id	sid	tid	token	lemma	pos
bptjm-46	1	1	body	body	NOUN
bptjm-46	1	2	paragraph_fang	paragraph_fang	PROPN
bptjm-46	1	3	et	et	NOUN
bptjm-46	1	4	al._diabetes	al._diabete	NOUN
bptjm-46	1	5	-	-	PUNCT
bptjm-46	1	6	related	relate	VERB
bptjm-46	1	7	cancer.docx	cancer.docx	PROPN
bptjm-46	1	8	berkeley	berkeley	PROPN
bptjm-46	1	9	pharma	pharma	PROPN
bptjm-46	1	10	tech	tech	NOUN
bptjm-46	1	11	journal	journal	NOUN
bptjm-46	1	12	of	of	ADP
bptjm-46	1	13	medicine	medicine	NOUN
bptjm-46	1	14	correspondence	correspondence	NOUN
bptjm-46	1	15	:	:	PUNCT
bptjm-46	1	16	robertfang17@gmail.com	robertfang17@gmail.com	X
bptjm-46	1	17	keywords	keyword	NOUN
bptjm-46	1	18	:	:	PUNCT
bptjm-46	1	19	metabolic	metabolic	NOUN
bptjm-46	1	20	-	-	PUNCT
bptjm-46	1	21	reprogramming	reprogramme	VERB
bptjm-46	1	22	obesity	obesity	NOUN
bptjm-46	1	23	diabetes	diabetes	NOUN
bptjm-46	1	24	metformin	metformin	NOUN
bptjm-46	1	25	fasentin	fasentin	PROPN
bptjm-46	1	26	panitumumab	panitumumab	PROPN
bptjm-46	1	27	submitted	submit	VERB
bptjm-46	1	28	may	may	PROPN
bptjm-46	1	29	5	5	NUM
bptjm-46	1	30	,	,	PUNCT
bptjm-46	1	31	2023	2023	NUM
bptjm-46	1	32	accepted	accept	VERB
bptjm-46	1	33	july	july	PROPN
bptjm-46	1	34	7	7	NUM
bptjm-46	1	35	,	,	PUNCT
bptjm-46	1	36	2023	2023	NUM
bptjm-46	1	37	published	publish	VERB
bptjm-46	1	38	december	december	PROPN
bptjm-46	1	39	30	30	NUM
bptjm-46	1	40	,	,	PUNCT
bptjm-46	1	41	2023	2023	NUM
bptjm-46	1	42	full	full	ADJ
bptjm-46	1	43	open	open	ADJ
bptjm-46	1	44	access	access	NOUN
bptjm-46	1	45	creative	creative	ADJ
bptjm-46	1	46	commons	common	NOUN
bptjm-46	1	47	attribution	attribution	NOUN
bptjm-46	1	48	license	license	VERB
bptjm-46	1	49	4.0	4.0	NUM
bptjm-46	1	50	abstract	abstract	ADJ
bptjm-46	1	51	cancer	cancer	NOUN
bptjm-46	1	52	is	be	AUX
bptjm-46	1	53	a	a	DET
bptjm-46	1	54	condition	condition	NOUN
bptjm-46	1	55	characterized	characterize	VERB
bptjm-46	1	56	by	by	ADP
bptjm-46	1	57	the	the	DET
bptjm-46	1	58	uncontrolled	uncontrolled	ADJ
bptjm-46	1	59	growth	growth	NOUN
bptjm-46	1	60	and	and	CCONJ
bptjm-46	1	61	spreading	spread	VERB
bptjm-46	1	62	of	of	ADP
bptjm-46	1	63	certain	certain	ADJ
bptjm-46	1	64	cells	cell	NOUN
bptjm-46	1	65	within	within	ADP
bptjm-46	1	66	the	the	DET
bptjm-46	1	67	body	body	NOUN
bptjm-46	1	68	.	.	PUNCT
bptjm-46	2	1	the	the	DET
bptjm-46	2	2	formation	formation	NOUN
bptjm-46	2	3	of	of	ADP
bptjm-46	2	4	malignant	malignant	ADJ
bptjm-46	2	5	tumors	tumor	NOUN
bptjm-46	2	6	necessitates	necessitate	VERB
bptjm-46	2	7	a	a	DET
bptjm-46	2	8	substantial	substantial	ADJ
bptjm-46	2	9	amount	amount	NOUN
bptjm-46	2	10	of	of	ADP
bptjm-46	2	11	energy	energy	NOUN
bptjm-46	2	12	to	to	PART
bptjm-46	2	13	sustain	sustain	VERB
bptjm-46	2	14	the	the	DET
bptjm-46	2	15	abnormal	abnormal	ADJ
bptjm-46	2	16	rate	rate	NOUN
bptjm-46	2	17	of	of	ADP
bptjm-46	2	18	cell	cell	NOUN
bptjm-46	2	19	division	division	NOUN
bptjm-46	2	20	.	.	PUNCT
bptjm-46	3	1	this	this	DET
bptjm-46	3	2	process	process	NOUN
bptjm-46	3	3	leads	lead	VERB
bptjm-46	3	4	to	to	ADP
bptjm-46	3	5	a	a	DET
bptjm-46	3	6	significant	significant	ADJ
bptjm-46	3	7	alteration	alteration	NOUN
bptjm-46	3	8	in	in	ADP
bptjm-46	3	9	the	the	DET
bptjm-46	3	10	primary	primary	ADJ
bptjm-46	3	11	metabolic	metabolic	NOUN
bptjm-46	3	12	pathway	pathway	NOUN
bptjm-46	3	13	,	,	PUNCT
bptjm-46	3	14	transitioning	transition	VERB
bptjm-46	3	15	from	from	ADP
bptjm-46	3	16	mitochondrial	mitochondrial	ADJ
bptjm-46	3	17	respiration	respiration	NOUN
bptjm-46	3	18	to	to	ADP
bptjm-46	3	19	aerobic	aerobic	ADJ
bptjm-46	3	20	glycolysis	glycolysis	NOUN
bptjm-46	3	21	,	,	PUNCT
bptjm-46	3	22	particularly	particularly	ADV
bptjm-46	3	23	in	in	ADP
bptjm-46	3	24	cancers	cancer	NOUN
bptjm-46	3	25	associated	associate	VERB
bptjm-46	3	26	with	with	ADP
bptjm-46	3	27	diabetes	diabetes	NOUN
bptjm-46	3	28	.	.	PUNCT
bptjm-46	4	1	this	this	DET
bptjm-46	4	2	shift	shift	NOUN
bptjm-46	4	3	creates	create	VERB
bptjm-46	4	4	an	an	DET
bptjm-46	4	5	opportunity	opportunity	NOUN
bptjm-46	4	6	for	for	ADP
bptjm-46	4	7	less	less	ADV
bptjm-46	4	8	invasive	invasive	ADJ
bptjm-46	4	9	treatment	treatment	NOUN
bptjm-46	4	10	options	option	NOUN
bptjm-46	4	11	that	that	PRON
bptjm-46	4	12	can	can	AUX
bptjm-46	4	13	limit	limit	VERB
bptjm-46	4	14	cancer	cancer	NOUN
bptjm-46	4	15	growth	growth	NOUN
bptjm-46	4	16	by	by	ADP
bptjm-46	4	17	targeting	target	VERB
bptjm-46	4	18	specific	specific	ADJ
bptjm-46	4	19	transporters	transporter	NOUN
bptjm-46	4	20	and	and	CCONJ
bptjm-46	4	21	enzymes	enzyme	NOUN
bptjm-46	4	22	crucial	crucial	ADJ
bptjm-46	4	23	for	for	ADP
bptjm-46	4	24	energy	energy	NOUN
bptjm-46	4	25	production	production	NOUN
bptjm-46	4	26	.	.	PUNCT
bptjm-46	5	1	this	this	DET
bptjm-46	5	2	article	article	NOUN
bptjm-46	5	3	focuses	focus	VERB
bptjm-46	5	4	on	on	ADP
bptjm-46	5	5	the	the	DET
bptjm-46	5	6	biological	biological	ADJ
bptjm-46	5	7	functions	function	NOUN
bptjm-46	5	8	of	of	ADP
bptjm-46	5	9	fasentin	fasentin	NOUN
bptjm-46	5	10	and	and	CCONJ
bptjm-46	5	11	metformin	metformin	PROPN
bptjm-46	5	12	,	,	PUNCT
bptjm-46	5	13	exploring	explore	VERB
bptjm-46	5	14	their	their	PRON
bptjm-46	5	15	effectiveness	effectiveness	NOUN
bptjm-46	5	16	in	in	ADP
bptjm-46	5	17	constraining	constrain	VERB
bptjm-46	5	18	cancer	cancer	NOUN
bptjm-46	5	19	development	development	NOUN
bptjm-46	5	20	.	.	PUNCT
bptjm-46	6	1	the	the	DET
bptjm-46	6	2	discussion	discussion	NOUN
bptjm-46	6	3	delves	delve	VERB
bptjm-46	6	4	into	into	ADP
bptjm-46	6	5	their	their	PRON
bptjm-46	6	6	roles	role	NOUN
bptjm-46	6	7	in	in	ADP
bptjm-46	6	8	regulating	regulate	VERB
bptjm-46	6	9	metabolism	metabolism	NOUN
bptjm-46	6	10	and	and	CCONJ
bptjm-46	6	11	highlights	highlight	NOUN
bptjm-46	6	12	how	how	SCONJ
bptjm-46	6	13	these	these	DET
bptjm-46	6	14	drugs	drug	NOUN
bptjm-46	6	15	can	can	AUX
bptjm-46	6	16	be	be	AUX
bptjm-46	6	17	instrumental	instrumental	ADJ
bptjm-46	6	18	in	in	ADP
bptjm-46	6	19	impeding	impede	VERB
bptjm-46	6	20	the	the	DET
bptjm-46	6	21	progression	progression	NOUN
bptjm-46	6	22	of	of	ADP
bptjm-46	6	23	cancer	cancer	NOUN
bptjm-46	6	24	.	.	PUNCT
bptjm-46	7	1	effective	effective	ADJ
bptjm-46	7	2	reprogramming	reprogramme	VERB
bptjm-46	7	3	strategies	strategy	NOUN
bptjm-46	7	4	for	for	ADP
bptjm-46	7	5	treating	treat	VERB
bptjm-46	7	6	diabetes	diabetes	NOUN
bptjm-46	7	7	-	-	PUNCT
bptjm-46	7	8	related	relate	VERB
bptjm-46	7	9	cancer	cancer	NOUN
bptjm-46	7	10	:	:	PUNCT
bptjm-46	7	11	a	a	DET
bptjm-46	7	12	focus	focus	NOUN
bptjm-46	7	13	on	on	ADP
bptjm-46	7	14	fasentin	fasentin	PROPN
bptjm-46	7	15	,	,	PUNCT
bptjm-46	7	16	metformin	metformin	NOUN
bptjm-46	7	17	,	,	PUNCT
bptjm-46	7	18	and	and	CCONJ
bptjm-46	7	19	panitumumab	panitumumab	NOUN
bptjm-46	7	20	therapies	therapy	NOUN
bptjm-46	7	21	by	by	ADP
bptjm-46	7	22	:	:	PUNCT
bptjm-46	7	23	heyi	heyi	PROPN
bptjm-46	7	24	fang	fang	PROPN
bptjm-46	7	25	,	,	PUNCT
bptjm-46	7	26	hailey	hailey	NOUN
bptjm-46	7	27	guinto	guinto	NOUN
bptjm-46	7	28	,	,	PUNCT
bptjm-46	7	29	and	and	CCONJ
bptjm-46	7	30	harshita	harshita	PROPN
bptjm-46	7	31	pinneboina	pinneboina	PROPN
bptjm-46	7	32	1	1	X
bptjm-46	7	33	.	.	PUNCT
bptjm-46	7	34	introduction	introduction	NOUN
bptjm-46	7	35	since	since	SCONJ
bptjm-46	7	36	its	its	PRON
bptjm-46	7	37	initial	initial	ADJ
bptjm-46	7	38	discovery	discovery	NOUN
bptjm-46	8	1	,	,	PUNCT
bptjm-46	8	2	cancer	cancer	NOUN
bptjm-46	8	3	has	have	AUX
bptjm-46	8	4	been	be	AUX
bptjm-46	8	5	one	one	NUM
bptjm-46	8	6	of	of	ADP
bptjm-46	8	7	the	the	DET
bptjm-46	8	8	most	most	ADV
bptjm-46	8	9	formidable	formidable	ADJ
bptjm-46	8	10	diseases	disease	NOUN
bptjm-46	8	11	.	.	PUNCT
bptjm-46	9	1	though	though	SCONJ
bptjm-46	9	2	its	its	PRON
bptjm-46	9	3	early	early	ADJ
bptjm-46	9	4	-	-	PUNCT
bptjm-46	9	5	stage	stage	NOUN
bptjm-46	9	6	symptoms	symptom	NOUN
bptjm-46	9	7	are	be	AUX
bptjm-46	9	8	less	less	ADV
bptjm-46	9	9	virulent	virulent	ADJ
bptjm-46	9	10	and	and	CCONJ
bptjm-46	9	11	the	the	DET
bptjm-46	9	12	rate	rate	NOUN
bptjm-46	9	13	of	of	ADP
bptjm-46	9	14	recovery	recovery	NOUN
bptjm-46	9	15	can	can	AUX
bptjm-46	9	16	be	be	AUX
bptjm-46	9	17	as	as	ADV
bptjm-46	9	18	high	high	ADJ
bptjm-46	9	19	as	as	ADP
bptjm-46	9	20	90	90	NUM
bptjm-46	9	21	%	%	NOUN
bptjm-46	9	22	,	,	PUNCT
bptjm-46	9	23	advanced	advanced	ADJ
bptjm-46	9	24	stages	stage	NOUN
bptjm-46	9	25	are	be	AUX
bptjm-46	9	26	faced	face	VERB
bptjm-46	9	27	with	with	ADP
bptjm-46	9	28	a	a	DET
bptjm-46	9	29	high	high	ADJ
bptjm-46	9	30	mortality	mortality	NOUN
bptjm-46	9	31	rate	rate	NOUN
bptjm-46	9	32	.	.	PUNCT
bptjm-46	10	1	during	during	ADP
bptjm-46	10	2	intermediate	intermediate	ADJ
bptjm-46	10	3	and	and	CCONJ
bptjm-46	10	4	advanced	advanced	ADJ
bptjm-46	10	5	stages	stage	NOUN
bptjm-46	10	6	,	,	PUNCT
bptjm-46	10	7	common	common	ADJ
bptjm-46	10	8	treatments	treatment	NOUN
bptjm-46	10	9	are	be	AUX
bptjm-46	10	10	invasive	invasive	ADJ
bptjm-46	10	11	and	and	CCONJ
bptjm-46	10	12	seek	seek	VERB
bptjm-46	10	13	to	to	PART
bptjm-46	10	14	eradicate	eradicate	VERB
bptjm-46	10	15	all	all	DET
bptjm-46	10	16	cancer	cancer	NOUN
bptjm-46	10	17	cells	cell	NOUN
bptjm-46	10	18	-though	-though	ADJ
bptjm-46	10	19	recurrence	recurrence	NOUN
bptjm-46	10	20	is	be	AUX
bptjm-46	10	21	possible	possible	ADJ
bptjm-46	10	22	.	.	PUNCT
bptjm-46	11	1	if	if	SCONJ
bptjm-46	11	2	the	the	DET
bptjm-46	11	3	cancer	cancer	NOUN
bptjm-46	11	4	progresses	progress	VERB
bptjm-46	11	5	to	to	ADP
bptjm-46	11	6	advanced	advanced	ADJ
bptjm-46	11	7	stages	stage	NOUN
bptjm-46	11	8	,	,	PUNCT
bptjm-46	11	9	however	however	ADV
bptjm-46	11	10	,	,	PUNCT
bptjm-46	11	11	the	the	DET
bptjm-46	11	12	mortality	mortality	NOUN
bptjm-46	11	13	rate	rate	NOUN
bptjm-46	11	14	will	will	AUX
bptjm-46	11	15	quickly	quickly	ADV
bptjm-46	11	16	rise	rise	VERB
bptjm-46	11	17	to	to	ADP
bptjm-46	11	18	70	70	NUM
bptjm-46	11	19	%	%	NOUN
bptjm-46	11	20	over	over	ADP
bptjm-46	11	21	the	the	DET
bptjm-46	11	22	span	span	NOUN
bptjm-46	11	23	of	of	ADP
bptjm-46	11	24	�	�	PROPN
bptjm-46	11	25	ve	ve	NOUN
bptjm-46	11	26	years.1	years.1	NOUN
bptjm-46	11	27	there	there	PRON
bptjm-46	11	28	are	be	VERB
bptjm-46	11	29	various	various	ADJ
bptjm-46	11	30	causes	cause	NOUN
bptjm-46	11	31	and	and	CCONJ
bptjm-46	11	32	risk	risk	NOUN
bptjm-46	11	33	factors	factor	NOUN
bptjm-46	11	34	for	for	ADP
bptjm-46	11	35	di	di	NOUN
bptjm-46	11	36	�	�	PROPN
bptjm-46	11	37	erent	erent	NOUN
bptjm-46	11	38	types	type	NOUN
bptjm-46	11	39	of	of	ADP
bptjm-46	11	40	cancer	cancer	NOUN
bptjm-46	11	41	,	,	PUNCT
bptjm-46	11	42	but	but	CCONJ
bptjm-46	11	43	chronic	chronic	ADJ
bptjm-46	11	44	diseases2	diseases2	NOUN
bptjm-46	11	45	,	,	PUNCT
bptjm-46	11	46	high	high	ADJ
bptjm-46	11	47	body	body	NOUN
bptjm-46	11	48	mass	mass	NOUN
bptjm-46	11	49	index	index	NOUN
bptjm-46	11	50	,	,	PUNCT
bptjm-46	11	51	(	(	PUNCT
bptjm-46	11	52	bmi	bmi	PROPN
bptjm-46	11	53	)	)	PUNCT
bptjm-46	11	54	and	and	CCONJ
bptjm-46	11	55	unhealthy	unhealthy	ADJ
bptjm-46	11	56	lifestyles	lifestyle	NOUN
bptjm-46	11	57	appear	appear	VERB
bptjm-46	11	58	as	as	ADP
bptjm-46	11	59	general	general	ADJ
bptjm-46	11	60	components	component	NOUN
bptjm-46	11	61	in	in	ADP
bptjm-46	11	62	all	all	DET
bptjm-46	11	63	types	type	NOUN
bptjm-46	11	64	.	.	PUNCT
bptjm-46	12	1	diabetes	diabetes	NOUN
bptjm-46	12	2	mellitus	mellitus	NOUN
bptjm-46	12	3	,	,	PUNCT
bptjm-46	12	4	one	one	NUM
bptjm-46	12	5	of	of	ADP
bptjm-46	12	6	the	the	DET
bptjm-46	12	7	most	most	ADV
bptjm-46	12	8	common	common	ADJ
bptjm-46	12	9	chronic	chronic	ADJ
bptjm-46	12	10	diseases	disease	NOUN
bptjm-46	12	11	,	,	PUNCT
bptjm-46	12	12	has	have	AUX
bptjm-46	12	13	proved	prove	VERB
bptjm-46	12	14	to	to	PART
bptjm-46	12	15	be	be	AUX
bptjm-46	12	16	positively	positively	ADV
bptjm-46	12	17	correlated	correlate	VERB
bptjm-46	12	18	with	with	ADP
bptjm-46	12	19	the	the	DET
bptjm-46	12	20	progression	progression	NOUN
bptjm-46	12	21	of	of	ADP
bptjm-46	12	22	cancer	cancer	NOUN
bptjm-46	12	23	.	.	PUNCT
bptjm-46	13	1	diabetes	diabetes	NOUN
bptjm-46	13	2	mellitus	mellitus	NOUN
bptjm-46	13	3	refers	refer	VERB
bptjm-46	13	4	to	to	ADP
bptjm-46	13	5	a	a	DET
bptjm-46	13	6	group	group	NOUN
bptjm-46	13	7	of	of	ADP
bptjm-46	13	8	diseases	disease	NOUN
bptjm-46	13	9	that	that	PRON
bptjm-46	13	10	a	a	DET
bptjm-46	13	11	�	�	NOUN
bptjm-46	13	12	ect	ect	VERB
bptjm-46	13	13	how	how	SCONJ
bptjm-46	13	14	the	the	DET
bptjm-46	13	15	body	body	NOUN
bptjm-46	13	16	uses	use	VERB
bptjm-46	13	17	blood	blood	NOUN
bptjm-46	13	18	glucose	glucose	NOUN
bptjm-46	13	19	with	with	ADP
bptjm-46	13	20	regulations	regulation	NOUN
bptjm-46	13	21	by	by	ADP
bptjm-46	13	22	insulin	insulin	NOUN
bptjm-46	13	23	,	,	PUNCT
bptjm-46	13	24	adiponectin	adiponectin	NOUN
bptjm-46	13	25	,	,	PUNCT
bptjm-46	13	26	leptin	leptin	NOUN
bptjm-46	13	27	,	,	PUNCT
bptjm-46	13	28	and	and	CCONJ
bptjm-46	13	29	glucose	glucose	NOUN
bptjm-46	13	30	transporter	transporter	NOUN
bptjm-46	13	31	groups	group	NOUN
bptjm-46	13	32	(	(	PUNCT
bptjm-46	13	33	gluts	gluts	PROPN
bptjm-46	13	34	)	)	PUNCT
bptjm-46	13	35	that	that	PRON
bptjm-46	13	36	manipulates	manipulate	VERB
bptjm-46	13	37	the	the	DET
bptjm-46	13	38	metabolic	metabolic	PROPN
bptjm-46	13	39	�	�	PROPN
bptjm-46	13	40	ux	ux	PROPN
bptjm-46	13	41	of	of	ADP
bptjm-46	13	42	metabolites	metabolite	NOUN
bptjm-46	13	43	between	between	ADP
bptjm-46	13	44	bloodstream	bloodstream	NOUN
bptjm-46	13	45	and	and	CCONJ
bptjm-46	13	46	peripheral	peripheral	ADJ
bptjm-46	13	47	tissues	tissue	NOUN
bptjm-46	13	48	with	with	ADP
bptjm-46	13	49	energy	energy	NOUN
bptjm-46	13	50	needs	need	NOUN
bptjm-46	13	51	.	.	PUNCT
bptjm-46	14	1	type	type	NOUN
bptjm-46	14	2	i	i	PRON
bptjm-46	14	3	diabetes	diabetes	NOUN
bptjm-46	14	4	will	will	AUX
bptjm-46	14	5	disable	disable	VERB
bptjm-46	14	6	the	the	DET
bptjm-46	14	7	pancreas	pancreas	NOUN
bptjm-46	14	8	from	from	ADP
bptjm-46	14	9	producing	produce	VERB
bptjm-46	14	10	insulin	insulin	NOUN
bptjm-46	14	11	and	and	CCONJ
bptjm-46	14	12	type	type	NOUN
bptjm-46	14	13	ii	ii	PROPN
bptjm-46	14	14	diabetes	diabetes	NOUN
bptjm-46	14	15	is	be	AUX
bptjm-46	14	16	characterized	characterize	VERB
bptjm-46	14	17	by	by	ADP
bptjm-46	14	18	insulin	insulin	NOUN
bptjm-46	14	19	resistance	resistance	NOUN
bptjm-46	14	20	,	,	PUNCT
bptjm-46	14	21	which	which	PRON
bptjm-46	14	22	heavily	heavily	ADV
bptjm-46	14	23	impairs	impair	VERB
bptjm-46	14	24	the	the	DET
bptjm-46	14	25	patient	patient	NOUN
bptjm-46	14	26	's	's	PART
bptjm-46	14	27	ability	ability	NOUN
bptjm-46	14	28	to	to	PART
bptjm-46	14	29	utilize	utilize	VERB
bptjm-46	14	30	insulin	insulin	NOUN
bptjm-46	14	31	for	for	ADP
bptjm-46	14	32	the	the	DET
bptjm-46	14	33	regulation	regulation	NOUN
bptjm-46	14	34	of	of	ADP
bptjm-46	14	35	sugar	sugar	NOUN
bptjm-46	14	36	.	.	PUNCT
bptjm-46	15	1	insulin	insulin	NOUN
bptjm-46	15	2	is	be	AUX
bptjm-46	15	3	a	a	DET
bptjm-46	15	4	hormone	hormone	NOUN
bptjm-46	15	5	secreted	secrete	VERB
bptjm-46	15	6	by	by	ADP
bptjm-46	15	7	the	the	DET
bptjm-46	15	8	pancreas	pancrea	NOUN
bptjm-46	15	9	and	and	CCONJ
bptjm-46	15	10	is	be	AUX
bptjm-46	15	11	used	use	VERB
bptjm-46	15	12	extensively	extensively	ADV
bptjm-46	15	13	for	for	ADP
bptjm-46	15	14	the	the	DET
bptjm-46	15	15	metabolism	metabolism	NOUN
bptjm-46	15	16	of	of	ADP
bptjm-46	15	17	glucose	glucose	NOUN
bptjm-46	15	18	and	and	CCONJ
bptjm-46	15	19	adipose	adipose	PRON
bptjm-46	15	20	tissue	tissue	NOUN
bptjm-46	15	21	after	after	ADP
bptjm-46	15	22	food	food	NOUN
bptjm-46	15	23	intake	intake	NOUN
bptjm-46	15	24	,	,	PUNCT
bptjm-46	15	25	especially	especially	ADV
bptjm-46	15	26	for	for	ADP
bptjm-46	15	27	the	the	DET
bptjm-46	15	28	synthesis	synthesis	NOUN
bptjm-46	15	29	of	of	ADP
bptjm-46	15	30	glycogen	glycogen	NOUN
bptjm-46	15	31	.	.	PUNCT
bptjm-46	16	1	glucose	glucose	NOUN
bptjm-46	16	2	is	be	AUX
bptjm-46	16	3	the	the	DET
bptjm-46	16	4	major	major	ADJ
bptjm-46	16	5	energy	energy	NOUN
bptjm-46	16	6	source	source	NOUN
bptjm-46	16	7	and	and	CCONJ
bptjm-46	16	8	upon	upon	SCONJ
bptjm-46	16	9	the	the	DET
bptjm-46	16	10	damage	damage	NOUN
bptjm-46	16	11	of	of	ADP
bptjm-46	16	12	insulin	insulin	NOUN
bptjm-46	16	13	's	's	PART
bptjm-46	16	14	function	function	NOUN
bptjm-46	16	15	,	,	PUNCT
bptjm-46	16	16	the	the	DET
bptjm-46	16	17	homeostasis	homeostasis	NOUN
bptjm-46	16	18	for	for	ADP
bptjm-46	16	19	glucose	glucose	NOUN
bptjm-46	16	20	and	and	CCONJ
bptjm-46	16	21	glycogen	glycogen	NOUN
bptjm-46	16	22	is	be	AUX
bptjm-46	16	23	broken	break	VERB
bptjm-46	16	24	.	.	PUNCT
bptjm-46	17	1	insulin	insulin	NOUN
bptjm-46	17	2	also	also	ADV
bptjm-46	17	3	serves	serve	VERB
bptjm-46	17	4	as	as	ADP
bptjm-46	17	5	a	a	DET
bptjm-46	17	6	negative	negative	ADJ
bptjm-46	17	7	feedback	feedback	NOUN
bptjm-46	17	8	signal	signal	NOUN
bptjm-46	17	9	for	for	ADP
bptjm-46	17	10	glycogenolysis	glycogenolysis	NOUN
bptjm-46	17	11	,	,	PUNCT
bptjm-46	17	12	which	which	PRON
bptjm-46	17	13	transforms	transform	VERB
bptjm-46	17	14	stored	store	VERB
bptjm-46	17	15	glycogen	glycogen	NOUN
bptjm-46	17	16	to	to	ADP
bptjm-46	17	17	free	free	ADJ
bptjm-46	17	18	glucose	glucose	NOUN
bptjm-46	17	19	.	.	PUNCT
bptjm-46	18	1	moreover	moreover	ADV
bptjm-46	18	2	,	,	PUNCT
bptjm-46	18	3	more	more	ADJ
bptjm-46	18	4	insulin	insulin	NOUN
bptjm-46	18	5	circulating	circulate	VERB
bptjm-46	18	6	in	in	ADP
bptjm-46	18	7	the	the	DET
bptjm-46	18	8	bloodstream	bloodstream	NOUN
bptjm-46	18	9	will	will	AUX
bptjm-46	18	10	inhibit	inhibit	VERB
bptjm-46	18	11	the	the	DET
bptjm-46	18	12	synthesis	synthesis	NOUN
bptjm-46	18	13	of	of	ADP
bptjm-46	18	14	various	various	ADJ
bptjm-46	18	15	proteins	protein	NOUN
bptjm-46	18	16	in	in	ADP
bptjm-46	18	17	di	di	NOUN
bptjm-46	18	18	�	�	PROPN
bptjm-46	18	19	erent	erent	NOUN
bptjm-46	18	20	tissues	tissue	NOUN
bptjm-46	18	21	,	,	PUNCT
bptjm-46	18	22	interfering	interfere	VERB
bptjm-46	18	23	with	with	ADP
bptjm-46	18	24	normal	normal	ADJ
bptjm-46	18	25	physiological	physiological	ADJ
bptjm-46	18	26	functions	function	NOUN
bptjm-46	18	27	throughout	throughout	ADP
bptjm-46	18	28	the	the	DET
bptjm-46	18	29	body	body	NOUN
bptjm-46	18	30	,	,	PUNCT
bptjm-46	18	31	especially	especially	ADV
bptjm-46	18	32	in	in	ADP
bptjm-46	18	33	the	the	DET
bptjm-46	18	34	digestive	digestive	ADJ
bptjm-46	18	35	system	system	NOUN
bptjm-46	18	36	.	.	PUNCT
bptjm-46	19	1	in	in	ADP
bptjm-46	19	2	discussion	discussion	NOUN
bptjm-46	19	3	of	of	ADP
bptjm-46	19	4	diabetes	diabetes	NOUN
bptjm-46	19	5	and	and	CCONJ
bptjm-46	19	6	the	the	DET
bptjm-46	19	7	risk	risk	NOUN
bptjm-46	19	8	of	of	ADP
bptjm-46	19	9	faster	fast	ADJ
bptjm-46	19	10	cancer	cancer	NOUN
bptjm-46	19	11	progression	progression	NOUN
bptjm-46	19	12	,	,	PUNCT
bptjm-46	19	13	diabetes	diabete	NOUN
bptjm-46	19	14	provides	provide	VERB
bptjm-46	19	15	extra	extra	ADJ
bptjm-46	19	16	energy	energy	NOUN
bptjm-46	19	17	supply	supply	NOUN
bptjm-46	19	18	to	to	ADP
bptjm-46	19	19	the	the	DET
bptjm-46	19	20	uncontrolled	uncontrolled	ADJ
bptjm-46	19	21	dividing	divide	VERB
bptjm-46	19	22	cancer	cancer	NOUN
bptjm-46	19	23	cells	cell	NOUN
bptjm-46	19	24	,	,	PUNCT
bptjm-46	19	25	�	�	NOUN
bptjm-46	19	26	lling	lle	VERB
bptjm-46	19	27	the	the	DET
bptjm-46	19	28	gap	gap	NOUN
bptjm-46	19	29	with	with	ADP
bptjm-46	19	30	an	an	DET
bptjm-46	19	31	abnormally	abnormally	ADV
bptjm-46	19	32	high	high	ADJ
bptjm-46	19	33	consumption	consumption	NOUN
bptjm-46	19	34	of	of	ADP
bptjm-46	19	35	energy	energy	NOUN
bptjm-46	19	36	.	.	PUNCT
bptjm-46	20	1	heavily	heavily	ADV
bptjm-46	20	2	depending	depend	VERB
bptjm-46	20	3	on	on	ADP
bptjm-46	20	4	the	the	DET
bptjm-46	20	5	intake	intake	NOUN
bptjm-46	20	6	of	of	ADP
bptjm-46	20	7	energy	energy	NOUN
bptjm-46	20	8	,	,	PUNCT
bptjm-46	20	9	the	the	DET
bptjm-46	20	10	shifted	shift	VERB
bptjm-46	20	11	metabolic	metabolic	NOUN
bptjm-46	20	12	mechanism	mechanism	NOUN
bptjm-46	20	13	is	be	AUX
bptjm-46	20	14	a	a	DET
bptjm-46	20	15	novel	novel	ADJ
bptjm-46	20	16	interest	interest	NOUN
bptjm-46	20	17	for	for	ADP
bptjm-46	20	18	the	the	DET
bptjm-46	20	19	treatment	treatment	NOUN
bptjm-46	20	20	of	of	ADP
bptjm-46	20	21	diabetes	diabetes	NOUN
bptjm-46	20	22	-	-	PUNCT
bptjm-46	20	23	related	relate	VERB
bptjm-46	20	24	cancer	cancer	NOUN
bptjm-46	20	25	.	.	PUNCT
bptjm-46	21	1	the	the	DET
bptjm-46	21	2	complex	complex	ADJ
bptjm-46	21	3	energy	energy	NOUN
bptjm-46	21	4	transfer	transfer	NOUN
bptjm-46	21	5	process	process	NOUN
bptjm-46	21	6	including	include	VERB
bptjm-46	21	7	the	the	DET
bptjm-46	21	8	berkeley	berkeley	PROPN
bptjm-46	21	9	pharma	pharma	PROPN
bptjm-46	21	10	tech	tech	NOUN
bptjm-46	21	11	journal	journal	NOUN
bptjm-46	21	12	of	of	ADP
bptjm-46	21	13	medicine	medicine	NOUN
bptjm-46	21	14	|	|	ADV
bptjm-46	21	15	102	102	NUM
bptjm-46	21	16	use	use	NOUN
bptjm-46	21	17	of	of	ADP
bptjm-46	21	18	insulin	insulin	NOUN
bptjm-46	21	19	,	,	PUNCT
bptjm-46	21	20	glucose	glucose	NOUN
bptjm-46	21	21	transporter	transporter	NOUN
bptjm-46	21	22	,	,	PUNCT
bptjm-46	21	23	and	and	CCONJ
bptjm-46	21	24	the	the	DET
bptjm-46	21	25	change	change	NOUN
bptjm-46	21	26	-	-	PUNCT
bptjm-46	21	27	of	of	ADP
bptjm-46	21	28	-	-	PUNCT
bptjm-46	21	29	function	function	NOUN
bptjm-46	21	30	of	of	ADP
bptjm-46	21	31	many	many	ADJ
bptjm-46	21	32	metabolism	metabolism	NOUN
bptjm-46	21	33	-	-	PUNCT
bptjm-46	21	34	related	relate	VERB
bptjm-46	21	35	cells	cell	NOUN
bptjm-46	21	36	in	in	ADP
bptjm-46	21	37	mitochondria	mitochondria	NOUN
bptjm-46	21	38	are	be	AUX
bptjm-46	21	39	hypothesized	hypothesize	VERB
bptjm-46	21	40	as	as	ADP
bptjm-46	21	41	new	new	ADJ
bptjm-46	21	42	aims	aim	NOUN
bptjm-46	21	43	with	with	ADP
bptjm-46	21	44	a	a	DET
bptjm-46	21	45	non	non	ADJ
bptjm-46	21	46	-	-	ADJ
bptjm-46	21	47	invasive	invasive	ADJ
bptjm-46	21	48	treatment	treatment	NOUN
bptjm-46	21	49	:	:	PUNCT
bptjm-46	21	50	treatment	treatment	NOUN
bptjm-46	21	51	with	with	ADP
bptjm-46	21	52	no	no	DET
bptjm-46	21	53	need	need	NOUN
bptjm-46	21	54	of	of	ADP
bptjm-46	21	55	physical	physical	ADJ
bptjm-46	21	56	insertion	insertion	NOUN
bptjm-46	21	57	of	of	ADP
bptjm-46	21	58	instruments	instrument	NOUN
bptjm-46	21	59	into	into	ADP
bptjm-46	21	60	the	the	DET
bptjm-46	21	61	patient	patient	NOUN
bptjm-46	21	62	’s	’s	PART
bptjm-46	21	63	body	body	NOUN
bptjm-46	21	64	.	.	PUNCT
bptjm-46	22	1	in	in	ADP
bptjm-46	22	2	this	this	DET
bptjm-46	22	3	article	article	NOUN
bptjm-46	22	4	,	,	PUNCT
bptjm-46	22	5	the	the	DET
bptjm-46	22	6	relationship	relationship	NOUN
bptjm-46	22	7	among	among	ADP
bptjm-46	22	8	the	the	DET
bptjm-46	22	9	chain	chain	NOUN
bptjm-46	22	10	of	of	ADP
bptjm-46	22	11	obesity	obesity	NOUN
bptjm-46	22	12	,	,	PUNCT
bptjm-46	22	13	diabetes	diabetes	NOUN
bptjm-46	22	14	mellitus	mellitus	NOUN
bptjm-46	22	15	,	,	PUNCT
bptjm-46	22	16	and	and	CCONJ
bptjm-46	22	17	cancer	cancer	NOUN
bptjm-46	22	18	development	development	NOUN
bptjm-46	22	19	researched	research	VERB
bptjm-46	22	20	by	by	ADP
bptjm-46	22	21	di	di	NOUN
bptjm-46	22	22	�	�	PROPN
bptjm-46	22	23	erent	erent	NOUN
bptjm-46	22	24	articles	article	NOUN
bptjm-46	22	25	regarding	regard	VERB
bptjm-46	22	26	to	to	ADP
bptjm-46	22	27	distinct	distinct	ADJ
bptjm-46	22	28	diabetes	diabetes	NOUN
bptjm-46	22	29	-	-	PUNCT
bptjm-46	22	30	associated	associate	VERB
bptjm-46	22	31	cancer	cancer	NOUN
bptjm-46	22	32	types	type	NOUN
bptjm-46	22	33	is	be	AUX
bptjm-46	22	34	reviewed	review	VERB
bptjm-46	22	35	,	,	PUNCT
bptjm-46	22	36	the	the	DET
bptjm-46	22	37	potential	potential	ADJ
bptjm-46	22	38	metabolic	metabolic	NOUN
bptjm-46	22	39	reprogramming	reprogramme	VERB
bptjm-46	22	40	pathways	pathway	NOUN
bptjm-46	22	41	of	of	ADP
bptjm-46	22	42	glucose	glucose	NOUN
bptjm-46	22	43	uptake	uptake	NOUN
bptjm-46	22	44	and	and	CCONJ
bptjm-46	22	45	digestion	digestion	NOUN
bptjm-46	22	46	by	by	ADP
bptjm-46	22	47	cancer	cancer	NOUN
bptjm-46	22	48	cells	cell	NOUN
bptjm-46	22	49	are	be	AUX
bptjm-46	22	50	studied	study	VERB
bptjm-46	22	51	,	,	PUNCT
bptjm-46	22	52	and	and	CCONJ
bptjm-46	22	53	the	the	DET
bptjm-46	22	54	mechanisms	mechanism	NOUN
bptjm-46	22	55	of	of	ADP
bptjm-46	22	56	inhibitory	inhibitory	ADJ
bptjm-46	22	57	functions	function	NOUN
bptjm-46	22	58	on	on	ADP
bptjm-46	22	59	process	process	NOUN
bptjm-46	22	60	of	of	ADP
bptjm-46	22	61	reprogramming	reprogramme	VERB
bptjm-46	22	62	by	by	ADP
bptjm-46	22	63	fasentin	fasentin	NOUN
bptjm-46	22	64	,	,	PUNCT
bptjm-46	22	65	panitumumab	panitumumab	NOUN
bptjm-46	22	66	,	,	PUNCT
bptjm-46	22	67	and	and	CCONJ
bptjm-46	22	68	metformin	metformin	NOUN
bptjm-46	22	69	are	be	AUX
bptjm-46	22	70	possessed	possess	VERB
bptjm-46	22	71	for	for	ADP
bptjm-46	22	72	the	the	DET
bptjm-46	22	73	possibility	possibility	NOUN
bptjm-46	22	74	as	as	ADP
bptjm-46	22	75	drug	drug	NOUN
bptjm-46	22	76	treatments	treatment	NOUN
bptjm-46	22	77	of	of	ADP
bptjm-46	22	78	diabetes	diabetes	NOUN
bptjm-46	22	79	-	-	PUNCT
bptjm-46	22	80	associated	associate	VERB
bptjm-46	22	81	cancer	cancer	NOUN
bptjm-46	22	82	.	.	PUNCT
bptjm-46	23	1	2	2	X
bptjm-46	23	2	.	.	X
bptjm-46	23	3	obesity	obesity	NOUN
bptjm-46	23	4	and	and	CCONJ
bptjm-46	23	5	its	its	PRON
bptjm-46	23	6	correlation	correlation	NOUN
bptjm-46	23	7	to	to	PART
bptjm-46	23	8	diabetes	diabetes	NOUN
bptjm-46	23	9	development	development	NOUN
bptjm-46	23	10	obesity	obesity	NOUN
bptjm-46	23	11	is	be	AUX
bptjm-46	23	12	considered	consider	VERB
bptjm-46	23	13	a	a	DET
bptjm-46	23	14	common	common	ADJ
bptjm-46	23	15	risk	risk	NOUN
bptjm-46	23	16	factor	factor	NOUN
bptjm-46	23	17	for	for	ADP
bptjm-46	23	18	many	many	ADJ
bptjm-46	23	19	diseases3	diseases3	PROPN
bptjm-46	23	20	.	.	PUNCT
bptjm-46	24	1	regarding	regard	VERB
bptjm-46	24	2	the	the	DET
bptjm-46	24	3	accumulation	accumulation	NOUN
bptjm-46	24	4	of	of	ADP
bptjm-46	24	5	excess	excess	ADJ
bptjm-46	24	6	adipose	adipose	ADJ
bptjm-46	24	7	tissue	tissue	NOUN
bptjm-46	24	8	,	,	PUNCT
bptjm-46	24	9	a	a	DET
bptjm-46	24	10	body	body	NOUN
bptjm-46	24	11	mass	mass	NOUN
bptjm-46	24	12	index	index	NOUN
bptjm-46	24	13	(	(	PUNCT
bptjm-46	24	14	bmi	bmi	PROPN
bptjm-46	24	15	)	)	PUNCT
bptjm-46	24	16	of	of	ADP
bptjm-46	24	17	over	over	ADP
bptjm-46	24	18	30	30	NUM
bptjm-46	24	19	kg	kg	NOUN
bptjm-46	24	20	/	/	SYM
bptjm-46	24	21	m2	m2	PROPN
bptjm-46	24	22	is	be	AUX
bptjm-46	24	23	utilized	utilize	VERB
bptjm-46	24	24	as	as	ADP
bptjm-46	24	25	an	an	DET
bptjm-46	24	26	indicator	indicator	NOUN
bptjm-46	24	27	.	.	PUNCT
bptjm-46	25	1	obesity	obesity	NOUN
bptjm-46	25	2	leads	lead	VERB
bptjm-46	25	3	to	to	ADP
bptjm-46	25	4	metabolic	metabolic	NOUN
bptjm-46	25	5	disturbance	disturbance	NOUN
bptjm-46	25	6	,	,	PUNCT
bptjm-46	25	7	the	the	DET
bptjm-46	25	8	severe	severe	ADJ
bptjm-46	25	9	impairments	impairment	NOUN
bptjm-46	25	10	of	of	ADP
bptjm-46	25	11	the	the	DET
bptjm-46	25	12	ability	ability	NOUN
bptjm-46	25	13	to	to	PART
bptjm-46	25	14	regulate	regulate	VERB
bptjm-46	25	15	the	the	DET
bptjm-46	25	16	synthesis	synthesis	NOUN
bptjm-46	25	17	of	of	ADP
bptjm-46	25	18	adipocytokines	adipocytokine	NOUN
bptjm-46	25	19	and	and	CCONJ
bptjm-46	25	20	the	the	DET
bptjm-46	25	21	conversion	conversion	NOUN
bptjm-46	25	22	between	between	ADP
bptjm-46	25	23	glucose	glucose	NOUN
bptjm-46	25	24	and	and	CCONJ
bptjm-46	25	25	glycogen	glycogen	NOUN
bptjm-46	25	26	.	.	PUNCT
bptjm-46	26	1	researchers	researcher	NOUN
bptjm-46	26	2	have	have	AUX
bptjm-46	26	3	revealed	reveal	VERB
bptjm-46	26	4	that	that	SCONJ
bptjm-46	26	5	common	common	ADJ
bptjm-46	26	6	metabolic	metabolic	NOUN
bptjm-46	26	7	disturbances	disturbance	NOUN
bptjm-46	26	8	like	like	ADP
bptjm-46	26	9	dyslipidemia	dyslipidemia	NOUN
bptjm-46	26	10	and	and	CCONJ
bptjm-46	26	11	hyperinsulinemia	hyperinsulinemia	NOUN
bptjm-46	26	12	are	be	AUX
bptjm-46	26	13	the	the	DET
bptjm-46	26	14	causal	causal	ADJ
bptjm-46	26	15	factors	factor	NOUN
bptjm-46	26	16	of	of	ADP
bptjm-46	26	17	cancer	cancer	NOUN
bptjm-46	26	18	development	development	NOUN
bptjm-46	26	19	.	.	PUNCT
bptjm-46	27	1	many	many	ADJ
bptjm-46	27	2	adipose	adipose	ADJ
bptjm-46	27	3	cytokines	cytokine	NOUN
bptjm-46	27	4	are	be	AUX
bptjm-46	27	5	critical	critical	ADJ
bptjm-46	27	6	regulators	regulator	NOUN
bptjm-46	27	7	for	for	ADP
bptjm-46	27	8	the	the	DET
bptjm-46	27	9	maintenance	maintenance	NOUN
bptjm-46	27	10	of	of	ADP
bptjm-46	27	11	homeostasis	homeostasis	NOUN
bptjm-46	27	12	between	between	ADP
bptjm-46	27	13	glucose	glucose	NOUN
bptjm-46	27	14	and	and	CCONJ
bptjm-46	27	15	energy	energy	NOUN
bptjm-46	27	16	supply	supply	NOUN
bptjm-46	27	17	with	with	ADP
bptjm-46	27	18	some	some	PRON
bptjm-46	27	19	of	of	ADP
bptjm-46	27	20	them	they	PRON
bptjm-46	27	21	impacting	impact	VERB
bptjm-46	27	22	a	a	DET
bptjm-46	27	23	range	range	NOUN
bptjm-46	27	24	of	of	ADP
bptjm-46	27	25	metabolic	metabolic	NOUN
bptjm-46	27	26	pathways	pathway	NOUN
bptjm-46	27	27	to	to	ADP
bptjm-46	27	28	other	other	ADJ
bptjm-46	27	29	organs	organ	NOUN
bptjm-46	27	30	.	.	PUNCT
bptjm-46	28	1	two	two	NUM
bptjm-46	28	2	of	of	ADP
bptjm-46	28	3	the	the	DET
bptjm-46	28	4	most	most	ADV
bptjm-46	28	5	intensively	intensively	ADV
bptjm-46	28	6	studied	study	VERB
bptjm-46	28	7	adipocytokines	adipocytokine	NOUN
bptjm-46	28	8	are	be	AUX
bptjm-46	28	9	adiponectin	adiponectin	NOUN
bptjm-46	28	10	and	and	CCONJ
bptjm-46	28	11	leptin	leptin	NOUN
bptjm-46	28	12	.	.	PUNCT
bptjm-46	29	1	while	while	SCONJ
bptjm-46	29	2	both	both	PRON
bptjm-46	29	3	are	be	AUX
bptjm-46	29	4	heavily	heavily	ADV
bptjm-46	29	5	impacted	impact	VERB
bptjm-46	29	6	by	by	ADP
bptjm-46	29	7	the	the	DET
bptjm-46	29	8	change	change	NOUN
bptjm-46	29	9	in	in	ADP
bptjm-46	29	10	adiposity	adiposity	NOUN
bptjm-46	29	11	,	,	PUNCT
bptjm-46	29	12	the	the	DET
bptjm-46	29	13	change	change	NOUN
bptjm-46	29	14	in	in	ADP
bptjm-46	29	15	concentration	concentration	NOUN
bptjm-46	29	16	and	and	CCONJ
