	.	PUNCT
bptjm-23	375	1	no	no	PRON
bptjm-23	375	2	more	more	ADJ
bptjm-23	375	3	helper	helper	NOUN
bptjm-23	375	4	adenovirus	adenovirus	NOUN
bptjm-23	375	5	:	:	PUNCT
bptjm-23	375	6	production	production	NOUN
bptjm-23	375	7	of	of	ADP
bptjm-23	375	8	gutless	gutless	ADJ
bptjm-23	375	9	adenovirus	adenovirus	NOUN
bptjm-23	375	10	(	(	PUNCT
bptjm-23	375	11	glad	glad	ADJ
bptjm-23	375	12	)	)	PUNCT
bptjm-23	375	13	free	free	ADJ
bptjm-23	375	14	of	of	ADP
bptjm-23	375	15	adenovirus	adenovirus	NOUN
bptjm-23	375	16	and	and	CCONJ
bptjm-23	375	17	replication	replication	NOUN
bptjm-23	375	18	-	-	PUNCT
bptjm-23	375	19	competent	competent	ADJ
bptjm-23	375	20	adenovirus	adenovirus	NOUN
bptjm-23	375	21	(	(	PUNCT
bptjm-23	375	22	rca	rca	PROPN
bptjm-23	375	23	)	)	PUNCT
bptjm-23	375	24	contaminants	contaminant	NOUN
bptjm-23	375	25	.	.	PUNCT
bptjm-23	376	1	exp	exp	NOUN
bptjm-23	376	2	mol	mol	ADP
bptjm-23	376	3	med	med	PROPN
bptjm-23	376	4	.	.	PUNCT
bptjm-23	377	1	2019;51:1–18	2019;51:1–18	NUM
bptjm-23	377	2	.	.	PUNCT
bptjm-23	378	1	https://doi.org/10.1038/s12276-019-0334-z	https://doi.org/10.1038/s12276-019-0334-z	PROPN
bptjm-23	378	2	37	37	NUM
bptjm-23	378	3	.	.	PUNCT
bptjm-23	379	1	cao	cao	PROPN
bptjm-23	379	2	h	h	PROPN
bptjm-23	379	3	,	,	PUNCT
bptjm-23	379	4	machuca	machuca	PROPN
bptjm-23	379	5	tn	tn	PROPN
bptjm-23	379	6	,	,	PUNCT
bptjm-23	379	7	yeung	yeung	PROPN
bptjm-23	379	8	jc	jc	PROPN
bptjm-23	379	9	,	,	PUNCT
bptjm-23	379	10	et	et	PROPN
bptjm-23	379	11	al	al	PROPN
bptjm-23	379	12	.	.	PUNCT
bptjm-23	380	1	e	e	VERB
bptjm-23	380	2	�	�	PROPN
bptjm-23	380	3	cient	cient	NOUN
bptjm-23	380	4	gene	gene	NOUN
bptjm-23	380	5	delivery	delivery	NOUN
bptjm-23	380	6	to	to	ADP
bptjm-23	380	7	pig	pig	NOUN
bptjm-23	380	8	airway	airway	NOUN
bptjm-23	380	9	epithelia	epithelia	PROPN
bptjm-23	380	10	and	and	CCONJ
bptjm-23	380	11	submucosal	submucosal	NOUN
bptjm-23	380	12	glands	gland	NOUN
bptjm-23	380	13	using	use	VERB
bptjm-23	380	14	helper	helper	NOUN
bptjm-23	380	15	-	-	PUNCT
bptjm-23	380	16	dependent	dependent	ADJ
bptjm-23	380	17	adenoviral	adenoviral	ADJ
bptjm-23	380	18	vectors	vector	NOUN
bptjm-23	380	19	.	.	PUNCT
bptjm-23	381	1	mol	mol	ADP
bptjm-23	381	2	ther	ther	ADV
bptjm-23	381	3	nucleic	nucleic	ADJ
bptjm-23	381	4	acids	acid	NOUN
bptjm-23	381	5	.	.	PUNCT
bptjm-23	382	1	2013;2(10):e127	2013;2(10):e127	X
bptjm-23	382	2	.	.	PUNCT
bptjm-23	382	3	published	publish	VERB
bptjm-23	382	4	2013	2013	NUM
bptjm-23	382	5	oct	oct	NOUN
bptjm-23	382	6	8	8	NUM
bptjm-23	382	7	.	.	PUNCT
bptjm-23	382	8	doi:10.1038	doi:10.1038	NOUN
bptjm-23	382	9	/	/	SYM
bptjm-23	382	10	mtna.2013.55	mtna.2013.55	NOUN
bptjm-23	382	11	38	38	NUM
bptjm-23	382	12	.	.	PUNCT
bptjm-23	383	1	fausther	fausther	ADJ
bptjm-23	383	2	-	-	PUNCT
bptjm-23	383	3	bovendo	bovendo	NOUN
bptjm-23	383	4	h	h	NOUN
bptjm-23	383	5	,	,	PUNCT
bptjm-23	383	6	kobinger	kobinger	PROPN
bptjm-23	383	7	gp	gp	NOUN
bptjm-23	383	8	.	.	PUNCT
bptjm-23	384	1	pre	pre	VERB
bptjm-23	384	2	-	-	ADJ
bptjm-23	384	3	existing	exist	VERB
bptjm-23	384	4	immunity	immunity	NOUN
bptjm-23	384	5	against	against	ADP
bptjm-23	384	6	ad	ad	NOUN
bptjm-23	384	7	vectors	vector	NOUN
bptjm-23	384	8	:	:	PUNCT
bptjm-23	384	9	humoral	humoral	ADJ
bptjm-23	384	10	,	,	PUNCT
bptjm-23	384	11	cellular	cellular	ADJ
