id	sid	tid	token	lemma	pos
bptjm-57	1	1	berkeley	berkeley	PROPN
bptjm-57	1	2	pharma	pharma	PROPN
bptjm-57	1	3	tech	tech	NOUN
bptjm-57	1	4	journal	journal	NOUN
bptjm-57	1	5	of	of	ADP
bptjm-57	1	6	medicine	medicine	NOUN
bptjm-57	1	7	correspondence	correspondence	NOUN
bptjm-57	1	8	:	:	PUNCT
bptjm-57	1	9	gonzaga.patriciaangelica@gmail.com	gonzaga.patriciaangelica@gmail.com	X
bptjm-57	1	10	keywords	keyword	NOUN
bptjm-57	1	11	:	:	PUNCT
bptjm-57	1	12	tumor	tumor	NOUN
bptjm-57	1	13	heterogeneity	heterogeneity	NOUN
bptjm-57	1	14	,	,	PUNCT
bptjm-57	1	15	immunotherapy	immunotherapy	NOUN
bptjm-57	1	16	,	,	PUNCT
bptjm-57	1	17	cancer	cancer	NOUN
bptjm-57	1	18	,	,	PUNCT
bptjm-57	1	19	dual/	dual/	NUM
bptjm-57	1	20	multi	multi	NOUN
bptjm-57	1	21	ex	ex	X
bptjm-57	1	22	vivo	vivo	ADJ
bptjm-57	1	23	armed	armed	ADJ
bptjm-57	1	24	t	t	PROPN
bptjm-57	1	25	cells	cell	NOUN
bptjm-57	1	26	(	(	PUNCT
bptjm-57	1	27	eats	eat	NOUN
bptjm-57	1	28	)	)	PUNCT
bptjm-57	1	29	,	,	PUNCT
bptjm-57	1	30	nanornps	nanornps	PROPN
bptjm-57	1	31	,	,	PUNCT
bptjm-57	1	32	car	car	NOUN
bptjm-57	1	33	-	-	PUNCT
bptjm-57	1	34	t	t	NOUN
bptjm-57	1	35	cell	cell	NOUN
bptjm-57	1	36	therapy	therapy	NOUN
bptjm-57	1	37	submitted	submit	VERB
bptjm-57	1	38	august	august	PROPN
bptjm-57	1	39	11	11	NUM
bptjm-57	1	40	,	,	PUNCT
bptjm-57	1	41	2023	2023	NUM
bptjm-57	1	42	accepted	accept	VERB
bptjm-57	1	43	april	april	PROPN
bptjm-57	1	44	5	5	NUM
bptjm-57	1	45	,	,	PUNCT
bptjm-57	1	46	2024	2024	NUM
bptjm-57	1	47	published	publish	VERB
bptjm-57	1	48	june	june	PROPN
bptjm-57	1	49	28	28	NUM
bptjm-57	1	50	,	,	PUNCT
bptjm-57	1	51	2024	2024	NUM
bptjm-57	1	52	full	full	ADJ
bptjm-57	1	53	open	open	ADJ
bptjm-57	1	54	access	access	NOUN
bptjm-57	1	55	creative	creative	ADJ
bptjm-57	1	56	commons	common	NOUN
bptjm-57	1	57	attribution	attribution	NOUN
bptjm-57	1	58	license	license	VERB
bptjm-57	1	59	4.0	4.0	NUM
bptjm-57	1	60	abstract	abstract	ADJ
bptjm-57	1	61	tumor	tumor	NOUN
bptjm-57	1	62	heterogeneity	heterogeneity	NOUN
bptjm-57	1	63	refers	refer	VERB
bptjm-57	1	64	to	to	ADP
bptjm-57	1	65	the	the	DET
bptjm-57	1	66	phenomenon	phenomenon	NOUN
bptjm-57	1	67	when	when	SCONJ
bptjm-57	1	68	tumors	tumor	NOUN
bptjm-57	1	69	possess	possess	VERB
bptjm-57	1	70	a	a	DET
bptjm-57	1	71	medley	medley	NOUN
bptjm-57	1	72	of	of	ADP
bptjm-57	1	73	cell	cell	NOUN
bptjm-57	1	74	types	type	NOUN
bptjm-57	1	75	,	,	PUNCT
bptjm-57	1	76	and	and	CCONJ
bptjm-57	1	77	it	it	PRON
bptjm-57	1	78	is	be	AUX
bptjm-57	1	79	one	one	NUM
bptjm-57	1	80	of	of	ADP
bptjm-57	1	81	the	the	DET
bptjm-57	1	82	central	central	ADJ
bptjm-57	1	83	challenges	challenge	NOUN
bptjm-57	1	84	facing	face	VERB
bptjm-57	1	85	cancer	cancer	NOUN
bptjm-57	1	86	treatment	treatment	NOUN
bptjm-57	1	87	as	as	SCONJ
bptjm-57	1	88	it	it	PRON
bptjm-57	1	89	is	be	AUX
bptjm-57	1	90	associated	associate	VERB
bptjm-57	1	91	with	with	ADP
bptjm-57	1	92	drug	drug	NOUN
bptjm-57	1	93	resistance	resistance	NOUN
bptjm-57	1	94	and	and	CCONJ
bptjm-57	1	95	worse	bad	ADJ
bptjm-57	1	96	prognosis	prognosis	NOUN
bptjm-57	1	97	.	.	PUNCT
bptjm-57	2	1	each	each	DET
bptjm-57	2	2	cell	cell	NOUN
bptjm-57	2	3	type	type	NOUN
bptjm-57	2	4	responds	respond	VERB
bptjm-57	2	5	to	to	ADP
bptjm-57	2	6	treatment	treatment	NOUN
bptjm-57	2	7	in	in	ADP
bptjm-57	2	8	a	a	DET
bptjm-57	2	9	unique	unique	ADJ
bptjm-57	2	10	way	way	NOUN
bptjm-57	2	11	,	,	PUNCT
bptjm-57	2	12	thus	thus	ADV
bptjm-57	2	13	tumors	tumor	NOUN
bptjm-57	2	14	with	with	ADP
bptjm-57	2	15	high	high	ADJ
bptjm-57	2	16	levels	level	NOUN
bptjm-57	2	17	of	of	ADP
bptjm-57	2	18	heterogeneity	heterogeneity	NOUN
bptjm-57	2	19	are	be	AUX
bptjm-57	2	20	not	not	PART
bptjm-57	2	21	often	often	ADV
bptjm-57	2	22	fully	fully	ADV
bptjm-57	2	23	treated	treat	VERB
bptjm-57	2	24	by	by	ADP
bptjm-57	2	25	typical	typical	ADJ
bptjm-57	2	26	cancer	cancer	NOUN
bptjm-57	2	27	therapies	therapy	NOUN
bptjm-57	2	28	.	.	PUNCT
bptjm-57	3	1	there	there	PRON
bptjm-57	3	2	are	be	VERB
bptjm-57	3	3	a	a	DET
bptjm-57	3	4	variety	variety	NOUN
bptjm-57	3	5	of	of	ADP
bptjm-57	3	6	novel	novel	ADJ
bptjm-57	3	7	treatments	treatment	NOUN
bptjm-57	3	8	being	be	AUX
bptjm-57	3	9	developed	develop	VERB
bptjm-57	3	10	that	that	PRON
bptjm-57	3	11	aim	aim	NOUN
bptjm-57	3	12	to	to	PART
bptjm-57	3	13	eliminate	eliminate	VERB
bptjm-57	3	14	the	the	DET
bptjm-57	3	15	obstacle	obstacle	NOUN
bptjm-57	3	16	that	that	PRON
bptjm-57	3	17	heterogeneity	heterogeneity	NOUN
bptjm-57	3	18	poses	pose	VERB
bptjm-57	3	19	by	by	ADP
bptjm-57	3	20	utilizing	utilize	VERB
bptjm-57	3	21	more	more	ADJ
bptjm-57	3	22	personalized	personalized	ADJ
bptjm-57	3	23	approaches	approach	NOUN
bptjm-57	3	24	.	.	PUNCT
bptjm-57	4	1	this	this	DET
bptjm-57	4	2	review	review	NOUN
bptjm-57	4	3	assesses	assess	VERB
bptjm-57	4	4	immunotherapy	immunotherapy	NOUN
bptjm-57	4	5	,	,	PUNCT
bptjm-57	4	6	combination	combination	NOUN
bptjm-57	4	7	therapy	therapy	NOUN
bptjm-57	4	8	,	,	PUNCT
bptjm-57	4	9	dualor	dualor	NOUN
bptjm-57	4	10	multi	multi	ADJ
bptjm-57	4	11	-	-	ADJ
bptjm-57	4	12	ex	ex	ADJ
bptjm-57	4	13	vivo	vivo	ADJ
bptjm-57	4	14	armed	armed	ADJ
bptjm-57	4	15	t	t	NOUN
bptjm-57	4	16	cells	cell	NOUN
bptjm-57	4	17	,	,	PUNCT
bptjm-57	4	18	and	and	CCONJ
bptjm-57	4	19	a	a	DET
bptjm-57	4	20	nano	nano	NOUN
bptjm-57	4	21	-	-	PUNCT
bptjm-57	4	22	cas9	cas9	NOUN
bptjm-57	4	23	ribonucleoprotein	ribonucleoprotein	NOUN
bptjm-57	4	24	system	system	NOUN
bptjm-57	4	25	as	as	ADP
bptjm-57	4	26	treatment	treatment	NOUN
bptjm-57	4	27	strategies	strategy	NOUN
bptjm-57	4	28	.	.	PUNCT
bptjm-57	5	1	although	although	SCONJ
bptjm-57	5	2	further	further	ADJ
bptjm-57	5	3	research	research	NOUN
bptjm-57	5	4	is	be	AUX
bptjm-57	5	5	required	require	VERB
bptjm-57	5	6	to	to	PART
bptjm-57	5	7	ensure	ensure	VERB
bptjm-57	5	8	their	their	PRON
bptjm-57	5	9	clinical	clinical	ADJ
bptjm-57	5	10	safety	safety	NOUN
bptjm-57	5	11	,	,	PUNCT
bptjm-57	5	12	these	these	DET
bptjm-57	5	13	treatments	treatment	NOUN
bptjm-57	5	14	show	show	VERB
bptjm-57	5	15	their	their	PRON
bptjm-57	5	16	potential	potential	NOUN
bptjm-57	5	17	to	to	PART
bptjm-57	5	18	overcome	overcome	VERB
bptjm-57	5	19	the	the	DET
bptjm-57	5	20	challenges	challenge	NOUN
bptjm-57	5	21	posed	pose	VERB
bptjm-57	5	22	by	by	ADP
bptjm-57	5	23	tumor	tumor	NOUN
bptjm-57	5	24	heterogeneity	heterogeneity	NOUN
bptjm-57	5	25	in	in	ADP
bptjm-57	5	26	cancer	cancer	NOUN
bptjm-57	5	27	development	development	NOUN
bptjm-57	5	28	.	.	PUNCT
bptjm-57	6	1	this	this	DET
bptjm-57	6	2	paper	paper	NOUN
bptjm-57	6	3	also	also	ADV
bptjm-57	6	4	discusses	discuss	VERB
bptjm-57	6	5	circulating	circulate	VERB
bptjm-57	6	6	tumor	tumor	NOUN
bptjm-57	6	7	cells	cell	NOUN
bptjm-57	6	8	as	as	ADP
bptjm-57	6	9	a	a	DET
bptjm-57	6	10	way	way	NOUN
bptjm-57	6	11	to	to	PART
bptjm-57	6	12	test	test	VERB
bptjm-57	6	13	therapeutic	therapeutic	ADJ
bptjm-57	6	14	drugs	drug	NOUN
bptjm-57	6	15	and	and	CCONJ
bptjm-57	6	16	determine	determine	VERB
bptjm-57	6	17	treatment	treatment	NOUN
bptjm-57	6	18	progress	progress	NOUN
bptjm-57	6	19	.	.	PUNCT
bptjm-57	7	1	tumor	tumor	NOUN
bptjm-57	7	2	heterogeneity	heterogeneity	NOUN
bptjm-57	7	3	and	and	CCONJ
bptjm-57	7	4	therapeutic	therapeutic	ADJ
bptjm-57	7	5	challenges	challenge	NOUN
bptjm-57	7	6	:	:	PUNCT
bptjm-57	7	7	exploring	explore	VERB
bptjm-57	7	8	approaches	approach	NOUN
bptjm-57	7	9	and	and	CCONJ
bptjm-57	7	10	future	future	ADJ
bptjm-57	7	11	directions	direction	NOUN
bptjm-57	7	12	by	by	ADP
bptjm-57	7	13	:	:	PUNCT
bptjm-57	7	14	patricia	patricia	PROPN
bptjm-57	7	15	gonzaga	gonzaga	PROPN
bptjm-57	7	16	,	,	PUNCT
bptjm-57	7	17	ammabel	ammabel	NOUN
bptjm-57	7	18	tukiman	tukiman	NOUN
bptjm-57	7	19	,	,	PUNCT
bptjm-57	7	20	noelie	noelie	ADJ
bptjm-57	7	21	macmullan	macmullan	PROPN
bptjm-57	7	22	,	,	PUNCT
bptjm-57	7	23	jason	jason	PROPN
bptjm-57	7	24	park	park	PROPN
bptjm-57	7	25	,	,	PUNCT
bptjm-57	7	26	m.s	m.s	PROPN
bptjm-57	7	27	.	.	PROPN
bptjm-57	7	28	1	1	NUM
bptjm-57	7	29	.	.	PUNCT
bptjm-57	7	30	introduction	introduction	NOUN
bptjm-57	7	31	cancer	cancer	NOUN
bptjm-57	7	32	,	,	PUNCT
bptjm-57	7	33	a	a	DET
bptjm-57	7	34	disease	disease	NOUN
bptjm-57	7	35	in	in	ADP
bptjm-57	7	36	which	which	PRON
bptjm-57	7	37	cells	cell	NOUN
bptjm-57	7	38	grow	grow	VERB
bptjm-57	7	39	uncontrollably	uncontrollably	ADV
bptjm-57	7	40	,	,	PUNCT
bptjm-57	7	41	was	be	AUX
bptjm-57	7	42	one	one	NUM
bptjm-57	7	43	of	of	ADP
bptjm-57	7	44	the	the	DET
bptjm-57	7	45	three	three	NUM
bptjm-57	7	46	leading	lead	VERB
bptjm-57	7	47	causes	cause	NOUN
bptjm-57	7	48	of	of	ADP
bptjm-57	7	49	death	death	NOUN
bptjm-57	7	50	in	in	ADP
bptjm-57	7	51	2022	2022	NUM
bptjm-57	7	52	,	,	PUNCT
bptjm-57	7	53	with	with	ADP
bptjm-57	7	54	607,790	607,790	NUM
bptjm-57	7	55	deaths	death	NOUN
bptjm-57	7	56	in	in	ADP
bptjm-57	7	57	the	the	DET
bptjm-57	7	58	u.s.1	u.s.1	NOUN
bptjm-57	7	59	in	in	ADP
bptjm-57	7	60	2023	2023	NUM
bptjm-57	7	61	,	,	PUNCT
bptjm-57	7	62	an	an	DET
bptjm-57	7	63	estimated	estimate	VERB
bptjm-57	7	64	609,820	609,820	NUM
bptjm-57	7	65	out	out	ADP
bptjm-57	7	66	of	of	ADP
bptjm-57	7	67	roughly	roughly	ADV
bptjm-57	7	68	2	2	NUM
bptjm-57	7	69	million	million	NUM
bptjm-57	7	70	people	people	NOUN
bptjm-57	7	71	in	in	ADP
bptjm-57	7	72	the	the	DET
bptjm-57	7	73	u.s	u.s	PROPN
bptjm-57	7	74	.	.	PROPN
bptjm-57	7	75	were	be	AUX
bptjm-57	7	76	predicted	predict	VERB
bptjm-57	7	77	to	to	PART
bptjm-57	7	78	die	die	VERB
bptjm-57	7	79	of	of	ADP
bptjm-57	7	80	cancer.2	cancer.2	PROPN
bptjm-57	7	81	however	however	ADV
bptjm-57	7	82	,	,	PUNCT
bptjm-57	7	83	treating	treat	VERB
bptjm-57	7	84	cancer	cancer	NOUN
bptjm-57	7	85	is	be	AUX
bptjm-57	7	86	rather	rather	ADV
bptjm-57	7	87	complicated	complicated	ADJ
bptjm-57	7	88	.	.	PUNCT
bptjm-57	8	1	cancer	cancer	NOUN
bptjm-57	8	2	is	be	AUX
bptjm-57	8	3	not	not	PART
bptjm-57	8	4	merely	merely	ADV
bptjm-57	8	5	one	one	NUM
bptjm-57	8	6	disease	disease	NOUN
bptjm-57	8	7	but	but	CCONJ
bptjm-57	8	8	rather	rather	ADV
bptjm-57	8	9	a	a	DET
bptjm-57	8	10	group	group	NOUN
bptjm-57	8	11	of	of	ADP
bptjm-57	8	12	diseases	disease	NOUN
bptjm-57	8	13	that	that	PRON
bptjm-57	8	14	consist	consist	VERB
bptjm-57	8	15	of	of	ADP
bptjm-57	8	16	various	various	ADJ
bptjm-57	8	17	classi	classi	PROPN
bptjm-57	8	18	�	�	PROPN
bptjm-57	8	19	cations	cation	NOUN
bptjm-57	8	20	,	,	PUNCT
bptjm-57	8	21	with	with	ADP
bptjm-57	8	22	each	each	DET
bptjm-57	8	23	cancer	cancer	NOUN
bptjm-57	8	24	generally	generally	ADV
bptjm-57	8	25	named	name	VERB
bptjm-57	8	26	after	after	ADP
bptjm-57	8	27	the	the	DET
bptjm-57	8	28	body	body	NOUN
bptjm-57	8	29	part	part	NOUN
bptjm-57	8	30	where	where	SCONJ
bptjm-57	8	31	the	the	DET
bptjm-57	8	32	abnormal	abnormal	ADJ
bptjm-57	8	33	cell	cell	NOUN
bptjm-57	8	34	growth	growth	NOUN
bptjm-57	8	35	begins	begin	VERB
bptjm-57	8	36	.	.	PUNCT
bptjm-57	9	1	the	the	DET
bptjm-57	9	2	various	various	ADJ
bptjm-57	9	3	types	type	NOUN
bptjm-57	9	4	of	of	ADP
bptjm-57	9	5	cancers	cancer	NOUN
bptjm-57	9	6	share	share	VERB
bptjm-57	9	7	certain	certain	ADJ
bptjm-57	9	8	hallmarks	hallmark	NOUN
bptjm-57	9	9	,	,	PUNCT
bptjm-57	9	10	such	such	ADJ
bptjm-57	9	11	as	as	ADP
bptjm-57	9	12	invasion	invasion	NOUN
bptjm-57	9	13	and	and	CCONJ
bptjm-57	9	14	metastasis	metastasis	NOUN
bptjm-57	9	15	,	,	PUNCT
bptjm-57	9	16	tumoral	tumoral	ADJ
bptjm-57	9	17	angiogenesis	angiogenesis	NOUN
bptjm-57	9	18	,	,	PUNCT
bptjm-57	9	19	and	and	CCONJ
bptjm-57	9	20	the	the	DET
bptjm-57	9	21	evasion	evasion	NOUN
bptjm-57	9	22	of	of	ADP
bptjm-57	9	23	apoptosis	apoptosis	NOUN
bptjm-57	9	24	.	.	PUNCT
bptjm-57	10	1	the	the	DET
bptjm-57	10	2	most	most	ADV
bptjm-57	10	3	common	common	ADJ
bptjm-57	10	4	cancers	cancer	NOUN
bptjm-57	10	5	in	in	ADP
bptjm-57	10	6	the	the	DET
bptjm-57	10	7	u.s	u.s	PROPN
bptjm-57	10	8	.	.	PROPN
bptjm-57	10	9	are	be	AUX
bptjm-57	10	10	breast	breast	NOUN
bptjm-57	10	11	,	,	PUNCT
bptjm-57	10	12	prostate	prostate	NOUN
bptjm-57	10	13	,	,	PUNCT
bptjm-57	10	14	and	and	CCONJ
bptjm-57	10	15	lung	lung	NOUN
bptjm-57	10	16	cancer	cancer	NOUN
bptjm-57	10	17	,	,	PUNCT
bptjm-57	10	18	but	but	CCONJ
bptjm-57	10	19	it	it	PRON
bptjm-57	10	20	can	can	AUX
bptjm-57	10	21	also	also	ADV
bptjm-57	10	22	occur	occur	VERB
bptjm-57	10	23	in	in	ADP
bptjm-57	10	24	skin	skin	NOUN
bptjm-57	10	25	cells	cell	NOUN
bptjm-57	10	26	or	or	CCONJ
bptjm-57	10	27	bone	bone	NOUN
bptjm-57	10	28	tissues.3	tissues.3	NOUN
bptjm-57	10	29	the	the	DET
bptjm-57	10	30	problem	problem	NOUN
bptjm-57	10	31	is	be	AUX
bptjm-57	10	32	that	that	SCONJ
bptjm-57	10	33	no	no	DET
bptjm-57	10	34	two	two	NUM
bptjm-57	10	35	cancers	cancer	NOUN
bptjm-57	10	36	are	be	AUX
bptjm-57	10	37	exactly	exactly	ADV
bptjm-57	10	38	alike	alike	ADV
bptjm-57	10	39	,	,	PUNCT
bptjm-57	10	40	even	even	ADV
bptjm-57	10	41	if	if	SCONJ
bptjm-57	10	42	they	they	PRON
bptjm-57	10	43	are	be	AUX
bptjm-57	10	44	classi	classi	ADJ
bptjm-57	10	45	�	�	PROPN
bptjm-57	10	46	ed	ed	PROPN
bptjm-57	10	47	as	as	ADP
bptjm-57	10	48	the	the	DET
bptjm-57	10	49	same	same	ADJ
bptjm-57	10	50	type	type	NOUN
bptjm-57	10	51	or	or	CCONJ
bptjm-57	10	52	occur	occur	VERB
bptjm-57	10	53	in	in	ADP
bptjm-57	10	54	the	the	DET
bptjm-57	10	55	same	same	ADJ
bptjm-57	10	56	body	body	NOUN
bptjm-57	10	57	tissue	tissue	NOUN
bptjm-57	10	58	.	.	PUNCT
bptjm-57	11	1	each	each	DET
bptjm-57	11	2	individual	individual	NOUN
bptjm-57	11	3	’s	’s	PART
bptjm-57	11	4	cancer	cancer	NOUN
bptjm-57	11	5	contains	contain	VERB
bptjm-57	11	6	unique	unique	ADJ
bptjm-57	11	7	combinations	combination	NOUN
bptjm-57	11	8	of	of	ADP
bptjm-57	11	9	genetic	genetic	ADJ
bptjm-57	11	10	changes	change	NOUN
bptjm-57	11	11	,	,	PUNCT
bptjm-57	11	12	which	which	PRON
bptjm-57	11	13	can	can	AUX
bptjm-57	11	14	a	a	DET
bptjm-57	11	15	�	�	NOUN
bptjm-57	11	16	ect	ect	VERB
bptjm-57	11	17	a	a	DET
bptjm-57	11	18	patient	patient	NOUN
bptjm-57	11	19	’s	’s	PART
bptjm-57	11	20	response	response	NOUN
bptjm-57	11	21	to	to	ADP
bptjm-57	11	22	speci	speci	PROPN
bptjm-57	11	23	�	�	PROPN
bptjm-57	11	24	c	c	PART
bptjm-57	11	25	treatments.4	treatments.4	ADJ
bptjm-57	11	26	researchers	researcher	NOUN
bptjm-57	11	27	from	from	ADP
bptjm-57	11	28	the	the	DET
bptjm-57	11	29	wellcome	wellcome	PROPN
bptjm-57	11	30	trust	trust	PROPN
bptjm-57	11	31	sanger	sanger	PROPN
bptjm-57	11	32	institute	institute	PROPN
bptjm-57	11	33	analyzed	analyze	VERB
bptjm-57	11	34	4,938,362	4,938,362	NUM
bptjm-57	11	35	mutations	mutation	NOUN
bptjm-57	11	36	from	from	ADP
bptjm-57	11	37	7,042	7,042	NUM
bptjm-57	11	38	cancers	cancer	NOUN
bptjm-57	11	39	,	,	PUNCT
bptjm-57	11	40	investigated	investigate	VERB
bptjm-57	11	41	the	the	DET
bptjm-57	11	42	genomic	genomic	ADJ
bptjm-57	11	43	dynamics	dynamic	NOUN
bptjm-57	11	44	of	of	ADP
bptjm-57	11	45	tumors	tumor	NOUN
bptjm-57	11	46	undergoing	undergo	VERB
bptjm-57	11	47	exogenous	exogenous	ADJ
bptjm-57	11	48	and	and	CCONJ
bptjm-57	11	49	endogenous	endogenous	ADJ
bptjm-57	11	50	mutational	mutational	ADJ
bptjm-57	11	51	processes	process	NOUN
bptjm-57	11	52	,	,	PUNCT
bptjm-57	11	53	and	and	CCONJ
bptjm-57	11	54	extracted	extract	VERB
bptjm-57	11	55	more	more	ADJ
bptjm-57	11	56	than	than	ADP
bptjm-57	11	57	20	20	NUM
bptjm-57	11	58	distinct	distinct	ADJ
bptjm-57	11	59	mutational	mutational	NOUN
bptjm-57	11	60	signatures.5	signatures.5	PROPN
bptjm-57	11	61	these	these	DET
bptjm-57	11	62	statistics	statistic	NOUN
bptjm-57	11	63	highlight	highlight	VERB
bptjm-57	11	64	the	the	DET
bptjm-57	11	65	vast	vast	ADJ
bptjm-57	11	66	possibilities	possibility	NOUN
bptjm-57	11	67	of	of	ADP
bptjm-57	11	68	genetic	genetic	ADJ
bptjm-57	11	69	alterations	alteration	NOUN
bptjm-57	11	70	a	a	DET
bptjm-57	11	71	cancer	cancer	NOUN
bptjm-57	11	72	cell	cell	NOUN
bptjm-57	11	73	could	could	AUX
bptjm-57	11	74	undergo	undergo	VERB
bptjm-57	11	75	,	,	PUNCT
bptjm-57	11	76	leading	lead	VERB
bptjm-57	11	77	to	to	ADP
bptjm-57	11	78	more	more	ADJ
bptjm-57	11	79	variation	variation	NOUN
bptjm-57	11	80	between	between	ADP
bptjm-57	11	81	and	and	CCONJ
bptjm-57	11	82	within	within	ADP
bptjm-57	11	83	tumors	tumor	NOUN
bptjm-57	11	84	.	.	PUNCT
bptjm-57	12	1	factors	factor	NOUN
bptjm-57	12	2	such	such	ADJ
bptjm-57	12	3	as	as	ADP
bptjm-57	12	4	family	family	NOUN
bptjm-57	12	5	history	history	NOUN
bptjm-57	12	6	and	and	CCONJ
bptjm-57	12	7	lifestyle	lifestyle	NOUN
bptjm-57	12	8	habits	habit	NOUN
bptjm-57	12	9	,	,	PUNCT
bptjm-57	12	10	especially	especially	ADV
bptjm-57	12	11	smoking	smoking	NOUN
bptjm-57	12	12	,	,	PUNCT
bptjm-57	12	13	also	also	ADV
bptjm-57	12	14	contribute	contribute	VERB
bptjm-57	12	15	to	to	ADP
bptjm-57	12	16	the	the	DET
bptjm-57	12	17	uniqueness	uniqueness	NOUN
bptjm-57	12	18	of	of	ADP
bptjm-57	12	19	each	each	DET
bptjm-57	12	20	individual	individual	NOUN
bptjm-57	12	21	’s	’s	PART
bptjm-57	12	22	tumor	tumor	NOUN
bptjm-57	12	23	.	.	PUNCT
bptjm-57	13	1	hence	hence	ADV
bptjm-57	13	2	,	,	PUNCT
bptjm-57	13	3	this	this	DET
bptjm-57	13	4	individuality	individuality	NOUN
bptjm-57	13	5	of	of	ADP
bptjm-57	13	6	cancer	cancer	NOUN
bptjm-57	13	7	,	,	PUNCT
bptjm-57	13	8	also	also	ADV
bptjm-57	13	9	known	know	VERB
bptjm-57	13	10	as	as	ADP
bptjm-57	13	11	tumor	tumor	NOUN
bptjm-57	13	12	heterogeneity	heterogeneity	NOUN
bptjm-57	13	13	,	,	PUNCT
bptjm-57	13	14	complicates	complicate	VERB
bptjm-57	13	15	its	its	PRON
bptjm-57	13	16	treatment	treatment	NOUN
bptjm-57	13	17	.	.	PUNCT
bptjm-57	14	1	tumor	tumor	PROPN
bptjm-57	14	2	heterogeneity	heterogeneity	PROPN
bptjm-57	14	3	refers	refer	VERB
bptjm-57	14	4	to	to	ADP
bptjm-57	14	5	the	the	DET
bptjm-57	14	6	disparities	disparity	NOUN
bptjm-57	14	7	between	between	ADP
bptjm-57	14	8	tumors	tumor	NOUN
bptjm-57	14	9	of	of	ADP
bptjm-57	14	10	the	the	DET
bptjm-57	14	11	same	same	ADJ
bptjm-57	14	12	type	type	NOUN
bptjm-57	14	13	in	in	ADP
bptjm-57	14	14	di	di	NOUN
bptjm-57	14	15	�	�	PROPN
bptjm-57	14	16	erent	erent	NOUN
bptjm-57	14	17	patients	patient	NOUN
bptjm-57	14	18	,	,	PUNCT
bptjm-57	14	19	between	between	ADP
bptjm-57	14	20	cancer	cancer	NOUN
bptjm-57	14	21	cells	cell	NOUN
bptjm-57	14	22	within	within	ADP
bptjm-57	14	23	a	a	DET
bptjm-57	14	24	single	single	ADJ
bptjm-57	14	25	tumor	tumor	NOUN
bptjm-57	14	26	,	,	PUNCT
bptjm-57	14	27	or	or	CCONJ
bptjm-57	14	28	between	between	ADP
bptjm-57	14	29	primary	primary	ADJ
bptjm-57	14	30	and	and	CCONJ
bptjm-57	14	31	secondary	secondary	ADJ
bptjm-57	14	32	tumors	tumor	NOUN
bptjm-57	14	33	.	.	PUNCT
bptjm-57	15	1	intratumor	intratumor	PROPN
bptjm-57	15	2	heterogeneity	heterogeneity	PROPN
bptjm-57	15	3	(	(	PUNCT
bptjm-57	15	4	ith	ith	PROPN
bptjm-57	15	5	)	)	PUNCT
bptjm-57	15	6	,	,	PUNCT
bptjm-57	15	7	which	which	PRON
bptjm-57	15	8	refers	refer	VERB
bptjm-57	15	9	to	to	ADP
bptjm-57	15	10	the	the	DET
bptjm-57	15	11	presence	presence	NOUN
bptjm-57	15	12	of	of	ADP
bptjm-57	15	13	a	a	DET
bptjm-57	15	14	diverse	diverse	ADJ
bptjm-57	15	15	cell	cell	NOUN
bptjm-57	15	16	population	population	NOUN
bptjm-57	15	17	within	within	ADP
bptjm-57	15	18	a	a	DET
bptjm-57	15	19	single	single	ADJ
bptjm-57	15	20	tumor	tumor	NOUN
bptjm-57	15	21	,	,	PUNCT
bptjm-57	15	22	poses	pose	VERB
bptjm-57	15	23	the	the	DET
bptjm-57	15	24	greatest	great	ADJ
bptjm-57	15	25	challenge	challenge	NOUN
bptjm-57	15	26	to	to	ADP
bptjm-57	15	27	cancer	cancer	NOUN
bptjm-57	15	28	treatment	treatment	NOUN
bptjm-57	15	29	today	today	NOUN
bptjm-57	15	30	.	.	PUNCT
bptjm-57	16	1	it	it	PRON
bptjm-57	16	2	can	can	AUX
bptjm-57	16	3	be	be	AUX
bptjm-57	16	4	further	far	ADV
bptjm-57	16	5	distinguished	distinguish	VERB
bptjm-57	16	6	by	by	ADP
bptjm-57	16	7	genetic	genetic	ADJ
bptjm-57	16	8	and	and	CCONJ
bptjm-57	16	9	phenotypic	phenotypic	ADJ
bptjm-57	16	10	properties	property	NOUN
bptjm-57	16	11	,	,	PUNCT
bptjm-57	16	12	which	which	PRON
bptjm-57	16	13	vary	vary	VERB
bptjm-57	16	14	and	and	CCONJ
bptjm-57	16	15	a	a	DET
bptjm-57	16	16	�	�	NOUN
bptjm-57	16	17	ect	ect	VERB
bptjm-57	16	18	the	the	DET
bptjm-57	16	19	behaviors	behavior	NOUN
bptjm-57	16	20	of	of	ADP
bptjm-57	16	21	di	di	PROPN
bptjm-57	16	22	�	�	PROPN
bptjm-57	16	23	erent	erent	NOUN
bptjm-57	16	24	tumor	tumor	NOUN
bptjm-57	16	25	cell	cell	NOUN
bptjm-57	16	26	populations	population	NOUN
bptjm-57	16	27	.	.	PUNCT
bptjm-57	17	1	one	one	NUM
bptjm-57	17	2	system	system	NOUN
bptjm-57	17	3	of	of	ADP
bptjm-57	17	4	tumor	tumor	NOUN
bptjm-57	17	5	cell	cell	NOUN
bptjm-57	17	6	analysis	analysis	NOUN
bptjm-57	17	7	is	be	AUX
bptjm-57	17	8	the	the	DET
bptjm-57	17	9	clustering	clustering	NOUN
bptjm-57	17	10	,	,	PUNCT
bptjm-57	17	11	classi	classi	NOUN
bptjm-57	17	12	�	�	NOUN
bptjm-57	17	13	cation	cation	NOUN
bptjm-57	17	14	,	,	PUNCT
bptjm-57	17	15	and	and	CCONJ
bptjm-57	17	16	sorting	sort	VERB
bptjm-57	17	17	tree	tree	NOUN
bptjm-57	17	18	(	(	PUNCT
bptjm-57	17	19	ccast	ccast	NOUN
bptjm-57	17	20	)	)	PUNCT
bptjm-57	17	21	,	,	PUNCT
bptjm-57	17	22	which	which	PRON
bptjm-57	17	23	aims	aim	VERB
bptjm-57	17	24	to	to	PART
bptjm-57	17	25	target	target	VERB
bptjm-57	17	26	speci	speci	PROPN
bptjm-57	17	27	�	�	PROPN
bptjm-57	17	28	c	c	PROPN
bptjm-57	17	29	characteristics	characteristic	NOUN
bptjm-57	17	30	that	that	PRON
bptjm-57	17	31	can	can	AUX
bptjm-57	17	32	vary	vary	VERB
bptjm-57	17	33	widely	widely	ADV
bptjm-57	17	34	berkeley	berkeley	PROPN
bptjm-57	17	35	pharma	pharma	PROPN
bptjm-57	17	36	tech	tech	NOUN
bptjm-57	17	37	journal	journal	NOUN
bptjm-57	17	38	of	of	ADP
bptjm-57	17	39	medicine	medicine	NOUN
bptjm-57	17	40	|	|	ADV
bptjm-57	17	41	84	84	NUM
bptjm-57	17	42	within	within	ADP
bptjm-57	17	43	malignant	malignant	ADJ
bptjm-57	17	44	cells	cell	NOUN
bptjm-57	17	45	.	.	PUNCT
bptjm-57	18	1	it	it	PRON
bptjm-57	18	2	analyzes	analyze	VERB
bptjm-57	18	3	the	the	DET
bptjm-57	18	4	genetic	genetic	ADJ
bptjm-57	18	5	and	and	CCONJ
bptjm-57	18	6	phenotypic	phenotypic	ADJ
bptjm-57	18	7	variations	variation	NOUN
bptjm-57	18	8	within	within	ADP
bptjm-57	18	9	tumor	tumor	NOUN
bptjm-57	18	10	cells	cell	NOUN
bptjm-57	18	11	by	by	ADP
bptjm-57	18	12	distinguishing	distinguish	VERB
bptjm-57	18	13	homogeneous	homogeneous	ADJ
bptjm-57	18	14	subpopulations	subpopulation	NOUN
bptjm-57	18	15	within	within	ADP
bptjm-57	18	16	a	a	DET
bptjm-57	18	17	mixed	mixed	ADJ
bptjm-57	18	18	group	group	NOUN
bptjm-57	18	19	of	of	ADP
bptjm-57	18	20	single	single	ADJ
bptjm-57	18	21	cells	cell	NOUN
bptjm-57	18	22	.	.	PUNCT
bptjm-57	19	1	for	for	ADP
bptjm-57	19	2	example	example	NOUN
bptjm-57	19	3	,	,	PUNCT
bptjm-57	19	4	ccast	ccast	PROPN
bptjm-57	19	5	was	be	AUX
bptjm-57	19	6	applied	apply	VERB
bptjm-57	19	7	to	to	ADP
bptjm-57	19	8	a	a	DET
bptjm-57	19	9	breast	breast	NOUN
bptjm-57	19	10	cancer	cancer	NOUN
bptjm-57	19	11	cell	cell	NOUN
bptjm-57	19	12	line	line	NOUN
bptjm-57	19	13	and	and	CCONJ
bptjm-57	19	14	identi	identi	NOUN
bptjm-57	19	15	�	�	NOUN
bptjm-57	19	16	ed	ed	PROPN
bptjm-57	19	17	at	at	ADP
bptjm-57	19	18	least	least	ADJ
bptjm-57	19	19	�	�	NOUN
bptjm-57	19	20	ve	ve	VERB
bptjm-57	19	21	distinct	distinct	ADJ
bptjm-57	19	22	cell	cell	NOUN
bptjm-57	19	23	types	type	NOUN
bptjm-57	19	24	,	,	PUNCT
bptjm-57	19	25	which	which	PRON
bptjm-57	19	26	helped	help	VERB
bptjm-57	19	27	elucidate	elucidate	VERB
bptjm-57	19	28	which	which	DET
bptjm-57	19	29	tumor	tumor	NOUN
bptjm-57	19	30	cell	cell	NOUN
bptjm-57	19	31	subpopulations	subpopulation	NOUN
bptjm-57	19	32	warranted	warrant	VERB
bptjm-57	19	33	further	far	ADV
bptjm-57	19	34	investigation.6	investigation.6	NOUN
bptjm-57	19	35	thus	thus	ADV
bptjm-57	19	36	,	,	PUNCT
bptjm-57	19	37	utilizing	utilize	VERB
bptjm-57	19	38	such	such	ADJ
bptjm-57	19	39	diagnostic	diagnostic	ADJ
bptjm-57	19	40	guidelines	guideline	NOUN
bptjm-57	19	41	to	to	PART
bptjm-57	19	42	identify	identify	VERB
bptjm-57	19	43	variations	variation	NOUN
bptjm-57	19	44	in	in	ADP
bptjm-57	19	45	genetic	genetic	ADJ
bptjm-57	19	46	and	and	CCONJ
bptjm-57	19	47	phenotypic	phenotypic	ADJ
bptjm-57	19	48	properties	property	NOUN
bptjm-57	19	49	is	be	AUX
bptjm-57	19	50	bene	bene	NOUN
bptjm-57	19	51	�	�	NOUN
bptjm-57	19	52	cial	cial	NOUN
bptjm-57	19	53	as	as	ADP
bptjm-57	19	54	a	a	DET
bptjm-57	19	55	prognostic	prognostic	ADJ
bptjm-57	19	56	indicator	indicator	NOUN
bptjm-57	19	57	to	to	PART
bptjm-57	19	58	better	well	ADV
bptjm-57	19	59	predict	predict	VERB
bptjm-57	19	60	tumor	tumor	NOUN
bptjm-57	19	61	response	response	NOUN
bptjm-57	19	62	and	and	CCONJ
bptjm-57	19	63	guide	guide	VERB
bptjm-57	19	64	therapeutic	therapeutic	ADJ
bptjm-57	19	65	precision	precision	NOUN
bptjm-57	19	66	strategies	strategy	NOUN
bptjm-57	19	67	.	.	PUNCT
bptjm-57	20	1	associated	associate	VERB
bptjm-57	20	2	with	with	ADP
bptjm-57	20	3	poor	poor	ADJ
bptjm-57	20	4	prognosis	prognosis	NOUN
bptjm-57	20	5	,	,	PUNCT
bptjm-57	20	6	outcome	outcome	NOUN
bptjm-57	20	7	,	,	PUNCT
bptjm-57	20	8	and	and	CCONJ
bptjm-57	20	9	overall	overall	ADJ
bptjm-57	20	10	survival	survival	NOUN
bptjm-57	20	11	,	,	PUNCT
bptjm-57	20	12	ith	ith	PROPN
bptjm-57	20	13	is	be	AUX
bptjm-57	20	14	thought	think	VERB
bptjm-57	20	15	to	to	PART
bptjm-57	20	16	be	be	AUX
bptjm-57	20	17	a	a	DET
bptjm-57	20	18	signi	signi	ADJ
bptjm-57	20	19	�	�	NOUN
bptjm-57	20	20	cant	cant	NOUN
bptjm-57	20	21	factor	factor	NOUN
bptjm-57	20	22	in	in	ADP
bptjm-57	20	23	causing	cause	VERB
bptjm-57	20	24	therapeutic	therapeutic	ADJ
bptjm-57	20	25	resistance	resistance	NOUN
bptjm-57	20	26	and	and	CCONJ
bptjm-57	20	27	treatment	treatment	NOUN
bptjm-57	20	28	failure.7	failure.7	NOUN
bptjm-57	20	29	tailoring	tailor	VERB
bptjm-57	20	30	e	e	NOUN
bptjm-57	20	31	�	�	NOUN
bptjm-57	20	32	ective	ective	ADJ
bptjm-57	20	33	cancer	cancer	NOUN
bptjm-57	20	34	treatments	treatment	NOUN
bptjm-57	20	35	is	be	AUX
bptjm-57	20	36	also	also	ADV
bptjm-57	20	37	challenging	challenge	VERB
bptjm-57	20	38	due	due	ADJ
bptjm-57	20	39	to	to	ADP
bptjm-57	20	40	the	the	DET
bptjm-57	20	41	unique	unique	ADJ
bptjm-57	20	42	response	response	NOUN
bptjm-57	20	43	patterns	pattern	NOUN
bptjm-57	20	44	exhibited	exhibit	VERB
bptjm-57	20	45	by	by	ADP
bptjm-57	20	46	individual	individual	ADJ
bptjm-57	20	47	patients	patient	NOUN
bptjm-57	20	48	.	.	PUNCT
bptjm-57	21	1	thus	thus	ADV
bptjm-57	21	2	,	,	PUNCT
bptjm-57	21	3	understanding	understand	VERB
bptjm-57	21	4	tumor	tumor	NOUN
bptjm-57	21	5	heterogeneity	heterogeneity	NOUN
bptjm-57	21	6	is	be	AUX
bptjm-57	21	7	crucial	crucial	ADJ
bptjm-57	21	8	in	in	ADP
bptjm-57	21	9	treating	treat	VERB
bptjm-57	21	10	cancer	cancer	NOUN
bptjm-57	21	11	and	and	CCONJ
bptjm-57	21	12	overcoming	overcome	VERB
bptjm-57	21	13	therapeutic	therapeutic	ADJ
bptjm-57	21	14	resistance	resistance	NOUN
bptjm-57	21	15	.	.	PUNCT
bptjm-57	22	1	initially	initially	ADV
bptjm-57	22	2	,	,	PUNCT
bptjm-57	22	3	the	the	DET
bptjm-57	22	4	primary	primary	ADJ
bptjm-57	22	5	source	source	NOUN
bptjm-57	22	6	of	of	ADP
bptjm-57	22	7	tumor	tumor	NOUN
bptjm-57	22	8	heterogeneity	heterogeneity	NOUN
bptjm-57	22	9	was	be	AUX
bptjm-57	22	10	thought	think	VERB
bptjm-57	22	11	to	to	PART
bptjm-57	22	12	be	be	AUX
bptjm-57	22	13	genetic	genetic	ADJ
bptjm-57	22	14	or	or	CCONJ
bptjm-57	22	15	epigenetic	epigenetic	ADJ
bptjm-57	22	16	alterations	alteration	NOUN
bptjm-57	22	17	as	as	SCONJ
bptjm-57	22	18	scientists	scientist	NOUN
bptjm-57	22	19	were	be	AUX
bptjm-57	22	20	beginning	begin	VERB
bptjm-57	22	21	to	to	PART
bptjm-57	22	22	understand	understand	VERB
bptjm-57	22	23	the	the	DET
bptjm-57	22	24	impact	impact	NOUN
bptjm-57	22	25	of	of	ADP
bptjm-57	22	26	tumor	tumor	NOUN
bptjm-57	22	27	heterogeneity.8	heterogeneity.8	VERB
bptjm-57	22	28	while	while	SCONJ
bptjm-57	22	29	this	this	DET
bptjm-57	22	30	understanding	understanding	NOUN
bptjm-57	22	31	holds	hold	VERB
bptjm-57	22	32	some	some	DET
bptjm-57	22	33	truth	truth	NOUN
bptjm-57	22	34	,	,	PUNCT
bptjm-57	22	35	more	more	ADJ
bptjm-57	22	36	studies	study	NOUN
bptjm-57	22	37	in	in	ADP
bptjm-57	22	38	recent	recent	ADJ
bptjm-57	22	39	years	year	NOUN
bptjm-57	22	40	have	have	AUX
bptjm-57	22	41	observed	observe	VERB
bptjm-57	22	42	tumor	tumor	NOUN
bptjm-57	22	43	heterogeneity	heterogeneity	NOUN
bptjm-57	22	44	of	of	ADP
bptjm-57	22	45	varying	vary	VERB
bptjm-57	22	46	types	type	NOUN
bptjm-57	22	47	,	,	PUNCT
bptjm-57	22	48	such	such	ADJ
bptjm-57	22	49	as	as	ADP
bptjm-57	22	50	metabolic	metabolic	NOUN
bptjm-57	22	51	,	,	PUNCT
bptjm-57	22	52	cellular	cellular	ADJ
bptjm-57	22	53	,	,	PUNCT
bptjm-57	22	54	spatial	spatial	ADJ
bptjm-57	22	55	,	,	PUNCT
bptjm-57	22	56	and	and	CCONJ
bptjm-57	22	57	more	more	ADJ
bptjm-57	22	58	.	.	PUNCT
bptjm-57	23	1	however	however	ADV
bptjm-57	23	2	,	,	PUNCT
bptjm-57	23	3	despite	despite	SCONJ
bptjm-57	23	4	the	the	DET
bptjm-57	23	5	e	e	PROPN
bptjm-57	23	6	�	�	NOUN
bptjm-57	23	7	orts	ort	NOUN
bptjm-57	23	8	of	of	ADP
bptjm-57	23	9	current	current	ADJ
bptjm-57	23	10	common	common	ADJ
bptjm-57	23	11	cancer	cancer	NOUN
bptjm-57	23	12	treatments	treatment	NOUN
bptjm-57	23	13	to	to	PART
bptjm-57	23	14	address	address	VERB
bptjm-57	23	15	tumor	tumor	NOUN
bptjm-57	23	16	heterogeneity	heterogeneity	NOUN
bptjm-57	23	17	,	,	PUNCT
bptjm-57	23	18	there	there	PRON
bptjm-57	23	19	is	be	VERB
bptjm-57	23	20	still	still	ADV
bptjm-57	23	21	a	a	DET
bptjm-57	23	22	signi	signi	ADJ
bptjm-57	23	23	�	�	NOUN
bptjm-57	23	24	cant	cant	VERB
bptjm-57	23	25	risk	risk	NOUN
bptjm-57	23	26	of	of	ADP
bptjm-57	23	27	cancer	cancer	NOUN
bptjm-57	23	28	cells	cell	NOUN
bptjm-57	23	29	resisting	resist	VERB
bptjm-57	23	30	treatments	treatment	NOUN
bptjm-57	23	31	and	and	CCONJ
bptjm-57	23	32	therapies	therapy	NOUN
bptjm-57	23	33	through	through	ADP
bptjm-57	23	34	mutations	mutation	NOUN
bptjm-57	23	35	,	,	PUNCT
bptjm-57	23	36	selective	selective	ADJ
bptjm-57	23	37	pressure	pressure	NOUN
bptjm-57	23	38	,	,	PUNCT
bptjm-57	23	39	and	and	CCONJ
bptjm-57	23	40	other	other	ADJ
bptjm-57	23	41	adaptation	adaptation	NOUN
bptjm-57	23	42	processes	process	NOUN
bptjm-57	23	43	,	,	PUNCT
bptjm-57	23	44	setting	set	VERB
bptjm-57	23	45	back	back	ADP
bptjm-57	23	46	the	the	DET
bptjm-57	23	47	development	development	NOUN
bptjm-57	23	48	of	of	ADP
bptjm-57	23	49	more	more	ADJ
bptjm-57	23	50	e	e	NOUN
bptjm-57	23	51	�	�	NOUN
bptjm-57	23	52	ective	ective	ADJ
bptjm-57	23	53	cancer	cancer	NOUN
bptjm-57	23	54	treatments	treatment	NOUN
bptjm-57	23	55	.	.	PUNCT
bptjm-57	24	1	the	the	DET
bptjm-57	24	2	latest	late	ADJ
bptjm-57	24	3	endeavors	endeavor	NOUN
bptjm-57	24	4	have	have	AUX
bptjm-57	24	5	focused	focus	VERB
bptjm-57	24	6	on	on	ADP
bptjm-57	24	7	developing	develop	VERB
bptjm-57	24	8	novel	novel	ADJ
bptjm-57	24	9	strategies	strategy	NOUN
bptjm-57	24	10	to	to	PART
bptjm-57	24	11	overcome	overcome	VERB
bptjm-57	24	12	the	the	DET
bptjm-57	24	13	challenges	challenge	NOUN
bptjm-57	24	14	posed	pose	VERB
bptjm-57	24	15	by	by	ADP
bptjm-57	24	16	tumor	tumor	NOUN
bptjm-57	24	17	heterogeneity	heterogeneity	NOUN
bptjm-57	24	18	and	and	CCONJ
bptjm-57	24	19	combat	combat	NOUN
bptjm-57	24	20	treatment	treatment	NOUN
bptjm-57	24	21	resistance	resistance	NOUN
bptjm-57	24	22	and	and	CCONJ
bptjm-57	24	23	disease	disease	NOUN
bptjm-57	24	24	progression	progression	NOUN
bptjm-57	24	25	.	.	PUNCT
bptjm-57	25	1	some	some	PRON
bptjm-57	25	2	of	of	ADP
bptjm-57	25	3	these	these	DET
bptjm-57	25	4	treatments	treatment	NOUN
bptjm-57	25	5	target	target	VERB
bptjm-57	25	6	unique	unique	ADJ
bptjm-57	25	7	features	feature	NOUN
bptjm-57	25	8	of	of	ADP
bptjm-57	25	9	the	the	DET
bptjm-57	25	10	tumor	tumor	NOUN
bptjm-57	25	11	,	,	PUNCT
bptjm-57	25	12	allowing	allow	VERB
bptjm-57	25	13	for	for	ADP
bptjm-57	25	14	a	a	DET
bptjm-57	25	15	more	more	ADV
bptjm-57	25	16	precise	precise	ADJ
bptjm-57	25	17	and	and	CCONJ
bptjm-57	25	18	personalized	personalized	ADJ
bptjm-57	25	19	approach	approach	NOUN
bptjm-57	25	20	.	.	PUNCT
bptjm-57	26	1	we	we	PRON
bptjm-57	26	2	reviewed	review	VERB
bptjm-57	26	3	recent	recent	ADJ
bptjm-57	26	4	scienti	scienti	NOUN
bptjm-57	26	5	�	�	PROPN
bptjm-57	26	6	c	c	ADJ
bptjm-57	26	7	literature	literature	NOUN
bptjm-57	26	8	for	for	ADP
bptjm-57	26	9	an	an	DET
bptjm-57	26	10	overview	overview	NOUN
bptjm-57	26	11	of	of	ADP
bptjm-57	26	12	tumor	tumor	NOUN
bptjm-57	26	13	heterogeneity	heterogeneity	NOUN
bptjm-57	26	14	,	,	PUNCT
bptjm-57	26	15	along	along	ADP
bptjm-57	26	16	with	with	ADP
bptjm-57	26	17	current	current	ADJ
bptjm-57	26	18	and	and	CCONJ
bptjm-57	26	19	potential	potential	ADJ
bptjm-57	26	20	cancer	cancer	NOUN
bptjm-57	26	21	treatments	treatment	NOUN
bptjm-57	26	22	that	that	PRON
bptjm-57	26	23	surmount	surmount	VERB
bptjm-57	26	24	its	its	PRON
bptjm-57	26	25	challenges	challenge	NOUN
bptjm-57	26	26	.	.	PUNCT
bptjm-57	27	1	in	in	ADP
bptjm-57	27	2	addition	addition	NOUN
bptjm-57	27	3	,	,	PUNCT
bptjm-57	27	4	we	we	PRON
bptjm-57	27	5	examined	examine	VERB
bptjm-57	27	6	recent	recent	ADJ
bptjm-57	27	7	and	and	CCONJ
bptjm-57	27	8	ongoing	ongoing	ADJ
bptjm-57	27	9	clinical	clinical	ADJ
bptjm-57	27	10	trials	trial	NOUN
bptjm-57	27	11	to	to	PART
bptjm-57	27	12	analyze	analyze	VERB
bptjm-57	27	13	the	the	DET
bptjm-57	27	14	purpose	purpose	NOUN
bptjm-57	27	15	and	and	CCONJ
bptjm-57	27	16	design	design	NOUN
bptjm-57	27	17	of	of	ADP
bptjm-57	27	18	the	the	DET
bptjm-57	27	19	studies	study	NOUN
bptjm-57	27	20	and	and	CCONJ
bptjm-57	27	21	gain	gain	VERB
bptjm-57	27	22	more	more	ADJ
bptjm-57	27	23	information	information	NOUN
bptjm-57	27	24	on	on	ADP
bptjm-57	27	25	the	the	DET
bptjm-57	27	26	signi	signi	PROPN
bptjm-57	27	27	�	�	PROPN
bptjm-57	27	28	cance	cance	NOUN
bptjm-57	27	29	of	of	ADP
bptjm-57	27	30	their	their	PRON
bptjm-57	27	31	results	result	NOUN
bptjm-57	27	32	.	.	PUNCT
bptjm-57	28	1	through	through	ADP
bptjm-57	28	2	this	this	DET
bptjm-57	28	3	review	review	NOUN
bptjm-57	28	4	,	,	PUNCT
bptjm-57	28	5	we	we	PRON
bptjm-57	28	6	hope	hope	VERB
bptjm-57	28	7	to	to	PART
bptjm-57	28	8	provide	provide	VERB
bptjm-57	28	9	insight	insight	NOUN
bptjm-57	28	10	into	into	ADP
bptjm-57	28	11	the	the	DET
bptjm-57	28	12	causes	cause	NOUN
bptjm-57	28	13	and	and	CCONJ
bptjm-57	28	14	negative	negative	ADJ
bptjm-57	28	15	e	e	NOUN
bptjm-57	28	16	�	�	NOUN
bptjm-57	28	17	ects	ect	NOUN
bptjm-57	28	18	of	of	ADP
bptjm-57	28	19	berkeley	berkeley	PROPN
bptjm-57	28	20	pharma	pharma	PROPN
bptjm-57	28	21	tech	tech	NOUN
bptjm-57	28	22	journal	journal	NOUN
bptjm-57	28	23	of	of	ADP
bptjm-57	28	24	medicine	medicine	NOUN
bptjm-57	28	25	|	|	ADV
bptjm-57	28	26	85	85	NUM
bptjm-57	28	27	tumor	tumor	NOUN
bptjm-57	28	28	heterogeneity	heterogeneity	NOUN
bptjm-57	28	29	on	on	ADP
bptjm-57	28	30	individual	individual	ADJ
bptjm-57	28	31	cancer	cancer	NOUN
bptjm-57	28	32	treatments	treatment	NOUN
bptjm-57	28	33	,	,	PUNCT
bptjm-57	28	34	along	along	ADP
bptjm-57	28	35	with	with	ADP
bptjm-57	28	36	potential	potential	ADJ
bptjm-57	28	37	strategies	strategy	NOUN
bptjm-57	28	38	that	that	PRON
bptjm-57	28	39	could	could	AUX
bptjm-57	28	40	overcome	overcome	VERB
bptjm-57	28	41	such	such	ADJ
bptjm-57	28	42	negative	negative	ADJ
bptjm-57	28	43	implications	implication	NOUN
bptjm-57	28	44	.	.	PUNCT
bptjm-57	29	1	2	2	X
bptjm-57	29	2	.	.	X
bptjm-57	29	3	tumor	tumor	NOUN
bptjm-57	29	4	heterogeneity	heterogeneity	NOUN
bptjm-57	29	5	2.1	2.1	NUM
bptjm-57	29	6	overview	overview	NOUN
bptjm-57	29	7	of	of	ADP
bptjm-57	29	8	tumor	tumor	NOUN
bptjm-57	29	9	heterogeneity	heterogeneity	NOUN
bptjm-57	29	10	tumor	tumor	NOUN
bptjm-57	29	11	heterogeneity	heterogeneity	NOUN
bptjm-57	29	12	has	have	VERB
bptjm-57	29	13	countless	countless	ADJ
bptjm-57	29	14	causes	cause	NOUN
bptjm-57	29	15	that	that	PRON
bptjm-57	29	16	complicates	complicate	VERB
bptjm-57	29	17	its	its	PRON
bptjm-57	29	18	prevention	prevention	NOUN
bptjm-57	29	19	methods	method	NOUN
bptjm-57	29	20	and	and	CCONJ
bptjm-57	29	21	treatment	treatment	NOUN
bptjm-57	29	22	,	,	PUNCT
bptjm-57	29	23	with	with	ADP
bptjm-57	29	24	two	two	NUM
bptjm-57	29	25	of	of	ADP
bptjm-57	29	26	its	its	PRON
bptjm-57	29	27	leading	lead	VERB
bptjm-57	29	28	causes	cause	NOUN
bptjm-57	29	29	being	be	AUX
bptjm-57	29	30	genetic	genetic	ADJ
bptjm-57	29	31	and	and	CCONJ
bptjm-57	29	32	environmental	environmental	ADJ
bptjm-57	29	33	factors	factor	NOUN
bptjm-57	29	34	.	.	PUNCT
bptjm-57	30	1	table	table	NOUN
bptjm-57	30	2	1	1	NUM
bptjm-57	30	3	expands	expand	VERB
bptjm-57	30	4	on	on	ADP
bptjm-57	30	5	the	the	DET
bptjm-57	30	6	causes	cause	NOUN
bptjm-57	30	7	of	of	ADP
bptjm-57	30	8	tumor	tumor	NOUN
bptjm-57	30	9	heterogeneity	heterogeneity	NOUN
bptjm-57	30	10	,	,	PUNCT
bptjm-57	30	11	including	include	VERB
bptjm-57	30	12	genetic	genetic	ADJ
bptjm-57	30	13	mutations	mutation	NOUN
bptjm-57	30	14	,	,	PUNCT
bptjm-57	30	15	clonal	clonal	ADJ
bptjm-57	30	16	evolution	evolution	NOUN
bptjm-57	30	17	,	,	PUNCT
bptjm-57	30	18	microenvironmental	microenvironmental	ADJ
bptjm-57	30	19	factors	factor	NOUN
bptjm-57	30	20	,	,	PUNCT
bptjm-57	30	21	and	and	CCONJ
bptjm-57	30	22	phenotypic	phenotypic	ADJ
bptjm-57	30	23	plasticity	plasticity	NOUN
bptjm-57	30	24	.	.	PUNCT
bptjm-57	31	1	factors	factor	NOUN
bptjm-57	31	2	genomic	genomic	ADJ
bptjm-57	31	3	instability	instability	NOUN
bptjm-57	31	4	clonal	clonal	ADJ
bptjm-57	31	5	evolution	evolution	NOUN
bptjm-57	31	6	microenvironmental	microenvironmental	ADJ
bptjm-57	31	7	factors	factor	NOUN
bptjm-57	31	8	phenotypic	phenotypic	VERB
bptjm-57	31	9	plasticity	plasticity	NOUN
bptjm-57	31	10	de	de	PROPN
bptjm-57	31	11	�	�	NOUN
bptjm-57	31	12	nition	nition	NOUN
bptjm-57	31	13	the	the	DET
bptjm-57	31	14	higher	high	ADJ
bptjm-57	31	15	tendency	tendency	NOUN
bptjm-57	31	16	of	of	ADP
bptjm-57	31	17	cells	cell	NOUN
bptjm-57	31	18	to	to	PART
bptjm-57	31	19	obtain	obtain	VERB
bptjm-57	31	20	genetic	genetic	ADJ
bptjm-57	31	21	alterations9	alterations9	NOUN
bptjm-57	31	22	the	the	DET
bptjm-57	31	23	process	process	NOUN
bptjm-57	31	24	by	by	ADP
bptjm-57	31	25	which	which	PRON
bptjm-57	31	26	di	di	PROPN
bptjm-57	31	27	�	�	PROPN
bptjm-57	31	28	erent	erent	NOUN
bptjm-57	31	29	subclones	subclone	NOUN
bptjm-57	31	30	within	within	ADP
bptjm-57	31	31	a	a	DET
bptjm-57	31	32	tumor	tumor	NOUN
bptjm-57	31	33	change	change	NOUN
bptjm-57	31	34	over	over	ADP
bptjm-57	31	35	time11	time11	ADJ
bptjm-57	31	36	factors	factor	NOUN
bptjm-57	31	37	(	(	PUNCT
bptjm-57	31	38	e.g.	e.g.	ADV
bptjm-57	31	39	oxygen	oxygen	NOUN
bptjm-57	31	40	,	,	PUNCT
bptjm-57	31	41	nutrient	nutrient	NOUN
bptjm-57	31	42	availability	availability	NOUN
bptjm-57	31	43	,	,	PUNCT
bptjm-57	31	44	immune	immune	ADJ
bptjm-57	31	45	cell	cell	NOUN
bptjm-57	31	46	in	in	ADP
bptjm-57	31	47	�	�	PROPN
bptjm-57	31	48	ltration	ltration	NOUN
bptjm-57	31	49	)	)	PUNCT
bptjm-57	31	50	and	and	CCONJ
bptjm-57	31	51	interactions	interaction	NOUN
bptjm-57	31	52	with	with	ADP
bptjm-57	31	53	surrounding	surround	VERB
bptjm-57	31	54	stromal	stromal	ADJ
bptjm-57	31	55	cells	cell	NOUN
bptjm-57	31	56	in	in	ADP
bptjm-57	31	57	the	the	DET
bptjm-57	31	58	tumor	tumor	NOUN
bptjm-57	31	59	microenvironment	microenvironment	NOUN
bptjm-57	31	60	the	the	DET
bptjm-57	31	61	ability	ability	NOUN
bptjm-57	31	62	of	of	ADP
bptjm-57	31	63	one	one	NUM
bptjm-57	31	64	genotype	genotype	NOUN
bptjm-57	31	65	to	to	PART
bptjm-57	31	66	cause	cause	VERB
bptjm-57	31	67	di	di	NOUN
bptjm-57	31	68	�	�	PROPN
bptjm-57	31	69	erent	erent	NOUN
bptjm-57	31	70	phenotypes	phenotype	NOUN
bptjm-57	31	71	to	to	PART
bptjm-57	31	72	arise	arise	VERB
bptjm-57	31	73	in	in	ADP
bptjm-57	31	74	response	response	NOUN
bptjm-57	31	75	to	to	ADP
bptjm-57	31	76	di	di	NOUN
bptjm-57	31	77	�	�	PROPN
bptjm-57	31	78	erent	erent	NOUN
bptjm-57	31	79	environments15	environments15	NOUN
bptjm-57	31	80	causes	cause	VERB
bptjm-57	31	81	anything	anything	PRON
bptjm-57	31	82	that	that	PRON
bptjm-57	31	83	causes	cause	VERB
bptjm-57	31	84	more	more	ADJ
bptjm-57	31	85	genetic	genetic	ADJ
bptjm-57	31	86	mutations	mutation	NOUN
bptjm-57	31	87	(	(	PUNCT
bptjm-57	31	88	e.g.	e.g.	ADV
bptjm-57	31	89	limitless	limitless	ADJ
bptjm-57	31	90	replicative	replicative	ADJ
bptjm-57	31	91	potential10	potential10	NOUN
bptjm-57	31	92	,	,	PUNCT
bptjm-57	31	93	dna	dna	PROPN
bptjm-57	31	94	repair	repair	VERB
bptjm-57	31	95	defects9	defects9	NOUN
bptjm-57	31	96	)	)	PUNCT
bptjm-57	31	97	typical	typical	ADJ
bptjm-57	31	98	evolutionary	evolutionary	ADJ
bptjm-57	31	99	processes12	processes12	NOUN
bptjm-57	31	100	in	in	ADP
bptjm-57	31	101	�	�	PROPN
bptjm-57	31	102	uenced	uence	VERB
bptjm-57	31	103	by	by	ADP
bptjm-57	31	104	many	many	ADJ
bptjm-57	31	105	factors	factor	NOUN
bptjm-57	31	106	,	,	PUNCT
bptjm-57	31	107	such	such	ADJ
bptjm-57	31	108	as	as	ADP
bptjm-57	31	109	the	the	DET
bptjm-57	31	110	tumor	tumor	NOUN
bptjm-57	31	111	microenvironment	microenvironment	NOUN
bptjm-57	31	112	,	,	PUNCT
bptjm-57	31	113	metabolism	metabolism	NOUN
bptjm-57	31	114	,	,	PUNCT
bptjm-57	31	115	growth	growth	NOUN
bptjm-57	31	116	factors	factor	NOUN
bptjm-57	31	117	,	,	PUNCT
bptjm-57	31	118	and	and	CCONJ
bptjm-57	31	119	mutation	mutation	NOUN
bptjm-57	31	120	collection	collection	NOUN
bptjm-57	31	121	of	of	ADP
bptjm-57	31	122	tumor	tumor	NOUN
bptjm-57	31	123	cells	cell	NOUN
bptjm-57	31	124	that	that	PRON
bptjm-57	31	125	combine	combine	VERB
bptjm-57	31	126	to	to	PART
bptjm-57	31	127	create	create	VERB
bptjm-57	31	128	the	the	DET
bptjm-57	31	129	tumor	tumor	NOUN
bptjm-57	31	130	microenvironment13	microenvironment13	NOUN
bptjm-57	31	131	consists	consist	VERB
bptjm-57	31	132	of	of	ADP
bptjm-57	31	133	the	the	DET
bptjm-57	31	134	extracellular	extracellular	ADJ
bptjm-57	31	135	matrix	matrix	NOUN
bptjm-57	31	136	,	,	PUNCT
bptjm-57	31	137	immune	immune	ADJ
bptjm-57	31	138	cells	cell	NOUN
bptjm-57	31	139	,	,	PUNCT
bptjm-57	31	140	and	and	CCONJ
bptjm-57	31	141	stromal	stromal	ADJ
bptjm-57	31	142	cells13	cells13	NOUN
bptjm-57	31	143	epithelial	epithelial	ADJ
bptjm-57	31	144	-	-	PUNCT
bptjm-57	31	145	tomesenchymal	tomesenchymal	ADJ
bptjm-57	31	146	transition	transition	NOUN
bptjm-57	31	147	(	(	PUNCT
bptjm-57	31	148	emt	emt	PROPN
bptjm-57	31	149	)	)	PUNCT
bptjm-57	31	150	and	and	CCONJ
bptjm-57	31	151	certain	certain	ADJ
bptjm-57	31	152	transcription	transcription	NOUN
bptjm-57	31	153	factors	factor	NOUN
bptjm-57	31	154	inducing	induce	VERB
bptjm-57	31	155	emt	emt	PROPN
bptjm-57	31	156	(	(	PUNCT
bptjm-57	31	157	e.g.	e.g.	ADV
bptjm-57	31	158	zeb1	zeb1	PROPN
bptjm-57	31	159	,	,	PUNCT
bptjm-57	31	160	twist)15	twist)15	PROPN
bptjm-57	31	161	genetic	genetic	ADJ
bptjm-57	31	162	mutations	mutation	NOUN
bptjm-57	31	163	and	and	CCONJ
bptjm-57	31	164	epigenetic	epigenetic	ADJ
bptjm-57	31	165	berkeley	berkeley	PROPN
bptjm-57	31	166	pharma	pharma	PROPN
bptjm-57	31	167	tech	tech	NOUN
bptjm-57	31	168	journal	journal	NOUN
bptjm-57	31	169	of	of	ADP
bptjm-57	31	170	medicine	medicine	NOUN
bptjm-57	32	1	|	|	ADV
bptjm-57	32	2	86	86	NUM
bptjm-57	32	3	rate12	rate12	NOUN
bptjm-57	32	4	modi	modi	PROPN
bptjm-57	32	5	�	�	PROPN
bptjm-57	32	6	cations	cation	NOUN
bptjm-57	32	7	e	e	NOUN
bptjm-57	32	8	�	�	NOUN
bptjm-57	32	9	ects	ect	VERB
bptjm-57	32	10	results	result	NOUN
bptjm-57	32	11	in	in	ADP
bptjm-57	32	12	genetically	genetically	ADV
bptjm-57	32	13	distinct	distinct	ADJ
bptjm-57	32	14	subpopulatio	subpopulatio	NOUN
bptjm-57	32	15	ns	ns	NUM
bptjm-57	32	16	of	of	ADP
bptjm-57	32	17	di	di	PROPN
bptjm-57	32	18	�	�	PROPN
bptjm-57	32	19	erent	erent	NOUN
bptjm-57	32	20	cells	cell	NOUN
bptjm-57	32	21	→	→	ADP
bptjm-57	32	22	genetic	genetic	ADJ
bptjm-57	32	23	heterogeneity	heterogeneity	NOUN
bptjm-57	32	24	leads	lead	VERB
bptjm-57	32	25	to	to	ADP
bptjm-57	32	26	the	the	DET
bptjm-57	32	27	expansion	expansion	NOUN
bptjm-57	32	28	of	of	ADP
bptjm-57	32	29	speci	speci	PROPN
bptjm-57	32	30	�	�	PROPN
bptjm-57	32	31	c	c	NOUN
bptjm-57	32	32	populations	population	NOUN
bptjm-57	32	33	of	of	ADP
bptjm-57	32	34	tumor	tumor	NOUN
bptjm-57	32	35	cells11→	cells11→	NOUN
bptjm-57	32	36	cellular	cellular	ADJ
bptjm-57	32	37	heterogeneity	heterogeneity	NOUN
bptjm-57	32	38	promotes	promote	VERB
bptjm-57	32	39	angiogenesis	angiogenesis	NOUN
bptjm-57	32	40	and	and	CCONJ
bptjm-57	32	41	an	an	DET
bptjm-57	32	42	environment	environment	NOUN
bptjm-57	32	43	for	for	ADP
bptjm-57	32	44	cancer	cancer	NOUN
bptjm-57	32	45	cells	cell	NOUN
bptjm-57	32	46	to	to	ADP
bptjm-57	32	47	grow14	grow14	PROPN
bptjm-57	32	48	prevents	prevent	VERB
bptjm-57	32	49	immune	immune	ADJ
bptjm-57	32	50	cells	cell	NOUN
bptjm-57	32	51	from	from	ADP
bptjm-57	32	52	in	in	ADP
bptjm-57	32	53	�	�	PROPN
bptjm-57	32	54	ltrating	ltrate	VERB
bptjm-57	32	55	the	the	DET
bptjm-57	32	56	tumor14	tumor14	NOUN
bptjm-57	32	57	in	in	ADP
bptjm-57	32	58	�	�	NOUN
bptjm-57	32	59	uences	uence	NOUN
bptjm-57	32	60	surrounding	surround	VERB
bptjm-57	32	61	cells	cell	NOUN
bptjm-57	32	62	and	and	CCONJ
bptjm-57	32	63	cancerous	cancerous	ADJ
bptjm-57	32	64	cells14	cells14	NOUN
bptjm-57	32	65	protects	protect	VERB
bptjm-57	32	66	metastasized	metastasize	VERB
bptjm-57	32	67	cancer	cancer	NOUN
bptjm-57	32	68	cells	cell	NOUN
bptjm-57	32	69	from	from	ADP
bptjm-57	32	70	ferroptosis	ferroptosis	NOUN
bptjm-57	32	71	,	,	PUNCT
bptjm-57	32	72	a	a	DET
bptjm-57	32	73	type	type	NOUN
bptjm-57	32	74	of	of	ADP
bptjm-57	32	75	cell	cell	NOUN
bptjm-57	32	76	death16	death16	NOUN
bptjm-57	32	77	give	give	VERB
bptjm-57	32	78	rise	rise	NOUN
bptjm-57	32	79	to	to	ADP
bptjm-57	32	80	subpopulations	subpopulation	NOUN
bptjm-57	32	81	of	of	ADP
