id	sid	tid	token	lemma	pos
bptjm-71	1	1	the	the	DET
bptjm-71	1	2	role	role	NOUN
bptjm-71	1	3	of	of	ADP
bptjm-71	1	4	the	the	DET
bptjm-71	1	5	gut	gut	NOUN
bptjm-71	1	6	microbiome	microbiome	NOUN
bptjm-71	1	7	in	in	ADP
bptjm-71	1	8	neuromodulation	neuromodulation	NOUN
bptjm-71	1	9	therapies	therapy	NOUN
bptjm-71	1	10	as	as	ADP
bptjm-71	1	11	a	a	DET
bptjm-71	1	12	potential	potential	ADJ
bptjm-71	1	13	treatment	treatment	NOUN
bptjm-71	1	14	adjunct	adjunct	ADJ
bptjm-71	1	15	for	for	ADP
bptjm-71	1	16	multiple	multiple	ADJ
bptjm-71	1	17	sclerosis	sclerosis	NOUN
bptjm-71	1	18	berkeley	berkeley	PROPN
bptjm-71	1	19	pharma	pharma	PROPN
bptjm-71	1	20	tech	tech	NOUN
bptjm-71	1	21	journal	journal	NOUN
bptjm-71	1	22	of	of	ADP
bptjm-71	1	23	medicine	medicine	NOUN
bptjm-71	1	24	correspondence	correspondence	NOUN
bptjm-71	1	25	:	:	PUNCT
bptjm-71	1	26	gabybentolila5@gmail.com	gabybentolila5@gmail.com	X
bptjm-71	1	27	keywords	keyword	VERB
bptjm-71	1	28	:	:	PUNCT
bptjm-71	1	29	cellular	cellular	ADJ
bptjm-71	1	30	senescence	senescence	NOUN
bptjm-71	1	31	neurodegenerative	neurodegenerative	ADJ
bptjm-71	1	32	diseases	disease	NOUN
bptjm-71	1	33	neuroinflammation	neuroinflammation	NOUN
bptjm-71	1	34	sasps	sasp	NOUN
bptjm-71	1	35	(	(	PUNCT
bptjm-71	1	36	senescence	senescence	NOUN
bptjm-71	1	37	-	-	PUNCT
bptjm-71	1	38	associated	associate	VERB
bptjm-71	1	39	secretory	secretory	ADJ
bptjm-71	1	40	phenotypes	phenotype	NOUN
bptjm-71	1	41	)	)	PUNCT
bptjm-71	2	1	senolytics	senolytic	NOUN
bptjm-71	2	2	senomorphics	senomorphic	NOUN
bptjm-71	2	3	tau	tau	PROPN
bptjm-71	2	4	protein	protein	NOUN
bptjm-71	2	5	submitted	submit	VERB
bptjm-71	2	6	july	july	PROPN
bptjm-71	2	7	19	19	NUM
bptjm-71	2	8	,	,	PUNCT
bptjm-71	2	9	2024	2024	NUM
bptjm-71	2	10	accepted	accept	VERB
bptjm-71	2	11	august	august	PROPN
bptjm-71	2	12	19	19	NUM
bptjm-71	2	13	,	,	PUNCT
bptjm-71	2	14	2024	2024	NUM
bptjm-71	2	15	published	publish	VERB
bptjm-71	2	16	december	december	PROPN
bptjm-71	2	17	27	27	NUM
bptjm-71	2	18	,	,	PUNCT
bptjm-71	2	19	2024	2024	NUM
bptjm-71	2	20	full	full	ADJ
bptjm-71	2	21	open	open	ADJ
bptjm-71	2	22	access	access	NOUN
bptjm-71	2	23	creative	creative	ADJ
bptjm-71	2	24	commons	common	NOUN
bptjm-71	2	25	attribution	attribution	NOUN
bptjm-71	2	26	license	license	VERB
bptjm-71	3	1	4.0	4.0	NUM
bptjm-71	3	2	abstract	abstract	NOUN
bptjm-71	3	3	there	there	PRON
bptjm-71	3	4	is	be	VERB
bptjm-71	3	5	strong	strong	ADJ
bptjm-71	3	6	evidence	evidence	NOUN
bptjm-71	3	7	that	that	SCONJ
bptjm-71	3	8	cellular	cellular	ADJ
bptjm-71	3	9	senescence	senescence	NOUN
bptjm-71	3	10	is	be	AUX
bptjm-71	3	11	involved	involve	VERB
bptjm-71	3	12	in	in	ADP
bptjm-71	3	13	the	the	DET
bptjm-71	3	14	pathogenesis	pathogenesis	NOUN
bptjm-71	3	15	of	of	ADP
bptjm-71	3	16	neurodegenerative	neurodegenerative	ADJ
bptjm-71	3	17	diseases	disease	NOUN
bptjm-71	3	18	such	such	ADJ
bptjm-71	3	19	as	as	ADP
bptjm-71	3	20	alzheimer	alzheimer	PROPN
bptjm-71	3	21	’s	’s	PART
bptjm-71	3	22	and	and	CCONJ
bptjm-71	3	23	parkinson	parkinson	NOUN
bptjm-71	3	24	’s	’s	PART
bptjm-71	3	25	disease	disease	NOUN
bptjm-71	3	26	.	.	PUNCT
bptjm-71	4	1	presence	presence	NOUN
bptjm-71	4	2	of	of	ADP
bptjm-71	4	3	abnormal	abnormal	ADJ
bptjm-71	4	4	tau	tau	PROPN
bptjm-71	4	5	protein	protein	NOUN
bptjm-71	4	6	in	in	ADP
bptjm-71	4	7	mouse	mouse	NOUN
bptjm-71	4	8	models	model	NOUN
bptjm-71	4	9	is	be	AUX
bptjm-71	4	10	implicated	implicate	VERB
bptjm-71	4	11	in	in	ADP
bptjm-71	4	12	senescence	senescence	NOUN
bptjm-71	4	13	phenotypes	phenotype	NOUN
bptjm-71	4	14	leading	lead	VERB
bptjm-71	4	15	to	to	ADP
bptjm-71	4	16	cognitive	cognitive	ADJ
bptjm-71	4	17	decline	decline	NOUN
bptjm-71	4	18	,	,	PUNCT
bptjm-71	4	19	while	while	SCONJ
bptjm-71	4	20	the	the	DET
bptjm-71	4	21	significance	significance	NOUN
bptjm-71	4	22	of	of	ADP
bptjm-71	4	23	pro	pro	ADJ
bptjm-71	4	24	-	-	ADJ
bptjm-71	4	25	inflammatory	inflammatory	ADJ
bptjm-71	4	26	molecules	molecule	NOUN
bptjm-71	4	27	called	call	VERB
bptjm-71	4	28	senescence	senescence	NOUN
bptjm-71	4	29	-	-	PUNCT
bptjm-71	4	30	associated	associate	VERB
bptjm-71	4	31	secretory	secretory	ADJ
bptjm-71	4	32	phenotypes	phenotype	NOUN
bptjm-71	4	33	(	(	PUNCT
bptjm-71	4	34	sasps	sasps	NOUN
bptjm-71	4	35	)	)	PUNCT
bptjm-71	4	36	in	in	ADP
bptjm-71	4	37	inflammation	inflammation	NOUN
bptjm-71	4	38	and	and	CCONJ
bptjm-71	4	39	degeneration	degeneration	NOUN
bptjm-71	4	40	highlights	highlight	VERB
bptjm-71	4	41	its	its	PRON
bptjm-71	4	42	potential	potential	ADJ
bptjm-71	4	43	importance	importance	NOUN
bptjm-71	4	44	in	in	ADP
bptjm-71	4	45	disease	disease	NOUN
bptjm-71	4	46	treatment	treatment	NOUN
bptjm-71	4	47	.	.	PUNCT
bptjm-71	5	1	understanding	understand	VERB
bptjm-71	5	2	the	the	DET
bptjm-71	5	3	involvement	involvement	NOUN
bptjm-71	5	4	of	of	ADP
bptjm-71	5	5	senescence	senescence	NOUN
bptjm-71	5	6	in	in	ADP
bptjm-71	5	7	disease	disease	NOUN
bptjm-71	5	8	progression	progression	NOUN
bptjm-71	5	9	is	be	AUX
bptjm-71	5	10	vital	vital	ADJ
bptjm-71	5	11	to	to	PART
bptjm-71	5	12	develop	develop	VERB
bptjm-71	5	13	effective	effective	ADJ
bptjm-71	5	14	treatment	treatment	NOUN
bptjm-71	5	15	strategies	strategy	NOUN
bptjm-71	5	16	.	.	PUNCT
bptjm-71	6	1	clearance	clearance	NOUN
bptjm-71	6	2	of	of	ADP
bptjm-71	6	3	such	such	ADJ
bptjm-71	6	4	cells	cell	NOUN
bptjm-71	6	5	can	can	AUX
bptjm-71	6	6	be	be	AUX
bptjm-71	6	7	performed	perform	VERB
bptjm-71	6	8	through	through	ADP
bptjm-71	6	9	senolytics	senolytic	NOUN
bptjm-71	6	10	drugs	drug	NOUN
bptjm-71	6	11	that	that	PRON
bptjm-71	6	12	disturb	disturb	VERB
bptjm-71	6	13	non	non	ADJ
bptjm-71	6	14	-	-	ADJ
bptjm-71	6	15	apoptosis	apoptosis	ADJ
bptjm-71	6	16	pathways	pathway	NOUN
bptjm-71	6	17	.	.	PUNCT
bptjm-71	7	1	alternatively	alternatively	ADV
bptjm-71	7	2	,	,	PUNCT
bptjm-71	7	3	senomorphics	senomorphic	NOUN
bptjm-71	7	4	involve	involve	VERB
bptjm-71	7	5	the	the	DET
bptjm-71	7	6	suppression	suppression	NOUN
bptjm-71	7	7	of	of	ADP
bptjm-71	7	8	senescence	senescence	NOUN
bptjm-71	7	9	burden	burden	NOUN
bptjm-71	7	10	,	,	PUNCT
bptjm-71	7	11	rather	rather	ADV
bptjm-71	7	12	than	than	ADP
bptjm-71	7	13	elimination	elimination	NOUN
bptjm-71	7	14	through	through	ADP
bptjm-71	7	15	apoptosis	apoptosis	NOUN
bptjm-71	7	16	,	,	PUNCT
bptjm-71	7	17	through	through	ADP
bptjm-71	7	18	the	the	DET
bptjm-71	7	19	intervention	intervention	NOUN
bptjm-71	7	20	of	of	ADP
bptjm-71	7	21	sasp	sasp	NOUN
bptjm-71	7	22	factors	factor	NOUN
bptjm-71	7	23	that	that	PRON
bptjm-71	7	24	elicit	elicit	VERB
bptjm-71	7	25	neuroinflammation	neuroinflammation	NOUN
bptjm-71	7	26	and	and	CCONJ
bptjm-71	7	27	tau	tau	PROPN
bptjm-71	7	28	toxicity	toxicity	NOUN
bptjm-71	7	29	.	.	PUNCT
bptjm-71	8	1	other	other	ADJ
bptjm-71	8	2	therapeutic	therapeutic	ADJ
bptjm-71	8	3	approaches	approach	NOUN
bptjm-71	8	4	involve	involve	VERB
bptjm-71	8	5	targeting	target	VERB
bptjm-71	8	6	mitochondrial	mitochondrial	ADJ
bptjm-71	8	7	dysfunction	dysfunction	NOUN
bptjm-71	8	8	to	to	PART
bptjm-71	8	9	attenuate	attenuate	VERB
bptjm-71	8	10	neuroinflammation	neuroinflammation	NOUN
bptjm-71	8	11	and	and	CCONJ
bptjm-71	8	12	senescence	senescence	NOUN
bptjm-71	8	13	stressors	stressor	NOUN
bptjm-71	8	14	,	,	PUNCT
bptjm-71	8	15	thereby	thereby	ADV
bptjm-71	8	16	preventing	prevent	VERB
bptjm-71	8	17	the	the	DET
bptjm-71	8	18	formation	formation	NOUN
bptjm-71	8	19	of	of	ADP
bptjm-71	8	20	a	a	DET
bptjm-71	8	21	feedback	feedback	NOUN
bptjm-71	8	22	loop	loop	NOUN
bptjm-71	8	23	.	.	PUNCT
bptjm-71	9	1	this	this	DET
bptjm-71	9	2	review	review	NOUN
bptjm-71	9	3	offers	offer	VERB
bptjm-71	9	4	insights	insight	NOUN
bptjm-71	9	5	into	into	ADP
bptjm-71	9	6	the	the	DET
bptjm-71	9	7	mechanisms	mechanism	NOUN
bptjm-71	9	8	of	of	ADP
bptjm-71	9	9	neuro	neuro	NOUN
bptjm-71	9	10	-	-	PUNCT
bptjm-71	9	11	degeneration	degeneration	NOUN
bptjm-71	9	12	driven	drive	VERB
bptjm-71	9	13	by	by	ADP
bptjm-71	9	14	cellular	cellular	ADJ
bptjm-71	9	15	senescence	senescence	NOUN
bptjm-71	9	16	in	in	ADP
bptjm-71	9	17	the	the	DET
bptjm-71	9	18	brain	brain	NOUN
bptjm-71	9	19	and	and	CCONJ
bptjm-71	9	20	outlines	outline	VERB
bptjm-71	9	21	novel	novel	ADJ
bptjm-71	9	22	therapeutic	therapeutic	ADJ
bptjm-71	9	23	strategies	strategy	NOUN
bptjm-71	9	24	to	to	PART
bptjm-71	9	25	reduce	reduce	VERB
bptjm-71	9	26	the	the	DET
bptjm-71	9	27	senescence	senescence	NOUN
bptjm-71	9	28	burden	burden	NOUN
bptjm-71	9	29	and	and	CCONJ
bptjm-71	9	30	slow	slow	ADJ
bptjm-71	9	31	disease	disease	NOUN
bptjm-71	9	32	progression	progression	NOUN
bptjm-71	9	33	.	.	PUNCT
bptjm-71	10	1	exploring	explore	VERB
bptjm-71	10	2	the	the	DET
bptjm-71	10	3	role	role	NOUN
bptjm-71	10	4	of	of	ADP
bptjm-71	10	5	senescent	senescent	ADJ
bptjm-71	10	6	cells	cell	NOUN
bptjm-71	10	7	in	in	ADP
bptjm-71	10	8	neurodegenerative	neurodegenerative	ADJ
bptjm-71	10	9	pathology	pathology	NOUN
bptjm-71	10	10	:	:	PUNCT
bptjm-71	10	11	a	a	DET
bptjm-71	10	12	window	window	NOUN
bptjm-71	10	13	into	into	ADP
bptjm-71	10	14	promising	promise	VERB
bptjm-71	10	15	therapeutic	therapeutic	ADJ
bptjm-71	10	16	avenues	avenue	NOUN
bptjm-71	10	17	by	by	ADP
bptjm-71	10	18	:	:	PUNCT
bptjm-71	10	19	gabriela	gabriela	PROPN
bptjm-71	10	20	bentolila	bentolila	PROPN
bptjm-71	10	21	,	,	PUNCT
bptjm-71	10	22	niharika	niharika	PROPN
bptjm-71	10	23	agrawal	agrawal	PROPN
bptjm-71	10	24	,	,	PUNCT
bptjm-71	10	25	julie	julie	PROPN
bptjm-71	10	26	phung	phung	PROPN
bptjm-71	10	27	,	,	PUNCT
bptjm-71	10	28	linh	linh	PROPN
bptjm-71	10	29	van	van	NOUN
bptjm-71	10	30	,	,	PUNCT
bptjm-71	10	31	and	and	CCONJ
bptjm-71	10	32	gatik	gatik	PROPN
bptjm-71	10	33	trivedi	trivedi	PROPN
bptjm-71	10	34	1	1	NUM
bptjm-71	10	35	.	.	PUNCT
bptjm-71	11	1	introduction	introduction	NOUN
bptjm-71	11	2	cellular	cellular	ADJ
bptjm-71	11	3	senescence	senescence	NOUN
bptjm-71	11	4	is	be	AUX
bptjm-71	11	5	a	a	DET
bptjm-71	11	6	state	state	NOUN
bptjm-71	11	7	of	of	ADP
bptjm-71	11	8	irreversible	irreversible	ADJ
bptjm-71	11	9	growth	growth	NOUN
bptjm-71	11	10	arrest	arrest	NOUN
bptjm-71	11	11	in	in	ADP
bptjm-71	11	12	cells	cell	NOUN
bptjm-71	11	13	that	that	PRON
bptjm-71	11	14	have	have	AUX
bptjm-71	11	15	aged	age	VERB
bptjm-71	11	16	and	and	CCONJ
bptjm-71	11	17	ceased	cease	VERB
bptjm-71	11	18	their	their	PRON
bptjm-71	11	19	ability	ability	NOUN
bptjm-71	11	20	to	to	PART
bptjm-71	11	21	multiply	multiply	VERB
bptjm-71	11	22	,	,	PUNCT