bptjm-46	29	17	distribution	distribution	NOUN
bptjm-46	29	18	of	of	ADP
bptjm-46	29	19	adipose	adipose	ADJ
bptjm-46	29	20	tissue4	tissue4	NOUN
bptjm-46	29	21	impacts	impact	NOUN
bptjm-46	29	22	the	the	DET
bptjm-46	29	23	body	body	NOUN
bptjm-46	29	24	’s	’s	PART
bptjm-46	29	25	response	response	NOUN
bptjm-46	29	26	to	to	ADP
bptjm-46	29	27	metabolites	metabolite	NOUN
bptjm-46	29	28	.	.	PUNCT
bptjm-46	30	1	adiponectin	adiponectin	NOUN
bptjm-46	30	2	is	be	AUX
bptjm-46	30	3	secreted	secrete	VERB
bptjm-46	30	4	by	by	ADP
bptjm-46	30	5	adipose	adipose	ADJ
bptjm-46	30	6	tissue	tissue	NOUN
bptjm-46	30	7	into	into	ADP
bptjm-46	30	8	the	the	DET
bptjm-46	30	9	bloodstream	bloodstream	NOUN
bptjm-46	30	10	,	,	PUNCT
bptjm-46	30	11	with	with	ADP
bptjm-46	30	12	a	a	DET
bptjm-46	30	13	function	function	NOUN
bptjm-46	30	14	of	of	ADP
bptjm-46	30	15	mediating	mediate	VERB
bptjm-46	30	16	glucose	glucose	NOUN
bptjm-46	30	17	metabolism	metabolism	NOUN
bptjm-46	30	18	and	and	CCONJ
bptjm-46	30	19	fatty	fatty	NOUN
bptjm-46	30	20	acid	acid	NOUN
bptjm-46	30	21	oxidation	oxidation	NOUN
bptjm-46	30	22	process5	process5	NOUN
bptjm-46	30	23	.	.	PUNCT
bptjm-46	31	1	study	study	NOUN
bptjm-46	31	2	conducted	conduct	VERB
bptjm-46	31	3	by	by	ADP
bptjm-46	31	4	reneau	reneau	PROPN
bptjm-46	31	5	,	,	PUNCT
bptjm-46	31	6	james	james	PROPN
bptjm-46	31	7	et	et	PROPN
bptjm-46	31	8	al	al	PROPN
bptjm-46	31	9	reveals	reveal	VERB
bptjm-46	31	10	that	that	SCONJ
bptjm-46	31	11	the	the	DET
bptjm-46	31	12	linkage	linkage	NOUN
bptjm-46	31	13	between	between	ADP
bptjm-46	31	14	the	the	DET
bptjm-46	31	15	accumulation	accumulation	NOUN
bptjm-46	31	16	of	of	ADP
bptjm-46	31	17	adipose	adipose	ADJ
bptjm-46	31	18	tissue	tissue	NOUN
bptjm-46	31	19	and	and	CCONJ
bptjm-46	31	20	secretion	secretion	NOUN
bptjm-46	31	21	of	of	ADP
bptjm-46	31	22	adiponectin	adiponectin	NOUN
bptjm-46	31	23	shows	show	VERB
bptjm-46	31	24	a	a	DET
bptjm-46	31	25	negative	negative	ADJ
bptjm-46	31	26	correlation6	correlation6	NOUN
bptjm-46	31	27	.	.	PUNCT
bptjm-46	32	1	therefore	therefore	ADV
bptjm-46	32	2	,	,	PUNCT
bptjm-46	32	3	the	the	DET
bptjm-46	32	4	increased	increase	VERB
bptjm-46	32	5	adiposity	adiposity	NOUN
bptjm-46	32	6	inhibits	inhibit	VERB
bptjm-46	32	7	the	the	DET
bptjm-46	32	8	production	production	NOUN
bptjm-46	32	9	of	of	ADP
bptjm-46	32	10	adiponectin	adiponectin	NOUN
bptjm-46	32	11	,	,	PUNCT
bptjm-46	32	12	disabling	disable	VERB
bptjm-46	32	13	its	its	PRON
bptjm-46	32	14	function	function	NOUN
bptjm-46	32	15	to	to	PART
bptjm-46	32	16	regulate	regulate	VERB
bptjm-46	32	17	gluconeogenesis6	gluconeogenesis6	NOUN
bptjm-46	32	18	.	.	PUNCT
bptjm-46	33	1	leptin	leptin	PROPN
bptjm-46	33	2	,	,	PUNCT
bptjm-46	33	3	another	another	DET
bptjm-46	33	4	cytokine	cytokine	NOUN
bptjm-46	33	5	secreted	secrete	VERB
bptjm-46	33	6	by	by	ADP
bptjm-46	33	7	adipose	adipose	ADJ
bptjm-46	33	8	tissue	tissue	NOUN
bptjm-46	33	9	,	,	PUNCT
bptjm-46	33	10	has	have	VERB
bptjm-46	33	11	an	an	DET
bptjm-46	33	12	opposite	opposite	ADJ
bptjm-46	33	13	e	e	NOUN
bptjm-46	33	14	�	�	NOUN
bptjm-46	33	15	ect	ect	VERB
bptjm-46	33	16	to	to	AUX
bptjm-46	33	17	adiponectin	adiponectin	NOUN
bptjm-46	33	18	.	.	PUNCT
bptjm-46	34	1	acting	act	VERB
bptjm-46	34	2	on	on	ADP
bptjm-46	34	3	the	the	DET
bptjm-46	34	4	central	central	ADJ
bptjm-46	34	5	nervous	nervous	ADJ
bptjm-46	34	6	system	system	NOUN
bptjm-46	34	7	,	,	PUNCT
bptjm-46	34	8	namely	namely	ADV
bptjm-46	34	9	the	the	DET
bptjm-46	34	10	hypothalamus7,8	hypothalamus7,8	PROPN
bptjm-46	34	11	,	,	PUNCT
bptjm-46	34	12	leptin	leptin	NOUN
bptjm-46	34	13	serves	serve	VERB
bptjm-46	34	14	to	to	PART
bptjm-46	34	15	decrease	decrease	VERB
bptjm-46	34	16	the	the	DET
bptjm-46	34	17	sense	sense	NOUN
bptjm-46	34	18	of	of	ADP
bptjm-46	34	19	hunger	hunger	NOUN
bptjm-46	34	20	while	while	SCONJ
bptjm-46	34	21	inducing	induce	VERB
bptjm-46	34	22	berkeley	berkeley	PROPN
bptjm-46	34	23	pharma	pharma	PROPN
bptjm-46	34	24	tech	tech	NOUN
bptjm-46	34	25	journal	journal	NOUN
bptjm-46	34	26	of	of	ADP
bptjm-46	34	27	medicine	medicine	NOUN
bptjm-46	34	28	|	|	ADV
bptjm-46	34	29	103	103	NUM
bptjm-46	34	30	the	the	DET
bptjm-46	34	31	activity	activity	NOUN
bptjm-46	34	32	of	of	ADP
bptjm-46	34	33	beta	beta	ADJ
bptjm-46	34	34	pancreatic	pancreatic	ADJ
bptjm-46	34	35	cells	cell	NOUN
bptjm-46	34	36	that	that	PRON
bptjm-46	34	37	produce	produce	VERB
bptjm-46	34	38	insulin	insulin	NOUN
bptjm-46	34	39	.	.	PUNCT
bptjm-46	35	1	it	it	PRON
bptjm-46	35	2	is	be	AUX
bptjm-46	35	3	shown	show	VERB
bptjm-46	35	4	that	that	SCONJ
bptjm-46	35	5	leptin	leptin	NOUN
bptjm-46	35	6	production	production	NOUN
bptjm-46	35	7	is	be	AUX
bptjm-46	35	8	positively	positively	ADV
bptjm-46	35	9	correlated	correlate	VERB
bptjm-46	35	10	with	with	ADP
bptjm-46	35	11	the	the	DET
bptjm-46	35	12	increased	increase	VERB
bptjm-46	35	13	adiposity	adiposity	NOUN
bptjm-46	35	14	,	,	PUNCT
bptjm-46	35	15	with	with	ADP
bptjm-46	35	16	a	a	DET
bptjm-46	35	17	positive	positive	ADJ
bptjm-46	35	18	feedback	feedback	NOUN
bptjm-46	35	19	loop	loop	NOUN
bptjm-46	35	20	involving	involve	VERB
bptjm-46	35	21	increased	increase	VERB
bptjm-46	35	22	circulating	circulate	VERB
bptjm-46	35	23	insulin	insulin	NOUN
bptjm-46	35	24	and	and	CCONJ
bptjm-46	35	25	the	the	DET
bptjm-46	35	26	resulting	result	VERB
bptjm-46	35	27	increase	increase	NOUN
bptjm-46	35	28	of	of	ADP
bptjm-46	35	29	adipose	adipose	ADJ
bptjm-46	35	30	tissue	tissue	NOUN
bptjm-46	35	31	.	.	PUNCT
bptjm-46	36	1	both	both	PRON
bptjm-46	36	2	researched	research	VERB
bptjm-46	36	3	adipokines	adipokine	NOUN
bptjm-46	36	4	promote	promote	VERB
bptjm-46	36	5	the	the	DET
bptjm-46	36	6	risk	risk	NOUN
bptjm-46	36	7	of	of	ADP
bptjm-46	36	8	getting	get	VERB
bptjm-46	36	9	diabetes	diabetes	NOUN
bptjm-46	36	10	.	.	PUNCT
bptjm-46	37	1	furthermore	furthermore	ADV
bptjm-46	37	2	,	,	PUNCT
bptjm-46	37	3	insulin	insulin	NOUN
bptjm-46	37	4	also	also	ADV
bptjm-46	37	5	plays	play	VERB
bptjm-46	37	6	a	a	DET
bptjm-46	37	7	critical	critical	ADJ
bptjm-46	37	8	role	role	NOUN
bptjm-46	37	9	in	in	ADP
bptjm-46	37	10	the	the	DET
bptjm-46	37	11	hydrolyzation	hydrolyzation	NOUN
bptjm-46	37	12	of	of	ADP
bptjm-46	37	13	fatty	fatty	NOUN
bptjm-46	37	14	acid	acid	NOUN
bptjm-46	37	15	,	,	PUNCT
bptjm-46	37	16	which	which	PRON
bptjm-46	37	17	serves	serve	VERB
bptjm-46	37	18	to	to	PART
bptjm-46	37	19	increase	increase	VERB
bptjm-46	37	20	the	the	DET
bptjm-46	37	21	rate	rate	NOUN
bptjm-46	37	22	of	of	ADP
bptjm-46	37	23	glucose	glucose	NOUN
bptjm-46	37	24	uptake	uptake	ADJ
bptjm-46	37	25	and	and	CCONJ
bptjm-46	37	26	fatty	fatty	NOUN
bptjm-46	37	27	acid	acid	NOUN
bptjm-46	37	28	synthesis	synthesis	NOUN
bptjm-46	37	29	,	,	PUNCT
bptjm-46	37	30	as	as	ADV
bptjm-46	37	31	well	well	ADV
bptjm-46	37	32	as	as	ADP
bptjm-46	37	33	decrease	decrease	VERB
bptjm-46	37	34	the	the	DET
bptjm-46	37	35	rate	rate	NOUN
bptjm-46	37	36	of	of	ADP
bptjm-46	37	37	fatty	fatty	NOUN
bptjm-46	37	38	acid	acid	NOUN
bptjm-46	37	39	decomposition9	decomposition9	PROPN
bptjm-46	37	40	.	.	PUNCT
bptjm-46	38	1	the	the	DET
bptjm-46	38	2	tumor	tumor	NOUN
bptjm-46	38	3	,	,	PUNCT
bptjm-46	38	4	upon	upon	SCONJ
bptjm-46	38	5	receiving	receive	VERB
bptjm-46	38	6	bene	bene	NOUN
bptjm-46	38	7	�	�	PROPN
bptjm-46	38	8	cial	cial	ADJ
bptjm-46	38	9	signals	signal	NOUN
bptjm-46	38	10	from	from	ADP
bptjm-46	38	11	the	the	DET
bptjm-46	38	12	adipose	adipose	ADJ
bptjm-46	38	13	tissue	tissue	NOUN
bptjm-46	38	14	,	,	PUNCT
bptjm-46	38	15	also	also	ADV
bptjm-46	38	16	feeds	feed	VERB
bptjm-46	38	17	back	back	ADV
bptjm-46	38	18	with	with	ADP
bptjm-46	38	19	inhibitory	inhibitory	ADJ
bptjm-46	38	20	signals	signal	NOUN
bptjm-46	38	21	on	on	ADP
bptjm-46	38	22	the	the	DET
bptjm-46	38	23	decomposition	decomposition	NOUN
bptjm-46	38	24	of	of	ADP
bptjm-46	38	25	fats	fat	NOUN
bptjm-46	38	26	.	.	PUNCT
bptjm-46	39	1	therefore	therefore	ADV
bptjm-46	39	2	,	,	PUNCT
bptjm-46	39	3	a	a	DET
bptjm-46	39	4	positive	positive	ADJ
bptjm-46	39	5	feedback	feedback	NOUN
bptjm-46	39	6	loop	loop	NOUN
bptjm-46	39	7	is	be	AUX
bptjm-46	39	8	observed	observe	VERB
bptjm-46	39	9	among	among	ADP
bptjm-46	39	10	obesity	obesity	NOUN
bptjm-46	39	11	-	-	PUNCT
bptjm-46	39	12	high	high	ADJ
bptjm-46	39	13	blood	blood	NOUN
bptjm-46	39	14	insulin	insulin	NOUN
bptjm-46	39	15	-	-	PUNCT
bptjm-46	39	16	tumor	tumor	NOUN
bptjm-46	39	17	development	development	NOUN
bptjm-46	39	18	,	,	PUNCT
bptjm-46	39	19	as	as	SCONJ
bptjm-46	39	20	shown	show	VERB
bptjm-46	39	21	here	here	ADV
bptjm-46	39	22	in	in	ADP
bptjm-46	39	23	�	�	PROPN
bptjm-46	39	24	gure	gure	NOUN
bptjm-46	39	25	1	1	NUM
bptjm-46	39	26	.	.	PUNCT
bptjm-46	40	1	figure	figure	NOUN
bptjm-46	40	2	1	1	NUM
bptjm-46	40	3	.	.	PUNCT
bptjm-46	41	1	the	the	DET
bptjm-46	41	2	positive	positive	ADJ
bptjm-46	41	3	feedback	feedback	NOUN
bptjm-46	41	4	of	of	ADP
bptjm-46	41	5	adipose	adipose	ADJ
bptjm-46	41	6	tissue	tissue	NOUN
bptjm-46	41	7	accumulation	accumulation	NOUN
bptjm-46	41	8	and	and	CCONJ
bptjm-46	41	9	cancer	cancer	NOUN
bptjm-46	41	10	development	development	NOUN
bptjm-46	41	11	.	.	PUNCT
bptjm-46	42	1	for	for	ADP
bptjm-46	42	2	summary	summary	NOUN
bptjm-46	42	3	,	,	PUNCT
bptjm-46	42	4	the	the	DET
bptjm-46	42	5	abnormally	abnormally	ADV
bptjm-46	42	6	high	high	ADJ
bptjm-46	42	7	bmi	bmi	NOUN
bptjm-46	42	8	level	level	NOUN
bptjm-46	42	9	indicates	indicate	VERB
bptjm-46	42	10	the	the	DET
bptjm-46	42	11	obesity	obesity	NOUN
bptjm-46	42	12	level	level	NOUN
bptjm-46	42	13	of	of	ADP
bptjm-46	42	14	an	an	DET
bptjm-46	42	15	individual	individual	NOUN
bptjm-46	42	16	,	,	PUNCT
bptjm-46	42	17	resulting	result	VERB
bptjm-46	42	18	in	in	ADP
bptjm-46	42	19	the	the	DET
bptjm-46	42	20	�	�	PROPN
bptjm-46	42	21	uctuation	uctuation	NOUN
bptjm-46	42	22	of	of	ADP
bptjm-46	42	23	production	production	NOUN
bptjm-46	42	24	for	for	ADP
bptjm-46	42	25	critical	critical	ADJ
bptjm-46	42	26	metabolic	metabolic	NOUN
bptjm-46	42	27	regulators	regulator	NOUN
bptjm-46	42	28	,	,	PUNCT
bptjm-46	42	29	which	which	PRON
bptjm-46	42	30	leads	lead	VERB
bptjm-46	42	31	to	to	ADP
bptjm-46	42	32	the	the	DET
bptjm-46	42	33	increasing	increase	VERB
bptjm-46	42	34	level	level	NOUN
bptjm-46	42	35	of	of	ADP
bptjm-46	42	36	insulin	insulin	NOUN
bptjm-46	42	37	circulating	circulate	VERB
bptjm-46	42	38	in	in	ADP
bptjm-46	42	39	the	the	DET
bptjm-46	42	40	body	body	NOUN
bptjm-46	42	41	and	and	CCONJ
bptjm-46	42	42	subsequently	subsequently	ADV
bptjm-46	42	43	,	,	PUNCT
bptjm-46	42	44	will	will	AUX
bptjm-46	42	45	cause	cause	VERB
bptjm-46	42	46	type	type	NOUN
bptjm-46	42	47	ii	ii	NOUN
bptjm-46	42	48	diabetes	diabetes	NOUN
bptjm-46	42	49	mellitus	mellitus	NOUN
bptjm-46	42	50	by	by	ADP
bptjm-46	42	51	inducing	induce	VERB
bptjm-46	42	52	insulin	insulin	NOUN
bptjm-46	42	53	resistance	resistance	NOUN
bptjm-46	42	54	.	.	PUNCT
bptjm-46	43	1	over	over	ADP
bptjm-46	43	2	time	time	NOUN
bptjm-46	43	3	,	,	PUNCT
bptjm-46	43	4	the	the	DET
bptjm-46	43	5	disturbance	disturbance	NOUN
bptjm-46	43	6	of	of	ADP
bptjm-46	43	7	homeostasis	homeostasis	NOUN
bptjm-46	43	8	can	can	AUX
bptjm-46	43	9	generate	generate	VERB
bptjm-46	43	10	enough	enough	ADJ
bptjm-46	43	11	energy	energy	NOUN
bptjm-46	43	12	to	to	PART
bptjm-46	43	13	promote	promote	VERB
bptjm-46	43	14	the	the	DET
bptjm-46	43	15	growth	growth	NOUN
bptjm-46	43	16	of	of	ADP
bptjm-46	43	17	cancer	cancer	NOUN
bptjm-46	43	18	,	,	PUNCT
bptjm-46	43	19	particularly	particularly	ADV
bptjm-46	43	20	in	in	ADP
bptjm-46	43	21	organs	organ	NOUN
bptjm-46	43	22	with	with	ADP
bptjm-46	43	23	high	high	ADJ
bptjm-46	43	24	concentrations	concentration	NOUN
bptjm-46	43	25	of	of	ADP
bptjm-46	43	26	adipose	adipose	ADJ
bptjm-46	43	27	tissue	tissue	NOUN
bptjm-46	43	28	.	.	PUNCT
bptjm-46	44	1	3	3	X
bptjm-46	44	2	.	.	X
bptjm-46	44	3	type	type	NOUN
bptjm-46	44	4	ii	ii	PROPN
bptjm-46	44	5	diabetes	diabetes	NOUN
bptjm-46	44	6	mellitus	mellitus	NOUN
bptjm-46	44	7	(	(	PUNCT
bptjm-46	44	8	t2	t2	NOUN
bptjm-46	44	9	dm	dm	PROPN
bptjm-46	44	10	)	)	PUNCT
bptjm-46	44	11	and	and	CCONJ
bptjm-46	44	12	its	its	PRON
bptjm-46	44	13	correlation	correlation	NOUN
bptjm-46	44	14	to	to	ADP
bptjm-46	44	15	cancer	cancer	NOUN
bptjm-46	44	16	progression	progression	NOUN
bptjm-46	44	17	berkeley	berkeley	PROPN
bptjm-46	44	18	pharma	pharma	PROPN
bptjm-46	44	19	tech	tech	NOUN
bptjm-46	44	20	journal	journal	NOUN
bptjm-46	44	21	of	of	ADP
bptjm-46	44	22	medicine	medicine	NOUN
bptjm-46	44	23	|	|	ADV
bptjm-46	44	24	104	104	NUM
bptjm-46	44	25	the	the	DET
bptjm-46	44	26	compilation	compilation	NOUN
bptjm-46	44	27	of	of	ADP
bptjm-46	44	28	the	the	DET
bptjm-46	44	29	mentioned	mention	VERB
bptjm-46	44	30	negative	negative	ADJ
bptjm-46	44	31	impacts	impact	NOUN
bptjm-46	44	32	from	from	ADP
bptjm-46	44	33	the	the	DET
bptjm-46	44	34	previous	previous	ADJ
bptjm-46	44	35	section	section	NOUN
bptjm-46	44	36	will	will	AUX
bptjm-46	44	37	lead	lead	VERB
bptjm-46	44	38	to	to	ADP
bptjm-46	44	39	the	the	DET
bptjm-46	44	40	development	development	NOUN
bptjm-46	44	41	of	of	ADP
bptjm-46	44	42	t2	t2	PROPN
bptjm-46	44	43	dm	dm	PROPN
bptjm-46	44	44	.	.	PUNCT
bptjm-46	44	45	establishment	establishment	NOUN
bptjm-46	44	46	of	of	ADP
bptjm-46	44	47	insulin	insulin	NOUN
bptjm-46	44	48	resistance	resistance	NOUN
bptjm-46	44	49	(	(	PUNCT
bptjm-46	44	50	ir	ir	NOUN
bptjm-46	44	51	)	)	PUNCT
bptjm-46	44	52	by	by	ADP
bptjm-46	44	53	tissues	tissue	NOUN
bptjm-46	44	54	will	will	AUX
bptjm-46	44	55	be	be	AUX
bptjm-46	44	56	disabled	disable	VERB
bptjm-46	44	57	to	to	PART
bptjm-46	44	58	respond	respond	VERB
bptjm-46	44	59	normally	normally	ADV
bptjm-46	44	60	to	to	ADP
bptjm-46	44	61	the	the	DET
bptjm-46	44	62	hormone	hormone	NOUN
bptjm-46	44	63	insulin	insulin	NOUN
bptjm-46	44	64	or	or	CCONJ
bptjm-46	44	65	downregulate	downregulate	NOUN
bptjm-46	44	66	insulin	insulin	NOUN
bptjm-46	44	67	receptors	receptor	NOUN
bptjm-46	44	68	in	in	ADP
bptjm-46	44	69	response	response	NOUN
bptjm-46	44	70	to	to	PART
bptjm-46	44	71	hyperinsulinemia10	hyperinsulinemia10	VERB
bptjm-46	44	72	.	.	PUNCT
bptjm-46	45	1	the	the	DET
bptjm-46	45	2	detailed	detailed	ADJ
bptjm-46	45	3	development	development	NOUN
bptjm-46	45	4	of	of	ADP
bptjm-46	45	5	ir	ir	PROPN
bptjm-46	45	6	remains	remain	VERB
bptjm-46	45	7	unclear	unclear	ADJ
bptjm-46	45	8	,	,	PUNCT
bptjm-46	45	9	but	but	CCONJ
bptjm-46	45	10	the	the	DET
bptjm-46	45	11	hypothesis	hypothesis	NOUN
bptjm-46	45	12	is	be	AUX
bptjm-46	45	13	that	that	SCONJ
bptjm-46	45	14	decrease	decrease	NOUN
bptjm-46	45	15	in	in	ADP
bptjm-46	45	16	insulin	insulin	NOUN
bptjm-46	45	17	sensitivity	sensitivity	NOUN
bptjm-46	45	18	with	with	ADP
bptjm-46	45	19	adjustments	adjustment	NOUN
bptjm-46	45	20	in	in	ADP
bptjm-46	45	21	the	the	DET
bptjm-46	45	22	pi3k	pi3k	PROPN
bptjm-46	45	23	/	/	SYM
bptjm-46	45	24	akt	akt	PROPN
bptjm-46	45	25	/	/	SYM
bptjm-46	45	26	mtor	mtor	PROPN
bptjm-46	45	27	signaling	signal	VERB
bptjm-46	45	28	pathway11	pathway11	NOUN
bptjm-46	45	29	.	.	PUNCT
bptjm-46	46	1	hyperinsulinemia	hyperinsulinemia	NOUN
bptjm-46	46	2	boosts	boost	VERB
bptjm-46	46	3	the	the	DET
bptjm-46	46	4	advancement	advancement	NOUN
bptjm-46	46	5	of	of	ADP
bptjm-46	46	6	cancer	cancer	NOUN
bptjm-46	46	7	by	by	ADP
bptjm-46	46	8	providing	provide	VERB
bptjm-46	46	9	access	access	NOUN
bptjm-46	46	10	to	to	ADP
bptjm-46	46	11	excess	excess	ADJ
bptjm-46	46	12	glucose	glucose	NOUN
bptjm-46	46	13	from	from	ADP
bptjm-46	46	14	the	the	DET
bptjm-46	46	15	bloodstream12	bloodstream12	NOUN
bptjm-46	46	16	.	.	PUNCT
bptjm-46	47	1	normal	normal	ADJ
bptjm-46	47	2	functioning	functioning	ADJ
bptjm-46	47	3	cells	cell	NOUN
bptjm-46	47	4	,	,	PUNCT
bptjm-46	47	5	upon	upon	SCONJ
bptjm-46	47	6	receiving	receive	VERB
bptjm-46	47	7	glucose	glucose	NOUN
bptjm-46	47	8	,	,	PUNCT
bptjm-46	47	9	will	will	AUX
bptjm-46	47	10	degrade	degrade	VERB
bptjm-46	47	11	it	it	PRON
bptjm-46	47	12	for	for	ADP
bptjm-46	47	13	energy	energy	NOUN
bptjm-46	47	14	with	with	ADP
bptjm-46	47	15	the	the	DET
bptjm-46	47	16	assistance	assistance	NOUN
bptjm-46	47	17	of	of	ADP
bptjm-46	47	18	oxygen	oxygen	NOUN
bptjm-46	47	19	in	in	ADP
bptjm-46	47	20	the	the	DET
bptjm-46	47	21	process	process	NOUN
bptjm-46	47	22	of	of	ADP
bptjm-46	47	23	glycolysis	glycolysis	NOUN
bptjm-46	47	24	,	,	PUNCT
bptjm-46	47	25	citric	citric	ADJ
bptjm-46	47	26	acid	acid	NOUN
bptjm-46	47	27	cycle	cycle	NOUN
bptjm-46	47	28	,	,	PUNCT
bptjm-46	47	29	and	and	CCONJ
bptjm-46	47	30	oxidative	oxidative	ADJ
bptjm-46	47	31	phosphorylation	phosphorylation	NOUN
bptjm-46	47	32	,	,	PUNCT
bptjm-46	47	33	producing	produce	VERB
bptjm-46	47	34	approximately	approximately	ADV
bptjm-46	47	35	34	34	NUM
bptjm-46	47	36	atp	atp	NOUN
bptjm-46	47	37	per	per	ADP
bptjm-46	47	38	glucose	glucose	NOUN
bptjm-46	47	39	used13	used13	NOUN
bptjm-46	47	40	.	.	PUNCT
bptjm-46	48	1	however	however	ADV
bptjm-46	48	2	,	,	PUNCT
bptjm-46	48	3	during	during	ADP
bptjm-46	48	4	the	the	DET
bptjm-46	48	5	pre	pre	ADJ
bptjm-46	48	6	-	-	ADJ
bptjm-46	48	7	malignant	malignant	ADJ
bptjm-46	48	8	expansion	expansion	NOUN
bptjm-46	48	9	stage	stage	NOUN
bptjm-46	48	10	of	of	ADP
bptjm-46	48	11	tumor	tumor	NOUN
bptjm-46	48	12	,	,	PUNCT
bptjm-46	48	13	the	the	DET
bptjm-46	48	14	development	development	NOUN
bptjm-46	48	15	of	of	ADP
bptjm-46	48	16	peripheral	peripheral	ADJ
bptjm-46	48	17	tumor	tumor	NOUN
bptjm-46	48	18	microenvironment	microenvironment	NOUN
bptjm-46	48	19	(	(	PUNCT
bptjm-46	48	20	tme	tme	NOUN
bptjm-46	48	21	)	)	PUNCT
bptjm-46	48	22	will	will	AUX
bptjm-46	48	23	separate	separate	VERB
bptjm-46	48	24	the	the	DET
bptjm-46	48	25	interior	interior	NOUN
bptjm-46	48	26	of	of	ADP
bptjm-46	48	27	tumor	tumor	NOUN
bptjm-46	48	28	cells	cell	NOUN
bptjm-46	48	29	farther	far	ADV
bptjm-46	48	30	away	away	ADV
bptjm-46	48	31	from	from	ADP
bptjm-46	48	32	the	the	DET
bptjm-46	48	33	local	local	ADJ
bptjm-46	48	34	bloodstream14	bloodstream14	NOUN
bptjm-46	48	35	,	,	PUNCT
bptjm-46	48	36	which	which	PRON
bptjm-46	48	37	is	be	AUX
bptjm-46	48	38	the	the	DET
bptjm-46	48	39	carrier	carrier	NOUN
bptjm-46	48	40	of	of	ADP
bptjm-46	48	41	oxygen	oxygen	NOUN
bptjm-46	48	42	-	-	PUNCT
bptjm-46	48	43	rich	rich	ADJ
bptjm-46	48	44	hemoglobin	hemoglobin	NOUN
bptjm-46	48	45	.	.	PUNCT
bptjm-46	49	1	the	the	DET
bptjm-46	49	2	result	result	NOUN
bptjm-46	49	3	of	of	ADP
bptjm-46	49	4	this	this	DET
bptjm-46	49	5	isolation	isolation	NOUN
bptjm-46	49	6	is	be	AUX
bptjm-46	49	7	the	the	DET
bptjm-46	49	8	leveled	level	VERB
bptjm-46	49	9	average	average	ADJ
bptjm-46	49	10	partial	partial	ADJ
bptjm-46	49	11	pressure	pressure	NOUN
bptjm-46	49	12	of	of	ADP
bptjm-46	49	13	oxygen	oxygen	NOUN
bptjm-46	49	14	in	in	ADP
bptjm-46	49	15	tme	tme	NOUN
bptjm-46	49	16	around	around	ADP
bptjm-46	49	17	5	5	NUM
bptjm-46	49	18	mmhg	mmhg	NOUN
bptjm-46	49	19	,	,	PUNCT
bptjm-46	49	20	which	which	PRON
bptjm-46	49	21	is	be	AUX
bptjm-46	49	22	only	only	ADV
bptjm-46	49	23	12.5	12.5	NUM
bptjm-46	49	24	%	%	NOUN
bptjm-46	49	25	in	in	ADP
bptjm-46	49	26	average	average	NOUN
bptjm-46	49	27	of	of	ADP
bptjm-46	49	28	the	the	DET
bptjm-46	49	29	venous	venous	ADJ
bptjm-46	49	30	oxygen	oxygen	NOUN
bptjm-46	49	31	pressure15	pressure15	NOUN
bptjm-46	49	32	.	.	PUNCT
bptjm-46	50	1	this	this	DET
bptjm-46	50	2	shift	shift	NOUN
bptjm-46	50	3	of	of	ADP
bptjm-46	50	4	oxygen	oxygen	NOUN
bptjm-46	50	5	level	level	NOUN
bptjm-46	50	6	disallows	disallow	VERB
bptjm-46	50	7	cancer	cancer	NOUN
bptjm-46	50	8	tissue	tissue	NOUN
bptjm-46	50	9	to	to	PART
bptjm-46	50	10	utilize	utilize	VERB
bptjm-46	50	11	oxygen	oxygen	NOUN
bptjm-46	50	12	for	for	ADP
bptjm-46	50	13	the	the	DET
bptjm-46	50	14	mitochondrial	mitochondrial	ADJ
bptjm-46	50	15	respiration	respiration	NOUN
bptjm-46	50	16	process	process	NOUN
bptjm-46	50	17	and	and	CCONJ
bptjm-46	50	18	instead	instead	ADV
bptjm-46	50	19	,	,	PUNCT
bptjm-46	50	20	it	it	PRON
bptjm-46	50	21	switches	switch	VERB
bptjm-46	50	22	its	its	PRON
bptjm-46	50	23	dependence	dependence	NOUN
bptjm-46	50	24	for	for	ADP
bptjm-46	50	25	energy	energy	NOUN
bptjm-46	50	26	to	to	ADP
bptjm-46	50	27	the	the	DET
bptjm-46	50	28	warburg	warburg	PROPN
bptjm-46	50	29	e	e	NOUN
bptjm-46	50	30	�	�	PROPN
bptjm-46	50	31	ect	ect	VERB
bptjm-46	50	32	,	,	PUNCT
bptjm-46	50	33	the	the	DET
bptjm-46	50	34	metabolic	metabolic	NOUN
bptjm-46	50	35	reprogramming	reprogramme	VERB
bptjm-46	50	36	e	e	NOUN
bptjm-46	50	37	�	�	NOUN
bptjm-46	50	38	ect	ect	VERB
bptjm-46	50	39	done	do	VERB
bptjm-46	50	40	by	by	ADP
bptjm-46	50	41	tumor	tumor	NOUN
bptjm-46	50	42	cells	cell	NOUN
bptjm-46	50	43	to	to	PART
bptjm-46	50	44	rely	rely	VERB
bptjm-46	50	45	on	on	ADP
bptjm-46	50	46	the	the	DET
bptjm-46	50	47	energy	energy	NOUN
bptjm-46	50	48	provided	provide	VERB
bptjm-46	50	49	by	by	ADP
bptjm-46	50	50	aerobic	aerobic	ADJ
bptjm-46	50	51	glycolysis	glycolysis	NOUN
bptjm-46	50	52	.	.	PUNCT
bptjm-46	51	1	this	this	PRON
bptjm-46	51	2	is	be	AUX
bptjm-46	51	3	only	only	ADV
bptjm-46	51	4	e	e	X
bptjm-46	51	5	�	�	NOUN
bptjm-46	51	6	ective	ective	ADJ
bptjm-46	51	7	when	when	SCONJ
bptjm-46	51	8	there	there	PRON
bptjm-46	51	9	is	be	VERB
bptjm-46	51	10	an	an	DET
bptjm-46	51	11	excessive	excessive	ADJ
bptjm-46	51	12	supply	supply	NOUN
bptjm-46	51	13	of	of	ADP
bptjm-46	51	14	glucose	glucose	NOUN
bptjm-46	51	15	and	and	CCONJ
bptjm-46	51	16	an	an	DET
bptjm-46	51	17	anaerobic	anaerobic	NOUN
bptjm-46	51	18	environment	environment	NOUN
bptjm-46	51	19	,	,	PUNCT
bptjm-46	51	20	for	for	ADP
bptjm-46	51	21	the	the	DET
bptjm-46	51	22	production	production	NOUN
bptjm-46	51	23	of	of	ADP
bptjm-46	51	24	energy	energy	NOUN
bptjm-46	51	25	is	be	AUX
bptjm-46	51	26	only	only	ADV
bptjm-46	51	27	4	4	NUM
bptjm-46	51	28	atp	atp	NOUN
bptjm-46	51	29	per	per	ADP
bptjm-46	51	30	glucose	glucose	NOUN
bptjm-46	51	31	consumed	consume	VERB
bptjm-46	51	32	,	,	PUNCT
bptjm-46	51	33	rather	rather	ADV
bptjm-46	51	34	ine	ine	PROPN
bptjm-46	51	35	�	�	PROPN
bptjm-46	51	36	cient	cient	PROPN
bptjm-46	51	37	compared	compare	VERB
bptjm-46	51	38	to	to	ADP
bptjm-46	51	39	the	the	DET
bptjm-46	51	40	normal	normal	ADJ
bptjm-46	51	41	process16	process16	X
bptjm-46	51	42	.	.	PUNCT
bptjm-46	52	1	therefore	therefore	ADV
bptjm-46	52	2	,	,	PUNCT
bptjm-46	52	3	the	the	DET
bptjm-46	52	4	t2	t2	NOUN
bptjm-46	52	5	dm	dm	NOUN
bptjm-46	52	6	with	with	ADP
bptjm-46	52	7	its	its	PRON
bptjm-46	52	8	in	in	ADP
bptjm-46	52	9	�	�	NOUN
bptjm-46	52	10	uence	uence	NOUN
bptjm-46	52	11	on	on	ADP
bptjm-46	52	12	tissues	tissue	NOUN
bptjm-46	52	13	incapable	incapable	ADJ
bptjm-46	52	14	of	of	ADP
bptjm-46	52	15	utilizing	utilize	VERB
bptjm-46	52	16	glucose	glucose	NOUN
bptjm-46	52	17	e	e	NOUN
bptjm-46	52	18	�	�	NOUN
bptjm-46	52	19	ciently	ciently	ADJ
bptjm-46	52	20	,	,	PUNCT
bptjm-46	52	21	the	the	DET
bptjm-46	52	22	extra	extra	ADJ
bptjm-46	52	23	circulating	circulate	VERB
bptjm-46	52	24	glucose	glucose	NOUN
bptjm-46	52	25	in	in	ADP
bptjm-46	52	26	the	the	DET
bptjm-46	52	27	bloodstream	bloodstream	NOUN
bptjm-46	52	28	will	will	AUX
bptjm-46	52	29	be	be	AUX
bptjm-46	52	30	recruited	recruit	VERB
bptjm-46	52	31	and	and	CCONJ
bptjm-46	52	32	made	make	VERB
bptjm-46	52	33	use	use	NOUN
bptjm-46	52	34	of	of	ADP
bptjm-46	52	35	by	by	ADP
bptjm-46	52	36	the	the	DET
bptjm-46	52	37	tumor	tumor	NOUN
bptjm-46	52	38	complex17	complex17	PROPN
bptjm-46	52	39	.	.	PUNCT
bptjm-46	53	1	on	on	ADP
bptjm-46	53	2	the	the	DET
bptjm-46	53	3	other	other	ADJ
bptjm-46	53	4	hand	hand	NOUN
bptjm-46	53	5	,	,	PUNCT
bptjm-46	53	6	t2	t2	PROPN
bptjm-46	53	7	dm	dm	PRON
bptjm-46	53	8	also	also	ADV
bptjm-46	53	9	provides	provide	VERB
bptjm-46	53	10	conveniences	convenience	NOUN
bptjm-46	53	11	for	for	ADP
bptjm-46	53	12	the	the	DET
bptjm-46	53	13	progression	progression	NOUN
bptjm-46	53	14	of	of	ADP
bptjm-46	53	15	cancer	cancer	NOUN
bptjm-46	53	16	by	by	ADP
bptjm-46	53	17	the	the	DET
bptjm-46	53	18	hyper	hyper	ADV
bptjm-46	53	19	-	-	ADJ
bptjm-46	53	20	expressed	express	VERB
bptjm-46	53	21	insulin	insulin	NOUN
bptjm-46	53	22	.	.	PUNCT
bptjm-46	54	1	insulin	insulin	NOUN
bptjm-46	54	2	serves	serve	VERB
bptjm-46	54	3	as	as	ADP
bptjm-46	54	4	a	a	DET
bptjm-46	54	5	mitogen	mitogen	NOUN
bptjm-46	54	6	in	in	ADP
bptjm-46	54	7	the	the	DET
bptjm-46	54	8	human	human	ADJ
bptjm-46	54	9	body18	body18	NOUN
bptjm-46	54	10	.	.	PUNCT
bptjm-46	55	1	with	with	ADP
bptjm-46	55	2	high	high	ADJ
bptjm-46	55	3	levels	level	NOUN
bptjm-46	55	4	of	of	ADP
bptjm-46	55	5	insulin	insulin	NOUN
bptjm-46	55	6	expressed	express	VERB
bptjm-46	55	7	,	,	PUNCT
bptjm-46	55	8	cells	cell	NOUN
bptjm-46	55	9	are	be	AUX
bptjm-46	55	10	excited	excite	VERB
bptjm-46	55	11	by	by	ADP
bptjm-46	55	12	the	the	DET
bptjm-46	55	13	signal	signal	NOUN
bptjm-46	55	14	from	from	ADP
bptjm-46	55	15	mitogens	mitogen	NOUN
bptjm-46	55	16	to	to	PART
bptjm-46	55	17	proceed	proceed	VERB
bptjm-46	55	18	with	with	ADP
bptjm-46	55	19	more	more	ADJ
bptjm-46	55	20	mitosis	mitosis	NOUN
bptjm-46	55	21	.	.	PUNCT
bptjm-46	56	1	besides	besides	SCONJ
bptjm-46	56	2	insulin	insulin	NOUN
bptjm-46	56	3	,	,	PUNCT
bptjm-46	56	4	insulin	insulin	NOUN
bptjm-46	56	5	-	-	PUNCT
bptjm-46	56	6	like	like	ADJ
bptjm-46	56	7	growth	growth	NOUN
bptjm-46	56	8	factor	factor	NOUN
bptjm-46	56	9	1	1	NUM
bptjm-46	56	10	(	(	PUNCT
bptjm-46	56	11	igf1	igf1	PROPN
bptjm-46	56	12	)	)	PUNCT
bptjm-46	56	13	also	also	ADV
bptjm-46	56	14	serves	serve	VERB
bptjm-46	56	15	as	as	ADP
bptjm-46	56	16	an	an	DET
bptjm-46	56	17	important	important	ADJ
bptjm-46	56	18	mitogen	mitogen	NOUN
bptjm-46	56	19	.	.	PUNCT
bptjm-46	57	1	however	however	ADV
bptjm-46	57	2	,	,	PUNCT
bptjm-46	57	3	igf1	igf1	PROPN
bptjm-46	57	4	is	be	AUX
bptjm-46	57	5	not	not	PART
bptjm-46	57	6	induced	induce	VERB
bptjm-46	57	7	by	by	ADP
bptjm-46	57	8	the	the	DET
bptjm-46	57	9	increased	increase	VERB
bptjm-46	57	10	level	level	NOUN
bptjm-46	57	11	of	of	ADP
bptjm-46	57	12	blood	blood	NOUN
bptjm-46	57	13	glucose	glucose	NOUN
bptjm-46	57	14	,	,	PUNCT
bptjm-46	57	15	but	but	CCONJ
bptjm-46	57	16	the	the	DET
bptjm-46	57	17	excess	excess	ADJ
bptjm-46	57	18	circulating	circulate	VERB
bptjm-46	57	19	insulin	insulin	NOUN
bptjm-46	57	20	serves	serve	VERB
bptjm-46	57	21	to	to	PART
bptjm-46	57	22	compete	compete	VERB
bptjm-46	57	23	with	with	ADP
bptjm-46	57	24	igf	igf	PROPN
bptjm-46	57	25	for	for	ADP
bptjm-46	57	26	the	the	DET
bptjm-46	57	27	constant	constant	ADJ
bptjm-46	57	28	amount	amount	NOUN
bptjm-46	57	29	of	of	ADP
bptjm-46	57	30	igf	igf	PROPN
bptjm-46	57	31	binding	binding	PROPN
bptjm-46	57	32	berkeley	berkeley	PROPN
bptjm-46	57	33	pharma	pharma	PROPN
bptjm-46	57	34	tech	tech	NOUN
bptjm-46	57	35	journal	journal	NOUN
bptjm-46	57	36	of	of	ADP
bptjm-46	57	37	medicine	medicine	NOUN
bptjm-46	57	38	|	|	ADV
bptjm-46	57	39	105	105	NUM
bptjm-46	57	40	protein	protein	NOUN
bptjm-46	57	41	3	3	NUM
bptjm-46	57	42	(	(	PUNCT
bptjm-46	57	43	igfbp3	igfbp3	NOUN
bptjm-46	57	44	)	)	PUNCT
bptjm-46	57	45	.	.	PUNCT
bptjm-46	58	1	as	as	SCONJ
bptjm-46	58	2	igf1	igf1	PROPN
bptjm-46	58	3	is	be	AUX
bptjm-46	58	4	a	a	DET
bptjm-46	58	5	mitogen	mitogen	NOUN
bptjm-46	58	6	as	as	ADV
bptjm-46	58	7	well	well	ADV
bptjm-46	58	8	,	,	PUNCT
bptjm-46	58	9	the	the	DET
bptjm-46	58	10	imbalance	imbalance	NOUN
bptjm-46	58	11	between	between	ADP
bptjm-46	58	12	igf1	igf1	PROPN
bptjm-46	58	13	-	-	PUNCT
bptjm-46	58	14	igfbp3	igfbp3	NOUN
bptjm-46	58	15	ratio	ratio	NOUN
bptjm-46	58	16	leads	lead	VERB
bptjm-46	58	17	to	to	ADP
bptjm-46	58	18	excess	excess	ADJ
bptjm-46	58	19	proliferation	proliferation	NOUN
bptjm-46	58	20	of	of	ADP
bptjm-46	58	21	cancer	cancer	NOUN
bptjm-46	58	22	cells	cell	NOUN
bptjm-46	58	23	.	.	PUNCT
bptjm-46	59	1	on	on	ADP
bptjm-46	59	2	top	top	NOUN
bptjm-46	59	3	of	of	ADP
bptjm-46	59	4	that	that	PRON
bptjm-46	59	5	,	,	PUNCT
bptjm-46	59	6	igfbp3	igfbp3	NOUN
bptjm-46	59	7	is	be	AUX
bptjm-46	59	8	considered	consider	VERB
bptjm-46	59	9	a	a	DET
bptjm-46	59	10	negative	negative	ADJ
bptjm-46	59	11	regulator	regulator	NOUN
bptjm-46	59	12	of	of	ADP
bptjm-46	59	13	cancer	cancer	NOUN
bptjm-46	59	14	as	as	ADP
bptjm-46	59	15	a	a	DET
bptjm-46	59	16	low	low	ADJ
bptjm-46	59	17	-	-	PUNCT
bptjm-46	59	18	penetrance	penetrance	NOUN
bptjm-46	59	19	tumor	tumor	NOUN
bptjm-46	59	20	suppressor	suppressor	NOUN
bptjm-46	59	21	gene19	gene19	NOUN
bptjm-46	59	22	.	.	PUNCT
bptjm-46	60	1	4	4	X
bptjm-46	60	2	.	.	X
bptjm-46	60	3	the	the	DET
bptjm-46	60	4	role	role	NOUN
bptjm-46	60	5	of	of	ADP
bptjm-46	60	6	glucose	glucose	NOUN
bptjm-46	60	7	transporter	transporter	NOUN
bptjm-46	60	8	(	(	PUNCT
bptjm-46	60	9	glut	glut	PROPN
bptjm-46	60	10	)	)	PUNCT
bptjm-46	60	11	and	and	CCONJ
bptjm-46	60	12	treatment	treatment	NOUN
bptjm-46	60	13	with	with	ADP
bptjm-46	60	14	fasentin	fasentin	NOUN
bptjm-46	60	15	and	and	CCONJ
bptjm-46	60	16	panitumumab	panitumumab	VERB
bptjm-46	60	17	the	the	DET
bptjm-46	60	18	two	two	NUM
bptjm-46	60	19	mentioned	mention	VERB
bptjm-46	60	20	changes	change	NOUN
bptjm-46	60	21	negatively	negatively	ADV
bptjm-46	60	22	impact	impact	VERB
bptjm-46	60	23	the	the	DET
bptjm-46	60	24	in	in	ADP
bptjm-46	60	25	vivo	vivo	ADJ
bptjm-46	60	26	microbiological	microbiological	ADJ
bptjm-46	60	27	environment	environment	NOUN
bptjm-46	60	28	for	for	ADP
bptjm-46	60	29	all	all	DET
bptjm-46	60	30	cancer	cancer	NOUN
bptjm-46	60	31	types	type	NOUN
bptjm-46	60	32	,	,	PUNCT
bptjm-46	60	33	because	because	SCONJ
bptjm-46	60	34	energy	energy	NOUN
bptjm-46	60	35	is	be	AUX
bptjm-46	60	36	a	a	DET
bptjm-46	60	37	common	common	ADJ
bptjm-46	60	38	restriction	restriction	NOUN
bptjm-46	60	39	for	for	ADP
bptjm-46	60	40	the	the	DET
bptjm-46	60	41	development	development	NOUN
bptjm-46	60	42	of	of	ADP
bptjm-46	60	43	all	all	DET
bptjm-46	60	44	tumors	tumor	NOUN
bptjm-46	60	45	.	.	PUNCT