bptjm-57	32	82	tumor	tumor	NOUN
bptjm-57	32	83	cells	cell	NOUN
bptjm-57	32	84	with	with	ADP
bptjm-57	32	85	distinct	distinct	ADJ
bptjm-57	32	86	functional	functional	ADJ
bptjm-57	32	87	properties16→	properties16→	ADJ
bptjm-57	32	88	cellular	cellular	ADJ
bptjm-57	32	89	heterogeneity	heterogeneity	NOUN
bptjm-57	32	90	table	table	NOUN
bptjm-57	32	91	1	1	NUM
bptjm-57	32	92	.	.	PUNCT
bptjm-57	33	1	factors	factor	NOUN
bptjm-57	33	2	contributing	contribute	VERB
bptjm-57	33	3	to	to	ADP
bptjm-57	33	4	tumor	tumor	NOUN
bptjm-57	33	5	heterogeneity	heterogeneity	NOUN
bptjm-57	33	6	.	.	PUNCT
bptjm-57	34	1	this	this	DET
bptjm-57	34	2	table	table	NOUN
bptjm-57	34	3	summarizes	summarize	VERB
bptjm-57	34	4	the	the	DET
bptjm-57	34	5	de	de	PROPN
bptjm-57	34	6	�	�	PROPN
bptjm-57	34	7	nition	nition	NOUN
bptjm-57	34	8	,	,	PUNCT
bptjm-57	34	9	causes	cause	NOUN
bptjm-57	34	10	,	,	PUNCT
bptjm-57	34	11	and	and	CCONJ
bptjm-57	34	12	e	e	NOUN
bptjm-57	34	13	�	�	NOUN
bptjm-57	34	14	ects	ect	NOUN
bptjm-57	34	15	of	of	ADP
bptjm-57	34	16	the	the	DET
bptjm-57	34	17	di	di	PROPN
bptjm-57	34	18	�	�	PROPN
bptjm-57	34	19	erent	erent	NOUN
bptjm-57	34	20	factors	factor	NOUN
bptjm-57	34	21	that	that	PRON
bptjm-57	34	22	contribute	contribute	VERB
bptjm-57	34	23	to	to	ADP
bptjm-57	34	24	tumor	tumor	NOUN
bptjm-57	34	25	heterogeneity	heterogeneity	NOUN
bptjm-57	34	26	–	–	PUNCT
bptjm-57	34	27	from	from	ADP
bptjm-57	34	28	left	leave	VERB
bptjm-57	34	29	to	to	ADP
bptjm-57	34	30	right	right	NOUN
bptjm-57	34	31	:	:	PUNCT
bptjm-57	34	32	genomic	genomic	ADJ
bptjm-57	34	33	instability	instability	NOUN
bptjm-57	34	34	,	,	PUNCT
bptjm-57	34	35	clonal	clonal	ADJ
bptjm-57	34	36	evolution	evolution	NOUN
bptjm-57	34	37	,	,	PUNCT
bptjm-57	34	38	microenvironmental	microenvironmental	ADJ
bptjm-57	34	39	factors	factor	NOUN
bptjm-57	34	40	,	,	PUNCT
bptjm-57	34	41	and	and	CCONJ
bptjm-57	34	42	phenotypic	phenotypic	ADJ
bptjm-57	34	43	plasticity	plasticity	NOUN
bptjm-57	34	44	.	.	PUNCT
bptjm-57	35	1	there	there	PRON
bptjm-57	35	2	are	be	VERB
bptjm-57	35	3	four	four	NUM
bptjm-57	35	4	types	type	NOUN
bptjm-57	35	5	of	of	ADP
bptjm-57	35	6	tumor	tumor	NOUN
bptjm-57	35	7	heterogeneity	heterogeneity	NOUN
bptjm-57	35	8	:	:	PUNCT
bptjm-57	35	9	intratumor	intratumor	PROPN
bptjm-57	35	10	,	,	PUNCT
bptjm-57	35	11	intermetastatic	intermetastatic	ADJ
bptjm-57	35	12	,	,	PUNCT
bptjm-57	35	13	intrametastatic	intrametastatic	ADJ
bptjm-57	35	14	,	,	PUNCT
bptjm-57	35	15	and	and	CCONJ
bptjm-57	35	16	interpatient	interpatient	NOUN
bptjm-57	35	17	.	.	PUNCT
bptjm-57	36	1	all	all	DET
bptjm-57	36	2	four	four	NUM
bptjm-57	36	3	types	type	NOUN
bptjm-57	36	4	cause	cause	VERB
bptjm-57	36	5	unique	unique	ADJ
bptjm-57	36	6	complications	complication	NOUN
bptjm-57	36	7	in	in	ADP
bptjm-57	36	8	the	the	DET
bptjm-57	36	9	clinical	clinical	ADJ
bptjm-57	36	10	process	process	NOUN
bptjm-57	36	11	.	.	PUNCT
bptjm-57	37	1	this	this	DET
bptjm-57	37	2	review	review	NOUN
bptjm-57	37	3	focuses	focus	VERB
bptjm-57	37	4	on	on	ADP
bptjm-57	37	5	intratumoral	intratumoral	ADJ
bptjm-57	37	6	heterogeneity	heterogeneity	NOUN
bptjm-57	37	7	,	,	PUNCT
bptjm-57	37	8	which	which	PRON
bptjm-57	37	9	refers	refer	VERB
bptjm-57	37	10	to	to	ADP
bptjm-57	37	11	phenotypic	phenotypic	ADJ
bptjm-57	37	12	or	or	CCONJ
bptjm-57	37	13	genetic	genetic	ADJ
bptjm-57	37	14	variation	variation	NOUN
bptjm-57	37	15	in	in	ADP
bptjm-57	37	16	cells	cell	NOUN
bptjm-57	37	17	within	within	ADP
bptjm-57	37	18	a	a	DET
bptjm-57	37	19	single	single	ADJ
bptjm-57	37	20	tumor	tumor	NOUN
bptjm-57	37	21	.	.	PUNCT
bptjm-57	38	1	the	the	DET
bptjm-57	38	2	other	other	ADJ
bptjm-57	38	3	three	three	NUM
bptjm-57	38	4	types	type	NOUN
bptjm-57	38	5	of	of	ADP
bptjm-57	38	6	tumor	tumor	NOUN
bptjm-57	38	7	heterogeneity	heterogeneity	PROPN
bptjm-57	38	8	o	o	NOUN
bptjm-57	38	9	�	�	NOUN
bptjm-57	38	10	er	er	ADJ
bptjm-57	38	11	additional	additional	ADJ
bptjm-57	38	12	context	context	NOUN
bptjm-57	38	13	to	to	ADP
bptjm-57	38	14	the	the	DET
bptjm-57	38	15	complexities	complexity	NOUN
bptjm-57	38	16	of	of	ADP
bptjm-57	38	17	tumor	tumor	NOUN
bptjm-57	38	18	heterogeneity	heterogeneity	NOUN
bptjm-57	38	19	.	.	PUNCT
bptjm-57	39	1	for	for	ADP
bptjm-57	39	2	instance	instance	NOUN
bptjm-57	39	3	,	,	PUNCT
bptjm-57	39	4	intermetastatic	intermetastatic	ADJ
bptjm-57	39	5	heterogeneity	heterogeneity	NOUN
bptjm-57	39	6	is	be	AUX
bptjm-57	39	7	the	the	DET
bptjm-57	39	8	variety	variety	NOUN
bptjm-57	39	9	between	between	ADP
bptjm-57	39	10	two	two	NUM
bptjm-57	39	11	metastatic	metastatic	ADJ
bptjm-57	39	12	tumors	tumor	NOUN
bptjm-57	39	13	within	within	ADP
bptjm-57	39	14	the	the	DET
bptjm-57	39	15	same	same	ADJ
bptjm-57	39	16	patient	patient	NOUN
bptjm-57	39	17	;	;	PUNCT
bptjm-57	39	18	metastatic	metastatic	ADJ
bptjm-57	39	19	tumors	tumor	NOUN
bptjm-57	39	20	are	be	AUX
bptjm-57	39	21	two	two	NUM
bptjm-57	39	22	or	or	CCONJ
bptjm-57	39	23	more	more	ADJ
bptjm-57	39	24	tumors	tumor	NOUN
bptjm-57	39	25	that	that	PRON
bptjm-57	39	26	di	di	PROPN
bptjm-57	39	27	�	�	PROPN
bptjm-57	39	28	er	er	NUM
bptjm-57	39	29	from	from	ADP
bptjm-57	39	30	one	one	NUM
bptjm-57	39	31	another	another	DET
bptjm-57	39	32	.	.	PUNCT
bptjm-57	40	1	intrametastatic	intrametastatic	ADJ
bptjm-57	40	2	heterogeneity	heterogeneity	NOUN
bptjm-57	40	3	is	be	AUX
bptjm-57	40	4	ith	ith	NOUN
bptjm-57	40	5	within	within	ADP
bptjm-57	40	6	a	a	DET
bptjm-57	40	7	metastasis	metastasis	NOUN
bptjm-57	40	8	–	–	PUNCT
bptjm-57	40	9	there	there	PRON
bptjm-57	40	10	is	be	VERB
bptjm-57	40	11	variation	variation	NOUN
bptjm-57	40	12	within	within	ADP
bptjm-57	40	13	that	that	DET
bptjm-57	40	14	single	single	ADJ
bptjm-57	40	15	lesion	lesion	NOUN
bptjm-57	40	16	.	.	PUNCT
bptjm-57	41	1	lastly	lastly	ADV
bptjm-57	41	2	,	,	PUNCT
bptjm-57	41	3	interpatient	interpatient	ADJ
bptjm-57	41	4	heterogeneity	heterogeneity	NOUN
bptjm-57	41	5	is	be	AUX
bptjm-57	41	6	the	the	DET
bptjm-57	41	7	di	di	NOUN
bptjm-57	41	8	�	�	PROPN
bptjm-57	41	9	erence	erence	NOUN
bptjm-57	41	10	in	in	ADP
bptjm-57	41	11	tumors	tumor	NOUN
bptjm-57	41	12	between	between	ADP
bptjm-57	41	13	di	di	NOUN
bptjm-57	41	14	�	�	PROPN
bptjm-57	41	15	erent	erent	NOUN
bptjm-57	41	16	patients	patient	NOUN
bptjm-57	41	17	possessing	possess	VERB
bptjm-57	41	18	the	the	DET
bptjm-57	41	19	same	same	ADJ
bptjm-57	41	20	type	type	NOUN
bptjm-57	41	21	of	of	ADP
bptjm-57	41	22	cancer	cancer	NOUN
bptjm-57	41	23	.	.	PUNCT
bptjm-57	42	1	interpatient	interpatient	PROPN
bptjm-57	42	2	heterogeneity	heterogeneity	NOUN
bptjm-57	42	3	is	be	AUX
bptjm-57	42	4	the	the	DET
bptjm-57	42	5	main	main	ADJ
bptjm-57	42	6	reason	reason	NOUN
bptjm-57	42	7	for	for	ADP
bptjm-57	42	8	the	the	DET
bptjm-57	42	9	need	need	NOUN
bptjm-57	42	10	of	of	ADP
bptjm-57	42	11	personalized	personalized	ADJ
bptjm-57	42	12	treatments	treatment	NOUN
bptjm-57	42	13	,	,	PUNCT
bptjm-57	42	14	regardless	regardless	ADV
bptjm-57	42	15	of	of	ADP
bptjm-57	42	16	the	the	DET
bptjm-57	42	17	level	level	NOUN
bptjm-57	42	18	of	of	ADP
bptjm-57	42	19	variation	variation	NOUN
bptjm-57	42	20	observed	observe	VERB
bptjm-57	42	21	within	within	ADP
bptjm-57	42	22	a	a	DET
bptjm-57	42	23	single	single	ADJ
bptjm-57	42	24	tumor.17	tumor.17	NOUN
bptjm-57	42	25	berkeley	berkeley	PROPN
bptjm-57	42	26	pharma	pharma	PROPN
bptjm-57	42	27	tech	tech	NOUN
bptjm-57	42	28	journal	journal	NOUN
bptjm-57	42	29	of	of	ADP
bptjm-57	42	30	medicine	medicine	NOUN
bptjm-57	42	31	|	|	ADV
bptjm-57	42	32	87	87	NUM
bptjm-57	42	33	figure	figure	NOUN
bptjm-57	42	34	1	1	NUM
bptjm-57	42	35	.	.	NUM
bptjm-57	42	36	types	type	NOUN
bptjm-57	42	37	of	of	ADP
bptjm-57	42	38	tumor	tumor	NOUN
bptjm-57	42	39	heterogeneity	heterogeneity	NOUN
bptjm-57	42	40	.	.	PUNCT
bptjm-57	43	1	the	the	DET
bptjm-57	43	2	di	di	PROPN
bptjm-57	43	3	�	�	PROPN
bptjm-57	43	4	erent	erent	NOUN
bptjm-57	43	5	-	-	PUNCT
bptjm-57	43	6	colored	color	VERB
bptjm-57	43	7	dots	dot	NOUN
bptjm-57	43	8	represent	represent	VERB
bptjm-57	43	9	di	di	PROPN
bptjm-57	43	10	�	�	PROPN
bptjm-57	43	11	erent	erent	NOUN
bptjm-57	43	12	subpopulations	subpopulation	NOUN
bptjm-57	43	13	of	of	ADP
bptjm-57	43	14	cells	cell	NOUN
bptjm-57	43	15	in	in	ADP
bptjm-57	43	16	a	a	DET
bptjm-57	43	17	tumor	tumor	NOUN
bptjm-57	43	18	–	–	PUNCT
bptjm-57	43	19	in	in	ADP
bptjm-57	43	20	other	other	ADJ
bptjm-57	43	21	words	word	NOUN
bptjm-57	43	22	,	,	PUNCT
bptjm-57	43	23	tumor	tumor	NOUN
bptjm-57	43	24	heterogeneity	heterogeneity	NOUN
bptjm-57	43	25	.	.	PUNCT
bptjm-57	44	1	the	the	DET
bptjm-57	44	2	top	top	ADJ
bptjm-57	44	3	left	left	ADJ
bptjm-57	44	4	circle	circle	NOUN
bptjm-57	44	5	represents	represent	VERB
bptjm-57	44	6	interpatient	interpatient	ADJ
bptjm-57	44	7	tumor	tumor	NOUN
bptjm-57	44	8	heterogeneity	heterogeneity	NOUN
bptjm-57	44	9	between	between	ADP
bptjm-57	44	10	two	two	NUM
bptjm-57	44	11	patients	patient	NOUN
bptjm-57	44	12	with	with	ADP
bptjm-57	44	13	tumors	tumor	NOUN
bptjm-57	44	14	in	in	ADP
bptjm-57	44	15	their	their	PRON
bptjm-57	44	16	liver	liver	NOUN
bptjm-57	44	17	,	,	PUNCT
bptjm-57	44	18	where	where	SCONJ
bptjm-57	44	19	despite	despite	SCONJ
bptjm-57	44	20	having	have	VERB
bptjm-57	44	21	the	the	DET
bptjm-57	44	22	same	same	ADJ
bptjm-57	44	23	cancer	cancer	NOUN
bptjm-57	44	24	,	,	PUNCT
bptjm-57	44	25	their	their	PRON
bptjm-57	44	26	tumors	tumor	NOUN
bptjm-57	44	27	have	have	VERB
bptjm-57	44	28	unique	unique	ADJ
bptjm-57	44	29	subpopulations	subpopulation	NOUN
bptjm-57	44	30	of	of	ADP
bptjm-57	44	31	cancer	cancer	NOUN
bptjm-57	44	32	cells	cell	NOUN
bptjm-57	44	33	.	.	PUNCT
bptjm-57	45	1	the	the	DET
bptjm-57	45	2	top	top	ADJ
bptjm-57	45	3	right	right	ADJ
bptjm-57	45	4	circle	circle	NOUN
bptjm-57	45	5	shows	show	VERB
bptjm-57	45	6	intermetastatic	intermetastatic	ADJ
bptjm-57	45	7	heterogeneity	heterogeneity	NOUN
bptjm-57	45	8	in	in	ADP
bptjm-57	45	9	a	a	DET
bptjm-57	45	10	single	single	ADJ
bptjm-57	45	11	patient	patient	NOUN
bptjm-57	45	12	.	.	PUNCT
bptjm-57	46	1	the	the	DET
bptjm-57	46	2	diagram	diagram	NOUN
bptjm-57	46	3	illustrates	illustrate	VERB
bptjm-57	46	4	how	how	SCONJ
bptjm-57	46	5	di	di	X
bptjm-57	46	6	�	�	PROPN
bptjm-57	46	7	erent	erent	NOUN
bptjm-57	46	8	subpopulations	subpopulation	NOUN
bptjm-57	46	9	of	of	ADP
bptjm-57	46	10	cancer	cancer	NOUN
bptjm-57	46	11	cells	cell	NOUN
bptjm-57	46	12	from	from	ADP
bptjm-57	46	13	the	the	DET
bptjm-57	46	14	liver	liver	NOUN
bptjm-57	46	15	metastasize	metastasize	NOUN
bptjm-57	46	16	to	to	ADP
bptjm-57	46	17	the	the	DET
bptjm-57	46	18	lung	lung	NOUN
bptjm-57	46	19	and	and	CCONJ
bptjm-57	46	20	the	the	DET
bptjm-57	46	21	brain	brain	NOUN
bptjm-57	46	22	,	,	PUNCT
bptjm-57	46	23	resulting	result	VERB
bptjm-57	46	24	in	in	ADP
bptjm-57	46	25	the	the	DET
bptjm-57	46	26	presence	presence	NOUN
bptjm-57	46	27	of	of	ADP
bptjm-57	46	28	tumor	tumor	NOUN
bptjm-57	46	29	heterogeneity	heterogeneity	NOUN
bptjm-57	46	30	between	between	ADP
bptjm-57	46	31	the	the	DET
bptjm-57	46	32	di	di	PROPN
bptjm-57	46	33	�	�	PROPN
bptjm-57	46	34	erent	erent	NOUN
bptjm-57	46	35	metastatic	metastatic	ADJ
bptjm-57	46	36	lesions	lesion	NOUN
bptjm-57	46	37	.	.	PUNCT
bptjm-57	47	1	the	the	DET
bptjm-57	47	2	bottom	bottom	NOUN
bptjm-57	47	3	left	leave	VERB
bptjm-57	47	4	circle	circle	NOUN
bptjm-57	47	5	displays	display	VERB
bptjm-57	47	6	intrametastatic	intrametastatic	ADJ
bptjm-57	47	7	heterogeneity	heterogeneity	NOUN
bptjm-57	47	8	,	,	PUNCT
bptjm-57	47	9	where	where	SCONJ
bptjm-57	47	10	di	di	X
bptjm-57	47	11	�	�	PROPN
bptjm-57	47	12	erent	erent	NOUN
bptjm-57	47	13	subpopulations	subpopulation	NOUN
bptjm-57	47	14	of	of	ADP
bptjm-57	47	15	cancer	cancer	NOUN
bptjm-57	47	16	cells	cell	NOUN
bptjm-57	47	17	are	be	AUX
bptjm-57	47	18	present	present	ADJ
bptjm-57	47	19	within	within	ADP
bptjm-57	47	20	a	a	DET
bptjm-57	47	21	lung	lung	NOUN
bptjm-57	47	22	metastasis	metastasis	NOUN
bptjm-57	47	23	.	.	PUNCT
bptjm-57	48	1	lastly	lastly	ADV
bptjm-57	48	2	,	,	PUNCT
bptjm-57	48	3	the	the	DET
bptjm-57	48	4	bottom	bottom	ADJ
bptjm-57	48	5	right	right	PROPN
bptjm-57	48	6	circle	circle	PROPN
bptjm-57	48	7	shows	show	VERB
bptjm-57	48	8	intratumor	intratumor	PROPN
bptjm-57	48	9	heterogeneity	heterogeneity	NOUN
bptjm-57	48	10	in	in	ADP
bptjm-57	48	11	the	the	DET
bptjm-57	48	12	liver	liver	NOUN
bptjm-57	48	13	of	of	ADP
bptjm-57	48	14	a	a	DET
bptjm-57	48	15	single	single	ADJ
bptjm-57	48	16	patient	patient	NOUN
bptjm-57	48	17	,	,	PUNCT
bptjm-57	48	18	where	where	SCONJ
bptjm-57	48	19	the	the	DET
bptjm-57	48	20	primary	primary	ADJ
bptjm-57	48	21	tumor	tumor	NOUN
bptjm-57	48	22	contains	contain	VERB
bptjm-57	48	23	di	di	NOUN
bptjm-57	48	24	�	�	PROPN
bptjm-57	48	25	erent	erent	NOUN
bptjm-57	48	26	subpopulations	subpopulation	NOUN
bptjm-57	48	27	of	of	ADP
bptjm-57	48	28	cancer	cancer	NOUN
bptjm-57	48	29	cells	cell	NOUN
bptjm-57	48	30	.	.	PUNCT
bptjm-57	49	1	2.2	2.2	NUM
bptjm-57	49	2	intratumoral	intratumoral	ADJ
bptjm-57	49	3	heterogeneity	heterogeneity	NOUN
bptjm-57	49	4	across	across	ADP
bptjm-57	49	5	di	di	NOUN
bptjm-57	49	6	�	�	PROPN
bptjm-57	49	7	erent	erent	NOUN
bptjm-57	49	8	types	type	NOUN
bptjm-57	49	9	of	of	ADP
bptjm-57	49	10	cancers	cancer	NOUN
bptjm-57	49	11	intratumoral	intratumoral	ADJ
bptjm-57	49	12	heterogeneity	heterogeneity	NOUN
bptjm-57	49	13	can	can	AUX
bptjm-57	49	14	re	re	AUX
bptjm-57	49	15	�	�	VERB
bptjm-57	49	16	ect	ect	VERB
bptjm-57	49	17	genetic	genetic	ADJ
bptjm-57	49	18	alterations	alteration	NOUN
bptjm-57	49	19	in	in	ADP
bptjm-57	49	20	the	the	DET
bptjm-57	49	21	tumor	tumor	NOUN
bptjm-57	49	22	,	,	PUNCT
bptjm-57	49	23	which	which	PRON
bptjm-57	49	24	can	can	AUX
bptjm-57	49	25	a	a	DET
bptjm-57	49	26	�	�	NOUN
bptjm-57	49	27	ect	ect	ADJ
bptjm-57	49	28	disease	disease	NOUN
bptjm-57	49	29	progression	progression	NOUN
bptjm-57	49	30	and	and	CCONJ
bptjm-57	49	31	treatment	treatment	NOUN
bptjm-57	49	32	response	response	NOUN
bptjm-57	49	33	.	.	PUNCT
bptjm-57	50	1	for	for	ADP
bptjm-57	50	2	example	example	NOUN
bptjm-57	50	3	,	,	PUNCT
bptjm-57	50	4	mutations	mutation	NOUN
bptjm-57	50	5	in	in	ADP
bptjm-57	50	6	genes	gene	NOUN
bptjm-57	50	7	like	like	ADP
bptjm-57	50	8	brca1	brca1	PROPN
bptjm-57	50	9	,	,	PUNCT
bptjm-57	50	10	brca2	brca2	PROPN
bptjm-57	50	11	,	,	PUNCT
bptjm-57	50	12	tp53	tp53	PROPN
bptjm-57	50	13	,	,	PUNCT
bptjm-57	50	14	and	and	CCONJ
bptjm-57	50	15	her2	her2	VERB
bptjm-57	50	16	in	in	ADP
bptjm-57	50	17	breast	breast	NOUN
bptjm-57	50	18	cancer	cancer	NOUN
bptjm-57	50	19	were	be	AUX
bptjm-57	50	20	identi	identi	X
bptjm-57	50	21	�	�	NOUN
bptjm-57	50	22	ed	ed	NOUN
bptjm-57	50	23	as	as	ADP
bptjm-57	50	24	risk	risk	NOUN
bptjm-57	50	25	factors	factor	NOUN
bptjm-57	50	26	in	in	ADP
bptjm-57	50	27	cancer	cancer	NOUN
bptjm-57	50	28	development	development	NOUN
bptjm-57	50	29	and	and	CCONJ
bptjm-57	50	30	can	can	AUX
bptjm-57	50	31	impact	impact	VERB
bptjm-57	50	32	treatment	treatment	NOUN
bptjm-57	50	33	outcomes.18additionally	outcomes.18additionally	ADV
bptjm-57	50	34	,	,	PUNCT
bptjm-57	50	35	in	in	ADP
bptjm-57	50	36	lung	lung	NOUN
bptjm-57	50	37	cancer	cancer	NOUN
bptjm-57	50	38	,	,	PUNCT
bptjm-57	50	39	mutations	mutation	NOUN
bptjm-57	50	40	in	in	ADP
bptjm-57	50	41	epidermal	epidermal	ADJ
bptjm-57	50	42	growth	growth	NOUN
bptjm-57	50	43	factor	factor	NOUN
bptjm-57	50	44	receptor	receptor	NOUN
bptjm-57	50	45	(	(	PUNCT
bptjm-57	50	46	egfr	egfr	X
bptjm-57	50	47	)	)	PUNCT
bptjm-57	50	48	and	and	CCONJ
bptjm-57	50	49	kras	kras	PROPN
bptjm-57	50	50	,	,	PUNCT
bptjm-57	50	51	along	along	ADP
bptjm-57	50	52	with	with	ADP
bptjm-57	50	53	alk	alk	NOUN
bptjm-57	50	54	and	and	CCONJ
bptjm-57	50	55	ros1	ros1	PROPN
bptjm-57	50	56	berkeley	berkeley	PROPN
bptjm-57	50	57	pharma	pharma	PROPN
bptjm-57	50	58	tech	tech	NOUN
bptjm-57	50	59	journal	journal	NOUN
bptjm-57	50	60	of	of	ADP
bptjm-57	50	61	medicine	medicine	NOUN
bptjm-57	50	62	|	|	ADV
bptjm-57	50	63	88	88	NUM
bptjm-57	50	64	rearrangements	rearrangement	NOUN
bptjm-57	50	65	,	,	PUNCT
bptjm-57	50	66	are	be	AUX
bptjm-57	50	67	signi	signi	ADJ
bptjm-57	50	68	�	�	NOUN
bptjm-57	50	69	cant	cant	VERB
bptjm-57	50	70	determinants	determinant	NOUN
bptjm-57	50	71	of	of	ADP
bptjm-57	50	72	tumor	tumor	NOUN
bptjm-57	50	73	behavior	behavior	NOUN
bptjm-57	50	74	and	and	CCONJ
bptjm-57	50	75	therapeutic	therapeutic	ADJ
bptjm-57	50	76	choices.19,20	choices.19,20	NOUN
bptjm-57	50	77	identifying	identify	VERB
bptjm-57	50	78	these	these	DET
bptjm-57	50	79	genetic	genetic	ADJ
bptjm-57	50	80	variations	variation	NOUN
bptjm-57	50	81	allows	allow	VERB
bptjm-57	50	82	physicians	physician	NOUN
bptjm-57	50	83	to	to	PART
bptjm-57	50	84	accommodate	accommodate	VERB
bptjm-57	50	85	treatment	treatment	NOUN
bptjm-57	50	86	plans	plan	NOUN
bptjm-57	50	87	to	to	PART
bptjm-57	50	88	tumor	tumor	VERB
bptjm-57	50	89	-	-	PUNCT
bptjm-57	50	90	particular	particular	ADJ
bptjm-57	50	91	genetic	genetic	ADJ
bptjm-57	50	92	structures	structure	NOUN
bptjm-57	50	93	,	,	PUNCT
bptjm-57	50	94	resulting	result	VERB
bptjm-57	50	95	in	in	ADP
bptjm-57	50	96	more	more	ADJ
bptjm-57	50	97	e	e	NOUN
bptjm-57	50	98	�	�	NOUN
bptjm-57	50	99	ective	ective	ADJ
bptjm-57	50	100	treatments	treatment	NOUN
bptjm-57	50	101	and	and	CCONJ
bptjm-57	50	102	improved	improve	VERB
bptjm-57	50	103	patient	patient	ADJ
bptjm-57	50	104	outcomes	outcome	NOUN
bptjm-57	50	105	.	.	PUNCT
bptjm-57	51	1	one	one	NUM
bptjm-57	51	2	method	method	NOUN
bptjm-57	51	3	that	that	PRON
bptjm-57	51	4	targets	target	VERB
bptjm-57	51	5	these	these	DET
bptjm-57	51	6	genetic	genetic	ADJ
bptjm-57	51	7	mutations	mutation	NOUN
bptjm-57	51	8	is	be	AUX
bptjm-57	51	9	crispr	crispr	ADJ
bptjm-57	51	10	-	-	PUNCT
bptjm-57	51	11	cas9	cas9	NOUN
bptjm-57	51	12	-	-	PUNCT
bptjm-57	51	13	mediated	mediate	VERB
bptjm-57	51	14	genome	genome	NOUN
bptjm-57	51	15	editing	editing	NOUN
bptjm-57	51	16	,	,	PUNCT
bptjm-57	51	17	which	which	PRON
bptjm-57	51	18	can	can	AUX
bptjm-57	51	19	be	be	AUX
bptjm-57	51	20	utilized	utilize	VERB
bptjm-57	51	21	to	to	PART
bptjm-57	51	22	target	target	VERB
bptjm-57	51	23	speci	speci	PROPN
bptjm-57	51	24	�	�	PROPN
bptjm-57	51	25	c	c	NOUN
bptjm-57	51	26	alleles	allele	NOUN
bptjm-57	51	27	,	,	PUNCT
bptjm-57	51	28	such	such	ADJ
bptjm-57	51	29	as	as	ADP
bptjm-57	51	30	the	the	DET
bptjm-57	51	31	tp53	tp53	PROPN
bptjm-57	51	32	gene	gene	NOUN
bptjm-57	51	33	in	in	ADP
bptjm-57	51	34	khos	khos	NOUN
bptjm-57	51	35	and	and	CCONJ
bptjm-57	51	36	khosr2	khosr2	PROPN
bptjm-57	51	37	cell	cell	NOUN
bptjm-57	51	38	lines	line	NOUN
bptjm-57	51	39	of	of	ADP
bptjm-57	51	40	osteosarcoma	osteosarcoma	NOUN
bptjm-57	51	41	.	.	PUNCT
bptjm-57	52	1	this	this	DET
bptjm-57	52	2	technology	technology	NOUN
bptjm-57	52	3	can	can	AUX
bptjm-57	52	4	hinder	hinder	VERB
bptjm-57	52	5	tumor	tumor	NOUN
bptjm-57	52	6	proliferation	proliferation	NOUN
bptjm-57	52	7	and	and	CCONJ
bptjm-57	52	8	migration	migration	NOUN
bptjm-57	52	9	,	,	PUNCT
bptjm-57	52	10	as	as	ADV
bptjm-57	52	11	well	well	ADV
bptjm-57	52	12	as	as	ADP
bptjm-57	52	13	modify	modify	VERB
bptjm-57	52	14	drug	drug	NOUN
bptjm-57	52	15	sensitivity	sensitivity	NOUN
bptjm-57	52	16	in	in	ADP
bptjm-57	52	17	cancer	cancer	NOUN
bptjm-57	52	18	treatment.21	treatment.21	NOUN
bptjm-57	52	19	cellular	cellular	ADJ
bptjm-57	52	20	heterogeneity	heterogeneity	NOUN
bptjm-57	52	21	in	in	ADP
bptjm-57	52	22	ith	ith	PROPN
bptjm-57	52	23	refers	refer	VERB
bptjm-57	52	24	to	to	ADP
bptjm-57	52	25	the	the	DET
bptjm-57	52	26	numerous	numerous	ADJ
bptjm-57	52	27	subpopulations	subpopulation	NOUN
bptjm-57	52	28	of	of	ADP
bptjm-57	52	29	cells	cell	NOUN
bptjm-57	52	30	inside	inside	ADP
bptjm-57	52	31	a	a	DET
bptjm-57	52	32	tumor	tumor	NOUN
bptjm-57	52	33	,	,	PUNCT
bptjm-57	52	34	each	each	PRON
bptjm-57	52	35	with	with	ADP
bptjm-57	52	36	precise	precise	ADJ
bptjm-57	52	37	traits	trait	NOUN
bptjm-57	52	38	and	and	CCONJ
bptjm-57	52	39	sets	set	NOUN
bptjm-57	52	40	of	of	ADP
bptjm-57	52	41	behaviors	behavior	NOUN
bptjm-57	52	42	.	.	PUNCT
bptjm-57	53	1	for	for	ADP
bptjm-57	53	2	instance	instance	NOUN
bptjm-57	53	3	,	,	PUNCT
bptjm-57	53	4	cell	cell	NOUN
bptjm-57	53	5	types	type	NOUN
bptjm-57	53	6	in	in	ADP
bptjm-57	53	7	breast	breast	NOUN
bptjm-57	53	8	cancer	cancer	NOUN
bptjm-57	53	9	include	include	VERB
bptjm-57	53	10	luminal	luminal	ADJ
bptjm-57	53	11	cells	cell	NOUN
bptjm-57	53	12	,	,	PUNCT
bptjm-57	53	13	basal	basal	NOUN
bptjm-57	53	14	-	-	PUNCT
bptjm-57	53	15	like	like	ADJ
bptjm-57	53	16	cells	cell	NOUN
bptjm-57	53	17	,	,	PUNCT
bptjm-57	53	18	and	and	CCONJ
bptjm-57	53	19	her2	her2	PROPN
bptjm-57	53	20	-	-	PUNCT
bptjm-57	53	21	positive	positive	ADJ
bptjm-57	53	22	cells	cell	NOUN
bptjm-57	53	23	,	,	PUNCT
bptjm-57	53	24	all	all	PRON
bptjm-57	53	25	of	of	ADP
bptjm-57	53	26	which	which	PRON
bptjm-57	53	27	impact	impact	VERB
bptjm-57	53	28	general	general	ADJ
bptjm-57	53	29	tumor	tumor	NOUN
bptjm-57	53	30	behavior	behavior	NOUN
bptjm-57	53	31	due	due	ADP
bptjm-57	53	32	to	to	ADP
bptjm-57	53	33	di	di	NOUN
bptjm-57	53	34	�	�	NOUN
bptjm-57	53	35	erent	erent	NOUN
bptjm-57	53	36	signaling	signal	VERB
bptjm-57	53	37	pathways	pathway	NOUN
bptjm-57	53	38	and	and	CCONJ
bptjm-57	53	39	levels	level	NOUN
bptjm-57	53	40	of	of	ADP
bptjm-57	53	41	receptor	receptor	NOUN
bptjm-57	53	42	expression	expression	NOUN
bptjm-57	53	43	.	.	PUNCT
bptjm-57	54	1	22,23	22,23	ADJ
bptjm-57	54	2	understanding	understand	VERB
bptjm-57	54	3	cellular	cellular	ADJ
bptjm-57	54	4	heterogeneity	heterogeneity	NOUN
bptjm-57	54	5	helps	help	VERB
bptjm-57	54	6	researchers	researcher	NOUN
bptjm-57	54	7	and	and	CCONJ
bptjm-57	54	8	clinicians	clinician	NOUN
bptjm-57	54	9	identify	identify	VERB
bptjm-57	54	10	potential	potential	ADJ
bptjm-57	54	11	targets	target	NOUN
bptjm-57	54	12	for	for	ADP
bptjm-57	54	13	therapy	therapy	NOUN
bptjm-57	54	14	since	since	SCONJ
bptjm-57	54	15	di	di	NOUN
bptjm-57	54	16	�	�	PROPN
bptjm-57	54	17	erent	erent	NOUN
bptjm-57	54	18	cell	cell	NOUN
bptjm-57	54	19	populations	population	NOUN
bptjm-57	54	20	may	may	AUX
bptjm-57	54	21	respond	respond	VERB
bptjm-57	54	22	di	di	NOUN
bptjm-57	54	23	�	�	PROPN
bptjm-57	54	24	erently	erently	ADV
bptjm-57	54	25	to	to	ADP
bptjm-57	54	26	various	various	ADJ
bptjm-57	54	27	treatments	treatment	NOUN
bptjm-57	54	28	.	.	PUNCT
bptjm-57	55	1	targeting	target	VERB
bptjm-57	55	2	particular	particular	ADJ
bptjm-57	55	3	cellular	cellular	ADJ
bptjm-57	55	4	subpopulations	subpopulation	NOUN
bptjm-57	55	5	would	would	AUX
bptjm-57	55	6	disrupt	disrupt	VERB
bptjm-57	55	7	a	a	DET
bptjm-57	55	8	tumor	tumor	NOUN
bptjm-57	55	9	’s	’s	PART
bptjm-57	55	10	growth	growth	NOUN
bptjm-57	55	11	and	and	CCONJ
bptjm-57	55	12	development	development	NOUN
bptjm-57	55	13	more	more	ADJ
bptjm-57	55	14	e	e	NOUN
bptjm-57	55	15	�	�	NOUN
bptjm-57	55	16	ectively	ectively	ADJ
bptjm-57	55	17	.	.	PUNCT
bptjm-57	56	1	table	table	NOUN
bptjm-57	56	2	2	2	NUM
bptjm-57	56	3	provides	provide	VERB
bptjm-57	56	4	a	a	DET
bptjm-57	56	5	comprehensive	comprehensive	ADJ
bptjm-57	56	6	overview	overview	NOUN
bptjm-57	56	7	of	of	ADP
bptjm-57	56	8	the	the	DET
bptjm-57	56	9	genetic	genetic	ADJ
bptjm-57	56	10	and	and	CCONJ
bptjm-57	56	11	cellular	cellular	ADJ
bptjm-57	56	12	heterogeneity	heterogeneity	NOUN
bptjm-57	56	13	observed	observe	VERB
bptjm-57	56	14	in	in	ADP
bptjm-57	56	15	key	key	ADJ
bptjm-57	56	16	cancer	cancer	NOUN
bptjm-57	56	17	types	type	NOUN
bptjm-57	56	18	.	.	PUNCT
bptjm-57	57	1	cancer	cancer	NOUN
bptjm-57	57	2	type	type	NOUN
bptjm-57	57	3	genetic	genetic	ADJ
bptjm-57	57	4	heterogeneity	heterogeneity	NOUN
bptjm-57	57	5	cellular	cellular	ADJ
bptjm-57	57	6	heterogeneity	heterogeneity	NOUN
bptjm-57	57	7	breast	breast	NOUN
bptjm-57	57	8	cancer	cancer	PROPN
bptjm-57	57	9	brca1	brca1	PROPN
bptjm-57	57	10	,	,	PUNCT
bptjm-57	57	11	brca2	brca2	PROPN
bptjm-57	57	12	,	,	PUNCT
bptjm-57	57	13	tp53	tp53	PROPN
bptjm-57	57	14	,	,	PUNCT
bptjm-57	57	15	her2	her2	PROPN
bptjm-57	57	16	/	/	SYM
bptjm-57	57	17	neu	neu	PROPN
bptjm-57	57	18	mutations18	mutations18	ADJ
bptjm-57	57	19	luminal	luminal	ADJ
bptjm-57	57	20	cells	cell	NOUN
bptjm-57	57	21	,	,	PUNCT
bptjm-57	57	22	basal	basal	NOUN
bptjm-57	57	23	-	-	PUNCT
bptjm-57	57	24	like	like	ADJ
bptjm-57	57	25	cells	cell	NOUN
bptjm-57	57	26	,	,	PUNCT
bptjm-57	57	27	her2	her2	PROPN
bptjm-57	57	28	-	-	PUNCT
bptjm-57	57	29	positive	positive	ADJ
bptjm-57	57	30	cells22,23	cells22,23	NOUN
bptjm-57	57	31	lung	lung	NOUN
bptjm-57	57	32	cancer	cancer	NOUN
bptjm-57	57	33	egfrmutations	egfrmutation	NOUN
bptjm-57	57	34	,	,	PUNCT
bptjm-57	57	35	kras	kras	PROPN
bptjm-57	57	36	mutations	mutation	NOUN
bptjm-57	57	37	,	,	PUNCT
bptjm-57	57	38	alk	alk	VERB
bptjm-57	57	39	rearrangements	rearrangement	NOUN
bptjm-57	57	40	,	,	PUNCT
bptjm-57	57	41	ros1	ros1	PROPN
bptjm-57	57	42	rearrangements19,20	rearrangements19,20	NOUN
bptjm-57	57	43	adenocarcinoma	adenocarcinoma	NOUN
bptjm-57	57	44	cells	cell	NOUN
bptjm-57	57	45	,	,	PUNCT
bptjm-57	57	46	squamous	squamous	ADJ
bptjm-57	57	47	cell	cell	NOUN
bptjm-57	57	48	carcinoma	carcinoma	NOUN
bptjm-57	57	49	cells24	cells24	NOUN
bptjm-57	57	50	colorectal	colorectal	ADJ
bptjm-57	57	51	cancer	cancer	NOUN
bptjm-57	57	52	apc	apc	PROPN
bptjm-57	57	53	,	,	PUNCT
bptjm-57	57	54	kras	kras	PROPN
bptjm-57	57	55	,	,	PUNCT
bptjm-57	57	56	tp53	tp53	PROPN
bptjm-57	57	57	,	,	PUNCT
bptjm-57	57	58	braf	braf	NOUN
bptjm-57	57	59	mutations25	mutations25	NOUN
bptjm-57	57	60	stem	stem	NOUN
bptjm-57	57	61	-	-	PUNCT
bptjm-57	57	62	like	like	ADJ
bptjm-57	57	63	cells	cell	NOUN
bptjm-57	57	64	,	,	PUNCT
bptjm-57	57	65	di	di	NOUN
bptjm-57	57	66	�	�	PROPN
bptjm-57	57	67	erentiated	erentiate	VERB
bptjm-57	57	68	cells	cell	NOUN
bptjm-57	57	69	,	,	PUNCT
bptjm-57	57	70	tumor	tumor	NOUN
bptjm-57	57	71	-	-	PUNCT
bptjm-57	57	72	in	in	ADP
bptjm-57	57	73	�	�	PROPN
bptjm-57	57	74	ltrating	ltrating	NOUN
bptjm-57	57	75	lymphocytes26	lymphocytes26	PROPN
bptjm-57	57	76	berkeley	berkeley	PROPN
bptjm-57	57	77	pharma	pharma	PROPN
bptjm-57	57	78	tech	tech	NOUN
bptjm-57	57	79	journal	journal	NOUN
bptjm-57	57	80	of	of	ADP
bptjm-57	57	81	medicine	medicine	NOUN
bptjm-57	57	82	|	|	ADV
bptjm-57	57	83	89	89	NUM
bptjm-57	57	84	prostate	prostate	NOUN
bptjm-57	57	85	cancer	cancer	NOUN
bptjm-57	57	86	pten	pten	NOUN
bptjm-57	57	87	,	,	PUNCT
bptjm-57	57	88	tp53	tp53	PROPN
bptjm-57	57	89	,	,	PUNCT
bptjm-57	57	90	ar	ar	PROPN
bptjm-57	57	91	alterations27	alterations27	PROPN
bptjm-57	57	92	adenocarcinoma	adenocarcinoma	PROPN
bptjm-57	57	93	cells	cell	NOUN
bptjm-57	57	94	,	,	PUNCT
bptjm-57	57	95	neuroendocrine	neuroendocrine	ADJ
bptjm-57	57	96	cells	cell	NOUN
bptjm-57	57	97	,	,	PUNCT
bptjm-57	57	98	cancer	cancer	NOUN
bptjm-57	57	99	stem	stem	NOUN
bptjm-57	57	100	cells28,29	cells28,29	NOUN
bptjm-57	57	101	bone	bone	NOUN
bptjm-57	57	102	cancer	cancer	NOUN
bptjm-57	57	103	(	(	PUNCT
bptjm-57	57	104	osteosarcoma	osteosarcoma	X
bptjm-57	57	105	)	)	PUNCT
bptjm-57	57	106	tp53	tp53	PROPN
bptjm-57	57	107	,	,	PUNCT
bptjm-57	57	108	rb1	rb1	PROPN
bptjm-57	57	109	,	,	PUNCT
bptjm-57	57	110	p16ink4a	p16ink4a	PROPN
bptjm-57	57	111	variations30	variations30	VERB
bptjm-57	57	112	osteoblastic	osteoblastic	ADJ
bptjm-57	57	113	cells	cell	NOUN
bptjm-57	57	114	,	,	PUNCT
bptjm-57	57	115	chondroblastic	chondroblastic	ADJ
bptjm-57	57	116	cells	cell	NOUN
bptjm-57	57	117	,	,	PUNCT
bptjm-57	57	118	�	�	PROPN
bptjm-57	57	119	broblastic	broblastic	ADJ
bptjm-57	57	120	cells31	cells31	NOUN
bptjm-57	57	121	table	table	NOUN
bptjm-57	57	122	2	2	NUM
bptjm-57	57	123	.	.	PUNCT
bptjm-57	58	1	genetic	genetic	ADJ
bptjm-57	58	2	and	and	CCONJ
bptjm-57	58	3	cellular	cellular	ADJ
bptjm-57	58	4	heterogeneity	heterogeneity	NOUN
bptjm-57	58	5	of	of	ADP
bptjm-57	58	6	di	di	NOUN
bptjm-57	58	7	�	�	PROPN
bptjm-57	58	8	erent	erent	NOUN
bptjm-57	58	9	types	type	NOUN
bptjm-57	58	10	of	of	ADP
bptjm-57	58	11	cancers	cancer	NOUN
bptjm-57	58	12	.	.	PUNCT
bptjm-57	59	1	this	this	DET
bptjm-57	59	2	table	table	NOUN
bptjm-57	59	3	illustrates	illustrate	VERB
bptjm-57	59	4	genetic	genetic	ADJ
bptjm-57	59	5	and	and	CCONJ
bptjm-57	59	6	cellular	cellular	ADJ
bptjm-57	59	7	heterogeneity	heterogeneity	NOUN
bptjm-57	59	8	of	of	ADP
bptjm-57	59	9	di	di	NOUN
bptjm-57	59	10	�	�	PROPN
bptjm-57	59	11	erent	erent	NOUN
bptjm-57	59	12	types	type	NOUN
bptjm-57	59	13	of	of	ADP
bptjm-57	59	14	cancers	cancer	NOUN
bptjm-57	59	15	.	.	PUNCT
bptjm-57	60	1	column	column	NOUN
bptjm-57	60	2	1	1	NUM
bptjm-57	60	3	identi	identi	X
bptjm-57	60	4	�	�	NOUN
bptjm-57	60	5	es	es	ADJ
bptjm-57	60	6	cancer	cancer	NOUN
bptjm-57	60	7	types	type	NOUN
bptjm-57	60	8	,	,	PUNCT
bptjm-57	60	9	column	column	NOUN
bptjm-57	60	10	2	2	NUM
bptjm-57	60	11	indicates	indicate	VERB
bptjm-57	60	12	genetic	genetic	ADJ
bptjm-57	60	13	heterogeneity	heterogeneity	NOUN
bptjm-57	60	14	,	,	PUNCT
bptjm-57	60	15	and	and	CCONJ
bptjm-57	60	16	the	the	DET
bptjm-57	60	17	last	last	ADJ
bptjm-57	60	18	column	column	NOUN
bptjm-57	60	19	shows	show	VERB
bptjm-57	60	20	cellular	cellular	ADJ
bptjm-57	60	21	heterogeneity	heterogeneity	NOUN
bptjm-57	60	22	.	.	PUNCT
bptjm-57	61	1	the	the	DET
bptjm-57	61	2	presence	presence	NOUN
bptjm-57	61	3	of	of	ADP
bptjm-57	61	4	ith	ith	PROPN
bptjm-57	61	5	across	across	ADP
bptjm-57	61	6	these	these	DET
bptjm-57	61	7	di	di	NOUN
bptjm-57	61	8	�	�	PROPN
bptjm-57	61	9	erent	erent	NOUN
bptjm-57	61	10	types	type	NOUN
bptjm-57	61	11	of	of	ADP
bptjm-57	61	12	cancers	cancer	NOUN
bptjm-57	61	13	emphasizes	emphasize	VERB
bptjm-57	61	14	the	the	DET
bptjm-57	61	15	signi	signi	PROPN
bptjm-57	61	16	�	�	NOUN
bptjm-57	61	17	cance	cance	NOUN
bptjm-57	61	18	of	of	ADP
bptjm-57	61	19	personalized	personalized	ADJ
bptjm-57	61	20	treatment	treatment	NOUN
bptjm-57	61	21	approaches	approach	NOUN
bptjm-57	61	22	.	.	PUNCT
bptjm-57	62	1	understanding	understand	VERB
bptjm-57	62	2	a	a	DET
bptjm-57	62	3	tumor	tumor	NOUN
bptjm-57	62	4	’s	’s	PART
bptjm-57	62	5	unique	unique	ADJ
bptjm-57	62	6	genetic	genetic	ADJ
bptjm-57	62	7	and	and	CCONJ
bptjm-57	62	8	cellular	cellular	ADJ
bptjm-57	62	9	landscapes	landscape	NOUN
bptjm-57	62	10	can	can	AUX
bptjm-57	62	11	guide	guide	VERB
bptjm-57	62	12	the	the	DET
bptjm-57	62	13	selection	selection	NOUN
bptjm-57	62	14	of	of	ADP
bptjm-57	62	15	appropriate	appropriate	ADJ
bptjm-57	62	16	therapies	therapy	NOUN
bptjm-57	62	17	that	that	PRON
bptjm-57	62	18	target	target	VERB
bptjm-57	62	19	speci	speci	ADJ
bptjm-57	62	20	�	�	PROPN
bptjm-57	62	21	c	c	NOUN
bptjm-57	62	22	cell	cell	NOUN
bptjm-57	62	23	populations	population	NOUN
bptjm-57	62	24	or	or	CCONJ
bptjm-57	62	25	overcome	overcome	VERB
bptjm-57	62	26	resistance	resistance	NOUN
bptjm-57	62	27	mechanisms	mechanism	NOUN
bptjm-57	62	28	.	.	PUNCT
bptjm-57	63	1	integrating	integrate	VERB
bptjm-57	63	2	technologies	technology	NOUN
bptjm-57	63	3	like	like	ADP
bptjm-57	63	4	single	single	ADJ
bptjm-57	63	5	-	-	PUNCT
bptjm-57	63	6	cell	cell	NOUN
bptjm-57	63	7	analysis	analysis	NOUN
bptjm-57	63	8	and	and	CCONJ
bptjm-57	63	9	spatial	spatial	ADJ
bptjm-57	63	10	pro	pro	ADJ
bptjm-57	63	11	�	�	PROPN
bptjm-57	63	12	ling	ling	ADJ
bptjm-57	63	13	techniques	technique	NOUN
bptjm-57	63	14	allows	allow	VERB
bptjm-57	63	15	for	for	ADP
bptjm-57	63	16	a	a	DET
bptjm-57	63	17	comprehensive	comprehensive	ADJ
bptjm-57	63	18	assessment	assessment	NOUN
bptjm-57	63	19	of	of	ADP
bptjm-57	63	20	ith	ith	NOUN
bptjm-57	63	21	and	and	CCONJ
bptjm-57	63	22	aids	aid	NOUN
bptjm-57	63	23	in	in	ADP
bptjm-57	63	24	the	the	DET
bptjm-57	63	25	development	development	NOUN
bptjm-57	63	26	of	of	ADP
bptjm-57	63	27	tailored	tailor	VERB
bptjm-57	63	28	treatment	treatment	NOUN
bptjm-57	63	29	strategies.37	strategies.37	NOUN
bptjm-57	63	30	2.3	2.3	NUM
bptjm-57	63	31	determining	determine	VERB
bptjm-57	63	32	the	the	DET
bptjm-57	63	33	degree	degree	NOUN
bptjm-57	63	34	of	of	ADP
bptjm-57	63	35	tumor	tumor	NOUN
bptjm-57	63	36	heterogeneity	heterogeneity	NOUN
bptjm-57	63	37	a	a	DET
bptjm-57	63	38	tumor	tumor	NOUN
bptjm-57	63	39	’s	’s	PART
bptjm-57	63	40	degree	degree	NOUN
bptjm-57	63	41	of	of	ADP
bptjm-57	63	42	heterogeneity	heterogeneity	NOUN
bptjm-57	63	43	is	be	AUX
bptjm-57	63	44	correlated	correlate	VERB
bptjm-57	63	45	with	with	ADP
bptjm-57	63	46	tumor	tumor	NOUN
bptjm-57	63	47	prognosis	prognosis	NOUN
bptjm-57	63	48	,	,	PUNCT
bptjm-57	63	49	genomic	genomic	ADJ
bptjm-57	63	50	instability	instability	NOUN
bptjm-57	63	51	,	,	PUNCT
bptjm-57	63	52	tumor	tumor	NOUN
bptjm-57	63	53	advancement	advancement	NOUN
bptjm-57	63	54	,	,	PUNCT
bptjm-57	63	55	and	and	CCONJ
bptjm-57	63	56	immunosuppression	immunosuppression	NOUN
bptjm-57	63	57	.	.	PUNCT
bptjm-57	64	1	higher	high	ADJ
bptjm-57	64	2	levels	level	NOUN
bptjm-57	64	3	of	of	ADP
bptjm-57	64	4	heterogeneity	heterogeneity	NOUN
bptjm-57	64	5	(	(	PUNCT
bptjm-57	64	6	i.e.	i.e.	X
bptjm-57	64	7	a	a	DET
bptjm-57	64	8	tumor	tumor	NOUN
bptjm-57	64	9	with	with	ADP
bptjm-57	64	10	a	a	DET
bptjm-57	64	11	greater	great	ADJ
bptjm-57	64	12	cell	cell	NOUN
bptjm-57	64	13	diversity	diversity	NOUN
bptjm-57	64	14	)	)	PUNCT
bptjm-57	64	15	suggests	suggest	VERB
bptjm-57	64	16	that	that	SCONJ
bptjm-57	64	17	the	the	DET
bptjm-57	64	18	patient	patient	NOUN
bptjm-57	64	19	is	be	AUX
bptjm-57	64	20	more	more	ADV
bptjm-57	64	21	likely	likely	ADJ
bptjm-57	64	22	to	to	PART
bptjm-57	64	23	experience	experience	VERB
bptjm-57	64	24	worse	bad	ADJ
bptjm-57	64	25	treatment	treatment	NOUN
bptjm-57	64	26	outcomes	outcome	NOUN
bptjm-57	64	27	and	and	CCONJ
bptjm-57	64	28	drug	drug	NOUN
bptjm-57	64	29	resistance	resistance	NOUN
bptjm-57	64	30	.	.	PUNCT
bptjm-57	65	1	knowing	know	VERB
bptjm-57	65	2	the	the	DET
bptjm-57	65	3	level	level	NOUN
bptjm-57	65	4	of	of	ADP
bptjm-57	65	5	heterogeneity	heterogeneity	NOUN
bptjm-57	65	6	a	a	DET
bptjm-57	65	7	tumor	tumor	NOUN
bptjm-57	65	8	possesses	possesse	NOUN
bptjm-57	65	9	permits	permit	VERB
bptjm-57	65	10	researchers	researcher	NOUN
bptjm-57	65	11	to	to	PART
bptjm-57	65	12	begin	begin	VERB
bptjm-57	65	13	planning	plan	VERB
bptjm-57	65	14	specialized	specialized	ADJ
bptjm-57	65	15	treatments	treatment	NOUN
bptjm-57	65	16	since	since	SCONJ
bptjm-57	65	17	more	more	ADJ
bptjm-57	65	18	diversity	diversity	NOUN
bptjm-57	65	19	in	in	ADP
bptjm-57	65	20	the	the	DET
bptjm-57	65	21	cell	cell	NOUN
bptjm-57	65	22	population	population	NOUN
bptjm-57	65	23	demands	demand	VERB
bptjm-57	65	24	a	a	DET
bptjm-57	65	25	more	more	ADV
bptjm-57	65	26	personalized	personalized	ADJ
bptjm-57	65	27	treatment	treatment	NOUN
bptjm-57	65	28	.	.	PUNCT
bptjm-57	66	1	this	this	DET
bptjm-57	66	2	knowledge	knowledge	NOUN
bptjm-57	66	3	also	also	ADV
bptjm-57	66	4	permits	permit	VERB
bptjm-57	66	5	studies	study	NOUN
bptjm-57	66	6	to	to	PART
bptjm-57	66	7	be	be	AUX
bptjm-57	66	8	done	do	VERB
bptjm-57	66	9	on	on	ADP
bptjm-57	66	10	groups	group	NOUN
bptjm-57	66	11	with	with	ADP
bptjm-57	66	12	high	high	ADJ
bptjm-57	66	13	and	and	CCONJ
bptjm-57	66	14	low	low	ADJ
bptjm-57	66	15	levels	level	NOUN
bptjm-57	66	16	of	of	ADP
bptjm-57	66	17	heterogeneity	heterogeneity	NOUN
bptjm-57	66	18	in	in	ADP
bptjm-57	66	19	order	order	NOUN
bptjm-57	66	20	to	to	PART
bptjm-57	66	21	determine	determine	VERB
bptjm-57	66	22	the	the	DET
bptjm-57	66	23	impact	impact	NOUN
bptjm-57	66	24	of	of	ADP
bptjm-57	66	25	ith	ith	NOUN
bptjm-57	66	26	on	on	ADP
bptjm-57	66	27	a	a	DET
bptjm-57	66	28	speci	speci	ADJ
bptjm-57	66	29	�	�	PROPN
bptjm-57	66	30	c	c	PROPN
bptjm-57	66	31	treatment.36	treatment.36	NOUN
bptjm-57	66	32	research	research	NOUN
bptjm-57	66	33	has	have	AUX
bptjm-57	66	34	determined	determine	VERB
bptjm-57	66	35	that	that	SCONJ
bptjm-57	66	36	three	three	NUM
bptjm-57	66	37	methods	method	NOUN
bptjm-57	66	38	are	be	AUX
bptjm-57	66	39	the	the	DET
bptjm-57	66	40	most	most	ADV
bptjm-57	66	41	accurate	accurate	ADJ
bptjm-57	66	42	and	and	CCONJ
bptjm-57	66	43	e	e	NOUN
bptjm-57	66	44	�	�	NOUN
bptjm-57	66	45	ective	ective	NOUN
bptjm-57	66	46	regarding	regard	VERB
bptjm-57	66	47	how	how	SCONJ
bptjm-57	66	48	closely	closely	ADV
bptjm-57	66	49	correlated	correlate	VERB
bptjm-57	66	50	they	they	PRON
bptjm-57	66	51	are	be	AUX
bptjm-57	66	52	with	with	ADP
bptjm-57	66	53	heterogeneity	heterogeneity	PROPN
bptjm-57	66	54	berkeley	berkeley	PROPN
bptjm-57	66	55	pharma	pharma	PROPN
bptjm-57	66	56	tech	tech	NOUN
bptjm-57	66	57	journal	journal	NOUN
bptjm-57	66	58	of	of	ADP
bptjm-57	66	59	medicine	medicine	NOUN
bptjm-57	66	60	|	|	ADV
bptjm-57	66	61	90	90	NUM
bptjm-57	66	62	outcomes	outcome	NOUN
bptjm-57	66	63	:	:	PUNCT
bptjm-57	66	64	depth38	depth38	NOUN
bptjm-57	66	65	,	,	PUNCT
bptjm-57	66	66	depth239	depth239	PROPN
bptjm-57	66	67	,	,	PUNCT
bptjm-57	66	68	and	and	CCONJ
bptjm-57	66	69	tith40	tith40	PROPN
bptjm-57	66	70	,	,	PUNCT
bptjm-57	66	71	which	which	DET
bptjm-57	66	72	all	all	PRON
bptjm-57	66	73	have	have	VERB
bptjm-57	66	74	comparable	comparable	ADJ
bptjm-57	66	75	performances	performance	NOUN
bptjm-57	66	76	.	.	PUNCT
bptjm-57	67	1	these	these	DET
bptjm-57	67	2	newer	new	ADJ
bptjm-57	67	3	algorithms	algorithms	PROPN
bptjm-57	67	4	di	di	NOUN
bptjm-57	67	5	�	�	PROPN
bptjm-57	67	6	er	er	NUM
bptjm-57	67	7	from	from	ADP
bptjm-57	67	8	those	those	PRON
bptjm-57	67	9	used	use	VERB
bptjm-57	67	10	in	in	ADP
bptjm-57	67	11	previous	previous	ADJ
bptjm-57	67	12	studies	study	NOUN
bptjm-57	67	13	in	in	ADP
bptjm-57	67	14	that	that	SCONJ
bptjm-57	67	15	they	they	PRON
bptjm-57	67	16	implement	implement	VERB
bptjm-57	67	17	rna	rna	NOUN
bptjm-57	67	18	sequencing	sequencing	NOUN
bptjm-57	67	19	as	as	SCONJ
bptjm-57	67	20	opposed	oppose	VERB
bptjm-57	67	21	to	to	ADP
bptjm-57	67	22	dna	dna	PROPN
bptjm-57	67	23	sequencing	sequencing	NOUN
bptjm-57	67	24	.	.	PUNCT
bptjm-57	68	1	experiments	experiment	NOUN
bptjm-57	68	2	using	use	VERB
bptjm-57	68	3	depth	depth	NOUN
bptjm-57	68	4	,	,	PUNCT
bptjm-57	68	5	which	which	PRON
bptjm-57	68	6	stands	stand	VERB
bptjm-57	68	7	for	for	ADP
bptjm-57	68	8	deviating	deviate	VERB
bptjm-57	68	9	gene	gene	NOUN
bptjm-57	68	10	expression	expression	NOUN
bptjm-57	68	11	pro	pro	ADJ
bptjm-57	68	12	�	�	PROPN
bptjm-57	68	13	ling	ling	ADJ
bptjm-57	68	14	tumor	tumor	NOUN
bptjm-57	68	15	heterogeneity	heterogeneity	NOUN
bptjm-57	68	16	,	,	PUNCT
bptjm-57	68	17	were	be	AUX
bptjm-57	68	18	conducted	conduct	VERB
bptjm-57	68	19	for	for	ADP
bptjm-57	68	20	over	over	ADP
bptjm-57	68	21	25	25	NUM
bptjm-57	68	22	cancer	cancer	NOUN
bptjm-57	68	23	types	type	NOUN
bptjm-57	68	24	alongside	alongside	ADP
bptjm-57	68	25	10,000	10,000	NUM
bptjm-57	68	26	samples	sample	NOUN
bptjm-57	68	27	of	of	ADP
bptjm-57	68	28	tcga	tcga	ADJ
bptjm-57	68	29	pan	pan	NOUN
bptjm-57	68	30	-	-	NOUN
bptjm-57	68	31	cancer	cancer	NOUN
bptjm-57	68	32	.	.	PUNCT
bptjm-57	69	1	depth	depth	NOUN
bptjm-57	69	2	showed	show	VERB
bptjm-57	69	3	stronger	strong	ADJ
bptjm-57	69	4	correlations	correlation	NOUN
bptjm-57	69	5	between	between	ADP
bptjm-57	69	6	tumor	tumor	NOUN
bptjm-57	69	7	prognosis	prognosis	NOUN
bptjm-57	69	8	and	and	CCONJ
bptjm-57	69	9	anti	anti	ADJ
bptjm-57	69	10	-	-	ADJ
bptjm-57	69	11	tumor	tumor	ADJ
bptjm-57	69	12	heterogeneity	heterogeneity	NOUN
bptjm-57	69	13	than	than	ADP
bptjm-57	69	14	dna	dna	NOUN
bptjm-57	69	15	-	-	PUNCT
bptjm-57	69	16	based	base	VERB
bptjm-57	69	17	algorithms	algorithm	NOUN
bptjm-57	69	18	such	such	ADJ
bptjm-57	69	19	as	as	ADP
bptjm-57	69	20	absolute	absolute	ADJ
bptjm-57	69	21	,	,	PUNCT
bptjm-57	69	22	expands	expand	VERB
bptjm-57	69	23	,	,	PUNCT
bptjm-57	69	24	math	math	NOUN
bptjm-57	69	25	,	,	PUNCT
bptjm-57	69	26	and	and	CCONJ
bptjm-57	69	27	phylowgs.38	phylowgs.38	PROPN
bptjm-57	69	28	depth2	depth2	NOUN
bptjm-57	69	29	showed	show	VERB
bptjm-57	69	30	similar	similar	ADJ
bptjm-57	69	31	correlations	correlation	NOUN
bptjm-57	69	32	to	to	ADP
bptjm-57	69	33	the	the	DET
bptjm-57	69	34	original	original	ADJ
bptjm-57	69	35	depth	depth	NOUN
bptjm-57	69	36	program	program	NOUN
bptjm-57	69	37	,	,	PUNCT
bptjm-57	69	38	but	but	CCONJ
bptjm-57	69	39	it	it	PRON
bptjm-57	69	40	had	have	VERB
bptjm-57	69	41	the	the	DET
bptjm-57	69	42	advantage	advantage	NOUN
bptjm-57	69	43	of	of	ADP
bptjm-57	69	44	being	be	AUX
bptjm-57	69	45	applicable	applicable	ADJ
bptjm-57	69	46	to	to	ADP
bptjm-57	69	47	more	more	ADJ
bptjm-57	69	48	gene	gene	NOUN
bptjm-57	69	49	expression	expression	NOUN
bptjm-57	69	50	pro	pro	X
bptjm-57	69	51	�	�	VERB
bptjm-57	69	52	les	le	NOUN
bptjm-57	69	53	as	as	SCONJ
bptjm-57	69	54	it	it	PRON
bptjm-57	69	55	does	do	AUX
bptjm-57	69	56	not	not	PART
bptjm-57	69	57	reference	reference	VERB
bptjm-57	69	58	normal	normal	ADJ
bptjm-57	69	59	controls	control	NOUN
bptjm-57	69	60	like	like	ADP
bptjm-57	69	61	other	other	ADJ
bptjm-57	69	62	mrna	mrna	NOUN
bptjm-57	69	63	or	or	CCONJ
bptjm-57	69	64	dna	dna	PROPN
bptjm-57	69	65	-	-	PUNCT
bptjm-57	69	66	based	base	VERB
bptjm-57	69	67	algorithms.39depth2	algorithms.39depth2	PROPN
bptjm-57	69	68	was	be	AUX
bptjm-57	69	69	used	use	VERB
bptjm-57	69	70	in	in	ADP
bptjm-57	69	71	a	a	DET
bptjm-57	69	72	recent	recent	ADJ
bptjm-57	69	73	2022	2022	NUM
bptjm-57	69	74	study	study	NOUN
bptjm-57	69	75	to	to	ADP
bptjm-57	69	76	separate	separate	ADJ
bptjm-57	69	77	groups	group	NOUN
bptjm-57	69	78	into	into	ADP
bptjm-57	69	79	high	high	ADJ
bptjm-57	69	80	and	and	CCONJ
bptjm-57	69	81	low	low	ADJ
bptjm-57	69	82	intratumor	intratumor	NOUN
bptjm-57	69	83	heterogeneity	heterogeneity	NOUN
bptjm-57	69	84	groups	group	NOUN
bptjm-57	69	85	.	.	PUNCT
bptjm-57	70	1	these	these	DET
bptjm-57	70	2	groups	group	NOUN
bptjm-57	70	3	were	be	AUX
bptjm-57	70	4	then	then	ADV
bptjm-57	70	5	compared	compare	VERB
bptjm-57	70	6	in	in	ADP
bptjm-57	70	7	a	a	DET
bptjm-57	70	8	study	study	NOUN
bptjm-57	70	9	to	to	PART
bptjm-57	70	10	determine	determine	VERB
bptjm-57	70	11	a	a	DET
bptjm-57	70	12	correlation	correlation	NOUN
bptjm-57	70	13	between	between	ADP
bptjm-57	70	14	heterogeneity	heterogeneity	NOUN
bptjm-57	70	15	and	and	CCONJ
bptjm-57	70	16	chemotherapy	chemotherapy	NOUN
bptjm-57	70	17	response	response	NOUN
bptjm-57	70	18	in	in	ADP
bptjm-57	70	19	patients	patient	NOUN
bptjm-57	70	20	with	with	ADP
bptjm-57	70	21	colon	colon	NOUN
bptjm-57	70	22	adenocarcinoma.41	adenocarcinoma.41	NOUN
bptjm-57	70	23	finally	finally	ADV
bptjm-57	70	24	,	,	PUNCT
bptjm-57	70	25	transcriptome	transcriptome	PROPN
bptjm-57	70	26	-	-	PUNCT
bptjm-57	70	27	based	base	VERB
bptjm-57	70	28	ith	ith	NOUN
bptjm-57	70	29	(	(	PUNCT
bptjm-57	70	30	tith	tith	PROPN
bptjm-57	70	31	)	)	PUNCT
bptjm-57	70	32	involves	involve	VERB
bptjm-57	70	33	de	de	PROPN
bptjm-57	70	34	�	�	NOUN
bptjm-57	70	35	ning	ning	NOUN
bptjm-57	70	36	a	a	DET
bptjm-57	70	37	network	network	NOUN
bptjm-57	70	38	and	and	CCONJ
bptjm-57	70	39	determining	determine	VERB
bptjm-57	70	40	the	the	DET
bptjm-57	70	41	distance	distance	NOUN
bptjm-57	70	42	between	between	ADP
bptjm-57	70	43	typical	typical	ADJ
bptjm-57	70	44	genetic	genetic	ADJ
bptjm-57	70	45	sequences	sequence	NOUN
bptjm-57	70	46	and	and	CCONJ
bptjm-57	70	47	cancer	cancer	NOUN
bptjm-57	70	48	sequences	sequence	NOUN
bptjm-57	70	49	.	.	PUNCT
bptjm-57	71	1	pathway	pathway	NOUN
bptjm-57	71	2	-	-	PUNCT
bptjm-57	71	3	tith	tith	PROPN
bptjm-57	71	4	is	be	AUX
bptjm-57	71	5	de	de	X
bptjm-57	71	6	�	�	NOUN
bptjm-57	71	7	ned	ne	VERB
bptjm-57	71	8	using	use	VERB
bptjm-57	71	9	the	the	DET
bptjm-57	71	10	genes	gene	NOUN
bptjm-57	71	11	from	from	ADP
bptjm-57	71	12	one	one	NUM
bptjm-57	71	13	speci	speci	ADJ
bptjm-57	71	14	�	�	PROPN
bptjm-57	71	15	ed	ed	PROPN
bptjm-57	71	16	pathway	pathway	NOUN
bptjm-57	71	17	.	.	PUNCT
bptjm-57	72	1	one	one	NUM
bptjm-57	72	2	study	study	NOUN
bptjm-57	72	3	demonstrated	demonstrate	VERB
bptjm-57	72	4	that	that	SCONJ
bptjm-57	72	5	in	in	ADP
bptjm-57	72	6	255	255	NUM
bptjm-57	72	7	out	out	ADP
bptjm-57	72	8	of	of	ADP
bptjm-57	72	9	291	291	NUM
bptjm-57	72	10	pathways	pathway	NOUN
bptjm-57	72	11	,	,	PUNCT
bptjm-57	72	12	genomic	genomic	ADJ
bptjm-57	72	13	ith	ith	PROPN
bptjm-57	72	14	was	be	AUX
bptjm-57	72	15	strongly	strongly	ADV
bptjm-57	72	16	correlated	correlate	VERB
bptjm-57	72	17	with	with	ADP
bptjm-57	72	18	pathway	pathway	NOUN
bptjm-57	72	19	-	-	PUNCT
bptjm-57	72	20	tith	tith	NOUN
bptjm-57	72	21	,	,	PUNCT
bptjm-57	72	22	supporting	support	VERB
bptjm-57	72	23	earlier	early	ADJ
bptjm-57	72	24	�	�	NOUN
bptjm-57	72	25	ndings	nding	NOUN
bptjm-57	72	26	that	that	SCONJ
bptjm-57	72	27	overall	overall	ADJ
bptjm-57	72	28	genetic	genetic	ADJ
bptjm-57	72	29	diversity	diversity	NOUN
bptjm-57	72	30	impacts	impact	VERB
bptjm-57	72	31	variation	variation	NOUN
bptjm-57	72	32	in	in	ADP
bptjm-57	72	33	certain	certain	ADJ
bptjm-57	72	34	pathways.40	pathways.40	PROPN
bptjm-57	72	35	table	table	NOUN
bptjm-57	72	36	3	3	NUM
bptjm-57	72	37	below	below	SCONJ
bptjm-57	72	38	displays	display	VERB
bptjm-57	72	39	information	information	NOUN
bptjm-57	72	40	on	on	ADP
bptjm-57	72	41	the	the	DET
bptjm-57	72	42	dna	dna	NOUN
bptjm-57	72	43	-	-	PUNCT
bptjm-57	72	44	based	base	VERB
bptjm-57	72	45	algorithms	algorithm	NOUN
bptjm-57	72	46	used	use	VERB
bptjm-57	72	47	in	in	ADP
bptjm-57	72	48	earlier	early	ADJ
bptjm-57	72	49	studies	study	NOUN
bptjm-57	72	50	,	,	PUNCT
bptjm-57	72	51	as	as	ADV
bptjm-57	72	52	well	well	ADV
bptjm-57	72	53	as	as	ADP
bptjm-57	72	54	the	the	DET
