id	sid	tid	token	lemma	pos
bptjm-33	1	1	berkeley	berkeley	PROPN
bptjm-33	1	2	pharma	pharma	PROPN
bptjm-33	1	3	tech	tech	NOUN
bptjm-33	1	4	journal	journal	NOUN
bptjm-33	1	5	of	of	ADP
bptjm-33	1	6	medicine	medicine	NOUN
bptjm-33	1	7	correspondence	correspondence	NOUN
bptjm-33	1	8	:	:	PUNCT
bptjm-33	2	1	ygayoung@umich.edu	ygayoung@umich.edu	PROPN
bptjm-33	2	2	keywords	keyword	NOUN
bptjm-33	2	3	:	:	PUNCT
bptjm-33	2	4	alzheimer	alzheimer	PROPN
bptjm-33	2	5	's	's	PART
bptjm-33	2	6	disease	disease	NOUN
bptjm-33	2	7	(	(	PUNCT
bptjm-33	2	8	ad	ad	NOUN
bptjm-33	2	9	)	)	PUNCT
bptjm-33	2	10	ad	ad	NOUN
bptjm-33	2	11	pathology	pathology	NOUN
bptjm-33	2	12	micrornas	microrna	NOUN
bptjm-33	2	13	(	(	PUNCT
bptjm-33	2	14	mirnas	mirna	NOUN
bptjm-33	2	15	)	)	PUNCT
bptjm-33	2	16	amyloid	amyloid	NOUN
bptjm-33	2	17	cascade	cascade	NOUN
bptjm-33	2	18	hypothesis	hypothesis	NOUN
bptjm-33	2	19	amyloid	amyloid	NOUN
bptjm-33	2	20	beta	beta	NOUN
bptjm-33	2	21	(	(	PUNCT
bptjm-33	2	22	aβ	aβ	NOUN
bptjm-33	2	23	)	)	PUNCT
bptjm-33	2	24	plaques	plaque	NOUN
bptjm-33	2	25	tau	tau	PROPN
bptjm-33	2	26	hypothesis	hypothesis	NOUN
bptjm-33	2	27	neurofibrillary	neurofibrillary	ADJ
bptjm-33	2	28	tangles	tangle	NOUN
bptjm-33	2	29	(	(	PUNCT
bptjm-33	2	30	nft	nft	PROPN
bptjm-33	2	31	)	)	PUNCT
bptjm-33	2	32	submitted	submit	VERB
bptjm-33	2	33	:	:	PUNCT
bptjm-33	2	34	october	october	PROPN
bptjm-33	2	35	5	5	NUM
bptjm-33	2	36	,	,	PUNCT
bptjm-33	2	37	2022	2022	NUM
bptjm-33	2	38	accepted	accept	VERB
bptjm-33	2	39	:	:	PUNCT
bptjm-33	2	40	november	november	PROPN
bptjm-33	2	41	21	21	NUM
bptjm-33	2	42	,	,	PUNCT
bptjm-33	2	43	2022	2022	NUM
bptjm-33	2	44	published	publish	VERB
bptjm-33	2	45	:	:	PUNCT
bptjm-33	2	46	december	december	PROPN
bptjm-33	2	47	28	28	NUM
bptjm-33	2	48	,	,	PUNCT
bptjm-33	2	49	2022	2022	NUM
bptjm-33	2	50	full	full	ADJ
bptjm-33	2	51	open	open	ADJ
bptjm-33	2	52	access	access	NOUN
bptjm-33	2	53	creative	creative	ADJ
bptjm-33	2	54	commons	common	NOUN
bptjm-33	2	55	attribution	attribution	NOUN
bptjm-33	2	56	license	license	VERB
bptjm-33	2	57	4.0	4.0	NUM
bptjm-33	2	58	abstract	abstract	ADJ
bptjm-33	2	59	alzheimer	alzheimer	X
bptjm-33	2	60	’s	’s	PART
bptjm-33	2	61	disease	disease	NOUN
bptjm-33	2	62	(	(	PUNCT
bptjm-33	2	63	ad	ad	NOUN
bptjm-33	2	64	)	)	PUNCT
bptjm-33	2	65	is	be	AUX
bptjm-33	2	66	a	a	DET
bptjm-33	2	67	progressive	progressive	ADJ
bptjm-33	2	68	,	,	PUNCT
bptjm-33	2	69	neurodegenerative	neurodegenerative	ADJ
bptjm-33	2	70	disease	disease	NOUN
bptjm-33	2	71	and	and	CCONJ
bptjm-33	2	72	is	be	AUX
bptjm-33	2	73	the	the	DET
bptjm-33	2	74	most	most	ADV
bptjm-33	2	75	common	common	ADJ
bptjm-33	2	76	cause	cause	NOUN
bptjm-33	2	77	of	of	ADP
bptjm-33	2	78	dementia	dementia	NOUN
bptjm-33	2	79	.	.	PUNCT
bptjm-33	3	1	the	the	DET
bptjm-33	3	2	disease	disease	NOUN
bptjm-33	3	3	pathology	pathology	NOUN
bptjm-33	3	4	of	of	ADP
bptjm-33	3	5	ad	ad	NOUN
bptjm-33	3	6	is	be	AUX
bptjm-33	3	7	marked	mark	VERB
bptjm-33	3	8	by	by	ADP
bptjm-33	3	9	the	the	DET
bptjm-33	3	10	accumulation	accumulation	NOUN
bptjm-33	3	11	of	of	ADP
bptjm-33	3	12	betaamyloid	betaamyloid	PROPN
bptjm-33	3	13	(	(	PUNCT
bptjm-33	3	14	aβ	aβ	NOUN
bptjm-33	3	15	)	)	PUNCT
bptjm-33	3	16	plaques	plaque	NOUN
bptjm-33	3	17	and	and	CCONJ
bptjm-33	3	18	deposition	deposition	NOUN
bptjm-33	3	19	of	of	ADP
bptjm-33	3	20	phosphorylated	phosphorylate	VERB
bptjm-33	3	21	tau	tau	PROPN
bptjm-33	3	22	nfts	nft	NOUN
bptjm-33	3	23	in	in	ADP
bptjm-33	3	24	the	the	DET
bptjm-33	3	25	brain	brain	NOUN
bptjm-33	3	26	.	.	PUNCT
bptjm-33	4	1	currently	currently	ADV
bptjm-33	4	2	,	,	PUNCT
bptjm-33	4	3	the	the	DET
bptjm-33	4	4	therapeutic	therapeutic	ADJ
bptjm-33	4	5	approaches	approach	NOUN
bptjm-33	4	6	to	to	ADP
bptjm-33	4	7	ad	ad	NOUN
bptjm-33	4	8	are	be	AUX
bptjm-33	4	9	solely	solely	ADV
bptjm-33	4	10	palliative	palliative	ADJ
bptjm-33	4	11	in	in	ADP
bptjm-33	4	12	nature	nature	NOUN
bptjm-33	4	13	and	and	CCONJ
bptjm-33	4	14	thus	thus	ADV
bptjm-33	4	15	can	can	AUX
bptjm-33	4	16	do	do	VERB
bptjm-33	4	17	little	little	ADJ
bptjm-33	4	18	to	to	PART
bptjm-33	4	19	stop	stop	VERB
bptjm-33	4	20	or	or	CCONJ
bptjm-33	4	21	reverse	reverse	VERB
bptjm-33	4	22	the	the	DET
bptjm-33	4	23	disease	disease	NOUN
bptjm-33	4	24	pathology	pathology	NOUN
bptjm-33	4	25	once	once	SCONJ
bptjm-33	4	26	it	it	PRON
bptjm-33	4	27	has	have	AUX
bptjm-33	4	28	begun	begin	VERB
bptjm-33	4	29	.	.	PUNCT
bptjm-33	5	1	micrornas	microrna	NOUN
bptjm-33	5	2	(	(	PUNCT
bptjm-33	5	3	mirnas	mirna	NOUN
bptjm-33	5	4	)	)	PUNCT
bptjm-33	5	5	are	be	AUX
bptjm-33	5	6	a	a	DET
bptjm-33	5	7	class	class	NOUN
bptjm-33	5	8	of	of	ADP
bptjm-33	5	9	noncoding	noncode	VERB
bptjm-33	5	10	nucleotides	nucleotide	NOUN
bptjm-33	5	11	that	that	PRON
bptjm-33	5	12	are	be	AUX
bptjm-33	5	13	critically	critically	ADV
bptjm-33	5	14	involved	involve	VERB
bptjm-33	5	15	in	in	ADP
bptjm-33	5	16	the	the	DET
bptjm-33	5	17	regulation	regulation	NOUN
bptjm-33	5	18	of	of	ADP
bptjm-33	5	19	various	various	ADJ
bptjm-33	5	20	posttranscription	posttranscription	NOUN
bptjm-33	5	21	mrna	mrna	NOUN
bptjm-33	5	22	processes	process	NOUN
bptjm-33	5	23	,	,	PUNCT
bptjm-33	5	24	such	such	ADJ
bptjm-33	5	25	as	as	ADP
bptjm-33	5	26	synapse	synapse	NOUN
bptjm-33	5	27	plasticity	plasticity	NOUN
bptjm-33	5	28	and	and	CCONJ
bptjm-33	5	29	neuron	neuron	PROPN
bptjm-33	5	30	differentiation	differentiation	NOUN
bptjm-33	5	31	.	.	PUNCT
bptjm-33	6	1	owing	owe	VERB
bptjm-33	6	2	to	to	ADP
bptjm-33	6	3	the	the	DET
bptjm-33	6	4	multifactorial	multifactorial	ADJ
bptjm-33	6	5	nature	nature	NOUN
bptjm-33	6	6	of	of	ADP
bptjm-33	6	7	ad	ad	NOUN
bptjm-33	6	8	,	,	PUNCT
bptjm-33	6	9	mirnas	mirna	NOUN
bptjm-33	6	10	have	have	AUX
bptjm-33	6	11	garnered	garner	VERB
bptjm-33	6	12	much	much	ADJ
bptjm-33	6	13	attention	attention	NOUN
bptjm-33	6	14	in	in	ADP
bptjm-33	6	15	the	the	DET
bptjm-33	6	16	research	research	NOUN
bptjm-33	6	17	field	field	NOUN
bptjm-33	6	18	due	due	ADP
bptjm-33	6	19	to	to	ADP
bptjm-33	6	20	their	their	PRON
bptjm-33	6	21	concomitant	concomitant	ADJ
bptjm-33	6	22	dysregulation	dysregulation	NOUN
bptjm-33	6	23	and	and	CCONJ
bptjm-33	6	24	appearance	appearance	NOUN
bptjm-33	6	25	in	in	ADP
bptjm-33	6	26	several	several	ADJ
bptjm-33	6	27	ad	ad	NOUN
bptjm-33	6	28	pathophysiological	pathophysiological	ADJ
bptjm-33	6	29	processes	process	NOUN
bptjm-33	6	30	.	.	PUNCT
bptjm-33	7	1	this	this	DET
bptjm-33	7	2	review	review	NOUN
bptjm-33	7	3	paper	paper	NOUN
bptjm-33	7	4	offers	offer	VERB
bptjm-33	7	5	insight	insight	NOUN
bptjm-33	7	6	into	into	ADP
bptjm-33	7	7	the	the	DET
bptjm-33	7	8	potential	potential	ADJ
bptjm-33	7	9	use	use	NOUN
bptjm-33	7	10	of	of	ADP
bptjm-33	7	11	mirnas	mirna	NOUN
bptjm-33	7	12	as	as	ADP
bptjm-33	7	13	a	a	DET
bptjm-33	7	14	therapeutic	therapeutic	ADJ
bptjm-33	7	15	target	target	NOUN
bptjm-33	7	16	and	and	CCONJ
bptjm-33	7	17	diagnostic	diagnostic	ADJ
bptjm-33	7	18	marker	marker	NOUN
bptjm-33	7	19	in	in	ADP
bptjm-33	7	20	ad	ad	NOUN
bptjm-33	7	21	.	.	PUNCT
bptjm-33	8	1	micrornas	microrna	NOUN
bptjm-33	8	2	as	as	ADP
bptjm-33	8	3	a	a	DET
bptjm-33	8	4	diagnostic	diagnostic	ADJ
bptjm-33	8	5	marker	marker	NOUN
bptjm-33	8	6	and	and	CCONJ
bptjm-33	8	7	a	a	DET
bptjm-33	8	8	therapeutic	therapeutic	ADJ
bptjm-33	8	9	target	target	NOUN
bptjm-33	8	10	for	for	ADP
bptjm-33	8	11	alzheimer	alzheimer	PROPN
bptjm-33	8	12	’s	’s	PART
bptjm-33	8	13	disease	disease	NOUN
bptjm-33	8	14	by	by	ADP
bptjm-33	8	15	:	:	PUNCT
bptjm-33	8	16	william	william	PROPN
bptjm-33	8	17	ugorji	ugorji	PROPN
bptjm-33	8	18	,	,	PUNCT
bptjm-33	8	19	gayoung	gayoung	PROPN
bptjm-33	8	20	yang	yang	PROPN
bptjm-33	8	21	and	and	CCONJ
bptjm-33	8	22	prakruti	prakruti	PROPN
bptjm-33	8	23	jajoo	jajoo	PROPN
bptjm-33	8	24	berkeley	berkeley	PROPN
bptjm-33	8	25	pharma	pharma	PROPN
bptjm-33	8	26	tech	tech	PROPN
bptjm-33	8	27	journal	journal	NOUN
bptjm-33	8	28	of	of	ADP
bptjm-33	8	29	medicine	medicine	NOUN
bptjm-33	8	30	|	|	ADV
bptjm-33	8	31	49	49	NUM
bptjm-33	8	32	1	1	NUM
bptjm-33	8	33	.	.	PUNCT
bptjm-33	9	1	introduction	introduction	PROPN
bptjm-33	9	2	alzheimer	alzheimer	PROPN
bptjm-33	9	3	’s	’s	PART
bptjm-33	9	4	disease	disease	NOUN
bptjm-33	9	5	(	(	PUNCT
bptjm-33	9	6	ad	ad	NOUN
bptjm-33	9	7	)	)	PUNCT
bptjm-33	9	8	is	be	AUX
bptjm-33	9	9	the	the	DET
bptjm-33	9	10	leading	lead	VERB
bptjm-33	9	11	cause	cause	NOUN
bptjm-33	9	12	of	of	ADP
bptjm-33	9	13	dementia	dementia	NOUN
bptjm-33	9	14	in	in	ADP
bptjm-33	9	15	the	the	DET
bptjm-33	9	16	world	world	NOUN
bptjm-33	9	17	,	,	PUNCT
bptjm-33	9	18	with	with	ADP
bptjm-33	9	19	a	a	DET
bptjm-33	9	20	disease	disease	NOUN
bptjm-33	9	21	burden	burden	NOUN
bptjm-33	9	22	exceeding	exceed	VERB
bptjm-33	9	23	more	more	ADJ
bptjm-33	9	24	than	than	ADP
bptjm-33	9	25	5.5	5.5	NUM
bptjm-33	9	26	million	million	NUM
bptjm-33	9	27	individuals	individual	NOUN
bptjm-33	9	28	in	in	ADP
bptjm-33	9	29	the	the	DET
bptjm-33	9	30	united	united	PROPN
bptjm-33	9	31	states	states	PROPN
bptjm-33	9	32	and	and	CCONJ
bptjm-33	9	33	up	up	ADP
bptjm-33	9	34	to	to	PART
bptjm-33	9	35	80	80	NUM
bptjm-33	9	36	%	%	NOUN
bptjm-33	9	37	of	of	ADP
bptjm-33	9	38	all	all	DET
bptjm-33	9	39	dementia	dementia	NOUN
bptjm-33	9	40	diagnoses	diagnose	VERB
bptjm-33	9	41	overall1	overall1	PROPN
bptjm-33	9	42	.	.	PUNCT
bptjm-33	10	1	the	the	DET
bptjm-33	10	2	two	two	NUM
bptjm-33	10	3	clinical	clinical	ADJ
bptjm-33	10	4	hallmark	hallmark	ADJ
bptjm-33	10	5	pathologies	pathology	NOUN
bptjm-33	10	6	of	of	ADP
bptjm-33	10	7	the	the	DET
bptjm-33	10	8	disease	disease	NOUN
bptjm-33	10	9	are	be	AUX
bptjm-33	10	10	the	the	DET
bptjm-33	10	11	beta	beta	NOUN
bptjm-33	10	12	-	-	PUNCT
bptjm-33	10	13	amyloid	amyloid	NOUN
bptjm-33	10	14	(	(	PUNCT
bptjm-33	10	15	aβ	aβ	NOUN
bptjm-33	10	16	)	)	PUNCT
bptjm-33	10	17	plaque	plaque	NOUN
bptjm-33	10	18	and	and	CCONJ
bptjm-33	10	19	deposition	deposition	NOUN
bptjm-33	10	20	of	of	ADP
bptjm-33	10	21	neurofibrillary	neurofibrillary	ADJ
bptjm-33	10	22	tangles	tangle	NOUN
bptjm-33	10	23	(	(	PUNCT
bptjm-33	10	24	nfts	nft	NOUN
bptjm-33	10	25	)	)	PUNCT
bptjm-33	10	26	of	of	ADP
bptjm-33	10	27	hyperphosphorylated	hyperphosphorylated	ADJ
bptjm-33	10	28	tau	tau	PROPN
bptjm-33	10	29	hypotheses	hypothesis	NOUN
bptjm-33	10	30	.	.	PUNCT
bptjm-33	11	1	the	the	DET
bptjm-33	11	2	beta	beta	NOUN
bptjm-33	11	3	-	-	PUNCT
bptjm-33	11	4	amyloid	amyloid	NOUN
bptjm-33	11	5	hypothesis	hypothesis	NOUN
bptjm-33	11	6	suggests	suggest	VERB
bptjm-33	11	7	that	that	SCONJ
bptjm-33	11	8	an	an	DET
bptjm-33	11	9	accumulation	accumulation	NOUN
bptjm-33	11	10	of	of	ADP
bptjm-33	11	11	amyloid	amyloid	NOUN
bptjm-33	11	12	plaques	plaque	NOUN
bptjm-33	11	13	in	in	ADP
bptjm-33	11	14	the	the	DET
bptjm-33	11	15	brain	brain	NOUN
bptjm-33	11	16	triggers	trigger	VERB
bptjm-33	11	17	a	a	DET
bptjm-33	11	18	cascade	cascade	NOUN
bptjm-33	11	19	of	of	ADP
bptjm-33	11	20	pathological	pathological	ADJ
bptjm-33	11	21	events	event	NOUN
bptjm-33	11	22	that	that	PRON
bptjm-33	11	23	ultimately	ultimately	ADV
bptjm-33	11	24	lead	lead	VERB
bptjm-33	11	25	to	to	ADP
bptjm-33	11	26	the	the	DET
bptjm-33	11	27	clinical	clinical	ADJ
bptjm-33	11	28	presentation	presentation	NOUN
bptjm-33	11	29	of	of	ADP
bptjm-33	11	30	the	the	DET
bptjm-33	11	31	disease1	disease1	NOUN
bptjm-33	11	32	.	.	PUNCT
bptjm-33	12	1	isoforms	isoform	NOUN
bptjm-33	12	2	of	of	ADP
bptjm-33	12	3	the	the	DET
bptjm-33	12	4	aβ	aβ	NOUN
bptjm-33	12	5	peptide	peptide	NOUN
bptjm-33	12	6	are	be	AUX
bptjm-33	12	7	implicated	implicate	VERB
bptjm-33	12	8	in	in	ADP
bptjm-33	12	9	the	the	DET
bptjm-33	12	10	beta	beta	NOUN
bptjm-33	12	11	-	-	PUNCT
bptjm-33	12	12	amyloid	amyloid	NOUN
bptjm-33	12	13	hypothesis	hypothesis	NOUN
bptjm-33	12	14	,	,	PUNCT
bptjm-33	12	15	and	and	CCONJ
bptjm-33	12	16	aβ38	aβ38	PROPN
bptjm-33	12	17	,	,	PUNCT
bptjm-33	12	18	aβ40	aβ40	PROPN
bptjm-33	12	19	,	,	PUNCT
bptjm-33	12	20	and	and	CCONJ
bptjm-33	12	21	aβ42	aβ42	PROPN
bptjm-33	12	22	exhibit	exhibit	VERB
bptjm-33	12	23	the	the	DET
bptjm-33	12	24	greatest	great	ADJ
bptjm-33	12	25	tendency	tendency	NOUN
bptjm-33	12	26	to	to	PART
bptjm-33	12	27	cluster	cluster	VERB
bptjm-33	12	28	and	and	CCONJ
bptjm-33	12	29	produce	produce	VERB
bptjm-33	12	30	the	the	DET
bptjm-33	12	31	neuronal	neuronal	ADJ
bptjm-33	12	32	oligomers	oligomer	NOUN
bptjm-33	12	33	that	that	PRON
bptjm-33	12	34	trigger	trigger	VERB
bptjm-33	12	35	the	the	DET
bptjm-33	12	36	amyloid	amyloid	NOUN
bptjm-33	12	37	cascade1	cascade1	PROPN
bptjm-33	12	38	.	.	PUNCT
bptjm-33	13	1	within	within	ADP
bptjm-33	13	2	this	this	DET
bptjm-33	13	3	cascade	cascade	NOUN
bptjm-33	13	4	,	,	PUNCT
bptjm-33	13	5	various	various	ADJ
bptjm-33	13	6	biological	biological	ADJ
bptjm-33	13	7	stressors	stressor	NOUN
bptjm-33	13	8	,	,	PUNCT
bptjm-33	13	9	such	such	ADJ
bptjm-33	13	10	as	as	ADP
bptjm-33	13	11	localized	localized	ADJ
bptjm-33	13	12	inflammation	inflammation	NOUN
bptjm-33	13	13	,	,	PUNCT
bptjm-33	13	14	glutamate	glutamate	ADJ
bptjm-33	13	15	production	production	NOUN
bptjm-33	13	16	,	,	PUNCT
bptjm-33	13	17	and	and	CCONJ
bptjm-33	13	18	oxidation	oxidation	NOUN
bptjm-33	13	19	,	,	PUNCT
bptjm-33	13	20	are	be	AUX
bptjm-33	13	21	involved	involve	VERB
bptjm-33	13	22	.	.	PUNCT
bptjm-33	14	1	conversely	conversely	ADV
bptjm-33	14	2	,	,	PUNCT
bptjm-33	14	3	the	the	DET
bptjm-33	14	4	tau	tau	PROPN
bptjm-33	14	5	hypothesis	hypothesis	NOUN
bptjm-33	14	6	entails	entail	VERB
bptjm-33	14	7	the	the	DET
bptjm-33	14	8	process	process	NOUN
bptjm-33	14	9	of	of	ADP
bptjm-33	14	10	hyperphosphorylated	hyperphosphorylated	ADJ
bptjm-33	14	11	tau	tau	PROPN
bptjm-33	14	12	decoupling	decouple	VERB
bptjm-33	14	13	from	from	ADP
bptjm-33	14	14	their	their	PRON
bptjm-33	14	15	normal	normal	ADJ
bptjm-33	14	16	microtubule	microtubule	NOUN
bptjm-33	14	17	function	function	NOUN
bptjm-33	14	18	to	to	PART
bptjm-33	14	19	form	form	VERB
bptjm-33	14	20	nfts	nft	NOUN
bptjm-33	14	21	that	that	PRON
bptjm-33	14	22	disrupt	disrupt	VERB
bptjm-33	14	23	normal	normal	ADJ
bptjm-33	14	24	neuronal	neuronal	ADJ
bptjm-33	14	25	function	function	NOUN
bptjm-33	14	26	and	and	CCONJ
bptjm-33	14	27	transport	transport	NOUN
bptjm-33	14	28	.	.	PUNCT
bptjm-33	15	1	while	while	SCONJ
bptjm-33	15	2	the	the	DET
bptjm-33	15	3	beta	beta	NOUN
bptjm-33	15	4	-	-	PUNCT
bptjm-33	15	5	amyloid	amyloid	NOUN
bptjm-33	15	6	and	and	CCONJ
bptjm-33	15	7	tau	tau	PROPN
bptjm-33	15	8	hypothesis	hypothesis	NOUN
bptjm-33	15	9	were	be	AUX
bptjm-33	15	10	initially	initially	ADV
bptjm-33	15	11	regarded	regard	VERB
bptjm-33	15	12	as	as	ADP
bptjm-33	15	13	two	two	NUM
bptjm-33	15	14	distinct	distinct	ADJ
bptjm-33	15	15	pathophysiological	pathophysiological	ADJ
bptjm-33	15	16	pathways	pathway	NOUN
bptjm-33	15	17	,	,	PUNCT
bptjm-33	15	18	recent	recent	ADJ
bptjm-33	15	19	evidence	evidence	NOUN
bptjm-33	15	20	has	have	AUX
bptjm-33	15	21	given	give	VERB
bptjm-33	15	22	credence	credence	NOUN
bptjm-33	15	23	to	to	ADP
bptjm-33	15	24	the	the	DET
bptjm-33	15	25	notion	notion	NOUN
bptjm-33	15	26	that	that	SCONJ
bptjm-33	15	27	both	both	DET
bptjm-33	15	28	pathways	pathway	NOUN
bptjm-33	15	29	act	act	VERB
bptjm-33	15	30	interdependently	interdependently	ADV
bptjm-33	15	31	,	,	PUNCT
bptjm-33	15	32	resulting	result	VERB
bptjm-33	15	33	in	in	ADP
bptjm-33	15	34	the	the	DET
bptjm-33	15	35	clinical	clinical	ADJ
bptjm-33	15	36	presentation	presentation	NOUN
bptjm-33	15	37	of	of	ADP
bptjm-33	15	38	ad1	ad1	PROPN
bptjm-33	15	39	.	.	PUNCT
bptjm-33	15	40	symptoms	symptom	NOUN
bptjm-33	15	41	of	of	ADP
bptjm-33	15	42	cognitive	cognitive	ADJ
bptjm-33	15	43	impairment	impairment	NOUN
bptjm-33	15	44	and	and	CCONJ
bptjm-33	15	45	memory	memory	NOUN
bptjm-33	15	46	loss	loss	NOUN
bptjm-33	15	47	are	be	AUX
bptjm-33	15	48	the	the	DET
bptjm-33	15	49	main	main	ADJ
bptjm-33	15	50	assessment	assessment	NOUN
bptjm-33	15	51	criteria	criterion	NOUN
bptjm-33	15	52	for	for	ADP
bptjm-33	15	53	ad	ad	NOUN
bptjm-33	15	54	patients	patient	NOUN
bptjm-33	15	55	,	,	PUNCT
bptjm-33	15	56	and	and	CCONJ
bptjm-33	15	57	differential	differential	ADJ
bptjm-33	15	58	diagnosis	diagnosis	NOUN
bptjm-33	15	59	can	can	AUX
bptjm-33	15	60	be	be	AUX
bptjm-33	15	61	made	make	VERB
bptjm-33	15	62	through	through	ADP
bptjm-33	15	63	cerebrospinal	cerebrospinal	ADJ
bptjm-33	15	64	fluid	fluid	NOUN
bptjm-33	15	65	(	(	PUNCT
bptjm-33	15	66	csf	csf	NOUN
bptjm-33	15	67	)	)	PUNCT
bptjm-33	15	68	and	and	CCONJ
bptjm-33	15	69	positron	positron	NOUN
bptjm-33	15	70	emission	emission	NOUN
bptjm-33	15	71	tomography	tomography	NOUN
bptjm-33	15	72	(	(	PUNCT
bptjm-33	15	73	pet	pet	NOUN
bptjm-33	15	74	)	)	PUNCT
bptjm-33	15	75	analysis1	analysis1	PROPN
bptjm-33	15	76	.	.	PUNCT
bptjm-33	16	1	these	these	DET
bptjm-33	16	2	methods	method	NOUN
bptjm-33	16	3	,	,	PUNCT
bptjm-33	16	4	however	however	ADV
bptjm-33	16	5	,	,	PUNCT
bptjm-33	16	6	suffer	suffer	VERB
bptjm-33	16	7	from	from	ADP
bptjm-33	16	8	issues	issue	NOUN
bptjm-33	16	9	such	such	ADJ
bptjm-33	16	10	as	as	ADP
bptjm-33	16	11	the	the	DET
bptjm-33	16	12	high	high	ADJ
bptjm-33	16	13	cost	cost	NOUN
bptjm-33	16	14	of	of	ADP
bptjm-33	16	15	application	application	NOUN
bptjm-33	16	16	,	,	PUNCT
bptjm-33	16	17	invasiveness	invasiveness	ADJ
bptjm-33	16	18	,	,	PUNCT
bptjm-33	16	19	and	and	CCONJ
bptjm-33	16	20	low	low	ADJ
bptjm-33	16	21	specificity	specificity	NOUN
bptjm-33	16	22	that	that	PRON
bptjm-33	16	23	combine	combine	VERB
bptjm-33	16	24	to	to	PART
bptjm-33	16	25	limit	limit	VERB
bptjm-33	16	26	their	their	PRON
bptjm-33	16	27	accessibility	accessibility	NOUN
bptjm-33	16	28	and	and	CCONJ
bptjm-33	16	29	usage	usage	NOUN
bptjm-33	16	30	in	in	ADP
bptjm-33	16	31	routine	routine	ADJ
bptjm-33	16	32	clinical	clinical	ADJ
bptjm-33	16	33	scenarios2	scenarios2	NOUN
bptjm-33	16	34	.	.	PUNCT
bptjm-33	17	1	as	as	ADP
bptjm-33	17	2	such	such	ADJ
bptjm-33	17	3	,	,	PUNCT
bptjm-33	17	4	a	a	DET
bptjm-33	17	5	definitive	definitive	ADJ
bptjm-33	17	6	diagnosis	diagnosis	NOUN
bptjm-33	17	7	of	of	ADP
bptjm-33	17	8	ad	ad	NOUN
bptjm-33	17	9	can	can	AUX
bptjm-33	17	10	only	only	ADV
bptjm-33	17	11	be	be	AUX
bptjm-33	17	12	made	make	VERB
bptjm-33	17	13	through	through	ADP
bptjm-33	17	14	post	post	ADJ
bptjm-33	17	15	-	-	ADJ
bptjm-33	17	16	mortem	mortem	ADJ
bptjm-33	17	17	tissue	tissue	NOUN
bptjm-33	17	18	analysis	analysis	NOUN
bptjm-33	17	19	of	of	ADP
bptjm-33	17	20	suspected	suspect	VERB
bptjm-33	17	21	ad	ad	NOUN
bptjm-33	17	22	patients	patient	NOUN
bptjm-33	17	23	.	.	PUNCT
bptjm-33	18	1	the	the	DET
bptjm-33	18	2	current	current	ADJ
bptjm-33	18	3	treatment	treatment	NOUN
bptjm-33	18	4	landscape	landscape	NOUN
bptjm-33	18	5	for	for	ADP
bptjm-33	18	6	ad	ad	NOUN
bptjm-33	18	7	primarily	primarily	ADV
bptjm-33	18	8	involves	involve	VERB
bptjm-33	18	9	palliative	palliative	ADJ
bptjm-33	18	10	therapeutic	therapeutic	ADJ
bptjm-33	18	11	approaches	approach	NOUN
bptjm-33	18	12	,	,	PUNCT
bptjm-33	18	13	such	such	ADJ
bptjm-33	18	14	as	as	ADP
bptjm-33	18	15	cholinesterase	cholinesterase	NOUN
bptjm-33	18	16	inhibitors	inhibitor	NOUN
bptjm-33	18	17	and	and	CCONJ
bptjm-33	18	18	n	n	CCONJ
bptjm-33	18	19	-	-	PUNCT
bptjm-33	18	20	methyl	methyl	NOUN
bptjm-33	18	21	daspartate	daspartate	NOUN
bptjm-33	18	22	(	(	PUNCT
bptjm-33	18	23	nmda	nmda	ADJ
bptjm-33	18	24	)	)	PUNCT
bptjm-33	18	25	antagonists	antagonist	NOUN
bptjm-33	18	26	like	like	ADP
bptjm-33	18	27	memantine	memantine	NOUN
bptjm-33	18	28	.	.	PUNCT
bptjm-33	19	1	cholinesterase	cholinesterase	NOUN
bptjm-33	19	2	inhibitors	inhibitor	NOUN
bptjm-33	19	3	include	include	VERB
bptjm-33	19	4	drug	drug	NOUN
bptjm-33	19	5	classes	class	NOUN
bptjm-33	19	6	like	like	ADP
bptjm-33	19	7	donepezil	donepezil	NOUN
bptjm-33	19	8	and	and	CCONJ
bptjm-33	19	9	galantamine	galantamine	VERB
bptjm-33	19	10	and	and	CCONJ
bptjm-33	19	11	work	work	NOUN
bptjm-33	19	12	by	by	ADP
bptjm-33	19	13	stopping	stop	VERB
bptjm-33	19	14	the	the	DET
bptjm-33	19	15	degradation	degradation	NOUN
bptjm-33	19	16	of	of	ADP
bptjm-33	19	17	acetylcholine	acetylcholine	ADJ
bptjm-33	19	18	molecules	molecule	NOUN
bptjm-33	19	19	in	in	ADP
bptjm-33	19	20	the	the	DET
bptjm-33	19	21	brain3	brain3	NOUN
bptjm-33	19	22	.	.	PUNCT
bptjm-33	20	1	cholinesterase	cholinesterase	NOUN
bptjm-33	20	2	inhibitors	inhibitor	NOUN
bptjm-33	20	3	are	be	AUX
bptjm-33	20	4	typically	typically	ADV
bptjm-33	20	5	prescribed	prescribe	VERB
bptjm-33	20	6	for	for	ADP
bptjm-33	20	7	ad	ad	NOUN
bptjm-33	20	8	patients	patient	NOUN
bptjm-33	20	9	in	in	ADP
bptjm-33	20	10	the	the	DET
bptjm-33	20	11	mild	mild	ADJ
bptjm-33	20	12	,	,	PUNCT
bptjm-33	20	13	moderate	moderate	ADJ
bptjm-33	20	14	,	,	PUNCT
bptjm-33	20	15	or	or	CCONJ
bptjm-33	20	16	berkeley	berkeley	PROPN
bptjm-33	20	17	pharma	pharma	PROPN
bptjm-33	20	18	tech	tech	NOUN
bptjm-33	20	19	journal	journal	NOUN
bptjm-33	20	20	of	of	ADP
bptjm-33	20	21	medicine	medicine	NOUN
bptjm-33	20	22	|	|	ADV
bptjm-33	20	23	50	50	NUM
bptjm-33	20	24	severe	severe	ADJ
bptjm-33	20	25	dementia	dementia	NOUN
bptjm-33	20	26	stages	stage	NOUN
bptjm-33	20	27	based	base	VERB
bptjm-33	20	28	on	on	ADP
bptjm-33	20	29	the	the	DET
bptjm-33	20	30	mini	mini	ADJ
bptjm-33	20	31	-	-	ADJ
bptjm-33	20	32	mental	mental	ADJ
bptjm-33	20	33	state	state	NOUN
bptjm-33	20	34	examination	examination	NOUN
bptjm-33	20	35	score	score	NOUN
bptjm-33	20	36	(	(	PUNCT
bptjm-33	20	37	mmse)4	mmse)4	X
bptjm-33	20	38	.	.	PUNCT
bptjm-33	21	1	nmda	nmda	ADJ
bptjm-33	21	2	antagonists	antagonist	NOUN
bptjm-33	21	3	function	function	VERB
bptjm-33	21	4	by	by	ADP
bptjm-33	21	5	regulating	regulate	VERB
bptjm-33	21	6	glutamate	glutamate	ADJ
bptjm-33	21	7	action	action	NOUN
bptjm-33	21	8	in	in	ADP
bptjm-33	21	9	the	the	DET
bptjm-33	21	10	brain3	brain3	NOUN
bptjm-33	21	11	.	.	PUNCT
bptjm-33	22	1	while	while	SCONJ
bptjm-33	22	2	the	the	DET
bptjm-33	22	3	current	current	ADJ
bptjm-33	22	4	pharmacological	pharmacological	ADJ
bptjm-33	22	5	approaches	approach	NOUN
bptjm-33	22	6	for	for	ADP
bptjm-33	22	7	ad	ad	NOUN
bptjm-33	22	8	can	can	AUX
bptjm-33	22	9	enhance	enhance	VERB
bptjm-33	22	10	patient	patient	ADJ
bptjm-33	22	11	quality	quality	NOUN
bptjm-33	22	12	of	of	ADP
bptjm-33	22	13	life	life	NOUN
bptjm-33	22	14	,	,	PUNCT
bptjm-33	22	15	they	they	PRON
bptjm-33	22	16	are	be	AUX
bptjm-33	22	17	unable	unable	ADJ
bptjm-33	22	18	to	to	PART
bptjm-33	22	19	alter	alter	VERB
bptjm-33	22	20	disease	disease	NOUN
bptjm-33	22	21	progression	progression	NOUN
bptjm-33	22	22	or	or	CCONJ
bptjm-33	22	23	overall	overall	ADJ
bptjm-33	22	24	life	life	NOUN
bptjm-33	22	25	expectancy	expectancy	NOUN
bptjm-33	22	26	for	for	ADP
bptjm-33	22	27	individuals	individual	NOUN
bptjm-33	22	28	with	with	ADP
bptjm-33	22	29	ad	ad	NOUN
bptjm-33	22	30	.	.	PUNCT
bptjm-33	23	1	as	as	ADP
bptjm-33	23	2	such	such	ADJ
bptjm-33	23	3	,	,	PUNCT
bptjm-33	23	4	there	there	PRON
bptjm-33	23	5	exists	exist	VERB
bptjm-33	23	6	a	a	DET
bptjm-33	23	7	great	great	ADJ
bptjm-33	23	8	need	need	NOUN
bptjm-33	23	9	to	to	PART
bptjm-33	23	10	develop	develop	VERB
bptjm-33	23	11	a	a	DET
bptjm-33	23	12	non	non	ADJ
bptjm-33	23	13	-	-	ADJ
bptjm-33	23	14	invasive	invasive	ADJ
bptjm-33	23	15	,	,	PUNCT
bptjm-33	23	16	cost	cost	NOUN
bptjm-33	23	17	-	-	PUNCT
bptjm-33	23	18	effective	effective	ADJ
bptjm-33	23	19	approach	approach	NOUN
bptjm-33	23	20	to	to	PART
bptjm-33	23	21	provide	provide	VERB
bptjm-33	23	22	robust	robust	ADJ
bptjm-33	23	23	early	early	ADJ
bptjm-33	23	24	diagnosis	diagnosis	NOUN
bptjm-33	23	25	and	and	CCONJ
bptjm-33	23	26	treatment	treatment	NOUN
bptjm-33	23	27	options	option	NOUN
bptjm-33	23	28	for	for	ADP
bptjm-33	23	29	this	this	DET
bptjm-33	23	30	condition	condition	NOUN
bptjm-33	23	31	in	in	ADP
bptjm-33	23	32	the	the	DET
bptjm-33	23	33	medical	medical	ADJ
bptjm-33	23	34	community	community	NOUN
bptjm-33	23	35	.	.	PUNCT
bptjm-33	24	1	micrornas	microrna	NOUN
bptjm-33	24	2	(	(	PUNCT
bptjm-33	24	3	mirnas	mirna	NOUN
bptjm-33	24	4	)	)	PUNCT
bptjm-33	24	5	are	be	AUX
bptjm-33	24	6	a	a	DET
bptjm-33	24	7	class	class	NOUN
bptjm-33	24	8	of	of	ADP
bptjm-33	24	9	small	small	ADJ
bptjm-33	24	10	,	,	PUNCT
bptjm-33	24	11	non	non	ADJ
bptjm-33	24	12	-	-	ADJ
bptjm-33	24	13	coding	code	VERB
bptjm-33	24	14	rna	rna	NOUN
bptjm-33	24	15	molecules	molecule	NOUN
bptjm-33	24	16	that	that	PRON
bptjm-33	24	17	have	have	VERB
bptjm-33	24	18	the	the	DET
bptjm-33	24	19	potential	potential	NOUN
bptjm-33	24	20	to	to	PART
bptjm-33	24	21	act	act	VERB
bptjm-33	24	22	as	as	ADP
bptjm-33	24	23	therapeutic	therapeutic	ADJ
bptjm-33	24	24	agents	agent	NOUN
bptjm-33	24	25	and	and	CCONJ
bptjm-33	24	26	biomarkers	biomarker	NOUN
bptjm-33	24	27	in	in	ADP
bptjm-33	24	28	ad	ad	NOUN
bptjm-33	24	29	.	.	PUNCT
bptjm-33	25	1	ranging	range	VERB
bptjm-33	25	2	approximately	approximately	ADV
bptjm-33	25	3	22	22	NUM
bptjm-33	25	4	nucleotides	nucleotide	NOUN
bptjm-33	25	5	in	in	ADP
bptjm-33	25	6	length	length	NOUN
bptjm-33	25	7	,	,	PUNCT
bptjm-33	25	8	mirnas	mirna	NOUN
bptjm-33	25	9	work	work	VERB
bptjm-33	25	10	on	on	ADP
bptjm-33	25	11	the	the	DET
bptjm-33	25	12	posttranscriptional	posttranscriptional	ADJ
bptjm-33	25	13	level	level	NOUN
bptjm-33	25	14	of	of	ADP
bptjm-33	25	15	mrnas	mrna	NOUN
bptjm-33	25	16	and	and	CCONJ
bptjm-33	25	17	are	be	AUX
bptjm-33	25	18	involved	involve	VERB
bptjm-33	25	19	in	in	ADP
bptjm-33	25	20	the	the	DET
bptjm-33	25	21	regulation	regulation	NOUN
bptjm-33	25	22	of	of	ADP
bptjm-33	25	23	nearly	nearly	ADV
bptjm-33	25	24	every	every	PRON
bptjm-33	25	25	cell	cell	NOUN
bptjm-33	25	26	and	and	CCONJ
bptjm-33	25	27	protein	protein	NOUN
bptjm-33	25	28	-	-	PUNCT
bptjm-33	25	29	coding	code	VERB
bptjm-33	25	30	process	process	NOUN
bptjm-33	25	31	in	in	ADP
bptjm-33	25	32	the	the	DET
bptjm-33	25	33	body5	body5	NOUN
bptjm-33	25	34	.	.	PUNCT
bptjm-33	26	1	a	a	DET
bptjm-33	26	2	few	few	ADJ
bptjm-33	26	3	of	of	ADP
bptjm-33	26	4	the	the	DET
bptjm-33	26	5	regulatory	regulatory	ADJ
bptjm-33	26	6	facets	facet	NOUN
bptjm-33	26	7	that	that	PRON
bptjm-33	26	8	mirnas	mirna	NOUN
bptjm-33	26	9	act	act	VERB
bptjm-33	26	10	on	on	ADP
bptjm-33	26	11	include	include	VERB
bptjm-33	26	12	cellular	cellular	ADJ
bptjm-33	26	13	differentiation	differentiation	NOUN
bptjm-33	26	14	,	,	PUNCT
bptjm-33	26	15	proliferation	proliferation	NOUN
bptjm-33	26	16	,	,	PUNCT
bptjm-33	26	17	as	as	ADV
bptjm-33	26	18	well	well	ADV
bptjm-33	26	19	as	as	ADP
bptjm-33	26	20	programmed	program	VERB
bptjm-33	26	21	cell	cell	NOUN
bptjm-33	26	22	-	-	PUNCT
bptjm-33	26	23	death	death	NOUN
bptjm-33	26	24	mechanisms	mechanism	NOUN
bptjm-33	26	25	like	like	ADP
bptjm-33	26	26	apoptosis6	apoptosis6	NOUN
bptjm-33	26	27	.	.	PUNCT
bptjm-33	27	1	a	a	DET
bptjm-33	27	2	single	single	ADJ
bptjm-33	27	3	mirna	mirna	NOUN
bptjm-33	27	4	can	can	AUX
bptjm-33	27	5	alter	alter	VERB
bptjm-33	27	6	up	up	ADP
bptjm-33	27	7	to	to	ADP
bptjm-33	27	8	200	200	NUM
bptjm-33	27	9	mrnas	mrna	NOUN
bptjm-33	27	10	and	and	CCONJ
bptjm-33	27	11	multiple	multiple	ADJ
bptjm-33	27	12	genes	gene	NOUN
bptjm-33	27	13	,	,	PUNCT
bptjm-33	27	14	thus	thus	ADV
bptjm-33	27	15	making	make	VERB
bptjm-33	27	16	them	they	PRON
bptjm-33	27	17	increasingly	increasingly	ADV
bptjm-33	27	18	valuable	valuable	ADJ
bptjm-33	27	19	targets	target	NOUN
bptjm-33	27	20	for	for	ADP
bptjm-33	27	21	research	research	NOUN
bptjm-33	27	22	into	into	ADP
bptjm-33	27	23	how	how	SCONJ
bptjm-33	27	24	changes	change	NOUN
bptjm-33	27	25	in	in	ADP
bptjm-33	27	26	their	their	PRON
bptjm-33	27	27	expression	expression	NOUN
bptjm-33	27	28	levels	level	NOUN
bptjm-33	27	29	contribute	contribute	VERB
bptjm-33	27	30	to	to	ADP
bptjm-33	27	31	disease	disease	NOUN
bptjm-33	27	32	states	state	NOUN
bptjm-33	27	33	such	such	ADJ
bptjm-33	27	34	as	as	ADP
bptjm-33	27	35	ad	ad	NOUN
bptjm-33	27	36	or	or	CCONJ
bptjm-33	27	37	cancer5	cancer5	PROPN
bptjm-33	27	38	.	.	PUNCT
bptjm-33	28	1	mirnas	mirna	NOUN
bptjm-33	28	2	specifically	specifically	ADV
bptjm-33	28	3	function	function	VERB
bptjm-33	28	4	by	by	ADP
bptjm-33	28	5	attaching	attach	VERB
bptjm-33	28	6	and	and	CCONJ
bptjm-33	28	7	binding	bind	VERB
bptjm-33	28	8	to	to	ADP
bptjm-33	28	9	the	the	DET
bptjm-33	28	10	3	3	NUM
bptjm-33	28	11	’	'	PUNCT
bptjm-33	28	12	untranslated	untranslated	ADJ
bptjm-33	28	13	region	region	NOUN
bptjm-33	28	14	(	(	PUNCT
bptjm-33	28	15	utr	utr	NOUN
bptjm-33	28	16	)	)	PUNCT
bptjm-33	28	17	of	of	ADP
bptjm-33	28	18	their	their	PRON
bptjm-33	28	19	associated	associated	ADJ
bptjm-33	28	20	mrnas	mrna	NOUN
bptjm-33	28	21	,	,	PUNCT
bptjm-33	28	22	in	in	ADP
bptjm-33	28	23	which	which	PRON
bptjm-33	28	24	the	the	DET
bptjm-33	28	25	complementarity	complementarity	NOUN
bptjm-33	28	26	between	between	ADP
bptjm-33	28	27	the	the	DET
bptjm-33	28	28	mirna	mirna	NOUN
bptjm-33	28	29	and	and	CCONJ
bptjm-33	28	30	its	its	PRON
bptjm-33	28	31	target	target	NOUN
bptjm-33	28	32	eventually	eventually	ADV
bptjm-33	28	33	results	result	VERB
bptjm-33	28	34	in	in	ADP
bptjm-33	28	35	the	the	DET
bptjm-33	28	36	degradation	degradation	NOUN
bptjm-33	28	37	of	of	ADP
bptjm-33	28	38	the	the	DET
bptjm-33	28	39	mrna	mrna	PROPN
bptjm-33	28	40	targets7	targets7	PROPN
bptjm-33	28	41	.	.	PUNCT
bptjm-33	29	1	current	current	ADJ
bptjm-33	29	2	research	research	NOUN
bptjm-33	29	3	shows	show	VERB
bptjm-33	29	4	that	that	SCONJ
bptjm-33	29	5	approximately	approximately	ADV
bptjm-33	29	6	70	70	NUM
bptjm-33	29	7	%	%	NOUN
bptjm-33	29	8	of	of	ADP
bptjm-33	29	9	identified	identify	VERB
bptjm-33	29	10	mirnas	mirna	NOUN
bptjm-33	29	11	have	have	VERB
bptjm-33	29	12	expression	expression	NOUN
bptjm-33	29	13	patterns	pattern	NOUN
bptjm-33	29	14	in	in	ADP
bptjm-33	29	15	the	the	DET
bptjm-33	29	16	brain	brain	NOUN
bptjm-33	29	17	,	,	PUNCT
bptjm-33	29	18	which	which	PRON
bptjm-33	29	19	further	far	ADV
bptjm-33	29	20	highlights	highlight	VERB
bptjm-33	29	21	the	the	DET
bptjm-33	29	22	dynamic	dynamic	ADJ
bptjm-33	29	23	potential	potential	NOUN
bptjm-33	29	24	of	of	ADP
bptjm-33	29	25	mirna	mirna	NOUN
bptjm-33	29	26	processes	process	NOUN
bptjm-33	29	27	in	in	ADP
bptjm-33	29	28	healthy	healthy	ADJ
bptjm-33	29	29	brain	brain	NOUN
bptjm-33	29	30	function	function	NOUN
bptjm-33	29	31	and	and	CCONJ
bptjm-33	29	32	diseased	disease	VERB
bptjm-33	29	33	states7	states7	NOUN
bptjm-33	29	34	.	.	PUNCT
bptjm-33	30	1	within	within	ADP
bptjm-33	30	2	the	the	DET
bptjm-33	30	3	brain	brain	NOUN
bptjm-33	30	4	and	and	CCONJ
bptjm-33	30	5	nervous	nervous	ADJ
bptjm-33	30	6	system	system	NOUN
bptjm-33	30	7	environment	environment	NOUN
bptjm-33	30	8	,	,	PUNCT
bptjm-33	30	9	mirnas	mirna	NOUN
bptjm-33	30	10	are	be	AUX
bptjm-33	30	11	particularly	particularly	ADV
bptjm-33	30	12	involved	involve	VERB
bptjm-33	30	13	in	in	ADP
bptjm-33	30	14	regulating	regulate	VERB
bptjm-33	30	15	synapse	synapse	NOUN
bptjm-33	30	16	plasticity	plasticity	NOUN
bptjm-33	30	17	,	,	PUNCT
bptjm-33	30	18	dendritic	dendritic	ADJ
bptjm-33	30	19	spine	spine	ADJ
bptjm-33	30	20	morphology	morphology	NOUN
bptjm-33	30	21	,	,	PUNCT
bptjm-33	30	22	and	and	CCONJ
bptjm-33	30	23	neurite	neurite	VERB
bptjm-33	30	24	outgrowth	outgrowth	NOUN
bptjm-33	30	25	,	,	PUNCT
bptjm-33	30	26	thus	thus	ADV
bptjm-33	30	27	contributing	contribute	VERB
bptjm-33	30	28	to	to	ADP
bptjm-33	30	29	the	the	DET
bptjm-33	30	30	modulation	modulation	NOUN
bptjm-33	30	31	of	of	ADP
bptjm-33	30	32	the	the	DET
bptjm-33	30	33	cognitive	cognitive	ADJ
bptjm-33	30	34	and	and	CCONJ
bptjm-33	30	35	memory	memory	NOUN
bptjm-33	30	36	functions	function	NOUN
bptjm-33	30	37	typically	typically	ADV
bptjm-33	30	38	lost	lose	VERB
bptjm-33	30	39	in	in	ADP
bptjm-33	30	40	ad	ad	NOUN
bptjm-33	30	41	pathology	pathology	NOUN
bptjm-33	30	42	through	through	ADP
bptjm-33	30	43	acting	act	VERB
bptjm-33	30	44	upon	upon	SCONJ
bptjm-33	30	45	protein	protein	NOUN
bptjm-33	30	46	synthesis	synthesis	NOUN
bptjm-33	30	47	in	in	ADP
bptjm-33	30	48	synapses8	synapses8	NOUN
bptjm-33	30	49	.	.	PUNCT
bptjm-33	31	1	mirnas	mirna	NOUN
bptjm-33	31	2	are	be	AUX
bptjm-33	31	3	predominantly	predominantly	ADV
bptjm-33	31	4	found	find	VERB
bptjm-33	31	5	in	in	ADP
bptjm-33	31	6	circulatory	circulatory	ADJ
bptjm-33	31	7	biofluids	biofluid	NOUN
bptjm-33	31	8	,	,	PUNCT
bptjm-33	31	9	such	such	ADJ
bptjm-33	31	10	as	as	ADP
bptjm-33	31	11	blood	blood	NOUN
bptjm-33	31	12	serum	serum	NOUN
bptjm-33	31	13	and	and	CCONJ
bptjm-33	31	14	plasma9	plasma9	NOUN
bptjm-33	31	15	.	.	PUNCT
bptjm-33	32	1	due	due	ADP
bptjm-33	32	2	to	to	ADP
bptjm-33	32	3	its	its	PRON
bptjm-33	32	4	proliferation	proliferation	NOUN
bptjm-33	32	5	in	in	ADP
bptjm-33	32	6	the	the	DET
bptjm-33	32	7	blood	blood	NOUN
bptjm-33	32	8	serum	serum	NOUN
bptjm-33	32	9	,	,	PUNCT
bptjm-33	32	10	mirna	mirna	PROPN
bptjm-33	32	11	has	have	VERB
bptjm-33	32	12	wide	wide	ADJ
bptjm-33	32	13	potential	potential	NOUN
bptjm-33	32	14	to	to	PART
bptjm-33	32	15	be	be	AUX
bptjm-33	32	16	a	a	DET
bptjm-33	32	17	cost	cost	NOUN
bptjm-33	32	18	-	-	PUNCT
bptjm-33	32	19	effective	effective	ADJ
bptjm-33	32	20	and	and	CCONJ
bptjm-33	32	21	less	less	ADV
bptjm-33	32	22	invasive	invasive	ADJ
bptjm-33	32	23	diagnostic	diagnostic	ADJ
bptjm-33	32	24	approach	approach	NOUN
bptjm-33	32	25	for	for	ADP
bptjm-33	32	26	ad	ad	NOUN
bptjm-33	32	27	.	.	PUNCT
bptjm-33	33	1	in	in	ADP
bptjm-33	33	2	this	this	DET
bptjm-33	33	3	review	review	NOUN
bptjm-33	33	4	,	,	PUNCT
bptjm-33	33	5	we	we	PRON
bptjm-33	33	6	focus	focus	VERB
bptjm-33	33	7	on	on	ADP
bptjm-33	33	8	exploring	explore	VERB
bptjm-33	33	9	the	the	DET
bptjm-33	33	10	most	most	ADV
bptjm-33	33	11	recent	recent	ADJ
bptjm-33	33	12	advances	advance	NOUN
bptjm-33	33	13	in	in	ADP
bptjm-33	33	14	the	the	DET
bptjm-33	33	15	berkeley	berkeley	PROPN
bptjm-33	33	16	pharma	pharma	PROPN
bptjm-33	33	17	tech	tech	NOUN
bptjm-33	33	18	journal	journal	NOUN
bptjm-33	33	19	of	of	ADP
bptjm-33	33	20	medicine	medicine	NOUN
bptjm-33	33	21	|	|	ADV
bptjm-33	33	22	51	51	NUM
bptjm-33	33	23	research	research	NOUN
bptjm-33	33	24	and	and	CCONJ
bptjm-33	33	25	development	development	NOUN
bptjm-33	33	26	of	of	ADP
bptjm-33	33	27	mirnas	mirna	NOUN
bptjm-33	33	28	involvement	involvement	NOUN
bptjm-33	33	29	in	in	ADP
bptjm-33	33	30	ad	ad	NOUN
bptjm-33	33	31	,	,	PUNCT
bptjm-33	33	32	which	which	PRON
bptjm-33	33	33	has	have	VERB
bptjm-33	33	34	broad	broad	ADJ
bptjm-33	33	35	therapeutic	therapeutic	ADJ
bptjm-33	33	36	and	and	CCONJ
bptjm-33	33	37	diagnostic	diagnostic	ADJ
bptjm-33	33	38	potential	potential	NOUN
bptjm-33	33	39	that	that	PRON
bptjm-33	33	40	remain	remain	VERB
bptjm-33	33	41	to	to	PART
bptjm-33	33	42	be	be	AUX
bptjm-33	33	43	unlocked	unlock	VERB
bptjm-33	33	44	.	.	PUNCT
bptjm-33	34	1	2	2	X
bptjm-33	34	2	.	.	X
bptjm-33	34	3	pathophysiology	pathophysiology	NOUN
bptjm-33	34	4	of	of	ADP
bptjm-33	34	5	alzheimer	alzheimer	PROPN
bptjm-33	34	6	’s	’s	PART
bptjm-33	34	7	disease	disease	NOUN
bptjm-33	34	8	2.1	2.1	NUM
bptjm-33	34	9	.	.	PUNCT
bptjm-33	35	1	amyloid	amyloid	NOUN
