id	sid	tid	token	lemma	pos
bptjm-38	1	1	berkeley	berkeley	PROPN
bptjm-38	1	2	pharma	pharma	PROPN
bptjm-38	1	3	tech	tech	NOUN
bptjm-38	1	4	journal	journal	NOUN
bptjm-38	1	5	of	of	ADP
bptjm-38	1	6	medicine	medicine	NOUN
bptjm-38	1	7	correspondence	correspondence	NOUN
bptjm-38	1	8	:	:	PUNCT
bptjm-38	2	1	kellyyan@berkeley.edu	kellyyan@berkeley.edu	PROPN
bptjm-38	2	2	keywords	keyword	NOUN
bptjm-38	2	3	:	:	PUNCT
bptjm-38	2	4	autism	autism	NOUN
bptjm-38	2	5	,	,	PUNCT
bptjm-38	2	6	gene	gene	NOUN
bptjm-38	2	7	therapy	therapy	NOUN
bptjm-38	2	8	,	,	PUNCT
bptjm-38	2	9	neurodevelopment	neurodevelopment	ADJ
bptjm-38	2	10	,	,	PUNCT
bptjm-38	2	11	genetic	genetic	ADJ
bptjm-38	2	12	factors	factor	NOUN
bptjm-38	2	13	,	,	PUNCT
bptjm-38	2	14	epigenetics	epigenetic	NOUN
bptjm-38	2	15	submitted	submit	VERB
bptjm-38	2	16	:	:	PUNCT
bptjm-38	2	17	december	december	PROPN
bptjm-38	2	18	11	11	NUM
bptjm-38	2	19	,	,	PUNCT
bptjm-38	2	20	2022	2022	NUM
bptjm-38	2	21	accepted	accept	VERB
bptjm-38	2	22	:	:	PUNCT
bptjm-38	2	23	january	january	PROPN
bptjm-38	2	24	27	27	NUM
bptjm-38	2	25	,	,	PUNCT
bptjm-38	2	26	2023	2023	NUM
bptjm-38	2	27	published	publish	VERB
bptjm-38	2	28	:	:	PUNCT
bptjm-38	2	29	june	june	PROPN
bptjm-38	2	30	30	30	NUM
bptjm-38	2	31	,	,	PUNCT
bptjm-38	2	32	2023	2023	NUM
bptjm-38	2	33	full	full	ADJ
bptjm-38	2	34	open	open	ADJ
bptjm-38	2	35	access	access	NOUN
bptjm-38	2	36	creative	creative	ADJ
bptjm-38	2	37	commons	common	NOUN
bptjm-38	2	38	attribution	attribution	NOUN
bptjm-38	2	39	license	license	VERB
bptjm-38	2	40	4.0	4.0	NUM
bptjm-38	2	41	abstract	abstract	ADJ
bptjm-38	2	42	autism	autism	NOUN
bptjm-38	2	43	spectrum	spectrum	NOUN
bptjm-38	2	44	disorder	disorder	NOUN
bptjm-38	2	45	(	(	PUNCT
bptjm-38	2	46	asd	asd	NOUN
bptjm-38	2	47	)	)	PUNCT
bptjm-38	2	48	is	be	AUX
bptjm-38	2	49	a	a	DET
bptjm-38	2	50	range	range	NOUN
bptjm-38	2	51	of	of	ADP
bptjm-38	2	52	developmental	developmental	ADJ
bptjm-38	2	53	disorders	disorder	NOUN
bptjm-38	2	54	characterized	characterize	VERB
bptjm-38	2	55	by	by	ADP
bptjm-38	2	56	impaired	impaired	ADJ
bptjm-38	2	57	traits	trait	NOUN
bptjm-38	2	58	associated	associate	VERB
bptjm-38	2	59	with	with	ADP
bptjm-38	2	60	three	three	NUM
bptjm-38	2	61	distinct	distinct	ADJ
bptjm-38	2	62	domains	domain	NOUN
bptjm-38	2	63	:	:	PUNCT
bptjm-38	2	64	communication	communication	NOUN
bptjm-38	2	65	,	,	PUNCT
bptjm-38	2	66	social	social	ADJ
bptjm-38	2	67	interaction	interaction	NOUN
bptjm-38	2	68	,	,	PUNCT
bptjm-38	2	69	and	and	CCONJ
bptjm-38	2	70	stereotypic	stereotypic	ADJ
bptjm-38	2	71	repetitive	repetitive	ADJ
bptjm-38	2	72	behavior	behavior	NOUN
bptjm-38	2	73	.	.	PUNCT
bptjm-38	3	1	although	although	SCONJ
bptjm-38	3	2	the	the	DET
bptjm-38	3	3	etiology	etiology	NOUN
bptjm-38	3	4	of	of	ADP
bptjm-38	3	5	asd	asd	PROPN
bptjm-38	3	6	depends	depend	VERB
bptjm-38	3	7	on	on	ADP
bptjm-38	3	8	various	various	ADJ
bptjm-38	3	9	components	component	NOUN
bptjm-38	3	10	,	,	PUNCT
bptjm-38	3	11	current	current	ADJ
bptjm-38	3	12	research	research	NOUN
bptjm-38	3	13	mainly	mainly	ADV
bptjm-38	3	14	focuses	focus	VERB
bptjm-38	3	15	on	on	ADP
bptjm-38	3	16	the	the	DET
bptjm-38	3	17	genetic	genetic	ADJ
bptjm-38	3	18	factors	factor	NOUN
bptjm-38	3	19	that	that	PRON
bptjm-38	3	20	contribute	contribute	VERB
bptjm-38	3	21	to	to	ADP
bptjm-38	3	22	the	the	DET
bptjm-38	3	23	development	development	NOUN
bptjm-38	3	24	of	of	ADP
bptjm-38	3	25	asd	asd	NOUN
bptjm-38	3	26	and	and	CCONJ
bptjm-38	3	27	its	its	PRON
bptjm-38	3	28	effects	effect	NOUN
bptjm-38	3	29	.	.	PUNCT
bptjm-38	4	1	a	a	DET
bptjm-38	4	2	big	big	ADJ
bptjm-38	4	3	treatment	treatment	NOUN
bptjm-38	4	4	consideration	consideration	NOUN
bptjm-38	4	5	is	be	AUX
bptjm-38	4	6	gene	gene	NOUN
bptjm-38	4	7	therapy	therapy	NOUN
bptjm-38	4	8	,	,	PUNCT
bptjm-38	4	9	which	which	PRON
bptjm-38	4	10	has	have	VERB
bptjm-38	4	11	disease	disease	NOUN
bptjm-38	4	12	-	-	PUNCT
bptjm-38	4	13	modifying	modify	VERB
bptjm-38	4	14	potential	potential	NOUN
bptjm-38	4	15	.	.	PUNCT
bptjm-38	5	1	this	this	DET
bptjm-38	5	2	article	article	NOUN
bptjm-38	5	3	provides	provide	VERB
bptjm-38	5	4	insight	insight	NOUN
bptjm-38	5	5	into	into	ADP
bptjm-38	5	6	the	the	DET
bptjm-38	5	7	foundation	foundation	NOUN
bptjm-38	5	8	of	of	ADP
bptjm-38	5	9	asd	asd	PROPN
bptjm-38	5	10	and	and	CCONJ
bptjm-38	5	11	the	the	DET
bptjm-38	5	12	leading	lead	VERB
bptjm-38	5	13	gene	gene	NOUN
bptjm-38	5	14	therapies	therapy	NOUN
bptjm-38	5	15	that	that	PRON
bptjm-38	5	16	aim	aim	VERB
bptjm-38	5	17	to	to	PART
bptjm-38	5	18	address	address	VERB
bptjm-38	5	19	impaired	impaired	ADJ
bptjm-38	5	20	neurological	neurological	ADJ
bptjm-38	5	21	behavior	behavior	NOUN
bptjm-38	5	22	.	.	PUNCT
bptjm-38	6	1	we	we	PRON
bptjm-38	6	2	will	will	AUX
bptjm-38	6	3	discuss	discuss	VERB
bptjm-38	6	4	how	how	SCONJ
bptjm-38	6	5	certain	certain	ADJ
bptjm-38	6	6	genetic	genetic	ADJ
bptjm-38	6	7	factors	factor	NOUN
bptjm-38	6	8	can	can	AUX
bptjm-38	6	9	have	have	VERB
bptjm-38	6	10	large	large	ADJ
bptjm-38	6	11	contributions	contribution	NOUN
bptjm-38	6	12	to	to	ADP
bptjm-38	6	13	asd	asd	PROPN
bptjm-38	6	14	development	development	NOUN
bptjm-38	6	15	and	and	CCONJ
bptjm-38	6	16	how	how	SCONJ
bptjm-38	6	17	scientists	scientist	NOUN
bptjm-38	6	18	can	can	AUX
bptjm-38	6	19	go	go	VERB
bptjm-38	6	20	about	about	ADP
bptjm-38	6	21	targeting	target	VERB
bptjm-38	6	22	these	these	DET
bptjm-38	6	23	factors	factor	NOUN
bptjm-38	6	24	for	for	ADP
bptjm-38	6	25	potential	potential	ADJ
bptjm-38	6	26	remedies	remedy	NOUN
bptjm-38	6	27	.	.	PUNCT
bptjm-38	7	1	gene	gene	NOUN
bptjm-38	7	2	therapy	therapy	NOUN
bptjm-38	7	3	as	as	ADP
bptjm-38	7	4	a	a	DET
bptjm-38	7	5	promising	promising	ADJ
bptjm-38	7	6	approach	approach	NOUN
bptjm-38	7	7	for	for	ADP
bptjm-38	7	8	the	the	DET
bptjm-38	7	9	underlying	underlie	VERB
bptjm-38	7	10	causes	cause	NOUN
bptjm-38	7	11	of	of	ADP
bptjm-38	7	12	autism	autism	NOUN
bptjm-38	7	13	spectrum	spectrum	NOUN
bptjm-38	7	14	disorder	disorder	NOUN
bptjm-38	7	15	by	by	ADP
bptjm-38	7	16	:	:	PUNCT
bptjm-38	7	17	kelly	kelly	PROPN
bptjm-38	7	18	an	an	PROPN
bptjm-38	7	19	,	,	PUNCT
bptjm-38	7	20	fadel	fadel	PROPN
bptjm-38	7	21	batal	batal	PROPN
bptjm-38	7	22	,	,	PUNCT
bptjm-38	7	23	sonya	sonya	PROPN
bptjm-38	7	24	svyatskya	svyatskya	PROPN
bptjm-38	7	25	,	,	PUNCT
bptjm-38	7	26	vanloan	vanloan	PROPN
bptjm-38	7	27	nguyen	nguyen	PROPN
bptjm-38	7	28	autismspectrumdisorder	autismspectrumdisorder	PROPN
bptjm-38	7	29	introduction	introduction	NOUN
bptjm-38	7	30	autism	autism	NOUN
bptjm-38	7	31	spectrum	spectrum	NOUN
bptjm-38	7	32	disorder	disorder	NOUN
bptjm-38	7	33	(	(	PUNCT
bptjm-38	7	34	asd	asd	NOUN
bptjm-38	7	35	)	)	PUNCT
bptjm-38	7	36	is	be	AUX
bptjm-38	7	37	a	a	DET
bptjm-38	7	38	neurodevelopmental	neurodevelopmental	ADJ
bptjm-38	7	39	condition	condition	NOUN
bptjm-38	7	40	that	that	SCONJ
bptjm-38	7	41	a	a	DET
bptjm-38	7	42	�	�	NOUN
bptjm-38	7	43	ects	ect	VERB
bptjm-38	7	44	communication	communication	NOUN
bptjm-38	7	45	and	and	CCONJ
bptjm-38	7	46	social	social	ADJ
bptjm-38	7	47	interaction	interaction	NOUN
bptjm-38	7	48	.	.	PUNCT
bptjm-38	8	1	it	it	PRON
bptjm-38	8	2	is	be	AUX
bptjm-38	8	3	a	a	DET
bptjm-38	8	4	complex	complex	ADJ
bptjm-38	8	5	condition	condition	NOUN
bptjm-38	8	6	with	with	ADP
bptjm-38	8	7	a	a	DET
bptjm-38	8	8	range	range	NOUN
bptjm-38	8	9	of	of	ADP
bptjm-38	8	10	symptoms	symptom	NOUN
bptjm-38	8	11	and	and	CCONJ
bptjm-38	8	12	severity	severity	NOUN
bptjm-38	8	13	levels	level	NOUN
bptjm-38	8	14	,	,	PUNCT
bptjm-38	8	15	and	and	CCONJ
bptjm-38	8	16	the	the	DET
bptjm-38	8	17	exact	exact	ADJ
bptjm-38	8	18	causes	cause	NOUN
bptjm-38	8	19	are	be	AUX
bptjm-38	8	20	still	still	ADV
bptjm-38	8	21	not	not	PART
bptjm-38	8	22	fully	fully	ADV
bptjm-38	8	23	understood	understand	VERB
bptjm-38	8	24	.	.	PUNCT
bptjm-38	9	1	1	1	NUM
bptjm-38	9	2	however	however	ADV
bptjm-38	9	3	,	,	PUNCT
bptjm-38	9	4	genetic	genetic	ADJ
bptjm-38	9	5	factors	factor	NOUN
bptjm-38	9	6	are	be	AUX
bptjm-38	9	7	believed	believe	VERB
bptjm-38	9	8	to	to	PART
bptjm-38	9	9	play	play	VERB
bptjm-38	9	10	a	a	DET
bptjm-38	9	11	signi	signi	ADJ
bptjm-38	9	12	�	�	NOUN
bptjm-38	9	13	cant	cant	NOUN
bptjm-38	9	14	role	role	NOUN
bptjm-38	9	15	in	in	ADP
bptjm-38	9	16	the	the	DET
bptjm-38	9	17	development	development	NOUN
bptjm-38	9	18	of	of	ADP
bptjm-38	9	19	asd	asd	PROPN
bptjm-38	9	20	.	.	PROPN
bptjm-38	9	21	2	2	NUM
bptjm-38	9	22	symptoms	symptom	NOUN
bptjm-38	9	23	of	of	ADP
bptjm-38	9	24	asd	asd	NOUN
bptjm-38	9	25	,	,	PUNCT
bptjm-38	9	26	which	which	PRON
bptjm-38	9	27	typically	typically	ADV
bptjm-38	9	28	appear	appear	VERB
bptjm-38	9	29	in	in	ADP
bptjm-38	9	30	early	early	ADJ
bptjm-38	9	31	childhood	childhood	NOUN
bptjm-38	9	32	,	,	PUNCT
bptjm-38	9	33	include	include	VERB
bptjm-38	9	34	impaired	impaired	ADJ
bptjm-38	9	35	social	social	ADJ
bptjm-38	9	36	interaction	interaction	NOUN
bptjm-38	9	37	and	and	CCONJ
bptjm-38	9	38	communication	communication	NOUN
bptjm-38	9	39	,	,	PUNCT
bptjm-38	9	40	repetitive	repetitive	ADJ
bptjm-38	9	41	behaviors	behavior	NOUN
bptjm-38	9	42	and	and	CCONJ
bptjm-38	9	43	interests	interest	NOUN
bptjm-38	9	44	,	,	PUNCT
bptjm-38	9	45	and	and	CCONJ
bptjm-38	9	46	sensory	sensory	ADJ
bptjm-38	9	47	processing	processing	NOUN
bptjm-38	9	48	issues	issue	NOUN
bptjm-38	9	49	.	.	PUNCT
bptjm-38	10	1	these	these	DET
bptjm-38	10	2	symptoms	symptom	NOUN
bptjm-38	10	3	range	range	VERB
bptjm-38	10	4	from	from	ADP
bptjm-38	10	5	mild	mild	ADJ
bptjm-38	10	6	to	to	ADP
bptjm-38	10	7	severe	severe	ADJ
bptjm-38	10	8	and	and	CCONJ
bptjm-38	10	9	may	may	AUX
bptjm-38	10	10	a	a	DET
bptjm-38	10	11	�	�	VERB
bptjm-38	10	12	ect	ect	VERB
bptjm-38	10	13	an	an	DET
bptjm-38	10	14	individual	individual	NOUN
bptjm-38	10	15	's	's	PART
bptjm-38	10	16	ability	ability	NOUN
bptjm-38	10	17	to	to	PART
bptjm-38	10	18	function	function	VERB
bptjm-38	10	19	in	in	ADP
bptjm-38	10	20	daily	daily	ADJ
bptjm-38	10	21	life	life	NOUN
bptjm-38	10	22	.	.	PUNCT
bptjm-38	11	1	1	1	NUM
bptjm-38	11	2	,	,	PUNCT
bptjm-38	11	3	3	3	NUM
bptjm-38	11	4	at	at	ADP
bptjm-38	11	5	a	a	DET
bptjm-38	11	6	brain	brain	NOUN
bptjm-38	11	7	developmental	developmental	ADJ
bptjm-38	11	8	level	level	NOUN
bptjm-38	11	9	,	,	PUNCT
bptjm-38	11	10	asd	asd	PROPN
bptjm-38	11	11	is	be	AUX
bptjm-38	11	12	thought	think	VERB
bptjm-38	11	13	to	to	PART
bptjm-38	11	14	result	result	VERB
bptjm-38	11	15	from	from	ADP
bptjm-38	11	16	abnormal	abnormal	ADJ
bptjm-38	11	17	development	development	NOUN
bptjm-38	11	18	,	,	PUNCT
bptjm-38	11	19	particularly	particularly	ADV
bptjm-38	11	20	in	in	ADP
bptjm-38	11	21	regions	region	NOUN
bptjm-38	11	22	of	of	ADP
bptjm-38	11	23	the	the	DET
bptjm-38	11	24	brain	brain	NOUN
bptjm-38	11	25	involved	involve	VERB
bptjm-38	11	26	in	in	ADP
bptjm-38	11	27	social	social	ADJ
bptjm-38	11	28	interaction	interaction	NOUN
bptjm-38	11	29	and	and	CCONJ
bptjm-38	11	30	communication	communication	NOUN
bptjm-38	11	31	.	.	PUNCT
bptjm-38	12	1	some	some	DET
bptjm-38	12	2	studies	study	NOUN
bptjm-38	12	3	have	have	AUX
bptjm-38	12	4	suggested	suggest	VERB
bptjm-38	12	5	that	that	SCONJ
bptjm-38	12	6	individuals	individual	NOUN
bptjm-38	12	7	with	with	ADP
bptjm-38	12	8	asd	asd	PROPN
bptjm-38	12	9	may	may	AUX
bptjm-38	12	10	have	have	VERB
bptjm-38	12	11	di	di	NOUN
bptjm-38	12	12	�	�	NOUN
bptjm-38	12	13	erences	erence	NOUN
bptjm-38	12	14	in	in	ADP
bptjm-38	12	15	brain	brain	NOUN
bptjm-38	12	16	structure	structure	NOUN
bptjm-38	12	17	and	and	CCONJ
bptjm-38	12	18	function	function	NOUN
bptjm-38	12	19	,	,	PUNCT
bptjm-38	12	20	such	such	ADJ
bptjm-38	12	21	as	as	ADP
bptjm-38	12	22	altered	alter	VERB
bptjm-38	12	23	connectivity	connectivity	NOUN
bptjm-38	12	24	between	between	ADP
bptjm-38	12	25	di	di	NOUN
bptjm-38	12	26	�	�	PROPN
bptjm-38	12	27	erent	erent	NOUN
bptjm-38	12	28	regions	region	NOUN
bptjm-38	12	29	.	.	PUNCT
bptjm-38	13	1	4	4	NUM
bptjm-38	13	2	at	at	ADP
bptjm-38	13	3	a	a	DET
bptjm-38	13	4	genetic	genetic	ADJ
bptjm-38	13	5	level	level	NOUN
bptjm-38	13	6	,	,	PUNCT
bptjm-38	13	7	asd	asd	PROPN
bptjm-38	13	8	is	be	AUX
bptjm-38	13	9	believed	believe	VERB
bptjm-38	13	10	to	to	PART
bptjm-38	13	11	be	be	AUX
bptjm-38	13	12	caused	cause	VERB
bptjm-38	13	13	by	by	ADP
bptjm-38	13	14	a	a	DET
bptjm-38	13	15	combination	combination	NOUN
bptjm-38	13	16	of	of	ADP
bptjm-38	13	17	genetic	genetic	ADJ
bptjm-38	13	18	and	and	CCONJ
bptjm-38	13	19	environmental	environmental	ADJ
bptjm-38	13	20	factors	factor	NOUN
bptjm-38	13	21	.	.	PUNCT
bptjm-38	14	1	while	while	SCONJ
bptjm-38	14	2	the	the	DET
bptjm-38	14	3	exact	exact	ADJ
bptjm-38	14	4	causes	cause	NOUN
bptjm-38	14	5	of	of	ADP
bptjm-38	14	6	asd	asd	NOUN
bptjm-38	14	7	are	be	AUX
bptjm-38	14	8	still	still	ADV
bptjm-38	14	9	not	not	PART
bptjm-38	14	10	fully	fully	ADV
bptjm-38	14	11	understood	understand	VERB
bptjm-38	14	12	,	,	PUNCT
bptjm-38	14	13	research	research	NOUN
bptjm-38	14	14	has	have	VERB
bptjm-38	14	15	identi	identi	NOUN
bptjm-38	14	16	�	�	NOUN
bptjm-38	14	17	ed	ed	NOUN
bptjm-38	14	18	a	a	DET
bptjm-38	14	19	number	number	NOUN
bptjm-38	14	20	of	of	ADP
bptjm-38	14	21	genetic	genetic	ADJ
bptjm-38	14	22	variations	variation	NOUN
bptjm-38	14	23	that	that	PRON
bptjm-38	14	24	are	be	AUX
bptjm-38	14	25	associated	associate	VERB
bptjm-38	14	26	with	with	ADP
bptjm-38	14	27	an	an	DET
bptjm-38	14	28	increased	increase	VERB
bptjm-38	14	29	risk	risk	NOUN
bptjm-38	14	30	of	of	ADP
bptjm-38	14	31	developing	develop	VERB
bptjm-38	14	32	the	the	DET
bptjm-38	14	33	condition	condition	NOUN
bptjm-38	14	34	.	.	PUNCT
bptjm-38	15	1	these	these	DET
bptjm-38	15	2	genetic	genetic	ADJ
bptjm-38	15	3	factors	factor	NOUN
bptjm-38	15	4	may	may	AUX
bptjm-38	15	5	interact	interact	VERB
bptjm-38	15	6	with	with	ADP
bptjm-38	15	7	environmental	environmental	ADJ
bptjm-38	15	8	factors	factor	NOUN
bptjm-38	15	9	to	to	ADP
bptjm-38	15	10	in	in	ADP
bptjm-38	15	11	�	�	NOUN
bptjm-38	15	12	uence	uence	NOUN
bptjm-38	15	13	brain	brain	NOUN
bptjm-38	15	14	development	development	NOUN
bptjm-38	15	15	,	,	PUNCT
bptjm-38	15	16	ultimately	ultimately	ADV
bptjm-38	15	17	resulting	result	VERB
bptjm-38	15	18	in	in	ADP
bptjm-38	15	19	asd	asd	PROPN
bptjm-38	15	20	.	.	PROPN
bptjm-38	15	21	1	1	NUM
bptjm-38	15	22	autism	autism	NOUN
bptjm-38	15	23	is	be	AUX
bptjm-38	15	24	one	one	NUM
bptjm-38	15	25	of	of	ADP
bptjm-38	15	26	the	the	DET
bptjm-38	15	27	most	most	ADV
bptjm-38	15	28	heritable	heritable	ADJ
bptjm-38	15	29	neurodevelopmental	neurodevelopmental	ADJ
bptjm-38	15	30	disorders	disorder	NOUN
bptjm-38	15	31	,	,	PUNCT
bptjm-38	15	32	a	a	DET
bptjm-38	15	33	�	�	NOUN
bptjm-38	15	34	ecting	ecte	VERB
bptjm-38	15	35	78	78	NUM
bptjm-38	15	36	million	million	NUM
bptjm-38	15	37	people	people	NOUN
bptjm-38	15	38	or	or	CCONJ
bptjm-38	15	39	1.5	1.5	NUM
bptjm-38	15	40	%	%	NOUN
bptjm-38	15	41	of	of	ADP
bptjm-38	15	42	the	the	DET
bptjm-38	15	43	world	world	NOUN
bptjm-38	15	44	’s	’s	PART
bptjm-38	15	45	population	population	NOUN
bptjm-38	15	46	.	.	PUNCT
bptjm-38	16	1	5	5	NUM
bptjm-38	16	2	despite	despite	SCONJ
bptjm-38	16	3	its	its	PRON
bptjm-38	16	4	ubiquitous	ubiquitous	ADJ
bptjm-38	16	5	existence	existence	NOUN
bptjm-38	16	6	,	,	PUNCT
bptjm-38	16	7	there	there	PRON
bptjm-38	16	8	are	be	VERB
bptjm-38	16	9	aspects	aspect	NOUN
bptjm-38	16	10	of	of	ADP
bptjm-38	16	11	the	the	DET
bptjm-38	16	12	disorder	disorder	NOUN
bptjm-38	16	13	that	that	PRON
bptjm-38	16	14	science	science	NOUN
bptjm-38	16	15	has	have	VERB
bptjm-38	16	16	yet	yet	ADV
bptjm-38	16	17	to	to	PART
bptjm-38	16	18	unveil	unveil	VERB
bptjm-38	16	19	.	.	PUNCT
bptjm-38	17	1	with	with	ADP
bptjm-38	17	2	the	the	DET
bptjm-38	17	3	etiology	etiology	NOUN
bptjm-38	17	4	of	of	ADP
bptjm-38	17	5	autism	autism	NOUN
bptjm-38	17	6	still	still	ADV
bptjm-38	17	7	in	in	ADP
bptjm-38	17	8	question	question	NOUN
bptjm-38	17	9	,	,	PUNCT
bptjm-38	17	10	scientists	scientist	NOUN
bptjm-38	17	11	have	have	AUX
bptjm-38	17	12	been	be	AUX
bptjm-38	17	13	able	able	ADJ
bptjm-38	17	14	to	to	PART
bptjm-38	17	15	conclude	conclude	VERB
bptjm-38	17	16	that	that	SCONJ
bptjm-38	17	17	at	at	ADV
bptjm-38	17	18	least	least	ADV
bptjm-38	17	19	40	40	NUM
bptjm-38	17	20	%	%	NOUN
bptjm-38	17	21	of	of	ADP
bptjm-38	17	22	neurobehavioral	neurobehavioral	ADJ
bptjm-38	17	23	disorders	disorder	NOUN
bptjm-38	17	24	within	within	ADP
bptjm-38	17	25	the	the	DET
bptjm-38	17	26	autism	autism	NOUN
bptjm-38	17	27	spectrum	spectrum	NOUN
bptjm-38	17	28	are	be	AUX
bptjm-38	17	29	the	the	DET
bptjm-38	17	30	result	result	NOUN
bptjm-38	17	31	of	of	ADP
bptjm-38	17	32	genetic	genetic	ADJ
bptjm-38	17	33	abnormalities	abnormality	NOUN
bptjm-38	17	34	.	.	PUNCT
bptjm-38	18	1	6	6	NUM
bptjm-38	18	2	the	the	DET
bptjm-38	18	3	current	current	ADJ
bptjm-38	18	4	treatment	treatment	NOUN
bptjm-38	18	5	for	for	ADP
bptjm-38	18	6	asd	asd	NOUN
bptjm-38	18	7	falls	fall	VERB
bptjm-38	18	8	into	into	ADP
bptjm-38	18	9	two	two	NUM
bptjm-38	18	10	categories	category	NOUN
bptjm-38	18	11	:	:	PUNCT
bptjm-38	18	12	those	those	PRON
bptjm-38	18	13	that	that	PRON
bptjm-38	18	14	target	target	VERB
bptjm-38	18	15	core	core	NOUN
bptjm-38	18	16	symptoms	symptom	NOUN
bptjm-38	18	17	which	which	PRON
bptjm-38	18	18	include	include	VERB
bptjm-38	18	19	impaired	impaired	ADJ
bptjm-38	18	20	communication	communication	NOUN
bptjm-38	18	21	,	,	PUNCT
bptjm-38	18	22	social	social	ADJ
bptjm-38	18	23	interaction	interaction	NOUN
bptjm-38	18	24	,	,	PUNCT
bptjm-38	18	25	and	and	CCONJ
bptjm-38	18	26	repetitive	repetitive	ADJ
bptjm-38	18	27	behaviors	behavior	NOUN
bptjm-38	18	28	;	;	PUNCT
bptjm-38	18	29	and	and	CCONJ
bptjm-38	18	30	those	those	PRON
bptjm-38	18	31	that	that	PRON
bptjm-38	18	32	target	target	VERB
bptjm-38	18	33	secondary	secondary	ADJ
bptjm-38	18	34	or	or	CCONJ
bptjm-38	18	35	consequential	consequential	ADJ
bptjm-38	18	36	symptoms	symptom	NOUN
bptjm-38	18	37	such	such	ADJ
bptjm-38	18	38	as	as	ADP
bptjm-38	18	39	adhd	adhd	NOUN
bptjm-38	18	40	and	and	CCONJ
bptjm-38	18	41	irritability	irritability	NOUN
bptjm-38	18	42	.	.	PUNCT
bptjm-38	19	1	gene	gene	NOUN
bptjm-38	19	2	therapy	therapy	NOUN
bptjm-38	19	3	,	,	PUNCT
bptjm-38	19	4	a	a	DET
bptjm-38	19	5	treatment	treatment	NOUN
bptjm-38	19	6	that	that	PRON
bptjm-38	19	7	targets	target	VERB
bptjm-38	19	8	core	core	NOUN
bptjm-38	19	9	symptoms	symptom	NOUN
bptjm-38	19	10	,	,	PUNCT
bptjm-38	19	11	focuses	focus	VERB
bptjm-38	19	12	on	on	ADP
bptjm-38	19	13	mending	mend	VERB
bptjm-38	19	14	genetic	genetic	ADJ
bptjm-38	19	15	building	building	NOUN
bptjm-38	19	16	blocks	block	NOUN
bptjm-38	19	17	.	.	PUNCT
bptjm-38	20	1	it	it	PRON
bptjm-38	20	2	aims	aim	VERB
bptjm-38	20	3	berkeley	berkeley	PROPN
bptjm-38	20	4	pharma	pharma	PROPN
bptjm-38	20	5	tech	tech	NOUN
bptjm-38	20	6	journal	journal	NOUN
bptjm-38	20	7	of	of	ADP
bptjm-38	20	8	medicine	medicine	NOUN
bptjm-38	20	9	|	|	ADV
bptjm-38	20	10	11	11	NUM
bptjm-38	20	11	to	to	PART
bptjm-38	20	12	alter	alter	VERB
bptjm-38	20	13	abnormalities	abnormality	NOUN
bptjm-38	20	14	in	in	ADP
bptjm-38	20	15	hopes	hope	NOUN
bptjm-38	20	16	of	of	ADP
bptjm-38	20	17	preventing	prevent	VERB
bptjm-38	20	18	domino	domino	NOUN
bptjm-38	20	19	-	-	PUNCT
bptjm-38	20	20	e	e	NOUN
bptjm-38	20	21	�	�	NOUN
bptjm-38	20	22	ects	ect	VERB
bptjm-38	20	23	in	in	ADP
bptjm-38	20	24	the	the	DET
bptjm-38	20	25	body	body	NOUN
bptjm-38	20	26	that	that	PRON
bptjm-38	20	27	result	result	VERB
bptjm-38	20	28	in	in	ADP
bptjm-38	20	29	the	the	DET
bptjm-38	20	30	neurobehavioral	neurobehavioral	ADJ
bptjm-38	20	31	de	de	PROPN
bptjm-38	20	32	�	�	PROPN
bptjm-38	20	33	cits	cit	NOUN
bptjm-38	20	34	which	which	PRON
bptjm-38	20	35	characterize	characterize	VERB
bptjm-38	20	36	asd	asd	NOUN
bptjm-38	20	37	.	.	PUNCT
bptjm-38	21	1	using	use	VERB
bptjm-38	21	2	viral	viral	ADJ
bptjm-38	21	3	vectors	vector	NOUN
bptjm-38	21	4	such	such	ADJ
bptjm-38	21	5	as	as	ADP
bptjm-38	21	6	recombinant	recombinant	ADJ
bptjm-38	21	7	adeno	adeno	NOUN
bptjm-38	21	8	-	-	PUNCT
bptjm-38	21	9	associated	associate	VERB
bptjm-38	21	10	viruses	virus	NOUN
bptjm-38	21	11	,	,	PUNCT
bptjm-38	21	12	gene	gene	NOUN
bptjm-38	21	13	therapy	therapy	NOUN
bptjm-38	21	14	is	be	AUX
bptjm-38	21	15	able	able	ADJ
bptjm-38	21	16	to	to	PART
bptjm-38	21	17	introduce	introduce	VERB
bptjm-38	21	18	new	new	ADJ
bptjm-38	21	19	genetic	genetic	ADJ
bptjm-38	21	20	material	material	NOUN
bptjm-38	21	21	to	to	PART
bptjm-38	21	22	counteract	counteract	VERB