bptjm-23	384	12	,	,	PUNCT
bptjm-23	384	13	and	and	CCONJ
bptjm-23	384	14	innate	innate	ADJ
bptjm-23	384	15	response	response	NOUN
bptjm-23	384	16	,	,	PUNCT
bptjm-23	384	17	what	what	PRON
bptjm-23	384	18	's	be	AUX
bptjm-23	384	19	important	important	ADJ
bptjm-23	384	20	?	?	PUNCT
bptjm-23	384	21	.	.	PUNCT
bptjm-23	385	1	hum	hum	PROPN
bptjm-23	385	2	vaccin	vaccin	PROPN
bptjm-23	385	3	immunother	immunother	PROPN
bptjm-23	385	4	.	.	PUNCT
bptjm-23	386	1	2014;10(10):2875	2014;10(10):2875	PROPN
bptjm-23	386	2	-	-	SYM
bptjm-23	386	3	2884	2884	NUM
bptjm-23	386	4	.	.	PUNCT
bptjm-23	387	1	doi:10.4161	doi:10.4161	PROPN
bptjm-23	387	2	/	/	SYM
bptjm-23	387	3	hv.29594	hv.29594	PROPN
bptjm-23	387	4	39	39	NUM
bptjm-23	387	5	.	.	PUNCT
bptjm-23	388	1	bates	bates	PROPN
bptjm-23	388	2	ea	ea	PROPN
bptjm-23	388	3	,	,	PUNCT
bptjm-23	388	4	counsell	counsell	PROPN
bptjm-23	388	5	jr	jr	PROPN
bptjm-23	388	6	,	,	PUNCT
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bptjm-23	388	9	,	,	PUNCT
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bptjm-23	388	22	,	,	PUNCT
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bptjm-23	388	25	,	,	PUNCT
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bptjm-23	389	13	a	a	DET
bptjm-23	389	14	vector	vector	NOUN
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bptjm-23	389	16	therapeutic	therapeutic	ADJ
bptjm-23	389	17	applications	application	NOUN
bptjm-23	389	18	.	.	PUNCT
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bptjm-23	390	2	.	.	PUNCT
bptjm-23	391	1	2021;13(8):1483	2021;13(8):1483	NUM
bptjm-23	391	2	.	.	PUNCT
bptjm-23	392	1	https://doi.org/10.3390/v13081483	https://doi.org/10.3390/v13081483	NUM
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bptjm-23	392	3	.	.	PUNCT
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bptjm-23	393	13	-	-	PUNCT
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bptjm-23	393	15	adenoviral	adenoviral	ADJ
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bptjm-23	393	17	in	in	ADP
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bptjm-23	393	19	-	-	PUNCT
bptjm-23	393	20	cas9	cas9	NOUN
bptjm-23	393	21	-	-	PUNCT
bptjm-23	393	22	mediated	mediate	VERB
bptjm-23	393	23	lung	lung	NOUN
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bptjm-23	393	25	therapy	therapy	NOUN
bptjm-23	393	26	.	.	PUNCT
bptjm-23	394	1	cell	cell	NOUN
bptjm-23	394	2	biosci	biosci	PROPN
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bptjm-23	395	1	2021;11(145	2021;11(145	NUM
bptjm-23	395	2	)	)	PUNCT
bptjm-23	395	3	.	.	PUNCT
bptjm-23	396	1	https://doi.org/10.1186/s13578-021-00662-w	https://doi.org/10.1186/s13578-021-00662-w	PROPN
bptjm-23	396	2	41	41	NUM
bptjm-23	396	3	.	.	PUNCT
bptjm-23	397	1	cao	cao	PROPN
bptjm-23	397	2	h	h	PROPN
bptjm-23	397	3	,	,	PUNCT
bptjm-23	397	4	ouyang	ouyang	PROPN
bptjm-23	397	5	h	h	PROPN
bptjm-23	397	6	,	,	PUNCT
bptjm-23	397	7	grasemann	grasemann	PROPN
bptjm-23	397	8	h	h	NOUN
bptjm-23	397	9	,	,	PUNCT
bptjm-23	397	10	et	et	PROPN
bptjm-23	397	11	al	al	PROPN
bptjm-23	397	12	.	.	PROPN
bptjm-23	397	13	transducing	transducing	PROPN
bptjm-23	397	14	airway	airway	PROPN
bptjm-23	397	15	basal	basal	VERB
bptjm-23	397	16	cells	cell	NOUN
bptjm-23	397	17	with	with	ADP
bptjm-23	397	18	a	a	DET
bptjm-23	397	19	helper	helper	NOUN
