id	sid	tid	token	lemma	pos
bptjm-28	1	1	berkeley	berkeley	PROPN
bptjm-28	1	2	pharma	pharma	PROPN
bptjm-28	1	3	tech	tech	NOUN
bptjm-28	1	4	journal	journal	NOUN
bptjm-28	1	5	of	of	ADP
bptjm-28	1	6	medicine	medicine	NOUN
bptjm-28	1	7	correspondence	correspondence	NOUN
bptjm-28	1	8	:	:	PUNCT
bptjm-28	1	9	�	�	PROPN
bptjm-28	1	10	venkatarepaka@gmail.com	venkatarepaka@gmail.com	X
bptjm-28	1	11	keywords	keyword	NOUN
bptjm-28	1	12	:	:	PUNCT
bptjm-28	1	13	thrombin	thrombin	NOUN
bptjm-28	1	14	hemophilia	hemophilia	NOUN
bptjm-28	1	15	factors	factor	NOUN
bptjm-28	1	16	viii	viii	VERB
bptjm-28	1	17	and	and	CCONJ
bptjm-28	1	18	fix	fix	NOUN
bptjm-28	1	19	hepatocytes	hepatocyte	NOUN
bptjm-28	1	20	aav	aav	NOUN
bptjm-28	1	21	vector	vector	NOUN
bptjm-28	1	22	inhibitors	inhibitor	NOUN
bptjm-28	1	23	viral	viral	ADJ
bptjm-28	1	24	vectors	vector	NOUN
bptjm-28	1	25	submitted	submit	VERB
bptjm-28	1	26	may	may	PROPN
bptjm-28	1	27	3	3	NUM
bptjm-28	1	28	,	,	PUNCT
bptjm-28	1	29	2022	2022	NUM
bptjm-28	1	30	�	�	PROPN
bptjm-28	1	31	accepted	accept	VERB
bptjm-28	1	32	�	�	PROPN
bptjm-28	1	33	june	june	PROPN
bptjm-28	1	34	8	8	NUM
bptjm-28	1	35	,	,	PUNCT
bptjm-28	1	36	2022	2022	NUM
bptjm-28	1	37	published	publish	VERB
bptjm-28	1	38	july	july	PROPN
bptjm-28	1	39	19	19	NUM
bptjm-28	1	40	,	,	PUNCT
bptjm-28	1	41	2022	2022	NUM
bptjm-28	1	42	full	full	ADJ
bptjm-28	1	43	open	open	ADJ
bptjm-28	1	44	access	access	NOUN
bptjm-28	1	45	creative	creative	ADJ
bptjm-28	1	46	commons	common	NOUN
bptjm-28	1	47	attribution	attribution	NOUN
bptjm-28	1	48	license	license	NOUN
bptjm-28	1	49	4.0	4.0	NUM
bptjm-28	1	50	abstract	abstract	ADJ
bptjm-28	1	51	hemophilia	hemophilia	NOUN
bptjm-28	1	52	is	be	AUX
bptjm-28	1	53	an	an	DET
bptjm-28	1	54	x	x	ADV
bptjm-28	1	55	-	-	VERB
bptjm-28	1	56	linked	link	VERB
bptjm-28	1	57	recessive	recessive	ADJ
bptjm-28	1	58	genetic	genetic	ADJ
bptjm-28	1	59	disorder	disorder	NOUN
bptjm-28	1	60	in	in	ADP
bptjm-28	1	61	which	which	PRON
bptjm-28	1	62	the	the	DET
bptjm-28	1	63	body	body	NOUN
bptjm-28	1	64	has	have	VERB
bptjm-28	1	65	an	an	DET
bptjm-28	1	66	inability	inability	NOUN
bptjm-28	1	67	to	to	ADP
bptjm-28	1	68	clot	clot	NOUN
bptjm-28	1	69	,	,	PUNCT
bptjm-28	1	70	leading	lead	VERB
bptjm-28	1	71	to	to	ADP
bptjm-28	1	72	an	an	DET
bptjm-28	1	73	increased	increase	VERB
bptjm-28	1	74	risk	risk	NOUN
bptjm-28	1	75	of	of	ADP
bptjm-28	1	76	mortality	mortality	NOUN
bptjm-28	1	77	for	for	ADP
bptjm-28	1	78	individuals	individual	NOUN
bptjm-28	1	79	if	if	SCONJ
bptjm-28	1	80	a	a	DET
bptjm-28	1	81	bleeding	bleeding	NOUN
bptjm-28	1	82	episode	episode	NOUN
bptjm-28	1	83	were	be	AUX
bptjm-28	1	84	to	to	PART
bptjm-28	1	85	occur	occur	VERB
bptjm-28	1	86	.	.	PUNCT
bptjm-28	2	1	traditional	traditional	ADJ
bptjm-28	2	2	hemophilia	hemophilia	NOUN
bptjm-28	2	3	treatments	treatment	NOUN
bptjm-28	2	4	,	,	PUNCT
bptjm-28	2	5	such	such	ADJ
bptjm-28	2	6	as	as	ADP
bptjm-28	2	7	prophylactic	prophylactic	ADJ
bptjm-28	2	8	factor	factor	NOUN
bptjm-28	2	9	replacement	replacement	NOUN
bptjm-28	2	10	therapy	therapy	NOUN
bptjm-28	2	11	of	of	ADP
bptjm-28	2	12	recombinant	recombinant	ADJ
bptjm-28	2	13	factor	factor	NOUN
bptjm-28	2	14	viii	viii	NOUN
bptjm-28	2	15	and	and	CCONJ
bptjm-28	2	16	ix	ix	ADV
bptjm-28	2	17	,	,	PUNCT
bptjm-28	2	18	have	have	AUX
bptjm-28	2	19	been	be	AUX
bptjm-28	2	20	proven	prove	VERB
bptjm-28	2	21	to	to	PART
bptjm-28	2	22	be	be	AUX
bptjm-28	2	23	costly	costly	ADJ
bptjm-28	2	24	and	and	CCONJ
bptjm-28	2	25	do	do	AUX
bptjm-28	2	26	not	not	PART
bptjm-28	2	27	provide	provide	VERB
bptjm-28	2	28	long	long	ADV
bptjm-28	2	29	-	-	PUNCT
bptjm-28	2	30	lasting	last	VERB
bptjm-28	2	31	protection	protection	NOUN
bptjm-28	2	32	during	during	ADP
bptjm-28	2	33	bleeding	bleed	VERB
bptjm-28	2	34	episodes	episode	NOUN
bptjm-28	2	35	.	.	PUNCT
bptjm-28	3	1	in	in	ADP
bptjm-28	3	2	recent	recent	ADJ
bptjm-28	3	3	years	year	NOUN
bptjm-28	3	4	,	,	PUNCT
bptjm-28	3	5	the	the	DET
bptjm-28	3	6	use	use	NOUN
bptjm-28	3	7	of	of	ADP
bptjm-28	3	8	adeno	adeno	NOUN
bptjm-28	3	9	-	-	PUNCT
bptjm-28	3	10	associated	associate	VERB
bptjm-28	3	11	viral	viral	ADJ
bptjm-28	3	12	vectors	vector	NOUN
bptjm-28	3	13	(	(	PUNCT
bptjm-28	3	14	aav	aav	NOUN
bptjm-28	3	15	)	)	PUNCT
bptjm-28	3	16	gene	gene	NOUN
bptjm-28	3	17	therapy	therapy	NOUN
bptjm-28	3	18	has	have	AUX
bptjm-28	3	19	been	be	AUX
bptjm-28	3	20	explored	explore	VERB
bptjm-28	3	21	as	as	ADP
bptjm-28	3	22	a	a	DET
bptjm-28	3	23	potential	potential	ADJ
bptjm-28	3	24	alternative	alternative	NOUN
bptjm-28	3	25	due	due	ADJ
bptjm-28	3	26	to	to	ADP
bptjm-28	3	27	efficient	efficient	ADJ
bptjm-28	3	28	gene	gene	NOUN
bptjm-28	3	29	delivery	delivery	NOUN
bptjm-28	3	30	and	and	CCONJ
bptjm-28	3	31	tissue	tissue	NOUN
bptjm-28	3	32	tropism	tropism	NOUN
bptjm-28	3	33	,	,	PUNCT
bptjm-28	3	34	overall	overall	ADJ
bptjm-28	3	35	safety	safety	NOUN
bptjm-28	3	36	and	and	CCONJ
bptjm-28	3	37	efficacy	efficacy	NOUN
bptjm-28	3	38	,	,	PUNCT
bptjm-28	3	39	and	and	CCONJ
bptjm-28	3	40	longer	long	ADV
bptjm-28	3	41	-	-	PUNCT
bptjm-28	3	42	lasting	last	VERB
bptjm-28	3	43	effects	effect	NOUN
bptjm-28	3	44	.	.	PUNCT
bptjm-28	4	1	however	however	ADV
bptjm-28	4	2	,	,	PUNCT
bptjm-28	4	3	concerns	concern	NOUN
bptjm-28	4	4	over	over	ADP
bptjm-28	4	5	inhibitor	inhibitor	NOUN
bptjm-28	4	6	development	development	NOUN
bptjm-28	4	7	persist	persist	VERB
bptjm-28	4	8	due	due	ADP
bptjm-28	4	9	to	to	ADP
bptjm-28	4	10	the	the	DET
bptjm-28	4	11	treatment	treatment	NOUN
bptjm-28	4	12	complications	complication	NOUN
bptjm-28	4	13	.	.	PUNCT
bptjm-28	5	1	this	this	DET
bptjm-28	5	2	review	review	NOUN
bptjm-28	5	3	article	article	NOUN
bptjm-28	5	4	seeks	seek	VERB
bptjm-28	5	5	to	to	PART
bptjm-28	5	6	provide	provide	VERB
bptjm-28	5	7	an	an	DET
bptjm-28	5	8	overview	overview	NOUN
bptjm-28	5	9	of	of	ADP
bptjm-28	5	10	the	the	DET
bptjm-28	5	11	current	current	ADJ
bptjm-28	5	12	state	state	NOUN
bptjm-28	5	13	of	of	ADP
bptjm-28	5	14	aav	aav	PROPN
bptjm-28	5	15	-	-	PUNCT
bptjm-28	5	16	based	base	VERB
bptjm-28	5	17	gene	gene	NOUN
bptjm-28	5	18	therapy	therapy	NOUN
bptjm-28	5	19	as	as	ADP
bptjm-28	5	20	a	a	DET
bptjm-28	5	21	treatment	treatment	NOUN
bptjm-28	5	22	for	for	ADP
bptjm-28	5	23	hemophilia	hemophilia	NOUN
bptjm-28	5	24	.	.	PUNCT
bptjm-28	6	1	gene	gene	NOUN
bptjm-28	6	2	therapy	therapy	NOUN
bptjm-28	6	3	for	for	ADP
bptjm-28	6	4	hemophilia	hemophilia	PROPN
bptjm-28	6	5	�	�	PROPN
bptjm-28	6	6	ïw	ïw	PROPN
bptjm-28	6	7	�	�	PROPN
bptjm-28	6	8	venkata	venkata	PROPN
bptjm-28	6	9	repakau	repakau	PROPN
bptjm-28	6	10	�	�	PROPN
bptjm-28	6	11	daniel	daniel	PROPN
bptjm-28	6	12	lomboy	lomboy	PROPN
bptjm-28	6	13	,	,	PUNCT
bptjm-28	6	14	priscilla	priscilla	PROPN
bptjm-28	6	15	castro	castro	PROPN
bptjm-28	6	16	introduction	introduction	PROPN
bptjm-28	6	17	i.	i.	PROPN
bptjm-28	6	18	background	background	PROPN
bptjm-28	6	19	information	information	PROPN
bptjm-28	6	20	hemophilia	hemophilia	PROPN
bptjm-28	6	21	is	be	AUX
bptjm-28	6	22	a	a	DET
bptjm-28	6	23	bleeding	bleed	VERB
bptjm-28	6	24	disorder	disorder	NOUN
bptjm-28	6	25	associated	associate	VERB
bptjm-28	6	26	with	with	ADP
bptjm-28	6	27	di	di	PROPN
bptjm-28	6	28	�	�	PROPN
bptjm-28	6	29	culties	cultie	NOUN
bptjm-28	6	30	in	in	ADP
bptjm-28	6	31	blood	blood	NOUN
bptjm-28	6	32	clotting	clotting	NOUN
bptjm-28	6	33	.	.	PUNCT
bptjm-28	7	1	these	these	DET
bptjm-28	7	2	complications	complication	NOUN
bptjm-28	7	3	are	be	AUX
bptjm-28	7	4	caused	cause	VERB
bptjm-28	7	5	by	by	ADP
bptjm-28	7	6	the	the	DET
bptjm-28	7	7	low	low	ADJ
bptjm-28	7	8	levels	level	NOUN
bptjm-28	7	9	of	of	ADP
bptjm-28	7	10	factor	factor	NOUN
bptjm-28	7	11	viii	viii	NOUN
bptjm-28	7	12	,	,	PUNCT
bptjm-28	7	13	associated	associate	VERB
bptjm-28	7	14	with	with	ADP
bptjm-28	7	15	hemophilia	hemophilia	PROPN
bptjm-28	7	16	a	a	PRON
bptjm-28	7	17	,	,	PUNCT
bptjm-28	7	18	or	or	CCONJ
bptjm-28	7	19	factor	factor	NOUN
bptjm-28	7	20	ix	ix	ADV
bptjm-28	7	21	,	,	PUNCT
bptjm-28	7	22	associated	associate	VERB
bptjm-28	7	23	with	with	ADP
bptjm-28	7	24	hemophilia	hemophilia	PROPN
bptjm-28	7	25	b.	b.	PROPN
bptjm-28	8	1	the	the	DET
bptjm-28	8	2	amount	amount	NOUN
bptjm-28	8	3	of	of	ADP
bptjm-28	8	4	clotting	clotting	NOUN
bptjm-28	8	5	factor	factor	NOUN
bptjm-28	8	6	de	de	NOUN
bptjm-28	8	7	�	�	NOUN
bptjm-28	8	8	ciency	ciency	NOUN
bptjm-28	8	9	determines	determine	VERB
bptjm-28	8	10	the	the	DET
bptjm-28	8	11	severity	severity	NOUN
bptjm-28	8	12	of	of	ADP
bptjm-28	8	13	hemophilia	hemophilia	NOUN
bptjm-28	8	14	for	for	ADP
bptjm-28	8	15	each	each	DET
bptjm-28	8	16	patient1	patient1	NOUN
bptjm-28	8	17	-	-	SYM
bptjm-28	8	18	3	3	NUM
bptjm-28	8	19	.	.	PUNCT
bptjm-28	8	20	hemophilia	hemophilia	PROPN
bptjm-28	8	21	a	a	DET
bptjm-28	8	22	�	�	NOUN
bptjm-28	8	23	ects	ect	VERB
bptjm-28	8	24	over	over	ADP
bptjm-28	8	25	30,000	30,000	NUM
bptjm-28	8	26	individuals	individual	NOUN
bptjm-28	8	27	in	in	ADP
bptjm-28	8	28	the	the	DET
bptjm-28	8	29	united	united	PROPN
bptjm-28	8	30	states	states	PROPN
bptjm-28	8	31	.	.	PUNCT
bptjm-28	9	1	over	over	ADP
bptjm-28	9	2	half	half	NOUN
bptjm-28	9	3	(	(	PUNCT
bptjm-28	9	4	around	around	ADV
bptjm-28	9	5	60	60	NUM
bptjm-28	9	6	%	%	NOUN
bptjm-28	9	7	)	)	PUNCT
bptjm-28	9	8	of	of	ADP
bptjm-28	9	9	that	that	DET
bptjm-28	9	10	population	population	NOUN
bptjm-28	9	11	is	be	AUX
bptjm-28	9	12	diagnosed	diagnose	VERB
bptjm-28	9	13	with	with	ADP
bptjm-28	9	14	severe	severe	ADJ
bptjm-28	9	15	hemophilia	hemophilia	NOUN
bptjm-28	9	16	while	while	SCONJ
bptjm-28	9	17	fewer	few	ADJ
bptjm-28	9	18	su	su	PROPN
bptjm-28	9	19	�	�	PROPN
bptjm-28	9	20	er	er	NOUN
bptjm-28	9	21	from	from	ADP
bptjm-28	9	22	moderate	moderate	ADJ
bptjm-28	9	23	and	and	CCONJ
bptjm-28	9	24	mild	mild	ADJ
bptjm-28	9	25	hemophilia	hemophilia	NOUN
bptjm-28	9	26	.	.	PUNCT
bptjm-28	10	1	hemophilia	hemophilia	PROPN
bptjm-28	10	2	a	a	PRON
bptjm-28	10	3	is	be	AUX
bptjm-28	10	4	four	four	NUM
bptjm-28	10	5	times	time	NOUN
bptjm-28	10	6	more	more	ADV
bptjm-28	10	7	common	common	ADJ
bptjm-28	10	8	than	than	ADP
bptjm-28	10	9	hemophilia	hemophilia	NOUN
bptjm-28	10	10	b	b	NOUN
bptjm-28	10	11	and	and	CCONJ
bptjm-28	10	12	is	be	AUX
bptjm-28	10	13	one	one	NUM
bptjm-28	10	14	of	of	ADP
bptjm-28	10	15	the	the	DET
bptjm-28	10	16	most	most	ADV
bptjm-28	10	17	widely	widely	ADV
bptjm-28	10	18	distributed	distribute	VERB
bptjm-28	10	19	bleeding	bleeding	NOUN
bptjm-28	10	20	disorders	disorder	NOUN
bptjm-28	10	21	in	in	ADP
bptjm-28	10	22	the	the	DET
bptjm-28	10	23	population4	population4	NOUN
bptjm-28	10	24	.	.	PUNCT
bptjm-28	11	1	there	there	PRON
bptjm-28	11	2	are	be	VERB
bptjm-28	11	3	three	three	NUM
bptjm-28	11	4	classes	class	NOUN
bptjm-28	11	5	of	of	ADP
bptjm-28	11	6	hemophilia	hemophilia	NOUN
bptjm-28	11	7	:	:	PUNCT
bptjm-28	11	8	mild	mild	ADJ
bptjm-28	11	9	,	,	PUNCT
bptjm-28	11	10	moderate	moderate	ADJ
bptjm-28	11	11	,	,	PUNCT
bptjm-28	11	12	and	and	CCONJ
bptjm-28	11	13	severe	severe	ADJ
bptjm-28	11	14	.	.	PUNCT
bptjm-28	12	1	the	the	DET
bptjm-28	12	2	severity	severity	NOUN
bptjm-28	12	3	of	of	ADP
bptjm-28	12	4	hemophilia	hemophilia	NOUN
bptjm-28	12	5	is	be	AUX
bptjm-28	12	6	de	de	X
bptjm-28	12	7	�	�	NOUN
bptjm-28	12	8	ned	ne	VERB
bptjm-28	12	9	by	by	ADP
bptjm-28	12	10	the	the	DET
bptjm-28	12	11	percentage	percentage	NOUN
bptjm-28	12	12	of	of	ADP
bptjm-28	12	13	clotting	clotting	NOUN
bptjm-28	12	14	factor	factor	NOUN
bptjm-28	12	15	de	de	NOUN
bptjm-28	12	16	�	�	NOUN
bptjm-28	12	17	ciency	ciency	NOUN
bptjm-28	12	18	.	.	PUNCT
bptjm-28	13	1	a	a	DET
bptjm-28	13	2	healthy	healthy	ADJ
bptjm-28	13	3	range	range	NOUN
bptjm-28	13	4	of	of	ADP
bptjm-28	13	5	factor	factor	NOUN
bptjm-28	13	6	viii	viii	NOUN
bptjm-28	13	7	and	and	CCONJ
bptjm-28	13	8	ix	ix	ADJ
bptjm-28	13	9	is	be	AUX
bptjm-28	13	10	between	between	ADP
bptjm-28	13	11	50	50	NUM
bptjm-28	13	12	-	-	PUNCT
bptjm-28	13	13	150%factor	150%factor	NUM
bptjm-28	13	14	activity	activity	NOUN
bptjm-28	13	15	.	.	PUNCT
bptjm-28	14	1	individuals	individual	NOUN
bptjm-28	14	2	with	with	ADP
bptjm-28	14	3	mild	mild	ADJ
bptjm-28	14	4	hemophilia	hemophilia	NOUN
bptjm-28	14	5	have	have	VERB
bptjm-28	14	6	5	5	NUM
bptjm-28	14	7	-	-	SYM
bptjm-28	14	8	40	40	NUM
bptjm-28	14	9	%	%	NOUN
bptjm-28	14	10	factor	factor	NOUN
bptjm-28	14	11	activity	activity	NOUN
bptjm-28	14	12	where	where	SCONJ
bptjm-28	14	13	bleeding	bleeding	NOUN
bptjm-28	14	14	proceeds	proceed	NOUN
bptjm-28	14	15	injury	injury	NOUN
bptjm-28	14	16	,	,	PUNCT
bptjm-28	14	17	trauma	trauma	NOUN
bptjm-28	14	18	,	,	PUNCT
bptjm-28	14	19	or	or	CCONJ
bptjm-28	14	20	surgery	surgery	NOUN
bptjm-28	14	21	.	.	PUNCT
bptjm-28	15	1	moderate	moderate	ADJ
bptjm-28	15	2	hemophilia	hemophilia	PROPN
bptjm-28	15	3	has	have	VERB
bptjm-28	15	4	1	1	NUM
bptjm-28	15	5	-	-	SYM
bptjm-28	15	6	5	5	NUM
bptjm-28	15	7	%	%	NOUN
bptjm-28	15	8	factor	factor	NOUN
bptjm-28	15	9	activity	activity	NOUN
bptjm-28	15	10	where	where	SCONJ
bptjm-28	15	11	minor	minor	ADJ
bptjm-28	15	12	injuries	injury	NOUN
bptjm-28	15	13	or	or	CCONJ
bptjm-28	15	14	spontaneous	spontaneous	ADJ
bptjm-28	15	15	bleeding	bleeding	NOUN
bptjm-28	15	16	occurs	occur	NOUN
bptjm-28	15	17	.	.	PUNCT
bptjm-28	16	1	severe	severe	ADJ
bptjm-28	16	2	hemophilia	hemophilia	PROPN
bptjm-28	16	3	,	,	PUNCT
bptjm-28	16	4	the	the	DET
bptjm-28	16	5	most	most	ADV
bptjm-28	16	6	common	common	ADJ
bptjm-28	16	7	,	,	PUNCT
bptjm-28	16	8	is	be	AUX
bptjm-28	16	9	classi	classi	ADJ
bptjm-28	16	10	�	�	PROPN
bptjm-28	16	11	ed	ed	NOUN
bptjm-28	16	12	by	by	ADP
bptjm-28	16	13	<	<	NOUN
bptjm-28	16	14	1	1	NUM
bptjm-28	16	15	%	%	NOUN
bptjm-28	16	16	factor	factor	NOUN
bptjm-28	16	17	activity	activity	NOUN
bptjm-28	16	18	where	where	SCONJ
bptjm-28	16	19	frequent	frequent	ADJ
bptjm-28	16	20	exterior	exterior	ADJ
bptjm-28	16	21	or	or	CCONJ
bptjm-28	16	22	interior	interior	ADJ
bptjm-28	16	23	bleeds	bleed	NOUN
bptjm-28	16	24	may	may	AUX
bptjm-28	16	25	physically	physically	ADV
bptjm-28	16	26	disable	disable	VERB
bptjm-28	16	27	the	the	DET
bptjm-28	16	28	individual5	individual5	NOUN
bptjm-28	16	29	.	.	PUNCT
bptjm-28	17	1	current	current	ADJ
bptjm-28	17	2	non	non	ADJ
bptjm-28	17	3	-	-	ADJ
bptjm-28	17	4	gene	gene	ADJ
bptjm-28	17	5	therapy	therapy	NOUN
bptjm-28	17	6	includes	include	VERB
bptjm-28	17	7	methods	method	NOUN
bptjm-28	17	8	such	such	ADJ
bptjm-28	17	9	as	as	ADP
bptjm-28	17	10	direct	direct	ADJ
bptjm-28	17	11	infusion	infusion	NOUN
bptjm-28	17	12	of	of	ADP
bptjm-28	17	13	the	the	DET
bptjm-28	17	14	exogenous	exogenous	ADJ
bptjm-28	17	15	proteins6	proteins6	NOUN
bptjm-28	17	16	.	.	PUNCT
bptjm-28	18	1	these	these	DET
bptjm-28	18	2	speci	speci	PROPN
bptjm-28	18	3	�	�	PROPN
bptjm-28	18	4	c	c	NOUN
bptjm-28	18	5	methods	method	NOUN
bptjm-28	18	6	that	that	PRON
bptjm-28	18	7	are	be	AUX
bptjm-28	18	8	non	non	ADJ
bptjm-28	18	9	-	-	ADJ
bptjm-28	18	10	gene	gene	ADJ
bptjm-28	18	11	therapeutic	therapeutic	ADJ
bptjm-28	18	12	do	do	AUX
bptjm-28	18	13	not	not	PART
bptjm-28	18	14	provide	provide	VERB
bptjm-28	18	15	long	long	ADV
bptjm-28	18	16	-	-	PUNCT
bptjm-28	18	17	lasting	last	VERB
bptjm-28	18	18	e	e	NOUN
bptjm-28	18	19	�	�	NOUN
bptjm-28	18	20	ects	ect	NOUN
bptjm-28	18	21	due	due	ADJ
bptjm-28	18	22	to	to	ADP
bptjm-28	18	23	inhibitors	inhibitor	NOUN
bptjm-28	18	24	and	and	CCONJ
bptjm-28	18	25	antibodies	antibodie	VERB
bptjm-28	18	26	.	.	PUNCT
bptjm-28	19	1	replacement	replacement	NOUN
bptjm-28	19	2	therapy	therapy	NOUN
bptjm-28	19	3	is	be	AUX
bptjm-28	19	4	e	e	NOUN
bptjm-28	19	5	�	�	NOUN
bptjm-28	19	6	ective	ective	ADJ
bptjm-28	19	7	until	until	SCONJ
bptjm-28	19	8	an	an	DET
bptjm-28	19	9	alloantibody	alloantibody	NOUN
bptjm-28	19	10	is	be	AUX
bptjm-28	19	11	formed	form	VERB
bptjm-28	19	12	against	against	ADP
bptjm-28	19	13	the	the	DET
bptjm-28	19	14	exogenous	exogenous	ADJ
bptjm-28	19	15	clotting	clotting	NOUN
bptjm-28	19	16	factors7	factors7	NOUN
bptjm-28	19	17	.	.	PUNCT
bptjm-28	20	1	ii	ii	PROPN
bptjm-28	20	2	.	.	PUNCT
bptjm-28	21	1	emerging	emerge	VERB
bptjm-28	21	2	technologies	technology	NOUN
bptjm-28	21	3	when	when	SCONJ
bptjm-28	21	4	researching	research	VERB
bptjm-28	21	5	gene	gene	NOUN
bptjm-28	21	6	therapies	therapy	NOUN
bptjm-28	21	7	for	for	ADP
bptjm-28	21	8	hemophilia	hemophilia	NOUN
bptjm-28	21	9	,	,	PUNCT
bptjm-28	21	10	there	there	PRON
bptjm-28	21	11	were	be	VERB
bptjm-28	21	12	an	an	DET
bptjm-28	21	13	abundant	abundant	ADJ
bptjm-28	21	14	amount	amount	NOUN
bptjm-28	21	15	of	of	ADP
bptjm-28	21	16	other	other	ADJ
bptjm-28	21	17	gene	gene	NOUN
bptjm-28	21	18	therapies	therapy	NOUN
bptjm-28	21	19	shown	show	VERB
bptjm-28	21	20	to	to	PART
bptjm-28	21	21	be	be	AUX
bptjm-28	21	22	e	e	NOUN
bptjm-28	21	23	�	�	NOUN
bptjm-28	21	24	ective	ective	ADJ
bptjm-28	21	25	and	and	CCONJ
bptjm-28	21	26	helpful	helpful	ADJ
bptjm-28	21	27	.	.	PUNCT
bptjm-28	22	1	some	some	DET
bptjm-28	22	2	studies	study	NOUN
bptjm-28	22	3	used	use	VERB
bptjm-28	22	4	the	the	DET
bptjm-28	22	5	method	method	NOUN
bptjm-28	22	6	by	by	ADP
bptjm-28	22	7	adding	add	VERB
bptjm-28	22	8	more	more	ADJ
bptjm-28	22	9	precursor	precursor	NOUN
bptjm-28	22	10	proteins	protein	NOUN
bptjm-28	22	11	to	to	PART
bptjm-28	22	12	make	make	VERB
bptjm-28	22	13	the	the	DET
bptjm-28	22	14	factors	factor	NOUN
bptjm-28	22	15	fviii	fviii	VERB
bptjm-28	22	16	and	and	CCONJ
bptjm-28	22	17	fix	fix	NOUN
bptjm-28	22	18	,	,	PUNCT
bptjm-28	22	19	the	the	DET
bptjm-28	22	20	liver	liver	NOUN
bptjm-28	22	21	will	will	AUX
bptjm-28	22	22	be	be	AUX
bptjm-28	22	23	able	able	ADJ
bptjm-28	22	24	to	to	PART
bptjm-28	22	25	produce	produce	VERB
bptjm-28	22	26	thrombin	thrombin	NOUN
bptjm-28	22	27	and	and	CCONJ
bptjm-28	22	28	platelets	platelet	NOUN
bptjm-28	22	29	for	for	ADP
bptjm-28	22	30	hemophilic	hemophilic	ADJ
bptjm-28	22	31	patients	patient	NOUN
bptjm-28	22	32	.	.	PUNCT
bptjm-28	23	1	in	in	ADP
bptjm-28	23	2	other	other	ADJ
bptjm-28	23	3	words	word	NOUN
bptjm-28	23	4	,	,	PUNCT
bptjm-28	23	5	these	these	DET
bptjm-28	23	6	studies	study	NOUN
bptjm-28	23	7	experimented	experiment	VERB
bptjm-28	23	8	by	by	ADP
bptjm-28	23	9	adding	add	VERB
bptjm-28	23	10	to	to	ADP
bptjm-28	23	11	the	the	DET
bptjm-28	23	12	protein	protein	NOUN
bptjm-28	23	13	pathway	pathway	NOUN
bptjm-28	23	14	rather	rather	ADV
bptjm-28	23	15	than	than	ADP
bptjm-28	23	16	the	the	DET
bptjm-28	23	17	genes	gene	NOUN
bptjm-28	23	18	of	of	ADP
bptjm-28	23	19	the	the	DET
bptjm-28	23	20	factors	factor	NOUN
bptjm-28	23	21	;	;	PUNCT
bptjm-28	23	22	they	they	PRON
bptjm-28	23	23	added	add	VERB
bptjm-28	23	24	factors	factor	NOUN
bptjm-28	23	25	to	to	PART
bptjm-28	23	26	help	help	VERB
bptjm-28	23	27	build	build	VERB
bptjm-28	23	28	the	the	DET
bptjm-28	23	29	precursors	precursor	NOUN
bptjm-28	23	30	of	of	ADP
bptjm-28	23	31	the	the	DET
bptjm-28	23	32	factors	factor	NOUN
bptjm-28	23	33	or	or	CCONJ
bptjm-28	23	34	necessary	necessary	ADJ
bptjm-28	23	35	stabilizers	stabilizer	NOUN
bptjm-28	23	36	for	for	ADP
bptjm-28	23	37	the	the	DET
bptjm-28	23	38	factors	factor	NOUN
bptjm-28	23	39	.	.	PUNCT
bptjm-28	24	1	one	one	NUM
bptjm-28	24	2	of	of	ADP
bptjm-28	24	3	these	these	DET
bptjm-28	24	4	methods	method	NOUN
bptjm-28	24	5	is	be	AUX
bptjm-28	24	6	called	call	VERB
bptjm-28	24	7	transgene	transgene	ADJ
bptjm-28	24	8	therapies	therapy	NOUN
bptjm-28	24	9	.	.	PUNCT
bptjm-28	25	1	there	there	PRON
bptjm-28	25	2	are	be	VERB
bptjm-28	25	3	many	many	ADJ
bptjm-28	25	4	transgene	transgene	ADJ
bptjm-28	25	5	therapies	therapy	NOUN
bptjm-28	25	6	that	that	PRON
bptjm-28	25	7	evolved	evolve	VERB
bptjm-28	25	8	for	for	ADP
bptjm-28	25	9	various	various	ADJ
bptjm-28	25	10	diseases	disease	NOUN
bptjm-28	25	11	as	as	ADP
bptjm-28	25	12	one	one	NUM
bptjm-28	25	13	berkeley	berkeley	PROPN
bptjm-28	25	14	pharma	pharma	PROPN
bptjm-28	25	15	tech	tech	NOUN
bptjm-28	25	16	journal	journal	NOUN
bptjm-28	25	17	of	of	ADP
bptjm-28	25	18	medicine	medicine	NOUN
bptjm-28	25	19	|	|	ADV
bptjm-28	25	20	121	121	NUM
bptjm-28	25	21	study	study	NOUN
bptjm-28	25	22	suggests8	suggests8	NOUN
bptjm-28	25	23	.	.	PUNCT
bptjm-28	26	1	one	one	NUM
bptjm-28	26	2	of	of	ADP
bptjm-28	26	3	the	the	DET
bptjm-28	26	4	transgene	transgene	ADJ
bptjm-28	26	5	therapies	therapy	NOUN
bptjm-28	26	6	is	be	AUX
bptjm-28	26	7	the	the	DET
bptjm-28	26	8	fix	fix	NOUN
bptjm-28	26	9	-	-	PUNCT
bptjm-28	26	10	pauda	pauda	NOUN
bptjm-28	26	11	and	and	CCONJ
bptjm-28	26	12	robinhood	robinhood	PROPN
bptjm-28	26	13	gene	gene	NOUN
bptjm-28	26	14	therapy	therapy	NOUN
bptjm-28	26	15	which	which	PRON
bptjm-28	26	16	in	in	ADP
bptjm-28	26	17	short	short	ADJ
bptjm-28	26	18	is	be	AUX
bptjm-28	26	19	the	the	DET
bptjm-28	26	20	transfer	transfer	NOUN
bptjm-28	26	21	of	of	ADP
bptjm-28	26	22	fix	fix	NOUN
bptjm-28	26	23	from	from	ADP
bptjm-28	26	24	a	a	DET
bptjm-28	26	25	patient	patient	NOUN
bptjm-28	26	26	who	who	PRON
bptjm-28	26	27	has	have	VERB
bptjm-28	26	28	an	an	DET
bptjm-28	26	29	abundance	abundance	NOUN
bptjm-28	26	30	of	of	ADP
bptjm-28	26	31	fix	fix	NOUN
bptjm-28	26	32	,	,	PUNCT
bptjm-28	26	33	fix	fix	NOUN
bptjm-28	26	34	-	-	PUNCT
bptjm-28	26	35	padua	padua	NOUN
bptjm-28	26	36	proband	proband	NOUN
bptjm-28	26	37	,	,	PUNCT
bptjm-28	26	38	to	to	ADP
bptjm-28	26	39	a	a	DET
bptjm-28	26	40	patient	patient	NOUN
bptjm-28	26	41	with	with	ADP
bptjm-28	26	42	a	a	DET
bptjm-28	26	43	low	low	ADJ
bptjm-28	26	44	abundance	abundance	NOUN
bptjm-28	26	45	,	,	PUNCT
bptjm-28	26	46	hb	hb	PROPN
bptjm-28	26	47	patients	patient	NOUN
bptjm-28	26	48	.	.	PUNCT
bptjm-28	27	1	this	this	PRON
bptjm-28	27	2	will	will	AUX
bptjm-28	27	3	help	help	VERB
bptjm-28	27	4	hemophilia	hemophilia	NOUN
bptjm-28	27	5	patients	patient	NOUN
bptjm-28	27	6	regain	regain	VERB
bptjm-28	27	7	their	their	PRON
bptjm-28	27	8	fix	fix	NOUN
bptjm-28	27	9	levels	level	NOUN
bptjm-28	27	10	.	.	PUNCT
bptjm-28	28	1	the	the	DET
bptjm-28	28	2	limitation	limitation	NOUN
bptjm-28	28	3	to	to	ADP
bptjm-28	28	4	this	this	DET
bptjm-28	28	5	technique	technique	NOUN
bptjm-28	28	6	is	be	AUX
bptjm-28	28	7	the	the	DET
bptjm-28	28	8	safety	safety	NOUN
bptjm-28	28	9	issue	issue	NOUN
bptjm-28	28	10	of	of	ADP
bptjm-28	28	11	immunogenicity	immunogenicity	NOUN
bptjm-28	28	12	and	and	CCONJ
bptjm-28	28	13	thrombogenicity	thrombogenicity	NOUN
bptjm-28	28	14	as	as	SCONJ
bptjm-28	28	15	the	the	DET
bptjm-28	28	16	doses	dose	NOUN
bptjm-28	28	17	were	be	AUX
bptjm-28	28	18	of	of	ADP
bptjm-28	28	19	concern	concern	NOUN
bptjm-28	28	20	.	.	PUNCT
bptjm-28	29	1	including	include	VERB
bptjm-28	29	2	other	other	ADJ
bptjm-28	29	3	gene	gene	NOUN
bptjm-28	29	4	therapies	therapy	NOUN
bptjm-28	29	5	,	,	PUNCT
bptjm-28	29	6	there	there	PRON
bptjm-28	29	7	are	be	VERB
bptjm-28	29	8	additional	additional	ADJ
bptjm-28	29	9	useful	useful	ADJ
bptjm-28	29	10	therapies	therapy	NOUN
bptjm-28	29	11	not	not	PART
bptjm-28	29	12	using	use	VERB
bptjm-28	29	13	the	the	DET
bptjm-28	29	14	another	another	DET
bptjm-28	29	15	method	method	NOUN
bptjm-28	29	16	explored	explore	VERB
bptjm-28	29	17	was	be	AUX
bptjm-28	29	18	activating	activate	VERB
bptjm-28	29	19	more	more	ADJ
bptjm-28	29	20	of	of	ADP
bptjm-28	29	21	the	the	DET
bptjm-28	29	22	existing	exist	VERB
bptjm-28	29	23	factor	factor	NOUN
bptjm-28	29	24	viii	viii	NOUN
bptjm-28	29	25	if	if	SCONJ
bptjm-28	29	26	they	they	PRON
bptjm-28	29	27	are	be	AUX
bptjm-28	29	28	turned	turn	VERB
bptjm-28	29	29	o	o	NOUN
bptjm-28	29	30	�	�	PROPN
bptjm-28	29	31	in	in	ADP
bptjm-28	29	32	presence	presence	NOUN
bptjm-28	29	33	of	of	ADP
bptjm-28	29	34	thrombosis	thrombosis	NOUN
bptjm-28	29	35	,	,	PUNCT
bptjm-28	29	36	such	such	ADJ
bptjm-28	29	37	as	as	ADP
bptjm-28	29	38	an	an	DET
bptjm-28	29	39	inducible	inducible	ADJ
bptjm-28	29	40	vector	vector	NOUN
bptjm-28	29	41	.	.	PUNCT
bptjm-28	30	1	factor	factor	NOUN
bptjm-28	30	2	viii	viii	NOUN
bptjm-28	30	3	is	be	AUX
bptjm-28	30	4	a	a	DET
bptjm-28	30	5	cofactor	cofactor	NOUN
bptjm-28	30	6	in	in	ADP
bptjm-28	30	7	the	the	DET
bptjm-28	30	8	coagulation	coagulation	NOUN
bptjm-28	30	9	cascade	cascade	NOUN
bptjm-28	30	10	and	and	CCONJ
bptjm-28	30	11	is	be	AUX
bptjm-28	30	12	primarily	primarily	ADV
bptjm-28	30	13	produced	produce	VERB
bptjm-28	30	14	by	by	ADP
bptjm-28	30	15	endothelial	endothelial	ADJ
bptjm-28	30	16	cells	cell	NOUN
bptjm-28	30	17	.	.	PUNCT
bptjm-28	31	1	a	a	DET
bptjm-28	31	2	study	study	NOUN
bptjm-28	31	3	by	by	ADP
bptjm-28	31	4	alam	alam	PROPN
bptjm-28	31	5	et	et	PROPN
bptjm-28	31	6	.	.	PUNCT
bptjm-28	32	1	al	al	PROPN
bptjm-28	32	2	.	.	PROPN
bptjm-28	32	3	observed	observe	VERB
bptjm-28	32	4	that	that	SCONJ
bptjm-28	32	5	because	because	SCONJ
bptjm-28	32	6	thrombin	thrombin	NOUN
bptjm-28	32	7	regenerates	regenerate	VERB
bptjm-28	32	8	itself	itself	PRON
bptjm-28	32	9	with	with	ADP
bptjm-28	32	10	the	the	DET
bptjm-28	32	11	increased	increase	VERB
bptjm-28	32	12	amount	amount	NOUN
bptjm-28	32	13	of	of	ADP
bptjm-28	32	14	platelets	platelet	NOUN
bptjm-28	32	15	and	and	CCONJ
bptjm-28	32	16	itself	itself	PRON
bptjm-28	32	17	in	in	ADP
bptjm-28	32	18	the	the	DET
bptjm-28	32	19	blood	blood	NOUN
bptjm-28	32	20	in	in	ADP
bptjm-28	32	21	the	the	DET
bptjm-28	32	22	coagulation	coagulation	NOUN
bptjm-28	32	23	cascade	cascade	NOUN
bptjm-28	32	24	it	it	PRON
bptjm-28	32	25	is	be	AUX
bptjm-28	32	26	important	important	ADJ
bptjm-28	32	27	to	to	PART
bptjm-28	32	28	have	have	VERB
bptjm-28	32	29	thrombin	thrombin	NOUN
bptjm-28	32	30	in	in	ADP
bptjm-28	32	31	the	the	DET
bptjm-28	32	32	body	body	NOUN
bptjm-28	32	33	.	.	PUNCT
bptjm-28	33	1	by	by	ADP
bptjm-28	33	2	endothelial	endothelial	ADJ
bptjm-28	33	3	injury	injury	NOUN
bptjm-28	33	4	the	the	DET
bptjm-28	33	5	release	release	NOUN
bptjm-28	33	6	of	of	ADP
bptjm-28	33	7	thrombin	thrombin	NOUN
bptjm-28	33	8	will	will	AUX
bptjm-28	33	9	amplify	amplify	VERB
bptjm-28	33	10	the	the	DET
bptjm-28	33	11	activation	activation	NOUN
bptjm-28	33	12	of	of	ADP
bptjm-28	33	13	factor	factor	NOUN
bptjm-28	33	14	viii	viii	VERB
bptjm-28	33	15	by	by	ADP
bptjm-28	33	16	re	re	NOUN
bptjm-28	33	17	-	-	NOUN
bptjm-28	33	18	detachment	detachment	NOUN
bptjm-28	33	19	of	of	ADP
bptjm-28	33	20	factor	factor	NOUN
bptjm-28	33	21	viii	viii	NOUN
bptjm-28	33	22	from	from	ADP
bptjm-28	33	23	the	the	DET
bptjm-28	33	24	von	von	PROPN
bptjm-28	33	25	willebrand	willebrand	NOUN
bptjm-28	33	26	factor	factor	NOUN
bptjm-28	33	27	and	and	CCONJ
bptjm-28	33	28	factor	factor	NOUN
bptjm-28	33	29	viii	viii	NOUN
bptjm-28	33	30	complex	complex	NOUN
bptjm-28	33	31	.	.	PUNCT
bptjm-28	34	1	two	two	NUM
bptjm-28	34	2	patients	patient	NOUN
bptjm-28	34	3	who	who	PRON
bptjm-28	34	4	had	have	AUX
bptjm-28	34	5	undergone	undergo	VERB
bptjm-28	34	6	both	both	CCONJ
bptjm-28	34	7	arterial	arterial	NOUN
bptjm-28	34	8	and	and	CCONJ
bptjm-28	34	9	venous	venous	ADJ
bptjm-28	34	10	thrombotic	thrombotic	ADJ
bptjm-28	34	11	events	event	NOUN
bptjm-28	34	12	before	before	ADP
bptjm-28	34	13	observing	observe	VERB
bptjm-28	34	14	an	an	DET
bptjm-28	34	15	increase	increase	NOUN
bptjm-28	34	16	in	in	ADP
bptjm-28	34	17	factor	factor	NOUN
bptjm-28	34	18	viii9	viii9	PROPN
bptjm-28	34	19	.	.	PUNCT
bptjm-28	35	1	von	von	PROPN
bptjm-28	35	2	willebrand	willebrand	PROPN
bptjm-28	35	3	factor	factor	NOUN
bptjm-28	35	4	(	(	PUNCT
bptjm-28	35	5	vwf	vwf	NOUN
bptjm-28	35	6	)	)	PUNCT
bptjm-28	35	7	is	be	AUX
bptjm-28	35	8	a	a	DET
bptjm-28	35	9	major	major	ADJ
bptjm-28	35	10	contributing	contribute	VERB
bptjm-28	35	11	factor	factor	NOUN
bptjm-28	35	12	to	to	ADP
bptjm-28	35	13	the	the	DET
bptjm-28	35	14	availability	availability	NOUN
bptjm-28	35	15	of	of	ADP
bptjm-28	35	16	factor	factor	NOUN
bptjm-28	35	17	viii	viii	NOUN
bptjm-28	35	18	(	(	PUNCT
bptjm-28	35	19	fviii	fviii	NOUN
bptjm-28	35	20	)	)	PUNCT
bptjm-28	35	21	as	as	SCONJ
bptjm-28	35	22	vwf	vwf	NOUN
bptjm-28	35	23	is	be	AUX
bptjm-28	35	24	a	a	DET
bptjm-28	35	25	speci	speci	ADJ
bptjm-28	35	26	�	�	PROPN
bptjm-28	35	27	c	c	PROPN
bptjm-28	35	28	carrier	carrier	NOUN
bptjm-28	35	29	protein	protein	NOUN
bptjm-28	35	30	that	that	PRON
bptjm-28	35	31	protects	protect	VERB
bptjm-28	35	32	fviii	fviii	NOUN
bptjm-28	35	33	of	of	ADP
bptjm-28	35	34	proteolytic	proteolytic	ADJ
bptjm-28	35	35	enzymes	enzyme	NOUN
bptjm-28	35	36	and	and	CCONJ
bptjm-28	35	37	from	from	ADP
bptjm-28	35	38	degradation10	degradation10	NOUN
bptjm-28	35	39	.	.	PUNCT
bptjm-28	36	1	this	this	DET
bptjm-28	36	2	insight	insight	NOUN
bptjm-28	36	3	of	of	ADP
bptjm-28	36	4	the	the	DET
bptjm-28	36	5	activation	activation	NOUN
bptjm-28	36	6	of	of	ADP
bptjm-28	36	7	factor	factor	NOUN
bptjm-28	36	8	viii	viii	NOUN
bptjm-28	36	9	suggests	suggest	VERB
bptjm-28	36	10	that	that	SCONJ
bptjm-28	36	11	there	there	PRON
bptjm-28	36	12	might	might	AUX
bptjm-28	36	13	be	be	AUX
bptjm-28	36	14	an	an	DET
bptjm-28	36	15	activation	activation	NOUN
bptjm-28	36	16	method	method	NOUN
bptjm-28	36	17	to	to	PART
bptjm-28	36	18	make	make	VERB
bptjm-28	36	19	the	the	DET
bptjm-28	36	20	factor	factor	NOUN
bptjm-28	36	21	viii	viii	NOUN
bptjm-28	36	22	protein	protein	NOUN
bptjm-28	36	23	more	more	ADV
bptjm-28	36	24	readily	readily	ADV
bptjm-28	36	25	available	available	ADJ
bptjm-28	36	26	to	to	ADP