bptjm-57	72	55	more	more	ADV
bptjm-57	72	56	recent	recent	ADJ
bptjm-57	72	57	rna	rna	NOUN
bptjm-57	72	58	-	-	PUNCT
bptjm-57	72	59	based	base	VERB
bptjm-57	72	60	algorithms	algorithm	NOUN
bptjm-57	72	61	primarily	primarily	ADV
bptjm-57	72	62	discussed	discuss	VERB
bptjm-57	72	63	in	in	ADP
bptjm-57	72	64	the	the	DET
bptjm-57	72	65	paper	paper	NOUN
bptjm-57	72	66	.	.	PUNCT
bptjm-57	73	1	algorithm	algorithm	NOUN
bptjm-57	73	2	name	name	NOUN
bptjm-57	73	3	description	description	NOUN
bptjm-57	73	4	features	feature	VERB
bptjm-57	73	5	year	year	NOUN
bptjm-57	73	6	created	create	VERB
bptjm-57	73	7	absolute42	absolute42	X
bptjm-57	73	8	pro	pro	ADJ
bptjm-57	73	9	�	�	PROPN
bptjm-57	73	10	les	les	ADJ
bptjm-57	73	11	dna	dna	NOUN
bptjm-57	73	12	from	from	ADP
bptjm-57	73	13	heterogeneous	heterogeneous	ADJ
bptjm-57	73	14	cell	cell	NOUN
bptjm-57	73	15	populations	population	NOUN
bptjm-57	73	16	to	to	PART
bptjm-57	73	17	determine	determine	VERB
bptjm-57	73	18	cellular	cellular	ADJ
bptjm-57	73	19	copy	copy	NOUN
bptjm-57	73	20	number	number	NOUN
bptjm-57	73	21	and	and	CCONJ
bptjm-57	73	22	identify	identify	VERB
bptjm-57	73	23	variant	variant	ADJ
bptjm-57	73	24	alleles	allele	NOUN
bptjm-57	73	25	identi	identi	ADJ
bptjm-57	73	26	�	�	NOUN
bptjm-57	73	27	es	es	NOUN
bptjm-57	73	28	alterations	alteration	NOUN
bptjm-57	73	29	in	in	ADP
bptjm-57	73	30	cancer	cancer	NOUN
bptjm-57	73	31	cells	cell	NOUN
bptjm-57	73	32	evaluates	evaluate	VERB
bptjm-57	73	33	tumor	tumor	NOUN
bptjm-57	73	34	ploidy	ploidy	ADJ
bptjm-57	73	35	estimates	estimate	NOUN
bptjm-57	73	36	2012	2012	NUM
bptjm-57	73	37	berkeley	berkeley	PROPN
bptjm-57	73	38	pharma	pharma	PROPN
bptjm-57	73	39	tech	tech	NOUN
bptjm-57	73	40	journal	journal	NOUN
bptjm-57	73	41	of	of	ADP
bptjm-57	73	42	medicine	medicine	NOUN
bptjm-57	73	43	|	|	ADV
bptjm-57	73	44	91	91	NUM
bptjm-57	73	45	math43	math43	NOUN
bptjm-57	73	46	measures	measure	NOUN
bptjm-57	73	47	intratumor	intratumor	ADJ
bptjm-57	73	48	genetic	genetic	ADJ
bptjm-57	73	49	heterogeneity	heterogeneity	NOUN
bptjm-57	73	50	based	base	VERB
bptjm-57	73	51	on	on	ADP
bptjm-57	73	52	mutant	mutant	ADJ
bptjm-57	73	53	-	-	PUNCT
bptjm-57	73	54	allele	allele	NOUN
bptjm-57	73	55	fraction	fraction	NOUN
bptjm-57	73	56	correlates	correlate	VERB
bptjm-57	73	57	ithwith	ithwith	ADJ
bptjm-57	73	58	mutations	mutation	NOUN
bptjm-57	73	59	in	in	ADP
bptjm-57	73	60	tp53	tp53	PROPN
bptjm-57	73	61	and	and	CCONJ
bptjm-57	73	62	hpv	hpv	NOUN
bptjm-57	73	63	status	status	NOUN
bptjm-57	73	64	2013	2013	NUM
bptjm-57	73	65	expands44	expands44	NOUN
bptjm-57	73	66	characterizes	characterize	VERB
bptjm-57	73	67	coexisting	coexist	VERB
bptjm-57	73	68	tumor	tumor	NOUN
bptjm-57	73	69	subpopulations	subpopulation	NOUN
bptjm-57	73	70	using	use	VERB
bptjm-57	73	71	copy	copy	NOUN
bptjm-57	73	72	number	number	NOUN
bptjm-57	73	73	and	and	CCONJ
bptjm-57	73	74	allele	allele	NOUN
bptjm-57	73	75	frequencies	frequency	NOUN
bptjm-57	73	76	estimates	estimate	VERB
bptjm-57	73	77	tumor	tumor	NOUN
bptjm-57	73	78	purity	purity	NOUN
bptjm-57	73	79	and	and	CCONJ
bptjm-57	73	80	predicts	predict	VERB
bptjm-57	73	81	clonal	clonal	ADJ
bptjm-57	73	82	subpopulations	subpopulation	NOUN
bptjm-57	73	83	quanti	quanti	X
bptjm-57	73	84	�	�	PROPN
bptjm-57	73	85	es	es	ADJ
bptjm-57	73	86	genetic	genetic	ADJ
bptjm-57	73	87	ith	ith	PROPN
bptjm-57	73	88	2014	2014	NUM
bptjm-57	73	89	phylowgs45	phylowgs45	NOUN
bptjm-57	73	90	combines	combine	VERB
bptjm-57	73	91	somatic	somatic	ADJ
bptjm-57	73	92	mutation	mutation	NOUN
bptjm-57	73	93	and	and	CCONJ
bptjm-57	73	94	copy	copy	VERB
bptjm-57	73	95	number	number	NOUN
bptjm-57	73	96	information	information	NOUN
bptjm-57	73	97	for	for	ADP
bptjm-57	73	98	subclonal	subclonal	ADJ
bptjm-57	73	99	reconstruction	reconstruction	NOUN
bptjm-57	73	100	provides	provide	VERB
bptjm-57	73	101	complete	complete	ADJ
bptjm-57	73	102	subclonal	subclonal	ADJ
bptjm-57	73	103	reconstruction	reconstruction	NOUN
bptjm-57	73	104	2015	2015	NUM
bptjm-57	73	105	tith40	tith40	NOUN
bptjm-57	73	106	models	model	NOUN
bptjm-57	73	107	gene	gene	NOUN
bptjm-57	73	108	relationships	relationship	NOUN
bptjm-57	73	109	and	and	CCONJ
bptjm-57	73	110	measures	measure	NOUN
bptjm-57	73	111	network	network	NOUN
bptjm-57	73	112	disruptions	disruption	NOUN
bptjm-57	73	113	to	to	PART
bptjm-57	73	114	assess	assess	VERB
bptjm-57	73	115	ith	ith	PROPN
bptjm-57	73	116	shows	show	VERB
bptjm-57	73	117	positive	positive	ADJ
bptjm-57	73	118	correlation	correlation	NOUN
bptjm-57	73	119	with	with	ADP
bptjm-57	73	120	tumor	tumor	NOUN
bptjm-57	73	121	progression	progression	NOUN
bptjm-57	73	122	and	and	CCONJ
bptjm-57	73	123	worse	bad	ADJ
bptjm-57	73	124	survival	survival	NOUN
bptjm-57	73	125	2016	2016	NUM
bptjm-57	73	126	depth38	depth38	NOUN
bptjm-57	73	127	calculates	calculate	NOUN
bptjm-57	73	128	ith	ith	PROPN
bptjm-57	73	129	based	base	VERB
bptjm-57	73	130	on	on	ADP
bptjm-57	73	131	gene	gene	NOUN
bptjm-57	73	132	expression	expression	NOUN
bptjm-57	73	133	pro	pro	X
bptjm-57	73	134	�	�	VERB
bptjm-57	73	135	les	le	NOUN
bptjm-57	73	136	from	from	ADP
bptjm-57	73	137	rna	rna	NOUN
bptjm-57	73	138	sequencing	sequence	VERB
bptjm-57	73	139	data	datum	NOUN
bptjm-57	73	140	is	be	AUX
bptjm-57	73	141	associated	associate	VERB
bptjm-57	73	142	with	with	ADP
bptjm-57	73	143	genomic	genomic	NOUN
bptjm-57	73	144	instability	instability	NOUN
bptjm-57	73	145	,	,	PUNCT
bptjm-57	73	146	worse	bad	ADJ
bptjm-57	73	147	survival	survival	NOUN
bptjm-57	73	148	,	,	PUNCT
bptjm-57	73	149	and	and	CCONJ
bptjm-57	73	150	decreased	decrease	VERB
bptjm-57	73	151	antitumor	antitumor	PROPN
bptjm-57	73	152	immunity	immunity	NOUN
bptjm-57	73	153	2020	2020	NUM
bptjm-57	73	154	depth239	depth239	PROPN
bptjm-57	73	155	calculates	calculate	NOUN
bptjm-57	73	156	ith	ith	PROPN
bptjm-57	73	157	based	base	VERB
bptjm-57	73	158	on	on	ADP
bptjm-57	73	159	disruptions	disruption	NOUN
bptjm-57	73	160	of	of	ADP
bptjm-57	73	161	gene	gene	NOUN
bptjm-57	73	162	expression	expression	NOUN
bptjm-57	73	163	pro	pro	X
bptjm-57	73	164	�	�	VERB
bptjm-57	73	165	les	le	NOUN
bptjm-57	73	166	without	without	SCONJ
bptjm-57	73	167	reference	reference	NOUN
bptjm-57	73	168	controls	control	NOUN
bptjm-57	73	169	is	be	AUX
bptjm-57	73	170	associated	associate	VERB
bptjm-57	73	171	with	with	ADP
bptjm-57	73	172	worse	bad	ADJ
bptjm-57	73	173	survival	survival	NOUN
bptjm-57	73	174	and	and	CCONJ
bptjm-57	73	175	more	more	ADV
bptjm-57	73	176	aggressive	aggressive	ADJ
bptjm-57	73	177	cancer	cancer	NOUN
bptjm-57	73	178	subtypes	subtype	NOUN
bptjm-57	73	179	2022	2022	NUM
bptjm-57	73	180	table	table	NOUN
bptjm-57	73	181	3	3	NUM
bptjm-57	73	182	.	.	PUNCT
bptjm-57	74	1	algorithms	algorithm	NOUN
bptjm-57	74	2	used	use	VERB
bptjm-57	74	3	to	to	PART
bptjm-57	74	4	assess	assess	VERB
bptjm-57	74	5	tumor	tumor	NOUN
bptjm-57	74	6	heterogeneity	heterogeneity	NOUN
bptjm-57	74	7	.	.	PUNCT
bptjm-57	75	1	this	this	DET
bptjm-57	75	2	table	table	NOUN
bptjm-57	75	3	lists	list	VERB
bptjm-57	75	4	the	the	DET
bptjm-57	75	5	algorithms	algorithm	NOUN
bptjm-57	75	6	that	that	PRON
bptjm-57	75	7	are	be	AUX
bptjm-57	75	8	used	use	VERB
bptjm-57	75	9	to	to	PART
bptjm-57	75	10	assess	assess	VERB
bptjm-57	75	11	tumor	tumor	NOUN
bptjm-57	75	12	heterogeneity	heterogeneity	NOUN
bptjm-57	75	13	in	in	ADP
bptjm-57	75	14	order	order	NOUN
bptjm-57	75	15	of	of	ADP
bptjm-57	75	16	the	the	DET
bptjm-57	75	17	year	year	NOUN
bptjm-57	75	18	it	it	PRON
bptjm-57	75	19	was	be	AUX
bptjm-57	75	20	created	create	VERB
bptjm-57	75	21	.	.	PUNCT
bptjm-57	76	1	it	it	PRON
bptjm-57	76	2	also	also	ADV
bptjm-57	76	3	explains	explain	VERB
bptjm-57	76	4	how	how	SCONJ
bptjm-57	76	5	each	each	DET
bptjm-57	76	6	algorithm	algorithm	NOUN
bptjm-57	76	7	works	work	VERB
bptjm-57	76	8	and	and	CCONJ
bptjm-57	76	9	what	what	PRON
bptjm-57	76	10	it	it	PRON
bptjm-57	76	11	assesses	assess	VERB
bptjm-57	76	12	.	.	PUNCT
bptjm-57	77	1	single	single	ADJ
bptjm-57	77	2	-	-	PUNCT
bptjm-57	77	3	cell	cell	NOUN
bptjm-57	77	4	rna	rna	NOUN
bptjm-57	77	5	sequencing	sequence	VERB
bptjm-57	77	6	(	(	PUNCT
bptjm-57	77	7	scrna	scrna	NOUN
bptjm-57	77	8	-	-	PUNCT
bptjm-57	77	9	seq	seq	NOUN
bptjm-57	77	10	)	)	PUNCT
bptjm-57	77	11	has	have	AUX
bptjm-57	77	12	also	also	ADV
bptjm-57	77	13	shown	show	VERB
bptjm-57	77	14	promise	promise	NOUN
bptjm-57	77	15	in	in	ADP
bptjm-57	77	16	helping	helping	AUX
bptjm-57	77	17	develop	develop	VERB
bptjm-57	77	18	personalized	personalized	ADJ
bptjm-57	77	19	treatment	treatment	NOUN
bptjm-57	77	20	plans	plan	NOUN
bptjm-57	77	21	.	.	PUNCT
bptjm-57	78	1	scrna	scrna	NOUN
bptjm-57	78	2	-	-	PUNCT
bptjm-57	78	3	seq	seq	NOUN
bptjm-57	78	4	works	work	NOUN
bptjm-57	78	5	by	by	ADP
bptjm-57	78	6	isolating	isolate	VERB
bptjm-57	78	7	the	the	DET
bptjm-57	78	8	tumor	tumor	NOUN
bptjm-57	78	9	cells	cell	NOUN
bptjm-57	78	10	and	and	CCONJ
bptjm-57	78	11	running	run	VERB
bptjm-57	78	12	mrna	mrna	PROPN
bptjm-57	78	13	reverse	reverse	NOUN
bptjm-57	78	14	transcription	transcription	NOUN
bptjm-57	78	15	and	and	CCONJ
bptjm-57	78	16	berkeley	berkeley	PROPN
bptjm-57	78	17	pharma	pharma	PROPN
bptjm-57	78	18	tech	tech	NOUN
bptjm-57	78	19	journal	journal	NOUN
bptjm-57	78	20	of	of	ADP
bptjm-57	78	21	medicine	medicine	NOUN
bptjm-57	78	22	|	|	ADV
bptjm-57	78	23	92	92	NUM
bptjm-57	78	24	cdna	cdna	PROPN
bptjm-57	78	25	ampli	ampli	NOUN
bptjm-57	78	26	�	�	NOUN
bptjm-57	78	27	cation	cation	NOUN
bptjm-57	78	28	before	before	ADP
bptjm-57	78	29	sequencing	sequence	VERB
bptjm-57	78	30	.	.	PUNCT
bptjm-57	79	1	as	as	ADV
bptjm-57	79	2	recent	recent	ADJ
bptjm-57	79	3	as	as	ADP
bptjm-57	79	4	2020	2020	NUM
bptjm-57	79	5	,	,	PUNCT
bptjm-57	79	6	single	single	ADJ
bptjm-57	79	7	-	-	PUNCT
bptjm-57	79	8	cell	cell	NOUN
bptjm-57	79	9	rna	rna	NOUN
bptjm-57	79	10	sequencing	sequence	VERB
bptjm-57	79	11	e	e	NOUN
bptjm-57	79	12	�	�	NOUN
bptjm-57	79	13	ciently	ciently	ADV
bptjm-57	79	14	analyzed	analyze	VERB
bptjm-57	79	15	thousands	thousand	NOUN
bptjm-57	79	16	of	of	ADP
bptjm-57	79	17	cells	cell	NOUN
bptjm-57	79	18	at	at	ADP
bptjm-57	79	19	once	once	ADV
bptjm-57	79	20	,	,	PUNCT
bptjm-57	79	21	making	make	VERB
bptjm-57	79	22	it	it	PRON
bptjm-57	79	23	more	more	ADV
bptjm-57	79	24	useful	useful	ADJ
bptjm-57	79	25	for	for	ADP
bptjm-57	79	26	treatment	treatment	NOUN
bptjm-57	79	27	than	than	ADP
bptjm-57	79	28	in	in	ADP
bptjm-57	79	29	previous	previous	ADJ
bptjm-57	79	30	years	year	NOUN
bptjm-57	79	31	.	.	PUNCT
bptjm-57	80	1	a	a	DET
bptjm-57	80	2	study	study	NOUN
bptjm-57	80	3	found	find	VERB
bptjm-57	80	4	that	that	SCONJ
bptjm-57	80	5	scrna	scrna	NOUN
bptjm-57	80	6	-	-	PUNCT
bptjm-57	80	7	seq	seq	NOUN
bptjm-57	80	8	could	could	AUX
bptjm-57	80	9	adequately	adequately	ADV
bptjm-57	80	10	determine	determine	VERB
bptjm-57	80	11	clusters	cluster	NOUN
bptjm-57	80	12	of	of	ADP
bptjm-57	80	13	cells	cell	NOUN
bptjm-57	80	14	associated	associate	VERB
bptjm-57	80	15	with	with	ADP
bptjm-57	80	16	poor	poor	ADJ
bptjm-57	80	17	clinical	clinical	ADJ
bptjm-57	80	18	outcomes	outcome	NOUN
bptjm-57	80	19	and	and	CCONJ
bptjm-57	80	20	�	�	NOUN
bptjm-57	80	21	nd	nd	PRON
bptjm-57	80	22	targets	target	NOUN
bptjm-57	80	23	for	for	ADP
bptjm-57	80	24	immunotherapy	immunotherapy	NOUN
bptjm-57	80	25	treatments	treatment	NOUN
bptjm-57	80	26	in	in	ADP
bptjm-57	80	27	an	an	DET
bptjm-57	80	28	analysis	analysis	NOUN
bptjm-57	80	29	of	of	ADP
bptjm-57	80	30	triple	triple	ADJ
bptjm-57	80	31	-	-	PUNCT
bptjm-57	80	32	negative	negative	ADJ
bptjm-57	80	33	breast	breast	NOUN
bptjm-57	80	34	cancer	cancer	NOUN
bptjm-57	80	35	(	(	PUNCT
bptjm-57	80	36	tnbc	tnbc	ADV
bptjm-57	80	37	)	)	PUNCT
bptjm-57	80	38	.	.	PUNCT
bptjm-57	81	1	knowing	know	VERB
bptjm-57	81	2	the	the	DET
bptjm-57	81	3	di	di	PROPN
bptjm-57	81	4	�	�	PROPN
bptjm-57	81	5	erent	erent	NOUN
bptjm-57	81	6	types	type	NOUN
bptjm-57	81	7	of	of	ADP
bptjm-57	81	8	cells	cell	NOUN
bptjm-57	81	9	in	in	ADP
bptjm-57	81	10	a	a	DET
bptjm-57	81	11	tumor	tumor	NOUN
bptjm-57	81	12	will	will	AUX
bptjm-57	81	13	become	become	VERB
bptjm-57	81	14	essential	essential	ADJ
bptjm-57	81	15	in	in	ADP
bptjm-57	81	16	the	the	DET
bptjm-57	81	17	personalized	personalized	ADJ
bptjm-57	81	18	treatment	treatment	NOUN
bptjm-57	81	19	for	for	ADP
bptjm-57	81	20	high	high	ADJ
bptjm-57	81	21	-	-	PUNCT
bptjm-57	81	22	degree	degree	NOUN
bptjm-57	81	23	heterogeneous	heterogeneous	ADJ
bptjm-57	81	24	tumors	tumor	NOUN
bptjm-57	81	25	,	,	PUNCT
bptjm-57	81	26	which	which	PRON
bptjm-57	81	27	will	will	AUX
bptjm-57	81	28	need	need	VERB
bptjm-57	81	29	a	a	DET
bptjm-57	81	30	combination	combination	NOUN
bptjm-57	81	31	of	of	ADP
bptjm-57	81	32	therapies	therapy	NOUN
bptjm-57	81	33	in	in	ADP
bptjm-57	81	34	order	order	NOUN
bptjm-57	81	35	to	to	PART
bptjm-57	81	36	be	be	AUX
bptjm-57	81	37	e	e	AUX
bptjm-57	81	38	�	�	NOUN
bptjm-57	81	39	ectively	ectively	ADV
bptjm-57	81	40	treated	treat	VERB
bptjm-57	81	41	.	.	PUNCT
bptjm-57	82	1	there	there	PRON
bptjm-57	82	2	are	be	VERB
bptjm-57	82	3	,	,	PUNCT
bptjm-57	82	4	however	however	ADV
bptjm-57	82	5	,	,	PUNCT
bptjm-57	82	6	some	some	DET
bptjm-57	82	7	limitations	limitation	NOUN
bptjm-57	82	8	to	to	ADP
bptjm-57	82	9	this	this	DET
bptjm-57	82	10	technology	technology	NOUN
bptjm-57	82	11	,	,	PUNCT
bptjm-57	82	12	including	include	VERB
bptjm-57	82	13	cell	cell	NOUN
bptjm-57	82	14	integrity	integrity	NOUN
bptjm-57	82	15	and	and	CCONJ
bptjm-57	82	16	viability	viability	NOUN
bptjm-57	82	17	,	,	PUNCT
bptjm-57	82	18	its	its	PRON
bptjm-57	82	19	relatively	relatively	ADV
bptjm-57	82	20	high	high	ADJ
bptjm-57	82	21	cost	cost	NOUN
bptjm-57	82	22	,	,	PUNCT
bptjm-57	82	23	and	and	CCONJ
bptjm-57	82	24	its	its	PRON
bptjm-57	82	25	integration	integration	NOUN
bptjm-57	82	26	with	with	ADP
bptjm-57	82	27	other	other	ADJ
bptjm-57	82	28	genomic	genomic	NOUN
bptjm-57	82	29	and	and	CCONJ
bptjm-57	82	30	protein	protein	NOUN
bptjm-57	82	31	information	information	NOUN
bptjm-57	82	32	.	.	PUNCT
bptjm-57	83	1	further	further	ADJ
bptjm-57	83	2	research	research	NOUN
bptjm-57	83	3	to	to	PART
bptjm-57	83	4	advance	advance	VERB
bptjm-57	83	5	scienti	scienti	NOUN
bptjm-57	83	6	�	�	NOUN
bptjm-57	83	7	c	c	NOUN
bptjm-57	83	8	and	and	CCONJ
bptjm-57	83	9	technological	technological	ADJ
bptjm-57	83	10	developments	development	NOUN
bptjm-57	83	11	,	,	PUNCT
bptjm-57	83	12	such	such	ADJ
bptjm-57	83	13	as	as	ADP
bptjm-57	83	14	gentle	gentle	ADJ
bptjm-57	83	15	extraction	extraction	NOUN
bptjm-57	83	16	and	and	CCONJ
bptjm-57	83	17	data	datum	NOUN
bptjm-57	83	18	analysis	analysis	NOUN
bptjm-57	83	19	methods	method	NOUN
bptjm-57	83	20	,	,	PUNCT
bptjm-57	83	21	is	be	AUX
bptjm-57	83	22	expected	expect	VERB
bptjm-57	83	23	to	to	PART
bptjm-57	83	24	overcome	overcome	VERB
bptjm-57	83	25	these	these	DET
bptjm-57	83	26	challenges.46	challenges.46	NOUN
bptjm-57	83	27	2.4	2.4	NUM
bptjm-57	83	28	complications	complication	NOUN
bptjm-57	83	29	of	of	ADP
bptjm-57	83	30	tumor	tumor	PROPN
bptjm-57	83	31	heterogeneity	heterogeneity	PROPN
bptjm-57	83	32	di	di	PROPN
bptjm-57	83	33	�	�	PROPN
bptjm-57	83	34	erent	erent	NOUN
bptjm-57	83	35	cell	cell	NOUN
bptjm-57	83	36	types	type	NOUN
bptjm-57	83	37	respond	respond	VERB
bptjm-57	83	38	to	to	ADP
bptjm-57	83	39	di	di	NOUN
bptjm-57	83	40	�	�	PROPN
bptjm-57	83	41	erent	erent	NOUN
bptjm-57	83	42	treatments	treatment	NOUN
bptjm-57	83	43	,	,	PUNCT
bptjm-57	83	44	which	which	PRON
bptjm-57	83	45	is	be	AUX
bptjm-57	83	46	the	the	DET
bptjm-57	83	47	reason	reason	NOUN
bptjm-57	83	48	behind	behind	ADP
bptjm-57	83	49	the	the	DET
bptjm-57	83	50	utilization	utilization	NOUN
bptjm-57	83	51	of	of	ADP
bptjm-57	83	52	combination	combination	NOUN
bptjm-57	83	53	therapies	therapy	NOUN
bptjm-57	83	54	for	for	ADP
bptjm-57	83	55	tumors	tumor	NOUN
bptjm-57	83	56	with	with	ADP
bptjm-57	83	57	high	high	ADJ
bptjm-57	83	58	degrees	degree	NOUN
bptjm-57	83	59	of	of	ADP
bptjm-57	83	60	heterogeneity	heterogeneity	NOUN
bptjm-57	83	61	.	.	PUNCT
bptjm-57	84	1	using	use	VERB
bptjm-57	84	2	a	a	DET
bptjm-57	84	3	single	single	ADJ
bptjm-57	84	4	treatment	treatment	NOUN
bptjm-57	84	5	can	can	AUX
bptjm-57	84	6	lead	lead	VERB
bptjm-57	84	7	to	to	ADP
bptjm-57	84	8	a	a	DET
bptjm-57	84	9	relapse	relapse	NOUN
bptjm-57	84	10	of	of	ADP
bptjm-57	84	11	cells	cell	NOUN
bptjm-57	84	12	that	that	PRON
bptjm-57	84	13	are	be	AUX
bptjm-57	84	14	more	more	ADV
bptjm-57	84	15	resistant	resistant	ADJ
bptjm-57	84	16	to	to	ADP
bptjm-57	84	17	typical	typical	ADJ
bptjm-57	84	18	therapies	therapy	NOUN
bptjm-57	84	19	.	.	PUNCT
bptjm-57	85	1	the	the	DET
bptjm-57	85	2	�	�	PROPN
bptjm-57	85	3	rst	rst	PROPN
bptjm-57	85	4	round	round	NOUN
bptjm-57	85	5	of	of	ADP
bptjm-57	85	6	treatment	treatment	NOUN
bptjm-57	85	7	might	might	AUX
bptjm-57	85	8	e	e	AUX
bptjm-57	85	9	�	�	NOUN
bptjm-57	85	10	ectively	ectively	ADV
bptjm-57	85	11	eliminate	eliminate	VERB
bptjm-57	85	12	one	one	NUM
bptjm-57	85	13	type	type	NOUN
bptjm-57	85	14	of	of	ADP
bptjm-57	85	15	cell	cell	NOUN
bptjm-57	85	16	,	,	PUNCT
bptjm-57	85	17	making	make	VERB
bptjm-57	85	18	the	the	DET
bptjm-57	85	19	tumor	tumor	NOUN
bptjm-57	85	20	appear	appear	VERB
bptjm-57	85	21	smaller	small	ADJ
bptjm-57	85	22	.	.	PUNCT
bptjm-57	86	1	however	however	ADV
bptjm-57	86	2	,	,	PUNCT
bptjm-57	86	3	over	over	ADP
bptjm-57	86	4	time	time	NOUN
bptjm-57	86	5	,	,	PUNCT
bptjm-57	86	6	the	the	DET
bptjm-57	86	7	cells	cell	NOUN
bptjm-57	86	8	that	that	PRON
bptjm-57	86	9	were	be	AUX
bptjm-57	86	10	unresponsive	unresponsive	ADJ
bptjm-57	86	11	to	to	ADP
bptjm-57	86	12	the	the	DET
bptjm-57	86	13	treatment	treatment	NOUN
bptjm-57	86	14	will	will	AUX
bptjm-57	86	15	become	become	VERB
bptjm-57	86	16	the	the	DET
bptjm-57	86	17	dominant	dominant	ADJ
bptjm-57	86	18	cell	cell	NOUN
bptjm-57	86	19	type	type	NOUN
bptjm-57	86	20	,	,	PUNCT
bptjm-57	86	21	which	which	PRON
bptjm-57	86	22	makes	make	VERB
bptjm-57	86	23	the	the	DET
bptjm-57	86	24	tumor	tumor	NOUN
bptjm-57	86	25	drug	drug	NOUN
bptjm-57	86	26	-	-	PUNCT
bptjm-57	86	27	resistant	resistant	ADJ
bptjm-57	86	28	and	and	CCONJ
bptjm-57	86	29	more	more	ADV
bptjm-57	86	30	challenging	challenging	ADJ
bptjm-57	86	31	to	to	PART
bptjm-57	86	32	treat	treat	VERB
bptjm-57	86	33	further	far	ADV
bptjm-57	86	34	.	.	PUNCT
bptjm-57	87	1	the	the	DET
bptjm-57	87	2	term	term	NOUN
bptjm-57	87	3	for	for	ADP
bptjm-57	87	4	this	this	DET
bptjm-57	87	5	phenomenon	phenomenon	NOUN
bptjm-57	87	6	is	be	AUX
bptjm-57	87	7	called	call	VERB
bptjm-57	87	8	selective	selective	ADJ
bptjm-57	87	9	pressure.10	pressure.10	NOUN
bptjm-57	87	10	a	a	DET
bptjm-57	87	11	study	study	NOUN
bptjm-57	87	12	observed	observe	VERB
bptjm-57	87	13	20	20	NUM
bptjm-57	87	14	patients	patient	NOUN
bptjm-57	87	15	with	with	ADP
bptjm-57	87	16	tnbc	tnbc	PROPN
bptjm-57	87	17	treated	treat	VERB
bptjm-57	87	18	with	with	ADP
bptjm-57	87	19	neoadjuvant	neoadjuvant	ADJ
bptjm-57	87	20	chemotherapy	chemotherapy	NOUN
bptjm-57	87	21	(	(	PUNCT
bptjm-57	87	22	nac	nac	PROPN
bptjm-57	87	23	)	)	PUNCT
bptjm-57	87	24	to	to	PART
bptjm-57	87	25	combat	combat	VERB
bptjm-57	87	26	highly	highly	ADV
bptjm-57	87	27	heterogeneous	heterogeneous	ADJ
bptjm-57	87	28	cells	cell	NOUN
bptjm-57	87	29	,	,	PUNCT
bptjm-57	87	30	a	a	DET
bptjm-57	87	31	characteristic	characteristic	NOUN
bptjm-57	87	32	of	of	ADP
bptjm-57	87	33	tnbc	tnbc	ADV
bptjm-57	87	34	.	.	PUNCT
bptjm-57	88	1	they	they	PRON
bptjm-57	88	2	determined	determine	VERB
bptjm-57	88	3	that	that	SCONJ
bptjm-57	88	4	this	this	DET
bptjm-57	88	5	type	type	NOUN
bptjm-57	88	6	of	of	ADP
bptjm-57	88	7	resistance	resistance	NOUN
bptjm-57	88	8	can	can	AUX
bptjm-57	88	9	be	be	AUX
bptjm-57	88	10	acquired	acquire	VERB
bptjm-57	88	11	and	and	CCONJ
bptjm-57	88	12	adapted	adapt	VERB
bptjm-57	88	13	.	.	PUNCT
bptjm-57	89	1	additionally	additionally	ADV
bptjm-57	89	2	,	,	PUNCT
bptjm-57	89	3	they	they	PRON
bptjm-57	89	4	found	find	VERB
bptjm-57	89	5	evidence	evidence	NOUN
bptjm-57	89	6	that	that	SCONJ
bptjm-57	89	7	the	the	DET
bptjm-57	89	8	patients	patient	NOUN
bptjm-57	89	9	who	who	PRON
bptjm-57	89	10	experienced	experience	VERB
bptjm-57	89	11	relapses	relapse	NOUN
bptjm-57	89	12	,	,	PUNCT
bptjm-57	89	13	as	as	SCONJ
bptjm-57	89	14	opposed	oppose	VERB
bptjm-57	89	15	to	to	ADP
bptjm-57	89	16	cancer	cancer	NOUN
bptjm-57	89	17	elimination	elimination	NOUN
bptjm-57	89	18	,	,	PUNCT
bptjm-57	89	19	had	have	AUX
bptjm-57	89	20	cells	cell	NOUN
bptjm-57	89	21	with	with	ADP
bptjm-57	89	22	genetic	genetic	ADJ
bptjm-57	89	23	markers	marker	NOUN
bptjm-57	89	24	for	for	ADP
bptjm-57	89	25	that	that	DET
bptjm-57	89	26	chemoresistance	chemoresistance	NOUN
bptjm-57	89	27	.	.	PUNCT
bptjm-57	90	1	the	the	DET
bptjm-57	90	2	researchers	researcher	NOUN
bptjm-57	90	3	were	be	AUX
bptjm-57	90	4	able	able	ADJ
bptjm-57	90	5	to	to	PART
bptjm-57	90	6	determine	determine	VERB
bptjm-57	90	7	potential	potential	ADJ
bptjm-57	90	8	treatments	treatment	NOUN
bptjm-57	90	9	for	for	ADP
bptjm-57	90	10	the	the	DET
bptjm-57	90	11	cells	cell	NOUN
bptjm-57	90	12	that	that	PRON
bptjm-57	90	13	had	have	VERB
bptjm-57	90	14	genetic	genetic	ADJ
bptjm-57	90	15	resistance	resistance	NOUN
bptjm-57	90	16	using	use	VERB
bptjm-57	90	17	single	single	ADJ
bptjm-57	90	18	-	-	PUNCT
bptjm-57	90	19	cell	cell	NOUN
bptjm-57	90	20	rna	rna	NOUN
bptjm-57	90	21	and	and	CCONJ
bptjm-57	90	22	dna	dna	NOUN
bptjm-57	90	23	sequencing	sequencing	NOUN
bptjm-57	90	24	.	.	PUNCT
bptjm-57	91	1	these	these	DET
bptjm-57	91	2	treatments	treatment	NOUN
bptjm-57	91	3	included	include	VERB
bptjm-57	91	4	emt	emt	PROPN
bptjm-57	91	5	signaling	signaling	NOUN
bptjm-57	91	6	,	,	PUNCT
bptjm-57	91	7	p13k	p13k	NOUN
bptjm-57	91	8	inhibitors	inhibitor	NOUN
bptjm-57	91	9	,	,	PUNCT
bptjm-57	91	10	and	and	CCONJ
bptjm-57	91	11	hypoxia	hypoxia	NOUN
bptjm-57	91	12	inhibition	inhibition	NOUN
bptjm-57	91	13	using	use	VERB
bptjm-57	91	14	hif-1	hif-1	PUNCT
bptjm-57	91	15	inhibitors.47	inhibitors.47	NOUN
bptjm-57	91	16	,	,	PUNCT
bptjm-57	91	17	48	48	NUM
bptjm-57	91	18	berkeley	berkeley	PROPN
bptjm-57	91	19	pharma	pharma	PROPN
bptjm-57	91	20	tech	tech	NOUN
bptjm-57	91	21	journal	journal	NOUN
bptjm-57	91	22	of	of	ADP
bptjm-57	91	23	medicine	medicine	NOUN
bptjm-57	91	24	|	|	ADV
bptjm-57	91	25	93	93	NUM
bptjm-57	91	26	another	another	DET
bptjm-57	91	27	study	study	NOUN
bptjm-57	91	28	investigated	investigate	VERB
bptjm-57	91	29	the	the	DET
bptjm-57	91	30	role	role	NOUN
bptjm-57	91	31	of	of	ADP
bptjm-57	91	32	tumor	tumor	NOUN
bptjm-57	91	33	heterogeneity	heterogeneity	NOUN
bptjm-57	91	34	in	in	ADP
bptjm-57	91	35	the	the	DET
bptjm-57	91	36	resistance	resistance	NOUN
bptjm-57	91	37	to	to	ADP
bptjm-57	91	38	egfr	egfr	ADV
bptjm-57	91	39	-	-	PUNCT
bptjm-57	91	40	targeted	target	VERB
bptjm-57	91	41	treatment	treatment	NOUN
bptjm-57	91	42	in	in	ADP
bptjm-57	91	43	colorectal	colorectal	ADJ
bptjm-57	91	44	cancer	cancer	NOUN
bptjm-57	91	45	cells	cell	NOUN
bptjm-57	91	46	.	.	PUNCT
bptjm-57	92	1	three	three	NUM
bptjm-57	92	2	cetuximab	cetuximab	NOUN
bptjm-57	92	3	-	-	PUNCT
bptjm-57	92	4	resistant	resistant	ADJ
bptjm-57	92	5	derivatives	derivative	NOUN
bptjm-57	92	6	of	of	ADP
bptjm-57	92	7	lim1215	lim1215	NOUN
bptjm-57	92	8	,	,	PUNCT
bptjm-57	92	9	oxco-2	oxco-2	NUM
bptjm-57	92	10	,	,	PUNCT
bptjm-57	92	11	and	and	CCONJ
bptjm-57	92	12	difi	difi	NOUN
bptjm-57	92	13	cell	cell	NOUN
bptjm-57	92	14	lineages	lineage	NOUN
bptjm-57	92	15	were	be	AUX
bptjm-57	92	16	utilized	utilize	VERB
bptjm-57	92	17	in	in	ADP
bptjm-57	92	18	next	next	ADJ
bptjm-57	92	19	-	-	PUNCT
bptjm-57	92	20	generation	generation	NOUN
bptjm-57	92	21	sequencing	sequencing	NOUN
bptjm-57	92	22	,	,	PUNCT
bptjm-57	92	23	immunohistochemistry	immunohistochemistry	NOUN
bptjm-57	92	24	,	,	PUNCT
bptjm-57	92	25	and	and	CCONJ
bptjm-57	92	26	proliferation	proliferation	NOUN
bptjm-57	92	27	assays	assay	NOUN
bptjm-57	92	28	to	to	PART
bptjm-57	92	29	identify	identify	VERB
bptjm-57	92	30	the	the	DET
bptjm-57	92	31	mechanisms	mechanism	NOUN
bptjm-57	92	32	of	of	ADP
bptjm-57	92	33	drug	drug	NOUN
bptjm-57	92	34	resistance	resistance	NOUN
bptjm-57	92	35	in	in	ADP
bptjm-57	92	36	tumor	tumor	NOUN
bptjm-57	92	37	cells	cell	NOUN
bptjm-57	92	38	.	.	PUNCT
bptjm-57	93	1	the	the	DET
bptjm-57	93	2	results	result	NOUN
bptjm-57	93	3	in	in	ADP
bptjm-57	93	4	the	the	DET
bptjm-57	93	5	cell	cell	NOUN
bptjm-57	93	6	proliferation	proliferation	NOUN
bptjm-57	93	7	assays	assay	NOUN
bptjm-57	93	8	showed	show	VERB
bptjm-57	93	9	that	that	SCONJ
bptjm-57	93	10	colorectal	colorectal	ADJ
bptjm-57	93	11	cancer	cancer	NOUN
bptjm-57	93	12	cells	cell	NOUN
bptjm-57	93	13	with	with	ADP
bptjm-57	93	14	developed	developed	ADJ
bptjm-57	93	15	resistance	resistance	NOUN
bptjm-57	93	16	to	to	ADP
bptjm-57	93	17	cetuximab	cetuximab	NOUN
bptjm-57	93	18	and	and	CCONJ
bptjm-57	93	19	panitumumab	panitumumab	NOUN
bptjm-57	93	20	secrete	secrete	NOUN
bptjm-57	93	21	transforming	transform	VERB
bptjm-57	93	22	growth	growth	NOUN
bptjm-57	93	23	factor	factor	NOUN
bptjm-57	93	24	alpha	alpha	NOUN
bptjm-57	93	25	(	(	PUNCT
bptjm-57	93	26	tgf	tgf	PROPN
bptjm-57	93	27	-	-	PUNCT
bptjm-57	93	28	α	α	NOUN
bptjm-57	93	29	)	)	PUNCT
bptjm-57	93	30	and	and	CCONJ
bptjm-57	93	31	amphiregulin	amphiregulin	NOUN
bptjm-57	93	32	.	.	PUNCT
bptjm-57	94	1	these	these	DET
bptjm-57	94	2	secreted	secrete	VERB
bptjm-57	94	3	growth	growth	NOUN
bptjm-57	94	4	factors	factor	NOUN
bptjm-57	94	5	protect	protect	VERB
bptjm-57	94	6	the	the	DET
bptjm-57	94	7	encompassing	encompass	VERB
bptjm-57	94	8	sensitive	sensitive	ADJ
bptjm-57	94	9	cells	cell	NOUN
bptjm-57	94	10	from	from	ADP
bptjm-57	94	11	egfr	egfr	ADJ
bptjm-57	94	12	blockade	blockade	NOUN
bptjm-57	94	13	by	by	ADP
bptjm-57	94	14	sustaining	sustain	VERB
bptjm-57	94	15	egfr	egfr	PROPN
bptjm-57	94	16	/	/	SYM
bptjm-57	94	17	erk	erk	NOUN
bptjm-57	94	18	signaling	signal	VERB
bptjm-57	94	19	in	in	ADP
bptjm-57	94	20	sensitive	sensitive	ADJ
bptjm-57	94	21	cells	cell	NOUN
bptjm-57	94	22	.	.	PUNCT
bptjm-57	95	1	the	the	DET
bptjm-57	95	2	results	result	NOUN
bptjm-57	95	3	showed	show	VERB
bptjm-57	95	4	that	that	SCONJ
bptjm-57	95	5	tgf	tgf	PROPN
bptjm-57	95	6	-	-	PUNCT
bptjm-57	95	7	α	α	PROPN
bptjm-57	95	8	and	and	CCONJ
bptjm-57	95	9	amphiregulin	amphiregulin	NOUN
bptjm-57	95	10	binding	bind	VERB
bptjm-57	95	11	to	to	ADP
bptjm-57	95	12	egfr	egfr	PROPN
bptjm-57	95	13	caused	cause	VERB
bptjm-57	95	14	a	a	DET
bptjm-57	95	15	longer	long	ADJ
bptjm-57	95	16	retention	retention	NOUN
bptjm-57	95	17	time	time	NOUN
bptjm-57	95	18	of	of	ADP
bptjm-57	95	19	the	the	DET
bptjm-57	95	20	receptor	receptor	NOUN
bptjm-57	95	21	on	on	ADP
bptjm-57	95	22	the	the	DET
bptjm-57	95	23	surface	surface	NOUN
bptjm-57	95	24	of	of	ADP
bptjm-57	95	25	the	the	DET
bptjm-57	95	26	plasma	plasma	NOUN
bptjm-57	95	27	membrane	membrane	NOUN
bptjm-57	95	28	and	and	CCONJ
bptjm-57	95	29	redirected	redirect	VERB
bptjm-57	95	30	egfr	egfr	NOUN
bptjm-57	95	31	to	to	ADP
bptjm-57	95	32	the	the	DET
bptjm-57	95	33	recycling	recycling	NOUN
bptjm-57	95	34	pathway	pathway	NOUN
bptjm-57	95	35	rather	rather	ADV
bptjm-57	95	36	than	than	ADP
bptjm-57	95	37	to	to	PART
bptjm-57	95	38	proteasomal	proteasomal	VERB
bptjm-57	95	39	degradation	degradation	NOUN
bptjm-57	95	40	.	.	PUNCT
bptjm-57	96	1	this	this	PRON
bptjm-57	96	2	can	can	AUX
bptjm-57	96	3	potentially	potentially	ADV
bptjm-57	96	4	enhance	enhance	VERB
bptjm-57	96	5	the	the	DET
bptjm-57	96	6	pro	pro	ADJ
bptjm-57	96	7	-	-	ADJ
bptjm-57	96	8	proliferating	proliferating	ADJ
bptjm-57	96	9	e	e	NOUN
bptjm-57	96	10	�	�	NOUN
bptjm-57	96	11	ect	ect	NOUN
bptjm-57	96	12	of	of	ADP
bptjm-57	96	13	the	the	DET
bptjm-57	96	14	protective	protective	ADJ
bptjm-57	96	15	microenvironment.49	microenvironment.49	NOUN
bptjm-57	96	16	3	3	NUM
bptjm-57	96	17	.	.	PUNCT
bptjm-57	97	1	treatments	treatment	NOUN
bptjm-57	97	2	of	of	ADP
bptjm-57	97	3	interest	interest	NOUN
bptjm-57	97	4	3.1	3.1	NUM
bptjm-57	97	5	immunotherapy	immunotherapy	NOUN
bptjm-57	97	6	cancer	cancer	NOUN
bptjm-57	97	7	immunotherapy	immunotherapy	NOUN
bptjm-57	97	8	utilizes	utilize	VERB
bptjm-57	97	9	the	the	DET
bptjm-57	97	10	body	body	NOUN
bptjm-57	97	11	’s	’s	PART
bptjm-57	97	12	immune	immune	ADJ
bptjm-57	97	13	system	system	NOUN
bptjm-57	97	14	against	against	ADP
bptjm-57	97	15	cancer	cancer	NOUN
bptjm-57	97	16	.	.	PUNCT
bptjm-57	98	1	some	some	DET
bptjm-57	98	2	patients	patient	NOUN
bptjm-57	98	3	possess	possess	VERB
bptjm-57	98	4	immune	immune	ADJ
bptjm-57	98	5	system	system	NOUN
bptjm-57	98	6	components	component	NOUN
bptjm-57	98	7	that	that	PRON
bptjm-57	98	8	naturally	naturally	ADV
bptjm-57	98	9	�	�	VERB
bptjm-57	98	10	ght	ght	PROPN
bptjm-57	98	11	the	the	DET
bptjm-57	98	12	cancer	cancer	NOUN
bptjm-57	98	13	cells	cell	NOUN
bptjm-57	98	14	,	,	PUNCT
bptjm-57	98	15	called	call	VERB
bptjm-57	98	16	tumor	tumor	NOUN
bptjm-57	98	17	-	-	PUNCT
bptjm-57	98	18	in	in	ADP
bptjm-57	98	19	�	�	NOUN
bptjm-57	98	20	ltrating	ltrating	NOUN
bptjm-57	98	21	lymphocytes	lymphocyte	NOUN
bptjm-57	98	22	(	(	PUNCT
bptjm-57	98	23	tils	til	NOUN
bptjm-57	98	24	)	)	PUNCT
bptjm-57	98	25	,	,	PUNCT
bptjm-57	98	26	while	while	SCONJ
bptjm-57	98	27	others	other	NOUN
bptjm-57	98	28	do	do	VERB
bptjm-57	98	29	not	not	PART
bptjm-57	98	30	.	.	PUNCT
bptjm-57	99	1	despite	despite	SCONJ
bptjm-57	99	2	a	a	DET
bptjm-57	99	3	patient	patient	ADJ
bptjm-57	99	4	possessing	possessing	NOUN
bptjm-57	99	5	tils	til	NOUN
bptjm-57	99	6	,	,	PUNCT
bptjm-57	99	7	the	the	DET
bptjm-57	99	8	immune	immune	ADJ
bptjm-57	99	9	system	system	NOUN
bptjm-57	99	10	still	still	ADV
bptjm-57	99	11	has	have	VERB
bptjm-57	99	12	di	di	PROPN
bptjm-57	99	13	�	�	PROPN
bptjm-57	99	14	culty	culty	PROPN
bptjm-57	99	15	�	�	PROPN
bptjm-57	99	16	ghting	ghte	VERB
bptjm-57	99	17	the	the	DET
bptjm-57	99	18	cancer	cancer	NOUN
bptjm-57	99	19	cells	cell	NOUN
bptjm-57	99	20	since	since	SCONJ
bptjm-57	99	21	they	they	PRON
bptjm-57	99	22	are	be	AUX
bptjm-57	99	23	,	,	PUNCT
bptjm-57	99	24	by	by	ADP
bptjm-57	99	25	de	de	PROPN
bptjm-57	99	26	�	�	PROPN
bptjm-57	99	27	nition	nition	NOUN
bptjm-57	99	28	,	,	PUNCT
bptjm-57	99	29	abnormal	abnormal	ADJ
bptjm-57	99	30	and	and	CCONJ
bptjm-57	99	31	lack	lack	VERB
bptjm-57	99	32	certain	certain	ADJ
bptjm-57	99	33	processes	process	NOUN
bptjm-57	99	34	that	that	PRON
bptjm-57	99	35	normal	normal	ADJ
bptjm-57	99	36	cells	cell	NOUN
bptjm-57	99	37	should	should	AUX
bptjm-57	99	38	have	have	VERB
bptjm-57	99	39	,	,	PUNCT
bptjm-57	99	40	such	such	ADJ
bptjm-57	99	41	as	as	ADP
bptjm-57	99	42	missing	miss	VERB
bptjm-57	99	43	proteins.49	proteins.49	NOUN
bptjm-57	99	44	immunotherapy	immunotherapy	NOUN
bptjm-57	99	45	includes	include	VERB
bptjm-57	99	46	various	various	ADJ
bptjm-57	99	47	treatment	treatment	NOUN
bptjm-57	99	48	options	option	NOUN
bptjm-57	99	49	,	,	PUNCT
bptjm-57	99	50	including	include	VERB
bptjm-57	99	51	immune	immune	ADJ
bptjm-57	99	52	checkpoint	checkpoint	NOUN
bptjm-57	99	53	inhibitors	inhibitor	NOUN
bptjm-57	99	54	,	,	PUNCT
bptjm-57	99	55	adoptive	adoptive	ADJ
bptjm-57	99	56	cellular	cellular	ADJ
bptjm-57	99	57	therapy	therapy	NOUN
bptjm-57	99	58	(	(	PUNCT
bptjm-57	99	59	act	act	PROPN
bptjm-57	99	60	)	)	PUNCT
bptjm-57	99	61	,	,	PUNCT
bptjm-57	99	62	monoclonal	monoclonal	NOUN
bptjm-57	99	63	antibodies	antibody	NOUN
bptjm-57	99	64	,	,	PUNCT
bptjm-57	99	65	treatment	treatment	NOUN
bptjm-57	99	66	vaccines	vaccine	NOUN
bptjm-57	99	67	,	,	PUNCT
bptjm-57	99	68	and	and	CCONJ
bptjm-57	99	69	immune	immune	ADJ
bptjm-57	99	70	system	system	NOUN
bptjm-57	99	71	modulators.50,51	modulators.50,51	NOUN
bptjm-57	99	72	one	one	NUM
bptjm-57	99	73	type	type	NOUN
bptjm-57	99	74	of	of	ADP
bptjm-57	99	75	immunotherapy	immunotherapy	NOUN
bptjm-57	99	76	that	that	PRON
bptjm-57	99	77	has	have	AUX
bptjm-57	99	78	shown	show	VERB
bptjm-57	99	79	great	great	ADJ
bptjm-57	99	80	promise	promise	NOUN
bptjm-57	99	81	in	in	ADP
bptjm-57	99	82	recent	recent	ADJ
bptjm-57	99	83	years	year	NOUN
bptjm-57	99	84	is	be	AUX
bptjm-57	99	85	chimeric	chimeric	ADJ
bptjm-57	99	86	antigen	antigen	ADJ
bptjm-57	99	87	receptor	receptor	NOUN
bptjm-57	99	88	(	(	PUNCT
bptjm-57	99	89	car)-t	car)-t	NOUN
bptjm-57	99	90	cell	cell	NOUN
bptjm-57	99	91	therapy	therapy	NOUN
bptjm-57	99	92	,	,	PUNCT
bptjm-57	99	93	a	a	DET
bptjm-57	99	94	type	type	NOUN
bptjm-57	99	95	of	of	ADP
bptjm-57	99	96	act	act	NOUN
bptjm-57	99	97	.	.	PUNCT
bptjm-57	100	1	unfortunately	unfortunately	ADV
bptjm-57	100	2	,	,	PUNCT
bptjm-57	100	3	it	it	PRON
bptjm-57	100	4	is	be	AUX
bptjm-57	100	5	only	only	ADV
bptjm-57	100	6	approved	approve	VERB
bptjm-57	100	7	for	for	ADP
bptjm-57	100	8	the	the	DET
bptjm-57	100	9	treatment	treatment	NOUN
bptjm-57	100	10	of	of	ADP
bptjm-57	100	11	blood	blood	NOUN
bptjm-57	100	12	cancers	cancer	NOUN
bptjm-57	100	13	,	,	PUNCT
bptjm-57	100	14	and	and	CCONJ
bptjm-57	100	15	research	research	NOUN
bptjm-57	100	16	into	into	ADP
bptjm-57	100	17	its	its	PRON
bptjm-57	100	18	e	e	NOUN
bptjm-57	100	19	�	�	NOUN
bptjm-57	100	20	ects	ect	VERB
bptjm-57	100	21	on	on	ADP
bptjm-57	100	22	solid	solid	ADJ
bptjm-57	100	23	tumors	tumor	NOUN
bptjm-57	100	24	is	be	AUX
bptjm-57	100	25	ongoing	ongoing	ADJ
bptjm-57	100	26	.	.	PUNCT
bptjm-57	101	1	car	car	NOUN
bptjm-57	101	2	-	-	PUNCT
bptjm-57	101	3	t	t	NOUN
bptjm-57	101	4	cell	cell	NOUN
bptjm-57	101	5	therapy	therapy	NOUN
bptjm-57	101	6	uses	use	VERB
bptjm-57	101	7	either	either	CCONJ
bptjm-57	101	8	analogous	analogous	ADJ
bptjm-57	101	9	or	or	CCONJ
bptjm-57	101	10	allogeneic	allogeneic	ADJ
bptjm-57	101	11	donated	donate	VERB
bptjm-57	101	12	t	t	PROPN
bptjm-57	101	13	cells	cell	NOUN
bptjm-57	101	14	that	that	PRON
bptjm-57	101	15	can	can	AUX
bptjm-57	101	16	be	be	AUX
bptjm-57	101	17	found	find	VERB
bptjm-57	101	18	as	as	ADP
bptjm-57	101	19	part	part	NOUN
bptjm-57	101	20	of	of	ADP
bptjm-57	101	21	the	the	DET
bptjm-57	101	22	immune	immune	ADJ
bptjm-57	101	23	system	system	NOUN
bptjm-57	101	24	.	.	PUNCT
bptjm-57	102	1	these	these	DET
bptjm-57	102	2	cells	cell	NOUN
bptjm-57	102	3	are	be	AUX
bptjm-57	102	4	then	then	ADV
bptjm-57	102	5	genetically	genetically	ADV
bptjm-57	102	6	modi	modi	PROPN
bptjm-57	102	7	�	�	PROPN
bptjm-57	102	8	ed	ed	PROPN
bptjm-57	102	9	to	to	PART
bptjm-57	102	10	express	express	VERB
bptjm-57	102	11	berkeley	berkeley	PROPN
bptjm-57	102	12	pharma	pharma	PROPN
bptjm-57	102	13	tech	tech	NOUN
bptjm-57	102	14	journal	journal	NOUN
bptjm-57	102	15	of	of	ADP
bptjm-57	102	16	medicine	medicine	NOUN
bptjm-57	102	17	|	|	ADV
bptjm-57	102	18	94	94	NUM
bptjm-57	102	19	cars	car	NOUN
bptjm-57	102	20	that	that	PRON
bptjm-57	102	21	target	target	VERB
bptjm-57	102	22	a	a	DET
bptjm-57	102	23	speci	speci	ADJ
bptjm-57	102	24	�	�	PROPN
bptjm-57	102	25	c	c	PROPN
bptjm-57	102	26	antigen	antigen	NOUN
bptjm-57	102	27	found	find	VERB
bptjm-57	102	28	on	on	ADP
bptjm-57	102	29	the	the	DET
bptjm-57	102	30	surface	surface	NOUN
bptjm-57	102	31	of	of	ADP
bptjm-57	102	32	the	the	DET
bptjm-57	102	33	intended	intended	ADJ
bptjm-57	102	34	cancer	cancer	NOUN
bptjm-57	102	35	cells	cell	NOUN
bptjm-57	102	36	.	.	PUNCT
bptjm-57	103	1	this	this	DET
bptjm-57	103	2	therapy	therapy	NOUN
bptjm-57	103	3	is	be	AUX
bptjm-57	103	4	designed	design	VERB
bptjm-57	103	5	to	to	PART
bptjm-57	103	6	boost	boost	VERB
bptjm-57	103	7	the	the	DET
bptjm-57	103	8	immune	immune	ADJ
bptjm-57	103	9	system	system	NOUN
bptjm-57	103	10	and	and	CCONJ
bptjm-57	103	11	provide	provide	VERB
bptjm-57	103	12	a	a	DET
bptjm-57	103	13	speci	speci	ADJ
bptjm-57	103	14	�	�	PROPN
bptjm-57	103	15	c	c	PROPN
bptjm-57	103	16	target	target	NOUN
bptjm-57	103	17	.	.	PUNCT
bptjm-57	104	1	figure	figure	NOUN
bptjm-57	104	2	2	2	NUM
bptjm-57	104	3	summarizes	summarize	NOUN
bptjm-57	104	4	the	the	DET
bptjm-57	104	5	steps	step	NOUN
bptjm-57	104	6	of	of	ADP
bptjm-57	104	7	car	car	NOUN
bptjm-57	104	8	-	-	PUNCT
bptjm-57	104	9	t	t	NOUN
bptjm-57	104	10	cell	cell	NOUN
bptjm-57	104	11	therapy	therapy	NOUN
bptjm-57	104	12	.	.	PUNCT
bptjm-57	105	1	a	a	DET
bptjm-57	105	2	disadvantage	disadvantage	NOUN
bptjm-57	105	3	of	of	ADP
bptjm-57	105	4	this	this	DET
bptjm-57	105	5	therapy	therapy	NOUN
bptjm-57	105	6	is	be	AUX
bptjm-57	105	7	that	that	SCONJ
bptjm-57	105	8	it	it	PRON
bptjm-57	105	9	can	can	AUX
bptjm-57	105	10	lead	lead	VERB
bptjm-57	105	11	to	to	ADP
bptjm-57	105	12	selective	selective	ADJ
bptjm-57	105	13	pressure	pressure	NOUN
bptjm-57	105	14	since	since	SCONJ
bptjm-57	105	15	t	t	NOUN
bptjm-57	105	16	cells	cell	NOUN
bptjm-57	105	17	only	only	ADV
bptjm-57	105	18	target	target	VERB
bptjm-57	105	19	one	one	NUM
bptjm-57	105	20	antigen	antigen	NOUN
bptjm-57	105	21	at	at	ADP
bptjm-57	105	22	a	a	DET
bptjm-57	105	23	time	time	NOUN
bptjm-57	105	24	.	.	PUNCT
bptjm-57	106	1	selective	selective	ADJ
bptjm-57	106	2	pressure	pressure	NOUN
bptjm-57	106	3	refers	refer	VERB
bptjm-57	106	4	to	to	ADP
bptjm-57	106	5	the	the	DET
bptjm-57	106	6	eventual	eventual	ADJ
bptjm-57	106	7	resistance	resistance	NOUN
bptjm-57	106	8	of	of	ADP
bptjm-57	106	9	a	a	DET
bptjm-57	106	10	heterogeneous	heterogeneous	ADJ
bptjm-57	106	11	tumor	tumor	NOUN
bptjm-57	106	12	with	with	ADP
bptjm-57	106	13	multiple	multiple	ADJ
bptjm-57	106	14	antigens	antigen	NOUN
bptjm-57	106	15	to	to	ADP
bptjm-57	106	16	car	car	NOUN
bptjm-57	106	17	-	-	PUNCT
bptjm-57	106	18	t	t	NOUN
bptjm-57	106	19	cell	cell	NOUN
bptjm-57	106	20	therapy	therapy	NOUN
bptjm-57	106	21	.	.	PUNCT
bptjm-57	107	1	this	this	DET
bptjm-57	107	2	process	process	NOUN
bptjm-57	107	3	is	be	AUX
bptjm-57	107	4	due	due	ADJ
bptjm-57	107	5	to	to	ADP
bptjm-57	107	6	the	the	DET
bptjm-57	107	7	elimination	elimination	NOUN
bptjm-57	107	8	of	of	ADP
bptjm-57	107	9	all	all	PRON
bptjm-57	107	10	of	of	ADP
bptjm-57	107	11	the	the	DET
bptjm-57	107	12	cells	cell	NOUN
bptjm-57	107	13	within	within	ADP
bptjm-57	107	14	the	the	DET
bptjm-57	107	15	target	target	NOUN
bptjm-57	107	16	antigen	antigen	ADV
bptjm-57	107	17	,	,	PUNCT
bptjm-57	107	18	leaving	leave	VERB
bptjm-57	107	19	only	only	ADV
bptjm-57	107	20	the	the	DET
bptjm-57	107	21	cancer	cancer	NOUN
bptjm-57	107	22	cells	cell	NOUN
bptjm-57	107	23	that	that	PRON
bptjm-57	107	24	do	do	AUX
bptjm-57	107	25	not	not	PART
bptjm-57	107	26	have	have	VERB
bptjm-57	107	27	the	the	DET
bptjm-57	107	28	target	target	NOUN
bptjm-57	107	29	antigen	antigen	ADV
bptjm-57	107	30	and	and	CCONJ
bptjm-57	107	31	therefore	therefore	ADV
bptjm-57	107	32	do	do	AUX
bptjm-57	107	33	not	not	PART
bptjm-57	107	34	respond	respond	VERB
bptjm-57	107	35	to	to	ADP
bptjm-57	107	36	the	the	DET
bptjm-57	107	37	therapy.51elimination	therapy.51elimination	NUM
bptjm-57	107	38	of	of	ADP
bptjm-57	107	39	the	the	DET
bptjm-57	107	40	target	target	NOUN
bptjm-57	107	41	antigen	antigen	NOUN
bptjm-57	107	42	is	be	AUX
bptjm-57	107	43	also	also	ADV
bptjm-57	107	44	known	know	VERB
bptjm-57	107	45	as	as	ADP
bptjm-57	107	46	antigen	antigen	ADJ
bptjm-57	107	47	loss	loss	NOUN
bptjm-57	107	48	or	or	CCONJ
bptjm-57	107	49	escape	escape	NOUN
bptjm-57	107	50	.	.	PUNCT
bptjm-57	108	1	many	many	ADJ
bptjm-57	108	2	ongoing	ongoing	ADJ
bptjm-57	108	3	clinical	clinical	ADJ
bptjm-57	108	4	trials	trial	NOUN
bptjm-57	108	5	seek	seek	VERB
bptjm-57	108	6	to	to	PART
bptjm-57	108	7	determine	determine	VERB
bptjm-57	108	8	if	if	SCONJ
bptjm-57	108	9	car	car	NOUN
bptjm-57	108	10	-	-	PUNCT
bptjm-57	108	11	t	t	NOUN
bptjm-57	108	12	cells	cell	NOUN
bptjm-57	108	13	are	be	AUX
bptjm-57	108	14	e	e	ADJ
bptjm-57	108	15	�	�	NOUN
bptjm-57	108	16	ective	ective	ADJ
bptjm-57	108	17	treatments	treatment	NOUN
bptjm-57	108	18	for	for	ADP
bptjm-57	108	19	cancers	cancer	NOUN
bptjm-57	108	20	with	with	ADP
bptjm-57	108	21	solid	solid	ADJ
bptjm-57	108	22	tumors	tumor	NOUN
bptjm-57	108	23	,	,	PUNCT
bptjm-57	108	24	given	give	VERB
bptjm-57	108	25	that	that	SCONJ
bptjm-57	108	26	it	it	PRON
bptjm-57	108	27	is	be	AUX
bptjm-57	108	28	an	an	DET
bptjm-57	108	29	approved	approve	VERB
bptjm-57	108	30	treatment	treatment	NOUN
bptjm-57	108	31	for	for	ADP
bptjm-57	108	32	blood	blood	NOUN
bptjm-57	108	33	cancers	cancer	NOUN
bptjm-57	108	34	.	.	PUNCT
bptjm-57	109	1	trials	trial	NOUN
bptjm-57	109	2	,	,	PUNCT
bptjm-57	109	3	even	even	ADV
bptjm-57	109	4	those	those	PRON
bptjm-57	109	5	without	without	ADP
bptjm-57	109	6	reliable	reliable	ADJ
bptjm-57	109	7	results	result	NOUN
bptjm-57	109	8	,	,	PUNCT
bptjm-57	109	9	are	be	AUX
bptjm-57	109	10	relevant	relevant	ADJ
bptjm-57	109	11	to	to	ADP
bptjm-57	109	12	conversations	conversation	NOUN
bptjm-57	109	13	about	about	ADP
bptjm-57	109	14	treatments	treatment	NOUN
bptjm-57	109	15	of	of	ADP
bptjm-57	109	16	interest	interest	NOUN
bptjm-57	109	17	because	because	SCONJ
bptjm-57	109	18	it	it	PRON
bptjm-57	109	19	demonstrates	demonstrate	VERB
bptjm-57	109	20	the	the	DET
bptjm-57	109	21	researchers	researcher	NOUN
bptjm-57	109	22	’	’	PART
bptjm-57	109	23	belief	belief	NOUN
bptjm-57	109	24	that	that	SCONJ
bptjm-57	109	25	these	these	DET
bptjm-57	109	26	therapies	therapy	NOUN
bptjm-57	109	27	have	have	AUX
bptjm-57	109	28	great	great	ADJ
bptjm-57	109	29	potential	potential	NOUN
bptjm-57	109	30	to	to	PART
bptjm-57	109	31	be	be	AUX
bptjm-57	109	32	e	e	NOUN
bptjm-57	109	33	�	�	NOUN
bptjm-57	109	34	ective	ective	ADJ
bptjm-57	109	35	.	.	PUNCT
bptjm-57	110	1	until	until	SCONJ
bptjm-57	110	2	current	current	ADJ
bptjm-57	110	3	research	research	NOUN
bptjm-57	110	4	shows	show	VERB
bptjm-57	110	5	promising	promise	VERB
bptjm-57	110	6	results	result	NOUN
bptjm-57	110	7	,	,	PUNCT
bptjm-57	110	8	the	the	DET
bptjm-57	110	9	success	success	NOUN
bptjm-57	110	10	of	of	ADP
bptjm-57	110	11	the	the	DET
bptjm-57	110	12	treatment	treatment	NOUN
bptjm-57	110	13	will	will	AUX
bptjm-57	110	14	remain	remain	VERB
bptjm-57	110	15	unknown	unknown	ADJ
bptjm-57	110	16	.	.	PUNCT
bptjm-57	111	1	one	one	NUM
bptjm-57	111	2	clinical	clinical	ADJ
bptjm-57	111	3	trial	trial	NOUN
bptjm-57	111	4	run	run	VERB
bptjm-57	111	5	by	by	ADP
bptjm-57	111	6	fred	fred	PROPN
bptjm-57	111	7	hutchinson	hutchinson	PROPN
bptjm-57	111	8	cancer	cancer	PROPN
bptjm-57	111	9	center	center	PROPN
bptjm-57	111	10	from	from	ADP
bptjm-57	111	11	2016	2016	NUM
bptjm-57	111	12	-	-	SYM
bptjm-57	111	13	2021	2021	NUM
bptjm-57	111	14	investigated	investigate	VERB
bptjm-57	111	15	the	the	DET
bptjm-57	111	16	use	use	NOUN
bptjm-57	111	17	of	of	ADP
bptjm-57	111	18	modi	modi	PROPN
bptjm-57	111	19	�	�	PROPN
bptjm-57	111	20	ed	ed	PROPN
bptjm-57	111	21	car	car	NOUN
bptjm-57	111	22	-	-	PUNCT
bptjm-57	111	23	t	t	NOUN
bptjm-57	111	24	cells	cell	NOUN
bptjm-57	111	25	to	to	ADP
bptjm-57	111	26	�	�	PROPN
bptjm-57	111	27	nd	nd	PART
bptjm-57	111	28	ror1	ror1	ADJ
bptjm-57	111	29	proteins	protein	NOUN
bptjm-57	111	30	on	on	ADP
bptjm-57	111	31	cancer	cancer	NOUN
bptjm-57	111	32	cells	cell	NOUN
bptjm-57	111	33	from	from	ADP
bptjm-57	111	34	di	di	NOUN
bptjm-57	111	35	�	�	PROPN
bptjm-57	111	36	erent	erent	NOUN
bptjm-57	111	37	cancer	cancer	NOUN
bptjm-57	111	38	types	type	NOUN
bptjm-57	111	39	,	,	PUNCT
bptjm-57	111	40	including	include	VERB
bptjm-57	111	41	but	but	CCONJ
bptjm-57	111	42	not	not	PART
bptjm-57	111	43	limited	limit	VERB
bptjm-57	111	44	to	to	ADP
bptjm-57	111	45	non	non	ADJ
bptjm-57	111	46	-	-	ADJ
bptjm-57	111	47	small	small	ADJ
bptjm-57	111	48	cell	cell	NOUN
bptjm-57	111	49	lung	lung	NOUN
bptjm-57	111	50	cancer	cancer	NOUN
bptjm-57	111	51	(	(	PUNCT
bptjm-57	111	52	nsclc	nsclc	NOUN
bptjm-57	111	53	)	)	PUNCT
bptjm-57	111	54	and	and	CCONJ
bptjm-57	111	55	tnbc	tnbc	ADV
bptjm-57	111	56	,	,	PUNCT
bptjm-57	111	57	both	both	PRON
bptjm-57	111	58	of	of	ADP
bptjm-57	111	59	which	which	PRON
bptjm-57	111	60	present	present	ADJ
bptjm-57	111	61	as	as	ADP
bptjm-57	111	62	solid	solid	ADJ
bptjm-57	111	63	tumors	tumor	NOUN
bptjm-57	111	64	.	.	PUNCT
bptjm-57	112	1	participants	participant	NOUN
bptjm-57	112	2	with	with	ADP
bptjm-57	112	3	either	either	CCONJ
bptjm-57	112	4	nsclc	nsclc	NOUN
bptjm-57	112	5	or	or	CCONJ
bptjm-57	112	6	tnbc	tnbc	PROPN
bptjm-57	112	7	had	have	AUX
bptjm-57	112	8	unsuccessfully	unsuccessfully	ADV
bptjm-57	112	9	undergone	undergo	VERB
bptjm-57	112	10	chemotherapy	chemotherapy	NOUN
bptjm-57	112	11	and	and	CCONJ
bptjm-57	112	12	other	other	ADJ
bptjm-57	112	13	traditional	traditional	ADJ
bptjm-57	112	14	treatments	treatment	NOUN
bptjm-57	112	15	.	.	PUNCT
bptjm-57	113	1	upon	upon	SCONJ
bptjm-57	113	2	undergoing	undergo	VERB
bptjm-57	113	3	the	the	DET
bptjm-57	113	4	clinical	clinical	ADJ
bptjm-57	113	5	trial	trial	NOUN
bptjm-57	113	6	,	,	PUNCT
bptjm-57	113	7	all	all	DET
bptjm-57	113	8	patients	patient	NOUN
bptjm-57	113	9	displayed	display	VERB
bptjm-57	113	10	adverse	adverse	ADJ
bptjm-57	113	11	e	e	NOUN
bptjm-57	113	12	�	�	NOUN
bptjm-57	113	13	ects	ect	VERB
bptjm-57	113	14	with	with	ADP
bptjm-57	113	15	mixed	mixed	ADJ
bptjm-57	113	16	responses	response	NOUN
bptjm-57	113	17	to	to	ADP
bptjm-57	113	18	the	the	DET
bptjm-57	113	19	therapy	therapy	NOUN
bptjm-57	113	20	.	.	PUNCT
bptjm-57	114	1	one	one	NUM
bptjm-57	114	2	out	out	ADP
bptjm-57	114	3	of	of	ADP
bptjm-57	114	4	three	three	NUM
bptjm-57	114	5	patients	patient	NOUN
bptjm-57	114	6	in	in	ADP
bptjm-57	114	7	dosage	dosage	NOUN
bptjm-57	114	8	level	level	NOUN
bptjm-57	114	9	2	2	NUM
bptjm-57	114	10	experienced	experience	VERB