bptjm-71	11	23	yet	yet	CCONJ
bptjm-71	11	24	they	they	PRON
bptjm-71	11	25	avoid	avoid	VERB
bptjm-71	11	26	undergoing	undergo	VERB
bptjm-71	11	27	apoptosis	apoptosis	NOUN
bptjm-71	11	28	.	.	PUNCT
bptjm-71	12	1	this	this	DET
bptjm-71	12	2	process	process	NOUN
bptjm-71	12	3	is	be	AUX
bptjm-71	12	4	triggered	trigger	VERB
bptjm-71	12	5	in	in	ADP
bptjm-71	12	6	response	response	NOUN
bptjm-71	12	7	to	to	ADP
bptjm-71	12	8	various	various	ADJ
bptjm-71	12	9	stressors	stressor	NOUN
bptjm-71	12	10	such	such	ADJ
bptjm-71	12	11	as	as	ADP
bptjm-71	12	12	dna	dna	PROPN
bptjm-71	12	13	damage	damage	NOUN
bptjm-71	12	14	,	,	PUNCT
bptjm-71	12	15	telomere	telomere	NOUN
bptjm-71	12	16	shortening	shortening	NOUN
bptjm-71	12	17	,	,	PUNCT
bptjm-71	12	18	mitochondrial	mitochondrial	ADJ
bptjm-71	12	19	dysfunction	dysfunction	NOUN
bptjm-71	12	20	,	,	PUNCT
bptjm-71	12	21	tumor	tumor	NOUN
bptjm-71	12	22	suppression	suppression	NOUN
bptjm-71	12	23	,	,	PUNCT
bptjm-71	12	24	oxidative	oxidative	ADJ
bptjm-71	12	25	stress	stress	NOUN
bptjm-71	12	26	,	,	PUNCT
bptjm-71	12	27	and	and	CCONJ
bptjm-71	12	28	ionizing	ionize	VERB
bptjm-71	12	29	radiation	radiation	NOUN
bptjm-71	12	30	(	(	PUNCT
bptjm-71	12	31	fig	fig	NOUN
bptjm-71	12	32	.	.	PUNCT
bptjm-71	13	1	1a	1a	NOUN
bptjm-71	13	2	)	)	PUNCT
bptjm-71	13	3	.	.	PUNCT
bptjm-71	14	1	while	while	SCONJ
bptjm-71	14	2	senescence	senescence	NOUN
bptjm-71	14	3	plays	play	VERB
bptjm-71	14	4	a	a	DET
bptjm-71	14	5	protective	protective	ADJ
bptjm-71	14	6	role	role	NOUN
bptjm-71	14	7	in	in	ADP
bptjm-71	14	8	development	development	NOUN
bptjm-71	14	9	,	,	PUNCT
bptjm-71	14	10	aiding	aid	VERB
bptjm-71	14	11	in	in	ADP
bptjm-71	14	12	wound	wound	NOUN
bptjm-71	14	13	healing	healing	NOUN
bptjm-71	14	14	and	and	CCONJ
bptjm-71	14	15	limiting	limit	VERB
bptjm-71	14	16	tumor	tumor	NOUN
bptjm-71	14	17	progression	progression	NOUN
bptjm-71	14	18	,	,	PUNCT
bptjm-71	14	19	its	its	PRON
bptjm-71	14	20	accumulation	accumulation	NOUN
bptjm-71	14	21	also	also	ADV
bptjm-71	14	22	leads	lead	VERB
bptjm-71	14	23	to	to	ADP
bptjm-71	14	24	harmful	harmful	ADJ
bptjm-71	14	25	effects	effect	NOUN
bptjm-71	14	26	associated	associate	VERB
bptjm-71	14	27	with	with	ADP
bptjm-71	14	28	aging	age	VERB
bptjm-71	14	29	and	and	CCONJ
bptjm-71	14	30	age	age	NOUN
bptjm-71	14	31	-	-	PUNCT
bptjm-71	14	32	related	relate	VERB
bptjm-71	14	33	diseases	disease	NOUN
bptjm-71	14	34	.	.	PUNCT
bptjm-71	15	1	the	the	DET
bptjm-71	15	2	harmful	harmful	ADJ
bptjm-71	15	3	impact	impact	NOUN
bptjm-71	15	4	of	of	ADP
bptjm-71	15	5	senescence	senescence	NOUN
bptjm-71	15	6	is	be	AUX
bptjm-71	15	7	mainly	mainly	ADV
bptjm-71	15	8	attributed	attribute	VERB
bptjm-71	15	9	to	to	ADP
bptjm-71	15	10	the	the	DET
bptjm-71	15	11	release	release	NOUN
bptjm-71	15	12	of	of	ADP
bptjm-71	15	13	sasps	sasp	NOUN
bptjm-71	15	14	.	.	PUNCT
bptjm-71	16	1	research	research	NOUN
bptjm-71	16	2	comparing	compare	VERB
bptjm-71	16	3	biomarkers	biomarker	NOUN
bptjm-71	16	4	of	of	ADP
bptjm-71	16	5	senescence	senescence	NOUN
bptjm-71	16	6	in	in	ADP
bptjm-71	16	7	young	young	ADJ
bptjm-71	16	8	and	and	CCONJ
bptjm-71	16	9	aged	aged	ADJ
bptjm-71	16	10	mouse	mouse	NOUN
bptjm-71	16	11	brains	brain	NOUN
bptjm-71	16	12	has	have	AUX
bptjm-71	16	13	shown	show	VERB
bptjm-71	16	14	that	that	SCONJ
bptjm-71	16	15	senescent	senescent	ADJ
bptjm-71	16	16	cells	cell	NOUN
bptjm-71	16	17	increase	increase	VERB
bptjm-71	16	18	with	with	ADP
bptjm-71	16	19	age	age	NOUN
bptjm-71	16	20	,	,	PUNCT
bptjm-71	16	21	along	along	ADP
bptjm-71	16	22	with	with	ADP
bptjm-71	16	23	a	a	DET
bptjm-71	16	24	rise	rise	NOUN
bptjm-71	16	25	in	in	ADP
bptjm-71	16	26	sasp	sasp	NOUN
bptjm-71	16	27	factor	factor	NOUN
bptjm-71	16	28	genes.1	genes.1	PROPN
bptjm-71	16	29	consequently	consequently	ADV
bptjm-71	16	30	,	,	PUNCT
bptjm-71	16	31	this	this	PRON
bptjm-71	16	32	contributes	contribute	VERB
bptjm-71	16	33	to	to	PART
bptjm-71	16	34	decreased	decrease	VERB
bptjm-71	16	35	tissue	tissue	NOUN
bptjm-71	16	36	regeneration	regeneration	NOUN
bptjm-71	16	37	and	and	CCONJ
bptjm-71	16	38	increased	increase	VERB
bptjm-71	16	39	neuroinflammation	neuroinflammation	NOUN
bptjm-71	16	40	,	,	PUNCT
bptjm-71	16	41	paving	pave	VERB
bptjm-71	16	42	the	the	DET
bptjm-71	16	43	way	way	NOUN
bptjm-71	16	44	for	for	ADP
bptjm-71	16	45	neurodegenerative	neurodegenerative	ADJ
bptjm-71	16	46	diseases	disease	NOUN
bptjm-71	16	47	like	like	ADP
bptjm-71	16	48	alzheimer	alzheimer	PROPN
bptjm-71	16	49	's	's	PART
bptjm-71	16	50	disease	disease	NOUN
bptjm-71	16	51	(	(	PUNCT
bptjm-71	16	52	ad	ad	NOUN
bptjm-71	16	53	)	)	PUNCT
bptjm-71	16	54	,	,	PUNCT
bptjm-71	16	55	parkinson	parkinson	NOUN
bptjm-71	16	56	's	's	PART
bptjm-71	16	57	,	,	PUNCT
bptjm-71	16	58	and	and	CCONJ
bptjm-71	16	59	multiple	multiple	ADJ
bptjm-71	16	60	sclerosis	sclerosis	NOUN
bptjm-71	16	61	.	.	PUNCT
bptjm-71	17	1	furthermore	furthermore	ADV
bptjm-71	17	2	,	,	PUNCT
bptjm-71	17	3	gene	gene	NOUN
bptjm-71	17	4	ontology	ontology	NOUN
bptjm-71	17	5	analysis	analysis	NOUN
bptjm-71	17	6	has	have	AUX
bptjm-71	17	7	revealed	reveal	VERB
bptjm-71	17	8	a	a	DET
bptjm-71	17	9	strong	strong	ADJ
bptjm-71	17	10	connection	connection	NOUN
bptjm-71	17	11	between	between	ADP
bptjm-71	17	12	senescence	senescence	NOUN
bptjm-71	17	13	-	-	PUNCT
bptjm-71	17	14	related	relate	VERB
bptjm-71	17	15	genes	gene	NOUN
bptjm-71	17	16	,	,	PUNCT
bptjm-71	17	17	mild	mild	ADJ
bptjm-71	17	18	cognitive	cognitive	ADJ
bptjm-71	17	19	impairment	impairment	NOUN
bptjm-71	17	20	,	,	PUNCT
bptjm-71	17	21	and	and	CCONJ
bptjm-71	17	22	neurodegenerative	neurodegenerative	ADJ
bptjm-71	17	23	diseases.2	diseases.2	NOUN
bptjm-71	17	24	treating	treat	VERB
bptjm-71	17	25	senescence	senescence	NOUN
bptjm-71	17	26	has	have	AUX
bptjm-71	17	27	shown	show	VERB
bptjm-71	17	28	promise	promise	NOUN
bptjm-71	17	29	in	in	ADP
bptjm-71	17	30	improving	improve	VERB
bptjm-71	17	31	cognitive	cognitive	ADJ
bptjm-71	17	32	function	function	NOUN
bptjm-71	17	33	among	among	ADP
bptjm-71	17	34	patients	patient	NOUN
bptjm-71	17	35	with	with	ADP
bptjm-71	17	36	neurodegenerative	neurodegenerative	ADJ
bptjm-71	17	37	diseases	disease	NOUN
bptjm-71	17	38	.	.	PUNCT
bptjm-71	18	1	glial	glial	ADJ
bptjm-71	18	2	cells	cell	NOUN
bptjm-71	18	3	are	be	AUX
bptjm-71	18	4	the	the	DET
bptjm-71	18	5	primary	primary	ADJ
bptjm-71	18	6	cell	cell	NOUN
bptjm-71	18	7	type	type	NOUN
bptjm-71	18	8	in	in	ADP
bptjm-71	18	9	the	the	DET
bptjm-71	18	10	brain	brain	NOUN
bptjm-71	18	11	undergoing	undergo	VERB
bptjm-71	18	12	senescence	senescence	NOUN
bptjm-71	18	13	,	,	PUNCT
bptjm-71	18	14	contributing	contribute	VERB
bptjm-71	18	15	to	to	ADP
bptjm-71	18	16	neurodegenerative	neurodegenerative	ADJ
bptjm-71	18	17	diseases.3	diseases.3	PROPN
bptjm-71	18	18	glial	glial	ADJ
bptjm-71	18	19	cells	cell	NOUN
bptjm-71	18	20	play	play	VERB
bptjm-71	18	21	a	a	DET
bptjm-71	18	22	supportive	supportive	ADJ
bptjm-71	18	23	role	role	NOUN
bptjm-71	18	24	in	in	ADP
bptjm-71	18	25	maintaining	maintain	VERB
bptjm-71	18	26	neuronal	neuronal	ADJ
bptjm-71	18	27	functions	function	NOUN
bptjm-71	18	28	,	,	PUNCT
bptjm-71	18	29	and	and	CCONJ
bptjm-71	18	30	when	when	SCONJ
bptjm-71	18	31	compromised	compromise	VERB
bptjm-71	18	32	through	through	ADP
bptjm-71	18	33	senescence	senescence	NOUN
bptjm-71	18	34	,	,	PUNCT
bptjm-71	18	35	they	they	PRON
bptjm-71	18	36	trigger	trigger	VERB
bptjm-71	18	37	sasp	sasp	NOUN
bptjm-71	18	38	production	production	NOUN
bptjm-71	18	39	,	,	PUNCT
bptjm-71	18	40	neurotoxicity	neurotoxicity	NOUN
bptjm-71	18	41	,	,	PUNCT
bptjm-71	18	42	and	and	CCONJ
bptjm-71	18	43	neuroinflammation	neuroinflammation	NOUN
bptjm-71	18	44	—	—	PUNCT
bptjm-71	18	45	common	common	ADJ
bptjm-71	18	46	characteristics	characteristic	NOUN
bptjm-71	18	47	of	of	ADP
bptjm-71	18	48	neurodegenerative	neurodegenerative	ADJ
bptjm-71	18	49	diseases.4	diseases.4	PROPN
bptjm-71	18	50	astrocytes	astrocyte	NOUN
bptjm-71	18	51	,	,	PUNCT
bptjm-71	18	52	which	which	PRON
bptjm-71	18	53	are	be	AUX
bptjm-71	18	54	abundant	abundant	ADJ
bptjm-71	18	55	in	in	ADP
bptjm-71	18	56	the	the	DET
bptjm-71	18	57	brain	brain	NOUN
bptjm-71	18	58	and	and	CCONJ
bptjm-71	18	59	regulate	regulate	VERB
bptjm-71	18	60	synaptic	synaptic	ADJ
bptjm-71	18	61	signaling	signaling	NOUN
bptjm-71	18	62	,	,	PUNCT
bptjm-71	18	63	neurotrophic	neurotrophic	ADJ
bptjm-71	18	64	support	support	NOUN
bptjm-71	18	65	,	,	PUNCT
bptjm-71	18	66	and	and	CCONJ
bptjm-71	18	67	glutamate	glutamate	VERB
bptjm-71	18	68	metabolism	metabolism	NOUN
bptjm-71	18	69	,	,	PUNCT
bptjm-71	18	70	have	have	AUX
bptjm-71	18	71	been	be	AUX
bptjm-71	18	72	found	find	VERB
bptjm-71	18	73	to	to	PART
bptjm-71	18	74	be	be	AUX
bptjm-71	18	75	affected	affect	VERB
bptjm-71	18	76	by	by	ADP
bptjm-71	18	77	senescence	senescence	NOUN
bptjm-71	18	78	.	.	PUNCT
bptjm-71	19	1	likewise	likewise	ADV
bptjm-71	19	2	,	,	PUNCT
bptjm-71	19	3	microglia	microglia	ADJ
bptjm-71	19	4	,	,	PUNCT
bptjm-71	19	5	essential	essential	ADJ
bptjm-71	19	6	for	for	ADP
bptjm-71	19	7	cns	cns	NOUN
bptjm-71	19	8	homeostasis	homeostasis	NOUN
bptjm-71	19	9	,	,	PUNCT
bptjm-71	19	10	experience	experience	NOUN
bptjm-71	19	11	senescence	senescence	NOUN
bptjm-71	19	12	during	during	ADP
bptjm-71	19	13	aging	age	VERB
bptjm-71	19	14	and	and	CCONJ
bptjm-71	19	15	are	be	AUX
bptjm-71	19	16	associated	associate	VERB
bptjm-71	19	17	with	with	ADP
bptjm-71	19	18	neuroinflammatory	neuroinflammatory	ADJ
bptjm-71	19	19	phenotypes	phenotype	NOUN
bptjm-71	19	20	and	and	CCONJ
bptjm-71	19	21	neural	neural	ADJ
bptjm-71	19	22	impairment	impairment	NOUN
bptjm-71	19	23	when	when	SCONJ
bptjm-71	19	24	increased	increase	VERB
bptjm-71	19	25	in	in	ADP
bptjm-71	19	26	number.1	number.1	NOUN
bptjm-71	19	27	moreover	moreover	ADV
bptjm-71	19	28	,	,	PUNCT
bptjm-71	19	29	oligodendrocytes	oligodendrocyte	NOUN
bptjm-71	19	30	(	(	PUNCT
bptjm-71	19	31	olg	olg	NOUN
bptjm-71	19	32	)	)	PUNCT
bptjm-71	19	33	,	,	PUNCT
bptjm-71	19	34	derived	derive	VERB
bptjm-71	19	35	from	from	ADP
bptjm-71	19	36	oligodendrocyte	oligodendrocyte	ADJ
bptjm-71	19	37	progenitor	progenitor	NOUN
bptjm-71	19	38	cells	cell	NOUN
bptjm-71	19	39	(	(	PUNCT
bptjm-71	19	40	opcs	opcs	PROPN
bptjm-71	19	41	)	)	PUNCT
bptjm-71	19	42	,	,	PUNCT
bptjm-71	19	43	are	be	AUX
bptjm-71	19	44	involved	involve	VERB
bptjm-71	19	45	in	in	ADP
bptjm-71	19	46	responding	respond	VERB
bptjm-71	19	47	to	to	ADP
