id	sid	tid	token	lemma	pos
bptjm-64	1	1	berkeley	berkeley	PROPN
bptjm-64	1	2	pharma	pharma	PROPN
bptjm-64	1	3	tech	tech	NOUN
bptjm-64	1	4	journal	journal	NOUN
bptjm-64	1	5	of	of	ADP
bptjm-64	1	6	medicine	medicine	NOUN
bptjm-64	1	7	correspondence	correspondence	NOUN
bptjm-64	1	8	:	:	PUNCT
bptjm-64	1	9	sanchithabpt1@gmail.com	sanchithabpt1@gmail.com	X
bptjm-64	1	10	keywords	keyword	NOUN
bptjm-64	1	11	:	:	PUNCT
bptjm-64	1	12	tumor	tumor	NOUN
bptjm-64	1	13	microenvironment	microenvironment	ADJ
bptjm-64	1	14	immunotherapy	immunotherapy	NOUN
bptjm-64	1	15	cytotoxic	cytotoxic	PROPN
bptjm-64	1	16	t	t	PROPN
bptjm-64	1	17	lymphocytes	lymphocyte	VERB
bptjm-64	1	18	pd-1	pd-1	ADV
bptjm-64	1	19	ctla-4	ctla-4	NOUN
bptjm-64	1	20	lactic	lactic	ADJ
bptjm-64	1	21	acid	acid	NOUN
bptjm-64	1	22	non	non	ADJ
bptjm-64	1	23	-	-	ADJ
bptjm-64	1	24	small	small	ADJ
bptjm-64	1	25	cell	cell	NOUN
bptjm-64	1	26	lung	lung	NOUN
bptjm-64	1	27	cancer	cancer	NOUN
bptjm-64	1	28	(	(	PUNCT
bptjm-64	1	29	nsclc	nsclc	NOUN
bptjm-64	1	30	)	)	PUNCT
bptjm-64	1	31	submitted	submit	VERB
bptjm-64	1	32	august	august	PROPN
bptjm-64	1	33	11	11	NUM
bptjm-64	1	34	,	,	PUNCT
bptjm-64	1	35	2023	2023	NUM
bptjm-64	1	36	accepted	accept	VERB
bptjm-64	1	37	may	may	PROPN
bptjm-64	1	38	23	23	NUM
bptjm-64	1	39	,	,	PUNCT
bptjm-64	1	40	2024	2024	NUM
bptjm-64	1	41	published	publish	VERB
bptjm-64	1	42	june	june	PROPN
bptjm-64	1	43	28	28	NUM
bptjm-64	1	44	,	,	PUNCT
bptjm-64	1	45	2024	2024	NUM
bptjm-64	1	46	full	full	ADJ
bptjm-64	1	47	open	open	ADJ
bptjm-64	1	48	access	access	NOUN
bptjm-64	1	49	creative	creative	ADJ
bptjm-64	1	50	commons	common	NOUN
bptjm-64	1	51	attribution	attribution	NOUN
bptjm-64	1	52	license	license	VERB
bptjm-64	1	53	4.0	4.0	NUM
bptjm-64	1	54	abstract	abstract	NOUN
bptjm-64	1	55	the	the	DET
bptjm-64	1	56	tumor	tumor	NOUN
bptjm-64	1	57	microenvironment	microenvironment	NOUN
bptjm-64	1	58	(	(	PUNCT
bptjm-64	1	59	tme	tme	NOUN
bptjm-64	1	60	)	)	PUNCT
bptjm-64	1	61	surrounds	surround	VERB
bptjm-64	1	62	the	the	DET
bptjm-64	1	63	tumor	tumor	NOUN
bptjm-64	1	64	and	and	CCONJ
bptjm-64	1	65	includes	include	VERB
bptjm-64	1	66	blood	blood	NOUN
bptjm-64	1	67	vessels	vessel	NOUN
bptjm-64	1	68	,	,	PUNCT
bptjm-64	1	69	immune	immune	ADJ
bptjm-64	1	70	cells	cell	NOUN
bptjm-64	1	71	,	,	PUNCT
bptjm-64	1	72	fibroblasts	fibroblast	NOUN
bptjm-64	1	73	,	,	PUNCT
bptjm-64	1	74	signaling	signal	VERB
bptjm-64	1	75	molecules	molecule	NOUN
bptjm-64	1	76	,	,	PUNCT
bptjm-64	1	77	and	and	CCONJ
bptjm-64	1	78	the	the	DET
bptjm-64	1	79	extracellular	extracellular	ADJ
bptjm-64	1	80	matrix	matrix	NOUN
bptjm-64	1	81	.	.	PUNCT
bptjm-64	2	1	this	this	DET
bptjm-64	2	2	review	review	NOUN
bptjm-64	2	3	examines	examine	VERB
bptjm-64	2	4	the	the	DET
bptjm-64	2	5	cellular	cellular	ADJ
bptjm-64	2	6	components	component	NOUN
bptjm-64	2	7	and	and	CCONJ
bptjm-64	2	8	pathways	pathway	NOUN
bptjm-64	2	9	within	within	ADP
bptjm-64	2	10	the	the	DET
bptjm-64	2	11	tme	tme	NOUN
bptjm-64	2	12	,	,	PUNCT
bptjm-64	2	13	highlighting	highlight	VERB
bptjm-64	2	14	their	their	PRON
bptjm-64	2	15	potential	potential	NOUN
bptjm-64	2	16	as	as	ADP
bptjm-64	2	17	targets	target	NOUN
bptjm-64	2	18	for	for	ADP
bptjm-64	2	19	immunotherapy	immunotherapy	NOUN
bptjm-64	2	20	.	.	PUNCT
bptjm-64	3	1	it	it	PRON
bptjm-64	3	2	also	also	ADV
bptjm-64	3	3	covers	cover	VERB
bptjm-64	3	4	recent	recent	ADJ
bptjm-64	3	5	advances	advance	NOUN
bptjm-64	3	6	from	from	ADP
bptjm-64	3	7	the	the	DET
bptjm-64	3	8	past	past	ADJ
bptjm-64	3	9	several	several	ADJ
bptjm-64	3	10	years	year	NOUN
bptjm-64	3	11	in	in	ADP
bptjm-64	3	12	tme	tme	PROPN
bptjm-64	3	13	,	,	PUNCT
bptjm-64	3	14	immunotherapy	immunotherapy	NOUN
bptjm-64	3	15	,	,	PUNCT
bptjm-64	3	16	and	and	CCONJ
bptjm-64	3	17	combination	combination	NOUN
bptjm-64	3	18	therapy	therapy	NOUN
bptjm-64	3	19	.	.	PUNCT
bptjm-64	4	1	the	the	DET
bptjm-64	4	2	review	review	NOUN
bptjm-64	4	3	emphasizes	emphasize	VERB
bptjm-64	4	4	the	the	DET
bptjm-64	4	5	role	role	NOUN
bptjm-64	4	6	of	of	ADP
bptjm-64	4	7	cd8	cd8	PROPN
bptjm-64	4	8	+	+	PROPN
bptjm-64	4	9	t	t	PROPN
bptjm-64	4	10	cells	cell	NOUN
bptjm-64	4	11	in	in	ADP
bptjm-64	4	12	the	the	DET
bptjm-64	4	13	tme	tme	NOUN
bptjm-64	4	14	and	and	CCONJ
bptjm-64	4	15	their	their	PRON
bptjm-64	4	16	relevance	relevance	NOUN
bptjm-64	4	17	to	to	ADP
bptjm-64	4	18	immunotherapy	immunotherapy	NOUN
bptjm-64	4	19	.	.	PUNCT
bptjm-64	5	1	it	it	PRON
bptjm-64	5	2	discusses	discuss	VERB
bptjm-64	5	3	various	various	ADJ
bptjm-64	5	4	t	t	NOUN
bptjm-64	5	5	cell	cell	NOUN
bptjm-64	5	6	-	-	PUNCT
bptjm-64	5	7	targeted	target	VERB
bptjm-64	5	8	treatments	treatment	NOUN
bptjm-64	5	9	,	,	PUNCT
bptjm-64	5	10	including	include	VERB
bptjm-64	5	11	pd-1	pd-1	ADV
bptjm-64	5	12	/	/	SYM
bptjm-64	5	13	pdl1	pdl1	NOUN
bptjm-64	5	14	,	,	PUNCT
bptjm-64	5	15	ctla-4	ctla-4	PROPN
bptjm-64	5	16	,	,	PUNCT
bptjm-64	5	17	vegf	vegf	PROPN
bptjm-64	5	18	,	,	PUNCT
bptjm-64	5	19	interferon	interferon	PROPN
bptjm-64	5	20	-	-	PUNCT
bptjm-64	5	21	ɣ	ɣ	PROPN
bptjm-64	5	22	,	,	PUNCT
bptjm-64	5	23	lag-3	lag-3	X
bptjm-64	5	24	,	,	PUNCT
bptjm-64	5	25	and	and	CCONJ
bptjm-64	5	26	er	er	INTJ
bptjm-64	5	27	stress	stress	NOUN
bptjm-64	5	28	-	-	PUNCT
bptjm-64	5	29	xbp1	xbp1	PROPN
bptjm-64	5	30	.	.	PUNCT
bptjm-64	6	1	recognizing	recognize	VERB
bptjm-64	6	2	the	the	DET
bptjm-64	6	3	complexity	complexity	NOUN
bptjm-64	6	4	and	and	CCONJ
bptjm-64	6	5	uniqueness	uniqueness	NOUN
bptjm-64	6	6	of	of	ADP
bptjm-64	6	7	each	each	DET
bptjm-64	6	8	tumor	tumor	NOUN
bptjm-64	6	9	's	's	PART
bptjm-64	6	10	immunotherapy	immunotherapy	NOUN
bptjm-64	6	11	network	network	NOUN
bptjm-64	6	12	,	,	PUNCT
bptjm-64	6	13	the	the	DET
bptjm-64	6	14	review	review	NOUN
bptjm-64	6	15	aims	aim	VERB
bptjm-64	6	16	to	to	PART
bptjm-64	6	17	understand	understand	VERB
bptjm-64	6	18	and	and	CCONJ
bptjm-64	6	19	compare	compare	VERB
bptjm-64	6	20	the	the	DET
bptjm-64	6	21	tmes	tme	NOUN
bptjm-64	6	22	of	of	ADP
bptjm-64	6	23	different	different	ADJ
bptjm-64	6	24	cancers	cancer	NOUN
bptjm-64	6	25	and	and	CCONJ
bptjm-64	6	26	the	the	DET
bptjm-64	6	27	respective	respective	ADJ
bptjm-64	6	28	immunotherapies	immunotherapy	NOUN
bptjm-64	6	29	.	.	PUNCT
bptjm-64	7	1	cancers	cancer	NOUN
bptjm-64	7	2	covered	cover	VERB
bptjm-64	7	3	include	include	VERB
bptjm-64	7	4	non	non	ADJ
bptjm-64	7	5	-	-	ADJ
bptjm-64	7	6	small	small	ADJ
bptjm-64	7	7	cell	cell	NOUN
bptjm-64	7	8	lung	lung	NOUN
bptjm-64	7	9	cancer	cancer	NOUN
bptjm-64	7	10	(	(	PUNCT
bptjm-64	7	11	nsclc	nsclc	NOUN
bptjm-64	7	12	)	)	PUNCT
bptjm-64	7	13	,	,	PUNCT
bptjm-64	7	14	pancreatic	pancreatic	ADJ
bptjm-64	7	15	ductal	ductal	ADJ
bptjm-64	7	16	adenocarcinoma	adenocarcinoma	NOUN
bptjm-64	7	17	(	(	PUNCT
bptjm-64	7	18	pdac	pdac	NOUN
bptjm-64	7	19	)	)	PUNCT
bptjm-64	7	20	,	,	PUNCT
bptjm-64	7	21	cervical	cervical	ADJ
bptjm-64	7	22	cancer	cancer	NOUN
bptjm-64	7	23	,	,	PUNCT
bptjm-64	7	24	chronic	chronic	ADJ
bptjm-64	7	25	lymphocytic	lymphocytic	ADJ
bptjm-64	7	26	leukemia	leukemia	NOUN
bptjm-64	7	27	,	,	PUNCT
bptjm-64	7	28	and	and	CCONJ
bptjm-64	7	29	gastric	gastric	ADJ
bptjm-64	7	30	cancers	cancer	NOUN
bptjm-64	7	31	.	.	PUNCT
bptjm-64	8	1	the	the	DET
bptjm-64	8	2	review	review	NOUN
bptjm-64	8	3	also	also	ADV
bptjm-64	8	4	addresses	address	VERB
bptjm-64	8	5	future	future	ADJ
bptjm-64	8	6	research	research	NOUN
bptjm-64	8	7	directions	direction	NOUN
bptjm-64	8	8	and	and	CCONJ
bptjm-64	8	9	applications	application	NOUN
bptjm-64	8	10	of	of	ADP
bptjm-64	8	11	immunotherapies	immunotherapy	NOUN
bptjm-64	8	12	,	,	PUNCT
bptjm-64	8	13	aspiring	aspire	VERB
bptjm-64	8	14	to	to	PART
bptjm-64	8	15	advance	advance	VERB
bptjm-64	8	16	tme	tme	X
bptjm-64	8	17	understanding	understanding	NOUN
bptjm-64	8	18	and	and	CCONJ
bptjm-64	8	19	research	research	NOUN
bptjm-64	8	20	.	.	PUNCT
bptjm-64	9	1	decoding	decode	VERB
bptjm-64	9	2	the	the	DET
bptjm-64	9	3	interplay	interplay	NOUN
bptjm-64	9	4	:	:	PUNCT
bptjm-64	9	5	exploring	explore	VERB
bptjm-64	9	6	immunotherapy	immunotherapy	NOUN
bptjm-64	9	7	resistance	resistance	NOUN
bptjm-64	9	8	in	in	ADP
bptjm-64	9	9	the	the	DET
bptjm-64	9	10	tumor	tumor	NOUN
bptjm-64	9	11	microenvironment	microenvironment	NOUN
bptjm-64	9	12	by	by	ADP
bptjm-64	9	13	:	:	PUNCT
bptjm-64	9	14	sanchitha	sanchitha	PROPN
bptjm-64	9	15	kannabran	kannabran	PROPN
bptjm-64	9	16	,	,	PUNCT
bptjm-64	9	17	akshaya	akshaya	PROPN
bptjm-64	9	18	ajan	ajan	PROPN
bptjm-64	9	19	,	,	PUNCT
bptjm-64	9	20	leanne	leanne	PROPN
bptjm-64	9	21	lui	lui	PROPN
bptjm-64	9	22	,	,	PUNCT
bptjm-64	9	23	zaden	zaden	ADJ
bptjm-64	9	24	yet	yet	ADV
bptjm-64	9	25	1	1	NUM
bptjm-64	9	26	.	.	X
bptjm-64	10	1	introduction	introduction	NOUN
bptjm-64	10	2	the	the	DET
bptjm-64	10	3	tumor	tumor	NOUN
bptjm-64	10	4	microenvironment	microenvironment	NOUN
bptjm-64	10	5	(	(	PUNCT
bptjm-64	10	6	tme	tme	NOUN
bptjm-64	10	7	)	)	PUNCT
bptjm-64	10	8	constitutes	constitute	VERB
bptjm-64	10	9	the	the	DET
bptjm-64	10	10	immediate	immediate	ADJ
bptjm-64	10	11	surroundings	surrounding	NOUN
bptjm-64	10	12	of	of	ADP
bptjm-64	10	13	a	a	DET
bptjm-64	10	14	tumor	tumor	NOUN
bptjm-64	10	15	,	,	PUNCT
bptjm-64	10	16	forming	form	VERB
bptjm-64	10	17	a	a	DET
bptjm-64	10	18	complex	complex	ADJ
bptjm-64	10	19	ecosystem	ecosystem	NOUN
bptjm-64	10	20	inclusive	inclusive	NOUN
bptjm-64	10	21	of	of	ADP
bptjm-64	10	22	nearby	nearby	ADJ
bptjm-64	10	23	blood	blood	NOUN
bptjm-64	10	24	vessels	vessel	NOUN
bptjm-64	10	25	,	,	PUNCT
bptjm-64	10	26	immune	immune	ADJ
bptjm-64	10	27	cells	cell	NOUN
bptjm-64	10	28	,	,	PUNCT
bptjm-64	10	29	�	�	NOUN
bptjm-64	10	30	broblasts	broblast	NOUN
bptjm-64	10	31	,	,	PUNCT
bptjm-64	10	32	signaling	signal	VERB
bptjm-64	10	33	molecules	molecule	NOUN
bptjm-64	10	34	,	,	PUNCT
bptjm-64	10	35	and	and	CCONJ
bptjm-64	10	36	the	the	DET
bptjm-64	10	37	extracellular	extracellular	ADJ
bptjm-64	10	38	matrix	matrix	NOUN
bptjm-64	10	39	(	(	PUNCT
bptjm-64	10	40	ecm).1	ecm).1	X
bptjm-64	10	41	within	within	ADP
bptjm-64	10	42	the	the	DET
bptjm-64	10	43	tme	tme	NOUN
bptjm-64	10	44	,	,	PUNCT
bptjm-64	10	45	there	there	PRON
bptjm-64	10	46	exist	exist	VERB
bptjm-64	10	47	hypoxic	hypoxic	ADJ
bptjm-64	10	48	and	and	CCONJ
bptjm-64	10	49	acidic	acidic	ADJ
bptjm-64	10	50	conditions	condition	NOUN
bptjm-64	10	51	,	,	PUNCT
bptjm-64	10	52	alongside	alongside	ADP
bptjm-64	10	53	altered	alter	VERB
bptjm-64	10	54	expression	expression	NOUN
bptjm-64	10	55	patterns	pattern	NOUN
bptjm-64	10	56	of	of	ADP
bptjm-64	10	57	ecm	ecm	PROPN
bptjm-64	10	58	proteins	protein	NOUN
bptjm-64	10	59	.	.	PUNCT
bptjm-64	11	1	these	these	DET
bptjm-64	11	2	conditions	condition	NOUN
bptjm-64	11	3	foster	foster	VERB
bptjm-64	11	4	the	the	DET
bptjm-64	11	5	presence	presence	NOUN
bptjm-64	11	6	of	of	ADP
bptjm-64	11	7	resident	resident	NOUN
bptjm-64	11	8	and	and	CCONJ
bptjm-64	11	9	in	in	ADP
bptjm-64	11	10	�	�	PROPN
bptjm-64	11	11	ltrating	ltrate	VERB
bptjm-64	11	12	immunosuppressive	immunosuppressive	ADJ
bptjm-64	11	13	cells	cell	NOUN
bptjm-64	11	14	,	,	PUNCT
bptjm-64	11	15	trigger	trigger	VERB
bptjm-64	11	16	the	the	DET
bptjm-64	11	17	expression	expression	NOUN
bptjm-64	11	18	of	of	ADP
bptjm-64	11	19	immune	immune	ADJ
bptjm-64	11	20	checkpoint	checkpoint	NOUN
bptjm-64	11	21	proteins	protein	NOUN
bptjm-64	11	22	,	,	PUNCT
bptjm-64	11	23	and	and	CCONJ
bptjm-64	11	24	promote	promote	VERB
bptjm-64	11	25	the	the	DET
bptjm-64	11	26	exclusion	exclusion	NOUN
bptjm-64	11	27	and	and	CCONJ
bptjm-64	11	28	exhaustion	exhaustion	NOUN
bptjm-64	11	29	of	of	ADP
bptjm-64	11	30	cytotoxic	cytotoxic	ADJ
bptjm-64	11	31	t	t	NOUN
bptjm-64	11	32	lymphocytes	lymphocyte	NOUN
bptjm-64	11	33	(	(	PUNCT
bptjm-64	11	34	ctls).2	ctls).2	AUX
bptjm-64	11	35	such	such	ADJ
bptjm-64	11	36	circumstances	circumstance	NOUN
bptjm-64	11	37	serve	serve	VERB
bptjm-64	11	38	as	as	ADP
bptjm-64	11	39	the	the	DET
bptjm-64	11	40	foundation	foundation	NOUN
bptjm-64	11	41	for	for	ADP
bptjm-64	11	42	immunotherapy	immunotherapy	NOUN
bptjm-64	11	43	targeting	target	VERB
bptjm-64	11	44	the	the	DET
bptjm-64	11	45	tme	tme	NOUN
bptjm-64	11	46	.	.	PUNCT
bptjm-64	12	1	while	while	SCONJ
bptjm-64	12	2	contemporary	contemporary	ADJ
bptjm-64	12	3	interest	interest	NOUN
bptjm-64	12	4	in	in	ADP
bptjm-64	12	5	tme	tme	PROPN
bptjm-64	12	6	immunotherapy	immunotherapy	NOUN
bptjm-64	12	7	appears	appear	VERB
bptjm-64	12	8	recent	recent	ADJ
bptjm-64	12	9	,	,	PUNCT
bptjm-64	12	10	investigations	investigation	NOUN
bptjm-64	12	11	into	into	ADP
bptjm-64	12	12	utilizing	utilize	VERB
bptjm-64	12	13	immune	immune	ADJ
bptjm-64	12	14	cells	cell	NOUN
bptjm-64	12	15	for	for	ADP
bptjm-64	12	16	combating	combat	VERB
bptjm-64	12	17	tumors	tumor	NOUN
bptjm-64	12	18	date	date	VERB
bptjm-64	12	19	back	back	ADV
bptjm-64	12	20	to	to	ADP
bptjm-64	12	21	the	the	DET
bptjm-64	12	22	1900s.3	1900s.3	ADJ
bptjm-64	12	23	new	new	ADJ
bptjm-64	12	24	studies	study	NOUN
bptjm-64	12	25	are	be	AUX
bptjm-64	12	26	directed	direct	VERB
bptjm-64	12	27	towards	towards	ADP
bptjm-64	12	28	pinpointing	pinpoint	VERB
bptjm-64	12	29	cellular	cellular	ADJ
bptjm-64	12	30	pathways	pathway	NOUN
bptjm-64	12	31	within	within	ADP
bptjm-64	12	32	the	the	DET
bptjm-64	12	33	tme	tme	NOUN
bptjm-64	12	34	with	with	ADP
bptjm-64	12	35	the	the	DET
bptjm-64	12	36	use	use	NOUN
bptjm-64	12	37	of	of	ADP
bptjm-64	12	38	immunotherapy	immunotherapy	NOUN
bptjm-64	12	39	components	component	NOUN
bptjm-64	12	40	to	to	PART
bptjm-64	12	41	hinder	hinder	VERB
bptjm-64	12	42	growth	growth	NOUN
bptjm-64	12	43	.	.	PUNCT
bptjm-64	13	1	among	among	ADP
bptjm-64	13	2	the	the	DET
bptjm-64	13	3	primary	primary	ADJ
bptjm-64	13	4	pathways	pathway	NOUN
bptjm-64	13	5	are	be	AUX
bptjm-64	13	6	lactic	lactic	ADJ
bptjm-64	13	7	acid	acid	NOUN
bptjm-64	13	8	accumulation	accumulation	NOUN
bptjm-64	13	9	,	,	PUNCT
bptjm-64	13	10	metabolic	metabolic	NOUN
bptjm-64	13	11	processes	process	NOUN
bptjm-64	13	12	,	,	PUNCT
bptjm-64	13	13	and	and	CCONJ
bptjm-64	13	14	diverse	diverse	ADJ
bptjm-64	13	15	signaling	signal	VERB
bptjm-64	13	16	routes	route	NOUN
bptjm-64	13	17	within	within	ADP
bptjm-64	13	18	the	the	DET
bptjm-64	13	19	tme	tme	NOUN
bptjm-64	13	20	.	.	PUNCT
bptjm-64	14	1	5,6,7	5,6,7	NUM
bptjm-64	14	2	all	all	DET
bptjm-64	14	3	these	these	DET
bptjm-64	14	4	pathways	pathway	NOUN
bptjm-64	14	5	represent	represent	VERB
bptjm-64	14	6	potential	potential	ADJ
bptjm-64	14	7	targets	target	NOUN
bptjm-64	14	8	for	for	ADP
bptjm-64	14	9	immunotherapy	immunotherapy	NOUN
bptjm-64	14	10	interventions	intervention	NOUN
bptjm-64	14	11	.	.	PUNCT
bptjm-64	15	1	moreover	moreover	ADV
bptjm-64	15	2	,	,	PUNCT
bptjm-64	15	3	treatments	treatment	NOUN
bptjm-64	15	4	are	be	AUX
bptjm-64	15	5	geared	gear	VERB
bptjm-64	15	6	towards	towards	ADP
bptjm-64	15	7	enhancing	enhance	VERB
bptjm-64	15	8	the	the	DET
bptjm-64	15	9	immune	immune	ADJ
bptjm-64	15	10	system	system	NOUN
bptjm-64	15	11	's	's	PART
bptjm-64	15	12	ability	ability	NOUN
bptjm-64	15	13	to	to	PART
bptjm-64	15	14	eradicate	eradicate	VERB
bptjm-64	15	15	cancer	cancer	NOUN
bptjm-64	15	16	cells	cell	NOUN
bptjm-64	15	17	and	and	CCONJ
bptjm-64	15	18	impede	impede	VERB
bptjm-64	15	19	their	their	PRON
bptjm-64	15	20	proliferation	proliferation	NOUN
bptjm-64	15	21	.	.	PUNCT
bptjm-64	16	1	to	to	PART
bptjm-64	16	2	achieve	achieve	VERB
bptjm-64	16	3	this	this	DET
bptjm-64	16	4	goal	goal	NOUN
bptjm-64	16	5	,	,	PUNCT
bptjm-64	16	6	two	two	NUM
bptjm-64	16	7	primary	primary	ADJ
bptjm-64	16	8	strategies	strategy	NOUN
bptjm-64	16	9	are	be	AUX
bptjm-64	16	10	employed	employ	VERB
bptjm-64	16	11	:	:	PUNCT
bptjm-64	16	12	immune	immune	ADJ
bptjm-64	16	13	checkpoint	checkpoint	NOUN
bptjm-64	16	14	inhibition	inhibition	NOUN
bptjm-64	16	15	and	and	CCONJ
bptjm-64	16	16	adoptive	adoptive	ADJ
bptjm-64	16	17	cellular	cellular	ADJ
bptjm-64	16	18	therapy	therapy	NOUN
bptjm-64	16	19	(	(	PUNCT
bptjm-64	16	20	act).4	act).4	NOUN
bptjm-64	16	21	immune	immune	ADJ
bptjm-64	16	22	checkpoint	checkpoint	NOUN
bptjm-64	16	23	inhibition	inhibition	NOUN
bptjm-64	16	24	involves	involve	VERB
bptjm-64	16	25	obstructing	obstruct	VERB
bptjm-64	16	26	certain	certain	ADJ
bptjm-64	16	27	proteins	protein	NOUN
bptjm-64	16	28	,	,	PUNCT
bptjm-64	16	29	known	know	VERB
bptjm-64	16	30	as	as	ADP
bptjm-64	16	31	checkpoints	checkpoint	NOUN
bptjm-64	16	32	,	,	PUNCT
bptjm-64	16	33	to	to	PART
bptjm-64	16	34	enhance	enhance	VERB
bptjm-64	16	35	the	the	DET
bptjm-64	16	36	responsiveness	responsiveness	NOUN
bptjm-64	16	37	of	of	ADP
bptjm-64	16	38	immune	immune	ADJ
bptjm-64	16	39	cells.4	cells.4	PROPN
bptjm-64	16	40	adoptive	adoptive	ADJ
bptjm-64	16	41	cell	cell	NOUN
bptjm-64	16	42	therapy	therapy	NOUN
bptjm-64	16	43	(	(	PUNCT
bptjm-64	16	44	act	act	PROPN
bptjm-64	16	45	)	)	PUNCT
bptjm-64	16	46	entails	entail	VERB
bptjm-64	16	47	administering	administer	VERB
bptjm-64	16	48	t	t	NOUN
bptjm-64	16	49	cells	cell	NOUN
bptjm-64	16	50	to	to	ADP
bptjm-64	16	51	patients	patient	NOUN
bptjm-64	16	52	to	to	PART
bptjm-64	16	53	bolster	bolster	VERB
bptjm-64	16	54	their	their	PRON
bptjm-64	16	55	ability	ability	NOUN
bptjm-64	16	56	to	to	PART
bptjm-64	16	57	combat	combat	VERB
bptjm-64	16	58	tumor	tumor	NOUN
bptjm-64	16	59	cells.4	cells.4	PROPN
bptjm-64	16	60	in	in	ADP
bptjm-64	16	61	this	this	DET
bptjm-64	16	62	discussion	discussion	NOUN
bptjm-64	16	63	,	,	PUNCT
bptjm-64	16	64	our	our	PRON
bptjm-64	16	65	focus	focus	NOUN
bptjm-64	16	66	lies	lie	VERB
bptjm-64	16	67	on	on	ADP
bptjm-64	16	68	t	t	PROPN
bptjm-64	16	69	cell	cell	NOUN
bptjm-64	16	70	-	-	PUNCT
bptjm-64	16	71	based	base	VERB
bptjm-64	16	72	immunotherapies	immunotherapy	NOUN
bptjm-64	16	73	,	,	PUNCT
bptjm-64	16	74	including	include	VERB
bptjm-64	16	75	anti	anti	ADJ
bptjm-64	16	76	-	-	ADJ
bptjm-64	16	77	pd-1	pd-1	ADJ
bptjm-64	16	78	/	/	SYM
bptjm-64	16	79	pd	pd	NOUN
bptjm-64	16	80	-	-	PUNCT
bptjm-64	16	81	l1	l1	PROPN
bptjm-64	16	82	,	,	PUNCT
bptjm-64	16	83	anti	anti	ADJ
bptjm-64	16	84	-	-	ADJ
bptjm-64	16	85	ctla-4	ctla-4	NOUN
bptjm-64	16	86	,	,	PUNCT
bptjm-64	16	87	vegf	vegf	PROPN
bptjm-64	16	88	,	,	PUNCT
bptjm-64	16	89	interferon	interferon	PROPN
bptjm-64	16	90	-	-	PUNCT
bptjm-64	16	91	ɣ	ɣ	PROPN
bptjm-64	16	92	(	(	PUNCT
bptjm-64	16	93	ifn	ifn	PROPN
bptjm-64	16	94	-	-	PUNCT
bptjm-64	16	95	ɣ	ɣ	PROPN
bptjm-64	16	96	)	)	PUNCT
bptjm-64	16	97	,	,	PUNCT
bptjm-64	16	98	lag-3	lag-3	NUM
bptjm-64	16	99	,	,	PUNCT
bptjm-64	16	100	and	and	CCONJ
bptjm-64	16	101	er	er	INTJ
bptjm-64	16	102	stress	stress	NOUN
bptjm-64	16	103	-	-	PUNCT
bptjm-64	16	104	xbp1	xbp1	PROPN
bptjm-64	16	105	.	.	PUNCT
bptjm-64	17	1	however	however	ADV
bptjm-64	17	2	,	,	PUNCT
bptjm-64	17	3	the	the	DET
bptjm-64	17	4	complexity	complexity	NOUN
bptjm-64	17	5	of	of	ADP
bptjm-64	17	6	immunotherapy	immunotherapy	NOUN
bptjm-64	17	7	arises	arise	VERB
bptjm-64	17	8	from	from	ADP
bptjm-64	17	9	the	the	DET
bptjm-64	17	10	variable	variable	ADJ
bptjm-64	17	11	responses	response	NOUN
bptjm-64	17	12	of	of	ADP
bptjm-64	17	13	individual	individual	ADJ
bptjm-64	17	14	cancers	cancer	NOUN
bptjm-64	17	15	to	to	PART
bptjm-64	17	16	di	di	NOUN
bptjm-64	17	17	�	�	PROPN
bptjm-64	17	18	erent	erent	NOUN
bptjm-64	17	19	immunotherapeutic	immunotherapeutic	ADJ
bptjm-64	17	20	approaches	approach	NOUN
bptjm-64	17	21	.	.	PUNCT
bptjm-64	18	1	this	this	DET
bptjm-64	18	2	review	review	NOUN
bptjm-64	18	3	delves	delve	VERB
bptjm-64	18	4	into	into	ADP
bptjm-64	18	5	the	the	DET
bptjm-64	18	6	distinctive	distinctive	ADJ
bptjm-64	18	7	attributes	attribute	NOUN
bptjm-64	18	8	of	of	ADP
bptjm-64	18	9	cancers	cancer	NOUN
bptjm-64	18	10	such	such	ADJ
bptjm-64	18	11	as	as	ADP
bptjm-64	18	12	non	non	ADJ
bptjm-64	18	13	-	-	ADJ
bptjm-64	18	14	small	small	ADJ
bptjm-64	18	15	cell	cell	NOUN
bptjm-64	18	16	lung	lung	NOUN
bptjm-64	18	17	cancer	cancer	NOUN
bptjm-64	18	18	(	(	PUNCT
bptjm-64	18	19	nsclc	nsclc	NOUN
bptjm-64	18	20	)	)	PUNCT
bptjm-64	18	21	,	,	PUNCT
bptjm-64	18	22	berkeley	berkeley	PROPN
bptjm-64	18	23	pharma	pharma	PROPN
bptjm-64	18	24	tech	tech	NOUN
bptjm-64	18	25	journal	journal	NOUN
bptjm-64	18	26	of	of	ADP
bptjm-64	18	27	medicine	medicine	NOUN
bptjm-64	18	28	|	|	ADV
bptjm-64	18	29	114	114	NUM
bptjm-64	18	30	melanoma	melanoma	NOUN
bptjm-64	18	31	,	,	PUNCT
bptjm-64	18	32	pancreatic	pancreatic	ADJ
bptjm-64	18	33	cancer	cancer	NOUN
bptjm-64	18	34	,	,	PUNCT
bptjm-64	18	35	cervical	cervical	ADJ
bptjm-64	18	36	cancer	cancer	NOUN
bptjm-64	18	37	,	,	PUNCT
bptjm-64	18	38	and	and	CCONJ
bptjm-64	18	39	chronic	chronic	ADJ
bptjm-64	18	40	lymphocytic	lymphocytic	ADJ
bptjm-64	18	41	leukemia	leukemia	NOUN
bptjm-64	18	42	.	.	PUNCT
bptjm-64	19	1	2	2	X
bptjm-64	19	2	.	.	NOUN
bptjm-64	19	3	immune	immune	ADJ
bptjm-64	19	4	cell	cell	NOUN
bptjm-64	19	5	overview	overview	VERB
bptjm-64	19	6	the	the	DET
bptjm-64	19	7	extracellular	extracellular	ADJ
bptjm-64	19	8	matrix	matrix	NOUN
bptjm-64	19	9	(	(	PUNCT
bptjm-64	19	10	ecm	ecm	PROPN
bptjm-64	19	11	)	)	PUNCT
bptjm-64	19	12	is	be	AUX
bptjm-64	19	13	comprised	comprise	VERB
bptjm-64	19	14	of	of	ADP
bptjm-64	19	15	collagen	collagen	NOUN
bptjm-64	19	16	,	,	PUNCT
bptjm-64	19	17	�	�	PROPN
bptjm-64	19	18	bronectin	bronectin	PROPN
bptjm-64	19	19	,	,	PUNCT
bptjm-64	19	20	elastin	elastin	NOUN
bptjm-64	19	21	,	,	PUNCT
bptjm-64	19	22	and	and	CCONJ
bptjm-64	19	23	laminin	laminin	NOUN
bptjm-64	19	24	,	,	PUNCT
bptjm-64	19	25	serving	serve	VERB
bptjm-64	19	26	as	as	ADP
bptjm-64	19	27	the	the	DET
bptjm-64	19	28	structural	structural	ADJ
bptjm-64	19	29	framework	framework	NOUN
bptjm-64	19	30	within	within	ADP
bptjm-64	19	31	the	the	DET
bptjm-64	19	32	tumor	tumor	NOUN
bptjm-64	19	33	microenvironment	microenvironment	NOUN
bptjm-64	19	34	(	(	PUNCT
bptjm-64	19	35	tme	tme	NOUN
bptjm-64	19	36	)	)	PUNCT
bptjm-64	19	37	.	.	PUNCT
bptjm-64	20	1	within	within	ADP
bptjm-64	20	2	this	this	DET
bptjm-64	20	3	environment	environment	NOUN
bptjm-64	20	4	,	,	PUNCT
bptjm-64	20	5	various	various	ADJ
bptjm-64	20	6	immune	immune	ADJ
bptjm-64	20	7	cells	cell	NOUN
bptjm-64	20	8	including	include	VERB
bptjm-64	20	9	t	t	NOUN
bptjm-64	20	10	cells	cell	NOUN
bptjm-64	20	11	,	,	PUNCT
bptjm-64	20	12	b	b	NOUN
bptjm-64	20	13	cells	cell	NOUN
bptjm-64	20	14	,	,	PUNCT
bptjm-64	20	15	natural	natural	ADJ
bptjm-64	20	16	killer	killer	NOUN
bptjm-64	20	17	cells	cell	NOUN
bptjm-64	20	18	(	(	PUNCT
bptjm-64	20	19	nk	nk	PROPN
bptjm-64	20	20	)	)	PUNCT
bptjm-64	20	21	,	,	PUNCT
bptjm-64	20	22	macrophages	macrophage	NOUN
bptjm-64	20	23	(	(	PUNCT
bptjm-64	20	24	m1	m1	PROPN
bptjm-64	20	25	and	and	CCONJ
bptjm-64	20	26	m2	m2	PROPN
bptjm-64	20	27	)	)	PUNCT
bptjm-64	20	28	,	,	PUNCT
bptjm-64	20	29	stromal	stromal	ADJ
bptjm-64	20	30	cells	cell	NOUN
bptjm-64	20	31	,	,	PUNCT
bptjm-64	20	32	endothelial	endothelial	ADJ
bptjm-64	20	33	cells	cell	NOUN
bptjm-64	20	34	,	,	PUNCT
bptjm-64	20	35	and	and	CCONJ
bptjm-64	20	36	cancer	cancer	NOUN
bptjm-64	20	37	-	-	PUNCT
bptjm-64	20	38	associated	associate	VERB
bptjm-64	20	39	�	�	NOUN
bptjm-64	20	40	broblasts	broblast	NOUN
bptjm-64	20	41	(	(	PUNCT
bptjm-64	20	42	cafs	cafs	NOUN
bptjm-64	20	43	)	)	PUNCT
bptjm-64	20	44	play	play	VERB
bptjm-64	20	45	pivotal	pivotal	ADJ
bptjm-64	20	46	roles	role	NOUN
bptjm-64	20	47	in	in	ADP
bptjm-64	20	48	either	either	CCONJ
bptjm-64	20	49	promoting	promote	VERB
bptjm-64	20	50	or	or	CCONJ
bptjm-64	20	51	suppressing	suppress	VERB
bptjm-64	20	52	tumor	tumor	NOUN
bptjm-64	20	53	growth.8	growth.8	PROPN
bptjm-64	20	54	t	t	NOUN
bptjm-64	20	55	cells	cell	NOUN
bptjm-64	20	56	,	,	PUNCT
bptjm-64	20	57	equipped	equip	VERB
bptjm-64	20	58	with	with	ADP
bptjm-64	20	59	t	t	NOUN
bptjm-64	20	60	-	-	PUNCT
bptjm-64	20	61	cell	cell	NOUN
bptjm-64	20	62	receptors	receptor	NOUN
bptjm-64	20	63	,	,	PUNCT
bptjm-64	20	64	target	target	NOUN
bptjm-64	20	65	speci	speci	PROPN
bptjm-64	20	66	�	�	PROPN
bptjm-64	20	67	c	c	NOUN
bptjm-64	20	68	antigens	antigen	NOUN
bptjm-64	20	69	on	on	ADP
bptjm-64	20	70	tumor	tumor	NOUN
bptjm-64	20	71	cells	cell	NOUN
bptjm-64	20	72	,	,	PUNCT
bptjm-64	20	73	halting	halting	ADJ
bptjm-64	20	74	angiogenesis	angiogenesis	NOUN
bptjm-64	20	75	—	—	PUNCT
bptjm-64	20	76	the	the	DET
bptjm-64	20	77	formation	formation	NOUN
bptjm-64	20	78	of	of	ADP
bptjm-64	20	79	new	new	ADJ
bptjm-64	20	80	blood	blood	NOUN
bptjm-64	20	81	vessels	vessel	NOUN
bptjm-64	20	82	—	—	PUNCT
bptjm-64	20	83	and	and	CCONJ
bptjm-64	20	84	leading	lead	VERB
bptjm-64	20	85	to	to	ADP
bptjm-64	20	86	tumor	tumor	NOUN
bptjm-64	20	87	cell	cell	NOUN
bptjm-64	20	88	destruction	destruction	NOUN
bptjm-64	20	89	.	.	PUNCT
bptjm-64	21	1	however	however	ADV
bptjm-64	21	2	,	,	PUNCT
bptjm-64	21	3	t	t	PROPN
bptjm-64	21	4	cells	cell	NOUN
bptjm-64	21	5	can	can	AUX
bptjm-64	21	6	become	become	VERB
bptjm-64	21	7	in	in	ADP
bptjm-64	21	8	�	�	NOUN
bptjm-64	21	9	ltrated	ltrate	VERB
bptjm-64	21	10	and	and	CCONJ
bptjm-64	21	11	dysfunctional	dysfunctional	ADJ
bptjm-64	21	12	within	within	ADP
bptjm-64	21	13	the	the	DET
bptjm-64	21	14	immune	immune	ADJ
bptjm-64	21	15	system.8,9	system.8,9	PROPN
bptjm-64	21	16	b	b	PROPN
bptjm-64	21	17	cells	cell	NOUN
bptjm-64	21	18	contribute	contribute	VERB
bptjm-64	21	19	to	to	ADP
bptjm-64	21	20	antibody	antibody	NOUN
bptjm-64	21	21	production	production	NOUN
bptjm-64	21	22	,	,	PUNCT
bptjm-64	21	23	antigen	antigen	ADJ
bptjm-64	21	24	presentation	presentation	NOUN
bptjm-64	21	25	,	,	PUNCT
bptjm-64	21	26	and	and	CCONJ
bptjm-64	21	27	cytokine	cytokine	VERB
bptjm-64	21	28	secretion	secretion	NOUN
bptjm-64	21	29	.	.	PUNCT
bptjm-64	22	1	8,9	8,9	NUM
bptjm-64	22	2	in	in	ADP
bptjm-64	22	3	the	the	DET
bptjm-64	22	4	context	context	NOUN
bptjm-64	22	5	of	of	ADP
bptjm-64	22	6	lymphocytes	lymphocyte	NOUN
bptjm-64	22	7	,	,	PUNCT
bptjm-64	22	8	both	both	PRON
bptjm-64	22	9	t	t	PROPN
bptjm-64	22	10	and	and	CCONJ
bptjm-64	22	11	b	b	PROPN
bptjm-64	22	12	cells	cell	NOUN
bptjm-64	22	13	,	,	PUNCT
bptjm-64	22	14	particularly	particularly	ADV
bptjm-64	22	15	tumor	tumor	NOUN
bptjm-64	22	16	-	-	PUNCT
bptjm-64	22	17	in	in	ADP
bptjm-64	22	18	�	�	NOUN
bptjm-64	22	19	ltrating	ltrating	NOUN
bptjm-64	22	20	lymphocytes	lymphocyte	NOUN
bptjm-64	22	21	(	(	PUNCT
bptjm-64	22	22	tils	til	NOUN
bptjm-64	22	23	)	)	PUNCT
bptjm-64	22	24	,	,	PUNCT
bptjm-64	22	25	are	be	AUX
bptjm-64	22	26	crucial	crucial	ADJ
bptjm-64	22	27	in	in	ADP
bptjm-64	22	28	research	research	NOUN
bptjm-64	22	29	.	.	PUNCT
bptjm-64	23	1	while	while	SCONJ
bptjm-64	23	2	tils	til	VERB
bptjm-64	23	3	e	e	NOUN
bptjm-64	23	4	�	�	NOUN
bptjm-64	23	5	ectively	ectively	ADV
bptjm-64	23	6	eliminate	eliminate	VERB
bptjm-64	23	7	tumor	tumor	NOUN
bptjm-64	23	8	cells	cell	NOUN
bptjm-64	23	9	,	,	PUNCT
bptjm-64	23	10	they	they	PRON
bptjm-64	23	11	can	can	AUX
bptjm-64	23	12	be	be	AUX
bptjm-64	23	13	recruited	recruit	VERB
bptjm-64	23	14	by	by	ADP
bptjm-64	23	15	the	the	DET
bptjm-64	23	16	tme	tme	PROPN
bptjm-64	23	17	,	,	PUNCT
bptjm-64	23	18	compromising	compromise	VERB
bptjm-64	23	19	immune	immune	ADJ
bptjm-64	23	20	response	response	NOUN
bptjm-64	23	21	e	e	NOUN
bptjm-64	23	22	�	�	NOUN
bptjm-64	23	23	cacy.4	cacy.4	VERB
bptjm-64	23	24	regulatory	regulatory	ADJ
bptjm-64	23	25	t	t	NOUN
bptjm-64	23	26	cells	cell	NOUN
bptjm-64	23	27	(	(	PUNCT
bptjm-64	23	28	tregs	treg	NOUN
bptjm-64	23	29	)	)	PUNCT
bptjm-64	23	30	maintain	maintain	VERB
bptjm-64	23	31	immune	immune	ADJ
bptjm-64	23	32	response	response	NOUN
bptjm-64	23	33	balance	balance	NOUN
bptjm-64	23	34	,	,	PUNCT
bptjm-64	23	35	but	but	CCONJ
bptjm-64	23	36	when	when	SCONJ
bptjm-64	23	37	recruited	recruit	VERB
bptjm-64	23	38	to	to	ADP
bptjm-64	23	39	the	the	DET
bptjm-64	23	40	tme	tme	NOUN
bptjm-64	23	41	,	,	PUNCT
bptjm-64	23	42	they	they	PRON
bptjm-64	23	43	hinder	hinder	VERB
bptjm-64	23	44	t	t	PROPN
bptjm-64	23	45	cell	cell	NOUN
bptjm-64	23	46	formation	formation	NOUN
bptjm-64	23	47	,	,	PUNCT
bptjm-64	23	48	posing	pose	VERB
bptjm-64	23	49	a	a	DET
bptjm-64	23	50	danger	danger	NOUN
bptjm-64	23	51	to	to	ADP
bptjm-64	23	52	immune	immune	ADJ
bptjm-64	23	53	function	function	NOUN
bptjm-64	23	54	.	.	PUNCT
bptjm-64	24	1	consequently	consequently	ADV
bptjm-64	24	2	,	,	PUNCT
bptjm-64	24	3	immune	immune	ADJ
bptjm-64	24	4	mechanisms	mechanism	NOUN
bptjm-64	24	5	originally	originally	ADV
bptjm-64	24	6	aimed	aim	VERB
bptjm-64	24	7	at	at	ADP
bptjm-64	24	8	protecting	protect	VERB
bptjm-64	24	9	the	the	DET
bptjm-64	24	10	body	body	NOUN
bptjm-64	24	11	now	now	ADV
bptjm-64	24	12	facilitate	facilitate	VERB
bptjm-64	24	13	tme	tme	X
bptjm-64	24	14	growth.10	growth.10	PROPN
bptjm-64	24	15	nk	nk	PROPN
bptjm-64	24	16	cells	cell	NOUN
bptjm-64	24	17	surveil	surveil	VERB
bptjm-64	24	18	the	the	DET
bptjm-64	24	19	bloodstream	bloodstream	NOUN
bptjm-64	24	20	for	for	ADP
bptjm-64	24	21	tumor	tumor	NOUN
bptjm-64	24	22	cells	cell	NOUN
bptjm-64	24	23	,	,	PUNCT
bptjm-64	24	24	inhibiting	inhibit	VERB
bptjm-64	24	25	metastasis.8,9	metastasis.8,9	NUM
bptjm-64	24	26	macrophages	macrophage	NOUN
bptjm-64	24	27	regulate	regulate	VERB
bptjm-64	24	28	immune	immune	ADJ
bptjm-64	24	29	responses	response	NOUN
bptjm-64	24	30	by	by	ADP
bptjm-64	24	31	phagocytosing	phagocytose	VERB
bptjm-64	24	32	pathogens	pathogen	NOUN
bptjm-64	24	33	and	and	CCONJ
bptjm-64	24	34	presenting	present	VERB
bptjm-64	24	35	antigens	antigen	NOUN
bptjm-64	24	36	.	.	PUNCT
bptjm-64	25	1	notably	notably	ADV
bptjm-64	25	2	,	,	PUNCT
bptjm-64	25	3	increased	increase	VERB
bptjm-64	25	4	macrophage	macrophage	NOUN
bptjm-64	25	5	in	in	ADP
bptjm-64	25	6	�	�	PROPN
bptjm-64	25	7	ltration	ltration	NOUN
bptjm-64	25	8	in	in	ADP
bptjm-64	25	9	tumors	tumor	NOUN
bptjm-64	25	10	,	,	PUNCT
bptjm-64	25	11	particularly	particularly	ADV
bptjm-64	25	12	the	the	DET
bptjm-64	25	13	m2	m2	PROPN
bptjm-64	25	14	phenotype	phenotype	NOUN
bptjm-64	25	15	,	,	PUNCT
bptjm-64	25	16	and	and	CCONJ
bptjm-64	25	17	cytokine	cytokine	VERB
bptjm-64	25	18	secretion	secretion	NOUN
bptjm-64	25	19	,	,	PUNCT
bptjm-64	25	20	support	support	NOUN
bptjm-64	25	21	tumor	tumor	NOUN
bptjm-64	25	22	growth.8,9	growth.8,9	PROPN
bptjm-64	25	23	berkeley	berkeley	PROPN
bptjm-64	25	24	pharma	pharma	PROPN
bptjm-64	25	25	tech	tech	NOUN
bptjm-64	25	26	journal	journal	NOUN
bptjm-64	25	27	of	of	ADP
bptjm-64	25	28	medicine	medicine	NOUN
bptjm-64	25	29	|	|	ADV
bptjm-64	25	30	115	115	NUM
bptjm-64	25	31	figure	figure	NOUN
bptjm-64	25	32	1	1	NUM
bptjm-64	25	33	:	:	PUNCT
bptjm-64	25	34	this	this	DET
bptjm-64	25	35	figure	figure	NOUN
bptjm-64	25	36	illustrates	illustrate	VERB
bptjm-64	25	37	the	the	DET
bptjm-64	25	38	distinct	distinct	ADJ
bptjm-64	25	39	contributions	contribution	NOUN
bptjm-64	25	40	of	of	ADP
bptjm-64	25	41	various	various	ADJ
bptjm-64	25	42	immune	immune	ADJ
bptjm-64	25	43	cells	cell	NOUN
bptjm-64	25	44	to	to	ADP
bptjm-64	25	45	the	the	DET
bptjm-64	25	46	tumor	tumor	NOUN
bptjm-64	25	47	microenvironment	microenvironment	NOUN
bptjm-64	25	48	(	(	PUNCT
bptjm-64	25	49	tme	tme	NOUN
bptjm-64	25	50	)	)	PUNCT
bptjm-64	25	51	.	.	PUNCT
bptjm-64	26	1	it	it	PRON
bptjm-64	26	2	delineates	delineate	VERB
bptjm-64	26	3	the	the	DET
bptjm-64	26	4	overall	overall	ADJ
bptjm-64	26	5	immune	immune	ADJ
bptjm-64	26	6	response	response	NOUN
bptjm-64	26	7	attributed	attribute	VERB
bptjm-64	26	8	to	to	ADP
bptjm-64	26	9	each	each	DET
bptjm-64	26	10	mentioned	mention	VERB
bptjm-64	26	11	immune	immune	ADJ
bptjm-64	26	12	cell	cell	NOUN
bptjm-64	26	13	type	type	NOUN
bptjm-64	26	14	:	:	PUNCT
bptjm-64	26	15	t	t	NOUN
bptjm-64	26	16	cells	cell	NOUN
bptjm-64	26	17	,	,	PUNCT
bptjm-64	26	18	b	b	NOUN
bptjm-64	26	19	cells	cell	NOUN
bptjm-64	26	20	,	,	PUNCT
bptjm-64	26	21	macrophages	macrophage	NOUN
bptjm-64	26	22	(	(	PUNCT
bptjm-64	26	23	m1	m1	PROPN
bptjm-64	26	24	and	and	CCONJ
bptjm-64	26	25	m2	m2	PROPN
bptjm-64	26	26	)	)	PUNCT
bptjm-64	26	27	,	,	PUNCT
bptjm-64	26	28	natural	natural	ADJ
bptjm-64	26	29	killer	killer	NOUN
bptjm-64	26	30	cells	cell	NOUN
bptjm-64	26	31	(	(	PUNCT
bptjm-64	26	32	nk	nk	PROPN
bptjm-64	26	33	)	)	PUNCT
bptjm-64	26	34	,	,	PUNCT
bptjm-64	26	35	tregs	treg	NOUN
bptjm-64	26	36	,	,	PUNCT
bptjm-64	26	37	and	and	CCONJ
bptjm-64	26	38	cd8	cd8	PROPN
bptjm-64	26	39	+	+	PROPN
bptjm-64	26	40	cells	cell	NOUN
bptjm-64	26	41	.	.	PUNCT
bptjm-64	27	1	the	the	DET
bptjm-64	27	2	upper	upper	ADJ
bptjm-64	27	3	side	side	NOUN
bptjm-64	27	4	represents	represent	VERB
bptjm-64	27	5	the	the	DET
bptjm-64	27	6	positive	positive	ADJ
bptjm-64	27	7	immune	immune	ADJ
bptjm-64	27	8	response	response	NOUN
bptjm-64	27	9	,	,	PUNCT
bptjm-64	27	10	while	while	SCONJ
bptjm-64	27	11	the	the	DET
bptjm-64	27	12	lower	low	ADJ
bptjm-64	27	13	side	side	NOUN
bptjm-64	27	14	depicts	depict	VERB
bptjm-64	27	15	the	the	DET
bptjm-64	27	16	autoimmune	autoimmune	ADJ
bptjm-64	27	17	suppressive	suppressive	ADJ
bptjm-64	27	18	response	response	NOUN
bptjm-64	27	19	.	.	PUNCT
bptjm-64	28	1	stromal	stromal	ADJ
bptjm-64	28	2	cells	cell	NOUN
bptjm-64	28	3	,	,	PUNCT
bptjm-64	28	4	including	include	VERB
bptjm-64	28	5	endothelial	endothelial	ADJ
bptjm-64	28	6	cells	cell	NOUN
bptjm-64	28	7	,	,	PUNCT
bptjm-64	28	8	�	�	NOUN
bptjm-64	28	9	broblasts	broblast	NOUN
bptjm-64	28	10	,	,	PUNCT
bptjm-64	28	11	adipocytes	adipocyte	NOUN
bptjm-64	28	12	,	,	PUNCT
bptjm-64	28	13	and	and	CCONJ
bptjm-64	28	14	stellate	stellate	ADJ
bptjm-64	28	15	cells	cell	NOUN
bptjm-64	28	16	,	,	PUNCT
bptjm-64	28	17	play	play	VERB
bptjm-64	28	18	crucial	crucial	ADJ
bptjm-64	28	19	roles	role	NOUN
bptjm-64	28	20	in	in	ADP
bptjm-64	28	21	tumor	tumor	NOUN
bptjm-64	28	22	development	development	NOUN
bptjm-64	28	23	.	.	PUNCT
bptjm-64	29	1	tumor	tumor	NOUN
bptjm-64	29	2	cells	cell	NOUN
bptjm-64	29	3	recruit	recruit	VERB
bptjm-64	29	4	these	these	DET
bptjm-64	29	5	supporting	support	VERB
bptjm-64	29	6	cells	cell	NOUN
bptjm-64	29	7	from	from	ADP
bptjm-64	29	8	nearby	nearby	ADJ
bptjm-64	29	9	tissue	tissue	NOUN
bptjm-64	29	10	to	to	PART
bptjm-64	29	11	aid	aid	VERB
bptjm-64	29	12	in	in	ADP
bptjm-64	29	13	tumor	tumor	NOUN
bptjm-64	29	14	formation	formation	NOUN
bptjm-64	29	15	.	.	PUNCT
bptjm-64	30	1	stromal	stromal	ADJ
bptjm-64	30	2	cells	cell	NOUN
bptjm-64	30	3	secrete	secrete	VERB
bptjm-64	30	4	various	various	ADJ
bptjm-64	30	5	factors	factor	NOUN
bptjm-64	30	6	that	that	SCONJ
bptjm-64	30	7	in	in	ADP
bptjm-64	30	8	�	�	NOUN
bptjm-64	30	9	uence	uence	NOUN
bptjm-64	30	10	processes	process	NOUN
bptjm-64	30	11	like	like	ADP
bptjm-64	30	12	angiogenesis	angiogenesis	NOUN
bptjm-64	30	13	,	,	PUNCT
bptjm-64	30	14	proliferation	proliferation	NOUN
bptjm-64	30	15	,	,	PUNCT
bptjm-64	30	16	invasion	invasion	NOUN
bptjm-64	30	17	,	,	PUNCT
bptjm-64	30	18	and	and	CCONJ
bptjm-64	30	19	metastasis.8,9	metastasis.8,9	PRON
bptjm-64	30	20	endothelial	endothelial	ADJ
bptjm-64	30	21	cells	cell	NOUN
bptjm-64	30	22	,	,	PUNCT
bptjm-64	30	23	for	for	ADP
bptjm-64	30	24	instance	instance	NOUN
bptjm-64	30	25	,	,	PUNCT
bptjm-64	30	26	are	be	AUX
bptjm-64	30	27	pivotal	pivotal	ADJ
bptjm-64	30	28	in	in	ADP
bptjm-64	30	29	orchestrating	orchestrate	VERB
bptjm-64	30	30	blood	blood	NOUN
bptjm-64	30	31	vessel	vessel	NOUN
bptjm-64	30	32	formation	formation	NOUN
bptjm-64	30	33	and	and	CCONJ
bptjm-64	30	34	signi	signi	PROPN
bptjm-64	30	35	�	�	PROPN
bptjm-64	30	36	cantly	cantly	ADV
bptjm-64	30	37	contribute	contribute	VERB
bptjm-64	30	38	to	to	ADP
bptjm-64	30	39	cancer	cancer	NOUN
bptjm-64	30	40	progression	progression	NOUN
bptjm-64	30	41	by	by	ADP
bptjm-64	30	42	promoting	promote	VERB
bptjm-64	30	43	cancer	cancer	NOUN
bptjm-64	30	44	cell	cell	NOUN
bptjm-64	30	45	migration	migration	NOUN
bptjm-64	30	46	,	,	PUNCT
bptjm-64	30	47	invasion	invasion	NOUN
bptjm-64	30	48	,	,	PUNCT
bptjm-64	30	49	angiogenesis	angiogenesis	NOUN
bptjm-64	30	50	,	,	PUNCT
bptjm-64	30	51	and	and	CCONJ
bptjm-64	30	52	metastasis	metastasis	NOUN
bptjm-64	30	53	.	.	PUNCT
bptjm-64	31	1	they	they	PRON
bptjm-64	31	2	transition	transition	VERB
bptjm-64	31	3	into	into	ADP
bptjm-64	31	4	cancer	cancer	NOUN
bptjm-64	31	5	-	-	PUNCT
bptjm-64	31	6	associated	associate	VERB
bptjm-64	31	7	�	�	NOUN
bptjm-64	31	8	broblasts	broblast	NOUN
bptjm-64	31	9	(	(	PUNCT
bptjm-64	31	10	cafs	cafs	NOUN
bptjm-64	31	11	)	)	PUNCT
bptjm-64	31	12	,	,	PUNCT
bptjm-64	31	13	facilitating	facilitate	VERB
bptjm-64	31	14	communication	communication	NOUN
bptjm-64	31	15	between	between	ADP
bptjm-64	31	16	tumor	tumor	NOUN
bptjm-64	31	17	cells	cell	NOUN
bptjm-64	31	18	and	and	CCONJ
bptjm-64	31	19	the	the	DET
bptjm-64	31	20	tumor	tumor	NOUN
bptjm-64	31	21	microenvironment	microenvironment	NOUN
bptjm-64	31	22	(	(	PUNCT
bptjm-64	31	23	tme).1	tme).1	SYM
bptjm-64	31	24	this	this	DET
bptjm-64	31	25	interaction	interaction	NOUN
bptjm-64	31	26	often	often	ADV
bptjm-64	31	27	leads	lead	VERB
bptjm-64	31	28	to	to	ADP
bptjm-64	31	29	the	the	DET
bptjm-64	31	30	disruption	disruption	NOUN
bptjm-64	31	31	of	of	ADP
bptjm-64	31	32	cell	cell	NOUN
bptjm-64	31	33	connections	connection	NOUN
bptjm-64	31	34	and	and	CCONJ
bptjm-64	31	35	detachment	detachment	NOUN
bptjm-64	31	36	.	.	PUNCT
bptjm-64	32	1	cafs	cafs	PROPN
bptjm-64	32	2	can	can	AUX
bptjm-64	32	3	derive	derive	VERB
bptjm-64	32	4	from	from	ADP
bptjm-64	32	5	various	various	ADJ
bptjm-64	32	6	immune	immune	ADJ
bptjm-64	32	7	cells	cell	NOUN
bptjm-64	32	8	,	,	PUNCT
bptjm-64	32	9	but	but	CCONJ
bptjm-64	32	10	within	within	ADP
bptjm-64	32	11	the	the	DET
bptjm-64	32	12	tme	tme	NOUN
bptjm-64	32	13	,	,	PUNCT
bptjm-64	32	14	they	they	PRON
bptjm-64	32	15	become	become	VERB
bptjm-64	32	16	berkeley	berkeley	PROPN
bptjm-64	32	17	pharma	pharma	PROPN
bptjm-64	32	18	tech	tech	NOUN
bptjm-64	32	19	journal	journal	NOUN
bptjm-64	32	20	of	of	ADP
bptjm-64	32	21	medicine	medicine	NOUN
bptjm-64	32	22	|	|	ADV
bptjm-64	32	23	116	116	NUM
bptjm-64	32	24	signi	signi	ADJ
bptjm-64	32	25	�	�	NOUN
bptjm-64	32	26	cant	cant	VERB
bptjm-64	32	27	producers	producer	NOUN
bptjm-64	32	28	of	of	ADP
bptjm-64	32	29	extracellular	extracellular	ADJ
bptjm-64	32	30	matrix	matrix	NOUN
bptjm-64	32	31	(	(	PUNCT
bptjm-64	32	32	ecm	ecm	PROPN
bptjm-64	32	33	)	)	PUNCT
bptjm-64	32	34	,	,	PUNCT
bptjm-64	32	35	tumor	tumor	NOUN
bptjm-64	32	36	growth	growth	NOUN
bptjm-64	32	37	factors	factor	NOUN
bptjm-64	32	38	,	,	PUNCT
bptjm-64	32	39	cytokines	cytokine	NOUN
bptjm-64	32	40	,	,	PUNCT
bptjm-64	32	41	and	and	CCONJ
bptjm-64	32	42	other	other	ADJ
bptjm-64	32	43	essential	essential	ADJ
bptjm-64	32	44	components	component	NOUN
bptjm-64	32	45	.	.	PUNCT
bptjm-64	33	1	each	each	DET
bptjm-64	33	2	stromal	stromal	ADJ
bptjm-64	33	3	cell	cell	NOUN
bptjm-64	33	4	type	type	NOUN
bptjm-64	33	5	contributes	contribute	VERB
bptjm-64	33	6	uniquely	uniquely	ADV
bptjm-64	33	7	to	to	ADP
bptjm-64	33	8	the	the	DET
bptjm-64	33	9	tme	tme	NOUN
bptjm-64	33	10	,	,	PUNCT
bptjm-64	33	11	and	and	CCONJ
bptjm-64	33	12	targeting	target	VERB
bptjm-64	33	13	their	their	PRON
bptjm-64	33	14	speci	speci	ADJ
bptjm-64	33	15	�	�	PROPN
bptjm-64	33	16	c	c	PROPN
bptjm-64	33	17	functions	function	NOUN
bptjm-64	33	18	presents	present	VERB
bptjm-64	33	19	an	an	DET
bptjm-64	33	20	opportunity	opportunity	NOUN
bptjm-64	33	21	for	for	ADP
bptjm-64	33	22	novel	novel	ADJ
bptjm-64	33	23	immunotherapeutic	immunotherapeutic	ADJ
bptjm-64	33	24	approaches.1	approaches.1	ADP
bptjm-64	33	25	the	the	DET
bptjm-64	33	26	immune	immune	ADJ
bptjm-64	33	27	response	response	NOUN
bptjm-64	33	28	involves	involve	VERB
bptjm-64	33	29	numerous	numerous	ADJ
bptjm-64	33	30	intricate	intricate	ADJ
bptjm-64	33	31	processes	process	NOUN
bptjm-64	33	32	,	,	PUNCT
bptjm-64	33	33	among	among	ADP
bptjm-64	33	34	which	which	PRON
bptjm-64	33	35	angiogenesis	angiogenesis	NOUN
bptjm-64	33	36	stands	stand	VERB
bptjm-64	33	37	out	out	ADP
bptjm-64	33	38	—	—	PUNCT
bptjm-64	33	39	a	a	DET
bptjm-64	33	40	phenomenon	phenomenon	NOUN
bptjm-64	33	41	where	where	SCONJ
bptjm-64	33	42	endothelial	endothelial	ADJ
bptjm-64	33	43	cells	cell	NOUN
bptjm-64	33	44	proliferate	proliferate	VERB
bptjm-64	33	45	and	and	CCONJ
bptjm-64	33	46	migrate	migrate	VERB
bptjm-64	33	47	,	,	PUNCT
bptjm-64	33	48	forming	form	VERB
bptjm-64	33	49	new	new	ADJ
bptjm-64	33	50	blood	blood	NOUN
bptjm-64	33	51	vessels.11	vessels.11	NOUN
bptjm-64	33	52	this	this	DET
bptjm-64	33	53	process	process	NOUN
bptjm-64	33	54	is	be	AUX
bptjm-64	33	55	pivotal	pivotal	ADJ
bptjm-64	33	56	as	as	SCONJ
bptjm-64	33	57	it	it	PRON
bptjm-64	33	58	grants	grant	VERB
bptjm-64	33	59	tumors	tumor	NOUN
bptjm-64	33	60	the	the	DET
bptjm-64	33	61	capability	capability	NOUN
bptjm-64	33	62	to	to	PART
bptjm-64	33	63	metastasize	metastasize	VERB
bptjm-64	33	64	,	,	PUNCT
bptjm-64	33	65	spreading	spread	VERB
bptjm-64	33	66	to	to	ADP
bptjm-64	33	67	other	other	ADJ
bptjm-64	33	68	locations	location	NOUN
bptjm-64	33	69	within	within	ADP
bptjm-64	33	70	the	the	DET
bptjm-64	33	71	body	body	NOUN
bptjm-64	33	72	.	.	PUNCT
bptjm-64	34	1	conversely	conversely	ADV
bptjm-64	34	2	,	,	PUNCT
bptjm-64	34	3	inhibiting	inhibit	VERB
bptjm-64	34	4	angiogenesis	angiogenesis	NOUN
bptjm-64	34	5	can	can	AUX
bptjm-64	34	6	e	e	AUX
bptjm-64	34	7	�	�	NOUN
bptjm-64	34	8	ectively	ectively	ADV
bptjm-64	34	9	curtail	curtail	VERB
bptjm-64	34	10	tumor	tumor	NOUN
bptjm-64	34	11	growth	growth	NOUN
bptjm-64	34	12	and	and	CCONJ
bptjm-64	34	13	metastasis.11	metastasis.11	NOUN
bptjm-64	34	14	for	for	ADP
bptjm-64	34	15	instance	instance	NOUN
bptjm-64	34	16	,	,	PUNCT
bptjm-64	34	17	research	research	NOUN
bptjm-64	34	18	conducted	conduct	VERB
bptjm-64	34	19	by	by	ADP
bptjm-64	34	20	chen	chen	PROPN
bptjm-64	34	21	et	et	PROPN
bptjm-64	34	22	al	al	PROPN
bptjm-64	34	23	.	.	PROPN
bptjm-64	34	24	demonstrates	demonstrate	VERB
bptjm-64	34	25	that	that	SCONJ
bptjm-64	34	26	the	the	DET
bptjm-64	34	27	administration	administration	NOUN
bptjm-64	34	28	of	of	ADP
bptjm-64	34	29	anti	anti	ADJ
bptjm-64	34	30	-	-	ADJ
bptjm-64	34	31	malarial	malarial	ADJ
bptjm-64	34	32	drugs	drug	NOUN
bptjm-64	34	33	like	like	ADP
bptjm-64	34	34	dihydroartemisinin	dihydroartemisinin	NOUN
bptjm-64	34	35	and	and	CCONJ
bptjm-64	34	36	artesunate	artesunate	NOUN
bptjm-64	34	37	resulted	result	VERB
bptjm-64	34	38	in	in	ADP
bptjm-64	34	39	a	a	DET
bptjm-64	34	40	reduction	reduction	NOUN
bptjm-64	34	41	in	in	ADP
bptjm-64	34	42	the	the	DET
bptjm-64	34	43	size	size	NOUN
bptjm-64	34	44	of	of	ADP
bptjm-64	34	45	cell	cell	NOUN
bptjm-64	34	46	lines	line	NOUN
bptjm-64	34	47	.	.	PUNCT
bptjm-64	35	1	these	these	DET
bptjm-64	35	2	drugs	drug	NOUN
bptjm-64	35	3	were	be	AUX
bptjm-64	35	4	found	find	VERB
bptjm-64	35	5	to	to	PART
bptjm-64	35	6	hinder	hinder	VERB
bptjm-64	35	7	the	the	DET
bptjm-64	35	8	growth	growth	NOUN
bptjm-64	35	9	factors	factor	NOUN
bptjm-64	35	10	crucial	crucial	ADJ
bptjm-64	35	11	for	for	ADP
bptjm-64	35	12	cancer	cancer	NOUN
bptjm-64	35	13	cell	cell	NOUN
bptjm-64	35	14	proliferation	proliferation	NOUN
bptjm-64	35	15	,	,	PUNCT
bptjm-64	35	16	thereby	thereby	ADV
bptjm-64	35	17	impeding	impede	VERB
bptjm-64	35	18	angiogenesis.11	angiogenesis.11	ADJ
bptjm-64	35	19	anti	anti	ADJ