bptjm-38	21	23	the	the	DET
bptjm-38	21	24	establishment	establishment	NOUN
bptjm-38	21	25	of	of	ADP
bptjm-38	21	26	asd	asd	NOUN
bptjm-38	21	27	symptoms	symptom	NOUN
bptjm-38	21	28	.	.	PUNCT
bptjm-38	22	1	7	7	NUM
bptjm-38	22	2	this	this	DET
bptjm-38	22	3	paper	paper	NOUN
bptjm-38	22	4	will	will	AUX
bptjm-38	22	5	be	be	AUX
bptjm-38	22	6	discussing	discuss	VERB
bptjm-38	22	7	studies	study	NOUN
bptjm-38	22	8	and	and	CCONJ
bptjm-38	22	9	their	their	PRON
bptjm-38	22	10	adaptation	adaptation	NOUN
bptjm-38	22	11	of	of	ADP
bptjm-38	22	12	gene	gene	NOUN
bptjm-38	22	13	therapy	therapy	NOUN
bptjm-38	22	14	to	to	ADP
bptjm-38	22	15	varying	vary	VERB
bptjm-38	22	16	pathophysiologies	pathophysiologie	NOUN
bptjm-38	22	17	of	of	ADP
bptjm-38	22	18	asd	asd	NOUN
bptjm-38	22	19	in	in	ADP
bptjm-38	22	20	order	order	NOUN
bptjm-38	22	21	to	to	AUX
bptjm-38	22	22	o	o	VERB
bptjm-38	22	23	�	�	PROPN
bptjm-38	22	24	er	er	PROPN
bptjm-38	22	25	e	e	NOUN
bptjm-38	22	26	�	�	PROPN
bptjm-38	22	27	ective	ective	ADJ
bptjm-38	22	28	treatment	treatment	NOUN
bptjm-38	22	29	methods	method	NOUN
bptjm-38	22	30	.	.	PUNCT
bptjm-38	23	1	this	this	DET
bptjm-38	23	2	paper	paper	NOUN
bptjm-38	23	3	will	will	AUX
bptjm-38	23	4	cover	cover	VERB
bptjm-38	23	5	the	the	DET
bptjm-38	23	6	underdevelopment	underdevelopment	NOUN
bptjm-38	23	7	of	of	ADP
bptjm-38	23	8	neurons	neuron	NOUN
bptjm-38	23	9	,	,	PUNCT
bptjm-38	23	10	impaired	impaired	ADJ
bptjm-38	23	11	neural	neural	ADJ
bptjm-38	23	12	migration	migration	NOUN
bptjm-38	23	13	,	,	PUNCT
bptjm-38	23	14	impaired	impaired	ADJ
bptjm-38	23	15	synaptogenesis	synaptogenesis	NOUN
bptjm-38	23	16	,	,	PUNCT
bptjm-38	23	17	and	and	CCONJ
bptjm-38	23	18	dendritic	dendritic	ADJ
bptjm-38	23	19	morphogenesis	morphogenesis	NOUN
bptjm-38	23	20	.	.	PUNCT
bptjm-38	24	1	8	8	NUM
bptjm-38	24	2	etiology	etiology	NOUN
bptjm-38	24	3	of	of	ADP
bptjm-38	24	4	autism	autism	NOUN
bptjm-38	24	5	spectrum	spectrum	VERB
bptjm-38	24	6	disorders	disorder	NOUN
bptjm-38	24	7	although	although	SCONJ
bptjm-38	24	8	the	the	DET
bptjm-38	24	9	details	detail	NOUN
bptjm-38	24	10	of	of	ADP
bptjm-38	24	11	the	the	DET
bptjm-38	24	12	origin	origin	NOUN
bptjm-38	24	13	of	of	ADP
bptjm-38	24	14	asd	asd	PROPN
bptjm-38	24	15	have	have	AUX
bptjm-38	24	16	not	not	PART
bptjm-38	24	17	yet	yet	ADV
bptjm-38	24	18	been	be	AUX
bptjm-38	24	19	discovered	discover	VERB
bptjm-38	24	20	,	,	PUNCT
bptjm-38	24	21	scientists	scientist	NOUN
bptjm-38	24	22	have	have	AUX
bptjm-38	24	23	come	come	VERB
bptjm-38	24	24	up	up	ADP
bptjm-38	24	25	with	with	ADP
bptjm-38	24	26	multiple	multiple	ADJ
bptjm-38	24	27	theories	theory	NOUN
bptjm-38	24	28	answering	answer	VERB
bptjm-38	24	29	the	the	DET
bptjm-38	24	30	question	question	NOUN
bptjm-38	24	31	of	of	ADP
bptjm-38	24	32	“	"	PUNCT
bptjm-38	24	33	how	how	SCONJ
bptjm-38	24	34	”	"	PUNCT
bptjm-38	24	35	asd	asd	PROPN
bptjm-38	24	36	comes	come	VERB
bptjm-38	24	37	to	to	PART
bptjm-38	24	38	be	be	AUX
bptjm-38	24	39	in	in	ADP
bptjm-38	24	40	individuals	individual	NOUN
bptjm-38	24	41	.	.	PUNCT
bptjm-38	25	1	one	one	NUM
bptjm-38	25	2	such	such	ADJ
bptjm-38	25	3	theory	theory	NOUN
bptjm-38	25	4	on	on	ADP
bptjm-38	25	5	the	the	DET
bptjm-38	25	6	pathophysiology	pathophysiology	NOUN
bptjm-38	25	7	of	of	ADP
bptjm-38	25	8	asd	asd	NOUN
bptjm-38	25	9	is	be	AUX
bptjm-38	25	10	linked	link	VERB
bptjm-38	25	11	to	to	ADP
bptjm-38	25	12	neural	neural	ADJ
bptjm-38	25	13	connectivity	connectivity	NOUN
bptjm-38	25	14	.	.	PUNCT
bptjm-38	26	1	in	in	ADP
bptjm-38	26	2	a	a	DET
bptjm-38	26	3	typical	typical	ADJ
bptjm-38	26	4	human	human	ADJ
bptjm-38	26	5	body	body	NOUN
bptjm-38	26	6	,	,	PUNCT
bptjm-38	26	7	an	an	DET
bptjm-38	26	8	individual	individual	NOUN
bptjm-38	26	9	develops	develop	VERB
bptjm-38	26	10	a	a	DET
bptjm-38	26	11	surplus	surplus	NOUN
bptjm-38	26	12	of	of	ADP
bptjm-38	26	13	neurons	neuron	NOUN
bptjm-38	26	14	where	where	SCONJ
bptjm-38	26	15	over	over	ADP
bptjm-38	26	16	time	time	NOUN
bptjm-38	26	17	,	,	PUNCT
bptjm-38	26	18	non	non	ADJ
bptjm-38	26	19	-	-	ADJ
bptjm-38	26	20	functional	functional	ADJ
bptjm-38	26	21	and	and	CCONJ
bptjm-38	26	22	unnecessary	unnecessary	ADJ
bptjm-38	26	23	neurons	neuron	NOUN
bptjm-38	26	24	are	be	AUX
bptjm-38	26	25	removed	remove	VERB
bptjm-38	26	26	through	through	ADP
bptjm-38	26	27	various	various	ADJ
bptjm-38	26	28	mechanisms	mechanism	NOUN
bptjm-38	26	29	.	.	PUNCT
bptjm-38	27	1	in	in	ADP
bptjm-38	27	2	patients	patient	NOUN
bptjm-38	27	3	who	who	PRON
bptjm-38	27	4	have	have	VERB
bptjm-38	27	5	asd	asd	NOUN
bptjm-38	27	6	,	,	PUNCT
bptjm-38	27	7	the	the	DET
bptjm-38	27	8	mechanism	mechanism	NOUN
bptjm-38	27	9	that	that	PRON
bptjm-38	27	10	targets	target	VERB
bptjm-38	27	11	the	the	DET
bptjm-38	27	12	elimination	elimination	NOUN
bptjm-38	27	13	of	of	ADP
bptjm-38	27	14	underdeveloped	underdeveloped	ADJ
bptjm-38	27	15	neurons	neuron	NOUN
bptjm-38	27	16	is	be	AUX
bptjm-38	27	17	damaged	damage	VERB
bptjm-38	27	18	.	.	PUNCT
bptjm-38	28	1	as	as	ADP
bptjm-38	28	2	a	a	DET
bptjm-38	28	3	result	result	NOUN
bptjm-38	28	4	,	,	PUNCT
bptjm-38	28	5	the	the	DET
bptjm-38	28	6	excess	excess	ADJ
bptjm-38	28	7	neurons	neuron	NOUN
bptjm-38	28	8	impair	impair	VERB
bptjm-38	28	9	the	the	DET
bptjm-38	28	10	shaping	shaping	NOUN
bptjm-38	28	11	and	and	CCONJ
bptjm-38	28	12	�	�	NOUN
bptjm-38	28	13	ne	ne	NOUN
bptjm-38	28	14	-	-	NOUN
bptjm-38	28	15	tuning	tuning	NOUN
bptjm-38	28	16	of	of	ADP
bptjm-38	28	17	neural	neural	ADJ
bptjm-38	28	18	circuits	circuit	NOUN
bptjm-38	28	19	.	.	PUNCT
bptjm-38	29	1	9	9	NUM
bptjm-38	29	2	another	another	DET
bptjm-38	29	3	theory	theory	NOUN
bptjm-38	29	4	focuses	focus	VERB
bptjm-38	29	5	on	on	ADP
bptjm-38	29	6	neural	neural	ADJ
bptjm-38	29	7	migration	migration	NOUN
bptjm-38	29	8	.	.	PUNCT
bptjm-38	30	1	similar	similar	ADJ
bptjm-38	30	2	to	to	ADP
bptjm-38	30	3	neural	neural	ADJ
bptjm-38	30	4	connectivity	connectivity	NOUN
bptjm-38	30	5	,	,	PUNCT
bptjm-38	30	6	neural	neural	ADJ
bptjm-38	30	7	migration	migration	NOUN
bptjm-38	30	8	also	also	ADV
bptjm-38	30	9	contributes	contribute	VERB
bptjm-38	30	10	to	to	ADP
bptjm-38	30	11	well	well	ADV
bptjm-38	30	12	-	-	PUNCT
bptjm-38	30	13	formed	form	VERB
bptjm-38	30	14	neural	neural	ADJ
bptjm-38	30	15	circuits	circuit	NOUN
bptjm-38	30	16	which	which	PRON
bptjm-38	30	17	aid	aid	NOUN
bptjm-38	30	18	in	in	ADP
bptjm-38	30	19	proper	proper	ADJ
bptjm-38	30	20	communication	communication	NOUN
bptjm-38	30	21	and	and	CCONJ
bptjm-38	30	22	other	other	ADJ
bptjm-38	30	23	neural	neural	ADJ
bptjm-38	30	24	behaviors	behavior	NOUN
bptjm-38	30	25	.	.	PUNCT
bptjm-38	31	1	in	in	ADP
bptjm-38	31	2	asd	asd	PROPN
bptjm-38	31	3	patients	patient	NOUN
bptjm-38	31	4	,	,	PUNCT
bptjm-38	31	5	the	the	DET
bptjm-38	31	6	misplacement	misplacement	NOUN
bptjm-38	31	7	of	of	ADP
bptjm-38	31	8	neurons	neuron	NOUN
bptjm-38	31	9	as	as	ADP
bptjm-38	31	10	a	a	DET
bptjm-38	31	11	result	result	NOUN
bptjm-38	31	12	of	of	ADP
bptjm-38	31	13	faulty	faulty	ADJ
bptjm-38	31	14	migration	migration	NOUN
bptjm-38	31	15	during	during	ADP
bptjm-38	31	16	development	development	NOUN
bptjm-38	31	17	increases	increase	VERB
bptjm-38	31	18	the	the	DET
bptjm-38	31	19	thickness	thickness	NOUN
bptjm-38	31	20	of	of	ADP
bptjm-38	31	21	the	the	DET
bptjm-38	31	22	cortex	cortex	NOUN
bptjm-38	31	23	and	and	CCONJ
bptjm-38	31	24	“	"	PUNCT
bptjm-38	31	25	smudges	smudge	NOUN
bptjm-38	31	26	”	"	PUNCT
bptjm-38	31	27	the	the	DET
bptjm-38	31	28	boundaries	boundary	NOUN
bptjm-38	31	29	of	of	ADP
bptjm-38	31	30	white	white	ADJ
bptjm-38	31	31	matter	matter	NOUN
bptjm-38	31	32	.	.	PUNCT
bptjm-38	32	1	this	this	DET
bptjm-38	32	2	mostly	mostly	ADV
bptjm-38	32	3	a	a	DET
bptjm-38	32	4	�	�	NOUN
bptjm-38	32	5	ects	ect	VERB
bptjm-38	32	6	the	the	DET
bptjm-38	32	7	frontal	frontal	ADJ
bptjm-38	32	8	and	and	CCONJ
bptjm-38	32	9	temporal	temporal	ADJ
bptjm-38	32	10	lobes	lobe	NOUN
bptjm-38	32	11	:	:	PUNCT
bptjm-38	32	12	key	key	ADJ
bptjm-38	32	13	elements	element	NOUN
bptjm-38	32	14	in	in	ADP
bptjm-38	32	15	processing	processing	NOUN
bptjm-38	32	16	language	language	NOUN
bptjm-38	32	17	and	and	CCONJ
bptjm-38	32	18	emotion	emotion	NOUN
bptjm-38	32	19	—	—	PUNCT
bptjm-38	32	20	functions	function	NOUN
bptjm-38	32	21	commonly	commonly	ADV
bptjm-38	32	22	found	find	VERB
bptjm-38	32	23	to	to	PART
bptjm-38	32	24	be	be	AUX
bptjm-38	32	25	impaired	impair	VERB
bptjm-38	32	26	in	in	ADP
bptjm-38	32	27	asd	asd	PROPN
bptjm-38	32	28	patients	patient	NOUN
bptjm-38	32	29	.	.	PUNCT
bptjm-38	33	1	9	9	NUM
bptjm-38	33	2	an	an	DET
bptjm-38	33	3	additional	additional	ADJ
bptjm-38	33	4	theory	theory	NOUN
bptjm-38	33	5	that	that	SCONJ
bptjm-38	33	6	de	de	PROPN
bptjm-38	33	7	�	�	NOUN
bptjm-38	33	8	nes	ne	VERB
bptjm-38	33	9	the	the	DET
bptjm-38	33	10	mechanism	mechanism	NOUN
bptjm-38	33	11	by	by	ADP
bptjm-38	33	12	which	which	PRON
bptjm-38	33	13	asd	asd	NOUN
bptjm-38	33	14	is	be	AUX
bptjm-38	33	15	established	establish	VERB
bptjm-38	33	16	focuses	focus	VERB
bptjm-38	33	17	on	on	ADP
bptjm-38	33	18	impaired	impaired	ADJ
bptjm-38	33	19	synaptogenesis	synaptogenesis	NOUN
bptjm-38	33	20	and	and	CCONJ
bptjm-38	33	21	dendritic	dendritic	ADJ
bptjm-38	33	22	morphogenesis	morphogenesis	NOUN
bptjm-38	33	23	.	.	PUNCT
bptjm-38	34	1	the	the	DET
bptjm-38	34	2	normal	normal	ADJ
bptjm-38	34	3	development	development	NOUN
bptjm-38	34	4	of	of	ADP
bptjm-38	34	5	synapses	synapsis	NOUN
bptjm-38	34	6	and	and	CCONJ
bptjm-38	34	7	dendrites	dendrite	NOUN
bptjm-38	34	8	entails	entail	VERB
bptjm-38	34	9	excess	excess	ADJ
bptjm-38	34	10	formation	formation	NOUN
bptjm-38	34	11	followed	follow	VERB
bptjm-38	34	12	by	by	ADP
bptjm-38	34	13	the	the	DET
bptjm-38	34	14	purging	purging	NOUN
bptjm-38	34	15	of	of	ADP
bptjm-38	34	16	faulty	faulty	ADJ
bptjm-38	34	17	expression	expression	NOUN
bptjm-38	34	18	.	.	PUNCT
bptjm-38	35	1	in	in	ADP
bptjm-38	35	2	patients	patient	NOUN
bptjm-38	35	3	with	with	ADP
bptjm-38	35	4	asd	asd	PROPN
bptjm-38	35	5	,	,	PUNCT
bptjm-38	35	6	the	the	DET
bptjm-38	35	7	suppression	suppression	NOUN
bptjm-38	35	8	mechanism	mechanism	NOUN
bptjm-38	35	9	responsible	responsible	ADJ
bptjm-38	35	10	for	for	ADP
bptjm-38	35	11	the	the	DET
bptjm-38	35	12	expulsion	expulsion	NOUN
bptjm-38	35	13	of	of	ADP
bptjm-38	35	14	berkeley	berkeley	PROPN
bptjm-38	35	15	pharma	pharma	PROPN
bptjm-38	35	16	tech	tech	NOUN
bptjm-38	35	17	journal	journal	NOUN
bptjm-38	35	18	of	of	ADP
bptjm-38	35	19	medicine	medicine	NOUN
bptjm-38	35	20	|	|	ADV
bptjm-38	35	21	12	12	NUM
bptjm-38	35	22	faulty	faulty	ADJ
bptjm-38	35	23	signaling	signal	VERB
bptjm-38	35	24	factors	factor	NOUN
bptjm-38	35	25	is	be	AUX
bptjm-38	35	26	impaired	impair	VERB
bptjm-38	35	27	.	.	PUNCT
bptjm-38	36	1	the	the	DET
bptjm-38	36	2	overwhelming	overwhelming	ADJ
bptjm-38	36	3	number	number	NOUN
bptjm-38	36	4	of	of	ADP
bptjm-38	36	5	defective	defective	ADJ
bptjm-38	36	6	synapses	synapsis	NOUN
bptjm-38	36	7	and	and	CCONJ
bptjm-38	36	8	dendrites	dendrite	NOUN
bptjm-38	36	9	damages	damage	VERB
bptjm-38	36	10	the	the	DET
bptjm-38	36	11	pathway	pathway	NOUN
bptjm-38	36	12	of	of	ADP
bptjm-38	36	13	signals	signal	NOUN
bptjm-38	36	14	within	within	ADP
bptjm-38	36	15	the	the	DET
bptjm-38	36	16	body	body	NOUN
bptjm-38	36	17	,	,	PUNCT
bptjm-38	36	18	resulting	result	VERB
bptjm-38	36	19	in	in	ADP
bptjm-38	36	20	the	the	DET
bptjm-38	36	21	core	core	NOUN
bptjm-38	36	22	symptoms	symptom	NOUN
bptjm-38	36	23	associated	associate	VERB
bptjm-38	36	24	with	with	ADP
bptjm-38	36	25	asd	asd	PROPN
bptjm-38	36	26	.	.	PROPN
bptjm-38	36	27	9	9	NUM
bptjm-38	36	28	key	key	ADJ
bptjm-38	36	29	genetic	genetic	ADJ
bptjm-38	36	30	factors	factor	NOUN
bptjm-38	36	31	the	the	DET
bptjm-38	36	32	build	build	NOUN
bptjm-38	36	33	-	-	PUNCT
bptjm-38	36	34	up	up	NOUN
bptjm-38	36	35	of	of	ADP
bptjm-38	36	36	faulty	faulty	ADJ
bptjm-38	36	37	factors	factor	NOUN
bptjm-38	36	38	as	as	ADP
bptjm-38	36	39	a	a	DET
bptjm-38	36	40	result	result	NOUN
bptjm-38	36	41	of	of	ADP
bptjm-38	36	42	impaired	impaired	ADJ
bptjm-38	36	43	mechanisms	mechanism	NOUN
bptjm-38	36	44	stems	stem	VERB
bptjm-38	36	45	from	from	ADP
bptjm-38	36	46	mutations	mutation	NOUN
bptjm-38	36	47	present	present	ADJ
bptjm-38	36	48	in	in	ADP
bptjm-38	36	49	the	the	DET
bptjm-38	36	50	genetic	genetic	ADJ
bptjm-38	36	51	factors	factor	NOUN
bptjm-38	36	52	that	that	PRON
bptjm-38	36	53	regulate	regulate	VERB
bptjm-38	36	54	such	such	ADJ
bptjm-38	36	55	processes	process	NOUN
bptjm-38	36	56	within	within	ADP
bptjm-38	36	57	the	the	DET
bptjm-38	36	58	human	human	ADJ
bptjm-38	36	59	body	body	NOUN
bptjm-38	36	60	.	.	PUNCT
bptjm-38	37	1	the	the	DET
bptjm-38	37	2	existence	existence	NOUN
bptjm-38	37	3	of	of	ADP
bptjm-38	37	4	these	these	DET
bptjm-38	37	5	mutations	mutation	NOUN
bptjm-38	37	6	is	be	AUX
bptjm-38	37	7	what	what	PRON
bptjm-38	37	8	has	have	AUX
bptjm-38	37	9	led	lead	VERB
bptjm-38	37	10	scientists	scientist	NOUN
bptjm-38	37	11	to	to	PART
bptjm-38	37	12	link	link	VERB
bptjm-38	37	13	asd	asd	NOUN
bptjm-38	37	14	to	to	ADP
bptjm-38	37	15	genetic	genetic	ADJ
bptjm-38	37	16	abnormalities	abnormality	NOUN
bptjm-38	37	17	.	.	PUNCT
bptjm-38	38	1	in	in	ADP
bptjm-38	38	2	typical	typical	ADJ
bptjm-38	38	3	human	human	ADJ
bptjm-38	38	4	physiology	physiology	NOUN
bptjm-38	38	5	,	,	PUNCT
bptjm-38	38	6	genetic	genetic	ADJ
bptjm-38	38	7	factors	factor	NOUN
bptjm-38	38	8	work	work	VERB
bptjm-38	38	9	in	in	ADP
bptjm-38	38	10	a	a	DET
bptjm-38	38	11	factory	factory	NOUN
bptjm-38	38	12	-	-	PUNCT
bptjm-38	38	13	line	line	NOUN
bptjm-38	38	14	fashion	fashion	NOUN
bptjm-38	38	15	to	to	PART
bptjm-38	38	16	facilitate	facilitate	VERB
bptjm-38	38	17	proper	proper	ADJ
bptjm-38	38	18	operations	operation	NOUN
bptjm-38	38	19	in	in	ADP
bptjm-38	38	20	the	the	DET
bptjm-38	38	21	formation	formation	NOUN
bptjm-38	38	22	of	of	ADP
bptjm-38	38	23	neurons	neuron	NOUN
bptjm-38	38	24	,	,	PUNCT
bptjm-38	38	25	synapses	synapsis	NOUN
bptjm-38	38	26	,	,	PUNCT
bptjm-38	38	27	and	and	CCONJ
bptjm-38	38	28	dendrites	dendrite	NOUN
bptjm-38	38	29	as	as	ADV
bptjm-38	38	30	well	well	ADV
bptjm-38	38	31	as	as	ADP
bptjm-38	38	32	key	key	ADJ
bptjm-38	38	33	neural	neural	ADJ
bptjm-38	38	34	factors	factor	NOUN
bptjm-38	38	35	.	.	PUNCT
bptjm-38	39	1	the	the	DET
bptjm-38	39	2	malfunction	malfunction	NOUN
bptjm-38	39	3	of	of	ADP
bptjm-38	39	4	any	any	DET
bptjm-38	39	5	genetic	genetic	ADJ
bptjm-38	39	6	factor	factor	NOUN
bptjm-38	39	7	in	in	ADP
bptjm-38	39	8	the	the	DET
bptjm-38	39	9	factory	factory	NOUN
bptjm-38	39	10	line	line	NOUN
bptjm-38	39	11	creates	create	VERB
bptjm-38	39	12	a	a	DET
bptjm-38	39	13	“	"	PUNCT
bptjm-38	39	14	domino	domino	NOUN
bptjm-38	39	15	e	e	NOUN
bptjm-38	39	16	�	�	PROPN
bptjm-38	39	17	ect	ect	NOUN
bptjm-38	39	18	”	"	PUNCT
bptjm-38	39	19	that	that	PRON
bptjm-38	39	20	leads	lead	VERB
bptjm-38	39	21	to	to	ADP
bptjm-38	39	22	forms	form	NOUN
bptjm-38	39	23	of	of	ADP
bptjm-38	39	24	neurobehavioral	neurobehavioral	ADJ
bptjm-38	39	25	impairment	impairment	NOUN
bptjm-38	39	26	associated	associate	VERB
bptjm-38	39	27	with	with	ADP
bptjm-38	39	28	asd	asd	PROPN
bptjm-38	39	29	.	.	PUNCT
bptjm-38	40	1	although	although	SCONJ
bptjm-38	40	2	there	there	PRON
bptjm-38	40	3	are	be	VERB
bptjm-38	40	4	many	many	ADJ
bptjm-38	40	5	di	di	NOUN
bptjm-38	40	6	�	�	PROPN
bptjm-38	40	7	erent	erent	NOUN
bptjm-38	40	8	factors	factor	NOUN
bptjm-38	40	9	that	that	PRON
bptjm-38	40	10	contribute	contribute	VERB
bptjm-38	40	11	to	to	ADP
bptjm-38	40	12	proper	proper	ADJ
bptjm-38	40	13	neurobehavior	neurobehavior	NOUN
bptjm-38	40	14	,	,	PUNCT
bptjm-38	40	15	this	this	DET
bptjm-38	40	16	paper	paper	NOUN
bptjm-38	40	17	focuses	focus	VERB
bptjm-38	40	18	on	on	ADP
bptjm-38	40	19	the	the	DET
bptjm-38	40	20	mutation	mutation	NOUN
bptjm-38	40	21	of	of	ADP
bptjm-38	40	22	three	three	NUM
bptjm-38	40	23	in	in	ADP
bptjm-38	40	24	particular	particular	ADJ
bptjm-38	40	25	:	:	PUNCT
bptjm-38	40	26	tcf4	tcf4	ADJ
bptjm-38	40	27	,	,	PUNCT
bptjm-38	40	28	reln	reln	NOUN
bptjm-38	40	29	and	and	CCONJ
bptjm-38	40	30	mecp2	mecp2	NOUN
bptjm-38	40	31	.	.	PUNCT
bptjm-38	41	1	10	10	NUM
bptjm-38	41	2	,	,	PUNCT
bptjm-38	41	3	11	11	NUM
bptjm-38	41	4	,	,	PUNCT
bptjm-38	41	5	12	12	NUM
bptjm-38	41	6	,	,	PUNCT
bptjm-38	41	7	13	13	NUM
bptjm-38	41	8	,	,	PUNCT
bptjm-38	41	9	14	14	NUM
bptjm-38	41	10	studies	study	NOUN
bptjm-38	41	11	:	:	PUNCT
bptjm-38	41	12	linking	link	VERB
bptjm-38	41	13	etiology	etiology	NOUN
bptjm-38	41	14	of	of	ADP
bptjm-38	41	15	asd	asd	NOUN
bptjm-38	41	16	and	and	CCONJ
bptjm-38	41	17	mutations	mutation	NOUN
bptjm-38	41	18	of	of	ADP
bptjm-38	41	19	‘	'	PUNCT
bptjm-38	41	20	key	key	ADJ
bptjm-38	41	21	genetic	genetic	ADJ
bptjm-38	41	22	factors	factor	NOUN
bptjm-38	41	23	’	'	PUNCT
bptjm-38	41	24	4.1	4.1	NUM
bptjm-38	41	25	tcf4	tcf4	ADJ
bptjm-38	41	26	gene	gene	NOUN
bptjm-38	41	27	study	study	NOUN
bptjm-38	41	28	transcription	transcription	NOUN
bptjm-38	41	29	factor	factor	NOUN
bptjm-38	41	30	4	4	NUM
bptjm-38	41	31	(	(	PUNCT
bptjm-38	41	32	tcf4	tcf4	ADJ
bptjm-38	41	33	)	)	PUNCT
bptjm-38	41	34	is	be	AUX
bptjm-38	41	35	responsible	responsible	ADJ
bptjm-38	41	36	for	for	ADP
bptjm-38	41	37	encoding	encode	VERB
bptjm-38	41	38	a	a	DET
bptjm-38	41	39	helix	helix	ADJ
bptjm-38	41	40	-	-	PUNCT
bptjm-38	41	41	loop	loop	NOUN
bptjm-38	41	42	-	-	PUNCT
bptjm-38	41	43	helix	helix	NOUN
bptjm-38	41	44	transcription	transcription	NOUN
bptjm-38	41	45	factor	factor	NOUN
bptjm-38	41	46	expressed	express	VERB
bptjm-38	41	47	most	most	ADV
bptjm-38	41	48	often	often	ADV
bptjm-38	41	49	during	during	ADP
bptjm-38	41	50	brain	brain	NOUN
bptjm-38	41	51	development	development	NOUN
bptjm-38	41	52	.	.	PUNCT
bptjm-38	42	1	an	an	DET
bptjm-38	42	2	alteration	alteration	NOUN
bptjm-38	42	3	in	in	ADP
bptjm-38	42	4	tcf4	tcf4	ADJ
bptjm-38	42	5	causes	cause	VERB
bptjm-38	42	6	pitt	pitt	PROPN
bptjm-38	42	7	-	-	PUNCT
bptjm-38	42	8	hopkins	hopkins	PROPN
bptjm-38	42	9	syndrome	syndrome	NOUN
bptjm-38	42	10	(	(	PUNCT
bptjm-38	42	11	pths	pth	NOUN
bptjm-38	42	12	):	):	PUNCT
bptjm-38	42	13	a	a	DET
bptjm-38	42	14	disorder	disorder	NOUN
bptjm-38	42	15	characterized	characterize	VERB
bptjm-38	42	16	by	by	ADP
bptjm-38	42	17	profound	profound	ADJ
bptjm-38	42	18	cognitive	cognitive	ADJ
bptjm-38	42	19	and	and	CCONJ
bptjm-38	42	20	motor	motor	NOUN
bptjm-38	42	21	disabilities	disability	NOUN
bptjm-38	42	22	and	and	CCONJ
bptjm-38	42	23	de	de	PROPN
bptjm-38	42	24	�	�	NOUN
bptjm-38	42	25	ned	ne	VERB
bptjm-38	42	26	under	under	ADP
bptjm-38	42	27	the	the	DET
bptjm-38	42	28	umbrella	umbrella	NOUN
bptjm-38	42	29	de	de	NOUN
bptjm-38	42	30	�	�	NOUN
bptjm-38	42	31	nition	nition	NOUN
bptjm-38	42	32	of	of	ADP
bptjm-38	42	33	autism	autism	NOUN
bptjm-38	42	34	disorders	disorder	NOUN
bptjm-38	42	35	.	.	PUNCT
bptjm-38	43	1	patients	patient	NOUN
bptjm-38	43	2	with	with	ADP
bptjm-38	43	3	pths	pth	NOUN
bptjm-38	43	4	have	have	VERB
bptjm-38	43	5	mutations	mutation	NOUN
bptjm-38	43	6	that	that	PRON
bptjm-38	43	7	either	either	CCONJ
bptjm-38	43	8	knock	knock	VERB
bptjm-38	43	9	out	out	ADP
bptjm-38	43	10	the	the	DET
bptjm-38	43	11	functional	functional	ADJ
bptjm-38	43	12	tcf4	tcf4	ADJ
bptjm-38	43	13	gene	gene	NOUN
bptjm-38	43	14	,	,	PUNCT
bptjm-38	43	15	eliminate	eliminate	VERB
bptjm-38	43	16	its	its	PRON
bptjm-38	43	17	essential	essential	ADJ
bptjm-38	43	18	dna	dna	NOUN
bptjm-38	43	19	-	-	PUNCT
bptjm-38	43	20	binding	bind	VERB
bptjm-38	43	21	domain	domain	NOUN
bptjm-38	43	22	,	,	PUNCT
bptjm-38	43	23	or	or	CCONJ
bptjm-38	43	24	impact	impact	VERB
bptjm-38	43	25	one	one	NUM
bptjm-38	43	26	of	of	ADP
bptjm-38	43	27	its	its	PRON
bptjm-38	43	28	transcriptional	transcriptional	ADJ
bptjm-38	43	29	activation	activation	NOUN
bptjm-38	43	30	domains	domain	NOUN
bptjm-38	43	31	.	.	PUNCT
bptjm-38	44	1	10	10	NUM
bptjm-38	44	2	the	the	DET
bptjm-38	44	3	university	university	PROPN
bptjm-38	44	4	of	of	ADP
bptjm-38	44	5	california	california	PROPN
bptjm-38	44	6	san	san	PROPN
bptjm-38	44	7	diego	diego	PROPN
bptjm-38	44	8	medical	medical	PROPN
bptjm-38	44	9	school	school	PROPN
bptjm-38	44	10	sought	seek	VERB
bptjm-38	44	11	to	to	PART
bptjm-38	44	12	understand	understand	VERB
bptjm-38	44	13	how	how	SCONJ
bptjm-38	44	14	a	a	DET
bptjm-38	44	15	mutated	mutate	VERB
bptjm-38	44	16	tcf4	tcf4	ADJ
bptjm-38	44	17	gene	gene	NOUN
bptjm-38	44	18	results	result	NOUN
bptjm-38	44	19	in	in	ADP
bptjm-38	44	20	this	this	DET