bptjm-28	36	27	the	the	DET
bptjm-28	36	28	coagulation	coagulation	NOUN
bptjm-28	36	29	cascade	cascade	NOUN
bptjm-28	36	30	and	and	CCONJ
bptjm-28	36	31	help	help	NOUN
bptjm-28	36	32	with	with	ADP
bptjm-28	36	33	blood	blood	NOUN
bptjm-28	36	34	clotting	clotting	NOUN
bptjm-28	36	35	.	.	PUNCT
bptjm-28	37	1	this	this	PRON
bptjm-28	37	2	activating	activate	VERB
bptjm-28	37	3	more	more	ADJ
bptjm-28	37	4	of	of	ADP
bptjm-28	37	5	the	the	DET
bptjm-28	37	6	existing	exist	VERB
bptjm-28	37	7	factor	factor	NOUN
bptjm-28	37	8	viii	viii	NOUN
bptjm-28	37	9	if	if	SCONJ
bptjm-28	37	10	they	they	PRON
bptjm-28	37	11	are	be	AUX
bptjm-28	37	12	turned	turn	VERB
bptjm-28	37	13	o	o	NOUN
bptjm-28	37	14	�	�	PROPN
bptjm-28	37	15	in	in	ADP
bptjm-28	37	16	presence	presence	NOUN
bptjm-28	37	17	of	of	ADP
bptjm-28	37	18	thrombosis	thrombosis	NOUN
bptjm-28	37	19	can	can	AUX
bptjm-28	37	20	prove	prove	VERB
bptjm-28	37	21	to	to	PART
bptjm-28	37	22	be	be	AUX
bptjm-28	37	23	a	a	DET
bptjm-28	37	24	consideration	consideration	NOUN
bptjm-28	37	25	in	in	ADP
bptjm-28	37	26	hemophiliac	hemophiliac	ADJ
bptjm-28	37	27	studies	study	NOUN
bptjm-28	37	28	.	.	PUNCT
bptjm-28	38	1	another	another	DET
bptjm-28	38	2	study	study	NOUN
bptjm-28	38	3	also	also	ADV
bptjm-28	38	4	included	include	VERB
bptjm-28	38	5	alternating	alternate	VERB
bptjm-28	38	6	the	the	DET
bptjm-28	38	7	amino	amino	ADJ
bptjm-28	38	8	acids	acid	NOUN
bptjm-28	38	9	on	on	ADP
bptjm-28	38	10	factor	factor	NOUN
bptjm-28	38	11	viii	viii	NOUN
bptjm-28	38	12	will	will	AUX
bptjm-28	38	13	make	make	VERB
bptjm-28	38	14	it	it	PRON
bptjm-28	38	15	more	more	ADV
bptjm-28	38	16	readily	readily	ADV
bptjm-28	38	17	activated	activate	VERB
bptjm-28	38	18	.	.	PUNCT
bptjm-28	39	1	a	a	DET
bptjm-28	39	2	study	study	NOUN
bptjm-28	39	3	by	by	ADP
bptjm-28	39	4	nogami	nogami	NOUN
bptjm-28	39	5	et.al	et.al	PROPN
bptjm-28	39	6	.	.	PUNCT
bptjm-28	39	7	conducted	conduct	VERB
bptjm-28	39	8	an	an	DET
bptjm-28	39	9	in	in	ADP
bptjm-28	39	10	vivo	vivo	NOUN
bptjm-28	39	11	experiment	experiment	NOUN
bptjm-28	39	12	which	which	PRON
bptjm-28	39	13	included	include	VERB
bptjm-28	39	14	altering	alter	VERB
bptjm-28	39	15	the	the	DET
bptjm-28	39	16	372	372	NUM
bptjm-28	39	17	amino	amino	NOUN
bptjm-28	39	18	acid	acid	NOUN
bptjm-28	39	19	position	position	NOUN
bptjm-28	39	20	of	of	ADP
bptjm-28	39	21	an	an	DET
bptjm-28	39	22	arginine	arginine	NOUN
bptjm-28	39	23	protein	protein	NOUN
bptjm-28	39	24	on	on	ADP
bptjm-28	39	25	the	the	DET
bptjm-28	39	26	factor	factor	NOUN
bptjm-28	39	27	viii	viii	NOUN
bptjm-28	39	28	protein	protein	NOUN
bptjm-28	39	29	to	to	ADP
bptjm-28	39	30	a	a	DET
bptjm-28	39	31	histidine	histidine	ADJ
bptjm-28	39	32	protein	protein	NOUN
bptjm-28	39	33	to	to	PART
bptjm-28	39	34	make	make	VERB
bptjm-28	39	35	it	it	PRON
bptjm-28	39	36	more	more	ADV
bptjm-28	39	37	detachable	detachable	ADJ
bptjm-28	39	38	from	from	ADP
bptjm-28	39	39	the	the	DET
bptjm-28	39	40	vwf	vwf	NOUN
bptjm-28	39	41	-	-	PUNCT
bptjm-28	39	42	fviii	fviii	NOUN
bptjm-28	39	43	complex	complex	NOUN
bptjm-28	39	44	.	.	PUNCT
bptjm-28	40	1	although	although	SCONJ
bptjm-28	40	2	this	this	PRON
bptjm-28	40	3	is	be	AUX
bptjm-28	40	4	a	a	DET
bptjm-28	40	5	novel	novel	NOUN
bptjm-28	40	6	in	in	ADP
bptjm-28	40	7	vivo	vivo	NOUN
bptjm-28	40	8	approach	approach	NOUN
bptjm-28	40	9	,	,	PUNCT
bptjm-28	40	10	the	the	DET
bptjm-28	40	11	study	study	NOUN
bptjm-28	40	12	saw	see	VERB
bptjm-28	40	13	little	little	ADJ
bptjm-28	40	14	to	to	ADP
bptjm-28	40	15	no	no	DET
bptjm-28	40	16	change	change	NOUN
bptjm-28	40	17	in	in	ADP
bptjm-28	40	18	the	the	DET
bptjm-28	40	19	cleavage	cleavage	NOUN
bptjm-28	40	20	rate	rate	NOUN
bptjm-28	40	21	with	with	ADP
bptjm-28	40	22	the	the	DET
bptjm-28	40	23	amino	amino	NOUN
bptjm-28	40	24	acid	acid	NOUN
bptjm-28	40	25	change	change	NOUN
bptjm-28	40	26	suggesting	suggest	VERB
bptjm-28	40	27	that	that	SCONJ
bptjm-28	40	28	there	there	PRON
bptjm-28	40	29	may	may	AUX
bptjm-28	40	30	be	be	AUX
bptjm-28	40	31	other	other	ADJ
bptjm-28	40	32	properties	property	NOUN
bptjm-28	40	33	associated	associate	VERB
bptjm-28	40	34	with	with	ADP
bptjm-28	40	35	the	the	DET
bptjm-28	40	36	thrombin	thrombin	NOUN
bptjm-28	40	37	and	and	CCONJ
bptjm-28	40	38	the	the	DET
bptjm-28	40	39	vwf	vwf	NOUN
bptjm-28	40	40	-	-	PUNCT
bptjm-28	40	41	fviii	fviii	NOUN
bptjm-28	40	42	complex	complex	ADJ
bptjm-28	40	43	cleavage	cleavage	NOUN
bptjm-28	40	44	mechanism11	mechanism11	NOUN
bptjm-28	40	45	.	.	PUNCT
bptjm-28	41	1	this	this	DET
bptjm-28	41	2	inducible	inducible	ADJ
bptjm-28	41	3	mechanism	mechanism	NOUN
bptjm-28	41	4	can	can	AUX
bptjm-28	41	5	also	also	ADV
bptjm-28	41	6	be	be	AUX
bptjm-28	41	7	used	use	VERB
bptjm-28	41	8	in	in	ADP
bptjm-28	41	9	the	the	DET
bptjm-28	41	10	aav	aav	NOUN
bptjm-28	41	11	vector	vector	NOUN
bptjm-28	41	12	that	that	PRON
bptjm-28	41	13	is	be	AUX
bptjm-28	41	14	an	an	DET
bptjm-28	41	15	emerging	emerge	VERB
bptjm-28	41	16	technology	technology	NOUN
bptjm-28	41	17	.	.	PUNCT
bptjm-28	42	1	these	these	DET
bptjm-28	42	2	mechanisms	mechanism	NOUN
bptjm-28	42	3	are	be	AUX
bptjm-28	42	4	sin	sin	NOUN
bptjm-28	42	5	berkeley	berkeley	PROPN
bptjm-28	42	6	pharma	pharma	PROPN
bptjm-28	42	7	tech	tech	NOUN
bptjm-28	42	8	journal	journal	NOUN
bptjm-28	42	9	of	of	ADP
bptjm-28	42	10	medicine	medicine	NOUN
bptjm-28	42	11	|	|	ADV
bptjm-28	42	12	122	122	NUM
bptjm-28	42	13	vectors	vector	NOUN
bptjm-28	42	14	which	which	PRON
bptjm-28	42	15	contain	contain	VERB
bptjm-28	42	16	an	an	DET
bptjm-28	42	17	inducible	inducible	ADJ
bptjm-28	42	18	package	package	NOUN
bptjm-28	42	19	of	of	ADP
bptjm-28	42	20	proteins	protein	NOUN
bptjm-28	42	21	that	that	PRON
bptjm-28	42	22	can	can	AUX
bptjm-28	42	23	turn	turn	VERB
bptjm-28	42	24	the	the	DET
bptjm-28	42	25	expression	expression	NOUN
bptjm-28	42	26	of	of	ADP
bptjm-28	42	27	the	the	DET
bptjm-28	42	28	vector	vector	NOUN
bptjm-28	42	29	on	on	ADP
bptjm-28	42	30	and	and	CCONJ
bptjm-28	42	31	o	o	NOUN
bptjm-28	42	32	�	�	PROPN
bptjm-28	42	33	determined	determine	VERB
bptjm-28	42	34	by	by	ADP
bptjm-28	42	35	a	a	DET
bptjm-28	42	36	protein	protein	NOUN
bptjm-28	42	37	presence	presence	NOUN
bptjm-28	42	38	.	.	PUNCT
bptjm-28	43	1	particularly	particularly	ADV
bptjm-28	43	2	the	the	DET
bptjm-28	43	3	protein	protein	NOUN
bptjm-28	43	4	would	would	AUX
bptjm-28	43	5	function	function	VERB
bptjm-28	43	6	as	as	ADP
bptjm-28	43	7	an	an	DET
bptjm-28	43	8	antibiotic	antibiotic	NOUN
bptjm-28	43	9	such	such	ADJ
bptjm-28	43	10	as	as	ADP
bptjm-28	43	11	doxycycline	doxycycline	NOUN
bptjm-28	43	12	or	or	CCONJ
bptjm-28	43	13	a	a	DET
bptjm-28	43	14	small	small	ADJ
bptjm-28	43	15	molecule45	molecule45	NOUN
bptjm-28	43	16	.	.	PUNCT
bptjm-28	44	1	furthermore	furthermore	ADV
bptjm-28	44	2	,	,	PUNCT
bptjm-28	44	3	another	another	DET
bptjm-28	44	4	method	method	NOUN
bptjm-28	44	5	that	that	PRON
bptjm-28	44	6	was	be	AUX
bptjm-28	44	7	proven	prove	VERB
bptjm-28	44	8	to	to	PART
bptjm-28	44	9	be	be	AUX
bptjm-28	44	10	e	e	NOUN
bptjm-28	44	11	�	�	NOUN
bptjm-28	44	12	ective	ective	NOUN
bptjm-28	44	13	is	be	AUX
bptjm-28	44	14	site	site	NOUN
bptjm-28	44	15	-	-	PUNCT
bptjm-28	44	16	speci	speci	ADJ
bptjm-28	44	17	�	�	PROPN
bptjm-28	44	18	c	c	NOUN
bptjm-28	44	19	bioconjugation	bioconjugation	NOUN
bptjm-28	44	20	which	which	PRON
bptjm-28	44	21	alters	alter	VERB
bptjm-28	44	22	the	the	DET
bptjm-28	44	23	activation	activation	NOUN
bptjm-28	44	24	of	of	ADP
bptjm-28	44	25	factor	factor	NOUN
bptjm-28	44	26	vii	vii	PROPN
bptjm-28	44	27	which	which	PRON
bptjm-28	44	28	triggers	trigger	VERB
bptjm-28	44	29	the	the	DET
bptjm-28	44	30	whole	whole	ADJ
bptjm-28	44	31	cascade	cascade	NOUN
bptjm-28	44	32	of	of	ADP
bptjm-28	44	33	coagulation	coagulation	NOUN
bptjm-28	44	34	as	as	SCONJ
bptjm-28	44	35	suggested	suggest	VERB
bptjm-28	44	36	by	by	ADP
bptjm-28	44	37	lieser	lieser	PROPN
bptjm-28	44	38	et	et	NOUN
bptjm-28	44	39	.	.	PUNCT
bptjm-28	45	1	al12	al12	PROPN
bptjm-28	45	2	.	.	PUNCT
bptjm-28	46	1	another	another	DET
bptjm-28	46	2	type	type	NOUN
bptjm-28	46	3	of	of	ADP
bptjm-28	46	4	therapy	therapy	NOUN
bptjm-28	46	5	that	that	PRON
bptjm-28	46	6	was	be	AUX
bptjm-28	46	7	proven	prove	VERB
bptjm-28	46	8	successful	successful	ADJ
bptjm-28	46	9	by	by	ADP
bptjm-28	46	10	clinical	clinical	ADJ
bptjm-28	46	11	trials	trial	NOUN
bptjm-28	46	12	of	of	ADP
bptjm-28	46	13	di	di	NOUN
bptjm-28	46	14	�	�	PROPN
bptjm-28	46	15	erent	erent	NOUN
bptjm-28	46	16	companies	company	NOUN
bptjm-28	46	17	as	as	SCONJ
bptjm-28	46	18	suggested	suggest	VERB
bptjm-28	46	19	by	by	ADP
bptjm-28	46	20	a	a	DET
bptjm-28	46	21	review	review	NOUN
bptjm-28	46	22	article	article	NOUN
bptjm-28	46	23	by	by	ADP
bptjm-28	46	24	sadiki	sadiki	PROPN
bptjm-28	46	25	et	et	PROPN
bptjm-28	46	26	.	.	PUNCT
bptjm-28	47	1	al	al	PROPN
bptjm-28	47	2	..	..	PROPN
bptjm-28	47	3	site	site	PROPN
bptjm-28	47	4	-	-	PUNCT
bptjm-28	47	5	speci	speci	NOUN
bptjm-28	47	6	�	�	PROPN
bptjm-28	47	7	c	c	NOUN
bptjm-28	47	8	bioconjugation	bioconjugation	NOUN
bptjm-28	47	9	is	be	AUX
bptjm-28	47	10	the	the	DET
bptjm-28	47	11	concept	concept	NOUN
bptjm-28	47	12	of	of	ADP
bptjm-28	47	13	aiding	aid	VERB
bptjm-28	47	14	the	the	DET
bptjm-28	47	15	speci	speci	PROPN
bptjm-28	47	16	�	�	PROPN
bptjm-28	47	17	c	c	NOUN
bptjm-28	47	18	proteins	protein	NOUN
bptjm-28	47	19	needed	need	VERB
bptjm-28	47	20	for	for	ADP
bptjm-28	47	21	delivery	delivery	NOUN
bptjm-28	47	22	of	of	ADP
bptjm-28	47	23	drug	drug	NOUN
bptjm-28	47	24	carriers	carrier	NOUN
bptjm-28	47	25	and	and	CCONJ
bptjm-28	47	26	moieties	moiety	NOUN
bptjm-28	47	27	of	of	ADP
bptjm-28	47	28	proteins	protein	NOUN
bptjm-28	47	29	within	within	ADP
bptjm-28	47	30	the	the	DET
bptjm-28	47	31	body	body	NOUN
bptjm-28	47	32	.	.	PUNCT
bptjm-28	48	1	this	this	DET
bptjm-28	48	2	technology	technology	NOUN
bptjm-28	48	3	increases	increase	VERB
bptjm-28	48	4	protein	protein	NOUN
bptjm-28	48	5	circulation	circulation	NOUN
bptjm-28	48	6	,	,	PUNCT
bptjm-28	48	7	activity	activity	NOUN
bptjm-28	48	8	,	,	PUNCT
bptjm-28	48	9	target	target	NOUN
bptjm-28	48	10	speci	speci	PROPN
bptjm-28	48	11	�	�	PROPN
bptjm-28	48	12	city	city	NOUN
bptjm-28	48	13	,	,	PUNCT
bptjm-28	48	14	and	and	CCONJ
bptjm-28	48	15	protein	protein	NOUN
bptjm-28	48	16	properties	property	NOUN
bptjm-28	48	17	as	as	ADP
bptjm-28	48	18	a	a	DET
bptjm-28	48	19	whole	whole	NOUN
bptjm-28	48	20	.	.	PUNCT
bptjm-28	49	1	there	there	PRON
bptjm-28	49	2	are	be	VERB
bptjm-28	49	3	many	many	ADJ
bptjm-28	49	4	site	site	NOUN
bptjm-28	49	5	-	-	PUNCT
bptjm-28	49	6	speci	speci	ADJ
bptjm-28	49	7	�	�	PROPN
bptjm-28	49	8	c	c	NOUN
bptjm-28	49	9	bioconjugations	bioconjugation	NOUN
bptjm-28	49	10	which	which	PRON
bptjm-28	49	11	include	include	VERB
bptjm-28	49	12	unnatural	unnatural	ADJ
bptjm-28	49	13	amino	amino	NOUN
bptjm-28	49	14	acid	acid	NOUN
bptjm-28	49	15	incorporation	incorporation	NOUN
bptjm-28	49	16	,	,	PUNCT
bptjm-28	49	17	sortase	sortase	NOUN
bptjm-28	49	18	-	-	PUNCT
bptjm-28	49	19	mediated	mediate	VERB
bptjm-28	49	20	ligation	ligation	NOUN
bptjm-28	49	21	,	,	PUNCT
bptjm-28	49	22	and	and	CCONJ
bptjm-28	49	23	spycatcher	spycatcher	ADJ
bptjm-28	49	24	/	/	SYM
bptjm-28	49	25	spytag	spytag	NOUN
bptjm-28	49	26	bioconjugation	bioconjugation	NOUN
bptjm-28	49	27	.	.	PUNCT
bptjm-28	50	1	all	all	PRON
bptjm-28	50	2	of	of	ADP
bptjm-28	50	3	these	these	DET
bptjm-28	50	4	methods	method	NOUN
bptjm-28	50	5	make	make	VERB
bptjm-28	50	6	alterations	alteration	NOUN
bptjm-28	50	7	to	to	ADP
bptjm-28	50	8	the	the	DET
bptjm-28	50	9	amino	amino	NOUN
bptjm-28	50	10	acids	acid	NOUN
bptjm-28	50	11	present	present	NOUN
bptjm-28	50	12	in	in	ADP
bptjm-28	50	13	a	a	DET
bptjm-28	50	14	particular	particular	ADJ
bptjm-28	50	15	drug	drug	NOUN
bptjm-28	50	16	carrier	carrier	NOUN
bptjm-28	50	17	making	make	VERB
bptjm-28	50	18	the	the	DET
bptjm-28	50	19	permeability	permeability	NOUN
bptjm-28	50	20	of	of	ADP
bptjm-28	50	21	that	that	DET
bptjm-28	50	22	drug	drug	NOUN
bptjm-28	50	23	easier	easy	ADJ
bptjm-28	50	24	in	in	ADP
bptjm-28	50	25	the	the	DET
bptjm-28	50	26	body	body	NOUN
bptjm-28	50	27	.	.	PUNCT
bptjm-28	51	1	this	this	DET
bptjm-28	51	2	method	method	NOUN
bptjm-28	51	3	is	be	AUX
bptjm-28	51	4	favorable	favorable	ADJ
bptjm-28	51	5	because	because	SCONJ
bptjm-28	51	6	it	it	PRON
bptjm-28	51	7	changes	change	VERB
bptjm-28	51	8	the	the	DET
bptjm-28	51	9	way	way	NOUN
bptjm-28	51	10	particular	particular	ADJ
bptjm-28	51	11	factors	factor	NOUN
bptjm-28	51	12	and	and	CCONJ
bptjm-28	51	13	proteins	protein	NOUN
bptjm-28	51	14	are	be	AUX
bptjm-28	51	15	delivered	deliver	VERB
bptjm-28	51	16	to	to	ADP
bptjm-28	51	17	the	the	DET
bptjm-28	51	18	body	body	NOUN
bptjm-28	51	19	without	without	ADP
bptjm-28	51	20	recombinant	recombinant	ADJ
bptjm-28	51	21	engineering13	engineering13	NOUN
bptjm-28	51	22	.	.	PUNCT
bptjm-28	52	1	jivi	jivi	PROPN
bptjm-28	52	2	is	be	AUX
bptjm-28	52	3	an	an	DET
bptjm-28	52	4	antihemophilic	antihemophilic	ADJ
bptjm-28	52	5	factor	factor	NOUN
bptjm-28	52	6	(	(	PUNCT
bptjm-28	52	7	recombinant	recombinant	ADJ
bptjm-28	52	8	)	)	PUNCT
bptjm-28	52	9	gene	gene	NOUN
bptjm-28	52	10	or	or	CCONJ
bptjm-28	52	11	a	a	DET
bptjm-28	52	12	factor	factor	NOUN
bptjm-28	52	13	viii	viii	NOUN
bptjm-28	52	14	concentrate	concentrate	NOUN
bptjm-28	52	15	.	.	PUNCT
bptjm-28	53	1	this	this	DET
bptjm-28	53	2	study	study	NOUN
bptjm-28	53	3	focused	focus	VERB
bptjm-28	53	4	on	on	ADP
bptjm-28	53	5	reducing	reduce	VERB
bptjm-28	53	6	the	the	DET
bptjm-28	53	7	amount	amount	NOUN
bptjm-28	53	8	of	of	ADP
bptjm-28	53	9	times	time	NOUN
bptjm-28	53	10	patients	patient	NOUN
bptjm-28	53	11	need	need	VERB
bptjm-28	53	12	to	to	PART
bptjm-28	53	13	have	have	VERB
bptjm-28	53	14	routine	routine	ADJ
bptjm-28	53	15	prophylaxis	prophylaxis	NOUN
bptjm-28	53	16	by	by	ADP
bptjm-28	53	17	making	make	VERB
bptjm-28	53	18	an	an	DET
bptjm-28	53	19	on	on	ADP
bptjm-28	53	20	-	-	PUNCT
bptjm-28	53	21	demand	demand	NOUN
bptjm-28	53	22	treatment	treatment	NOUN
bptjm-28	53	23	to	to	PART
bptjm-28	53	24	control	control	VERB
bptjm-28	53	25	the	the	DET
bptjm-28	53	26	bleeding	bleeding	NOUN
bptjm-28	53	27	.	.	PUNCT
bptjm-28	54	1	they	they	PRON
bptjm-28	54	2	used	use	VERB
bptjm-28	54	3	recombinant	recombinant	ADJ
bptjm-28	54	4	dna	dna	NOUN
bptjm-28	54	5	technology	technology	NOUN
bptjm-28	54	6	in	in	ADP
bptjm-28	54	7	baby	baby	NOUN
bptjm-28	54	8	hamster	hamster	PROPN
bptjm-28	54	9	kidney	kidney	PROPN
bptjm-28	54	10	(	(	PUNCT
bptjm-28	54	11	bhk	bhk	PROPN
bptjm-28	54	12	)	)	PUNCT
bptjm-28	54	13	cells	cell	NOUN
bptjm-28	54	14	to	to	PART
bptjm-28	54	15	generate	generate	VERB
bptjm-28	54	16	the	the	DET
bptjm-28	54	17	recombinant	recombinant	ADJ
bptjm-28	54	18	b	b	NOUN
bptjm-28	54	19	-	-	PUNCT
bptjm-28	54	20	domain	domain	NOUN
bptjm-28	54	21	deleted	delete	VERB
bptjm-28	54	22	human	human	ADJ
bptjm-28	54	23	coagulation	coagulation	NOUN
bptjm-28	54	24	factor	factor	NOUN
bptjm-28	54	25	viii	viii	NOUN
bptjm-28	54	26	(	(	PUNCT
bptjm-28	54	27	bdd	bdd	NOUN
bptjm-28	54	28	-	-	PUNCT
bptjm-28	54	29	rfviii	rfviii	NOUN
bptjm-28	54	30	)	)	PUNCT
bptjm-28	54	31	to	to	PART
bptjm-28	54	32	obtain	obtain	VERB
bptjm-28	54	33	the	the	DET
bptjm-28	54	34	activated	activate	VERB
bptjm-28	54	35	molecule	molecule	NOUN
bptjm-28	54	36	.	.	PUNCT
bptjm-28	55	1	due	due	ADP
bptjm-28	55	2	to	to	ADP
bptjm-28	55	3	its	its	PRON
bptjm-28	55	4	on	on	ADP
bptjm-28	55	5	-	-	PUNCT
bptjm-28	55	6	demand	demand	NOUN
bptjm-28	55	7	property	property	NOUN
bptjm-28	55	8	,	,	PUNCT
bptjm-28	55	9	it	it	PRON
bptjm-28	55	10	can	can	AUX
bptjm-28	55	11	also	also	ADV
bptjm-28	55	12	be	be	AUX
bptjm-28	55	13	used	use	VERB
bptjm-28	55	14	as	as	ADP
bptjm-28	55	15	a	a	DET
bptjm-28	55	16	perioperative	perioperative	ADJ
bptjm-28	55	17	treatment	treatment	NOUN
bptjm-28	55	18	plan	plan	NOUN
bptjm-28	55	19	in	in	ADP
bptjm-28	55	20	the	the	DET
bptjm-28	55	21	means	mean	NOUN
bptjm-28	55	22	of	of	ADP
bptjm-28	55	23	managing	manage	VERB
bptjm-28	55	24	bleeding	bleed	VERB
bptjm-28	55	25	before	before	ADP
bptjm-28	55	26	surgery	surgery	NOUN
bptjm-28	55	27	based	base	VERB
bptjm-28	55	28	on	on	ADP
bptjm-28	55	29	the	the	DET
bptjm-28	55	30	patient	patient	NOUN
bptjm-28	55	31	's	's	PART
bptjm-28	55	32	needs	need	NOUN
bptjm-28	55	33	.	.	PUNCT
bptjm-28	56	1	in	in	ADP
bptjm-28	56	2	terms	term	NOUN
bptjm-28	56	3	of	of	ADP
bptjm-28	56	4	hemophilia	hemophilia	NOUN
bptjm-28	56	5	,	,	PUNCT
bptjm-28	56	6	this	this	DET
bptjm-28	56	7	study	study	NOUN
bptjm-28	56	8	and	and	CCONJ
bptjm-28	56	9	product	product	NOUN
bptjm-28	56	10	took	take	VERB
bptjm-28	56	11	into	into	ADP
bptjm-28	56	12	consideration	consideration	NOUN
bptjm-28	56	13	the	the	DET
bptjm-28	56	14	intensity	intensity	NOUN
bptjm-28	56	15	of	of	ADP
bptjm-28	56	16	bleeding	bleeding	NOUN
bptjm-28	56	17	of	of	ADP
bptjm-28	56	18	patients	patient	NOUN
bptjm-28	56	19	with	with	ADP
bptjm-28	56	20	hemophilia	hemophilia	NOUN
bptjm-28	56	21	and	and	CCONJ
bptjm-28	56	22	treated	treat	VERB
bptjm-28	56	23	people	people	NOUN
bptjm-28	56	24	with	with	ADP
bptjm-28	56	25	severe	severe	ADJ
bptjm-28	56	26	hemophilia	hemophilia	NOUN
bptjm-28	56	27	(	(	PUNCT
bptjm-28	56	28	two	two	NUM
bptjm-28	56	29	or	or	CCONJ
bptjm-28	56	30	more	more	ADJ
bptjm-28	56	31	bleeds	bleed	NOUN
bptjm-28	56	32	per	per	ADP
bptjm-28	56	33	week	week	NOUN
bptjm-28	56	34	)	)	PUNCT
bptjm-28	56	35	two	two	NUM
bptjm-28	56	36	times	time	NOUN
bptjm-28	56	37	weekly	weekly	ADJ
bptjm-28	56	38	30	30	NUM
bptjm-28	56	39	-	-	SYM
bptjm-28	56	40	40	40	NUM
bptjm-28	56	41	iu	iu	PROPN
bptjm-28	56	42	/	/	SYM
bptjm-28	56	43	kg	kg	NOUN
bptjm-28	56	44	.	.	PUNCT
bptjm-28	57	1	patients	patient	NOUN
bptjm-28	57	2	with	with	ADP
bptjm-28	57	3	a	a	DET
bptjm-28	57	4	low	low	ADJ
bptjm-28	57	5	bleeding	bleeding	NOUN
bptjm-28	57	6	tendency	tendency	NOUN
bptjm-28	57	7	were	be	AUX
bptjm-28	57	8	treated	treat	VERB
bptjm-28	57	9	every	every	DET
bptjm-28	57	10	5	5	NUM
bptjm-28	57	11	days	day	NOUN
bptjm-28	57	12	or	or	CCONJ
bptjm-28	57	13	twice	twice	ADJ
bptjm-28	57	14	weekly	weekly	ADJ
bptjm-28	57	15	just	just	ADV
bptjm-28	57	16	as	as	SCONJ
bptjm-28	57	17	the	the	DET
bptjm-28	57	18	high	high	ADJ
bptjm-28	57	19	intensity	intensity	NOUN
bptjm-28	57	20	patients	patient	NOUN
bptjm-28	57	21	as	as	SCONJ
bptjm-28	57	22	weekly	weekly	ADJ
bptjm-28	57	23	treatments	treatment	NOUN
bptjm-28	57	24	did	do	AUX
bptjm-28	57	25	not	not	PART
bptjm-28	57	26	show	show	VERB
bptjm-28	57	27	e	e	NOUN
bptjm-28	57	28	�	�	NOUN
bptjm-28	57	29	ciency	ciency	NOUN
bptjm-28	57	30	.	.	PUNCT
bptjm-28	58	1	at	at	ADP
bptjm-28	58	2	the	the	DET
bptjm-28	58	3	end	end	NOUN
bptjm-28	58	4	of	of	ADP
bptjm-28	58	5	the	the	DET
bptjm-28	58	6	study	study	NOUN
bptjm-28	58	7	,	,	PUNCT
bptjm-28	58	8	there	there	PRON
bptjm-28	58	9	was	be	VERB
bptjm-28	58	10	a	a	DET
bptjm-28	58	11	decrease	decrease	NOUN
bptjm-28	58	12	of	of	ADP
bptjm-28	58	13	bleeds	bleed	NOUN
bptjm-28	58	14	per	per	ADP
bptjm-28	58	15	week	week	NOUN
bptjm-28	58	16	in	in	ADP
bptjm-28	58	17	patients	patient	NOUN
bptjm-28	58	18	in	in	ADP
bptjm-28	58	19	total14	total14	PROPN
bptjm-28	58	20	.	.	PUNCT
bptjm-28	59	1	in	in	ADP
bptjm-28	59	2	research	research	NOUN
bptjm-28	59	3	studies	study	NOUN
bptjm-28	59	4	,	,	PUNCT
bptjm-28	59	5	intensity	intensity	NOUN
bptjm-28	59	6	or	or	CCONJ
bptjm-28	59	7	severity	severity	NOUN
bptjm-28	59	8	of	of	ADP
bptjm-28	59	9	hemophilia	hemophilia	NOUN
bptjm-28	59	10	is	be	AUX
bptjm-28	59	11	de	de	X
bptjm-28	59	12	�	�	NOUN
bptjm-28	59	13	ned	ne	VERB
bptjm-28	59	14	by	by	ADP
bptjm-28	59	15	measuring	measure	VERB
bptjm-28	59	16	fviii	fviii	NOUN
bptjm-28	59	17	or	or	CCONJ
bptjm-28	59	18	fix	fix	NOUN
bptjm-28	59	19	activity	activity	NOUN
bptjm-28	59	20	as	as	SCONJ
bptjm-28	59	21	suggested	suggest	VERB
bptjm-28	59	22	by	by	ADP
bptjm-28	59	23	a	a	DET
bptjm-28	59	24	review	review	NOUN
bptjm-28	59	25	paper	paper	NOUN
bptjm-28	59	26	berkeley	berkeley	PROPN
bptjm-28	59	27	pharma	pharma	PROPN
bptjm-28	59	28	tech	tech	NOUN
bptjm-28	59	29	journal	journal	NOUN
bptjm-28	59	30	of	of	ADP
bptjm-28	59	31	medicine	medicine	NOUN
bptjm-28	59	32	|	|	ADP
bptjm-28	59	33	123	123	NUM
bptjm-28	59	34	by	by	ADP
bptjm-28	59	35	samelson	samelson	ADJ
bptjm-28	59	36	-	-	PUNCT
bptjm-28	59	37	jones	jones	PROPN
bptjm-28	59	38	et	et	PROPN
bptjm-28	59	39	.	.	PUNCT
bptjm-28	60	1	al	al	PROPN
bptjm-28	60	2	..	..	PROPN
bptjm-28	61	1	this	this	PRON
bptjm-28	61	2	is	be	AUX
bptjm-28	61	3	again	again	ADV
bptjm-28	61	4	based	base	VERB
bptjm-28	61	5	on	on	ADP
bptjm-28	61	6	the	the	DET
bptjm-28	61	7	potency	potency	NOUN
bptjm-28	61	8	of	of	ADP
bptjm-28	61	9	protein	protein	NOUN
bptjm-28	61	10	factor	factor	NOUN
bptjm-28	61	11	products	product	NOUN
bptjm-28	61	12	and	and	CCONJ
bptjm-28	61	13	monitored	monitor	VERB
bptjm-28	61	14	post	post	ADJ
bptjm-28	61	15	-	-	ADJ
bptjm-28	61	16	infusion	infusion	ADJ
bptjm-28	61	17	processes	process	NOUN
bptjm-28	61	18	.	.	PUNCT
bptjm-28	62	1	additionally	additionally	ADV
bptjm-28	62	2	,	,	PUNCT
bptjm-28	62	3	two	two	NUM
bptjm-28	62	4	methods	method	NOUN
bptjm-28	62	5	to	to	PART
bptjm-28	62	6	test	test	VERB
bptjm-28	62	7	(	(	PUNCT
bptjm-28	62	8	if	if	SCONJ
bptjm-28	62	9	this	this	DET
bptjm-28	62	10	information	information	NOUN
bptjm-28	62	11	is	be	AUX
bptjm-28	62	12	going	go	VERB
bptjm-28	62	13	to	to	PART
bptjm-28	62	14	be	be	AUX
bptjm-28	62	15	included	include	VERB
bptjm-28	62	16	this	this	DET
bptjm-28	62	17	information	information	NOUN
bptjm-28	62	18	,	,	PUNCT
bptjm-28	62	19	it	it	PRON
bptjm-28	62	20	would	would	AUX
bptjm-28	62	21	be	be	AUX
bptjm-28	62	22	helpful	helpful	ADJ
bptjm-28	62	23	to	to	PART
bptjm-28	62	24	elaborate	elaborate	VERB
bptjm-28	62	25	on	on	ADP
bptjm-28	62	26	what	what	PRON
bptjm-28	62	27	these	these	DET
bptjm-28	62	28	tests	test	NOUN
bptjm-28	62	29	look	look	VERB
bptjm-28	62	30	like	like	ADP
bptjm-28	62	31	)	)	PUNCT
bptjm-28	62	32	out	out	ADP
bptjm-28	62	33	this	this	PRON
bptjm-28	62	34	are	be	AUX
bptjm-28	62	35	run	run	VERB
bptjm-28	62	36	through	through	ADP
bptjm-28	62	37	one	one	NUM
bptjm-28	62	38	-	-	PUNCT
bptjm-28	62	39	stage	stage	NOUN
bptjm-28	62	40	clotting	clot	VERB
bptjm-28	62	41	assays	assay	NOUN
bptjm-28	62	42	(	(	PUNCT
bptjm-28	62	43	osas	osa	NOUN
bptjm-28	62	44	)	)	PUNCT
bptjm-28	62	45	or	or	CCONJ
bptjm-28	62	46	chromogenic	chromogenic	ADJ
bptjm-28	62	47	substrate	substrate	NOUN
bptjm-28	62	48	assays	assay	NOUN
bptjm-28	62	49	(	(	PUNCT
bptjm-28	62	50	csas	csa	NOUN
bptjm-28	62	51	)	)	PUNCT
bptjm-28	62	52	which	which	PRON
bptjm-28	62	53	can	can	AUX
bptjm-28	62	54	help	help	VERB
bptjm-28	62	55	de	de	VERB
bptjm-28	62	56	�	�	NOUN
bptjm-28	62	57	ne	ne	PUNCT
bptjm-28	62	58	or	or	CCONJ
bptjm-28	62	59	identify	identify	VERB
bptjm-28	62	60	the	the	DET
bptjm-28	62	61	severity	severity	NOUN
bptjm-28	62	62	of	of	ADP
bptjm-28	62	63	hemophilia	hemophilia	NOUN
bptjm-28	62	64	in	in	ADP
bptjm-28	62	65	the	the	DET
bptjm-28	62	66	patient15	patient15	NOUN
bptjm-28	62	67	.	.	PUNCT
bptjm-28	63	1	lastly	lastly	ADV
bptjm-28	63	2	,	,	PUNCT
bptjm-28	63	3	there	there	PRON
bptjm-28	63	4	are	be	VERB
bptjm-28	63	5	a	a	DET
bptjm-28	63	6	number	number	NOUN
bptjm-28	63	7	of	of	ADP
bptjm-28	63	8	non	non	ADJ
bptjm-28	63	9	-	-	ADJ
bptjm-28	63	10	viral	viral	ADJ
bptjm-28	63	11	ways	way	NOUN
bptjm-28	63	12	to	to	PART
bptjm-28	63	13	transduct	transduct	VERB
bptjm-28	63	14	genes	gene	NOUN
bptjm-28	63	15	.	.	PUNCT
bptjm-28	64	1	some	some	PRON
bptjm-28	64	2	of	of	ADP
bptjm-28	64	3	those	those	DET
bptjm-28	64	4	methods	method	NOUN
bptjm-28	64	5	include	include	VERB
bptjm-28	64	6	electroporation	electroporation	NOUN
bptjm-28	64	7	,	,	PUNCT
bptjm-28	64	8	cationic	cationic	ADJ
bptjm-28	64	9	proteins	protein	NOUN
bptjm-28	64	10	,	,	PUNCT
bptjm-28	64	11	cell	cell	NOUN
bptjm-28	64	12	-	-	PUNCT
bptjm-28	64	13	penetrating	penetrate	VERB
bptjm-28	64	14	peptides	peptide	NOUN
bptjm-28	64	15	,	,	PUNCT
bptjm-28	64	16	nanoparticles	nanoparticle	NOUN
bptjm-28	64	17	,	,	PUNCT
bptjm-28	64	18	crispr	crispr	ADJ
bptjm-28	64	19	editing	editing	NOUN
bptjm-28	64	20	genes	gene	NOUN
bptjm-28	64	21	,	,	PUNCT
bptjm-28	64	22	and	and	CCONJ
bptjm-28	64	23	virus	virus	NOUN
bptjm-28	64	24	-	-	PUNCT
bptjm-28	64	25	like	like	ADJ
bptjm-28	64	26	particles	particle	NOUN
bptjm-28	64	27	(	(	PUNCT
bptjm-28	64	28	vlps)45	vlps)45	NUM
bptjm-28	64	29	.	.	PUNCT
bptjm-28	65	1	iii	iii	X
bptjm-28	65	2	.	.	PUNCT
bptjm-28	65	3	aav	aav	NOUN
bptjm-28	65	4	gene	gene	NOUN
bptjm-28	65	5	therapy	therapy	NOUN
bptjm-28	65	6	the	the	DET
bptjm-28	65	7	most	most	ADV
bptjm-28	65	8	popular	popular	ADJ
bptjm-28	65	9	and	and	CCONJ
bptjm-28	65	10	most	most	ADV
bptjm-28	65	11	successful	successful	ADJ
bptjm-28	65	12	emerging	emerge	VERB
bptjm-28	65	13	therapy	therapy	NOUN
bptjm-28	65	14	to	to	PART
bptjm-28	65	15	treat	treat	VERB
bptjm-28	65	16	hemophilia	hemophilia	NOUN
bptjm-28	65	17	relies	rely	VERB
bptjm-28	65	18	on	on	ADP
bptjm-28	65	19	the	the	DET
bptjm-28	65	20	use	use	NOUN
bptjm-28	65	21	of	of	ADP
bptjm-28	65	22	an	an	DET
bptjm-28	65	23	adeno	adeno	NOUN
bptjm-28	65	24	-	-	PUNCT
bptjm-28	65	25	associated	associate	VERB
bptjm-28	65	26	viral	viral	ADJ
bptjm-28	65	27	vector	vector	NOUN
bptjm-28	65	28	(	(	PUNCT
bptjm-28	65	29	aav	aav	PROPN
bptjm-28	65	30	)	)	PUNCT
bptjm-28	65	31	as	as	ADP
bptjm-28	65	32	a	a	DET
bptjm-28	65	33	vehicle	vehicle	NOUN
bptjm-28	65	34	for	for	ADP
bptjm-28	65	35	gene	gene	NOUN
bptjm-28	65	36	delivery	delivery	NOUN
bptjm-28	65	37	of	of	ADP
bptjm-28	65	38	factor	factor	NOUN
bptjm-28	65	39	viii	viii	NOUN
bptjm-28	65	40	and	and	CCONJ
bptjm-28	65	41	ix	ix	PROPN
bptjm-28	65	42	.	.	PUNCT
bptjm-28	66	1	aav	aav	NOUN
bptjm-28	66	2	-	-	PUNCT
bptjm-28	66	3	gene	gene	NOUN
bptjm-28	66	4	therapy	therapy	NOUN
bptjm-28	66	5	is	be	AUX
bptjm-28	66	6	popular	popular	ADJ
bptjm-28	66	7	due	due	ADP
bptjm-28	66	8	to	to	ADP
bptjm-28	66	9	its	its	PRON
bptjm-28	66	10	e	e	PROPN
bptjm-28	66	11	�	�	NOUN
bptjm-28	66	12	cacy	cacy	NOUN
bptjm-28	66	13	,	,	PUNCT
bptjm-28	66	14	relatively	relatively	ADV
bptjm-28	66	15	low	low	ADJ
bptjm-28	66	16	invasiveness	invasiveness	ADJ
bptjm-28	66	17	,	,	PUNCT
bptjm-28	66	18	minor	minor	ADJ
bptjm-28	66	19	side	side	NOUN
bptjm-28	66	20	e	e	NOUN
bptjm-28	66	21	�	�	NOUN
bptjm-28	66	22	ects	ect	VERB
bptjm-28	66	23	in	in	ADP
bptjm-28	66	24	animal	animal	NOUN
bptjm-28	66	25	models	model	NOUN
bptjm-28	66	26	,	,	PUNCT
bptjm-28	66	27	and	and	CCONJ
bptjm-28	66	28	its	its	PRON
bptjm-28	66	29	ability	ability	NOUN
bptjm-28	66	30	to	to	PART
bptjm-28	66	31	provide	provide	VERB
bptjm-28	66	32	long	long	ADV
bptjm-28	66	33	-	-	PUNCT
bptjm-28	66	34	lasting	last	VERB
bptjm-28	66	35	expression	expression	NOUN
bptjm-28	66	36	of	of	ADP
bptjm-28	66	37	factor	factor	NOUN
bptjm-28	66	38	viii	viii	NOUN
bptjm-28	66	39	and	and	CCONJ
bptjm-28	66	40	ix	ix	PROPN
bptjm-28	66	41	.	.	PUNCT
bptjm-28	67	1	despite	despite	SCONJ
bptjm-28	67	2	these	these	DET
bptjm-28	67	3	advantages	advantage	NOUN
bptjm-28	67	4	,	,	PUNCT
bptjm-28	67	5	however	however	ADV
bptjm-28	67	6	,	,	PUNCT
bptjm-28	67	7	the	the	DET
bptjm-28	67	8	presence	presence	NOUN
bptjm-28	67	9	of	of	ADP
bptjm-28	67	10	neutralizing	neutralize	VERB
bptjm-28	67	11	antibodies	antibody	NOUN
bptjm-28	67	12	from	from	ADP
bptjm-28	67	13	previous	previous	ADJ
bptjm-28	67	14	exposure	exposure	NOUN
bptjm-28	67	15	to	to	ADP
bptjm-28	67	16	aav	aav	NOUN
bptjm-28	67	17	remains	remain	VERB
bptjm-28	67	18	a	a	DET
bptjm-28	67	19	challenge	challenge	NOUN
bptjm-28	67	20	that	that	PRON
bptjm-28	67	21	obstructs	obstruct	VERB
bptjm-28	67	22	this	this	DET
bptjm-28	67	23	therapy	therapy	NOUN
bptjm-28	67	24	from	from	ADP
bptjm-28	67	25	being	be	AUX
bptjm-28	67	26	widely	widely	ADV
bptjm-28	67	27	accepted	accept	VERB
bptjm-28	67	28	.	.	PUNCT
bptjm-28	68	1	with	with	ADP
bptjm-28	68	2	minor	minor	ADJ
bptjm-28	68	3	concerns	concern	NOUN
bptjm-28	68	4	over	over	ADP
bptjm-28	68	5	inhibitor	inhibitor	NOUN
bptjm-28	68	6	development	development	NOUN
bptjm-28	68	7	,	,	PUNCT
bptjm-28	68	8	aav	aav	NOUN
bptjm-28	68	9	-	-	PUNCT
bptjm-28	68	10	gene	gene	NOUN
bptjm-28	68	11	therapy	therapy	NOUN
bptjm-28	68	12	is	be	AUX
bptjm-28	68	13	proving	prove	VERB
bptjm-28	68	14	to	to	PART
bptjm-28	68	15	be	be	AUX
bptjm-28	68	16	a	a	DET
bptjm-28	68	17	potential	potential	ADJ
bptjm-28	68	18	treatment	treatment	NOUN
bptjm-28	68	19	for	for	ADP
bptjm-28	68	20	hemophilia	hemophilia	NOUN
bptjm-28	68	21	patients	patient	NOUN
bptjm-28	68	22	.	.	PUNCT
bptjm-28	69	1	aav	aav	NOUN
bptjm-28	69	2	vector	vector	NOUN
bptjm-28	69	3	advantages	advantage	NOUN
bptjm-28	69	4	and	and	CCONJ
bptjm-28	69	5	uses	use	VERB
bptjm-28	69	6	a	a	DET
bptjm-28	69	7	particular	particular	ADJ
bptjm-28	69	8	gene	gene	NOUN
bptjm-28	69	9	therapy	therapy	NOUN
bptjm-28	69	10	that	that	PRON
bptjm-28	69	11	is	be	AUX
bptjm-28	69	12	a	a	DET
bptjm-28	69	13	gene	gene	NOUN
bptjm-28	69	14	therapy	therapy	NOUN
bptjm-28	69	15	model	model	NOUN
bptjm-28	69	16	that	that	PRON
bptjm-28	69	17	is	be	AUX
bptjm-28	69	18	being	be	AUX
bptjm-28	69	19	explored	explore	VERB