bptjm-64	35	20	-	-	ADJ
bptjm-64	35	21	angiogenic	angiogenic	ADJ
bptjm-64	35	22	(	(	PUNCT
bptjm-64	35	23	aa	aa	NOUN
bptjm-64	35	24	)	)	PUNCT
bptjm-64	35	25	therapy	therapy	NOUN
bptjm-64	35	26	plays	play	VERB
bptjm-64	35	27	a	a	DET
bptjm-64	35	28	signi	signi	ADJ
bptjm-64	35	29	�	�	NOUN
bptjm-64	35	30	cant	cant	NOUN
bptjm-64	35	31	role	role	NOUN
bptjm-64	35	32	in	in	ADP
bptjm-64	35	33	remodeling	remodel	VERB
bptjm-64	35	34	the	the	DET
bptjm-64	35	35	extracellular	extracellular	ADJ
bptjm-64	35	36	matrix	matrix	NOUN
bptjm-64	35	37	(	(	PUNCT
bptjm-64	35	38	ecm	ecm	PROPN
bptjm-64	35	39	)	)	PUNCT
bptjm-64	35	40	,	,	PUNCT
bptjm-64	35	41	altering	alter	VERB
bptjm-64	35	42	the	the	DET
bptjm-64	35	43	distribution	distribution	NOUN
bptjm-64	35	44	of	of	ADP
bptjm-64	35	45	cell	cell	NOUN
bptjm-64	35	46	types	type	NOUN
bptjm-64	35	47	and	and	CCONJ
bptjm-64	35	48	populations.12	populations.12	NOUN
bptjm-64	35	49	this	this	DET
bptjm-64	35	50	therapy	therapy	NOUN
bptjm-64	35	51	redistributes	redistribute	VERB
bptjm-64	35	52	pericyte	pericyte	NOUN
bptjm-64	35	53	proteins	protein	NOUN
bptjm-64	35	54	along	along	ADP
bptjm-64	35	55	blood	blood	NOUN
bptjm-64	35	56	vessels	vessel	NOUN
bptjm-64	35	57	,	,	PUNCT
bptjm-64	35	58	increasing	increase	VERB
bptjm-64	35	59	coverage	coverage	NOUN
bptjm-64	35	60	and	and	CCONJ
bptjm-64	35	61	eliciting	elicit	VERB
bptjm-64	35	62	a	a	DET
bptjm-64	35	63	pro	pro	ADJ
bptjm-64	35	64	-	-	ADJ
bptjm-64	35	65	aggressive	aggressive	ADJ
bptjm-64	35	66	tumor	tumor	NOUN
bptjm-64	35	67	response	response	NOUN
bptjm-64	35	68	.	.	PUNCT
bptjm-64	36	1	notably	notably	ADV
bptjm-64	36	2	,	,	PUNCT
bptjm-64	36	3	glycosylation	glycosylation	NOUN
bptjm-64	36	4	of	of	ADP
bptjm-64	36	5	these	these	DET
bptjm-64	36	6	proteins	protein	NOUN
bptjm-64	36	7	is	be	AUX
bptjm-64	36	8	speculated	speculate	VERB
bptjm-64	36	9	to	to	PART
bptjm-64	36	10	contribute	contribute	VERB
bptjm-64	36	11	to	to	ADP
bptjm-64	36	12	malignant	malignant	ADJ
bptjm-64	36	13	resistance	resistance	NOUN
bptjm-64	36	14	to	to	ADP
bptjm-64	36	15	aa	aa	PROPN
bptjm-64	36	16	therapy.12	therapy.12	NOUN
bptjm-64	36	17	however	however	ADV
bptjm-64	36	18	,	,	PUNCT
bptjm-64	36	19	a	a	DET
bptjm-64	36	20	complication	complication	NOUN
bptjm-64	36	21	arises	arise	VERB
bptjm-64	36	22	as	as	SCONJ
bptjm-64	36	23	resistance	resistance	NOUN
bptjm-64	36	24	can	can	AUX
bptjm-64	36	25	develop	develop	VERB
bptjm-64	36	26	post	post	ADJ
bptjm-64	36	27	-	-	ADJ
bptjm-64	36	28	aa	aa	ADJ
bptjm-64	36	29	treatment	treatment	NOUN
bptjm-64	36	30	,	,	PUNCT
bptjm-64	36	31	fostering	foster	VERB
bptjm-64	36	32	tumor	tumor	NOUN
bptjm-64	36	33	cell	cell	NOUN
bptjm-64	36	34	migration	migration	NOUN
bptjm-64	36	35	and	and	CCONJ
bptjm-64	36	36	invasion	invasion	NOUN
bptjm-64	36	37	.	.	PUNCT
bptjm-64	37	1	tumor	tumor	NOUN
bptjm-64	37	2	cell	cell	NOUN
bptjm-64	37	3	receptors	receptor	NOUN
bptjm-64	37	4	possess	possess	VERB
bptjm-64	37	5	mechanisms	mechanism	NOUN
bptjm-64	37	6	to	to	PART
bptjm-64	37	7	detect	detect	VERB
bptjm-64	37	8	aa	aa	ADV
bptjm-64	37	9	-	-	PUNCT
bptjm-64	37	10	induced	induce	VERB
bptjm-64	37	11	alterations	alteration	NOUN
bptjm-64	37	12	in	in	ADP
bptjm-64	37	13	their	their	PRON
bptjm-64	37	14	environment	environment	NOUN
bptjm-64	37	15	,	,	PUNCT
bptjm-64	37	16	prompting	prompt	VERB
bptjm-64	37	17	a	a	DET
bptjm-64	37	18	remodeling	remodeling	NOUN
bptjm-64	37	19	of	of	ADP
bptjm-64	37	20	the	the	DET
bptjm-64	37	21	entire	entire	ADJ
bptjm-64	37	22	tumor	tumor	NOUN
bptjm-64	37	23	microenvironment	microenvironment	NOUN
bptjm-64	37	24	(	(	PUNCT
bptjm-64	37	25	tme	tme	NOUN
bptjm-64	37	26	)	)	PUNCT
bptjm-64	37	27	to	to	PART
bptjm-64	37	28	facilitate	facilitate	VERB
bptjm-64	37	29	tumor	tumor	NOUN
bptjm-64	37	30	growth	growth	NOUN
bptjm-64	37	31	once	once	ADV
bptjm-64	37	32	more.12	more.12	VERB
bptjm-64	37	33	3	3	NUM
bptjm-64	37	34	.	.	PUNCT
bptjm-64	38	1	t	t	NOUN
bptjm-64	38	2	cell	cell	NOUN
bptjm-64	38	3	based	base	VERB
bptjm-64	38	4	immunotherapy	immunotherapy	NOUN
bptjm-64	38	5	this	this	DET
bptjm-64	38	6	section	section	NOUN
bptjm-64	38	7	of	of	ADP
bptjm-64	38	8	the	the	DET
bptjm-64	38	9	review	review	NOUN
bptjm-64	38	10	will	will	AUX
bptjm-64	38	11	delve	delve	VERB
bptjm-64	38	12	into	into	ADP
bptjm-64	38	13	several	several	ADJ
bptjm-64	38	14	key	key	ADJ
bptjm-64	38	15	surface	surface	NOUN
bptjm-64	38	16	cell	cell	NOUN
bptjm-64	38	17	receptors	receptor	NOUN
bptjm-64	38	18	found	find	VERB
bptjm-64	38	19	on	on	ADP
bptjm-64	38	20	endothelial	endothelial	ADJ
bptjm-64	38	21	cells	cell	NOUN
bptjm-64	38	22	,	,	PUNCT
bptjm-64	38	23	tumor	tumor	NOUN
bptjm-64	38	24	cells	cell	NOUN
bptjm-64	38	25	,	,	PUNCT
bptjm-64	38	26	and	and	CCONJ
bptjm-64	38	27	t	t	NOUN
bptjm-64	38	28	-	-	PUNCT
bptjm-64	38	29	cells	cell	NOUN
bptjm-64	38	30	.	.	PUNCT
bptjm-64	39	1	it	it	PRON
bptjm-64	39	2	will	will	AUX
bptjm-64	39	3	explore	explore	VERB
bptjm-64	39	4	their	their	PRON
bptjm-64	39	5	roles	role	NOUN
bptjm-64	39	6	in	in	ADP
bptjm-64	39	7	promoting	promote	VERB
bptjm-64	39	8	tumor	tumor	NOUN
bptjm-64	39	9	growth	growth	NOUN
bptjm-64	39	10	,	,	PUNCT
bptjm-64	39	11	strategies	strategy	NOUN
bptjm-64	39	12	to	to	PART
bptjm-64	39	13	overcome	overcome	VERB
bptjm-64	39	14	resistance	resistance	NOUN
bptjm-64	39	15	,	,	PUNCT
bptjm-64	39	16	and	and	CCONJ
bptjm-64	39	17	the	the	DET
bptjm-64	39	18	berkeley	berkeley	PROPN
bptjm-64	39	19	pharma	pharma	PROPN
bptjm-64	39	20	tech	tech	NOUN
bptjm-64	39	21	journal	journal	NOUN
bptjm-64	39	22	of	of	ADP
bptjm-64	39	23	medicine	medicine	NOUN
bptjm-64	39	24	|	|	ADV
bptjm-64	39	25	117	117	NUM
bptjm-64	39	26	underlying	underlying	ADJ
bptjm-64	39	27	mechanisms	mechanism	NOUN
bptjm-64	39	28	of	of	ADP
bptjm-64	39	29	resistance	resistance	NOUN
bptjm-64	39	30	.	.	PUNCT
bptjm-64	40	1	emphasis	emphasis	NOUN
bptjm-64	40	2	will	will	AUX
bptjm-64	40	3	also	also	ADV
bptjm-64	40	4	be	be	AUX
bptjm-64	40	5	placed	place	VERB
bptjm-64	40	6	on	on	ADP
bptjm-64	40	7	the	the	DET
bptjm-64	40	8	critical	critical	ADJ
bptjm-64	40	9	functions	function	NOUN
bptjm-64	40	10	of	of	ADP
bptjm-64	40	11	in	in	ADP
bptjm-64	40	12	�	�	PROPN
bptjm-64	40	13	ltrating	ltrate	VERB
bptjm-64	40	14	tumor	tumor	NOUN
bptjm-64	40	15	lymphocytes	lymphocyte	NOUN
bptjm-64	40	16	and	and	CCONJ
bptjm-64	40	17	cytotoxic	cytotoxic	ADJ
bptjm-64	40	18	t	t	NOUN
bptjm-64	40	19	cells	cell	NOUN
bptjm-64	40	20	.	.	PUNCT
bptjm-64	41	1	within	within	ADP
bptjm-64	41	2	the	the	DET
bptjm-64	41	3	tumor	tumor	NOUN
bptjm-64	41	4	microenvironment	microenvironment	NOUN
bptjm-64	41	5	(	(	PUNCT
bptjm-64	41	6	tme	tme	PROPN
bptjm-64	41	7	)	)	PUNCT
bptjm-64	41	8	,	,	PUNCT
bptjm-64	41	9	various	various	ADJ
bptjm-64	41	10	surface	surface	NOUN
bptjm-64	41	11	cell	cell	NOUN
bptjm-64	41	12	receptors	receptor	NOUN
bptjm-64	41	13	recognize	recognize	VERB
bptjm-64	41	14	speci	speci	ADJ
bptjm-64	41	15	�	�	PROPN
bptjm-64	41	16	c	c	NOUN
bptjm-64	41	17	antigens	antigen	NOUN
bptjm-64	41	18	,	,	PUNCT
bptjm-64	41	19	initiating	initiate	VERB
bptjm-64	41	20	signaling	signal	VERB
bptjm-64	41	21	cascades	cascade	NOUN
bptjm-64	41	22	that	that	PRON
bptjm-64	41	23	ultimately	ultimately	ADV
bptjm-64	41	24	impact	impact	VERB
bptjm-64	41	25	downstream	downstream	ADJ
bptjm-64	41	26	events	event	NOUN
bptjm-64	41	27	.	.	PUNCT
bptjm-64	42	1	these	these	DET
bptjm-64	42	2	cascades	cascade	NOUN
bptjm-64	42	3	often	often	ADV
bptjm-64	42	4	lead	lead	VERB
bptjm-64	42	5	to	to	ADP
bptjm-64	42	6	the	the	DET
bptjm-64	42	7	inactivation	inactivation	NOUN
bptjm-64	42	8	or	or	CCONJ
bptjm-64	42	9	impairment	impairment	NOUN
bptjm-64	42	10	of	of	ADP
bptjm-64	42	11	e	e	PROPN
bptjm-64	42	12	�	�	PROPN
bptjm-64	42	13	ective	ective	ADJ
bptjm-64	42	14	t	t	PROPN
bptjm-64	42	15	-	-	PUNCT
bptjm-64	42	16	cells	cell	NOUN
bptjm-64	42	17	,	,	PUNCT
bptjm-64	42	18	which	which	PRON
bptjm-64	42	19	are	be	AUX
bptjm-64	42	20	typically	typically	ADV
bptjm-64	42	21	responsible	responsible	ADJ
bptjm-64	42	22	for	for	ADP
bptjm-64	42	23	targeting	target	VERB
bptjm-64	42	24	and	and	CCONJ
bptjm-64	42	25	eliminating	eliminate	VERB
bptjm-64	42	26	tumor	tumor	NOUN
bptjm-64	42	27	cells	cell	NOUN
bptjm-64	42	28	.	.	PUNCT
bptjm-64	43	1	the	the	DET
bptjm-64	43	2	tme	tme	PROPN
bptjm-64	43	3	,	,	PUNCT
bptjm-64	43	4	being	be	AUX
bptjm-64	43	5	highly	highly	ADV
bptjm-64	43	6	adaptable	adaptable	ADJ
bptjm-64	43	7	,	,	PUNCT
bptjm-64	43	8	fosters	foster	VERB
bptjm-64	43	9	conditions	condition	NOUN
bptjm-64	43	10	conducive	conducive	ADJ
bptjm-64	43	11	to	to	ADP
bptjm-64	43	12	tumor	tumor	NOUN
bptjm-64	43	13	cell	cell	NOUN
bptjm-64	43	14	growth	growth	NOUN
bptjm-64	43	15	,	,	PUNCT
bptjm-64	43	16	proliferation	proliferation	NOUN
bptjm-64	43	17	,	,	PUNCT
bptjm-64	43	18	and	and	CCONJ
bptjm-64	43	19	survival.13	survival.13	NOUN
bptjm-64	43	20	several	several	ADJ
bptjm-64	43	21	immune	immune	ADJ
bptjm-64	43	22	response	response	NOUN
bptjm-64	43	23	cells	cell	NOUN
bptjm-64	43	24	contribute	contribute	VERB
bptjm-64	43	25	to	to	ADP
bptjm-64	43	26	immune	immune	ADJ
bptjm-64	43	27	resistance	resistance	NOUN
bptjm-64	43	28	,	,	PUNCT
bptjm-64	43	29	including	include	VERB
bptjm-64	43	30	myeloid	myeloid	NOUN
bptjm-64	43	31	-	-	PUNCT
bptjm-64	43	32	derived	derive	VERB
bptjm-64	43	33	suppressor	suppressor	NOUN
bptjm-64	43	34	cells	cell	NOUN
bptjm-64	43	35	(	(	PUNCT
bptjm-64	43	36	mdscs	mdsc	NOUN
bptjm-64	43	37	)	)	PUNCT
bptjm-64	43	38	,	,	PUNCT
bptjm-64	43	39	regulatory	regulatory	ADJ
bptjm-64	43	40	t	t	NOUN
bptjm-64	43	41	cells	cell	NOUN
bptjm-64	43	42	(	(	PUNCT
bptjm-64	43	43	tregs	treg	NOUN
bptjm-64	43	44	)	)	PUNCT
bptjm-64	43	45	,	,	PUNCT
bptjm-64	43	46	tumor	tumor	NOUN
bptjm-64	43	47	-	-	PUNCT
bptjm-64	43	48	associated	associate	VERB
bptjm-64	43	49	macrophages	macrophage	NOUN
bptjm-64	43	50	(	(	PUNCT
bptjm-64	43	51	tams	tam	NOUN
bptjm-64	43	52	)	)	PUNCT
bptjm-64	43	53	,	,	PUNCT
bptjm-64	43	54	tumor	tumor	NOUN
bptjm-64	43	55	-	-	PUNCT
bptjm-64	43	56	associated	associate	VERB
bptjm-64	43	57	neutrophils	neutrophil	NOUN
bptjm-64	43	58	(	(	PUNCT
bptjm-64	43	59	tans	tan	NOUN
bptjm-64	43	60	)	)	PUNCT
bptjm-64	43	61	,	,	PUNCT
bptjm-64	43	62	and	and	CCONJ
bptjm-64	43	63	endothelial	endothelial	ADJ
bptjm-64	43	64	cells	cell	NOUN
bptjm-64	43	65	.	.	PUNCT
bptjm-64	44	1	the	the	DET
bptjm-64	44	2	secretion	secretion	NOUN
bptjm-64	44	3	of	of	ADP
bptjm-64	44	4	negative	negative	ADJ
bptjm-64	44	5	regulatory	regulatory	ADJ
bptjm-64	44	6	factors	factor	NOUN
bptjm-64	44	7	by	by	ADP
bptjm-64	44	8	these	these	DET
bptjm-64	44	9	cells	cell	NOUN
bptjm-64	44	10	can	can	AUX
bptjm-64	44	11	induce	induce	VERB
bptjm-64	44	12	t	t	NOUN
bptjm-64	44	13	-	-	PUNCT
bptjm-64	44	14	cell	cell	NOUN
bptjm-64	44	15	exhaustion	exhaustion	NOUN
bptjm-64	44	16	,	,	PUNCT
bptjm-64	44	17	dysfunction	dysfunction	NOUN
bptjm-64	44	18	,	,	PUNCT
bptjm-64	44	19	and	and	CCONJ
bptjm-64	44	20	apoptosis.13	apoptosis.13	PROPN
bptjm-64	44	21	figure	figure	NOUN
bptjm-64	44	22	2	2	NUM
bptjm-64	44	23	:	:	PUNCT
bptjm-64	44	24	a.	a.	NOUN
bptjm-64	44	25	vascular	vascular	ADJ
bptjm-64	44	26	endothelial	endothelial	ADJ
bptjm-64	44	27	growth	growth	NOUN
bptjm-64	44	28	factor	factor	NOUN
bptjm-64	44	29	-	-	PUNCT
bptjm-64	44	30	a	a	PRON
bptjm-64	44	31	(	(	PUNCT
bptjm-64	44	32	vegf	vegf	NOUN
bptjm-64	44	33	-	-	PUNCT
bptjm-64	44	34	a	a	NOUN
bptjm-64	44	35	)	)	PUNCT
bptjm-64	44	36	binds	bind	VERB
bptjm-64	44	37	to	to	PART
bptjm-64	44	38	vascular	vascular	VERB
bptjm-64	44	39	endothelial	endothelial	ADJ
bptjm-64	44	40	growth	growth	NOUN
bptjm-64	44	41	factor	factor	NOUN
bptjm-64	44	42	receptors	receptor	NOUN
bptjm-64	44	43	(	(	PUNCT
bptjm-64	44	44	vegfrs	vegfrs	NOUN
bptjm-64	44	45	)	)	PUNCT
bptjm-64	44	46	situated	situate	VERB
bptjm-64	44	47	on	on	ADP
bptjm-64	44	48	endothelial	endothelial	ADJ
bptjm-64	44	49	cell	cell	NOUN
bptjm-64	44	50	surfaces	surface	NOUN
bptjm-64	44	51	,	,	PUNCT
bptjm-64	44	52	initiating	initiate	VERB
bptjm-64	44	53	a	a	DET
bptjm-64	44	54	series	series	NOUN
bptjm-64	44	55	of	of	ADP
bptjm-64	44	56	reactions	reaction	NOUN
bptjm-64	44	57	that	that	PRON
bptjm-64	44	58	stimulate	stimulate	VERB
bptjm-64	44	59	angiogenesis	angiogenesis	NOUN
bptjm-64	44	60	.	.	PUNCT
bptjm-64	45	1	b.	b.	PROPN
bptjm-64	46	1	the	the	DET
bptjm-64	46	2	interplay	interplay	NOUN
bptjm-64	46	3	between	between	ADP
bptjm-64	46	4	proteins	protein	NOUN
bptjm-64	46	5	located	locate	VERB
bptjm-64	46	6	on	on	ADP
bptjm-64	46	7	t	t	PROPN
bptjm-64	46	8	cell	cell	NOUN
bptjm-64	46	9	surfaces	surface	NOUN
bptjm-64	46	10	and	and	CCONJ
bptjm-64	46	11	their	their	PRON
bptjm-64	46	12	corresponding	corresponding	ADJ
bptjm-64	46	13	ligand	ligand	NOUN
bptjm-64	46	14	surface	surface	NOUN
bptjm-64	46	15	cell	cell	NOUN
bptjm-64	46	16	receptors	receptor	NOUN
bptjm-64	46	17	on	on	ADP
bptjm-64	46	18	tumor	tumor	NOUN
bptjm-64	46	19	cells	cell	NOUN
bptjm-64	46	20	contributes	contribute	VERB
bptjm-64	46	21	to	to	ADP
bptjm-64	46	22	t	t	NOUN
bptjm-64	46	23	cell	cell	NOUN
bptjm-64	46	24	exhaustion	exhaustion	NOUN
bptjm-64	46	25	.	.	PUNCT
bptjm-64	47	1	berkeley	berkeley	PROPN
bptjm-64	47	2	pharma	pharma	PROPN
bptjm-64	47	3	tech	tech	PROPN
bptjm-64	47	4	journal	journal	NOUN
bptjm-64	47	5	of	of	ADP
bptjm-64	47	6	medicine	medicine	NOUN
bptjm-64	47	7	|	|	ADV
bptjm-64	47	8	118	118	NUM
bptjm-64	47	9	one	one	NUM
bptjm-64	47	10	e	e	NOUN
bptjm-64	47	11	�	�	NOUN
bptjm-64	47	12	ective	ective	ADJ
bptjm-64	47	13	therapeutic	therapeutic	ADJ
bptjm-64	47	14	approach	approach	NOUN
bptjm-64	47	15	,	,	PUNCT
bptjm-64	47	16	immune	immune	ADJ
bptjm-64	47	17	checkpoint	checkpoint	NOUN
bptjm-64	47	18	inhibition	inhibition	NOUN
bptjm-64	47	19	,	,	PUNCT
bptjm-64	47	20	has	have	AUX
bptjm-64	47	21	demonstrated	demonstrate	VERB
bptjm-64	47	22	success	success	NOUN
bptjm-64	47	23	in	in	ADP
bptjm-64	47	24	rejuvenating	rejuvenate	VERB
bptjm-64	47	25	the	the	DET
bptjm-64	47	26	cytotoxic	cytotoxic	ADJ
bptjm-64	47	27	function	function	NOUN
bptjm-64	47	28	of	of	ADP
bptjm-64	47	29	ctls	ctls	PROPN
bptjm-64	47	30	and	and	CCONJ
bptjm-64	47	31	t	t	NOUN
bptjm-64	47	32	-	-	PUNCT
bptjm-64	47	33	cells	cell	NOUN
bptjm-64	47	34	.	.	PUNCT
bptjm-64	48	1	this	this	DET
bptjm-64	48	2	therapy	therapy	NOUN
bptjm-64	48	3	works	work	VERB
bptjm-64	48	4	by	by	ADP
bptjm-64	48	5	alleviating	alleviate	VERB
bptjm-64	48	6	the	the	DET
bptjm-64	48	7	suppression	suppression	NOUN
bptjm-64	48	8	of	of	ADP
bptjm-64	48	9	antitumor	antitumor	PROPN
bptjm-64	48	10	immunity	immunity	NOUN
bptjm-64	48	11	,	,	PUNCT
bptjm-64	48	12	freeing	free	VERB
bptjm-64	48	13	ctls	ctls	NOUN
bptjm-64	48	14	from	from	ADP
bptjm-64	48	15	exhaustion.13	exhaustion.13	PROPN
bptjm-64	48	16	the	the	DET
bptjm-64	48	17	fda	fda	PROPN
bptjm-64	48	18	has	have	AUX
bptjm-64	48	19	approved	approve	VERB
bptjm-64	48	20	antibodies	antibody	NOUN
bptjm-64	48	21	targeting	target	VERB
bptjm-64	48	22	programmed	program	VERB
bptjm-64	48	23	cell	cell	NOUN
bptjm-64	48	24	death	death	NOUN
bptjm-64	48	25	1	1	NUM
bptjm-64	48	26	(	(	PUNCT
bptjm-64	48	27	pd-1	pd-1	NOUN
bptjm-64	48	28	/	/	SYM
bptjm-64	48	29	pd	pd	NOUN
bptjm-64	48	30	-	-	PUNCT
bptjm-64	48	31	l1	l1	NOUN
bptjm-64	48	32	)	)	PUNCT
bptjm-64	48	33	and	and	CCONJ
bptjm-64	48	34	cytotoxic	cytotoxic	ADJ
bptjm-64	48	35	t	t	NOUN
bptjm-64	48	36	lymphocyte	lymphocyte	NOUN
bptjm-64	48	37	-	-	PUNCT
bptjm-64	48	38	associated	associate	VERB
bptjm-64	48	39	protein	protein	NOUN
bptjm-64	48	40	4	4	NUM
bptjm-64	48	41	(	(	PUNCT
bptjm-64	48	42	ctla-4	ctla-4	X
bptjm-64	48	43	)	)	PUNCT
bptjm-64	48	44	for	for	ADP
bptjm-64	48	45	treating	treat	VERB
bptjm-64	48	46	various	various	ADJ
bptjm-64	48	47	cancers	cancer	NOUN
bptjm-64	48	48	.	.	PUNCT
bptjm-64	49	1	additionally	additionally	ADV
bptjm-64	49	2	,	,	PUNCT
bptjm-64	49	3	ongoing	ongoing	ADJ
bptjm-64	49	4	clinical	clinical	ADJ
bptjm-64	49	5	research	research	NOUN
bptjm-64	49	6	is	be	AUX
bptjm-64	49	7	targeting	target	VERB
bptjm-64	49	8	other	other	ADJ
bptjm-64	49	9	immune	immune	ADJ
bptjm-64	49	10	checkpoints	checkpoint	NOUN
bptjm-64	49	11	like	like	ADP
bptjm-64	49	12	lag3	lag3	PROPN
bptjm-64	49	13	,	,	PUNCT
bptjm-64	49	14	cd39	cd39	PROPN
bptjm-64	49	15	,	,	PUNCT
bptjm-64	49	16	cd73	cd73	PROPN
bptjm-64	49	17	,	,	PUNCT
bptjm-64	49	18	and	and	CCONJ
bptjm-64	49	19	cd47	cd47	PROPN
bptjm-64	49	20	,	,	PUNCT
bptjm-64	49	21	all	all	PRON
bptjm-64	49	22	showing	show	VERB
bptjm-64	49	23	promising	promising	ADJ
bptjm-64	49	24	potential	potential	NOUN
bptjm-64	49	25	in	in	ADP
bptjm-64	49	26	advancing	advance	VERB
bptjm-64	49	27	cancer	cancer	NOUN
bptjm-64	49	28	immunotherapy.14	immunotherapy.14	NOUN
bptjm-64	49	29	3.1	3.1	NUM
bptjm-64	49	30	pd-1	pd-1	NOUN
bptjm-64	49	31	/	/	SYM
bptjm-64	49	32	pd	pd	ADJ
bptjm-64	49	33	-	-	PUNCT
bptjm-64	49	34	l1	l1	PROPN
bptjm-64	49	35	immune	immune	ADJ
bptjm-64	49	36	checkpoint	checkpoint	NOUN
bptjm-64	49	37	inhibition	inhibition	NOUN
bptjm-64	49	38	stands	stand	VERB
bptjm-64	49	39	out	out	ADP
bptjm-64	49	40	as	as	ADP
bptjm-64	49	41	an	an	DET
bptjm-64	49	42	e	e	NOUN
bptjm-64	49	43	�	�	NOUN
bptjm-64	49	44	ective	ective	ADJ
bptjm-64	49	45	therapeutic	therapeutic	ADJ
bptjm-64	49	46	approach	approach	NOUN
bptjm-64	49	47	in	in	ADP
bptjm-64	49	48	reviving	revive	VERB
bptjm-64	49	49	the	the	DET
bptjm-64	49	50	cytotoxic	cytotoxic	ADJ
bptjm-64	49	51	capabilities	capability	NOUN
bptjm-64	49	52	of	of	ADP
bptjm-64	49	53	ctls	ctls	PROPN
bptjm-64	49	54	and	and	CCONJ
bptjm-64	49	55	t	t	NOUN
bptjm-64	49	56	-	-	PUNCT
bptjm-64	49	57	cells	cell	NOUN
bptjm-64	49	58	.	.	PUNCT
bptjm-64	50	1	by	by	ADP
bptjm-64	50	2	alleviating	alleviate	VERB
bptjm-64	50	3	the	the	DET
bptjm-64	50	4	exhaustion	exhaustion	NOUN
bptjm-64	50	5	-	-	PUNCT
bptjm-64	50	6	induced	induce	VERB
bptjm-64	50	7	suppression	suppression	NOUN
bptjm-64	50	8	of	of	ADP
bptjm-64	50	9	antitumor	antitumor	PROPN
bptjm-64	50	10	immunity	immunity	NOUN
bptjm-64	50	11	,	,	PUNCT
bptjm-64	50	12	this	this	DET
bptjm-64	50	13	therapy	therapy	NOUN
bptjm-64	50	14	unleashes	unleash	VERB
bptjm-64	50	15	ctls	ctls	NOUN
bptjm-64	50	16	to	to	ADP
bptjm-64	50	17	combat	combat	NOUN
bptjm-64	50	18	tumors.13	tumors.13	NOUN
bptjm-64	50	19	the	the	DET
bptjm-64	50	20	fda	fda	PROPN
bptjm-64	50	21	has	have	AUX
bptjm-64	50	22	approved	approve	VERB
bptjm-64	50	23	the	the	DET
bptjm-64	50	24	use	use	NOUN
bptjm-64	50	25	of	of	ADP
bptjm-64	50	26	antibodies	antibody	NOUN
bptjm-64	50	27	targeting	target	VERB
bptjm-64	50	28	programmed	program	VERB
bptjm-64	50	29	cell	cell	NOUN
bptjm-64	50	30	death	death	NOUN
bptjm-64	50	31	1	1	NUM
bptjm-64	50	32	(	(	PUNCT
bptjm-64	50	33	pd-1	pd-1	NOUN
bptjm-64	50	34	/	/	SYM
bptjm-64	50	35	pd	pd	NOUN
bptjm-64	50	36	-	-	PUNCT
bptjm-64	50	37	l1	l1	NOUN
bptjm-64	50	38	)	)	PUNCT
bptjm-64	50	39	and	and	CCONJ
bptjm-64	50	40	cytotoxic	cytotoxic	ADJ
bptjm-64	50	41	t	t	NOUN
bptjm-64	50	42	lymphocyte	lymphocyte	NOUN
bptjm-64	50	43	-	-	PUNCT
bptjm-64	50	44	associated	associate	VERB
bptjm-64	50	45	protein	protein	NOUN
bptjm-64	50	46	4	4	NUM
bptjm-64	50	47	(	(	PUNCT
bptjm-64	50	48	ctla-4	ctla-4	NOUN
bptjm-64	50	49	)	)	PUNCT
bptjm-64	50	50	as	as	ADP
bptjm-64	50	51	treatments	treatment	NOUN
bptjm-64	50	52	across	across	ADP
bptjm-64	50	53	various	various	ADJ
bptjm-64	50	54	cancer	cancer	NOUN
bptjm-64	50	55	types.13	types.13	ADP
bptjm-64	50	56	numerous	numerous	ADJ
bptjm-64	50	57	other	other	ADJ
bptjm-64	50	58	immune	immune	ADJ
bptjm-64	50	59	checkpoints	checkpoint	NOUN
bptjm-64	50	60	are	be	AUX
bptjm-64	50	61	currently	currently	ADV
bptjm-64	50	62	under	under	ADP
bptjm-64	50	63	investigation	investigation	NOUN
bptjm-64	50	64	in	in	ADP
bptjm-64	50	65	clinical	clinical	ADJ
bptjm-64	50	66	research	research	NOUN
bptjm-64	50	67	,	,	PUNCT
bptjm-64	50	68	including	include	VERB
bptjm-64	50	69	lag3	lag3	PROPN
bptjm-64	50	70	,	,	PUNCT
bptjm-64	50	71	cd39	cd39	PROPN
bptjm-64	50	72	,	,	PUNCT
bptjm-64	50	73	cd73	cd73	PROPN
bptjm-64	50	74	,	,	PUNCT
bptjm-64	50	75	and	and	CCONJ
bptjm-64	50	76	cd47	cd47	PROPN
bptjm-64	50	77	,	,	PUNCT
bptjm-64	50	78	all	all	PRON
bptjm-64	50	79	of	of	ADP
bptjm-64	50	80	which	which	PRON
bptjm-64	50	81	show	show	VERB
bptjm-64	50	82	promising	promising	ADJ
bptjm-64	50	83	potential	potential	NOUN
bptjm-64	50	84	in	in	ADP
bptjm-64	50	85	advancing	advance	VERB
bptjm-64	50	86	the	the	DET
bptjm-64	50	87	landscape	landscape	NOUN
bptjm-64	50	88	of	of	ADP
bptjm-64	50	89	cancer	cancer	NOUN
bptjm-64	50	90	immunotherapy.14	immunotherapy.14	NOUN
bptjm-64	50	91	among	among	ADP
bptjm-64	50	92	these	these	PRON
bptjm-64	50	93	,	,	PUNCT
bptjm-64	50	94	pd-1	pd-1	ADJ
bptjm-64	50	95	is	be	AUX
bptjm-64	50	96	a	a	DET
bptjm-64	50	97	pivotal	pivotal	ADJ
bptjm-64	50	98	protein	protein	NOUN
bptjm-64	50	99	implicated	implicate	VERB
bptjm-64	50	100	in	in	ADP
bptjm-64	50	101	t	t	NOUN
bptjm-64	50	102	cell	cell	NOUN
bptjm-64	50	103	apoptosis	apoptosis	NOUN
bptjm-64	50	104	,	,	PUNCT
bptjm-64	50	105	or	or	CCONJ
bptjm-64	50	106	programmed	program	VERB
bptjm-64	50	107	cell	cell	NOUN
bptjm-64	50	108	death	death	NOUN
bptjm-64	50	109	.	.	PUNCT
bptjm-64	51	1	it	it	PRON
bptjm-64	51	2	is	be	AUX
bptjm-64	51	3	predominantly	predominantly	ADV
bptjm-64	51	4	expressed	express	VERB
bptjm-64	51	5	on	on	ADP
bptjm-64	51	6	the	the	DET
bptjm-64	51	7	surface	surface	NOUN
bptjm-64	51	8	of	of	ADP
bptjm-64	51	9	activated	activated	ADJ
bptjm-64	51	10	immune	immune	ADJ
bptjm-64	51	11	cells	cell	NOUN
bptjm-64	51	12	such	such	ADJ
bptjm-64	51	13	as	as	ADP
bptjm-64	51	14	macrophages	macrophage	NOUN
bptjm-64	51	15	,	,	PUNCT
bptjm-64	51	16	dendritic	dendritic	ADJ
bptjm-64	51	17	cells	cell	NOUN
bptjm-64	51	18	,	,	PUNCT
bptjm-64	51	19	b	b	NOUN
bptjm-64	51	20	cells	cell	NOUN
bptjm-64	51	21	,	,	PUNCT
bptjm-64	51	22	and	and	CCONJ
bptjm-64	51	23	t	t	PROPN
bptjm-64	51	24	cells.14	cells.14	PROPN
bptjm-64	51	25	notably	notably	ADV
bptjm-64	51	26	,	,	PUNCT
bptjm-64	51	27	pd-1	pd-1	VERB
bptjm-64	51	28	expression	expression	NOUN
bptjm-64	51	29	is	be	AUX
bptjm-64	51	30	particularly	particularly	ADV
bptjm-64	51	31	elevated	elevate	VERB
bptjm-64	51	32	on	on	ADP
bptjm-64	51	33	exhausted	exhausted	ADJ
bptjm-64	51	34	t	t	NOUN
bptjm-64	51	35	cells	cell	NOUN
bptjm-64	51	36	,	,	PUNCT
bptjm-64	51	37	where	where	SCONJ
bptjm-64	51	38	it	it	PRON
bptjm-64	51	39	plays	play	VERB
bptjm-64	51	40	a	a	DET
bptjm-64	51	41	role	role	NOUN
bptjm-64	51	42	in	in	ADP
bptjm-64	51	43	inhibiting	inhibit	VERB
bptjm-64	51	44	their	their	PRON
bptjm-64	51	45	normal	normal	ADJ
bptjm-64	51	46	immune	immune	ADJ
bptjm-64	51	47	function	function	NOUN
bptjm-64	51	48	.	.	PUNCT
bptjm-64	52	1	when	when	SCONJ
bptjm-64	52	2	pd-1	pd-1	ADJ
bptjm-64	52	3	interacts	interact	VERB
bptjm-64	52	4	with	with	ADP
bptjm-64	52	5	its	its	PRON
bptjm-64	52	6	ligand	ligand	ADJ
bptjm-64	52	7	receptor	receptor	NOUN
bptjm-64	52	8	,	,	PUNCT
bptjm-64	52	9	pd	pd	PROPN
bptjm-64	52	10	-	-	PUNCT
bptjm-64	52	11	l1	l1	PROPN
bptjm-64	52	12	,	,	PUNCT
bptjm-64	52	13	on	on	ADP
bptjm-64	52	14	tumor	tumor	NOUN
bptjm-64	52	15	cells	cell	NOUN
bptjm-64	52	16	,	,	PUNCT
bptjm-64	52	17	it	it	PRON
bptjm-64	52	18	initiates	initiate	VERB
bptjm-64	52	19	a	a	DET
bptjm-64	52	20	series	series	NOUN
bptjm-64	52	21	of	of	ADP
bptjm-64	52	22	signaling	signal	VERB
bptjm-64	52	23	events	event	NOUN
bptjm-64	52	24	that	that	PRON
bptjm-64	52	25	directly	directly	ADV
bptjm-64	52	26	impede	impede	VERB
bptjm-64	52	27	the	the	DET
bptjm-64	52	28	response	response	NOUN
bptjm-64	52	29	of	of	ADP
bptjm-64	52	30	activated	activate	VERB
bptjm-64	52	31	cells	cell	NOUN
bptjm-64	52	32	by	by	ADP
bptjm-64	52	33	enhancing	enhance	VERB
bptjm-64	52	34	local	local	ADJ
bptjm-64	52	35	evasion	evasion	NOUN
bptjm-64	52	36	mechanisms.14,15	mechanisms.14,15	NOUN
bptjm-64	52	37	these	these	DET
bptjm-64	52	38	immune	immune	ADJ
bptjm-64	52	39	checkpoint	checkpoint	NOUN
bptjm-64	52	40	inhibitors	inhibitor	NOUN
bptjm-64	52	41	(	(	PUNCT
bptjm-64	52	42	icis	icis	NOUN
bptjm-64	52	43	)	)	PUNCT
bptjm-64	52	44	interfere	interfere	VERB
bptjm-64	52	45	with	with	ADP
bptjm-64	52	46	t	t	NOUN
bptjm-64	52	47	cell	cell	NOUN
bptjm-64	52	48	functionality	functionality	NOUN
bptjm-64	52	49	,	,	PUNCT
bptjm-64	52	50	leading	lead	VERB
bptjm-64	52	51	to	to	ADP
bptjm-64	52	52	berkeley	berkeley	PROPN
bptjm-64	52	53	pharma	pharma	PROPN
bptjm-64	52	54	tech	tech	NOUN
bptjm-64	52	55	journal	journal	NOUN
bptjm-64	52	56	of	of	ADP
bptjm-64	52	57	medicine	medicine	NOUN
bptjm-64	53	1	|	|	ADV
bptjm-64	53	2	119	119	NUM
bptjm-64	53	3	an	an	DET
bptjm-64	53	4	increase	increase	NOUN
bptjm-64	53	5	in	in	ADP
bptjm-64	53	6	exhausted	exhausted	ADJ
bptjm-64	53	7	t	t	NOUN
bptjm-64	53	8	cell	cell	NOUN
bptjm-64	53	9	populations	population	NOUN
bptjm-64	53	10	,	,	PUNCT
bptjm-64	53	11	both	both	PRON
bptjm-64	53	12	of	of	ADP
bptjm-64	53	13	which	which	PRON
bptjm-64	53	14	contribute	contribute	VERB
bptjm-64	53	15	to	to	ADP
bptjm-64	53	16	adaptive	adaptive	ADJ
bptjm-64	53	17	resistance	resistance	NOUN
bptjm-64	53	18	against	against	ADP
bptjm-64	53	19	immune	immune	ADJ
bptjm-64	53	20	checkpoint	checkpoint	NOUN
bptjm-64	53	21	blockade	blockade	NOUN
bptjm-64	53	22	therapy.16	therapy.16	PROPN
bptjm-64	53	23	researchers	researcher	NOUN
bptjm-64	53	24	conducted	conduct	VERB
bptjm-64	53	25	clinical	clinical	ADJ
bptjm-64	53	26	trials	trial	NOUN
bptjm-64	53	27	investigating	investigate	VERB
bptjm-64	53	28	the	the	DET
bptjm-64	53	29	interaction	interaction	NOUN
bptjm-64	53	30	between	between	ADP
bptjm-64	53	31	pd-1	pd-1	ADJ
bptjm-64	53	32	and	and	CCONJ
bptjm-64	53	33	pd	pd	PROPN
bptjm-64	53	34	-	-	PROPN
bptjm-64	53	35	l1	l1	PROPN
bptjm-64	53	36	on	on	ADP
bptjm-64	53	37	cytotoxic	cytotoxic	ADJ
bptjm-64	53	38	t	t	NOUN
bptjm-64	53	39	cells	cell	NOUN
bptjm-64	53	40	in	in	ADP
bptjm-64	53	41	mice	mouse	NOUN
bptjm-64	53	42	.	.	PUNCT
bptjm-64	54	1	they	they	PRON
bptjm-64	54	2	observed	observe	VERB
bptjm-64	54	3	accelerated	accelerate	VERB
bptjm-64	54	4	tumor	tumor	NOUN
bptjm-64	54	5	growth	growth	NOUN
bptjm-64	54	6	,	,	PUNCT
bptjm-64	54	7	which	which	PRON
bptjm-64	54	8	was	be	AUX
bptjm-64	54	9	mitigated	mitigate	VERB
bptjm-64	54	10	when	when	SCONJ
bptjm-64	54	11	treated	treat	VERB
bptjm-64	54	12	with	with	ADP
bptjm-64	54	13	an	an	DET
bptjm-64	54	14	anti	anti	ADJ
bptjm-64	54	15	-	-	ADJ
bptjm-64	54	16	pd	pd	ADJ
bptjm-64	54	17	-	-	ADJ
bptjm-64	54	18	l1	l1	NOUN
bptjm-64	54	19	antibody	antibody	NOUN
bptjm-64	54	20	or	or	CCONJ
bptjm-64	54	21	through	through	ADP
bptjm-64	54	22	pd-1	pd-1	ADJ
bptjm-64	54	23	knockout	knockout	NOUN
bptjm-64	54	24	,	,	PUNCT
bptjm-64	54	25	resulting	result	VERB
bptjm-64	54	26	in	in	ADP
bptjm-64	54	27	reduced	reduce	VERB
bptjm-64	54	28	tumor	tumor	NOUN
bptjm-64	54	29	growth	growth	NOUN
bptjm-64	54	30	.	.	PUNCT
bptjm-64	55	1	similar	similar	ADJ
bptjm-64	55	2	�	�	PROPN
bptjm-64	55	3	ndings	nding	NOUN
bptjm-64	55	4	were	be	AUX
bptjm-64	55	5	noted	note	VERB
bptjm-64	55	6	in	in	ADP
bptjm-64	55	7	human	human	ADJ
bptjm-64	55	8	trials.17	trials.17	NOUN
bptjm-64	55	9	for	for	ADP
bptjm-64	55	10	instance	instance	NOUN
bptjm-64	55	11	,	,	PUNCT
bptjm-64	55	12	qian	qian	PROPN
bptjm-64	55	13	et	et	PROPN
bptjm-64	55	14	al	al	PROPN
bptjm-64	55	15	.	.	PROPN
bptjm-64	55	16	demonstrated	demonstrate	VERB
bptjm-64	55	17	in	in	ADP
bptjm-64	55	18	a	a	DET
bptjm-64	55	19	study	study	NOUN
bptjm-64	55	20	focusing	focus	VERB
bptjm-64	55	21	on	on	ADP
bptjm-64	55	22	glioma	glioma	ADJ
bptjm-64	55	23	cancer	cancer	NOUN
bptjm-64	55	24	that	that	PRON
bptjm-64	55	25	tumor	tumor	NOUN
bptjm-64	55	26	-	-	PUNCT
bptjm-64	55	27	in	in	ADP
bptjm-64	55	28	�	�	PROPN
bptjm-64	55	29	ltrating	ltrating	NOUN
bptjm-64	55	30	t	t	NOUN
bptjm-64	55	31	cells	cell	NOUN
bptjm-64	55	32	become	become	VERB
bptjm-64	55	33	activated	activate	VERB
bptjm-64	55	34	and	and	CCONJ
bptjm-64	55	35	can	can	AUX
bptjm-64	55	36	increase	increase	VERB
bptjm-64	55	37	pd-1	pd-1	ADP
bptjm-64	55	38	expression	expression	NOUN
bptjm-64	55	39	,	,	PUNCT
bptjm-64	55	40	leading	lead	VERB
bptjm-64	55	41	to	to	ADP
bptjm-64	55	42	t	t	NOUN
bptjm-64	55	43	cell	cell	NOUN
bptjm-64	55	44	dysfunction	dysfunction	NOUN
bptjm-64	55	45	mediated	mediate	VERB
bptjm-64	55	46	by	by	ADP
bptjm-64	55	47	immune	immune	ADJ
bptjm-64	55	48	checkpoint	checkpoint	NOUN
bptjm-64	55	49	inhibitors	inhibitor	NOUN
bptjm-64	55	50	(	(	PUNCT
bptjm-64	55	51	icis	icis	NOUN
bptjm-64	55	52	)	)	PUNCT
bptjm-64	55	53	.	.	PUNCT
bptjm-64	56	1	consequently	consequently	ADV
bptjm-64	56	2	,	,	PUNCT
bptjm-64	56	3	the	the	DET
bptjm-64	56	4	researchers	researcher	NOUN
bptjm-64	56	5	suggested	suggest	VERB
bptjm-64	56	6	that	that	SCONJ
bptjm-64	56	7	anti	anti	ADJ
bptjm-64	56	8	-	-	ADJ
bptjm-64	56	9	pd	pd	ADJ
bptjm-64	56	10	therapy	therapy	NOUN
bptjm-64	56	11	could	could	AUX
bptjm-64	56	12	impede	impede	VERB
bptjm-64	56	13	glioma	glioma	NOUN
bptjm-64	56	14	cancer	cancer	NOUN
bptjm-64	56	15	progression.17	progression.17	NOUN
bptjm-64	56	16	another	another	DET
bptjm-64	56	17	instance	instance	NOUN
bptjm-64	56	18	illustrating	illustrate	VERB
bptjm-64	56	19	the	the	DET
bptjm-64	56	20	e	e	NOUN
bptjm-64	56	21	�	�	PROPN
bptjm-64	56	22	ectiveness	ectiveness	NOUN
bptjm-64	56	23	of	of	ADP
bptjm-64	56	24	immune	immune	ADJ
bptjm-64	56	25	checkpoint	checkpoint	NOUN
bptjm-64	56	26	inhibition	inhibition	NOUN
bptjm-64	56	27	therapy	therapy	NOUN
bptjm-64	56	28	in	in	ADP
bptjm-64	56	29	microsatellite	microsatellite	ADJ
bptjm-64	56	30	instability	instability	NOUN
bptjm-64	56	31	/	/	SYM
bptjm-64	56	32	de	de	X
bptjm-64	56	33	�	�	PROPN
bptjm-64	56	34	cient	cient	NOUN
bptjm-64	56	35	mismatch	mismatch	NOUN
bptjm-64	56	36	repair	repair	NOUN
bptjm-64	56	37	(	(	PUNCT
bptjm-64	56	38	msi	msi	PROPN
bptjm-64	56	39	/	/	SYM
bptjm-64	56	40	dmmr	dmmr	NOUN
bptjm-64	56	41	)	)	PUNCT
bptjm-64	56	42	tumors	tumor	NOUN
bptjm-64	56	43	comes	come	VERB
bptjm-64	56	44	from	from	ADP
bptjm-64	56	45	the	the	DET
bptjm-64	56	46	ongoing	ongoing	ADJ
bptjm-64	56	47	trial	trial	NOUN
bptjm-64	56	48	conducted	conduct	VERB
bptjm-64	56	49	by	by	ADP
bptjm-64	56	50	imhotep	imhotep	NOUN
bptjm-64	56	51	,	,	PUNCT
bptjm-64	56	52	which	which	PRON
bptjm-64	56	53	showcases	showcase	VERB
bptjm-64	56	54	a	a	DET
bptjm-64	56	55	group	group	NOUN
bptjm-64	56	56	of	of	ADP
bptjm-64	56	57	120	120	NUM
bptjm-64	56	58	patients	patient	NOUN
bptjm-64	56	59	bene	bene	PROPN
bptjm-64	56	60	�	�	PROPN
bptjm-64	56	61	ting	ting	NOUN
bptjm-64	56	62	from	from	ADP
bptjm-64	56	63	anti	anti	ADJ
bptjm-64	56	64	-	-	ADJ
bptjm-64	56	65	pd	pd	ADJ
bptjm-64	56	66	therapy.18	therapy.18	PROPN
bptjm-64	56	67	while	while	SCONJ
bptjm-64	56	68	anti	anti	ADJ
bptjm-64	56	69	-	-	ADJ
bptjm-64	56	70	pd	pd	ADJ
bptjm-64	56	71	therapy	therapy	NOUN
bptjm-64	56	72	has	have	AUX
bptjm-64	56	73	shown	show	VERB
bptjm-64	56	74	success	success	NOUN
bptjm-64	56	75	in	in	ADP
bptjm-64	56	76	certain	certain	ADJ
bptjm-64	56	77	patients	patient	NOUN
bptjm-64	56	78	,	,	PUNCT
bptjm-64	56	79	others	other	NOUN
bptjm-64	56	80	have	have	AUX
bptjm-64	56	81	exhibited	exhibit	VERB
bptjm-64	56	82	poor	poor	ADJ
bptjm-64	56	83	responses	response	NOUN
bptjm-64	56	84	due	due	ADP
bptjm-64	56	85	to	to	ADP
bptjm-64	56	86	both	both	CCONJ
bptjm-64	56	87	primary	primary	ADJ
bptjm-64	56	88	and	and	CCONJ
bptjm-64	56	89	acquired	acquire	VERB
bptjm-64	56	90	resistance	resistance	NOUN
bptjm-64	56	91	mechanisms	mechanism	NOUN
bptjm-64	56	92	working	work	VERB
bptjm-64	56	93	against	against	ADP
bptjm-64	56	94	the	the	DET
bptjm-64	56	95	treatment	treatment	NOUN
bptjm-64	56	96	.	.	PUNCT
bptjm-64	57	1	e	e	X
bptjm-64	57	2	�	�	NOUN
bptjm-64	57	3	ective	ective	ADJ
bptjm-64	57	4	anti	anti	ADJ
bptjm-64	57	5	-	-	ADJ
bptjm-64	57	6	pd	pd	ADJ
bptjm-64	57	7	therapy	therapy	NOUN
bptjm-64	57	8	hinges	hinge	VERB
bptjm-64	57	9	on	on	ADP
bptjm-64	57	10	the	the	DET
bptjm-64	57	11	precise	precise	ADJ
bptjm-64	57	12	blockade	blockade	NOUN
bptjm-64	57	13	of	of	ADP
bptjm-64	57	14	the	the	DET
bptjm-64	57	15	pd-1	pd-1	ADJ
bptjm-64	57	16	and	and	CCONJ
bptjm-64	57	17	pd	pd	PROPN
bptjm-64	57	18	-	-	PROPN
bptjm-64	57	19	l1	l1	PROPN
bptjm-64	57	20	pathways	pathway	NOUN
bptjm-64	57	21	.	.	PUNCT
bptjm-64	58	1	however	however	ADV
bptjm-64	58	2	,	,	PUNCT
bptjm-64	58	3	if	if	SCONJ
bptjm-64	58	4	either	either	DET
bptjm-64	58	5	protein	protein	NOUN
bptjm-64	58	6	lacks	lack	VERB
bptjm-64	58	7	expression	expression	NOUN
bptjm-64	58	8	,	,	PUNCT
bptjm-64	58	9	the	the	DET
bptjm-64	58	10	treatment	treatment	NOUN
bptjm-64	58	11	proves	prove	VERB
bptjm-64	58	12	ine	ine	PROPN
bptjm-64	58	13	�	�	PROPN
bptjm-64	58	14	ective	ective	NOUN
bptjm-64	58	15	against	against	ADP
bptjm-64	58	16	the	the	DET
bptjm-64	58	17	tumor	tumor	NOUN
bptjm-64	58	18	cells	cell	NOUN
bptjm-64	58	19	—	—	PUNCT
bptjm-64	58	20	a	a	DET
bptjm-64	58	21	direct	direct	ADJ
bptjm-64	58	22	primary	primary	ADJ
bptjm-64	58	23	resistance	resistance	NOUN
bptjm-64	58	24	mechanism	mechanism	NOUN
bptjm-64	58	25	observed	observe	VERB
bptjm-64	58	26	in	in	ADP
bptjm-64	58	27	some	some	DET
bptjm-64	58	28	cases.15	cases.15	NOUN
bptjm-64	58	29	furthermore	furthermore	ADV
bptjm-64	58	30	,	,	PUNCT
bptjm-64	58	31	certain	certain	ADJ
bptjm-64	58	32	cancers	cancer	NOUN
bptjm-64	58	33	lack	lack	VERB
bptjm-64	58	34	tumor	tumor	NOUN
bptjm-64	58	35	-	-	PUNCT
bptjm-64	58	36	in	in	ADP
bptjm-64	58	37	�	�	PROPN
bptjm-64	58	38	ltrating	ltrating	NOUN
bptjm-64	58	39	t	t	NOUN
bptjm-64	58	40	cells	cell	NOUN
bptjm-64	58	41	or	or	CCONJ
bptjm-64	58	42	pd	pd	PROPN
bptjm-64	58	43	-	-	PUNCT
bptjm-64	58	44	l1	l1	PROPN
bptjm-64	58	45	,	,	PUNCT
bptjm-64	58	46	rendering	render	VERB
bptjm-64	58	47	them	they	PRON
bptjm-64	58	48	unresponsive	unresponsive	ADJ
bptjm-64	58	49	to	to	ADP
bptjm-64	58	50	anti	anti	ADJ
bptjm-64	58	51	-	-	ADJ
bptjm-64	58	52	pd	pd	ADJ
bptjm-64	58	53	therapy.15	therapy.15	NOUN
bptjm-64	58	54	to	to	PART
bptjm-64	58	55	combat	combat	VERB
bptjm-64	58	56	this	this	DET
bptjm-64	58	57	adaptive	adaptive	ADJ
bptjm-64	58	58	resistance	resistance	NOUN
bptjm-64	58	59	,	,	PUNCT
bptjm-64	58	60	combination	combination	NOUN
bptjm-64	58	61	therapy	therapy	NOUN
bptjm-64	58	62	involving	involve	VERB
bptjm-64	58	63	both	both	PRON
bptjm-64	58	64	immunoand	immunoand	NOUN
bptjm-64	58	65	chemo	chemo	NOUN
bptjm-64	58	66	-	-	PUNCT
bptjm-64	58	67	therapies	therapy	NOUN
bptjm-64	58	68	has	have	AUX
bptjm-64	58	69	been	be	AUX
bptjm-64	58	70	proposed	propose	VERB
bptjm-64	58	71	as	as	ADP
bptjm-64	58	72	a	a	DET
bptjm-64	58	73	more	more	ADJ
bptjm-64	58	74	e	e	NOUN
bptjm-64	58	75	�	�	NOUN
bptjm-64	58	76	ective	ective	ADJ
bptjm-64	58	77	approach	approach	NOUN
bptjm-64	58	78	to	to	ADP
bptjm-64	58	79	treating	treat	VERB
bptjm-64	58	80	cancer	cancer	NOUN
bptjm-64	58	81	compared	compare	VERB
bptjm-64	58	82	to	to	ADP
bptjm-64	58	83	immunotherapy	immunotherapy	NOUN
bptjm-64	58	84	alone	alone	ADV
bptjm-64	58	85	.	.	PUNCT
bptjm-64	59	1	3.2	3.2	NUM
bptjm-64	59	2	ctla-4	ctla-4	NUM
bptjm-64	59	3	ctla-4	ctla-4	NOUN
bptjm-64	59	4	,	,	PUNCT
bptjm-64	59	5	a	a	DET
bptjm-64	59	6	protein	protein	NOUN
bptjm-64	59	7	associated	associate	VERB
bptjm-64	59	8	with	with	ADP
bptjm-64	59	9	cytotoxic	cytotoxic	ADJ
bptjm-64	59	10	t	t	NOUN
bptjm-64	59	11	lymphocytes	lymphocyte	NOUN
bptjm-64	59	12	,	,	PUNCT
bptjm-64	59	13	plays	play	VERB
bptjm-64	59	14	a	a	DET
bptjm-64	59	15	role	role	NOUN
bptjm-64	59	16	in	in	ADP
bptjm-64	59	17	dampening	dampen	VERB
bptjm-64	59	18	the	the	DET
bptjm-64	59	19	anti	anti	ADJ
bptjm-64	59	20	-	-	ADJ
bptjm-64	59	21	tumor	tumor	ADJ
bptjm-64	59	22	immune	immune	ADJ
bptjm-64	59	23	response	response	NOUN
bptjm-64	59	24	by	by	ADP
bptjm-64	59	25	regulating	regulate	VERB
bptjm-64	59	26	the	the	DET
bptjm-64	59	27	activation	activation	NOUN
bptjm-64	59	28	of	of	ADP
bptjm-64	59	29	ctls	ctls	NOUN
bptjm-64	59	30	,	,	PUNCT
bptjm-64	59	31	thus	thus	ADV
bptjm-64	59	32	hindering	hinder	VERB
bptjm-64	59	33	an	an	DET
bptjm-64	59	34	e	e	NOUN
bptjm-64	59	35	�	�	PROPN
bptjm-64	59	36	cient	cient	NOUN
bptjm-64	59	37	immune	immune	ADJ
bptjm-64	59	38	reaction.14	reaction.14	NOUN
bptjm-64	59	39	unlike	unlike	ADP
bptjm-64	59	40	pd-1	pd-1	ADP
bptjm-64	59	41	,	,	PUNCT
bptjm-64	59	42	which	which	PRON
bptjm-64	59	43	manages	manage	VERB
bptjm-64	59	44	programmed	program	VERB
bptjm-64	59	45	cell	cell	NOUN
bptjm-64	59	46	death	death	NOUN
bptjm-64	59	47	,	,	PUNCT
bptjm-64	59	48	ctla-4	ctla-4	PRON
bptjm-64	59	49	dictates	dictate	VERB
bptjm-64	59	50	whether	whether	SCONJ
bptjm-64	59	51	a	a	DET
bptjm-64	59	52	t	t	NOUN
bptjm-64	59	53	cell	cell	NOUN
bptjm-64	59	54	berkeley	berkeley	PROPN
bptjm-64	59	55	pharma	pharma	PROPN
bptjm-64	59	56	tech	tech	NOUN
bptjm-64	59	57	journal	journal	NOUN
bptjm-64	59	58	of	of	ADP
bptjm-64	59	59	medicine	medicine	NOUN
bptjm-64	59	60	|	|	ADV
bptjm-64	59	61	120	120	NUM
bptjm-64	59	62	undergoes	undergoe	NOUN
bptjm-64	59	63	activation	activation	NOUN
bptjm-64	59	64	or	or	CCONJ
bptjm-64	59	65	remains	remain	VERB
bptjm-64	59	66	in	in	ADP
bptjm-64	59	67	a	a	DET
bptjm-64	59	68	state	state	NOUN
bptjm-64	59	69	of	of	ADP
bptjm-64	59	70	rest	rest	NOUN
bptjm-64	59	71	termed	term	VERB
bptjm-64	59	72	exhaustion	exhaustion	NOUN
bptjm-64	59	73	.	.	PUNCT
bptjm-64	60	1	it	it	PRON
bptjm-64	60	2	is	be	AUX
bptjm-64	60	3	present	present	ADJ
bptjm-64	60	4	on	on	ADP
bptjm-64	60	5	the	the	DET
bptjm-64	60	6	surface	surface	NOUN
bptjm-64	60	7	of	of	ADP
bptjm-64	60	8	stimulated	stimulated	ADJ
bptjm-64	60	9	functional	functional	ADJ
bptjm-64	60	10	t	t	NOUN
bptjm-64	60	11	cells	cell	NOUN
bptjm-64	60	12	,	,	PUNCT
bptjm-64	60	13	and	and	CCONJ
bptjm-64	60	14	activation	activation	NOUN
bptjm-64	60	15	occurs	occur	VERB
bptjm-64	60	16	upon	upon	SCONJ
bptjm-64	60	17	stimulation	stimulation	NOUN
bptjm-64	60	18	from	from	ADP
bptjm-64	60	19	a	a	DET
bptjm-64	60	20	t	t	NOUN
bptjm-64	60	21	cell	cell	NOUN
bptjm-64	60	22	receptor.14	receptor.14	NOUN
bptjm-64	60	23	ctla-4	ctla-4	PRON
bptjm-64	60	24	competes	compete	VERB
bptjm-64	60	25	with	with	ADP
bptjm-64	60	26	cd28	cd28	PROPN
bptjm-64	60	27	for	for	ADP
bptjm-64	60	28	binding	bind	VERB
bptjm-64	60	29	to	to	ADP
bptjm-64	60	30	the	the	DET
bptjm-64	60	31	t	t	PROPN
bptjm-64	60	32	cell	cell	NOUN
bptjm-64	60	33	ligand	ligand	NOUN
bptjm-64	60	34	,	,	PUNCT
bptjm-64	60	35	blocking	block	VERB
bptjm-64	60	36	the	the	DET
bptjm-64	60	37	crucial	crucial	ADJ
bptjm-64	60	38	costimulation	costimulation	NOUN
bptjm-64	60	39	signals	signal	NOUN
bptjm-64	60	40	required	require	VERB
bptjm-64	60	41	for	for	ADP
bptjm-64	60	42	activation.14	activation.14	NOUN
bptjm-64	60	43	due	due	ADP
bptjm-64	60	44	to	to	ADP
bptjm-64	60	45	its	its	PRON
bptjm-64	60	46	higher	high	ADJ
bptjm-64	60	47	a	a	DET
bptjm-64	60	48	�	�	NOUN
bptjm-64	60	49	nity	nity	NOUN
bptjm-64	60	50	for	for	ADP
bptjm-64	60	51	the	the	DET
bptjm-64	60	52	ligand	ligand	NOUN
bptjm-64	60	53	,	,	PUNCT
bptjm-64	60	54	ctla-4	ctla-4	PRON
bptjm-64	60	55	binds	bind	VERB
bptjm-64	60	56	more	more	ADJ
bptjm-64	60	57	e	e	NOUN
bptjm-64	60	58	�	�	NOUN
bptjm-64	60	59	ectively	ectively	ADJ
bptjm-64	60	60	,	,	PUNCT
bptjm-64	60	61	leading	lead	VERB
bptjm-64	60	62	to	to	ADP
bptjm-64	60	63	t	t	NOUN
bptjm-64	60	64	cell	cell	NOUN
bptjm-64	60	65	exhaustion	exhaustion	NOUN
bptjm-64	60	66	and	and	CCONJ
bptjm-64	60	67	inhibiting	inhibit	VERB
bptjm-64	60	68	activation	activation	NOUN
bptjm-64	60	69	.	.	PUNCT
bptjm-64	61	1	using	use	VERB
bptjm-64	61	2	an	an	DET
bptjm-64	61	3	antibody	antibody	NOUN
bptjm-64	61	4	that	that	PRON
bptjm-64	61	5	selectively	selectively	ADV
bptjm-64	61	6	targets	target	VERB
bptjm-64	61	7	and	and	CCONJ
bptjm-64	61	8	binds	bind	VERB
bptjm-64	61	9	to	to	ADP
bptjm-64	61	10	ctla-4	ctla-4	NOUN
bptjm-64	61	11	can	can	AUX
bptjm-64	61	12	restore	restore	VERB
bptjm-64	61	13	t	t	NOUN
bptjm-64	61	14	cell	cell	NOUN
bptjm-64	61	15	activation	activation	NOUN
bptjm-64	61	16	by	by	ADP
bptjm-64	61	17	eliminating	eliminate	VERB
bptjm-64	61	18	the	the	DET
bptjm-64	61	19	competition	competition	NOUN
bptjm-64	61	20	for	for	ADP
bptjm-64	61	21	t	t	PROPN
bptjm-64	61	22	cell	cell	NOUN
bptjm-64	61	23	ligand	ligand	NOUN
bptjm-64	61	24	binding	bind	VERB
bptjm-64	61	25	with	with	ADP
bptjm-64	61	26	costimulation	costimulation	NOUN
bptjm-64	61	27	signals.14	signals.14	NOUN
bptjm-64	61	28	additionally	additionally	ADV
bptjm-64	61	29	,	,	PUNCT
bptjm-64	61	30	ctla-4	ctla-4	NOUN
bptjm-64	61	31	is	be	AUX
bptjm-64	61	32	prominently	prominently	ADV
bptjm-64	61	33	expressed	express	VERB
bptjm-64	61	34	on	on	ADP
bptjm-64	61	35	the	the	DET
bptjm-64	61	36	surface	surface	NOUN
bptjm-64	61	37	of	of	ADP
bptjm-64	61	38	tregs	treg	NOUN
bptjm-64	61	39	,	,	PUNCT
bptjm-64	61	40	which	which	PRON
bptjm-64	61	41	play	play	VERB
bptjm-64	61	42	a	a	DET
bptjm-64	61	43	role	role	NOUN
bptjm-64	61	44	in	in	ADP
bptjm-64	61	45	immune	immune	ADJ
bptjm-64	61	46	response	response	NOUN
bptjm-64	61	47	suppression.14	suppression.14	PROPN
bptjm-64	61	48	research	research	NOUN
bptjm-64	61	49	indicates	indicate	VERB
bptjm-64	61	50	that	that	SCONJ
bptjm-64	61	51	ctla-4	ctla-4	NOUN
bptjm-64	61	52	plays	play	VERB
bptjm-64	61	53	a	a	DET
bptjm-64	61	54	pivotal	pivotal	ADJ
bptjm-64	61	55	role	role	NOUN
bptjm-64	61	56	in	in	ADP
bptjm-64	61	57	regulating	regulate	VERB
bptjm-64	61	58	the	the	DET
bptjm-64	61	59	function	function	NOUN
bptjm-64	61	60	and	and	CCONJ
bptjm-64	61	61	production	production	NOUN
bptjm-64	61	62	of	of	ADP
bptjm-64	61	63	tregs,14	tregs,14	ADP
bptjm-64	61	64	which	which	PRON
bptjm-64	61	65	in	in	ADP
bptjm-64	61	66	turn	turn	NOUN
bptjm-64	61	67	directly	directly	ADV
bptjm-64	61	68	suppress	suppress	VERB
bptjm-64	61	69	the	the	DET
bptjm-64	61	70	activation	activation	NOUN
bptjm-64	61	71	of	of	ADP
bptjm-64	61	72	target	target	NOUN
bptjm-64	61	73	immune	immune	ADJ
bptjm-64	61	74	cells	cell	NOUN
bptjm-64	61	75	by	by	ADP
bptjm-64	61	76	increasing	increase	VERB
bptjm-64	61	77	ctla-4	ctla-4	NUM
bptjm-64	61	78	expression.19	expression.19	NOUN
bptjm-64	61	79	utilizing	utilize	VERB
bptjm-64	61	80	ctla-4	ctla-4	NOUN
bptjm-64	61	81	blockade	blockade	NOUN
bptjm-64	61	82	therapy	therapy	NOUN
bptjm-64	61	83	has	have	AUX
bptjm-64	61	84	emerged	emerge	VERB
bptjm-64	61	85	as	as	ADP
bptjm-64	61	86	an	an	DET
bptjm-64	61	87	e	e	NOUN
bptjm-64	61	88	�	�	NOUN
bptjm-64	61	89	ective	ective	ADJ
bptjm-64	61	90	strategy	strategy	NOUN
bptjm-64	61	91	for	for	ADP
bptjm-64	61	92	enhancing	enhance	VERB
bptjm-64	61	93	anti	anti	ADJ
bptjm-64	61	94	-	-	ADJ
bptjm-64	61	95	tumor	tumor	ADJ
bptjm-64	61	96	immune	immune	ADJ
bptjm-64	61	97	responses.14	responses.14	PROPN
bptjm-64	61	98	the	the	DET
bptjm-64	61	99	fda	fda	PROPN
bptjm-64	61	100	-	-	PUNCT
bptjm-64	61	101	approved	approve	VERB
bptjm-64	61	102	monoclonal	monoclonal	NOUN
bptjm-64	61	103	anti	anti	ADJ
bptjm-64	61	104	-	-	ADJ
bptjm-64	61	105	ctla-4	ctla-4	ADJ
bptjm-64	61	106	antibody	antibody	NOUN
bptjm-64	61	107	,	,	PUNCT
bptjm-64	61	108	ipilimumab	ipilimumab	ADV
bptjm-64	61	109	,	,	PUNCT