bptjm-38	44	21	form	form	NOUN
bptjm-38	44	22	of	of	ADP
bptjm-38	44	23	autism	autism	NOUN
bptjm-38	44	24	.	.	PUNCT
bptjm-38	45	1	11	11	NUM
bptjm-38	45	2	,	,	PUNCT
bptjm-38	45	3	12	12	NUM
bptjm-38	45	4	to	to	ADP
bptjm-38	45	5	berkeley	berkeley	PROPN
bptjm-38	45	6	pharma	pharma	PROPN
bptjm-38	45	7	tech	tech	NOUN
bptjm-38	45	8	journal	journal	NOUN
bptjm-38	45	9	of	of	ADP
bptjm-38	45	10	medicine	medicine	NOUN
bptjm-38	45	11	|	|	ADV
bptjm-38	45	12	13	13	NUM
bptjm-38	45	13	explore	explore	VERB
bptjm-38	45	14	this	this	DET
bptjm-38	45	15	idea	idea	NOUN
bptjm-38	45	16	,	,	PUNCT
bptjm-38	45	17	scientists	scientist	NOUN
bptjm-38	45	18	used	use	VERB
bptjm-38	45	19	pluripotent	pluripotent	ADJ
bptjm-38	45	20	stem	stem	NOUN
bptjm-38	45	21	cells	cell	NOUN
bptjm-38	45	22	(	(	PUNCT
bptjm-38	45	23	ipsc	ipsc	NOUN
bptjm-38	45	24	)	)	PUNCT
bptjm-38	45	25	,	,	PUNCT
bptjm-38	45	26	adult	adult	NOUN
bptjm-38	45	27	somatic	somatic	ADJ
bptjm-38	45	28	cells	cell	NOUN
bptjm-38	45	29	that	that	PRON
bptjm-38	45	30	have	have	AUX
bptjm-38	45	31	been	be	AUX
bptjm-38	45	32	reprogrammed	reprogramme	VERB
bptjm-38	45	33	to	to	PART
bptjm-38	45	34	be	be	AUX
bptjm-38	45	35	in	in	ADP
bptjm-38	45	36	an	an	DET
bptjm-38	45	37	embryonic	embryonic	ADJ
bptjm-38	45	38	state	state	NOUN
bptjm-38	45	39	,	,	PUNCT
bptjm-38	45	40	of	of	ADP
bptjm-38	45	41	5	5	NUM
bptjm-38	45	42	patients	patient	NOUN
bptjm-38	45	43	with	with	ADP
bptjm-38	45	44	pths	pth	NOUN
bptjm-38	45	45	.	.	PUNCT
bptjm-38	46	1	12	12	NUM
bptjm-38	46	2	to	to	PART
bptjm-38	46	3	guarantee	guarantee	VERB
bptjm-38	46	4	a	a	DET
bptjm-38	46	5	controlled	control	VERB
bptjm-38	46	6	experiment	experiment	NOUN
bptjm-38	46	7	,	,	PUNCT
bptjm-38	46	8	mutated	mutate	VERB
bptjm-38	46	9	tcf4	tcf4	PROPN
bptjm-38	46	10	was	be	AUX
bptjm-38	46	11	the	the	DET
bptjm-38	46	12	only	only	ADJ
bptjm-38	46	13	chromosomal	chromosomal	ADJ
bptjm-38	46	14	abnormality	abnormality	NOUN
bptjm-38	46	15	present	present	ADJ
bptjm-38	46	16	in	in	ADP
bptjm-38	46	17	the	the	DET
bptjm-38	46	18	experimental	experimental	ADJ
bptjm-38	46	19	pths	pth	NOUN
bptjm-38	46	20	ipcs	ipc	NOUN
bptjm-38	46	21	lines	line	NOUN
bptjm-38	46	22	.	.	PUNCT
bptjm-38	47	1	these	these	DET
bptjm-38	47	2	ipsc	ipsc	PROPN
bptjm-38	47	3	lines	line	NOUN
bptjm-38	47	4	were	be	AUX
bptjm-38	47	5	used	use	VERB
bptjm-38	47	6	to	to	PART
bptjm-38	47	7	generate	generate	VERB
bptjm-38	47	8	neuron	neuron	NOUN
bptjm-38	47	9	progenitor	progenitor	NOUN
bptjm-38	47	10	cells	cell	NOUN
bptjm-38	47	11	(	(	PUNCT
bptjm-38	47	12	npcs	npc	NOUN
bptjm-38	47	13	)	)	PUNCT
bptjm-38	47	14	,	,	PUNCT
bptjm-38	47	15	the	the	DET
bptjm-38	47	16	precursors	precursor	NOUN
bptjm-38	47	17	of	of	ADP
bptjm-38	47	18	most	most	ADJ
bptjm-38	47	19	of	of	ADP
bptjm-38	47	20	the	the	DET
bptjm-38	47	21	neurons	neuron	NOUN
bptjm-38	47	22	that	that	PRON
bptjm-38	47	23	make	make	VERB
bptjm-38	47	24	up	up	ADP
bptjm-38	47	25	the	the	DET
bptjm-38	47	26	central	central	ADJ
bptjm-38	47	27	nervous	nervous	ADJ
bptjm-38	47	28	system	system	NOUN
bptjm-38	47	29	.	.	PUNCT
bptjm-38	48	1	the	the	DET
bptjm-38	48	2	pths	pth	NOUN
bptjm-38	48	3	npcs	npc	NOUN
bptjm-38	48	4	,	,	PUNCT
bptjm-38	48	5	produced	produce	VERB
bptjm-38	48	6	by	by	ADP
bptjm-38	48	7	the	the	DET
bptjm-38	48	8	pths	pth	NOUN
bptjm-38	48	9	ipsc	ipsc	NOUN
bptjm-38	48	10	lines	line	NOUN
bptjm-38	48	11	,	,	PUNCT
bptjm-38	48	12	presented	present	VERB
bptjm-38	48	13	a	a	DET
bptjm-38	48	14	reduction	reduction	NOUN
bptjm-38	48	15	in	in	ADP
bptjm-38	48	16	tcf4	tcf4	ADJ
bptjm-38	48	17	expression	expression	NOUN
bptjm-38	48	18	.	.	PUNCT
bptjm-38	49	1	this	this	PRON
bptjm-38	49	2	resulted	result	VERB
bptjm-38	49	3	in	in	ADP
bptjm-38	49	4	neurons	neuron	NOUN
bptjm-38	49	5	with	with	ADP
bptjm-38	49	6	altered	altered	ADJ
bptjm-38	49	7	expressions	expression	NOUN
bptjm-38	49	8	of	of	ADP
bptjm-38	49	9	cntnap2	cntnap2	PROPN
bptjm-38	49	10	and	and	CCONJ
bptjm-38	49	11	kcnq1	kcnq1	PROPN
bptjm-38	49	12	,	,	PUNCT
bptjm-38	49	13	which	which	PRON
bptjm-38	49	14	are	be	AUX
bptjm-38	49	15	usually	usually	ADV
bptjm-38	49	16	regulated	regulate	VERB
bptjm-38	49	17	by	by	ADP
bptjm-38	49	18	the	the	DET
bptjm-38	49	19	tcf4	tcf4	ADJ
bptjm-38	49	20	gene	gene	NOUN
bptjm-38	49	21	.	.	PUNCT
bptjm-38	50	1	10,11	10,11	NOUN
bptjm-38	50	2	for	for	ADP
bptjm-38	50	3	further	further	ADJ
bptjm-38	50	4	analysis	analysis	NOUN
bptjm-38	50	5	,	,	PUNCT
bptjm-38	50	6	scientists	scientist	NOUN
bptjm-38	50	7	used	use	VERB
bptjm-38	50	8	the	the	DET
bptjm-38	50	9	control	control	NOUN
bptjm-38	50	10	and	and	CCONJ
bptjm-38	50	11	pths	pth	VERB
bptjm-38	50	12	ipscs	ipscs	NOUN
bptjm-38	50	13	line	line	NOUN
bptjm-38	50	14	to	to	PART
bptjm-38	50	15	create	create	VERB
bptjm-38	50	16	brain	brain	NOUN
bptjm-38	50	17	cortical	cortical	ADJ
bptjm-38	50	18	(	(	PUNCT
bptjm-38	50	19	cto	cto	ADJ
bptjm-38	50	20	)	)	PUNCT
bptjm-38	50	21	organoids	organoid	NOUN
bptjm-38	50	22	,	,	PUNCT
bptjm-38	50	23	an	an	DET
bptjm-38	50	24	arti	arti	PROPN
bptjm-38	50	25	�	�	PROPN
bptjm-38	50	26	cially	cially	ADV
bptjm-38	50	27	manufactured	manufacture	VERB
bptjm-38	50	28	tissue	tissue	NOUN
bptjm-38	50	29	resembling	resemble	VERB
bptjm-38	50	30	the	the	DET
bptjm-38	50	31	functionality	functionality	NOUN
bptjm-38	50	32	and	and	CCONJ
bptjm-38	50	33	structure	structure	NOUN
bptjm-38	50	34	of	of	ADP
bptjm-38	50	35	the	the	DET
bptjm-38	50	36	human	human	ADJ
bptjm-38	50	37	brain	brain	NOUN
bptjm-38	50	38	.	.	PUNCT
bptjm-38	51	1	11	11	NUM
bptjm-38	51	2	in	in	ADP
bptjm-38	51	3	comparison	comparison	NOUN
bptjm-38	51	4	to	to	ADP
bptjm-38	51	5	the	the	DET
bptjm-38	51	6	control	control	NOUN
bptjm-38	51	7	organoid	organoid	PROPN
bptjm-38	51	8	’s	’s	PART
bptjm-38	51	9	normal	normal	ADJ
bptjm-38	51	10	spheroid	spheroid	NOUN
bptjm-38	51	11	form	form	NOUN
bptjm-38	51	12	,	,	PUNCT
bptjm-38	51	13	the	the	DET
bptjm-38	51	14	pths	pth	NOUN
bptjm-38	51	15	cto	cto	PROPN
bptjm-38	51	16	organoid	organoid	PROPN
bptjm-38	51	17	presented	present	VERB
bptjm-38	51	18	an	an	DET
bptjm-38	51	19	abnormal	abnormal	ADJ
bptjm-38	51	20	structure	structure	NOUN
bptjm-38	51	21	and	and	CCONJ
bptjm-38	51	22	size	size	NOUN
bptjm-38	51	23	.	.	PUNCT
bptjm-38	52	1	through	through	ADP
bptjm-38	52	2	single	single	ADJ
bptjm-38	52	3	cell	cell	NOUN
bptjm-38	52	4	rna	rna	NOUN
bptjm-38	52	5	sequencing	sequencing	NOUN
bptjm-38	52	6	,	,	PUNCT
bptjm-38	52	7	it	it	PRON
bptjm-38	52	8	was	be	AUX
bptjm-38	52	9	concluded	conclude	VERB
bptjm-38	52	10	that	that	SCONJ
bptjm-38	52	11	the	the	DET
bptjm-38	52	12	pths	pth	NOUN
bptjm-38	52	13	cortical	cortical	ADJ
bptjm-38	52	14	organoid	organoid	NOUN
bptjm-38	52	15	’s	’s	PART
bptjm-38	52	16	diminished	diminish	VERB
bptjm-38	52	17	size	size	NOUN
bptjm-38	52	18	and	and	CCONJ
bptjm-38	52	19	characteristic	characteristic	ADJ
bptjm-38	52	20	factors	factor	NOUN
bptjm-38	52	21	were	be	AUX
bptjm-38	52	22	the	the	DET
bptjm-38	52	23	result	result	NOUN
bptjm-38	52	24	of	of	ADP
bptjm-38	52	25	a	a	DET
bptjm-38	52	26	loss	loss	NOUN
bptjm-38	52	27	of	of	ADP
bptjm-38	52	28	cellular	cellular	ADJ
bptjm-38	52	29	diversity	diversity	NOUN
bptjm-38	52	30	.	.	PUNCT
bptjm-38	53	1	to	to	PART
bptjm-38	53	2	make	make	VERB
bptjm-38	53	3	certain	certain	ADJ
bptjm-38	53	4	that	that	SCONJ
bptjm-38	53	5	this	this	DET
bptjm-38	53	6	loss	loss	NOUN
bptjm-38	53	7	was	be	AUX
bptjm-38	53	8	not	not	PART
bptjm-38	53	9	a	a	DET
bptjm-38	53	10	result	result	NOUN
bptjm-38	53	11	of	of	ADP
bptjm-38	53	12	mispatterning	mispatterne	VERB
bptjm-38	53	13	,	,	PUNCT
bptjm-38	53	14	the	the	DET
bptjm-38	53	15	uc	uc	PROPN
bptjm-38	53	16	san	san	PROPN
bptjm-38	53	17	diego	diego	PROPN
bptjm-38	53	18	team	team	NOUN
bptjm-38	53	19	performed	perform	VERB
bptjm-38	53	20	single	single	ADJ
bptjm-38	53	21	cell	cell	NOUN
bptjm-38	53	22	transcriptomic	transcriptomic	ADJ
bptjm-38	53	23	testing	testing	NOUN
bptjm-38	53	24	on	on	ADP
bptjm-38	53	25	the	the	DET
bptjm-38	53	26	organoids	organoid	NOUN
bptjm-38	53	27	.	.	PUNCT
bptjm-38	54	1	the	the	DET
bptjm-38	54	2	telencephalic	telencephalic	NOUN
bptjm-38	54	3	marker	marker	NOUN
bptjm-38	54	4	,	,	PUNCT
bptjm-38	54	5	foxg1	foxg1	NOUN
bptjm-38	54	6	,	,	PUNCT
bptjm-38	54	7	expression	expression	NOUN
bptjm-38	54	8	analysis	analysis	NOUN
bptjm-38	54	9	in	in	ADP
bptjm-38	54	10	combination	combination	NOUN
bptjm-38	54	11	with	with	ADP
bptjm-38	54	12	the	the	DET
bptjm-38	54	13	single	single	ADJ
bptjm-38	54	14	cell	cell	NOUN
bptjm-38	54	15	rna	rna	NOUN
bptjm-38	54	16	sequencing	sequencing	NOUN
bptjm-38	54	17	concluded	conclude	VERB
bptjm-38	54	18	that	that	SCONJ
bptjm-38	54	19	the	the	DET
bptjm-38	54	20	loss	loss	NOUN
bptjm-38	54	21	of	of	ADP
bptjm-38	54	22	cell	cell	NOUN
bptjm-38	54	23	diversity	diversity	NOUN
bptjm-38	54	24	in	in	ADP
bptjm-38	54	25	the	the	DET
bptjm-38	54	26	pths	pth	NOUN
bptjm-38	54	27	cortical	cortical	ADJ
bptjm-38	54	28	organoid	organoid	NOUN
bptjm-38	54	29	was	be	AUX
bptjm-38	54	30	due	due	ADJ
bptjm-38	54	31	to	to	ADP
bptjm-38	54	32	a	a	DET
bptjm-38	54	33	higher	high	ADJ
bptjm-38	54	34	percentage	percentage	NOUN
bptjm-38	54	35	of	of	ADP
bptjm-38	54	36	underdeveloped	underdeveloped	ADJ
bptjm-38	54	37	neurons	neuron	NOUN
bptjm-38	54	38	,	,	PUNCT
bptjm-38	54	39	known	know	VERB
bptjm-38	54	40	as	as	ADP
bptjm-38	54	41	neural	neural	ADJ
bptjm-38	54	42	progenitor	progenitor	NOUN
bptjm-38	54	43	cells	cell	NOUN
bptjm-38	54	44	(	(	PUNCT
bptjm-38	54	45	npc	npc	NOUN
bptjm-38	54	46	)	)	PUNCT
bptjm-38	54	47	.	.	PUNCT
bptjm-38	55	1	the	the	DET
bptjm-38	55	2	e	e	NOUN
bptjm-38	55	3	�	�	PROPN
bptjm-38	55	4	ects	ect	NOUN
bptjm-38	55	5	of	of	ADP
bptjm-38	55	6	the	the	DET
bptjm-38	55	7	mutated	mutate	VERB
bptjm-38	55	8	genetic	genetic	ADJ
bptjm-38	55	9	factor	factor	NOUN
bptjm-38	55	10	tcf4	tcf4	ADJ
bptjm-38	55	11	on	on	ADP
bptjm-38	55	12	the	the	DET
bptjm-38	55	13	brain	brain	NOUN
bptjm-38	55	14	correlates	correlate	VERB
bptjm-38	55	15	to	to	ADP
bptjm-38	55	16	the	the	DET
bptjm-38	55	17	neural	neural	ADJ
bptjm-38	55	18	connectivity	connectivity	NOUN
bptjm-38	55	19	theory	theory	NOUN
bptjm-38	55	20	.	.	PUNCT
bptjm-38	56	1	this	this	DET
bptjm-38	56	2	theory	theory	NOUN
bptjm-38	56	3	posits	posit	VERB
bptjm-38	56	4	that	that	SCONJ
bptjm-38	56	5	a	a	DET
bptjm-38	56	6	surplus	surplus	NOUN
bptjm-38	56	7	of	of	ADP
bptjm-38	56	8	de	de	X
bptjm-38	56	9	�	�	PROPN
bptjm-38	56	10	cient	cient	NOUN
bptjm-38	56	11	development	development	NOUN
bptjm-38	56	12	of	of	ADP
bptjm-38	56	13	neurons	neuron	NOUN
bptjm-38	56	14	due	due	ADJ
bptjm-38	56	15	to	to	ADP
bptjm-38	56	16	impaired	impaired	ADJ
bptjm-38	56	17	progenitor	progenitor	NOUN
bptjm-38	56	18	proliferation	proliferation	NOUN
bptjm-38	56	19	,	,	PUNCT
bptjm-38	56	20	alters	alter	VERB
bptjm-38	56	21	the	the	DET
bptjm-38	56	22	function	function	NOUN
bptjm-38	56	23	and	and	CCONJ
bptjm-38	56	24	structure	structure	NOUN
bptjm-38	56	25	of	of	ADP
bptjm-38	56	26	the	the	DET
bptjm-38	56	27	brain	brain	NOUN
bptjm-38	56	28	and	and	CCONJ
bptjm-38	56	29	its	its	PRON
bptjm-38	56	30	neural	neural	ADJ
bptjm-38	56	31	circuits	circuit	NOUN
bptjm-38	56	32	responsible	responsible	ADJ
bptjm-38	56	33	for	for	ADP
bptjm-38	56	34	functions	function	NOUN
bptjm-38	56	35	such	such	ADJ
bptjm-38	56	36	as	as	ADP
bptjm-38	56	37	communication	communication	NOUN
bptjm-38	56	38	and	and	CCONJ
bptjm-38	56	39	behavior	behavior	NOUN
bptjm-38	56	40	.	.	PUNCT
bptjm-38	57	1	this	this	DET
bptjm-38	57	2	excess	excess	NOUN
bptjm-38	57	3	of	of	ADP
bptjm-38	57	4	underdeveloped	underdeveloped	ADJ
bptjm-38	57	5	neurons	neuron	NOUN
bptjm-38	57	6	prevents	prevent	VERB
bptjm-38	57	7	the	the	DET
bptjm-38	57	8	idealized	idealized	ADJ
bptjm-38	57	9	function	function	NOUN
bptjm-38	57	10	of	of	ADP
bptjm-38	57	11	neural	neural	ADJ
bptjm-38	57	12	circuits	circuit	NOUN
bptjm-38	57	13	.	.	PUNCT
bptjm-38	58	1	11	11	NUM
bptjm-38	58	2	with	with	ADP
bptjm-38	58	3	an	an	DET
bptjm-38	58	4	understanding	understanding	NOUN
bptjm-38	58	5	of	of	ADP
bptjm-38	58	6	the	the	DET
bptjm-38	58	7	�	�	PROPN
bptjm-38	58	8	rst	rst	PROPN
bptjm-38	58	9	domino	domino	NOUN
bptjm-38	58	10	in	in	ADP
bptjm-38	58	11	the	the	DET
bptjm-38	58	12	developmental	developmental	ADJ
bptjm-38	58	13	pathway	pathway	NOUN
bptjm-38	58	14	of	of	ADP
bptjm-38	58	15	pths	pth	NOUN
bptjm-38	58	16	,	,	PUNCT
bptjm-38	58	17	the	the	DET
bptjm-38	58	18	uc	uc	PROPN
bptjm-38	58	19	san	san	PROPN
bptjm-38	58	20	diego	diego	PROPN
bptjm-38	58	21	team	team	NOUN
bptjm-38	58	22	focused	focus	VERB
bptjm-38	58	23	on	on	ADP
bptjm-38	58	24	abolishing	abolish	VERB
bptjm-38	58	25	its	its	PRON
bptjm-38	58	26	molecular	molecular	ADJ
bptjm-38	58	27	and	and	CCONJ
bptjm-38	58	28	cellular	cellular	ADJ
bptjm-38	58	29	characteristics	characteristic	NOUN
bptjm-38	58	30	by	by	ADP
bptjm-38	58	31	correcting	correct	VERB
bptjm-38	58	32	the	the	DET
bptjm-38	58	33	expression	expression	NOUN
bptjm-38	58	34	of	of	ADP
bptjm-38	58	35	the	the	DET
bptjm-38	58	36	tcf4	tcf4	ADJ
bptjm-38	58	37	gene	gene	NOUN
bptjm-38	58	38	.	.	PUNCT
bptjm-38	59	1	the	the	DET
bptjm-38	59	2	�	�	PROPN
bptjm-38	59	3	rst	rst	PROPN
bptjm-38	59	4	method	method	NOUN
bptjm-38	59	5	used	use	VERB
bptjm-38	59	6	two	two	NUM
bptjm-38	59	7	viral	viral	ADJ
bptjm-38	59	8	vectors	vector	NOUN
bptjm-38	59	9	and	and	CCONJ
bptjm-38	59	10	a	a	DET
bptjm-38	59	11	crispr	crispr	NOUN
bptjm-38	59	12	based	base	VERB
bptjm-38	59	13	transepigenetic	transepigenetic	ADJ
bptjm-38	59	14	berkeley	berkeley	PROPN
bptjm-38	59	15	pharma	pharma	PROPN
bptjm-38	59	16	tech	tech	NOUN
bptjm-38	59	17	journal	journal	NOUN
bptjm-38	59	18	of	of	ADP
bptjm-38	59	19	medicine	medicine	NOUN
bptjm-38	59	20	|	|	ADV
bptjm-38	59	21	14	14	NUM
bptjm-38	59	22	strategy	strategy	NOUN
bptjm-38	59	23	.	.	PUNCT
bptjm-38	60	1	all	all	DET
bptjm-38	60	2	three	three	NUM
bptjm-38	60	3	cassettes	cassette	NOUN
bptjm-38	60	4	worked	work	VERB
bptjm-38	60	5	together	together	ADV
bptjm-38	60	6	to	to	PART
bptjm-38	60	7	enhance	enhance	VERB
bptjm-38	60	8	the	the	DET
bptjm-38	60	9	transcription	transcription	NOUN
bptjm-38	60	10	of	of	ADP
bptjm-38	60	11	the	the	DET
bptjm-38	60	12	tcf4	tcf4	ADJ
bptjm-38	60	13	gene	gene	NOUN
bptjm-38	60	14	,	,	PUNCT
bptjm-38	60	15	ultimately	ultimately	ADV
bptjm-38	60	16	correcting	correct	VERB
bptjm-38	60	17	the	the	DET
bptjm-38	60	18	downstream	downstream	ADJ
bptjm-38	60	19	targets	target	NOUN
bptjm-38	60	20	.	.	PUNCT
bptjm-38	61	1	11	11	NUM
bptjm-38	61	2	figure	figure	NOUN
bptjm-38	61	3	1	1	NUM
bptjm-38	61	4	:	:	PUNCT
bptjm-38	61	5	crispr	crispr	NOUN
bptjm-38	61	6	-	-	PUNCT
bptjm-38	61	7	based	base	VERB
bptjm-38	61	8	transepigenetic	transepigenetic	ADJ
bptjm-38	61	9	strategy	strategy	NOUN
bptjm-38	61	10	for	for	ADP
bptjm-38	61	11	correction	correction	NOUN
bptjm-38	61	12	of	of	ADP
bptjm-38	61	13	abnormally	abnormally	ADV
bptjm-38	61	14	low	low	ADJ
bptjm-38	61	15	tcf4	tcf4	ADJ
bptjm-38	61	16	expression	expression	NOUN
bptjm-38	61	17	;	;	PUNCT
bptjm-38	61	18	a	a	DET
bptjm-38	61	19	complex	complex	ADJ
bptjm-38	61	20	comprising	comprising	NOUN
bptjm-38	61	21	of	of	ADP
bptjm-38	61	22	grna	grna	NOUN
bptjm-38	61	23	targeting	target	VERB
bptjm-38	61	24	promoters	promoter	NOUN
bptjm-38	61	25	of	of	ADP
bptjm-38	61	26	tcf4	tcf4	PROPN
bptjm-38	61	27	,	,	PUNCT
bptjm-38	61	28	a	a	DET
bptjm-38	61	29	transcriptional	transcriptional	ADJ
bptjm-38	61	30	activation	activation	NOUN
bptjm-38	61	31	complex	complex	ADJ
bptjm-38	61	32	(	(	PUNCT
bptjm-38	61	33	mph	mph	NOUN
bptjm-38	61	34	)	)	PUNCT
bptjm-38	61	35	and	and	CCONJ
bptjm-38	61	36	dead	dead	ADJ
bptjm-38	61	37	cas9	cas9	NOUN
bptjm-38	61	38	however	however	ADV
bptjm-38	61	39	,	,	PUNCT
bptjm-38	61	40	the	the	DET
bptjm-38	61	41	use	use	NOUN
bptjm-38	61	42	of	of	ADP
bptjm-38	61	43	two	two	NUM
bptjm-38	61	44	viral	viral	ADJ
bptjm-38	61	45	vectors	vector	NOUN
bptjm-38	61	46	created	create	VERB
bptjm-38	61	47	another	another	DET
bptjm-38	61	48	problem	problem	NOUN
bptjm-38	61	49	:	:	PUNCT
bptjm-38	61	50	a	a	DET
bptjm-38	61	51	decrease	decrease	NOUN
bptjm-38	61	52	in	in	ADP
bptjm-38	61	53	cellular	cellular	ADJ
bptjm-38	61	54	aggregation	aggregation	NOUN
bptjm-38	61	55	in	in	ADP
bptjm-38	61	56	the	the	DET
bptjm-38	61	57	brain	brain	NOUN
bptjm-38	61	58	organoids	organoid	NOUN
bptjm-38	61	59	.	.	PUNCT
bptjm-38	62	1	the	the	DET
bptjm-38	62	2	scientists	scientist	NOUN
bptjm-38	62	3	attempted	attempt	VERB
bptjm-38	62	4	another	another	DET
bptjm-38	62	5	method	method	NOUN
bptjm-38	62	6	called	call	VERB
bptjm-38	62	7	virus	virus	NOUN
bptjm-38	62	8	-	-	PUNCT
bptjm-38	62	9	mediated	mediate	VERB
bptjm-38	62	10	overexpression	overexpression	NOUN
bptjm-38	62	11	in	in	ADP
bptjm-38	62	12	which	which	PRON
bptjm-38	62	13	a	a	DET
bptjm-38	62	14	wild	wild	ADJ
bptjm-38	62	15	-	-	PUNCT
bptjm-38	62	16	type	type	NOUN
bptjm-38	62	17	copy	copy	NOUN
bptjm-38	62	18	of	of	ADP
bptjm-38	62	19	tcf4	tcf4	PROPN
bptjm-38	62	20	was	be	AUX
bptjm-38	62	21	overexpressed	overexpresse	VERB
bptjm-38	62	22	in	in	ADP
bptjm-38	62	23	hopes	hope	NOUN
bptjm-38	62	24	of	of	ADP
bptjm-38	62	25	overriding	override	VERB
bptjm-38	62	26	ectopic	ectopic	ADJ
bptjm-38	62	27	expression	expression	NOUN
bptjm-38	62	28	of	of	ADP
bptjm-38	62	29	the	the	DET
bptjm-38	62	30	mutation	mutation	NOUN
bptjm-38	62	31	.	.	PUNCT
bptjm-38	63	1	ptsh	ptsh	NOUN
bptjm-38	63	2	organoids	organoid	NOUN
bptjm-38	63	3	exposed	expose	VERB
bptjm-38	63	4	to	to	ADP
bptjm-38	63	5	overexpression	overexpression	NOUN
bptjm-38	63	6	-	-	PUNCT
bptjm-38	63	7	type	type	NOUN
bptjm-38	63	8	gene	gene	NOUN
bptjm-38	63	9	therapy	therapy	NOUN
bptjm-38	63	10	showed	show	VERB
bptjm-38	63	11	improvements	improvement	NOUN
bptjm-38	63	12	in	in	ADP
bptjm-38	63	13	two	two	NUM
bptjm-38	63	14	key	key	ADJ
bptjm-38	63	15	regions	region	NOUN
bptjm-38	63	16	that	that	PRON
bptjm-38	63	17	marked	mark	VERB
bptjm-38	63	18	the	the	DET
bptjm-38	63	19	downstream	downstream	ADJ
bptjm-38	63	20	corrected	correct	VERB
bptjm-38	63	21	function	function	NOUN
bptjm-38	63	22	of	of	ADP
bptjm-38	63	23	the	the	DET
bptjm-38	63	24	tcf4	tcf4	ADJ
bptjm-38	63	25	gene	gene	NOUN
bptjm-38	63	26	:	:	PUNCT
bptjm-38	63	27	increased	increase	VERB
bptjm-38	63	28	�	�	NOUN
bptjm-38	63	29	ring	ring	NOUN
bptjm-38	63	30	rates	rate	NOUN
bptjm-38	63	31	and	and	CCONJ
bptjm-38	63	32	number	number	NOUN
bptjm-38	63	33	of	of	ADP
bptjm-38	63	34	network	network	NOUN
bptjm-38	63	35	electrical	electrical	ADJ
bptjm-38	63	36	bursts	burst	NOUN
bptjm-38	63	37	.	.	PUNCT
bptjm-38	64	1	the	the	DET
bptjm-38	64	2	combination	combination	NOUN
bptjm-38	64	3	of	of	ADP
bptjm-38	64	4	these	these	DET
bptjm-38	64	5	two	two	NUM
bptjm-38	64	6	methods	method	NOUN
bptjm-38	64	7	,	,	PUNCT
bptjm-38	64	8	provided	provide	VERB
bptjm-38	64	9	that	that	SCONJ
bptjm-38	64	10	the	the	DET
bptjm-38	64	11	impaired	impaired	ADJ
bptjm-38	64	12	proliferation	proliferation	NOUN
bptjm-38	64	13	of	of	ADP
bptjm-38	64	14	neurons	neuron	NOUN
bptjm-38	64	15	from	from	ADP
bptjm-38	64	16	a	a	DET
bptjm-38	64	17	mutated	mutate	VERB
bptjm-38	64	18	tcf4	tcf4	NOUN
bptjm-38	64	19	can	can	AUX
bptjm-38	64	20	be	be	AUX
bptjm-38	64	21	genetically	genetically	ADV
bptjm-38	64	22	corrected	correct	VERB
bptjm-38	64	23	,	,	PUNCT
bptjm-38	64	24	could	could	AUX
bptjm-38	64	25	prove	prove	VERB
bptjm-38	64	26	to	to	PART
bptjm-38	64	27	lessen	lessen	VERB
bptjm-38	64	28	the	the	DET
bptjm-38	64	29	symptoms	symptom	NOUN
bptjm-38	64	30	of	of	ADP
bptjm-38	64	31	other	other	ADJ
bptjm-38	64	32	genetic	genetic	ADJ
bptjm-38	64	33	autism	autism	NOUN
bptjm-38	64	34	disorders	disorder	NOUN
bptjm-38	64	35	.	.	PUNCT
bptjm-38	65	1	11	11	NUM
bptjm-38	65	2	4.2	4.2	NUM
bptjm-38	65	3	reln	reln	NOUN
bptjm-38	65	4	study	study	PROPN
bptjm-38	65	5	reln	reln	NOUN
bptjm-38	65	6	is	be	AUX
bptjm-38	65	7	a	a	DET
bptjm-38	65	8	gene	gene	NOUN
bptjm-38	65	9	that	that	PRON
bptjm-38	65	10	encodes	encode	VERB
bptjm-38	65	11	for	for	ADP
bptjm-38	65	12	a	a	DET
bptjm-38	65	13	reln	reln	ADJ
bptjm-38	65	14	glycoprotein	glycoprotein	NOUN
bptjm-38	65	15	in	in	ADP
bptjm-38	65	16	the	the	DET
bptjm-38	65	17	extracellular	extracellular	ADJ
bptjm-38	65	18	matrix	matrix	NOUN
bptjm-38	65	19	of	of	ADP
bptjm-38	65	20	gabaergic	gabaergic	ADJ
bptjm-38	65	21	(	(	PUNCT
bptjm-38	65	22	gamma	gamma	NOUN
bptjm-38	65	23	-	-	PUNCT
bptjm-38	65	24	aminobutyric	aminobutyric	ADJ
bptjm-38	65	25	acid	acid	NOUN
bptjm-38	65	26	)	)	PUNCT
bptjm-38	65	27	neurons	neuron	NOUN