bptjm-33	35	2	plaques	plaque	NOUN
bptjm-33	35	3	amyloid	amyloid	NOUN
bptjm-33	35	4	pathogenesis	pathogenesis	NOUN
bptjm-33	35	5	starts	start	VERB
bptjm-33	35	6	with	with	ADP
bptjm-33	35	7	altered	altered	ADJ
bptjm-33	35	8	cleavage	cleavage	NOUN
bptjm-33	35	9	of	of	ADP
bptjm-33	35	10	aβ	aβ	NOUN
bptjm-33	35	11	peptide	peptide	NOUN
bptjm-33	35	12	from	from	ADP
bptjm-33	35	13	the	the	DET
bptjm-33	35	14	internal	internal	ADJ
bptjm-33	35	15	transmembrane	transmembrane	ADJ
bptjm-33	35	16	protein	protein	NOUN
bptjm-33	35	17	amyloid	amyloid	NOUN
bptjm-33	35	18	precursor	precursor	NOUN
bptjm-33	35	19	protein	protein	NOUN
bptjm-33	35	20	(	(	PUNCT
bptjm-33	35	21	app	app	PROPN
bptjm-33	35	22	)	)	PUNCT
bptjm-33	35	23	by	by	ADP
bptjm-33	35	24	the	the	DET
bptjm-33	35	25	alpha	alpha	NOUN
bptjm-33	35	26	,	,	PUNCT
bptjm-33	35	27	beta	beta	NOUN
bptjm-33	35	28	,	,	PUNCT
bptjm-33	35	29	and	and	CCONJ
bptjm-33	35	30	gamma	gamma	PROPN
bptjm-33	35	31	secretase10	secretase10	PROPN
bptjm-33	35	32	.	.	PUNCT
bptjm-33	36	1	two	two	NUM
bptjm-33	36	2	main	main	ADJ
bptjm-33	36	3	types	type	NOUN
bptjm-33	36	4	of	of	ADP
bptjm-33	36	5	aβ	aβ	DET
bptjm-33	36	6	polymers	polymer	NOUN
bptjm-33	36	7	are	be	AUX
bptjm-33	36	8	involved	involve	VERB
bptjm-33	36	9	in	in	ADP
bptjm-33	36	10	plaque	plaque	NOUN
bptjm-33	36	11	formation	formation	NOUN
bptjm-33	36	12	and	and	CCONJ
bptjm-33	36	13	induced	induce	VERB
bptjm-33	36	14	neurotoxicity	neurotoxicity	NOUN
bptjm-33	36	15	.	.	PUNCT
bptjm-33	37	1	aβ40	aβ40	PROPN
bptjm-33	37	2	is	be	AUX
bptjm-33	37	3	more	more	ADV
bptjm-33	37	4	abundant	abundant	ADJ
bptjm-33	37	5	and	and	CCONJ
bptjm-33	37	6	less	less	ADV
bptjm-33	37	7	neurotoxic	neurotoxic	ADJ
bptjm-33	37	8	than	than	ADP
bptjm-33	37	9	aβ42	aβ42	PROPN
bptjm-33	37	10	,	,	PUNCT
bptjm-33	37	11	which	which	PRON
bptjm-33	37	12	is	be	AUX
bptjm-33	37	13	highly	highly	ADV
bptjm-33	37	14	insoluble	insoluble	ADJ
bptjm-33	37	15	and	and	CCONJ
bptjm-33	37	16	neurotoxic	neurotoxic	ADJ
bptjm-33	37	17	.	.	PUNCT
bptjm-33	38	1	aβ40	aβ40	ADJ
bptjm-33	38	2	/	/	SYM
bptjm-33	38	3	aβ42	aβ42	PROPN
bptjm-33	38	4	aggregation	aggregation	NOUN
bptjm-33	38	5	blocks	block	VERB
bptjm-33	38	6	ion	ion	NOUN
bptjm-33	38	7	channels	channel	NOUN
bptjm-33	38	8	,	,	PUNCT
bptjm-33	38	9	alters	alter	VERB
bptjm-33	38	10	calcium	calcium	NOUN
bptjm-33	38	11	homeostasis	homeostasis	NOUN
bptjm-33	38	12	,	,	PUNCT
bptjm-33	38	13	increases	increase	VERB
bptjm-33	38	14	mitochondrial	mitochondrial	ADJ
bptjm-33	38	15	oxidative	oxidative	ADJ
bptjm-33	38	16	stress	stress	NOUN
bptjm-33	38	17	,	,	PUNCT
bptjm-33	38	18	and	and	CCONJ
bptjm-33	38	19	diminishes	diminish	VERB
bptjm-33	38	20	energy	energy	NOUN
bptjm-33	38	21	metabolism	metabolism	NOUN
bptjm-33	38	22	and	and	CCONJ
bptjm-33	38	23	glucose	glucose	NOUN
bptjm-33	38	24	regulation	regulation	NOUN
bptjm-33	38	25	,	,	PUNCT
bptjm-33	38	26	which	which	PRON
bptjm-33	38	27	promotes	promote	VERB
bptjm-33	38	28	neuronal	neuronal	ADJ
bptjm-33	38	29	cell	cell	NOUN
bptjm-33	38	30	death11	death11	NOUN
bptjm-33	38	31	.	.	PUNCT
bptjm-33	39	1	under	under	ADP
bptjm-33	39	2	normal	normal	ADJ
bptjm-33	39	3	conditions	condition	NOUN
bptjm-33	39	4	,	,	PUNCT
bptjm-33	39	5	proteolysis	proteolysis	NOUN
bptjm-33	39	6	of	of	ADP
bptjm-33	39	7	app	app	NOUN
bptjm-33	39	8	by	by	ADP
bptjm-33	39	9	either	either	CCONJ
bptjm-33	39	10	alpha	alpha	NOUN
bptjm-33	39	11	or	or	CCONJ
bptjm-33	39	12	β	β	NOUN
bptjm-33	39	13	-	-	NOUN
bptjm-33	39	14	secretases	secretase	NOUN
bptjm-33	39	15	(	(	PUNCT
bptjm-33	39	16	bace1	bace1	NOUN
bptjm-33	39	17	)	)	PUNCT
bptjm-33	39	18	cleaves	cleave	VERB
bptjm-33	39	19	off	off	ADP
bptjm-33	39	20	small	small	ADJ
bptjm-33	39	21	nontoxic	nontoxic	ADJ
bptjm-33	39	22	fragments	fragment	NOUN
bptjm-33	39	23	.	.	PUNCT
bptjm-33	40	1	however	however	ADV
bptjm-33	40	2	,	,	PUNCT
bptjm-33	40	3	altered	altered	ADJ
bptjm-33	40	4	cleavage	cleavage	NOUN
bptjm-33	40	5	of	of	ADP
bptjm-33	40	6	app	app	NOUN
bptjm-33	40	7	by	by	ADP
bptjm-33	40	8	β	β	NOUN
bptjm-33	40	9	followed	follow	VERB
bptjm-33	40	10	by	by	ADP
bptjm-33	40	11	γ	γ	NOUN
bptjm-33	40	12	-	-	PUNCT
bptjm-33	40	13	secretases	secretase	NOUN
bptjm-33	40	14	results	result	NOUN
bptjm-33	40	15	in	in	ADP
bptjm-33	40	16	42	42	NUM
bptjm-33	40	17	amino	amino	NOUN
bptjm-33	40	18	acid	acid	NOUN
bptjm-33	40	19	peptides	peptide	NOUN
bptjm-33	40	20	(	(	PUNCT
bptjm-33	40	21	aβ42	aβ42	PROPN
bptjm-33	40	22	)	)	PUNCT
bptjm-33	40	23	which	which	PRON
bptjm-33	40	24	then	then	ADV
bptjm-33	40	25	aggregate	aggregate	VERB
bptjm-33	40	26	to	to	PART
bptjm-33	40	27	form	form	VERB
bptjm-33	40	28	oligomers	oligomer	NOUN
bptjm-33	40	29	that	that	PRON
bptjm-33	40	30	diffuse	diffuse	VERB
bptjm-33	40	31	into	into	ADP
bptjm-33	40	32	synaptic	synaptic	ADJ
bptjm-33	40	33	clefts	cleft	NOUN
bptjm-33	40	34	and	and	CCONJ
bptjm-33	40	35	interfere	interfere	VERB
bptjm-33	40	36	with	with	ADP
bptjm-33	40	37	synaptic	synaptic	ADJ
bptjm-33	40	38	signaling	signaling	NOUN
bptjm-33	40	39	.	.	PUNCT
bptjm-33	41	1	increased	increase	VERB
bptjm-33	41	2	level	level	NOUN
bptjm-33	41	3	of	of	ADP
bptjm-33	41	4	aβ42	aβ42	PROPN
bptjm-33	41	5	leads	lead	VERB
bptjm-33	41	6	to	to	ADP
bptjm-33	41	7	the	the	DET
bptjm-33	41	8	polymerization	polymerization	NOUN
bptjm-33	41	9	of	of	ADP
bptjm-33	41	10	insoluble	insoluble	ADJ
bptjm-33	41	11	amyloid	amyloid	NOUN
bptjm-33	41	12	fibrils	fibril	NOUN
bptjm-33	41	13	that	that	PRON
bptjm-33	41	14	causes	cause	VERB
bptjm-33	41	15	neuronal	neuronal	ADJ
bptjm-33	41	16	toxicity10,11,12	toxicity10,11,12	NOUN
bptjm-33	41	17	.	.	PUNCT
bptjm-33	42	1	accumulation	accumulation	NOUN
bptjm-33	42	2	of	of	ADP
bptjm-33	42	3	these	these	DET
bptjm-33	42	4	amyloid	amyloid	NOUN
bptjm-33	42	5	plaques	plaque	NOUN
bptjm-33	42	6	initially	initially	ADV
bptjm-33	42	7	occurs	occur	VERB
bptjm-33	42	8	in	in	ADP
bptjm-33	42	9	the	the	DET
bptjm-33	42	10	basal	basal	NOUN
bptjm-33	42	11	,	,	PUNCT
bptjm-33	42	12	temporal	temporal	ADJ
bptjm-33	42	13	,	,	PUNCT
bptjm-33	42	14	and	and	CCONJ
bptjm-33	42	15	orbitofrontal	orbitofrontal	ADJ
bptjm-33	42	16	neocortex	neocortex	NOUN
bptjm-33	42	17	region	region	NOUN
bptjm-33	42	18	of	of	ADP
bptjm-33	42	19	the	the	DET
bptjm-33	42	20	brain	brain	NOUN
bptjm-33	42	21	and	and	CCONJ
bptjm-33	42	22	later	later	ADV
bptjm-33	42	23	progresses	progress	NOUN
bptjm-33	42	24	throughout	throughout	ADP
bptjm-33	42	25	the	the	DET
bptjm-33	42	26	hippocampus	hippocampus	NOUN
bptjm-33	42	27	,	,	PUNCT
bptjm-33	42	28	amygdala	amygdala	NOUN
bptjm-33	42	29	,	,	PUNCT
bptjm-33	42	30	and	and	CCONJ
bptjm-33	42	31	cerebral	cerebral	ADJ
bptjm-33	42	32	cortex12	cortex12	ADJ
bptjm-33	42	33	.	.	PUNCT
bptjm-33	43	1	sustained	sustain	VERB
bptjm-33	43	2	elevation	elevation	NOUN
bptjm-33	43	3	and	and	CCONJ
bptjm-33	43	4	continuous	continuous	ADJ
bptjm-33	43	5	aggregation	aggregation	NOUN
bptjm-33	43	6	of	of	ADP
bptjm-33	43	7	dense	dense	ADJ
bptjm-33	43	8	amyloid	amyloid	NOUN
bptjm-33	43	9	plaques	plaque	NOUN
bptjm-33	43	10	can	can	AUX
bptjm-33	43	11	stimulate	stimulate	VERB
bptjm-33	43	12	a	a	DET
bptjm-33	43	13	chronic	chronic	ADJ
bptjm-33	43	14	response	response	NOUN
bptjm-33	43	15	of	of	ADP
bptjm-33	43	16	the	the	DET
bptjm-33	43	17	innate	innate	ADJ
bptjm-33	43	18	immune	immune	ADJ
bptjm-33	43	19	system	system	NOUN
bptjm-33	43	20	by	by	ADP
bptjm-33	43	21	inducing	induce	VERB
bptjm-33	43	22	astrocytes	astrocyte	NOUN
bptjm-33	43	23	and	and	CCONJ
bptjm-33	43	24	microglia	microglia	ADJ
bptjm-33	43	25	recruitment	recruitment	NOUN
bptjm-33	43	26	surrounding	surround	VERB
bptjm-33	43	27	the	the	DET
bptjm-33	43	28	plaques	plaque	NOUN
bptjm-33	43	29	.	.	PUNCT
bptjm-33	44	1	this	this	DET
bptjm-33	44	2	results	result	VERB
bptjm-33	44	3	in	in	ADP
bptjm-33	44	4	the	the	DET
bptjm-33	44	5	increased	increase	VERB
bptjm-33	44	6	level	level	NOUN
bptjm-33	44	7	of	of	ADP
bptjm-33	44	8	local	local	ADJ
bptjm-33	44	9	inflammatory	inflammatory	ADJ
bptjm-33	44	10	response	response	NOUN
bptjm-33	44	11	due	due	ADP
bptjm-33	44	12	to	to	ADP
bptjm-33	44	13	the	the	DET
bptjm-33	44	14	elevated	elevated	ADJ
bptjm-33	44	15	release	release	NOUN
bptjm-33	44	16	of	of	ADP
bptjm-33	44	17	inflammation	inflammation	NOUN
bptjm-33	44	18	related	relate	VERB
bptjm-33	44	19	mediators	mediator	NOUN
bptjm-33	44	20	,	,	PUNCT
bptjm-33	44	21	such	such	ADJ
bptjm-33	44	22	as	as	ADP
bptjm-33	44	23	complement	complement	NOUN
bptjm-33	44	24	factors	factor	NOUN
bptjm-33	44	25	,	,	PUNCT
bptjm-33	44	26	eicosanoids	eicosanoid	NOUN
bptjm-33	44	27	,	,	PUNCT
bptjm-33	44	28	chemokines	chemokine	NOUN
bptjm-33	44	29	,	,	PUNCT
bptjm-33	44	30	and	and	CCONJ
bptjm-33	44	31	proinflammatory	proinflammatory	ADJ
bptjm-33	44	32	cytokines	cytokine	NOUN
bptjm-33	44	33	,	,	PUNCT
bptjm-33	44	34	which	which	PRON
bptjm-33	44	35	can	can	AUX
bptjm-33	44	36	disrupt	disrupt	VERB
bptjm-33	44	37	microglial	microglial	ADJ
bptjm-33	44	38	clearance	clearance	NOUN
bptjm-33	44	39	of	of	ADP
bptjm-33	44	40	amyloid	amyloid	NOUN
bptjm-33	44	41	plaques	plaque	NOUN
bptjm-33	44	42	,	,	PUNCT
bptjm-33	44	43	while	while	SCONJ
bptjm-33	44	44	also	also	ADV
bptjm-33	44	45	increasing	increase	VERB
bptjm-33	44	46	microglia	microglia	ADJ
bptjm-33	44	47	mediated	mediate	VERB
bptjm-33	44	48	neuronal	neuronal	ADJ
bptjm-33	44	49	death	death	NOUN
bptjm-33	44	50	,	,	PUNCT
bptjm-33	44	51	damage	damage	NOUN
bptjm-33	44	52	to	to	ADP
bptjm-33	44	53	axons	axon	NOUN
bptjm-33	44	54	and	and	CCONJ
bptjm-33	44	55	dendrites	dendrite	NOUN
bptjm-33	44	56	,	,	PUNCT
bptjm-33	44	57	synaptic	synaptic	ADJ
bptjm-33	44	58	loss	loss	NOUN
bptjm-33	44	59	,	,	PUNCT
bptjm-33	44	60	and	and	CCONJ
bptjm-33	44	61	neurotoxicity10,11	neurotoxicity10,11	NOUN
bptjm-33	44	62	.	.	PUNCT
bptjm-33	45	1	consequently	consequently	ADV
bptjm-33	45	2	,	,	PUNCT
bptjm-33	45	3	these	these	DET
bptjm-33	45	4	neuronal	neuronal	ADJ
bptjm-33	45	5	dysfunction	dysfunction	NOUN
bptjm-33	45	6	inhibits	inhibit	VERB
bptjm-33	45	7	cell	cell	NOUN
bptjm-33	45	8	synaptic	synaptic	ADJ
bptjm-33	45	9	communication	communication	NOUN
bptjm-33	45	10	,	,	PUNCT
bptjm-33	45	11	contributing	contribute	VERB
bptjm-33	45	12	greatly	greatly	ADV
bptjm-33	45	13	to	to	ADP
bptjm-33	45	14	ad	ad	NOUN
bptjm-33	45	15	pathogenesis	pathogenesis	NOUN
bptjm-33	45	16	.	.	PUNCT
bptjm-33	46	1	berkeley	berkeley	PROPN
bptjm-33	46	2	pharma	pharma	PROPN
bptjm-33	46	3	tech	tech	PROPN
bptjm-33	46	4	journal	journal	NOUN
bptjm-33	46	5	of	of	ADP
bptjm-33	46	6	medicine	medicine	NOUN
bptjm-33	46	7	|	|	ADV
bptjm-33	46	8	52	52	NUM
bptjm-33	46	9	2.2	2.2	NUM
bptjm-33	46	10	.	.	PUNCT
bptjm-33	47	1	neurofibrillary	neurofibrillary	ADJ
bptjm-33	47	2	tangles	tangle	NOUN
bptjm-33	47	3	(	(	PUNCT
bptjm-33	47	4	nfts	nft	NOUN
bptjm-33	47	5	)	)	PUNCT
bptjm-33	47	6	tau	tau	PROPN
bptjm-33	47	7	protein	protein	NOUN
bptjm-33	47	8	,	,	PUNCT
bptjm-33	47	9	encoded	encode	VERB
bptjm-33	47	10	by	by	ADP
bptjm-33	47	11	the	the	DET
bptjm-33	47	12	microtubule	microtubule	NOUN
bptjm-33	47	13	associated	associate	VERB
bptjm-33	47	14	protein	protein	NOUN
bptjm-33	47	15	tau	tau	PROPN
bptjm-33	47	16	(	(	PUNCT
bptjm-33	47	17	mapt	mapt	NOUN
bptjm-33	47	18	)	)	PUNCT
bptjm-33	47	19	gene	gene	NOUN
bptjm-33	47	20	,	,	PUNCT
bptjm-33	47	21	is	be	AUX
bptjm-33	47	22	a	a	DET
bptjm-33	47	23	microtubule	microtubule	NOUN
bptjm-33	47	24	-	-	PUNCT
bptjm-33	47	25	associated	associate	VERB
bptjm-33	47	26	protein	protein	NOUN
bptjm-33	47	27	that	that	PRON
bptjm-33	47	28	can	can	AUX
bptjm-33	47	29	form	form	VERB
bptjm-33	47	30	insoluble	insoluble	ADJ
bptjm-33	47	31	filaments	filament	NOUN
bptjm-33	47	32	that	that	PRON
bptjm-33	47	33	accumulate	accumulate	VERB
bptjm-33	47	34	as	as	ADP
bptjm-33	47	35	nfts	nft	NOUN
bptjm-33	47	36	.	.	PUNCT
bptjm-33	48	1	tau	tau	PROPN
bptjm-33	48	2	protein	protein	NOUN
bptjm-33	48	3	facilitates	facilitate	VERB
bptjm-33	48	4	the	the	DET
bptjm-33	48	5	maintenance	maintenance	NOUN
bptjm-33	48	6	of	of	ADP
bptjm-33	48	7	neuronal	neuronal	ADJ
bptjm-33	48	8	structure	structure	NOUN
bptjm-33	48	9	and	and	CCONJ
bptjm-33	48	10	function	function	NOUN
bptjm-33	48	11	.	.	PUNCT
bptjm-33	49	1	in	in	ADP
bptjm-33	49	2	alzheimer	alzheimer	PROPN
bptjm-33	49	3	’s	’s	PART
bptjm-33	49	4	,	,	PUNCT
bptjm-33	49	5	the	the	DET
bptjm-33	49	6	abundance	abundance	NOUN
bptjm-33	49	7	of	of	ADP
bptjm-33	49	8	aβ	aβ	NOUN
bptjm-33	49	9	plaques	plaque	NOUN
bptjm-33	49	10	in	in	ADP
bptjm-33	49	11	the	the	DET
bptjm-33	49	12	cell	cell	NOUN
bptjm-33	49	13	causes	cause	VERB
bptjm-33	49	14	the	the	DET
bptjm-33	49	15	tau	tau	PROPN
bptjm-33	49	16	protein	protein	NOUN
bptjm-33	49	17	to	to	PART
bptjm-33	49	18	become	become	VERB
bptjm-33	49	19	hyperphosphorylated	hyperphosphorylated	ADJ
bptjm-33	49	20	,	,	PUNCT
bptjm-33	49	21	leading	lead	VERB
bptjm-33	49	22	to	to	ADP
bptjm-33	49	23	oligomerization	oligomerization	NOUN
bptjm-33	49	24	.	.	PUNCT
bptjm-33	50	1	consequently	consequently	ADV
bptjm-33	50	2	,	,	PUNCT
bptjm-33	50	3	the	the	DET
bptjm-33	50	4	loss	loss	NOUN
bptjm-33	50	5	of	of	ADP
bptjm-33	50	6	its	its	PRON
bptjm-33	50	7	affinity	affinity	NOUN
bptjm-33	50	8	for	for	ADP
bptjm-33	50	9	tubulin	tubulin	NOUN
bptjm-33	50	10	leads	lead	VERB
bptjm-33	50	11	to	to	ADP
bptjm-33	50	12	dissociation	dissociation	NOUN
bptjm-33	50	13	of	of	ADP
bptjm-33	50	14	tubule	tubule	ADJ
bptjm-33	50	15	subunits	subunit	NOUN
bptjm-33	50	16	that	that	PRON
bptjm-33	50	17	eventually	eventually	ADV
bptjm-33	50	18	fall	fall	VERB
bptjm-33	50	19	apart	apart	ADV
bptjm-33	50	20	and	and	CCONJ
bptjm-33	50	21	form	form	VERB
bptjm-33	50	22	large	large	ADJ
bptjm-33	50	23	fragments	fragment	NOUN
bptjm-33	50	24	of	of	ADP
bptjm-33	50	25	tau	tau	PROPN
bptjm-33	50	26	filaments	filament	NOUN
bptjm-33	50	27	that	that	PRON
bptjm-33	50	28	can	can	AUX
bptjm-33	50	29	aggregate	aggregate	VERB
bptjm-33	50	30	into	into	ADP
bptjm-33	50	31	nfts	nft	NOUN
bptjm-33	50	32	.	.	PUNCT
bptjm-33	51	1	nfts	nft	NOUN
bptjm-33	51	2	are	be	AUX
bptjm-33	51	3	straight	straight	ADJ
bptjm-33	51	4	,	,	PUNCT
bptjm-33	51	5	fibrillary	fibrillary	ADJ
bptjm-33	51	6	,	,	PUNCT
bptjm-33	51	7	and	and	CCONJ
bptjm-33	51	8	highly	highly	ADV
bptjm-33	51	9	insoluble	insoluble	ADJ
bptjm-33	51	10	patches	patch	NOUN
bptjm-33	51	11	in	in	ADP
bptjm-33	51	12	the	the	DET
bptjm-33	51	13	neuronal	neuronal	ADJ
bptjm-33	51	14	cytoplasm	cytoplasm	NOUN
bptjm-33	51	15	that	that	PRON
bptjm-33	51	16	are	be	AUX
bptjm-33	51	17	composed	compose	VERB
bptjm-33	51	18	of	of	ADP
bptjm-33	51	19	paired	pair	VERB
bptjm-33	51	20	helical	helical	ADJ
bptjm-33	51	21	fragments	fragment	NOUN
bptjm-33	51	22	(	(	PUNCT
bptjm-33	51	23	phfs	phfs	NOUN
bptjm-33	51	24	)	)	PUNCT
bptjm-33	51	25	of	of	ADP
bptjm-33	51	26	tau	tau	PROPN
bptjm-33	51	27	fibrils	fibril	VERB
bptjm-33	51	28	approximately	approximately	ADV
bptjm-33	51	29	20	20	NUM
bptjm-33	51	30	nm	nm	NOUN
bptjm-33	51	31	in	in	ADP
bptjm-33	51	32	diameter	diameter	NOUN
bptjm-33	51	33	.	.	PUNCT
bptjm-33	52	1	they	they	PRON
bptjm-33	52	2	spread	spread	VERB
bptjm-33	52	3	throughout	throughout	ADP
bptjm-33	52	4	the	the	DET
bptjm-33	52	5	brain	brain	NOUN
bptjm-33	52	6	as	as	ADP
bptjm-33	52	7	ad	ad	NOUN
bptjm-33	52	8	progresses	progress	NOUN
bptjm-33	52	9	,	,	PUNCT
bptjm-33	52	10	beginning	begin	VERB
bptjm-33	52	11	near	near	ADP
bptjm-33	52	12	the	the	DET
bptjm-33	52	13	entorhinal	entorhinal	ADJ
bptjm-33	52	14	cortex	cortex	NOUN
bptjm-33	52	15	,	,	PUNCT
bptjm-33	52	16	leading	lead	VERB
bptjm-33	52	17	to	to	ADP
bptjm-33	52	18	abnormal	abnormal	ADJ
bptjm-33	52	19	loss	loss	NOUN
bptjm-33	52	20	of	of	ADP
bptjm-33	52	21	communication	communication	NOUN
bptjm-33	52	22	between	between	ADP
bptjm-33	52	23	neurons	neuron	NOUN
bptjm-33	52	24	and	and	CCONJ
bptjm-33	52	25	signal	signal	NOUN
bptjm-33	52	26	processing	processing	NOUN
bptjm-33	52	27	and	and	CCONJ
bptjm-33	52	28	finally	finally	ADV
bptjm-33	52	29	apoptosis	apoptosis	VERB
bptjm-33	52	30	,	,	PUNCT
bptjm-33	52	31	cell	cell	NOUN
bptjm-33	52	32	death	death	NOUN
bptjm-33	52	33	,	,	PUNCT
bptjm-33	52	34	in	in	ADP
bptjm-33	52	35	neurons	neuron	NOUN
bptjm-33	52	36	.	.	PUNCT
bptjm-33	53	1	in	in	ADP
bptjm-33	53	2	addition	addition	NOUN
bptjm-33	53	3	,	,	PUNCT
bptjm-33	53	4	the	the	DET
bptjm-33	53	5	transfer	transfer	NOUN
bptjm-33	53	6	of	of	ADP
bptjm-33	53	7	hyperphosphorylated	hyperphosphorylated	ADJ
bptjm-33	53	8	tau	tau	PROPN
bptjm-33	53	9	proteins	protein	NOUN
bptjm-33	53	10	diffuse	diffuse	VERB
bptjm-33	53	11	to	to	ADP
bptjm-33	53	12	surrounding	surround	VERB
bptjm-33	53	13	cells	cell	NOUN
bptjm-33	53	14	and	and	CCONJ
bptjm-33	53	15	cause	cause	VERB
bptjm-33	53	16	damage	damage	NOUN
bptjm-33	53	17	to	to	ADP
bptjm-33	53	18	neuronal	neuronal	ADJ
bptjm-33	53	19	function	function	NOUN
bptjm-33	53	20	,	,	PUNCT
bptjm-33	53	21	contributing	contribute	VERB
bptjm-33	53	22	to	to	ADP
bptjm-33	53	23	the	the	DET
bptjm-33	53	24	onset	onset	NOUN
bptjm-33	53	25	of	of	ADP
bptjm-33	53	26	ad	ad	NOUN
bptjm-33	53	27	.	.	PUNCT
bptjm-33	54	1	genomic	genomic	ADJ
bptjm-33	54	2	studies	study	NOUN
bptjm-33	54	3	of	of	ADP
bptjm-33	54	4	brain	brain	NOUN
bptjm-33	54	5	tissues	tissue	NOUN
bptjm-33	54	6	of	of	ADP
bptjm-33	54	7	ad	ad	NOUN
bptjm-33	54	8	patients	patient	NOUN
bptjm-33	54	9	have	have	AUX
bptjm-33	54	10	found	find	VERB
bptjm-33	54	11	significant	significant	ADJ
bptjm-33	54	12	downregulation	downregulation	NOUN
bptjm-33	54	13	of	of	ADP
bptjm-33	54	14	mirna-124	mirna-124	ADJ
bptjm-33	54	15	and	and	CCONJ
bptjm-33	54	16	mir-425	mir-425	NOUN
bptjm-33	54	17	-	-	PUNCT
bptjm-33	54	18	5p	5p	NUM
bptjm-33	54	19	,	,	PUNCT
bptjm-33	54	20	which	which	PRON
bptjm-33	54	21	under	under	ADP
bptjm-33	54	22	normal	normal	ADJ
bptjm-33	54	23	conditions	condition	NOUN
bptjm-33	54	24	inhibit	inhibit	VERB
bptjm-33	54	25	the	the	DET
bptjm-33	54	26	abnormal	abnormal	ADJ
bptjm-33	54	27	hyperphosphorylation	hyperphosphorylation	NOUN
bptjm-33	54	28	of	of	ADP
bptjm-33	54	29	tau	tau	PROPN
bptjm-33	54	30	protein	protein	NOUN
bptjm-33	54	31	.	.	PUNCT
bptjm-33	55	1	on	on	ADP
bptjm-33	55	2	the	the	DET
bptjm-33	55	3	other	other	ADJ
bptjm-33	55	4	hand	hand	NOUN
bptjm-33	55	5	,	,	PUNCT
bptjm-33	55	6	a	a	DET
bptjm-33	55	7	significant	significant	ADJ
bptjm-33	55	8	upregulation	upregulation	NOUN
bptjm-33	55	9	of	of	ADP
bptjm-33	55	10	mir-132	mir-132	NOUN
bptjm-33	55	11	and	and	CCONJ
bptjm-33	55	12	mir-125b	mir-125b	PROPN
bptjm-33	55	13	in	in	ADP
bptjm-33	55	14	ad	ad	NOUN
bptjm-33	55	15	patients	patient	NOUN
bptjm-33	55	16	has	have	AUX
bptjm-33	55	17	been	be	AUX
bptjm-33	55	18	found	find	VERB
bptjm-33	55	19	to	to	PART
bptjm-33	55	20	induce	induce	VERB
bptjm-33	55	21	tau	tau	PROPN
bptjm-33	55	22	protein	protein	NOUN
bptjm-33	55	23	phosphorylation	phosphorylation	NOUN
bptjm-33	55	24	and	and	CCONJ
bptjm-33	55	25	neuronal	neuronal	ADJ
bptjm-33	55	26	apoptosis	apoptosis	NOUN
bptjm-33	55	27	.	.	PUNCT
bptjm-33	56	1	moreover	moreover	ADV
bptjm-33	56	2	,	,	PUNCT
bptjm-33	56	3	mirnas	mirna	NOUN
bptjm-33	56	4	could	could	AUX
bptjm-33	56	5	promote	promote	VERB
bptjm-33	56	6	the	the	DET
bptjm-33	56	7	progression	progression	NOUN
bptjm-33	56	8	of	of	ADP
bptjm-33	56	9	ad	ad	NOUN
bptjm-33	56	10	by	by	ADP
bptjm-33	56	11	promoting	promote	VERB
bptjm-33	56	12	phosphorylation	phosphorylation	NOUN
bptjm-33	56	13	of	of	ADP
bptjm-33	56	14	the	the	DET
bptjm-33	56	15	tau	tau	PROPN
bptjm-33	56	16	protein	protein	NOUN
bptjm-33	56	17	.	.	PUNCT
bptjm-33	57	1	mir-483–5p	mir-483–5p	PROPN
bptjm-33	57	2	,	,	PUNCT
bptjm-33	57	3	mir-125b-5p	mir-125b-5p	PROPN
bptjm-33	57	4	and	and	CCONJ
bptjm-33	57	5	mir23b	mir23b	PROPN
bptjm-33	57	6	indirectly	indirectly	ADV
bptjm-33	57	7	regulates	regulate	VERB
bptjm-33	57	8	tau	tau	PROPN
bptjm-33	57	9	phosphorylation	phosphorylation	NOUN
bptjm-33	57	10	by	by	ADP
bptjm-33	57	11	targeting	target	VERB
bptjm-33	57	12	extracellular	extracellular	ADJ
bptjm-33	57	13	signal	signal	NOUN
bptjm-33	57	14	-	-	PUNCT
bptjm-33	57	15	regulated	regulate	VERB
bptjm-33	57	16	kinases	kinase	NOUN
bptjm-33	57	17	1	1	NUM
bptjm-33	57	18	and	and	CCONJ
bptjm-33	57	19	2(erk1/2	2(erk1/2	NUM
bptjm-33	57	20	)	)	PUNCT
bptjm-33	57	21	,	,	PUNCT
bptjm-33	57	22	protein	protein	NOUN
bptjm-33	57	23	phosphatase	phosphatase	NOUN
bptjm-33	57	24	methylesterase-1	methylesterase-1	PROPN
bptjm-33	57	25	(	(	PUNCT
bptjm-33	57	26	pme-1	pme-1	NOUN
bptjm-33	57	27	)	)	PUNCT
bptjm-33	57	28	and	and	CCONJ
bptjm-33	57	29	n	n	CCONJ
bptjm-33	57	30	-	-	PUNCT
bptjm-33	57	31	acetylglucosaminyltransferase	acetylglucosaminyltransferase	PROPN
bptjm-33	57	32	iii	iii	X
bptjm-33	57	33	(	(	PUNCT
bptjm-33	57	34	gntiii	gntiii	NOUN
bptjm-33	57	35	)	)	PUNCT
bptjm-33	57	36	signaling	signal	VERB
bptjm-33	57	37	pathways	pathway	NOUN
bptjm-33	57	38	,	,	PUNCT
bptjm-33	57	39	respectively13	respectively13	NOUN
bptjm-33	57	40	.	.	PUNCT
bptjm-33	58	1	amyloid	amyloid	NOUN
bptjm-33	58	2	pathology	pathology	PROPN
bptjm-33	58	3	appears	appear	VERB
bptjm-33	58	4	to	to	PART
bptjm-33	58	5	precede	precede	VERB
bptjm-33	58	6	that	that	PRON
bptjm-33	58	7	of	of	ADP
bptjm-33	58	8	tau	tau	PROPN
bptjm-33	58	9	,	,	PUNCT
bptjm-33	58	10	with	with	ADP
bptjm-33	58	11	nfts	nft	NOUN
bptjm-33	58	12	only	only	ADV
bptjm-33	58	13	being	be	AUX
bptjm-33	58	14	found	find	VERB
bptjm-33	58	15	in	in	ADP
bptjm-33	58	16	regions	region	NOUN
bptjm-33	58	17	where	where	SCONJ
bptjm-33	58	18	amyloid	amyloid	NOUN
bptjm-33	58	19	was	be	AUX
bptjm-33	58	20	already	already	ADV
bptjm-33	58	21	present	present	ADJ
bptjm-33	58	22	,	,	PUNCT
bptjm-33	58	23	but	but	CCONJ
bptjm-33	58	24	both	both	PRON
bptjm-33	58	25	aβ	aβ	PRON
bptjm-33	58	26	plaques	plaque	NOUN
bptjm-33	58	27	and	and	CCONJ
bptjm-33	58	28	neurofibrillary	neurofibrillary	ADJ
bptjm-33	58	29	tau	tau	PROPN
bptjm-33	58	30	tangles	tangle	NOUN
bptjm-33	58	31	are	be	AUX
bptjm-33	58	32	significant	significant	ADJ
bptjm-33	58	33	factors	factor	NOUN
bptjm-33	58	34	of	of	ADP
bptjm-33	58	35	the	the	DET
bptjm-33	58	36	pathogenesis	pathogenesis	NOUN
bptjm-33	58	37	of	of	ADP
bptjm-33	58	38	ad	ad	NOUN
bptjm-33	58	39	that	that	PRON
bptjm-33	58	40	lead	lead	VERB
bptjm-33	58	41	to	to	PART
bptjm-33	58	42	synapse	synapse	VERB
bptjm-33	58	43	loss	loss	NOUN
bptjm-33	58	44	and	and	CCONJ
bptjm-33	58	45	neuronal	neuronal	ADJ
bptjm-33	58	46	atrophy	atrophy	NOUN
bptjm-33	58	47	,	,	PUNCT
bptjm-33	58	48	especially	especially	ADV
bptjm-33	58	49	throughout	throughout	ADP
bptjm-33	58	50	the	the	DET
bptjm-33	58	51	hippocampus	hippocampus	NOUN
bptjm-33	58	52	and	and	CCONJ
bptjm-33	58	53	cerebral	cerebral	ADJ
bptjm-33	58	54	cortex11	cortex11	NOUN
bptjm-33	58	55	,	,	PUNCT
bptjm-33	58	56	12	12	NUM
bptjm-33	58	57	.	.	PUNCT
bptjm-33	59	1	berkeley	berkeley	PROPN
bptjm-33	59	2	pharma	pharma	PROPN
bptjm-33	59	3	tech	tech	PROPN
bptjm-33	59	4	journal	journal	NOUN
bptjm-33	59	5	of	of	ADP
bptjm-33	59	6	medicine	medicine	NOUN
bptjm-33	59	7	|	|	ADV
bptjm-33	59	8	53	53	NUM
bptjm-33	59	9	2.3	2.3	NUM
bptjm-33	59	10	.	.	PUNCT
bptjm-33	60	1	microglial	microglial	ADJ
bptjm-33	60	2	activation	activation	NOUN
bptjm-33	60	3	microglia	microglia	NOUN
bptjm-33	60	4	are	be	AUX
bptjm-33	60	5	macrophages	macrophage	NOUN
bptjm-33	60	6	that	that	PRON
bptjm-33	60	7	reside	reside	VERB
bptjm-33	60	8	in	in	ADP
bptjm-33	60	9	the	the	DET
bptjm-33	60	10	cns	cns	NOUN
bptjm-33	60	11	and	and	CCONJ
bptjm-33	60	12	play	play	VERB
bptjm-33	60	13	a	a	DET
bptjm-33	60	14	significant	significant	ADJ
bptjm-33	60	15	role	role	NOUN
bptjm-33	60	16	in	in	ADP
bptjm-33	60	17	maintaining	maintain	VERB
bptjm-33	60	18	neuronal	neuronal	ADJ
bptjm-33	60	19	plasticity	plasticity	NOUN
bptjm-33	60	20	,	,	PUNCT
bptjm-33	60	21	synapse	synapse	VERB
bptjm-33	60	22	remodeling	remodeling	NOUN
bptjm-33	60	23	,	,	PUNCT
bptjm-33	60	24	phagocytosis	phagocytosis	NOUN
bptjm-33	60	25	,	,	PUNCT
bptjm-33	60	26	and	and	CCONJ
bptjm-33	60	27	clearance	clearance	NOUN
bptjm-33	60	28	of	of	ADP
bptjm-33	60	29	aβ	aβ	DET
bptjm-33	60	30	plaques	plaque	NOUN
bptjm-33	60	31	in	in	ADP
bptjm-33	60	32	healthy	healthy	ADJ
bptjm-33	60	33	individuals	individual	NOUN
bptjm-33	60	34	.	.	PUNCT
bptjm-33	61	1	the	the	DET
bptjm-33	61	2	binding	binding	NOUN
bptjm-33	61	3	of	of	ADP
bptjm-33	61	4	microglia	microglia	NOUN
bptjm-33	61	5	to	to	ADP
bptjm-33	61	6	extracellular	extracellular	ADJ
bptjm-33	61	7	aβ	aβ	DET
bptjm-33	61	8	plaques	plaque	NOUN
bptjm-33	61	9	via	via	ADP
bptjm-33	61	10	cell	cell	NOUN
bptjm-33	61	11	-	-	PUNCT
bptjm-33	61	12	surface	surface	NOUN
bptjm-33	61	13	receptors	receptor	NOUN
bptjm-33	61	14	such	such	ADJ
bptjm-33	61	15	as	as	ADP
bptjm-33	61	16	scara1	scara1	NOUN
bptjm-33	61	17	,	,	PUNCT
bptjm-33	61	18	cd36	cd36	PROPN
bptjm-33	61	19	,	,	PUNCT
bptjm-33	61	20	cd14	cd14	PROPN
bptjm-33	61	21	,	,	PUNCT
bptjm-33	61	22	α6β1	α6β1	NOUN
bptjm-33	61	23	integrin	integrin	NOUN
bptjm-33	61	24	,	,	PUNCT
bptjm-33	61	25	cd47	cd47	PROPN
bptjm-33	61	26	,	,	PUNCT
bptjm-33	61	27	and	and	CCONJ
bptjm-33	61	28	toll	toll	NOUN
bptjm-33	61	29	-	-	PUNCT
bptjm-33	61	30	like	like	ADJ
bptjm-33	61	31	receptors	receptor	NOUN
bptjm-33	61	32	(	(	PUNCT
bptjm-33	61	33	tlrs	tlrs	NOUN
bptjm-33	61	34	)	)	PUNCT
bptjm-33	61	35	,	,	PUNCT
bptjm-33	61	36	a	a	DET
bptjm-33	61	37	class	class	NOUN
bptjm-33	61	38	of	of	ADP
bptjm-33	61	39	pattern	pattern	NOUN
bptjm-33	61	40	recognition	recognition	NOUN
bptjm-33	61	41	receptors	receptor	NOUN
bptjm-33	61	42	(	(	PUNCT
bptjm-33	61	43	prrs	prr	NOUN
bptjm-33	61	44	)	)	PUNCT
bptjm-33	61	45	that	that	PRON
bptjm-33	61	46	ignites	ignite	VERB
bptjm-33	61	47	innate	innate	ADJ
bptjm-33	61	48	immune	immune	ADJ
bptjm-33	61	49	response	response	NOUN
bptjm-33	61	50	,	,	PUNCT
bptjm-33	61	51	initiates	initiate	VERB
bptjm-33	61	52	the	the	DET
bptjm-33	61	53	endocytosis	endocytosis	NOUN
bptjm-33	61	54	of	of	ADP
bptjm-33	61	55	aβ	aβ	NOUN
bptjm-33	61	56	oligomers	oligomer	NOUN
bptjm-33	61	57	and	and	CCONJ
bptjm-33	61	58	nfts	nft	NOUN
bptjm-33	61	59	for	for	ADP
bptjm-33	61	60	degradation	degradation	NOUN
bptjm-33	61	61	by	by	ADP
bptjm-33	61	62	microglial	microglial	ADJ
bptjm-33	61	63	proteases	protease	NOUN
bptjm-33	61	64	such	such	ADJ
bptjm-33	61	65	as	as	ADP
bptjm-33	61	66	neurolysin	neurolysin	NOUN
bptjm-33	61	67	and	and	CCONJ
bptjm-33	61	68	insulin	insulin	NOUN
bptjm-33	61	69	-	-	PUNCT
bptjm-33	61	70	degrading	degrade	VERB
bptjm-33	61	71	enzymes11	enzymes11	NOUN
bptjm-33	61	72	.	.	PUNCT
bptjm-33	62	1	however	however	ADV
bptjm-33	62	2	,	,	PUNCT
bptjm-33	62	3	under	under	ADP
bptjm-33	62	4	pathological	pathological	ADJ
bptjm-33	62	5	conditions	condition	NOUN
bptjm-33	62	6	,	,	PUNCT
bptjm-33	62	7	the	the	DET
bptjm-33	62	8	phagocytotic	phagocytotic	ADJ
bptjm-33	62	9	functioning	functioning	NOUN
bptjm-33	62	10	of	of	ADP
bptjm-33	62	11	the	the	DET
bptjm-33	62	12	aβ	aβ	NOUN
bptjm-33	62	13	oligomers	oligomer	NOUN
bptjm-33	62	14	by	by	ADP
bptjm-33	62	15	the	the	DET
bptjm-33	62	16	microglia	microglia	NOUN
bptjm-33	62	17	is	be	AUX
bptjm-33	62	18	weakened	weaken	VERB
bptjm-33	62	19	,	,	PUNCT
bptjm-33	62	20	and	and	CCONJ
bptjm-33	62	21	overexpressed	overexpresse	VERB
bptjm-33	62	22	aβ	aβ	PRON
bptjm-33	62	23	plaques	plaque	NOUN
bptjm-33	62	24	and	and	CCONJ
bptjm-33	62	25	nfts	nft	NOUN
bptjm-33	62	26	can	can	AUX
bptjm-33	62	27	lead	lead	VERB
bptjm-33	62	28	to	to	ADP
bptjm-33	62	29	microglial	microglial	ADJ
bptjm-33	62	30	activation	activation	NOUN
bptjm-33	62	31	around	around	ADP
bptjm-33	62	32	the	the	DET
bptjm-33	62	33	plaque	plaque	NOUN
bptjm-33	62	34	areas	area	NOUN
bptjm-33	62	35	and	and	CCONJ
bptjm-33	62	36	release	release	VERB
bptjm-33	62	37	inflammatory	inflammatory	ADJ
bptjm-33	62	38	factors	factor	NOUN
bptjm-33	62	39	such	such	ADJ
bptjm-33	62	40	as	as	ADP
bptjm-33	62	41	il-1β	il-1β	PROPN
bptjm-33	62	42	and	and	CCONJ
bptjm-33	62	43	tnf	tnf	PROPN
bptjm-33	62	44	-	-	PUNCT
bptjm-33	62	45	α	α	PROPN
bptjm-33	62	46	,	,	PUNCT
bptjm-33	62	47	which	which	PRON
bptjm-33	62	48	aggravate	aggravate	VERB
bptjm-33	62	49	neuronal	neuronal	ADJ
bptjm-33	62	50	damage	damage	NOUN
bptjm-33	62	51	and	and	CCONJ
bptjm-33	62	52	exacerbate	exacerbate	VERB
bptjm-33	62	53	ad	ad	NOUN
bptjm-33	62	54	pathology	pathology	NOUN
bptjm-33	62	55	by	by	ADP
bptjm-33	62	56	giving	give	VERB
bptjm-33	62	57	rise	rise	NOUN
bptjm-33	62	58	to	to	ADP
bptjm-33	62	59	increased	increase	VERB
bptjm-33	62	60	synaptic	synaptic	ADJ
bptjm-33	62	61	damage	damage	NOUN
bptjm-33	62	62	,	,	PUNCT
bptjm-33	62	63	oxidative	oxidative	ADJ
bptjm-33	62	64	stress	stress	NOUN
bptjm-33	62	65	,	,	PUNCT
bptjm-33	62	66	and	and	CCONJ
bptjm-33	62	67	neuroinflammation7	neuroinflammation7	PROPN
bptjm-33	62	68	.	.	PUNCT
bptjm-33	63	1	furthermore	furthermore	ADV
bptjm-33	63	2	,	,	PUNCT
bptjm-33	63	3	insufficient	insufficient	ADJ
bptjm-33	63	4	aβ	aβ	NOUN
bptjm-33	63	5	plaque	plaque	NOUN
bptjm-33	63	6	clearance	clearance	NOUN
bptjm-33	63	7	is	be	AUX
bptjm-33	63	8	observed	observe	VERB
bptjm-33	63	9	due	due	ADJ
bptjm-33	63	10	to	to	ADP
bptjm-33	63	11	elevated	elevated	ADJ
bptjm-33	63	12	levels	level	NOUN
bptjm-33	63	13	of	of	ADP
bptjm-33	63	14	localized	localized	ADJ
bptjm-33	63	15	cytokine	cytokine	ADJ
bptjm-33	63	16	concentrations	concentration	NOUN
bptjm-33	63	17	that	that	PRON
bptjm-33	63	18	downregulate	downregulate	VERB
bptjm-33	63	19	the	the	DET
bptjm-33	63	20	expression	expression	NOUN
bptjm-33	63	21	of	of	ADP
bptjm-33	63	22	aβ	aβ	NOUN
bptjm-33	63	23	phagocytosis	phagocytosis	NOUN
bptjm-33	63	24	receptors	receptor	NOUN
bptjm-33	63	25	,	,	PUNCT
bptjm-33	63	26	thus	thus	ADV
bptjm-33	63	27	decreasing	decrease	VERB
bptjm-33	63	28	aβ	aβ	DET
bptjm-33	63	29	clearance13	clearance13	NOUN
bptjm-33	63	30	.	.	PUNCT
bptjm-33	64	1	moreover	moreover	ADV
bptjm-33	64	2	,	,	PUNCT
bptjm-33	64	3	proliferation	proliferation	NOUN
bptjm-33	64	4	and	and	CCONJ
bptjm-33	64	5	activation	activation	NOUN
bptjm-33	64	6	of	of	ADP
bptjm-33	64	7	microglia	microglia	NOUN
bptjm-33	64	8	in	in	ADP
bptjm-33	64	9	the	the	DET
bptjm-33	64	10	brain	brain	NOUN
bptjm-33	64	11	can	can	AUX
bptjm-33	64	12	affect	affect	VERB
bptjm-33	64	13	insulin	insulin	NOUN
bptjm-33	64	14	receptor	receptor	NOUN
bptjm-33	64	15	substrate	substrate	NOUN
bptjm-33	64	16	1	1	NUM
bptjm-33	64	17	(	(	PUNCT
bptjm-33	64	18	irs-1	irs-1	NUM
bptjm-33	64	19	)	)	PUNCT
bptjm-33	64	20	and	and	CCONJ
bptjm-33	64	21	block	block	VERB
bptjm-33	64	22	intracellular	intracellular	ADJ
bptjm-33	64	23	insulin	insulin	NOUN
bptjm-33	64	24	signaling	signaling	NOUN
bptjm-33	64	25	,	,	PUNCT
bptjm-33	64	26	which	which	PRON
bptjm-33	64	27	has	have	VERB
bptjm-33	64	28	an	an	DET
bptjm-33	64	29	important	important	ADJ
bptjm-33	64	30	role	role	NOUN
bptjm-33	64	31	in	in	ADP
bptjm-33	64	32	neural	neural	ADJ
bptjm-33	64	33	health11	health11	NOUN
bptjm-33	64	34	.	.	PUNCT
bptjm-33	65	1	3	3	X
bptjm-33	65	2	.	.	X
bptjm-33	65	3	genetic	genetic	ADJ
bptjm-33	65	4	basis	basis	NOUN
bptjm-33	65	5	the	the	DET
bptjm-33	65	6	role	role	NOUN
bptjm-33	65	7	of	of	ADP
bptjm-33	65	8	genetics	genetic	NOUN
bptjm-33	65	9	in	in	ADP
bptjm-33	65	10	ad	ad	NOUN
bptjm-33	65	11	pathogenesis	pathogenesis	NOUN
bptjm-33	65	12	accounts	account	VERB
bptjm-33	65	13	for	for	ADP
bptjm-33	65	14	about	about	ADV
bptjm-33	65	15	70	70	NUM
bptjm-33	65	16	%	%	NOUN
bptjm-33	65	17	of	of	ADP
bptjm-33	65	18	the	the	DET
bptjm-33	65	19	ad	ad	NOUN
bptjm-33	65	20	cases	case	NOUN
bptjm-33	65	21	.	.	PUNCT
bptjm-33	66	1	most	most	ADJ
bptjm-33	66	2	cases	case	NOUN
bptjm-33	66	3	of	of	ADP
bptjm-33	66	4	early	early	ADJ
bptjm-33	66	5	onset	onset	NOUN
bptjm-33	66	6	ad	ad	NOUN
bptjm-33	66	7	(	(	PUNCT
bptjm-33	66	8	eoad	eoad	NOUN
bptjm-33	66	9	)	)	PUNCT
bptjm-33	66	10	are	be	AUX
bptjm-33	66	11	known	know	VERB
bptjm-33	66	12	to	to	PART
bptjm-33	66	13	be	be	AUX
bptjm-33	66	14	inherited	inherit	VERB
bptjm-33	66	15	in	in	ADP
bptjm-33	66	16	an	an	DET
bptjm-33	66	17	autosomal	autosomal	ADJ
bptjm-33	66	18	dominant	dominant	ADJ
bptjm-33	66	19	pattern	pattern	NOUN
bptjm-33	66	20	and	and	CCONJ
bptjm-33	66	21	mutations	mutation	NOUN
bptjm-33	66	22	in	in	ADP
bptjm-33	66	23	the	the	DET
bptjm-33	66	24	dominant	dominant	ADJ
bptjm-33	66	25	genes	gene	NOUN
bptjm-33	66	26	including	include	VERB
bptjm-33	66	27	amyloid	amyloid	NOUN
bptjm-33	66	28	precursor	precursor	NOUN
bptjm-33	66	29	protein	protein	NOUN
bptjm-33	66	30	(	(	PUNCT
bptjm-33	66	31	app	app	NOUN
bptjm-33	66	32	)	)	PUNCT
bptjm-33	66	33	,	,	PUNCT
bptjm-33	66	34	presenilin-1	presenilin-1	PROPN
bptjm-33	66	35	(	(	PUNCT
bptjm-33	66	36	psen-1	psen-1	NOUN
bptjm-33	66	37	)	)	PUNCT
bptjm-33	66	38	,	,	PUNCT
bptjm-33	66	39	presenilin-2	presenilin-2	X
bptjm-33	66	40	(	(	PUNCT
bptjm-33	66	41	psen-2)14	psen-2)14	ADJ
bptjm-33	66	42	,	,	PUNCT
bptjm-33	66	43	apolipoprotein	apolipoprotein	ADJ
bptjm-33	66	44	e	e	PROPN
bptjm-33	66	45	(	(	PUNCT
bptjm-33	66	46	apoe	apoe	ADJ
bptjm-33	66	47	)	)	PUNCT
bptjm-33	66	48	,	,	PUNCT
bptjm-33	66	49	clusterin	clusterin	NOUN
bptjm-33	66	50	(	(	PUNCT
bptjm-33	66	51	clu	clu	PROPN
bptjm-33	66	52	)	)	PUNCT
bptjm-33	66	53	,	,	PUNCT
bptjm-33	66	54	bridging	bridge	VERB
bptjm-33	66	55	integrator	integrator	NOUN
bptjm-33	66	56	1	1	NUM
bptjm-33	66	57	(	(	PUNCT
bptjm-33	66	58	bin1	bin1	PROPN
bptjm-33	66	59	)	)	PUNCT
bptjm-33	66	60	,	,	PUNCT
bptjm-33	66	61	and	and	CCONJ
bptjm-33	66	62	trem215	trem215	PROPN
bptjm-33	66	63	.	.	PROPN
bptjm-33	66	64	3.1	3.1	NUM
bptjm-33	66	65	.	.	PUNCT
bptjm-33	67	1	app	app	PROPN
bptjm-33	67	2	app	app	PROPN
bptjm-33	67	3	is	be	AUX
bptjm-33	67	4	a	a	DET
bptjm-33	67	5	transmembrane	transmembrane	ADJ
bptjm-33	67	6	protein	protein	NOUN
bptjm-33	67	7	cleaved	cleave	VERB
bptjm-33	67	8	by	by	ADP
bptjm-33	67	9	α-	α-	X
bptjm-33	67	10	,	,	PUNCT
bptjm-33	67	11	β-	β-	X
bptjm-33	67	12	,	,	PUNCT
bptjm-33	67	13	and	and	CCONJ
bptjm-33	67	14	γ	γ	NOUN
bptjm-33	67	15	-	-	NOUN
bptjm-33	67	16	secretase	secretase	NOUN
bptjm-33	67	17	that	that	PRON
bptjm-33	67	18	releases	release	VERB
bptjm-33	67	19	aβ	aβ	ADP
bptjm-33	67	20	and	and	CCONJ
bptjm-33	67	21	other	other	ADJ
bptjm-33	67	22	proteins	protein	NOUN
bptjm-33	67	23	and	and	CCONJ
bptjm-33	67	24	is	be	AUX
bptjm-33	67	25	encoded	encode	VERB
bptjm-33	67	26	by	by	ADP
bptjm-33	67	27	the	the	DET
bptjm-33	67	28	app	app	NOUN
bptjm-33	67	29	gene	gene	NOUN
bptjm-33	67	30	on	on	ADP
bptjm-33	67	31	chromosome	chromosome	NOUN
bptjm-33	67	32	21	21	NUM
bptjm-33	67	33	.	.	PUNCT
bptjm-33	68	1	twenty	twenty	NUM
bptjm-33	68	2	-	-	PUNCT
bptjm-33	68	3	five	five	NUM
bptjm-33	68	4	out	out	ADP
bptjm-33	68	5	of	of	ADP
bptjm-33	68	6	thirty	thirty	NUM
bptjm-33	68	7	mutations	mutation	NOUN
bptjm-33	68	8	have	have	AUX
bptjm-33	68	9	been	be	AUX
bptjm-33	68	10	found	find	VERB
bptjm-33	68	11	in	in	ADP
bptjm-33	68	12	the	the	DET
bptjm-33	68	13	app	app	NOUN
bptjm-33	68	14	gene	gene	NOUN
bptjm-33	68	15	to	to	PART
bptjm-33	68	16	be	be	AUX
bptjm-33	68	17	related	relate	VERB
bptjm-33	68	18	to	to	ADP
bptjm-33	68	19	ad	ad	NOUN