bptjm-57	114	11	either	either	CCONJ
bptjm-57	114	12	complete	complete	ADJ
bptjm-57	114	13	or	or	CCONJ
bptjm-57	114	14	partial	partial	ADJ
bptjm-57	114	15	remission	remission	NOUN
bptjm-57	114	16	,	,	PUNCT
bptjm-57	114	17	one	one	NUM
bptjm-57	114	18	out	out	ADP
bptjm-57	114	19	of	of	ADP
bptjm-57	114	20	six	six	NUM
bptjm-57	114	21	patients	patient	NOUN
bptjm-57	114	22	in	in	ADP
bptjm-57	114	23	dosage	dosage	NOUN
bptjm-57	114	24	level	level	NOUN
bptjm-57	114	25	3	3	NUM
bptjm-57	114	26	experienced	experienced	ADJ
bptjm-57	114	27	progression	progression	NOUN
bptjm-57	114	28	-	-	PUNCT
bptjm-57	114	29	free	free	ADJ
bptjm-57	114	30	survival	survival	NOUN
bptjm-57	114	31	after	after	ADP
bptjm-57	114	32	one	one	NUM
bptjm-57	114	33	year	year	NOUN
bptjm-57	114	34	,	,	PUNCT
bptjm-57	114	35	and	and	CCONJ
bptjm-57	114	36	,	,	PUNCT
bptjm-57	114	37	across	across	ADP
bptjm-57	114	38	all	all	DET
bptjm-57	114	39	dosage	dosage	NOUN
bptjm-57	114	40	levels	level	NOUN
bptjm-57	114	41	,	,	PUNCT
bptjm-57	114	42	there	there	PRON
bptjm-57	114	43	was	be	VERB
bptjm-57	114	44	a	a	DET
bptjm-57	114	45	38.89	38.89	NUM
bptjm-57	114	46	%	%	NOUN
bptjm-57	114	47	overall	overall	ADJ
bptjm-57	114	48	survival	survival	PROPN
bptjm-57	114	49	rate.52,53	rate.52,53	NOUN
bptjm-57	114	50	a	a	DET
bptjm-57	114	51	second	second	ADJ
bptjm-57	114	52	study	study	NOUN
bptjm-57	114	53	funded	fund	VERB
bptjm-57	114	54	by	by	ADP
bptjm-57	114	55	the	the	DET
bptjm-57	114	56	national	national	ADJ
bptjm-57	114	57	natural	natural	PROPN
bptjm-57	114	58	science	science	PROPN
bptjm-57	114	59	foundation	foundation	PROPN
bptjm-57	114	60	of	of	ADP
bptjm-57	114	61	china	china	PROPN
bptjm-57	114	62	and	and	CCONJ
bptjm-57	114	63	conducted	conduct	VERB
bptjm-57	114	64	at	at	ADP
bptjm-57	114	65	nanjing	nanjing	PROPN
bptjm-57	114	66	normal	normal	ADJ
bptjm-57	114	67	university	university	NOUN
bptjm-57	114	68	analyzed	analyze	VERB
bptjm-57	114	69	ways	way	NOUN
bptjm-57	114	70	to	to	PART
bptjm-57	114	71	enhance	enhance	VERB
bptjm-57	114	72	car	car	NOUN
bptjm-57	114	73	-	-	PUNCT
bptjm-57	114	74	t	t	NOUN
bptjm-57	114	75	cell	cell	NOUN
bptjm-57	114	76	therapy	therapy	NOUN
bptjm-57	114	77	.	.	PUNCT
bptjm-57	115	1	knowing	know	VERB
bptjm-57	115	2	that	that	DET
bptjm-57	115	3	tigit	tigit	NOUN
bptjm-57	115	4	was	be	AUX
bptjm-57	115	5	a	a	DET
bptjm-57	115	6	suppressor	suppressor	NOUN
bptjm-57	115	7	of	of	ADP
bptjm-57	115	8	anti	anti	ADJ
bptjm-57	115	9	-	-	ADJ
bptjm-57	115	10	tumor	tumor	ADJ
bptjm-57	115	11	processes	process	NOUN
bptjm-57	115	12	and	and	CCONJ
bptjm-57	115	13	that	that	PRON
bptjm-57	115	14	msln	msln	NOUN
bptjm-57	115	15	was	be	AUX
bptjm-57	115	16	highly	highly	ADV
bptjm-57	115	17	expressed	express	VERB
bptjm-57	115	18	in	in	ADP
bptjm-57	115	19	breast	breast	NOUN
bptjm-57	115	20	,	,	PUNCT
bptjm-57	115	21	prostate	prostate	NOUN
bptjm-57	115	22	,	,	PUNCT
bptjm-57	115	23	and	and	CCONJ
bptjm-57	115	24	ovarian	ovarian	ADJ
bptjm-57	115	25	cancers	cancer	NOUN
bptjm-57	115	26	,	,	PUNCT
bptjm-57	115	27	researchers	researcher	NOUN
bptjm-57	115	28	combined	combine	VERB
bptjm-57	115	29	an	an	DET
bptjm-57	115	30	anti	anti	ADJ
bptjm-57	115	31	-	-	ADJ
bptjm-57	115	32	ɑ	ɑ	NOUN
bptjm-57	115	33	-	-	PUNCT
bptjm-57	115	34	tigit	tigit	NOUN
bptjm-57	115	35	with	with	ADP
bptjm-57	115	36	mlsn	mlsn	NOUN
bptjm-57	115	37	car	car	NOUN
bptjm-57	115	38	-	-	PUNCT
bptjm-57	115	39	t	t	NOUN
bptjm-57	115	40	cells	cell	NOUN
bptjm-57	115	41	as	as	ADP
bptjm-57	115	42	a	a	DET
bptjm-57	115	43	treatment	treatment	NOUN
bptjm-57	115	44	.	.	PUNCT
bptjm-57	116	1	this	this	DET
bptjm-57	116	2	combination	combination	NOUN
bptjm-57	116	3	signi	signi	PROPN
bptjm-57	116	4	�	�	PROPN
bptjm-57	116	5	cantly	cantly	PROPN
bptjm-57	116	6	berkeley	berkeley	PROPN
bptjm-57	116	7	pharma	pharma	PROPN
bptjm-57	116	8	tech	tech	NOUN
bptjm-57	116	9	journal	journal	NOUN
bptjm-57	116	10	of	of	ADP
bptjm-57	116	11	medicine	medicine	NOUN
bptjm-57	116	12	|	|	ADV
bptjm-57	116	13	95	95	NUM
bptjm-57	116	14	enhanced	enhance	VERB
bptjm-57	116	15	the	the	DET
bptjm-57	116	16	anti	anti	ADJ
bptjm-57	116	17	-	-	ADJ
bptjm-57	116	18	tumor	tumor	ADJ
bptjm-57	116	19	properties	property	NOUN
bptjm-57	116	20	of	of	ADP
bptjm-57	116	21	mlsncar	mlsncar	NOUN
bptjm-57	116	22	-	-	PUNCT
bptjm-57	116	23	t	t	NOUN
bptjm-57	116	24	cells	cell	NOUN
bptjm-57	116	25	.	.	PUNCT
bptjm-57	117	1	the	the	DET
bptjm-57	117	2	number	number	NOUN
bptjm-57	117	3	of	of	ADP
bptjm-57	117	4	car	car	NOUN
bptjm-57	117	5	-	-	PUNCT
bptjm-57	117	6	t	t	NOUN
bptjm-57	117	7	cells	cell	NOUN
bptjm-57	117	8	positive	positive	ADJ
bptjm-57	117	9	for	for	ADP
bptjm-57	117	10	tigit	tigit	NOUN
bptjm-57	117	11	was	be	AUX
bptjm-57	117	12	initially	initially	ADV
bptjm-57	117	13	18.3	18.3	NUM
bptjm-57	117	14	%	%	NOUN
bptjm-57	117	15	but	but	CCONJ
bptjm-57	117	16	dropped	drop	VERB
bptjm-57	117	17	to	to	ADP
bptjm-57	117	18	1.81	1.81	NUM
bptjm-57	117	19	%	%	NOUN
bptjm-57	117	20	after	after	ADP
bptjm-57	117	21	the	the	DET
bptjm-57	117	22	addition	addition	NOUN
bptjm-57	117	23	of	of	ADP
bptjm-57	117	24	anti	anti	ADJ
bptjm-57	117	25	-	-	ADJ
bptjm-57	117	26	ɑ	ɑ	PRON
bptjm-57	117	27	-	-	PUNCT
bptjm-57	117	28	tigit	tigit	NOUN
bptjm-57	117	29	,	,	PUNCT
bptjm-57	117	30	which	which	PRON
bptjm-57	117	31	led	lead	VERB
bptjm-57	117	32	to	to	ADP
bptjm-57	117	33	a	a	DET
bptjm-57	117	34	more	more	ADJ
bptjm-57	117	35	e	e	NOUN
bptjm-57	117	36	�	�	NOUN
bptjm-57	117	37	cient	cient	NOUN
bptjm-57	117	38	mlsn	mlsn	ADJ
bptjm-57	117	39	car	car	NOUN
bptjm-57	117	40	-	-	PUNCT
bptjm-57	117	41	t	t	NOUN
bptjm-57	117	42	cell	cell	NOUN
bptjm-57	117	43	.	.	PUNCT
bptjm-57	118	1	53additionally	53additionally	ADV
bptjm-57	118	2	,	,	PUNCT
bptjm-57	118	3	a	a	DET
bptjm-57	118	4	third	third	ADJ
bptjm-57	118	5	phase	phase	NOUN
bptjm-57	118	6	i	i	PRON
bptjm-57	118	7	trial	trial	NOUN
bptjm-57	118	8	is	be	AUX
bptjm-57	118	9	ongoing	ongoing	ADJ
bptjm-57	118	10	to	to	PART
bptjm-57	118	11	treat	treat	VERB
bptjm-57	118	12	prostate	prostate	NOUN
bptjm-57	118	13	cancer	cancer	NOUN
bptjm-57	118	14	with	with	ADP
bptjm-57	118	15	car	car	NOUN
bptjm-57	118	16	-	-	PUNCT
bptjm-57	118	17	t	t	NOUN
bptjm-57	118	18	cells	cell	NOUN
bptjm-57	118	19	modi	modi	PROPN
bptjm-57	118	20	�	�	PROPN
bptjm-57	118	21	ed	ed	PROPN
bptjm-57	118	22	for	for	ADP
bptjm-57	118	23	psca	psca	NOUN
bptjm-57	118	24	.	.	PUNCT
bptjm-57	119	1	the	the	DET
bptjm-57	119	2	city	city	NOUN
bptjm-57	119	3	of	of	ADP
bptjm-57	119	4	hope	hope	PROPN
bptjm-57	119	5	medical	medical	ADJ
bptjm-57	119	6	center	center	NOUN
bptjm-57	119	7	began	begin	VERB
bptjm-57	119	8	this	this	DET
bptjm-57	119	9	study	study	NOUN
bptjm-57	119	10	in	in	ADP
bptjm-57	119	11	2019	2019	NUM
bptjm-57	119	12	and	and	CCONJ
bptjm-57	119	13	it	it	PRON
bptjm-57	119	14	is	be	AUX
bptjm-57	119	15	estimated	estimate	VERB
bptjm-57	119	16	to	to	PART
bptjm-57	119	17	complete	complete	VERB
bptjm-57	119	18	in	in	ADP
bptjm-57	119	19	late	late	ADJ
bptjm-57	119	20	2023	2023	NUM
bptjm-57	119	21	/	/	SYM
bptjm-57	119	22	early	early	ADJ
bptjm-57	119	23	2024	2024	NUM
bptjm-57	119	24	.	.	PUNCT
bptjm-57	120	1	no	no	DET
bptjm-57	120	2	current	current	ADJ
bptjm-57	120	3	results	result	NOUN
bptjm-57	120	4	are	be	AUX
bptjm-57	120	5	available.53,55	available.53,55	ADJ
bptjm-57	120	6	figure	figure	NOUN
bptjm-57	120	7	2	2	NUM
bptjm-57	120	8	.	.	PUNCT
bptjm-57	120	9	car	car	NOUN
bptjm-57	120	10	-	-	PUNCT
bptjm-57	120	11	t	t	NOUN
bptjm-57	120	12	cell	cell	NOUN
bptjm-57	120	13	therapy	therapy	NOUN
bptjm-57	120	14	procedure	procedure	NOUN
bptjm-57	120	15	.	.	PUNCT
bptjm-57	121	1	in	in	ADP
bptjm-57	121	2	car	car	NOUN
bptjm-57	121	3	-	-	PUNCT
bptjm-57	121	4	t	t	NOUN
bptjm-57	121	5	cell	cell	NOUN
bptjm-57	121	6	therapy	therapy	NOUN
bptjm-57	121	7	,	,	PUNCT
bptjm-57	121	8	blood	blood	NOUN
bptjm-57	121	9	is	be	AUX
bptjm-57	121	10	�	�	PROPN
bptjm-57	121	11	rst	rst	PROPN
bptjm-57	121	12	removed	remove	VERB
bptjm-57	121	13	from	from	ADP
bptjm-57	121	14	the	the	DET
bptjm-57	121	15	patient	patient	NOUN
bptjm-57	121	16	to	to	PART
bptjm-57	121	17	obtain	obtain	VERB
bptjm-57	121	18	their	their	PRON
bptjm-57	121	19	t	t	NOUN
bptjm-57	121	20	cells	cell	NOUN
bptjm-57	121	21	.	.	PUNCT
bptjm-57	122	1	car	car	NOUN
bptjm-57	122	2	-	-	PUNCT
bptjm-57	122	3	t	t	NOUN
bptjm-57	122	4	cells	cell	NOUN
bptjm-57	122	5	are	be	AUX
bptjm-57	122	6	then	then	ADV
bptjm-57	122	7	engineered	engineer	VERB
bptjm-57	122	8	and	and	CCONJ
bptjm-57	122	9	grown	grow	VERB
bptjm-57	122	10	in	in	ADP
bptjm-57	122	11	the	the	DET
bptjm-57	122	12	laboratory	laboratory	NOUN
bptjm-57	122	13	before	before	ADP
bptjm-57	122	14	being	be	AUX
bptjm-57	122	15	infused	infuse	VERB
bptjm-57	122	16	back	back	ADV
bptjm-57	122	17	into	into	ADP
bptjm-57	122	18	the	the	DET
bptjm-57	122	19	patient	patient	NOUN
bptjm-57	122	20	.	.	PUNCT
bptjm-57	123	1	in	in	ADP
bptjm-57	123	2	the	the	DET
bptjm-57	123	3	patient	patient	NOUN
bptjm-57	123	4	,	,	PUNCT
bptjm-57	123	5	the	the	DET
bptjm-57	123	6	car	car	NOUN
bptjm-57	123	7	-	-	PUNCT
bptjm-57	123	8	t	t	NOUN
bptjm-57	123	9	cells	cell	NOUN
bptjm-57	123	10	would	would	AUX
bptjm-57	123	11	target	target	VERB
bptjm-57	123	12	and	and	CCONJ
bptjm-57	123	13	bind	bind	VERB
bptjm-57	123	14	to	to	ADP
bptjm-57	123	15	speci	speci	PROPN
bptjm-57	123	16	�	�	PROPN
bptjm-57	123	17	c	c	PROPN
bptjm-57	123	18	antigens	antigen	NOUN
bptjm-57	123	19	present	present	ADJ
bptjm-57	123	20	on	on	ADP
bptjm-57	123	21	the	the	DET
bptjm-57	123	22	tumor	tumor	NOUN
bptjm-57	123	23	cells	cell	NOUN
bptjm-57	123	24	,	,	PUNCT
bptjm-57	123	25	killing	kill	VERB
bptjm-57	123	26	them	they	PRON
bptjm-57	123	27	.	.	PUNCT
bptjm-57	124	1	in	in	ADP
bptjm-57	124	2	the	the	DET
bptjm-57	124	3	long	long	ADJ
bptjm-57	124	4	term	term	NOUN
bptjm-57	124	5	,	,	PUNCT
bptjm-57	124	6	however	however	ADV
bptjm-57	124	7	,	,	PUNCT
bptjm-57	124	8	the	the	DET
bptjm-57	124	9	tumor	tumor	NOUN
bptjm-57	124	10	could	could	AUX
bptjm-57	124	11	acquire	acquire	VERB
bptjm-57	124	12	resistance	resistance	NOUN
bptjm-57	124	13	to	to	ADP
bptjm-57	124	14	this	this	DET
bptjm-57	124	15	therapy	therapy	NOUN
bptjm-57	124	16	through	through	ADP
bptjm-57	124	17	antigen	antigen	ADJ
bptjm-57	124	18	loss	loss	NOUN
bptjm-57	124	19	.	.	PUNCT
bptjm-57	125	1	a	a	DET
bptjm-57	125	2	more	more	ADV
bptjm-57	125	3	common	common	ADJ
bptjm-57	125	4	type	type	NOUN
bptjm-57	125	5	of	of	ADP
bptjm-57	125	6	immunotherapy	immunotherapy	NOUN
bptjm-57	125	7	treatment	treatment	NOUN
bptjm-57	125	8	is	be	AUX
bptjm-57	125	9	immune	immune	ADJ
bptjm-57	125	10	checkpoint	checkpoint	NOUN
bptjm-57	125	11	inhibitors	inhibitor	NOUN
bptjm-57	125	12	(	(	PUNCT
bptjm-57	125	13	icis	icis	NOUN
bptjm-57	125	14	)	)	PUNCT
bptjm-57	125	15	.	.	PUNCT
bptjm-57	126	1	these	these	DET
bptjm-57	126	2	checkpoints	checkpoint	NOUN
bptjm-57	126	3	are	be	AUX
bptjm-57	126	4	part	part	NOUN
bptjm-57	126	5	of	of	ADP
bptjm-57	126	6	the	the	DET
bptjm-57	126	7	immune	immune	ADJ
bptjm-57	126	8	system	system	NOUN
bptjm-57	126	9	and	and	CCONJ
bptjm-57	126	10	prevent	prevent	VERB
bptjm-57	126	11	immune	immune	ADJ
bptjm-57	126	12	cells	cell	NOUN
bptjm-57	126	13	from	from	ADP
bptjm-57	126	14	reacting	react	VERB
bptjm-57	126	15	too	too	ADV
bptjm-57	126	16	aggressively	aggressively	ADV
bptjm-57	126	17	and	and	CCONJ
bptjm-57	126	18	attacking	attack	VERB
bptjm-57	126	19	bene	bene	PROPN
bptjm-57	126	20	�	�	PROPN
bptjm-57	126	21	cial	cial	PROPN
bptjm-57	126	22	cells.50	cells.50	PROPN
bptjm-57	126	23	however	however	ADV
bptjm-57	126	24	,	,	PUNCT
bptjm-57	126	25	these	these	DET
bptjm-57	126	26	checkpoints	checkpoint	NOUN
bptjm-57	126	27	can	can	AUX
bptjm-57	126	28	also	also	ADV
bptjm-57	126	29	prevent	prevent	VERB
bptjm-57	126	30	the	the	DET
bptjm-57	126	31	immune	immune	ADJ
bptjm-57	126	32	system	system	NOUN
bptjm-57	126	33	from	from	ADP
bptjm-57	126	34	e	e	NOUN
bptjm-57	126	35	�	�	NOUN
bptjm-57	126	36	ectively	ectively	ADV
bptjm-57	126	37	dealing	deal	VERB
bptjm-57	126	38	with	with	ADP
bptjm-57	126	39	cancer	cancer	NOUN
bptjm-57	126	40	cells	cell	NOUN
bptjm-57	126	41	.	.	PUNCT
bptjm-57	127	1	hence	hence	ADV
bptjm-57	127	2	,	,	PUNCT
bptjm-57	127	3	by	by	ADP
bptjm-57	127	4	blocking	block	VERB
bptjm-57	127	5	these	these	DET
bptjm-57	127	6	checkpoints	checkpoint	NOUN
bptjm-57	127	7	,	,	PUNCT
bptjm-57	127	8	scientists	scientist	NOUN
bptjm-57	127	9	are	be	AUX
bptjm-57	127	10	able	able	ADJ
bptjm-57	127	11	to	to	PART
bptjm-57	127	12	permit	permit	VERB
bptjm-57	127	13	the	the	DET
bptjm-57	127	14	immune	immune	ADJ
bptjm-57	127	15	system	system	NOUN
bptjm-57	127	16	to	to	PART
bptjm-57	127	17	start	start	VERB
bptjm-57	127	18	berkeley	berkeley	PROPN
bptjm-57	127	19	pharma	pharma	PROPN
bptjm-57	127	20	tech	tech	NOUN
bptjm-57	127	21	journal	journal	NOUN
bptjm-57	127	22	of	of	ADP
bptjm-57	127	23	medicine	medicine	NOUN
bptjm-57	127	24	|	|	ADV
bptjm-57	127	25	96	96	NUM
bptjm-57	127	26	treating	treat	VERB
bptjm-57	127	27	the	the	DET
bptjm-57	127	28	cancer	cancer	NOUN
bptjm-57	127	29	cells	cell	NOUN
bptjm-57	127	30	fully	fully	ADV
bptjm-57	127	31	.	.	PUNCT
bptjm-57	128	1	the	the	DET
bptjm-57	128	2	most	most	ADV
bptjm-57	128	3	common	common	ADJ
bptjm-57	128	4	immune	immune	ADJ
bptjm-57	128	5	checkpoints	checkpoint	NOUN
bptjm-57	128	6	targeted	target	VERB
bptjm-57	128	7	are	be	AUX
bptjm-57	128	8	cytotoxic	cytotoxic	ADJ
bptjm-57	128	9	-	-	PUNCT
bptjm-57	128	10	t	t	NOUN
bptjm-57	128	11	-	-	PUNCT
bptjm-57	128	12	lymphocytes	lymphocyte	NOUN
bptjm-57	128	13	-	-	PUNCT
bptjm-57	128	14	associated	associate	VERB
bptjm-57	128	15	proteins	protein	NOUN
bptjm-57	128	16	(	(	PUNCT
bptjm-57	128	17	ctla-4	ctla-4	NOUN
bptjm-57	128	18	)	)	PUNCT
bptjm-57	128	19	,	,	PUNCT
bptjm-57	128	20	programmed	program	VERB
bptjm-57	128	21	cell	cell	NOUN
bptjm-57	128	22	death	death	NOUN
bptjm-57	128	23	1	1	NUM
bptjm-57	128	24	(	(	PUNCT
bptjm-57	128	25	pd-1	pd-1	ADJ
bptjm-57	128	26	)	)	PUNCT
bptjm-57	128	27	,	,	PUNCT
bptjm-57	128	28	and	and	CCONJ
bptjm-57	128	29	programmed	program	VERB
bptjm-57	128	30	cell	cell	NOUN
bptjm-57	128	31	death	death	NOUN
bptjm-57	128	32	ligand	ligand	NOUN
bptjm-57	128	33	1	1	NUM
bptjm-57	128	34	(	(	PUNCT
bptjm-57	128	35	pd	pd	NOUN
bptjm-57	128	36	-	-	ADJ
bptjm-57	128	37	l1).56figure	l1).56figure	ADJ
bptjm-57	128	38	3	3	NUM
bptjm-57	128	39	shows	show	VERB
bptjm-57	128	40	the	the	DET
bptjm-57	128	41	mechanism	mechanism	NOUN
bptjm-57	128	42	of	of	ADP
bptjm-57	128	43	this	this	DET
bptjm-57	128	44	checkpoint	checkpoint	NOUN
bptjm-57	128	45	blockade	blockade	NOUN
bptjm-57	128	46	.	.	PUNCT
bptjm-57	129	1	there	there	PRON
bptjm-57	129	2	are	be	VERB
bptjm-57	129	3	a	a	DET
bptjm-57	129	4	variety	variety	NOUN
bptjm-57	129	5	of	of	ADP
bptjm-57	129	6	clinical	clinical	ADJ
bptjm-57	129	7	trials	trial	NOUN
bptjm-57	129	8	that	that	PRON
bptjm-57	129	9	involve	involve	VERB
bptjm-57	129	10	icis	icis	PROPN
bptjm-57	129	11	.	.	PUNCT
bptjm-57	130	1	many	many	ADJ
bptjm-57	130	2	of	of	ADP
bptjm-57	130	3	them	they	PRON
bptjm-57	130	4	use	use	VERB
bptjm-57	130	5	combination	combination	NOUN
bptjm-57	130	6	therapy	therapy	NOUN
bptjm-57	130	7	by	by	ADP
bptjm-57	130	8	combining	combine	VERB
bptjm-57	130	9	one	one	NUM
bptjm-57	130	10	of	of	ADP
bptjm-57	130	11	the	the	DET
bptjm-57	130	12	seven	seven	NUM
bptjm-57	130	13	fda	fda	PROPN
bptjm-57	130	14	-	-	PUNCT
bptjm-57	130	15	approved	approve	VERB
bptjm-57	130	16	ici	ici	NOUN
bptjm-57	130	17	treatments	treatment	NOUN
bptjm-57	130	18	with	with	ADP
bptjm-57	130	19	either	either	CCONJ
bptjm-57	130	20	another	another	DET
bptjm-57	130	21	approved	approve	VERB
bptjm-57	130	22	ici	ici	NOUN
bptjm-57	130	23	treatment	treatment	NOUN
bptjm-57	130	24	or	or	CCONJ
bptjm-57	130	25	with	with	ADP
bptjm-57	130	26	another	another	DET
bptjm-57	130	27	therapy	therapy	NOUN
bptjm-57	130	28	like	like	ADP
bptjm-57	130	29	chemotherapy.56	chemotherapy.56	VERB
bptjm-57	130	30	a	a	DET
bptjm-57	130	31	clinical	clinical	ADJ
bptjm-57	130	32	trial	trial	NOUN
bptjm-57	130	33	run	run	VERB
bptjm-57	130	34	by	by	ADP
bptjm-57	130	35	bristol	bristol	NOUN
bptjm-57	130	36	-	-	PUNCT
bptjm-57	130	37	myers	myers	PROPN
bptjm-57	130	38	squibb	squibb	PROPN
bptjm-57	130	39	from	from	ADP
bptjm-57	130	40	2016	2016	NUM
bptjm-57	130	41	-	-	SYM
bptjm-57	130	42	2023	2023	NUM
bptjm-57	130	43	tested	test	VERB
bptjm-57	130	44	the	the	DET
bptjm-57	130	45	combination	combination	NOUN
bptjm-57	130	46	of	of	ADP
bptjm-57	130	47	ipilimumab	ipilimumab	NOUN
bptjm-57	130	48	and	and	CCONJ
bptjm-57	130	49	nivolumab	nivolumab	NOUN
bptjm-57	130	50	(	(	PUNCT
bptjm-57	130	51	treatment	treatment	NOUN
bptjm-57	130	52	a	a	PRON
bptjm-57	130	53	,	,	PUNCT
bptjm-57	130	54	immunotherapy	immunotherapy	NOUN
bptjm-57	130	55	)	)	PUNCT
bptjm-57	130	56	against	against	ADP
bptjm-57	130	57	pemetrexed	pemetrexed	NOUN
bptjm-57	130	58	and	and	CCONJ
bptjm-57	130	59	cisplatin	cisplatin	NOUN
bptjm-57	130	60	or	or	CCONJ
bptjm-57	130	61	carboplatin	carboplatin	NOUN
bptjm-57	130	62	(	(	PUNCT
bptjm-57	130	63	treatment	treatment	NOUN
bptjm-57	130	64	b	b	NOUN
bptjm-57	130	65	,	,	PUNCT
bptjm-57	130	66	type	type	NOUN
bptjm-57	130	67	of	of	ADP
bptjm-57	130	68	chemotherapy	chemotherapy	NOUN
bptjm-57	130	69	)	)	PUNCT
bptjm-57	130	70	in	in	ADP
bptjm-57	130	71	malignant	malignant	ADJ
bptjm-57	130	72	pleural	pleural	ADJ
bptjm-57	130	73	mesothelioma	mesothelioma	NOUN
bptjm-57	130	74	(	(	PUNCT
bptjm-57	130	75	mpm	mpm	NOUN
bptjm-57	130	76	)	)	PUNCT
bptjm-57	130	77	.	.	PUNCT
bptjm-57	131	1	treatment	treatment	NOUN
bptjm-57	131	2	a	a	PRON
bptjm-57	131	3	had	have	VERB
bptjm-57	131	4	an	an	DET
bptjm-57	131	5	overall	overall	ADJ
bptjm-57	131	6	survival	survival	NOUN
bptjm-57	131	7	that	that	PRON
bptjm-57	131	8	was	be	AUX
bptjm-57	131	9	,	,	PUNCT
bptjm-57	131	10	on	on	ADP
bptjm-57	131	11	average	average	ADJ
bptjm-57	131	12	,	,	PUNCT
bptjm-57	131	13	four	four	NUM
bptjm-57	131	14	months	month	NOUN
bptjm-57	131	15	longer	long	ADV
bptjm-57	131	16	than	than	ADP
bptjm-57	131	17	treatment	treatment	NOUN
bptjm-57	131	18	b.	b.	PROPN
bptjm-57	132	1	the	the	DET
bptjm-57	132	2	median	median	ADJ
bptjm-57	132	3	disease	disease	NOUN
bptjm-57	132	4	control	control	NOUN
bptjm-57	132	5	rates	rate	NOUN
bptjm-57	132	6	for	for	ADP
bptjm-57	132	7	treatment	treatment	NOUN
bptjm-57	132	8	a	a	PRON
bptjm-57	132	9	and	and	CCONJ
bptjm-57	132	10	treatment	treatment	NOUN
bptjm-57	132	11	b	b	PROPN
bptjm-57	132	12	were	be	AUX
bptjm-57	132	13	76.6	76.6	NUM
bptjm-57	132	14	%	%	NOUN
bptjm-57	132	15	and	and	CCONJ
bptjm-57	132	16	85.1	85.1	NUM
bptjm-57	132	17	%	%	NOUN
bptjm-57	132	18	,	,	PUNCT
bptjm-57	132	19	respectively.57	respectively.57	PROPN
bptjm-57	132	20	in	in	ADP
bptjm-57	132	21	a	a	DET
bptjm-57	132	22	three	three	NUM
bptjm-57	132	23	-	-	PUNCT
bptjm-57	132	24	year	year	NOUN
bptjm-57	132	25	minimum	minimum	ADJ
bptjm-57	132	26	follow	follow	NOUN
bptjm-57	132	27	-	-	PUNCT
bptjm-57	132	28	up	up	NOUN
bptjm-57	132	29	,	,	PUNCT
bptjm-57	132	30	the	the	DET
bptjm-57	132	31	trial	trial	NOUN
bptjm-57	132	32	showed	show	VERB
bptjm-57	132	33	overall	overall	ADJ
bptjm-57	132	34	survival	survival	NOUN
bptjm-57	132	35	rates	rate	NOUN
bptjm-57	132	36	of	of	ADP
bptjm-57	132	37	23	23	NUM
bptjm-57	132	38	%	%	NOUN
bptjm-57	132	39	and	and	CCONJ
bptjm-57	132	40	15	15	NUM
bptjm-57	132	41	%	%	NOUN
bptjm-57	132	42	for	for	ADP
bptjm-57	132	43	treatment	treatment	NOUN
bptjm-57	132	44	a	a	PRON
bptjm-57	132	45	and	and	CCONJ
bptjm-57	132	46	treatment	treatment	NOUN
bptjm-57	132	47	b	b	NOUN
bptjm-57	132	48	respectively	respectively	ADV
bptjm-57	132	49	.	.	PUNCT
bptjm-57	133	1	moreover	moreover	ADV
bptjm-57	133	2	,	,	PUNCT
bptjm-57	133	3	at	at	ADP
bptjm-57	133	4	three	three	NUM
bptjm-57	133	5	years	year	NOUN
bptjm-57	133	6	,	,	PUNCT
bptjm-57	133	7	28	28	NUM
bptjm-57	133	8	%	%	NOUN
bptjm-57	133	9	of	of	ADP
bptjm-57	133	10	patients	patient	NOUN
bptjm-57	133	11	had	have	VERB
bptjm-57	133	12	an	an	DET
bptjm-57	133	13	ongoing	ongoing	ADJ
bptjm-57	133	14	response	response	NOUN
bptjm-57	133	15	to	to	ADP
bptjm-57	133	16	treatment	treatment	NOUN
bptjm-57	133	17	a	a	DET
bptjm-57	133	18	while	while	NOUN
bptjm-57	133	19	treatment	treatment	NOUN
bptjm-57	133	20	b	b	PROPN
bptjm-57	133	21	had	have	VERB
bptjm-57	133	22	0	0	NUM
bptjm-57	133	23	%	%	NOUN
bptjm-57	133	24	patients	patient	NOUN
bptjm-57	133	25	with	with	ADP
bptjm-57	133	26	ongoing	ongoing	ADJ
bptjm-57	133	27	response.58	response.58	NOUN
bptjm-57	133	28	these	these	DET
bptjm-57	133	29	results	result	NOUN
bptjm-57	133	30	demonstrate	demonstrate	VERB
bptjm-57	133	31	how	how	SCONJ
bptjm-57	133	32	the	the	DET
bptjm-57	133	33	combination	combination	NOUN
bptjm-57	133	34	of	of	ADP
bptjm-57	133	35	nivolumab	nivolumab	NOUN
bptjm-57	133	36	and	and	CCONJ
bptjm-57	133	37	ipilimumab	ipilimumab	NOUN
bptjm-57	133	38	continued	continue	VERB
bptjm-57	133	39	to	to	PART
bptjm-57	133	40	provide	provide	VERB
bptjm-57	133	41	long	long	ADJ
bptjm-57	133	42	-	-	PUNCT
bptjm-57	133	43	term	term	NOUN
bptjm-57	133	44	survival	survival	NOUN
bptjm-57	133	45	bene	bene	PROPN
bptjm-57	133	46	�	�	PROPN
bptjm-57	133	47	t	t	PROPN
bptjm-57	133	48	over	over	ADP
bptjm-57	133	49	chemotherapy	chemotherapy	NOUN
bptjm-57	133	50	,	,	PUNCT
bptjm-57	133	51	supporting	support	VERB
bptjm-57	133	52	this	this	DET
bptjm-57	133	53	combination	combination	NOUN
bptjm-57	133	54	of	of	ADP
bptjm-57	133	55	icis	icis	NOUN
bptjm-57	133	56	as	as	ADP
bptjm-57	133	57	a	a	DET
bptjm-57	133	58	�	�	PROPN
bptjm-57	133	59	rst	rst	ADJ
bptjm-57	133	60	-	-	PUNCT
bptjm-57	133	61	line	line	NOUN
bptjm-57	133	62	treatment	treatment	NOUN
bptjm-57	133	63	for	for	ADP
bptjm-57	133	64	unresectable	unresectable	ADJ
bptjm-57	133	65	mpm	mpm	NOUN
bptjm-57	133	66	.	.	PUNCT
bptjm-57	134	1	berkeley	berkeley	PROPN
bptjm-57	134	2	pharma	pharma	PROPN
bptjm-57	134	3	tech	tech	PROPN
bptjm-57	134	4	journal	journal	NOUN
bptjm-57	134	5	of	of	ADP
bptjm-57	134	6	medicine	medicine	NOUN
bptjm-57	134	7	|	|	ADV
bptjm-57	134	8	97	97	NUM
bptjm-57	134	9	figure	figure	NOUN
bptjm-57	134	10	3	3	NUM
bptjm-57	134	11	.	.	PUNCT
bptjm-57	134	12	mechanism	mechanism	NOUN
bptjm-57	134	13	of	of	ADP
bptjm-57	134	14	immune	immune	ADJ
bptjm-57	134	15	checkpoint	checkpoint	NOUN
bptjm-57	134	16	inhibitors	inhibitor	NOUN
bptjm-57	134	17	.	.	PUNCT
bptjm-57	135	1	(	(	PUNCT
bptjm-57	135	2	a	a	X
bptjm-57	135	3	)	)	PUNCT
bptjm-57	135	4	an	an	DET
bptjm-57	135	5	antigen	antigen	NOUN
bptjm-57	135	6	-	-	PUNCT
bptjm-57	135	7	presenting	present	VERB
bptjm-57	135	8	cell	cell	NOUN
bptjm-57	135	9	(	(	PUNCT
bptjm-57	135	10	apc	apc	PROPN
bptjm-57	135	11	)	)	PUNCT
bptjm-57	135	12	displays	display	VERB
bptjm-57	135	13	an	an	DET
bptjm-57	135	14	antigen	antigen	NOUN
bptjm-57	135	15	bound	bind	VERB
bptjm-57	135	16	by	by	ADP
bptjm-57	135	17	the	the	DET
bptjm-57	135	18	major	major	ADJ
bptjm-57	135	19	histocompatibility	histocompatibility	NOUN
bptjm-57	135	20	complex	complex	NOUN
bptjm-57	135	21	(	(	PUNCT
bptjm-57	135	22	mhc	mhc	PROPN
bptjm-57	135	23	)	)	PUNCT
bptjm-57	135	24	.	.	PUNCT
bptjm-57	136	1	t	t	NOUN
bptjm-57	136	2	cell	cell	NOUN
bptjm-57	136	3	receptors	receptor	NOUN
bptjm-57	136	4	(	(	PUNCT
bptjm-57	136	5	tcr	tcr	PROPN
bptjm-57	136	6	)	)	PUNCT
bptjm-57	136	7	recognize	recognize	VERB
bptjm-57	136	8	the	the	DET
bptjm-57	136	9	antigen	antigen	NOUN
bptjm-57	136	10	,	,	PUNCT
bptjm-57	136	11	causing	cause	VERB
bptjm-57	136	12	interaction	interaction	NOUN
bptjm-57	136	13	between	between	ADP
bptjm-57	136	14	the	the	DET
bptjm-57	136	15	t	t	NOUN
bptjm-57	136	16	cell	cell	NOUN
bptjm-57	136	17	and	and	CCONJ
bptjm-57	136	18	the	the	DET
bptjm-57	136	19	apc	apc	PROPN
bptjm-57	136	20	or	or	CCONJ
bptjm-57	136	21	tumor	tumor	NOUN
bptjm-57	136	22	cell	cell	NOUN
bptjm-57	136	23	.	.	PUNCT
bptjm-57	137	1	a	a	DET
bptjm-57	137	2	co	co	ADJ
bptjm-57	137	3	-	-	ADJ
bptjm-57	137	4	stimulatory	stimulatory	ADJ
bptjm-57	137	5	signal	signal	NOUN
bptjm-57	137	6	caused	cause	VERB
bptjm-57	137	7	by	by	ADP
bptjm-57	137	8	cd80/86	cd80/86	NOUN
bptjm-57	137	9	binding	bind	VERB
bptjm-57	137	10	to	to	ADP
bptjm-57	137	11	cd28	cd28	PROPN
bptjm-57	137	12	results	result	VERB
bptjm-57	137	13	in	in	ADP
bptjm-57	137	14	t	t	NOUN
bptjm-57	137	15	cell	cell	NOUN
bptjm-57	137	16	activation	activation	NOUN
bptjm-57	137	17	and	and	CCONJ
bptjm-57	137	18	proliferation	proliferation	NOUN
bptjm-57	137	19	,	,	PUNCT
bptjm-57	137	20	allowing	allow	VERB
bptjm-57	137	21	the	the	DET
bptjm-57	137	22	t	t	NOUN
bptjm-57	137	23	cell	cell	NOUN
bptjm-57	137	24	to	to	PART
bptjm-57	137	25	kill	kill	VERB
bptjm-57	137	26	the	the	DET
bptjm-57	137	27	cancer	cancer	NOUN
bptjm-57	137	28	cell	cell	NOUN
bptjm-57	137	29	.	.	PUNCT
bptjm-57	138	1	(	(	PUNCT
bptjm-57	138	2	b	b	X
bptjm-57	138	3	)	)	PUNCT
bptjm-57	138	4	when	when	SCONJ
bptjm-57	138	5	ctla-4	ctla-4	NOUN
bptjm-57	138	6	is	be	AUX
bptjm-57	138	7	present	present	ADJ
bptjm-57	138	8	on	on	ADP
bptjm-57	138	9	a	a	DET
bptjm-57	138	10	t	t	NOUN
bptjm-57	138	11	cell	cell	NOUN
bptjm-57	138	12	,	,	PUNCT
bptjm-57	138	13	it	it	PRON
bptjm-57	138	14	binds	bind	VERB
bptjm-57	138	15	to	to	ADP
bptjm-57	138	16	cd80/86	cd80/86	NOUN
bptjm-57	138	17	in	in	ADP
bptjm-57	138	18	place	place	NOUN
bptjm-57	138	19	of	of	ADP
bptjm-57	138	20	cd28	cd28	PROPN
bptjm-57	138	21	.	.	PUNCT
bptjm-57	139	1	pd-1	pd-1	VERB
bptjm-57	139	2	on	on	ADP
bptjm-57	139	3	t	t	PROPN
bptjm-57	139	4	cells	cell	NOUN
bptjm-57	139	5	also	also	ADV
bptjm-57	139	6	bind	bind	VERB
bptjm-57	139	7	to	to	ADP
bptjm-57	139	8	pd	pd	PROPN
bptjm-57	139	9	-	-	PROPN
bptjm-57	139	10	l1	l1	PROPN
bptjm-57	139	11	that	that	PRON
bptjm-57	139	12	are	be	AUX
bptjm-57	139	13	present	present	ADJ
bptjm-57	139	14	on	on	ADP
bptjm-57	139	15	tumor	tumor	NOUN
bptjm-57	139	16	cells	cell	NOUN
bptjm-57	139	17	.	.	PUNCT
bptjm-57	140	1	both	both	PRON
bptjm-57	140	2	of	of	ADP
bptjm-57	140	3	these	these	DET
bptjm-57	140	4	interactions	interaction	NOUN
bptjm-57	140	5	lead	lead	VERB
bptjm-57	140	6	to	to	ADP
bptjm-57	140	7	an	an	DET
bptjm-57	140	8	inhibitory	inhibitory	ADJ
bptjm-57	140	9	signal	signal	NOUN
bptjm-57	140	10	that	that	PRON
bptjm-57	140	11	blocks	block	VERB
bptjm-57	140	12	the	the	DET
bptjm-57	140	13	t	t	NOUN
bptjm-57	140	14	cell	cell	NOUN
bptjm-57	140	15	from	from	ADP
bptjm-57	140	16	killing	kill	VERB
bptjm-57	140	17	the	the	DET
bptjm-57	140	18	cancer	cancer	NOUN
bptjm-57	140	19	cell	cell	NOUN
bptjm-57	140	20	.	.	PUNCT
bptjm-57	141	1	(	(	PUNCT
bptjm-57	141	2	c	c	X
bptjm-57	141	3	)	)	PUNCT
bptjm-57	141	4	anti	anti	ADJ
bptjm-57	141	5	-	-	ADJ
bptjm-57	141	6	ctla-4	ctla-4	NOUN
bptjm-57	141	7	binds	bind	VERB
bptjm-57	141	8	to	to	ADP
bptjm-57	141	9	ctla-4	ctla-4	NUM
bptjm-57	141	10	,	,	PUNCT
bptjm-57	141	11	blocking	block	VERB
bptjm-57	141	12	its	its	PRON
bptjm-57	141	13	interaction	interaction	NOUN
bptjm-57	141	14	with	with	ADP
bptjm-57	141	15	cd80/86	cd80/86	NOUN
bptjm-57	141	16	.	.	PUNCT
bptjm-57	142	1	this	this	PRON
bptjm-57	142	2	allows	allow	VERB
bptjm-57	142	3	for	for	ADP
bptjm-57	142	4	binding	bind	VERB
bptjm-57	142	5	of	of	ADP
bptjm-57	142	6	cd28	cd28	PROPN
bptjm-57	142	7	to	to	ADP
bptjm-57	142	8	cd80/86	cd80/86	NOUN
bptjm-57	142	9	,	,	PUNCT
bptjm-57	142	10	producing	produce	VERB
bptjm-57	142	11	a	a	DET
bptjm-57	142	12	co	co	ADJ
bptjm-57	142	13	-	-	ADJ
bptjm-57	142	14	stimulatory	stimulatory	ADJ
bptjm-57	142	15	signal	signal	NOUN
bptjm-57	142	16	.	.	PUNCT
bptjm-57	143	1	similarly	similarly	ADV
bptjm-57	143	2	,	,	PUNCT
bptjm-57	143	3	anti	anti	ADJ
bptjm-57	143	4	-	-	ADJ
bptjm-57	143	5	pd-1	pd-1	ADJ
bptjm-57	143	6	binds	bind	VERB
bptjm-57	143	7	to	to	ADP
bptjm-57	143	8	pd-1	pd-1	X
bptjm-57	143	9	while	while	SCONJ
bptjm-57	143	10	anti	anti	ADJ
bptjm-57	143	11	-	-	ADJ
bptjm-57	143	12	pd	pd	ADJ
bptjm-57	143	13	-	-	PUNCT
bptjm-57	143	14	l1	l1	PROPN
bptjm-57	143	15	binds	bind	VERB
bptjm-57	143	16	to	to	ADP
bptjm-57	143	17	pd	pd	NOUN
bptjm-57	143	18	-	-	PUNCT
bptjm-57	143	19	l1	l1	PROPN
bptjm-57	143	20	,	,	PUNCT
bptjm-57	143	21	blocking	block	VERB
bptjm-57	143	22	pd-1	pd-1	ADP
bptjm-57	143	23	and	and	CCONJ
bptjm-57	143	24	pd	pd	PROPN
bptjm-57	143	25	-	-	PUNCT
bptjm-57	143	26	l1	l1	PROPN
bptjm-57	143	27	interactions	interaction	NOUN
bptjm-57	143	28	.	.	PUNCT
bptjm-57	144	1	thus	thus	ADV
bptjm-57	144	2	,	,	PUNCT
bptjm-57	144	3	through	through	ADP
bptjm-57	144	4	immune	immune	ADJ
bptjm-57	144	5	checkpoint	checkpoint	NOUN
bptjm-57	144	6	inhibition	inhibition	NOUN
bptjm-57	144	7	,	,	PUNCT
bptjm-57	144	8	t	t	NOUN
bptjm-57	144	9	cells	cell	NOUN
bptjm-57	144	10	are	be	AUX
bptjm-57	144	11	reactivated	reactivate	VERB
bptjm-57	144	12	and	and	CCONJ
bptjm-57	144	13	can	can	AUX
bptjm-57	144	14	kill	kill	VERB
bptjm-57	144	15	tumor	tumor	NOUN
bptjm-57	144	16	cells	cell	NOUN
bptjm-57	144	17	.	.	PUNCT
bptjm-57	145	1	3.2	3.2	NUM
bptjm-57	145	2	combination	combination	NOUN
bptjm-57	145	3	therapy	therapy	NOUN
bptjm-57	145	4	combination	combination	NOUN
bptjm-57	145	5	therapy	therapy	NOUN
bptjm-57	145	6	involves	involve	VERB
bptjm-57	145	7	using	use	VERB
bptjm-57	145	8	multiple	multiple	ADJ
bptjm-57	145	9	types	type	NOUN
bptjm-57	145	10	of	of	ADP
bptjm-57	145	11	treatment	treatment	NOUN
bptjm-57	145	12	.	.	PUNCT
bptjm-57	146	1	it	it	PRON
bptjm-57	146	2	can	can	AUX
bptjm-57	146	3	be	be	AUX
bptjm-57	146	4	a	a	DET
bptjm-57	146	5	combination	combination	NOUN
bptjm-57	146	6	of	of	ADP
bptjm-57	146	7	drugs	drug	NOUN
bptjm-57	146	8	,	,	PUNCT
bptjm-57	146	9	immunotherapies	immunotherapy	NOUN
bptjm-57	146	10	,	,	PUNCT
bptjm-57	146	11	chemotherapy	chemotherapy	NOUN
bptjm-57	146	12	,	,	PUNCT
bptjm-57	146	13	radiation	radiation	NOUN
bptjm-57	146	14	,	,	PUNCT
bptjm-57	146	15	and	and	CCONJ
bptjm-57	146	16	other	other	ADJ
bptjm-57	146	17	cancer	cancer	NOUN
bptjm-57	146	18	treatments	treatment	NOUN
bptjm-57	146	19	.	.	PUNCT
bptjm-57	147	1	since	since	SCONJ
bptjm-57	147	2	cells	cell	NOUN
bptjm-57	147	3	respond	respond	VERB
bptjm-57	147	4	to	to	ADP
bptjm-57	147	5	di	di	NOUN
bptjm-57	147	6	�	�	PROPN
bptjm-57	147	7	erent	erent	NOUN
bptjm-57	147	8	therapies	therapy	NOUN
bptjm-57	147	9	,	,	PUNCT
bptjm-57	147	10	a	a	DET
bptjm-57	147	11	highly	highly	ADV
bptjm-57	147	12	heterogeneous	heterogeneous	ADJ
bptjm-57	147	13	tumor	tumor	NOUN
bptjm-57	147	14	likely	likely	ADV
bptjm-57	147	15	needs	need	VERB
bptjm-57	147	16	multiple	multiple	ADJ
bptjm-57	147	17	treatments	treatment	NOUN
bptjm-57	147	18	in	in	ADP
bptjm-57	147	19	order	order	NOUN
bptjm-57	147	20	to	to	PART
bptjm-57	147	21	eliminate	eliminate	VERB
bptjm-57	147	22	berkeley	berkeley	PROPN
bptjm-57	147	23	pharma	pharma	PROPN
bptjm-57	147	24	tech	tech	NOUN
bptjm-57	147	25	journal	journal	NOUN
bptjm-57	147	26	of	of	ADP
bptjm-57	147	27	medicine	medicine	NOUN
bptjm-57	147	28	|	|	ADV
bptjm-57	147	29	98	98	NUM
bptjm-57	147	30	all	all	DET
bptjm-57	147	31	tumor	tumor	NOUN
bptjm-57	147	32	cells	cell	NOUN
bptjm-57	147	33	from	from	ADP
bptjm-57	147	34	the	the	DET
bptjm-57	147	35	body	body	NOUN
bptjm-57	147	36	.	.	PUNCT
bptjm-57	148	1	however	however	ADV
bptjm-57	148	2	,	,	PUNCT
bptjm-57	148	3	too	too	ADV
bptjm-57	148	4	many	many	ADJ
bptjm-57	148	5	drugs	drug	NOUN
bptjm-57	148	6	can	can	AUX
bptjm-57	148	7	strain	strain	VERB
bptjm-57	148	8	the	the	DET
bptjm-57	148	9	body	body	NOUN
bptjm-57	148	10	and	and	CCONJ
bptjm-57	148	11	be	be	AUX
bptjm-57	148	12	highly	highly	ADV
bptjm-57	148	13	toxic	toxic	ADJ
bptjm-57	148	14	.	.	PUNCT
bptjm-57	149	1	combination	combination	NOUN
bptjm-57	149	2	therapy	therapy	NOUN
bptjm-57	149	3	thus	thus	ADV
bptjm-57	149	4	seeks	seek	VERB
bptjm-57	149	5	to	to	PART
bptjm-57	149	6	maximize	maximize	VERB
bptjm-57	149	7	e	e	NOUN
bptjm-57	149	8	�	�	NOUN
bptjm-57	149	9	ciency	ciency	NOUN
bptjm-57	149	10	while	while	SCONJ
bptjm-57	149	11	minimizing	minimize	VERB
bptjm-57	149	12	toxicity	toxicity	NOUN
bptjm-57	149	13	.	.	PUNCT
bptjm-57	150	1	by	by	ADP
bptjm-57	150	2	using	use	VERB
bptjm-57	150	3	existing	exist	VERB
bptjm-57	150	4	treatments	treatment	NOUN
bptjm-57	150	5	,	,	PUNCT
bptjm-57	150	6	it	it	PRON
bptjm-57	150	7	can	can	AUX
bptjm-57	150	8	also	also	ADV
bptjm-57	150	9	be	be	AUX
bptjm-57	150	10	cheaper	cheap	ADJ
bptjm-57	150	11	and	and	CCONJ
bptjm-57	150	12	more	more	ADJ
bptjm-57	150	13	time	time	NOUN
bptjm-57	150	14	-	-	PUNCT
bptjm-57	150	15	e	e	NOUN
bptjm-57	150	16	�	�	NOUN
bptjm-57	150	17	ective	ective	ADJ
bptjm-57	150	18	to	to	ADP
bptjm-57	150	19	research	research	NOUN
bptjm-57	150	20	than	than	ADP
bptjm-57	150	21	developing	develop	VERB
bptjm-57	150	22	a	a	DET
bptjm-57	150	23	new	new	ADJ
bptjm-57	150	24	drug	drug	NOUN
bptjm-57	150	25	or	or	CCONJ
bptjm-57	150	26	treatment.59	treatment.59	VERB
bptjm-57	150	27	one	one	NUM
bptjm-57	150	28	study	study	NOUN
bptjm-57	150	29	on	on	ADP
bptjm-57	150	30	mice	mouse	NOUN
bptjm-57	150	31	,	,	PUNCT
bptjm-57	150	32	published	publish	VERB
bptjm-57	150	33	in	in	ADP
bptjm-57	150	34	2018	2018	NUM
bptjm-57	150	35	and	and	CCONJ
bptjm-57	150	36	funded	fund	VERB
bptjm-57	150	37	by	by	ADP
bptjm-57	150	38	the	the	DET
bptjm-57	150	39	canadian	canadian	ADJ
bptjm-57	150	40	cancer	cancer	NOUN
bptjm-57	150	41	society	society	NOUN
bptjm-57	150	42	,	,	PUNCT
bptjm-57	150	43	used	use	VERB
bptjm-57	150	44	oncolytic	oncolytic	ADJ
bptjm-57	150	45	viruses	virus	NOUN
bptjm-57	150	46	and	and	CCONJ
bptjm-57	150	47	the	the	DET
bptjm-57	150	48	hdac	hdac	NOUN
bptjm-57	150	49	inhibitor	inhibitor	PROPN
bptjm-57	150	50	ms-275	ms-275	PROPN
bptjm-57	150	51	to	to	PART
bptjm-57	150	52	prevent	prevent	VERB
bptjm-57	150	53	relapse	relapse	NOUN
bptjm-57	150	54	from	from	ADP
bptjm-57	150	55	act	act	PROPN
bptjm-57	150	56	.	.	PUNCT
bptjm-57	151	1	the	the	DET
bptjm-57	151	2	cd8	cd8	PROPN
bptjm-57	151	3	+	+	PROPN
bptjm-57	151	4	t	t	PROPN
bptjm-57	151	5	cells	cell	NOUN
bptjm-57	151	6	targeted	target	VERB
bptjm-57	151	7	a	a	DET
bptjm-57	151	8	speci	speci	ADJ
bptjm-57	151	9	�	�	PROPN
bptjm-57	151	10	c	c	NOUN
bptjm-57	151	11	antigen	antigen	NOUN
bptjm-57	151	12	on	on	ADP
bptjm-57	151	13	the	the	DET
bptjm-57	151	14	tumor	tumor	NOUN
bptjm-57	151	15	.	.	PUNCT
bptjm-57	152	1	with	with	ADP
bptjm-57	152	2	only	only	ADJ
bptjm-57	152	3	act	act	NOUN
bptjm-57	152	4	,	,	PUNCT
bptjm-57	152	5	there	there	PRON
bptjm-57	152	6	was	be	VERB
bptjm-57	152	7	a	a	DET
bptjm-57	152	8	signi	signi	ADJ
bptjm-57	152	9	�	�	NOUN
bptjm-57	152	10	cant	cant	NOUN
bptjm-57	152	11	improvement	improvement	NOUN
bptjm-57	152	12	in	in	ADP
bptjm-57	152	13	tumor	tumor	NOUN
bptjm-57	152	14	size	size	NOUN
bptjm-57	152	15	;	;	PUNCT
bptjm-57	152	16	however	however	ADV
bptjm-57	152	17	,	,	PUNCT
bptjm-57	152	18	selective	selective	ADJ
bptjm-57	152	19	pressure	pressure	NOUN
bptjm-57	152	20	had	have	AUX
bptjm-57	152	21	occurred	occur	VERB
bptjm-57	152	22	until	until	SCONJ
bptjm-57	152	23	only	only	ADV
bptjm-57	152	24	antigen	antigen	ADJ
bptjm-57	152	25	-	-	PUNCT
bptjm-57	152	26	negative	negative	ADJ
bptjm-57	152	27	tumor	tumor	NOUN
bptjm-57	152	28	cells	cell	NOUN
bptjm-57	152	29	were	be	AUX
bptjm-57	152	30	remaining	remain	VERB
bptjm-57	152	31	,	,	PUNCT
bptjm-57	152	32	signifying	signify	VERB
bptjm-57	152	33	that	that	SCONJ
bptjm-57	152	34	the	the	DET
bptjm-57	152	35	t	t	NOUN
bptjm-57	152	36	cells	cell	NOUN
bptjm-57	152	37	could	could	AUX
bptjm-57	152	38	no	no	ADV
bptjm-57	152	39	longer	long	ADV
bptjm-57	152	40	target	target	VERB
bptjm-57	152	41	those	those	DET
bptjm-57	152	42	tumor	tumor	NOUN
bptjm-57	152	43	cells	cell	NOUN
bptjm-57	152	44	.	.	PUNCT
bptjm-57	153	1	the	the	DET
bptjm-57	153	2	use	use	NOUN
bptjm-57	153	3	of	of	ADP
bptjm-57	153	4	oncolytic	oncolytic	ADJ
bptjm-57	153	5	viruses	virus	NOUN
bptjm-57	153	6	andms-275	andms-275	ADV
bptjm-57	153	7	was	be	AUX
bptjm-57	153	8	shown	show	VERB
bptjm-57	153	9	to	to	PART
bptjm-57	153	10	prevent	prevent	VERB
bptjm-57	153	11	any	any	DET
bptjm-57	153	12	relapse	relapse	NOUN
bptjm-57	153	13	and	and	CCONJ
bptjm-57	153	14	change	change	VERB
bptjm-57	153	15	tumor	tumor	NOUN
bptjm-57	153	16	-	-	PUNCT
bptjm-57	153	17	in	in	ADP
bptjm-57	153	18	�	�	NOUN
bptjm-57	153	19	ltrating	ltrate	VERB
bptjm-57	153	20	myeloid	myeloid	ADJ
bptjm-57	153	21	cells	cell	NOUN
bptjm-57	153	22	into	into	ADP
bptjm-57	153	23	pro	pro	ADJ
bptjm-57	153	24	-	-	ADJ
bptjm-57	153	25	in	in	ADP
bptjm-57	153	26	�	�	NOUN
bptjm-57	153	27	ammatory	ammatory	NOUN
bptjm-57	153	28	cells	cell	NOUN
bptjm-57	153	29	,	,	PUNCT
bptjm-57	153	30	allowing	allow	VERB
bptjm-57	153	31	for	for	ADP
bptjm-57	153	32	better	well	ADJ
bptjm-57	153	33	recovery.60	recovery.60	NOUN
bptjm-57	153	34	in	in	ADP
bptjm-57	153	35	a	a	DET
bptjm-57	153	36	phase	phase	NOUN
bptjm-57	153	37	ii	ii	NOUN
bptjm-57	153	38	clinical	clinical	ADJ
bptjm-57	153	39	trial	trial	NOUN
bptjm-57	153	40	funded	fund	VERB
bptjm-57	153	41	by	by	ADP
bptjm-57	153	42	bristol	bristol	PROPN
bptjm-57	153	43	myers	myers	PROPN
bptjm-57	153	44	squibb	squibb	PROPN
bptjm-57	153	45	that	that	PRON
bptjm-57	153	46	ended	end	VERB
bptjm-57	153	47	in	in	ADP
bptjm-57	153	48	2018	2018	NUM
bptjm-57	153	49	,	,	PUNCT
bptjm-57	153	50	researchers	researcher	NOUN
bptjm-57	153	51	found	find	VERB
bptjm-57	153	52	that	that	SCONJ
bptjm-57	153	53	patients	patient	NOUN
bptjm-57	153	54	with	with	ADP
bptjm-57	153	55	melanoma	melanoma	NOUN
bptjm-57	153	56	responded	respond	VERB
bptjm-57	153	57	favorably	favorably	ADV
bptjm-57	153	58	to	to	ADP
bptjm-57	153	59	a	a	DET
bptjm-57	153	60	combination	combination	NOUN
bptjm-57	153	61	of	of	ADP
bptjm-57	153	62	melphalan	melphalan	NOUN
bptjm-57	153	63	(	(	PUNCT
bptjm-57	153	64	chemotherapy	chemotherapy	NOUN
bptjm-57	153	65	)	)	PUNCT
bptjm-57	153	66	and	and	CCONJ
bptjm-57	153	67	the	the	DET
bptjm-57	153	68	approved	approve	VERB
bptjm-57	153	69	ctla-4	ctla-4	NUM
bptjm-57	153	70	blocker	blocker	NOUN
bptjm-57	153	71	ipilimumab	ipilimumab	NOUN
bptjm-57	153	72	(	(	PUNCT
bptjm-57	153	73	immunotherapy	immunotherapy	NOUN
bptjm-57	153	74	)	)	PUNCT
bptjm-57	153	75	.	.	PUNCT
bptjm-57	154	1	based	base	VERB
bptjm-57	154	2	on	on	ADP
bptjm-57	154	3	the	the	DET
bptjm-57	154	4	data	datum	NOUN
bptjm-57	154	5	provided	provide	VERB
bptjm-57	154	6	,	,	PUNCT
bptjm-57	154	7	85	85	NUM
bptjm-57	154	8	%	%	NOUN
bptjm-57	154	9	of	of	ADP
bptjm-57	154	10	patients	patient	NOUN
bptjm-57	154	11	had	have	VERB
bptjm-57	154	12	observable	observable	ADJ
bptjm-57	154	13	responses	response	NOUN
bptjm-57	154	14	to	to	ADP
bptjm-57	154	15	the	the	DET
bptjm-57	154	16	treatment	treatment	NOUN
bptjm-57	154	17	,	,	PUNCT
bptjm-57	154	18	and	and	CCONJ
bptjm-57	154	19	there	there	PRON
bptjm-57	154	20	was	be	VERB
bptjm-57	154	21	a	a	DET
bptjm-57	154	22	58	58	NUM
bptjm-57	154	23	%	%	NOUN
bptjm-57	154	24	progression	progression	NOUN
bptjm-57	154	25	-	-	PUNCT
bptjm-57	154	26	free	free	ADJ
bptjm-57	154	27	survival	survival	NOUN
bptjm-57	154	28	(	(	PUNCT
bptjm-57	154	29	pfs	pfs	PROPN
bptjm-57	154	30	)	)	PUNCT
bptjm-57	154	31	rate	rate	NOUN
bptjm-57	154	32	after	after	ADP
bptjm-57	154	33	one	one	NUM
bptjm-57	154	34	year	year	NOUN
bptjm-57	154	35	,	,	PUNCT
bptjm-57	154	36	with	with	SCONJ
bptjm-57	154	37	no	no	DET
bptjm-57	154	38	increase	increase	NOUN
bptjm-57	154	39	in	in	ADP
bptjm-57	154	40	toxicity	toxicity	NOUN
bptjm-57	154	41	at	at	ADP
bptjm-57	154	42	the	the	DET
bptjm-57	154	43	site	site	NOUN
bptjm-57	154	44	of	of	ADP
bptjm-57	154	45	the	the	DET
bptjm-57	154	46	treatment.61	treatment.61	NOUN
bptjm-57	154	47	an	an	DET
bptjm-57	154	48	ongoing	ongoing	ADJ
bptjm-57	154	49	clinical	clinical	ADJ
bptjm-57	154	50	trial	trial	NOUN
bptjm-57	154	51	(	(	PUNCT
bptjm-57	154	52	2018	2018	NUM
bptjm-57	154	53	-	-	SYM
bptjm-57	154	54	2024	2024	NUM
bptjm-57	154	55	estimate	estimate	NOUN
bptjm-57	154	56	)	)	PUNCT
bptjm-57	154	57	by	by	ADP
bptjm-57	154	58	medimmune	medimmune	PROPN
bptjm-57	154	59	llc	llc	PROPN
bptjm-57	154	60	is	be	AUX
bptjm-57	154	61	testing	test	VERB
bptjm-57	154	62	various	various	ADJ
bptjm-57	154	63	dosages	dosage	NOUN
bptjm-57	154	64	of	of	ADP
bptjm-57	154	65	oleclumab	oleclumab	NOUN
bptjm-57	154	66	and	and	CCONJ
bptjm-57	154	67	osimertinib	osimertinib	NOUN
bptjm-57	154	68	in	in	ADP
bptjm-57	154	69	the	the	DET
bptjm-57	154	70	treatment	treatment	NOUN
bptjm-57	154	71	of	of	ADP
bptjm-57	154	72	nsclc	nsclc	NOUN
bptjm-57	154	73	.	.	PUNCT
bptjm-57	155	1	the	the	DET
bptjm-57	155	2	percentage	percentage	NOUN
bptjm-57	155	3	of	of	ADP
bptjm-57	155	4	patients	patient	NOUN
bptjm-57	155	5	with	with	ADP
bptjm-57	155	6	disease	disease	NOUN
bptjm-57	155	7	control	control	NOUN
bptjm-57	155	8	(	(	PUNCT
bptjm-57	155	9	complete	complete	ADJ
bptjm-57	155	10	response	response	NOUN
bptjm-57	155	11	,	,	PUNCT
bptjm-57	155	12	partial	partial	ADJ
bptjm-57	155	13	response	response	NOUN
bptjm-57	155	14	,	,	PUNCT
bptjm-57	155	15	or	or	CCONJ
bptjm-57	155	16	stable	stable	ADJ
bptjm-57	155	17	)	)	PUNCT
bptjm-57	155	18	and	and	CCONJ
bptjm-57	155	19	overall	overall	ADJ
bptjm-57	155	20	survival	survival	NOUN
bptjm-57	155	21	for	for	ADP
bptjm-57	155	22	each	each	DET
bptjm-57	155	23	dose	dose	NOUN
bptjm-57	155	24	is	be	AUX
bptjm-57	155	25	as	as	SCONJ
bptjm-57	155	26	follows	follow	VERB
bptjm-57	155	27	:	:	PUNCT
bptjm-57	155	28	oleclumab	oleclumab	NOUN
bptjm-57	155	29	1	1	NUM
bptjm-57	156	1	+	+	NUM
bptjm-57	156	2	osimertinib	osimertinib	NOUN
bptjm-57	156	3	1	1	NUM
bptjm-57	156	4	:	:	SYM
bptjm-57	156	5	80	80	NUM
bptjm-57	156	6	%	%	NOUN
bptjm-57	156	7	,	,	PUNCT
bptjm-57	156	8	21.9	21.9	NUM
bptjm-57	156	9	months	month	NOUN
bptjm-57	156	10	oleclumab	oleclumab	VERB
bptjm-57	157	1	2	2	NUM
bptjm-57	157	2	+	+	NUM
bptjm-57	157	3	osimertinib	osimertinib	NOUN
bptjm-57	157	4	1	1	NUM
bptjm-57	157	5	:	:	SYM
bptjm-57	157	6	81	81	NUM
bptjm-57	157	7	%	%	NOUN
bptjm-57	157	8	,	,	PUNCT
bptjm-57	157	9	24.8	24.8	NUM
bptjm-57	157	10	months	month	NOUN
bptjm-57	157	11	none	none	NOUN
bptjm-57	157	12	of	of	ADP
bptjm-57	157	13	the	the	DET
bptjm-57	157	14	patients	patient	NOUN
bptjm-57	157	15	that	that	PRON
bptjm-57	157	16	received	receive	VERB
bptjm-57	157	17	the	the	DET
bptjm-57	157	18	above	above	ADJ
bptjm-57	157	19	doses	dose	NOUN
bptjm-57	157	20	had	have	VERB
bptjm-57	157	21	any	any	DET
bptjm-57	157	22	dose	dose	NOUN
bptjm-57	157	23	-	-	PUNCT
bptjm-57	157	24	limiting	limit	VERB
bptjm-57	157	25	toxicities	toxicity	NOUN
bptjm-57	157	26	within	within	ADP
bptjm-57	157	27	twenty	twenty	NUM
bptjm-57	157	28	-	-	PUNCT
bptjm-57	157	29	eight	eight	NUM
bptjm-57	157	30	days	day	NOUN
bptjm-57	157	31	of	of	ADP
bptjm-57	157	32	the	the	DET
bptjm-57	157	33	�	�	PROPN
bptjm-57	157	34	rst	rst	PROPN
bptjm-57	157	35	treatment	treatment	NOUN
bptjm-57	157	36	.	.	PUNCT
bptjm-57	158	1	however	however	ADV
bptjm-57	158	2	,	,	PUNCT
bptjm-57	158	3	within	within	ADP
bptjm-57	158	4	ninety	ninety	NUM
bptjm-57	158	5	days	day	NOUN
bptjm-57	158	6	of	of	ADP
bptjm-57	158	7	the	the	DET
bptjm-57	158	8	last	last	ADJ
bptjm-57	158	9	dose	dose	NOUN
bptjm-57	158	10	,	,	PUNCT
bptjm-57	158	11	all	all	DET
bptjm-57	158	12	patients	patient	NOUN
bptjm-57	158	13	had	have	VERB
bptjm-57	158	14	adverse	adverse	ADJ
bptjm-57	158	15	e	e	NOUN
bptjm-57	158	16	�	�	NOUN
bptjm-57	158	17	ects	ect	NOUN
bptjm-57	158	18	,	,	PUNCT
bptjm-57	158	19	such	such	ADJ
bptjm-57	158	20	as	as	ADP
bptjm-57	158	21	infections	infection	NOUN
bptjm-57	158	22	and	and	CCONJ
bptjm-57	158	23	infestations	infestation	NOUN
bptjm-57	158	24	like	like	ADP
bptjm-57	158	25	cystitis	cystitis	NOUN
bptjm-57	158	26	and	and	CCONJ
bptjm-57	158	27	pneumonia	pneumonia	NOUN
bptjm-57	158	28	,	,	PUNCT
bptjm-57	158	29	as	as	ADV
bptjm-57	158	30	well	well	ADV
bptjm-57	158	31	as	as	ADP
bptjm-57	158	32	nervous	nervous	ADJ
bptjm-57	158	33	system	system	NOUN
bptjm-57	158	34	disorders	disorder	NOUN
bptjm-57	158	35	like	like	ADP
bptjm-57	158	36	cerebral	cerebral	ADJ
bptjm-57	158	37	infarction	infarction	NOUN
bptjm-57	158	38	and	and	CCONJ
bptjm-57	158	39	spinal	spinal	ADJ
bptjm-57	158	40	cord	cord	NOUN
bptjm-57	158	41	compression	compression	NOUN
bptjm-57	158	42	.	.	PUNCT
bptjm-57	159	1	even	even	ADV
bptjm-57	159	2	so	so	ADV
bptjm-57	159	3	,	,	PUNCT
bptjm-57	159	4	only	only	ADV
bptjm-57	159	5	berkeley	berkeley	PROPN
bptjm-57	159	6	pharma	pharma	PROPN
bptjm-57	159	7	tech	tech	NOUN
bptjm-57	159	8	journal	journal	NOUN
bptjm-57	159	9	of	of	ADP
bptjm-57	159	10	medicine	medicine	NOUN
bptjm-57	159	11	|	|	ADV
bptjm-57	159	12	99	99	NUM
bptjm-57	159	13	one	one	NUM
bptjm-57	159	14	patient	patient	NOUN
bptjm-57	159	15	who	who	PRON
bptjm-57	159	16	received	receive	VERB
bptjm-57	159	17	the	the	DET
bptjm-57	159	18	oleclumab	oleclumab	NOUN
bptjm-57	159	19	1	1	NUM
bptjm-57	159	20	+	+	NUM
bptjm-57	159	21	osimertinib	osimertinib	NOUN
bptjm-57	159	22	1	1	NUM
bptjm-57	159	23	doses	dose	NOUN
bptjm-57	159	24	had	have	VERB
bptjm-57	159	25	abnormal	abnormal	ADJ
bptjm-57	159	26	vital	vital	ADJ
bptjm-57	159	27	signs	sign	NOUN
bptjm-57	159	28	that	that	PRON
bptjm-57	159	29	were	be	AUX
bptjm-57	159	30	considered	consider	VERB
bptjm-57	159	31	severe.62	severe.62	NOUN
bptjm-57	159	32	this	this	PRON
bptjm-57	159	33	shows	show	VERB
bptjm-57	159	34	the	the	DET
bptjm-57	159	35	importance	importance	NOUN
bptjm-57	159	36	of	of	ADP
bptjm-57	159	37	�	�	PROPN
bptjm-57	159	38	nding	nde	VERB
bptjm-57	159	39	the	the	DET
bptjm-57	159	40	right	right	ADJ