bptjm-23	397	20	-	-	PUNCT
bptjm-23	397	21	dependent	dependent	ADJ
bptjm-23	397	22	adenoviral	adenoviral	ADJ
bptjm-23	397	23	vector	vector	NOUN
bptjm-23	397	24	for	for	ADP
bptjm-23	397	25	lung	lung	NOUN
bptjm-23	397	26	gene	gene	NOUN
bptjm-23	397	27	therapy	therapy	NOUN
bptjm-23	397	28	.	.	PUNCT
bptjm-23	398	1	hum	hum	PROPN
bptjm-23	398	2	gene	gene	PROPN
bptjm-23	398	3	ther	ther	ADV
bptjm-23	398	4	.	.	PUNCT
bptjm-23	399	1	2018;29(6):643	2018;29(6):643	NOUN
bptjm-23	399	2	-	-	SYM
bptjm-23	399	3	652	652	NUM
bptjm-23	399	4	.	.	PUNCT
bptjm-23	399	5	doi:10.1089	doi:10.1089	NOUN
bptjm-23	399	6	/	/	SYM
bptjm-23	399	7	hum.2017.201	hum.2017.201	PROPN
bptjm-23	399	8	42	42	NUM
bptjm-23	399	9	.	.	PUNCT
bptjm-23	400	1	wu	wu	PROPN
bptjm-23	400	2	z	z	PROPN
bptjm-23	400	3	,	,	PUNCT
bptjm-23	400	4	yang	yang	PROPN
bptjm-23	400	5	h	h	PROPN
bptjm-23	400	6	,	,	PUNCT
bptjm-23	400	7	colosi	colosi	NOUN
bptjm-23	400	8	p.	p.	NOUN
bptjm-23	400	9	e	e	NOUN
bptjm-23	400	10	�	�	PROPN
bptjm-23	400	11	ect	ect	VERB
bptjm-23	400	12	of	of	ADP
bptjm-23	400	13	genome	genome	NOUN
bptjm-23	400	14	size	size	NOUN
bptjm-23	400	15	on	on	ADP
bptjm-23	400	16	aav	aav	NOUN
bptjm-23	400	17	vector	vector	NOUN
bptjm-23	400	18	packaging	packaging	NOUN
bptjm-23	400	19	.	.	PUNCT
bptjm-23	401	1	mol	mol	ADP
bptjm-23	401	2	ther	ther	ADV
bptjm-23	401	3	.	.	PUNCT
bptjm-23	402	1	2010;18(1):80	2010;18(1):80	NUM
bptjm-23	402	2	-	-	SYM
bptjm-23	402	3	86	86	NUM
bptjm-23	402	4	.	.	PUNCT
bptjm-23	403	1	doi:10.1038	doi:10.1038	NOUN
bptjm-23	403	2	/	/	SYM
bptjm-23	403	3	mt.2009.255	mt.2009.255	PROPN
bptjm-23	403	4	43	43	NUM
bptjm-23	403	5	.	.	PUNCT
bptjm-23	404	1	allocca	allocca	PROPN
bptjm-23	404	2	m	m	PROPN
bptjm-23	404	3	,	,	PUNCT
bptjm-23	404	4	doria	doria	PROPN
bptjm-23	404	5	m	m	PROPN
bptjm-23	404	6	,	,	PUNCT
bptjm-23	404	7	petrillo	petrillo	PROPN
bptjm-23	404	8	m	m	PROPN
bptjm-23	404	9	,	,	PUNCT
bptjm-23	404	10	et	et	PROPN
bptjm-23	404	11	al	al	PROPN
bptjm-23	404	12	.	.	PROPN
bptjm-23	404	13	serotype	serotype	PROPN
bptjm-23	404	14	-	-	PUNCT
bptjm-23	404	15	dependent	dependent	ADJ
bptjm-23	404	16	packaging	packaging	NOUN
bptjm-23	404	17	of	of	ADP
bptjm-23	404	18	large	large	ADJ
bptjm-23	404	19	genes	gene	NOUN
bptjm-23	404	20	in	in	ADP
bptjm-23	404	21	adeno	adeno	NOUN
bptjm-23	404	22	-	-	PUNCT
bptjm-23	404	23	associated	associate	VERB
bptjm-23	404	24	viral	viral	ADJ
bptjm-23	404	25	vectors	vector	NOUN
bptjm-23	404	26	results	result	VERB
bptjm-23	404	27	in	in	ADP
bptjm-23	404	28	e	e	NOUN
bptjm-23	404	29	�	�	NOUN
bptjm-23	404	30	ective	ective	ADJ
bptjm-23	404	31	gene	gene	NOUN
bptjm-23	404	32	delivery	delivery	NOUN
bptjm-23	404	33	in	in	ADP
bptjm-23	404	34	mice	mouse	NOUN
bptjm-23	404	35	.	.	PUNCT
bptjm-23	405	1	j	j	PROPN
bptjm-23	405	2	clin	clin	PROPN
bptjm-23	405	3	invest	invest	PROPN
bptjm-23	405	4	.	.	PUNCT
bptjm-23	406	1	2008;118(5):1955	2008;118(5):1955	NUM
bptjm-23	406	2	-	-	SYM
bptjm-23	406	3	1964	1964	NUM
bptjm-23	406	4	.	.	PUNCT
bptjm-23	407	1	doi:10.1172	doi:10.1172	PROPN
bptjm-23	407	2	/	/	SYM
bptjm-23	407	3	jci34316	jci34316	PROPN
bptjm-23	407	4	berkeley	berkeley	PROPN
bptjm-23	407	5	pharma	pharma	PROPN
bptjm-23	407	6	tech	tech	NOUN
bptjm-23	407	7	journal	journal	NOUN
bptjm-23	407	8	of	of	ADP
bptjm-23	407	9	medicine	medicine	NOUN