bptjm-33	68	20	,	,	PUNCT
bptjm-33	68	21	along	along	ADP
bptjm-33	68	22	with	with	ADP
bptjm-33	68	23	the	the	DET
bptjm-33	68	24	elevated	elevated	ADJ
bptjm-33	68	25	level	level	NOUN
bptjm-33	68	26	of	of	ADP
bptjm-33	68	27	insoluble	insoluble	ADJ
bptjm-33	68	28	aβ	aβ	NOUN
bptjm-33	68	29	aggregates	aggregate	NOUN
bptjm-33	68	30	.	.	PUNCT
bptjm-33	69	1	km670/671nl	km670/671nl	PROPN
bptjm-33	69	2	mutation	mutation	PROPN
bptjm-33	69	3	in	in	ADP
bptjm-33	69	4	mouse	mouse	NOUN
bptjm-33	69	5	models	model	NOUN
bptjm-33	69	6	has	have	AUX
bptjm-33	69	7	shown	show	VERB
bptjm-33	69	8	an	an	DET
bptjm-33	69	9	increasing	increase	VERB
bptjm-33	69	10	level	level	NOUN
bptjm-33	69	11	of	of	ADP
bptjm-33	69	12	berkeley	berkeley	PROPN
bptjm-33	69	13	pharma	pharma	PROPN
bptjm-33	69	14	tech	tech	NOUN
bptjm-33	69	15	journal	journal	NOUN
bptjm-33	69	16	of	of	ADP
bptjm-33	69	17	medicine	medicine	NOUN
bptjm-33	69	18	|	|	ADV
bptjm-33	69	19	54	54	NUM
bptjm-33	69	20	amyloid	amyloid	NOUN
bptjm-33	69	21	plaques	plaque	NOUN
bptjm-33	69	22	in	in	ADP
bptjm-33	69	23	the	the	DET
bptjm-33	69	24	hippocampus	hippocampus	NOUN
bptjm-33	69	25	and	and	CCONJ
bptjm-33	69	26	cortex	cortex	NOUN
bptjm-33	69	27	.	.	PUNCT
bptjm-33	70	1	a673v	a673v	PROPN
bptjm-33	70	2	,	,	PUNCT
bptjm-33	70	3	d678h	d678h	PROPN
bptjm-33	70	4	,	,	PUNCT
bptjm-33	70	5	d678n	d678n	PROPN
bptjm-33	70	6	,	,	PUNCT
bptjm-33	70	7	e682k	e682k	PROPN
bptjm-33	70	8	,	,	PUNCT
bptjm-33	70	9	and	and	CCONJ
bptjm-33	70	10	k687n	k687n	PROPN
bptjm-33	70	11	mutations	mutation	NOUN
bptjm-33	70	12	have	have	AUX
bptjm-33	70	13	shown	show	VERB
bptjm-33	70	14	cortical	cortical	ADJ
bptjm-33	70	15	atrophy	atrophy	NOUN
bptjm-33	70	16	,	,	PUNCT
bptjm-33	70	17	and	and	CCONJ
bptjm-33	70	18	e682k	e682k	PROPN
bptjm-33	70	19	has	have	AUX
bptjm-33	70	20	shown	show	VERB
bptjm-33	70	21	hippocampal	hippocampal	ADJ
bptjm-33	70	22	atrophy15	atrophy15	NOUN
bptjm-33	70	23	.	.	PUNCT
bptjm-33	71	1	moreover	moreover	ADV
bptjm-33	71	2	,	,	PUNCT
bptjm-33	71	3	a673v	a673v	NOUN
bptjm-33	71	4	mutations	mutation	NOUN
bptjm-33	71	5	have	have	AUX
bptjm-33	71	6	shown	show	VERB
bptjm-33	71	7	a	a	DET
bptjm-33	71	8	presence	presence	NOUN
bptjm-33	71	9	of	of	ADP
bptjm-33	71	10	nfts	nft	NOUN
bptjm-33	71	11	and	and	CCONJ
bptjm-33	71	12	aβ	aβ	NOUN
bptjm-33	71	13	,	,	PUNCT
bptjm-33	71	14	activation	activation	NOUN
bptjm-33	71	15	of	of	ADP
bptjm-33	71	16	microglia	microglia	NOUN
bptjm-33	71	17	and	and	CCONJ
bptjm-33	71	18	astrocytes	astrocyte	NOUN
bptjm-33	71	19	,	,	PUNCT
bptjm-33	71	20	and	and	CCONJ
bptjm-33	71	21	neuronal	neuronal	ADJ
bptjm-33	71	22	loss	loss	NOUN
bptjm-33	71	23	.	.	PUNCT
bptjm-33	72	1	other	other	ADJ
bptjm-33	72	2	mutations	mutation	NOUN
bptjm-33	72	3	such	such	ADJ
bptjm-33	72	4	as	as	ADP
bptjm-33	72	5	t714i	t714i	PROPN
bptjm-33	72	6	,	,	PUNCT
bptjm-33	72	7	v715a	v715a	PROPN
bptjm-33	72	8	,	,	PUNCT
bptjm-33	72	9	v715	v715	PROPN
bptjm-33	72	10	m	m	PROPN
bptjm-33	72	11	,	,	PUNCT
bptjm-33	72	12	v717i	v717i	PROPN
bptjm-33	72	13	,	,	PUNCT
bptjm-33	72	14	v717l	v717l	PROPN
bptjm-33	72	15	,	,	PUNCT
bptjm-33	72	16	l723p	l723p	PROPN
bptjm-33	72	17	,	,	PUNCT
bptjm-33	72	18	k724n	k724n	PROPN
bptjm-33	72	19	,	,	PUNCT
bptjm-33	72	20	and	and	CCONJ
bptjm-33	72	21	i716v	i716v	PROPN
bptjm-33	72	22	affect	affect	VERB
bptjm-33	72	23	the	the	DET
bptjm-33	72	24	γ	γ	PROPN
bptjm-33	72	25	-	-	ADJ
bptjm-33	72	26	secretase	secretase	ADJ
bptjm-33	72	27	cleavage	cleavage	NOUN
bptjm-33	72	28	site	site	NOUN
bptjm-33	72	29	,	,	PUNCT
bptjm-33	72	30	increasing	increase	VERB
bptjm-33	72	31	the	the	DET
bptjm-33	72	32	aβ42	aβ42	PROPN
bptjm-33	72	33	/	/	SYM
bptjm-33	72	34	aβ40	aβ40	PROPN
bptjm-33	72	35	ratio	ratio	NOUN
bptjm-33	72	36	.	.	PUNCT
bptjm-33	73	1	e693	e693	NUM
bptjm-33	73	2	g	g	NOUN
bptjm-33	73	3	,	,	PUNCT
bptjm-33	73	4	e693k	e693k	PROPN
bptjm-33	73	5	,	,	PUNCT
bptjm-33	73	6	d694n	d694n	NOUN
bptjm-33	73	7	,	,	PUNCT
bptjm-33	73	8	and	and	CCONJ
bptjm-33	73	9	a692	a692	PROPN
bptjm-33	73	10	g	g	NOUN
bptjm-33	73	11	mutations	mutation	NOUN
bptjm-33	73	12	affect	affect	VERB
bptjm-33	73	13	the	the	DET
bptjm-33	73	14	α	α	NOUN
bptjm-33	73	15	-	-	PUNCT
bptjm-33	73	16	secretase	secretase	ADJ
bptjm-33	73	17	cleavage	cleavage	NOUN
bptjm-33	73	18	site	site	NOUN
bptjm-33	73	19	,	,	PUNCT
bptjm-33	73	20	causing	cause	VERB
bptjm-33	73	21	polymorphic	polymorphic	ADJ
bptjm-33	73	22	aggregates	aggregate	NOUN
bptjm-33	73	23	that	that	PRON
bptjm-33	73	24	can	can	AUX
bptjm-33	73	25	disrupt	disrupt	VERB
bptjm-33	73	26	bilayer	bilayer	NOUN
bptjm-33	73	27	integrity	integrity	NOUN
bptjm-33	73	28	.	.	PUNCT
bptjm-33	74	1	meanwhile	meanwhile	ADV
bptjm-33	74	2	,	,	PUNCT
bptjm-33	74	3	one	one	NUM
bptjm-33	74	4	protective	protective	ADJ
bptjm-33	74	5	mutation	mutation	NOUN
bptjm-33	74	6	(	(	PUNCT
bptjm-33	74	7	a673	a673	PROPN
bptjm-33	74	8	t	t	PRON
bptjm-33	74	9	)	)	PUNCT
bptjm-33	74	10	has	have	AUX
bptjm-33	74	11	been	be	AUX
bptjm-33	74	12	identified	identify	VERB
bptjm-33	74	13	,	,	PUNCT
bptjm-33	74	14	which	which	PRON
bptjm-33	74	15	protects	protect	VERB
bptjm-33	74	16	against	against	ADP
bptjm-33	74	17	ad	ad	NOUN
bptjm-33	74	18	by	by	ADP
bptjm-33	74	19	decreasing	decrease	VERB
bptjm-33	74	20	aβ	aβ	NOUN
bptjm-33	74	21	,	,	PUNCT
bptjm-33	74	22	aβ40	aβ40	PROPN
bptjm-33	74	23	,	,	PUNCT
bptjm-33	74	24	and	and	CCONJ
bptjm-33	74	25	aβ42	aβ42	PROPN
bptjm-33	74	26	secretion15	secretion15	VERB
bptjm-33	74	27	.	.	PUNCT
bptjm-33	75	1	3.2	3.2	NUM
bptjm-33	75	2	.	.	PUNCT
bptjm-33	76	1	psen1	psen1	NOUN
bptjm-33	76	2	and	and	CCONJ
bptjm-33	76	3	psen2	psen2	NOUN
bptjm-33	76	4	presenilin	presenilin	NOUN
bptjm-33	76	5	genes	gene	NOUN
bptjm-33	76	6	(	(	PUNCT
bptjm-33	76	7	psen1	psen1	ADJ
bptjm-33	76	8	and	and	CCONJ
bptjm-33	76	9	psen2	psen2	NOUN
bptjm-33	76	10	)	)	PUNCT
bptjm-33	76	11	are	be	AUX
bptjm-33	76	12	part	part	NOUN
bptjm-33	76	13	of	of	ADP
bptjm-33	76	14	the	the	DET
bptjm-33	76	15	γ	γ	NOUN
bptjm-33	76	16	-	-	ADJ
bptjm-33	76	17	secretase	secretase	ADJ
bptjm-33	76	18	family	family	NOUN
bptjm-33	76	19	and	and	CCONJ
bptjm-33	76	20	were	be	AUX
bptjm-33	76	21	also	also	ADV
bptjm-33	76	22	found	find	VERB
bptjm-33	76	23	to	to	PART
bptjm-33	76	24	be	be	AUX
bptjm-33	76	25	mutated	mutate	VERB
bptjm-33	76	26	in	in	ADP
bptjm-33	76	27	ad14	ad14	PROPN
bptjm-33	76	28	.	.	PUNCT
bptjm-33	77	1	it	it	PRON
bptjm-33	77	2	has	have	AUX
bptjm-33	77	3	been	be	AUX
bptjm-33	77	4	found	find	VERB
bptjm-33	77	5	that	that	SCONJ
bptjm-33	77	6	ad	ad	NOUN
bptjm-33	77	7	patients	patient	NOUN
bptjm-33	77	8	may	may	AUX
bptjm-33	77	9	be	be	AUX
bptjm-33	77	10	predisposed	predispose	VERB
bptjm-33	77	11	to	to	ADP
bptjm-33	77	12	psen1	psen1	ADJ
bptjm-33	77	13	mutation	mutation	NOUN
bptjm-33	77	14	leading	lead	VERB
bptjm-33	77	15	to	to	ADP
bptjm-33	77	16	familial	familial	ADJ
bptjm-33	77	17	ad	ad	NOUN
bptjm-33	77	18	at	at	ADP
bptjm-33	77	19	a	a	DET
bptjm-33	77	20	young	young	ADJ
bptjm-33	77	21	age	age	NOUN
bptjm-33	77	22	.	.	PUNCT
bptjm-33	78	1	mutation	mutation	NOUN
bptjm-33	78	2	in	in	ADP
bptjm-33	78	3	the	the	DET
bptjm-33	78	4	psen1	psen1	ADJ
bptjm-33	78	5	gene	gene	NOUN
bptjm-33	78	6	is	be	AUX
bptjm-33	78	7	more	more	ADV
bptjm-33	78	8	common	common	ADJ
bptjm-33	78	9	,	,	PUNCT
bptjm-33	78	10	with	with	ADP
bptjm-33	78	11	more	more	ADJ
bptjm-33	78	12	than	than	ADP
bptjm-33	78	13	200	200	NUM
bptjm-33	78	14	mutations	mutation	NOUN
bptjm-33	78	15	identified	identify	VERB
bptjm-33	78	16	.	.	PUNCT
bptjm-33	79	1	on	on	ADP
bptjm-33	79	2	the	the	DET
bptjm-33	79	3	other	other	ADJ
bptjm-33	79	4	hand	hand	NOUN
bptjm-33	79	5	,	,	PUNCT
bptjm-33	79	6	a	a	DET
bptjm-33	79	7	rare	rare	ADJ
bptjm-33	79	8	form	form	NOUN
bptjm-33	79	9	with	with	ADP
bptjm-33	79	10	less	less	ADJ
bptjm-33	79	11	than	than	ADP
bptjm-33	79	12	40	40	NUM
bptjm-33	79	13	mutations	mutation	NOUN
bptjm-33	79	14	was	be	AUX
bptjm-33	79	15	identified	identify	VERB
bptjm-33	79	16	in	in	ADP
bptjm-33	79	17	the	the	DET
bptjm-33	79	18	psen2	psen2	NOUN
bptjm-33	79	19	gene	gene	NOUN
bptjm-33	79	20	,	,	PUNCT
bptjm-33	79	21	causing	cause	VERB
bptjm-33	79	22	an	an	DET
bptjm-33	79	23	increased	increased	ADJ
bptjm-33	79	24	level	level	NOUN
bptjm-33	79	25	of	of	ADP
bptjm-33	79	26	toxic	toxic	ADJ
bptjm-33	79	27	forms	form	NOUN
bptjm-33	79	28	of	of	ADP
bptjm-33	79	29	amyloid	amyloid	NOUN
bptjm-33	79	30	aβ42	aβ42	PROPN
bptjm-33	79	31	as	as	SCONJ
bptjm-33	79	32	opposed	oppose	VERB
bptjm-33	79	33	to	to	ADP
bptjm-33	79	34	non	non	ADJ
bptjm-33	79	35	-	-	ADJ
bptjm-33	79	36	toxic	toxic	ADJ
bptjm-33	79	37	aβ40	aβ40	PROPN
bptjm-33	79	38	,	,	PUNCT
bptjm-33	79	39	aggravating	aggravate	VERB
bptjm-33	79	40	ad	ad	NOUN
bptjm-33	79	41	pathology	pathology	NOUN
bptjm-33	79	42	.	.	PUNCT
bptjm-33	80	1	psen1	psen1	PROPN
bptjm-33	80	2	plays	play	VERB
bptjm-33	80	3	an	an	DET
bptjm-33	80	4	important	important	ADJ
bptjm-33	80	5	role	role	NOUN
bptjm-33	80	6	in	in	ADP
bptjm-33	80	7	the	the	DET
bptjm-33	80	8	production	production	NOUN
bptjm-33	80	9	of	of	ADP
bptjm-33	80	10	aβ	aβ	PRON
bptjm-33	80	11	from	from	ADP
bptjm-33	80	12	app	app	NOUN
bptjm-33	80	13	by	by	ADP
bptjm-33	80	14	activating	activate	VERB
bptjm-33	80	15	γ	γ	NOUN
bptjm-33	80	16	-	-	PUNCT
bptjm-33	80	17	secretase	secretase	NOUN
bptjm-33	80	18	.	.	PUNCT
bptjm-33	81	1	knockout	knockout	NOUN
bptjm-33	81	2	studies	study	NOUN
bptjm-33	81	3	of	of	ADP
bptjm-33	81	4	psen1	psen1	NOUN
bptjm-33	81	5	in	in	ADP
bptjm-33	81	6	mice	mice	NOUN
bptjm-33	81	7	models	model	NOUN
bptjm-33	81	8	showed	show	VERB
bptjm-33	81	9	synaptic	synaptic	ADJ
bptjm-33	81	10	dysfunction	dysfunction	NOUN
bptjm-33	81	11	and	and	CCONJ
bptjm-33	81	12	memory	memory	NOUN
bptjm-33	81	13	impairment	impairment	NOUN
bptjm-33	81	14	.	.	PUNCT
bptjm-33	82	1	on	on	ADP
bptjm-33	82	2	the	the	DET
bptjm-33	82	3	other	other	ADJ
bptjm-33	82	4	hand	hand	NOUN
bptjm-33	82	5	,	,	PUNCT
bptjm-33	82	6	psen-2	psen-2	NOUN
bptjm-33	82	7	mutations	mutation	NOUN
bptjm-33	82	8	might	might	AUX
bptjm-33	82	9	have	have	VERB
bptjm-33	82	10	a	a	DET
bptjm-33	82	11	critical	critical	ADJ
bptjm-33	82	12	effect	effect	NOUN
bptjm-33	82	13	on	on	ADP
bptjm-33	82	14	the	the	DET
bptjm-33	82	15	aβ	aβ	PROPN
bptjm-33	82	16	42/40	42/40	NUM
bptjm-33	82	17	ratio	ratio	NOUN
bptjm-33	82	18	,	,	PUNCT
bptjm-33	82	19	causing	cause	VERB
bptjm-33	82	20	familial	familial	ADJ
bptjm-33	82	21	ad	ad	NOUN
bptjm-33	82	22	in	in	ADP
bptjm-33	82	23	the	the	DET
bptjm-33	82	24	presence	presence	NOUN
bptjm-33	82	25	of	of	ADP
bptjm-33	82	26	normal	normal	ADJ
bptjm-33	82	27	psen-1	psen-1	NOUN
bptjm-33	82	28	alleles	allele	NOUN
bptjm-33	82	29	,	,	PUNCT
bptjm-33	82	30	but	but	CCONJ
bptjm-33	82	31	some	some	PRON
bptjm-33	82	32	of	of	ADP
bptjm-33	82	33	the	the	DET
bptjm-33	82	34	psen2	psen2	NOUN
bptjm-33	82	35	mutations	mutation	NOUN
bptjm-33	82	36	are	be	AUX
bptjm-33	82	37	rare	rare	ADJ
bptjm-33	82	38	polymorphisms	polymorphism	NOUN
bptjm-33	82	39	and	and	CCONJ
bptjm-33	82	40	are	be	AUX
bptjm-33	82	41	not	not	PART
bptjm-33	82	42	pathogenic	pathogenic	ADJ
bptjm-33	82	43	mutations	mutation	NOUN
bptjm-33	82	44	and	and	CCONJ
bptjm-33	82	45	plays	play	VERB
bptjm-33	82	46	a	a	DET
bptjm-33	82	47	relatively	relatively	ADV
bptjm-33	82	48	minor	minor	ADJ
bptjm-33	82	49	role	role	NOUN
bptjm-33	82	50	in	in	ADP
bptjm-33	82	51	aβ	aβ	ADP
bptjm-33	82	52	production15	production15	NOUN
bptjm-33	82	53	.	.	PUNCT
bptjm-33	83	1	3.3	3.3	NUM
bptjm-33	83	2	.	.	PUNCT
bptjm-33	84	1	apoe4	apoe4	ADJ
bptjm-33	84	2	apoe	apoe	ADJ
bptjm-33	84	3	protein	protein	NOUN
bptjm-33	84	4	is	be	AUX
bptjm-33	84	5	a	a	DET
bptjm-33	84	6	glycoprotein	glycoprotein	NOUN
bptjm-33	84	7	expressed	express	VERB
bptjm-33	84	8	highly	highly	ADV
bptjm-33	84	9	in	in	ADP
bptjm-33	84	10	the	the	DET
bptjm-33	84	11	liver	liver	NOUN
bptjm-33	84	12	and	and	CCONJ
bptjm-33	84	13	brain	brain	NOUN
bptjm-33	84	14	astrocytes	astrocyte	NOUN
bptjm-33	84	15	and	and	CCONJ
bptjm-33	84	16	some	some	DET
bptjm-33	84	17	microglia	microglia	NOUN
bptjm-33	84	18	.	.	PUNCT
bptjm-33	85	1	it	it	PRON
bptjm-33	85	2	serves	serve	VERB
bptjm-33	85	3	as	as	ADP
bptjm-33	85	4	a	a	DET
bptjm-33	85	5	receptor	receptor	NOUN
bptjm-33	85	6	-	-	PUNCT
bptjm-33	85	7	mediated	mediate	VERB
bptjm-33	85	8	endocytosis	endocytosis	NOUN
bptjm-33	85	9	ligand	ligand	NOUN
bptjm-33	85	10	for	for	ADP
bptjm-33	85	11	lipoprotein	lipoprotein	ADJ
bptjm-33	85	12	particles	particle	NOUN
bptjm-33	85	13	like	like	ADP
bptjm-33	85	14	cholesterol	cholesterol	NOUN
bptjm-33	85	15	,	,	PUNCT
bptjm-33	85	16	which	which	PRON
bptjm-33	85	17	is	be	AUX
bptjm-33	85	18	essential	essential	ADJ
bptjm-33	85	19	for	for	ADP
bptjm-33	85	20	myelin	myelin	NOUN
bptjm-33	85	21	production	production	NOUN
bptjm-33	85	22	and	and	CCONJ
bptjm-33	85	23	normal	normal	ADJ
bptjm-33	85	24	brain	brain	NOUN
bptjm-33	85	25	function	function	NOUN
bptjm-33	85	26	.	.	PUNCT
bptjm-33	86	1	the	the	DET
bptjm-33	86	2	apoe	apoe	ADJ
bptjm-33	86	3	gene	gene	NOUN
bptjm-33	86	4	located	locate	VERB
bptjm-33	86	5	on	on	ADP
bptjm-33	86	6	chromosome	chromosome	NOUN
bptjm-33	86	7	19	19	NUM
bptjm-33	86	8	has	have	VERB
bptjm-33	86	9	three	three	NUM
bptjm-33	86	10	isoforms	isoform	NOUN
bptjm-33	86	11	,	,	PUNCT
bptjm-33	86	12	apoe2	apoe2	PROPN
bptjm-33	86	13	,	,	PUNCT
bptjm-33	86	14	apoe3	apoe3	PROPN
bptjm-33	86	15	,	,	PUNCT
bptjm-33	86	16	and	and	CCONJ
bptjm-33	86	17	apoe4	apoe4	PROPN
bptjm-33	86	18	,	,	PUNCT
bptjm-33	86	19	which	which	PRON
bptjm-33	86	20	cause	cause	VERB
bptjm-33	86	21	changes	change	NOUN
bptjm-33	86	22	in	in	ADP
bptjm-33	86	23	the	the	DET
bptjm-33	86	24	coding	code	VERB
bptjm-33	86	25	sequence15	sequence15	NOUN
bptjm-33	86	26	.	.	PUNCT
bptjm-33	87	1	the	the	DET
bptjm-33	87	2	apoe4	apoe4	PROPN
bptjm-33	87	3	variant	variant	NOUN
bptjm-33	87	4	is	be	AUX
bptjm-33	87	5	the	the	DET
bptjm-33	87	6	most	most	ADV
bptjm-33	87	7	significant	significant	ADJ
bptjm-33	87	8	genetic	genetic	ADJ
bptjm-33	87	9	risk	risk	NOUN
bptjm-33	87	10	factor	factor	NOUN
bptjm-33	87	11	for	for	ADP
bptjm-33	87	12	sporadic	sporadic	ADJ
bptjm-33	87	13	alzheimer	alzheimer	PROPN
bptjm-33	87	14	’s	’s	PART
bptjm-33	87	15	disease	disease	NOUN
bptjm-33	87	16	(	(	PUNCT
bptjm-33	87	17	sad	sad	ADJ
bptjm-33	87	18	)	)	PUNCT
bptjm-33	87	19	.	.	PUNCT
bptjm-33	88	1	apoe4	apoe4	PROPN
bptjm-33	88	2	berkeley	berkeley	PROPN
bptjm-33	88	3	pharma	pharma	PROPN
bptjm-33	88	4	tech	tech	NOUN
bptjm-33	88	5	journal	journal	NOUN
bptjm-33	88	6	of	of	ADP
bptjm-33	88	7	medicine	medicine	NOUN
bptjm-33	88	8	|	|	ADV
bptjm-33	88	9	55	55	NUM
bptjm-33	88	10	has	have	VERB
bptjm-33	88	11	a	a	DET
bptjm-33	88	12	multidimensional	multidimensional	ADJ
bptjm-33	88	13	impact	impact	NOUN
bptjm-33	88	14	on	on	ADP
bptjm-33	88	15	the	the	DET
bptjm-33	88	16	pathogenesis	pathogenesis	NOUN
bptjm-33	88	17	of	of	ADP
bptjm-33	88	18	ad	ad	NOUN
bptjm-33	88	19	,	,	PUNCT
bptjm-33	88	20	including	include	VERB
bptjm-33	88	21	dysregulation	dysregulation	NOUN
bptjm-33	88	22	of	of	ADP
bptjm-33	88	23	lipids	lipid	NOUN
bptjm-33	88	24	and	and	CCONJ
bptjm-33	88	25	lipoproteins	lipoprotein	NOUN
bptjm-33	88	26	,	,	PUNCT
bptjm-33	88	27	such	such	ADJ
bptjm-33	88	28	as	as	ADP
bptjm-33	88	29	apoe	apoe	PROPN
bptjm-33	88	30	plasma	plasma	NOUN
bptjm-33	88	31	levels13	levels13	NOUN
bptjm-33	88	32	.	.	PUNCT
bptjm-33	89	1	the	the	DET
bptjm-33	89	2	apoeε4	apoeε4	PROPN
bptjm-33	89	3	allele	allele	PROPN
bptjm-33	89	4	is	be	AUX
bptjm-33	89	5	a	a	DET
bptjm-33	89	6	strong	strong	ADJ
bptjm-33	89	7	risk	risk	NOUN
bptjm-33	89	8	factor	factor	NOUN
bptjm-33	89	9	for	for	ADP
bptjm-33	89	10	both	both	DET
bptjm-33	89	11	early	early	ADJ
bptjm-33	89	12	onset	onset	VERB
bptjm-33	89	13	ad	ad	NOUN
bptjm-33	89	14	(	(	PUNCT
bptjm-33	89	15	eoad	eoad	NOUN
bptjm-33	89	16	)	)	PUNCT
bptjm-33	89	17	and	and	CCONJ
bptjm-33	89	18	late	late	ADJ
bptjm-33	89	19	onset	onset	NOUN
bptjm-33	89	20	ad	ad	NOUN
bptjm-33	89	21	(	(	PUNCT
bptjm-33	89	22	load	load	NOUN
bptjm-33	89	23	)	)	PUNCT
bptjm-33	89	24	compared	compare	VERB
bptjm-33	89	25	to	to	ADP
bptjm-33	89	26	apoeε2	apoeε2	NOUN
bptjm-33	89	27	and	and	CCONJ
bptjm-33	89	28	apoeε3	apoeε3	ADJ
bptjm-33	89	29	alleles	allele	NOUN
bptjm-33	89	30	,	,	PUNCT
bptjm-33	89	31	which	which	PRON
bptjm-33	89	32	are	be	AUX
bptjm-33	89	33	associated	associate	VERB
bptjm-33	89	34	with	with	ADP
bptjm-33	89	35	lower	low	ADJ
bptjm-33	89	36	risk	risk	NOUN
bptjm-33	89	37	and	and	CCONJ
bptjm-33	89	38	protective	protective	ADJ
bptjm-33	89	39	effect	effect	NOUN
bptjm-33	89	40	,	,	PUNCT
bptjm-33	89	41	respectively	respectively	ADV
bptjm-33	89	42	.	.	PUNCT
bptjm-33	90	1	apoeε4	apoeε4	PROPN
bptjm-33	90	2	plays	play	VERB
bptjm-33	90	3	an	an	DET
bptjm-33	90	4	important	important	ADJ
bptjm-33	90	5	role	role	NOUN
bptjm-33	90	6	in	in	ADP
bptjm-33	90	7	aβ	aβ	NOUN
bptjm-33	90	8	deposition	deposition	NOUN
bptjm-33	90	9	as	as	ADP
bptjm-33	90	10	a	a	DET
bptjm-33	90	11	senile	senile	ADJ
bptjm-33	90	12	plaque	plaque	NOUN
bptjm-33	90	13	and	and	CCONJ
bptjm-33	90	14	causes	cause	VERB
bptjm-33	90	15	cerebral	cerebral	ADJ
bptjm-33	90	16	amyloid	amyloid	NOUN
bptjm-33	90	17	angiopathy	angiopathy	ADJ
bptjm-33	90	18	(	(	PUNCT
bptjm-33	90	19	caa	caa	NOUN
bptjm-33	90	20	)	)	PUNCT
bptjm-33	90	21	,	,	PUNCT
bptjm-33	90	22	which	which	PRON
bptjm-33	90	23	is	be	AUX
bptjm-33	90	24	known	know	VERB
bptjm-33	90	25	as	as	ADP
bptjm-33	90	26	a	a	DET
bptjm-33	90	27	marker	marker	NOUN
bptjm-33	90	28	for	for	ADP
bptjm-33	90	29	ad	ad	NOUN
bptjm-33	90	30	.	.	PUNCT
bptjm-33	91	1	apoeε4	apoeε4	PROPN
bptjm-33	91	2	was	be	AUX
bptjm-33	91	3	also	also	ADV
bptjm-33	91	4	shown	show	VERB
bptjm-33	91	5	to	to	PART
bptjm-33	91	6	be	be	AUX
bptjm-33	91	7	associated	associate	VERB
bptjm-33	91	8	with	with	ADP
bptjm-33	91	9	vascular	vascular	ADJ
bptjm-33	91	10	damage	damage	NOUN
bptjm-33	91	11	in	in	ADP
bptjm-33	91	12	the	the	DET
bptjm-33	91	13	brain	brain	NOUN
bptjm-33	91	14	,	,	PUNCT
bptjm-33	91	15	which	which	PRON
bptjm-33	91	16	leads	lead	VERB
bptjm-33	91	17	to	to	ADP
bptjm-33	91	18	ad	ad	NOUN
bptjm-33	91	19	pathogenesis15	pathogenesis15	NOUN
bptjm-33	91	20	.	.	PUNCT
bptjm-33	92	1	3.4	3.4	NUM
bptjm-33	92	2	.	.	PUNCT
bptjm-33	92	3	clu	clu	PROPN
bptjm-33	92	4	and	and	CCONJ
bptjm-33	92	5	bin1	bin1	PROPN
bptjm-33	92	6	clusterin	clusterin	NOUN
bptjm-33	92	7	(	(	PUNCT
bptjm-33	92	8	clu	clu	NOUN
bptjm-33	92	9	)	)	PUNCT
bptjm-33	92	10	and	and	CCONJ
bptjm-33	92	11	bridging	bridge	VERB
bptjm-33	92	12	integrator	integrator	NOUN
bptjm-33	92	13	1	1	NUM
bptjm-33	92	14	(	(	PUNCT
bptjm-33	92	15	bin1	bin1	NOUN
bptjm-33	92	16	)	)	PUNCT
bptjm-33	92	17	genes	gene	NOUN
bptjm-33	92	18	are	be	AUX
bptjm-33	92	19	novel	novel	ADJ
bptjm-33	92	20	risk	risk	NOUN
bptjm-33	92	21	factors	factor	NOUN
bptjm-33	92	22	for	for	ADP
bptjm-33	92	23	load	load	NOUN
bptjm-33	92	24	.	.	PUNCT
bptjm-33	93	1	clu	clu	PROPN
bptjm-33	93	2	gene	gene	PROPN
bptjm-33	93	3	is	be	AUX
bptjm-33	93	4	reported	report	VERB
bptjm-33	93	5	to	to	PART
bptjm-33	93	6	be	be	AUX
bptjm-33	93	7	located	locate	VERB
bptjm-33	93	8	on	on	ADP
bptjm-33	93	9	chromosome	chromosome	NOUN
bptjm-33	93	10	8	8	NUM
bptjm-33	93	11	.	.	PUNCT
bptjm-33	94	1	under	under	ADP
bptjm-33	94	2	normal	normal	ADJ
bptjm-33	94	3	conditions	condition	NOUN
bptjm-33	94	4	,	,	PUNCT
bptjm-33	94	5	clu	clu	PROPN
bptjm-33	94	6	plays	play	VERB
bptjm-33	94	7	a	a	DET
bptjm-33	94	8	protective	protective	ADJ
bptjm-33	94	9	role	role	NOUN
bptjm-33	94	10	by	by	ADP
bptjm-33	94	11	interacting	interact	VERB
bptjm-33	94	12	with	with	ADP
bptjm-33	94	13	aβ	aβ	NOUN
bptjm-33	94	14	and	and	CCONJ
bptjm-33	94	15	promoting	promote	VERB
bptjm-33	94	16	its	its	PRON
bptjm-33	94	17	clearance	clearance	NOUN
bptjm-33	94	18	or	or	CCONJ
bptjm-33	94	19	a	a	DET
bptjm-33	94	20	neurotoxic	neurotoxic	ADJ
bptjm-33	94	21	role	role	NOUN
bptjm-33	94	22	by	by	ADP
bptjm-33	94	23	reducing	reduce	VERB
bptjm-33	94	24	aβ	aβ	NUM
bptjm-33	94	25	clearance	clearance	NOUN
bptjm-33	94	26	.	.	PUNCT
bptjm-33	95	1	however	however	ADV
bptjm-33	95	2	,	,	PUNCT
bptjm-33	95	3	in	in	ADP
bptjm-33	95	4	ad	ad	NOUN
bptjm-33	95	5	patients	patient	NOUN
bptjm-33	95	6	,	,	PUNCT
bptjm-33	95	7	clu	clu	PROPN
bptjm-33	95	8	is	be	AUX
bptjm-33	95	9	upregulated	upregulate	VERB
bptjm-33	95	10	in	in	ADP
bptjm-33	95	11	the	the	DET
bptjm-33	95	12	cortex	cortex	NOUN
bptjm-33	95	13	and	and	CCONJ
bptjm-33	95	14	hippocampus	hippocampus	NOUN
bptjm-33	95	15	.	.	PUNCT
bptjm-33	96	1	the	the	DET
bptjm-33	96	2	aβ	aβ	PROPN
bptjm-33	96	3	ratio	ratio	NOUN
bptjm-33	96	4	values	value	NOUN
bptjm-33	96	5	determine	determine	VERB
bptjm-33	96	6	whether	whether	SCONJ
bptjm-33	96	7	the	the	DET
bptjm-33	96	8	clu	clu	ADJ
bptjm-33	96	9	role	role	NOUN
bptjm-33	96	10	is	be	AUX
bptjm-33	96	11	neuroprotective	neuroprotective	ADJ
bptjm-33	96	12	or	or	CCONJ
bptjm-33	96	13	neurotoxic	neurotoxic	ADJ
bptjm-33	96	14	.	.	PUNCT
bptjm-33	97	1	bin1	bin1	PROPN
bptjm-33	97	2	is	be	AUX
bptjm-33	97	3	a	a	DET
bptjm-33	97	4	bin	bin	NOUN
bptjm-33	97	5	-	-	PUNCT
bptjm-33	97	6	amphiphysin	amphiphysin	NOUN
bptjm-33	97	7	-	-	PUNCT
bptjm-33	97	8	rvs	rvs	NOUN
bptjm-33	97	9	(	(	PUNCT
bptjm-33	97	10	bar	bar	NOUN
bptjm-33	97	11	)	)	PUNCT
bptjm-33	97	12	adaptor	adaptor	NOUN
bptjm-33	97	13	protein	protein	NOUN
bptjm-33	97	14	that	that	PRON
bptjm-33	97	15	is	be	AUX
bptjm-33	97	16	involved	involve	VERB
bptjm-33	97	17	in	in	ADP
bptjm-33	97	18	the	the	DET
bptjm-33	97	19	production	production	NOUN
bptjm-33	97	20	of	of	ADP
bptjm-33	97	21	membrane	membrane	NOUN
bptjm-33	97	22	curvature	curvature	NOUN
bptjm-33	97	23	and	and	CCONJ
bptjm-33	97	24	other	other	ADJ
bptjm-33	97	25	endocytosis	endocytosis	NOUN
bptjm-33	97	26	cellular	cellular	ADJ
bptjm-33	97	27	functions	function	NOUN
bptjm-33	97	28	.	.	PUNCT
bptjm-33	98	1	bin1	bin1	PROPN
bptjm-33	98	2	has	have	VERB
bptjm-33	98	3	several	several	ADJ
bptjm-33	98	4	isoforms	isoform	NOUN
bptjm-33	98	5	—	—	PUNCT
bptjm-33	98	6	some	some	PRON
bptjm-33	98	7	are	be	AUX
bptjm-33	98	8	found	find	VERB
bptjm-33	98	9	in	in	ADP
bptjm-33	98	10	the	the	DET
bptjm-33	98	11	brain	brain	NOUN
bptjm-33	98	12	,	,	PUNCT
bptjm-33	98	13	where	where	SCONJ
bptjm-33	98	14	they	they	PRON
bptjm-33	98	15	interact	interact	VERB
bptjm-33	98	16	with	with	ADP
bptjm-33	98	17	different	different	ADJ
bptjm-33	98	18	proteins	protein	NOUN
bptjm-33	98	19	such	such	ADJ
bptjm-33	98	20	as	as	ADP
bptjm-33	98	21	clathrin	clathrin	NOUN
bptjm-33	98	22	,	,	PUNCT
bptjm-33	98	23	synaptojanin	synaptojanin	VERB
bptjm-33	98	24	,	,	PUNCT
bptjm-33	98	25	and	and	CCONJ
bptjm-33	98	26	amphiphysin	amphiphysin	NOUN
bptjm-33	98	27	1	1	NUM
bptjm-33	98	28	,	,	PUNCT
bptjm-33	98	29	and	and	CCONJ
bptjm-33	98	30	others	other	NOUN
bptjm-33	98	31	in	in	ADP
bptjm-33	98	32	which	which	PRON
bptjm-33	98	33	they	they	PRON
bptjm-33	98	34	regulate	regulate	VERB
bptjm-33	98	35	synaptic	synaptic	ADJ
bptjm-33	98	36	vesicle	vesicle	NOUN
bptjm-33	98	37	endocytosis	endocytosis	NOUN
bptjm-33	98	38	.	.	PUNCT
bptjm-33	99	1	recently	recently	ADV
bptjm-33	99	2	,	,	PUNCT
bptjm-33	99	3	bin1	bin1	PROPN
bptjm-33	99	4	was	be	AUX
bptjm-33	99	5	recognized	recognize	VERB
bptjm-33	99	6	as	as	ADP
bptjm-33	99	7	the	the	DET
bptjm-33	99	8	second	second	ADJ
bptjm-33	99	9	most	most	ADV
bptjm-33	99	10	important	important	ADJ
bptjm-33	99	11	risk	risk	NOUN
bptjm-33	99	12	factor	factor	NOUN
bptjm-33	99	13	for	for	ADP
bptjm-33	99	14	load	load	NOUN
bptjm-33	99	15	after	after	ADP
bptjm-33	99	16	apoe	apoe	NOUN
bptjm-33	99	17	,	,	PUNCT
bptjm-33	99	18	where	where	SCONJ
bptjm-33	99	19	it	it	PRON
bptjm-33	99	20	plays	play	VERB
bptjm-33	99	21	a	a	DET
bptjm-33	99	22	role	role	NOUN
bptjm-33	99	23	in	in	ADP
bptjm-33	99	24	aβ	aβ	NOUN
bptjm-33	99	25	production	production	NOUN
bptjm-33	99	26	and	and	CCONJ
bptjm-33	99	27	as	as	ADP
bptjm-33	99	28	a	a	DET
bptjm-33	99	29	tau	tau	PROPN
bptjm-33	99	30	and	and	CCONJ
bptjm-33	99	31	nft	nft	PROPN
bptjm-33	99	32	pathology	pathology	PROPN
bptjm-33	99	33	modulator15	modulator15	PROPN
bptjm-33	99	34	.	.	PUNCT
bptjm-33	100	1	3.5	3.5	NUM
bptjm-33	100	2	.	.	PUNCT
bptjm-33	101	1	trem2	trem2	NOUN
bptjm-33	101	2	trem2	trem2	NOUN
bptjm-33	101	3	is	be	AUX
bptjm-33	101	4	a	a	DET
bptjm-33	101	5	transmembrane	transmembrane	ADJ
bptjm-33	101	6	receptor	receptor	NOUN
bptjm-33	101	7	expressed	express	VERB
bptjm-33	101	8	in	in	ADP
bptjm-33	101	9	cells	cell	NOUN
bptjm-33	101	10	of	of	ADP
bptjm-33	101	11	the	the	DET
bptjm-33	101	12	myeloid	myeloid	ADJ
bptjm-33	101	13	lineage	lineage	NOUN
bptjm-33	101	14	.	.	PUNCT
bptjm-33	102	1	it	it	PRON
bptjm-33	102	2	facilitates	facilitate	VERB
bptjm-33	102	3	mediating	mediate	VERB
bptjm-33	102	4	phagocytic	phagocytic	ADJ
bptjm-33	102	5	clearance	clearance	NOUN
bptjm-33	102	6	of	of	ADP
bptjm-33	102	7	neuronal	neuronal	ADJ
bptjm-33	102	8	debris	debris	NOUN
bptjm-33	102	9	and	and	CCONJ
bptjm-33	102	10	binds	bind	VERB
bptjm-33	102	11	anionic	anionic	ADJ
bptjm-33	102	12	carbohydrates	carbohydrate	NOUN
bptjm-33	102	13	,	,	PUNCT
bptjm-33	102	14	bacterial	bacterial	ADJ
bptjm-33	102	15	products	product	NOUN
bptjm-33	102	16	,	,	PUNCT
bptjm-33	102	17	and	and	CCONJ
bptjm-33	102	18	phospholipids	phospholipid	NOUN
bptjm-33	102	19	to	to	PART
bptjm-33	102	20	transmit	transmit	VERB
bptjm-33	102	21	intracellular	intracellular	ADJ
bptjm-33	102	22	signals	signal	NOUN
bptjm-33	102	23	through	through	ADP
bptjm-33	102	24	the	the	DET
bptjm-33	102	25	associated	associated	ADJ
bptjm-33	102	26	transmembrane	transmembrane	NOUN
bptjm-33	102	27	adaptor	adaptor	NOUN
bptjm-33	102	28	dap1255	dap1255	NOUN
bptjm-33	102	29	and	and	CCONJ
bptjm-33	102	30	further	further	ADJ
bptjm-33	102	31	phosphorylation	phosphorylation	NOUN
bptjm-33	102	32	of	of	ADP
bptjm-33	102	33	downstream	downstream	ADJ
bptjm-33	102	34	mediators	mediator	NOUN
bptjm-33	102	35	.	.	PUNCT
bptjm-33	103	1	in	in	ADP
bptjm-33	103	2	ad	ad	NOUN
bptjm-33	103	3	,	,	PUNCT
bptjm-33	103	4	a	a	DET
bptjm-33	103	5	rare	rare	ADJ
bptjm-33	103	6	mutation	mutation	NOUN
bptjm-33	103	7	of	of	ADP
bptjm-33	103	8	trem2	trem2	NOUN
bptjm-33	103	9	(	(	PUNCT
bptjm-33	103	10	r47h	r47h	NOUN
bptjm-33	103	11	)	)	PUNCT
bptjm-33	103	12	has	have	AUX
bptjm-33	103	13	been	be	AUX
bptjm-33	103	14	reported	report	VERB
bptjm-33	103	15	that	that	PRON
bptjm-33	103	16	plays	play	VERB
bptjm-33	103	17	a	a	DET
bptjm-33	103	18	potent	potent	ADJ
bptjm-33	103	19	role	role	NOUN
bptjm-33	103	20	in	in	ADP
bptjm-33	103	21	aggravating	aggravate	VERB
bptjm-33	103	22	the	the	DET
bptjm-33	103	23	risk	risk	NOUN
bptjm-33	103	24	of	of	ADP
bptjm-33	103	25	developing	develop	VERB
bptjm-33	103	26	ad	ad	NOUN
bptjm-33	103	27	.	.	PUNCT
bptjm-33	104	1	this	this	DET
bptjm-33	104	2	mutation	mutation	NOUN
bptjm-33	104	3	leads	lead	VERB
bptjm-33	104	4	to	to	ADP
bptjm-33	104	5	an	an	DET
bptjm-33	104	6	inability	inability	NOUN
bptjm-33	104	7	of	of	ADP
bptjm-33	104	8	the	the	DET
bptjm-33	104	9	receptors	receptor	NOUN
bptjm-33	104	10	to	to	PART
bptjm-33	104	11	clear	clear	VERB
bptjm-33	104	12	aβ	aβ	PRON
bptjm-33	104	13	from	from	ADP
bptjm-33	104	14	the	the	DET
bptjm-33	104	15	cns	cns	NOUN
bptjm-33	104	16	,	,	PUNCT
bptjm-33	104	17	contributing	contribute	VERB
bptjm-33	104	18	to	to	ADP
bptjm-33	104	19	aβ	aβ	NOUN
bptjm-33	104	20	accumulation	accumulation	NOUN
bptjm-33	104	21	and	and	CCONJ
bptjm-33	104	22	further	further	ADJ
bptjm-33	104	23	intensification	intensification	NOUN
bptjm-33	104	24	of	of	ADP
bptjm-33	104	25	pathogenesis	pathogenesis	NOUN
bptjm-33	104	26	in	in	ADP
bptjm-33	104	27	ad	ad	NOUN
bptjm-33	104	28	patients16	patients16	NOUN
bptjm-33	104	29	.	.	PUNCT
bptjm-33	105	1	berkeley	berkeley	PROPN
bptjm-33	105	2	pharma	pharma	PROPN
bptjm-33	105	3	tech	tech	PROPN
bptjm-33	105	4	journal	journal	NOUN
bptjm-33	105	5	of	of	ADP
bptjm-33	105	6	medicine	medicine	NOUN
bptjm-33	105	7	|	|	ADV
bptjm-33	105	8	56	56	NUM
bptjm-33	105	9	4	4	NUM
bptjm-33	105	10	.	.	PUNCT
bptjm-33	106	1	mirna	mirna	NOUN
bptjm-33	106	2	usage	usage	NOUN
bptjm-33	106	3	in	in	ADP
bptjm-33	106	4	the	the	DET
bptjm-33	106	5	treatment	treatment	NOUN
bptjm-33	106	6	of	of	ADP
bptjm-33	106	7	ad	ad	NOUN
bptjm-33	106	8	as	as	ADP
bptjm-33	106	9	a	a	DET
bptjm-33	106	10	result	result	NOUN
bptjm-33	106	11	of	of	ADP
bptjm-33	106	12	their	their	PRON
bptjm-33	106	13	ability	ability	NOUN
bptjm-33	106	14	to	to	PART
bptjm-33	106	15	post	post	VERB
bptjm-33	106	16	-	-	ADJ
bptjm-33	106	17	transcriptionally	transcriptionally	ADV
bptjm-33	106	18	regulate	regulate	VERB
bptjm-33	106	19	many	many	ADJ
bptjm-33	106	20	of	of	ADP
bptjm-33	106	21	the	the	DET
bptjm-33	106	22	genes	gene	NOUN
bptjm-33	106	23	involved	involve	VERB
bptjm-33	106	24	in	in	ADP
bptjm-33	106	25	ad	ad	NOUN
bptjm-33	106	26	,	,	PUNCT
bptjm-33	106	27	mirnas	mirna	NOUN
bptjm-33	106	28	have	have	AUX
bptjm-33	106	29	emerged	emerge	VERB
bptjm-33	106	30	as	as	ADP
bptjm-33	106	31	a	a	DET
bptjm-33	106	32	valuable	valuable	ADJ
bptjm-33	106	33	potential	potential	ADJ
bptjm-33	106	34	therapeutic	therapeutic	ADJ
bptjm-33	106	35	agent	agent	NOUN
bptjm-33	106	36	for	for	ADP
bptjm-33	106	37	the	the	DET
bptjm-33	106	38	treatment	treatment	NOUN
bptjm-33	106	39	of	of	ADP
bptjm-33	106	40	ad	ad	NOUN
bptjm-33	106	41	.	.	PUNCT
bptjm-33	107	1	various	various	ADJ
bptjm-33	107	2	mirnas	mirna	NOUN
bptjm-33	107	3	have	have	AUX
bptjm-33	107	4	been	be	AUX
bptjm-33	107	5	shown	show	VERB
bptjm-33	107	6	to	to	PART
bptjm-33	107	7	be	be	AUX
bptjm-33	107	8	integral	integral	ADJ
bptjm-33	107	9	to	to	ADP
bptjm-33	107	10	the	the	DET
bptjm-33	107	11	production	production	NOUN
bptjm-33	107	12	and	and	CCONJ
bptjm-33	107	13	regulation	regulation	NOUN
bptjm-33	107	14	of	of	ADP
bptjm-33	107	15	amyloid	amyloid	NOUN
bptjm-33	107	16	-	-	PUNCT
bptjm-33	107	17	beta	beta	NOUN
bptjm-33	107	18	,	,	PUNCT
bptjm-33	107	19	and	and	CCONJ
bptjm-33	107	20	thus	thus	ADV
bptjm-33	107	21	modification	modification	NOUN
bptjm-33	107	22	of	of	ADP
bptjm-33	107	23	mirna	mirna	NOUN
bptjm-33	107	24	expression	expression	NOUN
bptjm-33	107	25	levels	level	NOUN
bptjm-33	107	26	could	could	AUX
bptjm-33	107	27	attenuate	attenuate	VERB
bptjm-33	107	28	facets	facet	NOUN
bptjm-33	107	29	of	of	ADP
bptjm-33	107	30	ad	ad	NOUN
bptjm-33	107	31	pathology16	pathology16	NOUN
bptjm-33	107	32	.	.	PUNCT
bptjm-33	108	1	therapeutic	therapeutic	ADJ
bptjm-33	108	2	approaches	approach	NOUN
bptjm-33	108	3	to	to	ADP
bptjm-33	108	4	ad	ad	NOUN
bptjm-33	108	5	utilizing	utilize	VERB
bptjm-33	108	6	mirnas	mirna	NOUN
bptjm-33	108	7	generally	generally	ADV
bptjm-33	108	8	function	function	VERB
bptjm-33	108	9	through	through	ADP
bptjm-33	108	10	two	two	NUM
bptjm-33	108	11	pathways	pathway	NOUN
bptjm-33	108	12	.	.	PUNCT
bptjm-33	109	1	mirnas	mirna	NOUN
bptjm-33	109	2	expression	expression	NOUN
bptjm-33	109	3	levels	level	NOUN
bptjm-33	109	4	may	may	AUX
bptjm-33	109	5	be	be	AUX
bptjm-33	109	6	restored	restore	VERB
bptjm-33	109	7	to	to	ADP
bptjm-33	109	8	their	their	PRON
bptjm-33	109	9	normal	normal	ADJ
bptjm-33	109	10	baseline	baseline	NOUN
bptjm-33	109	11	magnitude	magnitude	NOUN
bptjm-33	109	12	or	or	CCONJ
bptjm-33	109	13	be	be	AUX
bptjm-33	109	14	upregulated	upregulate	VERB
bptjm-33	109	15	through	through	ADP
bptjm-33	109	16	the	the	DET
bptjm-33	109	17	in	in	ADP
bptjm-33	109	18	vivo	vivo	ADJ
bptjm-33	109	19	transfection	transfection	NOUN
bptjm-33	109	20	of	of	ADP
bptjm-33	109	21	mirna	mirna	PROPN
bptjm-33	109	22	oligonucleotide	oligonucleotide	NOUN
bptjm-33	109	23	that	that	PRON
bptjm-33	109	24	mimics	mimic	VERB
bptjm-33	109	25	endogenous	endogenous	ADJ
bptjm-33	109	26	mirna	mirna	NOUN
bptjm-33	109	27	functions	function	NOUN
bptjm-33	109	28	.	.	PUNCT
bptjm-33	110	1	alternatively	alternatively	ADV
bptjm-33	110	2	,	,	PUNCT
bptjm-33	110	3	harmful	harmful	ADJ
bptjm-33	110	4	mirnas	mirna	NOUN
bptjm-33	110	5	in	in	ADP
bptjm-33	110	6	ad	ad	NOUN
bptjm-33	110	7	can	can	AUX
bptjm-33	110	8	be	be	AUX
bptjm-33	110	9	downregulated	downregulate	VERB
bptjm-33	110	10	through	through	ADP
bptjm-33	110	11	the	the	DET
bptjm-33	110	12	administration	administration	NOUN
bptjm-33	110	13	of	of	ADP
bptjm-33	110	14	complementary	complementary	ADJ
bptjm-33	110	15	antisense	antisense	NOUN
bptjm-33	110	16	oligonucleotides17	oligonucleotides17	X
bptjm-33	110	17	.	.	PUNCT
bptjm-33	111	1	subsequently	subsequently	ADV
bptjm-33	111	2	,	,	PUNCT
bptjm-33	111	3	the	the	DET
bptjm-33	111	4	most	most	ADV
bptjm-33	111	5	recent	recent	ADJ
bptjm-33	111	6	studies	study	NOUN
bptjm-33	111	7	in	in	ADP
bptjm-33	111	8	the	the	DET
bptjm-33	111	9	field	field	NOUN
bptjm-33	111	10	have	have	AUX
bptjm-33	111	11	demonstrated	demonstrate	VERB
bptjm-33	111	12	promising	promising	ADJ
bptjm-33	111	13	results	result	NOUN
bptjm-33	111	14	of	of	ADP
bptjm-33	111	15	mirnas	mirna	NOUN
bptjm-33	111	16	facilitating	facilitate	VERB
bptjm-33	111	17	neuroprotectant	neuroprotectant	ADJ
bptjm-33	111	18	and	and	CCONJ
bptjm-33	111	19	ameliorating	ameliorate	VERB
bptjm-33	111	20	cognitive	cognitive	ADJ
bptjm-33	111	21	deficits	deficit	NOUN
bptjm-33	111	22	through	through	ADP
bptjm-33	111	23	investigations	investigation	NOUN
bptjm-33	111	24	using	use	VERB
bptjm-33	111	25	in	in	ADP
bptjm-33	111	26	vivo	vivo	ADJ
bptjm-33	111	27	ad	ad	NOUN
bptjm-33	111	28	animal	animal	NOUN
bptjm-33	111	29	models	model	NOUN
bptjm-33	111	30	and	and	CCONJ
bptjm-33	111	31	in	in	ADP
bptjm-33	111	32	vitro	vitro	X
bptjm-33	111	33	cell	cell	NOUN
bptjm-33	111	34	cultures17	cultures17	NOUN
bptjm-33	111	35	.	.	PUNCT
bptjm-33	112	1	in	in	ADP
bptjm-33	112	2	one	one	NUM
bptjm-33	112	3	study	study	NOUN
bptjm-33	112	4	,	,	PUNCT
bptjm-33	112	5	upregulation	upregulation	NOUN
bptjm-33	112	6	of	of	ADP
bptjm-33	112	7	the	the	DET
bptjm-33	112	8	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	112	9	molecule	molecule	NOUN
bptjm-33	112	10	via	via	ADP
bptjm-33	112	11	in	in	ADP
bptjm-33	112	12	vitro	vitro	X
bptjm-33	112	13	transfection	transfection	NOUN
bptjm-33	112	14	reduced	reduce	VERB
bptjm-33	112	15	hyperphosphorylated	hyperphosphorylated	ADJ
bptjm-33	112	16	tau	tau	PROPN
bptjm-33	112	17	clusters	cluster	NOUN
bptjm-33	112	18	and	and	CCONJ
bptjm-33	112	19	inhibited	inhibited	ADJ
bptjm-33	112	20	levels	level	NOUN
bptjm-33	112	21	of	of	ADP
bptjm-33	112	22	neuronal	neuronal	ADJ
bptjm-33	112	23	apoptosis	apoptosis	NOUN
bptjm-33	112	24	in	in	ADP
bptjm-33	112	25	swedish	swedish	ADJ
bptjm-33	112	26	mutant	mutant	ADJ
bptjm-33	112	27	amyloidprecursor	amyloidprecursor	NOUN
bptjm-33	112	28	protein	protein	NOUN
bptjm-33	112	29	(	(	PUNCT
bptjm-33	112	30	appswe	appswe	NOUN
bptjm-33	112	31	)	)	PUNCT
bptjm-33	112	32	cells	cell	NOUN
bptjm-33	112	33	via	via	ADP
bptjm-33	112	34	inhibiting	inhibit	VERB
bptjm-33	112	35	the	the	DET
bptjm-33	112	36	upstream	upstream	ADJ
bptjm-33	112	37	expression	expression	NOUN
bptjm-33	112	38	of	of	ADP
bptjm-33	112	39	glycogen	glycogen	NOUN
bptjm-33	112	40	synthase	synthase	NOUN