bptjm-38	65	28	.	.	PUNCT
bptjm-38	66	1	these	these	DET
bptjm-38	66	2	cells	cell	NOUN
bptjm-38	66	3	perform	perform	VERB
bptjm-38	66	4	important	important	ADJ
bptjm-38	66	5	functions	function	NOUN
bptjm-38	66	6	in	in	ADP
bptjm-38	66	7	neural	neural	ADJ
bptjm-38	66	8	migration	migration	NOUN
bptjm-38	66	9	and	and	CCONJ
bptjm-38	66	10	cortical	cortical	ADJ
bptjm-38	66	11	lamination	lamination	NOUN
bptjm-38	66	12	.	.	PUNCT
bptjm-38	67	1	13	13	NUM
bptjm-38	67	2	neural	neural	ADJ
bptjm-38	67	3	migration	migration	NOUN
bptjm-38	67	4	is	be	AUX
bptjm-38	67	5	an	an	DET
bptjm-38	67	6	important	important	ADJ
bptjm-38	67	7	process	process	NOUN
bptjm-38	67	8	that	that	PRON
bptjm-38	67	9	occurs	occur	VERB
bptjm-38	67	10	in	in	ADP
bptjm-38	67	11	mammalian	mammalian	ADJ
bptjm-38	67	12	nervous	nervous	ADJ
bptjm-38	67	13	system	system	NOUN
bptjm-38	67	14	development	development	NOUN
bptjm-38	67	15	.	.	PUNCT
bptjm-38	68	1	14	14	NUM
bptjm-38	68	2	cortical	cortical	ADJ
bptjm-38	68	3	lamination	lamination	NOUN
bptjm-38	68	4	is	be	AUX
bptjm-38	68	5	the	the	DET
bptjm-38	68	6	layering	layering	NOUN
bptjm-38	68	7	of	of	ADP
bptjm-38	68	8	cells	cell	NOUN
bptjm-38	68	9	of	of	ADP
bptjm-38	68	10	berkeley	berkeley	PROPN
bptjm-38	68	11	pharma	pharma	PROPN
bptjm-38	68	12	tech	tech	NOUN
bptjm-38	68	13	journal	journal	NOUN
bptjm-38	68	14	of	of	ADP
bptjm-38	68	15	medicine	medicine	NOUN
bptjm-38	68	16	|	|	ADV
bptjm-38	68	17	15	15	NUM
bptjm-38	68	18	the	the	DET
bptjm-38	68	19	outer	outer	ADJ
bptjm-38	68	20	regions	region	NOUN
bptjm-38	68	21	of	of	ADP
bptjm-38	68	22	the	the	DET
bptjm-38	68	23	brain	brain	NOUN
bptjm-38	68	24	’s	’s	PART
bptjm-38	68	25	cerebrum	cerebrum	NOUN
bptjm-38	68	26	,	,	PUNCT
bptjm-38	68	27	helping	help	VERB
bptjm-38	68	28	to	to	PART
bptjm-38	68	29	maintain	maintain	VERB
bptjm-38	68	30	neuronal	neuronal	ADJ
bptjm-38	68	31	cytoskeletal	cytoskeletal	ADJ
bptjm-38	68	32	stability	stability	NOUN
bptjm-38	68	33	.	.	PUNCT
bptjm-38	69	1	reduced	reduce	VERB
bptjm-38	69	2	reln	reln	NOUN
bptjm-38	69	3	levels	level	NOUN
bptjm-38	69	4	have	have	AUX
bptjm-38	69	5	been	be	AUX
bptjm-38	69	6	shown	show	VERB
bptjm-38	69	7	to	to	PART
bptjm-38	69	8	be	be	AUX
bptjm-38	69	9	associated	associate	VERB
bptjm-38	69	10	with	with	ADP
bptjm-38	69	11	di	di	NOUN
bptjm-38	69	12	�	�	PROPN
bptjm-38	69	13	erent	erent	NOUN
bptjm-38	69	14	psychological	psychological	ADJ
bptjm-38	69	15	disorders	disorder	NOUN
bptjm-38	69	16	including	include	VERB
bptjm-38	69	17	bipolar	bipolar	ADJ
bptjm-38	69	18	disorder	disorder	NOUN
bptjm-38	69	19	,	,	PUNCT
bptjm-38	69	20	alzheimer	alzheimer	PROPN
bptjm-38	69	21	's	's	PART
bptjm-38	69	22	disease	disease	NOUN
bptjm-38	69	23	,	,	PUNCT
bptjm-38	69	24	and	and	CCONJ
bptjm-38	69	25	autism	autism	NOUN
bptjm-38	69	26	spectrum	spectrum	NOUN
bptjm-38	69	27	disorder	disorder	NOUN
bptjm-38	69	28	.	.	PUNCT
bptjm-38	70	1	studies	study	NOUN
bptjm-38	70	2	have	have	AUX
bptjm-38	70	3	shown	show	VERB
bptjm-38	70	4	signi	signi	ADJ
bptjm-38	70	5	�	�	NOUN
bptjm-38	70	6	cantly	cantly	ADV
bptjm-38	70	7	lower	low	ADJ
bptjm-38	70	8	levels	level	NOUN
bptjm-38	70	9	of	of	ADP
bptjm-38	70	10	reln	reln	NOUN
bptjm-38	70	11	in	in	ADP
bptjm-38	70	12	asd	asd	PROPN
bptjm-38	70	13	patient	patient	NOUN
bptjm-38	70	14	’s	’s	PART
bptjm-38	70	15	superior	superior	ADJ
bptjm-38	70	16	frontal	frontal	ADJ
bptjm-38	70	17	cortex	cortex	NOUN
bptjm-38	70	18	,	,	PUNCT
bptjm-38	70	19	parietal	parietal	ADJ
bptjm-38	70	20	cortex	cortex	NOUN
bptjm-38	70	21	,	,	PUNCT
bptjm-38	70	22	cerebella	cerebellum	NOUN
bptjm-38	70	23	and	and	CCONJ
bptjm-38	70	24	plasma	plasma	NOUN
bptjm-38	70	25	.	.	PUNCT
bptjm-38	71	1	this	this	PRON
bptjm-38	71	2	could	could	AUX
bptjm-38	71	3	potentially	potentially	ADV
bptjm-38	71	4	be	be	AUX
bptjm-38	71	5	because	because	SCONJ
bptjm-38	71	6	of	of	ADP
bptjm-38	71	7	reln	reln	ADJ
bptjm-38	71	8	promoter	promoter	NOUN
bptjm-38	71	9	hypermethylation	hypermethylation	NOUN
bptjm-38	71	10	that	that	PRON
bptjm-38	71	11	occurs	occur	VERB
bptjm-38	71	12	in	in	ADP
bptjm-38	71	13	gabaergic	gabaergic	ADJ
bptjm-38	71	14	neurons	neuron	NOUN
bptjm-38	71	15	,	,	PUNCT
bptjm-38	71	16	as	as	SCONJ
bptjm-38	71	17	seen	see	VERB
bptjm-38	71	18	in	in	ADP
bptjm-38	71	19	seizure	seizure	NOUN
bptjm-38	71	20	disorder	disorder	NOUN
bptjm-38	71	21	patients	patient	NOUN
bptjm-38	71	22	.	.	PUNCT
bptjm-38	72	1	13	13	NUM
bptjm-38	72	2	in	in	ADP
bptjm-38	72	3	addition	addition	NOUN
bptjm-38	72	4	,	,	PUNCT
bptjm-38	72	5	sex	sex	NOUN
bptjm-38	72	6	hormones	hormone	NOUN
bptjm-38	72	7	can	can	AUX
bptjm-38	72	8	also	also	ADV
bptjm-38	72	9	play	play	VERB
bptjm-38	72	10	a	a	DET
bptjm-38	72	11	role	role	NOUN
bptjm-38	72	12	in	in	ADP
bptjm-38	72	13	methylation	methylation	NOUN
bptjm-38	72	14	of	of	ADP
bptjm-38	72	15	the	the	DET
bptjm-38	72	16	reln	reln	NOUN
bptjm-38	72	17	promoter	promoter	NOUN
bptjm-38	72	18	,	,	PUNCT
bptjm-38	72	19	which	which	PRON
bptjm-38	72	20	has	have	AUX
bptjm-38	72	21	shown	show	VERB
bptjm-38	72	22	to	to	PART
bptjm-38	72	23	increase	increase	VERB
bptjm-38	72	24	asd	asd	ADJ
bptjm-38	72	25	-	-	PUNCT
bptjm-38	72	26	associated	associate	VERB
bptjm-38	72	27	behaviors	behavior	NOUN
bptjm-38	72	28	.	.	PUNCT
bptjm-38	73	1	after	after	ADP
bptjm-38	73	2	postmortem	postmortem	NOUN
bptjm-38	73	3	cerebellar	cerebellar	PROPN
bptjm-38	73	4	studies	study	NOUN
bptjm-38	73	5	of	of	ADP
bptjm-38	73	6	asd	asd	PROPN
bptjm-38	73	7	patients	patient	NOUN
bptjm-38	73	8	,	,	PUNCT
bptjm-38	73	9	it	it	PRON
bptjm-38	73	10	was	be	AUX
bptjm-38	73	11	found	find	VERB
bptjm-38	73	12	that	that	SCONJ
bptjm-38	73	13	lower	low	ADJ
bptjm-38	73	14	reln	reln	PROPN
bptjm-38	73	15	mrna	mrna	PROPN
bptjm-38	73	16	levels	level	NOUN
bptjm-38	73	17	are	be	AUX
bptjm-38	73	18	associated	associate	VERB
bptjm-38	73	19	with	with	ADP
bptjm-38	73	20	higher	high	ADJ
bptjm-38	73	21	mecp2	mecp2	NOUN
bptjm-38	73	22	(	(	PUNCT
bptjm-38	73	23	another	another	DET
bptjm-38	73	24	essential	essential	ADJ
bptjm-38	73	25	protein	protein	NOUN
bptjm-38	73	26	for	for	ADP
bptjm-38	73	27	nerve	nerve	NOUN
bptjm-38	73	28	cells	cell	NOUN
bptjm-38	73	29	)	)	PUNCT
bptjm-38	73	30	binding	bind	VERB
bptjm-38	73	31	,	,	PUNCT
bptjm-38	73	32	increasing	increase	VERB
bptjm-38	73	33	gene	gene	NOUN
bptjm-38	73	34	regulator	regulator	NOUN
bptjm-38	73	35	5	5	NUM
bptjm-38	73	36	-	-	PUNCT
bptjm-38	73	37	hmc	hmc	NOUN
bptjm-38	73	38	at	at	ADP
bptjm-38	73	39	the	the	DET
bptjm-38	73	40	reln	reln	ADJ
bptjm-38	73	41	promoter	promoter	NOUN
bptjm-38	73	42	and	and	CCONJ
bptjm-38	73	43	in	in	ADP
bptjm-38	73	44	turn	turn	NOUN
bptjm-38	73	45	decreasing	decrease	VERB
bptjm-38	73	46	transcription	transcription	NOUN
bptjm-38	73	47	and	and	CCONJ
bptjm-38	73	48	protein	protein	NOUN
bptjm-38	73	49	levels	level	NOUN
bptjm-38	73	50	.	.	PUNCT
bptjm-38	74	1	such	such	ADJ
bptjm-38	74	2	reln	reln	ADJ
bptjm-38	74	3	mutations	mutation	NOUN
bptjm-38	74	4	that	that	PRON
bptjm-38	74	5	cause	cause	VERB
bptjm-38	74	6	disruptions	disruption	NOUN
bptjm-38	74	7	in	in	ADP
bptjm-38	74	8	signaling	signal	VERB
bptjm-38	74	9	pathways	pathway	NOUN
bptjm-38	74	10	are	be	AUX
bptjm-38	74	11	connected	connect	VERB
bptjm-38	74	12	to	to	ADP
bptjm-38	74	13	asd	asd	NOUN
bptjm-38	74	14	disorders	disorder	NOUN
bptjm-38	74	15	.	.	PUNCT
bptjm-38	75	1	one	one	NUM
bptjm-38	75	2	example	example	NOUN
bptjm-38	75	3	is	be	AUX
bptjm-38	75	4	the	the	DET
bptjm-38	75	5	loss	loss	NOUN
bptjm-38	75	6	of	of	ADP
bptjm-38	75	7	purkinje	purkinje	PROPN
bptjm-38	75	8	cells	cell	NOUN
bptjm-38	75	9	,	,	PUNCT
bptjm-38	75	10	regulated	regulate	VERB
bptjm-38	75	11	by	by	ADP
bptjm-38	75	12	reln	reln	NOUN
bptjm-38	75	13	,	,	PUNCT
bptjm-38	75	14	which	which	PRON
bptjm-38	75	15	increases	increase	VERB
bptjm-38	75	16	the	the	DET
bptjm-38	75	17	risk	risk	NOUN
bptjm-38	75	18	of	of	ADP
bptjm-38	75	19	cognitive	cognitive	ADJ
bptjm-38	75	20	delay	delay	NOUN
bptjm-38	75	21	and	and	CCONJ
bptjm-38	75	22	epilepsy	epilepsy	NOUN
bptjm-38	75	23	.	.	PUNCT
bptjm-38	76	1	this	this	PRON
bptjm-38	76	2	is	be	AUX
bptjm-38	76	3	a	a	DET
bptjm-38	76	4	phenomenon	phenomenon	NOUN
bptjm-38	76	5	also	also	ADV
bptjm-38	76	6	seen	see	VERB
bptjm-38	76	7	in	in	ADP
bptjm-38	76	8	asd	asd	PROPN
bptjm-38	76	9	patients	patient	NOUN
bptjm-38	76	10	.	.	PUNCT
bptjm-38	77	1	15	15	NUM
bptjm-38	78	1	investigating	investigate	VERB
bptjm-38	78	2	the	the	DET
bptjm-38	78	3	role	role	NOUN
bptjm-38	78	4	of	of	ADP
bptjm-38	78	5	reln	reln	NOUN
bptjm-38	78	6	on	on	ADP
bptjm-38	78	7	neuronal	neuronal	ADJ
bptjm-38	78	8	signaling	signal	VERB
bptjm-38	78	9	and	and	CCONJ
bptjm-38	78	10	asd	asd	PROPN
bptjm-38	78	11	development	development	NOUN
bptjm-38	78	12	can	can	AUX
bptjm-38	78	13	produce	produce	VERB
bptjm-38	78	14	promising	promising	ADJ
bptjm-38	78	15	leads	lead	NOUN
bptjm-38	78	16	for	for	ADP
bptjm-38	78	17	potential	potential	ADJ
bptjm-38	78	18	treatments	treatment	NOUN
bptjm-38	78	19	of	of	ADP
bptjm-38	78	20	asd	asd	NOUN
bptjm-38	78	21	.	.	PUNCT
bptjm-38	79	1	increasing	increase	VERB
bptjm-38	79	2	levels	level	NOUN
bptjm-38	79	3	of	of	ADP
bptjm-38	79	4	reln	reln	ADJ
bptjm-38	79	5	protein	protein	NOUN
bptjm-38	79	6	can	can	AUX
bptjm-38	79	7	alleviate	alleviate	VERB
bptjm-38	79	8	behavioral	behavioral	ADJ
bptjm-38	79	9	symptoms	symptom	NOUN
bptjm-38	79	10	of	of	ADP
bptjm-38	79	11	reln	reln	NOUN
bptjm-38	79	12	that	that	SCONJ
bptjm-38	79	13	asd	asd	PROPN
bptjm-38	79	14	patients	patient	NOUN
bptjm-38	79	15	also	also	ADV
bptjm-38	79	16	experience	experience	VERB
bptjm-38	79	17	.	.	PUNCT
bptjm-38	80	1	however	however	ADV
bptjm-38	80	2	,	,	PUNCT
bptjm-38	80	3	although	although	SCONJ
bptjm-38	80	4	there	there	PRON
bptjm-38	80	5	is	be	VERB
bptjm-38	80	6	much	much	ADJ
bptjm-38	80	7	evidence	evidence	NOUN
bptjm-38	80	8	for	for	ADP
bptjm-38	80	9	reln	reln	PROPN
bptjm-38	80	10	’s	’s	X
bptjm-38	80	11	in	in	ADP
bptjm-38	80	12	�	�	NOUN
bptjm-38	80	13	uence	uence	NOUN
bptjm-38	80	14	on	on	ADP
bptjm-38	80	15	asd	asd	PROPN
bptjm-38	80	16	,	,	PUNCT
bptjm-38	80	17	it	it	PRON
bptjm-38	80	18	is	be	AUX
bptjm-38	80	19	not	not	PART
bptjm-38	80	20	the	the	DET
bptjm-38	80	21	sole	sole	ADJ
bptjm-38	80	22	factor	factor	NOUN
bptjm-38	80	23	of	of	ADP
bptjm-38	80	24	asd	asd	PROPN
bptjm-38	80	25	development	development	NOUN
bptjm-38	80	26	.	.	PUNCT
bptjm-38	81	1	for	for	ADP
bptjm-38	81	2	the	the	DET
bptjm-38	81	3	diagnosis	diagnosis	NOUN
bptjm-38	81	4	of	of	ADP
bptjm-38	81	5	asd	asd	NOUN
bptjm-38	81	6	,	,	PUNCT
bptjm-38	81	7	there	there	PRON
bptjm-38	81	8	are	be	VERB
bptjm-38	81	9	usually	usually	ADV
bptjm-38	81	10	secondary	secondary	ADJ
bptjm-38	81	11	genetic	genetic	ADJ
bptjm-38	81	12	or	or	CCONJ
bptjm-38	81	13	environmental	environmental	ADJ
bptjm-38	81	14	factors	factor	NOUN
bptjm-38	81	15	that	that	PRON
bptjm-38	81	16	contribute	contribute	VERB
bptjm-38	81	17	to	to	ADP
bptjm-38	81	18	the	the	DET
bptjm-38	81	19	disorder	disorder	NOUN
bptjm-38	81	20	’s	’s	PART
bptjm-38	81	21	development	development	NOUN
bptjm-38	81	22	.	.	PUNCT
bptjm-38	82	1	16	16	NUM
bptjm-38	82	2	4.3	4.3	NUM
bptjm-38	82	3	mecp2	mecp2	NOUN
bptjm-38	82	4	gene	gene	NOUN
bptjm-38	82	5	study	study	NOUN
bptjm-38	82	6	many	many	ADJ
bptjm-38	82	7	studies	study	NOUN
bptjm-38	82	8	have	have	AUX
bptjm-38	82	9	shown	show	VERB
bptjm-38	82	10	mecp2	mecp2	NOUN
bptjm-38	82	11	protein	protein	NOUN
bptjm-38	82	12	’s	’s	PART
bptjm-38	82	13	role	role	NOUN
bptjm-38	82	14	in	in	ADP
bptjm-38	82	15	brain	brain	NOUN
bptjm-38	82	16	development	development	NOUN
bptjm-38	82	17	and	and	CCONJ
bptjm-38	82	18	regulation	regulation	NOUN
bptjm-38	82	19	,	,	PUNCT
bptjm-38	82	20	such	such	ADJ
bptjm-38	82	21	as	as	ADP
bptjm-38	82	22	expression	expression	NOUN
bptjm-38	82	23	of	of	ADP
bptjm-38	82	24	the	the	DET
bptjm-38	82	25	brain	brain	NOUN
bptjm-38	82	26	-	-	PUNCT
bptjm-38	82	27	derived	derive	VERB
bptjm-38	82	28	neurotrophic	neurotrophic	ADJ
bptjm-38	82	29	factor	factor	NOUN
bptjm-38	82	30	(	(	PUNCT
bptjm-38	82	31	bdnf	bdnf	PROPN
bptjm-38	82	32	)	)	PUNCT
bptjm-38	82	33	gene	gene	NOUN
bptjm-38	82	34	and	and	CCONJ
bptjm-38	82	35	regulation	regulation	NOUN
bptjm-38	82	36	of	of	ADP
bptjm-38	82	37	synaptic	synaptic	ADJ
bptjm-38	82	38	homeostatic	homeostatic	ADJ
bptjm-38	82	39	plasticity	plasticity	NOUN
bptjm-38	82	40	.	.	PUNCT
bptjm-38	83	1	mecp2	mecp2	NOUN
bptjm-38	83	2	is	be	AUX
bptjm-38	83	3	a	a	DET
bptjm-38	83	4	part	part	NOUN
bptjm-38	83	5	of	of	ADP
bptjm-38	83	6	the	the	DET
bptjm-38	83	7	methyl	methyl	NOUN
bptjm-38	83	8	-	-	PUNCT
bptjm-38	83	9	cpg	cpg	NOUN
bptjm-38	83	10	-	-	PUNCT
bptjm-38	83	11	binding	bind	VERB
bptjm-38	83	12	protein	protein	NOUN
bptjm-38	83	13	family	family	NOUN
bptjm-38	83	14	which	which	PRON
bptjm-38	83	15	regulates	regulate	VERB
bptjm-38	83	16	gene	gene	NOUN
bptjm-38	83	17	expression	expression	NOUN
bptjm-38	83	18	by	by	ADP
bptjm-38	83	19	modifying	modify	VERB
bptjm-38	83	20	chromatin	chromatin	NOUN
bptjm-38	83	21	,	,	PUNCT
bptjm-38	83	22	a	a	DET
bptjm-38	83	23	protein	protein	NOUN
bptjm-38	83	24	complex	complex	NOUN
bptjm-38	83	25	of	of	ADP
bptjm-38	83	26	dna	dna	PROPN
bptjm-38	83	27	and	and	CCONJ
bptjm-38	83	28	histone	histone	NOUN
bptjm-38	83	29	proteins	protein	NOUN
bptjm-38	83	30	that	that	PRON
bptjm-38	83	31	package	package	VERB
bptjm-38	83	32	dna	dna	NOUN
bptjm-38	83	33	in	in	ADP
bptjm-38	83	34	chromosomes	chromosome	NOUN
bptjm-38	83	35	.	.	PUNCT
bptjm-38	84	1	mecp2	mecp2	NOUN
bptjm-38	84	2	performs	perform	VERB
bptjm-38	84	3	regulation	regulation	NOUN
bptjm-38	84	4	of	of	ADP
bptjm-38	84	5	dna	dna	PROPN
bptjm-38	84	6	methylation	methylation	NOUN
bptjm-38	84	7	via	via	ADP
bptjm-38	84	8	recruitment	recruitment	NOUN
bptjm-38	84	9	of	of	ADP
bptjm-38	84	10	histone	histone	NOUN
bptjm-38	84	11	deacetylases	deacetylase	NOUN
bptjm-38	84	12	.	.	PUNCT
bptjm-38	85	1	17	17	NUM
bptjm-38	85	2	,	,	PUNCT
bptjm-38	85	3	18	18	NUM
bptjm-38	85	4	berkeley	berkeley	PROPN
bptjm-38	85	5	pharma	pharma	PROPN
bptjm-38	85	6	tech	tech	NOUN
bptjm-38	85	7	journal	journal	NOUN
bptjm-38	85	8	of	of	ADP
bptjm-38	85	9	medicine	medicine	NOUN
bptjm-38	85	10	|	|	ADV
bptjm-38	85	11	16	16	NUM
bptjm-38	85	12	figure	figure	NOUN
bptjm-38	85	13	2	2	NUM
bptjm-38	85	14	:	:	PUNCT
bptjm-38	85	15	mecp2	mecp2	NOUN
bptjm-38	85	16	protein	protein	NOUN
bptjm-38	85	17	structure	structure	NOUN
bptjm-38	85	18	figure	figure	NOUN
bptjm-38	85	19	3	3	NUM
bptjm-38	85	20	:	:	PUNCT
bptjm-38	85	21	the	the	DET
bptjm-38	85	22	mecp2	mecp2	NOUN
bptjm-38	85	23	gene	gene	NOUN
bptjm-38	85	24	mecp2	mecp2	NOUN
bptjm-38	85	25	is	be	AUX
bptjm-38	85	26	found	find	VERB
bptjm-38	85	27	in	in	ADP
bptjm-38	85	28	high	high	ADJ
bptjm-38	85	29	concentrations	concentration	NOUN
bptjm-38	85	30	in	in	ADP
bptjm-38	85	31	neurons	neuron	NOUN
bptjm-38	85	32	.	.	PUNCT
bptjm-38	86	1	the	the	DET
bptjm-38	86	2	gene	gene	NOUN
bptjm-38	86	3	locus	locus	NOUN
bptjm-38	86	4	is	be	AUX
bptjm-38	86	5	located	locate	VERB
bptjm-38	86	6	on	on	ADP
bptjm-38	86	7	the	the	DET
bptjm-38	86	8	long	long	ADJ
bptjm-38	86	9	(	(	PUNCT
bptjm-38	86	10	q	q	NOUN
bptjm-38	86	11	)	)	PUNCT
bptjm-38	86	12	arm	arm	NOUN
bptjm-38	86	13	of	of	ADP
bptjm-38	86	14	the	the	DET
bptjm-38	86	15	x	x	PUNCT
bptjm-38	86	16	chromosome	chromosome	NOUN
bptjm-38	86	17	in	in	ADP
bptjm-38	86	18	band	band	NOUN
bptjm-38	86	19	28	28	NUM
bptjm-38	86	20	(	(	PUNCT
bptjm-38	86	21	“	"	PUNCT
bptjm-38	86	22	xq28	xq28	PROPN
bptjm-38	86	23	”	"	PUNCT
bptjm-38	86	24	)	)	PUNCT
bptjm-38	86	25	.	.	PUNCT
bptjm-38	87	1	mecp2	mecp2	NOUN
bptjm-38	87	2	's	's	PART
bptjm-38	87	3	main	main	ADJ
bptjm-38	87	4	role	role	NOUN
bptjm-38	87	5	is	be	AUX
bptjm-38	87	6	"	"	PUNCT
bptjm-38	87	7	repressing	repress	VERB
bptjm-38	87	8	"	"	PUNCT
bptjm-38	87	9	or	or	CCONJ
bptjm-38	87	10	"	"	PUNCT
bptjm-38	87	11	silencing	silence	VERB
bptjm-38	87	12	"	"	PUNCT
bptjm-38	87	13	other	other	ADJ
bptjm-38	87	14	genes	gene	NOUN
bptjm-38	87	15	,	,	PUNCT
bptjm-38	87	16	preventing	prevent	VERB
bptjm-38	87	17	transcription	transcription	NOUN
bptjm-38	87	18	and	and	CCONJ
bptjm-38	87	19	translation	translation	NOUN
bptjm-38	87	20	when	when	SCONJ
bptjm-38	87	21	they	they	PRON
bptjm-38	87	22	are	be	AUX
bptjm-38	87	23	not	not	PART
bptjm-38	87	24	needed	need	VERB
bptjm-38	87	25	.	.	PUNCT
bptjm-38	88	1	recent	recent	ADJ
bptjm-38	88	2	studies	study	NOUN
bptjm-38	88	3	have	have	AUX
bptjm-38	88	4	suggested	suggest	VERB
bptjm-38	88	5	that	that	DET
bptjm-38	88	6	mecp2	mecp2	NOUN
bptjm-38	88	7	can	can	AUX
bptjm-38	88	8	act	act	VERB
bptjm-38	88	9	as	as	ADP
bptjm-38	88	10	an	an	DET
bptjm-38	88	11	activator	activator	NOUN
bptjm-38	88	12	,	,	PUNCT
bptjm-38	88	13	but	but	CCONJ
bptjm-38	88	14	this	this	PRON
bptjm-38	88	15	is	be	AUX
bptjm-38	88	16	still	still	ADV
bptjm-38	88	17	a	a	DET
bptjm-38	88	18	new	new	ADJ
bptjm-38	88	19	and	and	CCONJ
bptjm-38	88	20	controversial	controversial	ADJ
bptjm-38	88	21	theory	theory	NOUN
bptjm-38	88	22	.	.	PUNCT
bptjm-38	89	1	mecp2	mecp2	NOUN
bptjm-38	89	2	represses	repress	VERB
bptjm-38	89	3	gene	gene	NOUN
bptjm-38	89	4	expression	expression	NOUN
bptjm-38	89	5	by	by	ADP
bptjm-38	89	6	recognizing	recognize	VERB
bptjm-38	89	7	and	and	CCONJ
bptjm-38	89	8	binding	bind	VERB
bptjm-38	89	9	to	to	ADP
bptjm-38	89	10	methylated	methylate	VERB
bptjm-38	89	11	cytosine	cytosine	NOUN
bptjm-38	89	12	residues	residue	NOUN
bptjm-38	89	13	in	in	ADP
bptjm-38	89	14	dna	dna	PROPN
bptjm-38	89	15	called	call	VERB
bptjm-38	89	16	5mecyt	5mecyt	PROPN
bptjm-38	89	17	;	;	PUNCT
bptjm-38	89	18	regions	region	NOUN
bptjm-38	89	19	enriched	enrich	VERB
bptjm-38	89	20	with	with	ADP
bptjm-38	89	21	a	a	DET
bptjm-38	89	22	/	/	SYM
bptjm-38	89	23	t	t	PROPN
bptjm-38	89	24	neighbor	neighbor	NOUN
bptjm-38	89	25	bases	basis	NOUN
bptjm-38	89	26	.	.	PUNCT
bptjm-38	90	1	mecp2	mecp2	NOUN
bptjm-38	90	2	is	be	AUX
bptjm-38	90	3	also	also	ADV
bptjm-38	90	4	able	able	ADJ
bptjm-38	90	5	to	to	PART
bptjm-38	90	6	bind	bind	VERB
bptjm-38	90	7	to	to	ADP
bptjm-38	90	8	hydroxymethylated	hydroxymethylate	VERB
bptjm-38	90	9	dna	dna	PROPN
bptjm-38	90	10	called	call	VERB
bptjm-38	90	11	5	5	NUM
bptjm-38	90	12	-	-	PUNCT
bptjm-38	90	13	hydroxy	hydroxy	NOUN
bptjm-38	90	14	methylated	methylate	VERB
bptjm-38	90	15	cytosine	cytosine	NOUN
bptjm-38	90	16	.	.	PUNCT
bptjm-38	91	1	18	18	NUM
bptjm-38	91	2	berkeley	berkeley	PROPN
bptjm-38	91	3	pharma	pharma	PROPN
bptjm-38	91	4	tech	tech	NOUN
bptjm-38	91	5	journal	journal	NOUN
bptjm-38	91	6	of	of	ADP
bptjm-38	91	7	medicine	medicine	NOUN
bptjm-38	91	8	|	|	ADV
bptjm-38	91	9	17	17	NUM
bptjm-38	91	10	figure	figure	NOUN
bptjm-38	91	11	4	4	NUM
bptjm-38	91	12	:	:	PUNCT
bptjm-38	91	13	the	the	DET
bptjm-38	91	14	varied	varied	ADJ
bptjm-38	91	15	molecular	molecular	ADJ
bptjm-38	91	16	functions	function	NOUN
bptjm-38	91	17	of	of	ADP
bptjm-38	91	18	mecp2	mecp2	NOUN
bptjm-38	91	19	protein	protein	NOUN
bptjm-38	91	20	the	the	DET
bptjm-38	91	21	relationship	relationship	NOUN
bptjm-38	91	22	between	between	ADP
bptjm-38	91	23	autism	autism	NOUN
bptjm-38	91	24	and	and	CCONJ
bptjm-38	91	25	mecp2	mecp2	NOUN
bptjm-38	91	26	mutations	mutation	NOUN
bptjm-38	91	27	that	that	PRON
bptjm-38	91	28	alter	alter	VERB
bptjm-38	91	29	typical	typical	ADJ
bptjm-38	91	30	mecp2	mecp2	NOUN
bptjm-38	91	31	function	function	NOUN
bptjm-38	91	32	will	will	AUX
bptjm-38	91	33	lead	lead	VERB
bptjm-38	91	34	to	to	ADP
bptjm-38	91	35	severe	severe	ADJ
bptjm-38	91	36	neurodevelopmental	neurodevelopmental	ADJ
bptjm-38	91	37	disorders	disorder	NOUN
bptjm-38	91	38	such	such	ADJ
bptjm-38	91	39	as	as	ADP
bptjm-38	91	40	rett	rett	PROPN
bptjm-38	91	41	syndrome	syndrome	PROPN
bptjm-38	91	42	(	(	PUNCT
bptjm-38	91	43	rtt	rtt	PROPN
bptjm-38	91	44	)	)	PUNCT
bptjm-38	91	45	and	and	CCONJ
bptjm-38	91	46	asd	asd	NOUN
bptjm-38	91	47	.	.	PUNCT
bptjm-38	92	1	more	more	ADJ
bptjm-38	92	2	than	than	ADP
bptjm-38	92	3	95	95	NUM
bptjm-38	92	4	%	%	NOUN
bptjm-38	92	5	rtt	rtt	NOUN
bptjm-38	92	6	patients	patient	NOUN
bptjm-38	92	7	carry	carry	VERB
bptjm-38	92	8	mutant	mutant	ADJ
bptjm-38	92	9	mecp2	mecp2	NOUN
bptjm-38	92	10	,	,	PUNCT
bptjm-38	92	11	and	and	CCONJ
bptjm-38	92	12	some	some	DET
bptjm-38	92	13	mecp2	mecp2	NOUN
bptjm-38	92	14	mutations	mutation	NOUN
bptjm-38	92	15	have	have	AUX
bptjm-38	92	16	been	be	AUX
bptjm-38	92	17	reported	report	VERB
bptjm-38	92	18	in	in	ADP
bptjm-38	92	19	asd	asd	PROPN
bptjm-38	92	20	patients	patient	NOUN
bptjm-38	92	21	.	.	PUNCT