bptjm-23	407	10	|	|	ADV
bptjm-23	407	11	79	79	NUM
bptjm-23	407	12	44	44	NUM
bptjm-23	407	13	.	.	PUNCT
bptjm-23	408	1	ti	ti	X
bptjm-23	408	2	�	�	X
bptjm-23	408	3	any	any	DET
bptjm-23	408	4	m	m	PROPN
bptjm-23	408	5	,	,	PUNCT
bptjm-23	408	6	kay	kay	PROPN
bptjm-23	408	7	ma	ma	PROPN
bptjm-23	408	8	.	.	PROPN
bptjm-23	408	9	253	253	NUM
bptjm-23	408	10	.	.	PUNCT
bptjm-23	408	11	expanded	expand	VERB
bptjm-23	408	12	packaging	packaging	NOUN
bptjm-23	408	13	capacity	capacity	NOUN
bptjm-23	408	14	of	of	ADP
bptjm-23	408	15	aav	aav	NOUN
bptjm-23	408	16	by	by	ADP
bptjm-23	408	17	lumenal	lumenal	ADJ
bptjm-23	408	18	charge	charge	NOUN
bptjm-23	408	19	alteration	alteration	NOUN
bptjm-23	408	20	.	.	PUNCT
bptjm-23	409	1	mol	mol	ADP
bptjm-23	409	2	ther	ther	ADV
bptjm-23	409	3	.	.	PUNCT
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bptjm-23	410	2	:	:	PUNCT
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bptjm-23	410	4	-	-	PUNCT
bptjm-23	410	5	s100	s100	PROPN
bptjm-23	410	6	.	.	PUNCT
bptjm-23	411	1	doi:10.1016	doi:10.1016	PROPN
bptjm-23	411	2	/	/	SYM
bptjm-23	411	3	s1525	s1525	PROPN
bptjm-23	411	4	-	-	PUNCT
bptjm-23	411	5	0016(16)33062	0016(16)33062	NOUN
bptjm-23	411	6	-	-	PUNCT
bptjm-23	411	7	3	3	NUM
bptjm-23	411	8	45	45	NUM
bptjm-23	411	9	.	.	PUNCT
bptjm-23	412	1	fakhiri	fakhiri	PROPN
bptjm-23	413	1	j	j	PROPN
bptjm-23	413	2	,	,	PUNCT
bptjm-23	413	3	schneider	schneider	PROPN
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bptjm-23	413	5	,	,	PUNCT
bptjm-23	413	6	puschhof	puschhof	PROPN
bptjm-23	413	7	j	j	PROPN
bptjm-23	413	8	,	,	PUNCT
bptjm-23	413	9	et	et	PROPN
bptjm-23	413	10	al	al	PROPN
bptjm-23	413	11	.	.	PROPN
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bptjm-23	413	13	chimeric	chimeric	ADJ
bptjm-23	413	14	gene	gene	NOUN
bptjm-23	413	15	therapy	therapy	NOUN
bptjm-23	413	16	vectors	vector	NOUN
bptjm-23	413	17	based	base	VERB
bptjm-23	413	18	on	on	ADP
bptjm-23	413	19	adeno	adeno	NOUN
bptjm-23	413	20	-	-	PUNCT
bptjm-23	413	21	associated	associate	VERB
bptjm-23	413	22	virus	virus	NOUN
bptjm-23	413	23	and	and	CCONJ
bptjm-23	413	24	four	four	NUM
bptjm-23	413	25	di	di	NOUN
bptjm-23	413	26	�	�	PROPN
bptjm-23	413	27	erent	erent	NOUN
bptjm-23	413	28	mammalian	mammalian	NOUN
bptjm-23	413	29	bocaviruses	bocaviruse	NOUN
bptjm-23	413	30	.	.	PUNCT
bptjm-23	414	1	mol	mol	ADP
bptjm-23	414	2	ther	ther	PROPN
bptjm-23	414	3	methods	method	NOUN
bptjm-23	414	4	clin	clin	PROPN
bptjm-23	414	5	dev	dev	PROPN
bptjm-23	414	6	.	.	PUNCT
bptjm-23	415	1	2019;12:202	2019;12:202	NUM
bptjm-23	415	2	-	-	PUNCT
bptjm-23	415	3	222	222	NUM
bptjm-23	415	4	.	.	PUNCT
bptjm-23	416	1	published	publish	VERB
bptjm-23	416	2	2019	2019	NUM
bptjm-23	416	3	jan	jan	PROPN
bptjm-23	416	4	18	18	NUM
bptjm-23	416	5	.	.	PUNCT
bptjm-23	416	6	doi:10.1016	doi:10.1016	PROPN
bptjm-23	416	7	/	/	SYM
bptjm-23	416	8	j.omtm.2019.01.003	j.omtm.2019.01.003	PROPN
bptjm-23	416	9	46	46	NUM
bptjm-23	416	10	.	.	PUNCT
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bptjm-23	417	2	,	,	PUNCT
bptjm-23	417	3	m.	m.	NOUN
bptjm-23	417	4	,	,	PUNCT
bptjm-23	417	5	horner	horner	PROPN
bptjm-23	417	6	,	,	PUNCT
bptjm-23	417	7	a.	a.	NOUN
bptjm-23	417	8	,	,	PUNCT
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bptjm-23	417	10	,	,	PUNCT