bptjm-57	159	41	amount	amount	NOUN
bptjm-57	159	42	of	of	ADP
bptjm-57	159	43	dose	dose	NOUN
bptjm-57	159	44	to	to	PART
bptjm-57	159	45	give	give	VERB
bptjm-57	159	46	to	to	ADP
bptjm-57	159	47	the	the	DET
bptjm-57	159	48	patient	patient	NOUN
bptjm-57	159	49	,	,	PUNCT
bptjm-57	159	50	especially	especially	ADV
bptjm-57	159	51	in	in	ADP
bptjm-57	159	52	the	the	DET
bptjm-57	159	53	case	case	NOUN
bptjm-57	159	54	of	of	ADP
bptjm-57	159	55	combination	combination	NOUN
bptjm-57	159	56	therapy	therapy	NOUN
bptjm-57	159	57	.	.	PUNCT
bptjm-57	160	1	3.3	3.3	NUM
bptjm-57	160	2	dual	dual	ADJ
bptjm-57	160	3	/	/	SYM
bptjm-57	160	4	multi	multi	X
bptjm-57	160	5	ex	ex	X
bptjm-57	160	6	vivo	vivo	ADJ
bptjm-57	160	7	armed	armed	ADJ
bptjm-57	160	8	t	t	PROPN
bptjm-57	160	9	cells	cell	NOUN
bptjm-57	160	10	(	(	PUNCT
bptjm-57	160	11	eats	eat	NOUN
bptjm-57	160	12	)	)	PUNCT
bptjm-57	160	13	dualor	dualor	NOUN
bptjm-57	160	14	multi	multi	NOUN
bptjm-57	160	15	-	-	ADJ
bptjm-57	160	16	eats	eat	NOUN
bptjm-57	160	17	are	be	AUX
bptjm-57	160	18	t	t	NOUN
bptjm-57	160	19	cells	cell	NOUN
bptjm-57	160	20	armed	arm	VERB
bptjm-57	160	21	with	with	ADP
bptjm-57	160	22	two	two	NUM
bptjm-57	160	23	or	or	CCONJ
bptjm-57	160	24	more	more	ADJ
bptjm-57	160	25	bispeci	bispeci	PROPN
bptjm-57	160	26	�	�	PROPN
bptjm-57	160	27	c	c	PROPN
bptjm-57	160	28	antibodies	antibodie	VERB
bptjm-57	160	29	(	(	PUNCT
bptjm-57	160	30	bsabs	bsab	NOUN
bptjm-57	160	31	)	)	PUNCT
bptjm-57	160	32	.	.	PUNCT
bptjm-57	161	1	generally	generally	ADV
bptjm-57	161	2	,	,	PUNCT
bptjm-57	161	3	t	t	NOUN
bptjm-57	161	4	-	-	PUNCT
bptjm-57	161	5	cell	cell	NOUN
bptjm-57	161	6	-	-	PUNCT
bptjm-57	161	7	engaging	engage	VERB
bptjm-57	161	8	bispeci	bispeci	PROPN
bptjm-57	161	9	�	�	PROPN
bptjm-57	161	10	c	c	PROPN
bptjm-57	161	11	antibodies	antibodie	VERB
bptjm-57	161	12	(	(	PUNCT
bptjm-57	161	13	t	t	NOUN
bptjm-57	161	14	-	-	PUNCT
bptjm-57	161	15	bsabs	bsab	NOUN
bptjm-57	161	16	)	)	PUNCT
bptjm-57	161	17	bind	bind	VERB
bptjm-57	161	18	speci	speci	NOUN
bptjm-57	161	19	�	�	PROPN
bptjm-57	161	20	cally	cally	ADV
bptjm-57	161	21	to	to	ADP
bptjm-57	161	22	a	a	DET
bptjm-57	161	23	tumor	tumor	NOUN
bptjm-57	161	24	-	-	PUNCT
bptjm-57	161	25	associated	associate	VERB
bptjm-57	161	26	antigen	antigen	X
bptjm-57	161	27	(	(	PUNCT
bptjm-57	161	28	taa	taa	X
bptjm-57	161	29	)	)	PUNCT
bptjm-57	161	30	and	and	CCONJ
bptjm-57	161	31	a	a	DET
bptjm-57	161	32	cd3	cd3	ADJ
bptjm-57	161	33	subunit	subunit	NOUN
bptjm-57	161	34	that	that	PRON
bptjm-57	161	35	forms	form	VERB
bptjm-57	161	36	a	a	DET
bptjm-57	161	37	complex	complex	NOUN
bptjm-57	161	38	with	with	ADP
bptjm-57	161	39	the	the	DET
bptjm-57	161	40	tumor	tumor	NOUN
bptjm-57	161	41	cell	cell	NOUN
bptjm-57	161	42	receptor	receptor	NOUN
bptjm-57	161	43	(	(	PUNCT
bptjm-57	161	44	tcr	tcr	PROPN
bptjm-57	161	45	)	)	PUNCT
bptjm-57	161	46	.	.	PUNCT
bptjm-57	162	1	t	t	PROPN
bptjm-57	162	2	-	-	PUNCT
bptjm-57	162	3	bsabs	bsab	NOUN
bptjm-57	162	4	can	can	AUX
bptjm-57	162	5	thus	thus	ADV
bptjm-57	162	6	link	link	VERB
bptjm-57	162	7	tumor	tumor	NOUN
bptjm-57	162	8	cells	cell	NOUN
bptjm-57	162	9	and	and	CCONJ
bptjm-57	162	10	t	t	NOUN
bptjm-57	162	11	cells	cell	NOUN
bptjm-57	162	12	together	together	ADV
bptjm-57	162	13	,	,	PUNCT
bptjm-57	162	14	activating	activate	VERB
bptjm-57	162	15	t	t	NOUN
bptjm-57	162	16	cells	cell	NOUN
bptjm-57	162	17	and	and	CCONJ
bptjm-57	162	18	leading	lead	VERB
bptjm-57	162	19	to	to	ADP
bptjm-57	162	20	tumor	tumor	NOUN
bptjm-57	162	21	death	death	NOUN
bptjm-57	162	22	.	.	PUNCT
bptjm-57	163	1	moreover	moreover	ADV
bptjm-57	163	2	,	,	PUNCT
bptjm-57	163	3	cd3	cd3	PROPN
bptjm-57	163	4	engagement	engagement	PROPN
bptjm-57	163	5	stimulates	stimulate	VERB
bptjm-57	163	6	the	the	DET
bptjm-57	163	7	t	t	PROPN
bptjm-57	163	8	cells	cell	NOUN
bptjm-57	163	9	’	’	PART
bptjm-57	163	10	immune	immune	ADJ
bptjm-57	163	11	response	response	NOUN
bptjm-57	163	12	,	,	PUNCT
bptjm-57	163	13	which	which	PRON
bptjm-57	163	14	redirects	redirect	VERB
bptjm-57	163	15	host	host	NOUN
bptjm-57	163	16	immunity	immunity	NOUN
bptjm-57	163	17	toward	toward	ADP
bptjm-57	163	18	tumors	tumor	NOUN
bptjm-57	163	19	.	.	PUNCT
bptjm-57	164	1	hence	hence	ADV
bptjm-57	164	2	,	,	PUNCT
bptjm-57	164	3	t	t	PROPN
bptjm-57	164	4	-	-	PUNCT
bptjm-57	164	5	bsabs	bsab	NOUN
bptjm-57	164	6	are	be	AUX
bptjm-57	164	7	a	a	DET
bptjm-57	164	8	promising	promising	ADJ
bptjm-57	164	9	antibody	antibody	NOUN
bptjm-57	164	10	therapy	therapy	NOUN
bptjm-57	164	11	for	for	ADP
bptjm-57	164	12	various	various	ADJ
bptjm-57	164	13	cancers.64a	cancers.64a	NOUN
bptjm-57	164	14	phase	phase	NOUN
bptjm-57	164	15	i	i	PROPN
bptjm-57	164	16	/	/	SYM
bptjm-57	164	17	ii	ii	PROPN
bptjm-57	164	18	clinical	clinical	ADJ
bptjm-57	164	19	trial	trial	NOUN
bptjm-57	164	20	was	be	AUX
bptjm-57	164	21	conducted	conduct	VERB
bptjm-57	164	22	on	on	ADP
bptjm-57	164	23	epcoritamab	epcoritamab	NOUN
bptjm-57	164	24	,	,	PUNCT
bptjm-57	164	25	a	a	DET
bptjm-57	164	26	t	t	NOUN
bptjm-57	164	27	-	-	PUNCT
bptjm-57	164	28	bsab	bsab	NOUN
bptjm-57	164	29	that	that	PRON
bptjm-57	164	30	targets	target	VERB
bptjm-57	164	31	cd3	cd3	NOUN
bptjm-57	164	32	and	and	CCONJ
bptjm-57	164	33	cd20	cd20	PROPN
bptjm-57	164	34	.	.	PUNCT
bptjm-57	165	1	this	this	PRON
bptjm-57	165	2	targeting	target	VERB
bptjm-57	165	3	redirects	redirect	NOUN
bptjm-57	165	4	and	and	CCONJ
bptjm-57	165	5	activates	activate	VERB
bptjm-57	165	6	t	t	PROPN
bptjm-57	165	7	cells	cell	NOUN
bptjm-57	165	8	to	to	PART
bptjm-57	165	9	kill	kill	VERB
bptjm-57	165	10	cd20	cd20	PROPN
bptjm-57	165	11	-	-	PUNCT
bptjm-57	165	12	expressing	express	VERB
bptjm-57	165	13	malignant	malignant	ADJ
bptjm-57	165	14	cells	cell	NOUN
bptjm-57	165	15	in	in	ADP
bptjm-57	165	16	relapsed	relapse	VERB
bptjm-57	165	17	or	or	CCONJ
bptjm-57	165	18	refractory	refractory	NOUN
bptjm-57	165	19	large	large	ADJ
bptjm-57	165	20	b	b	NOUN
bptjm-57	165	21	-	-	PUNCT
bptjm-57	165	22	cell	cell	NOUN
bptjm-57	165	23	lymphoma	lymphoma	NOUN
bptjm-57	165	24	(	(	PUNCT
bptjm-57	165	25	lbcl	lbcl	NOUN
bptjm-57	165	26	)	)	PUNCT
bptjm-57	165	27	.	.	PUNCT
bptjm-57	166	1	among	among	ADP
bptjm-57	166	2	157	157	NUM
bptjm-57	166	3	patients	patient	NOUN
bptjm-57	166	4	,	,	PUNCT
bptjm-57	166	5	the	the	DET
bptjm-57	166	6	overall	overall	ADJ
bptjm-57	166	7	response	response	NOUN
bptjm-57	166	8	rate	rate	NOUN
bptjm-57	166	9	(	(	PUNCT
bptjm-57	166	10	orr	orr	PROPN
bptjm-57	166	11	)	)	PUNCT
bptjm-57	166	12	,	,	PUNCT
bptjm-57	166	13	de	de	PROPN
bptjm-57	166	14	�	�	NOUN
bptjm-57	166	15	ned	ne	VERB
bptjm-57	166	16	as	as	ADP
bptjm-57	166	17	the	the	DET
bptjm-57	166	18	proportion	proportion	NOUN
bptjm-57	166	19	of	of	ADP
bptjm-57	166	20	patients	patient	NOUN
bptjm-57	166	21	who	who	PRON
bptjm-57	166	22	have	have	VERB
bptjm-57	166	23	a	a	DET
bptjm-57	166	24	partial	partial	ADJ
bptjm-57	166	25	or	or	CCONJ
bptjm-57	166	26	complete	complete	ADJ
bptjm-57	166	27	response	response	NOUN
bptjm-57	166	28	to	to	ADP
bptjm-57	166	29	therapy	therapy	NOUN
bptjm-57	166	30	,	,	PUNCT
bptjm-57	166	31	was	be	AUX
bptjm-57	166	32	found	find	VERB
bptjm-57	166	33	to	to	PART
bptjm-57	166	34	be	be	AUX
bptjm-57	166	35	63.1%.64an	63.1%.64an	NUM
bptjm-57	166	36	orr	orr	NOUN
bptjm-57	166	37	value	value	NOUN
bptjm-57	166	38	greater	great	ADJ
bptjm-57	166	39	than	than	ADP
bptjm-57	166	40	60	60	NUM
bptjm-57	166	41	%	%	NOUN
bptjm-57	166	42	is	be	AUX
bptjm-57	166	43	grade	grade	NOUN
bptjm-57	166	44	3	3	NUM
bptjm-57	166	45	and	and	CCONJ
bptjm-57	166	46	is	be	AUX
bptjm-57	166	47	considered	consider	VERB
bptjm-57	166	48	a	a	DET
bptjm-57	166	49	high	high	ADJ
bptjm-57	166	50	value	value	NOUN
bptjm-57	166	51	,	,	PUNCT
bptjm-57	166	52	showing	show	VERB
bptjm-57	166	53	the	the	DET
bptjm-57	166	54	high	high	ADJ
bptjm-57	166	55	e	e	NOUN
bptjm-57	166	56	�	�	NOUN
bptjm-57	166	57	cacy	cacy	NOUN
bptjm-57	166	58	of	of	ADP
bptjm-57	166	59	epcoritamab.65	epcoritamab.65	ADP
bptjm-57	166	60	the	the	DET
bptjm-57	166	61	complete	complete	ADJ
bptjm-57	166	62	response	response	NOUN
bptjm-57	166	63	(	(	PUNCT
bptjm-57	166	64	cr	cr	NOUN
bptjm-57	166	65	)	)	PUNCT
bptjm-57	166	66	rate	rate	NOUN
bptjm-57	166	67	was	be	AUX
bptjm-57	166	68	38.9	38.9	NUM
bptjm-57	166	69	%	%	NOUN
bptjm-57	166	70	,	,	PUNCT
bptjm-57	166	71	with	with	ADP
bptjm-57	166	72	the	the	DET
bptjm-57	166	73	median	median	ADJ
bptjm-57	166	74	time	time	NOUN
bptjm-57	166	75	to	to	ADP
bptjm-57	166	76	cr	cr	NOUN
bptjm-57	166	77	being	be	AUX
bptjm-57	166	78	2.7	2.7	NUM
bptjm-57	166	79	months	month	NOUN
bptjm-57	166	80	.	.	PUNCT
bptjm-57	167	1	responses	response	NOUN
bptjm-57	167	2	with	with	ADP
bptjm-57	167	3	epcoritamab	epcoritamab	NOUN
bptjm-57	167	4	were	be	AUX
bptjm-57	167	5	also	also	ADV
bptjm-57	167	6	shown	show	VERB
bptjm-57	167	7	to	to	PART
bptjm-57	167	8	have	have	AUX
bptjm-57	167	9	transitioned	transition	VERB
bptjm-57	167	10	from	from	ADP
bptjm-57	167	11	partial	partial	ADJ
bptjm-57	167	12	response	response	NOUN
bptjm-57	167	13	(	(	PUNCT
bptjm-57	167	14	pr	pr	NOUN
bptjm-57	167	15	)	)	PUNCT
bptjm-57	167	16	to	to	ADP
bptjm-57	167	17	cr	cr	NOUN
bptjm-57	167	18	at	at	ADP
bptjm-57	167	19	the	the	DET
bptjm-57	167	20	later	later	ADJ
bptjm-57	167	21	assessments	assessment	NOUN
bptjm-57	167	22	in	in	ADP
bptjm-57	167	23	nine	nine	NUM
bptjm-57	167	24	patients	patient	NOUN
bptjm-57	167	25	.	.	PUNCT
bptjm-57	168	1	these	these	DET
bptjm-57	168	2	results	result	NOUN
bptjm-57	168	3	suggest	suggest	VERB
bptjm-57	168	4	there	there	PRON
bptjm-57	168	5	is	be	VERB
bptjm-57	168	6	an	an	DET
bptjm-57	168	7	added	add	VERB
bptjm-57	168	8	bene	bene	NOUN
bptjm-57	168	9	�	�	PROPN
bptjm-57	168	10	t	t	PROPN
bptjm-57	168	11	in	in	ADP
bptjm-57	168	12	certain	certain	ADJ
bptjm-57	168	13	patients	patient	NOUN
bptjm-57	168	14	with	with	ADP
bptjm-57	168	15	continuous	continuous	ADJ
bptjm-57	168	16	treatment	treatment	NOUN
bptjm-57	168	17	using	use	VERB
bptjm-57	168	18	this	this	DET
bptjm-57	168	19	t	t	PROPN
bptjm-57	168	20	-	-	PUNCT
bptjm-57	168	21	bsab.64another	bsab.64another	PROPN
bptjm-57	168	22	clinical	clinical	ADJ
bptjm-57	168	23	trial	trial	NOUN
bptjm-57	168	24	found	find	VERB
bptjm-57	168	25	that	that	SCONJ
bptjm-57	168	26	abbv-383	abbv-383	NOUN
bptjm-57	168	27	,	,	PUNCT
bptjm-57	168	28	a	a	DET
bptjm-57	168	29	b	b	NOUN
bptjm-57	168	30	-	-	PUNCT
bptjm-57	168	31	cell	cell	NOUN
bptjm-57	168	32	maturation	maturation	NOUN
bptjm-57	168	33	antigen	antigen	ADV
bptjm-57	168	34	x	x	PUNCT
bptjm-57	168	35	cd3	cd3	PROPN
bptjm-57	168	36	t	t	PROPN
bptjm-57	168	37	-	-	PUNCT
bptjm-57	168	38	bsab	bsab	NOUN
bptjm-57	168	39	,	,	PUNCT
bptjm-57	168	40	could	could	AUX
bptjm-57	168	41	treat	treat	VERB
bptjm-57	168	42	patients	patient	NOUN
bptjm-57	168	43	with	with	ADP
bptjm-57	168	44	relapsed	relapse	VERB
bptjm-57	168	45	or	or	CCONJ
bptjm-57	168	46	refractory	refractory	NOUN
bptjm-57	168	47	multiple	multiple	ADJ
bptjm-57	168	48	myeloma	myeloma	NOUN
bptjm-57	168	49	with	with	ADP
bptjm-57	168	50	an	an	DET
bptjm-57	168	51	orr	orr	NOUN
bptjm-57	168	52	of	of	ADP
bptjm-57	168	53	68	68	NUM
bptjm-57	168	54	%	%	NOUN
bptjm-57	168	55	at	at	ADP
bptjm-57	168	56	≥	≥	NOUN
bptjm-57	168	57	40	40	NUM
bptjm-57	168	58	mg	mg	ADP
bptjm-57	168	59	dosage	dosage	NOUN
bptjm-57	168	60	,	,	PUNCT
bptjm-57	168	61	showing	show	VERB
bptjm-57	168	62	the	the	DET
bptjm-57	168	63	t	t	PROPN
bptjm-57	168	64	-	-	PUNCT
bptjm-57	168	65	bsab	bsab	NOUN
bptjm-57	168	66	’s	’s	PART
bptjm-57	168	67	promise	promise	NOUN
bptjm-57	168	68	in	in	ADP
bptjm-57	168	69	treating	treat	VERB
bptjm-57	168	70	already	already	ADV
bptjm-57	168	71	heavily	heavily	ADV
bptjm-57	168	72	-	-	PUNCT
bptjm-57	168	73	treated	treat	VERB
bptjm-57	168	74	patients	patient	NOUN
bptjm-57	168	75	at	at	ADP
bptjm-57	168	76	that	that	DET
bptjm-57	168	77	dosage	dosage	NOUN
bptjm-57	168	78	amount.66	amount.66	NOUN
bptjm-57	168	79	eats	eat	NOUN
bptjm-57	168	80	are	be	AUX
bptjm-57	168	81	similar	similar	ADJ
bptjm-57	168	82	to	to	ADP
bptjm-57	168	83	t	t	PROPN
bptjm-57	168	84	-	-	PUNCT
bptjm-57	168	85	bsabs	bsab	NOUN
bptjm-57	168	86	in	in	SCONJ
bptjm-57	168	87	that	that	SCONJ
bptjm-57	168	88	they	they	PRON
bptjm-57	168	89	are	be	AUX
bptjm-57	168	90	also	also	ADV
bptjm-57	168	91	able	able	ADJ
bptjm-57	168	92	to	to	PART
bptjm-57	168	93	crosslink	crosslink	VERB
bptjm-57	168	94	tumor	tumor	NOUN
bptjm-57	168	95	cells	cell	NOUN
bptjm-57	168	96	and	and	CCONJ
bptjm-57	168	97	t	t	NOUN
bptjm-57	168	98	cells	cell	NOUN
bptjm-57	168	99	together	together	ADV
bptjm-57	168	100	,	,	PUNCT
bptjm-57	168	101	activating	activate	VERB
bptjm-57	168	102	the	the	DET
bptjm-57	168	103	subsequent	subsequent	ADJ
bptjm-57	168	104	immune	immune	ADJ
bptjm-57	168	105	response	response	NOUN
bptjm-57	168	106	.	.	PUNCT
bptjm-57	169	1	however	however	ADV
bptjm-57	169	2	,	,	PUNCT
bptjm-57	169	3	in	in	ADP
bptjm-57	169	4	eats	eat	NOUN
bptjm-57	169	5	,	,	PUNCT
bptjm-57	169	6	the	the	DET
bptjm-57	169	7	bsabs	bsab	NOUN
bptjm-57	169	8	are	be	AUX
bptjm-57	169	9	already	already	ADV
bptjm-57	169	10	attached	attach	VERB
bptjm-57	169	11	to	to	ADP
bptjm-57	169	12	the	the	DET
bptjm-57	169	13	t	t	NOUN
bptjm-57	169	14	cells	cell	NOUN
bptjm-57	169	15	,	,	PUNCT
bptjm-57	169	16	which	which	PRON
bptjm-57	169	17	makes	make	VERB
bptjm-57	169	18	them	they	PRON
bptjm-57	169	19	similar	similar	ADJ
bptjm-57	169	20	to	to	ADP
bptjm-57	169	21	car	car	NOUN
bptjm-57	169	22	-	-	PUNCT
bptjm-57	169	23	t	t	NOUN
bptjm-57	169	24	cell	cell	NOUN
bptjm-57	169	25	therapy	therapy	NOUN
bptjm-57	169	26	.	.	PUNCT
bptjm-57	170	1	the	the	DET
bptjm-57	170	2	only	only	ADJ
bptjm-57	170	3	di	di	PROPN
bptjm-57	170	4	�	�	PROPN
bptjm-57	170	5	erence	erence	NOUN
bptjm-57	170	6	is	be	AUX
bptjm-57	170	7	that	that	SCONJ
bptjm-57	170	8	they	they	PRON
bptjm-57	170	9	berkeley	berkeley	PROPN
bptjm-57	170	10	pharma	pharma	PROPN
bptjm-57	170	11	tech	tech	NOUN
bptjm-57	170	12	journal	journal	NOUN
bptjm-57	170	13	of	of	ADP
bptjm-57	170	14	medicine	medicine	NOUN
bptjm-57	170	15	|	|	ADV
bptjm-57	170	16	100	100	NUM
bptjm-57	170	17	are	be	AUX
bptjm-57	170	18	armed	arm	VERB
bptjm-57	170	19	with	with	ADP
bptjm-57	170	20	bsabs	bsab	NOUN
bptjm-57	170	21	instead	instead	ADV
bptjm-57	170	22	of	of	ADP
bptjm-57	170	23	cars	car	NOUN
bptjm-57	170	24	.	.	PUNCT
bptjm-57	171	1	with	with	ADP
bptjm-57	171	2	multiple	multiple	ADJ
bptjm-57	171	3	bsabs	bsab	NOUN
bptjm-57	171	4	attached	attach	VERB
bptjm-57	171	5	,	,	PUNCT
bptjm-57	171	6	dualor	dualor	NOUN
bptjm-57	171	7	multi	multi	NOUN
bptjm-57	171	8	-	-	ADJ
bptjm-57	171	9	eats	eat	NOUN
bptjm-57	171	10	can	can	AUX
bptjm-57	171	11	target	target	VERB
bptjm-57	171	12	a	a	DET
bptjm-57	171	13	wider	wide	ADJ
bptjm-57	171	14	variety	variety	NOUN
bptjm-57	171	15	of	of	ADP
bptjm-57	171	16	taas	taas	NOUN
bptjm-57	171	17	,	,	PUNCT
bptjm-57	171	18	thus	thus	ADV
bptjm-57	171	19	helping	help	VERB
bptjm-57	171	20	to	to	PART
bptjm-57	171	21	overcome	overcome	VERB
bptjm-57	171	22	tumor	tumor	NOUN
bptjm-57	171	23	heterogeneity	heterogeneity	NOUN
bptjm-57	171	24	.	.	PUNCT
bptjm-57	172	1	a	a	DET
bptjm-57	172	2	study	study	NOUN
bptjm-57	172	3	by	by	ADP
bptjm-57	172	4	park	park	NOUN
bptjm-57	172	5	and	and	CCONJ
bptjm-57	172	6	cheung	cheung	PROPN
bptjm-57	172	7	tested	test	VERB
bptjm-57	172	8	the	the	DET
bptjm-57	172	9	e	e	PROPN
bptjm-57	172	10	�	�	PROPN
bptjm-57	172	11	cacy	cacy	NOUN
bptjm-57	172	12	of	of	ADP
bptjm-57	172	13	dual	dual	ADJ
bptjm-57	172	14	-	-	PUNCT
bptjm-57	172	15	antigen	antigen	NOUN
bptjm-57	172	16	targeting	targeting	NOUN
bptjm-57	172	17	strategies	strategy	NOUN
bptjm-57	172	18	using	use	VERB
bptjm-57	172	19	di	di	NOUN
bptjm-57	172	20	�	�	PROPN
bptjm-57	172	21	erent	erent	NOUN
bptjm-57	172	22	kinds	kind	NOUN
bptjm-57	172	23	of	of	ADP
bptjm-57	172	24	eats	eat	NOUN
bptjm-57	172	25	,	,	PUNCT
bptjm-57	172	26	including	include	VERB
bptjm-57	172	27	pooled	pool	VERB
bptjm-57	172	28	-	-	PUNCT
bptjm-57	172	29	eats	eat	NOUN
bptjm-57	172	30	(	(	PUNCT
bptjm-57	172	31	eats	eat	VERB
bptjm-57	172	32	with	with	ADP
bptjm-57	172	33	unique	unique	ADJ
bptjm-57	172	34	speci	speci	ADJ
bptjm-57	172	35	�	�	PROPN
bptjm-57	172	36	city	city	NOUN
bptjm-57	172	37	administered	administer	VERB
bptjm-57	172	38	simultaneously	simultaneously	ADV
bptjm-57	172	39	)	)	PUNCT
bptjm-57	172	40	,	,	PUNCT
bptjm-57	172	41	alternate	alternate	NOUN
bptjm-57	172	42	-	-	PUNCT
bptjm-57	172	43	eats	eat	NOUN
bptjm-57	172	44	(	(	PUNCT
bptjm-57	172	45	eats	eat	VERB
bptjm-57	172	46	with	with	ADP
bptjm-57	172	47	unique	unique	ADJ
bptjm-57	172	48	speci	speci	ADJ
bptjm-57	172	49	�	�	PROPN
bptjm-57	172	50	city	city	NOUN
bptjm-57	172	51	administered	administer	VERB
bptjm-57	172	52	in	in	ADP
bptjm-57	172	53	an	an	DET
bptjm-57	172	54	alternating	alternate	VERB
bptjm-57	172	55	schedule	schedule	NOUN
bptjm-57	172	56	)	)	PUNCT
bptjm-57	172	57	,	,	PUNCT
bptjm-57	172	58	dual	dual	ADJ
bptjm-57	172	59	-	-	PUNCT
bptjm-57	172	60	eats	eat	NOUN
bptjm-57	172	61	,	,	PUNCT
bptjm-57	172	62	triab	triab	NOUN
bptjm-57	172	63	-	-	PUNCT
bptjm-57	172	64	eats	eat	NOUN
bptjm-57	172	65	(	(	PUNCT
bptjm-57	172	66	t	t	NOUN
bptjm-57	172	67	cells	cell	NOUN
bptjm-57	172	68	armed	arm	VERB
bptjm-57	172	69	with	with	ADP
bptjm-57	172	70	a	a	DET
bptjm-57	172	71	bsab	bsab	NOUN
bptjm-57	172	72	speci	speci	PROPN
bptjm-57	172	73	�	�	PROPN
bptjm-57	172	74	c	c	PROPN
bptjm-57	172	75	for	for	ADP
bptjm-57	172	76	two	two	NUM
bptjm-57	172	77	targets	target	NOUN
bptjm-57	172	78	besides	besides	SCONJ
bptjm-57	172	79	cd3	cd3	VERB
bptjm-57	172	80	)	)	PUNCT
bptjm-57	172	81	,	,	PUNCT
bptjm-57	172	82	and	and	CCONJ
bptjm-57	172	83	multi	multi	NOUN
bptjm-57	172	84	-	-	ADJ
bptjm-57	172	85	eats	eat	NOUN
bptjm-57	172	86	,	,	PUNCT
bptjm-57	172	87	with	with	ADP
bptjm-57	172	88	gd2	gd2	NOUN
bptjm-57	172	89	and	and	CCONJ
bptjm-57	172	90	her2	her2	VERB
bptjm-57	172	91	as	as	ADP
bptjm-57	172	92	target	target	NOUN
bptjm-57	172	93	antigens	antigen	NOUN
bptjm-57	172	94	.	.	PUNCT
bptjm-57	173	1	among	among	ADP
bptjm-57	173	2	these	these	PRON
bptjm-57	173	3	,	,	PUNCT
bptjm-57	173	4	they	they	PRON
bptjm-57	173	5	found	find	VERB
bptjm-57	173	6	that	that	SCONJ
bptjm-57	173	7	dualand	dualand	NOUN
bptjm-57	173	8	multi	multi	ADJ
bptjm-57	173	9	-	-	ADJ
bptjm-57	173	10	eats	eat	NOUN
bptjm-57	173	11	had	have	VERB
bptjm-57	173	12	the	the	DET
bptjm-57	173	13	most	most	ADV
bptjm-57	173	14	potential	potential	NOUN
bptjm-57	173	15	in	in	ADP
bptjm-57	173	16	overcoming	overcome	VERB
bptjm-57	173	17	tumor	tumor	NOUN
bptjm-57	173	18	heterogeneity	heterogeneity	NOUN
bptjm-57	173	19	and	and	CCONJ
bptjm-57	173	20	target	target	VERB
bptjm-57	173	21	antigen	antigen	ADJ
bptjm-57	173	22	loss	loss	NOUN
bptjm-57	173	23	,	,	PUNCT
bptjm-57	173	24	both	both	PRON
bptjm-57	173	25	of	of	ADP
bptjm-57	173	26	which	which	PRON
bptjm-57	173	27	are	be	AUX
bptjm-57	173	28	challenges	challenge	NOUN
bptjm-57	173	29	to	to	PART
bptjm-57	173	30	current	current	ADJ
bptjm-57	173	31	t	t	NOUN
bptjm-57	173	32	cell	cell	NOUN
bptjm-57	173	33	immunotherapies	immunotherapy	NOUN
bptjm-57	173	34	.	.	PUNCT
bptjm-57	174	1	dual	dual	ADJ
bptjm-57	174	2	-	-	PUNCT
bptjm-57	174	3	eats	eat	NOUN
bptjm-57	174	4	,	,	PUNCT
bptjm-57	174	5	armed	arm	VERB
bptjm-57	174	6	with	with	ADP
bptjm-57	174	7	gd2and	gd2and	PROPN
bptjm-57	174	8	her2	her2	PROPN
bptjm-57	174	9	-	-	PUNCT
bptjm-57	174	10	bsabs	bsab	NOUN
bptjm-57	174	11	,	,	PUNCT
bptjm-57	174	12	and	and	CCONJ
bptjm-57	174	13	multi	multi	NOUN
bptjm-57	174	14	-	-	ADJ
bptjm-57	174	15	eats	eat	NOUN
bptjm-57	174	16	,	,	PUNCT
bptjm-57	174	17	armed	arm	VERB
bptjm-57	174	18	with	with	ADP
bptjm-57	174	19	gd2-	gd2-	PROPN
bptjm-57	174	20	,	,	PUNCT
bptjm-57	174	21	her2-	her2-	PROPN
bptjm-57	174	22	,	,	PUNCT
bptjm-57	174	23	cd33-	cd33-	NOUN
bptjm-57	174	24	,	,	PUNCT
bptjm-57	174	25	psma-	psma-	X
bptjm-57	174	26	,	,	PUNCT
bptjm-57	174	27	and	and	CCONJ
bptjm-57	174	28	steap1	steap1	NOUN
bptjm-57	174	29	-	-	PUNCT
bptjm-57	174	30	bsabs	bsab	NOUN
bptjm-57	174	31	,	,	PUNCT
bptjm-57	174	32	had	have	AUX
bptjm-57	174	33	induced	induce	VERB
bptjm-57	174	34	stronger	strong	ADJ
bptjm-57	174	35	cytotoxicity	cytotoxicity	NOUN
bptjm-57	174	36	against	against	ADP
bptjm-57	174	37	a	a	DET
bptjm-57	174	38	mixed	mixed	ADJ
bptjm-57	174	39	lineage	lineage	NOUN
bptjm-57	174	40	of	of	ADP
bptjm-57	174	41	cancer	cancer	NOUN
bptjm-57	174	42	cells	cell	NOUN
bptjm-57	174	43	than	than	ADP
bptjm-57	174	44	mono	mono	NOUN
bptjm-57	174	45	-	-	PUNCT
bptjm-57	174	46	eats	eat	NOUN
bptjm-57	174	47	armed	arm	VERB
bptjm-57	174	48	with	with	ADP
bptjm-57	174	49	only	only	ADV
bptjm-57	174	50	one	one	NUM
bptjm-57	174	51	type	type	NOUN
bptjm-57	174	52	of	of	ADP
bptjm-57	174	53	bsab	bsab	NOUN
bptjm-57	174	54	.	.	PUNCT
bptjm-57	175	1	this	this	DET
bptjm-57	175	2	stronger	strong	ADJ
bptjm-57	175	3	cytotoxicity	cytotoxicity	NOUN
bptjm-57	175	4	resulted	result	VERB
bptjm-57	175	5	in	in	ADP
bptjm-57	175	6	a	a	DET
bptjm-57	175	7	more	more	ADV
bptjm-57	175	8	potent	potent	ADJ
bptjm-57	175	9	anti	anti	ADJ
bptjm-57	175	10	-	-	ADJ
bptjm-57	175	11	tumor	tumor	ADJ
bptjm-57	175	12	response	response	NOUN
bptjm-57	175	13	and	and	CCONJ
bptjm-57	175	14	dualand	dualand	NOUN
bptjm-57	175	15	multi	multi	ADJ
bptjm-57	175	16	-	-	ADJ
bptjm-57	175	17	eats	eat	NOUN
bptjm-57	175	18	exceeded	exceed	VERB
bptjm-57	175	19	the	the	DET
bptjm-57	175	20	e	e	PROPN
bptjm-57	175	21	�	�	PROPN
bptjm-57	175	22	cacy	cacy	NOUN
bptjm-57	175	23	of	of	ADP
bptjm-57	175	24	mono	mono	NOUN
bptjm-57	175	25	-	-	PUNCT
bptjm-57	175	26	eats	eat	NOUN
bptjm-57	175	27	,	,	PUNCT
bptjm-57	175	28	signi	signi	PROPN
bptjm-57	175	29	�	�	PROPN
bptjm-57	175	30	cantly	cantly	ADV
bptjm-57	175	31	improving	improve	VERB
bptjm-57	175	32	tumor	tumor	NOUN
bptjm-57	175	33	-	-	PUNCT
bptjm-57	175	34	free	free	ADJ
bptjm-57	175	35	survival	survival	NOUN
bptjm-57	175	36	.	.	PUNCT
bptjm-57	176	1	they	they	PRON
bptjm-57	176	2	,	,	PUNCT
bptjm-57	176	3	along	along	ADP
bptjm-57	176	4	with	with	ADP
bptjm-57	176	5	alternate	alternate	ADJ
bptjm-57	176	6	-	-	PUNCT
bptjm-57	176	7	eats	eat	NOUN
bptjm-57	176	8	,	,	PUNCT
bptjm-57	176	9	were	be	AUX
bptjm-57	176	10	also	also	ADV
bptjm-57	176	11	successful	successful	ADJ
bptjm-57	176	12	in	in	ADP
bptjm-57	176	13	inducing	induce	VERB
bptjm-57	176	14	tumor	tumor	NOUN
bptjm-57	176	15	regression	regression	NOUN
bptjm-57	176	16	,	,	PUNCT
bptjm-57	176	17	giving	give	VERB
bptjm-57	176	18	rise	rise	NOUN
bptjm-57	176	19	to	to	ADP
bptjm-57	176	20	long	long	ADJ
bptjm-57	176	21	-	-	PUNCT
bptjm-57	176	22	term	term	NOUN
bptjm-57	176	23	survival	survival	NOUN
bptjm-57	176	24	.	.	PUNCT
bptjm-57	177	1	furthermore	furthermore	ADV
bptjm-57	177	2	,	,	PUNCT
bptjm-57	177	3	dualand	dualand	PROPN
bptjm-57	177	4	multi	multi	ADJ
bptjm-57	177	5	-	-	ADJ
bptjm-57	177	6	eats	eat	NOUN
bptjm-57	177	7	exerted	exert	VERB
bptjm-57	177	8	a	a	DET
bptjm-57	177	9	synergistic	synergistic	ADJ
bptjm-57	177	10	anti	anti	ADJ
bptjm-57	177	11	-	-	ADJ
bptjm-57	177	12	tumor	tumor	ADJ
bptjm-57	177	13	e	e	NOUN
bptjm-57	177	14	�	�	NOUN
bptjm-57	177	15	ect	ect	VERB
bptjm-57	177	16	when	when	SCONJ
bptjm-57	177	17	they	they	PRON
bptjm-57	177	18	encountered	encounter	VERB
bptjm-57	177	19	multiple	multiple	ADJ
bptjm-57	177	20	antigens	antigen	NOUN
bptjm-57	177	21	simultaneously	simultaneously	ADV
bptjm-57	177	22	,	,	PUNCT
bptjm-57	177	23	which	which	PRON
bptjm-57	177	24	played	play	VERB
bptjm-57	177	25	a	a	DET
bptjm-57	177	26	signi	signi	ADJ
bptjm-57	177	27	�	�	NOUN
bptjm-57	177	28	cant	cant	NOUN
bptjm-57	177	29	role	role	NOUN
bptjm-57	177	30	in	in	ADP
bptjm-57	177	31	preventing	prevent	VERB
bptjm-57	177	32	antigen	antigen	NOUN
bptjm-57	177	33	loss.67	loss.67	NOUN
bptjm-57	177	34	however	however	ADV
bptjm-57	177	35	,	,	PUNCT
bptjm-57	177	36	experiments	experiment	NOUN
bptjm-57	177	37	have	have	AUX
bptjm-57	177	38	only	only	ADV
bptjm-57	177	39	been	be	AUX
bptjm-57	177	40	done	do	VERB
bptjm-57	177	41	in	in	ADP
bptjm-57	177	42	mouse	mouse	NOUN
bptjm-57	177	43	models	model	NOUN
bptjm-57	177	44	.	.	PUNCT
bptjm-57	178	1	even	even	ADV
bptjm-57	178	2	though	though	SCONJ
bptjm-57	178	3	no	no	DET
bptjm-57	178	4	additional	additional	ADJ
bptjm-57	178	5	toxicities	toxicity	NOUN
bptjm-57	178	6	that	that	PRON
bptjm-57	178	7	could	could	AUX
bptjm-57	178	8	cause	cause	VERB
bptjm-57	178	9	serious	serious	ADJ
bptjm-57	178	10	or	or	CCONJ
bptjm-57	178	11	fatal	fatal	ADJ
bptjm-57	178	12	e	e	NOUN
bptjm-57	178	13	�	�	NOUN
bptjm-57	178	14	ects	ect	VERB
bptjm-57	178	15	upon	upon	SCONJ
bptjm-57	178	16	infusion	infusion	NOUN
bptjm-57	178	17	of	of	ADP
bptjm-57	178	18	car	car	NOUN
bptjm-57	178	19	-	-	PUNCT
bptjm-57	178	20	t	t	NOUN
bptjm-57	178	21	cells	cell	NOUN
bptjm-57	178	22	or	or	CCONJ
bptjm-57	178	23	bsabs	bsab	NOUN
bptjm-57	178	24	were	be	AUX
bptjm-57	178	25	observed	observe	VERB
bptjm-57	178	26	,	,	PUNCT
bptjm-57	178	27	the	the	DET
bptjm-57	178	28	same	same	ADJ
bptjm-57	178	29	results	result	NOUN
bptjm-57	178	30	might	might	AUX
bptjm-57	178	31	not	not	PART
bptjm-57	178	32	be	be	AUX
bptjm-57	178	33	reproduced	reproduce	VERB
bptjm-57	178	34	in	in	ADP
bptjm-57	178	35	humans	human	NOUN
bptjm-57	178	36	.	.	PUNCT
bptjm-57	179	1	the	the	DET
bptjm-57	179	2	bsabs	bsab	NOUN
bptjm-57	179	3	also	also	ADV
bptjm-57	179	4	hold	hold	VERB
bptjm-57	179	5	speci	speci	ADJ
bptjm-57	179	6	�	�	PROPN
bptjm-57	179	7	city	city	NOUN
bptjm-57	179	8	for	for	ADP
bptjm-57	179	9	human	human	ADJ
bptjm-57	179	10	antigens	antigen	NOUN
bptjm-57	179	11	,	,	PUNCT
bptjm-57	179	12	not	not	PART
bptjm-57	179	13	mouse	mouse	NOUN
bptjm-57	179	14	antigens	antigen	NOUN
bptjm-57	179	15	,	,	PUNCT
bptjm-57	179	16	so	so	ADV
bptjm-57	179	17	using	use	VERB
bptjm-57	179	18	a	a	DET
bptjm-57	179	19	mouse	mouse	NOUN
bptjm-57	179	20	model	model	NOUN
bptjm-57	179	21	fails	fail	VERB
bptjm-57	179	22	to	to	PART
bptjm-57	179	23	mimic	mimic	VERB
bptjm-57	179	24	human	human	ADJ
bptjm-57	179	25	diseases	disease	NOUN
bptjm-57	179	26	and	and	CCONJ
bptjm-57	179	27	their	their	PRON
bptjm-57	179	28	therapeutics	therapeutic	NOUN
bptjm-57	179	29	perfectly	perfectly	ADV
bptjm-57	179	30	.	.	PUNCT
bptjm-57	180	1	although	although	SCONJ
bptjm-57	180	2	the	the	DET
bptjm-57	180	3	t	t	NOUN
bptjm-57	180	4	cells	cell	NOUN
bptjm-57	180	5	,	,	PUNCT
bptjm-57	180	6	tumors	tumor	NOUN
bptjm-57	180	7	,	,	PUNCT
bptjm-57	180	8	and	and	CCONJ
bptjm-57	180	9	bsabs	bsab	NOUN
bptjm-57	180	10	were	be	AUX
bptjm-57	180	11	of	of	ADP
bptjm-57	180	12	human	human	ADJ
bptjm-57	180	13	origin	origin	NOUN
bptjm-57	180	14	,	,	PUNCT
bptjm-57	180	15	the	the	DET
bptjm-57	180	16	tumor	tumor	NOUN
bptjm-57	180	17	microenvironment	microenvironment	NOUN
bptjm-57	180	18	contained	contain	VERB
bptjm-57	180	19	cells	cell	NOUN
bptjm-57	180	20	of	of	ADP
bptjm-57	180	21	mouse	mouse	NOUN
bptjm-57	180	22	origin	origin	NOUN
bptjm-57	180	23	,	,	PUNCT
bptjm-57	180	24	which	which	PRON
bptjm-57	180	25	included	include	VERB
bptjm-57	180	26	tumor	tumor	NOUN
bptjm-57	180	27	-	-	PUNCT
bptjm-57	180	28	in	in	ADP
bptjm-57	180	29	�	�	NOUN
bptjm-57	180	30	ltrating	ltrate	VERB
bptjm-57	180	31	myeloid	myeloid	ADJ
bptjm-57	180	32	cells	cell	NOUN
bptjm-57	180	33	,	,	PUNCT
bptjm-57	180	34	�	�	NOUN
bptjm-57	180	35	broblasts	broblast	NOUN
bptjm-57	180	36	,	,	PUNCT
bptjm-57	180	37	vasculature	vasculature	NOUN
bptjm-57	180	38	,	,	PUNCT
bptjm-57	180	39	and	and	CCONJ
bptjm-57	180	40	lymphatics	lymphatic	NOUN
bptjm-57	180	41	.	.	PUNCT
bptjm-57	181	1	these	these	PRON
bptjm-57	181	2	could	could	AUX
bptjm-57	181	3	interact	interact	VERB
bptjm-57	181	4	with	with	ADP
bptjm-57	181	5	one	one	NUM
bptjm-57	181	6	another	another	DET
bptjm-57	181	7	and	and	CCONJ
bptjm-57	181	8	a	a	DET
bptjm-57	181	9	�	�	NOUN
bptjm-57	181	10	ect	ect	NOUN
bptjm-57	181	11	tumorigenesis	tumorigenesis	NOUN
bptjm-57	181	12	and	and	CCONJ
bptjm-57	181	13	anti	anti	ADJ
bptjm-57	181	14	-	-	ADJ
bptjm-57	181	15	tumor	tumor	ADJ
bptjm-57	181	16	response	response	NOUN
bptjm-57	181	17	.	.	PUNCT
bptjm-57	182	1	despite	despite	SCONJ
bptjm-57	182	2	these	these	DET
bptjm-57	182	3	limitations	limitation	NOUN
bptjm-57	182	4	,	,	PUNCT
bptjm-57	182	5	dualand	dualand	NOUN
bptjm-57	182	6	multi	multi	ADJ
bptjm-57	182	7	-	-	ADJ
bptjm-57	182	8	eats	eat	NOUN
bptjm-57	182	9	have	have	VERB
bptjm-57	182	10	potential	potential	NOUN
bptjm-57	182	11	to	to	PART
bptjm-57	182	12	overcome	overcome	VERB
bptjm-57	182	13	tumor	tumor	NOUN
bptjm-57	182	14	heterogeneity	heterogeneity	NOUN
bptjm-57	182	15	and	and	CCONJ
bptjm-57	182	16	cancer	cancer	NOUN
bptjm-57	182	17	resistance.67	resistance.67	NOUN
bptjm-57	182	18	moreover	moreover	ADV
bptjm-57	182	19	,	,	PUNCT
bptjm-57	182	20	they	they	PRON
bptjm-57	182	21	could	could	AUX
bptjm-57	182	22	potentially	potentially	ADV
bptjm-57	182	23	be	be	AUX
bptjm-57	182	24	berkeley	berkeley	PROPN
bptjm-57	182	25	pharma	pharma	PROPN
bptjm-57	182	26	tech	tech	NOUN
bptjm-57	182	27	journal	journal	NOUN
bptjm-57	182	28	of	of	ADP
bptjm-57	182	29	medicine	medicine	NOUN
bptjm-57	183	1	|	|	ADV
bptjm-57	183	2	101	101	NUM
bptjm-57	183	3	used	use	VERB
bptjm-57	183	4	in	in	ADP
bptjm-57	183	5	more	more	ADV
bptjm-57	183	6	targeted	targeted	ADJ
bptjm-57	183	7	and	and	CCONJ
bptjm-57	183	8	personalized	personalized	ADJ
bptjm-57	183	9	treatments	treatment	NOUN
bptjm-57	183	10	by	by	ADP
bptjm-57	183	11	arming	arm	VERB
bptjm-57	183	12	the	the	DET
bptjm-57	183	13	t	t	NOUN
bptjm-57	183	14	cells	cell	NOUN
bptjm-57	183	15	with	with	ADP
bptjm-57	183	16	bsabs	bsab	NOUN
bptjm-57	183	17	that	that	PRON
bptjm-57	183	18	target	target	VERB
bptjm-57	183	19	speci	speci	PROPN
bptjm-57	183	20	�	�	PROPN
bptjm-57	183	21	c	c	PROPN
bptjm-57	183	22	taas	taas	NOUN
bptjm-57	183	23	found	find	VERB
bptjm-57	183	24	in	in	ADP
bptjm-57	183	25	a	a	DET
bptjm-57	183	26	patient	patient	NOUN
bptjm-57	183	27	’s	’s	PART
bptjm-57	183	28	tumor	tumor	NOUN
bptjm-57	183	29	.	.	PUNCT
bptjm-57	184	1	3.4	3.4	NUM
bptjm-57	184	2	nanornps	nanornps	NOUN
bptjm-57	184	3	with	with	ADP
bptjm-57	184	4	a	a	DET
bptjm-57	184	5	combination	combination	NOUN
bptjm-57	184	6	of	of	ADP
bptjm-57	184	7	single	single	ADJ
bptjm-57	184	8	guide	guide	NOUN
bptjm-57	184	9	rnas	rna	NOUN
bptjm-57	184	10	(	(	PUNCT
bptjm-57	184	11	sgrnas	sgrnas	PROPN
bptjm-57	184	12	)	)	PUNCT
bptjm-57	184	13	in	in	ADP
bptjm-57	184	14	the	the	DET
bptjm-57	184	15	early	early	ADJ
bptjm-57	184	16	stages	stage	NOUN
bptjm-57	184	17	of	of	ADP
bptjm-57	184	18	integrating	integrate	VERB
bptjm-57	184	19	nanotechnology	nanotechnology	NOUN
bptjm-57	184	20	into	into	ADP
bptjm-57	184	21	cancer	cancer	NOUN
bptjm-57	184	22	therapy	therapy	NOUN
bptjm-57	184	23	,	,	PUNCT
bptjm-57	184	24	profound	profound	ADJ
bptjm-57	184	25	strides	stride	NOUN
bptjm-57	184	26	were	be	AUX
bptjm-57	184	27	made	make	VERB
bptjm-57	184	28	in	in	ADP
bptjm-57	184	29	improving	improve	VERB
bptjm-57	184	30	existing	exist	VERB
bptjm-57	184	31	therapies	therapy	NOUN
bptjm-57	184	32	.	.	PUNCT
bptjm-57	185	1	one	one	NUM
bptjm-57	185	2	such	such	ADJ
bptjm-57	185	3	advancement	advancement	NOUN
bptjm-57	185	4	has	have	AUX
bptjm-57	185	5	been	be	AUX
bptjm-57	185	6	the	the	DET
bptjm-57	185	7	development	development	NOUN
bptjm-57	185	8	of	of	ADP
bptjm-57	185	9	nanotechnology	nanotechnology	NOUN
bptjm-57	185	10	-	-	PUNCT
bptjm-57	185	11	mediated	mediate	VERB
bptjm-57	185	12	drug	drug	NOUN
bptjm-57	185	13	delivery	delivery	NOUN
bptjm-57	185	14	systems	system	NOUN
bptjm-57	185	15	to	to	PART
bptjm-57	185	16	enhance	enhance	VERB
bptjm-57	185	17	their	their	PRON
bptjm-57	185	18	delivery	delivery	NOUN
bptjm-57	185	19	to	to	ADP
bptjm-57	185	20	tumor	tumor	NOUN
bptjm-57	185	21	sites	site	NOUN
bptjm-57	185	22	and	and	CCONJ
bptjm-57	185	23	reduce	reduce	VERB
bptjm-57	185	24	systemic	systemic	ADJ
bptjm-57	185	25	toxicity.68	toxicity.68	PROPN
bptjm-57	185	26	meanwhile	meanwhile	ADV
bptjm-57	185	27	,	,	PUNCT
bptjm-57	185	28	nano	nano	NOUN
bptjm-57	185	29	-	-	PUNCT
bptjm-57	185	30	cas9	cas9	NOUN
bptjm-57	185	31	ribonucleoprotein	ribonucleoprotein	NOUN
bptjm-57	185	32	(	(	PUNCT
bptjm-57	185	33	nanornp	nanornp	PROPN
bptjm-57	185	34	)	)	PUNCT
bptjm-57	185	35	with	with	ADP
bptjm-57	185	36	a	a	DET
bptjm-57	185	37	combination	combination	NOUN
bptjm-57	185	38	of	of	ADP
bptjm-57	185	39	sgrnas	sgrnas	NOUN
bptjm-57	185	40	harnesses	harness	NOUN
bptjm-57	185	41	the	the	DET
bptjm-57	185	42	full	full	ADJ
bptjm-57	185	43	potency	potency	NOUN
bptjm-57	185	44	of	of	ADP
bptjm-57	185	45	nanotechnology	nanotechnology	NOUN
bptjm-57	185	46	and	and	CCONJ
bptjm-57	185	47	gene	gene	NOUN
bptjm-57	185	48	editing	edit	VERB
bptjm-57	185	49	for	for	ADP
bptjm-57	185	50	precision	precision	NOUN
bptjm-57	185	51	treatment	treatment	NOUN
bptjm-57	185	52	.	.	PUNCT
bptjm-57	186	1	in	in	ADP
bptjm-57	186	2	a	a	DET
bptjm-57	186	3	study	study	NOUN
bptjm-57	186	4	by	by	ADP
bptjm-57	186	5	liu	liu	PROPN
bptjm-57	186	6	et	et	PROPN
bptjm-57	186	7	al	al	PROPN
bptjm-57	186	8	.	.	PROPN
bptjm-57	186	9	,	,	PUNCT
bptjm-57	186	10	a	a	DET
bptjm-57	186	11	nanornp	nanornp	PROPN
bptjm-57	186	12	system	system	NOUN
bptjm-57	186	13	that	that	PRON
bptjm-57	186	14	could	could	AUX
bptjm-57	186	15	carry	carry	VERB
bptjm-57	186	16	any	any	DET
bptjm-57	186	17	combination	combination	NOUN
bptjm-57	186	18	of	of	ADP
bptjm-57	186	19	sgrnas	sgrnas	NOUN
bptjm-57	186	20	was	be	AUX
bptjm-57	186	21	demonstrated	demonstrate	VERB
bptjm-57	186	22	to	to	PART
bptjm-57	186	23	achieve	achieve	VERB
bptjm-57	186	24	targeted	target	VERB
bptjm-57	186	25	gene	gene	NOUN
bptjm-57	186	26	disruption	disruption	NOUN
bptjm-57	186	27	and	and	CCONJ
bptjm-57	186	28	e	e	NOUN
bptjm-57	186	29	�	�	NOUN
bptjm-57	186	30	ective	ective	ADJ
bptjm-57	186	31	suppression	suppression	NOUN
bptjm-57	186	32	of	of	ADP
bptjm-57	186	33	heterogeneous	heterogeneous	ADJ
bptjm-57	186	34	tumors	tumor	NOUN
bptjm-57	186	35	.	.	PUNCT
bptjm-57	187	1	nanornp	nanornp	PROPN
bptjm-57	187	2	has	have	VERB
bptjm-57	187	3	a	a	DET
bptjm-57	187	4	core	core	ADJ
bptjm-57	187	5	-	-	PUNCT
bptjm-57	187	6	shell	shell	NOUN
bptjm-57	187	7	structure	structure	NOUN
bptjm-57	187	8	linked	link	VERB
bptjm-57	187	9	by	by	ADP
bptjm-57	187	10	ca	ca	NOUN
bptjm-57	187	11	that	that	PRON
bptjm-57	187	12	degrades	degrade	VERB
bptjm-57	187	13	under	under	ADP
bptjm-57	187	14	acidic	acidic	ADJ
bptjm-57	187	15	conditions	condition	NOUN
bptjm-57	187	16	.	.	PUNCT
bptjm-57	188	1	this	this	DET
bptjm-57	188	2	way	way	NOUN
bptjm-57	188	3	,	,	PUNCT
bptjm-57	188	4	it	it	PRON
bptjm-57	188	5	maintains	maintain	VERB
bptjm-57	188	6	a	a	DET
bptjm-57	188	7	stable	stable	ADJ
bptjm-57	188	8	structure	structure	NOUN
bptjm-57	188	9	in	in	ADP
bptjm-57	188	10	blood	blood	NOUN
bptjm-57	188	11	circulation	circulation	NOUN
bptjm-57	188	12	and	and	CCONJ
bptjm-57	188	13	normal	normal	ADJ
bptjm-57	188	14	organs	organ	NOUN
bptjm-57	188	15	but	but	CCONJ
bptjm-57	188	16	detaches	detach	VERB
bptjm-57	188	17	its	its	PRON
bptjm-57	188	18	shell	shell	NOUN
bptjm-57	188	19	when	when	SCONJ
bptjm-57	188	20	in	in	ADP
bptjm-57	188	21	the	the	DET
bptjm-57	188	22	acidic	acidic	ADJ
bptjm-57	188	23	tumor	tumor	NOUN
bptjm-57	188	24	microenvironment	microenvironment	NOUN
bptjm-57	188	25	.	.	PUNCT
bptjm-57	189	1	this	this	DET
bptjm-57	189	2	action	action	NOUN
bptjm-57	189	3	facilitates	facilitate	VERB
bptjm-57	189	4	tumor	tumor	NOUN
bptjm-57	189	5	accumulation	accumulation	NOUN
bptjm-57	189	6	,	,	PUNCT
bptjm-57	189	7	cell	cell	NOUN
bptjm-57	189	8	internalization	internalization	NOUN
bptjm-57	189	9	,	,	PUNCT
bptjm-57	189	10	and	and	CCONJ
bptjm-57	189	11	eventual	eventual	ADJ
bptjm-57	189	12	gene	gene	NOUN
bptjm-57	189	13	editing	editing	NOUN
bptjm-57	189	14	by	by	ADP
bptjm-57	189	15	the	the	DET
bptjm-57	189	16	cas9	cas9	PROPN
bptjm-57	189	17	/	/	SYM
bptjm-57	189	18	sgrna	sgrna	PROPN
bptjm-57	189	19	complex	complex	NOUN
bptjm-57	189	20	in	in	ADP
bptjm-57	189	21	its	its	PRON
bptjm-57	189	22	core	core	NOUN
bptjm-57	189	23	.	.	PUNCT
bptjm-57	190	1	with	with	ADP
bptjm-57	190	2	cas9	cas9	PROPN
bptjm-57	190	3	,	,	PUNCT
bptjm-57	190	4	nanornps	nanornps	PROPN
bptjm-57	190	5	can	can	AUX
bptjm-57	190	6	disrupt	disrupt	VERB
bptjm-57	190	7	the	the	DET
bptjm-57	190	8	targeted	target	VERB
bptjm-57	190	9	gene	gene	NOUN
bptjm-57	190	10	sequence	sequence	NOUN
bptjm-57	190	11	under	under	ADP
bptjm-57	190	12	acidic	acidic	ADJ
bptjm-57	190	13	conditions	condition	NOUN
bptjm-57	190	14	,	,	PUNCT
bptjm-57	190	15	signi	signi	PROPN
bptjm-57	190	16	�	�	PROPN
bptjm-57	190	17	cantly	cantly	ADV
bptjm-57	190	18	downregulating	downregulate	VERB
bptjm-57	190	19	the	the	DET
bptjm-57	190	20	expression	expression	NOUN
bptjm-57	190	21	of	of	ADP
bptjm-57	190	22	the	the	DET
bptjm-57	190	23	target	target	NOUN
bptjm-57	190	24	genes	gene	NOUN
bptjm-57	190	25	.	.	PUNCT
bptjm-57	191	1	when	when	SCONJ
bptjm-57	191	2	nanornps	nanornps	PROPN
bptjm-57	191	3	carry	carry	VERB
bptjm-57	191	4	a	a	DET
bptjm-57	191	5	combination	combination	NOUN
bptjm-57	191	6	of	of	ADP
bptjm-57	191	7	sgrnas	sgrna	NOUN
bptjm-57	191	8	,	,	PUNCT
bptjm-57	191	9	they	they	PRON
bptjm-57	191	10	simultaneously	simultaneously	ADV
bptjm-57	191	11	disrupt	disrupt	VERB
bptjm-57	191	12	the	the	DET
bptjm-57	191	13	expression	expression	NOUN
bptjm-57	191	14	of	of	ADP
bptjm-57	191	15	multiple	multiple	ADJ
bptjm-57	191	16	target	target	NOUN
bptjm-57	191	17	genes	gene	NOUN
bptjm-57	191	18	,	,	PUNCT
bptjm-57	191	19	and	and	CCONJ
bptjm-57	191	20	this	this	PRON
bptjm-57	191	21	could	could	AUX
bptjm-57	191	22	potentially	potentially	ADV
bptjm-57	191	23	overcome	overcome	VERB
bptjm-57	191	24	the	the	DET
bptjm-57	191	25	genetic	genetic	ADJ
bptjm-57	191	26	heterogeneity	heterogeneity	NOUN
bptjm-57	191	27	that	that	PRON
bptjm-57	191	28	causes	cause	VERB
bptjm-57	191	29	treatment	treatment	NOUN
bptjm-57	191	30	resistance	resistance	NOUN
bptjm-57	191	31	in	in	ADP
bptjm-57	191	32	cancer.69	cancer.69	NOUN
bptjm-57	191	33	in	in	ADP
bptjm-57	191	34	a	a	DET
bptjm-57	191	35	heterogeneous	heterogeneous	ADJ
bptjm-57	191	36	tumor	tumor	NOUN
bptjm-57	191	37	model	model	NOUN
bptjm-57	191	38	at	at	ADP
bptjm-57	191	39	ph	ph	PROPN
bptjm-57	191	40	6.5	6.5	NUM
bptjm-57	191	41	,	,	PUNCT
bptjm-57	191	42	liu	liu	PROPN
bptjm-57	191	43	et	et	PROPN
bptjm-57	191	44	al	al	PROPN
bptjm-57	191	45	.	.	PROPN
bptjm-57	191	46	expressed	express	VERB
bptjm-57	191	47	the	the	DET
bptjm-57	191	48	target	target	NOUN
bptjm-57	191	49	genes	gene	NOUN
bptjm-57	191	50	stat3	stat3	NOUN
bptjm-57	191	51	,	,	PUNCT
bptjm-57	191	52	which	which	PRON
bptjm-57	191	53	increases	increase	VERB
bptjm-57	191	54	tumor	tumor	NOUN
bptjm-57	191	55	cell	cell	NOUN
bptjm-57	191	56	proliferation	proliferation	NOUN
bptjm-57	191	57	,	,	PUNCT
bptjm-57	191	58	survival	survival	NOUN
bptjm-57	191	59	,	,	PUNCT
bptjm-57	191	60	and	and	CCONJ
bptjm-57	191	61	invasion	invasion	NOUN
bptjm-57	191	62	while	while	SCONJ
bptjm-57	191	63	suppressing	suppress	VERB
bptjm-57	191	64	immunity	immunity	NOUN
bptjm-57	191	65	towards	towards	ADP
bptjm-57	191	66	tumors	tumor	NOUN
bptjm-57	191	67	,	,	PUNCT
bptjm-57	191	68	and	and	CCONJ
bptjm-57	191	69	runx1	runx1	PROPN
bptjm-57	191	70	,	,	PUNCT
bptjm-57	191	71	whose	whose	DET
bptjm-57	191	72	increased	increase	VERB
bptjm-57	191	73	levels	level	NOUN
bptjm-57	191	74	correlate	correlate	VERB
bptjm-57	191	75	with	with	ADP
bptjm-57	191	76	cancer	cancer	NOUN
bptjm-57	191	77	cell	cell	NOUN
bptjm-57	191	78	proliferation	proliferation	NOUN
bptjm-57	191	79	,	,	PUNCT
bptjm-57	191	80	tumoral	tumoral	ADJ
bptjm-57	191	81	angiogenesis	angiogenesis	NOUN
bptjm-57	191	82	,	,	PUNCT
bptjm-57	191	83	and	and	CCONJ
bptjm-57	191	84	metastasis	metastasis	NOUN
bptjm-57	191	85	.	.	PUNCT
bptjm-57	192	1	the	the	DET
bptjm-57	192	2	nanornp	nanornp	PROPN
bptjm-57	192	3	carrying	carry	VERB
bptjm-57	192	4	a	a	DET
bptjm-57	192	5	combination	combination	NOUN
bptjm-57	192	6	of	of	ADP
bptjm-57	192	7	sgrnas	sgrna	NOUN
bptjm-57	192	8	,	,	PUNCT
bptjm-57	192	9	nanornp	nanornp	NOUN
bptjm-57	192	10	-	-	PUNCT
bptjm-57	192	11	stat3+runx1	stat3+runx1	PROPN
bptjm-57	192	12	,	,	PUNCT
bptjm-57	192	13	disrupted	disrupt	VERB
bptjm-57	192	14	the	the	DET
bptjm-57	192	15	expression	expression	NOUN
bptjm-57	192	16	of	of	ADP
bptjm-57	192	17	both	both	DET
bptjm-57	192	18	genes	gene	NOUN
bptjm-57	192	19	,	,	PUNCT
bptjm-57	192	20	inhibiting	inhibit	VERB
bptjm-57	192	21	the	the	DET
bptjm-57	192	22	proliferation	proliferation	NOUN
bptjm-57	192	23	of	of	ADP
bptjm-57	192	24	the	the	DET
bptjm-57	192	25	tumor	tumor	NOUN
bptjm-57	192	26	cells	cell	NOUN
bptjm-57	192	27	.	.	PUNCT
bptjm-57	193	1	it	it	PRON
bptjm-57	193	2	also	also	ADV
bptjm-57	193	3	increasingly	increasingly	ADV
bptjm-57	193	4	induced	induce	VERB
bptjm-57	193	5	cell	cell	NOUN
bptjm-57	193	6	apoptosis	apoptosis	NOUN
bptjm-57	193	7	in	in	ADP
bptjm-57	193	8	the	the	DET
bptjm-57	193	9	tumor	tumor	NOUN
bptjm-57	193	10	.	.	PUNCT
bptjm-57	194	1	in	in	ADP
bptjm-57	194	2	contrast	contrast	NOUN
bptjm-57	194	3	,	,	PUNCT
bptjm-57	194	4	nanornps	nanornps	PROPN
bptjm-57	194	5	carrying	carry	VERB
bptjm-57	194	6	a	a	DET
bptjm-57	194	7	berkeley	berkeley	PROPN
bptjm-57	194	8	pharma	pharma	PROPN
bptjm-57	194	9	tech	tech	NOUN
bptjm-57	194	10	journal	journal	NOUN
bptjm-57	194	11	of	of	ADP
bptjm-57	194	12	medicine	medicine	NOUN
bptjm-57	194	13	|	|	ADV
bptjm-57	194	14	102	102	NUM
bptjm-57	194	15	single	single	ADJ
bptjm-57	194	16	type	type	NOUN
bptjm-57	194	17	of	of	ADP
bptjm-57	194	18	sgrna	sgrna	NOUN
bptjm-57	194	19	led	lead	VERB
bptjm-57	194	20	to	to	ADP
bptjm-57	194	21	the	the	DET
bptjm-57	194	22	reduced	reduced	ADJ
bptjm-57	194	23	expression	expression	NOUN
bptjm-57	194	24	of	of	ADP
bptjm-57	194	25	only	only	ADV
bptjm-57	194	26	one	one	NUM
bptjm-57	194	27	of	of	ADP
bptjm-57	194	28	the	the	DET
bptjm-57	194	29	genes	gene	NOUN
bptjm-57	194	30	,	,	PUNCT
bptjm-57	194	31	resulting	result	VERB
bptjm-57	194	32	in	in	ADP
bptjm-57	194	33	partial	partial	ADJ
bptjm-57	194	34	growth	growth	NOUN
bptjm-57	194	35	inhibition	inhibition	NOUN
bptjm-57	194	36	in	in	ADP
bptjm-57	194	37	the	the	DET
bptjm-57	194	38	heterogeneous	heterogeneous	ADJ
bptjm-57	194	39	tumor	tumor	NOUN
bptjm-57	194	40	.	.	PUNCT
bptjm-57	195	1	however	however	ADV
bptjm-57	195	2	,	,	PUNCT
bptjm-57	195	3	through	through	ADP
bptjm-57	195	4	an	an	DET
bptjm-57	195	5	analysis	analysis	NOUN
bptjm-57	195	6	of	of	ADP
bptjm-57	195	7	gene	gene	NOUN
bptjm-57	195	8	disruption	disruption	NOUN
bptjm-57	195	9	on	on	ADP
bptjm-57	195	10	stat3	stat3	NOUN
bptjm-57	195	11	and	and	CCONJ
bptjm-57	195	12	runx1	runx1	PROPN
bptjm-57	195	13	,	,	PUNCT
bptjm-57	195	14	it	it	PRON
bptjm-57	195	15	was	be	AUX
bptjm-57	195	16	discovered	discover	VERB
bptjm-57	195	17	that	that	SCONJ
bptjm-57	195	18	complete	complete	ADJ
bptjm-57	195	19	reduction	reduction	NOUN
bptjm-57	195	20	of	of	ADP
bptjm-57	195	21	the	the	DET
bptjm-57	195	22	target	target	NOUN
bptjm-57	195	23	genes	gene	NOUN
bptjm-57	195	24	could	could	AUX
bptjm-57	195	25	not	not	PART
bptjm-57	195	26	be	be	AUX
bptjm-57	195	27	achieved	achieve	VERB
bptjm-57	195	28	by	by	ADP
bptjm-57	195	29	the	the	DET
bptjm-57	195	30	nanornp	nanornp	PROPN
bptjm-57	195	31	,	,	PUNCT
bptjm-57	195	32	even	even	ADV
bptjm-57	195	33	if	if	SCONJ
bptjm-57	195	34	it	it	PRON
bptjm-57	195	35	carried	carry	VERB
bptjm-57	195	36	multiple	multiple	ADJ
bptjm-57	195	37	di	di	NOUN
bptjm-57	195	38	�	�	PROPN
bptjm-57	195	39	erent	erent	NOUN
bptjm-57	195	40	sgrnas	sgrna	NOUN
bptjm-57	195	41	.	.	PUNCT
bptjm-57	196	1	even	even	ADV
bptjm-57	196	2	so	so	ADV
bptjm-57	196	3	,	,	PUNCT
bptjm-57	196	4	nanornps	nanornps	PROPN
bptjm-57	196	5	carrying	carry	VERB
bptjm-57	196	6	a	a	DET
bptjm-57	196	7	combination	combination	NOUN
bptjm-57	196	8	of	of	ADP
bptjm-57	196	9	sgrnas	sgrnas	NOUN
bptjm-57	196	10	could	could	AUX
bptjm-57	196	11	simultaneously	simultaneously	ADV
bptjm-57	196	12	suppress	suppress	VERB
bptjm-57	196	13	the	the	DET
bptjm-57	196	14	proliferation	proliferation	NOUN
bptjm-57	196	15	of	of	ADP
bptjm-57	196	16	multiple	multiple	ADJ
bptjm-57	196	17	tumor	tumor	NOUN
bptjm-57	196	18	cell	cell	NOUN
bptjm-57	196	19	subpopulations	subpopulation	NOUN
bptjm-57	196	20	,	,	PUNCT
bptjm-57	196	21	showing	show	VERB
bptjm-57	196	22	their	their	PRON
bptjm-57	196	23	potential	potential	NOUN
bptjm-57	196	24	to	to	PART
bptjm-57	196	25	overcome	overcome	VERB
bptjm-57	196	26	tumor	tumor	NOUN
bptjm-57	196	27	heterogeneity.69	heterogeneity.69	NOUN
bptjm-57	196	28	similar	similar	ADJ
bptjm-57	196	29	to	to	AUX
bptjm-57	196	30	dualor	dualor	VERB
bptjm-57	196	31	multi	multi	NOUN
bptjm-57	196	32	-	-	ADJ
bptjm-57	196	33	eats	eat	NOUN
bptjm-57	196	34	,	,	PUNCT
bptjm-57	196	35	this	this	DET
bptjm-57	196	36	treatment	treatment	NOUN
bptjm-57	196	37	strategy	strategy	NOUN
bptjm-57	196	38	can	can	AUX
bptjm-57	196	39	be	be	AUX
bptjm-57	196	40	used	use	VERB
bptjm-57	196	41	in	in	ADP
bptjm-57	196	42	a	a	DET
bptjm-57	196	43	more	more	ADV
bptjm-57	196	44	personalized	personalized	ADJ
bptjm-57	196	45	approach	approach	NOUN
bptjm-57	196	46	,	,	PUNCT
bptjm-57	196	47	wherein	wherein	SCONJ
bptjm-57	196	48	the	the	DET
bptjm-57	196	49	nanornps	nanornps	NOUN
bptjm-57	196	50	could	could	AUX
bptjm-57	196	51	carry	carry	VERB