bptjm-28	69	20	right	right	ADV
bptjm-28	69	21	now	now	ADV
bptjm-28	69	22	and	and	CCONJ
bptjm-28	69	23	very	very	ADV
bptjm-28	69	24	successful	successful	ADJ
bptjm-28	69	25	in	in	ADP
bptjm-28	69	26	various	various	ADJ
bptjm-28	69	27	clinical	clinical	ADJ
bptjm-28	69	28	trials	trial	NOUN
bptjm-28	69	29	.	.	PUNCT
bptjm-28	70	1	adeno	adeno	NOUN
bptjm-28	70	2	-	-	PUNCT
bptjm-28	70	3	associated	associate	VERB
bptjm-28	70	4	virus	virus	NOUN
bptjm-28	70	5	(	(	PUNCT
bptjm-28	70	6	aav	aav	NOUN
bptjm-28	70	7	)	)	PUNCT
bptjm-28	70	8	vector	vector	NOUN
bptjm-28	70	9	is	be	AUX
bptjm-28	70	10	a	a	DET
bptjm-28	70	11	new	new	ADJ
bptjm-28	70	12	technology	technology	NOUN
bptjm-28	70	13	that	that	PRON
bptjm-28	70	14	is	be	AUX
bptjm-28	70	15	emerging	emerge	VERB
bptjm-28	70	16	into	into	ADP
bptjm-28	70	17	the	the	DET
bptjm-28	70	18	scienti	scienti	NOUN
bptjm-28	70	19	�	�	PROPN
bptjm-28	70	20	c	c	PROPN
bptjm-28	70	21	community	community	NOUN
bptjm-28	70	22	as	as	ADP
bptjm-28	70	23	an	an	DET
bptjm-28	70	24	e	e	NOUN
bptjm-28	70	25	�	�	NOUN
bptjm-28	70	26	ective	ective	ADJ
bptjm-28	70	27	method	method	NOUN
bptjm-28	70	28	to	to	PART
bptjm-28	70	29	amend	amend	VERB
bptjm-28	70	30	the	the	DET
bptjm-28	70	31	existing	exist	VERB
bptjm-28	70	32	molecular	molecular	ADJ
bptjm-28	70	33	dna	dna	NOUN
bptjm-28	70	34	sequence	sequence	NOUN
bptjm-28	70	35	of	of	ADP
bptjm-28	70	36	cells	cell	NOUN
bptjm-28	70	37	,	,	PUNCT
bptjm-28	70	38	without	without	ADP
bptjm-28	70	39	incorporating	incorporate	VERB
bptjm-28	70	40	the	the	DET
bptjm-28	70	41	virus	virus	NOUN
bptjm-28	70	42	’s	’s	PART
bptjm-28	70	43	dna	dna	NOUN
bptjm-28	70	44	into	into	ADP
bptjm-28	70	45	the	the	DET
bptjm-28	70	46	host	host	NOUN
bptjm-28	70	47	’s	’s	PART
bptjm-28	70	48	dna	dna	PROPN
bptjm-28	70	49	sequence16	sequence16	PROPN
bptjm-28	70	50	.	.	PUNCT
bptjm-28	71	1	there	there	PRON
bptjm-28	71	2	are	be	VERB
bptjm-28	71	3	many	many	ADJ
bptjm-28	71	4	advantages	advantage	NOUN
bptjm-28	71	5	to	to	ADP
bptjm-28	71	6	aav	aav	NOUN
bptjm-28	71	7	which	which	PRON
bptjm-28	71	8	are	be	AUX
bptjm-28	71	9	used	use	VERB
bptjm-28	71	10	for	for	ADP
bptjm-28	71	11	a	a	DET
bptjm-28	71	12	plethora	plethora	NOUN
bptjm-28	71	13	of	of	ADP
bptjm-28	71	14	diseases	disease	NOUN
bptjm-28	71	15	within	within	ADP
bptjm-28	71	16	the	the	DET
bptjm-28	71	17	body	body	NOUN
bptjm-28	71	18	including	include	VERB
bptjm-28	71	19	neurodegenerative	neurodegenerative	ADJ
bptjm-28	71	20	diseases	disease	NOUN
bptjm-28	71	21	,	,	PUNCT
bptjm-28	71	22	cancer	cancer	NOUN
bptjm-28	71	23	,	,	PUNCT
bptjm-28	71	24	and	and	CCONJ
bptjm-28	71	25	genetic	genetic	ADJ
bptjm-28	71	26	diseases	disease	NOUN
bptjm-28	71	27	as	as	ADP
bptjm-28	71	28	a	a	DET
bptjm-28	71	29	whole	whole	NOUN
bptjm-28	71	30	.	.	PUNCT
bptjm-28	72	1	this	this	DET
bptjm-28	72	2	gene	gene	NOUN
bptjm-28	72	3	therapy	therapy	NOUN
bptjm-28	72	4	model	model	NOUN
bptjm-28	72	5	is	be	AUX
bptjm-28	72	6	being	be	AUX
bptjm-28	72	7	explored	explore	VERB
bptjm-28	72	8	currently	currently	ADV
bptjm-28	72	9	in	in	ADP
bptjm-28	72	10	various	various	ADJ
bptjm-28	72	11	methods	method	NOUN
bptjm-28	72	12	and	and	CCONJ
bptjm-28	72	13	research	research	NOUN
bptjm-28	72	14	papers	paper	NOUN
bptjm-28	72	15	to	to	PART
bptjm-28	72	16	observe	observe	VERB
bptjm-28	72	17	new	new	ADJ
bptjm-28	72	18	berkeley	berkeley	PROPN
bptjm-28	72	19	pharma	pharma	PROPN
bptjm-28	72	20	tech	tech	NOUN
bptjm-28	72	21	journal	journal	NOUN
bptjm-28	72	22	of	of	ADP
bptjm-28	72	23	medicine	medicine	NOUN
bptjm-28	72	24	|	|	ADV
bptjm-28	72	25	124	124	NUM
bptjm-28	72	26	dna	dna	PROPN
bptjm-28	72	27	appending	append	VERB
bptjm-28	72	28	techniques17	techniques17	ADV
bptjm-28	72	29	.	.	PUNCT
bptjm-28	73	1	this	this	DET
bptjm-28	73	2	gene	gene	NOUN
bptjm-28	73	3	therapy	therapy	NOUN
bptjm-28	73	4	is	be	AUX
bptjm-28	73	5	nonpathogenic	nonpathogenic	ADJ
bptjm-28	73	6	and	and	CCONJ
bptjm-28	73	7	has	have	VERB
bptjm-28	73	8	many	many	ADJ
bptjm-28	73	9	uses	use	NOUN
bptjm-28	73	10	to	to	PART
bptjm-28	73	11	express	express	VERB
bptjm-28	73	12	genes	gene	NOUN
bptjm-28	73	13	of	of	ADP
bptjm-28	73	14	interest	interest	NOUN
bptjm-28	73	15	.	.	PUNCT
bptjm-28	74	1	additionally	additionally	ADV
bptjm-28	74	2	,	,	PUNCT
bptjm-28	74	3	there	there	PRON
bptjm-28	74	4	are	be	VERB
bptjm-28	74	5	new	new	ADJ
bptjm-28	74	6	genetic	genetic	ADJ
bptjm-28	74	7	sequencing	sequence	VERB
bptjm-28	74	8	methods	method	NOUN
bptjm-28	74	9	that	that	PRON
bptjm-28	74	10	allow	allow	VERB
bptjm-28	74	11	for	for	ADP
bptjm-28	74	12	the	the	DET
bptjm-28	74	13	design	design	NOUN
bptjm-28	74	14	of	of	ADP
bptjm-28	74	15	vectors	vector	NOUN
bptjm-28	74	16	/	/	SYM
bptjm-28	74	17	plasmids	plasmid	NOUN
bptjm-28	74	18	and	and	CCONJ
bptjm-28	74	19	target	target	VERB
bptjm-28	74	20	speci	speci	PROPN
bptjm-28	74	21	�	�	PROPN
bptjm-28	74	22	c	c	NOUN
bptjm-28	74	23	parts	part	NOUN
bptjm-28	74	24	of	of	ADP
bptjm-28	74	25	the	the	DET
bptjm-28	74	26	body	body	NOUN
bptjm-28	74	27	.	.	PUNCT
bptjm-28	75	1	because	because	SCONJ
bptjm-28	75	2	of	of	ADP
bptjm-28	75	3	its	its	PRON
bptjm-28	75	4	great	great	ADJ
bptjm-28	75	5	amendable	amendable	ADJ
bptjm-28	75	6	characteristics	characteristic	NOUN
bptjm-28	75	7	to	to	ADP
bptjm-28	75	8	genetic	genetic	ADJ
bptjm-28	75	9	engineering	engineering	NOUN
bptjm-28	75	10	and	and	CCONJ
bptjm-28	75	11	repurposing	repurposing	NOUN
bptjm-28	75	12	makes	make	VERB
bptjm-28	75	13	it	it	PRON
bptjm-28	75	14	easy	easy	ADJ
bptjm-28	75	15	to	to	PART
bptjm-28	75	16	design	design	VERB
bptjm-28	75	17	relative	relative	ADJ
bptjm-28	75	18	to	to	ADP
bptjm-28	75	19	previous	previous	ADJ
bptjm-28	75	20	gene	gene	NOUN
bptjm-28	75	21	therapy	therapy	NOUN
bptjm-28	75	22	techniques	technique	NOUN
bptjm-28	75	23	suggested	suggest	VERB
bptjm-28	75	24	by	by	ADP
bptjm-28	75	25	a	a	DET
bptjm-28	75	26	review	review	NOUN
bptjm-28	75	27	by	by	ADP
bptjm-28	75	28	andari	andari	PROPN
bptjm-28	75	29	et	et	PROPN
bptjm-28	75	30	.	.	PUNCT
bptjm-28	76	1	al.18	al.18	PROPN
bptjm-28	76	2	.	.	PUNCT
bptjm-28	77	1	this	this	PRON
bptjm-28	77	2	not	not	PART
bptjm-28	77	3	only	only	ADV
bptjm-28	77	4	makes	make	VERB
bptjm-28	77	5	it	it	PRON
bptjm-28	77	6	easy	easy	ADJ
bptjm-28	77	7	to	to	PART
bptjm-28	77	8	design	design	VERB
bptjm-28	77	9	but	but	CCONJ
bptjm-28	77	10	increases	increase	VERB
bptjm-28	77	11	the	the	DET
bptjm-28	77	12	cell	cell	NOUN
bptjm-28	77	13	speci	speci	NOUN
bptjm-28	77	14	�	�	PROPN
bptjm-28	77	15	city	city	NOUN
bptjm-28	77	16	,	,	PUNCT
bptjm-28	77	17	cell	cell	NOUN
bptjm-28	77	18	or	or	CCONJ
bptjm-28	77	19	organ	organ	NOUN
bptjm-28	77	20	targeting	targeting	NOUN
bptjm-28	77	21	,	,	PUNCT
bptjm-28	77	22	and	and	CCONJ
bptjm-28	77	23	transduction	transduction	NOUN
bptjm-28	77	24	e	e	NOUN
bptjm-28	77	25	�	�	NOUN
bptjm-28	77	26	ciency	ciency	NOUN
bptjm-28	77	27	.	.	PUNCT
bptjm-28	78	1	aav	aav	NOUN
bptjm-28	78	2	has	have	AUX
bptjm-28	78	3	shown	show	VERB
bptjm-28	78	4	to	to	PART
bptjm-28	78	5	be	be	AUX
bptjm-28	78	6	non	non	ADJ
bptjm-28	78	7	-	-	ADJ
bptjm-28	78	8	pathogenic	pathogenic	ADJ
bptjm-28	78	9	and	and	CCONJ
bptjm-28	78	10	induces	induce	VERB
bptjm-28	78	11	a	a	DET
bptjm-28	78	12	minimal	minimal	ADJ
bptjm-28	78	13	in	in	ADP
bptjm-28	78	14	�	�	NOUN
bptjm-28	78	15	ammatory	ammatory	ADJ
bptjm-28	78	16	response	response	NOUN
bptjm-28	78	17	in	in	ADP
bptjm-28	78	18	mouse	mouse	NOUN
bptjm-28	78	19	models	model	NOUN
bptjm-28	78	20	and	and	CCONJ
bptjm-28	78	21	early	early	ADJ
bptjm-28	78	22	human	human	ADJ
bptjm-28	78	23	clinical	clinical	ADJ
bptjm-28	78	24	trials	trial	NOUN
bptjm-28	78	25	.	.	PUNCT
bptjm-28	79	1	furthermore	furthermore	ADV
bptjm-28	79	2	,	,	PUNCT
bptjm-28	79	3	aav	aav	NOUN
bptjm-28	79	4	has	have	VERB
bptjm-28	79	5	fewer	few	ADJ
bptjm-28	79	6	biosafety	biosafety	NOUN
bptjm-28	79	7	hazards	hazard	NOUN
bptjm-28	79	8	,	,	PUNCT
bptjm-28	79	9	unlike	unlike	ADP
bptjm-28	79	10	other	other	ADJ
bptjm-28	79	11	gene	gene	NOUN
bptjm-28	79	12	therapies	therapy	NOUN
bptjm-28	79	13	suggested	suggest	VERB
bptjm-28	79	14	by	by	ADP
bptjm-28	79	15	a	a	DET
bptjm-28	79	16	review	review	NOUN
bptjm-28	79	17	by	by	ADP
bptjm-28	79	18	aschauer	aschauer	NOUN
bptjm-28	79	19	et.al	et.al	PROPN
bptjm-28	79	20	.	.	PUNCT
bptjm-28	79	21	,	,	PUNCT
bptjm-28	79	22	while	while	SCONJ
bptjm-28	79	23	having	have	VERB
bptjm-28	79	24	a	a	DET
bptjm-28	79	25	low	low	ADJ
bptjm-28	79	26	immunogenicity	immunogenicity	NOUN
bptjm-28	79	27	and	and	CCONJ
bptjm-28	79	28	limiting	limit	VERB
bptjm-28	79	29	the	the	DET
bptjm-28	79	30	risk	risk	NOUN
bptjm-28	79	31	of	of	ADP
bptjm-28	79	32	insertional	insertional	ADJ
bptjm-28	79	33	mutagenesis	mutagenesis	NOUN
bptjm-28	79	34	or	or	CCONJ
bptjm-28	79	35	other	other	ADJ
bptjm-28	79	36	mutational	mutational	ADJ
bptjm-28	79	37	changes	change	NOUN
bptjm-28	79	38	when	when	SCONJ
bptjm-28	79	39	replicating17	replicating17	ADJ
bptjm-28	79	40	.	.	PUNCT
bptjm-28	80	1	figure	figure	VERB
bptjm-28	80	2	1	1	NUM
bptjm-28	80	3	:	:	PUNCT
bptjm-28	80	4	structure	structure	NOUN
bptjm-28	80	5	of	of	ADP
bptjm-28	80	6	an	an	DET
bptjm-28	80	7	aav	aav	NOUN
bptjm-28	80	8	vector	vector	NOUN
bptjm-28	80	9	.	.	PUNCT
bptjm-28	81	1	goi	goi	PROPN
bptjm-28	81	2	,	,	PUNCT
bptjm-28	81	3	the	the	DET
bptjm-28	81	4	gene	gene	NOUN
bptjm-28	81	5	of	of	ADP
bptjm-28	81	6	interest	interest	NOUN
bptjm-28	81	7	,	,	PUNCT
bptjm-28	81	8	target	target	NOUN
bptjm-28	81	9	sequence	sequence	NOUN
bptjm-28	81	10	that	that	PRON
bptjm-28	81	11	is	be	AUX
bptjm-28	81	12	to	to	PART
bptjm-28	81	13	be	be	AUX
bptjm-28	81	14	inserted	insert	VERB
bptjm-28	81	15	into	into	ADP
bptjm-28	81	16	the	the	DET
bptjm-28	81	17	vector	vector	NOUN
bptjm-28	81	18	.	.	PUNCT
bptjm-28	82	1	other	other	ADJ
bptjm-28	82	2	gene	gene	NOUN
bptjm-28	82	3	therapies	therapy	NOUN
bptjm-28	82	4	focused	focus	VERB
bptjm-28	82	5	on	on	ADP
bptjm-28	82	6	providing	provide	VERB
bptjm-28	82	7	the	the	DET
bptjm-28	82	8	proteins	protein	NOUN
bptjm-28	82	9	necessary	necessary	ADJ
bptjm-28	82	10	for	for	ADP
bptjm-28	82	11	transduction	transduction	NOUN
bptjm-28	82	12	while	while	SCONJ
bptjm-28	82	13	we	we	PRON
bptjm-28	82	14	wanted	want	VERB
bptjm-28	82	15	to	to	PART
bptjm-28	82	16	focus	focus	VERB
bptjm-28	82	17	on	on	ADP
bptjm-28	82	18	the	the	DET
bptjm-28	82	19	core	core	NOUN
bptjm-28	82	20	protein	protein	NOUN
bptjm-28	82	21	that	that	PRON
bptjm-28	82	22	is	be	AUX
bptjm-28	82	23	stopping	stop	VERB
bptjm-28	82	24	transduction	transduction	NOUN
bptjm-28	82	25	and	and	CCONJ
bptjm-28	82	26	see	see	VERB
bptjm-28	82	27	what	what	PRON
bptjm-28	82	28	was	be	AUX
bptjm-28	82	29	lacking	lack	VERB
bptjm-28	82	30	in	in	ADP
bptjm-28	82	31	the	the	DET
bptjm-28	82	32	pathway	pathway	NOUN
bptjm-28	82	33	.	.	PUNCT
bptjm-28	83	1	the	the	DET
bptjm-28	83	2	coagulation	coagulation	NOUN
bptjm-28	83	3	cascade	cascade	NOUN
bptjm-28	83	4	is	be	AUX
bptjm-28	83	5	a	a	DET
bptjm-28	83	6	concept	concept	NOUN
bptjm-28	83	7	that	that	PRON
bptjm-28	83	8	is	be	AUX
bptjm-28	83	9	still	still	ADV
bptjm-28	83	10	being	be	AUX
bptjm-28	83	11	explored	explore	VERB
bptjm-28	83	12	as	as	SCONJ
bptjm-28	83	13	many	many	ADJ
bptjm-28	83	14	elements	element	NOUN
bptjm-28	83	15	play	play	VERB
bptjm-28	83	16	a	a	DET
bptjm-28	83	17	role	role	NOUN
bptjm-28	83	18	in	in	ADP
bptjm-28	83	19	the	the	DET
bptjm-28	83	20	triggering	trigger	VERB
bptjm-28	83	21	events	event	NOUN
bptjm-28	83	22	.	.	PUNCT
bptjm-28	84	1	a	a	DET
bptjm-28	84	2	general	general	ADJ
bptjm-28	84	3	outlook	outlook	NOUN
bptjm-28	84	4	on	on	ADP
bptjm-28	84	5	the	the	DET
bptjm-28	84	6	cascade	cascade	NOUN
bptjm-28	84	7	is	be	AUX
bptjm-28	84	8	started	start	VERB
bptjm-28	84	9	with	with	ADP
bptjm-28	84	10	a	a	DET
bptjm-28	84	11	stimulus	stimulus	NOUN
bptjm-28	84	12	from	from	ADP
bptjm-28	84	13	the	the	DET
bptjm-28	84	14	external	external	ADJ
bptjm-28	84	15	environment	environment	NOUN
bptjm-28	84	16	such	such	ADJ
bptjm-28	84	17	as	as	ADP
bptjm-28	84	18	a	a	DET
bptjm-28	84	19	cut	cut	NOUN
bptjm-28	84	20	or	or	CCONJ
bptjm-28	84	21	broken	break	VERB
bptjm-28	84	22	tissue	tissue	NOUN
bptjm-28	84	23	increasing	increase	VERB
bptjm-28	84	24	the	the	DET
bptjm-28	84	25	amount	amount	NOUN
bptjm-28	84	26	of	of	ADP
bptjm-28	84	27	the	the	DET
bptjm-28	84	28	protein	protein	NOUN
bptjm-28	84	29	thrombin	thrombin	NOUN
bptjm-28	84	30	to	to	PART
bptjm-28	84	31	form	form	VERB
bptjm-28	84	32	the	the	DET
bptjm-28	84	33	extrinsic	extrinsic	ADJ
bptjm-28	84	34	pathway	pathway	NOUN
bptjm-28	84	35	.	.	PUNCT
bptjm-28	85	1	a	a	DET
bptjm-28	85	2	set	set	NOUN
bptjm-28	85	3	of	of	ADP
bptjm-28	85	4	triggering	trigger	VERB
bptjm-28	85	5	events	event	NOUN
bptjm-28	85	6	will	will	AUX
bptjm-28	85	7	then	then	ADV
bptjm-28	85	8	increase	increase	VERB
bptjm-28	85	9	the	the	DET
bptjm-28	85	10	von	von	PROPN
bptjm-28	85	11	willebrand	willebrand	NOUN
bptjm-28	85	12	factor	factor	NOUN
bptjm-28	85	13	and	and	CCONJ
bptjm-28	85	14	factor	factor	NOUN
bptjm-28	85	15	viii	viii	NOUN
bptjm-28	85	16	to	to	PART
bptjm-28	85	17	interact	interact	VERB
bptjm-28	85	18	with	with	ADP
bptjm-28	85	19	factor	factor	NOUN
bptjm-28	85	20	ix	ix	PROPN
bptjm-28	85	21	.	.	PUNCT
bptjm-28	86	1	factor	factor	NOUN
bptjm-28	86	2	viii	viii	NOUN
bptjm-28	86	3	and	and	CCONJ
bptjm-28	86	4	ix	ix	NOUN
bptjm-28	86	5	are	be	AUX
bptjm-28	86	6	the	the	DET
bptjm-28	86	7	main	main	ADJ
bptjm-28	86	8	factors	factor	NOUN
bptjm-28	86	9	necessary	necessary	ADJ
bptjm-28	86	10	for	for	ADP
bptjm-28	86	11	transduction	transduction	NOUN
bptjm-28	86	12	which	which	PRON
bptjm-28	86	13	will	will	AUX
bptjm-28	86	14	trigger	trigger	VERB
bptjm-28	86	15	factor	factor	NOUN
bptjm-28	86	16	10	10	NUM
bptjm-28	86	17	to	to	PART
bptjm-28	86	18	convert	convert	VERB
bptjm-28	86	19	prothrombin	prothrombin	NOUN
bptjm-28	86	20	to	to	ADP
bptjm-28	86	21	thrombin	thrombin	NOUN
bptjm-28	86	22	.	.	PUNCT
bptjm-28	87	1	thrombin	thrombin	NOUN
bptjm-28	87	2	activates	activate	VERB
bptjm-28	87	3	factors	factor	NOUN
bptjm-28	87	4	v	v	ADP
bptjm-28	87	5	,	,	PUNCT
bptjm-28	87	6	viii	viii	ADJ
bptjm-28	87	7	,	,	PUNCT
bptjm-28	87	8	ix	ix	PROPN
bptjm-28	87	9	berkeley	berkeley	PROPN
bptjm-28	87	10	pharma	pharma	PROPN
bptjm-28	87	11	tech	tech	NOUN
bptjm-28	87	12	journal	journal	NOUN
bptjm-28	87	13	of	of	ADP
bptjm-28	87	14	medicine	medicine	NOUN
bptjm-28	87	15	|	|	ADV
bptjm-28	87	16	125	125	NUM
bptjm-28	87	17	and	and	CCONJ
bptjm-28	87	18	xi	xi	NUM
bptjm-28	87	19	,	,	PUNCT
bptjm-28	87	20	to	to	PART
bptjm-28	87	21	promote	promote	VERB
bptjm-28	87	22	its	its	PRON
bptjm-28	87	23	own	own	ADJ
bptjm-28	87	24	generation	generation	NOUN
bptjm-28	87	25	.	.	PUNCT
bptjm-28	88	1	thrombin	thrombin	NOUN
bptjm-28	88	2	then	then	ADV
bptjm-28	88	3	will	will	AUX
bptjm-28	88	4	then	then	ADV
bptjm-28	88	5	activate	activate	VERB
bptjm-28	88	6	soluble	soluble	ADJ
bptjm-28	88	7	�	�	NOUN
bptjm-28	88	8	brinogen	brinogen	PROPN
bptjm-28	88	9	to	to	PART
bptjm-28	88	10	convert	convert	VERB
bptjm-28	88	11	into	into	ADP
bptjm-28	88	12	an	an	DET
bptjm-28	88	13	insoluble	insoluble	ADJ
bptjm-28	88	14	version	version	NOUN
bptjm-28	88	15	of	of	ADP
bptjm-28	88	16	itself	itself	PRON
bptjm-28	88	17	called	call	VERB
bptjm-28	88	18	�	�	PROPN
bptjm-28	88	19	brin	brin	PROPN
bptjm-28	88	20	to	to	PART
bptjm-28	88	21	make	make	VERB
bptjm-28	88	22	the	the	DET
bptjm-28	88	23	webbing	webbing	NOUN
bptjm-28	88	24	of	of	ADP
bptjm-28	88	25	the	the	DET
bptjm-28	88	26	blood	blood	NOUN
bptjm-28	88	27	clot	clot	NOUN
bptjm-28	88	28	in	in	ADP
bptjm-28	88	29	the	the	DET
bptjm-28	88	30	location	location	NOUN
bptjm-28	88	31	of	of	ADP
bptjm-28	88	32	the	the	DET
bptjm-28	88	33	cut	cut	NOUN
bptjm-28	88	34	or	or	CCONJ
bptjm-28	88	35	tissue	tissue	NOUN
bptjm-28	88	36	breakage	breakage	NOUN
bptjm-28	88	37	.	.	PUNCT
bptjm-28	89	1	there	there	PRON
bptjm-28	89	2	is	be	VERB
bptjm-28	89	3	a	a	DET
bptjm-28	89	4	plethora	plethora	NOUN
bptjm-28	89	5	of	of	ADP
bptjm-28	89	6	gene	gene	NOUN
bptjm-28	89	7	therapy	therapy	NOUN
bptjm-28	89	8	methods	method	NOUN
bptjm-28	89	9	explored	explore	VERB
bptjm-28	89	10	that	that	DET
bptjm-28	89	11	focus	focus	NOUN
bptjm-28	89	12	on	on	ADP
bptjm-28	89	13	providing	provide	VERB
bptjm-28	89	14	the	the	DET
bptjm-28	89	15	proteins	protein	NOUN
bptjm-28	89	16	necessary	necessary	ADJ
bptjm-28	89	17	for	for	ADP
bptjm-28	89	18	transduction	transduction	NOUN
bptjm-28	89	19	,	,	PUNCT
bptjm-28	89	20	and	and	CCONJ
bptjm-28	89	21	the	the	DET
bptjm-28	89	22	main	main	ADJ
bptjm-28	89	23	protein	protein	NOUN
bptjm-28	89	24	factors	factor	NOUN
bptjm-28	89	25	being	be	AUX
bptjm-28	89	26	factors	factor	NOUN
bptjm-28	89	27	viii	viii	ADJ
bptjm-28	89	28	and	and	CCONJ
bptjm-28	90	1	ix	ix	PROPN
bptjm-28	90	2	.	.	PUNCT
bptjm-28	91	1	aav	aav	PROPN
bptjm-28	91	2	gene	gene	NOUN
bptjm-28	91	3	therapy	therapy	NOUN
bptjm-28	91	4	focuses	focus	VERB
bptjm-28	91	5	on	on	ADP
bptjm-28	91	6	promoting	promote	VERB
bptjm-28	91	7	factors	factor	NOUN
bptjm-28	91	8	viii	viii	ADJ
bptjm-28	91	9	and	and	CCONJ
bptjm-28	91	10	ix	ix	ADP
bptjm-28	91	11	which	which	PRON
bptjm-28	91	12	stop	stop	VERB
bptjm-28	91	13	transduction	transduction	NOUN
bptjm-28	91	14	and	and	CCONJ
bptjm-28	91	15	make	make	VERB
bptjm-28	91	16	up	up	ADP
bptjm-28	91	17	hemophilia19	hemophilia19	NOUN
bptjm-28	91	18	,	,	PUNCT
bptjm-28	91	19	20	20	NUM
bptjm-28	91	20	.	.	PUNCT
bptjm-28	92	1	figure	figure	NOUN
bptjm-28	92	2	2	2	NUM
bptjm-28	92	3	:	:	PUNCT
bptjm-28	92	4	blood	blood	NOUN
bptjm-28	92	5	coagulation	coagulation	NOUN
bptjm-28	92	6	cascades	cascade	VERB
bptjm-28	92	7	-the	-the	DET
bptjm-28	92	8	intrinsic	intrinsic	ADJ
bptjm-28	92	9	and	and	CCONJ
bptjm-28	92	10	extrinsic	extrinsic	ADJ
bptjm-28	92	11	pathways	pathway	NOUN
bptjm-28	92	12	.	.	PUNCT
bptjm-28	93	1	by	by	ADP
bptjm-28	93	2	joe	joe	PROPN
bptjm-28	93	3	d	d	PROPN
bptjm-28	93	4	own	own	ADJ
bptjm-28	93	5	work	work	NOUN
bptjm-28	93	6	,	,	PUNCT
bptjm-28	93	7	cc	cc	VERB
bptjm-28	93	8	by	by	ADP
bptjm-28	93	9	-	-	PUNCT
bptjm-28	93	10	sa	sa	PROPN
bptjm-28	93	11	3.0	3.0	NUM
bptjm-28	93	12	,	,	PUNCT
bptjm-28	93	13	https://commons.wikimedia.org/w/index.php?curid=1983833	https://commons.wikimedia.org/w/index.php?curid=1983833	ADP
bptjm-28	93	14	vector	vector	NOUN
bptjm-28	93	15	and	and	CCONJ
bptjm-28	93	16	plasmid	plasmid	NOUN
bptjm-28	93	17	design	design	NOUN
bptjm-28	93	18	from	from	ADP
bptjm-28	93	19	various	various	ADJ
bptjm-28	93	20	clinical	clinical	ADJ
bptjm-28	93	21	trials	trial	NOUN
bptjm-28	93	22	,	,	PUNCT
bptjm-28	93	23	we	we	PRON
bptjm-28	93	24	will	will	AUX
bptjm-28	93	25	compose	compose	VERB
bptjm-28	93	26	a	a	DET
bptjm-28	93	27	collection	collection	NOUN
bptjm-28	93	28	of	of	ADP
bptjm-28	93	29	e	e	PROPN
bptjm-28	93	30	�	�	PROPN
bptjm-28	93	31	ective	ective	ADJ
bptjm-28	93	32	aav	aav	NOUN
bptjm-28	93	33	vectors	vector	NOUN
bptjm-28	93	34	that	that	PRON
bptjm-28	93	35	can	can	AUX
bptjm-28	93	36	transduce	transduce	VERB
bptjm-28	93	37	the	the	DET
bptjm-28	93	38	factors	factor	NOUN
bptjm-28	93	39	8/9	8/9	NUM
bptjm-28	93	40	into	into	ADP
bptjm-28	93	41	the	the	DET
bptjm-28	93	42	hepatocytes	hepatocyte	NOUN
bptjm-28	93	43	.	.	PUNCT
bptjm-28	94	1	aav	aav	NOUN
bptjm-28	94	2	is	be	AUX
bptjm-28	94	3	a	a	DET
bptjm-28	94	4	very	very	ADV
bptjm-28	94	5	broad	broad	ADJ
bptjm-28	94	6	type	type	NOUN
bptjm-28	94	7	of	of	ADP
bptjm-28	94	8	vector	vector	NOUN
bptjm-28	94	9	that	that	PRON
bptjm-28	94	10	has	have	VERB
bptjm-28	94	11	many	many	ADJ
bptjm-28	94	12	versions	version	NOUN
bptjm-28	94	13	of	of	ADP
bptjm-28	94	14	itself	itself	PRON
bptjm-28	94	15	that	that	PRON
bptjm-28	94	16	exist	exist	VERB
bptjm-28	94	17	in	in	ADP
bptjm-28	94	18	nature21	nature21	ADJ
bptjm-28	94	19	.	.	PUNCT
bptjm-28	95	1	the	the	DET
bptjm-28	95	2	key	key	PROPN
bptjm-28	95	3	di	di	PROPN
bptjm-28	95	4	�	�	PROPN
bptjm-28	95	5	erences	erence	NOUN
bptjm-28	95	6	between	between	ADP
bptjm-28	95	7	such	such	ADJ
bptjm-28	95	8	vectors	vector	NOUN
bptjm-28	95	9	can	can	AUX
bptjm-28	95	10	include	include	VERB
bptjm-28	95	11	the	the	DET
bptjm-28	95	12	length	length	NOUN
bptjm-28	95	13	of	of	ADP
bptjm-28	95	14	gene	gene	NOUN
bptjm-28	95	15	it	it	PRON
bptjm-28	95	16	can	can	AUX
bptjm-28	95	17	hold	hold	VERB
bptjm-28	95	18	,	,	PUNCT
bptjm-28	95	19	various	various	ADJ
bptjm-28	95	20	repair	repair	NOUN
bptjm-28	95	21	enzymes	enzyme	NOUN
bptjm-28	95	22	,	,	PUNCT
bptjm-28	95	23	and	and	CCONJ
bptjm-28	95	24	the	the	DET
bptjm-28	95	25	type	type	NOUN
bptjm-28	95	26	of	of	ADP
bptjm-28	95	27	capsid	capsid	ADJ
bptjm-28	95	28	proteins	protein	NOUN
bptjm-28	95	29	present	present	ADJ
bptjm-28	95	30	for	for	ADP
bptjm-28	95	31	replication	replication	NOUN
bptjm-28	95	32	.	.	PUNCT
bptjm-28	96	1	all	all	PRON
bptjm-28	96	2	of	of	ADP
bptjm-28	96	3	these	these	DET
bptjm-28	96	4	elements	element	NOUN
bptjm-28	96	5	make	make	VERB
bptjm-28	96	6	up	up	ADP
bptjm-28	96	7	the	the	DET
bptjm-28	96	8	speci	speci	PROPN
bptjm-28	96	9	�	�	PROPN
bptjm-28	96	10	c	c	PROPN
bptjm-28	96	11	aav	aav	PROPN
bptjm-28	96	12	vectors	vector	NOUN
bptjm-28	96	13	’	'	PUNCT
bptjm-28	96	14	characteristics	characteristic	NOUN
bptjm-28	96	15	of	of	ADP
bptjm-28	96	16	replication	replication	NOUN
bptjm-28	96	17	speed	speed	NOUN
bptjm-28	96	18	and	and	CCONJ
bptjm-28	96	19	the	the	DET
bptjm-28	96	20	size	size	NOUN
bptjm-28	96	21	of	of	ADP
bptjm-28	96	22	the	the	DET
bptjm-28	96	23	vectors	vector	NOUN
bptjm-28	96	24	.	.	PUNCT
bptjm-28	97	1	additionally	additionally	ADV
bptjm-28	97	2	,	,	PUNCT
bptjm-28	97	3	the	the	DET
bptjm-28	97	4	size	size	NOUN
bptjm-28	97	5	of	of	ADP
bptjm-28	97	6	the	the	DET
bptjm-28	97	7	target	target	NOUN
bptjm-28	97	8	sequence	sequence	NOUN
bptjm-28	97	9	of	of	ADP
bptjm-28	97	10	the	the	DET
bptjm-28	97	11	factor	factor	NOUN
bptjm-28	97	12	needed	need	VERB
bptjm-28	97	13	to	to	PART
bptjm-28	97	14	insert	insert	VERB
bptjm-28	97	15	into	into	ADP
bptjm-28	97	16	the	the	PRON
bptjm-28	97	17	is	be	AUX
bptjm-28	97	18	important	important	ADJ
bptjm-28	97	19	to	to	ADP
bptjm-28	97	20	consider42	consider42	PROPN
bptjm-28	97	21	.	.	PUNCT
bptjm-28	98	1	there	there	PRON
bptjm-28	98	2	is	be	VERB
bptjm-28	98	3	more	more	ADJ
bptjm-28	98	4	research	research	NOUN
bptjm-28	98	5	done	do	VERB
bptjm-28	98	6	on	on	ADP
bptjm-28	98	7	hemophilia	hemophilia	PROPN
bptjm-28	98	8	b	b	PROPN
bptjm-28	98	9	than	than	ADP
bptjm-28	98	10	hemophilia	hemophilia	PROPN
bptjm-28	98	11	a	a	PRON
bptjm-28	98	12	due	due	NOUN
bptjm-28	98	13	to	to	ADP
bptjm-28	98	14	the	the	DET
bptjm-28	98	15	smaller	small	ADJ
bptjm-28	98	16	size	size	NOUN
bptjm-28	98	17	of	of	ADP
bptjm-28	98	18	factor	factor	NOUN
bptjm-28	98	19	9	9	NUM
bptjm-28	98	20	(	(	PUNCT
bptjm-28	98	21	c.	c.	PROPN
bptjm-28	98	22	1.6	1.6	NUM
bptjm-28	98	23	kb	kb	PROPN
bptjm-28	98	24	)	)	PUNCT
bptjm-28	98	25	and	and	CCONJ
bptjm-28	98	26	factor	factor	NOUN
bptjm-28	98	27	8	8	NUM
bptjm-28	98	28	(	(	PUNCT
bptjm-28	98	29	c.	c.	PROPN
bptjm-28	98	30	7	7	NUM
bptjm-28	98	31	kb	kb	PROPN
bptjm-28	98	32	)	)	PUNCT
bptjm-28	98	33	.	.	PUNCT
bptjm-28	99	1	the	the	DET
bptjm-28	99	2	whole	whole	ADJ
bptjm-28	99	3	size	size	NOUN
bptjm-28	99	4	of	of	ADP
bptjm-28	99	5	aav	aav	PROPN
bptjm-28	99	6	vectors	vector	NOUN
bptjm-28	99	7	(	(	PUNCT
bptjm-28	99	8	c.	c.	PROPN
bptjm-28	99	9	4.7	4.7	NUM
bptjm-28	99	10	kb	kb	PROPN
bptjm-28	99	11	)	)	PUNCT
bptjm-28	99	12	limits	limit	VERB
bptjm-28	99	13	berkeley	berkeley	PROPN
bptjm-28	99	14	pharma	pharma	PROPN
bptjm-28	99	15	tech	tech	NOUN
bptjm-28	99	16	journal	journal	NOUN
bptjm-28	99	17	of	of	ADP
bptjm-28	99	18	medicine	medicine	NOUN
bptjm-28	99	19	|	|	ADV
bptjm-28	99	20	126	126	NUM
bptjm-28	99	21	the	the	DET
bptjm-28	99	22	packaging	packaging	NOUN
bptjm-28	99	23	capacity	capacity	NOUN
bptjm-28	100	1	so	so	SCONJ
bptjm-28	100	2	this	this	PRON
bptjm-28	100	3	is	be	AUX
bptjm-28	100	4	another	another	DET
bptjm-28	100	5	limitation	limitation	NOUN
bptjm-28	100	6	of	of	ADP
bptjm-28	100	7	clinical	clinical	ADJ
bptjm-28	100	8	studies	study	NOUN
bptjm-28	100	9	.	.	PUNCT
bptjm-28	101	1	a	a	DET
bptjm-28	101	2	review	review	NOUN
bptjm-28	101	3	paper	paper	NOUN
bptjm-28	101	4	by	by	ADP
bptjm-28	101	5	neinhus	neinhus	PROPN
bptjm-28	101	6	et	et	PROPN
bptjm-28	101	7	.	.	PUNCT
bptjm-28	102	1	al	al	PROPN
bptjm-28	102	2	.	.	PROPN
bptjm-28	102	3	suggested	suggest	VERB
bptjm-28	102	4	that	that	SCONJ
bptjm-28	102	5	the	the	DET
bptjm-28	102	6	recombinant	recombinant	ADJ
bptjm-28	102	7	aav2	aav2	PROPN
bptjm-28	102	8	serotype	serotype	NOUN
bptjm-28	102	9	was	be	AUX
bptjm-28	102	10	used	use	VERB
bptjm-28	102	11	in	in	ADP
bptjm-28	102	12	initial	initial	ADJ
bptjm-28	102	13	studies	study	NOUN
bptjm-28	102	14	because	because	SCONJ
bptjm-28	102	15	it	it	PRON
bptjm-28	102	16	was	be	AUX
bptjm-28	102	17	the	the	DET
bptjm-28	102	18	�	�	PROPN
bptjm-28	102	19	rst	rst	PROPN
bptjm-28	102	20	aav	aav	PROPN
bptjm-28	102	21	vector	vector	NOUN
bptjm-28	102	22	serotype	serotype	NOUN
bptjm-28	102	23	to	to	PART
bptjm-28	102	24	be	be	AUX
bptjm-28	102	25	characterized	characterize	VERB
bptjm-28	102	26	.	.	PUNCT
bptjm-28	103	1	this	this	DET
bptjm-28	103	2	serotype	serotype	NOUN
bptjm-28	103	3	was	be	AUX
bptjm-28	103	4	a	a	DET
bptjm-28	103	5	single	single	ADJ
bptjm-28	103	6	-	-	PUNCT
bptjm-28	103	7	stranded	strand	VERB
bptjm-28	103	8	vector	vector	NOUN
bptjm-28	103	9	and	and	CCONJ
bptjm-28	103	10	was	be	AUX
bptjm-28	103	11	7	7	NUM
bptjm-28	103	12	kb	kb	PROPN
bptjm-28	103	13	in	in	ADP
bptjm-28	103	14	length21	length21	NOUN
bptjm-28	103	15	.	.	PUNCT
bptjm-28	104	1	this	this	DET
bptjm-28	104	2	length	length	NOUN
bptjm-28	104	3	included	include	VERB
bptjm-28	104	4	145	145	NUM
bptjm-28	104	5	base	base	NOUN
bptjm-28	104	6	pairs	pair	NOUN
bptjm-28	104	7	of	of	ADP
bptjm-28	104	8	inverted	inverted	ADJ
bptjm-28	104	9	terminal	terminal	ADJ
bptjm-28	104	10	repeats	repeat	NOUN
bptjm-28	104	11	(	(	PUNCT
bptjm-28	104	12	itrs	itrs	PROPN
bptjm-28	104	13	)	)	PUNCT
bptjm-28	104	14	which	which	PRON
bptjm-28	104	15	are	be	AUX
bptjm-28	104	16	the	the	DET
bptjm-28	104	17	regions	region	NOUN
bptjm-28	104	18	of	of	ADP
bptjm-28	104	19	the	the	DET
bptjm-28	104	20	vector	vector	NOUN
bptjm-28	104	21	that	that	PRON
bptjm-28	104	22	must	must	AUX
bptjm-28	104	23	be	be	AUX
bptjm-28	104	24	preserved	preserve	VERB
bptjm-28	104	25	for	for	SCONJ
bptjm-28	104	26	the	the	DET
bptjm-28	104	27	vector	vector	NOUN
bptjm-28	104	28	to	to	PART
bptjm-28	104	29	allow	allow	VERB
bptjm-28	104	30	packaging	packaging	NOUN
bptjm-28	104	31	and	and	CCONJ
bptjm-28	104	32	further	far	ADV
bptjm-28	104	33	sequencing	sequence	VERB
bptjm-28	104	34	.	.	PUNCT
bptjm-28	105	1	this	this	DET
bptjm-28	105	2	virus	virus	NOUN
bptjm-28	105	3	also	also	ADV
bptjm-28	105	4	included	include	VERB
bptjm-28	105	5	adeno	adeno	NOUN
bptjm-28	105	6	-	-	PUNCT
bptjm-28	105	7	viral	viral	ADJ
bptjm-28	105	8	proteins	protein	NOUN
bptjm-28	105	9	in	in	ADP
bptjm-28	105	10	the	the	DET
bptjm-28	105	11	form	form	NOUN
bptjm-28	105	12	of	of	ADP
bptjm-28	105	13	capsid	capsid	ADJ
bptjm-28	105	14	proteins	protein	NOUN
bptjm-28	105	15	for	for	ADP
bptjm-28	105	16	packaging	packaging	NOUN
bptjm-28	105	17	and	and	CCONJ
bptjm-28	105	18	to	to	PART
bptjm-28	105	19	form	form	VERB
bptjm-28	105	20	viral	viral	ADJ
bptjm-28	105	21	vectors	vector	NOUN
bptjm-28	105	22	.	.	PUNCT
bptjm-28	106	1	another	another	DET
bptjm-28	106	2	comprehensive	comprehensive	ADJ
bptjm-28	106	3	study	study	NOUN
bptjm-28	106	4	by	by	ADP
bptjm-28	106	5	sands	sand	NOUN
bptjm-28	106	6	et	et	PROPN
bptjm-28	106	7	.	.	PUNCT
bptjm-28	107	1	al	al	PROPN
bptjm-28	107	2	.	.	PROPN
bptjm-28	107	3	showed	show	VERB
bptjm-28	107	4	the	the	DET
bptjm-28	107	5	various	various	ADJ
bptjm-28	107	6	types	type	NOUN
bptjm-28	107	7	of	of	ADP
bptjm-28	107	8	aav	aav	PROPN
bptjm-28	107	9	vectors	vector	NOUN
bptjm-28	107	10	’	'	PUNCT
bptjm-28	107	11	serotypes	serotype	NOUN
bptjm-28	107	12	tested	test	VERB
bptjm-28	107	13	through	through	ADP
bptjm-28	107	14	liver	liver	NOUN
bptjm-28	107	15	-	-	PUNCT
bptjm-28	107	16	mediated	mediate	VERB
bptjm-28	107	17	infusion	infusion	NOUN
bptjm-28	107	18	.	.	PUNCT
bptjm-28	108	1	it	it	PRON
bptjm-28	108	2	was	be	AUX
bptjm-28	108	3	known	know	VERB
bptjm-28	108	4	that	that	SCONJ
bptjm-28	108	5	the	the	DET
bptjm-28	108	6	aav2	aav2	PROPN
bptjm-28	108	7	serotype	serotype	NOUN
bptjm-28	108	8	was	be	AUX
bptjm-28	108	9	very	very	ADV
bptjm-28	108	10	versatile	versatile	ADJ
bptjm-28	108	11	and	and	CCONJ
bptjm-28	108	12	could	could	AUX
bptjm-28	108	13	pack	pack	VERB
bptjm-28	108	14	many	many	ADJ
bptjm-28	108	15	genes	gene	NOUN
bptjm-28	108	16	with	with	ADP
bptjm-28	108	17	other	other	ADJ
bptjm-28	108	18	supporting	support	VERB
bptjm-28	108	19	capsid	capsid	NOUN
bptjm-28	108	20	proteins	protein	NOUN
bptjm-28	108	21	.	.	PUNCT
bptjm-28	109	1	as	as	SCONJ
bptjm-28	109	2	aav2	aav2	PROPN
bptjm-28	109	3	was	be	AUX
bptjm-28	109	4	kept	keep	VERB
bptjm-28	109	5	as	as	ADP
bptjm-28	109	6	one	one	NUM
bptjm-28	109	7	type	type	NOUN
bptjm-28	109	8	of	of	ADP
bptjm-28	109	9	control	control	NOUN
bptjm-28	109	10	,	,	PUNCT