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bptjm-23	418	2	et	et	PROPN
bptjm-23	418	3	al	al	PROPN
bptjm-23	418	4	.	.	PROPN
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bptjm-23	418	6	to	to	ADP
bptjm-23	418	7	inhaled	inhaled	ADJ
bptjm-23	418	8	therapy	therapy	NOUN
bptjm-23	418	9	and	and	CCONJ
bptjm-23	418	10	its	its	PRON
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bptjm-23	418	12	on	on	ADP
bptjm-23	418	13	chronic	chronic	ADJ
bptjm-23	418	14	obstructive	obstructive	ADJ
bptjm-23	418	15	pulmonary	pulmonary	ADJ
bptjm-23	418	16	disease	disease	NOUN
bptjm-23	418	17	(	(	PUNCT
bptjm-23	418	18	copd	copd	PROPN
bptjm-23	418	19	)	)	PUNCT
bptjm-23	418	20	.	.	PUNCT
bptjm-23	419	1	bmc	bmc	NOUN
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bptjm-23	419	4	.	.	PUNCT
bptjm-23	420	1	2018;18(163	2018;18(163	NUM
bptjm-23	420	2	)	)	PUNCT
bptjm-23	420	3	.	.	PUNCT
bptjm-23	421	1	https://doi.org/10.1186/s12890-018-0724-3	https://doi.org/10.1186/s12890-018-0724-3	NUM
bptjm-23	421	2	47	47	NUM
bptjm-23	421	3	.	.	PUNCT
bptjm-23	422	1	ensign	ensign	PROPN
bptjm-23	422	2	lm	lm	PROPN
bptjm-23	422	3	,	,	PUNCT
bptjm-23	422	4	schneider	schneider	PROPN
bptjm-23	422	5	c	c	PROPN
bptjm-23	422	6	,	,	PUNCT
bptjm-23	422	7	suk	suk	PROPN
bptjm-23	422	8	js	js	PROPN
bptjm-23	422	9	,	,	PUNCT
bptjm-23	422	10	cone	cone	NOUN
bptjm-23	422	11	r	r	PROPN
bptjm-23	422	12	,	,	PUNCT
bptjm-23	422	13	hanes	hanes	PROPN
bptjm-23	422	14	j.	j.	PROPN
bptjm-23	422	15	mucus	mucus	PROPN
bptjm-23	422	16	penetrating	penetrate	VERB
bptjm-23	422	17	nanoparticles	nanoparticle	NOUN
bptjm-23	422	18	:	:	PUNCT
bptjm-23	422	19	biophysical	biophysical	ADJ
bptjm-23	422	20	tool	tool	NOUN
bptjm-23	422	21	and	and	CCONJ
bptjm-23	422	22	method	method	NOUN
bptjm-23	422	23	of	of	ADP
bptjm-23	422	24	drug	drug	NOUN
bptjm-23	422	25	and	and	CCONJ
bptjm-23	422	26	gene	gene	NOUN
bptjm-23	422	27	delivery	delivery	NOUN
bptjm-23	422	28	.	.	PUNCT
bptjm-23	423	1	adv	adv	PROPN
bptjm-23	423	2	mater	mater	NOUN
bptjm-23	423	3	.	.	PUNCT
bptjm-23	424	1	2012;24(28):3887	2012;24(28):3887	NUM
bptjm-23	424	2	-	-	SYM
bptjm-23	424	3	3894	3894	NUM
bptjm-23	424	4	.	.	PUNCT
bptjm-23	425	1	doi:10.1002	doi:10.1002	NOUN
bptjm-23	425	2	/	/	SYM
bptjm-23	425	3	adma.201201800	adma.201201800	PROPN
bptjm-23	425	4	48	48	NUM
bptjm-23	425	5	.	.	PUNCT
bptjm-23	426	1	broekman	broekman	PROPN
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bptjm-23	426	3	,	,	PUNCT
bptjm-23	426	4	khedoe	khedoe	NOUN
bptjm-23	426	5	ppsj	ppsj	NOUN
bptjm-23	426	6	,	,	PUNCT
bptjm-23	426	7	schepers	schepers	PROPN
bptjm-23	426	8	k	k	PROPN
bptjm-23	426	9	,	,	PUNCT
bptjm-23	426	10	roelofs	roelofs	NOUN
bptjm-23	426	11	h	h	NOUN
bptjm-23	426	12	,	,	PUNCT
bptjm-23	426	13	stolk	stolk	PROPN
bptjm-23	426	14	j	j	PROPN
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bptjm-23	426	16	hiemstra	hiemstra	PROPN
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bptjm-23	426	18	.	.	PROPN
bptjm-23	426	19	mesenchymal	mesenchymal	ADJ
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bptjm-23	426	21	cells	cell	NOUN
bptjm-23	426	22	:	:	PUNCT
bptjm-23	426	23	a	a	DET
bptjm-23	426	24	novel	novel	NOUN
bptjm-23	426	25	therapy	therapy	NOUN
bptjm-23	426	26	for	for	ADP
bptjm-23	426	27	the	the	DET
bptjm-23	426	28	treatment	treatment	NOUN