bptjm-71	19	48	neuronal	neuronal	ADJ
bptjm-71	19	49	injury	injury	NOUN
bptjm-71	19	50	and	and	CCONJ
bptjm-71	19	51	demyelination	demyelination	NOUN
bptjm-71	19	52	.	.	PUNCT
bptjm-71	20	1	in	in	ADP
bptjm-71	20	2	areas	area	NOUN
bptjm-71	20	3	of	of	ADP
bptjm-71	20	4	the	the	DET
bptjm-71	20	5	brain	brain	NOUN
bptjm-71	20	6	of	of	ADP
bptjm-71	20	7	ad	ad	NOUN
bptjm-71	20	8	patients	patient	NOUN
bptjm-71	20	9	,	,	PUNCT
bptjm-71	20	10	where	where	SCONJ
bptjm-71	20	11	there	there	PRON
bptjm-71	20	12	is	be	VERB
bptjm-71	20	13	elevated	elevate	VERB
bptjm-71	20	14	aβ	aβ	PRON
bptjm-71	20	15	plaque	plaque	NOUN
bptjm-71	20	16	and	and	CCONJ
bptjm-71	20	17	neural	neural	ADJ
bptjm-71	20	18	degeneration	degeneration	NOUN
bptjm-71	20	19	and	and	CCONJ
bptjm-71	20	20	berkeley	berkeley	PROPN
bptjm-71	20	21	pharma	pharma	PROPN
bptjm-71	20	22	tech	tech	NOUN
bptjm-71	20	23	journal	journal	NOUN
bptjm-71	20	24	of	of	ADP
bptjm-71	20	25	medicine	medicine	NOUN
bptjm-71	20	26	|	|	ADV
bptjm-71	20	27	44	44	NUM
bptjm-71	20	28	inflammation	inflammation	NOUN
bptjm-71	20	29	,	,	PUNCT
bptjm-71	20	30	there	there	PRON
bptjm-71	20	31	is	be	VERB
bptjm-71	20	32	a	a	DET
bptjm-71	20	33	notable	notable	ADJ
bptjm-71	20	34	correlation	correlation	NOUN
bptjm-71	20	35	with	with	ADP
bptjm-71	20	36	the	the	DET
bptjm-71	20	37	presence	presence	NOUN
bptjm-71	20	38	of	of	ADP
bptjm-71	20	39	senescent	senescent	ADJ
bptjm-71	20	40	opc	opc	PROPN
bptjm-71	20	41	populations.5	populations.5	PROPN
bptjm-71	20	42	considering	consider	VERB
bptjm-71	20	43	the	the	DET
bptjm-71	20	44	role	role	NOUN
bptjm-71	20	45	of	of	ADP
bptjm-71	20	46	senescent	senescent	ADJ
bptjm-71	20	47	glial	glial	ADJ
bptjm-71	20	48	cells	cell	NOUN
bptjm-71	20	49	in	in	ADP
bptjm-71	20	50	aging	age	VERB
bptjm-71	20	51	-	-	PUNCT
bptjm-71	20	52	related	relate	VERB
bptjm-71	20	53	neurodegenerative	neurodegenerative	ADJ
bptjm-71	20	54	diseases	disease	NOUN
bptjm-71	20	55	,	,	PUNCT
bptjm-71	20	56	targeting	target	VERB
bptjm-71	20	57	these	these	DET
bptjm-71	20	58	cells	cell	NOUN
bptjm-71	20	59	has	have	AUX
bptjm-71	20	60	emerged	emerge	VERB
bptjm-71	20	61	as	as	ADP
bptjm-71	20	62	a	a	DET
bptjm-71	20	63	potential	potential	ADJ
bptjm-71	20	64	therapeutic	therapeutic	ADJ
bptjm-71	20	65	approach	approach	NOUN
bptjm-71	20	66	to	to	PART
bptjm-71	20	67	tackle	tackle	VERB
bptjm-71	20	68	such	such	ADJ
bptjm-71	20	69	conditions	condition	NOUN
bptjm-71	20	70	effectively	effectively	ADV
bptjm-71	20	71	.	.	PUNCT
bptjm-71	21	1	we	we	PRON
bptjm-71	21	2	may	may	AUX
bptjm-71	21	3	develop	develop	VERB
bptjm-71	21	4	strategies	strategy	NOUN
bptjm-71	21	5	to	to	PART
bptjm-71	21	6	promote	promote	VERB
bptjm-71	21	7	healthier	healthy	ADJ
bptjm-71	21	8	aging	aging	NOUN
bptjm-71	21	9	and	and	CCONJ
bptjm-71	21	10	reduce	reduce	VERB
bptjm-71	21	11	the	the	DET
bptjm-71	21	12	burden	burden	NOUN
bptjm-71	21	13	of	of	ADP
bptjm-71	21	14	neurodegenerative	neurodegenerative	ADJ
bptjm-71	21	15	diseases	disease	NOUN
bptjm-71	21	16	.	.	PUNCT
bptjm-71	22	1	2	2	X
bptjm-71	22	2	.	.	NUM
bptjm-71	22	3	mechanisms	mechanism	NOUN
bptjm-71	22	4	of	of	ADP
bptjm-71	22	5	senescence	senescence	NOUN
bptjm-71	22	6	-	-	PUNCT
bptjm-71	22	7	associated	associate	VERB
bptjm-71	22	8	neurodegeneration	neurodegeneration	NOUN
bptjm-71	22	9	in	in	ADP
bptjm-71	22	10	the	the	DET
bptjm-71	22	11	realm	realm	NOUN
bptjm-71	22	12	of	of	ADP
bptjm-71	22	13	neurodegeneration	neurodegeneration	NOUN
bptjm-71	22	14	,	,	PUNCT
bptjm-71	22	15	the	the	DET
bptjm-71	22	16	intricate	intricate	ADJ
bptjm-71	22	17	interplay	interplay	NOUN
bptjm-71	22	18	between	between	ADP
bptjm-71	22	19	cellular	cellular	ADJ
bptjm-71	22	20	senescence	senescence	NOUN
bptjm-71	22	21	and	and	CCONJ
bptjm-71	22	22	the	the	DET
bptjm-71	22	23	emergence	emergence	NOUN
bptjm-71	22	24	of	of	ADP
bptjm-71	22	25	pathological	pathological	ADJ
bptjm-71	22	26	hallmarks	hallmark	NOUN
bptjm-71	22	27	such	such	ADJ
bptjm-71	22	28	as	as	ADP
bptjm-71	22	29	sasps	sasps	NOUN
bptjm-71	22	30	and	and	CCONJ
bptjm-71	22	31	tau	tau	PROPN
bptjm-71	22	32	pathology	pathology	NOUN
bptjm-71	22	33	has	have	AUX
bptjm-71	22	34	garnered	garner	VERB
bptjm-71	22	35	significant	significant	ADJ
bptjm-71	22	36	attention	attention	NOUN
bptjm-71	22	37	.	.	PUNCT
bptjm-71	23	1	these	these	DET
bptjm-71	23	2	mechanisms	mechanism	NOUN
bptjm-71	23	3	not	not	PART
bptjm-71	23	4	only	only	ADV
bptjm-71	23	5	shed	shed	VERB
bptjm-71	23	6	light	light	NOUN
bptjm-71	23	7	on	on	ADP
bptjm-71	23	8	the	the	DET
bptjm-71	23	9	complex	complex	ADJ
bptjm-71	23	10	processes	process	NOUN
bptjm-71	23	11	underlying	underlie	VERB
bptjm-71	23	12	aging	age	VERB
bptjm-71	23	13	-	-	PUNCT
bptjm-71	23	14	related	relate	VERB
bptjm-71	23	15	neurological	neurological	ADJ
bptjm-71	23	16	disorders	disorder	NOUN
bptjm-71	23	17	but	but	CCONJ
bptjm-71	23	18	also	also	ADV
bptjm-71	23	19	offer	offer	VERB
bptjm-71	23	20	insights	insight	NOUN
bptjm-71	23	21	into	into	ADP
bptjm-71	23	22	potential	potential	ADJ
bptjm-71	23	23	avenues	avenue	NOUN
bptjm-71	23	24	for	for	ADP
bptjm-71	23	25	therapeutic	therapeutic	ADJ
bptjm-71	23	26	interventions	intervention	NOUN
bptjm-71	23	27	.	.	PUNCT
bptjm-71	24	1	2.1	2.1	NUM
bptjm-71	24	2	sasp	sasp	NOUN
bptjm-71	24	3	it	it	PRON
bptjm-71	24	4	was	be	AUX
bptjm-71	24	5	previously	previously	ADV
bptjm-71	24	6	believed	believe	VERB
bptjm-71	24	7	that	that	SCONJ
bptjm-71	24	8	senescent	senescent	ADJ
bptjm-71	24	9	cells	cell	NOUN
bptjm-71	24	10	lack	lack	VERB
bptjm-71	24	11	function	function	NOUN
bptjm-71	24	12	;	;	PUNCT
bptjm-71	24	13	however	however	ADV
bptjm-71	24	14	,	,	PUNCT
bptjm-71	24	15	in	in	ADP
bptjm-71	24	16	reality	reality	NOUN
bptjm-71	24	17	they	they	PRON
bptjm-71	24	18	simply	simply	ADV
bptjm-71	24	19	have	have	AUX
bptjm-71	24	20	altered	alter	VERB
bptjm-71	24	21	important	important	ADJ
bptjm-71	24	22	morphological	morphological	ADJ
bptjm-71	24	23	functions.6	functions.6	PROPN
bptjm-71	24	24	many	many	ADJ
bptjm-71	24	25	altered	alter	VERB
bptjm-71	24	26	functions	function	NOUN
bptjm-71	24	27	fall	fall	VERB
bptjm-71	24	28	under	under	ADP
bptjm-71	24	29	sasp	sasp	NOUN
bptjm-71	24	30	,	,	PUNCT
bptjm-71	24	31	which	which	PRON
bptjm-71	24	32	is	be	AUX
bptjm-71	24	33	a	a	DET
bptjm-71	24	34	core	core	ADJ
bptjm-71	24	35	feature	feature	NOUN
bptjm-71	24	36	of	of	ADP
bptjm-71	24	37	most	most	ADJ
bptjm-71	24	38	senescent	senescent	ADJ
bptjm-71	24	39	cells.7	cells.7	NOUN
bptjm-71	24	40	sasp	sasp	NOUN
bptjm-71	24	41	is	be	AUX
bptjm-71	24	42	mainly	mainly	ADV
bptjm-71	24	43	characterized	characterize	VERB
bptjm-71	24	44	by	by	ADP
bptjm-71	24	45	the	the	DET
bptjm-71	24	46	production	production	NOUN
bptjm-71	24	47	and	and	CCONJ
bptjm-71	24	48	secretion	secretion	NOUN
bptjm-71	24	49	of	of	ADP
bptjm-71	24	50	factors	factor	NOUN
bptjm-71	24	51	like	like	ADP
bptjm-71	24	52	cytokines	cytokine	NOUN
bptjm-71	24	53	,	,	PUNCT
bptjm-71	24	54	chemokines	chemokine	NOUN
bptjm-71	24	55	,	,	PUNCT
bptjm-71	24	56	and	and	CCONJ
bptjm-71	24	57	other	other	ADJ
bptjm-71	24	58	molecules	molecule	NOUN
bptjm-71	24	59	that	that	PRON
bptjm-71	24	60	create	create	VERB
bptjm-71	24	61	an	an	DET
bptjm-71	24	62	inflammatory	inflammatory	ADJ
bptjm-71	24	63	microenvironment.6	microenvironment.6	NOUN
bptjm-71	24	64	the	the	DET
bptjm-71	24	65	main	main	ADJ
bptjm-71	24	66	function	function	NOUN
bptjm-71	24	67	of	of	ADP
bptjm-71	24	68	sasp	sasp	NOUN
bptjm-71	24	69	is	be	AUX
bptjm-71	24	70	to	to	PART
bptjm-71	24	71	recruit	recruit	VERB
bptjm-71	24	72	immune	immune	ADJ
bptjm-71	24	73	cells	cell	NOUN
bptjm-71	24	74	for	for	ADP
bptjm-71	24	75	tissue	tissue	NOUN
bptjm-71	24	76	damage	damage	NOUN
bptjm-71	24	77	repair	repair	NOUN
bptjm-71	24	78	;	;	PUNCT
bptjm-71	24	79	however	however	ADV
bptjm-71	24	80	,	,	PUNCT
bptjm-71	24	81	an	an	DET
bptjm-71	24	82	abundance	abundance	NOUN
bptjm-71	24	83	of	of	ADP
bptjm-71	24	84	senescent	senescent	ADJ
bptjm-71	24	85	cells	cell	NOUN
bptjm-71	24	86	has	have	VERB
bptjm-71	24	87	a	a	DET
bptjm-71	24	88	negative	negative	ADJ
bptjm-71	24	89	effect	effect	NOUN
bptjm-71	24	90	on	on	ADP
bptjm-71	24	91	tissue	tissue	NOUN
bptjm-71	24	92	restoration	restoration	NOUN
bptjm-71	24	93	and	and	CCONJ
bptjm-71	24	94	leads	lead	VERB
bptjm-71	24	95	to	to	ADP
bptjm-71	24	96	a	a	DET
bptjm-71	24	97	chronic	chronic	ADJ
bptjm-71	24	98	,	,	PUNCT
bptjm-71	24	99	low	low	ADJ
bptjm-71	24	100	-	-	PUNCT
bptjm-71	24	101	grade	grade	NOUN
bptjm-71	24	102	inflammation	inflammation	NOUN
bptjm-71	24	103	called	call	VERB
bptjm-71	24	104	“	"	PUNCT
bptjm-71	24	105	inflammaging”.8	inflammaging”.8	NOUN
bptjm-71	24	106	activation	activation	NOUN
bptjm-71	24	107	of	of	ADP
bptjm-71	24	108	inflammaging	inflammage	VERB
bptjm-71	24	109	results	result	NOUN
bptjm-71	24	110	in	in	ADP
bptjm-71	24	111	decreased	decreased	ADJ
bptjm-71	24	112	clearance	clearance	NOUN
bptjm-71	24	113	of	of	ADP
bptjm-71	24	114	senescent	senescent	ADJ
bptjm-71	24	115	cells	cell	NOUN
bptjm-71	24	116	,	,	PUNCT
bptjm-71	24	117	establishing	establish	VERB
bptjm-71	24	118	a	a	DET
bptjm-71	24	119	positive	positive	ADJ
bptjm-71	24	120	feedback	feedback	NOUN
bptjm-71	24	121	mechanism	mechanism	NOUN
bptjm-71	24	122	that	that	PRON
bptjm-71	24	123	ultimately	ultimately	ADV
bptjm-71	24	124	further	further	ADJ
bptjm-71	24	125	fuels	fuel	NOUN
bptjm-71	24	126	inflammaging	inflammage	VERB
bptjm-71	24	127	.	.	PUNCT
bptjm-71	25	1	in	in	ADP
bptjm-71	25	2	an	an	DET
bptjm-71	25	3	autocrine	autocrine	NOUN
bptjm-71	25	4	or	or	CCONJ
bptjm-71	25	5	paracrine	paracrine	NOUN
bptjm-71	25	6	manner	manner	NOUN
bptjm-71	25	7	,	,	PUNCT
bptjm-71	25	8	senescent	senescent	ADJ
bptjm-71	25	9	cells	cell	NOUN
bptjm-71	25	10	can	can	AUX
bptjm-71	25	11	secrete	secrete	VERB
bptjm-71	25	12	sasp	sasp	NOUN
bptjm-71	25	13	factors	factor	NOUN
bptjm-71	25	14	that	that	PRON
bptjm-71	25	15	induce	induce	VERB
bptjm-71	25	16	neighboring	neighboring	NOUN
bptjm-71	25	17	cells	cell	NOUN
bptjm-71	25	18	to	to	ADP
bptjm-71	25	19	senescence	senescence	NOUN
bptjm-71	25	20	,	,	PUNCT
bptjm-71	25	21	furthering	further	VERB
bptjm-71	25	22	the	the	DET
bptjm-71	25	23	accumulation	accumulation	NOUN
bptjm-71	25	24	of	of	ADP
bptjm-71	25	25	senescent	senescent	ADJ
bptjm-71	25	26	cells	cell	NOUN
bptjm-71	25	27	(	(	PUNCT
bptjm-71	25	28	fig	fig	NOUN
bptjm-71	25	29	.	.	PUNCT
bptjm-71	25	30	1b	1b	NUM
bptjm-71	25	31	)	)	PUNCT
bptjm-71	25	32	.	.	PUNCT