bptjm-33	112	41	kinase-3	kinase-3	PROPN
bptjm-33	112	42	(	(	PUNCT
bptjm-33	112	43	gsk-3	gsk-3	NOUN
bptjm-33	112	44	)	)	PUNCT
bptjm-33	112	45	apoptotic	apoptotic	ADJ
bptjm-33	112	46	pathway18	pathway18	NOUN
bptjm-33	112	47	.	.	PUNCT
bptjm-33	113	1	this	this	PRON
bptjm-33	113	2	is	be	AUX
bptjm-33	113	3	significant	significant	ADJ
bptjm-33	113	4	since	since	SCONJ
bptjm-33	113	5	mir-23	mir-23	NOUN
bptjm-33	113	6	-	-	PUNCT
bptjm-33	113	7	b-3p	b-3p	NOUN
bptjm-33	113	8	has	have	VERB
bptjm-33	113	9	clinical	clinical	ADJ
bptjm-33	113	10	diagnostic	diagnostic	ADJ
bptjm-33	113	11	potential	potential	NOUN
bptjm-33	113	12	due	due	ADP
bptjm-33	113	13	to	to	ADP
bptjm-33	113	14	it	it	PRON
bptjm-33	113	15	being	be	AUX
bptjm-33	113	16	greatly	greatly	ADV
bptjm-33	113	17	downregulated	downregulate	VERB
bptjm-33	113	18	in	in	ADP
bptjm-33	113	19	the	the	DET
bptjm-33	113	20	blood	blood	NOUN
bptjm-33	113	21	plasma	plasma	NOUN
bptjm-33	113	22	of	of	ADP
bptjm-33	113	23	ad	ad	NOUN
bptjm-33	113	24	patients	patient	NOUN
bptjm-33	113	25	when	when	SCONJ
bptjm-33	113	26	compared	compare	VERB
bptjm-33	113	27	to	to	ADP
bptjm-33	113	28	healthy	healthy	ADJ
bptjm-33	113	29	controls	control	NOUN
bptjm-33	113	30	,	,	PUNCT
bptjm-33	113	31	and	and	CCONJ
bptjm-33	113	32	further	further	ADJ
bptjm-33	113	33	investigations	investigation	NOUN
bptjm-33	113	34	revealed	reveal	VERB
bptjm-33	113	35	a	a	DET
bptjm-33	113	36	positive	positive	ADJ
bptjm-33	113	37	correlation	correlation	NOUN
bptjm-33	113	38	between	between	ADP
bptjm-33	113	39	increased	increase	VERB
bptjm-33	113	40	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	113	41	and	and	CCONJ
bptjm-33	113	42	improved	improved	ADJ
bptjm-33	113	43	measures	measure	NOUN
bptjm-33	113	44	of	of	ADP
bptjm-33	113	45	cognitive	cognitive	ADJ
bptjm-33	113	46	function	function	NOUN
bptjm-33	113	47	for	for	ADP
bptjm-33	113	48	individuals	individual	NOUN
bptjm-33	113	49	with	with	ADP
bptjm-33	113	50	ad18	ad18	PROPN
bptjm-33	113	51	.	.	PUNCT
bptjm-33	114	1	the	the	DET
bptjm-33	114	2	mirna-200	mirna-200	PROPN
bptjm-33	114	3	family	family	NOUN
bptjm-33	114	4	has	have	AUX
bptjm-33	114	5	also	also	ADV
bptjm-33	114	6	been	be	AUX
bptjm-33	114	7	shown	show	VERB
bptjm-33	114	8	to	to	PART
bptjm-33	114	9	play	play	VERB
bptjm-33	114	10	an	an	DET
bptjm-33	114	11	innate	innate	ADJ
bptjm-33	114	12	defensive	defensive	ADJ
bptjm-33	114	13	role	role	NOUN
bptjm-33	114	14	against	against	ADP
bptjm-33	114	15	aβ	aβ	ADV
bptjm-33	114	16	-	-	PUNCT
bptjm-33	114	17	induced	induce	VERB
bptjm-33	114	18	neurotoxicity	neurotoxicity	NOUN
bptjm-33	114	19	.	.	PUNCT
bptjm-33	115	1	a	a	DET
bptjm-33	115	2	study	study	NOUN
bptjm-33	115	3	conducted	conduct	VERB
bptjm-33	115	4	by	by	ADP
bptjm-33	115	5	higaki	higaki	PROPN
bptjm-33	115	6	et	et	PROPN
bptjm-33	115	7	.	.	PUNCT
bptjm-33	116	1	al	al	PROPN
bptjm-33	116	2	.	.	PROPN
bptjm-33	116	3	demonstrated	demonstrate	VERB
bptjm-33	116	4	that	that	DET
bptjm-33	116	5	administration	administration	NOUN
bptjm-33	116	6	of	of	ADP
bptjm-33	116	7	members	member	NOUN
bptjm-33	116	8	of	of	ADP
bptjm-33	116	9	the	the	DET
bptjm-33	116	10	mirna-200	mirna-200	ADJ
bptjm-33	116	11	family	family	NOUN
bptjm-33	116	12	–	–	PUNCT
bptjm-33	116	13	such	such	ADJ
bptjm-33	116	14	as	as	ADP
bptjm-33	116	15	mir-200b	mir-200b	PROPN
bptjm-33	116	16	/	/	SYM
bptjm-33	116	17	c	c	NOUN
bptjm-33	116	18	–	–	PUNCT
bptjm-33	116	19	showcased	showcase	VERB
bptjm-33	116	20	reduced	reduce	VERB
bptjm-33	116	21	aβ	aβ	ADP
bptjm-33	116	22	in	in	ADP
bptjm-33	116	23	cellular	cellular	ADJ
bptjm-33	116	24	mediums	medium	NOUN
bptjm-33	116	25	and	and	CCONJ
bptjm-33	116	26	in	in	ADP
bptjm-33	116	27	vivo	vivo	ADJ
bptjm-33	116	28	amelioration	amelioration	NOUN
bptjm-33	116	29	of	of	ADP
bptjm-33	116	30	aβ	aβ	ADV
bptjm-33	116	31	-	-	PUNCT
bptjm-33	116	32	induced	induce	VERB
bptjm-33	116	33	cognitive	cognitive	ADJ
bptjm-33	116	34	impairments	impairment	NOUN
bptjm-33	116	35	in	in	ADP
bptjm-33	116	36	tg2576	tg2576	PROPN
bptjm-33	116	37	mouse	mouse	NOUN
bptjm-33	116	38	models	model	NOUN
bptjm-33	116	39	,	,	PUNCT
bptjm-33	116	40	thus	thus	ADV
bptjm-33	116	41	leading	lead	VERB
bptjm-33	116	42	to	to	ADP
bptjm-33	116	43	restoration	restoration	NOUN
bptjm-33	116	44	of	of	ADP
bptjm-33	116	45	spatial	spatial	ADJ
bptjm-33	116	46	memory	memory	NOUN
bptjm-33	116	47	performance	performance	NOUN
bptjm-33	116	48	in	in	ADP
bptjm-33	116	49	the	the	DET
bptjm-33	116	50	barnes	barnes	PROPN
bptjm-33	116	51	maze	maze	PROPN
bptjm-33	116	52	test19	test19	PROPN
bptjm-33	116	53	.	.	PUNCT
bptjm-33	117	1	aβ	aβ	PRON
bptjm-33	117	2	has	have	AUX
bptjm-33	117	3	been	be	AUX
bptjm-33	117	4	shown	show	VERB
bptjm-33	117	5	to	to	PART
bptjm-33	117	6	degrade	degrade	VERB
bptjm-33	117	7	the	the	DET
bptjm-33	117	8	neuronal	neuronal	ADJ
bptjm-33	117	9	memory	memory	NOUN
bptjm-33	117	10	centers	center	NOUN
bptjm-33	117	11	and	and	CCONJ
bptjm-33	117	12	synapses	synapsis	NOUN
bptjm-33	117	13	that	that	PRON
bptjm-33	117	14	act	act	VERB
bptjm-33	117	15	upon	upon	SCONJ
bptjm-33	117	16	the	the	DET
bptjm-33	117	17	hippocampus	hippocampus	NOUN
bptjm-33	117	18	and	and	CCONJ
bptjm-33	117	19	frontal	frontal	ADJ
bptjm-33	117	20	cortex	cortex	NOUN
bptjm-33	117	21	tissue	tissue	NOUN
bptjm-33	117	22	,	,	PUNCT
bptjm-33	117	23	making	make	VERB
bptjm-33	117	24	the	the	DET
bptjm-33	117	25	mir-200	mir-200	PROPN
bptjm-33	117	26	family	family	NOUN
bptjm-33	117	27	a	a	DET
bptjm-33	117	28	potential	potential	ADJ
bptjm-33	117	29	therapeutic	therapeutic	ADJ
bptjm-33	117	30	target	target	NOUN
bptjm-33	117	31	due	due	ADP
bptjm-33	117	32	to	to	ADP
bptjm-33	117	33	their	their	PRON
bptjm-33	117	34	berkeley	berkeley	PROPN
bptjm-33	117	35	pharma	pharma	PROPN
bptjm-33	117	36	tech	tech	NOUN
bptjm-33	117	37	journal	journal	NOUN
bptjm-33	117	38	of	of	ADP
bptjm-33	117	39	medicine	medicine	NOUN
bptjm-33	117	40	|	|	ADV
bptjm-33	117	41	57	57	NUM
bptjm-33	117	42	ability	ability	NOUN
bptjm-33	117	43	to	to	PART
bptjm-33	117	44	alter	alter	VERB
bptjm-33	117	45	s6k1	s6k1	NOUN
bptjm-33	117	46	levels	level	NOUN
bptjm-33	117	47	and	and	CCONJ
bptjm-33	117	48	modulate	modulate	VERB
bptjm-33	117	49	extracellular	extracellular	ADJ
bptjm-33	117	50	insulin	insulin	NOUN
bptjm-33	117	51	signaling	signal	VERB
bptjm-33	117	52	in	in	ADP
bptjm-33	117	53	the	the	DET
bptjm-33	117	54	brain19	brain19	NOUN
bptjm-33	117	55	.	.	PUNCT
bptjm-33	118	1	similarly	similarly	ADV
bptjm-33	118	2	,	,	PUNCT
bptjm-33	118	3	another	another	DET
bptjm-33	118	4	study	study	NOUN
bptjm-33	118	5	conducted	conduct	VERB
bptjm-33	118	6	by	by	ADP
bptjm-33	118	7	an	an	DET
bptjm-33	118	8	et	et	NOUN
bptjm-33	118	9	.	.	PUNCT
bptjm-33	119	1	al	al	PROPN
bptjm-33	119	2	demonstrated	demonstrate	VERB
bptjm-33	119	3	the	the	DET
bptjm-33	119	4	differential	differential	ADJ
bptjm-33	119	5	expression	expression	NOUN
bptjm-33	119	6	of	of	ADP
bptjm-33	119	7	mir-124	mir-124	NOUN
bptjm-33	119	8	in	in	ADP
bptjm-33	119	9	ad	ad	NOUN
bptjm-33	119	10	compared	compare	VERB
bptjm-33	119	11	to	to	ADP
bptjm-33	119	12	healthy	healthy	ADJ
bptjm-33	119	13	control	control	PROPN
bptjm-33	119	14	populations17	populations17	PROPN
bptjm-33	119	15	.	.	PUNCT
bptjm-33	120	1	mir-124	mir-124	PROPN
bptjm-33	120	2	was	be	AUX
bptjm-33	120	3	revealed	reveal	VERB
bptjm-33	120	4	to	to	PART
bptjm-33	120	5	interact	interact	VERB
bptjm-33	120	6	with	with	ADP
bptjm-33	120	7	the	the	DET
bptjm-33	120	8	beta	beta	NOUN
bptjm-33	120	9	-	-	PUNCT
bptjm-33	120	10	site	site	NOUN
bptjm-33	120	11	amyloid	amyloid	NOUN
bptjm-33	120	12	precursor	precursor	NOUN
bptjm-33	120	13	protein	protein	NOUN
bptjm-33	120	14	cleaving	cleave	VERB
bptjm-33	120	15	enzyme	enzyme	NOUN
bptjm-33	120	16	1	1	NUM
bptjm-33	120	17	(	(	PUNCT
bptjm-33	120	18	bace1	bace1	NOUN
bptjm-33	120	19	)	)	PUNCT
bptjm-33	120	20	network	network	NOUN
bptjm-33	120	21	in	in	ADP
bptjm-33	120	22	ad	ad	NOUN
bptjm-33	120	23	,	,	PUNCT
bptjm-33	120	24	which	which	PRON
bptjm-33	120	25	is	be	AUX
bptjm-33	120	26	prominently	prominently	ADV
bptjm-33	120	27	involved	involve	VERB
bptjm-33	120	28	in	in	ADP
bptjm-33	120	29	ad	ad	NOUN
bptjm-33	120	30	via	via	ADP
bptjm-33	120	31	functioning	function	VERB
bptjm-33	120	32	in	in	ADP
bptjm-33	120	33	the	the	DET
bptjm-33	120	34	production	production	NOUN
bptjm-33	120	35	of	of	ADP
bptjm-33	120	36	aβ	aβ	PRON
bptjm-33	120	37	from	from	ADP
bptjm-33	120	38	app20	app20	NOUN
bptjm-33	120	39	.	.	PUNCT
bptjm-33	121	1	it	it	PRON
bptjm-33	121	2	was	be	AUX
bptjm-33	121	3	found	find	VERB
bptjm-33	121	4	that	that	SCONJ
bptjm-33	121	5	mir-124	mir-124	NOUN
bptjm-33	121	6	expression	expression	NOUN
bptjm-33	121	7	was	be	AUX
bptjm-33	121	8	downregulated	downregulate	VERB
bptjm-33	121	9	in	in	ADP
bptjm-33	121	10	ad	ad	NOUN
bptjm-33	121	11	models	model	NOUN
bptjm-33	121	12	while	while	SCONJ
bptjm-33	121	13	bace1	bace1	NOUN
bptjm-33	121	14	was	be	AUX
bptjm-33	121	15	simultaneously	simultaneously	ADV
bptjm-33	121	16	overexpressed20	overexpressed20	NOUN
bptjm-33	121	17	.	.	PUNCT
bptjm-33	122	1	subsequently	subsequently	ADV
bptjm-33	122	2	,	,	PUNCT
bptjm-33	122	3	mir-124	mir-124	PROPN
bptjm-33	122	4	is	be	AUX
bptjm-33	122	5	a	a	DET
bptjm-33	122	6	potential	potential	ADJ
bptjm-33	122	7	novel	novel	ADJ
bptjm-33	122	8	therapeutic	therapeutic	ADJ
bptjm-33	122	9	target	target	NOUN
bptjm-33	122	10	as	as	ADP
bptjm-33	122	11	its	its	PRON
bptjm-33	122	12	administration	administration	NOUN
bptjm-33	122	13	via	via	ADP
bptjm-33	122	14	transfected	transfecte	VERB
bptjm-33	122	15	mimics	mimic	NOUN
bptjm-33	122	16	could	could	AUX
bptjm-33	122	17	be	be	AUX
bptjm-33	122	18	utilized	utilize	VERB
bptjm-33	122	19	to	to	PART
bptjm-33	122	20	regulate	regulate	VERB
bptjm-33	122	21	and	and	CCONJ
bptjm-33	122	22	inhibit	inhibit	VERB
bptjm-33	122	23	expression	expression	NOUN
bptjm-33	122	24	of	of	ADP
bptjm-33	122	25	bace1	bace1	NOUN
bptjm-33	122	26	mrnas	mrna	NOUN
bptjm-33	122	27	and	and	CCONJ
bptjm-33	122	28	proteins	protein	NOUN
bptjm-33	122	29	in	in	ADP
bptjm-33	122	30	affected	affect	VERB
bptjm-33	122	31	ad	ad	NOUN
bptjm-33	122	32	tissues	tissue	NOUN
bptjm-33	122	33	,	,	PUNCT
bptjm-33	122	34	resulting	result	VERB
bptjm-33	122	35	in	in	ADP
bptjm-33	122	36	lowered	lower	VERB
bptjm-33	122	37	aβ	aβ	NOUN
bptjm-33	122	38	and	and	CCONJ
bptjm-33	122	39	nft	nft	PROPN
bptjm-33	122	40	burden20	burden20	NOUN
bptjm-33	122	41	.	.	PUNCT
bptjm-33	123	1	many	many	ADJ
bptjm-33	123	2	other	other	ADJ
bptjm-33	123	3	mirnas	mirna	NOUN
bptjm-33	123	4	are	be	AUX
bptjm-33	123	5	upregulated	upregulate	VERB
bptjm-33	123	6	in	in	ADP
bptjm-33	123	7	ad	ad	NOUN
bptjm-33	123	8	pathogenesis	pathogenesis	NOUN
bptjm-33	123	9	and	and	CCONJ
bptjm-33	123	10	contribute	contribute	VERB
bptjm-33	123	11	to	to	ADP
bptjm-33	123	12	neurotoxicity	neurotoxicity	NOUN
bptjm-33	123	13	,	,	PUNCT
bptjm-33	123	14	and	and	CCONJ
bptjm-33	123	15	thus	thus	ADV
bptjm-33	123	16	therapeutic	therapeutic	ADJ
bptjm-33	123	17	approaches	approach	NOUN
bptjm-33	123	18	that	that	PRON
bptjm-33	123	19	leverage	leverage	NOUN
bptjm-33	123	20	underexpressing	underexpresse	VERB
bptjm-33	123	21	these	these	DET
bptjm-33	123	22	classes	class	NOUN
bptjm-33	123	23	of	of	ADP
bptjm-33	123	24	mirnas	mirna	NOUN
bptjm-33	123	25	could	could	AUX
bptjm-33	123	26	potentially	potentially	ADV
bptjm-33	123	27	alleviate	alleviate	VERB
bptjm-33	123	28	the	the	DET
bptjm-33	123	29	negative	negative	ADJ
bptjm-33	123	30	effects	effect	NOUN
bptjm-33	123	31	on	on	ADP
bptjm-33	123	32	neurons	neuron	NOUN
bptjm-33	123	33	posed	pose	VERB
bptjm-33	123	34	by	by	ADP
bptjm-33	123	35	ad	ad	NOUN
bptjm-33	123	36	.	.	PUNCT
bptjm-33	124	1	through	through	ADP
bptjm-33	124	2	an	an	DET
bptjm-33	124	3	analysis	analysis	NOUN
bptjm-33	124	4	study	study	NOUN
bptjm-33	124	5	on	on	ADP
bptjm-33	124	6	sh	sh	PROPN
bptjm-33	124	7	-	-	PUNCT
bptjm-33	124	8	sy5y	sy5y	PROPN
bptjm-33	124	9	cell	cell	NOUN
bptjm-33	124	10	cultures	culture	NOUN
bptjm-33	124	11	,	,	PUNCT
bptjm-33	124	12	it	it	PRON
bptjm-33	124	13	was	be	AUX
bptjm-33	124	14	shown	show	VERB
bptjm-33	124	15	that	that	SCONJ
bptjm-33	124	16	the	the	DET
bptjm-33	124	17	pathogenesis	pathogenesis	NOUN
bptjm-33	124	18	of	of	ADP
bptjm-33	124	19	ad	ad	NOUN
bptjm-33	124	20	triggers	trigger	NOUN
bptjm-33	124	21	dysregulation	dysregulation	NOUN
bptjm-33	124	22	of	of	ADP
bptjm-33	124	23	mirna-146a	mirna-146a	PROPN
bptjm-33	124	24	,	,	PUNCT
bptjm-33	124	25	causing	cause	VERB
bptjm-33	124	26	significant	significant	ADJ
bptjm-33	124	27	overexpression	overexpression	NOUN
bptjm-33	124	28	of	of	ADP
bptjm-33	124	29	these	these	DET
bptjm-33	124	30	mirnas	mirna	NOUN
bptjm-33	124	31	in	in	ADP
bptjm-33	124	32	the	the	DET
bptjm-33	124	33	brain	brain	NOUN
bptjm-33	124	34	that	that	PRON
bptjm-33	124	35	results	result	VERB
bptjm-33	124	36	in	in	ADP
bptjm-33	124	37	the	the	DET
bptjm-33	124	38	disruption	disruption	NOUN
bptjm-33	124	39	of	of	ADP
bptjm-33	124	40	the	the	DET
bptjm-33	124	41	phosphatase	phosphatase	NOUN
bptjm-33	124	42	pten	pten	NOUN
bptjm-33	124	43	,	,	PUNCT
bptjm-33	124	44	thus	thus	ADV
bptjm-33	124	45	causing	cause	VERB
bptjm-33	124	46	increased	increase	VERB
bptjm-33	124	47	hyperphosphorylation	hyperphosphorylation	NOUN
bptjm-33	124	48	of	of	ADP
bptjm-33	124	49	tau	tau	PROPN
bptjm-33	124	50	protein	protein	NOUN
bptjm-33	124	51	and	and	CCONJ
bptjm-33	124	52	nft	nft	PROPN
bptjm-33	124	53	cluster	cluster	NOUN
bptjm-33	124	54	formation21	formation21	PROPN
bptjm-33	124	55	.	.	PUNCT
bptjm-33	125	1	the	the	DET
bptjm-33	125	2	effects	effect	NOUN
bptjm-33	125	3	of	of	ADP
bptjm-33	125	4	mirna-146a	mirna-146a	PROPN
bptjm-33	125	5	overexpression	overexpression	NOUN
bptjm-33	125	6	were	be	AUX
bptjm-33	125	7	most	most	ADV
bptjm-33	125	8	pronounced	pronounce	VERB
bptjm-33	125	9	in	in	ADP
bptjm-33	125	10	the	the	DET
bptjm-33	125	11	brain	brain	NOUN
bptjm-33	125	12	regions	region	NOUN
bptjm-33	125	13	that	that	PRON
bptjm-33	125	14	are	be	AUX
bptjm-33	125	15	generally	generally	ADV
bptjm-33	125	16	most	most	ADV
bptjm-33	125	17	susceptible	susceptible	ADJ
bptjm-33	125	18	to	to	ADP
bptjm-33	125	19	tau	tau	PROPN
bptjm-33	125	20	aggregation	aggregation	NOUN
bptjm-33	125	21	in	in	ADP
bptjm-33	125	22	ad	ad	NOUN
bptjm-33	125	23	and	and	CCONJ
bptjm-33	125	24	other	other	ADJ
bptjm-33	125	25	related	relate	VERB
bptjm-33	125	26	dementias	dementia	NOUN
bptjm-33	125	27	–	–	PUNCT
bptjm-33	125	28	most	most	ADV
bptjm-33	125	29	notably	notably	ADV
bptjm-33	125	30	in	in	ADP
bptjm-33	125	31	the	the	DET
bptjm-33	125	32	hippocampus	hippocampus	NOUN
bptjm-33	125	33	and	and	CCONJ
bptjm-33	125	34	temporal	temporal	ADJ
bptjm-33	125	35	cortices	cortex	NOUN
bptjm-33	125	36	,	,	PUNCT
bptjm-33	125	37	which	which	PRON
bptjm-33	125	38	are	be	AUX
bptjm-33	125	39	fundamental	fundamental	ADJ
bptjm-33	125	40	to	to	ADP
bptjm-33	125	41	learning	learning	NOUN
bptjm-33	125	42	and	and	CCONJ
bptjm-33	125	43	memory	memory	NOUN
bptjm-33	125	44	formation21	formation21	NOUN
bptjm-33	125	45	.	.	PUNCT
bptjm-33	126	1	in	in	ADP
bptjm-33	126	2	this	this	DET
bptjm-33	126	3	same	same	ADJ
bptjm-33	126	4	study	study	NOUN
bptjm-33	126	5	,	,	PUNCT
bptjm-33	126	6	the	the	DET
bptjm-33	126	7	5xfad	5xfad	NUM
bptjm-33	126	8	transgenic	transgenic	NOUN
bptjm-33	126	9	mice	mouse	NOUN
bptjm-33	126	10	model	model	NOUN
bptjm-33	126	11	reacted	react	VERB
bptjm-33	126	12	positively	positively	ADV
bptjm-33	126	13	to	to	ADP
bptjm-33	126	14	the	the	DET
bptjm-33	126	15	downregulation	downregulation	NOUN
bptjm-33	126	16	of	of	ADP
bptjm-33	126	17	mirna-146a	mirna-146a	PROPN
bptjm-33	126	18	via	via	ADP
bptjm-33	126	19	a	a	DET
bptjm-33	126	20	series	series	NOUN
bptjm-33	126	21	of	of	ADP
bptjm-33	126	22	mirna-146a	mirna-146a	PROPN
bptjm-33	126	23	antagomir	antagomir	NOUN
bptjm-33	126	24	injections	injection	NOUN
bptjm-33	126	25	,	,	PUNCT
bptjm-33	126	26	ultimately	ultimately	ADV
bptjm-33	126	27	showing	show	VERB
bptjm-33	126	28	a	a	DET
bptjm-33	126	29	restoration	restoration	NOUN
bptjm-33	126	30	of	of	ADP
bptjm-33	126	31	endogenous	endogenous	ADJ
bptjm-33	126	32	frequencies	frequency	NOUN
bptjm-33	126	33	of	of	ADP
bptjm-33	126	34	phosphatase	phosphatase	NOUN
bptjm-33	126	35	pten	pten	NOUN
bptjm-33	126	36	and	and	CCONJ
bptjm-33	126	37	a	a	DET
bptjm-33	126	38	rescue	rescue	NOUN
bptjm-33	126	39	of	of	ADP
bptjm-33	126	40	function	function	NOUN
bptjm-33	126	41	in	in	ADP
bptjm-33	126	42	hippocampal	hippocampal	ADJ
bptjm-33	126	43	memory	memory	NOUN
bptjm-33	126	44	and	and	CCONJ
bptjm-33	126	45	neural	neural	ADJ
bptjm-33	126	46	pathways21	pathways21	NOUN
bptjm-33	126	47	.	.	PUNCT
bptjm-33	127	1	while	while	SCONJ
bptjm-33	127	2	mirnas	mirna	NOUN
bptjm-33	127	3	have	have	AUX
bptjm-33	127	4	traditionally	traditionally	ADV
bptjm-33	127	5	been	be	AUX
bptjm-33	127	6	downregulated	downregulate	VERB
bptjm-33	127	7	in	in	ADP
bptjm-33	127	8	ad	ad	NOUN
bptjm-33	127	9	pathology	pathology	NOUN
bptjm-33	127	10	,	,	PUNCT
bptjm-33	127	11	the	the	DET
bptjm-33	127	12	overexpression	overexpression	NOUN
bptjm-33	127	13	of	of	ADP
bptjm-33	127	14	mir-146a	mir-146a	NOUN
bptjm-33	127	15	has	have	AUX
bptjm-33	127	16	been	be	AUX
bptjm-33	127	17	experimentally	experimentally	ADV
bptjm-33	127	18	shown	show	VERB
bptjm-33	127	19	to	to	PART
bptjm-33	127	20	be	be	AUX
bptjm-33	127	21	intricately	intricately	ADV
bptjm-33	127	22	involved	involve	VERB
bptjm-33	127	23	in	in	ADP
bptjm-33	127	24	the	the	DET
bptjm-33	127	25	tau	tau	PROPN
bptjm-33	127	26	pathology	pathology	NOUN
bptjm-33	127	27	of	of	ADP
bptjm-33	127	28	ad	ad	NOUN
bptjm-33	127	29	,	,	PUNCT
bptjm-33	127	30	thus	thus	ADV
bptjm-33	127	31	making	make	VERB
bptjm-33	127	32	the	the	DET
bptjm-33	127	33	selective	selective	ADJ
bptjm-33	127	34	inhibition	inhibition	NOUN
bptjm-33	127	35	of	of	ADP
bptjm-33	127	36	this	this	DET
bptjm-33	127	37	mirna	mirna	NOUN
bptjm-33	127	38	molecule	molecule	NOUN
bptjm-33	127	39	a	a	DET
bptjm-33	127	40	viable	viable	ADJ
bptjm-33	127	41	target	target	NOUN
bptjm-33	127	42	for	for	ADP
bptjm-33	127	43	an	an	DET
bptjm-33	127	44	in	in	ADP
bptjm-33	127	45	vivo	vivo	NOUN
bptjm-33	127	46	therapeutic	therapeutic	ADJ
bptjm-33	127	47	of	of	ADP
bptjm-33	127	48	the	the	DET
bptjm-33	127	49	disease	disease	NOUN
bptjm-33	127	50	.	.	PUNCT
bptjm-33	128	1	a	a	DET
bptjm-33	128	2	more	more	ADV
bptjm-33	128	3	extensive	extensive	ADJ
bptjm-33	128	4	list	list	NOUN
bptjm-33	128	5	of	of	ADP
bptjm-33	128	6	identified	identify	VERB
bptjm-33	128	7	mirnas	mirna	NOUN
bptjm-33	128	8	and	and	CCONJ
bptjm-33	128	9	their	their	PRON
bptjm-33	128	10	pathophysiologic	pathophysiologic	ADJ
bptjm-33	128	11	targets	target	NOUN
bptjm-33	128	12	in	in	ADP
bptjm-33	128	13	ad	ad	NOUN
bptjm-33	128	14	are	be	AUX
bptjm-33	128	15	displayed	display	VERB
bptjm-33	128	16	below	below	ADP
bptjm-33	128	17	in	in	ADP
bptjm-33	128	18	table	table	NOUN
bptjm-33	128	19	1	1	NUM
bptjm-33	128	20	.	.	PUNCT
bptjm-33	128	21	berkeley	berkeley	PROPN
bptjm-33	128	22	pharma	pharma	PROPN
bptjm-33	128	23	tech	tech	PROPN
bptjm-33	128	24	journal	journal	NOUN
bptjm-33	128	25	of	of	ADP
bptjm-33	128	26	medicine	medicine	NOUN
bptjm-33	128	27	|	|	ADV
bptjm-33	128	28	58	58	NUM
bptjm-33	128	29	the	the	DET
bptjm-33	128	30	clinical	clinical	ADJ
bptjm-33	128	31	application	application	NOUN
bptjm-33	128	32	of	of	ADP
bptjm-33	128	33	mirna	mirna	NOUN
bptjm-33	128	34	in	in	ADP
bptjm-33	128	35	ad	ad	NOUN
bptjm-33	128	36	can	can	AUX
bptjm-33	128	37	be	be	AUX
bptjm-33	128	38	achieved	achieve	VERB
bptjm-33	128	39	through	through	ADP
bptjm-33	128	40	diverse	diverse	ADJ
bptjm-33	128	41	pathways	pathway	NOUN
bptjm-33	128	42	and	and	CCONJ
bptjm-33	128	43	delivery	delivery	NOUN
bptjm-33	128	44	methods	method	NOUN
bptjm-33	128	45	.	.	PUNCT
bptjm-33	129	1	studies	study	NOUN
bptjm-33	129	2	have	have	AUX
bptjm-33	129	3	shown	show	VERB
bptjm-33	129	4	that	that	SCONJ
bptjm-33	129	5	naturally	naturally	ADV
bptjm-33	129	6	occurring	occur	VERB
bptjm-33	129	7	compounds	compound	NOUN
bptjm-33	129	8	like	like	ADP
bptjm-33	129	9	resveratrol	resveratrol	NOUN
bptjm-33	129	10	can	can	AUX
bptjm-33	129	11	act	act	VERB
bptjm-33	129	12	upon	upon	SCONJ
bptjm-33	129	13	and	and	CCONJ
bptjm-33	129	14	regulate	regulate	VERB
bptjm-33	129	15	specific	specific	ADJ
bptjm-33	129	16	mirnas	mirna	NOUN
bptjm-33	129	17	in	in	ADP
bptjm-33	129	18	the	the	DET
bptjm-33	129	19	body	body	NOUN
bptjm-33	129	20	and	and	CCONJ
bptjm-33	129	21	,	,	PUNCT
bptjm-33	129	22	therefore	therefore	ADV
bptjm-33	129	23	,	,	PUNCT
bptjm-33	129	24	can	can	AUX
bptjm-33	129	25	be	be	AUX
bptjm-33	129	26	attuned	attune	VERB
bptjm-33	129	27	to	to	PART
bptjm-33	129	28	modulate	modulate	VERB
bptjm-33	129	29	mirna	mirna	NOUN
bptjm-33	129	30	expression	expression	NOUN
bptjm-33	129	31	levels	level	NOUN
bptjm-33	129	32	in	in	ADP
bptjm-33	129	33	vivo22	vivo22	NOUN
bptjm-33	129	34	.	.	PUNCT
bptjm-33	130	1	conversely	conversely	ADV
bptjm-33	130	2	,	,	PUNCT
bptjm-33	130	3	certain	certain	ADJ
bptjm-33	130	4	anti	anti	ADJ
bptjm-33	130	5	-	-	ADJ
bptjm-33	130	6	inflammatory	inflammatory	ADJ
bptjm-33	130	7	therapeutics	therapeutic	NOUN
bptjm-33	130	8	can	can	AUX
bptjm-33	130	9	exhibit	exhibit	VERB
bptjm-33	130	10	regulatory	regulatory	ADJ
bptjm-33	130	11	-	-	PUNCT
bptjm-33	130	12	like	like	ADJ
bptjm-33	130	13	control	control	NOUN
bptjm-33	130	14	on	on	ADP
bptjm-33	130	15	the	the	DET
bptjm-33	130	16	expression	expression	NOUN
bptjm-33	130	17	of	of	ADP
bptjm-33	130	18	certain	certain	ADJ
bptjm-33	130	19	mirna	mirna	NOUN
bptjm-33	130	20	molecules	molecule	NOUN
bptjm-33	130	21	,	,	PUNCT
bptjm-33	130	22	thus	thus	ADV
bptjm-33	130	23	providing	provide	VERB
bptjm-33	130	24	a	a	DET
bptjm-33	130	25	treatment	treatment	NOUN
bptjm-33	130	26	option	option	NOUN
bptjm-33	130	27	for	for	ADP
bptjm-33	130	28	ad	ad	NOUN
bptjm-33	130	29	that	that	PRON
bptjm-33	130	30	functions	function	NOUN
bptjm-33	130	31	via	via	ADP
bptjm-33	130	32	mirna	mirna	PROPN
bptjm-33	130	33	modulation23	modulation23	PROPN
bptjm-33	130	34	.	.	PUNCT
bptjm-33	131	1	other	other	ADJ
bptjm-33	131	2	innovative	innovative	ADJ
bptjm-33	131	3	and	and	CCONJ
bptjm-33	131	4	emerging	emerge	VERB
bptjm-33	131	5	approaches	approach	NOUN
bptjm-33	131	6	involve	involve	VERB
bptjm-33	131	7	using	use	VERB
bptjm-33	131	8	exosome	exosome	ADJ
bptjm-33	131	9	vesicles	vesicle	NOUN
bptjm-33	131	10	as	as	ADP
bptjm-33	131	11	a	a	DET
bptjm-33	131	12	targeted	target	VERB
bptjm-33	131	13	vehicle	vehicle	NOUN
bptjm-33	131	14	to	to	PART
bptjm-33	131	15	effectively	effectively	ADV
bptjm-33	131	16	cross	cross	VERB
bptjm-33	131	17	the	the	DET
bptjm-33	131	18	bloodbrain	bloodbrain	NOUN
bptjm-33	131	19	barrier	barrier	NOUN
bptjm-33	131	20	and	and	CCONJ
bptjm-33	131	21	deliver	deliver	VERB
bptjm-33	131	22	mirna	mirna	NOUN
bptjm-33	131	23	into	into	ADP
bptjm-33	131	24	localized	localized	ADJ
bptjm-33	131	25	regions	region	NOUN
bptjm-33	131	26	for	for	ADP
bptjm-33	131	27	the	the	DET
bptjm-33	131	28	greatest	great	ADJ
bptjm-33	131	29	benefit	benefit	NOUN
bptjm-33	131	30	in	in	ADP
bptjm-33	131	31	the	the	DET
bptjm-33	131	32	diseased	diseased	ADJ
bptjm-33	131	33	brain23	brain23	NOUN
bptjm-33	131	34	.	.	PUNCT
bptjm-33	132	1	mirna	mirna	PROPN
bptjm-33	132	2	target	target	PROPN
bptjm-33	132	3	/	/	SYM
bptjm-33	132	4	pathologic	pathologic	ADJ
bptjm-33	132	5	process	process	NOUN
bptjm-33	132	6	mir-126	mir-126	NOUN
bptjm-33	132	7	involved	involve	VERB
bptjm-33	132	8	in	in	ADP
bptjm-33	132	9	bace1	bace1	NOUN
bptjm-33	132	10	expression	expression	NOUN
bptjm-33	132	11	;	;	PUNCT
bptjm-33	132	12	overexpression	overexpression	NOUN
bptjm-33	132	13	suppresses	suppress	VERB
bptjm-33	132	14	bace1	bace1	NOUN
bptjm-33	133	1	while	while	SCONJ
bptjm-33	133	2	under	under	ADP
bptjm-33	133	3	expression	expression	NOUN
bptjm-33	133	4	increases	increase	VERB
bptjm-33	133	5	bace1	bace1	NOUN
bptjm-33	133	6	proliferation	proliferation	NOUN
bptjm-33	133	7	mir-146	mir-146	NOUN
bptjm-33	133	8	observed	observe	VERB
bptjm-33	133	9	to	to	PART
bptjm-33	133	10	have	have	VERB
bptjm-33	133	11	higher	high	ADJ
bptjm-33	133	12	levels	level	NOUN
bptjm-33	133	13	of	of	ADP
bptjm-33	133	14	expression	expression	NOUN
bptjm-33	133	15	in	in	ADP
bptjm-33	133	16	mci	mci	PROPN
bptjm-33	133	17	patients	patient	NOUN
bptjm-33	133	18	that	that	PRON
bptjm-33	133	19	later	later	ADV
bptjm-33	133	20	manifested	manifest	VERB
bptjm-33	133	21	with	with	ADP
bptjm-33	133	22	ad	ad	NOUN
bptjm-33	133	23	;	;	PUNCT
bptjm-33	133	24	is	be	AUX
bptjm-33	133	25	also	also	ADV
bptjm-33	133	26	associated	associate	VERB
bptjm-33	133	27	with	with	ADP
bptjm-33	133	28	apoe4	apoe4	ADJ
bptjm-33	133	29	protein	protein	NOUN
bptjm-33	133	30	expression	expression	NOUN
bptjm-33	133	31	mir-26b	mir-26b	NOUN
bptjm-33	133	32	shown	show	VERB
bptjm-33	133	33	to	to	PART
bptjm-33	133	34	increase	increase	VERB
bptjm-33	133	35	tau	tau	PROPN
bptjm-33	133	36	phosphorylation	phosphorylation	NOUN
bptjm-33	133	37	and	and	CCONJ
bptjm-33	133	38	neuronal	neuronal	ADJ
bptjm-33	133	39	apoptosis	apoptosis	NOUN
bptjm-33	133	40	mir-181a	mir-181a	NOUN
bptjm-33	133	41	associated	associate	VERB
bptjm-33	133	42	with	with	ADP
bptjm-33	133	43	an	an	DET
bptjm-33	133	44	increased	increase	VERB
bptjm-33	133	45	aβ	aβ	NOUN
bptjm-33	133	46	concentration	concentration	NOUN
bptjm-33	133	47	in	in	ADP
bptjm-33	133	48	cerebrospinal	cerebrospinal	ADJ
bptjm-33	133	49	fluid	fluid	NOUN
bptjm-33	133	50	mir-200b	mir-200b	NOUN
bptjm-33	133	51	under	under	ADP
bptjm-33	133	52	expressed	express	VERB
bptjm-33	133	53	in	in	ADP
bptjm-33	133	54	experiments	experiment	NOUN
bptjm-33	133	55	with	with	ADP
bptjm-33	133	56	app	app	PROPN
bptjm-33	133	57	/	/	SYM
bptjm-33	133	58	ps1	ps1	NOUN
bptjm-33	133	59	transgenic	transgenic	NOUN
bptjm-33	133	60	mice	mouse	NOUN
bptjm-33	133	61	&	&	CCONJ
bptjm-33	133	62	positively	positively	ADV
bptjm-33	133	63	reduced	reduce	VERB
bptjm-33	133	64	app	app	NOUN
bptjm-33	133	65	expression	expression	NOUN
bptjm-33	133	66	mir-339	mir-339	NOUN
bptjm-33	133	67	-	-	PUNCT
bptjm-33	133	68	5p	5p	NUM
bptjm-33	133	69	targets	target	NOUN
bptjm-33	133	70	&	&	CCONJ
bptjm-33	133	71	inhibits	inhibit	VERB
bptjm-33	133	72	bace1	bace1	NOUN
bptjm-33	133	73	;	;	PUNCT
bptjm-33	133	74	expression	expression	NOUN
bptjm-33	133	75	levels	level	NOUN
bptjm-33	133	76	were	be	AUX
bptjm-33	133	77	shown	show	VERB
bptjm-33	133	78	to	to	PART
bptjm-33	133	79	be	be	AUX
bptjm-33	133	80	reduced	reduce	VERB
bptjm-33	133	81	in	in	ADP
bptjm-33	133	82	ad	ad	NOUN
bptjm-33	133	83	patients	patient	NOUN
bptjm-33	133	84	mir-16	mir-16	PROPN
bptjm-33	133	85	-	-	PUNCT
bptjm-33	133	86	5p	5p	PROPN
bptjm-33	133	87	&	&	CCONJ
bptjm-33	133	88	mir-708	mir-708	NOUN
bptjm-33	133	89	-	-	PUNCT
bptjm-33	133	90	5p	5p	NOUN
bptjm-33	133	91	differentially	differentially	ADV
bptjm-33	133	92	expressed	express	VERB
bptjm-33	133	93	molecule	molecule	NOUN
bptjm-33	133	94	in	in	ADP
bptjm-33	133	95	the	the	DET
bptjm-33	133	96	cerebrospinal	cerebrospinal	ADJ
bptjm-33	133	97	fluid	fluid	ADJ
bptjm-33	133	98	cells	cell	NOUN
bptjm-33	133	99	of	of	ADP
bptjm-33	133	100	ad	ad	NOUN
bptjm-33	133	101	patients	patient	NOUN
bptjm-33	133	102	;	;	PUNCT
bptjm-33	133	103	potential	potential	ADJ
bptjm-33	133	104	biomarker	biomarker	NOUN
bptjm-33	133	105	berkeley	berkeley	PROPN
bptjm-33	133	106	pharma	pharma	PROPN
bptjm-33	133	107	tech	tech	NOUN
bptjm-33	133	108	journal	journal	NOUN
bptjm-33	133	109	of	of	ADP
bptjm-33	133	110	medicine	medicine	NOUN
bptjm-33	133	111	|	|	ADV
bptjm-33	133	112	59	59	NUM
bptjm-33	133	113	mir-93	mir-93	NOUN
bptjm-33	133	114	-	-	PUNCT
bptjm-33	133	115	5p	5p	NOUN
bptjm-33	133	116	differentially	differentially	ADV
bptjm-33	133	117	expressed	express	VERB
bptjm-33	133	118	molecule	molecule	NOUN
bptjm-33	133	119	in	in	ADP
bptjm-33	133	120	the	the	DET
bptjm-33	133	121	cerebrospinal	cerebrospinal	ADJ
bptjm-33	133	122	fluid	fluid	ADJ
bptjm-33	133	123	cells	cell	NOUN
bptjm-33	133	124	of	of	ADP
bptjm-33	133	125	ad	ad	NOUN
bptjm-33	133	126	patients	patient	NOUN
bptjm-33	133	127	;	;	PUNCT
bptjm-33	133	128	potential	potential	ADJ
bptjm-33	133	129	biomarker	biomarker	NOUN
bptjm-33	133	130	table	table	NOUN
bptjm-33	133	131	1	1	NUM
bptjm-33	133	132	:	:	PUNCT
bptjm-33	133	133	list	list	NOUN
bptjm-33	133	134	of	of	ADP
bptjm-33	133	135	the	the	DET
bptjm-33	133	136	relevant	relevant	ADJ
bptjm-33	133	137	mirnas	mirna	NOUN
bptjm-33	133	138	&	&	CCONJ
bptjm-33	133	139	the	the	DET
bptjm-33	133	140	corresponding	corresponding	ADJ
bptjm-33	133	141	nervous	nervous	ADJ
bptjm-33	133	142	system	system	NOUN
bptjm-33	133	143	targets	target	VERB
bptjm-33	133	144	5	5	NUM
bptjm-33	133	145	.	.	PUNCT
bptjm-33	133	146	mirnas	mirna	NOUN
bptjm-33	133	147	functioning	function	VERB
bptjm-33	133	148	as	as	ADP
bptjm-33	133	149	predictive	predictive	ADJ
bptjm-33	133	150	biomarkers	biomarker	NOUN
bptjm-33	133	151	of	of	ADP
bptjm-33	133	152	ad	ad	NOUN
bptjm-33	133	153	5.1	5.1	NUM
bptjm-33	133	154	.	.	PUNCT
bptjm-33	134	1	amyloid	amyloid	NOUN
bptjm-33	134	2	cascade	cascade	NOUN
bptjm-33	134	3	hypothesis	hypothesis	NOUN
bptjm-33	134	4	there	there	PRON
bptjm-33	134	5	is	be	VERB
bptjm-33	134	6	evidence	evidence	NOUN
bptjm-33	134	7	that	that	SCONJ
bptjm-33	134	8	aβ	aβ	PROPN
bptjm-33	134	9	and	and	CCONJ
bptjm-33	134	10	its	its	PRON
bptjm-33	134	11	imbalance	imbalance	NOUN
bptjm-33	134	12	between	between	ADP
bptjm-33	134	13	production	production	NOUN
bptjm-33	134	14	and	and	CCONJ
bptjm-33	134	15	destruction	destruction	NOUN
bptjm-33	134	16	is	be	AUX
bptjm-33	134	17	a	a	DET
bptjm-33	134	18	leading	lead	VERB
bptjm-33	134	19	cause	cause	NOUN
bptjm-33	134	20	of	of	ADP
bptjm-33	134	21	ad	ad	NOUN
bptjm-33	134	22	,	,	PUNCT
bptjm-33	134	23	as	as	SCONJ
bptjm-33	134	24	it	it	PRON
bptjm-33	134	25	causes	cause	VERB
bptjm-33	134	26	a	a	DET
bptjm-33	134	27	cascade	cascade	NOUN
bptjm-33	134	28	of	of	ADP
bptjm-33	134	29	events	event	NOUN
bptjm-33	134	30	in	in	ADP
bptjm-33	134	31	the	the	DET
bptjm-33	134	32	bodily	bodily	ADJ
bptjm-33	134	33	systems24,25	systems24,25	PROPN
bptjm-33	134	34	.	.	PUNCT
bptjm-33	135	1	app	app	PROPN
bptjm-33	135	2	is	be	AUX
bptjm-33	135	3	cleaved	cleave	VERB
bptjm-33	135	4	by	by	ADP
bptjm-33	135	5	the	the	DET
bptjm-33	135	6	bace-1	bace-1	PROPN
bptjm-33	135	7	gene	gene	NOUN
bptjm-33	135	8	first	first	ADV
bptjm-33	135	9	to	to	PART
bptjm-33	135	10	produce	produce	VERB
bptjm-33	135	11	the	the	DET
bptjm-33	135	12	aβ	aβ	PROPN
bptjm-33	135	13	protein25	protein25	NOUN
bptjm-33	135	14	,	,	PUNCT
bptjm-33	135	15	26	26	NUM
bptjm-33	135	16	.	.	PUNCT
bptjm-33	136	1	some	some	DET
bptjm-33	136	2	proteases	protease	NOUN
bptjm-33	136	3	are	be	AUX
bptjm-33	136	4	meant	mean	VERB
bptjm-33	136	5	to	to	PART
bptjm-33	136	6	clear	clear	VERB
bptjm-33	136	7	the	the	DET
bptjm-33	136	8	aβ	aβ	NOUN
bptjm-33	136	9	in	in	ADP
bptjm-33	136	10	the	the	DET
bptjm-33	136	11	system	system	NOUN
bptjm-33	136	12	through	through	ADP
bptjm-33	136	13	proteolytic	proteolytic	ADJ
bptjm-33	136	14	degradation	degradation	NOUN
bptjm-33	136	15	and	and	CCONJ
bptjm-33	136	16	receptor	receptor	NOUN
bptjm-33	136	17	-	-	PUNCT
bptjm-33	136	18	modulated	modulate	VERB
bptjm-33	136	19	endocytosis24	endocytosis24	NOUN
bptjm-33	136	20	.	.	PUNCT
bptjm-33	137	1	when	when	SCONJ
bptjm-33	137	2	this	this	DET
bptjm-33	137	3	process	process	NOUN
bptjm-33	137	4	is	be	AUX
bptjm-33	137	5	not	not	PART
bptjm-33	137	6	done	do	VERB
bptjm-33	137	7	at	at	ADP
bptjm-33	137	8	an	an	DET
bptjm-33	137	9	adequate	adequate	ADJ
bptjm-33	137	10	rate	rate	NOUN
bptjm-33	137	11	,	,	PUNCT
bptjm-33	137	12	the	the	DET
bptjm-33	137	13	aβ	aβ	NOUN
bptjm-33	137	14	protein	protein	NOUN
bptjm-33	137	15	can	can	AUX
bptjm-33	137	16	build	build	VERB
bptjm-33	137	17	up	up	ADP
bptjm-33	137	18	in	in	ADP
bptjm-33	137	19	the	the	DET
bptjm-33	137	20	blood	blood	NOUN
bptjm-33	137	21	plasma	plasma	NOUN
bptjm-33	137	22	or	or	CCONJ
bptjm-33	137	23	csf	csf	NOUN
bptjm-33	137	24	.	.	PUNCT
bptjm-33	138	1	some	some	DET
bptjm-33	138	2	forms	form	NOUN
bptjm-33	138	3	of	of	ADP
bptjm-33	138	4	this	this	DET
bptjm-33	138	5	protein	protein	NOUN
bptjm-33	138	6	are	be	AUX
bptjm-33	138	7	toxic	toxic	ADJ
bptjm-33	138	8	and	and	CCONJ
bptjm-33	138	9	are	be	AUX
bptjm-33	138	10	known	know	VERB
bptjm-33	138	11	to	to	PART
bptjm-33	138	12	cause	cause	VERB
bptjm-33	138	13	neurotoxicity	neurotoxicity	NOUN
bptjm-33	138	14	,	,	PUNCT
bptjm-33	138	15	neuron	neuron	NOUN
bptjm-33	138	16	apoptosis	apoptosis	NOUN
bptjm-33	138	17	,	,	PUNCT
bptjm-33	138	18	inflammation	inflammation	NOUN
bptjm-33	138	19	,	,	PUNCT
bptjm-33	138	20	and	and	CCONJ
bptjm-33	138	21	synaptic	synaptic	ADJ
bptjm-33	138	22	loss	loss	NOUN
bptjm-33	138	23	,	,	PUNCT
bptjm-33	138	24	which	which	PRON
bptjm-33	138	25	all	all	PRON
bptjm-33	138	26	play	play	VERB
bptjm-33	138	27	a	a	DET
bptjm-33	138	28	role	role	NOUN
bptjm-33	138	29	in	in	ADP
bptjm-33	138	30	ad24,25,27	ad24,25,27	PROPN
bptjm-33	138	31	.	.	PUNCT
bptjm-33	139	1	the	the	DET
bptjm-33	139	2	buildup	buildup	NOUN
bptjm-33	139	3	of	of	ADP
bptjm-33	139	4	aβ	aβ	NOUN
bptjm-33	139	5	protein	protein	NOUN
bptjm-33	139	6	is	be	AUX
bptjm-33	139	7	deposited	deposit	VERB
bptjm-33	139	8	as	as	ADP
bptjm-33	139	9	plaque	plaque	NOUN
bptjm-33	139	10	in	in	ADP
bptjm-33	139	11	the	the	DET
bptjm-33	139	12	systems	system	NOUN
bptjm-33	139	13	of	of	ADP
bptjm-33	139	14	the	the	DET
bptjm-33	139	15	brain	brain	NOUN
bptjm-33	139	16	and	and	CCONJ
bptjm-33	139	17	cns	cns	NOUN
bptjm-33	139	18	,	,	PUNCT
bptjm-33	139	19	which	which	PRON
bptjm-33	139	20	in	in	ADP
bptjm-33	139	21	turn	turn	NOUN
bptjm-33	139	22	causes	cause	VERB
bptjm-33	139	23	increased	increase	VERB
bptjm-33	139	24	production	production	NOUN
bptjm-33	139	25	of	of	ADP
bptjm-33	139	26	proinflammatory	proinflammatory	ADJ
bptjm-33	139	27	cytokines	cytokine	NOUN
bptjm-33	139	28	.	.	PUNCT
bptjm-33	140	1	these	these	PRON
bptjm-33	140	2	cause	cause	VERB
bptjm-33	140	3	the	the	DET
bptjm-33	140	4	degeneration	degeneration	NOUN
bptjm-33	140	5	of	of	ADP
bptjm-33	140	6	glial	glial	ADJ
bptjm-33	140	7	cells	cell	NOUN
bptjm-33	140	8	and	and	CCONJ
bptjm-33	140	9	their	their	PRON
bptjm-33	140	10	tissue	tissue	NOUN
bptjm-33	140	11	,	,	PUNCT
bptjm-33	140	12	which	which	PRON
bptjm-33	140	13	causes	cause	VERB
bptjm-33	140	14	and	and	CCONJ
bptjm-33	140	15	progresses	progress	NOUN
bptjm-33	140	16	alzheimer’s25	alzheimer’s25	X
bptjm-33	140	17	.	.	PUNCT
bptjm-33	141	1	5.2	5.2	NUM
bptjm-33	141	2	.	.	PUNCT
bptjm-33	142	1	other	other	ADJ
bptjm-33	142	2	mirna	mirna	NOUN
bptjm-33	142	3	in	in	ADP
bptjm-33	142	4	pathogenesis	pathogenesis	NOUN
bptjm-33	142	5	of	of	ADP
bptjm-33	142	6	ad	ad	NOUN
bptjm-33	142	7	astrocytes	astrocyte	NOUN
bptjm-33	142	8	regulate	regulate	VERB
bptjm-33	142	9	ion	ion	NOUN
bptjm-33	142	10	homeostasis	homeostasis	NOUN