bptjm-23	426	29	of	of	ADP
bptjm-23	426	30	chronic	chronic	ADJ
bptjm-23	426	31	obstructive	obstructive	ADJ
bptjm-23	426	32	pulmonary	pulmonary	ADJ
bptjm-23	426	33	disease	disease	NOUN
bptjm-23	426	34	?	?	PUNCT
bptjm-23	426	35	.	.	PUNCT
bptjm-23	427	1	thorax	thorax	NOUN
bptjm-23	427	2	.	.	PUNCT
bptjm-23	428	1	2018;73(6):565	2018;73(6):565	NUM
bptjm-23	428	2	-	-	SYM
bptjm-23	428	3	574	574	NUM
bptjm-23	428	4	.	.	PUNCT
bptjm-23	429	1	doi:10.1136	doi:10.1136	NOUN
bptjm-23	429	2	/	/	SYM
bptjm-23	429	3	thoraxjnl-2017	thoraxjnl-2017	NOUN
bptjm-23	429	4	-	-	PUNCT
bptjm-23	429	5	210672	210672	NUM
bptjm-23	429	6	49	49	NUM
bptjm-23	429	7	.	.	PUNCT
bptjm-23	430	1	broekman	broekman	PROPN
bptjm-23	430	2	w	w	PROPN
bptjm-23	430	3	,	,	PUNCT
bptjm-23	430	4	khedoe	khedoe	NOUN
bptjm-23	430	5	ppsj	ppsj	NOUN
bptjm-23	430	6	,	,	PUNCT
bptjm-23	430	7	schepers	schepers	PROPN
bptjm-23	430	8	k	k	PROPN
bptjm-23	430	9	,	,	PUNCT
bptjm-23	430	10	et	et	PROPN
bptjm-23	430	11	al	al	PROPN
bptjm-23	430	12	.	.	PUNCT
bptjm-23	431	1	mesenchymal	mesenchymal	ADJ
bptjm-23	431	2	stromal	stromal	ADJ
bptjm-23	431	3	cells	cell	NOUN
bptjm-23	431	4	:	:	PUNCT
bptjm-23	431	5	a	a	DET
bptjm-23	431	6	novel	novel	NOUN
bptjm-23	431	7	therapy	therapy	NOUN
bptjm-23	431	8	for	for	ADP
bptjm-23	431	9	the	the	DET
bptjm-23	431	10	treatment	treatment	NOUN
bptjm-23	431	11	of	of	ADP
bptjm-23	431	12	chronic	chronic	ADJ
bptjm-23	431	13	obstructive	obstructive	ADJ
bptjm-23	431	14	pulmonary	pulmonary	ADJ
bptjm-23	431	15	disease?thorax	disease?thorax	PROPN
bptjm-23	431	16	.	.	PUNCT
bptjm-23	432	1	2018;73:565	2018;73:565	NUM
bptjm-23	432	2	-	-	PUNCT
bptjm-23	432	3	574	574	NUM
bptjm-23	432	4	.	.	PUNCT
bptjm-23	433	1	https://doi.org/10.1136/thoraxjnl-2017-210672	https://doi.org/10.1136/thoraxjnl-2017-210672	PROPN
bptjm-23	433	2	50	50	NUM
bptjm-23	433	3	.	.	PUNCT
bptjm-23	433	4	sitkauskiene	sitkauskiene	PROPN
bptjm-23	433	5	b	b	PROPN
bptjm-23	433	6	,	,	PUNCT
bptjm-23	433	7	et	et	PROPN
bptjm-23	433	8	al	al	PROPN
bptjm-23	433	9	.	.	PUNCT
bptjm-23	434	1	screening	screen	VERB
bptjm-23	434	2	for	for	ADP
bptjm-23	434	3	alpha1	alpha1	NOUN
bptjm-23	434	4	-	-	PUNCT
bptjm-23	434	5	antitrypsin	antitrypsin	NOUN
bptjm-23	434	6	de	de	NOUN
bptjm-23	434	7	�	�	NOUN
bptjm-23	434	8	ciency	ciency	NOUN
bptjm-23	434	9	in	in	ADP
bptjm-23	434	10	lithuanian	lithuanian	ADJ
bptjm-23	434	11	patients	patient	NOUN
bptjm-23	434	12	with	with	ADP
bptjm-23	434	13	copd	copd	PROPN
bptjm-23	434	14	.	.	PUNCT
bptjm-23	435	1	resp	resp	PROPN
bptjm-23	435	2	med	med	PROPN
bptjm-23	435	3	.	.	PUNCT
bptjm-23	436	1	2008;102(11):1654–1658	2008;102(11):1654–1658	NUM
bptjm-23	436	2	.	.	PUNCT
bptjm-23	437	1	https://doi.org/10.1016/j.rmed.2008.07.003	https://doi.org/10.1016/j.rmed.2008.07.003	PROPN
bptjm-23	437	2	.	.	PROPN
bptjm-23	437	3	51	51	NUM
bptjm-23	437	4	.	.	PUNCT
bptjm-23	438	1	russo	russo	PROPN
bptjm-23	438	2	r	r	PROPN
bptjm-23	438	3	,	,	PUNCT
bptjm-23	438	4	zillmer	zillmer	PROPN
bptjm-23	438	5	lr	lr	PROPN
bptjm-23	438	6	,	,	PUNCT
bptjm-23	438	7	nascimento	nascimento	PROPN
bptjm-23	438	8	oa	oa	PROPN
bptjm-23	438	9	,	,	PUNCT
bptjm-23	438	10	et	et	PROPN
bptjm-23	438	11	al	al	PROPN
bptjm-23	438	12	.	.	PUNCT
bptjm-23	439	1	prevalence	prevalence	NOUN
bptjm-23	439	2	of	of	ADP