bptjm-64	61	110	has	have	AUX
bptjm-64	61	111	signi	signi	ADJ
bptjm-64	61	112	�	�	PROPN
bptjm-64	61	113	cantly	cantly	ADV
bptjm-64	61	114	enhanced	enhance	VERB
bptjm-64	61	115	overall	overall	ADJ
bptjm-64	61	116	survival	survival	NOUN
bptjm-64	61	117	rates	rate	NOUN
bptjm-64	61	118	among	among	ADP
bptjm-64	61	119	patients	patient	NOUN
bptjm-64	61	120	with	with	ADP
bptjm-64	61	121	malignant	malignant	ADJ
bptjm-64	61	122	melanoma.4	melanoma.4	NOUN
bptjm-64	62	1	it	it	PRON
bptjm-64	62	2	's	be	AUX
bptjm-64	62	3	worth	worth	ADJ
bptjm-64	62	4	noting	note	VERB
bptjm-64	62	5	that	that	SCONJ
bptjm-64	62	6	while	while	SCONJ
bptjm-64	62	7	anti	anti	ADJ
bptjm-64	62	8	-	-	ADJ
bptjm-64	62	9	ctla-4	ctla-4	NOUN
bptjm-64	62	10	antibodies	antibody	NOUN
bptjm-64	62	11	show	show	VERB
bptjm-64	62	12	e	e	NOUN
bptjm-64	62	13	�	�	NOUN
bptjm-64	62	14	cacy	cacy	NOUN
bptjm-64	62	15	in	in	ADP
bptjm-64	62	16	late	late	ADJ
bptjm-64	62	17	-	-	PUNCT
bptjm-64	62	18	stage	stage	NOUN
bptjm-64	62	19	melanoma	melanoma	NOUN
bptjm-64	62	20	,	,	PUNCT
bptjm-64	62	21	their	their	PRON
bptjm-64	62	22	e	e	NOUN
bptjm-64	62	23	�	�	PROPN
bptjm-64	62	24	ectiveness	ectiveness	NOUN
bptjm-64	62	25	in	in	ADP
bptjm-64	62	26	other	other	ADJ
bptjm-64	62	27	tumor	tumor	NOUN
bptjm-64	62	28	types	type	NOUN
bptjm-64	62	29	is	be	AUX
bptjm-64	62	30	limited	limited	ADJ
bptjm-64	62	31	.	.	PUNCT
bptjm-64	63	1	consequently	consequently	ADV
bptjm-64	63	2	,	,	PUNCT
bptjm-64	63	3	clinical	clinical	ADJ
bptjm-64	63	4	trials	trial	NOUN
bptjm-64	63	5	are	be	AUX
bptjm-64	63	6	exploring	explore	VERB
bptjm-64	63	7	combination	combination	NOUN
bptjm-64	63	8	therapies	therapy	NOUN
bptjm-64	63	9	to	to	PART
bptjm-64	63	10	address	address	VERB
bptjm-64	63	11	this	this	DET
bptjm-64	63	12	limitation.4	limitation.4	NOUN
bptjm-64	63	13	3.3	3.3	NUM
bptjm-64	63	14	lag-3	lag-3	PUNCT
bptjm-64	63	15	lymphocyte	lymphocyte	ADJ
bptjm-64	63	16	activation	activation	NOUN
bptjm-64	63	17	gene	gene	NOUN
bptjm-64	63	18	3	3	NUM
bptjm-64	63	19	(	(	PUNCT
bptjm-64	63	20	lag-3	lag-3	X
bptjm-64	63	21	)	)	PUNCT
bptjm-64	63	22	serves	serve	VERB
bptjm-64	63	23	as	as	ADP
bptjm-64	63	24	an	an	DET
bptjm-64	63	25	immune	immune	ADJ
bptjm-64	63	26	checkpoint	checkpoint	NOUN
bptjm-64	63	27	receptor	receptor	NOUN
bptjm-64	63	28	,	,	PUNCT
bptjm-64	63	29	capable	capable	ADJ
bptjm-64	63	30	of	of	ADP
bptjm-64	63	31	dampening	dampening	ADJ
bptjm-64	63	32	responses	response	NOUN
bptjm-64	63	33	orchestrated	orchestrate	VERB
bptjm-64	63	34	by	by	ADP
bptjm-64	63	35	t	t	PROPN
bptjm-64	63	36	and	and	CCONJ
bptjm-64	63	37	nk	nk	PROPN
bptjm-64	63	38	cells	cell	NOUN
bptjm-64	63	39	,	,	PUNCT
bptjm-64	63	40	thereby	thereby	ADV
bptjm-64	63	41	fostering	foster	VERB
bptjm-64	63	42	a	a	DET
bptjm-64	63	43	hyporesponsive	hyporesponsive	ADJ
bptjm-64	63	44	condition	condition	NOUN
bptjm-64	63	45	,	,	PUNCT
bptjm-64	63	46	which	which	PRON
bptjm-64	63	47	aids	aid	VERB
bptjm-64	63	48	tumors	tumor	NOUN
bptjm-64	63	49	in	in	ADP
bptjm-64	63	50	escaping	escape	VERB
bptjm-64	63	51	immune	immune	ADJ
bptjm-64	63	52	surveillance	surveillance	NOUN
bptjm-64	63	53	.	.	PUNCT
bptjm-64	64	1	typically	typically	ADV
bptjm-64	64	2	found	find	VERB
bptjm-64	64	3	on	on	ADP
bptjm-64	64	4	activated	activate	VERB
bptjm-64	64	5	and	and	CCONJ
bptjm-64	64	6	exhausted	exhausted	ADJ
bptjm-64	64	7	t	t	PROPN
bptjm-64	64	8	and	and	CCONJ
bptjm-64	64	9	nk	nk	PROPN
bptjm-64	64	10	cells	cell	NOUN
bptjm-64	64	11	,	,	PUNCT
bptjm-64	64	12	b	b	NOUN
bptjm-64	64	13	cells	cell	NOUN
bptjm-64	64	14	,	,	PUNCT
bptjm-64	64	15	dendritic	dendritic	ADJ
bptjm-64	64	16	cells	cell	NOUN
bptjm-64	64	17	,	,	PUNCT
bptjm-64	64	18	and	and	CCONJ
bptjm-64	64	19	tregs	treg	NOUN
bptjm-64	64	20	,	,	PUNCT
bptjm-64	64	21	lag-3	lag-3	X
bptjm-64	64	22	signaling	signal	VERB
bptjm-64	64	23	inhibits	inhibit	VERB
bptjm-64	64	24	t	t	NOUN
bptjm-64	64	25	cell	cell	NOUN
bptjm-64	64	26	proliferation	proliferation	NOUN
bptjm-64	64	27	,	,	PUNCT
bptjm-64	64	28	cytokine	cytokine	ADJ
bptjm-64	64	29	generation	generation	NOUN
bptjm-64	64	30	,	,	PUNCT
bptjm-64	64	31	and	and	CCONJ
bptjm-64	64	32	cytolytic	cytolytic	ADJ
bptjm-64	64	33	activity.20	activity.20	NOUN
bptjm-64	64	34	additionally	additionally	ADV
bptjm-64	64	35	,	,	PUNCT
bptjm-64	64	36	its	its	PRON
bptjm-64	64	37	presence	presence	NOUN
bptjm-64	64	38	on	on	ADP
bptjm-64	64	39	tregs	treg	NOUN
bptjm-64	64	40	contributes	contribute	VERB
bptjm-64	64	41	to	to	ADP
bptjm-64	64	42	immunosuppression.20	immunosuppression.20	PROPN
bptjm-64	64	43	an	an	DET
bptjm-64	64	44	illustrative	illustrative	ADJ
bptjm-64	64	45	instance	instance	NOUN
bptjm-64	64	46	of	of	ADP
bptjm-64	64	47	this	this	DET
bptjm-64	64	48	phenomenon	phenomenon	NOUN
bptjm-64	64	49	is	be	AUX
bptjm-64	64	50	evident	evident	ADJ
bptjm-64	64	51	in	in	ADP
bptjm-64	64	52	individuals	individual	NOUN
bptjm-64	64	53	a	a	DET
bptjm-64	64	54	�	�	NOUN
bptjm-64	64	55	icted	icte	VERB
bptjm-64	64	56	with	with	ADP
bptjm-64	64	57	chronic	chronic	ADJ
bptjm-64	64	58	lymphocytic	lymphocytic	ADJ
bptjm-64	64	59	leukemia	leukemia	NOUN
bptjm-64	64	60	(	(	PUNCT
bptjm-64	64	61	cll	cll	PROPN
bptjm-64	64	62	)	)	PUNCT
bptjm-64	64	63	,	,	PUNCT
bptjm-64	64	64	where	where	SCONJ
bptjm-64	64	65	there	there	PRON
bptjm-64	64	66	is	be	VERB
bptjm-64	64	67	signi	signi	ADJ
bptjm-64	64	68	�	�	NOUN
bptjm-64	64	69	cant	cant	NOUN
bptjm-64	64	70	dysregulation	dysregulation	NOUN
bptjm-64	64	71	of	of	ADP
bptjm-64	64	72	lag-3	lag-3	ADJ
bptjm-64	64	73	.	.	PUNCT
bptjm-64	65	1	both	both	PRON
bptjm-64	65	2	nk	nk	PROPN
bptjm-64	65	3	cells	cell	NOUN
bptjm-64	65	4	and	and	CCONJ
bptjm-64	65	5	t	t	NOUN
bptjm-64	65	6	cells	cell	NOUN
bptjm-64	65	7	exhibit	exhibit	VERB
bptjm-64	65	8	berkeley	berkeley	PROPN
bptjm-64	65	9	pharma	pharma	PROPN
bptjm-64	65	10	tech	tech	NOUN
bptjm-64	65	11	journal	journal	NOUN
bptjm-64	65	12	of	of	ADP
bptjm-64	65	13	medicine	medicine	NOUN
bptjm-64	65	14	|	|	ADV
bptjm-64	65	15	121	121	NUM
bptjm-64	65	16	heightened	heightened	ADJ
bptjm-64	65	17	lag-3	lag-3	NOUN
bptjm-64	65	18	expression	expression	NOUN
bptjm-64	65	19	,	,	PUNCT
bptjm-64	65	20	and	and	CCONJ
bptjm-64	65	21	elevated	elevated	ADJ
bptjm-64	65	22	levels	level	NOUN
bptjm-64	65	23	of	of	ADP
bptjm-64	65	24	lag-3	lag-3	X
bptjm-64	65	25	or	or	CCONJ
bptjm-64	65	26	soluble	soluble	ADJ
bptjm-64	65	27	lag-3	lag-3	PUNCT
bptjm-64	65	28	(	(	PUNCT
bptjm-64	65	29	slag-3	slag-3	NUM
bptjm-64	65	30	)	)	PUNCT
bptjm-64	65	31	are	be	AUX
bptjm-64	65	32	associated	associate	VERB
bptjm-64	65	33	with	with	ADP
bptjm-64	65	34	adverse	adverse	ADJ
bptjm-64	65	35	cytogenetics	cytogenetic	NOUN
bptjm-64	65	36	and	and	CCONJ
bptjm-64	65	37	unfavorable	unfavorable	ADJ
bptjm-64	65	38	outcomes	outcome	NOUN
bptjm-64	65	39	among	among	ADP
bptjm-64	65	40	cll	cll	PROPN
bptjm-64	65	41	patients	patient	NOUN
bptjm-64	65	42	.	.	PUNCT
bptjm-64	66	1	consequently	consequently	ADV
bptjm-64	66	2	,	,	PUNCT
bptjm-64	66	3	treatment	treatment	NOUN
bptjm-64	66	4	involving	involve	VERB
bptjm-64	66	5	the	the	DET
bptjm-64	66	6	application	application	NOUN
bptjm-64	66	7	of	of	ADP
bptjm-64	66	8	an	an	DET
bptjm-64	66	9	anti	anti	ADJ
bptjm-64	66	10	-	-	ADJ
bptjm-64	66	11	lag-3	lag-3	ADJ
bptjm-64	66	12	blocking	block	VERB
bptjm-64	66	13	antibody	antibody	NOUN
bptjm-64	66	14	called	call	VERB
bptjm-64	66	15	relatlimab	relatlimab	NOUN
bptjm-64	66	16	to	to	ADP
bptjm-64	66	17	peripheral	peripheral	ADJ
bptjm-64	66	18	blood	blood	NOUN
bptjm-64	66	19	mononuclear	mononuclear	ADJ
bptjm-64	66	20	cells	cell	NOUN
bptjm-64	66	21	(	(	PUNCT
bptjm-64	66	22	pbmcs	pbmcs	NOUN
bptjm-64	66	23	)	)	PUNCT
bptjm-64	66	24	has	have	AUX
bptjm-64	66	25	demonstrated	demonstrate	VERB
bptjm-64	66	26	e	e	PROPN
bptjm-64	66	27	�	�	NOUN
bptjm-64	66	28	cacy	cacy	NOUN
bptjm-64	66	29	in	in	ADP
bptjm-64	66	30	reducing	reduce	VERB
bptjm-64	66	31	leukemic	leukemic	ADJ
bptjm-64	66	32	cell	cell	NOUN
bptjm-64	66	33	counts	count	NOUN
bptjm-64	66	34	and	and	CCONJ
bptjm-64	66	35	restoring	restore	VERB
bptjm-64	66	36	nk	nk	PROPN
bptjm-64	66	37	cell	cell	NOUN
bptjm-64	66	38	and	and	CCONJ
bptjm-64	66	39	t	t	NOUN
bptjm-64	66	40	cell	cell	NOUN
bptjm-64	66	41	mediated	mediate	VERB
bptjm-64	66	42	responses.20	responses.20	NOUN
bptjm-64	66	43	as	as	ADP
bptjm-64	66	44	a	a	DET
bptjm-64	66	45	result	result	NOUN
bptjm-64	66	46	,	,	PUNCT
bptjm-64	66	47	interventions	intervention	NOUN
bptjm-64	66	48	aimed	aim	VERB
bptjm-64	66	49	at	at	ADP
bptjm-64	66	50	reinstating	reinstate	VERB
bptjm-64	66	51	t	t	PROPN
bptjm-64	66	52	and	and	CCONJ
bptjm-64	66	53	nk	nk	PROPN
bptjm-64	66	54	cell	cell	NOUN
bptjm-64	66	55	mediated	mediate	VERB
bptjm-64	66	56	responses	response	NOUN
bptjm-64	66	57	through	through	ADP
bptjm-64	66	58	lag-3	lag-3	PUNCT
bptjm-64	66	59	blockade	blockade	NOUN
bptjm-64	66	60	have	have	AUX
bptjm-64	66	61	emerged	emerge	VERB
bptjm-64	66	62	as	as	ADP
bptjm-64	66	63	promising	promise	VERB
bptjm-64	66	64	therapies	therapy	NOUN
bptjm-64	66	65	for	for	ADP
bptjm-64	66	66	hematological	hematological	ADJ
bptjm-64	66	67	malignancies	malignancy	NOUN
bptjm-64	66	68	such	such	ADJ
bptjm-64	66	69	as	as	ADP
bptjm-64	66	70	cll	cll	PROPN
bptjm-64	66	71	,	,	PUNCT
bptjm-64	66	72	follicular	follicular	ADJ
bptjm-64	66	73	lymphoma	lymphoma	NOUN
bptjm-64	66	74	(	(	PUNCT
bptjm-64	66	75	fl	fl	NOUN
bptjm-64	66	76	)	)	PUNCT
bptjm-64	66	77	,	,	PUNCT
bptjm-64	66	78	di	di	NOUN
bptjm-64	66	79	�	�	PROPN
bptjm-64	66	80	use	use	VERB
bptjm-64	66	81	large	large	ADJ
bptjm-64	66	82	b	b	NOUN
bptjm-64	66	83	cell	cell	NOUN
bptjm-64	66	84	lymphoma	lymphoma	NOUN
bptjm-64	66	85	(	(	PUNCT
bptjm-64	66	86	dlbcl	dlbcl	NOUN
bptjm-64	66	87	)	)	PUNCT
bptjm-64	66	88	,	,	PUNCT
bptjm-64	66	89	and	and	CCONJ
bptjm-64	66	90	acute	acute	ADJ
bptjm-64	66	91	myeloid	myeloid	NOUN
bptjm-64	66	92	leukemia	leukemia	NOUN
bptjm-64	66	93	(	(	PUNCT
bptjm-64	66	94	aml).20	aml).20	PROPN
bptjm-64	66	95	3.4	3.4	NUM
bptjm-64	66	96	er	er	INTJ
bptjm-64	66	97	stress	stress	NOUN
bptjm-64	66	98	/	/	SYM
bptjm-64	66	99	ire1a	ire1a	NOUN
bptjm-64	66	100	-	-	PUNCT
bptjm-64	66	101	xbp1	xbp1	PROPN
bptjm-64	67	1	a	a	DET
bptjm-64	67	2	fresh	fresh	ADJ
bptjm-64	67	3	angle	angle	NOUN
bptjm-64	67	4	in	in	ADP
bptjm-64	67	5	cancer	cancer	NOUN
bptjm-64	67	6	therapy	therapy	NOUN
bptjm-64	67	7	involves	involve	VERB
bptjm-64	67	8	focusing	focus	VERB
bptjm-64	67	9	on	on	ADP
bptjm-64	67	10	the	the	DET
bptjm-64	67	11	er	er	INTJ
bptjm-64	67	12	stress	stress	NOUN
bptjm-64	67	13	pathway	pathway	NOUN
bptjm-64	67	14	,	,	PUNCT
bptjm-64	67	15	with	with	ADP
bptjm-64	67	16	a	a	DET
bptjm-64	67	17	particular	particular	ADJ
bptjm-64	67	18	emphasis	emphasis	NOUN
bptjm-64	67	19	on	on	ADP
bptjm-64	67	20	the	the	DET
bptjm-64	67	21	xbp1	xbp1	PROPN
bptjm-64	67	22	gene.21	gene.21	PROPN
bptjm-64	67	23	in	in	ADP
bptjm-64	67	24	a	a	DET
bptjm-64	67	25	2022	2022	NUM
bptjm-64	67	26	study	study	NOUN
bptjm-64	67	27	conducted	conduct	VERB
bptjm-64	67	28	by	by	ADP
bptjm-64	67	29	zundell	zundell	PROPN
bptjm-64	67	30	et	et	PROPN
bptjm-64	67	31	al	al	PROPN
bptjm-64	67	32	.	.	PROPN
bptjm-64	67	33	,	,	PUNCT
bptjm-64	67	34	investigating	investigate	VERB
bptjm-64	67	35	ovarian	ovarian	ADJ
bptjm-64	67	36	clear	clear	ADJ
bptjm-64	67	37	cell	cell	NOUN
bptjm-64	67	38	carcinomas	carcinoma	NOUN
bptjm-64	67	39	(	(	PUNCT
bptjm-64	67	40	occc	occc	PROPN
bptjm-64	67	41	)	)	PUNCT
bptjm-64	67	42	,	,	PUNCT
bptjm-64	67	43	it	it	PRON
bptjm-64	67	44	was	be	AUX
bptjm-64	67	45	discovered	discover	VERB
bptjm-64	67	46	that	that	SCONJ
bptjm-64	67	47	the	the	DET
bptjm-64	67	48	arid1a	arid1a	PROPN
bptjm-64	67	49	gene	gene	NOUN
bptjm-64	67	50	,	,	PUNCT
bptjm-64	67	51	responsible	responsible	ADJ
bptjm-64	67	52	for	for	ADP
bptjm-64	67	53	epigenetically	epigenetically	ADV
bptjm-64	67	54	regulating	regulate	VERB
bptjm-64	67	55	gene	gene	NOUN
bptjm-64	67	56	expression	expression	NOUN
bptjm-64	67	57	via	via	ADP
bptjm-64	67	58	the	the	DET
bptjm-64	67	59	swi	swi	PROPN
bptjm-64	67	60	/	/	SYM
bptjm-64	67	61	snf	snf	PROPN
bptjm-64	67	62	chromatin	chromatin	NOUN
bptjm-64	67	63	remodeling	remodeling	NOUN
bptjm-64	67	64	complex	complex	NOUN
bptjm-64	67	65	,	,	PUNCT
bptjm-64	67	66	is	be	AUX
bptjm-64	67	67	mutated	mutate	VERB
bptjm-64	67	68	in	in	ADP
bptjm-64	67	69	over	over	ADP
bptjm-64	67	70	50	50	NUM
bptjm-64	67	71	%	%	NOUN
bptjm-64	67	72	of	of	ADP
bptjm-64	67	73	occcs	occcs	PROPN
bptjm-64	67	74	.	.	PUNCT
bptjm-64	68	1	this	this	DET
bptjm-64	68	2	mutation	mutation	NOUN
bptjm-64	68	3	results	result	VERB
bptjm-64	68	4	in	in	ADP
bptjm-64	68	5	inadequate	inadequate	ADJ
bptjm-64	68	6	expression	expression	NOUN
bptjm-64	68	7	of	of	ADP
bptjm-64	68	8	arid1a	arid1a	PROPN
bptjm-64	68	9	protein	protein	NOUN
bptjm-64	68	10	,	,	PUNCT
bptjm-64	68	11	leading	lead	VERB
bptjm-64	68	12	to	to	ADP
bptjm-64	68	13	advanced	advanced	ADJ
bptjm-64	68	14	-	-	PUNCT
bptjm-64	68	15	stage	stage	NOUN
bptjm-64	68	16	disease	disease	NOUN
bptjm-64	68	17	and	and	CCONJ
bptjm-64	68	18	early	early	ADJ
bptjm-64	68	19	recurrence.21	recurrence.21	NOUN
bptjm-64	68	20	this	this	DET
bptjm-64	68	21	element	element	NOUN
bptjm-64	68	22	plays	play	VERB
bptjm-64	68	23	a	a	DET
bptjm-64	68	24	vital	vital	ADJ
bptjm-64	68	25	role	role	NOUN
bptjm-64	68	26	by	by	ADP
bptjm-64	68	27	transcriptionally	transcriptionally	ADV
bptjm-64	68	28	inhibiting	inhibit	VERB
bptjm-64	68	29	the	the	DET
bptjm-64	68	30	ire1𝛂-xbp1	ire1𝛂-xbp1	NOUN
bptjm-64	68	31	pathway	pathway	NOUN
bptjm-64	68	32	of	of	ADP
bptjm-64	68	33	the	the	DET
bptjm-64	68	34	er	er	INTJ
bptjm-64	68	35	stress	stress	NOUN
bptjm-64	68	36	response	response	NOUN
bptjm-64	68	37	.	.	PUNCT
bptjm-64	69	1	their	their	PRON
bptjm-64	69	2	research	research	NOUN
bptjm-64	69	3	using	use	VERB
bptjm-64	69	4	mouse	mouse	NOUN
bptjm-64	69	5	models	model	NOUN
bptjm-64	69	6	indicates	indicate	VERB
bptjm-64	69	7	that	that	SCONJ
bptjm-64	69	8	disabling	disable	VERB
bptjm-64	69	9	xbp1	xbp1	PROPN
bptjm-64	69	10	and	and	CCONJ
bptjm-64	69	11	inhibiting	inhibit	VERB
bptjm-64	69	12	the	the	DET
bptjm-64	69	13	ire1𝛂/xbp1	ire1𝛂/xbp1	PROPN
bptjm-64	69	14	pathways	pathway	NOUN
bptjm-64	69	15	signi	signi	PROPN
bptjm-64	69	16	�	�	PROPN
bptjm-64	69	17	cantly	cantly	ADV
bptjm-64	69	18	enhances	enhance	VERB
bptjm-64	69	19	the	the	DET
bptjm-64	69	20	survival	survival	NOUN
bptjm-64	69	21	rate	rate	NOUN
bptjm-64	69	22	of	of	ADP
bptjm-64	69	23	mice	mouse	NOUN
bptjm-64	69	24	with	with	ADP
bptjm-64	69	25	occc	occc	NOUN
bptjm-64	69	26	,	,	PUNCT
bptjm-64	69	27	as	as	SCONJ
bptjm-64	69	28	it	it	PRON
bptjm-64	69	29	suppresses	suppress	VERB
bptjm-64	69	30	the	the	DET
bptjm-64	69	31	growth	growth	NOUN
bptjm-64	69	32	of	of	ADP
bptjm-64	69	33	arid1a	arid1a	PROPN
bptjm-64	69	34	mutant	mutant	NOUN
bptjm-64	69	35	occc	occc	NOUN
bptjm-64	69	36	cells.21	cells.21	VERB
bptjm-64	69	37	in	in	ADP
bptjm-64	69	38	the	the	DET
bptjm-64	69	39	face	face	NOUN
bptjm-64	69	40	of	of	ADP
bptjm-64	69	41	er	er	INTJ
bptjm-64	69	42	stress	stress	NOUN
bptjm-64	69	43	,	,	PUNCT
bptjm-64	69	44	the	the	DET
bptjm-64	69	45	ire1-𝛂	ire1-𝛂	ADJ
bptjm-64	69	46	component	component	NOUN
bptjm-64	69	47	,	,	PUNCT
bptjm-64	69	48	a	a	DET
bptjm-64	69	49	type	type	NOUN
bptjm-64	69	50	of	of	ADP
bptjm-64	69	51	unfolded	unfold	VERB
bptjm-64	69	52	protein	protein	NOUN
bptjm-64	69	53	response	response	NOUN
bptjm-64	69	54	(	(	PUNCT
bptjm-64	69	55	upr	upr	NOUN
bptjm-64	69	56	)	)	PUNCT
bptjm-64	69	57	,	,	PUNCT
bptjm-64	69	58	undergoes	undergo	VERB
bptjm-64	69	59	a	a	DET
bptjm-64	69	60	structural	structural	ADJ
bptjm-64	69	61	change	change	NOUN
bptjm-64	69	62	,	,	PUNCT
bptjm-64	69	63	splicing	splice	VERB
bptjm-64	69	64	the	the	DET
bptjm-64	69	65	mrna	mrna	PROPN
bptjm-64	69	66	encoding	encode	VERB
bptjm-64	69	67	the	the	DET
bptjm-64	69	68	xbp1	xbp1	PROPN
bptjm-64	69	69	transcription	transcription	NOUN
bptjm-64	69	70	factor	factor	NOUN
bptjm-64	69	71	.	.	PUNCT
bptjm-64	70	1	this	this	DET
bptjm-64	70	2	splicing	splicing	NOUN
bptjm-64	70	3	facilitates	facilitate	VERB
bptjm-64	70	4	the	the	DET
bptjm-64	70	5	translation	translation	NOUN
bptjm-64	70	6	of	of	ADP
bptjm-64	70	7	xbp1	xbp1	PROPN
bptjm-64	70	8	,	,	PUNCT
bptjm-64	70	9	which	which	DET
bptjm-64	70	10	in	in	ADP
bptjm-64	70	11	turn	turn	NOUN
bptjm-64	70	12	aids	aids	PROPN
bptjm-64	70	13	cancer	cancer	NOUN
bptjm-64	70	14	cell	cell	NOUN
bptjm-64	70	15	survival	survival	NOUN
bptjm-64	70	16	by	by	ADP
bptjm-64	70	17	resolving	resolve	VERB
bptjm-64	70	18	er	er	INTJ
bptjm-64	70	19	stress.21	stress.21	NOUN
bptjm-64	70	20	er	er	INTJ
bptjm-64	70	21	stress	stress	NOUN
bptjm-64	70	22	itself	itself	PRON
bptjm-64	70	23	fosters	foster	VERB
bptjm-64	70	24	the	the	DET
bptjm-64	70	25	survival	survival	NOUN
bptjm-64	70	26	of	of	ADP
bptjm-64	70	27	cancer	cancer	NOUN
bptjm-64	70	28	cells	cell	NOUN
bptjm-64	70	29	by	by	ADP
bptjm-64	70	30	activating	activate	VERB
bptjm-64	70	31	adaptive	adaptive	ADJ
bptjm-64	70	32	programs	program	NOUN
bptjm-64	70	33	through	through	ADP
bptjm-64	70	34	the	the	DET
bptjm-64	70	35	unfolded	unfolded	ADJ
bptjm-64	70	36	protein	protein	NOUN
bptjm-64	70	37	response	response	NOUN
bptjm-64	70	38	(	(	PUNCT
bptjm-64	70	39	upr	upr	NOUN
bptjm-64	70	40	)	)	PUNCT
bptjm-64	70	41	once	once	ADV
bptjm-64	70	42	detected	detect	VERB
bptjm-64	70	43	.	.	PUNCT
bptjm-64	71	1	berkeley	berkeley	PROPN
bptjm-64	71	2	pharma	pharma	PROPN
bptjm-64	71	3	tech	tech	PROPN
bptjm-64	71	4	journal	journal	NOUN
bptjm-64	71	5	of	of	ADP
bptjm-64	71	6	medicine	medicine	NOUN
bptjm-64	71	7	|	|	ADV
bptjm-64	71	8	122	122	NUM
bptjm-64	71	9	consequently	consequently	ADV
bptjm-64	71	10	,	,	PUNCT
bptjm-64	71	11	inhibiting	inhibit	VERB
bptjm-64	71	12	the	the	DET
bptjm-64	71	13	upr	upr	NOUN
bptjm-64	71	14	is	be	AUX
bptjm-64	71	15	emerging	emerge	VERB
bptjm-64	71	16	as	as	ADP
bptjm-64	71	17	a	a	DET
bptjm-64	71	18	therapeutic	therapeutic	ADJ
bptjm-64	71	19	strategy	strategy	NOUN
bptjm-64	71	20	for	for	ADP
bptjm-64	71	21	cancers	cancer	NOUN
bptjm-64	71	22	characterized	characterize	VERB
bptjm-64	71	23	by	by	ADP
bptjm-64	71	24	heightened	heighten	VERB
bptjm-64	71	25	er	er	INTJ
bptjm-64	71	26	stress	stress	NOUN
bptjm-64	71	27	response.21	response.21	NOUN
bptjm-64	71	28	in	in	ADP
bptjm-64	71	29	this	this	DET
bptjm-64	71	30	study	study	NOUN
bptjm-64	71	31	,	,	PUNCT
bptjm-64	71	32	the	the	DET
bptjm-64	71	33	e	e	PROPN
bptjm-64	71	34	�	�	PROPN
bptjm-64	71	35	cacy	cacy	NOUN
bptjm-64	71	36	of	of	ADP
bptjm-64	71	37	a	a	DET
bptjm-64	71	38	therapeutic	therapeutic	ADJ
bptjm-64	71	39	intervention	intervention	NOUN
bptjm-64	71	40	targeting	target	VERB
bptjm-64	71	41	the	the	DET
bptjm-64	71	42	ire1𝛂	ire1𝛂	PROPN
bptjm-64	71	43	rnase	rnase	PROPN
bptjm-64	71	44	,	,	PUNCT
bptjm-64	71	45	b	b	NOUN
bptjm-64	71	46	-	-	PUNCT
bptjm-64	71	47	i09	i09	NOUN
bptjm-64	71	48	,	,	PUNCT
bptjm-64	71	49	was	be	AUX
bptjm-64	71	50	examined	examine	VERB
bptjm-64	71	51	.	.	PUNCT
bptjm-64	72	1	by	by	ADP
bptjm-64	72	2	inhibiting	inhibit	VERB
bptjm-64	72	3	ire1𝛂	ire1𝛂	PROPN
bptjm-64	72	4	rnase	rnase	PROPN
bptjm-64	72	5	activity	activity	NOUN
bptjm-64	72	6	,	,	PUNCT
bptjm-64	72	7	b	b	X
bptjm-64	72	8	-	-	PUNCT
bptjm-64	72	9	i09	i09	NOUN
bptjm-64	72	10	e	e	NOUN
bptjm-64	72	11	�	�	NOUN
bptjm-64	72	12	ectively	ectively	ADV
bptjm-64	72	13	suppressed	suppress	VERB
bptjm-64	72	14	the	the	DET
bptjm-64	72	15	growth	growth	NOUN
bptjm-64	72	16	of	of	ADP
bptjm-64	72	17	arid1a	arid1a	NOUN
bptjm-64	72	18	-	-	PUNCT
bptjm-64	72	19	activated	activate	VERB
bptjm-64	72	20	cells	cell	NOUN
bptjm-64	72	21	in	in	ADP
bptjm-64	72	22	ovarian	ovarian	ADJ
bptjm-64	72	23	clear	clear	ADJ
bptjm-64	72	24	cell	cell	NOUN
bptjm-64	72	25	carcinomas	carcinoma	NOUN
bptjm-64	72	26	(	(	PUNCT
bptjm-64	72	27	occcs	occcs	PROPN
bptjm-64	72	28	)	)	PUNCT
bptjm-64	72	29	,	,	PUNCT
bptjm-64	72	30	indicating	indicate	VERB
bptjm-64	72	31	the	the	DET
bptjm-64	72	32	potential	potential	NOUN
bptjm-64	72	33	of	of	ADP
bptjm-64	72	34	targeting	target	VERB
bptjm-64	72	35	the	the	DET
bptjm-64	72	36	ire1𝛂-xbp1	ire1𝛂-xbp1	NOUN
bptjm-64	72	37	axis	axis	NOUN
bptjm-64	72	38	of	of	ADP
bptjm-64	72	39	the	the	DET
bptjm-64	72	40	er	er	INTJ
bptjm-64	72	41	stress	stress	NOUN
bptjm-64	72	42	response	response	NOUN
bptjm-64	72	43	as	as	ADP
bptjm-64	72	44	a	a	DET
bptjm-64	72	45	promising	promising	ADJ
bptjm-64	72	46	approach	approach	NOUN
bptjm-64	72	47	for	for	ADP
bptjm-64	72	48	treating	treat	VERB
bptjm-64	72	49	arid1a	arid1a	PROPN
bptjm-64	72	50	mutant	mutant	ADJ
bptjm-64	72	51	occcs.21	occcs.21	NOUN
bptjm-64	72	52	a	a	DET
bptjm-64	72	53	study	study	NOUN
bptjm-64	72	54	by	by	ADP
bptjm-64	72	55	ma	ma	PROPN
bptjm-64	72	56	et	et	PROPN
bptjm-64	72	57	al	al	PROPN
bptjm-64	72	58	.	.	PROPN
bptjm-64	72	59	illustrated	illustrate	VERB
bptjm-64	72	60	the	the	DET
bptjm-64	72	61	role	role	NOUN
bptjm-64	72	62	of	of	ADP
bptjm-64	72	63	cholesterol	cholesterol	NOUN
bptjm-64	72	64	,	,	PUNCT
bptjm-64	72	65	the	the	DET
bptjm-64	72	66	primary	primary	ADJ
bptjm-64	72	67	sterol	sterol	NOUN
bptjm-64	72	68	distributed	distribute	VERB
bptjm-64	72	69	throughout	throughout	ADP
bptjm-64	72	70	the	the	DET
bptjm-64	72	71	human	human	ADJ
bptjm-64	72	72	body	body	NOUN
bptjm-64	72	73	,	,	PUNCT
bptjm-64	72	74	in	in	ADP
bptjm-64	72	75	the	the	DET
bptjm-64	72	76	er	er	INTJ
bptjm-64	72	77	stress	stress	NOUN
bptjm-64	72	78	-	-	PUNCT
bptjm-64	72	79	xbp1	xbp1	NOUN
bptjm-64	72	80	pathway.22	pathway.22	NOUN
bptjm-64	72	81	through	through	ADP
bptjm-64	72	82	staining	stain	VERB
bptjm-64	72	83	techniques	technique	NOUN
bptjm-64	72	84	to	to	PART
bptjm-64	72	85	observe	observe	VERB
bptjm-64	72	86	cholesterol	cholesterol	NOUN
bptjm-64	72	87	levels	level	NOUN
bptjm-64	72	88	in	in	ADP
bptjm-64	72	89	tumor	tumor	NOUN
bptjm-64	72	90	-	-	PUNCT
bptjm-64	72	91	in	in	ADP
bptjm-64	72	92	�	�	PROPN
bptjm-64	72	93	ltrating	ltrating	NOUN
bptjm-64	72	94	t	t	NOUN
bptjm-64	72	95	cells	cell	NOUN
bptjm-64	72	96	in	in	ADP
bptjm-64	72	97	mice	mouse	NOUN
bptjm-64	72	98	,	,	PUNCT
bptjm-64	72	99	researchers	researcher	NOUN
bptjm-64	72	100	found	find	VERB
bptjm-64	72	101	that	that	SCONJ
bptjm-64	72	102	elevated	elevated	ADJ
bptjm-64	72	103	cholesterol	cholesterol	NOUN
bptjm-64	72	104	content	content	NOUN
bptjm-64	72	105	triggers	trigger	VERB
bptjm-64	72	106	cd8	cd8	PROPN
bptjm-64	72	107	+	+	PROPN
bptjm-64	72	108	t	t	PROPN
bptjm-64	72	109	cell	cell	NOUN
bptjm-64	72	110	exhaustion	exhaustion	NOUN
bptjm-64	72	111	via	via	ADP
bptjm-64	72	112	the	the	DET
bptjm-64	72	113	er	er	INTJ
bptjm-64	72	114	stress	stress	NOUN
bptjm-64	72	115	-	-	PUNCT
bptjm-64	72	116	xbp1	xbp1	PROPN
bptjm-64	72	117	pathway.22	pathway.22	NOUN
bptjm-64	72	118	inhibiting	inhibit	VERB
bptjm-64	72	119	the	the	DET
bptjm-64	72	120	xbp1	xbp1	PROPN
bptjm-64	72	121	pathway	pathway	NOUN
bptjm-64	72	122	or	or	CCONJ
bptjm-64	72	123	reducing	reduce	VERB
bptjm-64	72	124	cholesterol	cholesterol	NOUN
bptjm-64	72	125	levels	level	NOUN
bptjm-64	72	126	in	in	ADP
bptjm-64	72	127	cd8	cd8	PROPN
bptjm-64	72	128	+	+	PROPN
bptjm-64	72	129	t	t	PROPN
bptjm-64	72	130	cells	cell	NOUN
bptjm-64	72	131	restored	restore	VERB
bptjm-64	72	132	normal	normal	ADJ
bptjm-64	72	133	antitumor	antitumor	PROPN
bptjm-64	72	134	function	function	NOUN
bptjm-64	72	135	,	,	PUNCT
bptjm-64	72	136	while	while	SCONJ
bptjm-64	72	137	increased	increase	VERB
bptjm-64	72	138	cholesterol	cholesterol	NOUN
bptjm-64	72	139	was	be	AUX
bptjm-64	72	140	consistently	consistently	ADV
bptjm-64	72	141	linked	link	VERB
bptjm-64	72	142	to	to	ADP
bptjm-64	72	143	elevated	elevated	ADJ
bptjm-64	72	144	pd-1	pd-1	ADP
bptjm-64	72	145	expression	expression	NOUN
bptjm-64	72	146	on	on	ADP
bptjm-64	72	147	tumor	tumor	NOUN
bptjm-64	72	148	-	-	PUNCT
bptjm-64	72	149	in	in	ADP
bptjm-64	72	150	�	�	PROPN
bptjm-64	72	151	ltrating	ltrating	NOUN
bptjm-64	72	152	t	t	PROPN
bptjm-64	72	153	cells.22	cells.22	VERB
bptjm-64	72	154	similar	similar	ADJ
bptjm-64	72	155	patterns	pattern	NOUN
bptjm-64	72	156	were	be	AUX
bptjm-64	72	157	observed	observe	VERB
bptjm-64	72	158	in	in	ADP
bptjm-64	72	159	human	human	ADJ
bptjm-64	72	160	colon	colon	NOUN
bptjm-64	72	161	cancer	cancer	NOUN
bptjm-64	72	162	and	and	CCONJ
bptjm-64	72	163	myeloma	myeloma	NOUN
bptjm-64	72	164	samples	sample	NOUN
bptjm-64	72	165	,	,	PUNCT
bptjm-64	72	166	underscoring	underscore	VERB
bptjm-64	72	167	the	the	DET
bptjm-64	72	168	signi	signi	NOUN
bptjm-64	72	169	�	�	PROPN
bptjm-64	72	170	cance	cance	NOUN
bptjm-64	72	171	of	of	ADP
bptjm-64	72	172	cholesterol	cholesterol	NOUN
bptjm-64	72	173	content	content	NOUN
bptjm-64	72	174	in	in	ADP
bptjm-64	72	175	t	t	PROPN
bptjm-64	72	176	cell	cell	NOUN
bptjm-64	72	177	exhaustion.22	exhaustion.22	NOUN
bptjm-64	72	178	3.5	3.5	NUM
bptjm-64	72	179	vegf	vegf	PROPN
bptjm-64	72	180	/	/	SYM
bptjm-64	72	181	vegf	vegf	PROPN
bptjm-64	72	182	-	-	PUNCT
bptjm-64	72	183	a	a	PRON
bptjm-64	72	184	:	:	PUNCT
bptjm-64	72	185	vascular	vascular	ADJ
bptjm-64	72	186	endothelial	endothelial	ADJ
bptjm-64	72	187	growth	growth	NOUN
bptjm-64	72	188	factors	factor	NOUN
bptjm-64	72	189	(	(	PUNCT
bptjm-64	72	190	vegfs	vegfs	NOUN
bptjm-64	72	191	)	)	PUNCT
bptjm-64	72	192	are	be	AUX
bptjm-64	72	193	signaling	signal	VERB
bptjm-64	72	194	proteins	protein	NOUN
bptjm-64	72	195	crucially	crucially	ADV
bptjm-64	72	196	involved	involve	VERB
bptjm-64	72	197	in	in	ADP
bptjm-64	72	198	the	the	DET
bptjm-64	72	199	microvasculature	microvasculature	NOUN
bptjm-64	72	200	of	of	ADP
bptjm-64	72	201	tumors	tumor	NOUN
bptjm-64	72	202	,	,	PUNCT
bptjm-64	72	203	the	the	DET
bptjm-64	72	204	suppression	suppression	NOUN
bptjm-64	72	205	of	of	ADP
bptjm-64	72	206	immune	immune	ADJ
bptjm-64	72	207	cells	cell	NOUN
bptjm-64	72	208	,	,	PUNCT
bptjm-64	72	209	and	and	CCONJ
bptjm-64	72	210	the	the	DET
bptjm-64	72	211	promotion	promotion	NOUN
bptjm-64	72	212	of	of	ADP
bptjm-64	72	213	immunosuppression	immunosuppression	NOUN
bptjm-64	72	214	,	,	PUNCT
bptjm-64	72	215	both	both	CCONJ
bptjm-64	72	216	locally	locally	ADV
bptjm-64	72	217	and	and	CCONJ
bptjm-64	72	218	systemically	systemically	ADV
bptjm-64	72	219	,	,	PUNCT
bptjm-64	72	220	in	in	ADP
bptjm-64	72	221	cancer.19	cancer.19	NOUN
bptjm-64	72	222	these	these	DET
bptjm-64	72	223	proteins	protein	NOUN
bptjm-64	72	224	are	be	AUX
bptjm-64	72	225	predominantly	predominantly	ADV
bptjm-64	72	226	secreted	secrete	VERB
bptjm-64	72	227	by	by	ADP
bptjm-64	72	228	the	the	DET
bptjm-64	72	229	endothelial	endothelial	ADJ
bptjm-64	72	230	cells	cell	NOUN
bptjm-64	72	231	lining	line	VERB
bptjm-64	72	232	blood	blood	NOUN
bptjm-64	72	233	vessels	vessel	NOUN
bptjm-64	72	234	,	,	PUNCT
bptjm-64	72	235	with	with	ADP
bptjm-64	72	236	additional	additional	ADJ
bptjm-64	72	237	production	production	NOUN
bptjm-64	72	238	occurring	occur	VERB
bptjm-64	72	239	in	in	ADP
bptjm-64	72	240	immune	immune	ADJ
bptjm-64	72	241	cells	cell	NOUN
bptjm-64	72	242	within	within	ADP
bptjm-64	72	243	the	the	DET
bptjm-64	72	244	tumor	tumor	NOUN
bptjm-64	72	245	microenvironment	microenvironment	NOUN
bptjm-64	72	246	(	(	PUNCT
bptjm-64	72	247	tme).19	tme).19	ADP
bptjm-64	72	248	vegfs	vegfs	NOUN
bptjm-64	72	249	play	play	VERB
bptjm-64	72	250	a	a	DET
bptjm-64	72	251	pivotal	pivotal	ADJ
bptjm-64	72	252	role	role	NOUN
bptjm-64	72	253	in	in	ADP
bptjm-64	72	254	fostering	foster	VERB
bptjm-64	72	255	tumor	tumor	NOUN
bptjm-64	72	256	development	development	NOUN
bptjm-64	72	257	and	and	CCONJ
bptjm-64	72	258	progression	progression	NOUN
bptjm-64	72	259	by	by	ADP
bptjm-64	72	260	interacting	interact	VERB
bptjm-64	72	261	with	with	ADP
bptjm-64	72	262	receptors	receptor	NOUN
bptjm-64	72	263	on	on	ADP
bptjm-64	72	264	tumor	tumor	NOUN
bptjm-64	72	265	cells	cell	NOUN
bptjm-64	72	266	through	through	ADP
bptjm-64	72	267	autocrine	autocrine	NOUN
bptjm-64	72	268	and	and	CCONJ
bptjm-64	72	269	paracrine	paracrine	VERB
bptjm-64	72	270	signaling	signal	VERB
bptjm-64	72	271	pathways	pathway	NOUN
bptjm-64	72	272	.	.	PUNCT
bptjm-64	73	1	among	among	ADP
bptjm-64	73	2	them	they	PRON
bptjm-64	73	3	,	,	PUNCT
bptjm-64	73	4	vegf	vegf	PROPN
bptjm-64	73	5	-	-	PUNCT
bptjm-64	73	6	a	a	PRON
bptjm-64	73	7	primarily	primarily	ADV
bptjm-64	73	8	binds	bind	VERB
bptjm-64	73	9	to	to	ADP
bptjm-64	73	10	vegfr-2	vegfr-2	NUM
bptjm-64	73	11	,	,	PUNCT
bptjm-64	73	12	triggering	trigger	VERB
bptjm-64	73	13	the	the	DET
bptjm-64	73	14	proliferation	proliferation	NOUN
bptjm-64	73	15	and	and	CCONJ
bptjm-64	73	16	migration	migration	NOUN
bptjm-64	73	17	of	of	ADP
bptjm-64	73	18	endothelial	endothelial	ADJ
bptjm-64	73	19	cells	cell	NOUN
bptjm-64	73	20	,	,	PUNCT
bptjm-64	73	21	thereby	thereby	ADV
bptjm-64	73	22	facilitating	facilitate	VERB
bptjm-64	73	23	angiogenesis.19	angiogenesis.19	PROPN
bptjm-64	73	24	berkeley	berkeley	PROPN
bptjm-64	73	25	pharma	pharma	PROPN
bptjm-64	73	26	tech	tech	NOUN
bptjm-64	73	27	journal	journal	NOUN
bptjm-64	73	28	of	of	ADP
bptjm-64	73	29	medicine	medicine	NOUN
bptjm-64	73	30	|	|	ADV
bptjm-64	73	31	123	123	NUM
bptjm-64	73	32	vegf	vegf	NOUN
bptjm-64	73	33	-	-	PUNCT
bptjm-64	73	34	a	a	PRON
bptjm-64	73	35	boosts	boost	VERB
bptjm-64	73	36	the	the	DET
bptjm-64	73	37	expression	expression	NOUN
bptjm-64	73	38	of	of	ADP
bptjm-64	73	39	both	both	DET
bptjm-64	73	40	pd-1	pd-1	ADJ
bptjm-64	73	41	and	and	CCONJ
bptjm-64	73	42	ctla-4	ctla-4	NUM
bptjm-64	73	43	,	,	PUNCT
bptjm-64	73	44	dampening	dampen	VERB
bptjm-64	73	45	the	the	DET
bptjm-64	73	46	body	body	NOUN
bptjm-64	73	47	's	's	PART
bptjm-64	73	48	ability	ability	NOUN
bptjm-64	73	49	to	to	PART
bptjm-64	73	50	�	�	VERB
bptjm-64	73	51	ght	ght	PROPN
bptjm-64	73	52	tumors	tumor	NOUN
bptjm-64	73	53	and	and	CCONJ
bptjm-64	73	54	reducing	reduce	VERB
bptjm-64	73	55	the	the	DET
bptjm-64	73	56	activity	activity	NOUN
bptjm-64	73	57	of	of	ADP
bptjm-64	73	58	cd8	cd8	PROPN
bptjm-64	73	59	+	+	PROPN
bptjm-64	73	60	t	t	PROPN
bptjm-64	73	61	cells	cell	NOUN
bptjm-64	73	62	by	by	ADP
bptjm-64	73	63	transitioning	transition	VERB
bptjm-64	73	64	them	they	PRON
bptjm-64	73	65	from	from	ADP
bptjm-64	73	66	an	an	DET
bptjm-64	73	67	active	active	ADJ
bptjm-64	73	68	state	state	NOUN
bptjm-64	73	69	to	to	ADP
bptjm-64	73	70	an	an	DET
bptjm-64	73	71	exhausted	exhausted	ADJ
bptjm-64	73	72	one	one	NOUN
bptjm-64	73	73	,	,	PUNCT
bptjm-64	73	74	impairing	impair	VERB
bptjm-64	73	75	their	their	PRON
bptjm-64	73	76	normal	normal	ADJ
bptjm-64	73	77	function	function	NOUN
bptjm-64	73	78	.	.	PUNCT
bptjm-64	74	1	blocking	block	VERB
bptjm-64	74	2	vegf	vegf	PROPN
bptjm-64	74	3	with	with	ADP
bptjm-64	74	4	anti	anti	ADJ
bptjm-64	74	5	-	-	ADJ
bptjm-64	74	6	angiogenic	angiogenic	ADJ
bptjm-64	74	7	agents	agent	NOUN
bptjm-64	74	8	can	can	AUX
bptjm-64	74	9	reverse	reverse	VERB
bptjm-64	74	10	the	the	DET
bptjm-64	74	11	immune	immune	ADJ
bptjm-64	74	12	checkpoints	checkpoint	NOUN
bptjm-64	74	13	'	'	PART
bptjm-64	74	14	inhibitory	inhibitory	ADJ
bptjm-64	74	15	e	e	PROPN
bptjm-64	74	16	�	�	NOUN
bptjm-64	74	17	ects.19	ects.19	NOUN
bptjm-64	74	18	in	in	ADP
bptjm-64	74	19	a	a	DET
bptjm-64	74	20	phase	phase	NOUN
bptjm-64	74	21	i	i	PRON
bptjm-64	74	22	trial	trial	NOUN
bptjm-64	74	23	led	lead	VERB
bptjm-64	74	24	by	by	ADP
bptjm-64	74	25	daniel	daniel	PROPN
bptjm-64	74	26	chiu	chiu	PROPN
bptjm-64	74	27	et	et	PROPN
bptjm-64	74	28	al	al	PROPN
bptjm-64	74	29	.	.	PROPN
bptjm-64	74	30	,	,	PUNCT
bptjm-64	74	31	a	a	DET
bptjm-64	74	32	combination	combination	NOUN
bptjm-64	74	33	of	of	ADP
bptjm-64	74	34	anti	anti	ADJ
bptjm-64	74	35	-	-	ADJ
bptjm-64	74	36	pd-1	pd-1	ADJ
bptjm-64	74	37	therapy	therapy	NOUN
bptjm-64	74	38	and	and	CCONJ
bptjm-64	74	39	antiangiogenic	antiangiogenic	ADJ
bptjm-64	74	40	agents	agent	NOUN
bptjm-64	74	41	was	be	AUX
bptjm-64	74	42	used	use	VERB
bptjm-64	74	43	to	to	PART
bptjm-64	74	44	treat	treat	VERB
bptjm-64	74	45	glioblastoma	glioblastoma	NOUN
bptjm-64	74	46	,	,	PUNCT
bptjm-64	74	47	a	a	DET
bptjm-64	74	48	challenging	challenging	ADJ
bptjm-64	74	49	form	form	NOUN
bptjm-64	74	50	of	of	ADP
bptjm-64	74	51	brain	brain	NOUN
bptjm-64	74	52	cancer	cancer	NOUN
bptjm-64	74	53	known	know	VERB
bptjm-64	74	54	for	for	ADP
bptjm-64	74	55	its	its	PRON
bptjm-64	74	56	resistance	resistance	NOUN
bptjm-64	74	57	to	to	ADP
bptjm-64	74	58	ici	ici	NOUN
bptjm-64	74	59	therapy	therapy	NOUN
bptjm-64	74	60	.	.	PUNCT
bptjm-64	75	1	the	the	DET
bptjm-64	75	2	�	�	PROPN
bptjm-64	75	3	ndings	nding	NOUN
bptjm-64	75	4	revealed	reveal	VERB
bptjm-64	75	5	that	that	SCONJ
bptjm-64	75	6	this	this	DET
bptjm-64	75	7	combination	combination	NOUN
bptjm-64	75	8	treatment	treatment	NOUN
bptjm-64	75	9	was	be	AUX
bptjm-64	75	10	well	well	ADV
bptjm-64	75	11	tolerated	tolerate	VERB
bptjm-64	75	12	,	,	PUNCT
bptjm-64	75	13	safe	safe	ADJ
bptjm-64	75	14	,	,	PUNCT
bptjm-64	75	15	and	and	CCONJ
bptjm-64	75	16	did	do	AUX
bptjm-64	75	17	not	not	PART
bptjm-64	75	18	lead	lead	VERB
bptjm-64	75	19	to	to	ADP
bptjm-64	75	20	any	any	DET
bptjm-64	75	21	previously	previously	ADV
bptjm-64	75	22	unreported	unreported	ADJ
bptjm-64	75	23	adverse	adverse	ADJ
bptjm-64	75	24	events	event	NOUN
bptjm-64	75	25	.	.	PUNCT
bptjm-64	76	1	furthermore	furthermore	ADV
bptjm-64	76	2	,	,	PUNCT
bptjm-64	76	3	the	the	DET
bptjm-64	76	4	results	result	NOUN
bptjm-64	76	5	showed	show	VERB
bptjm-64	76	6	decreased	decrease	VERB
bptjm-64	76	7	levels	level	NOUN
bptjm-64	76	8	of	of	ADP
bptjm-64	76	9	vegf	vegf	PROPN
bptjm-64	76	10	-	-	PUNCT
bptjm-64	76	11	a	a	NOUN
bptjm-64	76	12	and	and	CCONJ
bptjm-64	76	13	other	other	ADJ
bptjm-64	76	14	angiogenic	angiogenic	ADJ
bptjm-64	76	15	factors	factor	NOUN
bptjm-64	76	16	in	in	ADP
bptjm-64	76	17	the	the	DET
bptjm-64	76	18	tumor	tumor	NOUN
bptjm-64	76	19	microenvironment	microenvironment	NOUN
bptjm-64	76	20	,	,	PUNCT
bptjm-64	76	21	underscoring	underscore	VERB
bptjm-64	76	22	the	the	DET
bptjm-64	76	23	relationship	relationship	NOUN
bptjm-64	76	24	between	between	ADP
bptjm-64	76	25	vegf	vegf	PROPN
bptjm-64	76	26	and	and	CCONJ
bptjm-64	76	27	pd-1	pd-1	ADV
bptjm-64	76	28	expression.16	expression.16	PROPN
bptjm-64	76	29	4	4	NUM
bptjm-64	76	30	.	.	PUNCT
bptjm-64	76	31	overcoming	overcome	VERB
bptjm-64	76	32	resistance	resistance	NOUN
bptjm-64	76	33	to	to	ADP
bptjm-64	76	34	immune	immune	ADJ
bptjm-64	76	35	checkpoint	checkpoint	NOUN
bptjm-64	76	36	blockade	blockade	NOUN
bptjm-64	76	37	although	although	SCONJ
bptjm-64	76	38	the	the	DET
bptjm-64	76	39	immune	immune	ADJ
bptjm-64	76	40	checkpoint	checkpoint	NOUN
bptjm-64	76	41	blockade	blockade	NOUN
bptjm-64	76	42	strategy	strategy	NOUN
bptjm-64	76	43	has	have	AUX
bptjm-64	76	44	shown	show	VERB
bptjm-64	76	45	e	e	NOUN
bptjm-64	76	46	�	�	NOUN
bptjm-64	76	47	cacy	cacy	NOUN
bptjm-64	76	48	in	in	ADP
bptjm-64	76	49	reviving	revive	VERB
bptjm-64	76	50	the	the	DET
bptjm-64	76	51	antitumor	antitumor	PROPN
bptjm-64	76	52	response	response	NOUN
bptjm-64	76	53	within	within	ADP
bptjm-64	76	54	tumor	tumor	NOUN
bptjm-64	76	55	-	-	PUNCT
bptjm-64	76	56	in	in	ADP
bptjm-64	76	57	�	�	NOUN
bptjm-64	76	58	ltrating	ltrating	NOUN
bptjm-64	76	59	lymphocytes	lymphocyte	NOUN
bptjm-64	76	60	(	(	PUNCT
bptjm-64	76	61	tils	til	NOUN
bptjm-64	76	62	)	)	PUNCT
bptjm-64	76	63	and	and	CCONJ
bptjm-64	76	64	cytotoxic	cytotoxic	ADJ
bptjm-64	76	65	t	t	NOUN
bptjm-64	76	66	cells	cell	NOUN
bptjm-64	76	67	,	,	PUNCT
bptjm-64	76	68	the	the	DET
bptjm-64	76	69	tumor	tumor	NOUN
bptjm-64	76	70	microenvironment	microenvironment	NOUN
bptjm-64	76	71	(	(	PUNCT
bptjm-64	76	72	tme	tme	NOUN
bptjm-64	76	73	)	)	PUNCT
bptjm-64	76	74	employs	employ	VERB
bptjm-64	76	75	adaptive	adaptive	ADJ
bptjm-64	76	76	resistance	resistance	NOUN
bptjm-64	76	77	mechanisms	mechanism	NOUN
bptjm-64	76	78	against	against	ADP
bptjm-64	76	79	this	this	DET
bptjm-64	76	80	therapy	therapy	NOUN
bptjm-64	76	81	.	.	PUNCT
bptjm-64	77	1	speci	speci	PROPN
bptjm-64	77	2	�	�	PROPN
bptjm-64	77	3	cally	cally	ADV
bptjm-64	77	4	,	,	PUNCT
bptjm-64	77	5	the	the	DET
bptjm-64	77	6	upregulation	upregulation	NOUN
bptjm-64	77	7	of	of	ADP
bptjm-64	77	8	immune	immune	ADJ
bptjm-64	77	9	checkpoints	checkpoint	NOUN
bptjm-64	77	10	such	such	ADJ
bptjm-64	77	11	as	as	ADP
bptjm-64	77	12	pd-1	pd-1	ADJ
bptjm-64	77	13	and	and	CCONJ
bptjm-64	77	14	ctla-4	ctla-4	NOUN
bptjm-64	77	15	in	in	ADP
bptjm-64	77	16	response	response	NOUN
bptjm-64	77	17	to	to	ADP
bptjm-64	77	18	targeted	target	VERB
bptjm-64	77	19	antibodies	antibody	NOUN
bptjm-64	77	20	can	can	AUX
bptjm-64	77	21	foster	foster	VERB
bptjm-64	77	22	this	this	DET
bptjm-64	77	23	adaptive	adaptive	ADJ
bptjm-64	77	24	resistance.14	resistance.14	NOUN
bptjm-64	77	25	moreover	moreover	ADV
bptjm-64	77	26	,	,	PUNCT
bptjm-64	77	27	the	the	DET
bptjm-64	77	28	tme	tme	NOUN
bptjm-64	77	29	utilizes	utilizes	ADJ
bptjm-64	77	30	evasion	evasion	NOUN
bptjm-64	77	31	tactics	tactic	NOUN
bptjm-64	77	32	,	,	PUNCT
bptjm-64	77	33	such	such	ADJ
bptjm-64	77	34	as	as	ADP
bptjm-64	77	35	enhancing	enhance	VERB
bptjm-64	77	36	pd-1	pd-1	ADP
bptjm-64	77	37	expression	expression	NOUN
bptjm-64	77	38	in	in	ADP
bptjm-64	77	39	response	response	NOUN
bptjm-64	77	40	to	to	ADP
bptjm-64	77	41	t	t	NOUN
bptjm-64	77	42	cell	cell	NOUN
bptjm-64	77	43	attacks	attack	NOUN
bptjm-64	77	44	,	,	PUNCT
bptjm-64	77	45	leading	lead	VERB
bptjm-64	77	46	to	to	ADP
bptjm-64	77	47	the	the	DET
bptjm-64	77	48	functional	functional	ADJ
bptjm-64	77	49	impairment	impairment	NOUN
bptjm-64	77	50	of	of	ADP
bptjm-64	77	51	tils.13,17	tils.13,17	NOUN
bptjm-64	77	52	additionally	additionally	ADV
bptjm-64	77	53	,	,	PUNCT
bptjm-64	77	54	the	the	DET
bptjm-64	77	55	di	di	PROPN
bptjm-64	77	56	�	�	PROPN
bptjm-64	77	57	erentiation	erentiation	NOUN
bptjm-64	77	58	of	of	ADP
bptjm-64	77	59	cd8	cd8	PROPN
bptjm-64	77	60	+	+	PROPN
bptjm-64	77	61	t	t	PROPN
bptjm-64	77	62	cells	cell	NOUN
bptjm-64	77	63	poses	pose	VERB
bptjm-64	77	64	a	a	DET
bptjm-64	77	65	signi	signi	ADJ
bptjm-64	77	66	�	�	NOUN
bptjm-64	77	67	cant	cant	NOUN
bptjm-64	77	68	challenge	challenge	NOUN
bptjm-64	77	69	,	,	PUNCT
bptjm-64	77	70	as	as	SCONJ
bptjm-64	77	71	tils	til	NOUN
bptjm-64	77	72	develop	develop	VERB
bptjm-64	77	73	resistance	resistance	NOUN
bptjm-64	77	74	to	to	ADP
bptjm-64	77	75	antitumor	antitumor	PROPN
bptjm-64	77	76	treatments	treatment	NOUN
bptjm-64	77	77	,	,	PUNCT
bptjm-64	77	78	resulting	result	VERB
bptjm-64	77	79	in	in	ADP
bptjm-64	77	80	a	a	DET
bptjm-64	77	81	diverse	diverse	ADJ
bptjm-64	77	82	cd8	cd8	PROPN
bptjm-64	77	83	+	+	PROPN
bptjm-64	77	84	t	t	PROPN
bptjm-64	77	85	cell	cell	NOUN
bptjm-64	77	86	subset.17	subset.17	PRON
bptjm-64	77	87	researchers	researcher	NOUN
bptjm-64	77	88	are	be	AUX
bptjm-64	77	89	exploring	explore	VERB
bptjm-64	77	90	combination	combination	NOUN
bptjm-64	77	91	therapies	therapy	NOUN
bptjm-64	77	92	,	,	PUNCT
bptjm-64	77	93	pairing	pair	VERB
bptjm-64	77	94	immunotherapy	immunotherapy	NOUN
bptjm-64	77	95	with	with	ADP
bptjm-64	77	96	chemotherapy	chemotherapy	NOUN
bptjm-64	77	97	or	or	CCONJ
bptjm-64	77	98	radiation	radiation	NOUN
bptjm-64	77	99	therapy	therapy	NOUN
bptjm-64	77	100	,	,	PUNCT
bptjm-64	77	101	to	to	PART
bptjm-64	77	102	address	address	VERB
bptjm-64	77	103	malignant	malignant	ADJ
bptjm-64	77	104	tumors	tumor	NOUN
bptjm-64	77	105	.	.	PUNCT
bptjm-64	78	1	in	in	ADP
bptjm-64	78	2	a	a	DET
bptjm-64	78	3	study	study	NOUN
bptjm-64	78	4	by	by	ADP
bptjm-64	78	5	feng	feng	PROPN
bptjm-64	78	6	y.	y.	PROPN
bptjm-64	78	7	et	et	PROPN
bptjm-64	78	8	al	al	PROPN
bptjm-64	78	9	.	.	PROPN
bptjm-64	78	10	,	,	PUNCT
bptjm-64	78	11	a	a	DET
bptjm-64	78	12	dual	dual	ADJ
bptjm-64	78	13	gene	gene	NOUN
bptjm-64	78	14	therapy	therapy	NOUN
bptjm-64	78	15	approach	approach	NOUN
bptjm-64	78	16	was	be	AUX
bptjm-64	78	17	investigated	investigate	VERB
bptjm-64	78	18	to	to	PART
bptjm-64	78	19	counter	counter	VERB
bptjm-64	78	20	adaptive	adaptive	ADJ
bptjm-64	78	21	resistance	resistance	NOUN
bptjm-64	78	22	to	to	ADP
bptjm-64	78	23	immune	immune	ADJ
bptjm-64	78	24	checkpoint	checkpoint	NOUN
bptjm-64	78	25	blockade	blockade	NOUN
bptjm-64	78	26	therapy	therapy	NOUN
bptjm-64	78	27	in	in	ADP
bptjm-64	78	28	both	both	CCONJ
bptjm-64	78	29	cd4	cd4	PROPN
bptjm-64	78	30	+	+	PROPN
bptjm-64	78	31	and	and	CCONJ
bptjm-64	78	32	cd8	cd8	PROPN
bptjm-64	78	33	+	+	PROPN
bptjm-64	78	34	t	t	NOUN
bptjm-64	78	35	cells	cell	NOUN
bptjm-64	78	36	.	.	PUNCT
bptjm-64	79	1	the	the	DET
bptjm-64	79	2	scientists	scientist	NOUN
bptjm-64	79	3	developed	develop	VERB
bptjm-64	79	4	a	a	DET
bptjm-64	79	5	dual	dual	ADJ
bptjm-64	79	6	gene	gene	NOUN
bptjm-64	79	7	delivery	delivery	NOUN
bptjm-64	79	8	system	system	NOUN
bptjm-64	79	9	aimed	aim	VERB
bptjm-64	79	10	at	at	ADP
bptjm-64	79	11	eliminating	eliminate	VERB
bptjm-64	79	12	tumor	tumor	NOUN
bptjm-64	79	13	adaptive	adaptive	ADJ
bptjm-64	79	14	resistance	resistance	NOUN
bptjm-64	79	15	and	and	CCONJ
bptjm-64	79	16	restoring	restore	VERB
bptjm-64	79	17	t	t	NOUN
bptjm-64	79	18	cell	cell	NOUN
bptjm-64	79	19	function	function	NOUN
bptjm-64	79	20	by	by	ADP
bptjm-64	79	21	modulating	modulate	VERB
bptjm-64	79	22	the	the	DET
bptjm-64	79	23	expression	expression	NOUN
bptjm-64	79	24	of	of	ADP
bptjm-64	79	25	vegf	vegf	PROPN
bptjm-64	79	26	-	-	PUNCT
bptjm-64	79	27	a	a	PROPN
bptjm-64	79	28	and	and	CCONJ
bptjm-64	79	29	pd	pd	PROPN
bptjm-64	79	30	-	-	PROPN
bptjm-64	79	31	l1	l1	PROPN
bptjm-64	79	32	proteins.14	proteins.14	PROPN
bptjm-64	79	33	gene	gene	NOUN
bptjm-64	79	34	-	-	PUNCT
bptjm-64	79	35	silencing	silence	VERB
bptjm-64	79	36	techniques	technique	NOUN
bptjm-64	79	37	were	be	AUX
bptjm-64	79	38	employed	employ	VERB
bptjm-64	79	39	to	to	PART
bptjm-64	79	40	decrease	decrease	VERB
bptjm-64	79	41	vegf	vegf	PROPN
bptjm-64	79	42	-	-	PUNCT
bptjm-64	79	43	a	a	DET
bptjm-64	79	44	expression	expression	NOUN
bptjm-64	79	45	in	in	ADP
bptjm-64	79	46	the	the	DET
bptjm-64	79	47	tme	tme	NOUN
bptjm-64	79	48	,	,	PUNCT
bptjm-64	79	49	reducing	reduce	VERB
bptjm-64	79	50	angiogenic	angiogenic	ADJ
bptjm-64	79	51	activity	activity	NOUN
bptjm-64	79	52	and	and	CCONJ
bptjm-64	79	53	blocking	block	VERB
bptjm-64	79	54	pd	pd	PROPN
bptjm-64	79	55	-	-	PUNCT
bptjm-64	79	56	l1	l1	PROPN
bptjm-64	79	57	immune	immune	PROPN
bptjm-64	79	58	berkeley	berkeley	PROPN
bptjm-64	79	59	pharma	pharma	PROPN
bptjm-64	79	60	tech	tech	NOUN
bptjm-64	79	61	journal	journal	NOUN
bptjm-64	79	62	of	of	ADP
bptjm-64	79	63	medicine	medicine	NOUN
bptjm-64	79	64	|	|	ADV
bptjm-64	79	65	124	124	NUM
bptjm-64	79	66	checkpoint	checkpoint	NOUN
bptjm-64	79	67	.	.	PUNCT
bptjm-64	80	1	the	the	DET
bptjm-64	80	2	�	�	PROPN
bptjm-64	80	3	ndings	nding	NOUN
bptjm-64	80	4	demonstrated	demonstrate	VERB
bptjm-64	80	5	an	an	DET
bptjm-64	80	6	increase	increase	NOUN
bptjm-64	80	7	in	in	ADP
bptjm-64	80	8	the	the	DET
bptjm-64	80	9	number	number	NOUN
bptjm-64	80	10	of	of	ADP
bptjm-64	80	11	cd8	cd8	PROPN
bptjm-64	80	12	+	+	PROPN
bptjm-64	80	13	t	t	PROPN
bptjm-64	80	14	cells	cell	NOUN
bptjm-64	80	15	expressing	express	VERB
bptjm-64	80	16	granzymes	granzyme	NOUN
bptjm-64	80	17	b	b	NOUN
bptjm-64	80	18	,	,	PUNCT