bptjm-71	26	1	when	when	SCONJ
bptjm-71	26	2	this	this	DET
bptjm-71	26	3	process	process	NOUN
bptjm-71	26	4	occurs	occur	VERB
bptjm-71	26	5	in	in	ADP
bptjm-71	26	6	the	the	DET
bptjm-71	26	7	brain	brain	NOUN
bptjm-71	26	8	,	,	PUNCT
bptjm-71	26	9	it	it	PRON
bptjm-71	26	10	leads	lead	VERB
bptjm-71	26	11	to	to	ADP
bptjm-71	26	12	the	the	DET
bptjm-71	26	13	loss	loss	NOUN
bptjm-71	26	14	of	of	ADP
bptjm-71	26	15	neurons	neuron	NOUN
bptjm-71	26	16	,	,	PUNCT
bptjm-71	26	17	resulting	result	VERB
bptjm-71	26	18	in	in	ADP
bptjm-71	26	19	the	the	DET
bptjm-71	26	20	initiation	initiation	NOUN
bptjm-71	26	21	,	,	PUNCT
bptjm-71	26	22	severity	severity	NOUN
bptjm-71	26	23	,	,	PUNCT
bptjm-71	26	24	and	and	CCONJ
bptjm-71	26	25	progression	progression	NOUN
bptjm-71	26	26	of	of	ADP
bptjm-71	26	27	neurodegeneration.9	neurodegeneration.9	PROPN
bptjm-71	26	28	berkeley	berkeley	PROPN
bptjm-71	26	29	pharma	pharma	PROPN
bptjm-71	26	30	tech	tech	NOUN
bptjm-71	26	31	journal	journal	NOUN
bptjm-71	26	32	of	of	ADP
bptjm-71	26	33	medicine	medicine	NOUN
bptjm-71	26	34	|	|	ADV
bptjm-71	26	35	45	45	NUM
bptjm-71	26	36	figure	figure	NOUN
bptjm-71	26	37	1	1	NUM
bptjm-71	26	38	:	:	PUNCT
bptjm-71	26	39	mechanisms	mechanism	NOUN
bptjm-71	26	40	triggering	trigger	VERB
bptjm-71	26	41	cellular	cellular	ADJ
bptjm-71	26	42	senescence	senescence	NOUN
bptjm-71	26	43	.	.	PUNCT
bptjm-71	27	1	(	(	PUNCT
bptjm-71	27	2	a	a	X
bptjm-71	27	3	)	)	PUNCT
bptjm-71	27	4	cellular	cellular	ADJ
bptjm-71	27	5	senescence	senescence	NOUN
bptjm-71	27	6	is	be	AUX
bptjm-71	27	7	triggered	trigger	VERB
bptjm-71	27	8	by	by	ADP
bptjm-71	27	9	stressors	stressor	NOUN
bptjm-71	27	10	such	such	ADJ
bptjm-71	27	11	as	as	ADP
bptjm-71	27	12	dna	dna	PROPN
bptjm-71	27	13	damage	damage	NOUN
bptjm-71	27	14	,	,	PUNCT
bptjm-71	27	15	telomere	telomere	NOUN
bptjm-71	27	16	shortening	shortening	NOUN
bptjm-71	27	17	,	,	PUNCT
bptjm-71	27	18	mitochondrial	mitochondrial	ADJ
bptjm-71	27	19	dysfunction	dysfunction	NOUN
bptjm-71	27	20	,	,	PUNCT
bptjm-71	27	21	tumor	tumor	NOUN
bptjm-71	27	22	suppression	suppression	NOUN
bptjm-71	27	23	,	,	PUNCT
bptjm-71	27	24	oxidative	oxidative	ADJ
bptjm-71	27	25	stress	stress	NOUN
bptjm-71	27	26	,	,	PUNCT
bptjm-71	27	27	ionizing	ionize	VERB
bptjm-71	27	28	radiation	radiation	NOUN
bptjm-71	27	29	,	,	PUNCT
bptjm-71	27	30	and	and	CCONJ
bptjm-71	27	31	many	many	ADJ
bptjm-71	27	32	other	other	ADJ
bptjm-71	27	33	abnormal	abnormal	ADJ
bptjm-71	27	34	factors	factor	NOUN
bptjm-71	27	35	.	.	PUNCT
bptjm-71	28	1	(	(	PUNCT
bptjm-71	28	2	b	b	X
bptjm-71	28	3	)	)	PUNCT
bptjm-71	28	4	through	through	ADP
bptjm-71	28	5	the	the	DET
bptjm-71	28	6	release	release	NOUN
bptjm-71	28	7	of	of	ADP
bptjm-71	28	8	sasp	sasp	NOUN
bptjm-71	28	9	factors	factor	NOUN
bptjm-71	28	10	,	,	PUNCT
bptjm-71	28	11	senescent	senescent	ADJ
bptjm-71	28	12	cells	cell	NOUN
bptjm-71	28	13	can	can	AUX
bptjm-71	28	14	use	use	VERB
bptjm-71	28	15	autocrine	autocrine	NOUN
bptjm-71	28	16	or	or	CCONJ
bptjm-71	28	17	paracrine	paracrine	NOUN
bptjm-71	28	18	signaling	signal	VERB
bptjm-71	28	19	to	to	PART
bptjm-71	28	20	induce	induce	VERB
bptjm-71	28	21	senescence	senescence	NOUN
bptjm-71	28	22	in	in	ADP
bptjm-71	28	23	neighboring	neighboring	NOUN
bptjm-71	28	24	cells	cell	NOUN
bptjm-71	28	25	.	.	PUNCT
bptjm-71	29	1	early	early	ADJ
bptjm-71	29	2	sasp	sasp	NOUN
bptjm-71	29	3	is	be	AUX
bptjm-71	29	4	often	often	ADV
bptjm-71	29	5	induced	induce	VERB
bptjm-71	29	6	by	by	ADP
bptjm-71	29	7	transforming	transform	VERB
bptjm-71	29	8	growth	growth	NOUN
bptjm-71	29	9	factor	factor	NOUN
bptjm-71	29	10	-	-	PUNCT
bptjm-71	29	11	β	β	X
bptjm-71	29	12	(	(	PUNCT
bptjm-71	29	13	tgf	tgf	PROPN
bptjm-71	29	14	-	-	PUNCT
bptjm-71	29	15	β	β	NOUN
bptjm-71	29	16	)	)	PUNCT
bptjm-71	29	17	,	,	PUNCT
bptjm-71	29	18	secreted	secrete	VERB
bptjm-71	29	19	by	by	ADP
bptjm-71	29	20	senescent	senescent	ADJ
bptjm-71	29	21	cells	cell	NOUN
bptjm-71	29	22	.	.	PUNCT
bptjm-71	30	1	tgf	tgf	PROPN
bptjm-71	30	2	-	-	PUNCT
bptjm-71	30	3	β	β	PROPN
bptjm-71	30	4	can	can	AUX
bptjm-71	30	5	also	also	ADV
bptjm-71	30	6	help	help	VERB
bptjm-71	30	7	maintain	maintain	VERB
bptjm-71	30	8	the	the	DET
bptjm-71	30	9	secretory	secretory	ADJ
bptjm-71	30	10	phenotype	phenotype	NOUN
bptjm-71	30	11	if	if	SCONJ
bptjm-71	30	12	its	its	PRON
bptjm-71	30	13	target	target	NOUN
bptjm-71	30	14	cell	cell	NOUN
bptjm-71	30	15	is	be	AUX
bptjm-71	30	16	already	already	ADV
bptjm-71	30	17	senescent	senescent	ADJ
bptjm-71	30	18	.	.	PUNCT
bptjm-71	31	1	if	if	SCONJ
bptjm-71	31	2	early	early	ADJ
bptjm-71	31	3	sasp	sasp	NOUN
bptjm-71	31	4	is	be	AUX
bptjm-71	31	5	upregulated	upregulate	VERB
bptjm-71	31	6	for	for	ADP
bptjm-71	31	7	an	an	DET
bptjm-71	31	8	extended	extended	ADJ
bptjm-71	31	9	period	period	NOUN
bptjm-71	31	10	of	of	ADP
bptjm-71	31	11	time	time	NOUN
bptjm-71	31	12	,	,	PUNCT
bptjm-71	31	13	it	it	PRON
bptjm-71	31	14	transforms	transform	VERB
bptjm-71	31	15	into	into	ADP
bptjm-71	31	16	late	late	ADJ
bptjm-71	31	17	sasp	sasp	NOUN
bptjm-71	31	18	,	,	PUNCT
bptjm-71	31	19	which	which	PRON
bptjm-71	31	20	is	be	AUX
bptjm-71	31	21	regulated	regulate	VERB
bptjm-71	31	22	mainly	mainly	ADV
bptjm-71	31	23	through	through	ADP
bptjm-71	31	24	transcription	transcription	NOUN
bptjm-71	31	25	factors	factor	NOUN
bptjm-71	31	26	ccaat	ccaat	NOUN
bptjm-71	31	27	/	/	SYM
bptjm-71	31	28	enhancer	enhancer	NOUN
bptjm-71	31	29	-	-	PUNCT
bptjm-71	31	30	binding	bind	VERB
bptjm-71	31	31	protein	protein	NOUN
bptjm-71	31	32	β	β	X
bptjm-71	31	33	(	(	PUNCT
bptjm-71	31	34	c	c	X
bptjm-71	31	35	/	/	SYM
bptjm-71	31	36	ebp	ebp	PROPN
bptjm-71	31	37	β	β	X
bptjm-71	31	38	)	)	PUNCT
bptjm-71	31	39	and	and	CCONJ
bptjm-71	31	40	nuclear	nuclear	ADJ
bptjm-71	31	41	factor	factor	NOUN
bptjm-71	31	42	(	(	PUNCT
bptjm-71	31	43	nf)-κb	nf)-κb	NOUN
bptjm-71	31	44	.	.	PUNCT
bptjm-71	32	1	c	c	X
bptjm-71	32	2	/	/	SYM
bptjm-71	32	3	ebp	ebp	PROPN
bptjm-71	32	4	β	β	PROPN
bptjm-71	32	5	regulates	regulate	VERB
bptjm-71	32	6	the	the	DET
bptjm-71	32	7	expression	expression	NOUN
bptjm-71	32	8	of	of	ADP
bptjm-71	32	9	various	various	ADJ
bptjm-71	32	10	sasp	sasp	NOUN
bptjm-71	32	11	factors	factor	NOUN
bptjm-71	32	12	,	,	PUNCT
bptjm-71	32	13	such	such	ADJ
bptjm-71	32	14	as	as	ADP
bptjm-71	32	15	interleukin	interleukin	NOUN
bptjm-71	32	16	(	(	PUNCT
bptjm-71	32	17	il)-1β	il)-1β	PROPN
bptjm-71	32	18	,	,	PUNCT
bptjm-71	32	19	il-6	il-6	NOUN
bptjm-71	32	20	,	,	PUNCT
bptjm-71	32	21	and	and	CCONJ
bptjm-71	32	22	il-8	il-8	NOUN
bptjm-71	32	23	.	.	PUNCT
bptjm-71	33	1	late	late	ADJ
bptjm-71	33	2	sasp	sasp	NOUN
bptjm-71	33	3	expression	expression	NOUN
bptjm-71	33	4	is	be	AUX
bptjm-71	33	5	induced	induce	VERB
bptjm-71	33	6	when	when	SCONJ
bptjm-71	33	7	c	c	PROPN
bptjm-71	33	8	/	/	SYM
bptjm-71	33	9	ebp	ebp	PROPN
bptjm-71	33	10	β	β	PROPN
bptjm-71	33	11	levels	level	NOUN
bptjm-71	33	12	increase	increase	VERB
bptjm-71	33	13	,	,	PUNCT
bptjm-71	33	14	suggesting	suggest	VERB
bptjm-71	33	15	c	c	PROPN
bptjm-71	33	16	/	/	SYM
bptjm-71	33	17	ebp	ebp	PROPN
bptjm-71	33	18	β	β	X
bptjm-71	33	19	is	be	AUX
bptjm-71	33	20	a	a	DET
bptjm-71	33	21	key	key	ADJ
bptjm-71	33	22	regulator	regulator	NOUN
bptjm-71	33	23	of	of	ADP
bptjm-71	33	24	the	the	DET
bptjm-71	33	25	early	early	ADJ
bptjm-71	33	26	to	to	PART
bptjm-71	33	27	late	late	ADJ
bptjm-71	33	28	sasp	sasp	NOUN
bptjm-71	33	29	transition.7	transition.7	PROPN
bptjm-71	33	30	however	however	ADV
bptjm-71	33	31	,	,	PUNCT
bptjm-71	33	32	nf	nf	ADJ
bptjm-71	33	33	-	-	PUNCT
bptjm-71	33	34	κb	κb	ADJ
bptjm-71	33	35	signaling	signal	VERB
bptjm-71	33	36	is	be	AUX
bptjm-71	33	37	the	the	DET
bptjm-71	33	38	main	main	ADJ
bptjm-71	33	39	signaling	signal	VERB
bptjm-71	33	40	pathway	pathway	NOUN
bptjm-71	33	41	in	in	ADP
bptjm-71	33	42	late	late	ADJ
bptjm-71	33	43	sasp	sasp	NOUN
bptjm-71	33	44	induction	induction	NOUN
bptjm-71	33	45	.	.	PUNCT
bptjm-71	34	1	nf	nf	X
bptjm-71	34	2	-	-	PUNCT
bptjm-71	34	3	κb	κb	NOUN
bptjm-71	34	4	activation	activation	NOUN
bptjm-71	34	5	induces	induce	VERB
bptjm-71	34	6	expression	expression	NOUN
bptjm-71	34	7	of	of	ADP
bptjm-71	34	8	inflammatory	inflammatory	ADJ
bptjm-71	34	9	mediators	mediator	NOUN
bptjm-71	34	10	il-6	il-6	NOUN
bptjm-71	34	11	,	,	PUNCT
bptjm-71	34	12	il-8	il-8	NOUN
bptjm-71	34	13	,	,	PUNCT
bptjm-71	34	14	and	and	CCONJ
bptjm-71	34	15	il-1α	il-1α	PROPN
bptjm-71	34	16	.	.	PUNCT
bptjm-71	35	1	in	in	ADP
bptjm-71	35	2	a	a	DET
bptjm-71	35	3	positive	positive	ADJ
bptjm-71	35	4	feedback	feedback	NOUN
bptjm-71	35	5	loop	loop	NOUN
bptjm-71	35	6	,	,	PUNCT
bptjm-71	35	7	il-1α	il-1α	NOUN
bptjm-71	35	8	contributes	contribute	VERB
bptjm-71	35	9	to	to	AUX
bptjm-71	35	10	sasp	sasp	NOUN
bptjm-71	35	11	maintenance	maintenance	NOUN
bptjm-71	35	12	by	by	ADP
bptjm-71	35	13	regulating	regulate	VERB
bptjm-71	35	14	nf	nf	NOUN
bptjm-71	35	15	-	-	PUNCT
bptjm-71	35	16	κb	κb	NOUN
bptjm-71	35	17	and	and	CCONJ
bptjm-71	35	18	c	c	X
bptjm-71	35	19	/	/	SYM
bptjm-71	35	20	ebp	ebp	PROPN
bptjm-71	35	21	β	β	X
bptjm-71	35	22	dna	dna	NOUN
bptjm-71	35	23	binding	bind	VERB
bptjm-71	35	24	activities	activity	NOUN
bptjm-71	35	25	to	to	PART
bptjm-71	35	26	induce	induce	VERB
bptjm-71	35	27	further	further	ADJ
bptjm-71	35	28	il-6	il-6	NOUN
bptjm-71	35	29	and	and	CCONJ
bptjm-71	35	30	il-8	il-8	VERB
bptjm-71	35	31	transcription	transcription	NOUN
bptjm-71	35	32	.	.	PUNCT
bptjm-71	36	1	this	this	DET
bptjm-71	36	2	feedback	feedback	NOUN
bptjm-71	36	3	loop	loop	NOUN
bptjm-71	36	4	is	be	AUX
bptjm-71	36	5	regulated	regulate	VERB
bptjm-71	36	6	by	by	ADP
bptjm-71	36	7	rapamycin	rapamycin	PROPN
bptjm-71	36	8	-	-	PUNCT
bptjm-71	36	9	mtor	mtor	NOUN
bptjm-71	36	10	signaling.8	signaling.8	PROPN
bptjm-71	36	11	nf	nf	PROPN
bptjm-71	36	12	-	-	PUNCT
bptjm-71	36	13	κb	κb	NOUN
bptjm-71	36	14	signaling	signaling	NOUN
bptjm-71	36	15	is	be	AUX
bptjm-71	36	16	also	also	ADV
bptjm-71	36	17	provoked	provoke	VERB
bptjm-71	36	18	by	by	ADP
bptjm-71	36	19	dna	dna	PROPN
bptjm-71	36	20	damage	damage	NOUN
bptjm-71	36	21	through	through	ADP
bptjm-71	36	22	signaling	signal	VERB
bptjm-71	36	23	pathways	pathway	NOUN
bptjm-71	36	24	that	that	PRON
bptjm-71	36	25	include	include	VERB
bptjm-71	36	26	p38	p38	NOUN
bptjm-71	36	27	mitogen	mitogen	NOUN
bptjm-71	36	28	-	-	PUNCT
bptjm-71	36	29	activated	activate	VERB
bptjm-71	36	30	protein	protein	NOUN
bptjm-71	36	31	kinase	kinase	NOUN
bptjm-71	36	32	(	(	PUNCT
bptjm-71	36	33	p38	p38	NOUN
bptjm-71	36	34	mapk	mapk	NOUN