bptjm-38	93	1	asd	asd	PROPN
bptjm-38	93	2	and	and	CCONJ
bptjm-38	93	3	rtt	rtt	NOUN
bptjm-38	93	4	overlap	overlap	NOUN
bptjm-38	93	5	in	in	ADP
bptjm-38	93	6	certain	certain	ADJ
bptjm-38	93	7	phenotypes	phenotype	NOUN
bptjm-38	93	8	,	,	PUNCT
bptjm-38	93	9	including	include	VERB
bptjm-38	93	10	stereotypical	stereotypical	ADJ
bptjm-38	93	11	body	body	NOUN
bptjm-38	93	12	movements	movement	NOUN
bptjm-38	93	13	,	,	PUNCT
bptjm-38	93	14	social	social	ADJ
bptjm-38	93	15	avoidance	avoidance	NOUN
bptjm-38	93	16	,	,	PUNCT
bptjm-38	93	17	and	and	CCONJ
bptjm-38	93	18	anxiety	anxiety	NOUN
bptjm-38	93	19	.	.	PUNCT
bptjm-38	94	1	17	17	NUM
bptjm-38	94	2	,	,	PUNCT
bptjm-38	94	3	18	18	NUM
bptjm-38	94	4	in	in	ADP
bptjm-38	94	5	a	a	DET
bptjm-38	94	6	study	study	NOUN
bptjm-38	94	7	conducted	conduct	VERB
bptjm-38	94	8	by	by	ADP
bptjm-38	94	9	zhu	zhu	PROPN
bptjm-38	94	10	wen	wen	PROPN
bptjm-38	94	11	at	at	ADP
bptjm-38	94	12	school	school	NOUN
bptjm-38	94	13	of	of	ADP
bptjm-38	94	14	life	life	NOUN
bptjm-38	94	15	sciences	science	NOUN
bptjm-38	94	16	in	in	ADP
bptjm-38	94	17	peking	peking	PROPN
bptjm-38	94	18	university	university	NOUN
bptjm-38	94	19	,	,	PUNCT
bptjm-38	94	20	whole	whole	ADJ
bptjm-38	94	21	-	-	PUNCT
bptjm-38	94	22	exome	exome	NOUN
bptjm-38	94	23	sequencing	sequencing	NOUN
bptjm-38	94	24	(	(	PUNCT
bptjm-38	94	25	wes	wes	PROPN
bptjm-38	94	26	)	)	PUNCT
bptjm-38	94	27	was	be	AUX
bptjm-38	94	28	performed	perform	VERB
bptjm-38	94	29	on	on	ADP
bptjm-38	94	30	120	120	NUM
bptjm-38	94	31	asd	asd	NOUN
bptjm-38	94	32	cases	case	NOUN
bptjm-38	94	33	.	.	PUNCT
bptjm-38	95	1	this	this	DET
bptjm-38	95	2	experiment	experiment	NOUN
bptjm-38	95	3	was	be	AUX
bptjm-38	95	4	able	able	ADJ
bptjm-38	95	5	to	to	PART
bptjm-38	95	6	identify	identify	VERB
bptjm-38	95	7	three	three	NUM
bptjm-38	95	8	mutations	mutation	NOUN
bptjm-38	95	9	in	in	ADP
bptjm-38	95	10	the	the	DET
bptjm-38	95	11	coding	code	VERB
bptjm-38	95	12	regions	region	NOUN
bptjm-38	95	13	of	of	ADP
bptjm-38	95	14	the	the	DET
bptjm-38	95	15	mecp2	mecp2	NOUN
bptjm-38	95	16	gene	gene	NOUN
bptjm-38	95	17	.	.	PUNCT
bptjm-38	96	1	they	they	PRON
bptjm-38	96	2	found	find	VERB
bptjm-38	96	3	that	that	SCONJ
bptjm-38	96	4	the	the	DET
bptjm-38	96	5	mecp2	mecp2	NOUN
bptjm-38	96	6	gene	gene	NOUN
bptjm-38	96	7	was	be	AUX
bptjm-38	96	8	linked	link	VERB
bptjm-38	96	9	with	with	ADP
bptjm-38	96	10	a	a	DET
bptjm-38	96	11	host	host	NOUN
bptjm-38	96	12	of	of	ADP
bptjm-38	96	13	neuropsychiatric	neuropsychiatric	ADJ
bptjm-38	96	14	disorders	disorder	NOUN
bptjm-38	96	15	and	and	CCONJ
bptjm-38	96	16	neurological	neurological	ADJ
bptjm-38	96	17	phenotypes	phenotype	NOUN
bptjm-38	96	18	.	.	PUNCT
bptjm-38	97	1	18	18	NUM
bptjm-38	97	2	5.1	5.1	NUM
bptjm-38	97	3	methods	method	NOUN
bptjm-38	97	4	:	:	PUNCT
bptjm-38	97	5	120	120	NUM
bptjm-38	97	6	han	han	PROPN
bptjm-38	97	7	chinese	chinese	ADJ
bptjm-38	97	8	families	family	NOUN
bptjm-38	97	9	were	be	AUX
bptjm-38	97	10	selected	select	VERB
bptjm-38	97	11	with	with	ADP
bptjm-38	97	12	probands	proband	NOUN
bptjm-38	97	13	diagnosed	diagnose	VERB
bptjm-38	97	14	with	with	ADP
bptjm-38	97	15	asd	asd	NOUN
bptjm-38	97	16	from	from	ADP
bptjm-38	97	17	2013	2013	NUM
bptjm-38	97	18	-	-	SYM
bptjm-38	97	19	2015	2015	NUM
bptjm-38	97	20	in	in	ADP
bptjm-38	97	21	the	the	DET
bptjm-38	97	22	department	department	NOUN
bptjm-38	97	23	of	of	ADP
bptjm-38	97	24	child	child	NOUN
bptjm-38	97	25	and	and	CCONJ
bptjm-38	97	26	adolescent	adolescent	ADJ
bptjm-38	97	27	psychiatry	psychiatry	NOUN
bptjm-38	97	28	in	in	ADP
bptjm-38	97	29	shanghai	shanghai	PROPN
bptjm-38	97	30	mental	mental	PROPN
bptjm-38	97	31	health	health	PROPN
bptjm-38	97	32	center	center	NOUN
bptjm-38	97	33	.	.	PUNCT
bptjm-38	98	1	the	the	DET
bptjm-38	98	2	range	range	NOUN
bptjm-38	98	3	of	of	ADP
bptjm-38	98	4	age	age	NOUN
bptjm-38	98	5	of	of	ADP
bptjm-38	98	6	the	the	DET
bptjm-38	98	7	patients	patient	NOUN
bptjm-38	98	8	was	be	AUX
bptjm-38	98	9	between	between	ADP
bptjm-38	98	10	2	2	NUM
bptjm-38	98	11	to	to	PART
bptjm-38	98	12	18	18	NUM
bptjm-38	98	13	years	year	NOUN
bptjm-38	98	14	old	old	ADJ
bptjm-38	98	15	and	and	CCONJ
bptjm-38	98	16	included	include	VERB
bptjm-38	98	17	18	18	NUM
bptjm-38	98	18	females	female	NOUN
bptjm-38	98	19	and	and	CCONJ
bptjm-38	98	20	102	102	NUM
bptjm-38	98	21	males	male	NOUN
bptjm-38	98	22	.	.	PUNCT
bptjm-38	99	1	the	the	DET
bptjm-38	99	2	study	study	NOUN
bptjm-38	99	3	excluded	exclude	VERB
bptjm-38	99	4	patients	patient	NOUN
bptjm-38	99	5	with	with	ADP
bptjm-38	99	6	severe	severe	ADJ
bptjm-38	99	7	somatic	somatic	ADJ
bptjm-38	99	8	disorders	disorder	NOUN
bptjm-38	99	9	rrt	rrt	NOUN
bptjm-38	99	10	.	.	PUNCT
bptjm-38	100	1	18	18	NUM
bptjm-38	100	2	berkeley	berkeley	PROPN
bptjm-38	100	3	pharma	pharma	PROPN
bptjm-38	100	4	tech	tech	NOUN
bptjm-38	100	5	journal	journal	NOUN
bptjm-38	100	6	of	of	ADP
bptjm-38	100	7	medicine	medicine	NOUN
bptjm-38	100	8	|	|	ADV
bptjm-38	100	9	18	18	NUM
bptjm-38	100	10	in	in	ADP
bptjm-38	100	11	terms	term	NOUN
bptjm-38	100	12	of	of	ADP
bptjm-38	100	13	clinical	clinical	ADJ
bptjm-38	100	14	assessment	assessment	NOUN
bptjm-38	100	15	,	,	PUNCT
bptjm-38	100	16	comprehensive	comprehensive	ADJ
bptjm-38	100	17	pro	pro	X
bptjm-38	100	18	�	�	NOUN
bptjm-38	100	19	les	le	NOUN
bptjm-38	100	20	of	of	ADP
bptjm-38	100	21	each	each	DET
bptjm-38	100	22	patient	patient	NOUN
bptjm-38	100	23	were	be	AUX
bptjm-38	100	24	collected	collect	VERB
bptjm-38	100	25	in	in	ADP
bptjm-38	100	26	the	the	DET
bptjm-38	100	27	case	case	NOUN
bptjm-38	100	28	report	report	NOUN
bptjm-38	100	29	form	form	NOUN
bptjm-38	100	30	.	.	PUNCT
bptjm-38	101	1	researchers	researcher	NOUN
bptjm-38	101	2	classi	classi	PROPN
bptjm-38	101	3	�	�	PROPN
bptjm-38	101	4	ed	ed	PROPN
bptjm-38	101	5	the	the	DET
bptjm-38	101	6	symptoms	symptom	NOUN
bptjm-38	101	7	into	into	ADP
bptjm-38	101	8	4	4	NUM
bptjm-38	101	9	categories	category	NOUN
bptjm-38	101	10	:	:	PUNCT
bptjm-38	101	11	social	social	ADJ
bptjm-38	101	12	interaction	interaction	NOUN
bptjm-38	101	13	,	,	PUNCT
bptjm-38	101	14	language	language	NOUN
bptjm-38	101	15	,	,	PUNCT
bptjm-38	101	16	repetitive	repetitive	ADJ
bptjm-38	101	17	behaviors	behavior	NOUN
bptjm-38	101	18	,	,	PUNCT
bptjm-38	101	19	and	and	CCONJ
bptjm-38	101	20	functional	functional	ADJ
bptjm-38	101	21	impairment	impairment	NOUN
bptjm-38	101	22	.	.	PUNCT
bptjm-38	102	1	2–3	2–3	NUM
bptjm-38	102	2	μg	μg	PROPN
bptjm-38	102	3	of	of	ADP
bptjm-38	102	4	genomic	genomic	NOUN
bptjm-38	102	5	dna	dna	PROPN
bptjm-38	102	6	was	be	AUX
bptjm-38	102	7	extracted	extract	VERB
bptjm-38	102	8	from	from	ADP
bptjm-38	102	9	each	each	DET
bptjm-38	102	10	patient	patient	NOUN
bptjm-38	102	11	and	and	CCONJ
bptjm-38	102	12	libraries	library	NOUN
bptjm-38	102	13	in	in	ADP
bptjm-38	102	14	order	order	NOUN
bptjm-38	102	15	to	to	PART
bptjm-38	102	16	prepare	prepare	VERB
bptjm-38	102	17	cluster	cluster	NOUN
bptjm-38	102	18	generation	generation	NOUN
bptjm-38	102	19	and	and	CCONJ
bptjm-38	102	20	sequencing	sequencing	NOUN
bptjm-38	102	21	.	.	PUNCT
bptjm-38	103	1	based	base	VERB
bptjm-38	103	2	on	on	ADP
bptjm-38	103	3	the	the	DET
bptjm-38	103	4	patients	patient	NOUN
bptjm-38	103	5	’	'	PUNCT
bptjm-38	103	6	wes	wes	NOUN
bptjm-38	103	7	experiment	experiment	NOUN
bptjm-38	103	8	,	,	PUNCT
bptjm-38	103	9	families	family	NOUN
bptjm-38	103	10	within	within	ADP
bptjm-38	103	11	probands	proband	NOUN
bptjm-38	103	12	carrying	carry	VERB
bptjm-38	103	13	mecp2	mecp2	NOUN
bptjm-38	103	14	variations	variation	NOUN
bptjm-38	103	15	were	be	AUX
bptjm-38	103	16	selected	select	VERB
bptjm-38	103	17	for	for	ADP
bptjm-38	103	18	sanger	sanger	PROPN
bptjm-38	103	19	sequencing	sequence	VERB
bptjm-38	103	20	to	to	PART
bptjm-38	103	21	determine	determine	VERB
bptjm-38	103	22	if	if	SCONJ
bptjm-38	103	23	the	the	DET
bptjm-38	103	24	variations	variation	NOUN
bptjm-38	103	25	were	be	AUX
bptjm-38	103	26	de	de	X
bptjm-38	103	27	novo	novo	NOUN
bptjm-38	103	28	or	or	CCONJ
bptjm-38	103	29	inherited	inherit	VERB
bptjm-38	103	30	.	.	PUNCT
bptjm-38	104	1	the	the	DET
bptjm-38	104	2	wt	wt	PROPN
bptjm-38	104	3	mecp2	mecp2	NOUN
bptjm-38	104	4	gene	gene	NOUN
bptjm-38	104	5	(	(	PUNCT
bptjm-38	104	6	the	the	DET
bptjm-38	104	7	e2	e2	PROPN
bptjm-38	104	8	isoform	isoform	NOUN
bptjm-38	104	9	of	of	ADP
bptjm-38	104	10	rat	rat	NOUN
bptjm-38	104	11	mecp2	mecp2	NOUN
bptjm-38	104	12	cdna	cdna	PROPN
bptjm-38	104	13	)	)	PUNCT
bptjm-38	104	14	and	and	CCONJ
bptjm-38	104	15	other	other	ADJ
bptjm-38	104	16	mutated	mutate	VERB
bptjm-38	104	17	plasmids	plasmid	NOUN
bptjm-38	104	18	such	such	ADJ
bptjm-38	104	19	as	as	ADP
bptjm-38	104	20	mecp2	mecp2	NOUN
bptjm-38	104	21	-	-	PUNCT
bptjm-38	104	22	p152l	p152l	PROPN
bptjm-38	104	23	,	,	PUNCT
bptjm-38	104	24	mecp2	mecp2	NOUN
bptjm-38	104	25	-	-	PUNCT
bptjm-38	104	26	r294x	r294x	PROPN
bptjm-38	104	27	,	,	PUNCT
bptjm-38	104	28	and	and	CCONJ
bptjm-38	104	29	mecp2	mecp2	NOUN
bptjm-38	104	30	-	-	PUNCT
bptjm-38	104	31	p376s	p376s	PROPN
bptjm-38	104	32	were	be	AUX
bptjm-38	104	33	used	use	VERB
bptjm-38	104	34	to	to	PART
bptjm-38	104	35	detect	detect	VERB
bptjm-38	104	36	asd	asd	PROPN
bptjm-38	104	37	probands	proband	NOUN
bptjm-38	104	38	.	.	PUNCT
bptjm-38	105	1	18	18	NUM
bptjm-38	105	2	on	on	ADP
bptjm-38	105	3	days	day	NOUN
bptjm-38	105	4	15–16	15–16	NUM
bptjm-38	105	5	of	of	ADP
bptjm-38	105	6	mouse	mouse	PROPN
bptjm-38	105	7	embryo	embryo	NOUN
bptjm-38	105	8	development	development	NOUN
bptjm-38	105	9	,	,	PUNCT
bptjm-38	105	10	cortical	cortical	ADJ
bptjm-38	105	11	neurons	neuron	NOUN
bptjm-38	105	12	and	and	CCONJ
bptjm-38	105	13	hek-293	hek-293	NOUN
bptjm-38	105	14	cells	cell	NOUN
bptjm-38	105	15	were	be	AUX
bptjm-38	105	16	individually	individually	ADV
bptjm-38	105	17	cultured	cultured	ADJ
bptjm-38	105	18	and	and	CCONJ
bptjm-38	105	19	electrophoretically	electrophoretically	ADV
bptjm-38	105	20	transfected	transfecte	VERB
bptjm-38	105	21	into	into	ADP
bptjm-38	105	22	each	each	DET
bptjm-38	105	23	group	group	NOUN
bptjm-38	105	24	at	at	ADP
bptjm-38	105	25	0	0	NUM
bptjm-38	105	26	days	day	NOUN
bptjm-38	105	27	in	in	ADP
bptjm-38	105	28	vitro	vitro	X
bptjm-38	105	29	individual	individual	ADJ
bptjm-38	105	30	.	.	PUNCT
bptjm-38	106	1	hek-293	hek-293	NOUN
bptjm-38	106	2	cells	cell	NOUN
bptjm-38	106	3	and	and	CCONJ
bptjm-38	106	4	mouse	mouse	VERB
bptjm-38	106	5	cortical	cortical	ADJ
bptjm-38	106	6	neurons	neuron	NOUN
bptjm-38	106	7	were	be	AUX
bptjm-38	106	8	collected	collect	VERB
bptjm-38	106	9	after	after	ADP
bptjm-38	106	10	3	3	NUM
bptjm-38	106	11	days	day	NOUN
bptjm-38	106	12	in	in	ADP
bptjm-38	106	13	vitro	vitro	X
bptjm-38	106	14	for	for	ADP
bptjm-38	106	15	western	western	ADJ
bptjm-38	106	16	blot	blot	NOUN
bptjm-38	106	17	and	and	CCONJ
bptjm-38	106	18	immuno	immuno	PROPN
bptjm-38	106	19	�	�	PROPN
bptjm-38	106	20	uorescence	uorescence	NOUN
bptjm-38	106	21	analysis	analysis	NOUN
bptjm-38	106	22	,	,	PUNCT
bptjm-38	106	23	respectively	respectively	ADV
bptjm-38	106	24	.	.	PUNCT
bptjm-38	107	1	18	18	NUM
bptjm-38	107	2	5.2	5.2	NUM
bptjm-38	107	3	results	result	NOUN
bptjm-38	107	4	:	:	PUNCT
bptjm-38	107	5	three	three	NUM
bptjm-38	107	6	mutations	mutation	NOUN
bptjm-38	107	7	of	of	ADP
bptjm-38	107	8	mecp2	mecp2	NOUN
bptjm-38	107	9	were	be	AUX
bptjm-38	107	10	detected	detect	VERB
bptjm-38	107	11	among	among	ADP
bptjm-38	107	12	120	120	NUM
bptjm-38	107	13	asd	asd	NOUN
bptjm-38	107	14	patients	patient	NOUN
bptjm-38	107	15	via	via	ADP
bptjm-38	107	16	wes	wes	PROPN
bptjm-38	107	17	.	.	PUNCT
bptjm-38	108	1	p.p152l	p.p152l	PROPN
bptjm-38	108	2	(	(	PUNCT
bptjm-38	108	3	c.455c	c.455c	PROPN
bptjm-38	108	4	>	>	X
bptjm-38	108	5	t	t	PROPN
bptjm-38	108	6	)	)	PUNCT
bptjm-38	108	7	and	and	CCONJ
bptjm-38	108	8	p.p376s	p.p376	VERB
bptjm-38	108	9	(	(	PUNCT
bptjm-38	108	10	c.1162c	c.1162c	PROPN
bptjm-38	108	11	>	>	X
bptjm-38	108	12	t	t	PROPN
bptjm-38	108	13	)	)	PUNCT
bptjm-38	108	14	were	be	AUX
bptjm-38	108	15	missense	missense	NOUN
bptjm-38	108	16	mutations	mutation	NOUN
bptjm-38	108	17	and	and	CCONJ
bptjm-38	108	18	p.r294x	p.r294x	NOUN
bptjm-38	108	19	(	(	PUNCT
bptjm-38	108	20	c.880c	c.880c	PROPN
bptjm-38	108	21	>	>	SYM
bptjm-38	108	22	t	t	PROPN
bptjm-38	108	23	)	)	PUNCT
bptjm-38	108	24	was	be	AUX
bptjm-38	108	25	a	a	DET
bptjm-38	108	26	truncating	truncating	NOUN
bptjm-38	108	27	mutation	mutation	NOUN
bptjm-38	108	28	.	.	PUNCT
bptjm-38	109	1	sanger	sanger	PROPN
bptjm-38	109	2	sequencing	sequencing	PROPN
bptjm-38	109	3	showed	show	VERB
bptjm-38	109	4	that	that	SCONJ
bptjm-38	109	5	p.p152l	p.p152l	PROPN
bptjm-38	109	6	and	and	CCONJ
bptjm-38	109	7	p.r294x	p.r294x	PROPN
bptjm-38	109	8	were	be	AUX
bptjm-38	109	9	de	de	X
bptjm-38	109	10	novo	novo	NOUN
bptjm-38	109	11	mutations	mutation	NOUN
bptjm-38	109	12	,	,	PUNCT
bptjm-38	109	13	but	but	CCONJ
bptjm-38	109	14	p.p376s	p.p376s	NOUN
bptjm-38	109	15	was	be	AUX
bptjm-38	109	16	inherited	inherit	VERB
bptjm-38	109	17	maternally	maternally	ADV
bptjm-38	109	18	.	.	PUNCT
bptjm-38	110	1	they	they	PRON
bptjm-38	110	2	did	do	AUX
bptjm-38	110	3	not	not	PART
bptjm-38	110	4	�	�	VERB
bptjm-38	110	5	nd	nd	PRON
bptjm-38	110	6	any	any	PRON
bptjm-38	110	7	of	of	ADP
bptjm-38	110	8	these	these	DET
bptjm-38	110	9	mutations	mutation	NOUN
bptjm-38	110	10	in	in	ADP
bptjm-38	110	11	gnomad	gnomad	NOUN
bptjm-38	110	12	,	,	PUNCT
bptjm-38	110	13	indicating	indicate	VERB
bptjm-38	110	14	that	that	SCONJ
bptjm-38	110	15	they	they	PRON
bptjm-38	110	16	were	be	AUX
bptjm-38	110	17	rare	rare	ADJ
bptjm-38	110	18	mutations	mutation	NOUN
bptjm-38	110	19	.	.	PUNCT
bptjm-38	111	1	18	18	NUM
bptjm-38	111	2	in	in	ADP
bptjm-38	111	3	terms	term	NOUN
bptjm-38	111	4	of	of	ADP
bptjm-38	111	5	clinical	clinical	ADJ
bptjm-38	111	6	features	feature	NOUN
bptjm-38	111	7	,	,	PUNCT
bptjm-38	111	8	poor	poor	ADJ
bptjm-38	111	9	social	social	ADJ
bptjm-38	111	10	interaction	interaction	NOUN
bptjm-38	111	11	and	and	CCONJ
bptjm-38	111	12	functional	functional	ADJ
bptjm-38	111	13	impairment	impairment	NOUN
bptjm-38	111	14	were	be	AUX
bptjm-38	111	15	major	major	ADJ
bptjm-38	111	16	symptoms	symptom	NOUN
bptjm-38	111	17	for	for	ADP
bptjm-38	111	18	all	all	DET
bptjm-38	111	19	three	three	NUM
bptjm-38	111	20	mutations	mutation	NOUN
bptjm-38	111	21	,	,	PUNCT
bptjm-38	111	22	but	but	CCONJ
bptjm-38	111	23	language	language	NOUN
bptjm-38	111	24	use	use	NOUN
bptjm-38	111	25	and	and	CCONJ
bptjm-38	111	26	repetitive	repetitive	ADJ
bptjm-38	111	27	behavior	behavior	NOUN
bptjm-38	111	28	di	di	NOUN
bptjm-38	111	29	�	�	PROPN
bptjm-38	111	30	ered	ere	VERB
bptjm-38	111	31	greatly	greatly	ADV
bptjm-38	111	32	between	between	ADP
bptjm-38	111	33	them	they	PRON
bptjm-38	111	34	.	.	PUNCT
bptjm-38	112	1	also	also	ADV
bptjm-38	112	2	noted	note	VERB
bptjm-38	112	3	were	be	AUX
bptjm-38	112	4	abnormalities	abnormality	NOUN
bptjm-38	112	5	of	of	ADP
bptjm-38	112	6	dendritic	dendritic	ADJ
bptjm-38	112	7	and	and	CCONJ
bptjm-38	112	8	axonal	axonal	ADJ
bptjm-38	112	9	growth	growth	NOUN
bptjm-38	112	10	found	find	VERB
bptjm-38	112	11	after	after	SCONJ
bptjm-38	112	12	autism	autism	NOUN
bptjm-38	112	13	-	-	PUNCT
bptjm-38	112	14	related	relate	VERB
bptjm-38	112	15	mecp2	mecp2	NOUN
bptjm-38	112	16	mutants	mutant	NOUN
bptjm-38	112	17	were	be	AUX
bptjm-38	112	18	expressed	express	VERB
bptjm-38	112	19	in	in	ADP
bptjm-38	112	20	mouse	mouse	NOUN
bptjm-38	112	21	cortical	cortical	ADJ
bptjm-38	112	22	neurons	neuron	NOUN
bptjm-38	112	23	,	,	PUNCT
bptjm-38	112	24	suggesting	suggest	VERB
bptjm-38	112	25	that	that	SCONJ
bptjm-38	112	26	autism	autism	NOUN
bptjm-38	112	27	-	-	PUNCT
bptjm-38	112	28	related	relate	VERB
bptjm-38	112	29	mecp2	mecp2	NOUN
bptjm-38	112	30	mutations	mutation	NOUN
bptjm-38	112	31	impair	impair	VERB
bptjm-38	112	32	proper	proper	ADJ
bptjm-38	112	33	development	development	NOUN
bptjm-38	112	34	of	of	ADP
bptjm-38	112	35	neurons	neuron	NOUN
bptjm-38	112	36	.	.	PUNCT
bptjm-38	113	1	18	18	NUM
bptjm-38	113	2	the	the	DET
bptjm-38	113	3	results	result	NOUN
bptjm-38	113	4	strongly	strongly	ADV
bptjm-38	113	5	suggest	suggest	VERB
bptjm-38	113	6	that	that	SCONJ
bptjm-38	113	7	mecp2	mecp2	NOUN
bptjm-38	113	8	-	-	PUNCT
bptjm-38	113	9	p152l	p152l	PROPN
bptjm-38	113	10	,	,	PUNCT
bptjm-38	113	11	mecp2	mecp2	NOUN
bptjm-38	113	12	-	-	PUNCT
bptjm-38	113	13	r294x	r294x	PROPN
bptjm-38	113	14	,	,	PUNCT
bptjm-38	113	15	and	and	CCONJ
bptjm-38	113	16	mecp2	mecp2	NOUN
bptjm-38	113	17	-	-	PUNCT
bptjm-38	113	18	p376s	p376s	PROPN
bptjm-38	113	19	a	a	DET
bptjm-38	113	20	�	�	NOUN
bptjm-38	113	21	ect	ect	VERB
bptjm-38	113	22	the	the	DET
bptjm-38	113	23	proper	proper	ADJ
bptjm-38	113	24	physiological	physiological	ADJ
bptjm-38	113	25	function	function	NOUN
bptjm-38	113	26	of	of	ADP
bptjm-38	113	27	the	the	DET
bptjm-38	113	28	mecp2	mecp2	NOUN
bptjm-38	113	29	protein	protein	NOUN
bptjm-38	113	30	and	and	CCONJ
bptjm-38	113	31	may	may	AUX
bptjm-38	113	32	contribute	contribute	VERB
bptjm-38	113	33	to	to	ADP
bptjm-38	113	34	the	the	DET
bptjm-38	113	35	pathogenesis	pathogenesis	NOUN
bptjm-38	113	36	of	of	ADP
bptjm-38	113	37	autism	autism	NOUN
bptjm-38	113	38	.	.	PUNCT
bptjm-38	114	1	18	18	NUM
bptjm-38	114	2	berkeley	berkeley	PROPN
bptjm-38	114	3	pharma	pharma	PROPN
bptjm-38	114	4	tech	tech	NOUN
bptjm-38	114	5	journal	journal	NOUN
bptjm-38	114	6	of	of	ADP
bptjm-38	114	7	medicine	medicine	NOUN
bptjm-38	114	8	|	|	ADV
bptjm-38	114	9	19	19	NUM
bptjm-38	114	10	mecp2	mecp2	NOUN
bptjm-38	114	11	gene	gene	NOUN
bptjm-38	114	12	therapy	therapy	NOUN
bptjm-38	114	13	methods	method	NOUN
bptjm-38	114	14	in	in	ADP
bptjm-38	114	15	addition	addition	NOUN
bptjm-38	114	16	to	to	ADP
bptjm-38	114	17	these	these	DET
bptjm-38	114	18	studies	study	NOUN
bptjm-38	114	19	,	,	PUNCT
bptjm-38	114	20	there	there	PRON
bptjm-38	114	21	have	have	AUX
bptjm-38	114	22	been	be	AUX
bptjm-38	114	23	a	a	DET
bptjm-38	114	24	number	number	NOUN
bptjm-38	114	25	of	of	ADP
bptjm-38	114	26	experiments	experiment	NOUN
bptjm-38	114	27	utilizing	utilize	VERB
bptjm-38	114	28	gene	gene	NOUN
bptjm-38	114	29	therapy	therapy	NOUN
bptjm-38	114	30	for	for	ADP
bptjm-38	114	31	the	the	DET
bptjm-38	114	32	treatment	treatment	NOUN
bptjm-38	114	33	of	of	ADP
bptjm-38	114	34	asd	asd	NOUN
bptjm-38	114	35	.	.	PUNCT
bptjm-38	115	1	the	the	DET
bptjm-38	115	2	majority	majority	NOUN
bptjm-38	115	3	of	of	ADP
bptjm-38	115	4	these	these	DET
bptjm-38	115	5	trials	trial	NOUN
bptjm-38	115	6	have	have	AUX
bptjm-38	115	7	utilized	utilize	VERB
bptjm-38	115	8	a	a	DET
bptjm-38	115	9	viral	viral	ADJ
bptjm-38	115	10	vector	vector	NOUN
bptjm-38	115	11	to	to	PART
bptjm-38	115	12	deliver	deliver	VERB
bptjm-38	115	13	a	a	DET
bptjm-38	115	14	modi	modi	PROPN
bptjm-38	115	15	�	�	PROPN
bptjm-38	115	16	ed	ed	PROPN
bptjm-38	115	17	version	version	NOUN
bptjm-38	115	18	of	of	ADP
bptjm-38	115	19	the	the	DET
bptjm-38	115	20	mecp2	mecp2	NOUN
bptjm-38	115	21	gene	gene	NOUN
bptjm-38	115	22	to	to	ADP
bptjm-38	115	23	patients	patient	NOUN
bptjm-38	115	24	.	.	PUNCT
bptjm-38	116	1	the	the	DET
bptjm-38	116	2	results	result	NOUN
bptjm-38	116	3	of	of	ADP
bptjm-38	116	4	these	these	DET
bptjm-38	116	5	trials	trial	NOUN
bptjm-38	116	6	have	have	AUX
bptjm-38	116	7	been	be	AUX
bptjm-38	116	8	promising	promise	VERB
bptjm-38	116	9	,	,	PUNCT
bptjm-38	116	10	with	with	ADP
bptjm-38	116	11	patients	patient	NOUN
bptjm-38	116	12	exhibiting	exhibit	VERB
bptjm-38	116	13	improved	improve	VERB
bptjm-38	116	14	social	social	ADJ
bptjm-38	116	15	interaction	interaction	NOUN
bptjm-38	116	16	,	,	PUNCT
bptjm-38	116	17	better	well	ADJ
bptjm-38	116	18	communication	communication	NOUN
bptjm-38	116	19	skills	skill	NOUN
bptjm-38	116	20	,	,	PUNCT
bptjm-38	116	21	and	and	CCONJ
bptjm-38	116	22	an	an	DET
bptjm-38	116	23	improved	improved	ADJ
bptjm-38	116	24	quality	quality	NOUN
bptjm-38	116	25	of	of	ADP
bptjm-38	116	26	life	life	NOUN
bptjm-38	116	27	.	.	PUNCT
bptjm-38	117	1	6	6	NUM
bptjm-38	117	2	,	,	PUNCT
bptjm-38	117	3	19	19	NUM
bptjm-38	117	4	recombinant	recombinant	ADJ
bptjm-38	117	5	adeno	adeno	NOUN
bptjm-38	117	6	-	-	PUNCT
bptjm-38	117	7	associated	associate	VERB
bptjm-38	117	8	virus	virus	NOUN
bptjm-38	117	9	(	(	PUNCT
bptjm-38	117	10	raav)-delivered	raav)-delivered	ADJ
bptjm-38	117	11	gene	gene	NOUN
bptjm-38	117	12	substitution	substitution	NOUN
bptjm-38	117	13	has	have	AUX
bptjm-38	117	14	been	be	AUX
bptjm-38	117	15	shown	show	VERB
bptjm-38	117	16	to	to	PART
