id	sid	tid	token	lemma	pos
bptjm-67	1	1	chang	chang	PROPN
bptjm-67	1	2	references	reference	VERB
bptjm-67	1	3	berkeley	berkeley	PROPN
bptjm-67	1	4	pharma	pharma	PROPN
bptjm-67	1	5	tech	tech	NOUN
bptjm-67	1	6	journal	journal	NOUN
bptjm-67	1	7	of	of	ADP
bptjm-67	1	8	medicine	medicine	NOUN
bptjm-67	1	9	correspondence	correspondence	NOUN
bptjm-67	1	10	:	:	PUNCT
bptjm-67	1	11	yoeu@ucsd.edu	yoeu@ucsd.edu	PROPN
bptjm-67	1	12	keywords	keyword	NOUN
bptjm-67	1	13	:	:	PUNCT
bptjm-67	1	14	neurovascular	neurovascular	ADJ
bptjm-67	1	15	coupling	coupling	NOUN
bptjm-67	1	16	dementia	dementia	NOUN
bptjm-67	1	17	alzheimer	alzheimer	PROPN
bptjm-67	1	18	's	's	PART
bptjm-67	1	19	disease	disease	NOUN
bptjm-67	1	20	parkinson	parkinson	NOUN
bptjm-67	1	21	's	's	PART
bptjm-67	1	22	disease	disease	NOUN
bptjm-67	1	23	vascular	vascular	ADJ
bptjm-67	1	24	dysfunction	dysfunction	NOUN
bptjm-67	1	25	published	publish	VERB
bptjm-67	1	26	july	july	PROPN
bptjm-67	1	27	31	31	NUM
bptjm-67	1	28	,	,	PUNCT
bptjm-67	1	29	2025	2025	NUM
bptjm-67	1	30	full	full	ADJ
bptjm-67	1	31	open	open	ADJ
bptjm-67	1	32	access	access	NOUN
bptjm-67	1	33	creative	creative	ADJ
bptjm-67	1	34	commons	common	NOUN
bptjm-67	1	35	attribution	attribution	NOUN
bptjm-67	1	36	license	license	VERB
bptjm-67	1	37	4.0	4.0	NUM
bptjm-67	1	38	abstract	abstract	ADJ
bptjm-67	1	39	cognitive	cognitive	ADJ
bptjm-67	1	40	decline	decline	NOUN
bptjm-67	1	41	—	—	PUNCT
bptjm-67	1	42	including	include	VERB
bptjm-67	1	43	dementia	dementia	PROPN
bptjm-67	1	44	,	,	PUNCT
bptjm-67	1	45	alzheimer	alzheimer	PROPN
bptjm-67	1	46	’s	’s	PART
bptjm-67	1	47	disease	disease	NOUN
bptjm-67	1	48	,	,	PUNCT
bptjm-67	1	49	and	and	CCONJ
bptjm-67	1	50	parkinson	parkinson	NOUN
bptjm-67	1	51	’s	’s	PART
bptjm-67	1	52	disease	disease	NOUN
bptjm-67	1	53	—	—	PUNCT
bptjm-67	1	54	is	be	AUX
bptjm-67	1	55	a	a	DET
bptjm-67	1	56	growing	grow	VERB
bptjm-67	1	57	global	global	ADJ
bptjm-67	1	58	health	health	NOUN
bptjm-67	1	59	concern	concern	NOUN
bptjm-67	1	60	.	.	PUNCT
bptjm-67	2	1	these	these	DET
bptjm-67	2	2	neurodegenerative	neurodegenerative	ADJ
bptjm-67	2	3	disorders	disorder	NOUN
bptjm-67	2	4	affect	affect	VERB
bptjm-67	2	5	approximately	approximately	ADV
bptjm-67	2	6	50	50	NUM
bptjm-67	2	7	million	million	NUM
bptjm-67	2	8	people	people	NOUN
bptjm-67	2	9	worldwide	worldwide	ADV
bptjm-67	2	10	.	.	PUNCT
bptjm-67	3	1	in	in	ADP
bptjm-67	3	2	the	the	DET
bptjm-67	3	3	united	united	PROPN
bptjm-67	3	4	states	states	PROPN
bptjm-67	3	5	,	,	PUNCT
bptjm-67	3	6	nearly	nearly	ADV
bptjm-67	3	7	two	two	NUM
bptjm-67	3	8	out	out	ADP
bptjm-67	3	9	of	of	ADP
bptjm-67	3	10	three	three	NUM
bptjm-67	3	11	seniors	senior	NOUN
bptjm-67	3	12	experience	experience	VERB
bptjm-67	3	13	some	some	DET
bptjm-67	3	14	form	form	NOUN
bptjm-67	3	15	of	of	ADP
bptjm-67	3	16	cognitive	cognitive	ADJ
bptjm-67	3	17	impairment	impairment	NOUN
bptjm-67	3	18	.	.	PUNCT
bptjm-67	4	1	since	since	SCONJ
bptjm-67	4	2	the	the	DET
bptjm-67	4	3	1990s	1990	NOUN
bptjm-67	4	4	,	,	PUNCT
bptjm-67	4	5	the	the	DET
bptjm-67	4	6	prevalence	prevalence	NOUN
bptjm-67	4	7	of	of	ADP
bptjm-67	4	8	mild	mild	ADJ
bptjm-67	4	9	cognitive	cognitive	ADJ
bptjm-67	4	10	impairment	impairment	NOUN
bptjm-67	4	11	has	have	AUX
bptjm-67	4	12	been	be	AUX
bptjm-67	4	13	rising	rise	VERB
bptjm-67	4	14	in	in	ADP
bptjm-67	4	15	the	the	DET
bptjm-67	4	16	u.s	u.s	PROPN
bptjm-67	4	17	.	.	PROPN
bptjm-67	4	18	and	and	CCONJ
bptjm-67	4	19	is	be	AUX
bptjm-67	4	20	projected	project	VERB
bptjm-67	4	21	to	to	PART
bptjm-67	4	22	continue	continue	VERB
bptjm-67	4	23	increasing	increase	VERB
bptjm-67	4	24	for	for	ADP
bptjm-67	4	25	future	future	ADJ
bptjm-67	4	26	decades	decade	NOUN
bptjm-67	4	27	.	.	PUNCT
bptjm-67	5	1	these	these	DET
bptjm-67	5	2	alarming	alarming	ADJ
bptjm-67	5	3	trends	trend	NOUN
bptjm-67	5	4	underscore	underscore	VERB
bptjm-67	5	5	the	the	DET
bptjm-67	5	6	urgent	urgent	ADJ
bptjm-67	5	7	need	need	NOUN
bptjm-67	5	8	for	for	ADP
bptjm-67	5	9	more	more	ADV
bptjm-67	5	10	effective	effective	ADJ
bptjm-67	5	11	methods	method	NOUN
bptjm-67	5	12	of	of	ADP
bptjm-67	5	13	early	early	ADJ
bptjm-67	5	14	detection	detection	NOUN
bptjm-67	5	15	and	and	CCONJ
bptjm-67	5	16	treatment	treatment	NOUN
bptjm-67	5	17	that	that	PRON
bptjm-67	5	18	address	address	VERB
bptjm-67	5	19	the	the	DET
bptjm-67	5	20	physical	physical	ADJ
bptjm-67	5	21	,	,	PUNCT
bptjm-67	5	22	emotional	emotional	ADJ
bptjm-67	5	23	,	,	PUNCT
bptjm-67	5	24	and	and	CCONJ
bptjm-67	5	25	cognitive	cognitive	ADJ
bptjm-67	5	26	needs	need	NOUN
bptjm-67	5	27	of	of	ADP
bptjm-67	5	28	affected	affected	ADJ
bptjm-67	5	29	individuals	individual	NOUN
bptjm-67	5	30	.	.	PUNCT
bptjm-67	6	1	emerging	emerge	VERB
bptjm-67	6	2	evidence	evidence	NOUN
bptjm-67	6	3	suggests	suggest	VERB
bptjm-67	6	4	that	that	SCONJ
bptjm-67	6	5	neurovascular	neurovascular	ADJ
bptjm-67	6	6	coupling	coupling	NOUN
bptjm-67	6	7	(	(	PUNCT
bptjm-67	6	8	nvc	nvc	NOUN
bptjm-67	6	9	)	)	PUNCT
bptjm-67	6	10	—	—	PUNCT
bptjm-67	6	11	the	the	DET
bptjm-67	6	12	critical	critical	ADJ
bptjm-67	6	13	process	process	NOUN
bptjm-67	6	14	linking	link	VERB
bptjm-67	6	15	brain	brain	NOUN
bptjm-67	6	16	activity	activity	NOUN
bptjm-67	6	17	to	to	ADP
bptjm-67	6	18	dynamic	dynamic	ADJ
bptjm-67	6	19	blood	blood	NOUN
bptjm-67	6	20	flow	flow	NOUN
bptjm-67	6	21	—	—	PUNCT
bptjm-67	6	22	plays	play	VERB
bptjm-67	6	23	an	an	DET
bptjm-67	6	24	essential	essential	ADJ
bptjm-67	6	25	role	role	NOUN
bptjm-67	6	26	in	in	ADP
bptjm-67	6	27	regulating	regulate	VERB
bptjm-67	6	28	brain	brain	NOUN
bptjm-67	6	29	energetics	energetic	NOUN
bptjm-67	6	30	and	and	CCONJ
bptjm-67	6	31	function	function	NOUN
bptjm-67	6	32	,	,	PUNCT
bptjm-67	6	33	and	and	CCONJ
bptjm-67	6	34	may	may	AUX
bptjm-67	6	35	contribute	contribute	VERB
bptjm-67	6	36	to	to	ADP
bptjm-67	6	37	cognitive	cognitive	ADJ
bptjm-67	6	38	dysfunction	dysfunction	NOUN
bptjm-67	6	39	when	when	SCONJ
bptjm-67	6	40	impaired	impaired	ADJ
bptjm-67	6	41	.	.	PUNCT
bptjm-67	7	1	this	this	DET
bptjm-67	7	2	review	review	NOUN
bptjm-67	7	3	delves	delve	VERB
bptjm-67	7	4	into	into	ADP
bptjm-67	7	5	the	the	DET
bptjm-67	7	6	characteristics	characteristic	NOUN
bptjm-67	7	7	of	of	ADP
bptjm-67	7	8	nvc	nvc	NOUN
bptjm-67	7	9	and	and	CCONJ
bptjm-67	7	10	the	the	DET
bptjm-67	7	11	neurovascular	neurovascular	ADJ
bptjm-67	7	12	unit	unit	NOUN
bptjm-67	7	13	(	(	PUNCT
bptjm-67	7	14	nvu	nvu	NOUN
bptjm-67	7	15	)	)	PUNCT
bptjm-67	7	16	,	,	PUNCT
bptjm-67	7	17	examines	examine	VERB
bptjm-67	7	18	early	early	ADJ
bptjm-67	7	19	detection	detection	NOUN
bptjm-67	7	20	strategies	strategy	NOUN
bptjm-67	7	21	targeting	target	VERB
bptjm-67	7	22	nvc	nvc	NOUN
bptjm-67	7	23	-	-	PUNCT
bptjm-67	7	24	related	relate	VERB
bptjm-67	7	25	biomarkers	biomarker	NOUN
bptjm-67	7	26	,	,	PUNCT
bptjm-67	7	27	and	and	CCONJ
bptjm-67	7	28	discusses	discuss	VERB
bptjm-67	7	29	current	current	ADJ
bptjm-67	7	30	and	and	CCONJ
bptjm-67	7	31	investigational	investigational	ADJ
bptjm-67	7	32	treatments	treatment	NOUN
bptjm-67	7	33	for	for	ADP
bptjm-67	7	34	nvc	nvc	NOUN
bptjm-67	7	35	-	-	PUNCT
bptjm-67	7	36	associated	associate	VERB
bptjm-67	7	37	cognitive	cognitive	ADJ
bptjm-67	7	38	disorders	disorder	NOUN
bptjm-67	7	39	.	.	PUNCT
bptjm-67	8	1	the	the	DET
bptjm-67	8	2	pulse	pulse	NOUN
bptjm-67	8	3	of	of	ADP
bptjm-67	8	4	cognition	cognition	NOUN
bptjm-67	8	5	:	:	PUNCT
bptjm-67	8	6	investigating	investigate	VERB
bptjm-67	8	7	neurovascular	neurovascular	ADJ
bptjm-67	8	8	coupling	coupling	NOUN
bptjm-67	8	9	's	's	PART
bptjm-67	8	10	role	role	NOUN
bptjm-67	8	11	in	in	ADP
bptjm-67	8	12	cognition	cognition	NOUN
bptjm-67	8	13	and	and	CCONJ
bptjm-67	8	14	therapeutic	therapeutic	ADJ
bptjm-67	8	15	promise	promise	NOUN
bptjm-67	8	16	for	for	ADP
bptjm-67	8	17	alzheimer	alzheimer	PROPN
bptjm-67	8	18	’s	’s	PART
bptjm-67	8	19	,	,	PUNCT
bptjm-67	8	20	parkinson	parkinson	NOUN
bptjm-67	8	21	’s	’s	PART
bptjm-67	8	22	,	,	PUNCT
bptjm-67	8	23	and	and	CCONJ
bptjm-67	8	24	dementia	dementia	NOUN
bptjm-67	8	25	by	by	ADP
bptjm-67	8	26	:	:	PUNCT
bptjm-67	8	27	irene	irene	PROPN
bptjm-67	8	28	eu	eu	PROPN
bptjm-67	8	29	,	,	PUNCT
bptjm-67	8	30	cindy	cindy	PROPN
bptjm-67	8	31	lu	lu	PROPN
bptjm-67	8	32	,	,	PUNCT
bptjm-67	8	33	kalp	kalp	PROPN
bptjm-67	8	34	soni	soni	PROPN
bptjm-67	8	35	and	and	CCONJ
bptjm-67	8	36	evan	evan	PROPN
bptjm-67	8	37	lee	lee	PROPN
bptjm-67	8	38	1	1	X
bptjm-67	8	39	.	.	PUNCT
bptjm-67	8	40	introduction	introduction	NOUN
bptjm-67	8	41	1.1	1.1	NUM
bptjm-67	8	42	cognitive	cognitive	ADJ
bptjm-67	8	43	decline	decline	NOUN
bptjm-67	8	44	cognitive	cognitive	ADJ
bptjm-67	8	45	decline	decline	NOUN
bptjm-67	8	46	is	be	AUX
bptjm-67	8	47	an	an	DET
bptjm-67	8	48	escalating	escalate	VERB
bptjm-67	8	49	public	public	ADJ
bptjm-67	8	50	health	health	NOUN
bptjm-67	8	51	concern	concern	NOUN
bptjm-67	8	52	,	,	PUNCT
bptjm-67	8	53	driven	drive	VERB
bptjm-67	8	54	in	in	ADP
bptjm-67	8	55	part	part	NOUN
bptjm-67	8	56	by	by	ADP
bptjm-67	8	57	the	the	DET
bptjm-67	8	58	aging	age	VERB
bptjm-67	8	59	global	global	ADJ
bptjm-67	8	60	population	population	NOUN
bptjm-67	8	61	.	.	PUNCT
bptjm-67	9	1	data	datum	NOUN
bptjm-67	9	2	show	show	VERB
bptjm-67	9	3	that	that	SCONJ
bptjm-67	9	4	nearly	nearly	ADV
bptjm-67	9	5	20	20	NUM
bptjm-67	9	6	%	%	NOUN
bptjm-67	9	7	of	of	ADP
bptjm-67	9	8	adults	adult	NOUN
bptjm-67	9	9	aged	age	VERB
bptjm-67	9	10	50	50	NUM
bptjm-67	9	11	and	and	CCONJ
bptjm-67	9	12	older	old	ADJ
bptjm-67	9	13	worldwide	worldwide	ADJ
bptjm-67	9	14	experience	experience	NOUN
bptjm-67	9	15	some	some	DET
bptjm-67	9	16	degree	degree	NOUN
bptjm-67	9	17	of	of	ADP
bptjm-67	9	18	cognitive	cognitive	ADJ
bptjm-67	9	19	decline.¹	decline.¹	NOUN
bptjm-67	9	20	in	in	ADP
bptjm-67	9	21	the	the	DET
bptjm-67	9	22	united	united	PROPN
bptjm-67	9	23	states	states	PROPN
bptjm-67	9	24	,	,	PUNCT
bptjm-67	9	25	approximately	approximately	ADV
bptjm-67	9	26	two	two	NUM
bptjm-67	9	27	out	out	ADP
bptjm-67	9	28	of	of	ADP
bptjm-67	9	29	three	three	NUM
bptjm-67	9	30	adults	adult	NOUN
bptjm-67	9	31	aged	age	VERB
bptjm-67	9	32	70	70	NUM
bptjm-67	9	33	or	or	CCONJ
bptjm-67	9	34	older	old	ADJ
bptjm-67	9	35	have	have	VERB
bptjm-67	9	36	some	some	DET
bptjm-67	9	37	form	form	NOUN
bptjm-67	9	38	of	of	ADP
bptjm-67	9	39	cognitive	cognitive	ADJ
bptjm-67	9	40	impairment	impairment	NOUN
bptjm-67	9	41	,	,	PUNCT
bptjm-67	9	42	while	while	SCONJ
bptjm-67	9	43	one	one	NUM
bptjm-67	9	44	in	in	ADP
bptjm-67	9	45	three	three	NUM
bptjm-67	9	46	individuals	individual	NOUN
bptjm-67	9	47	aged	age	VERB
bptjm-67	9	48	85	85	NUM
bptjm-67	9	49	or	or	CCONJ
bptjm-67	9	50	older	old	ADJ
bptjm-67	9	51	suffers	suffer	NOUN
bptjm-67	9	52	from	from	ADP
bptjm-67	9	53	more	more	ADV
bptjm-67	9	54	severe	severe	ADJ
bptjm-67	9	55	conditions	condition	NOUN
bptjm-67	9	56	such	such	ADJ
bptjm-67	9	57	as	as	ADP
bptjm-67	9	58	alzheimer	alzheimer	PROPN
bptjm-67	9	59	’s	’s	PART
bptjm-67	9	60	disease.2,3	disease.2,3	ADV
bptjm-67	9	61	these	these	DET
bptjm-67	9	62	statistics	statistic	NOUN
bptjm-67	9	63	highlight	highlight	VERB
bptjm-67	9	64	the	the	DET
bptjm-67	9	65	urgent	urgent	ADJ
bptjm-67	9	66	need	need	NOUN
bptjm-67	9	67	for	for	ADP
bptjm-67	9	68	comprehensive	comprehensive	ADJ
bptjm-67	9	69	interventions	intervention	NOUN
bptjm-67	9	70	.	.	PUNCT
bptjm-67	10	1	effective	effective	ADJ
bptjm-67	10	2	strategies	strategy	NOUN
bptjm-67	10	3	include	include	VERB
bptjm-67	10	4	pharmacological	pharmacological	ADJ
bptjm-67	10	5	treatments	treatment	NOUN
bptjm-67	10	6	,	,	PUNCT
bptjm-67	10	7	nutraceutical	nutraceutical	ADJ
bptjm-67	10	8	approaches	approach	NOUN
bptjm-67	10	9	,	,	PUNCT
bptjm-67	10	10	and	and	CCONJ
bptjm-67	10	11	vascular	vascular	ADJ
bptjm-67	10	12	-	-	PUNCT
bptjm-67	10	13	targeted	target	VERB
bptjm-67	10	14	therapies	therapy	NOUN
bptjm-67	10	15	aimed	aim	VERB
bptjm-67	10	16	at	at	ADP
bptjm-67	10	17	addressing	address	VERB
bptjm-67	10	18	both	both	CCONJ
bptjm-67	10	19	the	the	DET
bptjm-67	10	20	underlying	underlie	VERB
bptjm-67	10	21	causes	cause	NOUN
bptjm-67	10	22	and	and	CCONJ
bptjm-67	10	23	the	the	DET
bptjm-67	10	24	consequences	consequence	NOUN
bptjm-67	10	25	of	of	ADP
bptjm-67	10	26	cognitive	cognitive	ADJ
bptjm-67	10	27	decline	decline	NOUN
bptjm-67	10	28	.	.	PUNCT
bptjm-67	11	1	figure	figure	NOUN
bptjm-67	11	2	1	1	NUM
bptjm-67	11	3	:	:	PUNCT
bptjm-67	11	4	dynasim	dynasim	PROPN
bptjm-67	11	5	projection	projection	NOUN
bptjm-67	11	6	of	of	ADP
bptjm-67	11	7	adults	adult	NOUN
bptjm-67	11	8	with	with	ADP
bptjm-67	11	9	cognitive	cognitive	ADJ
bptjm-67	11	10	impairments	impairment	NOUN
bptjm-67	11	11	from	from	ADP
bptjm-67	11	12	2020	2020	NUM
bptjm-67	11	13	to	to	ADP
bptjm-67	11	14	2060	2060	NUM
bptjm-67	11	15	cognitive	cognitive	ADJ
bptjm-67	11	16	decline	decline	NOUN
bptjm-67	11	17	encompasses	encompass	VERB
bptjm-67	11	18	a	a	DET
bptjm-67	11	19	range	range	NOUN
bptjm-67	11	20	of	of	ADP
bptjm-67	11	21	conditions	condition	NOUN
bptjm-67	11	22	,	,	PUNCT
bptjm-67	11	23	including	include	VERB
bptjm-67	11	24	common	common	ADJ
bptjm-67	11	25	neurodegenerative	neurodegenerative	ADJ
bptjm-67	11	26	diseases	disease	NOUN
bptjm-67	11	27	such	such	ADJ
bptjm-67	11	28	as	as	ADP
bptjm-67	11	29	alzheimer	alzheimer	PROPN
bptjm-67	11	30	’s	’s	PART
bptjm-67	11	31	disease	disease	NOUN
bptjm-67	11	32	(	(	PUNCT
bptjm-67	11	33	ad	ad	NOUN
bptjm-67	11	34	)	)	PUNCT
bptjm-67	11	35	,	,	PUNCT
bptjm-67	11	36	parkinson	parkinson	NOUN
bptjm-67	11	37	’s	’s	PART
bptjm-67	11	38	disease	disease	NOUN
bptjm-67	11	39	,	,	PUNCT
bptjm-67	11	40	and	and	CCONJ
bptjm-67	11	41	various	various	ADJ
bptjm-67	11	42	forms	form	NOUN
bptjm-67	11	43	of	of	ADP
bptjm-67	11	44	dementia	dementia	NOUN
bptjm-67	11	45	.	.	PUNCT
bptjm-67	12	1	ad	ad	NOUN
bptjm-67	12	2	,	,	PUNCT
bptjm-67	12	3	for	for	ADP
bptjm-67	12	4	example	example	NOUN
bptjm-67	12	5	,	,	PUNCT
bptjm-67	12	6	involves	involve	VERB
bptjm-67	12	7	impairments	impairment	NOUN
bptjm-67	12	8	across	across	ADP
bptjm-67	12	9	multiple	multiple	ADJ
bptjm-67	12	10	cognitive	cognitive	ADJ
bptjm-67	12	11	domains	domain	NOUN
bptjm-67	12	12	,	,	PUNCT
bptjm-67	12	13	affecting	affect	VERB
bptjm-67	12	14	memory	memory	NOUN
bptjm-67	12	15	,	,	PUNCT
bptjm-67	12	16	reasoning	reasoning	NOUN
bptjm-67	12	17	,	,	PUNCT
bptjm-67	12	18	language	language	NOUN
bptjm-67	12	19	,	,	PUNCT
bptjm-67	12	20	coordination	coordination	NOUN
bptjm-67	12	21	,	,	PUNCT
bptjm-67	12	22	mood	mood	NOUN
bptjm-67	12	23	,	,	PUNCT
bptjm-67	12	24	and	and	CCONJ
bptjm-67	12	25	behavior.4	behavior.4	ADV
bptjm-67	12	26	similarly	similarly	ADV
bptjm-67	12	27	,	,	PUNCT
bptjm-67	12	28	parkinson	parkinson	NOUN
bptjm-67	12	29	’s	’s	PART
bptjm-67	12	30	disease	disease	NOUN
bptjm-67	12	31	presents	present	VERB
bptjm-67	12	32	a	a	DET
bptjm-67	12	33	range	range	NOUN
bptjm-67	12	34	of	of	ADP
bptjm-67	12	35	non	non	ADJ
bptjm-67	12	36	-	-	ADJ
bptjm-67	12	37	motor	motor	ADJ
bptjm-67	12	38	and	and	CCONJ
bptjm-67	12	39	motor	motor	NOUN
bptjm-67	12	40	symptoms	symptom	NOUN
bptjm-67	12	41	,	,	PUNCT
bptjm-67	12	42	including	include	VERB
bptjm-67	12	43	a	a	DET
bptjm-67	12	44	diminished	diminished	ADJ
bptjm-67	12	45	sense	sense	NOUN
bptjm-67	12	46	of	of	ADP
bptjm-67	12	47	smell	smell	NOUN
bptjm-67	12	48	,	,	PUNCT
bptjm-67	12	49	digestive	digestive	ADJ
bptjm-67	12	50	issues	issue	NOUN
bptjm-67	12	51	,	,	PUNCT
bptjm-67	12	52	and	and	CCONJ
bptjm-67	12	53	drooling	drool	VERB
bptjm-67	12	54	,	,	PUNCT
bptjm-67	12	55	berkeley	berkeley	PROPN
bptjm-67	12	56	pharma	pharma	PROPN
bptjm-67	12	57	tech	tech	NOUN
bptjm-67	12	58	journal	journal	NOUN
bptjm-67	12	59	of	of	ADP
bptjm-67	12	60	medicine	medicine	NOUN
bptjm-67	12	61	|	|	ADV
bptjm-67	12	62	122	122	NUM
bptjm-67	12	63	alongside	alongside	ADP
bptjm-67	12	64	difficulties	difficulty	NOUN
bptjm-67	12	65	in	in	ADP
bptjm-67	12	66	executing	execute	VERB
bptjm-67	12	67	normal	normal	ADJ
bptjm-67	12	68	movements	movement	NOUN
bptjm-67	12	69	,	,	PUNCT
bptjm-67	12	70	experiencing	experience	VERB
bptjm-67	12	71	tremors	tremor	NOUN
bptjm-67	12	72	,	,	PUNCT
bptjm-67	12	73	and	and	CCONJ
bptjm-67	12	74	maintaining	maintain	VERB
bptjm-67	12	75	a	a	DET
bptjm-67	12	76	stable	stable	ADJ
bptjm-67	12	77	walking	walking	NOUN
bptjm-67	12	78	posture.5	posture.5	NOUN
bptjm-67	12	79	dementia	dementia	NOUN
bptjm-67	12	80	is	be	AUX
bptjm-67	12	81	a	a	DET
bptjm-67	12	82	broader	broad	ADJ
bptjm-67	12	83	term	term	NOUN
bptjm-67	12	84	that	that	PRON
bptjm-67	12	85	refers	refer	VERB
bptjm-67	12	86	to	to	ADP
bptjm-67	12	87	the	the	DET
bptjm-67	12	88	progressive	progressive	ADJ
bptjm-67	12	89	deterioration	deterioration	NOUN
bptjm-67	12	90	of	of	ADP
bptjm-67	12	91	memory	memory	NOUN
bptjm-67	12	92	and	and	CCONJ
bptjm-67	12	93	other	other	ADJ
bptjm-67	12	94	cognitive	cognitive	ADJ
bptjm-67	12	95	functions	function	NOUN
bptjm-67	12	96	,	,	PUNCT
bptjm-67	12	97	significantly	significantly	ADV
bptjm-67	12	98	interfering	interfere	VERB
bptjm-67	12	99	with	with	ADP
bptjm-67	12	100	an	an	DET
bptjm-67	12	101	individual	individual	NOUN
bptjm-67	12	102	’s	’s	PART
bptjm-67	12	103	ability	ability	NOUN
bptjm-67	12	104	to	to	PART
bptjm-67	12	105	perform	perform	VERB
bptjm-67	12	106	daily	daily	ADJ
bptjm-67	12	107	activities	activity	NOUN
bptjm-67	12	108	.	.	PUNCT
bptjm-67	13	1	6	6	NUM
bptjm-67	13	2	collectively	collectively	ADV
bptjm-67	13	3	,	,	PUNCT
bptjm-67	13	4	these	these	DET
bptjm-67	13	5	conditions	condition	NOUN
bptjm-67	13	6	underscore	underscore	VERB
bptjm-67	13	7	the	the	DET
bptjm-67	13	8	multifaceted	multifaceted	ADJ
bptjm-67	13	9	nature	nature	NOUN
bptjm-67	13	10	of	of	ADP
bptjm-67	13	11	cognitive	cognitive	ADJ
bptjm-67	13	12	decline	decline	NOUN
bptjm-67	13	13	and	and	CCONJ
bptjm-67	13	14	emphasize	emphasize	VERB
bptjm-67	13	15	the	the	DET
bptjm-67	13	16	need	need	NOUN
bptjm-67	13	17	to	to	PART
bptjm-67	13	18	address	address	VERB
bptjm-67	13	19	these	these	DET
bptjm-67	13	20	diseases	disease	NOUN
bptjm-67	13	21	.	.	PUNCT
bptjm-67	14	1	as	as	SCONJ
bptjm-67	14	2	cognitive	cognitive	ADJ
bptjm-67	14	3	decline	decline	NOUN
bptjm-67	14	4	progresses	progress	NOUN
bptjm-67	14	5	,	,	PUNCT
bptjm-67	14	6	impairments	impairment	NOUN
bptjm-67	14	7	in	in	ADP
bptjm-67	14	8	neuronal	neuronal	ADJ
bptjm-67	14	9	activity	activity	NOUN
bptjm-67	14	10	can	can	AUX
bptjm-67	14	11	lead	lead	VERB
bptjm-67	14	12	to	to	ADP
bptjm-67	14	13	inadequate	inadequate	ADJ
bptjm-67	14	14	perfusion	perfusion	NOUN
bptjm-67	14	15	of	of	ADP
bptjm-67	14	16	vital	vital	ADJ
bptjm-67	14	17	brain	brain	NOUN
bptjm-67	14	18	regions	region	NOUN
bptjm-67	14	19	,	,	PUNCT
bptjm-67	14	20	one	one	NUM
bptjm-67	14	21	of	of	ADP
bptjm-67	14	22	the	the	DET
bptjm-67	14	23	main	main	ADJ
bptjm-67	14	24	causes	cause	NOUN
bptjm-67	14	25	of	of	ADP
bptjm-67	14	26	neuronal	neuronal	ADJ
bptjm-67	14	27	damage	damage	NOUN
bptjm-67	14	28	and	and	CCONJ
bptjm-67	14	29	cognitive	cognitive	ADJ
bptjm-67	14	30	impairments	impairment	NOUN
bptjm-67	14	31	.	.	PUNCT
bptjm-67	15	1	therefore	therefore	ADV
bptjm-67	15	2	,	,	PUNCT
bptjm-67	15	3	understanding	understand	VERB
bptjm-67	15	4	the	the	DET
bptjm-67	15	5	interplay	interplay	NOUN
bptjm-67	15	6	between	between	ADP
bptjm-67	15	7	cognitive	cognitive	ADJ
bptjm-67	15	8	decline	decline	NOUN
bptjm-67	15	9	and	and	CCONJ
bptjm-67	15	10	neurovascular	neurovascular	ADJ
bptjm-67	15	11	coupling	coupling	NOUN
bptjm-67	15	12	is	be	AUX
bptjm-67	15	13	crucial	crucial	ADJ
bptjm-67	15	14	for	for	ADP
bptjm-67	15	15	developing	develop	VERB
bptjm-67	15	16	effective	effective	ADJ
bptjm-67	15	17	strategies	strategy	NOUN
bptjm-67	15	18	to	to	PART
bptjm-67	15	19	preserve	preserve	VERB
bptjm-67	15	20	brain	brain	NOUN
bptjm-67	15	21	function	function	NOUN
bptjm-67	15	22	and	and	CCONJ
bptjm-67	15	23	slow	slow	VERB
bptjm-67	15	24	the	the	DET
bptjm-67	15	25	progression	progression	NOUN
bptjm-67	15	26	of	of	ADP
bptjm-67	15	27	neurodegenerative	neurodegenerative	ADJ
bptjm-67	15	28	diseases	disease	NOUN
bptjm-67	15	29	.	.	PUNCT
bptjm-67	16	1	1.2	1.2	NUM
bptjm-67	16	2	neurovascular	neurovascular	ADJ
bptjm-67	16	3	coupling	coupling	NOUN
bptjm-67	16	4	nvc	nvc	NOUN
bptjm-67	16	5	refers	refer	VERB
bptjm-67	16	6	to	to	ADP
bptjm-67	16	7	the	the	DET
bptjm-67	16	8	process	process	NOUN
bptjm-67	16	9	by	by	ADP
bptjm-67	16	10	which	which	PRON
bptjm-67	16	11	the	the	DET
bptjm-67	16	12	metabolic	metabolic	NOUN
bptjm-67	16	13	demands	demand	NOUN
bptjm-67	16	14	of	of	ADP
bptjm-67	16	15	active	active	ADJ
bptjm-67	16	16	neurons	neuron	NOUN
bptjm-67	16	17	trigger	trigger	NOUN
bptjm-67	16	18	localized	localize	VERB
bptjm-67	16	19	changes	change	NOUN
bptjm-67	16	20	in	in	ADP
bptjm-67	16	21	cerebrovascular	cerebrovascular	ADJ
bptjm-67	16	22	blood	blood	NOUN
bptjm-67	16	23	flow	flow	NOUN
bptjm-67	16	24	(	(	PUNCT
bptjm-67	16	25	cbf	cbf	PROPN
bptjm-67	16	26	)	)	PUNCT
bptjm-67	16	27	.	.	PUNCT
bptjm-67	17	1	this	this	DET
bptjm-67	17	2	mechanism	mechanism	NOUN
bptjm-67	17	3	ensures	ensure	VERB
bptjm-67	17	4	that	that	SCONJ
bptjm-67	17	5	the	the	DET
bptjm-67	17	6	brain	brain	NOUN
bptjm-67	17	7	receives	receive	VERB
bptjm-67	17	8	adequate	adequate	ADJ
bptjm-67	17	9	oxygen	oxygen	NOUN
bptjm-67	17	10	and	and	CCONJ
bptjm-67	17	11	nutrients	nutrient	NOUN
bptjm-67	17	12	during	during	ADP
bptjm-67	17	13	periods	period	NOUN
bptjm-67	17	14	of	of	ADP
bptjm-67	17	15	increased	increase	VERB
bptjm-67	17	16	neural	neural	ADJ
bptjm-67	17	17	activity	activity	NOUN
bptjm-67	17	18	,	,	PUNCT
bptjm-67	17	19	thereby	thereby	ADV
bptjm-67	17	20	maintaining	maintain	VERB
bptjm-67	17	21	optimal	optimal	ADJ
bptjm-67	17	22	perfusion	perfusion	NOUN
bptjm-67	17	23	in	in	ADP
bptjm-67	17	24	response	response	NOUN
bptjm-67	17	25	to	to	ADP
bptjm-67	17	26	fluctuating	fluctuate	VERB
bptjm-67	17	27	neuronal	neuronal	ADJ
bptjm-67	17	28	demands.7	demands.7	NOUN
bptjm-67	17	29	1.2.1	1.2.1	NUM
bptjm-67	17	30	neurovascular	neurovascular	ADJ
bptjm-67	17	31	unit	unit	NOUN
bptjm-67	17	32	the	the	DET
bptjm-67	17	33	regulation	regulation	NOUN
bptjm-67	17	34	of	of	ADP
bptjm-67	17	35	nvc	nvc	NOUN
bptjm-67	17	36	is	be	AUX
bptjm-67	17	37	coordinated	coordinate	VERB
bptjm-67	17	38	by	by	ADP
bptjm-67	17	39	the	the	DET
bptjm-67	17	40	neurovascular	neurovascular	ADJ
bptjm-67	17	41	unit	unit	NOUN
bptjm-67	17	42	(	(	PUNCT
bptjm-67	17	43	nvu	nvu	NOUN
bptjm-67	17	44	)	)	PUNCT
bptjm-67	17	45	,	,	PUNCT
bptjm-67	17	46	a	a	DET
bptjm-67	17	47	complex	complex	ADJ
bptjm-67	17	48	assembly	assembly	NOUN
bptjm-67	17	49	of	of	ADP
bptjm-67	17	50	neurons	neuron	NOUN
bptjm-67	17	51	,	,	PUNCT
bptjm-67	17	52	glial	glial	ADJ
bptjm-67	17	53	cells	cell	NOUN
bptjm-67	17	54	,	,	PUNCT
bptjm-67	17	55	and	and	CCONJ
bptjm-67	17	56	vascular	vascular	ADJ
bptjm-67	17	57	cells	cell	NOUN
bptjm-67	17	58	.	.	PUNCT
bptjm-67	18	1	glial	glial	ADJ
bptjm-67	18	2	cells	cell	NOUN
bptjm-67	18	3	—	—	PUNCT
bptjm-67	18	4	such	such	ADJ
bptjm-67	18	5	as	as	ADP
bptjm-67	18	6	astrocytes	astrocyte	NOUN
bptjm-67	18	7	and	and	CCONJ
bptjm-67	18	8	microglia	microglia	ADJ
bptjm-67	18	9	—	—	PUNCT
bptjm-67	18	10	play	play	VERB
bptjm-67	18	11	essential	essential	ADJ
bptjm-67	18	12	roles	role	NOUN
bptjm-67	18	13	in	in	ADP
bptjm-67	18	14	supporting	support	VERB
bptjm-67	18	15	and	and	CCONJ
bptjm-67	18	16	protecting	protect	VERB
bptjm-67	18	17	neurons	neuron	NOUN
bptjm-67	18	18	.	.	PUNCT
bptjm-67	19	1	they	they	PRON
bptjm-67	19	2	also	also	ADV
bptjm-67	19	3	contribute	contribute	VERB
bptjm-67	19	4	to	to	ADP