bptjm-57	196	52	the	the	DET
bptjm-57	196	53	sgrnas	sgrnas	NOUN
bptjm-57	196	54	required	require	VERB
bptjm-57	196	55	to	to	PART
bptjm-57	196	56	disrupt	disrupt	VERB
bptjm-57	196	57	the	the	DET
bptjm-57	196	58	speci	speci	PROPN
bptjm-57	196	59	�	�	PROPN
bptjm-57	196	60	c	c	PROPN
bptjm-57	196	61	target	target	NOUN
bptjm-57	196	62	genes	gene	NOUN
bptjm-57	196	63	expressed	express	VERB
bptjm-57	196	64	in	in	ADP
bptjm-57	196	65	a	a	DET
bptjm-57	196	66	patient	patient	NOUN
bptjm-57	196	67	’s	’s	PART
bptjm-57	196	68	tumor	tumor	NOUN
bptjm-57	196	69	.	.	PUNCT
bptjm-57	197	1	3.5	3.5	NUM
bptjm-57	197	2	circulating	circulate	VERB
bptjm-57	197	3	tumor	tumor	NOUN
bptjm-57	197	4	cells	cell	NOUN
bptjm-57	197	5	(	(	PUNCT
bptjm-57	197	6	ctcs	ctcs	NOUN
bptjm-57	197	7	)	)	PUNCT
bptjm-57	197	8	ctcs	ctcs	NOUN
bptjm-57	197	9	,	,	PUNCT
bptjm-57	197	10	rather	rather	ADV
bptjm-57	197	11	than	than	ADP
bptjm-57	197	12	a	a	DET
bptjm-57	197	13	treatment	treatment	NOUN
bptjm-57	197	14	,	,	PUNCT
bptjm-57	197	15	are	be	AUX
bptjm-57	197	16	better	well	ADV
bptjm-57	197	17	described	describe	VERB
bptjm-57	197	18	as	as	ADP
bptjm-57	197	19	a	a	DET
bptjm-57	197	20	research	research	NOUN
bptjm-57	197	21	methodology	methodology	NOUN
bptjm-57	197	22	.	.	PUNCT
bptjm-57	198	1	they	they	PRON
bptjm-57	198	2	are	be	AUX
bptjm-57	198	3	cells	cell	NOUN
bptjm-57	198	4	in	in	ADP
bptjm-57	198	5	the	the	DET
bptjm-57	198	6	blood	blood	NOUN
bptjm-57	198	7	that	that	PRON
bptjm-57	198	8	come	come	VERB
bptjm-57	198	9	from	from	ADP
bptjm-57	198	10	a	a	DET
bptjm-57	198	11	tumor	tumor	NOUN
bptjm-57	198	12	,	,	PUNCT
bptjm-57	198	13	and	and	CCONJ
bptjm-57	198	14	they	they	PRON
bptjm-57	198	15	have	have	VERB
bptjm-57	198	16	the	the	DET
bptjm-57	198	17	potential	potential	NOUN
bptjm-57	198	18	to	to	PART
bptjm-57	198	19	become	become	VERB
bptjm-57	198	20	the	the	DET
bptjm-57	198	21	primary	primary	ADJ
bptjm-57	198	22	way	way	NOUN
bptjm-57	198	23	to	to	PART
bptjm-57	198	24	test	test	VERB
bptjm-57	198	25	and	and	CCONJ
bptjm-57	198	26	develop	develop	VERB
bptjm-57	198	27	new	new	ADJ
bptjm-57	198	28	drugs	drug	NOUN
bptjm-57	198	29	,	,	PUNCT
bptjm-57	198	30	as	as	ADV
bptjm-57	198	31	well	well	ADV
bptjm-57	198	32	as	as	ADP
bptjm-57	198	33	to	to	PART
bptjm-57	198	34	test	test	VERB
bptjm-57	198	35	for	for	ADP
bptjm-57	198	36	the	the	DET
bptjm-57	198	37	progression	progression	NOUN
bptjm-57	198	38	of	of	ADP
bptjm-57	198	39	cancer	cancer	NOUN
bptjm-57	198	40	.	.	PUNCT
bptjm-57	199	1	more	more	ADJ
bptjm-57	199	2	traditional	traditional	ADJ
bptjm-57	199	3	methods	method	NOUN
bptjm-57	199	4	have	have	VERB
bptjm-57	199	5	various	various	ADJ
bptjm-57	199	6	problems	problem	NOUN
bptjm-57	199	7	.	.	PUNCT
bptjm-57	200	1	for	for	ADP
bptjm-57	200	2	instance	instance	NOUN
bptjm-57	200	3	,	,	PUNCT
bptjm-57	200	4	2d	2d	NUM
bptjm-57	200	5	cultures	culture	NOUN
bptjm-57	200	6	lack	lack	VERB
bptjm-57	200	7	the	the	DET
bptjm-57	200	8	complexity	complexity	NOUN
bptjm-57	200	9	of	of	ADP
bptjm-57	200	10	a	a	DET
bptjm-57	200	11	tumor	tumor	NOUN
bptjm-57	200	12	structurally	structurally	ADV
bptjm-57	200	13	on	on	ADP
bptjm-57	200	14	the	the	DET
bptjm-57	200	15	genetic	genetic	ADJ
bptjm-57	200	16	and	and	CCONJ
bptjm-57	200	17	physical	physical	ADJ
bptjm-57	200	18	level	level	NOUN
bptjm-57	200	19	but	but	CCONJ
bptjm-57	200	20	can	can	AUX
bptjm-57	200	21	be	be	AUX
bptjm-57	200	22	tested	test	VERB
bptjm-57	200	23	in	in	ADP
bptjm-57	200	24	high	high	ADJ
bptjm-57	200	25	volumes	volume	NOUN
bptjm-57	200	26	at	at	ADP
bptjm-57	200	27	high	high	ADJ
bptjm-57	200	28	speeds	speed	NOUN
bptjm-57	200	29	.	.	PUNCT
bptjm-57	201	1	patient	patient	NOUN
bptjm-57	201	2	-	-	PUNCT
bptjm-57	201	3	derived	derive	VERB
bptjm-57	201	4	xenografts	xenograft	NOUN
bptjm-57	201	5	�	�	PROPN
bptjm-57	201	6	x	x	PROPN
bptjm-57	201	7	the	the	DET
bptjm-57	201	8	structural	structural	ADJ
bptjm-57	201	9	problems	problem	NOUN
bptjm-57	201	10	of	of	ADP
bptjm-57	201	11	2d	2d	NUM
bptjm-57	201	12	cultures	culture	NOUN
bptjm-57	201	13	,	,	PUNCT
bptjm-57	201	14	but	but	CCONJ
bptjm-57	201	15	they	they	PRON
bptjm-57	201	16	are	be	AUX
bptjm-57	201	17	unable	unable	ADJ
bptjm-57	201	18	to	to	PART
bptjm-57	201	19	be	be	AUX
bptjm-57	201	20	used	use	VERB
bptjm-57	201	21	in	in	ADP
bptjm-57	201	22	high	high	ADJ
bptjm-57	201	23	-	-	PUNCT
bptjm-57	201	24	throughput	throughput	NOUN
bptjm-57	201	25	screenings	screening	NOUN
bptjm-57	201	26	,	,	PUNCT
bptjm-57	201	27	which	which	PRON
bptjm-57	201	28	signi	signi	VERB
bptjm-57	201	29	�	�	PROPN
bptjm-57	201	30	cantly	cantly	ADV
bptjm-57	201	31	reduces	reduce	VERB
bptjm-57	201	32	research	research	NOUN
bptjm-57	201	33	speed	speed	NOUN
bptjm-57	201	34	.	.	PUNCT
bptjm-57	202	1	ctcs	ctcs	PROPN
bptjm-57	202	2	maintain	maintain	VERB
bptjm-57	202	3	the	the	DET
bptjm-57	202	4	level	level	NOUN
bptjm-57	202	5	of	of	ADP
bptjm-57	202	6	heterogeneity	heterogeneity	NOUN
bptjm-57	202	7	and	and	CCONJ
bptjm-57	202	8	the	the	DET
bptjm-57	202	9	tumor	tumor	NOUN
bptjm-57	202	10	’s	’s	PART
bptjm-57	202	11	structure	structure	NOUN
bptjm-57	202	12	,	,	PUNCT
bptjm-57	202	13	which	which	PRON
bptjm-57	202	14	allows	allow	VERB
bptjm-57	202	15	for	for	ADP
bptjm-57	202	16	high	high	ADJ
bptjm-57	202	17	-	-	PUNCT
bptjm-57	202	18	throughput	throughput	NOUN
bptjm-57	202	19	screenings	screening	NOUN
bptjm-57	202	20	.	.	PUNCT
bptjm-57	203	1	these	these	DET
bptjm-57	203	2	advantages	advantage	NOUN
bptjm-57	203	3	allow	allow	VERB
bptjm-57	203	4	for	for	ADP
bptjm-57	203	5	new	new	ADJ
bptjm-57	203	6	and	and	CCONJ
bptjm-57	203	7	more	more	ADV
bptjm-57	203	8	personalized	personalized	ADJ
bptjm-57	203	9	treatments	treatment	NOUN
bptjm-57	203	10	as	as	SCONJ
bptjm-57	203	11	these	these	DET
bptjm-57	203	12	therapies	therapy	NOUN
bptjm-57	203	13	can	can	AUX
bptjm-57	203	14	be	be	AUX
bptjm-57	203	15	tested	test	VERB
bptjm-57	203	16	on	on	ADP
bptjm-57	203	17	an	an	DET
bptjm-57	203	18	accurate	accurate	ADJ
bptjm-57	203	19	model	model	NOUN
bptjm-57	203	20	that	that	PRON
bptjm-57	203	21	poses	pose	VERB
bptjm-57	203	22	zero	zero	NUM
bptjm-57	203	23	risk	risk	NOUN
bptjm-57	203	24	for	for	ADP
bptjm-57	203	25	the	the	DET
bptjm-57	203	26	patient.70	patient.70	NOUN
bptjm-57	203	27	the	the	DET
bptjm-57	203	28	greatest	great	ADJ
bptjm-57	203	29	challenge	challenge	NOUN
bptjm-57	203	30	to	to	ADP
bptjm-57	203	31	utilizing	utilize	VERB
bptjm-57	203	32	ctcs	ctcs	NOUN
bptjm-57	203	33	is	be	AUX
bptjm-57	203	34	accurately	accurately	ADV
bptjm-57	203	35	isolating	isolate	VERB
bptjm-57	203	36	them	they	PRON
bptjm-57	203	37	from	from	ADP
bptjm-57	203	38	other	other	ADJ
bptjm-57	203	39	cells	cell	NOUN
bptjm-57	203	40	in	in	ADP
bptjm-57	203	41	the	the	DET
bptjm-57	203	42	blood	blood	NOUN
bptjm-57	203	43	since	since	SCONJ
bptjm-57	203	44	ctcs	ctcs	NOUN
bptjm-57	203	45	are	be	AUX
bptjm-57	203	46	very	very	ADV
bptjm-57	203	47	rare	rare	ADJ
bptjm-57	203	48	in	in	ADP
bptjm-57	203	49	the	the	DET
bptjm-57	203	50	blood	blood	NOUN
bptjm-57	203	51	and	and	CCONJ
bptjm-57	203	52	little	little	ADJ
bptjm-57	203	53	is	be	AUX
bptjm-57	203	54	known	know	VERB
bptjm-57	203	55	about	about	ADP
bptjm-57	203	56	their	their	PRON
bptjm-57	203	57	genetic	genetic	ADJ
bptjm-57	203	58	structure.71,72	structure.71,72	NOUN
bptjm-57	203	59	ctcs	ctcs	NOUN
bptjm-57	203	60	can	can	AUX
bptjm-57	203	61	be	be	AUX
bptjm-57	203	62	isolated	isolate	VERB
bptjm-57	203	63	based	base	VERB
bptjm-57	203	64	on	on	ADP
bptjm-57	203	65	di	di	PROPN
bptjm-57	203	66	�	�	PROPN
bptjm-57	203	67	erences	erence	NOUN
bptjm-57	203	68	in	in	ADP
bptjm-57	203	69	their	their	PRON
bptjm-57	203	70	physical	physical	ADJ
bptjm-57	203	71	properties	property	NOUN
bptjm-57	203	72	,	,	PUNCT
bptjm-57	203	73	such	such	ADJ
bptjm-57	203	74	as	as	ADP
bptjm-57	203	75	density	density	NOUN
bptjm-57	203	76	,	,	PUNCT
bptjm-57	203	77	size	size	NOUN
bptjm-57	203	78	,	,	PUNCT
bptjm-57	203	79	deformability	deformability	NOUN
bptjm-57	203	80	,	,	PUNCT
bptjm-57	203	81	and	and	CCONJ
bptjm-57	203	82	electrical	electrical	ADJ
bptjm-57	203	83	properties	property	NOUN
bptjm-57	203	84	.	.	PUNCT
bptjm-57	204	1	however	however	ADV
bptjm-57	204	2	,	,	PUNCT
bptjm-57	204	3	these	these	DET
bptjm-57	204	4	methods	method	NOUN
bptjm-57	204	5	are	be	AUX
bptjm-57	204	6	very	very	ADV
bptjm-57	204	7	ine	ine	PROPN
bptjm-57	204	8	�	�	PROPN
bptjm-57	204	9	cient	cient	PROPN
bptjm-57	204	10	as	as	SCONJ
bptjm-57	204	11	they	they	PRON
bptjm-57	204	12	lack	lack	VERB
bptjm-57	204	13	purity	purity	NOUN
bptjm-57	204	14	and	and	CCONJ
bptjm-57	204	15	speci	speci	PROPN
bptjm-57	204	16	�	�	PROPN
bptjm-57	204	17	city	city	PROPN
bptjm-57	204	18	.	.	PUNCT
bptjm-57	205	1	for	for	ADP
bptjm-57	205	2	this	this	DET
bptjm-57	205	3	reason	reason	NOUN
bptjm-57	205	4	,	,	PUNCT
bptjm-57	205	5	researchers	researcher	NOUN
bptjm-57	205	6	usually	usually	ADV
bptjm-57	205	7	use	use	VERB
bptjm-57	205	8	ctc	ctc	NOUN
bptjm-57	205	9	-	-	PUNCT
bptjm-57	205	10	related	relate	VERB
bptjm-57	205	11	technologies	technology	NOUN
bptjm-57	205	12	based	base	VERB
bptjm-57	205	13	on	on	ADP
bptjm-57	205	14	biological	biological	ADJ
bptjm-57	205	15	properties	property	NOUN
bptjm-57	205	16	,	,	PUNCT
bptjm-57	205	17	particularly	particularly	ADV
bptjm-57	205	18	berkeley	berkeley	PROPN
bptjm-57	205	19	pharma	pharma	PROPN
bptjm-57	205	20	tech	tech	NOUN
bptjm-57	205	21	journal	journal	NOUN
bptjm-57	205	22	of	of	ADP
bptjm-57	205	23	medicine	medicine	NOUN
bptjm-57	205	24	|	|	ADV
bptjm-57	205	25	103	103	NUM
bptjm-57	205	26	techniques	technique	NOUN
bptjm-57	205	27	dependent	dependent	ADJ
bptjm-57	205	28	on	on	ADP
bptjm-57	205	29	the	the	DET
bptjm-57	205	30	epithelial	epithelial	ADJ
bptjm-57	205	31	cell	cell	NOUN
bptjm-57	205	32	adhesion	adhesion	NOUN
bptjm-57	205	33	molecule	molecule	NOUN
bptjm-57	205	34	(	(	PUNCT
bptjm-57	205	35	epcam	epcam	NOUN
bptjm-57	205	36	)	)	PUNCT
bptjm-57	205	37	,	,	PUNCT
bptjm-57	205	38	a	a	DET
bptjm-57	205	39	marker	marker	NOUN
bptjm-57	205	40	positively	positively	ADV
bptjm-57	205	41	enriched	enrich	VERB
bptjm-57	205	42	in	in	ADP
bptjm-57	205	43	ctcs.72	ctcs.72	NOUN
bptjm-57	205	44	ctcs	ctcs	PROPN
bptjm-57	205	45	are	be	AUX
bptjm-57	205	46	also	also	ADV
bptjm-57	205	47	indicators	indicator	NOUN
bptjm-57	205	48	of	of	ADP
bptjm-57	205	49	prognosis	prognosis	NOUN
bptjm-57	205	50	and	and	CCONJ
bptjm-57	205	51	a	a	DET
bptjm-57	205	52	non	non	ADJ
bptjm-57	205	53	-	-	ADJ
bptjm-57	205	54	invasive	invasive	ADJ
bptjm-57	205	55	method	method	NOUN
bptjm-57	205	56	of	of	ADP
bptjm-57	205	57	determining	determine	VERB
bptjm-57	205	58	whether	whether	SCONJ
bptjm-57	205	59	a	a	DET
bptjm-57	205	60	treatment	treatment	NOUN
bptjm-57	205	61	is	be	AUX
bptjm-57	205	62	working	work	VERB
bptjm-57	205	63	.	.	PUNCT
bptjm-57	206	1	through	through	ADP
bptjm-57	206	2	liquid	liquid	ADJ
bptjm-57	206	3	biopsies70	biopsies70	NOUN
bptjm-57	206	4	,	,	PUNCT
bptjm-57	206	5	doctors	doctor	NOUN
bptjm-57	206	6	can	can	AUX
bptjm-57	206	7	determine	determine	VERB
bptjm-57	206	8	the	the	DET
bptjm-57	206	9	ctc	ctc	NOUN
bptjm-57	206	10	count	count	NOUN
bptjm-57	206	11	in	in	ADP
bptjm-57	206	12	a	a	DET
bptjm-57	206	13	patient	patient	NOUN
bptjm-57	206	14	’s	’s	PART
bptjm-57	206	15	blood.70	blood.70	PRON
bptjm-57	206	16	in	in	ADP
bptjm-57	206	17	a	a	DET
bptjm-57	206	18	study	study	NOUN
bptjm-57	206	19	that	that	PRON
bptjm-57	206	20	analyzed	analyze	VERB
bptjm-57	206	21	blood	blood	NOUN
bptjm-57	206	22	samples	sample	NOUN
bptjm-57	206	23	from	from	ADP
bptjm-57	206	24	59	59	NUM
bptjm-57	206	25	patients	patient	NOUN
bptjm-57	206	26	with	with	ADP
bptjm-57	206	27	esophageal	esophageal	ADJ
bptjm-57	206	28	squamous	squamous	ADJ
bptjm-57	206	29	cell	cell	NOUN
bptjm-57	206	30	carcinoma	carcinoma	NOUN
bptjm-57	206	31	,	,	PUNCT
bptjm-57	206	32	ctc	ctc	PROPN
bptjm-57	206	33	levels	level	NOUN
bptjm-57	206	34	were	be	AUX
bptjm-57	206	35	found	find	VERB
bptjm-57	206	36	to	to	PART
bptjm-57	206	37	be	be	AUX
bptjm-57	206	38	correlated	correlate	VERB
bptjm-57	206	39	with	with	ADP
bptjm-57	206	40	overall	overall	ADJ
bptjm-57	206	41	survival	survival	NOUN
bptjm-57	206	42	(	(	PUNCT
bptjm-57	206	43	os	os	NOUN
bptjm-57	206	44	)	)	PUNCT
bptjm-57	206	45	and	and	CCONJ
bptjm-57	206	46	pfs	pfs	PROPN
bptjm-57	206	47	rates	rate	NOUN
bptjm-57	206	48	.	.	PUNCT
bptjm-57	207	1	researchers	researcher	NOUN
bptjm-57	207	2	found	find	VERB
bptjm-57	207	3	that	that	SCONJ
bptjm-57	207	4	the	the	DET
bptjm-57	207	5	overall	overall	ADJ
bptjm-57	207	6	and	and	CCONJ
bptjm-57	207	7	progression	progression	NOUN
bptjm-57	207	8	-	-	PUNCT
bptjm-57	207	9	free	free	ADJ
bptjm-57	207	10	survival	survival	NOUN
bptjm-57	207	11	rates	rate	NOUN
bptjm-57	207	12	were	be	AUX
bptjm-57	207	13	signi	signi	ADJ
bptjm-57	207	14	�	�	NOUN
bptjm-57	207	15	cantly	cantly	ADV
bptjm-57	207	16	better	well	ADJ
bptjm-57	207	17	for	for	ADP
bptjm-57	207	18	patients	patient	NOUN
bptjm-57	207	19	with	with	ADP
bptjm-57	207	20	a	a	DET
bptjm-57	207	21	ctc	ctc	NOUN
bptjm-57	207	22	count	count	NOUN
bptjm-57	207	23	of	of	ADP
bptjm-57	207	24	less	less	ADJ
bptjm-57	207	25	than	than	ADP
bptjm-57	207	26	three	three	NUM
bptjm-57	207	27	.	.	PUNCT
bptjm-57	208	1	the	the	DET
bptjm-57	208	2	mortality	mortality	NOUN
bptjm-57	208	3	rates	rate	NOUN
bptjm-57	208	4	for	for	ADP
bptjm-57	208	5	the	the	DET
bptjm-57	208	6	patients	patient	NOUN
bptjm-57	208	7	with	with	ADP
bptjm-57	208	8	either	either	CCONJ
bptjm-57	208	9	>	>	X
bptjm-57	208	10	0	0	NUM
bptjm-57	208	11	,	,	PUNCT
bptjm-57	208	12	>	>	X
bptjm-57	208	13	5	5	NUM
bptjm-57	208	14	,	,	PUNCT
bptjm-57	208	15	and	and	CCONJ
bptjm-57	208	16	>	>	SYM
bptjm-57	208	17	7	7	NUM
bptjm-57	208	18	ctcs	ctcs	NOUN
bptjm-57	208	19	per	per	ADP
bptjm-57	208	20	7.5	7.5	NUM
bptjm-57	208	21	ml	ml	NOUN
bptjm-57	208	22	were	be	AUX
bptjm-57	208	23	65.2	65.2	NUM
bptjm-57	208	24	%	%	NOUN
bptjm-57	208	25	,	,	PUNCT
bptjm-57	208	26	78.4	78.4	NUM
bptjm-57	208	27	%	%	NOUN
bptjm-57	208	28	,	,	PUNCT
bptjm-57	208	29	and	and	CCONJ
bptjm-57	208	30	87.5	87.5	NUM
bptjm-57	208	31	%	%	NOUN
bptjm-57	208	32	respectively.73	respectively.73	VERB
bptjm-57	208	33	a	a	DET
bptjm-57	208	34	lower	low	ADJ
bptjm-57	208	35	ctc	ctc	NOUN
bptjm-57	208	36	count	count	NOUN
bptjm-57	208	37	after	after	ADP
bptjm-57	208	38	treatment	treatment	NOUN
bptjm-57	208	39	is	be	AUX
bptjm-57	208	40	also	also	ADV
bptjm-57	208	41	associated	associate	VERB
bptjm-57	208	42	with	with	ADP
bptjm-57	208	43	an	an	DET
bptjm-57	208	44	excellent	excellent	ADJ
bptjm-57	208	45	prognosis.71,72	prognosis.71,72	NOUN
bptjm-57	208	46	there	there	PRON
bptjm-57	208	47	are	be	VERB
bptjm-57	208	48	also	also	ADV
bptjm-57	208	49	limited	limited	ADJ
bptjm-57	208	50	studies	study	NOUN
bptjm-57	208	51	that	that	PRON
bptjm-57	208	52	suggest	suggest	VERB
bptjm-57	208	53	ctcs	ctcs	NOUN
bptjm-57	208	54	can	can	AUX
bptjm-57	208	55	be	be	AUX
bptjm-57	208	56	used	use	VERB
bptjm-57	208	57	for	for	ADP
bptjm-57	208	58	early	early	ADJ
bptjm-57	208	59	cancer	cancer	NOUN
bptjm-57	208	60	detection	detection	NOUN
bptjm-57	208	61	,	,	PUNCT
bptjm-57	208	62	although	although	SCONJ
bptjm-57	208	63	this	this	PRON
bptjm-57	208	64	has	have	AUX
bptjm-57	208	65	only	only	ADV
bptjm-57	208	66	been	be	AUX
bptjm-57	208	67	shown	show	VERB
bptjm-57	208	68	in	in	ADP
bptjm-57	208	69	mouse	mouse	NOUN
bptjm-57	208	70	models.71	models.71	PROPN
bptjm-57	208	71	4	4	NUM
bptjm-57	208	72	.	.	PUNCT
bptjm-57	209	1	future	future	ADJ
bptjm-57	209	2	directions	direction	NOUN
bptjm-57	209	3	dualor	dualor	VERB
bptjm-57	209	4	multi	multi	NOUN
bptjm-57	209	5	-	-	ADJ
bptjm-57	209	6	eats	eat	NOUN
bptjm-57	209	7	and	and	CCONJ
bptjm-57	209	8	nanornps	nanornps	ADJ
bptjm-57	209	9	with	with	ADP
bptjm-57	209	10	a	a	DET
bptjm-57	209	11	combination	combination	NOUN
bptjm-57	209	12	of	of	ADP
bptjm-57	209	13	sgrnas	sgrna	NOUN
bptjm-57	209	14	have	have	VERB
bptjm-57	209	15	strong	strong	ADJ
bptjm-57	209	16	potential	potential	NOUN
bptjm-57	209	17	to	to	PART
bptjm-57	209	18	confront	confront	VERB
bptjm-57	209	19	therapeutic	therapeutic	ADJ
bptjm-57	209	20	resistance	resistance	NOUN
bptjm-57	209	21	,	,	PUNCT
bptjm-57	209	22	making	make	VERB
bptjm-57	209	23	them	they	PRON
bptjm-57	209	24	promising	promise	VERB
bptjm-57	209	25	improved	improved	ADJ
bptjm-57	209	26	treatment	treatment	NOUN
bptjm-57	209	27	strategies	strategy	NOUN
bptjm-57	209	28	for	for	ADP
bptjm-57	209	29	cancer	cancer	NOUN
bptjm-57	209	30	.	.	PUNCT
bptjm-57	210	1	these	these	DET
bptjm-57	210	2	strategies	strategy	NOUN
bptjm-57	210	3	would	would	AUX
bptjm-57	210	4	also	also	ADV
bptjm-57	210	5	provide	provide	VERB
bptjm-57	210	6	more	more	ADJ
bptjm-57	210	7	insight	insight	NOUN
bptjm-57	210	8	into	into	ADP
bptjm-57	210	9	the	the	DET
bptjm-57	210	10	design	design	NOUN
bptjm-57	210	11	of	of	ADP
bptjm-57	210	12	more	more	ADV
bptjm-57	210	13	advanced	advanced	ADJ
bptjm-57	210	14	and	and	CCONJ
bptjm-57	210	15	e	e	NOUN
bptjm-57	210	16	�	�	NOUN
bptjm-57	210	17	ective	ective	ADJ
bptjm-57	210	18	cancer	cancer	NOUN
bptjm-57	210	19	therapies	therapy	NOUN
bptjm-57	210	20	.	.	PUNCT
bptjm-57	211	1	however	however	ADV
bptjm-57	211	2	,	,	PUNCT
bptjm-57	211	3	they	they	PRON
bptjm-57	211	4	have	have	AUX
bptjm-57	211	5	only	only	ADV
bptjm-57	211	6	been	be	AUX
bptjm-57	211	7	studied	study	VERB
bptjm-57	211	8	in	in	ADP
bptjm-57	211	9	mouse	mouse	NOUN
bptjm-57	211	10	models	model	NOUN
bptjm-57	211	11	and	and	CCONJ
bptjm-57	211	12	heterogeneous	heterogeneous	ADJ
bptjm-57	211	13	tumor	tumor	NOUN
bptjm-57	211	14	models	model	NOUN
bptjm-57	211	15	respectively	respectively	ADV
bptjm-57	211	16	,	,	PUNCT
bptjm-57	211	17	both	both	PRON
bptjm-57	211	18	of	of	ADP
bptjm-57	211	19	which	which	PRON
bptjm-57	211	20	may	may	AUX
bptjm-57	211	21	not	not	PART
bptjm-57	211	22	represent	represent	VERB
bptjm-57	211	23	a	a	DET
bptjm-57	211	24	human	human	ADJ
bptjm-57	211	25	system	system	NOUN
bptjm-57	211	26	perfectly	perfectly	ADV
bptjm-57	211	27	.	.	PUNCT
bptjm-57	212	1	hence	hence	ADV
bptjm-57	212	2	,	,	PUNCT
bptjm-57	212	3	before	before	SCONJ
bptjm-57	212	4	these	these	DET
bptjm-57	212	5	treatments	treatment	NOUN
bptjm-57	212	6	can	can	AUX
bptjm-57	212	7	undergo	undergo	VERB
bptjm-57	212	8	clinical	clinical	ADJ
bptjm-57	212	9	trials	trial	NOUN
bptjm-57	212	10	and	and	CCONJ
bptjm-57	212	11	be	be	AUX
bptjm-57	212	12	used	use	VERB
bptjm-57	212	13	as	as	ADP
bptjm-57	212	14	personalized	personalize	VERB
bptjm-57	212	15	approaches	approach	NOUN
bptjm-57	212	16	for	for	ADP
bptjm-57	212	17	tumor	tumor	NOUN
bptjm-57	212	18	heterogeneity	heterogeneity	NOUN
bptjm-57	212	19	,	,	PUNCT
bptjm-57	212	20	more	more	ADJ
bptjm-57	212	21	research	research	NOUN
bptjm-57	212	22	must	must	AUX
bptjm-57	212	23	be	be	AUX
bptjm-57	212	24	conducted	conduct	VERB
bptjm-57	212	25	to	to	PART
bptjm-57	212	26	ensure	ensure	VERB
bptjm-57	212	27	that	that	DET
bptjm-57	212	28	side	side	NOUN
bptjm-57	212	29	e	e	NOUN
bptjm-57	212	30	�	�	NOUN
bptjm-57	212	31	ects	ect	NOUN
bptjm-57	212	32	,	,	PUNCT
bptjm-57	212	33	such	such	ADJ
bptjm-57	212	34	as	as	ADP
bptjm-57	212	35	o	o	NOUN
bptjm-57	212	36	�	�	NOUN
bptjm-57	212	37	-target	-target	NOUN
bptjm-57	212	38	toxicities	toxicity	NOUN
bptjm-57	212	39	,	,	PUNCT
bptjm-57	212	40	are	be	AUX
bptjm-57	212	41	minimized.67,69	minimized.67,69	VERB
bptjm-57	212	42	on	on	ADP
bptjm-57	212	43	another	another	DET
bptjm-57	212	44	note	note	NOUN
bptjm-57	212	45	,	,	PUNCT
bptjm-57	212	46	further	further	ADJ
bptjm-57	212	47	research	research	NOUN
bptjm-57	212	48	on	on	ADP
bptjm-57	212	49	optimizing	optimize	VERB
bptjm-57	212	50	models	model	NOUN
bptjm-57	212	51	to	to	PART
bptjm-57	212	52	better	well	ADV
bptjm-57	212	53	imitate	imitate	VERB
bptjm-57	212	54	human	human	ADJ
bptjm-57	212	55	diseases	disease	NOUN
bptjm-57	212	56	would	would	AUX
bptjm-57	212	57	undoubtedly	undoubtedly	ADV
bptjm-57	212	58	be	be	AUX
bptjm-57	212	59	useful	useful	ADJ
bptjm-57	212	60	for	for	ADP
bptjm-57	212	61	preclinical	preclinical	ADJ
bptjm-57	212	62	testing	testing	NOUN
bptjm-57	212	63	of	of	ADP
bptjm-57	212	64	the	the	DET
bptjm-57	212	65	safety	safety	NOUN
bptjm-57	212	66	and	and	CCONJ
bptjm-57	212	67	e	e	NOUN
bptjm-57	212	68	�	�	NOUN
bptjm-57	212	69	cacy	cacy	NOUN
bptjm-57	212	70	of	of	ADP
bptjm-57	212	71	drugs	drug	NOUN
bptjm-57	212	72	and	and	CCONJ
bptjm-57	212	73	treatment	treatment	NOUN
bptjm-57	212	74	strategies	strategy	NOUN
bptjm-57	212	75	.	.	PUNCT
bptjm-57	213	1	ctcs	ctcs	ADJ
bptjm-57	213	2	,	,	PUNCT
bptjm-57	213	3	in	in	ADP
bptjm-57	213	4	turn	turn	NOUN
bptjm-57	213	5	,	,	PUNCT
bptjm-57	213	6	are	be	AUX
bptjm-57	213	7	promising	promise	VERB
bptjm-57	213	8	as	as	ADP
bptjm-57	213	9	a	a	DET
bptjm-57	213	10	way	way	NOUN
bptjm-57	213	11	to	to	PART
bptjm-57	213	12	determine	determine	VERB
bptjm-57	213	13	the	the	DET
bptjm-57	213	14	progress	progress	NOUN
bptjm-57	213	15	and	and	CCONJ
bptjm-57	213	16	clinical	clinical	ADJ
bptjm-57	213	17	e	e	NOUN
bptjm-57	213	18	�	�	NOUN
bptjm-57	213	19	ciency	ciency	NOUN
bptjm-57	213	20	of	of	ADP
bptjm-57	213	21	a	a	DET
bptjm-57	213	22	treatment	treatment	NOUN
bptjm-57	213	23	.	.	PUNCT
bptjm-57	214	1	the	the	DET
bptjm-57	214	2	ctc	ctc	PROPN
bptjm-57	214	3	count	count	NOUN
bptjm-57	214	4	can	can	AUX
bptjm-57	214	5	be	be	AUX
bptjm-57	214	6	used	use	VERB
bptjm-57	214	7	as	as	ADP
bptjm-57	214	8	an	an	DET
bptjm-57	214	9	indicator	indicator	NOUN
bptjm-57	214	10	that	that	PRON
bptjm-57	214	11	a	a	DET
bptjm-57	214	12	treatment	treatment	NOUN
bptjm-57	214	13	is	be	AUX
bptjm-57	214	14	no	no	ADV
bptjm-57	214	15	longer	long	ADV
bptjm-57	214	16	e	e	NOUN
bptjm-57	214	17	�	�	NOUN
bptjm-57	214	18	ective	ective	ADJ
bptjm-57	214	19	,	,	PUNCT
bptjm-57	214	20	triggering	trigger	VERB
bptjm-57	214	21	a	a	DET
bptjm-57	214	22	change	change	NOUN
bptjm-57	214	23	in	in	ADP
bptjm-57	214	24	the	the	DET
bptjm-57	214	25	type	type	NOUN
bptjm-57	214	26	of	of	ADP
bptjm-57	214	27	therapy	therapy	NOUN
bptjm-57	214	28	a	a	DET
bptjm-57	214	29	patient	patient	NOUN
bptjm-57	214	30	is	be	AUX
bptjm-57	214	31	receiving	receive	VERB
bptjm-57	214	32	.	.	PUNCT
bptjm-57	215	1	since	since	SCONJ
bptjm-57	215	2	a	a	DET
bptjm-57	215	3	key	key	ADJ
bptjm-57	215	4	challenge	challenge	NOUN
bptjm-57	215	5	is	be	AUX
bptjm-57	215	6	the	the	DET
bptjm-57	215	7	rarity	rarity	NOUN
bptjm-57	215	8	of	of	ADP
bptjm-57	215	9	ctcs	ctcs	NOUN
bptjm-57	215	10	,	,	PUNCT
bptjm-57	215	11	more	more	ADJ
bptjm-57	215	12	research	research	NOUN
bptjm-57	215	13	has	have	VERB
bptjm-57	215	14	to	to	PART
bptjm-57	215	15	be	be	AUX
bptjm-57	215	16	done	do	VERB
bptjm-57	215	17	to	to	ADP
bptjm-57	215	18	�	�	PROPN
bptjm-57	215	19	nd	nd	NUM
bptjm-57	215	20	ways	way	NOUN
bptjm-57	215	21	to	to	PART
bptjm-57	215	22	identify	identify	VERB
bptjm-57	215	23	and	and	CCONJ
bptjm-57	215	24	isolate	isolate	VERB
bptjm-57	215	25	ctcs	ctcs	NOUN
bptjm-57	215	26	.	.	PUNCT
bptjm-57	216	1	this	this	DET
bptjm-57	216	2	berkeley	berkeley	PROPN
bptjm-57	216	3	pharma	pharma	PROPN
bptjm-57	216	4	tech	tech	NOUN
bptjm-57	216	5	journal	journal	NOUN
bptjm-57	216	6	of	of	ADP
bptjm-57	216	7	medicine	medicine	NOUN
bptjm-57	216	8	|	|	ADV
bptjm-57	216	9	104	104	NUM
bptjm-57	216	10	could	could	AUX
bptjm-57	216	11	then	then	ADV
bptjm-57	216	12	contribute	contribute	VERB
bptjm-57	216	13	to	to	ADP
bptjm-57	216	14	a	a	DET
bptjm-57	216	15	larger	large	ADJ
bptjm-57	216	16	sample	sample	NOUN
bptjm-57	216	17	size	size	NOUN
bptjm-57	216	18	that	that	PRON
bptjm-57	216	19	can	can	AUX
bptjm-57	216	20	be	be	AUX
bptjm-57	216	21	used	use	VERB
bptjm-57	216	22	in	in	ADP
bptjm-57	216	23	studies	study	NOUN
bptjm-57	216	24	,	,	PUNCT
bptjm-57	216	25	improving	improve	VERB
bptjm-57	216	26	their	their	PRON
bptjm-57	216	27	reliability.70	reliability.70	NOUN
bptjm-57	216	28	the	the	DET
bptjm-57	216	29	emerging	emerge	VERB
bptjm-57	216	30	technologies	technology	NOUN
bptjm-57	216	31	and	and	CCONJ
bptjm-57	216	32	methodologies	methodology	NOUN
bptjm-57	216	33	for	for	ADP
bptjm-57	216	34	assessing	assess	VERB
bptjm-57	216	35	tumor	tumor	NOUN
bptjm-57	216	36	heterogeneity	heterogeneity	NOUN
bptjm-57	216	37	are	be	AUX
bptjm-57	216	38	clear	clear	ADJ
bptjm-57	216	39	implications	implication	NOUN
bptjm-57	216	40	of	of	ADP
bptjm-57	216	41	the	the	DET
bptjm-57	216	42	advancement	advancement	NOUN
bptjm-57	216	43	of	of	ADP
bptjm-57	216	44	personalized	personalized	ADJ
bptjm-57	216	45	treatment	treatment	NOUN
bptjm-57	216	46	and	and	CCONJ
bptjm-57	216	47	precision	precision	NOUN
bptjm-57	216	48	targeting	target	VERB
bptjm-57	216	49	for	for	ADP
bptjm-57	216	50	heterogeneous	heterogeneous	ADJ
bptjm-57	216	51	tumors	tumor	NOUN
bptjm-57	216	52	.	.	PUNCT
bptjm-57	217	1	currently	currently	ADV
bptjm-57	217	2	,	,	PUNCT
bptjm-57	217	3	novel	novel	ADJ
bptjm-57	217	4	targets	target	NOUN
bptjm-57	217	5	and	and	CCONJ
bptjm-57	217	6	therapeutic	therapeutic	ADJ
bptjm-57	217	7	strategies	strategy	NOUN
bptjm-57	217	8	for	for	ADP
bptjm-57	217	9	overcoming	overcome	VERB
bptjm-57	217	10	tumor	tumor	NOUN
bptjm-57	217	11	heterogeneity	heterogeneity	NOUN
bptjm-57	217	12	are	be	AUX
bptjm-57	217	13	critical	critical	ADJ
bptjm-57	217	14	in	in	ADP
bptjm-57	217	15	cancer	cancer	NOUN
bptjm-57	217	16	research	research	NOUN
bptjm-57	217	17	.	.	PUNCT
bptjm-57	218	1	cancer	cancer	NOUN
bptjm-57	218	2	research	research	NOUN
bptjm-57	218	3	is	be	AUX
bptjm-57	218	4	extremely	extremely	ADV
bptjm-57	218	5	complicated	complicated	ADJ
bptjm-57	218	6	and	and	CCONJ
bptjm-57	218	7	unique	unique	ADJ
bptjm-57	218	8	because	because	SCONJ
bptjm-57	218	9	each	each	DET
bptjm-57	218	10	type	type	NOUN
bptjm-57	218	11	of	of	ADP
bptjm-57	218	12	cancer	cancer	NOUN
bptjm-57	218	13	for	for	ADP
bptjm-57	218	14	every	every	DET
bptjm-57	218	15	individual	individual	NOUN
bptjm-57	218	16	is	be	AUX
bptjm-57	218	17	di	di	NOUN
bptjm-57	218	18	�	�	PROPN
bptjm-57	218	19	erent	erent	NOUN
bptjm-57	218	20	,	,	PUNCT
bptjm-57	218	21	one	one	NUM
bptjm-57	218	22	factor	factor	NOUN
bptjm-57	218	23	of	of	ADP
bptjm-57	218	24	which	which	PRON
bptjm-57	218	25	is	be	AUX
bptjm-57	218	26	tumor	tumor	NOUN
bptjm-57	218	27	heterogeneity	heterogeneity	NOUN
bptjm-57	218	28	.	.	PUNCT
bptjm-57	219	1	this	this	PRON
bptjm-57	219	2	poses	pose	VERB
bptjm-57	219	3	a	a	DET
bptjm-57	219	4	major	major	ADJ
bptjm-57	219	5	barrier	barrier	NOUN
bptjm-57	219	6	to	to	ADP
bptjm-57	219	7	producing	produce	VERB
bptjm-57	219	8	a	a	DET
bptjm-57	219	9	generalized	generalized	ADJ
bptjm-57	219	10	approach	approach	NOUN
bptjm-57	219	11	and	and	CCONJ
bptjm-57	219	12	treatment	treatment	NOUN
bptjm-57	219	13	for	for	ADP
bptjm-57	219	14	all	all	DET
bptjm-57	219	15	individuals	individual	NOUN
bptjm-57	219	16	su	su	PROPN
bptjm-57	219	17	�	�	PROPN
bptjm-57	219	18	ering	ere	VERB
bptjm-57	219	19	from	from	ADP
bptjm-57	219	20	this	this	DET
bptjm-57	219	21	disease	disease	NOUN
bptjm-57	219	22	.	.	PUNCT
bptjm-57	220	1	because	because	SCONJ
bptjm-57	220	2	tumors	tumor	NOUN
bptjm-57	220	3	possess	possess	VERB
bptjm-57	220	4	the	the	DET
bptjm-57	220	5	capability	capability	NOUN
bptjm-57	220	6	to	to	PART
bptjm-57	220	7	overcome	overcome	VERB
bptjm-57	220	8	therapeutics	therapeutic	NOUN
bptjm-57	220	9	and	and	CCONJ
bptjm-57	220	10	treatments	treatment	NOUN
bptjm-57	220	11	,	,	PUNCT
bptjm-57	220	12	scientists	scientist	NOUN
bptjm-57	220	13	and	and	CCONJ
bptjm-57	220	14	medical	medical	ADJ
bptjm-57	220	15	researchers	researcher	NOUN
bptjm-57	220	16	are	be	AUX
bptjm-57	220	17	constantly	constantly	ADV
bptjm-57	220	18	faced	face	VERB
bptjm-57	220	19	with	with	ADP
bptjm-57	220	20	new	new	ADJ
bptjm-57	220	21	challenges	challenge	NOUN
bptjm-57	220	22	in	in	ADP
bptjm-57	220	23	producing	produce	VERB
bptjm-57	220	24	a	a	DET
bptjm-57	220	25	cure	cure	NOUN
bptjm-57	220	26	for	for	ADP
bptjm-57	220	27	cancer	cancer	NOUN
bptjm-57	220	28	.	.	PUNCT
bptjm-57	221	1	on	on	ADP
bptjm-57	221	2	the	the	DET
bptjm-57	221	3	other	other	ADJ
bptjm-57	221	4	hand	hand	NOUN
bptjm-57	221	5	,	,	PUNCT
bptjm-57	221	6	novel	novel	ADJ
bptjm-57	221	7	techniques	technique	NOUN
bptjm-57	221	8	that	that	PRON
bptjm-57	221	9	analyze	analyze	VERB
bptjm-57	221	10	individual	individual	ADJ
bptjm-57	221	11	cells	cell	NOUN
bptjm-57	221	12	and	and	CCONJ
bptjm-57	221	13	their	their	PRON
bptjm-57	221	14	distribution	distribution	NOUN
bptjm-57	221	15	,	,	PUNCT
bptjm-57	221	16	such	such	ADJ
bptjm-57	221	17	as	as	ADP
bptjm-57	221	18	single	single	ADJ
bptjm-57	221	19	-	-	PUNCT
bptjm-57	221	20	cell	cell	NOUN
bptjm-57	221	21	sequencing	sequencing	NOUN
bptjm-57	221	22	and	and	CCONJ
bptjm-57	221	23	spatial	spatial	ADJ
bptjm-57	221	24	transcriptomics	transcriptomic	NOUN
bptjm-57	221	25	,	,	PUNCT
bptjm-57	221	26	have	have	AUX
bptjm-57	221	27	transformed	transform	VERB
bptjm-57	221	28	our	our	PRON
bptjm-57	221	29	predictive	predictive	ADJ
bptjm-57	221	30	value	value	NOUN
bptjm-57	221	31	and	and	CCONJ
bptjm-57	221	32	comprehension	comprehension	NOUN
bptjm-57	221	33	of	of	ADP
bptjm-57	221	34	the	the	DET
bptjm-57	221	35	complex	complex	ADJ
bptjm-57	221	36	cellular	cellular	ADJ
bptjm-57	221	37	organization.74,75	organization.74,75	NOUN
bptjm-57	221	38	all	all	PRON
bptjm-57	221	39	of	of	ADP
bptjm-57	221	40	the	the	DET
bptjm-57	221	41	mentioned	mention	VERB
bptjm-57	221	42	novel	novel	NOUN
bptjm-57	221	43	technologies	technology	NOUN
bptjm-57	221	44	and	and	CCONJ
bptjm-57	221	45	ongoing	ongoing	ADJ
bptjm-57	221	46	clinical	clinical	ADJ
bptjm-57	221	47	trials	trial	NOUN
bptjm-57	221	48	pave	pave	VERB
bptjm-57	221	49	a	a	DET
bptjm-57	221	50	clearer	clear	ADJ
bptjm-57	221	51	path	path	NOUN
bptjm-57	221	52	toward	toward	ADP
bptjm-57	221	53	�	�	NOUN
bptjm-57	221	54	nding	nde	VERB
bptjm-57	221	55	a	a	DET
bptjm-57	221	56	more	more	ADJ
bptjm-57	221	57	target	target	NOUN
bptjm-57	221	58	-	-	PUNCT
bptjm-57	221	59	speci	speci	NOUN
bptjm-57	221	60	�	�	PROPN
bptjm-57	221	61	c	c	NOUN
bptjm-57	221	62	treatment	treatment	NOUN
bptjm-57	221	63	for	for	ADP
bptjm-57	221	64	cancer	cancer	NOUN
bptjm-57	221	65	.	.	PUNCT
bptjm-57	222	1	once	once	SCONJ
bptjm-57	222	2	tumor	tumor	NOUN
bptjm-57	222	3	heterogeneity	heterogeneity	NOUN
bptjm-57	222	4	is	be	AUX
bptjm-57	222	5	addressed	address	VERB
bptjm-57	222	6	,	,	PUNCT
bptjm-57	222	7	research	research	NOUN
bptjm-57	222	8	can	can	AUX
bptjm-57	222	9	focus	focus	VERB
bptjm-57	222	10	on	on	ADP
bptjm-57	222	11	other	other	ADJ
bptjm-57	222	12	complex	complex	ADJ
bptjm-57	222	13	aspects	aspect	NOUN
bptjm-57	222	14	of	of	ADP
bptjm-57	222	15	cancer	cancer	NOUN
bptjm-57	222	16	treatment	treatment	NOUN
bptjm-57	222	17	.	.	PUNCT
bptjm-57	223	1	5	5	X
bptjm-57	223	2	.	.	X
bptjm-57	223	3	conclusion	conclusion	NOUN
bptjm-57	223	4	tumor	tumor	NOUN
bptjm-57	223	5	heterogeneity	heterogeneity	NOUN
bptjm-57	223	6	is	be	AUX
bptjm-57	223	7	the	the	DET
bptjm-57	223	8	largest	large	ADJ
bptjm-57	223	9	barrier	barrier	NOUN
bptjm-57	223	10	in	in	ADP
bptjm-57	223	11	developing	develop	VERB
bptjm-57	223	12	ground	ground	NOUN
bptjm-57	223	13	-	-	PUNCT
bptjm-57	223	14	breaking	break	VERB
bptjm-57	223	15	and	and	CCONJ
bptjm-57	223	16	target	target	NOUN
bptjm-57	223	17	-	-	PUNCT
bptjm-57	223	18	speci	speci	NOUN
bptjm-57	223	19	�	�	PROPN
bptjm-57	223	20	c	c	NOUN
bptjm-57	223	21	cancer	cancer	NOUN
bptjm-57	223	22	treatments	treatment	NOUN
bptjm-57	223	23	.	.	PUNCT
bptjm-57	224	1	with	with	ADP
bptjm-57	224	2	therapeutic	therapeutic	ADJ
bptjm-57	224	3	resistance	resistance	NOUN
bptjm-57	224	4	forming	form	VERB
bptjm-57	224	5	among	among	ADP
bptjm-57	224	6	all	all	DET
bptjm-57	224	7	forms	form	NOUN
bptjm-57	224	8	of	of	ADP
bptjm-57	224	9	cancer	cancer	NOUN
bptjm-57	224	10	,	,	PUNCT
bptjm-57	224	11	tumor	tumor	NOUN
bptjm-57	224	12	heterogeneity	heterogeneity	NOUN
bptjm-57	224	13	highlights	highlight	VERB
bptjm-57	224	14	the	the	DET
bptjm-57	224	15	need	need	NOUN
bptjm-57	224	16	for	for	ADP
bptjm-57	224	17	novel	novel	ADJ
bptjm-57	224	18	treatments	treatment	NOUN
bptjm-57	224	19	that	that	PRON
bptjm-57	224	20	will	will	AUX
bptjm-57	224	21	overcome	overcome	VERB
bptjm-57	224	22	this	this	DET
bptjm-57	224	23	barrier	barrier	NOUN
bptjm-57	224	24	.	.	PUNCT
bptjm-57	225	1	current	current	ADJ
bptjm-57	225	2	therapies	therapy	NOUN
bptjm-57	225	3	that	that	PRON
bptjm-57	225	4	can	can	AUX
bptjm-57	225	5	limit	limit	VERB
bptjm-57	225	6	cancer	cancer	NOUN
bptjm-57	225	7	disease	disease	NOUN
bptjm-57	225	8	progression	progression	NOUN
bptjm-57	225	9	include	include	VERB
bptjm-57	225	10	immunotherapy	immunotherapy	NOUN
bptjm-57	225	11	,	,	PUNCT
bptjm-57	225	12	particularly	particularly	ADV
bptjm-57	225	13	car	car	NOUN
bptjm-57	225	14	-	-	PUNCT
bptjm-57	225	15	t	t	NOUN
bptjm-57	225	16	cell	cell	NOUN
bptjm-57	225	17	therapy	therapy	NOUN
bptjm-57	225	18	,	,	PUNCT
bptjm-57	225	19	and	and	CCONJ
bptjm-57	225	20	combination	combination	NOUN
bptjm-57	225	21	therapy	therapy	NOUN
bptjm-57	225	22	.	.	PUNCT
bptjm-57	226	1	there	there	PRON
bptjm-57	226	2	are	be	VERB
bptjm-57	226	3	also	also	ADV
bptjm-57	226	4	novel	novel	ADJ
bptjm-57	226	5	strategies	strategy	NOUN
bptjm-57	226	6	,	,	PUNCT
bptjm-57	226	7	such	such	ADJ
bptjm-57	226	8	as	as	ADP
bptjm-57	226	9	dualor	dualor	NOUN
bptjm-57	226	10	multi	multi	NOUN
bptjm-57	226	11	-	-	ADJ
bptjm-57	226	12	eats	eat	NOUN
bptjm-57	226	13	,	,	PUNCT
bptjm-57	226	14	nanornps	nanornps	ADV
bptjm-57	226	15	with	with	ADP
bptjm-57	226	16	a	a	DET
bptjm-57	226	17	combination	combination	NOUN
bptjm-57	226	18	of	of	ADP
bptjm-57	226	19	sgrnas	sgrna	NOUN
bptjm-57	226	20	,	,	PUNCT
bptjm-57	226	21	and	and	CCONJ
bptjm-57	226	22	ctcs	ctcs	NOUN
bptjm-57	226	23	.	.	PUNCT
bptjm-57	227	1	each	each	DET
bptjm-57	227	2	strategy	strategy	NOUN
bptjm-57	227	3	presents	present	VERB
bptjm-57	227	4	their	their	PRON
bptjm-57	227	5	own	own	ADJ
bptjm-57	227	6	respective	respective	ADJ
bptjm-57	227	7	challenges	challenge	NOUN
bptjm-57	227	8	that	that	PRON
bptjm-57	227	9	limit	limit	VERB
bptjm-57	227	10	them	they	PRON
bptjm-57	227	11	to	to	PART
bptjm-57	227	12	mouse	mouse	NOUN
bptjm-57	227	13	model	model	NOUN
bptjm-57	227	14	studies	study	NOUN
bptjm-57	227	15	or	or	CCONJ
bptjm-57	227	16	insu	insu	PROPN
bptjm-57	227	17	�	�	PROPN
bptjm-57	227	18	cient	cient	PROPN
bptjm-57	227	19	target	target	NOUN
bptjm-57	227	20	gene	gene	NOUN
bptjm-57	227	21	reduction	reduction	NOUN
bptjm-57	227	22	.	.	PUNCT
bptjm-57	228	1	ongoing	ongoing	ADJ
bptjm-57	228	2	clinical	clinical	ADJ
bptjm-57	228	3	trials	trial	NOUN
bptjm-57	228	4	exist	exist	VERB
bptjm-57	228	5	to	to	PART
bptjm-57	228	6	reduce	reduce	VERB
bptjm-57	228	7	such	such	ADJ
bptjm-57	228	8	limitations	limitation	NOUN
bptjm-57	228	9	and	and	CCONJ
bptjm-57	228	10	challenges	challenge	NOUN
bptjm-57	228	11	and	and	CCONJ
bptjm-57	228	12	discover	discover	VERB
bptjm-57	228	13	crucial	crucial	ADJ
bptjm-57	228	14	information	information	NOUN
bptjm-57	228	15	for	for	ADP
bptjm-57	228	16	the	the	DET
bptjm-57	228	17	treatment	treatment	NOUN
bptjm-57	228	18	of	of	ADP
bptjm-57	228	19	humans	human	NOUN
bptjm-57	228	20	.	.	PUNCT
bptjm-57	229	1	since	since	SCONJ
bptjm-57	229	2	no	no	DET
bptjm-57	229	3	single	single	ADJ
bptjm-57	229	4	treatment	treatment	NOUN
bptjm-57	229	5	has	have	AUX
bptjm-57	229	6	yet	yet	ADV
bptjm-57	229	7	been	be	AUX
bptjm-57	229	8	discovered	discover	VERB
bptjm-57	229	9	to	to	PART
bptjm-57	229	10	completely	completely	ADV
bptjm-57	229	11	overcome	overcome	VERB
bptjm-57	229	12	berkeley	berkeley	PROPN
bptjm-57	229	13	pharma	pharma	PROPN
bptjm-57	229	14	tech	tech	NOUN
bptjm-57	229	15	journal	journal	NOUN
bptjm-57	229	16	of	of	ADP
bptjm-57	229	17	medicine	medicine	NOUN
bptjm-57	230	1	|	|	ADV
bptjm-57	230	2	105	105	NUM
bptjm-57	230	3	tumor	tumor	NOUN
bptjm-57	230	4	heterogeneity	heterogeneity	NOUN
bptjm-57	230	5	,	,	PUNCT
bptjm-57	230	6	medical	medical	ADJ
bptjm-57	230	7	research	research	NOUN
bptjm-57	230	8	in	in	ADP
bptjm-57	230	9	developing	develop	VERB
bptjm-57	230	10	personalized	personalized	ADJ
bptjm-57	230	11	treatment	treatment	NOUN
bptjm-57	230	12	and	and	CCONJ
bptjm-57	230	13	precision	precision	NOUN
bptjm-57	230	14	targeting	target	VERB
bptjm-57	230	15	is	be	AUX
bptjm-57	230	16	thus	thus	ADV
bptjm-57	230	17	vital	vital	ADJ
bptjm-57	230	18	in	in	ADP
bptjm-57	230	19	saving	save	VERB
bptjm-57	230	20	lives	life	NOUN
bptjm-57	230	21	.	.	PUNCT
bptjm-57	231	1	berkeley	berkeley	PROPN
bptjm-57	231	2	pharma	pharma	PROPN
bptjm-57	231	3	tech	tech	PROPN
bptjm-57	231	4	journal	journal	NOUN
bptjm-57	231	5	of	of	ADP
bptjm-57	231	6	medicine	medicine	NOUN
bptjm-57	231	7	|	|	ADV
bptjm-57	231	8	106	106	NUM
bptjm-57	231	9	references	reference	NOUN
bptjm-57	231	10	1	1	NUM
bptjm-57	231	11	.	.	PUNCT
bptjm-57	232	1	ahmad	ahmad	PROPN
bptjm-57	232	2	fb	fb	PROPN
bptjm-57	232	3	,	,	PUNCT
bptjm-57	232	4	cisewski	cisewski	VERB
bptjm-57	232	5	ja	ja	PROPN
bptjm-57	232	6	,	,	PUNCT
bptjm-57	233	1	xu	xu	PROPN
bptjm-57	233	2	j	j	PROPN
bptjm-57	233	3	,	,	PUNCT
bptjm-57	233	4	anderson	anderson	PROPN
bptjm-57	233	5	rn	rn	PROPN
bptjm-57	233	6	.	.	PROPN
bptjm-57	233	7	provisional	provisional	ADJ
bptjm-57	233	8	mortality	mortality	NOUN
bptjm-57	233	9	data	datum	NOUN
bptjm-57	233	10	—	—	PUNCT
bptjm-57	233	11	united	united	PROPN
bptjm-57	233	12	states	states	PROPN
bptjm-57	233	13	,	,	PUNCT
bptjm-57	233	14	2022.mmwrmorbmortalwkly	2022.mmwrmorbmortalwkly	ADV
bptjm-57	233	15	rep	rep	PROPN
bptjm-57	233	16	.	.	PROPN
bptjm-57	233	17	2023;72(18):488	2023;72(18):488	PROPN
bptjm-57	233	18	-	-	PUNCT
bptjm-57	233	19	492	492	NUM
bptjm-57	233	20	.	.	PUNCT
bptjm-57	234	1	doi:10.15585	doi:10.15585	PROPN
bptjm-57	234	2	/	/	SYM
bptjm-57	234	3	mmwr.mm7218a3	mmwr.mm7218a3	NOUN
bptjm-57	234	4	.	.	PUNCT
bptjm-57	235	1	2	2	NUM
bptjm-57	235	2	.	.	X
bptjm-57	235	3	common	common	ADJ
bptjm-57	235	4	cancer	cancer	NOUN
bptjm-57	235	5	sites	site	NOUN
bptjm-57	235	6	cancer	cancer	NOUN
bptjm-57	235	7	stat	stat	PROPN
bptjm-57	235	8	facts	fact	VERB
bptjm-57	235	9	.	.	PUNCT
bptjm-57	236	1	national	national	PROPN
bptjm-57	236	2	cancer	cancer	PROPN
bptjm-57	236	3	institute	institute	PROPN
bptjm-57	236	4	.	.	PUNCT
bptjm-57	237	1	accessed	access	VERB
bptjm-57	237	2	july	july	PROPN
bptjm-57	237	3	17	17	NUM
bptjm-57	237	4	,	,	PUNCT
bptjm-57	237	5	2023	2023	NUM
bptjm-57	237	6	.	.	PUNCT
bptjm-57	238	1	https://seer.cancer.gov/statfacts/html/common	https://seer.cancer.gov/statfacts/html/common	PROPN
bptjm-57	238	2	.	.	PUNCT
bptjm-57	238	3	html	html	PROPN
bptjm-57	238	4	.	.	PUNCT
bptjm-57	239	1	3	3	X
bptjm-57	239	2	.	.	X
bptjm-57	239	3	common	common	ADJ
bptjm-57	239	4	cancer	cancer	NOUN
bptjm-57	239	5	types	type	NOUN
bptjm-57	239	6	.	.	PUNCT
bptjm-57	240	1	national	national	PROPN
bptjm-57	240	2	cancer	cancer	PROPN
bptjm-57	240	3	institute	institute	PROPN
bptjm-57	240	4	.	.	PUNCT
bptjm-57	241	1	accessed	access	VERB
bptjm-57	241	2	july	july	PROPN
bptjm-57	241	3	17	17	NUM
bptjm-57	241	4	,	,	PUNCT
bptjm-57	241	5	2023	2023	NUM
bptjm-57	241	6	.	.	PUNCT
bptjm-57	242	1	https://www.cancer.gov/types/common-cancers	https://www.cancer.gov/types/common-cancer	NOUN
bptjm-57	242	2	.	.	PUNCT
bptjm-57	243	1	4	4	X
bptjm-57	243	2	.	.	X
bptjm-57	244	1	what	what	PRON
bptjm-57	244	2	is	be	AUX
bptjm-57	244	3	cancer	cancer	NOUN
bptjm-57	244	4	?	?	PUNCT
bptjm-57	244	5	.	.	PUNCT
bptjm-57	245	1	national	national	PROPN
bptjm-57	245	2	cancer	cancer	PROPN
bptjm-57	245	3	institute	institute	PROPN
bptjm-57	245	4	.	.	PUNCT
bptjm-57	246	1	accessed	access	VERB
bptjm-57	246	2	july	july	PROPN
bptjm-57	246	3	17	17	NUM
bptjm-57	246	4	,	,	PUNCT
bptjm-57	246	5	2023	2023	NUM
bptjm-57	246	6	.	.	PUNCT
bptjm-57	247	1	https://www.cancer.gov/about-cancer/unders	https://www.cancer.gov/about-cancer/under	NOUN
bptjm-57	247	2	tanding	tande	VERB
bptjm-57	247	3	/	/	SYM
bptjm-57	247	4	what	what	PRON
bptjm-57	247	5	-	-	PUNCT
bptjm-57	247	6	is	be	AUX
bptjm-57	247	7	-	-	PUNCT
bptjm-57	247	8	cancer	cancer	NOUN
bptjm-57	247	9	.	.	PUNCT
bptjm-57	248	1	5	5	X
bptjm-57	248	2	.	.	X
bptjm-57	248	3	alexandrov	alexandrov	PROPN
bptjm-57	248	4	lb	lb	PROPN
bptjm-57	248	5	,	,	PUNCT
bptjm-57	248	6	nik	nik	PROPN
bptjm-57	248	7	-	-	PROPN
bptjm-57	248	8	zainal	zainal	ADJ
bptjm-57	248	9	s	s	PROPN
bptjm-57	248	10	,	,	PUNCT
bptjm-57	248	11	wedge	wedge	NOUN
bptjm-57	248	12	dc	dc	PROPN
bptjm-57	248	13	,	,	PUNCT
bptjm-57	248	14	et	et	PROPN
bptjm-57	248	15	al	al	PROPN
bptjm-57	248	16	.	.	PROPN
bptjm-57	248	17	signatures	signature	NOUN
bptjm-57	248	18	of	of	ADP
bptjm-57	248	19	mutational	mutational	ADJ
bptjm-57	248	20	processes	process	NOUN
bptjm-57	248	21	in	in	ADP
bptjm-57	248	22	human	human	ADJ
bptjm-57	248	23	cancer	cancer	NOUN
bptjm-57	248	24	[	[	X
bptjm-57	248	25	published	publish	VERB
bptjm-57	248	26	correction	correction	NOUN
bptjm-57	248	27	appears	appear	VERB
bptjm-57	248	28	in	in	ADP
bptjm-57	248	29	nature	nature	NOUN
bptjm-57	248	30	.	.	PUNCT
bptjm-57	249	1	2013	2013	NUM
bptjm-57	249	2	oct	oct	NOUN
bptjm-57	249	3	10;502(7470):258	10;502(7470):258	NUM
bptjm-57	249	4	.	.	PUNCT
bptjm-57	250	1	imielinsk	imielinsk	PROPN
bptjm-57	250	2	,	,	PUNCT
bptjm-57	250	3	marcin	marcin	PROPN
bptjm-57	250	4	[	[	X
bptjm-57	250	5	corrected	correct	VERB
bptjm-57	250	6	to	to	PART
bptjm-57	250	7	imielinski	imielinski	VERB
bptjm-57	250	8	,	,	PUNCT
bptjm-57	250	9	marcin]].nature	marcin]].nature	NOUN
bptjm-57	250	10	.	.	PROPN
bptjm-57	250	11	2013;500(7463):415	2013;500(7463):415	NUM
bptjm-57	250	12	-	-	SYM
bptjm-57	250	13	421	421	NUM
bptjm-57	250	14	.	.	PUNCT
bptjm-57	251	1	doi:10.1038	doi:10.1038	NOUN
bptjm-57	251	2	/	/	SYM
bptjm-57	251	3	nature12477	nature12477	PROPN
bptjm-57	251	4	.	.	PUNCT
bptjm-57	252	1	6	6	NUM
bptjm-57	252	2	.	.	X
bptjm-57	252	3	anchang	anchang	PROPN
bptjm-57	252	4	b	b	PROPN
bptjm-57	252	5	,	,	PUNCT
bptjm-57	252	6	domt	domt	PROPN
bptjm-57	252	7	,	,	PUNCT
bptjm-57	252	8	zhao	zhao	PROPN
bptjm-57	252	9	x	x	PROPN
bptjm-57	252	10	,	,	PUNCT
bptjm-57	252	11	plevritis	plevritis	NOUN
bptjm-57	252	12	sk	sk	PROPN
bptjm-57	252	13	.	.	PROPN
bptjm-57	252	14	ccast	ccast	NOUN
bptjm-57	252	15	:	:	PUNCT
bptjm-57	252	16	amodel	amodel	PROPN
bptjm-57	252	17	-	-	PUNCT
bptjm-57	252	18	based	base	VERB
bptjm-57	252	19	gating	gating	NOUN
bptjm-57	252	20	strategy	strategy	NOUN
bptjm-57	252	21	to	to	PART
bptjm-57	252	22	isolate	isolate	VERB
bptjm-57	252	23	homogeneous	homogeneous	ADJ
bptjm-57	252	24	subpopulations	subpopulation	NOUN
bptjm-57	252	25	in	in	ADP
bptjm-57	252	26	a	a	DET
bptjm-57	252	27	heterogeneous	heterogeneous	ADJ
bptjm-57	252	28	population	population	NOUN
bptjm-57	252	29	of	of	ADP
bptjm-57	252	30	single	single	ADJ
bptjm-57	252	31	cells	cell	NOUN
bptjm-57	252	32	.	.	PUNCT
bptjm-57	253	1	plos	plos	PROPN
bptjm-57	253	2	computational	computational	ADJ
bptjm-57	253	3	biology	biology	NOUN
bptjm-57	253	4	.	.	PUNCT
bptjm-57	254	1	2014;10(7):e1003664	2014;10(7):e1003664	X
bptjm-57	254	2	.	.	NOUN
bptjm-57	254	3	doi	doi	NOUN
bptjm-57	254	4	:	:	PUNCT
bptjm-57	254	5	10.1371	10.1371	NUM
bptjm-57	254	6	/	/	SYM
bptjm-57	254	7	journal.pcbi.1003664	journal.pcbi.1003664	PROPN
bptjm-57	254	8	.	.	PUNCT
bptjm-57	255	1	7	7	X
bptjm-57	255	2	.	.	X
bptjm-57	255	3	ramón	ramón	PROPN
bptjm-57	255	4	y	y	PROPN
bptjm-57	255	5	cajal	cajal	PROPN
bptjm-57	255	6	s	s	PROPN
bptjm-57	255	7	,	,	PUNCT
bptjm-57	255	8	sesé	sesé	PROPN
bptjm-57	255	9	m	m	PROPN
bptjm-57	255	10	,	,	PUNCT
bptjm-57	255	11	capdevila	capdevila	PROPN
bptjm-57	255	12	c	c	NOUN
bptjm-57	255	13	,	,	PUNCT
bptjm-57	255	14	et	et	PROPN
bptjm-57	255	15	al	al	PROPN
bptjm-57	255	16	.	.	PUNCT
bptjm-57	256	1	clinical	clinical	ADJ
bptjm-57	256	2	implications	implication	NOUN
bptjm-57	256	3	of	of	ADP
bptjm-57	256	4	intratumor	intratumor	PROPN
bptjm-57	256	5	heterogeneity	heterogeneity	NOUN
bptjm-57	256	6	:	:	PUNCT
bptjm-57	256	7	challenges	challenge	NOUN
bptjm-57	256	8	and	and	CCONJ
bptjm-57	256	9	opportunities	opportunity	NOUN
bptjm-57	256	10	.	.	PUNCT
bptjm-57	257	1	j	j	PROPN
bptjm-57	257	2	molmed	molme	VERB
bptjm-57	257	3	(	(	PUNCT
bptjm-57	257	4	berl	berl	PROPN
bptjm-57	257	5	)	)	PUNCT
bptjm-57	257	6	.	.	PUNCT
bptjm-57	258	1	2020;98(2):161	2020;98(2):161	NUM
bptjm-57	258	2	-	-	SYM
bptjm-57	258	3	177	177	NUM
bptjm-57	258	4	.	.	PUNCT
bptjm-57	259	1	doi:10.1007	doi:10.1007	VERB
bptjm-57	259	2	/	/	SYM
bptjm-57	259	3	s00109	s00109	VERB
bptjm-57	259	4	-	-	PUNCT
bptjm-57	259	5	020	020	NUM
bptjm-57	259	6	-	-	PUNCT
bptjm-57	259	7	01874	01874	NUM
bptjm-57	259	8	-	-	PUNCT
bptjm-57	259	9	2	2	NUM
bptjm-57	259	10	.	.	NOUN
bptjm-57	259	11	8	8	NUM
bptjm-57	259	12	.	.	PUNCT
bptjm-57	260	1	alizadeh	alizadeh	PROPN
bptjm-57	260	2	aa	aa	PROPN
bptjm-57	260	3	,	,	PUNCT
bptjm-57	260	4	aranda	aranda	NOUN
bptjm-57	260	5	v	v	NOUN
bptjm-57	260	6	,	,	PUNCT
bptjm-57	260	7	bardelli	bardelli	VERB
bptjm-57	260	8	a	a	PRON
bptjm-57	260	9	,	,	PUNCT
bptjm-57	260	10	et	et	PROPN
bptjm-57	260	11	al	al	PROPN
bptjm-57	260	12	.	.	PROPN
bptjm-57	261	1	toward	toward	ADP
bptjm-57	261	2	understanding	understanding	NOUN
bptjm-57	261	3	and	and	CCONJ
bptjm-57	261	4	exploiting	exploit	VERB
bptjm-57	261	5	tumor	tumor	NOUN
bptjm-57	261	6	heterogeneity	heterogeneity	NOUN
bptjm-57	261	7	.	.	PUNCT
bptjm-57	262	1	natmed	natme	VERB