bptjm-71	36	35	)	)	PUNCT
bptjm-71	36	36	and	and	CCONJ
bptjm-71	36	37	retinoic	retinoic	PROPN
bptjm-71	36	38	acid	acid	PROPN
bptjm-71	36	39	inducible	inducible	ADJ
bptjm-71	36	40	gene-1	gene-1	PROPN
bptjm-71	36	41	(	(	PUNCT
bptjm-71	36	42	rig-1).10	rig-1).10	PROPN
bptjm-71	36	43	p38	p38	NOUN
bptjm-71	36	44	mapk	mapk	NOUN
bptjm-71	36	45	acts	act	VERB
bptjm-71	36	46	to	to	PART
bptjm-71	36	47	stimulate	stimulate	VERB
bptjm-71	36	48	nf	nf	NOUN
bptjm-71	36	49	-	-	PUNCT
bptjm-71	36	50	κb	κb	NOUN
bptjm-71	36	51	through	through	ADP
bptjm-71	36	52	the	the	DET
bptjm-71	36	53	activation	activation	NOUN
bptjm-71	36	54	of	of	ADP
bptjm-71	36	55	mapk	mapk	NOUN
bptjm-71	36	56	-	-	PUNCT
bptjm-71	36	57	activated	activate	VERB
bptjm-71	36	58	protein	protein	NOUN
bptjm-71	36	59	kinase	kinase	NOUN
bptjm-71	36	60	2	2	NUM
bptjm-71	36	61	(	(	PUNCT
bptjm-71	36	62	mk2),8	mk2),8	PROPN
bptjm-71	36	63	and	and	CCONJ
bptjm-71	36	64	p38	p38	NOUN
bptjm-71	36	65	mapk	mapk	PROPN
bptjm-71	36	66	berkeley	berkeley	PROPN
bptjm-71	36	67	pharma	pharma	PROPN
bptjm-71	36	68	tech	tech	NOUN
bptjm-71	36	69	journal	journal	NOUN
bptjm-71	36	70	of	of	ADP
bptjm-71	36	71	medicine	medicine	NOUN
bptjm-71	37	1	|	|	ADV
bptjm-71	37	2	46	46	NUM
bptjm-71	37	3	signaling	signal	VERB
bptjm-71	37	4	itself	itself	PRON
bptjm-71	37	5	can	can	AUX
bptjm-71	37	6	be	be	AUX
bptjm-71	37	7	induced	induce	VERB
bptjm-71	37	8	by	by	ADP
bptjm-71	37	9	environmental	environmental	ADJ
bptjm-71	37	10	stress	stress	NOUN
bptjm-71	37	11	or	or	CCONJ
bptjm-71	37	12	chronic	chronic	ADJ
bptjm-71	37	13	inflammation	inflammation	NOUN
bptjm-71	37	14	,	,	PUNCT
bptjm-71	37	15	such	such	ADJ
bptjm-71	37	16	as	as	ADP
bptjm-71	37	17	inflammaging	inflammage	VERB
bptjm-71	37	18	(	(	PUNCT
bptjm-71	37	19	fig	fig	NOUN
bptjm-71	37	20	.	.	PUNCT
bptjm-71	38	1	2).10	2).10	NUM
bptjm-71	38	2	persistent	persistent	ADJ
bptjm-71	38	3	nf	nf	ADJ
bptjm-71	38	4	-	-	PUNCT
bptjm-71	38	5	κb	κb	NOUN
bptjm-71	38	6	activation	activation	NOUN
bptjm-71	38	7	is	be	AUX
bptjm-71	38	8	partially	partially	ADV
bptjm-71	38	9	maintained	maintain	VERB
bptjm-71	38	10	by	by	ADP
bptjm-71	38	11	tumor	tumor	NOUN
bptjm-71	38	12	necrosis	necrosis	NOUN
bptjm-71	38	13	factor	factor	NOUN
bptjm-71	38	14	(	(	PUNCT
bptjm-71	38	15	tnf)-α	tnf)-α	PROPN
bptjm-71	38	16	.	.	PUNCT
bptjm-71	39	1	upon	upon	SCONJ
bptjm-71	39	2	tnf	tnf	PROPN
bptjm-71	39	3	-	-	PUNCT
bptjm-71	39	4	α	α	NOUN
bptjm-71	39	5	activation	activation	NOUN
bptjm-71	39	6	,	,	PUNCT
bptjm-71	39	7	ak	ak	PROPN
bptjm-71	39	8	kinase	kinase	PROPN
bptjm-71	39	9	is	be	AUX
bptjm-71	39	10	phosphorylated	phosphorylate	VERB
bptjm-71	39	11	,	,	PUNCT
bptjm-71	39	12	which	which	PRON
bptjm-71	39	13	subsequently	subsequently	ADV
bptjm-71	39	14	phosphorylates	phosphorylate	VERB
bptjm-71	39	15	signal	signal	NOUN
bptjm-71	39	16	transducers	transducer	NOUN
bptjm-71	39	17	and	and	CCONJ
bptjm-71	39	18	activators	activator	NOUN
bptjm-71	39	19	of	of	ADP
bptjm-71	39	20	transcription	transcription	NOUN
bptjm-71	39	21	3	3	NUM
bptjm-71	39	22	(	(	PUNCT
bptjm-71	39	23	stat3	stat3	NOUN
bptjm-71	39	24	)	)	PUNCT
bptjm-71	39	25	.	.	PUNCT
bptjm-71	40	1	these	these	DET
bptjm-71	40	2	phosphorylated	phosphorylate	VERB
bptjm-71	40	3	stat3	stat3	NOUN
bptjm-71	40	4	molecules	molecule	NOUN
bptjm-71	40	5	then	then	ADV
bptjm-71	40	6	migrate	migrate	VERB
bptjm-71	40	7	to	to	ADP
bptjm-71	40	8	the	the	DET
bptjm-71	40	9	nucleus	nucleus	NOUN
bptjm-71	40	10	,	,	PUNCT
bptjm-71	40	11	contributing	contribute	VERB
bptjm-71	40	12	to	to	ADP
bptjm-71	40	13	prolonged	prolonged	ADJ
bptjm-71	40	14	activation	activation	NOUN
bptjm-71	40	15	of	of	ADP
bptjm-71	40	16	nf	nf	NOUN
bptjm-71	40	17	-	-	PUNCT
bptjm-71	40	18	κb	κb	NOUN
bptjm-71	40	19	and	and	CCONJ
bptjm-71	40	20	increased	increase	VERB
bptjm-71	40	21	expression	expression	NOUN
bptjm-71	40	22	of	of	ADP
bptjm-71	40	23	sasp	sasp	NOUN
bptjm-71	40	24	factors.8	factors.8	PROPN
bptjm-71	40	25	interestingly	interestingly	ADV
bptjm-71	40	26	,	,	PUNCT
bptjm-71	40	27	tnf	tnf	PROPN
bptjm-71	40	28	-	-	PUNCT
bptjm-71	40	29	α	α	PROPN
bptjm-71	40	30	itself	itself	PRON
bptjm-71	40	31	is	be	AUX
bptjm-71	40	32	a	a	DET
bptjm-71	40	33	common	common	ADJ
bptjm-71	40	34	cytokine	cytokine	NOUN
bptjm-71	40	35	secreted	secrete	VERB
bptjm-71	40	36	by	by	ADP
bptjm-71	40	37	sasp.4	sasp.4	PROPN
bptjm-71	40	38	thus	thus	ADV
bptjm-71	40	39	,	,	PUNCT
bptjm-71	40	40	its	its	PRON
bptjm-71	40	41	ability	ability	NOUN
bptjm-71	40	42	to	to	PART
bptjm-71	40	43	induce	induce	VERB
bptjm-71	40	44	sasp	sasp	NOUN
bptjm-71	40	45	through	through	ADP
bptjm-71	40	46	nf	nf	ADJ
bptjm-71	40	47	-	-	PUNCT
bptjm-71	40	48	κb	κb	NOUN
bptjm-71	40	49	activation	activation	NOUN
bptjm-71	40	50	presents	present	VERB
bptjm-71	40	51	another	another	DET
bptjm-71	40	52	positive	positive	ADJ
bptjm-71	40	53	feedback	feedback	NOUN
bptjm-71	40	54	loop	loop	NOUN
bptjm-71	40	55	that	that	PRON
bptjm-71	40	56	serves	serve	VERB
bptjm-71	40	57	to	to	PART
bptjm-71	40	58	maintain	maintain	VERB
bptjm-71	40	59	sasp	sasp	NOUN
bptjm-71	40	60	.	.	PUNCT
bptjm-71	41	1	persistent	persistent	ADJ
bptjm-71	41	2	sasp	sasp	NOUN
bptjm-71	41	3	expression	expression	NOUN
bptjm-71	41	4	through	through	ADP
bptjm-71	41	5	nf	nf	NOUN
bptjm-71	41	6	-	-	PUNCT
bptjm-71	41	7	κb	κb	NOUN
bptjm-71	41	8	,	,	PUNCT
bptjm-71	41	9	as	as	ADV
bptjm-71	41	10	well	well	ADV
bptjm-71	41	11	as	as	ADP
bptjm-71	41	12	other	other	ADJ
bptjm-71	41	13	contributing	contribute	VERB
bptjm-71	41	14	factors	factor	NOUN
bptjm-71	41	15	,	,	PUNCT
bptjm-71	41	16	induces	induce	VERB
bptjm-71	41	17	proinflammation	proinflammation	NOUN
bptjm-71	41	18	,	,	PUNCT
bptjm-71	41	19	which	which	PRON
bptjm-71	41	20	promotes	promote	VERB
bptjm-71	41	21	tissue	tissue	NOUN
bptjm-71	41	22	dysfunction	dysfunction	NOUN
bptjm-71	41	23	,	,	PUNCT
bptjm-71	41	24	cellular	cellular	ADJ
bptjm-71	41	25	aging	aging	NOUN
bptjm-71	41	26	,	,	PUNCT
bptjm-71	41	27	and	and	CCONJ
bptjm-71	41	28	other	other	ADJ
bptjm-71	41	29	aging	age	VERB
bptjm-71	41	30	-	-	PUNCT
bptjm-71	41	31	associated	associate	VERB
bptjm-71	41	32	issues	issue	NOUN
bptjm-71	41	33	(	(	PUNCT
bptjm-71	41	34	fig	fig	NOUN
bptjm-71	41	35	.	.	PUNCT
bptjm-71	42	1	2).8	2).8	NUM
bptjm-71	42	2	figure	figure	NOUN
bptjm-71	42	3	2	2	NUM
bptjm-71	42	4	:	:	PUNCT
bptjm-71	42	5	sasp	sasp	NOUN
bptjm-71	42	6	regulation	regulation	NOUN
bptjm-71	42	7	and	and	CCONJ
bptjm-71	42	8	neuroinflammation	neuroinflammation	NOUN
bptjm-71	42	9	pathways	pathway	NOUN
bptjm-71	42	10	.	.	PUNCT
bptjm-71	43	1	several	several	ADJ
bptjm-71	43	2	different	different	ADJ
bptjm-71	43	3	molecules	molecule	NOUN
bptjm-71	43	4	act	act	VERB
bptjm-71	43	5	through	through	ADP
bptjm-71	43	6	the	the	DET
bptjm-71	43	7	nf	nf	ADJ
bptjm-71	43	8	-	-	PUNCT
bptjm-71	43	9	κb	κb	NOUN
bptjm-71	43	10	pathway	pathway	NOUN
bptjm-71	43	11	to	to	PART
bptjm-71	43	12	activate	activate	VERB
bptjm-71	43	13	and	and	CCONJ
bptjm-71	43	14	regulate	regulate	VERB
bptjm-71	43	15	sasp	sasp	NOUN
bptjm-71	43	16	.	.	PUNCT
bptjm-71	44	1	upon	upon	SCONJ
bptjm-71	44	2	acquisition	acquisition	NOUN
bptjm-71	44	3	of	of	ADP
bptjm-71	44	4	sasp	sasp	NOUN
bptjm-71	44	5	,	,	PUNCT
bptjm-71	44	6	the	the	DET
bptjm-71	44	7	secreted	secreted	ADJ
bptjm-71	44	8	sasp	sasp	NOUN
bptjm-71	44	9	factors	factor	NOUN
bptjm-71	44	10	promote	promote	VERB
bptjm-71	44	11	autonomous	autonomous	ADJ
bptjm-71	44	12	neurotoxicity	neurotoxicity	NOUN
bptjm-71	44	13	and	and	CCONJ
bptjm-71	44	14	disrupt	disrupt	VERB
bptjm-71	44	15	normal	normal	ADJ
bptjm-71	44	16	function	function	NOUN
bptjm-71	44	17	in	in	ADP
bptjm-71	44	18	the	the	DET
bptjm-71	44	19	brain	brain	NOUN
bptjm-71	44	20	.	.	PUNCT
bptjm-71	45	1	in	in	ADP
bptjm-71	45	2	fact	fact	NOUN
bptjm-71	45	3	,	,	PUNCT
bptjm-71	45	4	it	it	PRON
bptjm-71	45	5	was	be	AUX
bptjm-71	45	6	found	find	VERB
bptjm-71	45	7	that	that	SCONJ
bptjm-71	45	8	treatment	treatment	NOUN
bptjm-71	45	9	of	of	ADP
bptjm-71	45	10	senescent	senescent	ADJ
bptjm-71	45	11	astrocytes	astrocyte	NOUN
bptjm-71	45	12	with	with	ADP
bptjm-71	45	13	an	an	DET
bptjm-71	45	14	antibody	antibody	NOUN
bptjm-71	45	15	that	that	PRON
bptjm-71	45	16	neutralizes	neutralize	VERB
bptjm-71	45	17	il-6	il-6	PRON
bptjm-71	45	18	,	,	PUNCT
bptjm-71	45	19	a	a	DET
bptjm-71	45	20	sasp	sasp	NOUN
bptjm-71	45	21	-	-	PUNCT
bptjm-71	45	22	associated	associate	VERB
bptjm-71	45	23	cytokine	cytokine	NOUN
bptjm-71	45	24	,	,	PUNCT
bptjm-71	45	25	alleviates	alleviate	VERB
bptjm-71	45	26	neuronal	neuronal	ADJ
bptjm-71	45	27	cell	cell	NOUN
bptjm-71	45	28	death.4	death.4	NOUN
bptjm-71	45	29	in	in	ADP
bptjm-71	45	30	vitro	vitro	X
bptjm-71	45	31	studies	study	NOUN
bptjm-71	45	32	showed	show	VERB
bptjm-71	45	33	that	that	SCONJ
bptjm-71	45	34	il-6	il-6	NOUN
bptjm-71	45	35	production	production	NOUN
bptjm-71	45	36	was	be	AUX
bptjm-71	45	37	found	find	VERB
bptjm-71	45	38	to	to	PART
bptjm-71	45	39	have	have	VERB
bptjm-71	45	40	the	the	DET
bptjm-71	45	41	most	most	ADV
bptjm-71	45	42	dramatic	dramatic	ADJ
bptjm-71	45	43	increase	increase	NOUN
bptjm-71	45	44	in	in	ADP
bptjm-71	45	45	senescent	senescent	ADJ
bptjm-71	45	46	astrocytes	astrocyte	NOUN
bptjm-71	45	47	,	,	PUNCT
bptjm-71	45	48	matching	match	VERB
bptjm-71	45	49	in	in	ADP
bptjm-71	45	50	vivo	vivo	ADJ
bptjm-71	45	51	findings	finding	NOUN
bptjm-71	45	52	of	of	ADP
bptjm-71	45	53	il-6	il-6	NUM
bptjm-71	45	54	berkeley	berkeley	PROPN
bptjm-71	45	55	pharma	pharma	PROPN
bptjm-71	45	56	tech	tech	NOUN
bptjm-71	45	57	journal	journal	NOUN
bptjm-71	45	58	of	of	ADP
bptjm-71	45	59	medicine	medicine	NOUN
bptjm-71	46	1	|	|	ADV
bptjm-71	46	2	47	47	NUM
bptjm-71	46	3	at	at	ADP
bptjm-71	46	4	elevated	elevated	ADJ
bptjm-71	46	5	levels	level	NOUN
bptjm-71	46	6	in	in	ADP
bptjm-71	46	7	the	the	DET
bptjm-71	46	8	cns	cns	NOUN
bptjm-71	46	9	in	in	ADP
bptjm-71	46	10	ad	ad	NOUN
bptjm-71	46	11	patients.6	patients.6	NOUN
bptjm-71	46	12	moreover	moreover	ADV
bptjm-71	46	13	,	,	PUNCT
bptjm-71	46	14	in	in	ADP
bptjm-71	46	15	a	a	DET
bptjm-71	46	16	study	study	NOUN
bptjm-71	46	17	with	with	ADP
bptjm-71	46	18	primary	primary	ADJ
bptjm-71	46	19	cortical	cortical	ADJ
bptjm-71	46	20	neurons	neuron	NOUN
bptjm-71	46	21	from	from	ADP
bptjm-71	46	22	senescence	senescence	NOUN
bptjm-71	46	23	accelerated	accelerate	VERB
bptjm-71	46	24	mouse	mouse	NOUN
bptjm-71	46	25	prone	prone	ADJ
bptjm-71	46	26	8	8	NUM
bptjm-71	46	27	(	(	PUNCT
bptjm-71	46	28	samp8	samp8	NOUN