bptjm-67	19	5	vasculogenesis	vasculogenesis	NOUN
bptjm-67	19	6	(	(	PUNCT
bptjm-67	19	7	the	the	DET
bptjm-67	19	8	formation	formation	NOUN
bptjm-67	19	9	of	of	ADP
bptjm-67	19	10	new	new	ADJ
bptjm-67	19	11	blood	blood	NOUN
bptjm-67	19	12	vessels	vessel	NOUN
bptjm-67	19	13	from	from	ADP
bptjm-67	19	14	endothelial	endothelial	ADJ
bptjm-67	19	15	progenitor	progenitor	NOUN
bptjm-67	19	16	cells	cell	NOUN
bptjm-67	19	17	)	)	PUNCT
bptjm-67	19	18	and	and	CCONJ
bptjm-67	19	19	the	the	DET
bptjm-67	19	20	development	development	NOUN
bptjm-67	19	21	of	of	ADP
bptjm-67	19	22	synapses.8	synapses.8	ADJ
bptjm-67	19	23	vascular	vascular	ADJ
bptjm-67	19	24	cells	cell	NOUN
bptjm-67	19	25	,	,	PUNCT
bptjm-67	19	26	including	include	VERB
bptjm-67	19	27	endothelial	endothelial	ADJ
bptjm-67	19	28	cells	cell	NOUN
bptjm-67	19	29	,	,	PUNCT
bptjm-67	19	30	help	help	VERB
bptjm-67	19	31	maintain	maintain	VERB
bptjm-67	19	32	the	the	DET
bptjm-67	19	33	blood	blood	NOUN
bptjm-67	19	34	-	-	PUNCT
bptjm-67	19	35	brain	brain	NOUN
bptjm-67	19	36	barrier	barrier	NOUN
bptjm-67	19	37	(	(	PUNCT
bptjm-67	19	38	bbb	bbb	NOUN
bptjm-67	19	39	)	)	PUNCT
bptjm-67	19	40	,	,	PUNCT
bptjm-67	19	41	sense	sense	VERB
bptjm-67	19	42	mechanical	mechanical	ADJ
bptjm-67	19	43	and	and	CCONJ
bptjm-67	19	44	hormonal	hormonal	ADJ
bptjm-67	19	45	signals	signal	NOUN
bptjm-67	19	46	to	to	PART
bptjm-67	19	47	regulate	regulate	VERB
bptjm-67	19	48	cbf	cbf	PROPN
bptjm-67	19	49	.	.	PUNCT
bptjm-67	20	1	these	these	DET
bptjm-67	20	2	cells	cell	NOUN
bptjm-67	20	3	also	also	ADV
bptjm-67	20	4	release	release	VERB
bptjm-67	20	5	substances	substance	NOUN
bptjm-67	20	6	,	,	PUNCT
bptjm-67	20	7	like	like	ADP
bptjm-67	20	8	proteoglycans	proteoglycan	NOUN
bptjm-67	20	9	and	and	CCONJ
bptjm-67	20	10	glycoproteins	glycoprotein	NOUN
bptjm-67	20	11	,	,	PUNCT
bptjm-67	20	12	to	to	PART
bptjm-67	20	13	adapt	adapt	VERB
bptjm-67	20	14	blood	blood	NOUN
bptjm-67	20	15	flow	flow	NOUN
bptjm-67	20	16	accordingly	accordingly	ADV
bptjm-67	20	17	.	.	PUNCT
bptjm-67	21	1	vascular	vascular	ADJ
bptjm-67	21	2	smooth	smooth	ADJ
bptjm-67	21	3	muscle	muscle	NOUN
bptjm-67	21	4	cells	cell	NOUN
bptjm-67	21	5	adjust	adjust	VERB
bptjm-67	21	6	cbf	cbf	PROPN
bptjm-67	21	7	by	by	ADP
bptjm-67	21	8	modulating	modulate	VERB
bptjm-67	21	9	vascular	vascular	ADJ
bptjm-67	21	10	tone	tone	NOUN
bptjm-67	21	11	and	and	CCONJ
bptjm-67	21	12	capillary	capillary	ADJ
bptjm-67	21	13	diameter	diameter	NOUN
bptjm-67	21	14	in	in	ADP
bptjm-67	21	15	response	response	NOUN
bptjm-67	21	16	to	to	ADP
bptjm-67	21	17	signals	signal	NOUN
bptjm-67	21	18	from	from	ADP
bptjm-67	21	19	endothelial	endothelial	ADJ
bptjm-67	21	20	cells	cell	NOUN
bptjm-67	21	21	.	.	PUNCT
bptjm-67	22	1	likewise	likewise	ADV
bptjm-67	22	2	,	,	PUNCT
bptjm-67	22	3	pericytes	pericyte	NOUN
bptjm-67	22	4	influence	influence	PROPN
bptjm-67	22	5	cbf	cbf	PROPN
bptjm-67	22	6	by	by	ADP
bptjm-67	22	7	altering	alter	VERB
bptjm-67	22	8	capillary	capillary	ADJ
bptjm-67	22	9	diameter	diameter	NOUN
bptjm-67	22	10	in	in	ADP
bptjm-67	22	11	response	response	NOUN
bptjm-67	22	12	to	to	ADP
bptjm-67	22	13	neurotransmitters	neurotransmitter	NOUN
bptjm-67	22	14	such	such	ADJ
bptjm-67	22	15	as	as	ADP
bptjm-67	22	16	noradrenaline	noradrenaline	ADJ
bptjm-67	22	17	and	and	CCONJ
bptjm-67	22	18	glutamate	glutamate	NOUN
bptjm-67	22	19	.	.	PUNCT
bptjm-67	23	1	this	this	DET
bptjm-67	23	2	interconnected	interconnected	ADJ
bptjm-67	23	3	network	network	NOUN
bptjm-67	23	4	ensures	ensure	VERB
bptjm-67	23	5	the	the	DET
bptjm-67	23	6	delivery	delivery	NOUN
bptjm-67	23	7	of	of	ADP
bptjm-67	23	8	essential	essential	ADJ
bptjm-67	23	9	nutrients	nutrient	NOUN
bptjm-67	23	10	,	,	PUNCT
bptjm-67	23	11	such	such	ADJ
bptjm-67	23	12	asglucose	asglucose	ADJ
bptjm-67	23	13	and	and	CCONJ
bptjm-67	23	14	oxygen	oxygen	NOUN
bptjm-67	23	15	,	,	PUNCT
bptjm-67	23	16	to	to	PART
bptjm-67	23	17	sustain	sustain	VERB
bptjm-67	23	18	the	the	DET
bptjm-67	23	19	berkeley	berkeley	PROPN
bptjm-67	23	20	pharma	pharma	PROPN
bptjm-67	23	21	tech	tech	NOUN
bptjm-67	23	22	journal	journal	NOUN
bptjm-67	23	23	of	of	ADP
bptjm-67	23	24	medicine	medicine	NOUN
bptjm-67	23	25	|	|	ADV
bptjm-67	23	26	123	123	NUM
bptjm-67	23	27	energy	energy	NOUN
bptjm-67	23	28	-	-	PUNCT
bptjm-67	23	29	demanding	demand	VERB
bptjm-67	23	30	brain	brain	NOUN
bptjm-67	23	31	activity	activity	NOUN
bptjm-67	23	32	,	,	PUNCT
bptjm-67	23	33	while	while	SCONJ
bptjm-67	23	34	also	also	ADV
bptjm-67	23	35	maintaining	maintain	VERB
bptjm-67	23	36	cerebrovascular	cerebrovascular	ADJ
bptjm-67	23	37	homeostasis.9	homeostasis.9	NOUN
bptjm-67	23	38	figure	figure	NOUN
bptjm-67	23	39	2	2	NUM
bptjm-67	23	40	:	:	PUNCT
bptjm-67	23	41	neurovascular	neurovascular	ADJ
bptjm-67	23	42	coupling	coupling	NOUN
bptjm-67	23	43	mechanism	mechanism	NOUN
bptjm-67	23	44	.	.	PUNCT
bptjm-67	24	1	stimulation	stimulation	NOUN
bptjm-67	24	2	triggers	trigger	VERB
bptjm-67	24	3	glutamate	glutamate	ADJ
bptjm-67	24	4	secretion	secretion	NOUN
bptjm-67	24	5	,	,	PUNCT
bptjm-67	24	6	activating	activate	VERB
bptjm-67	24	7	neurons	neuron	NOUN
bptjm-67	24	8	and	and	CCONJ
bptjm-67	24	9	astrocytes	astrocyte	NOUN
bptjm-67	24	10	to	to	PART
bptjm-67	24	11	release	release	VERB
bptjm-67	24	12	nitric	nitric	ADJ
bptjm-67	24	13	oxide	oxide	NOUN
bptjm-67	24	14	(	(	PUNCT
bptjm-67	24	15	no	no	NOUN
bptjm-67	24	16	)	)	PUNCT
bptjm-67	24	17	,	,	PUNCT
bptjm-67	24	18	potassium	potassium	NOUN
bptjm-67	24	19	(	(	PUNCT
bptjm-67	24	20	k+	k+	NOUN
bptjm-67	24	21	)	)	PUNCT
bptjm-67	24	22	,	,	PUNCT
bptjm-67	24	23	adenosine	adenosine	NOUN
bptjm-67	24	24	(	(	PUNCT
bptjm-67	24	25	ado	ado	NOUN
bptjm-67	24	26	)	)	PUNCT
bptjm-67	24	27	,	,	PUNCT
bptjm-67	24	28	epoxyeicosatrienoic	epoxyeicosatrienoic	ADJ
bptjm-67	24	29	acids	acid	NOUN
bptjm-67	24	30	(	(	PUNCT
bptjm-67	24	31	eet	eet	X
bptjm-67	24	32	)	)	PUNCT
bptjm-67	24	33	,	,	PUNCT
bptjm-67	24	34	and	and	CCONJ
bptjm-67	24	35	prostaglandins	prostaglandin	NOUN
bptjm-67	24	36	(	(	PUNCT
bptjm-67	24	37	pge2	pge2	NOUN
bptjm-67	24	38	)	)	PUNCT
bptjm-67	24	39	,	,	PUNCT
bptjm-67	24	40	leading	lead	VERB
bptjm-67	24	41	to	to	ADP
bptjm-67	24	42	arteriolar	arteriolar	ADJ
bptjm-67	24	43	vasodilation	vasodilation	NOUN
bptjm-67	24	44	.	.	PUNCT
bptjm-67	25	1	astrocytes	astrocyte	NOUN
bptjm-67	25	2	also	also	ADV
bptjm-67	25	3	release	release	VERB
bptjm-67	25	4	arachidonic	arachidonic	ADJ
bptjm-67	25	5	acid	acid	NOUN
bptjm-67	25	6	(	(	PUNCT
bptjm-67	25	7	aa	aa	NOUN
bptjm-67	25	8	)	)	PUNCT
bptjm-67	25	9	,	,	PUNCT
bptjm-67	25	10	causing	cause	VERB
bptjm-67	25	11	vasoconstriction	vasoconstriction	NOUN
bptjm-67	25	12	,	,	PUNCT
bptjm-67	25	13	and	and	CCONJ
bptjm-67	25	14	pericytes	pericyte	NOUN
bptjm-67	25	15	are	be	AUX
bptjm-67	25	16	stimulated	stimulate	VERB
bptjm-67	25	17	separately	separately	ADV
bptjm-67	25	18	,	,	PUNCT
bptjm-67	25	19	leading	lead	VERB
bptjm-67	25	20	to	to	ADP
bptjm-67	25	21	capillary	capillary	ADJ
bptjm-67	25	22	dilation	dilation	NOUN
bptjm-67	25	23	.	.	PUNCT
bptjm-67	26	1	berkeley	berkeley	PROPN
bptjm-67	26	2	pharma	pharma	PROPN
bptjm-67	26	3	tech	tech	PROPN
bptjm-67	26	4	journal	journal	NOUN
bptjm-67	26	5	of	of	ADP
bptjm-67	26	6	medicine	medicine	NOUN
bptjm-67	26	7	|	|	ADV
bptjm-67	26	8	124	124	NUM
bptjm-67	26	9	figure	figure	NOUN
bptjm-67	26	10	3	3	NUM
bptjm-67	26	11	:	:	PUNCT
bptjm-67	26	12	the	the	DET
bptjm-67	26	13	neurovascular	neurovascular	ADJ
bptjm-67	26	14	unit	unit	NOUN
bptjm-67	26	15	.	.	PUNCT
bptjm-67	27	1	the	the	DET
bptjm-67	27	2	neurovascular	neurovascular	ADJ
bptjm-67	27	3	unit	unit	NOUN
bptjm-67	27	4	(	(	PUNCT
bptjm-67	27	5	nvu	nvu	NOUN
bptjm-67	27	6	)	)	PUNCT
bptjm-67	27	7	consists	consist	VERB
bptjm-67	27	8	of	of	ADP
bptjm-67	27	9	endothelial	endothelial	ADJ
bptjm-67	27	10	cells	cell	NOUN
bptjm-67	27	11	,	,	PUNCT
bptjm-67	27	12	pericytes	pericyte	NOUN
bptjm-67	27	13	,	,	PUNCT
bptjm-67	27	14	astrocytes	astrocyte	NOUN
bptjm-67	27	15	,	,	PUNCT
bptjm-67	27	16	neurons	neuron	NOUN
bptjm-67	27	17	,	,	PUNCT
bptjm-67	27	18	and	and	CCONJ
bptjm-67	27	19	the	the	DET
bptjm-67	27	20	extracellular	extracellular	ADJ
bptjm-67	27	21	matrix	matrix	NOUN
bptjm-67	27	22	.	.	PUNCT
bptjm-67	28	1	the	the	DET
bptjm-67	28	2	nvu	nvu	NOUN
bptjm-67	28	3	balances	balance	VERB
bptjm-67	28	4	the	the	DET
bptjm-67	28	5	brain	brain	NOUN
bptjm-67	28	6	microenvironment	microenvironment	NOUN
bptjm-67	28	7	,	,	PUNCT
bptjm-67	28	8	regulates	regulate	VERB
bptjm-67	28	9	cerebral	cerebral	ADJ
bptjm-67	28	10	blood	blood	NOUN
bptjm-67	28	11	flow	flow	NOUN
bptjm-67	28	12	,	,	PUNCT
bptjm-67	28	13	facilitates	facilitate	VERB
bptjm-67	28	14	immune	immune	ADJ
bptjm-67	28	15	cell	cell	NOUN
bptjm-67	28	16	movement	movement	NOUN
bptjm-67	28	17	,	,	PUNCT
bptjm-67	28	18	produces	produce	VERB
bptjm-67	28	19	growth	growth	NOUN
bptjm-67	28	20	factors	factor	NOUN
bptjm-67	28	21	for	for	ADP
bptjm-67	28	22	cell	cell	NOUN
bptjm-67	28	23	survival	survival	NOUN
bptjm-67	28	24	,	,	PUNCT
bptjm-67	28	25	and	and	CCONJ
bptjm-67	28	26	aids	aid	NOUN
bptjm-67	28	27	in	in	ADP
bptjm-67	28	28	clearing	clear	VERB
bptjm-67	28	29	harmful	harmful	ADJ
bptjm-67	28	30	brain	brain	NOUN
bptjm-67	28	31	byproducts	byproduct	NOUN
bptjm-67	28	32	,	,	PUNCT
bptjm-67	28	33	crucial	crucial	ADJ
bptjm-67	28	34	for	for	ADP
bptjm-67	28	35	brain	brain	NOUN
bptjm-67	28	36	health	health	NOUN
bptjm-67	28	37	.	.	PUNCT
bptjm-67	29	1	berkeley	berkeley	PROPN
bptjm-67	29	2	pharma	pharma	PROPN
bptjm-67	29	3	tech	tech	PROPN
bptjm-67	29	4	journal	journal	NOUN
bptjm-67	29	5	of	of	ADP
bptjm-67	29	6	medicine	medicine	NOUN
bptjm-67	29	7	|	|	ADV
bptjm-67	29	8	125	125	NUM
bptjm-67	29	9	figure	figure	NOUN
bptjm-67	29	10	4	4	NUM
bptjm-67	29	11	:	:	PUNCT
bptjm-67	29	12	the	the	DET
bptjm-67	29	13	blood	blood	NOUN
bptjm-67	29	14	-	-	PUNCT
bptjm-67	29	15	brain	brain	NOUN
bptjm-67	29	16	barrier	barrier	NOUN
bptjm-67	29	17	.	.	PUNCT
bptjm-67	30	1	vascular	vascular	ADJ
bptjm-67	30	2	stresses	stress	NOUN
bptjm-67	30	3	affect	affect	VERB
bptjm-67	30	4	the	the	DET
bptjm-67	30	5	blood	blood	NOUN
bptjm-67	30	6	-	-	PUNCT
bptjm-67	30	7	brain	brain	NOUN
bptjm-67	30	8	barrier	barrier	NOUN
bptjm-67	30	9	,	,	PUNCT
bptjm-67	30	10	which	which	PRON
bptjm-67	30	11	regulates	regulate	VERB
bptjm-67	30	12	brain	brain	NOUN
bptjm-67	30	13	perfusion	perfusion	NOUN
bptjm-67	30	14	.	.	PUNCT
bptjm-67	31	1	conditions	condition	NOUN
bptjm-67	31	2	like	like	ADP
bptjm-67	31	3	hypertension	hypertension	NOUN
bptjm-67	31	4	damage	damage	VERB
bptjm-67	31	5	the	the	DET
bptjm-67	31	6	endothelium	endothelium	NOUN
bptjm-67	31	7	,	,	PUNCT
bptjm-67	31	8	disrupting	disrupt	VERB
bptjm-67	31	9	the	the	DET
bptjm-67	31	10	blood	blood	NOUN
bptjm-67	31	11	-	-	PUNCT
bptjm-67	31	12	brain	brain	NOUN
bptjm-67	31	13	barrier	barrier	NOUN
bptjm-67	31	14	,	,	PUNCT
bptjm-67	31	15	causing	cause	VERB
bptjm-67	31	16	microhemorrhages	microhemorrhage	NOUN
bptjm-67	31	17	,	,	PUNCT
bptjm-67	31	18	inflammation	inflammation	NOUN
bptjm-67	31	19	,	,	PUNCT
bptjm-67	31	20	and	and	CCONJ
bptjm-67	31	21	neuronal	neuronal	ADJ
bptjm-67	31	22	injury	injury	NOUN
bptjm-67	31	23	.	.	PUNCT
bptjm-67	32	1	this	this	DET
bptjm-67	32	2	process	process	NOUN
bptjm-67	32	3	contributes	contribute	VERB
bptjm-67	32	4	to	to	ADP
bptjm-67	32	5	cognitive	cognitive	ADJ
bptjm-67	32	6	decline	decline	NOUN
bptjm-67	32	7	and	and	CCONJ
bptjm-67	32	8	dementia	dementia	NOUN
bptjm-67	32	9	.	.	PUNCT
bptjm-67	33	1	1.3	1.3	NUM
bptjm-67	33	2	purpose	purpose	NOUN
bptjm-67	33	3	of	of	ADP
bptjm-67	33	4	study	study	NOUN
bptjm-67	33	5	building	build	VERB
bptjm-67	33	6	upon	upon	SCONJ
bptjm-67	33	7	our	our	PRON
bptjm-67	33	8	review	review	NOUN
bptjm-67	33	9	of	of	ADP
bptjm-67	33	10	cognitive	cognitive	ADJ
bptjm-67	33	11	decline	decline	NOUN
bptjm-67	33	12	,	,	PUNCT
bptjm-67	33	13	we	we	PRON
bptjm-67	33	14	propose	propose	VERB
bptjm-67	33	15	that	that	SCONJ
bptjm-67	33	16	nvc	nvc	PROPN
bptjm-67	33	17	plays	play	VERB
bptjm-67	33	18	a	a	DET
bptjm-67	33	19	critical	critical	ADJ
bptjm-67	33	20	regulatory	regulatory	ADJ
bptjm-67	33	21	role	role	NOUN
bptjm-67	33	22	in	in	ADP
bptjm-67	33	23	neurovascular	neurovascular	ADJ
bptjm-67	33	24	diseases	disease	NOUN
bptjm-67	33	25	associated	associate	VERB
bptjm-67	33	26	with	with	ADP
bptjm-67	33	27	cognitive	cognitive	ADJ
bptjm-67	33	28	impairment	impairment	NOUN
bptjm-67	33	29	.	.	PUNCT
bptjm-67	34	1	this	this	DET
bptjm-67	34	2	study	study	NOUN
bptjm-67	34	3	aims	aim	VERB
bptjm-67	34	4	to	to	PART
bptjm-67	34	5	identify	identify	VERB
bptjm-67	34	6	early	early	ADJ
bptjm-67	34	7	signs	sign	NOUN
bptjm-67	34	8	of	of	ADP
bptjm-67	34	9	cognitive	cognitive	ADJ
bptjm-67	34	10	decline	decline	NOUN
bptjm-67	34	11	by	by	ADP
bptjm-67	34	12	targeting	target	VERB
bptjm-67	34	13	relevant	relevant	ADJ
bptjm-67	34	14	biomarkers	biomarker	NOUN
bptjm-67	34	15	and	and	CCONJ
bptjm-67	34	16	to	to	PART
bptjm-67	34	17	explore	explore	VERB
bptjm-67	34	18	treatment	treatment	NOUN
bptjm-67	34	19	options	option	NOUN
bptjm-67	34	20	for	for	ADP
bptjm-67	34	21	conditions	condition	NOUN
bptjm-67	34	22	linked	link	VERB
bptjm-67	34	23	to	to	ADP
bptjm-67	34	24	nvc	nvc	ADJ
bptjm-67	34	25	dysfunction	dysfunction	NOUN
bptjm-67	34	26	.	.	PUNCT
bptjm-67	35	1	specifically	specifically	ADV
bptjm-67	35	2	,	,	PUNCT
bptjm-67	35	3	we	we	PRON
bptjm-67	35	4	seek	seek	VERB
bptjm-67	35	5	to	to	PART
bptjm-67	35	6	understand	understand	VERB
bptjm-67	35	7	how	how	SCONJ
bptjm-67	35	8	changes	change	NOUN
bptjm-67	35	9	in	in	ADP
bptjm-67	35	10	neuronal	neuronal	ADJ
bptjm-67	35	11	activity	activity	NOUN
bptjm-67	35	12	affect	affect	VERB
bptjm-67	35	13	blood	blood	NOUN
bptjm-67	35	14	vessel	vessel	NOUN
bptjm-67	35	15	function	function	NOUN
bptjm-67	35	16	and	and	CCONJ
bptjm-67	35	17	cerebral	cerebral	ADJ
bptjm-67	35	18	blood	blood	NOUN
bptjm-67	35	19	flow	flow	NOUN
bptjm-67	35	20	(	(	PUNCT
bptjm-67	35	21	cbf	cbf	PROPN
bptjm-67	35	22	)	)	PUNCT
bptjm-67	35	23	in	in	ADP
bptjm-67	35	24	cognitive	cognitive	ADJ
bptjm-67	35	25	disorders	disorder	NOUN
bptjm-67	35	26	such	such	ADJ
bptjm-67	35	27	as	as	ADP
bptjm-67	35	28	ad	ad	NOUN
bptjm-67	35	29	,	,	PUNCT
bptjm-67	35	30	parkinson	parkinson	NOUN
bptjm-67	35	31	’s	’s	PART
bptjm-67	35	32	disease	disease	NOUN
bptjm-67	35	33	,	,	PUNCT
bptjm-67	35	34	and	and	CCONJ
bptjm-67	35	35	dementia	dementia	NOUN
bptjm-67	35	36	.	.	PUNCT
bptjm-67	36	1	2	2	X
bptjm-67	36	2	.	.	X
bptjm-67	36	3	histopathological	histopathological	ADJ
bptjm-67	36	4	features	feature	NOUN
bptjm-67	36	5	of	of	ADP
bptjm-67	36	6	nvc	nvc	NOUN
bptjm-67	36	7	-	-	PUNCT
bptjm-67	36	8	related	relate	VERB
bptjm-67	36	9	diseases	disease	NOUN
bptjm-67	36	10	histopathological	histopathological	ADJ
bptjm-67	36	11	markers	marker	NOUN
bptjm-67	36	12	of	of	ADP
bptjm-67	36	13	nvc	nvc	NOUN
bptjm-67	36	14	-	-	PUNCT
bptjm-67	36	15	related	relate	VERB
bptjm-67	36	16	diseases	disease	NOUN
bptjm-67	36	17	,	,	PUNCT
bptjm-67	36	18	including	include	VERB
bptjm-67	36	19	alzheimer	alzheimer	PROPN
bptjm-67	36	20	’s	’s	PART
bptjm-67	36	21	and	and	CCONJ
bptjm-67	36	22	vascular	vascular	ADJ
bptjm-67	36	23	dementia	dementia	NOUN
bptjm-67	36	24	,	,	PUNCT
bptjm-67	36	25	can	can	AUX
bptjm-67	36	26	be	be	AUX
bptjm-67	36	27	observed	observe	VERB
bptjm-67	36	28	through	through	ADP
bptjm-67	36	29	tissue	tissue	NOUN
bptjm-67	36	30	imaging	imaging	NOUN
bptjm-67	36	31	techniques	technique	NOUN
bptjm-67	36	32	.	.	PUNCT
bptjm-67	37	1	particularly	particularly	ADV
bptjm-67	37	2	,	,	PUNCT
bptjm-67	37	3	the	the	DET
bptjm-67	37	4	well	well	ADV
bptjm-67	37	5	-	-	PUNCT
bptjm-67	37	6	known	know	VERB
bptjm-67	37	7	biomarkers	biomarker	NOUN
bptjm-67	37	8	of	of	ADP
bptjm-67	37	9	neurofibrillary	neurofibrillary	ADJ
bptjm-67	37	10	tangles	tangle	NOUN
bptjm-67	37	11	and	and	CCONJ
bptjm-67	37	12	β	β	NOUN
bptjm-67	37	13	-	-	ADJ
bptjm-67	37	14	amyloid	amyloid	ADJ
bptjm-67	37	15	plaque	plaque	NOUN
bptjm-67	37	16	is	be	AUX
bptjm-67	37	17	associated	associate	VERB
bptjm-67	37	18	with	with	ADP
bptjm-67	37	19	alzheimer	alzheimer	PROPN
bptjm-67	37	20	’s	’s	PART
bptjm-67	37	21	,	,	PUNCT
bptjm-67	37	22	while	while	SCONJ
bptjm-67	37	23	neuronal	neuronal	ADJ
bptjm-67	37	24	tissue	tissue	NOUN
bptjm-67	37	25	death	death	NOUN
bptjm-67	37	26	and	and	CCONJ
bptjm-67	37	27	myelin	myelin	NOUN
bptjm-67	37	28	breakdown	breakdown	NOUN
bptjm-67	37	29	is	be	AUX
bptjm-67	37	30	associated	associate	VERB
bptjm-67	37	31	with	with	ADP
bptjm-67	37	32	vascular	vascular	NOUN
bptjm-67	37	33	dementia.10	dementia.10	NOUN
bptjm-67	37	34	it	it	PRON
bptjm-67	37	35	is	be	AUX
bptjm-67	37	36	berkeley	berkeley	PROPN
bptjm-67	37	37	pharma	pharma	PROPN
bptjm-67	37	38	tech	tech	NOUN
bptjm-67	37	39	journal	journal	NOUN
bptjm-67	37	40	of	of	ADP
bptjm-67	37	41	medicine	medicine	NOUN
bptjm-67	37	42	|	|	ADV
bptjm-67	37	43	126	126	NUM
bptjm-67	37	44	hypothesized	hypothesize	VERB
bptjm-67	37	45	that	that	SCONJ
bptjm-67	37	46	vascular	vascular	ADJ
bptjm-67	37	47	abnormalities	abnormality	NOUN
bptjm-67	37	48	contribute	contribute	VERB
bptjm-67	37	49	to	to	ADP
bptjm-67	37	50	the	the	DET
bptjm-67	37	51	early	early	ADJ
bptjm-67	37	52	progression	progression	NOUN
bptjm-67	37	53	of	of	ADP
bptjm-67	37	54	cognitive	cognitive	ADJ
bptjm-67	37	55	disorders	disorder	NOUN
bptjm-67	37	56	and	and	CCONJ
bptjm-67	37	57	precede	precede	VERB
bptjm-67	37	58	the	the	DET
bptjm-67	37	59	emergence	emergence	NOUN
bptjm-67	37	60	of	of	ADP
bptjm-67	37	61	these	these	DET
bptjm-67	37	62	histopathological	histopathological	ADJ
bptjm-67	37	63	features.11	features.11	NOUN
bptjm-67	37	64	for	for	ADP
bptjm-67	37	65	instance	instance	NOUN
bptjm-67	37	66	,	,	PUNCT
bptjm-67	37	67	one	one	NUM
bptjm-67	37	68	study	study	NOUN
bptjm-67	37	69	found	find	VERB
bptjm-67	37	70	that	that	SCONJ
bptjm-67	37	71	patients	patient	NOUN
bptjm-67	37	72	with	with	ADP
bptjm-67	37	73	vascular	vascular	ADJ
bptjm-67	37	74	dementia	dementia	NOUN
bptjm-67	37	75	have	have	VERB
bptjm-67	37	76	significant	significant	ADJ
bptjm-67	37	77	hippocampal	hippocampal	ADJ
bptjm-67	37	78	neuronal	neuronal	ADJ
bptjm-67	37	79	loss	loss	NOUN
bptjm-67	37	80	due	due	ADP
bptjm-67	37	81	to	to	ADP
bptjm-67	37	82	microvascular	microvascular	ADJ
bptjm-67	37	83	pathology.12	pathology.12	NOUN
bptjm-67	37	84	these	these	DET
bptjm-67	37	85	findings	finding	NOUN
bptjm-67	37	86	support	support	VERB
bptjm-67	37	87	a	a	DET
bptjm-67	37	88	correlation	correlation	NOUN
bptjm-67	37	89	between	between	ADP
bptjm-67	37	90	vascular	vascular	ADJ
bptjm-67	37	91	dysfunction	dysfunction	NOUN
bptjm-67	37	92	and	and	CCONJ
bptjm-67	37	93	development	development	NOUN
bptjm-67	37	94	of	of	ADP
bptjm-67	37	95	key	key	ADJ
bptjm-67	37	96	features	feature	NOUN
bptjm-67	37	97	of	of	ADP
bptjm-67	37	98	cognitive	cognitive	ADJ
bptjm-67	37	99	disorders	disorder	NOUN
bptjm-67	37	100	.	.	PUNCT
bptjm-67	38	1	2.1	2.1	NUM
bptjm-67	38	2	associated	associate	VERB
bptjm-67	38	3	biomarkers	biomarker	NOUN
bptjm-67	38	4	2.1.1	2.1.1	NUM
bptjm-67	38	5	pericyte	pericyte	NOUN
bptjm-67	38	6	detachment	detachment	NOUN
bptjm-67	38	7	pericytes	pericyte	NOUN
bptjm-67	38	8	are	be	AUX
bptjm-67	38	9	instrumental	instrumental	ADJ
bptjm-67	38	10	in	in	ADP
bptjm-67	38	11	maintaining	maintain	VERB
bptjm-67	38	12	the	the	DET
bptjm-67	38	13	nvu	nvu	NOUN
bptjm-67	38	14	,	,	PUNCT
bptjm-67	38	15	as	as	SCONJ
bptjm-67	38	16	they	they	PRON
bptjm-67	38	17	are	be	AUX
bptjm-67	38	18	positioned	position	VERB
bptjm-67	38	19	in	in	ADP
bptjm-67	38	20	the	the	DET
bptjm-67	38	21	unit	unit	NOUN
bptjm-67	38	22	between	between	ADP
bptjm-67	38	23	endothelial	endothelial	ADJ
bptjm-67	38	24	cells	cell	NOUN
bptjm-67	38	25	,	,	PUNCT
bptjm-67	38	26	astrocytes	astrocyte	NOUN
bptjm-67	38	27	,	,	PUNCT
bptjm-67	38	28	and	and	CCONJ
bptjm-67	38	29	neurons	neuron	NOUN
bptjm-67	38	30	.	.	PUNCT
bptjm-67	39	1	they	they	PRON
bptjm-67	39	2	contribute	contribute	VERB
bptjm-67	39	3	not	not	PART
bptjm-67	39	4	only	only	ADV
bptjm-67	39	5	to	to	ADP
bptjm-67	39	6	the	the	DET
bptjm-67	39	7	structural	structural	ADJ
bptjm-67	39	8	maintenance	maintenance	NOUN
bptjm-67	39	9	of	of	ADP
bptjm-67	39	10	blood	blood	NOUN
bptjm-67	39	11	vessels	vessel	NOUN
bptjm-67	39	12	but	but	CCONJ
bptjm-67	39	13	also	also	ADV
bptjm-67	39	14	to	to	ADP
bptjm-67	39	15	the	the	DET
bptjm-67	39	16	regulation	regulation	NOUN
bptjm-67	39	17	of	of	ADP
bptjm-67	39	18	molecular	molecular	ADJ
bptjm-67	39	19	waste	waste	NOUN
bptjm-67	39	20	clearance	clearance	NOUN
bptjm-67	39	21	,	,	PUNCT
bptjm-67	39	22	cell	cell	NOUN
bptjm-67	39	23	signaling	signaling	ADJ
bptjm-67	39	24	,	,	PUNCT
bptjm-67	39	25	and	and	CCONJ
bptjm-67	39	26	cerebral	cerebral	ADJ
bptjm-67	39	27	blood	blood	NOUN
bptjm-67	39	28	flow	flow	NOUN
bptjm-67	39	29	.	.	PUNCT
bptjm-67	40	1	for	for	ADP
bptjm-67	40	2	example	example	NOUN
bptjm-67	40	3	,	,	PUNCT
bptjm-67	40	4	pericytes	pericyte	NOUN
bptjm-67	40	5	influence	influence	VERB
bptjm-67	40	6	the	the	DET
bptjm-67	40	7	activity	activity	NOUN
bptjm-67	40	8	of	of	ADP
bptjm-67	40	9	proteins	protein	NOUN
bptjm-67	40	10	that	that	PRON
bptjm-67	40	11	preserve	preserve	VERB
bptjm-67	40	12	the	the	DET
bptjm-67	40	13	tight	tight	ADJ
bptjm-67	40	14	junctions	junction	NOUN
bptjm-67	40	15	of	of	ADP
bptjm-67	40	16	the	the	DET
bptjm-67	40	17	blood	blood	NOUN
bptjm-67	40	18	–	–	PUNCT
bptjm-67	40	19	brain	brain	NOUN
bptjm-67	40	20	barrier	barrier	NOUN
bptjm-67	40	21	(	(	PUNCT
bptjm-67	40	22	bbb	bbb	NOUN
bptjm-67	40	23	)	)	PUNCT
bptjm-67	40	24	and	and	CCONJ
bptjm-67	40	25	modulate	modulate	VERB
bptjm-67	40	26	the	the	DET
bptjm-67	40	27	transport	transport	NOUN
bptjm-67	40	28	of	of	ADP
bptjm-67	40	29	fluid	fluid	NOUN
bptjm-67	40	30	-	-	PUNCT
bptjm-67	40	31	filled	fill	VERB
bptjm-67	40	32	vesicles	vesicle	NOUN
bptjm-67	40	33	across	across	ADP
bptjm-67	40	34	it.12	it.12	PROPN
bptjm-67	40	35	in	in	ADP
bptjm-67	40	36	the	the	DET
bptjm-67	40	37	cases	case	NOUN
bptjm-67	40	38	of	of	ADP
bptjm-67	40	39	higher	high	ADJ
bptjm-67	40	40	blood	blood	NOUN
bptjm-67	40	41	pressure	pressure	NOUN
bptjm-67	40	42	,	,	PUNCT
bptjm-67	40	43	which	which	PRON
bptjm-67	40	44	can	can	AUX
bptjm-67	40	45	stretch	stretch	VERB
bptjm-67	40	46	the	the	DET
bptjm-67	40	47	vein	vein	NOUN
bptjm-67	40	48	and	and	CCONJ
bptjm-67	40	49	weaken	weaken	VERB
bptjm-67	40	50	it	it	PRON
bptjm-67	40	51	,	,	PUNCT
bptjm-67	40	52	pericyte	pericyte	NOUN
bptjm-67	40	53	detachment	detachment	NOUN
bptjm-67	40	54	from	from	ADP
bptjm-67	40	55	the	the	DET
bptjm-67	40	56	unit	unit	NOUN
bptjm-67	40	57	is	be	AUX
bptjm-67	40	58	promoted	promote	VERB
bptjm-67	40	59	.	.	PUNCT
bptjm-67	41	1	pericyte	pericyte	NOUN
bptjm-67	41	2	detachment	detachment	NOUN
bptjm-67	41	3	from	from	ADP
bptjm-67	41	4	around	around	ADP
bptjm-67	41	5	the	the	DET
bptjm-67	41	6	circumference	circumference	NOUN
bptjm-67	41	7	of	of	ADP
bptjm-67	41	8	the	the	DET
bptjm-67	41	9	vein	vein	NOUN
bptjm-67	41	10	can	can	AUX
bptjm-67	41	11	lead	lead	VERB
bptjm-67	41	12	to	to	ADP
bptjm-67	41	13	bbb	bbb	PROPN
bptjm-67	41	14	permeability	permeability	NOUN
bptjm-67	41	15	,	,	PUNCT
bptjm-67	41	16	neuroinflammation	neuroinflammation	NOUN
bptjm-67	41	17	,	,	PUNCT
bptjm-67	41	18	and	and	CCONJ
bptjm-67	41	19	issues	issue	NOUN
bptjm-67	41	20	with	with	ADP
bptjm-67	41	21	neuronal	neuronal	ADJ
bptjm-67	41	22	communication	communication	NOUN
bptjm-67	41	23	,	,	PUNCT
bptjm-67	41	24	ultimately	ultimately	ADV
bptjm-67	41	25	resulting	result	VERB