bptjm-28	109	11	changing	change	VERB
bptjm-28	109	12	the	the	DET
bptjm-28	109	13	serotype	serotype	NOUN
bptjm-28	109	14	of	of	ADP
bptjm-28	109	15	the	the	DET
bptjm-28	109	16	vector	vector	NOUN
bptjm-28	109	17	greatly	greatly	ADV
bptjm-28	109	18	changed	change	VERB
bptjm-28	109	19	its	its	PRON
bptjm-28	109	20	tropism	tropism	NOUN
bptjm-28	109	21	and	and	CCONJ
bptjm-28	109	22	e	e	NOUN
bptjm-28	109	23	�	�	NOUN
bptjm-28	109	24	ectiveness	ectiveness	ADJ
bptjm-28	109	25	to	to	PART
bptjm-28	109	26	help	help	VERB
bptjm-28	109	27	the	the	DET
bptjm-28	109	28	body	body	NOUN
bptjm-28	109	29	.	.	PUNCT
bptjm-28	110	1	vector	vector	NOUN
bptjm-28	110	2	serotypes	serotype	NOUN
bptjm-28	110	3	1	1	NUM
bptjm-28	110	4	,	,	PUNCT
bptjm-28	110	5	5	5	NUM
bptjm-28	110	6	,	,	PUNCT
bptjm-28	110	7	and	and	CCONJ
bptjm-28	110	8	4	4	NUM
bptjm-28	110	9	were	be	AUX
bptjm-28	110	10	tested	test	VERB
bptjm-28	110	11	to	to	PART
bptjm-28	110	12	be	be	AUX
bptjm-28	110	13	more	more	ADJ
bptjm-28	110	14	e	e	AUX
bptjm-28	110	15	�	�	NOUN
bptjm-28	110	16	cient	cient	VERB
bptjm-28	110	17	in	in	ADP
bptjm-28	110	18	transducing	transducing	NOUN
bptjm-28	110	19	cells	cell	NOUN
bptjm-28	110	20	in	in	ADP
bptjm-28	110	21	the	the	DET
bptjm-28	110	22	murine	murine	ADJ
bptjm-28	110	23	nervous	nervous	ADJ
bptjm-28	110	24	system	system	NOUN
bptjm-28	110	25	or	or	CCONJ
bptjm-28	110	26	within	within	ADP
bptjm-28	110	27	the	the	DET
bptjm-28	110	28	mouse	mouse	NOUN
bptjm-28	110	29	model	model	NOUN
bptjm-28	110	30	.	.	PUNCT
bptjm-28	111	1	because	because	SCONJ
bptjm-28	111	2	the	the	DET
bptjm-28	111	3	liver	liver	NOUN
bptjm-28	111	4	is	be	AUX
bptjm-28	111	5	shown	show	VERB
bptjm-28	111	6	to	to	PART
bptjm-28	111	7	have	have	VERB
bptjm-28	111	8	more	more	ADJ
bptjm-28	111	9	a	a	DET
bptjm-28	111	10	�	�	NOUN
bptjm-28	111	11	nity	nity	NOUN
bptjm-28	111	12	to	to	ADP
bptjm-28	111	13	particular	particular	ADJ
bptjm-28	111	14	capsid	capsid	ADJ
bptjm-28	111	15	proteins	protein	NOUN
bptjm-28	111	16	of	of	ADP
bptjm-28	111	17	di	di	NOUN
bptjm-28	111	18	�	�	PROPN
bptjm-28	111	19	erent	erent	NOUN
bptjm-28	111	20	serotypes	serotype	NOUN
bptjm-28	111	21	,	,	PUNCT
bptjm-28	111	22	vectors	vector	NOUN
bptjm-28	111	23	8	8	NUM
bptjm-28	111	24	and	and	CCONJ
bptjm-28	111	25	9	9	NUM
bptjm-28	111	26	had	have	VERB
bptjm-28	111	27	more	more	ADJ
bptjm-28	111	28	a	a	DET
bptjm-28	111	29	�	�	NOUN
bptjm-28	111	30	nity	nity	NOUN
bptjm-28	111	31	to	to	ADP
bptjm-28	111	32	the	the	DET
bptjm-28	111	33	liver	liver	NOUN
bptjm-28	111	34	greater	great	ADJ
bptjm-28	111	35	than	than	ADP
bptjm-28	111	36	that	that	PRON
bptjm-28	111	37	of	of	ADP
bptjm-28	111	38	serotype	serotype	ADJ
bptjm-28	111	39	aav	aav	NOUN
bptjm-28	111	40	2	2	X
bptjm-28	111	41	.	.	PUNCT
bptjm-28	111	42	aav	aav	PROPN
bptjm-28	111	43	vector	vector	PROPN
bptjm-28	111	44	8	8	NUM
bptjm-28	111	45	was	be	AUX
bptjm-28	111	46	very	very	ADV
bptjm-28	111	47	readily	readily	ADV
bptjm-28	111	48	transduced	transduce	VERB
bptjm-28	111	49	regardless	regardless	ADV
bptjm-28	111	50	of	of	ADP
bptjm-28	111	51	the	the	DET
bptjm-28	111	52	method	method	NOUN
bptjm-28	111	53	it	it	PRON
bptjm-28	111	54	was	be	AUX
bptjm-28	111	55	transferred	transfer	VERB
bptjm-28	111	56	through	through	ADV
bptjm-28	111	57	;	;	PUNCT
bptjm-28	111	58	it	it	PRON
bptjm-28	111	59	was	be	AUX
bptjm-28	111	60	equally	equally	ADV
bptjm-28	111	61	e	e	VERB
bptjm-28	111	62	�	�	NOUN
bptjm-28	111	63	cient	cient	NOUN
bptjm-28	111	64	in	in	ADP
bptjm-28	111	65	both	both	CCONJ
bptjm-28	111	66	the	the	DET
bptjm-28	111	67	intraportal	intraportal	ADJ
bptjm-28	111	68	vein	vein	VERB
bptjm-28	111	69	injection	injection	NOUN
bptjm-28	111	70	and	and	CCONJ
bptjm-28	111	71	by	by	ADP
bptjm-28	111	72	intravenous	intravenous	ADJ
bptjm-28	111	73	(	(	PUNCT
bptjm-28	111	74	tail	tail	NOUN
bptjm-28	111	75	vein	vein	NOUN
bptjm-28	111	76	)	)	PUNCT
bptjm-28	111	77	injection	injection	NOUN
bptjm-28	111	78	.	.	PUNCT
bptjm-28	112	1	additionally	additionally	ADV
bptjm-28	112	2	,	,	PUNCT
bptjm-28	112	3	when	when	SCONJ
bptjm-28	112	4	comparing	compare	VERB
bptjm-28	112	5	the	the	DET
bptjm-28	112	6	e	e	NOUN
bptjm-28	112	7	�	�	NOUN
bptjm-28	112	8	ciency	ciency	NOUN
bptjm-28	112	9	of	of	ADP
bptjm-28	112	10	the	the	DET
bptjm-28	112	11	raav-8	raav-8	PROPN
bptjm-28	112	12	of	of	ADP
bptjm-28	112	13	fix	fix	NOUN
bptjm-28	112	14	administered	administer	VERB
bptjm-28	112	15	through	through	ADP
bptjm-28	112	16	the	the	DET
bptjm-28	112	17	portal	portal	ADJ
bptjm-28	112	18	vein	vein	VERB
bptjm-28	112	19	injection	injection	NOUN
bptjm-28	112	20	and	and	CCONJ
bptjm-28	112	21	tail	tail	NOUN
bptjm-28	112	22	vein	vein	ADJ
bptjm-28	112	23	injection	injection	NOUN
bptjm-28	112	24	in	in	ADP
bptjm-28	112	25	vivo	vivo	ADJ
bptjm-28	112	26	experiments	experiment	NOUN
bptjm-28	112	27	in	in	ADP
bptjm-28	112	28	mice	mouse	NOUN
bptjm-28	112	29	,	,	PUNCT
bptjm-28	112	30	there	there	PRON
bptjm-28	112	31	was	be	VERB
bptjm-28	112	32	an	an	DET
bptjm-28	112	33	equal	equal	ADJ
bptjm-28	112	34	amount	amount	NOUN
bptjm-28	112	35	of	of	ADP
bptjm-28	112	36	expression	expression	NOUN
bptjm-28	112	37	of	of	ADP
bptjm-28	112	38	the	the	DET
bptjm-28	112	39	fix	fix	NOUN
bptjm-28	112	40	factor	factor	NOUN
bptjm-28	112	41	in	in	ADP
bptjm-28	112	42	the	the	DET
bptjm-28	112	43	plasma	plasma	NOUN
bptjm-28	112	44	throughout	throughout	ADP
bptjm-28	112	45	20	20	NUM
bptjm-28	112	46	weeks	week	NOUN
bptjm-28	112	47	of	of	ADP
bptjm-28	112	48	observation	observation	NOUN
bptjm-28	112	49	time	time	NOUN
bptjm-28	112	50	.	.	PUNCT
bptjm-28	113	1	the	the	DET
bptjm-28	113	2	factor	factor	NOUN
bptjm-28	113	3	peaked	peak	VERB
bptjm-28	113	4	during	during	ADP
bptjm-28	113	5	the	the	DET
bptjm-28	113	6	4	4	NUM
bptjm-28	113	7	weeks	week	NOUN
bptjm-28	113	8	mark	mark	NOUN
bptjm-28	113	9	and	and	CCONJ
bptjm-28	113	10	gradually	gradually	ADV
bptjm-28	113	11	decreased	decrease	VERB
bptjm-28	113	12	its	its	PRON
bptjm-28	113	13	expression	expression	NOUN
bptjm-28	113	14	by	by	ADP
bptjm-28	113	15	75	75	NUM
bptjm-28	113	16	%	%	NOUN
bptjm-28	113	17	as	as	ADP
bptjm-28	113	18	by	by	ADP
bptjm-28	113	19	the	the	DET
bptjm-28	113	20	end	end	NOUN
bptjm-28	113	21	of	of	ADP
bptjm-28	113	22	the	the	DET
bptjm-28	113	23	20	20	NUM
bptjm-28	113	24	weeks	week	NOUN
bptjm-28	113	25	.	.	PUNCT
bptjm-28	114	1	the	the	DET
bptjm-28	114	2	vectors	vector	NOUN
bptjm-28	114	3	were	be	AUX
bptjm-28	114	4	prepared	prepare	VERB
bptjm-28	114	5	with	with	ADP
bptjm-28	114	6	the	the	DET
bptjm-28	114	7	help	help	NOUN
bptjm-28	114	8	of	of	ADP
bptjm-28	114	9	a	a	DET
bptjm-28	114	10	native	native	ADJ
bptjm-28	114	11	liver	liver	NOUN
bptjm-28	114	12	cell	cell	NOUN
bptjm-28	114	13	from	from	ADP
bptjm-28	114	14	the	the	DET
bptjm-28	114	15	mouse	mouse	NOUN
bptjm-28	114	16	with	with	ADP
bptjm-28	114	17	the	the	DET
bptjm-28	114	18	double	double	ADJ
bptjm-28	114	19	stranded	strand	VERB
bptjm-28	114	20	vector	vector	NOUN
bptjm-28	114	21	and	and	CCONJ
bptjm-28	114	22	10	10	NUM
bptjm-28	114	23	μg	μg	NOUN
bptjm-28	114	24	of	of	ADP
bptjm-28	114	25	the	the	DET
bptjm-28	114	26	factor	factor	NOUN
bptjm-28	114	27	plasmid	plasmid	NOUN
bptjm-28	114	28	.	.	PUNCT
bptjm-28	115	1	in	in	ADP
bptjm-28	115	2	conclusion	conclusion	NOUN
bptjm-28	115	3	,	,	PUNCT
bptjm-28	115	4	this	this	DET
bptjm-28	115	5	study	study	NOUN
bptjm-28	115	6	has	have	AUX
bptjm-28	115	7	resulted	result	VERB
bptjm-28	115	8	in	in	ADP
bptjm-28	115	9	the	the	DET
bptjm-28	115	10	type	type	NOUN
bptjm-28	115	11	of	of	ADP
bptjm-28	115	12	capsid	capsid	ADJ
bptjm-28	115	13	proteins	protein	NOUN
bptjm-28	115	14	for	for	ADP
bptjm-28	115	15	each	each	DET
bptjm-28	115	16	serotype	serotype	NOUN
bptjm-28	115	17	making	make	VERB
bptjm-28	115	18	the	the	DET
bptjm-28	115	19	aav	aav	PROPN
bptjm-28	115	20	vector	vector	NOUN
bptjm-28	115	21	serotype	serotype	NOUN
bptjm-28	115	22	have	have	VERB
bptjm-28	115	23	a	a	DET
bptjm-28	115	24	di	di	NOUN
bptjm-28	115	25	�	�	PROPN
bptjm-28	115	26	erent	erent	NOUN
bptjm-28	115	27	a	a	DET
bptjm-28	115	28	�	�	NOUN
bptjm-28	115	29	nity	nity	NOUN
bptjm-28	115	30	,	,	PUNCT
bptjm-28	115	31	transduction	transduction	NOUN
bptjm-28	115	32	e	e	NOUN
bptjm-28	115	33	�	�	NOUN
bptjm-28	115	34	ciency	ciency	NOUN
bptjm-28	115	35	,	,	PUNCT
bptjm-28	115	36	and	and	CCONJ
bptjm-28	115	37	tropisms	tropism	NOUN
bptjm-28	115	38	in	in	ADP
bptjm-28	115	39	the	the	DET
bptjm-28	115	40	body22	body22	NOUN
bptjm-28	115	41	.	.	PUNCT
bptjm-28	116	1	limiting	limit	VERB
bptjm-28	116	2	factor	factor	NOUN
bptjm-28	116	3	however	however	ADV
bptjm-28	116	4	,	,	PUNCT
bptjm-28	116	5	the	the	DET
bptjm-28	116	6	transduction	transduction	NOUN
bptjm-28	116	7	of	of	ADP
bptjm-28	116	8	aav	aav	NOUN
bptjm-28	116	9	particles	particle	NOUN
bptjm-28	116	10	into	into	ADP
bptjm-28	116	11	the	the	DET
bptjm-28	116	12	liver	liver	NOUN
bptjm-28	116	13	is	be	AUX
bptjm-28	116	14	limited	limit	VERB
bptjm-28	116	15	by	by	ADP
bptjm-28	116	16	the	the	DET
bptjm-28	116	17	ability	ability	NOUN
bptjm-28	116	18	for	for	SCONJ
bptjm-28	116	19	ssdna	ssdna	NOUN
bptjm-28	116	20	to	to	PART
bptjm-28	116	21	be	be	AUX
bptjm-28	116	22	converted	convert	VERB
bptjm-28	116	23	into	into	ADP
bptjm-28	116	24	dsdna	dsdna	NOUN
bptjm-28	116	25	,	,	PUNCT
bptjm-28	116	26	as	as	SCONJ
bptjm-28	116	27	the	the	DET
bptjm-28	116	28	viral	viral	ADJ
bptjm-28	116	29	mechanism	mechanism	NOUN
bptjm-28	116	30	is	be	AUX
bptjm-28	116	31	dependent	dependent	ADJ
bptjm-28	116	32	on	on	ADP
bptjm-28	116	33	host	host	NOUN
bptjm-28	116	34	machinery23	machinery23	NOUN
bptjm-28	116	35	.	.	PUNCT
bptjm-28	117	1	to	to	PART
bptjm-28	117	2	solve	solve	VERB
bptjm-28	117	3	this	this	DET
bptjm-28	117	4	problem	problem	NOUN
bptjm-28	117	5	,	,	PUNCT
bptjm-28	117	6	a	a	DET
bptjm-28	117	7	study	study	NOUN
bptjm-28	117	8	by	by	ADP
bptjm-28	117	9	nathwani	nathwani	PROPN
bptjm-28	117	10	berkeley	berkeley	PROPN
bptjm-28	117	11	pharma	pharma	PROPN
bptjm-28	117	12	tech	tech	NOUN
bptjm-28	117	13	journal	journal	NOUN
bptjm-28	117	14	of	of	ADP
bptjm-28	117	15	medicine	medicine	NOUN
bptjm-28	117	16	|	|	ADV
bptjm-28	117	17	127	127	NUM
bptjm-28	117	18	et	et	NOUN
bptjm-28	117	19	.	.	PUNCT
bptjm-28	118	1	al	al	PROPN
bptjm-28	118	2	.	.	PROPN
bptjm-28	118	3	devised	devise	VERB
bptjm-28	118	4	a	a	DET
bptjm-28	118	5	liver	liver	NOUN
bptjm-28	118	6	-	-	PUNCT
bptjm-28	118	7	restricted	restrict	VERB
bptjm-28	118	8	mini	mini	ADJ
bptjm-28	118	9	-	-	ADJ
bptjm-28	118	10	human	human	ADJ
bptjm-28	118	11	factor	factor	NOUN
bptjm-28	118	12	ix	ix	X
bptjm-28	118	13	(	(	PUNCT
bptjm-28	118	14	hfix	hfix	NOUN
bptjm-28	118	15	)	)	PUNCT
bptjm-28	118	16	expression	expression	NOUN
bptjm-28	118	17	cassette	cassette	NOUN
bptjm-28	118	18	that	that	PRON
bptjm-28	118	19	allows	allow	VERB
bptjm-28	118	20	aav	aav	PROPN
bptjm-28	118	21	dna	dna	NOUN
bptjm-28	118	22	to	to	PART
bptjm-28	118	23	be	be	AUX
bptjm-28	118	24	packaged	package	VERB
bptjm-28	118	25	as	as	ADP
bptjm-28	118	26	dimers24	dimers24	NOUN
bptjm-28	118	27	.	.	PUNCT
bptjm-28	119	1	as	as	ADP
bptjm-28	119	2	a	a	DET
bptjm-28	119	3	result	result	NOUN
bptjm-28	119	4	,	,	PUNCT
bptjm-28	119	5	hfix	hfix	NOUN
bptjm-28	119	6	expression	expression	NOUN
bptjm-28	119	7	in	in	ADP
bptjm-28	119	8	mice	mice	NOUN
bptjm-28	119	9	models	model	NOUN
bptjm-28	119	10	produced	produce	VERB
bptjm-28	119	11	a	a	DET
bptjm-28	119	12	20	20	NUM
bptjm-28	119	13	-	-	ADJ
bptjm-28	119	14	fold	fold	ADJ
bptjm-28	119	15	increase	increase	NOUN
bptjm-28	119	16	compared	compare	VERB
bptjm-28	119	17	to	to	ADP
bptjm-28	119	18	similar	similar	ADJ
bptjm-28	119	19	single	single	ADJ
bptjm-28	119	20	-	-	PUNCT
bptjm-28	119	21	stranded	strand	VERB
bptjm-28	119	22	aav	aav	NOUN
bptjm-28	119	23	vectors	vector	NOUN
bptjm-28	119	24	(	(	PUNCT
bptjm-28	119	25	ssaav	ssaav	PROPN
bptjm-28	119	26	)	)	PUNCT
bptjm-28	119	27	.	.	PUNCT
bptjm-28	120	1	advantage	advantage	NOUN
bptjm-28	120	2	of	of	ADP
bptjm-28	120	3	aav	aav	NOUN
bptjm-28	120	4	technology	technology	NOUN
bptjm-28	120	5	is	be	AUX
bptjm-28	120	6	that	that	PRON
bptjm-28	120	7	di	di	PROPN
bptjm-28	120	8	�	�	PROPN
bptjm-28	120	9	erent	erent	NOUN
bptjm-28	120	10	serotypes	serotype	NOUN
bptjm-28	120	11	have	have	VERB
bptjm-28	120	12	the	the	DET
bptjm-28	120	13	capability	capability	NOUN
bptjm-28	120	14	of	of	ADP
bptjm-28	120	15	targeting	target	VERB
bptjm-28	120	16	speci	speci	PROPN
bptjm-28	120	17	�	�	PROPN
bptjm-28	120	18	c	c	PROPN
bptjm-28	120	19	tissues	tissue	NOUN
bptjm-28	120	20	.	.	PUNCT
bptjm-28	121	1	aav2	aav2	PROPN
bptjm-28	121	2	serotype	serotype	PROPN
bptjm-28	121	3	has	have	AUX
bptjm-28	121	4	been	be	AUX
bptjm-28	121	5	shown	show	VERB
bptjm-28	121	6	to	to	PART
bptjm-28	121	7	minimize	minimize	VERB
bptjm-28	121	8	tissue	tissue	NOUN
bptjm-28	121	9	tropism	tropism	NOUN
bptjm-28	121	10	as	as	SCONJ
bptjm-28	121	11	its	its	PRON
bptjm-28	121	12	primary	primary	ADJ
bptjm-28	121	13	transduction	transduction	NOUN
bptjm-28	121	14	comes	come	VERB
bptjm-28	121	15	from	from	ADP
bptjm-28	121	16	hepatocytes	hepatocyte	NOUN
bptjm-28	121	17	.	.	PUNCT
bptjm-28	122	1	this	this	PRON
bptjm-28	122	2	also	also	ADV
bptjm-28	122	3	was	be	AUX
bptjm-28	122	4	bene	bene	PROPN
bptjm-28	122	5	�	�	PROPN
bptjm-28	122	6	cial	cial	NOUN
bptjm-28	122	7	in	in	ADP
bptjm-28	122	8	that	that	SCONJ
bptjm-28	122	9	it	it	PRON
bptjm-28	122	10	allowed	allow	VERB
bptjm-28	122	11	researchers	researcher	NOUN
bptjm-28	122	12	to	to	PART
bptjm-28	122	13	use	use	VERB
bptjm-28	122	14	fewer	few	ADJ
bptjm-28	122	15	aav	aav	NOUN
bptjm-28	122	16	particles	particle	NOUN
bptjm-28	122	17	in	in	ADP
bptjm-28	122	18	hemophilia	hemophilia	NOUN
bptjm-28	122	19	patients	patient	NOUN
bptjm-28	122	20	,	,	PUNCT
bptjm-28	122	21	thus	thus	ADV
bptjm-28	122	22	lowering	lower	VERB
bptjm-28	122	23	cytotoxicity	cytotoxicity	NOUN
bptjm-28	122	24	.	.	PUNCT
bptjm-28	123	1	figure	figure	VERB
bptjm-28	123	2	3	3	NUM
bptjm-28	123	3	:	:	PUNCT
bptjm-28	123	4	stages	stage	NOUN
bptjm-28	123	5	in	in	ADP
bptjm-28	123	6	aav	aav	NOUN
bptjm-28	123	7	vector	vector	NOUN
bptjm-28	123	8	delivery	delivery	NOUN
bptjm-28	123	9	and	and	CCONJ
bptjm-28	123	10	transgene	transgene	ADJ
bptjm-28	123	11	expression	expression	NOUN
bptjm-28	123	12	,	,	PUNCT
bptjm-28	123	13	listed	list	VERB
bptjm-28	123	14	in	in	ADP
bptjm-28	123	15	combination	combination	NOUN
bptjm-28	123	16	with	with	ADP
bptjm-28	123	17	some	some	DET
bptjm-28	123	18	resulting	result	VERB
bptjm-28	123	19	proteins	protein	NOUN
bptjm-28	123	20	involved	involve	VERB
bptjm-28	123	21	in	in	ADP
bptjm-28	123	22	the	the	DET
bptjm-28	123	23	process	process	NOUN
bptjm-28	123	24	.	.	PUNCT
bptjm-28	124	1	gene	gene	NOUN
bptjm-28	124	2	target	target	NOUN
bptjm-28	124	3	sequence	sequence	NOUN
bptjm-28	124	4	after	after	ADP
bptjm-28	124	5	designing	design	VERB
bptjm-28	124	6	and	and	CCONJ
bptjm-28	124	7	analyzing	analyzing	NOUN
bptjm-28	124	8	which	which	DET
bptjm-28	124	9	aav	aav	NOUN
bptjm-28	124	10	vector	vector	NOUN
bptjm-28	124	11	to	to	PART
bptjm-28	124	12	use	use	VERB
bptjm-28	124	13	for	for	ADP
bptjm-28	124	14	such	such	DET
bptjm-28	124	15	an	an	DET
bptjm-28	124	16	experiment	experiment	NOUN
bptjm-28	124	17	,	,	PUNCT
bptjm-28	124	18	a	a	DET
bptjm-28	124	19	good	good	ADJ
bptjm-28	124	20	gene	gene	NOUN
bptjm-28	124	21	target	target	NOUN
bptjm-28	124	22	sequence	sequence	NOUN
bptjm-28	124	23	is	be	AUX
bptjm-28	124	24	necessary	necessary	ADJ
bptjm-28	124	25	to	to	PART
bptjm-28	124	26	insert	insert	VERB
bptjm-28	124	27	into	into	ADP
bptjm-28	124	28	the	the	DET
bptjm-28	124	29	aav	aav	NOUN
bptjm-28	124	30	vector	vector	NOUN
bptjm-28	124	31	to	to	PART
bptjm-28	124	32	express	express	VERB
bptjm-28	124	33	the	the	DET
bptjm-28	124	34	needed	need	VERB
bptjm-28	124	35	vectors	vector	NOUN
bptjm-28	124	36	.	.	PUNCT
bptjm-28	125	1	many	many	ADJ
bptjm-28	125	2	pharmaceutical	pharmaceutical	ADJ
bptjm-28	125	3	companies	company	NOUN
bptjm-28	125	4	such	such	ADJ
bptjm-28	125	5	as	as	ADP
bptjm-28	125	6	biomarin	biomarin	NOUN
bptjm-28	125	7	pharmaceuticals	pharmaceutical	NOUN
bptjm-28	125	8	,	,	PUNCT
bptjm-28	125	9	spark	spark	NOUN
bptjm-28	125	10	therapeutics	therapeutic	NOUN
bptjm-28	125	11	,	,	PUNCT
bptjm-28	125	12	p	p	PROPN
bptjm-28	125	13	�	�	PROPN
bptjm-28	125	14	zer	zer	NOUN
bptjm-28	125	15	,	,	PUNCT
bptjm-28	125	16	and	and	CCONJ
bptjm-28	125	17	uniqure25	uniqure25	NOUN
bptjm-28	125	18	.	.	PUNCT
bptjm-28	126	1	the	the	DET
bptjm-28	126	2	following	follow	VERB
bptjm-28	126	3	companies	company	NOUN
bptjm-28	126	4	have	have	AUX
bptjm-28	126	5	already	already	ADV
bptjm-28	126	6	designed	design	VERB
bptjm-28	126	7	and	and	CCONJ
bptjm-28	126	8	inserted	insert	VERB
bptjm-28	126	9	the	the	DET
bptjm-28	126	10	target	target	NOUN
bptjm-28	126	11	fviii	fviii	NOUN
bptjm-28	126	12	or	or	CCONJ
bptjm-28	126	13	fix	fix	VERB
bptjm-28	126	14	gene	gene	NOUN
bptjm-28	126	15	sequence	sequence	NOUN
bptjm-28	126	16	gene	gene	NOUN
bptjm-28	126	17	therapy	therapy	NOUN
bptjm-28	126	18	products	product	NOUN
bptjm-28	126	19	into	into	ADP
bptjm-28	126	20	the	the	DET
bptjm-28	126	21	vectors	vector	NOUN
bptjm-28	126	22	and	and	CCONJ
bptjm-28	126	23	are	be	AUX
bptjm-28	126	24	in	in	ADP
bptjm-28	126	25	clinical	clinical	ADJ
bptjm-28	126	26	trials	trial	NOUN
bptjm-28	126	27	evaluated	evaluate	VERB
bptjm-28	126	28	in	in	ADP
bptjm-28	126	29	phase	phase	NOUN
bptjm-28	126	30	iii	iii	NUM
bptjm-28	126	31	studies	study	NOUN
bptjm-28	126	32	.	.	PUNCT
bptjm-28	127	1	a	a	DET
bptjm-28	127	2	particular	particular	ADJ
bptjm-28	127	3	review	review	NOUN
bptjm-28	127	4	paper	paper	NOUN
bptjm-28	127	5	by	by	ADP
bptjm-28	127	6	doshi	doshi	PROPN
bptjm-28	127	7	et	et	PROPN
bptjm-28	127	8	.	.	PUNCT
bptjm-28	128	1	al.26	al.26	PROPN
bptjm-28	128	2	discussed	discuss	VERB
bptjm-28	128	3	clinical	clinical	ADJ
bptjm-28	128	4	trials	trial	NOUN
bptjm-28	128	5	that	that	PRON
bptjm-28	128	6	suggested	suggest	VERB
bptjm-28	128	7	broadening	broaden	VERB
bptjm-28	128	8	the	the	DET
bptjm-28	128	9	gene	gene	NOUN
bptjm-28	128	10	berkeley	berkeley	PROPN
bptjm-28	128	11	pharma	pharma	PROPN
bptjm-28	128	12	tech	tech	NOUN
bptjm-28	128	13	journal	journal	NOUN
bptjm-28	128	14	of	of	ADP
bptjm-28	128	15	medicine	medicine	NOUN
bptjm-28	128	16	|	|	ADV
bptjm-28	128	17	128	128	NUM
bptjm-28	128	18	therapy	therapy	NOUN
bptjm-28	128	19	vector	vector	NOUN
bptjm-28	128	20	applicability	applicability	NOUN
bptjm-28	128	21	with	with	ADP
bptjm-28	128	22	patients	patient	NOUN
bptjm-28	128	23	who	who	PRON
bptjm-28	128	24	had	have	VERB
bptjm-28	128	25	pre	pre	VERB
bptjm-28	128	26	-	-	ADJ
bptjm-28	128	27	existing	exist	VERB
bptjm-28	128	28	neutralizing	neutralizing	ADJ
bptjm-28	128	29	alloantibodies	alloantibody	NOUN
bptjm-28	128	30	to	to	ADP
bptjm-28	128	31	the	the	DET
bptjm-28	128	32	vector	vector	NOUN
bptjm-28	128	33	or	or	CCONJ
bptjm-28	128	34	in	in	ADP
bptjm-28	128	35	other	other	ADJ
bptjm-28	128	36	words	word	NOUN
bptjm-28	128	37	the	the	DET
bptjm-28	128	38	clotting	clotting	NOUN
bptjm-28	128	39	factors	factor	NOUN
bptjm-28	128	40	.	.	PUNCT
bptjm-28	129	1	here	here	ADV
bptjm-28	129	2	the	the	DET
bptjm-28	129	3	vector	vector	NOUN
bptjm-28	129	4	genome	genome	NOUN
bptjm-28	129	5	is	be	AUX
bptjm-28	129	6	manipulated	manipulate	VERB
bptjm-28	129	7	so	so	SCONJ
bptjm-28	129	8	that	that	SCONJ
bptjm-28	129	9	the	the	DET
bptjm-28	129	10	needed	need	VERB
bptjm-28	129	11	gene	gene	NOUN
bptjm-28	129	12	target	target	NOUN
bptjm-28	129	13	sequence	sequence	NOUN
bptjm-28	129	14	can	can	AUX
bptjm-28	129	15	replace	replace	VERB
bptjm-28	129	16	the	the	DET
bptjm-28	129	17	vector	vector	NOUN
bptjm-28	129	18	sequence	sequence	NOUN
bptjm-28	129	19	under	under	ADP
bptjm-28	129	20	a	a	DET
bptjm-28	129	21	tissue	tissue	NOUN
bptjm-28	129	22	-	-	PUNCT
bptjm-28	129	23	speci	speci	NOUN
bptjm-28	129	24	�	�	PROPN
bptjm-28	129	25	c	c	PROPN
bptjm-28	129	26	promoter	promoter	NOUN
bptjm-28	129	27	to	to	PART
bptjm-28	129	28	make	make	VERB
bptjm-28	129	29	a	a	DET
bptjm-28	129	30	recombinant	recombinant	ADJ
bptjm-28	129	31	aav	aav	NOUN
bptjm-28	129	32	vector	vector	NOUN
bptjm-28	129	33	(	(	PUNCT
bptjm-28	129	34	ravv	ravv	ADJ
bptjm-28	129	35	)	)	PUNCT
bptjm-28	129	36	.	.	PUNCT
bptjm-28	130	1	in	in	ADP
bptjm-28	130	2	totality	totality	NOUN
bptjm-28	130	3	,	,	PUNCT
bptjm-28	130	4	the	the	DET
bptjm-28	130	5	completed	complete	VERB
bptjm-28	130	6	modi	modi	PROPN
bptjm-28	130	7	�	�	PROPN
bptjm-28	130	8	ed	ed	PROPN
bptjm-28	130	9	aav	aav	PROPN
bptjm-28	130	10	vector	vector	NOUN
bptjm-28	130	11	in	in	ADP
bptjm-28	130	12	order	order	NOUN
bptjm-28	130	13	included	include	VERB
bptjm-28	130	14	the	the	DET
bptjm-28	130	15	itr	itr	NOUN
bptjm-28	130	16	,	,	PUNCT
bptjm-28	130	17	promoter	promoter	NOUN
bptjm-28	130	18	,	,	PUNCT
bptjm-28	130	19	inhibitor	inhibitor	NOUN
bptjm-28	130	20	,	,	PUNCT
bptjm-28	130	21	transgene	transgene	NOUN
bptjm-28	130	22	,	,	PUNCT
bptjm-28	130	23	polya	polya	NOUN
bptjm-28	130	24	,	,	PUNCT
bptjm-28	130	25	and	and	CCONJ
bptjm-28	130	26	itr	itr	NOUN
bptjm-28	130	27	.	.	PUNCT
bptjm-28	131	1	the	the	DET
bptjm-28	131	2	results	result	NOUN
bptjm-28	131	3	varied	varied	ADJ
bptjm-28	131	4	based	base	VERB
bptjm-28	131	5	on	on	ADP
bptjm-28	131	6	the	the	DET
bptjm-28	131	7	way	way	NOUN
bptjm-28	131	8	the	the	DET
bptjm-28	131	9	aav	aav	PROPN
bptjm-28	131	10	vector	vector	NOUN
bptjm-28	131	11	was	be	AUX
bptjm-28	131	12	given	give	VERB
bptjm-28	131	13	via	via	ADP
bptjm-28	131	14	skeletal	skeletal	ADJ
bptjm-28	131	15	muscle	muscle	NOUN
bptjm-28	131	16	,	,	PUNCT
bptjm-28	131	17	liver	liver	NOUN
bptjm-28	131	18	-	-	PUNCT
bptjm-28	131	19	directed	direct	VERB
bptjm-28	131	20	,	,	PUNCT
bptjm-28	131	21	and	and	CCONJ
bptjm-28	131	22	intramuscular	intramuscular	ADJ
bptjm-28	131	23	trials	trial	NOUN
bptjm-28	131	24	.	.	PUNCT
bptjm-28	132	1	aav	aav	PROPN
bptjm-28	132	2	administration	administration	PROPN
bptjm-28	132	3	re	re	PROPN
bptjm-28	132	4	�	�	PROPN
bptjm-28	132	5	ning	ning	PROPN
bptjm-28	132	6	administration	administration	PROPN
bptjm-28	132	7	of	of	ADP
bptjm-28	132	8	aav	aav	PROPN
bptjm-28	132	9	gene	gene	NOUN
bptjm-28	132	10	therapy	therapy	NOUN
bptjm-28	132	11	so	so	SCONJ
bptjm-28	132	12	as	as	SCONJ
bptjm-28	132	13	to	to	PART
bptjm-28	132	14	optimize	optimize	VERB
bptjm-28	132	15	“	"	PUNCT
bptjm-28	132	16	uptake	uptake	ADJ
bptjm-28	132	17	”	"	PUNCT
bptjm-28	132	18	of	of	ADP
bptjm-28	132	19	vectors	vector	NOUN
bptjm-28	132	20	,	,	PUNCT
bptjm-28	132	21	induce	induce	VERB
bptjm-28	132	22	expression	expression	NOUN
bptjm-28	132	23	,	,	PUNCT
bptjm-28	132	24	provide	provide	VERB
bptjm-28	132	25	longer	long	ADV
bptjm-28	132	26	-	-	PUNCT
bptjm-28	132	27	lasting	last	VERB
bptjm-28	132	28	e	e	NOUN
bptjm-28	132	29	�	�	NOUN
bptjm-28	132	30	ects	ect	NOUN
bptjm-28	132	31	,	,	PUNCT
bptjm-28	132	32	and	and	CCONJ
bptjm-28	132	33	reduce	reduce	VERB
bptjm-28	132	34	liver	liver	NOUN
bptjm-28	132	35	damage	damage	NOUN
bptjm-28	132	36	/	/	SYM
bptjm-28	132	37	minimize	minimize	NOUN
bptjm-28	132	38	immune	immune	ADJ
bptjm-28	132	39	system	system	NOUN
bptjm-28	132	40	e	e	NOUN
bptjm-28	132	41	�	�	NOUN
bptjm-28	132	42	ects	ect	VERB
bptjm-28	132	43	.	.	PUNCT
bptjm-28	133	1	the	the	DET
bptjm-28	133	2	site	site	NOUN
bptjm-28	133	3	of	of	ADP
bptjm-28	133	4	infection	infection	NOUN
bptjm-28	133	5	can	can	AUX
bptjm-28	133	6	greatly	greatly	ADV
bptjm-28	133	7	increase	increase	VERB
bptjm-28	133	8	or	or	CCONJ
bptjm-28	133	9	decrease	decrease	VERB
bptjm-28	133	10	the	the	DET
bptjm-28	133	11	e	e	NOUN
bptjm-28	133	12	�	�	NOUN
bptjm-28	133	13	ciency	ciency	NOUN
bptjm-28	133	14	of	of	ADP
bptjm-28	133	15	the	the	DET
bptjm-28	133	16	transduction	transduction	NOUN
bptjm-28	133	17	of	of	ADP
bptjm-28	133	18	aav	aav	NOUN
bptjm-28	133	19	in	in	ADP
bptjm-28	133	20	the	the	DET
bptjm-28	133	21	body	body	NOUN
bptjm-28	133	22	.	.	PUNCT
bptjm-28	134	1	intraportal	intraportal	ADJ
bptjm-28	134	2	vein	vein	ADJ
bptjm-28	134	3	injection	injection	NOUN
bptjm-28	134	4	includes	include	VERB
bptjm-28	134	5	an	an	DET
bptjm-28	134	6	infusion	infusion	NOUN
bptjm-28	134	7	directly	directly	ADV
bptjm-28	134	8	to	to	ADP
bptjm-28	134	9	the	the	DET
bptjm-28	134	10	portal	portal	ADJ
bptjm-28	134	11	vein	vein	NOUN
bptjm-28	134	12	of	of	ADP
bptjm-28	134	13	the	the	DET
bptjm-28	134	14	liver21	liver21	NOUN
bptjm-28	134	15	.	.	PUNCT
bptjm-28	135	1	according	accord	VERB
bptjm-28	135	2	to	to	ADP
bptjm-28	135	3	a	a	DET
bptjm-28	135	4	study	study	NOUN
bptjm-28	135	5	by	by	ADP
bptjm-28	135	6	nienhuis	nienhuis	PROPN
bptjm-28	135	7	et	et	PROPN
bptjm-28	135	8	.	.	PUNCT
bptjm-28	136	1	al	al	PROPN
bptjm-28	136	2	.	.	PROPN
bptjm-28	137	1	from	from	ADP
bptjm-28	137	2	the	the	DET
bptjm-28	137	3	university	university	PROPN
bptjm-28	137	4	of	of	ADP
bptjm-28	137	5	london	london	PROPN
bptjm-28	137	6	,	,	PUNCT
bptjm-28	137	7	raav2	raav2	PROPN
bptjm-28	137	8	was	be	AUX
bptjm-28	137	9	shown	show	VERB
bptjm-28	137	10	to	to	PART
bptjm-28	137	11	have	have	VERB
bptjm-28	137	12	the	the	DET
bptjm-28	137	13	same	same	ADJ
bptjm-28	137	14	e	e	NOUN
bptjm-28	137	15	�	�	NOUN
bptjm-28	137	16	ciency	ciency	NOUN
bptjm-28	137	17	as	as	ADP
bptjm-28	137	18	the	the	DET
bptjm-28	137	19	portal	portal	PROPN
bptjm-28	137	20	vein	vein	VERB
bptjm-28	137	21	method	method	NOUN
bptjm-28	137	22	and	and	CCONJ
bptjm-28	137	23	the	the	DET
bptjm-28	137	24	peripheral	peripheral	ADJ
bptjm-28	137	25	vein	vein	ADJ
bptjm-28	137	26	infusion	infusion	NOUN
bptjm-28	137	27	method	method	NOUN
bptjm-28	137	28	.	.	PUNCT
bptjm-28	138	1	initially	initially	ADV
bptjm-28	138	2	,	,	PUNCT
bptjm-28	138	3	it	it	PRON
bptjm-28	138	4	was	be	AUX
bptjm-28	138	5	thought	think	VERB
bptjm-28	138	6	that	that	SCONJ
bptjm-28	138	7	a	a	DET
bptjm-28	138	8	portal	portal	ADJ
bptjm-28	138	9	vein	vein	ADJ
bptjm-28	138	10	injection	injection	NOUN
bptjm-28	138	11	was	be	AUX
bptjm-28	138	12	needed	need	VERB
bptjm-28	138	13	to	to	PART
bptjm-28	138	14	secure	secure	VERB
bptjm-28	138	15	the	the	DET
bptjm-28	138	16	liver	liver	NOUN
bptjm-28	138	17	transduction	transduction	NOUN
bptjm-28	138	18	in	in	ADP
bptjm-28	138	19	the	the	DET
bptjm-28	138	20	mice	mouse	NOUN
bptjm-28	138	21	but	but	CCONJ
bptjm-28	138	22	this	this	PRON
bptjm-28	138	23	was	be	AUX
bptjm-28	138	24	not	not	PART
bptjm-28	138	25	true	true	ADJ
bptjm-28	138	26	.	.	PUNCT
bptjm-28	139	1	the	the	DET
bptjm-28	139	2	transduction	transduction	NOUN
bptjm-28	139	3	was	be	AUX
bptjm-28	139	4	largely	largely	ADV
bptjm-28	139	5	a	a	DET
bptjm-28	139	6	�	�	NOUN
bptjm-28	139	7	ected	ecte	VERB
bptjm-28	139	8	by	by	ADP
bptjm-28	139	9	the	the	DET
bptjm-28	139	10	types	type	NOUN
bptjm-28	139	11	of	of	ADP
bptjm-28	139	12	capsid	capsid	ADJ
bptjm-28	139	13	proteins	protein	NOUN
bptjm-28	139	14	present	present	ADJ
bptjm-28	139	15	in	in	ADP
bptjm-28	139	16	the	the	DET
bptjm-28	139	17	aav	aav	PROPN
bptjm-28	139	18	vector	vector	NOUN
bptjm-28	139	19	serotype	serotype	PROPN
bptjm-28	139	20	.	.	PUNCT
bptjm-28	140	1	based	base	VERB
bptjm-28	140	2	on	on	ADP
bptjm-28	140	3	the	the	DET
bptjm-28	140	4	study	study	NOUN
bptjm-28	140	5	by	by	ADP
bptjm-28	140	6	doshi	doshi	PROPN
bptjm-28	140	7	et	et	PROPN
bptjm-28	140	8	.	.	PUNCT
bptjm-28	141	1	al	al	PROPN
bptjm-28	141	2	.	.	PROPN
bptjm-28	141	3	suggesting	suggest	VERB
bptjm-28	141	4	that	that	SCONJ
bptjm-28	141	5	patients	patient	NOUN
bptjm-28	141	6	who	who	PRON
bptjm-28	141	7	already	already	ADV
bptjm-28	141	8	had	have	VERB
bptjm-28	141	9	existing	exist	VERB
bptjm-28	141	10	neutralizing	neutralize	VERB
bptjm-28	141	11	antibodies	antibody	NOUN
bptjm-28	141	12	(	(	PUNCT
bptjm-28	141	13	nabs	nab	NOUN
bptjm-28	141	14	)	)	PUNCT
bptjm-28	141	15	in	in	ADP
bptjm-28	141	16	the	the	DET
bptjm-28	141	17	liver	liver	NOUN
bptjm-28	141	18	—	—	PUNCT
bptjm-28	141	19	directed	direct	VERB
bptjm-28	141	20	gene	gene	NOUN
bptjm-28	141	21	therapy	therapy	NOUN
bptjm-28	141	22	showed	show	VERB
bptjm-28	141	23	that	that	SCONJ
bptjm-28	141	24	the	the	DET
bptjm-28	141	25	aav	aav	PROPN
bptjm-28	141	26	transduction	transduction	NOUN
bptjm-28	141	27	e	e	NOUN
bptjm-28	141	28	�	�	NOUN
bptjm-28	141	29	ciency	ciency	NOUN
bptjm-28	141	30	was	be	AUX
bptjm-28	141	31	hindered	hinder	VERB
bptjm-28	141	32	by	by	ADP
bptjm-28	141	33	pre	pre	ADJ
bptjm-28	141	34	-	-	ADJ
bptjm-28	141	35	existing	existing	ADJ
bptjm-28	141	36	nabs	nab	NOUN
bptjm-28	141	37	.	.	PUNCT
bptjm-28	142	1	(	(	PUNCT
bptjm-28	142	2	26	26	NUM
bptjm-28	142	3	)	)	PUNCT
bptjm-28	142	4	although	although	SCONJ
bptjm-28	142	5	nabs	nab	NOUN
bptjm-28	142	6	can	can	AUX
bptjm-28	142	7	be	be	AUX
bptjm-28	142	8	present	present	ADJ
bptjm-28	142	9	in	in	ADP
bptjm-28	142	10	30	30	NUM
bptjm-28	142	11	-	-	SYM
bptjm-28	142	12	70	70	NUM
bptjm-28	142	13	%	%	NOUN
bptjm-28	142	14	of	of	ADP
bptjm-28	142	15	the	the	DET
bptjm-28	142	16	population	population	NOUN
bptjm-28	142	17	,	,	PUNCT
bptjm-28	142	18	immunosuppressors	immunosuppressor	NOUN
bptjm-28	142	19	were	be	AUX
bptjm-28	142	20	used	use	VERB
bptjm-28	142	21	in	in	ADP
bptjm-28	142	22	subsequent	subsequent	ADJ