bptjm-46	61	1	this	this	PRON
bptjm-46	61	2	has	have	AUX
bptjm-46	61	3	led	lead	VERB
bptjm-46	61	4	the	the	DET
bptjm-46	61	5	discussion	discussion	NOUN
bptjm-46	61	6	to	to	ADP
bptjm-46	61	7	the	the	DET
bptjm-46	61	8	molecular	molecular	ADJ
bptjm-46	61	9	metabolic	metabolic	NOUN
bptjm-46	61	10	pathway	pathway	NOUN
bptjm-46	61	11	of	of	ADP
bptjm-46	61	12	energy	energy	NOUN
bptjm-46	61	13	generation	generation	NOUN
bptjm-46	61	14	,	,	PUNCT
bptjm-46	61	15	especially	especially	ADV
bptjm-46	61	16	the	the	DET
bptjm-46	61	17	relationship	relationship	NOUN
bptjm-46	61	18	of	of	ADP
bptjm-46	61	19	blood	blood	NOUN
bptjm-46	61	20	glucose	glucose	NOUN
bptjm-46	61	21	and	and	CCONJ
bptjm-46	61	22	insulin	insulin	NOUN
bptjm-46	61	23	level	level	NOUN
bptjm-46	61	24	,	,	PUNCT
bptjm-46	61	25	as	as	ADV
bptjm-46	61	26	well	well	ADV
bptjm-46	61	27	as	as	ADP
bptjm-46	61	28	the	the	DET
bptjm-46	61	29	mechanism	mechanism	NOUN
bptjm-46	61	30	of	of	ADP
bptjm-46	61	31	how	how	SCONJ
bptjm-46	61	32	glucose	glucose	NOUN
bptjm-46	61	33	enters	enter	VERB
bptjm-46	61	34	into	into	ADP
bptjm-46	61	35	tissues	tissue	NOUN
bptjm-46	61	36	.	.	PUNCT
bptjm-46	62	1	in	in	ADP
bptjm-46	62	2	order	order	NOUN
bptjm-46	62	3	for	for	ADP
bptjm-46	62	4	the	the	DET
bptjm-46	62	5	intake	intake	NOUN
bptjm-46	62	6	of	of	ADP
bptjm-46	62	7	glucose	glucose	NOUN
bptjm-46	62	8	to	to	ADP
bptjm-46	62	9	peripheral	peripheral	ADJ
bptjm-46	62	10	tissues	tissue	NOUN
bptjm-46	62	11	from	from	ADP
bptjm-46	62	12	the	the	DET
bptjm-46	62	13	bloodstream	bloodstream	NOUN
bptjm-46	62	14	for	for	ADP
bptjm-46	62	15	further	further	ADJ
bptjm-46	62	16	mitochondrial	mitochondrial	ADJ
bptjm-46	62	17	oxidation	oxidation	NOUN
bptjm-46	62	18	and	and	CCONJ
bptjm-46	62	19	atp	atp	NOUN
bptjm-46	62	20	production	production	NOUN
bptjm-46	62	21	,	,	PUNCT
bptjm-46	62	22	mammalian	mammalian	ADJ
bptjm-46	62	23	cells	cell	NOUN
bptjm-46	62	24	have	have	AUX
bptjm-46	62	25	developed	develop	VERB
bptjm-46	62	26	a	a	DET
bptjm-46	62	27	family	family	NOUN
bptjm-46	62	28	of	of	ADP
bptjm-46	62	29	glucose	glucose	NOUN
bptjm-46	62	30	transporter	transporter	NOUN
bptjm-46	62	31	proteins	protein	NOUN
bptjm-46	62	32	for	for	ADP
bptjm-46	62	33	the	the	DET
bptjm-46	62	34	transportation	transportation	NOUN
bptjm-46	62	35	of	of	ADP
bptjm-46	62	36	sugar	sugar	NOUN
bptjm-46	62	37	through	through	ADP
bptjm-46	62	38	the	the	DET
bptjm-46	62	39	plasma	plasma	NOUN
bptjm-46	62	40	membrane20	membrane20	NOUN
bptjm-46	62	41	.	.	PUNCT
bptjm-46	63	1	the	the	DET
bptjm-46	63	2	abnormal	abnormal	ADJ
bptjm-46	63	3	blood	blood	NOUN
bptjm-46	63	4	glucose	glucose	NOUN
bptjm-46	63	5	level	level	NOUN
bptjm-46	63	6	within	within	ADP
bptjm-46	63	7	the	the	DET
bptjm-46	63	8	t2	t2	NOUN
bptjm-46	63	9	dm	dm	NOUN
bptjm-46	63	10	patients	patient	NOUN
bptjm-46	63	11	will	will	AUX
bptjm-46	63	12	induce	induce	VERB
bptjm-46	63	13	a	a	DET
bptjm-46	63	14	stronger	strong	ADJ
bptjm-46	63	15	expression	expression	NOUN
bptjm-46	63	16	of	of	ADP
bptjm-46	63	17	glut	glut	ADJ
bptjm-46	63	18	families	family	NOUN
bptjm-46	63	19	,	,	PUNCT
bptjm-46	63	20	especially	especially	ADV
bptjm-46	63	21	in	in	ADP
bptjm-46	63	22	the	the	DET
bptjm-46	63	23	energy	energy	NOUN
bptjm-46	63	24	-	-	PUNCT
bptjm-46	63	25	demanding	demand	VERB
bptjm-46	63	26	tissue	tissue	NOUN
bptjm-46	63	27	like	like	ADP
bptjm-46	63	28	adipose	adipose	PRON
bptjm-46	63	29	tissue	tissue	NOUN
bptjm-46	63	30	and	and	CCONJ
bptjm-46	63	31	breast	breast	NOUN
bptjm-46	63	32	cells	cell	NOUN
bptjm-46	63	33	,	,	PUNCT
bptjm-46	63	34	the	the	DET
bptjm-46	63	35	emphasis	emphasis	NOUN
bptjm-46	63	36	of	of	ADP
bptjm-46	63	37	our	our	PRON
bptjm-46	63	38	paper	paper	NOUN
bptjm-46	63	39	.	.	PUNCT
bptjm-46	64	1	there	there	PRON
bptjm-46	64	2	are	be	VERB
bptjm-46	64	3	3	3	NUM
bptjm-46	64	4	classes	class	NOUN
bptjm-46	64	5	of	of	ADP
bptjm-46	64	6	glut	glut	NOUN
bptjm-46	64	7	,	,	PUNCT
bptjm-46	64	8	and	and	CCONJ
bptjm-46	64	9	the	the	DET
bptjm-46	64	10	responsible	responsible	ADJ
bptjm-46	64	11	group	group	NOUN
bptjm-46	64	12	here	here	ADV
bptjm-46	64	13	is	be	AUX
bptjm-46	64	14	class	class	NOUN
bptjm-46	64	15	i	i	PRON
bptjm-46	64	16	glut	glut	VERB
bptjm-46	64	17	,	,	PUNCT
bptjm-46	64	18	which	which	PRON
bptjm-46	64	19	contains	contain	VERB
bptjm-46	64	20	glut1	glut1	PROPN
bptjm-46	64	21	-	-	PUNCT
bptjm-46	64	22	4	4	NUM
bptjm-46	64	23	and	and	CCONJ
bptjm-46	64	24	glut1421	glut1421	PROPN
bptjm-46	64	25	.	.	PROPN
bptjm-46	65	1	di	di	PROPN
bptjm-46	65	2	�	�	PROPN
bptjm-46	65	3	erent	erent	NOUN
bptjm-46	65	4	glut	glut	NOUN
bptjm-46	65	5	types	type	NOUN
bptjm-46	65	6	are	be	AUX
bptjm-46	65	7	responsible	responsible	ADJ
bptjm-46	65	8	for	for	ADP
bptjm-46	65	9	the	the	DET
bptjm-46	65	10	intake	intake	NOUN
bptjm-46	65	11	by	by	ADP
bptjm-46	65	12	di	di	NOUN
bptjm-46	65	13	�	�	PROPN
bptjm-46	65	14	erent	erent	NOUN
bptjm-46	65	15	tissues	tissue	NOUN
bptjm-46	65	16	,	,	PUNCT
bptjm-46	65	17	and	and	CCONJ
bptjm-46	65	18	our	our	PRON
bptjm-46	65	19	emphasis	emphasis	NOUN
bptjm-46	65	20	will	will	AUX
bptjm-46	65	21	be	be	AUX
bptjm-46	65	22	on	on	ADP
bptjm-46	65	23	glut4	glut4	PROPN
bptjm-46	65	24	,	,	PUNCT
bptjm-46	65	25	the	the	DET
bptjm-46	65	26	one	one	NOUN
bptjm-46	65	27	that	that	PRON
bptjm-46	65	28	controls	control	VERB
bptjm-46	65	29	uptake	uptake	NOUN
bptjm-46	65	30	of	of	ADP
bptjm-46	65	31	glucose	glucose	NOUN
bptjm-46	65	32	by	by	ADP
bptjm-46	65	33	skeletal	skeletal	ADJ
bptjm-46	65	34	muscle	muscle	NOUN
bptjm-46	65	35	,	,	PUNCT
bptjm-46	65	36	cardiac	cardiac	ADJ
bptjm-46	65	37	muscle	muscle	NOUN
bptjm-46	65	38	,	,	PUNCT
bptjm-46	65	39	and	and	CCONJ
bptjm-46	65	40	most	most	ADV
bptjm-46	65	41	importantly	importantly	ADV
bptjm-46	65	42	for	for	ADP
bptjm-46	65	43	cancer	cancer	NOUN
bptjm-46	65	44	development	development	NOUN
bptjm-46	65	45	,	,	PUNCT
bptjm-46	65	46	adipose	adipose	ADJ
bptjm-46	65	47	tissue22	tissue22	NOUN
bptjm-46	65	48	.	.	PUNCT
bptjm-46	66	1	the	the	DET
bptjm-46	66	2	expression	expression	NOUN
bptjm-46	66	3	of	of	ADP
bptjm-46	66	4	glut4	glut4	NOUN
bptjm-46	66	5	is	be	AUX
bptjm-46	66	6	heavily	heavily	ADV
bptjm-46	66	7	regulated	regulate	VERB
bptjm-46	66	8	by	by	ADP
bptjm-46	66	9	the	the	DET
bptjm-46	66	10	level	level	NOUN
bptjm-46	66	11	of	of	ADP
bptjm-46	66	12	presenting	present	VERB
bptjm-46	66	13	insulin	insulin	NOUN
bptjm-46	66	14	.	.	PUNCT
bptjm-46	67	1	stored	store	VERB
bptjm-46	67	2	in	in	ADP
bptjm-46	67	3	intracellular	intracellular	ADJ
bptjm-46	67	4	vesicles	vesicle	NOUN
bptjm-46	67	5	,	,	PUNCT
bptjm-46	67	6	glut4	glut4	PROPN
bptjm-46	67	7	is	be	AUX
bptjm-46	67	8	released	release	VERB
bptjm-46	67	9	vesicular	vesicular	ADJ
bptjm-46	67	10	fusion	fusion	NOUN
bptjm-46	67	11	once	once	SCONJ
bptjm-46	67	12	insulin	insulin	NOUN
bptjm-46	67	13	binds	bind	VERB
bptjm-46	67	14	with	with	ADP
bptjm-46	67	15	the	the	DET
bptjm-46	67	16	insulin	insulin	NOUN
bptjm-46	67	17	receptors	receptor	NOUN
bptjm-46	67	18	expressed	express	VERB
bptjm-46	67	19	on	on	ADP
bptjm-46	67	20	the	the	DET
bptjm-46	67	21	plasma	plasma	NOUN
bptjm-46	67	22	membrane23	membrane23	NOUN
bptjm-46	67	23	.	.	PUNCT
bptjm-46	68	1	increased	increase	VERB
bptjm-46	68	2	glut4	glut4	NOUN
bptjm-46	68	3	availability	availability	NOUN
bptjm-46	68	4	to	to	ADP
bptjm-46	68	5	glucose	glucose	NOUN
bptjm-46	68	6	in	in	ADP
bptjm-46	68	7	the	the	DET
bptjm-46	68	8	bloodstream	bloodstream	NOUN
bptjm-46	68	9	causes	cause	VERB
bptjm-46	68	10	more	more	ADJ
bptjm-46	68	11	glucose	glucose	NOUN
bptjm-46	68	12	uptake	uptake	NOUN
bptjm-46	68	13	by	by	ADP
bptjm-46	68	14	fat	fat	ADJ
bptjm-46	68	15	.	.	PUNCT
bptjm-46	69	1	this	this	PRON
bptjm-46	69	2	is	be	AUX
bptjm-46	69	3	thought	think	VERB
bptjm-46	69	4	to	to	PART
bptjm-46	69	5	be	be	AUX
bptjm-46	69	6	the	the	DET
bptjm-46	69	7	e	e	NOUN
bptjm-46	69	8	�	�	NOUN
bptjm-46	69	9	ort	ort	NOUN
bptjm-46	69	10	against	against	ADP
bptjm-46	69	11	the	the	DET
bptjm-46	69	12	development	development	NOUN
bptjm-46	69	13	of	of	ADP
bptjm-46	69	14	insulin	insulin	NOUN
bptjm-46	69	15	resistance	resistance	NOUN
bptjm-46	69	16	,	,	PUNCT
bptjm-46	69	17	although	although	SCONJ
bptjm-46	69	18	it	it	PRON
bptjm-46	69	19	also	also	ADV
bptjm-46	69	20	promotes	promote	VERB
bptjm-46	69	21	the	the	DET
bptjm-46	69	22	creation	creation	NOUN
bptjm-46	69	23	of	of	ADP
bptjm-46	69	24	a	a	DET
bptjm-46	69	25	positive	positive	ADJ
bptjm-46	69	26	feedback	feedback	NOUN
bptjm-46	69	27	loop	loop	NOUN
bptjm-46	69	28	for	for	ADP
bptjm-46	69	29	fat	fat	ADJ
bptjm-46	69	30	accumulation	accumulation	NOUN
bptjm-46	69	31	and	and	CCONJ
bptjm-46	69	32	development	development	NOUN
bptjm-46	69	33	of	of	ADP
bptjm-46	69	34	diabetes22	diabetes22	NOUN
bptjm-46	69	35	.	.	PUNCT
bptjm-46	70	1	this	this	PRON
bptjm-46	70	2	has	have	AUX
bptjm-46	70	3	led	lead	VERB
bptjm-46	70	4	berkeley	berkeley	PROPN
bptjm-46	70	5	pharma	pharma	PROPN
bptjm-46	70	6	tech	tech	NOUN
bptjm-46	70	7	journal	journal	NOUN
bptjm-46	70	8	of	of	ADP
bptjm-46	70	9	medicine	medicine	NOUN
bptjm-46	70	10	|	|	ADV
bptjm-46	70	11	106	106	NUM
bptjm-46	70	12	the	the	DET
bptjm-46	70	13	research	research	NOUN
bptjm-46	70	14	interest	interest	NOUN
bptjm-46	70	15	to	to	ADP
bptjm-46	70	16	a	a	DET
bptjm-46	70	17	potential	potential	ADJ
bptjm-46	70	18	drug	drug	NOUN
bptjm-46	70	19	that	that	PRON
bptjm-46	70	20	restricts	restrict	VERB
bptjm-46	70	21	metabolic	metabolic	NOUN
bptjm-46	70	22	e	e	NOUN
bptjm-46	70	23	�	�	NOUN
bptjm-46	70	24	ciency	ciency	NOUN
bptjm-46	70	25	of	of	ADP
bptjm-46	70	26	cancer	cancer	NOUN
bptjm-46	70	27	cells	cell	NOUN
bptjm-46	70	28	by	by	ADP
bptjm-46	70	29	inhibiting	inhibit	VERB
bptjm-46	70	30	the	the	DET
bptjm-46	70	31	process	process	NOUN
bptjm-46	70	32	of	of	ADP
bptjm-46	70	33	glucose	glucose	NOUN
bptjm-46	70	34	intake	intake	NOUN
bptjm-46	70	35	.	.	PUNCT
bptjm-46	71	1	there	there	PRON
bptjm-46	71	2	are	be	VERB
bptjm-46	71	3	two	two	NUM
bptjm-46	71	4	potential	potential	ADJ
bptjm-46	71	5	targets	target	NOUN
bptjm-46	71	6	in	in	ADP
bptjm-46	71	7	regard	regard	NOUN
bptjm-46	71	8	to	to	ADP
bptjm-46	71	9	this	this	DET
bptjm-46	71	10	possible	possible	ADJ
bptjm-46	71	11	map	map	NOUN
bptjm-46	71	12	.	.	PUNCT
bptjm-46	72	1	first	first	ADV
bptjm-46	72	2	,	,	PUNCT
bptjm-46	72	3	the	the	DET
bptjm-46	72	4	insulin	insulin	NOUN
bptjm-46	72	5	receptors	receptor	NOUN
bptjm-46	72	6	are	be	AUX
bptjm-46	72	7	receptor	receptor	NOUN
bptjm-46	72	8	tyrosine	tyrosine	PROPN
bptjm-46	72	9	kinase	kinase	PROPN
bptjm-46	72	10	(	(	PUNCT
bptjm-46	72	11	rtk	rtk	PROPN
bptjm-46	72	12	)	)	PUNCT
bptjm-46	72	13	,	,	PUNCT
bptjm-46	72	14	which	which	PRON
bptjm-46	72	15	requires	require	VERB
bptjm-46	72	16	the	the	DET
bptjm-46	72	17	process	process	NOUN
bptjm-46	72	18	of	of	ADP
bptjm-46	72	19	dimerization	dimerization	NOUN
bptjm-46	72	20	and	and	CCONJ
bptjm-46	72	21	phosphorylation	phosphorylation	NOUN
bptjm-46	72	22	to	to	ADP
bptjm-46	72	23	the	the	DET
bptjm-46	72	24	transduction	transduction	NOUN
bptjm-46	72	25	of	of	ADP
bptjm-46	72	26	the	the	DET
bptjm-46	72	27	chemical	chemical	ADJ
bptjm-46	72	28	substances	substance	NOUN
bptjm-46	72	29	from	from	ADP
bptjm-46	72	30	ligands	ligand	NOUN
bptjm-46	72	31	to	to	ADP
bptjm-46	72	32	intracellular	intracellular	ADJ
bptjm-46	72	33	electric	electric	ADJ
bptjm-46	72	34	signals24	signals24	NOUN
bptjm-46	72	35	.	.	PUNCT
bptjm-46	73	1	this	this	PRON
bptjm-46	73	2	is	be	AUX
bptjm-46	73	3	not	not	PART
bptjm-46	73	4	unique	unique	ADJ
bptjm-46	73	5	because	because	SCONJ
bptjm-46	73	6	many	many	ADJ
bptjm-46	73	7	signal	signal	NOUN
bptjm-46	73	8	regulation	regulation	NOUN
bptjm-46	73	9	pathways	pathway	NOUN
bptjm-46	73	10	utilize	utilize	VERB
bptjm-46	73	11	rtk	rtk	PROPN
bptjm-46	73	12	as	as	ADV
bptjm-46	73	13	well	well	ADV
bptjm-46	73	14	,	,	PUNCT
bptjm-46	73	15	and	and	CCONJ
bptjm-46	73	16	they	they	PRON
bptjm-46	73	17	can	can	AUX
bptjm-46	73	18	also	also	ADV
bptjm-46	73	19	be	be	AUX
bptjm-46	73	20	seen	see	VERB
bptjm-46	73	21	as	as	ADP
bptjm-46	73	22	targets	target	NOUN
bptjm-46	73	23	.	.	PUNCT
bptjm-46	74	1	therefore	therefore	ADV
bptjm-46	74	2	,	,	PUNCT
bptjm-46	74	3	a	a	DET
bptjm-46	74	4	potential	potential	ADJ
bptjm-46	74	5	therapy	therapy	NOUN
bptjm-46	74	6	is	be	AUX
bptjm-46	74	7	to	to	PART
bptjm-46	74	8	block	block	VERB
bptjm-46	74	9	or	or	CCONJ
bptjm-46	74	10	terminate	terminate	VERB
bptjm-46	74	11	the	the	DET
bptjm-46	74	12	phosphorylation	phosphorylation	NOUN
bptjm-46	74	13	process	process	NOUN
bptjm-46	74	14	of	of	ADP
bptjm-46	74	15	rtks	rtks	NOUN
bptjm-46	74	16	with	with	ADP
bptjm-46	74	17	pharmaceutical	pharmaceutical	ADJ
bptjm-46	74	18	interventions	intervention	NOUN
bptjm-46	74	19	.	.	PUNCT
bptjm-46	75	1	there	there	PRON
bptjm-46	75	2	are	be	VERB
bptjm-46	75	3	already	already	ADV
bptjm-46	75	4	drugs	drug	NOUN
bptjm-46	75	5	developed	develop	VERB
bptjm-46	75	6	for	for	ADP
bptjm-46	75	7	cancer	cancer	NOUN
bptjm-46	75	8	treatments	treatment	NOUN
bptjm-46	75	9	via	via	ADP
bptjm-46	75	10	this	this	DET
bptjm-46	75	11	pathway	pathway	NOUN
bptjm-46	75	12	,	,	PUNCT
bptjm-46	75	13	namely	namely	ADV
bptjm-46	75	14	the	the	DET
bptjm-46	75	15	panitumumab25	panitumumab25	NOUN
bptjm-46	75	16	.	.	PUNCT
bptjm-46	76	1	panitumumab	panitumumab	NOUN
bptjm-46	76	2	is	be	AUX
bptjm-46	76	3	an	an	DET
bptjm-46	76	4	agent	agent	NOUN
bptjm-46	76	5	serving	serve	VERB
bptjm-46	76	6	to	to	PART
bptjm-46	76	7	restrict	restrict	VERB
bptjm-46	76	8	progression	progression	NOUN
bptjm-46	76	9	of	of	ADP
bptjm-46	76	10	colorectal	colorectal	ADJ
bptjm-46	76	11	cancer	cancer	NOUN
bptjm-46	76	12	on	on	ADP
bptjm-46	76	13	epithelial	epithelial	ADJ
bptjm-46	76	14	level26	level26	NOUN
bptjm-46	76	15	.	.	PUNCT
bptjm-46	77	1	epithelial	epithelial	ADJ
bptjm-46	77	2	cancer	cancer	NOUN
bptjm-46	77	3	is	be	AUX
bptjm-46	77	4	a	a	DET
bptjm-46	77	5	critical	critical	ADJ
bptjm-46	77	6	cancer	cancer	NOUN
bptjm-46	77	7	type	type	NOUN
bptjm-46	77	8	that	that	PRON
bptjm-46	77	9	is	be	AUX
bptjm-46	77	10	a	a	DET
bptjm-46	77	11	�	�	NOUN
bptjm-46	77	12	ected	ecte	VERB
bptjm-46	77	13	by	by	ADP
bptjm-46	77	14	t2	t2	PROPN
bptjm-46	77	15	dm	dm	PROPN
bptjm-46	77	16	,	,	PUNCT
bptjm-46	77	17	for	for	ADP
bptjm-46	77	18	the	the	DET
bptjm-46	77	19	transformation	transformation	NOUN
bptjm-46	77	20	of	of	ADP
bptjm-46	77	21	normal	normal	ADJ
bptjm-46	77	22	epithelial	epithelial	NOUN
bptjm-46	77	23	to	to	ADP
bptjm-46	77	24	cancerous	cancerous	ADJ
bptjm-46	77	25	cells	cell	NOUN
bptjm-46	77	26	requires	require	VERB
bptjm-46	77	27	enormous	enormous	ADJ
bptjm-46	77	28	amounts	amount	NOUN
bptjm-46	77	29	of	of	ADP
bptjm-46	77	30	energy	energy	NOUN
bptjm-46	77	31	consumption	consumption	NOUN
bptjm-46	77	32	.	.	PUNCT
bptjm-46	78	1	panitumumab	panitumumab	NOUN
bptjm-46	78	2	inhibits	inhibit	VERB
bptjm-46	78	3	the	the	DET
bptjm-46	78	4	function	function	NOUN
bptjm-46	78	5	of	of	ADP
bptjm-46	78	6	epithelial	epithelial	ADJ
bptjm-46	78	7	-	-	PUNCT
bptjm-46	78	8	growth	growth	NOUN
bptjm-46	78	9	factor	factor	NOUN
bptjm-46	78	10	receptor	receptor	NOUN
bptjm-46	78	11	(	(	PUNCT
bptjm-46	78	12	egfr	egfr	NOUN
bptjm-46	78	13	)	)	PUNCT
bptjm-46	78	14	,	,	PUNCT
bptjm-46	78	15	which	which	PRON
bptjm-46	78	16	after	after	ADP
bptjm-46	78	17	cancerous	cancerous	ADJ
bptjm-46	78	18	lesion	lesion	NOUN
bptjm-46	78	19	,	,	PUNCT
bptjm-46	78	20	starts	start	VERB
bptjm-46	78	21	the	the	DET
bptjm-46	78	22	process	process	NOUN
bptjm-46	78	23	of	of	ADP
bptjm-46	78	24	uncontrolled	uncontrolled	ADJ
bptjm-46	78	25	replication27	replication27	NOUN
bptjm-46	78	26	.	.	PUNCT
bptjm-46	79	1	panitumumab	panitumumab	NOUN
bptjm-46	79	2	,	,	PUNCT
bptjm-46	79	3	by	by	ADP
bptjm-46	79	4	binding	bind	VERB
bptjm-46	79	5	to	to	ADP
bptjm-46	79	6	the	the	DET
bptjm-46	79	7	extracellular	extracellular	ADJ
bptjm-46	79	8	receptor	receptor	NOUN
bptjm-46	79	9	of	of	ADP
bptjm-46	79	10	egfr	egfr	NOUN
bptjm-46	79	11	and	and	CCONJ
bptjm-46	79	12	outcompeting	outcompete	VERB
bptjm-46	79	13	the	the	DET
bptjm-46	79	14	essential	essential	ADJ
bptjm-46	79	15	nutrients	nutrient	NOUN
bptjm-46	79	16	for	for	ADP
bptjm-46	79	17	cell	cell	NOUN
bptjm-46	79	18	proliferation	proliferation	NOUN
bptjm-46	79	19	,	,	PUNCT
bptjm-46	79	20	e	e	NOUN
bptjm-46	79	21	�	�	NOUN
bptjm-46	79	22	ectively	ectively	ADV
bptjm-46	79	23	inhibits	inhibit	VERB
bptjm-46	79	24	the	the	DET
bptjm-46	79	25	progression	progression	NOUN
bptjm-46	79	26	.	.	PUNCT
bptjm-46	80	1	recently	recently	ADV
bptjm-46	80	2	,	,	PUNCT
bptjm-46	80	3	clinical	clinical	ADJ
bptjm-46	80	4	trials	trial	NOUN
bptjm-46	80	5	were	be	AUX
bptjm-46	80	6	made	make	VERB
bptjm-46	80	7	with	with	ADP
bptjm-46	80	8	panitumumab	panitumumab	NOUN
bptjm-46	80	9	on	on	ADP
bptjm-46	80	10	its	its	PRON
bptjm-46	80	11	pharmaceutical	pharmaceutical	ADJ
bptjm-46	80	12	e	e	NOUN
bptjm-46	80	13	�	�	NOUN
bptjm-46	80	14	ect	ect	VERB
bptjm-46	80	15	on	on	ADP
bptjm-46	80	16	cancer	cancer	NOUN
bptjm-46	80	17	types	type	NOUN
bptjm-46	80	18	other	other	ADJ
bptjm-46	80	19	than	than	ADP
bptjm-46	80	20	colorectal	colorectal	ADJ
bptjm-46	80	21	cancer	cancer	NOUN
bptjm-46	80	22	.	.	PUNCT
bptjm-46	81	1	records	record	NOUN
bptjm-46	81	2	show	show	VERB
bptjm-46	81	3	that	that	SCONJ
bptjm-46	81	4	it	it	PRON
bptjm-46	81	5	can	can	AUX
bptjm-46	81	6	also	also	ADV
bptjm-46	81	7	repress	repress	VERB
bptjm-46	81	8	the	the	DET
bptjm-46	81	9	development	development	NOUN
bptjm-46	81	10	of	of	ADP
bptjm-46	81	11	head	head	NOUN
bptjm-46	81	12	cancer	cancer	NOUN
bptjm-46	81	13	and	and	CCONJ
bptjm-46	81	14	neck	neck	NOUN
bptjm-46	81	15	cancer28	cancer28	NOUN
bptjm-46	81	16	.	.	PUNCT
bptjm-46	82	1	secondly	secondly	ADV
bptjm-46	82	2	,	,	PUNCT
bptjm-46	82	3	the	the	DET
bptjm-46	82	4	drug	drug	NOUN
bptjm-46	82	5	can	can	AUX
bptjm-46	82	6	also	also	ADV
bptjm-46	82	7	target	target	VERB
bptjm-46	82	8	the	the	DET
bptjm-46	82	9	intake	intake	NOUN
bptjm-46	82	10	of	of	ADP
bptjm-46	82	11	glucose	glucose	NOUN
bptjm-46	82	12	by	by	ADP
bptjm-46	82	13	the	the	DET
bptjm-46	82	14	direct	direct	ADJ
bptjm-46	82	15	blockage	blockage	NOUN
bptjm-46	82	16	of	of	ADP
bptjm-46	82	17	glut4	glut4	PROPN
bptjm-46	82	18	.	.	PUNCT
bptjm-46	83	1	fasentin	fasentin	PROPN
bptjm-46	83	2	serves	serve	VERB
bptjm-46	83	3	2	2	NUM
bptjm-46	83	4	functions	function	NOUN
bptjm-46	83	5	for	for	ADP
bptjm-46	83	6	the	the	DET
bptjm-46	83	7	suppression	suppression	NOUN
bptjm-46	83	8	of	of	ADP
bptjm-46	83	9	tumor	tumor	NOUN
bptjm-46	83	10	establishment	establishment	NOUN
bptjm-46	83	11	.	.	PUNCT
bptjm-46	84	1	firstly	firstly	ADV
bptjm-46	84	2	,	,	PUNCT
bptjm-46	84	3	fasentin	fasentin	PROPN
bptjm-46	84	4	is	be	AUX
bptjm-46	84	5	a	a	DET
bptjm-46	84	6	direct	direct	ADJ
bptjm-46	84	7	inhibitor	inhibitor	NOUN
bptjm-46	84	8	of	of	ADP
bptjm-46	84	9	glut4	glut4	PROPN
bptjm-46	84	10	.	.	PUNCT
bptjm-46	85	1	by	by	ADP
bptjm-46	85	2	outcompeting	outcompete	VERB
bptjm-46	85	3	the	the	DET
bptjm-46	85	4	glucose	glucose	NOUN
bptjm-46	85	5	on	on	ADP
bptjm-46	85	6	binding	bind	VERB
bptjm-46	85	7	a	a	DET
bptjm-46	85	8	�	�	NOUN
bptjm-46	85	9	nity	nity	NOUN
bptjm-46	85	10	represented	represent	VERB
bptjm-46	85	11	by	by	ADP
bptjm-46	85	12	a	a	DET
bptjm-46	85	13	higher	high	ADJ
bptjm-46	85	14	ic50	ic50	PROPN
bptjm-46	85	15	value29	value29	NOUN
bptjm-46	85	16	,	,	PUNCT
bptjm-46	85	17	fasentin	fasentin	PROPN
bptjm-46	85	18	e	e	NOUN
bptjm-46	85	19	�	�	PROPN
bptjm-46	85	20	ectively	ectively	ADV
bptjm-46	85	21	reduces	reduce	VERB
bptjm-46	85	22	the	the	DET
bptjm-46	85	23	glucose	glucose	NOUN
bptjm-46	85	24	uptake	uptake	ADJ
bptjm-46	85	25	by	by	ADP
bptjm-46	85	26	cancer	cancer	NOUN
bptjm-46	85	27	-	-	PUNCT
bptjm-46	85	28	surrounding	surround	VERB
bptjm-46	85	29	tissue	tissue	NOUN
bptjm-46	85	30	and	and	CCONJ
bptjm-46	85	31	therefore	therefore	ADV
bptjm-46	85	32	,	,	PUNCT
bptjm-46	85	33	an	an	DET
bptjm-46	85	34	inhibitory	inhibitory	ADJ
bptjm-46	85	35	e	e	NOUN
bptjm-46	85	36	�	�	NOUN
bptjm-46	85	37	ort	ort	NOUN
bptjm-46	85	38	is	be	AUX
bptjm-46	85	39	made	make	VERB
bptjm-46	85	40	to	to	PART
bptjm-46	85	41	reduce	reduce	VERB
bptjm-46	85	42	energy	energy	NOUN
bptjm-46	85	43	production	production	NOUN
bptjm-46	85	44	.	.	PUNCT
bptjm-46	86	1	secondly	secondly	ADV
bptjm-46	86	2	,	,	PUNCT
bptjm-46	86	3	fasentin	fasentin	PROPN
bptjm-46	86	4	presence	presence	NOUN
bptjm-46	86	5	serves	serve	VERB
bptjm-46	86	6	as	as	ADP
bptjm-46	86	7	a	a	DET
bptjm-46	86	8	stimulatory	stimulatory	ADJ
bptjm-46	86	9	signal	signal	NOUN
bptjm-46	86	10	for	for	ADP
bptjm-46	86	11	the	the	DET
bptjm-46	86	12	activation	activation	NOUN
bptjm-46	86	13	of	of	ADP
bptjm-46	86	14	fas	fas	ADJ
bptjm-46	86	15	-	-	PUNCT
bptjm-46	86	16	directed	direct	VERB
bptjm-46	86	17	apoptosis	apoptosis	NOUN
bptjm-46	86	18	process	process	NOUN
bptjm-46	86	19	of	of	ADP
bptjm-46	86	20	cancer30	cancer30	NOUN
bptjm-46	86	21	.	.	PUNCT
bptjm-46	87	1	therefore	therefore	ADV
bptjm-46	87	2	,	,	PUNCT
bptjm-46	87	3	intake	intake	NOUN
bptjm-46	87	4	of	of	ADP
bptjm-46	87	5	fasentin	fasentin	NOUN
bptjm-46	87	6	can	can	AUX
bptjm-46	87	7	both	both	PRON
bptjm-46	87	8	directly	directly	ADV
bptjm-46	87	9	,	,	PUNCT
bptjm-46	87	10	by	by	ADP
bptjm-46	87	11	inducing	induce	VERB
bptjm-46	87	12	cancer	cancer	NOUN
bptjm-46	87	13	cell	cell	NOUN
bptjm-46	87	14	death	death	NOUN
bptjm-46	87	15	by	by	ADP
bptjm-46	87	16	apoptosis	apoptosis	NOUN
bptjm-46	87	17	and	and	CCONJ
bptjm-46	87	18	indirectly	indirectly	ADV
bptjm-46	87	19	,	,	PUNCT
bptjm-46	87	20	by	by	ADP
bptjm-46	87	21	restricting	restrict	VERB
bptjm-46	87	22	the	the	DET
bptjm-46	87	23	amount	amount	NOUN
bptjm-46	87	24	of	of	ADP
bptjm-46	87	25	glucose	glucose	NOUN
bptjm-46	87	26	in	in	ADP
bptjm-46	87	27	�	�	PROPN
bptjm-46	87	28	ow	ow	PROPN
bptjm-46	87	29	.	.	PROPN
bptjm-46	87	30	berkeley	berkeley	PROPN
bptjm-46	87	31	pharma	pharma	PROPN
bptjm-46	87	32	tech	tech	PROPN
bptjm-46	87	33	journal	journal	NOUN
bptjm-46	87	34	of	of	ADP
bptjm-46	87	35	medicine	medicine	NOUN
bptjm-46	87	36	|	|	ADV
bptjm-46	87	37	107	107	NUM
bptjm-46	87	38	5	5	NUM
bptjm-46	87	39	.	.	PUNCT
bptjm-46	87	40	treatment	treatment	NOUN
bptjm-46	87	41	incorporating	incorporate	VERB
bptjm-46	87	42	monocarboxylate	monocarboxylate	ADJ
bptjm-46	87	43	transporter	transporter	NOUN
bptjm-46	87	44	4	4	NUM
bptjm-46	87	45	and	and	CCONJ
bptjm-46	87	46	cannabinoid	cannabinoid	VERB
bptjm-46	87	47	receptor	receptor	NOUN
bptjm-46	87	48	2	2	NUM
bptjm-46	87	49	the	the	DET
bptjm-46	87	50	distorted	distorted	ADJ
bptjm-46	87	51	glucose	glucose	NOUN
bptjm-46	87	52	in	in	ADP
bptjm-46	87	53	cancer	cancer	NOUN
bptjm-46	87	54	cells	cell	NOUN
bptjm-46	87	55	results	result	VERB
bptjm-46	87	56	in	in	ADP
bptjm-46	87	57	the	the	DET
bptjm-46	87	58	upregulation	upregulation	NOUN
bptjm-46	87	59	of	of	ADP
bptjm-46	87	60	glycolysis	glycolysis	NOUN
bptjm-46	87	61	in	in	ADP
bptjm-46	87	62	cancer	cancer	NOUN
bptjm-46	87	63	cells	cell	NOUN
bptjm-46	87	64	.	.	PUNCT
bptjm-46	88	1	this	this	PRON
bptjm-46	88	2	induces	induce	VERB
bptjm-46	88	3	a	a	DET
bptjm-46	88	4	high	high	ADJ
bptjm-46	88	5	amount	amount	NOUN
bptjm-46	88	6	of	of	ADP
bptjm-46	88	7	lactate	lactate	NOUN
bptjm-46	88	8	production	production	NOUN
bptjm-46	88	9	,	,	PUNCT
bptjm-46	88	10	and	and	CCONJ
bptjm-46	88	11	consequently	consequently	ADV
bptjm-46	88	12	,	,	PUNCT
bptjm-46	88	13	its	its	PRON
bptjm-46	88	14	accumulation	accumulation	NOUN
bptjm-46	88	15	in	in	ADP
bptjm-46	88	16	these	these	DET
bptjm-46	88	17	cells	cell	NOUN
bptjm-46	88	18	.	.	PUNCT
bptjm-46	89	1	blocking	block	VERB
bptjm-46	89	2	upregulation	upregulation	NOUN
bptjm-46	89	3	of	of	ADP
bptjm-46	89	4	aerobic	aerobic	ADJ
bptjm-46	89	5	glycolysis	glycolysis	NOUN
bptjm-46	89	6	has	have	AUX
bptjm-46	89	7	been	be	AUX
bptjm-46	89	8	ine	ine	PROPN
bptjm-46	89	9	�	�	PROPN
bptjm-46	89	10	ective	ective	ADJ
bptjm-46	89	11	,	,	PUNCT
bptjm-46	89	12	such	such	ADJ
bptjm-46	89	13	as	as	ADP
bptjm-46	89	14	using	use	VERB
bptjm-46	89	15	2	2	NUM
bptjm-46	89	16	-	-	PUNCT
bptjm-46	89	17	dg	dg	NOUN
bptjm-46	89	18	as	as	ADP
bptjm-46	89	19	an	an	DET
bptjm-46	89	20	anti	anti	ADJ
bptjm-46	89	21	-	-	ADJ
bptjm-46	89	22	cancer	cancer	ADJ
bptjm-46	89	23	agent	agent	NOUN
bptjm-46	89	24	.	.	PUNCT
bptjm-46	90	1	mere	mere	ADJ
bptjm-46	90	2	inhibition	inhibition	NOUN
bptjm-46	90	3	of	of	ADP
bptjm-46	90	4	glycolysis	glycolysis	NOUN
bptjm-46	90	5	is	be	AUX
bptjm-46	90	6	insu	insu	PROPN
bptjm-46	90	7	�	�	PROPN
bptjm-46	90	8	cient	cient	NOUN
bptjm-46	90	9	for	for	ADP
bptjm-46	90	10	the	the	DET
bptjm-46	90	11	eradication	eradication	NOUN
bptjm-46	90	12	of	of	ADP
bptjm-46	90	13	cancer	cancer	NOUN
bptjm-46	90	14	cells	cell	NOUN
bptjm-46	90	15	due	due	ADP
bptjm-46	90	16	to	to	ADP
bptjm-46	90	17	the	the	DET
bptjm-46	90	18	reason	reason	NOUN
bptjm-46	90	19	that	that	SCONJ
bptjm-46	90	20	cancer	cancer	NOUN
bptjm-46	90	21	cells	cell	NOUN
bptjm-46	90	22	have	have	VERB
bptjm-46	90	23	the	the	DET
bptjm-46	90	24	potential	potential	NOUN
bptjm-46	90	25	to	to	PART
bptjm-46	90	26	adapt	adapt	VERB
bptjm-46	90	27	their	their	PRON
bptjm-46	90	28	metabolism	metabolism	NOUN
bptjm-46	90	29	to	to	ADP
bptjm-46	90	30	their	their	PRON
bptjm-46	90	31	environmental	environmental	ADJ
bptjm-46	90	32	conditions	condition	NOUN
bptjm-46	90	33	.	.	PUNCT
bptjm-46	91	1	upon	upon	SCONJ
bptjm-46	91	2	glycolytic	glycolytic	ADJ
bptjm-46	91	3	suppression	suppression	NOUN
bptjm-46	91	4	in	in	ADP
bptjm-46	91	5	multiple	multiple	ADJ
bptjm-46	91	6	types	type	NOUN
bptjm-46	91	7	of	of	ADP
bptjm-46	91	8	tumor	tumor	NOUN
bptjm-46	91	9	cells	cell	NOUN
bptjm-46	91	10	,	,	PUNCT
bptjm-46	91	11	intracellular	intracellular	ADJ
bptjm-46	91	12	energy	energy	NOUN
bptjm-46	91	13	metabolism	metabolism	NOUN
bptjm-46	91	14	is	be	AUX
bptjm-46	91	15	reprogrammed	reprogramme	VERB
bptjm-46	91	16	in	in	ADP
bptjm-46	91	17	an	an	DET
bptjm-46	91	18	autophagy	autophagy	ADJ
bptjm-46	91	19	-	-	PUNCT
bptjm-46	91	20	dependent	dependent	ADJ
bptjm-46	91	21	manner	manner	NOUN
bptjm-46	91	22	to	to	PART
bptjm-46	91	23	ensure	ensure	VERB
bptjm-46	91	24	cellular	cellular	ADJ
bptjm-46	91	25	survival	survival	NOUN
bptjm-46	91	26	.	.	PUNCT
bptjm-46	92	1	rather	rather	ADV
bptjm-46	92	2	,	,	PUNCT
bptjm-46	92	3	a	a	DET
bptjm-46	92	4	possible	possible	ADJ
bptjm-46	92	5	treatment	treatment	NOUN
bptjm-46	92	6	method	method	NOUN
bptjm-46	92	7	for	for	ADP
bptjm-46	92	8	these	these	DET
bptjm-46	92	9	cancer	cancer	NOUN
bptjm-46	92	10	cells	cell	NOUN
bptjm-46	92	11	is	be	AUX
bptjm-46	92	12	aggravation	aggravation	ADJ
bptjm-46	92	13	into	into	ADP
bptjm-46	92	14	a	a	DET
bptjm-46	92	15	hyper	hyper	ADJ
bptjm-46	92	16	-	-	ADJ
bptjm-46	92	17	glycemic	glycemic	ADJ
bptjm-46	92	18	condition	condition	NOUN
bptjm-46	92	19	,	,	PUNCT
bptjm-46	92	20	followed	follow	VERB
bptjm-46	92	21	by	by	ADP
bptjm-46	92	22	blocking	block	VERB
bptjm-46	92	23	products	product	NOUN
bptjm-46	92	24	from	from	ADP
bptjm-46	92	25	tca	tca	PROPN
bptjm-46	92	26	cycle	cycle	NOUN
bptjm-46	92	27	,	,	PUNCT
bptjm-46	92	28	resulting	result	VERB
bptjm-46	92	29	in	in	ADP
bptjm-46	92	30	high	high	ADJ
bptjm-46	92	31	amounts	amount	NOUN
bptjm-46	92	32	of	of	ADP
bptjm-46	92	33	lactate	lactate	NOUN
bptjm-46	92	34	production	production	NOUN
bptjm-46	92	35	.	.	PUNCT
bptjm-46	93	1	this	this	DET
bptjm-46	93	2	lactate	lactate	NOUN
bptjm-46	93	3	export	export	NOUN
bptjm-46	93	4	is	be	AUX
bptjm-46	93	5	then	then	ADV
bptjm-46	93	6	blocked	block	VERB
bptjm-46	93	7	,	,	PUNCT
bptjm-46	93	8	causing	cause	VERB
bptjm-46	93	9	intracellular	intracellular	ADJ
bptjm-46	93	10	acidi	acidi	NOUN
bptjm-46	93	11	�	�	NOUN
bptjm-46	93	12	cation	cation	NOUN
bptjm-46	93	13	and	and	CCONJ
bptjm-46	93	14	consequently	consequently	ADV
bptjm-46	93	15	cell	cell	NOUN
bptjm-46	93	16	death	death	NOUN
bptjm-46	93	17	.	.	PUNCT
bptjm-46	94	1	the	the	DET
bptjm-46	94	2	high	high	ADJ
bptjm-46	94	3	amount	amount	NOUN
bptjm-46	94	4	of	of	ADP
bptjm-46	94	5	lactate	lactate	NOUN
bptjm-46	94	6	can	can	AUX
bptjm-46	94	7	cause	cause	VERB
bptjm-46	94	8	a	a	DET
bptjm-46	94	9	strong	strong	ADJ
bptjm-46	94	10	acidi	acidi	NOUN
bptjm-46	94	11	�	�	PROPN
bptjm-46	94	12	cation	cation	NOUN
bptjm-46	94	13	process	process	NOUN
bptjm-46	94	14	,	,	PUNCT
bptjm-46	94	15	in	in	ADP
bptjm-46	94	16	which	which	PRON
bptjm-46	94	17	most	most	ADJ
bptjm-46	94	18	of	of	ADP
bptjm-46	94	19	the	the	DET
bptjm-46	94	20	normal	normal	ADJ
bptjm-46	94	21	cell	cell	NOUN
bptjm-46	94	22	functions	function	NOUN
bptjm-46	94	23	are	be	AUX
bptjm-46	94	24	inhibited	inhibit	VERB
bptjm-46	94	25	,	,	PUNCT
bptjm-46	94	26	including	include	VERB
bptjm-46	94	27	division	division	NOUN
bptjm-46	94	28	.	.	PUNCT
bptjm-46	95	1	the	the	DET
bptjm-46	95	2	high	high	ADJ
bptjm-46	95	3	amount	amount	NOUN
bptjm-46	95	4	of	of	ADP
bptjm-46	95	5	lactate	lactate	NOUN
bptjm-46	95	6	can	can	AUX
bptjm-46	95	7	cause	cause	VERB
bptjm-46	95	8	a	a	DET
bptjm-46	95	9	strong	strong	ADJ
bptjm-46	95	10	acidi	acidi	NOUN
bptjm-46	95	11	�	�	PROPN
bptjm-46	95	12	cation	cation	NOUN
bptjm-46	95	13	process	process	NOUN
bptjm-46	95	14	,	,	PUNCT
bptjm-46	95	15	in	in	ADP
bptjm-46	95	16	which	which	PRON
bptjm-46	95	17	most	most	ADJ
bptjm-46	95	18	of	of	ADP
bptjm-46	95	19	the	the	DET
bptjm-46	95	20	normal	normal	ADJ
bptjm-46	95	21	cell	cell	NOUN
bptjm-46	95	22	functions	function	NOUN
bptjm-46	95	23	are	be	AUX
bptjm-46	95	24	inhibited	inhibit	VERB
bptjm-46	95	25	,	,	PUNCT
bptjm-46	95	26	including	include	VERB
bptjm-46	95	27	division	division	NOUN
bptjm-46	95	28	.	.	PUNCT
bptjm-46	96	1	in	in	ADP
bptjm-46	96	2	addition	addition	NOUN
bptjm-46	96	3	,	,	PUNCT
bptjm-46	96	4	lactate	lactate	PROPN
bptjm-46	96	5	released	release	VERB
bptjm-46	96	6	from	from	ADP
bptjm-46	96	7	tumor	tumor	NOUN
bptjm-46	96	8	cells	cell	NOUN