bptjm-67	41	26	in	in	ADP
bptjm-67	41	27	cognitive	cognitive	ADJ
bptjm-67	41	28	dysfunction	dysfunction	NOUN
bptjm-67	41	29	.	.	PUNCT
bptjm-67	42	1	additionally	additionally	ADV
bptjm-67	42	2	,	,	PUNCT
bptjm-67	42	3	recent	recent	ADJ
bptjm-67	42	4	studies	study	NOUN
bptjm-67	42	5	have	have	AUX
bptjm-67	42	6	implicated	implicate	VERB
bptjm-67	42	7	pericyte	pericyte	NOUN
bptjm-67	42	8	detachment	detachment	NOUN
bptjm-67	42	9	with	with	ADP
bptjm-67	42	10	hypoxia	hypoxia	NOUN
bptjm-67	42	11	and	and	CCONJ
bptjm-67	42	12	loss	loss	NOUN
bptjm-67	42	13	of	of	ADP
bptjm-67	42	14	myelination	myelination	NOUN
bptjm-67	42	15	,	,	PUNCT
bptjm-67	42	16	which	which	PRON
bptjm-67	42	17	leads	lead	VERB
bptjm-67	42	18	to	to	ADP
bptjm-67	42	19	the	the	DET
bptjm-67	42	20	loss	loss	NOUN
bptjm-67	42	21	of	of	ADP
bptjm-67	42	22	essential	essential	ADJ
bptjm-67	42	23	connections	connection	NOUN
bptjm-67	42	24	within	within	ADP
bptjm-67	42	25	the	the	DET
bptjm-67	42	26	brain.13	brain.13	PROPN
bptjm-67	42	27	2.1.2	2.1.2	NUM
bptjm-67	42	28	genetic	genetic	ADJ
bptjm-67	42	29	factors	factor	NOUN
bptjm-67	42	30	the	the	DET
bptjm-67	42	31	apoeε4	apoeε4	PROPN
bptjm-67	42	32	allele	allele	PROPN
bptjm-67	42	33	,	,	PUNCT
bptjm-67	42	34	located	locate	VERB
bptjm-67	42	35	on	on	ADP
bptjm-67	42	36	chromosome	chromosome	NOUN
bptjm-67	42	37	19	19	NUM
bptjm-67	42	38	,	,	PUNCT
bptjm-67	42	39	has	have	AUX
bptjm-67	42	40	often	often	ADV
bptjm-67	42	41	been	be	AUX
bptjm-67	42	42	described	describe	VERB
bptjm-67	42	43	as	as	ADP
bptjm-67	42	44	the	the	DET
bptjm-67	42	45	greatest	great	ADJ
bptjm-67	42	46	genetic	genetic	ADJ
bptjm-67	42	47	risk	risk	NOUN
bptjm-67	42	48	factor	factor	NOUN
bptjm-67	42	49	for	for	ADP
bptjm-67	42	50	alzheimer	alzheimer	PROPN
bptjm-67	42	51	’s	’s	PART
bptjm-67	42	52	.	.	PUNCT
bptjm-67	43	1	although	although	SCONJ
bptjm-67	43	2	its	its	PRON
bptjm-67	43	3	exact	exact	ADJ
bptjm-67	43	4	role	role	NOUN
bptjm-67	43	5	in	in	ADP
bptjm-67	43	6	disease	disease	NOUN
bptjm-67	43	7	pathology	pathology	NOUN
bptjm-67	43	8	remains	remains	AUX
bptjm-67	43	9	incompletely	incompletely	ADV
bptjm-67	43	10	understood	understand	VERB
bptjm-67	43	11	,	,	PUNCT
bptjm-67	43	12	it	it	PRON
bptjm-67	43	13	is	be	AUX
bptjm-67	43	14	known	know	VERB
bptjm-67	43	15	to	to	PART
bptjm-67	43	16	be	be	AUX
bptjm-67	43	17	involved	involve	VERB
bptjm-67	43	18	in	in	ADP
bptjm-67	43	19	lipid	lipid	NOUN
bptjm-67	43	20	transport	transport	NOUN
bptjm-67	43	21	within	within	ADP
bptjm-67	43	22	the	the	DET
bptjm-67	43	23	brain	brain	NOUN
bptjm-67	43	24	and	and	CCONJ
bptjm-67	43	25	the	the	DET
bptjm-67	43	26	production	production	NOUN
bptjm-67	43	27	of	of	ADP
bptjm-67	43	28	β	β	NOUN
bptjm-67	43	29	-	-	NOUN
bptjm-67	43	30	amyloid	amyloid	NOUN
bptjm-67	43	31	and	and	CCONJ
bptjm-67	43	32	tau	tau	PROPN
bptjm-67	43	33	proteins	protein	NOUN
bptjm-67	43	34	—	—	PUNCT
bptjm-67	43	35	key	key	ADJ
bptjm-67	43	36	biomarkers	biomarker	NOUN
bptjm-67	43	37	of	of	ADP
bptjm-67	43	38	alzheimer	alzheimer	PROPN
bptjm-67	43	39	’s	’s	PART
bptjm-67	43	40	disease	disease	NOUN
bptjm-67	43	41	.	.	PUNCT
bptjm-67	44	1	emerging	emerge	VERB
bptjm-67	44	2	research	research	NOUN
bptjm-67	44	3	suggests	suggest	VERB
bptjm-67	44	4	that	that	SCONJ
bptjm-67	44	5	apoeε4	apoeε4	PROPN
bptjm-67	44	6	also	also	ADV
bptjm-67	44	7	disrupts	disrupt	VERB
bptjm-67	44	8	neurovascular	neurovascular	ADJ
bptjm-67	44	9	regulation	regulation	NOUN
bptjm-67	44	10	and	and	CCONJ
bptjm-67	44	11	exacerbates	exacerbate	VERB
bptjm-67	44	12	cognitive	cognitive	ADJ
bptjm-67	44	13	decline	decline	NOUN
bptjm-67	44	14	.	.	PUNCT
bptjm-67	45	1	individuals	individual	NOUN
bptjm-67	45	2	carrying	carry	VERB
bptjm-67	45	3	this	this	DET
bptjm-67	45	4	allele	allele	NOUN
bptjm-67	45	5	exhibit	exhibit	NOUN
bptjm-67	45	6	marked	mark	VERB
bptjm-67	45	7	pericyte	pericyte	NOUN
bptjm-67	45	8	deficiency	deficiency	NOUN
bptjm-67	45	9	—	—	PUNCT
bptjm-67	45	10	approximately	approximately	ADV
bptjm-67	45	11	50	50	NUM
bptjm-67	45	12	%	%	NOUN
bptjm-67	45	13	fewer	few	ADJ
bptjm-67	45	14	pericytes	pericyte	NOUN
bptjm-67	45	15	compared	compare	VERB
bptjm-67	45	16	to	to	ADP
bptjm-67	45	17	individuals	individual	NOUN
bptjm-67	45	18	without	without	ADP
bptjm-67	45	19	the	the	DET
bptjm-67	45	20	allele	allele	NOUN
bptjm-67	45	21	—	—	PUNCT
bptjm-67	45	22	and	and	CCONJ
bptjm-67	45	23	increased	increase	VERB
bptjm-67	45	24	blood	blood	NOUN
bptjm-67	45	25	–	–	PUNCT
bptjm-67	45	26	brain	brain	NOUN
bptjm-67	45	27	barrier	barrier	NOUN
bptjm-67	45	28	breakdown.14	breakdown.14	VERB
bptjm-67	45	29	the	the	DET
bptjm-67	45	30	correlation	correlation	NOUN
bptjm-67	45	31	between	between	ADP
bptjm-67	45	32	apoeε4	apoeε4	PROPN
bptjm-67	45	33	with	with	ADP
bptjm-67	45	34	protein	protein	NOUN
bptjm-67	45	35	berkeley	berkeley	PROPN
bptjm-67	45	36	pharma	pharma	PROPN
bptjm-67	45	37	tech	tech	NOUN
bptjm-67	45	38	journal	journal	NOUN
bptjm-67	45	39	of	of	ADP
bptjm-67	45	40	medicine	medicine	NOUN
bptjm-67	45	41	|	|	ADV
bptjm-67	45	42	127	127	NUM
bptjm-67	45	43	aggregate	aggregate	ADJ
bptjm-67	45	44	formation	formation	NOUN
bptjm-67	45	45	and	and	CCONJ
bptjm-67	45	46	nvc	nvc	NOUN
bptjm-67	45	47	regulation	regulation	NOUN
bptjm-67	45	48	supports	support	VERB
bptjm-67	45	49	our	our	PRON
bptjm-67	45	50	hypothesis	hypothesis	NOUN
bptjm-67	45	51	that	that	SCONJ
bptjm-67	45	52	the	the	DET
bptjm-67	45	53	nvc	nvc	NOUN
bptjm-67	45	54	contributes	contribute	VERB
bptjm-67	45	55	to	to	PART
bptjm-67	45	56	cognitive	cognitive	VERB
bptjm-67	45	57	decline.15	decline.15	NOUN
bptjm-67	45	58	2.1.3	2.1.3	NUM
bptjm-67	45	59	vascular	vascular	ADJ
bptjm-67	45	60	dysfunction	dysfunction	NOUN
bptjm-67	45	61	given	give	VERB
bptjm-67	45	62	the	the	DET
bptjm-67	45	63	nvu	nvu	NOUN
bptjm-67	45	64	’s	’s	PART
bptjm-67	45	65	intimate	intimate	ADJ
bptjm-67	45	66	relationship	relationship	NOUN
bptjm-67	45	67	with	with	ADP
bptjm-67	45	68	brain	brain	NOUN
bptjm-67	45	69	function	function	NOUN
bptjm-67	45	70	,	,	PUNCT
bptjm-67	45	71	vascular	vascular	ADJ
bptjm-67	45	72	dysfunction	dysfunction	NOUN
bptjm-67	45	73	as	as	ADP
bptjm-67	45	74	a	a	DET
bptjm-67	45	75	whole	whole	NOUN
bptjm-67	45	76	can	can	AUX
bptjm-67	45	77	act	act	VERB
bptjm-67	45	78	as	as	ADP
bptjm-67	45	79	a	a	DET
bptjm-67	45	80	root	root	NOUN
bptjm-67	45	81	for	for	ADP
bptjm-67	45	82	brain	brain	NOUN
bptjm-67	45	83	dysfunction	dysfunction	NOUN
bptjm-67	45	84	.	.	PUNCT
bptjm-67	46	1	the	the	DET
bptjm-67	46	2	“	"	PUNCT
bptjm-67	46	3	2	2	NUM
bptjm-67	46	4	-	-	PUNCT
bptjm-67	46	5	hit	hit	VERB
bptjm-67	46	6	vascular	vascular	ADJ
bptjm-67	46	7	hypothesis	hypothesis	NOUN
bptjm-67	46	8	model	model	NOUN
bptjm-67	46	9	”	"	PUNCT
bptjm-67	46	10	,	,	PUNCT
bptjm-67	46	11	proposed	propose	VERB
bptjm-67	46	12	by	by	ADP
bptjm-67	46	13	berislav	berislav	NOUN
bptjm-67	46	14	v.	v.	ADP
bptjm-67	46	15	zlokovic	zlokovic	NUM
bptjm-67	46	16	,	,	PUNCT
bptjm-67	46	17	implicates	implicate	VERB
bptjm-67	46	18	vascular	vascular	ADJ
bptjm-67	46	19	dysfunction	dysfunction	NOUN
bptjm-67	46	20	in	in	ADP
bptjm-67	46	21	exacerbating	exacerbate	VERB
bptjm-67	46	22	cognitive	cognitive	ADJ
bptjm-67	46	23	decline.16	decline.16	NOUN
bptjm-67	46	24	the	the	DET
bptjm-67	46	25	“	"	PUNCT
bptjm-67	46	26	first	first	ADJ
bptjm-67	46	27	hit	hit	NOUN
bptjm-67	46	28	”	"	PUNCT
bptjm-67	46	29	are	be	AUX
bptjm-67	46	30	risk	risk	NOUN
bptjm-67	46	31	factors	factor	NOUN
bptjm-67	46	32	such	such	ADJ
bptjm-67	46	33	as	as	ADP
bptjm-67	46	34	aging	age	VERB
bptjm-67	46	35	,	,	PUNCT
bptjm-67	46	36	atherosclerosis	atherosclerosis	NOUN
bptjm-67	46	37	,	,	PUNCT
bptjm-67	46	38	hypertension	hypertension	NOUN
bptjm-67	46	39	,	,	PUNCT
bptjm-67	46	40	diabetes	diabetes	NOUN
bptjm-67	46	41	,	,	PUNCT
bptjm-67	46	42	or	or	CCONJ
bptjm-67	46	43	stroke	stroke	NOUN
bptjm-67	46	44	,	,	PUNCT
bptjm-67	46	45	all	all	PRON
bptjm-67	46	46	of	of	ADP
bptjm-67	46	47	which	which	PRON
bptjm-67	46	48	jeopardize	jeopardize	VERB
bptjm-67	46	49	or	or	CCONJ
bptjm-67	46	50	breakdown	breakdown	VERB
bptjm-67	46	51	vascular	vascular	ADJ
bptjm-67	46	52	integrity	integrity	NOUN
bptjm-67	46	53	and	and	CCONJ
bptjm-67	46	54	alter	alter	VERB
bptjm-67	46	55	cerebral	cerebral	ADJ
bptjm-67	46	56	blood	blood	NOUN
bptjm-67	46	57	flow	flow	NOUN
bptjm-67	46	58	.	.	PUNCT
bptjm-67	47	1	the	the	DET
bptjm-67	47	2	“	"	PUNCT
bptjm-67	47	3	second	second	ADJ
bptjm-67	47	4	hit	hit	NOUN
bptjm-67	47	5	”	"	PUNCT
bptjm-67	47	6	refers	refer	VERB
bptjm-67	47	7	to	to	ADP
bptjm-67	47	8	the	the	DET
bptjm-67	47	9	increased	increase	VERB
bptjm-67	47	10	aβ	aβ	NOUN
bptjm-67	47	11	protein	protein	NOUN
bptjm-67	47	12	levels	level	NOUN
bptjm-67	47	13	,	,	PUNCT
bptjm-67	47	14	inflammation	inflammation	NOUN
bptjm-67	47	15	,	,	PUNCT
bptjm-67	47	16	and	and	CCONJ
bptjm-67	47	17	tau	tau	PROPN
bptjm-67	47	18	protein	protein	NOUN
bptjm-67	47	19	levels	level	NOUN
bptjm-67	47	20	that	that	PRON
bptjm-67	47	21	result	result	VERB
bptjm-67	47	22	,	,	PUNCT
bptjm-67	47	23	which	which	PRON
bptjm-67	47	24	causes	cause	VERB
bptjm-67	47	25	even	even	ADV
bptjm-67	47	26	further	further	ADJ
bptjm-67	47	27	decline	decline	NOUN
bptjm-67	47	28	.	.	PUNCT
bptjm-67	48	1	this	this	DET
bptjm-67	48	2	model	model	NOUN
bptjm-67	48	3	describes	describe	VERB
bptjm-67	48	4	a	a	DET
bptjm-67	48	5	positive	positive	ADJ
bptjm-67	48	6	feedback	feedback	NOUN
bptjm-67	48	7	loop	loop	NOUN
bptjm-67	48	8	between	between	ADP
bptjm-67	48	9	vascular	vascular	NOUN
bptjm-67	48	10	and	and	CCONJ
bptjm-67	48	11	brain	brain	NOUN
bptjm-67	48	12	dysfunction	dysfunction	NOUN
bptjm-67	48	13	:	:	PUNCT
bptjm-67	48	14	injury	injury	NOUN
bptjm-67	48	15	to	to	ADP
bptjm-67	48	16	the	the	DET
bptjm-67	48	17	vascular	vascular	ADJ
bptjm-67	48	18	system	system	NOUN
bptjm-67	48	19	can	can	AUX
bptjm-67	48	20	accelerate	accelerate	VERB
bptjm-67	48	21	neurodegeneration	neurodegeneration	NOUN
bptjm-67	48	22	,	,	PUNCT
bptjm-67	48	23	while	while	SCONJ
bptjm-67	48	24	neuronal	neuronal	ADJ
bptjm-67	48	25	damage	damage	NOUN
bptjm-67	48	26	can	can	AUX
bptjm-67	48	27	,	,	PUNCT
bptjm-67	48	28	in	in	ADP
bptjm-67	48	29	turn	turn	NOUN
bptjm-67	48	30	,	,	PUNCT
bptjm-67	48	31	worsen	worsen	VERB
bptjm-67	48	32	vascular	vascular	ADJ
bptjm-67	48	33	health.17	health.17	NOUN
bptjm-67	48	34	consequently	consequently	ADV
bptjm-67	48	35	,	,	PUNCT
bptjm-67	48	36	vascular	vascular	ADJ
bptjm-67	48	37	markers	marker	NOUN
bptjm-67	48	38	may	may	AUX
bptjm-67	48	39	serve	serve	VERB
bptjm-67	48	40	as	as	ADP
bptjm-67	48	41	valuable	valuable	ADJ
bptjm-67	48	42	early	early	ADJ
bptjm-67	48	43	indicators	indicator	NOUN
bptjm-67	48	44	for	for	ADP
bptjm-67	48	45	the	the	DET
bptjm-67	48	46	prevention	prevention	NOUN
bptjm-67	48	47	and	and	CCONJ
bptjm-67	48	48	early	early	ADJ
bptjm-67	48	49	-	-	PUNCT
bptjm-67	48	50	stage	stage	NOUN
bptjm-67	48	51	intervention	intervention	NOUN
bptjm-67	48	52	of	of	ADP
bptjm-67	48	53	neurodegenerative	neurodegenerative	ADJ
bptjm-67	48	54	diseases	disease	NOUN
bptjm-67	48	55	.	.	PUNCT
bptjm-67	49	1	berkeley	berkeley	PROPN
bptjm-67	49	2	pharma	pharma	PROPN
bptjm-67	49	3	tech	tech	PROPN
bptjm-67	49	4	journal	journal	NOUN
bptjm-67	49	5	of	of	ADP
bptjm-67	49	6	medicine	medicine	NOUN
bptjm-67	49	7	|	|	ADV
bptjm-67	49	8	128	128	NUM
bptjm-67	49	9	figure	figure	NOUN
bptjm-67	49	10	5	5	NUM
bptjm-67	49	11	:	:	SYM
bptjm-67	49	12	2	2	NUM
bptjm-67	49	13	-	-	PUNCT
bptjm-67	49	14	hit	hit	VERB
bptjm-67	49	15	hypothesis	hypothesis	NOUN
bptjm-67	49	16	.	.	PUNCT
bptjm-67	50	1	2	2	NUM
bptjm-67	50	2	-	-	PUNCT
bptjm-67	50	3	hit	hit	VERB
bptjm-67	50	4	hypothesis	hypothesis	NOUN
bptjm-67	50	5	model	model	NOUN
bptjm-67	50	6	shows	show	VERB
bptjm-67	50	7	that	that	SCONJ
bptjm-67	50	8	vascular	vascular	ADJ
bptjm-67	50	9	factors	factor	NOUN
bptjm-67	50	10	and	and	CCONJ
bptjm-67	50	11	genetic	genetic	ADJ
bptjm-67	50	12	factors	factor	NOUN
bptjm-67	50	13	discussed	discuss	VERB
bptjm-67	50	14	before	before	ADP
bptjm-67	50	15	serve	serve	NOUN
bptjm-67	50	16	as	as	ADP
bptjm-67	50	17	predisposing	predispose	VERB
bptjm-67	50	18	factors	factor	NOUN
bptjm-67	50	19	to	to	PART
bptjm-67	50	20	‘	'	PUNCT
bptjm-67	50	21	hit	hit	VERB
bptjm-67	50	22	1	1	NUM
bptjm-67	50	23	vascular	vascular	ADJ
bptjm-67	50	24	damage	damage	NOUN
bptjm-67	50	25	,	,	PUNCT
bptjm-67	50	26	’	'	PUNCT
bptjm-67	50	27	which	which	PRON
bptjm-67	50	28	causes	cause	VERB
bptjm-67	50	29	bbb	bbb	NOUN
bptjm-67	50	30	breakdown	breakdown	NOUN
bptjm-67	50	31	and	and	CCONJ
bptjm-67	50	32	‘	'	PUNCT
bptjm-67	50	33	hit	hit	VERB
bptjm-67	50	34	2	2	NUM
bptjm-67	50	35	’	'	PUNCT
bptjm-67	50	36	:	:	PUNCT
bptjm-67	50	37	physiological	physiological	ADJ
bptjm-67	50	38	manifestations	manifestation	NOUN
bptjm-67	50	39	of	of	ADP
bptjm-67	50	40	cognitive	cognitive	ADJ
bptjm-67	50	41	decline	decline	NOUN
bptjm-67	50	42	such	such	ADJ
bptjm-67	50	43	as	as	ADP
bptjm-67	50	44	protein	protein	NOUN
bptjm-67	50	45	aggregation	aggregation	NOUN
bptjm-67	50	46	and	and	CCONJ
bptjm-67	50	47	inflammation	inflammation	NOUN
bptjm-67	50	48	.	.	PUNCT
bptjm-67	51	1	these	these	DET
bptjm-67	51	2	hits	hit	NOUN
bptjm-67	51	3	cause	cause	VERB
bptjm-67	51	4	significant	significant	ADJ
bptjm-67	51	5	neurodegeneration	neurodegeneration	NOUN
bptjm-67	51	6	and	and	CCONJ
bptjm-67	51	7	also	also	ADV
bptjm-67	51	8	(	(	PUNCT
bptjm-67	51	9	not	not	PART
bptjm-67	51	10	pictured	picture	VERB
bptjm-67	51	11	)	)	PUNCT
bptjm-67	51	12	a	a	DET
bptjm-67	51	13	positive	positive	ADJ
bptjm-67	51	14	feedback	feedback	NOUN
bptjm-67	51	15	loop	loop	NOUN
bptjm-67	51	16	of	of	ADP
bptjm-67	51	17	brain	brain	NOUN
bptjm-67	51	18	and	and	CCONJ
bptjm-67	51	19	vascular	vascular	ADJ
bptjm-67	51	20	damage	damage	NOUN
bptjm-67	51	21	.	.	PUNCT
bptjm-67	52	1	2.1.4	2.1.4	NUM
bptjm-67	52	2	blood	blood	NOUN
bptjm-67	52	3	-	-	PUNCT
bptjm-67	52	4	brain	brain	NOUN
bptjm-67	52	5	barrier	barrier	NOUN
bptjm-67	52	6	breakdown	breakdown	VERB
bptjm-67	52	7	the	the	DET
bptjm-67	52	8	blood	blood	NOUN
bptjm-67	52	9	-	-	PUNCT
bptjm-67	52	10	brain	brain	NOUN
bptjm-67	52	11	barrier	barrier	NOUN
bptjm-67	52	12	(	(	PUNCT
bptjm-67	52	13	bbb	bbb	NOUN
bptjm-67	52	14	)	)	PUNCT
bptjm-67	52	15	regulates	regulate	VERB
bptjm-67	52	16	the	the	DET
bptjm-67	52	17	exchange	exchange	NOUN
bptjm-67	52	18	of	of	ADP
bptjm-67	52	19	compounds	compound	NOUN
bptjm-67	52	20	between	between	ADP
bptjm-67	52	21	the	the	DET
bptjm-67	52	22	blood	blood	NOUN
bptjm-67	52	23	and	and	CCONJ
bptjm-67	52	24	the	the	DET
bptjm-67	52	25	brain	brain	NOUN
bptjm-67	52	26	by	by	ADP
bptjm-67	52	27	selectively	selectively	ADV
bptjm-67	52	28	transporting	transport	VERB
bptjm-67	52	29	solutes	solute	NOUN
bptjm-67	52	30	through	through	ADP
bptjm-67	52	31	active	active	ADJ
bptjm-67	52	32	transport	transport	NOUN
bptjm-67	52	33	mechanisms	mechanism	NOUN
bptjm-67	52	34	and	and	CCONJ
bptjm-67	52	35	passive	passive	ADJ
bptjm-67	52	36	diffusion	diffusion	NOUN
bptjm-67	52	37	.	.	PUNCT
bptjm-67	53	1	these	these	PRON
bptjm-67	53	2	include	include	VERB
bptjm-67	53	3	organic	organic	ADJ
bptjm-67	53	4	compounds	compound	NOUN
bptjm-67	53	5	such	such	ADJ
bptjm-67	53	6	as	as	ADP
bptjm-67	53	7	vitamins	vitamin	NOUN
bptjm-67	53	8	,	,	PUNCT
bptjm-67	53	9	hormones	hormone	NOUN
bptjm-67	53	10	,	,	PUNCT
bptjm-67	53	11	and	and	CCONJ
bptjm-67	53	12	macromolecules	macromolecule	NOUN
bptjm-67	53	13	necessary	necessary	ADJ
bptjm-67	53	14	for	for	ADP
bptjm-67	53	15	brain	brain	NOUN
bptjm-67	53	16	neuron	neuron	NOUN
bptjm-67	53	17	functions	function	NOUN
bptjm-67	53	18	.	.	PUNCT
bptjm-67	54	1	different	different	ADJ
bptjm-67	54	2	levels	level	NOUN
bptjm-67	54	3	of	of	ADP
bptjm-67	54	4	stress	stress	NOUN
bptjm-67	54	5	such	such	ADJ
bptjm-67	54	6	as	as	ADP
bptjm-67	54	7	hypertension	hypertension	NOUN
bptjm-67	54	8	or	or	CCONJ
bptjm-67	54	9	vascular	vascular	ADJ
bptjm-67	54	10	recanalization	recanalization	NOUN
bptjm-67	54	11	can	can	AUX
bptjm-67	54	12	cause	cause	VERB
bptjm-67	54	13	the	the	DET
bptjm-67	54	14	breakdown	breakdown	NOUN
bptjm-67	54	15	of	of	ADP
bptjm-67	54	16	the	the	DET
bptjm-67	54	17	barrier	barrier	NOUN
bptjm-67	54	18	.	.	PUNCT
bptjm-67	55	1	not	not	PART
bptjm-67	55	2	only	only	ADV
bptjm-67	55	3	does	do	VERB
bptjm-67	55	4	the	the	DET
bptjm-67	55	5	breakdown	breakdown	NOUN
bptjm-67	55	6	of	of	ADP
bptjm-67	55	7	the	the	DET
bptjm-67	55	8	barrier	barrier	NOUN
bptjm-67	55	9	result	result	NOUN
bptjm-67	55	10	in	in	ADP
bptjm-67	55	11	the	the	DET
bptjm-67	55	12	loss	loss	NOUN
bptjm-67	55	13	of	of	ADP
bptjm-67	55	14	its	its	PRON
bptjm-67	55	15	functions	function	NOUN
bptjm-67	55	16	,	,	PUNCT
bptjm-67	55	17	but	but	CCONJ
bptjm-67	55	18	it	it	PRON
bptjm-67	55	19	also	also	ADV
bptjm-67	55	20	allows	allow	VERB
bptjm-67	55	21	for	for	ADP
bptjm-67	55	22	the	the	DET
bptjm-67	55	23	release	release	NOUN
bptjm-67	55	24	of	of	ADP
bptjm-67	55	25	neurodegenerative	neurodegenerative	ADJ
bptjm-67	55	26	compounds	compound	NOUN
bptjm-67	55	27	such	such	ADJ
bptjm-67	55	28	as	as	ADP
bptjm-67	55	29	protein	protein	NOUN
bptjm-67	55	30	aggregates	aggregate	NOUN
bptjm-67	55	31	and	and	CCONJ
bptjm-67	55	32	pathogens	pathogen	NOUN
bptjm-67	55	33	that	that	PRON
bptjm-67	55	34	are	be	AUX
bptjm-67	55	35	absorbed	absorb	VERB
bptjm-67	55	36	by	by	ADP
bptjm-67	55	37	the	the	DET
bptjm-67	55	38	blood	blood	NOUN
bptjm-67	55	39	to	to	ADP
bptjm-67	55	40	the	the	DET
bptjm-67	55	41	brain	brain	NOUN
bptjm-67	55	42	which	which	PRON
bptjm-67	55	43	leads	lead	VERB
bptjm-67	55	44	to	to	ADP
bptjm-67	55	45	neurovascular	neurovascular	ADJ
bptjm-67	55	46	coupling	coupling	NOUN
bptjm-67	55	47	-	-	PUNCT
bptjm-67	55	48	related	relate	VERB
bptjm-67	55	49	diseases	disease	NOUN
bptjm-67	55	50	.	.	PUNCT
bptjm-67	56	1	bbb	bbb	NOUN
bptjm-67	56	2	breakdown	breakdown	NOUN
bptjm-67	56	3	is	be	AUX
bptjm-67	56	4	also	also	ADV
bptjm-67	56	5	associated	associate	VERB
bptjm-67	56	6	with	with	ADP
bptjm-67	56	7	aging	age	VERB
bptjm-67	56	8	,	,	PUNCT
bptjm-67	56	9	berkeley	berkeley	PROPN
bptjm-67	56	10	pharma	pharma	PROPN
bptjm-67	56	11	tech	tech	NOUN
bptjm-67	56	12	journal	journal	NOUN
bptjm-67	56	13	of	of	ADP
bptjm-67	56	14	medicine	medicine	NOUN
bptjm-67	56	15	|	|	ADV
bptjm-67	56	16	129	129	NUM
bptjm-67	56	17	which	which	PRON
bptjm-67	56	18	progressively	progressively	ADV
bptjm-67	56	19	alters	alter	VERB
bptjm-67	56	20	its	its	PRON
bptjm-67	56	21	permeability	permeability	NOUN
bptjm-67	56	22	.	.	PUNCT
bptjm-67	57	1	given	give	VERB
bptjm-67	57	2	the	the	DET
bptjm-67	57	3	bbb	bbb	PROPN
bptjm-67	57	4	’s	’s	PART
bptjm-67	57	5	close	close	ADJ
bptjm-67	57	6	functional	functional	ADJ
bptjm-67	57	7	relationship	relationship	NOUN
bptjm-67	57	8	with	with	ADP
bptjm-67	57	9	pericytes	pericyte	NOUN
bptjm-67	57	10	,	,	PUNCT
bptjm-67	57	11	astrocytes	astrocyte	NOUN
bptjm-67	57	12	,	,	PUNCT
bptjm-67	57	13	and	and	CCONJ
bptjm-67	57	14	neurons	neuron	NOUN
bptjm-67	57	15	,	,	PUNCT
bptjm-67	57	16	its	its	PRON
bptjm-67	57	17	failure	failure	NOUN
bptjm-67	57	18	is	be	AUX
bptjm-67	57	19	often	often	ADV
bptjm-67	57	20	accompanied	accompany	VERB
bptjm-67	57	21	by	by	ADP
bptjm-67	57	22	dysfunction	dysfunction	NOUN
bptjm-67	57	23	in	in	ADP
bptjm-67	57	24	these	these	DET
bptjm-67	57	25	associated	associated	ADJ
bptjm-67	57	26	cells	cell	NOUN
bptjm-67	57	27	—	—	PUNCT
bptjm-67	57	28	providing	provide	VERB
bptjm-67	57	29	a	a	DET
bptjm-67	57	30	broader	broad	ADJ
bptjm-67	57	31	pathological	pathological	ADJ
bptjm-67	57	32	context	context	NOUN
bptjm-67	57	33	for	for	ADP
bptjm-67	57	34	detection	detection	NOUN
bptjm-67	57	35	and	and	CCONJ
bptjm-67	57	36	diagnosis	diagnosis	NOUN
bptjm-67	57	37	.	.	PUNCT
bptjm-67	58	1	3	3	X
bptjm-67	58	2	.	.	X
bptjm-67	58	3	novel	novel	ADJ
bptjm-67	58	4	neuroimaging	neuroimaging	NOUN
bptjm-67	58	5	techniques	technique	NOUN
bptjm-67	58	6	recent	recent	ADJ
bptjm-67	58	7	advances	advance	NOUN
bptjm-67	58	8	in	in	ADP
bptjm-67	58	9	medical	medical	ADJ
bptjm-67	58	10	imaging	imaging	NOUN
bptjm-67	58	11	have	have	AUX
bptjm-67	58	12	paved	pave	VERB
bptjm-67	58	13	the	the	DET
bptjm-67	58	14	way	way	NOUN
bptjm-67	58	15	for	for	ADP
bptjm-67	58	16	the	the	DET
bptjm-67	58	17	detection	detection	NOUN
bptjm-67	58	18	of	of	ADP
bptjm-67	58	19	biomarkers	biomarker	NOUN
bptjm-67	58	20	and	and	CCONJ
bptjm-67	58	21	early	early	ADJ
bptjm-67	58	22	disease	disease	NOUN
bptjm-67	58	23	indicators	indicator	NOUN
bptjm-67	58	24	.	.	PUNCT
bptjm-67	59	1	neuroimaging	neuroimage	VERB
bptjm-67	59	2	plays	play	VERB
bptjm-67	59	3	a	a	DET
bptjm-67	59	4	critical	critical	ADJ
bptjm-67	59	5	role	role	NOUN
bptjm-67	59	6	in	in	ADP
bptjm-67	59	7	diagnosing	diagnose	VERB
bptjm-67	59	8	neurodegenerative	neurodegenerative	ADJ
bptjm-67	59	9	diseases	disease	NOUN
bptjm-67	59	10	,	,	PUNCT
bptjm-67	59	11	enabling	enable	VERB
bptjm-67	59	12	clinicians	clinician	NOUN
bptjm-67	59	13	to	to	PART
bptjm-67	59	14	detect	detect	VERB
bptjm-67	59	15	early	early	ADJ
bptjm-67	59	16	signs	sign	NOUN
bptjm-67	59	17	of	of	ADP
bptjm-67	59	18	cognitive	cognitive	ADJ
bptjm-67	59	19	impairment	impairment	NOUN
bptjm-67	59	20	,	,	PUNCT
bptjm-67	59	21	abnormalities	abnormality	NOUN
bptjm-67	59	22	in	in	ADP
bptjm-67	59	23	cerebral	cerebral	ADJ
bptjm-67	59	24	blood	blood	NOUN
bptjm-67	59	25	flow	flow	NOUN
bptjm-67	59	26	,	,	PUNCT
bptjm-67	59	27	and	and	CCONJ
bptjm-67	59	28	evidence	evidence	NOUN
bptjm-67	59	29	of	of	ADP
bptjm-67	59	30	stroke	stroke	NOUN
bptjm-67	59	31	,	,	PUNCT
bptjm-67	59	32	while	while	SCONJ
bptjm-67	59	33	also	also	ADV
bptjm-67	59	34	facilitating	facilitate	VERB
bptjm-67	59	35	ongoing	ongoing	ADJ
bptjm-67	59	36	disease	disease	NOUN
bptjm-67	59	37	monitoring	monitoring	NOUN
bptjm-67	59	38	.	.	PUNCT
bptjm-67	60	1	this	this	DET
bptjm-67	60	2	section	section	NOUN
bptjm-67	60	3	explores	explore	VERB
bptjm-67	60	4	several	several	ADJ
bptjm-67	60	5	state	state	NOUN
bptjm-67	60	6	-	-	PUNCT
bptjm-67	60	7	of	of	ADP
bptjm-67	60	8	-	-	PUNCT
bptjm-67	60	9	the	the	DET
bptjm-67	60	10	-	-	PUNCT
bptjm-67	60	11	art	art	NOUN
bptjm-67	60	12	techniques	technique	NOUN
bptjm-67	60	13	,	,	PUNCT
bptjm-67	60	14	including	include	VERB
bptjm-67	60	15	in	in	ADP
bptjm-67	60	16	-	-	PUNCT
bptjm-67	60	17	vivo	vivo	NOUN
bptjm-67	60	18	photon	photon	NOUN
bptjm-67	60	19	imaging	imaging	NOUN
bptjm-67	60	20	,	,	PUNCT
bptjm-67	60	21	dynamic	dynamic	ADJ
bptjm-67	60	22	vessel	vessel	NOUN
bptjm-67	60	23	analyzer	analyzer	NOUN
bptjm-67	60	24	(	(	PUNCT
bptjm-67	60	25	dva	dva	PROPN
bptjm-67	60	26	)	)	PUNCT
bptjm-67	60	27	,	,	PUNCT
bptjm-67	60	28	multimodal	multimodal	ADJ
bptjm-67	60	29	imaging	imaging	NOUN
bptjm-67	60	30	platforms	platform	NOUN
bptjm-67	60	31	,	,	PUNCT
bptjm-67	60	32	fmri	fmri	NOUN
bptjm-67	60	33	,	,	PUNCT
bptjm-67	60	34	and	and	CCONJ
bptjm-67	60	35	fnirs	fnir	NOUN
bptjm-67	60	36	.	.	PUNCT
bptjm-67	61	1	3.1	3.1	NUM
bptjm-67	61	2	in	in	ADP
bptjm-67	61	3	-	-	PUNCT
bptjm-67	61	4	vivo	vivo	NOUN
bptjm-67	61	5	photon	photon	NOUN
bptjm-67	61	6	imaging	imaging	NOUN
bptjm-67	61	7	in	in	ADP
bptjm-67	61	8	-	-	PUNCT
bptjm-67	61	9	vivo	vivo	NOUN
bptjm-67	61	10	photon	photon	NOUN
bptjm-67	61	11	imaging	imaging	NOUN
bptjm-67	61	12	is	be	AUX
bptjm-67	61	13	a	a	DET
bptjm-67	61	14	powerful	powerful	ADJ
bptjm-67	61	15	technique	technique	NOUN
bptjm-67	61	16	that	that	PRON
bptjm-67	61	17	allows	allow	VERB
bptjm-67	61	18	for	for	ADP
bptjm-67	61	19	deep	deep	ADJ
bptjm-67	61	20	-	-	PUNCT
bptjm-67	61	21	tissue	tissue	NOUN
bptjm-67	61	22	visualization	visualization	NOUN