bptjm-57	262	2	.	.	PUNCT
bptjm-57	263	1	2015;21(8):846	2015;21(8):846	NUM
bptjm-57	263	2	-	-	SYM
bptjm-57	263	3	853	853	NUM
bptjm-57	263	4	.	.	PUNCT
bptjm-57	264	1	doi:10.1038	doi:10.1038	NOUN
bptjm-57	264	2	/	/	SYM
bptjm-57	264	3	nm.3915	nm.3915	PROPN
bptjm-57	264	4	.	.	PROPN
bptjm-57	264	5	9	9	NUM
bptjm-57	264	6	.	.	PUNCT
bptjm-57	265	1	jiao	jiao	PROPN
bptjm-57	265	2	y	y	PROPN
bptjm-57	265	3	,	,	PUNCT
bptjm-57	265	4	li	li	PROPN
bptjm-57	265	5	s	s	PROPN
bptjm-57	265	6	,	,	PUNCT
bptjm-57	265	7	wang	wang	PROPN
bptjm-57	265	8	x	x	PROPN
bptjm-57	265	9	,	,	PUNCT
bptjm-57	265	10	et	et	PROPN
bptjm-57	265	11	al	al	PROPN
bptjm-57	265	12	.	.	PUNCT
bptjm-57	266	1	a	a	DET
bptjm-57	266	2	genomic	genomic	NOUN
bptjm-57	266	3	instability	instability	NOUN
bptjm-57	266	4	-	-	PUNCT
bptjm-57	266	5	related	relate	VERB
bptjm-57	266	6	lncrnamodel	lncrnamodel	NOUN
bptjm-57	266	7	for	for	ADP
bptjm-57	266	8	predicting	predict	VERB
bptjm-57	266	9	prognosis	prognosis	NOUN
bptjm-57	266	10	and	and	CCONJ
bptjm-57	266	11	immune	immune	ADJ
bptjm-57	266	12	checkpoint	checkpoint	NOUN
bptjm-57	266	13	inhibitor	inhibitor	NOUN
bptjm-57	266	14	e	e	PROPN
bptjm-57	266	15	�	�	PROPN
bptjm-57	266	16	cacy	cacy	NOUN
bptjm-57	266	17	in	in	ADP
bptjm-57	266	18	breast	breast	NOUN
bptjm-57	266	19	cancer	cancer	NOUN
bptjm-57	266	20	.	.	PUNCT
bptjm-57	267	1	front	front	ADJ
bptjm-57	267	2	immunol	immunol	NOUN
bptjm-57	267	3	.	.	PUNCT
bptjm-57	268	1	2022;13:929846	2022;13:929846	NUM
bptjm-57	268	2	.	.	PUNCT
bptjm-57	268	3	doi:10.3389/	doi:10.3389/	PROPN
bptjm-57	268	4	�	�	NOUN
bptjm-57	268	5	mmu.2022.929846	mmu.2022.929846	NOUN
bptjm-57	268	6	.	.	PROPN
bptjm-57	268	7	10	10	NUM
bptjm-57	268	8	.	.	PUNCT
bptjm-57	269	1	el	el	PROPN
bptjm-57	269	2	-	-	PUNCT
bptjm-57	269	3	sayes	saye	NOUN
bptjm-57	269	4	n	n	CCONJ
bptjm-57	269	5	,	,	PUNCT
bptjm-57	269	6	vito	vito	PROPN
bptjm-57	269	7	a	a	PRON
bptjm-57	270	1	,	,	PUNCT
bptjm-57	270	2	mossman	mossman	PROPN
bptjm-57	270	3	k.	k.	PROPN
bptjm-57	270	4	tumor	tumor	PROPN
bptjm-57	270	5	heterogeneity	heterogeneity	PROPN
bptjm-57	270	6	:	:	PUNCT
bptjm-57	270	7	a	a	DET
bptjm-57	270	8	great	great	ADJ
bptjm-57	270	9	barrier	barrier	NOUN
bptjm-57	270	10	in	in	ADP
bptjm-57	270	11	the	the	DET
bptjm-57	270	12	age	age	NOUN
bptjm-57	270	13	of	of	ADP
bptjm-57	270	14	cancer	cancer	NOUN
bptjm-57	270	15	immunotherapy	immunotherapy	NOUN
bptjm-57	270	16	.	.	PUNCT
bptjm-57	271	1	cancers	cancer	NOUN
bptjm-57	271	2	(	(	PUNCT
bptjm-57	271	3	basel	basel	PROPN
bptjm-57	271	4	)	)	PUNCT
bptjm-57	271	5	.	.	PUNCT
bptjm-57	272	1	2021;13(4):806	2021;13(4):806	PROPN
bptjm-57	272	2	.	.	PUNCT
bptjm-57	273	1	doi:10.3390	doi:10.3390	NOUN
bptjm-57	273	2	/	/	SYM
bptjm-57	273	3	cancers13040806	cancers13040806	PROPN
bptjm-57	273	4	.	.	PUNCT
bptjm-57	274	1	11	11	NUM
bptjm-57	274	2	.	.	PUNCT
bptjm-57	274	3	clonal	clonal	ADJ
bptjm-57	274	4	evolution	evolution	NOUN
bptjm-57	274	5	in	in	ADP
bptjm-57	274	6	cancer	cancer	NOUN
bptjm-57	274	7	|	|	CCONJ
bptjm-57	274	8	mission	mission	NOUN
bptjm-57	274	9	bio	bio	PROPN
bptjm-57	274	10	.	.	PROPN
bptjm-57	274	11	accessed	access	VERB
bptjm-57	274	12	august	august	PROPN
bptjm-57	274	13	11	11	NUM
bptjm-57	274	14	,	,	PUNCT
bptjm-57	274	15	2023	2023	NUM
bptjm-57	274	16	.	.	PUNCT
bptjm-57	275	1	https://missionbio.com/resources/learning-cen	https://missionbio.com/resources/learning-cen	PROPN
bptjm-57	275	2	ter	ter	NOUN
bptjm-57	275	3	/	/	SYM
bptjm-57	275	4	clonal	clonal	ADJ
bptjm-57	275	5	-	-	PUNCT
bptjm-57	275	6	evolution	evolution	NOUN
bptjm-57	275	7	-	-	PUNCT
bptjm-57	275	8	in	in	ADP
bptjm-57	275	9	-	-	PUNCT
bptjm-57	275	10	cancer/.	cancer/.	NOUN
bptjm-57	275	11	12	12	NUM
bptjm-57	275	12	.	.	PUNCT
bptjm-57	276	1	greaves	greave	NOUN
bptjm-57	276	2	m	m	PROPN
bptjm-57	276	3	,	,	PUNCT
bptjm-57	276	4	maley	maley	PROPN
bptjm-57	276	5	cc	cc	PROPN
bptjm-57	276	6	.	.	PROPN
bptjm-57	276	7	clonal	clonal	ADJ
bptjm-57	276	8	evolution	evolution	NOUN
bptjm-57	276	9	in	in	ADP
bptjm-57	276	10	cancer.nature	cancer.nature	NOUN
bptjm-57	276	11	.	.	PUNCT
bptjm-57	277	1	2012;481(7381):306	2012;481(7381):306	NUM
bptjm-57	277	2	-	-	SYM
bptjm-57	277	3	313	313	NUM
bptjm-57	277	4	.	.	PUNCT
bptjm-57	277	5	doi	doi	NOUN
bptjm-57	277	6	:	:	PUNCT
bptjm-57	277	7	10.1038	10.1038	NUM
bptjm-57	277	8	/	/	SYM
bptjm-57	277	9	nature10762	nature10762	NOUN
bptjm-57	277	10	.	.	PUNCT
bptjm-57	278	1	13	13	NUM
bptjm-57	278	2	.	.	PUNCT
bptjm-57	278	3	anderson	anderson	PROPN
bptjm-57	278	4	nm	nm	PROPN
bptjm-57	278	5	,	,	PUNCT
bptjm-57	278	6	simonmc	simonmc	NOUN
bptjm-57	278	7	.	.	PUNCT
bptjm-57	279	1	the	the	DET
bptjm-57	279	2	tumor	tumor	NOUN
bptjm-57	279	3	microenvironment	microenvironment	NOUN
bptjm-57	279	4	.	.	PUNCT
bptjm-57	280	1	curr	curr	PROPN
bptjm-57	280	2	biol	biol	PROPN
bptjm-57	280	3	.	.	PUNCT
bptjm-57	281	1	2020;30(16):r921	2020;30(16):r921	X
bptjm-57	281	2	-	-	PUNCT
bptjm-57	281	3	r925	r925	PROPN
bptjm-57	281	4	.	.	PUNCT
bptjm-57	281	5	doi:10.1016	doi:10.1016	PROPN
bptjm-57	281	6	/	/	SYM
bptjm-57	281	7	j.cub.2020.06.081	j.cub.2020.06.081	PROPN
bptjm-57	281	8	.	.	PUNCT
bptjm-57	282	1	14	14	NUM
bptjm-57	282	2	.	.	PUNCT
bptjm-57	283	1	jiang	jiang	PROPN
bptjm-57	283	2	x	x	PROPN
bptjm-57	283	3	,	,	PUNCT
bptjm-57	283	4	wang	wang	PROPN
bptjm-57	283	5	j	j	PROPN
bptjm-57	283	6	,	,	PUNCT
bptjm-57	283	7	deng	deng	PROPN
bptjm-57	283	8	x	x	PROPN
bptjm-57	283	9	,	,	PUNCT
bptjm-57	283	10	et	et	PROPN
bptjm-57	283	11	al	al	PROPN
bptjm-57	283	12	.	.	PUNCT
bptjm-57	284	1	the	the	DET
bptjm-57	284	2	role	role	NOUN
bptjm-57	284	3	of	of	ADP
bptjm-57	284	4	microenvironment	microenvironment	NOUN
bptjm-57	284	5	in	in	ADP
bptjm-57	284	6	tumor	tumor	NOUN
bptjm-57	284	7	angiogenesis	angiogenesis	PROPN
bptjm-57	284	8	.	.	PUNCT
bptjm-57	285	1	journal	journal	NOUN
bptjm-57	285	2	of	of	ADP
bptjm-57	285	3	experimental	experimental	PROPN
bptjm-57	285	4	&	&	CCONJ
bptjm-57	285	5	clinical	clinical	ADJ
bptjm-57	285	6	cancer	cancer	NOUN
bptjm-57	285	7	research	research	NOUN
bptjm-57	285	8	.	.	PUNCT
bptjm-57	286	1	2020;39(1):204	2020;39(1):204	NUM
bptjm-57	286	2	.	.	PUNCT
bptjm-57	287	1	doi:10.1186	doi:10.1186	PROPN
bptjm-57	287	2	/	/	SYM
bptjm-57	287	3	s13046	s13046	PROPN
bptjm-57	287	4	-	-	PUNCT
bptjm-57	287	5	020	020	NUM
bptjm-57	287	6	-	-	PUNCT
bptjm-57	287	7	01709	01709	NUM
bptjm-57	287	8	-	-	PUNCT
bptjm-57	287	9	5	5	NUM
bptjm-57	287	10	.	.	NOUN
bptjm-57	287	11	15	15	NUM
bptjm-57	287	12	.	.	PUNCT
bptjm-57	288	1	gupta	gupta	PROPN
bptjm-57	288	2	pb	pb	ADP
bptjm-57	288	3	,	,	PUNCT
bptjm-57	288	4	pastushenko	pastushenko	PROPN
bptjm-57	288	5	i	i	PRON
bptjm-57	288	6	,	,	PUNCT
bptjm-57	288	7	skibinski	skibinski	VERB
bptjm-57	288	8	a	a	DET
bptjm-57	288	9	,	,	PUNCT
bptjm-57	288	10	blanpain	blanpain	NOUN
bptjm-57	288	11	c	c	NOUN
bptjm-57	288	12	,	,	PUNCT
bptjm-57	288	13	kuperwasser	kuperwasser	PROPN
bptjm-57	288	14	c.	c.	PROPN
bptjm-57	288	15	phenotypic	phenotypic	PROPN
bptjm-57	288	16	plasticity	plasticity	NOUN
bptjm-57	288	17	berkeley	berkeley	PROPN
bptjm-57	288	18	pharma	pharma	PROPN
bptjm-57	288	19	tech	tech	NOUN
bptjm-57	288	20	journal	journal	NOUN
bptjm-57	288	21	of	of	ADP
bptjm-57	288	22	medicine	medicine	NOUN
bptjm-57	288	23	|	|	ADV
bptjm-57	288	24	107	107	NUM
bptjm-57	288	25	https://doi.org/10.1371/journal.pcbi.1003664	https://doi.org/10.1371/journal.pcbi.1003664	NOUN
bptjm-57	288	26	https://doi.org/10.1371/journal.pcbi.1003664	https://doi.org/10.1371/journal.pcbi.1003664	NOUN
bptjm-57	288	27	https://doi.org/10.1038/nature10762	https://doi.org/10.1038/nature10762	NOUN
bptjm-57	288	28	https://doi.org/10.1038/nature10762	https://doi.org/10.1038/nature10762	NOUN
bptjm-57	288	29	as	as	ADP
bptjm-57	288	30	a	a	DET
bptjm-57	288	31	driver	driver	NOUN
bptjm-57	288	32	of	of	ADP
bptjm-57	288	33	cancer	cancer	NOUN
bptjm-57	288	34	formation	formation	NOUN
bptjm-57	288	35	,	,	PUNCT
bptjm-57	288	36	progression	progression	NOUN
bptjm-57	288	37	and	and	CCONJ
bptjm-57	288	38	resistance	resistance	NOUN
bptjm-57	288	39	to	to	ADP
bptjm-57	288	40	therapy	therapy	NOUN
bptjm-57	288	41	.	.	PUNCT
bptjm-57	289	1	cell	cell	NOUN
bptjm-57	289	2	stem	stem	NOUN
bptjm-57	289	3	cell	cell	NOUN
bptjm-57	289	4	.	.	PUNCT
bptjm-57	290	1	2019;24(1):65	2019;24(1):65	NUM
bptjm-57	290	2	-	-	SYM
bptjm-57	290	3	78	78	NUM
bptjm-57	290	4	.	.	PUNCT
bptjm-57	291	1	doi:10.1016	doi:10.1016	PROPN
bptjm-57	291	2	/	/	SYM
bptjm-57	291	3	j.stem.2018.11.011	j.stem.2018.11.011	PROPN
bptjm-57	291	4	.	.	PROPN
bptjm-57	292	1	16	16	NUM
bptjm-57	292	2	.	.	PUNCT
bptjm-57	292	3	wum	wum	PROPN
bptjm-57	292	4	,	,	PUNCT
bptjm-57	292	5	zhang	zhang	PROPN
bptjm-57	292	6	x	x	PROPN
bptjm-57	292	7	,	,	PUNCT
bptjm-57	292	8	zhangw	zhangw	PROPN
bptjm-57	292	9	,	,	PUNCT
bptjm-57	292	10	et	et	PROPN
bptjm-57	292	11	al	al	PROPN
bptjm-57	292	12	.	.	PUNCT
bptjm-57	292	13	cancer	cancer	NOUN
bptjm-57	292	14	stem	stem	NOUN
bptjm-57	292	15	cell	cell	NOUN
bptjm-57	292	16	regulated	regulate	VERB
bptjm-57	292	17	phenotypic	phenotypic	ADJ
bptjm-57	292	18	plasticity	plasticity	NOUN
bptjm-57	292	19	protects	protect	VERB
bptjm-57	292	20	metastasized	metastasize	VERB
bptjm-57	292	21	cancer	cancer	NOUN
bptjm-57	292	22	cells	cell	NOUN
bptjm-57	292	23	from	from	ADP
bptjm-57	292	24	ferroptosis.nat	ferroptosis.nat	NOUN
bptjm-57	292	25	commun	commun	NOUN
bptjm-57	292	26	.	.	PUNCT
bptjm-57	293	1	2022;13:1371	2022;13:1371	X
bptjm-57	293	2	.	.	PUNCT
bptjm-57	293	3	doi:10.1038	doi:10.1038	PROPN
bptjm-57	293	4	/	/	SYM
bptjm-57	293	5	s41467	s41467	NOUN
bptjm-57	293	6	-	-	PUNCT
bptjm-57	293	7	022	022	NUM
bptjm-57	293	8	-	-	PUNCT
bptjm-57	293	9	29018	29018	NUM
bptjm-57	293	10	-	-	SYM
bptjm-57	293	11	9	9	NUM
bptjm-57	293	12	.	.	NOUN
bptjm-57	293	13	17	17	NUM
bptjm-57	293	14	.	.	PUNCT
bptjm-57	293	15	vogelstein	vogelstein	PROPN
bptjm-57	293	16	b	b	PROPN
bptjm-57	293	17	,	,	PUNCT
bptjm-57	293	18	papadopoulos	papadopoulos	PROPN
bptjm-57	293	19	n	n	CCONJ
bptjm-57	293	20	,	,	PUNCT
bptjm-57	293	21	velculescu	velculescu	PROPN
bptjm-57	293	22	ve	ve	PROPN
bptjm-57	293	23	,	,	PUNCT
bptjm-57	293	24	zhou	zhou	PROPN
bptjm-57	293	25	s	s	PROPN
bptjm-57	293	26	,	,	PUNCT
bptjm-57	293	27	diaz	diaz	PROPN
bptjm-57	293	28	la	la	PROPN
bptjm-57	293	29	jr	jr	PROPN
bptjm-57	293	30	,	,	PUNCT
bptjm-57	293	31	kinzler	kinzler	NOUN
bptjm-57	293	32	kw	kw	PROPN
bptjm-57	293	33	.	.	PUNCT
bptjm-57	293	34	cancer	cancer	NOUN
bptjm-57	293	35	genome	genome	NOUN
bptjm-57	293	36	landscapes	landscape	NOUN
bptjm-57	293	37	.	.	PUNCT
bptjm-57	294	1	science	science	NOUN
bptjm-57	294	2	.	.	PUNCT
bptjm-57	295	1	2013;339(6127):1546	2013;339(6127):1546	NUM
bptjm-57	295	2	-	-	SYM
bptjm-57	295	3	1558	1558	NUM
bptjm-57	295	4	.	.	PUNCT
bptjm-57	296	1	doi:10.1126	doi:10.1126	PROPN
bptjm-57	296	2	/	/	SYM
bptjm-57	296	3	science.1235122	science.1235122	PROPN
bptjm-57	296	4	.	.	PROPN
bptjm-57	296	5	18	18	NUM
bptjm-57	296	6	.	.	PUNCT
bptjm-57	297	1	feng	feng	PROPN
bptjm-57	297	2	y	y	PROPN
bptjm-57	297	3	,	,	PUNCT
bptjm-57	297	4	spezia	spezia	VERB
bptjm-57	297	5	m	m	PROPN
bptjm-57	297	6	,	,	PUNCT
bptjm-57	297	7	huang	huang	PROPN
bptjm-57	297	8	s	s	PROPN
bptjm-57	297	9	,	,	PUNCT
bptjm-57	297	10	et	et	PROPN
bptjm-57	297	11	al	al	PROPN
bptjm-57	297	12	.	.	PUNCT
bptjm-57	297	13	breast	breast	NOUN
bptjm-57	297	14	cancer	cancer	NOUN
bptjm-57	297	15	development	development	NOUN
bptjm-57	297	16	and	and	CCONJ
bptjm-57	297	17	progression	progression	NOUN
bptjm-57	297	18	:	:	PUNCT
bptjm-57	297	19	risk	risk	NOUN
bptjm-57	297	20	factors	factor	NOUN
bptjm-57	297	21	,	,	PUNCT
bptjm-57	297	22	cancer	cancer	NOUN
bptjm-57	297	23	stem	stem	NOUN
bptjm-57	297	24	cells	cell	NOUN
bptjm-57	297	25	,	,	PUNCT
bptjm-57	297	26	signaling	signal	VERB
bptjm-57	297	27	pathways	pathway	NOUN
bptjm-57	297	28	,	,	PUNCT
bptjm-57	297	29	genomics	genomic	NOUN
bptjm-57	297	30	,	,	PUNCT
bptjm-57	297	31	and	and	CCONJ
bptjm-57	297	32	molecular	molecular	ADJ
bptjm-57	297	33	pathogenesis	pathogenesis	NOUN
bptjm-57	297	34	.	.	PUNCT
bptjm-57	298	1	genes	gene	NOUN
bptjm-57	298	2	dis	dis	PROPN
bptjm-57	298	3	.	.	PUNCT
bptjm-57	299	1	2018;5(2):77	2018;5(2):77	NUM
bptjm-57	299	2	-	-	SYM
bptjm-57	299	3	106	106	NUM
bptjm-57	299	4	.	.	PUNCT
bptjm-57	299	5	doi:10.1016	doi:10.1016	PROPN
bptjm-57	299	6	/	/	SYM
bptjm-57	299	7	j.gendis.2018.05.001	j.gendis.2018.05.001	PROPN
bptjm-57	299	8	.	.	PROPN
bptjm-57	300	1	19	19	NUM
bptjm-57	300	2	.	.	PUNCT
bptjm-57	301	1	tarigopula	tarigopula	PROPN
bptjm-57	301	2	a	a	PRON
bptjm-57	301	3	,	,	PUNCT
bptjm-57	301	4	ramasubban	ramasubban	NOUN
bptjm-57	301	5	g	g	NOUN
bptjm-57	301	6	,	,	PUNCT
bptjm-57	301	7	chandrashekar	chandrashekar	VERB
bptjm-57	301	8	v	v	NOUN
bptjm-57	301	9	,	,	PUNCT
bptjm-57	301	10	govindasami	govindasami	NOUN
bptjm-57	301	11	p	p	NOUN
bptjm-57	301	12	,	,	PUNCT
bptjm-57	301	13	chandran	chandran	PROPN
bptjm-57	301	14	c.	c.	PROPN
bptjm-57	301	15	egfrmutations	egfrmutation	NOUN
bptjm-57	301	16	and	and	CCONJ
bptjm-57	301	17	ros1	ros1	PROPN
bptjm-57	301	18	and	and	CCONJ
bptjm-57	301	19	alk	alk	VERB
bptjm-57	301	20	rearrangements	rearrangement	NOUN
bptjm-57	301	21	in	in	ADP
bptjm-57	301	22	a	a	DET
bptjm-57	301	23	large	large	ADJ
bptjm-57	301	24	series	series	NOUN
bptjm-57	301	25	of	of	ADP
bptjm-57	301	26	non	non	ADJ
bptjm-57	301	27	-	-	ADJ
bptjm-57	301	28	small	small	ADJ
bptjm-57	301	29	cell	cell	NOUN
bptjm-57	301	30	lung	lung	NOUN
bptjm-57	301	31	cancer	cancer	NOUN
bptjm-57	301	32	in	in	ADP
bptjm-57	301	33	south	south	PROPN
bptjm-57	301	34	india	india	PROPN
bptjm-57	301	35	.	.	PUNCT
bptjm-57	302	1	cancer	cancer	PROPN
bptjm-57	302	2	rep	rep	PROPN
bptjm-57	302	3	(	(	PUNCT
bptjm-57	302	4	hoboken	hoboken	PROPN
bptjm-57	302	5	)	)	PUNCT
bptjm-57	302	6	.	.	PUNCT
bptjm-57	303	1	2020;3(6):e1288	2020;3(6):e1288	X
bptjm-57	303	2	.	.	PUNCT
bptjm-57	304	1	doi:10.1002	doi:10.1002	NOUN
bptjm-57	304	2	/	/	SYM
bptjm-57	304	3	cnr2.1288	cnr2.1288	PROPN
bptjm-57	304	4	.	.	PUNCT
bptjm-57	305	1	20	20	NUM
bptjm-57	305	2	.	.	PUNCT
bptjm-57	306	1	boch	boch	PROPN
bptjm-57	306	2	c	c	PROPN
bptjm-57	306	3	,	,	PUNCT
bptjm-57	306	4	kollmeier	kollmeier	PROPN
bptjm-57	306	5	j	j	PROPN
bptjm-57	306	6	,	,	PUNCT
bptjm-57	306	7	roth	roth	PROPN
bptjm-57	306	8	a	a	PRON
bptjm-57	306	9	,	,	PUNCT
bptjm-57	306	10	et	et	PROPN
bptjm-57	306	11	al	al	PROPN
bptjm-57	306	12	.	.	PUNCT
bptjm-57	307	1	the	the	DET
bptjm-57	307	2	frequency	frequency	NOUN
bptjm-57	307	3	of	of	ADP
bptjm-57	307	4	egfr	egfr	NOUN
bptjm-57	307	5	and	and	CCONJ
bptjm-57	307	6	krasmutations	krasmutation	NOUN
bptjm-57	307	7	in	in	ADP
bptjm-57	307	8	non	non	ADJ
bptjm-57	307	9	-	-	ADJ
bptjm-57	307	10	small	small	ADJ
bptjm-57	307	11	cell	cell	NOUN
bptjm-57	307	12	lung	lung	NOUN
bptjm-57	307	13	cancer	cancer	NOUN
bptjm-57	307	14	(	(	PUNCT
bptjm-57	307	15	nsclc	nsclc	NOUN
bptjm-57	307	16	):	):	PUNCT
bptjm-57	307	17	routine	routine	ADJ
bptjm-57	307	18	screening	screening	NOUN
bptjm-57	307	19	data	datum	NOUN
bptjm-57	307	20	for	for	ADP
bptjm-57	307	21	central	central	ADJ
bptjm-57	307	22	europe	europe	PROPN
bptjm-57	307	23	from	from	ADP
bptjm-57	307	24	a	a	DET
bptjm-57	307	25	cohort	cohort	NOUN
bptjm-57	307	26	study	study	NOUN
bptjm-57	307	27	.	.	PUNCT
bptjm-57	308	1	bmj	bmj	PROPN
bptjm-57	308	2	open	open	ADJ
bptjm-57	308	3	.	.	PUNCT
bptjm-57	309	1	2013;3(4):e002560	2013;3(4):e002560	X
bptjm-57	309	2	.	.	PUNCT
bptjm-57	310	1	doi:10.1136	doi:10.1136	NOUN
bptjm-57	310	2	/	/	SYM
bptjm-57	310	3	bmjopen-2013	bmjopen-2013	NOUN
bptjm-57	310	4	-	-	PUNCT
bptjm-57	310	5	002560	002560	NUM
bptjm-57	310	6	.	.	PUNCT
bptjm-57	311	1	21	21	NUM
bptjm-57	311	2	.	.	PUNCT
bptjm-57	312	1	liuw	liuw	PROPN
bptjm-57	312	2	,	,	PUNCT
bptjm-57	312	3	wang	wang	PROPN
bptjm-57	312	4	s	s	PROPN
bptjm-57	312	5	,	,	PUNCT
bptjm-57	312	6	lin	lin	PROPN
bptjm-57	312	7	b	b	PROPN
bptjm-57	312	8	,	,	PUNCT
bptjm-57	312	9	zhangw	zhangw	PROPN
bptjm-57	312	10	,	,	PUNCT
bptjm-57	312	11	ji	ji	PROPN
bptjm-57	312	12	g.	g.	PROPN
bptjm-57	312	13	applications	application	NOUN
bptjm-57	312	14	of	of	ADP
bptjm-57	312	15	crispr	crispr	NOUN
bptjm-57	312	16	/	/	SYM
bptjm-57	312	17	cas9	cas9	NOUN
bptjm-57	312	18	in	in	ADP
bptjm-57	312	19	the	the	DET
bptjm-57	312	20	research	research	NOUN
bptjm-57	312	21	of	of	ADP
bptjm-57	312	22	malignant	malignant	ADJ
bptjm-57	312	23	musculoskeletal	musculoskeletal	ADJ
bptjm-57	312	24	tumors	tumor	NOUN
bptjm-57	312	25	.	.	PUNCT
bptjm-57	313	1	bmc	bmc	PROPN
bptjm-57	313	2	musculoskelet	musculoskelet	NOUN
bptjm-57	313	3	disord	disord	NOUN
bptjm-57	313	4	.	.	PUNCT
bptjm-57	314	1	2021;22(1):149	2021;22(1):149	NOUN
bptjm-57	314	2	.	.	PUNCT
bptjm-57	315	1	doi:10.1186	doi:10.1186	PROPN
bptjm-57	315	2	/	/	SYM
bptjm-57	315	3	s12891	s12891	NUM
bptjm-57	315	4	-	-	PUNCT
bptjm-57	315	5	021	021	NUM
bptjm-57	315	6	-	-	PUNCT
bptjm-57	315	7	04020	04020	NUM
bptjm-57	315	8	-	-	PUNCT
bptjm-57	315	9	2	2	NUM
bptjm-57	315	10	.	.	NOUN
bptjm-57	315	11	22	22	NUM
bptjm-57	315	12	.	.	PUNCT
bptjm-57	316	1	kumar	kumar	PROPN
bptjm-57	316	2	b	b	PROPN
bptjm-57	316	3	,	,	PUNCT
bptjm-57	316	4	prasadm	prasadm	PROPN
bptjm-57	316	5	,	,	PUNCT
bptjm-57	316	6	bhat	bhat	PROPN
bptjm-57	316	7	-	-	PUNCT
bptjm-57	316	8	nakshatri	nakshatri	PROPN
bptjm-57	316	9	p	p	NOUN
bptjm-57	316	10	,	,	PUNCT
bptjm-57	316	11	et	et	PROPN
bptjm-57	316	12	al	al	PROPN
bptjm-57	316	13	.	.	PROPN
bptjm-57	316	14	normal	normal	ADJ
bptjm-57	316	15	breast	breast	NOUN
bptjm-57	316	16	-	-	PUNCT
bptjm-57	316	17	derived	derive	VERB
bptjm-57	316	18	epithelial	epithelial	ADJ
bptjm-57	316	19	cells	cell	NOUN
bptjm-57	316	20	with	with	ADP
bptjm-57	316	21	luminal	luminal	ADJ
bptjm-57	316	22	and	and	CCONJ
bptjm-57	316	23	intrinsic	intrinsic	ADJ
bptjm-57	316	24	subtype	subtype	NOUN
bptjm-57	316	25	-	-	PUNCT
bptjm-57	316	26	enriched	enrich	VERB
bptjm-57	316	27	gene	gene	NOUN
bptjm-57	316	28	expression	expression	NOUN
bptjm-57	316	29	document	document	NOUN
bptjm-57	316	30	interindividual	interindividual	PROPN
bptjm-57	316	31	di	di	PROPN
bptjm-57	316	32	�	�	PROPN
bptjm-57	316	33	erences	erence	NOUN
bptjm-57	316	34	in	in	ADP
bptjm-57	316	35	their	their	PRON
bptjm-57	316	36	di	di	NOUN
bptjm-57	316	37	�	�	PROPN
bptjm-57	316	38	erentiation	erentiation	NOUN
bptjm-57	316	39	cascade	cascade	NOUN
bptjm-57	316	40	.	.	PUNCT
bptjm-57	317	1	cancer	cancer	NOUN
bptjm-57	317	2	res	re	NOUN
bptjm-57	317	3	.	.	PUNCT
bptjm-57	318	1	2018;78(17):5107	2018;78(17):5107	X
bptjm-57	318	2	-	-	PUNCT
bptjm-57	318	3	5123	5123	NUM
bptjm-57	318	4	.	.	PUNCT
bptjm-57	319	1	doi:10.1158/0008	doi:10.1158/0008	NOUN
bptjm-57	319	2	-	-	PUNCT
bptjm-57	319	3	5472.can-18	5472.can-18	NOUN
bptjm-57	319	4	-	-	PUNCT
bptjm-57	319	5	0509	0509	NUM
bptjm-57	319	6	.	.	PUNCT
bptjm-57	320	1	23	23	NUM
bptjm-57	320	2	.	.	PUNCT
bptjm-57	321	1	wahler	wahler	PROPN
bptjm-57	321	2	j	j	PROPN
bptjm-57	321	3	,	,	PUNCT
bptjm-57	321	4	suh	suh	PROPN
bptjm-57	321	5	n.	n.	NOUN
bptjm-57	321	6	targeting	target	VERB
bptjm-57	321	7	her2	her2	PROPN
bptjm-57	321	8	positive	positive	ADJ
bptjm-57	321	9	breast	breast	NOUN
bptjm-57	321	10	cancer	cancer	NOUN
bptjm-57	321	11	with	with	ADP
bptjm-57	321	12	chemopreventive	chemopreventive	ADJ
bptjm-57	321	13	agents	agent	NOUN
bptjm-57	321	14	.	.	PUNCT
bptjm-57	322	1	curr	curr	PROPN
bptjm-57	322	2	pharmacol	pharmacol	PROPN
bptjm-57	322	3	rep	rep	PROPN
bptjm-57	322	4	.	.	PROPN
bptjm-57	322	5	2015;1(5):324	2015;1(5):324	NUM
bptjm-57	322	6	-	-	PUNCT
bptjm-57	322	7	335	335	NUM
bptjm-57	322	8	.	.	PUNCT
bptjm-57	323	1	doi:10.1007	doi:10.1007	VERB
bptjm-57	323	2	/	/	SYM
bptjm-57	323	3	s40495	s40495	NOUN
bptjm-57	323	4	-	-	PUNCT
bptjm-57	323	5	015	015	NUM
bptjm-57	323	6	-	-	PUNCT
bptjm-57	323	7	0040	0040	NUM
bptjm-57	323	8	-	-	PUNCT
bptjm-57	323	9	z.	z.	PROPN
bptjm-57	323	10	24	24	NUM
bptjm-57	323	11	.	.	PUNCT
bptjm-57	324	1	kanazawa	kanazawa	PROPN
bptjm-57	324	2	h	h	PROPN
bptjm-57	324	3	,	,	PUNCT
bptjm-57	324	4	ebina	ebina	PROPN
bptjm-57	324	5	m	m	PROPN
bptjm-57	324	6	,	,	PUNCT
bptjm-57	324	7	ino	ino	NOUN
bptjm-57	324	8	-	-	PUNCT
bptjm-57	324	9	oka	oka	NOUN
bptjm-57	324	10	n	n	NOUN
bptjm-57	324	11	,	,	PUNCT
bptjm-57	324	12	et	et	PROPN
bptjm-57	324	13	al	al	PROPN
bptjm-57	324	14	.	.	PROPN
bptjm-57	324	15	transition	transition	NOUN
bptjm-57	324	16	from	from	ADP
bptjm-57	324	17	squamous	squamous	ADJ
bptjm-57	324	18	cell	cell	NOUN
bptjm-57	324	19	carcinoma	carcinoma	NOUN
bptjm-57	324	20	to	to	ADP
bptjm-57	324	21	adenocarcinoma	adenocarcinoma	NOUN
bptjm-57	324	22	in	in	ADP
bptjm-57	324	23	adenosquamous	adenosquamous	ADJ
bptjm-57	324	24	carcinoma	carcinoma	NOUN
bptjm-57	324	25	of	of	ADP
bptjm-57	324	26	the	the	DET
bptjm-57	324	27	lung	lung	NOUN
bptjm-57	324	28	.	.	PUNCT
bptjm-57	324	29	am	be	AUX
bptjm-57	324	30	j	j	PROPN
bptjm-57	324	31	pathol	pathol	NOUN
bptjm-57	324	32	.	.	PUNCT
bptjm-57	325	1	2000;156(4):1289	2000;156(4):1289	PROPN
bptjm-57	325	2	-	-	SYM
bptjm-57	325	3	1298	1298	NUM
bptjm-57	325	4	.	.	PUNCT
bptjm-57	326	1	doi:10.1016	doi:10.1016	PROPN
bptjm-57	326	2	/	/	SYM
bptjm-57	326	3	s0002	s0002	NOUN
bptjm-57	326	4	-	-	PUNCT
bptjm-57	326	5	9440(10)64999	9440(10)64999	NOUN
bptjm-57	326	6	-	-	PUNCT
bptjm-57	326	7	1	1	NUM
bptjm-57	326	8	.	.	NUM
bptjm-57	326	9	25	25	NUM
bptjm-57	326	10	.	.	PUNCT
bptjm-57	327	1	jauhri	jauhri	PROPN
bptjm-57	327	2	m	m	PROPN
bptjm-57	327	3	,	,	PUNCT
bptjm-57	327	4	bhatnagar	bhatnagar	PROPN
bptjm-57	327	5	a	a	PROPN
bptjm-57	327	6	,	,	PUNCT
bptjm-57	327	7	gupta	gupta	PROPN
bptjm-57	327	8	s	s	PART
bptjm-57	327	9	,	,	PUNCT
bptjm-57	327	10	et	et	PROPN
bptjm-57	327	11	al	al	PROPN
bptjm-57	327	12	.	.	PUNCT
bptjm-57	327	13	prevalence	prevalence	NOUN
bptjm-57	327	14	and	and	CCONJ
bptjm-57	327	15	coexistence	coexistence	NOUN
bptjm-57	327	16	of	of	ADP
bptjm-57	327	17	kras	kras	PROPN
bptjm-57	327	18	,	,	PUNCT
bptjm-57	327	19	braf	braf	NOUN
bptjm-57	327	20	,	,	PUNCT
bptjm-57	327	21	pik3ca	pik3ca	NOUN
bptjm-57	327	22	,	,	PUNCT
bptjm-57	327	23	nras	nras	PROPN
bptjm-57	327	24	,	,	PUNCT
bptjm-57	327	25	tp53	tp53	PROPN
bptjm-57	327	26	,	,	PUNCT
bptjm-57	327	27	and	and	CCONJ
bptjm-57	327	28	apcmutations	apcmutation	NOUN
bptjm-57	327	29	in	in	ADP
bptjm-57	327	30	indian	indian	ADJ
bptjm-57	327	31	colorectal	colorectal	ADJ
bptjm-57	327	32	cancer	cancer	NOUN
bptjm-57	327	33	patients	patient	NOUN
bptjm-57	327	34	:	:	PUNCT
bptjm-57	327	35	next	next	ADJ
bptjm-57	327	36	-	-	PUNCT
bptjm-57	327	37	generation	generation	NOUN
bptjm-57	327	38	sequencing	sequencing	NOUN
bptjm-57	327	39	-	-	PUNCT
bptjm-57	327	40	based	base	VERB
bptjm-57	327	41	cohort	cohort	NOUN
bptjm-57	327	42	study	study	NOUN
bptjm-57	327	43	.	.	PUNCT
bptjm-57	328	1	tumour	tumour	PROPN
bptjm-57	328	2	biol	biol	PROPN
bptjm-57	328	3	.	.	PUNCT
bptjm-57	329	1	2017;39(2):1010428317692265	2017;39(2):1010428317692265	NUM
bptjm-57	329	2	.	.	PUNCT
bptjm-57	329	3	doi:10.1177/1010428317692265	doi:10.1177/1010428317692265	NOUN
bptjm-57	329	4	.	.	PUNCT
bptjm-57	330	1	26	26	NUM
bptjm-57	330	2	.	.	PUNCT
bptjm-57	331	1	krishna	krishna	PROPN
bptjm-57	331	2	s	s	PART
bptjm-57	331	3	,	,	PUNCT
bptjm-57	331	4	lowery	lowery	PROPN
bptjm-57	331	5	fj	fj	PROPN
bptjm-57	331	6	,	,	PUNCT
bptjm-57	331	7	copeland	copeland	PROPN
bptjm-57	331	8	ar	ar	PROPN
bptjm-57	331	9	,	,	PUNCT
bptjm-57	331	10	et	et	PROPN
bptjm-57	331	11	al	al	PROPN
bptjm-57	331	12	.	.	PUNCT
bptjm-57	331	13	stem	stem	PROPN
bptjm-57	331	14	-	-	PUNCT
bptjm-57	331	15	like	like	ADJ
bptjm-57	331	16	cd8	cd8	PROPN
bptjm-57	331	17	t	t	PROPN
bptjm-57	331	18	cells	cell	NOUN
bptjm-57	331	19	mediate	mediate	VERB
bptjm-57	331	20	response	response	NOUN
bptjm-57	331	21	of	of	ADP
bptjm-57	331	22	adoptive	adoptive	ADJ
bptjm-57	331	23	cell	cell	NOUN
bptjm-57	331	24	immunotherapy	immunotherapy	NOUN
bptjm-57	331	25	against	against	ADP
bptjm-57	331	26	human	human	ADJ
bptjm-57	331	27	cancer	cancer	NOUN
bptjm-57	331	28	.	.	PUNCT
bptjm-57	332	1	science	science	NOUN
bptjm-57	332	2	.	.	PUNCT
bptjm-57	333	1	2020;370(6522):1328	2020;370(6522):1328	NUM
bptjm-57	333	2	-	-	SYM
bptjm-57	333	3	1334	1334	NUM
bptjm-57	333	4	.	.	PUNCT
bptjm-57	334	1	doi:10.1126	doi:10.1126	PROPN
bptjm-57	334	2	/	/	SYM
bptjm-57	334	3	science.abb9847	science.abb9847	PROPN
bptjm-57	334	4	.	.	PUNCT
bptjm-57	335	1	27	27	NUM
bptjm-57	335	2	.	.	X
bptjm-57	336	1	rivera	rivera	NOUN
bptjm-57	336	2	-	-	PUNCT
bptjm-57	336	3	calderón	calderón	PROPN
bptjm-57	336	4	lg	lg	NOUN
bptjm-57	336	5	,	,	PUNCT
bptjm-57	336	6	fonseca	fonseca	PROPN
bptjm-57	336	7	-	-	PUNCT
bptjm-57	336	8	alves	alves	PROPN
bptjm-57	336	9	ce	ce	PROPN
bptjm-57	336	10	,	,	PUNCT
bptjm-57	336	11	kobayashi	kobayashi	PROPN
bptjm-57	336	12	pe	pe	PROPN
bptjm-57	336	13	,	,	PUNCT
bptjm-57	336	14	et	et	PROPN
bptjm-57	336	15	al	al	PROPN
bptjm-57	336	16	.	.	PUNCT
bptjm-57	336	17	alterations	alteration	NOUN
bptjm-57	336	18	in	in	ADP
bptjm-57	336	19	pten	pten	NOUN
bptjm-57	336	20	,	,	PUNCT
bptjm-57	336	21	mdm2	mdm2	PROPN
bptjm-57	336	22	,	,	PUNCT
bptjm-57	336	23	tp53	tp53	PROPN
bptjm-57	336	24	and	and	CCONJ
bptjm-57	336	25	ar	ar	NOUN
bptjm-57	336	26	protein	protein	NOUN
bptjm-57	336	27	and	and	CCONJ
bptjm-57	336	28	gene	gene	NOUN
bptjm-57	336	29	expression	expression	NOUN
bptjm-57	336	30	are	be	AUX
bptjm-57	336	31	associated	associate	VERB
bptjm-57	336	32	with	with	ADP
bptjm-57	336	33	canine	canine	NOUN
bptjm-57	336	34	prostate	prostate	NOUN
bptjm-57	336	35	carcinogenesis.res	carcinogenesis.re	NOUN
bptjm-57	336	36	vet	vet	NOUN
bptjm-57	336	37	sci	sci	PROPN
bptjm-57	336	38	.	.	PUNCT
bptjm-57	336	39	2016;106:56	2016;106:56	NUM
bptjm-57	336	40	-	-	SYM
bptjm-57	336	41	61	61	NUM
bptjm-57	336	42	.	.	PUNCT
bptjm-57	337	1	doi:10.1016	doi:10.1016	PROPN
bptjm-57	337	2	/	/	SYM
bptjm-57	337	3	j.rvsc.2016.03.008	j.rvsc.2016.03.008	PROPN
bptjm-57	337	4	.	.	PUNCT
bptjm-57	338	1	berkeley	berkeley	PROPN
bptjm-57	338	2	pharma	pharma	PROPN
bptjm-57	338	3	tech	tech	PROPN
bptjm-57	338	4	journal	journal	NOUN
bptjm-57	338	5	of	of	ADP
bptjm-57	338	6	medicine	medicine	NOUN
bptjm-57	338	7	|	|	ADV
bptjm-57	338	8	108	108	NUM
bptjm-57	338	9	28	28	NUM
bptjm-57	338	10	.	.	PUNCT
bptjm-57	339	1	ellis	ellis	PROPN
bptjm-57	339	2	l	l	PROPN
bptjm-57	339	3	,	,	PUNCT
bptjm-57	339	4	lodam	lodam	ADJ
bptjm-57	339	5	.	.	PUNCT
bptjm-57	340	1	advanced	advanced	ADJ
bptjm-57	340	2	neuroendocrine	neuroendocrine	ADJ
bptjm-57	340	3	prostate	prostate	NOUN
bptjm-57	340	4	tumors	tumor	NOUN
bptjm-57	340	5	regress	regress	NOUN
bptjm-57	340	6	to	to	PART
bptjm-57	340	7	stemness	stemness	NOUN
bptjm-57	340	8	.	.	PUNCT
bptjm-57	341	1	proc	proc	PROPN
bptjm-57	341	2	natl	natl	PROPN
bptjm-57	341	3	acad	acad	PROPN
bptjm-57	341	4	sci	sci	PROPN
bptjm-57	341	5	u	u	PROPN
bptjm-57	341	6	s	s	PART
bptjm-57	341	7	a.	a.	NOUN
bptjm-57	341	8	2015;112(47):14406	2015;112(47):14406	PROPN
bptjm-57	341	9	-	-	SYM
bptjm-57	341	10	14407	14407	NUM
bptjm-57	341	11	.	.	PUNCT
bptjm-57	342	1	doi:10.1073	doi:10.1073	NOUN
bptjm-57	342	2	/	/	SYM
bptjm-57	343	1	pnas.1519151112	pnas.1519151112	PROPN
bptjm-57	343	2	.	.	PROPN
bptjm-57	343	3	29	29	NUM
bptjm-57	343	4	.	.	PUNCT
bptjm-57	344	1	mei	mei	PROPN
bptjm-57	344	2	w	w	PROPN
bptjm-57	344	3	,	,	PUNCT
bptjm-57	344	4	lin	lin	PROPN
bptjm-57	344	5	x	x	PROPN
bptjm-57	344	6	,	,	PUNCT
bptjm-57	344	7	kapoor	kapoor	PROPN
bptjm-57	344	8	a	a	PROPN
bptjm-57	344	9	,	,	PUNCT
bptjm-57	344	10	gu	gu	NOUN
bptjm-57	344	11	y	y	PROPN
bptjm-57	344	12	,	,	PUNCT
bptjm-57	344	13	zhao	zhao	PROPN
bptjm-57	344	14	k	k	PROPN
bptjm-57	344	15	,	,	PUNCT
bptjm-57	344	16	tang	tang	PROPN
bptjm-57	344	17	d.	d.	PROPN
bptjm-57	344	18	the	the	DET
bptjm-57	344	19	contributions	contribution	NOUN
bptjm-57	344	20	of	of	ADP
bptjm-57	344	21	prostate	prostate	NOUN
bptjm-57	344	22	cancer	cancer	NOUN
bptjm-57	344	23	stem	stem	NOUN
bptjm-57	344	24	cells	cell	NOUN
bptjm-57	344	25	in	in	ADP
bptjm-57	344	26	prostate	prostate	NOUN
bptjm-57	344	27	cancer	cancer	NOUN
bptjm-57	344	28	initiation	initiation	NOUN
bptjm-57	344	29	and	and	CCONJ
bptjm-57	344	30	metastasis	metastasis	NOUN
bptjm-57	344	31	.	.	PUNCT
bptjm-57	345	1	cancers	cancer	NOUN
bptjm-57	345	2	(	(	PUNCT
bptjm-57	345	3	basel	basel	PROPN
bptjm-57	345	4	)	)	PUNCT
bptjm-57	345	5	.	.	PUNCT
bptjm-57	346	1	2019;11(4):434	2019;11(4):434	NUM
bptjm-57	346	2	.	.	PUNCT
bptjm-57	347	1	doi:10.3390	doi:10.3390	NOUN
bptjm-57	347	2	/	/	SYM
bptjm-57	347	3	cancers11040434	cancers11040434	PROPN
bptjm-57	347	4	.	.	PUNCT
bptjm-57	348	1	30	30	NUM
bptjm-57	348	2	.	.	PUNCT
bptjm-57	349	1	watanabe	watanabe	PROPN
bptjm-57	349	2	t	t	PROPN
bptjm-57	349	3	,	,	PUNCT
bptjm-57	349	4	yokoo	yokoo	PROPN
bptjm-57	349	5	h	h	PROPN
bptjm-57	349	6	,	,	PUNCT
bptjm-57	349	7	yokoom	yokoom	NOUN
bptjm-57	349	8	,	,	PUNCT
bptjm-57	349	9	yonekawa	yonekawa	PROPN
bptjm-57	349	10	y	y	PROPN
bptjm-57	349	11	,	,	PUNCT
bptjm-57	349	12	kleihues	kleihue	NOUN
bptjm-57	349	13	p	p	NOUN
bptjm-57	349	14	,	,	PUNCT
bptjm-57	349	15	ohgaki	ohgaki	PROPN
bptjm-57	349	16	h.	h.	PROPN
bptjm-57	349	17	concurrent	concurrent	ADJ
bptjm-57	349	18	inactivation	inactivation	NOUN
bptjm-57	349	19	of	of	ADP
bptjm-57	349	20	rb1	rb1	NOUN
bptjm-57	349	21	and	and	CCONJ
bptjm-57	349	22	tp53	tp53	PROPN
bptjm-57	349	23	pathways	pathway	NOUN
bptjm-57	349	24	in	in	ADP
bptjm-57	349	25	anaplastic	anaplastic	ADJ
bptjm-57	349	26	oligodendrogliomas	oligodendroglioma	NOUN
bptjm-57	349	27	.	.	PUNCT
bptjm-57	350	1	j	j	PROPN
bptjm-57	350	2	neuropathol	neuropathol	PROPN
bptjm-57	350	3	exp	exp	PROPN
bptjm-57	350	4	neurol	neurol	NOUN
bptjm-57	350	5	.	.	PUNCT
bptjm-57	351	1	2001;60(12):1181	2001;60(12):1181	NUM
bptjm-57	351	2	-	-	SYM
bptjm-57	351	3	1189	1189	NUM
bptjm-57	351	4	.	.	PUNCT
bptjm-57	352	1	doi:10.1093	doi:10.1093	NOUN
bptjm-57	352	2	/	/	SYM
bptjm-57	352	3	jnen/60.12.1181	jnen/60.12.1181	NOUN
bptjm-57	352	4	.	.	PUNCT
bptjm-57	353	1	31	31	NUM
bptjm-57	353	2	.	.	PUNCT
bptjm-57	354	1	yoshida	yoshida	PROPN
bptjm-57	354	2	h	h	PROPN
bptjm-57	354	3	,	,	PUNCT
bptjm-57	354	4	adachi	adachi	PROPN
bptjm-57	354	5	h	h	PROPN
bptjm-57	354	6	,	,	PUNCT
bptjm-57	354	7	hamada	hamada	PROPN
bptjm-57	354	8	y	y	PROPN
bptjm-57	354	9	,	,	PUNCT
bptjm-57	354	10	et	et	PROPN
bptjm-57	354	11	al	al	PROPN
bptjm-57	354	12	.	.	PROPN
bptjm-57	354	13	osteosarcoma	osteosarcoma	PROPN
bptjm-57	354	14	.	.	PUNCT
bptjm-57	355	1	ultrastructural	ultrastructural	ADJ
bptjm-57	355	2	and	and	CCONJ
bptjm-57	355	3	immunohistochemical	immunohistochemical	ADJ
bptjm-57	355	4	studies	study	NOUN
bptjm-57	355	5	on	on	ADP
bptjm-57	355	6	alkaline	alkaline	NOUN
bptjm-57	355	7	phosphatase	phosphatase	ADJ
bptjm-57	355	8	-	-	PUNCT
bptjm-57	355	9	positive	positive	ADJ
bptjm-57	355	10	tumor	tumor	NOUN
bptjm-57	355	11	cells	cell	NOUN
bptjm-57	355	12	constituting	constitute	VERB
bptjm-57	355	13	a	a	DET
bptjm-57	355	14	variety	variety	NOUN
bptjm-57	355	15	of	of	ADP
bptjm-57	355	16	histologic	histologic	NOUN
bptjm-57	355	17	types.acta	types.acta	PROPN
bptjm-57	355	18	pathol	pathol	NOUN
bptjm-57	355	19	jpn	jpn	PROPN
bptjm-57	355	20	.	.	PUNCT
bptjm-57	356	1	1988;38(3):325	1988;38(3):325	PROPN
bptjm-57	356	2	-	-	PUNCT
bptjm-57	356	3	338	338	NUM
bptjm-57	356	4	.	.	PUNCT
bptjm-57	357	1	doi:10.1111	doi:10.1111	NOUN
bptjm-57	357	2	/	/	SYM
bptjm-57	357	3	j.1440	j.1440	PROPN
bptjm-57	357	4	-	-	NOUN
bptjm-57	357	5	1827.1988.tb02305.x	1827.1988.tb02305.x	NOUN
bptjm-57	357	6	.	.	PUNCT
bptjm-57	358	1	32	32	NUM
bptjm-57	358	2	.	.	PUNCT
bptjm-57	359	1	platz	platz	PROPN
bptjm-57	359	2	a	a	PROPN
bptjm-57	359	3	,	,	PUNCT
bptjm-57	359	4	egyhazi	egyhazi	PROPN
bptjm-57	359	5	s	s	PART
bptjm-57	359	6	,	,	PUNCT
bptjm-57	359	7	ringborg	ringborg	PROPN
bptjm-57	359	8	u	u	PROPN
bptjm-57	359	9	,	,	PUNCT
bptjm-57	359	10	hansson	hansson	PROPN
bptjm-57	359	11	j.	j.	PROPN
bptjm-57	359	12	human	human	PROPN
bptjm-57	359	13	cutaneous	cutaneous	ADJ
bptjm-57	359	14	melanoma	melanoma	NOUN
bptjm-57	359	15	;	;	PUNCT
bptjm-57	359	16	a	a	DET
bptjm-57	359	17	review	review	NOUN
bptjm-57	359	18	of	of	ADP
bptjm-57	359	19	nras	nras	PROPN
bptjm-57	359	20	and	and	CCONJ
bptjm-57	359	21	brafmutation	brafmutation	NOUN
bptjm-57	359	22	frequencies	frequency	NOUN
bptjm-57	359	23	in	in	ADP
bptjm-57	359	24	relation	relation	NOUN
bptjm-57	359	25	to	to	ADP
bptjm-57	359	26	histogenetic	histogenetic	ADJ
bptjm-57	359	27	subclass	subclass	NOUN
bptjm-57	359	28	and	and	CCONJ
bptjm-57	359	29	body	body	NOUN
bptjm-57	359	30	site	site	NOUN
bptjm-57	359	31	.	.	PUNCT
bptjm-57	360	1	mol	mol	ADP
bptjm-57	360	2	oncol	oncol	ADJ
bptjm-57	360	3	.	.	PUNCT
bptjm-57	361	1	2008;1(4):395	2008;1(4):395	NUM
bptjm-57	361	2	-	-	SYM
bptjm-57	361	3	405	405	NUM
bptjm-57	361	4	.	.	PUNCT
bptjm-57	362	1	doi:10.1016	doi:10.1016	PROPN
bptjm-57	362	2	/	/	SYM
bptjm-57	362	3	j.molonc.2007.12.003	j.molonc.2007.12.003	PROPN
bptjm-57	362	4	.	.	PROPN
bptjm-57	363	1	33	33	NUM
bptjm-57	363	2	.	.	PUNCT
bptjm-57	364	1	weiss	weiss	PROPN
bptjm-57	364	2	j	j	PROPN
bptjm-57	364	3	,	,	PUNCT
bptjm-57	364	4	heine	heine	PROPN
bptjm-57	364	5	m	m	PROPN
bptjm-57	364	6	,	,	PUNCT
bptjm-57	364	7	arden	arden	PROPN
bptjm-57	364	8	kc	kc	PROPN
bptjm-57	364	9	,	,	PUNCT
bptjm-57	364	10	et	et	PROPN
bptjm-57	364	11	al	al	PROPN
bptjm-57	364	12	.	.	PROPN
bptjm-57	364	13	mutation	mutation	NOUN
bptjm-57	364	14	and	and	CCONJ
bptjm-57	364	15	expression	expression	NOUN
bptjm-57	364	16	of	of	ADP
bptjm-57	364	17	tp53	tp53	PROPN
bptjm-57	364	18	in	in	ADP
bptjm-57	364	19	malignant	malignant	ADJ
bptjm-57	364	20	melanomas.recent	melanomas.recent	NUM
bptjm-57	364	21	results	result	NOUN
bptjm-57	364	22	cancer	cancer	NOUN
bptjm-57	364	23	res	re	NOUN
bptjm-57	364	24	.	.	PUNCT
bptjm-57	364	25	1995;139:137	1995;139:137	NUM
bptjm-57	364	26	-	-	SYM
bptjm-57	364	27	154	154	NUM
bptjm-57	364	28	.	.	PUNCT
bptjm-57	365	1	doi:10.1007/978	doi:10.1007/978	ADJ
bptjm-57	365	2	-	-	PUNCT
bptjm-57	365	3	3	3	NUM
bptjm-57	365	4	-	-	PUNCT
bptjm-57	365	5	642	642	NUM
bptjm-57	365	6	-	-	PUNCT
bptjm-57	365	7	78771	78771	NUM
bptjm-57	365	8	-	-	PUNCT
bptjm-57	365	9	3_10	3_10	NUM
bptjm-57	365	10	.	.	PUNCT
bptjm-57	366	1	34	34	NUM
bptjm-57	366	2	.	.	PUNCT
bptjm-57	367	1	pawlikowska	pawlikowska	PROPN
bptjm-57	367	2	m	m	PROPN
bptjm-57	367	3	,	,	PUNCT
bptjm-57	367	4	jędrzejewski	jędrzejewski	PROPN
bptjm-57	367	5	t	t	PROPN
bptjm-57	367	6	,	,	PUNCT
bptjm-57	367	7	slominski	slominski	ADJ
bptjm-57	367	8	at	at	ADP
bptjm-57	367	9	,	,	PUNCT
bptjm-57	367	10	brożyna	brożyna	NOUN
bptjm-57	367	11	aa	aa	PROPN
bptjm-57	367	12	,	,	PUNCT
bptjm-57	367	13	wrotek	wrotek	PROPN
bptjm-57	367	14	s.	s.	PROPN
bptjm-57	367	15	pigmentation	pigmentation	PROPN
bptjm-57	367	16	levels	level	NOUN
bptjm-57	367	17	a	a	DET
bptjm-57	367	18	�	�	X
bptjm-57	367	19	ect	ect	ADJ
bptjm-57	367	20	melanoma	melanoma	NOUN
bptjm-57	367	21	responses	response	NOUN
bptjm-57	367	22	to	to	ADP
bptjm-57	367	23	coriolus	coriolus	ADJ
bptjm-57	367	24	versicolor	versicolor	NOUN
bptjm-57	367	25	extract	extract	NOUN
bptjm-57	367	26	and	and	CCONJ
bptjm-57	367	27	play	play	VERB
bptjm-57	367	28	a	a	DET
bptjm-57	367	29	crucial	crucial	ADJ
bptjm-57	367	30	role	role	NOUN
bptjm-57	367	31	in	in	ADP
bptjm-57	367	32	melanoma	melanoma	NOUN
bptjm-57	367	33	-	-	PUNCT
bptjm-57	367	34	mononuclear	mononuclear	ADJ
bptjm-57	367	35	cell	cell	NOUN
bptjm-57	367	36	crosstalk	crosstalk	NOUN
bptjm-57	367	37	.	.	PUNCT
bptjm-57	368	1	int	int	PROPN
bptjm-57	368	2	j	j	PROPN
bptjm-57	368	3	mol	mol	ADP
bptjm-57	368	4	sci	sci	PROPN
bptjm-57	368	5	.	.	PUNCT
bptjm-57	369	1	2021;22(11):5735	2021;22(11):5735	X
bptjm-57	369	2	.	.	X
bptjm-57	369	3	doi:10.3390	doi:10.3390	PROPN
bptjm-57	369	4	/	/	SYM
bptjm-57	370	1	ijms22115735	ijms22115735	PROPN
bptjm-57	370	2	.	.	PROPN
bptjm-57	371	1	35	35	NUM
bptjm-57	371	2	.	.	PUNCT
bptjm-57	371	3	brownna	brownna	PROPN
bptjm-57	371	4	,	,	PUNCT
bptjm-57	371	5	plou	plou	PROPN
bptjm-57	371	6	�	�	PROPN
bptjm-57	371	7	e	e	PROPN
bptjm-57	371	8	kr	kr	PROPN
bptjm-57	371	9	,	,	PUNCT
bptjm-57	371	10	yilmaz	yilmaz	PROPN
bptjm-57	371	11	o	o	PROPN
bptjm-57	371	12	,	,	PUNCT
bptjm-57	371	13	et	et	PROPN
bptjm-57	371	14	al	al	PROPN
bptjm-57	371	15	.	.	PUNCT
bptjm-57	372	1	tp53	tp53	PROPN
bptjm-57	372	2	mutations	mutation	NOUN
bptjm-57	372	3	and	and	CCONJ
bptjm-57	372	4	cdkn2a	cdkn2a	PROPN
bptjm-57	372	5	mutations	mutation	NOUN
bptjm-57	372	6	/	/	SYM
bptjm-57	372	7	deletions	deletion	NOUN
bptjm-57	372	8	are	be	AUX
bptjm-57	372	9	highly	highly	ADV
bptjm-57	372	10	recurrent	recurrent	ADJ
bptjm-57	372	11	molecular	molecular	ADJ
bptjm-57	372	12	alterations	alteration	NOUN
bptjm-57	372	13	in	in	ADP
bptjm-57	372	14	the	the	DET
bptjm-57	372	15	malignant	malignant	ADJ
bptjm-57	372	16	progression	progression	NOUN
bptjm-57	372	17	of	of	ADP
bptjm-57	372	18	sinonasal	sinonasal	PROPN
bptjm-57	372	19	papillomas.mod	papillomas.mod	X
bptjm-57	372	20	pathol	pathol	NOUN
bptjm-57	372	21	.	.	PUNCT
bptjm-57	373	1	2021;34(6):1133	2021;34(6):1133	NUM
bptjm-57	373	2	-	-	SYM
bptjm-57	373	3	1142	1142	NUM
bptjm-57	373	4	.	.	PUNCT
bptjm-57	374	1	doi:10.1038	doi:10.1038	NOUN
bptjm-57	374	2	/	/	SYM
bptjm-57	374	3	s41379	s41379	NOUN
bptjm-57	374	4	-	-	PUNCT
bptjm-57	374	5	020	020	NUM
bptjm-57	374	6	-	-	PUNCT
bptjm-57	374	7	00716	00716	NUM
bptjm-57	374	8	-	-	SYM
bptjm-57	374	9	3	3	NUM
bptjm-57	374	10	.	.	NUM
bptjm-57	374	11	36	36	NUM
bptjm-57	374	12	.	.	PUNCT
bptjm-57	375	1	sánchez	sánchez	NOUN
bptjm-57	375	2	-	-	PUNCT
bptjm-57	375	3	danés	danés	PROPN
bptjm-57	375	4	a	a	DET
bptjm-57	375	5	,	,	PUNCT
bptjm-57	375	6	blanpain	blanpain	ADJ
bptjm-57	375	7	c.	c.	NOUN
bptjm-57	375	8	deciphering	decipher	VERB
bptjm-57	375	9	the	the	DET
bptjm-57	375	10	cells	cell	NOUN
bptjm-57	375	11	of	of	ADP
bptjm-57	375	12	origin	origin	NOUN
bptjm-57	375	13	of	of	ADP
bptjm-57	375	14	squamous	squamous	ADJ
bptjm-57	375	15	cell	cell	NOUN
bptjm-57	375	16	carcinomas.nat	carcinomas.nat	X
bptjm-57	375	17	rev	rev	VERB
bptjm-57	375	18	cancer	cancer	NOUN
bptjm-57	375	19	.	.	PUNCT
bptjm-57	376	1	2018;18(9):549	2018;18(9):549	NUM
bptjm-57	376	2	-	-	PUNCT
bptjm-57	376	3	561	561	PROPN
bptjm-57	376	4	.	.	PUNCT
bptjm-57	377	1	doi:10.1038	doi:10.1038	NOUN
bptjm-57	377	2	/	/	SYM
bptjm-57	377	3	s41568	s41568	NOUN
bptjm-57	377	4	-	-	PUNCT
bptjm-57	377	5	018	018	NUM
bptjm-57	377	6	-	-	PUNCT
bptjm-57	377	7	0024	0024	NUM
bptjm-57	377	8	-	-	SYM
bptjm-57	377	9	5	5	NUM
bptjm-57	377	10	.	.	NOUN
bptjm-57	377	11	37	37	NUM
bptjm-57	377	12	.	.	PUNCT
bptjm-57	378	1	nagasawa	nagasawa	PROPN
bptjm-57	378	2	s	s	PROPN
bptjm-57	378	3	,	,	PUNCT
bptjm-57	378	4	kashima	kashima	PROPN
bptjm-57	378	5	y	y	PROPN
bptjm-57	378	6	,	,	PUNCT
bptjm-57	378	7	suzuki	suzuki	PROPN
bptjm-57	378	8	a	a	X
bptjm-57	378	9	,	,	PUNCT
bptjm-57	378	10	suzuki	suzuki	PROPN
bptjm-57	378	11	y.	y.	PROPN
bptjm-57	378	12	single	single	ADJ
bptjm-57	378	13	-	-	PUNCT
bptjm-57	378	14	cell	cell	NOUN
bptjm-57	378	15	and	and	CCONJ
bptjm-57	378	16	spatial	spatial	ADJ
bptjm-57	378	17	analyses	analysis	NOUN
bptjm-57	378	18	of	of	ADP
bptjm-57	378	19	cancer	cancer	NOUN
bptjm-57	378	20	cells	cell	NOUN
bptjm-57	378	21	:	:	PUNCT
bptjm-57	378	22	toward	toward	ADP
bptjm-57	378	23	elucidating	elucidate	VERB
bptjm-57	378	24	the	the	DET
bptjm-57	378	25	molecular	molecular	ADJ
bptjm-57	378	26	mechanisms	mechanism	NOUN
bptjm-57	378	27	of	of	ADP
bptjm-57	378	28	clonal	clonal	ADJ
bptjm-57	378	29	evolution	evolution	NOUN
bptjm-57	378	30	and	and	CCONJ
bptjm-57	378	31	drug	drug	NOUN
bptjm-57	378	32	resistance	resistance	NOUN
bptjm-57	378	33	acquisition	acquisition	NOUN
bptjm-57	378	34	.	.	PUNCT
bptjm-57	379	1	inflammregen	inflammregen	PROPN
bptjm-57	379	2	.	.	PUNCT
bptjm-57	380	1	2021;41(1):22	2021;41(1):22	NOUN
bptjm-57	380	2	.	.	PUNCT
bptjm-57	380	3	doi:10.1186	doi:10.1186	PROPN
bptjm-57	380	4	/	/	SYM
bptjm-57	380	5	s41232	s41232	PROPN
bptjm-57	380	6	-	-	PUNCT
bptjm-57	380	7	021	021	NUM
bptjm-57	380	8	-	-	PUNCT
bptjm-57	380	9	00170	00170	NUM
bptjm-57	380	10	-	-	PUNCT
bptjm-57	380	11	x.	x.	NOUN
bptjm-57	380	12	38	38	NUM
bptjm-57	380	13	.	.	PUNCT
bptjm-57	381	1	li	li	PROPN
bptjm-57	381	2	m	m	PROPN
bptjm-57	381	3	,	,	PUNCT
bptjm-57	381	4	zhang	zhang	PROPN
bptjm-57	381	5	z	z	PROPN
bptjm-57	381	6	,	,	PUNCT
bptjm-57	381	7	li	li	PROPN
bptjm-57	381	8	l	l	PROPN
bptjm-57	381	9	,	,	PUNCT
bptjm-57	381	10	wang	wang	PROPN
bptjm-57	381	11	x.	x.	PROPN
bptjm-57	381	12	an	an	DET
bptjm-57	381	13	algorithm	algorithm	NOUN
bptjm-57	381	14	to	to	PART
bptjm-57	381	15	quantify	quantify	VERB
bptjm-57	381	16	intratumor	intratumor	PROPN
bptjm-57	381	17	heterogeneity	heterogeneity	NOUN
bptjm-57	381	18	based	base	VERB
bptjm-57	381	19	on	on	ADP
bptjm-57	381	20	alterations	alteration	NOUN
bptjm-57	381	21	of	of	ADP
bptjm-57	381	22	gene	gene	NOUN
bptjm-57	381	23	expression	expression	NOUN
bptjm-57	381	24	pro	pro	X
bptjm-57	381	25	�	�	VERB
bptjm-57	381	26	les	le	NOUN
bptjm-57	381	27	[	[	PUNCT
bptjm-57	381	28	published	publish	VERB
bptjm-57	381	29	correction	correction	NOUN
bptjm-57	381	30	appears	appear	VERB
bptjm-57	381	31	in	in	ADP
bptjm-57	381	32	commun	commun	PROPN
bptjm-57	381	33	biol	biol	PROPN
bptjm-57	381	34	.	.	PUNCT
bptjm-57	382	1	2022mar	2022mar	NUM
bptjm-57	382	2	31;5(1):323	31;5(1):323	NUM
bptjm-57	382	3	]	]	PUNCT
bptjm-57	382	4	.	.	PUNCT
bptjm-57	383	1	commun	commun	PROPN
bptjm-57	383	2	biol	biol	PROPN
bptjm-57	383	3	.	.	PUNCT
bptjm-57	384	1	2020;3(1):505.doi:10.1038	2020;3(1):505.doi:10.1038	NUM
bptjm-57	384	2	/	/	SYM
bptjm-57	384	3	s42003	s42003	NOUN
bptjm-57	384	4	-	-	PUNCT
bptjm-57	384	5	020	020	NUM
bptjm-57	384	6	-	-	PUNCT
bptjm-57	384	7	012307	012307	NUM
bptjm-57	384	8	.	.	PUNCT
bptjm-57	385	1	39	39	NUM
bptjm-57	385	2	.	.	PUNCT
bptjm-57	386	1	song	song	PROPN
bptjm-57	386	2	d	d	PROPN
bptjm-57	386	3	,	,	PUNCT
bptjm-57	386	4	wang	wang	PROPN
bptjm-57	386	5	x.	x.	PROPN
bptjm-57	386	6	depth2	depth2	PROPN
bptjm-57	386	7	:	:	PUNCT
bptjm-57	386	8	an	an	DET
bptjm-57	386	9	mrna	mrna	NOUN
bptjm-57	386	10	-	-	PUNCT
bptjm-57	386	11	based	base	VERB
bptjm-57	386	12	algorithm	algorithm	NOUN
bptjm-57	386	13	to	to	PART
bptjm-57	386	14	evaluate	evaluate	VERB
bptjm-57	386	15	intratumor	intratumor	NOUN
bptjm-57	386	16	heterogeneity	heterogeneity	NOUN
bptjm-57	386	17	without	without	ADP
bptjm-57	386	18	reference	reference	NOUN
bptjm-57	386	19	to	to	ADP
bptjm-57	386	20	normal	normal	ADJ
bptjm-57	386	21	controls	control	NOUN
bptjm-57	386	22	.	.	PUNCT
bptjm-57	387	1	j	j	PROPN
bptjm-57	387	2	transl	transl	PROPN
bptjm-57	387	3	med	me	VERB
bptjm-57	387	4	.	.	PUNCT
bptjm-57	388	1	2022	2022	NUM
bptjm-57	388	2	apr	apr	NOUN
bptjm-57	388	3	1;20(1):150	1;20(1):150	NUM
bptjm-57	388	4	.	.	PUNCT
bptjm-57	389	1	doi	doi	NOUN
bptjm-57	389	2	:	:	PUNCT
bptjm-57	389	3	10.1186	10.1186	NUM
bptjm-57	389	4	/	/	SYM
bptjm-57	389	5	s12967	s12967	NOUN
bptjm-57	389	6	-	-	PUNCT
bptjm-57	389	7	022	022	NOUN
bptjm-57	389	8	-	-	PUNCT
bptjm-57	389	9	03355	03355	NUM
bptjm-57	389	10	-	-	SYM
bptjm-57	389	11	1	1	NUM
bptjm-57	389	12	.	.	NUM
bptjm-57	389	13	40	40	NUM
bptjm-57	389	14	.	.	PUNCT
bptjm-57	390	1	park	park	PROPN
bptjm-57	390	2	y	y	PROPN
bptjm-57	390	3	,	,	PUNCT
bptjm-57	390	4	lim	lim	PROPN
bptjm-57	390	5	s	s	PROPN
bptjm-57	390	6	,	,	PUNCT
bptjm-57	390	7	nam	nam	PROPN
bptjm-57	390	8	jw	jw	PROPN
bptjm-57	390	9	,	,	PUNCT
bptjm-57	390	10	kim	kim	PROPN
bptjm-57	390	11	s.	s.	PROPN
bptjm-57	390	12	measuring	measure	VERB
bptjm-57	390	13	intratumor	intratumor	PROPN
bptjm-57	390	14	heterogeneity	heterogeneity	NOUN
bptjm-57	390	15	by	by	ADP
bptjm-57	390	16	network	network	NOUN
bptjm-57	390	17	entropy	entropy	NOUN
bptjm-57	390	18	using	use	VERB
bptjm-57	390	19	rna	rna	NOUN
bptjm-57	390	20	-	-	PUNCT
bptjm-57	390	21	seq	seq	NOUN
bptjm-57	390	22	data	data	NOUN
bptjm-57	390	23	.	.	PUNCT
bptjm-57	391	1	sci	sci	PROPN
bptjm-57	391	2	berkeley	berkeley	PROPN
bptjm-57	391	3	pharma	pharma	PROPN
bptjm-57	391	4	tech	tech	NOUN
bptjm-57	391	5	journal	journal	NOUN
bptjm-57	391	6	of	of	ADP
bptjm-57	391	7	medicine	medicine	NOUN
bptjm-57	391	8	|	|	ADV
bptjm-57	391	9	109	109	NUM
bptjm-57	391	10	rep	rep	PROPN
bptjm-57	391	11	.	.	PROPN
bptjm-57	391	12	2016;6:37767	2016;6:37767	PROPN
bptjm-57	391	13	.	.	PUNCT
bptjm-57	392	1	doi:10.1038	doi:10.1038	NOUN
bptjm-57	392	2	/	/	SYM
bptjm-57	392	3	srep37767	srep37767	PROPN
bptjm-57	392	4	.	.	PUNCT
bptjm-57	393	1	41	41	NUM
bptjm-57	393	2	.	.	PUNCT
bptjm-57	394	1	liu	liu	PROPN
bptjm-57	394	2	c	c	PROPN
bptjm-57	394	3	,	,	PUNCT
bptjm-57	394	4	liu	liu	PROPN
bptjm-57	394	5	d	d	PROPN
bptjm-57	394	6	,	,	PUNCT
bptjm-57	394	7	wang	wang	PROPN
bptjm-57	394	8	f	f	PROPN
bptjm-57	394	9	,	,	PUNCT
bptjm-57	394	10	et	et	PROPN
bptjm-57	394	11	al	al	PROPN
bptjm-57	394	12	.	.	PUNCT
bptjm-57	395	1	an	an	DET
bptjm-57	395	2	intratumor	intratumor	ADJ
bptjm-57	395	3	heterogeneity	heterogeneity	NOUN
bptjm-57	395	4	-	-	PUNCT
bptjm-57	395	5	related	relate	VERB
bptjm-57	395	6	signature	signature	NOUN
bptjm-57	395	7	for	for	ADP
bptjm-57	395	8	predicting	predict	VERB
bptjm-57	395	9	prognosis	prognosis	NOUN
bptjm-57	395	10	,	,	PUNCT
bptjm-57	395	11	immune	immune	ADJ
bptjm-57	395	12	landscape	landscape	NOUN
bptjm-57	395	13	,	,	PUNCT
bptjm-57	395	14	and	and	CCONJ
bptjm-57	395	15	chemotherapy	chemotherapy	NOUN
bptjm-57	395	16	response	response	NOUN
bptjm-57	395	17	in	in	ADP
bptjm-57	395	18	colon	colon	NOUN
bptjm-57	395	19	adenocarcinoma	adenocarcinoma	NOUN
bptjm-57	395	20	.	.	PUNCT