bptjm-38	117	17	improve	improve	VERB
bptjm-38	117	18	behavior	behavior	NOUN
bptjm-38	117	19	in	in	ADP
bptjm-38	117	20	several	several	ADJ
bptjm-38	117	21	investigations	investigation	NOUN
bptjm-38	117	22	employing	employ	VERB
bptjm-38	117	23	monogenic	monogenic	ADJ
bptjm-38	117	24	animal	animal	NOUN
bptjm-38	117	25	models	model	NOUN
bptjm-38	117	26	.	.	PUNCT
bptjm-38	118	1	for	for	ADP
bptjm-38	118	2	example	example	NOUN
bptjm-38	118	3	,	,	PUNCT
bptjm-38	118	4	a	a	DET
bptjm-38	118	5	recent	recent	ADJ
bptjm-38	118	6	study	study	NOUN
bptjm-38	118	7	has	have	AUX
bptjm-38	118	8	shown	show	VERB
bptjm-38	118	9	that	that	SCONJ
bptjm-38	118	10	systematic	systematic	ADJ
bptjm-38	118	11	administration	administration	NOUN
bptjm-38	118	12	of	of	ADP
bptjm-38	118	13	a	a	DET
bptjm-38	118	14	raav9	raav9	NOUN
bptjm-38	118	15	-	-	PUNCT
bptjm-38	118	16	mecp2	mecp2	NOUN
bptjm-38	118	17	vector	vector	NOUN
bptjm-38	118	18	su	su	PROPN
bptjm-38	118	19	�	�	PROPN
bptjm-38	118	20	cient	cient	VERB
bptjm-38	118	21	for	for	ADP
bptjm-38	118	22	10	10	NUM
bptjm-38	118	23	%	%	NOUN
bptjm-38	118	24	cns	cns	NOUN
bptjm-38	118	25	transduction	transduction	NOUN
bptjm-38	118	26	(	(	PUNCT
bptjm-38	118	27	of	of	ADP
bptjm-38	118	28	primarily	primarily	ADV
bptjm-38	118	29	neuronal	neuronal	ADJ
bptjm-38	118	30	cells	cell	NOUN
bptjm-38	118	31	)	)	PUNCT
bptjm-38	118	32	in	in	ADP
bptjm-38	118	33	an	an	DET
bptjm-38	118	34	rs	rs	ADJ
bptjm-38	118	35	animal	animal	NOUN
bptjm-38	118	36	model	model	NOUN
bptjm-38	118	37	resulted	result	VERB
bptjm-38	118	38	in	in	ADP
bptjm-38	118	39	modest	modest	ADJ
bptjm-38	118	40	behavioral	behavioral	ADJ
bptjm-38	118	41	improvements	improvement	NOUN
bptjm-38	118	42	.	.	PUNCT
bptjm-38	119	1	6	6	NUM
bptjm-38	119	2	comparatively	comparatively	ADV
bptjm-38	119	3	,	,	PUNCT
bptjm-38	119	4	25	25	NUM
bptjm-38	119	5	%	%	NOUN
bptjm-38	119	6	cns	cns	NOUN
bptjm-38	119	7	transduction	transduction	NOUN
bptjm-38	119	8	at	at	ADP
bptjm-38	119	9	a	a	DET
bptjm-38	119	10	6	6	NUM
bptjm-38	119	11	-	-	ADJ
bptjm-38	119	12	fold	fold	ADJ
bptjm-38	119	13	higher	high	ADJ
bptjm-38	119	14	vector	vector	NOUN
bptjm-38	119	15	dose	dose	NOUN
bptjm-38	119	16	led	lead	VERB
bptjm-38	119	17	to	to	ADP
bptjm-38	119	18	noticeable	noticeable	ADJ
bptjm-38	119	19	behavioral	behavioral	ADJ
bptjm-38	119	20	and	and	CCONJ
bptjm-38	119	21	phenotypic	phenotypic	ADJ
bptjm-38	119	22	bene	bene	PROPN
bptjm-38	119	23	�	�	PROPN
bptjm-38	119	24	ts	ts	NOUN
bptjm-38	119	25	.	.	PROPN
bptjm-38	119	26	19	19	NUM
bptjm-38	119	27	a	a	DET
bptjm-38	119	28	promising	promising	ADJ
bptjm-38	119	29	mecp2	mecp2	NOUN
bptjm-38	119	30	gene	gene	NOUN
bptjm-38	119	31	therapy	therapy	NOUN
bptjm-38	119	32	strategy	strategy	NOUN
bptjm-38	119	33	is	be	AUX
bptjm-38	119	34	using	use	VERB
bptjm-38	119	35	antisense	antisense	NOUN
bptjm-38	119	36	oligonucleotides	oligonucleotide	NOUN
bptjm-38	119	37	.	.	PUNCT
bptjm-38	120	1	antisense	antisense	NOUN
bptjm-38	120	2	oligonucleotides	oligonucleotide	NOUN
bptjm-38	120	3	are	be	AUX
bptjm-38	120	4	small	small	ADJ
bptjm-38	120	5	,	,	PUNCT
bptjm-38	120	6	modi	modi	PROPN
bptjm-38	120	7	�	�	PROPN
bptjm-38	120	8	ed	ed	PROPN
bptjm-38	120	9	nucleic	nucleic	ADJ
bptjm-38	120	10	acids	acid	NOUN
bptjm-38	120	11	that	that	PRON
bptjm-38	120	12	can	can	AUX
bptjm-38	120	13	selectively	selectively	ADV
bptjm-38	120	14	hybridize	hybridize	VERB
bptjm-38	120	15	with	with	ADP
bptjm-38	120	16	m	m	NOUN
bptjm-38	120	17	-	-	NOUN
bptjm-38	120	18	rna	rna	NOUN
bptjm-38	120	19	from	from	ADP
bptjm-38	120	20	a	a	DET
bptjm-38	120	21	target	target	NOUN
bptjm-38	120	22	gene	gene	NOUN
bptjm-38	120	23	and	and	CCONJ
bptjm-38	120	24	silence	silence	VERB
bptjm-38	120	25	it	it	PRON
bptjm-38	120	26	.	.	PUNCT
bptjm-38	121	1	mecp2	mecp2	NOUN
bptjm-38	121	2	duplication	duplication	NOUN
bptjm-38	121	3	syndrome	syndrome	NOUN
bptjm-38	121	4	has	have	AUX
bptjm-38	121	5	been	be	AUX
bptjm-38	121	6	associated	associate	VERB
bptjm-38	121	7	with	with	ADP
bptjm-38	121	8	autism	autism	NOUN
bptjm-38	121	9	,	,	PUNCT
bptjm-38	121	10	intellectual	intellectual	ADJ
bptjm-38	121	11	disability	disability	NOUN
bptjm-38	121	12	,	,	PUNCT
bptjm-38	121	13	motor	motor	NOUN
bptjm-38	121	14	dysfunction	dysfunction	NOUN
bptjm-38	121	15	,	,	PUNCT
bptjm-38	121	16	and	and	CCONJ
bptjm-38	121	17	anxiety	anxiety	NOUN
bptjm-38	121	18	,	,	PUNCT
bptjm-38	121	19	and	and	CCONJ
bptjm-38	121	20	is	be	AUX
bptjm-38	121	21	one	one	NUM
bptjm-38	121	22	of	of	ADP
bptjm-38	121	23	the	the	DET
bptjm-38	121	24	most	most	ADV
bptjm-38	121	25	common	common	ADJ
bptjm-38	121	26	genomic	genomic	ADJ
bptjm-38	121	27	rearrangements	rearrangement	NOUN
bptjm-38	121	28	seen	see	VERB
bptjm-38	121	29	in	in	ADP
bptjm-38	121	30	male	male	ADJ
bptjm-38	121	31	patients	patient	NOUN
bptjm-38	121	32	.	.	PUNCT
bptjm-38	122	1	the	the	DET
bptjm-38	122	2	cause	cause	NOUN
bptjm-38	122	3	of	of	ADP
bptjm-38	122	4	these	these	DET
bptjm-38	122	5	de	de	PROPN
bptjm-38	122	6	�	�	PROPN
bptjm-38	122	7	cits	cit	NOUN
bptjm-38	122	8	is	be	AUX
bptjm-38	122	9	the	the	DET
bptjm-38	122	10	over	over	ADP
bptjm-38	122	11	-	-	PUNCT
bptjm-38	122	12	expression	expression	NOUN
bptjm-38	122	13	of	of	ADP
bptjm-38	122	14	methyl	methyl	NOUN
bptjm-38	122	15	-	-	PUNCT
bptjm-38	122	16	cpg	cpg	NOUN
bptjm-38	122	17	-	-	PUNCT
bptjm-38	122	18	binding	bind	VERB
bptjm-38	122	19	protein	protein	NOUN
bptjm-38	122	20	2	2	NUM
bptjm-38	122	21	(	(	PUNCT
bptjm-38	122	22	mecp2	mecp2	NOUN
bptjm-38	122	23	)	)	PUNCT
bptjm-38	122	24	.	.	PUNCT
bptjm-38	123	1	this	this	DET
bptjm-38	123	2	syndrome	syndrome	NOUN
bptjm-38	123	3	poses	pose	VERB
bptjm-38	123	4	a	a	DET
bptjm-38	123	5	challenge	challenge	NOUN
bptjm-38	123	6	to	to	ADP
bptjm-38	123	7	traditional	traditional	ADJ
bptjm-38	123	8	therapeutic	therapeutic	ADJ
bptjm-38	123	9	approaches	approach	NOUN
bptjm-38	123	10	.	.	PUNCT
bptjm-38	124	1	19	19	NUM
bptjm-38	124	2	some	some	DET
bptjm-38	124	3	symptomatic	symptomatic	ADJ
bptjm-38	124	4	mice	mice	NOUN
bptjm-38	124	5	models	model	NOUN
bptjm-38	124	6	of	of	ADP
bptjm-38	124	7	monogenic	monogenic	ADJ
bptjm-38	124	8	loss	loss	NOUN
bptjm-38	124	9	of	of	ADP
bptjm-38	124	10	function	function	NOUN
bptjm-38	124	11	neurological	neurological	ADJ
bptjm-38	124	12	disorders	disorder	NOUN
bptjm-38	124	13	,	,	PUNCT
bptjm-38	124	14	including	include	VERB
bptjm-38	124	15	the	the	DET
bptjm-38	124	16	loss	loss	NOUN
bptjm-38	124	17	of	of	ADP
bptjm-38	124	18	mecp2	mecp2	NOUN
bptjm-38	124	19	in	in	ADP
bptjm-38	124	20	rett	rett	PROPN
bptjm-38	124	21	syndrome	syndrome	PROPN
bptjm-38	124	22	,	,	PUNCT
bptjm-38	124	23	have	have	AUX
bptjm-38	124	24	demonstrated	demonstrate	VERB
bptjm-38	124	25	reversal	reversal	NOUN
bptjm-38	124	26	of	of	ADP
bptjm-38	124	27	phenotypes	phenotype	NOUN
bptjm-38	124	28	,	,	PUNCT
bptjm-38	124	29	indicating	indicate	VERB
bptjm-38	124	30	that	that	SCONJ
bptjm-38	124	31	the	the	DET
bptjm-38	124	32	molecular	molecular	ADJ
bptjm-38	124	33	correction	correction	NOUN
bptjm-38	124	34	of	of	ADP
bptjm-38	124	35	the	the	DET
bptjm-38	124	36	underlying	underlie	VERB
bptjm-38	124	37	dysfunction	dysfunction	NOUN
bptjm-38	124	38	could	could	AUX
bptjm-38	124	39	potentially	potentially	ADV
bptjm-38	124	40	restore	restore	VERB
bptjm-38	124	41	typical	typical	ADJ
bptjm-38	124	42	physiology	physiology	NOUN
bptjm-38	124	43	.	.	PUNCT
bptjm-38	125	1	the	the	DET
bptjm-38	125	2	study	study	NOUN
bptjm-38	125	3	focused	focus	VERB
bptjm-38	125	4	on	on	ADP
bptjm-38	125	5	the	the	DET
bptjm-38	125	6	restoration	restoration	NOUN
bptjm-38	125	7	of	of	ADP
bptjm-38	125	8	normal	normal	ADJ
bptjm-38	125	9	mecp2	mecp2	NOUN
bptjm-38	125	10	levels	level	NOUN
bptjm-38	125	11	in	in	ADP
bptjm-38	125	12	mecp2	mecp2	NOUN
bptjm-38	125	13	duplication	duplication	NOUN
bptjm-38	125	14	syndrome	syndrome	NOUN
bptjm-38	125	15	using	use	VERB
bptjm-38	125	16	mice	mouse	NOUN
bptjm-38	125	17	models	model	NOUN
bptjm-38	125	18	.	.	PUNCT
bptjm-38	126	1	17	17	NUM
bptjm-38	126	2	,	,	PUNCT
bptjm-38	126	3	19	19	NUM
bptjm-38	126	4	berkeley	berkeley	PROPN
bptjm-38	126	5	pharma	pharma	PROPN
bptjm-38	126	6	tech	tech	NOUN
bptjm-38	126	7	journal	journal	NOUN
bptjm-38	126	8	of	of	ADP
bptjm-38	126	9	medicine	medicine	NOUN
bptjm-38	126	10	|	|	ADV
bptjm-38	126	11	20	20	NUM
bptjm-38	126	12	figure	figure	NOUN
bptjm-38	126	13	5	5	NUM
bptjm-38	126	14	:	:	PUNCT
bptjm-38	126	15	methods	method	NOUN
bptjm-38	126	16	used	use	VERB
bptjm-38	126	17	in	in	ADP
bptjm-38	126	18	sztainberg	sztainberg	PROPN
bptjm-38	126	19	et	et	PROPN
bptjm-38	126	20	al	al	PROPN
bptjm-38	126	21	.	.	PUNCT
bptjm-38	127	1	trials	trial	NOUN
bptjm-38	127	2	testing	test	VERB
bptjm-38	127	3	use	use	NOUN
bptjm-38	127	4	of	of	ADP
bptjm-38	127	5	humanspeci	humanspeci	NOUN
bptjm-38	127	6	�	�	PROPN
bptjm-38	127	7	c	c	NOUN
bptjm-38	127	8	antisense	antisense	NOUN
bptjm-38	127	9	oligonucleotides	oligonucleotide	NOUN
bptjm-38	127	10	(	(	PUNCT
bptjm-38	127	11	asos	asos	NOUN
bptjm-38	127	12	)	)	PUNCT
bptjm-38	127	13	to	to	PART
bptjm-38	127	14	normalize	normalize	VERB
bptjm-38	127	15	necp2	necp2	NOUN
bptjm-38	127	16	levels	level	NOUN
bptjm-38	127	17	in	in	ADP
bptjm-38	127	18	mouse	mouse	NOUN
bptjm-38	127	19	models	model	NOUN
bptjm-38	127	20	the	the	DET
bptjm-38	127	21	contributors	contributor	NOUN
bptjm-38	127	22	generated	generate	VERB
bptjm-38	127	23	a	a	DET
bptjm-38	127	24	conditional	conditional	ADJ
bptjm-38	127	25	mecp2	mecp2	NOUN
bptjm-38	127	26	overexpression	overexpression	NOUN
bptjm-38	127	27	mouse	mouse	NOUN
bptjm-38	127	28	model	model	NOUN
bptjm-38	127	29	and	and	CCONJ
bptjm-38	127	30	showed	show	VERB
bptjm-38	127	31	that	that	SCONJ
bptjm-38	127	32	the	the	DET
bptjm-38	127	33	correction	correction	NOUN
bptjm-38	127	34	of	of	ADP
bptjm-38	127	35	mecp2	mecp2	NOUN
bptjm-38	127	36	levels	level	NOUN
bptjm-38	127	37	e	e	VERB
bptjm-38	127	38	�	�	NOUN
bptjm-38	127	39	ectively	ectively	ADV
bptjm-38	127	40	reversed	reverse	VERB
bptjm-38	127	41	the	the	DET
bptjm-38	127	42	molecular	molecular	ADJ
bptjm-38	127	43	,	,	PUNCT
bptjm-38	127	44	electrophysiological	electrophysiological	ADJ
bptjm-38	127	45	,	,	PUNCT
bptjm-38	127	46	and	and	CCONJ
bptjm-38	127	47	phenotypic	phenotypic	ADJ
bptjm-38	127	48	de	de	PROPN
bptjm-38	127	49	�	�	PROPN
bptjm-38	127	50	cits	cit	NOUN
bptjm-38	127	51	using	use	VERB
bptjm-38	127	52	antisense	antisense	NOUN
bptjm-38	127	53	oligonucleotides	oligonucleotide	NOUN
bptjm-38	127	54	(	(	PUNCT
bptjm-38	127	55	aso	aso	NOUN
bptjm-38	127	56	)	)	PUNCT
bptjm-38	127	57	.	.	PUNCT
bptjm-38	128	1	it	it	PRON
bptjm-38	128	2	was	be	AUX
bptjm-38	128	3	found	find	VERB
bptjm-38	128	4	that	that	SCONJ
bptjm-38	128	5	antisense	antisense	NOUN
bptjm-38	128	6	oligonucleotide	oligonucleotide	NOUN
bptjm-38	128	7	treatment	treatment	NOUN
bptjm-38	128	8	resulted	result	VERB
bptjm-38	128	9	in	in	ADP
bptjm-38	128	10	broad	broad	ADJ
bptjm-38	128	11	phenotypic	phenotypic	ADJ
bptjm-38	128	12	rescue	rescue	NOUN
bptjm-38	128	13	in	in	ADP
bptjm-38	128	14	symptomatic	symptomatic	ADJ
bptjm-38	128	15	transgenic	transgenic	NOUN
bptjm-38	128	16	mecp2	mecp2	NOUN
bptjm-38	128	17	duplication	duplication	NOUN
bptjm-38	128	18	mice	mouse	NOUN
bptjm-38	128	19	and	and	CCONJ
bptjm-38	128	20	corrected	correct	VERB
bptjm-38	128	21	mecp2	mecp2	NOUN
bptjm-38	128	22	levels	level	NOUN
bptjm-38	128	23	in	in	ADP
bptjm-38	128	24	lymphoblastoid	lymphoblastoid	NOUN
bptjm-38	128	25	cells	cell	NOUN
bptjm-38	128	26	in	in	ADP
bptjm-38	128	27	a	a	DET
bptjm-38	128	28	dose	dose	ADJ
bptjm-38	128	29	dependent	dependent	ADJ
bptjm-38	128	30	manner	manner	NOUN
bptjm-38	128	31	.	.	PUNCT
bptjm-38	129	1	19	19	NUM
bptjm-38	129	2	experimental	experimental	ADJ
bptjm-38	129	3	results	result	NOUN
bptjm-38	129	4	suggest	suggest	VERB
bptjm-38	129	5	that	that	SCONJ
bptjm-38	129	6	delivery	delivery	NOUN
bptjm-38	129	7	of	of	ADP
bptjm-38	129	8	asos	asos	PROPN
bptjm-38	129	9	to	to	ADP
bptjm-38	129	10	cns	cns	PROPN
bptjm-38	129	11	could	could	AUX
bptjm-38	129	12	prove	prove	VERB
bptjm-38	129	13	to	to	PART
bptjm-38	129	14	be	be	AUX
bptjm-38	129	15	promising	promise	VERB
bptjm-38	129	16	for	for	ADP
bptjm-38	129	17	treating	treat	VERB
bptjm-38	129	18	mecp2	mecp2	NOUN
bptjm-38	129	19	duplication	duplication	NOUN
bptjm-38	129	20	syndrome	syndrome	NOUN
bptjm-38	129	21	,	,	PUNCT
bptjm-38	129	22	with	with	ADP
bptjm-38	129	23	potential	potential	ADJ
bptjm-38	129	24	applications	application	NOUN
bptjm-38	129	25	in	in	ADP
bptjm-38	129	26	asd	asd	PROPN
bptjm-38	129	27	and	and	CCONJ
bptjm-38	129	28	rett	rett	PROPN
bptjm-38	129	29	syndrome	syndrome	PROPN
bptjm-38	129	30	.	.	PUNCT
bptjm-38	130	1	future	future	ADJ
bptjm-38	130	2	directions	direction	NOUN
bptjm-38	130	3	should	should	AUX
bptjm-38	130	4	focus	focus	VERB
bptjm-38	130	5	on	on	ADP
bptjm-38	130	6	testing	test	VERB
bptjm-38	130	7	di	di	PROPN
bptjm-38	130	8	�	�	PROPN
bptjm-38	130	9	erent	erent	NOUN
bptjm-38	130	10	aso	aso	NOUN
bptjm-38	130	11	dosages	dosage	NOUN
bptjm-38	130	12	,	,	PUNCT
bptjm-38	130	13	determining	determine	VERB
bptjm-38	130	14	safety	safety	NOUN
bptjm-38	130	15	margins	margin	NOUN
bptjm-38	130	16	of	of	ADP
bptjm-38	130	17	mecp2	mecp2	NOUN
bptjm-38	130	18	levels	level	NOUN
bptjm-38	130	19	,	,	PUNCT
bptjm-38	130	20	and	and	CCONJ
bptjm-38	130	21	screening	screen	VERB
bptjm-38	130	22	mecp2	mecp2	NOUN
bptjm-38	130	23	asos	asos	NOUN
bptjm-38	130	24	for	for	ADP
bptjm-38	130	25	o	o	NOUN
bptjm-38	130	26	�	�	PROPN
bptjm-38	130	27	-target	-target	ADJ
bptjm-38	130	28	e	e	NOUN
bptjm-38	130	29	�	�	NOUN
bptjm-38	130	30	ects	ect	NOUN
bptjm-38	130	31	.	.	PUNCT
bptjm-38	131	1	19	19	NUM
bptjm-38	131	2	antisense	antisense	NOUN
bptjm-38	131	3	oligonucleotides	oligonucleotide	NOUN
bptjm-38	131	4	(	(	PUNCT
bptjm-38	131	5	asos	asos	NOUN
bptjm-38	131	6	)	)	PUNCT
bptjm-38	131	7	and	and	CCONJ
bptjm-38	131	8	short	short	ADJ
bptjm-38	131	9	interfering	interfere	VERB
bptjm-38	131	10	rnas	rna	NOUN
bptjm-38	131	11	(	(	PUNCT
bptjm-38	131	12	sirnas	sirnas	PROPN
bptjm-38	131	13	)	)	PUNCT
bptjm-38	131	14	are	be	AUX
bptjm-38	131	15	two	two	NUM
bptjm-38	131	16	methods	method	NOUN
bptjm-38	131	17	for	for	ADP
bptjm-38	131	18	sequence	sequence	NOUN
bptjm-38	131	19	-	-	PUNCT
bptjm-38	131	20	speci	speci	NOUN
bptjm-38	131	21	�	�	PROPN
bptjm-38	131	22	c	c	NOUN
bptjm-38	131	23	suppression	suppression	NOUN
bptjm-38	131	24	of	of	ADP
bptjm-38	131	25	mrna	mrna	PROPN
bptjm-38	131	26	transcripts	transcript	NOUN
bptjm-38	131	27	which	which	PRON
bptjm-38	131	28	can	can	AUX
bptjm-38	131	29	then	then	ADV
bptjm-38	131	30	be	be	AUX
bptjm-38	131	31	used	use	VERB
bptjm-38	131	32	to	to	PART
bptjm-38	131	33	mute	mute	VERB
bptjm-38	131	34	gene	gene	NOUN
bptjm-38	131	35	expression	expression	NOUN
bptjm-38	131	36	.	.	PUNCT
bptjm-38	132	1	in	in	ADP
bptjm-38	132	2	a	a	DET
bptjm-38	132	3	conditional	conditional	ADJ
bptjm-38	132	4	mecp2	mecp2	NOUN
bptjm-38	132	5	-	-	PUNCT
bptjm-38	132	6	overexpressing	overexpresse	VERB
bptjm-38	132	7	mouse	mouse	NOUN
bptjm-38	132	8	model	model	NOUN
bptjm-38	132	9	of	of	ADP
bptjm-38	132	10	mecp2	mecp2	NOUN
bptjm-38	132	11	duplication	duplication	NOUN
bptjm-38	132	12	syndrome	syndrome	NOUN
bptjm-38	132	13	,	,	PUNCT
bptjm-38	132	14	it	it	PRON
bptjm-38	132	15	was	be	AUX
bptjm-38	132	16	demonstrated	demonstrate	VERB
bptjm-38	132	17	that	that	SCONJ
bptjm-38	132	18	halving	halve	VERB
bptjm-38	132	19	mecp2	mecp2	NOUN
bptjm-38	132	20	expression	expression	NOUN
bptjm-38	132	21	restored	restore	VERB
bptjm-38	132	22	cellular	cellular	ADJ
bptjm-38	132	23	function	function	NOUN
bptjm-38	132	24	and	and	CCONJ
bptjm-38	132	25	phenotype	phenotype	NOUN
bptjm-38	132	26	postnatally	postnatally	ADV
bptjm-38	132	27	.	.	PUNCT
bptjm-38	133	1	the	the	DET
bptjm-38	133	2	same	same	ADJ
bptjm-38	133	3	study	study	NOUN
bptjm-38	133	4	found	find	VERB
bptjm-38	133	5	that	that	SCONJ
bptjm-38	133	6	intraventricular	intraventricular	ADJ
bptjm-38	133	7	delivery	delivery	NOUN
bptjm-38	133	8	of	of	ADP
bptjm-38	133	9	asos	asos	PROPN
bptjm-38	133	10	speci	speci	PROPN
bptjm-38	133	11	�	�	PROPN
bptjm-38	133	12	cally	cally	ADV
bptjm-38	133	13	directed	direct	VERB
bptjm-38	133	14	against	against	ADP
bptjm-38	133	15	mecp2	mecp2	NOUN
bptjm-38	133	16	caused	cause	VERB
bptjm-38	133	17	widespread	widespread	ADJ
bptjm-38	133	18	aso	aso	NOUN
bptjm-38	133	19	dispersion	dispersion	NOUN
bptjm-38	133	20	throughout	throughout	ADP
bptjm-38	133	21	the	the	DET
bptjm-38	133	22	cns	cns	NOUN
bptjm-38	133	23	.	.	PUNCT
bptjm-38	134	1	this	this	PRON
bptjm-38	134	2	resulted	result	VERB
bptjm-38	134	3	in	in	ADP
bptjm-38	134	4	e	e	PROPN
bptjm-38	134	5	�	�	PROPN
bptjm-38	134	6	cient	cient	NOUN
bptjm-38	134	7	knockdown	knockdown	NOUN
bptjm-38	134	8	of	of	ADP
bptjm-38	134	9	mecp2	mecp2	NOUN
bptjm-38	134	10	to	to	ADP
bptjm-38	134	11	levels	level	NOUN
bptjm-38	134	12	close	close	ADV
bptjm-38	134	13	to	to	ADP
bptjm-38	134	14	wildtype	wildtype	NOUN
bptjm-38	134	15	and	and	CCONJ
bptjm-38	134	16	a	a	DET
bptjm-38	134	17	long	long	ADV
bptjm-38	134	18	-	-	PUNCT
bptjm-38	134	19	lasting	last	VERB
bptjm-38	134	20	phenotypic	phenotypic	ADJ
bptjm-38	134	21	reversal	reversal	NOUN
bptjm-38	134	22	.	.	PUNCT
bptjm-38	135	1	both	both	DET
bptjm-38	135	2	studies	study	NOUN
bptjm-38	135	3	suggest	suggest	VERB
bptjm-38	135	4	gene	gene	NOUN
bptjm-38	135	5	replacement	replacement	NOUN
bptjm-38	135	6	and	and	CCONJ
bptjm-38	135	7	rna	rna	NOUN
bptjm-38	135	8	knockdown	knockdown	NOUN
bptjm-38	135	9	of	of	ADP
bptjm-38	135	10	mecp2	mecp2	NOUN
bptjm-38	135	11	gene	gene	NOUN
bptjm-38	135	12	may	may	AUX
bptjm-38	135	13	be	be	AUX
bptjm-38	135	14	a	a	DET
bptjm-38	135	15	method	method	NOUN
bptjm-38	135	16	worth	worth	ADJ
bptjm-38	135	17	exploring	explore	VERB
bptjm-38	135	18	as	as	ADP
bptjm-38	135	19	a	a	DET
bptjm-38	135	20	possible	possible	ADJ
bptjm-38	135	21	remedy	remedy	NOUN
bptjm-38	135	22	for	for	ADP
bptjm-38	135	23	asd	asd	PROPN
bptjm-38	135	24	.	.	PROPN
bptjm-38	135	25	19	19	NUM
bptjm-38	135	26	berkeley	berkeley	PROPN
bptjm-38	135	27	pharma	pharma	PROPN
bptjm-38	135	28	tech	tech	NOUN
bptjm-38	135	29	journal	journal	NOUN
bptjm-38	135	30	of	of	ADP
bptjm-38	135	31	medicine	medicine	NOUN
bptjm-38	135	32	|	|	ADV
bptjm-38	135	33	21	21	NUM
bptjm-38	135	34	future	future	ADJ
bptjm-38	135	35	directions	direction	NOUN
bptjm-38	135	36	in	in	ADP
bptjm-38	135	37	addition	addition	NOUN
bptjm-38	135	38	to	to	ADP
bptjm-38	135	39	the	the	DET
bptjm-38	135	40	aforementioned	aforementione	VERB
bptjm-38	135	41	genetic	genetic	NOUN
bptjm-38	135	42	in	in	ADP
bptjm-38	135	43	�	�	NOUN
bptjm-38	135	44	uences	uence	NOUN
bptjm-38	135	45	on	on	ADP
bptjm-38	135	46	asd	asd	PROPN
bptjm-38	135	47	cases	case	NOUN
bptjm-38	135	48	,	,	PUNCT
bptjm-38	135	49	there	there	PRON
bptjm-38	135	50	are	be	VERB
bptjm-38	135	51	other	other	ADJ
bptjm-38	135	52	factors	factor	NOUN
bptjm-38	135	53	that	that	PRON
bptjm-38	135	54	can	can	AUX
bptjm-38	135	55	impact	impact	VERB
bptjm-38	135	56	the	the	DET
bptjm-38	135	57	pathophysiology	pathophysiology	NOUN
bptjm-38	135	58	of	of	ADP
bptjm-38	135	59	asd	asd	PROPN
bptjm-38	135	60	.	.	PUNCT
bptjm-38	136	1	for	for	ADP
bptjm-38	136	2	example	example	NOUN
bptjm-38	136	3	,	,	PUNCT
bptjm-38	136	4	many	many	ADJ
bptjm-38	136	5	autism	autism	NOUN
bptjm-38	136	6	patients	patient	NOUN
bptjm-38	136	7	have	have	AUX
bptjm-38	136	8	reported	report	VERB
bptjm-38	136	9	gastrointestinal	gastrointestinal	ADJ
bptjm-38	136	10	disorders	disorder	NOUN
bptjm-38	136	11	(	(	PUNCT
bptjm-38	136	12	gi	gi	NOUN
bptjm-38	136	13	)	)	PUNCT
bptjm-38	136	14	.	.	PUNCT
bptjm-38	137	1	this	this	PRON
bptjm-38	137	2	has	have	AUX
bptjm-38	137	3	prompted	prompt	VERB
bptjm-38	137	4	interest	interest	NOUN
bptjm-38	137	5	in	in	ADP
bptjm-38	137	6	possible	possible	ADJ
bptjm-38	137	7	relationships	relationship	NOUN
bptjm-38	137	8	between	between	ADP
bptjm-38	137	9	the	the	DET
bptjm-38	137	10	gut	gut	NOUN
bptjm-38	137	11	microbiome	microbiome	NOUN
bptjm-38	137	12	and	and	CCONJ
bptjm-38	137	13	autism	autism	NOUN
bptjm-38	137	14	.	.	PUNCT
bptjm-38	138	1	7	7	NUM
bptjm-38	138	2	up	up	ADP
bptjm-38	138	3	to	to	PART
bptjm-38	138	4	70	70	NUM
bptjm-38	138	5	%	%	NOUN
bptjm-38	138	6	of	of	ADP
bptjm-38	138	7	autism	autism	NOUN
bptjm-38	138	8	patients	patient	NOUN
bptjm-38	138	9	have	have	AUX
bptjm-38	138	10	reported	report	VERB
bptjm-38	138	11	dealing	deal	VERB
bptjm-38	138	12	with	with	ADP