bptjm-67	61	23	beyond	beyond	ADP
bptjm-67	61	24	the	the	DET
bptjm-67	61	25	superficial	superficial	ADJ
bptjm-67	61	26	layers	layer	NOUN
bptjm-67	61	27	of	of	ADP
bptjm-67	61	28	the	the	DET
bptjm-67	61	29	dorsal	dorsal	NOUN
bptjm-67	61	30	brain	brain	NOUN
bptjm-67	61	31	.	.	PUNCT
bptjm-67	62	1	it	it	PRON
bptjm-67	62	2	has	have	AUX
bptjm-67	62	3	been	be	AUX
bptjm-67	62	4	instrumental	instrumental	ADJ
bptjm-67	62	5	in	in	ADP
bptjm-67	62	6	identifying	identify	VERB
bptjm-67	62	7	correlations	correlation	NOUN
bptjm-67	62	8	between	between	ADP
bptjm-67	62	9	external	external	ADJ
bptjm-67	62	10	factors	factor	NOUN
bptjm-67	62	11	—	—	PUNCT
bptjm-67	62	12	such	such	ADJ
bptjm-67	62	13	as	as	ADP
bptjm-67	62	14	dietary	dietary	ADJ
bptjm-67	62	15	salt	salt	NOUN
bptjm-67	62	16	intake	intake	NOUN
bptjm-67	62	17	—	—	PUNCT
bptjm-67	62	18	and	and	CCONJ
bptjm-67	62	19	internal	internal	ADJ
bptjm-67	62	20	biomarkers	biomarker	NOUN
bptjm-67	62	21	,	,	PUNCT
bptjm-67	62	22	like	like	ADP
bptjm-67	62	23	elevated	elevate	VERB
bptjm-67	62	24	tau	tau	PROPN
bptjm-67	62	25	protein	protein	NOUN
bptjm-67	62	26	levels	level	NOUN
bptjm-67	62	27	,	,	PUNCT
bptjm-67	62	28	a	a	DET
bptjm-67	62	29	potential	potential	ADJ
bptjm-67	62	30	indicator	indicator	NOUN
bptjm-67	62	31	of	of	ADP
bptjm-67	62	32	neurodegeneration	neurodegeneration	NOUN
bptjm-67	62	33	.	.	PUNCT
bptjm-67	63	1	two	two	NUM
bptjm-67	63	2	-	-	PUNCT
bptjm-67	63	3	photon	photon	NOUN
bptjm-67	63	4	imaging	imaging	NOUN
bptjm-67	63	5	is	be	AUX
bptjm-67	63	6	a	a	DET
bptjm-67	63	7	specific	specific	ADJ
bptjm-67	63	8	type	type	NOUN
bptjm-67	63	9	of	of	ADP
bptjm-67	63	10	in	in	ADP
bptjm-67	63	11	-	-	PUNCT
bptjm-67	63	12	vivo	vivo	NOUN
bptjm-67	63	13	photon	photon	NOUN
bptjm-67	63	14	imaging	imaging	NOUN
bptjm-67	63	15	technique	technique	NOUN
bptjm-67	63	16	.	.	PUNCT
bptjm-67	64	1	this	this	DET
bptjm-67	64	2	specific	specific	ADJ
bptjm-67	64	3	technique	technique	NOUN
bptjm-67	64	4	uses	use	VERB
bptjm-67	64	5	two	two	NUM
bptjm-67	64	6	photons	photon	NOUN
bptjm-67	64	7	of	of	ADP
bptjm-67	64	8	lower	low	ADJ
bptjm-67	64	9	energy	energy	NOUN
bptjm-67	64	10	to	to	PART
bptjm-67	64	11	excite	excite	VERB
bptjm-67	64	12	a	a	DET
bptjm-67	64	13	fluorescent	fluorescent	ADJ
bptjm-67	64	14	molecule	molecule	NOUN
bptjm-67	64	15	.	.	PUNCT
bptjm-67	65	1	compared	compare	VERB
bptjm-67	65	2	to	to	ADP
bptjm-67	65	3	single	single	ADJ
bptjm-67	65	4	photon	photon	NOUN
bptjm-67	65	5	imaging	imaging	NOUN
bptjm-67	65	6	techniques	technique	NOUN
bptjm-67	65	7	,	,	PUNCT
bptjm-67	65	8	it	it	PRON
bptjm-67	65	9	allows	allow	VERB
bptjm-67	65	10	deeper	deep	ADJ
bptjm-67	65	11	tissue	tissue	NOUN
bptjm-67	65	12	penetration	penetration	NOUN
bptjm-67	65	13	and	and	CCONJ
bptjm-67	65	14	provides	provide	VERB
bptjm-67	65	15	high	high	ADJ
bptjm-67	65	16	-	-	PUNCT
bptjm-67	65	17	resolution	resolution	NOUN
bptjm-67	65	18	images	image	NOUN
bptjm-67	65	19	with	with	ADP
bptjm-67	65	20	less	less	ADJ
bptjm-67	65	21	photodamage	photodamage	NOUN
bptjm-67	65	22	.	.	PUNCT
bptjm-67	66	1	researchers	researcher	NOUN
bptjm-67	66	2	employ	employ	VERB
bptjm-67	66	3	two	two	NUM
bptjm-67	66	4	-	-	PUNCT
bptjm-67	66	5	photon	photon	NOUN
bptjm-67	66	6	microscopy	microscopy	NOUN
bptjm-67	66	7	to	to	PART
bptjm-67	66	8	track	track	VERB
bptjm-67	66	9	changes	change	NOUN
bptjm-67	66	10	in	in	ADP
bptjm-67	66	11	blood	blood	NOUN
bptjm-67	66	12	vessel	vessel	NOUN
bptjm-67	66	13	diameter	diameter	NOUN
bptjm-67	66	14	,	,	PUNCT
bptjm-67	66	15	blood	blood	NOUN
bptjm-67	66	16	flow	flow	NOUN
bptjm-67	66	17	,	,	PUNCT
bptjm-67	66	18	and	and	CCONJ
bptjm-67	66	19	oxygenation	oxygenation	NOUN
bptjm-67	66	20	levels	level	NOUN
bptjm-67	66	21	in	in	ADP
bptjm-67	66	22	response	response	NOUN
bptjm-67	66	23	to	to	ADP
bptjm-67	66	24	neuronal	neuronal	ADJ
bptjm-67	66	25	activity.18	activity.18	PROPN
bptjm-67	66	26	berkeley	berkeley	PROPN
bptjm-67	66	27	pharma	pharma	PROPN
bptjm-67	66	28	tech	tech	NOUN
bptjm-67	66	29	journal	journal	NOUN
bptjm-67	66	30	of	of	ADP
bptjm-67	66	31	medicine	medicine	NOUN
bptjm-67	66	32	|	|	ADV
bptjm-67	66	33	130	130	NUM
bptjm-67	66	34	figure	figure	NOUN
bptjm-67	66	35	6	6	NUM
bptjm-67	66	36	:	:	PUNCT
bptjm-67	66	37	schematic	schematic	ADJ
bptjm-67	66	38	of	of	ADP
bptjm-67	66	39	a	a	DET
bptjm-67	66	40	2pf	2pf	ADJ
bptjm-67	66	41	microscope	microscope	NOUN
bptjm-67	66	42	.	.	PUNCT
bptjm-67	67	1	a	a	DET
bptjm-67	67	2	two	two	NUM
bptjm-67	67	3	-	-	PUNCT
bptjm-67	67	4	photon	photon	NOUN
bptjm-67	67	5	fluorescence	fluorescence	NOUN
bptjm-67	67	6	microscope	microscope	NOUN
bptjm-67	67	7	utilizes	utilize	VERB
bptjm-67	67	8	a	a	DET
bptjm-67	67	9	femtosecond	femtosecond	NOUN
bptjm-67	67	10	laser	laser	NOUN
bptjm-67	67	11	to	to	PART
bptjm-67	67	12	send	send	VERB
bptjm-67	67	13	light	light	NOUN
bptjm-67	67	14	through	through	ADP
bptjm-67	67	15	xy	xy	PROPN
bptjm-67	67	16	-	-	PUNCT
bptjm-67	67	17	scan	scan	ADJ
bptjm-67	67	18	mirrors	mirror	NOUN
bptjm-67	67	19	,	,	PUNCT
bptjm-67	67	20	scan	scan	ADJ
bptjm-67	67	21	and	and	CCONJ
bptjm-67	67	22	tube	tube	NOUN
bptjm-67	67	23	lenses	lense	NOUN
bptjm-67	67	24	,	,	PUNCT
bptjm-67	67	25	focusing	focus	VERB
bptjm-67	67	26	on	on	ADP
bptjm-67	67	27	a	a	DET
bptjm-67	67	28	sample	sample	NOUN
bptjm-67	67	29	with	with	ADP
bptjm-67	67	30	an	an	DET
bptjm-67	67	31	objective	objective	ADJ
bptjm-67	67	32	lens	len	NOUN
bptjm-67	67	33	.	.	PUNCT
bptjm-67	68	1	this	this	PRON
bptjm-67	68	2	induces	induce	VERB
bptjm-67	68	3	fluorescence	fluorescence	NOUN
bptjm-67	68	4	in	in	ADP
bptjm-67	68	5	the	the	DET
bptjm-67	68	6	sample	sample	NOUN
bptjm-67	68	7	,	,	PUNCT
bptjm-67	68	8	which	which	PRON
bptjm-67	68	9	is	be	AUX
bptjm-67	68	10	then	then	ADV
bptjm-67	68	11	collected	collect	VERB
bptjm-67	68	12	back	back	ADV
bptjm-67	68	13	through	through	ADP
bptjm-67	68	14	the	the	DET
bptjm-67	68	15	objective	objective	ADJ
bptjm-67	68	16	lens	lens	NOUN
bptjm-67	68	17	,	,	PUNCT
bptjm-67	68	18	filtered	filter	VERB
bptjm-67	68	19	by	by	ADP
bptjm-67	68	20	a	a	DET
bptjm-67	68	21	dichroic	dichroic	ADJ
bptjm-67	68	22	mirror	mirror	NOUN
bptjm-67	68	23	,	,	PUNCT
bptjm-67	68	24	and	and	CCONJ
bptjm-67	68	25	detected	detect	VERB
bptjm-67	68	26	by	by	ADP
bptjm-67	68	27	a	a	DET
bptjm-67	68	28	photomultiplier	photomultiplier	NOUN
bptjm-67	68	29	tube	tube	NOUN
bptjm-67	68	30	,	,	PUNCT
bptjm-67	68	31	ultimately	ultimately	ADV
bptjm-67	68	32	translating	translate	VERB
bptjm-67	68	33	into	into	ADP
bptjm-67	68	34	an	an	DET
bptjm-67	68	35	image	image	NOUN
bptjm-67	68	36	by	by	ADP
bptjm-67	68	37	a	a	DET
bptjm-67	68	38	computer	computer	NOUN
bptjm-67	68	39	.	.	PUNCT
bptjm-67	69	1	3.2	3.2	NUM
bptjm-67	69	2	dynamic	dynamic	ADJ
bptjm-67	69	3	vessel	vessel	NOUN
bptjm-67	69	4	analyzer	analyzer	NOUN
bptjm-67	69	5	in	in	ADP
bptjm-67	69	6	one	one	NUM
bptjm-67	69	7	study	study	NOUN
bptjm-67	69	8	,	,	PUNCT
bptjm-67	69	9	patients	patient	NOUN
bptjm-67	69	10	with	with	ADP
bptjm-67	69	11	varying	vary	VERB
bptjm-67	69	12	degrees	degree	NOUN
bptjm-67	69	13	of	of	ADP
bptjm-67	69	14	alzheimer	alzheimer	PROPN
bptjm-67	69	15	’s	’s	PART
bptjm-67	69	16	disease	disease	NOUN
bptjm-67	69	17	were	be	AUX
bptjm-67	69	18	compared	compare	VERB
bptjm-67	69	19	to	to	ADP
bptjm-67	69	20	controls	control	NOUN
bptjm-67	69	21	by	by	ADP
bptjm-67	69	22	assessing	assess	VERB
bptjm-67	69	23	the	the	DET
bptjm-67	69	24	retinal	retinal	ADJ
bptjm-67	69	25	blood	blood	NOUN
bptjm-67	69	26	vessel	vessel	NOUN
bptjm-67	69	27	response	response	NOUN
bptjm-67	69	28	to	to	ADP
bptjm-67	69	29	flickering	flickering	NOUN
bptjm-67	69	30	lights	light	NOUN
bptjm-67	69	31	.	.	PUNCT
bptjm-67	70	1	retinal	retinal	ADJ
bptjm-67	70	2	vasculature	vasculature	NOUN
bptjm-67	70	3	is	be	AUX
bptjm-67	70	4	a	a	DET
bptjm-67	70	5	valid	valid	ADJ
bptjm-67	70	6	proxy	proxy	NOUN
bptjm-67	70	7	for	for	ADP
bptjm-67	70	8	cerebral	cerebral	ADJ
bptjm-67	70	9	blood	blood	NOUN
bptjm-67	70	10	flow	flow	NOUN
bptjm-67	70	11	since	since	SCONJ
bptjm-67	70	12	they	they	PRON
bptjm-67	70	13	share	share	VERB
bptjm-67	70	14	anatomical	anatomical	ADJ
bptjm-67	70	15	and	and	CCONJ
bptjm-67	70	16	physiological	physiological	ADJ
bptjm-67	70	17	features	feature	NOUN
bptjm-67	70	18	that	that	PRON
bptjm-67	70	19	stem	stem	VERB
bptjm-67	70	20	from	from	ADP
bptjm-67	70	21	a	a	DET
bptjm-67	70	22	shared	share	VERB
bptjm-67	70	23	embryonic	embryonic	ADJ
bptjm-67	70	24	origin	origin	NOUN
bptjm-67	70	25	.	.	PUNCT
bptjm-67	71	1	to	to	PART
bptjm-67	71	2	assess	assess	VERB
bptjm-67	71	3	these	these	DET
bptjm-67	71	4	responses	response	NOUN
bptjm-67	71	5	,	,	PUNCT
bptjm-67	71	6	scientists	scientist	NOUN
bptjm-67	71	7	used	use	VERB
bptjm-67	71	8	the	the	DET
bptjm-67	71	9	dynamic	dynamic	ADJ
bptjm-67	71	10	vessel	vessel	NOUN
bptjm-67	71	11	analyzer	analyzer	NOUN
bptjm-67	71	12	(	(	PUNCT
bptjm-67	71	13	dva)—a	dva)—a	ADJ
bptjm-67	71	14	novel	novel	ADJ
bptjm-67	71	15	imaging	imaging	NOUN
bptjm-67	71	16	tool	tool	NOUN
bptjm-67	71	17	that	that	PRON
bptjm-67	71	18	captures	capture	VERB
bptjm-67	71	19	microvascular	microvascular	ADJ
bptjm-67	71	20	dynamics	dynamic	NOUN
bptjm-67	71	21	in	in	ADP
bptjm-67	71	22	the	the	DET
bptjm-67	71	23	eye	eye	NOUN
bptjm-67	71	24	.	.	PUNCT
bptjm-67	72	1	as	as	ADP
bptjm-67	72	2	a	a	DET
bptjm-67	72	3	non	non	ADJ
bptjm-67	72	4	-	-	ADJ
bptjm-67	72	5	invasive	invasive	ADJ
bptjm-67	72	6	proxy	proxy	NOUN
bptjm-67	72	7	for	for	ADP
bptjm-67	72	8	cerebral	cerebral	ADJ
bptjm-67	72	9	vasculature	vasculature	NOUN
bptjm-67	72	10	,	,	PUNCT
bptjm-67	72	11	the	the	DET
bptjm-67	72	12	dva	dva	PROPN
bptjm-67	72	13	provides	provide	VERB
bptjm-67	72	14	valuable	valuable	ADJ
bptjm-67	72	15	insights	insight	NOUN
bptjm-67	72	16	into	into	ADP
bptjm-67	72	17	neurovascular	neurovascular	ADJ
bptjm-67	72	18	function	function	NOUN
bptjm-67	72	19	.	.	PUNCT
bptjm-67	73	1	results	result	NOUN
bptjm-67	73	2	revealed	reveal	VERB
bptjm-67	73	3	that	that	SCONJ
bptjm-67	73	4	patients	patient	NOUN
bptjm-67	73	5	with	with	ADP
bptjm-67	73	6	moderate	moderate	ADJ
bptjm-67	73	7	or	or	CCONJ
bptjm-67	73	8	mild	mild	ADJ
bptjm-67	73	9	dementia	dementia	NOUN
bptjm-67	73	10	from	from	ADP
bptjm-67	73	11	alzheimer	alzheimer	PROPN
bptjm-67	73	12	’s	’s	PART
bptjm-67	73	13	had	have	AUX
bptjm-67	73	14	emphasized	emphasize	VERB
bptjm-67	73	15	arterial	arterial	NOUN
bptjm-67	73	16	and	and	CCONJ
bptjm-67	73	17	venous	venous	ADJ
bptjm-67	73	18	dilation	dilation	NOUN
bptjm-67	73	19	,	,	PUNCT
bptjm-67	73	20	as	as	ADV
bptjm-67	73	21	well	well	ADV
bptjm-67	73	22	as	as	ADP
bptjm-67	73	23	delayed	delay	VERB
bptjm-67	73	24	arterial	arterial	ADJ
bptjm-67	73	25	reaction	reaction	NOUN
bptjm-67	73	26	to	to	ADP
bptjm-67	73	27	the	the	DET
bptjm-67	73	28	flickering	flickering	NOUN
bptjm-67	73	29	lights	light	NOUN
bptjm-67	73	30	.	.	PUNCT
bptjm-67	74	1	these	these	DET
bptjm-67	74	2	findings	finding	NOUN
bptjm-67	74	3	suggest	suggest	VERB
bptjm-67	74	4	that	that	SCONJ
bptjm-67	74	5	increased	increase	VERB
bptjm-67	74	6	and	and	CCONJ
bptjm-67	74	7	delayed	delay	VERB
bptjm-67	74	8	retinal	retinal	ADJ
bptjm-67	74	9	neurovascular	neurovascular	ADJ
bptjm-67	74	10	coupling	coupling	NOUN
bptjm-67	74	11	,	,	PUNCT
bptjm-67	74	12	perhaps	perhaps	ADV
bptjm-67	74	13	caused	cause	VERB
bptjm-67	74	14	by	by	ADP
bptjm-67	74	15	damaged	damage	VERB
bptjm-67	74	16	feedback	feedback	NOUN
bptjm-67	74	17	loops	loop	NOUN
bptjm-67	74	18	or	or	CCONJ
bptjm-67	74	19	excessive	excessive	ADJ
bptjm-67	74	20	activity	activity	NOUN
bptjm-67	74	21	of	of	ADP
bptjm-67	74	22	retinal	retinal	ADJ
bptjm-67	74	23	neurons	neuron	NOUN
bptjm-67	74	24	,	,	PUNCT
bptjm-67	74	25	is	be	AUX
bptjm-67	74	26	associated	associate	VERB
bptjm-67	74	27	with	with	ADP
bptjm-67	74	28	alzheimer	alzheimer	PROPN
bptjm-67	74	29	’s	’s	PART
bptjm-67	74	30	.	.	PUNCT
bptjm-67	75	1	as	as	ADP
bptjm-67	75	2	a	a	DET
bptjm-67	75	3	non	non	ADJ
bptjm-67	75	4	-	-	ADJ
bptjm-67	75	5	invasive	invasive	ADJ
bptjm-67	75	6	and	and	CCONJ
bptjm-67	75	7	accessible	accessible	ADJ
bptjm-67	75	8	diagnostic	diagnostic	ADJ
bptjm-67	75	9	tool	tool	NOUN
bptjm-67	75	10	,	,	PUNCT
bptjm-67	75	11	the	the	DET
bptjm-67	75	12	dva	dva	PROPN
bptjm-67	75	13	berkeley	berkeley	PROPN
bptjm-67	75	14	pharma	pharma	PROPN
bptjm-67	75	15	tech	tech	NOUN
bptjm-67	75	16	journal	journal	NOUN
bptjm-67	75	17	of	of	ADP
bptjm-67	75	18	medicine	medicine	NOUN
bptjm-67	75	19	|	|	ADV
bptjm-67	75	20	131	131	NUM
bptjm-67	75	21	holds	hold	VERB
bptjm-67	75	22	promise	promise	NOUN
bptjm-67	75	23	for	for	ADP
bptjm-67	75	24	monitoring	monitor	VERB
bptjm-67	75	25	retinal	retinal	ADJ
bptjm-67	75	26	and	and	CCONJ
bptjm-67	75	27	vascular	vascular	ADJ
bptjm-67	75	28	changes	change	NOUN
bptjm-67	75	29	linked	link	VERB
bptjm-67	75	30	to	to	ADP
bptjm-67	75	31	alzheimer	alzheimer	PROPN
bptjm-67	75	32	’s	’s	PART
bptjm-67	75	33	disease	disease	NOUN
bptjm-67	75	34	and	and	CCONJ
bptjm-67	75	35	may	may	AUX
bptjm-67	75	36	aid	aid	VERB
bptjm-67	75	37	in	in	ADP
bptjm-67	75	38	tracking	tracking	NOUN
bptjm-67	75	39	disease	disease	NOUN
bptjm-67	75	40	progression.19	progression.19	NOUN
bptjm-67	75	41	figure	figure	VERB
bptjm-67	75	42	7	7	NUM
bptjm-67	75	43	:	:	PUNCT
bptjm-67	75	44	static	static	ADJ
bptjm-67	75	45	analysis	analysis	NOUN
bptjm-67	75	46	performed	perform	VERB
bptjm-67	75	47	by	by	ADP
bptjm-67	75	48	the	the	DET
bptjm-67	75	49	dynamic	dynamic	ADJ
bptjm-67	75	50	vessel	vessel	NOUN
bptjm-67	75	51	analyzer	analyzer	NOUN
bptjm-67	75	52	.	.	PUNCT
bptjm-67	76	1	the	the	DET
bptjm-67	76	2	technology	technology	NOUN
bptjm-67	76	3	gives	give	VERB
bptjm-67	76	4	valuable	valuable	ADJ
bptjm-67	76	5	glimpses	glimpse	NOUN
bptjm-67	76	6	into	into	ADP
bptjm-67	76	7	arterioles	arterioles	PROPN
bptjm-67	76	8	(	(	PUNCT
bptjm-67	76	9	red	red	ADJ
bptjm-67	76	10	segments	segment	NOUN
bptjm-67	76	11	)	)	PUNCT
bptjm-67	76	12	and	and	CCONJ
bptjm-67	76	13	venules	venule	NOUN
bptjm-67	76	14	(	(	PUNCT
bptjm-67	76	15	blue	blue	ADJ
bptjm-67	76	16	segments	segment	NOUN
bptjm-67	76	17	)	)	PUNCT
bptjm-67	76	18	3.3	3.3	NUM
bptjm-67	76	19	multimodality	multimodality	NOUN
bptjm-67	76	20	imaging	imaging	NOUN
bptjm-67	76	21	platforms	platform	NOUN
bptjm-67	76	22	traditional	traditional	ADJ
bptjm-67	76	23	high	high	ADJ
bptjm-67	76	24	-	-	PUNCT
bptjm-67	76	25	resolution	resolution	NOUN
bptjm-67	76	26	microscopy	microscopy	NOUN
bptjm-67	76	27	offers	offer	VERB
bptjm-67	76	28	excellent	excellent	ADJ
bptjm-67	76	29	detail	detail	NOUN
bptjm-67	76	30	but	but	CCONJ
bptjm-67	76	31	is	be	AUX
bptjm-67	76	32	limited	limit	VERB
bptjm-67	76	33	by	by	ADP
bptjm-67	76	34	its	its	PRON
bptjm-67	76	35	small	small	ADJ
bptjm-67	76	36	field	field	NOUN
bptjm-67	76	37	of	of	ADP
bptjm-67	76	38	view	view	NOUN
bptjm-67	76	39	.	.	PUNCT
bptjm-67	77	1	to	to	PART
bptjm-67	77	2	overcome	overcome	VERB
bptjm-67	77	3	this	this	DET
bptjm-67	77	4	limitation	limitation	NOUN
bptjm-67	77	5	,	,	PUNCT
bptjm-67	77	6	researchers	researcher	NOUN
bptjm-67	77	7	in	in	ADP
bptjm-67	77	8	one	one	NUM
bptjm-67	77	9	study	study	NOUN
bptjm-67	77	10	employed	employ	VERB
bptjm-67	77	11	a	a	DET
bptjm-67	77	12	multimodality	multimodality	NOUN
bptjm-67	77	13	imaging	imaging	NOUN
bptjm-67	77	14	approach	approach	NOUN
bptjm-67	77	15	to	to	PART
bptjm-67	77	16	investigate	investigate	VERB
bptjm-67	77	17	the	the	DET
bptjm-67	77	18	role	role	NOUN
bptjm-67	77	19	of	of	ADP
bptjm-67	77	20	calcium	calcium	NOUN
bptjm-67	77	21	ion	ion	NOUN
bptjm-67	77	22	(	(	PUNCT
bptjm-67	77	23	ca²⁺	ca²⁺	NOUN
bptjm-67	77	24	)	)	PUNCT
bptjm-67	77	25	fluctuations	fluctuation	NOUN
bptjm-67	77	26	in	in	ADP
bptjm-67	77	27	astrocytes	astrocyte	NOUN
bptjm-67	77	28	,	,	PUNCT
bptjm-67	77	29	key	key	ADJ
bptjm-67	77	30	glial	glial	ADJ
bptjm-67	77	31	cells	cell	NOUN
bptjm-67	77	32	involved	involve	VERB
bptjm-67	77	33	in	in	ADP
bptjm-67	77	34	maintaining	maintain	VERB
bptjm-67	77	35	the	the	DET
bptjm-67	77	36	nvu	nvu	NOUN
bptjm-67	77	37	.	.	PUNCT
bptjm-67	78	1	using	use	VERB
bptjm-67	78	2	electrical	electrical	ADJ
bptjm-67	78	3	stimulation	stimulation	NOUN
bptjm-67	78	4	in	in	ADP
bptjm-67	78	5	mice	mouse	NOUN
bptjm-67	78	6	,	,	PUNCT
bptjm-67	78	7	researchers	researcher	NOUN
bptjm-67	78	8	observed	observe	VERB
bptjm-67	78	9	that	that	SCONJ
bptjm-67	78	10	astrocytes	astrocyte	NOUN
bptjm-67	78	11	exhibited	exhibit	VERB
bptjm-67	78	12	a	a	DET
bptjm-67	78	13	delayed	delay	VERB
bptjm-67	78	14	response	response	NOUN
bptjm-67	78	15	to	to	ADP
bptjm-67	78	16	stimulation	stimulation	NOUN
bptjm-67	78	17	,	,	PUNCT
bptjm-67	78	18	while	while	SCONJ
bptjm-67	78	19	cerebral	cerebral	ADJ
bptjm-67	78	20	blood	blood	NOUN
bptjm-67	78	21	flow	flow	NOUN
bptjm-67	78	22	increased	increase	VERB
bptjm-67	78	23	rapidly	rapidly	ADV
bptjm-67	78	24	.	.	PUNCT
bptjm-67	79	1	this	this	DET
bptjm-67	79	2	finding	finding	NOUN
bptjm-67	79	3	suggests	suggest	VERB
bptjm-67	79	4	that	that	SCONJ
bptjm-67	79	5	astrocytes	astrocyte	NOUN
bptjm-67	79	6	contribute	contribute	VERB
bptjm-67	79	7	to	to	ADP
bptjm-67	79	8	the	the	DET
bptjm-67	79	9	coupling	coupling	NOUN
bptjm-67	79	10	between	between	ADP
bptjm-67	79	11	neuronal	neuronal	ADJ
bptjm-67	79	12	activity	activity	NOUN
bptjm-67	79	13	and	and	CCONJ
bptjm-67	79	14	blood	blood	NOUN
bptjm-67	79	15	flow	flow	NOUN
bptjm-67	79	16	.	.	PUNCT
bptjm-67	80	1	additionally	additionally	ADV
bptjm-67	80	2	,	,	PUNCT
bptjm-67	80	3	the	the	DET
bptjm-67	80	4	stimulation	stimulation	NOUN
bptjm-67	80	5	induced	induce	VERB
bptjm-67	80	6	vasoconstriction	vasoconstriction	NOUN
bptjm-67	80	7	—	—	PUNCT
bptjm-67	80	8	the	the	DET
bptjm-67	80	9	narrowing	narrowing	NOUN
bptjm-67	80	10	of	of	ADP
bptjm-67	80	11	blood	blood	NOUN
bptjm-67	80	12	vessels	vessel	NOUN
bptjm-67	80	13	—	—	PUNCT
bptjm-67	80	14	indicating	indicate	VERB
bptjm-67	80	15	that	that	SCONJ
bptjm-67	80	16	astrocytes	astrocyte	NOUN
bptjm-67	80	17	may	may	AUX
bptjm-67	80	18	regulate	regulate	VERB
bptjm-67	80	19	blood	blood	NOUN
bptjm-67	80	20	flow	flow	NOUN
bptjm-67	80	21	not	not	PART
bptjm-67	80	22	only	only	ADV
bptjm-67	80	23	during	during	ADP
bptjm-67	80	24	periods	period	NOUN
bptjm-67	80	25	of	of	ADP
bptjm-67	80	26	high	high	ADJ
bptjm-67	80	27	neural	neural	ADJ
bptjm-67	80	28	activity	activity	NOUN
bptjm-67	80	29	but	but	CCONJ
bptjm-67	80	30	also	also	ADV
bptjm-67	80	31	at	at	ADP
bptjm-67	80	32	rest	rest	NOUN
bptjm-67	80	33	.	.	PUNCT
bptjm-67	81	1	by	by	ADP
bptjm-67	81	2	integrating	integrate	VERB
bptjm-67	81	3	multiple	multiple	ADJ
bptjm-67	81	4	imaging	imaging	NOUN
bptjm-67	81	5	modalities	modality	NOUN
bptjm-67	81	6	,	,	PUNCT
bptjm-67	81	7	the	the	DET
bptjm-67	81	8	study	study	NOUN
bptjm-67	81	9	provided	provide	VERB
bptjm-67	81	10	a	a	DET
bptjm-67	81	11	more	more	ADV
bptjm-67	81	12	comprehensive	comprehensive	ADJ
bptjm-67	81	13	berkeley	berkeley	PROPN
bptjm-67	81	14	pharma	pharma	PROPN
bptjm-67	81	15	tech	tech	NOUN
bptjm-67	81	16	journal	journal	NOUN
bptjm-67	81	17	of	of	ADP
bptjm-67	81	18	medicine	medicine	NOUN
bptjm-67	81	19	|	|	ADV
bptjm-67	81	20	132	132	NUM
bptjm-67	81	21	understanding	understanding	NOUN
bptjm-67	81	22	of	of	ADP
bptjm-67	81	23	astrocytic	astrocytic	ADJ
bptjm-67	81	24	function	function	NOUN
bptjm-67	81	25	in	in	ADP
bptjm-67	81	26	cerebral	cerebral	ADJ
bptjm-67	81	27	perfusion	perfusion	NOUN
bptjm-67	81	28	and	and	CCONJ
bptjm-67	81	29	cognitive	cognitive	ADJ
bptjm-67	81	30	maintenance.20	maintenance.20	NOUN
bptjm-67	81	31	3.4	3.4	NUM
bptjm-67	81	32	fmri	fmri	NOUN
bptjm-67	81	33	(	(	PUNCT
bptjm-67	81	34	functional	functional	ADJ
bptjm-67	81	35	magnetic	magnetic	ADJ
bptjm-67	81	36	resonance	resonance	NOUN
bptjm-67	81	37	imaging	imaging	NOUN
bptjm-67	81	38	)	)	PUNCT
bptjm-67	81	39	fmri	fmri	NOUN
bptjm-67	81	40	is	be	AUX
bptjm-67	81	41	a	a	DET
bptjm-67	81	42	widely	widely	ADV
bptjm-67	81	43	used	use	VERB
bptjm-67	81	44	,	,	PUNCT
bptjm-67	81	45	non	non	ADJ
bptjm-67	81	46	-	-	ADJ
bptjm-67	81	47	invasive	invasive	ADJ
bptjm-67	81	48	technique	technique	NOUN
bptjm-67	81	49	for	for	ADP
bptjm-67	81	50	visualizing	visualize	VERB
bptjm-67	81	51	brain	brain	NOUN
bptjm-67	81	52	activity	activity	NOUN
bptjm-67	81	53	by	by	ADP
bptjm-67	81	54	measuring	measure	VERB
bptjm-67	81	55	changes	change	NOUN
bptjm-67	81	56	in	in	ADP
bptjm-67	81	57	blood	blood	NOUN
bptjm-67	81	58	oxygenation	oxygenation	NOUN
bptjm-67	81	59	levels	level	NOUN
bptjm-67	81	60	.	.	PUNCT
bptjm-67	82	1	it	it	PRON
bptjm-67	82	2	relies	rely	VERB
bptjm-67	82	3	on	on	ADP
bptjm-67	82	4	bold	bold	ADJ
bptjm-67	82	5	(	(	PUNCT
bptjm-67	82	6	blood	blood	NOUN
bptjm-67	82	7	-	-	PUNCT
bptjm-67	82	8	oxygen	oxygen	NOUN
bptjm-67	82	9	-	-	PUNCT
bptjm-67	82	10	level	level	NOUN
bptjm-67	82	11	-	-	PUNCT
bptjm-67	82	12	dependent	dependent	ADJ
bptjm-67	82	13	)	)	PUNCT
bptjm-67	82	14	contrast	contrast	NOUN
bptjm-67	82	15	,	,	PUNCT
bptjm-67	82	16	which	which	PRON
bptjm-67	82	17	detects	detect	VERB
bptjm-67	82	18	variations	variation	NOUN
bptjm-67	82	19	in	in	ADP
bptjm-67	82	20	the	the	DET
bptjm-67	82	21	magnetic	magnetic	ADJ
bptjm-67	82	22	properties	property	NOUN
bptjm-67	82	23	of	of	ADP
bptjm-67	82	24	oxygenated	oxygenated	ADJ
bptjm-67	82	25	and	and	CCONJ
bptjm-67	82	26	deoxygenated	deoxygenate	VERB
bptjm-67	82	27	hemoglobin	hemoglobin	NOUN
bptjm-67	82	28	.	.	PUNCT
bptjm-67	83	1	fmri	fmri	PROPN
bptjm-67	83	2	is	be	AUX
bptjm-67	83	3	repeatable	repeatable	ADJ
bptjm-67	83	4	,	,	PUNCT
bptjm-67	83	5	widely	widely	ADV
bptjm-67	83	6	available	available	ADJ
bptjm-67	83	7	,	,	PUNCT
bptjm-67	83	8	and	and	CCONJ
bptjm-67	83	9	offers	offer	VERB
bptjm-67	83	10	superior	superior	ADJ
bptjm-67	83	11	spatial	spatial	ADJ
bptjm-67	83	12	resolution	resolution	NOUN
bptjm-67	83	13	compared	compare	VERB
bptjm-67	83	14	to	to	ADP
bptjm-67	83	15	other	other	ADJ
bptjm-67	83	16	neuroimaging	neuroimaging	ADJ
bptjm-67	83	17	methods	method	NOUN
bptjm-67	83	18	.	.	PUNCT
bptjm-67	84	1	it	it	PRON
bptjm-67	84	2	enables	enable	VERB
bptjm-67	84	3	in	in	ADP
bptjm-67	84	4	-	-	PUNCT
bptjm-67	84	5	depth	depth	NOUN
bptjm-67	84	6	,	,	PUNCT
bptjm-67	84	7	whole	whole	ADJ
bptjm-67	84	8	-	-	PUNCT
bptjm-67	84	9	brain	brain	NOUN
bptjm-67	84	10	analysis	analysis	NOUN
bptjm-67	84	11	of	of	ADP
bptjm-67	84	12	functional	functional	ADJ
bptjm-67	84	13	activity	activity	NOUN
bptjm-67	84	14	.	.	PUNCT
bptjm-67	85	1	however	however	ADV
bptjm-67	85	2	,	,	PUNCT
bptjm-67	85	3	fmri	fmri	PROPN
bptjm-67	85	4	has	have	VERB
bptjm-67	85	5	limitations	limitation	NOUN
bptjm-67	85	6	:	:	PUNCT
bptjm-67	85	7	it	it	PRON
bptjm-67	85	8	is	be	AUX
bptjm-67	85	9	contraindicated	contraindicate	VERB
bptjm-67	85	10	for	for	ADP
bptjm-67	85	11	individuals	individual	NOUN
bptjm-67	85	12	with	with	ADP
bptjm-67	85	13	metal	metal	NOUN
bptjm-67	85	14	implants	implant	NOUN
bptjm-67	85	15	or	or	CCONJ
bptjm-67	85	16	devices	device	NOUN
bptjm-67	85	17	from	from	ADP
bptjm-67	85	18	prior	prior	ADJ
bptjm-67	85	19	medical	medical	ADJ
bptjm-67	85	20	procedures	procedure	NOUN
bptjm-67	85	21	,	,	PUNCT
bptjm-67	85	22	and	and	CCONJ
bptjm-67	85	23	its	its	PRON
bptjm-67	85	24	sensitivity	sensitivity	NOUN
bptjm-67	85	25	to	to	ADP
bptjm-67	85	26	movement	movement	NOUN
bptjm-67	85	27	makes	make	VERB
bptjm-67	85	28	it	it	PRON
bptjm-67	85	29	less	less	ADV
bptjm-67	85	30	suitable	suitable	ADJ
bptjm-67	85	31	for	for	ADP
bptjm-67	85	32	use	use	NOUN
bptjm-67	85	33	during	during	ADP
bptjm-67	85	34	physical	physical	ADJ
bptjm-67	85	35	activity	activity	NOUN