bptjm-71	46	29	)	)	PUNCT
bptjm-71	46	30	mice	mouse	NOUN
bptjm-71	46	31	,	,	PUNCT
bptjm-71	46	32	sasp	sasp	NOUN
bptjm-71	46	33	factor	factor	NOUN
bptjm-71	46	34	plasminogen	plasminogen	NOUN
bptjm-71	46	35	activator	activator	NOUN
bptjm-71	46	36	inhibitor	inhibitor	NOUN
bptjm-71	46	37	1	1	NUM
bptjm-71	46	38	(	(	PUNCT
bptjm-71	46	39	pai-1	pai-1	X
bptjm-71	46	40	)	)	PUNCT
bptjm-71	46	41	was	be	AUX
bptjm-71	46	42	found	find	VERB
bptjm-71	46	43	to	to	PART
bptjm-71	46	44	promote	promote	VERB
bptjm-71	46	45	neuron	neuron	NOUN
bptjm-71	46	46	apoptosis	apoptosis	NOUN
bptjm-71	46	47	;	;	PUNCT
bptjm-71	46	48	however	however	ADV
bptjm-71	46	49	,	,	PUNCT
bptjm-71	46	50	the	the	DET
bptjm-71	46	51	exact	exact	ADJ
bptjm-71	46	52	mechanisms	mechanism	NOUN
bptjm-71	46	53	by	by	ADP
bptjm-71	46	54	which	which	PRON
bptjm-71	46	55	pai-1	pai-1	PRON
bptjm-71	46	56	carries	carry	VERB
bptjm-71	46	57	out	out	ADP
bptjm-71	46	58	this	this	DET
bptjm-71	46	59	activity	activity	NOUN
bptjm-71	46	60	is	be	AUX
bptjm-71	46	61	still	still	ADV
bptjm-71	46	62	unknown.11	unknown.11	ADJ
bptjm-71	46	63	several	several	ADJ
bptjm-71	46	64	sasp	sasp	NOUN
bptjm-71	46	65	factors	factor	NOUN
bptjm-71	46	66	have	have	AUX
bptjm-71	46	67	been	be	AUX
bptjm-71	46	68	linked	link	VERB
bptjm-71	46	69	to	to	ADP
bptjm-71	46	70	axonal	axonal	ADJ
bptjm-71	46	71	and	and	CCONJ
bptjm-71	46	72	myelin	myelin	NOUN
bptjm-71	46	73	injury	injury	NOUN
bptjm-71	46	74	.	.	PUNCT
bptjm-71	47	1	activation	activation	NOUN
bptjm-71	47	2	of	of	ADP
bptjm-71	47	3	sasp	sasp	NOUN
bptjm-71	47	4	in	in	ADP
bptjm-71	47	5	neurons	neuron	NOUN
bptjm-71	47	6	through	through	ADP
bptjm-71	47	7	the	the	DET
bptjm-71	47	8	lymphotoxin	lymphotoxin	PROPN
bptjm-71	47	9	-	-	PUNCT
bptjm-71	47	10	nf	nf	INTJ
bptjm-71	47	11	-	-	PUNCT
bptjm-71	47	12	κb	κb	NOUN
bptjm-71	47	13	pathway	pathway	NOUN
bptjm-71	47	14	was	be	AUX
bptjm-71	47	15	found	find	VERB
bptjm-71	47	16	to	to	PART
bptjm-71	47	17	trigger	trigger	VERB
bptjm-71	47	18	expression	expression	NOUN
bptjm-71	47	19	of	of	ADP
bptjm-71	47	20	chemokine	chemokine	ADJ
bptjm-71	47	21	cxcl13	cxcl13	NOUN
bptjm-71	47	22	,	,	PUNCT
bptjm-71	47	23	which	which	PRON
bptjm-71	47	24	recruited	recruit	VERB
bptjm-71	47	25	cd8	cd8	PROPN
bptjm-71	47	26	+	+	PROPN
bptjm-71	47	27	t	t	NOUN
bptjm-71	47	28	cells	cell	NOUN
bptjm-71	47	29	.	.	PUNCT
bptjm-71	48	1	cd8	cd8	PROPN
bptjm-71	48	2	+	+	PROPN
bptjm-71	48	3	t	t	PROPN
bptjm-71	48	4	cells	cell	NOUN
bptjm-71	48	5	then	then	ADV
bptjm-71	48	6	activated	activate	VERB
bptjm-71	48	7	caspase	caspase	NOUN
bptjm-71	48	8	3	3	NUM
bptjm-71	48	9	in	in	ADP
bptjm-71	48	10	injured	injure	VERB
bptjm-71	48	11	dorsal	dorsal	NOUN
bptjm-71	48	12	root	root	NOUN
bptjm-71	48	13	ganglia	ganglia	NOUN
bptjm-71	48	14	(	(	PUNCT
bptjm-71	48	15	drg	drg	NOUN
bptjm-71	48	16	)	)	PUNCT
bptjm-71	48	17	,	,	PUNCT
bptjm-71	48	18	which	which	PRON
bptjm-71	48	19	was	be	AUX
bptjm-71	48	20	found	find	VERB
bptjm-71	48	21	to	to	PART
bptjm-71	48	22	hinder	hinder	VERB
bptjm-71	48	23	signaling	signal	VERB
bptjm-71	48	24	and	and	CCONJ
bptjm-71	48	25	lead	lead	VERB
bptjm-71	48	26	to	to	ADP
bptjm-71	48	27	the	the	DET
bptjm-71	48	28	repression	repression	NOUN
bptjm-71	48	29	of	of	ADP
bptjm-71	48	30	the	the	DET
bptjm-71	48	31	neuron	neuron	NOUN
bptjm-71	48	32	’s	’s	PART
bptjm-71	48	33	axonal	axonal	ADJ
bptjm-71	48	34	regeneration	regeneration	NOUN
bptjm-71	48	35	capabilities	capability	NOUN
bptjm-71	48	36	.	.	PUNCT
bptjm-71	49	1	however	however	ADV
bptjm-71	49	2	,	,	PUNCT
bptjm-71	49	3	the	the	DET
bptjm-71	49	4	same	same	ADJ
bptjm-71	49	5	study	study	NOUN
bptjm-71	49	6	showed	show	VERB
bptjm-71	49	7	that	that	SCONJ
bptjm-71	49	8	regenerative	regenerative	ADJ
bptjm-71	49	9	failure	failure	NOUN
bptjm-71	49	10	in	in	ADP
bptjm-71	49	11	drg	drg	NOUN
bptjm-71	49	12	could	could	AUX
bptjm-71	49	13	be	be	AUX
bptjm-71	49	14	restored	restore	VERB
bptjm-71	49	15	by	by	ADP
bptjm-71	49	16	the	the	DET
bptjm-71	49	17	neutralization	neutralization	NOUN
bptjm-71	49	18	of	of	ADP
bptjm-71	49	19	chemokine	chemokine	ADJ
bptjm-71	49	20	cxcl13	cxcl13	NOUN
bptjm-71	49	21	with	with	ADP
bptjm-71	49	22	monoclonal	monoclonal	NOUN
bptjm-71	49	23	antibodies.12	antibodies.12	NOUN
bptjm-71	49	24	similarly	similarly	ADV
bptjm-71	49	25	,	,	PUNCT
bptjm-71	49	26	myelin	myelin	NOUN
bptjm-71	49	27	injury	injury	NOUN
bptjm-71	49	28	and	and	CCONJ
bptjm-71	49	29	regenerative	regenerative	ADJ
bptjm-71	49	30	failure	failure	NOUN
bptjm-71	49	31	can	can	AUX
bptjm-71	49	32	occur	occur	VERB
bptjm-71	49	33	if	if	SCONJ
bptjm-71	49	34	sasp	sasp	NOUN
bptjm-71	49	35	is	be	AUX
bptjm-71	49	36	activated	activate	VERB
bptjm-71	49	37	in	in	ADP
bptjm-71	49	38	olgs.13	olgs.13	PROPN
bptjm-71	49	39	a	a	DET
bptjm-71	49	40	study	study	NOUN
bptjm-71	49	41	with	with	ADP
bptjm-71	49	42	mice	mouse	NOUN
bptjm-71	49	43	showed	show	VERB
bptjm-71	49	44	that	that	SCONJ
bptjm-71	49	45	persistent	persistent	ADJ
bptjm-71	49	46	nf	nf	ADJ
bptjm-71	49	47	-	-	PUNCT
bptjm-71	49	48	κb	κb	NOUN
bptjm-71	49	49	signaling	signal	VERB
bptjm-71	49	50	in	in	ADP
bptjm-71	49	51	olgs	olgs	NOUN
bptjm-71	49	52	led	lead	VERB
bptjm-71	49	53	to	to	ADP
bptjm-71	49	54	chronic	chronic	ADJ
bptjm-71	49	55	neuroinflammation	neuroinflammation	NOUN
bptjm-71	49	56	and	and	CCONJ
bptjm-71	49	57	post	post	ADJ
bptjm-71	49	58	-	-	ADJ
bptjm-71	49	59	mitotic	mitotic	ADJ
bptjm-71	49	60	senescence	senescence	NOUN
bptjm-71	49	61	.	.	PUNCT
bptjm-71	50	1	nf	nf	X
bptjm-71	50	2	-	-	PUNCT
bptjm-71	50	3	κb	κb	NOUN
bptjm-71	50	4	signaling	signal	VERB
bptjm-71	50	5	also	also	ADV
bptjm-71	50	6	promoted	promote	VERB
bptjm-71	50	7	white	white	ADJ
bptjm-71	50	8	matter	matter	NOUN
bptjm-71	50	9	degeneration	degeneration	NOUN
bptjm-71	50	10	(	(	PUNCT
bptjm-71	50	11	wmd	wmd	PROPN
bptjm-71	50	12	)	)	PUNCT
bptjm-71	50	13	in	in	ADP
bptjm-71	50	14	the	the	DET
bptjm-71	50	15	brain	brain	NOUN
bptjm-71	50	16	,	,	PUNCT
bptjm-71	50	17	a	a	DET
bptjm-71	50	18	well	well	ADV
bptjm-71	50	19	-	-	PUNCT
bptjm-71	50	20	known	know	VERB
bptjm-71	50	21	process	process	NOUN
bptjm-71	50	22	of	of	ADP
bptjm-71	50	23	aging	aging	NOUN
bptjm-71	50	24	.	.	PUNCT
bptjm-71	51	1	wmd	wmd	PROPN
bptjm-71	51	2	often	often	ADV
bptjm-71	51	3	manifests	manifest	VERB
bptjm-71	51	4	in	in	ADP
bptjm-71	51	5	myelin	myelin	ADJ
bptjm-71	51	6	loss	loss	NOUN
bptjm-71	51	7	,	,	PUNCT
bptjm-71	51	8	which	which	PRON
bptjm-71	51	9	was	be	AUX
bptjm-71	51	10	confirmed	confirm	VERB
bptjm-71	51	11	by	by	ADP
bptjm-71	51	12	ultrastructural	ultrastructural	ADJ
bptjm-71	51	13	analysis	analysis	NOUN
bptjm-71	51	14	of	of	ADP
bptjm-71	51	15	the	the	DET
bptjm-71	51	16	mice	mouse	NOUN
bptjm-71	51	17	that	that	PRON
bptjm-71	51	18	revealed	reveal	VERB
bptjm-71	51	19	impaired	impaired	ADJ
bptjm-71	51	20	myelin	myelin	ADJ
bptjm-71	51	21	protein	protein	NOUN
bptjm-71	51	22	expression	expression	NOUN
bptjm-71	51	23	.	.	PUNCT
bptjm-71	52	1	additionally	additionally	ADV
bptjm-71	52	2	,	,	PUNCT
bptjm-71	52	3	the	the	DET
bptjm-71	52	4	mice	mouse	NOUN
bptjm-71	52	5	exhibited	exhibit	VERB
bptjm-71	52	6	neurological	neurological	ADJ
bptjm-71	52	7	deficits	deficit	NOUN
bptjm-71	52	8	within	within	ADP
bptjm-71	52	9	three	three	NUM
bptjm-71	52	10	weeks	week	NOUN
bptjm-71	52	11	following	follow	VERB
bptjm-71	52	12	treatment.14	treatment.14	DET
bptjm-71	52	13	olgs	olgs	NOUN
bptjm-71	52	14	have	have	AUX
bptjm-71	52	15	also	also	ADV
bptjm-71	52	16	been	be	AUX
bptjm-71	52	17	found	find	VERB
bptjm-71	52	18	to	to	PART
bptjm-71	52	19	be	be	AUX
bptjm-71	52	20	affected	affect	VERB
bptjm-71	52	21	by	by	ADP
bptjm-71	52	22	secretion	secretion	NOUN
bptjm-71	52	23	factor	factor	NOUN
bptjm-71	52	24	high	high	ADJ
bptjm-71	52	25	-	-	PUNCT
bptjm-71	52	26	mobility	mobility	NOUN
bptjm-71	52	27	group	group	NOUN
bptjm-71	52	28	box-1	box-1	ADJ
bptjm-71	52	29	(	(	PUNCT
bptjm-71	52	30	hmgb1	hmgb1	PROPN
bptjm-71	52	31	)	)	PUNCT
bptjm-71	52	32	in	in	ADP
bptjm-71	52	33	vivo	vivo	NOUN
bptjm-71	52	34	.	.	PUNCT
bptjm-71	53	1	when	when	SCONJ
bptjm-71	53	2	extracellular	extracellular	ADJ
bptjm-71	53	3	hmgb1	hmgb1	PROPN
bptjm-71	53	4	was	be	AUX
bptjm-71	53	5	released	release	VERB
bptjm-71	53	6	by	by	ADP
bptjm-71	53	7	senescent	senescent	ADJ
bptjm-71	53	8	progenitor	progenitor	NOUN
bptjm-71	53	9	cells	cell	NOUN
bptjm-71	53	10	,	,	PUNCT
bptjm-71	53	11	differentiation	differentiation	NOUN
bptjm-71	53	12	of	of	ADP
bptjm-71	53	13	opcs	opc	NOUN
bptjm-71	53	14	to	to	ADP
bptjm-71	53	15	myelinating	myelinate	VERB
bptjm-71	53	16	olgs	olgs	NOUN
bptjm-71	53	17	was	be	AUX
bptjm-71	53	18	prevented	prevent	VERB
bptjm-71	53	19	,	,	PUNCT
bptjm-71	53	20	ultimately	ultimately	ADV
bptjm-71	53	21	inhibiting	inhibit	VERB
bptjm-71	53	22	cns	cns	NOUN
bptjm-71	53	23	remyelination.15	remyelination.15	NOUN
bptjm-71	53	24	moreover	moreover	ADV
bptjm-71	53	25	,	,	PUNCT
bptjm-71	53	26	hmgb1	hmgb1	PROPN
bptjm-71	53	27	prevailed	prevail	VERB
bptjm-71	53	28	at	at	ADP
bptjm-71	53	29	higher	high	ADJ
bptjm-71	53	30	levels	level	NOUN
bptjm-71	53	31	in	in	ADP
bptjm-71	53	32	the	the	DET
bptjm-71	53	33	brains	brain	NOUN
bptjm-71	53	34	of	of	ADP
bptjm-71	53	35	patients	patient	NOUN
bptjm-71	53	36	with	with	ADP
bptjm-71	53	37	primary	primary	ADJ
bptjm-71	53	38	progressive	progressive	ADJ
bptjm-71	53	39	multiple	multiple	ADJ
bptjm-71	53	40	sclerosis	sclerosis	NOUN
bptjm-71	53	41	(	(	PUNCT
bptjm-71	53	42	ppms	ppm	NOUN
bptjm-71	53	43	)	)	PUNCT
bptjm-71	53	44	compared	compare	VERB
bptjm-71	53	45	to	to	ADP
bptjm-71	53	46	healthy	healthy	ADJ
bptjm-71	53	47	controls	control	NOUN
bptjm-71	53	48	.	.	PUNCT
bptjm-71	54	1	more	more	ADV
bptjm-71	54	2	specifically	specifically	ADV
bptjm-71	54	3	,	,	PUNCT
bptjm-71	54	4	hmgb1	hmgb1	PROPN
bptjm-71	54	5	was	be	AUX
bptjm-71	54	6	found	find	VERB
bptjm-71	54	7	at	at	ADP
bptjm-71	54	8	high	high	ADJ
bptjm-71	54	9	concentrations	concentration	NOUN
bptjm-71	54	10	in	in	ADP
bptjm-71	54	11	white	white	ADJ
bptjm-71	54	12	matter	matter	NOUN
bptjm-71	54	13	lesions	lesion	NOUN
bptjm-71	54	14	of	of	ADP
bptjm-71	54	15	the	the	DET
bptjm-71	54	16	brain	brain	NOUN
bptjm-71	54	17	,	,	PUNCT
bptjm-71	54	18	and	and	CCONJ
bptjm-71	54	19	progenitor	progenitor	NOUN
bptjm-71	54	20	cells	cell	NOUN
bptjm-71	54	21	were	be	AUX
bptjm-71	54	22	identified	identify	VERB
bptjm-71	54	23	to	to	PART
bptjm-71	54	24	be	be	AUX
bptjm-71	54	25	the	the	DET
bptjm-71	54	26	source.16	source.16	PROPN