bptjm-28	142	23	trials	trial	NOUN
bptjm-28	142	24	involving	involve	VERB
bptjm-28	142	25	the	the	DET
bptjm-28	142	26	liverdirected	liverdirecte	VERB
bptjm-28	142	27	transduction	transduction	NOUN
bptjm-28	142	28	.	.	PUNCT
bptjm-28	143	1	contrastingly	contrastingly	ADV
bptjm-28	143	2	,	,	PUNCT
bptjm-28	143	3	the	the	DET
bptjm-28	143	4	intramuscular	intramuscular	ADJ
bptjm-28	143	5	trial	trial	NOUN
bptjm-28	143	6	did	do	AUX
bptjm-28	143	7	not	not	PART
bptjm-28	143	8	have	have	VERB
bptjm-28	143	9	this	this	DET
bptjm-28	143	10	e	e	NOUN
bptjm-28	143	11	�	�	NOUN
bptjm-28	143	12	ect	ect	ADJ
bptjm-28	143	13	.	.	PUNCT
bptjm-28	144	1	another	another	DET
bptjm-28	144	2	method	method	NOUN
bptjm-28	144	3	of	of	ADP
bptjm-28	144	4	vector	vector	NOUN
bptjm-28	144	5	infusion	infusion	NOUN
bptjm-28	144	6	is	be	AUX
bptjm-28	144	7	direct	direct	ADJ
bptjm-28	144	8	intraparenchymal	intraparenchymal	ADJ
bptjm-28	144	9	injection	injection	NOUN
bptjm-28	144	10	.	.	PUNCT
bptjm-28	145	1	a	a	DET
bptjm-28	145	2	study	study	NOUN
bptjm-28	145	3	by	by	ADP
bptjm-28	145	4	sands	sand	NOUN
bptjm-28	145	5	et	et	PROPN
bptjm-28	145	6	.	.	PUNCT
bptjm-28	146	1	al	al	PROPN
bptjm-28	146	2	.	.	PROPN
bptjm-28	146	3	suggested	suggest	VERB
bptjm-28	146	4	that	that	SCONJ
bptjm-28	146	5	a	a	DET
bptjm-28	146	6	direct	direct	ADJ
bptjm-28	146	7	injection	injection	NOUN
bptjm-28	146	8	of	of	ADP
bptjm-28	146	9	an	an	DET
bptjm-28	146	10	aav2	aav2	PROPN
bptjm-28	146	11	vector	vector	NOUN
bptjm-28	146	12	into	into	ADP
bptjm-28	146	13	the	the	DET
bptjm-28	146	14	liver	liver	NOUN
bptjm-28	146	15	parenchyma	parenchyma	NOUN
bptjm-28	146	16	which	which	PRON
bptjm-28	146	17	results	result	VERB
bptjm-28	146	18	in	in	ADP
bptjm-28	146	19	a	a	DET
bptjm-28	146	20	relatively	relatively	ADV
bptjm-28	146	21	widespread	widespread	ADJ
bptjm-28	146	22	transduction	transduction	NOUN
bptjm-28	146	23	throughout	throughout	ADP
bptjm-28	146	24	the	the	DET
bptjm-28	146	25	liver22	liver22	NOUN
bptjm-28	146	26	.	.	PUNCT
bptjm-28	147	1	this	this	DET
bptjm-28	147	2	method	method	NOUN
bptjm-28	147	3	also	also	ADV
bptjm-28	147	4	retains	retain	VERB
bptjm-28	147	5	the	the	DET
bptjm-28	147	6	aav	aav	NOUN
bptjm-28	147	7	gene	gene	NOUN
bptjm-28	147	8	expression	expression	NOUN
bptjm-28	147	9	for	for	ADP
bptjm-28	147	10	a	a	DET
bptjm-28	147	11	longer	long	ADJ
bptjm-28	147	12	period	period	NOUN
bptjm-28	147	13	of	of	ADP
bptjm-28	147	14	time	time	NOUN
bptjm-28	147	15	in	in	ADP
bptjm-28	147	16	the	the	DET
bptjm-28	147	17	body	body	NOUN
bptjm-28	147	18	.	.	PUNCT
bptjm-28	148	1	berkeley	berkeley	PROPN
bptjm-28	148	2	pharma	pharma	PROPN
bptjm-28	148	3	tech	tech	PROPN
bptjm-28	148	4	journal	journal	NOUN
bptjm-28	148	5	of	of	ADP
bptjm-28	148	6	medicine	medicine	NOUN
bptjm-28	148	7	|	|	ADV
bptjm-28	148	8	129	129	NUM
bptjm-28	148	9	figure	figure	NOUN
bptjm-28	148	10	4	4	NUM
bptjm-28	148	11	:	:	PUNCT
bptjm-28	148	12	the	the	DET
bptjm-28	148	13	three	three	NUM
bptjm-28	148	14	types	type	NOUN
bptjm-28	148	15	of	of	ADP
bptjm-28	148	16	aav	aav	NOUN
bptjm-28	148	17	administration	administration	NOUN
bptjm-28	148	18	methods	method	NOUN
bptjm-28	148	19	dosage	dosage	NOUN
bptjm-28	148	20	scientists	scientist	NOUN
bptjm-28	148	21	must	must	AUX
bptjm-28	148	22	determine	determine	VERB
bptjm-28	148	23	the	the	DET
bptjm-28	148	24	correct	correct	ADJ
bptjm-28	148	25	dose	dose	NOUN
bptjm-28	148	26	of	of	ADP
bptjm-28	148	27	aav	aav	PROPN
bptjm-28	148	28	vector	vector	NOUN
bptjm-28	148	29	particles	particle	NOUN
bptjm-28	148	30	injected	inject	VERB
bptjm-28	148	31	into	into	ADP
bptjm-28	148	32	the	the	DET
bptjm-28	148	33	patients	patient	NOUN
bptjm-28	148	34	,	,	PUNCT
bptjm-28	148	35	as	as	SCONJ
bptjm-28	148	36	a	a	DET
bptjm-28	148	37	low	low	ADJ
bptjm-28	148	38	concentration	concentration	NOUN
bptjm-28	148	39	may	may	AUX
bptjm-28	148	40	not	not	PART
bptjm-28	148	41	produce	produce	VERB
bptjm-28	148	42	a	a	DET
bptjm-28	148	43	robust	robust	ADJ
bptjm-28	148	44	amount	amount	NOUN
bptjm-28	148	45	of	of	ADP
bptjm-28	148	46	expression	expression	NOUN
bptjm-28	148	47	,	,	PUNCT
bptjm-28	148	48	while	while	SCONJ
bptjm-28	148	49	a	a	DET
bptjm-28	148	50	dosage	dosage	NOUN
bptjm-28	148	51	that	that	PRON
bptjm-28	148	52	is	be	AUX
bptjm-28	148	53	too	too	ADV
bptjm-28	148	54	high	high	ADJ
bptjm-28	148	55	may	may	AUX
bptjm-28	148	56	cause	cause	VERB
bptjm-28	148	57	an	an	DET
bptjm-28	148	58	immune	immune	ADJ
bptjm-28	148	59	response	response	NOUN
bptjm-28	148	60	and	and	CCONJ
bptjm-28	148	61	liver	liver	NOUN
bptjm-28	148	62	damage	damage	NOUN
bptjm-28	148	63	.	.	PUNCT
bptjm-28	149	1	scientists	scientist	NOUN
bptjm-28	149	2	have	have	AUX
bptjm-28	149	3	sought	seek	VERB
bptjm-28	149	4	to	to	PART
bptjm-28	149	5	address	address	VERB
bptjm-28	149	6	this	this	DET
bptjm-28	149	7	issue	issue	NOUN
bptjm-28	149	8	by	by	ADP
bptjm-28	149	9	increasing	increase	VERB
bptjm-28	149	10	the	the	DET
bptjm-28	149	11	transduction	transduction	NOUN
bptjm-28	149	12	of	of	ADP
bptjm-28	149	13	the	the	DET
bptjm-28	149	14	vector	vector	NOUN
bptjm-28	149	15	into	into	ADP
bptjm-28	149	16	cells	cell	NOUN
bptjm-28	149	17	such	such	ADJ
bptjm-28	149	18	that	that	SCONJ
bptjm-28	149	19	fewer	few	ADJ
bptjm-28	149	20	vector	vector	NOUN
bptjm-28	149	21	particles	particle	NOUN
bptjm-28	149	22	are	be	AUX
bptjm-28	149	23	needed	need	VERB
bptjm-28	149	24	and	and	CCONJ
bptjm-28	149	25	thus	thus	ADV
bptjm-28	149	26	limiting	limit	VERB
bptjm-28	149	27	host	host	NOUN
bptjm-28	149	28	immunity	immunity	NOUN
bptjm-28	149	29	.	.	PUNCT
bptjm-28	150	1	minimizing	minimize	VERB
bptjm-28	150	2	immunogenicity	immunogenicity	NOUN
bptjm-28	150	3	there	there	PRON
bptjm-28	150	4	are	be	VERB
bptjm-28	150	5	two	two	NUM
bptjm-28	150	6	ways	way	NOUN
bptjm-28	150	7	to	to	PART
bptjm-28	150	8	decrease	decrease	VERB
bptjm-28	150	9	immunogenicity	immunogenicity	NOUN
bptjm-28	150	10	;	;	PUNCT
bptjm-28	150	11	one	one	NUM
bptjm-28	150	12	such	such	ADJ
bptjm-28	150	13	measure	measure	NOUN
bptjm-28	150	14	refers	refer	VERB
bptjm-28	150	15	to	to	ADP
bptjm-28	150	16	a	a	DET
bptjm-28	150	17	process	process	NOUN
bptjm-28	150	18	known	know	VERB
bptjm-28	150	19	as	as	ADP
bptjm-28	150	20	site	site	NOUN
bptjm-28	150	21	directed	direct	VERB
bptjm-28	150	22	mutagenesis	mutagenesis	NOUN
bptjm-28	150	23	.	.	PUNCT
bptjm-28	151	1	two	two	NUM
bptjm-28	151	2	vector	vector	NOUN
bptjm-28	151	3	serotypes	serotype	NOUN
bptjm-28	151	4	currently	currently	ADV
bptjm-28	151	5	being	be	AUX
bptjm-28	151	6	used	use	VERB
bptjm-28	151	7	in	in	ADP
bptjm-28	151	8	clinical	clinical	ADJ
bptjm-28	151	9	studies	study	NOUN
bptjm-28	151	10	,	,	PUNCT
bptjm-28	151	11	raav	raav	NOUN
bptjm-28	151	12	-	-	PUNCT
bptjm-28	151	13	dj	dj	NOUN
bptjm-28	151	14	and	and	CCONJ
bptjm-28	151	15	raav	raav	NOUN
bptjm-28	151	16	-	-	PUNCT
bptjm-28	151	17	lk03	lk03	PROPN
bptjm-28	151	18	are	be	AUX
bptjm-28	151	19	chimeric	chimeric	ADJ
bptjm-28	151	20	receptors	receptor	NOUN
bptjm-28	151	21	of	of	ADP
bptjm-28	151	22	natural	natural	ADJ
bptjm-28	151	23	aav	aav	NOUN
bptjm-28	151	24	serotypes	serotype	NOUN
bptjm-28	151	25	.	.	PUNCT
bptjm-28	152	1	a	a	DET
bptjm-28	152	2	study	study	NOUN
bptjm-28	152	3	by	by	ADP
bptjm-28	152	4	ran	run	VERB
bptjm-28	152	5	et	et	PROPN
bptjm-28	152	6	.	.	PUNCT
bptjm-28	153	1	al	al	PROPN
bptjm-28	153	2	.	.	PROPN
bptjm-28	153	3	(	(	PUNCT
bptjm-28	153	4	2020	2020	NUM
bptjm-28	153	5	)	)	PUNCT
bptjm-28	153	6	showed	show	VERB
bptjm-28	153	7	that	that	SCONJ
bptjm-28	153	8	site	site	NOUN
bptjm-28	153	9	-	-	PUNCT
bptjm-28	153	10	directed	direct	VERB
bptjm-28	153	11	mutagenesis	mutagenesis	NOUN
bptjm-28	153	12	(	(	PUNCT
bptjm-28	153	13	raav	raav	NOUN
bptjm-28	153	14	-	-	PUNCT
bptjm-28	153	15	dj	dj	NOUN
bptjm-28	153	16	-	-	PUNCT
bptjm-28	153	17	s269	s269	NOUN
bptjm-28	153	18	t	t	PROPN
bptjm-28	153	19	)	)	PUNCT
bptjm-28	153	20	yielded	yield	VERB
bptjm-28	153	21	higher	high	ADJ
bptjm-28	153	22	transduction	transduction	NOUN
bptjm-28	153	23	e	e	NOUN
bptjm-28	153	24	�	�	NOUN
bptjm-28	153	25	ciency	ciency	NOUN
bptjm-28	153	26	compared	compare	VERB
bptjm-28	153	27	to	to	ADP
bptjm-28	153	28	wild	wild	ADJ
bptjm-28	153	29	-	-	PUNCT
bptjm-28	153	30	type	type	NOUN
bptjm-28	153	31	aav	aav	NOUN
bptjm-28	153	32	vectors	vector	NOUN
bptjm-28	153	33	,	,	PUNCT
bptjm-28	153	34	likely	likely	ADJ
bptjm-28	153	35	due	due	ADP
bptjm-28	153	36	to	to	ADP
bptjm-28	153	37	evasion	evasion	NOUN
bptjm-28	153	38	of	of	ADP
bptjm-28	153	39	the	the	DET
bptjm-28	153	40	host	host	NOUN
bptjm-28	153	41	immune	immune	PROPN
bptjm-28	153	42	response27	response27	PROPN
bptjm-28	153	43	.	.	PUNCT
bptjm-28	154	1	the	the	DET
bptjm-28	154	2	second	second	ADJ
bptjm-28	154	3	method	method	NOUN
bptjm-28	154	4	of	of	ADP
bptjm-28	154	5	re	re	NOUN
bptjm-28	154	6	�	�	PROPN
bptjm-28	154	7	ning	ne	VERB
bptjm-28	154	8	the	the	DET
bptjm-28	154	9	aav	aav	PROPN
bptjm-28	154	10	vector	vector	NOUN
bptjm-28	154	11	for	for	ADP
bptjm-28	154	12	administration	administration	NOUN
bptjm-28	154	13	is	be	AUX
bptjm-28	154	14	the	the	DET
bptjm-28	154	15	use	use	NOUN
bptjm-28	154	16	of	of	ADP
bptjm-28	154	17	directed	direct	VERB
bptjm-28	154	18	evolution28	evolution28	NOUN
bptjm-28	154	19	,	,	PUNCT
bptjm-28	154	20	where	where	SCONJ
bptjm-28	154	21	a	a	DET
bptjm-28	154	22	wild	wild	ADJ
bptjm-28	154	23	-	-	PUNCT
bptjm-28	154	24	type	type	NOUN
bptjm-28	154	25	aav	aav	NOUN
bptjm-28	154	26	vector	vector	NOUN
bptjm-28	154	27	is	be	AUX
bptjm-28	154	28	used	use	VERB
bptjm-28	154	29	to	to	PART
bptjm-28	154	30	generate	generate	VERB
bptjm-28	154	31	large	large	ADJ
bptjm-28	154	32	mutant	mutant	ADJ
bptjm-28	154	33	capsid	capsid	NOUN
bptjm-28	154	34	libraries	library	NOUN
bptjm-28	154	35	and	and	CCONJ
bptjm-28	154	36	aav2	aav2	PROPN
bptjm-28	154	37	variants	variant	NOUN
bptjm-28	154	38	with	with	ADP
bptjm-28	154	39	enhanced	enhanced	ADJ
bptjm-28	154	40	properties	property	NOUN
bptjm-28	154	41	,	,	PUNCT
bptjm-28	154	42	such	such	ADJ
bptjm-28	154	43	as	as	ADP
bptjm-28	154	44	immune	immune	ADJ
bptjm-28	154	45	evasion	evasion	NOUN
bptjm-28	154	46	,	,	PUNCT
bptjm-28	154	47	non	non	ADJ
bptjm-28	154	48	-	-	NOUN
bptjm-28	154	49	infection	infection	NOUN
bptjm-28	154	50	of	of	ADP
bptjm-28	154	51	resistant	resistant	ADJ
bptjm-28	154	52	cell	cell	NOUN
bptjm-28	154	53	types	type	NOUN
bptjm-28	154	54	,	,	PUNCT
bptjm-28	154	55	and	and	CCONJ
bptjm-28	154	56	tissue	tissue	NOUN
bptjm-28	154	57	transport	transport	NOUN
bptjm-28	154	58	.	.	PUNCT
bptjm-28	155	1	inhibitors	inhibitor	NOUN
bptjm-28	155	2	the	the	DET
bptjm-28	155	3	immune	immune	ADJ
bptjm-28	155	4	system	system	NOUN
bptjm-28	155	5	develops	develop	VERB
bptjm-28	155	6	antibodies	antibody	NOUN
bptjm-28	155	7	to	to	PART
bptjm-28	155	8	defend	defend	VERB
bptjm-28	155	9	against	against	ADP
bptjm-28	155	10	foreign	foreign	ADJ
bptjm-28	155	11	agents	agent	NOUN
bptjm-28	155	12	.	.	PUNCT
bptjm-28	156	1	patients	patient	NOUN
bptjm-28	156	2	with	with	ADP
bptjm-28	156	3	hemophilia	hemophilia	NOUN
bptjm-28	156	4	sometimes	sometimes	ADV
bptjm-28	156	5	develop	develop	VERB
bptjm-28	156	6	antibodies	antibody	NOUN
bptjm-28	156	7	to	to	PART
bptjm-28	156	8	fviii	fviii	VERB
bptjm-28	156	9	in	in	ADP
bptjm-28	156	10	response	response	NOUN
bptjm-28	156	11	to	to	ADP
bptjm-28	156	12	treatments	treatment	NOUN
bptjm-28	156	13	and	and	CCONJ
bptjm-28	156	14	medication	medication	NOUN
bptjm-28	156	15	.	.	PUNCT
bptjm-28	157	1	polyclonal	polyclonal	ADJ
bptjm-28	157	2	high	high	ADJ
bptjm-28	157	3	-	-	PUNCT
bptjm-28	157	4	a	a	DET
bptjm-28	157	5	�	�	PROPN
bptjm-28	157	6	nity	nity	NOUN
bptjm-28	157	7	berkeley	berkeley	PROPN
bptjm-28	157	8	pharma	pharma	PROPN
bptjm-28	157	9	tech	tech	NOUN
bptjm-28	157	10	journal	journal	NOUN
bptjm-28	157	11	of	of	ADP
bptjm-28	157	12	medicine	medicine	NOUN
bptjm-28	157	13	|	|	ADV
bptjm-28	157	14	130	130	NUM
bptjm-28	157	15	immunoglobulin	immunoglobulin	NOUN
bptjm-28	157	16	g	g	PROPN
bptjm-28	157	17	(	(	PUNCT
bptjm-28	157	18	igg	igg	PROPN
bptjm-28	157	19	)	)	PUNCT
bptjm-28	157	20	,	,	PUNCT
bptjm-28	157	21	or	or	CCONJ
bptjm-28	157	22	an	an	DET
bptjm-28	157	23	inhibitor	inhibitor	NOUN
bptjm-28	157	24	,	,	PUNCT
bptjm-28	157	25	prohibits	prohibit	VERB
bptjm-28	157	26	clotting	clot	VERB
bptjm-28	157	27	factor	factor	NOUN
bptjm-28	157	28	activity	activity	NOUN
bptjm-28	157	29	that	that	PRON
bptjm-28	157	30	further	far	ADV
bptjm-28	157	31	promotes	promote	VERB
bptjm-28	157	32	bleeding	bleed	VERB
bptjm-28	157	33	without	without	ADP
bptjm-28	157	34	clot	clot	NOUN
bptjm-28	157	35	formation	formation	NOUN
bptjm-28	157	36	.	.	PUNCT
bptjm-28	158	1	type	type	NOUN
bptjm-28	158	2	i	i	PRON
bptjm-28	158	3	and	and	CCONJ
bptjm-28	158	4	type	type	PROPN
bptjm-28	158	5	ii	ii	PROPN
bptjm-28	158	6	inhibitors	inhibitor	NOUN
bptjm-28	158	7	vary	vary	VERB
bptjm-28	158	8	based	base	VERB
bptjm-28	158	9	upon	upon	SCONJ
bptjm-28	158	10	the	the	DET
bptjm-28	158	11	extent	extent	NOUN
bptjm-28	158	12	of	of	ADP
bptjm-28	158	13	inhibition	inhibition	NOUN
bptjm-28	158	14	of	of	ADP
bptjm-28	158	15	clotting	clot	VERB
bptjm-28	158	16	factors	factor	NOUN
bptjm-28	158	17	.	.	PUNCT
bptjm-28	159	1	the	the	DET
bptjm-28	159	2	development	development	NOUN
bptjm-28	159	3	of	of	ADP
bptjm-28	159	4	inhibitors	inhibitor	NOUN
bptjm-28	159	5	is	be	AUX
bptjm-28	159	6	a	a	DET
bptjm-28	159	7	widely	widely	ADV
bptjm-28	159	8	understood	understand	VERB
bptjm-28	159	9	phenomenon	phenomenon	NOUN
bptjm-28	159	10	that	that	PRON
bptjm-28	159	11	continues	continue	VERB
bptjm-28	159	12	to	to	PART
bptjm-28	159	13	burden	burden	VERB
bptjm-28	159	14	treatment	treatment	NOUN
bptjm-28	159	15	e	e	NOUN
bptjm-28	159	16	�	�	NOUN
bptjm-28	159	17	ciency	ciency	NOUN
bptjm-28	159	18	.	.	PUNCT
bptjm-28	160	1	its	its	PRON
bptjm-28	160	2	e	e	NOUN
bptjm-28	160	3	�	�	PROPN
bptjm-28	160	4	ects	ect	NOUN
bptjm-28	160	5	are	be	AUX
bptjm-28	160	6	being	be	AUX
bptjm-28	160	7	studied	study	VERB
bptjm-28	160	8	through	through	ADP
bptjm-28	160	9	both	both	CCONJ
bptjm-28	160	10	genetic	genetic	ADJ
bptjm-28	160	11	and	and	CCONJ
bptjm-28	160	12	environmental	environmental	ADJ
bptjm-28	160	13	factors	factor	NOUN
bptjm-28	160	14	that	that	PRON
bptjm-28	160	15	contribute	contribute	VERB
bptjm-28	160	16	to	to	ADP
bptjm-28	160	17	formation	formation	NOUN
bptjm-28	160	18	.	.	PUNCT
bptjm-28	161	1	the	the	DET
bptjm-28	161	2	detection	detection	NOUN
bptjm-28	161	3	and	and	CCONJ
bptjm-28	161	4	quanti	quanti	PROPN
bptjm-28	161	5	�	�	PROPN
bptjm-28	161	6	cation	cation	NOUN
bptjm-28	161	7	of	of	ADP
bptjm-28	161	8	fviii	fviii	NOUN
bptjm-28	161	9	inhibitors	inhibitor	NOUN
bptjm-28	161	10	include	include	VERB
bptjm-28	161	11	the	the	DET
bptjm-28	161	12	bethesda	bethesda	NOUN
bptjm-28	161	13	assay	assay	VERB
bptjm-28	161	14	and	and	CCONJ
bptjm-28	161	15	the	the	DET
bptjm-28	161	16	nijmegen	nijmegen	PROPN
bptjm-28	161	17	-	-	PUNCT
bptjm-28	161	18	modi	modi	PROPN
bptjm-28	161	19	�	�	PROPN
bptjm-28	161	20	ed	ed	PROPN
bptjm-28	161	21	bethsda	bethsda	NOUN
bptjm-28	161	22	assay29	assay29	PROPN
bptjm-28	161	23	,	,	PUNCT
bptjm-28	161	24	30	30	NUM
bptjm-28	161	25	.	.	PUNCT
bptjm-28	162	1	inhibitor	inhibitor	NOUN
bptjm-28	162	2	formation	formation	NOUN
bptjm-28	162	3	contains	contain	VERB
bptjm-28	162	4	treatment	treatment	NOUN
bptjm-28	162	5	-	-	PUNCT
bptjm-28	162	6	related	relate	VERB
bptjm-28	162	7	risk	risk	NOUN
bptjm-28	162	8	factors	factor	NOUN
bptjm-28	162	9	that	that	PRON
bptjm-28	162	10	include	include	VERB
bptjm-28	162	11	age	age	NOUN
bptjm-28	162	12	and	and	CCONJ
bptjm-28	162	13	intensity	intensity	NOUN
bptjm-28	162	14	at	at	ADP
bptjm-28	162	15	�	�	NOUN
bptjm-28	162	16	rst	rst	PROPN
bptjm-28	162	17	exposure	exposure	NOUN
bptjm-28	162	18	,	,	PUNCT
bptjm-28	162	19	prophylaxis	prophylaxis	NOUN
bptjm-28	162	20	,	,	PUNCT
bptjm-28	162	21	and	and	CCONJ
bptjm-28	162	22	the	the	DET
bptjm-28	162	23	type	type	NOUN
bptjm-28	162	24	of	of	ADP
bptjm-28	162	25	treatment	treatment	NOUN
bptjm-28	162	26	(	(	PUNCT
bptjm-28	162	27	recombinant	recombinant	ADJ
bptjm-28	162	28	or	or	CCONJ
bptjm-28	162	29	plasma	plasma	NOUN
bptjm-28	162	30	derived	derive	VERB
bptjm-28	162	31	)	)	PUNCT
bptjm-28	162	32	.	.	PUNCT
bptjm-28	163	1	the	the	DET
bptjm-28	163	2	e	e	X
bptjm-28	163	3	�	�	PROPN
bptjm-28	163	4	ect	ect	NOUN
bptjm-28	163	5	of	of	ADP
bptjm-28	163	6	age	age	NOUN
bptjm-28	163	7	was	be	AUX
bptjm-28	163	8	observed	observe	VERB
bptjm-28	163	9	in	in	ADP
bptjm-28	163	10	a	a	DET
bptjm-28	163	11	population	population	NOUN
bptjm-28	163	12	of	of	ADP
bptjm-28	163	13	hemophilia	hemophilia	NOUN
bptjm-28	163	14	a	a	DET
bptjm-28	163	15	patients	patient	NOUN
bptjm-28	163	16	with	with	ADP
bptjm-28	163	17	the	the	DET
bptjm-28	163	18	onset	onset	NOUN
bptjm-28	163	19	of	of	ADP
bptjm-28	163	20	fviii	fviii	NOUN
bptjm-28	163	21	therapy	therapy	NOUN
bptjm-28	163	22	within	within	ADP
bptjm-28	163	23	1	1	NUM
bptjm-28	163	24	year	year	NOUN
bptjm-28	163	25	of	of	ADP
bptjm-28	163	26	age	age	NOUN
bptjm-28	163	27	.	.	PUNCT
bptjm-28	164	1	it	it	PRON
bptjm-28	164	2	was	be	AUX
bptjm-28	164	3	found	find	VERB
bptjm-28	164	4	that	that	SCONJ
bptjm-28	164	5	patients	patient	NOUN
bptjm-28	164	6	that	that	PRON
bptjm-28	164	7	started	start	VERB
bptjm-28	164	8	therapy	therapy	NOUN
bptjm-28	164	9	earlier	early	ADV
bptjm-28	164	10	in	in	ADP
bptjm-28	164	11	life	life	NOUN
bptjm-28	164	12	are	be	AUX
bptjm-28	164	13	more	more	ADV
bptjm-28	164	14	prone	prone	ADJ
bptjm-28	164	15	to	to	ADP
bptjm-28	164	16	inhibitor	inhibitor	NOUN
bptjm-28	164	17	development	development	NOUN
bptjm-28	164	18	.	.	PUNCT
bptjm-28	165	1	however	however	ADV
bptjm-28	165	2	,	,	PUNCT
bptjm-28	165	3	there	there	PRON
bptjm-28	165	4	is	be	VERB
bptjm-28	165	5	a	a	DET
bptjm-28	165	6	lack	lack	NOUN
bptjm-28	165	7	of	of	ADP
bptjm-28	165	8	knowledge	knowledge	NOUN
bptjm-28	165	9	on	on	ADP
bptjm-28	165	10	the	the	DET
bptjm-28	165	11	e	e	PROPN
bptjm-28	165	12	�	�	PROPN
bptjm-28	165	13	ects	ect	NOUN
bptjm-28	165	14	of	of	ADP
bptjm-28	165	15	delayed	delay	VERB
bptjm-28	165	16	treatment	treatment	NOUN
bptjm-28	165	17	initiation	initiation	NOUN
bptjm-28	165	18	due	due	ADP
bptjm-28	165	19	to	to	ADP
bptjm-28	165	20	the	the	DET
bptjm-28	165	21	tendency	tendency	NOUN
bptjm-28	165	22	for	for	SCONJ
bptjm-28	165	23	patients	patient	NOUN
bptjm-28	165	24	to	to	PART
bptjm-28	165	25	require	require	VERB
bptjm-28	165	26	therapy	therapy	NOUN
bptjm-28	165	27	in	in	ADP
bptjm-28	165	28	early	early	ADJ
bptjm-28	165	29	age31	age31	NOUN
bptjm-28	165	30	.	.	PUNCT
bptjm-28	166	1	the	the	DET
bptjm-28	166	2	intensity	intensity	NOUN
bptjm-28	166	3	of	of	ADP
bptjm-28	166	4	treatment	treatment	NOUN
bptjm-28	166	5	measured	measure	VERB
bptjm-28	166	6	by	by	ADP
bptjm-28	166	7	scheduled	schedule	VERB
bptjm-28	166	8	gaps	gap	NOUN
bptjm-28	166	9	between	between	ADP
bptjm-28	166	10	series	series	NOUN
bptjm-28	166	11	of	of	ADP
bptjm-28	166	12	exposures	exposure	NOUN
bptjm-28	166	13	showed	show	VERB
bptjm-28	166	14	that	that	SCONJ
bptjm-28	166	15	shorter	short	ADJ
bptjm-28	166	16	gaps	gap	NOUN
bptjm-28	166	17	were	be	AUX
bptjm-28	166	18	re	re	VERB
bptjm-28	166	19	�	�	NOUN
bptjm-28	166	20	ective	ective	NOUN
bptjm-28	166	21	of	of	ADP
bptjm-28	166	22	increased	increase	VERB
bptjm-28	166	23	risk	risk	NOUN
bptjm-28	166	24	of	of	ADP
bptjm-28	166	25	inhibitor	inhibitor	NOUN
bptjm-28	166	26	development	development	NOUN
bptjm-28	166	27	.	.	PUNCT
bptjm-28	167	1	prophylaxis	prophylaxis	PROPN
bptjm-28	167	2	is	be	AUX
bptjm-28	167	3	a	a	DET
bptjm-28	167	4	treatment	treatment	NOUN
bptjm-28	167	5	that	that	PRON
bptjm-28	167	6	exposes	expose	VERB
bptjm-28	167	7	patients	patient	NOUN
bptjm-28	167	8	to	to	ADP
bptjm-28	167	9	antigens	antigen	NOUN
bptjm-28	167	10	to	to	PART
bptjm-28	167	11	minimize	minimize	VERB
bptjm-28	167	12	the	the	DET
bptjm-28	167	13	possibility	possibility	NOUN
bptjm-28	167	14	of	of	ADP
bptjm-28	167	15	immune	immune	ADJ
bptjm-28	167	16	response	response	NOUN
bptjm-28	167	17	to	to	ADP
bptjm-28	167	18	additional	additional	ADJ
bptjm-28	167	19	treatment	treatment	NOUN
bptjm-28	167	20	.	.	PUNCT
bptjm-28	168	1	it	it	PRON
bptjm-28	168	2	was	be	AUX
bptjm-28	168	3	found	find	VERB
bptjm-28	168	4	that	that	SCONJ
bptjm-28	168	5	prophylaxis	prophylaxis	NOUN
bptjm-28	168	6	reduces	reduce	VERB
bptjm-28	168	7	probability	probability	NOUN
bptjm-28	168	8	for	for	ADP
bptjm-28	168	9	the	the	DET
bptjm-28	168	10	development	development	NOUN
bptjm-28	168	11	of	of	ADP
bptjm-28	168	12	inhibitors32	inhibitors32	NOUN
bptjm-28	168	13	.	.	PUNCT
bptjm-28	169	1	pre	pre	VERB
bptjm-28	169	2	-	-	ADJ
bptjm-28	169	3	existing	exist	VERB
bptjm-28	169	4	immunity	immunity	NOUN
bptjm-28	169	5	from	from	ADP
bptjm-28	169	6	neutralizing	neutralize	VERB
bptjm-28	169	7	antibodies	antibody	NOUN
bptjm-28	169	8	or	or	CCONJ
bptjm-28	169	9	inhibitors	inhibitor	NOUN
bptjm-28	169	10	can	can	AUX
bptjm-28	169	11	be	be	AUX
bptjm-28	169	12	overcome	overcome	VERB
bptjm-28	169	13	by	by	ADP
bptjm-28	169	14	creating	create	VERB
bptjm-28	169	15	alternate	alternate	ADJ
bptjm-28	169	16	aav	aav	NOUN
bptjm-28	169	17	serotypes33	serotypes33	NOUN
bptjm-28	169	18	.	.	PUNCT
bptjm-28	170	1	the	the	DET
bptjm-28	170	2	success	success	NOUN
bptjm-28	170	3	of	of	ADP
bptjm-28	170	4	serotype	serotype	NOUN
bptjm-28	170	5	-	-	PUNCT
bptjm-28	170	6	switching	switching	NOUN
bptjm-28	170	7	is	be	AUX
bptjm-28	170	8	contingent	contingent	ADJ
bptjm-28	170	9	on	on	ADP
bptjm-28	170	10	tropism	tropism	ADJ
bptjm-28	170	11	similarities	similarity	NOUN
bptjm-28	170	12	of	of	ADP
bptjm-28	170	13	the	the	DET
bptjm-28	170	14	new	new	ADJ
bptjm-28	170	15	serotype	serotype	NOUN
bptjm-28	170	16	and	and	CCONJ
bptjm-28	170	17	the	the	DET
bptjm-28	170	18	lack	lack	NOUN
bptjm-28	170	19	of	of	ADP
bptjm-28	170	20	crossreactivity	crossreactivity	NOUN
bptjm-28	170	21	between	between	ADP
bptjm-28	170	22	the	the	DET
bptjm-28	170	23	serotypes	serotype	NOUN
bptjm-28	170	24	.	.	PUNCT
bptjm-28	171	1	the	the	DET
bptjm-28	171	2	criteria	criterion	NOUN
bptjm-28	171	3	has	have	AUX
bptjm-28	171	4	been	be	AUX
bptjm-28	171	5	proven	prove	VERB
bptjm-28	171	6	di	di	NOUN
bptjm-28	171	7	�	�	PROPN
bptjm-28	171	8	cult	cult	NOUN
bptjm-28	171	9	upon	upon	SCONJ
bptjm-28	171	10	the	the	DET
bptjm-28	171	11	high	high	ADJ
bptjm-28	171	12	rate	rate	NOUN
bptjm-28	171	13	of	of	ADP
bptjm-28	171	14	crossreactivity	crossreactivity	NOUN
bptjm-28	171	15	in	in	ADP
bptjm-28	171	16	trials	trial	NOUN
bptjm-28	171	17	that	that	PRON
bptjm-28	171	18	prohibit	prohibit	VERB
bptjm-28	171	19	successful	successful	ADJ
bptjm-28	171	20	e	e	NOUN
bptjm-28	171	21	�	�	NOUN
bptjm-28	171	22	orts34	orts34	ADJ
bptjm-28	171	23	.	.	PUNCT
bptjm-28	172	1	immune	immune	ADJ
bptjm-28	172	2	tolerance	tolerance	NOUN
bptjm-28	172	3	induction	induction	NOUN
bptjm-28	172	4	(	(	PUNCT
bptjm-28	172	5	iti	iti	PROPN
bptjm-28	172	6	)	)	PUNCT
bptjm-28	172	7	is	be	AUX
bptjm-28	172	8	currently	currently	ADV
bptjm-28	172	9	the	the	DET
bptjm-28	172	10	only	only	ADJ
bptjm-28	172	11	proven	prove	VERB
bptjm-28	172	12	treatment	treatment	NOUN
bptjm-28	172	13	to	to	PART
bptjm-28	172	14	eliminate	eliminate	VERB
bptjm-28	172	15	inhibitor	inhibitor	NOUN
bptjm-28	172	16	development	development	NOUN
bptjm-28	172	17	.	.	PUNCT
bptjm-28	173	1	despite	despite	SCONJ
bptjm-28	173	2	a	a	DET
bptjm-28	173	3	60	60	NUM
bptjm-28	173	4	-	-	SYM
bptjm-28	173	5	80	80	NUM
bptjm-28	173	6	%	%	NOUN
bptjm-28	173	7	success	success	NOUN
bptjm-28	173	8	rate	rate	NOUN
bptjm-28	173	9	,	,	PUNCT
bptjm-28	173	10	the	the	DET
bptjm-28	173	11	high	high	ADJ
bptjm-28	173	12	cost	cost	NOUN
bptjm-28	173	13	creates	create	VERB
bptjm-28	173	14	�	�	PROPN
bptjm-28	173	15	nancial	nancial	PROPN
bptjm-28	173	16	di	di	NOUN
bptjm-28	173	17	�	�	NOUN
bptjm-28	173	18	culties	cultie	NOUN
bptjm-28	173	19	for	for	ADP
bptjm-28	173	20	patients	patient	NOUN
bptjm-28	173	21	in	in	ADP
bptjm-28	173	22	need	need	NOUN
bptjm-28	173	23	of	of	ADP
bptjm-28	173	24	this	this	DET
bptjm-28	173	25	treatment	treatment	NOUN
bptjm-28	173	26	.	.	PUNCT
bptjm-28	174	1	there	there	PRON
bptjm-28	174	2	is	be	VERB
bptjm-28	174	3	potential	potential	ADJ
bptjm-28	174	4	for	for	SCONJ
bptjm-28	174	5	gene	gene	NOUN
bptjm-28	174	6	therapy	therapy	NOUN
bptjm-28	174	7	to	to	PART
bptjm-28	174	8	serve	serve	VERB
bptjm-28	174	9	as	as	ADP
bptjm-28	174	10	an	an	DET
bptjm-28	174	11	iti	iti	NOUN
bptjm-28	174	12	-	-	PUNCT
bptjm-28	174	13	type	type	NOUN
bptjm-28	174	14	therapy	therapy	NOUN
bptjm-28	174	15	to	to	PART
bptjm-28	174	16	eradicate	eradicate	VERB
bptjm-28	174	17	the	the	DET
bptjm-28	174	18	need	need	NOUN
bptjm-28	174	19	for	for	ADP
bptjm-28	174	20	iti	iti	PROPN
bptjm-28	174	21	due	due	ADP
bptjm-28	174	22	to	to	ADP
bptjm-28	174	23	the	the	DET
bptjm-28	174	24	continual	continual	ADJ
bptjm-28	174	25	production	production	NOUN
bptjm-28	174	26	of	of	ADP
bptjm-28	174	27	clotting	clot	VERB
bptjm-28	174	28	factors35	factors35	NOUN
bptjm-28	174	29	.	.	PUNCT
bptjm-28	175	1	berkeley	berkeley	PROPN
bptjm-28	175	2	pharma	pharma	PROPN
bptjm-28	175	3	tech	tech	PROPN
bptjm-28	175	4	journal	journal	NOUN
bptjm-28	175	5	of	of	ADP
bptjm-28	175	6	medicine	medicine	NOUN
bptjm-28	175	7	|	|	ADV
bptjm-28	175	8	131	131	NUM
bptjm-28	175	9	alternatives	alternative	NOUN
bptjm-28	175	10	to	to	ADP
bptjm-28	175	11	gene	gene	NOUN
bptjm-28	175	12	therapies	therapy	NOUN
bptjm-28	175	13	while	while	SCONJ
bptjm-28	175	14	aav	aav	NOUN
bptjm-28	175	15	-	-	PUNCT
bptjm-28	175	16	gene	gene	NOUN
bptjm-28	175	17	therapy	therapy	NOUN
bptjm-28	175	18	has	have	AUX
bptjm-28	175	19	made	make	VERB
bptjm-28	175	20	the	the	DET
bptjm-28	175	21	most	most	ADJ
bptjm-28	175	22	progress	progress	NOUN
bptjm-28	175	23	in	in	ADP
bptjm-28	175	24	the	the	DET
bptjm-28	175	25	future	future	ADJ
bptjm-28	175	26	treatment	treatment	NOUN
bptjm-28	175	27	for	for	ADP
bptjm-28	175	28	hemophilia	hemophilia	NOUN
bptjm-28	175	29	,	,	PUNCT
bptjm-28	175	30	new	new	ADJ
bptjm-28	175	31	research	research	NOUN
bptjm-28	175	32	has	have	AUX
bptjm-28	175	33	come	come	VERB
bptjm-28	175	34	out	out	ADP
bptjm-28	175	35	in	in	ADP
bptjm-28	175	36	an	an	DET
bptjm-28	175	37	e	e	NOUN
bptjm-28	175	38	�	�	NOUN
bptjm-28	175	39	ort	ort	NOUN
bptjm-28	175	40	to	to	PART
bptjm-28	175	41	bypass	bypass	VERB
bptjm-28	175	42	the	the	DET
bptjm-28	175	43	concerns	concern	NOUN
bptjm-28	175	44	of	of	ADP
bptjm-28	175	45	aav	aav	NOUN
bptjm-28	175	46	explained	explain	VERB
bptjm-28	175	47	previously	previously	ADV
bptjm-28	175	48	.	.	PUNCT
bptjm-28	176	1	a	a	DET
bptjm-28	176	2	recent	recent	ADJ
bptjm-28	176	3	study	study	NOUN
bptjm-28	176	4	published	publish	VERB
bptjm-28	176	5	by	by	ADP
bptjm-28	176	6	song	song	NOUN
bptjm-28	176	7	et	et	PROPN
bptjm-28	176	8	.	.	PUNCT
bptjm-28	177	1	al	al	PROPN
bptjm-28	177	2	.	.	PROPN
bptjm-28	178	1	(	(	PUNCT
bptjm-28	178	2	2022	2022	NUM
bptjm-28	178	3	)	)	PUNCT
bptjm-28	178	4	shows	show	VERB
bptjm-28	178	5	a	a	DET
bptjm-28	178	6	promising	promising	ADJ
bptjm-28	178	7	alternative	alternative	NOUN
bptjm-28	178	8	to	to	ADP
bptjm-28	178	9	aav	aav	NOUN
bptjm-28	178	10	gene	gene	NOUN
bptjm-28	178	11	therapy	therapy	NOUN
bptjm-28	178	12	known	know	VERB
bptjm-28	178	13	as	as	ADP
bptjm-28	178	14	ultrasound	ultrasound	NOUN
bptjm-28	178	15	mediated	mediate	VERB
bptjm-28	178	16	gene	gene	NOUN
bptjm-28	178	17	delivery	delivery	NOUN
bptjm-28	178	18	(	(	PUNCT
bptjm-28	178	19	umgd	umgd	PROPN
bptjm-28	178	20	)	)	PUNCT
bptjm-28	178	21	,	,	PUNCT
bptjm-28	178	22	where	where	SCONJ
bptjm-28	178	23	the	the	DET
bptjm-28	178	24	plasmid	plasmid	NOUN
bptjm-28	178	25	containing	contain	VERB
bptjm-28	178	26	the	the	DET
bptjm-28	178	27	functional	functional	ADJ
bptjm-28	178	28	factor	factor	NOUN
bptjm-28	178	29	viii	viii	NOUN
bptjm-28	178	30	gene	gene	NOUN
bptjm-28	178	31	is	be	AUX
bptjm-28	178	32	injected	inject	VERB
bptjm-28	178	33	directly	directly	ADV
bptjm-28	178	34	into	into	ADP
bptjm-28	178	35	hemophilia	hemophilia	NOUN
bptjm-28	178	36	a	a	DET
bptjm-28	178	37	patients	patient	NOUN
bptjm-28	178	38	.	.	PUNCT
bptjm-28	179	1	umgd	umgd	PROPN
bptjm-28	179	2	of	of	ADP
bptjm-28	179	3	reporter	reporter	NOUN
bptjm-28	179	4	plasmids	plasmid	NOUN
bptjm-28	179	5	targeting	target	VERB
bptjm-28	179	6	mice	mouse	NOUN
bptjm-28	179	7	livers	liver	NOUN
bptjm-28	179	8	achieved	achieve	VERB
bptjm-28	179	9	high	high	ADJ
bptjm-28	179	10	levels	level	NOUN
bptjm-28	179	11	of	of	ADP
bptjm-28	179	12	transgene	transgene	ADJ
bptjm-28	179	13	expression	expression	NOUN
bptjm-28	179	14	predominantly	predominantly	ADV
bptjm-28	179	15	in	in	ADP
bptjm-28	179	16	hepatocytes	hepatocyte	NOUN
bptjm-28	179	17	,	,	PUNCT
bptjm-28	179	18	while	while	SCONJ
bptjm-28	179	19	maintaining	maintain	VERB
bptjm-28	179	20	minimal	minimal	ADJ
bptjm-28	179	21	transaminase	transaminase	NOUN
bptjm-28	179	22	levels	level	NOUN
bptjm-28	179	23	following	follow	VERB
bptjm-28	179	24	injection37	injection37	NOUN
bptjm-28	179	25	.	.	PUNCT
bptjm-28	180	1	however	however	ADV
bptjm-28	180	2	,	,	PUNCT