bptjm-23	439	3	alpha-1	alpha-1	NUM
bptjm-23	439	4	antitrypsin	antitrypsin	PROPN
bptjm-23	439	5	de	de	NOUN
bptjm-23	439	6	�	�	NOUN
bptjm-23	439	7	ciency	ciency	NOUN
bptjm-23	439	8	and	and	CCONJ
bptjm-23	439	9	allele	allele	NOUN
bptjm-23	439	10	frequency	frequency	NOUN
bptjm-23	439	11	in	in	ADP
bptjm-23	439	12	patients	patient	NOUN
bptjm-23	439	13	with	with	ADP
bptjm-23	439	14	copd	copd	PROPN
bptjm-23	439	15	in	in	ADP
bptjm-23	439	16	brazil	brazil	PROPN
bptjm-23	439	17	.	.	PUNCT
bptjm-23	440	1	j	j	PROPN
bptjm-23	440	2	bras	bras	PROPN
bptjm-23	440	3	pneumol	pneumol	NOUN
bptjm-23	440	4	.	.	PUNCT
bptjm-23	441	1	2016;42(5):311	2016;42(5):311	NUM
bptjm-23	441	2	-	-	PUNCT
bptjm-23	441	3	316	316	NUM
bptjm-23	441	4	.	.	PUNCT
bptjm-23	441	5	doi:10.1590	doi:10.1590	ADJ
bptjm-23	441	6	/	/	SYM
bptjm-23	441	7	s1806	s1806	NOUN
bptjm-23	441	8	-	-	NOUN
bptjm-23	441	9	37562015000000180	37562015000000180	NUM
bptjm-23	441	10	52	52	NUM
bptjm-23	441	11	.	.	PUNCT
bptjm-23	442	1	kim	kim	PROPN
bptjm-23	442	2	wj	wj	PROPN
bptjm-23	442	3	,	,	PUNCT
bptjm-23	442	4	et	et	PROPN
bptjm-23	442	5	al	al	PROPN
bptjm-23	442	6	.	.	PROPN
bptjm-23	442	7	altered	alter	VERB
bptjm-23	442	8	mirna	mirna	PROPN
bptjm-23	442	9	expression	expression	NOUN
bptjm-23	442	10	in	in	ADP
bptjm-23	442	11	lung	lung	NOUN
bptjm-23	442	12	tissues	tissue	NOUN
bptjm-23	442	13	of	of	ADP
bptjm-23	442	14	patients	patient	NOUN
bptjm-23	442	15	with	with	ADP
bptjm-23	442	16	chronic	chronic	ADJ
bptjm-23	442	17	obstructive	obstructive	ADJ
bptjm-23	442	18	pulmonary	pulmonary	ADJ
bptjm-23	442	19	disease	disease	NOUN
bptjm-23	442	20	.	.	PUNCT
bptjm-23	443	1	mol	mol	PROPN
bptjm-23	443	2	&	&	CCONJ
bptjm-23	443	3	cell	cell	PROPN
bptjm-23	443	4	tox	tox	PROPN
bptjm-23	443	5	.	.	PUNCT
bptjm-23	444	1	2017;13(2):207–212	2017;13(2):207–212	NUM
bptjm-23	444	2	.	.	PUNCT
bptjm-23	444	3	https://doi.org/10.1007/s13273-017-0022-9	https://doi.org/10.1007/s13273-017-0022-9	VERB
bptjm-23	444	4	53	53	NUM
bptjm-23	444	5	.	.	PUNCT
bptjm-23	445	1	zhu	zhu	PROPN
bptjm-23	445	2	m	m	PROPN
bptjm-23	445	3	,	,	PUNCT
bptjm-23	445	4	ye	ye	PRON
bptjm-23	445	5	m	m	PROPN
bptjm-23	445	6	,	,	PUNCT
bptjm-23	445	7	wang	wang	PROPN
bptjm-23	445	8	j	j	PROPN
bptjm-23	445	9	,	,	PUNCT
bptjm-23	445	10	ye	ye	PROPN
bptjm-23	445	11	l	l	NOUN
bptjm-23	445	12	,	,	PUNCT
bptjm-23	445	13	jin	jin	PROPN
bptjm-23	445	14	m.	m.	NOUN
bptjm-23	445	15	construction	construction	NOUN
bptjm-23	445	16	of	of	ADP
bptjm-23	445	17	potential	potential	ADJ
bptjm-23	445	18	mirna	mirna	PROPN
bptjm-23	445	19	–	–	PUNCT
bptjm-23	445	20	mrna	mrna	PROPN
bptjm-23	445	21	regulatory	regulatory	ADJ
bptjm-23	445	22	network	network	NOUN
bptjm-23	445	23	in	in	ADP
bptjm-23	445	24	copd	copd	NOUN
bptjm-23	445	25	plasma	plasma	NOUN
bptjm-23	445	26	by	by	ADP
bptjm-23	445	27	bioinformatics	bioinformatics	NOUN
bptjm-23	445	28	analysis	analysis	NOUN
bptjm-23	445	29	.	.	PUNCT
bptjm-23	446	1	int	int	NOUN
bptjm-23	446	2	j	j	PROPN
bptjm-23	446	3	chron	chron	NOUN
bptjm-23	446	4	obstruct	obstruct	VERB
bptjm-23	446	5	pulmon	pulmon	PROPN
bptjm-23	446	6	dis	dis	PROPN
bptjm-23	446	7	.	.	PUNCT
bptjm-23	447	1	2020;15:2135	2020;15:2135	NUM
bptjm-23	447	2	-	-	SYM
bptjm-23	447	3	2145	2145	NUM
bptjm-23	447	4	.	.	PUNCT
bptjm-23	448	1	https://doi.org/10.2147/copd.s255262	https://doi.org/10.2147/copd.s255262	PROPN