bptjm-33	142	11	in	in	ADP
bptjm-33	142	12	the	the	DET
bptjm-33	142	13	brain	brain	NOUN
bptjm-33	142	14	,	,	PUNCT
bptjm-33	142	15	and	and	CCONJ
bptjm-33	142	16	therefore	therefore	ADV
bptjm-33	142	17	,	,	PUNCT
bptjm-33	142	18	support	support	VERB
bptjm-33	142	19	neuronal	neuronal	ADJ
bptjm-33	142	20	function	function	NOUN
bptjm-33	142	21	.	.	PUNCT
bptjm-33	143	1	additionally	additionally	ADV
bptjm-33	143	2	,	,	PUNCT
bptjm-33	143	3	astrocytes	astrocyte	NOUN
bptjm-33	143	4	have	have	AUX
bptjm-33	143	5	been	be	AUX
bptjm-33	143	6	shown	show	VERB
bptjm-33	143	7	to	to	PART
bptjm-33	143	8	release	release	VERB
bptjm-33	143	9	cytokines	cytokine	NOUN
bptjm-33	143	10	which	which	PRON
bptjm-33	143	11	play	play	VERB
bptjm-33	143	12	a	a	DET
bptjm-33	143	13	crucial	crucial	ADJ
bptjm-33	143	14	role	role	NOUN
bptjm-33	143	15	in	in	ADP
bptjm-33	143	16	disease	disease	NOUN
bptjm-33	143	17	progression	progression	NOUN
bptjm-33	143	18	and	and	CCONJ
bptjm-33	143	19	creation25	creation25	NOUN
bptjm-33	143	20	.	.	PUNCT
bptjm-33	144	1	mirna	mirna	PROPN
bptjm-33	144	2	is	be	AUX
bptjm-33	144	3	an	an	DET
bptjm-33	144	4	important	important	ADJ
bptjm-33	144	5	immunoregulator	immunoregulator	NOUN
bptjm-33	144	6	,	,	PUNCT
bptjm-33	144	7	and	and	CCONJ
bptjm-33	144	8	an	an	DET
bptjm-33	144	9	imbalance	imbalance	NOUN
bptjm-33	144	10	in	in	ADP
bptjm-33	144	11	the	the	DET
bptjm-33	144	12	expression	expression	NOUN
bptjm-33	144	13	of	of	ADP
bptjm-33	144	14	specific	specific	ADJ
bptjm-33	144	15	mirnas	mirna	NOUN
bptjm-33	144	16	can	can	AUX
bptjm-33	144	17	cause	cause	VERB
bptjm-33	144	18	certain	certain	ADJ
bptjm-33	144	19	proteins	protein	NOUN
bptjm-33	144	20	or	or	CCONJ
bptjm-33	144	21	cytokines	cytokine	NOUN
bptjm-33	144	22	to	to	PART
bptjm-33	144	23	be	be	AUX
bptjm-33	144	24	over	over	ADP
bptjm-33	144	25	or	or	CCONJ
bptjm-33	144	26	under	under	ADV
bptjm-33	144	27	-	-	PUNCT
bptjm-33	144	28	produced	produce	VERB
bptjm-33	144	29	.	.	PUNCT
bptjm-33	145	1	for	for	ADP
bptjm-33	145	2	instance	instance	NOUN
bptjm-33	145	3	,	,	PUNCT
bptjm-33	145	4	an	an	DET
bptjm-33	145	5	excess	excess	NOUN
bptjm-33	145	6	of	of	ADP
bptjm-33	145	7	inflammatory	inflammatory	ADJ
bptjm-33	145	8	cytokines	cytokine	NOUN
bptjm-33	145	9	causes	cause	VERB
bptjm-33	145	10	the	the	DET
bptjm-33	145	11	nearby	nearby	ADJ
bptjm-33	145	12	neural	neural	ADJ
bptjm-33	145	13	cells	cell	NOUN
bptjm-33	145	14	and	and	CCONJ
bptjm-33	145	15	neurons	neuron	NOUN
bptjm-33	145	16	to	to	ADP
bptjm-33	145	17	die25	die25	PROPN
bptjm-33	145	18	.	.	PUNCT
bptjm-33	146	1	this	this	DET
bptjm-33	146	2	process	process	NOUN
bptjm-33	146	3	,	,	PUNCT
bptjm-33	146	4	along	along	ADP
bptjm-33	146	5	with	with	ADP
bptjm-33	146	6	the	the	DET
bptjm-33	146	7	amyloid	amyloid	NOUN
bptjm-33	146	8	cascade	cascade	NOUN
bptjm-33	146	9	hypothesis	hypothesis	NOUN
bptjm-33	146	10	,	,	PUNCT
bptjm-33	146	11	has	have	AUX
bptjm-33	146	12	shown	show	VERB
bptjm-33	146	13	that	that	SCONJ
bptjm-33	146	14	although	although	SCONJ
bptjm-33	146	15	ad	ad	NOUN
bptjm-33	146	16	can	can	AUX
bptjm-33	146	17	not	not	PART
bptjm-33	146	18	be	be	AUX
bptjm-33	146	19	pinpointed	pinpoint	VERB
bptjm-33	146	20	to	to	ADP
bptjm-33	146	21	one	one	NUM
bptjm-33	146	22	specific	specific	ADJ
bptjm-33	146	23	trigger	trigger	NOUN
bptjm-33	146	24	or	or	CCONJ
bptjm-33	146	25	cause	cause	NOUN
bptjm-33	146	26	,	,	PUNCT
bptjm-33	146	27	the	the	DET
bptjm-33	146	28	levels	level	NOUN
bptjm-33	146	29	of	of	ADP
bptjm-33	146	30	particular	particular	ADJ
bptjm-33	146	31	mirna	mirna	NOUN
bptjm-33	146	32	play	play	VERB
bptjm-33	146	33	a	a	DET
bptjm-33	146	34	role	role	NOUN
bptjm-33	146	35	in	in	ADP
bptjm-33	146	36	the	the	DET
bptjm-33	146	37	existence	existence	NOUN
bptjm-33	146	38	,	,	PUNCT
bptjm-33	146	39	pathogenesis	pathogenesis	NOUN
bptjm-33	146	40	,	,	PUNCT
bptjm-33	146	41	and	and	CCONJ
bptjm-33	146	42	pathophysiology	pathophysiology	NOUN
bptjm-33	146	43	of	of	ADP
bptjm-33	146	44	ad	ad	NOUN
bptjm-33	146	45	.	.	PUNCT
bptjm-33	147	1	5.3	5.3	NUM
bptjm-33	147	2	.	.	PUNCT
bptjm-33	147	3	specific	specific	ADJ
bptjm-33	147	4	mirnas	mirna	NOUN
bptjm-33	147	5	as	as	ADP
bptjm-33	147	6	biomarkers	biomarker	NOUN
bptjm-33	147	7	there	there	ADV
bptjm-33	147	8	are	be	VERB
bptjm-33	147	9	many	many	ADJ
bptjm-33	147	10	studies	study	NOUN
bptjm-33	147	11	that	that	PRON
bptjm-33	147	12	show	show	VERB
bptjm-33	147	13	patterns	pattern	NOUN
bptjm-33	147	14	in	in	ADP
bptjm-33	147	15	the	the	DET
bptjm-33	147	16	levels	level	NOUN
bptjm-33	147	17	of	of	ADP
bptjm-33	147	18	expression	expression	NOUN
bptjm-33	147	19	of	of	ADP
bptjm-33	147	20	specific	specific	ADJ
bptjm-33	147	21	mirna	mirna	NOUN
bptjm-33	147	22	segments	segment	NOUN
bptjm-33	147	23	that	that	PRON
bptjm-33	147	24	relate	relate	VERB
bptjm-33	147	25	to	to	ADP
bptjm-33	147	26	ad26	ad26	PROPN
bptjm-33	147	27	.	.	PUNCT
bptjm-33	148	1	in	in	ADP
bptjm-33	148	2	the	the	DET
bptjm-33	148	3	serum	serum	NOUN
bptjm-33	148	4	of	of	ADP
bptjm-33	148	5	ad	ad	NOUN
bptjm-33	148	6	patients	patient	NOUN
bptjm-33	148	7	,	,	PUNCT
bptjm-33	148	8	segments	segment	NOUN
bptjm-33	148	9	such	such	ADJ
bptjm-33	148	10	as	as	ADP
bptjm-33	148	11	mir-149	mir-149	NOUN
bptjm-33	148	12	,	,	PUNCT
bptjm-33	148	13	mir-34a-5p	mir-34a-5p	PROPN
bptjm-33	148	14	,	,	PUNCT
bptjm-33	148	15	mir-125b-5p	mir-125b-5p	PROPN
bptjm-33	148	16	,	,	PUNCT
bptjm-33	148	17	mir-15b	mir-15b	PROPN
bptjm-33	148	18	,	,	PUNCT
bptjm-33	148	19	mir-16	mir-16	PROPN
bptjm-33	148	20	,	,	PUNCT
bptjm-33	148	21	berkeley	berkeley	PROPN
bptjm-33	148	22	pharma	pharma	PROPN
bptjm-33	148	23	tech	tech	NOUN
bptjm-33	148	24	journal	journal	NOUN
bptjm-33	148	25	of	of	ADP
bptjm-33	148	26	medicine	medicine	NOUN
bptjm-33	149	1	|	|	ADV
bptjm-33	149	2	60	60	NUM
bptjm-33	149	3	mir-124	mir-124	NOUN
bptjm-33	149	4	,	,	PUNCT
bptjm-33	149	5	mir-29c	mir-29c	PUNCT
bptjm-33	149	6	and	and	CCONJ
bptjm-33	149	7	mir-374b-5p	mir-374b-5p	PROPN
bptjm-33	149	8	were	be	AUX
bptjm-33	149	9	all	all	PRON
bptjm-33	149	10	found	find	VERB
bptjm-33	149	11	in	in	ADP
bptjm-33	149	12	reduced	reduce	VERB
bptjm-33	149	13	quantities	quantity	NOUN
bptjm-33	149	14	when	when	SCONJ
bptjm-33	149	15	compared	compare	VERB
bptjm-33	149	16	to	to	ADP
bptjm-33	149	17	healthy	healthy	ADJ
bptjm-33	149	18	individuals27	individuals27	NOUN
bptjm-33	149	19	.	.	PUNCT
bptjm-33	150	1	out	out	ADP
bptjm-33	150	2	of	of	ADP
bptjm-33	150	3	these	these	PRON
bptjm-33	150	4	,	,	PUNCT
bptjm-33	150	5	mir-149	mir-149	ADJ
bptjm-33	150	6	,	,	PUNCT
bptjm-33	150	7	mir-34a5p	mir-34a5p	NOUN
bptjm-33	150	8	,	,	PUNCT
bptjm-33	150	9	mir-16	mir-16	NOUN
bptjm-33	150	10	,	,	PUNCT
bptjm-33	150	11	mir-29c	mir-29c	PUNCT
bptjm-33	150	12	and	and	CCONJ
bptjm-33	150	13	mir-374b-5p	mir-374b-5p	PROPN
bptjm-33	150	14	were	be	AUX
bptjm-33	150	15	found	find	VERB
bptjm-33	150	16	to	to	PART
bptjm-33	150	17	directly	directly	ADV
bptjm-33	150	18	target	target	VERB
bptjm-33	150	19	bace127	bace127	PROPN
bptjm-33	150	20	.	.	PUNCT
bptjm-33	151	1	this	this	PRON
bptjm-33	151	2	relates	relate	VERB
bptjm-33	151	3	to	to	ADP
bptjm-33	151	4	the	the	DET
bptjm-33	151	5	upregulation	upregulation	NOUN
bptjm-33	151	6	of	of	ADP
bptjm-33	151	7	bace-1	bace-1	PROPN
bptjm-33	151	8	found	find	VERB
bptjm-33	151	9	in	in	ADP
bptjm-33	151	10	ad	ad	NOUN
bptjm-33	151	11	patients	patient	NOUN
bptjm-33	151	12	,	,	PUNCT
bptjm-33	151	13	which	which	PRON
bptjm-33	151	14	in	in	ADP
bptjm-33	151	15	turn	turn	NOUN
bptjm-33	151	16	cleaves	cleave	VERB
bptjm-33	151	17	the	the	DET
bptjm-33	151	18	app	app	NOUN
bptjm-33	151	19	and	and	CCONJ
bptjm-33	151	20	promotes	promote	VERB
bptjm-33	151	21	the	the	DET
bptjm-33	151	22	production	production	NOUN
bptjm-33	151	23	of	of	ADP
bptjm-33	151	24	aβ	aβ	PRON
bptjm-33	151	25	proteins	protein	NOUN
bptjm-33	151	26	.	.	PUNCT
bptjm-33	152	1	there	there	PRON
bptjm-33	152	2	were	be	VERB
bptjm-33	152	3	other	other	ADJ
bptjm-33	152	4	mirnas	mirna	NOUN
bptjm-33	152	5	,	,	PUNCT
bptjm-33	152	6	such	such	ADJ
bptjm-33	152	7	as	as	ADP
bptjm-33	152	8	mir-146a	mir-146a	ADJ
bptjm-33	152	9	and	and	CCONJ
bptjm-33	152	10	mir-181a	mir-181a	NOUN
bptjm-33	152	11	,	,	PUNCT
bptjm-33	152	12	which	which	PRON
bptjm-33	152	13	were	be	AUX
bptjm-33	152	14	found	find	VERB
bptjm-33	152	15	in	in	ADP
bptjm-33	152	16	higher	high	ADJ
bptjm-33	152	17	concentrations	concentration	NOUN
bptjm-33	152	18	in	in	ADP
bptjm-33	152	19	ad	ad	NOUN
bptjm-33	152	20	patients	patient	NOUN
bptjm-33	152	21	,	,	PUNCT
bptjm-33	152	22	more	more	ADV
bptjm-33	152	23	specifically	specifically	ADV
bptjm-33	152	24	in	in	ADP
bptjm-33	152	25	patients	patient	NOUN
bptjm-33	152	26	who	who	PRON
bptjm-33	152	27	initially	initially	ADV
bptjm-33	152	28	had	have	VERB
bptjm-33	152	29	mild	mild	ADJ
bptjm-33	152	30	cognitive	cognitive	ADJ
bptjm-33	152	31	impairment	impairment	NOUN
bptjm-33	152	32	(	(	PUNCT
bptjm-33	152	33	mci	mci	NOUN
bptjm-33	152	34	)	)	PUNCT
bptjm-33	152	35	and	and	CCONJ
bptjm-33	152	36	later	later	ADV
bptjm-33	152	37	progressed	progress	VERB
bptjm-33	152	38	into	into	ADP
bptjm-33	152	39	ad21	ad21	PROPN
bptjm-33	152	40	.	.	PUNCT
bptjm-33	153	1	in	in	ADP
bptjm-33	153	2	different	different	ADJ
bptjm-33	153	3	parts	part	NOUN
bptjm-33	153	4	of	of	ADP
bptjm-33	153	5	the	the	DET
bptjm-33	153	6	body	body	NOUN
bptjm-33	153	7	,	,	PUNCT
bptjm-33	153	8	the	the	DET
bptjm-33	153	9	expression	expression	NOUN
bptjm-33	153	10	levels	level	NOUN
bptjm-33	153	11	of	of	ADP
bptjm-33	153	12	different	different	ADJ
bptjm-33	153	13	mirnas	mirna	NOUN
bptjm-33	153	14	were	be	AUX
bptjm-33	153	15	shown	show	VERB
bptjm-33	153	16	to	to	PART
bptjm-33	153	17	have	have	VERB
bptjm-33	153	18	similar	similar	ADJ
bptjm-33	153	19	patterns	pattern	NOUN
bptjm-33	153	20	.	.	PUNCT
bptjm-33	154	1	the	the	DET
bptjm-33	154	2	downregulation	downregulation	NOUN
bptjm-33	154	3	of	of	ADP
bptjm-33	154	4	mir132/212	mir132/212	PROPN
bptjm-33	154	5	and	and	CCONJ
bptjm-33	154	6	mir-335–5p	mir-335–5p	PROPN
bptjm-33	154	7	in	in	ADP
bptjm-33	154	8	the	the	DET
bptjm-33	154	9	brain	brain	NOUN
bptjm-33	154	10	tissues	tissue	NOUN
bptjm-33	154	11	were	be	AUX
bptjm-33	154	12	found	find	VERB
bptjm-33	154	13	in	in	ADP
bptjm-33	154	14	ad	ad	NOUN
bptjm-33	154	15	patients	patient	NOUN
bptjm-33	154	16	,	,	PUNCT
bptjm-33	154	17	which	which	PRON
bptjm-33	154	18	caused	cause	VERB
bptjm-33	154	19	a	a	DET
bptjm-33	154	20	higher	high	ADJ
bptjm-33	154	21	production	production	NOUN
bptjm-33	154	22	of	of	ADP
bptjm-33	154	23	aβ	aβ	PRON
bptjm-33	154	24	and	and	CCONJ
bptjm-33	154	25	more	more	ADJ
bptjm-33	154	26	plaque	plaque	ADJ
bptjm-33	154	27	buildup	buildup	NOUN
bptjm-33	154	28	in	in	ADP
bptjm-33	154	29	the	the	DET
bptjm-33	154	30	brain	brain	NOUN
bptjm-33	154	31	,	,	PUNCT
bptjm-33	154	32	causing	cause	VERB
bptjm-33	154	33	symptoms	symptom	NOUN
bptjm-33	154	34	consistent	consistent	ADJ
bptjm-33	154	35	with	with	ADP
bptjm-33	154	36	the	the	DET
bptjm-33	154	37	disease26	disease26	NOUN
bptjm-33	154	38	.	.	PUNCT
bptjm-33	155	1	generally	generally	ADV
bptjm-33	155	2	,	,	PUNCT
bptjm-33	155	3	mirna	mirna	PROPN
bptjm-33	155	4	has	have	AUX
bptjm-33	155	5	shown	show	VERB
bptjm-33	155	6	to	to	PART
bptjm-33	155	7	be	be	AUX
bptjm-33	155	8	strongly	strongly	ADV
bptjm-33	155	9	related	relate	VERB
bptjm-33	155	10	to	to	ADP
bptjm-33	155	11	the	the	DET
bptjm-33	155	12	pathophysiology	pathophysiology	NOUN
bptjm-33	155	13	of	of	ADP
bptjm-33	155	14	alzheimer	alzheimer	PROPN
bptjm-33	155	15	’s	’s	PART
bptjm-33	155	16	and	and	CCONJ
bptjm-33	155	17	plays	play	VERB
bptjm-33	155	18	a	a	DET
bptjm-33	155	19	direct	direct	ADJ
bptjm-33	155	20	role	role	NOUN
bptjm-33	155	21	in	in	ADP
bptjm-33	155	22	many	many	ADJ
bptjm-33	155	23	of	of	ADP
bptjm-33	155	24	the	the	DET
bptjm-33	155	25	genes	gene	NOUN
bptjm-33	155	26	of	of	ADP
bptjm-33	155	27	interest	interest	NOUN
bptjm-33	155	28	.	.	PUNCT
bptjm-33	156	1	6	6	X
bptjm-33	156	2	.	.	X
bptjm-33	156	3	genes	gene	NOUN
bptjm-33	156	4	/	/	SYM
bptjm-33	156	5	factors	factor	NOUN
bptjm-33	156	6	of	of	ADP
bptjm-33	156	7	interest	interest	NOUN
bptjm-33	156	8	6.1	6.1	NUM
bptjm-33	156	9	.	.	PUNCT
bptjm-33	157	1	app	app	PROPN
bptjm-33	157	2	studies	study	NOUN
bptjm-33	157	3	have	have	AUX
bptjm-33	157	4	indicated	indicate	VERB
bptjm-33	157	5	that	that	SCONJ
bptjm-33	157	6	an	an	DET
bptjm-33	157	7	increased	increase	VERB
bptjm-33	157	8	app	app	NOUN
bptjm-33	157	9	level	level	NOUN
bptjm-33	157	10	due	due	ADP
bptjm-33	157	11	to	to	ADP
bptjm-33	157	12	genomic	genomic	ADJ
bptjm-33	157	13	locus	locus	NOUN
bptjm-33	157	14	duplication	duplication	NOUN
bptjm-33	157	15	or	or	CCONJ
bptjm-33	157	16	mutation	mutation	NOUN
bptjm-33	157	17	in	in	ADP
bptjm-33	157	18	the	the	DET
bptjm-33	157	19	app	app	NOUN
bptjm-33	157	20	regulatory	regulatory	ADJ
bptjm-33	157	21	sequences	sequence	NOUN
bptjm-33	157	22	can	can	AUX
bptjm-33	157	23	result	result	VERB
bptjm-33	157	24	in	in	ADP
bptjm-33	157	25	the	the	DET
bptjm-33	157	26	development	development	NOUN
bptjm-33	157	27	of	of	ADP
bptjm-33	157	28	early	early	ADJ
bptjm-33	157	29	-	-	PUNCT
bptjm-33	157	30	onset	onset	NOUN
bptjm-33	157	31	dementias	dementia	NOUN
bptjm-33	157	32	,	,	PUNCT
bptjm-33	157	33	including	include	VERB
bptjm-33	157	34	ad	ad	NOUN
bptjm-33	157	35	.	.	PUNCT
bptjm-33	158	1	app	app	PROPN
bptjm-33	158	2	regulation	regulation	NOUN
bptjm-33	158	3	is	be	AUX
bptjm-33	158	4	of	of	ADP
bptjm-33	158	5	special	special	ADJ
bptjm-33	158	6	interest	interest	NOUN
bptjm-33	158	7	as	as	SCONJ
bptjm-33	158	8	it	it	PRON
bptjm-33	158	9	provides	provide	VERB
bptjm-33	158	10	valuable	valuable	ADJ
bptjm-33	158	11	insight	insight	NOUN
bptjm-33	158	12	into	into	ADP
bptjm-33	158	13	the	the	DET
bptjm-33	158	14	genetic	genetic	ADJ
bptjm-33	158	15	basis	basis	NOUN
bptjm-33	158	16	of	of	ADP
bptjm-33	158	17	ad	ad	NOUN
bptjm-33	158	18	and	and	CCONJ
bptjm-33	158	19	its	its	PRON
bptjm-33	158	20	novel	novel	ADJ
bptjm-33	158	21	therapeutics	therapeutic	NOUN
bptjm-33	158	22	.	.	PUNCT
bptjm-33	159	1	a	a	DET
bptjm-33	159	2	study	study	NOUN
bptjm-33	159	3	that	that	PRON
bptjm-33	159	4	tested	test	VERB
bptjm-33	159	5	the	the	DET
bptjm-33	159	6	regulatory	regulatory	ADJ
bptjm-33	159	7	effect	effect	NOUN
bptjm-33	159	8	of	of	ADP
bptjm-33	159	9	mirnas	mirna	NOUN
bptjm-33	159	10	on	on	ADP
bptjm-33	159	11	the	the	DET
bptjm-33	159	12	level	level	NOUN
bptjm-33	159	13	of	of	ADP
bptjm-33	159	14	app	app	NOUN
bptjm-33	159	15	gene	gene	NOUN
bptjm-33	159	16	expression	expression	NOUN
bptjm-33	159	17	demonstrated	demonstrate	VERB
bptjm-33	159	18	that	that	SCONJ
bptjm-33	159	19	complementary	complementary	ADJ
bptjm-33	159	20	binding	binding	NOUN
bptjm-33	159	21	between	between	ADP
bptjm-33	159	22	mirnas	mirna	NOUN
bptjm-33	159	23	hsa	hsa	PROPN
bptjm-33	159	24	-	-	PUNCT
bptjm-33	159	25	mir-106a	mir-106a	ADJ
bptjm-33	159	26	and	and	CCONJ
bptjm-33	159	27	hsa	hsa	NOUN
bptjm-33	159	28	-	-	PUNCT
bptjm-33	159	29	mir-520c	mir-520c	NOUN
bptjm-33	159	30	and	and	CCONJ
bptjm-33	159	31	their	their	PRON
bptjm-33	159	32	predicted	predict	VERB
bptjm-33	159	33	target	target	NOUN
bptjm-33	159	34	sequences	sequence	NOUN
bptjm-33	159	35	within	within	ADP
bptjm-33	159	36	the	the	DET
bptjm-33	159	37	3	3	NUM
bptjm-33	159	38	'	'	PART
bptjm-33	159	39	utr	utr	NOUN
bptjm-33	159	40	of	of	ADP
bptjm-33	159	41	app	app	NOUN
bptjm-33	159	42	genes	gene	NOUN
bptjm-33	159	43	results	result	VERB
bptjm-33	159	44	in	in	ADP
bptjm-33	159	45	repression	repression	NOUN
bptjm-33	159	46	of	of	ADP
bptjm-33	159	47	reporter	reporter	NOUN
bptjm-33	159	48	gene	gene	NOUN
bptjm-33	159	49	expression	expression	NOUN
bptjm-33	159	50	,	,	PUNCT
bptjm-33	159	51	and	and	CCONJ
bptjm-33	159	52	that	that	SCONJ
bptjm-33	159	53	over	over	ADP
bptjm-33	159	54	-	-	PUNCT
bptjm-33	159	55	expression	expression	NOUN
bptjm-33	159	56	of	of	ADP
bptjm-33	159	57	these	these	DET
bptjm-33	159	58	mirnas	mirna	NOUN
bptjm-33	159	59	resulted	result	VERB
bptjm-33	159	60	in	in	ADP
bptjm-33	159	61	translational	translational	ADJ
bptjm-33	159	62	repression	repression	NOUN
bptjm-33	159	63	of	of	ADP
bptjm-33	159	64	app	app	PROPN
bptjm-33	159	65	mrna	mrna	PROPN
bptjm-33	159	66	and	and	CCONJ
bptjm-33	159	67	significantly	significantly	ADV
bptjm-33	159	68	reduced	reduce	VERB
bptjm-33	159	69	app	app	NOUN
bptjm-33	159	70	protein	protein	NOUN
bptjm-33	159	71	levels	level	NOUN
bptjm-33	159	72	in	in	ADP
bptjm-33	159	73	human	human	ADJ
bptjm-33	159	74	cell	cell	NOUN
bptjm-33	159	75	lines	line	NOUN
bptjm-33	159	76	.	.	PUNCT
bptjm-33	160	1	these	these	DET
bptjm-33	160	2	results	result	NOUN
bptjm-33	160	3	were	be	AUX
bptjm-33	160	4	the	the	DET
bptjm-33	160	5	first	first	ADJ
bptjm-33	160	6	to	to	PART
bptjm-33	160	7	experimentally	experimentally	ADV
bptjm-33	160	8	demonstrate	demonstrate	VERB
bptjm-33	160	9	the	the	DET
bptjm-33	160	10	post	post	ADJ
bptjm-33	160	11	-	-	ADJ
bptjm-33	160	12	transcriptional	transcriptional	ADJ
bptjm-33	160	13	regulatory	regulatory	ADJ
bptjm-33	160	14	role	role	NOUN
bptjm-33	160	15	of	of	ADP
bptjm-33	160	16	mirna	mirna	NOUN
bptjm-33	160	17	in	in	ADP
bptjm-33	160	18	the	the	DET
bptjm-33	160	19	levels	level	NOUN
bptjm-33	160	20	of	of	ADP
bptjm-33	160	21	human	human	ADJ
bptjm-33	160	22	app28	app28	NOUN
bptjm-33	160	23	.	.	PUNCT
bptjm-33	161	1	on	on	ADP
bptjm-33	161	2	the	the	DET
bptjm-33	161	3	other	other	ADJ
bptjm-33	161	4	hand	hand	NOUN
bptjm-33	161	5	,	,	PUNCT
bptjm-33	161	6	another	another	DET
bptjm-33	161	7	study	study	NOUN
bptjm-33	161	8	has	have	AUX
bptjm-33	161	9	demonstrated	demonstrate	VERB
bptjm-33	161	10	the	the	DET
bptjm-33	161	11	activity	activity	NOUN
bptjm-33	161	12	of	of	ADP
bptjm-33	161	13	mir-346	mir-346	NOUN
bptjm-33	161	14	,	,	PUNCT
bptjm-33	161	15	which	which	PRON
bptjm-33	161	16	requires	require	VERB
bptjm-33	161	17	the	the	DET
bptjm-33	161	18	chelation	chelation	NOUN
bptjm-33	161	19	of	of	ADP
bptjm-33	161	20	an	an	DET
bptjm-33	161	21	intracellular	intracellular	ADJ
bptjm-33	161	22	iron	iron	NOUN
bptjm-33	161	23	fe	fe	NOUN
bptjm-33	161	24	,	,	PUNCT
bptjm-33	161	25	that	that	PRON
bptjm-33	161	26	targets	target	VERB
bptjm-33	161	27	the	the	DET
bptjm-33	161	28	app	app	NOUN
bptjm-33	161	29	mrna	mrna	PROPN
bptjm-33	161	30	5′-utr	5′-utr	PROPN
bptjm-33	161	31	to	to	PART
bptjm-33	161	32	upregulate	upregulate	VERB
bptjm-33	161	33	app	app	NOUN
bptjm-33	161	34	translation	translation	NOUN
bptjm-33	161	35	and	and	CCONJ
bptjm-33	161	36	aβ	aβ	DET
bptjm-33	161	37	production	production	NOUN
bptjm-33	161	38	.	.	PUNCT
bptjm-33	162	1	it	it	PRON
bptjm-33	162	2	has	have	AUX
bptjm-33	162	3	also	also	ADV
bptjm-33	162	4	been	be	AUX
bptjm-33	162	5	found	find	VERB
bptjm-33	162	6	that	that	SCONJ
bptjm-33	162	7	mir-346	mir-346	ADJ
bptjm-33	162	8	levels	level	NOUN
bptjm-33	162	9	are	be	AUX
bptjm-33	162	10	altered	alter	VERB
bptjm-33	162	11	in	in	ADP
bptjm-33	162	12	late	late	ADJ
bptjm-33	162	13	-	-	PUNCT
bptjm-33	162	14	braak	braak	NOUN
bptjm-33	162	15	stage	stage	NOUN
bptjm-33	162	16	ad	ad	NOUN
bptjm-33	162	17	.	.	PUNCT
bptjm-33	163	1	as	as	ADP
bptjm-33	163	2	a	a	DET
bptjm-33	163	3	result	result	NOUN
bptjm-33	163	4	,	,	PUNCT
bptjm-33	163	5	mir-346	mir-346	PROPN
bptjm-33	163	6	leads	lead	VERB
bptjm-33	163	7	to	to	ADP
bptjm-33	163	8	the	the	DET
bptjm-33	163	9	upregulation	upregulation	NOUN
bptjm-33	163	10	of	of	ADP
bptjm-33	163	11	app	app	NOUN
bptjm-33	163	12	in	in	ADP
bptjm-33	163	13	the	the	DET
bptjm-33	163	14	cns	cns	NOUN
bptjm-33	163	15	,	,	PUNCT
bptjm-33	163	16	and	and	CCONJ
bptjm-33	163	17	participate	participate	VERB
bptjm-33	163	18	in	in	ADP
bptjm-33	163	19	maintaining	maintain	VERB
bptjm-33	163	20	app	app	PROPN
bptjm-33	163	21	berkeley	berkeley	PROPN
bptjm-33	163	22	pharma	pharma	PROPN
bptjm-33	163	23	tech	tech	NOUN
bptjm-33	163	24	journal	journal	NOUN
bptjm-33	163	25	of	of	ADP
bptjm-33	163	26	medicine	medicine	NOUN
bptjm-33	163	27	|	|	ADV
bptjm-33	163	28	61	61	NUM
bptjm-33	163	29	regulation	regulation	NOUN
bptjm-33	163	30	of	of	ADP
bptjm-33	163	31	fe	fe	NOUN
bptjm-33	163	32	,	,	PUNCT
bptjm-33	163	33	which	which	PRON
bptjm-33	163	34	is	be	AUX
bptjm-33	163	35	disrupted	disrupt	VERB
bptjm-33	163	36	in	in	ADP
bptjm-33	163	37	the	the	DET
bptjm-33	163	38	late	late	ADJ
bptjm-33	163	39	stages	stage	NOUN
bptjm-33	163	40	of	of	ADP
bptjm-33	163	41	ad29	ad29	PROPN
bptjm-33	163	42	.	.	PUNCT
bptjm-33	164	1	substantial	substantial	ADJ
bptjm-33	164	2	progress	progress	NOUN
bptjm-33	164	3	towards	towards	ADP
bptjm-33	164	4	understanding	understand	VERB
bptjm-33	164	5	the	the	DET
bptjm-33	164	6	role	role	NOUN
bptjm-33	164	7	of	of	ADP
bptjm-33	164	8	mirna	mirna	NOUN
bptjm-33	164	9	-	-	PUNCT
bptjm-33	164	10	induced	induce	VERB
bptjm-33	164	11	alterations	alteration	NOUN
bptjm-33	164	12	in	in	ADP
bptjm-33	164	13	the	the	DET
bptjm-33	164	14	app	app	NOUN
bptjm-33	164	15	gene	gene	NOUN
bptjm-33	164	16	expression	expression	NOUN
bptjm-33	164	17	and	and	CCONJ
bptjm-33	164	18	aβ	aβ	PRON
bptjm-33	164	19	production	production	NOUN
bptjm-33	164	20	levels	level	NOUN
bptjm-33	164	21	and	and	CCONJ
bptjm-33	164	22	the	the	DET
bptjm-33	164	23	multifaceted	multifaceted	ADJ
bptjm-33	164	24	biological	biological	ADJ
bptjm-33	164	25	involvement	involvement	NOUN
bptjm-33	164	26	of	of	ADP
bptjm-33	164	27	mirnas	mirna	NOUN
bptjm-33	164	28	in	in	ADP
bptjm-33	164	29	app	app	NOUN
bptjm-33	164	30	metabolism	metabolism	NOUN
bptjm-33	164	31	is	be	AUX
bptjm-33	164	32	of	of	ADP
bptjm-33	164	33	interest	interest	NOUN
bptjm-33	164	34	to	to	ADP
bptjm-33	164	35	current	current	ADJ
bptjm-33	164	36	research	research	NOUN
bptjm-33	164	37	underlying	underlie	VERB
bptjm-33	164	38	the	the	DET
bptjm-33	164	39	pathophysiology	pathophysiology	NOUN
bptjm-33	164	40	of	of	ADP
bptjm-33	164	41	ad28,29	ad28,29	NOUN
bptjm-33	164	42	.	.	PUNCT
bptjm-33	165	1	6.2	6.2	NUM
bptjm-33	165	2	.	.	PUNCT
bptjm-33	166	1	hyperphosphorylated	hyperphosphorylate	VERB
bptjm-33	166	2	tau	tau	PROPN
bptjm-33	166	3	peptide	peptide	NOUN
bptjm-33	166	4	(	(	PUNCT
bptjm-33	166	5	p	p	PROPN
bptjm-33	166	6	-	-	PUNCT
bptjm-33	166	7	tau	tau	NOUN
bptjm-33	166	8	)	)	PUNCT
bptjm-33	166	9	several	several	ADJ
bptjm-33	166	10	functional	functional	ADJ
bptjm-33	166	11	in	in	ADP
bptjm-33	166	12	vivo	vivo	ADJ
bptjm-33	166	13	studies	study	NOUN
bptjm-33	166	14	have	have	AUX
bptjm-33	166	15	demonstrated	demonstrate	VERB
bptjm-33	166	16	the	the	DET
bptjm-33	166	17	potential	potential	NOUN
bptjm-33	166	18	of	of	ADP
bptjm-33	166	19	microrna-23b-3p	microrna-23b-3p	PROPN
bptjm-33	166	20	(	(	PUNCT
bptjm-33	166	21	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	166	22	)	)	PUNCT
bptjm-33	166	23	in	in	ADP
bptjm-33	166	24	various	various	ADJ
bptjm-33	166	25	neurologic	neurologic	ADJ
bptjm-33	166	26	disorders30	disorders30	NOUN
bptjm-33	166	27	.	.	PUNCT
bptjm-33	167	1	study	study	NOUN
bptjm-33	167	2	results	result	NOUN
bptjm-33	167	3	support	support	VERB
bptjm-33	167	4	the	the	DET
bptjm-33	167	5	potent	potent	ADJ
bptjm-33	167	6	involvement	involvement	NOUN
bptjm-33	167	7	of	of	ADP
bptjm-33	167	8	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	167	9	as	as	ADP
bptjm-33	167	10	a	a	DET
bptjm-33	167	11	neuroprotectant	neuroprotectant	NOUN
bptjm-33	167	12	in	in	ADP
bptjm-33	167	13	ad	ad	NOUN
bptjm-33	167	14	.	.	PUNCT
bptjm-33	168	1	functional	functional	ADJ
bptjm-33	168	2	in	in	ADP
bptjm-33	168	3	vivo	vivo	ADJ
bptjm-33	168	4	studies	study	NOUN
bptjm-33	168	5	demonstrated	demonstrate	VERB
bptjm-33	168	6	that	that	SCONJ
bptjm-33	168	7	intracerebroventricular	intracerebroventricular	ADJ
bptjm-33	168	8	delivery	delivery	NOUN
bptjm-33	168	9	of	of	ADP
bptjm-33	168	10	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	168	11	in	in	ADP
bptjm-33	168	12	app	app	PROPN
bptjm-33	168	13	/	/	SYM
bptjm-33	168	14	ps1	ps1	NOUN
bptjm-33	168	15	mice	mouse	NOUN
bptjm-33	168	16	reduced	reduce	VERB
bptjm-33	168	17	cognitive	cognitive	ADJ
bptjm-33	168	18	impairment	impairment	NOUN
bptjm-33	168	19	and	and	CCONJ
bptjm-33	168	20	p	p	PROPN
bptjm-33	168	21	-	-	PUNCT
bptjm-33	168	22	tau	tau	NOUN
bptjm-33	168	23	levels	level	NOUN
bptjm-33	168	24	,	,	PUNCT
bptjm-33	168	25	while	while	SCONJ
bptjm-33	168	26	upregulation	upregulation	NOUN
bptjm-33	168	27	of	of	ADP
bptjm-33	168	28	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	168	29	resulted	result	VERB
bptjm-33	168	30	in	in	ADP
bptjm-33	168	31	an	an	DET
bptjm-33	168	32	increased	increase	VERB
bptjm-33	168	33	level	level	NOUN
bptjm-33	168	34	of	of	ADP
bptjm-33	168	35	p	p	PROPN
bptjm-33	168	36	-	-	PUNCT
bptjm-33	168	37	tau	tau	NOUN
bptjm-33	168	38	,	,	PUNCT
bptjm-33	168	39	aβ	aβ	DET
bptjm-33	168	40	production	production	NOUN
bptjm-33	168	41	,	,	PUNCT
bptjm-33	168	42	and	and	CCONJ
bptjm-33	168	43	neuronal	neuronal	ADJ
bptjm-33	168	44	apoptosis	apoptosis	NOUN
bptjm-33	168	45	.	.	PUNCT
bptjm-33	169	1	these	these	DET
bptjm-33	169	2	results	result	NOUN
bptjm-33	169	3	thereby	thereby	ADV
bptjm-33	169	4	identify	identify	VERB
bptjm-33	169	5	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	169	6	as	as	ADP
bptjm-33	169	7	a	a	DET
bptjm-33	169	8	promising	promising	ADJ
bptjm-33	169	9	therapeutic	therapeutic	ADJ
bptjm-33	169	10	target	target	NOUN
bptjm-33	169	11	for	for	ADP
bptjm-33	169	12	ad30	ad30	PROPN
bptjm-33	169	13	.	.	PUNCT
bptjm-33	170	1	several	several	ADJ
bptjm-33	170	2	studies	study	NOUN
bptjm-33	170	3	have	have	AUX
bptjm-33	170	4	speculated	speculate	VERB
bptjm-33	170	5	the	the	DET
bptjm-33	170	6	functional	functional	ADJ
bptjm-33	170	7	role	role	NOUN
bptjm-33	170	8	of	of	ADP
bptjm-33	170	9	tau	tau	PROPN
bptjm-33	170	10	in	in	ADP
bptjm-33	170	11	promoting	promote	VERB
bptjm-33	170	12	microtubule	microtubule	NOUN
bptjm-33	170	13	assembly	assembly	NOUN
bptjm-33	170	14	,	,	PUNCT
bptjm-33	170	15	stabilization	stabilization	NOUN
bptjm-33	170	16	,	,	PUNCT
bptjm-33	170	17	and	and	CCONJ
bptjm-33	170	18	spacing	space	VERB
bptjm-33	170	19	necessary	necessary	ADJ
bptjm-33	170	20	for	for	ADP
bptjm-33	170	21	axonal	axonal	ADJ
bptjm-33	170	22	transport	transport	NOUN
bptjm-33	170	23	.	.	PUNCT
bptjm-33	171	1	moreover	moreover	ADV
bptjm-33	171	2	,	,	PUNCT
bptjm-33	171	3	6	6	NUM
bptjm-33	171	4	isoforms	isoform	NOUN
bptjm-33	171	5	of	of	ADP
bptjm-33	171	6	tau	tau	PROPN
bptjm-33	171	7	are	be	AUX
bptjm-33	171	8	present	present	ADJ
bptjm-33	171	9	in	in	ADP
bptjm-33	171	10	the	the	DET
bptjm-33	171	11	central	central	ADJ
bptjm-33	171	12	nervous	nervous	ADJ
bptjm-33	171	13	system	system	NOUN
bptjm-33	171	14	due	due	ADP
bptjm-33	171	15	to	to	ADP
bptjm-33	171	16	the	the	DET
bptjm-33	171	17	inclusion	inclusion	NOUN
bptjm-33	171	18	and	and	CCONJ
bptjm-33	171	19	exclusion	exclusion	NOUN
bptjm-33	171	20	of	of	ADP
bptjm-33	171	21	exons	exon	NOUN
bptjm-33	171	22	2,3	2,3	NUM
bptjm-33	171	23	,	,	PUNCT
bptjm-33	171	24	and	and	CCONJ
bptjm-33	171	25	10	10	NUM
bptjm-33	171	26	.	.	PUNCT
bptjm-33	172	1	another	another	DET
bptjm-33	172	2	study	study	NOUN
bptjm-33	172	3	aimed	aim	VERB
bptjm-33	172	4	to	to	PART
bptjm-33	172	5	uncover	uncover	VERB
bptjm-33	172	6	the	the	DET
bptjm-33	172	7	role	role	NOUN
bptjm-33	172	8	of	of	ADP
bptjm-33	172	9	mirnas	mirna	NOUN
bptjm-33	172	10	in	in	ADP
bptjm-33	172	11	tau	tau	PROPN
bptjm-33	172	12	metabolism	metabolism	NOUN
bptjm-33	172	13	identified	identify	VERB
bptjm-33	172	14	mir-16	mir-16	PROPN
bptjm-33	172	15	and	and	CCONJ
bptjm-33	172	16	mir132	mir132	PROPN
bptjm-33	172	17	as	as	ADP
bptjm-33	172	18	putative	putative	ADJ
bptjm-33	172	19	endogenous	endogenous	ADJ
bptjm-33	172	20	regulators	regulator	NOUN
bptjm-33	172	21	of	of	ADP
bptjm-33	172	22	neuronal	neuronal	ADJ
bptjm-33	172	23	p	p	PROPN
bptjm-33	172	24	-	-	PUNCT
bptjm-33	172	25	tau	tau	PROPN
bptjm-33	172	26	and	and	CCONJ
bptjm-33	172	27	exon	exon	NOUN
bptjm-33	172	28	10	10	NUM
bptjm-33	172	29	splicing	splicing	NOUN
bptjm-33	172	30	,	,	PUNCT
bptjm-33	172	31	respectively	respectively	ADV
bptjm-33	172	32	,	,	PUNCT
bptjm-33	172	33	and	and	CCONJ
bptjm-33	172	34	mutations	mutation	NOUN
bptjm-33	172	35	in	in	ADP
bptjm-33	172	36	tau	tau	PROPN
bptjm-33	172	37	exon	exon	NOUN
bptjm-33	172	38	10	10	NUM
bptjm-33	172	39	have	have	AUX
bptjm-33	172	40	been	be	AUX
bptjm-33	172	41	associated	associate	VERB
bptjm-33	172	42	with	with	ADP
bptjm-33	172	43	neurodegeneration	neurodegeneration	NOUN
bptjm-33	172	44	and	and	CCONJ
bptjm-33	172	45	dementia	dementia	NOUN
bptjm-33	172	46	in	in	ADP
bptjm-33	172	47	the	the	DET
bptjm-33	172	48	adulthood31	adulthood31	NOUN
bptjm-33	172	49	.	.	PUNCT
bptjm-33	173	1	overall	overall	ADJ
bptjm-33	173	2	,	,	PUNCT
bptjm-33	173	3	altered	altered	ADJ
bptjm-33	173	4	levels	level	NOUN
bptjm-33	173	5	of	of	ADP
bptjm-33	173	6	mir-16	mir-16	PROPN
bptjm-33	173	7	and	and	CCONJ
bptjm-33	173	8	mir-132	mir-132	PROPN
bptjm-33	173	9	were	be	AUX
bptjm-33	173	10	associated	associate	VERB
bptjm-33	173	11	with	with	ADP
bptjm-33	173	12	tau	tau	PROPN
bptjm-33	173	13	pathology	pathology	NOUN
bptjm-33	173	14	in	in	ADP
bptjm-33	173	15	human	human	ADJ
bptjm-33	173	16	neurodegenerative	neurodegenerative	ADJ
bptjm-33	173	17	disorders31	disorders31	NOUN
bptjm-33	173	18	.	.	PUNCT
bptjm-33	174	1	6.3	6.3	NUM
bptjm-33	174	2	.	.	PUNCT
bptjm-33	174	3	amyloid	amyloid	NOUN
bptjm-33	174	4	-	-	PUNCT
bptjm-33	174	5	β	β	X
bptjm-33	174	6	(	(	PUNCT
bptjm-33	174	7	aβ	aβ	NOUN
bptjm-33	174	8	)	)	PUNCT
bptjm-33	174	9	peptides	peptide	NOUN
bptjm-33	174	10	and	and	CCONJ
bptjm-33	174	11	bace-1	bace-1	NUM
bptjm-33	174	12	ad	ad	NOUN
bptjm-33	174	13	has	have	AUX
bptjm-33	174	14	been	be	AUX
bptjm-33	174	15	associated	associate	VERB
bptjm-33	174	16	with	with	ADP
bptjm-33	174	17	increased	increase	VERB
bptjm-33	174	18	production	production	NOUN
bptjm-33	174	19	of	of	ADP
bptjm-33	174	20	amyloid	amyloid	NOUN
bptjm-33	174	21	-	-	PUNCT
bptjm-33	174	22	β	β	X
bptjm-33	174	23	(	(	PUNCT
bptjm-33	174	24	aβ	aβ	NOUN
bptjm-33	174	25	)	)	PUNCT
bptjm-33	174	26	peptides	peptide	NOUN
bptjm-33	174	27	and	and	CCONJ
bptjm-33	174	28	impaired	impaired	ADJ
bptjm-33	174	29	function	function	NOUN
bptjm-33	174	30	of	of	ADP
bptjm-33	174	31	its	its	PRON
bptjm-33	174	32	clearance	clearance	NOUN
bptjm-33	174	33	.	.	PUNCT
bptjm-33	175	1	mirnas	mirna	NOUN
bptjm-33	175	2	targeting	target	VERB
bptjm-33	175	3	the	the	DET
bptjm-33	175	4	key	key	ADJ
bptjm-33	175	5	proteins	protein	NOUN
bptjm-33	175	6	of	of	ADP
bptjm-33	175	7	the	the	DET
bptjm-33	175	8	amyloidogenic	amyloidogenic	ADJ
bptjm-33	175	9	pathway	pathway	NOUN
bptjm-33	175	10	are	be	AUX
bptjm-33	175	11	of	of	ADP
bptjm-33	175	12	interest	interest	NOUN
bptjm-33	175	13	to	to	ADP
bptjm-33	175	14	current	current	ADJ
bptjm-33	175	15	research	research	NOUN
bptjm-33	175	16	on	on	ADP
bptjm-33	175	17	ad	ad	NOUN
bptjm-33	175	18	therapeutics	therapeutic	NOUN
bptjm-33	175	19	.	.	PUNCT
bptjm-33	176	1	a	a	DET
bptjm-33	176	2	study	study	NOUN
bptjm-33	176	3	has	have	AUX
bptjm-33	176	4	shown	show	VERB
bptjm-33	176	5	that	that	SCONJ
bptjm-33	176	6	mir-31	mir-31	NOUN
bptjm-33	176	7	,	,	PUNCT
bptjm-33	176	8	previously	previously	ADV
bptjm-33	176	9	found	find	VERB
bptjm-33	176	10	to	to	PART
bptjm-33	176	11	be	be	AUX
bptjm-33	176	12	decreased	decrease	VERB
bptjm-33	176	13	in	in	ADP
bptjm-33	176	14	ad	ad	NOUN
bptjm-33	176	15	patients	patient	NOUN
bptjm-33	176	16	,	,	PUNCT
bptjm-33	176	17	suggests	suggest	VERB
bptjm-33	176	18	that	that	SCONJ
bptjm-33	176	19	mir-31	mir-31	NOUN
bptjm-33	176	20	-	-	PUNCT
bptjm-33	176	21	mediated	mediate	VERB
bptjm-33	176	22	modulation	modulation	NOUN
bptjm-33	176	23	of	of	ADP
bptjm-33	176	24	app	app	PROPN
bptjm-33	176	25	and	and	CCONJ
bptjm-33	176	26	bace1	bace1	NOUN
bptjm-33	176	27	can	can	AUX
bptjm-33	176	28	become	become	VERB
bptjm-33	176	29	a	a	DET
bptjm-33	176	30	therapeutic	therapeutic	ADJ
bptjm-33	176	31	option	option	NOUN
bptjm-33	176	32	in	in	ADP
bptjm-33	176	33	the	the	DET
bptjm-33	176	34	treatment	treatment	NOUN
bptjm-33	176	35	of	of	ADP
bptjm-33	176	36	ad	ad	NOUN
bptjm-33	176	37	.	.	PUNCT
bptjm-33	177	1	mir-31	mir-31	NOUN
bptjm-33	177	2	upregulation	upregulation	NOUN
bptjm-33	177	3	in	in	ADP
bptjm-33	177	4	17	17	NUM
bptjm-33	177	5	-	-	PUNCT
bptjm-33	177	6	month	month	NOUN
bptjm-33	177	7	-	-	PUNCT
bptjm-33	177	8	old	old	ADJ
bptjm-33	177	9	ad	ad	NOUN
bptjm-33	177	10	triple	triple	ADJ
bptjm-33	177	11	-	-	PUNCT
bptjm-33	177	12	transgenic	transgenic	NOUN
bptjm-33	177	13	(	(	PUNCT
bptjm-33	177	14	3xtg	3xtg	ADJ
bptjm-33	177	15	-	-	PUNCT
bptjm-33	177	16	ad	ad	NOUN
bptjm-33	177	17	)	)	PUNCT
bptjm-33	177	18	female	female	ADJ
bptjm-33	177	19	mice	mouse	NOUN
bptjm-33	177	20	simultaneously	simultaneously	ADV
bptjm-33	177	21	reduced	reduce	VERB
bptjm-33	177	22	app	app	NOUN
bptjm-33	177	23	and	and	CCONJ
bptjm-33	177	24	bace-1	bace-1	PROPN
bptjm-33	177	25	mrna	mrna	PROPN
bptjm-33	177	26	levels	level	NOUN
bptjm-33	177	27	in	in	ADP
bptjm-33	177	28	the	the	DET
bptjm-33	177	29	hippocampus	hippocampus	NOUN
bptjm-33	177	30	,	,	PUNCT
bptjm-33	177	31	significantly	significantly	ADV
bptjm-33	177	32	ameliorated	ameliorate	VERB
bptjm-33	177	33	deficits	deficit	NOUN
bptjm-33	177	34	in	in	ADP
bptjm-33	177	35	short	short	ADJ
bptjm-33	177	36	and	and	CCONJ
bptjm-33	177	37	long	long	ADJ
bptjm-33	177	38	-	-	PUNCT
bptjm-33	177	39	term	term	NOUN
bptjm-33	177	40	berkeley	berkeley	PROPN
bptjm-33	177	41	pharma	pharma	PROPN
bptjm-33	177	42	tech	tech	NOUN
bptjm-33	177	43	journal	journal	NOUN
bptjm-33	177	44	of	of	ADP
bptjm-33	177	45	medicine	medicine	NOUN
bptjm-33	177	46	|	|	ADV
bptjm-33	177	47	62	62	NUM
bptjm-33	177	48	memory	memory	NOUN
bptjm-33	177	49	,	,	PUNCT
bptjm-33	177	50	and	and	CCONJ
bptjm-33	177	51	reduced	reduce	VERB
bptjm-33	177	52	anxiety	anxiety	NOUN
bptjm-33	177	53	and	and	CCONJ
bptjm-33	177	54	cognitive	cognitive	ADJ
bptjm-33	177	55	inflexibility	inflexibility	NOUN
bptjm-33	177	56	.	.	PUNCT
bptjm-33	178	1	in	in	ADP
bptjm-33	178	2	addition	addition	NOUN
bptjm-33	178	3	,	,	PUNCT
bptjm-33	178	4	lentiviral	lentiviral	ADJ
bptjm-33	178	5	-	-	PUNCT
bptjm-33	178	6	mediated	mediate	VERB
bptjm-33	178	7	mir-31	mir-31	NOUN
bptjm-33	178	8	expression	expression	NOUN
bptjm-33	178	9	significantly	significantly	ADV
bptjm-33	178	10	reduced	reduce	VERB
bptjm-33	178	11	ad	ad	NOUN
bptjm-33	178	12	neuropathology	neuropathology	NOUN
bptjm-33	178	13	in	in	ADP
bptjm-33	178	14	the	the	DET
bptjm-33	178	15	mouse	mouse	NOUN
bptjm-33	178	16	mode	mode	NOUN
bptjm-33	178	17	with	with	ADP
bptjm-33	178	18	a	a	DET
bptjm-33	178	19	reduced	reduce	VERB
bptjm-33	178	20	aβ	aβ	NOUN
bptjm-33	178	21	accumulation	accumulation	NOUN
bptjm-33	178	22	in	in	ADP
bptjm-33	178	23	both	both	CCONJ
bptjm-33	178	24	the	the	DET
bptjm-33	178	25	hippocampus	hippocampus	NOUN
bptjm-33	178	26	and	and	CCONJ
bptjm-33	178	27	subiculum26	subiculum26	NOUN
bptjm-33	178	28	.	.	PUNCT
bptjm-33	179	1	mirnas	mirna	NOUN
bptjm-33	179	2	typically	typically	ADV