bptjm-67	85	36	or	or	CCONJ
bptjm-67	85	37	with	with	ADP
bptjm-67	85	38	populations	population	NOUN
bptjm-67	85	39	such	such	ADJ
bptjm-67	85	40	as	as	ADP
bptjm-67	85	41	infants	infant	NOUN
bptjm-67	85	42	.	.	PUNCT
bptjm-67	86	1	3.5	3.5	NUM
bptjm-67	86	2	fnirs	fnir	NOUN
bptjm-67	86	3	(	(	PUNCT
bptjm-67	86	4	functional	functional	ADJ
bptjm-67	86	5	near	near	ADV
bptjm-67	86	6	-	-	PUNCT
bptjm-67	86	7	infrared	infrared	ADJ
bptjm-67	86	8	spectroscopy	spectroscopy	NOUN
bptjm-67	86	9	)	)	PUNCT
bptjm-67	86	10	although	although	SCONJ
bptjm-67	86	11	fmri	fmri	PROPN
bptjm-67	86	12	is	be	AUX
bptjm-67	86	13	considered	consider	VERB
bptjm-67	86	14	one	one	NUM
bptjm-67	86	15	of	of	ADP
bptjm-67	86	16	the	the	DET
bptjm-67	86	17	most	most	ADV
bptjm-67	86	18	advanced	advanced	ADJ
bptjm-67	86	19	neuroimaging	neuroimaging	NOUN
bptjm-67	86	20	modalities	modality	NOUN
bptjm-67	86	21	,	,	PUNCT
bptjm-67	86	22	functional	functional	ADJ
bptjm-67	86	23	near	near	ADV
bptjm-67	86	24	-	-	PUNCT
bptjm-67	86	25	infrared	infrared	ADJ
bptjm-67	86	26	spectroscopy	spectroscopy	NOUN
bptjm-67	86	27	(	(	PUNCT
bptjm-67	86	28	fnirs	fnir	NOUN
bptjm-67	86	29	)	)	PUNCT
bptjm-67	86	30	has	have	AUX
bptjm-67	86	31	emerged	emerge	VERB
bptjm-67	86	32	as	as	ADP
bptjm-67	86	33	a	a	DET
bptjm-67	86	34	promising	promising	ADJ
bptjm-67	86	35	alternative	alternative	ADJ
bptjm-67	86	36	or	or	CCONJ
bptjm-67	86	37	complementary	complementary	ADJ
bptjm-67	86	38	technique	technique	NOUN
bptjm-67	86	39	.	.	PUNCT
bptjm-67	87	1	like	like	ADP
bptjm-67	87	2	fmri	fmri	PROPN
bptjm-67	87	3	,	,	PUNCT
bptjm-67	87	4	fnirs	fnir	NOUN
bptjm-67	87	5	is	be	AUX
bptjm-67	87	6	non	non	ADJ
bptjm-67	87	7	-	-	ADJ
bptjm-67	87	8	invasive	invasive	ADJ
bptjm-67	87	9	and	and	CCONJ
bptjm-67	87	10	measures	measure	VERB
bptjm-67	87	11	hemodynamic	hemodynamic	ADJ
bptjm-67	87	12	responses	response	NOUN
bptjm-67	87	13	in	in	ADP
bptjm-67	87	14	the	the	DET
bptjm-67	87	15	brain	brain	NOUN
bptjm-67	87	16	,	,	PUNCT
bptjm-67	87	17	but	but	CCONJ
bptjm-67	87	18	it	it	PRON
bptjm-67	87	19	does	do	AUX
bptjm-67	87	20	so	so	ADV
bptjm-67	87	21	using	use	VERB
bptjm-67	87	22	near	near	ADV
bptjm-67	87	23	-	-	PUNCT
bptjm-67	87	24	infrared	infrared	ADJ
bptjm-67	87	25	light	light	NOUN
bptjm-67	87	26	instead	instead	ADV
bptjm-67	87	27	of	of	ADP
bptjm-67	87	28	magnetic	magnetic	ADJ
bptjm-67	87	29	fields	field	NOUN
bptjm-67	87	30	.	.	PUNCT
bptjm-67	88	1	fnirs	fnir	NOUN
bptjm-67	88	2	is	be	AUX
bptjm-67	88	3	relatively	relatively	ADV
bptjm-67	88	4	inexpensive	inexpensive	ADJ
bptjm-67	88	5	,	,	PUNCT
bptjm-67	88	6	portable	portable	ADJ
bptjm-67	88	7	,	,	PUNCT
bptjm-67	88	8	and	and	CCONJ
bptjm-67	88	9	tolerant	tolerant	ADJ
bptjm-67	88	10	to	to	ADP
bptjm-67	88	11	motion	motion	NOUN
bptjm-67	88	12	,	,	PUNCT
bptjm-67	88	13	making	make	VERB
bptjm-67	88	14	it	it	PRON
bptjm-67	88	15	suitable	suitable	ADJ
bptjm-67	88	16	for	for	ADP
bptjm-67	88	17	dynamic	dynamic	ADJ
bptjm-67	88	18	settings	setting	NOUN
bptjm-67	88	19	and	and	CCONJ
bptjm-67	88	20	use	use	NOUN
bptjm-67	88	21	in	in	ADP
bptjm-67	88	22	young	young	ADJ
bptjm-67	88	23	or	or	CCONJ
bptjm-67	88	24	mobile	mobile	ADJ
bptjm-67	88	25	populations	population	NOUN
bptjm-67	88	26	.	.	PUNCT
bptjm-67	89	1	however	however	ADV
bptjm-67	89	2	,	,	PUNCT
bptjm-67	89	3	it	it	PRON
bptjm-67	89	4	has	have	VERB
bptjm-67	89	5	limitations	limitation	NOUN
bptjm-67	89	6	in	in	ADP
bptjm-67	89	7	terms	term	NOUN
bptjm-67	89	8	of	of	ADP
bptjm-67	89	9	probe	probe	NOUN
bptjm-67	89	10	placement	placement	NOUN
bptjm-67	89	11	and	and	CCONJ
bptjm-67	89	12	depth	depth	NOUN
bptjm-67	89	13	of	of	ADP
bptjm-67	89	14	measurement	measurement	NOUN
bptjm-67	89	15	,	,	PUNCT
bptjm-67	89	16	typically	typically	ADV
bptjm-67	89	17	capturing	capture	VERB
bptjm-67	89	18	data	datum	NOUN
bptjm-67	89	19	only	only	ADV
bptjm-67	89	20	from	from	ADP
bptjm-67	89	21	the	the	DET
bptjm-67	89	22	frontal	frontal	ADJ
bptjm-67	89	23	cortex	cortex	NOUN
bptjm-67	89	24	and	and	CCONJ
bptjm-67	89	25	superficial	superficial	ADJ
bptjm-67	89	26	cortical	cortical	ADJ
bptjm-67	89	27	areas	area	NOUN
bptjm-67	89	28	.	.	PUNCT
bptjm-67	90	1	berkeley	berkeley	PROPN
bptjm-67	90	2	pharma	pharma	PROPN
bptjm-67	90	3	tech	tech	PROPN
bptjm-67	90	4	journal	journal	NOUN
bptjm-67	90	5	of	of	ADP
bptjm-67	90	6	medicine	medicine	NOUN
bptjm-67	90	7	|	|	ADV
bptjm-67	90	8	133	133	NUM
bptjm-67	90	9	figure	figure	NOUN
bptjm-67	90	10	8	8	NUM
bptjm-67	90	11	:	:	PUNCT
bptjm-67	90	12	functional	functional	ADJ
bptjm-67	90	13	near	near	ADV
bptjm-67	90	14	-	-	PUNCT
bptjm-67	90	15	infrared	infrared	ADJ
bptjm-67	90	16	spectroscopy	spectroscopy	NOUN
bptjm-67	90	17	.	.	PUNCT
bptjm-67	91	1	functional	functional	ADJ
bptjm-67	91	2	near	near	ADV
bptjm-67	91	3	-	-	PUNCT
bptjm-67	91	4	infrared	infrared	ADJ
bptjm-67	91	5	spectroscopy	spectroscopy	NOUN
bptjm-67	91	6	(	(	PUNCT
bptjm-67	91	7	fnirs	fnir	NOUN
bptjm-67	91	8	)	)	PUNCT
bptjm-67	91	9	is	be	AUX
bptjm-67	91	10	used	use	VERB
bptjm-67	91	11	for	for	ADP
bptjm-67	91	12	non	non	ADJ
bptjm-67	91	13	-	-	ADJ
bptjm-67	91	14	invasive	invasive	ADJ
bptjm-67	91	15	monitoring	monitoring	NOUN
bptjm-67	91	16	of	of	ADP
bptjm-67	91	17	changes	change	NOUN
bptjm-67	91	18	in	in	ADP
bptjm-67	91	19	oxyand	oxyand	NOUN
bptjm-67	91	20	deoxyhemoglobin	deoxyhemoglobin	ADJ
bptjm-67	91	21	levels	level	NOUN
bptjm-67	91	22	within	within	ADP
bptjm-67	91	23	the	the	DET
bptjm-67	91	24	brain	brain	NOUN
bptjm-67	91	25	.	.	PUNCT
bptjm-67	92	1	it	it	PRON
bptjm-67	92	2	involves	involve	VERB
bptjm-67	92	3	a	a	DET
bptjm-67	92	4	configuration	configuration	NOUN
bptjm-67	92	5	of	of	ADP
bptjm-67	92	6	fiber	fiber	NOUN
bptjm-67	92	7	optic	optic	NOUN
bptjm-67	92	8	-	-	PUNCT
bptjm-67	92	9	based	base	VERB
bptjm-67	92	10	light	light	NOUN
bptjm-67	92	11	sources	source	NOUN
bptjm-67	92	12	and	and	CCONJ
bptjm-67	92	13	detectors	detector	NOUN
bptjm-67	92	14	arranged	arrange	VERB
bptjm-67	92	15	on	on	ADP
bptjm-67	92	16	a	a	DET
bptjm-67	92	17	flexible	flexible	ADJ
bptjm-67	92	18	head	head	NOUN
bptjm-67	92	19	cap	cap	NOUN
bptjm-67	92	20	worn	wear	VERB
bptjm-67	92	21	by	by	ADP
bptjm-67	92	22	the	the	DET
bptjm-67	92	23	participant	participant	NOUN
bptjm-67	92	24	.	.	PUNCT
bptjm-67	93	1	4	4	X
bptjm-67	93	2	.	.	X
bptjm-67	93	3	neurovascular	neurovascular	ADJ
bptjm-67	93	4	coupling	couple	VERB
bptjm-67	93	5	targeted	target	VERB
bptjm-67	93	6	market	market	NOUN
bptjm-67	93	7	therapeutics	therapeutic	NOUN
bptjm-67	93	8	exploring	explore	VERB
bptjm-67	93	9	new	new	ADJ
bptjm-67	93	10	treatments	treatment	NOUN
bptjm-67	93	11	for	for	ADP
bptjm-67	93	12	brain	brain	NOUN
bptjm-67	93	13	health	health	NOUN
bptjm-67	93	14	is	be	AUX
bptjm-67	93	15	essential	essential	ADJ
bptjm-67	93	16	in	in	ADP
bptjm-67	93	17	addressing	address	VERB
bptjm-67	93	18	cognitive	cognitive	ADJ
bptjm-67	93	19	decline	decline	NOUN
bptjm-67	93	20	.	.	PUNCT
bptjm-67	94	1	this	this	DET
bptjm-67	94	2	article	article	NOUN
bptjm-67	94	3	introduces	introduce	VERB
bptjm-67	94	4	several	several	ADJ
bptjm-67	94	5	options	option	NOUN
bptjm-67	94	6	,	,	PUNCT
bptjm-67	94	7	including	include	VERB
bptjm-67	94	8	cocoa	cocoa	NOUN
bptjm-67	94	9	flavonoids	flavonoid	NOUN
bptjm-67	94	10	(	(	PUNCT
bptjm-67	94	11	cf	cf	NOUN
bptjm-67	94	12	)	)	PUNCT
bptjm-67	94	13	,	,	PUNCT
bptjm-67	94	14	nicotinamide	nicotinamide	NOUN
bptjm-67	94	15	mononucleotide(nmn	mononucleotide(nmn	NOUN
bptjm-67	94	16	)	)	PUNCT
bptjm-67	94	17	,	,	PUNCT
bptjm-67	94	18	i	i	PROPN
bptjm-67	94	19	-	-	PUNCT
bptjm-67	94	20	no	no	DET
bptjm-67	94	21	pericyte	pericyte	NOUN
bptjm-67	94	22	relaxant	relaxant	NOUN
bptjm-67	94	23	,	,	PUNCT
bptjm-67	94	24	inorganic	inorganic	ADJ
bptjm-67	94	25	nitrate	nitrate	NOUN
bptjm-67	94	26	supplementation	supplementation	NOUN
bptjm-67	94	27	,	,	PUNCT
bptjm-67	94	28	and	and	CCONJ
bptjm-67	94	29	nicotinamide	nicotinamide	NOUN
bptjm-67	94	30	adenine	adenine	ADJ
bptjm-67	94	31	dinucleotide	dinucleotide	NOUN
bptjm-67	94	32	(	(	PUNCT
bptjm-67	94	33	nad	nad	NOUN
bptjm-67	94	34	)	)	PUNCT
bptjm-67	94	35	supplementation	supplementation	NOUN
bptjm-67	94	36	.	.	PUNCT
bptjm-67	95	1	each	each	PRON
bptjm-67	95	2	offers	offer	VERB
bptjm-67	95	3	potential	potential	ADJ
bptjm-67	95	4	benefits	benefit	NOUN
bptjm-67	95	5	,	,	PUNCT
bptjm-67	95	6	but	but	CCONJ
bptjm-67	95	7	future	future	ADJ
bptjm-67	95	8	research	research	NOUN
bptjm-67	95	9	is	be	AUX
bptjm-67	95	10	required	require	VERB
bptjm-67	95	11	to	to	PART
bptjm-67	95	12	confirm	confirm	VERB
bptjm-67	95	13	their	their	PRON
bptjm-67	95	14	safety	safety	NOUN
bptjm-67	95	15	and	and	CCONJ
bptjm-67	95	16	effectiveness	effectiveness	NOUN
bptjm-67	95	17	.	.	PUNCT
bptjm-67	96	1	4.1	4.1	NUM
bptjm-67	96	2	cocoa	cocoa	NOUN
bptjm-67	96	3	flavonoids	flavonoid	NOUN
bptjm-67	96	4	(	(	PUNCT
bptjm-67	96	5	cf	cf	NOUN
bptjm-67	96	6	)	)	PUNCT
bptjm-67	96	7	cocoa	cocoa	NOUN
bptjm-67	96	8	flavonoids	flavonoid	NOUN
bptjm-67	96	9	(	(	PUNCT
bptjm-67	96	10	cf	cf	NOUN
bptjm-67	96	11	)	)	PUNCT
bptjm-67	96	12	are	be	AUX
bptjm-67	96	13	recognized	recognize	VERB
bptjm-67	96	14	for	for	ADP
bptjm-67	96	15	their	their	PRON
bptjm-67	96	16	neuroprotective	neuroprotective	ADJ
bptjm-67	96	17	attributes	attribute	NOUN
bptjm-67	96	18	,	,	PUNCT
bptjm-67	96	19	antioxidant	antioxidant	ADJ
bptjm-67	96	20	and	and	CCONJ
bptjm-67	96	21	vasodilatory	vasodilatory	NOUN
bptjm-67	96	22	properties	property	NOUN
bptjm-67	96	23	,	,	PUNCT
bptjm-67	96	24	and	and	CCONJ
bptjm-67	96	25	their	their	PRON
bptjm-67	96	26	ability	ability	NOUN
bptjm-67	96	27	to	to	PART
bptjm-67	96	28	inhibit	inhibit	VERB
bptjm-67	96	29	cholinesterase	cholinesterase	NOUN
bptjm-67	96	30	and	and	CCONJ
bptjm-67	96	31	tau	tau	PROPN
bptjm-67	96	32	formation	formation	NOUN
bptjm-67	96	33	.	.	PUNCT
bptjm-67	97	1	despite	despite	SCONJ
bptjm-67	97	2	these	these	DET
bptjm-67	97	3	promising	promising	ADJ
bptjm-67	97	4	attributes	attribute	NOUN
bptjm-67	97	5	,	,	PUNCT
bptjm-67	97	6	their	their	PRON
bptjm-67	97	7	effects	effect	NOUN
bptjm-67	97	8	appear	appear	VERB
bptjm-67	97	9	limited	limited	ADJ
bptjm-67	97	10	in	in	ADP
bptjm-67	97	11	scope	scope	NOUN
bptjm-67	97	12	.	.	PUNCT
bptjm-67	98	1	current	current	ADJ
bptjm-67	98	2	evidence	evidence	NOUN
bptjm-67	98	3	suggests	suggest	VERB
bptjm-67	98	4	that	that	SCONJ
bptjm-67	98	5	cf	cf	NOUN
bptjm-67	98	6	primarily	primarily	ADV
bptjm-67	98	7	increases	increase	VERB
bptjm-67	98	8	bold	bold	ADJ
bptjm-67	98	9	(	(	PUNCT
bptjm-67	98	10	blood	blood	NOUN
bptjm-67	98	11	-	-	PUNCT
bptjm-67	98	12	oxygen	oxygen	NOUN
bptjm-67	98	13	-	-	PUNCT
bptjm-67	98	14	level	level	NOUN
bptjm-67	98	15	-	-	PUNCT
bptjm-67	98	16	dependent	dependent	ADJ
bptjm-67	98	17	)	)	PUNCT
bptjm-67	98	18	responses	response	NOUN
bptjm-67	98	19	in	in	ADP
bptjm-67	98	20	specific	specific	ADJ
bptjm-67	98	21	brain	brain	NOUN
bptjm-67	98	22	regions	region	NOUN
bptjm-67	98	23	—	—	PUNCT
bptjm-67	98	24	namely	namely	ADV
bptjm-67	98	25	the	the	DET
bptjm-67	98	26	supramarginal	supramarginal	ADJ
bptjm-67	98	27	gyrus	gyrus	NOUN
bptjm-67	98	28	of	of	ADP
bptjm-67	98	29	the	the	DET
bptjm-67	98	30	parietal	parietal	ADJ
bptjm-67	98	31	lobe	lobe	NOUN
bptjm-67	98	32	and	and	CCONJ
bptjm-67	98	33	the	the	DET
bptjm-67	98	34	inferior	inferior	ADJ
bptjm-67	98	35	frontal	frontal	ADJ
bptjm-67	98	36	gyrus.21	gyrus.21	NOUN
bptjm-67	98	37	the	the	DET
bptjm-67	98	38	effects	effect	NOUN
bptjm-67	98	39	of	of	ADP
bptjm-67	98	40	cf	cf	NOUN
bptjm-67	98	41	intake	intake	NOUN
bptjm-67	98	42	are	be	AUX
bptjm-67	98	43	not	not	PART
bptjm-67	98	44	well	well	ADV
bptjm-67	98	45	understood	understand	VERB
bptjm-67	98	46	,	,	PUNCT
bptjm-67	98	47	and	and	CCONJ
bptjm-67	98	48	clinical	clinical	ADJ
bptjm-67	98	49	studies	study	NOUN
bptjm-67	98	50	are	be	AUX
bptjm-67	98	51	required	require	VERB
bptjm-67	98	52	to	to	PART
bptjm-67	98	53	further	far	ADV
bptjm-67	98	54	investigate	investigate	VERB
bptjm-67	98	55	their	their	PRON
bptjm-67	98	56	impact	impact	NOUN
bptjm-67	98	57	.	.	PUNCT
bptjm-67	99	1	berkeley	berkeley	PROPN
bptjm-67	99	2	pharma	pharma	PROPN
bptjm-67	99	3	tech	tech	PROPN
bptjm-67	99	4	journal	journal	NOUN
bptjm-67	99	5	of	of	ADP
bptjm-67	99	6	medicine	medicine	NOUN
bptjm-67	99	7	|	|	ADV
bptjm-67	99	8	134	134	NUM
bptjm-67	99	9	4.2	4.2	NUM
bptjm-67	99	10	nicotinamide	nicotinamide	NOUN
bptjm-67	99	11	mononucleotide	mononucleotide	NOUN
bptjm-67	99	12	(	(	PUNCT
bptjm-67	99	13	nmn	nmn	ADJ
bptjm-67	99	14	)	)	PUNCT
bptjm-67	99	15	nicotinamide	nicotinamide	NOUN
bptjm-67	99	16	mononucleotide	mononucleotide	NOUN
bptjm-67	99	17	(	(	PUNCT
bptjm-67	99	18	nmn	nmn	PROPN
bptjm-67	99	19	)	)	PUNCT
bptjm-67	99	20	is	be	AUX
bptjm-67	99	21	another	another	DET
bptjm-67	99	22	treatment	treatment	NOUN
bptjm-67	99	23	option	option	NOUN
bptjm-67	99	24	that	that	PRON
bptjm-67	99	25	enhances	enhance	VERB
bptjm-67	99	26	endothelial	endothelial	ADJ
bptjm-67	99	27	no	no	PRON
bptjm-67	99	28	-	-	PUNCT
bptjm-67	99	29	mediated	mediate	VERB
bptjm-67	99	30	vasodilation	vasodilation	NOUN
bptjm-67	99	31	and	and	CCONJ
bptjm-67	99	32	serves	serve	VERB
bptjm-67	99	33	as	as	ADP
bptjm-67	99	34	an	an	DET
bptjm-67	99	35	nad+	nad+	NOUN
bptjm-67	99	36	intermediate	intermediate	ADJ
bptjm-67	99	37	.	.	PUNCT
bptjm-67	100	1	it	it	PRON
bptjm-67	100	2	is	be	AUX
bptjm-67	100	3	also	also	ADV
bptjm-67	100	4	recognized	recognize	VERB
bptjm-67	100	5	for	for	ADP
bptjm-67	100	6	improving	improve	VERB
bptjm-67	100	7	spatial	spatial	ADJ
bptjm-67	100	8	working	work	VERB
bptjm-67	100	9	memory	memory	NOUN
bptjm-67	100	10	and	and	CCONJ
bptjm-67	100	11	movement	movement	NOUN
bptjm-67	100	12	coordination	coordination	NOUN
bptjm-67	100	13	.	.	PUNCT
bptjm-67	101	1	however	however	ADV
bptjm-67	101	2	,	,	PUNCT
bptjm-67	101	3	most	most	ADJ
bptjm-67	101	4	research	research	NOUN
bptjm-67	101	5	has	have	AUX
bptjm-67	101	6	focused	focus	VERB
bptjm-67	101	7	on	on	ADP
bptjm-67	101	8	its	its	PRON
bptjm-67	101	9	vascular	vascular	ADJ
bptjm-67	101	10	effects	effect	NOUN
bptjm-67	101	11	in	in	ADP
bptjm-67	101	12	large	large	ADJ
bptjm-67	101	13	arteries	artery	NOUN
bptjm-67	101	14	,	,	PUNCT
bptjm-67	101	15	such	such	ADJ
bptjm-67	101	16	as	as	ADP
bptjm-67	101	17	the	the	DET
bptjm-67	101	18	aorta	aorta	NOUN
bptjm-67	101	19	,	,	PUNCT
bptjm-67	101	20	leaving	leave	VERB
bptjm-67	101	21	its	its	PRON
bptjm-67	101	22	broader	broad	ADJ
bptjm-67	101	23	systemic	systemic	ADJ
bptjm-67	101	24	and	and	CCONJ
bptjm-67	101	25	neurological	neurological	ADJ
bptjm-67	101	26	interactions	interaction	NOUN
bptjm-67	101	27	underexplored	underexplored	ADJ
bptjm-67	101	28	.	.	PUNCT
bptjm-67	102	1	moreover	moreover	ADV
bptjm-67	102	2	,	,	PUNCT
bptjm-67	102	3	some	some	DET
bptjm-67	102	4	clinical	clinical	ADJ
bptjm-67	102	5	trials	trial	NOUN
bptjm-67	102	6	have	have	AUX
bptjm-67	102	7	reported	report	VERB
bptjm-67	102	8	adverse	adverse	ADJ
bptjm-67	102	9	effects	effect	NOUN
bptjm-67	102	10	,	,	PUNCT
bptjm-67	102	11	raising	raise	VERB
bptjm-67	102	12	concerns	concern	NOUN
bptjm-67	102	13	about	about	ADP
bptjm-67	102	14	the	the	DET
bptjm-67	102	15	safety	safety	NOUN
bptjm-67	102	16	and	and	CCONJ
bptjm-67	102	17	long	long	ADJ
bptjm-67	102	18	-	-	PUNCT
bptjm-67	102	19	term	term	NOUN
bptjm-67	102	20	efficacy	efficacy	NOUN
bptjm-67	102	21	of	of	ADP
bptjm-67	102	22	nad⁺	nad⁺	NOUN
bptjm-67	102	23	intermediates	intermediate	NOUN
bptjm-67	102	24	like	like	ADP
bptjm-67	102	25	nmn	nmn	PROPN
bptjm-67	102	26	.	.	PUNCT
bptjm-67	103	1	these	these	DET
bptjm-67	103	2	findings	finding	NOUN
bptjm-67	103	3	underscore	underscore	VERB
bptjm-67	103	4	the	the	DET
bptjm-67	103	5	need	need	NOUN
bptjm-67	103	6	for	for	ADP
bptjm-67	103	7	further	further	ADJ
bptjm-67	103	8	investigation	investigation	NOUN
bptjm-67	103	9	to	to	PART
bptjm-67	103	10	better	well	ADV
bptjm-67	103	11	understand	understand	VERB
bptjm-67	103	12	its	its	PRON
bptjm-67	103	13	therapeutic	therapeutic	ADJ
bptjm-67	103	14	viability.22	viability.22	NOUN
bptjm-67	103	15	4.3	4.3	NUM
bptjm-67	104	1	i	i	PROPN
bptjm-67	104	2	-	-	PUNCT
bptjm-67	104	3	no	no	DET
bptjm-67	104	4	pericyte	pericyte	NOUN
bptjm-67	104	5	relaxant	relaxant	NOUN
bptjm-67	104	6	i	i	PROPN
bptjm-67	104	7	-	-	PUNCT
bptjm-67	104	8	no	no	PRON
bptjm-67	104	9	pericyte	pericyte	NOUN
bptjm-67	104	10	relaxant	relaxant	NOUN
bptjm-67	104	11	demonstrates	demonstrate	VERB
bptjm-67	104	12	potential	potential	ADJ
bptjm-67	104	13	as	as	ADP
bptjm-67	104	14	treatment	treatment	NOUN
bptjm-67	104	15	by	by	ADP
bptjm-67	104	16	opening	open	VERB
bptjm-67	104	17	constricted	constrict	VERB
bptjm-67	104	18	blood	blood	NOUN
bptjm-67	104	19	vessels	vessel	NOUN
bptjm-67	104	20	,	,	PUNCT
bptjm-67	104	21	becoming	become	VERB
bptjm-67	104	22	neuroprotective	neuroprotective	ADJ
bptjm-67	104	23	in	in	ADP
bptjm-67	104	24	other	other	ADJ
bptjm-67	104	25	mammals	mammal	NOUN
bptjm-67	104	26	,	,	PUNCT
bptjm-67	104	27	and	and	CCONJ
bptjm-67	104	28	assisting	assist	VERB
bptjm-67	104	29	in	in	ADP
bptjm-67	104	30	recanalization	recanalization	NOUN
bptjm-67	104	31	and	and	CCONJ
bptjm-67	104	32	pretreatment	pretreatment	NOUN
bptjm-67	104	33	.	.	PUNCT
bptjm-67	105	1	while	while	SCONJ
bptjm-67	105	2	showing	show	VERB
bptjm-67	105	3	strength	strength	NOUN
bptjm-67	105	4	as	as	ADP
bptjm-67	105	5	a	a	DET
bptjm-67	105	6	neuroprotective	neuroprotective	ADJ
bptjm-67	105	7	agent	agent	NOUN
bptjm-67	105	8	and	and	CCONJ
bptjm-67	105	9	in	in	ADP
bptjm-67	105	10	aiding	aid	VERB
bptjm-67	105	11	blood	blood	NOUN
bptjm-67	105	12	flow	flow	NOUN
bptjm-67	105	13	,	,	PUNCT
bptjm-67	105	14	this	this	PRON
bptjm-67	105	15	presents	present	VERB
bptjm-67	105	16	certain	certain	ADJ
bptjm-67	105	17	challenges	challenge	NOUN
bptjm-67	105	18	.	.	PUNCT
bptjm-67	106	1	for	for	ADP
bptjm-67	106	2	example	example	NOUN
bptjm-67	106	3	,	,	PUNCT
bptjm-67	106	4	its	its	PRON
bptjm-67	106	5	efficacy	efficacy	NOUN
bptjm-67	106	6	can	can	AUX
bptjm-67	106	7	be	be	AUX
bptjm-67	106	8	compromised	compromise	VERB
bptjm-67	106	9	by	by	ADP
bptjm-67	106	10	interactions	interaction	NOUN
bptjm-67	106	11	with	with	ADP
bptjm-67	106	12	other	other	ADJ
bptjm-67	106	13	chemicals	chemical	NOUN
bptjm-67	106	14	such	such	ADJ
bptjm-67	106	15	as	as	ADP
bptjm-67	106	16	adenosine	adenosine	ADJ
bptjm-67	106	17	triphosphate	triphosphate	NOUN
bptjm-67	106	18	,	,	PUNCT
bptjm-67	106	19	norepinephrine	norepinephrine	NOUN
bptjm-67	106	20	,	,	PUNCT
bptjm-67	106	21	angiotensin	angiotensin	NOUN
bptjm-67	106	22	ii	ii	PROPN
bptjm-67	106	23	,	,	PUNCT
bptjm-67	106	24	and	and	CCONJ
bptjm-67	106	25	intracellular	intracellular	ADJ
bptjm-67	106	26	reactive	reactive	ADJ
bptjm-67	106	27	oxygen	oxygen	NOUN
bptjm-67	106	28	species	specie	NOUN
bptjm-67	106	29	.	.	PUNCT
bptjm-67	107	1	these	these	DET
bptjm-67	107	2	chemicals	chemical	NOUN
bptjm-67	107	3	can	can	AUX
bptjm-67	107	4	potentially	potentially	ADV
bptjm-67	107	5	reduce	reduce	VERB
bptjm-67	107	6	its	its	PRON
bptjm-67	107	7	therapeutic	therapeutic	ADJ
bptjm-67	107	8	benefits	benefit	NOUN
bptjm-67	107	9	.	.	PUNCT
bptjm-67	108	1	additionally	additionally	ADV
bptjm-67	108	2	,	,	PUNCT
bptjm-67	108	3	there	there	PRON
bptjm-67	108	4	are	be	VERB
bptjm-67	108	5	reported	report	VERB
bptjm-67	108	6	side	side	NOUN
bptjm-67	108	7	effects	effect	NOUN
bptjm-67	108	8	that	that	PRON
bptjm-67	108	9	could	could	AUX
bptjm-67	108	10	be	be	AUX
bptjm-67	108	11	detrimental	detrimental	ADJ
bptjm-67	108	12	to	to	ADP
bptjm-67	108	13	patients	patient	NOUN
bptjm-67	108	14	.	.	PUNCT
bptjm-67	109	1	given	give	VERB
bptjm-67	109	2	these	these	DET
bptjm-67	109	3	issues	issue	NOUN
bptjm-67	109	4	,	,	PUNCT
bptjm-67	109	5	it	it	PRON
bptjm-67	109	6	is	be	AUX
bptjm-67	109	7	clear	clear	ADJ
bptjm-67	109	8	that	that	SCONJ
bptjm-67	109	9	extensive	extensive	ADJ
bptjm-67	109	10	human	human	ADJ
bptjm-67	109	11	clinical	clinical	ADJ
bptjm-67	109	12	trials	trial	NOUN
bptjm-67	109	13	are	be	AUX
bptjm-67	109	14	required	require	VERB
bptjm-67	109	15	to	to	PART
bptjm-67	109	16	verify	verify	VERB
bptjm-67	109	17	the	the	DET
bptjm-67	109	18	treatment	treatment	NOUN
bptjm-67	109	19	's	's	PART
bptjm-67	109	20	safety	safety	NOUN
bptjm-67	109	21	and	and	CCONJ
bptjm-67	109	22	to	to	PART
bptjm-67	109	23	ensure	ensure	VERB
bptjm-67	109	24	its	its	PRON
bptjm-67	109	25	therapeutic	therapeutic	ADJ
bptjm-67	109	26	efficacy	efficacy	NOUN
bptjm-67	109	27	is	be	AUX
bptjm-67	109	28	consistent	consistent	ADJ
bptjm-67	109	29	and	and	CCONJ
bptjm-67	109	30	reliable	reliable	ADJ
bptjm-67	109	31	.	.	PUNCT
bptjm-67	110	1	4.4	4.4	NUM
bptjm-67	110	2	inorganic	inorganic	ADJ
bptjm-67	110	3	nitrate	nitrate	NOUN
bptjm-67	110	4	supplementation	supplementation	NOUN
bptjm-67	110	5	inorganic	inorganic	ADJ
bptjm-67	110	6	nitrate	nitrate	NOUN
bptjm-67	110	7	supplementation	supplementation	NOUN
bptjm-67	110	8	is	be	AUX
bptjm-67	110	9	a	a	DET
bptjm-67	110	10	non	non	ADJ
bptjm-67	110	11	-	-	ADJ
bptjm-67	110	12	pharmaceutical	pharmaceutical	ADJ
bptjm-67	110	13	approach	approach	NOUN
bptjm-67	110	14	used	use	VERB
bptjm-67	110	15	to	to	PART
bptjm-67	110	16	support	support	VERB
bptjm-67	110	17	cerebral	cerebral	ADJ
bptjm-67	110	18	vascular	vascular	ADJ
bptjm-67	110	19	health	health	NOUN
bptjm-67	110	20	.	.	PUNCT
bptjm-67	111	1	it	it	PRON
bptjm-67	111	2	is	be	AUX
bptjm-67	111	3	available	available	ADJ
bptjm-67	111	4	over	over	ADP
bptjm-67	111	5	the	the	DET
bptjm-67	111	6	counter	counter	NOUN
bptjm-67	111	7	in	in	ADP
bptjm-67	111	8	supplement	supplement	NOUN
bptjm-67	111	9	form	form	NOUN
bptjm-67	111	10	and	and	CCONJ
bptjm-67	111	11	naturally	naturally	ADV
bptjm-67	111	12	occurs	occur	VERB
bptjm-67	111	13	in	in	ADP
bptjm-67	111	14	dietary	dietary	ADJ
bptjm-67	111	15	sources	source	NOUN
bptjm-67	111	16	such	such	ADJ
bptjm-67	111	17	as	as	ADP
bptjm-67	111	18	beetroot	beetroot	NOUN
bptjm-67	111	19	juice	juice	NOUN
bptjm-67	111	20	.	.	PUNCT
bptjm-67	112	1	inorganic	inorganic	ADJ
bptjm-67	112	2	nitrates	nitrate	NOUN
bptjm-67	112	3	are	be	AUX
bptjm-67	112	4	known	know	VERB
bptjm-67	112	5	to	to	PART
bptjm-67	112	6	reduce	reduce	VERB
bptjm-67	112	7	blood	blood	NOUN
bptjm-67	112	8	pressure	pressure	NOUN
bptjm-67	112	9	,	,	PUNCT
bptjm-67	112	10	enhance	enhance	VERB
bptjm-67	112	11	endothelial	endothelial	ADJ
bptjm-67	112	12	function	function	NOUN
bptjm-67	112	13	,	,	PUNCT
bptjm-67	112	14	and	and	CCONJ
bptjm-67	112	15	potentially	potentially	ADV
bptjm-67	112	16	improve	improve	VERB
bptjm-67	112	17	athletic	athletic	ADJ
bptjm-67	112	18	performance	performance	NOUN
bptjm-67	112	19	.	.	PUNCT
bptjm-67	113	1	while	while	SCONJ
bptjm-67	113	2	generally	generally	ADV
bptjm-67	113	3	well	well	ADV
bptjm-67	113	4	-	-	PUNCT
bptjm-67	113	5	tolerated	tolerate	VERB
bptjm-67	113	6	and	and	CCONJ
bptjm-67	113	7	being	be	AUX
bptjm-67	113	8	a	a	DET
bptjm-67	113	9	non	non	ADJ
bptjm-67	113	10	-	-	ADJ
bptjm-67	113	11	pharmaceutical	pharmaceutical	ADJ
bptjm-67	113	12	option	option	NOUN
bptjm-67	113	13	,	,	PUNCT
bptjm-67	113	14	some	some	DET
bptjm-67	113	15	individuals	individual	NOUN
bptjm-67	113	16	may	may	AUX
bptjm-67	113	17	experience	experience	VERB
bptjm-67	113	18	side	side	NOUN
bptjm-67	113	19	effects	effect	NOUN
bptjm-67	113	20	such	such	ADJ
bptjm-67	113	21	as	as	ADP
bptjm-67	113	22	stomach	stomach	NOUN
bptjm-67	113	23	discomfort	discomfort	NOUN
bptjm-67	113	24	,	,	PUNCT
bptjm-67	113	25	changes	change	VERB
bptjm-67	113	26	berkeley	berkeley	PROPN
bptjm-67	113	27	pharma	pharma	PROPN
bptjm-67	113	28	tech	tech	NOUN