bptjm-64	80	19	leading	lead	VERB
bptjm-64	80	20	to	to	ADP
bptjm-64	80	21	inhibited	inhibit	VERB
bptjm-64	80	22	tumor	tumor	NOUN
bptjm-64	80	23	growth.14	growth.14	PROPN
bptjm-64	80	24	furthermore	furthermore	ADV
bptjm-64	80	25	,	,	PUNCT
bptjm-64	80	26	increasing	increase	VERB
bptjm-64	80	27	vegf	vegf	NOUN
bptjm-64	80	28	-	-	PUNCT
bptjm-64	80	29	a	a	DET
bptjm-64	80	30	gene	gene	NOUN
bptjm-64	80	31	silencing	silence	VERB
bptjm-64	80	32	e	e	VERB
bptjm-64	80	33	�	�	NOUN
bptjm-64	80	34	ectively	ectively	ADV
bptjm-64	80	35	alleviated	alleviated	ADJ
bptjm-64	80	36	tumor	tumor	NOUN
bptjm-64	80	37	hypoxia	hypoxia	NOUN
bptjm-64	80	38	.	.	PUNCT
bptjm-64	81	1	however	however	ADV
bptjm-64	81	2	,	,	PUNCT
bptjm-64	81	3	it	it	PRON
bptjm-64	81	4	's	be	AUX
bptjm-64	81	5	crucial	crucial	ADJ
bptjm-64	81	6	to	to	PART
bptjm-64	81	7	regulate	regulate	VERB
bptjm-64	81	8	the	the	DET
bptjm-64	81	9	dosage	dosage	NOUN
bptjm-64	81	10	of	of	ADP
bptjm-64	81	11	each	each	DET
bptjm-64	81	12	treatment	treatment	NOUN
bptjm-64	81	13	,	,	PUNCT
bptjm-64	81	14	as	as	SCONJ
bptjm-64	81	15	excessive	excessive	ADJ
bptjm-64	81	16	pshvegf	pshvegf	VERB
bptjm-64	81	17	-	-	PUNCT
bptjm-64	81	18	a	a	DET
bptjm-64	81	19	antibody	antibody	NOUN
bptjm-64	81	20	treatment	treatment	NOUN
bptjm-64	81	21	can	can	AUX
bptjm-64	81	22	exacerbate	exacerbate	VERB
bptjm-64	81	23	tumor	tumor	NOUN
bptjm-64	81	24	hypoxia	hypoxia	NOUN
bptjm-64	81	25	by	by	ADP
bptjm-64	81	26	overly	overly	ADV
bptjm-64	81	27	depleting	deplete	VERB
bptjm-64	81	28	tumor	tumor	NOUN
bptjm-64	81	29	vessels	vessel	NOUN
bptjm-64	81	30	.	.	PUNCT
bptjm-64	82	1	upon	upon	SCONJ
bptjm-64	82	2	treating	treat	VERB
bptjm-64	82	3	tumor	tumor	NOUN
bptjm-64	82	4	-	-	PUNCT
bptjm-64	82	5	infected	infect	VERB
bptjm-64	82	6	mice	mouse	NOUN
bptjm-64	82	7	with	with	ADP
bptjm-64	82	8	the	the	DET
bptjm-64	82	9	dual	dual	ADJ
bptjm-64	82	10	gene	gene	NOUN
bptjm-64	82	11	therapy	therapy	NOUN
bptjm-64	82	12	,	,	PUNCT
bptjm-64	82	13	scientists	scientist	NOUN
bptjm-64	82	14	observed	observe	VERB
bptjm-64	82	15	substantial	substantial	ADJ
bptjm-64	82	16	inhibition	inhibition	NOUN
bptjm-64	82	17	of	of	ADP
bptjm-64	82	18	tumor	tumor	NOUN
bptjm-64	82	19	growth	growth	NOUN
bptjm-64	82	20	and	and	CCONJ
bptjm-64	82	21	prolonged	prolong	VERB
bptjm-64	82	22	overall	overall	ADJ
bptjm-64	82	23	survival	survival	NOUN
bptjm-64	82	24	rates	rate	NOUN
bptjm-64	82	25	compared	compare	VERB
bptjm-64	82	26	to	to	ADP
bptjm-64	82	27	mice	mouse	NOUN
bptjm-64	82	28	treated	treat	VERB
bptjm-64	82	29	with	with	ADP
bptjm-64	82	30	monotherapy.14	monotherapy.14	NOUN
bptjm-64	82	31	this	this	DET
bptjm-64	82	32	dual	dual	ADJ
bptjm-64	82	33	gene	gene	NOUN
bptjm-64	82	34	therapy	therapy	NOUN
bptjm-64	82	35	not	not	PART
bptjm-64	82	36	only	only	ADV
bptjm-64	82	37	countered	counter	VERB
bptjm-64	82	38	immune	immune	ADJ
bptjm-64	82	39	checkpoint	checkpoint	NOUN
bptjm-64	82	40	blockade	blockade	NOUN
bptjm-64	82	41	-	-	PUNCT
bptjm-64	82	42	induced	induce	VERB
bptjm-64	82	43	adaptive	adaptive	ADJ
bptjm-64	82	44	resistance	resistance	NOUN
bptjm-64	82	45	but	but	CCONJ
bptjm-64	82	46	also	also	ADV
bptjm-64	82	47	reversed	reverse	VERB
bptjm-64	82	48	the	the	DET
bptjm-64	82	49	immunosuppressive	immunosuppressive	ADJ
bptjm-64	82	50	tumor	tumor	NOUN
bptjm-64	82	51	microenvironment	microenvironment	NOUN
bptjm-64	82	52	simultaneously	simultaneously	ADV
bptjm-64	82	53	.	.	PUNCT
bptjm-64	83	1	this	this	DET
bptjm-64	83	2	dual	dual	ADJ
bptjm-64	83	3	gene	gene	NOUN
bptjm-64	83	4	delivery	delivery	NOUN
bptjm-64	83	5	system	system	NOUN
bptjm-64	83	6	represents	represent	VERB
bptjm-64	83	7	a	a	DET
bptjm-64	83	8	promising	promising	ADJ
bptjm-64	83	9	avenue	avenue	NOUN
bptjm-64	83	10	for	for	ADP
bptjm-64	83	11	immunotherapy	immunotherapy	NOUN
bptjm-64	83	12	across	across	ADP
bptjm-64	83	13	various	various	ADJ
bptjm-64	83	14	tumor	tumor	NOUN
bptjm-64	83	15	types	type	NOUN
bptjm-64	83	16	,	,	PUNCT
bptjm-64	83	17	though	though	SCONJ
bptjm-64	83	18	further	further	ADJ
bptjm-64	83	19	research	research	NOUN
bptjm-64	83	20	is	be	AUX
bptjm-64	83	21	warranted	warrant	VERB
bptjm-64	83	22	4.1	4.1	NUM
bptjm-64	83	23	lactic	lactic	ADJ
bptjm-64	83	24	acid	acid	NOUN
bptjm-64	83	25	in	in	ADP
bptjm-64	83	26	the	the	DET
bptjm-64	83	27	tumor	tumor	NOUN
bptjm-64	83	28	microenvironment	microenvironment	NOUN
bptjm-64	83	29	one	one	NUM
bptjm-64	83	30	of	of	ADP
bptjm-64	83	31	the	the	DET
bptjm-64	83	32	key	key	ADJ
bptjm-64	83	33	areas	area	NOUN
bptjm-64	83	34	of	of	ADP
bptjm-64	83	35	exploration	exploration	NOUN
bptjm-64	83	36	for	for	ADP
bptjm-64	83	37	scientists	scientist	NOUN
bptjm-64	83	38	has	have	AUX
bptjm-64	83	39	been	be	AUX
bptjm-64	83	40	the	the	DET
bptjm-64	83	41	manipulation	manipulation	NOUN
bptjm-64	83	42	of	of	ADP
bptjm-64	83	43	lactic	lactic	ADJ
bptjm-64	83	44	acid	acid	NOUN
bptjm-64	83	45	within	within	ADP
bptjm-64	83	46	the	the	DET
bptjm-64	83	47	tumor	tumor	NOUN
bptjm-64	83	48	microenvironment	microenvironment	NOUN
bptjm-64	83	49	(	(	PUNCT
bptjm-64	83	50	tme	tme	NOUN
bptjm-64	83	51	)	)	PUNCT
bptjm-64	83	52	.	.	PUNCT
bptjm-64	84	1	lactic	lactic	ADJ
bptjm-64	84	2	acid	acid	NOUN
bptjm-64	84	3	,	,	PUNCT
bptjm-64	84	4	a	a	DET
bptjm-64	84	5	byproduct	byproduct	NOUN
bptjm-64	84	6	of	of	ADP
bptjm-64	84	7	altered	altered	ADJ
bptjm-64	84	8	metabolism	metabolism	NOUN
bptjm-64	84	9	,	,	PUNCT
bptjm-64	84	10	plays	play	VERB
bptjm-64	84	11	a	a	DET
bptjm-64	84	12	signi	signi	ADJ
bptjm-64	84	13	�	�	NOUN
bptjm-64	84	14	cant	cant	NOUN
bptjm-64	84	15	role	role	NOUN
bptjm-64	84	16	in	in	ADP
bptjm-64	84	17	shaping	shape	VERB
bptjm-64	84	18	the	the	DET
bptjm-64	84	19	tme	tme	NOUN
bptjm-64	84	20	.	.	PUNCT
bptjm-64	85	1	its	its	PRON
bptjm-64	85	2	acidic	acidic	ADJ
bptjm-64	85	3	nature	nature	NOUN
bptjm-64	85	4	fosters	foster	VERB
bptjm-64	85	5	various	various	ADJ
bptjm-64	85	6	processes	process	NOUN
bptjm-64	85	7	including	include	VERB
bptjm-64	85	8	angiogenesis	angiogenesis	NOUN
bptjm-64	85	9	,	,	PUNCT
bptjm-64	85	10	metastasis	metastasis	NOUN
bptjm-64	85	11	,	,	PUNCT
bptjm-64	85	12	and	and	CCONJ
bptjm-64	85	13	drug	drug	NOUN
bptjm-64	85	14	resistance	resistance	NOUN
bptjm-64	85	15	.	.	PUNCT
bptjm-64	86	1	a	a	DET
bptjm-64	86	2	2020	2020	NUM
bptjm-64	86	3	study	study	NOUN
bptjm-64	86	4	highlighted	highlight	VERB
bptjm-64	86	5	that	that	SCONJ
bptjm-64	86	6	heightened	heighten	VERB
bptjm-64	86	7	lactic	lactic	ADJ
bptjm-64	86	8	acid	acid	NOUN
bptjm-64	86	9	production	production	NOUN
bptjm-64	86	10	can	can	AUX
bptjm-64	86	11	detrimentally	detrimentally	ADV
bptjm-64	86	12	a	a	DET
bptjm-64	86	13	�	�	NOUN
bptjm-64	86	14	ect	ect	ADJ
bptjm-64	86	15	anticancer	anticancer	NOUN
bptjm-64	86	16	immunity	immunity	NOUN
bptjm-64	86	17	by	by	ADP
bptjm-64	86	18	suppressing	suppress	VERB
bptjm-64	86	19	immune	immune	ADJ
bptjm-64	86	20	responses	response	NOUN
bptjm-64	86	21	due	due	ADP
bptjm-64	86	22	to	to	ADP
bptjm-64	86	23	the	the	DET
bptjm-64	86	24	low	low	ADJ
bptjm-64	86	25	ph	ph	ADJ
bptjm-64	86	26	environment	environment	NOUN
bptjm-64	86	27	it	it	PRON
bptjm-64	86	28	creates.7	creates.7	ADJ
bptjm-64	86	29	lactic	lactic	ADJ
bptjm-64	86	30	acid	acid	PROPN
bptjm-64	86	31	impedes	impede	VERB
bptjm-64	86	32	the	the	DET
bptjm-64	86	33	di	di	PROPN
bptjm-64	86	34	�	�	PROPN
bptjm-64	86	35	erentiation	erentiation	NOUN
bptjm-64	86	36	of	of	ADP
bptjm-64	86	37	monocytes	monocyte	NOUN
bptjm-64	86	38	into	into	ADP
bptjm-64	86	39	dendritic	dendritic	ADJ
bptjm-64	86	40	cells	cell	NOUN
bptjm-64	86	41	,	,	PUNCT
bptjm-64	86	42	leading	lead	VERB
bptjm-64	86	43	to	to	ADP
bptjm-64	86	44	a	a	DET
bptjm-64	86	45	reduction	reduction	NOUN
bptjm-64	86	46	in	in	ADP
bptjm-64	86	47	antigen	antigen	NOUN
bptjm-64	86	48	-	-	PUNCT
bptjm-64	86	49	presenting	present	VERB
bptjm-64	86	50	functions	function	NOUN
bptjm-64	86	51	.	.	PUNCT
bptjm-64	87	1	additionally	additionally	ADV
bptjm-64	87	2	,	,	PUNCT
bptjm-64	87	3	it	it	PRON
bptjm-64	87	4	hampers	hamper	VERB
bptjm-64	87	5	the	the	DET
bptjm-64	87	6	anti	anti	ADJ
bptjm-64	87	7	-	-	ADJ
bptjm-64	87	8	tumoral	tumoral	ADJ
bptjm-64	87	9	activities	activity	NOUN
bptjm-64	87	10	of	of	ADP
bptjm-64	87	11	immune	immune	ADJ
bptjm-64	87	12	cells	cell	NOUN
bptjm-64	87	13	like	like	ADP
bptjm-64	87	14	natural	natural	ADJ
bptjm-64	87	15	killer	killer	NOUN
bptjm-64	87	16	cells	cell	NOUN
bptjm-64	87	17	and	and	CCONJ
bptjm-64	87	18	cytotoxic	cytotoxic	ADJ
bptjm-64	87	19	t	t	NOUN
bptjm-64	87	20	cells.7	cells.7	NOUN
bptjm-64	87	21	consequently	consequently	ADV
bptjm-64	87	22	,	,	PUNCT
bptjm-64	87	23	the	the	DET
bptjm-64	87	24	targeting	targeting	NOUN
bptjm-64	87	25	of	of	ADP
bptjm-64	87	26	lactate	lactate	NOUN
bptjm-64	87	27	and	and	CCONJ
bptjm-64	87	28	lactic	lactic	ADJ
bptjm-64	87	29	acid	acid	NOUN
bptjm-64	87	30	has	have	AUX
bptjm-64	87	31	emerged	emerge	VERB
bptjm-64	87	32	as	as	ADP
bptjm-64	87	33	a	a	DET
bptjm-64	87	34	compelling	compelling	ADJ
bptjm-64	87	35	area	area	NOUN
bptjm-64	87	36	of	of	ADP
bptjm-64	87	37	focus	focus	NOUN
bptjm-64	87	38	within	within	ADP
bptjm-64	87	39	contemporary	contemporary	ADJ
bptjm-64	87	40	immunotherapy	immunotherapy	NOUN
bptjm-64	87	41	research	research	NOUN
bptjm-64	87	42	.	.	PUNCT
bptjm-64	88	1	scientists	scientist	NOUN
bptjm-64	88	2	have	have	AUX
bptjm-64	88	3	been	be	AUX
bptjm-64	88	4	investigating	investigate	VERB
bptjm-64	88	5	the	the	DET
bptjm-64	88	6	neutralization	neutralization	NOUN
bptjm-64	88	7	of	of	ADP
bptjm-64	88	8	lactic	lactic	ADJ
bptjm-64	88	9	acid	acid	NOUN
bptjm-64	88	10	as	as	ADP
bptjm-64	88	11	a	a	DET
bptjm-64	88	12	potential	potential	ADJ
bptjm-64	88	13	method	method	NOUN
bptjm-64	88	14	.	.	PUNCT
bptjm-64	89	1	by	by	ADP
bptjm-64	89	2	bu	bu	PROPN
bptjm-64	89	3	�	�	PROPN
bptjm-64	89	4	ering	ere	VERB
bptjm-64	89	5	the	the	DET
bptjm-64	89	6	tumor	tumor	NOUN
bptjm-64	89	7	microenvironment	microenvironment	NOUN
bptjm-64	89	8	using	use	VERB
bptjm-64	89	9	oral	oral	ADJ
bptjm-64	89	10	bicarbonate	bicarbonate	NOUN
bptjm-64	89	11	and	and	CCONJ
bptjm-64	89	12	coupling	couple	VERB
bptjm-64	89	13	it	it	PRON
bptjm-64	89	14	with	with	ADP
bptjm-64	89	15	anti	anti	ADJ
bptjm-64	89	16	-	-	ADJ
bptjm-64	89	17	pd-1	pd-1	ADJ
bptjm-64	89	18	immunotherapy	immunotherapy	NOUN
bptjm-64	89	19	and	and	CCONJ
bptjm-64	89	20	adoptive	adoptive	PROPN
bptjm-64	89	21	t	t	PROPN
bptjm-64	89	22	-	-	PUNCT
bptjm-64	89	23	cell	cell	NOUN
bptjm-64	89	24	transfer	transfer	NOUN
bptjm-64	89	25	,	,	PUNCT
bptjm-64	89	26	there	there	PRON
bptjm-64	89	27	's	be	VERB
bptjm-64	89	28	potential	potential	NOUN
bptjm-64	89	29	for	for	ADP
bptjm-64	89	30	enhancing	enhance	VERB
bptjm-64	89	31	survival	survival	NOUN
bptjm-64	89	32	rates.5	rates.5	PROPN
bptjm-64	89	33	furthermore	furthermore	ADV
bptjm-64	89	34	,	,	PUNCT
bptjm-64	89	35	research	research	NOUN
bptjm-64	89	36	has	have	AUX
bptjm-64	89	37	shown	show	VERB
bptjm-64	89	38	that	that	SCONJ
bptjm-64	89	39	v	v	NOUN
bptjm-64	89	40	-	-	NOUN
bptjm-64	89	41	domain	domain	VERB
bptjm-64	89	42	ig	ig	PROPN
bptjm-64	89	43	suppressor	suppressor	NOUN
bptjm-64	89	44	of	of	ADP
bptjm-64	89	45	t	t	PROPN
bptjm-64	89	46	cell	cell	NOUN
bptjm-64	89	47	activation	activation	NOUN
bptjm-64	89	48	(	(	PUNCT
bptjm-64	89	49	vista	vista	NOUN
bptjm-64	89	50	)	)	PUNCT
bptjm-64	89	51	can	can	AUX
bptjm-64	89	52	inhibit	inhibit	VERB
bptjm-64	89	53	t	t	NOUN
bptjm-64	89	54	cells	cell	NOUN
bptjm-64	89	55	in	in	ADP
bptjm-64	89	56	an	an	DET
bptjm-64	89	57	acidic	acidic	ADJ
bptjm-64	89	58	ph	ph	ADJ
bptjm-64	89	59	environment	environment	NOUN
bptjm-64	89	60	.	.	PUNCT
bptjm-64	90	1	consequently	consequently	ADV
bptjm-64	90	2	,	,	PUNCT
bptjm-64	90	3	berkeley	berkeley	PROPN
bptjm-64	90	4	pharma	pharma	PROPN
bptjm-64	90	5	tech	tech	NOUN
bptjm-64	90	6	journal	journal	NOUN
bptjm-64	90	7	of	of	ADP
bptjm-64	90	8	medicine	medicine	NOUN
bptjm-64	90	9	|	|	ADV
bptjm-64	90	10	125	125	NUM
bptjm-64	90	11	blocking	block	VERB
bptjm-64	90	12	vista	vista	NOUN
bptjm-64	90	13	in	in	ADP
bptjm-64	90	14	conjunction	conjunction	NOUN
bptjm-64	90	15	with	with	ADP
bptjm-64	90	16	pd-1	pd-1	ADJ
bptjm-64	90	17	blockade	blockade	NOUN
bptjm-64	90	18	,	,	PUNCT
bptjm-64	90	19	and	and	CCONJ
bptjm-64	90	20	the	the	DET
bptjm-64	90	21	development	development	NOUN
bptjm-64	90	22	of	of	ADP
bptjm-64	90	23	ph	ph	ADJ
bptjm-64	90	24	-	-	PUNCT
bptjm-64	90	25	speci	speci	ADJ
bptjm-64	90	26	�	�	PROPN
bptjm-64	90	27	c	c	PROPN
bptjm-64	90	28	antibodies	antibodie	VERB
bptjm-64	90	29	against	against	ADP
bptjm-64	90	30	vista	vista	NOUN
bptjm-64	90	31	,	,	PUNCT
bptjm-64	90	32	have	have	AUX
bptjm-64	90	33	demonstrated	demonstrate	VERB
bptjm-64	90	34	e	e	PROPN
bptjm-64	90	35	�	�	NOUN
bptjm-64	90	36	cacy	cacy	NOUN
bptjm-64	90	37	in	in	ADP
bptjm-64	90	38	tumor	tumor	NOUN
bptjm-64	90	39	rejection.5	rejection.5	ADP
bptjm-64	90	40	another	another	DET
bptjm-64	90	41	signi	signi	PROPN
bptjm-64	90	42	�	�	NOUN
bptjm-64	90	43	cant	cant	NOUN
bptjm-64	90	44	focus	focus	NOUN
bptjm-64	90	45	lies	lie	NOUN
bptjm-64	90	46	in	in	ADP
bptjm-64	90	47	targeting	target	VERB
bptjm-64	90	48	the	the	DET
bptjm-64	90	49	lactate	lactate	NOUN
bptjm-64	90	50	-	-	PUNCT
bptjm-64	90	51	producing	produce	VERB
bptjm-64	90	52	enzyme	enzyme	NOUN
bptjm-64	90	53	ldh	ldh	NOUN
bptjm-64	90	54	,	,	PUNCT
bptjm-64	90	55	which	which	PRON
bptjm-64	90	56	shows	show	VERB
bptjm-64	90	57	promising	promise	VERB
bptjm-64	90	58	anti	anti	ADJ
bptjm-64	90	59	-	-	ADJ
bptjm-64	90	60	cancer	cancer	ADJ
bptjm-64	90	61	e	e	NOUN
bptjm-64	90	62	�	�	NOUN
bptjm-64	90	63	ects	ect	NOUN
bptjm-64	90	64	.	.	PUNCT
bptjm-64	91	1	however	however	ADV
bptjm-64	91	2	,	,	PUNCT
bptjm-64	91	3	its	its	PRON
bptjm-64	91	4	impact	impact	NOUN
bptjm-64	91	5	on	on	ADP
bptjm-64	91	6	immune	immune	ADJ
bptjm-64	91	7	cells	cell	NOUN
bptjm-64	91	8	remains	remain	VERB
bptjm-64	91	9	largely	largely	ADV
bptjm-64	91	10	unexplored	unexplored	ADJ
bptjm-64	91	11	,	,	PUNCT
bptjm-64	91	12	as	as	SCONJ
bptjm-64	91	13	ldh	ldh	NOUN
bptjm-64	91	14	inhibition	inhibition	NOUN
bptjm-64	91	15	can	can	AUX
bptjm-64	91	16	decrease	decrease	VERB
bptjm-64	91	17	t	t	PROPN
bptjm-64	91	18	cell	cell	NOUN
bptjm-64	91	19	levels5	levels5	PROPN
bptjm-64	91	20	.	.	PUNCT
bptjm-64	92	1	an	an	DET
bptjm-64	92	2	alternative	alternative	ADJ
bptjm-64	92	3	approach	approach	NOUN
bptjm-64	92	4	involves	involve	VERB
bptjm-64	92	5	inhibiting	inhibit	VERB
bptjm-64	92	6	lactate	lactate	NOUN
bptjm-64	92	7	transporters	transporter	NOUN
bptjm-64	92	8	.	.	PUNCT
bptjm-64	93	1	notably	notably	ADV
bptjm-64	93	2	,	,	PUNCT
bptjm-64	93	3	researchers	researcher	NOUN
bptjm-64	93	4	identi	identi	VERB
bptjm-64	93	5	�	�	PROPN
bptjm-64	93	6	ed	ed	PROPN
bptjm-64	93	7	slc4a4	slc4a4	NOUN
bptjm-64	93	8	as	as	ADP
bptjm-64	93	9	the	the	DET
bptjm-64	93	10	predominant	predominant	ADJ
bptjm-64	93	11	bicarbonate	bicarbonate	NOUN
bptjm-64	93	12	transporter	transporter	NOUN
bptjm-64	93	13	in	in	ADP
bptjm-64	93	14	pancreatic	pancreatic	ADJ
bptjm-64	93	15	ductal	ductal	ADJ
bptjm-64	93	16	adenocarcinoma	adenocarcinoma	NOUN
bptjm-64	93	17	(	(	PUNCT
bptjm-64	93	18	pdac	pdac	NOUN
bptjm-64	93	19	)	)	PUNCT
bptjm-64	93	20	.	.	PUNCT
bptjm-64	94	1	inhibiting	inhibit	VERB
bptjm-64	94	2	slc4a4	slc4a4	NOUN
bptjm-64	94	3	in	in	ADP
bptjm-64	94	4	pdac	pdac	NOUN
bptjm-64	94	5	cells	cell	NOUN
bptjm-64	94	6	reduces	reduce	VERB
bptjm-64	94	7	tme	tme	X
bptjm-64	94	8	acidi	acidi	PROPN
bptjm-64	94	9	�	�	PROPN
bptjm-64	94	10	cation	cation	NOUN
bptjm-64	94	11	by	by	ADP
bptjm-64	94	12	accumulating	accumulate	VERB
bptjm-64	94	13	bicarbonate	bicarbonate	NOUN
bptjm-64	94	14	in	in	ADP
bptjm-64	94	15	the	the	DET
bptjm-64	94	16	extracellular	extracellular	ADJ
bptjm-64	94	17	space	space	NOUN
bptjm-64	94	18	and	and	CCONJ
bptjm-64	94	19	lowering	lower	VERB
bptjm-64	94	20	lactate	lactate	NOUN
bptjm-64	94	21	production	production	NOUN
bptjm-64	94	22	.	.	PUNCT
bptjm-64	95	1	combining	combine	VERB
bptjm-64	95	2	slc4a4	slc4a4	NOUN
bptjm-64	95	3	targeting	target	VERB
bptjm-64	95	4	with	with	ADP
bptjm-64	95	5	immune	immune	ADJ
bptjm-64	95	6	checkpoint	checkpoint	NOUN
bptjm-64	95	7	blockades	blockade	NOUN
bptjm-64	95	8	has	have	AUX
bptjm-64	95	9	been	be	AUX
bptjm-64	95	10	found	find	VERB
bptjm-64	95	11	to	to	PART
bptjm-64	95	12	overcome	overcome	VERB
bptjm-64	95	13	immunotherapy	immunotherapy	NOUN
bptjm-64	95	14	resistance.6	resistance.6	NOUN
bptjm-64	95	15	targeting	target	VERB
bptjm-64	95	16	lactic	lactic	ADJ
bptjm-64	95	17	acid	acid	NOUN
bptjm-64	95	18	holds	hold	VERB
bptjm-64	95	19	signi	signi	PROPN
bptjm-64	95	20	�	�	NOUN
bptjm-64	95	21	cant	cant	VERB
bptjm-64	95	22	promise	promise	NOUN
bptjm-64	95	23	for	for	ADP
bptjm-64	95	24	advancing	advance	VERB
bptjm-64	95	25	immunotherapy	immunotherapy	NOUN
bptjm-64	95	26	in	in	ADP
bptjm-64	95	27	the	the	DET
bptjm-64	95	28	tumor	tumor	NOUN
bptjm-64	95	29	microenvironment	microenvironment	NOUN
bptjm-64	95	30	,	,	PUNCT
bptjm-64	95	31	as	as	SCONJ
bptjm-64	95	32	it	it	PRON
bptjm-64	95	33	plays	play	VERB
bptjm-64	95	34	a	a	DET
bptjm-64	95	35	pivotal	pivotal	ADJ
bptjm-64	95	36	role	role	NOUN
bptjm-64	95	37	in	in	ADP
bptjm-64	95	38	tme	tme	PROPN
bptjm-64	95	39	acidi	acidi	PROPN
bptjm-64	95	40	�	�	PROPN
bptjm-64	95	41	cation	cation	NOUN
bptjm-64	95	42	and	and	CCONJ
bptjm-64	95	43	subsequent	subsequent	ADJ
bptjm-64	95	44	immune	immune	ADJ
bptjm-64	95	45	response	response	NOUN
bptjm-64	95	46	suppression	suppression	NOUN
bptjm-64	95	47	.	.	PUNCT
bptjm-64	96	1	4.2	4.2	NUM
bptjm-64	96	2	targeting	target	VERB
bptjm-64	96	3	metabolism	metabolism	NOUN
bptjm-64	96	4	in	in	ADP
bptjm-64	96	5	the	the	DET
bptjm-64	96	6	tumor	tumor	NOUN
bptjm-64	96	7	microenvironment	microenvironment	NOUN
bptjm-64	96	8	focusing	focus	VERB
bptjm-64	96	9	on	on	ADP
bptjm-64	96	10	metabolism	metabolism	NOUN
bptjm-64	96	11	to	to	PART
bptjm-64	96	12	enhance	enhance	VERB
bptjm-64	96	13	the	the	DET
bptjm-64	96	14	tumor	tumor	NOUN
bptjm-64	96	15	microenvironment	microenvironment	NOUN
bptjm-64	96	16	for	for	ADP
bptjm-64	96	17	cancer	cancer	NOUN
bptjm-64	96	18	immunotherapy	immunotherapy	NOUN
bptjm-64	96	19	holds	hold	VERB
bptjm-64	96	20	signi	signi	PROPN
bptjm-64	96	21	�	�	NOUN
bptjm-64	96	22	cant	cant	VERB
bptjm-64	96	23	promise	promise	NOUN
bptjm-64	96	24	.	.	PUNCT
bptjm-64	97	1	cancer	cancer	NOUN
bptjm-64	97	2	cells	cell	NOUN
bptjm-64	97	3	exhibit	exhibit	VERB
bptjm-64	97	4	heightened	heighten	VERB
bptjm-64	97	5	metabolic	metabolic	NOUN
bptjm-64	97	6	activity	activity	NOUN
bptjm-64	97	7	,	,	PUNCT
bptjm-64	97	8	fueling	fuel	VERB
bptjm-64	97	9	their	their	PRON
bptjm-64	97	10	rapid	rapid	ADJ
bptjm-64	97	11	proliferation	proliferation	NOUN
bptjm-64	97	12	.	.	PUNCT
bptjm-64	98	1	by	by	ADP
bptjm-64	98	2	zeroing	zero	VERB
bptjm-64	98	3	in	in	ADP
bptjm-64	98	4	on	on	ADP
bptjm-64	98	5	metabolism	metabolism	NOUN
bptjm-64	98	6	,	,	PUNCT
bptjm-64	98	7	scientists	scientist	NOUN
bptjm-64	98	8	can	can	AUX
bptjm-64	98	9	slow	slow	VERB
bptjm-64	98	10	down	down	ADP
bptjm-64	98	11	cancer	cancer	NOUN
bptjm-64	98	12	cell	cell	NOUN
bptjm-64	98	13	spread	spread	VERB
bptjm-64	98	14	and	and	CCONJ
bptjm-64	98	15	impede	impede	VERB
bptjm-64	98	16	their	their	PRON
bptjm-64	98	17	function	function	NOUN
bptjm-64	98	18	.	.	PUNCT
bptjm-64	99	1	the	the	DET
bptjm-64	99	2	realm	realm	NOUN
bptjm-64	99	3	of	of	ADP
bptjm-64	99	4	immune	immune	ADJ
bptjm-64	99	5	metabolism	metabolism	NOUN
bptjm-64	99	6	o	o	NOUN
bptjm-64	99	7	�	�	NOUN
bptjm-64	99	8	ers	er	VERB
bptjm-64	99	9	potential	potential	ADJ
bptjm-64	99	10	metabolic	metabolic	NOUN
bptjm-64	99	11	targets	target	NOUN
bptjm-64	99	12	to	to	PART
bptjm-64	99	13	bolster	bolster	VERB
bptjm-64	99	14	anti	anti	ADJ
bptjm-64	99	15	-	-	ADJ
bptjm-64	99	16	cancer	cancer	ADJ
bptjm-64	99	17	immunity	immunity	NOUN
bptjm-64	99	18	.	.	PUNCT
bptjm-64	100	1	the	the	DET
bptjm-64	100	2	dynamic	dynamic	ADJ
bptjm-64	100	3	metabolism	metabolism	NOUN
bptjm-64	100	4	of	of	ADP
bptjm-64	100	5	immune	immune	ADJ
bptjm-64	100	6	cells	cell	NOUN
bptjm-64	100	7	signi	signi	VERB
bptjm-64	100	8	�	�	NOUN
bptjm-64	100	9	cantly	cantly	ADV
bptjm-64	100	10	in	in	ADP
bptjm-64	100	11	�	�	PROPN
bptjm-64	100	12	uences	uence	NOUN
bptjm-64	100	13	their	their	PRON
bptjm-64	100	14	functions	function	NOUN
bptjm-64	100	15	as	as	ADP
bptjm-64	100	16	well.25	well.25	NOUN
bptjm-64	100	17	a	a	DET
bptjm-64	100	18	primary	primary	ADJ
bptjm-64	100	19	approach	approach	NOUN
bptjm-64	100	20	involves	involve	VERB
bptjm-64	100	21	targeting	target	VERB
bptjm-64	100	22	amino	amino	NOUN
bptjm-64	100	23	acid	acid	NOUN
bptjm-64	100	24	metabolism	metabolism	NOUN
bptjm-64	100	25	,	,	PUNCT
bptjm-64	100	26	where	where	SCONJ
bptjm-64	100	27	speci	speci	PROPN
bptjm-64	100	28	�	�	PROPN
bptjm-64	100	29	c	c	NOUN
bptjm-64	100	30	amino	amino	ADJ
bptjm-64	100	31	acids	acid	NOUN
bptjm-64	100	32	such	such	ADJ
bptjm-64	100	33	as	as	ADP
bptjm-64	100	34	glutamine	glutamine	NOUN
bptjm-64	100	35	,	,	PUNCT
bptjm-64	100	36	tryptophan	tryptophan	NOUN
bptjm-64	100	37	,	,	PUNCT
bptjm-64	100	38	and	and	CCONJ
bptjm-64	100	39	arginine	arginine	NOUN
bptjm-64	100	40	have	have	AUX
bptjm-64	100	41	emerged	emerge	VERB
bptjm-64	100	42	as	as	ADP
bptjm-64	100	43	key	key	ADJ
bptjm-64	100	44	targets	target	NOUN
bptjm-64	100	45	for	for	ADP
bptjm-64	100	46	inhibiting	inhibit	VERB
bptjm-64	100	47	tumor	tumor	NOUN
bptjm-64	100	48	progression	progression	NOUN
bptjm-64	100	49	and	and	CCONJ
bptjm-64	100	50	enhancing	enhance	VERB
bptjm-64	100	51	immunity	immunity	NOUN
bptjm-64	100	52	.	.	PUNCT
bptjm-64	101	1	glutamine	glutamine	NOUN
bptjm-64	101	2	,	,	PUNCT
bptjm-64	101	3	in	in	ADP
bptjm-64	101	4	particular	particular	ADJ
bptjm-64	101	5	,	,	PUNCT
bptjm-64	101	6	plays	play	VERB
bptjm-64	101	7	a	a	DET
bptjm-64	101	8	vital	vital	ADJ
bptjm-64	101	9	role	role	NOUN
bptjm-64	101	10	as	as	ADP
bptjm-64	101	11	a	a	DET
bptjm-64	101	12	nutrient	nutrient	NOUN
bptjm-64	101	13	for	for	ADP
bptjm-64	101	14	cancer	cancer	NOUN
bptjm-64	101	15	cells	cell	NOUN
bptjm-64	101	16	.	.	PUNCT
bptjm-64	102	1	enzymes	enzyme	NOUN
bptjm-64	102	2	like	like	ADP
bptjm-64	102	3	glutaminase	glutaminase	NOUN
bptjm-64	102	4	(	(	PUNCT
bptjm-64	102	5	gls	gls	PROPN
bptjm-64	102	6	)	)	PUNCT
bptjm-64	102	7	facilitate	facilitate	VERB
bptjm-64	102	8	the	the	DET
bptjm-64	102	9	conversion	conversion	NOUN
bptjm-64	102	10	of	of	ADP
bptjm-64	102	11	glutamine	glutamine	NOUN
bptjm-64	102	12	to	to	PART
bptjm-64	102	13	glutamate	glutamate	VERB
bptjm-64	102	14	,	,	PUNCT
bptjm-64	102	15	making	make	VERB
bptjm-64	102	16	gls	gl	VERB
bptjm-64	102	17	a	a	DET
bptjm-64	102	18	prime	prime	ADJ
bptjm-64	102	19	target	target	NOUN
bptjm-64	102	20	to	to	PART
bptjm-64	102	21	curb	curb	VERB
bptjm-64	102	22	cancer	cancer	NOUN
bptjm-64	102	23	cell	cell	NOUN
bptjm-64	102	24	metabolism	metabolism	NOUN
bptjm-64	102	25	and	and	CCONJ
bptjm-64	102	26	glucose	glucose	NOUN
bptjm-64	102	27	utilization	utilization	NOUN
bptjm-64	102	28	.	.	PUNCT
bptjm-64	103	1	however	however	ADV
bptjm-64	103	2	,	,	PUNCT
bptjm-64	103	3	targeting	target	VERB
bptjm-64	103	4	gls	gls	NOUN
bptjm-64	103	5	poses	pose	NOUN
bptjm-64	103	6	challenges	challenge	NOUN
bptjm-64	103	7	as	as	SCONJ
bptjm-64	103	8	cancer	cancer	NOUN
bptjm-64	103	9	cells	cell	NOUN
bptjm-64	103	10	employ	employ	VERB
bptjm-64	103	11	alternative	alternative	ADJ
bptjm-64	103	12	methods	method	NOUN
bptjm-64	103	13	to	to	PART
bptjm-64	103	14	boost	boost	VERB
bptjm-64	103	15	glucose	glucose	NOUN
bptjm-64	103	16	metabolism	metabolism	NOUN
bptjm-64	103	17	.	.	PUNCT
bptjm-64	104	1	additionally	additionally	ADV
bptjm-64	104	2	,	,	PUNCT
bptjm-64	104	3	directing	direct	VERB
bptjm-64	104	4	gls	gls	NOUN
bptjm-64	104	5	inhibition	inhibition	NOUN
bptjm-64	104	6	towards	towards	ADP
bptjm-64	104	7	immune	immune	ADJ
bptjm-64	104	8	cells	cell	NOUN
bptjm-64	104	9	,	,	PUNCT
bptjm-64	104	10	particularly	particularly	ADV
bptjm-64	104	11	t	t	NOUN
bptjm-64	104	12	cells	cell	NOUN
bptjm-64	104	13	,	,	PUNCT
bptjm-64	104	14	a	a	DET
bptjm-64	104	15	�	�	NOUN
bptjm-64	104	16	ects	ect	VERB
bptjm-64	104	17	berkeley	berkeley	PROPN
bptjm-64	104	18	pharma	pharma	PROPN
bptjm-64	104	19	tech	tech	NOUN
bptjm-64	104	20	journal	journal	NOUN
bptjm-64	104	21	of	of	ADP
bptjm-64	104	22	medicine	medicine	NOUN
bptjm-64	104	23	|	|	ADV
bptjm-64	104	24	126	126	NUM
bptjm-64	104	25	their	their	PRON
bptjm-64	104	26	di	di	NOUN
bptjm-64	104	27	�	�	PROPN
bptjm-64	104	28	erentiation	erentiation	NOUN
bptjm-64	104	29	,	,	PUNCT
bptjm-64	104	30	survival	survival	NOUN
bptjm-64	104	31	,	,	PUNCT
bptjm-64	104	32	proliferation	proliferation	NOUN
bptjm-64	104	33	,	,	PUNCT
bptjm-64	104	34	and	and	CCONJ
bptjm-64	104	35	e	e	NOUN
bptjm-64	104	36	�	�	PROPN
bptjm-64	104	37	ector	ector	NOUN
bptjm-64	104	38	functions.5	functions.5	NOUN
bptjm-64	104	39	this	this	PRON
bptjm-64	104	40	presents	present	VERB
bptjm-64	104	41	a	a	DET
bptjm-64	104	42	signi	signi	ADJ
bptjm-64	104	43	�	�	NOUN
bptjm-64	104	44	cant	cant	NOUN
bptjm-64	104	45	hurdle	hurdle	NOUN
bptjm-64	104	46	,	,	PUNCT
bptjm-64	104	47	as	as	SCONJ
bptjm-64	104	48	it	it	PRON
bptjm-64	104	49	necessitates	necessitate	VERB
bptjm-64	104	50	reducing	reduce	VERB
bptjm-64	104	51	glutamate	glutamate	ADJ
bptjm-64	104	52	levels	level	NOUN
bptjm-64	104	53	in	in	ADP
bptjm-64	104	54	cancer	cancer	NOUN
bptjm-64	104	55	cells	cell	NOUN
bptjm-64	104	56	while	while	SCONJ
bptjm-64	104	57	ensuring	ensure	VERB
bptjm-64	104	58	adequate	adequate	ADJ
bptjm-64	104	59	glutamine	glutamine	NOUN
bptjm-64	104	60	for	for	ADP
bptjm-64	104	61	proper	proper	ADJ
bptjm-64	104	62	t	t	NOUN
bptjm-64	104	63	cell	cell	NOUN
bptjm-64	104	64	function	function	NOUN
bptjm-64	104	65	.	.	PUNCT
bptjm-64	105	1	consequently	consequently	ADV
bptjm-64	105	2	,	,	PUNCT
bptjm-64	105	3	a	a	DET
bptjm-64	105	4	strategy	strategy	NOUN
bptjm-64	105	5	has	have	AUX
bptjm-64	105	6	been	be	AUX
bptjm-64	105	7	devised	devise	VERB
bptjm-64	105	8	to	to	PART
bptjm-64	105	9	broadly	broadly	ADV
bptjm-64	105	10	block	block	VERB
bptjm-64	105	11	glutamine	glutamine	NOUN
bptjm-64	105	12	metabolism	metabolism	NOUN
bptjm-64	105	13	alongside	alongside	ADP
bptjm-64	105	14	anti	anti	ADJ
bptjm-64	105	15	-	-	ADJ
bptjm-64	105	16	pd-1	pd-1	ADJ
bptjm-64	105	17	immunotherapy	immunotherapy	NOUN
bptjm-64	105	18	.	.	PUNCT
bptjm-64	106	1	this	this	DET
bptjm-64	106	2	combined	combine	VERB
bptjm-64	106	3	approach	approach	NOUN
bptjm-64	106	4	enhances	enhance	VERB
bptjm-64	106	5	anti	anti	ADJ
bptjm-64	106	6	-	-	ADJ
bptjm-64	106	7	tumor	tumor	ADJ
bptjm-64	106	8	e	e	NOUN
bptjm-64	106	9	�	�	NOUN
bptjm-64	106	10	ects	ect	NOUN
bptjm-64	106	11	by	by	ADP
bptjm-64	106	12	dampening	dampen	VERB
bptjm-64	106	13	tumor	tumor	NOUN
bptjm-64	106	14	metabolism	metabolism	NOUN
bptjm-64	106	15	while	while	SCONJ
bptjm-64	106	16	maintaining	maintain	VERB
bptjm-64	106	17	robust	robust	ADJ
bptjm-64	106	18	glucose	glucose	NOUN
bptjm-64	106	19	metabolism	metabolism	NOUN
bptjm-64	106	20	in	in	ADP
bptjm-64	106	21	t	t	PROPN
bptjm-64	106	22	cells.5	cells.5	PROPN
bptjm-64	106	23	furthermore	furthermore	ADV
bptjm-64	106	24	,	,	PUNCT
bptjm-64	106	25	researchers	researcher	NOUN
bptjm-64	106	26	have	have	AUX
bptjm-64	106	27	shown	show	VERB
bptjm-64	106	28	keen	keen	ADJ
bptjm-64	106	29	interest	interest	NOUN
bptjm-64	106	30	in	in	ADP
bptjm-64	106	31	targeting	target	VERB
bptjm-64	106	32	arginine	arginine	NOUN
bptjm-64	106	33	and	and	CCONJ
bptjm-64	106	34	nitric	nitric	ADJ
bptjm-64	106	35	oxide	oxide	NOUN
bptjm-64	106	36	,	,	PUNCT
bptjm-64	106	37	delving	delve	VERB
bptjm-64	106	38	into	into	ADP
bptjm-64	106	39	amino	amino	NOUN
bptjm-64	106	40	acid	acid	NOUN
bptjm-64	106	41	metabolism	metabolism	NOUN
bptjm-64	106	42	.	.	PUNCT
bptjm-64	107	1	arginine	arginine	PROPN
bptjm-64	107	2	plays	play	VERB
bptjm-64	107	3	a	a	DET
bptjm-64	107	4	pivotal	pivotal	ADJ
bptjm-64	107	5	role	role	NOUN
bptjm-64	107	6	in	in	ADP
bptjm-64	107	7	cancer	cancer	NOUN
bptjm-64	107	8	and	and	CCONJ
bptjm-64	107	9	immune	immune	ADJ
bptjm-64	107	10	cell	cell	NOUN
bptjm-64	107	11	functions	function	NOUN
bptjm-64	107	12	,	,	PUNCT
bptjm-64	107	13	particularly	particularly	ADV
bptjm-64	107	14	in	in	ADP
bptjm-64	107	15	proliferation	proliferation	NOUN
bptjm-64	107	16	,	,	PUNCT
bptjm-64	107	17	survival	survival	NOUN
bptjm-64	107	18	,	,	PUNCT
bptjm-64	107	19	and	and	CCONJ
bptjm-64	107	20	protein	protein	NOUN
bptjm-64	107	21	synthesis	synthesis	NOUN
bptjm-64	107	22	.	.	PUNCT
bptjm-64	108	1	the	the	DET
bptjm-64	108	2	metabolic	metabolic	NOUN
bptjm-64	108	3	pathways	pathway	NOUN
bptjm-64	108	4	of	of	ADP
bptjm-64	108	5	arginine	arginine	NOUN
bptjm-64	108	6	heavily	heavily	ADV
bptjm-64	108	7	rely	rely	VERB
bptjm-64	108	8	on	on	ADP
bptjm-64	108	9	enzymes	enzyme	NOUN
bptjm-64	108	10	like	like	ADP
bptjm-64	108	11	arginase	arginase	NOUN
bptjm-64	108	12	(	(	PUNCT
bptjm-64	108	13	arg	arg	NOUN
bptjm-64	108	14	)	)	PUNCT
bptjm-64	108	15	and	and	CCONJ
bptjm-64	108	16	nitric	nitric	ADJ
bptjm-64	108	17	oxide	oxide	NOUN
bptjm-64	108	18	synthase	synthase	NOUN
bptjm-64	108	19	(	(	PUNCT
bptjm-64	108	20	nos	nos	NOUN
bptjm-64	108	21	)	)	PUNCT
bptjm-64	108	22	.	.	PUNCT
bptjm-64	109	1	however	however	ADV
bptjm-64	109	2	,	,	PUNCT
bptjm-64	109	3	given	give	VERB
bptjm-64	109	4	arginine	arginine	NOUN
bptjm-64	109	5	's	's	PART
bptjm-64	109	6	signi	signi	PROPN
bptjm-64	109	7	�	�	NOUN
bptjm-64	109	8	cance	cance	NOUN
bptjm-64	109	9	to	to	ADP
bptjm-64	109	10	both	both	DET
bptjm-64	109	11	cancer	cancer	NOUN
bptjm-64	109	12	and	and	CCONJ
bptjm-64	109	13	immune	immune	ADJ
bptjm-64	109	14	cells	cell	NOUN
bptjm-64	109	15	,	,	PUNCT
bptjm-64	109	16	its	its	PRON
bptjm-64	109	17	potential	potential	NOUN
bptjm-64	109	18	as	as	ADP
bptjm-64	109	19	a	a	DET
bptjm-64	109	20	therapeutic	therapeutic	ADJ
bptjm-64	109	21	target	target	NOUN
bptjm-64	109	22	presents	present	VERB
bptjm-64	109	23	complexities	complexity	NOUN
bptjm-64	109	24	.	.	PUNCT
bptjm-64	110	1	while	while	SCONJ
bptjm-64	110	2	arginine	arginine	NOUN
bptjm-64	110	3	depletion	depletion	NOUN
bptjm-64	110	4	proves	prove	VERB
bptjm-64	110	5	e	e	NOUN
bptjm-64	110	6	�	�	NOUN
bptjm-64	110	7	ective	ective	ADJ
bptjm-64	110	8	in	in	ADP
bptjm-64	110	9	certain	certain	ADJ
bptjm-64	110	10	scenarios	scenario	NOUN
bptjm-64	110	11	,	,	PUNCT
bptjm-64	110	12	it	it	PRON
bptjm-64	110	13	can	can	AUX
bptjm-64	110	14	hinder	hinder	VERB
bptjm-64	110	15	anti	anti	ADJ
bptjm-64	110	16	-	-	ADJ
bptjm-64	110	17	tumor	tumor	ADJ
bptjm-64	110	18	t	t	NOUN
bptjm-64	110	19	cell	cell	NOUN
bptjm-64	110	20	responses	response	NOUN
bptjm-64	110	21	and	and	CCONJ
bptjm-64	110	22	bolster	bolster	VERB
bptjm-64	110	23	the	the	DET
bptjm-64	110	24	population	population	NOUN
bptjm-64	110	25	of	of	ADP
bptjm-64	110	26	myeloid	myeloid	NOUN
bptjm-64	110	27	-	-	PUNCT
bptjm-64	110	28	derived	derive	VERB
bptjm-64	110	29	suppressor	suppressor	NOUN
bptjm-64	110	30	cells	cell	NOUN
bptjm-64	110	31	(	(	PUNCT
bptjm-64	110	32	mdscs	mdsc	NOUN
bptjm-64	110	33	)	)	PUNCT
bptjm-64	110	34	,	,	PUNCT
bptjm-64	110	35	thus	thus	ADV
bptjm-64	110	36	exacerbating	exacerbate	VERB
bptjm-64	110	37	arginine	arginine	NOUN
bptjm-64	110	38	depletion.5	depletion.5	PROPN
bptjm-64	110	39	yet	yet	ADV
bptjm-64	110	40	,	,	PUNCT
bptjm-64	110	41	inhibiting	inhibit	VERB
bptjm-64	110	42	arg	arg	NOUN
bptjm-64	110	43	o	o	NOUN
bptjm-64	110	44	�	�	NOUN
bptjm-64	110	45	ers	er	NOUN
bptjm-64	110	46	promise	promise	VERB
bptjm-64	110	47	by	by	ADP
bptjm-64	110	48	restoring	restore	VERB
bptjm-64	110	49	arginine	arginine	NOUN
bptjm-64	110	50	levels	level	NOUN
bptjm-64	110	51	,	,	PUNCT
bptjm-64	110	52	leading	lead	VERB
bptjm-64	110	53	to	to	ADP
bptjm-64	110	54	tumor	tumor	NOUN
bptjm-64	110	55	regression	regression	NOUN
bptjm-64	110	56	and	and	CCONJ
bptjm-64	110	57	enhancing	enhance	VERB
bptjm-64	110	58	t	t	PROPN
bptjm-64	110	59	cell	cell	NOUN
bptjm-64	110	60	functionalities.5	functionalities.5	PROPN
bptjm-64	110	61	targeting	target	VERB
bptjm-64	110	62	arginine	arginine	NOUN
bptjm-64	110	63	and	and	CCONJ
bptjm-64	110	64	nitric	nitric	ADJ
bptjm-64	110	65	oxide	oxide	NOUN
bptjm-64	110	66	in	in	ADP
bptjm-64	110	67	myeloid	myeloid	ADJ
bptjm-64	110	68	cells	cell	NOUN
bptjm-64	110	69	could	could	AUX
bptjm-64	110	70	potentially	potentially	ADV
bptjm-64	110	71	enhance	enhance	VERB
bptjm-64	110	72	immunotherapy	immunotherapy	NOUN
bptjm-64	110	73	,	,	PUNCT
bptjm-64	110	74	but	but	CCONJ
bptjm-64	110	75	further	further	ADJ
bptjm-64	110	76	research	research	NOUN
bptjm-64	110	77	is	be	AUX
bptjm-64	110	78	needed	need	VERB
bptjm-64	110	79	to	to	PART
bptjm-64	110	80	understand	understand	VERB
bptjm-64	110	81	its	its	PRON
bptjm-64	110	82	impact	impact	NOUN
bptjm-64	110	83	on	on	ADP
bptjm-64	110	84	other	other	ADJ
bptjm-64	110	85	immune	immune	ADJ
bptjm-64	110	86	cells	cell	NOUN
bptjm-64	110	87	.	.	PUNCT
bptjm-64	111	1	tryptophan	tryptophan	NOUN
bptjm-64	111	2	is	be	AUX
bptjm-64	111	3	another	another	DET
bptjm-64	111	4	signi	signi	PROPN
bptjm-64	111	5	�	�	NOUN
bptjm-64	111	6	cant	cant	VERB
bptjm-64	111	7	amino	amino	NOUN
bptjm-64	111	8	acid	acid	NOUN
bptjm-64	111	9	being	be	AUX
bptjm-64	111	10	investigated	investigate	VERB
bptjm-64	111	11	for	for	ADP
bptjm-64	111	12	immunotherapy	immunotherapy	NOUN
bptjm-64	111	13	due	due	ADP
bptjm-64	111	14	to	to	ADP
bptjm-64	111	15	its	its	PRON
bptjm-64	111	16	role	role	NOUN
bptjm-64	111	17	in	in	ADP
bptjm-64	111	18	cell	cell	NOUN
bptjm-64	111	19	growth	growth	NOUN
bptjm-64	111	20	and	and	CCONJ
bptjm-64	111	21	maintenance	maintenance	NOUN
bptjm-64	111	22	.	.	PUNCT
bptjm-64	112	1	adaptive	adaptive	ADJ
bptjm-64	112	2	immune	immune	ADJ
bptjm-64	112	3	cell	cell	NOUN
bptjm-64	112	4	subsets	subset	NOUN
bptjm-64	112	5	such	such	ADJ
bptjm-64	112	6	as	as	ADP
bptjm-64	112	7	tregs	treg	NOUN
bptjm-64	112	8	,	,	PUNCT
bptjm-64	112	9	tolerogenic	tolerogenic	ADJ
bptjm-64	112	10	dendritic	dendritic	ADJ
bptjm-64	112	11	cells	cell	NOUN
bptjm-64	112	12	(	(	PUNCT
bptjm-64	112	13	dcs	dcs	PROPN
bptjm-64	112	14	)	)	PUNCT
bptjm-64	112	15	,	,	PUNCT
bptjm-64	112	16	and	and	CCONJ
bptjm-64	112	17	myeloid	myeloid	ADJ
bptjm-64	112	18	-	-	PUNCT
bptjm-64	112	19	derived	derive	VERB
bptjm-64	112	20	suppressor	suppressor	NOUN
bptjm-64	112	21	cells	cell	NOUN
bptjm-64	112	22	(	(	PUNCT
bptjm-64	112	23	mdscs	mdsc	NOUN
bptjm-64	112	24	)	)	PUNCT
bptjm-64	112	25	exhibit	exhibit	VERB
bptjm-64	112	26	high	high	ADJ
bptjm-64	112	27	levels	level	NOUN
bptjm-64	112	28	of	of	ADP
bptjm-64	112	29	indoleamine	indoleamine	NOUN
bptjm-64	112	30	2,3	2,3	NUM
bptjm-64	112	31	-	-	NOUN
bptjm-64	112	32	dioxygenase	dioxygenase	NOUN
bptjm-64	112	33	(	(	PUNCT
bptjm-64	112	34	ido	ido	PROPN
bptjm-64	112	35	)	)	PUNCT
bptjm-64	112	36	,	,	PUNCT
bptjm-64	112	37	the	the	DET
bptjm-64	112	38	enzyme	enzyme	NOUN
bptjm-64	112	39	that	that	PRON
bptjm-64	112	40	converts	convert	VERB
bptjm-64	112	41	tryptophan	tryptophan	NOUN
bptjm-64	112	42	to	to	ADP
bptjm-64	112	43	kynurenine.5	kynurenine.5	ADJ
bptjm-64	112	44	kynurenine	kynurenine	NOUN
bptjm-64	112	45	has	have	VERB
bptjm-64	112	46	immunosuppressive	immunosuppressive	ADJ
bptjm-64	112	47	e	e	NOUN
bptjm-64	112	48	�	�	NOUN
bptjm-64	112	49	ects	ect	VERB
bptjm-64	112	50	on	on	ADP
bptjm-64	112	51	t	t	NOUN
bptjm-64	112	52	cells	cell	NOUN
bptjm-64	112	53	,	,	PUNCT
bptjm-64	112	54	so	so	ADV
bptjm-64	112	55	targeting	target	VERB
bptjm-64	112	56	ido	ido	NOUN
bptjm-64	112	57	activity	activity	NOUN
bptjm-64	112	58	could	could	AUX
bptjm-64	112	59	not	not	PART
bptjm-64	112	60	only	only	ADV
bptjm-64	112	61	mitigate	mitigate	VERB
bptjm-64	112	62	these	these	DET
bptjm-64	112	63	immunosuppressive	immunosuppressive	ADJ
bptjm-64	112	64	e	e	NOUN
bptjm-64	112	65	�	�	NOUN
bptjm-64	112	66	ects	ect	VERB
bptjm-64	112	67	on	on	ADP
bptjm-64	112	68	t	t	NOUN
bptjm-64	112	69	cells	cell	NOUN
bptjm-64	112	70	but	but	CCONJ
bptjm-64	112	71	also	also	ADV
bptjm-64	112	72	inhibit	inhibit	VERB
bptjm-64	112	73	these	these	DET
bptjm-64	112	74	adaptive	adaptive	ADJ
bptjm-64	112	75	immune	immune	ADJ
bptjm-64	112	76	cell	cell	NOUN
bptjm-64	112	77	subsets.5	subsets.5	PROPN
bptjm-64	112	78	lipid	lipid	NOUN
bptjm-64	112	79	metabolism	metabolism	NOUN
bptjm-64	112	80	has	have	AUX
bptjm-64	112	81	emerged	emerge	VERB
bptjm-64	112	82	as	as	ADP
bptjm-64	112	83	a	a	DET
bptjm-64	112	84	recent	recent	ADJ
bptjm-64	112	85	target	target	NOUN
bptjm-64	112	86	in	in	ADP
bptjm-64	112	87	immunotherapy	immunotherapy	NOUN
bptjm-64	112	88	.	.	PUNCT
bptjm-64	113	1	cancer	cancer	NOUN
bptjm-64	113	2	cells	cell	NOUN
bptjm-64	113	3	exploit	exploit	VERB
bptjm-64	113	4	lipid	lipid	ADJ
bptjm-64	113	5	metabolism	metabolism	NOUN
bptjm-64	113	6	to	to	PART
bptjm-64	113	7	support	support	VERB
bptjm-64	113	8	their	their	PRON
bptjm-64	113	9	rapid	rapid	ADJ
bptjm-64	113	10	proliferation	proliferation	NOUN
bptjm-64	113	11	,	,	PUNCT
bptjm-64	113	12	survival	survival	NOUN
bptjm-64	113	13	,	,	PUNCT
bptjm-64	113	14	migration	migration	NOUN
bptjm-64	113	15	,	,	PUNCT
bptjm-64	113	16	invasion	invasion	NOUN
bptjm-64	113	17	,	,	PUNCT
bptjm-64	113	18	and	and	CCONJ
bptjm-64	113	19	metastasis.26	metastasis.26	ADJ
bptjm-64	113	20	reprogramming	reprogramming	NOUN
bptjm-64	113	21	lipid	lipid	NOUN
bptjm-64	113	22	metabolism	metabolism	NOUN
bptjm-64	113	23	can	can	AUX
bptjm-64	113	24	berkeley	berkeley	PROPN
bptjm-64	113	25	pharma	pharma	PROPN
bptjm-64	113	26	tech	tech	NOUN
bptjm-64	113	27	journal	journal	NOUN
bptjm-64	113	28	of	of	ADP
bptjm-64	113	29	medicine	medicine	NOUN
bptjm-64	113	30	|	|	ADV
bptjm-64	113	31	127	127	NUM
bptjm-64	113	32	prevent	prevent	NOUN
bptjm-64	113	33	e	e	NOUN
bptjm-64	113	34	�	�	PROPN
bptjm-64	113	35	ector	ector	PROPN
bptjm-64	113	36	t	t	PROPN
bptjm-64	113	37	cell	cell	NOUN
bptjm-64	113	38	senescence	senescence	NOUN
bptjm-64	113	39	,	,	PUNCT
bptjm-64	113	40	suggesting	suggest	VERB
bptjm-64	113	41	that	that	SCONJ
bptjm-64	113	42	lipid	lipid	ADJ
bptjm-64	113	43	metabolism	metabolism	NOUN
bptjm-64	113	44	plays	play	VERB
bptjm-64	113	45	a	a	DET
bptjm-64	113	46	role	role	NOUN
bptjm-64	113	47	in	in	ADP
bptjm-64	113	48	regulating	regulate	VERB
bptjm-64	113	49	senescence	senescence	NOUN
bptjm-64	113	50	development	development	NOUN
bptjm-64	113	51	in	in	ADP
bptjm-64	113	52	t	t	PROPN
bptjm-64	113	53	cells.27	cells.27	PROPN
bptjm-64	113	54	fatty	fatty	PROPN
bptjm-64	113	55	acid	acid	PROPN
bptjm-64	113	56	metabolism	metabolism	NOUN
bptjm-64	113	57	is	be	AUX
bptjm-64	113	58	crucial	crucial	ADJ
bptjm-64	113	59	for	for	ADP
bptjm-64	113	60	the	the	DET
bptjm-64	113	61	di	di	PROPN
bptjm-64	113	62	�	�	PROPN
bptjm-64	113	63	erentiation	erentiation	NOUN
bptjm-64	113	64	of	of	ADP
bptjm-64	113	65	immune	immune	ADJ
bptjm-64	113	66	cells	cell	NOUN
bptjm-64	113	67	,	,	PUNCT
bptjm-64	113	68	and	and	CCONJ
bptjm-64	113	69	the	the	DET
bptjm-64	113	70	upregulation	upregulation	NOUN
bptjm-64	113	71	of	of	ADP
bptjm-64	113	72	fatty	fatty	NOUN
bptjm-64	113	73	acid	acid	NOUN
bptjm-64	113	74	oxidation	oxidation	NOUN
bptjm-64	113	75	(	(	PUNCT
bptjm-64	113	76	fao	fao	NOUN
bptjm-64	113	77	)	)	PUNCT
bptjm-64	113	78	can	can	AUX
bptjm-64	113	79	enhance	enhance	VERB
bptjm-64	113	80	the	the	DET
bptjm-64	113	81	functions	function	NOUN
bptjm-64	113	82	of	of	ADP
bptjm-64	113	83	cd8	cd8	PROPN
bptjm-64	113	84	+	+	PROPN
bptjm-64	113	85	t	t	NOUN
bptjm-64	113	86	cells	cell	NOUN
bptjm-64	113	87	.	.	PUNCT
bptjm-64	114	1	reprogramming	reprogramme	VERB
bptjm-64	114	2	fatty	fatty	NOUN
bptjm-64	114	3	acid	acid	ADJ
bptjm-64	114	4	metabolism	metabolism	NOUN
bptjm-64	114	5	in	in	ADP
bptjm-64	114	6	immune	immune	ADJ
bptjm-64	114	7	cells	cell	NOUN
bptjm-64	114	8	could	could	AUX
bptjm-64	114	9	promote	promote	VERB
bptjm-64	114	10	an	an	DET
bptjm-64	114	11	inhibitory	inhibitory	ADJ
bptjm-64	114	12	immune	immune	ADJ
bptjm-64	114	13	microenvironment.28	microenvironment.28	NOUN
bptjm-64	114	14	it	it	PRON
bptjm-64	114	15	is	be	AUX
bptjm-64	114	16	often	often	ADV
bptjm-64	114	17	used	use	VERB
bptjm-64	114	18	in	in	ADP
bptjm-64	114	19	combination	combination	NOUN
bptjm-64	114	20	therapies	therapy	NOUN
bptjm-64	114	21	with	with	ADP
bptjm-64	114	22	other	other	ADJ
bptjm-64	114	23	immunotherapeutic	immunotherapeutic	ADJ
bptjm-64	114	24	treatments	treatment	NOUN
bptjm-64	114	25	,	,	PUNCT
bptjm-64	114	26	such	such	ADJ
bptjm-64	114	27	as	as	ADP
bptjm-64	114	28	immune	immune	ADJ
bptjm-64	114	29	checkpoint	checkpoint	NOUN
bptjm-64	114	30	blockades	blockade	NOUN
bptjm-64	114	31	(	(	PUNCT
bptjm-64	114	32	icbs).28	icbs).28	X
bptjm-64	114	33	recent	recent	ADJ
bptjm-64	114	34	studies	study	NOUN
bptjm-64	114	35	have	have	AUX
bptjm-64	114	36	shown	show	VERB
bptjm-64	114	37	that	that	SCONJ
bptjm-64	114	38	targeting	target	VERB
bptjm-64	114	39	fatty	fatty	NOUN
bptjm-64	114	40	acid	acid	NOUN
bptjm-64	114	41	metabolism	metabolism	NOUN
bptjm-64	114	42	in	in	ADP
bptjm-64	114	43	t	t	PROPN
bptjm-64	114	44	cells	cell	NOUN
bptjm-64	114	45	can	can	AUX
bptjm-64	114	46	improve	improve	VERB
bptjm-64	114	47	the	the	DET
bptjm-64	114	48	e	e	PROPN
bptjm-64	114	49	�	�	PROPN
bptjm-64	114	50	cacy	cacy	NOUN
bptjm-64	114	51	of	of	ADP
bptjm-64	114	52	icbs	icbs	PROPN
bptjm-64	114	53	.	.	PUNCT
bptjm-64	115	1	for	for	ADP
bptjm-64	115	2	instance	instance	NOUN
bptjm-64	115	3	,	,	PUNCT
bptjm-64	115	4	a	a	DET
bptjm-64	115	5	study	study	NOUN
bptjm-64	115	6	found	find	VERB
bptjm-64	115	7	that	that	SCONJ
bptjm-64	115	8	combining	combine	VERB
bptjm-64	115	9	beza	beza	PROPN
bptjm-64	115	10	�	�	PROPN
bptjm-64	115	11	brate	brate	PROPN
bptjm-64	115	12	with	with	ADP
bptjm-64	115	13	pd	pd	PROPN
bptjm-64	115	14	-	-	PUNCT
bptjm-64	115	15	l1	l1	PROPN
bptjm-64	115	16	antibody	antibody	NOUN
bptjm-64	115	17	treatment	treatment	NOUN
bptjm-64	115	18	yielded	yield	VERB
bptjm-64	115	19	better	well	ADJ
bptjm-64	115	20	results	result	NOUN
bptjm-64	115	21	in	in	ADP
bptjm-64	115	22	llc	llc	PROPN
bptjm-64	115	23	xenograft	xenograft	PROPN
bptjm-64	115	24	mouse	mouse	PROPN
bptjm-64	115	25	models	model	NOUN
bptjm-64	115	26	.	.	PUNCT
bptjm-64	116	1	beza	beza	PROPN
bptjm-64	116	2	�	�	PROPN
bptjm-64	116	3	brate	brate	PROPN
bptjm-64	116	4	treatments	treatment	NOUN
bptjm-64	116	5	increased	increase	VERB
bptjm-64	116	6	the	the	DET
bptjm-64	116	7	expression	expression	NOUN
bptjm-64	116	8	of	of	ADP
bptjm-64	116	9	fao	fao	NOUN
bptjm-64	116	10	-	-	PUNCT
bptjm-64	116	11	related	relate	VERB
bptjm-64	116	12	genes	gene	NOUN
bptjm-64	116	13	in	in	ADP
bptjm-64	116	14	cytotoxic	cytotoxic	ADJ
bptjm-64	116	15	t	t	NOUN
bptjm-64	116	16	lymphocytes	lymphocyte	NOUN
bptjm-64	116	17	(	(	PUNCT
bptjm-64	116	18	ctls	ctls	PROPN
bptjm-64	116	19	)	)	PUNCT
bptjm-64	116	20	,	,	PUNCT
bptjm-64	116	21	such	such	ADJ
bptjm-64	116	22	as	as	ADP
bptjm-64	116	23	pgc-1α	pgc-1α	NOUN
bptjm-64	116	24	,	,	PUNCT
bptjm-64	116	25	cpt1a	cpt1a	NUM
bptjm-64	116	26	,	,	PUNCT
bptjm-64	116	27	and	and	CCONJ