bptjm-33	179	3	inhibit	inhibit	VERB
bptjm-33	179	4	protein	protein	NOUN
bptjm-33	179	5	expression	expression	NOUN
bptjm-33	179	6	by	by	ADP
bptjm-33	179	7	binding	bind	VERB
bptjm-33	179	8	to	to	ADP
bptjm-33	179	9	its	its	PRON
bptjm-33	179	10	complement	complement	NOUN
bptjm-33	179	11	mrnas	mrna	NOUN
bptjm-33	179	12	’	'	PUNCT
bptjm-33	179	13	3′-untranslated	3′-untranslated	ADJ
bptjm-33	179	14	regions	region	NOUN
bptjm-33	179	15	(	(	PUNCT
bptjm-33	179	16	3′-utr	3′-utr	NUM
bptjm-33	179	17	)	)	PUNCT
bptjm-33	179	18	in	in	ADP
bptjm-33	179	19	a	a	DET
bptjm-33	179	20	cell	cell	NOUN
bptjm-33	179	21	-	-	PUNCT
bptjm-33	179	22	specific	specific	ADJ
bptjm-33	179	23	manner	manner	NOUN
bptjm-33	179	24	.	.	PUNCT
bptjm-33	180	1	however	however	ADV
bptjm-33	180	2	,	,	PUNCT
bptjm-33	180	3	the	the	DET
bptjm-33	180	4	mechanisms	mechanism	NOUN
bptjm-33	180	5	of	of	ADP
bptjm-33	180	6	the	the	DET
bptjm-33	180	7	variation	variation	NOUN
bptjm-33	180	8	of	of	ADP
bptjm-33	180	9	mirna	mirna	NOUN
bptjm-33	180	10	activity	activity	NOUN
bptjm-33	180	11	remain	remain	VERB
bptjm-33	180	12	unknown	unknown	ADJ
bptjm-33	180	13	.	.	PUNCT
bptjm-33	181	1	another	another	DET
bptjm-33	181	2	study	study	NOUN
bptjm-33	181	3	demonstrated	demonstrate	VERB
bptjm-33	181	4	the	the	DET
bptjm-33	181	5	differing	differ	VERB
bptjm-33	181	6	effects	effect	NOUN
bptjm-33	181	7	of	of	ADP
bptjm-33	181	8	treatment	treatment	NOUN
bptjm-33	181	9	of	of	ADP
bptjm-33	181	10	mir-298	mir-298	NOUN
bptjm-33	181	11	reduced	reduce	VERB
bptjm-33	181	12	native	native	ADJ
bptjm-33	181	13	app	app	NOUN
bptjm-33	181	14	and	and	CCONJ
bptjm-33	181	15	bace-1	bace-1	PROPN
bptjm-33	181	16	translation	translation	NOUN
bptjm-33	181	17	levels	level	NOUN
bptjm-33	181	18	in	in	ADP
bptjm-33	181	19	astrocytic	astrocytic	ADJ
bptjm-33	181	20	but	but	CCONJ
bptjm-33	181	21	not	not	PART
bptjm-33	181	22	in	in	ADP
bptjm-33	181	23	a	a	DET
bptjm-33	181	24	neuron	neuron	NOUN
bptjm-33	181	25	-	-	PUNCT
bptjm-33	181	26	like	like	ADJ
bptjm-33	181	27	cell	cell	NOUN
bptjm-33	181	28	line	line	NOUN
bptjm-33	181	29	.	.	PUNCT
bptjm-33	182	1	the	the	DET
bptjm-33	182	2	variation	variation	NOUN
bptjm-33	182	3	in	in	ADP
bptjm-33	182	4	its	its	PRON
bptjm-33	182	5	effects	effect	NOUN
bptjm-33	182	6	on	on	ADP
bptjm-33	182	7	app-3’-utr	app-3’-utr	NOUN
bptjm-33	182	8	activity	activity	NOUN
bptjm-33	182	9	and	and	CCONJ
bptjm-33	182	10	native	native	ADJ
bptjm-33	182	11	protein	protein	NOUN
bptjm-33	182	12	levels	level	NOUN
bptjm-33	182	13	are	be	AUX
bptjm-33	182	14	according	accord	VERB
bptjm-33	182	15	to	to	ADP
bptjm-33	182	16	cell	cell	NOUN
bptjm-33	182	17	type	type	NOUN
bptjm-33	182	18	and	and	CCONJ
bptjm-33	182	19	3’-utr	3’-utr	NUM
bptjm-33	182	20	specificity	specificity	NOUN
bptjm-33	182	21	.	.	PUNCT
bptjm-33	183	1	researchers	researcher	NOUN
bptjm-33	183	2	postulated	postulate	VERB
bptjm-33	183	3	that	that	SCONJ
bptjm-33	183	4	naturally	naturally	ADV
bptjm-33	183	5	occurring	occur	VERB
bptjm-33	183	6	variations	variation	NOUN
bptjm-33	183	7	in	in	ADP
bptjm-33	183	8	the	the	DET
bptjm-33	183	9	length	length	NOUN
bptjm-33	183	10	of	of	ADP
bptjm-33	183	11	app	app	NOUN
bptjm-33	183	12	3	3	NUM
bptjm-33	183	13	’	'	PUNCT
bptjm-33	183	14	utr	utr	NOUN
bptjm-33	183	15	could	could	AUX
bptjm-33	183	16	account	account	VERB
bptjm-33	183	17	for	for	ADP
bptjm-33	183	18	mir-298	mir-298	NOUN
bptjm-33	183	19	cell	cell	NOUN
bptjm-33	183	20	-	-	PUNCT
bptjm-33	183	21	specificity	specificity	NOUN
bptjm-33	183	22	.	.	PUNCT
bptjm-33	184	1	such	such	ADJ
bptjm-33	184	2	novel	novel	ADJ
bptjm-33	184	3	mir-298	mir-298	NOUN
bptjm-33	184	4	involvement	involvement	NOUN
bptjm-33	184	5	in	in	ADP
bptjm-33	184	6	ad	ad	NOUN
bptjm-33	184	7	provides	provide	VERB
bptjm-33	184	8	valuable	valuable	ADJ
bptjm-33	184	9	insight	insight	NOUN
bptjm-33	184	10	into	into	ADP
bptjm-33	184	11	the	the	DET
bptjm-33	184	12	clinically	clinically	ADV
bptjm-33	184	13	relevant	relevant	ADJ
bptjm-33	184	14	research	research	NOUN
bptjm-33	184	15	on	on	ADP
bptjm-33	184	16	tailoring	tailor	VERB
bptjm-33	184	17	mirna	mirna	NOUN
bptjm-33	184	18	’s	’s	PART
bptjm-33	184	19	effect	effect	NOUN
bptjm-33	184	20	to	to	ADP
bptjm-33	184	21	a	a	DET
bptjm-33	184	22	specific	specific	ADJ
bptjm-33	184	23	cell	cell	NOUN
bptjm-33	184	24	type	type	NOUN
bptjm-33	184	25	in	in	ADP
bptjm-33	184	26	the	the	DET
bptjm-33	184	27	treatment	treatment	NOUN
bptjm-33	184	28	of	of	ADP
bptjm-33	184	29	ad32	ad32	PROPN
bptjm-33	184	30	.	.	PROPN
bptjm-33	185	1	6.4	6.4	NUM
bptjm-33	185	2	.	.	PUNCT
bptjm-33	186	1	apolipoprotein	apolipoprotein	PROPN
bptjm-33	186	2	e	e	PROPN
bptjm-33	186	3	(	(	PUNCT
bptjm-33	186	4	apoe4	apoe4	PROPN
bptjm-33	186	5	)	)	PUNCT
bptjm-33	186	6	a	a	DET
bptjm-33	186	7	study	study	NOUN
bptjm-33	186	8	identified	identify	VERB
bptjm-33	186	9	the	the	DET
bptjm-33	186	10	involvement	involvement	NOUN
bptjm-33	186	11	of	of	ADP
bptjm-33	186	12	mir-195	mir-195	NOUN
bptjm-33	186	13	in	in	ADP
bptjm-33	186	14	apoe4	apoe4	PROPN
bptjm-33	186	15	-	-	PUNCT
bptjm-33	186	16	associated	associated	ADJ
bptjm-33	186	17	pathology	pathology	NOUN
bptjm-33	186	18	in	in	ADP
bptjm-33	186	19	ad	ad	NOUN
bptjm-33	186	20	disease	disease	NOUN
bptjm-33	186	21	progression	progression	NOUN
bptjm-33	186	22	.	.	PUNCT
bptjm-33	187	1	results	result	NOUN
bptjm-33	187	2	demonstrated	demonstrate	VERB
bptjm-33	187	3	that	that	SCONJ
bptjm-33	187	4	reduced	reduced	ADJ
bptjm-33	187	5	levels	level	NOUN
bptjm-33	187	6	of	of	ADP
bptjm-33	187	7	mir-195	mir-195	NOUN
bptjm-33	187	8	in	in	ADP
bptjm-33	187	9	the	the	DET
bptjm-33	187	10	ad	ad	NOUN
bptjm-33	187	11	brain	brain	NOUN
bptjm-33	187	12	correlated	correlate	VERB
bptjm-33	187	13	with	with	ADP
bptjm-33	187	14	early	early	ADJ
bptjm-33	187	15	disease	disease	NOUN
bptjm-33	187	16	progression	progression	NOUN
bptjm-33	187	17	but	but	CCONJ
bptjm-33	187	18	not	not	PART
bptjm-33	187	19	advanced	advanced	ADJ
bptjm-33	187	20	stages	stage	NOUN
bptjm-33	187	21	of	of	ADP
bptjm-33	187	22	ad	ad	NOUN
bptjm-33	187	23	.	.	PUNCT
bptjm-33	188	1	moreover	moreover	ADV
bptjm-33	188	2	,	,	PUNCT
bptjm-33	188	3	it	it	PRON
bptjm-33	188	4	has	have	AUX
bptjm-33	188	5	been	be	AUX
bptjm-33	188	6	noted	note	VERB
bptjm-33	188	7	that	that	SCONJ
bptjm-33	188	8	the	the	DET
bptjm-33	188	9	apoe4	apoe4	PROPN
bptjm-33	188	10	genotype	genotype	NOUN
bptjm-33	188	11	accelerated	accelerate	VERB
bptjm-33	188	12	mir-195	mir-195	NOUN
bptjm-33	188	13	reduction	reduction	NOUN
bptjm-33	188	14	,	,	PUNCT
bptjm-33	188	15	leading	lead	VERB
bptjm-33	188	16	to	to	ADP
bptjm-33	188	17	increased	increase	VERB
bptjm-33	188	18	tau	tau	PROPN
bptjm-33	188	19	pathology	pathology	NOUN
bptjm-33	188	20	and	and	CCONJ
bptjm-33	188	21	cognitive	cognitive	ADJ
bptjm-33	188	22	decline33	decline33	NOUN
bptjm-33	188	23	.	.	PUNCT
bptjm-33	189	1	in	in	ADP
bptjm-33	189	2	addition	addition	NOUN
bptjm-33	189	3	,	,	PUNCT
bptjm-33	189	4	mir-195	mir-195	ADJ
bptjm-33	189	5	overexpression	overexpression	NOUN
bptjm-33	189	6	reduced	reduce	VERB
bptjm-33	189	7	the	the	DET
bptjm-33	189	8	expression	expression	NOUN
bptjm-33	189	9	of	of	ADP
bptjm-33	189	10	its	its	PRON
bptjm-33	189	11	target	target	NOUN
bptjm-33	189	12	,	,	PUNCT
bptjm-33	189	13	synaptojanin1	synaptojanin1	NOUN
bptjm-33	189	14	(	(	PUNCT
bptjm-33	189	15	synj	synj	NOUN
bptjm-33	189	16	1	1	NUM
bptjm-33	189	17	)	)	PUNCT
bptjm-33	189	18	,	,	PUNCT
bptjm-33	189	19	a	a	DET
bptjm-33	189	20	brain	brain	NOUN
bptjm-33	189	21	pip2	pip2	NOUN
bptjm-33	189	22	-	-	PUNCT
bptjm-33	189	23	degrading	degrade	VERB
bptjm-33	189	24	enzyme	enzyme	NOUN
bptjm-33	189	25	that	that	PRON
bptjm-33	189	26	plays	play	VERB
bptjm-33	189	27	an	an	DET
bptjm-33	189	28	important	important	ADJ
bptjm-33	189	29	functional	functional	ADJ
bptjm-33	189	30	role	role	NOUN
bptjm-33	189	31	in	in	ADP
bptjm-33	189	32	ad	ad	NOUN
bptjm-33	189	33	pathogenesis	pathogenesis	NOUN
bptjm-33	189	34	in	in	ADP
bptjm-33	189	35	mice	mouse	NOUN
bptjm-33	189	36	models	model	NOUN
bptjm-33	189	37	.	.	PUNCT
bptjm-33	190	1	for	for	ADP
bptjm-33	190	2	example	example	NOUN
bptjm-33	190	3	,	,	PUNCT
bptjm-33	190	4	reduced	reduced	ADJ
bptjm-33	190	5	synj	synj	NOUN
bptjm-33	190	6	1	1	NUM
bptjm-33	190	7	expression	expression	NOUN
bptjm-33	190	8	is	be	AUX
bptjm-33	190	9	associated	associate	VERB
bptjm-33	190	10	with	with	ADP
bptjm-33	190	11	faster	fast	ADJ
bptjm-33	190	12	aβ	aβ	PRON
bptjm-33	190	13	clearance	clearance	NOUN
bptjm-33	190	14	via	via	ADP
bptjm-33	190	15	the	the	DET
bptjm-33	190	16	lysosomal	lysosomal	ADJ
bptjm-33	190	17	degradation	degradation	NOUN
bptjm-33	190	18	pathway	pathway	NOUN
bptjm-33	190	19	,	,	PUNCT
bptjm-33	190	20	ameliorating	ameliorate	VERB
bptjm-33	190	21	elevated	elevated	ADJ
bptjm-33	190	22	tau	tau	PROPN
bptjm-33	190	23	hyperphosphorylation	hyperphosphorylation	NOUN
bptjm-33	190	24	levels	level	NOUN
bptjm-33	190	25	and	and	CCONJ
bptjm-33	190	26	rescuing	rescue	VERB
bptjm-33	190	27	apoe4	apoe4	ADJ
bptjm-33	190	28	-	-	PUNCT
bptjm-33	190	29	associated	associated	ADJ
bptjm-33	190	30	neuronal	neuronal	ADJ
bptjm-33	190	31	impairment33	impairment33	NOUN
bptjm-33	190	32	.	.	PUNCT
bptjm-33	191	1	ongoing	ongoing	ADJ
bptjm-33	191	2	research	research	NOUN
bptjm-33	191	3	aims	aim	VERB
bptjm-33	191	4	to	to	PART
bptjm-33	191	5	uncover	uncover	VERB
bptjm-33	191	6	specific	specific	ADJ
bptjm-33	191	7	mechanisms	mechanism	NOUN
bptjm-33	191	8	of	of	ADP
bptjm-33	191	9	mir-195	mir-195	PROPN
bptjm-33	191	10	involvement	involvement	NOUN
bptjm-33	191	11	targeted	target	VERB
bptjm-33	191	12	at	at	ADP
bptjm-33	191	13	apoe4	apoe4	PROPN
bptjm-33	191	14	for	for	ADP
bptjm-33	191	15	future	future	ADJ
bptjm-33	191	16	therapeutic	therapeutic	ADJ
bptjm-33	191	17	purposes	purpose	NOUN
bptjm-33	191	18	.	.	PUNCT
bptjm-33	192	1	7	7	X
bptjm-33	192	2	.	.	X
bptjm-33	192	3	practical	practical	ADJ
bptjm-33	192	4	/	/	SYM
bptjm-33	192	5	clinical	clinical	ADJ
bptjm-33	192	6	applications	application	NOUN
bptjm-33	192	7	and	and	CCONJ
bptjm-33	192	8	feasibility	feasibility	NOUN
bptjm-33	192	9	7.1	7.1	NUM
bptjm-33	192	10	.	.	PUNCT
bptjm-33	193	1	mirna	mirna	PROPN
bptjm-33	193	2	benefits	benefit	NOUN
bptjm-33	193	3	this	this	DET
bptjm-33	193	4	novel	novel	ADJ
bptjm-33	193	5	therapeutic	therapeutic	ADJ
bptjm-33	193	6	has	have	AUX
bptjm-33	193	7	shown	show	VERB
bptjm-33	193	8	promising	promising	ADJ
bptjm-33	193	9	results	result	NOUN
bptjm-33	193	10	in	in	ADP
bptjm-33	193	11	research	research	NOUN
bptjm-33	193	12	and	and	CCONJ
bptjm-33	193	13	laboratory	laboratory	NOUN
bptjm-33	193	14	environments	environment	NOUN
bptjm-33	193	15	.	.	PUNCT
bptjm-33	194	1	but	but	CCONJ
bptjm-33	194	2	how	how	SCONJ
bptjm-33	194	3	are	be	AUX
bptjm-33	194	4	these	these	DET
bptjm-33	194	5	principles	principle	NOUN
bptjm-33	194	6	and	and	CCONJ
bptjm-33	194	7	tools	tool	NOUN
bptjm-33	194	8	translated	translate	VERB
bptjm-33	194	9	and	and	CCONJ
bptjm-33	194	10	applied	apply	VERB
bptjm-33	194	11	to	to	ADP
bptjm-33	194	12	the	the	DET
bptjm-33	194	13	real	real	ADJ
bptjm-33	194	14	world	world	NOUN
bptjm-33	194	15	?	?	PUNCT
bptjm-33	195	1	the	the	DET
bptjm-33	195	2	basis	basis	NOUN
bptjm-33	195	3	of	of	ADP
bptjm-33	195	4	the	the	DET
bptjm-33	195	5	therapeutic	therapeutic	NOUN
bptjm-33	195	6	is	be	AUX
bptjm-33	195	7	the	the	DET
bptjm-33	195	8	molecule	molecule	NOUN
bptjm-33	195	9	berkeley	berkeley	PROPN
bptjm-33	195	10	pharma	pharma	PROPN
bptjm-33	195	11	tech	tech	NOUN
bptjm-33	195	12	journal	journal	NOUN
bptjm-33	195	13	of	of	ADP
bptjm-33	195	14	medicine	medicine	NOUN
bptjm-33	195	15	|	|	ADV
bptjm-33	195	16	63	63	NUM
bptjm-33	195	17	mirna	mirna	NOUN
bptjm-33	195	18	.	.	PUNCT
bptjm-33	196	1	compared	compare	VERB
bptjm-33	196	2	to	to	ADP
bptjm-33	196	3	most	most	ADJ
bptjm-33	196	4	nucleic	nucleic	ADJ
bptjm-33	196	5	acids	acid	NOUN
bptjm-33	196	6	,	,	PUNCT
bptjm-33	196	7	mirna	mirna	PROPN
bptjm-33	196	8	is	be	AUX
bptjm-33	196	9	a	a	DET
bptjm-33	196	10	highly	highly	ADV
bptjm-33	196	11	stable	stable	ADJ
bptjm-33	196	12	molecule	molecule	NOUN
bptjm-33	196	13	,	,	PUNCT
bptjm-33	196	14	therefore	therefore	ADV
bptjm-33	196	15	“	"	PUNCT
bptjm-33	196	16	surviving	surviving	NOUN
bptjm-33	196	17	”	"	PUNCT
bptjm-33	196	18	in	in	ADP
bptjm-33	196	19	bodily	bodily	ADJ
bptjm-33	196	20	fluids	fluid	NOUN
bptjm-33	196	21	,	,	PUNCT
bptjm-33	196	22	such	such	ADJ
bptjm-33	196	23	as	as	ADP
bptjm-33	196	24	the	the	DET
bptjm-33	196	25	csf	csf	NOUN
bptjm-33	196	26	,	,	PUNCT
bptjm-33	196	27	when	when	SCONJ
bptjm-33	196	28	observing	observe	VERB
bptjm-33	196	29	brain	brain	NOUN
bptjm-33	196	30	diseases	disease	NOUN
bptjm-33	196	31	such	such	ADJ
bptjm-33	196	32	as	as	ADP
bptjm-33	196	33	ad34	ad34	PROPN
bptjm-33	196	34	.	.	PUNCT
bptjm-33	197	1	this	this	DET
bptjm-33	197	2	stability	stability	NOUN
bptjm-33	197	3	allows	allow	VERB
bptjm-33	197	4	for	for	ADP
bptjm-33	197	5	an	an	DET
bptjm-33	197	6	easier	easy	ADJ
bptjm-33	197	7	analysis	analysis	NOUN
bptjm-33	197	8	,	,	PUNCT
bptjm-33	197	9	making	make	VERB
bptjm-33	197	10	it	it	PRON
bptjm-33	197	11	ideal	ideal	ADJ
bptjm-33	197	12	for	for	ADP
bptjm-33	197	13	clinical	clinical	ADJ
bptjm-33	197	14	settings	setting	NOUN
bptjm-33	197	15	.	.	PUNCT
bptjm-33	198	1	furthermore	furthermore	ADV
bptjm-33	198	2	,	,	PUNCT
bptjm-33	198	3	it	it	PRON
bptjm-33	198	4	has	have	AUX
bptjm-33	198	5	been	be	AUX
bptjm-33	198	6	shown	show	VERB
bptjm-33	198	7	that	that	SCONJ
bptjm-33	198	8	mirna	mirna	PROPN
bptjm-33	198	9	is	be	AUX
bptjm-33	198	10	better	well	ADV
bptjm-33	198	11	amplified	amplify	VERB
bptjm-33	198	12	in	in	ADP
bptjm-33	198	13	pcr	pcr	ADJ
bptjm-33	198	14	treatments	treatment	NOUN
bptjm-33	198	15	which	which	PRON
bptjm-33	198	16	is	be	AUX
bptjm-33	198	17	a	a	DET
bptjm-33	198	18	very	very	ADV
bptjm-33	198	19	commonly	commonly	ADV
bptjm-33	198	20	used	use	VERB
bptjm-33	198	21	method	method	NOUN
bptjm-33	198	22	in	in	ADP
bptjm-33	198	23	the	the	DET
bptjm-33	198	24	scientific	scientific	ADJ
bptjm-33	198	25	and	and	CCONJ
bptjm-33	198	26	medical	medical	ADJ
bptjm-33	198	27	field34	field34	NOUN
bptjm-33	198	28	.	.	PUNCT
bptjm-33	199	1	another	another	DET
bptjm-33	199	2	benefit	benefit	NOUN
bptjm-33	199	3	of	of	ADP
bptjm-33	199	4	the	the	DET
bptjm-33	199	5	mirna	mirna	NOUN
bptjm-33	199	6	is	be	AUX
bptjm-33	199	7	that	that	SCONJ
bptjm-33	199	8	they	they	PRON
bptjm-33	199	9	constrain	constrain	VERB
bptjm-33	199	10	sequences	sequence	NOUN
bptjm-33	199	11	that	that	PRON
bptjm-33	199	12	create	create	VERB
bptjm-33	199	13	molecules	molecule	NOUN
bptjm-33	199	14	that	that	PRON
bptjm-33	199	15	have	have	AUX
bptjm-33	199	16	been	be	AUX
bptjm-33	199	17	proven	prove	VERB
bptjm-33	199	18	to	to	PART
bptjm-33	199	19	be	be	AUX
bptjm-33	199	20	directly	directly	ADV
bptjm-33	199	21	related	relate	VERB
bptjm-33	199	22	to	to	ADP
bptjm-33	199	23	ad	ad	NOUN
bptjm-33	199	24	.	.	PUNCT
bptjm-33	200	1	more	more	ADV
bptjm-33	200	2	specifically	specifically	ADV
bptjm-33	200	3	,	,	PUNCT
bptjm-33	200	4	mirnas	mirna	NOUN
bptjm-33	200	5	are	be	AUX
bptjm-33	200	6	known	know	VERB
bptjm-33	200	7	to	to	PART
bptjm-33	200	8	regulate	regulate	VERB
bptjm-33	200	9	the	the	DET
bptjm-33	200	10	production	production	NOUN
bptjm-33	200	11	of	of	ADP
bptjm-33	200	12	genes	gene	NOUN
bptjm-33	200	13	like	like	ADP
bptjm-33	200	14	app	app	NOUN
bptjm-33	200	15	and	and	CCONJ
bptjm-33	200	16	the	the	DET
bptjm-33	200	17	bace-1	bace-1	PROPN
bptjm-33	200	18	,	,	PUNCT
bptjm-33	200	19	which	which	PRON
bptjm-33	200	20	affects	affect	VERB
bptjm-33	200	21	the	the	DET
bptjm-33	200	22	production	production	NOUN
bptjm-33	200	23	of	of	ADP
bptjm-33	200	24	aβ32,34	aβ32,34	PROPN
bptjm-33	200	25	.	.	PUNCT
bptjm-33	201	1	for	for	ADP
bptjm-33	201	2	example	example	NOUN
bptjm-33	201	3	,	,	PUNCT
bptjm-33	201	4	mir-340	mir-340	NOUN
bptjm-33	201	5	can	can	AUX
bptjm-33	201	6	be	be	AUX
bptjm-33	201	7	used	use	VERB
bptjm-33	201	8	to	to	PART
bptjm-33	201	9	alleviate	alleviate	VERB
bptjm-33	201	10	ad	ad	NOUN
bptjm-33	201	11	by	by	ADP
bptjm-33	201	12	targeting	target	VERB
bptjm-33	201	13	the	the	DET
bptjm-33	201	14	aβ	aβ	NOUN
bptjm-33	201	15	and	and	CCONJ
bptjm-33	201	16	mir342–3p	mir342–3p	NOUN
bptjm-33	201	17	was	be	AUX
bptjm-33	201	18	shown	show	VERB
bptjm-33	201	19	to	to	PART
bptjm-33	201	20	be	be	AUX
bptjm-33	201	21	in	in	ADP
bptjm-33	201	22	higher	high	ADJ
bptjm-33	201	23	concentrations	concentration	NOUN
bptjm-33	201	24	in	in	ADP
bptjm-33	201	25	ad	ad	NOUN
bptjm-33	201	26	patients	patient	NOUN
bptjm-33	201	27	,	,	PUNCT
bptjm-33	201	28	which	which	PRON
bptjm-33	201	29	increased	increase	VERB
bptjm-33	201	30	the	the	DET
bptjm-33	201	31	stress	stress	NOUN
bptjm-33	201	32	kinase	kinase	PROPN
bptjm-33	201	33	c	c	PROPN
bptjm-33	201	34	-	-	PUNCT
bptjm-33	201	35	jun	jun	PROPN
bptjm-33	201	36	n	n	CCONJ
bptjm-33	201	37	-	-	PUNCT
bptjm-33	201	38	terminal	terminal	ADJ
bptjm-33	201	39	kinase	kinase	NOUN
bptjm-33	201	40	,	,	PUNCT
bptjm-33	201	41	therefore	therefore	ADV
bptjm-33	201	42	increased	increase	VERB
bptjm-33	201	43	the	the	DET
bptjm-33	201	44	accumulation	accumulation	NOUN
bptjm-33	201	45	of	of	ADP
bptjm-33	201	46	aβ34	aβ34	PROPN
bptjm-33	201	47	,	,	PUNCT
bptjm-33	201	48	36	36	NUM
bptjm-33	201	49	.	.	PUNCT
bptjm-33	202	1	the	the	DET
bptjm-33	202	2	treatment	treatment	NOUN
bptjm-33	202	3	is	be	AUX
bptjm-33	202	4	relatively	relatively	ADV
bptjm-33	202	5	simple	simple	ADJ
bptjm-33	202	6	and	and	CCONJ
bptjm-33	202	7	noninvasive	noninvasive	ADJ
bptjm-33	202	8	,	,	PUNCT
bptjm-33	202	9	making	make	VERB
bptjm-33	202	10	it	it	PRON
bptjm-33	202	11	feasible	feasible	ADJ
bptjm-33	202	12	for	for	ADP
bptjm-33	202	13	common	common	ADJ
bptjm-33	202	14	use	use	NOUN
bptjm-33	202	15	in	in	ADP
bptjm-33	202	16	clinical	clinical	ADJ
bptjm-33	202	17	settings35	settings35	NOUN
bptjm-33	202	18	.	.	PUNCT
bptjm-33	203	1	lastly	lastly	ADV
bptjm-33	203	2	,	,	PUNCT
bptjm-33	203	3	it	it	PRON
bptjm-33	203	4	has	have	AUX
bptjm-33	203	5	proven	prove	VERB
bptjm-33	203	6	to	to	PART
bptjm-33	203	7	be	be	AUX
bptjm-33	203	8	more	more	ADJ
bptjm-33	203	9	cost	cost	NOUN
bptjm-33	203	10	-	-	PUNCT
bptjm-33	203	11	effective	effective	ADJ
bptjm-33	203	12	than	than	ADP
bptjm-33	203	13	the	the	DET
bptjm-33	203	14	current	current	ADJ
bptjm-33	203	15	or	or	CCONJ
bptjm-33	203	16	competing	compete	VERB
bptjm-33	203	17	biomarkers	biomarker	NOUN
bptjm-33	203	18	for	for	ADP
bptjm-33	203	19	ad34	ad34	PROPN
bptjm-33	203	20	.	.	PROPN
bptjm-33	204	1	7.2	7.2	NUM
bptjm-33	204	2	.	.	PUNCT
bptjm-33	205	1	mirna	mirna	PROPN
bptjm-33	205	2	uncertainty	uncertainty	NOUN
bptjm-33	205	3	a	a	DET
bptjm-33	205	4	drawback	drawback	NOUN
bptjm-33	205	5	or	or	CCONJ
bptjm-33	205	6	point	point	NOUN
bptjm-33	205	7	of	of	ADP
bptjm-33	205	8	uncertainty	uncertainty	NOUN
bptjm-33	205	9	in	in	ADP
bptjm-33	205	10	the	the	DET
bptjm-33	205	11	research	research	NOUN
bptjm-33	205	12	of	of	ADP
bptjm-33	205	13	mirna	mirna	PROPN
bptjm-33	205	14	as	as	ADP
bptjm-33	205	15	therapeutics	therapeutic	NOUN
bptjm-33	205	16	for	for	ADP
bptjm-33	205	17	alzheimer	alzheimer	PROPN
bptjm-33	205	18	’s	’s	PART
bptjm-33	205	19	is	be	AUX
bptjm-33	205	20	the	the	DET
bptjm-33	205	21	discrepancy	discrepancy	NOUN
bptjm-33	205	22	between	between	ADP
bptjm-33	205	23	the	the	DET
bptjm-33	205	24	different	different	ADJ
bptjm-33	205	25	trials	trial	NOUN
bptjm-33	205	26	and	and	CCONJ
bptjm-33	205	27	projects	project	NOUN
bptjm-33	205	28	,	,	PUNCT
bptjm-33	205	29	starting	start	VERB
bptjm-33	205	30	from	from	ADP
bptjm-33	205	31	the	the	DET
bptjm-33	205	32	beginning	beginning	NOUN
bptjm-33	205	33	at	at	ADP
bptjm-33	205	34	the	the	DET
bptjm-33	205	35	root	root	NOUN
bptjm-33	205	36	of	of	ADP
bptjm-33	205	37	the	the	DET
bptjm-33	205	38	collection34	collection34	NOUN
bptjm-33	205	39	.	.	PUNCT
bptjm-33	206	1	sometimes	sometimes	ADV
bptjm-33	206	2	the	the	DET
bptjm-33	206	3	mirnas	mirna	NOUN
bptjm-33	206	4	are	be	AUX
bptjm-33	206	5	extracted	extract	VERB
bptjm-33	206	6	from	from	ADP
bptjm-33	206	7	the	the	DET
bptjm-33	206	8	plasma	plasma	NOUN
bptjm-33	206	9	in	in	ADP
bptjm-33	206	10	the	the	DET
bptjm-33	206	11	patient	patient	NOUN
bptjm-33	206	12	’s	’s	PART
bptjm-33	206	13	blood	blood	NOUN
bptjm-33	206	14	,	,	PUNCT
bptjm-33	206	15	and	and	CCONJ
bptjm-33	206	16	other	other	ADJ
bptjm-33	206	17	times	time	NOUN
bptjm-33	206	18	in	in	ADP
bptjm-33	206	19	the	the	DET
bptjm-33	206	20	csf	csf	NOUN
bptjm-33	206	21	.	.	PUNCT
bptjm-33	207	1	the	the	DET
bptjm-33	207	2	best	good	ADJ
bptjm-33	207	3	example	example	NOUN
bptjm-33	207	4	is	be	AUX
bptjm-33	207	5	mir-342	mir-342	NOUN
bptjm-33	207	6	-	-	PUNCT
bptjm-33	207	7	3p	3p	NUM
bptjm-33	207	8	,	,	PUNCT
bptjm-33	207	9	a	a	DET
bptjm-33	207	10	better	well	ADJ
bptjm-33	207	11	biomarker	biomarker	NOUN
bptjm-33	207	12	in	in	ADP
bptjm-33	207	13	blood	blood	NOUN
bptjm-33	207	14	,	,	PUNCT
bptjm-33	207	15	and	and	CCONJ
bptjm-33	207	16	mir-127	mir-127	NOUN
bptjm-33	207	17	-	-	PUNCT
bptjm-33	207	18	3p	3p	NUM
bptjm-33	207	19	,	,	PUNCT
bptjm-33	207	20	a	a	DET
bptjm-33	207	21	better	well	ADJ
bptjm-33	207	22	biomarker	biomarker	NOUN
bptjm-33	207	23	in	in	ADP
bptjm-33	207	24	csf34	csf34	NOUN
bptjm-33	207	25	.	.	PUNCT
bptjm-33	208	1	this	this	DET
bptjm-33	208	2	discrepancy	discrepancy	NOUN
bptjm-33	208	3	,	,	PUNCT
bptjm-33	208	4	along	along	ADP
bptjm-33	208	5	with	with	ADP
bptjm-33	208	6	different	different	ADJ
bptjm-33	208	7	measurements	measurement	NOUN
bptjm-33	208	8	and	and	CCONJ
bptjm-33	208	9	amplifications	amplification	NOUN
bptjm-33	208	10	or	or	CCONJ
bptjm-33	208	11	testing	testing	NOUN
bptjm-33	208	12	methods	method	NOUN
bptjm-33	208	13	,	,	PUNCT
bptjm-33	208	14	has	have	AUX
bptjm-33	208	15	caused	cause	VERB
bptjm-33	208	16	different	different	ADJ
bptjm-33	208	17	results	result	NOUN
bptjm-33	208	18	from	from	ADP
bptjm-33	208	19	various	various	ADJ
bptjm-33	208	20	studies	study	NOUN
bptjm-33	208	21	.	.	PUNCT
bptjm-33	209	1	however	however	ADV
bptjm-33	209	2	,	,	PUNCT
bptjm-33	209	3	it	it	PRON
bptjm-33	209	4	is	be	AUX
bptjm-33	209	5	unlikely	unlikely	ADJ
bptjm-33	209	6	that	that	SCONJ
bptjm-33	209	7	only	only	ADV
bptjm-33	209	8	one	one	NUM
bptjm-33	209	9	specific	specific	ADJ
bptjm-33	209	10	approach	approach	NOUN
bptjm-33	209	11	would	would	AUX
bptjm-33	209	12	be	be	AUX
bptjm-33	209	13	used	use	VERB
bptjm-33	209	14	.	.	PUNCT
bptjm-33	210	1	it	it	PRON
bptjm-33	210	2	is	be	AUX
bptjm-33	210	3	instead	instead	ADV
bptjm-33	210	4	important	important	ADJ
bptjm-33	210	5	to	to	PART
bptjm-33	210	6	standardize	standardize	VERB
bptjm-33	210	7	each	each	DET
bptjm-33	210	8	type	type	NOUN
bptjm-33	210	9	of	of	ADP
bptjm-33	210	10	treatment	treatment	NOUN
bptjm-33	210	11	or	or	CCONJ
bptjm-33	210	12	biomarker	biomarker	NOUN
bptjm-33	210	13	.	.	PUNCT
bptjm-33	211	1	some	some	DET
bptjm-33	211	2	approaches	approach	NOUN
bptjm-33	211	3	are	be	AUX
bptjm-33	211	4	not	not	PART
bptjm-33	211	5	limited	limit	VERB
bptjm-33	211	6	to	to	ADP
bptjm-33	211	7	difficulties	difficulty	NOUN
bptjm-33	211	8	in	in	ADP
bptjm-33	211	9	delivering	deliver	VERB
bptjm-33	211	10	and	and	CCONJ
bptjm-33	211	11	targeting	target	VERB
bptjm-33	211	12	these	these	DET
bptjm-33	211	13	mirna	mirna	PROPN
bptjm-33	211	14	treatments	treatment	NOUN
bptjm-33	211	15	,	,	PUNCT
bptjm-33	211	16	safety	safety	NOUN
bptjm-33	211	17	issues	issue	NOUN
bptjm-33	211	18	,	,	PUNCT
bptjm-33	211	19	and	and	CCONJ
bptjm-33	211	20	off	off	ADP
bptjm-33	211	21	-	-	PUNCT
bptjm-33	211	22	target	target	NOUN
bptjm-33	211	23	effects	effect	NOUN
bptjm-33	211	24	of	of	ADP
bptjm-33	211	25	these	these	DET
bptjm-33	211	26	treatments37	treatments37	NOUN
bptjm-33	211	27	.	.	PUNCT
bptjm-33	212	1	these	these	DET
bptjm-33	212	2	mirnas	mirna	NOUN
bptjm-33	212	3	play	play	VERB
bptjm-33	212	4	a	a	DET
bptjm-33	212	5	role	role	NOUN
bptjm-33	212	6	in	in	ADP
bptjm-33	212	7	aβ	aβ	NOUN
bptjm-33	212	8	production	production	NOUN
bptjm-33	212	9	through	through	ADP
bptjm-33	212	10	cascades	cascade	NOUN
bptjm-33	212	11	of	of	ADP
bptjm-33	212	12	different	different	ADJ
bptjm-33	212	13	molecules	molecule	NOUN
bptjm-33	212	14	.	.	PUNCT
bptjm-33	213	1	similarly	similarly	ADV
bptjm-33	213	2	,	,	PUNCT
bptjm-33	213	3	they	they	PRON
bptjm-33	213	4	have	have	VERB
bptjm-33	213	5	control	control	NOUN
bptjm-33	213	6	over	over	ADP
bptjm-33	213	7	other	other	ADJ
bptjm-33	213	8	molecules	molecule	NOUN
bptjm-33	213	9	and	and	CCONJ
bptjm-33	213	10	proteins	protein	NOUN
bptjm-33	213	11	.	.	PUNCT
bptjm-33	214	1	so	so	ADV
bptjm-33	214	2	,	,	PUNCT
bptjm-33	214	3	by	by	ADP
bptjm-33	214	4	changing	change	VERB
bptjm-33	214	5	the	the	DET
bptjm-33	214	6	levels	level	NOUN
bptjm-33	214	7	of	of	ADP
bptjm-33	214	8	specific	specific	ADJ
bptjm-33	214	9	mirnas	mirna	NOUN
bptjm-33	214	10	apart	apart	ADV
bptjm-33	214	11	from	from	ADP
bptjm-33	214	12	the	the	DET
bptjm-33	214	13	aβ	aβ	NOUN
bptjm-33	214	14	pathway	pathway	NOUN
bptjm-33	214	15	being	be	AUX
bptjm-33	214	16	changed	change	VERB
bptjm-33	214	17	,	,	PUNCT
bptjm-33	214	18	other	other	ADJ
bptjm-33	214	19	molecules	molecule	NOUN
bptjm-33	214	20	and	and	CCONJ
bptjm-33	214	21	pathways	pathway	NOUN
bptjm-33	214	22	could	could	AUX
bptjm-33	214	23	have	have	VERB
bptjm-33	214	24	residual	residual	ADJ
bptjm-33	214	25	effects	effect	NOUN
bptjm-33	214	26	.	.	PUNCT
bptjm-33	215	1	berkeley	berkeley	PROPN
bptjm-33	215	2	pharma	pharma	PROPN
bptjm-33	215	3	tech	tech	PROPN
bptjm-33	215	4	journal	journal	NOUN
bptjm-33	215	5	of	of	ADP
bptjm-33	215	6	medicine	medicine	NOUN
bptjm-33	215	7	|	|	ADV
bptjm-33	215	8	64	64	NUM
bptjm-33	215	9	7.3	7.3	NUM
bptjm-33	215	10	.	.	PUNCT
bptjm-33	216	1	current	current	ADJ
bptjm-33	216	2	use	use	VERB
bptjm-33	216	3	the	the	DET
bptjm-33	216	4	idea	idea	NOUN
bptjm-33	216	5	of	of	ADP
bptjm-33	216	6	using	use	VERB
bptjm-33	216	7	mirna	mirna	PROPN
bptjm-33	216	8	has	have	AUX
bptjm-33	216	9	already	already	ADV
bptjm-33	216	10	been	be	AUX
bptjm-33	216	11	adapted	adapt	VERB
bptjm-33	216	12	into	into	ADP
bptjm-33	216	13	some	some	DET
bptjm-33	216	14	clinical	clinical	ADJ
bptjm-33	216	15	aspects	aspect	NOUN
bptjm-33	216	16	.	.	PUNCT
bptjm-33	217	1	there	there	PRON
bptjm-33	217	2	are	be	VERB
bptjm-33	217	3	patents	patent	NOUN
bptjm-33	217	4	in	in	ADP
bptjm-33	217	5	place	place	NOUN
bptjm-33	217	6	using	use	VERB
bptjm-33	217	7	the	the	DET
bptjm-33	217	8	technique	technique	NOUN
bptjm-33	217	9	of	of	ADP
bptjm-33	217	10	mirna	mirna	NOUN
bptjm-33	217	11	as	as	ADP
bptjm-33	217	12	biomarkers	biomarker	NOUN
bptjm-33	217	13	and	and	CCONJ
bptjm-33	217	14	therapies	therapy	NOUN
bptjm-33	217	15	.	.	PUNCT
bptjm-33	218	1	one	one	NUM
bptjm-33	218	2	patent	patent	NOUN
bptjm-33	218	3	that	that	PRON
bptjm-33	218	4	has	have	AUX
bptjm-33	218	5	been	be	AUX
bptjm-33	218	6	filed	file	VERB
bptjm-33	218	7	and	and	CCONJ
bptjm-33	218	8	granted	grant	VERB
bptjm-33	218	9	claims	claim	NOUN
bptjm-33	218	10	to	to	PART
bptjm-33	218	11	be	be	AUX
bptjm-33	218	12	an	an	DET
bptjm-33	218	13	invention	invention	NOUN
bptjm-33	218	14	that	that	PRON
bptjm-33	218	15	is	be	AUX
bptjm-33	218	16	able	able	ADJ
bptjm-33	218	17	to	to	PART
bptjm-33	218	18	measure	measure	VERB
bptjm-33	218	19	the	the	DET
bptjm-33	218	20	level	level	NOUN
bptjm-33	218	21	of	of	ADP
bptjm-33	218	22	one	one	NUM
bptjm-33	218	23	neurite	neurite	NOUN
bptjm-33	218	24	mirnas	mirna	NOUN
bptjm-33	218	25	,	,	PUNCT
bptjm-33	218	26	specific	specific	ADJ
bptjm-33	218	27	mirnas	mirna	NOUN
bptjm-33	218	28	that	that	PRON
bptjm-33	218	29	relate	relate	VERB
bptjm-33	218	30	to	to	ADP
bptjm-33	218	31	mci	mci	VERB
bptjm-33	218	32	,	,	PUNCT
bptjm-33	218	33	the	the	DET
bptjm-33	218	34	starting	starting	NOUN
bptjm-33	218	35	stage	stage	NOUN
bptjm-33	218	36	of	of	ADP
bptjm-33	218	37	ad	ad	NOUN
bptjm-33	218	38	.	.	PUNCT
bptjm-33	219	1	these	these	DET
bptjm-33	219	2	specific	specific	ADJ
bptjm-33	219	3	mirnas	mirna	NOUN
bptjm-33	219	4	include	include	VERB
bptjm-33	219	5	mir-7	mir-7	ADV
bptjm-33	219	6	,	,	PUNCT
bptjm-33	219	7	mir-125b	mir-125b	NOUN
bptjm-33	219	8	,	,	PUNCT
bptjm-33	219	9	mir-128	mir-128	NOUN
bptjm-33	219	10	,	,	PUNCT
bptjm-33	219	11	mir-132	mir-132	PROPN
bptjm-33	219	12	,	,	PUNCT
bptjm-33	219	13	mir-874	mir-874	INTJ
bptjm-33	219	14	,	,	PUNCT
bptjm-33	219	15	mir134	mir134	PROPN
bptjm-33	219	16	,	,	PUNCT
bptjm-33	219	17	mir-323	mir-323	ADJ
bptjm-33	219	18	-	-	PUNCT
bptjm-33	219	19	3p	3p	NUM
bptjm-33	219	20	,	,	PUNCT
bptjm-33	219	21	and	and	CCONJ
bptjm-33	219	22	mir-38238	mir-38238	NOUN
bptjm-33	219	23	.	.	PUNCT
bptjm-33	220	1	another	another	DET
bptjm-33	220	2	patent	patent	NOUN
bptjm-33	220	3	in	in	ADP
bptjm-33	220	4	china	china	PROPN
bptjm-33	220	5	has	have	AUX
bptjm-33	220	6	published	publish	VERB
bptjm-33	220	7	a	a	DET
bptjm-33	220	8	similar	similar	ADJ
bptjm-33	220	9	invention	invention	NOUN
bptjm-33	220	10	in	in	ADP
bptjm-33	220	11	which	which	PRON
bptjm-33	220	12	mirna	mirna	NOUN
bptjm-33	220	13	is	be	AUX
bptjm-33	220	14	used	use	VERB
bptjm-33	220	15	as	as	ADP
bptjm-33	220	16	a	a	DET
bptjm-33	220	17	biomarker	biomarker	NOUN
bptjm-33	220	18	to	to	PART
bptjm-33	220	19	diagnose	diagnose	VERB
bptjm-33	220	20	alzheimer	alzheimer	PROPN
bptjm-33	220	21	's	's	PART
bptjm-33	220	22	in	in	ADP
bptjm-33	220	23	patients	patient	NOUN
bptjm-33	220	24	.	.	PUNCT
bptjm-33	221	1	this	this	DET
bptjm-33	221	2	invention	invention	NOUN
bptjm-33	221	3	is	be	AUX
bptjm-33	221	4	said	say	VERB
bptjm-33	221	5	to	to	PART
bptjm-33	221	6	compare	compare	VERB
bptjm-33	221	7	mirnas	mirna	NOUN
bptjm-33	221	8	such	such	ADJ
bptjm-33	221	9	as	as	ADP
bptjm-33	221	10	mir-191	mir-191	NOUN
bptjm-33	221	11	,	,	PUNCT
bptjm-33	221	12	mir-15b	mir-15b	NOUN
bptjm-33	221	13	,	,	PUNCT
bptjm-33	221	14	and	and	CCONJ
bptjm-33	221	15	mir-142	mir-142	NOUN
bptjm-33	221	16	-	-	PUNCT
bptjm-33	221	17	3p	3p	NUM
bptjm-33	221	18	with	with	ADP
bptjm-33	221	19	healthy	healthy	ADJ
bptjm-33	221	20	controls	control	NOUN
bptjm-33	221	21	to	to	PART
bptjm-33	221	22	determine	determine	VERB
bptjm-33	221	23	if	if	SCONJ
bptjm-33	221	24	the	the	DET
bptjm-33	221	25	given	give	VERB
bptjm-33	221	26	sample	sample	NOUN
bptjm-33	221	27	has	have	VERB
bptjm-33	221	28	the	the	DET
bptjm-33	221	29	precursors	precursor	NOUN
bptjm-33	221	30	for	for	ADP
bptjm-33	221	31	ad39	ad39	PROPN
bptjm-33	221	32	.	.	PROPN
bptjm-33	222	1	8	8	NUM
bptjm-33	222	2	.	.	PUNCT
bptjm-33	223	1	future	future	ADJ
bptjm-33	223	2	directions	direction	NOUN
bptjm-33	223	3	8.1	8.1	NUM
bptjm-33	223	4	.	.	PUNCT
bptjm-33	224	1	mirna	mirna	PROPN
bptjm-33	224	2	delivery	delivery	NOUN
bptjm-33	224	3	one	one	NUM
bptjm-33	224	4	step	step	NOUN
bptjm-33	224	5	for	for	ADP
bptjm-33	224	6	the	the	DET
bptjm-33	224	7	future	future	NOUN
bptjm-33	224	8	of	of	ADP
bptjm-33	224	9	this	this	DET
bptjm-33	224	10	novel	novel	ADJ
bptjm-33	224	11	treatment	treatment	NOUN
bptjm-33	224	12	is	be	AUX
bptjm-33	224	13	enhancing	enhance	VERB
bptjm-33	224	14	the	the	DET
bptjm-33	224	15	delivery	delivery	NOUN
bptjm-33	224	16	method	method	NOUN
bptjm-33	224	17	of	of	ADP
bptjm-33	224	18	the	the	DET
bptjm-33	224	19	mirna	mirna	PROPN
bptjm-33	224	20	therapies	therapy	NOUN
bptjm-33	224	21	.	.	PUNCT
bptjm-33	225	1	mirna	mirna	PROPN
bptjm-33	225	2	therapy	therapy	NOUN
bptjm-33	225	3	is	be	AUX
bptjm-33	225	4	very	very	ADV
bptjm-33	225	5	targeted	target	VERB
bptjm-33	225	6	;	;	PUNCT
bptjm-33	225	7	therefore	therefore	ADV
bptjm-33	225	8	,	,	PUNCT
bptjm-33	225	9	alzheimer	alzheimer	PROPN
bptjm-33	225	10	's	's	PART
bptjm-33	225	11	patients	patient	NOUN
bptjm-33	225	12	would	would	AUX
bptjm-33	225	13	need	need	VERB
bptjm-33	225	14	the	the	DET
bptjm-33	225	15	mirna	mirna	NOUN
bptjm-33	225	16	injected	inject	VERB
bptjm-33	225	17	directly	directly	ADV
bptjm-33	225	18	into	into	ADP
bptjm-33	225	19	the	the	DET
bptjm-33	225	20	cns40,41	cns40,41	PROPN
bptjm-33	225	21	.	.	PROPN
bptjm-33	226	1	mirna	mirna	PROPN
bptjm-33	226	2	can	can	AUX
bptjm-33	226	3	not	not	PART
bptjm-33	226	4	pass	pass	VERB
bptjm-33	226	5	through	through	ADP
bptjm-33	226	6	the	the	DET
bptjm-33	226	7	blood	blood	NOUN
bptjm-33	226	8	-	-	PUNCT
bptjm-33	226	9	brain	brain	NOUN
bptjm-33	226	10	barrier	barrier	NOUN
bptjm-33	226	11	,	,	PUNCT
bptjm-33	226	12	so	so	SCONJ
bptjm-33	226	13	conventional	conventional	ADJ
bptjm-33	226	14	techniques	technique	NOUN
bptjm-33	226	15	would	would	AUX
bptjm-33	226	16	not	not	PART
bptjm-33	226	17	be	be	AUX
bptjm-33	226	18	adequate40	adequate40	ADV
bptjm-33	226	19	.	.	PUNCT
bptjm-33	227	1	the	the	DET
bptjm-33	227	2	system	system	NOUN
bptjm-33	227	3	by	by	ADP
bptjm-33	227	4	which	which	PRON
bptjm-33	227	5	the	the	DET
bptjm-33	227	6	treatment	treatment	NOUN
bptjm-33	227	7	is	be	AUX
bptjm-33	227	8	delivered	deliver	VERB
bptjm-33	227	9	is	be	AUX
bptjm-33	227	10	important	important	ADJ
bptjm-33	227	11	as	as	SCONJ
bptjm-33	227	12	it	it	PRON
bptjm-33	227	13	affects	affect	VERB
bptjm-33	227	14	how	how	SCONJ
bptjm-33	227	15	feasible	feasible	ADJ
bptjm-33	227	16	and	and	CCONJ
bptjm-33	227	17	applicable	applicable	ADJ
bptjm-33	227	18	it	it	PRON
bptjm-33	227	19	is	be	AUX
bptjm-33	227	20	in	in	ADP
bptjm-33	227	21	the	the	DET
bptjm-33	227	22	clinical	clinical	ADJ
bptjm-33	227	23	world	world	NOUN
bptjm-33	227	24	as	as	ADV
bptjm-33	227	25	well	well	ADV
bptjm-33	227	26	as	as	ADP
bptjm-33	227	27	its	its	PRON
bptjm-33	227	28	effectiveness	effectiveness	NOUN
bptjm-33	227	29	.	.	PUNCT
bptjm-33	228	1	8.2	8.2	NUM
bptjm-33	228	2	.	.	PUNCT
bptjm-33	229	1	mirna	mirna	PROPN
bptjm-33	229	2	studies	study	NOUN
bptjm-33	229	3	currently	currently	ADV
bptjm-33	229	4	,	,	PUNCT
bptjm-33	229	5	there	there	PRON
bptjm-33	229	6	is	be	VERB
bptjm-33	229	7	promise	promise	NOUN
bptjm-33	229	8	in	in	ADP
bptjm-33	229	9	mirna	mirna	PROPN
bptjm-33	229	10	studies	study	NOUN
bptjm-33	229	11	;	;	PUNCT
bptjm-33	229	12	however	however	ADV
bptjm-33	229	13	,	,	PUNCT
bptjm-33	229	14	there	there	PRON
bptjm-33	229	15	are	be	VERB
bptjm-33	229	16	limited	limit	VERB
bptjm-33	229	17	clinical	clinical	ADJ
bptjm-33	229	18	trials	trial	NOUN
bptjm-33	229	19	that	that	PRON
bptjm-33	229	20	are	be	AUX
bptjm-33	229	21	ongoing	ongoing	ADJ
bptjm-33	229	22	that	that	SCONJ
bptjm-33	229	23	study	study	NOUN
bptjm-33	229	24	this	this	DET
bptjm-33	229	25	potential	potential	ADJ
bptjm-33	229	26	therapy41	therapy41	NOUN
bptjm-33	229	27	.	.	PUNCT
bptjm-33	230	1	having	have	VERB
bptjm-33	230	2	more	more	ADJ
bptjm-33	230	3	of	of	ADP
bptjm-33	230	4	these	these	DET
bptjm-33	230	5	studies	study	NOUN
bptjm-33	230	6	in	in	ADP
bptjm-33	230	7	the	the	DET
bptjm-33	230	8	future	future	NOUN
bptjm-33	230	9	will	will	AUX
bptjm-33	230	10	help	help	VERB
bptjm-33	230	11	the	the	DET
bptjm-33	230	12	understanding	understanding	NOUN
bptjm-33	230	13	of	of	ADP
bptjm-33	230	14	this	this	DET
bptjm-33	230	15	therapy	therapy	NOUN