bptjm-23	448	2	54	54	NUM
bptjm-23	448	3	.	.	PUNCT
bptjm-23	449	1	wang	wang	PROPN
bptjm-23	449	2	c	c	PROPN
bptjm-23	449	3	,	,	PUNCT
bptjm-23	449	4	et	et	PROPN
bptjm-23	449	5	al	al	PROPN
bptjm-23	449	6	.	.	PROPN
bptjm-23	449	7	dysregulated	dysregulated	ADJ
bptjm-23	449	8	circulating	circulate	VERB
bptjm-23	449	9	microrna‐126	microrna‐126	NOUN
bptjm-23	449	10	in	in	ADP
bptjm-23	449	11	chronic	chronic	ADJ
bptjm-23	449	12	obstructive	obstructive	ADJ
bptjm-23	449	13	pulmonary	pulmonary	ADJ
bptjm-23	449	14	disease	disease	NOUN
bptjm-23	449	15	:	:	PUNCT
bptjm-23	449	16	linkage	linkage	NOUN
bptjm-23	449	17	with	with	ADP
bptjm-23	449	18	acute	acute	ADJ
bptjm-23	449	19	exacerbation	exacerbation	NOUN
bptjm-23	449	20	risk	risk	NOUN
bptjm-23	449	21	,	,	PUNCT
bptjm-23	449	22	severity	severity	NOUN
bptjm-23	449	23	degree	degree	NOUN
bptjm-23	449	24	,	,	PUNCT
bptjm-23	449	25	and	and	CCONJ
bptjm-23	449	26	in	in	ADP
bptjm-23	449	27	�	�	NOUN
bptjm-23	449	28	ammatory	ammatory	NOUN
bptjm-23	449	29	cytokines	cytokine	NOUN
bptjm-23	449	30	.	.	PUNCT
bptjm-23	450	1	j	j	PROPN
bptjm-23	450	2	clin	clin	PROPN
bptjm-23	450	3	lab	lab	PROPN
bptjm-23	450	4	ana	ana	PROPN
bptjm-23	450	5	.	.	PUNCT
bptjm-23	451	1	2002;36(3	2002;36(3	NUM
bptjm-23	451	2	)	)	PUNCT
bptjm-23	451	3	.	.	PUNCT
bptjm-23	452	1	https://doi.org/10.1002/jcla.24204	https://doi.org/10.1002/jcla.24204	PROPN
bptjm-23	452	2	55	55	NUM
bptjm-23	452	3	.	.	PUNCT
bptjm-23	453	1	bobba	bobba	PROPN
bptjm-23	453	2	cm	cm	PROPN
bptjm-23	453	3	,	,	PUNCT
bptjm-23	453	4	fei	fei	PROPN
bptjm-23	453	5	q	q	PROPN
bptjm-23	453	6	,	,	PUNCT
bptjm-23	453	7	shukla	shukla	NOUN
bptjm-23	453	8	v	v	NOUN
bptjm-23	453	9	,	,	PUNCT
bptjm-23	453	10	et	et	PROPN
bptjm-23	453	11	al	al	PROPN
bptjm-23	453	12	.	.	PROPN
bptjm-23	453	13	nanoparticle	nanoparticle	PROPN
bptjm-23	453	14	delivery	delivery	NOUN
bptjm-23	453	15	of	of	ADP
bptjm-23	453	16	microrna-146a	microrna-146a	PROPN
bptjm-23	453	17	regulates	regulate	VERB
bptjm-23	453	18	mechanotransduction	mechanotransduction	NOUN
bptjm-23	453	19	in	in	ADP
bptjm-23	453	20	lung	lung	NOUN
bptjm-23	453	21	macrophages	macrophage	NOUN
bptjm-23	453	22	and	and	CCONJ
bptjm-23	453	23	mitigates	mitigate	VERB
bptjm-23	453	24	injury	injury	NOUN
bptjm-23	453	25	during	during	ADP
bptjm-23	453	26	mechanical	mechanical	ADJ
bptjm-23	453	27	ventilation	ventilation	NOUN
bptjm-23	453	28	.	.	PUNCT
bptjm-23	454	1	nat	nat	PROPN
bptjm-23	454	2	commun	commun	PROPN
bptjm-23	454	3	.	.	PUNCT
bptjm-23	455	1	2021;12(289	2021;12(289	NUM
bptjm-23	455	2	)	)	PUNCT
bptjm-23	455	3	.	.	PUNCT
bptjm-23	456	1	https://doi.org/10.1038/s41467-020-20449-w	https://doi.org/10.1038/s41467-020-20449-w	PROPN
bptjm-23	456	2	berkeley	berkeley	PROPN
bptjm-23	456	3	pharma	pharma	PROPN
bptjm-23	456	4	tech	tech	NOUN
bptjm-23	456	5	journal	journal	NOUN
bptjm-23	456	6	of	of	ADP
bptjm-23	456	7	medicine	medicine	NOUN
bptjm-23	456	8	|	|	ADV
bptjm-23	456	9	80	80	NUM
bptjm-23	456	10	front_page_calendine	front_page_calendine	ADJ
bptjm-23	456	11	calendine	calendine	NOUN
bptjm-23	456	12	body	body	NOUN
bptjm-23	456	13	template.docx-2	template.docx-2	PROPN
bptjm-23	456	14	calendine	calendine	NOUN
bptjm-23	456	15	reference	reference	NOUN
bptjm-23	456	16	template	template	NOUN