bptjm-46	96	9	through	through	ADP
bptjm-46	96	10	monocarboxylate	monocarboxylate	ADJ
bptjm-46	96	11	transporter	transporter	NOUN
bptjm-46	96	12	4	4	NUM
bptjm-46	96	13	(	(	PUNCT
bptjm-46	96	14	mct4	mct4	PROPN
bptjm-46	96	15	)	)	PUNCT
bptjm-46	96	16	is	be	AUX
bptjm-46	96	17	enough	enough	ADJ
bptjm-46	96	18	to	to	PART
bptjm-46	96	19	stimulate	stimulate	VERB
bptjm-46	96	20	angiogenesis	angiogenesis	NOUN
bptjm-46	96	21	and	and	CCONJ
bptjm-46	96	22	tumor	tumor	NOUN
bptjm-46	96	23	growth	growth	NOUN
bptjm-46	96	24	.	.	PUNCT
bptjm-46	97	1	increased	increase	VERB
bptjm-46	97	2	lactic	lactic	ADJ
bptjm-46	97	3	acid	acid	NOUN
bptjm-46	97	4	can	can	AUX
bptjm-46	97	5	in	in	ADP
bptjm-46	97	6	turn	turn	NOUN
bptjm-46	97	7	enhance	enhance	VERB
bptjm-46	97	8	glycolysis	glycolysis	NOUN
bptjm-46	97	9	in	in	ADP
bptjm-46	97	10	cancer	cancer	NOUN
bptjm-46	97	11	cells	cell	NOUN
bptjm-46	97	12	,	,	PUNCT
bptjm-46	97	13	causing	cause	VERB
bptjm-46	97	14	a	a	DET
bptjm-46	97	15	vicious	vicious	ADJ
bptjm-46	97	16	cycle	cycle	NOUN
bptjm-46	97	17	.	.	PUNCT
bptjm-46	98	1	however	however	ADV
bptjm-46	98	2	,	,	PUNCT
bptjm-46	98	3	this	this	DET
bptjm-46	98	4	high	high	ADJ
bptjm-46	98	5	lactate	lactate	NOUN
bptjm-46	98	6	content	content	NOUN
bptjm-46	98	7	causes	cause	VERB
bptjm-46	98	8	normal	normal	ADJ
bptjm-46	98	9	cell	cell	NOUN
bptjm-46	98	10	functions	function	NOUN
bptjm-46	98	11	to	to	PART
bptjm-46	98	12	be	be	AUX
bptjm-46	98	13	inhibited	inhibit	VERB
bptjm-46	98	14	,	,	PUNCT
bptjm-46	98	15	including	include	VERB
bptjm-46	98	16	the	the	DET
bptjm-46	98	17	process	process	NOUN
bptjm-46	98	18	of	of	ADP
bptjm-46	98	19	replication	replication	NOUN
bptjm-46	98	20	and	and	CCONJ
bptjm-46	98	21	division	division	NOUN
bptjm-46	98	22	.	.	PUNCT
bptjm-46	99	1	using	use	VERB
bptjm-46	99	2	this	this	DET
bptjm-46	99	3	manner	manner	NOUN
bptjm-46	99	4	,	,	PUNCT
bptjm-46	99	5	a	a	DET
bptjm-46	99	6	treatment	treatment	NOUN
bptjm-46	99	7	of	of	ADP
bptjm-46	99	8	poisoning	poison	VERB
bptjm-46	99	9	the	the	DET
bptjm-46	99	10	cancer	cancer	NOUN
bptjm-46	99	11	cells	cell	NOUN
bptjm-46	99	12	is	be	AUX
bptjm-46	99	13	feasible	feasible	ADJ
bptjm-46	99	14	by	by	ADP
bptjm-46	99	15	inducing	induce	VERB
bptjm-46	99	16	over	over	ADP
bptjm-46	99	17	-	-	PUNCT
bptjm-46	99	18	production	production	NOUN
bptjm-46	99	19	of	of	ADP
bptjm-46	99	20	lactate	lactate	NOUN
bptjm-46	99	21	to	to	PART
bptjm-46	99	22	decrease	decrease	VERB
bptjm-46	99	23	ph	ph	ADJ
bptjm-46	99	24	level	level	NOUN
bptjm-46	99	25	.	.	PUNCT
bptjm-46	100	1	however	however	ADV
bptjm-46	100	2	,	,	PUNCT
bptjm-46	100	3	research	research	NOUN
bptjm-46	100	4	shows	show	VERB
bptjm-46	100	5	that	that	SCONJ
bptjm-46	100	6	a	a	DET
bptjm-46	100	7	highly	highly	ADV
bptjm-46	100	8	acidic	acidic	ADJ
bptjm-46	100	9	environment	environment	NOUN
bptjm-46	100	10	surrounding	surround	VERB
bptjm-46	100	11	the	the	DET
bptjm-46	100	12	tumor	tumor	NOUN
bptjm-46	100	13	is	be	AUX
bptjm-46	100	14	responsible	responsible	ADJ
bptjm-46	100	15	for	for	ADP
bptjm-46	100	16	the	the	DET
bptjm-46	100	17	development	development	NOUN
bptjm-46	100	18	of	of	ADP
bptjm-46	100	19	chemotherapy	chemotherapy	NOUN
bptjm-46	100	20	resistance	resistance	NOUN
bptjm-46	100	21	.	.	PUNCT
bptjm-46	101	1	thus	thus	ADV
bptjm-46	101	2	,	,	PUNCT
bptjm-46	101	3	two	two	NUM
bptjm-46	101	4	needs	need	NOUN
bptjm-46	101	5	that	that	PRON
bptjm-46	101	6	must	must	AUX
bptjm-46	101	7	be	be	AUX
bptjm-46	101	8	met	meet	VERB
bptjm-46	101	9	are	be	AUX
bptjm-46	101	10	to	to	PART
bptjm-46	101	11	increase	increase	VERB
bptjm-46	101	12	lactate	lactate	NOUN
bptjm-46	101	13	formation	formation	NOUN
bptjm-46	101	14	and	and	CCONJ
bptjm-46	101	15	block	block	VERB
bptjm-46	101	16	the	the	DET
bptjm-46	101	17	lactate	lactate	NOUN
bptjm-46	101	18	from	from	ADP
bptjm-46	101	19	exiting	exit	VERB
bptjm-46	101	20	the	the	DET
bptjm-46	101	21	cancer	cancer	NOUN
bptjm-46	101	22	cell	cell	NOUN
bptjm-46	101	23	.	.	PUNCT
bptjm-46	102	1	a	a	DET
bptjm-46	102	2	potential	potential	ADJ
bptjm-46	102	3	pathway	pathway	NOUN
bptjm-46	102	4	of	of	ADP
bptjm-46	102	5	this	this	DET
bptjm-46	102	6	treatment	treatment	NOUN
bptjm-46	102	7	is	be	AUX
bptjm-46	102	8	the	the	DET
bptjm-46	102	9	utilization	utilization	NOUN
bptjm-46	102	10	of	of	ADP
bptjm-46	102	11	monocarboxylate	monocarboxylate	ADJ
bptjm-46	102	12	transporter	transporter	NOUN
bptjm-46	102	13	4	4	NUM
bptjm-46	102	14	(	(	PUNCT
bptjm-46	102	15	mct4	mct4	PROPN
bptjm-46	102	16	)	)	PUNCT
bptjm-46	102	17	along	along	ADP
bptjm-46	102	18	with	with	ADP
bptjm-46	102	19	the	the	DET
bptjm-46	102	20	cannabinoid	cannabinoid	NOUN
bptjm-46	102	21	receptor	receptor	NOUN
bptjm-46	102	22	2	2	NUM
bptjm-46	102	23	(	(	PUNCT
bptjm-46	102	24	cb2).31	cb2).31	PROPN
bptjm-46	102	25	berkeley	berkeley	PROPN
bptjm-46	102	26	pharma	pharma	PROPN
bptjm-46	102	27	tech	tech	NOUN
bptjm-46	102	28	journal	journal	NOUN
bptjm-46	102	29	of	of	ADP
bptjm-46	102	30	medicine	medicine	NOUN
bptjm-46	102	31	|	|	ADV
bptjm-46	102	32	108	108	NUM
bptjm-46	102	33	monocarboxylate	monocarboxylate	ADJ
bptjm-46	102	34	transporter	transporter	NOUN
bptjm-46	102	35	4	4	NUM
bptjm-46	102	36	(	(	PUNCT
bptjm-46	102	37	mct4	mct4	PROPN
bptjm-46	102	38	)	)	PUNCT
bptjm-46	102	39	is	be	AUX
bptjm-46	102	40	highly	highly	ADV
bptjm-46	102	41	expressed	express	VERB
bptjm-46	102	42	in	in	ADP
bptjm-46	102	43	metastatic	metastatic	ADJ
bptjm-46	102	44	tumors	tumor	NOUN
bptjm-46	102	45	and	and	CCONJ
bptjm-46	102	46	at	at	ADP
bptjm-46	102	47	in	in	ADP
bptjm-46	102	48	�	�	NOUN
bptjm-46	102	49	ammatory	ammatory	NOUN
bptjm-46	102	50	sites	site	NOUN
bptjm-46	102	51	,	,	PUNCT
bptjm-46	102	52	referentially	referentially	ADV
bptjm-46	102	53	in	in	ADP
bptjm-46	102	54	glycolytic	glycolytic	ADJ
bptjm-46	102	55	muscle	muscle	NOUN
bptjm-46	102	56	�	�	NOUN
bptjm-46	102	57	bers	ber	NOUN
bptjm-46	102	58	and	and	CCONJ
bptjm-46	102	59	facilitating	facilitate	VERB
bptjm-46	102	60	the	the	DET
bptjm-46	102	61	lactate	lactate	NOUN
bptjm-46	102	62	e	e	NOUN
bptjm-46	102	63	�	�	PROPN
bptjm-46	102	64	ux	ux	PROPN
bptjm-46	102	65	.	.	PUNCT
bptjm-46	103	1	mct4	mct4	PROPN
bptjm-46	103	2	is	be	AUX
bptjm-46	103	3	responsible	responsible	ADJ
bptjm-46	103	4	for	for	ADP
bptjm-46	103	5	the	the	DET
bptjm-46	103	6	bidirectional	bidirectional	ADJ
bptjm-46	103	7	transport	transport	NOUN
bptjm-46	103	8	of	of	ADP
bptjm-46	103	9	lactate	lactate	NOUN
bptjm-46	103	10	across	across	ADP
bptjm-46	103	11	the	the	DET
bptjm-46	103	12	plasma	plasma	NOUN
bptjm-46	103	13	membrane	membrane	NOUN
bptjm-46	103	14	.	.	PUNCT
bptjm-46	104	1	the	the	DET
bptjm-46	104	2	cb2	cb2	PROPN
bptjm-46	104	3	receptor	receptor	NOUN
bptjm-46	104	4	modulates	modulate	NOUN
bptjm-46	104	5	immune	immune	ADJ
bptjm-46	104	6	cell	cell	NOUN
bptjm-46	104	7	functions	function	NOUN
bptjm-46	104	8	.	.	PUNCT
bptjm-46	105	1	cannabinoid	cannabinoid	NOUN
bptjm-46	105	2	receptors	receptor	NOUN
bptjm-46	105	3	(	(	PUNCT
bptjm-46	105	4	cb1	cb1	NOUN
bptjm-46	105	5	and	and	CCONJ
bptjm-46	105	6	cb2	cb2	PROPN
bptjm-46	105	7	)	)	PUNCT
bptjm-46	105	8	–	–	PUNCT
bptjm-46	105	9	g	g	NOUN
bptjm-46	105	10	-	-	PUNCT
bptjm-46	105	11	protein	protein	NOUN
bptjm-46	105	12	coupled	couple	VERB
bptjm-46	105	13	receptors	receptor	NOUN
bptjm-46	105	14	,	,	PUNCT
bptjm-46	105	15	inhibit	inhibit	VERB
bptjm-46	105	16	adenylate	adenylate	ADJ
bptjm-46	105	17	cyclase	cyclase	NOUN
bptjm-46	105	18	activity	activity	NOUN
bptjm-46	105	19	in	in	ADP
bptjm-46	105	20	response	response	NOUN
bptjm-46	105	21	to	to	ADP
bptjm-46	105	22	psychoactive	psychoactive	ADJ
bptjm-46	105	23	cannabinoids32	cannabinoids32	NOUN
bptjm-46	105	24	.	.	PUNCT
bptjm-46	106	1	the	the	DET
bptjm-46	106	2	activation	activation	NOUN
bptjm-46	106	3	of	of	ADP
bptjm-46	106	4	cb2	cb2	NOUN
bptjm-46	106	5	receptors	receptor	NOUN
bptjm-46	106	6	does	do	AUX
bptjm-46	106	7	not	not	PART
bptjm-46	106	8	appear	appear	VERB
bptjm-46	106	9	to	to	PART
bptjm-46	106	10	produce	produce	VERB
bptjm-46	106	11	psychotropic	psychotropic	ADJ
bptjm-46	106	12	e	e	NOUN
bptjm-46	106	13	�	�	NOUN
bptjm-46	106	14	ects	ect	NOUN
bptjm-46	106	15	,	,	PUNCT
bptjm-46	106	16	and	and	CCONJ
bptjm-46	106	17	therefore	therefore	ADV
bptjm-46	106	18	,	,	PUNCT
bptjm-46	106	19	it	it	PRON
bptjm-46	106	20	may	may	AUX
bptjm-46	106	21	also	also	ADV
bptjm-46	106	22	be	be	AUX
bptjm-46	106	23	helpful	helpful	ADJ
bptjm-46	106	24	in	in	ADP
bptjm-46	106	25	treating	treat	VERB
bptjm-46	106	26	diseases	disease	NOUN
bptjm-46	106	27	that	that	PRON
bptjm-46	106	28	have	have	VERB
bptjm-46	106	29	a	a	DET
bptjm-46	106	30	neuroin	neuroin	NOUN
bptjm-46	106	31	�	�	NOUN
bptjm-46	106	32	ammatory	ammatory	NOUN
bptjm-46	106	33	or	or	CCONJ
bptjm-46	106	34	neurodegenerative	neurodegenerative	ADJ
bptjm-46	106	35	component	component	NOUN
bptjm-46	106	36	,	,	PUNCT
bptjm-46	106	37	such	such	ADJ
bptjm-46	106	38	as	as	ADP
bptjm-46	106	39	multiple	multiple	ADJ
bptjm-46	106	40	sclerosis	sclerosis	NOUN
bptjm-46	106	41	.	.	PUNCT
bptjm-46	107	1	mapks	mapks	NOUN
bptjm-46	107	2	are	be	AUX
bptjm-46	107	3	enzymes	enzyme	NOUN
bptjm-46	107	4	involved	involve	VERB
bptjm-46	107	5	in	in	ADP
bptjm-46	107	6	a	a	DET
bptjm-46	107	7	wide	wide	ADJ
bptjm-46	107	8	variety	variety	NOUN
bptjm-46	107	9	of	of	ADP
bptjm-46	107	10	important	important	ADJ
bptjm-46	107	11	signaling	signal	VERB
bptjm-46	107	12	cascades	cascade	NOUN
bptjm-46	107	13	in	in	ADP
bptjm-46	107	14	many	many	ADJ
bptjm-46	107	15	cellular	cellular	ADJ
bptjm-46	107	16	responses	response	NOUN
bptjm-46	107	17	–	–	PUNCT
bptjm-46	107	18	cell	cell	NOUN
bptjm-46	107	19	proliferation	proliferation	NOUN
bptjm-46	107	20	,	,	PUNCT
bptjm-46	107	21	migration	migration	NOUN
bptjm-46	107	22	,	,	PUNCT
bptjm-46	107	23	transformation	transformation	NOUN
bptjm-46	107	24	,	,	PUNCT
bptjm-46	107	25	and	and	CCONJ
bptjm-46	107	26	cell	cell	NOUN
bptjm-46	107	27	death	death	NOUN
bptjm-46	107	28	.	.	PUNCT
bptjm-46	108	1	mapk	mapk	NOUN
bptjm-46	108	2	activation	activation	NOUN
bptjm-46	108	3	by	by	ADP
bptjm-46	108	4	a	a	DET
bptjm-46	108	5	nonselective	nonselective	ADJ
bptjm-46	108	6	cb2	cb2	NOUN
bptjm-46	108	7	receptor	receptor	NOUN
bptjm-46	108	8	agonist	agonist	NOUN
bptjm-46	108	9	(	(	PUNCT
bptjm-46	108	10	d9	d9	PROPN
bptjm-46	108	11	-	-	PUNCT
bptjm-46	108	12	thc	thc	NOUN
bptjm-46	108	13	)	)	PUNCT
bptjm-46	108	14	was	be	AUX
bptjm-46	108	15	found	find	VERB
bptjm-46	108	16	to	to	PART
bptjm-46	108	17	have	have	VERB
bptjm-46	108	18	a	a	DET
bptjm-46	108	19	proapoptotic	proapoptotic	ADJ
bptjm-46	108	20	e	e	NOUN
bptjm-46	108	21	�	�	NOUN
bptjm-46	108	22	ect	ect	VERB
bptjm-46	108	23	in	in	ADP
bptjm-46	108	24	the	the	DET
bptjm-46	108	25	jurkat	jurkat	PROPN
bptjm-46	108	26	human	human	PROPN
bptjm-46	108	27	leukemia	leukemia	PROPN
bptjm-46	108	28	cell	cell	NOUN
bptjm-46	108	29	line	line	NOUN
bptjm-46	108	30	(	(	PUNCT
bptjm-46	108	31	herrera	herrera	NOUN
bptjm-46	108	32	et	et	PROPN
bptjm-46	108	33	al	al	PROPN
bptjm-46	108	34	.	.	PROPN
bptjm-46	108	35	,	,	PUNCT
bptjm-46	108	36	2005	2005	NUM
bptjm-46	108	37	)	)	PUNCT
bptjm-46	108	38	and	and	CCONJ
bptjm-46	108	39	cytotoxicity	cytotoxicity	NOUN
bptjm-46	108	40	in	in	ADP
bptjm-46	108	41	j774	j774	PROPN
bptjm-46	108	42	-	-	SYM
bptjm-46	108	43	1	1	NUM
bptjm-46	108	44	macrophages	macrophage	NOUN
bptjm-46	108	45	;	;	PUNCT
bptjm-46	108	46	in	in	ADP
bptjm-46	108	47	the	the	DET
bptjm-46	108	48	same	same	ADJ
bptjm-46	108	49	cells	cell	NOUN
bptjm-46	108	50	,	,	PUNCT
bptjm-46	108	51	there	there	PRON
bptjm-46	108	52	was	be	VERB
bptjm-46	108	53	also	also	ADV
bptjm-46	108	54	a	a	DET
bptjm-46	108	55	c	c	PROPN
bptjm-46	108	56	-	-	PUNCT
bptjm-46	108	57	jun	jun	PROPN
bptjm-46	108	58	n	n	CCONJ
bptjm-46	108	59	-	-	PUNCT
bptjm-46	108	60	terminal	terminal	ADJ
bptjm-46	108	61	kinase	kinase	NOUN
bptjm-46	108	62	–	–	PUNCT
bptjm-46	108	63	mediated	mediate	VERB
bptjm-46	108	64	cytoprotective	cytoprotective	ADJ
bptjm-46	108	65	e	e	X
bptjm-46	108	66	�	�	NOUN
bptjm-46	108	67	ect	ect	VERB
bptjm-46	108	68	mediated	mediate	VERB
bptjm-46	108	69	by	by	ADP
bptjm-46	108	70	δ9	δ9	NOUN
bptjm-46	108	71	-	-	PUNCT
bptjm-46	108	72	thc	thc	NOUN
bptjm-46	108	73	activation	activation	NOUN
bptjm-46	108	74	of	of	ADP
bptjm-46	108	75	cb2	cb2	PROPN
bptjm-46	108	76	receptors	receptor	NOUN
bptjm-46	108	77	,	,	PUNCT
bptjm-46	108	78	displaying	display	VERB
bptjm-46	108	79	the	the	DET
bptjm-46	108	80	same	same	ADJ
bptjm-46	108	81	cb2	cb2	NOUN
bptjm-46	108	82	receptor	receptor	NOUN
bptjm-46	108	83	ligand	ligand	NOUN
bptjm-46	108	84	can	can	AUX
bptjm-46	108	85	activate	activate	VERB
bptjm-46	108	86	multiple	multiple	ADJ
bptjm-46	108	87	mapks	mapks	NOUN
bptjm-46	108	88	,	,	PUNCT
bptjm-46	108	89	each	each	PRON
bptjm-46	108	90	with	with	ADP
bptjm-46	108	91	di	di	NOUN
bptjm-46	108	92	�	�	PROPN
bptjm-46	108	93	erent	erent	NOUN
bptjm-46	108	94	outcomes33	outcomes33	NOUN
bptjm-46	108	95	.	.	PUNCT
bptjm-46	109	1	the	the	DET
bptjm-46	109	2	activation	activation	NOUN
bptjm-46	109	3	of	of	ADP
bptjm-46	109	4	cb2	cb2	NOUN
bptjm-46	109	5	receptors	receptor	NOUN
bptjm-46	109	6	by	by	ADP
bptjm-46	109	7	natural	natural	ADJ
bptjm-46	109	8	or	or	CCONJ
bptjm-46	109	9	synthetic	synthetic	ADJ
bptjm-46	109	10	ligands	ligand	NOUN
bptjm-46	109	11	favors	favor	VERB
bptjm-46	109	12	a	a	DET
bptjm-46	109	13	range	range	NOUN
bptjm-46	109	14	of	of	ADP
bptjm-46	109	15	receptor	receptor	NOUN
bptjm-46	109	16	conformations	conformation	NOUN
bptjm-46	109	17	that	that	PRON
bptjm-46	109	18	can	can	AUX
bptjm-46	109	19	variably	variably	ADV
bptjm-46	109	20	a	a	DET
bptjm-46	109	21	�	�	PROPN
bptjm-46	109	22	ect	ect	ADJ
bptjm-46	109	23	di	di	PROPN
bptjm-46	109	24	�	�	PROPN
bptjm-46	109	25	erent	erent	NOUN
bptjm-46	109	26	signaling	signal	VERB
bptjm-46	109	27	pathways	pathway	NOUN
bptjm-46	109	28	as	as	ADP
bptjm-46	109	29	the	the	DET
bptjm-46	109	30	following	follow	VERB
bptjm-46	109	31	procedure	procedure	NOUN
bptjm-46	109	32	–	–	PUNCT
bptjm-46	109	33	inhibition	inhibition	NOUN
bptjm-46	109	34	of	of	ADP
bptjm-46	109	35	adenylyl	adenylyl	ADJ
bptjm-46	109	36	cyclase	cyclase	NOUN
bptjm-46	109	37	,	,	PUNCT
bptjm-46	109	38	decreased	decrease	VERB
bptjm-46	109	39	camp	camp	NOUN
bptjm-46	109	40	(	(	PUNCT
bptjm-46	109	41	production	production	NOUN
bptjm-46	109	42	,	,	PUNCT
bptjm-46	109	43	and	and	CCONJ
bptjm-46	109	44	less	less	ADJ
bptjm-46	109	45	activation	activation	NOUN
bptjm-46	109	46	of	of	ADP
bptjm-46	109	47	camp	camp	NOUN
bptjm-46	109	48	-	-	PUNCT
bptjm-46	109	49	dependent	dependent	ADJ
bptjm-46	109	50	protein	protein	NOUN
bptjm-46	109	51	kinase	kinase	NOUN
bptjm-46	109	52	(	(	PUNCT
bptjm-46	109	53	pka	pka	PROPN
bptjm-46	109	54	)	)	PUNCT
bptjm-46	109	55	,	,	PUNCT
bptjm-46	109	56	inhibiting	inhibit	VERB
bptjm-46	109	57	a	a	DET
bptjm-46	109	58	-	-	PUNCT
bptjm-46	109	59	type	type	NOUN
bptjm-46	109	60	potassium	potassium	NOUN
bptjm-46	109	61	channels	channel	NOUN
bptjm-46	109	62	as	as	ADV
bptjm-46	109	63	well	well	ADV
bptjm-46	109	64	as	as	ADP
bptjm-46	109	65	speci	speci	PROPN
bptjm-46	109	66	�	�	PROPN
bptjm-46	109	67	c	c	NOUN
bptjm-46	109	68	gene	gene	NOUN
bptjm-46	109	69	expression	expression	NOUN
bptjm-46	109	70	.	.	PUNCT
bptjm-46	110	1	this	this	PRON
bptjm-46	110	2	is	be	AUX
bptjm-46	110	3	followed	follow	VERB
bptjm-46	110	4	by	by	ADP
bptjm-46	110	5	activation	activation	NOUN
bptjm-46	110	6	of	of	ADP
bptjm-46	110	7	akt	akt	PROPN
bptjm-46	110	8	/	/	SYM
bptjm-46	110	9	protein	protein	NOUN
bptjm-46	110	10	kinase	kinase	NOUN
bptjm-46	110	11	b	b	PROPN
bptjm-46	110	12	–	–	PUNCT
bptjm-46	110	13	stimulating	stimulate	VERB
bptjm-46	110	14	cell	cell	NOUN
bptjm-46	110	15	survival	survival	NOUN
bptjm-46	110	16	,	,	PUNCT
bptjm-46	110	17	migration	migration	NOUN
bptjm-46	110	18	,	,	PUNCT
bptjm-46	110	19	and	and	CCONJ
bptjm-46	110	20	growth	growth	NOUN
bptjm-46	110	21	.	.	PUNCT
bptjm-46	111	1	proceeding	proceed	VERB
bptjm-46	111	2	activation	activation	NOUN
bptjm-46	111	3	of	of	ADP
bptjm-46	111	4	the	the	DET
bptjm-46	111	5	mitogen	mitogen	NOUN
bptjm-46	111	6	-	-	PUNCT
bptjm-46	111	7	activated	activate	VERB
bptjm-46	111	8	protein	protein	NOUN
bptjm-46	111	9	kinase	kinase	NOUN
bptjm-46	111	10	(	(	PUNCT
bptjm-46	111	11	mapk	mapk	NOUN
bptjm-46	111	12	)	)	PUNCT
bptjm-46	111	13	cascade	cascade	NOUN
bptjm-46	111	14	favors	favor	VERB
bptjm-46	111	15	cell	cell	NOUN
bptjm-46	111	16	survival	survival	NOUN
bptjm-46	111	17	and	and	CCONJ
bptjm-46	111	18	modulates	modulate	VERB
bptjm-46	111	19	gene	gene	NOUN
bptjm-46	111	20	expression	expression	NOUN
bptjm-46	111	21	.	.	PUNCT
bptjm-46	112	1	in	in	ADP
bptjm-46	112	2	addition	addition	NOUN
bptjm-46	112	3	,	,	PUNCT
bptjm-46	112	4	there	there	PRON
bptjm-46	112	5	is	be	VERB
bptjm-46	112	6	inhibition	inhibition	NOUN
bptjm-46	112	7	of	of	ADP
bptjm-46	112	8	speci	speci	PROPN
bptjm-46	112	9	�	�	PROPN
bptjm-46	112	10	c	c	NOUN
bptjm-46	112	11	calcium	calcium	NOUN
bptjm-46	112	12	channels	channel	NOUN
bptjm-46	112	13	and	and	CCONJ
bptjm-46	112	14	enhanced	enhance	VERB
bptjm-46	112	15	opening	opening	NOUN
bptjm-46	112	16	of	of	ADP
bptjm-46	112	17	g	g	PROPN
bptjm-46	112	18	protein	protein	NOUN
bptjm-46	112	19	–	–	PUNCT
bptjm-46	112	20	gated	gate	VERB
bptjm-46	112	21	inwardly	inwardly	ADV
bptjm-46	112	22	rectifying	rectify	VERB
bptjm-46	112	23	potassium	potassium	NOUN
bptjm-46	112	24	(	(	PUNCT
bptjm-46	112	25	girk	girk	ADJ
bptjm-46	112	26	)	)	PUNCT
bptjm-46	112	27	channels	channel	NOUN
bptjm-46	112	28	.	.	PUNCT
bptjm-46	113	1	lastly	lastly	ADV
bptjm-46	113	2	,	,	PUNCT
bptjm-46	113	3	stimulation	stimulation	NOUN
bptjm-46	113	4	of	of	ADP
bptjm-46	113	5	de	de	X
bptjm-46	113	6	novo	novo	NOUN
bptjm-46	113	7	synthesis	synthesis	NOUN
bptjm-46	113	8	of	of	ADP
bptjm-46	113	9	ceramide	ceramide	NOUN
bptjm-46	113	10	and	and	CCONJ
bptjm-46	113	11	inhibition	inhibition	NOUN
bptjm-46	113	12	of	of	ADP
bptjm-46	113	13	the	the	DET
bptjm-46	113	14	mapk	mapk	NOUN
bptjm-46	113	15	cascade	cascade	NOUN
bptjm-46	113	16	promotes	promote	VERB
bptjm-46	113	17	apoptosis34,35	apoptosis34,35	PROPN
bptjm-46	113	18	.	.	PUNCT
bptjm-46	114	1	recruitment	recruitment	NOUN
bptjm-46	114	2	of	of	ADP
bptjm-46	114	3	b	b	NOUN
bptjm-46	114	4	-	-	PUNCT
bptjm-46	114	5	arrestin	arrestin	NOUN
bptjm-46	114	6	to	to	ADP
bptjm-46	114	7	the	the	DET
bptjm-46	114	8	activated	activate	VERB
bptjm-46	114	9	cb2	cb2	NOUN
bptjm-46	114	10	receptor	receptor	NOUN
bptjm-46	114	11	results	result	NOUN
bptjm-46	114	12	in	in	ADP
bptjm-46	114	13	desensitization	desensitization	NOUN
bptjm-46	114	14	and/or	and/or	CCONJ
bptjm-46	114	15	internalization	internalization	NOUN
bptjm-46	114	16	of	of	ADP
bptjm-46	114	17	the	the	DET
bptjm-46	114	18	receptor	receptor	NOUN
bptjm-46	114	19	and	and	CCONJ
bptjm-46	114	20	potential	potential	ADJ
bptjm-46	114	21	activation	activation	NOUN
bptjm-46	114	22	of	of	ADP
bptjm-46	114	23	arrestin	arrestin	NOUN
bptjm-46	114	24	-	-	PUNCT
bptjm-46	114	25	speci	speci	NOUN
bptjm-46	114	26	�	�	PROPN
bptjm-46	114	27	c	c	PART
bptjm-46	114	28	signaling	signaling	NOUN
bptjm-46	114	29	.	.	PUNCT
bptjm-46	115	1	decreased	decrease	VERB
bptjm-46	115	2	pka	pka	NOUN
bptjm-46	115	3	activity	activity	NOUN
bptjm-46	115	4	increases	increase	VERB
bptjm-46	115	5	raf-1	raf-1	ADV
bptjm-46	115	6	to	to	PART
bptjm-46	115	7	stimulate	stimulate	VERB
bptjm-46	115	8	the	the	DET
bptjm-46	115	9	mapk	mapk	NOUN
bptjm-46	115	10	cascade	cascade	NOUN
bptjm-46	115	11	,	,	PUNCT
bptjm-46	115	12	positively	positively	ADV
bptjm-46	115	13	regulating	regulate	VERB
bptjm-46	115	14	the	the	DET
bptjm-46	115	15	berkeley	berkeley	PROPN
bptjm-46	115	16	pharma	pharma	PROPN
bptjm-46	115	17	tech	tech	NOUN
bptjm-46	115	18	journal	journal	NOUN
bptjm-46	115	19	of	of	ADP
bptjm-46	115	20	medicine	medicine	NOUN
bptjm-46	115	21	|	|	ADV
bptjm-46	115	22	109	109	NUM
bptjm-46	115	23	expression	expression	NOUN
bptjm-46	115	24	of	of	ADP
bptjm-46	115	25	many	many	ADJ
bptjm-46	115	26	genes	gene	NOUN
bptjm-46	115	27	and	and	CCONJ
bptjm-46	115	28	indicating	indicate	VERB
bptjm-46	115	29	activation	activation	NOUN
bptjm-46	115	30	of	of	ADP
bptjm-46	115	31	a	a	DET
bptjm-46	115	32	pathway	pathway	NOUN
bptjm-46	115	33	by	by	ADP
bptjm-46	115	34	cb2	cb2	PROPN
bptjm-46	115	35	receptor	receptor	NOUN
bptjm-46	115	36	agonists	agonist	NOUN
bptjm-46	115	37	.	.	PUNCT
bptjm-46	116	1	functional	functional	ADJ
bptjm-46	116	2	selectivity	selectivity	NOUN
bptjm-46	116	3	of	of	ADP
bptjm-46	116	4	cb2	cb2	PROPN
bptjm-46	116	5	receptor	receptor	NOUN
bptjm-46	116	6	agonists	agonist	NOUN
bptjm-46	116	7	must	must	AUX
bptjm-46	116	8	be	be	AUX
bptjm-46	116	9	considered	consider	VERB
bptjm-46	116	10	during	during	ADP
bptjm-46	116	11	the	the	DET
bptjm-46	116	12	therapeutic	therapeutic	ADJ
bptjm-46	116	13	development	development	NOUN
bptjm-46	116	14	of	of	ADP
bptjm-46	116	15	cb2	cb2	PROPN
bptjm-46	116	16	agonists	agonist	NOUN
bptjm-46	116	17	,	,	PUNCT
bptjm-46	116	18	which	which	PRON
bptjm-46	116	19	increases	increase	VERB
bptjm-46	116	20	the	the	DET
bptjm-46	116	21	possibilities	possibility	NOUN
bptjm-46	116	22	for	for	ADP
bptjm-46	116	23	developing	develop	VERB
bptjm-46	116	24	drugs	drug	NOUN
bptjm-46	116	25	targeting	target	VERB
bptjm-46	116	26	cb2	cb2	NOUN
bptjm-46	116	27	receptors	receptor	NOUN
bptjm-46	116	28	.	.	PUNCT
bptjm-46	117	1	by	by	ADP
bptjm-46	117	2	forcing	force	VERB
bptjm-46	117	3	glycolysis	glycolysis	NOUN
bptjm-46	117	4	with	with	ADP
bptjm-46	117	5	metformin	metformin	NOUN
bptjm-46	117	6	and	and	CCONJ
bptjm-46	117	7	a	a	DET
bptjm-46	117	8	nf	nf	ADJ
bptjm-46	117	9	-	-	PUNCT
bptjm-46	117	10	kb	kb	NOUN
bptjm-46	117	11	inhibitor	inhibitor	NOUN
bptjm-46	117	12	lowers	lower	VERB
bptjm-46	117	13	the	the	DET
bptjm-46	117	14	ph	ph	NOUN
bptjm-46	117	15	of	of	ADP
bptjm-46	117	16	a	a	DET
bptjm-46	117	17	cell	cell	NOUN
bptjm-46	117	18	,	,	PUNCT
bptjm-46	117	19	our	our	PRON
bptjm-46	117	20	treatment	treatment	NOUN
bptjm-46	117	21	has	have	VERB
bptjm-46	117	22	a	a	DET
bptjm-46	117	23	minor	minor	ADJ
bptjm-46	117	24	e	e	NOUN
bptjm-46	117	25	�	�	NOUN
bptjm-46	117	26	ect	ect	X
bptjm-46	117	27	on	on	ADP
bptjm-46	117	28	normal	normal	ADJ
bptjm-46	117	29	cells	cell	NOUN
bptjm-46	117	30	and	and	CCONJ
bptjm-46	117	31	most	most	ADJ
bptjm-46	117	32	e	e	NOUN
bptjm-46	117	33	�	�	NOUN
bptjm-46	117	34	ective	ective	ADJ
bptjm-46	117	35	in	in	ADP
bptjm-46	117	36	cancer	cancer	NOUN
bptjm-46	117	37	patients	patient	NOUN
bptjm-46	117	38	with	with	ADP
bptjm-46	117	39	any	any	DET
bptjm-46	117	40	hyperglycemic	hyperglycemic	ADJ
bptjm-46	117	41	stages	stage	NOUN
bptjm-46	117	42	,	,	PUNCT
bptjm-46	117	43	including	include	VERB
bptjm-46	117	44	.	.	PUNCT
bptjm-46	118	1	as	as	ADP
bptjm-46	118	2	an	an	DET
bptjm-46	118	3	example	example	NOUN
bptjm-46	118	4	,	,	PUNCT
bptjm-46	118	5	nk	nk	PROPN
bptjm-46	118	6	-	-	PUNCT
bptjm-46	118	7	kb	kb	PROPN
bptjm-46	118	8	inhibition	inhibition	NOUN
bptjm-46	118	9	causes	cause	VERB
bptjm-46	118	10	increased	increase	VERB
bptjm-46	118	11	lactate	lactate	NOUN
bptjm-46	118	12	secretion	secretion	NOUN
bptjm-46	118	13	from	from	ADP
bptjm-46	118	14	breast	breast	NOUN
bptjm-46	118	15	cancer	cancer	NOUN
bptjm-46	118	16	cell	cell	NOUN
bptjm-46	118	17	line	line	NOUN
bptjm-46	118	18	mcf-736,37	mcf-736,37	PROPN
bptjm-46	118	19	.	.	PUNCT
bptjm-46	119	1	the	the	DET
bptjm-46	119	2	e	e	X
bptjm-46	119	3	�	�	NOUN
bptjm-46	119	4	ect	ect	VERB
bptjm-46	119	5	of	of	ADP
bptjm-46	119	6	this	this	DET
bptjm-46	119	7	metabolic	metabolic	NOUN
bptjm-46	119	8	reprogramming	reprogramme	VERB
bptjm-46	119	9	strategy	strategy	NOUN
bptjm-46	119	10	was	be	AUX
bptjm-46	119	11	observed	observe	VERB
bptjm-46	119	12	by	by	ADP
bptjm-46	119	13	checking	check	VERB
bptjm-46	119	14	oxygen	oxygen	NOUN
bptjm-46	119	15	consumption	consumption	NOUN
bptjm-46	119	16	and	and	CCONJ
bptjm-46	119	17	extracellular	extracellular	ADJ
bptjm-46	119	18	acidi	acidi	NOUN
bptjm-46	119	19	�	�	NOUN
bptjm-46	119	20	cation	cation	NOUN
bptjm-46	119	21	rates	rate	NOUN
bptjm-46	119	22	.	.	PUNCT
bptjm-46	120	1	this	this	PRON
bptjm-46	120	2	resulted	result	VERB
bptjm-46	120	3	in	in	ADP
bptjm-46	120	4	reduced	reduced	ADJ
bptjm-46	120	5	ocr	ocr	PROPN
bptjm-46	120	6	and	and	CCONJ
bptjm-46	120	7	blocked	block	VERB
bptjm-46	120	8	ecar	ecar	NOUN
bptjm-46	120	9	,	,	PUNCT
bptjm-46	120	10	essentially	essentially	ADV
bptjm-46	120	11	leading	lead	VERB
bptjm-46	120	12	to	to	ADP
bptjm-46	120	13	an	an	DET
bptjm-46	120	14	accumulation	accumulation	NOUN
bptjm-46	120	15	of	of	ADP
bptjm-46	120	16	lactate	lactate	NOUN
bptjm-46	120	17	.	.	PUNCT
bptjm-46	121	1	fluorescent	fluorescent	PROPN
bptjm-46	121	2	bcfl	bcfl	NOUN
bptjm-46	121	3	-	-	PUNCT
bptjm-46	121	4	am	am	NOUN
bptjm-46	121	5	was	be	AUX
bptjm-46	121	6	used	use	VERB
bptjm-46	121	7	as	as	ADP
bptjm-46	121	8	a	a	DET
bptjm-46	121	9	probe	probe	NOUN
bptjm-46	121	10	for	for	ADP
bptjm-46	121	11	detecting	detect	VERB
bptjm-46	121	12	phi	phi	NOUN
bptjm-46	121	13	.	.	PUNCT
bptjm-46	122	1	therefore	therefore	ADV
bptjm-46	122	2	,	,	PUNCT
bptjm-46	122	3	the	the	DET
bptjm-46	122	4	reprogramming	reprogramming	NOUN
bptjm-46	122	5	did	do	AUX
bptjm-46	122	6	not	not	PART
bptjm-46	122	7	decrease	decrease	VERB
bptjm-46	122	8	viability	viability	NOUN
bptjm-46	122	9	in	in	ADP
bptjm-46	122	10	(	(	PUNCT
bptjm-46	122	11	normal	normal	ADJ
bptjm-46	122	12	)	)	PUNCT
bptjm-46	122	13	mcf-12a	mcf-12a	NUM
bptjm-46	122	14	cells	cell	NOUN
bptjm-46	122	15	.	.	PUNCT
bptjm-46	123	1	it	it	PRON
bptjm-46	123	2	did	do	VERB
bptjm-46	123	3	,	,	PUNCT
bptjm-46	123	4	however	however	ADV
bptjm-46	123	5	,	,	PUNCT
bptjm-46	123	6	a	a	DET
bptjm-46	123	7	�	�	NOUN
bptjm-46	123	8	ect	ect	NOUN
bptjm-46	123	9	mcf-7	mcf-7	NOUN
bptjm-46	123	10	,	,	PUNCT
bptjm-46	123	11	t47d	t47d	PRON
bptjm-46	123	12	,	,	PUNCT
bptjm-46	123	13	and	and	CCONJ
bptjm-46	123	14	mda	mda	PROPN
bptjm-46	123	15	-	-	PUNCT
bptjm-46	123	16	mb-231	mb-231	PROPN
bptjm-46	123	17	(	(	PUNCT
bptjm-46	123	18	breast	breast	NOUN
bptjm-46	123	19	cancer	cancer	NOUN
bptjm-46	123	20	cells	cell	NOUN
bptjm-46	123	21	)	)	PUNCT
bptjm-46	123	22	,	,	PUNCT
bptjm-46	123	23	demonstrating	demonstrate	VERB
bptjm-46	123	24	signi	signi	PROPN
bptjm-46	123	25	�	�	PROPN
bptjm-46	123	26	cantly	cantly	ADV
bptjm-46	123	27	inhibited	inhibit	VERB
bptjm-46	123	28	migration	migration	NOUN
bptjm-46	123	29	and	and	CCONJ
bptjm-46	123	30	invasion	invasion	NOUN
bptjm-46	123	31	ability38	ability38	NOUN
bptjm-46	123	32	.	.	PUNCT
bptjm-46	124	1	consequently	consequently	ADV
bptjm-46	124	2	,	,	PUNCT
bptjm-46	124	3	in	in	ADP
bptjm-46	124	4	high	high	ADJ
bptjm-46	124	5	glucose	glucose	NOUN
bptjm-46	124	6	cancer	cancer	NOUN
bptjm-46	124	7	cells	cell	NOUN
bptjm-46	124	8	,	,	PUNCT
bptjm-46	124	9	a	a	DET
bptjm-46	124	10	higher	high	ADJ
bptjm-46	124	11	glycolysis	glycolysis	NOUN
bptjm-46	124	12	rate	rate	NOUN
bptjm-46	124	13	is	be	AUX
bptjm-46	124	14	present	present	ADJ
bptjm-46	124	15	,	,	PUNCT
bptjm-46	124	16	allowing	allow	VERB
bptjm-46	124	17	the	the	DET
bptjm-46	124	18	reprogramming	reprogramme	VERB
bptjm-46	124	19	strategy	strategy	NOUN
bptjm-46	124	20	to	to	PART
bptjm-46	124	21	further	far	ADV
bptjm-46	124	22	promote	promote	VERB
bptjm-46	124	23	the	the	DET
bptjm-46	124	24	process	process	NOUN
bptjm-46	124	25	and	and	CCONJ
bptjm-46	124	26	raise	raise	VERB
bptjm-46	124	27	intracellular	intracellular	ADJ
bptjm-46	124	28	lactate	lactate	NOUN
bptjm-46	124	29	,	,	PUNCT
bptjm-46	124	30	permitting	permit	VERB
bptjm-46	124	31	cancer	cancer	NOUN
bptjm-46	124	32	cells	cell	NOUN
bptjm-46	124	33	to	to	PART
bptjm-46	124	34	poison	poison	VERB
bptjm-46	124	35	themselves	themselves	PRON
bptjm-46	124	36	.	.	PUNCT
bptjm-46	125	1	essentially	essentially	ADV
bptjm-46	125	2	,	,	PUNCT
bptjm-46	125	3	there	there	PRON
bptjm-46	125	4	is	be	VERB
bptjm-46	125	5	limited	limit	VERB
bptjm-46	125	6	cytotoxic	cytotoxic	ADJ
bptjm-46	125	7	e	e	NOUN
bptjm-46	125	8	�	�	NOUN
bptjm-46	125	9	ect	ect	VERB
bptjm-46	125	10	on	on	ADP
bptjm-46	125	11	non	non	ADJ
bptjm-46	125	12	-	-	ADJ
bptjm-46	125	13	subject	subject	ADJ
bptjm-46	125	14	cells	cell	NOUN
bptjm-46	125	15	,	,	PUNCT
bptjm-46	125	16	reducing	reduce	VERB
bptjm-46	125	17	the	the	DET
bptjm-46	125	18	chance	chance	NOUN
bptjm-46	125	19	of	of	ADP
bptjm-46	125	20	untargeted	untargeted	ADJ
bptjm-46	125	21	damage	damage	NOUN
bptjm-46	125	22	.	.	PUNCT
bptjm-46	126	1	cb-2	cb-2	PROPN
bptjm-46	126	2	might	might	AUX
bptjm-46	126	3	bind	bind	VERB
bptjm-46	126	4	to	to	ADP
bptjm-46	126	5	a	a	DET
bptjm-46	126	6	pocket	pocket	NOUN
bptjm-46	126	7	of	of	ADP
bptjm-46	126	8	mct4	mct4	PROPN
bptjm-46	126	9	composed	compose	VERB
bptjm-46	126	10	of	of	ADP
bptjm-46	126	11	ser156	ser156	PROPN
bptjm-46	126	12	,	,	PUNCT
bptjm-46	126	13	phe243	phe243	PROPN
bptjm-46	126	14	,	,	PUNCT
bptjm-46	126	15	tyr332	tyr332	PROPN
bptjm-46	126	16	,	,	PUNCT
bptjm-46	126	17	gln339	gln339	PROPN
bptjm-46	126	18	and	and	CCONJ
bptjm-46	126	19	glu363	glu363	PROPN
bptjm-46	126	20	.	.	PUNCT
bptjm-46	127	1	the	the	DET
bptjm-46	127	2	combination	combination	NOUN
bptjm-46	127	3	of	of	ADP
bptjm-46	127	4	metformin	metformin	NOUN
bptjm-46	127	5	and	and	CCONJ
bptjm-46	127	6	cb-2	cb-2	ADV
bptjm-46	127	7	exerts	exert	VERB
bptjm-46	127	8	a	a	DET
bptjm-46	127	9	deleterious	deleterious	ADJ
bptjm-46	127	10	e	e	NOUN
bptjm-46	127	11	�	�	NOUN
bptjm-46	127	12	ect	ect	VERB
bptjm-46	127	13	on	on	ADP
bptjm-46	127	14	breast	breast	NOUN
bptjm-46	127	15	cancer	cancer	NOUN
bptjm-46	127	16	cell	cell	NOUN
bptjm-46	127	17	viability	viability	NOUN
bptjm-46	127	18	and	and	CCONJ
bptjm-46	127	19	exhibits	exhibit	VERB
bptjm-46	127	20	synergistic	synergistic	ADJ
bptjm-46	127	21	antitumor	antitumor	PROPN
bptjm-46	127	22	e	e	SYM
bptjm-46	127	23	�	�	NOUN