bptjm-64	116	28	lcad	lcad	NOUN
bptjm-64	116	29	,	,	PUNCT
bptjm-64	116	30	and	and	CCONJ
bptjm-64	116	31	maintained	maintain	VERB
bptjm-64	116	32	the	the	DET
bptjm-64	116	33	survival	survival	NOUN
bptjm-64	116	34	and	and	CCONJ
bptjm-64	116	35	function	function	NOUN
bptjm-64	116	36	of	of	ADP
bptjm-64	116	37	ctls.29	ctls.29	NOUN
bptjm-64	116	38	scientists	scientist	NOUN
bptjm-64	116	39	have	have	AUX
bptjm-64	116	40	explored	explore	VERB
bptjm-64	116	41	manipulating	manipulate	VERB
bptjm-64	116	42	iron	iron	NOUN
bptjm-64	116	43	metabolism	metabolism	NOUN
bptjm-64	116	44	as	as	ADP
bptjm-64	116	45	a	a	DET
bptjm-64	116	46	strategy	strategy	NOUN
bptjm-64	116	47	for	for	ADP
bptjm-64	116	48	treating	treat	VERB
bptjm-64	116	49	tumors	tumor	NOUN
bptjm-64	116	50	,	,	PUNCT
bptjm-64	116	51	given	give	VERB
bptjm-64	116	52	iron	iron	NOUN
bptjm-64	116	53	's	's	PART
bptjm-64	116	54	crucial	crucial	ADJ
bptjm-64	116	55	role	role	NOUN
bptjm-64	116	56	in	in	ADP
bptjm-64	116	57	tumor	tumor	NOUN
bptjm-64	116	58	proliferation	proliferation	NOUN
bptjm-64	116	59	.	.	PUNCT
bptjm-64	117	1	iron	iron	NOUN
bptjm-64	117	2	metabolic	metabolic	NOUN
bptjm-64	117	3	dysfunction	dysfunction	NOUN
bptjm-64	117	4	directly	directly	ADV
bptjm-64	117	5	impacts	impact	VERB
bptjm-64	117	6	cancer	cancer	NOUN
bptjm-64	117	7	pathophysiology	pathophysiology	NOUN
bptjm-64	117	8	,	,	PUNCT
bptjm-64	117	9	with	with	ADP
bptjm-64	117	10	the	the	DET
bptjm-64	117	11	availability	availability	NOUN
bptjm-64	117	12	of	of	ADP
bptjm-64	117	13	iron	iron	NOUN
bptjm-64	117	14	regulating	regulate	VERB
bptjm-64	117	15	the	the	DET
bptjm-64	117	16	aggressive	aggressive	ADJ
bptjm-64	117	17	phenotypes	phenotype	NOUN
bptjm-64	117	18	of	of	ADP
bptjm-64	117	19	tumors.30	tumors.30	NOUN
bptjm-64	117	20	many	many	ADJ
bptjm-64	117	21	tumor	tumor	NOUN
bptjm-64	117	22	microenvironment	microenvironment	NOUN
bptjm-64	117	23	(	(	PUNCT
bptjm-64	117	24	tme	tme	NOUN
bptjm-64	117	25	)	)	PUNCT
bptjm-64	117	26	cells	cell	NOUN
bptjm-64	117	27	rely	rely	VERB
bptjm-64	117	28	on	on	ADP
bptjm-64	117	29	iron	iron	NOUN
bptjm-64	117	30	to	to	PART
bptjm-64	117	31	thrive	thrive	VERB
bptjm-64	117	32	and	and	CCONJ
bptjm-64	117	33	function	function	VERB
bptjm-64	117	34	properly	properly	ADV
bptjm-64	117	35	.	.	PUNCT
bptjm-64	118	1	for	for	ADP
bptjm-64	118	2	instance	instance	NOUN
bptjm-64	118	3	,	,	PUNCT
bptjm-64	118	4	activated	activate	VERB
bptjm-64	118	5	m2	m2	PROPN
bptjm-64	118	6	tumor	tumor	NOUN
bptjm-64	118	7	-	-	PUNCT
bptjm-64	118	8	associated	associate	VERB
bptjm-64	118	9	macrophages	macrophage	NOUN
bptjm-64	118	10	(	(	PUNCT
bptjm-64	118	11	tams	tam	NOUN
bptjm-64	118	12	)	)	PUNCT
bptjm-64	118	13	can	can	AUX
bptjm-64	118	14	disrupt	disrupt	VERB
bptjm-64	118	15	iron	iron	NOUN
bptjm-64	118	16	homeostasis	homeostasis	NOUN
bptjm-64	118	17	within	within	ADP
bptjm-64	118	18	tumor	tumor	NOUN
bptjm-64	118	19	cells	cell	NOUN
bptjm-64	118	20	by	by	ADP
bptjm-64	118	21	exporting	export	VERB
bptjm-64	118	22	high	high	ADJ
bptjm-64	118	23	amounts	amount	NOUN
bptjm-64	118	24	of	of	ADP
bptjm-64	118	25	iron	iron	NOUN
bptjm-64	118	26	and	and	CCONJ
bptjm-64	118	27	increasing	increase	VERB
bptjm-64	118	28	the	the	DET
bptjm-64	118	29	production	production	NOUN
bptjm-64	118	30	of	of	ADP
bptjm-64	118	31	other	other	ADJ
bptjm-64	118	32	iron	iron	NOUN
bptjm-64	118	33	-	-	PUNCT
bptjm-64	118	34	related	relate	VERB
bptjm-64	118	35	proteins.30	proteins.30	NOUN
bptjm-64	118	36	it	it	PRON
bptjm-64	118	37	has	have	AUX
bptjm-64	118	38	been	be	AUX
bptjm-64	118	39	observed	observe	VERB
bptjm-64	118	40	that	that	SCONJ
bptjm-64	118	41	iron	iron	NOUN
bptjm-64	118	42	chelation	chelation	NOUN
bptjm-64	118	43	,	,	PUNCT
bptjm-64	118	44	the	the	DET
bptjm-64	118	45	bonding	bonding	NOUN
bptjm-64	118	46	of	of	ADP
bptjm-64	118	47	ionic	ionic	ADJ
bptjm-64	118	48	molecules	molecule	NOUN
bptjm-64	118	49	to	to	ADP
bptjm-64	118	50	metal	metal	NOUN
bptjm-64	118	51	ions	ion	NOUN
bptjm-64	118	52	,	,	PUNCT
bptjm-64	118	53	can	can	AUX
bptjm-64	118	54	reverse	reverse	VERB
bptjm-64	118	55	the	the	DET
bptjm-64	118	56	iron	iron	NOUN
bptjm-64	118	57	-	-	PUNCT
bptjm-64	118	58	exporting	export	VERB
bptjm-64	118	59	phenotype	phenotype	NOUN
bptjm-64	118	60	of	of	ADP
bptjm-64	118	61	m2	m2	PROPN
bptjm-64	118	62	tams.30	tams.30	NOUN
bptjm-64	118	63	blocking	block	VERB
bptjm-64	118	64	transferrin	transferrin	NOUN
bptjm-64	118	65	receptor	receptor	NOUN
bptjm-64	118	66	1	1	NUM
bptjm-64	118	67	(	(	PUNCT
bptjm-64	118	68	tfr1	tfr1	PROPN
bptjm-64	118	69	)	)	PUNCT
bptjm-64	118	70	,	,	PUNCT
bptjm-64	118	71	a	a	DET
bptjm-64	118	72	receptor	receptor	NOUN
bptjm-64	118	73	protein	protein	NOUN
bptjm-64	118	74	that	that	PRON
bptjm-64	118	75	recognizes	recognize	VERB
bptjm-64	118	76	transferrin	transferrin	NOUN
bptjm-64	118	77	-	-	PUNCT
bptjm-64	118	78	bound	bind	VERB
bptjm-64	118	79	iron	iron	NOUN
bptjm-64	118	80	,	,	PUNCT
bptjm-64	118	81	has	have	AUX
bptjm-64	118	82	proven	prove	VERB
bptjm-64	118	83	e	e	NOUN
bptjm-64	118	84	�	�	NOUN
bptjm-64	118	85	ective	ective	ADJ
bptjm-64	118	86	in	in	ADP
bptjm-64	118	87	suppressing	suppress	VERB
bptjm-64	118	88	tumor	tumor	NOUN
bptjm-64	118	89	growth	growth	NOUN
bptjm-64	118	90	,	,	PUNCT
bptjm-64	118	91	as	as	SCONJ
bptjm-64	118	92	tfr1	tfr1	NOUN
bptjm-64	118	93	is	be	AUX
bptjm-64	118	94	often	often	ADV
bptjm-64	118	95	upregulated	upregulate	VERB
bptjm-64	118	96	in	in	ADP
bptjm-64	118	97	cancer	cancer	NOUN
bptjm-64	118	98	cells	cell	NOUN
bptjm-64	118	99	to	to	PART
bptjm-64	118	100	enhance	enhance	VERB
bptjm-64	118	101	their	their	PRON
bptjm-64	118	102	iron	iron	NOUN
bptjm-64	118	103	supply.30	supply.30	NOUN
bptjm-64	118	104	thus	thus	ADV
bptjm-64	118	105	,	,	PUNCT
bptjm-64	118	106	cutting	cut	VERB
bptjm-64	118	107	o	o	NOUN
bptjm-64	118	108	�	�	PROPN
bptjm-64	118	109	a	a	DET
bptjm-64	118	110	tumor	tumor	NOUN
bptjm-64	118	111	's	's	PART
bptjm-64	118	112	iron	iron	NOUN
bptjm-64	118	113	supply	supply	NOUN
bptjm-64	118	114	appears	appear	VERB
bptjm-64	118	115	to	to	PART
bptjm-64	118	116	be	be	AUX
bptjm-64	118	117	an	an	DET
bptjm-64	118	118	e	e	NOUN
bptjm-64	118	119	�	�	NOUN
bptjm-64	118	120	ective	ective	ADJ
bptjm-64	118	121	method	method	NOUN
bptjm-64	118	122	to	to	PART
bptjm-64	118	123	reduce	reduce	VERB
bptjm-64	118	124	tumor	tumor	NOUN
bptjm-64	118	125	growth	growth	NOUN
bptjm-64	118	126	.	.	PUNCT
bptjm-64	119	1	berkeley	berkeley	PROPN
bptjm-64	119	2	pharma	pharma	PROPN
bptjm-64	119	3	tech	tech	PROPN
bptjm-64	119	4	journal	journal	NOUN
bptjm-64	119	5	of	of	ADP
bptjm-64	119	6	medicine	medicine	NOUN
bptjm-64	119	7	|	|	ADV
bptjm-64	119	8	128	128	NUM
bptjm-64	119	9	figure	figure	NOUN
bptjm-64	119	10	3	3	NUM
bptjm-64	119	11	:	:	PUNCT
bptjm-64	119	12	the	the	DET
bptjm-64	119	13	interactions	interaction	NOUN
bptjm-64	119	14	between	between	ADP
bptjm-64	119	15	tryptophan	tryptophan	NOUN
bptjm-64	119	16	and	and	CCONJ
bptjm-64	119	17	kynurenine	kynurenine	NOUN
bptjm-64	119	18	.	.	PUNCT
bptjm-64	120	1	the	the	DET
bptjm-64	120	2	enzyme	enzyme	NOUN
bptjm-64	120	3	ido	ido	NOUN
bptjm-64	120	4	converts	convert	VERB
bptjm-64	120	5	tryptophan	tryptophan	NOUN
bptjm-64	120	6	into	into	ADP
bptjm-64	120	7	kynurenine	kynurenine	NOUN
bptjm-64	120	8	,	,	PUNCT
bptjm-64	120	9	which	which	PRON
bptjm-64	120	10	exerts	exert	VERB
bptjm-64	120	11	an	an	DET
bptjm-64	120	12	immunosuppressive	immunosuppressive	ADJ
bptjm-64	120	13	effect	effect	NOUN
bptjm-64	120	14	on	on	ADP
bptjm-64	120	15	t	t	NOUN
bptjm-64	120	16	cells	cell	NOUN
bptjm-64	120	17	.	.	PUNCT
bptjm-64	121	1	blocking	block	VERB
bptjm-64	121	2	ido	ido	NOUN
bptjm-64	121	3	would	would	AUX
bptjm-64	121	4	not	not	PART
bptjm-64	121	5	only	only	ADV
bptjm-64	121	6	eliminate	eliminate	VERB
bptjm-64	121	7	the	the	DET
bptjm-64	121	8	immunosuppressive	immunosuppressive	ADJ
bptjm-64	121	9	effect	effect	NOUN
bptjm-64	121	10	on	on	ADP
bptjm-64	121	11	t	t	NOUN
bptjm-64	121	12	cells	cell	NOUN
bptjm-64	121	13	but	but	CCONJ
bptjm-64	121	14	also	also	ADV
bptjm-64	121	15	suppress	suppress	VERB
bptjm-64	121	16	adaptive	adaptive	ADJ
bptjm-64	121	17	immune	immune	ADJ
bptjm-64	121	18	cell	cell	NOUN
bptjm-64	121	19	subsets	subset	NOUN
bptjm-64	121	20	,	,	PUNCT
bptjm-64	121	21	including	include	VERB
bptjm-64	121	22	mdscs	mdsc	NOUN
bptjm-64	121	23	,	,	PUNCT
bptjm-64	121	24	tregs	treg	NOUN
bptjm-64	121	25	,	,	PUNCT
bptjm-64	121	26	and	and	CCONJ
bptjm-64	121	27	dcs	dcs	PROPN
bptjm-64	121	28	.	.	PROPN
bptjm-64	122	1	4.3	4.3	NUM
bptjm-64	122	2	targeting	target	VERB
bptjm-64	122	3	signaling	signal	VERB
bptjm-64	122	4	pathways	pathway	NOUN
bptjm-64	122	5	di	di	NOUN
bptjm-64	122	6	�	�	PROPN
bptjm-64	122	7	erent	erent	NOUN
bptjm-64	122	8	signaling	signal	VERB
bptjm-64	122	9	pathways	pathway	NOUN
bptjm-64	122	10	,	,	PUNCT
bptjm-64	122	11	such	such	ADJ
bptjm-64	122	12	as	as	ADP
bptjm-64	122	13	oxygen	oxygen	NOUN
bptjm-64	122	14	and	and	CCONJ
bptjm-64	122	15	nutrient	nutrient	NOUN
bptjm-64	122	16	sensing	sense	VERB
bptjm-64	122	17	pathways	pathway	NOUN
bptjm-64	122	18	,	,	PUNCT
bptjm-64	122	19	have	have	AUX
bptjm-64	122	20	signi	signi	ADJ
bptjm-64	122	21	�	�	NOUN
bptjm-64	122	22	cant	cant	NOUN
bptjm-64	122	23	potential	potential	NOUN
bptjm-64	122	24	for	for	ADP
bptjm-64	122	25	reducing	reduce	VERB
bptjm-64	122	26	the	the	DET
bptjm-64	122	27	glucose	glucose	NOUN
bptjm-64	122	28	metabolism	metabolism	NOUN
bptjm-64	122	29	of	of	ADP
bptjm-64	122	30	cancer	cancer	NOUN
bptjm-64	122	31	cells	cell	NOUN
bptjm-64	122	32	.	.	PUNCT
bptjm-64	123	1	in	in	ADP
bptjm-64	123	2	low	low	ADJ
bptjm-64	123	3	-	-	PUNCT
bptjm-64	123	4	glucose	glucose	NOUN
bptjm-64	123	5	environments	environment	NOUN
bptjm-64	123	6	,	,	PUNCT
bptjm-64	123	7	amp	amp	NOUN
bptjm-64	123	8	-	-	PUNCT
bptjm-64	123	9	activated	activate	VERB
bptjm-64	123	10	protein	protein	NOUN
bptjm-64	123	11	kinase	kinase	NOUN
bptjm-64	123	12	(	(	PUNCT
bptjm-64	123	13	ampk	ampk	NOUN
bptjm-64	123	14	)	)	PUNCT
bptjm-64	123	15	becomes	become	VERB
bptjm-64	123	16	activated	activate	VERB
bptjm-64	123	17	,	,	PUNCT
bptjm-64	123	18	and	and	CCONJ
bptjm-64	123	19	in	in	ADP
bptjm-64	123	20	high	high	ADJ
bptjm-64	123	21	-	-	PUNCT
bptjm-64	123	22	glucose	glucose	NOUN
bptjm-64	123	23	environments	environment	NOUN
bptjm-64	123	24	,	,	PUNCT
bptjm-64	123	25	ampk	ampk	NOUN
bptjm-64	123	26	is	be	AUX
bptjm-64	123	27	promoted	promote	VERB
bptjm-64	123	28	,	,	PUNCT
bptjm-64	123	29	which	which	PRON
bptjm-64	123	30	can	can	AUX
bptjm-64	123	31	lead	lead	VERB
bptjm-64	123	32	to	to	ADP
bptjm-64	123	33	the	the	DET
bptjm-64	123	34	persistence	persistence	NOUN
bptjm-64	123	35	of	of	ADP
bptjm-64	123	36	immunosuppressive	immunosuppressive	ADJ
bptjm-64	123	37	cells.5	cells.5	PROPN
bptjm-64	123	38	high	high	ADJ
bptjm-64	123	39	levels	level	NOUN
bptjm-64	123	40	of	of	ADP
bptjm-64	123	41	ampk	ampk	NOUN
bptjm-64	123	42	can	can	AUX
bptjm-64	123	43	inhibit	inhibit	VERB
bptjm-64	123	44	t	t	NOUN
bptjm-64	123	45	cells	cell	NOUN
bptjm-64	123	46	,	,	PUNCT
bptjm-64	123	47	but	but	CCONJ
bptjm-64	123	48	disabling	disable	VERB
bptjm-64	123	49	ampk	ampk	NOUN
bptjm-64	123	50	may	may	AUX
bptjm-64	123	51	result	result	VERB
bptjm-64	123	52	in	in	ADP
bptjm-64	123	53	increased	increase	VERB
bptjm-64	123	54	glycolysis	glycolysis	NOUN
bptjm-64	123	55	in	in	ADP
bptjm-64	123	56	cancer	cancer	NOUN
bptjm-64	123	57	cells	cell	NOUN
bptjm-64	123	58	.	.	PUNCT
bptjm-64	124	1	metformin	metformin	NOUN
bptjm-64	124	2	is	be	AUX
bptjm-64	124	3	one	one	NUM
bptjm-64	124	4	drug	drug	NOUN
bptjm-64	124	5	that	that	PRON
bptjm-64	124	6	targets	target	VERB
bptjm-64	124	7	ampk	ampk	NOUN
bptjm-64	124	8	by	by	ADP
bptjm-64	124	9	activating	activate	VERB
bptjm-64	124	10	its	its	PRON
bptjm-64	124	11	signaling	signaling	NOUN
bptjm-64	124	12	.	.	PUNCT
bptjm-64	125	1	studies	study	NOUN
bptjm-64	125	2	have	have	AUX
bptjm-64	125	3	shown	show	VERB
bptjm-64	125	4	that	that	SCONJ
bptjm-64	125	5	metformin	metformin	NOUN
bptjm-64	125	6	reduces	reduce	VERB
bptjm-64	125	7	cancer	cancer	NOUN
bptjm-64	125	8	risk	risk	NOUN
bptjm-64	125	9	in	in	ADP
bptjm-64	125	10	both	both	DET
bptjm-64	125	11	mice	mouse	NOUN
bptjm-64	125	12	models	model	NOUN
bptjm-64	125	13	and	and	CCONJ
bptjm-64	125	14	humans	human	NOUN
bptjm-64	125	15	.	.	PUNCT
bptjm-64	126	1	ampk	ampk	NOUN
bptjm-64	126	2	activation	activation	NOUN
bptjm-64	126	3	is	be	AUX
bptjm-64	126	4	believed	believe	VERB
bptjm-64	126	5	to	to	PART
bptjm-64	126	6	reduce	reduce	VERB
bptjm-64	126	7	tumor	tumor	NOUN
bptjm-64	126	8	burden	burden	NOUN
bptjm-64	126	9	by	by	ADP
bptjm-64	126	10	slowing	slow	VERB
bptjm-64	126	11	tumor	tumor	NOUN
bptjm-64	126	12	growth	growth	NOUN
bptjm-64	126	13	,	,	PUNCT
bptjm-64	126	14	supporting	support	VERB
bptjm-64	126	15	the	the	DET
bptjm-64	126	16	growth	growth	NOUN
bptjm-64	126	17	of	of	ADP
bptjm-64	126	18	tumor	tumor	NOUN
bptjm-64	126	19	-	-	PUNCT
bptjm-64	126	20	in	in	ADP
bptjm-64	126	21	�	�	NOUN
bptjm-64	126	22	ltrating	ltrating	NOUN
bptjm-64	126	23	lymphocytes	lymphocyte	NOUN
bptjm-64	126	24	(	(	PUNCT
bptjm-64	126	25	tils	til	NOUN
bptjm-64	126	26	)	)	PUNCT
bptjm-64	126	27	in	in	ADP
bptjm-64	126	28	the	the	DET
bptjm-64	126	29	tumor	tumor	NOUN
bptjm-64	126	30	microenvironment	microenvironment	NOUN
bptjm-64	126	31	(	(	PUNCT
bptjm-64	126	32	tme	tme	NOUN
bptjm-64	126	33	)	)	PUNCT
bptjm-64	126	34	,	,	PUNCT
bptjm-64	126	35	and	and	CCONJ
bptjm-64	126	36	blocking	block	VERB
bptjm-64	126	37	certain	certain	ADJ
bptjm-64	126	38	glycolytic	glycolytic	ADJ
bptjm-64	126	39	enzymes	enzyme	NOUN
bptjm-64	126	40	necessary	necessary	ADJ
bptjm-64	126	41	for	for	ADP
bptjm-64	126	42	cancer	cancer	NOUN
bptjm-64	126	43	cell	cell	NOUN
bptjm-64	126	44	berkeley	berkeley	PROPN
bptjm-64	126	45	pharma	pharma	PROPN
bptjm-64	126	46	tech	tech	NOUN
bptjm-64	126	47	journal	journal	NOUN
bptjm-64	126	48	of	of	ADP
bptjm-64	126	49	medicine	medicine	NOUN
bptjm-64	126	50	|	|	ADV
bptjm-64	126	51	129	129	NUM
bptjm-64	126	52	proliferation	proliferation	NOUN
bptjm-64	126	53	.	.	PUNCT
bptjm-64	127	1	however	however	ADV
bptjm-64	127	2	,	,	PUNCT
bptjm-64	127	3	ampk	ampk	NOUN
bptjm-64	127	4	activation	activation	NOUN
bptjm-64	127	5	can	can	AUX
bptjm-64	127	6	also	also	ADV
bptjm-64	127	7	increase	increase	VERB
bptjm-64	127	8	the	the	DET
bptjm-64	127	9	number	number	NOUN
bptjm-64	127	10	of	of	ADP
bptjm-64	127	11	immunosuppressive	immunosuppressive	ADJ
bptjm-64	127	12	cells	cell	NOUN
bptjm-64	127	13	while	while	SCONJ
bptjm-64	127	14	promoting	promote	VERB
bptjm-64	127	15	tumor	tumor	NOUN
bptjm-64	127	16	regression.5	regression.5	NOUN
bptjm-64	127	17	it	it	PRON
bptjm-64	127	18	is	be	AUX
bptjm-64	127	19	crucial	crucial	ADJ
bptjm-64	127	20	to	to	PART
bptjm-64	127	21	examine	examine	VERB
bptjm-64	127	22	the	the	DET
bptjm-64	127	23	e	e	NOUN
bptjm-64	127	24	�	�	NOUN
bptjm-64	127	25	ects	ect	VERB
bptjm-64	127	26	on	on	ADP
bptjm-64	127	27	both	both	DET
bptjm-64	127	28	cancer	cancer	NOUN
bptjm-64	127	29	cells	cell	NOUN
bptjm-64	127	30	and	and	CCONJ
bptjm-64	127	31	the	the	DET
bptjm-64	127	32	phenotypic	phenotypic	ADJ
bptjm-64	127	33	ratios	ratio	NOUN
bptjm-64	127	34	of	of	ADP
bptjm-64	127	35	immune	immune	ADJ
bptjm-64	127	36	cells	cell	NOUN
bptjm-64	127	37	.	.	PUNCT
bptjm-64	128	1	another	another	DET
bptjm-64	128	2	crucial	crucial	ADJ
bptjm-64	128	3	nutrient	nutrient	NOUN
bptjm-64	128	4	pathway	pathway	NOUN
bptjm-64	128	5	is	be	AUX
bptjm-64	128	6	the	the	DET
bptjm-64	128	7	mtor	mtor	PROPN
bptjm-64	128	8	pathway	pathway	NOUN
bptjm-64	128	9	,	,	PUNCT
bptjm-64	128	10	which	which	PRON
bptjm-64	128	11	is	be	AUX
bptjm-64	128	12	activated	activate	VERB
bptjm-64	128	13	by	by	ADP
bptjm-64	128	14	high	high	ADJ
bptjm-64	128	15	levels	level	NOUN
bptjm-64	128	16	of	of	ADP
bptjm-64	128	17	glucose	glucose	NOUN
bptjm-64	128	18	and	and	CCONJ
bptjm-64	128	19	amino	amino	NOUN
bptjm-64	128	20	acids	acid	NOUN
bptjm-64	128	21	.	.	PUNCT
bptjm-64	129	1	in	in	ADP
bptjm-64	129	2	t	t	PROPN
bptjm-64	129	3	cells	cell	NOUN
bptjm-64	129	4	,	,	PUNCT
bptjm-64	129	5	mtor	mtor	PROPN
bptjm-64	129	6	supports	support	VERB
bptjm-64	129	7	glycolysis	glycolysis	NOUN
bptjm-64	129	8	,	,	PUNCT
bptjm-64	129	9	di	di	NOUN
bptjm-64	129	10	�	�	PROPN
bptjm-64	129	11	erentiation	erentiation	NOUN
bptjm-64	129	12	,	,	PUNCT
bptjm-64	129	13	and	and	CCONJ
bptjm-64	129	14	e	e	NOUN
bptjm-64	129	15	�	�	PROPN
bptjm-64	129	16	ector	ector	NOUN
bptjm-64	129	17	functions	function	NOUN
bptjm-64	129	18	.	.	PUNCT
bptjm-64	130	1	however	however	ADV
bptjm-64	130	2	,	,	PUNCT
bptjm-64	130	3	because	because	SCONJ
bptjm-64	130	4	mtor	mtor	PROPN
bptjm-64	130	5	enhances	enhance	VERB
bptjm-64	130	6	memory	memory	NOUN
bptjm-64	130	7	formation	formation	NOUN
bptjm-64	130	8	in	in	ADP
bptjm-64	130	9	cd8	cd8	PROPN
bptjm-64	130	10	+	+	PROPN
bptjm-64	130	11	t	t	PROPN
bptjm-64	130	12	cells	cell	NOUN
bptjm-64	130	13	while	while	SCONJ
bptjm-64	130	14	low	low	ADJ
bptjm-64	130	15	mtor	mtor	PROPN
bptjm-64	130	16	levels	level	NOUN
bptjm-64	130	17	boost	boost	VERB
bptjm-64	130	18	treg	treg	PROPN
bptjm-64	130	19	activity	activity	NOUN
bptjm-64	130	20	,	,	PUNCT
bptjm-64	130	21	it	it	PRON
bptjm-64	130	22	is	be	AUX
bptjm-64	130	23	vital	vital	ADJ
bptjm-64	130	24	to	to	PART
bptjm-64	130	25	balance	balance	VERB
bptjm-64	130	26	mtor	mtor	NOUN
bptjm-64	130	27	levels	level	NOUN
bptjm-64	130	28	to	to	PART
bptjm-64	130	29	enhance	enhance	VERB
bptjm-64	130	30	memory	memory	NOUN
bptjm-64	130	31	formation	formation	NOUN
bptjm-64	130	32	without	without	ADP
bptjm-64	130	33	promoting	promote	VERB
bptjm-64	130	34	treg	treg	PROPN
bptjm-64	130	35	activity.5	activity.5	PROPN
bptjm-64	130	36	like	like	ADP
bptjm-64	130	37	ampk	ampk	NOUN
bptjm-64	130	38	,	,	PUNCT
bptjm-64	130	39	the	the	DET
bptjm-64	130	40	mtor	mtor	NOUN
bptjm-64	130	41	signaling	signal	VERB
bptjm-64	130	42	pathway	pathway	NOUN
bptjm-64	130	43	has	have	VERB
bptjm-64	130	44	a	a	DET
bptjm-64	130	45	complex	complex	ADJ
bptjm-64	130	46	nature	nature	NOUN
bptjm-64	130	47	,	,	PUNCT
bptjm-64	130	48	necessitating	necessitate	VERB
bptjm-64	130	49	further	further	ADJ
bptjm-64	130	50	research	research	NOUN
bptjm-64	130	51	to	to	PART
bptjm-64	130	52	develop	develop	VERB
bptjm-64	130	53	nuanced	nuanced	ADJ
bptjm-64	130	54	methods	method	NOUN
bptjm-64	130	55	that	that	PRON
bptjm-64	130	56	induce	induce	VERB
bptjm-64	130	57	bene	bene	PROPN
bptjm-64	130	58	�	�	PROPN
bptjm-64	130	59	cial	cial	ADJ
bptjm-64	130	60	immune	immune	ADJ
bptjm-64	130	61	responses	response	NOUN
bptjm-64	130	62	without	without	ADP
bptjm-64	130	63	creating	create	VERB
bptjm-64	130	64	a	a	DET
bptjm-64	130	65	tumor	tumor	NOUN
bptjm-64	130	66	-	-	PUNCT
bptjm-64	130	67	protecting	protect	VERB
bptjm-64	130	68	immune	immune	ADJ
bptjm-64	130	69	environment.5	environment.5	PROPN
bptjm-64	130	70	two	two	NUM
bptjm-64	130	71	critical	critical	ADJ
bptjm-64	130	72	targets	target	NOUN
bptjm-64	130	73	of	of	ADP
bptjm-64	130	74	immunotherapy	immunotherapy	NOUN
bptjm-64	130	75	are	be	AUX
bptjm-64	130	76	the	the	DET
bptjm-64	130	77	immune	immune	ADJ
bptjm-64	130	78	checkpoint	checkpoint	NOUN
bptjm-64	130	79	pathways	pathway	NOUN
bptjm-64	130	80	pd-1	pd-1	ADP
bptjm-64	130	81	/	/	SYM
bptjm-64	130	82	pd	pd	NOUN
bptjm-64	130	83	-	-	PROPN
bptjm-64	130	84	l1	l1	PROPN
bptjm-64	130	85	and	and	CCONJ
bptjm-64	130	86	ctla-4	ctla-4	NOUN
bptjm-64	130	87	.	.	PUNCT
bptjm-64	131	1	anti	anti	ADJ
bptjm-64	131	2	-	-	ADJ
bptjm-64	131	3	ctla-4	ctla-4	NOUN
bptjm-64	131	4	antibodies	antibody	NOUN
bptjm-64	131	5	can	can	AUX
bptjm-64	131	6	deplete	deplete	VERB
bptjm-64	131	7	treg	treg	PROPN
bptjm-64	131	8	cells	cell	NOUN
bptjm-64	131	9	from	from	ADP
bptjm-64	131	10	the	the	DET
bptjm-64	131	11	tumor	tumor	NOUN
bptjm-64	131	12	microenvironment	microenvironment	NOUN
bptjm-64	131	13	(	(	PUNCT
bptjm-64	131	14	tme	tme	PROPN
bptjm-64	131	15	)	)	PUNCT
bptjm-64	131	16	,	,	PUNCT
bptjm-64	131	17	leading	lead	VERB
bptjm-64	131	18	to	to	ADP
bptjm-64	131	19	successful	successful	ADJ
bptjm-64	131	20	tumor	tumor	NOUN
bptjm-64	131	21	rejection	rejection	NOUN
bptjm-64	131	22	in	in	ADP
bptjm-64	131	23	animal	animal	NOUN
bptjm-64	131	24	studies.31	studies.31	NOUN
bptjm-64	131	25	pd-1	pd-1	NOUN
bptjm-64	131	26	/	/	SYM
bptjm-64	131	27	pd	pd	PROPN
bptjm-64	131	28	-	-	PROPN
bptjm-64	131	29	l1	l1	PROPN
bptjm-64	131	30	are	be	AUX
bptjm-64	131	31	involved	involve	VERB
bptjm-64	131	32	in	in	ADP
bptjm-64	131	33	signaling	signal	VERB
bptjm-64	131	34	mediated	mediate	VERB
bptjm-64	131	35	by	by	ADP
bptjm-64	131	36	antigen	antigen	ADJ
bptjm-64	131	37	recognition	recognition	NOUN
bptjm-64	131	38	through	through	ADP
bptjm-64	131	39	t	t	NOUN
bptjm-64	131	40	cell	cell	NOUN
bptjm-64	131	41	receptors.31	receptors.31	NOUN
bptjm-64	131	42	antibodies	antibodie	VERB
bptjm-64	131	43	that	that	PRON
bptjm-64	131	44	block	block	VERB
bptjm-64	131	45	the	the	DET
bptjm-64	131	46	pd-1	pd-1	NOUN
bptjm-64	131	47	/	/	SYM
bptjm-64	131	48	pd	pd	ADJ
bptjm-64	131	49	-	-	PUNCT
bptjm-64	131	50	l1	l1	PROPN
bptjm-64	131	51	checkpoint	checkpoint	NOUN
bptjm-64	131	52	have	have	AUX
bptjm-64	131	53	shown	show	VERB
bptjm-64	131	54	signi	signi	PROPN
bptjm-64	131	55	�	�	NOUN
bptjm-64	131	56	cant	cant	VERB
bptjm-64	131	57	therapeutic	therapeutic	ADJ
bptjm-64	131	58	e	e	NOUN
bptjm-64	131	59	�	�	NOUN
bptjm-64	131	60	ciency.31	ciency.31	VERB
bptjm-64	131	61	these	these	DET
bptjm-64	131	62	immune	immune	ADJ
bptjm-64	131	63	checkpoints	checkpoint	NOUN
bptjm-64	131	64	mainly	mainly	ADV
bptjm-64	131	65	function	function	VERB
bptjm-64	131	66	by	by	ADP
bptjm-64	131	67	suppressing	suppress	VERB
bptjm-64	131	68	the	the	DET
bptjm-64	131	69	metabolic	metabolic	NOUN
bptjm-64	131	70	reprogramming	reprogramming	NOUN
bptjm-64	131	71	of	of	ADP
bptjm-64	131	72	immune	immune	ADJ
bptjm-64	131	73	cells	cell	NOUN
bptjm-64	131	74	,	,	PUNCT
bptjm-64	131	75	inhibiting	inhibit	VERB
bptjm-64	131	76	glycolysis	glycolysis	NOUN
bptjm-64	131	77	,	,	PUNCT
bptjm-64	131	78	and	and	CCONJ
bptjm-64	131	79	increasing	increase	VERB
bptjm-64	131	80	lipolysis	lipolysis	NOUN
bptjm-64	131	81	.	.	PUNCT
bptjm-64	132	1	blocking	block	VERB
bptjm-64	132	2	these	these	DET
bptjm-64	132	3	pathways	pathway	NOUN
bptjm-64	132	4	promotes	promote	VERB
bptjm-64	132	5	anabolic	anabolic	ADJ
bptjm-64	132	6	metabolic	metabolic	NOUN
bptjm-64	132	7	pathways	pathway	NOUN
bptjm-64	132	8	and	and	CCONJ
bptjm-64	132	9	glycolysis	glycolysis	NOUN
bptjm-64	132	10	,	,	PUNCT
bptjm-64	132	11	thereby	thereby	ADV
bptjm-64	132	12	restoring	restore	VERB
bptjm-64	132	13	the	the	DET
bptjm-64	132	14	e	e	PROPN
bptjm-64	132	15	�	�	PROPN
bptjm-64	132	16	ector	ector	NOUN
bptjm-64	132	17	function	function	NOUN
bptjm-64	132	18	of	of	ADP
bptjm-64	132	19	tumor	tumor	NOUN
bptjm-64	132	20	-	-	PUNCT
bptjm-64	132	21	in	in	ADP
bptjm-64	132	22	�	�	NOUN
bptjm-64	132	23	ltrating	ltrating	NOUN
bptjm-64	132	24	lymphocytes	lymphocyte	NOUN
bptjm-64	132	25	(	(	PUNCT
bptjm-64	132	26	tils	til	NOUN
bptjm-64	132	27	)	)	PUNCT
bptjm-64	132	28	.	.	PUNCT
bptjm-64	133	1	antibodies	antibodie	VERB
bptjm-64	133	2	against	against	ADP
bptjm-64	133	3	ctla-4	ctla-4	NOUN
bptjm-64	133	4	,	,	PUNCT
bptjm-64	133	5	pd-1	pd-1	ADV
bptjm-64	133	6	,	,	PUNCT
bptjm-64	133	7	and	and	CCONJ
bptjm-64	133	8	pd	pd	PROPN
bptjm-64	133	9	-	-	PUNCT
bptjm-64	133	10	l1	l1	PROPN
bptjm-64	133	11	reverse	reverse	VERB
bptjm-64	133	12	the	the	DET
bptjm-64	133	13	glycolysis	glycolysis	NOUN
bptjm-64	133	14	restrictions	restriction	NOUN
bptjm-64	133	15	on	on	ADP
bptjm-64	133	16	t	t	NOUN
bptjm-64	133	17	cells	cell	NOUN
bptjm-64	133	18	,	,	PUNCT
bptjm-64	133	19	essentially	essentially	ADV
bptjm-64	133	20	restoring	restore	VERB
bptjm-64	133	21	t	t	NOUN
bptjm-64	133	22	-	-	PUNCT
bptjm-64	133	23	cell	cell	NOUN
bptjm-64	133	24	glycolysis	glycolysis	NOUN
bptjm-64	133	25	and	and	CCONJ
bptjm-64	133	26	interferon	interferon	ADJ
bptjm-64	133	27	production.6	production.6	VERB
bptjm-64	133	28	another	another	DET
bptjm-64	133	29	signaling	signal	VERB
bptjm-64	133	30	pathway	pathway	NOUN
bptjm-64	133	31	that	that	PRON
bptjm-64	133	32	has	have	AUX
bptjm-64	133	33	been	be	AUX
bptjm-64	133	34	extensively	extensively	ADV
bptjm-64	133	35	studied	study	VERB
bptjm-64	133	36	is	be	AUX
bptjm-64	133	37	the	the	DET
bptjm-64	133	38	csf-1	csf-1	ADJ
bptjm-64	133	39	/	/	SYM
bptjm-64	133	40	r	r	NOUN
bptjm-64	133	41	pathway	pathway	NOUN
bptjm-64	133	42	,	,	PUNCT
bptjm-64	133	43	which	which	PRON
bptjm-64	133	44	is	be	AUX
bptjm-64	133	45	expressed	express	VERB
bptjm-64	133	46	in	in	ADP
bptjm-64	133	47	myeloid	myeloid	ADJ
bptjm-64	133	48	cells	cell	NOUN
bptjm-64	133	49	.	.	PUNCT
bptjm-64	134	1	this	this	DET
bptjm-64	134	2	pathway	pathway	NOUN
bptjm-64	134	3	regulates	regulate	VERB
bptjm-64	134	4	the	the	DET
bptjm-64	134	5	in	in	ADP
bptjm-64	134	6	�	�	PROPN
bptjm-64	134	7	ltration	ltration	NOUN
bptjm-64	134	8	,	,	PUNCT
bptjm-64	134	9	phenotypic	phenotypic	ADJ
bptjm-64	134	10	and	and	CCONJ
bptjm-64	134	11	functional	functional	ADJ
bptjm-64	134	12	di	di	PROPN
bptjm-64	134	13	�	�	PROPN
bptjm-64	134	14	erentiation	erentiation	NOUN
bptjm-64	134	15	,	,	PUNCT
bptjm-64	134	16	and	and	CCONJ
bptjm-64	134	17	survival	survival	NOUN
bptjm-64	134	18	of	of	ADP
bptjm-64	134	19	myeloid	myeloid	ADJ
bptjm-64	134	20	cells	cell	NOUN
bptjm-64	134	21	,	,	PUNCT
bptjm-64	134	22	including	include	VERB
bptjm-64	134	23	tumor	tumor	NOUN
bptjm-64	134	24	-	-	PUNCT
bptjm-64	134	25	associated	associate	VERB
bptjm-64	134	26	macrophages	macrophage	NOUN
bptjm-64	134	27	(	(	PUNCT
bptjm-64	134	28	tams	tam	NOUN
bptjm-64	134	29	)	)	PUNCT
bptjm-64	134	30	.	.	PUNCT
bptjm-64	135	1	blocking	block	VERB
bptjm-64	135	2	the	the	DET
bptjm-64	135	3	csf-1	csf-1	NOUN
bptjm-64	135	4	/	/	SYM
bptjm-64	135	5	r	r	NOUN
bptjm-64	135	6	pathway	pathway	NOUN
bptjm-64	135	7	promotes	promote	VERB
bptjm-64	135	8	the	the	DET
bptjm-64	135	9	tme	tme	NOUN
bptjm-64	135	10	by	by	ADP
bptjm-64	135	11	facilitating	facilitate	VERB
bptjm-64	135	12	the	the	DET
bptjm-64	135	13	in	in	ADP
bptjm-64	135	14	�	�	PROPN
bptjm-64	135	15	ltration	ltration	NOUN
bptjm-64	135	16	and	and	CCONJ
bptjm-64	135	17	reactivation	reactivation	NOUN
bptjm-64	135	18	of	of	ADP
bptjm-64	135	19	cytotoxic	cytotoxic	ADJ
bptjm-64	135	20	t	t	NOUN
bptjm-64	135	21	lymphocytes	lymphocyte	NOUN
bptjm-64	135	22	(	(	PUNCT
bptjm-64	135	23	ctls).32	ctls).32	X
bptjm-64	135	24	consequently	consequently	ADV
bptjm-64	135	25	,	,	PUNCT
bptjm-64	135	26	studying	study	VERB
bptjm-64	135	27	berkeley	berkeley	PROPN
bptjm-64	135	28	pharma	pharma	PROPN
bptjm-64	135	29	tech	tech	NOUN
bptjm-64	135	30	journal	journal	NOUN
bptjm-64	135	31	of	of	ADP
bptjm-64	135	32	medicine	medicine	NOUN
bptjm-64	135	33	|	|	ADV
bptjm-64	135	34	130	130	NUM
bptjm-64	135	35	various	various	ADJ
bptjm-64	135	36	signaling	signal	VERB
bptjm-64	135	37	pathways	pathway	NOUN
bptjm-64	135	38	can	can	AUX
bptjm-64	135	39	pave	pave	VERB
bptjm-64	135	40	the	the	DET
bptjm-64	135	41	way	way	NOUN
bptjm-64	135	42	for	for	ADP
bptjm-64	135	43	developing	develop	VERB
bptjm-64	135	44	nuanced	nuanced	ADJ
bptjm-64	135	45	cancer	cancer	NOUN
bptjm-64	135	46	immunotherapy	immunotherapy	NOUN
bptjm-64	135	47	treatments	treatment	NOUN
bptjm-64	135	48	.	.	PUNCT
bptjm-64	136	1	as	as	SCONJ
bptjm-64	136	2	discussed	discuss	VERB
bptjm-64	136	3	,	,	PUNCT
bptjm-64	136	4	the	the	DET
bptjm-64	136	5	tme	tme	NOUN
bptjm-64	136	6	consists	consist	VERB
bptjm-64	136	7	of	of	ADP
bptjm-64	136	8	various	various	ADJ
bptjm-64	136	9	components	component	NOUN
bptjm-64	136	10	,	,	PUNCT
bptjm-64	136	11	and	and	CCONJ
bptjm-64	136	12	understanding	understand	VERB
bptjm-64	136	13	these	these	DET
bptjm-64	136	14	di	di	NOUN
bptjm-64	136	15	�	�	PROPN
bptjm-64	136	16	erences	erence	NOUN
bptjm-64	136	17	in	in	ADP
bptjm-64	136	18	tme	tme	PROPN
bptjm-64	136	19	is	be	AUX
bptjm-64	136	20	crucial	crucial	ADJ
bptjm-64	136	21	for	for	ADP
bptjm-64	136	22	developing	develop	VERB
bptjm-64	136	23	e	e	NOUN
bptjm-64	136	24	�	�	NOUN
bptjm-64	136	25	ective	ective	ADJ
bptjm-64	136	26	treatments	treatment	NOUN
bptjm-64	136	27	and	and	CCONJ
bptjm-64	136	28	immunotherapy	immunotherapy	NOUN
bptjm-64	136	29	approaches	approach	NOUN
bptjm-64	136	30	for	for	ADP
bptjm-64	136	31	di	di	NOUN
bptjm-64	136	32	�	�	PROPN
bptjm-64	136	33	erent	erent	NOUN
bptjm-64	136	34	cancers	cancer	NOUN
bptjm-64	136	35	.	.	PUNCT
bptjm-64	137	1	identifying	identify	VERB
bptjm-64	137	2	and	and	CCONJ
bptjm-64	137	3	targeting	target	VERB
bptjm-64	137	4	the	the	DET
bptjm-64	137	5	most	most	ADV
bptjm-64	137	6	relevant	relevant	ADJ
bptjm-64	137	7	aspects	aspect	NOUN
bptjm-64	137	8	of	of	ADP
bptjm-64	137	9	the	the	DET
bptjm-64	137	10	tme	tme	NOUN
bptjm-64	137	11	for	for	ADP
bptjm-64	137	12	each	each	DET
bptjm-64	137	13	speci	speci	PROPN
bptjm-64	137	14	�	�	PROPN
bptjm-64	137	15	c	c	PROPN
bptjm-64	137	16	disease	disease	NOUN
bptjm-64	137	17	is	be	AUX
bptjm-64	137	18	key	key	ADJ
bptjm-64	137	19	to	to	ADP
bptjm-64	137	20	creating	create	VERB
bptjm-64	137	21	successful	successful	ADJ
bptjm-64	137	22	therapies	therapy	NOUN
bptjm-64	137	23	.	.	PUNCT
bptjm-64	138	1	5	5	X
bptjm-64	138	2	.	.	X
bptjm-64	138	3	non	non	ADJ
bptjm-64	138	4	-	-	ADJ
bptjm-64	138	5	small	small	ADJ
bptjm-64	138	6	cell	cell	NOUN
bptjm-64	138	7	lung	lung	NOUN
bptjm-64	138	8	cancer	cancer	NOUN
bptjm-64	138	9	non	non	ADJ
bptjm-64	138	10	-	-	ADJ
bptjm-64	138	11	small	small	ADJ
bptjm-64	138	12	cell	cell	NOUN
bptjm-64	138	13	lung	lung	NOUN
bptjm-64	138	14	cancer	cancer	NOUN
bptjm-64	138	15	(	(	PUNCT
bptjm-64	138	16	nsclc	nsclc	NOUN
bptjm-64	138	17	)	)	PUNCT
bptjm-64	138	18	is	be	AUX
bptjm-64	138	19	the	the	DET
bptjm-64	138	20	leading	lead	VERB
bptjm-64	138	21	cause	cause	NOUN
bptjm-64	138	22	of	of	ADP
bptjm-64	138	23	cancer	cancer	NOUN
bptjm-64	138	24	-	-	PUNCT
bptjm-64	138	25	related	relate	VERB
bptjm-64	138	26	death	death	NOUN
bptjm-64	138	27	and	and	CCONJ
bptjm-64	138	28	has	have	AUX
bptjm-64	138	29	become	become	VERB
bptjm-64	138	30	a	a	DET
bptjm-64	138	31	primary	primary	ADJ
bptjm-64	138	32	focus	focus	NOUN
bptjm-64	138	33	for	for	ADP
bptjm-64	138	34	the	the	DET
bptjm-64	138	35	development	development	NOUN
bptjm-64	138	36	of	of	ADP
bptjm-64	138	37	tme	tme	NOUN
bptjm-64	138	38	-	-	PUNCT
bptjm-64	138	39	based	base	VERB
bptjm-64	138	40	immunotherapy	immunotherapy	NOUN
bptjm-64	138	41	.	.	PUNCT
bptjm-64	139	1	similar	similar	ADJ
bptjm-64	139	2	to	to	ADP
bptjm-64	139	3	other	other	ADJ
bptjm-64	139	4	cancers	cancer	NOUN
bptjm-64	139	5	,	,	PUNCT
bptjm-64	139	6	nsclc	nsclc	NOUN
bptjm-64	139	7	features	feature	VERB
bptjm-64	139	8	an	an	DET
bptjm-64	139	9	immunosuppressive	immunosuppressive	ADJ
bptjm-64	139	10	tumor	tumor	NOUN
bptjm-64	139	11	microenvironment	microenvironment	NOUN
bptjm-64	139	12	(	(	PUNCT
bptjm-64	139	13	tme	tme	NOUN
bptjm-64	139	14	)	)	PUNCT
bptjm-64	139	15	and	and	CCONJ
bptjm-64	139	16	ctl	ctl	PROPN
bptjm-64	139	17	exhaustion	exhaustion	NOUN
bptjm-64	139	18	.	.	PUNCT
bptjm-64	140	1	however	however	ADV
bptjm-64	140	2	,	,	PUNCT
bptjm-64	140	3	it	it	PRON
bptjm-64	140	4	also	also	ADV
bptjm-64	140	5	has	have	VERB
bptjm-64	140	6	distinct	distinct	ADJ
bptjm-64	140	7	characteristics	characteristic	NOUN
bptjm-64	140	8	such	such	ADJ
bptjm-64	140	9	as	as	ADP
bptjm-64	140	10	variable	variable	ADJ
bptjm-64	140	11	blood	blood	NOUN
bptjm-64	140	12	�	�	PROPN
bptjm-64	140	13	ow	ow	PROPN
bptjm-64	140	14	,	,	PUNCT
bptjm-64	140	15	areas	area	NOUN
bptjm-64	140	16	of	of	ADP
bptjm-64	140	17	acidosis	acidosis	NOUN
bptjm-64	140	18	and	and	CCONJ
bptjm-64	140	19	hypoxia	hypoxia	NOUN
bptjm-64	140	20	,	,	PUNCT
bptjm-64	140	21	and	and	CCONJ
bptjm-64	140	22	increased	increase	VERB
bptjm-64	140	23	expression	expression	NOUN
bptjm-64	140	24	of	of	ADP
bptjm-64	140	25	hypoxia	hypoxia	NOUN
bptjm-64	140	26	markers	marker	NOUN
bptjm-64	140	27	.	.	PUNCT
bptjm-64	141	1	these	these	DET
bptjm-64	141	2	features	feature	NOUN
bptjm-64	141	3	can	can	AUX
bptjm-64	141	4	lead	lead	VERB
bptjm-64	141	5	to	to	ADP
bptjm-64	141	6	metastasis	metastasis	NOUN
bptjm-64	141	7	and	and	CCONJ
bptjm-64	141	8	elevated	elevated	ADJ
bptjm-64	141	9	resistance	resistance	NOUN
bptjm-64	141	10	to	to	ADP
bptjm-64	141	11	treatment.32,33	treatment.32,33	PROPN
bptjm-64	141	12	consequently	consequently	ADV
bptjm-64	141	13	,	,	PUNCT
bptjm-64	141	14	past	past	ADP
bptjm-64	141	15	therapies	therapy	NOUN
bptjm-64	141	16	targeting	target	VERB
bptjm-64	141	17	the	the	DET
bptjm-64	141	18	tme	tme	NOUN
bptjm-64	141	19	have	have	AUX
bptjm-64	141	20	focused	focus	VERB
bptjm-64	141	21	signi	signi	ADJ
bptjm-64	141	22	�	�	NOUN
bptjm-64	141	23	cantly	cantly	ADV
bptjm-64	141	24	on	on	ADP
bptjm-64	141	25	addressing	address	VERB
bptjm-64	141	26	hypoxia	hypoxia	NOUN
bptjm-64	141	27	and	and	CCONJ
bptjm-64	141	28	angiogenesis.33	angiogenesis.33	VERB
bptjm-64	141	29	a	a	DET
bptjm-64	141	30	recent	recent	ADJ
bptjm-64	141	31	study	study	NOUN
bptjm-64	141	32	conducted	conduct	VERB
bptjm-64	141	33	by	by	ADP
bptjm-64	141	34	zhao	zhao	PROPN
bptjm-64	141	35	et	et	PROPN
bptjm-64	141	36	al	al	PROPN
bptjm-64	141	37	.	.	PROPN
bptjm-64	141	38	adopts	adopt	VERB
bptjm-64	141	39	a	a	DET
bptjm-64	141	40	similar	similar	ADJ
bptjm-64	141	41	strategy	strategy	NOUN
bptjm-64	141	42	focusing	focus	VERB
bptjm-64	141	43	on	on	ADP
bptjm-64	141	44	the	the	DET
bptjm-64	141	45	tumor	tumor	NOUN
bptjm-64	141	46	microenvironment	microenvironment	NOUN
bptjm-64	141	47	(	(	PUNCT
bptjm-64	141	48	tme	tme	NOUN
bptjm-64	141	49	)	)	PUNCT
bptjm-64	141	50	.	.	PUNCT
bptjm-64	142	1	the	the	DET
bptjm-64	142	2	study	study	NOUN
bptjm-64	142	3	delves	delve	VERB
bptjm-64	142	4	into	into	ADP
bptjm-64	142	5	a	a	DET
bptjm-64	142	6	phase	phase	NOUN
bptjm-64	142	7	iii	iii	NOUN
bptjm-64	142	8	trial	trial	NOUN
bptjm-64	142	9	combining	combine	VERB
bptjm-64	142	10	bevacizumab	bevacizumab	NOUN
bptjm-64	142	11	,	,	PUNCT
bptjm-64	142	12	atezolizumab	atezolizumab	NOUN
bptjm-64	142	13	,	,	PUNCT
bptjm-64	142	14	and	and	CCONJ
bptjm-64	142	15	chemotherapy	chemotherapy	NOUN
bptjm-64	142	16	for	for	ADP
bptjm-64	142	17	metastatic	metastatic	ADJ
bptjm-64	142	18	non	non	ADJ
bptjm-64	142	19	-	-	ADJ
bptjm-64	142	20	squamous	squamous	ADJ
bptjm-64	142	21	non	non	ADJ
bptjm-64	142	22	-	-	ADJ
bptjm-64	142	23	small	small	ADJ
bptjm-64	142	24	cell	cell	NOUN
bptjm-64	142	25	lung	lung	NOUN
bptjm-64	142	26	cancer	cancer	NOUN
bptjm-64	142	27	(	(	PUNCT
bptjm-64	142	28	nsclc	nsclc	NOUN
bptjm-64	142	29	)	)	PUNCT
bptjm-64	142	30	.	.	PUNCT
bptjm-64	143	1	bevacizumab	bevacizumab	PROPN
bptjm-64	143	2	,	,	PUNCT
bptjm-64	143	3	an	an	DET
bptjm-64	143	4	igg	igg	NOUN
bptjm-64	143	5	antibody	antibody	NOUN
bptjm-64	143	6	that	that	PRON
bptjm-64	143	7	obstructs	obstruct	VERB
bptjm-64	143	8	the	the	DET
bptjm-64	143	9	vascular	vascular	ADJ
bptjm-64	143	10	endothelial	endothelial	ADJ
bptjm-64	143	11	growth	growth	NOUN
bptjm-64	143	12	factor	factor	NOUN
bptjm-64	143	13	(	(	PUNCT
bptjm-64	143	14	vegf	vegf	PROPN
bptjm-64	143	15	)	)	PUNCT
bptjm-64	143	16	pathway	pathway	NOUN
bptjm-64	143	17	by	by	ADP
bptjm-64	143	18	binding	bind	VERB
bptjm-64	143	19	to	to	ADP
bptjm-64	143	20	vegf	vegf	PROPN
bptjm-64	143	21	-	-	PUNCT
bptjm-64	143	22	a	a	PROPN
bptjm-64	143	23	,	,	PUNCT
bptjm-64	143	24	has	have	AUX
bptjm-64	143	25	demonstrated	demonstrate	VERB
bptjm-64	143	26	e	e	PROPN
bptjm-64	143	27	�	�	NOUN
bptjm-64	143	28	cacy	cacy	NOUN
bptjm-64	143	29	in	in	ADP
bptjm-64	143	30	treating	treat	VERB
bptjm-64	143	31	nsclc	nsclc	NOUN
bptjm-64	143	32	.	.	PUNCT
bptjm-64	144	1	the	the	DET
bptjm-64	144	2	vegf	vegf	PROPN
bptjm-64	144	3	pathway	pathway	NOUN
bptjm-64	144	4	is	be	AUX
bptjm-64	144	5	a	a	DET
bptjm-64	144	6	prime	prime	ADJ
bptjm-64	144	7	target	target	NOUN
bptjm-64	144	8	due	due	ADP
bptjm-64	144	9	to	to	ADP
bptjm-64	144	10	its	its	PRON
bptjm-64	144	11	overexpression	overexpression	NOUN
bptjm-64	144	12	in	in	ADP
bptjm-64	144	13	nsclc	nsclc	NOUN
bptjm-64	144	14	,	,	PUNCT
bptjm-64	144	15	correlating	correlate	VERB
bptjm-64	144	16	with	with	ADP
bptjm-64	144	17	tumor	tumor	NOUN
bptjm-64	144	18	recurrence	recurrence	NOUN
bptjm-64	144	19	,	,	PUNCT
bptjm-64	144	20	low	low	ADJ
bptjm-64	144	21	survival	survival	NOUN
bptjm-64	144	22	rates	rate	NOUN
bptjm-64	144	23	,	,	PUNCT
bptjm-64	144	24	metastasis	metastasis	NOUN
bptjm-64	144	25	,	,	PUNCT
bptjm-64	144	26	and	and	CCONJ
bptjm-64	144	27	mortality	mortality	NOUN
bptjm-64	144	28	.	.	PUNCT
bptjm-64	145	1	a	a	DET
bptjm-64	145	2	recent	recent	ADJ
bptjm-64	145	3	study	study	NOUN
bptjm-64	145	4	conducted	conduct	VERB
bptjm-64	145	5	by	by	ADP
bptjm-64	145	6	zhao	zhao	PROPN
bptjm-64	145	7	et	et	PROPN
bptjm-64	145	8	al	al	PROPN
bptjm-64	145	9	.	.	PROPN
bptjm-64	145	10	adopts	adopt	VERB
bptjm-64	145	11	a	a	DET
bptjm-64	145	12	similar	similar	ADJ
bptjm-64	145	13	strategy	strategy	NOUN
bptjm-64	145	14	focusing	focus	VERB
bptjm-64	145	15	on	on	ADP
bptjm-64	145	16	the	the	DET
bptjm-64	145	17	tumor	tumor	NOUN
bptjm-64	145	18	microenvironment	microenvironment	NOUN
bptjm-64	145	19	(	(	PUNCT
bptjm-64	145	20	tme	tme	NOUN
bptjm-64	145	21	)	)	PUNCT
bptjm-64	145	22	.	.	PUNCT
bptjm-64	146	1	the	the	DET
bptjm-64	146	2	study	study	NOUN
bptjm-64	146	3	delves	delve	VERB
bptjm-64	146	4	into	into	ADP
bptjm-64	146	5	a	a	DET
bptjm-64	146	6	phase	phase	NOUN
bptjm-64	146	7	iii	iii	NOUN
bptjm-64	146	8	trial	trial	NOUN
bptjm-64	146	9	combining	combine	VERB
bptjm-64	146	10	bevacizumab	bevacizumab	NOUN
bptjm-64	146	11	,	,	PUNCT
bptjm-64	146	12	atezolizumab	atezolizumab	NOUN
bptjm-64	146	13	,	,	PUNCT
bptjm-64	146	14	and	and	CCONJ
bptjm-64	146	15	chemotherapy	chemotherapy	NOUN
bptjm-64	146	16	for	for	ADP
bptjm-64	146	17	metastatic	metastatic	ADJ
bptjm-64	146	18	non	non	ADJ
bptjm-64	146	19	-	-	ADJ
bptjm-64	146	20	squamous	squamous	ADJ
bptjm-64	146	21	non	non	ADJ
bptjm-64	146	22	-	-	ADJ
bptjm-64	146	23	small	small	ADJ
bptjm-64	146	24	cell	cell	NOUN
bptjm-64	146	25	lung	lung	NOUN
bptjm-64	146	26	cancer	cancer	NOUN
bptjm-64	146	27	(	(	PUNCT
bptjm-64	146	28	nsclc	nsclc	NOUN
bptjm-64	146	29	)	)	PUNCT
bptjm-64	146	30	.	.	PUNCT
bptjm-64	147	1	berkeley	berkeley	PROPN
bptjm-64	147	2	pharma	pharma	PROPN
bptjm-64	147	3	tech	tech	PROPN
bptjm-64	147	4	journal	journal	NOUN
bptjm-64	147	5	of	of	ADP
bptjm-64	147	6	medicine	medicine	NOUN
bptjm-64	147	7	|	|	ADV
bptjm-64	147	8	131	131	NUM
bptjm-64	147	9	bevacizumab	bevacizumab	NOUN
bptjm-64	147	10	,	,	PUNCT
bptjm-64	147	11	an	an	DET
bptjm-64	147	12	igg	igg	NOUN
bptjm-64	147	13	antibody	antibody	NOUN
bptjm-64	147	14	that	that	PRON
bptjm-64	147	15	obstructs	obstruct	VERB
bptjm-64	147	16	the	the	DET
bptjm-64	147	17	vascular	vascular	ADJ
bptjm-64	147	18	endothelial	endothelial	ADJ
bptjm-64	147	19	growth	growth	NOUN
bptjm-64	147	20	factor	factor	NOUN
bptjm-64	147	21	(	(	PUNCT
bptjm-64	147	22	vegf	vegf	PROPN
bptjm-64	147	23	)	)	PUNCT
bptjm-64	147	24	pathway	pathway	NOUN
bptjm-64	147	25	by	by	ADP
bptjm-64	147	26	binding	bind	VERB
bptjm-64	147	27	to	to	ADP
bptjm-64	147	28	vegf	vegf	PROPN
bptjm-64	147	29	-	-	PUNCT
bptjm-64	147	30	a	a	PROPN
bptjm-64	147	31	,	,	PUNCT
bptjm-64	147	32	has	have	AUX
bptjm-64	147	33	demonstrated	demonstrate	VERB
bptjm-64	147	34	e	e	PROPN
bptjm-64	147	35	�	�	NOUN
bptjm-64	147	36	cacy	cacy	NOUN
bptjm-64	147	37	in	in	ADP
bptjm-64	147	38	treating	treat	VERB
bptjm-64	147	39	nsclc.19	nsclc.19	PROPN
bptjm-64	147	40	the	the	DET
bptjm-64	147	41	vegf	vegf	PROPN
bptjm-64	147	42	pathway	pathway	NOUN
bptjm-64	147	43	is	be	AUX
bptjm-64	147	44	a	a	DET
bptjm-64	147	45	prime	prime	ADJ
bptjm-64	147	46	target	target	NOUN
bptjm-64	147	47	due	due	ADP
bptjm-64	147	48	to	to	ADP
bptjm-64	147	49	its	its	PRON
bptjm-64	147	50	overexpression	overexpression	NOUN
bptjm-64	147	51	in	in	ADP
bptjm-64	147	52	nsclc	nsclc	NOUN
bptjm-64	147	53	,	,	PUNCT
bptjm-64	147	54	correlating	correlate	VERB
bptjm-64	147	55	with	with	ADP
bptjm-64	147	56	tumor	tumor	NOUN
bptjm-64	147	57	recurrence	recurrence	NOUN
bptjm-64	147	58	,	,	PUNCT
bptjm-64	147	59	low	low	ADJ
bptjm-64	147	60	survival	survival	NOUN
bptjm-64	147	61	rates	rate	NOUN
bptjm-64	147	62	,	,	PUNCT
bptjm-64	147	63	metastasis	metastasis	NOUN
bptjm-64	147	64	,	,	PUNCT
bptjm-64	147	65	and	and	CCONJ
bptjm-64	147	66	mortality.19	mortality.19	NOUN
bptjm-64	147	67	apart	apart	ADV
bptjm-64	147	68	from	from	ADP
bptjm-64	147	69	bevacizumab	bevacizumab	PROPN
bptjm-64	147	70	,	,	PUNCT
bptjm-64	147	71	other	other	ADJ
bptjm-64	147	72	antibodies	antibody	NOUN
bptjm-64	147	73	like	like	ADP
bptjm-64	147	74	ramucirumab	ramucirumab	NOUN
bptjm-64	147	75	and	and	CCONJ
bptjm-64	147	76	nintedanib	nintedanib	NOUN
bptjm-64	147	77	have	have	AUX
bptjm-64	147	78	demonstrated	demonstrate	VERB
bptjm-64	147	79	enhancements	enhancement	NOUN
bptjm-64	147	80	in	in	ADP
bptjm-64	147	81	overall	overall	ADJ
bptjm-64	147	82	survival	survival	NOUN
bptjm-64	147	83	(	(	PUNCT
bptjm-64	147	84	os	os	NOUN
bptjm-64	147	85	)	)	PUNCT
bptjm-64	147	86	,	,	PUNCT
bptjm-64	147	87	along	along	ADP
bptjm-64	147	88	with	with	ADP
bptjm-64	147	89	tyrosine	tyrosine	PROPN
bptjm-64	147	90	kinase	kinase	PROPN
bptjm-64	147	91	inhibitors	inhibitor	NOUN
bptjm-64	147	92	(	(	PUNCT
bptjm-64	147	93	tkis	tkis	NOUN
bptjm-64	147	94	)	)	PUNCT
bptjm-64	147	95	capable	capable	ADJ
bptjm-64	147	96	of	of	ADP
bptjm-64	147	97	inhibiting	inhibit	VERB
bptjm-64	147	98	the	the	DET
bptjm-64	147	99	vascular	vascular	ADJ
bptjm-64	147	100	endothelial	endothelial	ADJ
bptjm-64	147	101	growth	growth	NOUN
bptjm-64	147	102	factor	factor	NOUN
bptjm-64	147	103	(	(	PUNCT
bptjm-64	147	104	vegf	vegf	PROPN
bptjm-64	147	105	)	)	PUNCT
bptjm-64	147	106	pathway.19	pathway.19	PROPN
bptjm-64	147	107	however	however	ADV
bptjm-64	147	108	,	,	PUNCT
bptjm-64	147	109	the	the	DET
bptjm-64	147	110	vegf	vegf	PROPN
bptjm-64	147	111	pathway	pathway	NOUN
bptjm-64	147	112	primarily	primarily	ADV
bptjm-64	147	113	addresses	address	VERB
bptjm-64	147	114	the	the	DET
bptjm-64	147	115	angiogenic	angiogenic	ADJ
bptjm-64	147	116	aspect	aspect	NOUN
bptjm-64	147	117	of	of	ADP
bptjm-64	147	118	tumors	tumor	NOUN
bptjm-64	147	119	,	,	PUNCT
bptjm-64	147	120	prompting	prompt	VERB
bptjm-64	147	121	its	its	PRON
bptjm-64	147	122	utilization	utilization	NOUN
bptjm-64	147	123	in	in	ADP
bptjm-64	147	124	combination	combination	NOUN
bptjm-64	147	125	therapies	therapy	NOUN
bptjm-64	147	126	with	with	ADP
bptjm-64	147	127	chemotherapy	chemotherapy	NOUN
bptjm-64	147	128	and	and	CCONJ
bptjm-64	147	129	immunotherapy	immunotherapy	NOUN
bptjm-64	147	130	,	,	PUNCT
bptjm-64	147	131	which	which	PRON
bptjm-64	147	132	have	have	AUX
bptjm-64	147	133	proven	prove	VERB
bptjm-64	147	134	e	e	NOUN
bptjm-64	147	135	�	�	NOUN
bptjm-64	147	136	ective	ective	ADJ
bptjm-64	147	137	.	.	PUNCT
bptjm-64	148	1	in	in	ADP
bptjm-64	148	2	a	a	DET
bptjm-64	148	3	similar	similar	ADJ
bptjm-64	148	4	vein	vein	NOUN
bptjm-64	148	5	,	,	PUNCT
bptjm-64	148	6	this	this	DET