bptjm-28	180	3	these	these	DET
bptjm-28	180	4	results	result	NOUN
bptjm-28	180	5	have	have	VERB
bptjm-28	180	6	yet	yet	ADV
bptjm-28	180	7	to	to	PART
bptjm-28	180	8	be	be	AUX
bptjm-28	180	9	proven	prove	VERB
bptjm-28	180	10	in	in	ADP
bptjm-28	180	11	human	human	ADJ
bptjm-28	180	12	clinical	clinical	ADJ
bptjm-28	180	13	trials	trial	NOUN
bptjm-28	180	14	and	and	CCONJ
bptjm-28	180	15	are	be	AUX
bptjm-28	180	16	still	still	ADV
bptjm-28	180	17	years	year	NOUN
bptjm-28	180	18	away	away	ADV
bptjm-28	180	19	.	.	PUNCT
bptjm-28	181	1	similar	similar	ADJ
bptjm-28	181	2	to	to	ADP
bptjm-28	181	3	aav	aav	NOUN
bptjm-28	181	4	vectors	vector	NOUN
bptjm-28	181	5	,	,	PUNCT
bptjm-28	181	6	lentiviral	lentiviral	ADJ
bptjm-28	181	7	vectors	vector	NOUN
bptjm-28	181	8	do	do	AUX
bptjm-28	181	9	not	not	PART
bptjm-28	181	10	contain	contain	VERB
bptjm-28	181	11	viral	viral	ADJ
bptjm-28	181	12	genes	gene	NOUN
bptjm-28	181	13	and	and	CCONJ
bptjm-28	181	14	promote	promote	VERB
bptjm-28	181	15	long	long	ADJ
bptjm-28	181	16	-	-	PUNCT
bptjm-28	181	17	term	term	NOUN
bptjm-28	181	18	gene	gene	NOUN
bptjm-28	181	19	expression	expression	NOUN
bptjm-28	181	20	which	which	PRON
bptjm-28	181	21	make	make	VERB
bptjm-28	181	22	both	both	DET
bptjm-28	181	23	vectors	vector	NOUN
bptjm-28	181	24	strong	strong	ADJ
bptjm-28	181	25	candidates	candidate	NOUN
bptjm-28	181	26	for	for	ADP
bptjm-28	181	27	gene	gene	NOUN
bptjm-28	181	28	therapy	therapy	NOUN
bptjm-28	181	29	.	.	PUNCT
bptjm-28	182	1	despite	despite	SCONJ
bptjm-28	182	2	increased	increase	VERB
bptjm-28	182	3	stability	stability	NOUN
bptjm-28	182	4	upon	upon	SCONJ
bptjm-28	182	5	genomic	genomic	ADJ
bptjm-28	182	6	integration	integration	NOUN
bptjm-28	182	7	,	,	PUNCT
bptjm-28	182	8	lentiviral	lentiviral	ADJ
bptjm-28	182	9	vectors	vector	NOUN
bptjm-28	182	10	activate	activate	VERB
bptjm-28	182	11	the	the	DET
bptjm-28	182	12	innate	innate	ADJ
bptjm-28	182	13	immune	immune	ADJ
bptjm-28	182	14	response	response	NOUN
bptjm-28	182	15	to	to	PART
bptjm-28	182	16	limit	limit	VERB
bptjm-28	182	17	its	its	PRON
bptjm-28	182	18	capabilities	capability	NOUN
bptjm-28	182	19	in	in	ADP
bptjm-28	182	20	increasing	increase	VERB
bptjm-28	182	21	clotting	clot	VERB
bptjm-28	182	22	factor	factor	NOUN
bptjm-28	182	23	levels	level	NOUN
bptjm-28	182	24	.	.	PUNCT
bptjm-28	183	1	the	the	DET
bptjm-28	183	2	adaptive	adaptive	ADJ
bptjm-28	183	3	immune	immune	ADJ
bptjm-28	183	4	system	system	NOUN
bptjm-28	183	5	,	,	PUNCT
bptjm-28	183	6	however	however	ADV
bptjm-28	183	7	,	,	PUNCT
bptjm-28	183	8	is	be	AUX
bptjm-28	183	9	unresponsive	unresponsive	ADJ
bptjm-28	183	10	upon	upon	SCONJ
bptjm-28	183	11	cell	cell	NOUN
bptjm-28	183	12	transduction38	transduction38	NOUN
bptjm-28	183	13	.	.	PUNCT
bptjm-28	184	1	hemostatic	hemostatic	ADJ
bptjm-28	184	2	agents	agent	NOUN
bptjm-28	184	3	have	have	AUX
bptjm-28	184	4	been	be	AUX
bptjm-28	184	5	engineered	engineer	VERB
bptjm-28	184	6	to	to	PART
bptjm-28	184	7	overcome	overcome	VERB
bptjm-28	184	8	fviii	fviii	NOUN
bptjm-28	184	9	and	and	CCONJ
bptjm-28	184	10	fix	fix	NOUN
bptjm-28	184	11	activity	activity	NOUN
bptjm-28	184	12	in	in	ADP
bptjm-28	184	13	hemophilic	hemophilic	ADJ
bptjm-28	184	14	patients	patient	NOUN
bptjm-28	184	15	as	as	ADP
bptjm-28	184	16	an	an	DET
bptjm-28	184	17	alternate	alternate	ADJ
bptjm-28	184	18	protein	protein	NOUN
bptjm-28	184	19	therapy	therapy	NOUN
bptjm-28	184	20	.	.	PUNCT
bptjm-28	185	1	the	the	DET
bptjm-28	185	2	hyperactive	hyperactive	ADJ
bptjm-28	185	3	fviia	fviia	NOUN
bptjm-28	185	4	variant	variant	NOUN
bptjm-28	185	5	has	have	AUX
bptjm-28	185	6	undergone	undergo	VERB
bptjm-28	185	7	experimentation	experimentation	NOUN
bptjm-28	185	8	as	as	ADP
bptjm-28	185	9	a	a	DET
bptjm-28	185	10	transgene	transgene	NOUN
bptjm-28	185	11	for	for	ADP
bptjm-28	185	12	aav	aav	NOUN
bptjm-28	185	13	-	-	PUNCT
bptjm-28	185	14	based	base	VERB
bptjm-28	185	15	liver	liver	NOUN
bptjm-28	185	16	-	-	PUNCT
bptjm-28	185	17	directed	direct	VERB
bptjm-28	185	18	gene	gene	NOUN
bptjm-28	185	19	therapy	therapy	NOUN
bptjm-28	185	20	.	.	PUNCT
bptjm-28	186	1	this	this	PRON
bptjm-28	186	2	resulted	result	VERB
bptjm-28	186	3	in	in	ADP
bptjm-28	186	4	the	the	DET
bptjm-28	186	5	usage	usage	NOUN
bptjm-28	186	6	of	of	ADP
bptjm-28	186	7	a	a	DET
bptjm-28	186	8	lower	low	ADJ
bptjm-28	186	9	vector	vector	NOUN
bptjm-28	186	10	dose	dose	NOUN
bptjm-28	186	11	while	while	SCONJ
bptjm-28	186	12	maintaining	maintain	VERB
bptjm-28	186	13	a	a	DET
bptjm-28	186	14	similar	similar	ADJ
bptjm-28	186	15	response	response	NOUN
bptjm-28	186	16	to	to	ADP
bptjm-28	186	17	hemostatic	hemostatic	ADJ
bptjm-28	186	18	conditions	condition	NOUN
bptjm-28	186	19	.	.	PUNCT
bptjm-28	187	1	although	although	SCONJ
bptjm-28	187	2	clinical	clinical	ADJ
bptjm-28	187	3	trials	trial	NOUN
bptjm-28	187	4	have	have	AUX
bptjm-28	187	5	proceeded	proceed	VERB
bptjm-28	187	6	into	into	ADP
bptjm-28	187	7	late	late	ADJ
bptjm-28	187	8	stages	stage	NOUN
bptjm-28	187	9	,	,	PUNCT
bptjm-28	187	10	it	it	PRON
bptjm-28	187	11	has	have	AUX
bptjm-28	187	12	halted	halt	VERB
bptjm-28	187	13	due	due	ADJ
bptjm-28	187	14	to	to	ADP
bptjm-28	187	15	immunogenicity	immunogenicity	NOUN
bptjm-28	187	16	speculation	speculation	NOUN
bptjm-28	187	17	.	.	PUNCT
bptjm-28	188	1	if	if	SCONJ
bptjm-28	188	2	continued	continue	VERB
bptjm-28	188	3	in	in	ADP
bptjm-28	188	4	the	the	DET
bptjm-28	188	5	future	future	NOUN
bptjm-28	188	6	,	,	PUNCT
bptjm-28	188	7	the	the	DET
bptjm-28	188	8	fviia	fviia	ADJ
bptjm-28	188	9	transgene	transgene	NOUN
bptjm-28	188	10	may	may	AUX
bptjm-28	188	11	be	be	AUX
bptjm-28	188	12	able	able	ADJ
bptjm-28	188	13	to	to	PART
bptjm-28	188	14	lower	lower	VERB
bptjm-28	188	15	the	the	DET
bptjm-28	188	16	vector	vector	NOUN
bptjm-28	188	17	dose	dose	NOUN
bptjm-28	188	18	for	for	ADP
bptjm-28	188	19	patients	patient	NOUN
bptjm-28	188	20	.	.	PUNCT
bptjm-28	189	1	protein	protein	NOUN
bptjm-28	189	2	-	-	PUNCT
bptjm-28	189	3	engineered	engineer	VERB
bptjm-28	189	4	bypassing	bypassing	NOUN
bptjm-28	189	5	agents	agent	NOUN
bptjm-28	189	6	have	have	AUX
bptjm-28	189	7	prolonged	prolong	VERB
bptjm-28	189	8	the	the	DET
bptjm-28	189	9	half	half	ADJ
bptjm-28	189	10	-	-	PUNCT
bptjm-28	189	11	life	life	NOUN
bptjm-28	189	12	of	of	ADP
bptjm-28	189	13	coagulation	coagulation	NOUN
bptjm-28	189	14	factors	factor	NOUN
bptjm-28	189	15	downstream	downstream	ADV
bptjm-28	189	16	of	of	ADP
bptjm-28	189	17	clotting	clot	VERB
bptjm-28	189	18	factors	factor	NOUN
bptjm-28	189	19	that	that	PRON
bptjm-28	189	20	are	be	AUX
bptjm-28	189	21	designed	design	VERB
bptjm-28	189	22	to	to	PART
bptjm-28	189	23	resist	resist	VERB
bptjm-28	189	24	inactivation	inactivation	NOUN
bptjm-28	189	25	via	via	ADP
bptjm-28	189	26	conformational	conformational	ADJ
bptjm-28	189	27	changes	change	NOUN
bptjm-28	189	28	to	to	ADP
bptjm-28	189	29	protein	protein	NOUN
bptjm-28	189	30	structures	structure	NOUN
bptjm-28	189	31	.	.	PUNCT
bptjm-28	190	1	this	this	DET
bptjm-28	190	2	treatment	treatment	NOUN
bptjm-28	190	3	is	be	AUX
bptjm-28	190	4	undergoing	undergo	VERB
bptjm-28	190	5	early	early	ADJ
bptjm-28	190	6	-	-	PUNCT
bptjm-28	190	7	stage	stage	NOUN
bptjm-28	190	8	clinical	clinical	ADJ
bptjm-28	190	9	trials	trial	NOUN
bptjm-28	190	10	and	and	CCONJ
bptjm-28	190	11	has	have	AUX
bptjm-28	190	12	proven	prove	VERB
bptjm-28	190	13	e	e	NOUN
bptjm-28	190	14	�	�	NOUN
bptjm-28	190	15	cacy	cacy	NOUN
bptjm-28	190	16	as	as	ADP
bptjm-28	190	17	a	a	DET
bptjm-28	190	18	protein	protein	NOUN
bptjm-28	190	19	therapy	therapy	NOUN
bptjm-28	190	20	for	for	ADP
bptjm-28	190	21	acute	acute	PROPN
bptjm-28	190	22	hemorrhagic	hemorrhagic	PROPN
bptjm-28	190	23	conditions39	conditions39	PROPN
bptjm-28	190	24	.	.	PUNCT
bptjm-28	191	1	berkeley	berkeley	PROPN
bptjm-28	191	2	pharma	pharma	PROPN
bptjm-28	191	3	tech	tech	PROPN
bptjm-28	191	4	journal	journal	NOUN
bptjm-28	191	5	of	of	ADP
bptjm-28	191	6	medicine	medicine	NOUN
bptjm-28	191	7	|	|	ADV
bptjm-28	191	8	132	132	NUM
bptjm-28	191	9	table	table	NOUN
bptjm-28	191	10	1	1	NUM
bptjm-28	191	11	:	:	PUNCT
bptjm-28	191	12	comparison	comparison	NOUN
bptjm-28	191	13	between	between	ADP
bptjm-28	191	14	aav	aav	PROPN
bptjm-28	191	15	,	,	PUNCT
bptjm-28	191	16	lentivirus	lentivirus	NOUN
bptjm-28	191	17	,	,	PUNCT
bptjm-28	191	18	and	and	CCONJ
bptjm-28	191	19	adenovirus	adenovirus	NOUN
bptjm-28	191	20	vectors	vector	NOUN
bptjm-28	191	21	.	.	PUNCT
bptjm-28	192	1	inhibitors	inhibitor	NOUN
bptjm-28	192	2	additionally	additionally	ADV
bptjm-28	192	3	,	,	PUNCT
bptjm-28	192	4	there	there	PRON
bptjm-28	192	5	are	be	VERB
bptjm-28	192	6	structural	structural	ADJ
bptjm-28	192	7	,	,	PUNCT
bptjm-28	192	8	functional	functional	ADJ
bptjm-28	192	9	,	,	PUNCT
bptjm-28	192	10	and	and	CCONJ
bptjm-28	192	11	expression	expression	NOUN
bptjm-28	192	12	di	di	NOUN
bptjm-28	192	13	�	�	PROPN
bptjm-28	192	14	erences	erence	NOUN
bptjm-28	192	15	between	between	ADP
bptjm-28	192	16	the	the	DET
bptjm-28	192	17	aav	aav	PROPN
bptjm-28	192	18	vector	vector	NOUN
bptjm-28	192	19	,	,	PUNCT
bptjm-28	192	20	lentivirus	lentivirus	NOUN
bptjm-28	192	21	,	,	PUNCT
bptjm-28	192	22	and	and	CCONJ
bptjm-28	192	23	adenoviral	adenoviral	ADJ
bptjm-28	192	24	vectors	vector	NOUN
bptjm-28	192	25	to	to	PART
bptjm-28	192	26	account	account	VERB
bptjm-28	192	27	for	for	ADP
bptjm-28	192	28	.	.	PUNCT
bptjm-28	193	1	aav	aav	NOUN
bptjm-28	193	2	is	be	AUX
bptjm-28	193	3	a	a	DET
bptjm-28	193	4	smaller	small	ADJ
bptjm-28	193	5	vector	vector	NOUN
bptjm-28	193	6	consisting	consist	VERB
bptjm-28	193	7	of	of	ADP
bptjm-28	193	8	approximately	approximately	ADV
bptjm-28	193	9	25	25	NUM
bptjm-28	193	10	nm	nm	NOUN
bptjm-28	193	11	,	,	PUNCT
bptjm-28	193	12	whereas	whereas	SCONJ
bptjm-28	193	13	lentivirus	lentivirus	NOUN
bptjm-28	193	14	is	be	AUX
bptjm-28	193	15	80	80	NUM
bptjm-28	193	16	nm	nm	NOUN
bptjm-28	193	17	to	to	ADP
bptjm-28	193	18	120	120	NUM
bptjm-28	193	19	nm	nm	NOUN
bptjm-28	193	20	,	,	PUNCT
bptjm-28	193	21	and	and	CCONJ
bptjm-28	193	22	adenovector	adenovector	NOUN
bptjm-28	193	23	is	be	AUX
bptjm-28	193	24	approximately	approximately	ADV
bptjm-28	193	25	95	95	NUM
bptjm-28	193	26	nm	nm	NOUN
bptjm-28	193	27	.	.	PUNCT
bptjm-28	194	1	aav	aav	NOUN
bptjm-28	194	2	alongside	alongside	ADP
bptjm-28	194	3	lentiviruses	lentiviruse	NOUN
bptjm-28	194	4	carry	carry	VERB
bptjm-28	194	5	single	single	ADV
bptjm-28	194	6	-	-	PUNCT
bptjm-28	194	7	stranded	strand	VERB
bptjm-28	194	8	dna	dna	NOUN
bptjm-28	194	9	,	,	PUNCT
bptjm-28	194	10	whereas	whereas	SCONJ
bptjm-28	194	11	adenoviral	adenoviral	ADJ
bptjm-28	194	12	vectors	vector	NOUN
bptjm-28	194	13	carry	carry	VERB
bptjm-28	194	14	double	double	ADV
bptjm-28	194	15	-	-	PUNCT
bptjm-28	194	16	stranded	strand	VERB
bptjm-28	194	17	dna40	dna40	NOUN
bptjm-28	194	18	.	.	PUNCT
bptjm-28	195	1	double	double	ADJ
bptjm-28	195	2	-	-	PUNCT
bptjm-28	195	3	stranded	strand	VERB
bptjm-28	195	4	aav	aav	NOUN
bptjm-28	195	5	vectors	vector	NOUN
bptjm-28	195	6	were	be	AUX
bptjm-28	195	7	also	also	ADV
bptjm-28	195	8	formulated	formulate	VERB
bptjm-28	195	9	by	by	ADP
bptjm-28	195	10	mutation	mutation	NOUN
bptjm-28	195	11	of	of	ADP
bptjm-28	195	12	the	the	DET
bptjm-28	195	13	inverted	invert	VERB
bptjm-28	195	14	terminal	terminal	ADJ
bptjm-28	195	15	repeat	repeat	NOUN
bptjm-28	195	16	(	(	PUNCT
bptjm-28	195	17	itr	itr	NOUN
bptjm-28	195	18	)	)	PUNCT
bptjm-28	195	19	.	.	PUNCT
bptjm-28	196	1	these	these	DET
bptjm-28	196	2	vectors	vector	NOUN
bptjm-28	196	3	were	be	AUX
bptjm-28	196	4	shown	show	VERB
bptjm-28	196	5	to	to	PART
bptjm-28	196	6	have	have	VERB
bptjm-28	196	7	better	well	ADJ
bptjm-28	196	8	transduction	transduction	NOUN
bptjm-28	196	9	in	in	ADP
bptjm-28	196	10	many	many	ADJ
bptjm-28	196	11	other	other	ADJ
bptjm-28	196	12	cell	cell	NOUN
bptjm-28	196	13	lines	line	NOUN
bptjm-28	196	14	including	include	VERB
bptjm-28	196	15	in	in	ADP
bptjm-28	196	16	vivo	vivo	ADJ
bptjm-28	196	17	experiments	experiment	NOUN
bptjm-28	196	18	with	with	ADP
bptjm-28	196	19	hepatocytes	hepatocyte	NOUN
bptjm-28	196	20	.	.	PUNCT
bptjm-28	197	1	in	in	ADP
bptjm-28	197	2	comparison	comparison	NOUN
bptjm-28	197	3	to	to	ADP
bptjm-28	197	4	the	the	DET
bptjm-28	197	5	ssaav	ssaav	NOUN
bptjm-28	197	6	,	,	PUNCT
bptjm-28	197	7	the	the	DET
bptjm-28	197	8	dsaav	dsaav	PROPN
bptjm-28	197	9	gene	gene	NOUN
bptjm-28	197	10	helped	help	VERB
bptjm-28	197	11	maintain	maintain	VERB
bptjm-28	197	12	better	well	ADJ
bptjm-28	197	13	transduction	transduction	NOUN
bptjm-28	197	14	and	and	CCONJ
bptjm-28	197	15	better	well	ADJ
bptjm-28	197	16	dna	dna	NOUN
bptjm-28	197	17	stability	stability	NOUN
bptjm-28	197	18	when	when	SCONJ
bptjm-28	197	19	evaluated	evaluate	VERB
bptjm-28	197	20	6	6	NUM
bptjm-28	197	21	months	month	NOUN
bptjm-28	197	22	after	after	ADP
bptjm-28	197	23	the	the	DET
bptjm-28	197	24	initial	initial	NOUN
bptjm-28	197	25	in	in	ADP
bptjm-28	197	26	vivo	vivo	ADJ
bptjm-28	197	27	experiment41	experiment41	NOUN
bptjm-28	197	28	.	.	PUNCT
bptjm-28	198	1	aav	aav	NOUN
bptjm-28	198	2	has	have	VERB
bptjm-28	198	3	a	a	DET
bptjm-28	198	4	lower	low	ADJ
bptjm-28	198	5	packaging	packaging	NOUN
bptjm-28	198	6	capacity	capacity	NOUN
bptjm-28	198	7	consisting	consist	VERB
bptjm-28	198	8	of	of	ADP
bptjm-28	198	9	approximately	approximately	ADV
bptjm-28	198	10	4.7	4.7	NUM
bptjm-28	198	11	kb	kb	NOUN
bptjm-28	198	12	while	while	SCONJ
bptjm-28	198	13	both	both	CCONJ
bptjm-28	198	14	lentiviral	lentiviral	ADJ
bptjm-28	198	15	and	and	CCONJ
bptjm-28	198	16	adenoviral	adenoviral	ADJ
bptjm-28	198	17	vectors	vector	NOUN
bptjm-28	198	18	have	have	VERB
bptjm-28	198	19	approximately	approximately	ADV
bptjm-28	198	20	8	8	NUM
bptjm-28	198	21	kb40	kb40	PROPN
bptjm-28	198	22	.	.	PUNCT
bptjm-28	199	1	this	this	PRON
bptjm-28	199	2	may	may	AUX
bptjm-28	199	3	be	be	AUX
bptjm-28	199	4	a	a	DET
bptjm-28	199	5	limitation	limitation	NOUN
bptjm-28	199	6	due	due	ADP
bptjm-28	199	7	to	to	ADP
bptjm-28	199	8	the	the	DET
bptjm-28	199	9	large	large	ADJ
bptjm-28	199	10	gene	gene	NOUN
bptjm-28	199	11	target	target	NOUN
bptjm-28	199	12	sequence	sequence	NOUN
bptjm-28	199	13	of	of	ADP
bptjm-28	199	14	factors	factor	NOUN
bptjm-28	199	15	8	8	NUM
bptjm-28	199	16	and	and	CCONJ
bptjm-28	199	17	9	9	NUM
bptjm-28	199	18	.	.	X
bptjm-28	200	1	adenoviruses	adenovirus	NOUN
bptjm-28	200	2	and	and	CCONJ
bptjm-28	200	3	aav	aav	NOUN
bptjm-28	200	4	vectors	vector	NOUN
bptjm-28	200	5	are	be	AUX
bptjm-28	200	6	not	not	PART
bptjm-28	200	7	enveloped	envelop	VERB
bptjm-28	200	8	which	which	PRON
bptjm-28	200	9	may	may	AUX
bptjm-28	200	10	cause	cause	VERB
bptjm-28	200	11	more	more	ADJ
bptjm-28	200	12	e	e	NOUN
bptjm-28	200	13	�	�	NOUN
bptjm-28	200	14	cient	cient	NOUN
bptjm-28	200	15	transduction	transduction	NOUN
bptjm-28	200	16	of	of	ADP
bptjm-28	200	17	viral	viral	ADJ
bptjm-28	200	18	dna	dna	NOUN
bptjm-28	200	19	.	.	PUNCT
bptjm-28	201	1	the	the	DET
bptjm-28	201	2	lentiviral	lentiviral	ADJ
bptjm-28	201	3	vector	vector	NOUN
bptjm-28	201	4	is	be	AUX
bptjm-28	201	5	enveloped	envelop	VERB
bptjm-28	201	6	which	which	PRON
bptjm-28	201	7	keeps	keep	VERB
bptjm-28	201	8	it	it	PRON
bptjm-28	201	9	well	well	ADV
bptjm-28	201	10	protected	protect	VERB
bptjm-28	201	11	,	,	PUNCT
bptjm-28	201	12	but	but	CCONJ
bptjm-28	201	13	concurrently	concurrently	ADV
bptjm-28	201	14	if	if	SCONJ
bptjm-28	201	15	the	the	DET
bptjm-28	201	16	envelope	envelope	NOUN
bptjm-28	201	17	is	be	AUX
bptjm-28	201	18	compromised	compromise	VERB
bptjm-28	201	19	,	,	PUNCT
bptjm-28	201	20	the	the	DET
bptjm-28	201	21	virus	virus	NOUN
bptjm-28	201	22	can	can	AUX
bptjm-28	201	23	disintegrate	disintegrate	VERB
bptjm-28	201	24	.	.	PUNCT
bptjm-28	202	1	additionally	additionally	ADV
bptjm-28	202	2	,	,	PUNCT
bptjm-28	202	3	the	the	DET
bptjm-28	202	4	lentivirus	lentivirus	NOUN
bptjm-28	202	5	is	be	AUX
bptjm-28	202	6	double	double	ADV
bptjm-28	202	7	-	-	PUNCT
bptjm-28	202	8	stranded	strand	VERB
bptjm-28	202	9	and	and	CCONJ
bptjm-28	202	10	embeds	embed	VERB
bptjm-28	202	11	itself	itself	PRON
bptjm-28	202	12	well	well	ADV
bptjm-28	202	13	into	into	ADP
bptjm-28	202	14	the	the	DET
bptjm-28	202	15	host	host	NOUN
bptjm-28	202	16	’s	’s	PART
bptjm-28	202	17	dna	dna	NOUN
bptjm-28	202	18	.	.	PUNCT
bptjm-28	203	1	the	the	DET
bptjm-28	203	2	integration	integration	NOUN
bptjm-28	203	3	of	of	ADP
bptjm-28	203	4	the	the	DET
bptjm-28	203	5	viral	viral	ADJ
bptjm-28	203	6	dna	dna	NOUN
bptjm-28	203	7	into	into	ADP
bptjm-28	203	8	the	the	DET
bptjm-28	203	9	host	host	NOUN
bptjm-28	203	10	’s	’s	PART
bptjm-28	203	11	dna	dna	PROPN
bptjm-28	203	12	will	will	AUX
bptjm-28	203	13	prelude	prelude	VERB
bptjm-28	203	14	long	long	ADJ
bptjm-28	203	15	-	-	PUNCT
bptjm-28	203	16	term	term	NOUN
bptjm-28	203	17	transgene	transgene	ADJ
bptjm-28	203	18	expression	expression	NOUN
bptjm-28	203	19	.	.	PUNCT
bptjm-28	204	1	the	the	DET
bptjm-28	204	2	major	major	ADJ
bptjm-28	204	3	disadvantage	disadvantage	NOUN
bptjm-28	204	4	of	of	ADP
bptjm-28	204	5	this	this	DET
bptjm-28	204	6	mechanism	mechanism	NOUN
bptjm-28	204	7	is	be	AUX
bptjm-28	204	8	that	that	SCONJ
bptjm-28	204	9	it	it	PRON
bptjm-28	204	10	can	can	AUX
bptjm-28	204	11	disrupt	disrupt	VERB
bptjm-28	204	12	the	the	DET
bptjm-28	204	13	host	host	NOUN
bptjm-28	204	14	’s	’s	PART
bptjm-28	204	15	genome	genome	NOUN
bptjm-28	204	16	by	by	ADP
bptjm-28	204	17	insertional	insertional	ADJ
bptjm-28	204	18	mutagenesis	mutagenesis	NOUN
bptjm-28	204	19	.	.	PUNCT
bptjm-28	205	1	aav	aav	NOUN
bptjm-28	205	2	and	and	CCONJ
bptjm-28	205	3	adenovirus	adenovirus	NOUN
bptjm-28	205	4	can	can	AUX
bptjm-28	205	5	not	not	PART
bptjm-28	205	6	integrate	integrate	VERB
bptjm-28	205	7	themselves	themselves	PRON
bptjm-28	205	8	into	into	ADP
bptjm-28	205	9	the	the	DET
bptjm-28	205	10	host	host	NOUN
bptjm-28	205	11	cell	cell	NOUN
bptjm-28	205	12	’s	’s	PART
bptjm-28	205	13	dna	dna	NOUN
bptjm-28	205	14	.	.	PUNCT
bptjm-28	206	1	the	the	DET
bptjm-28	206	2	adenoviral	adenoviral	ADJ
bptjm-28	206	3	vector	vector	NOUN
bptjm-28	206	4	is	be	AUX
bptjm-28	206	5	mostly	mostly	ADV
bptjm-28	206	6	used	use	VERB
bptjm-28	206	7	for	for	ADP
bptjm-28	206	8	short	short	ADJ
bptjm-28	206	9	term	term	NOUN
bptjm-28	206	10	uses	use	VERB
bptjm-28	206	11	as	as	SCONJ
bptjm-28	206	12	it	it	PRON
bptjm-28	206	13	is	be	AUX
bptjm-28	206	14	e	e	NOUN
bptjm-28	206	15	�	�	NOUN
bptjm-28	206	16	ective	ective	ADJ
bptjm-28	206	17	in	in	ADP
bptjm-28	206	18	transient	transient	ADJ
bptjm-28	206	19	expression	expression	NOUN
bptjm-28	206	20	unlike	unlike	ADP
bptjm-28	206	21	the	the	DET
bptjm-28	206	22	persistent	persistent	ADJ
bptjm-28	206	23	gene	gene	NOUN
bptjm-28	206	24	expression	expression	NOUN
bptjm-28	206	25	of	of	ADP
bptjm-28	206	26	the	the	DET
bptjm-28	206	27	aav	aav	PROPN
bptjm-28	206	28	and	and	CCONJ
bptjm-28	206	29	berkeley	berkeley	PROPN
bptjm-28	206	30	pharma	pharma	PROPN
bptjm-28	206	31	tech	tech	NOUN
bptjm-28	206	32	journal	journal	NOUN
bptjm-28	206	33	of	of	ADP
bptjm-28	206	34	medicine	medicine	NOUN
bptjm-28	206	35	|	|	ADV
bptjm-28	206	36	133	133	NUM
bptjm-28	206	37	lentiviral	lentiviral	ADJ
bptjm-28	206	38	vectors	vector	NOUN
bptjm-28	206	39	.	.	PUNCT
bptjm-28	207	1	lastly	lastly	ADV
bptjm-28	207	2	,	,	PUNCT
bptjm-28	207	3	immunogenicity	immunogenicity	NOUN
bptjm-28	207	4	decreases	decrease	NOUN
bptjm-28	207	5	of	of	ADP
bptjm-28	207	6	each	each	DET
bptjm-28	207	7	vector	vector	NOUN
bptjm-28	207	8	adenovirus	adenovirus	NOUN
bptjm-28	207	9	,	,	PUNCT
bptjm-28	207	10	aav	aav	NOUN
bptjm-28	207	11	,	,	PUNCT
bptjm-28	207	12	and	and	CCONJ
bptjm-28	207	13	lentivirus	lentivirus	PROPN
bptjm-28	207	14	respectively40	respectively40	NOUN
bptjm-28	207	15	.	.	PUNCT
bptjm-28	208	1	conclusion	conclusion	VERB
bptjm-28	208	2	the	the	DET
bptjm-28	208	3	purpose	purpose	NOUN
bptjm-28	208	4	of	of	ADP
bptjm-28	208	5	this	this	DET
bptjm-28	208	6	review	review	NOUN
bptjm-28	208	7	article	article	NOUN
bptjm-28	208	8	is	be	AUX
bptjm-28	208	9	to	to	PART
bptjm-28	208	10	provide	provide	VERB
bptjm-28	208	11	an	an	DET
bptjm-28	208	12	outlook	outlook	NOUN
bptjm-28	208	13	on	on	ADP
bptjm-28	208	14	the	the	DET
bptjm-28	208	15	current	current	ADJ
bptjm-28	208	16	state	state	NOUN
bptjm-28	208	17	of	of	ADP
bptjm-28	208	18	gene	gene	NOUN
bptjm-28	208	19	therapy	therapy	NOUN
bptjm-28	208	20	as	as	ADP
bptjm-28	208	21	a	a	DET
bptjm-28	208	22	treatment	treatment	NOUN
bptjm-28	208	23	for	for	ADP
bptjm-28	208	24	hemophilia	hemophilia	NOUN
bptjm-28	208	25	.	.	PUNCT
bptjm-28	209	1	results	result	NOUN
bptjm-28	209	2	of	of	ADP
bptjm-28	209	3	recent	recent	ADJ
bptjm-28	209	4	clinical	clinical	ADJ
bptjm-28	209	5	trials	trial	NOUN
bptjm-28	209	6	have	have	AUX
bptjm-28	209	7	proven	prove	VERB
bptjm-28	209	8	to	to	PART
bptjm-28	209	9	be	be	AUX
bptjm-28	209	10	e	e	NOUN
bptjm-28	209	11	�	�	NOUN
bptjm-28	209	12	ective	ective	ADJ
bptjm-28	209	13	in	in	ADP
bptjm-28	209	14	restoring	restore	VERB
bptjm-28	209	15	clotting	clotting	NOUN
bptjm-28	209	16	ability	ability	NOUN
bptjm-28	209	17	in	in	ADP
bptjm-28	209	18	hemophilic	hemophilic	ADJ
bptjm-28	209	19	patients	patient	NOUN
bptjm-28	209	20	.	.	PUNCT
bptjm-28	210	1	by	by	ADP
bptjm-28	210	2	identifying	identify	VERB
bptjm-28	210	3	key	key	ADJ
bptjm-28	210	4	concerns	concern	NOUN
bptjm-28	210	5	with	with	ADP
bptjm-28	210	6	gene	gene	NOUN
bptjm-28	210	7	therapy	therapy	NOUN
bptjm-28	210	8	,	,	PUNCT
bptjm-28	210	9	scientists	scientist	NOUN
bptjm-28	210	10	are	be	AUX
bptjm-28	210	11	taking	take	VERB
bptjm-28	210	12	steps	step	NOUN
bptjm-28	210	13	to	to	PART
bptjm-28	210	14	account	account	VERB
bptjm-28	210	15	for	for	ADP
bptjm-28	210	16	these	these	DET
bptjm-28	210	17	problems	problem	NOUN
bptjm-28	210	18	by	by	ADP
bptjm-28	210	19	utilizing	utilize	VERB
bptjm-28	210	20	the	the	DET
bptjm-28	210	21	following	follow	VERB
bptjm-28	210	22	collection	collection	NOUN
bptjm-28	210	23	of	of	ADP
bptjm-28	210	24	sources	source	NOUN
bptjm-28	210	25	and	and	CCONJ
bptjm-28	210	26	information	information	NOUN
bptjm-28	210	27	to	to	PART
bptjm-28	210	28	make	make	VERB
bptjm-28	210	29	an	an	DET
bptjm-28	210	30	impact	impact	NOUN
bptjm-28	210	31	on	on	ADP
bptjm-28	210	32	their	their	PRON
bptjm-28	210	33	research	research	NOUN
bptjm-28	210	34	the	the	DET
bptjm-28	210	35	�	�	NOUN
bptjm-28	210	36	ndings	nding	NOUN
bptjm-28	210	37	that	that	PRON
bptjm-28	210	38	we	we	PRON
bptjm-28	210	39	make	make	VERB
bptjm-28	210	40	will	will	AUX
bptjm-28	210	41	help	help	VERB
bptjm-28	210	42	other	other	ADJ
bptjm-28	210	43	researchers	researcher	NOUN
bptjm-28	210	44	improve	improve	VERB
bptjm-28	210	45	upon	upon	SCONJ
bptjm-28	210	46	this	this	DET
bptjm-28	210	47	research	research	NOUN
bptjm-28	210	48	to	to	PART
bptjm-28	210	49	have	have	VERB
bptjm-28	210	50	a	a	DET
bptjm-28	210	51	collection	collection	NOUN
bptjm-28	210	52	and	and	CCONJ
bptjm-28	210	53	a	a	DET
bptjm-28	210	54	review	review	NOUN
bptjm-28	210	55	composed	compose	VERB
bptjm-28	210	56	of	of	ADP
bptjm-28	210	57	aav	aav	NOUN
bptjm-28	210	58	vectors	vector	NOUN
bptjm-28	210	59	to	to	PART
bptjm-28	210	60	use	use	VERB
bptjm-28	210	61	in	in	ADP
bptjm-28	210	62	their	their	PRON
bptjm-28	210	63	clinical	clinical	ADJ
bptjm-28	210	64	studies	study	NOUN
bptjm-28	210	65	.	.	PUNCT
bptjm-28	211	1	results	result	NOUN
bptjm-28	211	2	in	in	ADP
bptjm-28	211	3	�	�	NOUN
bptjm-28	211	4	uence	uence	NOUN
bptjm-28	211	5	researchers	researcher	NOUN
bptjm-28	211	6	to	to	PART
bptjm-28	211	7	use	use	VERB
bptjm-28	211	8	the	the	DET
bptjm-28	211	9	aav	aav	NOUN
bptjm-28	211	10	gene	gene	NOUN
bptjm-28	211	11	therapy	therapy	NOUN
bptjm-28	211	12	because	because	SCONJ
bptjm-28	211	13	of	of	ADP
bptjm-28	211	14	its	its	PRON
bptjm-28	211	15	e	e	PROPN
bptjm-28	211	16	�	�	PROPN
bptjm-28	211	17	ectiveness	ectiveness	NOUN
bptjm-28	211	18	in	in	ADP
bptjm-28	211	19	transducing	transducing	NOUN
bptjm-28	211	20	genes	gene	NOUN
bptjm-28	211	21	into	into	ADP
bptjm-28	211	22	hepatocytes	hepatocyte	NOUN
bptjm-28	211	23	.	.	PUNCT
bptjm-28	212	1	just	just	ADV
bptjm-28	212	2	as	as	SCONJ
bptjm-28	212	3	in	in	ADP
bptjm-28	212	4	hemophilia	hemophilia	PROPN
bptjm-28	212	5	,	,	PUNCT
bptjm-28	212	6	aav	aav	NOUN
bptjm-28	212	7	gene	gene	NOUN
bptjm-28	212	8	therapy	therapy	NOUN
bptjm-28	212	9	is	be	AUX
bptjm-28	212	10	a	a	DET
bptjm-28	212	11	useful	useful	ADJ
bptjm-28	212	12	technique	technique	NOUN
bptjm-28	212	13	applicable	applicable	ADJ
bptjm-28	212	14	to	to	ADP
bptjm-28	212	15	many	many	ADJ
bptjm-28	212	16	other	other	ADJ
bptjm-28	212	17	diseases	disease	NOUN
bptjm-28	212	18	,	,	PUNCT
bptjm-28	212	19	which	which	PRON
bptjm-28	212	20	can	can	AUX
bptjm-28	212	21	lead	lead	VERB
bptjm-28	212	22	to	to	ADP
bptjm-28	212	23	more	more	ADJ
bptjm-28	212	24	breakthroughs	breakthrough	NOUN
bptjm-28	212	25	and	and	CCONJ
bptjm-28	212	26	for	for	ADP
bptjm-28	212	27	other	other	ADJ
bptjm-28	212	28	studies	study	NOUN
bptjm-28	212	29	.	.	PUNCT
bptjm-28	213	1	this	this	DET
bptjm-28	213	2	results	result	VERB
bptjm-28	213	3	in	in	ADP
bptjm-28	213	4	longer	long	ADV
bptjm-28	213	5	lasting	last	VERB
bptjm-28	213	6	and	and	CCONJ
bptjm-28	213	7	consistent	consistent	ADJ
bptjm-28	213	8	treatment	treatment	NOUN
bptjm-28	213	9	plans	plan	NOUN
bptjm-28	213	10	after	after	ADP
bptjm-28	213	11	insertion	insertion	NOUN
bptjm-28	213	12	due	due	ADP
bptjm-28	213	13	to	to	ADP
bptjm-28	213	14	the	the	DET
bptjm-28	213	15	limited	limited	ADJ
bptjm-28	213	16	amount	amount	NOUN
bptjm-28	213	17	of	of	ADP
bptjm-28	213	18	insertional	insertional	ADJ
bptjm-28	213	19	mutability17	mutability17	NOUN
bptjm-28	213	20	.	.	PUNCT
bptjm-28	214	1	predicting	predict	VERB
bptjm-28	214	2	or	or	CCONJ
bptjm-28	214	3	compiling	compile	VERB
bptjm-28	214	4	e	e	PROPN
bptjm-28	214	5	�	�	PROPN
bptjm-28	214	6	ective	ective	ADJ
bptjm-28	214	7	aav	aav	NOUN
bptjm-28	214	8	vectors	vector	NOUN
bptjm-28	214	9	and	and	CCONJ
bptjm-28	214	10	their	their	PRON
bptjm-28	214	11	key	key	ADJ
bptjm-28	214	12	qualities	quality	NOUN
bptjm-28	214	13	can	can	AUX
bptjm-28	214	14	advance	advance	VERB
bptjm-28	214	15	further	further	ADJ
bptjm-28	214	16	studies	study	NOUN
bptjm-28	214	17	that	that	PRON
bptjm-28	214	18	want	want	VERB
bptjm-28	214	19	to	to	PART
bptjm-28	214	20	use	use	VERB
bptjm-28	214	21	such	such	ADJ
bptjm-28	214	22	gene	gene	NOUN
bptjm-28	214	23	manipulating	manipulate	VERB
bptjm-28	214	24	technology	technology	NOUN
bptjm-28	214	25	that	that	PRON
bptjm-28	214	26	is	be	AUX
bptjm-28	214	27	not	not	PART
bptjm-28	214	28	as	as	ADV
bptjm-28	214	29	biohazardous	biohazardous	ADJ
bptjm-28	214	30	and	and	CCONJ
bptjm-28	214	31	feasible	feasible	ADJ
bptjm-28	214	32	scheduled	schedule	VERB
bptjm-28	214	33	usage	usage	NOUN
bptjm-28	214	34	as	as	SCONJ
bptjm-28	214	35	it	it	PRON
bptjm-28	214	36	is	be	AUX
bptjm-28	214	37	e	e	NOUN
bptjm-28	214	38	�	�	NOUN
bptjm-28	214	39	ective	ective	NOUN
bptjm-28	214	40	for	for	ADP
bptjm-28	214	41	months17	months17	NOUN
bptjm-28	214	42	.	.	PUNCT
bptjm-28	215	1	with	with	ADP
bptjm-28	215	2	a	a	DET
bptjm-28	215	3	comprehensive	comprehensive	ADJ
bptjm-28	215	4	collection	collection	NOUN
bptjm-28	215	5	of	of	ADP
bptjm-28	215	6	data	datum	NOUN
bptjm-28	215	7	from	from	ADP
bptjm-28	215	8	various	various	ADJ
bptjm-28	215	9	clinical	clinical	ADJ
bptjm-28	215	10	trials	trial	NOUN
bptjm-28	215	11	,	,	PUNCT
bptjm-28	215	12	researchers	researcher	NOUN
bptjm-28	215	13	in	in	ADP
bptjm-28	215	14	the	the	DET
bptjm-28	215	15	future	future	NOUN
bptjm-28	215	16	will	will	AUX
bptjm-28	215	17	also	also	ADV
bptjm-28	215	18	have	have	VERB
bptjm-28	215	19	a	a	DET
bptjm-28	215	20	good	good	ADJ
bptjm-28	215	21	understanding	understanding	NOUN
bptjm-28	215	22	of	of	ADP
bptjm-28	215	23	challenges	challenge	NOUN
bptjm-28	215	24	of	of	ADP
bptjm-28	215	25	such	such	ADJ
bptjm-28	215	26	treatment	treatment	NOUN
bptjm-28	215	27	that	that	PRON
bptjm-28	215	28	requires	require	VERB
bptjm-28	215	29	deliberation	deliberation	NOUN
bptjm-28	215	30	before	before	ADP
bptjm-28	215	31	pursuing	pursue	VERB
bptjm-28	215	32	treatment	treatment	NOUN
bptjm-28	215	33	about	about	ADP
bptjm-28	215	34	options	option	NOUN
bptjm-28	215	35	with	with	ADP
bptjm-28	215	36	the	the	DET
bptjm-28	215	37	type	type	NOUN
bptjm-28	215	38	of	of	ADP
bptjm-28	215	39	aav	aav	NOUN
bptjm-28	215	40	vectors	vector	NOUN
bptjm-28	215	41	to	to	PART
bptjm-28	215	42	use	use	VERB
bptjm-28	215	43	and	and	CCONJ
bptjm-28	215	44	understanding	understand	VERB
bptjm-28	215	45	the	the	DET
bptjm-28	215	46	best	good	ADJ
bptjm-28	215	47	way	way	NOUN
bptjm-28	215	48	to	to	PART
bptjm-28	215	49	infuse	infuse	VERB
bptjm-28	215	50	into	into	ADP
bptjm-28	215	51	the	the	DET
bptjm-28	215	52	body18	body18	NOUN
bptjm-28	215	53	.	.	PUNCT
bptjm-28	216	1	our	our	PRON
bptjm-28	216	2	research	research	NOUN
bptjm-28	216	3	can	can	AUX
bptjm-28	216	4	also	also	ADV
bptjm-28	216	5	advise	advise	VERB
bptjm-28	216	6	a	a	DET
bptjm-28	216	7	potential	potential	ADJ
bptjm-28	216	8	gene	gene	NOUN
bptjm-28	216	9	sequence	sequence	NOUN
bptjm-28	216	10	for	for	ADP