bptjm-46	127	24	ects	ect	NOUN
bptjm-46	127	25	.	.	PUNCT
bptjm-46	128	1	results	result	NOUN
bptjm-46	128	2	of	of	ADP
bptjm-46	128	3	the	the	DET
bptjm-46	128	4	combination	combination	NOUN
bptjm-46	128	5	treatment	treatment	NOUN
bptjm-46	128	6	showed	show	VERB
bptjm-46	128	7	a	a	DET
bptjm-46	128	8	63	63	NUM
bptjm-46	128	9	%	%	NOUN
bptjm-46	128	10	inhibition	inhibition	NOUN
bptjm-46	128	11	of	of	ADP
bptjm-46	128	12	cell	cell	NOUN
bptjm-46	128	13	viability	viability	NOUN
bptjm-46	128	14	in	in	ADP
bptjm-46	128	15	mda	mda	PROPN
bptjm-46	128	16	-	-	PUNCT
bptjm-46	128	17	mb-231	mb-231	PROPN
bptjm-46	128	18	breast	breast	NOUN
bptjm-46	128	19	cancer	cancer	NOUN
bptjm-46	128	20	cells39	cells39	PROPN
bptjm-46	128	21	.	.	PUNCT
bptjm-46	129	1	in	in	ADP
bptjm-46	129	2	addition	addition	NOUN
bptjm-46	129	3	,	,	PUNCT
bptjm-46	129	4	moderate	moderate	ADJ
bptjm-46	129	5	e	e	NOUN
bptjm-46	129	6	�	�	NOUN
bptjm-46	129	7	ect	ect	VERB
bptjm-46	129	8	on	on	ADP
bptjm-46	129	9	cell	cell	NOUN
bptjm-46	129	10	viability	viability	NOUN
bptjm-46	129	11	was	be	AUX
bptjm-46	129	12	observed	observe	VERB
bptjm-46	129	13	in	in	ADP
bptjm-46	129	14	normal	normal	ADJ
bptjm-46	129	15	mcf-10a	mcf-10a	ADJ
bptjm-46	129	16	human	human	ADJ
bptjm-46	129	17	mammary	mammary	ADJ
bptjm-46	129	18	epithelial	epithelial	ADJ
bptjm-46	129	19	cells	cell	NOUN
bptjm-46	129	20	.	.	PUNCT
bptjm-46	130	1	disrupting	disrupt	VERB
bptjm-46	130	2	mct4	mct4	NOUN
bptjm-46	130	3	function	function	NOUN
bptjm-46	130	4	leads	lead	VERB
bptjm-46	130	5	to	to	ADP
bptjm-46	130	6	an	an	DET
bptjm-46	130	7	accumulation	accumulation	NOUN
bptjm-46	130	8	of	of	ADP
bptjm-46	130	9	intracellular	intracellular	ADJ
bptjm-46	130	10	lactate	lactate	NOUN
bptjm-46	130	11	and	and	CCONJ
bptjm-46	130	12	a	a	DET
bptjm-46	130	13	decrease	decrease	NOUN
bptjm-46	130	14	in	in	ADP
bptjm-46	130	15	intracellular	intracellular	ADJ
bptjm-46	130	16	ph	ph	NOUN
bptjm-46	130	17	which	which	PRON
bptjm-46	130	18	may	may	AUX
bptjm-46	130	19	rapidly	rapidly	ADV
bptjm-46	130	20	damage	damage	VERB
bptjm-46	130	21	a	a	DET
bptjm-46	130	22	cell	cell	NOUN
bptjm-46	130	23	thereby	thereby	ADV
bptjm-46	130	24	inducing	induce	VERB
bptjm-46	130	25	necrosis	necrosis	NOUN
bptjm-46	130	26	,	,	PUNCT
bptjm-46	130	27	apoptosis	apoptosis	NOUN
bptjm-46	130	28	or	or	CCONJ
bptjm-46	130	29	growth	growth	NOUN
bptjm-46	130	30	arrest	arrest	NOUN
bptjm-46	130	31	.	.	PUNCT
bptjm-46	131	1	metformin	metformin	NOUN
bptjm-46	131	2	increases	increase	VERB
bptjm-46	131	3	glycolysis	glycolysis	NOUN
bptjm-46	131	4	thereby	thereby	ADV
bptjm-46	131	5	increasing	increase	VERB
bptjm-46	131	6	the	the	DET
bptjm-46	131	7	buildup	buildup	NOUN
bptjm-46	131	8	of	of	ADP
bptjm-46	131	9	intracellular	intracellular	ADJ
bptjm-46	131	10	lactate	lactate	NOUN
bptjm-46	131	11	,	,	PUNCT
bptjm-46	131	12	thereby	thereby	ADV
bptjm-46	131	13	accelerating	accelerate	VERB
bptjm-46	131	14	the	the	DET
bptjm-46	131	15	e	e	NOUN
bptjm-46	131	16	�	�	NOUN
bptjm-46	131	17	ects	ect	NOUN
bptjm-46	131	18	of	of	ADP
bptjm-46	131	19	the	the	DET
bptjm-46	131	20	mct4	mct4	PROPN
bptjm-46	131	21	inhibitor	inhibitor	NOUN
bptjm-46	131	22	.	.	PUNCT
bptjm-46	132	1	this	this	PRON
bptjm-46	132	2	can	can	AUX
bptjm-46	132	3	be	be	AUX
bptjm-46	132	4	used	use	VERB
bptjm-46	132	5	to	to	PART
bptjm-46	132	6	treat	treat	VERB
bptjm-46	132	7	high	high	ADJ
bptjm-46	132	8	glycolytic	glycolytic	ADJ
bptjm-46	132	9	rate	rate	NOUN
bptjm-46	132	10	/	/	SYM
bptjm-46	132	11	mct4	mct4	NOUN
bptjm-46	132	12	-	-	PUNCT
bptjm-46	132	13	expressing	express	VERB
bptjm-46	132	14	malignancies	malignancy	NOUN
bptjm-46	132	15	.	.	PUNCT
bptjm-46	133	1	another	another	DET
bptjm-46	133	2	possible	possible	ADJ
bptjm-46	133	3	combination	combination	NOUN
bptjm-46	133	4	is	be	AUX
bptjm-46	133	5	the	the	DET
bptjm-46	133	6	mct4	mct4	PROPN
bptjm-46	133	7	inhibitor	inhibitor	NOUN
bptjm-46	133	8	cb-2	cb-2	ADP
bptjm-46	133	9	and	and	CCONJ
bptjm-46	133	10	a	a	DET
bptjm-46	133	11	gls1	gls1	ADJ
bptjm-46	133	12	inhibitor	inhibitor	NOUN
bptjm-46	133	13	cb-839	cb-839	NOUN
bptjm-46	133	14	to	to	PART
bptjm-46	133	15	reengineer	reengineer	VERB
bptjm-46	133	16	cancer	cancer	NOUN
bptjm-46	133	17	metabolism40	metabolism40	NOUN
bptjm-46	133	18	.	.	PUNCT
bptjm-46	134	1	this	this	DET
bptjm-46	134	2	combination	combination	NOUN
bptjm-46	134	3	solves	solve	VERB
bptjm-46	134	4	berkeley	berkeley	PROPN
bptjm-46	134	5	pharma	pharma	PROPN
bptjm-46	134	6	tech	tech	NOUN
bptjm-46	134	7	journal	journal	NOUN
bptjm-46	134	8	of	of	ADP
bptjm-46	134	9	medicine	medicine	NOUN
bptjm-46	134	10	|	|	ADV
bptjm-46	134	11	110	110	NUM
bptjm-46	134	12	the	the	DET
bptjm-46	134	13	problem	problem	NOUN
bptjm-46	134	14	of	of	ADP
bptjm-46	134	15	increasing	increase	VERB
bptjm-46	134	16	ammonia	ammonia	ADJ
bptjm-46	134	17	production	production	NOUN
bptjm-46	134	18	to	to	PART
bptjm-46	134	19	neutralize	neutralize	VERB
bptjm-46	134	20	lactate	lactate	NOUN
bptjm-46	134	21	via	via	ADP
bptjm-46	134	22	restricting	restrict	VERB
bptjm-46	134	23	the	the	DET
bptjm-46	134	24	metabolic	metabolic	PROPN
bptjm-46	134	25	�	�	NOUN
bptjm-46	134	26	exibility	exibility	NOUN
bptjm-46	134	27	of	of	ADP
bptjm-46	134	28	these	these	DET
bptjm-46	134	29	cancer	cancer	NOUN
bptjm-46	134	30	cells	cell	NOUN
bptjm-46	134	31	.	.	PUNCT
bptjm-46	135	1	6	6	X
bptjm-46	135	2	.	.	X
bptjm-46	135	3	metformin	metformin	NOUN
bptjm-46	135	4	to	to	PART
bptjm-46	135	5	target	target	VERB
bptjm-46	135	6	cancer	cancer	NOUN
bptjm-46	135	7	cells	cell	NOUN
bptjm-46	135	8	’	'	PUNCT
bptjm-46	135	9	glucose	glucose	NOUN
bptjm-46	135	10	metabolism	metabolism	NOUN
bptjm-46	135	11	and	and	CCONJ
bptjm-46	135	12	mtor	mtor	NOUN
bptjm-46	135	13	pathway	pathway	NOUN
bptjm-46	135	14	the	the	DET
bptjm-46	135	15	collection	collection	NOUN
bptjm-46	135	16	of	of	ADP
bptjm-46	135	17	genetic	genetic	ADJ
bptjm-46	135	18	alterations	alteration	NOUN
bptjm-46	135	19	in	in	ADP
bptjm-46	135	20	cancer	cancer	NOUN
bptjm-46	135	21	cells	cell	NOUN
bptjm-46	135	22	causes	cause	VERB
bptjm-46	135	23	interference	interference	NOUN
bptjm-46	135	24	with	with	ADP
bptjm-46	135	25	the	the	DET
bptjm-46	135	26	regular	regular	ADJ
bptjm-46	135	27	cellular	cellular	ADJ
bptjm-46	135	28	signaling	signal	VERB
bptjm-46	135	29	pathways	pathway	NOUN
bptjm-46	135	30	,	,	PUNCT
bptjm-46	135	31	this	this	PRON
bptjm-46	135	32	then	then	ADV
bptjm-46	135	33	leads	lead	VERB
bptjm-46	135	34	to	to	ADP
bptjm-46	135	35	cell	cell	NOUN
bptjm-46	135	36	growth	growth	NOUN
bptjm-46	135	37	for	for	ADP
bptjm-46	135	38	cancer	cancer	NOUN
bptjm-46	135	39	.	.	PUNCT
bptjm-46	136	1	despite	despite	SCONJ
bptjm-46	136	2	the	the	DET
bptjm-46	136	3	di	di	PROPN
bptjm-46	136	4	�	�	PROPN
bptjm-46	136	5	erent	erent	NOUN
bptjm-46	136	6	current	current	ADJ
bptjm-46	136	7	treatment	treatment	NOUN
bptjm-46	136	8	plans	plan	NOUN
bptjm-46	136	9	that	that	PRON
bptjm-46	136	10	are	be	AUX
bptjm-46	136	11	o	o	NOUN
bptjm-46	136	12	�	�	X
bptjm-46	136	13	ered	ere	VERB
bptjm-46	136	14	,	,	PUNCT
bptjm-46	136	15	many	many	ADJ
bptjm-46	136	16	recoveries	recovery	NOUN
bptjm-46	136	17	fail	fail	VERB
bptjm-46	136	18	due	due	ADP
bptjm-46	136	19	to	to	ADP
bptjm-46	136	20	the	the	DET
bptjm-46	136	21	drug	drug	NOUN
bptjm-46	136	22	resistance	resistance	NOUN
bptjm-46	136	23	and	and	CCONJ
bptjm-46	136	24	its	its	PRON
bptjm-46	136	25	adverse	adverse	ADJ
bptjm-46	136	26	side	side	NOUN
bptjm-46	136	27	e	e	NOUN
bptjm-46	136	28	�	�	NOUN
bptjm-46	136	29	ects	ect	NOUN
bptjm-46	136	30	.	.	PUNCT
bptjm-46	137	1	though	though	SCONJ
bptjm-46	137	2	in	in	ADP
bptjm-46	137	3	recent	recent	ADJ
bptjm-46	137	4	studies	study	NOUN
bptjm-46	137	5	,	,	PUNCT
bptjm-46	137	6	metabolic	metabolic	NOUN
bptjm-46	137	7	reprogramming	reprogramming	NOUN
bptjm-46	137	8	has	have	AUX
bptjm-46	137	9	served	serve	VERB
bptjm-46	137	10	as	as	ADP
bptjm-46	137	11	a	a	DET
bptjm-46	137	12	possible	possible	ADJ
bptjm-46	137	13	cancer	cancer	NOUN
bptjm-46	137	14	therapy	therapy	NOUN
bptjm-46	137	15	.	.	PUNCT
bptjm-46	138	1	with	with	ADP
bptjm-46	138	2	this	this	PRON
bptjm-46	138	3	,	,	PUNCT
bptjm-46	138	4	we	we	PRON
bptjm-46	138	5	want	want	VERB
bptjm-46	138	6	to	to	PART
bptjm-46	138	7	identify	identify	VERB
bptjm-46	138	8	the	the	DET
bptjm-46	138	9	glucose	glucose	NOUN
bptjm-46	138	10	metabolism	metabolism	NOUN
bptjm-46	138	11	of	of	ADP
bptjm-46	138	12	cancer	cancer	NOUN
bptjm-46	138	13	cells	cell	NOUN
bptjm-46	138	14	to	to	PART
bptjm-46	138	15	alter	alter	VERB
bptjm-46	138	16	so	so	SCONJ
bptjm-46	138	17	it	it	PRON
bptjm-46	138	18	causes	cause	VERB
bptjm-46	138	19	glucose	glucose	NOUN
bptjm-46	138	20	-	-	PUNCT
bptjm-46	138	21	lowering	lower	VERB
bptjm-46	138	22	agents	agent	NOUN
bptjm-46	138	23	like	like	ADP
bptjm-46	138	24	metformin	metformin	NOUN
bptjm-46	138	25	to	to	PART
bptjm-46	138	26	be	be	AUX
bptjm-46	138	27	a	a	DET
bptjm-46	138	28	possible	possible	ADJ
bptjm-46	138	29	treatment	treatment	NOUN
bptjm-46	138	30	in	in	ADP
bptjm-46	138	31	cancer	cancer	NOUN
bptjm-46	138	32	cells	cell	NOUN
bptjm-46	138	33	.	.	PUNCT
bptjm-46	139	1	one	one	NUM
bptjm-46	139	2	change	change	NOUN
bptjm-46	139	3	we	we	PRON
bptjm-46	139	4	can	can	AUX
bptjm-46	139	5	see	see	VERB
bptjm-46	139	6	in	in	ADP
bptjm-46	139	7	cancer	cancer	NOUN
bptjm-46	139	8	metabolism	metabolism	NOUN
bptjm-46	139	9	is	be	AUX
bptjm-46	139	10	known	know	VERB
bptjm-46	139	11	as	as	ADP
bptjm-46	139	12	the	the	DET
bptjm-46	139	13	warburg	warburg	PROPN
bptjm-46	139	14	e	e	NOUN
bptjm-46	139	15	�	�	PROPN
bptjm-46	139	16	ect	ect	VERB
bptjm-46	139	17	.	.	PUNCT
bptjm-46	140	1	the	the	DET
bptjm-46	140	2	metabolic	metabolic	NOUN
bptjm-46	140	3	adaptation	adaptation	NOUN
bptjm-46	140	4	shifts	shift	NOUN
bptjm-46	140	5	their	their	PRON
bptjm-46	140	6	energy	energy	NOUN
bptjm-46	140	7	production	production	NOUN
bptjm-46	140	8	from	from	ADP
bptjm-46	140	9	oxidative	oxidative	ADJ
bptjm-46	140	10	phosphorylation	phosphorylation	NOUN
bptjm-46	140	11	in	in	ADP
bptjm-46	140	12	the	the	DET
bptjm-46	140	13	process	process	NOUN
bptjm-46	140	14	of	of	ADP
bptjm-46	140	15	aerobic	aerobic	ADJ
bptjm-46	140	16	glycolysis	glycolysis	NOUN
bptjm-46	140	17	.	.	PUNCT
bptjm-46	141	1	metformin	metformin	NOUN
bptjm-46	141	2	is	be	AUX
bptjm-46	141	3	a	a	DET
bptjm-46	141	4	commonly	commonly	ADV
bptjm-46	141	5	prescribed	prescribe	VERB
bptjm-46	141	6	drug	drug	NOUN
bptjm-46	141	7	used	use	VERB
bptjm-46	141	8	for	for	ADP
bptjm-46	141	9	type	type	NOUN
bptjm-46	141	10	2	2	NUM
bptjm-46	141	11	diabetes	diabete	NOUN
bptjm-46	141	12	,	,	PUNCT
bptjm-46	141	13	which	which	PRON
bptjm-46	141	14	also	also	ADV
bptjm-46	141	15	displays	display	VERB
bptjm-46	141	16	anticancer	anticancer	NOUN
bptjm-46	141	17	properties	property	NOUN
bptjm-46	141	18	in	in	ADP
bptjm-46	141	19	inhibiting	inhibit	VERB
bptjm-46	141	20	mitochondrial	mitochondrial	ADJ
bptjm-46	141	21	complex	complex	ADJ
bptjm-46	141	22	i,41,42	i,41,42	NOUN
bptjm-46	141	23	activating	activate	VERB
bptjm-46	141	24	ampk	ampk	NOUN
bptjm-46	141	25	,	,	PUNCT
bptjm-46	141	26	a	a	DET
bptjm-46	141	27	regulator	regulator	NOUN
bptjm-46	141	28	for	for	ADP
bptjm-46	141	29	energy	energy	NOUN
bptjm-46	141	30	metabolism	metabolism	NOUN
bptjm-46	141	31	,	,	PUNCT
bptjm-46	141	32	and	and	CCONJ
bptjm-46	141	33	reducing	reduce	VERB
bptjm-46	141	34	insulin	insulin	NOUN
bptjm-46	141	35	and	and	CCONJ
bptjm-46	141	36	insulin	insulin	NOUN
bptjm-46	141	37	-	-	PUNCT
bptjm-46	141	38	like	like	ADJ
bptjm-46	141	39	growth	growth	NOUN
bptjm-46	141	40	factor	factor	NOUN
bptjm-46	141	41	1	1	NUM
bptjm-46	141	42	(	(	PUNCT
bptjm-46	141	43	igf-1	igf-1	NOUN
bptjm-46	141	44	)	)	PUNCT
bptjm-46	141	45	,	,	PUNCT
bptjm-46	141	46	which	which	PRON
bptjm-46	141	47	performs	perform	VERB
bptjm-46	141	48	anti	anti	ADJ
bptjm-46	141	49	-	-	ADJ
bptjm-46	141	50	tumor	tumor	ADJ
bptjm-46	141	51	functions	function	NOUN
bptjm-46	141	52	.	.	PUNCT
bptjm-46	142	1	in	in	ADP
bptjm-46	142	2	addition	addition	NOUN
bptjm-46	142	3	,	,	PUNCT
bptjm-46	142	4	metformin	metformin	NOUN
bptjm-46	142	5	has	have	AUX
bptjm-46	142	6	shown	show	VERB
bptjm-46	142	7	ability	ability	NOUN
bptjm-46	142	8	to	to	PART
bptjm-46	142	9	inhibit	inhibit	VERB
bptjm-46	142	10	the	the	DET
bptjm-46	142	11	mtor	mtor	PROPN
bptjm-46	142	12	pathway	pathway	NOUN
bptjm-46	142	13	,	,	PUNCT
bptjm-46	142	14	which	which	PRON
bptjm-46	142	15	is	be	AUX
bptjm-46	142	16	involved	involve	VERB
bptjm-46	142	17	in	in	ADP
bptjm-46	142	18	the	the	DET
bptjm-46	142	19	protein	protein	NOUN
bptjm-46	142	20	synthesis	synthesis	NOUN
bptjm-46	142	21	and	and	CCONJ
bptjm-46	142	22	cell	cell	NOUN
bptjm-46	142	23	growth	growth	NOUN
bptjm-46	142	24	process	process	NOUN
bptjm-46	142	25	.	.	PUNCT
bptjm-46	143	1	there	there	PRON
bptjm-46	143	2	are	be	VERB
bptjm-46	143	3	two	two	NUM
bptjm-46	143	4	types	type	NOUN
bptjm-46	143	5	of	of	ADP
bptjm-46	143	6	forms	form	NOUN
bptjm-46	143	7	of	of	ADP
bptjm-46	143	8	mtor	mtor	NOUN
bptjm-46	143	9	:	:	PUNCT
bptjm-46	143	10	complex	complex	ADJ
bptjm-46	143	11	1	1	NUM
bptjm-46	143	12	(	(	PUNCT
bptjm-46	143	13	mtorc1	mtorc1	NOUN
bptjm-46	143	14	)	)	PUNCT
bptjm-46	143	15	used	use	VERB
bptjm-46	143	16	in	in	ADP
bptjm-46	143	17	growth	growth	NOUN
bptjm-46	143	18	factors	factor	NOUN
bptjm-46	143	19	,	,	PUNCT
bptjm-46	143	20	glucose	glucose	NOUN
bptjm-46	143	21	,	,	PUNCT
bptjm-46	143	22	and	and	CCONJ
bptjm-46	143	23	helps	help	VERB
bptjm-46	143	24	with	with	ADP
bptjm-46	143	25	protein	protein	NOUN
bptjm-46	143	26	synthesis	synthesis	NOUN
bptjm-46	143	27	;	;	PUNCT
bptjm-46	143	28	and	and	CCONJ
bptjm-46	143	29	complex	complex	ADJ
bptjm-46	143	30	2	2	NUM
bptjm-46	143	31	(	(	PUNCT
bptjm-46	143	32	mtorc1	mtorc1	NOUN
bptjm-46	143	33	)	)	PUNCT
bptjm-46	143	34	used	use	VERB
bptjm-46	143	35	for	for	ADP
bptjm-46	143	36	regulating	regulate	VERB
bptjm-46	143	37	cell	cell	NOUN
bptjm-46	143	38	survival	survival	NOUN
bptjm-46	143	39	and	and	CCONJ
bptjm-46	143	40	metabolism43	metabolism43	ADV
bptjm-46	143	41	.	.	PUNCT
bptjm-46	144	1	metformin	metformin	NOUN
bptjm-46	144	2	inhibits	inhibit	VERB
bptjm-46	144	3	mtorc1	mtorc1	NOUN
bptjm-46	144	4	which	which	PRON
bptjm-46	144	5	then	then	ADV
bptjm-46	144	6	activates	activate	VERB
bptjm-46	144	7	ampk	ampk	NOUN
bptjm-46	144	8	and	and	CCONJ
bptjm-46	144	9	phosphorylates	phosphorylate	VERB
bptjm-46	144	10	the	the	DET
bptjm-46	144	11	tsc2	tsc2	PROPN
bptjm-46	144	12	protein	protein	NOUN
bptjm-46	144	13	,	,	PUNCT
bptjm-46	144	14	the	the	DET
bptjm-46	144	15	negative	negative	ADJ
bptjm-46	144	16	regulator	regulator	NOUN
bptjm-46	144	17	of	of	ADP
bptjm-46	144	18	mtoc1	mtoc1	PROPN
bptjm-46	144	19	.	.	PUNCT
bptjm-46	145	1	this	this	DET
bptjm-46	145	2	inhibition	inhibition	NOUN
bptjm-46	145	3	can	can	AUX
bptjm-46	145	4	occur	occur	VERB
bptjm-46	145	5	both	both	CCONJ
bptjm-46	145	6	dependent	dependent	ADJ
bptjm-46	145	7	and	and	CCONJ
bptjm-46	145	8	independent	independent	ADJ
bptjm-46	145	9	of	of	ADP
bptjm-46	145	10	amp	amp	PROPN
bptjm-46	145	11	-	-	PUNCT
bptjm-46	145	12	activated	activate	VERB
bptjm-46	145	13	protein	protein	NOUN
bptjm-46	145	14	kinase	kinase	NOUN
bptjm-46	145	15	(	(	PUNCT
bptjm-46	145	16	ampk	ampk	NOUN
bptjm-46	145	17	)	)	PUNCT
bptjm-46	145	18	activation	activation	NOUN
bptjm-46	145	19	,	,	PUNCT
bptjm-46	145	20	leading	lead	VERB
bptjm-46	145	21	to	to	ADP
bptjm-46	145	22	the	the	DET
bptjm-46	145	23	decrease	decrease	NOUN
bptjm-46	145	24	in	in	ADP
bptjm-46	145	25	protein	protein	NOUN
bptjm-46	145	26	synthesis	synthesis	NOUN
bptjm-46	145	27	and	and	CCONJ
bptjm-46	145	28	cell	cell	NOUN
bptjm-46	145	29	growth	growth	NOUN
bptjm-46	145	30	.	.	PUNCT
bptjm-46	146	1	metformin	metformin	NOUN
bptjm-46	146	2	is	be	AUX
bptjm-46	146	3	able	able	ADJ
bptjm-46	146	4	to	to	PART
bptjm-46	146	5	inhibit	inhibit	VERB
bptjm-46	146	6	mtorc1	mtorc1	NOUN
bptjm-46	146	7	independently	independently	ADV
bptjm-46	146	8	when	when	SCONJ
bptjm-46	146	9	ampk	ampk	NOUN
bptjm-46	146	10	is	be	AUX
bptjm-46	146	11	activated	activate	VERB
bptjm-46	146	12	as	as	SCONJ
bptjm-46	146	13	it	it	PRON
bptjm-46	146	14	is	be	AUX
bptjm-46	146	15	binding	bind	VERB
bptjm-46	146	16	to	to	ADP
bptjm-46	146	17	the	the	DET
bptjm-46	146	18	complex.43	complex.43	NOUN
bptjm-46	146	19	this	this	DET
bptjm-46	146	20	dual	dual	ADJ
bptjm-46	146	21	mechanism	mechanism	NOUN
bptjm-46	146	22	causes	cause	VERB
bptjm-46	146	23	a	a	DET
bptjm-46	146	24	positive	positive	ADJ
bptjm-46	146	25	treatment	treatment	NOUN
bptjm-46	146	26	for	for	ADP
bptjm-46	146	27	the	the	DET
bptjm-46	146	28	host	host	NOUN
bptjm-46	146	29	,	,	PUNCT
bptjm-46	146	30	since	since	SCONJ
bptjm-46	146	31	metformin	metformin	NOUN
bptjm-46	146	32	has	have	VERB
bptjm-46	146	33	multiple	multiple	ADJ
bptjm-46	146	34	strategies	strategy	NOUN
bptjm-46	146	35	to	to	PART
bptjm-46	146	36	repress	repress	VERB
bptjm-46	146	37	pathways	pathway	NOUN
bptjm-46	146	38	critical	critical	ADJ
bptjm-46	146	39	for	for	ADP
bptjm-46	146	40	cancer	cancer	NOUN
bptjm-46	146	41	cell	cell	NOUN
bptjm-46	146	42	growth	growth	NOUN
bptjm-46	146	43	.	.	PUNCT
bptjm-46	147	1	berkeley	berkeley	PROPN
bptjm-46	147	2	pharma	pharma	PROPN
bptjm-46	147	3	tech	tech	PROPN
bptjm-46	147	4	journal	journal	NOUN
bptjm-46	147	5	of	of	ADP
bptjm-46	147	6	medicine	medicine	NOUN
bptjm-46	147	7	|	|	ADV
bptjm-46	147	8	111	111	NUM
bptjm-46	147	9	recent	recent	ADJ
bptjm-46	147	10	studies	study	NOUN
bptjm-46	147	11	with	with	ADP
bptjm-46	147	12	mice	mouse	NOUN
bptjm-46	147	13	given	give	VERB
bptjm-46	147	14	metformin	metformin	NOUN
bptjm-46	147	15	after	after	ADP
bptjm-46	147	16	being	be	AUX
bptjm-46	147	17	exposed	expose	VERB
bptjm-46	147	18	to	to	ADP
bptjm-46	147	19	carcinogen	carcinogen	PROPN
bptjm-46	147	20	show	show	VERB
bptjm-46	147	21	a	a	DET
bptjm-46	147	22	reduction	reduction	NOUN
bptjm-46	147	23	of	of	ADP
bptjm-46	147	24	lung	lung	NOUN
bptjm-46	147	25	tumor	tumor	NOUN
bptjm-46	147	26	burden	burden	NOUN
bptjm-46	147	27	by	by	ADP
bptjm-46	147	28	up	up	ADP
bptjm-46	147	29	to	to	PART
bptjm-46	147	30	53	53	NUM
bptjm-46	147	31	%	%	NOUN
bptjm-46	147	32	.	.	PUNCT
bptjm-46	148	1	however	however	ADV
bptjm-46	148	2	,	,	PUNCT
bptjm-46	148	3	only	only	ADV
bptjm-46	148	4	modest	modest	ADJ
bptjm-46	148	5	e	e	NOUN
bptjm-46	148	6	�	�	NOUN
bptjm-46	148	7	ects	ect	NOUN
bptjm-46	148	8	presented	present	VERB
bptjm-46	148	9	as	as	ADP
bptjm-46	148	10	mtor	mtor	PROPN
bptjm-46	148	11	was	be	AUX
bptjm-46	148	12	inhibited	inhibit	VERB
bptjm-46	148	13	in	in	ADP
bptjm-46	148	14	lung	lung	NOUN
bptjm-46	148	15	tumors	tumor	NOUN
bptjm-46	148	16	45	45	NUM
bptjm-46	148	17	.	.	PUNCT
bptjm-46	149	1	the	the	DET
bptjm-46	149	2	researchers	researcher	NOUN
bptjm-46	149	3	then	then	ADV
bptjm-46	149	4	inject	inject	VERB
bptjm-46	149	5	mice	mouse	NOUN
bptjm-46	149	6	with	with	ADP
bptjm-46	149	7	metformin	metformin	NOUN
bptjm-46	149	8	to	to	PART
bptjm-46	149	9	assess	assess	VERB
bptjm-46	149	10	whether	whether	SCONJ
bptjm-46	149	11	this	this	DET
bptjm-46	149	12	method	method	NOUN
bptjm-46	149	13	would	would	AUX
bptjm-46	149	14	improve	improve	VERB
bptjm-46	149	15	mtor	mtor	NOUN
bptjm-46	149	16	inhibition	inhibition	NOUN
bptjm-46	149	17	.	.	PUNCT
bptjm-46	150	1	the	the	DET
bptjm-46	150	2	result	result	NOUN
bptjm-46	150	3	shows	show	VERB
bptjm-46	150	4	that	that	SCONJ
bptjm-46	150	5	plasma	plasma	NOUN
bptjm-46	150	6	levels	level	NOUN
bptjm-46	150	7	of	of	ADP
bptjm-46	150	8	metformin	metformin	NOUN
bptjm-46	150	9	were	be	AUX
bptjm-46	150	10	higher	high	ADJ
bptjm-46	150	11	after	after	ADP
bptjm-46	150	12	injection	injection	NOUN
bptjm-46	150	13	than	than	ADP
bptjm-46	150	14	oral	oral	ADJ
bptjm-46	150	15	administration	administration	NOUN
bptjm-46	150	16	.	.	PUNCT
bptjm-46	151	1	on	on	ADP
bptjm-46	151	2	the	the	DET
bptjm-46	151	3	other	other	ADJ
bptjm-46	151	4	hand	hand	NOUN
bptjm-46	151	5	,	,	PUNCT
bptjm-46	151	6	metformin	metformin	NOUN
bptjm-46	151	7	also	also	ADV
bptjm-46	151	8	activates	activate	VERB
bptjm-46	151	9	ampk	ampk	NOUN
bptjm-46	151	10	and	and	CCONJ
bptjm-46	151	11	inhibits	inhibit	VERB
bptjm-46	151	12	mtor	mtor	NOUN
bptjm-46	151	13	in	in	ADP
bptjm-46	151	14	liver	liver	NOUN
bptjm-46	151	15	tissue	tissue	NOUN
bptjm-46	151	16	,	,	PUNCT
bptjm-46	151	17	but	but	CCONJ
bptjm-46	151	18	it	it	PRON
bptjm-46	151	19	only	only	ADV
bptjm-46	151	20	inhibits	inhibit	VERB
bptjm-46	151	21	phosphorylation	phosphorylation	NOUN
bptjm-46	151	22	process	process	NOUN
bptjm-46	151	23	of	of	ADP
bptjm-46	151	24	igf	igf	PROPN
bptjm-46	151	25	-	-	PROPN
bptjm-46	151	26	ir	ir	PROPN
bptjm-46	151	27	/	/	SYM
bptjm-46	151	28	ir	ir	PROPN
bptjm-46	151	29	,	,	PUNCT
bptjm-46	151	30	akt	akt	PROPN
bptjm-46	151	31	,	,	PUNCT
bptjm-46	151	32	erk	erk	PROPN
bptjm-46	151	33	,	,	PUNCT
bptjm-46	151	34	and	and	CCONJ
bptjm-46	151	35	mtor	mtor	PROPN
bptjm-46	151	36	in	in	ADP
bptjm-46	151	37	lung	lung	NOUN
bptjm-46	151	38	tissue	tissue	NOUN
bptjm-46	151	39	.	.	PUNCT
bptjm-46	152	1	this	this	PRON
bptjm-46	152	2	suggests	suggest	VERB
bptjm-46	152	3	that	that	SCONJ
bptjm-46	152	4	metformin	metformin	NOUN
bptjm-46	152	5	indirectly	indirectly	ADV
bptjm-46	152	6	inhibited	inhibit	VERB
bptjm-46	152	7	mtor	mtor	NOUN
bptjm-46	152	8	in	in	ADP
bptjm-46	152	9	lung	lung	NOUN
bptjm-46	152	10	tissue	tissue	NOUN
bptjm-46	152	11	by	by	ADP
bptjm-46	152	12	decreasing	decrease	VERB
bptjm-46	152	13	activation	activation	NOUN
bptjm-46	152	14	of	of	ADP
bptjm-46	152	15	igf-1r	igf-1r	PROPN
bptjm-46	152	16	/	/	SYM
bptjm-46	152	17	ir	ir	PROPN
bptjm-46	152	18	and	and	CCONJ
bptjm-46	152	19	akt	akt	PROPN
bptjm-46	152	20	upstream	upstream	NOUN
bptjm-46	152	21	of	of	ADP
bptjm-46	152	22	mtor45	mtor45	PROPN
bptjm-46	152	23	.	.	PUNCT
bptjm-46	153	1	a	a	DET
bptjm-46	153	2	follow	follow	VERB
bptjm-46	153	3	-	-	PUNCT
bptjm-46	153	4	up	up	ADP
bptjm-46	153	5	study	study	NOUN
bptjm-46	153	6	showed	show	VERB
bptjm-46	153	7	that	that	SCONJ
bptjm-46	153	8	intraperitoneal	intraperitoneal	ADJ
bptjm-46	153	9	administration	administration	NOUN
bptjm-46	153	10	of	of	ADP
bptjm-46	153	11	metformin	metformin	PROPN
bptjm-46	153	12	decreased	decrease	VERB
bptjm-46	153	13	tumor	tumor	NOUN
bptjm-46	153	14	burden	burden	NOUN
bptjm-46	153	15	by	by	ADP
bptjm-46	153	16	72	72	NUM
bptjm-46	153	17	%	%	NOUN
bptjm-46	153	18	,	,	PUNCT
bptjm-46	153	19	which	which	PRON
bptjm-46	153	20	correlates	correlate	VERB
bptjm-46	153	21	with	with	ADP
bptjm-46	153	22	decreased	decrease	VERB
bptjm-46	153	23	cellular	cellular	ADJ
bptjm-46	153	24	proliferation	proliferation	NOUN
bptjm-46	153	25	and	and	CCONJ
bptjm-46	153	26	marked	mark	VERB
bptjm-46	153	27	inhibition	inhibition	NOUN
bptjm-46	153	28	of	of	ADP
bptjm-46	153	29	mtor	mtor	NOUN
bptjm-46	153	30	in	in	ADP
bptjm-46	153	31	tumors	tumor	NOUN
bptjm-46	153	32	,	,	PUNCT
bptjm-46	153	33	as	as	SCONJ
bptjm-46	153	34	shown	show	VERB
bptjm-46	153	35	in	in	ADP
bptjm-46	153	36	�	�	PROPN
bptjm-46	153	37	gure	gure	NOUN
bptjm-46	153	38	2	2	NUM
bptjm-46	153	39	.	.	PUNCT
bptjm-46	153	40	figure	figure	NOUN
bptjm-46	153	41	2	2	NUM
bptjm-46	153	42	.	.	PUNCT
bptjm-46	153	43	as	as	SCONJ
bptjm-46	153	44	the	the	DET
bptjm-46	153	45	intake	intake	ADJ
bptjm-46	153	46	ofmetformin	ofmetformin	NOUN
bptjm-46	153	47	treatment	treatment	NOUN
bptjm-46	153	48	inhibits	inhibit	VERB
bptjm-46	153	49	plasma	plasma	NOUN
bptjm-46	153	50	igf-1	igf-1	NOUN
bptjm-46	153	51	level	level	NOUN
bptjm-46	153	52	in	in	ADP
bptjm-46	153	53	all	all	DET
bptjm-46	153	54	tissues	tissue	NOUN
bptjm-46	153	55	.	.	PUNCT
bptjm-46	154	1	as	as	SCONJ
bptjm-46	154	2	mentioned	mention	VERB
bptjm-46	154	3	,	,	PUNCT
bptjm-46	154	4	themetformin	themetformin	NOUN
bptjm-46	154	5	inhibition	inhibition	NOUN
bptjm-46	154	6	also	also	ADV
bptjm-46	154	7	has	have	VERB
bptjm-46	154	8	specificity	specificity	NOUN
bptjm-46	154	9	in	in	ADP
bptjm-46	154	10	lung	lung	NOUN
bptjm-46	154	11	and	and	CCONJ
bptjm-46	154	12	liver	liver	NOUN
bptjm-46	154	13	tissue	tissue	NOUN
bptjm-46	154	14	.	.	PUNCT
bptjm-46	155	1	metformin	metformin	NOUN
bptjm-46	155	2	swords	sword	NOUN
bptjm-46	155	3	decrease	decrease	VERB
bptjm-46	155	4	with	with	ADP
bptjm-46	155	5	the	the	DET
bptjm-46	155	6	phosphorylation	phosphorylation	NOUN
bptjm-46	155	7	of	of	ADP
bptjm-46	155	8	igf-1	igf-1	ADJ
bptjm-46	155	9	and	and	CCONJ
bptjm-46	155	10	the	the	DET
bptjm-46	155	11	insulin	insulin	NOUN
bptjm-46	155	12	receptors	receptor	NOUN
bptjm-46	155	13	in	in	ADP
bptjm-46	155	14	lung	lung	NOUN
bptjm-46	155	15	tissues	tissue	NOUN
bptjm-46	155	16	.	.	PUNCT
bptjm-46	156	1	the	the	DET
bptjm-46	156	2	drug	drug	NOUN
bptjm-46	156	3	is	be	AUX
bptjm-46	156	4	known	know	VERB
bptjm-46	156	5	for	for	ADP
bptjm-46	156	6	reducing	reduce	VERB
bptjm-46	156	7	the	the	DET
bptjm-46	156	8	levels	level	NOUN
bptjm-46	156	9	of	of	ADP
bptjm-46	156	10	hormones	hormone	NOUN
bptjm-46	156	11	presentation	presentation	NOUN
bptjm-46	156	12	in	in	ADP
bptjm-46	156	13	patients	patient	NOUN
bptjm-46	156	14	.	.	PUNCT
bptjm-46	157	1	with	with	ADP
bptjm-46	157	2	oral	oral	ADJ
bptjm-46	157	3	administration	administration	NOUN
bptjm-46	157	4	of	of	ADP
bptjm-46	157	5	metformin	metformin	PROPN
bptjm-46	157	6	,	,	PUNCT
bptjm-46	157	7	study	study	NOUN
bptjm-46	157	8	shows	show	VERB
bptjm-46	157	9	a	a	DET
bptjm-46	157	10	decrease	decrease	NOUN
bptjm-46	157	11	of	of	ADP
bptjm-46	157	12	1	1	NUM
bptjm-46	157	13	or	or	CCONJ
bptjm-46	157	14	5	5	NUM
bptjm-46	157	15	mg	mg	NUM
bptjm-46	157	16	/	/	SYM
bptjm-46	157	17	ml	ml	X
bptjm-46	157	18	of	of	ADP
bptjm-46	157	19	circulating	circulate	VERB
bptjm-46	157	20	igf-1	igf-1	NOUN
bptjm-46	157	21	by	by	ADP
bptjm-46	157	22	approximately	approximately	ADV
bptjm-46	157	23	20	20	NUM
bptjm-46	157	24	%	%	NOUN
bptjm-46	157	25	and	and	CCONJ
bptjm-46	157	26	the	the	DET
bptjm-46	157	27	insulin	insulin	NOUN
bptjm-46	157	28	by	by	ADP
bptjm-46	157	29	20	20	NUM
bptjm-46	157	30	%	%	NOUN
bptjm-46	157	31	and	and	CCONJ
bptjm-46	157	32	35%44	35%44	NUM
bptjm-46	157	33	.	.	PUNCT
bptjm-46	158	1	berkeley	berkeley	PROPN
bptjm-46	158	2	pharma	pharma	PROPN
bptjm-46	158	3	tech	tech	PROPN
bptjm-46	158	4	journal	journal	NOUN
bptjm-46	158	5	of	of	ADP
bptjm-46	158	6	medicine	medicine	NOUN
bptjm-46	158	7	|	|	ADV
bptjm-46	158	8	112	112	NUM
bptjm-46	158	9	there	there	PRON
bptjm-46	158	10	was	be	VERB
bptjm-46	158	11	an	an	DET
bptjm-46	158	12	injection	injection	NOUN
bptjm-46	158	13	of	of	ADP
bptjm-46	158	14	metformin	metformin	NOUN
bptjm-46	158	15	intraperitoneally	intraperitoneally	ADV
bptjm-46	158	16	to	to	PART
bptjm-46	158	17	assess	assess	VERB
bptjm-46	158	18	its	its	PRON
bptjm-46	158	19	inhibitory	inhibitory	ADJ
bptjm-46	158	20	e	e	NOUN
bptjm-46	158	21	�	�	NOUN
bptjm-46	158	22	ect	ect	VERB
bptjm-46	158	23	on	on	ADP
bptjm-46	158	24	mtor	mtor	PROPN
bptjm-46	158	25	pathway	pathway	NOUN
bptjm-46	158	26	.	.	PUNCT
bptjm-46	159	1	however	however	ADV
bptjm-46	159	2	,	,	PUNCT
bptjm-46	159	3	the	the	DET
bptjm-46	159	4	intraperitoneal	intraperitoneal	ADJ
bptjm-46	159	5	injection	injection	NOUN
bptjm-46	159	6	did	do	AUX
bptjm-46	159	7	not	not	PART
bptjm-46	159	8	decrease	decrease	VERB
bptjm-46	159	9	the	the	DET
bptjm-46	159	10	igf	igf	PROPN
bptjm-46	159	11	-	-	PROPN
bptjm-46	159	12	i	i	PROPN
bptjm-46	159	13	levels	level	NOUN
bptjm-46	159	14	signi	signi	VERB
bptjm-46	159	15	�	�	NOUN
bptjm-46	159	16	cantly	cantly	ADV
bptjm-46	159	17	.	.	PUNCT
bptjm-46	160	1	instead	instead	ADV
bptjm-46	160	2	,	,	PUNCT
bptjm-46	160	3	the	the	DET
bptjm-46	160	4	levels	level	NOUN
bptjm-46	160	5	of	of	ADP
bptjm-46	160	6	igf-1	igf-1	NOUN
bptjm-46	160	7	inside	inside	ADP
bptjm-46	160	8	the	the	DET
bptjm-46	160	9	mice	mice	NOUN
bptjm-46	160	10	shows	show	VERB
bptjm-46	160	11	a	a	DET
bptjm-46	160	12	signi	signi	ADJ
bptjm-46	160	13	�	�	NOUN
bptjm-46	160	14	cant	cant	NOUN
bptjm-46	160	15	reduction	reduction	NOUN
bptjm-46	160	16	from	from	ADP
bptjm-46	160	17	the	the	DET
bptjm-46	160	18	wild	wild	ADJ
bptjm-46	160	19	type	type	NOUN
bptjm-46	160	20	comparison	comparison	NOUN
bptjm-46	160	21	group	group	NOUN
bptjm-46	160	22	.	.	PUNCT
bptjm-46	161	1	this	this	PRON
bptjm-46	161	2	can	can	AUX
bptjm-46	161	3	indicate	indicate	VERB
bptjm-46	161	4	that	that	DET
bptjm-46	161	5	stress	stress	NOUN
bptjm-46	161	6	in	in	ADP
bptjm-46	161	7	daily	daily	ADJ
bptjm-46	161	8	injection	injection	NOUN
bptjm-46	161	9	can	can	AUX
bptjm-46	161	10	alter	alter	VERB
bptjm-46	161	11	the	the	DET
bptjm-46	161	12	masked	masked	ADJ
bptjm-46	161	13	inhibitory	inhibitory	NOUN
bptjm-46	161	14	e	e	NOUN
bptjm-46	161	15	�	�	NOUN
bptjm-46	161	16	ect	ect	VERB
bptjm-46	161	17	of	of	ADP
bptjm-46	161	18	metformin	metformin	NOUN
bptjm-46	161	19	in	in	ADP
bptjm-46	161	20	circulating	circulate	VERB
bptjm-46	161	21	the	the	DET
bptjm-46	161	22	levels	level	NOUN
bptjm-46	161	23	of	of	ADP
bptjm-46	161	24	igf-1	igf-1	NOUN
bptjm-46	161	25	.	.	PUNCT
bptjm-46	162	1	this	this	PRON
bptjm-46	162	2	supports	support	VERB
bptjm-46	162	3	the	the	DET
bptjm-46	162	4	hypothesis	hypothesis	NOUN
bptjm-46	162	5	that	that	PRON
bptjm-46	162	6	metformin	metformin	NOUN
bptjm-46	162	7	can	can	AUX
bptjm-46	162	8	be	be	AUX
bptjm-46	162	9	used	use	VERB
bptjm-46	162	10	in	in	ADP
bptjm-46	162	11	mtor	mtor	PROPN
bptjm-46	162	12	pathways	pathway	NOUN
bptjm-46	162	13	with	with	ADP
bptjm-46	162	14	cancer	cancer	NOUN
bptjm-46	162	15	patients	patient	NOUN
bptjm-46	162	16	,	,	PUNCT
bptjm-46	162	17	since	since	SCONJ
bptjm-46	162	18	it	it	PRON
bptjm-46	162	19	will	will	AUX
bptjm-46	162	20	decrease	decrease	VERB
bptjm-46	162	21	the	the	DET
bptjm-46	162	22	levels	level	NOUN
bptjm-46	162	23	of	of	ADP
bptjm-46	162	24	circulating	circulate	VERB
bptjm-46	162	25	igf-1	igf-1	NOUN
bptjm-46	162	26	(	(	PUNCT
bptjm-46	162	27	insulin	insulin	NOUN