bptjm-64	148	7	phase	phase	NOUN
bptjm-64	148	8	iii	iii	NUM
bptjm-64	148	9	trial	trial	NOUN
bptjm-64	148	10	combines	combine	VERB
bptjm-64	148	11	bevacizumab	bevacizumab	NOUN
bptjm-64	148	12	with	with	ADP
bptjm-64	148	13	atezolizumab	atezolizumab	NOUN
bptjm-64	148	14	,	,	PUNCT
bptjm-64	148	15	an	an	DET
bptjm-64	148	16	immune	immune	ADJ
bptjm-64	148	17	checkpoint	checkpoint	NOUN
bptjm-64	148	18	inhibitor	inhibitor	NOUN
bptjm-64	148	19	targeting	target	VERB
bptjm-64	148	20	the	the	DET
bptjm-64	148	21	pd	pd	PROPN
bptjm-64	148	22	-	-	PUNCT
bptjm-64	148	23	l1	l1	PROPN
bptjm-64	148	24	ligand	ligand	NOUN
bptjm-64	148	25	(	(	PUNCT
bptjm-64	148	26	anti	anti	ADJ
bptjm-64	148	27	-	-	ADJ
bptjm-64	148	28	pd-1	pd-1	ADJ
bptjm-64	148	29	)	)	PUNCT
bptjm-64	148	30	,	,	PUNCT
bptjm-64	148	31	alongside	alongside	ADP
bptjm-64	148	32	chemotherapy	chemotherapy	NOUN
bptjm-64	148	33	.	.	PUNCT
bptjm-64	149	1	this	this	DET
bptjm-64	149	2	multifaceted	multifaceted	ADJ
bptjm-64	149	3	therapeutic	therapeutic	ADJ
bptjm-64	149	4	approach	approach	NOUN
bptjm-64	149	5	to	to	ADP
bptjm-64	149	6	non	non	ADJ
bptjm-64	149	7	-	-	ADJ
bptjm-64	149	8	small	small	ADJ
bptjm-64	149	9	cell	cell	NOUN
bptjm-64	149	10	lung	lung	NOUN
bptjm-64	149	11	cancer	cancer	NOUN
bptjm-64	149	12	(	(	PUNCT
bptjm-64	149	13	nsclc	nsclc	NOUN
bptjm-64	149	14	)	)	PUNCT
bptjm-64	149	15	aims	aim	VERB
bptjm-64	149	16	to	to	PART
bptjm-64	149	17	enhance	enhance	VERB
bptjm-64	149	18	progression	progression	NOUN
bptjm-64	149	19	-	-	PUNCT
bptjm-64	149	20	free	free	ADJ
bptjm-64	149	21	survival	survival	NOUN
bptjm-64	149	22	and	and	CCONJ
bptjm-64	149	23	os.32	os.32	VERB
bptjm-64	149	24	5.1	5.1	NUM
bptjm-64	149	25	nsclc	nsclc	NOUN
bptjm-64	149	26	combination	combination	NOUN
bptjm-64	149	27	therapy	therapy	NOUN
bptjm-64	149	28	the	the	DET
bptjm-64	149	29	primary	primary	ADJ
bptjm-64	149	30	treatment	treatment	NOUN
bptjm-64	149	31	modality	modality	NOUN
bptjm-64	149	32	for	for	ADP
bptjm-64	149	33	non	non	ADJ
bptjm-64	149	34	-	-	ADJ
bptjm-64	149	35	small	small	ADJ
bptjm-64	149	36	cell	cell	NOUN
bptjm-64	149	37	lung	lung	NOUN
bptjm-64	149	38	cancer	cancer	NOUN
bptjm-64	149	39	(	(	PUNCT
bptjm-64	149	40	nsclc	nsclc	NOUN
bptjm-64	149	41	)	)	PUNCT
bptjm-64	149	42	typically	typically	ADV
bptjm-64	149	43	involves	involve	VERB
bptjm-64	149	44	immune	immune	ADJ
bptjm-64	149	45	checkpoint	checkpoint	NOUN
bptjm-64	149	46	inhibitors	inhibitor	NOUN
bptjm-64	149	47	(	(	PUNCT
bptjm-64	149	48	icis	icis	NOUN
bptjm-64	149	49	)	)	PUNCT
bptjm-64	149	50	like	like	ADP
bptjm-64	149	51	pembrolizumab	pembrolizumab	NOUN
bptjm-64	149	52	,	,	PUNCT
bptjm-64	149	53	an	an	DET
bptjm-64	149	54	anti	anti	ADJ
bptjm-64	149	55	-	-	ADJ
bptjm-64	149	56	pd-1	pd-1	ADJ
bptjm-64	149	57	antibody	antibody	NOUN
bptjm-64	149	58	.	.	PUNCT
bptjm-64	150	1	pembrolizumab	pembrolizumab	NOUN
bptjm-64	150	2	has	have	AUX
bptjm-64	150	3	emerged	emerge	VERB
bptjm-64	150	4	as	as	ADP
bptjm-64	150	5	the	the	DET
bptjm-64	150	6	�	�	PROPN
bptjm-64	150	7	rst	rst	ADJ
bptjm-64	150	8	-	-	PUNCT
bptjm-64	150	9	line	line	NOUN
bptjm-64	150	10	treatment	treatment	NOUN
bptjm-64	150	11	for	for	ADP
bptjm-64	150	12	metastatic	metastatic	ADJ
bptjm-64	150	13	nsclc	nsclc	NOUN
bptjm-64	150	14	due	due	ADP
bptjm-64	150	15	to	to	ADP
bptjm-64	150	16	its	its	PRON
bptjm-64	150	17	notable	notable	ADJ
bptjm-64	150	18	response	response	NOUN
bptjm-64	150	19	rates	rate	NOUN
bptjm-64	150	20	and	and	CCONJ
bptjm-64	150	21	sustained	sustain	VERB
bptjm-64	150	22	tumor	tumor	NOUN
bptjm-64	150	23	regression.14	regression.14	PROPN
bptjm-64	150	24	however	however	ADV
bptjm-64	150	25	,	,	PUNCT
bptjm-64	150	26	despite	despite	SCONJ
bptjm-64	150	27	its	its	PRON
bptjm-64	150	28	e	e	PROPN
bptjm-64	150	29	�	�	NOUN
bptjm-64	150	30	cacy	cacy	NOUN
bptjm-64	150	31	,	,	PUNCT
bptjm-64	150	32	many	many	ADJ
bptjm-64	150	33	patients	patient	NOUN
bptjm-64	150	34	encounter	encounter	VERB
bptjm-64	150	35	resistance	resistance	NOUN
bptjm-64	150	36	to	to	ADP
bptjm-64	150	37	these	these	DET
bptjm-64	150	38	treatments	treatment	NOUN
bptjm-64	150	39	or	or	CCONJ
bptjm-64	150	40	su	su	PROPN
bptjm-64	150	41	�	�	PROPN
bptjm-64	150	42	er	er	NOUN
bptjm-64	150	43	from	from	ADP
bptjm-64	150	44	immune	immune	NOUN
bptjm-64	150	45	-	-	PUNCT
bptjm-64	150	46	related	relate	VERB
bptjm-64	150	47	adverse	adverse	ADJ
bptjm-64	150	48	events.14	events.14	NOUN
bptjm-64	150	49	consequently	consequently	ADV
bptjm-64	150	50	,	,	PUNCT
bptjm-64	150	51	combination	combination	NOUN
bptjm-64	150	52	therapy	therapy	NOUN
bptjm-64	150	53	has	have	AUX
bptjm-64	150	54	emerged	emerge	VERB
bptjm-64	150	55	as	as	ADP
bptjm-64	150	56	a	a	DET
bptjm-64	150	57	pivotal	pivotal	ADJ
bptjm-64	150	58	focus	focus	NOUN
bptjm-64	150	59	for	for	ADP
bptjm-64	150	60	advancing	advance	VERB
bptjm-64	150	61	cancer	cancer	NOUN
bptjm-64	150	62	treatments	treatment	NOUN
bptjm-64	150	63	.	.	PUNCT
bptjm-64	151	1	a	a	DET
bptjm-64	151	2	recent	recent	ADJ
bptjm-64	151	3	study	study	NOUN
bptjm-64	151	4	conducted	conduct	VERB
bptjm-64	151	5	in	in	ADP
bptjm-64	151	6	2022	2022	NUM
bptjm-64	151	7	by	by	ADP
bptjm-64	151	8	reckamp	reckamp	PROPN
bptjm-64	151	9	et	et	PROPN
bptjm-64	151	10	al	al	PROPN
bptjm-64	151	11	.	.	PROPN
bptjm-64	151	12	explored	explore	VERB
bptjm-64	151	13	combination	combination	NOUN
bptjm-64	151	14	therapy	therapy	NOUN
bptjm-64	151	15	involving	involve	VERB
bptjm-64	151	16	icis	icis	NOUN
bptjm-64	151	17	and	and	CCONJ
bptjm-64	151	18	vascular	vascular	VERB
bptjm-64	151	19	endothelial	endothelial	ADJ
bptjm-64	151	20	growth	growth	NOUN
bptjm-64	151	21	factor	factor	NOUN
bptjm-64	151	22	(	(	PUNCT
bptjm-64	151	23	vegf	vegf	NOUN
bptjm-64	151	24	)	)	PUNCT
bptjm-64	151	25	receptor	receptor	NOUN
bptjm-64	151	26	inhibition	inhibition	NOUN
bptjm-64	151	27	in	in	ADP
bptjm-64	151	28	nsclc	nsclc	NOUN
bptjm-64	151	29	patients	patient	NOUN
bptjm-64	151	30	.	.	PUNCT
bptjm-64	152	1	patients	patient	NOUN
bptjm-64	152	2	were	be	AUX
bptjm-64	152	3	administered	administer	VERB
bptjm-64	152	4	a	a	DET
bptjm-64	152	5	combination	combination	NOUN
bptjm-64	152	6	of	of	ADP
bptjm-64	152	7	either	either	DET
bptjm-64	152	8	ramucirumab	ramucirumab	NOUN
bptjm-64	152	9	(	(	PUNCT
bptjm-64	152	10	vegf	vegf	NOUN
bptjm-64	152	11	inhibitor	inhibitor	PROPN
bptjm-64	152	12	)	)	PUNCT
bptjm-64	152	13	and	and	CCONJ
bptjm-64	152	14	pembrolizumab	pembrolizumab	NOUN
bptjm-64	152	15	(	(	PUNCT
bptjm-64	152	16	ici	ici	PROPN
bptjm-64	152	17	)	)	PUNCT
bptjm-64	152	18	,	,	PUNCT
bptjm-64	152	19	or	or	CCONJ
bptjm-64	152	20	the	the	DET
bptjm-64	152	21	investigator	investigator	NOUN
bptjm-64	152	22	’s	’s	PART
bptjm-64	152	23	standard	standard	NOUN
bptjm-64	152	24	of	of	ADP
bptjm-64	152	25	care	care	NOUN
bptjm-64	152	26	,	,	PUNCT
bptjm-64	152	27	such	such	ADJ
bptjm-64	152	28	as	as	ADP
bptjm-64	152	29	docetaxel	docetaxel	NOUN
bptjm-64	152	30	,	,	PUNCT
bptjm-64	152	31	gemcitabine	gemcitabine	NOUN
bptjm-64	152	32	,	,	PUNCT
bptjm-64	152	33	or	or	CCONJ
bptjm-64	152	34	pemetrexed.34	pemetrexed.34	NOUN
bptjm-64	152	35	among	among	ADP
bptjm-64	152	36	the	the	DET
bptjm-64	152	37	136	136	NUM
bptjm-64	152	38	eligible	eligible	ADJ
bptjm-64	152	39	patients	patient	NOUN
bptjm-64	152	40	,	,	PUNCT
bptjm-64	152	41	those	those	PRON
bptjm-64	152	42	who	who	PRON
bptjm-64	152	43	received	receive	VERB
bptjm-64	152	44	ramucirumab	ramucirumab	NOUN
bptjm-64	152	45	and	and	CCONJ
bptjm-64	152	46	pembrolizumab	pembrolizumab	NOUN
bptjm-64	152	47	exhibited	exhibit	VERB
bptjm-64	152	48	signi	signi	PROPN
bptjm-64	152	49	�	�	PROPN
bptjm-64	152	50	cantly	cantly	ADV
bptjm-64	152	51	higher	high	ADJ
bptjm-64	152	52	overall	overall	ADJ
bptjm-64	152	53	berkeley	berkeley	PROPN
bptjm-64	152	54	pharma	pharma	PROPN
bptjm-64	152	55	tech	tech	NOUN
bptjm-64	152	56	journal	journal	NOUN
bptjm-64	152	57	of	of	ADP
bptjm-64	152	58	medicine	medicine	NOUN
bptjm-64	152	59	|	|	ADV
bptjm-64	152	60	132	132	NUM
bptjm-64	152	61	survival	survival	NOUN
bptjm-64	152	62	(	(	PUNCT
bptjm-64	152	63	os	os	NOUN
bptjm-64	152	64	)	)	PUNCT
bptjm-64	152	65	,	,	PUNCT
bptjm-64	152	66	suggesting	suggest	VERB
bptjm-64	152	67	another	another	DET
bptjm-64	152	68	promising	promising	ADJ
bptjm-64	152	69	combination	combination	NOUN
bptjm-64	152	70	therapy	therapy	NOUN
bptjm-64	152	71	avenue	avenue	NOUN
bptjm-64	152	72	for	for	ADP
bptjm-64	152	73	treating	treat	VERB
bptjm-64	152	74	nsclc.34	nsclc.34	ADV
bptjm-64	152	75	in	in	ADP
bptjm-64	152	76	september	september	PROPN
bptjm-64	152	77	2022	2022	NUM
bptjm-64	152	78	,	,	PUNCT
bptjm-64	152	79	casarrubios	casarrubio	NOUN
bptjm-64	152	80	et	et	PROPN
bptjm-64	152	81	al	al	PROPN
bptjm-64	152	82	.	.	PROPN
bptjm-64	152	83	conducted	conduct	VERB
bptjm-64	152	84	a	a	DET
bptjm-64	152	85	study	study	NOUN
bptjm-64	152	86	focusing	focus	VERB
bptjm-64	152	87	on	on	ADP
bptjm-64	152	88	a	a	DET
bptjm-64	152	89	speci	speci	ADJ
bptjm-64	152	90	�	�	PROPN
bptjm-64	152	91	c	c	NOUN
bptjm-64	152	92	form	form	NOUN
bptjm-64	152	93	of	of	ADP
bptjm-64	152	94	combination	combination	NOUN
bptjm-64	152	95	therapy	therapy	NOUN
bptjm-64	152	96	called	call	VERB
bptjm-64	152	97	neoadjuvant	neoadjuvant	ADJ
bptjm-64	152	98	chemoimmunotherapy	chemoimmunotherapy	NOUN
bptjm-64	152	99	.	.	PUNCT
bptjm-64	153	1	this	this	DET
bptjm-64	153	2	approach	approach	NOUN
bptjm-64	153	3	utilizes	utilize	VERB
bptjm-64	153	4	both	both	DET
bptjm-64	153	5	chemotherapy	chemotherapy	NOUN
bptjm-64	153	6	and	and	CCONJ
bptjm-64	153	7	immunotherapy	immunotherapy	NOUN
bptjm-64	153	8	to	to	PART
bptjm-64	153	9	reduce	reduce	VERB
bptjm-64	153	10	tumor	tumor	NOUN
bptjm-64	153	11	size	size	NOUN
bptjm-64	153	12	before	before	ADP
bptjm-64	153	13	more	more	ADV
bptjm-64	153	14	targeted	target	VERB
bptjm-64	153	15	treatment	treatment	NOUN
bptjm-64	153	16	aimed	aim	VERB
bptjm-64	153	17	at	at	ADP
bptjm-64	153	18	tumor	tumor	NOUN
bptjm-64	153	19	removal	removal	NOUN
bptjm-64	153	20	.	.	PUNCT
bptjm-64	154	1	through	through	ADP
bptjm-64	154	2	bulk	bulk	ADJ
bptjm-64	154	3	rna	rna	NOUN
bptjm-64	154	4	sequencing	sequencing	NOUN
bptjm-64	154	5	,	,	PUNCT
bptjm-64	154	6	the	the	DET
bptjm-64	154	7	researchers	researcher	NOUN
bptjm-64	154	8	analyzed	analyze	VERB
bptjm-64	154	9	samples	sample	NOUN
bptjm-64	154	10	from	from	ADP
bptjm-64	154	11	41	41	NUM
bptjm-64	154	12	patients	patient	NOUN
bptjm-64	154	13	with	with	ADP
bptjm-64	154	14	stage	stage	NOUN
bptjm-64	154	15	iii	iii	NUM
bptjm-64	154	16	non	non	ADJ
bptjm-64	154	17	-	-	ADJ
bptjm-64	154	18	small	small	ADJ
bptjm-64	154	19	cell	cell	NOUN
bptjm-64	154	20	lung	lung	NOUN
bptjm-64	154	21	cancer	cancer	NOUN
bptjm-64	154	22	(	(	PUNCT
bptjm-64	154	23	nsclc	nsclc	NOUN
bptjm-64	154	24	)	)	PUNCT
bptjm-64	154	25	who	who	PRON
bptjm-64	154	26	underwent	undergo	VERB
bptjm-64	154	27	three	three	NUM
bptjm-64	154	28	cycles	cycle	NOUN
bptjm-64	154	29	of	of	ADP
bptjm-64	154	30	nivolumab	nivolumab	NOUN
bptjm-64	154	31	(	(	PUNCT
bptjm-64	154	32	an	an	DET
bptjm-64	154	33	anti	anti	ADJ
bptjm-64	154	34	-	-	ADJ
bptjm-64	154	35	pd-1	pd-1	ADJ
bptjm-64	154	36	drug	drug	NOUN
bptjm-64	154	37	)	)	PUNCT
bptjm-64	154	38	and	and	CCONJ
bptjm-64	154	39	chemotherapy	chemotherapy	NOUN
bptjm-64	154	40	.	.	PUNCT
bptjm-64	155	1	their	their	PRON
bptjm-64	155	2	�	�	NOUN
bptjm-64	155	3	ndings	nding	NOUN
bptjm-64	155	4	revealed	reveal	VERB
bptjm-64	155	5	downregulation	downregulation	NOUN
bptjm-64	155	6	of	of	ADP
bptjm-64	155	7	tumor	tumor	NOUN
bptjm-64	155	8	and	and	CCONJ
bptjm-64	155	9	proliferation	proliferation	NOUN
bptjm-64	155	10	markers	marker	NOUN
bptjm-64	155	11	,	,	PUNCT
bptjm-64	155	12	along	along	ADP
bptjm-64	155	13	with	with	ADP
bptjm-64	155	14	genes	gene	NOUN
bptjm-64	155	15	associated	associate	VERB
bptjm-64	155	16	with	with	ADP
bptjm-64	155	17	ifnγ	ifnγ	NOUN
bptjm-64	155	18	signaling.35	signaling.35	NOUN
bptjm-64	155	19	additionally	additionally	ADV
bptjm-64	155	20	,	,	PUNCT
bptjm-64	155	21	they	they	PRON
bptjm-64	155	22	observed	observe	VERB
bptjm-64	155	23	the	the	DET
bptjm-64	155	24	regulation	regulation	NOUN
bptjm-64	155	25	of	of	ADP
bptjm-64	155	26	numerous	numerous	ADJ
bptjm-64	155	27	genes	gene	NOUN
bptjm-64	155	28	such	such	ADJ
bptjm-64	155	29	as	as	ADP
bptjm-64	155	30	ifng	ifng	NOUN
bptjm-64	155	31	and	and	CCONJ
bptjm-64	155	32	nkg7	nkg7	NOUN
bptjm-64	155	33	,	,	PUNCT
bptjm-64	155	34	distinguishing	distinguish	VERB
bptjm-64	155	35	between	between	ADP
bptjm-64	155	36	complete	complete	ADJ
bptjm-64	155	37	pathological	pathological	ADJ
bptjm-64	155	38	response	response	NOUN
bptjm-64	155	39	(	(	PUNCT
bptjm-64	155	40	cpr	cpr	PROPN
bptjm-64	155	41	)	)	PUNCT
bptjm-64	155	42	and	and	CCONJ
bptjm-64	155	43	non	non	ADJ
bptjm-64	155	44	-	-	ADJ
bptjm-64	155	45	cpr	cpr	ADJ
bptjm-64	155	46	tumors	tumor	NOUN
bptjm-64	155	47	before	before	ADP
bptjm-64	155	48	and	and	CCONJ
bptjm-64	155	49	after	after	ADP
bptjm-64	155	50	treatment	treatment	NOUN
bptjm-64	155	51	.	.	PUNCT
bptjm-64	156	1	this	this	DET
bptjm-64	156	2	study	study	NOUN
bptjm-64	156	3	lays	lay	VERB
bptjm-64	156	4	the	the	DET
bptjm-64	156	5	groundwork	groundwork	NOUN
bptjm-64	156	6	for	for	ADP
bptjm-64	156	7	future	future	ADJ
bptjm-64	156	8	personalized	personalized	ADJ
bptjm-64	156	9	immunotherapy	immunotherapy	NOUN
bptjm-64	156	10	approaches	approach	NOUN
bptjm-64	156	11	based	base	VERB
bptjm-64	156	12	on	on	ADP
bptjm-64	156	13	predictive	predictive	ADJ
bptjm-64	156	14	biomarkers	biomarker	NOUN
bptjm-64	156	15	of	of	ADP
bptjm-64	156	16	cpr	cpr	PROPN
bptjm-64	156	17	,	,	PUNCT
bptjm-64	156	18	in	in	ADP
bptjm-64	156	19	conjunction	conjunction	NOUN
bptjm-64	156	20	with	with	ADP
bptjm-64	156	21	neoadjuvant	neoadjuvant	ADJ
bptjm-64	156	22	immunotherapy.35	immunotherapy.35	NOUN
bptjm-64	156	23	5.2	5.2	NUM
bptjm-64	156	24	melanoma	melanoma	NOUN
bptjm-64	156	25	anti	anti	ADJ
bptjm-64	156	26	-	-	ADJ
bptjm-64	156	27	pd-1	pd-1	ADJ
bptjm-64	156	28	therapy	therapy	NOUN
bptjm-64	156	29	represents	represent	VERB
bptjm-64	156	30	a	a	DET
bptjm-64	156	31	standard	standard	ADJ
bptjm-64	156	32	immunotherapy	immunotherapy	NOUN
bptjm-64	156	33	regimen	regiman	NOUN
bptjm-64	156	34	for	for	ADP
bptjm-64	156	35	melanoma	melanoma	NOUN
bptjm-64	156	36	,	,	PUNCT
bptjm-64	156	37	a	a	DET
bptjm-64	156	38	type	type	NOUN
bptjm-64	156	39	of	of	ADP
bptjm-64	156	40	skin	skin	NOUN
bptjm-64	156	41	cancer	cancer	NOUN
bptjm-64	156	42	.	.	PUNCT
bptjm-64	157	1	however	however	ADV
bptjm-64	157	2	,	,	PUNCT
bptjm-64	157	3	this	this	DET
bptjm-64	157	4	treatment	treatment	NOUN
bptjm-64	157	5	modality	modality	NOUN
bptjm-64	157	6	is	be	AUX
bptjm-64	157	7	only	only	ADV
bptjm-64	157	8	e	e	X
bptjm-64	157	9	�	�	NOUN
bptjm-64	157	10	ective	ective	ADJ
bptjm-64	157	11	in	in	ADP
bptjm-64	157	12	providing	provide	VERB
bptjm-64	157	13	long	long	ADJ
bptjm-64	157	14	-	-	PUNCT
bptjm-64	157	15	term	term	NOUN
bptjm-64	157	16	clinical	clinical	ADJ
bptjm-64	157	17	bene	bene	PROPN
bptjm-64	157	18	�	�	PROPN
bptjm-64	157	19	ts	ts	ADP
bptjm-64	157	20	to	to	ADP
bptjm-64	157	21	approximately	approximately	ADV
bptjm-64	157	22	40	40	NUM
bptjm-64	157	23	%	%	NOUN
bptjm-64	157	24	of	of	ADP
bptjm-64	157	25	patients	patient	NOUN
bptjm-64	157	26	with	with	ADP
bptjm-64	157	27	advanced	advanced	ADJ
bptjm-64	157	28	melanoma.36	melanoma.36	NOUN
bptjm-64	157	29	to	to	PART
bptjm-64	157	30	address	address	VERB
bptjm-64	157	31	this	this	DET
bptjm-64	157	32	challenge	challenge	NOUN
bptjm-64	157	33	,	,	PUNCT
bptjm-64	157	34	davar	davar	PROPN
bptjm-64	157	35	et	et	PROPN
bptjm-64	157	36	al	al	PROPN
bptjm-64	157	37	.	.	PROPN
bptjm-64	157	38	conducted	conduct	VERB
bptjm-64	157	39	a	a	DET
bptjm-64	157	40	study	study	NOUN
bptjm-64	157	41	involving	involve	VERB
bptjm-64	157	42	the	the	DET
bptjm-64	157	43	administration	administration	NOUN
bptjm-64	157	44	of	of	ADP
bptjm-64	157	45	pembrolizumab	pembrolizumab	NOUN
bptjm-64	157	46	,	,	PUNCT
bptjm-64	157	47	an	an	DET
bptjm-64	157	48	anti	anti	ADJ
bptjm-64	157	49	-	-	ADJ
bptjm-64	157	50	pd-1	pd-1	ADJ
bptjm-64	157	51	drug	drug	NOUN
bptjm-64	157	52	,	,	PUNCT
bptjm-64	157	53	alongside	alongside	ADP
bptjm-64	157	54	a	a	DET
bptjm-64	157	55	fecal	fecal	ADJ
bptjm-64	157	56	microbiota	microbiota	NOUN
bptjm-64	157	57	transplant	transplant	NOUN
bptjm-64	157	58	(	(	PUNCT
bptjm-64	157	59	fmt	fmt	NOUN
bptjm-64	157	60	)	)	PUNCT
bptjm-64	157	61	in	in	ADP
bptjm-64	157	62	16	16	NUM
bptjm-64	157	63	patients	patient	NOUN
bptjm-64	157	64	with	with	ADP
bptjm-64	157	65	advanced	advanced	ADJ
bptjm-64	157	66	melanoma	melanoma	NOUN
bptjm-64	157	67	who	who	PRON
bptjm-64	157	68	did	do	AUX
bptjm-64	157	69	not	not	PART
bptjm-64	157	70	respond	respond	VERB
bptjm-64	157	71	to	to	ADP
bptjm-64	157	72	anti	anti	ADJ
bptjm-64	157	73	-	-	ADJ
bptjm-64	157	74	pd-1	pd-1	ADJ
bptjm-64	157	75	therapy	therapy	NOUN
bptjm-64	157	76	alone.36	alone.36	NOUN
bptjm-64	157	77	this	this	DET
bptjm-64	157	78	combined	combined	ADJ
bptjm-64	157	79	approach	approach	NOUN
bptjm-64	157	80	of	of	ADP
bptjm-64	157	81	fmt	fmt	NOUN
bptjm-64	157	82	and	and	CCONJ
bptjm-64	157	83	pd-1	pd-1	ADJ
bptjm-64	157	84	blockade	blockade	NOUN
bptjm-64	157	85	resulted	result	VERB
bptjm-64	157	86	in	in	ADP
bptjm-64	157	87	the	the	DET
bptjm-64	157	88	reprogramming	reprogramming	NOUN
bptjm-64	157	89	of	of	ADP
bptjm-64	157	90	the	the	DET
bptjm-64	157	91	tumor	tumor	NOUN
bptjm-64	157	92	microenvironment	microenvironment	NOUN
bptjm-64	157	93	(	(	PUNCT
bptjm-64	157	94	tme	tme	PROPN
bptjm-64	157	95	)	)	PUNCT
bptjm-64	157	96	,	,	PUNCT
bptjm-64	157	97	overcoming	overcome	VERB
bptjm-64	157	98	resistance	resistance	NOUN
bptjm-64	157	99	to	to	ADP
bptjm-64	157	100	anti	anti	ADJ
bptjm-64	157	101	-	-	ADJ
bptjm-64	157	102	pd-1	pd-1	ADJ
bptjm-64	157	103	therapy	therapy	NOUN
bptjm-64	157	104	.	.	PUNCT
bptjm-64	158	1	notably	notably	ADV
bptjm-64	158	2	,	,	PUNCT
bptjm-64	158	3	the	the	DET
bptjm-64	158	4	treatment	treatment	NOUN
bptjm-64	158	5	led	lead	VERB
bptjm-64	158	6	to	to	ADP
bptjm-64	158	7	the	the	DET
bptjm-64	158	8	upregulation	upregulation	NOUN
bptjm-64	158	9	of	of	ADP
bptjm-64	158	10	cd8	cd8	PROPN
bptjm-64	158	11	+	+	PROPN
bptjm-64	158	12	t	t	NOUN
bptjm-64	158	13	cells	cell	NOUN
bptjm-64	158	14	,	,	PUNCT
bptjm-64	158	15	a	a	DET
bptjm-64	158	16	decrease	decrease	NOUN
bptjm-64	158	17	in	in	ADP
bptjm-64	158	18	the	the	DET
bptjm-64	158	19	percentage	percentage	NOUN
bptjm-64	158	20	of	of	ADP
bptjm-64	158	21	naive	naive	ADJ
bptjm-64	158	22	cd8	cd8	PROPN
bptjm-64	158	23	+	+	PROPN
bptjm-64	158	24	t	t	NOUN
bptjm-64	158	25	cells	cell	NOUN
bptjm-64	158	26	,	,	PUNCT
bptjm-64	158	27	and	and	CCONJ
bptjm-64	158	28	an	an	DET
bptjm-64	158	29	increase	increase	NOUN
bptjm-64	158	30	in	in	ADP
bptjm-64	158	31	activated	activate	VERB
bptjm-64	158	32	and	and	CCONJ
bptjm-64	158	33	di	di	NOUN
bptjm-64	158	34	�	�	PROPN
bptjm-64	158	35	erentiated	erentiate	VERB
bptjm-64	158	36	cd8	cd8	PROPN
bptjm-64	158	37	+	+	PROPN
bptjm-64	158	38	t	t	NOUN
bptjm-64	158	39	cells	cell	NOUN
bptjm-64	158	40	.	.	PUNCT
bptjm-64	159	1	responders	responder	NOUN
bptjm-64	159	2	also	also	ADV
bptjm-64	159	3	exhibited	exhibit	VERB
bptjm-64	159	4	downregulation	downregulation	NOUN
bptjm-64	159	5	of	of	ADP
bptjm-64	159	6	cytokines	cytokine	NOUN
bptjm-64	159	7	and	and	CCONJ
bptjm-64	159	8	chemokines	chemokine	NOUN
bptjm-64	159	9	associated	associate	VERB
bptjm-64	159	10	with	with	ADP
bptjm-64	159	11	anti	anti	ADJ
bptjm-64	159	12	-	-	ADJ
bptjm-64	159	13	pd-1	pd-1	ADJ
bptjm-64	159	14	resistance	resistance	NOUN
bptjm-64	159	15	,	,	PUNCT
bptjm-64	159	16	along	along	ADP
bptjm-64	159	17	with	with	ADP
bptjm-64	159	18	upregulation	upregulation	NOUN
bptjm-64	159	19	of	of	ADP
bptjm-64	159	20	biomarkers	biomarker	NOUN
bptjm-64	159	21	linked	link	VERB
bptjm-64	159	22	to	to	ADP
bptjm-64	159	23	improved	improved	ADJ
bptjm-64	159	24	outcomes.36	outcomes.36	PROPN
bptjm-64	159	25	berkeley	berkeley	PROPN
bptjm-64	159	26	pharma	pharma	PROPN
bptjm-64	159	27	tech	tech	NOUN
bptjm-64	159	28	journal	journal	NOUN
bptjm-64	159	29	of	of	ADP
bptjm-64	159	30	medicine	medicine	NOUN
bptjm-64	160	1	|	|	ADV
bptjm-64	160	2	133	133	NUM
bptjm-64	160	3	a	a	DET
bptjm-64	160	4	recent	recent	ADJ
bptjm-64	160	5	approach	approach	NOUN
bptjm-64	160	6	in	in	ADP
bptjm-64	160	7	melanoma	melanoma	NOUN
bptjm-64	160	8	treatment	treatment	NOUN
bptjm-64	160	9	involves	involve	VERB
bptjm-64	160	10	categorizing	categorize	VERB
bptjm-64	160	11	the	the	DET
bptjm-64	160	12	tumor	tumor	NOUN
bptjm-64	160	13	microenvironment	microenvironment	NOUN
bptjm-64	160	14	(	(	PUNCT
bptjm-64	160	15	tme	tme	NOUN
bptjm-64	160	16	)	)	PUNCT
bptjm-64	160	17	to	to	PART
bptjm-64	160	18	anticipate	anticipate	VERB
bptjm-64	160	19	the	the	DET
bptjm-64	160	20	cancer	cancer	NOUN
bptjm-64	160	21	's	's	PART
bptjm-64	160	22	responsiveness	responsiveness	NOUN
bptjm-64	160	23	to	to	ADP
bptjm-64	160	24	immunotherapy	immunotherapy	NOUN
bptjm-64	160	25	.	.	PUNCT
bptjm-64	161	1	while	while	SCONJ
bptjm-64	161	2	combining	combine	VERB
bptjm-64	161	3	di	di	NOUN
bptjm-64	161	4	�	�	PROPN
bptjm-64	161	5	erent	erent	NOUN
bptjm-64	161	6	immune	immune	ADJ
bptjm-64	161	7	checkpoint	checkpoint	NOUN
bptjm-64	161	8	inhibitors	inhibitor	NOUN
bptjm-64	161	9	(	(	PUNCT
bptjm-64	161	10	icis	icis	NOUN
bptjm-64	161	11	)	)	PUNCT
bptjm-64	161	12	like	like	ADP
bptjm-64	161	13	anti	anti	ADJ
bptjm-64	161	14	-	-	ADJ
bptjm-64	161	15	pd-1	pd-1	ADJ
bptjm-64	161	16	and	and	CCONJ
bptjm-64	161	17	anti	anti	ADJ
bptjm-64	161	18	-	-	ADJ
bptjm-64	161	19	ctla-4	ctla-4	NOUN
bptjm-64	161	20	may	may	AUX
bptjm-64	161	21	appear	appear	VERB
bptjm-64	161	22	promising	promise	VERB
bptjm-64	161	23	,	,	PUNCT
bptjm-64	161	24	trials	trial	NOUN
bptjm-64	161	25	on	on	ADP
bptjm-64	161	26	advanced	advanced	ADJ
bptjm-64	161	27	melanoma	melanoma	NOUN
bptjm-64	161	28	patients	patient	NOUN
bptjm-64	161	29	showed	show	VERB
bptjm-64	161	30	severe	severe	ADJ
bptjm-64	161	31	immune	immune	NOUN
bptjm-64	161	32	-	-	PUNCT
bptjm-64	161	33	related	relate	VERB
bptjm-64	161	34	adverse	adverse	ADJ
bptjm-64	161	35	events	event	NOUN
bptjm-64	161	36	(	(	PUNCT
bptjm-64	161	37	iraes	iraes	NOUN
bptjm-64	161	38	)	)	PUNCT
bptjm-64	161	39	such	such	ADJ
bptjm-64	161	40	as	as	ADP
bptjm-64	161	41	hypophysitis	hypophysitis	NOUN
bptjm-64	161	42	,	,	PUNCT
bptjm-64	161	43	pneumonitis	pneumonitis	NOUN
bptjm-64	161	44	,	,	PUNCT
bptjm-64	161	45	and	and	CCONJ
bptjm-64	161	46	thyroiditis	thyroiditis	NOUN
bptjm-64	161	47	,	,	PUNCT
bptjm-64	161	48	likely	likely	ADJ
bptjm-64	161	49	due	due	ADP
bptjm-64	161	50	to	to	ADP
bptjm-64	161	51	the	the	DET
bptjm-64	161	52	distinct	distinct	ADJ
bptjm-64	161	53	mechanisms	mechanism	NOUN
bptjm-64	161	54	of	of	ADP
bptjm-64	161	55	t	t	PROPN
bptjm-64	161	56	cell	cell	NOUN
bptjm-64	161	57	inhibition	inhibition	NOUN
bptjm-64	161	58	—	—	PUNCT
bptjm-64	161	59	ctla-4	ctla-4	NUM
bptjm-64	161	60	acting	act	VERB
bptjm-64	161	61	on	on	ADP
bptjm-64	161	62	t	t	PROPN
bptjm-64	161	63	cell	cell	NOUN
bptjm-64	161	64	activation	activation	NOUN
bptjm-64	161	65	,	,	PUNCT
bptjm-64	161	66	while	while	SCONJ
bptjm-64	161	67	pd-1	pd-1	ADV
bptjm-64	161	68	intervenes	intervene	VERB
bptjm-64	161	69	later.14	later.14	PROPN
bptjm-64	161	70	a	a	DET
bptjm-64	161	71	recent	recent	ADJ
bptjm-64	161	72	study	study	NOUN
bptjm-64	161	73	identi	identi	NOUN
bptjm-64	161	74	�	�	PROPN
bptjm-64	161	75	ed	ed	ADJ
bptjm-64	161	76	29	29	NUM
bptjm-64	161	77	functional	functional	ADJ
bptjm-64	161	78	gene	gene	NOUN
bptjm-64	161	79	expression	expression	NOUN
bptjm-64	161	80	signatures	signature	NOUN
bptjm-64	161	81	(	(	PUNCT
bptjm-64	161	82	fges	fge	NOUN
bptjm-64	161	83	)	)	PUNCT
bptjm-64	161	84	delineating	delineate	VERB
bptjm-64	161	85	major	major	ADJ
bptjm-64	161	86	functional	functional	ADJ
bptjm-64	161	87	and	and	CCONJ
bptjm-64	161	88	cellular	cellular	ADJ
bptjm-64	161	89	components	component	NOUN
bptjm-64	161	90	of	of	ADP
bptjm-64	161	91	melanoma	melanoma	NOUN
bptjm-64	161	92	tumors	tumor	NOUN
bptjm-64	161	93	,	,	PUNCT
bptjm-64	161	94	classifying	classify	VERB
bptjm-64	161	95	them	they	PRON
bptjm-64	161	96	into	into	ADP
bptjm-64	161	97	four	four	NUM
bptjm-64	161	98	subtypes	subtype	NOUN
bptjm-64	161	99	:	:	PUNCT
bptjm-64	161	100	immune	immune	NOUN
bptjm-64	161	101	-	-	PUNCT
bptjm-64	161	102	enriched/	enriched/	NUM
bptjm-64	161	103	�	�	NOUN
bptjm-64	161	104	brotic	brotic	NOUN
bptjm-64	161	105	(	(	PUNCT
bptjm-64	161	106	elevated	elevated	ADJ
bptjm-64	161	107	angiogenesis	angiogenesis	NOUN
bptjm-64	161	108	and	and	CCONJ
bptjm-64	161	109	cancer	cancer	NOUN
bptjm-64	161	110	-	-	PUNCT
bptjm-64	161	111	associated	associate	VERB
bptjm-64	161	112	fibroblast	fibroblast	ADJ
bptjm-64	161	113	activation	activation	NOUN
bptjm-64	161	114	)	)	PUNCT
bptjm-64	161	115	,	,	PUNCT
bptjm-64	161	116	immune	immune	NOUN
bptjm-64	161	117	-	-	PUNCT
bptjm-64	161	118	enriched	enrich	VERB
bptjm-64	161	119	/	/	SYM
bptjm-64	161	120	non-	non-	SYM
bptjm-64	161	121	�	�	NOUN
bptjm-64	161	122	brotic	brotic	ADJ
bptjm-64	161	123	(	(	PUNCT
bptjm-64	161	124	more	more	ADJ
bptjm-64	161	125	immune	immune	ADJ
bptjm-64	161	126	-	-	PUNCT
bptjm-64	161	127	active	active	ADJ
bptjm-64	161	128	tme	tme	NOUN
bptjm-64	161	129	)	)	PUNCT
bptjm-64	161	130	,	,	PUNCT
bptjm-64	161	131	�	�	PROPN
bptjm-64	161	132	brotic	brotic	ADJ
bptjm-64	161	133	(	(	PUNCT
bptjm-64	161	134	low	low	ADJ
bptjm-64	161	135	lymphocyte	lymphocyte	NOUN
bptjm-64	161	136	in	in	ADP
bptjm-64	161	137	�	�	PROPN
bptjm-64	161	138	ltration	ltration	NOUN
bptjm-64	161	139	,	,	PUNCT
bptjm-64	161	140	high	high	ADJ
bptjm-64	161	141	�	�	PROPN
bptjm-64	161	142	broblast	broblast	ADJ
bptjm-64	161	143	activity	activity	NOUN
bptjm-64	161	144	)	)	PUNCT
bptjm-64	161	145	,	,	PUNCT
bptjm-64	161	146	and	and	CCONJ
bptjm-64	161	147	immune	immune	NOUN
bptjm-64	161	148	-	-	PUNCT
bptjm-64	161	149	depleted	deplete	VERB
bptjm-64	161	150	(	(	PUNCT
bptjm-64	161	151	immune	immune	NOUN
bptjm-64	161	152	-	-	PUNCT
bptjm-64	161	153	desert).37	desert).37	PROPN
bptjm-64	161	154	this	this	DET
bptjm-64	161	155	classi	classi	PROPN
bptjm-64	161	156	�	�	PROPN
bptjm-64	161	157	cation	cation	NOUN
bptjm-64	161	158	aids	aid	NOUN
bptjm-64	161	159	in	in	ADP
bptjm-64	161	160	determining	determine	VERB
bptjm-64	161	161	treatment	treatment	NOUN
bptjm-64	161	162	e	e	NOUN
bptjm-64	161	163	�	�	NOUN
bptjm-64	161	164	ectiveness	ectiveness	NOUN
bptjm-64	161	165	and	and	CCONJ
bptjm-64	161	166	alternative	alternative	ADJ
bptjm-64	161	167	approaches	approach	NOUN
bptjm-64	161	168	.	.	PUNCT
bptjm-64	162	1	for	for	ADP
bptjm-64	162	2	instance	instance	NOUN
bptjm-64	162	3	,	,	PUNCT
bptjm-64	162	4	responses	response	NOUN
bptjm-64	162	5	to	to	ADP
bptjm-64	162	6	anti	anti	ADJ
bptjm-64	162	7	-	-	ADJ
bptjm-64	162	8	ctla-4	ctla-4	NOUN
bptjm-64	162	9	treatment	treatment	NOUN
bptjm-64	162	10	varied	varied	ADJ
bptjm-64	162	11	across	across	ADP
bptjm-64	162	12	subtypes	subtype	NOUN
bptjm-64	162	13	,	,	PUNCT
bptjm-64	162	14	with	with	ADP
bptjm-64	162	15	82	82	NUM
bptjm-64	162	16	%	%	NOUN
bptjm-64	162	17	of	of	ADP
bptjm-64	162	18	immune	immune	NOUN
bptjm-64	162	19	-	-	PUNCT
bptjm-64	162	20	enriched	enrich	VERB
bptjm-64	162	21	subtypes	subtype	NOUN
bptjm-64	162	22	responding	respond	VERB
bptjm-64	162	23	compared	compare	VERB
bptjm-64	162	24	to	to	ADP
bptjm-64	162	25	only	only	ADV
bptjm-64	162	26	10	10	NUM
bptjm-64	162	27	%	%	NOUN
bptjm-64	162	28	of	of	ADP
bptjm-64	162	29	�	�	NOUN
bptjm-64	162	30	brotic	brotic	ADJ
bptjm-64	162	31	subtype	subtype	NOUN
bptjm-64	162	32	,	,	PUNCT
bptjm-64	162	33	suggesting	suggest	VERB
bptjm-64	162	34	appropriate	appropriate	ADJ
bptjm-64	162	35	utilization	utilization	NOUN
bptjm-64	162	36	of	of	ADP
bptjm-64	162	37	ici	ici	PROPN
bptjm-64	162	38	immunotherapy.37	immunotherapy.37	PROPN
bptjm-64	162	39	5.3	5.3	NUM
bptjm-64	162	40	other	other	ADJ
bptjm-64	162	41	cancers	cancer	NOUN
bptjm-64	162	42	(	(	PUNCT
bptjm-64	162	43	novel	novel	ADJ
bptjm-64	162	44	treatments	treatment	NOUN
bptjm-64	162	45	/	/	SYM
bptjm-64	162	46	combination	combination	NOUN
bptjm-64	162	47	therapies	therapy	NOUN
bptjm-64	162	48	)	)	PUNCT
bptjm-64	162	49	pancreatic	pancreatic	ADJ
bptjm-64	162	50	cancer	cancer	NOUN
bptjm-64	162	51	(	(	PUNCT
bptjm-64	162	52	pdac	pdac	NOUN
bptjm-64	162	53	)	)	PUNCT
bptjm-64	162	54	poses	pose	VERB
bptjm-64	162	55	a	a	DET
bptjm-64	162	56	signi	signi	ADJ
bptjm-64	162	57	�	�	NOUN
bptjm-64	162	58	cant	cant	NOUN
bptjm-64	162	59	challenge	challenge	NOUN
bptjm-64	162	60	for	for	ADP
bptjm-64	162	61	immunotherapy	immunotherapy	NOUN
bptjm-64	162	62	due	due	ADP
bptjm-64	162	63	to	to	ADP
bptjm-64	162	64	its	its	PRON
bptjm-64	162	65	low	low	ADJ
bptjm-64	162	66	t	t	NOUN
bptjm-64	162	67	cell	cell	NOUN
bptjm-64	162	68	in	in	ADP
bptjm-64	162	69	�	�	PROPN
bptjm-64	162	70	ltration	ltration	NOUN
bptjm-64	162	71	,	,	PUNCT
bptjm-64	162	72	low	low	ADJ
bptjm-64	162	73	tumor	tumor	NOUN
bptjm-64	162	74	mutational	mutational	ADJ
bptjm-64	162	75	burden	burden	NOUN
bptjm-64	162	76	,	,	PUNCT
bptjm-64	162	77	and	and	CCONJ
bptjm-64	162	78	highly	highly	ADV
bptjm-64	162	79	suppressive	suppressive	ADJ
bptjm-64	162	80	tumor	tumor	NOUN
bptjm-64	162	81	microenvironment	microenvironment	NOUN
bptjm-64	162	82	(	(	PUNCT
bptjm-64	162	83	tme	tme	NOUN
bptjm-64	162	84	)	)	PUNCT
bptjm-64	162	85	,	,	PUNCT
bptjm-64	162	86	making	make	VERB
bptjm-64	162	87	it	it	PRON
bptjm-64	162	88	the	the	DET
bptjm-64	162	89	fourth	fourth	ADJ
bptjm-64	162	90	leading	leading	ADJ
bptjm-64	162	91	cause	cause	NOUN
bptjm-64	162	92	of	of	ADP
bptjm-64	162	93	cancer	cancer	NOUN
bptjm-64	162	94	-	-	PUNCT
bptjm-64	162	95	related	relate	VERB
bptjm-64	162	96	deaths.44	deaths.44	NOUN
bptjm-64	162	97	combination	combination	NOUN
bptjm-64	162	98	therapy	therapy	NOUN
bptjm-64	162	99	emerges	emerge	VERB
bptjm-64	162	100	as	as	ADP
bptjm-64	162	101	a	a	DET
bptjm-64	162	102	promising	promising	ADJ
bptjm-64	162	103	approach	approach	NOUN
bptjm-64	162	104	,	,	PUNCT
bptjm-64	162	105	as	as	SCONJ
bptjm-64	162	106	demonstrated	demonstrate	VERB
bptjm-64	162	107	in	in	ADP
bptjm-64	162	108	a	a	DET
bptjm-64	162	109	recent	recent	ADJ
bptjm-64	162	110	study	study	NOUN
bptjm-64	162	111	by	by	ADP
bptjm-64	162	112	padron	padron	PROPN
bptjm-64	162	113	et	et	PROPN
bptjm-64	162	114	al	al	PROPN
bptjm-64	162	115	.	.	PUNCT
bptjm-64	163	1	this	this	DET
bptjm-64	163	2	study	study	NOUN
bptjm-64	163	3	investigated	investigate	VERB
bptjm-64	163	4	the	the	DET
bptjm-64	163	5	administration	administration	NOUN
bptjm-64	163	6	of	of	ADP
bptjm-64	163	7	sotigalimab	sotigalimab	NOUN
bptjm-64	163	8	and/or	and/or	CCONJ
bptjm-64	163	9	nivolumab	nivolumab	NOUN
bptjm-64	163	10	(	(	PUNCT
bptjm-64	163	11	both	both	CCONJ
bptjm-64	163	12	anti	anti	ADJ
bptjm-64	163	13	-	-	ADJ
bptjm-64	163	14	pd-1	pd-1	ADJ
bptjm-64	163	15	drugs	drug	NOUN
bptjm-64	163	16	)	)	PUNCT
bptjm-64	163	17	alongside	alongside	ADP
bptjm-64	163	18	chemotherapy.38	chemotherapy.38	PROPN
bptjm-64	163	19	the	the	DET
bptjm-64	163	20	results	result	NOUN
bptjm-64	163	21	revealed	reveal	VERB
bptjm-64	163	22	that	that	SCONJ
bptjm-64	163	23	combining	combine	VERB
bptjm-64	163	24	nivolumab	nivolumab	NOUN
bptjm-64	163	25	with	with	ADP
bptjm-64	163	26	chemotherapy	chemotherapy	NOUN
bptjm-64	163	27	was	be	AUX
bptjm-64	163	28	associated	associate	VERB
bptjm-64	163	29	with	with	ADP
bptjm-64	163	30	a	a	DET
bptjm-64	163	31	less	less	ADV
bptjm-64	163	32	suppressive	suppressive	ADJ
bptjm-64	163	33	tme	tme	PROPN
bptjm-64	163	34	,	,	PUNCT
bptjm-64	163	35	increased	increase	VERB
bptjm-64	163	36	numbers	number	NOUN
bptjm-64	163	37	of	of	ADP
bptjm-64	163	38	activated	activated	ADJ
bptjm-64	163	39	and	and	CCONJ
bptjm-64	163	40	circulating	circulating	ADJ
bptjm-64	163	41	t	t	NOUN
bptjm-64	163	42	cells	cell	NOUN
bptjm-64	163	43	,	,	PUNCT
bptjm-64	163	44	and	and	CCONJ
bptjm-64	163	45	achieved	achieve	VERB
bptjm-64	163	46	the	the	DET
bptjm-64	163	47	primary	primary	ADJ
bptjm-64	163	48	endpoint	endpoint	NOUN
bptjm-64	163	49	of	of	ADP
bptjm-64	163	50	one	one	NUM
bptjm-64	163	51	-	-	PUNCT
bptjm-64	163	52	year	year	NOUN
bptjm-64	163	53	overall	overall	ADJ
bptjm-64	163	54	survival	survival	NOUN
bptjm-64	163	55	(	(	PUNCT
bptjm-64	163	56	os	os	NOUN
bptjm-64	163	57	)	)	PUNCT
bptjm-64	163	58	.	.	PUNCT
bptjm-64	164	1	although	although	SCONJ
bptjm-64	164	2	sotigalimab	sotigalimab	NOUN
bptjm-64	164	3	combined	combine	VERB
bptjm-64	164	4	with	with	ADP
bptjm-64	164	5	chemotherapy	chemotherapy	NOUN
bptjm-64	164	6	did	do	AUX
bptjm-64	164	7	not	not	PART
bptjm-64	164	8	meet	meet	VERB
bptjm-64	164	9	the	the	DET
bptjm-64	164	10	os	os	NOUN
bptjm-64	164	11	endpoint	endpoint	NOUN
bptjm-64	164	12	,	,	PUNCT
bptjm-64	164	13	it	it	PRON
bptjm-64	164	14	led	lead	VERB
bptjm-64	164	15	to	to	ADP
bptjm-64	164	16	greater	great	ADJ
bptjm-64	164	17	in	in	ADP
bptjm-64	164	18	�	�	NOUN
bptjm-64	164	19	ltration	ltration	NOUN
bptjm-64	164	20	and	and	CCONJ
bptjm-64	164	21	di	di	NOUN
bptjm-64	164	22	�	�	PROPN
bptjm-64	164	23	erentiation	erentiation	NOUN
bptjm-64	164	24	of	of	ADP
bptjm-64	164	25	cd4	cd4	PROPN
bptjm-64	164	26	+	+	PROPN
bptjm-64	164	27	cells	cell	NOUN
bptjm-64	164	28	.	.	PUNCT
bptjm-64	165	1	interestingly	interestingly	ADV
bptjm-64	165	2	,	,	PUNCT
bptjm-64	165	3	administering	administer	VERB
bptjm-64	165	4	all	all	DET
bptjm-64	165	5	three	three	NUM
bptjm-64	165	6	components	component	NOUN
bptjm-64	165	7	together	together	ADV
bptjm-64	165	8	did	do	AUX
bptjm-64	165	9	not	not	PART
bptjm-64	165	10	yield	yield	VERB
bptjm-64	165	11	additional	additional	ADJ
bptjm-64	165	12	improvements.38	improvements.38	PROPN
bptjm-64	165	13	berkeley	berkeley	PROPN
bptjm-64	165	14	pharma	pharma	PROPN
bptjm-64	165	15	tech	tech	NOUN
bptjm-64	165	16	journal	journal	NOUN
bptjm-64	165	17	of	of	ADP
bptjm-64	165	18	medicine	medicine	NOUN
bptjm-64	165	19	|	|	ADV
bptjm-64	165	20	134	134	NUM
bptjm-64	165	21	cervical	cervical	ADJ
bptjm-64	165	22	cancer	cancer	NOUN
bptjm-64	165	23	(	(	PUNCT
bptjm-64	165	24	cc	cc	NOUN
bptjm-64	165	25	)	)	PUNCT
bptjm-64	165	26	ranks	rank	VERB
bptjm-64	165	27	as	as	ADP
bptjm-64	165	28	the	the	DET
bptjm-64	165	29	fourth	fourth	ADJ
bptjm-64	165	30	most	most	ADV
bptjm-64	165	31	prevalent	prevalent	ADJ
bptjm-64	165	32	cancer	cancer	NOUN
bptjm-64	165	33	,	,	PUNCT
bptjm-64	165	34	with	with	ADP
bptjm-64	165	35	concurrent	concurrent	ADJ
bptjm-64	165	36	chemoradiotherapy	chemoradiotherapy	NOUN
bptjm-64	165	37	(	(	PUNCT
bptjm-64	165	38	ccrt	ccrt	NOUN
bptjm-64	165	39	)	)	PUNCT
bptjm-64	165	40	serving	serve	VERB
bptjm-64	165	41	as	as	ADP
bptjm-64	165	42	the	the	DET
bptjm-64	165	43	standard	standard	ADJ
bptjm-64	165	44	treatment.39	treatment.39	NOUN
bptjm-64	165	45	however	however	ADV
bptjm-64	165	46	,	,	PUNCT
bptjm-64	165	47	individuals	individual	NOUN
bptjm-64	165	48	with	with	ADP
bptjm-64	165	49	advanced	advanced	ADJ
bptjm-64	165	50	-	-	PUNCT
bptjm-64	165	51	stage	stage	NOUN
bptjm-64	165	52	disease	disease	NOUN
bptjm-64	165	53	often	often	ADV
bptjm-64	165	54	experience	experience	VERB
bptjm-64	165	55	diminished	diminish	VERB
bptjm-64	165	56	long	long	ADJ
bptjm-64	165	57	-	-	PUNCT
bptjm-64	165	58	term	term	NOUN
bptjm-64	165	59	outcomes	outcome	NOUN
bptjm-64	165	60	,	,	PUNCT
bptjm-64	165	61	prompting	prompt	VERB
bptjm-64	165	62	investigation	investigation	NOUN
bptjm-64	165	63	into	into	ADP
bptjm-64	165	64	combination	combination	NOUN
bptjm-64	165	65	therapies	therapy	NOUN
bptjm-64	165	66	.	.	PUNCT
bptjm-64	166	1	a	a	DET
bptjm-64	166	2	recent	recent	ADJ
bptjm-64	166	3	study	study	NOUN
bptjm-64	166	4	by	by	ADP
bptjm-64	166	5	huang	huang	PROPN
bptjm-64	166	6	et	et	PROPN
bptjm-64	166	7	al	al	PROPN
bptjm-64	166	8	.	.	PROPN
bptjm-64	167	1	in	in	ADP
bptjm-64	167	2	august	august	PROPN
bptjm-64	167	3	2022	2022	NUM
bptjm-64	167	4	explored	explore	VERB
bptjm-64	167	5	the	the	DET
bptjm-64	167	6	utilization	utilization	NOUN
bptjm-64	167	7	of	of	ADP
bptjm-64	167	8	adoptive	adoptive	ADJ
bptjm-64	167	9	cell	cell	NOUN
bptjm-64	167	10	therapy	therapy	NOUN
bptjm-64	167	11	(	(	PUNCT
bptjm-64	167	12	act	act	PROPN
bptjm-64	167	13	)	)	PUNCT
bptjm-64	167	14	,	,	PUNCT
bptjm-64	167	15	a	a	DET
bptjm-64	167	16	form	form	NOUN
bptjm-64	167	17	of	of	ADP
bptjm-64	167	18	immunotherapy	immunotherapy	NOUN
bptjm-64	167	19	involving	involve	VERB
bptjm-64	167	20	the	the	DET
bptjm-64	167	21	introduction	introduction	NOUN
bptjm-64	167	22	of	of	ADP
bptjm-64	167	23	tumor	tumor	NOUN
bptjm-64	167	24	-	-	PUNCT
bptjm-64	167	25	in	in	ADP
bptjm-64	167	26	�	�	NOUN
bptjm-64	167	27	ltrating	ltrating	NOUN
bptjm-64	167	28	lymphocytes	lymphocyte	NOUN
bptjm-64	167	29	(	(	PUNCT
bptjm-64	167	30	tils	til	NOUN
bptjm-64	167	31	)	)	PUNCT
bptjm-64	167	32	to	to	PART
bptjm-64	167	33	evoke	evoke	VERB
bptjm-64	167	34	an	an	DET
bptjm-64	167	35	immune	immune	ADJ
bptjm-64	167	36	response	response	NOUN
bptjm-64	167	37	,	,	PUNCT
bptjm-64	167	38	following	follow	VERB
bptjm-64	167	39	ccrt	ccrt	NOUN
bptjm-64	167	40	and	and	CCONJ
bptjm-64	167	41	its	its	PRON
bptjm-64	167	42	impact	impact	NOUN
bptjm-64	167	43	on	on	ADP
bptjm-64	167	44	survival.39	survival.39	NOUN
bptjm-64	167	45	among	among	ADP
bptjm-64	167	46	the	the	DET
bptjm-64	167	47	27	27	NUM
bptjm-64	167	48	patients	patient	NOUN
bptjm-64	167	49	receiving	receive	VERB
bptjm-64	167	50	act	act	NOUN
bptjm-64	167	51	alone	alone	ADV
bptjm-64	167	52	,	,	PUNCT
bptjm-64	167	53	20	20	NUM
bptjm-64	167	54	saw	see	VERB
bptjm-64	167	55	successful	successful	ADJ
bptjm-64	167	56	expansion	expansion	NOUN
bptjm-64	167	57	of	of	ADP
bptjm-64	167	58	tils	til	NOUN
bptjm-64	167	59	.	.	PUNCT
bptjm-64	168	1	subsequently	subsequently	ADV
bptjm-64	168	2	,	,	PUNCT
bptjm-64	168	3	12	12	NUM
bptjm-64	168	4	patients	patient	NOUN
bptjm-64	168	5	received	receive	VERB
bptjm-64	168	6	tils	til	VERB
bptjm-64	168	7	post	post	ADJ
bptjm-64	168	8	-	-	ADJ
bptjm-64	168	9	ccrt	ccrt	ADJ
bptjm-64	168	10	,	,	PUNCT
bptjm-64	168	11	with	with	ADP
bptjm-64	168	12	75	75	NUM
bptjm-64	168	13	%	%	NOUN
bptjm-64	168	14	experiencing	experience	VERB
bptjm-64	168	15	complete	complete	ADJ
bptjm-64	168	16	response	response	NOUN
bptjm-64	168	17	and	and	CCONJ
bptjm-64	168	18	a	a	DET
bptjm-64	168	19	disease	disease	NOUN
bptjm-64	168	20	control	control	NOUN
bptjm-64	168	21	duration	duration	NOUN
bptjm-64	168	22	ranging	range	VERB
bptjm-64	168	23	from	from	ADP
bptjm-64	168	24	9	9	NUM
bptjm-64	168	25	to	to	ADP
bptjm-64	168	26	22	22	NUM
bptjm-64	168	27	months	month	NOUN
bptjm-64	168	28	.	.	PUNCT
bptjm-64	169	1	treatment	treatment	NOUN
bptjm-64	169	2	-	-	PUNCT
bptjm-64	169	3	related	relate	VERB
bptjm-64	169	4	adverse	adverse	ADJ
bptjm-64	169	5	events	event	NOUN
bptjm-64	169	6	were	be	AUX
bptjm-64	169	7	minimal	minimal	ADJ
bptjm-64	169	8	,	,	PUNCT
bptjm-64	169	9	with	with	ADP
bptjm-64	169	10	only	only	ADV
bptjm-64	169	11	one	one	NUM
bptjm-64	169	12	patient	patient	NOUN
bptjm-64	169	13	encountering	encounter	VERB
bptjm-64	169	14	severe	severe	ADJ
bptjm-64	169	15	toxicity	toxicity	NOUN
bptjm-64	169	16	,	,	PUNCT
bptjm-64	169	17	underscoring	underscore	VERB
bptjm-64	169	18	the	the	DET
bptjm-64	169	19	potential	potential	NOUN
bptjm-64	169	20	of	of	ADP
bptjm-64	169	21	post	post	ADJ
bptjm-64	169	22	-	-	ADJ
bptjm-64	169	23	ccrt	ccrt	ADJ
bptjm-64	169	24	act	act	NOUN
bptjm-64	169	25	in	in	ADP
bptjm-64	169	26	managing	manage	VERB
bptjm-64	169	27	cc.39	cc.39	PROPN
bptjm-64	169	28	e	e	ADJ
bptjm-64	169	29	�	�	NOUN
bptjm-64	169	30	ective	ective	ADJ
bptjm-64	169	31	combination	combination	NOUN
bptjm-64	169	32	therapy	therapy	NOUN
bptjm-64	169	33	entails	entail	VERB
bptjm-64	169	34	strategic	strategic	ADJ
bptjm-64	169	35	timing	timing	NOUN
bptjm-64	169	36	of	of	ADP
bptjm-64	169	37	treatments	treatment	NOUN
bptjm-64	169	38	.	.	PUNCT
bptjm-64	170	1	another	another	DET
bptjm-64	170	2	study	study	NOUN
bptjm-64	170	3	focused	focus	VERB
bptjm-64	170	4	on	on	ADP
bptjm-64	170	5	determining	determine	VERB
bptjm-64	170	6	the	the	DET
bptjm-64	170	7	optimal	optimal	ADJ
bptjm-64	170	8	timing	timing	NOUN
bptjm-64	170	9	for	for	ADP
bptjm-64	170	10	immune	immune	ADJ
bptjm-64	170	11	therapy	therapy	NOUN
bptjm-64	170	12	concerning	concern	VERB
bptjm-64	170	13	ccrt	ccrt	NOUN
bptjm-64	170	14	revealed	reveal	VERB
bptjm-64	170	15	the	the	DET
bptjm-64	170	16	bene	bene	PROPN
bptjm-64	170	17	�	�	PROPN
bptjm-64	170	18	t	t	PROPN
bptjm-64	170	19	of	of	ADP
bptjm-64	170	20	administering	administer	VERB
bptjm-64	170	21	immune	immune	ADJ
bptjm-64	170	22	checkpoint	checkpoint	NOUN
bptjm-64	170	23	inhibitors	inhibitor	NOUN
bptjm-64	170	24	(	(	PUNCT
bptjm-64	170	25	icis	icis	NOUN
bptjm-64	170	26	)	)	PUNCT
bptjm-64	170	27	before	before	ADP
bptjm-64	170	28	ccrt	ccrt	NOUN
bptjm-64	170	29	.	.	PUNCT
bptjm-64	171	1	this	this	DET
bptjm-64	171	2	strategy	strategy	NOUN
bptjm-64	171	3	capitalizes	capitalize	VERB
bptjm-64	171	4	on	on	ADP
bptjm-64	171	5	maintaining	maintain	VERB
bptjm-64	171	6	tumor	tumor	NOUN
bptjm-64	171	7	-	-	PUNCT
bptjm-64	171	8	speci	speci	NOUN
bptjm-64	171	9	�	�	PROPN
bptjm-64	171	10	c	c	PROPN
bptjm-64	171	11	immune	immune	ADJ
bptjm-64	171	12	response	response	NOUN
bptjm-64	171	13	,	,	PUNCT
bptjm-64	171	14	as	as	SCONJ
bptjm-64	171	15	it	it	PRON
bptjm-64	171	16	was	be	AUX
bptjm-64	171	17	observed	observe	VERB
bptjm-64	171	18	to	to	PART
bptjm-64	171	19	diminish	diminish	VERB
bptjm-64	171	20	following	follow	VERB
bptjm-64	171	21	ccrt	ccrt	NOUN
bptjm-64	171	22	.	.	PUNCT
bptjm-64	172	1	post	post	ADJ
bptjm-64	172	2	-	-	ADJ
bptjm-64	172	3	ccrt	ccrt	ADJ
bptjm-64	172	4	,	,	PUNCT
bptjm-64	172	5	reduced	reduce	VERB
bptjm-64	172	6	numbers	number	NOUN
bptjm-64	172	7	of	of	ADP
bptjm-64	172	8	cytotoxic	cytotoxic	ADJ
bptjm-64	172	9	t	t	NOUN
bptjm-64	172	10	lymphocytes	lymphocyte	NOUN
bptjm-64	172	11	(	(	PUNCT
bptjm-64	172	12	ctls	ctls	PROPN
bptjm-64	172	13	)	)	PUNCT
bptjm-64	172	14	,	,	PUNCT
bptjm-64	172	15	decreased	decrease	VERB
bptjm-64	172	16	t	t	PROPN
bptjm-64	172	17	cell	cell	NOUN
bptjm-64	172	18	receptor	receptor	NOUN
bptjm-64	172	19	(	(	PUNCT
bptjm-64	172	20	tcr	tcr	PROPN
bptjm-64	172	21	)	)	PUNCT
bptjm-64	172	22	diversity	diversity	NOUN
bptjm-64	172	23	,	,	PUNCT
bptjm-64	172	24	and	and	CCONJ
bptjm-64	172	25	increased	increase	VERB
bptjm-64	172	26	regulatory	regulatory	ADJ
bptjm-64	172	27	t	t	NOUN
bptjm-64	172	28	cells	cell	NOUN
bptjm-64	172	29	(	(	PUNCT
bptjm-64	172	30	tregs	treg	NOUN
bptjm-64	172	31	)	)	PUNCT
bptjm-64	172	32	signi	signi	PROPN
bptjm-64	172	33	�	�	PROPN
bptjm-64	172	34	ed	ed	PROPN
bptjm-64	172	35	a	a	DET
bptjm-64	172	36	weakened	weaken	VERB
bptjm-64	172	37	antitumor	antitumor	PROPN
bptjm-64	172	38	immune	immune	ADJ
bptjm-64	172	39	response.40	response.40	NOUN
bptjm-64	172	40	researchers	researcher	NOUN
bptjm-64	172	41	are	be	AUX
bptjm-64	172	42	investigating	investigate	VERB
bptjm-64	172	43	new	new	ADJ
bptjm-64	172	44	treatment	treatment	NOUN