bptjm-57	396	1	frontmed	frontmed	PROPN
bptjm-57	396	2	(	(	PUNCT
bptjm-57	396	3	lausanne	lausanne	PROPN
bptjm-57	396	4	)	)	PUNCT
bptjm-57	396	5	.	.	PUNCT
bptjm-57	397	1	2022;9:925661	2022;9:925661	PROPN
bptjm-57	397	2	.	.	PUNCT
bptjm-57	398	1	doi:10.3389	doi:10.3389	PROPN
bptjm-57	398	2	/	/	SYM
bptjm-57	398	3	fmed.2022.925661	fmed.2022.925661	NOUN
bptjm-57	398	4	.	.	PUNCT
bptjm-57	399	1	42	42	NUM
bptjm-57	399	2	.	.	PUNCT
bptjm-57	400	1	carter	carter	PROPN
bptjm-57	400	2	sl	sl	PROPN
bptjm-57	400	3	,	,	PUNCT
bptjm-57	400	4	cibulskis	cibulskis	PROPN
bptjm-57	400	5	k	k	PROPN
bptjm-57	400	6	,	,	PUNCT
bptjm-57	400	7	helman	helman	PROPN
bptjm-57	400	8	e	e	PROPN
bptjm-57	400	9	,	,	PUNCT
bptjm-57	400	10	et	et	PROPN
bptjm-57	400	11	al	al	PROPN
bptjm-57	400	12	.	.	PROPN
bptjm-57	401	1	absolute	absolute	PROPN
bptjm-57	401	2	quanti	quanti	PROPN
bptjm-57	401	3	�	�	PROPN
bptjm-57	401	4	cation	cation	NOUN
bptjm-57	401	5	of	of	ADP
bptjm-57	401	6	somatic	somatic	ADJ
bptjm-57	401	7	dna	dna	NOUN
bptjm-57	401	8	alterations	alteration	NOUN
bptjm-57	401	9	in	in	ADP
bptjm-57	401	10	human	human	ADJ
bptjm-57	401	11	cancer.nat	cancer.nat	NOUN
bptjm-57	401	12	biotechnol	biotechnol	NOUN
bptjm-57	401	13	.	.	PUNCT
bptjm-57	402	1	2012;30(5):413	2012;30(5):413	NUM
bptjm-57	402	2	-	-	SYM
bptjm-57	402	3	421	421	NUM
bptjm-57	402	4	.	.	PUNCT
bptjm-57	403	1	doi:10.1038	doi:10.1038	NOUN
bptjm-57	403	2	/	/	SYM
bptjm-57	403	3	nbt.2203	nbt.2203	X
bptjm-57	403	4	.	.	NOUN
bptjm-57	403	5	43	43	NUM
bptjm-57	403	6	.	.	PUNCT
bptjm-57	403	7	mroz	mroz	PROPN
bptjm-57	403	8	ea	ea	PROPN
bptjm-57	403	9	,	,	PUNCT
bptjm-57	403	10	rocco	rocco	PROPN
bptjm-57	403	11	jw.math	jw.math	NOUN
bptjm-57	403	12	,	,	PUNCT
bptjm-57	403	13	a	a	DET
bptjm-57	403	14	novel	novel	ADJ
bptjm-57	403	15	measure	measure	NOUN
bptjm-57	403	16	of	of	ADP
bptjm-57	403	17	intratumor	intratumor	ADJ
bptjm-57	403	18	genetic	genetic	ADJ
bptjm-57	403	19	heterogeneity	heterogeneity	NOUN
bptjm-57	403	20	,	,	PUNCT
bptjm-57	403	21	is	be	AUX
bptjm-57	403	22	high	high	ADJ
bptjm-57	403	23	in	in	ADP
bptjm-57	403	24	poor	poor	ADJ
bptjm-57	403	25	-	-	PUNCT
bptjm-57	403	26	outcome	outcome	NOUN
bptjm-57	403	27	classes	class	NOUN
bptjm-57	403	28	of	of	ADP
bptjm-57	403	29	head	head	NOUN
bptjm-57	403	30	and	and	CCONJ
bptjm-57	403	31	neck	neck	VERB
bptjm-57	403	32	squamous	squamous	ADJ
bptjm-57	403	33	cell	cell	NOUN
bptjm-57	403	34	carcinoma.oral	carcinoma.oral	PROPN
bptjm-57	403	35	oncol	oncol	ADJ
bptjm-57	403	36	.	.	PUNCT
bptjm-57	404	1	2013;49(3):211	2013;49(3):211	NUM
bptjm-57	404	2	-	-	SYM
bptjm-57	404	3	215	215	NUM
bptjm-57	404	4	.	.	PUNCT
bptjm-57	404	5	doi:10.1016	doi:10.1016	PROPN
bptjm-57	404	6	/	/	SYM
bptjm-57	404	7	j.oraloncology.2012.09.007	j.oraloncology.2012.09.007	NOUN
bptjm-57	404	8	.	.	PUNCT
bptjm-57	405	1	44	44	NUM
bptjm-57	405	2	.	.	PUNCT
bptjm-57	406	1	andor	andor	PROPN
bptjm-57	406	2	n	n	CCONJ
bptjm-57	406	3	,	,	PUNCT
bptjm-57	406	4	harness	harness	NOUN
bptjm-57	406	5	jv	jv	NOUN
bptjm-57	406	6	,	,	PUNCT
bptjm-57	406	7	müller	müller	PROPN
bptjm-57	406	8	s	s	PROPN
bptjm-57	406	9	,	,	PUNCT
bptjm-57	406	10	mewes	mewes	PROPN
bptjm-57	406	11	hw	hw	PROPN
bptjm-57	406	12	,	,	PUNCT
bptjm-57	406	13	petritsch	petritsch	PROPN
bptjm-57	406	14	c.	c.	PROPN
bptjm-57	406	15	expands	expand	VERB
bptjm-57	406	16	:	:	PUNCT
bptjm-57	406	17	expanding	expand	VERB
bptjm-57	406	18	ploidy	ploidy	ADJ
bptjm-57	406	19	and	and	CCONJ
bptjm-57	406	20	allele	allele	NOUN
bptjm-57	406	21	frequency	frequency	NOUN
bptjm-57	406	22	on	on	ADP
bptjm-57	406	23	nested	nested	ADJ
bptjm-57	406	24	subpopulations	subpopulation	NOUN
bptjm-57	406	25	.	.	PUNCT
bptjm-57	407	1	bioinformatics	bioinformatics	NOUN
bptjm-57	407	2	.	.	PUNCT
bptjm-57	408	1	2014;30(1):50	2014;30(1):50	NUM
bptjm-57	408	2	-	-	SYM
bptjm-57	408	3	60	60	NUM
bptjm-57	408	4	.	.	PUNCT
bptjm-57	408	5	doi:10.1093	doi:10.1093	NOUN
bptjm-57	408	6	/	/	SYM
bptjm-57	408	7	bioinformatics	bioinformatics	NOUN
bptjm-57	408	8	/	/	SYM
bptjm-57	408	9	btt622	btt622	PROPN
bptjm-57	408	10	.	.	PUNCT
bptjm-57	409	1	45	45	NUM
bptjm-57	409	2	.	.	PUNCT
bptjm-57	409	3	deshwar	deshwar	PROPN
bptjm-57	409	4	ag	ag	PROPN
bptjm-57	409	5	,	,	PUNCT
bptjm-57	409	6	vembu	vembu	VERB
bptjm-57	409	7	s	s	NOUN
bptjm-57	409	8	,	,	PUNCT
bptjm-57	409	9	yung	yung	PROPN
bptjm-57	409	10	ck	ck	PROPN
bptjm-57	409	11	,	,	PUNCT
bptjm-57	409	12	jang	jang	PROPN
bptjm-57	409	13	gh	gh	PROPN
bptjm-57	409	14	,	,	PUNCT
bptjm-57	409	15	stein	stein	PROPN
bptjm-57	409	16	l	l	PROPN
bptjm-57	409	17	,	,	PUNCT
bptjm-57	409	18	morris	morris	PROPN
bptjm-57	409	19	q.	q.	PROPN
bptjm-57	409	20	phylowgs	phylowgs	PROPN
bptjm-57	409	21	:	:	PUNCT
bptjm-57	409	22	reconstructing	reconstruct	VERB
bptjm-57	409	23	subclonal	subclonal	ADJ
bptjm-57	409	24	composition	composition	NOUN
bptjm-57	409	25	and	and	CCONJ
bptjm-57	409	26	evolution	evolution	NOUN
bptjm-57	409	27	from	from	ADP
bptjm-57	409	28	whole	whole	ADJ
bptjm-57	409	29	-	-	PUNCT
bptjm-57	409	30	genome	genome	NOUN
bptjm-57	409	31	sequencing	sequencing	NOUN
bptjm-57	409	32	of	of	ADP
bptjm-57	409	33	tumors.genome	tumors.genome	NUM
bptjm-57	409	34	biol	biol	NOUN
bptjm-57	409	35	.	.	PUNCT
bptjm-57	410	1	2015;16(1):35	2015;16(1):35	X
bptjm-57	410	2	.	.	PUNCT
bptjm-57	411	1	doi:10.1186	doi:10.1186	PROPN
bptjm-57	411	2	/	/	SYM
bptjm-57	411	3	s13059	s13059	PROPN
bptjm-57	411	4	-	-	PUNCT
bptjm-57	411	5	015	015	NUM
bptjm-57	411	6	-	-	PUNCT
bptjm-57	411	7	0602	0602	NUM
bptjm-57	411	8	-	-	SYM
bptjm-57	411	9	8	8	NUM
bptjm-57	411	10	.	.	NOUN
bptjm-57	411	11	46	46	NUM
bptjm-57	411	12	.	.	PUNCT
bptjm-57	412	1	ding	ding	PROPN
bptjm-57	412	2	s	s	PROPN
bptjm-57	412	3	,	,	PUNCT
bptjm-57	412	4	chen	chen	PROPN
bptjm-57	412	5	x	x	PROPN
bptjm-57	412	6	,	,	PUNCT
bptjm-57	412	7	shen	shen	PROPN
bptjm-57	412	8	k.	k.	PROPN
bptjm-57	412	9	single	single	ADJ
bptjm-57	412	10	-	-	PUNCT
bptjm-57	412	11	cell	cell	NOUN
bptjm-57	412	12	rna	rna	NOUN
bptjm-57	412	13	sequencing	sequencing	NOUN
bptjm-57	412	14	in	in	ADP
bptjm-57	412	15	breast	breast	NOUN
bptjm-57	412	16	cancer	cancer	NOUN
bptjm-57	412	17	:	:	PUNCT
bptjm-57	412	18	understanding	understand	VERB
bptjm-57	412	19	tumor	tumor	NOUN
bptjm-57	412	20	heterogeneity	heterogeneity	NOUN
bptjm-57	412	21	and	and	CCONJ
bptjm-57	412	22	paving	pave	VERB
bptjm-57	412	23	roads	road	NOUN
bptjm-57	412	24	to	to	ADP
bptjm-57	412	25	individualized	individualized	ADJ
bptjm-57	412	26	therapy	therapy	NOUN
bptjm-57	412	27	.	.	PUNCT
bptjm-57	413	1	cancer	cancer	NOUN
bptjm-57	413	2	commun	commun	PROPN
bptjm-57	413	3	(	(	PUNCT
bptjm-57	413	4	lond	lond	PROPN
bptjm-57	413	5	)	)	PUNCT
bptjm-57	413	6	.	.	PUNCT
bptjm-57	414	1	2020;40(8):329	2020;40(8):329	PROPN
bptjm-57	414	2	-	-	PUNCT
bptjm-57	414	3	344	344	NUM
bptjm-57	414	4	.	.	PUNCT
bptjm-57	415	1	doi:10.1002	doi:10.1002	NOUN
bptjm-57	415	2	/	/	SYM
bptjm-57	415	3	cac2.12078	cac2.12078	PROPN
bptjm-57	415	4	.	.	PUNCT
bptjm-57	416	1	47	47	NUM
bptjm-57	416	2	.	.	PUNCT
bptjm-57	417	1	kim	kim	PROPN
bptjm-57	417	2	c	c	PROPN
bptjm-57	417	3	,	,	PUNCT
bptjm-57	417	4	gao	gao	PROPN
bptjm-57	417	5	r	r	PROPN
bptjm-57	417	6	,	,	PUNCT
bptjm-57	417	7	sei	sei	ADJ
bptjm-57	417	8	e	e	NOUN
bptjm-57	417	9	,	,	PUNCT
bptjm-57	417	10	et	et	PROPN
bptjm-57	417	11	al	al	PROPN
bptjm-57	417	12	.	.	PROPN
bptjm-57	417	13	chemoresistance	chemoresistance	PROPN
bptjm-57	417	14	evolution	evolution	NOUN
bptjm-57	417	15	in	in	ADP
bptjm-57	417	16	triple	triple	ADJ
bptjm-57	417	17	-	-	PUNCT
bptjm-57	417	18	negative	negative	ADJ
bptjm-57	417	19	breast	breast	NOUN
bptjm-57	417	20	cancer	cancer	NOUN
bptjm-57	417	21	delineated	delineate	VERB
bptjm-57	417	22	by	by	ADP
bptjm-57	417	23	single	single	ADJ
bptjm-57	417	24	-	-	PUNCT
bptjm-57	417	25	cell	cell	NOUN
bptjm-57	417	26	sequencing	sequencing	NOUN
bptjm-57	417	27	.	.	PUNCT
bptjm-57	418	1	cell	cell	NOUN
bptjm-57	418	2	.	.	PUNCT
bptjm-57	419	1	2018;173(4):879	2018;173(4):879	NUM
bptjm-57	419	2	-	-	SYM
bptjm-57	419	3	893.e13	893.e13	NUM
bptjm-57	419	4	.	.	PUNCT
bptjm-57	419	5	doi:10.1016	doi:10.1016	PROPN
bptjm-57	419	6	/	/	SYM
bptjm-57	419	7	j.cell.2018.03.041	j.cell.2018.03.041	PROPN
bptjm-57	419	8	.	.	PROPN
bptjm-57	420	1	48	48	NUM
bptjm-57	420	2	.	.	X
bptjm-57	420	3	vanhaesebroeck	vanhaesebroeck	PROPN
bptjm-57	420	4	,	,	PUNCT
bptjm-57	420	5	b.	b.	PROPN
bptjm-57	420	6	,	,	PUNCT
bptjm-57	420	7	perry	perry	PROPN
bptjm-57	420	8	,	,	PUNCT
bptjm-57	420	9	m.w	m.w	PROPN
bptjm-57	420	10	.	.	PROPN
bptjm-57	420	11	d.	d.	PROPN
bptjm-57	420	12	,	,	PUNCT
bptjm-57	420	13	brown	brown	PROPN
bptjm-57	420	14	,	,	PUNCT
bptjm-57	420	15	j.	j.	PROPN
bptjm-57	420	16	r.	r.	PROPN
bptjm-57	420	17	,	,	PUNCT
bptjm-57	420	18	andré	andré	VERB
bptjm-57	420	19	,	,	PUNCT
bptjm-57	420	20	f.	f.	PROPN
bptjm-57	420	21	,	,	PUNCT
bptjm-57	420	22	&	&	CCONJ
bptjm-57	420	23	okkenhaug	okkenhaug	PROPN
bptjm-57	420	24	,	,	PUNCT
bptjm-57	420	25	k.	k.	PROPN
bptjm-57	420	26	pi3k	pi3k	PROPN
bptjm-57	420	27	inhibitors	inhibitor	NOUN
bptjm-57	420	28	are	be	AUX
bptjm-57	420	29	�	�	PRON
bptjm-57	420	30	nally	nally	ADV
bptjm-57	420	31	coming	come	VERB
bptjm-57	420	32	of	of	ADP
bptjm-57	420	33	age.nat	age.nat	PROPN
bptjm-57	420	34	rev	rev	VERB
bptjm-57	420	35	drug	drug	NOUN
bptjm-57	420	36	discov	discov	NOUN
bptjm-57	420	37	.	.	PUNCT
bptjm-57	421	1	2021;20(10	2021;20(10	NUM
bptjm-57	421	2	)	)	PUNCT
bptjm-57	421	3	,	,	PUNCT
bptjm-57	422	1	741–769	741–769	NUM
bptjm-57	422	2	.	.	PUNCT
bptjm-57	422	3	doi:10.1038	doi:10.1038	NOUN
bptjm-57	422	4	/	/	SYM
bptjm-57	422	5	s41573	s41573	PROPN
bptjm-57	422	6	-	-	PUNCT
bptjm-57	422	7	021	021	NUM
bptjm-57	422	8	-	-	PUNCT
bptjm-57	422	9	00209	00209	NUM
bptjm-57	422	10	-	-	PUNCT
bptjm-57	422	11	1	1	NUM
bptjm-57	422	12	.	.	NUM
bptjm-57	422	13	49	49	NUM
bptjm-57	422	14	.	.	PUNCT
bptjm-57	423	1	hobor	hobor	PROPN
bptjm-57	423	2	s	s	PROPN
bptjm-57	423	3	,	,	PUNCT
bptjm-57	423	4	van	van	PROPN
bptjm-57	423	5	emburgh	emburgh	PROPN
bptjm-57	423	6	bo	bo	PROPN
bptjm-57	423	7	,	,	PUNCT
bptjm-57	423	8	crowley	crowley	PROPN
bptjm-57	423	9	e	e	PROPN
bptjm-57	423	10	,	,	PUNCT
bptjm-57	423	11	misale	misale	VERB
bptjm-57	423	12	s	s	PROPN
bptjm-57	423	13	,	,	PUNCT
bptjm-57	423	14	di	di	NOUN
bptjm-57	423	15	nicolantonio	nicolantonio	NOUN
bptjm-57	423	16	f	f	PROPN
bptjm-57	423	17	,	,	PUNCT
bptjm-57	423	18	bardelli	bardelli	NOUN
bptjm-57	423	19	a.	a.	NOUN
bptjm-57	423	20	tgfα	tgfα	PROPN
bptjm-57	423	21	and	and	CCONJ
bptjm-57	423	22	amphiregulin	amphiregulin	ADJ
bptjm-57	423	23	paracrine	paracrine	NOUN
bptjm-57	423	24	network	network	NOUN
bptjm-57	423	25	promotes	promote	VERB
bptjm-57	423	26	resistance	resistance	NOUN
bptjm-57	423	27	to	to	ADP
bptjm-57	423	28	egfr	egfr	VERB
bptjm-57	423	29	blockade	blockade	NOUN
bptjm-57	423	30	in	in	ADP
bptjm-57	423	31	colorectal	colorectal	ADJ
bptjm-57	423	32	cancer	cancer	NOUN
bptjm-57	423	33	cells	cell	NOUN
bptjm-57	423	34	.	.	PUNCT
bptjm-57	424	1	clin	clin	PROPN
bptjm-57	424	2	cancer	cancer	NOUN
bptjm-57	424	3	res	re	NOUN
bptjm-57	424	4	.	.	PUNCT
bptjm-57	425	1	2014;20(24):6429	2014;20(24):6429	PROPN
bptjm-57	425	2	-	-	SYM
bptjm-57	425	3	6438	6438	NUM
bptjm-57	425	4	.	.	PUNCT
bptjm-57	426	1	doi:10.1158/1078	doi:10.1158/1078	ADV
bptjm-57	426	2	-	-	PUNCT
bptjm-57	426	3	0432.ccr-14	0432.ccr-14	NUM
bptjm-57	426	4	-	-	PUNCT
bptjm-57	426	5	0774	0774	NUM
bptjm-57	426	6	.	.	PUNCT
bptjm-57	427	1	50	50	NUM
bptjm-57	427	2	.	.	PUNCT
bptjm-57	427	3	national	national	PROPN
bptjm-57	427	4	cancer	cancer	PROPN
bptjm-57	427	5	institute	institute	PROPN
bptjm-57	427	6	.	.	PUNCT
bptjm-57	428	1	immunotherapy	immunotherapy	NOUN
bptjm-57	428	2	.	.	PUNCT
bptjm-57	429	1	national	national	PROPN
bptjm-57	429	2	cancer	cancer	PROPN
bptjm-57	429	3	institute	institute	PROPN
bptjm-57	429	4	.	.	PUNCT
bptjm-57	430	1	published	publish	VERB
bptjm-57	430	2	september	september	PROPN
bptjm-57	430	3	24	24	NUM
bptjm-57	430	4	,	,	PUNCT
bptjm-57	430	5	2019	2019	NUM
bptjm-57	430	6	.	.	PUNCT
bptjm-57	431	1	accessed	access	VERB
bptjm-57	431	2	august	august	PROPN
bptjm-57	431	3	11	11	NUM
bptjm-57	431	4	,	,	PUNCT
bptjm-57	431	5	2023	2023	NUM
bptjm-57	431	6	.	.	PUNCT
bptjm-57	432	1	https://www.cancer.gov/about-cancer/treat	https://www.cancer.gov/about-cancer/treat	PROPN
bptjm-57	432	2	ment	ment	PROPN
bptjm-57	432	3	/	/	SYM
bptjm-57	432	4	types	type	NOUN
bptjm-57	432	5	/	/	SYM
bptjm-57	432	6	immunotherapy	immunotherapy	NOUN
bptjm-57	432	7	.	.	PUNCT
bptjm-57	433	1	51	51	NUM
bptjm-57	433	2	.	.	PUNCT
bptjm-57	434	1	asmamawdejenie	asmamawdejenie	PROPN
bptjm-57	434	2	t	t	PROPN
bptjm-57	434	3	,	,	PUNCT
bptjm-57	434	4	tiruneh	tiruneh	PROPN
bptjm-57	434	5	g	g	PROPN
bptjm-57	434	6	/	/	SYM
bptjm-57	434	7	medhinm	medhinm	PROPN
bptjm-57	434	8	,	,	PUNCT
bptjm-57	434	9	dessie	dessie	PROPN
bptjm-57	434	10	terefe	terefe	PROPN
bptjm-57	434	11	g	g	PROPN
bptjm-57	434	12	,	,	PUNCT
bptjm-57	434	13	tadele	tadele	PROPN
bptjm-57	434	14	admasu	admasu	PROPN
bptjm-57	434	15	f	f	PROPN
bptjm-57	434	16	,	,	PUNCT
bptjm-57	434	17	wale	wale	PROPN
bptjm-57	434	18	tesega	tesega	PROPN
bptjm-57	434	19	w	w	PROPN
bptjm-57	434	20	,	,	PUNCT
bptjm-57	434	21	chekol	chekol	NOUN
bptjm-57	434	22	abebe	abebe	PROPN
bptjm-57	434	23	e.	e.	PROPN
bptjm-57	434	24	current	current	PROPN
bptjm-57	434	25	updates	update	NOUN
bptjm-57	434	26	on	on	ADP
bptjm-57	434	27	generations	generation	NOUN
bptjm-57	434	28	,	,	PUNCT
bptjm-57	434	29	approvals	approval	NOUN
bptjm-57	434	30	,	,	PUNCT
bptjm-57	434	31	and	and	CCONJ
bptjm-57	434	32	clinical	clinical	ADJ
bptjm-57	434	33	trials	trial	NOUN
bptjm-57	434	34	of	of	ADP
bptjm-57	434	35	cart	cart	NOUN
bptjm-57	434	36	-	-	PUNCT
bptjm-57	434	37	cell	cell	NOUN
bptjm-57	434	38	therapy	therapy	NOUN
bptjm-57	434	39	.	.	PUNCT
bptjm-57	435	1	humvaccin	humvaccin	PROPN
bptjm-57	435	2	immunother	immunother	PROPN
bptjm-57	435	3	.	.	PUNCT
bptjm-57	436	1	2022;18(6):2114254	2022;18(6):2114254	NUM
bptjm-57	436	2	.	.	PUNCT
bptjm-57	437	1	doi:10.1080/21645515.2022.2114254	doi:10.1080/21645515.2022.2114254	PROPN
bptjm-57	437	2	.	.	PROPN
bptjm-57	438	1	52	52	NUM
bptjm-57	438	2	.	.	PUNCT
bptjm-57	438	3	ctg	ctg	PROPN
bptjm-57	438	4	labs	labs	PROPN
bptjm-57	438	5	ncbi	ncbi	PROPN
bptjm-57	438	6	.	.	PUNCT
bptjm-57	439	1	clinicaltrials.gov	clinicaltrials.gov	X
bptjm-57	439	2	.	.	PROPN
bptjm-57	439	3	accessed	access	VERB
bptjm-57	439	4	july	july	PROPN
bptjm-57	439	5	27	27	NUM
bptjm-57	439	6	,	,	PUNCT
bptjm-57	439	7	2023	2023	NUM
bptjm-57	439	8	.	.	PUNCT
bptjm-57	440	1	https://clinicaltrials.gov/study/nct02706392	https://clinicaltrials.gov/study/nct02706392	PROPN
bptjm-57	440	2	.	.	PROPN
bptjm-57	441	1	53	53	NUM
bptjm-57	441	2	.	.	PUNCT
bptjm-57	442	1	kirtane	kirtane	PROPN
bptjm-57	442	2	k	k	PROPN
bptjm-57	442	3	,	,	PUNCT
bptjm-57	442	4	elmariah	elmariah	PROPN
bptjm-57	442	5	h	h	NOUN
bptjm-57	442	6	,	,	PUNCT
bptjm-57	442	7	chung	chung	PROPN
bptjm-57	442	8	ch	ch	PROPN
bptjm-57	442	9	,	,	PUNCT
bptjm-57	442	10	abate	abate	NOUN
bptjm-57	442	11	-	-	PUNCT
bptjm-57	442	12	daga	daga	NOUN
bptjm-57	442	13	d.	d.	PROPN
bptjm-57	442	14	adoptive	adoptive	ADJ
bptjm-57	442	15	cellular	cellular	PROPN
bptjm-57	442	16	therapy	therapy	NOUN
bptjm-57	442	17	in	in	ADP
bptjm-57	442	18	solid	solid	ADJ
bptjm-57	442	19	tumor	tumor	NOUN
bptjm-57	442	20	malignancies	malignancy	NOUN
bptjm-57	442	21	:	:	PUNCT
bptjm-57	442	22	review	review	NOUN
bptjm-57	442	23	of	of	ADP
bptjm-57	442	24	the	the	DET
bptjm-57	442	25	literature	literature	NOUN
bptjm-57	442	26	and	and	CCONJ
bptjm-57	442	27	challenges	challenge	NOUN
bptjm-57	442	28	ahead	ahead	ADV
bptjm-57	442	29	.	.	PUNCT
bptjm-57	443	1	j	j	PROPN
bptjm-57	443	2	immunother	immunother	ADJ
bptjm-57	443	3	cancer	cancer	NOUN
bptjm-57	443	4	.	.	PUNCT
bptjm-57	444	1	2021;9(7):e002723	2021;9(7):e002723	PROPN
bptjm-57	444	2	.	.	PUNCT
bptjm-57	444	3	doi:10.1136	doi:10.1136	NOUN
bptjm-57	444	4	/	/	SYM
bptjm-57	444	5	jitc-2021	jitc-2021	NOUN
bptjm-57	444	6	-	-	PUNCT
bptjm-57	444	7	002723	002723	NUM
bptjm-57	444	8	.	.	PUNCT
bptjm-57	445	1	berkeley	berkeley	PROPN
bptjm-57	445	2	pharma	pharma	PROPN
bptjm-57	445	3	tech	tech	PROPN
bptjm-57	445	4	journal	journal	NOUN
bptjm-57	445	5	of	of	ADP
bptjm-57	445	6	medicine	medicine	NOUN
bptjm-57	445	7	|	|	ADV
bptjm-57	445	8	110	110	NUM
bptjm-57	445	9	54	54	NUM
bptjm-57	445	10	.	.	PUNCT
bptjm-57	446	1	yang	yang	PROPN
bptjm-57	446	2	f	f	PROPN
bptjm-57	446	3	,	,	PUNCT
bptjm-57	446	4	zhang	zhang	PROPN
bptjm-57	446	5	f	f	PROPN
bptjm-57	446	6	,	,	PUNCT
bptjm-57	446	7	ji	ji	PROPN
bptjm-57	446	8	f	f	PROPN
bptjm-57	446	9	,	,	PUNCT
bptjm-57	446	10	et	et	PROPN
bptjm-57	446	11	al	al	PROPN
bptjm-57	446	12	.	.	PROPN
bptjm-57	446	13	self	self	NOUN
bptjm-57	446	14	-	-	PUNCT
bptjm-57	446	15	delivery	delivery	NOUN
bptjm-57	446	16	of	of	ADP
bptjm-57	446	17	tigit	tigit	NOUN
bptjm-57	446	18	-	-	PUNCT
bptjm-57	446	19	blocking	block	VERB
bptjm-57	446	20	scfv	scfv	NOUN
bptjm-57	446	21	enhances	enhance	VERB
bptjm-57	446	22	car	car	NOUN
bptjm-57	446	23	-	-	PUNCT
bptjm-57	446	24	t	t	NOUN
bptjm-57	446	25	immunotherapy	immunotherapy	NOUN
bptjm-57	446	26	in	in	ADP
bptjm-57	446	27	solid	solid	ADJ
bptjm-57	446	28	tumors	tumor	NOUN
bptjm-57	446	29	.	.	PUNCT
bptjm-57	447	1	front	front	ADJ
bptjm-57	447	2	immunol	immunol	NOUN
bptjm-57	447	3	.	.	PUNCT
bptjm-57	448	1	2023;14:1175920	2023;14:1175920	X
bptjm-57	448	2	.	.	PUNCT
bptjm-57	449	1	doi:10.3389/	doi:10.3389/	PROPN
bptjm-57	449	2	�	�	PROPN
bptjm-57	449	3	mmu.2023.1175920	mmu.2023.1175920	NUM
bptjm-57	449	4	.	.	PUNCT
bptjm-57	450	1	55	55	NUM
bptjm-57	450	2	.	.	PUNCT
bptjm-57	451	1	ctg	ctg	PROPN
bptjm-57	451	2	labs	labs	PROPN
bptjm-57	451	3	ncbi	ncbi	PROPN
bptjm-57	451	4	.	.	PUNCT
bptjm-57	452	1	clinicaltrials.gov	clinicaltrials.gov	X
bptjm-57	452	2	.	.	PROPN
bptjm-57	452	3	accessed	access	VERB
bptjm-57	452	4	july	july	PROPN
bptjm-57	452	5	27	27	NUM
bptjm-57	452	6	,	,	PUNCT
bptjm-57	452	7	2023	2023	NUM
bptjm-57	452	8	.	.	PUNCT
bptjm-57	453	1	https://clinicaltrials.gov/study/nct03873805	https://clinicaltrials.gov/study/nct03873805	PROPN
bptjm-57	453	2	56	56	NUM
bptjm-57	453	3	.	.	PUNCT
bptjm-57	453	4	naimi	naimi	PROPN
bptjm-57	453	5	a	a	PROPN
bptjm-57	453	6	,	,	PUNCT
bptjm-57	453	7	mohammed	mohammed	PROPN
bptjm-57	453	8	rn	rn	PROPN
bptjm-57	453	9	,	,	PUNCT
bptjm-57	453	10	raji	raji	PROPN
bptjm-57	453	11	a	a	PROPN
bptjm-57	453	12	,	,	PUNCT
bptjm-57	453	13	et	et	PROPN
bptjm-57	453	14	al	al	PROPN
bptjm-57	453	15	.	.	PUNCT
bptjm-57	454	1	tumor	tumor	PROPN
bptjm-57	454	2	immunotherapies	immunotherapy	NOUN
bptjm-57	454	3	by	by	ADP
bptjm-57	454	4	immune	immune	ADJ
bptjm-57	454	5	checkpoint	checkpoint	NOUN
bptjm-57	454	6	inhibitors	inhibitor	NOUN
bptjm-57	454	7	(	(	PUNCT
bptjm-57	454	8	icis	icis	PROPN
bptjm-57	454	9	)	)	PUNCT
bptjm-57	454	10	;	;	PUNCT
bptjm-57	454	11	the	the	DET
bptjm-57	454	12	pros	pro	NOUN
bptjm-57	454	13	and	and	CCONJ
bptjm-57	454	14	cons	con	NOUN
bptjm-57	454	15	.	.	PUNCT
bptjm-57	455	1	cell	cell	NOUN
bptjm-57	455	2	commun	commun	PROPN
bptjm-57	455	3	signal	signal	PROPN
bptjm-57	455	4	.	.	PUNCT
bptjm-57	456	1	2022;20(1):44	2022;20(1):44	X
bptjm-57	456	2	.	.	PUNCT
bptjm-57	456	3	doi:10.1186	doi:10.1186	PROPN
bptjm-57	456	4	/	/	SYM
bptjm-57	456	5	s12964	s12964	NOUN
bptjm-57	456	6	-	-	PUNCT
bptjm-57	456	7	022	022	NUM
bptjm-57	456	8	-	-	PUNCT
bptjm-57	456	9	00854	00854	NUM
bptjm-57	456	10	-	-	PUNCT
bptjm-57	456	11	y.	y.	NOUN
bptjm-57	456	12	57	57	NUM
bptjm-57	456	13	.	.	PUNCT
bptjm-57	457	1	ctg	ctg	PROPN
bptjm-57	457	2	labs	labs	PROPN
bptjm-57	457	3	ncbi	ncbi	PROPN
bptjm-57	457	4	.	.	PUNCT
bptjm-57	458	1	clinicaltrials.gov	clinicaltrials.gov	X
bptjm-57	458	2	.	.	NOUN
bptjm-57	458	3	accessed	access	VERB
bptjm-57	458	4	august	august	PROPN
bptjm-57	458	5	8	8	NUM
bptjm-57	458	6	,	,	PUNCT
bptjm-57	458	7	2023	2023	NUM
bptjm-57	458	8	.	.	PUNCT
bptjm-57	459	1	https://clinicaltrials.gov/study/nct0289929	https://clinicaltrials.gov/study/nct0289929	PROPN
bptjm-57	459	2	9?term	9?term	NUM
bptjm-57	459	3	=	=	SYM
bptjm-57	459	4	nct02899299&rank=1&tab	nct02899299&rank=1&tab	NOUN
bptjm-57	459	5	=	=	NOUN
bptjm-57	459	6	result	result	NOUN
bptjm-57	459	7	s	s	VERB
bptjm-57	459	8	58	58	NUM
bptjm-57	459	9	.	.	PUNCT
bptjm-57	460	1	first	first	ADJ
bptjm-57	460	2	-	-	PUNCT
bptjm-57	460	3	line	line	NOUN
bptjm-57	460	4	nivolumab	nivolumab	NOUN
bptjm-57	460	5	plus	plus	CCONJ
bptjm-57	460	6	ipilimumab	ipilimumab	NOUN
bptjm-57	460	7	versus	versus	ADP
bptjm-57	460	8	chemotherapy	chemotherapy	NOUN
bptjm-57	460	9	in	in	ADP
bptjm-57	460	10	patients	patient	NOUN
bptjm-57	460	11	with	with	ADP
bptjm-57	460	12	unresectable	unresectable	ADJ
bptjm-57	460	13	malignant	malignant	ADJ
bptjm-57	460	14	pleural	pleural	ADJ
bptjm-57	460	15	mesothelioma	mesothelioma	NOUN
bptjm-57	460	16	:	:	PUNCT
bptjm-57	460	17	3	3	NUM
bptjm-57	460	18	-	-	PUNCT
bptjm-57	460	19	year	year	NOUN
bptjm-57	460	20	outcomes	outcome	NOUN
bptjm-57	460	21	from	from	ADP
bptjm-57	460	22	checkmate	checkmate	VERB
bptjm-57	460	23	743	743	NUM
bptjm-57	460	24	.	.	PUNCT
bptjm-57	461	1	ann	ann	PROPN
bptjm-57	461	2	oncol	oncol	PROPN
bptjm-57	461	3	.	.	PUNCT
bptjm-57	462	1	2022;33(5):488	2022;33(5):488	PROPN
bptjm-57	462	2	-	-	PUNCT
bptjm-57	462	3	499	499	NUM
bptjm-57	462	4	.	.	PUNCT
bptjm-57	463	1	doi:10.1016	doi:10.1016	PROPN
bptjm-57	463	2	/	/	SYM
bptjm-57	463	3	j.annonc.2022.01.074	j.annonc.2022.01.074	PROPN
bptjm-57	463	4	.	.	PROPN
bptjm-57	464	1	59	59	NUM
bptjm-57	464	2	.	.	PUNCT
bptjm-57	465	1	bayat	bayat	VERB
bptjm-57	465	2	mokhtari	mokhtari	PROPN
bptjm-57	465	3	r	r	PROPN
bptjm-57	465	4	,	,	PUNCT
bptjm-57	465	5	homayouni	homayouni	PROPN
bptjm-57	465	6	ts	ts	PROPN
bptjm-57	465	7	,	,	PUNCT
bptjm-57	465	8	baluch	baluch	PROPN
bptjm-57	465	9	n	n	CCONJ
bptjm-57	465	10	,	,	PUNCT
bptjm-57	465	11	et	et	PROPN
bptjm-57	465	12	al	al	PROPN
bptjm-57	465	13	.	.	PROPN
bptjm-57	465	14	combination	combination	NOUN
bptjm-57	465	15	therapy	therapy	NOUN
bptjm-57	465	16	in	in	ADP
bptjm-57	465	17	combating	combat	VERB
bptjm-57	465	18	cancer.oncotarget	cancer.oncotarget	NOUN
bptjm-57	465	19	.	.	PUNCT
bptjm-57	466	1	2017;8(23):38022	2017;8(23):38022	NUM
bptjm-57	466	2	-	-	SYM
bptjm-57	466	3	38043	38043	NUM
bptjm-57	466	4	.	.	PUNCT
bptjm-57	467	1	doi:10.18632	doi:10.18632	PROPN
bptjm-57	467	2	/	/	SYM
bptjm-57	467	3	oncotarget.16723	oncotarget.16723	PROPN
bptjm-57	467	4	.	.	PROPN
bptjm-57	467	5	60	60	NUM
bptjm-57	467	6	.	.	PUNCT
bptjm-57	468	1	nguyen	nguyen	PROPN
bptjm-57	468	2	a	a	X
bptjm-57	468	3	,	,	PUNCT
bptjm-57	468	4	ho	ho	PROPN
bptjm-57	468	5	la	la	PROPN
bptjm-57	468	6	,	,	PUNCT
bptjm-57	468	7	workenhe	workenhe	PROPN
bptjm-57	468	8	st	st	PROPN
bptjm-57	468	9	,	,	PUNCT
bptjm-57	468	10	et	et	PROPN
bptjm-57	468	11	al	al	PROPN
bptjm-57	468	12	.	.	PROPN
bptjm-57	469	1	hdaci	hdaci	NOUN
bptjm-57	469	2	delivery	delivery	NOUN
bptjm-57	469	3	reprograms	reprogram	VERB
bptjm-57	469	4	tumor	tumor	NOUN
bptjm-57	469	5	-	-	PUNCT
bptjm-57	469	6	in	in	ADP
bptjm-57	469	7	�	�	NOUN
bptjm-57	469	8	ltrating	ltrate	VERB
bptjm-57	469	9	myeloid	myeloid	ADJ
bptjm-57	469	10	cells	cell	NOUN
bptjm-57	469	11	to	to	PART
bptjm-57	469	12	eliminate	eliminate	VERB
bptjm-57	469	13	antigen	antigen	NOUN
bptjm-57	469	14	-	-	PUNCT
bptjm-57	469	15	loss	loss	NOUN
bptjm-57	469	16	variants	variant	NOUN
bptjm-57	469	17	.	.	PUNCT
bptjm-57	470	1	cell	cell	NOUN
bptjm-57	470	2	reports	report	NOUN
bptjm-57	470	3	.	.	PUNCT
bptjm-57	471	1	2018;24(3):642	2018;24(3):642	NUM
bptjm-57	471	2	-	-	SYM
bptjm-57	471	3	654	654	NUM
bptjm-57	471	4	.	.	PUNCT
bptjm-57	472	1	doi	doi	NOUN
bptjm-57	472	2	:	:	PUNCT
bptjm-57	472	3	https://doi.org/10.1016	https://doi.org/10.1016	NOUN
bptjm-57	472	4	/	/	SYM
bptjm-57	472	5	j.celrep.2018.06.0	j.celrep.2018.06.0	NOUN
bptjm-57	472	6	40	40	NUM
bptjm-57	472	7	.	.	PUNCT
bptjm-57	472	8	61	61	NUM
bptjm-57	472	9	.	.	X
bptjm-57	473	1	ariyan	ariyan	PROPN
bptjm-57	473	2	ce	ce	PROPN
bptjm-57	473	3	,	,	PUNCT
bptjm-57	473	4	bradyms	bradyms	PROPN
bptjm-57	473	5	,	,	PUNCT
bptjm-57	473	6	siegelbaumrh	siegelbaumrh	PROPN
bptjm-57	473	7	,	,	PUNCT
bptjm-57	473	8	et	et	PROPN
bptjm-57	473	9	al	al	PROPN
bptjm-57	473	10	.	.	PROPN
bptjm-57	473	11	robust	robust	ADJ
bptjm-57	473	12	antitumor	antitumor	PROPN
bptjm-57	473	13	responses	response	NOUN
bptjm-57	473	14	result	result	VERB
bptjm-57	473	15	from	from	ADP
bptjm-57	473	16	local	local	ADJ
bptjm-57	473	17	chemotherapy	chemotherapy	NOUN
bptjm-57	473	18	and	and	CCONJ
bptjm-57	473	19	ctla-4	ctla-4	NOUN
bptjm-57	473	20	blockade	blockade	NOUN
bptjm-57	473	21	.	.	PUNCT
bptjm-57	474	1	cancer	cancer	NOUN
bptjm-57	474	2	immunol	immunol	NOUN
bptjm-57	474	3	res	re	NOUN
bptjm-57	474	4	.	.	PUNCT
bptjm-57	475	1	2018;6(2):189	2018;6(2):189	NUM
bptjm-57	475	2	-	-	PUNCT
bptjm-57	475	3	200	200	NUM
bptjm-57	475	4	.	.	PUNCT
bptjm-57	476	1	doi:10.1158/2326	doi:10.1158/2326	NOUN
bptjm-57	476	2	-	-	PUNCT
bptjm-57	476	3	6066.cir-17	6066.cir-17	NUM
bptjm-57	476	4	-	-	PUNCT
bptjm-57	476	5	0356	0356	NUM
bptjm-57	476	6	.	.	PUNCT
bptjm-57	477	1	62	62	NUM
bptjm-57	477	2	.	.	PUNCT
bptjm-57	478	1	ctg	ctg	PROPN
bptjm-57	478	2	labs	labs	PROPN
bptjm-57	478	3	ncbi	ncbi	PROPN
bptjm-57	478	4	.	.	PUNCT
bptjm-57	479	1	clinicaltrials.gov	clinicaltrials.gov	X
bptjm-57	479	2	.	.	NOUN
bptjm-57	479	3	accessed	access	VERB
bptjm-57	479	4	august	august	PROPN
bptjm-57	479	5	9	9	NUM
bptjm-57	479	6	,	,	PUNCT
bptjm-57	479	7	2023	2023	NUM
bptjm-57	479	8	.	.	PUNCT
bptjm-57	480	1	https://clinicaltrials.gov/study/nct033812	https://clinicaltrials.gov/study/nct033812	PROPN
bptjm-57	480	2	74?term	74?term	NUM
bptjm-57	480	3	=	=	SYM
bptjm-57	480	4	combination%20therapy&cond	combination%20therapy&cond	NOUN
bptjm-57	480	5	=	=	NOUN
bptjm-57	480	6	c	c	PROPN
bptjm-57	480	7	anc	anc	PROPN
bptjm-57	480	8	er&aggfilters	er&aggfilter	NOUN
bptjm-57	480	9	=	=	NOUN
bptjm-57	480	10	results	result	NOUN
bptjm-57	480	11	:	:	PUNCT
bptjm-57	480	12	with&start=2018	with&start=2018	X
bptjm-57	480	13	-	-	PUNCT
bptjm-57	480	14	0101_&rank=4&tab	0101_&rank=4&tab	NOUN
bptjm-57	480	15	=	=	NOUN
bptjm-57	480	16	results	result	NOUN
bptjm-57	480	17	.	.	PUNCT
bptjm-57	481	1	63	63	NUM
bptjm-57	481	2	.	.	PUNCT
bptjm-57	482	1	kamakura	kamakura	PROPN
bptjm-57	482	2	d	d	PROPN
bptjm-57	482	3	,	,	PUNCT
bptjm-57	482	4	asano	asano	PROPN
bptjm-57	482	5	r	r	PROPN
bptjm-57	482	6	,	,	PUNCT
bptjm-57	482	7	yasunaga	yasunaga	NOUN
bptjm-57	482	8	m.	m.	NOUN
bptjm-57	482	9	t	t	PROPN
bptjm-57	482	10	cell	cell	NOUN
bptjm-57	482	11	bispeci	bispeci	PROPN
bptjm-57	482	12	�	�	PROPN
bptjm-57	482	13	c	c	PROPN
bptjm-57	482	14	antibodies	antibodie	VERB
bptjm-57	482	15	:	:	PUNCT
bptjm-57	482	16	an	an	DET
bptjm-57	482	17	antibody	antibody	NOUN
bptjm-57	482	18	-	-	PUNCT
bptjm-57	482	19	based	base	VERB
bptjm-57	482	20	delivery	delivery	NOUN
bptjm-57	482	21	system	system	NOUN
bptjm-57	482	22	for	for	ADP
bptjm-57	482	23	inducing	induce	VERB
bptjm-57	482	24	antitumor	antitumor	PROPN
bptjm-57	482	25	immunity	immunity	NOUN
bptjm-57	482	26	.	.	PUNCT
bptjm-57	483	1	pharmaceuticals	pharmaceutical	NOUN
bptjm-57	483	2	(	(	PUNCT
bptjm-57	483	3	basel	basel	PROPN
bptjm-57	483	4	)	)	PUNCT
bptjm-57	483	5	.	.	PUNCT
bptjm-57	484	1	2021;14(11):1172	2021;14(11):1172	X
bptjm-57	484	2	.	.	PUNCT
bptjm-57	484	3	doi:10.3390	doi:10.3390	NOUN
bptjm-57	484	4	/	/	SYM
bptjm-57	484	5	ph14111172	ph14111172	NOUN
bptjm-57	484	6	.	.	PUNCT
bptjm-57	485	1	64	64	NUM
bptjm-57	485	2	.	.	PUNCT
bptjm-57	486	1	thieblemont	thieblemont	NOUN
bptjm-57	486	2	c	c	X
bptjm-57	486	3	,	,	PUNCT
bptjm-57	486	4	phillips	phillips	PROPN
bptjm-57	486	5	t	t	PROPN
bptjm-57	486	6	,	,	PUNCT
bptjm-57	486	7	ghesquieres	ghesquiere	NOUN
bptjm-57	486	8	h	h	NOUN
bptjm-57	486	9	,	,	PUNCT
bptjm-57	486	10	et	et	PROPN
bptjm-57	486	11	al	al	PROPN
bptjm-57	486	12	.	.	PROPN
bptjm-57	486	13	epcoritamab	epcoritamab	PROPN
bptjm-57	486	14	,	,	PUNCT
bptjm-57	486	15	a	a	DET
bptjm-57	486	16	novel	novel	NOUN
bptjm-57	486	17	,	,	PUNCT
bptjm-57	486	18	subcutaneous	subcutaneous	ADJ
bptjm-57	486	19	cd3xcd20	cd3xcd20	PROPN
bptjm-57	486	20	bispeci	bispeci	PROPN
bptjm-57	486	21	�	�	PROPN
bptjm-57	486	22	c	c	PROPN
bptjm-57	486	23	t	t	PROPN
bptjm-57	486	24	-	-	PUNCT
bptjm-57	486	25	cell	cell	NOUN
bptjm-57	486	26	–	–	PUNCT
bptjm-57	486	27	engaging	engage	VERB
bptjm-57	486	28	antibody	antibody	NOUN
bptjm-57	486	29	,	,	PUNCT
bptjm-57	486	30	in	in	ADP
bptjm-57	486	31	relapsed	relapse	VERB
bptjm-57	486	32	or	or	CCONJ
bptjm-57	486	33	refractory	refractory	NOUN
bptjm-57	486	34	large	large	ADJ
bptjm-57	486	35	b	b	NOUN
bptjm-57	486	36	-	-	PUNCT
bptjm-57	486	37	cell	cell	NOUN
bptjm-57	486	38	lymphoma	lymphoma	NOUN
bptjm-57	486	39	:	:	PUNCT
bptjm-57	486	40	dose	dose	NOUN
bptjm-57	486	41	expansion	expansion	NOUN
bptjm-57	486	42	in	in	ADP
bptjm-57	486	43	a	a	DET
bptjm-57	486	44	phase	phase	NOUN
bptjm-57	486	45	i	i	PRON
bptjm-57	486	46	/	/	SYM
bptjm-57	486	47	ii	ii	PROPN
bptjm-57	486	48	trial	trial	NOUN
bptjm-57	486	49	.	.	PUNCT
bptjm-57	487	1	journal	journal	NOUN
bptjm-57	487	2	of	of	ADP
bptjm-57	487	3	clinical	clinical	ADJ
bptjm-57	487	4	oncology	oncology	NOUN
bptjm-57	487	5	.	.	PUNCT
bptjm-57	488	1	2023;41(12):2238	2023;41(12):2238	NUM
bptjm-57	488	2	.	.	X
bptjm-57	489	1	doi:10.1200	doi:10.1200	NOUN
bptjm-57	489	2	/	/	SYM
bptjm-57	489	3	jco.22.01725	jco.22.01725	PROPN
bptjm-57	489	4	.	.	PUNCT
bptjm-57	490	1	65	65	NUM
bptjm-57	490	2	.	.	PUNCT
bptjm-57	490	3	oda	oda	PROPN
bptjm-57	491	1	y	y	PROPN
bptjm-57	491	2	,	,	PUNCT
bptjm-57	491	3	narukawam	narukawam	PROPN
bptjm-57	491	4	.	.	PUNCT
bptjm-57	492	1	response	response	NOUN
bptjm-57	492	2	rate	rate	NOUN
bptjm-57	492	3	of	of	ADP
bptjm-57	492	4	anticancer	anticancer	NOUN
bptjm-57	492	5	drugs	drug	NOUN
bptjm-57	492	6	approved	approve	VERB
bptjm-57	492	7	by	by	ADP
bptjm-57	492	8	the	the	DET
bptjm-57	492	9	food	food	NOUN
bptjm-57	492	10	and	and	CCONJ
bptjm-57	492	11	drug	drug	NOUN
bptjm-57	492	12	administration	administration	NOUN
bptjm-57	492	13	based	base	VERB
bptjm-57	492	14	on	on	ADP
bptjm-57	492	15	a	a	DET
bptjm-57	492	16	single	single	ADJ
bptjm-57	492	17	-	-	PUNCT
bptjm-57	492	18	arm	arm	NOUN
bptjm-57	492	19	trial	trial	NOUN
bptjm-57	492	20	.	.	PUNCT
bptjm-57	493	1	bmc	bmc	NOUN
bptjm-57	493	2	cancer	cancer	NOUN
bptjm-57	493	3	.	.	PUNCT
bptjm-57	494	1	2022;22(1):277	2022;22(1):277	NOUN
bptjm-57	494	2	.	.	PUNCT
bptjm-57	495	1	doi:10.1186	doi:10.1186	PROPN
bptjm-57	495	2	/	/	SYM
bptjm-57	495	3	s12885	s12885	NOUN
bptjm-57	495	4	-	-	PUNCT
bptjm-57	495	5	022	022	NUM
bptjm-57	495	6	-	-	PUNCT
bptjm-57	495	7	09383	09383	NUM
bptjm-57	495	8	-	-	PUNCT
bptjm-57	495	9	w.	w.	PROPN
bptjm-57	495	10	66	66	NUM
bptjm-57	495	11	.	.	PUNCT
bptjm-57	496	1	d’souza	d’souza	NOUN
bptjm-57	496	2	a	a	PRON
bptjm-57	496	3	,	,	PUNCT
bptjm-57	496	4	shah	shah	PROPN
bptjm-57	496	5	n	n	CCONJ
bptjm-57	496	6	,	,	PUNCT
bptjm-57	496	7	rodriguez	rodriguez	PROPN
bptjm-57	496	8	c	c	PROPN
bptjm-57	496	9	,	,	PUNCT
bptjm-57	496	10	et	et	PROPN
bptjm-57	496	11	al	al	PROPN
bptjm-57	496	12	.	.	PUNCT
bptjm-57	497	1	a	a	DET
bptjm-57	497	2	phase	phase	NOUN
bptjm-57	497	3	i	i	PRON
bptjm-57	497	4	first	first	ADJ
bptjm-57	497	5	-	-	PUNCT
bptjm-57	497	6	in	in	ADP
bptjm-57	497	7	-	-	PUNCT
bptjm-57	497	8	human	human	ADJ
bptjm-57	497	9	study	study	NOUN
bptjm-57	497	10	of	of	ADP
bptjm-57	497	11	abbv-383	abbv-383	NOUN
bptjm-57	497	12	,	,	PUNCT
bptjm-57	497	13	a	a	DET
bptjm-57	497	14	b	b	NOUN
bptjm-57	497	15	-	-	PUNCT
bptjm-57	497	16	cell	cell	NOUN
bptjm-57	497	17	maturation	maturation	NOUN
bptjm-57	497	18	antigen	antigen	ADP
bptjm-57	497	19	×	×	PROPN
bptjm-57	497	20	cd3	cd3	PROPN
bptjm-57	497	21	bispeci	bispeci	PROPN
bptjm-57	497	22	�	�	PROPN
bptjm-57	497	23	c	c	PROPN
bptjm-57	497	24	t	t	PROPN
bptjm-57	497	25	-	-	PUNCT
bptjm-57	497	26	cell	cell	NOUN
bptjm-57	497	27	redirecting	redirect	VERB
bptjm-57	497	28	antibody	antibody	NOUN
bptjm-57	497	29	,	,	PUNCT
bptjm-57	497	30	in	in	ADP
bptjm-57	497	31	patients	patient	NOUN
bptjm-57	497	32	with	with	ADP
bptjm-57	497	33	relapsed	relapse	VERB
bptjm-57	497	34	/	/	SYM
bptjm-57	497	35	refractory	refractory	NOUN
bptjm-57	497	36	multiple	multiple	ADJ
bptjm-57	497	37	myeloma	myeloma	NOUN
bptjm-57	497	38	.	.	PUNCT
bptjm-57	498	1	j	j	PROPN
bptjm-57	498	2	clin	clin	PROPN
bptjm-57	498	3	oncol	oncol	PROPN
bptjm-57	498	4	.	.	PUNCT
bptjm-57	499	1	2022;40(31):3576	2022;40(31):3576	NUM
bptjm-57	499	2	-	-	SYM
bptjm-57	499	3	3586	3586	NUM
bptjm-57	499	4	.	.	PUNCT
bptjm-57	500	1	berkeley	berkeley	PROPN
bptjm-57	500	2	pharma	pharma	PROPN
bptjm-57	500	3	tech	tech	PROPN
bptjm-57	500	4	journal	journal	NOUN
bptjm-57	500	5	of	of	ADP
bptjm-57	500	6	medicine	medicine	NOUN
bptjm-57	500	7	|	|	ADV
bptjm-57	500	8	111	111	NUM
bptjm-57	500	9	http://clinicaltrials.gov/	http://clinicaltrials.gov/	NOUN
bptjm-57	500	10	https://clinicaltrials.gov/study/nct03873805	https://clinicaltrials.gov/study/nct03873805	PROPN
bptjm-57	500	11	https://clinicaltrials.gov/study/nct03873805	https://clinicaltrials.gov/study/nct03873805	PROPN
bptjm-57	500	12	http://clinicaltrials.gov/	http://clinicaltrials.gov/	VERB
bptjm-57	500	13	http://clinicaltrials.gov/	http://clinicaltrials.gov/	NOUN
bptjm-57	500	14	doi:10.1200	doi:10.1200	PRON
bptjm-57	500	15	/	/	SYM
bptjm-57	501	1	jco.22.01504	jco.22.01504	PROPN
bptjm-57	501	2	67	67	NUM
bptjm-57	501	3	.	.	PUNCT
bptjm-57	502	1	park	park	PROPN
bptjm-57	502	2	ja	ja	PROPN
bptjm-57	502	3	,	,	PUNCT
bptjm-57	502	4	cheung	cheung	PROPN
bptjm-57	502	5	nkv	nkv	PROPN
bptjm-57	502	6	.	.	PUNCT
bptjm-57	503	1	overcoming	overcome	VERB
bptjm-57	503	2	tumor	tumor	NOUN
bptjm-57	503	3	heterogeneity	heterogeneity	NOUN
bptjm-57	503	4	by	by	ADP
bptjm-57	503	5	ex	ex	PRON
bptjm-57	503	6	vivo	vivo	NOUN
bptjm-57	503	7	arming	arming	NOUN
bptjm-57	503	8	of	of	ADP
bptjm-57	503	9	t	t	NOUN
bptjm-57	503	10	cells	cell	NOUN
bptjm-57	503	11	using	use	VERB
bptjm-57	503	12	multiple	multiple	ADJ
bptjm-57	503	13	bispeci	bispeci	PROPN
bptjm-57	503	14	�	�	PROPN
bptjm-57	503	15	c	c	PROPN
bptjm-57	503	16	antibodies	antibodie	VERB
bptjm-57	503	17	.	.	PUNCT
bptjm-57	504	1	j	j	PROPN
bptjm-57	504	2	immunother	immunother	ADJ
bptjm-57	504	3	cancer	cancer	NOUN
bptjm-57	504	4	.	.	PUNCT
bptjm-57	505	1	2022;10(1):e003771	2022;10(1):e003771	X
bptjm-57	505	2	.	.	PUNCT
bptjm-57	505	3	doi:10.1136	doi:10.1136	NOUN
bptjm-57	505	4	/	/	SYM
bptjm-57	505	5	jitc-2021	jitc-2021	NOUN
bptjm-57	505	6	-	-	PUNCT
bptjm-57	505	7	003771	003771	NUM
bptjm-57	505	8	.	.	PUNCT
bptjm-57	506	1	68	68	NUM
bptjm-57	506	2	.	.	PUNCT
bptjm-57	506	3	patra	patra	PROPN
bptjm-57	506	4	jk	jk	PROPN
bptjm-57	506	5	,	,	PUNCT
bptjm-57	506	6	das	das	PROPN
bptjm-57	506	7	g	g	PROPN
bptjm-57	506	8	,	,	PUNCT
bptjm-57	506	9	fraceto	fraceto	PROPN
bptjm-57	506	10	lf	lf	PROPN
bptjm-57	506	11	,	,	PUNCT
bptjm-57	506	12	et	et	PROPN
bptjm-57	506	13	al	al	PROPN
bptjm-57	506	14	.	.	PUNCT
bptjm-57	507	1	nano	nano	PROPN
bptjm-57	507	2	based	base	VERB
bptjm-57	507	3	drug	drug	NOUN
bptjm-57	507	4	delivery	delivery	NOUN
bptjm-57	507	5	systems	system	NOUN
bptjm-57	507	6	:	:	PUNCT
bptjm-57	507	7	recent	recent	ADJ
bptjm-57	507	8	developments	development	NOUN
bptjm-57	507	9	and	and	CCONJ
bptjm-57	507	10	future	future	ADJ
bptjm-57	507	11	prospects	prospect	NOUN
bptjm-57	507	12	.	.	PUNCT
bptjm-57	508	1	j	j	PROPN
bptjm-57	508	2	nanobiotechnology	nanobiotechnology	NOUN
bptjm-57	508	3	.	.	PUNCT
bptjm-57	509	1	2018;16(1):71	2018;16(1):71	NUM
bptjm-57	509	2	.	.	PUNCT
bptjm-57	510	1	doi:10.1186	doi:10.1186	PROPN
bptjm-57	510	2	/	/	SYM
bptjm-57	510	3	s12951	s12951	PROPN
bptjm-57	510	4	-	-	PUNCT
bptjm-57	510	5	018	018	NUM
bptjm-57	510	6	-	-	PUNCT
bptjm-57	510	7	0392	0392	NUM
bptjm-57	510	8	-	-	SYM
bptjm-57	510	9	8	8	NUM
bptjm-57	510	10	.	.	NUM
bptjm-57	510	11	69	69	NUM
bptjm-57	510	12	.	.	PUNCT
bptjm-57	511	1	liu	liu	PROPN
bptjm-57	511	2	q	q	PROPN
bptjm-57	511	3	,	,	PUNCT
bptjm-57	511	4	cai	cai	PROPN
bptjm-57	511	5	j	j	PROPN
bptjm-57	511	6	,	,	PUNCT
bptjm-57	511	7	zheng	zheng	PROPN
bptjm-57	511	8	y	y	PROPN
bptjm-57	511	9	,	,	PUNCT
bptjm-57	511	10	et	et	PROPN
bptjm-57	511	11	al	al	PROPN
bptjm-57	511	12	.	.	PUNCT
bptjm-57	511	13	nanornp	nanornp	PROPN
bptjm-57	511	14	overcomes	overcome	VERB
bptjm-57	511	15	tumor	tumor	NOUN
bptjm-57	511	16	heterogeneity	heterogeneity	NOUN
bptjm-57	511	17	in	in	ADP
bptjm-57	511	18	cancer	cancer	NOUN
bptjm-57	511	19	treatment.nano	treatment.nano	PROPN
bptjm-57	511	20	lett	lett	PROPN
bptjm-57	511	21	.	.	PUNCT
bptjm-57	512	1	2019;19(11):7662	2019;19(11):7662	NUM
bptjm-57	512	2	-	-	SYM
bptjm-57	512	3	7672	7672	NUM
bptjm-57	512	4	.	.	PUNCT
bptjm-57	513	1	doi:10.1021	doi:10.1021	ADJ
bptjm-57	513	2	/	/	SYM
bptjm-57	513	3	acs.nanolett.9b02501	acs.nanolett.9b02501	ADJ
bptjm-57	513	4	.	.	PUNCT
bptjm-57	514	1	70	70	NUM
bptjm-57	514	2	.	.	PUNCT
bptjm-57	515	1	praharaj	praharaj	VERB
bptjm-57	515	2	pp	pp	PROPN
bptjm-57	515	3	,	,	PUNCT
bptjm-57	515	4	bhutia	bhutia	PROPN
bptjm-57	515	5	sk	sk	PROPN
bptjm-57	515	6	,	,	PUNCT
bptjm-57	515	7	nagrath	nagrath	NOUN
bptjm-57	515	8	s	s	PART
bptjm-57	515	9	,	,	PUNCT
bptjm-57	515	10	bitting	bit	VERB
bptjm-57	515	11	rl	rl	ADP
bptjm-57	515	12	,	,	PUNCT
bptjm-57	515	13	deep	deep	ADJ
bptjm-57	515	14	g.	g.	PROPN
bptjm-57	515	15	circulating	circulate	VERB
bptjm-57	515	16	tumor	tumor	NOUN
bptjm-57	515	17	cell	cell	NOUN
bptjm-57	515	18	-	-	PUNCT
bptjm-57	515	19	derived	derive	VERB
bptjm-57	515	20	organoids	organoid	NOUN
bptjm-57	515	21	:	:	PUNCT
bptjm-57	515	22	current	current	ADJ
bptjm-57	515	23	challenges	challenge	NOUN
bptjm-57	515	24	and	and	CCONJ
bptjm-57	515	25	promises	promise	NOUN
bptjm-57	515	26	in	in	ADP
bptjm-57	515	27	medical	medical	ADJ
bptjm-57	515	28	research	research	NOUN
bptjm-57	515	29	and	and	CCONJ
bptjm-57	515	30	precision	precision	NOUN
bptjm-57	515	31	medicine	medicine	NOUN
bptjm-57	515	32	.	.	PUNCT
bptjm-57	516	1	biochim	biochim	PROPN
bptjm-57	516	2	biophys	biophys	PROPN
bptjm-57	516	3	acta	acta	PROPN
bptjm-57	516	4	rev	rev	PROPN
bptjm-57	516	5	cancer	cancer	NOUN
bptjm-57	516	6	.	.	PUNCT
bptjm-57	517	1	2018;1869(2):117	2018;1869(2):117	NUM
bptjm-57	517	2	-	-	PUNCT
bptjm-57	517	3	127	127	NUM
bptjm-57	517	4	.	.	PUNCT
bptjm-57	518	1	doi:10.1016	doi:10.1016	PROPN
bptjm-57	518	2	/	/	SYM
bptjm-57	518	3	j.bbcan.2017.12.005	j.bbcan.2017.12.005	PROPN
bptjm-57	518	4	.	.	PUNCT
bptjm-57	519	1	71	71	NUM
bptjm-57	519	2	.	.	PUNCT
bptjm-57	520	1	liquid	liquid	ADJ
bptjm-57	520	2	biopsy	biopsy	NOUN
bptjm-57	520	3	:	:	PUNCT
bptjm-57	520	4	what	what	PRON
bptjm-57	520	5	it	it	PRON
bptjm-57	520	6	is	be	AUX
bptjm-57	520	7	&	&	CCONJ
bptjm-57	520	8	procedure	procedure	NOUN
bptjm-57	520	9	details	detail	NOUN
bptjm-57	520	10	.	.	PUNCT
bptjm-57	521	1	cleveland	cleveland	PROPN
bptjm-57	521	2	clinic	clinic	PROPN
bptjm-57	521	3	.	.	PUNCT
bptjm-57	522	1	https://my.clevelandclinic.org/health/diagnostics/	https://my.clevelandclinic.org/health/diagnostics/	PROPN
bptjm-57	522	2	23992	23992	NUM
bptjm-57	522	3	-	-	PUNCT
bptjm-57	522	4	liquid	liquid	NOUN
bptjm-57	522	5	-	-	PUNCT
bptjm-57	522	6	biopsy	biopsy	NOUN
bptjm-57	522	7	72	72	NUM
bptjm-57	522	8	.	.	PUNCT
bptjm-57	523	1	lin	lin	PROPN
bptjm-57	523	2	d	d	PROPN
bptjm-57	523	3	,	,	PUNCT
bptjm-57	523	4	shen	shen	PROPN
bptjm-57	523	5	l	l	NOUN
bptjm-57	523	6	,	,	PUNCT
bptjm-57	523	7	luom	luom	NOUN
bptjm-57	523	8	,	,	PUNCT
bptjm-57	523	9	et	et	PROPN
bptjm-57	523	10	al	al	PROPN
bptjm-57	523	11	.	.	PROPN
bptjm-57	523	12	circulating	circulate	VERB
bptjm-57	523	13	tumor	tumor	NOUN
bptjm-57	523	14	cells	cell	NOUN
bptjm-57	523	15	:	:	PUNCT
bptjm-57	523	16	biology	biology	NOUN
bptjm-57	523	17	and	and	CCONJ
bptjm-57	523	18	clinical	clinical	ADJ
bptjm-57	523	19	signi	signi	PROPN
bptjm-57	523	20	�	�	PROPN
bptjm-57	523	21	cance	cance	PROPN
bptjm-57	523	22	.	.	PUNCT
bptjm-57	524	1	signal	signal	PROPN
bptjm-57	524	2	transduct	transduct	NOUN
bptjm-57	524	3	target	target	NOUN
bptjm-57	524	4	ther	ther	ADV
bptjm-57	524	5	.	.	PUNCT
bptjm-57	525	1	2021;6(1):404	2021;6(1):404	X
bptjm-57	525	2	.	.	PUNCT
bptjm-57	525	3	doi:10.1038	doi:10.1038	NOUN
bptjm-57	525	4	/	/	SYM
bptjm-57	525	5	s41392	s41392	VERB
bptjm-57	525	6	-	-	PUNCT
bptjm-57	525	7	021	021	NUM
bptjm-57	525	8	-	-	PUNCT
bptjm-57	525	9	00817	00817	NUM
bptjm-57	525	10	-	-	SYM
bptjm-57	525	11	8	8	NUM
bptjm-57	525	12	.	.	X
bptjm-57	526	1	73	73	NUM
bptjm-57	526	2	.	.	PUNCT
bptjm-57	527	1	qiao	qiao	PROPN
bptjm-57	527	2	y	y	PROPN
bptjm-57	527	3	,	,	PUNCT
bptjm-57	527	4	li	li	PROPN
bptjm-57	527	5	j	j	PROPN
bptjm-57	527	6	,	,	PUNCT
bptjm-57	527	7	shi	shi	PROPN
bptjm-57	527	8	c	c	PROPN
bptjm-57	527	9	,	,	PUNCT
bptjm-57	527	10	et	et	PROPN
bptjm-57	527	11	al	al	PROPN
bptjm-57	527	12	.	.	PROPN
bptjm-57	528	1	prognostic	prognostic	ADJ
bptjm-57	528	2	value	value	NOUN
bptjm-57	528	3	of	of	ADP
bptjm-57	528	4	circulating	circulate	VERB
bptjm-57	528	5	tumor	tumor	NOUN
bptjm-57	528	6	cells	cell	NOUN
bptjm-57	528	7	in	in	ADP
bptjm-57	528	8	the	the	DET
bptjm-57	528	9	peripheral	peripheral	ADJ
bptjm-57	528	10	blood	blood	NOUN
bptjm-57	528	11	of	of	ADP
bptjm-57	528	12	patients	patient	NOUN
bptjm-57	528	13	with	with	ADP
bptjm-57	528	14	esophageal	esophageal	ADJ
bptjm-57	528	15	squamous	squamous	ADJ
bptjm-57	528	16	cell	cell	NOUN
bptjm-57	528	17	carcinoma	carcinoma	NOUN
bptjm-57	528	18	.	.	PUNCT
bptjm-57	529	1	onco	onco	NOUN
bptjm-57	529	2	targets	target	NOUN
bptjm-57	529	3	ther	ther	ADV
bptjm-57	529	4	.	.	PUNCT
bptjm-57	530	1	2017;10:1363	2017;10:1363	NUM
bptjm-57	530	2	-	-	SYM
bptjm-57	530	3	1373	1373	NUM
bptjm-57	530	4	.	.	PUNCT
bptjm-57	530	5	doi:10.2147	doi:10.2147	NOUN
bptjm-57	530	6	/	/	SYM
bptjm-57	530	7	ott.s129004	ott.s129004	NOUN
bptjm-57	530	8	.	.	PUNCT
bptjm-57	531	1	74	74	NUM
bptjm-57	531	2	.	.	PUNCT
bptjm-57	532	1	zhou	zhou	PROPN
bptjm-57	532	2	y	y	PROPN
bptjm-57	532	3	,	,	PUNCT
bptjm-57	532	4	yang	yang	PROPN
bptjm-57	532	5	d	d	PROPN
bptjm-57	532	6	,	,	PUNCT
bptjm-57	532	7	yang	yang	PROPN
bptjm-57	532	8	q	q	PROPN
bptjm-57	532	9	,	,	PUNCT
bptjm-57	532	10	et	et	PROPN
bptjm-57	532	11	al	al	PROPN
bptjm-57	532	12	.	.	PUNCT
bptjm-57	532	13	single	single	ADJ
bptjm-57	532	14	-	-	PUNCT
bptjm-57	532	15	cell	cell	NOUN
bptjm-57	532	16	rna	rna	NOUN
bptjm-57	532	17	landscape	landscape	NOUN
bptjm-57	532	18	of	of	ADP
bptjm-57	532	19	intratumoral	intratumoral	ADJ
bptjm-57	532	20	heterogeneity	heterogeneity	NOUN
bptjm-57	532	21	and	and	CCONJ
bptjm-57	532	22	immunosuppressive	immunosuppressive	ADJ
bptjm-57	532	23	microenvironment	microenvironment	NOUN
bptjm-57	532	24	in	in	ADP
bptjm-57	532	25	advanced	advanced	ADJ
bptjm-57	532	26	osteosarcoma	osteosarcoma	NOUN
bptjm-57	532	27	[	[	X
bptjm-57	532	28	published	publish	VERB
bptjm-57	532	29	correction	correction	NOUN
bptjm-57	532	30	appears	appear	VERB
bptjm-57	532	31	in	in	ADP
bptjm-57	532	32	nat	nat	PROPN
bptjm-57	532	33	commun	commun	PROPN
bptjm-57	532	34	.	.	PUNCT
bptjm-57	533	1	2021	2021	NUM
bptjm-57	533	2	apr	apr	PROPN
bptjm-57	533	3	30;12(1):2567].nat	30;12(1):2567].nat	NUM
bptjm-57	533	4	commun	commun	NOUN
bptjm-57	533	5	.	.	PUNCT
bptjm-57	534	1	2020;11(1):6322	2020;11(1):6322	NUM
bptjm-57	534	2	.	.	PUNCT
bptjm-57	534	3	doi:10.1038	doi:10.1038	PROPN
bptjm-57	534	4	/	/	SYM
bptjm-57	534	5	s41467	s41467	NOUN
bptjm-57	534	6	-	-	PUNCT
bptjm-57	534	7	020	020	NUM
bptjm-57	534	8	-	-	PUNCT
bptjm-57	534	9	20059	20059	NUM
bptjm-57	534	10	-	-	SYM
bptjm-57	534	11	6	6	NUM
bptjm-57	534	12	.	.	X
bptjm-57	535	1	75	75	NUM
bptjm-57	535	2	.	.	PUNCT
bptjm-57	536	1	schwarz	schwarz	PROPN
bptjm-57	536	2	rf	rf	PROPN
bptjm-57	536	3	,	,	PUNCT
bptjm-57	536	4	ng	ng	PROPN
bptjm-57	536	5	ck	ck	PROPN
bptjm-57	536	6	,	,	PUNCT
bptjm-57	536	7	cooke	cooke	PROPN
bptjm-57	536	8	sl	sl	PROPN
bptjm-57	536	9	,	,	PUNCT
bptjm-57	536	10	et	et	PROPN
bptjm-57	536	11	al	al	PROPN
bptjm-57	536	12	.	.	PROPN
bptjm-57	537	1	spatial	spatial	ADJ
bptjm-57	537	2	and	and	CCONJ
bptjm-57	537	3	temporal	temporal	ADJ
bptjm-57	537	4	heterogeneity	heterogeneity	NOUN
bptjm-57	537	5	in	in	ADP
bptjm-57	537	6	high	high	ADJ
bptjm-57	537	7	-	-	PUNCT
bptjm-57	537	8	grade	grade	NOUN
bptjm-57	537	9	serous	serous	ADJ
bptjm-57	537	10	ovarian	ovarian	ADJ
bptjm-57	537	11	cancer	cancer	NOUN
bptjm-57	537	12	:	:	PUNCT
bptjm-57	537	13	a	a	DET
bptjm-57	537	14	phylogenetic	phylogenetic	ADJ
bptjm-57	537	15	analysis	analysis	NOUN
bptjm-57	537	16	.	.	PUNCT
bptjm-57	538	1	plosmed	plosme	VERB
bptjm-57	538	2	.	.	PUNCT
bptjm-57	539	1	2015;12(2):e1001789	2015;12(2):e1001789	X
bptjm-57	539	2	.	.	PUNCT
bptjm-57	540	1	doi:10.1371	doi:10.1371	NOUN
bptjm-57	540	2	/	/	SYM
bptjm-57	541	1	journal.pmed.1001789	journal.pmed.1001789	ADV
bptjm-57	541	2	.	.	PUNCT
bptjm-57	541	3	berkeley	berkeley	PROPN
bptjm-57	541	4	pharma	pharma	PROPN
bptjm-57	541	5	tech	tech	PROPN
bptjm-57	541	6	journal	journal	NOUN
bptjm-57	541	7	of	of	ADP
bptjm-57	541	8	medicine	medicine	NOUN
bptjm-57	541	9	|	|	ADV
bptjm-57	541	10	112	112	NUM
bptjm-57	541	11	https://my.clevelandclinic.org/health/diagnostics/23992-liquid-biopsy	https://my.clevelandclinic.org/health/diagnostics/23992-liquid-biopsy	ADJ
bptjm-57	541	12	https://my.clevelandclinic.org/health/diagnostics/23992-liquid-biopsy	https://my.clevelandclinic.org/health/diagnostics/23992-liquid-biopsy	NOUN