bptjm-28	216	11	further	further	ADJ
bptjm-28	216	12	research	research	NOUN
bptjm-28	216	13	to	to	PART
bptjm-28	216	14	use	use	VERB
bptjm-28	216	15	when	when	SCONJ
bptjm-28	216	16	developing	develop	VERB
bptjm-28	216	17	the	the	DET
bptjm-28	216	18	precise	precise	ADJ
bptjm-28	216	19	gene	gene	NOUN
bptjm-28	216	20	sequence	sequence	NOUN
bptjm-28	216	21	to	to	PART
bptjm-28	216	22	use	use	VERB
bptjm-28	216	23	in	in	ADP
bptjm-28	216	24	future	future	ADJ
bptjm-28	216	25	studies	study	NOUN
bptjm-28	216	26	.	.	PUNCT
bptjm-28	217	1	berkeley	berkeley	PROPN
bptjm-28	217	2	pharma	pharma	PROPN
bptjm-28	217	3	tech	tech	PROPN
bptjm-28	217	4	journal	journal	NOUN
bptjm-28	217	5	of	of	ADP
bptjm-28	217	6	medicine	medicine	NOUN
bptjm-28	217	7	|	|	ADV
bptjm-28	217	8	134	134	NUM
bptjm-28	217	9	references	reference	NOUN
bptjm-28	217	10	1	1	NUM
bptjm-28	217	11	.	.	PUNCT
bptjm-28	218	1	nilsson	nilsson	PROPN
bptjm-28	218	2	i	i	PROPN
bptjm-28	218	3	m	m	PROPN
bptjm-28	218	4	,	,	PUNCT
bptjm-28	218	5	berntorp	berntorp	PROPN
bptjm-28	218	6	e	e	PROPN
bptjm-28	218	7	,	,	PUNCT
bptjm-28	218	8	lofqvist	lofqvist	PROPN
bptjm-28	218	9	t	t	PROPN
bptjm-28	218	10	,	,	PUNCT
bptjm-28	218	11	pettersson	pettersson	PROPN
bptjm-28	218	12	h.	h.	PROPN
bptjm-28	218	13	twenty-	twenty-	X
bptjm-28	218	14	�	�	PROPN
bptjm-28	218	15	ve	ve	NOUN
bptjm-28	218	16	years	year	NOUN
bptjm-28	218	17	'	'	PART
bptjm-28	218	18	experience	experience	NOUN
bptjm-28	218	19	of	of	ADP
bptjm-28	218	20	prophylactic	prophylactic	ADJ
bptjm-28	218	21	treatment	treatment	NOUN
bptjm-28	218	22	in	in	ADP
bptjm-28	218	23	severe	severe	ADJ
bptjm-28	218	24	hemophilia	hemophilia	NOUN
bptjm-28	218	25	.	.	PUNCT
bptjm-28	219	1	a	a	PRON
bptjm-28	219	2	and	and	CCONJ
bptjm-28	219	3	b.	b.	PROPN
bptjm-28	219	4	j	j	PROPN
bptjm-28	219	5	intern	intern	PROPN
bptjm-28	219	6	med	me	VERB
bptjm-28	219	7	.	.	PROPN
bptjm-28	219	8	1992	1992	NUM
bptjm-28	219	9	;	;	PUNCT
bptjm-28	219	10	232	232	NUM
bptjm-28	219	11	:	:	PUNCT
bptjm-28	219	12	25–32	25–32	NUM
bptjm-28	219	13	.	.	NOUN
bptjm-28	220	1	2	2	NUM
bptjm-28	220	2	.	.	X
bptjm-28	220	3	lisowski	lisowski	PROPN
bptjm-28	220	4	,	,	PUNCT
bptjm-28	220	5	l.	l.	PROPN
bptjm-28	220	6	,	,	PUNCT
bptjm-28	220	7	staber	staber	PROPN
bptjm-28	220	8	,	,	PUNCT
bptjm-28	220	9	j.	j.	PROPN
bptjm-28	220	10	m.	m.	PROPN
bptjm-28	220	11	,	,	PUNCT
bptjm-28	220	12	wright	wright	PROPN
bptjm-28	220	13	,	,	PUNCT
bptjm-28	220	14	j.	j.	PROPN
bptjm-28	220	15	f.	f.	PROPN
bptjm-28	220	16	,	,	PUNCT
bptjm-28	220	17	&	&	CCONJ
bptjm-28	220	18	valentino	valentino	PROPN
bptjm-28	220	19	,	,	PUNCT
bptjm-28	221	1	l.	l.	PROPN
bptjm-28	221	2	a.	a.	PROPN
bptjm-28	221	3	(	(	PUNCT
bptjm-28	221	4	2021	2021	NUM
bptjm-28	221	5	)	)	PUNCT
bptjm-28	221	6	.	.	PUNCT
bptjm-28	222	1	the	the	DET
bptjm-28	222	2	intersection	intersection	NOUN
bptjm-28	222	3	of	of	ADP
bptjm-28	222	4	vector	vector	NOUN
bptjm-28	222	5	biology	biology	NOUN
bptjm-28	222	6	,	,	PUNCT
bptjm-28	222	7	gene	gene	NOUN
bptjm-28	222	8	therapy	therapy	NOUN
bptjm-28	222	9	,	,	PUNCT
bptjm-28	222	10	and	and	CCONJ
bptjm-28	222	11	hemophilia	hemophilia	PROPN
bptjm-28	222	12	.	.	PUNCT
bptjm-28	223	1	research	research	NOUN
bptjm-28	223	2	and	and	CCONJ
bptjm-28	223	3	practice	practice	NOUN
bptjm-28	223	4	in	in	ADP
bptjm-28	223	5	thrombosis	thrombosis	NOUN
bptjm-28	223	6	and	and	CCONJ
bptjm-28	223	7	haemostasis	haemostasis	NOUN
bptjm-28	223	8	,	,	PUNCT
bptjm-28	223	9	5(6	5(6	NUM
bptjm-28	223	10	)	)	PUNCT
bptjm-28	223	11	,	,	PUNCT
bptjm-28	223	12	e12586	e12586	PROPN
bptjm-28	223	13	.	.	PROPN
bptjm-28	223	14	https://doi.org/10.1002/rth2.12586	https://doi.org/10.1002/rth2.12586	NOUN
bptjm-28	223	15	3	3	X
bptjm-28	223	16	.	.	X
bptjm-28	224	1	what	what	PRON
bptjm-28	224	2	is	be	AUX
bptjm-28	224	3	hemophilia	hemophilia	PROPN
bptjm-28	224	4	.	.	PUNCT
bptjm-28	225	1	centers	center	NOUN
bptjm-28	225	2	for	for	ADP
bptjm-28	225	3	disease	disease	NOUN
bptjm-28	225	4	control	control	NOUN
bptjm-28	225	5	and	and	CCONJ
bptjm-28	225	6	prevention	prevention	NOUN
bptjm-28	225	7	.	.	PUNCT
bptjm-28	226	1	https://www.cdc.gov/ncbddd/hemophilia/fact	https://www.cdc.gov/ncbddd/hemophilia/fact	PROPN
bptjm-28	226	2	s.html	s.html	PROPN
bptjm-28	226	3	.	.	PUNCT
bptjm-28	227	1	published	publish	VERB
bptjm-28	227	2	july	july	PROPN
bptjm-28	227	3	17	17	NUM
bptjm-28	227	4	,	,	PUNCT
bptjm-28	227	5	2020	2020	NUM
bptjm-28	227	6	.	.	PUNCT
bptjm-28	228	1	accessed	access	VERB
bptjm-28	228	2	march	march	PROPN
bptjm-28	228	3	29	29	NUM
bptjm-28	228	4	,	,	PUNCT
bptjm-28	228	5	2022	2022	NUM
bptjm-28	228	6	.	.	PUNCT
bptjm-28	229	1	4	4	NUM
bptjm-28	229	2	.	.	NOUN
bptjm-28	229	3	fast	fast	ADJ
bptjm-28	229	4	facts	fact	NOUN
bptjm-28	229	5	.	.	PUNCT
bptjm-28	230	1	national	national	PROPN
bptjm-28	230	2	hemophilia	hemophilia	PROPN
bptjm-28	230	3	foundation	foundation	PROPN
bptjm-28	230	4	.	.	PUNCT
bptjm-28	231	1	https://www.hemophilia.org/bleeding-disorde	https://www.hemophilia.org/bleeding-disorde	PROPN
bptjm-28	231	2	rs	rs	PROPN
bptjm-28	231	3	-	-	PUNCT
bptjm-28	231	4	a	a	DET
bptjm-28	231	5	-	-	PUNCT
bptjm-28	231	6	z	z	NOUN
bptjm-28	231	7	/	/	SYM
bptjm-28	231	8	overview	overview	NOUN
bptjm-28	231	9	/	/	SYM
bptjm-28	231	10	fast	fast	ADJ
bptjm-28	231	11	-	-	PUNCT
bptjm-28	231	12	facts	fact	NOUN
bptjm-28	231	13	.	.	PUNCT
bptjm-28	232	1	accessed	access	VERB
bptjm-28	232	2	march	march	PROPN
bptjm-28	232	3	29	29	NUM
bptjm-28	232	4	,	,	PUNCT
bptjm-28	232	5	2022	2022	NUM
bptjm-28	232	6	.	.	PUNCT
bptjm-28	233	1	5	5	NUM
bptjm-28	233	2	.	.	X
bptjm-28	233	3	tbh	tbh	AUX
bptjm-28	233	4	creative	creative	ADJ
bptjm-28	233	5	info@tbhcreative.com	info@tbhcreative.com	X
bptjm-28	233	6	.	.	PUNCT
bptjm-28	233	7	severity	severity	NOUN
bptjm-28	233	8	of	of	ADP
bptjm-28	233	9	hemophilia	hemophilia	PROPN
bptjm-28	233	10	.	.	PUNCT
bptjm-28	234	1	indiana	indiana	PROPN
bptjm-28	234	2	hemophilia	hemophilia	PROPN
bptjm-28	234	3	&	&	CCONJ
bptjm-28	234	4	thrombosis	thrombosis	PROPN
bptjm-28	234	5	center	center	NOUN
bptjm-28	234	6	.	.	PUNCT
bptjm-28	235	1	https://www.ihtc.org/severity-of-hemophilia	https://www.ihtc.org/severity-of-hemophilia	PROPN
bptjm-28	235	2	.	.	PROPN
bptjm-28	236	1	accessed	access	VERB
bptjm-28	236	2	march	march	PROPN
bptjm-28	236	3	29	29	NUM
bptjm-28	236	4	,	,	PUNCT
bptjm-28	236	5	2022	2022	NUM
bptjm-28	236	6	.	.	PUNCT
bptjm-28	237	1	6	6	NUM
bptjm-28	237	2	.	.	X
bptjm-28	237	3	peyvandi	peyvandi	PROPN
bptjm-28	237	4	f	f	PROPN
bptjm-28	237	5	,	,	PUNCT
bptjm-28	237	6	garagiola	garagiola	PROPN
bptjm-28	237	7	i	i	PROPN
bptjm-28	237	8	,	,	PUNCT
bptjm-28	237	9	seregni	seregni	PROPN
bptjm-28	237	10	s.	s.	PROPN
bptjm-28	237	11	future	future	NOUN
bptjm-28	237	12	of	of	ADP
bptjm-28	237	13	coagulation	coagulation	NOUN
bptjm-28	237	14	factor	factor	NOUN
bptjm-28	237	15	replacement	replacement	NOUN
bptjm-28	237	16	therapy	therapy	NOUN
bptjm-28	237	17	.	.	PUNCT
bptjm-28	238	1	j	j	PROPN
bptjm-28	238	2	thromb	thromb	PROPN
bptjm-28	238	3	haemost	haemost	VERB
bptjm-28	238	4	.	.	PUNCT
bptjm-28	239	1	2013;11	2013;11	NUM
bptjm-28	239	2	suppl	suppl	ADJ
bptjm-28	239	3	1:84	1:84	NUM
bptjm-28	239	4	-	-	SYM
bptjm-28	239	5	98	98	NUM
bptjm-28	239	6	.	.	PUNCT
bptjm-28	240	1	doi:10.1111	doi:10.1111	ADJ
bptjm-28	240	2	/	/	SYM
bptjm-28	240	3	jth.12270	jth.12270	NOUN
bptjm-28	240	4	7	7	NUM
bptjm-28	240	5	.	.	PUNCT
bptjm-28	241	1	witmer	witmer	PROPN
bptjm-28	241	2	c	c	PROPN
bptjm-28	241	3	,	,	PUNCT
bptjm-28	241	4	young	young	ADJ
bptjm-28	241	5	g.	g.	NOUN
bptjm-28	241	6	factor	factor	NOUN
bptjm-28	241	7	viii	viii	NOUN
bptjm-28	241	8	inhibitors	inhibitor	NOUN
bptjm-28	241	9	in	in	ADP
bptjm-28	241	10	hemophilia	hemophilia	PROPN
bptjm-28	241	11	a	a	DET
bptjm-28	241	12	:	:	PUNCT
bptjm-28	241	13	rationale	rationale	NOUN
bptjm-28	241	14	and	and	CCONJ
bptjm-28	241	15	latest	late	ADJ
bptjm-28	241	16	evidence	evidence	NOUN
bptjm-28	241	17	.	.	PUNCT
bptjm-28	242	1	ther	ther	VERB
bptjm-28	242	2	adv	adv	PROPN
bptjm-28	242	3	hematol	hematol	NOUN
bptjm-28	242	4	.	.	PUNCT
bptjm-28	243	1	2013;4(1):59	2013;4(1):59	NUM
bptjm-28	243	2	-	-	SYM
bptjm-28	243	3	72	72	NUM
bptjm-28	243	4	.	.	PUNCT
bptjm-28	244	1	doi:10.1177/2040620712464509	doi:10.1177/2040620712464509	ADJ
bptjm-28	244	2	8	8	NUM
bptjm-28	244	3	.	.	PUNCT
bptjm-28	245	1	samelson	samelson	ADJ
bptjm-28	245	2	-	-	PUNCT
bptjm-28	245	3	jones	jones	PROPN
bptjm-28	245	4	bj	bj	PROPN
bptjm-28	245	5	,	,	PUNCT
bptjm-28	245	6	arruda	arruda	PROPN
bptjm-28	245	7	vr	vr	PROPN
bptjm-28	245	8	.	.	PROPN
bptjm-28	245	9	protein	protein	NOUN
bptjm-28	245	10	-	-	PUNCT
bptjm-28	245	11	engineered	engineer	VERB
bptjm-28	245	12	coagulation	coagulation	NOUN
bptjm-28	245	13	factors	factor	NOUN
bptjm-28	245	14	for	for	ADP
bptjm-28	245	15	hemophilia	hemophilia	NOUN
bptjm-28	245	16	gene	gene	NOUN
bptjm-28	245	17	therapy	therapy	NOUN
bptjm-28	245	18	.	.	PUNCT
bptjm-28	246	1	mol	mol	ADP
bptjm-28	246	2	ther	ther	PROPN
bptjm-28	246	3	methods	method	NOUN
bptjm-28	246	4	clin	clin	PROPN
bptjm-28	246	5	dev	dev	PROPN
bptjm-28	246	6	.	.	PUNCT
bptjm-28	247	1	2018;12:184	2018;12:184	NUM
bptjm-28	247	2	-	-	SYM
bptjm-28	247	3	201	201	NUM
bptjm-28	247	4	.	.	PUNCT
bptjm-28	248	1	published	publish	VERB
bptjm-28	248	2	2018	2018	NUM
bptjm-28	248	3	dec	dec	PROPN
bptjm-28	248	4	31	31	NUM
bptjm-28	248	5	.	.	PUNCT
bptjm-28	249	1	doi:10.1016	doi:10.1016	PROPN
bptjm-28	249	2	/	/	SYM
bptjm-28	249	3	j.omtm.2018.12.007	j.omtm.2018.12.007	PROPN
bptjm-28	249	4	9	9	NUM
bptjm-28	249	5	.	.	PUNCT
bptjm-28	250	1	alam	alam	PROPN
bptjm-28	250	2	a	a	PROPN
bptjm-28	250	3	,	,	PUNCT
bptjm-28	250	4	doshi	doshi	PROPN
bptjm-28	250	5	h	h	PROPN
bptjm-28	250	6	,	,	PUNCT
bptjm-28	250	7	patel	patel	PROPN
bptjm-28	250	8	dn	dn	PROPN
bptjm-28	250	9	,	,	PUNCT
bptjm-28	250	10	patel	patel	PROPN
bptjm-28	250	11	k	k	PROPN
bptjm-28	250	12	,	,	PUNCT
bptjm-28	250	13	james	james	PROPN
bptjm-28	250	14	d	d	PROPN
bptjm-28	250	15	,	,	PUNCT
bptjm-28	250	16	almendral	almendral	ADJ
bptjm-28	250	17	j.	j.	PROPN
bptjm-28	250	18	myocardial	myocardial	ADJ
bptjm-28	250	19	infarction	infarction	NOUN
bptjm-28	250	20	and	and	CCONJ
bptjm-28	250	21	factor	factor	NOUN
bptjm-28	250	22	viii	viii	NOUN
bptjm-28	250	23	elevation	elevation	NOUN
bptjm-28	250	24	in	in	ADP
bptjm-28	250	25	a	a	DET
bptjm-28	250	26	36	36	NUM
bptjm-28	250	27	-	-	PUNCT
bptjm-28	250	28	year	year	NOUN
bptjm-28	250	29	-	-	PUNCT
bptjm-28	250	30	old	old	ADJ
bptjm-28	250	31	man	man	NOUN
bptjm-28	250	32	.	.	PUNCT
bptjm-28	251	1	proc	proc	NOUN
bptjm-28	251	2	(	(	PUNCT
bptjm-28	251	3	bayl	bayl	PROPN
bptjm-28	251	4	univ	univ	PROPN
bptjm-28	251	5	med	med	PROPN
bptjm-28	251	6	cent	cent	NOUN
bptjm-28	251	7	)	)	PUNCT
bptjm-28	251	8	.	.	PUNCT
bptjm-28	252	1	2021;35(1):93	2021;35(1):93	NUM
bptjm-28	252	2	-	-	SYM
bptjm-28	252	3	95	95	NUM
bptjm-28	252	4	.	.	PUNCT
bptjm-28	253	1	published	publish	VERB
bptjm-28	253	2	2021	2021	NUM
bptjm-28	253	3	sep	sep	NOUN
bptjm-28	253	4	15	15	NUM
bptjm-28	253	5	.	.	PUNCT
bptjm-28	254	1	doi:10.1080/08998280.2021.1973285	doi:10.1080/08998280.2021.1973285	PROPN
bptjm-28	254	2	10	10	NUM
bptjm-28	254	3	.	.	PUNCT
bptjm-28	255	1	castaman	castaman	PROPN
bptjm-28	255	2	g.	g.	PROPN
bptjm-28	255	3	treatment	treatment	PROPN
bptjm-28	255	4	of	of	ADP
bptjm-28	255	5	von	von	PROPN
bptjm-28	255	6	willebrand	willebrand	PROPN
bptjm-28	255	7	disease	disease	NOUN
bptjm-28	255	8	with	with	ADP
bptjm-28	255	9	fviii	fviii	NOUN
bptjm-28	255	10	/	/	SYM
bptjm-28	255	11	vwf	vwf	NOUN
bptjm-28	255	12	concentrates	concentrate	VERB
bptjm-28	255	13	.	.	PUNCT
bptjm-28	256	1	blood	blood	NOUN
bptjm-28	256	2	transfus	transfus	PROPN
bptjm-28	256	3	.	.	PUNCT
bptjm-28	257	1	2011;9	2011;9	NUM
bptjm-28	257	2	suppl	suppl	PROPN
bptjm-28	257	3	2(suppl	2(suppl	PROPN
bptjm-28	257	4	2):s9	2):s9	NUM
bptjm-28	257	5	-	-	PUNCT
bptjm-28	257	6	s13	s13	NOUN
bptjm-28	257	7	.	.	PUNCT
bptjm-28	258	1	doi:10.2450/2011.003s	doi:10.2450/2011.003s	PROPN
bptjm-28	258	2	11	11	NUM
bptjm-28	258	3	.	.	PUNCT
bptjm-28	259	1	nogami	nogami	PROPN
bptjm-28	259	2	k	k	PROPN
bptjm-28	259	3	,	,	PUNCT
bptjm-28	259	4	zhou	zhou	PROPN
bptjm-28	259	5	q	q	PROPN
bptjm-28	259	6	,	,	PUNCT
bptjm-28	259	7	wakabayashi	wakabayashi	PROPN
bptjm-28	259	8	h	h	NOUN
bptjm-28	259	9	,	,	PUNCT
bptjm-28	259	10	fay	fay	PROPN
bptjm-28	259	11	pj	pj	PROPN
bptjm-28	259	12	.	.	PUNCT
bptjm-28	260	1	thrombin	thrombin	NOUN
bptjm-28	260	2	-	-	PUNCT
bptjm-28	260	3	catalyzed	catalyze	VERB
bptjm-28	260	4	activation	activation	NOUN
bptjm-28	260	5	of	of	ADP
bptjm-28	260	6	factor	factor	NOUN
bptjm-28	260	7	viii	viii	NOUN
bptjm-28	260	8	with	with	ADP
bptjm-28	260	9	his	his	PRON
bptjm-28	260	10	substituted	substitute	VERB
bptjm-28	260	11	for	for	ADP
bptjm-28	260	12	arg372	arg372	PROPN
bptjm-28	260	13	at	at	ADP
bptjm-28	260	14	the	the	DET
bptjm-28	260	15	p1	p1	PROPN
bptjm-28	260	16	site	site	NOUN
bptjm-28	260	17	.	.	PUNCT
bptjm-28	261	1	blood	blood	NOUN
bptjm-28	261	2	.	.	PUNCT
bptjm-28	262	1	2005;105(11):4362	2005;105(11):4362	NUM
bptjm-28	262	2	-	-	SYM
bptjm-28	262	3	4368	4368	NUM
bptjm-28	262	4	.	.	PUNCT
bptjm-28	263	1	doi:10.1182	doi:10.1182	NOUN
bptjm-28	263	2	/	/	SYM
bptjm-28	263	3	blood-2004	blood-2004	NOUN
bptjm-28	263	4	-	-	PUNCT
bptjm-28	263	5	10	10	NUM
bptjm-28	263	6	-	-	PUNCT
bptjm-28	263	7	3939	3939	NUM
bptjm-28	263	8	12	12	NUM
bptjm-28	263	9	.	.	PUNCT
bptjm-28	264	1	rachel	rachel	PROPN
bptjm-28	264	2	m.	m.	PROPN
bptjm-28	264	3	lieser	lieser	PROPN
bptjm-28	264	4	,	,	PUNCT
bptjm-28	264	5	daniel	daniel	PROPN
bptjm-28	264	6	yur	yur	PROPN
bptjm-28	264	7	,	,	PUNCT
bptjm-28	264	8	millicent	millicent	PROPN
bptjm-28	264	9	o.	o.	PROPN
bptjm-28	264	10	sullivan	sullivan	PROPN
bptjm-28	264	11	,	,	PUNCT
bptjm-28	264	12	and	and	CCONJ
bptjm-28	264	13	wilfred	wilfred	PROPN
bptjm-28	264	14	chen	chen	PROPN
bptjm-28	264	15	.	.	PUNCT
bptjm-28	265	1	bioconjugate	bioconjugate	PROPN
bptjm-28	265	2	chemistry	chemistry	NOUN
bptjm-28	265	3	.	.	PUNCT
bptjm-28	266	1	2020	2020	NUM
bptjm-28	266	2	31	31	NUM
bptjm-28	266	3	(	(	PUNCT
bptjm-28	266	4	10	10	NUM
bptjm-28	266	5	)	)	PUNCT
bptjm-28	266	6	,	,	PUNCT
bptjm-28	266	7	2272	2272	NUM
bptjm-28	266	8	-	-	SYM
bptjm-28	266	9	2282	2282	NUM
bptjm-28	266	10	.	.	PUNCT
bptjm-28	267	1	doi	doi	NOUN
bptjm-28	267	2	:	:	PUNCT
bptjm-28	267	3	10.1021	10.1021	NUM
bptjm-28	267	4	/	/	SYM
bptjm-28	267	5	acs.bioconjchem.0c00456	acs.bioconjchem.0c00456	NOUN
bptjm-28	267	6	13	13	NUM
bptjm-28	267	7	.	.	PUNCT
bptjm-28	268	1	sadiki	sadiki	PROPN
bptjm-28	268	2	a	a	PROPN
bptjm-28	268	3	,	,	PUNCT
bptjm-28	268	4	vaidya	vaidya	PROPN
bptjm-28	268	5	sr	sr	PROPN
bptjm-28	268	6	,	,	PUNCT
bptjm-28	268	7	abdollahi	abdollahi	PROPN
bptjm-28	268	8	m	m	PROPN
bptjm-28	268	9	,	,	PUNCT
bptjm-28	268	10	et	et	PROPN
bptjm-28	268	11	al	al	PROPN
bptjm-28	268	12	.	.	PROPN
bptjm-28	268	13	site	site	PROPN
bptjm-28	268	14	-	-	PUNCT
bptjm-28	268	15	speci	speci	X
bptjm-28	268	16	�	�	PROPN
bptjm-28	268	17	c	c	NOUN
bptjm-28	268	18	conjugation	conjugation	NOUN
bptjm-28	268	19	of	of	ADP
bptjm-28	268	20	native	native	ADJ
bptjm-28	268	21	antibody	antibody	NOUN
bptjm-28	268	22	.	.	PUNCT
bptjm-28	269	1	antib	antib	ADJ
bptjm-28	269	2	ther	ther	PROPN
bptjm-28	269	3	.	.	PUNCT
bptjm-28	270	1	2020;3(4):271	2020;3(4):271	NUM
bptjm-28	270	2	-	-	SYM
bptjm-28	270	3	284	284	NUM
bptjm-28	270	4	.	.	PUNCT
bptjm-28	271	1	doi:10.1093	doi:10.1093	NOUN
bptjm-28	271	2	/	/	SYM
bptjm-28	271	3	abt	abt	PROPN
bptjm-28	271	4	/	/	SYM
bptjm-28	271	5	tbaa027	tbaa027	PROPN
bptjm-28	271	6	14	14	NUM
bptjm-28	271	7	.	.	PUNCT
bptjm-28	272	1	protect	protect	VERB
bptjm-28	272	2	viii	viii	ADJ
bptjm-28	272	3	study	study	NOUN
bptjm-28	272	4	design	design	NOUN
bptjm-28	272	5	.	.	PUNCT
bptjm-28	273	1	jivi	jivi	VERB
bptjm-28	273	2	us	us	PROPN
bptjm-28	273	3	hcp	hcp	PROPN
bptjm-28	273	4	.	.	PUNCT
bptjm-28	274	1	https://www.jivihcp.com/en/protect-viii-trial	https://www.jivihcp.com/en/protect-viii-trial	PROPN
bptjm-28	274	2	.	.	PUNCT
bptjm-28	275	1	accessed	access	VERB
bptjm-28	275	2	march	march	PROPN
bptjm-28	275	3	29	29	NUM
bptjm-28	275	4	,	,	PUNCT
bptjm-28	275	5	2022	2022	NUM
bptjm-28	275	6	.	.	PUNCT
bptjm-28	276	1	15	15	NUM
bptjm-28	276	2	.	.	X
bptjm-28	277	1	samelson	samelson	ADJ
bptjm-28	277	2	-	-	PUNCT
bptjm-28	277	3	jones	jones	PROPN
bptjm-28	277	4	bj	bj	PROPN
bptjm-28	277	5	,	,	PUNCT
bptjm-28	277	6	arruda	arruda	PROPN
bptjm-28	277	7	vr	vr	PROPN
bptjm-28	277	8	.	.	PROPN
bptjm-28	277	9	protein	protein	NOUN
bptjm-28	277	10	-	-	PUNCT
bptjm-28	277	11	engineered	engineer	VERB
bptjm-28	277	12	coagulation	coagulation	NOUN
bptjm-28	277	13	factors	factor	NOUN
bptjm-28	277	14	for	for	ADP
bptjm-28	277	15	hemophilia	hemophilia	NOUN
bptjm-28	277	16	gene	gene	NOUN
bptjm-28	277	17	therapy	therapy	NOUN
bptjm-28	277	18	.	.	PUNCT
bptjm-28	278	1	mol	mol	ADP
bptjm-28	278	2	ther	ther	PROPN
bptjm-28	278	3	methods	method	NOUN
bptjm-28	278	4	clin	clin	PROPN
bptjm-28	278	5	dev	dev	PROPN
bptjm-28	278	6	.	.	PUNCT
bptjm-28	279	1	2018;12:184	2018;12:184	NUM
bptjm-28	279	2	-	-	SYM
bptjm-28	279	3	201	201	NUM
bptjm-28	279	4	.	.	PUNCT
bptjm-28	280	1	published	publish	VERB
bptjm-28	280	2	2018	2018	NUM
bptjm-28	280	3	dec	dec	PROPN
bptjm-28	280	4	31	31	NUM
bptjm-28	280	5	.	.	PUNCT
bptjm-28	281	1	doi:10.1016	doi:10.1016	PROPN
bptjm-28	281	2	/	/	SYM
bptjm-28	281	3	j.omtm.2018.12.007	j.omtm.2018.12.007	PROPN
bptjm-28	281	4	16	16	NUM
bptjm-28	281	5	.	.	PUNCT
bptjm-28	282	1	curiel	curiel	PROPN
bptjm-28	282	2	dt	dt	PROPN
bptjm-28	282	3	,	,	PUNCT
bptjm-28	282	4	fisher	fisher	PROPN
bptjm-28	282	5	pb	pb	PROPN
bptjm-28	282	6	,	,	PUNCT
bptjm-28	282	7	tew	tew	PROPN
bptjm-28	282	8	kd	kd	PROPN
bptjm-28	282	9	,	,	PUNCT
bptjm-28	282	10	kaliberov	kaliberov	PROPN
bptjm-28	282	11	sa	sa	PROPN
bptjm-28	282	12	.	.	PUNCT
bptjm-28	282	13	chapter	chapter	NOUN
bptjm-28	282	14	seven	seven	NUM
bptjm-28	282	15	cancer	cancer	NOUN
bptjm-28	282	16	treatment	treatment	NOUN
bptjm-28	282	17	with	with	ADP
bptjm-28	282	18	berkeley	berkeley	PROPN
bptjm-28	282	19	pharma	pharma	PROPN
bptjm-28	282	20	tech	tech	NOUN
bptjm-28	282	21	journal	journal	NOUN
bptjm-28	282	22	of	of	ADP
bptjm-28	282	23	medicine	medicine	NOUN
bptjm-28	282	24	|	|	ADV
bptjm-28	282	25	135	135	NUM
bptjm-28	282	26	gene	gene	NOUN
bptjm-28	282	27	therapy	therapy	NOUN
bptjm-28	282	28	and	and	CCONJ
bptjm-28	282	29	radiation	radiation	NOUN
bptjm-28	282	30	therapy	therapy	NOUN
bptjm-28	282	31	.	.	PUNCT
bptjm-28	283	1	in	in	ADP
bptjm-28	283	2	:	:	PUNCT
bptjm-28	283	3	advances	advance	NOUN
bptjm-28	283	4	in	in	ADP
bptjm-28	283	5	cancer	cancer	NOUN
bptjm-28	283	6	research	research	NOUN
bptjm-28	283	7	.	.	PUNCT
bptjm-28	284	1	amsterdam	amsterdam	PROPN
bptjm-28	284	2	:	:	PUNCT
bptjm-28	284	3	elsevier	elsevier	PROPN
bptjm-28	284	4	academic	academic	NOUN
bptjm-28	284	5	;	;	PUNCT
bptjm-28	284	6	2012:221	2012:221	NUM
bptjm-28	284	7	-	-	PUNCT
bptjm-28	284	8	263	263	NUM
bptjm-28	284	9	.	.	PUNCT
bptjm-28	285	1	17	17	NUM
bptjm-28	285	2	.	.	X
bptjm-28	285	3	aschauer	aschauer	PROPN
bptjm-28	285	4	df	df	PROPN
bptjm-28	285	5	,	,	PUNCT
bptjm-28	285	6	kreuz	kreuz	PROPN
bptjm-28	285	7	s	s	PROPN
bptjm-28	285	8	,	,	PUNCT
bptjm-28	285	9	rumpel	rumpel	PROPN
bptjm-28	285	10	s	s	PROPN
bptjm-28	285	11	(	(	PUNCT
bptjm-28	285	12	2013	2013	NUM
bptjm-28	285	13	)	)	PUNCT
bptjm-28	285	14	analysis	analysis	NOUN
bptjm-28	285	15	of	of	ADP
bptjm-28	285	16	transduction	transduction	NOUN
bptjm-28	285	17	e	e	NOUN
bptjm-28	285	18	�	�	NOUN
bptjm-28	285	19	ciency	ciency	NOUN
bptjm-28	285	20	,	,	PUNCT
bptjm-28	285	21	tropism	tropism	NOUN
bptjm-28	285	22	and	and	CCONJ
bptjm-28	285	23	axonal	axonal	ADJ
bptjm-28	285	24	transport	transport	NOUN
bptjm-28	285	25	of	of	ADP
bptjm-28	285	26	aav	aav	PROPN
bptjm-28	285	27	serotypes	serotype	NOUN
bptjm-28	285	28	1	1	NUM
bptjm-28	285	29	,	,	PUNCT
bptjm-28	285	30	2	2	NUM
bptjm-28	285	31	,	,	PUNCT
bptjm-28	285	32	5	5	NUM
bptjm-28	285	33	,	,	PUNCT
bptjm-28	285	34	6	6	NUM
bptjm-28	285	35	,	,	PUNCT
bptjm-28	285	36	8	8	NUM
bptjm-28	285	37	and	and	CCONJ
bptjm-28	285	38	9	9	NUM
bptjm-28	285	39	in	in	ADP
bptjm-28	285	40	the	the	DET
bptjm-28	285	41	mouse	mouse	NOUN
bptjm-28	285	42	brain	brain	NOUN
bptjm-28	285	43	.	.	PUNCT
bptjm-28	286	1	plos	plos	PROPN
bptjm-28	286	2	one	one	NUM
bptjm-28	286	3	8(9	8(9	NOUN
bptjm-28	286	4	):	):	PUNCT
bptjm-28	286	5	e76310	e76310	PROPN
bptjm-28	286	6	.	.	PUNCT
bptjm-28	287	1	https://doi.org/10.1371/journal.pone.007630	https://doi.org/10.1371/journal.pone.007630	PROPN
bptjm-28	287	2	18	18	NUM
bptjm-28	287	3	.	.	PUNCT
bptjm-28	288	1	el	el	PROPN
bptjm-28	288	2	andari	andari	PROPN
bptjm-28	288	3	,	,	PUNCT
bptjm-28	288	4	j.	j.	PROPN
bptjm-28	288	5	and	and	CCONJ
bptjm-28	288	6	grimm	grimm	PROPN
bptjm-28	288	7	,	,	PUNCT
bptjm-28	288	8	d.	d.	PROPN
bptjm-28	288	9	(	(	PUNCT
bptjm-28	288	10	2021	2021	NUM
bptjm-28	288	11	)	)	PUNCT
bptjm-28	288	12	,	,	PUNCT
bptjm-28	288	13	production	production	NOUN
bptjm-28	288	14	,	,	PUNCT
bptjm-28	288	15	processing	processing	NOUN
bptjm-28	288	16	,	,	PUNCT
bptjm-28	288	17	and	and	CCONJ
bptjm-28	288	18	characterization	characterization	NOUN
bptjm-28	288	19	of	of	ADP
bptjm-28	288	20	synthetic	synthetic	ADJ
bptjm-28	288	21	aav	aav	NOUN
bptjm-28	288	22	gene	gene	NOUN
bptjm-28	288	23	therapy	therapy	NOUN
bptjm-28	288	24	vectors	vector	NOUN
bptjm-28	288	25	.	.	PUNCT
bptjm-28	289	1	biotechnol	biotechnol	PROPN
bptjm-28	289	2	.	.	PUNCT
bptjm-28	290	1	j.	j.	PROPN
bptjm-28	290	2	,	,	PUNCT
bptjm-28	290	3	16	16	NUM
bptjm-28	290	4	:	:	SYM
bptjm-28	290	5	2000025	2000025	NUM
bptjm-28	290	6	.	.	PUNCT
bptjm-28	291	1	https://doi.org/10.1002/biot.202000025	https://doi.org/10.1002/biot.202000025	ADV
bptjm-28	291	2	19	19	NUM
bptjm-28	291	3	.	.	PUNCT
bptjm-28	292	1	factor	factor	NOUN
bptjm-28	292	2	viii	viii	NOUN
bptjm-28	292	3	(	(	PUNCT
bptjm-28	292	4	fviii	fviii	NOUN
bptjm-28	292	5	)	)	PUNCT
bptjm-28	292	6	.	.	PUNCT
bptjm-28	293	1	diapharma	diapharma	NOUN
bptjm-28	293	2	.	.	PUNCT
bptjm-28	294	1	https://diapharma.com/factor-viii/.	https://diapharma.com/factor-viii/.	NOUN
bptjm-28	294	2	published	publish	VERB
bptjm-28	294	3	november	november	PROPN
bptjm-28	294	4	15	15	NUM
bptjm-28	294	5	,	,	PUNCT
bptjm-28	294	6	2021	2021	NUM
bptjm-28	294	7	.	.	PUNCT
bptjm-28	295	1	accessed	access	VERB
bptjm-28	295	2	march	march	PROPN
bptjm-28	295	3	29	29	NUM
bptjm-28	295	4	,	,	PUNCT
bptjm-28	295	5	2022	2022	NUM
bptjm-28	295	6	.	.	PUNCT
bptjm-28	296	1	20	20	NUM
bptjm-28	296	2	.	.	PUNCT
bptjm-28	296	3	fviii	fviii	NOUN
bptjm-28	296	4	:	:	PUNCT
bptjm-28	296	5	a	a	DET
bptjm-28	296	6	crucial	crucial	ADJ
bptjm-28	296	7	hemostatic	hemostatic	ADJ
bptjm-28	296	8	factor	factor	NOUN
bptjm-28	296	9	to	to	PART
bptjm-28	296	10	control	control	VERB
bptjm-28	296	11	bleeding	bleeding	NOUN
bptjm-28	296	12	.	.	PUNCT
bptjm-28	297	1	educ8	educ8	PROPN
bptjm-28	297	2	.	.	PUNCT
bptjm-28	298	1	https://www.educ8-h2020.eu/esrs-blog/fviii-acrucial-hemostatic-factor-to-control-bleeding	https://www.educ8-h2020.eu/esrs-blog/fviii-acrucial-hemostatic-factor-to-control-bleede	VERB
bptjm-28	298	2	.	.	PROPN
bptjm-28	299	1	accessed	access	VERB
bptjm-28	299	2	march	march	PROPN
bptjm-28	299	3	29	29	NUM
bptjm-28	299	4	,	,	PUNCT
bptjm-28	299	5	2022	2022	NUM
bptjm-28	299	6	.	.	PUNCT
bptjm-28	300	1	21	21	NUM
bptjm-28	300	2	.	.	PUNCT
bptjm-28	301	1	nienhuis	nienhuis	PROPN
bptjm-28	301	2	aw	aw	INTJ
bptjm-28	301	3	,	,	PUNCT
bptjm-28	301	4	nathwani	nathwani	PROPN
bptjm-28	301	5	ac	ac	PROPN
bptjm-28	301	6	,	,	PUNCT
bptjm-28	301	7	davido	davido	ADJ
bptjm-28	301	8	�	�	PROPN
bptjm-28	301	9	am	be	AUX
bptjm-28	301	10	.	.	PUNCT
bptjm-28	302	1	gene	gene	NOUN
bptjm-28	302	2	therapy	therapy	NOUN
bptjm-28	302	3	for	for	ADP
bptjm-28	302	4	hemophilia	hemophilia	PROPN
bptjm-28	302	5	.	.	PUNCT
bptjm-28	303	1	in	in	ADP
bptjm-28	303	2	:	:	PUNCT
bptjm-28	303	3	molecular	molecular	ADJ
bptjm-28	303	4	therapy	therapy	NOUN
bptjm-28	303	5	.	.	PUNCT
bptjm-28	304	1	vol	vol	NOUN
bptjm-28	304	2	25	25	NUM
bptjm-28	304	3	.	.	PUNCT
bptjm-28	305	1	5th	5th	ADJ
bptjm-28	305	2	ed	ed	NOUN
bptjm-28	305	3	.	.	PUNCT
bptjm-28	305	4	cellpress	cellpress	NOUN
bptjm-28	305	5	;	;	PUNCT
bptjm-28	305	6	2017:1163	2017:1163	NUM
bptjm-28	305	7	-	-	SYM
bptjm-28	305	8	1167	1167	NUM
bptjm-28	305	9	.	.	PUNCT
bptjm-28	306	1	22	22	NUM
bptjm-28	306	2	.	.	PUNCT
bptjm-28	307	1	sands	sand	NOUN
bptjm-28	307	2	m.s	m.s	PROPN
bptjm-28	307	3	.	.	PUNCT
bptjm-28	308	1	(	(	PUNCT
bptjm-28	308	2	2012	2012	NUM
bptjm-28	308	3	)	)	PUNCT
bptjm-28	308	4	aav	aav	NOUN
bptjm-28	308	5	-	-	PUNCT
bptjm-28	308	6	mediated	mediate	VERB
bptjm-28	308	7	liver	liver	NOUN
bptjm-28	308	8	-	-	PUNCT
bptjm-28	308	9	directed	direct	VERB
bptjm-28	308	10	gene	gene	NOUN
bptjm-28	308	11	therapy	therapy	NOUN
bptjm-28	308	12	.	.	PUNCT
bptjm-28	309	1	in	in	ADP
bptjm-28	309	2	:	:	PUNCT
bptjm-28	309	3	snyder	snyder	PROPN
bptjm-28	309	4	r.	r.	PROPN
bptjm-28	309	5	,	,	PUNCT
bptjm-28	309	6	moullier	moullier	ADV
bptjm-28	309	7	p.	p.	NOUN
bptjm-28	309	8	(	(	PUNCT
bptjm-28	309	9	eds	ed	NOUN
bptjm-28	309	10	)	)	PUNCT
bptjm-28	309	11	adeno	adeno	NOUN
bptjm-28	309	12	-	-	PUNCT
bptjm-28	309	13	associated	associate	VERB
bptjm-28	309	14	virus	virus	NOUN
bptjm-28	309	15	.	.	PUNCT
bptjm-28	310	1	methods	method	NOUN
bptjm-28	310	2	in	in	ADP
bptjm-28	310	3	molecular	molecular	ADJ
bptjm-28	310	4	biology	biology	NOUN
bptjm-28	310	5	(	(	PUNCT
bptjm-28	310	6	methods	method	NOUN
bptjm-28	310	7	and	and	CCONJ
bptjm-28	310	8	protocols	protocol	NOUN
bptjm-28	310	9	)	)	PUNCT
bptjm-28	310	10	,	,	PUNCT
bptjm-28	310	11	vol	vol	NOUN
bptjm-28	310	12	807	807	NUM
bptjm-28	310	13	.	.	PUNCT
bptjm-28	311	1	humana	humana	PROPN
bptjm-28	311	2	press	press	PROPN
bptjm-28	311	3	.	.	PUNCT
bptjm-28	312	1	https://doi.org/10.1007/978-1-61779-370-7_6	https://doi.org/10.1007/978-1-61779-370-7_6	PROPN
bptjm-28	312	2	23	23	NUM
bptjm-28	312	3	.	.	PUNCT
bptjm-28	313	1	fisher	fisher	PROPN
bptjm-28	313	2	kj	kj	PROPN
bptjm-28	313	3	,	,	PUNCT
bptjm-28	313	4	gao	gao	PROPN
bptjm-28	313	5	gp	gp	PROPN
bptjm-28	313	6	,	,	PUNCT
bptjm-28	313	7	weitzman	weitzman	PROPN
bptjm-28	313	8	md	md	PROPN
bptjm-28	313	9	,	,	PUNCT
bptjm-28	313	10	dematteo	dematteo	NOUN
bptjm-28	313	11	r	r	NOUN
bptjm-28	313	12	,	,	PUNCT
bptjm-28	313	13	burda	burda	PROPN
bptjm-28	313	14	jf	jf	PROPN
bptjm-28	313	15	,	,	PUNCT
bptjm-28	313	16	wilson	wilson	PROPN
bptjm-28	313	17	jm	jm	PROPN
bptjm-28	313	18	.	.	PROPN
bptjm-28	313	19	transduction	transduction	NOUN
bptjm-28	313	20	with	with	ADP
bptjm-28	313	21	recombinant	recombinant	ADJ
bptjm-28	313	22	adeno	adeno	NOUN
bptjm-28	313	23	-	-	PUNCT
bptjm-28	313	24	associated	associate	VERB
bptjm-28	313	25	virus	virus	NOUN
bptjm-28	313	26	for	for	ADP
bptjm-28	313	27	gene	gene	NOUN
bptjm-28	313	28	therapy	therapy	NOUN
bptjm-28	313	29	is	be	AUX
bptjm-28	313	30	limited	limit	VERB
bptjm-28	313	31	by	by	ADP
bptjm-28	313	32	leading	lead	VERB
bptjm-28	313	33	-	-	PUNCT
bptjm-28	313	34	strand	strand	NOUN
bptjm-28	313	35	synthesis	synthesis	NOUN
bptjm-28	313	36	.	.	PUNCT
bptjm-28	314	1	j	j	PROPN
bptjm-28	314	2	virology	virology	NOUN
bptjm-28	314	3	.	.	PUNCT
bptjm-28	315	1	1996;70(1):520	1996;70(1):520	NUM
bptjm-28	315	2	-	-	SYM
bptjm-28	315	3	532	532	NUM
bptjm-28	315	4	.	.	PUNCT
bptjm-28	315	5	doi:10.1128	doi:10.1128	NOUN
bptjm-28	315	6	/	/	SYM
bptjm-28	315	7	jvi.70.1.520	jvi.70.1.520	PROPN
bptjm-28	315	8	-	-	PROPN
bptjm-28	315	9	532.1996	532.1996	NUM
bptjm-28	315	10	24	24	NUM
bptjm-28	315	11	.	.	PUNCT
bptjm-28	315	12	nathwani	nathwani	PROPN
bptjm-28	315	13	ac	ac	PROPN
bptjm-28	315	14	,	,	PUNCT
bptjm-28	315	15	gray	gray	PROPN
bptjm-28	315	16	jt	jt	PROPN
bptjm-28	315	17	,	,	PUNCT
bptjm-28	315	18	ng	ng	PROPN
bptjm-28	315	19	cy	cy	PROPN
bptjm-28	315	20	,	,	PUNCT
bptjm-28	315	21	et	et	PROPN
bptjm-28	315	22	al	al	PROPN
bptjm-28	315	23	.	.	PROPN
bptjm-28	315	24	self	self	NOUN
bptjm-28	315	25	-	-	PUNCT
bptjm-28	315	26	complementary	complementary	ADJ
bptjm-28	315	27	adeno	adeno	NOUN
bptjm-28	315	28	-	-	PUNCT
bptjm-28	315	29	associated	associate	VERB
bptjm-28	315	30	virus	virus	NOUN
bptjm-28	315	31	vectors	vector	NOUN
bptjm-28	315	32	containing	contain	VERB
bptjm-28	315	33	a	a	DET
bptjm-28	315	34	novel	novel	ADJ
bptjm-28	315	35	liver	liver	NOUN
bptjm-28	315	36	-	-	PUNCT
bptjm-28	315	37	speci	speci	NOUN
bptjm-28	315	38	�	�	PROPN
bptjm-28	315	39	c	c	NOUN
bptjm-28	315	40	human	human	ADJ
bptjm-28	315	41	factor	factor	NOUN
bptjm-28	315	42	ix	ix	ADP
bptjm-28	315	43	expression	expression	NOUN
bptjm-28	315	44	cassette	cassette	NOUN
bptjm-28	315	45	enable	enable	VERB
bptjm-28	315	46	highly	highly	ADV
bptjm-28	315	47	e	e	NOUN
bptjm-28	315	48	�	�	NOUN
bptjm-28	315	49	cient	cient	NOUN
bptjm-28	315	50	transduction	transduction	NOUN
bptjm-28	315	51	of	of	ADP
bptjm-28	315	52	murine	murine	ADJ
bptjm-28	315	53	and	and	CCONJ
bptjm-28	315	54	nonhuman	nonhuman	ADJ
bptjm-28	315	55	primate	primate	NOUN
bptjm-28	315	56	liver	liver	NOUN
bptjm-28	315	57	.	.	PUNCT
bptjm-28	316	1	blood	blood	NOUN
bptjm-28	316	2	.	.	PUNCT
bptjm-28	317	1	2006;107(7):2653	2006;107(7):2653	NUM