bptjm-64	172	45	avenues	avenue	NOUN
bptjm-64	172	46	for	for	ADP
bptjm-64	172	47	chronic	chronic	ADJ
bptjm-64	172	48	lymphocytic	lymphocytic	ADJ
bptjm-64	172	49	leukemia	leukemia	NOUN
bptjm-64	172	50	(	(	PUNCT
bptjm-64	172	51	cll	cll	PROPN
bptjm-64	172	52	)	)	PUNCT
bptjm-64	172	53	that	that	PRON
bptjm-64	172	54	focus	focus	VERB
bptjm-64	172	55	on	on	ADP
bptjm-64	172	56	targeting	target	VERB
bptjm-64	172	57	lag-3	lag-3	NOUN
bptjm-64	172	58	,	,	PUNCT
bptjm-64	172	59	a	a	DET
bptjm-64	172	60	protein	protein	NOUN
bptjm-64	172	61	involved	involve	VERB
bptjm-64	172	62	in	in	ADP
bptjm-64	172	63	inhibiting	inhibit	VERB
bptjm-64	172	64	the	the	DET
bptjm-64	172	65	function	function	NOUN
bptjm-64	172	66	of	of	ADP
bptjm-64	172	67	natural	natural	ADJ
bptjm-64	172	68	killer	killer	NOUN
bptjm-64	172	69	(	(	PUNCT
bptjm-64	172	70	nk	nk	PROPN
bptjm-64	172	71	)	)	PUNCT
bptjm-64	172	72	cells	cell	NOUN
bptjm-64	172	73	and	and	CCONJ
bptjm-64	172	74	cd8	cd8	PROPN
bptjm-64	172	75	+	+	PROPN
bptjm-64	172	76	t	t	NOUN
bptjm-64	172	77	cells	cell	NOUN
bptjm-64	172	78	.	.	PUNCT
bptjm-64	173	1	in	in	ADP
bptjm-64	173	2	cll	cll	PROPN
bptjm-64	173	3	,	,	PUNCT
bptjm-64	173	4	lag-3	lag-3	X
bptjm-64	173	5	expression	expression	NOUN
bptjm-64	173	6	on	on	ADP
bptjm-64	173	7	leukemic	leukemic	ADJ
bptjm-64	173	8	cells	cell	NOUN
bptjm-64	173	9	is	be	AUX
bptjm-64	173	10	associated	associate	VERB
bptjm-64	173	11	with	with	ADP
bptjm-64	173	12	poorer	poor	ADJ
bptjm-64	173	13	outcomes	outcome	NOUN
bptjm-64	173	14	and	and	CCONJ
bptjm-64	173	15	decreased	decrease	VERB
bptjm-64	173	16	response	response	NOUN
bptjm-64	173	17	to	to	ADP
bptjm-64	173	18	treatment.20	treatment.20	PROPN
bptjm-64	173	19	relatlimab	relatlimab	NOUN
bptjm-64	173	20	,	,	PUNCT
bptjm-64	173	21	an	an	DET
bptjm-64	173	22	igg4	igg4	NOUN
bptjm-64	173	23	antibody	antibody	NOUN
bptjm-64	173	24	that	that	PRON
bptjm-64	173	25	blocks	block	VERB
bptjm-64	173	26	lag-3	lag-3	NUM
bptjm-64	173	27	,	,	PUNCT
bptjm-64	173	28	has	have	AUX
bptjm-64	173	29	shown	show	VERB
bptjm-64	173	30	promise	promise	NOUN
bptjm-64	173	31	in	in	ADP
bptjm-64	173	32	preclinical	preclinical	ADJ
bptjm-64	173	33	studies	study	NOUN
bptjm-64	173	34	.	.	PUNCT
bptjm-64	174	1	administering	administer	VERB
bptjm-64	174	2	relatlimab	relatlimab	NOUN
bptjm-64	174	3	increased	increase	VERB
bptjm-64	174	4	the	the	DET
bptjm-64	174	5	proliferation	proliferation	NOUN
bptjm-64	174	6	of	of	ADP
bptjm-64	174	7	nk	nk	PROPN
bptjm-64	174	8	cells	cell	NOUN
bptjm-64	174	9	and	and	CCONJ
bptjm-64	174	10	cd8	cd8	PROPN
bptjm-64	174	11	+	+	PROPN
bptjm-64	174	12	t	t	PROPN
bptjm-64	174	13	cells	cell	NOUN
bptjm-64	174	14	without	without	ADP
bptjm-64	174	15	a	a	DET
bptjm-64	174	16	�	�	NOUN
bptjm-64	174	17	ecting	ecte	VERB
bptjm-64	174	18	the	the	DET
bptjm-64	174	19	growth	growth	NOUN
bptjm-64	174	20	of	of	ADP
bptjm-64	174	21	leukemic	leukemic	ADJ
bptjm-64	174	22	cells	cell	NOUN
bptjm-64	174	23	.	.	PUNCT
bptjm-64	175	1	this	this	PRON
bptjm-64	175	2	suggests	suggest	VERB
bptjm-64	175	3	that	that	SCONJ
bptjm-64	175	4	lag-3	lag-3	PUNCT
bptjm-64	175	5	blockade	blockade	NOUN
bptjm-64	175	6	can	can	AUX
bptjm-64	175	7	reverse	reverse	VERB
bptjm-64	175	8	the	the	DET
bptjm-64	175	9	inhibition	inhibition	NOUN
bptjm-64	175	10	of	of	ADP
bptjm-64	175	11	nk	nk	PROPN
bptjm-64	175	12	and	and	CCONJ
bptjm-64	175	13	t	t	PROPN
bptjm-64	175	14	cells	cell	NOUN
bptjm-64	175	15	,	,	PUNCT
bptjm-64	175	16	potentially	potentially	ADV
bptjm-64	175	17	restoring	restore	VERB
bptjm-64	175	18	their	their	PRON
bptjm-64	175	19	anti	anti	ADJ
bptjm-64	175	20	-	-	ADJ
bptjm-64	175	21	leukemic	leukemic	ADJ
bptjm-64	175	22	activity	activity	NOUN
bptjm-64	175	23	.	.	PUNCT
bptjm-64	176	1	20	20	NUM
bptjm-64	176	2	berkeley	berkeley	PROPN
bptjm-64	176	3	pharma	pharma	PROPN
bptjm-64	176	4	tech	tech	NOUN
bptjm-64	176	5	journal	journal	NOUN
bptjm-64	176	6	of	of	ADP
bptjm-64	176	7	medicine	medicine	NOUN
bptjm-64	176	8	|	|	ADV
bptjm-64	176	9	135	135	NUM
bptjm-64	176	10	moreover	moreover	ADV
bptjm-64	176	11	,	,	PUNCT
bptjm-64	176	12	combining	combine	VERB
bptjm-64	176	13	relatlimab	relatlimab	NOUN
bptjm-64	176	14	with	with	ADP
bptjm-64	176	15	lenalidomide	lenalidomide	NOUN
bptjm-64	176	16	,	,	PUNCT
bptjm-64	176	17	an	an	DET
bptjm-64	176	18	angiogenesis	angiogenesis	NOUN
bptjm-64	176	19	inhibitor	inhibitor	NOUN
bptjm-64	176	20	,	,	PUNCT
bptjm-64	176	21	led	lead	VERB
bptjm-64	176	22	to	to	ADP
bptjm-64	176	23	increased	increase	VERB
bptjm-64	176	24	t	t	NOUN
bptjm-64	176	25	cell	cell	NOUN
bptjm-64	176	26	numbers	number	NOUN
bptjm-64	176	27	and	and	CCONJ
bptjm-64	176	28	enhanced	enhance	VERB
bptjm-64	176	29	anti	anti	ADJ
bptjm-64	176	30	-	-	ADJ
bptjm-64	176	31	leukemic	leukemic	ADJ
bptjm-64	176	32	activity	activity	NOUN
bptjm-64	176	33	.	.	PUNCT
bptjm-64	177	1	this	this	DET
bptjm-64	177	2	combination	combination	NOUN
bptjm-64	177	3	therapy	therapy	NOUN
bptjm-64	177	4	approach	approach	NOUN
bptjm-64	177	5	may	may	AUX
bptjm-64	177	6	o	o	PART
bptjm-64	177	7	�	�	VERB
bptjm-64	177	8	er	er	INTJ
bptjm-64	177	9	a	a	DET
bptjm-64	177	10	synergistic	synergistic	ADJ
bptjm-64	177	11	e	e	NOUN
bptjm-64	177	12	�	�	NOUN
bptjm-64	177	13	ect	ect	VERB
bptjm-64	177	14	in	in	ADP
bptjm-64	177	15	treating	treat	VERB
bptjm-64	177	16	cll	cll	PROPN
bptjm-64	177	17	by	by	ADP
bptjm-64	177	18	targeting	target	VERB
bptjm-64	177	19	both	both	DET
bptjm-64	177	20	lag-3	lag-3	ADV
bptjm-64	177	21	-	-	PUNCT
bptjm-64	177	22	mediated	mediate	VERB
bptjm-64	177	23	immune	immune	ADJ
bptjm-64	177	24	suppression	suppression	NOUN
bptjm-64	177	25	and	and	CCONJ
bptjm-64	177	26	angiogenesis	angiogenesis	NOUN
bptjm-64	177	27	.	.	PUNCT
bptjm-64	178	1	overall	overall	ADV
bptjm-64	178	2	,	,	PUNCT
bptjm-64	178	3	these	these	DET
bptjm-64	178	4	�	�	NOUN
bptjm-64	178	5	ndings	nding	NOUN
bptjm-64	178	6	provide	provide	VERB
bptjm-64	178	7	a	a	DET
bptjm-64	178	8	promising	promising	ADJ
bptjm-64	178	9	direction	direction	NOUN
bptjm-64	178	10	for	for	ADP
bptjm-64	178	11	the	the	DET
bptjm-64	178	12	development	development	NOUN
bptjm-64	178	13	of	of	ADP
bptjm-64	178	14	novel	novel	ADJ
bptjm-64	178	15	immunotherapies	immunotherapy	NOUN
bptjm-64	178	16	for	for	ADP
bptjm-64	178	17	cll	cll	PROPN
bptjm-64	178	18	,	,	PUNCT
bptjm-64	178	19	particularly	particularly	ADV
bptjm-64	178	20	for	for	ADP
bptjm-64	178	21	patients	patient	NOUN
bptjm-64	178	22	who	who	PRON
bptjm-64	178	23	have	have	AUX
bptjm-64	178	24	not	not	PART
bptjm-64	178	25	responded	respond	VERB
bptjm-64	178	26	well	well	ADV
bptjm-64	178	27	to	to	ADP
bptjm-64	178	28	pd-1	pd-1	ADJ
bptjm-64	178	29	or	or	CCONJ
bptjm-64	178	30	ctla-4	ctla-4	NOUN
bptjm-64	178	31	blockade	blockade	NOUN
bptjm-64	178	32	.	.	PUNCT
bptjm-64	179	1	20	20	NUM
bptjm-64	179	2	cancer	cancer	NOUN
bptjm-64	179	3	often	often	ADV
bptjm-64	179	4	spreads	spread	VERB
bptjm-64	179	5	to	to	ADP
bptjm-64	179	6	the	the	DET
bptjm-64	179	7	liver	liver	NOUN
bptjm-64	179	8	,	,	PUNCT
bptjm-64	179	9	complicating	complicate	VERB
bptjm-64	179	10	treatment	treatment	NOUN
bptjm-64	179	11	with	with	ADP
bptjm-64	179	12	immunotherapy	immunotherapy	NOUN
bptjm-64	179	13	.	.	PUNCT
bptjm-64	180	1	liver	liver	NOUN
bptjm-64	180	2	metastases	metastasis	NOUN
bptjm-64	180	3	attract	attract	VERB
bptjm-64	180	4	activated	activated	ADJ
bptjm-64	180	5	cd8	cd8	PROPN
bptjm-64	180	6	+	+	PROPN
bptjm-64	180	7	t	t	NOUN
bptjm-64	180	8	cells	cell	NOUN
bptjm-64	180	9	,	,	PUNCT
bptjm-64	180	10	which	which	PRON
bptjm-64	180	11	then	then	ADV
bptjm-64	180	12	undergo	undergo	VERB
bptjm-64	180	13	apoptosis	apoptosis	NOUN
bptjm-64	180	14	,	,	PUNCT
bptjm-64	180	15	resulting	result	VERB
bptjm-64	180	16	in	in	ADP
bptjm-64	180	17	a	a	DET
bptjm-64	180	18	signi	signi	ADJ
bptjm-64	180	19	�	�	NOUN
bptjm-64	180	20	cant	cant	NOUN
bptjm-64	180	21	reduction	reduction	NOUN
bptjm-64	180	22	in	in	ADP
bptjm-64	180	23	e	e	PROPN
bptjm-64	180	24	�	�	PROPN
bptjm-64	180	25	ective	ective	ADJ
bptjm-64	180	26	t	t	NOUN
bptjm-64	180	27	cells	cell	NOUN
bptjm-64	180	28	.	.	PUNCT
bptjm-64	181	1	41	41	NUM
bptjm-64	181	2	a	a	DET
bptjm-64	181	3	study	study	NOUN
bptjm-64	181	4	comparing	compare	VERB
bptjm-64	181	5	patients	patient	NOUN
bptjm-64	181	6	with	with	ADP
bptjm-64	181	7	metastatic	metastatic	ADJ
bptjm-64	181	8	melanoma	melanoma	NOUN
bptjm-64	181	9	and	and	CCONJ
bptjm-64	181	10	nsclc	nsclc	NOUN
bptjm-64	181	11	who	who	PRON
bptjm-64	181	12	received	receive	VERB
bptjm-64	181	13	immunotherapy	immunotherapy	NOUN
bptjm-64	181	14	and	and	CCONJ
bptjm-64	181	15	targeted	target	VERB
bptjm-64	181	16	therapy	therapy	NOUN
bptjm-64	181	17	,	,	PUNCT
bptjm-64	181	18	or	or	CCONJ
bptjm-64	181	19	immunotherapy	immunotherapy	NOUN
bptjm-64	181	20	and	and	CCONJ
bptjm-64	181	21	chemotherapy	chemotherapy	NOUN
bptjm-64	181	22	respectively	respectively	ADV
bptjm-64	181	23	,	,	PUNCT
bptjm-64	181	24	revealed	reveal	VERB
bptjm-64	181	25	that	that	SCONJ
bptjm-64	181	26	liver	liver	NOUN
bptjm-64	181	27	metastases	metastasis	NOUN
bptjm-64	181	28	were	be	AUX
bptjm-64	181	29	linked	link	VERB
bptjm-64	181	30	to	to	ADP
bptjm-64	181	31	reduced	reduce	VERB
bptjm-64	181	32	response	response	NOUN
bptjm-64	181	33	to	to	ADP
bptjm-64	181	34	immunotherapy	immunotherapy	NOUN
bptjm-64	181	35	but	but	CCONJ
bptjm-64	181	36	not	not	PART
bptjm-64	181	37	targeted	target	VERB
bptjm-64	181	38	therapy	therapy	NOUN
bptjm-64	181	39	.	.	PUNCT
bptjm-64	182	1	41	41	NUM
bptjm-64	182	2	similarly	similarly	ADV
bptjm-64	182	3	,	,	PUNCT
bptjm-64	182	4	in	in	ADP
bptjm-64	182	5	nsclc	nsclc	NOUN
bptjm-64	182	6	cases	case	NOUN
bptjm-64	182	7	,	,	PUNCT
bptjm-64	182	8	immunotherapy	immunotherapy	NOUN
bptjm-64	182	9	had	have	AUX
bptjm-64	182	10	limited	limit	VERB
bptjm-64	182	11	e	e	NOUN
bptjm-64	182	12	�	�	NOUN
bptjm-64	182	13	cacy	cacy	NOUN
bptjm-64	182	14	compared	compare	VERB
bptjm-64	182	15	to	to	ADP
bptjm-64	182	16	chemotherapy	chemotherapy	NOUN
bptjm-64	182	17	,	,	PUNCT
bptjm-64	182	18	while	while	SCONJ
bptjm-64	182	19	radiotherapy	radiotherapy	NOUN
bptjm-64	182	20	showed	show	VERB
bptjm-64	182	21	promising	promising	ADJ
bptjm-64	182	22	results	result	NOUN
bptjm-64	182	23	.	.	PUNCT
bptjm-64	183	1	these	these	DET
bptjm-64	183	2	�	�	PROPN
bptjm-64	183	3	ndings	nding	NOUN
bptjm-64	183	4	suggest	suggest	VERB
bptjm-64	183	5	that	that	SCONJ
bptjm-64	183	6	liver	liver	NOUN
bptjm-64	183	7	metastasis	metastasis	NOUN
bptjm-64	183	8	may	may	AUX
bptjm-64	183	9	be	be	AUX
bptjm-64	183	10	more	more	ADJ
bptjm-64	183	11	e	e	AUX
bptjm-64	183	12	�	�	NOUN
bptjm-64	183	13	ectively	ectively	ADV
bptjm-64	183	14	managed	manage	VERB
bptjm-64	183	15	through	through	ADP
bptjm-64	183	16	nonimmunotherapeutic	nonimmunotherapeutic	ADJ
bptjm-64	183	17	methods	method	NOUN
bptjm-64	183	18	,	,	PUNCT
bptjm-64	183	19	informing	inform	VERB
bptjm-64	183	20	future	future	ADJ
bptjm-64	183	21	treatment	treatment	NOUN
bptjm-64	183	22	strategies.41	strategies.41	NOUN
bptjm-64	183	23	6	6	NUM
bptjm-64	183	24	.	.	PUNCT
bptjm-64	183	25	practical	practical	ADJ
bptjm-64	183	26	applications	application	NOUN
bptjm-64	183	27	/	/	SYM
bptjm-64	183	28	discussion	discussion	NOUN
bptjm-64	183	29	numerous	numerous	ADJ
bptjm-64	183	30	innovative	innovative	ADJ
bptjm-64	183	31	combination	combination	NOUN
bptjm-64	183	32	therapies	therapy	NOUN
bptjm-64	183	33	extend	extend	VERB
bptjm-64	183	34	beyond	beyond	ADP
bptjm-64	183	35	traditional	traditional	ADJ
bptjm-64	183	36	chemotherapy	chemotherapy	NOUN
bptjm-64	183	37	and	and	CCONJ
bptjm-64	183	38	immunotherapy	immunotherapy	NOUN
bptjm-64	183	39	,	,	PUNCT
bptjm-64	183	40	delving	delve	VERB
bptjm-64	183	41	into	into	ADP
bptjm-64	183	42	the	the	DET
bptjm-64	183	43	modulation	modulation	NOUN
bptjm-64	183	44	of	of	ADP
bptjm-64	183	45	the	the	DET
bptjm-64	183	46	tumor	tumor	NOUN
bptjm-64	183	47	microenvironment	microenvironment	NOUN
bptjm-64	183	48	(	(	PUNCT
bptjm-64	183	49	tme	tme	NOUN
bptjm-64	183	50	)	)	PUNCT
bptjm-64	183	51	to	to	PART
bptjm-64	183	52	bolster	bolster	VERB
bptjm-64	183	53	immune	immune	ADJ
bptjm-64	183	54	responses	response	NOUN
bptjm-64	183	55	.	.	PUNCT
bptjm-64	184	1	for	for	ADP
bptjm-64	184	2	instance	instance	NOUN
bptjm-64	184	3	,	,	PUNCT
bptjm-64	184	4	one	one	NUM
bptjm-64	184	5	approach	approach	NOUN
bptjm-64	184	6	involves	involve	VERB
bptjm-64	184	7	delivering	deliver	VERB
bptjm-64	184	8	a	a	DET
bptjm-64	184	9	fecal	fecal	ADJ
bptjm-64	184	10	microbiota	microbiota	NOUN
bptjm-64	184	11	transplant	transplant	NOUN
bptjm-64	184	12	(	(	PUNCT
bptjm-64	184	13	fmt	fmt	NOUN
bptjm-64	184	14	)	)	PUNCT
bptjm-64	184	15	via	via	ADP
bptjm-64	184	16	colonoscopy	colonoscopy	NOUN
bptjm-64	184	17	alongside	alongside	ADP
bptjm-64	184	18	immunotherapeutic	immunotherapeutic	ADJ
bptjm-64	184	19	anti	anti	ADJ
bptjm-64	184	20	-	-	ADJ
bptjm-64	184	21	pd-1	pd-1	ADJ
bptjm-64	184	22	drugs.36	drugs.36	NOUN
bptjm-64	184	23	this	this	DET
bptjm-64	184	24	strategy	strategy	NOUN
bptjm-64	184	25	e	e	NOUN
bptjm-64	184	26	�	�	NOUN
bptjm-64	184	27	ectively	ectively	ADV
bptjm-64	184	28	reshapes	reshape	VERB
bptjm-64	184	29	the	the	DET
bptjm-64	184	30	tme	tme	PROPN
bptjm-64	184	31	,	,	PUNCT
bptjm-64	184	32	overcoming	overcome	VERB
bptjm-64	184	33	primary	primary	ADJ
bptjm-64	184	34	resistance	resistance	NOUN
bptjm-64	184	35	to	to	ADP
bptjm-64	184	36	anti	anti	NOUN
bptjm-64	184	37	-	-	NOUN
bptjm-64	184	38	pd-1	pd-1	ADJ
bptjm-64	184	39	in	in	ADP
bptjm-64	184	40	advanced	advanced	ADJ
bptjm-64	184	41	melanoma	melanoma	NOUN
bptjm-64	184	42	patients	patient	NOUN
bptjm-64	184	43	.	.	PUNCT
bptjm-64	185	1	following	follow	VERB
bptjm-64	185	2	treatment	treatment	NOUN
bptjm-64	185	3	,	,	PUNCT
bptjm-64	185	4	there	there	PRON
bptjm-64	185	5	's	be	VERB
bptjm-64	185	6	an	an	DET
bptjm-64	185	7	increase	increase	NOUN
bptjm-64	185	8	in	in	ADP
bptjm-64	185	9	the	the	DET
bptjm-64	185	10	proportion	proportion	NOUN
bptjm-64	185	11	of	of	ADP
bptjm-64	185	12	cd56+cd8+t	cd56+cd8+t	NOUN
bptjm-64	185	13	cells	cell	NOUN
bptjm-64	185	14	,	,	PUNCT
bptjm-64	185	15	indicating	indicate	VERB
bptjm-64	185	16	heightened	heightened	ADJ
bptjm-64	185	17	circulation	circulation	NOUN
bptjm-64	185	18	of	of	ADP
bptjm-64	185	19	active	active	ADJ
bptjm-64	185	20	and	and	CCONJ
bptjm-64	185	21	di	di	NOUN
bptjm-64	185	22	�	�	PROPN
bptjm-64	185	23	erentiated	erentiate	VERB
bptjm-64	185	24	cd8	cd8	PROPN
bptjm-64	185	25	+	+	PROPN
bptjm-64	185	26	t	t	NOUN
bptjm-64	185	27	cells.36	cells.36	NOUN
bptjm-64	185	28	responders	responder	NOUN
bptjm-64	185	29	exhibit	exhibit	VERB
bptjm-64	185	30	decreased	decrease	VERB
bptjm-64	185	31	levels	level	NOUN
bptjm-64	185	32	of	of	ADP
bptjm-64	185	33	certain	certain	ADJ
bptjm-64	185	34	cytokines	cytokine	NOUN
bptjm-64	185	35	and	and	CCONJ
bptjm-64	185	36	chemokines	chemokine	NOUN
bptjm-64	185	37	linked	link	VERB
bptjm-64	185	38	to	to	ADP
bptjm-64	185	39	anti	anti	ADJ
bptjm-64	185	40	-	-	ADJ
bptjm-64	185	41	pd-1	pd-1	ADJ
bptjm-64	185	42	resistance	resistance	NOUN
bptjm-64	185	43	,	,	PUNCT
bptjm-64	185	44	while	while	SCONJ
bptjm-64	185	45	biomarkers	biomarker	NOUN
bptjm-64	185	46	associated	associate	VERB
bptjm-64	185	47	with	with	ADP
bptjm-64	185	48	improved	improved	ADJ
bptjm-64	185	49	survival	survival	NOUN
bptjm-64	185	50	are	be	AUX
bptjm-64	185	51	upregulated.36	upregulated.36	NOUN
bptjm-64	185	52	notably	notably	ADV
bptjm-64	185	53	,	,	PUNCT
bptjm-64	185	54	variations	variation	NOUN
bptjm-64	185	55	in	in	ADP
bptjm-64	185	56	patient	patient	ADJ
bptjm-64	185	57	response	response	NOUN
bptjm-64	185	58	may	may	AUX
bptjm-64	185	59	occur	occur	VERB
bptjm-64	185	60	due	due	ADP
bptjm-64	185	61	to	to	ADP
bptjm-64	185	62	factors	factor	NOUN
bptjm-64	185	63	like	like	ADP
bptjm-64	185	64	tumor	tumor	NOUN
bptjm-64	185	65	immunogenicity	immunogenicity	NOUN
bptjm-64	185	66	or	or	CCONJ
bptjm-64	185	67	unsuccessful	unsuccessful	ADJ
bptjm-64	185	68	colonization	colonization	NOUN
bptjm-64	185	69	by	by	ADP
bptjm-64	185	70	berkeley	berkeley	PROPN
bptjm-64	185	71	pharma	pharma	PROPN
bptjm-64	185	72	tech	tech	NOUN
bptjm-64	185	73	journal	journal	NOUN
bptjm-64	185	74	of	of	ADP
bptjm-64	185	75	medicine	medicine	NOUN
bptjm-64	185	76	|	|	ADV
bptjm-64	185	77	136	136	NUM
bptjm-64	185	78	fmt	fmt	NOUN
bptjm-64	185	79	,	,	PUNCT
bptjm-64	185	80	necessitating	necessitate	VERB
bptjm-64	185	81	further	further	ADJ
bptjm-64	185	82	investigation	investigation	NOUN
bptjm-64	185	83	for	for	ADP
bptjm-64	185	84	its	its	PRON
bptjm-64	185	85	establishment	establishment	NOUN
bptjm-64	185	86	as	as	ADP
bptjm-64	185	87	a	a	DET
bptjm-64	185	88	standard	standard	ADJ
bptjm-64	185	89	treatment.36	treatment.36	NOUN
bptjm-64	185	90	another	another	DET
bptjm-64	185	91	method	method	NOUN
bptjm-64	185	92	,	,	PUNCT
bptjm-64	185	93	as	as	SCONJ
bptjm-64	185	94	explored	explore	VERB
bptjm-64	185	95	by	by	ADP
bptjm-64	185	96	ribas	ribas	PROPN
bptjm-64	185	97	et	et	PROPN
bptjm-64	185	98	al	al	PROPN
bptjm-64	185	99	.	.	PROPN
bptjm-64	185	100	,	,	PUNCT
bptjm-64	185	101	involves	involve	VERB
bptjm-64	185	102	combining	combine	VERB
bptjm-64	185	103	anti	anti	ADJ
bptjm-64	185	104	-	-	ADJ
bptjm-64	185	105	pd-1	pd-1	ADJ
bptjm-64	185	106	therapy	therapy	NOUN
bptjm-64	185	107	(	(	PUNCT
bptjm-64	185	108	speci	speci	X
bptjm-64	185	109	�	�	PROPN
bptjm-64	185	110	cally	cally	ADV
bptjm-64	185	111	pembrolizumab	pembrolizumab	NOUN
bptjm-64	185	112	)	)	PUNCT
bptjm-64	185	113	with	with	ADP
bptjm-64	185	114	intratumoral	intratumoral	ADJ
bptjm-64	185	115	administration	administration	NOUN
bptjm-64	185	116	of	of	ADP
bptjm-64	185	117	an	an	DET
bptjm-64	185	118	oncolytic	oncolytic	ADJ
bptjm-64	185	119	virus	virus	NOUN
bptjm-64	185	120	,	,	PUNCT
bptjm-64	185	121	such	such	ADJ
bptjm-64	185	122	as	as	ADP
bptjm-64	185	123	talimogene	talimogene	ADJ
bptjm-64	185	124	laherparepvec	laherparepvec	PROPN
bptjm-64	185	125	,	,	PUNCT
bptjm-64	185	126	in	in	ADP
bptjm-64	185	127	advanced	advanced	ADJ
bptjm-64	185	128	melanoma	melanoma	NOUN
bptjm-64	185	129	patients	patient	NOUN
bptjm-64	185	130	.	.	PUNCT
bptjm-64	186	1	initially	initially	ADV
bptjm-64	186	2	,	,	PUNCT
bptjm-64	186	3	tumor	tumor	NOUN
bptjm-64	186	4	size	size	NOUN
bptjm-64	186	5	may	may	AUX
bptjm-64	186	6	transiently	transiently	ADV
bptjm-64	186	7	increase	increase	VERB
bptjm-64	186	8	post	post	ADJ
bptjm-64	186	9	-	-	NOUN
bptjm-64	186	10	injection	injection	NOUN
bptjm-64	186	11	;	;	PUNCT
bptjm-64	186	12	however	however	ADV
bptjm-64	186	13	,	,	PUNCT
bptjm-64	186	14	this	this	DET
bptjm-64	186	15	approach	approach	NOUN
bptjm-64	186	16	boosts	boost	VERB
bptjm-64	186	17	cd8	cd8	PROPN
bptjm-64	186	18	+	+	PROPN
bptjm-64	186	19	t	t	NOUN
bptjm-64	186	20	cell	cell	NOUN
bptjm-64	186	21	in	in	ADP
bptjm-64	186	22	�	�	PROPN
bptjm-64	186	23	ltration	ltration	NOUN
bptjm-64	186	24	and	and	CCONJ
bptjm-64	186	25	peripheral	peripheral	ADJ
bptjm-64	186	26	cd4	cd4	PROPN
bptjm-64	186	27	+	+	PROPN
bptjm-64	186	28	t	t	NOUN
bptjm-64	186	29	cell	cell	NOUN
bptjm-64	186	30	presence.48	presence.48	PROPN
bptjm-64	186	31	pembrolizumab	pembrolizumab	NOUN
bptjm-64	186	32	promotes	promote	VERB
bptjm-64	186	33	the	the	DET
bptjm-64	186	34	proliferation	proliferation	NOUN
bptjm-64	186	35	of	of	ADP
bptjm-64	186	36	cd8	cd8	PROPN
bptjm-64	186	37	+	+	PROPN
bptjm-64	186	38	t	t	NOUN
bptjm-64	186	39	cells	cell	NOUN
bptjm-64	186	40	,	,	PUNCT
bptjm-64	186	41	leading	lead	VERB
bptjm-64	186	42	to	to	ADP
bptjm-64	186	43	a	a	DET
bptjm-64	186	44	comprehensive	comprehensive	ADJ
bptjm-64	186	45	shift	shift	NOUN
bptjm-64	186	46	in	in	ADP
bptjm-64	186	47	the	the	DET
bptjm-64	186	48	tme	tme	NOUN
bptjm-64	186	49	and	and	CCONJ
bptjm-64	186	50	an	an	DET
bptjm-64	186	51	augmented	augment	VERB
bptjm-64	186	52	immune	immune	ADJ
bptjm-64	186	53	response	response	NOUN
bptjm-64	186	54	compared	compare	VERB
bptjm-64	186	55	to	to	ADP
bptjm-64	186	56	anti	anti	ADJ
bptjm-64	186	57	-	-	ADJ
bptjm-64	186	58	pd-1	pd-1	ADJ
bptjm-64	186	59	therapy	therapy	NOUN
bptjm-64	186	60	alone	alone	ADV
bptjm-64	186	61	.	.	PUNCT
bptjm-64	187	1	importantly	importantly	ADV
bptjm-64	187	2	,	,	PUNCT
bptjm-64	187	3	t	t	PROPN
bptjm-64	187	4	cells	cell	NOUN
bptjm-64	187	5	expressing	express	VERB
bptjm-64	187	6	pd-1	pd-1	ADP
bptjm-64	187	7	encounter	encounter	ADJ
bptjm-64	187	8	tumor	tumor	NOUN
bptjm-64	187	9	cells	cell	NOUN
bptjm-64	187	10	expressing	express	VERB
bptjm-64	187	11	pd	pd	NOUN
bptjm-64	187	12	-	-	PUNCT
bptjm-64	187	13	l1	l1	PROPN
bptjm-64	187	14	,	,	PUNCT
bptjm-64	187	15	a	a	DET
bptjm-64	187	16	dynamic	dynamic	ADJ
bptjm-64	187	17	that	that	SCONJ
bptjm-64	187	18	,	,	PUNCT
bptjm-64	187	19	alongside	alongside	ADP
bptjm-64	187	20	pd-1	pd-1	ADP
bptjm-64	187	21	blockade	blockade	NOUN
bptjm-64	187	22	,	,	PUNCT
bptjm-64	187	23	moderates	moderate	VERB
bptjm-64	187	24	the	the	DET
bptjm-64	187	25	antitumor	antitumor	PROPN
bptjm-64	187	26	e	e	NOUN
bptjm-64	187	27	�	�	PROPN
bptjm-64	187	28	cacy	cacy	NOUN
bptjm-64	187	29	of	of	ADP
bptjm-64	187	30	the	the	DET
bptjm-64	187	31	administered	administer	VERB
bptjm-64	187	32	virus.48	virus.48	NOUN
bptjm-64	187	33	as	as	SCONJ
bptjm-64	187	34	previously	previously	ADV
bptjm-64	187	35	discussed	discuss	VERB
bptjm-64	187	36	,	,	PUNCT
bptjm-64	187	37	extensive	extensive	ADJ
bptjm-64	187	38	research	research	NOUN
bptjm-64	187	39	has	have	AUX
bptjm-64	187	40	already	already	ADV
bptjm-64	187	41	been	be	AUX
bptjm-64	187	42	conducted	conduct	VERB
bptjm-64	187	43	on	on	ADP
bptjm-64	187	44	pd-1	pd-1	ADP
bptjm-64	187	45	,	,	PUNCT
bptjm-64	187	46	pd	pd	PROPN
bptjm-64	187	47	-	-	PUNCT
bptjm-64	187	48	l1	l1	PROPN
bptjm-64	187	49	,	,	PUNCT
bptjm-64	187	50	ctla-4	ctla-4	PROPN
bptjm-64	187	51	,	,	PUNCT
bptjm-64	187	52	and	and	CCONJ
bptjm-64	187	53	vegf	vegf	PROPN
bptjm-64	187	54	/	/	SYM
bptjm-64	187	55	vegf	vegf	PROPN
bptjm-64	187	56	-	-	PUNCT
bptjm-64	187	57	a	a	NOUN
bptjm-64	187	58	as	as	ADP
bptjm-64	187	59	targets	target	NOUN
bptjm-64	187	60	for	for	ADP
bptjm-64	187	61	treating	treat	VERB
bptjm-64	187	62	various	various	ADJ
bptjm-64	187	63	cancers	cancer	NOUN
bptjm-64	187	64	.	.	PUNCT
bptjm-64	188	1	scientists	scientist	NOUN
bptjm-64	188	2	are	be	AUX
bptjm-64	188	3	now	now	ADV
bptjm-64	188	4	focusing	focus	VERB
bptjm-64	188	5	on	on	ADP
bptjm-64	188	6	identifying	identify	VERB
bptjm-64	188	7	new	new	ADJ
bptjm-64	188	8	potential	potential	ADJ
bptjm-64	188	9	biomarkers	biomarker	NOUN
bptjm-64	188	10	to	to	PART
bptjm-64	188	11	better	well	ADV
bptjm-64	188	12	predict	predict	VERB
bptjm-64	188	13	patient	patient	ADJ
bptjm-64	188	14	responses	response	NOUN
bptjm-64	188	15	to	to	ADP
bptjm-64	188	16	speci	speci	PROPN
bptjm-64	188	17	�	�	PROPN
bptjm-64	188	18	c	c	NOUN
bptjm-64	188	19	treatments	treatment	NOUN
bptjm-64	188	20	,	,	PUNCT
bptjm-64	188	21	given	give	VERB
bptjm-64	188	22	that	that	SCONJ
bptjm-64	188	23	the	the	DET
bptjm-64	188	24	existing	exist	VERB
bptjm-64	188	25	biomarkers	biomarker	NOUN
bptjm-64	188	26	are	be	AUX
bptjm-64	188	27	not	not	PART
bptjm-64	188	28	perfect	perfect	ADJ
bptjm-64	188	29	indicators	indicator	NOUN
bptjm-64	188	30	of	of	ADP
bptjm-64	188	31	a	a	DET
bptjm-64	188	32	patient	patient	NOUN
bptjm-64	188	33	’s	’s	PART
bptjm-64	188	34	response	response	NOUN
bptjm-64	188	35	to	to	ADP
bptjm-64	188	36	immune	immune	ADJ
bptjm-64	188	37	checkpoint	checkpoint	NOUN
bptjm-64	188	38	inhibitor	inhibitor	NOUN
bptjm-64	188	39	(	(	PUNCT
bptjm-64	188	40	ici	ici	PROPN
bptjm-64	188	41	)	)	PUNCT
bptjm-64	188	42	therapy.49	therapy.49	NOUN
bptjm-64	188	43	vanhersecke	vanhersecke	PROPN
bptjm-64	188	44	et	et	PROPN
bptjm-64	188	45	al	al	PROPN
bptjm-64	188	46	.	.	PROPN
bptjm-64	188	47	observed	observe	VERB
bptjm-64	188	48	that	that	SCONJ
bptjm-64	188	49	the	the	DET
bptjm-64	188	50	tertiary	tertiary	ADJ
bptjm-64	188	51	lymphoid	lymphoid	NOUN
bptjm-64	188	52	structure	structure	NOUN
bptjm-64	188	53	(	(	PUNCT
bptjm-64	188	54	tls	tls	PROPN
bptjm-64	188	55	)	)	PUNCT
bptjm-64	188	56	within	within	ADP
bptjm-64	188	57	tumors	tumor	NOUN
bptjm-64	188	58	is	be	AUX
bptjm-64	188	59	associated	associate	VERB
bptjm-64	188	60	with	with	ADP
bptjm-64	188	61	the	the	DET
bptjm-64	188	62	population	population	NOUN
bptjm-64	188	63	of	of	ADP
bptjm-64	188	64	cd8	cd8	PROPN
bptjm-64	188	65	+	+	PROPN
bptjm-64	188	66	t	t	NOUN
bptjm-64	188	67	cells	cell	NOUN
bptjm-64	188	68	.	.	PUNCT
bptjm-64	189	1	higher	high	ADJ
bptjm-64	189	2	tls	tls	PROPN
bptjm-64	189	3	densities	density	NOUN
bptjm-64	189	4	correspond	correspond	VERB
bptjm-64	189	5	to	to	ADP
bptjm-64	189	6	increased	increase	VERB
bptjm-64	189	7	densities	density	NOUN
bptjm-64	189	8	of	of	ADP
bptjm-64	189	9	cd8	cd8	PROPN
bptjm-64	189	10	+	+	PROPN
bptjm-64	189	11	t	t	NOUN
bptjm-64	189	12	cells	cell	NOUN
bptjm-64	189	13	.	.	PUNCT
bptjm-64	190	1	moreover	moreover	ADV
bptjm-64	190	2	,	,	PUNCT
bptjm-64	190	3	the	the	DET
bptjm-64	190	4	presence	presence	NOUN
bptjm-64	190	5	of	of	ADP
bptjm-64	190	6	more	more	ADV
bptjm-64	190	7	mature	mature	ADJ
bptjm-64	190	8	tls	tls	PROPN
bptjm-64	190	9	was	be	AUX
bptjm-64	190	10	linked	link	VERB
bptjm-64	190	11	to	to	ADP
bptjm-64	190	12	improved	improved	ADJ
bptjm-64	190	13	survival	survival	NOUN
bptjm-64	190	14	rates	rate	NOUN
bptjm-64	190	15	,	,	PUNCT
bptjm-64	190	16	higher	high	ADJ
bptjm-64	190	17	objective	objective	ADJ
bptjm-64	190	18	response	response	NOUN
bptjm-64	190	19	rates	rate	NOUN
bptjm-64	190	20	,	,	PUNCT
bptjm-64	190	21	and	and	CCONJ
bptjm-64	190	22	longer	long	ADJ
bptjm-64	190	23	progression	progression	NOUN
bptjm-64	190	24	-	-	PUNCT
bptjm-64	190	25	free	free	ADJ
bptjm-64	190	26	survival	survival	NOUN
bptjm-64	190	27	.	.	PUNCT
bptjm-64	191	1	notably	notably	ADV
bptjm-64	191	2	,	,	PUNCT
bptjm-64	191	3	mature	mature	ADJ
bptjm-64	191	4	tls	tls	PROPN
bptjm-64	191	5	emerged	emerge	VERB
bptjm-64	191	6	as	as	ADP
bptjm-64	191	7	the	the	DET
bptjm-64	191	8	most	most	ADV
bptjm-64	191	9	signi	signi	ADJ
bptjm-64	191	10	�	�	NOUN
bptjm-64	191	11	cant	cant	VERB
bptjm-64	191	12	predictive	predictive	ADJ
bptjm-64	191	13	factor	factor	NOUN
bptjm-64	191	14	for	for	ADP
bptjm-64	191	15	an	an	DET
bptjm-64	191	16	objective	objective	ADJ
bptjm-64	191	17	response	response	NOUN
bptjm-64	191	18	,	,	PUNCT
bptjm-64	191	19	independent	independent	ADJ
bptjm-64	191	20	of	of	ADP
bptjm-64	191	21	pd	pd	PROPN
bptjm-64	191	22	-	-	PROPN
bptjm-64	191	23	l1	l1	PROPN
bptjm-64	191	24	expression	expression	NOUN
bptjm-64	191	25	and	and	CCONJ
bptjm-64	191	26	cd8	cd8	PROPN
bptjm-64	191	27	+	+	PROPN
bptjm-64	191	28	t	t	PROPN
bptjm-64	191	29	-	-	PUNCT
bptjm-64	191	30	cell	cell	NOUN
bptjm-64	191	31	in	in	ADP
bptjm-64	191	32	�	�	PROPN
bptjm-64	191	33	ltration	ltration	NOUN
bptjm-64	191	34	.	.	PUNCT
bptjm-64	192	1	patients	patient	NOUN
bptjm-64	192	2	with	with	ADP
bptjm-64	192	3	tumors	tumor	NOUN
bptjm-64	192	4	containing	contain	VERB
bptjm-64	192	5	mature	mature	ADJ
bptjm-64	192	6	tls	tls	PROPN
bptjm-64	192	7	had	have	VERB
bptjm-64	192	8	better	well	ADJ
bptjm-64	192	9	outcomes	outcome	NOUN
bptjm-64	192	10	compared	compare	VERB
bptjm-64	192	11	to	to	ADP
bptjm-64	192	12	those	those	PRON
bptjm-64	192	13	without	without	ADP
bptjm-64	192	14	mature	mature	ADJ
bptjm-64	192	15	tls.49	tls.49	NOUN
bptjm-64	192	16	studying	study	VERB
bptjm-64	192	17	the	the	DET
bptjm-64	192	18	tls	tls	NOUN
bptjm-64	192	19	in	in	ADP
bptjm-64	192	20	tumors	tumor	NOUN
bptjm-64	192	21	opens	open	VERB
bptjm-64	192	22	a	a	DET
bptjm-64	192	23	new	new	ADJ
bptjm-64	192	24	avenue	avenue	NOUN
bptjm-64	192	25	for	for	ADP
bptjm-64	192	26	identifying	identify	VERB
bptjm-64	192	27	biomarkers	biomarker	NOUN
bptjm-64	192	28	to	to	PART
bptjm-64	192	29	predict	predict	VERB
bptjm-64	192	30	patient	patient	ADJ
bptjm-64	192	31	responses	response	NOUN
bptjm-64	192	32	to	to	ADP
bptjm-64	192	33	speci	speci	PROPN
bptjm-64	192	34	�	�	PROPN
bptjm-64	192	35	c	c	PROPN
bptjm-64	192	36	ici	ici	NOUN
bptjm-64	192	37	treatments	treatment	NOUN
bptjm-64	192	38	.	.	PUNCT
bptjm-64	193	1	two	two	NUM
bptjm-64	193	2	ongoing	ongoing	ADJ
bptjm-64	193	3	clinical	clinical	ADJ
bptjm-64	193	4	trials	trial	NOUN
bptjm-64	193	5	are	be	AUX
bptjm-64	193	6	exploring	explore	VERB
bptjm-64	193	7	recent	recent	ADJ
bptjm-64	193	8	advances	advance	NOUN
bptjm-64	193	9	in	in	ADP
bptjm-64	193	10	immunotherapy	immunotherapy	NOUN
bptjm-64	193	11	and	and	CCONJ
bptjm-64	193	12	tumor	tumor	NOUN
bptjm-64	193	13	microenvironment	microenvironment	NOUN
bptjm-64	193	14	(	(	PUNCT
bptjm-64	193	15	tme	tme	NOUN
bptjm-64	193	16	)	)	PUNCT
bptjm-64	193	17	mediated	mediate	VERB
bptjm-64	193	18	treatments	treatment	NOUN
bptjm-64	193	19	,	,	PUNCT
bptjm-64	193	20	focusing	focus	VERB
bptjm-64	193	21	on	on	ADP
bptjm-64	193	22	combination	combination	NOUN
bptjm-64	193	23	therapies	therapy	NOUN
bptjm-64	193	24	involving	involve	VERB
bptjm-64	193	25	lag-3	lag-3	ADJ
bptjm-64	193	26	,	,	PUNCT
bptjm-64	193	27	anti	anti	ADJ
bptjm-64	193	28	-	-	ADJ
bptjm-64	193	29	pd-1	pd-1	ADJ
bptjm-64	193	30	,	,	PUNCT
bptjm-64	193	31	and	and	CCONJ
bptjm-64	193	32	vegf	vegf	PROPN
bptjm-64	193	33	signaling	signaling	PROPN
bptjm-64	193	34	.	.	PUNCT
bptjm-64	194	1	berkeley	berkeley	PROPN
bptjm-64	194	2	pharma	pharma	PROPN
bptjm-64	194	3	tech	tech	PROPN
bptjm-64	194	4	journal	journal	NOUN
bptjm-64	194	5	of	of	ADP
bptjm-64	194	6	medicine	medicine	NOUN
bptjm-64	194	7	|	|	ADV
bptjm-64	194	8	137	137	NUM
bptjm-64	194	9	the	the	DET
bptjm-64	194	10	�	�	PROPN
bptjm-64	194	11	rst	rst	PROPN
bptjm-64	194	12	trial	trial	NOUN
bptjm-64	194	13	is	be	AUX
bptjm-64	194	14	investigating	investigate	VERB
bptjm-64	194	15	the	the	DET
bptjm-64	194	16	e	e	NOUN
bptjm-64	194	17	�	�	NOUN
bptjm-64	194	18	ects	ect	NOUN
bptjm-64	194	19	of	of	ADP
bptjm-64	194	20	anti	anti	NOUN
bptjm-64	194	21	-	-	NOUN
bptjm-64	194	22	lag-3	lag-3	PUNCT
bptjm-64	194	23	(	(	PUNCT
bptjm-64	194	24	urelumab	urelumab	NOUN
bptjm-64	194	25	)	)	PUNCT
bptjm-64	194	26	alone	alone	ADV
bptjm-64	194	27	and	and	CCONJ
bptjm-64	194	28	in	in	ADP
bptjm-64	194	29	combination	combination	NOUN
bptjm-64	194	30	with	with	ADP
bptjm-64	194	31	nivolumab	nivolumab	NOUN
bptjm-64	194	32	(	(	PUNCT
bptjm-64	194	33	an	an	DET
bptjm-64	194	34	anti	anti	ADJ
bptjm-64	194	35	-	-	ADJ
bptjm-64	194	36	pd-1	pd-1	ADJ
bptjm-64	194	37	drug	drug	NOUN
bptjm-64	194	38	)	)	PUNCT
bptjm-64	194	39	in	in	ADP
bptjm-64	194	40	patients	patient	NOUN
bptjm-64	194	41	with	with	ADP
bptjm-64	194	42	recurrent	recurrent	ADJ
bptjm-64	194	43	glioblastoma	glioblastoma	NOUN
bptjm-64	194	44	.	.	PUNCT
bptjm-64	195	1	the	the	DET
bptjm-64	195	2	study	study	NOUN
bptjm-64	195	3	aims	aim	VERB
bptjm-64	195	4	to	to	PART
bptjm-64	195	5	determine	determine	VERB
bptjm-64	195	6	which	which	DET
bptjm-64	195	7	treatment	treatment	NOUN
bptjm-64	195	8	regimen	regimen	NOUN
bptjm-64	195	9	is	be	AUX
bptjm-64	195	10	more	more	ADJ
bptjm-64	195	11	e	e	NOUN
bptjm-64	195	12	�	�	NOUN
bptjm-64	195	13	ective	ective	ADJ
bptjm-64	195	14	at	at	ADP
bptjm-64	195	15	killing	kill	VERB
bptjm-64	195	16	tumor	tumor	NOUN
bptjm-64	195	17	cells	cell	NOUN
bptjm-64	195	18	.	.	PUNCT
bptjm-64	196	1	currently	currently	ADV
bptjm-64	196	2	,	,	PUNCT
bptjm-64	196	3	63	63	NUM
bptjm-64	196	4	patients	patient	NOUN
bptjm-64	196	5	are	be	AUX
bptjm-64	196	6	enrolled	enrol	VERB
bptjm-64	196	7	,	,	PUNCT
bptjm-64	196	8	and	and	CCONJ
bptjm-64	196	9	the	the	DET
bptjm-64	196	10	trial	trial	NOUN
bptjm-64	196	11	is	be	AUX
bptjm-64	196	12	expected	expect	VERB
bptjm-64	196	13	to	to	PART
bptjm-64	196	14	conclude	conclude	VERB
bptjm-64	196	15	by	by	ADP
bptjm-64	196	16	november	november	PROPN
bptjm-64	196	17	2023.50	2023.50	NUM
bptjm-64	196	18	the	the	DET
bptjm-64	196	19	second	second	ADJ
bptjm-64	196	20	trial	trial	NOUN
bptjm-64	196	21	,	,	PUNCT
bptjm-64	196	22	entering	enter	VERB
bptjm-64	196	23	phase	phase	NOUN
bptjm-64	196	24	ii	ii	NOUN
bptjm-64	196	25	,	,	PUNCT
bptjm-64	196	26	is	be	AUX
bptjm-64	196	27	evaluating	evaluate	VERB
bptjm-64	196	28	the	the	DET
bptjm-64	196	29	e	e	PROPN
bptjm-64	196	30	�	�	NOUN
bptjm-64	196	31	cacy	cacy	NOUN
bptjm-64	196	32	and	and	CCONJ
bptjm-64	196	33	safety	safety	NOUN
bptjm-64	196	34	of	of	ADP
bptjm-64	196	35	a	a	DET
bptjm-64	196	36	combination	combination	NOUN
bptjm-64	196	37	of	of	ADP
bptjm-64	196	38	anti	anti	ADJ
bptjm-64	196	39	-	-	ADJ
bptjm-64	196	40	pd	pd	ADJ
bptjm-64	196	41	-	-	PUNCT
bptjm-64	196	42	l1	l1	PROPN
bptjm-64	196	43	/	/	SYM
bptjm-64	196	44	vegf	vegf	PROPN
bptjm-64	196	45	drugs	drug	NOUN
bptjm-64	196	46	with	with	ADP
bptjm-64	196	47	traditional	traditional	ADJ
bptjm-64	196	48	chemotherapy	chemotherapy	NOUN
bptjm-64	196	49	in	in	ADP
bptjm-64	196	50	treating	treat	VERB
bptjm-64	196	51	non	non	ADJ
bptjm-64	196	52	-	-	ADJ
bptjm-64	196	53	small	small	ADJ
bptjm-64	196	54	cell	cell	NOUN
bptjm-64	196	55	lung	lung	NOUN
bptjm-64	196	56	cancer	cancer	NOUN
bptjm-64	196	57	(	(	PUNCT
bptjm-64	196	58	nsclc	nsclc	NOUN
bptjm-64	196	59	)	)	PUNCT
bptjm-64	196	60	.	.	PUNCT
bptjm-64	197	1	the	the	DET
bptjm-64	197	2	primary	primary	ADJ
bptjm-64	197	3	objectives	objective	NOUN
bptjm-64	197	4	are	be	AUX
bptjm-64	197	5	to	to	PART
bptjm-64	197	6	measure	measure	VERB
bptjm-64	197	7	the	the	DET
bptjm-64	197	8	objective	objective	ADJ
bptjm-64	197	9	response	response	NOUN
bptjm-64	197	10	rate	rate	NOUN
bptjm-64	197	11	to	to	ADP
bptjm-64	197	12	the	the	DET
bptjm-64	197	13	treatment	treatment	NOUN
bptjm-64	197	14	and	and	CCONJ
bptjm-64	197	15	progression	progression	NOUN
bptjm-64	197	16	-	-	PUNCT
bptjm-64	197	17	free	free	ADJ
bptjm-64	197	18	survival	survival	NOUN
bptjm-64	197	19	,	,	PUNCT
bptjm-64	197	20	which	which	PRON
bptjm-64	197	21	involves	involve	VERB
bptjm-64	197	22	monitoring	monitor	VERB
bptjm-64	197	23	the	the	DET
bptjm-64	197	24	time	time	NOUN
bptjm-64	197	25	from	from	ADP
bptjm-64	197	26	the	the	DET
bptjm-64	197	27	start	start	NOUN
bptjm-64	197	28	of	of	ADP
bptjm-64	197	29	treatment	treatment	NOUN
bptjm-64	197	30	until	until	SCONJ
bptjm-64	197	31	the	the	DET
bptjm-64	197	32	cancer	cancer	NOUN
bptjm-64	197	33	progresses	progress	VERB
bptjm-64	197	34	or	or	CCONJ
bptjm-64	197	35	the	the	DET
bptjm-64	197	36	patient	patient	NOUN
bptjm-64	197	37	dies	die	VERB
bptjm-64	197	38	from	from	ADP
bptjm-64	197	39	any	any	DET
bptjm-64	197	40	cause.51	cause.51	NOUN
bptjm-64	197	41	other	other	ADJ
bptjm-64	197	42	monitored	monitor	VERB
bptjm-64	197	43	outcomes	outcome	NOUN
bptjm-64	197	44	include	include	VERB
bptjm-64	197	45	overall	overall	ADJ
bptjm-64	197	46	survival	survival	NOUN
bptjm-64	197	47	rate	rate	NOUN
bptjm-64	197	48	,	,	PUNCT
bptjm-64	197	49	disease	disease	NOUN
bptjm-64	197	50	control	control	NOUN
bptjm-64	197	51	,	,	PUNCT
bptjm-64	197	52	response	response	NOUN
bptjm-64	197	53	duration	duration	NOUN
bptjm-64	197	54	,	,	PUNCT
bptjm-64	197	55	treatment	treatment	NOUN
bptjm-64	197	56	-	-	PUNCT
bptjm-64	197	57	related	relate	VERB
bptjm-64	197	58	adverse	adverse	ADJ
bptjm-64	197	59	events	event	NOUN
bptjm-64	197	60	,	,	PUNCT
bptjm-64	197	61	and	and	CCONJ
bptjm-64	197	62	the	the	DET
bptjm-64	197	63	correlation	correlation	NOUN
bptjm-64	197	64	between	between	ADP
bptjm-64	197	65	pd	pd	PROPN
bptjm-64	197	66	-	-	PUNCT
bptjm-64	197	67	l1	l1	PROPN
bptjm-64	197	68	expression	expression	NOUN
bptjm-64	197	69	and	and	CCONJ
bptjm-64	197	70	antitumor	antitumor	PROPN
bptjm-64	197	71	e	e	NOUN
bptjm-64	197	72	�	�	PROPN
bptjm-64	197	73	ect	ect	NOUN
bptjm-64	197	74	.	.	PUNCT
bptjm-64	198	1	the	the	DET
bptjm-64	198	2	clinical	clinical	ADJ
bptjm-64	198	3	trial	trial	NOUN
bptjm-64	198	4	aims	aim	VERB
bptjm-64	198	5	to	to	PART
bptjm-64	198	6	enroll	enroll	VERB
bptjm-64	198	7	374	374	NUM
bptjm-64	198	8	patients	patient	NOUN
bptjm-64	198	9	and	and	CCONJ
bptjm-64	198	10	is	be	AUX
bptjm-64	198	11	expected	expect	VERB
bptjm-64	198	12	to	to	PART
bptjm-64	198	13	be	be	AUX
bptjm-64	198	14	completed	complete	VERB
bptjm-64	198	15	by	by	ADP
bptjm-64	198	16	december	december	PROPN
bptjm-64	198	17	2025.51	2025.51	NUM
bptjm-64	198	18	7	7	NUM
bptjm-64	198	19	.	.	PUNCT
bptjm-64	199	1	conclusion	conclusion	VERB
bptjm-64	199	2	the	the	DET
bptjm-64	199	3	tumor	tumor	NOUN
bptjm-64	199	4	microenvironment	microenvironment	NOUN
bptjm-64	199	5	(	(	PUNCT
bptjm-64	199	6	tme	tme	NOUN
bptjm-64	199	7	)	)	PUNCT
bptjm-64	199	8	is	be	AUX
bptjm-64	199	9	a	a	DET
bptjm-64	199	10	promising	promising	ADJ
bptjm-64	199	11	target	target	NOUN
bptjm-64	199	12	in	in	ADP
bptjm-64	199	13	immunotherapy	immunotherapy	NOUN
bptjm-64	199	14	.	.	PUNCT
bptjm-64	200	1	due	due	ADP
bptjm-64	200	2	to	to	ADP
bptjm-64	200	3	its	its	PRON
bptjm-64	200	4	variability	variability	NOUN
bptjm-64	200	5	and	and	CCONJ
bptjm-64	200	6	adaptability	adaptability	NOUN
bptjm-64	200	7	,	,	PUNCT
bptjm-64	200	8	further	further	ADJ
bptjm-64	200	9	research	research	NOUN
bptjm-64	200	10	is	be	AUX
bptjm-64	200	11	needed	need	VERB
bptjm-64	200	12	to	to	PART
bptjm-64	200	13	e	e	VERB
bptjm-64	200	14	�	�	NOUN
bptjm-64	200	15	ectively	ectively	ADV
bptjm-64	200	16	target	target	VERB
bptjm-64	200	17	di	di	NOUN
bptjm-64	200	18	�	�	PROPN
bptjm-64	200	19	erent	erent	NOUN
bptjm-64	200	20	tme	tme	NOUN
bptjm-64	200	21	components	component	NOUN
bptjm-64	200	22	.	.	PUNCT
bptjm-64	201	1	current	current	ADJ
bptjm-64	201	2	techniques	technique	NOUN
bptjm-64	201	3	include	include	VERB
bptjm-64	201	4	immune	immune	ADJ
bptjm-64	201	5	checkpoint	checkpoint	NOUN
bptjm-64	201	6	blockades	blockade	NOUN
bptjm-64	201	7	like	like	ADP
bptjm-64	201	8	pd-1	pd-1	ADP
bptjm-64	201	9	and	and	CCONJ
bptjm-64	201	10	ctla-4	ctla-4	NUM
bptjm-64	201	11	,	,	PUNCT
bptjm-64	201	12	and	and	CCONJ
bptjm-64	201	13	targeting	target	VERB
bptjm-64	201	14	lactic	lactic	ADJ
bptjm-64	201	15	acid	acid	NOUN
bptjm-64	201	16	and	and	CCONJ
bptjm-64	201	17	metabolism	metabolism	NOUN
bptjm-64	201	18	.	.	PUNCT
bptjm-64	202	1	future	future	ADJ
bptjm-64	202	2	prospects	prospect	NOUN
bptjm-64	202	3	lie	lie	VERB
bptjm-64	202	4	in	in	ADP
bptjm-64	202	5	combination	combination	NOUN
bptjm-64	202	6	therapies	therapy	NOUN
bptjm-64	202	7	with	with	ADP
bptjm-64	202	8	chemotherapy	chemotherapy	NOUN
bptjm-64	202	9	or	or	CCONJ
bptjm-64	202	10	neoadjuvant	neoadjuvant	ADJ
bptjm-64	202	11	therapy	therapy	NOUN
bptjm-64	202	12	,	,	PUNCT
bptjm-64	202	13	microbiota	microbiota	NOUN
bptjm-64	202	14	fecal	fecal	ADJ
bptjm-64	202	15	transplants	transplant	NOUN
bptjm-64	202	16	to	to	PART
bptjm-64	202	17	enhance	enhance	VERB
bptjm-64	202	18	tme	tme	NOUN
bptjm-64	202	19	for	for	ADP
bptjm-64	202	20	therapy	therapy	NOUN
bptjm-64	202	21	,	,	PUNCT
bptjm-64	202	22	classifying	classify	VERB
bptjm-64	202	23	cpr	cpr	PROPN
bptjm-64	202	24	versus	versus	ADP
bptjm-64	202	25	non	non	ADJ
bptjm-64	202	26	-	-	ADJ
bptjm-64	202	27	cpr	cpr	ADJ
bptjm-64	202	28	tumors	tumor	NOUN
bptjm-64	202	29	,	,	PUNCT
bptjm-64	202	30	and	and	CCONJ
bptjm-64	202	31	optimizing	optimize	VERB
bptjm-64	202	32	the	the	DET
bptjm-64	202	33	timing	timing	NOUN
bptjm-64	202	34	of	of	ADP
bptjm-64	202	35	immunotherapy	immunotherapy	NOUN
bptjm-64	202	36	in	in	ADP
bptjm-64	202	37	combination	combination	NOUN
bptjm-64	202	38	treatments.36	treatments.36	ADJ
bptjm-64	202	39	berkeley	berkeley	PROPN
bptjm-64	202	40	pharma	pharma	PROPN
bptjm-64	202	41	tech	tech	NOUN
bptjm-64	202	42	journal	journal	NOUN
bptjm-64	202	43	of	of	ADP
bptjm-64	202	44	medicine	medicine	NOUN
bptjm-64	202	45	|	|	ADV
bptjm-64	202	46	138	138	NUM
bptjm-64	202	47	references	reference	NOUN
bptjm-64	202	48	1	1	NUM
bptjm-64	202	49	.	.	PUNCT
bptjm-64	202	50	jung	jung	PROPN
bptjm-64	202	51	jg	jg	PROPN
bptjm-64	202	52	,	,	PUNCT
bptjm-64	202	53	le	le	AUX
bptjm-64	202	54	a.	a.	NOUN
bptjm-64	202	55	targeting	target	VERB
bptjm-64	202	56	metabolic	metabolic	NOUN
bptjm-64	202	57	cross	cross	NOUN
bptjm-64	202	58	talk	talk	NOUN
bptjm-64	202	59	between	between	ADP
bptjm-64	202	60	cancer	cancer	NOUN
bptjm-64	202	61	cells	cell	NOUN
bptjm-64	202	62	and	and	CCONJ
bptjm-64	202	63	cancer	cancer	NOUN
bptjm-64	202	64	-	-	PUNCT
bptjm-64	202	65	associated	associate	VERB
bptjm-64	202	66	�	�	NOUN
bptjm-64	202	67	broblasts	broblast	NOUN
bptjm-64	202	68	.	.	PUNCT
bptjm-64	203	1	springerlink	springerlink	NOUN
bptjm-64	203	2	.	.	PUNCT
bptjm-64	204	1	january	january	PROPN
bptjm-64	204	2	1	1	NUM
bptjm-64	204	3	,	,	PUNCT
bptjm-64	204	4	1970	1970	NUM
bptjm-64	204	5	.	.	PUNCT
bptjm-64	205	1	https://link.springer.com/chapter/10.1007/97	https://link.springer.com/chapter/10.1007/97	ADJ
bptjm-64	205	2	8	8	NUM
bptjm-64	205	3	-	-	SYM
bptjm-64	205	4	3	3	NUM
bptjm-64	205	5	-	-	PUNCT
bptjm-64	205	6	030	030	NUM
bptjm-64	205	7	-	-	PUNCT
bptjm-64	205	8	65768	65768	NUM
bptjm-64	205	9	-	-	PUNCT
bptjm-64	205	10	0_15	0_15	NUM
bptjm-64	205	11	.	.	PUNCT
bptjm-64	206	1	2	2	NUM
bptjm-64	206	2	.	.	X
bptjm-64	206	3	sadeghi	sadeghi	PROPN
bptjm-64	206	4	rad	rad	PROPN
bptjm-64	206	5	h	h	PROPN
bptjm-64	206	6	,	,	PUNCT
bptjm-64	206	7	monkman	monkman	PROPN
bptjm-64	206	8	j	j	PROPN
bptjm-64	206	9	,	,	PUNCT
bptjm-64	206	10	warkiani	warkiani	VERB
bptjm-64	206	11	me	i	PRON
bptjm-64	206	12	,	,	PUNCT
bptjm-64	206	13	et	et	PROPN
bptjm-64	206	14	al	al	PROPN
bptjm-64	206	15	.	.	PUNCT
bptjm-64	207	1	understanding	understand	VERB
bptjm-64	207	2	the	the	DET
bptjm-64	207	3	tumor	tumor	NOUN
bptjm-64	207	4	microenvironment	microenvironment	NOUN
bptjm-64	207	5	for	for	ADP
bptjm-64	207	6	e	e	NOUN
bptjm-64	207	7	�	�	NOUN
bptjm-64	207	8	ective	ective	ADJ
bptjm-64	207	9	immunotherapy	immunotherapy	NOUN
bptjm-64	207	10	.	.	PUNCT
bptjm-64	208	1	medicinal	medicinal	ADJ
bptjm-64	208	2	research	research	NOUN
bptjm-64	208	3	reviews	review	NOUN
bptjm-64	208	4	.	.	PUNCT
bptjm-64	209	1	2020;41(3):1474	2020;41(3):1474	NUM
bptjm-64	209	2	-	-	SYM
bptjm-64	209	3	1498	1498	NUM
bptjm-64	209	4	.	.	PUNCT
bptjm-64	210	1	doi:10.1002	doi:10.1002	NOUN
bptjm-64	210	2	/	/	SYM
bptjm-64	210	3	med.21765	med.21765	PROPN
bptjm-64	210	4	3	3	NUM
bptjm-64	210	5	.	.	PUNCT
bptjm-64	210	6	dobosz	dobosz	NOUN
bptjm-64	210	7	p	p	NOUN
bptjm-64	210	8	,	,	PUNCT
bptjm-64	210	9	dzieciątkowski	dzieciątkowski	ADJ
bptjm-64	210	10	t.	t.	NOUN
bptjm-64	210	11	the	the	DET
bptjm-64	210	12	intriguing	intriguing	ADJ
bptjm-64	210	13	history	history	NOUN
bptjm-64	210	14	of	of	ADP
bptjm-64	210	15	cancer	cancer	NOUN
bptjm-64	210	16	immunotherapy	immunotherapy	NOUN
bptjm-64	210	17	.	.	PUNCT
bptjm-64	211	1	frontiers	frontier	NOUN
bptjm-64	211	2	.	.	PUNCT
bptjm-64	212	1	december	december	PROPN
bptjm-64	212	2	3	3	NUM
bptjm-64	212	3	,	,	PUNCT
bptjm-64	212	4	2019	2019	NUM
bptjm-64	212	5	.	.	PUNCT
bptjm-64	213	1	https://www.frontiersin.org/articles/10.3389/f	https://www.frontiersin.org/articles/10.3389/f	PROPN
bptjm-64	213	2	immu.2019.02965	immu.2019.02965	PROPN
bptjm-64	213	3	/	/	SYM
bptjm-64	213	4	full	full	ADJ
bptjm-64	213	5	.	.	PUNCT
bptjm-64	214	1	4	4	X
bptjm-64	214	2	.	.	X
bptjm-64	214	3	yaqi	yaqi	PROPN
bptjm-64	214	4	li	li	PROPN
bptjm-64	214	5	,	,	PUNCT