bptjm-71	54	27	this	this	PRON
bptjm-71	54	28	highlights	highlight	VERB
bptjm-71	54	29	the	the	DET
bptjm-71	54	30	contributing	contribute	VERB
bptjm-71	54	31	role	role	NOUN
bptjm-71	54	32	of	of	ADP
bptjm-71	54	33	sasp	sasp	NOUN
bptjm-71	54	34	factor	factor	NOUN
bptjm-71	54	35	hmgb1	hmgb1	NOUN
bptjm-71	54	36	in	in	ADP
bptjm-71	54	37	the	the	DET
bptjm-71	54	38	limited	limited	ADJ
bptjm-71	54	39	remyelination	remyelination	NOUN
bptjm-71	54	40	found	find	VERB
bptjm-71	54	41	in	in	ADP
bptjm-71	54	42	ppms	ppm	NOUN
bptjm-71	54	43	,	,	PUNCT
bptjm-71	54	44	as	as	ADV
bptjm-71	54	45	well	well	ADV
bptjm-71	54	46	as	as	ADP
bptjm-71	54	47	potentially	potentially	ADV
bptjm-71	54	48	other	other	ADJ
bptjm-71	54	49	neurodegenerative	neurodegenerative	ADJ
bptjm-71	54	50	diseases	disease	NOUN
bptjm-71	54	51	.	.	PUNCT
bptjm-71	55	1	examples	example	NOUN
bptjm-71	55	2	of	of	ADP
bptjm-71	55	3	other	other	ADJ
bptjm-71	55	4	neurotoxic	neurotoxic	ADJ
bptjm-71	55	5	sasp	sasp	NOUN
bptjm-71	55	6	factors	factor	NOUN
bptjm-71	55	7	include	include	VERB
bptjm-71	55	8	il-8	il-8	NOUN
bptjm-71	55	9	,	,	PUNCT
bptjm-71	55	10	il-1	il-1	NUM
bptjm-71	55	11	,	,	PUNCT
bptjm-71	55	12	matrix	matrix	NOUN
bptjm-71	55	13	metalloproteinases	metalloproteinase	NOUN
bptjm-71	55	14	,	,	PUNCT
bptjm-71	55	15	insulin	insulin	NOUN
bptjm-71	55	16	-	-	PUNCT
bptjm-71	55	17	like	like	ADJ
bptjm-71	55	18	growth	growth	NOUN
bptjm-71	55	19	factors	factor	NOUN
bptjm-71	55	20	(	(	PUNCT
bptjm-71	55	21	igfs	igfs	NOUN
bptjm-71	55	22	)	)	PUNCT
bptjm-71	55	23	,	,	PUNCT
bptjm-71	55	24	endothelial	endothelial	ADJ
bptjm-71	55	25	growth	growth	NOUN
bptjm-71	55	26	berkeley	berkeley	PROPN
bptjm-71	55	27	pharma	pharma	PROPN
bptjm-71	55	28	tech	tech	NOUN
bptjm-71	55	29	journal	journal	NOUN
bptjm-71	55	30	of	of	ADP
bptjm-71	55	31	medicine	medicine	NOUN
bptjm-71	55	32	|	|	ADV
bptjm-71	55	33	48	48	NUM
bptjm-71	55	34	factor	factor	NOUN
bptjm-71	55	35	(	(	PUNCT
bptjm-71	55	36	egf	egf	PROPN
bptjm-71	55	37	)	)	PUNCT
bptjm-71	55	38	,	,	PUNCT
bptjm-71	55	39	epidermal	epidermal	ADJ
bptjm-71	55	40	growth	growth	NOUN
bptjm-71	55	41	factor	factor	NOUN
bptjm-71	55	42	receptor	receptor	NOUN
bptjm-71	55	43	(	(	PUNCT
bptjm-71	55	44	egfr	egfr	NOUN
bptjm-71	55	45	)	)	PUNCT
bptjm-71	55	46	,	,	PUNCT
bptjm-71	55	47	specific	specific	ADJ
bptjm-71	55	48	mirnas	mirna	NOUN
bptjm-71	55	49	,	,	PUNCT
bptjm-71	55	50	and	and	CCONJ
bptjm-71	55	51	many	many	ADJ
bptjm-71	55	52	other	other	ADJ
bptjm-71	55	53	molecules.7	molecules.7	AUX
bptjm-71	55	54	2.2	2.2	NUM
bptjm-71	55	55	biomarkers	biomarker	NOUN
bptjm-71	55	56	understanding	understand	VERB
bptjm-71	55	57	the	the	DET
bptjm-71	55	58	relationship	relationship	NOUN
bptjm-71	55	59	between	between	ADP
bptjm-71	55	60	cellular	cellular	ADJ
bptjm-71	55	61	senescence	senescence	NOUN
bptjm-71	55	62	and	and	CCONJ
bptjm-71	55	63	neurodegenerative	neurodegenerative	ADJ
bptjm-71	55	64	conditions	condition	NOUN
bptjm-71	55	65	is	be	AUX
bptjm-71	55	66	crucial	crucial	ADJ
bptjm-71	55	67	for	for	ADP
bptjm-71	55	68	developing	develop	VERB
bptjm-71	55	69	effective	effective	ADJ
bptjm-71	55	70	therapeutic	therapeutic	ADJ
bptjm-71	55	71	strategies	strategy	NOUN
bptjm-71	55	72	.	.	PUNCT
bptjm-71	56	1	to	to	ADP
bptjm-71	56	2	this	this	DET
bptjm-71	56	3	end	end	NOUN
bptjm-71	56	4	,	,	PUNCT
bptjm-71	56	5	researchers	researcher	NOUN
bptjm-71	56	6	have	have	AUX
bptjm-71	56	7	focused	focus	VERB
bptjm-71	56	8	on	on	ADP
bptjm-71	56	9	identifying	identify	VERB
bptjm-71	56	10	biomarkers	biomarker	NOUN
bptjm-71	56	11	that	that	PRON
bptjm-71	56	12	link	link	VERB
bptjm-71	56	13	cellular	cellular	ADJ
bptjm-71	56	14	senescence	senescence	NOUN
bptjm-71	56	15	to	to	ADP
bptjm-71	56	16	neurodegeneration	neurodegeneration	NOUN
bptjm-71	56	17	.	.	PUNCT
bptjm-71	57	1	several	several	ADJ
bptjm-71	57	2	enzymes	enzyme	NOUN
bptjm-71	57	3	,	,	PUNCT
bptjm-71	57	4	cytokines	cytokine	NOUN
bptjm-71	57	5	,	,	PUNCT
bptjm-71	57	6	chemokines	chemokine	NOUN
bptjm-71	57	7	,	,	PUNCT
bptjm-71	57	8	genes	gene	NOUN
bptjm-71	57	9	,	,	PUNCT
bptjm-71	57	10	and	and	CCONJ
bptjm-71	57	11	other	other	ADJ
bptjm-71	57	12	biomarkers	biomarker	NOUN
bptjm-71	57	13	have	have	AUX
bptjm-71	57	14	been	be	AUX
bptjm-71	57	15	implicated	implicate	VERB
bptjm-71	57	16	in	in	ADP
bptjm-71	57	17	senescence	senescence	NOUN
bptjm-71	57	18	-	-	PUNCT
bptjm-71	57	19	related	relate	VERB
bptjm-71	57	20	processes	process	NOUN
bptjm-71	57	21	in	in	ADP
bptjm-71	57	22	the	the	DET
bptjm-71	57	23	brain	brain	NOUN
bptjm-71	57	24	.	.	PUNCT
bptjm-71	58	1	these	these	DET
bptjm-71	58	2	biomarkers	biomarker	NOUN
bptjm-71	58	3	provide	provide	VERB
bptjm-71	58	4	valuable	valuable	ADJ
bptjm-71	58	5	insights	insight	NOUN
bptjm-71	58	6	into	into	ADP
bptjm-71	58	7	the	the	DET
bptjm-71	58	8	mechanisms	mechanism	NOUN
bptjm-71	58	9	underlying	underlie	VERB
bptjm-71	58	10	neurodegenerative	neurodegenerative	ADJ
bptjm-71	58	11	diseases	disease	NOUN
bptjm-71	58	12	and	and	CCONJ
bptjm-71	58	13	offer	offer	VERB
bptjm-71	58	14	potential	potential	ADJ
bptjm-71	58	15	targets	target	NOUN
bptjm-71	58	16	for	for	ADP
bptjm-71	58	17	therapeutic	therapeutic	ADJ
bptjm-71	58	18	interventions	intervention	NOUN
bptjm-71	58	19	.	.	PUNCT
bptjm-71	59	1	enzymes	enzyme	NOUN
bptjm-71	59	2	●	●	NUM
bptjm-71	59	3	senescence	senescence	NOUN
bptjm-71	59	4	-	-	PUNCT
bptjm-71	59	5	associated	associate	VERB
bptjm-71	59	6	beta	beta	NOUN
bptjm-71	59	7	-	-	PUNCT
bptjm-71	59	8	galactosidase	galactosidase	NOUN
bptjm-71	59	9	(	(	PUNCT
bptjm-71	59	10	sa	sa	NOUN
bptjm-71	59	11	-	-	PUNCT
bptjm-71	59	12	β	β	NOUN
bptjm-71	59	13	-	-	ADJ
bptjm-71	59	14	gal	gal	ADJ
bptjm-71	59	15	):	):	PUNCT
bptjm-71	59	16	sa	sa	PROPN
bptjm-71	59	17	-	-	PUNCT
bptjm-71	59	18	β	β	NOUN
bptjm-71	59	19	-	-	ADJ
bptjm-71	59	20	gal	gal	ADJ
bptjm-71	59	21	is	be	AUX
bptjm-71	59	22	one	one	NUM
bptjm-71	59	23	of	of	ADP
bptjm-71	59	24	the	the	DET
bptjm-71	59	25	earliest	early	ADJ
bptjm-71	59	26	markers	marker	NOUN
bptjm-71	59	27	identified	identify	VERB
bptjm-71	59	28	for	for	ADP
bptjm-71	59	29	the	the	DET
bptjm-71	59	30	detection	detection	NOUN
bptjm-71	59	31	of	of	ADP
bptjm-71	59	32	senescent	senescent	ADJ
bptjm-71	59	33	cells	cell	NOUN
bptjm-71	59	34	in	in	ADP
bptjm-71	59	35	situ	situ	NOUN
bptjm-71	59	36	within	within	ADP
bptjm-71	59	37	tissues.7	tissues.7	NOUN
bptjm-71	59	38	this	this	DET
bptjm-71	59	39	hydrolytic	hydrolytic	ADJ
bptjm-71	59	40	enzyme	enzyme	NOUN
bptjm-71	59	41	becomes	become	VERB
bptjm-71	59	42	active	active	ADJ
bptjm-71	59	43	in	in	ADP
bptjm-71	59	44	senescent	senescent	ADJ
bptjm-71	59	45	cells	cell	NOUN
bptjm-71	59	46	and	and	CCONJ
bptjm-71	59	47	is	be	AUX
bptjm-71	59	48	commonly	commonly	ADV
bptjm-71	59	49	used	use	VERB
bptjm-71	59	50	as	as	ADP
bptjm-71	59	51	a	a	DET
bptjm-71	59	52	hallmark	hallmark	NOUN
bptjm-71	59	53	to	to	PART
bptjm-71	59	54	distinguish	distinguish	VERB
bptjm-71	59	55	senescent	senescent	ADJ
bptjm-71	59	56	cells	cell	NOUN
bptjm-71	59	57	from	from	ADP
bptjm-71	59	58	non	non	ADJ
bptjm-71	59	59	-	-	ADJ
bptjm-71	59	60	senescent	senescent	ADJ
bptjm-71	59	61	cells	cell	NOUN
bptjm-71	59	62	.	.	PUNCT
bptjm-71	60	1	●	●	PUNCT
bptjm-71	60	2	caspase	caspase	NOUN
bptjm-71	60	3	3	3	NUM
bptjm-71	60	4	:	:	PUNCT
bptjm-71	60	5	caspase	caspase	NOUN
bptjm-71	60	6	3	3	NUM
bptjm-71	60	7	is	be	AUX
bptjm-71	60	8	an	an	DET
bptjm-71	60	9	enzyme	enzyme	NOUN
bptjm-71	60	10	involved	involve	VERB
bptjm-71	60	11	in	in	ADP
bptjm-71	60	12	apoptosis	apoptosis	NOUN
bptjm-71	60	13	.	.	PUNCT
bptjm-71	61	1	it	it	PRON
bptjm-71	61	2	suggests	suggest	VERB
bptjm-71	61	3	a	a	DET
bptjm-71	61	4	potential	potential	ADJ
bptjm-71	61	5	link	link	NOUN
bptjm-71	61	6	between	between	ADP
bptjm-71	61	7	senescence	senescence	NOUN
bptjm-71	61	8	and	and	CCONJ
bptjm-71	61	9	cell	cell	NOUN
bptjm-71	61	10	death	death	NOUN
bptjm-71	61	11	pathways.18	pathways.18	NOUN
bptjm-71	61	12	cytokines	cytokine	VERB
bptjm-71	61	13	cytokines	cytokine	NOUN
bptjm-71	61	14	are	be	AUX
bptjm-71	61	15	signaling	signal	VERB
bptjm-71	61	16	molecules	molecule	NOUN
bptjm-71	61	17	that	that	PRON
bptjm-71	61	18	play	play	VERB
bptjm-71	61	19	critical	critical	ADJ
bptjm-71	61	20	roles	role	NOUN
bptjm-71	61	21	in	in	ADP
bptjm-71	61	22	inflammation	inflammation	NOUN
bptjm-71	61	23	and	and	CCONJ
bptjm-71	61	24	immune	immune	ADJ
bptjm-71	61	25	responses	response	NOUN
bptjm-71	61	26	.	.	PUNCT
bptjm-71	62	1	certain	certain	ADJ
bptjm-71	62	2	cytokines	cytokine	NOUN
bptjm-71	62	3	have	have	AUX
bptjm-71	62	4	been	be	AUX
bptjm-71	62	5	found	find	VERB
bptjm-71	62	6	to	to	PART
bptjm-71	62	7	be	be	AUX
bptjm-71	62	8	associated	associate	VERB
bptjm-71	62	9	with	with	ADP
bptjm-71	62	10	the	the	DET
bptjm-71	62	11	development	development	NOUN
bptjm-71	62	12	of	of	ADP
bptjm-71	62	13	neurodegeneration	neurodegeneration	NOUN
bptjm-71	62	14	.	.	PUNCT
bptjm-71	63	1	●	●	PUNCT
bptjm-71	63	2	il27	il27	NOUN
bptjm-71	63	3	:	:	PUNCT
bptjm-71	63	4	this	this	DET
bptjm-71	63	5	cytokine	cytokine	NOUN
bptjm-71	63	6	is	be	AUX
bptjm-71	63	7	involved	involve	VERB
bptjm-71	63	8	in	in	ADP
bptjm-71	63	9	the	the	DET
bptjm-71	63	10	activation	activation	NOUN
bptjm-71	63	11	of	of	ADP
bptjm-71	63	12	natural	natural	ADJ
bptjm-71	63	13	killer	killer	NOUN
bptjm-71	63	14	cells	cell	NOUN
bptjm-71	63	15	in	in	ADP
bptjm-71	63	16	the	the	DET
bptjm-71	63	17	dentate	dentate	ADJ
bptjm-71	63	18	gyrus	gyrus	NOUN
bptjm-71	63	19	,	,	PUNCT
bptjm-71	63	20	which	which	PRON
bptjm-71	63	21	leads	lead	VERB
bptjm-71	63	22	to	to	ADP
bptjm-71	63	23	the	the	DET
bptjm-71	63	24	elimination	elimination	NOUN
bptjm-71	63	25	of	of	ADP
bptjm-71	63	26	neuroblasts	neuroblast	NOUN
bptjm-71	63	27	and	and	CCONJ
bptjm-71	63	28	subsequently	subsequently	ADV
bptjm-71	63	29	contributes	contribute	VERB
bptjm-71	63	30	to	to	ADP
bptjm-71	63	31	neurodegeneration	neurodegeneration	NOUN
bptjm-71	63	32	and	and	CCONJ
bptjm-71	63	33	cognitive	cognitive	ADJ
bptjm-71	63	34	decline.19	decline.19	NOUN
bptjm-71	63	35	●	●	NOUN
bptjm-71	63	36	il-6	il-6	NUM
bptjm-71	63	37	,	,	PUNCT
bptjm-71	63	38	il-8	il-8	NOUN
bptjm-71	63	39	,	,	PUNCT
bptjm-71	63	40	il-1β	il-1β	PROPN
bptjm-71	63	41	:	:	PUNCT
bptjm-71	63	42	il-6	il-6	NUM
bptjm-71	63	43	,	,	PUNCT
bptjm-71	63	44	il-8	il-8	NOUN
bptjm-71	63	45	,	,	PUNCT
bptjm-71	63	46	and	and	CCONJ
bptjm-71	63	47	il-1β	il-1β	PROPN
bptjm-71	63	48	are	be	AUX
bptjm-71	63	49	among	among	ADP