bptjm-33	230	16	and	and	CCONJ
bptjm-33	230	17	has	have	VERB
bptjm-33	230	18	the	the	DET
bptjm-33	230	19	potential	potential	NOUN
bptjm-33	230	20	to	to	PART
bptjm-33	230	21	make	make	VERB
bptjm-33	230	22	it	it	PRON
bptjm-33	230	23	a	a	DET
bptjm-33	230	24	more	more	ADV
bptjm-33	230	25	conventional	conventional	ADJ
bptjm-33	230	26	practice	practice	NOUN
bptjm-33	230	27	in	in	ADP
bptjm-33	230	28	the	the	DET
bptjm-33	230	29	medical	medical	ADJ
bptjm-33	230	30	field	field	NOUN
bptjm-33	230	31	for	for	ADP
bptjm-33	230	32	diagnosing	diagnose	VERB
bptjm-33	230	33	and	and	CCONJ
bptjm-33	230	34	treating	treat	VERB
bptjm-33	230	35	ad	ad	NOUN
bptjm-33	230	36	.	.	PUNCT
bptjm-33	231	1	there	there	PRON
bptjm-33	231	2	are	be	VERB
bptjm-33	231	3	also	also	ADV
bptjm-33	231	4	other	other	ADJ
bptjm-33	231	5	issues	issue	NOUN
bptjm-33	231	6	that	that	PRON
bptjm-33	231	7	need	need	VERB
bptjm-33	231	8	to	to	PART
bptjm-33	231	9	be	be	AUX
bptjm-33	231	10	addressed	address	VERB
bptjm-33	231	11	,	,	PUNCT
bptjm-33	231	12	such	such	ADJ
bptjm-33	231	13	as	as	ADP
bptjm-33	231	14	the	the	DET
bptjm-33	231	15	tolerance	tolerance	NOUN
bptjm-33	231	16	of	of	ADP
bptjm-33	231	17	the	the	DET
bptjm-33	231	18	patient	patient	NOUN
bptjm-33	231	19	’s	’s	PART
bptjm-33	231	20	mirna	mirna	PROPN
bptjm-33	231	21	supplementation	supplementation	NOUN
bptjm-33	231	22	or	or	CCONJ
bptjm-33	231	23	inhibition41	inhibition41	NOUN
bptjm-33	231	24	.	.	PUNCT
bptjm-33	232	1	the	the	DET
bptjm-33	232	2	lag	lag	NOUN
bptjm-33	232	3	of	of	ADP
bptjm-33	232	4	mirna	mirna	PROPN
bptjm-33	232	5	therapies	therapy	NOUN
bptjm-33	232	6	,	,	PUNCT
bptjm-33	232	7	compared	compare	VERB
bptjm-33	232	8	to	to	ADP
bptjm-33	232	9	treatments	treatment	NOUN
bptjm-33	232	10	of	of	ADP
bptjm-33	232	11	other	other	ADJ
bptjm-33	232	12	common	common	ADJ
bptjm-33	232	13	or	or	CCONJ
bptjm-33	232	14	deadly	deadly	ADJ
bptjm-33	232	15	illnesses	illness	NOUN
bptjm-33	232	16	,	,	PUNCT
bptjm-33	232	17	decreases	decrease	VERB
bptjm-33	232	18	the	the	DET
bptjm-33	232	19	potential	potential	NOUN
bptjm-33	232	20	of	of	ADP
bptjm-33	232	21	issues	issue	NOUN
bptjm-33	232	22	like	like	ADP
bptjm-33	232	23	this	this	PRON
bptjm-33	232	24	from	from	ADP
bptjm-33	232	25	being	be	AUX
bptjm-33	232	26	resolved	resolve	VERB
bptjm-33	232	27	.	.	PUNCT
bptjm-33	233	1	more	more	ADJ
bptjm-33	233	2	research	research	NOUN
bptjm-33	233	3	needs	need	VERB
bptjm-33	233	4	to	to	PART
bptjm-33	233	5	be	be	AUX
bptjm-33	233	6	done	do	VERB
bptjm-33	233	7	to	to	PART
bptjm-33	233	8	garner	garner	VERB
bptjm-33	233	9	a	a	DET
bptjm-33	233	10	holistic	holistic	ADJ
bptjm-33	233	11	view	view	NOUN
bptjm-33	233	12	of	of	ADP
bptjm-33	233	13	mirna	mirna	PROPN
bptjm-33	233	14	therapy	therapy	NOUN
bptjm-33	233	15	.	.	PUNCT
bptjm-33	234	1	berkeley	berkeley	PROPN
bptjm-33	234	2	pharma	pharma	PROPN
bptjm-33	234	3	tech	tech	PROPN
bptjm-33	234	4	journal	journal	NOUN
bptjm-33	234	5	of	of	ADP
bptjm-33	234	6	medicine	medicine	NOUN
bptjm-33	234	7	|	|	ADV
bptjm-33	234	8	65	65	NUM
bptjm-33	234	9	9	9	NUM
bptjm-33	234	10	.	.	PUNCT
bptjm-33	235	1	conclusion	conclusion	PROPN
bptjm-33	235	2	alzheimer	alzheimer	PROPN
bptjm-33	235	3	’s	’s	PART
bptjm-33	235	4	disease	disease	NOUN
bptjm-33	235	5	(	(	PUNCT
bptjm-33	235	6	ad	ad	NOUN
bptjm-33	235	7	)	)	PUNCT
bptjm-33	235	8	is	be	AUX
bptjm-33	235	9	a	a	DET
bptjm-33	235	10	progressive	progressive	ADJ
bptjm-33	235	11	neurodegenerative	neurodegenerative	ADJ
bptjm-33	235	12	disease	disease	NOUN
bptjm-33	235	13	and	and	CCONJ
bptjm-33	235	14	is	be	AUX
bptjm-33	235	15	the	the	DET
bptjm-33	235	16	leading	lead	VERB
bptjm-33	235	17	cause	cause	NOUN
bptjm-33	235	18	of	of	ADP
bptjm-33	235	19	dementia	dementia	NOUN
bptjm-33	235	20	across	across	ADP
bptjm-33	235	21	the	the	DET
bptjm-33	235	22	globe	globe	NOUN
bptjm-33	235	23	.	.	PUNCT
bptjm-33	236	1	ad	ad	NOUN
bptjm-33	236	2	is	be	AUX
bptjm-33	236	3	frequently	frequently	ADV
bptjm-33	236	4	characterized	characterize	VERB
bptjm-33	236	5	by	by	ADP
bptjm-33	236	6	the	the	DET
bptjm-33	236	7	deposition	deposition	NOUN
bptjm-33	236	8	of	of	ADP
bptjm-33	236	9	aβ	aβ	DET
bptjm-33	236	10	plaques	plaque	NOUN
bptjm-33	236	11	and	and	CCONJ
bptjm-33	236	12	the	the	DET
bptjm-33	236	13	formation	formation	NOUN
bptjm-33	236	14	of	of	ADP
bptjm-33	236	15	nfts	nft	NOUN
bptjm-33	236	16	in	in	ADP
bptjm-33	236	17	the	the	DET
bptjm-33	236	18	brain	brain	NOUN
bptjm-33	236	19	.	.	PUNCT
bptjm-33	237	1	despite	despite	SCONJ
bptjm-33	237	2	continued	continued	ADJ
bptjm-33	237	3	research	research	NOUN
bptjm-33	237	4	into	into	ADP
bptjm-33	237	5	the	the	DET
bptjm-33	237	6	disease	disease	NOUN
bptjm-33	237	7	,	,	PUNCT
bptjm-33	237	8	ad	ad	NOUN
bptjm-33	237	9	continues	continue	VERB
bptjm-33	237	10	to	to	PART
bptjm-33	237	11	be	be	AUX
bptjm-33	237	12	one	one	NUM
bptjm-33	237	13	of	of	ADP
bptjm-33	237	14	the	the	DET
bptjm-33	237	15	leading	lead	VERB
bptjm-33	237	16	causes	cause	NOUN
bptjm-33	237	17	of	of	ADP
bptjm-33	237	18	mortality	mortality	NOUN
bptjm-33	237	19	in	in	ADP
bptjm-33	237	20	elderly	elderly	ADJ
bptjm-33	237	21	populations	population	NOUN
bptjm-33	237	22	globally	globally	ADV
bptjm-33	237	23	,	,	PUNCT
bptjm-33	237	24	thus	thus	ADV
bptjm-33	237	25	highlighting	highlight	VERB
bptjm-33	237	26	the	the	DET
bptjm-33	237	27	need	need	NOUN
bptjm-33	237	28	for	for	ADP
bptjm-33	237	29	novel	novel	ADJ
bptjm-33	237	30	and	and	CCONJ
bptjm-33	237	31	advanced	advanced	ADJ
bptjm-33	237	32	therapies	therapy	NOUN
bptjm-33	237	33	that	that	PRON
bptjm-33	237	34	can	can	AUX
bptjm-33	237	35	produce	produce	VERB
bptjm-33	237	36	robust	robust	ADJ
bptjm-33	237	37	anti	anti	ADJ
bptjm-33	237	38	-	-	ADJ
bptjm-33	237	39	ad	ad	ADJ
bptjm-33	237	40	effects	effect	NOUN
bptjm-33	237	41	.	.	PUNCT
bptjm-33	238	1	current	current	ADJ
bptjm-33	238	2	ad	ad	NOUN
bptjm-33	238	3	treatments	treatment	NOUN
bptjm-33	238	4	are	be	AUX
bptjm-33	238	5	typically	typically	ADV
bptjm-33	238	6	invasive	invasive	ADJ
bptjm-33	238	7	,	,	PUNCT
bptjm-33	238	8	costly	costly	ADJ
bptjm-33	238	9	,	,	PUNCT
bptjm-33	238	10	and	and	CCONJ
bptjm-33	238	11	noncurative	noncurative	ADJ
bptjm-33	238	12	,	,	PUNCT
bptjm-33	238	13	thus	thus	ADV
bptjm-33	238	14	highlighting	highlight	VERB
bptjm-33	238	15	micrornas	microrna	NOUN
bptjm-33	238	16	as	as	ADP
bptjm-33	238	17	an	an	DET
bptjm-33	238	18	attractive	attractive	ADJ
bptjm-33	238	19	alternative	alternative	NOUN
bptjm-33	238	20	for	for	ADP
bptjm-33	238	21	the	the	DET
bptjm-33	238	22	care	care	NOUN
bptjm-33	238	23	of	of	ADP
bptjm-33	238	24	ad	ad	NOUN
bptjm-33	238	25	patients	patient	NOUN
bptjm-33	238	26	.	.	PUNCT
bptjm-33	239	1	mirnas	mirna	NOUN
bptjm-33	239	2	are	be	AUX
bptjm-33	239	3	associated	associate	VERB
bptjm-33	239	4	with	with	ADP
bptjm-33	239	5	several	several	ADJ
bptjm-33	239	6	neurodegenerative	neurodegenerative	ADJ
bptjm-33	239	7	diseases	disease	NOUN
bptjm-33	239	8	and	and	CCONJ
bptjm-33	239	9	play	play	VERB
bptjm-33	239	10	an	an	DET
bptjm-33	239	11	outsized	outsized	ADJ
bptjm-33	239	12	role	role	NOUN
bptjm-33	239	13	in	in	ADP
bptjm-33	239	14	the	the	DET
bptjm-33	239	15	pathogenesis	pathogenesis	NOUN
bptjm-33	239	16	of	of	ADP
bptjm-33	239	17	ad	ad	NOUN
bptjm-33	239	18	.	.	PUNCT
bptjm-33	240	1	several	several	ADJ
bptjm-33	240	2	classes	class	NOUN
bptjm-33	240	3	and	and	CCONJ
bptjm-33	240	4	families	family	NOUN
bptjm-33	240	5	of	of	ADP
bptjm-33	240	6	mirnas	mirna	NOUN
bptjm-33	240	7	are	be	AUX
bptjm-33	240	8	shown	show	VERB
bptjm-33	240	9	to	to	PART
bptjm-33	240	10	be	be	AUX
bptjm-33	240	11	either	either	CCONJ
bptjm-33	240	12	upregulated	upregulate	VERB
bptjm-33	240	13	or	or	CCONJ
bptjm-33	240	14	underexpressed	underexpresse	VERB
bptjm-33	240	15	in	in	ADP
bptjm-33	240	16	amyloid	amyloid	NOUN
bptjm-33	240	17	-	-	PUNCT
bptjm-33	240	18	beta	beta	NOUN
bptjm-33	240	19	and	and	CCONJ
bptjm-33	240	20	ad	ad	NOUN
bptjm-33	240	21	models	model	NOUN
bptjm-33	240	22	and	and	CCONJ
bptjm-33	240	23	cell	cell	NOUN
bptjm-33	240	24	cultures	culture	NOUN
bptjm-33	240	25	,	,	PUNCT
bptjm-33	240	26	therefore	therefore	ADV
bptjm-33	240	27	making	make	VERB
bptjm-33	240	28	the	the	DET
bptjm-33	240	29	targeting	targeting	NOUN
bptjm-33	240	30	of	of	ADP
bptjm-33	240	31	the	the	DET
bptjm-33	240	32	relationship	relationship	NOUN
bptjm-33	240	33	between	between	ADP
bptjm-33	240	34	mirnas	mirna	NOUN
bptjm-33	240	35	and	and	CCONJ
bptjm-33	240	36	the	the	DET
bptjm-33	240	37	protein	protein	NOUN
bptjm-33	240	38	signaling	signal	VERB
bptjm-33	240	39	an	an	DET
bptjm-33	240	40	important	important	ADJ
bptjm-33	240	41	agent	agent	NOUN
bptjm-33	240	42	for	for	ADP
bptjm-33	240	43	the	the	DET
bptjm-33	240	44	diagnostic	diagnostic	ADJ
bptjm-33	240	45	and	and	CCONJ
bptjm-33	240	46	treatment	treatment	NOUN
bptjm-33	240	47	potential	potential	NOUN
bptjm-33	240	48	of	of	ADP
bptjm-33	240	49	the	the	DET
bptjm-33	240	50	disease	disease	NOUN
bptjm-33	240	51	.	.	PUNCT
bptjm-33	241	1	conflicts	conflict	NOUN
bptjm-33	241	2	of	of	ADP
bptjm-33	241	3	interest	interest	NOUN
bptjm-33	241	4	the	the	DET
bptjm-33	241	5	authors	author	NOUN
bptjm-33	241	6	declare	declare	VERB
bptjm-33	241	7	that	that	SCONJ
bptjm-33	241	8	there	there	PRON
bptjm-33	241	9	is	be	VERB
bptjm-33	241	10	no	no	DET
bptjm-33	241	11	conflict	conflict	NOUN
bptjm-33	241	12	of	of	ADP
bptjm-33	241	13	interest	interest	NOUN
bptjm-33	241	14	regarding	regard	VERB
bptjm-33	241	15	the	the	DET
bptjm-33	241	16	publication	publication	NOUN
bptjm-33	241	17	of	of	ADP
bptjm-33	241	18	this	this	DET
bptjm-33	241	19	paper	paper	NOUN
bptjm-33	241	20	.	.	PUNCT
bptjm-33	242	1	references	reference	NOUN
bptjm-33	242	2	1	1	NUM
bptjm-33	242	3	.	.	PUNCT
bptjm-33	243	1	rahman	rahman	PROPN
bptjm-33	243	2	mr	mr	PROPN
bptjm-33	243	3	,	,	PUNCT
bptjm-33	243	4	islam	islam	PROPN
bptjm-33	243	5	t	t	PROPN
bptjm-33	243	6	,	,	PUNCT
bptjm-33	243	7	zaman	zaman	PROPN
bptjm-33	243	8	t	t	PROPN
bptjm-33	243	9	,	,	PUNCT
bptjm-33	243	10	et	et	PROPN
bptjm-33	243	11	al	al	PROPN
bptjm-33	243	12	.	.	PUNCT
bptjm-33	243	13	identi	identi	PROPN
bptjm-33	243	14	�	�	PROPN
bptjm-33	243	15	cation	cation	NOUN
bptjm-33	243	16	of	of	ADP
bptjm-33	243	17	molecular	molecular	ADJ
bptjm-33	243	18	signatures	signature	NOUN
bptjm-33	243	19	and	and	CCONJ
bptjm-33	243	20	pathways	pathway	NOUN
bptjm-33	243	21	to	to	PART
bptjm-33	243	22	identify	identify	VERB
bptjm-33	243	23	novel	novel	ADJ
bptjm-33	243	24	therapeutic	therapeutic	ADJ
bptjm-33	243	25	targets	target	NOUN
bptjm-33	243	26	in	in	ADP
bptjm-33	243	27	alzheimer	alzheimer	PROPN
bptjm-33	243	28	's	's	PART
bptjm-33	243	29	disease	disease	NOUN
bptjm-33	243	30	:	:	PUNCT
bptjm-33	243	31	insights	insight	NOUN
bptjm-33	243	32	from	from	ADP
bptjm-33	243	33	a	a	DET
bptjm-33	243	34	systems	system	NOUN
bptjm-33	243	35	biomedicine	biomedicine	NOUN
bptjm-33	243	36	perspective	perspective	NOUN
bptjm-33	243	37	.	.	PUNCT
bptjm-33	244	1	genomics	genomic	NOUN
bptjm-33	244	2	.	.	PUNCT
bptjm-33	245	1	https://www.sciencedirect.com/science/article/	https://www.sciencedirect.com/science/article/	PROPN
bptjm-33	245	2	pii	pii	PROPN
bptjm-33	245	3	/	/	SYM
bptjm-33	245	4	s0888754319301843?via%3dihub	s0888754319301843?via%3dihub	PROPN
bptjm-33	245	5	.	.	PUNCT
bptjm-33	246	1	published	publish	VERB
bptjm-33	246	2	august	august	PROPN
bptjm-33	246	3	1	1	NUM
bptjm-33	246	4	,	,	PUNCT
bptjm-33	246	5	2019	2019	NUM
bptjm-33	246	6	.	.	PUNCT
bptjm-33	247	1	accessed	access	VERB
bptjm-33	247	2	october	october	PROPN
bptjm-33	247	3	3	3	NUM
bptjm-33	247	4	,	,	PUNCT
bptjm-33	247	5	2022	2022	NUM
bptjm-33	247	6	.	.	PUNCT
bptjm-33	248	1	2	2	NUM
bptjm-33	248	2	.	.	X
bptjm-33	248	3	wu	wu	PROPN
bptjm-33	248	4	hzy	hzy	PROPN
bptjm-33	248	5	,	,	PUNCT
bptjm-33	248	6	thalamuthu	thalamuthu	VERB
bptjm-33	248	7	a	a	PRON
bptjm-33	248	8	,	,	PUNCT
bptjm-33	248	9	cheng	cheng	PROPN
bptjm-33	248	10	l	l	PROPN
bptjm-33	248	11	,	,	PUNCT
bptjm-33	248	12	et	et	PROPN
bptjm-33	248	13	al	al	PROPN
bptjm-33	248	14	.	.	PROPN
bptjm-33	248	15	di	di	PROPN
bptjm-33	248	16	�	�	PROPN
bptjm-33	248	17	erential	erential	ADJ
bptjm-33	248	18	blood	blood	NOUN
bptjm-33	248	19	mirna	mirna	NOUN
bptjm-33	248	20	expression	expression	NOUN
bptjm-33	248	21	in	in	ADP
bptjm-33	248	22	brain	brain	NOUN
bptjm-33	248	23	amyloid	amyloid	NOUN
bptjm-33	248	24	imaging	imaging	NOUN
bptjm-33	248	25	-	-	PUNCT
bptjm-33	248	26	de	de	X
bptjm-33	248	27	�	�	PROPN
bptjm-33	248	28	ned	ned	ADJ
bptjm-33	248	29	alzheimer	alzheimer	PROPN
bptjm-33	248	30	's	's	PART
bptjm-33	248	31	disease	disease	NOUN
bptjm-33	248	32	and	and	CCONJ
bptjm-33	248	33	controls	control	NOUN
bptjm-33	248	34	.	.	PUNCT
bptjm-33	249	1	alzheimers	alzheimer	NOUN
bptjm-33	249	2	res	re	VERB
bptjm-33	249	3	ther	ther	ADV
bptjm-33	249	4	.	.	PUNCT
bptjm-33	250	1	2020;12(1):59	2020;12(1):59	X
bptjm-33	250	2	.	.	PUNCT
bptjm-33	251	1	published	publish	VERB
bptjm-33	251	2	2020	2020	NUM
bptjm-33	251	3	may	may	AUX
bptjm-33	251	4	15	15	NUM
bptjm-33	251	5	.	.	PUNCT
bptjm-33	252	1	doi:10.1186	doi:10.1186	PROPN
bptjm-33	252	2	/	/	SYM
bptjm-33	252	3	s13195	s13195	NOUN
bptjm-33	252	4	-	-	PUNCT
bptjm-33	252	5	020	020	NUM
bptjm-33	252	6	-	-	PUNCT
bptjm-33	252	7	00627	00627	NUM
bptjm-33	252	8	-	-	SYM
bptjm-33	252	9	0	0	NUM
bptjm-33	252	10	3	3	NUM
bptjm-33	252	11	.	.	PUNCT
bptjm-33	253	1	how	how	SCONJ
bptjm-33	253	2	is	be	AUX
bptjm-33	253	3	alzheimer	alzheimer	PROPN
bptjm-33	253	4	's	's	PART
bptjm-33	253	5	disease	disease	NOUN
bptjm-33	253	6	treated	treat	VERB
bptjm-33	253	7	?	?	PUNCT
bptjm-33	254	1	national	national	PROPN
bptjm-33	254	2	institute	institute	PROPN
bptjm-33	254	3	on	on	ADP
bptjm-33	254	4	aging	age	VERB
bptjm-33	254	5	.	.	PUNCT
bptjm-33	255	1	https://www.nia.nih.gov/health/how-alzheimersdisease-treated#:~:text=aducanumab%20is%20th	https://www.nia.nih.gov/health/how-alzheimersdisease-treated#:~:text=aducanumab%20is%20th	PROPN
bptjm-33	255	2	e%20only%20disease	e%20only%20disease	PROPN
bptjm-33	255	3	,	,	PUNCT
bptjm-33	255	4	brain%20lesions%20associat	brain%20lesions%20associat	PROPN
bptjm-33	255	5	ed%20with%20alzheimer%27s	ed%20with%20alzheimer%27s	PROPN
bptjm-33	255	6	.	.	PROPN
bptjm-33	255	7	accessed	access	VERB
bptjm-33	255	8	september	september	PROPN
bptjm-33	255	9	19	19	NUM
bptjm-33	255	10	,	,	PUNCT
bptjm-33	255	11	2022	2022	NUM
bptjm-33	255	12	.	.	PUNCT
bptjm-33	256	1	4	4	NUM
bptjm-33	256	2	.	.	X
bptjm-33	256	3	grossberg	grossberg	PROPN
bptjm-33	256	4	gt	gt	PROPN
bptjm-33	256	5	.	.	PUNCT
bptjm-33	257	1	cholinesterase	cholinesterase	PROPN
bptjm-33	257	2	inhibitors	inhibitor	NOUN
bptjm-33	257	3	for	for	ADP
bptjm-33	257	4	the	the	DET
bptjm-33	257	5	treatment	treatment	NOUN
bptjm-33	257	6	of	of	ADP
bptjm-33	257	7	alzheimer	alzheimer	PROPN
bptjm-33	257	8	's	's	PART
bptjm-33	257	9	disease	disease	NOUN
bptjm-33	257	10	:	:	PUNCT
bptjm-33	257	11	:	:	PUNCT
bptjm-33	257	12	getting	get	VERB
bptjm-33	257	13	on	on	ADP
bptjm-33	257	14	and	and	CCONJ
bptjm-33	257	15	staying	stay	VERB
bptjm-33	257	16	on	on	ADP
bptjm-33	257	17	.	.	PUNCT
bptjm-33	258	1	curr	curr	PROPN
bptjm-33	258	2	ther	ther	PROPN
bptjm-33	258	3	res	re	VERB
bptjm-33	258	4	clin	clin	PROPN
bptjm-33	258	5	exp	exp	PROPN
bptjm-33	258	6	.	.	PUNCT
bptjm-33	259	1	2003;64(4):216	2003;64(4):216	NUM
bptjm-33	259	2	-	-	SYM
bptjm-33	259	3	235	235	NUM
bptjm-33	259	4	.	.	PUNCT
bptjm-33	259	5	doi:10.1016	doi:10.1016	PROPN
bptjm-33	259	6	/	/	SYM
bptjm-33	259	7	s0011	s0011	PROPN
bptjm-33	259	8	-	-	PUNCT
bptjm-33	259	9	393x(03)00059	393x(03)00059	NUM
bptjm-33	259	10	-	-	PUNCT
bptjm-33	259	11	6	6	NUM
bptjm-33	259	12	5	5	NUM
bptjm-33	259	13	.	.	PUNCT
bptjm-33	260	1	angelucci	angelucci	PROPN
bptjm-33	261	1	f	f	PROPN
bptjm-33	261	2	,	,	PUNCT
bptjm-33	261	3	cechova	cechova	X
bptjm-33	261	4	k	k	X
bptjm-33	261	5	,	,	PUNCT
bptjm-33	261	6	valis	valis	PROPN
bptjm-33	261	7	m	m	PROPN
bptjm-33	261	8	,	,	PUNCT
bptjm-33	261	9	kuca	kuca	NOUN
bptjm-33	261	10	k	k	PROPN
bptjm-33	261	11	,	,	PUNCT
bptjm-33	261	12	zhang	zhang	PROPN
bptjm-33	261	13	b	b	PROPN
bptjm-33	261	14	,	,	PUNCT
bptjm-33	261	15	hort	hort	PROPN
bptjm-33	261	16	j.	j.	PROPN
bptjm-33	261	17	micrornas	micrornas	PROPN
bptjm-33	261	18	in	in	ADP
bptjm-33	261	19	alzheimer	alzheimer	PROPN
bptjm-33	261	20	's	's	PART
bptjm-33	261	21	disease	disease	NOUN
bptjm-33	261	22	:	:	PUNCT
bptjm-33	261	23	diagnostic	diagnostic	ADJ
bptjm-33	261	24	markers	marker	NOUN
bptjm-33	261	25	or	or	CCONJ
bptjm-33	261	26	therapeutic	therapeutic	ADJ
bptjm-33	261	27	agents	agent	NOUN
bptjm-33	261	28	?	?	PUNCT
bptjm-33	262	1	frontiers	frontier	NOUN
bptjm-33	262	2	.	.	PUNCT
bptjm-33	263	1	https://www.frontiersin.org/articles/10.3389/fph	https://www.frontiersin.org/articles/10.3389/fph	PROPN
bptjm-33	263	2	ar.2019.00665	ar.2019.00665	ADJ
bptjm-33	263	3	/	/	SYM
bptjm-33	263	4	full	full	ADJ
bptjm-33	263	5	.	.	PUNCT
bptjm-33	264	1	published	publish	VERB
bptjm-33	264	2	january	january	PROPN
bptjm-33	264	3	1	1	NUM
bptjm-33	264	4	,	,	PUNCT
bptjm-33	264	5	1ad	1ad	X
bptjm-33	264	6	.	.	PUNCT
bptjm-33	265	1	accessed	access	VERB
bptjm-33	265	2	september	september	PROPN
bptjm-33	265	3	19	19	NUM
bptjm-33	265	4	,	,	PUNCT
bptjm-33	265	5	2022	2022	NUM
bptjm-33	265	6	.	.	PUNCT
bptjm-33	266	1	6	6	NUM
bptjm-33	266	2	.	.	PUNCT
bptjm-33	266	3	wang	wang	PROPN
bptjm-33	266	4	y	y	PROPN
bptjm-33	266	5	,	,	PUNCT
bptjm-33	266	6	zhao	zhao	PROPN
bptjm-33	266	7	l	l	PROPN
bptjm-33	266	8	,	,	PUNCT
bptjm-33	266	9	kan	kan	PROPN
bptjm-33	266	10	b	b	PROPN
bptjm-33	266	11	,	,	PUNCT
bptjm-33	266	12	shi	shi	PROPN
bptjm-33	266	13	h	h	PROPN
bptjm-33	266	14	,	,	PUNCT
bptjm-33	266	15	han	han	PROPN
bptjm-33	266	16	j.	j.	PROPN
bptjm-33	266	17	mir-22	mir-22	PROPN
bptjm-33	266	18	exerts	exert	VERB
bptjm-33	266	19	anti	anti	ADJ
bptjm-33	266	20	-	-	ADJ
bptjm-33	266	21	alzheimic	alzheimic	ADJ
bptjm-33	266	22	e	e	NOUN
bptjm-33	266	23	�	�	PROPN
bptjm-33	266	24	ects	ect	VERB
bptjm-33	266	25	via	via	ADP
bptjm-33	266	26	the	the	DET
bptjm-33	266	27	regulation	regulation	NOUN
bptjm-33	266	28	of	of	ADP
bptjm-33	266	29	apoptosis	apoptosis	NOUN
bptjm-33	266	30	of	of	ADP
bptjm-33	266	31	hippocampal	hippocampal	ADJ
bptjm-33	266	32	neurons	neuron	NOUN
bptjm-33	266	33	.	.	PUNCT
bptjm-33	267	1	cell	cell	NOUN
bptjm-33	267	2	mol	mol	ADP
bptjm-33	267	3	biol	biol	PROPN
bptjm-33	267	4	.	.	PUNCT
bptjm-33	268	1	https://cellmolbiol.org/index.php/cmb/article/vi	https://cellmolbiol.org/index.php/cmb/article/vi	PROPN
bptjm-33	268	2	ew/2623/1387	ew/2623/1387	PROPN
bptjm-33	268	3	.	.	PUNCT
bptjm-33	269	1	published	publish	VERB
bptjm-33	269	2	2018	2018	NUM
bptjm-33	269	3	.	.	PUNCT
bptjm-33	270	1	accessed	access	VERB
bptjm-33	270	2	september	september	PROPN
bptjm-33	270	3	19	19	NUM
bptjm-33	270	4	,	,	PUNCT
bptjm-33	270	5	2022	2022	NUM
bptjm-33	270	6	.	.	PUNCT
bptjm-33	271	1	7	7	X
bptjm-33	271	2	.	.	X
bptjm-33	271	3	adlakha	adlakha	PROPN
bptjm-33	271	4	yk	yk	PROPN
bptjm-33	271	5	,	,	PUNCT
bptjm-33	271	6	saini	saini	PROPN
bptjm-33	271	7	n.	n.	PROPN
bptjm-33	271	8	brain	brain	NOUN
bptjm-33	271	9	micrornas	microrna	NOUN
bptjm-33	271	10	and	and	CCONJ
bptjm-33	271	11	insights	insight	NOUN
bptjm-33	271	12	into	into	ADP
bptjm-33	271	13	biological	biological	ADJ
bptjm-33	271	14	functions	function	NOUN
bptjm-33	271	15	and	and	CCONJ
bptjm-33	271	16	therapeutic	therapeutic	ADJ
bptjm-33	271	17	potential	potential	NOUN
bptjm-33	271	18	of	of	ADP
bptjm-33	271	19	brain	brain	NOUN
bptjm-33	271	20	enriched	enrich	VERB
bptjm-33	271	21	mirna-128	mirna-128	NOUN
bptjm-33	271	22	molecular	molecular	ADJ
bptjm-33	271	23	cancer	cancer	NOUN
bptjm-33	271	24	.	.	PUNCT
bptjm-33	271	25	biomed	biome	VERB
bptjm-33	271	26	central	central	ADJ
bptjm-33	271	27	.	.	PUNCT
bptjm-33	272	1	https://molecular-cancer.biomedcentral.com/articl	https://molecular-cancer.biomedcentral.com/articl	PROPN
bptjm-33	272	2	es/10.1186/1476	es/10.1186/1476	PROPN
bptjm-33	272	3	-	-	PUNCT
bptjm-33	272	4	4598	4598	NUM
bptjm-33	272	5	-	-	PUNCT
bptjm-33	272	6	13	13	NUM
bptjm-33	272	7	-	-	PUNCT
bptjm-33	272	8	33#bib1	33#bib1	NUM
bptjm-33	272	9	.	.	PUNCT
bptjm-33	273	1	published	publish	VERB
bptjm-33	273	2	february	february	PROPN
bptjm-33	273	3	21	21	NUM
bptjm-33	273	4	,	,	PUNCT
bptjm-33	273	5	2014	2014	NUM
bptjm-33	273	6	.	.	PUNCT
bptjm-33	274	1	accessed	access	VERB
bptjm-33	274	2	september	september	PROPN
bptjm-33	274	3	19	19	NUM
bptjm-33	274	4	,	,	PUNCT
bptjm-33	274	5	2022	2022	NUM
bptjm-33	274	6	.	.	PUNCT
bptjm-33	275	1	8	8	NUM
bptjm-33	275	2	.	.	X
bptjm-33	275	3	reza	reza	PROPN
bptjm-33	275	4	-	-	PUNCT
bptjm-33	275	5	zaldivar	zaldivar	NOUN
bptjm-33	275	6	ee	ee	PROPN
bptjm-33	275	7	,	,	PUNCT
bptjm-33	275	8	hernández	hernández	PROPN
bptjm-33	275	9	-	-	PUNCT
bptjm-33	275	10	sapiens	sapiens	PROPN
bptjm-33	275	11	ma	ma	PROPN
bptjm-33	275	12	,	,	PUNCT
bptjm-33	275	13	minjarez	minjarez	PROPN
bptjm-33	275	14	b	b	PROPN
bptjm-33	275	15	,	,	PUNCT
bptjm-33	275	16	et	et	PROPN
bptjm-33	275	17	al	al	PROPN
bptjm-33	275	18	.	.	PUNCT
bptjm-33	276	1	dendritic	dendritic	ADJ
bptjm-33	276	2	spine	spine	NOUN
bptjm-33	276	3	and	and	CCONJ
bptjm-33	276	4	synaptic	synaptic	ADJ
bptjm-33	276	5	plasticity	plasticity	NOUN
bptjm-33	276	6	in	in	ADP
bptjm-33	276	7	alzheimer	alzheimer	PROPN
bptjm-33	276	8	's	's	PART
bptjm-33	276	9	disease	disease	NOUN
bptjm-33	276	10	:	:	PUNCT
bptjm-33	276	11	a	a	DET
bptjm-33	276	12	focus	focus	NOUN
bptjm-33	276	13	on	on	ADP
bptjm-33	276	14	microrna	microrna	PROPN
bptjm-33	276	15	.	.	PUNCT
bptjm-33	277	1	front	front	ADJ
bptjm-33	277	2	cell	cell	NOUN
bptjm-33	277	3	dev	dev	PROPN
bptjm-33	277	4	biol	biol	NOUN
bptjm-33	277	5	.	.	PUNCT
bptjm-33	278	1	2020;8:255	2020;8:255	NUM
bptjm-33	278	2	.	.	PUNCT
bptjm-33	279	1	published	publish	VERB
bptjm-33	279	2	2020	2020	NUM
bptjm-33	279	3	may	may	AUX
bptjm-33	279	4	5	5	NUM
bptjm-33	279	5	.	.	PUNCT
bptjm-33	279	6	doi:10.3389	doi:10.3389	PROPN
bptjm-33	279	7	/	/	SYM
bptjm-33	279	8	fcell.2020.00255	fcell.2020.00255	PROPN
bptjm-33	279	9	9	9	NUM
bptjm-33	279	10	.	.	PUNCT
bptjm-33	280	1	s.	s.	PROPN
bptjm-33	280	2	kumar	kumar	PROPN
bptjm-33	280	3	,	,	PUNCT
bptjm-33	280	4	m.	m.	NOUN
bptjm-33	280	5	vijayan	vijayan	PROPN
bptjm-33	280	6	,	,	PUNCT
bptjm-33	280	7	j.s	j.s	PROPN
bptjm-33	280	8	.	.	PROPN
bptjm-33	280	9	bhatti	bhatti	PROPN
bptjm-33	280	10	,	,	PUNCT
bptjm-33	280	11	p.h	p.h	PROPN
bptjm-33	280	12	.	.	PROPN
bptjm-33	280	13	reddy	reddy	PROPN
bptjm-33	280	14	,	,	PUNCT
bptjm-33	280	15	chapter	chapter	NOUN
bptjm-33	280	16	three	three	NUM
bptjm-33	280	17	micrornas	microrna	NOUN
bptjm-33	280	18	as	as	ADP
bptjm-33	280	19	peripheral	peripheral	ADJ
bptjm-33	280	20	biomarkers	biomarker	NOUN
bptjm-33	280	21	in	in	ADP
bptjm-33	280	22	aging	aging	NOUN
bptjm-33	280	23	and	and	CCONJ
bptjm-33	280	24	age	age	NOUN
bptjm-33	280	25	-	-	PUNCT
bptjm-33	280	26	related	relate	VERB
bptjm-33	280	27	diseases	disease	NOUN
bptjm-33	280	28	,	,	PUNCT
bptjm-33	280	29	editor(s	editor(s	PROPN
bptjm-33	280	30	):	):	PUNCT
bptjm-33	280	31	p.hemachandra	p.hemachandra	NOUN
bptjm-33	280	32	reddy	reddy	PROPN
bptjm-33	280	33	,	,	PUNCT
bptjm-33	280	34	progress	progress	NOUN
bptjm-33	280	35	in	in	ADP
bptjm-33	280	36	molecular	molecular	ADJ
bptjm-33	280	37	biology	biology	NOUN
bptjm-33	280	38	and	and	CCONJ
bptjm-33	280	39	translational	translational	ADJ
bptjm-33	280	40	science	science	NOUN
bptjm-33	280	41	,	,	PUNCT
bptjm-33	280	42	academic	academic	ADJ
bptjm-33	280	43	press	press	NOUN
bptjm-33	280	44	,	,	PUNCT
bptjm-33	280	45	2017;146:47	2017;146:47	NUM
bptjm-33	280	46	-	-	SYM
bptjm-33	280	47	94	94	NUM
bptjm-33	280	48	,	,	PUNCT
bptjm-33	280	49	issn	issn	PROPN
bptjm-33	280	50	1877	1877	NUM
bptjm-33	280	51	-	-	SYM
bptjm-33	280	52	1173	1173	NUM
bptjm-33	280	53	,	,	PUNCT
bptjm-33	280	54	isbn	isbn	ADJ
bptjm-33	280	55	9780128115329	9780128115329	NUM
bptjm-33	280	56	,	,	PUNCT
bptjm-33	280	57	https://doi.org/10.1016/bs.pmbts.2016.12.013	https://doi.org/10.1016/bs.pmbts.2016.12.013	PROPN
bptjm-33	280	58	.	.	PUNCT
bptjm-33	280	59	10	10	NUM
bptjm-33	280	60	.	.	PUNCT
bptjm-33	281	1	sun	sun	PROPN
bptjm-33	281	2	x	x	PROPN
bptjm-33	281	3	,	,	PUNCT
bptjm-33	281	4	chen	chen	PROPN
bptjm-33	281	5	w	w	PROPN
bptjm-33	281	6	-	-	PROPN
bptjm-33	281	7	d	d	PROPN
bptjm-33	281	8	,	,	PUNCT
bptjm-33	281	9	wang	wang	PROPN
bptjm-33	281	10	y	y	PROPN
bptjm-33	281	11	-	-	PROPN
bptjm-33	281	12	d.	d.	PROPN
bptjm-33	281	13	β	β	NOUN
bptjm-33	281	14	-	-	PUNCT
bptjm-33	281	15	amyloid	amyloid	NOUN
bptjm-33	281	16	:	:	PUNCT
bptjm-33	281	17	the	the	DET
bptjm-33	281	18	key	key	ADJ
bptjm-33	281	19	peptide	peptide	NOUN
bptjm-33	281	20	in	in	ADP
bptjm-33	281	21	the	the	DET
bptjm-33	281	22	pathogenesis	pathogenesis	NOUN
bptjm-33	281	23	of	of	ADP
bptjm-33	281	24	alzheimer	alzheimer	PROPN
bptjm-33	281	25	's	's	PART
bptjm-33	281	26	disease	disease	NOUN
bptjm-33	281	27	.	.	PUNCT
bptjm-33	282	1	frontiers	frontier	NOUN
bptjm-33	282	2	.	.	PUNCT
bptjm-33	283	1	https://www.frontiersin.org/articles/10.3389/fp	https://www.frontiersin.org/articles/10.3389/fp	PROPN
bptjm-33	283	2	har.2015.00221	har.2015.00221	PROPN
bptjm-33	283	3	/	/	SYM
bptjm-33	283	4	full	full	ADJ
bptjm-33	283	5	.	.	PUNCT
bptjm-33	284	1	published	publish	VERB
bptjm-33	284	2	january	january	PROPN
bptjm-33	284	3	1	1	NUM
bptjm-33	284	4	,	,	PUNCT
bptjm-33	284	5	1ad	1ad	X
bptjm-33	284	6	.	.	PUNCT
bptjm-33	285	1	accessed	access	VERB
bptjm-33	285	2	october	october	PROPN
bptjm-33	285	3	3	3	NUM
bptjm-33	285	4	,	,	PUNCT
bptjm-33	285	5	2022	2022	NUM
bptjm-33	285	6	.	.	PUNCT
bptjm-33	286	1	11	11	NUM
bptjm-33	286	2	.	.	X
bptjm-33	286	3	tiwari	tiwari	PROPN
bptjm-33	286	4	s	s	PROPN
bptjm-33	286	5	,	,	PUNCT
bptjm-33	286	6	atluri	atluri	PROPN
bptjm-33	286	7	v	v	PROPN
bptjm-33	286	8	,	,	PUNCT
bptjm-33	286	9	kaushik	kaushik	PROPN
bptjm-33	286	10	a	a	PRON
bptjm-33	286	11	,	,	PUNCT
bptjm-33	286	12	yndart	yndart	PROPN
bptjm-33	286	13	a	a	PRON
bptjm-33	286	14	,	,	PUNCT
bptjm-33	286	15	nair	nair	PROPN
bptjm-33	286	16	m.	m.	PROPN
bptjm-33	286	17	alzheimer	alzheimer	PROPN
bptjm-33	286	18	's	's	PART
bptjm-33	286	19	disease	disease	NOUN
bptjm-33	286	20	:	:	PUNCT
bptjm-33	286	21	pathogenesis	pathogenesis	NOUN
bptjm-33	286	22	,	,	PUNCT
bptjm-33	286	23	diagnostics	diagnostic	NOUN
bptjm-33	286	24	,	,	PUNCT
bptjm-33	286	25	and	and	CCONJ
bptjm-33	286	26	therapeutics	therapeutic	NOUN
bptjm-33	286	27	.	.	PUNCT
bptjm-33	287	1	int	int	NOUN
bptjm-33	287	2	j	j	PROPN
bptjm-33	287	3	nanomedicine	nanomedicine	PROPN
bptjm-33	287	4	.	.	PUNCT
bptjm-33	288	1	2019;14:5541	2019;14:5541	NUM
bptjm-33	288	2	-	-	SYM
bptjm-33	288	3	5554	5554	NUM
bptjm-33	288	4	.	.	PUNCT
bptjm-33	289	1	published	publish	VERB
bptjm-33	289	2	berkeley	berkeley	PROPN
bptjm-33	289	3	pharma	pharma	PROPN
bptjm-33	289	4	tech	tech	NOUN
bptjm-33	289	5	journal	journal	NOUN
bptjm-33	289	6	of	of	ADP
bptjm-33	289	7	medicine	medicine	NOUN
bptjm-33	289	8	|	|	ADV
bptjm-33	289	9	66	66	NUM
bptjm-33	289	10	2019	2019	NUM
bptjm-33	289	11	jul	jul	PROPN
bptjm-33	289	12	19	19	NUM
bptjm-33	289	13	.	.	PUNCT
bptjm-33	289	14	doi:10.2147	doi:10.2147	PROPN
bptjm-33	289	15	/	/	SYM
bptjm-33	289	16	ijn.s200490	ijn.s200490	PROPN
bptjm-33	289	17	12	12	NUM
bptjm-33	289	18	.	.	PUNCT
bptjm-33	290	1	breijyeh	breijyeh	PROPN
bptjm-33	290	2	z	z	PROPN
bptjm-33	290	3	,	,	PUNCT
bptjm-33	290	4	karaman	karaman	PROPN
bptjm-33	290	5	r.	r.	PROPN
bptjm-33	290	6	comprehensive	comprehensive	PROPN
bptjm-33	290	7	review	review	PROPN
bptjm-33	290	8	on	on	ADP
bptjm-33	290	9	alzheimer	alzheimer	PROPN
bptjm-33	290	10	’s	’s	PART
bptjm-33	290	11	disease	disease	NOUN
bptjm-33	290	12	:	:	PUNCT
bptjm-33	290	13	causes	cause	NOUN
bptjm-33	290	14	and	and	CCONJ
bptjm-33	290	15	treatment	treatment	NOUN
bptjm-33	290	16	.	.	PUNCT
bptjm-33	291	1	molecules	molecule	NOUN
bptjm-33	291	2	.	.	PUNCT
bptjm-33	292	1	2020	2020	NUM
bptjm-33	292	2	;	;	PUNCT
bptjm-33	292	3	25(24):5789	25(24):5789	NUM
bptjm-33	292	4	.	.	X
bptjm-33	292	5	https://doi.org/10.3390/molecules25245	https://doi.org/10.3390/molecules25245	VERB
bptjm-33	292	6	789	789	NUM
bptjm-33	292	7	13	13	NUM
bptjm-33	292	8	.	.	PUNCT
bptjm-33	293	1	sen	sen	PROPN
bptjm-33	293	2	liu	liu	PROPN
bptjm-33	293	3	,	,	PUNCT
bptjm-33	293	4	min	min	PROPN
bptjm-33	293	5	fan	fan	PROPN
bptjm-33	293	6	,	,	PUNCT
bptjm-33	293	7	qiang	qiang	PROPN
bptjm-33	293	8	zheng	zheng	PROPN
bptjm-33	293	9	,	,	PUNCT
bptjm-33	293	10	shengwei	shengwei	PROPN
bptjm-33	293	11	hao	hao	PROPN
bptjm-33	293	12	,	,	PUNCT
bptjm-33	293	13	longjun	longjun	PROPN
bptjm-33	293	14	yang	yang	PROPN
bptjm-33	293	15	,	,	PUNCT
bptjm-33	293	16	qingrong	qingrong	PROPN
bptjm-33	293	17	xia	xia	PROPN
bptjm-33	293	18	,	,	PUNCT
bptjm-33	293	19	congcong	congcong	PROPN
bptjm-33	293	20	qi	qi	PROPN
bptjm-33	293	21	,	,	PUNCT
bptjm-33	293	22	jinfang	jinfang	PROPN
bptjm-33	293	23	ge	ge	PROPN
bptjm-33	293	24	,	,	PUNCT
bptjm-33	293	25	micrornas	microrna	NOUN
bptjm-33	293	26	in	in	ADP
bptjm-33	293	27	alzheimer	alzheimer	PROPN
bptjm-33	293	28	's	's	PART
bptjm-33	293	29	disease	disease	NOUN
bptjm-33	293	30	:	:	PUNCT
bptjm-33	293	31	potential	potential	ADJ
bptjm-33	293	32	diagnostic	diagnostic	ADJ
bptjm-33	293	33	markers	marker	NOUN
bptjm-33	293	34	and	and	CCONJ
bptjm-33	293	35	therapeutic	therapeutic	ADJ
bptjm-33	293	36	targets	target	NOUN
bptjm-33	293	37	,	,	PUNCT
bptjm-33	293	38	biomedicine	biomedicine	NOUN
bptjm-33	293	39	&	&	CCONJ
bptjm-33	293	40	pharmacotherapy	pharmacotherapy	NOUN
bptjm-33	293	41	,	,	PUNCT
bptjm-33	293	42	2022;148(112681	2022;148(112681	NUM
bptjm-33	293	43	)	)	PUNCT
bptjm-33	293	44	.	.	PUNCT
bptjm-33	294	1	issn	issn	PROPN
bptjm-33	294	2	0753	0753	NUM
bptjm-33	294	3	-	-	SYM
bptjm-33	294	4	3322	3322	NUM
bptjm-33	294	5	,	,	PUNCT
bptjm-33	294	6	https://doi.org/10.1016/j.biopha.2022.112681	https://doi.org/10.1016/j.biopha.2022.112681	PROPN
bptjm-33	294	7	.	.	PUNCT
bptjm-33	295	1	14	14	NUM
bptjm-33	295	2	.	.	PUNCT
bptjm-33	295	3	home	home	NOUN
bptjm-33	295	4	books	book	NOUN
bptjm-33	295	5	ncbi	ncbi	PROPN
bptjm-33	295	6	.	.	PUNCT
bptjm-33	296	1	national	national	ADJ
bptjm-33	296	2	center	center	NOUN
bptjm-33	296	3	for	for	ADP
bptjm-33	296	4	biotechnology	biotechnology	NOUN
bptjm-33	296	5	information	information	NOUN
bptjm-33	296	6	.	.	PUNCT
bptjm-33	297	1	https://www.ncbi.nlm.nih.gov/books	https://www.ncbi.nlm.nih.gov/books	PROPN
bptjm-33	297	2	.	.	PUNCT
bptjm-33	298	1	accessed	access	VERB
bptjm-33	298	2	october	october	PROPN
bptjm-33	298	3	3	3	NUM
bptjm-33	298	4	,	,	PUNCT
bptjm-33	298	5	2022	2022	NUM
bptjm-33	298	6	.	.	PUNCT
bptjm-33	299	1	15	15	NUM
bptjm-33	299	2	.	.	PUNCT
bptjm-33	299	3	breijyeh	breijyeh	PROPN
bptjm-33	299	4	z	z	PROPN
bptjm-33	299	5	,	,	PUNCT
bptjm-33	299	6	karaman	karaman	PROPN
bptjm-33	299	7	r.	r.	PROPN
bptjm-33	299	8	comprehensive	comprehensive	PROPN
bptjm-33	299	9	review	review	PROPN
bptjm-33	299	10	on	on	ADP
bptjm-33	299	11	alzheimer	alzheimer	PROPN
bptjm-33	299	12	's	's	PART
bptjm-33	299	13	disease	disease	NOUN
bptjm-33	299	14	:	:	PUNCT
bptjm-33	299	15	causes	cause	NOUN
bptjm-33	299	16	and	and	CCONJ
bptjm-33	299	17	treatment	treatment	NOUN
bptjm-33	299	18	.	.	PUNCT
bptjm-33	300	1	molecules	molecule	NOUN
bptjm-33	300	2	.	.	PUNCT
bptjm-33	301	1	2020;25(24):5789	2020;25(24):5789	X
bptjm-33	301	2	.	.	PUNCT
bptjm-33	302	1	published	publish	VERB
bptjm-33	302	2	2020	2020	NUM
bptjm-33	302	3	dec	dec	PROPN
bptjm-33	302	4	8	8	NUM
bptjm-33	302	5	.	.	PUNCT
bptjm-33	303	1	doi:10.3390	doi:10.3390	NOUN
bptjm-33	303	2	/	/	SYM
bptjm-33	304	1	molecules25245789	molecules25245789	ADJ
bptjm-33	304	2	16	16	NUM
bptjm-33	304	3	.	.	PUNCT
bptjm-33	305	1	lauretti	lauretti	PROPN
bptjm-33	305	2	e	e	PROPN
bptjm-33	305	3	,	,	PUNCT
bptjm-33	305	4	dabrowski	dabrowski	VERB
bptjm-33	305	5	k	k	NOUN
bptjm-33	305	6	,	,	PUNCT
bptjm-33	305	7	praticò	praticò	PROPN
bptjm-33	305	8	d.	d.	NOUN
bptjm-33	305	9	the	the	DET
bptjm-33	305	10	neurobiology	neurobiology	NOUN
bptjm-33	305	11	of	of	ADP
bptjm-33	305	12	non	non	ADJ
bptjm-33	305	13	-	-	ADJ
bptjm-33	305	14	coding	coding	ADJ
bptjm-33	305	15	rnas	rna	NOUN
bptjm-33	305	16	and	and	CCONJ
bptjm-33	305	17	alzheimer	alzheimer	PROPN
bptjm-33	305	18	's	's	PART
bptjm-33	305	19	disease	disease	NOUN
bptjm-33	305	20	pathogenesis	pathogenesis	NOUN
bptjm-33	305	21	:	:	PUNCT
bptjm-33	305	22	pathways	pathway	NOUN
bptjm-33	305	23	,	,	PUNCT
bptjm-33	305	24	mechanisms	mechanism	NOUN
bptjm-33	305	25	and	and	CCONJ
bptjm-33	305	26	translational	translational	ADJ
bptjm-33	305	27	opportunities	opportunity	NOUN
bptjm-33	305	28	.	.	PUNCT
bptjm-33	306	1	aging	age	VERB
bptjm-33	306	2	research	research	NOUN
bptjm-33	306	3	reviews	review	NOUN
bptjm-33	306	4	.	.	PUNCT
bptjm-33	307	1	https://www.sciencedirect.com/science/article	https://www.sciencedirect.com/science/article	PROPN
bptjm-33	307	2	/pii	/pii	PUNCT
bptjm-33	307	3	/	/	SYM
bptjm-33	307	4	s1568163721001720?via%3dihub	s1568163721001720?via%3dihub	PROPN
bptjm-33	307	5	.	.	PUNCT
bptjm-33	308	1	published	publish	VERB
bptjm-33	308	2	august	august	PROPN
bptjm-33	308	3	9	9	NUM
bptjm-33	308	4	,	,	PUNCT
bptjm-33	308	5	2021	2021	NUM
bptjm-33	308	6	.	.	PUNCT
bptjm-33	309	1	accessed	access	VERB
bptjm-33	309	2	october	october	PROPN
bptjm-33	309	3	3	3	NUM
bptjm-33	309	4	,	,	PUNCT
bptjm-33	309	5	2022	2022	NUM
bptjm-33	309	6	.	.	PUNCT
bptjm-33	310	1	17	17	NUM
bptjm-33	310	2	.	.	PUNCT
bptjm-33	311	1	ishida	ishida	PROPN
bptjm-33	311	2	m	m	PROPN
bptjm-33	311	3	,	,	PUNCT
bptjm-33	311	4	selaru	selaru	PROPN
bptjm-33	311	5	fm	fm	PROPN
bptjm-33	311	6	.	.	PROPN
bptjm-33	311	7	mirna	mirna	PROPN
bptjm-33	311	8	-	-	PUNCT
bptjm-33	311	9	based	base	VERB
bptjm-33	311	10	therapeutic	therapeutic	ADJ
bptjm-33	311	11	strategies	strategy	NOUN
bptjm-33	311	12	.	.	PUNCT
bptjm-33	312	1	curr	curr	PROPN
bptjm-33	312	2	anesthesiol	anesthesiol	PROPN
bptjm-33	312	3	rep	rep	PROPN
bptjm-33	312	4	.	.	PROPN
bptjm-33	312	5	2013;1(1):63	2013;1(1):63	NUM
bptjm-33	312	6	-	-	SYM
bptjm-33	312	7	70	70	NUM
bptjm-33	312	8	.	.	PUNCT
bptjm-33	313	1	doi:10.1007	doi:10.1007	VERB
bptjm-33	313	2	/	/	SYM
bptjm-33	313	3	s40139	s40139	PROPN
bptjm-33	313	4	-	-	PUNCT
bptjm-33	313	5	012	012	NUM
bptjm-33	313	6	-	-	PUNCT
bptjm-33	313	7	0004	0004	NUM
bptjm-33	313	8	-	-	SYM
bptjm-33	313	9	5	5	NUM
bptjm-33	313	10	18	18	NUM
bptjm-33	313	11	.	.	PUNCT
bptjm-33	314	1	jiang	jiang	PROPN
bptjm-33	314	2	h	h	PROPN
bptjm-33	314	3	,	,	PUNCT
bptjm-33	314	4	liu	liu	PROPN
bptjm-33	314	5	j	j	PROPN
bptjm-33	314	6	,	,	PUNCT
bptjm-33	314	7	guo	guo	PROPN
bptjm-33	314	8	s	s	PROPN
bptjm-33	314	9	,	,	PUNCT
bptjm-33	314	10	et	et	PROPN
bptjm-33	314	11	al	al	PROPN
bptjm-33	314	12	.	.	PUNCT
bptjm-33	315	1	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	315	2	rescues	rescue	VERB
bptjm-33	315	3	cognition	cognition	NOUN
bptjm-33	315	4	in	in	ADP
bptjm-33	315	5	alzheimer	alzheimer	PROPN
bptjm-33	315	6	's	's	PART
bptjm-33	315	7	disease	disease	NOUN
bptjm-33	315	8	by	by	ADP