bptjm-64	214	6	jing	jing	PROPN
bptjm-64	214	7	liu	liu	PROPN
bptjm-64	214	8	,	,	PUNCT
bptjm-64	214	9	long	long	ADV
bptjm-64	214	10	gao	gao	PROPN
bptjm-64	214	11	,	,	PUNCT
bptjm-64	214	12	yuan	yuan	PROPN
bptjm-64	214	13	liu	liu	PROPN
bptjm-64	214	14	,	,	PUNCT
bptjm-64	214	15	fang	fang	PROPN
bptjm-64	214	16	meng	meng	PROPN
bptjm-64	214	17	,	,	PUNCT
bptjm-64	214	18	xiaoan	xiaoan	PROPN
bptjm-64	214	19	li	li	PROPN
bptjm-64	214	20	,	,	PUNCT
bptjm-64	214	21	f.	f.	PROPN
bptjm-64	214	22	xiao	xiao	PROPN
bptjm-64	214	23	-	-	PUNCT
bptjm-64	214	24	feng	feng	PROPN
bptjm-64	214	25	qin	qin	PROPN
bptjm-64	214	26	,	,	PUNCT
bptjm-64	214	27	targeting	target	VERB
bptjm-64	214	28	the	the	DET
bptjm-64	214	29	tumor	tumor	NOUN
bptjm-64	214	30	microenvironment	microenvironment	NOUN
bptjm-64	214	31	to	to	PART
bptjm-64	214	32	overcome	overcome	VERB
bptjm-64	214	33	immune	immune	ADJ
bptjm-64	214	34	checkpoint	checkpoint	NOUN
bptjm-64	214	35	blockade	blockade	NOUN
bptjm-64	214	36	therapy	therapy	NOUN
bptjm-64	214	37	resistance	resistance	NOUN
bptjm-64	214	38	,	,	PUNCT
bptjm-64	214	39	immunology	immunology	NOUN
bptjm-64	214	40	letters	letter	NOUN
bptjm-64	214	41	,	,	PUNCT
bptjm-64	214	42	volume	volume	NOUN
bptjm-64	214	43	220	220	NUM
bptjm-64	214	44	,	,	PUNCT
bptjm-64	214	45	2020	2020	NUM
bptjm-64	214	46	,	,	PUNCT
bptjm-64	214	47	pages	page	NOUN
bptjm-64	214	48	88	88	NUM
bptjm-64	214	49	-	-	SYM
bptjm-64	214	50	96	96	NUM
bptjm-64	214	51	,	,	PUNCT
bptjm-64	214	52	issn	issn	PROPN
bptjm-64	214	53	0165	0165	NUM
bptjm-64	214	54	-	-	SYM
bptjm-64	214	55	2478	2478	NUM
bptjm-64	214	56	,	,	PUNCT
bptjm-64	214	57	https://doi.org/10.1016/j.imlet.2019.03.006	https://doi.org/10.1016/j.imlet.2019.03.006	NOUN
bptjm-64	214	58	.	.	PROPN
bptjm-64	215	1	5	5	NUM
bptjm-64	215	2	.	.	X
bptjm-64	215	3	bader	bader	PROPN
bptjm-64	215	4	je	je	PROPN
bptjm-64	215	5	,	,	PUNCT
bptjm-64	215	6	voss	voss	PROPN
bptjm-64	215	7	k	k	PROPN
bptjm-64	215	8	,	,	PUNCT
bptjm-64	215	9	rathmell	rathmell	PROPN
bptjm-64	215	10	jc	jc	PROPN
bptjm-64	215	11	.	.	PUNCT
bptjm-64	215	12	targeting	target	VERB
bptjm-64	215	13	metabolism	metabolism	NOUN
bptjm-64	215	14	to	to	PART
bptjm-64	215	15	improve	improve	VERB
bptjm-64	215	16	the	the	DET
bptjm-64	215	17	tumor	tumor	NOUN
bptjm-64	215	18	microenvironment	microenvironment	NOUN
bptjm-64	215	19	for	for	ADP
bptjm-64	215	20	cancer	cancer	NOUN
bptjm-64	215	21	immunotherapy	immunotherapy	NOUN
bptjm-64	215	22	.	.	PUNCT
bptjm-64	216	1	mol	mol	ADP
bptjm-64	216	2	cell	cell	NOUN
bptjm-64	216	3	.	.	PUNCT
bptjm-64	217	1	2020;78(6):1019	2020;78(6):1019	NUM
bptjm-64	217	2	-	-	SYM
bptjm-64	217	3	1033	1033	NUM
bptjm-64	217	4	.	.	PUNCT
bptjm-64	218	1	doi:10.1016	doi:10.1016	PROPN
bptjm-64	218	2	/	/	SYM
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bptjm-64	219	2	.	.	PUNCT
bptjm-64	219	3	cappellesso	cappellesso	PROPN
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bptjm-64	219	5	,	,	PUNCT
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bptjm-64	219	8	,	,	PUNCT
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bptjm-64	219	10	n	n	CCONJ
bptjm-64	219	11	,	,	PUNCT
bptjm-64	219	12	et	et	PROPN
bptjm-64	219	13	al	al	PROPN
bptjm-64	219	14	.	.	PUNCT
bptjm-64	220	1	targeting	target	VERB
bptjm-64	220	2	the	the	DET
bptjm-64	220	3	bicarbonate	bicarbonate	NOUN
bptjm-64	220	4	transporter	transporter	NOUN
bptjm-64	220	5	slc4a4	slc4a4	NOUN
bptjm-64	220	6	overcomes	overcome	VERB
bptjm-64	220	7	immunosuppression	immunosuppression	NOUN
bptjm-64	220	8	and	and	CCONJ
bptjm-64	220	9	immunotherapy	immunotherapy	NOUN
bptjm-64	220	10	resistance	resistance	NOUN
bptjm-64	220	11	in	in	ADP
bptjm-64	220	12	pancreatic	pancreatic	ADJ
bptjm-64	220	13	cancer	cancer	NOUN
bptjm-64	220	14	.	.	PUNCT
bptjm-64	221	1	nat	nat	NOUN
bptjm-64	221	2	cancer	cancer	NOUN
bptjm-64	221	3	.	.	PUNCT
bptjm-64	222	1	2022;3(12):1464	2022;3(12):1464	NUM
bptjm-64	222	2	-	-	SYM
bptjm-64	222	3	1483	1483	NUM
bptjm-64	222	4	.	.	PUNCT
bptjm-64	223	1	doi:10.1038	doi:10.1038	NOUN
bptjm-64	223	2	/	/	SYM
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bptjm-64	223	4	-	-	PUNCT
bptjm-64	223	5	022	022	NUM
bptjm-64	223	6	-	-	PUNCT
bptjm-64	223	7	00470	00470	NUM
bptjm-64	223	8	-	-	SYM
bptjm-64	223	9	2	2	NUM
bptjm-64	223	10	7	7	NUM
bptjm-64	223	11	.	.	PUNCT
bptjm-64	224	1	wang	wang	PROPN
bptjm-64	224	2	jx	jx	PROPN
bptjm-64	224	3	,	,	PUNCT
bptjm-64	224	4	choi	choi	PROPN
bptjm-64	224	5	syc	syc	PROPN
bptjm-64	224	6	,	,	PUNCT
bptjm-64	224	7	niu	niu	PROPN
bptjm-64	224	8	x	x	PROPN
bptjm-64	224	9	,	,	PUNCT
bptjm-64	224	10	et	et	PROPN
bptjm-64	224	11	al	al	PROPN
bptjm-64	224	12	.	.	PROPN
bptjm-64	224	13	lactic	lactic	ADJ
bptjm-64	224	14	acid	acid	NOUN
bptjm-64	224	15	and	and	CCONJ
bptjm-64	224	16	an	an	DET
bptjm-64	224	17	acidic	acidic	ADJ
bptjm-64	224	18	tumor	tumor	NOUN
bptjm-64	224	19	microenvironment	microenvironment	NOUN
bptjm-64	224	20	suppress	suppress	ADJ
bptjm-64	224	21	anticancer	anticancer	NOUN
bptjm-64	224	22	immunity	immunity	NOUN
bptjm-64	224	23	.	.	PUNCT
bptjm-64	225	1	int	int	PROPN
bptjm-64	225	2	j	j	PROPN
bptjm-64	225	3	mol	mol	ADP
bptjm-64	225	4	sci	sci	PROPN
bptjm-64	225	5	.	.	PUNCT
bptjm-64	226	1	2020;21(21):8363	2020;21(21):8363	X
bptjm-64	226	2	.	.	PUNCT
bptjm-64	227	1	doi:10.3390	doi:10.3390	NOUN
bptjm-64	227	2	/	/	SYM
bptjm-64	227	3	ijms21218363	ijms21218363	PROPN
bptjm-64	227	4	8	8	NUM
bptjm-64	227	5	.	.	PUNCT
bptjm-64	228	1	anderson	anderson	PROPN
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bptjm-64	228	6	.	.	PUNCT
bptjm-64	229	1	the	the	DET
bptjm-64	229	2	tumor	tumor	NOUN
bptjm-64	229	3	microenvironment	microenvironment	NOUN
bptjm-64	229	4	.	.	PUNCT
bptjm-64	230	1	cb	cb	AUX
bptjm-64	230	2	.	.	PROPN
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bptjm-64	230	4	9	9	NUM
bptjm-64	230	5	.	.	PUNCT
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bptjm-64	230	11	,	,	PUNCT
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bptjm-64	230	13	ms	ms	PROPN
bptjm-64	230	14	,	,	PUNCT
bptjm-64	230	15	et	et	PROPN
bptjm-64	230	16	al	al	PROPN
bptjm-64	230	17	.	.	PROPN
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bptjm-64	230	19	cellular	cellular	ADJ
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bptjm-64	230	23	pathways	pathway	NOUN
bptjm-64	230	24	in	in	ADP
bptjm-64	230	25	the	the	DET
bptjm-64	230	26	tumor	tumor	NOUN
bptjm-64	230	27	microenvironment	microenvironment	NOUN
bptjm-64	230	28	.	.	PUNCT
bptjm-64	231	1	seminars	seminar	NOUN
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bptjm-64	231	5	.	.	PUNCT
bptjm-64	232	1	august	august	PROPN
bptjm-64	232	2	18	18	NUM
bptjm-64	232	3	,	,	PUNCT
bptjm-64	232	4	2022	2022	NUM
bptjm-64	232	5	.	.	PUNCT
bptjm-64	233	1	https://www.sciencedirect.com/science/article/abs/	https://www.sciencedirect.com/science/article/abs/	PRON
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bptjm-64	233	3	/	/	SYM
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bptjm-64	235	1	kazama	kazama	PROPN
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bptjm-64	235	5	j	j	PROPN
bptjm-64	235	6	,	,	PUNCT
bptjm-64	235	7	satoyoshi	satoyoshi	PROPN
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bptjm-64	235	10	et	et	PROPN
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bptjm-64	235	16	t	t	PROPN
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bptjm-64	235	24	-	-	PUNCT
bptjm-64	235	25	cells	cell	NOUN
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bptjm-64	235	30	lymph	lymph	NOUN
bptjm-64	235	31	nodes	node	NOUN
bptjm-64	235	32	of	of	ADP
bptjm-64	235	33	colorectal	colorectal	ADJ
bptjm-64	235	34	cancer	cancer	NOUN
bptjm-64	235	35	patients	patient	NOUN
bptjm-64	235	36	.	.	PUNCT
bptjm-64	236	1	in	in	ADP
bptjm-64	236	2	vivo	vivo	NOUN
bptjm-64	236	3	.	.	PUNCT
bptjm-64	237	1	march	march	PROPN
bptjm-64	237	2	1	1	NUM
bptjm-64	237	3	,	,	PUNCT
bptjm-64	237	4	2020	2020	NUM
bptjm-64	237	5	.	.	PUNCT
bptjm-64	238	1	https://iv.iiarjournals.org/content/34/2/849	https://iv.iiarjournals.org/content/34/2/849	NOUN
bptjm-64	238	2	.	.	PUNCT
bptjm-64	239	1	11	11	NUM
bptjm-64	239	2	.	.	PUNCT
bptjm-64	240	1	hien	hien	PROPN
bptjm-64	240	2	tt	tt	PROPN
bptjm-64	240	3	,	,	PUNCT
bptjm-64	240	4	e	e	PROPN
bptjm-64	240	5	�	�	PROPN
bptjm-64	240	6	erth	erth	PROPN
bptjm-64	240	7	t	t	PROPN
bptjm-64	240	8	,	,	PUNCT
bptjm-64	240	9	kawasaki	kawasaki	PROPN
bptjm-64	240	10	j	j	PROPN
bptjm-64	240	11	,	,	PUNCT
bptjm-64	240	12	et	et	PROPN
bptjm-64	240	13	al	al	PROPN
bptjm-64	240	14	.	.	PROPN
bptjm-64	240	15	inhibition	inhibition	NOUN
bptjm-64	240	16	of	of	ADP
bptjm-64	240	17	human	human	ADJ
bptjm-64	240	18	cancer	cancer	NOUN
bptjm-64	240	19	cell	cell	NOUN
bptjm-64	240	20	line	line	NOUN
bptjm-64	240	21	growth	growth	NOUN
bptjm-64	240	22	and	and	CCONJ
bptjm-64	240	23	human	human	ADJ
bptjm-64	240	24	umbilical	umbilical	ADJ
bptjm-64	240	25	vein	vein	ADJ
bptjm-64	240	26	endothelial	endothelial	ADJ
bptjm-64	240	27	cell	cell	NOUN
bptjm-64	240	28	angiogenesis	angiogenesis	NOUN
bptjm-64	240	29	by	by	ADP
bptjm-64	240	30	artemisinin	artemisinin	NOUN
bptjm-64	240	31	derivatives	derivative	NOUN
bptjm-64	240	32	in	in	ADP
bptjm-64	240	33	vitro	vitro	VERB
bptjm-64	240	34	.	.	PUNCT
bptjm-64	241	1	pharmacological	pharmacological	ADJ
bptjm-64	241	2	research	research	NOUN
bptjm-64	241	3	.	.	PUNCT
bptjm-64	242	1	june	june	PROPN
bptjm-64	242	2	4	4	NUM
bptjm-64	242	3	,	,	PUNCT
bptjm-64	242	4	2003	2003	NUM
bptjm-64	242	5	.	.	PUNCT
bptjm-64	243	1	https://www.sciencedirect.com/science/article/abs/	https://www.sciencedirect.com/science/article/abs/	PRON
bptjm-64	243	2	pii	pii	PROPN
bptjm-64	243	3	/	/	SYM
bptjm-64	243	4	s1043661803001075?via%	s1043661803001075?via%	PROPN
bptjm-64	243	5	3dihub	3dihub	NUM
bptjm-64	243	6	.	.	PROPN
bptjm-64	243	7	12	12	NUM
bptjm-64	243	8	.	.	PUNCT
bptjm-64	244	1	felix	felix	PROPN
bptjm-64	244	2	peix	peix	PROPN
bptjm-64	244	3	,	,	PUNCT
bptjm-64	244	4	oriol	oriol	PROPN
bptjm-64	244	5	casanovas	casanovas	PROPN
bptjm-64	244	6	,	,	PUNCT
bptjm-64	244	7	promalignant	promalignant	NOUN
bptjm-64	244	8	e	e	NOUN
bptjm-64	244	9	�	�	NOUN
bptjm-64	244	10	ects	ect	NOUN
bptjm-64	244	11	of	of	ADP
bptjm-64	244	12	antiangiogenics	antiangiogenic	NOUN
bptjm-64	244	13	in	in	ADP
bptjm-64	244	14	the	the	DET
bptjm-64	244	15	tumor	tumor	NOUN
bptjm-64	244	16	microenvironment	microenvironment	NOUN
bptjm-64	244	17	,	,	PUNCT
bptjm-64	244	18	seminars	seminar	NOUN
bptjm-64	244	19	in	in	ADP
bptjm-64	244	20	cancer	cancer	NOUN
bptjm-64	244	21	biology	biology	NOUN
bptjm-64	244	22	,	,	PUNCT
bptjm-64	244	23	volume	volume	NOUN
bptjm-64	244	24	86	86	NUM
bptjm-64	244	25	,	,	PUNCT
bptjm-64	244	26	part	part	NOUN
bptjm-64	244	27	3	3	NUM
bptjm-64	244	28	,	,	PUNCT
bptjm-64	244	29	2022	2022	NUM
bptjm-64	244	30	,	,	PUNCT
bptjm-64	244	31	pages	page	VERB
bptjm-64	244	32	199	199	NUM
bptjm-64	244	33	-	-	SYM
bptjm-64	244	34	206	206	NUM
bptjm-64	244	35	,	,	PUNCT
bptjm-64	244	36	issn	issn	PROPN
bptjm-64	244	37	1044	1044	NUM
bptjm-64	244	38	-	-	PUNCT
bptjm-64	244	39	579x	579x	PROPN
bptjm-64	244	40	,	,	PUNCT
bptjm-64	244	41	https://doi.org/10.1016/j.semcancer.2022.03.003	https://doi.org/10.1016/j.semcancer.2022.03.003	NOUN
bptjm-64	244	42	13	13	NUM
bptjm-64	244	43	.	.	PUNCT
bptjm-64	245	1	li	li	PROPN
bptjm-64	245	2	y	y	PROPN
bptjm-64	245	3	,	,	PUNCT
bptjm-64	245	4	liu	liu	PROPN
bptjm-64	245	5	j	j	PROPN
bptjm-64	245	6	,	,	PUNCT
bptjm-64	245	7	gao	gao	PROPN
bptjm-64	245	8	l	l	PROPN
bptjm-64	245	9	,	,	PUNCT
bptjm-64	245	10	et	et	PROPN
bptjm-64	245	11	al	al	PROPN
bptjm-64	245	12	.	.	PUNCT
bptjm-64	245	13	targeting	target	VERB
bptjm-64	245	14	the	the	DET
bptjm-64	245	15	tumor	tumor	NOUN
bptjm-64	245	16	microenvironment	microenvironment	NOUN
bptjm-64	245	17	to	to	PART
bptjm-64	245	18	overcome	overcome	VERB
bptjm-64	245	19	immune	immune	ADJ
bptjm-64	245	20	checkpoint	checkpoint	NOUN
bptjm-64	245	21	blockade	blockade	NOUN
bptjm-64	245	22	therapy	therapy	NOUN
bptjm-64	245	23	resistance	resistance	NOUN
bptjm-64	245	24	.	.	PUNCT
bptjm-64	246	1	immunology	immunology	NOUN
bptjm-64	246	2	letters	letter	NOUN
bptjm-64	246	3	.	.	PUNCT
bptjm-64	247	1	2020;220:88	2020;220:88	NUM
bptjm-64	247	2	-	-	SYM
bptjm-64	247	3	96	96	NUM
bptjm-64	247	4	.	.	PUNCT
bptjm-64	247	5	doi:10.1016	doi:10.1016	PROPN
bptjm-64	247	6	/	/	SYM
bptjm-64	247	7	j.imlet.2019.03.006	j.imlet.2019.03.006	PROPN
bptjm-64	247	8	berkeley	berkeley	PROPN
bptjm-64	247	9	pharma	pharma	PROPN
bptjm-64	247	10	tech	tech	NOUN
bptjm-64	247	11	journal	journal	NOUN
bptjm-64	247	12	of	of	ADP
bptjm-64	247	13	medicine	medicine	NOUN
bptjm-64	247	14	|	|	ADV
bptjm-64	247	15	139	139	NUM
bptjm-64	247	16	14	14	NUM
bptjm-64	247	17	.	.	PUNCT
bptjm-64	248	1	bagchi	bagchi	PROPN
bptjm-64	248	2	s	s	PROPN
bptjm-64	248	3	,	,	PUNCT
bptjm-64	248	4	yuan	yuan	NOUN
bptjm-64	248	5	r	r	NOUN
bptjm-64	248	6	,	,	PUNCT
bptjm-64	248	7	engleman	engleman	ADJ
bptjm-64	248	8	eg	eg	NOUN
bptjm-64	248	9	.	.	PROPN
bptjm-64	249	1	immune	immune	ADJ
bptjm-64	249	2	checkpoint	checkpoint	NOUN
bptjm-64	249	3	inhibitors	inhibitor	NOUN
bptjm-64	249	4	for	for	ADP
bptjm-64	249	5	the	the	DET
bptjm-64	249	6	treatment	treatment	NOUN
bptjm-64	249	7	of	of	ADP
bptjm-64	249	8	cancer	cancer	NOUN
bptjm-64	249	9	:	:	PUNCT
bptjm-64	249	10	clinical	clinical	ADJ
bptjm-64	249	11	impact	impact	NOUN
bptjm-64	249	12	and	and	CCONJ
bptjm-64	249	13	mechanisms	mechanism	NOUN
bptjm-64	249	14	of	of	ADP
bptjm-64	249	15	response	response	NOUN
bptjm-64	249	16	and	and	CCONJ
bptjm-64	249	17	resistance	resistance	NOUN
bptjm-64	249	18	.	.	PUNCT
bptjm-64	250	1	annu	annu	PROPN
bptjm-64	250	2	rev	rev	PROPN
bptjm-64	250	3	pathol	pathol	NOUN
bptjm-64	250	4	.	.	PUNCT
bptjm-64	251	1	2021;16:223	2021;16:223	X
bptjm-64	251	2	-	-	SYM
bptjm-64	251	3	249	249	NUM
bptjm-64	251	4	.	.	PUNCT
bptjm-64	252	1	doi:10.1146	doi:10.1146	NOUN
bptjm-64	252	2	/	/	SYM
bptjm-64	252	3	annurev	annurev	NOUN
bptjm-64	252	4	-	-	PUNCT
bptjm-64	252	5	pathol-042020	pathol-042020	NOUN
bptjm-64	252	6	-	-	PUNCT
bptjm-64	252	7	042741	042741	NUM
bptjm-64	252	8	15	15	NUM
bptjm-64	252	9	.	.	PUNCT
bptjm-64	253	1	vesely	vesely	PROPN
bptjm-64	253	2	md	md	PROPN
bptjm-64	253	3	,	,	PUNCT
bptjm-64	253	4	zhang	zhang	PROPN
bptjm-64	253	5	t	t	PROPN
bptjm-64	253	6	,	,	PUNCT
bptjm-64	253	7	chen	chen	PROPN
bptjm-64	253	8	l.	l.	PROPN
bptjm-64	253	9	resistance	resistance	PROPN
bptjm-64	253	10	mechanisms	mechanism	NOUN
bptjm-64	253	11	to	to	ADP
bptjm-64	253	12	anti	anti	ADJ
bptjm-64	253	13	-	-	ADJ
bptjm-64	253	14	pd	pd	ADJ
bptjm-64	253	15	cancer	cancer	NOUN
bptjm-64	253	16	immunotherapy	immunotherapy	NOUN
bptjm-64	253	17	.	.	PUNCT
bptjm-64	254	1	annual	annual	ADJ
bptjm-64	254	2	review	review	NOUN
bptjm-64	254	3	of	of	ADP
bptjm-64	254	4	immunology	immunology	NOUN
bptjm-64	254	5	.	.	PUNCT
bptjm-64	255	1	2022;40(1):45	2022;40(1):45	X
bptjm-64	255	2	-	-	SYM
bptjm-64	255	3	74	74	NUM
bptjm-64	255	4	.	.	PUNCT
bptjm-64	256	1	doi:10.1146	doi:10.1146	NOUN
bptjm-64	256	2	/	/	SYM
bptjm-64	256	3	annurev	annurev	NOUN
bptjm-64	256	4	-	-	PUNCT
bptjm-64	256	5	immunol-070621	immunol-070621	NOUN
bptjm-64	256	6	-	-	PUNCT
bptjm-64	256	7	030155	030155	NUM
bptjm-64	256	8	16	16	NUM
bptjm-64	256	9	.	.	PUNCT
bptjm-64	257	1	feng	feng	PROPN
bptjm-64	257	2	y	y	PROPN
bptjm-64	257	3	,	,	PUNCT
bptjm-64	257	4	wu	wu	PROPN
bptjm-64	257	5	j	j	PROPN
bptjm-64	257	6	,	,	PUNCT
bptjm-64	257	7	chen	chen	PROPN
bptjm-64	257	8	j	j	PROPN
bptjm-64	257	9	,	,	PUNCT
bptjm-64	257	10	et	et	PROPN
bptjm-64	257	11	al	al	PROPN
bptjm-64	257	12	.	.	PUNCT
bptjm-64	257	13	targeting	target	VERB
bptjm-64	257	14	dual	dual	ADJ
bptjm-64	257	15	gene	gene	NOUN
bptjm-64	257	16	delivery	delivery	NOUN
bptjm-64	257	17	nanoparticles	nanoparticle	NOUN
bptjm-64	257	18	overcomes	overcome	VERB
bptjm-64	257	19	immune	immune	ADJ
bptjm-64	257	20	checkpoint	checkpoint	NOUN
bptjm-64	257	21	blockade	blockade	NOUN
bptjm-64	257	22	induced	induce	VERB
bptjm-64	257	23	adaptive	adaptive	ADJ
bptjm-64	257	24	resistance	resistance	NOUN
bptjm-64	257	25	and	and	CCONJ
bptjm-64	257	26	regulates	regulate	VERB
bptjm-64	257	27	tumor	tumor	NOUN
bptjm-64	257	28	microenvironment	microenvironment	NOUN
bptjm-64	257	29	for	for	ADP
bptjm-64	257	30	improved	improved	ADJ
bptjm-64	257	31	tumor	tumor	NOUN
bptjm-64	257	32	immunotherapy	immunotherapy	NOUN
bptjm-64	257	33	.	.	PUNCT
bptjm-64	258	1	nano	nano	NOUN
bptjm-64	258	2	today	today	NOUN
bptjm-64	258	3	.	.	PUNCT
bptjm-64	259	1	2021;38:101194	2021;38:101194	NUM
bptjm-64	259	2	.	.	PUNCT
bptjm-64	259	3	doi:10.1016	doi:10.1016	PROPN
bptjm-64	259	4	/	/	SYM
bptjm-64	259	5	j.nantod.2021.101194	j.nantod.2021.101194	PROPN
bptjm-64	259	6	17	17	NUM
bptjm-64	259	7	.	.	PUNCT
bptjm-64	260	1	qian	qian	PROPN
bptjm-64	260	2	j	j	PROPN
bptjm-64	260	3	,	,	PUNCT
bptjm-64	260	4	wang	wang	PROPN
bptjm-64	260	5	c	c	PROPN
bptjm-64	260	6	,	,	PUNCT
bptjm-64	260	7	wang	wang	PROPN
bptjm-64	260	8	b	b	PROPN
bptjm-64	260	9	,	,	PUNCT
bptjm-64	260	10	et	et	PROPN
bptjm-64	260	11	al	al	PROPN
bptjm-64	260	12	.	.	PUNCT
bptjm-64	261	1	the	the	DET
bptjm-64	261	2	ifn	ifn	PROPN
bptjm-64	261	3	-	-	PUNCT
bptjm-64	261	4	γ	γ	NOUN
bptjm-64	261	5	/	/	SYM
bptjm-64	261	6	pd	pd	PROPN
bptjm-64	261	7	-	-	PUNCT
bptjm-64	261	8	l1	l1	PROPN
bptjm-64	261	9	axis	axis	NOUN
bptjm-64	261	10	between	between	ADP
bptjm-64	261	11	t	t	NOUN
bptjm-64	261	12	cells	cell	NOUN
bptjm-64	261	13	and	and	CCONJ
bptjm-64	261	14	tumor	tumor	NOUN
bptjm-64	261	15	microenvironment	microenvironment	NOUN
bptjm-64	261	16	:	:	PUNCT
bptjm-64	261	17	hints	hint	VERB
bptjm-64	261	18	for	for	ADP
bptjm-64	261	19	glioma	glioma	ADJ
bptjm-64	261	20	anti	anti	ADJ
bptjm-64	261	21	-	-	ADJ
bptjm-64	261	22	pd-1	pd-1	ADJ
bptjm-64	261	23	/	/	SYM
bptjm-64	261	24	pd	pd	ADJ
bptjm-64	261	25	-	-	PROPN
bptjm-64	261	26	l1	l1	PROPN
bptjm-64	261	27	therapy	therapy	NOUN
bptjm-64	261	28	.	.	PUNCT
bptjm-64	262	1	j	j	PROPN
bptjm-64	262	2	neuroinflammation	neuroinflammation	NOUN
bptjm-64	262	3	.	.	PUNCT
bptjm-64	263	1	2018;15:290	2018;15:290	X
bptjm-64	263	2	.	.	PUNCT
bptjm-64	263	3	doi:10.1186	doi:10.1186	PROPN
bptjm-64	263	4	/	/	SYM
bptjm-64	263	5	s12974	s12974	PROPN
bptjm-64	263	6	-	-	PUNCT
bptjm-64	263	7	018	018	NUM
bptjm-64	263	8	-	-	PUNCT
bptjm-64	263	9	1330	1330	NUM
bptjm-64	263	10	-	-	SYM
bptjm-64	263	11	2	2	NUM
bptjm-64	263	12	18	18	NUM
bptjm-64	263	13	.	.	PUNCT
bptjm-64	264	1	coutzac	coutzac	PROPN
bptjm-64	264	2	c	c	PROPN
bptjm-64	264	3	,	,	PUNCT
bptjm-64	264	4	bibeau	bibeau	NOUN
bptjm-64	264	5	f	f	NOUN
bptjm-64	264	6	,	,	PUNCT
bptjm-64	264	7	ben	ben	PROPN
bptjm-64	264	8	abdelghani	abdelghani	PROPN
bptjm-64	264	9	m	m	PROPN
bptjm-64	264	10	,	,	PUNCT
bptjm-64	264	11	et	et	PROPN
bptjm-64	264	12	al	al	PROPN
bptjm-64	264	13	.	.	PUNCT
bptjm-64	264	14	immunotherapy	immunotherapy	PROPN
bptjm-64	264	15	in	in	ADP
bptjm-64	264	16	msi	msi	PROPN
bptjm-64	264	17	/	/	SYM
bptjm-64	265	1	dmmr	dmmr	PROPN
bptjm-64	265	2	tumors	tumor	NOUN
bptjm-64	265	3	in	in	ADP
bptjm-64	265	4	the	the	DET
bptjm-64	265	5	perioperative	perioperative	ADJ
bptjm-64	265	6	setting	setting	NOUN
bptjm-64	265	7	:	:	PUNCT
bptjm-64	265	8	the	the	DET
bptjm-64	265	9	imhotep	imhotep	NOUN
bptjm-64	265	10	trial	trial	NOUN
bptjm-64	265	11	.	.	PUNCT
bptjm-64	266	1	dig	dig	VERB
bptjm-64	266	2	liver	liver	NOUN
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bptjm-64	266	4	.	.	PUNCT
bptjm-64	267	1	2022;54(10):1335	2022;54(10):1335	X
bptjm-64	267	2	-	-	SYM
bptjm-64	267	3	1341	1341	NUM
bptjm-64	267	4	.	.	PUNCT
bptjm-64	268	1	doi:10.1016	doi:10.1016	PROPN
bptjm-64	268	2	/	/	SYM
bptjm-64	268	3	j.dld.2022.07.008	j.dld.2022.07.008	PROPN
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bptjm-64	268	5	.	.	PUNCT
bptjm-64	269	1	zhao	zhao	PROPN
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bptjm-64	269	3	,	,	PUNCT
bptjm-64	269	4	guo	guo	PROPN
bptjm-64	269	5	s	s	PROPN
bptjm-64	269	6	,	,	PUNCT
bptjm-64	269	7	deng	deng	PROPN
bptjm-64	269	8	j	j	PROPN
bptjm-64	269	9	,	,	PUNCT
bptjm-64	269	10	et	et	PROPN
bptjm-64	269	11	al	al	PROPN
bptjm-64	269	12	.	.	PROPN
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bptjm-64	269	14	/	/	PUNCT
bptjm-64	269	15	vegfr	vegfr	NOUN
bptjm-64	269	16	-	-	PUNCT
bptjm-64	269	17	targeted	target	VERB
bptjm-64	269	18	therapy	therapy	NOUN
bptjm-64	269	19	and	and	CCONJ
bptjm-64	269	20	immunotherapy	immunotherapy	NOUN
bptjm-64	269	21	in	in	ADP
bptjm-64	269	22	non	non	ADJ
bptjm-64	269	23	-	-	ADJ
bptjm-64	269	24	small	small	ADJ
bptjm-64	269	25	cell	cell	NOUN
bptjm-64	269	26	lung	lung	NOUN
bptjm-64	269	27	cancer	cancer	NOUN
bptjm-64	269	28	:	:	PUNCT
bptjm-64	269	29	targeting	target	VERB
bptjm-64	269	30	the	the	DET
bptjm-64	269	31	tumor	tumor	NOUN
bptjm-64	269	32	microenvironment	microenvironment	NOUN
bptjm-64	269	33	.	.	PUNCT
bptjm-64	270	1	international	international	ADJ
bptjm-64	270	2	journal	journal	PROPN
bptjm-64	270	3	of	of	ADP
bptjm-64	270	4	biological	biological	ADJ
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bptjm-64	270	6	.	.	PUNCT
bptjm-64	271	1	2022;18(9):3845	2022;18(9):3845	NUM
bptjm-64	271	2	-	-	SYM
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bptjm-64	272	5	.	.	PUNCT
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bptjm-64	273	23	(	(	PUNCT
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bptjm-64	273	25	)	)	PUNCT
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bptjm-64	273	28	-	-	ADJ
bptjm-64	273	29	leukemic	leukemic	ADJ
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bptjm-64	273	35	.	.	PUNCT
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bptjm-64	274	4	pmc	pmc	PROPN
bptjm-64	274	5	)	)	PUNCT
bptjm-64	274	6	.	.	PUNCT
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bptjm-64	275	2	/	/	SYM
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bptjm-64	275	5	.	.	PUNCT
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bptjm-64	276	3	,	,	PUNCT
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bptjm-64	276	6	,	,	PUNCT
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bptjm-64	276	12	.	.	PUNCT
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bptjm-64	276	16	/	/	SYM
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bptjm-64	276	19	reticulum	reticulum	NOUN
bptjm-64	276	20	stress	stress	NOUN
bptjm-64	276	21	response	response	NOUN
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bptjm-64	276	25	-	-	PUNCT
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bptjm-64	276	27	ovarian	ovarian	ADJ
bptjm-64	276	28	cancers	cancer	NOUN
bptjm-64	276	29	.	.	PUNCT
bptjm-64	277	1	pubmed	pubmed	PROPN
bptjm-64	277	2	central	central	PROPN
bptjm-64	277	3	(	(	PUNCT
bptjm-64	277	4	pmc	pmc	PROPN
bptjm-64	277	5	)	)	PUNCT
bptjm-64	277	6	.	.	PUNCT
bptjm-64	278	1	doi:10.1158/0008	doi:10.1158/0008	NOUN
bptjm-64	278	2	-	-	PUNCT
bptjm-64	278	3	5472.can-21	5472.can-21	NUM
bptjm-64	278	4	-	-	SYM
bptjm-64	278	5	1545	1545	NUM
bptjm-64	278	6	22	22	NUM
bptjm-64	278	7	.	.	PUNCT
bptjm-64	279	1	ma	ma	PROPN
bptjm-64	279	2	x	x	PROPN
bptjm-64	279	3	,	,	PUNCT
bptjm-64	279	4	bi	bi	PROPN
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bptjm-64	279	6	,	,	PUNCT
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bptjm-64	279	9	,	,	PUNCT
bptjm-64	279	10	et	et	PROPN
bptjm-64	279	11	al	al	PROPN
bptjm-64	279	12	.	.	PUNCT
bptjm-64	279	13	cholesterol	cholesterol	PROPN
bptjm-64	279	14	induces	induce	VERB
bptjm-64	279	15	cd8	cd8	PROPN
bptjm-64	279	16	+	+	PROPN
bptjm-64	279	17	t	t	NOUN
bptjm-64	279	18	cell	cell	NOUN
bptjm-64	279	19	exhaustion	exhaustion	NOUN
bptjm-64	279	20	in	in	ADP
bptjm-64	279	21	the	the	DET
bptjm-64	279	22	tumor	tumor	NOUN
bptjm-64	279	23	microenvironment	microenvironment	NOUN
bptjm-64	279	24	.	.	PUNCT
bptjm-64	280	1	cell	cell	NOUN
bptjm-64	280	2	metabolism	metabolism	NOUN
bptjm-64	280	3	.	.	PUNCT
bptjm-64	281	1	2019;30(1	2019;30(1	NUM
bptjm-64	281	2	)	)	PUNCT
bptjm-64	281	3	.	.	PUNCT
bptjm-64	282	1	doi:10.1016	doi:10.1016	PROPN
bptjm-64	282	2	/	/	SYM
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bptjm-64	282	5	.	.	PUNCT
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bptjm-64	283	6	,	,	PUNCT
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bptjm-64	283	12	.	.	PUNCT
bptjm-64	284	1	a	a	DET
bptjm-64	284	2	phase	phase	NOUN
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bptjm-64	284	6	vegf	vegf	PROPN
bptjm-64	284	7	-	-	PUNCT
bptjm-64	284	8	a	a	DET
bptjm-64	284	9	inhibition	inhibition	NOUN
bptjm-64	284	10	combined	combine	VERB
bptjm-64	284	11	with	with	ADP
bptjm-64	284	12	pd	pd	PROPN
bptjm-64	284	13	-	-	PUNCT
bptjm-64	284	14	l1	l1	PROPN
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bptjm-64	284	19	.	.	PUNCT
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bptjm-64	285	4	.	.	PUNCT
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bptjm-64	286	2	-	-	SYM
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bptjm-64	286	4	.	.	PUNCT
bptjm-64	287	1	published	publish	VERB
bptjm-64	287	2	2023	2023	NUM
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bptjm-64	287	4	25	25	NUM
bptjm-64	287	5	.	.	PUNCT
bptjm-64	288	1	doi:10.1158/2767	doi:10.1158/2767	PROPN
bptjm-64	288	2	-	-	PUNCT
bptjm-64	288	3	9764.crc-22	9764.crc-22	NUM
bptjm-64	288	4	-	-	PUNCT
bptjm-64	288	5	0420	0420	NUM
bptjm-64	288	6	24	24	NUM
bptjm-64	288	7	.	.	PUNCT
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bptjm-64	288	9	mf	mf	PROPN
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bptjm-64	288	15	ss	ss	PROPN
bptjm-64	288	16	,	,	PUNCT
bptjm-64	288	17	et	et	PROPN
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bptjm-64	288	19	.	.	PUNCT
bptjm-64	289	1	a	a	DET
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bptjm-64	289	3	-	-	PUNCT
bptjm-64	289	4	out	out	ADP
bptjm-64	289	5	cd8	cd8	PROPN
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bptjm-64	289	8	-	-	PUNCT
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bptjm-64	289	10	subset	subset	NOUN
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bptjm-64	289	13	the	the	DET
bptjm-64	289	14	tumor	tumor	NOUN
bptjm-64	289	15	microenvironment	microenvironment	NOUN
bptjm-64	289	16	and	and	CCONJ
bptjm-64	289	17	curbs	curb	NOUN
bptjm-64	289	18	cancer	cancer	NOUN
bptjm-64	289	19	immunotherapy	immunotherapy	NOUN
bptjm-64	289	20	.	.	PUNCT
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bptjm-64	290	3	.	.	PUNCT
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bptjm-64	291	2	-	-	SYM
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bptjm-64	291	4	.	.	PUNCT
bptjm-64	292	1	doi:10.1158/2159	doi:10.1158/2159	NOUN
bptjm-64	292	2	-	-	PUNCT
bptjm-64	292	3	8290.cd-20	8290.cd-20	NUM
bptjm-64	292	4	-	-	PUNCT
bptjm-64	292	5	0962	0962	NUM
bptjm-64	292	6	25	25	NUM
bptjm-64	292	7	.	.	PUNCT
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bptjm-64	293	20	.	.	PUNCT
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bptjm-64	294	5	.	.	PUNCT
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bptjm-64	295	2	.	.	PUNCT
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bptjm-64	295	7	.	.	PUNCT
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bptjm-64	301	2	/	/	SYM
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bptjm-64	301	5	.	.	PUNCT
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bptjm-64	304	7	|	|	ADV
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bptjm-64	305	5	.	.	PUNCT
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bptjm-64	308	2	-	-	SYM
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bptjm-64	308	4	.	.	PUNCT
bptjm-64	309	1	doi:10.1007	doi:10.1007	PROPN
bptjm-64	309	2	/	/	SYM
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bptjm-64	309	4	-	-	PUNCT
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bptjm-64	309	8	-	-	SYM
bptjm-64	309	9	1	1	NUM
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bptjm-64	310	9	,	,	PUNCT
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bptjm-64	310	45	,	,	PUNCT
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bptjm-64	311	8	-	-	PUNCT
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bptjm-64	312	4	-	-	PUNCT
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bptjm-64	312	8	.	.	PUNCT
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bptjm-64	313	2	.	.	X
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bptjm-64	313	10	.	.	PUNCT
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bptjm-64	315	5	,	,	PUNCT
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bptjm-64	315	7	-	-	SYM
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bptjm-64	315	9	.	.	PUNCT
bptjm-64	316	1	doi:10.1007/978	doi:10.1007/978	PROPN
bptjm-64	316	2	-	-	PUNCT
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bptjm-64	316	4	-	-	PUNCT
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bptjm-64	316	6	-	-	PUNCT
bptjm-64	316	7	43093	43093	NUM
bptjm-64	316	8	-	-	SYM
bptjm-64	316	9	1_3	1_3	NUM
bptjm-64	316	10	31	31	NUM
bptjm-64	316	11	.	.	PUNCT
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bptjm-64	317	9	,	,	PUNCT
bptjm-64	317	10	soria	soria	PROPN
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bptjm-64	317	12	,	,	PUNCT
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bptjm-64	317	14	g	g	PROPN
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bptjm-64	317	21	microenvironment	microenvironment	NOUN
bptjm-64	317	22	:	:	PUNCT
bptjm-64	317	23	removing	remove	VERB
bptjm-64	317	24	obstruction	obstruction	NOUN
bptjm-64	317	25	to	to	PART
bptjm-64	317	26	anticancer	anticancer	VERB
bptjm-64	317	27	immune	immune	ADJ
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bptjm-64	317	29	and	and	CCONJ
bptjm-64	317	30	immunotherapy	immunotherapy	NOUN
bptjm-64	317	31	.	.	PUNCT
bptjm-64	318	1	ann	ann	PROPN
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bptjm-64	319	2	-	-	SYM
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bptjm-64	319	4	.	.	PUNCT
bptjm-64	320	1	doi:10.1093	doi:10.1093	NOUN
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bptjm-64	320	5	mdw168	mdw168	PROPN
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bptjm-64	320	7	.	.	PUNCT
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bptjm-64	321	8	h	h	PROPN
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bptjm-64	321	12	,	,	PUNCT
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bptjm-64	322	3	(	(	PUNCT
bptjm-64	322	4	pmc	pmc	PROPN
bptjm-64	322	5	)	)	PUNCT
bptjm-64	322	6	.	.	PUNCT
bptjm-64	323	1	doi:10.1200	doi:10.1200	PROPN
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bptjm-64	323	5	.	.	PUNCT
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bptjm-64	324	9	.	.	PUNCT
bptjm-64	325	1	the	the	DET
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bptjm-64	326	1	pubmed	pubmed	PROPN
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bptjm-64	326	3	(	(	PUNCT
bptjm-64	326	4	pmc	pmc	PROPN
bptjm-64	326	5	)	)	PUNCT
bptjm-64	326	6	.	.	PUNCT
bptjm-64	327	1	doi:10.1016	doi:10.1016	PROPN
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bptjm-64	327	5	.	.	PUNCT
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bptjm-64	328	6	,	,	PUNCT
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bptjm-64	328	30	-	-	PUNCT
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bptjm-64	328	38	-	-	PUNCT
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bptjm-64	329	1	[	[	X
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bptjm-64	331	4	.	.	PUNCT
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bptjm-64	332	2	-	-	SYM
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bptjm-64	332	4	.	.	PUNCT
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bptjm-64	333	5	.	.	PUNCT
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bptjm-64	334	39	.	.	PUNCT
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bptjm-64	336	5	005320	005320	NUM
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bptjm-64	336	7	.	.	PUNCT
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bptjm-64	338	6	.	.	PUNCT
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bptjm-64	343	1	doi:10.1016	doi:10.1016	PROPN
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bptjm-64	344	2	.	.	PUNCT
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bptjm-64	345	38	.	.	PUNCT
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bptjm-64	347	4	-	-	PUNCT
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bptjm-64	347	6	-	-	PUNCT
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bptjm-64	347	8	-	-	SYM
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bptjm-64	347	11	.	.	PUNCT
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bptjm-64	348	11	,	,	PUNCT
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bptjm-64	348	13	al	al	PROPN
bptjm-64	348	14	.	.	PROPN
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bptjm-64	348	19	adjuvant	adjuvant	ADJ
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bptjm-64	348	24	-	-	PUNCT
bptjm-64	348	25	in	in	ADP
bptjm-64	348	26	�	�	NOUN
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bptjm-64	348	29	in	in	ADP
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bptjm-64	348	32	cervical	cervical	ADJ
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bptjm-64	348	34	.	.	PUNCT
bptjm-64	349	1	pubmed	pubmed	PROPN
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bptjm-64	349	3	(	(	PUNCT
bptjm-64	349	4	pmc	pmc	PROPN
bptjm-64	349	5	)	)	PUNCT
bptjm-64	349	6	.	.	PUNCT
bptjm-64	350	1	berkeley	berkeley	PROPN
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bptjm-64	350	7	|	|	ADV
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bptjm-64	350	10	/	/	SYM
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bptjm-64	350	13	.	.	PUNCT
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bptjm-64	351	3	,	,	PUNCT
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bptjm-64	351	9	,	,	PUNCT
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bptjm-64	351	12	.	.	PUNCT
bptjm-64	352	1	the	the	DET
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bptjm-64	352	4	of	of	ADP
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bptjm-64	352	10	microenvironment	microenvironment	NOUN
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bptjm-64	352	13	chemoradiotherapy	chemoradiotherapy	NOUN
bptjm-64	352	14	of	of	ADP
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bptjm-64	352	16	cancer	cancer	NOUN
bptjm-64	352	17	:	:	PUNCT
bptjm-64	352	18	a	a	DET
bptjm-64	352	19	prospective	prospective	ADJ
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bptjm-64	352	21	trial	trial	NOUN
bptjm-64	352	22	.	.	PUNCT
bptjm-64	353	1	int	int	NOUN
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bptjm-64	353	7	.	.	PUNCT
bptjm-64	354	1	2021;110(5):1432	2021;110(5):1432	NUM
bptjm-64	354	2	-	-	SYM
bptjm-64	354	3	1441	1441	NUM
bptjm-64	354	4	.	.	PUNCT
bptjm-64	355	1	doi:10.1016	doi:10.1016	PROPN
bptjm-64	355	2	/	/	SYM
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bptjm-64	355	5	.	.	PUNCT
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bptjm-64	356	3	,	,	PUNCT
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bptjm-64	356	6	,	,	PUNCT
bptjm-64	356	7	li	li	PROPN
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bptjm-64	356	9	,	,	PUNCT
bptjm-64	356	10	et	et	PROPN
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bptjm-64	356	12	.	.	PUNCT
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bptjm-64	357	5	e	e	NOUN
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bptjm-64	357	7	cacy	cacy	NOUN
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bptjm-64	357	10	-	-	PUNCT
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bptjm-64	357	15	.	.	PUNCT
bptjm-64	358	1	pubmed	pubmed	PROPN
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bptjm-64	358	3	(	(	PUNCT
bptjm-64	358	4	pmc	pmc	PROPN
bptjm-64	358	5	)	)	PUNCT
bptjm-64	358	6	.	.	PUNCT
bptjm-64	359	1	doi:10.1038	doi:10.1038	NOUN
bptjm-64	359	2	/	/	SYM
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bptjm-64	359	4	-	-	PUNCT
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bptjm-64	359	6	-	-	PUNCT
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bptjm-64	359	8	-	-	PUNCT
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bptjm-64	359	11	.	.	PUNCT
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bptjm-64	361	11	.	.	PUNCT
bptjm-64	362	1	pubmed	pubmed	PROPN
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bptjm-64	362	3	(	(	PUNCT
bptjm-64	362	4	pmc	pmc	PROPN
bptjm-64	362	5	)	)	PUNCT
bptjm-64	362	6	.	.	PUNCT
bptjm-64	363	1	doi:10.1016	doi:10.1016	PROPN
bptjm-64	363	2	/	/	SYM
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bptjm-64	363	5	.	.	PUNCT
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bptjm-64	364	3	,	,	PUNCT
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bptjm-64	364	6	,	,	PUNCT
bptjm-64	364	7	y.	y.	PROPN
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bptjm-64	364	10	,	,	PUNCT
bptjm-64	364	11	et	et	PROPN
bptjm-64	364	12	al	al	PROPN
bptjm-64	364	13	.	.	PROPN
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bptjm-64	364	15	targeting	targeting	NOUN
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bptjm-64	364	20	(	(	PUNCT
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bptjm-64	364	28	and	and	CCONJ
bptjm-64	364	29	reinvigorates	reinvigorate	VERB
bptjm-64	364	30	dysfunctional	dysfunctional	ADJ
bptjm-64	364	31	cd8	cd8	PROPN
bptjm-64	364	32	+	+	PROPN
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bptjm-64	364	34	cells	cell	NOUN
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bptjm-64	364	37	-	-	PUNCT
bptjm-64	364	38	resistant	resistant	ADJ
bptjm-64	364	39	and	and	CCONJ
bptjm-64	364	40	metastatic	metastatic	ADJ
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bptjm-64	364	42	.	.	PUNCT
bptjm-64	365	1	pubmed	pubmed	PROPN
bptjm-64	365	2	central	central	PROPN
bptjm-64	365	3	(	(	PUNCT
bptjm-64	365	4	pmc	pmc	PROPN
bptjm-64	365	5	)	)	PUNCT
bptjm-64	365	6	.	.	PUNCT
bptjm-64	366	1	doi:10.3390	doi:10.3390	NOUN
bptjm-64	366	2	/	/	SYM
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bptjm-64	366	5	.	.	PUNCT
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bptjm-64	367	3	,	,	PUNCT
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bptjm-64	367	9	.	.	PUNCT
bptjm-64	368	1	pubmed	pubmed	PROPN
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bptjm-64	368	3	(	(	PUNCT
bptjm-64	368	4	pmc	pmc	PROPN
bptjm-64	368	5	)	)	PUNCT
bptjm-64	368	6	.	.	PUNCT
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bptjm-64	369	2	/	/	SYM
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bptjm-64	369	6	.	.	PUNCT
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bptjm-64	371	1	pubmed	pubmed	PROPN
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bptjm-64	371	3	(	(	PUNCT
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bptjm-64	371	5	)	)	PUNCT
bptjm-64	371	6	.	.	PUNCT
bptjm-64	372	1	doi:10.1007	doi:10.1007	VERB
bptjm-64	372	2	/	/	SYM
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bptjm-64	372	4	-	-	PUNCT
bptjm-64	372	5	011	011	NUM
bptjm-64	372	6	-	-	PUNCT
bptjm-64	372	7	0066	0066	NUM
bptjm-64	372	8	-	-	SYM
bptjm-64	372	9	7	7	NUM
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bptjm-64	372	11	.	.	PUNCT
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bptjm-64	373	3	,	,	PUNCT
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bptjm-64	373	7	of	of	ADP
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bptjm-64	373	10	-	-	PUNCT
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bptjm-64	373	12	”	"	PUNCT
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bptjm-64	373	14	lymphocytic	lymphocytic	ADJ
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bptjm-64	373	16	in	in	ADP
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bptjm-64	373	18	times	time	NOUN
bptjm-64	373	19	of	of	ADP
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bptjm-64	373	21	.	.	PUNCT
bptjm-64	374	1	pubmed	pubmed	PROPN
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bptjm-64	374	3	(	(	PUNCT
bptjm-64	374	4	pmc	pmc	PROPN
bptjm-64	374	5	)	)	PUNCT
bptjm-64	374	6	.	.	PUNCT
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bptjm-64	375	2	/	/	SYM
bptjm-64	375	3	haematol.2020.246504	haematol.2020.246504	PROPN
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bptjm-64	375	5	.	.	PUNCT
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bptjm-64	376	9	.	.	PUNCT
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bptjm-64	377	4	t	t	NOUN
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bptjm-64	377	8	-	-	PUNCT
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bptjm-64	377	12	.	.	PUNCT
bptjm-64	378	1	cancer	cancer	NOUN
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bptjm-64	379	2	-	-	SYM
bptjm-64	379	3	488	488	NUM
bptjm-64	379	4	.	.	PUNCT
bptjm-64	380	1	doi:10.1016	doi:10.1016	PROPN
bptjm-64	380	2	/	/	SYM
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bptjm-64	380	5	.	.	PUNCT
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bptjm-64	381	9	,	,	PUNCT
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bptjm-64	381	12	.	.	PROPN
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bptjm-64	389	4	.	.	PUNCT
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bptjm-64	389	10	-	-	PUNCT
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bptjm-64	390	9	.	.	PUNCT
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bptjm-64	390	26	-	-	ADJ
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bptjm-64	390	31	)	)	PUNCT
bptjm-64	390	32	.	.	PUNCT
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bptjm-64	391	2	identi	identi	X
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bptjm-64	391	7	.	.	PUNCT
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bptjm-64	392	5	,	,	PUNCT
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bptjm-64	392	7	.	.	PUNCT
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bptjm-64	395	14	in	in	ADP
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bptjm-64	395	17	chemotherapy	chemotherapy	NOUN
bptjm-64	395	18	in	in	ADP
bptjm-64	395	19	patients	patient	NOUN
bptjm-64	395	20	with	with	ADP
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bptjm-64	395	22	.	.	PUNCT
bptjm-64	396	1	clinicaltrials.gov	clinicaltrials.gov	X
bptjm-64	396	2	identi	identi	X
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bptjm-64	396	7	.	.	PUNCT
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bptjm-64	397	5	,	,	PUNCT
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bptjm-64	397	7	.	.	PUNCT
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bptjm-64	398	6	.	.	PUNCT
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bptjm-64	400	8	.	.	PUNCT
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