bptjm-67	113	29	journal	journal	NOUN
bptjm-67	113	30	of	of	ADP
bptjm-67	113	31	medicine	medicine	NOUN
bptjm-67	113	32	|	|	ADV
bptjm-67	113	33	135	135	NUM
bptjm-67	113	34	in	in	ADP
bptjm-67	113	35	bowel	bowel	NOUN
bptjm-67	113	36	movements	movement	NOUN
bptjm-67	113	37	,	,	PUNCT
bptjm-67	113	38	or	or	CCONJ
bptjm-67	113	39	colored	colored	ADJ
bptjm-67	113	40	urine	urine	NOUN
bptjm-67	113	41	.	.	PUNCT
bptjm-67	114	1	a	a	DET
bptjm-67	114	2	notable	notable	ADJ
bptjm-67	114	3	concern	concern	NOUN
bptjm-67	114	4	is	be	AUX
bptjm-67	114	5	the	the	DET
bptjm-67	114	6	potential	potential	NOUN
bptjm-67	114	7	for	for	ADP
bptjm-67	114	8	drug	drug	NOUN
bptjm-67	114	9	interactions	interaction	NOUN
bptjm-67	114	10	,	,	PUNCT
bptjm-67	114	11	particularly	particularly	ADV
bptjm-67	114	12	with	with	ADP
bptjm-67	114	13	medications	medication	NOUN
bptjm-67	114	14	that	that	PRON
bptjm-67	114	15	affect	affect	VERB
bptjm-67	114	16	nitric	nitric	ADJ
bptjm-67	114	17	oxide	oxide	NOUN
bptjm-67	114	18	pathways	pathway	NOUN
bptjm-67	114	19	,	,	PUNCT
bptjm-67	114	20	which	which	PRON
bptjm-67	114	21	may	may	AUX
bptjm-67	114	22	increase	increase	VERB
bptjm-67	114	23	the	the	DET
bptjm-67	114	24	risk	risk	NOUN
bptjm-67	114	25	of	of	ADP
bptjm-67	114	26	conditions	condition	NOUN
bptjm-67	114	27	like	like	ADP
bptjm-67	114	28	methemoglobinemia	methemoglobinemia	NOUN
bptjm-67	114	29	.	.	PUNCT
bptjm-67	115	1	despite	despite	SCONJ
bptjm-67	115	2	its	its	PRON
bptjm-67	115	3	benefits	benefit	NOUN
bptjm-67	115	4	,	,	PUNCT
bptjm-67	115	5	the	the	DET
bptjm-67	115	6	long	long	ADJ
bptjm-67	115	7	-	-	PUNCT
bptjm-67	115	8	term	term	NOUN
bptjm-67	115	9	effects	effect	NOUN
bptjm-67	115	10	of	of	ADP
bptjm-67	115	11	inorganic	inorganic	ADJ
bptjm-67	115	12	nitrate	nitrate	NOUN
bptjm-67	115	13	supplementation	supplementation	NOUN
bptjm-67	115	14	remain	remain	VERB
bptjm-67	115	15	unclear	unclear	ADJ
bptjm-67	115	16	.	.	PUNCT
bptjm-67	116	1	further	further	ADJ
bptjm-67	116	2	research	research	NOUN
bptjm-67	116	3	is	be	AUX
bptjm-67	116	4	necessary	necessary	ADJ
bptjm-67	116	5	to	to	PART
bptjm-67	116	6	fully	fully	ADV
bptjm-67	116	7	understand	understand	VERB
bptjm-67	116	8	its	its	PRON
bptjm-67	116	9	efficacy	efficacy	NOUN
bptjm-67	116	10	and	and	CCONJ
bptjm-67	116	11	safety	safety	NOUN
bptjm-67	116	12	for	for	ADP
bptjm-67	116	13	prolonged	prolonged	ADJ
bptjm-67	116	14	use	use	NOUN
bptjm-67	116	15	.	.	PUNCT
bptjm-67	117	1	4.5	4.5	NUM
bptjm-67	117	2	nicotinamide	nicotinamide	NOUN
bptjm-67	117	3	adenine	adenine	ADJ
bptjm-67	117	4	dinucleotide	dinucleotide	NOUN
bptjm-67	117	5	(	(	PUNCT
bptjm-67	117	6	nad	nad	NOUN
bptjm-67	117	7	)	)	PUNCT
bptjm-67	117	8	supplementation	supplementation	NOUN
bptjm-67	117	9	nicotinamide	nicotinamide	NOUN
bptjm-67	117	10	adenine	adenine	ADJ
bptjm-67	117	11	dinucleotide	dinucleotide	NOUN
bptjm-67	117	12	(	(	PUNCT
bptjm-67	117	13	nad	nad	NOUN
bptjm-67	117	14	)	)	PUNCT
bptjm-67	117	15	supplementation	supplementation	NOUN
bptjm-67	117	16	has	have	AUX
bptjm-67	117	17	emerged	emerge	VERB
bptjm-67	117	18	as	as	ADP
bptjm-67	117	19	a	a	DET
bptjm-67	117	20	promising	promising	ADJ
bptjm-67	117	21	strategy	strategy	NOUN
bptjm-67	117	22	to	to	PART
bptjm-67	117	23	mitigate	mitigate	VERB
bptjm-67	117	24	age	age	NOUN
bptjm-67	117	25	-	-	PUNCT
bptjm-67	117	26	related	relate	VERB
bptjm-67	117	27	cognitive	cognitive	ADJ
bptjm-67	117	28	decline	decline	NOUN
bptjm-67	117	29	.	.	PUNCT
bptjm-67	118	1	nad	nad	PROPN
bptjm-67	118	2	is	be	AUX
bptjm-67	118	3	a	a	DET
bptjm-67	118	4	coenzyme	coenzyme	NOUN
bptjm-67	118	5	essential	essential	ADJ
bptjm-67	118	6	for	for	ADP
bptjm-67	118	7	cellular	cellular	ADJ
bptjm-67	118	8	metabolism	metabolism	NOUN
bptjm-67	118	9	and	and	CCONJ
bptjm-67	118	10	energy	energy	NOUN
bptjm-67	118	11	production	production	NOUN
bptjm-67	118	12	,	,	PUNCT
bptjm-67	118	13	but	but	CCONJ
bptjm-67	118	14	its	its	PRON
bptjm-67	118	15	levels	level	NOUN
bptjm-67	118	16	naturally	naturally	ADV
bptjm-67	118	17	decline	decline	VERB
bptjm-67	118	18	with	with	ADP
bptjm-67	118	19	age	age	NOUN
bptjm-67	118	20	,	,	PUNCT
bptjm-67	118	21	which	which	PRON
bptjm-67	118	22	may	may	AUX
bptjm-67	118	23	contribute	contribute	VERB
bptjm-67	118	24	to	to	ADP
bptjm-67	118	25	reduced	reduce	VERB
bptjm-67	118	26	brain	brain	NOUN
bptjm-67	118	27	function	function	NOUN
bptjm-67	118	28	and	and	CCONJ
bptjm-67	118	29	vascular	vascular	ADJ
bptjm-67	118	30	integrity	integrity	NOUN
bptjm-67	118	31	.	.	PUNCT
bptjm-67	119	1	supplementation	supplementation	NOUN
bptjm-67	119	2	typically	typically	ADV
bptjm-67	119	3	involves	involve	VERB
bptjm-67	119	4	the	the	DET
bptjm-67	119	5	use	use	NOUN
bptjm-67	119	6	of	of	ADP
bptjm-67	119	7	nad	nad	ADJ
bptjm-67	119	8	precursors	precursor	NOUN
bptjm-67	119	9	,	,	PUNCT
bptjm-67	119	10	such	such	ADJ
bptjm-67	119	11	as	as	ADP
bptjm-67	119	12	nicotinamide	nicotinamide	NOUN
bptjm-67	119	13	riboside	riboside	NOUN
bptjm-67	119	14	(	(	PUNCT
bptjm-67	119	15	nr	nr	NOUN
bptjm-67	119	16	)	)	PUNCT
bptjm-67	119	17	and	and	CCONJ
bptjm-67	119	18	nicotinamide	nicotinamide	NOUN
bptjm-67	119	19	mononucleotide	mononucleotide	NOUN
bptjm-67	119	20	(	(	PUNCT
bptjm-67	119	21	nmn	nmn	PROPN
bptjm-67	119	22	)	)	PUNCT
bptjm-67	119	23	,	,	PUNCT
bptjm-67	119	24	which	which	PRON
bptjm-67	119	25	are	be	AUX
bptjm-67	119	26	intended	intend	VERB
bptjm-67	119	27	to	to	PART
bptjm-67	119	28	boost	boost	VERB
bptjm-67	119	29	intracellular	intracellular	ADJ
bptjm-67	119	30	nad⁺	nad⁺	NOUN
bptjm-67	119	31	levels	level	NOUN
bptjm-67	119	32	.	.	PUNCT
bptjm-67	120	1	this	this	PRON
bptjm-67	120	2	,	,	PUNCT
bptjm-67	120	3	in	in	ADP
bptjm-67	120	4	turn	turn	NOUN
bptjm-67	120	5	,	,	PUNCT
bptjm-67	120	6	may	may	AUX
bptjm-67	120	7	enhance	enhance	VERB
bptjm-67	120	8	mitochondrial	mitochondrial	ADJ
bptjm-67	120	9	function	function	NOUN
bptjm-67	120	10	and	and	CCONJ
bptjm-67	120	11	promote	promote	VERB
bptjm-67	120	12	neurovascular	neurovascular	ADJ
bptjm-67	120	13	health	health	NOUN
bptjm-67	120	14	.	.	PUNCT
bptjm-67	121	1	however	however	ADV
bptjm-67	121	2	,	,	PUNCT
bptjm-67	121	3	side	side	ADJ
bptjm-67	121	4	effects	effect	NOUN
bptjm-67	121	5	such	such	ADJ
bptjm-67	121	6	as	as	ADP
bptjm-67	121	7	nausea	nausea	NOUN
bptjm-67	121	8	,	,	PUNCT
bptjm-67	121	9	fatigue	fatigue	NOUN
bptjm-67	121	10	,	,	PUNCT
bptjm-67	121	11	headaches	headache	NOUN
bptjm-67	121	12	,	,	PUNCT
bptjm-67	121	13	and	and	CCONJ
bptjm-67	121	14	diarrhea	diarrhea	NOUN
bptjm-67	121	15	have	have	AUX
bptjm-67	121	16	been	be	AUX
bptjm-67	121	17	reported	report	VERB
bptjm-67	121	18	.	.	PUNCT
bptjm-67	122	1	although	although	SCONJ
bptjm-67	122	2	these	these	DET
bptjm-67	122	3	supplements	supplement	NOUN
bptjm-67	122	4	are	be	AUX
bptjm-67	122	5	generally	generally	ADV
bptjm-67	122	6	considered	consider	VERB
bptjm-67	122	7	safe	safe	ADJ
bptjm-67	122	8	at	at	ADP
bptjm-67	122	9	recommended	recommend	VERB
bptjm-67	122	10	doses	dose	NOUN
bptjm-67	122	11	,	,	PUNCT
bptjm-67	122	12	the	the	DET
bptjm-67	122	13	long	long	ADJ
bptjm-67	122	14	-	-	PUNCT
bptjm-67	122	15	term	term	NOUN
bptjm-67	122	16	effects	effect	NOUN
bptjm-67	122	17	remain	remain	VERB
bptjm-67	122	18	uncertain	uncertain	ADJ
bptjm-67	122	19	.	.	PUNCT
bptjm-67	123	1	further	further	ADJ
bptjm-67	123	2	clinical	clinical	ADJ
bptjm-67	123	3	trials	trial	NOUN
bptjm-67	123	4	are	be	AUX
bptjm-67	123	5	needed	need	VERB
bptjm-67	123	6	to	to	PART
bptjm-67	123	7	evaluate	evaluate	VERB
bptjm-67	123	8	the	the	DET
bptjm-67	123	9	full	full	ADJ
bptjm-67	123	10	therapeutic	therapeutic	ADJ
bptjm-67	123	11	potential	potential	NOUN
bptjm-67	123	12	and	and	CCONJ
bptjm-67	123	13	safety	safety	NOUN
bptjm-67	123	14	profile	profile	NOUN
bptjm-67	123	15	of	of	ADP
bptjm-67	123	16	nad	nad	ADJ
bptjm-67	123	17	supplementation	supplementation	NOUN
bptjm-67	123	18	for	for	ADP
bptjm-67	123	19	cognitive	cognitive	ADJ
bptjm-67	123	20	health	health	NOUN
bptjm-67	123	21	.	.	PUNCT
bptjm-67	124	1	currently	currently	ADV
bptjm-67	124	2	,	,	PUNCT
bptjm-67	124	3	researchers	researcher	NOUN
bptjm-67	124	4	are	be	AUX
bptjm-67	124	5	conducting	conduct	VERB
bptjm-67	124	6	two	two	NUM
bptjm-67	124	7	ongoing	ongoing	ADJ
bptjm-67	124	8	significant	significant	ADJ
bptjm-67	124	9	clinical	clinical	ADJ
bptjm-67	124	10	trials	trial	NOUN
bptjm-67	124	11	,	,	PUNCT
bptjm-67	124	12	nct03617302	nct03617302	NOUN
bptjm-67	124	13	and	and	CCONJ
bptjm-67	124	14	nct05483465	nct05483465	ADJ
bptjm-67	124	15	,	,	PUNCT
bptjm-67	124	16	related	relate	VERB
bptjm-67	124	17	to	to	ADP
bptjm-67	124	18	the	the	DET
bptjm-67	124	19	neurovascular	neurovascular	ADJ
bptjm-67	124	20	coupling	coupling	NOUN
bptjm-67	124	21	in	in	ADP
bptjm-67	124	22	cognitive	cognitive	ADJ
bptjm-67	124	23	decline	decline	NOUN
bptjm-67	124	24	.	.	PUNCT
bptjm-67	125	1	these	these	DET
bptjm-67	125	2	studies	study	NOUN
bptjm-67	125	3	aim	aim	VERB
bptjm-67	125	4	to	to	PART
bptjm-67	125	5	understand	understand	VERB
bptjm-67	125	6	how	how	SCONJ
bptjm-67	125	7	changes	change	NOUN
bptjm-67	125	8	in	in	ADP
bptjm-67	125	9	the	the	DET
bptjm-67	125	10	interaction	interaction	NOUN
bptjm-67	125	11	between	between	ADP
bptjm-67	125	12	neuronal	neuronal	ADJ
bptjm-67	125	13	activity	activity	NOUN
bptjm-67	125	14	and	and	CCONJ
bptjm-67	125	15	cerebral	cerebral	ADJ
bptjm-67	125	16	blood	blood	NOUN
bptjm-67	125	17	flow	flow	NOUN
bptjm-67	125	18	contribute	contribute	VERB
bptjm-67	125	19	to	to	ADP
bptjm-67	125	20	cognitive	cognitive	ADJ
bptjm-67	125	21	impairments	impairment	NOUN
bptjm-67	125	22	associated	associate	VERB
bptjm-67	125	23	with	with	ADP
bptjm-67	125	24	aging	aging	NOUN
bptjm-67	125	25	.	.	PUNCT
bptjm-67	126	1	by	by	ADP
bptjm-67	126	2	investigating	investigate	VERB
bptjm-67	126	3	different	different	ADJ
bptjm-67	126	4	interventions	intervention	NOUN
bptjm-67	126	5	,	,	PUNCT
bptjm-67	126	6	these	these	DET
bptjm-67	126	7	studies	study	NOUN
bptjm-67	126	8	aim	aim	VERB
bptjm-67	126	9	to	to	PART
bptjm-67	126	10	identify	identify	VERB
bptjm-67	126	11	interventions	intervention	NOUN
bptjm-67	126	12	that	that	PRON
bptjm-67	126	13	may	may	AUX
bptjm-67	126	14	slow	slow	VERB
bptjm-67	126	15	or	or	CCONJ
bptjm-67	126	16	mitigate	mitigate	VERB
bptjm-67	126	17	cognitive	cognitive	ADJ
bptjm-67	126	18	decline	decline	NOUN
bptjm-67	126	19	in	in	ADP
bptjm-67	126	20	older	old	ADJ
bptjm-67	126	21	adults	adult	NOUN
bptjm-67	126	22	.	.	PUNCT
bptjm-67	127	1	4.6	4.6	NUM
bptjm-67	127	2	inorganic	inorganic	ADJ
bptjm-67	127	3	nitrate	nitrate	NOUN
bptjm-67	127	4	supplementation	supplementation	NOUN
bptjm-67	127	5	on	on	ADP
bptjm-67	127	6	cerebrovascular	cerebrovascular	ADJ
bptjm-67	127	7	aging	aging	NOUN
bptjm-67	127	8	and	and	CCONJ
bptjm-67	127	9	arterial	arterial	ADJ
bptjm-67	127	10	stiffness	stiffness	NOUN
bptjm-67	127	11	the	the	DET
bptjm-67	127	12	first	first	ADJ
bptjm-67	127	13	ongoing	ongoing	ADJ
bptjm-67	127	14	clinical	clinical	ADJ
bptjm-67	127	15	study	study	NOUN
bptjm-67	127	16	"	"	PUNCT
bptjm-67	127	17	inorganic	inorganic	ADJ
bptjm-67	127	18	nitrate	nitrate	NOUN
bptjm-67	127	19	supplementation	supplementation	NOUN
bptjm-67	127	20	on	on	ADP
bptjm-67	127	21	cerebrovascular	cerebrovascular	ADJ
bptjm-67	127	22	aging	aging	NOUN
bptjm-67	127	23	and	and	CCONJ
bptjm-67	127	24	arterial	arterial	ADJ
bptjm-67	127	25	stiffness	stiffness	NOUN
bptjm-67	127	26	"	"	PUNCT
bptjm-67	127	27	focuses	focus	VERB
bptjm-67	127	28	on	on	ADP
bptjm-67	127	29	examining	examine	VERB
bptjm-67	127	30	the	the	DET
bptjm-67	127	31	effects	effect	NOUN
bptjm-67	127	32	of	of	ADP
bptjm-67	127	33	inorganic	inorganic	ADJ
bptjm-67	127	34	nitrate	nitrate	NOUN
bptjm-67	127	35	supplementation	supplementation	NOUN
bptjm-67	127	36	,	,	PUNCT
bptjm-67	127	37	particularly	particularly	ADV
bptjm-67	127	38	from	from	ADP
bptjm-67	127	39	beetroot	beetroot	PROPN
bptjm-67	127	40	berkeley	berkeley	PROPN
bptjm-67	127	41	pharma	pharma	PROPN
bptjm-67	127	42	tech	tech	NOUN
bptjm-67	127	43	journal	journal	NOUN
bptjm-67	127	44	of	of	ADP
bptjm-67	127	45	medicine	medicine	NOUN
bptjm-67	127	46	|	|	ADV
bptjm-67	127	47	136	136	NUM
bptjm-67	127	48	juice	juice	NOUN
bptjm-67	127	49	,	,	PUNCT
bptjm-67	127	50	on	on	ADP
bptjm-67	127	51	aging	age	VERB
bptjm-67	127	52	cerebrovascular	cerebrovascular	ADJ
bptjm-67	127	53	systems	system	NOUN
bptjm-67	127	54	and	and	CCONJ
bptjm-67	127	55	arterial	arterial	NOUN
bptjm-67	127	56	stiffness.23	stiffness.23	PROPN
bptjm-67	127	57	launched	launch	VERB
bptjm-67	127	58	on	on	ADP
bptjm-67	127	59	november	november	PROPN
bptjm-67	127	60	1	1	NUM
bptjm-67	127	61	,	,	PUNCT
bptjm-67	127	62	2018	2018	NUM
bptjm-67	127	63	,	,	PUNCT
bptjm-67	127	64	the	the	DET
bptjm-67	127	65	study	study	NOUN
bptjm-67	127	66	is	be	AUX
bptjm-67	127	67	expected	expect	VERB
bptjm-67	127	68	to	to	PART
bptjm-67	127	69	conclude	conclude	VERB
bptjm-67	127	70	on	on	ADP
bptjm-67	127	71	june	june	PROPN
bptjm-67	127	72	30	30	NUM
bptjm-67	127	73	,	,	PUNCT
bptjm-67	127	74	2024	2024	NUM
bptjm-67	127	75	.	.	PUNCT
bptjm-67	128	1	this	this	PRON
bptjm-67	128	2	randomized	randomize	VERB
bptjm-67	128	3	,	,	PUNCT
bptjm-67	128	4	double	double	ADJ
bptjm-67	128	5	-	-	PUNCT
bptjm-67	128	6	blind	blind	ADJ
bptjm-67	128	7	,	,	PUNCT
bptjm-67	128	8	crossover	crossover	NOUN
bptjm-67	128	9	study	study	NOUN
bptjm-67	128	10	enrolled	enrol	VERB
bptjm-67	128	11	53	53	NUM
bptjm-67	128	12	community	community	NOUN
bptjm-67	128	13	-	-	PUNCT
bptjm-67	128	14	dwelling	dwell	VERB
bptjm-67	128	15	older	old	ADJ
bptjm-67	128	16	adults	adult	NOUN
bptjm-67	128	17	,	,	PUNCT
bptjm-67	128	18	randomly	randomly	ADV
bptjm-67	128	19	assigned	assign	VERB
bptjm-67	128	20	to	to	ADP
bptjm-67	128	21	either	either	CCONJ
bptjm-67	128	22	an	an	DET
bptjm-67	128	23	experimental	experimental	ADJ
bptjm-67	128	24	or	or	CCONJ
bptjm-67	128	25	control	control	NOUN
bptjm-67	128	26	group	group	NOUN
bptjm-67	128	27	.	.	PUNCT
bptjm-67	129	1	the	the	DET
bptjm-67	129	2	experimental	experimental	ADJ
bptjm-67	129	3	group	group	NOUN
bptjm-67	129	4	received	receive	VERB
bptjm-67	129	5	nitrate	nitrate	NOUN
bptjm-67	129	6	-	-	PUNCT
bptjm-67	129	7	rich	rich	ADJ
bptjm-67	129	8	beetroot	beetroot	NOUN
bptjm-67	129	9	juice	juice	NOUN
bptjm-67	129	10	,	,	PUNCT
bptjm-67	129	11	while	while	SCONJ
bptjm-67	129	12	the	the	DET
bptjm-67	129	13	control	control	PROPN
bptjm-67	129	14	group	group	NOUN
bptjm-67	129	15	consumed	consume	VERB
bptjm-67	129	16	nitrate	nitrate	NOUN
bptjm-67	129	17	-	-	PUNCT
bptjm-67	129	18	depleted	deplete	VERB
bptjm-67	129	19	beetroot	beetroot	NOUN
bptjm-67	129	20	juice	juice	NOUN
bptjm-67	129	21	.	.	PUNCT
bptjm-67	130	1	the	the	DET
bptjm-67	130	2	primary	primary	ADJ
bptjm-67	130	3	outcomes	outcome	NOUN
bptjm-67	130	4	measured	measure	VERB
bptjm-67	130	5	were	be	AUX
bptjm-67	130	6	the	the	DET
bptjm-67	130	7	acute	acute	ADJ
bptjm-67	130	8	changes	change	NOUN
bptjm-67	130	9	in	in	ADP
bptjm-67	130	10	carotid	carotid	NOUN
bptjm-67	130	11	artery	artery	NOUN
bptjm-67	130	12	stiffness	stiffness	NOUN
bptjm-67	130	13	,	,	PUNCT
bptjm-67	130	14	assessed	assess	VERB
bptjm-67	130	15	through	through	ADP
bptjm-67	130	16	ultrasonography	ultrasonography	NOUN
bptjm-67	130	17	and	and	CCONJ
bptjm-67	130	18	applanation	applanation	NOUN
bptjm-67	130	19	tonometry	tonometry	NOUN
bptjm-67	130	20	,	,	PUNCT
bptjm-67	130	21	and	and	CCONJ
bptjm-67	130	22	changes	change	NOUN
bptjm-67	130	23	in	in	ADP
bptjm-67	130	24	cerebral	cerebral	ADJ
bptjm-67	130	25	blood	blood	NOUN
bptjm-67	130	26	flow	flow	NOUN
bptjm-67	130	27	which	which	PRON
bptjm-67	130	28	were	be	AUX
bptjm-67	130	29	measured	measure	VERB
bptjm-67	130	30	using	use	VERB
bptjm-67	130	31	4d	4d	NUM
bptjm-67	130	32	pc	pc	NOUN
bptjm-67	130	33	vipr	vipr	NOUN
bptjm-67	130	34	mri	mri	NOUN
bptjm-67	130	35	technology	technology	NOUN
bptjm-67	130	36	.	.	PUNCT
bptjm-67	131	1	the	the	DET
bptjm-67	131	2	4d	4d	NUM
bptjm-67	131	3	pc	pc	NOUN
bptjm-67	131	4	vipr	vipr	NOUN
bptjm-67	131	5	mri	mri	NOUN
bptjm-67	131	6	is	be	AUX
bptjm-67	131	7	an	an	DET
bptjm-67	131	8	advanced	advanced	ADJ
bptjm-67	131	9	imaging	imaging	NOUN
bptjm-67	131	10	technique	technique	NOUN
bptjm-67	131	11	that	that	PRON
bptjm-67	131	12	generates	generate	VERB
bptjm-67	131	13	detailed	detailed	ADJ
bptjm-67	131	14	,	,	PUNCT
bptjm-67	131	15	dynamic	dynamic	ADJ
bptjm-67	131	16	images	image	NOUN
bptjm-67	131	17	of	of	ADP
bptjm-67	131	18	blood	blood	NOUN
bptjm-67	131	19	flow	flow	NOUN
bptjm-67	131	20	in	in	ADP
bptjm-67	131	21	cerebral	cerebral	ADJ
bptjm-67	131	22	arteries	artery	NOUN
bptjm-67	131	23	,	,	PUNCT
bptjm-67	131	24	allowing	allow	VERB
bptjm-67	131	25	researchers	researcher	NOUN
bptjm-67	131	26	to	to	PART
bptjm-67	131	27	visualize	visualize	VERB
bptjm-67	131	28	circulation	circulation	NOUN
bptjm-67	131	29	patterns	pattern	NOUN
bptjm-67	131	30	throughout	throughout	ADP
bptjm-67	131	31	the	the	DET
bptjm-67	131	32	brain	brain	NOUN
bptjm-67	131	33	.	.	PUNCT
bptjm-67	132	1	carotid	carotid	NOUN
bptjm-67	132	2	artery	artery	NOUN
bptjm-67	132	3	stiffness	stiffness	NOUN
bptjm-67	132	4	is	be	AUX
bptjm-67	132	5	a	a	DET
bptjm-67	132	6	critical	critical	ADJ
bptjm-67	132	7	biomarker	biomarker	NOUN
bptjm-67	132	8	of	of	ADP
bptjm-67	132	9	cerebrovascular	cerebrovascular	ADJ
bptjm-67	132	10	aging	aging	NOUN
bptjm-67	132	11	,	,	PUNCT
bptjm-67	132	12	as	as	SCONJ
bptjm-67	132	13	reduced	reduce	VERB
bptjm-67	132	14	compliance	compliance	NOUN
bptjm-67	132	15	in	in	ADP
bptjm-67	132	16	these	these	DET
bptjm-67	132	17	vessels	vessel	NOUN
bptjm-67	132	18	can	can	AUX
bptjm-67	132	19	impair	impair	VERB
bptjm-67	132	20	cerebral	cerebral	ADJ
bptjm-67	132	21	perfusion	perfusion	NOUN
bptjm-67	132	22	.	.	PUNCT
bptjm-67	133	1	this	this	DET
bptjm-67	133	2	study	study	NOUN
bptjm-67	133	3	underscores	underscore	VERB
bptjm-67	133	4	the	the	DET
bptjm-67	133	5	potential	potential	ADJ
bptjm-67	133	6	role	role	NOUN
bptjm-67	133	7	of	of	ADP
bptjm-67	133	8	dietary	dietary	ADJ
bptjm-67	133	9	nitrate	nitrate	NOUN
bptjm-67	133	10	supplementation	supplementation	NOUN
bptjm-67	133	11	in	in	ADP
bptjm-67	133	12	supporting	support	VERB
bptjm-67	133	13	vascular	vascular	ADJ
bptjm-67	133	14	function	function	NOUN
bptjm-67	133	15	and	and	CCONJ
bptjm-67	133	16	mitigating	mitigate	VERB
bptjm-67	133	17	cognitive	cognitive	ADJ
bptjm-67	133	18	decline	decline	NOUN
bptjm-67	133	19	associated	associate	VERB
bptjm-67	133	20	with	with	ADP
bptjm-67	133	21	aging	aging	NOUN
bptjm-67	133	22	.	.	PUNCT
bptjm-67	134	1	4.7	4.7	NUM
bptjm-67	134	2	the	the	DET
bptjm-67	134	3	effect	effect	NOUN
bptjm-67	134	4	of	of	ADP
bptjm-67	134	5	nad	nad	ADJ
bptjm-67	134	6	supplementation	supplementation	NOUN
bptjm-67	134	7	on	on	ADP
bptjm-67	134	8	brain	brain	NOUN
bptjm-67	134	9	vascular	vascular	ADJ
bptjm-67	134	10	health	health	NOUN
bptjm-67	134	11	in	in	ADP
bptjm-67	134	12	aging	age	VERB
bptjm-67	134	13	the	the	DET
bptjm-67	134	14	second	second	ADJ
bptjm-67	134	15	study	study	NOUN
bptjm-67	134	16	"	"	PUNCT
bptjm-67	134	17	the	the	DET
bptjm-67	134	18	effect	effect	NOUN
bptjm-67	134	19	of	of	ADP
bptjm-67	134	20	nad	nad	ADJ
bptjm-67	134	21	supplementation	supplementation	NOUN
bptjm-67	134	22	on	on	ADP
bptjm-67	134	23	brain	brain	NOUN
bptjm-67	134	24	vascular	vascular	ADJ
bptjm-67	134	25	health	health	NOUN
bptjm-67	134	26	in	in	ADP
bptjm-67	134	27	aging	age	VERB
bptjm-67	134	28	,	,	PUNCT
bptjm-67	134	29	"	"	PUNCT
bptjm-67	134	30	delves	delf	NOUN
bptjm-67	134	31	into	into	ADP
bptjm-67	134	32	its	its	PRON
bptjm-67	134	33	effects	effect	NOUN
bptjm-67	134	34	on	on	ADP
bptjm-67	134	35	brain	brain	NOUN
bptjm-67	134	36	vascular	vascular	ADJ
bptjm-67	134	37	health	health	NOUN
bptjm-67	134	38	in	in	ADP
bptjm-67	134	39	aging	age	VERB
bptjm-67	134	40	individuals.24	individuals.24	NOUN
bptjm-67	134	41	the	the	DET
bptjm-67	134	42	objective	objective	NOUN
bptjm-67	134	43	is	be	AUX
bptjm-67	134	44	to	to	PART
bptjm-67	134	45	ascertain	ascertain	VERB
bptjm-67	134	46	whether	whether	SCONJ
bptjm-67	134	47	nicotinamide	nicotinamide	NOUN
bptjm-67	134	48	riboside	riboside	NOUN
bptjm-67	134	49	,	,	PUNCT
bptjm-67	134	50	a	a	DET
bptjm-67	134	51	precursor	precursor	NOUN
bptjm-67	134	52	to	to	ADP
bptjm-67	134	53	nad	nad	PROPN
bptjm-67	134	54	,	,	PUNCT
bptjm-67	134	55	can	can	AUX
bptjm-67	134	56	enhance	enhance	VERB
bptjm-67	134	57	brain	brain	NOUN
bptjm-67	134	58	health	health	NOUN
bptjm-67	134	59	and	and	CCONJ
bptjm-67	134	60	memory	memory	NOUN
bptjm-67	134	61	in	in	ADP
bptjm-67	134	62	older	old	ADJ
bptjm-67	134	63	adults	adult	NOUN
bptjm-67	134	64	by	by	ADP
bptjm-67	134	65	replenishing	replenish	VERB
bptjm-67	134	66	nad	nad	ADJ
bptjm-67	134	67	levels	level	NOUN
bptjm-67	134	68	.	.	PUNCT
bptjm-67	135	1	the	the	DET
bptjm-67	135	2	trial	trial	NOUN
bptjm-67	135	3	began	begin	VERB
bptjm-67	135	4	on	on	ADP
bptjm-67	135	5	may	may	PROPN
bptjm-67	135	6	3	3	NUM
bptjm-67	135	7	,	,	PUNCT
bptjm-67	135	8	2023	2023	NUM
bptjm-67	135	9	and	and	CCONJ
bptjm-67	135	10	is	be	AUX
bptjm-67	135	11	scheduled	schedule	VERB
bptjm-67	135	12	for	for	ADP
bptjm-67	135	13	completion	completion	NOUN
bptjm-67	135	14	in	in	ADP
bptjm-67	135	15	december	december	PROPN
bptjm-67	135	16	2027	2027	NUM
bptjm-67	135	17	.	.	PUNCT
bptjm-67	136	1	this	this	PRON
bptjm-67	136	2	randomized	randomize	VERB
bptjm-67	136	3	,	,	PUNCT
bptjm-67	136	4	double	double	ADJ
bptjm-67	136	5	-	-	PUNCT
bptjm-67	136	6	blind	blind	ADJ
bptjm-67	136	7	,	,	PUNCT
bptjm-67	136	8	placebo	placebo	NOUN
bptjm-67	136	9	-	-	PUNCT
bptjm-67	136	10	controlled	control	VERB
bptjm-67	136	11	parallel	parallel	ADJ
bptjm-67	136	12	study	study	NOUN
bptjm-67	136	13	involves	involve	VERB
bptjm-67	136	14	214	214	NUM
bptjm-67	136	15	community	community	NOUN
bptjm-67	136	16	-	-	PUNCT
bptjm-67	136	17	dwelling	dwell	VERB
bptjm-67	136	18	older	old	ADJ
bptjm-67	136	19	adults	adult	NOUN
bptjm-67	136	20	with	with	ADP
bptjm-67	136	21	normal	normal	ADJ
bptjm-67	136	22	cognitive	cognitive	ADJ
bptjm-67	136	23	function	function	NOUN
bptjm-67	136	24	.	.	PUNCT
bptjm-67	137	1	participants	participant	NOUN
bptjm-67	137	2	in	in	ADP
bptjm-67	137	3	the	the	DET
bptjm-67	137	4	experimental	experimental	ADJ
bptjm-67	137	5	group	group	NOUN
bptjm-67	137	6	receive	receive	VERB
bptjm-67	137	7	oral	oral	ADJ
bptjm-67	137	8	nicotinamide	nicotinamide	NOUN
bptjm-67	137	9	riboside	riboside	NOUN
bptjm-67	137	10	(	(	PUNCT
bptjm-67	137	11	1	1	NUM
bptjm-67	137	12	gram	gram	NOUN
bptjm-67	137	13	per	per	ADP
bptjm-67	137	14	day	day	NOUN
bptjm-67	137	15	)	)	PUNCT
bptjm-67	137	16	for	for	ADP
bptjm-67	137	17	8	8	NUM
bptjm-67	137	18	weeks	week	NOUN
bptjm-67	137	19	,	,	PUNCT
bptjm-67	137	20	while	while	SCONJ
bptjm-67	137	21	the	the	DET
bptjm-67	137	22	control	control	NOUN
bptjm-67	137	23	group	group	NOUN
bptjm-67	137	24	receives	receive	VERB
bptjm-67	137	25	an	an	DET
bptjm-67	137	26	indistinguishable	indistinguishable	ADJ
bptjm-67	137	27	placebo	placebo	NOUN
bptjm-67	137	28	.	.	PUNCT
bptjm-67	138	1	primary	primary	ADJ
bptjm-67	138	2	outcomes	outcome	NOUN
bptjm-67	138	3	include	include	VERB
bptjm-67	138	4	changes	change	NOUN
bptjm-67	138	5	in	in	ADP
bptjm-67	138	6	neurovascular	neurovascular	ADJ
bptjm-67	138	7	coupling	coupling	NOUN
bptjm-67	138	8	,	,	PUNCT
bptjm-67	138	9	assessed	assess	VERB
bptjm-67	138	10	using	use	VERB
bptjm-67	138	11	functional	functional	ADJ
bptjm-67	138	12	near	near	ADV
bptjm-67	138	13	-	-	PUNCT
bptjm-67	138	14	infrared	infrared	ADJ