bptjm-38	138	13	gi	gi	NOUN
bptjm-38	138	14	disorders	disorder	NOUN
bptjm-38	138	15	.	.	PUNCT
bptjm-38	139	1	these	these	DET
bptjm-38	139	2	gi	gi	NOUN
bptjm-38	139	3	disorders	disorder	NOUN
bptjm-38	139	4	can	can	AUX
bptjm-38	139	5	be	be	AUX
bptjm-38	139	6	a	a	DET
bptjm-38	139	7	result	result	NOUN
bptjm-38	139	8	of	of	ADP
bptjm-38	139	9	dysbiosis	dysbiosis	NOUN
bptjm-38	139	10	,	,	PUNCT
bptjm-38	139	11	an	an	DET
bptjm-38	139	12	imbalanced	imbalanced	ADJ
bptjm-38	139	13	gut	gut	NOUN
bptjm-38	139	14	microbiome	microbiome	NOUN
bptjm-38	139	15	,	,	PUNCT
bptjm-38	139	16	characterized	characterize	VERB
bptjm-38	139	17	by	by	ADP
bptjm-38	139	18	reduced	reduce	VERB
bptjm-38	139	19	microbial	microbial	ADJ
bptjm-38	139	20	diversity	diversity	NOUN
bptjm-38	139	21	and	and	CCONJ
bptjm-38	139	22	increased	increase	VERB
bptjm-38	139	23	micro	micro	PROPN
bptjm-38	139	24	�	�	PROPN
bptjm-38	139	25	ora	ora	PROPN
bptjm-38	139	26	in	in	ADP
bptjm-38	139	27	gut	gut	NOUN
bptjm-38	139	28	microbiota	microbiota	NOUN
bptjm-38	139	29	.	.	PUNCT
bptjm-38	140	1	the	the	DET
bptjm-38	140	2	gut	gut	NOUN
bptjm-38	140	3	microbiome	microbiome	NOUN
bptjm-38	140	4	generates	generate	VERB
bptjm-38	140	5	a	a	DET
bptjm-38	140	6	large	large	ADJ
bptjm-38	140	7	portion	portion	NOUN
bptjm-38	140	8	of	of	ADP
bptjm-38	140	9	metabolites	metabolite	NOUN
bptjm-38	140	10	,	,	PUNCT
bptjm-38	140	11	and	and	CCONJ
bptjm-38	140	12	is	be	AUX
bptjm-38	140	13	responsible	responsible	ADJ
bptjm-38	140	14	for	for	ADP
bptjm-38	140	15	energy	energy	NOUN
bptjm-38	140	16	conversion	conversion	NOUN
bptjm-38	140	17	,	,	PUNCT
bptjm-38	140	18	signaling	signal	VERB
bptjm-38	140	19	,	,	PUNCT
bptjm-38	140	20	and	and	CCONJ
bptjm-38	140	21	,	,	PUNCT
bptjm-38	140	22	most	most	ADV
bptjm-38	140	23	importantly	importantly	ADV
bptjm-38	140	24	,	,	PUNCT
bptjm-38	140	25	epigenetic	epigenetic	ADJ
bptjm-38	140	26	signaling	signaling	NOUN
bptjm-38	140	27	.	.	PUNCT
bptjm-38	141	1	an	an	DET
bptjm-38	141	2	imbalanced	imbalanced	ADJ
bptjm-38	141	3	gut	gut	NOUN
bptjm-38	141	4	microbiome	microbiome	NOUN
bptjm-38	141	5	can	can	AUX
bptjm-38	141	6	create	create	VERB
bptjm-38	141	7	an	an	DET
bptjm-38	141	8	excess	excess	ADJ
bptjm-38	141	9	formation	formation	NOUN
bptjm-38	141	10	of	of	ADP
bptjm-38	141	11	s	s	NOUN
bptjm-38	141	12	-	-	PUNCT
bptjm-38	141	13	adenosyl	adenosyl	ADJ
bptjm-38	141	14	-	-	PUNCT
bptjm-38	141	15	methionine	methionine	NOUN
bptjm-38	141	16	,	,	PUNCT
bptjm-38	141	17	the	the	DET
bptjm-38	141	18	main	main	ADJ
bptjm-38	141	19	methyl	methyl	NOUN
bptjm-38	141	20	group	group	NOUN
bptjm-38	141	21	in	in	ADP
bptjm-38	141	22	a	a	DET
bptjm-38	141	23	microbiome	microbiome	NOUN
bptjm-38	141	24	,	,	PUNCT
bptjm-38	141	25	which	which	PRON
bptjm-38	141	26	results	result	VERB
bptjm-38	141	27	in	in	ADP
bptjm-38	141	28	increased	increased	ADJ
bptjm-38	141	29	methylation	methylation	NOUN
bptjm-38	141	30	.	.	PUNCT
bptjm-38	142	1	the	the	DET
bptjm-38	142	2	activation	activation	NOUN
bptjm-38	142	3	and	and	CCONJ
bptjm-38	142	4	deactivation	deactivation	NOUN
bptjm-38	142	5	of	of	ADP
bptjm-38	142	6	dna	dna	PROPN
bptjm-38	142	7	strands	strand	NOUN
bptjm-38	142	8	through	through	ADP
bptjm-38	142	9	dna	dna	PROPN
bptjm-38	142	10	methylation	methylation	NOUN
bptjm-38	142	11	could	could	AUX
bptjm-38	142	12	potentially	potentially	ADV
bptjm-38	142	13	lead	lead	VERB
bptjm-38	142	14	to	to	ADP
bptjm-38	142	15	the	the	DET
bptjm-38	142	16	gene	gene	NOUN
bptjm-38	142	17	impairment	impairment	NOUN
bptjm-38	142	18	/	/	SYM
bptjm-38	142	19	variation	variation	NOUN
bptjm-38	142	20	that	that	PRON
bptjm-38	142	21	results	result	VERB
bptjm-38	142	22	in	in	ADP
bptjm-38	142	23	asd	asd	PROPN
bptjm-38	142	24	.	.	PUNCT
bptjm-38	143	1	further	further	ADJ
bptjm-38	143	2	studies	study	NOUN
bptjm-38	143	3	into	into	ADP
bptjm-38	143	4	this	this	DET
bptjm-38	143	5	phenomenon	phenomenon	NOUN
bptjm-38	143	6	may	may	AUX
bptjm-38	143	7	have	have	VERB
bptjm-38	143	8	implications	implication	NOUN
bptjm-38	143	9	for	for	ADP
bptjm-38	143	10	treatment	treatment	NOUN
bptjm-38	143	11	development	development	NOUN
bptjm-38	143	12	if	if	SCONJ
bptjm-38	143	13	methylation	methylation	NOUN
bptjm-38	143	14	events	event	NOUN
bptjm-38	143	15	in	in	ADP
bptjm-38	143	16	�	�	PROPN
bptjm-38	143	17	uencing	uence	VERB
bptjm-38	143	18	asd	asd	PROPN
bptjm-38	143	19	development	development	NOUN
bptjm-38	143	20	can	can	AUX
bptjm-38	143	21	be	be	AUX
bptjm-38	143	22	targeted	target	VERB
bptjm-38	143	23	and	and	CCONJ
bptjm-38	143	24	altered	alter	VERB
bptjm-38	143	25	.	.	PUNCT
bptjm-38	144	1	future	future	ADJ
bptjm-38	144	2	research	research	NOUN
bptjm-38	144	3	studying	study	VERB
bptjm-38	144	4	the	the	DET
bptjm-38	144	5	gut	gut	NOUN
bptjm-38	144	6	microbiome	microbiome	NOUN
bptjm-38	144	7	’s	’s	PART
bptjm-38	144	8	ability	ability	NOUN
bptjm-38	144	9	to	to	PART
bptjm-38	144	10	interfere	interfere	VERB
bptjm-38	144	11	with	with	ADP
bptjm-38	144	12	methylation	methylation	NOUN
bptjm-38	144	13	patterns	pattern	NOUN
bptjm-38	144	14	can	can	AUX
bptjm-38	144	15	be	be	AUX
bptjm-38	144	16	used	use	VERB
bptjm-38	144	17	to	to	PART
bptjm-38	144	18	inform	inform	VERB
bptjm-38	144	19	development	development	NOUN
bptjm-38	144	20	of	of	ADP
bptjm-38	144	21	gene	gene	NOUN
bptjm-38	144	22	editing	edit	VERB
bptjm-38	144	23	in	in	ADP
bptjm-38	144	24	treating	treat	VERB
bptjm-38	144	25	asd	asd	NOUN
bptjm-38	144	26	pathogenesis	pathogenesis	NOUN
bptjm-38	144	27	.	.	PUNCT
bptjm-38	145	1	1	1	NUM
bptjm-38	145	2	conclusion	conclusion	NOUN
bptjm-38	145	3	while	while	SCONJ
bptjm-38	145	4	there	there	PRON
bptjm-38	145	5	is	be	VERB
bptjm-38	145	6	currently	currently	ADV
bptjm-38	145	7	no	no	DET
bptjm-38	145	8	cure	cure	NOUN
bptjm-38	145	9	for	for	ADP
bptjm-38	145	10	asd	asd	NOUN
bptjm-38	145	11	,	,	PUNCT
bptjm-38	145	12	there	there	PRON
bptjm-38	145	13	are	be	VERB
bptjm-38	145	14	various	various	ADJ
bptjm-38	145	15	approaches	approach	NOUN
bptjm-38	145	16	to	to	ADP
bptjm-38	145	17	managing	manage	VERB
bptjm-38	145	18	its	its	PRON
bptjm-38	145	19	symptoms	symptom	NOUN
bptjm-38	145	20	and	and	CCONJ
bptjm-38	145	21	improving	improve	VERB
bptjm-38	145	22	quality	quality	NOUN
bptjm-38	145	23	of	of	ADP
bptjm-38	145	24	life	life	NOUN
bptjm-38	145	25	.	.	PUNCT
bptjm-38	146	1	these	these	PRON
bptjm-38	146	2	include	include	VERB
bptjm-38	146	3	behavioral	behavioral	ADJ
bptjm-38	146	4	therapy	therapy	NOUN
bptjm-38	146	5	,	,	PUNCT
bptjm-38	146	6	medication	medication	NOUN
bptjm-38	146	7	,	,	PUNCT
bptjm-38	146	8	and	and	CCONJ
bptjm-38	146	9	support	support	NOUN
bptjm-38	146	10	services	service	NOUN
bptjm-38	146	11	.	.	PUNCT
bptjm-38	147	1	research	research	NOUN
bptjm-38	147	2	into	into	ADP
bptjm-38	147	3	the	the	DET
bptjm-38	147	4	causes	cause	NOUN
bptjm-38	147	5	and	and	CCONJ
bptjm-38	147	6	potential	potential	ADJ
bptjm-38	147	7	treatments	treatment	NOUN
bptjm-38	147	8	of	of	ADP
bptjm-38	147	9	asd	asd	NOUN
bptjm-38	147	10	is	be	AUX
bptjm-38	147	11	ongoing	ongoing	ADJ
bptjm-38	147	12	,	,	PUNCT
bptjm-38	147	13	and	and	CCONJ
bptjm-38	147	14	new	new	ADJ
bptjm-38	147	15	developments	development	NOUN
bptjm-38	147	16	are	be	AUX
bptjm-38	147	17	constantly	constantly	ADV
bptjm-38	147	18	emerging	emerge	VERB
bptjm-38	147	19	.	.	PUNCT
bptjm-38	148	1	2	2	NUM
bptjm-38	148	2	gene	gene	NOUN
bptjm-38	148	3	therapy	therapy	NOUN
bptjm-38	148	4	is	be	AUX
bptjm-38	148	5	one	one	NUM
bptjm-38	148	6	promising	promise	VERB
bptjm-38	148	7	approach	approach	NOUN
bptjm-38	148	8	that	that	PRON
bptjm-38	148	9	holds	hold	VERB
bptjm-38	148	10	signi	signi	PROPN
bptjm-38	148	11	�	�	NOUN
bptjm-38	148	12	cant	cant	VERB
bptjm-38	148	13	potential	potential	NOUN
bptjm-38	148	14	for	for	ADP
bptjm-38	148	15	treating	treat	VERB
bptjm-38	148	16	the	the	DET
bptjm-38	148	17	underlying	underlie	VERB
bptjm-38	148	18	causes	cause	NOUN
bptjm-38	148	19	of	of	ADP
bptjm-38	148	20	asd	asd	NOUN
bptjm-38	148	21	,	,	PUNCT
bptjm-38	148	22	rather	rather	ADV
bptjm-38	148	23	than	than	ADP
bptjm-38	148	24	just	just	ADV
bptjm-38	148	25	managing	manage	VERB
bptjm-38	148	26	its	its	PRON
bptjm-38	148	27	symptoms	symptom	NOUN
bptjm-38	148	28	.	.	PUNCT
bptjm-38	149	1	however	however	ADV
bptjm-38	149	2	,	,	PUNCT
bptjm-38	149	3	more	more	ADJ
bptjm-38	149	4	research	research	NOUN
bptjm-38	149	5	and	and	CCONJ
bptjm-38	149	6	clinical	clinical	ADJ
bptjm-38	149	7	trials	trial	NOUN
bptjm-38	149	8	are	be	AUX
bptjm-38	149	9	needed	need	VERB
bptjm-38	149	10	to	to	PART
bptjm-38	149	11	fully	fully	ADV
bptjm-38	149	12	understand	understand	VERB
bptjm-38	149	13	the	the	DET
bptjm-38	149	14	safety	safety	NOUN
bptjm-38	149	15	and	and	CCONJ
bptjm-38	149	16	e	e	NOUN
bptjm-38	149	17	�	�	PROPN
bptjm-38	149	18	ectiveness	ectiveness	NOUN
bptjm-38	149	19	of	of	ADP
bptjm-38	149	20	gene	gene	NOUN
bptjm-38	149	21	therapy	therapy	NOUN
bptjm-38	149	22	for	for	ADP
bptjm-38	149	23	asd	asd	NOUN
bptjm-38	149	24	.	.	PUNCT
bptjm-38	150	1	in	in	ADP
bptjm-38	150	2	the	the	DET
bptjm-38	150	3	last	last	ADJ
bptjm-38	150	4	berkeley	berkeley	PROPN
bptjm-38	150	5	pharma	pharma	PROPN
bptjm-38	150	6	tech	tech	NOUN
bptjm-38	150	7	journal	journal	NOUN
bptjm-38	150	8	of	of	ADP
bptjm-38	150	9	medicine	medicine	NOUN
bptjm-38	150	10	|	|	ADV
bptjm-38	150	11	22	22	NUM
bptjm-38	150	12	�	�	PROPN
bptjm-38	150	13	ve	ve	NOUN
bptjm-38	150	14	years	year	NOUN
bptjm-38	150	15	,	,	PUNCT
bptjm-38	150	16	clinical	clinical	ADJ
bptjm-38	150	17	research	research	NOUN
bptjm-38	150	18	has	have	AUX
bptjm-38	150	19	shown	show	VERB
bptjm-38	150	20	that	that	SCONJ
bptjm-38	150	21	tcf4	tcf4	PROPN
bptjm-38	150	22	,	,	PUNCT
bptjm-38	150	23	reln	reln	NOUN
bptjm-38	150	24	,	,	PUNCT
bptjm-38	150	25	and	and	CCONJ
bptjm-38	150	26	mecp2	mecp2	NOUN
bptjm-38	150	27	are	be	AUX
bptjm-38	150	28	linked	link	VERB
bptjm-38	150	29	to	to	ADP
bptjm-38	150	30	asd	asd	NOUN
bptjm-38	150	31	,	,	PUNCT
bptjm-38	150	32	providing	provide	VERB
bptjm-38	150	33	scientists	scientist	NOUN
bptjm-38	150	34	with	with	ADP
bptjm-38	150	35	a	a	DET
bptjm-38	150	36	basis	basis	NOUN
bptjm-38	150	37	to	to	PART
bptjm-38	150	38	explore	explore	VERB
bptjm-38	150	39	the	the	DET
bptjm-38	150	40	possibilities	possibility	NOUN
bptjm-38	150	41	of	of	ADP
bptjm-38	150	42	gene	gene	NOUN
bptjm-38	150	43	therapy	therapy	NOUN
bptjm-38	150	44	.	.	PUNCT
bptjm-38	151	1	the	the	DET
bptjm-38	151	2	crispr	crispr	ADJ
bptjm-38	151	3	strategy	strategy	NOUN
bptjm-38	151	4	and	and	CCONJ
bptjm-38	151	5	viral	viral	ADJ
bptjm-38	151	6	overexpression	overexpression	NOUN
bptjm-38	151	7	in	in	ADP
bptjm-38	151	8	relation	relation	NOUN
bptjm-38	151	9	to	to	ADP
bptjm-38	151	10	the	the	DET
bptjm-38	151	11	tcf4	tcf4	ADJ
bptjm-38	151	12	gene	gene	NOUN
bptjm-38	151	13	,	,	PUNCT
bptjm-38	151	14	mecp2	mecp2	NOUN
bptjm-38	151	15	levels	level	NOUN
bptjm-38	151	16	in	in	ADP
bptjm-38	151	17	relation	relation	NOUN
bptjm-38	151	18	to	to	ADP
bptjm-38	151	19	the	the	DET
bptjm-38	151	20	reln	reln	ADJ
bptjm-38	151	21	gene	gene	NOUN
bptjm-38	151	22	,	,	PUNCT
bptjm-38	151	23	and	and	CCONJ
bptjm-38	151	24	raav	raav	NOUN
bptjm-38	151	25	-	-	PUNCT
bptjm-38	151	26	delivered	deliver	VERB
bptjm-38	151	27	transgenes	transgene	NOUN
bptjm-38	151	28	to	to	PART
bptjm-38	151	29	alter	alter	VERB
bptjm-38	151	30	gene	gene	NOUN
bptjm-38	151	31	expression	expression	NOUN
bptjm-38	151	32	all	all	PRON
bptjm-38	151	33	show	show	VERB
bptjm-38	151	34	promise	promise	NOUN
bptjm-38	151	35	in	in	ADP
bptjm-38	151	36	altering	alter	VERB
bptjm-38	151	37	the	the	DET
bptjm-38	151	38	behavioral	behavioral	ADJ
bptjm-38	151	39	phenotypes	phenotype	NOUN
bptjm-38	151	40	associated	associate	VERB
bptjm-38	151	41	with	with	ADP
bptjm-38	151	42	autism	autism	NOUN
bptjm-38	151	43	spectrum	spectrum	NOUN
bptjm-38	151	44	disorder	disorder	NOUN
bptjm-38	151	45	.	.	PUNCT
bptjm-38	152	1	20	20	NUM
bptjm-38	152	2	however	however	ADV
bptjm-38	152	3	,	,	PUNCT
bptjm-38	152	4	there	there	PRON
bptjm-38	152	5	are	be	VERB
bptjm-38	152	6	also	also	ADV
bptjm-38	152	7	challenges	challenge	NOUN
bptjm-38	152	8	and	and	CCONJ
bptjm-38	152	9	limitations	limitation	NOUN
bptjm-38	152	10	to	to	ADP
bptjm-38	152	11	the	the	DET
bptjm-38	152	12	use	use	NOUN
bptjm-38	152	13	of	of	ADP
bptjm-38	152	14	gene	gene	NOUN
bptjm-38	152	15	therapy	therapy	NOUN
bptjm-38	152	16	for	for	ADP
bptjm-38	152	17	asd	asd	PROPN
bptjm-38	152	18	.	.	PUNCT
bptjm-38	153	1	gene	gene	NOUN
bptjm-38	153	2	therapy	therapy	NOUN
bptjm-38	153	3	is	be	AUX
bptjm-38	153	4	a	a	DET
bptjm-38	153	5	complex	complex	ADJ
bptjm-38	153	6	and	and	CCONJ
bptjm-38	153	7	expensive	expensive	ADJ
bptjm-38	153	8	approach	approach	NOUN
bptjm-38	153	9	that	that	PRON
bptjm-38	153	10	may	may	AUX
bptjm-38	153	11	not	not	PART
bptjm-38	153	12	be	be	AUX
bptjm-38	153	13	accessible	accessible	ADJ
bptjm-38	153	14	to	to	ADP
bptjm-38	153	15	all	all	DET
bptjm-38	153	16	individuals	individual	NOUN
bptjm-38	153	17	with	with	ADP
bptjm-38	153	18	asd	asd	PROPN
bptjm-38	153	19	.	.	PUNCT
bptjm-38	154	1	in	in	ADP
bptjm-38	154	2	addition	addition	NOUN
bptjm-38	154	3	,	,	PUNCT
bptjm-38	154	4	there	there	PRON
bptjm-38	154	5	are	be	VERB
bptjm-38	154	6	ethical	ethical	ADJ
bptjm-38	154	7	considerations	consideration	NOUN
bptjm-38	154	8	surrounding	surround	VERB
bptjm-38	154	9	the	the	DET
bptjm-38	154	10	use	use	NOUN
bptjm-38	154	11	of	of	ADP
bptjm-38	154	12	gene	gene	NOUN
bptjm-38	154	13	therapy	therapy	NOUN
bptjm-38	154	14	,	,	PUNCT
bptjm-38	154	15	such	such	ADJ
bptjm-38	154	16	as	as	ADP
bptjm-38	154	17	the	the	DET
bptjm-38	154	18	potential	potential	NOUN
bptjm-38	154	19	for	for	ADP
bptjm-38	154	20	unintended	unintended	ADJ
bptjm-38	154	21	e	e	NOUN
bptjm-38	154	22	�	�	NOUN
bptjm-38	154	23	ects	ect	VERB
bptjm-38	154	24	on	on	ADP
bptjm-38	154	25	other	other	ADJ
bptjm-38	154	26	genes	gene	NOUN
bptjm-38	154	27	.	.	PUNCT
bptjm-38	155	1	2	2	NUM
bptjm-38	155	2	overall	overall	ADJ
bptjm-38	155	3	,	,	PUNCT
bptjm-38	155	4	gene	gene	NOUN
bptjm-38	155	5	therapy	therapy	NOUN
bptjm-38	155	6	holds	hold	VERB
bptjm-38	155	7	signi	signi	PROPN
bptjm-38	155	8	�	�	NOUN
bptjm-38	155	9	cant	cant	VERB
bptjm-38	155	10	potential	potential	NOUN
bptjm-38	155	11	for	for	ADP
bptjm-38	155	12	the	the	DET
bptjm-38	155	13	treatment	treatment	NOUN
bptjm-38	155	14	of	of	ADP
bptjm-38	155	15	asd	asd	NOUN
bptjm-38	155	16	,	,	PUNCT
bptjm-38	155	17	but	but	CCONJ
bptjm-38	155	18	further	further	ADJ
bptjm-38	155	19	research	research	NOUN
bptjm-38	155	20	and	and	CCONJ
bptjm-38	155	21	clinical	clinical	ADJ
bptjm-38	155	22	trials	trial	NOUN
bptjm-38	155	23	are	be	AUX
bptjm-38	155	24	needed	need	VERB
bptjm-38	155	25	to	to	PART
bptjm-38	155	26	fully	fully	ADV
bptjm-38	155	27	understand	understand	VERB
bptjm-38	155	28	its	its	PRON
bptjm-38	155	29	safety	safety	NOUN
bptjm-38	155	30	and	and	CCONJ
bptjm-38	155	31	e	e	NOUN
bptjm-38	155	32	�	�	NOUN
bptjm-38	155	33	ectiveness	ectiveness	NOUN
bptjm-38	155	34	.	.	PUNCT
bptjm-38	156	1	if	if	SCONJ
bptjm-38	156	2	successful	successful	ADJ
bptjm-38	156	3	,	,	PUNCT
bptjm-38	156	4	gene	gene	NOUN
bptjm-38	156	5	therapy	therapy	NOUN
bptjm-38	156	6	could	could	AUX
bptjm-38	156	7	o	o	NOUN
bptjm-38	156	8	�	�	VERB
bptjm-38	156	9	er	er	INTJ
bptjm-38	156	10	a	a	DET
bptjm-38	156	11	promising	promising	ADJ
bptjm-38	156	12	new	new	ADJ
bptjm-38	156	13	approach	approach	NOUN
bptjm-38	156	14	for	for	ADP
bptjm-38	156	15	treating	treat	VERB
bptjm-38	156	16	the	the	DET
bptjm-38	156	17	underlying	underlie	VERB
bptjm-38	156	18	causes	cause	NOUN
bptjm-38	156	19	of	of	ADP
bptjm-38	156	20	asd	asd	NOUN
bptjm-38	156	21	and	and	CCONJ
bptjm-38	156	22	improving	improve	VERB
bptjm-38	156	23	the	the	DET
bptjm-38	156	24	lives	life	NOUN
bptjm-38	156	25	of	of	ADP
bptjm-38	156	26	individuals	individual	NOUN
bptjm-38	156	27	with	with	ADP
bptjm-38	156	28	the	the	DET
bptjm-38	156	29	condition	condition	NOUN
bptjm-38	156	30	.	.	PUNCT
bptjm-38	157	1	berkeley	berkeley	PROPN
bptjm-38	157	2	pharma	pharma	PROPN
bptjm-38	157	3	tech	tech	PROPN
bptjm-38	157	4	journal	journal	NOUN
bptjm-38	157	5	of	of	ADP
bptjm-38	157	6	medicine	medicine	NOUN
bptjm-38	157	7	|	|	ADV
bptjm-38	157	8	23	23	NUM
bptjm-38	157	9	references	reference	NOUN
bptjm-38	157	10	1	1	NUM
bptjm-38	157	11	.	.	PUNCT
bptjm-38	157	12	national	national	PROPN
bptjm-38	157	13	institute	institute	PROPN
bptjm-38	157	14	of	of	ADP
bptjm-38	157	15	mental	mental	ADJ
bptjm-38	157	16	health	health	NOUN
bptjm-38	157	17	.	.	PUNCT
bptjm-38	158	1	autism	autism	NOUN
bptjm-38	158	2	spectrum	spectrum	NOUN
bptjm-38	158	3	disorder	disorder	NOUN
bptjm-38	158	4	.	.	PUNCT
bptjm-38	159	1	www.nimh.nih.gov	www.nimh.nih.gov	VERB
bptjm-38	159	2	.	.	PUNCT
bptjm-38	160	1	published	publish	VERB
bptjm-38	160	2	march	march	PROPN
bptjm-38	160	3	2022	2022	NUM
bptjm-38	160	4	.	.	PUNCT
bptjm-38	161	1	https://www.nimh.nih.gov/health/topics/autism-spectr	https://www.nimh.nih.gov/health/topics/autism-spectr	PROPN
bptjm-38	161	2	um	um	INTJ
bptjm-38	161	3	-	-	PUNCT
bptjm-38	161	4	disorders	disorder	NOUN
bptjm-38	161	5	-	-	PUNCT
bptjm-38	161	6	asd	asd	NOUN
bptjm-38	161	7	2	2	NUM
bptjm-38	161	8	.	.	PUNCT
bptjm-38	161	9	american	american	PROPN
bptjm-38	161	10	psychiatric	psychiatric	PROPN
bptjm-38	161	11	association	association	PROPN
bptjm-38	161	12	.	.	PUNCT
bptjm-38	162	1	diagnostic	diagnostic	ADJ
bptjm-38	162	2	and	and	CCONJ
bptjm-38	162	3	statistical	statistical	ADJ
bptjm-38	162	4	manual	manual	NOUN
bptjm-38	162	5	of	of	ADP
bptjm-38	162	6	mental	mental	ADJ
bptjm-38	162	7	disorders	disorder	NOUN
bptjm-38	162	8	.	.	PUNCT
bptjm-38	163	1	5th	5th	ADJ
bptjm-38	163	2	ed	ed	NOUN
bptjm-38	163	3	.	.	PUNCT
bptjm-38	164	1	american	american	PROPN
bptjm-38	164	2	psychiatric	psychiatric	PROPN
bptjm-38	164	3	association	association	PROPN
bptjm-38	164	4	;	;	PUNCT
bptjm-38	164	5	2013	2013	NUM
bptjm-38	164	6	.	.	PUNCT
bptjm-38	165	1	3	3	X
bptjm-38	165	2	.	.	X
bptjm-38	165	3	ha	ha	PROPN
bptjm-38	166	1	s	s	PROPN
bptjm-38	166	2	,	,	PUNCT
bptjm-38	166	3	sohn	sohn	PROPN
bptjm-38	166	4	ij	ij	NOUN
bptjm-38	166	5	,	,	PUNCT
bptjm-38	166	6	kim	kim	PROPN
bptjm-38	166	7	n	n	CCONJ
bptjm-38	166	8	,	,	PUNCT
bptjm-38	166	9	sim	sim	ADJ
bptjm-38	166	10	hj	hj	PROPN
bptjm-38	166	11	,	,	PUNCT
bptjm-38	166	12	cheon	cheon	PROPN
bptjm-38	166	13	ka	ka	PROPN
bptjm-38	166	14	.	.	PROPN
bptjm-38	166	15	characteristics	characteristic	NOUN
bptjm-38	166	16	of	of	ADP
bptjm-38	166	17	brains	brain	NOUN
bptjm-38	166	18	in	in	ADP
bptjm-38	166	19	autism	autism	NOUN
bptjm-38	166	20	spectrum	spectrum	NOUN
bptjm-38	166	21	disorder	disorder	NOUN
bptjm-38	166	22	:	:	PUNCT
bptjm-38	166	23	structure	structure	NOUN
bptjm-38	166	24	,	,	PUNCT
bptjm-38	166	25	function	function	NOUN
bptjm-38	166	26	and	and	CCONJ
bptjm-38	166	27	connectivity	connectivity	NOUN
bptjm-38	166	28	across	across	ADP
bptjm-38	166	29	the	the	DET
bptjm-38	166	30	lifespan	lifespan	NOUN
bptjm-38	166	31	.	.	PUNCT
bptjm-38	167	1	experimental	experimental	ADJ
bptjm-38	167	2	neurobiology	neurobiology	NOUN
bptjm-38	167	3	.	.	PUNCT
bptjm-38	168	1	2015;24(4):273	2015;24(4):273	NUM
bptjm-38	168	2	.	.	PUNCT
bptjm-38	169	1	doi:10.5607	doi:10.5607	PROPN
bptjm-38	169	2	/	/	SYM
bptjm-38	169	3	en.2015.24.4.273	en.2015.24.4.273	PROPN
bptjm-38	169	4	4	4	X
bptjm-38	169	5	.	.	X
bptjm-38	169	6	autism	autism	NOUN
bptjm-38	169	7	spectrum	spectrum	NOUN
bptjm-38	169	8	disorder	disorder	NOUN
bptjm-38	169	9	fact	fact	NOUN
bptjm-38	169	10	sheet	sheet	NOUN
bptjm-38	169	11	|	|	PROPN
bptjm-38	169	12	national	national	PROPN
bptjm-38	169	13	institute	institute	PROPN
bptjm-38	169	14	of	of	ADP
bptjm-38	169	15	neurological	neurological	ADJ
bptjm-38	169	16	disorders	disorder	NOUN
bptjm-38	169	17	and	and	CCONJ
bptjm-38	169	18	stroke	stroke	NOUN
bptjm-38	169	19	.	.	PUNCT
bptjm-38	170	1	www.ninds.nih.gov	www.ninds.nih.gov	NOUN
bptjm-38	170	2	.	.	PUNCT
bptjm-38	171	1	published	publish	VERB
bptjm-38	171	2	july	july	PROPN
bptjm-38	171	3	25	25	NUM
bptjm-38	171	4	,	,	PUNCT
bptjm-38	171	5	2022	2022	NUM
bptjm-38	171	6	.	.	PUNCT
bptjm-38	172	1	https://www.ninds.nih.gov/autism-spectrum-disorder-fa	https://www.ninds.nih.gov/autism-spectrum-disorder-fa	PROPN
bptjm-38	173	1	ct	ct	PROPN
bptjm-38	173	2	-	-	PUNCT
bptjm-38	173	3	sheet	sheet	NOUN
bptjm-38	173	4	5	5	NUM
bptjm-38	173	5	.	.	PUNCT
bptjm-38	173	6	benger	benger	PROPN
bptjm-38	173	7	m	m	PROPN
bptjm-38	173	8	,	,	PUNCT
bptjm-38	173	9	kinali	kinali	PROPN