bptjm-46	162	28	)	)	PUNCT
bptjm-46	162	29	in	in	ADP
bptjm-46	162	30	preventing	prevent	VERB
bptjm-46	162	31	the	the	DET
bptjm-46	162	32	nnk	nnk	ADV
bptjm-46	162	33	-	-	ADJ
bptjm-46	162	34	induced	induced	ADJ
bptjm-46	162	35	lung	lung	NOUN
bptjm-46	162	36	tumorigenesis45	tumorigenesis45	NOUN
bptjm-46	162	37	.	.	PUNCT
bptjm-46	163	1	in	in	ADP
bptjm-46	163	2	addition	addition	NOUN
bptjm-46	163	3	to	to	ADP
bptjm-46	163	4	its	its	PRON
bptjm-46	163	5	ability	ability	NOUN
bptjm-46	163	6	to	to	PART
bptjm-46	163	7	inhibit	inhibit	VERB
bptjm-46	163	8	the	the	DET
bptjm-46	163	9	mtor	mtor	PROPN
bptjm-46	163	10	pathway	pathway	NOUN
bptjm-46	163	11	,	,	PUNCT
bptjm-46	163	12	metformin	metformin	PROPN
bptjm-46	163	13	triggers	trigger	VERB
bptjm-46	163	14	a	a	DET
bptjm-46	163	15	decrease	decrease	NOUN
bptjm-46	163	16	in	in	ADP
bptjm-46	163	17	cap	cap	NOUN
bptjm-46	163	18	-	-	PUNCT
bptjm-46	163	19	dependent	dependent	ADJ
bptjm-46	163	20	translation	translation	NOUN
bptjm-46	163	21	.	.	PUNCT
bptjm-46	164	1	a	a	DET
bptjm-46	164	2	study	study	NOUN
bptjm-46	164	3	utilizes	utilize	VERB
bptjm-46	164	4	mcf-7	mcf-7	NOUN
bptjm-46	164	5	cells	cell	NOUN
bptjm-46	164	6	,	,	PUNCT
bptjm-46	164	7	metformin	metformin	NOUN
bptjm-46	164	8	treatment	treatment	NOUN
bptjm-46	164	9	and	and	CCONJ
bptjm-46	164	10	led	lead	VERB
bptjm-46	164	11	to	to	ADP
bptjm-46	164	12	a	a	DET
bptjm-46	164	13	maximal	maximal	ADJ
bptjm-46	164	14	inhibition	inhibition	NOUN
bptjm-46	164	15	of	of	ADP
bptjm-46	164	16	40	40	NUM
bptjm-46	164	17	%	%	NOUN
bptjm-46	164	18	in	in	ADP
bptjm-46	164	19	cap	cap	NOUN
bptjm-46	164	20	-	-	PUNCT
bptjm-46	164	21	dependent	dependent	ADJ
bptjm-46	164	22	translation45	translation45	NOUN
bptjm-46	164	23	.	.	PUNCT
bptjm-46	165	1	the	the	DET
bptjm-46	165	2	polysome	polysome	ADJ
bptjm-46	165	3	pro	pro	ADJ
bptjm-46	165	4	�	�	PROPN
bptjm-46	165	5	le	le	ADJ
bptjm-46	165	6	analysis	analysis	NOUN
bptjm-46	165	7	shows	show	VERB
bptjm-46	165	8	how	how	SCONJ
bptjm-46	165	9	the	the	DET
bptjm-46	165	10	metformin	metformin	NOUN
bptjm-46	165	11	treatment	treatment	NOUN
bptjm-46	165	12	of	of	ADP
bptjm-46	165	13	mcf-7	mcf-7	NOUN
bptjm-46	165	14	cells	cell	NOUN
bptjm-46	165	15	leads	lead	VERB
bptjm-46	165	16	to	to	ADP
bptjm-46	165	17	a	a	DET
bptjm-46	165	18	shift	shift	NOUN
bptjm-46	165	19	of	of	ADP
bptjm-46	165	20	mrnas	mrna	NOUN
bptjm-46	165	21	from	from	ADP
bptjm-46	165	22	heavy	heavy	ADJ
bptjm-46	165	23	to	to	ADP
bptjm-46	165	24	light	light	ADJ
bptjm-46	165	25	polysomes	polysome	NOUN
bptjm-46	165	26	and	and	CCONJ
bptjm-46	165	27	how	how	SCONJ
bptjm-46	165	28	concomitant	concomitant	ADJ
bptjm-46	165	29	increased	increase	VERB
bptjm-46	165	30	80s	80	NOUN
bptjm-46	165	31	ribosomes46	ribosomes46	NOUN
bptjm-46	165	32	.	.	PUNCT
bptjm-46	166	1	this	this	PRON
bptjm-46	166	2	suggests	suggest	VERB
bptjm-46	166	3	that	that	SCONJ
bptjm-46	166	4	metformin	metformin	NOUN
bptjm-46	166	5	can	can	AUX
bptjm-46	166	6	be	be	AUX
bptjm-46	166	7	a	a	DET
bptjm-46	166	8	treat	treat	NOUN
bptjm-46	166	9	and	and	CCONJ
bptjm-46	166	10	cause	cause	VERB
bptjm-46	166	11	signi	signi	ADJ
bptjm-46	166	12	�	�	NOUN
bptjm-46	166	13	cant	cant	NOUN
bptjm-46	166	14	impact	impact	NOUN
bptjm-46	166	15	on	on	ADP
bptjm-46	166	16	the	the	DET
bptjm-46	166	17	translation	translation	NOUN
bptjm-46	166	18	of	of	ADP
bptjm-46	166	19	speci	speci	PROPN
bptjm-46	166	20	�	�	PROPN
bptjm-46	166	21	c	c	PROPN
bptjm-46	166	22	mrnas	mrna	NOUN
bptjm-46	166	23	and	and	CCONJ
bptjm-46	166	24	leads	lead	VERB
bptjm-46	166	25	to	to	ADP
bptjm-46	166	26	alteration	alteration	NOUN
bptjm-46	166	27	of	of	ADP
bptjm-46	166	28	protein	protein	NOUN
bptjm-46	166	29	expression	expression	NOUN
bptjm-46	166	30	in	in	ADP
bptjm-46	166	31	cancer	cancer	NOUN
bptjm-46	166	32	cells	cell	NOUN
bptjm-46	166	33	.	.	PUNCT
bptjm-46	167	1	the	the	DET
bptjm-46	167	2	change	change	NOUN
bptjm-46	167	3	in	in	ADP
bptjm-46	167	4	polysome	polysome	ADJ
bptjm-46	167	5	pro	pro	NOUN
bptjm-46	167	6	�	�	NOUN
bptjm-46	167	7	les	le	NOUN
bptjm-46	167	8	towards	towards	ADP
bptjm-46	167	9	lighter	light	ADJ
bptjm-46	167	10	polysomes	polysome	NOUN
bptjm-46	167	11	indicates	indicate	VERB
bptjm-46	167	12	a	a	DET
bptjm-46	167	13	reduction	reduction	NOUN
bptjm-46	167	14	in	in	ADP
bptjm-46	167	15	the	the	DET
bptjm-46	167	16	translation	translation	NOUN
bptjm-46	167	17	e	e	NOUN
bptjm-46	167	18	�	�	PROPN
bptjm-46	167	19	ciency	ciency	NOUN
bptjm-46	167	20	of	of	ADP
bptjm-46	167	21	speci	speci	PROPN
bptjm-46	167	22	�	�	PROPN
bptjm-46	167	23	c	c	PROPN
bptjm-46	167	24	mrnas	mrna	NOUN
bptjm-46	167	25	.	.	PUNCT
bptjm-46	168	1	this	this	PRON
bptjm-46	168	2	can	can	AUX
bptjm-46	168	3	help	help	VERB
bptjm-46	168	4	with	with	ADP
bptjm-46	168	5	further	further	ADJ
bptjm-46	168	6	implication	implication	NOUN
bptjm-46	168	7	for	for	ADP
bptjm-46	168	8	cancer	cancer	NOUN
bptjm-46	168	9	cells	cell	NOUN
bptjm-46	168	10	that	that	PRON
bptjm-46	168	11	rely	rely	VERB
bptjm-46	168	12	on	on	ADP
bptjm-46	168	13	increased	increase	VERB
bptjm-46	168	14	protein	protein	NOUN
bptjm-46	168	15	synthesis	synthesis	NOUN
bptjm-46	168	16	for	for	ADP
bptjm-46	168	17	their	their	PRON
bptjm-46	168	18	survival	survival	NOUN
bptjm-46	168	19	and	and	CCONJ
bptjm-46	168	20	proliferation47	proliferation47	NOUN
bptjm-46	168	21	.	.	PUNCT
bptjm-46	169	1	the	the	DET
bptjm-46	169	2	increase	increase	NOUN
bptjm-46	169	3	of	of	ADP
bptjm-46	169	4	80s	80	NOUN
bptjm-46	169	5	ribosomes	ribosome	NOUN
bptjm-46	169	6	indicates	indicate	VERB
bptjm-46	169	7	that	that	SCONJ
bptjm-46	169	8	metformin	metformin	NOUN
bptjm-46	169	9	treatment	treatment	NOUN
bptjm-46	169	10	may	may	AUX
bptjm-46	169	11	also	also	ADV
bptjm-46	169	12	a	a	DET
bptjm-46	169	13	�	�	NOUN
bptjm-46	169	14	ect	ect	VERB
bptjm-46	169	15	the	the	DET
bptjm-46	169	16	biogenesis	biogenesis	NOUN
bptjm-46	169	17	of	of	ADP
bptjm-46	169	18	ribosomes	ribosome	NOUN
bptjm-46	169	19	,	,	PUNCT
bptjm-46	169	20	which	which	PRON
bptjm-46	169	21	is	be	AUX
bptjm-46	169	22	essential	essential	ADJ
bptjm-46	169	23	for	for	ADP
bptjm-46	169	24	protein	protein	NOUN
bptjm-46	169	25	synthesis	synthesis	NOUN
bptjm-46	169	26	.	.	PUNCT
bptjm-46	170	1	this	this	PRON
bptjm-46	170	2	decreases	decrease	VERB
bptjm-46	170	3	the	the	DET
bptjm-46	170	4	rate	rate	NOUN
bptjm-46	170	5	of	of	ADP
bptjm-46	170	6	protein	protein	NOUN
bptjm-46	170	7	synthesis	synthesis	NOUN
bptjm-46	170	8	within	within	ADP
bptjm-46	170	9	cancer	cancer	NOUN
bptjm-46	170	10	hosts	host	NOUN
bptjm-46	170	11	,	,	PUNCT
bptjm-46	170	12	which	which	PRON
bptjm-46	170	13	can	can	AUX
bptjm-46	170	14	then	then	ADV
bptjm-46	170	15	be	be	AUX
bptjm-46	170	16	added	add	VERB
bptjm-46	170	17	to	to	ADP
bptjm-46	170	18	the	the	DET
bptjm-46	170	19	growing	grow	VERB
bptjm-46	170	20	body	body	NOUN
bptjm-46	170	21	of	of	ADP
bptjm-46	170	22	evidence	evidence	NOUN
bptjm-46	170	23	supporting	support	VERB
bptjm-46	170	24	the	the	DET
bptjm-46	170	25	potential	potential	NOUN
bptjm-46	170	26	of	of	ADP
bptjm-46	170	27	metformin	metformin	NOUN
bptjm-46	170	28	as	as	ADP
bptjm-46	170	29	a	a	DET
bptjm-46	170	30	therapeutic	therapeutic	ADJ
bptjm-46	170	31	agent	agent	NOUN
bptjm-46	170	32	for	for	ADP
bptjm-46	170	33	cancer	cancer	NOUN
bptjm-46	170	34	.	.	PUNCT
bptjm-46	171	1	in	in	ADP
bptjm-46	171	2	mcf-7	mcf-7	NUM
bptjm-46	171	3	breast	breast	NOUN
bptjm-46	171	4	cancer	cancer	NOUN
bptjm-46	171	5	cells	cell	NOUN
bptjm-46	171	6	,	,	PUNCT
bptjm-46	171	7	metformin	metformin	NOUN
bptjm-46	171	8	has	have	AUX
bptjm-46	171	9	been	be	AUX
bptjm-46	171	10	shown	show	VERB
bptjm-46	171	11	to	to	PART
bptjm-46	171	12	inhibit	inhibit	VERB
bptjm-46	171	13	translation	translation	NOUN
bptjm-46	171	14	initiation	initiation	NOUN
bptjm-46	171	15	by	by	ADP
bptjm-46	171	16	activating	activate	VERB
bptjm-46	171	17	smp	smp	NOUN
bptjm-46	171	18	-	-	PUNCT
bptjm-46	171	19	activated	activate	VERB
bptjm-46	171	20	protein	protein	NOUN
bptjm-46	171	21	kinase	kinase	NOUN
bptjm-46	171	22	(	(	PUNCT
bptjm-46	171	23	ampk	ampk	PROPN
bptjm-46	171	24	)	)	PUNCT
bptjm-46	171	25	through	through	ADP
bptjm-46	171	26	its	its	PRON
bptjm-46	171	27	upstream	upstream	PROPN
bptjm-46	171	28	kinase	kinase	NOUN
bptjm-46	171	29	,	,	PUNCT
bptjm-46	171	30	liver	liver	NOUN
bptjm-46	171	31	kinase	kinase	PROPN
bptjm-46	171	32	b1	b1	PROPN
bptjm-46	171	33	(	(	PUNCT
bptjm-46	171	34	lkb1)48	lkb1)48	PROPN
bptjm-46	171	35	.	.	PUNCT
bptjm-46	172	1	this	this	PRON
bptjm-46	172	2	results	result	VERB
bptjm-46	172	3	in	in	ADP
bptjm-46	172	4	the	the	DET
bptjm-46	172	5	inhibition	inhibition	NOUN
bptjm-46	172	6	of	of	ADP
bptjm-46	172	7	the	the	DET
bptjm-46	172	8	mammalian	mammalian	ADJ
bptjm-46	172	9	target	target	NOUN
bptjm-46	172	10	of	of	ADP
bptjm-46	172	11	mtorc1	mtorc1	NOUN
bptjm-46	172	12	.	.	PUNCT
bptjm-46	173	1	although	although	SCONJ
bptjm-46	173	2	in	in	ADP
bptjm-46	173	3	contrast	contrast	NOUN
bptjm-46	173	4	,	,	PUNCT
bptjm-46	173	5	in	in	ADP
bptjm-46	173	6	mda	mda	PROPN
bptjm-46	173	7	-	-	PUNCT
bptjm-46	173	8	mb-231	mb-231	PROPN
bptjm-46	173	9	breast	breast	NOUN
bptjm-46	173	10	cancer	cancer	NOUN
bptjm-46	173	11	cells	cell	NOUN
bptjm-46	173	12	,	,	PUNCT
bptjm-46	173	13	did	do	AUX
bptjm-46	173	14	n’t	not	PART
bptjm-46	173	15	express	express	VERB
bptjm-46	173	16	lkb1	lkb1	PROPN
bptjm-46	173	17	mrna	mrna	PROPN
bptjm-46	173	18	,	,	PUNCT
bptjm-46	173	19	metformin	metformin	PROPN
bptjm-46	173	20	had	have	VERB
bptjm-46	173	21	no	no	DET
bptjm-46	173	22	e	e	NOUN
bptjm-46	173	23	�	�	NOUN
bptjm-46	173	24	ect	ect	NOUN
bptjm-46	173	25	on	on	ADP
bptjm-46	173	26	its	its	PRON
bptjm-46	173	27	protein	protein	NOUN
bptjm-46	173	28	synthesis	synthesis	NOUN
bptjm-46	173	29	,	,	PUNCT
bptjm-46	173	30	con	con	PROPN
bptjm-46	173	31	�	�	PROPN
bptjm-46	173	32	rming	rme	VERB
bptjm-46	173	33	the	the	DET
bptjm-46	173	34	requirement	requirement	NOUN
bptjm-46	173	35	of	of	ADP
bptjm-46	173	36	lkb1	lkb1	PROPN
bptjm-46	173	37	for	for	ADP
bptjm-46	173	38	inhibition	inhibition	NOUN
bptjm-46	173	39	of	of	ADP
bptjm-46	173	40	translation	translation	NOUN
bptjm-46	173	41	by	by	ADP
bptjm-46	173	42	metformin	metformin	NOUN
bptjm-46	173	43	in	in	ADP
bptjm-46	173	44	mcr-7	mcr-7	PUNCT
bptjm-46	173	45	breast	breast	NOUN
bptjm-46	173	46	cancer	cancer	NOUN
bptjm-46	173	47	cells49	cells49	NOUN
bptjm-46	173	48	.	.	PUNCT
bptjm-46	174	1	this	this	DET
bptjm-46	174	2	con	con	PROPN
bptjm-46	174	3	�	�	PROPN
bptjm-46	174	4	rms	rm	VERB
bptjm-46	174	5	the	the	DET
bptjm-46	174	6	requirement	requirement	NOUN
bptjm-46	174	7	of	of	ADP
bptjm-46	174	8	lkb1	lkb1	PROPN
bptjm-46	174	9	for	for	ADP
bptjm-46	174	10	inhibition	inhibition	NOUN
bptjm-46	174	11	of	of	ADP
bptjm-46	174	12	translation	translation	NOUN
bptjm-46	174	13	by	by	ADP
bptjm-46	174	14	metformin	metformin	NOUN
bptjm-46	174	15	in	in	ADP
bptjm-46	174	16	mcf-7	mcf-7	PUNCT
bptjm-46	174	17	berkeley	berkeley	PROPN
bptjm-46	174	18	pharma	pharma	PROPN
bptjm-46	174	19	tech	tech	NOUN
bptjm-46	174	20	journal	journal	NOUN
bptjm-46	174	21	of	of	ADP
bptjm-46	174	22	medicine	medicine	NOUN
bptjm-46	174	23	|	|	ADV
bptjm-46	174	24	113	113	NUM
bptjm-46	174	25	breast	breast	NOUN
bptjm-46	174	26	cancer	cancer	NOUN
bptjm-46	174	27	cells	cell	NOUN
bptjm-46	174	28	.	.	PUNCT
bptjm-46	175	1	it	it	PRON
bptjm-46	175	2	is	be	AUX
bptjm-46	175	3	an	an	DET
bptjm-46	175	4	important	important	ADJ
bptjm-46	175	5	biomarker	biomarker	NOUN
bptjm-46	175	6	for	for	ADP
bptjm-46	175	7	predicting	predict	VERB
bptjm-46	175	8	the	the	DET
bptjm-46	175	9	response	response	NOUN
bptjm-46	175	10	to	to	ADP
bptjm-46	175	11	metformin	metformin	NOUN
bptjm-46	175	12	treatment	treatment	NOUN
bptjm-46	175	13	.	.	PUNCT
bptjm-46	176	1	7	7	X
bptjm-46	176	2	.	.	X
bptjm-46	176	3	conclusion	conclusion	NOUN
bptjm-46	176	4	as	as	SCONJ
bptjm-46	176	5	discussed	discuss	VERB
bptjm-46	176	6	,	,	PUNCT
bptjm-46	176	7	the	the	DET
bptjm-46	176	8	development	development	NOUN
bptjm-46	176	9	of	of	ADP
bptjm-46	176	10	diabetes	diabetes	NOUN
bptjm-46	176	11	is	be	AUX
bptjm-46	176	12	a	a	DET
bptjm-46	176	13	result	result	NOUN
bptjm-46	176	14	of	of	ADP
bptjm-46	176	15	imbalance	imbalance	NOUN
bptjm-46	176	16	between	between	ADP
bptjm-46	176	17	glucose	glucose	NOUN
bptjm-46	176	18	metabolism	metabolism	NOUN
bptjm-46	176	19	and	and	CCONJ
bptjm-46	176	20	anabolism	anabolism	NOUN
bptjm-46	176	21	.	.	PUNCT
bptjm-46	177	1	this	this	DET
bptjm-46	177	2	distorted	distort	VERB
bptjm-46	177	3	metabolic	metabolic	NOUN
bptjm-46	177	4	system	system	NOUN
bptjm-46	177	5	can	can	AUX
bptjm-46	177	6	be	be	AUX
bptjm-46	177	7	caused	cause	VERB
bptjm-46	177	8	by	by	ADP
bptjm-46	177	9	abnormally	abnormally	ADV
bptjm-46	177	10	increased	increase	VERB
bptjm-46	177	11	glucose	glucose	NOUN
bptjm-46	177	12	intake	intake	NOUN
bptjm-46	177	13	and	and	CCONJ
bptjm-46	177	14	the	the	DET
bptjm-46	177	15	subsequent	subsequent	ADJ
bptjm-46	177	16	development	development	NOUN
bptjm-46	177	17	of	of	ADP
bptjm-46	177	18	insulin	insulin	NOUN
bptjm-46	177	19	resistance	resistance	NOUN
bptjm-46	177	20	,	,	PUNCT
bptjm-46	177	21	causing	cause	VERB
bptjm-46	177	22	t2	t2	NOUN
bptjm-46	177	23	dm	dm	NOUN
bptjm-46	177	24	.	.	PUNCT
bptjm-46	178	1	furthermore	furthermore	ADV
bptjm-46	178	2	,	,	PUNCT
bptjm-46	178	3	the	the	DET
bptjm-46	178	4	establishment	establishment	NOUN
bptjm-46	178	5	of	of	ADP
bptjm-46	178	6	t2	t2	NOUN
bptjm-46	178	7	dm	dm	NOUN
bptjm-46	178	8	,	,	PUNCT
bptjm-46	178	9	along	along	ADP
bptjm-46	178	10	with	with	ADP
bptjm-46	178	11	an	an	DET
bptjm-46	178	12	anaerobic	anaerobic	NOUN
bptjm-46	178	13	environment	environment	NOUN
bptjm-46	178	14	that	that	PRON
bptjm-46	178	15	is	be	AUX
bptjm-46	178	16	bene	bene	NOUN
bptjm-46	178	17	�	�	PROPN
bptjm-46	178	18	cial	cial	NOUN
bptjm-46	178	19	for	for	ADP
bptjm-46	178	20	the	the	DET
bptjm-46	178	21	cancer	cancer	NOUN
bptjm-46	178	22	progression	progression	NOUN
bptjm-46	178	23	,	,	PUNCT
bptjm-46	178	24	will	will	AUX
bptjm-46	178	25	reshape	reshape	VERB
bptjm-46	178	26	the	the	DET
bptjm-46	178	27	metabolic	metabolic	NOUN
bptjm-46	178	28	dependence	dependence	NOUN
bptjm-46	178	29	of	of	ADP
bptjm-46	178	30	tumor	tumor	NOUN
bptjm-46	178	31	from	from	ADP
bptjm-46	178	32	mitochondrial	mitochondrial	ADJ
bptjm-46	178	33	respiration	respiration	NOUN
bptjm-46	178	34	to	to	ADP
bptjm-46	178	35	aerobic	aerobic	ADJ
bptjm-46	178	36	glycolysis	glycolysis	NOUN
bptjm-46	178	37	.	.	PUNCT
bptjm-46	179	1	extensive	extensive	ADJ
bptjm-46	179	2	supply	supply	NOUN
bptjm-46	179	3	of	of	ADP
bptjm-46	179	4	glucose	glucose	NOUN
bptjm-46	179	5	can	can	AUX
bptjm-46	179	6	be	be	AUX
bptjm-46	179	7	advantageous	advantageous	ADJ
bptjm-46	179	8	for	for	ADP
bptjm-46	179	9	cancers	cancer	NOUN
bptjm-46	179	10	with	with	ADP
bptjm-46	179	11	high	high	ADJ
bptjm-46	179	12	energy	energy	NOUN
bptjm-46	179	13	demand	demand	NOUN
bptjm-46	179	14	to	to	ADP
bptjm-46	179	15	ful	ful	PROPN
bptjm-46	179	16	�	�	PROPN
bptjm-46	179	17	ll	ll	NOUN
bptjm-46	179	18	its	its	PRON
bptjm-46	179	19	need	need	NOUN
bptjm-46	179	20	of	of	ADP
bptjm-46	179	21	rapid	rapid	ADJ
bptjm-46	179	22	division	division	NOUN
bptjm-46	179	23	and	and	CCONJ
bptjm-46	179	24	proliferation	proliferation	NOUN
bptjm-46	179	25	.	.	PUNCT
bptjm-46	180	1	therefore	therefore	ADV
bptjm-46	180	2	,	,	PUNCT
bptjm-46	180	3	a	a	DET
bptjm-46	180	4	new	new	ADJ
bptjm-46	180	5	target	target	NOUN
bptjm-46	180	6	for	for	ADP
bptjm-46	180	7	non	non	ADJ
bptjm-46	180	8	-	-	ADJ
bptjm-46	180	9	invasive	invasive	ADJ
bptjm-46	180	10	cancer	cancer	NOUN
bptjm-46	180	11	treatment	treatment	NOUN
bptjm-46	180	12	emerges	emerge	VERB
bptjm-46	180	13	.	.	PUNCT
bptjm-46	181	1	by	by	ADP
bptjm-46	181	2	limiting	limit	VERB
bptjm-46	181	3	the	the	DET
bptjm-46	181	4	energy	energy	NOUN
bptjm-46	181	5	in	in	ADP
bptjm-46	181	6	�	�	PROPN
bptjm-46	181	7	ux	ux	NOUN
bptjm-46	181	8	to	to	ADP
bptjm-46	181	9	tumor	tumor	NOUN
bptjm-46	181	10	tissue	tissue	NOUN
bptjm-46	181	11	with	with	ADP
bptjm-46	181	12	either	either	CCONJ
bptjm-46	181	13	direct	direct	ADJ
bptjm-46	181	14	blockage	blockage	NOUN
bptjm-46	181	15	on	on	ADP
bptjm-46	181	16	membrane	membrane	NOUN
bptjm-46	181	17	receptors	receptor	NOUN
bptjm-46	181	18	or	or	CCONJ
bptjm-46	181	19	indirect	indirect	ADJ
bptjm-46	181	20	pathways	pathway	NOUN
bptjm-46	181	21	that	that	PRON
bptjm-46	181	22	induce	induce	VERB
bptjm-46	181	23	speci	speci	ADJ
bptjm-46	181	24	�	�	PROPN
bptjm-46	181	25	c	c	NOUN
bptjm-46	181	26	cell	cell	NOUN
bptjm-46	181	27	killing	killing	NOUN
bptjm-46	181	28	,	,	PUNCT
bptjm-46	181	29	three	three	NUM
bptjm-46	181	30	of	of	ADP
bptjm-46	181	31	the	the	DET
bptjm-46	181	32	potential	potential	ADJ
bptjm-46	181	33	candidates	candidate	NOUN
bptjm-46	181	34	are	be	AUX
bptjm-46	181	35	available	available	ADJ
bptjm-46	181	36	for	for	ADP
bptjm-46	181	37	consideration	consideration	NOUN
bptjm-46	181	38	,	,	PUNCT
bptjm-46	181	39	which	which	PRON
bptjm-46	181	40	are	be	AUX
bptjm-46	181	41	panitumumab	panitumumab	NOUN
bptjm-46	181	42	,	,	PUNCT
bptjm-46	181	43	fasentin	fasentin	NOUN
bptjm-46	181	44	,	,	PUNCT
bptjm-46	181	45	and	and	CCONJ
bptjm-46	181	46	metformin	metformin	NOUN
bptjm-46	181	47	.	.	PUNCT
bptjm-46	182	1	even	even	ADV
bptjm-46	182	2	though	though	SCONJ
bptjm-46	182	3	all	all	DET
bptjm-46	182	4	the	the	DET
bptjm-46	182	5	mentioned	mention	VERB
bptjm-46	182	6	treatments	treatment	NOUN
bptjm-46	182	7	are	be	AUX
bptjm-46	182	8	proven	prove	VERB
bptjm-46	182	9	to	to	PART
bptjm-46	182	10	be	be	AUX
bptjm-46	182	11	e	e	NOUN
bptjm-46	182	12	�	�	NOUN
bptjm-46	182	13	ective	ective	ADJ
bptjm-46	182	14	to	to	ADP
bptjm-46	182	15	some	some	DET
bptjm-46	182	16	extent	extent	NOUN
bptjm-46	182	17	,	,	PUNCT
bptjm-46	182	18	assistance	assistance	NOUN
bptjm-46	182	19	from	from	ADP
bptjm-46	182	20	corresponding	correspond	VERB
bptjm-46	182	21	drugs	drug	NOUN
bptjm-46	182	22	and	and	CCONJ
bptjm-46	182	23	therapies	therapy	NOUN
bptjm-46	182	24	is	be	AUX
bptjm-46	182	25	highly	highly	ADV
bptjm-46	182	26	recommended	recommend	VERB
bptjm-46	182	27	since	since	SCONJ
bptjm-46	182	28	some	some	PRON
bptjm-46	182	29	of	of	ADP
bptjm-46	182	30	the	the	DET
bptjm-46	182	31	directed	direct	VERB
bptjm-46	182	32	pathways	pathway	NOUN
bptjm-46	182	33	are	be	AUX
bptjm-46	182	34	not	not	PART
bptjm-46	182	35	exclusive	exclusive	ADJ
bptjm-46	182	36	to	to	ADP
bptjm-46	182	37	cancer	cancer	NOUN
bptjm-46	182	38	,	,	PUNCT
bptjm-46	182	39	which	which	PRON
bptjm-46	182	40	leaves	leave	VERB
bptjm-46	182	41	potential	potential	ADJ
bptjm-46	182	42	risk	risk	NOUN
bptjm-46	182	43	of	of	ADP
bptjm-46	182	44	a	a	DET
bptjm-46	182	45	�	�	NOUN
bptjm-46	182	46	ecting	ecte	VERB
bptjm-46	182	47	normal	normal	ADJ
bptjm-46	182	48	cell	cell	NOUN
bptjm-46	182	49	functioning	function	VERB
bptjm-46	182	50	.	.	PUNCT
bptjm-46	183	1	moreover	moreover	ADV
bptjm-46	183	2	,	,	PUNCT
bptjm-46	183	3	many	many	ADJ
bptjm-46	183	4	of	of	ADP
bptjm-46	183	5	the	the	DET
bptjm-46	183	6	mentioned	mention	VERB
bptjm-46	183	7	pathways	pathway	NOUN
bptjm-46	183	8	are	be	AUX
bptjm-46	183	9	distinct	distinct	ADJ
bptjm-46	183	10	from	from	ADP
bptjm-46	183	11	each	each	DET
bptjm-46	183	12	other	other	ADJ
bptjm-46	183	13	,	,	PUNCT
bptjm-46	183	14	which	which	PRON
bptjm-46	183	15	gives	give	VERB
bptjm-46	183	16	the	the	DET
bptjm-46	183	17	possibility	possibility	NOUN
bptjm-46	183	18	of	of	ADP
bptjm-46	183	19	combinational	combinational	ADJ
bptjm-46	183	20	use	use	NOUN
bptjm-46	183	21	,	,	PUNCT
bptjm-46	183	22	similar	similar	ADJ
bptjm-46	183	23	to	to	ADP
bptjm-46	183	24	a	a	DET
bptjm-46	183	25	cocktail	cocktail	NOUN
bptjm-46	183	26	therapy	therapy	NOUN
bptjm-46	183	27	for	for	ADP
bptjm-46	183	28	hiv	hiv	PROPN
bptjm-46	183	29	patients50	patients50	NOUN
bptjm-46	183	30	.	.	PUNCT
bptjm-46	184	1	berkeley	berkeley	PROPN
bptjm-46	184	2	pharma	pharma	PROPN
bptjm-46	184	3	tech	tech	PROPN
bptjm-46	184	4	journal	journal	NOUN
bptjm-46	184	5	of	of	ADP
bptjm-46	184	6	medicine	medicine	NOUN
bptjm-46	184	7	|	|	ADV
bptjm-46	184	8	114	114	NUM
bptjm-46	184	9	references	reference	NOUN
bptjm-46	184	10	1	1	NUM
bptjm-46	184	11	.	.	PUNCT
bptjm-46	184	12	world	world	PROPN
bptjm-46	184	13	health	health	PROPN
bptjm-46	184	14	organization	organization	NOUN
bptjm-46	184	15	,	,	PUNCT
bptjm-46	184	16	cancer	cancer	NOUN
bptjm-46	184	17	overview	overview	NOUN
bptjm-46	184	18	.	.	PUNCT
bptjm-46	185	1	https://www.who.int/news-room	https://www.who.int/news-room	NOUN
bptjm-46	185	2	/fact	/fact	NOUN
bptjm-46	185	3	-	-	PUNCT
bptjm-46	185	4	sheets	sheet	NOUN
bptjm-46	185	5	/	/	SYM
bptjm-46	185	6	detail	detail	NOUN
bptjm-46	185	7	/	/	SYM
bptjm-46	185	8	cancer	cancer	NOUN
bptjm-46	185	9	2	2	NUM
bptjm-46	185	10	.	.	X
bptjm-46	186	1	tu	tu	PROPN
bptjm-46	186	2	h	h	PROPN
bptjm-46	186	3	,	,	PUNCT
bptjm-46	186	4	wen	wen	PROPN
bptjm-46	186	5	cp	cp	PROPN
bptjm-46	186	6	,	,	PUNCT
bptjm-46	186	7	tsai	tsai	PROPN
bptjm-46	186	8	sp	sp	PROPN
bptjm-46	186	9	,	,	PUNCT
bptjm-46	186	10	et	et	PROPN
bptjm-46	186	11	al	al	PROPN
bptjm-46	186	12	.	.	PUNCT
bptjm-46	187	1	cancer	cancer	NOUN
bptjm-46	187	2	risk	risk	NOUN
bptjm-46	187	3	associated	associate	VERB
bptjm-46	187	4	with	with	ADP
bptjm-46	187	5	chronic	chronic	ADJ
bptjm-46	187	6	diseases	disease	NOUN
bptjm-46	187	7	and	and	CCONJ
bptjm-46	187	8	disease	disease	NOUN
bptjm-46	187	9	markers	marker	NOUN
bptjm-46	187	10	:	:	PUNCT
bptjm-46	187	11	prospective	prospective	ADJ
bptjm-46	187	12	cohort	cohort	NOUN
bptjm-46	187	13	study	study	NOUN
bptjm-46	187	14	.	.	PUNCT
bptjm-46	188	1	bmj	bmj	PROPN
bptjm-46	188	2	.	.	PUNCT
bptjm-46	188	3	2018;360	2018;360	NUM
bptjm-46	188	4	:	:	PUNCT
bptjm-46	189	1	k134	k134	PROPN
bptjm-46	189	2	.	.	PROPN
bptjm-46	190	1	published	publish	VERB
bptjm-46	190	2	2018	2018	NUM
bptjm-46	190	3	jan	jan	PROPN
bptjm-46	190	4	31	31	NUM
bptjm-46	190	5	.	.	PUNCT
bptjm-46	191	1	doi:10.1136	doi:10.1136	NOUN
bptjm-46	191	2	/	/	SYM
bptjm-46	192	1	bmj.k134	bmj.k134	NUM
bptjm-46	192	2	3	3	X
bptjm-46	192	3	.	.	PUNCT
bptjm-46	192	4	kitabchi	kitabchi	PROPN
bptjm-46	192	5	ae	ae	PROPN
bptjm-46	192	6	,	,	PUNCT
bptjm-46	192	7	umpierrez	umpierrez	PROPN
bptjm-46	192	8	ge	ge	PROPN
bptjm-46	192	9	,	,	PUNCT
bptjm-46	192	10	miles	miles	PROPN
bptjm-46	192	11	jm	jm	PROPN
bptjm-46	192	12	,	,	PUNCT
bptjm-46	192	13	fisher	fisher	PROPN
bptjm-46	193	1	jn	jn	PROPN
bptjm-46	193	2	.	.	PROPN
bptjm-46	194	1	hyperglycemic	hyperglycemic	ADJ
bptjm-46	194	2	crises	crisis	NOUN
bptjm-46	194	3	in	in	ADP
bptjm-46	194	4	adult	adult	NOUN
bptjm-46	194	5	patients	patient	NOUN
bptjm-46	194	6	with	with	ADP
bptjm-46	194	7	diabetes	diabetes	NOUN
bptjm-46	194	8	.	.	PUNCT
bptjm-46	195	1	diabetes	diabetes	NOUN
bptjm-46	195	2	care	care	NOUN
bptjm-46	195	3	.	.	PUNCT
bptjm-46	196	1	2009;32(7):1335	2009;32(7):1335	NUM
bptjm-46	196	2	-	-	SYM
bptjm-46	196	3	1343	1343	NUM
bptjm-46	196	4	.	.	PUNCT
bptjm-46	197	1	doi:10.2337	doi:10.2337	NOUN
bptjm-46	197	2	/	/	PUNCT
bptjm-46	198	1	dc09	dc09	NOUN
bptjm-46	198	2	-	-	PUNCT
bptjm-46	198	3	9032	9032	NUM
bptjm-46	198	4	4	4	NUM
bptjm-46	198	5	.	.	PUNCT
bptjm-46	199	1	ghoshal	ghoshal	NOUN
bptjm-46	199	2	,	,	PUNCT
bptjm-46	199	3	k.	k.	PROPN
bptjm-46	199	4	,	,	PUNCT
bptjm-46	199	5	chatterjee	chatterjee	PROPN
bptjm-46	199	6	,	,	PUNCT
bptjm-46	199	7	t.	t.	PROPN
bptjm-46	199	8	,	,	PUNCT
bptjm-46	199	9	chowdhury	chowdhury	PROPN
bptjm-46	199	10	,	,	PUNCT
bptjm-46	199	11	s.	s.	PROPN
bptjm-46	199	12	et	et	PROPN
bptjm-46	199	13	al	al	PROPN
bptjm-46	199	14	.	.	PUNCT
bptjm-46	200	1	adiponectin	adiponectin	NOUN
bptjm-46	200	2	genetic	genetic	ADJ
bptjm-46	200	3	variant	variant	NOUN
bptjm-46	200	4	and	and	CCONJ
bptjm-46	200	5	expression	expression	NOUN
bptjm-46	200	6	coupled	couple	VERB
bptjm-46	200	7	with	with	ADP
bptjm-46	200	8	lipid	lipid	NOUN
bptjm-46	200	9	peroxidation	peroxidation	NOUN
bptjm-46	200	10	reveal	reveal	VERB
bptjm-46	200	11	new	new	ADJ
bptjm-46	200	12	signatures	signature	NOUN
bptjm-46	200	13	in	in	ADP
bptjm-46	200	14	diabetic	diabetic	ADJ
bptjm-46	200	15	dyslipidemia	dyslipidemia	NOUN
bptjm-46	200	16	.	.	PUNCT
bptjm-46	201	1	biochemgenet	biochemgenet	PROPN
bptjm-46	201	2	59	59	NUM
bptjm-46	201	3	,	,	PUNCT
bptjm-46	201	4	781–798	781–798	NUM
bptjm-46	201	5	(	(	PUNCT
bptjm-46	201	6	2021	2021	NUM
bptjm-46	201	7	)	)	PUNCT
bptjm-46	201	8	.	.	PUNCT
bptjm-46	202	1	https://doi.org/10.1007/s10528-021-10030-5	https://doi.org/10.1007/s10528-021-10030-5	NUM
bptjm-46	202	2	5	5	NUM
bptjm-46	202	3	.	.	PUNCT
bptjm-46	202	4	reneau	reneau	PROPN
bptjm-46	202	5	,	,	PUNCT
bptjm-46	202	6	james	james	PROPN
bptjm-46	202	7	et	et	PROPN
bptjm-46	202	8	al	al	PROPN
bptjm-46	202	9	.	.	PUNCT
bptjm-46	203	1	“	"	PUNCT
bptjm-46	203	2	e	e	X
bptjm-46	203	3	�	�	NOUN
bptjm-46	203	4	ect	ect	NOUN
bptjm-46	203	5	of	of	ADP
bptjm-46	203	6	adiposity	adiposity	NOUN
bptjm-46	203	7	on	on	ADP
bptjm-46	203	8	tissue	tissue	NOUN
bptjm-46	203	9	-	-	PUNCT
bptjm-46	203	10	speci	speci	NOUN
bptjm-46	203	11	�	�	PROPN
bptjm-46	203	12	c	c	NOUN
bptjm-46	203	13	adiponectin	adiponectin	NOUN
bptjm-46	203	14	secretion	secretion	NOUN
bptjm-46	203	15	.	.	PUNCT
bptjm-46	203	16	”	"	PUNCT
bptjm-46	204	1	plos	plos	PROPN
bptjm-46	204	2	one	one	NUM
bptjm-46	204	3	vol	vol	NOUN
bptjm-46	204	4	.	.	PUNCT
bptjm-46	205	1	13,6	13,6	NUM
bptjm-46	205	2	e0198889	e0198889	NOUN
bptjm-46	205	3	.	.	PUNCT
bptjm-46	206	1	20	20	NUM
bptjm-46	206	2	jun	jun	PROPN
bptjm-46	206	3	.	.	PROPN
bptjm-46	206	4	2018	2018	NUM
bptjm-46	206	5	,	,	PUNCT
bptjm-46	206	6	doi:10.1371	doi:10.1371	NOUN
bptjm-46	206	7	/	/	SYM
bptjm-46	207	1	journal.pone.0198889	journal.pone.0198889	PROPN
bptjm-46	207	2	6	6	NUM
bptjm-46	207	3	.	.	PUNCT
bptjm-46	208	1	margetic	margetic	ADJ
bptjm-46	208	2	,	,	PUNCT
bptjm-46	208	3	s	s	PART
bptjm-46	208	4	et	et	NOUN
bptjm-46	208	5	al	al	PROPN
bptjm-46	208	6	.	.	PUNCT
bptjm-46	209	1	“	"	PUNCT
bptjm-46	209	2	leptin	leptin	NOUN
bptjm-46	209	3	:	:	PUNCT
bptjm-46	209	4	a	a	DET
bptjm-46	209	5	review	review	NOUN
bptjm-46	209	6	of	of	ADP
bptjm-46	209	7	its	its	PRON
bptjm-46	209	8	peripheral	peripheral	ADJ
bptjm-46	209	9	actions	action	NOUN
bptjm-46	209	10	and	and	CCONJ
bptjm-46	209	11	interactions	interaction	NOUN
bptjm-46	209	12	.	.	PUNCT
bptjm-46	209	13	”	"	PUNCT
bptjm-46	210	1	international	international	ADJ
bptjm-46	210	2	journal	journal	NOUN
bptjm-46	210	3	of	of	ADP
bptjm-46	210	4	obesity	obesity	NOUN
bptjm-46	210	5	and	and	CCONJ
bptjm-46	210	6	related	relate	VERB
bptjm-46	210	7	metabolic	metabolic	NOUN
bptjm-46	210	8	disorders	disorder	NOUN
bptjm-46	210	9	:	:	PUNCT
bptjm-46	210	10	journal	journal	NOUN
bptjm-46	210	11	of	of	ADP
bptjm-46	210	12	the	the	DET
bptjm-46	210	13	international	international	ADJ
bptjm-46	210	14	association	association	NOUN
bptjm-46	210	15	for	for	ADP
bptjm-46	210	16	the	the	DET
bptjm-46	210	17	study	study	NOUN
bptjm-46	210	18	of	of	ADP
bptjm-46	210	19	obesity	obesity	NOUN
bptjm-46	210	20	vol	vol	NOUN
bptjm-46	210	21	.	.	PUNCT
bptjm-46	210	22	26,11	26,11	NUM
bptjm-46	210	23	(	(	PUNCT
bptjm-46	210	24	2002	2002	NUM
bptjm-46	210	25	):	):	PUNCT
bptjm-46	210	26	1407	1407	NUM
bptjm-46	210	27	-	-	SYM
bptjm-46	210	28	33	33	NUM
bptjm-46	210	29	.	.	PUNCT
bptjm-46	211	1	doi:10.1038	doi:10.1038	PROPN
bptjm-46	211	2	/	/	SYM
bptjm-46	211	3	sj.ijo.0802142	sj.ijo.0802142	PROPN
bptjm-46	211	4	7	7	NUM
bptjm-46	211	5	.	.	PUNCT
bptjm-46	211	6	dimitriadis	dimitriadis	PROPN
bptjm-46	211	7	,	,	PUNCT
bptjm-46	211	8	george	george	PROPN
bptjm-46	211	9	et	et	PROPN
bptjm-46	211	10	al	al	PROPN
bptjm-46	211	11	.	.	PUNCT
bptjm-46	212	1	“	"	PUNCT
bptjm-46	212	2	insulin	insulin	NOUN
bptjm-46	212	3	e	e	NOUN
bptjm-46	212	4	�	�	NOUN
bptjm-46	212	5	ects	ect	VERB
bptjm-46	212	6	in	in	ADP
bptjm-46	212	7	muscle	muscle	NOUN
bptjm-46	212	8	and	and	CCONJ
bptjm-46	212	9	adipose	adipose	ADJ
bptjm-46	212	10	tissue	tissue	NOUN
bptjm-46	212	11	.	.	PUNCT
bptjm-46	212	12	”	"	PUNCT
bptjm-46	213	1	diabetes	diabetes	NOUN
bptjm-46	213	2	research	research	NOUN
bptjm-46	213	3	and	and	CCONJ
bptjm-46	213	4	clinical	clinical	ADJ
bptjm-46	213	5	practice	practice	NOUN
bptjm-46	213	6	vol	vol	NOUN
bptjm-46	213	7	.	.	PUNCT
bptjm-46	214	1	93	93	NUM
bptjm-46	214	2	suppl	suppl	ADJ
bptjm-46	214	3	1	1	NUM
bptjm-46	214	4	(	(	PUNCT
bptjm-46	214	5	2011	2011	NUM
bptjm-46	214	6	):	):	PUNCT
bptjm-46	214	7	s52	s52	NOUN
bptjm-46	214	8	-	-	PUNCT
bptjm-46	214	9	9	9	NUM
bptjm-46	214	10	.	.	PUNCT
bptjm-46	214	11	doi:10.1016	doi:10.1016	PROPN
bptjm-46	214	12	/	/	SYM
bptjm-46	214	13	s0168	s0168	PROPN
bptjm-46	214	14	-	-	PUNCT
bptjm-46	214	15	8227(11)70014	8227(11)70014	NUM
bptjm-46	214	16	-	-	PUNCT
bptjm-46	214	17	6	6	NUM
bptjm-46	214	18	8	8	NUM
bptjm-46	214	19	.	.	PUNCT
bptjm-46	214	20	forny	forny	PROPN
bptjm-46	214	21	-	-	PUNCT
bptjm-46	214	22	germano	germano	PROPN
bptjm-46	214	23	l	l	PROPN
bptjm-46	214	24	,	,	PUNCT
bptjm-46	214	25	de	de	X
bptjm-46	214	26	felice	felice	NOUN
bptjm-46	214	27	fg	fg	PROPN
bptjm-46	214	28	,	,	PUNCT
bptjm-46	214	29	vieira	vieira	PROPN
bptjm-46	214	30	mndn	mndn	NOUN
bptjm-46	214	31	.	.	PUNCT
bptjm-46	215	1	the	the	DET
bptjm-46	215	2	role	role	NOUN
bptjm-46	215	3	of	of	ADP
bptjm-46	215	4	leptin	leptin	NOUN
bptjm-46	215	5	and	and	CCONJ
bptjm-46	215	6	adiponectin	adiponectin	NOUN
bptjm-46	215	7	in	in	ADP
bptjm-46	215	8	obesity	obesity	NOUN
bptjm-46	215	9	-	-	PUNCT
bptjm-46	215	10	associated	associate	VERB
bptjm-46	215	11	cognitive	cognitive	ADJ
bptjm-46	215	12	decline	decline	NOUN
bptjm-46	215	13	and	and	CCONJ
bptjm-46	215	14	alzheimer	alzheimer	PROPN
bptjm-46	215	15	's	's	PART
bptjm-46	215	16	disease	disease	NOUN
bptjm-46	215	17	.	.	PUNCT
bptjm-46	216	1	front	front	ADJ
bptjm-46	216	2	neurosci	neurosci	PROPN
bptjm-46	216	3	.	.	PUNCT