bptjm-67	138	15	spectroscopy	spectroscopy	NOUN
bptjm-67	138	16	,	,	PUNCT
bptjm-67	138	17	and	and	CCONJ
bptjm-67	138	18	alterations	alteration	NOUN
bptjm-67	138	19	in	in	ADP
bptjm-67	138	20	neuronal	neuronal	ADJ
bptjm-67	138	21	activity	activity	NOUN
bptjm-67	138	22	,	,	PUNCT
bptjm-67	138	23	measured	measure	VERB
bptjm-67	138	24	through	through	ADP
bptjm-67	138	25	eeg	eeg	PROPN
bptjm-67	138	26	.	.	PUNCT
bptjm-67	139	1	eeg	eeg	PROPN
bptjm-67	139	2	provides	provide	VERB
bptjm-67	139	3	spectral	spectral	ADJ
bptjm-67	139	4	data	datum	NOUN
bptjm-67	139	5	through	through	ADP
bptjm-67	139	6	power	power	NOUN
bptjm-67	139	7	spectral	spectral	ADJ
bptjm-67	139	8	density	density	NOUN
bptjm-67	139	9	analysis	analysis	NOUN
bptjm-67	139	10	,	,	PUNCT
bptjm-67	139	11	enabling	enable	VERB
bptjm-67	139	12	researchers	researcher	NOUN
bptjm-67	139	13	to	to	PART
bptjm-67	139	14	assess	assess	VERB
bptjm-67	139	15	brain	brain	NOUN
bptjm-67	139	16	activity	activity	NOUN
bptjm-67	139	17	before	before	ADV
bptjm-67	139	18	and	and	CCONJ
bptjm-67	139	19	after	after	ADP
bptjm-67	139	20	treatment	treatment	NOUN
bptjm-67	139	21	,	,	PUNCT
bptjm-67	139	22	reported	report	VERB
bptjm-67	139	23	as	as	ADP
bptjm-67	139	24	a	a	DET
bptjm-67	139	25	percentage	percentage	NOUN
bptjm-67	139	26	change	change	NOUN
bptjm-67	139	27	from	from	ADP
bptjm-67	139	28	baseline	baseline	NOUN
bptjm-67	139	29	.	.	PUNCT
bptjm-67	140	1	this	this	DET
bptjm-67	140	2	study	study	NOUN
bptjm-67	140	3	is	be	AUX
bptjm-67	140	4	particularly	particularly	ADV
bptjm-67	140	5	berkeley	berkeley	PROPN
bptjm-67	140	6	pharma	pharma	PROPN
bptjm-67	140	7	tech	tech	NOUN
bptjm-67	140	8	journal	journal	NOUN
bptjm-67	140	9	of	of	ADP
bptjm-67	140	10	medicine	medicine	NOUN
bptjm-67	140	11	|	|	ADV
bptjm-67	140	12	137	137	NUM
bptjm-67	140	13	significant	significant	ADJ
bptjm-67	140	14	as	as	SCONJ
bptjm-67	140	15	it	it	PRON
bptjm-67	140	16	explores	explore	VERB
bptjm-67	140	17	the	the	DET
bptjm-67	140	18	direct	direct	ADJ
bptjm-67	140	19	impact	impact	NOUN
bptjm-67	140	20	of	of	ADP
bptjm-67	140	21	nad⁺	nad⁺	ADJ
bptjm-67	140	22	replenishment	replenishment	NOUN
bptjm-67	140	23	on	on	ADP
bptjm-67	140	24	brain	brain	NOUN
bptjm-67	140	25	vascular	vascular	ADJ
bptjm-67	140	26	health	health	NOUN
bptjm-67	140	27	,	,	PUNCT
bptjm-67	140	28	with	with	ADP
bptjm-67	140	29	the	the	DET
bptjm-67	140	30	potential	potential	NOUN
bptjm-67	140	31	to	to	PART
bptjm-67	140	32	prevent	prevent	VERB
bptjm-67	140	33	or	or	CCONJ
bptjm-67	140	34	delay	delay	VERB
bptjm-67	140	35	cognitive	cognitive	ADJ
bptjm-67	140	36	decline	decline	NOUN
bptjm-67	140	37	in	in	ADP
bptjm-67	140	38	the	the	DET
bptjm-67	140	39	aging	age	VERB
bptjm-67	140	40	population	population	NOUN
bptjm-67	140	41	.	.	PUNCT
bptjm-67	141	1	5	5	X
bptjm-67	141	2	.	.	X
bptjm-67	141	3	future	future	ADJ
bptjm-67	141	4	directions	direction	NOUN
bptjm-67	141	5	future	future	ADJ
bptjm-67	141	6	directions	direction	NOUN
bptjm-67	141	7	of	of	ADP
bptjm-67	141	8	research	research	NOUN
bptjm-67	141	9	on	on	ADP
bptjm-67	141	10	nvc	nvc	NOUN
bptjm-67	141	11	-	-	PUNCT
bptjm-67	141	12	associated	associate	VERB
bptjm-67	141	13	cognitive	cognitive	ADJ
bptjm-67	141	14	decline	decline	NOUN
bptjm-67	141	15	could	could	AUX
bptjm-67	141	16	include	include	VERB
bptjm-67	141	17	conducting	conduct	VERB
bptjm-67	141	18	longitudinal	longitudinal	ADJ
bptjm-67	141	19	studies	study	NOUN
bptjm-67	141	20	spanning	span	VERB
bptjm-67	141	21	5	5	NUM
bptjm-67	141	22	-	-	SYM
bptjm-67	141	23	10	10	NUM
bptjm-67	141	24	years	year	NOUN
bptjm-67	141	25	to	to	PART
bptjm-67	141	26	track	track	VERB
bptjm-67	141	27	the	the	DET
bptjm-67	141	28	efficacy	efficacy	NOUN
bptjm-67	141	29	of	of	ADP
bptjm-67	141	30	interventions	intervention	NOUN
bptjm-67	141	31	targeting	target	VERB
bptjm-67	141	32	nvc	nvc	NOUN
bptjm-67	141	33	in	in	ADP
bptjm-67	141	34	individuals	individual	NOUN
bptjm-67	141	35	with	with	ADP
bptjm-67	141	36	cognitive	cognitive	ADJ
bptjm-67	141	37	impairments	impairment	NOUN
bptjm-67	141	38	.	.	PUNCT
bptjm-67	142	1	this	this	PRON
bptjm-67	142	2	could	could	AUX
bptjm-67	142	3	also	also	ADV
bptjm-67	142	4	include	include	VERB
bptjm-67	142	5	the	the	DET
bptjm-67	142	6	development	development	NOUN
bptjm-67	142	7	of	of	ADP
bptjm-67	142	8	combination	combination	NOUN
bptjm-67	142	9	therapies	therapy	NOUN
bptjm-67	142	10	,	,	PUNCT
bptjm-67	142	11	such	such	ADJ
bptjm-67	142	12	as	as	ADP
bptjm-67	142	13	medicinal	medicinal	ADJ
bptjm-67	142	14	treatments	treatment	NOUN
bptjm-67	142	15	and	and	CCONJ
bptjm-67	142	16	lifestyle	lifestyle	NOUN
bptjm-67	142	17	interventions	intervention	NOUN
bptjm-67	142	18	to	to	PART
bptjm-67	142	19	investigate	investigate	VERB
bptjm-67	142	20	the	the	DET
bptjm-67	142	21	benefits	benefit	NOUN
bptjm-67	142	22	of	of	ADP
bptjm-67	142	23	improving	improve	VERB
bptjm-67	142	24	overall	overall	ADJ
bptjm-67	142	25	well	well	ADV
bptjm-67	142	26	-	-	PUNCT
bptjm-67	142	27	being	being	NOUN
bptjm-67	142	28	on	on	ADP
bptjm-67	142	29	brain	brain	NOUN
bptjm-67	142	30	health	health	NOUN
bptjm-67	142	31	.	.	PUNCT
bptjm-67	143	1	in	in	ADP
bptjm-67	143	2	addition	addition	NOUN
bptjm-67	143	3	,	,	PUNCT
bptjm-67	143	4	genetic	genetic	ADJ
bptjm-67	143	5	factors	factor	NOUN
bptjm-67	143	6	play	play	VERB
bptjm-67	143	7	a	a	DET
bptjm-67	143	8	critical	critical	ADJ
bptjm-67	143	9	role	role	NOUN
bptjm-67	143	10	in	in	ADP
bptjm-67	143	11	cognitive	cognitive	ADJ
bptjm-67	143	12	decline	decline	NOUN
bptjm-67	143	13	and	and	CCONJ
bptjm-67	143	14	warrant	warrant	VERB
bptjm-67	143	15	deeper	deep	ADJ
bptjm-67	143	16	investigation	investigation	NOUN
bptjm-67	143	17	.	.	PUNCT
bptjm-67	144	1	while	while	SCONJ
bptjm-67	144	2	the	the	DET
bptjm-67	144	3	apoeε4	apoeε4	PROPN
bptjm-67	144	4	allele	allele	PROPN
bptjm-67	144	5	is	be	AUX
bptjm-67	144	6	a	a	DET
bptjm-67	144	7	well	well	ADV
bptjm-67	144	8	-	-	PUNCT
bptjm-67	144	9	known	know	VERB
bptjm-67	144	10	genetic	genetic	ADJ
bptjm-67	144	11	risk	risk	NOUN
bptjm-67	144	12	factor	factor	NOUN
bptjm-67	144	13	,	,	PUNCT
bptjm-67	144	14	emerging	emerge	VERB
bptjm-67	144	15	evidence	evidence	NOUN
bptjm-67	144	16	suggests	suggest	VERB
bptjm-67	144	17	that	that	SCONJ
bptjm-67	144	18	other	other	ADJ
bptjm-67	144	19	genes	gene	NOUN
bptjm-67	144	20	—	—	PUNCT
bptjm-67	144	21	such	such	ADJ
bptjm-67	144	22	as	as	ADP
bptjm-67	144	23	cldn5	cldn5	PROPN
bptjm-67	144	24	,	,	PUNCT
bptjm-67	144	25	which	which	PRON
bptjm-67	144	26	is	be	AUX
bptjm-67	144	27	associated	associate	VERB
bptjm-67	144	28	with	with	ADP
bptjm-67	144	29	blood	blood	NOUN
bptjm-67	144	30	–	–	PUNCT
bptjm-67	144	31	brain	brain	NOUN
bptjm-67	144	32	barrier	barrier	NOUN
bptjm-67	144	33	integrity	integrity	NOUN
bptjm-67	144	34	—	—	PUNCT
bptjm-67	144	35	may	may	AUX
bptjm-67	144	36	also	also	ADV
bptjm-67	144	37	be	be	AUX
bptjm-67	144	38	implicated	implicate	VERB
bptjm-67	144	39	in	in	ADP
bptjm-67	144	40	nvc	nvc	PROPN
bptjm-67	144	41	dysfunction.21	dysfunction.21	NOUN
bptjm-67	144	42	future	future	ADJ
bptjm-67	144	43	research	research	NOUN
bptjm-67	144	44	could	could	AUX
bptjm-67	144	45	explore	explore	VERB
bptjm-67	144	46	epigenetic	epigenetic	ADJ
bptjm-67	144	47	approaches	approach	NOUN
bptjm-67	144	48	,	,	PUNCT
bptjm-67	144	49	including	include	VERB
bptjm-67	144	50	gene	gene	NOUN
bptjm-67	144	51	expression	expression	NOUN
bptjm-67	144	52	modulation	modulation	NOUN
bptjm-67	144	53	,	,	PUNCT
bptjm-67	144	54	as	as	ADP
bptjm-67	144	55	a	a	DET
bptjm-67	144	56	potential	potential	ADJ
bptjm-67	144	57	therapeutic	therapeutic	ADJ
bptjm-67	144	58	strategy	strategy	NOUN
bptjm-67	144	59	for	for	ADP
bptjm-67	144	60	nvc	nvc	NOUN
bptjm-67	144	61	-	-	PUNCT
bptjm-67	144	62	related	relate	VERB
bptjm-67	144	63	diseases	disease	NOUN
bptjm-67	144	64	.	.	PUNCT
bptjm-67	145	1	6	6	X
bptjm-67	145	2	.	.	X
bptjm-67	145	3	conclusion	conclusion	NOUN
bptjm-67	145	4	as	as	SCONJ
bptjm-67	145	5	discussed	discuss	VERB
bptjm-67	145	6	,	,	PUNCT
bptjm-67	145	7	the	the	DET
bptjm-67	145	8	growing	grow	VERB
bptjm-67	145	9	prevalence	prevalence	NOUN
bptjm-67	145	10	of	of	ADP
bptjm-67	145	11	cognitive	cognitive	ADJ
bptjm-67	145	12	decline	decline	NOUN
bptjm-67	145	13	,	,	PUNCT
bptjm-67	145	14	including	include	VERB
bptjm-67	145	15	alzheimer	alzheimer	PROPN
bptjm-67	145	16	’s	’s	NOUN
bptjm-67	145	17	,	,	PUNCT
bptjm-67	145	18	parkinson	parkinson	NOUN
bptjm-67	145	19	’s	’s	PART
bptjm-67	145	20	,	,	PUNCT
bptjm-67	145	21	and	and	CCONJ
bptjm-67	145	22	dementia	dementia	NOUN
bptjm-67	145	23	,	,	PUNCT
bptjm-67	145	24	presents	present	VERB
bptjm-67	145	25	a	a	DET
bptjm-67	145	26	significant	significant	ADJ
bptjm-67	145	27	challenge	challenge	NOUN
bptjm-67	145	28	to	to	ADP
bptjm-67	145	29	public	public	ADJ
bptjm-67	145	30	health	health	NOUN
bptjm-67	145	31	systems	system	NOUN
bptjm-67	145	32	worldwide	worldwide	ADV
bptjm-67	145	33	.	.	PUNCT
bptjm-67	146	1	this	this	DET
bptjm-67	146	2	review	review	NOUN
bptjm-67	146	3	highlights	highlight	VERB
bptjm-67	146	4	the	the	DET
bptjm-67	146	5	important	important	ADJ
bptjm-67	146	6	role	role	NOUN
bptjm-67	146	7	of	of	ADP
bptjm-67	146	8	nvc	nvc	NOUN
bptjm-67	146	9	in	in	ADP
bptjm-67	146	10	regulating	regulate	VERB
bptjm-67	146	11	cerebral	cerebral	ADJ
bptjm-67	146	12	blood	blood	NOUN
bptjm-67	146	13	flow	flow	NOUN
bptjm-67	146	14	and	and	CCONJ
bptjm-67	146	15	brain	brain	NOUN
bptjm-67	146	16	health	health	NOUN
bptjm-67	146	17	,	,	PUNCT
bptjm-67	146	18	both	both	PRON
bptjm-67	146	19	of	of	ADP
bptjm-67	146	20	which	which	PRON
bptjm-67	146	21	are	be	AUX
bptjm-67	146	22	essential	essential	ADJ
bptjm-67	146	23	in	in	ADP
bptjm-67	146	24	mitigating	mitigate	VERB
bptjm-67	146	25	cognitive	cognitive	ADJ
bptjm-67	146	26	decline	decline	NOUN
bptjm-67	146	27	and	and	CCONJ
bptjm-67	146	28	managing	manage	VERB
bptjm-67	146	29	neurodegenerative	neurodegenerative	ADJ
bptjm-67	146	30	diseases	disease	NOUN
bptjm-67	146	31	.	.	PUNCT
bptjm-67	147	1	innovations	innovation	NOUN
bptjm-67	147	2	in	in	ADP
bptjm-67	147	3	biomarkers	biomarker	NOUN
bptjm-67	147	4	–	–	PUNCT
bptjm-67	147	5	pericyte	pericyte	NOUN
bptjm-67	147	6	detachment	detachment	NOUN
bptjm-67	147	7	,	,	PUNCT
bptjm-67	147	8	apoeε4	apoeε4	NOUN
bptjm-67	147	9	gene	gene	NOUN
bptjm-67	147	10	expression	expression	NOUN
bptjm-67	147	11	,	,	PUNCT
bptjm-67	147	12	vascular	vascular	ADJ
bptjm-67	147	13	dysfunction	dysfunction	NOUN
bptjm-67	147	14	in	in	ADP
bptjm-67	147	15	accordance	accordance	NOUN
bptjm-67	147	16	with	with	ADP
bptjm-67	147	17	the	the	DET
bptjm-67	147	18	2	2	NUM
bptjm-67	147	19	-	-	PUNCT
bptjm-67	147	20	hit	hit	VERB
bptjm-67	147	21	hypothesis	hypothesis	NOUN
bptjm-67	147	22	model	model	NOUN
bptjm-67	147	23	,	,	PUNCT
bptjm-67	147	24	and	and	CCONJ
bptjm-67	147	25	bbb	bbb	NOUN
bptjm-67	147	26	breakdown	breakdown	NOUN
bptjm-67	147	27	–	–	PUNCT
bptjm-67	147	28	and	and	CCONJ
bptjm-67	147	29	advanced	advanced	ADJ
bptjm-67	147	30	neuroimaging	neuroimaging	NOUN
bptjm-67	147	31	techniques	technique	NOUN
bptjm-67	147	32	–	–	PUNCT
bptjm-67	147	33	in	in	ADP
bptjm-67	147	34	-	-	PUNCT
bptjm-67	147	35	vivo	vivo	NOUN
bptjm-67	147	36	photon	photon	NOUN
bptjm-67	147	37	imaging	imaging	NOUN
bptjm-67	147	38	,	,	PUNCT
bptjm-67	147	39	dynamic	dynamic	ADJ
bptjm-67	147	40	vessel	vessel	NOUN
bptjm-67	147	41	analyzer	analyzer	NOUN
bptjm-67	147	42	,	,	PUNCT
bptjm-67	147	43	multimodality	multimodality	NOUN
bptjm-67	147	44	imaging	imaging	NOUN
bptjm-67	147	45	platforms	platform	NOUN
bptjm-67	147	46	,	,	PUNCT
bptjm-67	147	47	fmri	fmri	NOUN
bptjm-67	147	48	,	,	PUNCT
bptjm-67	147	49	fnirs	fnir	NOUN
bptjm-67	147	50	–	–	PUNCT
bptjm-67	147	51	can	can	AUX
bptjm-67	147	52	be	be	AUX
bptjm-67	147	53	the	the	DET
bptjm-67	147	54	key	key	NOUN
bptjm-67	147	55	for	for	ADP
bptjm-67	147	56	the	the	DET
bptjm-67	147	57	early	early	ADJ
bptjm-67	147	58	detection	detection	NOUN
bptjm-67	147	59	and	and	CCONJ
bptjm-67	147	60	combating	combating	NOUN
bptjm-67	147	61	of	of	ADP
bptjm-67	147	62	nvc	nvc	NOUN
bptjm-67	147	63	-	-	PUNCT
bptjm-67	147	64	related	relate	VERB
bptjm-67	147	65	diseases	disease	NOUN
bptjm-67	147	66	.	.	PUNCT
bptjm-67	148	1	additionally	additionally	ADV
bptjm-67	148	2	,	,	PUNCT
bptjm-67	148	3	nvc	nvc	NOUN
bptjm-67	148	4	-	-	PUNCT
bptjm-67	148	5	targeting	target	VERB
bptjm-67	148	6	market	market	NOUN
bptjm-67	148	7	therapeutics	therapeutic	NOUN
bptjm-67	148	8	provide	provide	VERB
bptjm-67	148	9	a	a	DET
bptjm-67	148	10	look	look	NOUN
bptjm-67	148	11	into	into	ADP
bptjm-67	148	12	future	future	ADJ
bptjm-67	148	13	treatment	treatment	NOUN
bptjm-67	148	14	.	.	PUNCT
bptjm-67	149	1	substances	substance	NOUN
bptjm-67	149	2	like	like	ADP
bptjm-67	149	3	cocoa	cocoa	NOUN
bptjm-67	149	4	flavonoids	flavonoid	NOUN
bptjm-67	149	5	and	and	CCONJ
bptjm-67	149	6	inorganic	inorganic	ADJ
bptjm-67	149	7	nitrate	nitrate	NOUN
bptjm-67	149	8	supplementation	supplementation	NOUN
bptjm-67	149	9	are	be	AUX
bptjm-67	149	10	being	be	AUX
bptjm-67	149	11	explored	explore	VERB
bptjm-67	149	12	for	for	ADP
bptjm-67	149	13	their	their	PRON
bptjm-67	149	14	potential	potential	ADJ
bptjm-67	149	15	benefits	benefit	NOUN
bptjm-67	149	16	in	in	ADP
bptjm-67	149	17	improving	improve	VERB
bptjm-67	149	18	brain	brain	NOUN
bptjm-67	149	19	vascular	vascular	ADJ
bptjm-67	149	20	health	health	NOUN
bptjm-67	149	21	and	and	CCONJ
bptjm-67	149	22	cognitive	cognitive	ADJ
bptjm-67	149	23	function	function	NOUN
bptjm-67	149	24	.	.	PUNCT
bptjm-67	150	1	with	with	ADP
bptjm-67	150	2	berkeley	berkeley	PROPN
bptjm-67	150	3	pharma	pharma	PROPN
bptjm-67	150	4	tech	tech	NOUN
bptjm-67	150	5	journal	journal	NOUN
bptjm-67	150	6	of	of	ADP
bptjm-67	150	7	medicine	medicine	NOUN
bptjm-67	151	1	|	|	ADV
bptjm-67	151	2	138	138	NUM
bptjm-67	151	3	continued	continued	ADJ
bptjm-67	151	4	research	research	NOUN
bptjm-67	151	5	,	,	PUNCT
bptjm-67	151	6	these	these	DET
bptjm-67	151	7	market	market	NOUN
bptjm-67	151	8	therapies	therapy	NOUN
bptjm-67	151	9	could	could	AUX
bptjm-67	151	10	be	be	AUX
bptjm-67	151	11	developed	develop	VERB
bptjm-67	151	12	into	into	ADP
bptjm-67	151	13	effective	effective	ADJ
bptjm-67	151	14	treatments	treatment	NOUN
bptjm-67	151	15	for	for	ADP
bptjm-67	151	16	both	both	CCONJ
bptjm-67	151	17	early	early	ADJ
bptjm-67	151	18	and	and	CCONJ
bptjm-67	151	19	late	late	ADJ
bptjm-67	151	20	stages	stage	NOUN
bptjm-67	151	21	of	of	ADP
bptjm-67	151	22	nvc	nvc	NOUN
bptjm-67	151	23	-	-	PUNCT
bptjm-67	151	24	related	relate	VERB
bptjm-67	151	25	symptoms	symptom	NOUN
bptjm-67	151	26	.	.	PUNCT
bptjm-67	152	1	ongoing	ongoing	ADJ
bptjm-67	152	2	research	research	NOUN
bptjm-67	152	3	is	be	AUX
bptjm-67	152	4	necessary	necessary	ADJ
bptjm-67	152	5	to	to	PART
bptjm-67	152	6	refine	refine	VERB
bptjm-67	152	7	these	these	DET
bptjm-67	152	8	therapies	therapy	NOUN
bptjm-67	152	9	to	to	PART
bptjm-67	152	10	ensure	ensure	VERB
bptjm-67	152	11	both	both	DET
bptjm-67	152	12	effectiveness	effectiveness	NOUN
bptjm-67	152	13	and	and	CCONJ
bptjm-67	152	14	safety	safety	NOUN
bptjm-67	152	15	across	across	ADP
bptjm-67	152	16	various	various	ADJ
bptjm-67	152	17	stages	stage	NOUN
bptjm-67	152	18	of	of	ADP
bptjm-67	152	19	disease	disease	NOUN
bptjm-67	152	20	progression	progression	NOUN
bptjm-67	152	21	.	.	PUNCT
bptjm-67	153	1	although	although	SCONJ
bptjm-67	153	2	many	many	ADJ
bptjm-67	153	3	of	of	ADP
bptjm-67	153	4	these	these	DET
bptjm-67	153	5	interventions	intervention	NOUN
bptjm-67	153	6	are	be	AUX
bptjm-67	153	7	still	still	ADV
bptjm-67	153	8	in	in	ADP
bptjm-67	153	9	early	early	ADJ
bptjm-67	153	10	-	-	PUNCT
bptjm-67	153	11	stage	stage	NOUN
bptjm-67	153	12	research	research	NOUN
bptjm-67	153	13	and	and	CCONJ
bptjm-67	153	14	suffer	suffer	VERB
bptjm-67	153	15	from	from	ADP
bptjm-67	153	16	limited	limited	ADJ
bptjm-67	153	17	funding	funding	NOUN
bptjm-67	153	18	and	and	CCONJ
bptjm-67	153	19	clinical	clinical	ADJ
bptjm-67	153	20	validation	validation	NOUN
bptjm-67	153	21	,	,	PUNCT
bptjm-67	153	22	they	they	PRON
bptjm-67	153	23	show	show	VERB
bptjm-67	153	24	promise	promise	NOUN
bptjm-67	153	25	for	for	ADP
bptjm-67	153	26	future	future	ADJ
bptjm-67	153	27	therapeutic	therapeutic	ADJ
bptjm-67	153	28	development	development	NOUN
bptjm-67	153	29	.	.	PUNCT
bptjm-67	154	1	in	in	ADP
bptjm-67	154	2	summary	summary	NOUN
bptjm-67	154	3	,	,	PUNCT
bptjm-67	154	4	the	the	DET
bptjm-67	154	5	integration	integration	NOUN
bptjm-67	154	6	of	of	ADP
bptjm-67	154	7	advanced	advanced	ADJ
bptjm-67	154	8	neuroimaging	neuroimaging	NOUN
bptjm-67	154	9	techniques	technique	NOUN
bptjm-67	154	10	with	with	ADP
bptjm-67	154	11	targeted	target	VERB
bptjm-67	154	12	biomarker	biomarker	NOUN
bptjm-67	154	13	detection	detection	NOUN
bptjm-67	154	14	holds	hold	VERB
bptjm-67	154	15	considerable	considerable	ADJ
bptjm-67	154	16	promise	promise	NOUN
bptjm-67	154	17	for	for	ADP
bptjm-67	154	18	improving	improve	VERB
bptjm-67	154	19	the	the	DET
bptjm-67	154	20	early	early	ADJ
bptjm-67	154	21	diagnosis	diagnosis	NOUN
bptjm-67	154	22	,	,	PUNCT
bptjm-67	154	23	monitoring	monitoring	NOUN
bptjm-67	154	24	,	,	PUNCT
bptjm-67	154	25	and	and	CCONJ
bptjm-67	154	26	treatment	treatment	NOUN
bptjm-67	154	27	of	of	ADP
bptjm-67	154	28	cognitive	cognitive	ADJ
bptjm-67	154	29	decline	decline	NOUN
bptjm-67	154	30	.	.	PUNCT
bptjm-67	155	1	focusing	focus	VERB
bptjm-67	155	2	on	on	ADP
bptjm-67	155	3	the	the	DET
bptjm-67	155	4	neurovascular	neurovascular	ADJ
bptjm-67	155	5	unit	unit	NOUN
bptjm-67	155	6	as	as	ADP
bptjm-67	155	7	a	a	DET
bptjm-67	155	8	therapeutic	therapeutic	ADJ
bptjm-67	155	9	target	target	NOUN
bptjm-67	155	10	may	may	AUX
bptjm-67	155	11	pave	pave	VERB
bptjm-67	155	12	the	the	DET
bptjm-67	155	13	way	way	NOUN
bptjm-67	155	14	for	for	ADP
bptjm-67	155	15	more	more	ADV
bptjm-67	155	16	effective	effective	ADJ
bptjm-67	155	17	and	and	CCONJ
bptjm-67	155	18	personalized	personalized	ADJ
bptjm-67	155	19	interventions	intervention	NOUN
bptjm-67	155	20	in	in	ADP
bptjm-67	155	21	the	the	DET
bptjm-67	155	22	fight	fight	NOUN
bptjm-67	155	23	against	against	ADP
bptjm-67	155	24	neurodegenerative	neurodegenerative	ADJ
bptjm-67	155	25	diseases	disease	NOUN
bptjm-67	155	26	.	.	PUNCT
bptjm-67	156	1	berkeley	berkeley	PROPN
bptjm-67	156	2	pharma	pharma	PROPN
bptjm-67	156	3	tech	tech	PROPN
bptjm-67	156	4	journal	journal	NOUN
bptjm-67	156	5	of	of	ADP
bptjm-67	156	6	medicine	medicine	NOUN
bptjm-67	156	7	|	|	ADV
bptjm-67	156	8	139	139	NUM
bptjm-67	156	9	references	reference	NOUN
bptjm-67	156	10	1	1	NUM
bptjm-67	156	11	.	.	PUNCT
bptjm-67	157	1	hale	hale	PROPN
bptjm-67	157	2	jm	jm	PROPN
bptjm-67	157	3	,	,	PUNCT
bptjm-67	157	4	schneider	schneider	PROPN
bptjm-67	157	5	dc	dc	PROPN
bptjm-67	157	6	,	,	PUNCT
bptjm-67	157	7	gampe	gampe	PROPN
bptjm-67	157	8	j	j	PROPN
bptjm-67	157	9	,	,	PUNCT
bptjm-67	157	10	mehta	mehta	PROPN
bptjm-67	157	11	nk	nk	PROPN
bptjm-67	157	12	,	,	PUNCT
bptjm-67	157	13	myrskylä	myrskylä	NOUN
bptjm-67	157	14	m.	m.	NOUN
bptjm-67	157	15	trends	trend	NOUN
bptjm-67	157	16	in	in	ADP
bptjm-67	157	17	the	the	DET
bptjm-67	157	18	risk	risk	NOUN
bptjm-67	157	19	of	of	ADP
bptjm-67	157	20	cognitive	cognitive	ADJ
bptjm-67	157	21	impairment	impairment	NOUN
bptjm-67	157	22	in	in	ADP
bptjm-67	157	23	the	the	DET
bptjm-67	157	24	united	united	PROPN
bptjm-67	157	25	states	states	PROPN
bptjm-67	157	26	,	,	PUNCT
bptjm-67	157	27	1996–2014	1996–2014	NUM
bptjm-67	157	28	.	.	PUNCT
bptjm-67	158	1	epidemiology	epidemiology	NOUN
bptjm-67	158	2	.	.	PUNCT
bptjm-67	159	1	2020;31(5):745–754	2020;31(5):745–754	NUM
bptjm-67	159	2	.	.	PUNCT
bptjm-67	160	1	doi:10.1097	doi:10.1097	PROPN
bptjm-67	160	2	/	/	SYM
bptjm-67	161	1	ede.0000000000001219	ede.0000000000001219	PROPN
bptjm-67	161	2	2	2	NUM
bptjm-67	161	3	.	.	PUNCT
bptjm-67	161	4	pais	pais	PROPN
bptjm-67	161	5	r	r	NOUN
bptjm-67	161	6	,	,	PUNCT
bptjm-67	161	7	ruano	ruano	PROPN
bptjm-67	161	8	l	l	NOUN
bptjm-67	161	9	,	,	PUNCT
bptjm-67	161	10	carvalho	carvalho	NOUN
bptjm-67	161	11	op	op	NOUN
bptjm-67	161	12	,	,	PUNCT
bptjm-67	161	13	barros	barros	PROPN
bptjm-67	161	14	h.	h.	PROPN
bptjm-67	161	15	global	global	PROPN
bptjm-67	161	16	cognitive	cognitive	ADJ
bptjm-67	161	17	impairment	impairment	ADJ
bptjm-67	161	18	prevalence	prevalence	NOUN
bptjm-67	161	19	and	and	CCONJ
bptjm-67	161	20	incidence	incidence	NOUN
bptjm-67	161	21	in	in	ADP
bptjm-67	161	22	community	community	NOUN
bptjm-67	161	23	-	-	PUNCT
bptjm-67	161	24	dwelling	dwell	VERB
bptjm-67	161	25	older	old	ADJ
bptjm-67	161	26	adults	adult	NOUN
bptjm-67	161	27	:	:	PUNCT
bptjm-67	161	28	a	a	DET
bptjm-67	161	29	systematic	systematic	ADJ
bptjm-67	161	30	review	review	NOUN
bptjm-67	161	31	.	.	PUNCT
bptjm-67	162	1	geriatrics	geriatric	NOUN
bptjm-67	162	2	(	(	PUNCT
bptjm-67	162	3	basel	basel	PROPN
bptjm-67	162	4	)	)	PUNCT
bptjm-67	162	5	.	.	PUNCT
bptjm-67	163	1	2020;5(4):84	2020;5(4):84	X
bptjm-67	163	2	.	.	PUNCT
bptjm-67	163	3	doi:10.3390	doi:10.3390	PROPN
bptjm-67	163	4	/	/	SYM
bptjm-67	163	5	geriatrics5040084	geriatrics5040084	PROPN
bptjm-67	163	6	3	3	NUM
bptjm-67	163	7	.	.	PUNCT
bptjm-67	164	1	hale	hale	PROPN
bptjm-67	164	2	jm	jm	PROPN
bptjm-67	164	3	,	,	PUNCT
bptjm-67	164	4	schneider	schneider	PROPN
bptjm-67	164	5	dc	dc	PROPN
bptjm-67	164	6	,	,	PUNCT
bptjm-67	164	7	mehta	mehta	PROPN
bptjm-67	164	8	nk	nk	PROPN
bptjm-67	164	9	,	,	PUNCT
bptjm-67	164	10	myrskylä	myrskylä	NOUN
bptjm-67	164	11	m.	m.	NOUN
bptjm-67	164	12	cognitive	cognitive	ADJ
bptjm-67	164	13	impairment	impairment	NOUN
bptjm-67	164	14	in	in	ADP
bptjm-67	164	15	the	the	DET
bptjm-67	164	16	u.s	u.s	PROPN
bptjm-67	164	17	.	.	PROPN
bptjm-67	164	18	:	:	PUNCT
bptjm-67	164	19	lifetime	lifetime	NOUN
bptjm-67	164	20	risk	risk	NOUN
bptjm-67	164	21	,	,	PUNCT
bptjm-67	164	22	age	age	NOUN
bptjm-67	164	23	at	at	ADP
bptjm-67	164	24	onset	onset	NOUN
bptjm-67	164	25	,	,	PUNCT
bptjm-67	164	26	and	and	CCONJ
bptjm-67	164	27	years	year	NOUN
bptjm-67	164	28	impaired	impair	VERB
bptjm-67	164	29	.	.	PUNCT
bptjm-67	165	1	ssm	ssm	PROPN
bptjm-67	165	2	popul	popul	PROPN
bptjm-67	165	3	health	health	NOUN
bptjm-67	165	4	.	.	PUNCT
bptjm-67	166	1	2020;11:100577	2020;11:100577	NUM
bptjm-67	166	2	.	.	PUNCT
bptjm-67	166	3	doi:10.1016	doi:10.1016	PROPN
bptjm-67	166	4	/	/	SYM
bptjm-67	166	5	j.ssmph.2020.100577	j.ssmph.2020.100577	PROPN
bptjm-67	166	6	4	4	NUM
bptjm-67	166	7	.	.	PUNCT
bptjm-67	166	8	cleveland	cleveland	PROPN
bptjm-67	166	9	clinic	clinic	PROPN
bptjm-67	166	10	.	.	PUNCT
bptjm-67	167	1	alzheimer	alzheimer	PROPN
bptjm-67	167	2	’s	’s	PART
bptjm-67	167	3	disease	disease	NOUN
bptjm-67	167	4	:	:	PUNCT
bptjm-67	167	5	causes	cause	NOUN
bptjm-67	167	6	,	,	PUNCT
bptjm-67	167	7	symptoms	symptom	NOUN
bptjm-67	167	8	,	,	PUNCT
bptjm-67	167	9	treatment	treatment	NOUN
bptjm-67	167	10	&	&	CCONJ
bptjm-67	167	11	stages	stage	NOUN
bptjm-67	167	12	.	.	PUNCT
bptjm-67	168	1	accessed	access	VERB
bptjm-67	168	2	april	april	PROPN
bptjm-67	168	3	26	26	NUM
bptjm-67	168	4	,	,	PUNCT
bptjm-67	168	5	2024	2024	NUM
bptjm-67	168	6	.	.	PUNCT
bptjm-67	169	1	https://my.clevelandclinic.org/health/diseases/	https://my.clevelandclinic.org/health/diseases/	PROPN
bptjm-67	169	2	9164	9164	NUM
bptjm-67	169	3	-	-	PUNCT
bptjm-67	169	4	alzheimers	alzheimer	NOUN
bptjm-67	169	5	-	-	PUNCT
bptjm-67	169	6	disease	disease	NOUN
bptjm-67	169	7	5	5	NUM
bptjm-67	169	8	.	.	PUNCT
bptjm-67	169	9	cleveland	cleveland	PROPN
bptjm-67	169	10	clinic	clinic	PROPN
bptjm-67	169	11	.	.	PUNCT