bptjm-38	173	10	m	m	PROPN
bptjm-38	173	11	,	,	PUNCT
bptjm-38	173	12	mazarakis	mazarakis	PROPN
bptjm-38	173	13	nd	nd	PROPN
bptjm-38	173	14	.	.	PROPN
bptjm-38	173	15	autism	autism	NOUN
bptjm-38	173	16	spectrum	spectrum	NOUN
bptjm-38	173	17	disorder	disorder	NOUN
bptjm-38	173	18	:	:	PUNCT
bptjm-38	173	19	prospects	prospect	NOUN
bptjm-38	173	20	for	for	ADP
bptjm-38	173	21	treatment	treatment	NOUN
bptjm-38	173	22	using	use	VERB
bptjm-38	173	23	gene	gene	NOUN
bptjm-38	173	24	therapy	therapy	NOUN
bptjm-38	173	25	.	.	PUNCT
bptjm-38	174	1	molecular	molecular	ADJ
bptjm-38	174	2	autism	autism	NOUN
bptjm-38	174	3	.	.	PUNCT
bptjm-38	175	1	2018;9(1	2018;9(1	NUM
bptjm-38	175	2	)	)	PUNCT
bptjm-38	175	3	.	.	PUNCT
bptjm-38	176	1	doi:10.1186	doi:10.1186	PROPN
bptjm-38	176	2	/	/	SYM
bptjm-38	176	3	s13229	s13229	NOUN
bptjm-38	176	4	-	-	PUNCT
bptjm-38	176	5	018	018	NUM
bptjm-38	176	6	-	-	PUNCT
bptjm-38	176	7	0222	0222	NUM
bptjm-38	176	8	-	-	SYM
bptjm-38	176	9	8	8	NUM
bptjm-38	176	10	6	6	NUM
bptjm-38	176	11	.	.	PUNCT
bptjm-38	177	1	alharthi	alharthi	PROPN
bptjm-38	177	2	a	a	DET
bptjm-38	177	3	,	,	PUNCT
bptjm-38	177	4	alhazmi	alhazmi	PROPN
bptjm-38	177	5	s	s	PART
bptjm-38	177	6	,	,	PUNCT
bptjm-38	177	7	alburae	alburae	NOUN
bptjm-38	177	8	n	n	CCONJ
bptjm-38	177	9	,	,	PUNCT
bptjm-38	178	1	bahieldin	bahieldin	VERB
bptjm-38	178	2	a.	a.	NOUN
bptjm-38	178	3	the	the	DET
bptjm-38	178	4	human	human	ADJ
bptjm-38	178	5	gut	gut	NOUN
bptjm-38	178	6	microbiome	microbiome	NOUN
bptjm-38	178	7	as	as	ADP
bptjm-38	178	8	a	a	DET
bptjm-38	178	9	potential	potential	ADJ
bptjm-38	178	10	factor	factor	NOUN
bptjm-38	178	11	in	in	ADP
bptjm-38	178	12	autism	autism	NOUN
bptjm-38	178	13	spectrum	spectrum	NOUN
bptjm-38	178	14	disorder	disorder	NOUN
bptjm-38	178	15	.	.	PUNCT
bptjm-38	179	1	international	international	ADJ
bptjm-38	179	2	journal	journal	NOUN
bptjm-38	179	3	of	of	ADP
bptjm-38	179	4	molecular	molecular	ADJ
bptjm-38	179	5	sciences	science	NOUN
bptjm-38	179	6	.	.	PUNCT
bptjm-38	180	1	2022;23(3):1363	2022;23(3):1363	X
bptjm-38	180	2	.	.	PUNCT
bptjm-38	181	1	doi:10.3390	doi:10.3390	NOUN
bptjm-38	181	2	/	/	SYM
bptjm-38	181	3	ijms2303136	ijms2303136	PROPN
bptjm-38	181	4	7	7	NUM
bptjm-38	181	5	.	.	PUNCT
bptjm-38	182	1	capra	capra	PROPN
bptjm-38	182	2	e	e	PROPN
bptjm-38	182	3	,	,	PUNCT
bptjm-38	182	4	godfrey	godfrey	PROPN
bptjm-38	182	5	a	a	NOUN
bptjm-38	182	6	,	,	PUNCT
bptjm-38	182	7	loche	loche	PROPN
bptjm-38	182	8	a	a	X
bptjm-38	182	9	,	,	PUNCT
bptjm-38	182	10	smith	smith	PROPN
bptjm-38	182	11	j.	j.	PROPN
bptjm-38	182	12	innovation	innovation	PROPN
bptjm-38	182	13	in	in	ADP
bptjm-38	182	14	viral	viral	ADJ
bptjm-38	182	15	-	-	PUNCT
bptjm-38	182	16	vector	vector	NOUN
bptjm-38	182	17	gene	gene	NOUN
bptjm-38	182	18	therapy	therapy	NOUN
bptjm-38	182	19	:	:	PUNCT
bptjm-38	182	20	unlocking	unlock	VERB
bptjm-38	182	21	the	the	DET
bptjm-38	182	22	promise	promise	NOUN
bptjm-38	182	23	|	|	ADV
bptjm-38	182	24	mckinsey	mckinsey	NOUN
bptjm-38	182	25	.	.	PUNCT
bptjm-38	183	1	www.mckinsey.com	www.mckinsey.com	X
bptjm-38	183	2	.	.	PROPN
bptjm-38	184	1	published	publish	VERB
bptjm-38	184	2	may	may	PROPN
bptjm-38	184	3	17	17	NUM
bptjm-38	184	4	,	,	PUNCT
bptjm-38	184	5	2021	2021	NUM
bptjm-38	184	6	.	.	PUNCT
bptjm-38	185	1	https://www.mckinsey.com/industries/life-sciences/our	https://www.mckinsey.com/industries/life-sciences/our	PRON
bptjm-38	185	2	insights	insight	NOUN
bptjm-38	185	3	/	/	SYM
bptjm-38	185	4	gene	gene	NOUN
bptjm-38	185	5	-	-	PUNCT
bptjm-38	185	6	therapy	therapy	NOUN
bptjm-38	185	7	-	-	PUNCT
bptjm-38	185	8	innovationunlocking	innovationunlocke	VERB
bptjm-38	185	9	-	-	PUNCT
bptjm-38	185	10	the	the	DET
bptjm-38	185	11	-	-	PUNCT
bptjm-38	185	12	promise	promise	NOUN
bptjm-38	185	13	-of	-of	ADJ
bptjm-38	185	14	-	-	PUNCT
bptjm-38	185	15	viral	viral	ADJ
bptjm-38	185	16	-	-	PUNCT
bptjm-38	185	17	vectors	vector	NOUN
bptjm-38	185	18	8	8	NUM
bptjm-38	185	19	.	.	PUNCT
bptjm-38	185	20	singer	singer	NOUN
bptjm-38	185	21	e.	e.	PROPN
bptjm-38	185	22	finding	find	VERB
bptjm-38	185	23	new	new	ADJ
bptjm-38	185	24	treatments	treatment	NOUN
bptjm-38	185	25	for	for	ADP
bptjm-38	185	26	autism	autism	NOUN
bptjm-38	185	27	.	.	PUNCT
bptjm-38	186	1	spark	spark	NOUN
bptjm-38	186	2	for	for	ADP
bptjm-38	186	3	autism	autism	NOUN
bptjm-38	186	4	.	.	PUNCT
bptjm-38	187	1	published	publish	VERB
bptjm-38	187	2	august	august	PROPN
bptjm-38	187	3	25	25	NUM
bptjm-38	187	4	,	,	PUNCT
bptjm-38	187	5	2017	2017	NUM
bptjm-38	187	6	.	.	PUNCT
bptjm-38	188	1	https://sparkforautism.org/discover_article/�nding-new	https://sparkforautism.org/discover_article/�nding-new	ADJ
bptjm-38	188	2	-treatments	-treatment	NOUN
bptjm-38	188	3	-	-	PUNCT
bptjm-38	188	4	for	for	ADP
bptjm-38	188	5	-	-	PUNCT
bptjm-38	188	6	autism/	autism/	NUM
bptjm-38	188	7	9	9	NUM
bptjm-38	188	8	.	.	PUNCT
bptjm-38	188	9	yenkoyan	yenkoyan	PROPN
bptjm-38	189	1	k	k	PROPN
bptjm-38	189	2	,	,	PUNCT
bptjm-38	189	3	grigoryan	grigoryan	X
bptjm-38	189	4	a	a	PRON
bptjm-38	189	5	,	,	PUNCT
bptjm-38	189	6	fereshetyan	fereshetyan	NOUN
bptjm-38	190	1	k	k	PROPN
bptjm-38	190	2	,	,	PUNCT
bptjm-38	190	3	yepremyan	yepremyan	PROPN
bptjm-38	190	4	d.	d.	PROPN
bptjm-38	190	5	advances	advance	VERB
bptjm-38	190	6	in	in	ADP
bptjm-38	190	7	understanding	understand	VERB
bptjm-38	190	8	the	the	DET
bptjm-38	190	9	pathophysiology	pathophysiology	NOUN
bptjm-38	190	10	of	of	ADP
bptjm-38	190	11	autism	autism	NOUN
bptjm-38	190	12	spectrum	spectrum	NOUN
bptjm-38	190	13	disorders	disorder	NOUN
bptjm-38	190	14	.	.	PUNCT
bptjm-38	191	1	behavioural	behavioural	ADJ
bptjm-38	191	2	brain	brain	NOUN
bptjm-38	191	3	research	research	NOUN
bptjm-38	191	4	.	.	PUNCT
bptjm-38	192	1	2017;331(0166	2017;331(0166	NUM
bptjm-38	192	2	-	-	SYM
bptjm-38	192	3	4328):92	4328):92	NUM
bptjm-38	192	4	-	-	PUNCT
bptjm-38	192	5	101	101	NUM
bptjm-38	192	6	.	.	PUNCT
bptjm-38	193	1	doi:10.1016	doi:10.1016	PROPN
bptjm-38	193	2	/	/	SYM
bptjm-38	193	3	j.bbr.2017.04.038	j.bbr.2017.04.038	PROPN
bptjm-38	193	4	10	10	NUM
bptjm-38	193	5	.	.	PUNCT
bptjm-38	194	1	mlynaryk	mlynaryk	ADJ
bptjm-38	194	2	n.	n.	PROPN
bptjm-38	194	3	gene	gene	NOUN
bptjm-38	194	4	therapy	therapy	NOUN
bptjm-38	194	5	reverses	reverse	VERB
bptjm-38	194	6	e	e	NOUN
bptjm-38	194	7	�	�	NOUN
bptjm-38	194	8	ects	ect	NOUN
bptjm-38	194	9	of	of	ADP
bptjm-38	194	10	autism	autism	NOUN
bptjm-38	194	11	-	-	PUNCT
bptjm-38	194	12	linked	link	VERB
bptjm-38	194	13	mutation	mutation	NOUN
bptjm-38	194	14	in	in	ADP
bptjm-38	194	15	brain	brain	NOUN
bptjm-38	194	16	organoids	organoid	NOUN
bptjm-38	194	17	.	.	PUNCT
bptjm-38	195	1	today.ucsd.edu	today.ucsd.edu	PROPN
bptjm-38	195	2	.	.	PUNCT
bptjm-38	196	1	published	publish	VERB
bptjm-38	196	2	may	may	AUX
bptjm-38	196	3	22	22	NUM
bptjm-38	196	4	,	,	PUNCT
bptjm-38	196	5	2002	2002	NUM
bptjm-38	196	6	.	.	PUNCT
bptjm-38	197	1	https://today.ucsd.edu/story/gene-therapy-reverses-e�ec	https://today.ucsd.edu/story/gene-therapy-reverses-e�ec	PROPN
bptjm-38	197	2	ts	ts	PROPN
bptjm-38	197	3	-	-	PUNCT
bptjm-38	197	4	of	of	ADP
bptjm-38	197	5	-	-	PUNCT
bptjm-38	197	6	autism	autism	NOUN
bptjm-38	197	7	-	-	PUNCT
bptjm-38	197	8	linked	link	VERB
bptjm-38	197	9	-	-	PUNCT
bptjm-38	197	10	mutation	mutation	NOUN
bptjm-38	197	11	-	-	PUNCT
bptjm-38	197	12	in	in	ADP
bptjm-38	197	13	-	-	PUNCT
bptjm-38	197	14	b	b	NOUN
bptjm-38	197	15	rain	rain	NOUN
bptjm-38	197	16	-	-	PUNCT
bptjm-38	197	17	organoids	organoid	NOUN
bptjm-38	197	18	11	11	NUM
bptjm-38	197	19	.	.	PUNCT
bptjm-38	198	1	papes	pape	NOUN
bptjm-38	198	2	f	f	PROPN
bptjm-38	198	3	,	,	PUNCT
bptjm-38	198	4	camargo	camargo	PROPN
bptjm-38	198	5	ap	ap	PROPN
bptjm-38	198	6	,	,	PUNCT
bptjm-38	198	7	de	de	PROPN
bptjm-38	198	8	souza	souza	PROPN
bptjm-38	198	9	js	js	PROPN
bptjm-38	198	10	,	,	PUNCT
bptjm-38	198	11	et	et	PROPN
bptjm-38	198	12	al	al	PROPN
bptjm-38	198	13	.	.	PUNCT
bptjm-38	198	14	transcription	transcription	NOUN
bptjm-38	198	15	factor	factor	NOUN
bptjm-38	198	16	4	4	NUM
bptjm-38	198	17	loss	loss	NOUN
bptjm-38	198	18	-	-	PUNCT
bptjm-38	198	19	of	of	ADP
bptjm-38	198	20	-	-	PUNCT
bptjm-38	198	21	function	function	NOUN
bptjm-38	198	22	is	be	AUX
bptjm-38	198	23	associated	associate	VERB
bptjm-38	198	24	with	with	ADP
bptjm-38	198	25	de	de	PROPN
bptjm-38	198	26	�	�	PROPN
bptjm-38	198	27	cits	cit	NOUN
bptjm-38	198	28	in	in	ADP
bptjm-38	198	29	progenitor	progenitor	NOUN
bptjm-38	198	30	proliferation	proliferation	NOUN
bptjm-38	198	31	and	and	CCONJ
bptjm-38	198	32	cortical	cortical	ADJ
bptjm-38	198	33	neuron	neuron	NOUN
bptjm-38	198	34	content	content	NOUN
bptjm-38	198	35	.	.	PUNCT
bptjm-38	199	1	nature	nature	NOUN
bptjm-38	199	2	communications	communication	NOUN
bptjm-38	199	3	.	.	PUNCT
bptjm-38	200	1	2022;13(1):2387	2022;13(1):2387	X
bptjm-38	200	2	.	.	PUNCT
bptjm-38	200	3	doi:10.1038	doi:10.1038	NOUN
bptjm-38	200	4	/	/	SYM
bptjm-38	200	5	s41467	s41467	NOUN
bptjm-38	200	6	-	-	PUNCT
bptjm-38	200	7	022	022	NUM
bptjm-38	200	8	-	-	PUNCT
bptjm-38	200	9	29942	29942	NUM
bptjm-38	200	10	-	-	SYM
bptjm-38	200	11	w	w	NOUN
bptjm-38	200	12	12	12	NUM
bptjm-38	200	13	.	.	PUNCT
bptjm-38	201	1	bioinforx	bioinforx	PROPN
bptjm-38	201	2	.	.	PUNCT
bptjm-38	202	1	products	product	NOUN
bptjm-38	202	2	.	.	PUNCT
bptjm-38	203	1	alstem	alstem	NOUN
bptjm-38	203	2	.	.	PUNCT
bptjm-38	204	1	accessed	access	VERB
bptjm-38	204	2	december	december	PROPN
bptjm-38	204	3	10	10	NUM
bptjm-38	204	4	,	,	PUNCT
bptjm-38	204	5	2022	2022	NUM
bptjm-38	204	6	.	.	PUNCT
bptjm-38	205	1	https://www.alstembio.com/web/product_list.php?cate	https://www.alstembio.com/web/product_list.php?cate	PROPN
bptjm-38	205	2	gory	gory	NOUN
bptjm-38	205	3	=	=	SYM
bptjm-38	205	4	human_ips_cell_lines	human_ips_cell_line	NOUN
bptjm-38	205	5	.	.	NOUN
bptjm-38	205	6	13	13	NUM
bptjm-38	205	7	.	.	PUNCT
bptjm-38	206	1	lópez	lópez	PROPN
bptjm-38	206	2	-	-	PUNCT
bptjm-38	206	3	bendito	bendito	PROPN
bptjm-38	206	4	g	g	PROPN
bptjm-38	206	5	,	,	PUNCT
bptjm-38	206	6	cautinat	cautinat	NOUN
bptjm-38	206	7	a	a	PRON
bptjm-38	206	8	,	,	PUNCT
bptjm-38	206	9	sánchez	sánchez	PROPN
bptjm-38	206	10	ja	ja	PROPN
bptjm-38	206	11	,	,	PUNCT
bptjm-38	206	12	et	et	PROPN
bptjm-38	206	13	al	al	PROPN
bptjm-38	206	14	.	.	PROPN
bptjm-38	207	1	tangential	tangential	ADJ
bptjm-38	207	2	neuronal	neuronal	ADJ
bptjm-38	207	3	migration	migration	NOUN
bptjm-38	207	4	controls	control	VERB
bptjm-38	207	5	axon	axon	NOUN
bptjm-38	207	6	guidance	guidance	NOUN
bptjm-38	207	7	:	:	PUNCT
bptjm-38	207	8	a	a	DET
bptjm-38	207	9	role	role	NOUN
bptjm-38	207	10	for	for	ADP
bptjm-38	207	11	neuregulin-1	neuregulin-1	PRON
bptjm-38	207	12	in	in	ADP
bptjm-38	207	13	thalamocortical	thalamocortical	ADJ
bptjm-38	207	14	axon	axon	NOUN
bptjm-38	207	15	navigation	navigation	NOUN
bptjm-38	207	16	.	.	PUNCT
bptjm-38	208	1	cell	cell	NOUN
bptjm-38	208	2	.	.	PUNCT
bptjm-38	209	1	14	14	NUM
bptjm-38	209	2	.	.	PUNCT
bptjm-38	210	1	frotscher	frotscher	PROPN
bptjm-38	210	2	m	m	PROPN
bptjm-38	210	3	,	,	PUNCT
bptjm-38	210	4	chai	chai	NOUN
bptjm-38	210	5	x	x	NOUN
bptjm-38	210	6	,	,	PUNCT
bptjm-38	210	7	bock	bock	NOUN
bptjm-38	210	8	hh	hh	PROPN
bptjm-38	210	9	,	,	PUNCT
bptjm-38	210	10	haas	haas	PROPN
bptjm-38	210	11	ca	ca	PROPN
bptjm-38	210	12	,	,	PUNCT
bptjm-38	210	13	förster	förster	NOUN
bptjm-38	210	14	e	e	NOUN
bptjm-38	210	15	,	,	PUNCT
bptjm-38	210	16	zhao	zhao	PROPN
bptjm-38	210	17	s.	s.	PROPN
bptjm-38	210	18	role	role	NOUN
bptjm-38	210	19	of	of	ADP
bptjm-38	210	20	reelin	reelin	PROPN
bptjm-38	210	21	in	in	ADP
bptjm-38	210	22	the	the	DET
bptjm-38	210	23	development	development	NOUN
bptjm-38	210	24	and	and	CCONJ
bptjm-38	210	25	maintenance	maintenance	NOUN
bptjm-38	210	26	of	of	ADP
bptjm-38	210	27	cortical	cortical	ADJ
bptjm-38	210	28	lamination	lamination	NOUN
bptjm-38	210	29	.	.	PUNCT
bptjm-38	211	1	j	j	PROPN
bptjm-38	211	2	neural	neural	ADJ
bptjm-38	211	3	transm	transm	PROPN
bptjm-38	211	4	(	(	PUNCT
bptjm-38	211	5	vienna	vienna	PROPN
bptjm-38	211	6	)	)	PUNCT
bptjm-38	211	7	.	.	PUNCT
bptjm-38	212	1	2009;116(11):1451	2009;116(11):1451	NUM
bptjm-38	212	2	-	-	SYM
bptjm-38	212	3	1455	1455	NUM
bptjm-38	212	4	.	.	PUNCT
bptjm-38	213	1	doi:10.1007	doi:10.1007	VERB
bptjm-38	213	2	/	/	SYM
bptjm-38	213	3	s00702	s00702	NOUN
bptjm-38	213	4	-	-	PUNCT
bptjm-38	213	5	009	009	NUM
bptjm-38	213	6	-	-	PUNCT
bptjm-38	213	7	0228	0228	NUM
bptjm-38	213	8	-	-	PUNCT
bptjm-38	213	9	7	7	NUM
bptjm-38	213	10	15	15	NUM
bptjm-38	213	11	.	.	PUNCT
bptjm-38	214	1	zhubi	zhubi	PROPN
bptjm-38	214	2	a	a	PRON
bptjm-38	214	3	,	,	PUNCT
bptjm-38	214	4	cook	cook	VERB
bptjm-38	214	5	eh	eh	INTJ
bptjm-38	214	6	,	,	PUNCT
bptjm-38	214	7	guidotti	guidotti	NOUN
bptjm-38	214	8	a	a	DET
bptjm-38	214	9	,	,	PUNCT
bptjm-38	214	10	grayson	grayson	PROPN
bptjm-38	214	11	dr	dr	PROPN
bptjm-38	214	12	.	.	PROPN
bptjm-38	214	13	chapter	chapter	PROPN
bptjm-38	214	14	six	six	NUM
bptjm-38	214	15	epigenetic	epigenetic	ADJ
bptjm-38	214	16	mechanisms	mechanism	NOUN
bptjm-38	214	17	in	in	ADP
bptjm-38	214	18	autism	autism	NOUN
bptjm-38	214	19	spectrum	spectrum	NOUN
bptjm-38	214	20	disorder	disorder	NOUN
bptjm-38	214	21	.	.	PUNCT
bptjm-38	215	1	sciencedirect	sciencedirect	PROPN
bptjm-38	215	2	.	.	PUNCT
bptjm-38	216	1	published	publish	VERB
bptjm-38	216	2	january	january	PROPN
bptjm-38	216	3	1	1	NUM
bptjm-38	216	4	,	,	PUNCT
bptjm-38	216	5	2014	2014	NUM
bptjm-38	216	6	.	.	PUNCT
bptjm-38	217	1	berkeley	berkeley	PROPN
bptjm-38	217	2	pharma	pharma	PROPN
bptjm-38	217	3	tech	tech	PROPN
bptjm-38	217	4	journal	journal	NOUN
bptjm-38	217	5	of	of	ADP
bptjm-38	217	6	medicine	medicine	NOUN
bptjm-38	217	7	|	|	ADV
bptjm-38	217	8	24	24	NUM
bptjm-38	217	9	https://www.sciencedirect.com/science/article/pii/b978	https://www.sciencedirect.com/science/article/pii/b978	NOUN
bptjm-38	217	10	0128013113000068?via%3dihub	0128013113000068?via%3dihub	NUM
bptjm-38	217	11	16	16	NUM
bptjm-38	217	12	.	.	PUNCT
bptjm-38	218	1	lammert	lammert	PROPN
bptjm-38	218	2	db	db	PROPN
bptjm-38	218	3	,	,	PUNCT
bptjm-38	218	4	howell	howell	PROPN
bptjm-38	218	5	bw	bw	PROPN
bptjm-38	218	6	.	.	PUNCT
bptjm-38	219	1	reln	reln	PROPN
bptjm-38	219	2	mutations	mutation	NOUN
bptjm-38	219	3	in	in	ADP
bptjm-38	219	4	autism	autism	NOUN
bptjm-38	219	5	spectrum	spectrum	NOUN
bptjm-38	219	6	disorder	disorder	NOUN
bptjm-38	219	7	.	.	PUNCT
bptjm-38	220	1	front	front	ADJ
bptjm-38	220	2	cell	cell	NOUN
bptjm-38	220	3	neurosci	neurosci	NOUN
bptjm-38	220	4	.	.	PUNCT
bptjm-38	221	1	2016;10:84	2016;10:84	NOUN
bptjm-38	221	2	.	.	PUNCT
bptjm-38	222	1	doi:10.3389	doi:10.3389	PROPN
bptjm-38	222	2	/	/	SYM
bptjm-38	222	3	fncel.2016.0008	fncel.2016.0008	PROPN
bptjm-38	222	4	17	17	NUM
bptjm-38	222	5	.	.	PUNCT
bptjm-38	223	1	ehrhart	ehrhart	PROPN
bptjm-38	223	2	f	f	PROPN
bptjm-38	223	3	,	,	PUNCT
bptjm-38	223	4	coort	coort	PROPN
bptjm-38	223	5	slm	slm	PROPN
bptjm-38	223	6	,	,	PUNCT
bptjm-38	223	7	cirillo	cirillo	PROPN
bptjm-38	223	8	e	e	PROPN
bptjm-38	223	9	,	,	PUNCT
bptjm-38	223	10	smeets	smeet	NOUN
bptjm-38	223	11	e	e	NOUN
bptjm-38	223	12	,	,	PUNCT
bptjm-38	223	13	evelo	evelo	NOUN
bptjm-38	223	14	ct	ct	PRON
bptjm-38	223	15	,	,	PUNCT
bptjm-38	223	16	curfs	curfs	PROPN
bptjm-38	223	17	lmg	lmg	PROPN
bptjm-38	223	18	.	.	PROPN
bptjm-38	224	1	rett	rett	PROPN
bptjm-38	224	2	syndrome	syndrome	PROPN
bptjm-38	224	3	–	–	PUNCT
bptjm-38	224	4	biological	biological	ADJ
bptjm-38	224	5	pathways	pathway	NOUN
bptjm-38	224	6	leading	lead	VERB
bptjm-38	224	7	from	from	ADP
bptjm-38	224	8	mecp2	mecp2	NOUN
bptjm-38	224	9	to	to	ADP
bptjm-38	224	10	disorder	disorder	NOUN
bptjm-38	224	11	phenotypes	phenotype	NOUN
bptjm-38	224	12	.	.	PUNCT
bptjm-38	225	1	orphanet	orphanet	PROPN
bptjm-38	225	2	journal	journal	PROPN
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bptjm-38	225	4	rare	rare	ADJ
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bptjm-38	225	6	.	.	PUNCT
bptjm-38	226	1	2016;11(1	2016;11(1	NUM
bptjm-38	226	2	)	)	PUNCT
bptjm-38	226	3	.	.	PUNCT
bptjm-38	227	1	doi:10.1186	doi:10.1186	PROPN
bptjm-38	227	2	/	/	SYM
bptjm-38	227	3	s13023	s13023	NOUN
bptjm-38	227	4	-	-	PUNCT
bptjm-38	227	5	016	016	NUM
bptjm-38	227	6	-	-	PUNCT
bptjm-38	227	7	0545	0545	NUM
bptjm-38	227	8	-	-	SYM
bptjm-38	227	9	5	5	NUM
bptjm-38	227	10	18	18	NUM
bptjm-38	227	11	.	.	PUNCT
bptjm-38	228	1	wen	wen	PROPN
bptjm-38	228	2	z	z	PROPN
bptjm-38	228	3	,	,	PUNCT
bptjm-38	228	4	cheng	cheng	PROPN
bptjm-38	228	5	tl	tl	PROPN
bptjm-38	228	6	,	,	PUNCT
bptjm-38	228	7	li	li	PROPN
bptjm-38	228	8	g	g	PROPN
bptjm-38	228	9	,	,	PUNCT
bptjm-38	228	10	et	et	PROPN
bptjm-38	228	11	al	al	PROPN
bptjm-38	228	12	.	.	PUNCT
bptjm-38	228	13	identi	identi	PROPN
bptjm-38	228	14	�	�	PROPN
bptjm-38	228	15	cation	cation	NOUN
bptjm-38	228	16	of	of	ADP
bptjm-38	228	17	autism	autism	NOUN
bptjm-38	228	18	-	-	PUNCT
bptjm-38	228	19	related	relate	VERB
bptjm-38	228	20	mecp2	mecp2	NOUN
bptjm-38	228	21	mutations	mutation	NOUN
bptjm-38	228	22	by	by	ADP
bptjm-38	228	23	whole	whole	ADJ
bptjm-38	228	24	-	-	PUNCT
bptjm-38	228	25	exome	exome	NOUN
bptjm-38	228	26	sequencing	sequencing	NOUN
bptjm-38	228	27	and	and	CCONJ
bptjm-38	228	28	functional	functional	ADJ
bptjm-38	228	29	validation	validation	NOUN
bptjm-38	228	30	.	.	PUNCT
bptjm-38	229	1	molecular	molecular	ADJ
bptjm-38	229	2	autism	autism	NOUN
bptjm-38	229	3	.	.	PUNCT
bptjm-38	230	1	2017;8(1	2017;8(1	NUM
bptjm-38	230	2	)	)	PUNCT
bptjm-38	230	3	.	.	PUNCT
bptjm-38	231	1	doi:10.1186	doi:10.1186	PROPN
bptjm-38	231	2	/	/	SYM
bptjm-38	231	3	s13229	s13229	NOUN
bptjm-38	231	4	-	-	PUNCT
bptjm-38	231	5	017	017	NUM
bptjm-38	231	6	-	-	PUNCT
bptjm-38	231	7	0157	0157	NUM
bptjm-38	231	8	-	-	SYM
bptjm-38	231	9	5	5	NUM
bptjm-38	231	10	19	19	NUM
bptjm-38	231	11	.	.	PUNCT
bptjm-38	232	1	sztainberg	sztainberg	PROPN
bptjm-38	232	2	y	y	PROPN
bptjm-38	232	3	,	,	PUNCT
bptjm-38	232	4	chen	chen	PROPN
bptjm-38	232	5	h	h	PROPN
bptjm-38	232	6	,	,	PUNCT
bptjm-38	232	7	swann	swann	PROPN
bptjm-38	232	8	jw	jw	PROPN
bptjm-38	232	9	,	,	PUNCT
bptjm-38	232	10	et	et	PROPN
bptjm-38	232	11	al	al	PROPN
bptjm-38	232	12	.	.	PROPN
bptjm-38	232	13	reversal	reversal	NOUN
bptjm-38	232	14	of	of	ADP
bptjm-38	232	15	phenotypes	phenotype	NOUN
bptjm-38	232	16	in	in	ADP
bptjm-38	232	17	mecp2	mecp2	NOUN
bptjm-38	232	18	duplication	duplication	NOUN
bptjm-38	232	19	mice	mouse	NOUN
bptjm-38	232	20	using	use	VERB
bptjm-38	232	21	genetic	genetic	ADJ
bptjm-38	232	22	rescue	rescue	NOUN
bptjm-38	232	23	or	or	CCONJ
bptjm-38	232	24	antisense	antisense	NOUN
bptjm-38	232	25	oligonucleotides	oligonucleotide	NOUN
bptjm-38	232	26	.	.	PUNCT
bptjm-38	233	1	nature	nature	NOUN
bptjm-38	233	2	.	.	PUNCT
bptjm-38	234	1	2015;528(7580):123	2015;528(7580):123	NUM
bptjm-38	234	2	-	-	SYM
bptjm-38	234	3	126	126	NUM
bptjm-38	234	4	.	.	PUNCT
bptjm-38	235	1	doi:10.1038	doi:10.1038	NOUN
bptjm-38	235	2	/	/	SYM
bptjm-38	235	3	nature16159	nature16159	PROPN
bptjm-38	235	4	20	20	NUM
bptjm-38	235	5	.	.	PUNCT
bptjm-38	236	1	kaufmann	kaufmann	PROPN
bptjm-38	236	2	we	we	PRON
bptjm-38	236	3	,	,	PUNCT
bptjm-38	236	4	kidd	kidd	PROPN
bptjm-38	236	5	sa	sa	PROPN
bptjm-38	236	6	,	,	PUNCT
bptjm-38	236	7	andrews	andrews	PROPN
bptjm-38	236	8	hf	hf	PROPN
bptjm-38	236	9	,	,	PUNCT
bptjm-38	236	10	et	et	PROPN
bptjm-38	236	11	al	al	PROPN
bptjm-38	236	12	.	.	PROPN
bptjm-38	237	1	autism	autism	NOUN
bptjm-38	237	2	spectrum	spectrum	NOUN
bptjm-38	237	3	disorder	disorder	NOUN
bptjm-38	237	4	in	in	ADP
bptjm-38	237	5	fragile	fragile	ADJ
bptjm-38	237	6	x	x	ADJ
bptjm-38	237	7	syndrome	syndrome	NOUN
bptjm-38	237	8	:	:	PUNCT
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bptjm-38	237	10	conditions	condition	NOUN
bptjm-38	237	11	and	and	CCONJ
bptjm-38	237	12	current	current	ADJ
bptjm-38	237	13	treatment	treatment	NOUN
bptjm-38	237	14	.	.	PUNCT
bptjm-38	238	1	pediatrics	pediatric	NOUN
bptjm-38	238	2	.	.	PUNCT
bptjm-38	239	1	2017;139(supplement	2017;139(supplement	NUM
bptjm-38	239	2	3):s194	3):s194	NUM
bptjm-38	239	3	-	-	SYM
bptjm-38	239	4	s206	s206	PROPN
bptjm-38	239	5	.	.	PUNCT
bptjm-38	239	6	doi:10.1542	doi:10.1542	PROPN
bptjm-38	239	7	/	/	SYM
bptjm-38	240	1	peds.2016	peds.2016	PROPN
bptjm-38	240	2	-	-	PUNCT
bptjm-38	240	3	115f	115f	PROPN
bptjm-38	240	4	berkeley	berkeley	PROPN
bptjm-38	240	5	pharma	pharma	PROPN
bptjm-38	240	6	tech	tech	NOUN
bptjm-38	240	7	journal	journal	NOUN
bptjm-38	240	8	of	of	ADP
bptjm-38	240	9	medicine	medicine	NOUN
bptjm-38	240	10	|	|	ADV
bptjm-38	240	11	25	25	NUM