bptjm-46	217	1	2019;12:1027	2019;12:1027	NUM
bptjm-46	217	2	.	.	PUNCT
bptjm-46	218	1	published	publish	VERB
bptjm-46	218	2	2019	2019	NUM
bptjm-46	218	3	jan	jan	PROPN
bptjm-46	218	4	14	14	NUM
bptjm-46	218	5	.	.	PUNCT
bptjm-46	219	1	doi:10.3389	doi:10.3389	PROPN
bptjm-46	219	2	/	/	SYM
bptjm-46	219	3	fnins.2018.01027	fnins.2018.01027	PROPN
bptjm-46	219	4	9	9	NUM
bptjm-46	219	5	.	.	PUNCT
bptjm-46	219	6	kennedy	kennedy	PROPN
bptjm-46	219	7	a	a	PROPN
bptjm-46	219	8	,	,	PUNCT
bptjm-46	219	9	gettys	gettys	PROPN
bptjm-46	219	10	tw	tw	PROPN
bptjm-46	219	11	,	,	PUNCT
bptjm-46	219	12	watson	watson	PROPN
bptjm-46	219	13	p	p	PROPN
bptjm-46	219	14	,	,	PUNCT
bptjm-46	219	15	et	et	PROPN
bptjm-46	219	16	al	al	PROPN
bptjm-46	219	17	.	.	PUNCT
bptjm-46	220	1	the	the	DET
bptjm-46	220	2	metabolic	metabolic	NOUN
bptjm-46	220	3	signi	signi	PROPN
bptjm-46	220	4	�	�	PROPN
bptjm-46	220	5	cance	cance	NOUN
bptjm-46	220	6	of	of	ADP
bptjm-46	220	7	leptin	leptin	NOUN
bptjm-46	220	8	in	in	ADP
bptjm-46	220	9	humans	human	NOUN
bptjm-46	220	10	:	:	PUNCT
bptjm-46	220	11	gender	gender	NOUN
bptjm-46	220	12	-	-	PUNCT
bptjm-46	220	13	based	base	VERB
bptjm-46	220	14	di	di	NOUN
bptjm-46	220	15	�	�	PROPN
bptjm-46	220	16	erences	erence	NOUN
bptjm-46	220	17	in	in	ADP
bptjm-46	220	18	relationship	relationship	NOUN
bptjm-46	220	19	to	to	ADP
bptjm-46	220	20	adiposity	adiposity	NOUN
bptjm-46	220	21	,	,	PUNCT
bptjm-46	220	22	insulin	insulin	NOUN
bptjm-46	220	23	sensitivity	sensitivity	NOUN
bptjm-46	220	24	,	,	PUNCT
bptjm-46	220	25	and	and	CCONJ
bptjm-46	220	26	energy	energy	NOUN
bptjm-46	220	27	expenditure	expenditure	NOUN
bptjm-46	220	28	.	.	PUNCT
bptjm-46	221	1	j	j	PROPN
bptjm-46	221	2	clin	clin	PROPN
bptjm-46	221	3	endocrinol	endocrinol	PROPN
bptjm-46	221	4	metab	metab	NOUN
bptjm-46	221	5	.	.	PUNCT
bptjm-46	222	1	1997;82(4):1293	1997;82(4):1293	NUM
bptjm-46	222	2	-	-	SYM
bptjm-46	222	3	1300	1300	NUM
bptjm-46	222	4	.	.	PUNCT
bptjm-46	223	1	doi:10.1210	doi:10.1210	PROPN
bptjm-46	223	2	/	/	SYM
bptjm-46	223	3	jcem.82.4.3859	jcem.82.4.3859	PROPN
bptjm-46	223	4	10	10	NUM
bptjm-46	223	5	.	.	PUNCT
bptjm-46	224	1	wang	wang	PROPN
bptjm-46	224	2	,	,	PUNCT
bptjm-46	224	3	guanyu	guanyu	PROPN
bptjm-46	224	4	.	.	PUNCT
bptjm-46	225	1	“	"	PUNCT
bptjm-46	225	2	singularity	singularity	NOUN
bptjm-46	225	3	analysis	analysis	NOUN
bptjm-46	225	4	of	of	ADP
bptjm-46	225	5	the	the	DET
bptjm-46	225	6	akt	akt	NOUN
bptjm-46	225	7	signaling	signal	VERB
bptjm-46	225	8	pathway	pathway	NOUN
bptjm-46	225	9	reveals	reveal	VERB
bptjm-46	225	10	connections	connection	NOUN
bptjm-46	225	11	between	between	ADP
bptjm-46	225	12	cancer	cancer	NOUN
bptjm-46	225	13	and	and	CCONJ
bptjm-46	225	14	metabolic	metabolic	NOUN
bptjm-46	225	15	diseases	disease	NOUN
bptjm-46	225	16	.	.	PUNCT
bptjm-46	225	17	”	"	PUNCT
bptjm-46	226	1	physical	physical	ADJ
bptjm-46	226	2	biology	biology	NOUN
bptjm-46	226	3	vol	vol	NOUN
bptjm-46	226	4	.	.	PUNCT
bptjm-46	226	5	7,4	7,4	NUM
bptjm-46	226	6	046015	046015	NUM
bptjm-46	226	7	.	.	PUNCT
bptjm-46	227	1	22	22	NUM
bptjm-46	227	2	dec	dec	PROPN
bptjm-46	227	3	.	.	PROPN
bptjm-46	227	4	2010	2010	NUM
bptjm-46	227	5	,	,	PUNCT
bptjm-46	227	6	doi:10.1088/1478	doi:10.1088/1478	NOUN
bptjm-46	227	7	-	-	SYM
bptjm-46	227	8	3975/7/4/046015	3975/7/4/046015	NUM
bptjm-46	227	9	11	11	NUM
bptjm-46	227	10	.	.	PUNCT
bptjm-46	228	1	gatenby	gatenby	PROPN
bptjm-46	228	2	,	,	PUNCT
bptjm-46	228	3	r.	r.	PROPN
bptjm-46	228	4	,	,	PUNCT
bptjm-46	228	5	gillies	gillie	NOUN
bptjm-46	228	6	,	,	PUNCT
bptjm-46	228	7	r.	r.	PROPN
bptjm-46	228	8	why	why	SCONJ
bptjm-46	228	9	do	do	AUX
bptjm-46	228	10	cancers	cancer	NOUN
bptjm-46	228	11	have	have	VERB
bptjm-46	228	12	high	high	ADJ
bptjm-46	228	13	aerobic	aerobic	ADJ
bptjm-46	228	14	glycolysis	glycolysis	NOUN
bptjm-46	228	15	?	?	PUNCT
bptjm-46	228	16	.	.	PUNCT
bptjm-46	229	1	nat	nat	PROPN
bptjm-46	229	2	rev	rev	VERB
bptjm-46	229	3	cancer	cancer	NOUN
bptjm-46	229	4	4	4	NUM
bptjm-46	229	5	,	,	PUNCT
bptjm-46	229	6	891–899	891–899	NUM
bptjm-46	229	7	(	(	PUNCT
bptjm-46	229	8	2004	2004	NUM
bptjm-46	229	9	)	)	PUNCT
bptjm-46	229	10	.	.	PUNCT
bptjm-46	230	1	https://doi.org/10.1038/nrc1478	https://doi.org/10.1038/nrc1478	PROPN
bptjm-46	230	2	12	12	NUM
bptjm-46	230	3	.	.	PUNCT
bptjm-46	231	1	del	del	PROPN
bptjm-46	231	2	puerto	puerto	PROPN
bptjm-46	231	3	-	-	PUNCT
bptjm-46	231	4	nevado	nevado	NOUN
bptjm-46	231	5	l	l	PROPN
bptjm-46	231	6	,	,	PUNCT
bptjm-46	231	7	santiago	santiago	PROPN
bptjm-46	231	8	-	-	PUNCT
bptjm-46	231	9	hernandez	hernandez	PROPN
bptjm-46	231	10	a	a	PROPN
bptjm-46	231	11	,	,	PUNCT
bptjm-46	231	12	solanes	solane	NOUN
bptjm-46	231	13	-	-	PUNCT
bptjm-46	231	14	casado	casado	NOUN
bptjm-46	231	15	s	s	PROPN
bptjm-46	231	16	,	,	PUNCT
bptjm-46	231	17	et	et	PROPN
bptjm-46	231	18	al	al	PROPN
bptjm-46	231	19	.	.	PUNCT
bptjm-46	231	20	diabetes	diabetes	NOUN
bptjm-46	231	21	-	-	PUNCT
bptjm-46	231	22	mediated	mediate	VERB
bptjm-46	231	23	promotion	promotion	NOUN
bptjm-46	231	24	of	of	ADP
bptjm-46	231	25	colon	colon	NOUN
bptjm-46	231	26	mucosa	mucosa	NOUN
bptjm-46	231	27	carcinogenesis	carcinogenesis	NOUN
bptjm-46	231	28	is	be	AUX
bptjm-46	231	29	associated	associate	VERB
bptjm-46	231	30	with	with	ADP
bptjm-46	231	31	mitochondrial	mitochondrial	ADJ
bptjm-46	231	32	dysfunction	dysfunction	NOUN
bptjm-46	231	33	.	.	PUNCT
bptjm-46	232	1	mol	mol	ADP
bptjm-46	232	2	oncol	oncol	ADJ
bptjm-46	232	3	.	.	PUNCT
bptjm-46	233	1	2019;13(9):1887	2019;13(9):1887	NUM
bptjm-46	233	2	-	-	SYM
bptjm-46	233	3	1897	1897	NUM
bptjm-46	233	4	.	.	PUNCT
bptjm-46	234	1	doi:10.1002/1878	doi:10.1002/1878	PROPN
bptjm-46	234	2	-	-	PUNCT
bptjm-46	234	3	0261.12531	0261.12531	PROPN
bptjm-46	234	4	13	13	NUM
bptjm-46	234	5	.	.	PUNCT
bptjm-46	235	1	zhang	zhang	PROPN
bptjm-46	235	2	,	,	PUNCT
bptjm-46	235	3	daoxiang	daoxiang	VERB
bptjm-46	235	4	et	et	PROPN
bptjm-46	235	5	al	al	PROPN
bptjm-46	235	6	.	.	PUNCT
bptjm-46	236	1	“	"	PUNCT
bptjm-46	236	2	metabolic	metabolic	NOUN
bptjm-46	236	3	reprogramming	reprogramming	NOUN
bptjm-46	236	4	of	of	ADP
bptjm-46	236	5	cancer	cancer	NOUN
bptjm-46	236	6	-	-	PUNCT
bptjm-46	236	7	associated	associate	VERB
bptjm-46	236	8	�	�	NOUN
bptjm-46	236	9	broblasts	broblast	NOUN
bptjm-46	236	10	by	by	ADP
bptjm-46	236	11	idh3α	idh3α	PROPN
bptjm-46	236	12	downregulation	downregulation	NOUN
bptjm-46	236	13	.	.	PUNCT
bptjm-46	236	14	”	"	PUNCT
bptjm-46	237	1	cell	cell	NOUN
bptjm-46	237	2	reports	report	NOUN
bptjm-46	237	3	vol	vol	NOUN
bptjm-46	237	4	.	.	PUNCT
bptjm-46	238	1	10,8	10,8	NUM
bptjm-46	238	2	(	(	PUNCT
bptjm-46	238	3	2015	2015	NUM
bptjm-46	238	4	):	):	PUNCT
bptjm-46	238	5	1335	1335	NUM
bptjm-46	238	6	-	-	SYM
bptjm-46	238	7	48	48	NUM
bptjm-46	238	8	.	.	PUNCT
bptjm-46	239	1	doi:10.1016	doi:10.1016	PROPN
bptjm-46	239	2	/	/	SYM
bptjm-46	239	3	j.celrep.2015.02.006	j.celrep.2015.02.006	PROPN
bptjm-46	239	4	14	14	NUM
bptjm-46	239	5	.	.	PUNCT
bptjm-46	240	1	neophytou	neophytou	PROPN
bptjm-46	240	2	cm	cm	PROPN
bptjm-46	240	3	,	,	PUNCT
bptjm-46	240	4	panagi	panagi	PROPN
bptjm-46	240	5	m	m	PROPN
bptjm-46	240	6	,	,	PUNCT
bptjm-46	240	7	stylianopoulos	stylianopoulos	PROPN
bptjm-46	240	8	t	t	PROPN
bptjm-46	240	9	,	,	PUNCT
bptjm-46	240	10	papageorgis	papageorgis	ADJ
bptjm-46	241	1	p.	p.	NOUN
bptjm-46	241	2	the	the	DET
bptjm-46	241	3	role	role	NOUN
bptjm-46	241	4	of	of	ADP
bptjm-46	241	5	tumor	tumor	NOUN
bptjm-46	241	6	microenvironment	microenvironment	NOUN
bptjm-46	241	7	in	in	ADP
bptjm-46	241	8	cancer	cancer	NOUN
bptjm-46	241	9	metastasis	metastasis	NOUN
bptjm-46	241	10	:	:	PUNCT
bptjm-46	241	11	molecular	molecular	ADJ
bptjm-46	241	12	mechanisms	mechanism	NOUN
bptjm-46	241	13	and	and	CCONJ
bptjm-46	241	14	therapeutic	therapeutic	ADJ
bptjm-46	241	15	berkeley	berkeley	PROPN
bptjm-46	241	16	pharma	pharma	PROPN
bptjm-46	241	17	tech	tech	NOUN
bptjm-46	241	18	journal	journal	NOUN
bptjm-46	241	19	of	of	ADP
bptjm-46	241	20	medicine	medicine	NOUN
bptjm-46	241	21	|	|	ADV
bptjm-46	241	22	115	115	NUM
bptjm-46	241	23	opportunities	opportunity	NOUN
bptjm-46	241	24	.	.	PUNCT
bptjm-46	242	1	cancers	cancer	NOUN
bptjm-46	242	2	(	(	PUNCT
bptjm-46	242	3	basel	basel	PROPN
bptjm-46	242	4	)	)	PUNCT
bptjm-46	242	5	.	.	PUNCT
bptjm-46	243	1	2021;13(9):2053	2021;13(9):2053	NUM
bptjm-46	243	2	.	.	PUNCT
bptjm-46	244	1	published	publish	VERB
bptjm-46	244	2	2021	2021	NUM
bptjm-46	244	3	apr	apr	NOUN
bptjm-46	244	4	23	23	NUM
bptjm-46	244	5	.	.	PUNCT
bptjm-46	245	1	doi:10.3390	doi:10.3390	NOUN
bptjm-46	245	2	/	/	SYM
bptjm-46	245	3	cancers13092053	cancers13092053	PROPN
bptjm-46	245	4	15	15	NUM
bptjm-46	245	5	.	.	PUNCT
bptjm-46	246	1	vander	vander	PROPN
bptjm-46	246	2	heiden	heiden	PROPN
bptjm-46	246	3	,	,	PUNCT
bptjm-46	246	4	matthew	matthew	PROPN
bptjm-46	246	5	g	g	PROPN
bptjm-46	246	6	et	et	PROPN
bptjm-46	246	7	al	al	PROPN
bptjm-46	246	8	.	.	PUNCT
bptjm-46	247	1	“	"	PUNCT
bptjm-46	247	2	understanding	understand	VERB
bptjm-46	247	3	thewarburg	thewarburg	NOUN
bptjm-46	247	4	e	e	NOUN
bptjm-46	247	5	�	�	PROPN
bptjm-46	247	6	ect	ect	VERB
bptjm-46	247	7	:	:	PUNCT
bptjm-46	247	8	the	the	DET
bptjm-46	247	9	metabolic	metabolic	NOUN
bptjm-46	247	10	requirements	requirement	NOUN
bptjm-46	247	11	of	of	ADP
bptjm-46	247	12	cell	cell	NOUN
bptjm-46	247	13	proliferation	proliferation	NOUN
bptjm-46	247	14	.	.	PUNCT
bptjm-46	247	15	”	"	PUNCT
bptjm-46	248	1	science	science	NOUN
bptjm-46	248	2	(	(	PUNCT
bptjm-46	248	3	new	new	PROPN
bptjm-46	248	4	york	york	PROPN
bptjm-46	248	5	,	,	PUNCT
bptjm-46	248	6	n.y	n.y	PROPN
bptjm-46	248	7	.	.	PROPN
bptjm-46	248	8	)	)	PUNCT
bptjm-46	248	9	vol	vol	NOUN
bptjm-46	248	10	.	.	PUNCT
bptjm-46	249	1	324,5930	324,5930	NUM
bptjm-46	249	2	(	(	PUNCT
bptjm-46	249	3	2009	2009	NUM
bptjm-46	249	4	):	):	PUNCT
bptjm-46	249	5	1029	1029	NUM
bptjm-46	249	6	-	-	SYM
bptjm-46	249	7	33	33	NUM
bptjm-46	249	8	.	.	PUNCT
bptjm-46	249	9	doi:10.1126	doi:10.1126	PROPN
bptjm-46	249	10	/	/	SYM
bptjm-46	250	1	science.1160809	science.1160809	PROPN
bptjm-46	250	2	16	16	NUM
bptjm-46	250	3	.	.	PUNCT
bptjm-46	251	1	jogie	jogie	NOUN
bptjm-46	251	2	-	-	PUNCT
bptjm-46	251	3	brahim	brahim	PROPN
bptjm-46	251	4	,	,	PUNCT
bptjm-46	251	5	sherryline	sherryline	NOUN
bptjm-46	251	6	et	et	PROPN
bptjm-46	251	7	al	al	PROPN
bptjm-46	251	8	.	.	PUNCT
bptjm-46	252	1	“	"	PUNCT
bptjm-46	252	2	unraveling	unravel	VERB
bptjm-46	252	3	insulin	insulin	NOUN
bptjm-46	252	4	-	-	PUNCT
bptjm-46	252	5	like	like	ADJ
bptjm-46	252	6	growth	growth	NOUN
bptjm-46	252	7	factor	factor	NOUN
bptjm-46	252	8	binding	bind	VERB
bptjm-46	252	9	protein-3	protein-3	PROPN
bptjm-46	252	10	actions	action	NOUN
bptjm-46	252	11	in	in	ADP
bptjm-46	252	12	human	human	ADJ
bptjm-46	252	13	disease	disease	NOUN
bptjm-46	252	14	.	.	PUNCT
bptjm-46	252	15	”	"	PUNCT
bptjm-46	253	1	endocrine	endocrine	ADJ
bptjm-46	253	2	reviews	review	NOUN
bptjm-46	253	3	vol	vol	NOUN
bptjm-46	253	4	.	.	PUNCT
bptjm-46	254	1	30,5	30,5	NUM
bptjm-46	254	2	(	(	PUNCT
bptjm-46	254	3	2009	2009	NUM
bptjm-46	254	4	):	):	PUNCT
bptjm-46	254	5	417	417	NUM
bptjm-46	254	6	-	-	SYM
bptjm-46	254	7	37	37	NUM
bptjm-46	254	8	.	.	PUNCT
bptjm-46	255	1	doi:10.1210	doi:10.1210	PROPN
bptjm-46	255	2	/	/	SYM
bptjm-46	255	3	er.2008	er.2008	NOUN
bptjm-46	255	4	-	-	NOUN
bptjm-46	255	5	0028	0028	NUM
bptjm-46	255	6	17	17	NUM
bptjm-46	255	7	.	.	PUNCT
bptjm-46	256	1	olson	olson	PROPN
bptjm-46	256	2	,	,	PUNCT
bptjm-46	256	3	a	a	DET
bptjm-46	256	4	l	l	NOUN
bptjm-46	256	5	,	,	PUNCT
bptjm-46	256	6	and	and	CCONJ
bptjm-46	256	7	j	j	PROPN
bptjm-46	256	8	e	e	PROPN
bptjm-46	256	9	pessin	pessin	PROPN
bptjm-46	256	10	.	.	PUNCT
bptjm-46	257	1	“	"	PUNCT
bptjm-46	257	2	structure	structure	NOUN
bptjm-46	257	3	,	,	PUNCT
bptjm-46	257	4	function	function	NOUN
bptjm-46	257	5	,	,	PUNCT
bptjm-46	257	6	and	and	CCONJ
bptjm-46	257	7	regulation	regulation	NOUN
bptjm-46	257	8	of	of	ADP
bptjm-46	257	9	the	the	DET
bptjm-46	257	10	mammalian	mammalian	ADJ
bptjm-46	257	11	facilitative	facilitative	ADJ
bptjm-46	257	12	glucose	glucose	NOUN
bptjm-46	257	13	transporter	transporter	NOUN
bptjm-46	257	14	gene	gene	NOUN
bptjm-46	257	15	family	family	NOUN
bptjm-46	257	16	.	.	PUNCT
bptjm-46	257	17	”	"	PUNCT
bptjm-46	258	1	annual	annual	ADJ
bptjm-46	258	2	review	review	NOUN
bptjm-46	258	3	of	of	ADP
bptjm-46	258	4	nutrition	nutrition	NOUN
bptjm-46	258	5	vol	vol	NOUN
bptjm-46	258	6	.	.	PUNCT
bptjm-46	259	1	16	16	NUM
bptjm-46	259	2	(	(	PUNCT
bptjm-46	259	3	1996	1996	NUM
bptjm-46	259	4	):	):	PUNCT
bptjm-46	259	5	235	235	NUM
bptjm-46	259	6	-	-	SYM
bptjm-46	259	7	56	56	NUM
bptjm-46	259	8	.	.	PUNCT
bptjm-46	260	1	doi:10.1146	doi:10.1146	NOUN
bptjm-46	260	2	/	/	SYM
bptjm-46	260	3	annurev.nu.16.070196.001315	annurev.nu.16.070196.001315	PROPN
bptjm-46	260	4	18	18	NUM
bptjm-46	260	5	.	.	PUNCT
bptjm-46	261	1	call	call	NOUN
bptjm-46	261	2	r	r	NOUN
bptjm-46	261	3	,	,	PUNCT
bptjm-46	261	4	grimsley	grimsley	PROPN
bptjm-46	261	5	m	m	PROPN
bptjm-46	261	6	,	,	PUNCT
bptjm-46	261	7	cadwallader	cadwallader	NOUN
bptjm-46	261	8	l	l	PROPN
bptjm-46	261	9	,	,	PUNCT
bptjm-46	261	10	et	et	PROPN
bptjm-46	261	11	al	al	PROPN
bptjm-46	261	12	.	.	PUNCT
bptjm-46	261	13	insulin	insulin	PROPN
bptjm-46	261	14	--	--	PUNCT
bptjm-46	261	15	carcinogen	carcinogen	NOUN
bptjm-46	261	16	or	or	CCONJ
bptjm-46	261	17	mitogen	mitogen	PROPN
bptjm-46	261	18	?	?	PUNCT
bptjm-46	262	1	preclinical	preclinical	ADJ
bptjm-46	262	2	and	and	CCONJ
bptjm-46	262	3	clinical	clinical	ADJ
bptjm-46	262	4	evidence	evidence	NOUN
bptjm-46	262	5	from	from	ADP
bptjm-46	262	6	prostate	prostate	NOUN
bptjm-46	262	7	,	,	PUNCT
bptjm-46	262	8	breast	breast	NOUN
bptjm-46	262	9	,	,	PUNCT
bptjm-46	262	10	pancreatic	pancreatic	NOUN
bptjm-46	262	11	,	,	PUNCT
bptjm-46	262	12	and	and	CCONJ
bptjm-46	262	13	colorectal	colorectal	ADJ
bptjm-46	262	14	cancer	cancer	NOUN
bptjm-46	262	15	research	research	NOUN
bptjm-46	262	16	.	.	PUNCT
bptjm-46	263	1	postgradmed	postgradme	VERB
bptjm-46	263	2	.	.	PUNCT
bptjm-46	264	1	2010;122(3):158	2010;122(3):158	NUM
bptjm-46	264	2	-	-	SYM
bptjm-46	264	3	165	165	NUM
bptjm-46	264	4	.	.	PUNCT
bptjm-46	264	5	doi:10.3810	doi:10.3810	PROPN
bptjm-46	264	6	/	/	SYM
bptjm-46	264	7	pgm.2010.05.2153	pgm.2010.05.2153	VERB
bptjm-46	264	8	19	19	NUM
bptjm-46	264	9	.	.	PUNCT
bptjm-46	265	1	bell	bell	PROPN
bptjm-46	265	2	,	,	PUNCT
bptjm-46	265	3	g	g	PROPN
bptjm-46	265	4	i	i	INTJ
bptjm-46	265	5	et	et	PROPN
bptjm-46	265	6	al	al	PROPN
bptjm-46	265	7	.	.	PUNCT
bptjm-46	266	1	“	"	PUNCT
bptjm-46	266	2	molecular	molecular	ADJ
bptjm-46	266	3	biology	biology	NOUN
bptjm-46	266	4	of	of	ADP
bptjm-46	266	5	mammalian	mammalian	ADJ
bptjm-46	266	6	glucose	glucose	NOUN
bptjm-46	266	7	transporters	transporter	NOUN
bptjm-46	266	8	.	.	PUNCT
bptjm-46	266	9	”	"	PUNCT
bptjm-46	267	1	diabetes	diabetes	NOUN
bptjm-46	267	2	care	care	NOUN
bptjm-46	267	3	vol	vol	NOUN
bptjm-46	267	4	.	.	PUNCT
bptjm-46	268	1	13,3	13,3	NUM
bptjm-46	268	2	(	(	PUNCT
bptjm-46	268	3	1990	1990	NUM
bptjm-46	268	4	):	):	PUNCT
bptjm-46	268	5	198	198	NUM
bptjm-46	268	6	-	-	SYM
bptjm-46	268	7	208	208	NUM
bptjm-46	268	8	.	.	PUNCT
bptjm-46	269	1	doi:10.2337	doi:10.2337	NOUN
bptjm-46	269	2	/	/	SYM
bptjm-46	269	3	diacare.13.3.198	diacare.13.3.198	NUM
bptjm-46	269	4	20	20	NUM
bptjm-46	269	5	.	.	PUNCT
bptjm-46	269	6	shepherd	shepherd	NOUN
bptjm-46	269	7	,	,	PUNCT
bptjm-46	269	8	p	p	NOUN
bptjm-46	269	9	r	r	NOUN
bptjm-46	269	10	et	et	NOUN
bptjm-46	269	11	al	al	PROPN
bptjm-46	269	12	.	.	PUNCT
bptjm-46	270	1	“	"	PUNCT
bptjm-46	270	2	adipose	adipose	ADP
bptjm-46	270	3	cell	cell	NOUN
bptjm-46	270	4	hyperplasia	hyperplasia	NOUN
bptjm-46	270	5	and	and	CCONJ
bptjm-46	270	6	enhanced	enhance	VERB
bptjm-46	270	7	glucose	glucose	NOUN
bptjm-46	270	8	disposal	disposal	NOUN
bptjm-46	270	9	in	in	ADP
bptjm-46	270	10	transgenic	transgenic	NOUN
bptjm-46	270	11	mice	mouse	NOUN
bptjm-46	270	12	overexpressing	overexpresse	VERB
bptjm-46	270	13	glut4	glut4	NOUN
bptjm-46	270	14	selectively	selectively	ADV
bptjm-46	270	15	in	in	ADP
bptjm-46	270	16	adipose	adipose	ADJ
bptjm-46	270	17	tissue	tissue	NOUN
bptjm-46	270	18	.	.	PUNCT
bptjm-46	270	19	”	"	PUNCT
bptjm-46	271	1	the	the	DET
bptjm-46	271	2	journal	journal	NOUN
bptjm-46	271	3	of	of	ADP
bptjm-46	271	4	biological	biological	ADJ
bptjm-46	271	5	chemistry	chemistry	NOUN
bptjm-46	271	6	vol	vol	NOUN
bptjm-46	271	7	.	.	PUNCT
bptjm-46	271	8	268,30	268,30	NUM
bptjm-46	271	9	(	(	PUNCT
bptjm-46	271	10	1993	1993	NUM
bptjm-46	271	11	):	):	PUNCT
bptjm-46	271	12	22243	22243	NUM
bptjm-46	271	13	-	-	SYM
bptjm-46	271	14	6	6	NUM
bptjm-46	271	15	.	.	NUM
bptjm-46	271	16	21	21	NUM
bptjm-46	271	17	.	.	PUNCT
bptjm-46	272	1	favaretto	favaretto	PROPN
bptjm-46	272	2	,	,	PUNCT
bptjm-46	272	3	francesca	francesca	PROPN
bptjm-46	272	4	et	et	PROPN
bptjm-46	272	5	al	al	PROPN
bptjm-46	272	6	.	.	PUNCT
bptjm-46	273	1	“	"	PUNCT
bptjm-46	273	2	glut4	glut4	PRON
bptjm-46	273	3	defects	defect	NOUN
bptjm-46	273	4	in	in	ADP
bptjm-46	273	5	adipose	adipose	ADJ
bptjm-46	273	6	tissue	tissue	NOUN
bptjm-46	273	7	are	be	AUX
bptjm-46	273	8	early	early	ADJ
bptjm-46	273	9	signs	sign	NOUN
bptjm-46	273	10	of	of	ADP
bptjm-46	273	11	metabolic	metabolic	NOUN
bptjm-46	273	12	alterations	alteration	NOUN
bptjm-46	273	13	in	in	ADP
bptjm-46	273	14	alms1gt	alms1gt	PROPN
bptjm-46	273	15	/	/	SYM
bptjm-46	273	16	gt	gt	PROPN
bptjm-46	273	17	,	,	PUNCT
bptjm-46	273	18	a	a	DET
bptjm-46	273	19	mouse	mouse	NOUN
bptjm-46	273	20	model	model	NOUN
bptjm-46	273	21	for	for	ADP
bptjm-46	273	22	obesity	obesity	NOUN
bptjm-46	273	23	and	and	CCONJ
bptjm-46	273	24	insulin	insulin	NOUN
bptjm-46	273	25	resistance	resistance	NOUN
bptjm-46	273	26	.	.	PUNCT
bptjm-46	273	27	”	"	PUNCT
bptjm-46	274	1	plos	plos	PROPN
bptjm-46	274	2	one	one	NUM
bptjm-46	274	3	vol	vol	NOUN
bptjm-46	274	4	.	.	PUNCT
bptjm-46	275	1	9,10	9,10	NUM
bptjm-46	275	2	e109540	e109540	PROPN
bptjm-46	275	3	.	.	PROPN
bptjm-46	275	4	9	9	NUM
bptjm-46	275	5	oct	oct	PROPN
bptjm-46	275	6	.	.	PROPN
bptjm-46	275	7	2014	2014	NUM
bptjm-46	275	8	,	,	PUNCT
bptjm-46	275	9	doi:10.1371	doi:10.1371	NOUN
bptjm-46	275	10	/	/	SYM
bptjm-46	275	11	journal.pone.0109540	journal.pone.0109540	PROPN
bptjm-46	275	12	22	22	NUM
bptjm-46	275	13	.	.	PUNCT
bptjm-46	276	1	hubbard	hubbard	PROPN
bptjm-46	276	2	,	,	PUNCT
bptjm-46	276	3	s	s	PART
bptjm-46	276	4	r	r	NOUN
bptjm-46	276	5	,	,	PUNCT
bptjm-46	276	6	and	and	CCONJ
bptjm-46	276	7	j	j	PROPN
bptjm-46	276	8	h	h	PROPN
bptjm-46	276	9	till	till	PROPN
bptjm-46	276	10	.	.	PUNCT
bptjm-46	277	1	“	"	PUNCT
bptjm-46	277	2	protein	protein	NOUN
bptjm-46	277	3	tyrosine	tyrosine	NOUN
bptjm-46	277	4	kinase	kinase	PROPN
bptjm-46	277	5	structure	structure	NOUN
bptjm-46	277	6	and	and	CCONJ
bptjm-46	277	7	function	function	NOUN
bptjm-46	277	8	.	.	PUNCT
bptjm-46	277	9	”	"	PUNCT
bptjm-46	278	1	annual	annual	ADJ
bptjm-46	278	2	review	review	NOUN
bptjm-46	278	3	of	of	ADP
bptjm-46	278	4	biochemistry	biochemistry	NOUN
bptjm-46	278	5	vol	vol	NOUN
bptjm-46	278	6	.	.	PUNCT
bptjm-46	279	1	69	69	NUM
bptjm-46	279	2	(	(	PUNCT
bptjm-46	279	3	2000	2000	NUM
bptjm-46	279	4	):	):	PUNCT
bptjm-46	279	5	373	373	NUM
bptjm-46	279	6	-	-	SYM
bptjm-46	279	7	98	98	NUM
bptjm-46	279	8	.	.	PUNCT
bptjm-46	280	1	doi:10.1146	doi:10.1146	NOUN
bptjm-46	280	2	/	/	SYM
bptjm-46	280	3	annurev.biochem.69.1.373	annurev.biochem.69.1.373	PROPN
bptjm-46	280	4	23	23	NUM
bptjm-46	280	5	.	.	PUNCT
bptjm-46	281	1	lemmon	lemmon	PROPN
bptjm-46	281	2	,	,	PUNCT
bptjm-46	281	3	mark	mark	VERB
bptjm-46	281	4	a	a	PRON
bptjm-46	281	5	,	,	PUNCT
bptjm-46	281	6	and	and	CCONJ
bptjm-46	281	7	joseph	joseph	PROPN
bptjm-46	281	8	schlessinger	schlessinger	PROPN
bptjm-46	281	9	.	.	PUNCT
bptjm-46	282	1	“	"	PUNCT
bptjm-46	282	2	cell	cell	NOUN
bptjm-46	282	3	signaling	signal	VERB
bptjm-46	282	4	by	by	ADP
bptjm-46	282	5	receptor	receptor	NOUN
bptjm-46	282	6	tyrosine	tyrosine	NOUN
bptjm-46	282	7	kinases	kinase	NOUN
bptjm-46	282	8	.	.	PUNCT
bptjm-46	282	9	”	"	PUNCT
bptjm-46	282	10	cell	cell	NOUN
bptjm-46	282	11	vol	vol	NOUN
bptjm-46	282	12	.	.	PUNCT
bptjm-46	283	1	141,7	141,7	NOUN
bptjm-46	283	2	(	(	PUNCT
bptjm-46	283	3	2010	2010	NUM
bptjm-46	283	4	):	):	PUNCT
bptjm-46	283	5	1117	1117	NUM
bptjm-46	283	6	-	-	SYM
bptjm-46	283	7	34	34	NUM
bptjm-46	283	8	.	.	PUNCT
bptjm-46	283	9	doi:10.1016	doi:10.1016	PROPN
bptjm-46	283	10	/	/	SYM
bptjm-46	283	11	j.cell.2010.06.011	j.cell.2010.06.011	PROPN
bptjm-46	283	12	24	24	NUM
bptjm-46	283	13	.	.	PUNCT
bptjm-46	284	1	fda	fda	PROPN
bptjm-46	284	2	fact	fact	PROPN
bptjm-46	284	3	sheet	sheet	NOUN
bptjm-46	284	4	,	,	PUNCT
bptjm-46	284	5	panitumumab	panitumumab	NOUN
bptjm-46	284	6	use	use	NOUN
bptjm-46	284	7	.	.	PUNCT
bptjm-46	285	1	https://www.accessdata.fda.gov/drugsatfda_docs/	https://www.accessdata.fda.gov/drugsatfda_docs/	PROPN
bptjm-46	285	2	label/2009/125147s080lbl.pdf	label/2009/125147s080lbl.pdf	PROPN
bptjm-46	285	3	25	25	NUM
bptjm-46	285	4	.	.	PUNCT
bptjm-46	286	1	zhen	zhen	PROPN
bptjm-46	286	2	,	,	PUNCT
bptjm-46	286	3	y	y	PROPN
bptjm-46	286	4	et	et	PROPN
bptjm-46	286	5	al	al	PROPN
bptjm-46	286	6	.	.	PUNCT
bptjm-46	287	1	“	"	PUNCT
bptjm-46	287	2	knockdown	knockdown	NOUN
bptjm-46	287	3	of	of	ADP
bptjm-46	287	4	egfr	egfr	NOUN
bptjm-46	287	5	inhibits	inhibit	VERB
bptjm-46	287	6	growth	growth	NOUN
bptjm-46	287	7	and	and	CCONJ
bptjm-46	287	8	invasion	invasion	NOUN
bptjm-46	287	9	of	of	ADP
bptjm-46	287	10	gastric	gastric	ADJ
bptjm-46	287	11	cancer	cancer	NOUN
bptjm-46	287	12	cells	cell	NOUN
bptjm-46	287	13	.	.	PUNCT
bptjm-46	287	14	”	"	PUNCT
bptjm-46	288	1	cancer	cancer	NOUN
bptjm-46	288	2	gene	gene	NOUN
bptjm-46	288	3	therapy	therapy	NOUN
bptjm-46	288	4	vol	vol	NOUN
bptjm-46	288	5	.	.	PUNCT
bptjm-46	289	1	21,11	21,11	NUM
bptjm-46	289	2	(	(	PUNCT
bptjm-46	289	3	2014	2014	NUM
bptjm-46	289	4	):	):	PUNCT
bptjm-46	289	5	491	491	NUM
bptjm-46	289	6	-	-	SYM
bptjm-46	289	7	7	7	NUM
bptjm-46	289	8	.	.	PUNCT
bptjm-46	289	9	doi:10.1038	doi:10.1038	NOUN
bptjm-46	289	10	/	/	SYM
bptjm-46	289	11	cgt.2014.55	cgt.2014.55	PROPN
bptjm-46	289	12	26	26	NUM
bptjm-46	289	13	.	.	PUNCT
bptjm-46	290	1	clinicaltrial.gov	clinicaltrial.gov	X
bptjm-46	290	2	,	,	PUNCT
bptjm-46	290	3	searching	search	VERB
bptjm-46	290	4	criteria	criterion	NOUN
bptjm-46	290	5	panitumumab	panitumumab	NOUN
bptjm-46	290	6	.	.	PUNCT
bptjm-46	291	1	https://www.clinicaltrials.gov/ct2/results?cond=p	https://www.clinicaltrials.gov/ct2/results?cond=p	PROPN
bptjm-46	291	2	anitumumab&term=&cntry	anitumumab&term=&cntry	PROPN
bptjm-46	291	3	=	=	SYM
bptjm-46	291	4	us&state=&city=	us&state=&city=	PROPN
bptjm-46	291	5	&	&	CCONJ
bptjm-46	291	6	dist=&search	dist=&search	NOUN
bptjm-46	291	7	=	=	NOUN
bptjm-46	291	8	search	search	NOUN
bptjm-46	291	9	27	27	NUM
bptjm-46	291	10	.	.	PUNCT
bptjm-46	292	1	ocaña	ocaña	PROPN
bptjm-46	292	2	,	,	PUNCT
bptjm-46	292	3	mª	mª	PROPN
bptjm-46	292	4	carmen	carman	NOUN
bptjm-46	292	5	et	et	PROPN
bptjm-46	292	6	al	al	PROPN
bptjm-46	292	7	.	.	PUNCT
bptjm-46	293	1	“	"	PUNCT
bptjm-46	293	2	fasentin	fasentin	NOUN
bptjm-46	293	3	diminishes	diminish	VERB
bptjm-46	293	4	endothelial	endothelial	ADJ
bptjm-46	293	5	cell	cell	NOUN
bptjm-46	293	6	proliferation	proliferation	NOUN
bptjm-46	293	7	,	,	PUNCT
bptjm-46	293	8	di	di	NOUN
bptjm-46	293	9	�	�	PROPN
bptjm-46	293	10	erentiation	erentiation	NOUN
bptjm-46	293	11	and	and	CCONJ
bptjm-46	293	12	invasion	invasion	NOUN
bptjm-46	293	13	in	in	ADP
bptjm-46	293	14	a	a	DET
bptjm-46	293	15	glucose	glucose	NOUN
bptjm-46	293	16	metabolism	metabolism	NOUN
bptjm-46	293	17	-	-	PUNCT
bptjm-46	293	18	independent	independent	ADJ
bptjm-46	293	19	manner	manner	NOUN
bptjm-46	293	20	.	.	PUNCT
bptjm-46	293	21	”	"	PUNCT
bptjm-46	294	1	scienti	scienti	X
bptjm-46	294	2	�	�	PROPN
bptjm-46	294	3	c	c	PROPN
bptjm-46	294	4	reports	report	NOUN
bptjm-46	294	5	vol	vol	NOUN
bptjm-46	294	6	.	.	PUNCT
bptjm-46	295	1	10,1	10,1	NUM
bptjm-46	295	2	6132	6132	NUM
bptjm-46	295	3	.	.	PUNCT
bptjm-46	296	1	9	9	NUM
bptjm-46	296	2	apr	apr	NOUN
bptjm-46	296	3	.	.	PUNCT
bptjm-46	296	4	2020	2020	NUM
bptjm-46	296	5	,	,	PUNCT
bptjm-46	296	6	doi:10.1038	doi:10.1038	NOUN
bptjm-46	296	7	/	/	SYM
bptjm-46	296	8	s41598	s41598	NOUN
bptjm-46	296	9	-	-	PUNCT
bptjm-46	296	10	020	020	NUM
bptjm-46	296	11	-	-	PUNCT
bptjm-46	296	12	63232	63232	NUM
bptjm-46	296	13	-	-	PUNCT
bptjm-46	296	14	z	z	NOUN
bptjm-46	296	15	28	28	NUM
bptjm-46	296	16	.	.	PUNCT
bptjm-46	297	1	chou	chou	NOUN
bptjm-46	297	2	,	,	PUNCT
bptjm-46	297	3	ping‐chieh	ping‐chieh	PROPN
bptjm-46	297	4	,	,	PUNCT
bptjm-46	297	5	et	et	PROPN
bptjm-46	297	6	al	al	PROPN
bptjm-46	297	7	.	.	PUNCT
bptjm-46	298	1	“	"	PUNCT
bptjm-46	298	2	impact	impact	NOUN
bptjm-46	298	3	of	of	ADP
bptjm-46	298	4	diabetes	diabetes	NOUN
bptjm-46	298	5	on	on	ADP
bptjm-46	298	6	promoting	promote	VERB
bptjm-46	298	7	the	the	DET
bptjm-46	298	8	growth	growth	NOUN
bptjm-46	298	9	of	of	ADP
bptjm-46	298	10	breast	breast	NOUN
bptjm-46	298	11	cancer	cancer	NOUN
bptjm-46	298	12	.	.	PUNCT
bptjm-46	298	13	”	"	PUNCT
bptjm-46	299	1	cancer	cancer	NOUN
bptjm-46	299	2	communications	communication	NOUN
bptjm-46	299	3	,	,	PUNCT
bptjm-46	299	4	vol	vol	NOUN
bptjm-46	299	5	.	.	PROPN
bptjm-46	299	6	41	41	NUM
bptjm-46	299	7	,	,	PUNCT
bptjm-46	299	8	no	no	INTJ
bptjm-46	299	9	.	.	NOUN
bptjm-46	299	10	5	5	NUM
bptjm-46	299	11	,	,	PUNCT
bptjm-46	299	12	2021	2021	NUM
bptjm-46	299	13	,	,	PUNCT
bptjm-46	299	14	doi:10.1002	doi:10.1002	NOUN
bptjm-46	299	15	/	/	SYM
bptjm-46	299	16	cac2.12147	cac2.12147	PROPN
bptjm-46	299	17	.	.	PUNCT
bptjm-46	300	1	doi	doi	PROPN
bptjm-46	300	2	:	:	PUNCT
bptjm-46	300	3	https://doi.org/10.1016	https://doi.org/10.1016	PROPN
bptjm-46	300	4	/	/	SYM
bptjm-46	300	5	j.ejphar.2018.11.028	j.ejphar.2018.11.028	PROPN
bptjm-46	300	6	berkeley	berkeley	PROPN
bptjm-46	300	7	pharma	pharma	PROPN
bptjm-46	300	8	tech	tech	NOUN
bptjm-46	300	9	journal	journal	NOUN
bptjm-46	300	10	of	of	ADP
bptjm-46	300	11	medicine	medicine	NOUN
bptjm-46	300	12	|	|	ADV
bptjm-46	300	13	116	116	NUM
bptjm-46	300	14	29	29	NUM
bptjm-46	300	15	.	.	PUNCT
bptjm-46	301	1	kraus	kraus	PROPN
bptjm-46	301	2	d	d	PROPN
bptjm-46	301	3	,	,	PUNCT
bptjm-46	301	4	reckenbeil	reckenbeil	PROPN
bptjm-46	301	5	j	j	PROPN
bptjm-46	301	6	,	,	PUNCT
bptjm-46	301	7	veit	veit	PROPN
bptjm-46	301	8	n	n	CCONJ
bptjm-46	301	9	,	,	PUNCT
bptjm-46	301	10	et	et	PROPN
bptjm-46	301	11	al	al	PROPN
bptjm-46	301	12	.	.	PUNCT
bptjm-46	302	1	targeting	target	VERB
bptjm-46	302	2	glucose	glucose	NOUN
bptjm-46	302	3	transport	transport	NOUN
bptjm-46	302	4	and	and	CCONJ
bptjm-46	302	5	the	the	DET
bptjm-46	302	6	nad	nad	ADJ
bptjm-46	302	7	pathway	pathway	NOUN
bptjm-46	302	8	in	in	ADP
bptjm-46	302	9	tumor	tumor	NOUN
bptjm-46	302	10	cells	cell	NOUN
bptjm-46	302	11	with	with	ADP
bptjm-46	302	12	stf-31	stf-31	NOUN
bptjm-46	302	13	:	:	PUNCT
bptjm-46	302	14	a	a	DET
bptjm-46	302	15	re	re	NOUN
bptjm-46	302	16	-	-	NOUN
bptjm-46	302	17	evaluation	evaluation	NOUN
bptjm-46	302	18	.	.	PUNCT
bptjm-46	303	1	cell	cell	NOUN
bptjm-46	303	2	oncol	oncol	ADJ
bptjm-46	303	3	(	(	PUNCT
bptjm-46	303	4	dordr	dordr	ADV
bptjm-46	303	5	)	)	PUNCT
bptjm-46	303	6	.	.	PUNCT
bptjm-46	304	1	2018;41(5):485	2018;41(5):485	NUM
bptjm-46	304	2	-	-	SYM
bptjm-46	304	3	494	494	NUM
bptjm-46	304	4	.	.	PUNCT
bptjm-46	305	1	doi:10.1007	doi:10.1007	PROPN
bptjm-46	305	2	/	/	SYM
bptjm-46	305	3	s13402	s13402	PROPN
bptjm-46	305	4	-	-	PUNCT
bptjm-46	305	5	018	018	NUM
bptjm-46	305	6	-	-	PUNCT
bptjm-46	305	7	0385	0385	NUM
bptjm-46	305	8	-	-	SYM
bptjm-46	305	9	5	5	NUM
bptjm-46	305	10	30	30	NUM
bptjm-46	305	11	.	.	PUNCT
bptjm-46	306	1	wood	wood	NOUN
bptjm-46	306	2	te	te	PROPN
bptjm-46	306	3	,	,	PUNCT
bptjm-46	306	4	dalili	dalili	PROPN
bptjm-46	306	5	s	s	PROPN
bptjm-46	306	6	,	,	PUNCT
bptjm-46	306	7	simpson	simpson	PROPN
bptjm-46	306	8	cd	cd	PROPN
bptjm-46	306	9	,	,	PUNCT
bptjm-46	306	10	et	et	PROPN
bptjm-46	306	11	al	al	PROPN
bptjm-46	306	12	.	.	PUNCT
bptjm-46	307	1	a	a	DET
bptjm-46	307	2	novel	novel	ADJ
bptjm-46	307	3	inhibitor	inhibitor	NOUN
bptjm-46	307	4	of	of	ADP
bptjm-46	307	5	glucose	glucose	NOUN
bptjm-46	307	6	uptake	uptake	ADJ
bptjm-46	307	7	sensitizes	sensitize	VERB
bptjm-46	307	8	cells	cell	NOUN
bptjm-46	307	9	to	to	ADP
bptjm-46	307	10	fas	fas	ADJ
bptjm-46	307	11	-	-	ADJ
bptjm-46	307	12	induced	induce	VERB
bptjm-46	307	13	cell	cell	NOUN
bptjm-46	307	14	death	death	NOUN
bptjm-46	307	15	.	.	PUNCT
bptjm-46	308	1	mol	mol	ADP
bptjm-46	308	2	cancer	cancer	NOUN
bptjm-46	308	3	ther	ther	ADV
bptjm-46	308	4	.	.	PUNCT
bptjm-46	309	1	2008;7(11):3546	2008;7(11):3546	NUM
bptjm-46	309	2	-	-	SYM
bptjm-46	309	3	3555	3555	NUM
bptjm-46	309	4	.	.	PUNCT
bptjm-46	310	1	doi:10.1158/1535	doi:10.1158/1535	NOUN
bptjm-46	310	2	-	-	PUNCT
bptjm-46	310	3	7163.mct-08	7163.mct-08	NOUN
bptjm-46	310	4	-	-	SYM
bptjm-46	310	5	0569	0569	NUM
bptjm-46	310	6	31	31	NUM
bptjm-46	310	7	.	.	PUNCT
bptjm-46	311	1	zakikhani	zakikhani	NOUN
bptjm-46	311	2	,	,	PUNCT
bptjm-46	311	3	mahvash	mahvash	NOUN
bptjm-46	311	4	,	,	PUNCT
bptjm-46	311	5	et	et	PROPN
bptjm-46	311	6	al	al	PROPN
bptjm-46	311	7	.	.	PUNCT
bptjm-46	312	1	“	"	PUNCT
bptjm-46	312	2	metformin	metformin	NOUN
bptjm-46	312	3	is	be	AUX
bptjm-46	312	4	an	an	DET
bptjm-46	312	5	amp	amp	PROPN
bptjm-46	312	6	kinase	kinase	NOUN
bptjm-46	312	7	–	–	PUNCT
bptjm-46	312	8	dependent	dependent	ADJ
bptjm-46	312	9	growth	growth	NOUN
bptjm-46	312	10	inhibitor	inhibitor	NOUN
bptjm-46	312	11	for	for	ADP
bptjm-46	312	12	breast	breast	NOUN
bptjm-46	312	13	cancer	cancer	NOUN
bptjm-46	312	14	cells	cell	NOUN
bptjm-46	312	15	.	.	PUNCT
bptjm-46	312	16	”	"	PUNCT
bptjm-46	313	1	cancer	cancer	NOUN
bptjm-46	313	2	research	research	NOUN
bptjm-46	313	3	,	,	PUNCT
bptjm-46	313	4	vol	vol	NOUN
bptjm-46	313	5	.	.	PROPN
bptjm-46	313	6	66	66	NUM
bptjm-46	313	7	,	,	PUNCT