bptjm-28	317	2	-	-	SYM
bptjm-28	317	3	2661	2661	NUM
bptjm-28	317	4	.	.	PUNCT
bptjm-28	318	1	doi:10.1182	doi:10.1182	NOUN
bptjm-28	318	2	/	/	SYM
bptjm-28	318	3	blood-2005	blood-2005	NOUN
bptjm-28	318	4	-	-	PUNCT
bptjm-28	318	5	10	10	NUM
bptjm-28	318	6	-	-	PUNCT
bptjm-28	318	7	4035	4035	NUM
bptjm-28	318	8	25	25	NUM
bptjm-28	318	9	.	.	PUNCT
bptjm-28	318	10	breakthroughs	breakthrough	NOUN
bptjm-28	318	11	in	in	ADP
bptjm-28	318	12	gene	gene	NOUN
bptjm-28	318	13	therapy	therapy	NOUN
bptjm-28	318	14	for	for	ADP
bptjm-28	318	15	hemophilia	hemophilia	PROPN
bptjm-28	318	16	.	.	PUNCT
bptjm-28	319	1	ashpublications.org	ashpublications.org	X
bptjm-28	319	2	.	.	PUNCT
bptjm-28	320	1	https://ashpublications.org/ashclinicalnews/ne	https://ashpublications.org/ashclinicalnews/ne	PROPN
bptjm-28	320	2	ws/4099	ws/4099	VERB
bptjm-28	320	3	/	/	SYM
bptjm-28	320	4	breakthroughs	breakthrough	NOUN
bptjm-28	320	5	-	-	PUNCT
bptjm-28	320	6	in	in	ADP
bptjm-28	320	7	-	-	PUNCT
bptjm-28	320	8	gene	gene	NOUN
bptjm-28	320	9	-	-	PUNCT
bptjm-28	320	10	therapy	therapy	NOUN
bptjm-28	320	11	-	-	PUNCT
bptjm-28	320	12	forhemophilia	forhemophilia	PROPN
bptjm-28	320	13	.	.	PUNCT
bptjm-28	321	1	accessed	access	VERB
bptjm-28	321	2	march	march	PROPN
bptjm-28	321	3	29	29	NUM
bptjm-28	321	4	,	,	PUNCT
bptjm-28	321	5	2022	2022	NUM
bptjm-28	321	6	.	.	PUNCT
bptjm-28	322	1	26	26	NUM
bptjm-28	322	2	.	.	PUNCT
bptjm-28	323	1	doshi	doshi	PROPN
bptjm-28	323	2	bs	bs	PROPN
bptjm-28	323	3	,	,	PUNCT
bptjm-28	323	4	arruda	arruda	PROPN
bptjm-28	323	5	vr	vr	PROPN
bptjm-28	323	6	.	.	PROPN
bptjm-28	323	7	gene	gene	NOUN
bptjm-28	323	8	therapy	therapy	NOUN
bptjm-28	323	9	for	for	ADP
bptjm-28	323	10	hemophilia	hemophilia	PROPN
bptjm-28	323	11	:	:	PUNCT
bptjm-28	323	12	what	what	PRON
bptjm-28	323	13	does	do	AUX
bptjm-28	323	14	the	the	DET
bptjm-28	323	15	future	future	ADJ
bptjm-28	323	16	hold	hold	VERB
bptjm-28	323	17	?	?	PUNCT
bptjm-28	324	1	therapeutic	therapeutic	ADJ
bptjm-28	324	2	advances	advance	NOUN
bptjm-28	324	3	in	in	ADP
bptjm-28	324	4	hematology	hematology	NOUN
bptjm-28	324	5	.	.	PUNCT
bptjm-28	325	1	september	september	PROPN
bptjm-28	325	2	2018:273	2018:273	NUM
bptjm-28	325	3	-	-	SYM
bptjm-28	325	4	293	293	NUM
bptjm-28	325	5	.	.	PUNCT
bptjm-28	326	1	doi:10.1177/2040620718791933	doi:10.1177/2040620718791933	NOUN
bptjm-28	326	2	27	27	NUM
bptjm-28	326	3	.	.	PUNCT
bptjm-28	327	1	ran	ran	NOUN
bptjm-28	327	2	,	,	PUNCT
bptjm-28	327	3	g.	g.	PROPN
bptjm-28	327	4	,	,	PUNCT
bptjm-28	327	5	chen	chen	PROPN
bptjm-28	327	6	,	,	PUNCT
bptjm-28	327	7	x.	x.	PROPN
bptjm-28	327	8	,	,	PUNCT
bptjm-28	327	9	xie	xie	PROPN
bptjm-28	327	10	,	,	PUNCT
bptjm-28	327	11	y.	y.	PROPN
bptjm-28	327	12	,	,	PUNCT
bptjm-28	327	13	zheng	zheng	PROPN
bptjm-28	327	14	,	,	PUNCT
bptjm-28	327	15	q.	q.	PROPN
bptjm-28	327	16	,	,	PUNCT
bptjm-28	327	17	xie	xie	PROPN
bptjm-28	327	18	,	,	PUNCT
bptjm-28	327	19	j.	j.	PROPN
bptjm-28	327	20	,	,	PUNCT
bptjm-28	327	21	yu	yu	PROPN
bptjm-28	327	22	,	,	PUNCT
bptjm-28	327	23	c.	c.	NOUN
bptjm-28	327	24	,	,	PUNCT
bptjm-28	327	25	pittman	pittman	NOUN
bptjm-28	327	26	,	,	PUNCT
bptjm-28	327	27	n.	n.	NOUN
bptjm-28	327	28	,	,	PUNCT
bptjm-28	327	29	qi	qi	PROPN
bptjm-28	327	30	,	,	PUNCT
bptjm-28	327	31	s.	s.	PROPN
bptjm-28	327	32	,	,	PUNCT
bptjm-28	327	33	yu	yu	PROPN
bptjm-28	327	34	,	,	PUNCT
bptjm-28	327	35	f.	f.	PROPN
bptjm-28	327	36	x.	x.	PROPN
bptjm-28	327	37	,	,	PUNCT
bptjm-28	327	38	agbandje	agbandje	PROPN
bptjm-28	327	39	-	-	PUNCT
bptjm-28	327	40	mckenna	mckenna	PROPN
bptjm-28	327	41	,	,	PUNCT
bptjm-28	327	42	m.	m.	NOUN
bptjm-28	327	43	,	,	PUNCT
bptjm-28	327	44	srivastava	srivastava	PROPN
bptjm-28	327	45	,	,	PUNCT
bptjm-28	327	46	a.	a.	PROPN
bptjm-28	327	47	,	,	PUNCT
bptjm-28	327	48	&	&	CCONJ
bptjm-28	327	49	ling	ling	PROPN
bptjm-28	327	50	,	,	PUNCT
bptjm-28	327	51	c.	c.	PROPN
bptjm-28	327	52	(	(	PUNCT
bptjm-28	327	53	2020	2020	NUM
bptjm-28	327	54	)	)	PUNCT
bptjm-28	327	55	.	.	PUNCT
bptjm-28	328	1	site	site	NOUN
bptjm-28	328	2	-	-	PUNCT
bptjm-28	328	3	directed	direct	VERB
bptjm-28	328	4	mutagenesis	mutagenesis	NOUN
bptjm-28	328	5	improves	improve	VERB
bptjm-28	328	6	the	the	DET
bptjm-28	328	7	transduction	transduction	NOUN
bptjm-28	328	8	e	e	NOUN
bptjm-28	328	9	�	�	NOUN
bptjm-28	328	10	ciency	ciency	NOUN
bptjm-28	328	11	of	of	ADP
bptjm-28	328	12	capsid	capsid	ADJ
bptjm-28	328	13	library	library	NOUN
bptjm-28	328	14	-	-	PUNCT
bptjm-28	328	15	derived	derive	VERB
bptjm-28	328	16	recombinant	recombinant	ADJ
bptjm-28	328	17	aav	aav	NOUN
bptjm-28	328	18	vectors	vector	NOUN
bptjm-28	328	19	.	.	PUNCT
bptjm-28	329	1	molecular	molecular	ADJ
bptjm-28	329	2	therapy	therapy	NOUN
bptjm-28	329	3	.	.	PUNCT
bptjm-28	330	1	methods	method	NOUN
bptjm-28	330	2	&	&	CCONJ
bptjm-28	330	3	clinical	clinical	ADJ
bptjm-28	330	4	development	development	NOUN
bptjm-28	330	5	,	,	PUNCT
bptjm-28	330	6	17	17	NUM
bptjm-28	330	7	,	,	PUNCT
bptjm-28	330	8	545–555	545–555	NUM
bptjm-28	330	9	.	.	PUNCT
bptjm-28	331	1	https://doi.org/10.1016/j.omtm.2020.03.007	https://doi.org/10.1016/j.omtm.2020.03.007	PROPN
bptjm-28	331	2	28	28	NUM
bptjm-28	331	3	.	.	PUNCT
bptjm-28	332	1	maheshri	maheshri	PROPN
bptjm-28	332	2	,	,	PUNCT
bptjm-28	332	3	n.	n.	NOUN
bptjm-28	332	4	,	,	PUNCT
bptjm-28	332	5	koerber	koerber	PROPN
bptjm-28	332	6	,	,	PUNCT
bptjm-28	332	7	j.	j.	PROPN
bptjm-28	332	8	,	,	PUNCT
bptjm-28	332	9	kaspar	kaspar	PROPN
bptjm-28	332	10	,	,	PUNCT
bptjm-28	332	11	b.	b.	PROPN
bptjm-28	332	12	et	et	PROPN
bptjm-28	332	13	al	al	PROPN
bptjm-28	332	14	.	.	PROPN
bptjm-28	332	15	directed	direct	VERB
bptjm-28	332	16	evolution	evolution	NOUN
bptjm-28	332	17	of	of	ADP
bptjm-28	332	18	adeno	adeno	NOUN
bptjm-28	332	19	-	-	PUNCT
bptjm-28	332	20	associated	associate	VERB
bptjm-28	332	21	virus	virus	NOUN
bptjm-28	332	22	yields	yield	NOUN
bptjm-28	332	23	enhanced	enhance	VERB
bptjm-28	332	24	gene	gene	NOUN
bptjm-28	332	25	delivery	delivery	NOUN
bptjm-28	332	26	vectors	vector	NOUN
bptjm-28	332	27	.	.	PUNCT
bptjm-28	333	1	nat	nat	PROPN
bptjm-28	333	2	biotechnol	biotechnol	PROPN
bptjm-28	333	3	24	24	NUM
bptjm-28	333	4	,	,	PUNCT
bptjm-28	333	5	198–204	198–204	NUM
bptjm-28	333	6	(	(	PUNCT
bptjm-28	333	7	2006	2006	NUM
bptjm-28	333	8	)	)	PUNCT
bptjm-28	333	9	.	.	PUNCT
bptjm-28	334	1	https://doi.org/10.1038/nbt1182	https://doi.org/10.1038/nbt1182	PROPN
bptjm-28	334	2	29	29	NUM
bptjm-28	334	3	.	.	PUNCT
bptjm-28	335	1	gouw	gouw	PROPN
bptjm-28	335	2	sc	sc	PROPN
bptjm-28	335	3	,	,	PUNCT
bptjm-28	335	4	van	van	PROPN
bptjm-28	335	5	den	den	PROPN
bptjm-28	335	6	berg	berg	PROPN
bptjm-28	335	7	hm	hm	PROPN
bptjm-28	335	8	.	.	PUNCT
bptjm-28	336	1	the	the	DET
bptjm-28	336	2	multifactorial	multifactorial	ADJ
bptjm-28	336	3	etiology	etiology	NOUN
bptjm-28	336	4	of	of	ADP
bptjm-28	336	5	inhibitor	inhibitor	NOUN
bptjm-28	336	6	berkeley	berkeley	PROPN
bptjm-28	336	7	pharma	pharma	PROPN
bptjm-28	336	8	tech	tech	NOUN
bptjm-28	336	9	journal	journal	NOUN
bptjm-28	336	10	of	of	ADP
bptjm-28	336	11	medicine	medicine	NOUN
bptjm-28	336	12	|	|	ADV
bptjm-28	336	13	136	136	NUM
bptjm-28	336	14	development	development	NOUN
bptjm-28	336	15	in	in	ADP
bptjm-28	336	16	hemophilia	hemophilia	PROPN
bptjm-28	336	17	:	:	PUNCT
bptjm-28	336	18	genetics	genetic	NOUN
bptjm-28	336	19	and	and	CCONJ
bptjm-28	336	20	environment	environment	NOUN
bptjm-28	336	21	.	.	PUNCT
bptjm-28	337	1	semin	semin	PROPN
bptjm-28	337	2	thromb	thromb	PROPN
bptjm-28	337	3	hemost	hemost	PROPN
bptjm-28	337	4	.	.	PUNCT
bptjm-28	338	1	2009;35(8):723	2009;35(8):723	PROPN
bptjm-28	338	2	-	-	PUNCT
bptjm-28	338	3	734	734	NUM
bptjm-28	338	4	.	.	PUNCT
bptjm-28	339	1	doi:10.1055	doi:10.1055	NOUN
bptjm-28	339	2	/	/	SYM
bptjm-28	339	3	s-0029	s-0029	PROPN
bptjm-28	339	4	-	-	PUNCT
bptjm-28	339	5	1245105	1245105	NUM
bptjm-28	339	6	30	30	NUM
bptjm-28	339	7	.	.	PUNCT
bptjm-28	340	1	witmer	witmer	PROPN
bptjm-28	340	2	c	c	PROPN
bptjm-28	340	3	,	,	PUNCT
bptjm-28	340	4	young	young	ADJ
bptjm-28	340	5	g.	g.	NOUN
bptjm-28	340	6	factor	factor	NOUN
bptjm-28	340	7	viii	viii	NOUN
bptjm-28	340	8	inhibitors	inhibitor	NOUN
bptjm-28	340	9	in	in	ADP
bptjm-28	340	10	hemophilia	hemophilia	PROPN
bptjm-28	340	11	a	a	DET
bptjm-28	340	12	:	:	PUNCT
bptjm-28	340	13	rationale	rationale	NOUN
bptjm-28	340	14	and	and	CCONJ
bptjm-28	340	15	latest	late	ADJ
bptjm-28	340	16	evidence	evidence	NOUN
bptjm-28	340	17	.	.	PUNCT
bptjm-28	341	1	ther	ther	VERB
bptjm-28	341	2	adv	adv	PROPN
bptjm-28	341	3	hematol	hematol	NOUN
bptjm-28	341	4	.	.	PUNCT
bptjm-28	342	1	2013;4(1):59	2013;4(1):59	NUM
bptjm-28	342	2	-	-	SYM
bptjm-28	342	3	72	72	NUM
bptjm-28	342	4	.	.	PUNCT
bptjm-28	343	1	doi:10.1177/2040620712464509	doi:10.1177/2040620712464509	NOUN
bptjm-28	343	2	31	31	NUM
bptjm-28	343	3	.	.	PUNCT
bptjm-28	344	1	lorenzo	lorenzo	PROPN
bptjm-28	344	2	ji	ji	PROPN
bptjm-28	344	3	,	,	PUNCT
bptjm-28	344	4	lópez	lópez	PROPN
bptjm-28	344	5	a	a	PRON
bptjm-28	344	6	,	,	PUNCT
bptjm-28	344	7	altisent	altisent	NOUN
bptjm-28	344	8	c	c	NOUN
bptjm-28	344	9	,	,	PUNCT
bptjm-28	344	10	aznar	aznar	PROPN
bptjm-28	344	11	ja	ja	PROPN
bptjm-28	344	12	.	.	PUNCT
bptjm-28	344	13	incidence	incidence	NOUN
bptjm-28	344	14	of	of	ADP
bptjm-28	344	15	factor	factor	NOUN
bptjm-28	344	16	viii	viii	NOUN
bptjm-28	344	17	inhibitors	inhibitor	NOUN
bptjm-28	344	18	in	in	ADP
bptjm-28	344	19	severe	severe	ADJ
bptjm-28	344	20	haemophilia	haemophilia	NOUN
bptjm-28	344	21	:	:	PUNCT
bptjm-28	344	22	the	the	DET
bptjm-28	344	23	importance	importance	NOUN
bptjm-28	344	24	of	of	ADP
bptjm-28	344	25	patient	patient	ADJ
bptjm-28	344	26	age	age	NOUN
bptjm-28	344	27	.	.	PUNCT
bptjm-28	345	1	british	british	PROPN
bptjm-28	345	2	j	j	PROPN
bptjm-28	345	3	haematology	haematology	PROPN
bptjm-28	345	4	.	.	PUNCT
bptjm-28	346	1	2001;113(3):600	2001;113(3):600	NUM
bptjm-28	346	2	-	-	SYM
bptjm-28	346	3	603	603	NUM
bptjm-28	346	4	.	.	PUNCT
bptjm-28	347	1	doi:10.1046	doi:10.1046	ADJ
bptjm-28	347	2	/	/	SYM
bptjm-28	347	3	j.1365	j.1365	NOUN
bptjm-28	347	4	-	-	PUNCT
bptjm-28	347	5	2141.2001.02828.x	2141.2001.02828.x	NUM
bptjm-28	347	6	32	32	NUM
bptjm-28	347	7	.	.	PUNCT
bptjm-28	348	1	gouw	gouw	PROPN
bptjm-28	348	2	sc	sc	PROPN
bptjm-28	348	3	,	,	PUNCT
bptjm-28	348	4	van	van	PROPN
bptjm-28	348	5	der	der	PROPN
bptjm-28	348	6	bom	bom	PROPN
bptjm-28	348	7	jg	jg	PROPN
bptjm-28	348	8	,	,	PUNCT
bptjm-28	348	9	marijke	marijke	PROPN
bptjm-28	348	10	van	van	PROPN
bptjm-28	348	11	den	den	PROPN
bptjm-28	348	12	berg	berg	PROPN
bptjm-28	348	13	h.	h.	PROPN
bptjm-28	348	14	treatment	treatment	PROPN
bptjm-28	348	15	-	-	PUNCT
bptjm-28	348	16	related	relate	VERB
bptjm-28	348	17	risk	risk	NOUN
bptjm-28	348	18	factors	factor	NOUN
bptjm-28	348	19	of	of	ADP
bptjm-28	348	20	inhibitor	inhibitor	NOUN
bptjm-28	348	21	development	development	NOUN
bptjm-28	348	22	in	in	ADP
bptjm-28	348	23	previously	previously	ADV
bptjm-28	348	24	untreated	untreated	ADJ
bptjm-28	348	25	patients	patient	NOUN
bptjm-28	348	26	with	with	ADP
bptjm-28	348	27	hemophilia	hemophilia	PROPN
bptjm-28	349	1	a	a	PRON
bptjm-28	349	2	:	:	PUNCT
bptjm-28	349	3	the	the	DET
bptjm-28	349	4	canal	canal	NOUN
bptjm-28	349	5	cohort	cohort	NOUN
bptjm-28	349	6	study	study	NOUN
bptjm-28	349	7	.	.	PUNCT
bptjm-28	350	1	blood	blood	NOUN
bptjm-28	350	2	.	.	PUNCT
bptjm-28	351	1	2007;109(11):4648	2007;109(11):4648	NUM
bptjm-28	351	2	-	-	SYM
bptjm-28	351	3	4654	4654	NUM
bptjm-28	351	4	.	.	PUNCT
bptjm-28	352	1	doi:10.1182	doi:10.1182	NOUN
bptjm-28	352	2	/	/	SYM
bptjm-28	352	3	blood-2006	blood-2006	ADJ
bptjm-28	352	4	-	-	PUNCT
bptjm-28	352	5	11	11	NUM
bptjm-28	352	6	-	-	PUNCT
bptjm-28	352	7	056291	056291	NUM
bptjm-28	352	8	33	33	NUM
bptjm-28	352	9	.	.	PUNCT
bptjm-28	353	1	louis	louis	PROPN
bptjm-28	353	2	jeune	jeune	PROPN
bptjm-28	353	3	v	v	PROPN
bptjm-28	353	4	,	,	PUNCT
bptjm-28	353	5	joergensen	joergensen	PROPN
bptjm-28	353	6	ja	ja	PROPN
bptjm-28	353	7	,	,	PUNCT
bptjm-28	353	8	hajjar	hajjar	PROPN
bptjm-28	353	9	rj	rj	PROPN
bptjm-28	353	10	,	,	PUNCT
bptjm-28	353	11	weber	weber	PROPN
bptjm-28	353	12	t.	t.	PROPN
bptjm-28	353	13	pre	pre	PROPN
bptjm-28	353	14	-	-	ADJ
bptjm-28	353	15	existing	exist	VERB
bptjm-28	353	16	anti	anti	ADJ
bptjm-28	353	17	-	-	ADJ
bptjm-28	353	18	adeno	adeno	ADJ
bptjm-28	353	19	-	-	PUNCT
bptjm-28	353	20	associated	associate	VERB
bptjm-28	353	21	virus	virus	NOUN
bptjm-28	353	22	antibodies	antibodie	VERB
bptjm-28	353	23	as	as	ADP
bptjm-28	353	24	a	a	DET
bptjm-28	353	25	challenge	challenge	NOUN
bptjm-28	353	26	in	in	ADP
bptjm-28	353	27	aav	aav	NOUN
bptjm-28	353	28	gene	gene	NOUN
bptjm-28	353	29	therapy	therapy	NOUN
bptjm-28	353	30	.	.	PUNCT
bptjm-28	354	1	hum	hum	PROPN
bptjm-28	354	2	gene	gene	NOUN
bptjm-28	354	3	ther	ther	PROPN
bptjm-28	354	4	methods	method	NOUN
bptjm-28	354	5	.	.	PUNCT
bptjm-28	355	1	2013;24(2):59	2013;24(2):59	NUM
bptjm-28	355	2	-	-	SYM
bptjm-28	355	3	67	67	NUM
bptjm-28	355	4	.	.	PUNCT
bptjm-28	356	1	doi:10.1089	doi:10.1089	PROPN
bptjm-28	356	2	/	/	SYM
bptjm-28	356	3	hgtb.2012.243	hgtb.2012.243	PROPN
bptjm-28	356	4	34	34	NUM
bptjm-28	356	5	.	.	PUNCT
bptjm-28	357	1	boutin	boutin	PROPN
bptjm-28	357	2	s	s	PROPN
bptjm-28	357	3	,	,	PUNCT
bptjm-28	357	4	monteilhet	monteilhet	PROPN
bptjm-28	357	5	v	v	NOUN
bptjm-28	357	6	,	,	PUNCT
bptjm-28	357	7	veron	veron	PROPN
bptjm-28	357	8	p	p	X
bptjm-28	357	9	,	,	PUNCT
bptjm-28	357	10	et	et	PROPN
bptjm-28	357	11	al	al	PROPN
bptjm-28	357	12	.	.	PUNCT
bptjm-28	358	1	prevalence	prevalence	NOUN
bptjm-28	358	2	of	of	ADP
bptjm-28	358	3	serum	serum	NOUN
bptjm-28	358	4	igg	igg	PROPN
bptjm-28	358	5	and	and	CCONJ
bptjm-28	358	6	neutralizing	neutralize	VERB
bptjm-28	358	7	factors	factor	NOUN
bptjm-28	358	8	against	against	ADP
bptjm-28	358	9	adeno	adeno	NOUN
bptjm-28	358	10	-	-	PUNCT
bptjm-28	358	11	associated	associate	VERB
bptjm-28	358	12	virus	virus	NOUN
bptjm-28	358	13	(	(	PUNCT
bptjm-28	358	14	aav	aav	NOUN
bptjm-28	358	15	)	)	PUNCT
bptjm-28	358	16	types	type	NOUN
bptjm-28	358	17	1	1	NUM
bptjm-28	358	18	,	,	PUNCT
bptjm-28	358	19	2	2	NUM
bptjm-28	358	20	,	,	PUNCT
bptjm-28	358	21	5	5	NUM
bptjm-28	358	22	,	,	PUNCT
bptjm-28	358	23	6	6	NUM
bptjm-28	358	24	,	,	PUNCT
bptjm-28	358	25	8	8	NUM
bptjm-28	358	26	,	,	PUNCT
bptjm-28	358	27	and	and	CCONJ
bptjm-28	358	28	9	9	NUM
bptjm-28	358	29	in	in	ADP
bptjm-28	358	30	the	the	DET
bptjm-28	358	31	healthy	healthy	ADJ
bptjm-28	358	32	population	population	NOUN
bptjm-28	358	33	:	:	PUNCT
bptjm-28	358	34	implications	implication	NOUN
bptjm-28	358	35	for	for	ADP
bptjm-28	358	36	gene	gene	NOUN
bptjm-28	358	37	therapy	therapy	NOUN
bptjm-28	358	38	using	use	VERB
bptjm-28	358	39	aav	aav	NOUN
bptjm-28	358	40	vectors	vector	NOUN
bptjm-28	358	41	.	.	PUNCT
bptjm-28	359	1	hum	hum	PROPN
bptjm-28	359	2	gene	gene	PROPN
bptjm-28	359	3	ther	ther	ADV
bptjm-28	359	4	.	.	PUNCT
bptjm-28	360	1	2010;21(6):704	2010;21(6):704	PROPN
bptjm-28	360	2	-	-	SYM
bptjm-28	360	3	712	712	NUM
bptjm-28	360	4	.	.	PUNCT
bptjm-28	360	5	doi:10.1089	doi:10.1089	NOUN
bptjm-28	360	6	/	/	SYM
bptjm-28	360	7	hum.2009.182	hum.2009.182	PROPN
bptjm-28	360	8	35	35	NUM
bptjm-28	360	9	.	.	PUNCT
bptjm-28	361	1	patel	patel	PROPN
bptjm-28	361	2	sr	sr	PROPN
bptjm-28	361	3	,	,	PUNCT
bptjm-28	361	4	lundgren	lundgren	PROPN
bptjm-28	361	5	ts	ts	PROPN
bptjm-28	361	6	,	,	PUNCT
bptjm-28	361	7	spencer	spencer	PROPN
bptjm-28	361	8	ht	ht	PROPN
bptjm-28	361	9	,	,	PUNCT
bptjm-28	361	10	doering	doere	VERB
bptjm-28	361	11	cb	cb	PROPN
bptjm-28	361	12	.	.	PUNCT
bptjm-28	362	1	the	the	DET
bptjm-28	362	2	immune	immune	ADJ
bptjm-28	362	3	response	response	NOUN
bptjm-28	362	4	to	to	ADP
bptjm-28	362	5	the	the	DET
bptjm-28	362	6	fviii	fviii	NOUN
bptjm-28	362	7	gene	gene	NOUN
bptjm-28	362	8	therapy	therapy	NOUN
bptjm-28	362	9	in	in	ADP
bptjm-28	362	10	preclinical	preclinical	ADJ
bptjm-28	362	11	models	model	NOUN
bptjm-28	362	12	.	.	PUNCT
bptjm-28	363	1	front	front	ADJ
bptjm-28	363	2	immun	immun	PROPN
bptjm-28	363	3	.	.	PUNCT
bptjm-28	364	1	2020;11	2020;11	NUM
bptjm-28	364	2	.	.	PUNCT
bptjm-28	365	1	doi:10.3389/	doi:10.3389/	PROPN
bptjm-28	365	2	�	�	PROPN
bptjm-28	365	3	mmu.2020.00494	mmu.2020.00494	PRON
bptjm-28	365	4	36	36	NUM
bptjm-28	365	5	.	.	PUNCT
bptjm-28	366	1	song	song	PROPN
bptjm-28	366	2	s	s	PROPN
bptjm-28	366	3	,	,	PUNCT
bptjm-28	366	4	lyle	lyle	PROPN
bptjm-28	366	5	mj	mj	PROPN
bptjm-28	366	6	,	,	PUNCT
bptjm-28	366	7	noble	noble	ADJ
bptjm-28	366	8	-	-	PUNCT
bptjm-28	366	9	vranish	vranish	ADJ
bptjm-28	366	10	ml	ml	PROPN
bptjm-28	366	11	,	,	PUNCT
bptjm-28	366	12	et	et	PROPN
bptjm-28	366	13	al	al	PROPN
bptjm-28	366	14	.	.	PROPN
bptjm-28	366	15	ultrasound	ultrasound	PROPN
bptjm-28	366	16	-	-	PUNCT
bptjm-28	366	17	mediated	mediate	VERB
bptjm-28	366	18	gene	gene	NOUN
bptjm-28	366	19	delivery	delivery	NOUN
bptjm-28	366	20	of	of	ADP
bptjm-28	366	21	factor	factor	NOUN
bptjm-28	366	22	viii	viii	NOUN
bptjm-28	366	23	plasmids	plasmid	NOUN
bptjm-28	366	24	for	for	ADP
bptjm-28	366	25	hemophilia	hemophilia	NOUN
bptjm-28	366	26	a	a	DET
bptjm-28	366	27	gene	gene	NOUN
bptjm-28	366	28	therapy	therapy	NOUN
bptjm-28	366	29	in	in	ADP
bptjm-28	366	30	mice	mouse	NOUN
bptjm-28	366	31	.	.	PUNCT
bptjm-28	367	1	mol	mol	ADP
bptjm-28	367	2	ther	ther	ADV
bptjm-28	367	3	nucleic	nucleic	ADJ
bptjm-28	367	4	acids	acid	NOUN
bptjm-28	367	5	.	.	PUNCT
bptjm-28	368	1	2022;27:916	2022;27:916	NUM
bptjm-28	368	2	-	-	SYM
bptjm-28	368	3	926	926	NUM
bptjm-28	368	4	.	.	PUNCT
bptjm-28	369	1	published	publish	VERB
bptjm-28	369	2	2022	2022	NUM
bptjm-28	369	3	jan	jan	PROPN
bptjm-28	369	4	10	10	NUM
bptjm-28	369	5	.	.	PUNCT
bptjm-28	370	1	doi:10.1016	doi:10.1016	PROPN
bptjm-28	370	2	/	/	SYM
bptjm-28	370	3	j.omtn.2022.01.006	j.omtn.2022.01.006	PROPN
bptjm-28	370	4	.	.	PUNCT
bptjm-28	371	1	37	37	NUM
bptjm-28	371	2	.	.	PUNCT
bptjm-28	371	3	ultrasound	ultrasound	NOUN
bptjm-28	371	4	-	-	PUNCT
bptjm-28	371	5	mediated	mediate	VERB
bptjm-28	371	6	gene	gene	NOUN
bptjm-28	371	7	delivery	delivery	NOUN
bptjm-28	371	8	of	of	ADP
bptjm-28	371	9	factor	factor	NOUN
bptjm-28	371	10	viii	viii	NOUN
bptjm-28	371	11	plasmids	plasmid	NOUN
bptjm-28	371	12	for	for	ADP
bptjm-28	371	13	hemophilia	hemophilia	NOUN
bptjm-28	371	14	a	a	DET
bptjm-28	371	15	gene	gene	NOUN
bptjm-28	371	16	therapy	therapy	NOUN
bptjm-28	371	17	in	in	ADP
bptjm-28	371	18	mice	mouse	NOUN
bptjm-28	371	19	,	,	PUNCT
bptjm-28	371	20	mol	mol	ADP
bptjm-28	371	21	ther	ther	ADV
bptjm-28	371	22	nucleic	nucleic	ADJ
bptjm-28	371	23	acids	acid	NOUN
bptjm-28	371	24	,	,	PUNCT
bptjm-28	371	25	volume	volume	NOUN
bptjm-28	371	26	27	27	NUM
bptjm-28	371	27	,	,	PUNCT
bptjm-28	371	28	2022	2022	NUM
bptjm-28	371	29	,	,	PUNCT
bptjm-28	371	30	pages	page	NOUN
bptjm-28	371	31	916	916	NUM
bptjm-28	371	32	-	-	SYM
bptjm-28	371	33	926	926	NUM
bptjm-28	371	34	,	,	PUNCT
bptjm-28	371	35	issn	issn	PROPN
bptjm-28	371	36	2162	2162	NUM
bptjm-28	371	37	-	-	SYM
bptjm-28	371	38	2531	2531	NUM
bptjm-28	371	39	,	,	PUNCT
bptjm-28	371	40	https://doi.org/10.1016/j.omtn.2022.01.006	https://doi.org/10.1016/j.omtn.2022.01.006	ADJ
bptjm-28	371	41	.	.	PUNCT
bptjm-28	372	1	38	38	NUM
bptjm-28	372	2	.	.	PUNCT
bptjm-28	372	3	vandendruessche	vandendruessche	PROPN
bptjm-28	372	4	t	t	PROPN
bptjm-28	372	5	,	,	PUNCT
bptjm-28	372	6	thorrez	thorrez	PROPN
bptjm-28	372	7	l	l	NOUN
bptjm-28	372	8	,	,	PUNCT
bptjm-28	372	9	acosta	acosta	PROPN
bptjm-28	372	10	-	-	PUNCT
bptjm-28	372	11	sanchez	sanchez	PROPN
bptjm-28	372	12	a	a	PROPN
bptjm-28	372	13	,	,	PUNCT
bptjm-28	372	14	et	et	PROPN
bptjm-28	372	15	al	al	PROPN
bptjm-28	372	16	.	.	PUNCT
bptjm-28	373	1	e	e	X
bptjm-28	373	2	�	�	PROPN
bptjm-28	373	3	cacy	cacy	NOUN
bptjm-28	373	4	and	and	CCONJ
bptjm-28	373	5	safety	safety	NOUN
bptjm-28	373	6	of	of	ADP
bptjm-28	373	7	adeno	adeno	NOUN
bptjm-28	373	8	-	-	PUNCT
bptjm-28	373	9	associated	associate	VERB
bptjm-28	373	10	viral	viral	ADJ
bptjm-28	373	11	vectors	vector	NOUN
bptjm-28	373	12	based	base	VERB
bptjm-28	373	13	on	on	ADP
bptjm-28	373	14	serotype	serotype	ADJ
bptjm-28	373	15	8	8	NUM
bptjm-28	373	16	and	and	CCONJ
bptjm-28	373	17	9	9	NUM
bptjm-28	373	18	vs.	vs.	ADP
bptjm-28	373	19	lentiviral	lentiviral	ADJ
bptjm-28	373	20	vectors	vector	NOUN
bptjm-28	373	21	for	for	ADP
bptjm-28	373	22	hemophilia	hemophilia	PROPN
bptjm-28	373	23	b	b	PROPN
bptjm-28	373	24	gene	gene	NOUN
bptjm-28	373	25	therapy	therapy	NOUN
bptjm-28	373	26	.	.	PUNCT
bptjm-28	374	1	j	j	PROPN
bptjm-28	374	2	thromb	thromb	PROPN
bptjm-28	374	3	haemost	haemost	VERB
bptjm-28	374	4	.	.	PUNCT
bptjm-28	375	1	2006;5(1):16	2006;5(1):16	NUM
bptjm-28	375	2	-	-	SYM
bptjm-28	375	3	24	24	NUM
bptjm-28	375	4	.	.	PUNCT
bptjm-28	376	1	doi:10.1111	doi:10.1111	ADJ
bptjm-28	376	2	/	/	SYM
bptjm-28	376	3	j.1538	j.1538	NOUN
bptjm-28	376	4	-	-	PUNCT
bptjm-28	376	5	7836.2006.02220.x	7836.2006.02220.x	NOUN
bptjm-28	376	6	39	39	NUM
bptjm-28	376	7	.	.	PUNCT
bptjm-28	377	1	samelson	samelson	ADJ
bptjm-28	377	2	-	-	PUNCT
bptjm-28	377	3	jones	jones	PROPN
bptjm-28	377	4	bj	bj	PROPN
bptjm-28	377	5	,	,	PUNCT
bptjm-28	377	6	arruda	arruda	PROPN
bptjm-28	377	7	vr	vr	PROPN
bptjm-28	377	8	.	.	PROPN
bptjm-28	377	9	protein	protein	NOUN
bptjm-28	377	10	-	-	PUNCT
bptjm-28	377	11	engineered	engineer	VERB
bptjm-28	377	12	coagulation	coagulation	NOUN
bptjm-28	377	13	factors	factor	NOUN
bptjm-28	377	14	for	for	ADP
bptjm-28	377	15	hemophilia	hemophilia	NOUN
bptjm-28	377	16	gene	gene	NOUN
bptjm-28	377	17	therapy	therapy	NOUN
bptjm-28	377	18	.	.	PUNCT
bptjm-28	378	1	mol	mol	ADP
bptjm-28	378	2	ther	ther	PROPN
bptjm-28	378	3	methods	method	NOUN
bptjm-28	378	4	clin	clin	PROPN
bptjm-28	378	5	dev	dev	PROPN
bptjm-28	378	6	.	.	PUNCT
bptjm-28	379	1	2018;12:184	2018;12:184	NUM
bptjm-28	379	2	-	-	SYM
bptjm-28	379	3	201	201	NUM
bptjm-28	379	4	.	.	PUNCT
bptjm-28	380	1	published	publish	VERB
bptjm-28	380	2	2018	2018	NUM
bptjm-28	380	3	dec	dec	PROPN
bptjm-28	380	4	31	31	NUM
bptjm-28	380	5	.	.	PUNCT
bptjm-28	381	1	doi:10.1016	doi:10.1016	PROPN
bptjm-28	381	2	/	/	SYM
bptjm-28	381	3	j.omtm.2018.12.007	j.omtm.2018.12.007	PROPN
bptjm-28	381	4	40	40	NUM
bptjm-28	381	5	.	.	PUNCT
bptjm-28	382	1	tosolini	tosolini	PROPN
bptjm-28	382	2	ap	ap	PROPN
bptjm-28	382	3	and	and	CCONJ
bptjm-28	382	4	sleigh	sleigh	PROPN
bptjm-28	382	5	jn	jn	PROPN
bptjm-28	382	6	(	(	PUNCT
bptjm-28	382	7	2020	2020	NUM
bptjm-28	382	8	)	)	PUNCT
bptjm-28	382	9	intramuscular	intramuscular	ADJ
bptjm-28	382	10	delivery	delivery	NOUN
bptjm-28	382	11	of	of	ADP
bptjm-28	382	12	gene	gene	NOUN
bptjm-28	382	13	therapy	therapy	NOUN
bptjm-28	382	14	for	for	ADP
bptjm-28	382	15	targeting	target	VERB
bptjm-28	382	16	the	the	DET
bptjm-28	382	17	nervous	nervous	ADJ
bptjm-28	382	18	system	system	NOUN
bptjm-28	382	19	.	.	PUNCT
bptjm-28	383	1	front	front	NOUN
bptjm-28	383	2	.	.	PUNCT
bptjm-28	384	1	mol	mol	PROPN
bptjm-28	384	2	.	.	PROPN
bptjm-28	384	3	neurosci	neurosci	PROPN
bptjm-28	384	4	.	.	PUNCT
bptjm-28	385	1	13:129	13:129	NUM
bptjm-28	385	2	.	.	PUNCT
bptjm-28	386	1	doi	doi	NOUN
bptjm-28	386	2	:	:	PUNCT
bptjm-28	386	3	10.3389	10.3389	NUM
bptjm-28	386	4	/	/	SYM
bptjm-28	386	5	fnmol.2020.00129	fnmol.2020.00129	NUM
bptjm-28	386	6	41	41	NUM
bptjm-28	386	7	.	.	PUNCT
bptjm-28	387	1	wang	wang	PROPN
bptjm-28	387	2	,	,	PUNCT
bptjm-28	387	3	z.	z.	PROPN
bptjm-28	387	4	,	,	PUNCT
bptjm-28	387	5	ma	ma	PROPN
bptjm-28	387	6	,	,	PUNCT
bptjm-28	387	7	hi	hi	PROPN
bptjm-28	387	8	.	.	PROPN
bptjm-28	387	9	,	,	PUNCT
bptjm-28	387	10	li	li	PROPN
bptjm-28	387	11	,	,	PUNCT
bptjm-28	387	12	j.	j.	PROPN
bptjm-28	387	13	et	et	PROPN
bptjm-28	387	14	al	al	PROPN
bptjm-28	387	15	.	.	PROPN
bptjm-28	387	16	rapid	rapid	ADJ
bptjm-28	387	17	and	and	CCONJ
bptjm-28	387	18	highly	highly	ADV
bptjm-28	387	19	e	e	NOUN
bptjm-28	387	20	�	�	NOUN
bptjm-28	387	21	cient	cient	NOUN
bptjm-28	387	22	transduction	transduction	NOUN
bptjm-28	387	23	by	by	ADP
bptjm-28	387	24	double	double	ADJ
bptjm-28	387	25	-	-	PUNCT
bptjm-28	387	26	stranded	strand	VERB
bptjm-28	387	27	adeno	adeno	NOUN
bptjm-28	387	28	-	-	PUNCT
bptjm-28	387	29	associated	associate	VERB
bptjm-28	387	30	virus	virus	NOUN
bptjm-28	387	31	vectors	vector	NOUN
bptjm-28	387	32	in	in	ADP
bptjm-28	387	33	vitro	vitro	X
bptjm-28	387	34	and	and	CCONJ
bptjm-28	387	35	in	in	ADP
bptjm-28	387	36	vivo	vivo	NOUN
bptjm-28	387	37	.	.	PUNCT
bptjm-28	388	1	gene	gene	NOUN
bptjm-28	388	2	ther	ther	ADV
bptjm-28	388	3	10	10	NUM
bptjm-28	388	4	,	,	PUNCT
bptjm-28	388	5	2105–2111	2105–2111	NUM
bptjm-28	388	6	(	(	PUNCT
bptjm-28	388	7	2003	2003	NUM
bptjm-28	388	8	)	)	PUNCT
bptjm-28	388	9	.	.	PUNCT
bptjm-28	389	1	https://doi.org/10.1038/sj.gt.3302133	https://doi.org/10.1038/sj.gt.3302133	PROPN
bptjm-28	389	2	42	42	NUM
bptjm-28	389	3	.	.	PUNCT
bptjm-28	390	1	paul	paul	PROPN
bptjm-28	390	2	batty	batty	PROPN
bptjm-28	390	3	,	,	PUNCT
bptjm-28	390	4	david	david	PROPN
bptjm-28	390	5	lillicrap	lillicrap	PROPN
bptjm-28	390	6	,	,	PUNCT
bptjm-28	390	7	advances	advance	NOUN
bptjm-28	390	8	and	and	CCONJ
bptjm-28	390	9	challenges	challenge	NOUN
bptjm-28	390	10	for	for	ADP
bptjm-28	390	11	hemophilia	hemophilia	NOUN
bptjm-28	390	12	gene	gene	NOUN
bptjm-28	390	13	therapy	therapy	NOUN
bptjm-28	390	14	,	,	PUNCT
bptjm-28	390	15	hum	hum	PROPN
bptjm-28	390	16	berkeley	berkeley	PROPN
bptjm-28	390	17	pharma	pharma	PROPN
bptjm-28	390	18	tech	tech	PROPN
bptjm-28	390	19	journal	journal	NOUN
bptjm-28	390	20	of	of	ADP
bptjm-28	390	21	medicine	medicine	NOUN
bptjm-28	390	22	|	|	ADV
bptjm-28	390	23	137	137	NUM
bptjm-28	390	24	mol	mol	ADP
bptjm-28	390	25	gen	gen	PROPN
bptjm-28	390	26	,	,	PUNCT
bptjm-28	390	27	volume	volume	NOUN
bptjm-28	390	28	28	28	NUM
bptjm-28	390	29	,	,	PUNCT
bptjm-28	390	30	issue	issue	NOUN
bptjm-28	390	31	r1	r1	PROPN
bptjm-28	390	32	,	,	PUNCT
bptjm-28	390	33	october	october	PROPN
bptjm-28	390	34	2019	2019	NUM
bptjm-28	390	35	,	,	PUNCT
bptjm-28	390	36	pages	page	NOUN
bptjm-28	390	37	r95	r95	VERB
bptjm-28	390	38	–	–	PUNCT
bptjm-28	390	39	r101	r101	PROPN
bptjm-28	390	40	,	,	PUNCT
bptjm-28	390	41	https://doi.org/10.1093/hmg/ddz157	https://doi.org/10.1093/hmg/ddz157	PROPN
bptjm-28	390	42	43	43	NUM
bptjm-28	390	43	.	.	PUNCT
bptjm-28	391	1	batty	batty	PROPN
bptjm-28	391	2	,	,	PUNCT
bptjm-28	391	3	paul	paul	PROPN
bptjm-28	391	4	;	;	PUNCT
bptjm-28	391	5	lillicrap	lillicrap	PROPN
bptjm-28	391	6	,	,	PUNCT
bptjm-28	391	7	david	david	PROPN
bptjm-28	391	8	hemophilia	hemophilia	PROPN
bptjm-28	391	9	gene	gene	NOUN
bptjm-28	391	10	therapy	therapy	NOUN
bptjm-28	391	11	:	:	PUNCT
bptjm-28	391	12	approaching	approach	VERB
bptjm-28	391	13	the	the	DET
bptjm-28	391	14	first	first	ADJ
bptjm-28	391	15	licensed	licensed	ADJ
bptjm-28	391	16	product	product	NOUN
bptjm-28	391	17	,	,	PUNCT
bptjm-28	391	18	hemasphere	hemasphere	ADV
bptjm-28	391	19	:	:	PUNCT
bptjm-28	391	20	march	march	NOUN
bptjm-28	391	21	2021	2021	NUM
bptjm-28	391	22	volume	volume	NOUN
bptjm-28	391	23	5	5	NUM
bptjm-28	391	24	issue	issue	NOUN
bptjm-28	391	25	3	3	NUM
bptjm-28	391	26	p	p	X
bptjm-28	391	27	e540	e540	PROPN
bptjm-28	391	28	doi	doi	NOUN
bptjm-28	391	29	:	:	PUNCT
bptjm-28	391	30	10.1097	10.1097	NUM
bptjm-28	391	31	/	/	SYM
bptjm-28	391	32	hs9.0000000000000540	hs9.0000000000000540	PROPN
bptjm-28	391	33	44	44	NUM
bptjm-28	391	34	.	.	PUNCT
bptjm-28	391	35	ohmori	ohmori	PROPN
bptjm-28	391	36	,	,	PUNCT
bptjm-28	391	37	t.	t.	PROPN
bptjm-28	391	38	advances	advance	NOUN
bptjm-28	391	39	in	in	ADP
bptjm-28	391	40	gene	gene	NOUN
bptjm-28	391	41	therapy	therapy	NOUN
bptjm-28	391	42	for	for	ADP
bptjm-28	391	43	hemophilia	hemophilia	NOUN
bptjm-28	391	44	:	:	PUNCT
bptjm-28	391	45	basis	basis	NOUN
bptjm-28	391	46	,	,	PUNCT
bptjm-28	391	47	current	current	ADJ
bptjm-28	391	48	status	status	NOUN
bptjm-28	391	49	,	,	PUNCT
bptjm-28	391	50	and	and	CCONJ
bptjm-28	391	51	future	future	ADJ
bptjm-28	391	52	perspectives	perspective	NOUN
bptjm-28	391	53	.	.	PUNCT
bptjm-28	392	1	int	int	NOUN
bptjm-28	392	2	j	j	PROPN
bptjm-28	392	3	hematol	hematol	NOUN
bptjm-28	392	4	111	111	NUM
bptjm-28	392	5	,	,	PUNCT
bptjm-28	392	6	31–41	31–41	NUM
bptjm-28	392	7	(	(	PUNCT
bptjm-28	392	8	2020	2020	NUM
bptjm-28	392	9	)	)	PUNCT
bptjm-28	392	10	.	.	PUNCT
bptjm-28	393	1	https://doi.org/10.1007/s12185-018-2513-4	https://doi.org/10.1007/s12185-018-2513-4	PROPN
bptjm-28	394	1	45	45	NUM
bptjm-28	394	2	.	.	PUNCT
bptjm-28	395	1	james	james	PROPN
bptjm-28	395	2	w.	w.	PROPN
bptjm-28	395	3	larrick	larrick	PROPN
bptjm-28	395	4	,	,	PUNCT
bptjm-28	395	5	m.d	m.d	PROPN
bptjm-28	395	6	.	.	PROPN
bptjm-28	395	7	ph.d	ph.d	PROPN
bptjm-28	395	8	.	.	PROPN
bptjm-28	395	9	,	,	PUNCT
bptjm-28	395	10	interview	interview	NOUN
bptjm-28	395	11	,	,	PUNCT
bptjm-28	395	12	april	april	PROPN
bptjm-28	395	13	27	27	NUM
bptjm-28	395	14	,	,	PUNCT
bptjm-28	395	15	2022	2022	NUM
bptjm-28	395	16	.	.	PUNCT
bptjm-28	396	1	berkeley	berkeley	PROPN
bptjm-28	396	2	pharma	pharma	PROPN
bptjm-28	396	3	tech	tech	PROPN
bptjm-28	396	4	journal	journal	NOUN
bptjm-28	396	5	of	of	ADP
bptjm-28	396	6	medicine	medicine	NOUN
bptjm-28	396	7	|	|	ADV
bptjm-28	396	8	138	138	NUM
bptjm-28	396	9	front_page_repaka	front_page_repaka	PROPN
bptjm-28	396	10	body	body	NOUN