bptjm-33	315	9	reducing	reduce	VERB
bptjm-33	315	10	tau	tau	PROPN
bptjm-33	315	11	phosphorylation	phosphorylation	NOUN
bptjm-33	315	12	and	and	CCONJ
bptjm-33	315	13	apoptosis	apoptosis	NOUN
bptjm-33	315	14	via	via	ADP
bptjm-33	315	15	gsk-3β	gsk-3β	ADJ
bptjm-33	315	16	signaling	signal	VERB
bptjm-33	315	17	pathways	pathway	NOUN
bptjm-33	315	18	.	.	PUNCT
bptjm-33	316	1	molecular	molecular	ADJ
bptjm-33	316	2	therapy	therapy	NOUN
bptjm-33	316	3	nucleic	nucleic	ADJ
bptjm-33	316	4	acids	acid	NOUN
bptjm-33	316	5	.	.	PUNCT
bptjm-33	317	1	https://www.sciencedirect.com/science/article/pii/	https://www.sciencedirect.com/science/article/pii/	X
bptjm-33	318	1	s2162253122000841	s2162253122000841	PROPN
bptjm-33	318	2	.	.	PUNCT
bptjm-33	319	1	published	publish	VERB
bptjm-33	319	2	april	april	PROPN
bptjm-33	319	3	18	18	NUM
bptjm-33	319	4	,	,	PUNCT
bptjm-33	319	5	2022	2022	NUM
bptjm-33	319	6	.	.	PUNCT
bptjm-33	320	1	accessed	access	VERB
bptjm-33	320	2	october	october	PROPN
bptjm-33	320	3	3	3	NUM
bptjm-33	320	4	,	,	PUNCT
bptjm-33	320	5	2022	2022	NUM
bptjm-33	320	6	.	.	PUNCT
bptjm-33	321	1	19	19	NUM
bptjm-33	321	2	.	.	X
bptjm-33	322	1	higaki	higaki	PROPN
bptjm-33	322	2	s	s	PROPN
bptjm-33	322	3	,	,	PUNCT
bptjm-33	322	4	muramatsu	muramatsu	PROPN
bptjm-33	322	5	m	m	PROPN
bptjm-33	322	6	,	,	PUNCT
bptjm-33	322	7	matsuda	matsuda	PROPN
bptjm-33	322	8	a	a	X
bptjm-33	322	9	,	,	PUNCT
bptjm-33	322	10	et	et	PROPN
bptjm-33	322	11	al	al	PROPN
bptjm-33	322	12	.	.	PUNCT
bptjm-33	322	13	defensive	defensive	PROPN
bptjm-33	323	1	e	e	X
bptjm-33	323	2	�	�	NOUN
bptjm-33	323	3	ect	ect	NOUN
bptjm-33	323	4	of	of	ADP
bptjm-33	323	5	microrna-200b	microrna-200b	PROPN
bptjm-33	323	6	/	/	SYM
bptjm-33	323	7	c	c	NOUN
bptjm-33	323	8	against	against	ADP
bptjm-33	323	9	amyloid	amyloid	NOUN
bptjm-33	323	10	-	-	PUNCT
bptjm-33	323	11	beta	beta	NOUN
bptjm-33	323	12	peptide	peptide	NOUN
bptjm-33	323	13	-	-	PUNCT
bptjm-33	323	14	induced	induce	VERB
bptjm-33	323	15	toxicity	toxicity	NOUN
bptjm-33	323	16	in	in	ADP
bptjm-33	323	17	alzheimer	alzheimer	PROPN
bptjm-33	323	18	's	's	PART
bptjm-33	323	19	disease	disease	NOUN
bptjm-33	323	20	models	model	NOUN
bptjm-33	323	21	.	.	PUNCT
bptjm-33	324	1	plos	plos	PROPN
bptjm-33	324	2	one	one	NUM
bptjm-33	324	3	.	.	PUNCT
bptjm-33	325	1	https://journals.plos.org/plosone/article?id=10.13	https://journals.plos.org/plosone/article?id=10.13	NUM
bptjm-33	325	2	71%2fjournal.pone.0196929	71%2fjournal.pone.0196929	NOUN
bptjm-33	325	3	.	.	PUNCT
bptjm-33	325	4	accessed	access	VERB
bptjm-33	325	5	october	october	PROPN
bptjm-33	325	6	3	3	NUM
bptjm-33	325	7	,	,	PUNCT
bptjm-33	325	8	2022	2022	NUM
bptjm-33	325	9	.	.	PUNCT
bptjm-33	326	1	20	20	NUM
bptjm-33	326	2	.	.	PUNCT
bptjm-33	327	1	an	an	DET
bptjm-33	327	2	f	f	NOUN
bptjm-33	327	3	,	,	PUNCT
bptjm-33	327	4	gong	gong	NOUN
bptjm-33	327	5	g	g	PROPN
bptjm-33	327	6	,	,	PUNCT
bptjm-33	327	7	wang	wang	PROPN
bptjm-33	327	8	y	y	PROPN
bptjm-33	327	9	,	,	PUNCT
bptjm-33	327	10	bian	bian	PROPN
bptjm-33	327	11	m	m	PROPN
bptjm-33	327	12	,	,	PUNCT
bptjm-33	327	13	yu	yu	PROPN
bptjm-33	327	14	l	l	PROPN
bptjm-33	327	15	,	,	PUNCT
bptjm-33	327	16	wei	wei	PROPN
bptjm-33	327	17	c.	c.	PROPN
bptjm-33	327	18	mir-124	mir-124	PROPN
bptjm-33	327	19	acts	act	VERB
bptjm-33	327	20	as	as	ADP
bptjm-33	327	21	a	a	DET
bptjm-33	327	22	target	target	NOUN
bptjm-33	327	23	for	for	ADP
bptjm-33	327	24	alzheimer	alzheimer	PROPN
bptjm-33	327	25	's	's	PART
bptjm-33	327	26	disease	disease	NOUN
bptjm-33	327	27	by	by	ADP
bptjm-33	327	28	regulating	regulate	VERB
bptjm-33	327	29	bace1	bace1	NOUN
bptjm-33	328	1	[	[	X
bptjm-33	328	2	published	publish	VERB
bptjm-33	328	3	correction	correction	NOUN
bptjm-33	328	4	appears	appear	VERB
bptjm-33	328	5	in	in	ADP
bptjm-33	328	6	oncotarget	oncotarget	NOUN
bptjm-33	328	7	.	.	PUNCT
bptjm-33	329	1	2018	2018	NUM
bptjm-33	329	2	may	may	AUX
bptjm-33	329	3	15;9(37):24871	15;9(37):24871	NUM
bptjm-33	329	4	]	]	PUNCT
bptjm-33	329	5	.	.	PUNCT
bptjm-33	330	1	oncotarget	oncotarget	NOUN
bptjm-33	330	2	.	.	PUNCT
bptjm-33	331	1	2017;8(69):114065	2017;8(69):114065	NUM
bptjm-33	331	2	-	-	SYM
bptjm-33	331	3	114071	114071	NUM
bptjm-33	331	4	.	.	PUNCT
bptjm-33	332	1	published	publish	VERB
bptjm-33	332	2	2017	2017	NUM
bptjm-33	332	3	dec	dec	PROPN
bptjm-33	332	4	9	9	NUM
bptjm-33	332	5	.	.	PUNCT
bptjm-33	332	6	doi:10.18632	doi:10.18632	PROPN
bptjm-33	332	7	/	/	SYM
bptjm-33	332	8	oncotarget.23119	oncotarget.23119	PROPN
bptjm-33	332	9	21	21	NUM
bptjm-33	332	10	.	.	PUNCT
bptjm-33	333	1	ansari	ansari	PROPN
bptjm-33	333	2	a	a	PROPN
bptjm-33	333	3	,	,	PUNCT
bptjm-33	333	4	ma	ma	PROPN
bptjm-33	333	5	�	�	PROPN
bptjm-33	333	6	oletti	oletti	PROPN
bptjm-33	333	7	e	e	NOUN
bptjm-33	333	8	,	,	PUNCT
bptjm-33	333	9	milanesi	milanesi	NOUN
bptjm-33	333	10	e	e	NOUN
bptjm-33	333	11	,	,	PUNCT
bptjm-33	333	12	et	et	PROPN
bptjm-33	333	13	al	al	PROPN
bptjm-33	333	14	.	.	PROPN
bptjm-33	334	1	mir-146a	mir-146a	PROPN
bptjm-33	334	2	and	and	CCONJ
bptjm-33	334	3	mir-181a	mir-181a	NOUN
bptjm-33	334	4	are	be	AUX
bptjm-33	334	5	involved	involve	VERB
bptjm-33	334	6	in	in	ADP
bptjm-33	334	7	the	the	DET
bptjm-33	334	8	progression	progression	NOUN
bptjm-33	334	9	of	of	ADP
bptjm-33	334	10	mild	mild	ADJ
bptjm-33	334	11	cognitive	cognitive	ADJ
bptjm-33	334	12	impairment	impairment	NOUN
bptjm-33	334	13	to	to	ADP
bptjm-33	334	14	alzheimer	alzheimer	PROPN
bptjm-33	334	15	's	's	PART
bptjm-33	334	16	disease	disease	NOUN
bptjm-33	334	17	.	.	PUNCT
bptjm-33	335	1	neurobiology	neurobiology	NOUN
bptjm-33	335	2	of	of	ADP
bptjm-33	335	3	aging	aging	NOUN
bptjm-33	335	4	.	.	PUNCT
bptjm-33	336	1	https://www.sciencedirect.com/science/article/abs	https://www.sciencedirect.com/science/article/abs	X
bptjm-33	336	2	/pii	/pii	PUNCT
bptjm-33	336	3	/	/	SYM
bptjm-33	336	4	s0197458019301873	s0197458019301873	PROPN
bptjm-33	336	5	.	.	PROPN
bptjm-33	337	1	published	publish	VERB
bptjm-33	337	2	june	june	PROPN
bptjm-33	337	3	21	21	NUM
bptjm-33	337	4	,	,	PUNCT
bptjm-33	337	5	2019	2019	NUM
bptjm-33	337	6	.	.	PUNCT
bptjm-33	338	1	accessed	access	VERB
bptjm-33	338	2	october	october	PROPN
bptjm-33	338	3	3	3	NUM
bptjm-33	338	4	,	,	PUNCT
bptjm-33	338	5	2022	2022	NUM
bptjm-33	338	6	.	.	PUNCT
bptjm-33	339	1	22	22	NUM
bptjm-33	339	2	.	.	PUNCT
bptjm-33	340	1	otsuka	otsuka	PROPN
bptjm-33	340	2	k	k	PROPN
bptjm-33	340	3	,	,	PUNCT
bptjm-33	340	4	yamamoto	yamamoto	PROPN
bptjm-33	340	5	y	y	PROPN
bptjm-33	340	6	,	,	PUNCT
bptjm-33	340	7	ochiya	ochiya	PROPN
bptjm-33	340	8	t.	t.	PROPN
bptjm-33	340	9	regulatory	regulatory	ADJ
bptjm-33	340	10	role	role	NOUN
bptjm-33	340	11	of	of	ADP
bptjm-33	340	12	resveratrol	resveratrol	NOUN
bptjm-33	340	13	,	,	PUNCT
bptjm-33	340	14	a	a	DET
bptjm-33	340	15	microrna	microrna	PROPN
bptjm-33	340	16	-	-	PUNCT
bptjm-33	340	17	controlling	control	VERB
bptjm-33	340	18	compound	compound	NOUN
bptjm-33	340	19	,	,	PUNCT
bptjm-33	340	20	in	in	ADP
bptjm-33	340	21	hnrnpa1	hnrnpa1	NOUN
bptjm-33	340	22	expression	expression	NOUN
bptjm-33	340	23	,	,	PUNCT
bptjm-33	340	24	which	which	PRON
bptjm-33	340	25	is	be	AUX
bptjm-33	340	26	associated	associate	VERB
bptjm-33	340	27	with	with	ADP
bptjm-33	340	28	poor	poor	ADJ
bptjm-33	340	29	prognosis	prognosis	NOUN
bptjm-33	340	30	in	in	ADP
bptjm-33	340	31	breast	breast	NOUN
bptjm-33	340	32	cancer	cancer	NOUN
bptjm-33	340	33	.	.	PUNCT
bptjm-33	341	1	oncotarget	oncotarget	NOUN
bptjm-33	341	2	.	.	PUNCT
bptjm-33	342	1	2018;9(37):24718	2018;9(37):24718	NUM
bptjm-33	342	2	-	-	SYM
bptjm-33	342	3	24730	24730	NUM
bptjm-33	342	4	.	.	PUNCT
bptjm-33	343	1	published	publish	VERB
bptjm-33	343	2	2018	2018	NUM
bptjm-33	343	3	may	may	AUX
bptjm-33	343	4	15	15	NUM
bptjm-33	343	5	.	.	PUNCT
bptjm-33	344	1	doi:10.18632	doi:10.18632	PROPN
bptjm-33	344	2	/	/	SYM
bptjm-33	344	3	oncotarget.25339	oncotarget.25339	PROPN
bptjm-33	344	4	23	23	NUM
bptjm-33	344	5	.	.	PUNCT
bptjm-33	344	6	dilsiz	dilsiz	ADJ
bptjm-33	344	7	n.	n.	ADJ
bptjm-33	344	8	role	role	NOUN
bptjm-33	344	9	of	of	ADP
bptjm-33	344	10	exosomes	exosome	NOUN
bptjm-33	344	11	and	and	CCONJ
bptjm-33	344	12	exosomal	exosomal	ADJ
bptjm-33	344	13	berkeley	berkeley	PROPN
bptjm-33	344	14	pharma	pharma	PROPN
bptjm-33	344	15	tech	tech	NOUN
bptjm-33	344	16	journal	journal	NOUN
bptjm-33	344	17	of	of	ADP
bptjm-33	344	18	medicine	medicine	NOUN
bptjm-33	344	19	|	|	ADV
bptjm-33	344	20	67	67	NUM
bptjm-33	344	21	micrornas	microrna	NOUN
bptjm-33	344	22	in	in	ADP
bptjm-33	344	23	cancer	cancer	NOUN
bptjm-33	344	24	.	.	PUNCT
bptjm-33	345	1	future	future	ADJ
bptjm-33	345	2	sci	sci	PROPN
bptjm-33	345	3	oa	oa	INTJ
bptjm-33	345	4	.	.	PUNCT
bptjm-33	346	1	2020;6(4):fso465	2020;6(4):fso465	NUM
bptjm-33	346	2	.	.	PUNCT
bptjm-33	347	1	published	publish	VERB
bptjm-33	347	2	2020	2020	NUM
bptjm-33	347	3	feb	feb	PROPN
bptjm-33	347	4	26	26	NUM
bptjm-33	347	5	.	.	PUNCT
bptjm-33	348	1	doi:10.2144	doi:10.2144	ADJ
bptjm-33	348	2	/	/	SYM
bptjm-33	348	3	fsoa-2019	fsoa-2019	NOUN
bptjm-33	348	4	-	-	PUNCT
bptjm-33	348	5	0116	0116	NUM
bptjm-33	348	6	24	24	NUM
bptjm-33	348	7	.	.	PUNCT
bptjm-33	349	1	wang	wang	PROPN
bptjm-33	349	2	m	m	PROPN
bptjm-33	349	3	,	,	PUNCT
bptjm-33	349	4	qin	qin	PROPN
bptjm-33	349	5	l	l	PROPN
bptjm-33	349	6	,	,	PUNCT
bptjm-33	349	7	tang	tang	PROPN
bptjm-33	349	8	b.	b.	PROPN
bptjm-33	349	9	micrornas	micrornas	PROPN
bptjm-33	349	10	in	in	ADP
bptjm-33	349	11	alzheimer	alzheimer	PROPN
bptjm-33	349	12	's	's	PART
bptjm-33	349	13	disease	disease	NOUN
bptjm-33	349	14	.	.	PUNCT
bptjm-33	350	1	front	front	ADJ
bptjm-33	350	2	genet	genet	PROPN
bptjm-33	350	3	.	.	PUNCT
bptjm-33	351	1	2019;10:153	2019;10:153	X
bptjm-33	351	2	.	.	PUNCT
bptjm-33	352	1	published	publish	VERB
bptjm-33	352	2	2019	2019	NUM
bptjm-33	352	3	mar	mar	PROPN
bptjm-33	352	4	1	1	NUM
bptjm-33	352	5	.	.	PUNCT
bptjm-33	352	6	doi:10.3389	doi:10.3389	PROPN
bptjm-33	352	7	/	/	SYM
bptjm-33	352	8	fgene.2019.00153	fgene.2019.00153	ADJ
bptjm-33	352	9	25	25	NUM
bptjm-33	352	10	.	.	PUNCT
bptjm-33	352	11	de	de	PROPN
bptjm-33	352	12	d	d	PROPN
bptjm-33	352	13	,	,	PUNCT
bptjm-33	352	14	mukherjee	mukherjee	PROPN
bptjm-33	352	15	i	i	PROPN
bptjm-33	352	16	,	,	PUNCT
bptjm-33	352	17	guha	guha	PROPN
bptjm-33	352	18	s	s	PROPN
bptjm-33	352	19	,	,	PUNCT
bptjm-33	352	20	et	et	PROPN
bptjm-33	352	21	al	al	PROPN
bptjm-33	352	22	.	.	PUNCT
bptjm-33	353	1	rheb	rheb	ADJ
bptjm-33	353	2	-	-	PUNCT
bptjm-33	353	3	mtor	mtor	NOUN
bptjm-33	353	4	activation	activation	NOUN
bptjm-33	353	5	rescues	rescue	VERB
bptjm-33	353	6	aβ	aβ	ADV
bptjm-33	353	7	-	-	PUNCT
bptjm-33	353	8	induced	induced	ADJ
bptjm-33	353	9	cognitive	cognitive	ADJ
bptjm-33	353	10	impairment	impairment	NOUN
bptjm-33	353	11	and	and	CCONJ
bptjm-33	353	12	memory	memory	NOUN
bptjm-33	353	13	function	function	NOUN
bptjm-33	353	14	by	by	ADP
bptjm-33	353	15	restoring	restore	VERB
bptjm-33	353	16	mir-146	mir-146	NOUN
bptjm-33	353	17	activity	activity	NOUN
bptjm-33	353	18	in	in	ADP
bptjm-33	353	19	glial	glial	ADJ
bptjm-33	353	20	cells	cell	NOUN
bptjm-33	353	21	.	.	PUNCT
bptjm-33	354	1	molecular	molecular	ADJ
bptjm-33	354	2	therapy	therapy	NOUN
bptjm-33	354	3	nucleic	nucleic	ADJ
bptjm-33	354	4	acids	acid	NOUN
bptjm-33	354	5	.	.	PUNCT
bptjm-33	355	1	https://www.sciencedirect.com/science/article/	https://www.sciencedirect.com/science/article/	PROPN
bptjm-33	355	2	pii	pii	PROPN
bptjm-33	355	3	/	/	SYM
bptjm-33	355	4	s2162253121001025	s2162253121001025	PROPN
bptjm-33	355	5	.	.	PUNCT
bptjm-33	356	1	published	publish	VERB
bptjm-33	356	2	april	april	PROPN
bptjm-33	356	3	24	24	NUM
bptjm-33	356	4	,	,	PUNCT
bptjm-33	356	5	2021	2021	NUM
bptjm-33	356	6	.	.	PUNCT
bptjm-33	357	1	accessed	access	VERB
bptjm-33	357	2	october	october	PROPN
bptjm-33	357	3	3	3	NUM
bptjm-33	357	4	,	,	PUNCT
bptjm-33	357	5	2022	2022	NUM
bptjm-33	357	6	.	.	PUNCT
bptjm-33	358	1	26	26	NUM
bptjm-33	358	2	.	.	PUNCT
bptjm-33	359	1	barros	barro	NOUN
bptjm-33	359	2	-	-	PUNCT
bptjm-33	359	3	viegas	viegas	NOUN
bptjm-33	359	4	at	at	ADP
bptjm-33	359	5	,	,	PUNCT
bptjm-33	359	6	carmona	carmona	VERB
bptjm-33	359	7	v	v	NOUN
bptjm-33	359	8	,	,	PUNCT
bptjm-33	359	9	ferreiro	ferreiro	NOUN
bptjm-33	359	10	e	e	NOUN
bptjm-33	359	11	,	,	PUNCT
bptjm-33	359	12	et	et	PROPN
bptjm-33	359	13	al	al	PROPN
bptjm-33	359	14	.	.	PUNCT
bptjm-33	359	15	mirna-31	mirna-31	PROPN
bptjm-33	359	16	improves	improve	VERB
bptjm-33	359	17	cognition	cognition	NOUN
bptjm-33	359	18	and	and	CCONJ
bptjm-33	359	19	abolishes	abolish	VERB
bptjm-33	359	20	amyloid	amyloid	NOUN
bptjm-33	359	21	-	-	PUNCT
bptjm-33	359	22	β	β	X
bptjm-33	359	23	pathology	pathology	NOUN
bptjm-33	359	24	by	by	ADP
bptjm-33	359	25	targeting	target	VERB
bptjm-33	359	26	app	app	NOUN
bptjm-33	359	27	and	and	CCONJ
bptjm-33	359	28	bace1	bace1	NOUN
bptjm-33	359	29	in	in	ADP
bptjm-33	359	30	an	an	DET
bptjm-33	359	31	animal	animal	NOUN
bptjm-33	359	32	model	model	NOUN
bptjm-33	359	33	of	of	ADP
bptjm-33	359	34	alzheimer	alzheimer	PROPN
bptjm-33	359	35	's	's	PART
bptjm-33	359	36	disease	disease	NOUN
bptjm-33	359	37	.	.	PUNCT
bptjm-33	360	1	molecular	molecular	ADJ
bptjm-33	360	2	therapy	therapy	NOUN
bptjm-33	360	3	nucleic	nucleic	ADJ
bptjm-33	360	4	acids	acid	NOUN
bptjm-33	360	5	.	.	PUNCT
bptjm-33	361	1	https://www.cell.com/molecular-therapy-family/nu	https://www.cell.com/molecular-therapy-family/nu	PROPN
bptjm-33	361	2	cleic	cleic	VERB
bptjm-33	361	3	-	-	PUNCT
bptjm-33	361	4	acids	acid	NOUN
bptjm-33	361	5	/	/	SYM
bptjm-33	361	6	fulltext	fulltext	ADJ
bptjm-33	361	7	/	/	SYM
bptjm-33	361	8	s2162	s2162	PROPN
bptjm-33	361	9	-	-	PUNCT
bptjm-33	361	10	2531(20)30045	2531(20)30045	NUM
bptjm-33	361	11	-	-	PUNCT
bptjm-33	361	12	7	7	NUM
bptjm-33	361	13	.	.	PUNCT
bptjm-33	361	14	published	publish	VERB
bptjm-33	361	15	january	january	PROPN
bptjm-33	361	16	17	17	NUM
bptjm-33	361	17	,	,	PUNCT
bptjm-33	361	18	2020	2020	NUM
bptjm-33	361	19	.	.	PUNCT
bptjm-33	362	1	accessed	access	VERB
bptjm-33	362	2	october	october	PROPN
bptjm-33	362	3	3	3	NUM
bptjm-33	362	4	,	,	PUNCT
bptjm-33	362	5	2022	2022	NUM
bptjm-33	362	6	.	.	PUNCT
bptjm-33	363	1	27	27	NUM
bptjm-33	363	2	.	.	PUNCT
bptjm-33	364	1	li	li	PROPN
bptjm-33	364	2	p	p	PROPN
bptjm-33	364	3	,	,	PUNCT
bptjm-33	364	4	xu	xu	PROPN
bptjm-33	364	5	y	y	PROPN
bptjm-33	364	6	,	,	PUNCT
bptjm-33	364	7	wang	wang	PROPN
bptjm-33	364	8	b	b	PROPN
bptjm-33	364	9	,	,	PUNCT
bptjm-33	364	10	huang	huang	PROPN
bptjm-33	364	11	j	j	PROPN
bptjm-33	364	12	,	,	PUNCT
bptjm-33	364	13	li	li	PROPN
bptjm-33	364	14	q.	q.	PROPN
bptjm-33	364	15	mir-34a-5p	mir-34a-5p	PROPN
bptjm-33	364	16	and	and	CCONJ
bptjm-33	364	17	mir-125b-5p	mir-125b-5p	PROPN
bptjm-33	364	18	attenuate	attenuate	VERB
bptjm-33	364	19	aβ	aβ	ADV
bptjm-33	364	20	-	-	PUNCT
bptjm-33	364	21	induced	induce	VERB
bptjm-33	364	22	neurotoxicity	neurotoxicity	NOUN
bptjm-33	364	23	through	through	ADP
bptjm-33	364	24	targeting	target	VERB
bptjm-33	364	25	bace1	bace1	PROPN
bptjm-33	364	26	.	.	PUNCT
bptjm-33	365	1	j	j	PROPN
bptjm-33	365	2	neurol	neurol	PROPN
bptjm-33	365	3	sci	sci	PROPN
bptjm-33	365	4	.	.	PROPN
bptjm-33	365	5	2020;413:116793	2020;413:116793	NUM
bptjm-33	365	6	.	.	PUNCT
bptjm-33	366	1	doi:10.1016	doi:10.1016	PROPN
bptjm-33	366	2	/	/	SYM
bptjm-33	366	3	j.jns.2020.116793	j.jns.2020.116793	PROPN
bptjm-33	366	4	28	28	NUM
bptjm-33	366	5	.	.	PUNCT
bptjm-33	367	1	patel	patel	PROPN
bptjm-33	367	2	n	n	PROPN
bptjm-33	367	3	,	,	PUNCT
bptjm-33	367	4	hoang	hoang	PROPN
bptjm-33	367	5	d	d	PROPN
bptjm-33	367	6	,	,	PUNCT
bptjm-33	367	7	miller	miller	PROPN
bptjm-33	367	8	n	n	CCONJ
bptjm-33	367	9	,	,	PUNCT
bptjm-33	367	10	et	et	PROPN
bptjm-33	367	11	al	al	PROPN
bptjm-33	367	12	.	.	PROPN
bptjm-33	367	13	micrornas	microrna	NOUN
bptjm-33	367	14	can	can	AUX
bptjm-33	367	15	regulate	regulate	VERB
bptjm-33	367	16	human	human	ADJ
bptjm-33	367	17	app	app	NOUN
bptjm-33	367	18	levels	level	NOUN
bptjm-33	367	19	molecular	molecular	ADJ
bptjm-33	367	20	neurodegeneration	neurodegeneration	NOUN
bptjm-33	367	21	.	.	PUNCT
bptjm-33	368	1	biomed	biome	VERB
bptjm-33	368	2	central	central	ADJ
bptjm-33	368	3	.	.	PUNCT
bptjm-33	369	1	https://molecularneurodegeneration.biomedcent	https://molecularneurodegeneration.biomedcent	PROPN
bptjm-33	369	2	ral.com/articles/10.1186/1750-1326-3-10	ral.com/articles/10.1186/1750-1326-3-10	PROPN
bptjm-33	369	3	.	.	PROPN
bptjm-33	369	4	published	publish	VERB
bptjm-33	369	5	august	august	PROPN
bptjm-33	369	6	6	6	NUM
bptjm-33	369	7	,	,	PUNCT
bptjm-33	369	8	2008	2008	NUM
bptjm-33	369	9	.	.	PUNCT
bptjm-33	370	1	accessed	access	VERB
bptjm-33	370	2	october	october	PROPN
bptjm-33	370	3	3	3	NUM
bptjm-33	370	4	,	,	PUNCT
bptjm-33	370	5	2022	2022	NUM
bptjm-33	370	6	.	.	PUNCT
bptjm-33	371	1	29	29	NUM
bptjm-33	371	2	.	.	PUNCT
bptjm-33	372	1	long	long	PROPN
bptjm-33	372	2	jm	jm	PROPN
bptjm-33	372	3	,	,	PUNCT
bptjm-33	372	4	maloney	maloney	PROPN
bptjm-33	372	5	b	b	PROPN
bptjm-33	372	6	,	,	PUNCT
bptjm-33	372	7	rogers	rogers	PROPN
bptjm-33	372	8	jt	jt	PROPN
bptjm-33	372	9	,	,	PUNCT
bptjm-33	372	10	lahiri	lahiri	PROPN
bptjm-33	372	11	dk	dk	PROPN
bptjm-33	372	12	.	.	PROPN
bptjm-33	372	13	novel	novel	PROPN
bptjm-33	372	14	upregulation	upregulation	NOUN
bptjm-33	372	15	of	of	ADP
bptjm-33	372	16	amyloid	amyloid	NOUN
bptjm-33	372	17	-	-	PUNCT
bptjm-33	372	18	β	β	NOUN
bptjm-33	372	19	precursor	precursor	NOUN
bptjm-33	372	20	protein	protein	NOUN
bptjm-33	372	21	(	(	PUNCT
bptjm-33	372	22	app	app	PROPN
bptjm-33	372	23	)	)	PUNCT
bptjm-33	372	24	by	by	ADP
bptjm-33	372	25	microrna-346	microrna-346	NOUN
bptjm-33	372	26	via	via	ADP
bptjm-33	372	27	targeting	target	VERB
bptjm-33	372	28	of	of	ADP
bptjm-33	372	29	app	app	PROPN
bptjm-33	372	30	mrna	mrna	PROPN
bptjm-33	372	31	5′-untranslated	5′-untranslated	PROPN
bptjm-33	372	32	region	region	NOUN
bptjm-33	372	33	:	:	PUNCT
bptjm-33	372	34	implications	implication	NOUN
bptjm-33	372	35	in	in	ADP
bptjm-33	372	36	alzheimer	alzheimer	PROPN
bptjm-33	372	37	's	's	PART
bptjm-33	372	38	disease	disease	NOUN
bptjm-33	372	39	.	.	PUNCT
bptjm-33	373	1	nature	nature	NOUN
bptjm-33	373	2	news	news	PROPN
bptjm-33	373	3	.	.	PUNCT
bptjm-33	374	1	https://www.nature.com/articles/s41380-018-02	https://www.nature.com/articles/s41380-018-02	ADJ
bptjm-33	374	2	66	66	NUM
bptjm-33	374	3	-	-	PUNCT
bptjm-33	374	4	3#citeas	3#citeas	NUM
bptjm-33	374	5	.	.	PUNCT
bptjm-33	375	1	published	publish	VERB
bptjm-33	375	2	november	november	PROPN
bptjm-33	375	3	23	23	NUM
bptjm-33	375	4	,	,	PUNCT
bptjm-33	375	5	2018	2018	NUM
bptjm-33	375	6	.	.	PUNCT
bptjm-33	376	1	accessed	access	VERB
bptjm-33	376	2	october	october	PROPN
bptjm-33	376	3	3	3	NUM
bptjm-33	376	4	,	,	PUNCT
bptjm-33	376	5	2022	2022	NUM
bptjm-33	376	6	.	.	PUNCT
bptjm-33	377	1	30	30	NUM
bptjm-33	377	2	.	.	PUNCT
bptjm-33	378	1	jiang	jiang	PROPN
bptjm-33	378	2	h	h	PROPN
bptjm-33	378	3	,	,	PUNCT
bptjm-33	378	4	liu	liu	PROPN
bptjm-33	378	5	j	j	PROPN
bptjm-33	378	6	,	,	PUNCT
bptjm-33	378	7	guo	guo	PROPN
bptjm-33	378	8	s	s	PROPN
bptjm-33	378	9	,	,	PUNCT
bptjm-33	378	10	et	et	PROPN
bptjm-33	378	11	al	al	PROPN
bptjm-33	378	12	.	.	PUNCT
bptjm-33	379	1	mir-23b-3p	mir-23b-3p	PROPN
bptjm-33	379	2	rescues	rescue	VERB
bptjm-33	379	3	cognition	cognition	NOUN
bptjm-33	379	4	in	in	ADP
bptjm-33	379	5	alzheimer	alzheimer	PROPN
bptjm-33	379	6	's	's	PART
bptjm-33	379	7	disease	disease	NOUN
bptjm-33	379	8	by	by	ADP
bptjm-33	379	9	reducing	reduce	VERB
bptjm-33	379	10	tau	tau	PROPN
bptjm-33	379	11	phosphorylation	phosphorylation	NOUN
bptjm-33	379	12	and	and	CCONJ
bptjm-33	379	13	apoptosis	apoptosis	NOUN
bptjm-33	379	14	via	via	ADP
bptjm-33	379	15	gsk-3β	gsk-3β	ADJ
bptjm-33	379	16	signaling	signal	VERB
bptjm-33	379	17	pathways	pathway	NOUN
bptjm-33	379	18	.	.	PUNCT
bptjm-33	380	1	mol	mol	ADP
bptjm-33	380	2	ther	ther	ADV
bptjm-33	380	3	nucleic	nucleic	ADJ
bptjm-33	380	4	acids	acid	NOUN
bptjm-33	380	5	.	.	PUNCT
bptjm-33	381	1	2022;28:539	2022;28:539	NOUN
bptjm-33	381	2	-	-	SYM
bptjm-33	381	3	557	557	NUM
bptjm-33	381	4	.	.	PUNCT
bptjm-33	382	1	published	publish	VERB
bptjm-33	382	2	2022	2022	NUM
bptjm-33	382	3	apr	apr	PROPN
bptjm-33	382	4	18	18	NUM
bptjm-33	382	5	.	.	PUNCT
bptjm-33	382	6	doi:10.1016	doi:10.1016	PROPN
bptjm-33	382	7	/	/	SYM
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bptjm-33	383	8	l.	l.	NOUN
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bptjm-33	383	11	the	the	DET
bptjm-33	383	12	regulation	regulation	NOUN
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bptjm-33	383	16	.	.	PUNCT
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bptjm-33	384	6	disease	disease	NOUN
bptjm-33	384	7	.	.	PUNCT
bptjm-33	385	1	https://www.hindawi.com/journals/ijad/2012/4	https://www.hindawi.com/journals/ijad/2012/4	PROPN
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bptjm-33	385	8	.	.	PUNCT
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bptjm-33	386	4	,	,	PUNCT
bptjm-33	386	5	2022	2022	NUM
bptjm-33	386	6	.	.	PUNCT
bptjm-33	387	1	32	32	NUM
bptjm-33	387	2	.	.	PUNCT
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bptjm-33	389	10	translation	translation	PROPN
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bptjm-33	389	17	type	type	NOUN
bptjm-33	389	18	and	and	CCONJ
bptjm-33	389	19	3′-utr	3′-utr	NUM
bptjm-33	389	20	variation	variation	NOUN
bptjm-33	389	21	.	.	PUNCT
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bptjm-33	390	2	rep	rep	PROPN
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bptjm-33	390	4	2022;12(3074	2022;12(3074	NUM
bptjm-33	390	5	)	)	PUNCT
bptjm-33	390	6	.	.	PUNCT
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bptjm-33	391	2	33	33	NUM
bptjm-33	391	3	.	.	PUNCT
bptjm-33	392	1	cao	cao	PROPN
bptjm-33	392	2	j	j	PROPN
bptjm-33	392	3	,	,	PUNCT
bptjm-33	392	4	huang	huang	PROPN
bptjm-33	392	5	m	m	PROPN
bptjm-33	392	6	,	,	PUNCT
bptjm-33	392	7	guo	guo	PROPN
bptjm-33	392	8	l.	l.	PROPN
bptjm-33	392	9	,	,	PUNCT
bptjm-33	392	10	et	et	PROPN
bptjm-33	392	11	al	al	PROPN
bptjm-33	392	12	.	.	PROPN
bptjm-33	392	13	microrna-195	microrna-195	PROPN
bptjm-33	392	14	rescues	rescue	NOUN
bptjm-33	392	15	apoe4	apoe4	PROPN
bptjm-33	392	16	-	-	PUNCT
bptjm-33	392	17	induced	induced	ADJ
bptjm-33	392	18	cognitive	cognitive	ADJ
bptjm-33	392	19	de	de	PROPN
bptjm-33	392	20	�	�	PROPN
bptjm-33	392	21	cits	cit	NOUN
bptjm-33	392	22	and	and	CCONJ
bptjm-33	392	23	lysosomal	lysosomal	ADJ
bptjm-33	392	24	defects	defect	NOUN
bptjm-33	392	25	in	in	ADP
bptjm-33	392	26	alzheimer	alzheimer	PROPN
bptjm-33	392	27	’s	’s	PART
bptjm-33	392	28	disease	disease	NOUN
bptjm-33	392	29	pathogenesis	pathogenesis	NOUN
bptjm-33	392	30	.	.	PUNCT
bptjm-33	393	1	mol	mol	ADP
bptjm-33	393	2	psychiatry	psychiatry	NOUN
bptjm-33	393	3	.	.	PUNCT
bptjm-33	394	1	(	(	PUNCT
bptjm-33	394	2	2021	2021	NUM
bptjm-33	394	3	)	)	PUNCT
bptjm-33	394	4	;	;	PUNCT
bptjm-33	395	1	26:4687–4701	26:4687–4701	NUM
bptjm-33	395	2	.	.	PUNCT
bptjm-33	396	1	https://doi.org/10.1038/s41380-020-0824-3	https://doi.org/10.1038/s41380-020-0824-3	PROPN
bptjm-33	396	2	34	34	NUM
bptjm-33	396	3	.	.	PUNCT
bptjm-33	397	1	weller	weller	PROPN
bptjm-33	397	2	j	j	PROPN
bptjm-33	397	3	,	,	PUNCT
bptjm-33	397	4	budson	budson	PROPN
bptjm-33	397	5	a.	a.	PROPN
bptjm-33	397	6	current	current	PROPN
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bptjm-33	397	8	of	of	ADP
bptjm-33	397	9	alzheimer	alzheimer	PROPN
bptjm-33	397	10	's	's	PART
bptjm-33	397	11	disease	disease	NOUN
bptjm-33	397	12	diagnosis	diagnosis	NOUN
bptjm-33	397	13	and	and	CCONJ
bptjm-33	397	14	treatment	treatment	NOUN
bptjm-33	397	15	.	.	PUNCT
bptjm-33	398	1	f1000res	f1000re	NOUN
bptjm-33	398	2	.	.	PUNCT
bptjm-33	399	1	2018;7	2018;7	NUM
bptjm-33	399	2	:	:	PUNCT
bptjm-33	399	3	f1000	f1000	PROPN
bptjm-33	399	4	faculty	faculty	NOUN
bptjm-33	399	5	rev-1161	rev-1161	NOUN
bptjm-33	399	6	.	.	PUNCT
bptjm-33	400	1	published	publish	VERB
bptjm-33	400	2	2018	2018	NUM
bptjm-33	400	3	jul	jul	PROPN
bptjm-33	400	4	31	31	NUM
bptjm-33	400	5	.	.	PUNCT
bptjm-33	401	1	doi:10.12688	doi:10.12688	PROPN
bptjm-33	401	2	/	/	SYM
bptjm-33	401	3	f1000research.14506.1	f1000research.14506.1	PROPN
bptjm-33	401	4	35	35	NUM
bptjm-33	401	5	.	.	PUNCT
bptjm-33	402	1	guo	guo	PROPN
bptjm-33	402	2	r	r	PROPN
bptjm-33	402	3	,	,	PUNCT
bptjm-33	402	4	fan	fan	NOUN
bptjm-33	402	5	g	g	NOUN
bptjm-33	402	6	,	,	PUNCT
bptjm-33	402	7	zhang	zhang	PROPN
bptjm-33	402	8	j	j	PROPN
bptjm-33	402	9	,	,	PUNCT
bptjm-33	402	10	et	et	PROPN
bptjm-33	402	11	al	al	PROPN
bptjm-33	402	12	.	.	PUNCT
bptjm-33	403	1	a	a	DET
bptjm-33	403	2	9	9	NUM
bptjm-33	403	3	-	-	PUNCT
bptjm-33	403	4	microrna	microrna	PROPN
bptjm-33	403	5	berkeley	berkeley	PROPN
bptjm-33	403	6	pharma	pharma	PROPN
bptjm-33	403	7	tech	tech	PROPN
bptjm-33	403	8	journal	journal	NOUN
bptjm-33	403	9	of	of	ADP
bptjm-33	403	10	medicine	medicine	NOUN
bptjm-33	403	11	|	|	ADV
bptjm-33	403	12	68	68	NUM
bptjm-33	403	13	signature	signature	NOUN
bptjm-33	403	14	in	in	ADP
bptjm-33	403	15	serum	serum	NOUN
bptjm-33	403	16	serves	serve	VERB
bptjm-33	403	17	as	as	ADP
bptjm-33	403	18	a	a	DET
bptjm-33	403	19	noninvasive	noninvasive	ADJ
bptjm-33	403	20	biomarker	biomarker	NOUN
bptjm-33	403	21	in	in	ADP
bptjm-33	403	22	early	early	ADJ
bptjm-33	403	23	diagnosis	diagnosis	NOUN
bptjm-33	403	24	of	of	ADP
bptjm-33	403	25	alzheimer	alzheimer	PROPN
bptjm-33	403	26	's	's	PART
bptjm-33	403	27	disease	disease	NOUN
bptjm-33	403	28	.	.	PUNCT
bptjm-33	404	1	j	j	PROPN
bptjm-33	404	2	alzheimers	alzheimers	PROPN
bptjm-33	404	3	dis	dis	PROPN
bptjm-33	404	4	.	.	PUNCT
bptjm-33	405	1	2017;60(4):1365	2017;60(4):1365	PROPN
bptjm-33	405	2	-	-	PUNCT
bptjm-33	405	3	1377	1377	NUM
bptjm-33	405	4	.	.	PUNCT
bptjm-33	406	1	doi:10.3233	doi:10.3233	NOUN
bptjm-33	406	2	/	/	SYM
bptjm-33	406	3	jad-170343	jad-170343	NOUN
bptjm-33	406	4	36	36	NUM
bptjm-33	406	5	.	.	PUNCT
bptjm-33	407	1	fu	fu	PROPN
bptjm-33	407	2	y	y	PROPN
bptjm-33	407	3	,	,	PUNCT
bptjm-33	407	4	hu	hu	PROPN
bptjm-33	408	1	x	x	PROPN
bptjm-33	408	2	,	,	PUNCT
bptjm-33	408	3	zheng	zheng	PROPN
bptjm-33	408	4	c	c	PROPN
bptjm-33	408	5	,	,	PUNCT
bptjm-33	408	6	et	et	PROPN
bptjm-33	408	7	al	al	PROPN
bptjm-33	408	8	.	.	PROPN
bptjm-33	409	1	intrahippocampal	intrahippocampal	PROPN
bptjm-33	409	2	mir-342	mir-342	PROPN
bptjm-33	409	3	-	-	PUNCT
bptjm-33	409	4	3p	3p	NUM
bptjm-33	409	5	inhibition	inhibition	NOUN
bptjm-33	409	6	reduces	reduce	VERB
bptjm-33	409	7	β	β	NOUN
bptjm-33	409	8	-	-	ADJ
bptjm-33	409	9	amyloid	amyloid	ADJ
bptjm-33	409	10	plaques	plaque	NOUN
bptjm-33	409	11	and	and	CCONJ
bptjm-33	409	12	ameliorates	ameliorate	NOUN
bptjm-33	409	13	learning	learn	VERB
bptjm-33	409	14	and	and	CCONJ
bptjm-33	409	15	memory	memory	NOUN
bptjm-33	409	16	in	in	ADP
bptjm-33	409	17	alzheimer	alzheimer	PROPN
bptjm-33	409	18	's	's	PART
bptjm-33	409	19	disease	disease	NOUN
bptjm-33	409	20	.	.	PUNCT
bptjm-33	410	1	metab	metab	ADJ
bptjm-33	410	2	brain	brain	NOUN
bptjm-33	410	3	dis	dis	PROPN
bptjm-33	410	4	.	.	PUNCT
bptjm-33	411	1	2019;34(5):1355	2019;34(5):1355	NUM
bptjm-33	411	2	-	-	SYM
bptjm-33	411	3	1363	1363	NUM
bptjm-33	411	4	.	.	PUNCT
bptjm-33	412	1	doi:10.1007	doi:10.1007	VERB
bptjm-33	412	2	/	/	SYM
bptjm-33	412	3	s11011	s11011	NOUN
bptjm-33	412	4	-	-	PUNCT
bptjm-33	412	5	019	019	NUM
bptjm-33	412	6	-	-	PUNCT
bptjm-33	412	7	00438	00438	NUM
bptjm-33	412	8	-	-	SYM
bptjm-33	412	9	9	9	NUM
bptjm-33	412	10	37	37	NUM
bptjm-33	412	11	.	.	PUNCT
bptjm-33	413	1	yiannopoulou	yiannopoulou	PROPN
bptjm-33	413	2	kg	kg	PROPN
bptjm-33	413	3	,	,	PUNCT
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bptjm-33	413	5	sg	sg	PROPN
bptjm-33	413	6	.	.	PUNCT
bptjm-33	414	1	current	current	ADJ
bptjm-33	414	2	and	and	CCONJ
bptjm-33	414	3	future	future	ADJ
bptjm-33	414	4	treatments	treatment	NOUN
bptjm-33	414	5	in	in	ADP
bptjm-33	414	6	alzheimer	alzheimer	PROPN
bptjm-33	414	7	disease	disease	PROPN
bptjm-33	414	8	:	:	PUNCT
bptjm-33	414	9	an	an	DET
bptjm-33	414	10	update	update	NOUN
bptjm-33	414	11	.	.	PUNCT
bptjm-33	415	1	j	j	PROPN
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bptjm-33	415	3	nerv	nerv	PROPN
bptjm-33	415	4	syst	syst	PROPN
bptjm-33	415	5	dis	dis	PROPN
bptjm-33	415	6	.	.	PUNCT
bptjm-33	416	1	2020;12:1179573520907397	2020;12:1179573520907397	NUM
bptjm-33	416	2	.	.	PUNCT
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bptjm-33	416	4	2020	2020	NUM
bptjm-33	416	5	feb	feb	PROPN
bptjm-33	416	6	29	29	NUM
bptjm-33	416	7	.	.	PUNCT
bptjm-33	416	8	doi:10.1177/1179573520907397	doi:10.1177/1179573520907397	PROPN
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bptjm-33	416	10	.	.	PUNCT
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bptjm-33	417	2	methods	method	NOUN
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bptjm-33	417	4	using	use	VERB
bptjm-33	417	5	mirna	mirna	NOUN
bptjm-33	417	6	from	from	ADP
bptjm-33	417	7	bodily	bodily	PROPN
bptjm-33	417	8	�	�	PROPN
bptjm-33	417	9	uids	uids	PROPN
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bptjm-33	417	11	early	early	ADJ
bptjm-33	417	12	detection	detection	NOUN
bptjm-33	417	13	and	and	CCONJ
bptjm-33	417	14	monitoring	monitoring	NOUN
bptjm-33	417	15	of	of	ADP
bptjm-33	417	16	mild	mild	ADJ
bptjm-33	417	17	cognitive	cognitive	ADJ
bptjm-33	417	18	impairment	impairment	NOUN
bptjm-33	417	19	(	(	PUNCT
bptjm-33	417	20	mci	mci	NOUN
bptjm-33	417	21	)	)	PUNCT
bptjm-33	417	22	and	and	CCONJ
bptjm-33	417	23	alzheimer	alzheimer	PROPN
bptjm-33	417	24	's	's	PART
bptjm-33	417	25	disease	disease	NOUN
bptjm-33	417	26	(	(	PUNCT
bptjm-33	417	27	ad	ad	NOUN
bptjm-33	417	28	)	)	PUNCT
bptjm-33	417	29	.	.	PUNCT
bptjm-33	418	1	google	google	PROPN
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bptjm-33	418	3	.	.	PUNCT
bptjm-33	419	1	https://patents.google.com/patent/us102467	https://patents.google.com/patent/us102467	PUNCT
bptjm-33	419	2	47b2	47b2	NUM
bptjm-33	419	3	/	/	SYM
bptjm-33	419	4	en?q	en?q	PROPN
bptjm-33	420	1	=	=	ADJ
bptjm-33	420	2	mirna%2balzheimers&oq	mirna%2balzheimers&oq	ADJ
bptjm-33	420	3	=	=	NOUN
bptjm-33	420	4	mirna%2bfor%2balzheimers	mirna%2bfor%2balzheimer	NOUN
bptjm-33	420	5	.	.	PUNCT
bptjm-33	421	1	accessed	access	VERB
bptjm-33	421	2	october	october	PROPN
bptjm-33	421	3	3	3	NUM
bptjm-33	421	4	,	,	PUNCT
bptjm-33	421	5	2022	2022	NUM
bptjm-33	421	6	.	.	PUNCT
bptjm-33	422	1	39	39	NUM
bptjm-33	422	2	.	.	PUNCT
bptjm-33	423	1	cn103781919b9	cn103781919b9	NOUN
bptjm-33	423	2	indicate	indicate	VERB
bptjm-33	423	3	the	the	DET
bptjm-33	423	4	microrna	microrna	PROPN
bptjm-33	423	5	biomarker	biomarker	NOUN
bptjm-33	423	6	of	of	ADP
bptjm-33	423	7	alzheimer	alzheimer	PROPN
bptjm-33	423	8	's	's	PART
bptjm-33	423	9	.	.	PUNCT
bptjm-33	424	1	google	google	PROPN
bptjm-33	424	2	patents	patent	NOUN
bptjm-33	424	3	.	.	PUNCT
bptjm-33	425	1	https://patents.google.com/patent/cn1037	https://patents.google.com/patent/cn1037	X
bptjm-33	425	2	81919b9	81919b9	PROPN
bptjm-33	425	3	/	/	SYM
bptjm-33	425	4	en?q	en?q	PROPN
bptjm-33	425	5	=	=	NOUN
bptjm-33	425	6	mirna%2balzheimers&oq	mirna%2balzheimers&oq	X
bptjm-33	425	7	=	=	SYM
bptjm-33	425	8	mirna%2bfor%2balzheimers	mirna%2bfor%2balzheimer	NOUN
bptjm-33	425	9	.	.	PUNCT
bptjm-33	426	1	accessed	access	VERB
bptjm-33	426	2	october	october	PROPN
bptjm-33	426	3	3	3	NUM
bptjm-33	426	4	,	,	PUNCT
bptjm-33	426	5	2022	2022	NUM
bptjm-33	426	6	.	.	PUNCT
bptjm-33	427	1	40	40	NUM
bptjm-33	427	2	.	.	PUNCT
bptjm-33	428	1	ma	ma	PROPN
bptjm-33	428	2	n	n	CCONJ
bptjm-33	428	3	,	,	PUNCT
bptjm-33	428	4	tie	tie	VERB
bptjm-33	428	5	c	c	PROPN
bptjm-33	428	6	,	,	PUNCT
bptjm-33	428	7	yu	yu	PROPN
bptjm-33	428	8	b	b	PROPN
bptjm-33	428	9	,	,	PUNCT
bptjm-33	428	10	zhang	zhang	PROPN
bptjm-33	428	11	w	w	PROPN
bptjm-33	428	12	,	,	PUNCT
bptjm-33	428	13	wan	wan	PROPN
bptjm-33	428	14	j.	j.	PROPN
bptjm-33	428	15	identifying	identify	VERB
bptjm-33	428	16	lncrna	lncrna	NOUN
bptjm-33	428	17	-	-	PUNCT
bptjm-33	428	18	mirna	mirna	NOUN
bptjm-33	428	19	-	-	PUNCT
bptjm-33	428	20	mrna	mrna	PROPN
bptjm-33	428	21	networks	network	NOUN
bptjm-33	428	22	to	to	PART
bptjm-33	428	23	investigate	investigate	VERB
bptjm-33	428	24	alzheimer	alzheimer	PROPN
bptjm-33	428	25	's	's	PART
bptjm-33	428	26	disease	disease	NOUN
bptjm-33	428	27	pathogenesis	pathogenesis	NOUN
bptjm-33	428	28	and	and	CCONJ
bptjm-33	428	29	therapy	therapy	NOUN
bptjm-33	428	30	strategy	strategy	NOUN
bptjm-33	428	31	.	.	PUNCT
bptjm-33	429	1	aging	age	VERB
bptjm-33	429	2	(	(	PUNCT
bptjm-33	429	3	albany	albany	PROPN
bptjm-33	429	4	ny	ny	PROPN
bptjm-33	429	5	)	)	PUNCT
bptjm-33	429	6	.	.	PUNCT
bptjm-33	430	1	2020;12(3):2897	2020;12(3):2897	PROPN
bptjm-33	430	2	-	-	PUNCT
bptjm-33	430	3	2920	2920	NUM
bptjm-33	430	4	.	.	PUNCT
bptjm-33	431	1	doi:10.18632	doi:10.18632	PROPN
bptjm-33	431	2	/	/	SYM
bptjm-33	431	3	aging.102785	aging.102785	PROPN
bptjm-33	431	4	41	41	NUM
bptjm-33	431	5	.	.	PUNCT
bptjm-33	431	6	walgrave	walgrave	NOUN
bptjm-33	431	7	,	,	PUNCT
bptjm-33	431	8	h.	h.	PROPN
bptjm-33	431	9	,	,	PUNCT
bptjm-33	431	10	zhou	zhou	PROPN
bptjm-33	431	11	,	,	PUNCT
bptjm-33	431	12	l.	l.	PROPN
bptjm-33	431	13	,	,	PUNCT
bptjm-33	431	14	de	de	X
bptjm-33	431	15	strooper	strooper	PROPN
bptjm-33	431	16	,	,	PUNCT
bptjm-33	431	17	b.	b.	PROPN
bptjm-33	431	18	et	et	PROPN
bptjm-33	431	19	al	al	PROPN
bptjm-33	431	20	.	.	PUNCT
bptjm-33	432	1	the	the	DET
bptjm-33	432	2	promise	promise	NOUN
bptjm-33	432	3	of	of	ADP
bptjm-33	432	4	microrna	microrna	PROPN
bptjm-33	432	5	-	-	PUNCT
bptjm-33	432	6	based	base	VERB
bptjm-33	432	7	therapies	therapy	NOUN
bptjm-33	432	8	in	in	ADP
bptjm-33	432	9	alzheimer	alzheimer	PROPN
bptjm-33	432	10	’s	’s	PART
bptjm-33	432	11	disease	disease	NOUN
bptjm-33	432	12	:	:	PUNCT
bptjm-33	432	13	challenges	challenge	NOUN
bptjm-33	432	14	and	and	CCONJ
bptjm-33	432	15	perspectives	perspective	NOUN
bptjm-33	432	16	.	.	PUNCT
bptjm-33	433	1	mol	mol	ADP
bptjm-33	433	2	neurodegeneration	neurodegeneration	NOUN
bptjm-33	433	3	.	.	PUNCT
bptjm-33	433	4	2021	2021	NUM
bptjm-33	433	5	;	;	PUNCT
bptjm-33	433	6	16(76	16(76	NUM
bptjm-33	433	7	)	)	PUNCT
bptjm-33	433	8	.	.	PUNCT
bptjm-33	434	1	https://doi.org/10.1186/s13024-021-00496-7	https://doi.org/10.1186/s13024-021-00496-7	PROPN
bptjm-33	434	2	berkeley	berkeley	PROPN
bptjm-33	434	3	pharma	pharma	PROPN
bptjm-33	434	4	tech	tech	NOUN
bptjm-33	434	5	journal	journal	NOUN
bptjm-33	434	6	of	of	ADP
bptjm-33	434	7	medicine	medicine	NOUN
bptjm-33	434	8	|	|	ADV
bptjm-33	434	9	69	69	NUM
bptjm-33	434	10	front	front	ADJ
bptjm-33	434	11	page	page	NOUN
bptjm-33	434	12	ugorji	ugorji	VERB
bptjm-33	434	13	et	et	PROPN
bptjm-33	434	14	al	al	PROPN
bptjm-33	434	15	.	.	PROPN
bptjm-33	435	1	body	body	NOUN
bptjm-33	435	2	template_ugorji	template_ugorji	PROPN
bptjm-33	435	3	et	et	PROPN
bptjm-33	435	4	al	al	PROPN
bptjm-33	435	5	.	.	PUNCT
bptjm-33	436	1	references_ugorji	references_ugorji	PROPN
bptjm-33	436	2	et	et	PROPN
bptjm-33	436	3	al	al	PROPN
bptjm-33	436	4	.	.	PUNCT