bptjm-46	313	8	no	no	INTJ
bptjm-46	313	9	.	.	NOUN
bptjm-46	313	10	21	21	NUM
bptjm-46	313	11	,	,	PUNCT
bptjm-46	313	12	2006	2006	NUM
bptjm-46	313	13	,	,	PUNCT
bptjm-46	313	14	pp	pp	ADJ
bptjm-46	313	15	.	.	PUNCT
bptjm-46	314	1	10269–10273	10269–10273	NUM
bptjm-46	314	2	.	.	PUNCT
bptjm-46	314	3	,	,	PUNCT
bptjm-46	314	4	doi:10.1158/0008	doi:10.1158/0008	NOUN
bptjm-46	314	5	-	-	PUNCT
bptjm-46	314	6	5472.can-06	5472.can-06	NUM
bptjm-46	314	7	-	-	PUNCT
bptjm-46	314	8	1500	1500	NUM
bptjm-46	314	9	.	.	PUNCT
bptjm-46	315	1	32	32	NUM
bptjm-46	315	2	.	.	PUNCT
bptjm-46	316	1	dhopeshwarkar	dhopeshwarkar	PROPN
bptjm-46	316	2	a	a	PRON
bptjm-46	316	3	,	,	PUNCT
bptjm-46	316	4	mackie	mackie	PROPN
bptjm-46	316	5	k.	k.	PROPN
bptjm-46	316	6	cb2	cb2	PROPN
bptjm-46	316	7	cannabinoid	cannabinoid	PROPN
bptjm-46	316	8	receptors	receptor	NOUN
bptjm-46	316	9	as	as	ADP
bptjm-46	316	10	a	a	DET
bptjm-46	316	11	therapeutic	therapeutic	ADJ
bptjm-46	316	12	target	target	NOUN
bptjm-46	316	13	-	-	PUNCT
bptjm-46	316	14	what	what	PRON
bptjm-46	316	15	does	do	AUX
bptjm-46	316	16	the	the	DET
bptjm-46	316	17	future	future	ADJ
bptjm-46	316	18	hold	hold	VERB
bptjm-46	316	19	?	?	PUNCT
bptjm-46	316	20	.	.	PUNCT
bptjm-46	317	1	mol	mol	ADP
bptjm-46	317	2	pharmacol	pharmacol	PROPN
bptjm-46	317	3	.	.	PUNCT
bptjm-46	318	1	2014;86(4):430	2014;86(4):430	PROPN
bptjm-46	318	2	-	-	PUNCT
bptjm-46	318	3	437	437	NUM
bptjm-46	318	4	.	.	PUNCT
bptjm-46	319	1	doi:10.1124	doi:10.1124	NOUN
bptjm-46	319	2	/	/	PUNCT
bptjm-46	319	3	mol.114.094649	mol.114.094649	PROPN
bptjm-46	319	4	33	33	NUM
bptjm-46	319	5	.	.	PUNCT
bptjm-46	320	1	dowling	dowling	PROPN
bptjm-46	320	2	,	,	PUNCT
bptjm-46	320	3	ryan	ryan	PROPN
bptjm-46	320	4	j.o	j.o	PROPN
bptjm-46	320	5	.	.	PROPN
bptjm-46	320	6	,	,	PUNCT
bptjm-46	320	7	et	et	PROPN
bptjm-46	320	8	al	al	PROPN
bptjm-46	320	9	.	.	PUNCT
bptjm-46	321	1	“	"	PUNCT
bptjm-46	321	2	metformin	metformin	NOUN
bptjm-46	321	3	inhibits	inhibit	VERB
bptjm-46	321	4	mammalian	mammalian	ADJ
bptjm-46	321	5	target	target	NOUN
bptjm-46	321	6	of	of	ADP
bptjm-46	321	7	rapamycin	rapamycin	NOUN
bptjm-46	321	8	–	–	PUNCT
bptjm-46	321	9	dependent	dependent	ADJ
bptjm-46	321	10	translation	translation	NOUN
bptjm-46	321	11	initiation	initiation	NOUN
bptjm-46	321	12	in	in	ADP
bptjm-46	321	13	breast	breast	NOUN
bptjm-46	321	14	cancer	cancer	NOUN
bptjm-46	321	15	cells	cell	NOUN
bptjm-46	321	16	.	.	PUNCT
bptjm-46	321	17	”	"	PUNCT
bptjm-46	322	1	cancer	cancer	NOUN
bptjm-46	322	2	research	research	NOUN
bptjm-46	322	3	,	,	PUNCT
bptjm-46	322	4	vol	vol	NOUN
bptjm-46	322	5	.	.	PROPN
bptjm-46	322	6	67	67	NUM
bptjm-46	322	7	,	,	PUNCT
bptjm-46	322	8	no	no	INTJ
bptjm-46	322	9	.	.	NOUN
bptjm-46	322	10	22	22	NUM
bptjm-46	322	11	,	,	PUNCT
bptjm-46	322	12	2007	2007	NUM
bptjm-46	322	13	,	,	PUNCT
bptjm-46	322	14	pp	pp	ADJ
bptjm-46	322	15	.	.	PUNCT
bptjm-46	323	1	10804–10812	10804–10812	NUM
bptjm-46	323	2	.	.	PUNCT
bptjm-46	323	3	,	,	PUNCT
bptjm-46	323	4	doi:10.1158/0008	doi:10.1158/0008	NOUN
bptjm-46	323	5	-	-	PUNCT
bptjm-46	323	6	5472.can-07	5472.can-07	NOUN
bptjm-46	323	7	-	-	PUNCT
bptjm-46	323	8	2310	2310	NUM
bptjm-46	323	9	.	.	PUNCT
bptjm-46	324	1	34	34	NUM
bptjm-46	324	2	.	.	PUNCT
bptjm-46	324	3	apr	apr	PROPN
bptjm-46	324	4	25	25	NUM
bptjm-46	324	5	,	,	PUNCT
bptjm-46	324	6	2019	2019	NUM
bptjm-46	324	7	.	.	PUNCT
bptjm-46	325	1	(	(	PUNCT
bptjm-46	325	2	n.d	n.d	PROPN
bptjm-46	325	3	.	.	PROPN
bptjm-46	325	4	)	)	PUNCT
bptjm-46	325	5	.	.	PUNCT
bptjm-46	326	1	novel	novel	ADJ
bptjm-46	326	2	mct4	mct4	NOUN
bptjm-46	326	3	inhibitors	inhibitor	NOUN
bptjm-46	326	4	and	and	CCONJ
bptjm-46	326	5	uses	use	VERB
bptjm-46	326	6	thereof	thereof	ADV
bptjm-46	326	7	.	.	PUNCT
bptjm-46	327	1	justia	justia	PROPN
bptjm-46	327	2	.	.	PUNCT
bptjm-46	328	1	retrieved	retrieve	VERB
bptjm-46	328	2	april	april	PROPN
bptjm-46	328	3	8	8	NUM
bptjm-46	328	4	,	,	PUNCT
bptjm-46	328	5	2023	2023	NUM
bptjm-46	328	6	,	,	PUNCT
bptjm-46	328	7	from	from	ADP
bptjm-46	328	8	https://patents.justia.com/patent/20190352282	https://patents.justia.com/patent/20190352282	PROPN
bptjm-46	328	9	35	35	NUM
bptjm-46	328	10	.	.	PUNCT
bptjm-46	329	1	ben	ben	PROPN
bptjm-46	329	2	sahra	sahra	PROPN
bptjm-46	329	3	i.	i.	PROPN
bptjm-46	329	4	,	,	PUNCT
bptjm-46	329	5	laurent	laurent	PROPN
bptjm-46	329	6	k.	k.	PROPN
bptjm-46	329	7	,	,	PUNCT
bptjm-46	329	8	giuliano	giuliano	PROPN
bptjm-46	329	9	s.	s.	PROPN
bptjm-46	329	10	,	,	PUNCT
bptjm-46	329	11	larbret	larbret	PROPN
bptjm-46	329	12	f.	f.	PROPN
bptjm-46	329	13	,	,	PUNCT
bptjm-46	329	14	ponzio	ponzio	PROPN
bptjm-46	329	15	g.	g.	PROPN
bptjm-46	329	16	,	,	PUNCT
bptjm-46	329	17	gounon	gounon	PROPN
bptjm-46	329	18	p.	p.	PROPN
bptjm-46	329	19	,	,	PUNCT
bptjm-46	329	20	le	le	PROPN
bptjm-46	329	21	marchand	marchand	PROPN
bptjm-46	329	22	-	-	PUNCT
bptjm-46	329	23	brustel	brustel	PROPN
bptjm-46	329	24	y.	y.	PROPN
bptjm-46	329	25	,	,	PUNCT
bptjm-46	329	26	giorgetti	giorgetti	NOUN
bptjm-46	329	27	-	-	PUNCT
bptjm-46	329	28	peraldi	peraldi	PROPN
bptjm-46	329	29	s.	s.	PROPN
bptjm-46	329	30	,	,	PUNCT
bptjm-46	329	31	cormont	cormont	NOUN
bptjm-46	329	32	m.	m.	NOUN
bptjm-46	329	33	,	,	PUNCT
bptjm-46	329	34	bertolotto	bertolotto	PROPN
bptjm-46	329	35	c.	c.	PROPN
bptjm-46	329	36	targeting	target	VERB
bptjm-46	329	37	cancer	cancer	NOUN
bptjm-46	329	38	cell	cell	NOUN
bptjm-46	329	39	metabolism	metabolism	NOUN
bptjm-46	329	40	:	:	PUNCT
bptjm-46	329	41	the	the	DET
bptjm-46	329	42	combination	combination	NOUN
bptjm-46	329	43	of	of	ADP
bptjm-46	329	44	metformin	metformin	NOUN
bptjm-46	329	45	and	and	CCONJ
bptjm-46	329	46	2	2	NUM
bptjm-46	329	47	-	-	PUNCT
bptjm-46	329	48	deoxyglucose	deoxyglucose	NOUN
bptjm-46	329	49	induces	induce	VERB
bptjm-46	329	50	p53	p53	NOUN
bptjm-46	329	51	-	-	PUNCT
bptjm-46	329	52	dependent	dependent	ADJ
bptjm-46	329	53	apoptosis	apoptosis	NOUN
bptjm-46	329	54	in	in	ADP
bptjm-46	329	55	prostate	prostate	NOUN
bptjm-46	329	56	cancer	cancer	NOUN
bptjm-46	329	57	cells	cell	NOUN
bptjm-46	329	58	.	.	PUNCT
bptjm-46	330	1	cancer	cancer	NOUN
bptjm-46	330	2	res	re	NOUN
bptjm-46	330	3	.	.	PUNCT
bptjm-46	331	1	2010;70:2465–2475	2010;70:2465–2475	X
bptjm-46	331	2	.	.	PROPN
bptjm-46	331	3	–	–	PUNCT
bptjm-46	331	4	pubmed	pubmed	PROPN
bptjm-46	331	5	36	36	NUM
bptjm-46	331	6	.	.	PUNCT
bptjm-46	332	1	chou	chou	PROPN
bptjm-46	332	2	pc	pc	PROPN
bptjm-46	332	3	,	,	PUNCT
bptjm-46	332	4	choi	choi	NOUN
bptjm-46	332	5	hh	hh	PROPN
bptjm-46	332	6	,	,	PUNCT
bptjm-46	332	7	huang	huang	PROPN
bptjm-46	332	8	y	y	PROPN
bptjm-46	332	9	,	,	PUNCT
bptjm-46	332	10	et	et	PROPN
bptjm-46	332	11	al	al	PROPN
bptjm-46	332	12	.	.	PROPN
bptjm-46	332	13	impact	impact	NOUN
bptjm-46	332	14	of	of	ADP
bptjm-46	332	15	diabetes	diabetes	NOUN
bptjm-46	332	16	on	on	ADP
bptjm-46	332	17	promoting	promote	VERB
bptjm-46	332	18	the	the	DET
bptjm-46	332	19	growth	growth	NOUN
bptjm-46	332	20	of	of	ADP
bptjm-46	332	21	breast	breast	NOUN
bptjm-46	332	22	cancer	cancer	NOUN
bptjm-46	332	23	.	.	PUNCT
bptjm-46	333	1	cancer	cancer	NOUN
bptjm-46	333	2	commun	commun	PROPN
bptjm-46	333	3	(	(	PUNCT
bptjm-46	333	4	lond	lond	PROPN
bptjm-46	333	5	)	)	PUNCT
bptjm-46	333	6	.	.	PUNCT
bptjm-46	334	1	2021;41(5):414	2021;41(5):414	NUM
bptjm-46	334	2	-	-	SYM
bptjm-46	334	3	431	431	NUM
bptjm-46	334	4	.	.	PUNCT
bptjm-46	335	1	doi:10.1002	doi:10.1002	NOUN
bptjm-46	335	2	/	/	SYM
bptjm-46	335	3	cac2.12147	cac2.12147	PROPN
bptjm-46	335	4	37	37	NUM
bptjm-46	335	5	.	.	PUNCT
bptjm-46	336	1	goodwin	goodwin	PROPN
bptjm-46	336	2	pj	pj	PROPN
bptjm-46	336	3	,	,	PUNCT
bptjm-46	336	4	chen	chen	PROPN
bptjm-46	336	5	be	be	AUX
bptjm-46	336	6	,	,	PUNCT
bptjm-46	336	7	gelmon	gelmon	PROPN
bptjm-46	336	8	ka	ka	PROPN
bptjm-46	336	9	,	,	PUNCT
bptjm-46	336	10	et	et	PROPN
bptjm-46	336	11	al	al	PROPN
bptjm-46	336	12	.	.	PUNCT
bptjm-46	337	1	e	e	X
bptjm-46	337	2	�	�	PROPN
bptjm-46	337	3	ect	ect	VERB
bptjm-46	337	4	of	of	ADP
bptjm-46	337	5	metformin	metformin	NOUN
bptjm-46	337	6	vs	vs	ADP
bptjm-46	337	7	placebo	placebo	NOUN
bptjm-46	337	8	on	on	ADP
bptjm-46	337	9	invasive	invasive	ADJ
bptjm-46	337	10	disease	disease	NOUN
bptjm-46	337	11	-	-	PUNCT
bptjm-46	337	12	free	free	ADJ
bptjm-46	337	13	survival	survival	NOUN
bptjm-46	337	14	in	in	ADP
bptjm-46	337	15	patients	patient	NOUN
bptjm-46	337	16	with	with	ADP
bptjm-46	337	17	breast	breast	NOUN
bptjm-46	337	18	cancer	cancer	NOUN
bptjm-46	337	19	:	:	PUNCT
bptjm-46	337	20	thema.32	thema.32	VERB
bptjm-46	337	21	randomized	randomize	VERB
bptjm-46	337	22	clinical	clinical	ADJ
bptjm-46	337	23	trial	trial	NOUN
bptjm-46	337	24	.	.	PUNCT
bptjm-46	338	1	jama	jama	PROPN
bptjm-46	338	2	.	.	PUNCT
bptjm-46	339	1	2022;327(20):1963	2022;327(20):1963	NUM
bptjm-46	339	2	-	-	SYM
bptjm-46	339	3	1973	1973	NUM
bptjm-46	339	4	.	.	PUNCT
bptjm-46	340	1	doi:10.1001	doi:10.1001	NOUN
bptjm-46	340	2	/	/	SYM
bptjm-46	340	3	jama.2022.6147	jama.2022.6147	PROPN
bptjm-46	340	4	38	38	NUM
bptjm-46	340	5	.	.	PUNCT
bptjm-46	341	1	au	au	PROPN
bptjm-46	341	2	yeung	yeung	PROPN
bptjm-46	341	3	sl	sl	PROPN
bptjm-46	341	4	,	,	PUNCT
bptjm-46	341	5	luo	luo	PROPN
bptjm-46	341	6	s	s	PROPN
bptjm-46	341	7	,	,	PUNCT
bptjm-46	341	8	schooling	schooling	NOUN
bptjm-46	341	9	cm	cm	NOUN
bptjm-46	341	10	.	.	PUNCT
bptjm-46	342	1	the	the	DET
bptjm-46	342	2	impact	impact	NOUN
bptjm-46	342	3	of	of	ADP
bptjm-46	342	4	gdf-15	gdf-15	NOUN
bptjm-46	342	5	,	,	PUNCT
bptjm-46	342	6	a	a	DET
bptjm-46	342	7	biomarker	biomarker	NOUN
bptjm-46	342	8	for	for	ADP
bptjm-46	342	9	metformin	metformin	NOUN
bptjm-46	342	10	,	,	PUNCT
bptjm-46	342	11	on	on	ADP
bptjm-46	342	12	the	the	DET
bptjm-46	342	13	risk	risk	NOUN
bptjm-46	342	14	of	of	ADP
bptjm-46	342	15	coronary	coronary	ADJ
bptjm-46	342	16	artery	artery	NOUN
bptjm-46	342	17	disease	disease	NOUN
bptjm-46	342	18	,	,	PUNCT
bptjm-46	342	19	breast	breast	NOUN
bptjm-46	342	20	and	and	CCONJ
bptjm-46	342	21	colorectal	colorectal	ADJ
bptjm-46	342	22	cancer	cancer	NOUN
bptjm-46	342	23	,	,	PUNCT
bptjm-46	342	24	and	and	CCONJ
bptjm-46	342	25	type	type	NOUN
bptjm-46	342	26	2	2	NUM
bptjm-46	342	27	diabetes	diabetes	NOUN
bptjm-46	342	28	and	and	CCONJ
bptjm-46	342	29	metabolic	metabolic	NOUN
bptjm-46	342	30	traits	trait	NOUN
bptjm-46	342	31	:	:	PUNCT
bptjm-46	342	32	a	a	DET
bptjm-46	342	33	mendelian	mendelian	ADJ
bptjm-46	342	34	randomisation	randomisation	NOUN
bptjm-46	342	35	study	study	NOUN
bptjm-46	342	36	.	.	PUNCT
bptjm-46	343	1	diabetologia	diabetologia	NOUN
bptjm-46	343	2	.	.	PUNCT
bptjm-46	344	1	2019;62(9):1638	2019;62(9):1638	NUM
bptjm-46	344	2	-	-	SYM
bptjm-46	344	3	1646	1646	NUM
bptjm-46	344	4	.	.	PUNCT
bptjm-46	345	1	doi:10.1007	doi:10.1007	VERB
bptjm-46	345	2	/	/	SYM
bptjm-46	345	3	s00125	s00125	NOUN
bptjm-46	345	4	-	-	PUNCT
bptjm-46	345	5	019	019	NUM
bptjm-46	345	6	-	-	PUNCT
bptjm-46	345	7	4913	4913	NUM
bptjm-46	345	8	-	-	SYM
bptjm-46	345	9	2	2	NUM
bptjm-46	345	10	39	39	NUM
bptjm-46	345	11	.	.	PUNCT
bptjm-46	346	1	lee	lee	PROPN
bptjm-46	346	2	sh	sh	PROPN
bptjm-46	346	3	,	,	PUNCT
bptjm-46	346	4	hwang	hwang	PROPN
bptjm-46	346	5	hk	hk	PROPN
bptjm-46	346	6	,	,	PUNCT
bptjm-46	346	7	leewj	leewj	PROPN
bptjm-46	346	8	,	,	PUNCT
bptjm-46	346	9	kang	kang	PROPN
bptjm-46	346	10	cm	cm	PROPN
bptjm-46	346	11	.	.	PUNCT
bptjm-46	347	1	mct4	mct4	PROPN
bptjm-46	347	2	as	as	ADP
bptjm-46	347	3	a	a	DET
bptjm-46	347	4	potential	potential	ADJ
bptjm-46	347	5	therapeutic	therapeutic	ADJ
bptjm-46	347	6	target	target	NOUN
bptjm-46	347	7	to	to	PART
bptjm-46	347	8	augment	augment	VERB
bptjm-46	347	9	gemcitabine	gemcitabine	NOUN
bptjm-46	347	10	chemosensitivity	chemosensitivity	NOUN
bptjm-46	347	11	in	in	ADP
bptjm-46	347	12	resected	resect	VERB
bptjm-46	347	13	pancreatic	pancreatic	ADJ
bptjm-46	347	14	cancer	cancer	NOUN
bptjm-46	347	15	.	.	PUNCT
bptjm-46	348	1	cell	cell	NOUN
bptjm-46	348	2	oncol	oncol	ADJ
bptjm-46	348	3	(	(	PUNCT
bptjm-46	348	4	dordr	dordr	ADV
bptjm-46	348	5	)	)	PUNCT
bptjm-46	348	6	.	.	PUNCT
bptjm-46	349	1	2021;44(6):1363	2021;44(6):1363	NUM
bptjm-46	349	2	-	-	SYM
bptjm-46	349	3	1371	1371	NUM
bptjm-46	349	4	.	.	PUNCT
bptjm-46	350	1	doi:10.1007	doi:10.1007	PROPN
bptjm-46	350	2	/	/	SYM
bptjm-46	350	3	s13402	s13402	PROPN
bptjm-46	350	4	-	-	PUNCT
bptjm-46	350	5	021	021	NUM
bptjm-46	350	6	-	-	PUNCT
bptjm-46	350	7	00643	00643	NUM
bptjm-46	350	8	-	-	SYM
bptjm-46	350	9	8chou	8chou	NUM
bptjm-46	350	10	pc	pc	NOUN
bptjm-46	350	11	,	,	PUNCT
bptjm-46	350	12	choi	choi	NOUN
bptjm-46	350	13	hh	hh	PROPN
bptjm-46	350	14	,	,	PUNCT
bptjm-46	350	15	huang	huang	PROPN
bptjm-46	350	16	y	y	PROPN
bptjm-46	350	17	,	,	PUNCT
bptjm-46	350	18	et	et	PROPN
bptjm-46	350	19	al	al	PROPN
bptjm-46	350	20	.	.	PROPN
bptjm-46	350	21	impact	impact	NOUN
bptjm-46	350	22	of	of	ADP
bptjm-46	350	23	diabetes	diabetes	NOUN
bptjm-46	350	24	on	on	ADP
bptjm-46	350	25	promoting	promote	VERB
bptjm-46	350	26	the	the	DET
bptjm-46	350	27	growth	growth	NOUN
bptjm-46	350	28	of	of	ADP
bptjm-46	350	29	breast	breast	NOUN
bptjm-46	350	30	cancer	cancer	NOUN
bptjm-46	350	31	.	.	PUNCT
bptjm-46	351	1	cancer	cancer	NOUN
bptjm-46	351	2	commun	commun	PROPN
bptjm-46	351	3	(	(	PUNCT
bptjm-46	351	4	lond	lond	PROPN
bptjm-46	351	5	)	)	PUNCT
bptjm-46	351	6	.	.	PUNCT
bptjm-46	352	1	2021;41(5):414	2021;41(5):414	NUM
bptjm-46	352	2	-	-	SYM
bptjm-46	352	3	431	431	NUM
bptjm-46	352	4	.	.	PUNCT
bptjm-46	353	1	doi:10.1002	doi:10.1002	NOUN
bptjm-46	353	2	/	/	SYM
bptjm-46	353	3	cac2.12147	cac2.12147	PROPN
bptjm-46	353	4	40.goldberg	40.goldberg	PUNCT
bptjm-46	354	1	fw	fw	ADJ
bptjm-46	354	2	,	,	PUNCT
bptjm-46	354	3	kettle	kettle	NOUN
bptjm-46	354	4	jg	jg	PROPN
bptjm-46	354	5	,	,	PUNCT
bptjm-46	354	6	lamont	lamont	PROPN
bptjm-46	354	7	gm	gm	PROPN
bptjm-46	354	8	,	,	PUNCT
bptjm-46	354	9	et	et	PROPN
bptjm-46	354	10	al	al	PROPN
bptjm-46	354	11	.	.	PROPN
bptjm-46	354	12	discovery	discovery	PROPN
bptjm-46	354	13	of	of	ADP
bptjm-46	354	14	clinical	clinical	ADJ
bptjm-46	354	15	candidate	candidate	NOUN
bptjm-46	354	16	azd0095	azd0095	NOUN
bptjm-46	354	17	,	,	PUNCT
bptjm-46	354	18	a	a	DET
bptjm-46	354	19	selective	selective	ADJ
bptjm-46	354	20	inhibitor	inhibitor	NOUN
bptjm-46	354	21	ofmonocarboxylate	ofmonocarboxylate	NOUN
bptjm-46	354	22	transporter	transporter	NOUN
bptjm-46	354	23	4	4	NUM
bptjm-46	354	24	(	(	PUNCT
bptjm-46	354	25	mct4	mct4	PROPN
bptjm-46	354	26	)	)	PUNCT
bptjm-46	354	27	for	for	ADP
bptjm-46	354	28	oncology	oncology	NOUN
bptjm-46	354	29	.	.	PUNCT
bptjm-46	355	1	j	j	PROPN
bptjm-46	355	2	med	med	PROPN
bptjm-46	355	3	chem	chem	NOUN
bptjm-46	355	4	.	.	PUNCT
bptjm-46	356	1	2023;66(1):384	2023;66(1):384	NUM
bptjm-46	356	2	-	-	SYM
bptjm-46	356	3	397	397	NUM
bptjm-46	356	4	.	.	PUNCT
bptjm-46	357	1	doi:10.1021	doi:10.1021	ADJ
bptjm-46	357	2	/	/	SYM
bptjm-46	357	3	acs.jmedchem.2c01342	acs.jmedchem.2c01342	NOUN
bptjm-46	357	4	41	41	NUM
bptjm-46	357	5	.	.	PUNCT
bptjm-46	358	1	lord	lord	PROPN
bptjm-46	358	2	sr	sr	PROPN
bptjm-46	358	3	,	,	PUNCT
bptjm-46	358	4	chengwc	chengwc	PROPN
bptjm-46	358	5	,	,	PUNCT
bptjm-46	358	6	liu	liu	PROPN
bptjm-46	358	7	d	d	PROPN
bptjm-46	358	8	,	,	PUNCT
bptjm-46	358	9	et	et	PROPN
bptjm-46	358	10	al	al	PROPN
bptjm-46	358	11	.	.	PROPN
bptjm-46	358	12	integrated	integrate	VERB
bptjm-46	358	13	pharmacodynamic	pharmacodynamic	ADJ
bptjm-46	358	14	analysis	analysis	NOUN
bptjm-46	358	15	identi	identi	X
bptjm-46	358	16	�	�	NOUN
bptjm-46	358	17	es	es	X
bptjm-46	358	18	two	two	NUM
bptjm-46	358	19	berkeley	berkeley	PROPN
bptjm-46	358	20	pharma	pharma	PROPN
bptjm-46	358	21	tech	tech	NOUN
bptjm-46	358	22	journal	journal	NOUN
bptjm-46	358	23	of	of	ADP
bptjm-46	358	24	medicine	medicine	NOUN
bptjm-46	358	25	|	|	ADV
bptjm-46	358	26	117	117	NUM
bptjm-46	358	27	metabolic	metabolic	NOUN
bptjm-46	358	28	adaption	adaption	NOUN
bptjm-46	358	29	pathways	pathway	NOUN
bptjm-46	358	30	to	to	AUX
bptjm-46	358	31	metformin	metformin	VERB
bptjm-46	358	32	in	in	ADP
bptjm-46	358	33	breast	breast	NOUN
bptjm-46	358	34	cancer	cancer	NOUN
bptjm-46	358	35	.	.	PUNCT
bptjm-46	359	1	cell	cell	NOUN
bptjm-46	359	2	metab	metab	NOUN
bptjm-46	359	3	.	.	PUNCT
bptjm-46	360	1	2018;28(5):679	2018;28(5):679	NOUN
bptjm-46	360	2	-	-	PUNCT
bptjm-46	360	3	688.e4	688.e4	NUM
bptjm-46	360	4	.	.	PUNCT
bptjm-46	361	1	doi:10.1016	doi:10.1016	PROPN
bptjm-46	361	2	/	/	SYM
bptjm-46	361	3	j.cmet.2018.08.021	j.cmet.2018.08.021	PROPN
bptjm-46	361	4	42	42	NUM
bptjm-46	361	5	.	.	PUNCT
bptjm-46	362	1	birsoy	birsoy	PROPN
bptjm-46	362	2	k.	k.	PROPN
bptjm-46	362	3	,	,	PUNCT
bptjm-46	362	4	wang	wang	PROPN
bptjm-46	362	5	t.	t.	PROPN
bptjm-46	362	6	,	,	PUNCT
bptjm-46	362	7	chenw.w	chenw.w	PROPN
bptjm-46	362	8	.	.	PUNCT
bptjm-46	362	9	,	,	PUNCT
bptjm-46	362	10	freinkman	freinkman	PROPN
bptjm-46	362	11	e.	e.	PROPN
bptjm-46	362	12	,	,	PUNCT
bptjm-46	362	13	abu	abu	PROPN
bptjm-46	362	14	-	-	PUNCT
bptjm-46	362	15	remailehm	remailehm	PROPN
bptjm-46	362	16	.	.	PROPN
bptjm-46	362	17	,	,	PUNCT
bptjm-46	362	18	sabatini	sabatini	PROPN
bptjm-46	362	19	d.m	d.m	PROPN
bptjm-46	362	20	.	.	PUNCT
bptjm-46	363	1	an	an	DET
bptjm-46	363	2	essential	essential	ADJ
bptjm-46	363	3	role	role	NOUN
bptjm-46	363	4	of	of	ADP
bptjm-46	363	5	the	the	DET
bptjm-46	363	6	mitochondrial	mitochondrial	ADJ
bptjm-46	363	7	electron	electron	NOUN
bptjm-46	363	8	transport	transport	NOUN
bptjm-46	363	9	chain	chain	NOUN
bptjm-46	363	10	in	in	ADP
bptjm-46	363	11	cell	cell	NOUN
bptjm-46	363	12	proliferation	proliferation	NOUN
bptjm-46	363	13	is	be	AUX
bptjm-46	363	14	to	to	PART
bptjm-46	363	15	enable	enable	VERB
bptjm-46	363	16	aspartate	aspartate	ADJ
bptjm-46	363	17	synthesis	synthesis	NOUN
bptjm-46	363	18	.	.	PUNCT
bptjm-46	364	1	cell	cell	NOUN
bptjm-46	364	2	.	.	PUNCT
bptjm-46	365	1	2015;162:540–551	2015;162:540–551	X
bptjm-46	365	2	.	.	PUNCT
bptjm-46	366	1	pmc	pmc	PROPN
bptjm-46	366	2	pubmed	pubmed	PROPN
bptjm-46	366	3	43	43	PROPN
bptjm-46	366	4	.	.	PUNCT
bptjm-46	367	1	u.s	u.s	PROPN
bptjm-46	367	2	.	.	PROPN
bptjm-46	367	3	national	national	PROPN
bptjm-46	367	4	library	library	NOUN
bptjm-46	367	5	of	of	ADP
bptjm-46	367	6	medicine	medicine	NOUN
bptjm-46	367	7	.	.	PUNCT
bptjm-46	368	1	(	(	PUNCT
bptjm-46	368	2	n.d	n.d	PROPN
bptjm-46	368	3	.	.	PROPN
bptjm-46	368	4	)	)	PUNCT
bptjm-46	368	5	.	.	PUNCT
bptjm-46	369	1	integrated	integrate	VERB
bptjm-46	369	2	pharmacodynamic	pharmacodynamic	ADJ
bptjm-46	369	3	analysis	analysis	NOUN
bptjm-46	369	4	identifies	identify	VERB
bptjm-46	369	5	two	two	NUM
bptjm-46	369	6	metabolic	metabolic	NOUN
bptjm-46	369	7	adaption	adaption	NOUN
bptjm-46	369	8	pathways	pathway	NOUN
bptjm-46	369	9	to	to	AUX
bptjm-46	369	10	metformin	metformin	VERB
bptjm-46	369	11	in	in	ADP
bptjm-46	369	12	breast	breast	NOUN
bptjm-46	369	13	cancer.cell	cancer.cell	PROPN
bptjm-46	369	14	metabolism	metabolism	NOUN
bptjm-46	369	15	.	.	PUNCT
bptjm-46	370	1	retrieved	retrieve	VERB
bptjm-46	370	2	april	april	PROPN
bptjm-46	370	3	8	8	NUM
bptjm-46	370	4	,	,	PUNCT
bptjm-46	370	5	2023	2023	NUM
bptjm-46	370	6	,	,	PUNCT
bptjm-46	370	7	from	from	ADP
bptjm-46	370	8	https://pubmed.ncbi.nlm.nih.gov/30244975/	https://pubmed.ncbi.nlm.nih.gov/30244975/	PROPN
bptjm-46	370	9	44	44	NUM
bptjm-46	370	10	.	.	PUNCT
bptjm-46	370	11	44	44	NUM
bptjm-46	370	12	.	.	PUNCT
bptjm-46	371	1	anders	anders	PROPN
bptjm-46	371	2	s.	s.	PROPN
bptjm-46	371	3	,	,	PUNCT
bptjm-46	371	4	huber	huber	PROPN
bptjm-46	371	5	w.	w.	PROPN
bptjm-46	371	6	di	di	PROPN
bptjm-46	371	7	�	�	PROPN
bptjm-46	371	8	erential	erential	ADJ
bptjm-46	371	9	expression	expression	NOUN
bptjm-46	371	10	analysis	analysis	NOUN
bptjm-46	371	11	for	for	ADP
bptjm-46	371	12	sequence	sequence	NOUN
bptjm-46	371	13	count	count	NOUN
bptjm-46	371	14	data	datum	NOUN
bptjm-46	371	15	.	.	PUNCT
bptjm-46	372	1	genome	genome	NOUN
bptjm-46	372	2	biol	biol	NOUN
bptjm-46	372	3	.	.	PUNCT
bptjm-46	373	1	2010;11	2010;11	NUM
bptjm-46	373	2	:	:	PUNCT
bptjm-46	374	1	r106	r106	NUM
bptjm-46	374	2	.	.	PUNCT
bptjm-46	375	1	pmc	pmc	PROPN
bptjm-46	375	2	pubmed	pubmed	PROPN
bptjm-46	375	3	45	45	PROPN
bptjm-46	375	4	.	.	PUNCT
bptjm-46	375	5	memmott	memmott	PROPN
bptjm-46	375	6	,	,	PUNCT
bptjm-46	375	7	reganm	reganm	PROPN
bptjm-46	375	8	.	.	PROPN
bptjm-46	375	9	,	,	PUNCT
bptjm-46	375	10	et	et	PROPN
bptjm-46	375	11	al	al	PROPN
bptjm-46	375	12	.	.	PUNCT
bptjm-46	376	1	“	"	PUNCT
bptjm-46	376	2	metformin	metformin	NOUN
bptjm-46	376	3	prevents	prevent	VERB
bptjm-46	376	4	tobacco	tobacco	NOUN
bptjm-46	376	5	carcinogen	carcinogen	NOUN
bptjm-46	376	6	–	–	PUNCT
bptjm-46	376	7	induced	induced	ADJ
bptjm-46	376	8	lung	lung	NOUN
bptjm-46	376	9	tumorigenesis	tumorigenesis	NOUN
bptjm-46	376	10	.	.	PUNCT
bptjm-46	376	11	”	"	PUNCT
bptjm-46	377	1	cancer	cancer	NOUN
bptjm-46	377	2	prevention	prevention	NOUN
bptjm-46	377	3	research	research	NOUN
bptjm-46	377	4	,	,	PUNCT
bptjm-46	377	5	vol	vol	NOUN
bptjm-46	377	6	.	.	PROPN
bptjm-46	378	1	3	3	NUM
bptjm-46	378	2	,	,	PUNCT
bptjm-46	378	3	no	no	INTJ
bptjm-46	378	4	.	.	NOUN
bptjm-46	378	5	9	9	NUM
bptjm-46	378	6	,	,	PUNCT
bptjm-46	378	7	2010	2010	NUM
bptjm-46	378	8	,	,	PUNCT
bptjm-46	378	9	pp	pp	ADJ
bptjm-46	378	10	.	.	PUNCT
bptjm-46	379	1	1066–1076	1066–1076	NUM
bptjm-46	379	2	.	.	PUNCT
bptjm-46	379	3	,	,	PUNCT
bptjm-46	379	4	doi:10.1158/1940	doi:10.1158/1940	NOUN
bptjm-46	379	5	-	-	PUNCT
bptjm-46	379	6	6207.capr-10	6207.capr-10	NUM
bptjm-46	379	7	-	-	PUNCT
bptjm-46	379	8	0055	0055	NUM
bptjm-46	379	9	.	.	PUNCT
bptjm-46	380	1	46	46	NUM
bptjm-46	380	2	.	.	PUNCT
bptjm-46	381	1	wilson	wilson	PROPN
bptjm-46	381	2	pm	pm	PROPN
bptjm-46	381	3	,	,	PUNCT
bptjm-46	381	4	yang	yang	PROPN
bptjm-46	381	5	d	d	PROPN
bptjm-46	381	6	,	,	PUNCT
bptjm-46	381	7	azumam	azumam	NOUN
bptjm-46	381	8	,	,	PUNCT
bptjm-46	381	9	et	et	PROPN
bptjm-46	381	10	al	al	PROPN
bptjm-46	381	11	.	.	PROPN
bptjm-46	382	1	intratumoral	intratumoral	ADJ
bptjm-46	382	2	expression	expression	NOUN
bptjm-46	382	3	pro	pro	X
bptjm-46	382	4	�	�	VERB
bptjm-46	382	5	ling	ling	NOUN
bptjm-46	382	6	of	of	ADP
bptjm-46	382	7	genes	gene	NOUN
bptjm-46	382	8	involved	involve	VERB
bptjm-46	382	9	in	in	ADP
bptjm-46	382	10	angiogenesis	angiogenesis	NOUN
bptjm-46	382	11	in	in	ADP
bptjm-46	382	12	colorectal	colorectal	ADJ
bptjm-46	382	13	cancer	cancer	NOUN
bptjm-46	382	14	patients	patient	NOUN
bptjm-46	382	15	treated	treat	VERB
bptjm-46	382	16	with	with	ADP
bptjm-46	382	17	chemotherapy	chemotherapy	NOUN
bptjm-46	382	18	plus	plus	CCONJ
bptjm-46	382	19	the	the	DET
bptjm-46	382	20	vegfr	vegfr	ADJ
bptjm-46	382	21	inhibitor	inhibitor	NOUN
bptjm-46	382	22	ptk787	ptk787	PROPN
bptjm-46	382	23	/	/	SYM
bptjm-46	382	24	zk	zk	PROPN
bptjm-46	382	25	222584	222584	NUM
bptjm-46	382	26	(	(	PUNCT
bptjm-46	382	27	vatalanib	vatalanib	PROPN
bptjm-46	382	28	)	)	PUNCT
bptjm-46	382	29	.	.	PUNCT
bptjm-46	383	1	pharmacogenomics	pharmacogenomics	PROPN
bptjm-46	383	2	j.	j.	PROPN
bptjm-46	383	3	2013;13(5):410	2013;13(5):410	PROPN
bptjm-46	383	4	-	-	PUNCT
bptjm-46	383	5	416	416	NUM
bptjm-46	383	6	.	.	PUNCT
bptjm-46	383	7	doi:10.1038	doi:10.1038	NOUN
bptjm-46	383	8	/	/	SYM
bptjm-46	383	9	tpj.2012.23	tpj.2012.23	PROPN
bptjm-46	383	10	47	47	NUM
bptjm-46	383	11	.	.	PUNCT
bptjm-46	384	1	dowling	dowle	VERB
bptjm-46	384	2	rj	rj	PROPN
bptjm-46	384	3	,	,	PUNCT
bptjm-46	384	4	zakikhani	zakikhani	X
bptjm-46	384	5	m	m	PROPN
bptjm-46	384	6	,	,	PUNCT
bptjm-46	384	7	fantus	fantus	PROPN
bptjm-46	384	8	ig	ig	PROPN
bptjm-46	384	9	,	,	PUNCT
bptjm-46	384	10	pollak	pollak	PROPN
bptjm-46	384	11	m	m	PROPN
bptjm-46	384	12	,	,	PUNCT
bptjm-46	384	13	sonenberg	sonenberg	PROPN
bptjm-46	384	14	n.	n.	PROPN
bptjm-46	384	15	metformin	metformin	PROPN
bptjm-46	384	16	inhibits	inhibit	VERB
bptjm-46	384	17	mammalian	mammalian	ADJ
bptjm-46	384	18	target	target	NOUN
bptjm-46	384	19	of	of	ADP
bptjm-46	384	20	rapamycin	rapamycin	NOUN
bptjm-46	384	21	-	-	PUNCT
bptjm-46	384	22	dependent	dependent	ADJ
bptjm-46	384	23	translation	translation	NOUN
bptjm-46	384	24	initiation	initiation	NOUN
bptjm-46	384	25	in	in	ADP
bptjm-46	384	26	breast	breast	NOUN
bptjm-46	384	27	cancer	cancer	NOUN
bptjm-46	384	28	cells	cell	NOUN
bptjm-46	384	29	.	.	PUNCT
bptjm-46	385	1	cancer	cancer	NOUN
bptjm-46	385	2	res	re	NOUN
bptjm-46	385	3	.	.	PUNCT
bptjm-46	386	1	2007;67(22):10804	2007;67(22):10804	NUM
bptjm-46	386	2	-	-	SYM
bptjm-46	386	3	10812	10812	NUM
bptjm-46	386	4	.	.	PUNCT
bptjm-46	387	1	doi:10.1158/0008	doi:10.1158/0008	NOUN
bptjm-46	387	2	-	-	PUNCT
bptjm-46	387	3	5472.can-07	5472.can-07	NOUN
bptjm-46	387	4	-	-	PUNCT
bptjm-46	387	5	2310	2310	NUM
bptjm-46	387	6	48	48	NUM
bptjm-46	387	7	.	.	PUNCT
bptjm-46	388	1	vernieri	vernieri	PROPN
bptjm-46	388	2	c	c	PROPN
bptjm-46	388	3	,	,	PUNCT
bptjm-46	388	4	signorelli	signorelli	PROPN
bptjm-46	388	5	d	d	NOUN
bptjm-46	388	6	,	,	PUNCT
bptjm-46	388	7	galli	galli	NOUN
bptjm-46	388	8	g	g	NOUN
bptjm-46	388	9	,	,	PUNCT
bptjm-46	388	10	et	et	PROPN
bptjm-46	388	11	al	al	PROPN
bptjm-46	388	12	.	.	PUNCT
bptjm-46	388	13	exploiting	exploit	VERB
bptjm-46	388	14	fasting	fast	VERB
bptjm-46	388	15	-	-	PUNCT
bptjm-46	388	16	mimicking	mimic	VERB
bptjm-46	388	17	diet	diet	NOUN
bptjm-46	388	18	and	and	CCONJ
bptjm-46	388	19	metformin	metformin	NOUN
bptjm-46	388	20	to	to	PART
bptjm-46	388	21	improve	improve	VERB
bptjm-46	388	22	the	the	DET
bptjm-46	388	23	e	e	PROPN
bptjm-46	388	24	�	�	NOUN
bptjm-46	388	25	cacy	cacy	NOUN
bptjm-46	388	26	of	of	ADP
bptjm-46	388	27	platinum	platinum	NOUN
bptjm-46	388	28	-	-	PUNCT
bptjm-46	388	29	pemetrexed	pemetrexe	VERB
bptjm-46	388	30	chemotherapy	chemotherapy	NOUN
bptjm-46	388	31	in	in	ADP
bptjm-46	388	32	advanced	advanced	ADJ
bptjm-46	388	33	lkb1	lkb1	NOUN
bptjm-46	388	34	-	-	PUNCT
bptjm-46	388	35	inactivated	inactivate	VERB
bptjm-46	388	36	lung	lung	NOUN
bptjm-46	388	37	adenocarcinoma	adenocarcinoma	NOUN
bptjm-46	388	38	:	:	PUNCT
bptjm-46	388	39	the	the	DET
bptjm-46	388	40	fame	fame	NOUN
bptjm-46	388	41	trial	trial	NOUN
bptjm-46	388	42	.	.	PUNCT
bptjm-46	389	1	clin	clin	PROPN
bptjm-46	389	2	lung	lung	NOUN
bptjm-46	389	3	cancer	cancer	NOUN
bptjm-46	389	4	.	.	PUNCT
bptjm-46	390	1	2019;20(3):e413	2019;20(3):e413	PROPN
bptjm-46	390	2	-	-	PUNCT
bptjm-46	390	3	e417	e417	PROPN
bptjm-46	390	4	.	.	PUNCT
bptjm-46	390	5	doi:10.1016	doi:10.1016	PROPN
bptjm-46	390	6	/	/	SYM
bptjm-46	390	7	j.cllc.2018.12.011	j.cllc.2018.12.011	PROPN
bptjm-46	390	8	49	49	NUM
bptjm-46	390	9	.	.	PUNCT
bptjm-46	391	1	marinello	marinello	PROPN
bptjm-46	391	2	pc	pc	PROPN
bptjm-46	391	3	,	,	PUNCT
bptjm-46	391	4	da	da	PROPN
bptjm-46	391	5	silva	silva	PROPN
bptjm-46	391	6	tn	tn	PROPN
bptjm-46	391	7	,	,	PUNCT
bptjm-46	391	8	panis	panis	PROPN
bptjm-46	391	9	c	c	AUX
bptjm-46	391	10	,	,	PUNCT
bptjm-46	391	11	et	et	PROPN
bptjm-46	391	12	al	al	PROPN
bptjm-46	391	13	.	.	PUNCT
bptjm-46	391	14	mechanism	mechanism	NOUN
bptjm-46	391	15	of	of	ADP
bptjm-46	391	16	metformin	metformin	NOUN
bptjm-46	391	17	action	action	NOUN
bptjm-46	391	18	inmcf-7	inmcf-7	CCONJ
bptjm-46	391	19	and	and	CCONJ
bptjm-46	391	20	mda	mda	PROPN
bptjm-46	391	21	-	-	PUNCT
bptjm-46	391	22	mb-231	mb-231	PROPN
bptjm-46	391	23	human	human	ADJ
bptjm-46	391	24	breast	breast	NOUN
bptjm-46	391	25	cancer	cancer	NOUN
bptjm-46	391	26	cells	cell	NOUN
bptjm-46	391	27	involves	involve	VERB
bptjm-46	391	28	oxidative	oxidative	ADJ
bptjm-46	391	29	stress	stress	NOUN
bptjm-46	391	30	generation	generation	NOUN
bptjm-46	391	31	,	,	PUNCT
bptjm-46	391	32	dna	dna	NOUN
bptjm-46	391	33	damage	damage	NOUN
bptjm-46	391	34	,	,	PUNCT
bptjm-46	391	35	and	and	CCONJ
bptjm-46	391	36	transforming	transform	VERB
bptjm-46	391	37	growth	growth	NOUN
bptjm-46	391	38	factor	factor	NOUN
bptjm-46	391	39	β1	β1	NOUN
bptjm-46	391	40	induction	induction	NOUN
bptjm-46	391	41	.	.	PUNCT
bptjm-46	392	1	tumour	tumour	PROPN
bptjm-46	392	2	biol	biol	PROPN
bptjm-46	392	3	.	.	PUNCT
bptjm-46	393	1	2016;37(4):5337	2016;37(4):5337	NUM
bptjm-46	393	2	-	-	SYM
bptjm-46	393	3	5346	5346	NUM
bptjm-46	393	4	.	.	PUNCT
bptjm-46	394	1	doi:10.1007	doi:10.1007	VERB
bptjm-46	394	2	/	/	SYM
bptjm-46	394	3	s13277	s13277	NOUN
bptjm-46	394	4	-	-	PUNCT
bptjm-46	394	5	015	015	NUM
bptjm-46	394	6	-	-	PUNCT
bptjm-46	394	7	4395	4395	NUM
bptjm-46	394	8	-	-	PUNCT
bptjm-46	394	9	x	x	SYM
bptjm-46	394	10	50	50	NUM
bptjm-46	394	11	.	.	PUNCT
bptjm-46	395	1	gilad	gilad	PROPN
bptjm-46	395	2	y	y	PROPN
bptjm-46	395	3	,	,	PUNCT
bptjm-46	395	4	gellerman	gellerman	NOUN
bptjm-46	395	5	g	g	NOUN
bptjm-46	395	6	,	,	PUNCT
bptjm-46	395	7	lonard	lonard	NOUN
bptjm-46	395	8	dm	dm	PROPN
bptjm-46	395	9	,	,	PUNCT
bptjm-46	395	10	o'malley	o'malley	PROPN
bptjm-46	395	11	bw	bw	PROPN
bptjm-46	395	12	.	.	PROPN
bptjm-46	395	13	drug	drug	NOUN
bptjm-46	395	14	combination	combination	NOUN
bptjm-46	395	15	in	in	ADP
bptjm-46	395	16	cancer	cancer	NOUN
bptjm-46	395	17	treatment	treatment	NOUN
bptjm-46	395	18	-	-	PUNCT
bptjm-46	395	19	from	from	ADP
bptjm-46	395	20	cocktails	cocktail	NOUN
bptjm-46	395	21	to	to	ADP
bptjm-46	395	22	conjugated	conjugate	VERB
bptjm-46	395	23	combinations	combination	NOUN
bptjm-46	395	24	.	.	PUNCT
bptjm-46	396	1	cancers	cancer	NOUN
bptjm-46	396	2	(	(	PUNCT
bptjm-46	396	3	basel	basel	PROPN
bptjm-46	396	4	)	)	PUNCT
bptjm-46	396	5	.	.	PUNCT
bptjm-46	397	1	2021;13(4):669	2021;13(4):669	NUM
bptjm-46	397	2	.	.	PUNCT
bptjm-46	398	1	published	publish	VERB
bptjm-46	398	2	2021	2021	NUM
bptjm-46	398	3	feb	feb	NOUN
bptjm-46	398	4	7	7	NUM
bptjm-46	398	5	.	.	PUNCT
bptjm-46	398	6	doi:10.3390	doi:10.3390	NOUN
bptjm-46	398	7	/	/	SYM
bptjm-46	398	8	cancers13040669	cancers13040669	PROPN
bptjm-46	398	9	berkeley	berkeley	PROPN
bptjm-46	398	10	pharma	pharma	PROPN
bptjm-46	398	11	tech	tech	NOUN
bptjm-46	398	12	journal	journal	NOUN
bptjm-46	398	13	of	of	ADP
bptjm-46	398	14	medicine	medicine	NOUN
bptjm-46	398	15	|	|	ADV
bptjm-46	398	16	118	118	NUM