bptjm-67	170	1	parkinson	parkinson	PROPN
bptjm-67	170	2	’s	’s	PART
bptjm-67	170	3	disease	disease	NOUN
bptjm-67	170	4	:	:	PUNCT
bptjm-67	170	5	what	what	PRON
bptjm-67	170	6	it	it	PRON
bptjm-67	170	7	is	be	AUX
bptjm-67	170	8	,	,	PUNCT
bptjm-67	170	9	causes	cause	NOUN
bptjm-67	170	10	,	,	PUNCT
bptjm-67	170	11	symptoms	symptom	NOUN
bptjm-67	170	12	&	&	CCONJ
bptjm-67	170	13	treatment	treatment	NOUN
bptjm-67	170	14	.	.	PUNCT
bptjm-67	171	1	accessed	access	VERB
bptjm-67	171	2	april	april	PROPN
bptjm-67	171	3	26	26	NUM
bptjm-67	171	4	,	,	PUNCT
bptjm-67	171	5	2024	2024	NUM
bptjm-67	171	6	.	.	PUNCT
bptjm-67	172	1	https://my.clevelandclinic.org/health/diseases/85	https://my.clevelandclinic.org/health/diseases/85	PROPN
bptjm-67	172	2	25	25	NUM
bptjm-67	172	3	-	-	PUNCT
bptjm-67	172	4	parkinsons	parkinson	NOUN
bptjm-67	172	5	-	-	PUNCT
bptjm-67	172	6	disease	disease	NOUN
bptjm-67	172	7	-	-	PUNCT
bptjm-67	172	8	an	an	DET
bptjm-67	172	9	-	-	PUNCT
bptjm-67	172	10	overview	overview	NOUN
bptjm-67	172	11	6	6	NUM
bptjm-67	172	12	.	.	PUNCT
bptjm-67	173	1	centers	center	NOUN
bptjm-67	173	2	for	for	ADP
bptjm-67	173	3	disease	disease	NOUN
bptjm-67	173	4	control	control	NOUN
bptjm-67	173	5	and	and	CCONJ
bptjm-67	173	6	prevention	prevention	NOUN
bptjm-67	173	7	.	.	PUNCT
bptjm-67	174	1	what	what	PRON
bptjm-67	174	2	is	be	AUX
bptjm-67	174	3	dementia	dementia	NOUN
bptjm-67	174	4	?	?	PUNCT
bptjm-67	175	1	published	publish	VERB
bptjm-67	175	2	april	april	PROPN
bptjm-67	175	3	5	5	NUM
bptjm-67	175	4	,	,	PUNCT
bptjm-67	175	5	2019	2019	NUM
bptjm-67	175	6	.	.	PUNCT
bptjm-67	176	1	accessed	access	VERB
bptjm-67	176	2	april	april	PROPN
bptjm-67	176	3	26	26	NUM
bptjm-67	176	4	,	,	PUNCT
bptjm-67	176	5	2024	2024	NUM
bptjm-67	176	6	.	.	PUNCT
bptjm-67	177	1	https://www.cdc.gov/aging/dementia/index.html	https://www.cdc.gov/aging/dementia/index.html	PROPN
bptjm-67	178	1	7	7	NUM
bptjm-67	178	2	.	.	PUNCT
bptjm-67	179	1	feng	feng	PROPN
bptjm-67	179	2	l	l	PROPN
bptjm-67	179	3	,	,	PUNCT
bptjm-67	179	4	gao	gao	PROPN
bptjm-67	179	5	l.	l.	PROPN
bptjm-67	179	6	the	the	DET
bptjm-67	179	7	role	role	NOUN
bptjm-67	179	8	of	of	ADP
bptjm-67	179	9	neurovascular	neurovascular	ADJ
bptjm-67	179	10	coupling	couple	VERB
bptjm-67	179	11	dysfunction	dysfunction	NOUN
bptjm-67	179	12	in	in	ADP
bptjm-67	179	13	cognitive	cognitive	ADJ
bptjm-67	179	14	decline	decline	NOUN
bptjm-67	179	15	of	of	ADP
bptjm-67	179	16	diabetes	diabetes	NOUN
bptjm-67	179	17	patients	patient	NOUN
bptjm-67	179	18	.	.	PUNCT
bptjm-67	180	1	front	front	ADJ
bptjm-67	180	2	neurosci	neurosci	NOUN
bptjm-67	180	3	.	.	PUNCT
bptjm-67	181	1	2024;18:1375908	2024;18:1375908	NUM
bptjm-67	181	2	.	.	X
bptjm-67	181	3	doi:10.3389	doi:10.3389	PROPN
bptjm-67	181	4	/	/	SYM
bptjm-67	181	5	fnins.2024.1375908	fnins.2024.1375908	PROPN
bptjm-67	181	6	8	8	NUM
bptjm-67	181	7	.	.	PUNCT
bptjm-67	182	1	das	das	PROPN
bptjm-67	182	2	a	a	PROPN
bptjm-67	182	3	,	,	PUNCT
bptjm-67	182	4	mcguire	mcguire	PROPN
bptjm-67	182	5	pg	pg	PROPN
bptjm-67	182	6	.	.	PUNCT
bptjm-67	182	7	retinal	retinal	ADJ
bptjm-67	182	8	and	and	CCONJ
bptjm-67	182	9	choroidal	choroidal	ADJ
bptjm-67	182	10	angiogenesis	angiogenesis	NOUN
bptjm-67	182	11	:	:	PUNCT
bptjm-67	182	12	pathophysiology	pathophysiology	NOUN
bptjm-67	182	13	and	and	CCONJ
bptjm-67	182	14	strategies	strategy	NOUN
bptjm-67	182	15	for	for	ADP
bptjm-67	182	16	inhibition	inhibition	NOUN
bptjm-67	182	17	.	.	PUNCT
bptjm-67	183	1	prog	prog	PROPN
bptjm-67	183	2	retin	retin	PROPN
bptjm-67	183	3	eye	eye	PROPN
bptjm-67	183	4	res	re	NOUN
bptjm-67	183	5	.	.	PUNCT
bptjm-67	184	1	2003;22(6):721–748	2003;22(6):721–748	X
bptjm-67	184	2	.	.	PUNCT
bptjm-67	184	3	doi:10.1016	doi:10.1016	PROPN
bptjm-67	184	4	/	/	SYM
bptjm-67	184	5	j.preteyeres.2003.08.001	j.preteyeres.2003.08.001	PROPN
bptjm-67	184	6	9	9	NUM
bptjm-67	184	7	.	.	PUNCT
bptjm-67	185	1	stackhouse	stackhouse	PROPN
bptjm-67	185	2	tl	tl	PROPN
bptjm-67	185	3	,	,	PUNCT
bptjm-67	185	4	mishra	mishra	PROPN
bptjm-67	185	5	a.	a.	PROPN
bptjm-67	185	6	neurovascular	neurovascular	PROPN
bptjm-67	185	7	coupling	couple	VERB
bptjm-67	185	8	in	in	ADP
bptjm-67	185	9	development	development	NOUN
bptjm-67	185	10	and	and	CCONJ
bptjm-67	185	11	disease	disease	NOUN
bptjm-67	185	12	:	:	PUNCT
bptjm-67	185	13	focus	focus	VERB
bptjm-67	185	14	on	on	ADP
bptjm-67	185	15	astrocytes	astrocyte	NOUN
bptjm-67	185	16	.	.	PUNCT
bptjm-67	186	1	front	front	ADJ
bptjm-67	186	2	cell	cell	NOUN
bptjm-67	186	3	dev	dev	PROPN
bptjm-67	186	4	biol	biol	NOUN
bptjm-67	186	5	.	.	PUNCT
bptjm-67	187	1	2021;9:702832	2021;9:702832	NOUN
bptjm-67	187	2	.	.	PUNCT
bptjm-67	188	1	doi:10.3389	doi:10.3389	PROPN
bptjm-67	188	2	/	/	SYM
bptjm-67	188	3	fcell.2021.702832	fcell.2021.702832	PROPN
bptjm-67	188	4	10	10	NUM
bptjm-67	188	5	.	.	PUNCT
bptjm-67	189	1	shabir	shabir	PROPN
bptjm-67	189	2	o	o	PROPN
bptjm-67	189	3	,	,	PUNCT
bptjm-67	189	4	berwick	berwick	PROPN
bptjm-67	189	5	j	j	PROPN
bptjm-67	189	6	,	,	PUNCT
bptjm-67	189	7	francis	francis	PROPN
bptjm-67	189	8	se	se	PROPN
bptjm-67	189	9	.	.	PUNCT
bptjm-67	190	1	neurovascular	neurovascular	ADJ
bptjm-67	190	2	dysfunction	dysfunction	NOUN
bptjm-67	190	3	in	in	ADP
bptjm-67	190	4	vascular	vascular	ADJ
bptjm-67	190	5	dementia	dementia	NOUN
bptjm-67	190	6	,	,	PUNCT
bptjm-67	190	7	alzheimer	alzheimer	PROPN
bptjm-67	190	8	's	's	PART
bptjm-67	190	9	and	and	CCONJ
bptjm-67	190	10	atherosclerosis	atherosclerosis	NOUN
bptjm-67	190	11	.	.	PUNCT
bptjm-67	191	1	bmc	bmc	PROPN
bptjm-67	191	2	neurosci	neurosci	PROPN
bptjm-67	191	3	.	.	PUNCT
bptjm-67	192	1	2018;19(1):62	2018;19(1):62	X
bptjm-67	192	2	.	.	PUNCT
bptjm-67	192	3	doi:10.1186	doi:10.1186	PROPN
bptjm-67	192	4	/	/	SYM
bptjm-67	192	5	s12868	s12868	ADJ
bptjm-67	192	6	-	-	PUNCT
bptjm-67	192	7	018	018	NUM
bptjm-67	192	8	-	-	PUNCT
bptjm-67	192	9	0465	0465	NUM
bptjm-67	192	10	-	-	SYM
bptjm-67	192	11	5	5	NUM
bptjm-67	192	12	11	11	NUM
bptjm-67	192	13	.	.	PUNCT
bptjm-67	193	1	sweeney	sweeney	PROPN
bptjm-67	193	2	m	m	PROPN
bptjm-67	193	3	,	,	PUNCT
bptjm-67	193	4	ayyadurai	ayyadurai	PROPN
bptjm-67	193	5	s	s	PROPN
bptjm-67	193	6	,	,	PUNCT
bptjm-67	193	7	zlokovic	zlokovic	PROPN
bptjm-67	193	8	b.	b.	PROPN
bptjm-67	193	9	pericytes	pericyte	NOUN
bptjm-67	193	10	of	of	ADP
bptjm-67	193	11	the	the	DET
bptjm-67	193	12	neurovascular	neurovascular	ADJ
bptjm-67	193	13	unit	unit	NOUN
bptjm-67	193	14	:	:	PUNCT
bptjm-67	193	15	key	key	ADJ
bptjm-67	193	16	functions	function	NOUN
bptjm-67	193	17	and	and	CCONJ
bptjm-67	193	18	signaling	signal	VERB
bptjm-67	193	19	pathways	pathway	NOUN
bptjm-67	193	20	.	.	PUNCT
bptjm-67	194	1	nat	nat	PROPN
bptjm-67	194	2	neurosci	neurosci	PROPN
bptjm-67	194	3	.	.	PUNCT
bptjm-67	195	1	2016;19:771–783	2016;19:771–783	NOUN
bptjm-67	195	2	.	.	PUNCT
bptjm-67	196	1	doi:10.1038	doi:10.1038	PROPN
bptjm-67	196	2	/	/	SYM
bptjm-67	196	3	nn.4288	nn.4288	PROPN
bptjm-67	196	4	12	12	NUM
bptjm-67	196	5	.	.	PUNCT
bptjm-67	197	1	kril	kril	PROPN
bptjm-67	197	2	jj	jj	PROPN
bptjm-67	197	3	,	,	PUNCT
bptjm-67	197	4	patel	patel	PROPN
bptjm-67	197	5	s	s	PROPN
bptjm-67	197	6	,	,	PUNCT
bptjm-67	197	7	harding	harding	PROPN
bptjm-67	197	8	aj	aj	PROPN
bptjm-67	197	9	,	,	PUNCT
bptjm-67	197	10	et	et	PROPN
bptjm-67	197	11	al	al	PROPN
bptjm-67	197	12	.	.	PUNCT
bptjm-67	198	1	patients	patient	NOUN
bptjm-67	198	2	with	with	ADP
bptjm-67	198	3	vascular	vascular	ADJ
bptjm-67	198	4	dementia	dementia	NOUN
bptjm-67	198	5	due	due	ADP
bptjm-67	198	6	to	to	ADP
bptjm-67	198	7	microvascular	microvascular	ADJ
bptjm-67	198	8	pathology	pathology	NOUN
bptjm-67	198	9	have	have	VERB
bptjm-67	198	10	significant	significant	ADJ
bptjm-67	198	11	hippocampal	hippocampal	ADJ
bptjm-67	198	12	neuronal	neuronal	ADJ
bptjm-67	198	13	loss	loss	NOUN
bptjm-67	198	14	.	.	PUNCT
bptjm-67	199	1	j	j	PROPN
bptjm-67	199	2	neurol	neurol	PROPN
bptjm-67	199	3	neurosurg	neurosurg	PROPN
bptjm-67	199	4	psychiatry	psychiatry	NOUN
bptjm-67	199	5	.	.	PUNCT
bptjm-67	200	1	2002;72:747–751	2002;72:747–751	NUM
bptjm-67	200	2	.	.	PUNCT
bptjm-67	201	1	13	13	NUM
bptjm-67	201	2	.	.	PUNCT
bptjm-67	202	1	wang	wang	PROPN
bptjm-67	202	2	s	s	PROPN
bptjm-67	202	3	,	,	PUNCT
bptjm-67	202	4	tang	tang	X
bptjm-67	202	5	c	c	X
bptjm-67	202	6	,	,	PUNCT
bptjm-67	202	7	liu	liu	PROPN
bptjm-67	202	8	y	y	PROPN
bptjm-67	202	9	,	,	PUNCT
bptjm-67	202	10	et	et	PROPN
bptjm-67	202	11	al	al	PROPN
bptjm-67	202	12	.	.	PROPN
bptjm-67	202	13	impact	impact	NOUN
bptjm-67	202	14	of	of	ADP
bptjm-67	202	15	impaired	impaired	ADJ
bptjm-67	202	16	cerebral	cerebral	ADJ
bptjm-67	202	17	blood	blood	NOUN
bptjm-67	202	18	flow	flow	NOUN
bptjm-67	202	19	autoregulation	autoregulation	NOUN
bptjm-67	202	20	on	on	ADP
bptjm-67	202	21	cognitive	cognitive	ADJ
bptjm-67	202	22	impairment	impairment	NOUN
bptjm-67	202	23	.	.	PUNCT
bptjm-67	203	1	front	front	ADJ
bptjm-67	203	2	aging	aging	NOUN
bptjm-67	203	3	.	.	PUNCT
bptjm-67	204	1	2022;3:1077302	2022;3:1077302	PROPN
bptjm-67	204	2	.	.	PUNCT
bptjm-67	204	3	doi:10.3389	doi:10.3389	PROPN
bptjm-67	204	4	/	/	SYM
bptjm-67	204	5	fragi.2022.1077302	fragi.2022.1077302	PROPN
bptjm-67	204	6	14	14	NUM
bptjm-67	204	7	.	.	PUNCT
bptjm-67	205	1	sienski	sienski	ADV
bptjm-67	205	2	g	g	PROPN
bptjm-67	205	3	,	,	PUNCT
bptjm-67	205	4	et	et	PROPN
bptjm-67	205	5	al	al	PROPN
bptjm-67	205	6	.	.	PUNCT
bptjm-67	206	1	apoe4	apoe4	PROPN
bptjm-67	206	2	disrupts	disrupt	VERB
bptjm-67	206	3	intracellular	intracellular	ADJ
bptjm-67	206	4	lipid	lipid	NOUN
bptjm-67	206	5	homeostasis	homeostasis	NOUN
bptjm-67	206	6	in	in	ADP
bptjm-67	206	7	human	human	ADJ
bptjm-67	206	8	ipsc	ipsc	NOUN
bptjm-67	206	9	-	-	PUNCT
bptjm-67	206	10	derived	derive	VERB
bptjm-67	206	11	glia	glia	NOUN
bptjm-67	206	12	.	.	PUNCT
bptjm-67	207	1	sci	sci	PROPN
bptjm-67	207	2	transl	transl	PROPN
bptjm-67	207	3	med	med	PROPN
bptjm-67	207	4	.	.	PUNCT
bptjm-67	208	1	2021;13(583):eaaz4564	2021;13(583):eaaz4564	NUM
bptjm-67	208	2	.	.	PUNCT
bptjm-67	208	3	doi:10.1126	doi:10.1126	PROPN
bptjm-67	208	4	/	/	SYM
bptjm-67	208	5	scitranslmed.aaz4564https://investor	scitranslmed.aaz4564https://investor	PROPN
bptjm-67	208	6	.jazzpharma.com	.jazzpharma.com	PROPN
bptjm-67	208	7	/	/	SYM
bptjm-67	208	8	news	news	NOUN
bptjm-67	208	9	-	-	PUNCT
bptjm-67	208	10	releases	release	NOUN
bptjm-67	208	11	/	/	SYM
bptjm-67	208	12	news	news	NOUN
bptjm-67	208	13	-	-	PUNCT
bptjm-67	208	14	release	release	NOUN
bptjm-67	208	15	-	-	PUNCT
bptjm-67	208	16	detail	detail	NOUN
bptjm-67	208	17	s	s	NOUN
bptjm-67	208	18	/	/	SYM
bptjm-67	208	19	jazz	jazz	NOUN
bptjm-67	208	20	-	-	PUNCT
bptjm-67	208	21	pharmaceuticals	pharmaceutical	NOUN
bptjm-67	208	22	-	-	PUNCT
bptjm-67	208	23	announces	announce	NOUN
bptjm-67	208	24	-	-	PUNCT
bptjm-67	208	25	fda	fda	PROPN
bptjm-67	208	26	-	-	PUNCT
bptjm-67	208	27	acceptanceberkeley	acceptanceberkeley	PROPN
bptjm-67	208	28	pharma	pharma	PROPN
bptjm-67	208	29	tech	tech	NOUN
bptjm-67	208	30	journal	journal	NOUN
bptjm-67	208	31	of	of	ADP
bptjm-67	208	32	medicine	medicine	NOUN
bptjm-67	209	1	|	|	ADV
bptjm-67	209	2	140	140	NUM
bptjm-67	209	3	new	new	ADJ
bptjm-67	209	4	-	-	PUNCT
bptjm-67	209	5	drug	drug	NOUN
bptjm-67	209	6	15	15	NUM
bptjm-67	209	7	.	.	PUNCT
bptjm-67	210	1	zlokovic	zlokovic	PROPN
bptjm-67	210	2	bv	bv	PROPN
bptjm-67	210	3	.	.	PROPN
bptjm-67	210	4	neurovascular	neurovascular	PROPN
bptjm-67	210	5	pathways	pathway	NOUN
bptjm-67	210	6	to	to	ADP
bptjm-67	210	7	neurodegeneration	neurodegeneration	NOUN
bptjm-67	210	8	in	in	ADP
bptjm-67	210	9	alzheimer	alzheimer	PROPN
bptjm-67	210	10	’s	’s	PART
bptjm-67	210	11	disease	disease	NOUN
bptjm-67	210	12	and	and	CCONJ
bptjm-67	210	13	other	other	ADJ
bptjm-67	210	14	disorders	disorder	NOUN
bptjm-67	210	15	.	.	PUNCT
bptjm-67	211	1	nat	nat	PROPN
bptjm-67	211	2	rev	rev	PROPN
bptjm-67	211	3	neurosci	neurosci	PROPN
bptjm-67	211	4	.	.	PUNCT
bptjm-67	212	1	2011;12:723–738	2011;12:723–738	NOUN
bptjm-67	212	2	.	.	PUNCT
bptjm-67	212	3	doi:10.1038	doi:10.1038	NOUN
bptjm-67	212	4	/	/	SYM
bptjm-67	212	5	nrn3114	nrn3114	NOUN
bptjm-67	212	6	16	16	NUM
bptjm-67	212	7	.	.	PUNCT
bptjm-67	213	1	nelson	nelson	PROPN
bptjm-67	213	2	ar	ar	PROPN
bptjm-67	213	3	,	,	PUNCT
bptjm-67	213	4	sweeney	sweeney	PROPN
bptjm-67	213	5	md	md	PROPN
bptjm-67	213	6	,	,	PUNCT
bptjm-67	213	7	sagare	sagare	PROPN
bptjm-67	213	8	ap	ap	PROPN
bptjm-67	213	9	,	,	PUNCT
bptjm-67	213	10	zlokovic	zlokovic	PROPN
bptjm-67	213	11	bv	bv	PROPN
bptjm-67	213	12	.	.	PROPN
bptjm-67	213	13	neurovascular	neurovascular	ADJ
bptjm-67	213	14	dysfunction	dysfunction	NOUN
bptjm-67	213	15	and	and	CCONJ
bptjm-67	213	16	neurodegeneration	neurodegeneration	NOUN
bptjm-67	213	17	in	in	ADP
bptjm-67	213	18	dementia	dementia	NOUN
bptjm-67	213	19	and	and	CCONJ
bptjm-67	213	20	alzheimer	alzheimer	PROPN
bptjm-67	213	21	’s	’s	PART
bptjm-67	213	22	disease	disease	NOUN
bptjm-67	213	23	.	.	PUNCT
bptjm-67	214	1	biochim	biochim	PROPN
bptjm-67	214	2	biophys	biophy	NOUN
bptjm-67	214	3	acta	acta	PROPN
bptjm-67	214	4	.	.	PUNCT
bptjm-67	215	1	2016;1862(5):887–900	2016;1862(5):887–900	X
bptjm-67	215	2	.	.	PUNCT
bptjm-67	215	3	doi:10.1016	doi:10.1016	PROPN
bptjm-67	215	4	/	/	SYM
bptjm-67	215	5	j.bbadis.2015.12.016	j.bbadis.2015.12.016	PROPN
bptjm-67	215	6	17	17	NUM
bptjm-67	215	7	.	.	PUNCT
bptjm-67	216	1	roy	roy	PROPN
bptjm-67	216	2	rk	rk	PROPN
bptjm-67	216	3	,	,	PUNCT
bptjm-67	216	4	althammer	althammer	PROPN
bptjm-67	216	5	f	f	PROPN
bptjm-67	216	6	,	,	PUNCT
bptjm-67	216	7	seymour	seymour	PROPN
bptjm-67	216	8	aj	aj	PROPN
bptjm-67	216	9	,	,	PUNCT
bptjm-67	216	10	et	et	PROPN
bptjm-67	216	11	al	al	PROPN
bptjm-67	216	12	.	.	PROPN
bptjm-67	216	13	inverse	inverse	PROPN
bptjm-67	216	14	neurovascular	neurovascular	PROPN
bptjm-67	216	15	coupling	coupling	NOUN
bptjm-67	216	16	contributes	contribute	VERB
bptjm-67	216	17	to	to	ADP
bptjm-67	216	18	positive	positive	ADJ
bptjm-67	216	19	feedback	feedback	NOUN
bptjm-67	216	20	excitation	excitation	NOUN
bptjm-67	216	21	of	of	ADP
bptjm-67	216	22	vasopressin	vasopressin	NOUN
bptjm-67	216	23	neurons	neuron	NOUN
bptjm-67	216	24	during	during	ADP
bptjm-67	216	25	a	a	DET
bptjm-67	216	26	systemic	systemic	ADJ
bptjm-67	216	27	homeostatic	homeostatic	ADJ
bptjm-67	216	28	challenge	challenge	NOUN
bptjm-67	216	29	.	.	PUNCT
bptjm-67	217	1	cell	cell	NOUN
bptjm-67	217	2	rep	rep	PROPN
bptjm-67	217	3	.	.	PROPN
bptjm-67	217	4	2021;37(5):109925	2021;37(5):109925	PROPN
bptjm-67	217	5	.	.	PUNCT
bptjm-67	217	6	doi:10.1016	doi:10.1016	PROPN
bptjm-67	217	7	/	/	SYM
bptjm-67	217	8	j.celrep.2021.109925	j.celrep.2021.109925	PROPN
bptjm-67	217	9	18	18	NUM
bptjm-67	217	10	.	.	PUNCT
bptjm-67	218	1	decroix	decroix	PROPN
bptjm-67	218	2	l	l	PROPN
bptjm-67	218	3	,	,	PUNCT
bptjm-67	218	4	van	van	PROPN
bptjm-67	218	5	schuerbeek	schuerbeek	NOUN
bptjm-67	218	6	p	p	X
bptjm-67	218	7	,	,	PUNCT
bptjm-67	218	8	tonoli	tonoli	PROPN
bptjm-67	218	9	c	c	PROPN
bptjm-67	218	10	,	,	PUNCT
bptjm-67	218	11	et	et	PROPN
bptjm-67	218	12	al	al	PROPN
bptjm-67	218	13	.	.	PUNCT
bptjm-67	219	1	the	the	DET
bptjm-67	219	2	effect	effect	NOUN
bptjm-67	219	3	of	of	ADP
bptjm-67	219	4	acute	acute	ADJ
bptjm-67	219	5	cocoa	cocoa	NOUN
bptjm-67	219	6	flavanol	flavanol	PROPN
bptjm-67	219	7	intake	intake	NOUN
bptjm-67	219	8	on	on	ADP
bptjm-67	219	9	the	the	DET
bptjm-67	219	10	bold	bold	ADJ
bptjm-67	219	11	response	response	NOUN
bptjm-67	219	12	and	and	CCONJ
bptjm-67	219	13	cognitive	cognitive	ADJ
bptjm-67	219	14	function	function	NOUN
bptjm-67	219	15	in	in	ADP
bptjm-67	219	16	type	type	NOUN
bptjm-67	219	17	1	1	NUM
bptjm-67	219	18	diabetes	diabetes	NOUN
bptjm-67	219	19	:	:	PUNCT
bptjm-67	219	20	a	a	DET
bptjm-67	219	21	randomized	randomized	ADJ
bptjm-67	219	22	,	,	PUNCT
bptjm-67	219	23	placebo	placebo	NOUN
bptjm-67	219	24	-	-	PUNCT
bptjm-67	219	25	controlled	control	VERB
bptjm-67	219	26	,	,	PUNCT
bptjm-67	219	27	double	double	ADJ
bptjm-67	219	28	-	-	PUNCT
bptjm-67	219	29	blinded	blind	VERB
bptjm-67	219	30	cross	cross	ADJ
bptjm-67	219	31	-	-	ADJ
bptjm-67	219	32	over	over	ADV
bptjm-67	219	33	pilot	pilot	NOUN
bptjm-67	219	34	study	study	NOUN
bptjm-67	219	35	.	.	PUNCT
bptjm-67	220	1	psychopharmacology	psychopharmacology	NOUN
bptjm-67	220	2	.	.	PUNCT
bptjm-67	221	1	2019;236(12):3421–3428	2019;236(12):3421–3428	NUM
bptjm-67	221	2	.	.	PUNCT
bptjm-67	221	3	doi:10.1007	doi:10.1007	NOUN
bptjm-67	221	4	/	/	SYM
bptjm-67	221	5	s00213	s00213	NOUN
bptjm-67	221	6	-	-	PUNCT
bptjm-67	221	7	019	019	NUM
bptjm-67	221	8	-	-	PUNCT
bptjm-67	221	9	05306	05306	NUM
bptjm-67	221	10	-	-	PUNCT
bptjm-67	221	11	z	z	NOUN
bptjm-67	221	12	19	19	NUM
bptjm-67	221	13	.	.	PUNCT
bptjm-67	221	14	hashimoto	hashimoto	PROPN
bptjm-67	221	15	y	y	PROPN
bptjm-67	221	16	,	,	PUNCT
bptjm-67	221	17	greene	greene	PROPN
bptjm-67	221	18	c	c	PROPN
bptjm-67	221	19	,	,	PUNCT
bptjm-67	221	20	munnich	munnich	PROPN
bptjm-67	221	21	a	a	X
bptjm-67	221	22	,	,	PUNCT
bptjm-67	221	23	campbell	campbell	PROPN
bptjm-67	221	24	m.	m.	NOUN
bptjm-67	221	25	the	the	DET
bptjm-67	221	26	cldn5	cldn5	NOUN
bptjm-67	221	27	gene	gene	NOUN
bptjm-67	221	28	at	at	ADP
bptjm-67	221	29	the	the	DET
bptjm-67	221	30	blood	blood	NOUN
bptjm-67	221	31	-	-	PUNCT
bptjm-67	221	32	brain	brain	NOUN
bptjm-67	221	33	barrier	barrier	NOUN
bptjm-67	221	34	in	in	ADP
bptjm-67	221	35	health	health	NOUN
bptjm-67	221	36	and	and	CCONJ
bptjm-67	221	37	disease	disease	NOUN
bptjm-67	221	38	.	.	PUNCT
bptjm-67	222	1	fluids	fluid	NOUN
bptjm-67	222	2	barriers	barrier	NOUN
bptjm-67	222	3	cns	cns	PROPN
bptjm-67	222	4	.	.	PUNCT
bptjm-67	223	1	2023;20(1):1	2023;20(1):1	NUM
bptjm-67	223	2	.	.	PUNCT
bptjm-67	224	1	doi:10.1186	doi:10.1186	PROPN
bptjm-67	224	2	/	/	SYM
bptjm-67	224	3	s12987	s12987	PROPN
bptjm-67	224	4	-	-	PUNCT
bptjm-67	224	5	023	023	NUM
bptjm-67	224	6	-	-	PUNCT
bptjm-67	224	7	00424	00424	NUM
bptjm-67	224	8	-	-	SYM
bptjm-67	224	9	5	5	NUM
bptjm-67	224	10	20	20	NUM
bptjm-67	224	11	.	.	PUNCT
bptjm-67	225	1	hwang	hwang	PROPN
bptjm-67	225	2	e	e	PROPN
bptjm-67	225	3	,	,	PUNCT
bptjm-67	225	4	song	song	NOUN
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bptjm-67	225	7	adverse	adverse	ADJ
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bptjm-67	225	10	high	high	ADJ
bptjm-67	225	11	-	-	PUNCT
bptjm-67	225	12	dose	dose	NOUN
bptjm-67	225	13	nicotinamide	nicotinamide	NOUN
bptjm-67	225	14	:	:	PUNCT
bptjm-67	225	15	mechanisms	mechanism	NOUN
bptjm-67	225	16	and	and	CCONJ
bptjm-67	225	17	safety	safety	NOUN
bptjm-67	225	18	assessment	assessment	NOUN
bptjm-67	225	19	.	.	PUNCT
bptjm-67	226	1	biomolecules	biomolecule	NOUN
bptjm-67	226	2	.	.	PUNCT
bptjm-67	227	1	2020;10(5):687	2020;10(5):687	NUM
bptjm-67	227	2	.	.	PUNCT
bptjm-67	228	1	doi:10.3390	doi:10.3390	NOUN
bptjm-67	228	2	/	/	SYM
bptjm-67	228	3	biom10050687	biom10050687	PROPN
bptjm-67	228	4	21	21	NUM
bptjm-67	228	5	.	.	PUNCT
bptjm-67	229	1	kotliar	kotliar	PROPN
bptjm-67	229	2	k	k	PROPN
bptjm-67	229	3	,	,	PUNCT
bptjm-67	229	4	hauser	hauser	PROPN
bptjm-67	229	5	c	c	PROPN
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bptjm-67	229	7	ortner	ortner	NOUN
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bptjm-67	229	9	,	,	PUNCT
bptjm-67	229	10	et	et	PROPN
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bptjm-67	229	15	coupling	coupling	NOUN
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bptjm-67	229	17	measured	measure	VERB
bptjm-67	229	18	by	by	ADP
bptjm-67	229	19	optical	optical	ADJ
bptjm-67	229	20	imaging	imaging	NOUN
bptjm-67	229	21	:	:	PUNCT
bptjm-67	229	22	a	a	DET
bptjm-67	229	23	biomarker	biomarker	NOUN
bptjm-67	229	24	for	for	ADP
bptjm-67	229	25	alzheimer	alzheimer	PROPN
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bptjm-67	229	27	disease	disease	NOUN
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bptjm-67	230	1	sci	sci	PROPN
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bptjm-67	230	5	.	.	PUNCT
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bptjm-67	231	2	/	/	SYM
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bptjm-67	231	7	13349	13349	NUM
bptjm-67	231	8	-	-	SYM
bptjm-67	231	9	5	5	NUM
bptjm-67	231	10	22	22	NUM
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bptjm-67	232	10	et	et	PROPN
bptjm-67	232	11	al	al	PROPN
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bptjm-67	232	15	ca2	ca2	PROPN
bptjm-67	232	16	+	+	PROPN
bptjm-67	232	17	responses	response	NOUN
bptjm-67	232	18	in	in	ADP
bptjm-67	232	19	neurovascular	neurovascular	ADJ
bptjm-67	232	20	coupling	coupling	NOUN
bptjm-67	232	21	during	during	ADP
bptjm-67	232	22	somatosensory	somatosensory	NOUN
bptjm-67	232	23	stimulation	stimulation	NOUN
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bptjm-67	232	25	for	for	ADP
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bptjm-67	232	28	state	state	NOUN
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bptjm-67	233	2	rep	rep	PROPN
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bptjm-67	233	5	.	.	PUNCT
bptjm-67	234	1	doi:10.1016	doi:10.1016	PROPN
bptjm-67	234	2	/	/	SYM
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bptjm-67	234	5	.	.	PUNCT
bptjm-67	235	1	clinicaltrials.gov	clinicaltrials.gov	X
bptjm-67	235	2	.	.	NOUN
bptjm-67	235	3	inorganic	inorganic	ADJ
bptjm-67	235	4	nitrate	nitrate	NOUN
bptjm-67	235	5	supplementation	supplementation	NOUN
bptjm-67	235	6	on	on	ADP
bptjm-67	235	7	cerebrovascular	cerebrovascular	ADJ
bptjm-67	235	8	aging	aging	NOUN
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bptjm-67	235	10	arterial	arterial	ADJ
bptjm-67	235	11	stiffness	stiffness	NOUN
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bptjm-67	235	13	.	.	PUNCT
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bptjm-67	236	2	april	april	PROPN
bptjm-67	236	3	26	26	NUM
bptjm-67	236	4	,	,	PUNCT
bptjm-67	236	5	2024	2024	NUM
bptjm-67	236	6	.	.	PUNCT
bptjm-67	237	1	https://clinicaltrials.gov/ct2/show/study/	https://clinicaltrials.gov/ct2/show/study/	ADJ
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bptjm-67	237	3	24	24	NUM
bptjm-67	237	4	.	.	PUNCT
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bptjm-67	238	2	.	.	PUNCT
bptjm-67	239	1	the	the	DET
bptjm-67	239	2	effect	effect	NOUN
bptjm-67	239	3	of	of	ADP
bptjm-67	239	4	nad	nad	ADJ
bptjm-67	239	5	supplementation	supplementation	NOUN
bptjm-67	239	6	on	on	ADP
bptjm-67	239	7	brain	brain	NOUN
bptjm-67	239	8	vascular	vascular	ADJ
bptjm-67	239	9	health	health	NOUN
bptjm-67	239	10	in	in	ADP
bptjm-67	239	11	aging	aging	NOUN
bptjm-67	239	12	.	.	PUNCT
bptjm-67	240	1	accessed	access	VERB
bptjm-67	240	2	april	april	PROPN
bptjm-67	240	3	26	26	NUM
bptjm-67	240	4	,	,	PUNCT
bptjm-67	240	5	2024	2024	NUM
bptjm-67	240	6	.	.	PUNCT
bptjm-67	241	1	https://clinicaltrials.gov/ct2/show/nct0548346	https://clinicaltrials.gov/ct2/show/nct0548346	NUM
bptjm-67	241	2	5	5	NUM
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bptjm-67	241	6	journal	journal	NOUN
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bptjm-67	241	8	medicine	medicine	NOUN
bptjm-67	241	9	|	|	ADV
bptjm-67	241	10	141	141	NUM
bptjm-67	241	11	copy	copy	NOUN
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bptjm-67	241	13	eu	eu	PROPN
bptjm-67	241	14	body	body	NOUN
bptjm-67	241	15	paragraph.docx.pdf	paragraph.docx.pdf	PROPN
bptjm-67	241	16	copy	copy	NOUN
bptjm-67	241	17	of	of	ADP
bptjm-67	241	18	eu	eu	PROPN
bptjm-67	241	19	et	et	PROPN
bptjm-67	241	20	al	al	PROPN
bptjm-67	241	21	reference	reference	NOUN
bptjm-67	241	22	page.pdf	page.pdf	X