bptjm-71	63	50	the	the	DET
bptjm-71	63	51	cytokines	cytokine	NOUN
bptjm-71	63	52	that	that	PRON
bptjm-71	63	53	mediate	mediate	VERB
bptjm-71	63	54	tumor	tumor	NOUN
bptjm-71	63	55	suppressor	suppressor	NOUN
bptjm-71	63	56	functions	function	NOUN
bptjm-71	63	57	.	.	PUNCT
bptjm-71	64	1	studies	study	NOUN
bptjm-71	64	2	conducted	conduct	VERB
bptjm-71	64	3	by	by	ADP
bptjm-71	64	4	bussian	bussian	PROPN
bptjm-71	64	5	et	et	PROPN
bptjm-71	64	6	al	al	PROPN
bptjm-71	64	7	.	.	PROPN
bptjm-71	64	8	andmusi	andmusi	PROPN
bptjm-71	64	9	et	et	PROPN
bptjm-71	64	10	al	al	PROPN
bptjm-71	64	11	.	.	PROPN
bptjm-71	64	12	have	have	AUX
bptjm-71	64	13	identified	identify	VERB
bptjm-71	64	14	these	these	DET
bptjm-71	64	15	cytokines	cytokine	NOUN
bptjm-71	64	16	in	in	ADP
bptjm-71	64	17	the	the	DET
bptjm-71	64	18	brains	brain	NOUN
bptjm-71	64	19	of	of	ADP
bptjm-71	64	20	mouse	mouse	NOUN
bptjm-71	64	21	models	model	NOUN
bptjm-71	64	22	with	with	ADP
bptjm-71	64	23	tauopathy	tauopathy	NOUN
bptjm-71	64	24	.	.	PUNCT
bptjm-71	65	1	they	they	PRON
bptjm-71	65	2	were	be	AUX
bptjm-71	65	3	found	find	VERB
bptjm-71	65	4	to	to	PART
bptjm-71	65	5	be	be	AUX
bptjm-71	65	6	part	part	NOUN
bptjm-71	65	7	of	of	ADP
bptjm-71	65	8	the	the	DET
bptjm-71	65	9	sasps	sasp	NOUN
bptjm-71	65	10	observed	observe	VERB
bptjm-71	65	11	in	in	ADP
bptjm-71	65	12	these	these	DET
bptjm-71	65	13	models.20,21	models.20,21	NOUN
bptjm-71	65	14	berkeley	berkeley	PROPN
bptjm-71	65	15	pharma	pharma	PROPN
bptjm-71	65	16	tech	tech	NOUN
bptjm-71	65	17	journal	journal	NOUN
bptjm-71	65	18	of	of	ADP
bptjm-71	65	19	medicine	medicine	NOUN
bptjm-71	65	20	|	|	ADV
bptjm-71	65	21	49	49	NUM
bptjm-71	65	22	chemokines	chemokine	NOUN
bptjm-71	65	23	chemokines	chemokine	NOUN
bptjm-71	65	24	are	be	AUX
bptjm-71	65	25	small	small	ADJ
bptjm-71	65	26	signaling	signal	VERB
bptjm-71	65	27	proteins	protein	NOUN
bptjm-71	65	28	involved	involve	VERB
bptjm-71	65	29	in	in	ADP
bptjm-71	65	30	cellular	cellular	ADJ
bptjm-71	65	31	migration	migration	NOUN
bptjm-71	65	32	and	and	CCONJ
bptjm-71	65	33	immune	immune	ADJ
bptjm-71	65	34	responses	response	NOUN
bptjm-71	65	35	.	.	PUNCT
bptjm-71	66	1	one	one	NUM
bptjm-71	66	2	chemokine	chemokine	ADJ
bptjm-71	66	3	that	that	PRON
bptjm-71	66	4	has	have	AUX
bptjm-71	66	5	been	be	AUX
bptjm-71	66	6	linked	link	VERB
bptjm-71	66	7	to	to	ADP
bptjm-71	66	8	senescence	senescence	NOUN
bptjm-71	66	9	-	-	PUNCT
bptjm-71	66	10	associated	associate	VERB
bptjm-71	66	11	neurodegeneration	neurodegeneration	NOUN
bptjm-71	66	12	is	be	AUX
bptjm-71	66	13	ccl2.22	ccl2.22	PROPN
bptjm-71	66	14	●	●	NUM
bptjm-71	66	15	ccl2	ccl2	NOUN
bptjm-71	66	16	:	:	PUNCT
bptjm-71	66	17	studies	study	NOUN
bptjm-71	66	18	have	have	AUX
bptjm-71	66	19	implicated	implicate	VERB
bptjm-71	66	20	ccl2	ccl2	NOUN
bptjm-71	66	21	in	in	ADP
bptjm-71	66	22	the	the	DET
bptjm-71	66	23	development	development	NOUN
bptjm-71	66	24	of	of	ADP
bptjm-71	66	25	neurodegenerative	neurodegenerative	ADJ
bptjm-71	66	26	processes	process	NOUN
bptjm-71	66	27	.	.	PUNCT
bptjm-71	67	1	it	it	PRON
bptjm-71	67	2	may	may	AUX
bptjm-71	67	3	contribute	contribute	VERB
bptjm-71	67	4	to	to	ADP
bptjm-71	67	5	the	the	DET
bptjm-71	67	6	recruitment	recruitment	NOUN
bptjm-71	67	7	of	of	ADP
bptjm-71	67	8	immune	immune	ADJ
bptjm-71	67	9	cells	cell	NOUN
bptjm-71	67	10	,	,	PUNCT
bptjm-71	67	11	such	such	ADJ
bptjm-71	67	12	as	as	ADP
bptjm-71	67	13	microglia	microglia	NOUN
bptjm-71	67	14	,	,	PUNCT
bptjm-71	67	15	to	to	ADP
bptjm-71	67	16	the	the	DET
bptjm-71	67	17	site	site	NOUN
bptjm-71	67	18	of	of	ADP
bptjm-71	67	19	neurodegeneration	neurodegeneration	NOUN
bptjm-71	67	20	,	,	PUNCT
bptjm-71	67	21	further	far	ADV
bptjm-71	67	22	promoting	promote	VERB
bptjm-71	67	23	inflammation	inflammation	NOUN
bptjm-71	67	24	and	and	CCONJ
bptjm-71	67	25	tissue	tissue	NOUN
bptjm-71	67	26	damage.23	damage.23	PROPN
bptjm-71	67	27	apart	apart	ADV
bptjm-71	67	28	from	from	ADP
bptjm-71	67	29	its	its	PRON
bptjm-71	67	30	role	role	NOUN
bptjm-71	67	31	in	in	ADP
bptjm-71	67	32	immune	immune	ADJ
bptjm-71	67	33	cell	cell	NOUN
bptjm-71	67	34	recruitment	recruitment	NOUN
bptjm-71	67	35	,	,	PUNCT
bptjm-71	67	36	ccl2	ccl2	PROPN
bptjm-71	67	37	can	can	AUX
bptjm-71	67	38	also	also	ADV
bptjm-71	67	39	directly	directly	ADV
bptjm-71	67	40	influence	influence	VERB
bptjm-71	67	41	neuronal	neuronal	ADJ
bptjm-71	67	42	function	function	NOUN
bptjm-71	67	43	.	.	PUNCT
bptjm-71	68	1	it	it	PRON
bptjm-71	68	2	has	have	AUX
bptjm-71	68	3	been	be	AUX
bptjm-71	68	4	suggested	suggest	VERB
bptjm-71	68	5	that	that	SCONJ
bptjm-71	68	6	ccl2	ccl2	PROPN
bptjm-71	68	7	might	might	AUX
bptjm-71	68	8	affect	affect	VERB
bptjm-71	68	9	synaptic	synaptic	ADJ
bptjm-71	68	10	plasticity	plasticity	NOUN
bptjm-71	68	11	and	and	CCONJ
bptjm-71	68	12	neurotransmission	neurotransmission	NOUN
bptjm-71	68	13	,	,	PUNCT
bptjm-71	68	14	potentially	potentially	ADV
bptjm-71	68	15	contributing	contribute	VERB
bptjm-71	68	16	to	to	ADP
bptjm-71	68	17	cognitive	cognitive	ADJ
bptjm-71	68	18	and	and	CCONJ
bptjm-71	68	19	functional	functional	ADJ
bptjm-71	68	20	impairments	impairment	NOUN
bptjm-71	68	21	seen	see	VERB
bptjm-71	68	22	in	in	ADP
bptjm-71	68	23	neurodegenerative	neurodegenerative	ADJ
bptjm-71	68	24	diseases.22	diseases.22	NOUN
bptjm-71	68	25	genes	gene	NOUN
bptjm-71	68	26	several	several	ADJ
bptjm-71	68	27	genes	gene	NOUN
bptjm-71	68	28	have	have	AUX
bptjm-71	68	29	been	be	AUX
bptjm-71	68	30	identified	identify	VERB
bptjm-71	68	31	as	as	ADP
bptjm-71	68	32	crucial	crucial	ADJ
bptjm-71	68	33	regulators	regulator	NOUN
bptjm-71	68	34	of	of	ADP
bptjm-71	68	35	cellular	cellular	ADJ
bptjm-71	68	36	senescence	senescence	NOUN
bptjm-71	68	37	,	,	PUNCT
bptjm-71	68	38	and	and	CCONJ
bptjm-71	68	39	their	their	PRON
bptjm-71	68	40	dysregulation	dysregulation	NOUN
bptjm-71	68	41	may	may	AUX
bptjm-71	68	42	contribute	contribute	VERB
bptjm-71	68	43	to	to	ADP
bptjm-71	68	44	neurodegeneration	neurodegeneration	NOUN
bptjm-71	68	45	.	.	PUNCT
bptjm-71	69	1	●	●	PUNCT
bptjm-71	69	2	p16	p16	NOUN
bptjm-71	69	3	,	,	PUNCT
bptjm-71	69	4	p21	p21	NOUN
bptjm-71	69	5	,	,	PUNCT
bptjm-71	69	6	p53	p53	NOUN
bptjm-71	69	7	:	:	PUNCT
bptjm-71	69	8	these	these	DET
bptjm-71	69	9	genes	gene	NOUN
bptjm-71	69	10	encode	encode	ADJ
bptjm-71	69	11	cell	cell	NOUN
bptjm-71	69	12	cycle	cycle	NOUN
bptjm-71	69	13	inhibitors	inhibitor	NOUN
bptjm-71	69	14	and	and	CCONJ
bptjm-71	69	15	repressors	repressor	NOUN
bptjm-71	69	16	and	and	CCONJ
bptjm-71	69	17	are	be	AUX
bptjm-71	69	18	essential	essential	ADJ
bptjm-71	69	19	components	component	NOUN
bptjm-71	69	20	of	of	ADP
bptjm-71	69	21	the	the	DET
bptjm-71	69	22	senescence	senescence	NOUN
bptjm-71	69	23	program	program	NOUN
bptjm-71	69	24	.	.	PUNCT
bptjm-71	70	1	exposure	exposure	NOUN
bptjm-71	70	2	to	to	ADP
bptjm-71	70	3	tau	tau	PROPN
bptjm-71	70	4	has	have	AUX
bptjm-71	70	5	been	be	AUX
bptjm-71	70	6	shown	show	VERB
bptjm-71	70	7	to	to	PART
bptjm-71	70	8	increase	increase	VERB
bptjm-71	70	9	the	the	DET
bptjm-71	70	10	expression	expression	NOUN
bptjm-71	70	11	of	of	ADP
bptjm-71	70	12	senescence	senescence	NOUN
bptjm-71	70	13	-	-	PUNCT
bptjm-71	70	14	associated	associate	VERB
bptjm-71	70	15	markers	marker	NOUN
bptjm-71	70	16	,	,	PUNCT
bptjm-71	70	17	including	include	VERB
bptjm-71	70	18	p16ink4a	p16ink4a	NOUN
bptjm-71	70	19	and	and	CCONJ
bptjm-71	70	20	p21waf1	p21waf1	NOUN
bptjm-71	70	21	,	,	PUNCT
bptjm-71	70	22	in	in	ADP
bptjm-71	70	23	microglia	microglia	NOUN
bptjm-71	70	24	,	,	PUNCT
bptjm-71	70	25	potentially	potentially	ADV
bptjm-71	70	26	contributing	contribute	VERB
bptjm-71	70	27	to	to	PART
bptjm-71	70	28	neurodegeneration.24	neurodegeneration.24	VERB
bptjm-71	70	29	●	●	X
bptjm-71	70	30	cdkn2a	cdkn2a	X
bptjm-71	70	31	and	and	CCONJ
bptjm-71	70	32	cdkn2d	cdkn2d	PROPN
bptjm-71	70	33	/	/	SYM
bptjm-71	70	34	p19	p19	NOUN
bptjm-71	70	35	:	:	PUNCT
bptjm-71	70	36	neurons	neuron	NOUN
bptjm-71	70	37	expressing	express	VERB
bptjm-71	70	38	cdkn2d	cdkn2d	PROPN
bptjm-71	70	39	/	/	SYM
bptjm-71	70	40	p19	p19	NOUN
bptjm-71	70	41	,	,	PUNCT
bptjm-71	70	42	a	a	DET
bptjm-71	70	43	gene	gene	NOUN
bptjm-71	70	44	related	relate	VERB
bptjm-71	70	45	to	to	ADP
bptjm-71	70	46	cdkn2a	cdkn2a	PROPN
bptjm-71	70	47	,	,	PUNCT
bptjm-71	70	48	were	be	AUX
bptjm-71	70	49	found	find	VERB
bptjm-71	70	50	to	to	PART
bptjm-71	70	51	be	be	AUX
bptjm-71	70	52	more	more	ADV
bptjm-71	70	53	prone	prone	ADJ
bptjm-71	70	54	to	to	ADP
bptjm-71	70	55	containing	contain	VERB
bptjm-71	70	56	tau	tau	PROPN
bptjm-71	70	57	aggregates	aggregate	NOUN
bptjm-71	70	58	and	and	CCONJ
bptjm-71	70	59	displaying	display	VERB
bptjm-71	70	60	signs	sign	NOUN
bptjm-71	70	61	of	of	ADP
bptjm-71	70	62	neurodegeneration	neurodegeneration	NOUN
bptjm-71	70	63	,	,	PUNCT
bptjm-71	70	64	suggesting	suggest	VERB
bptjm-71	70	65	a	a	DET
bptjm-71	70	66	potential	potential	ADJ
bptjm-71	70	67	role	role	NOUN
bptjm-71	70	68	for	for	ADP
bptjm-71	70	69	senescent	senescent	ADJ
bptjm-71	70	70	neurons	neuron	NOUN
bptjm-71	70	71	in	in	ADP
bptjm-71	70	72	the	the	DET
bptjm-71	70	73	development	development	NOUN
bptjm-71	70	74	of	of	ADP
bptjm-71	70	75	tauopathy.25	tauopathy.25	NOUN
bptjm-71	70	76	additionally	additionally	ADV
bptjm-71	70	77	,	,	PUNCT
bptjm-71	70	78	nfts	nft	NOUN
bptjm-71	70	79	(	(	PUNCT
bptjm-71	70	80	neurofibrillary	neurofibrillary	ADJ
bptjm-71	70	81	tangles	tangle	NOUN
bptjm-71	70	82	)	)	PUNCT
bptjm-71	70	83	have	have	AUX
bptjm-71	70	84	been	be	AUX
bptjm-71	70	85	directly	directly	ADV
bptjm-71	70	86	linked	link	VERB
bptjm-71	70	87	to	to	ADP
bptjm-71	70	88	cdkn2a	cdkn2a	VERB
bptjm-71	70	89	upregulation.21	upregulation.21	ADJ
bptjm-71	70	90	other	other	ADJ
bptjm-71	70	91	biomarkers	biomarker	NOUN
bptjm-71	70	92	other	other	ADJ
bptjm-71	70	93	biomarkers	biomarker	NOUN
bptjm-71	70	94	associated	associate	VERB
bptjm-71	70	95	with	with	ADP
bptjm-71	70	96	senescent	senescent	ADJ
bptjm-71	70	97	cells	cell	NOUN
bptjm-71	70	98	and	and	CCONJ
bptjm-71	70	99	neurodegeneration	neurodegeneration	NOUN
bptjm-71	70	100	have	have	AUX
bptjm-71	70	101	been	be	AUX
bptjm-71	70	102	identified	identify	VERB
bptjm-71	70	103	.	.	PUNCT
bptjm-71	71	1	berkeley	berkeley	PROPN
bptjm-71	71	2	pharma	pharma	PROPN
bptjm-71	71	3	tech	tech	PROPN
bptjm-71	71	4	journal	journal	NOUN
bptjm-71	71	5	of	of	ADP
bptjm-71	71	6	medicine	medicine	NOUN
bptjm-71	71	7	|	|	ADV
bptjm-71	71	8	50	50	NUM
bptjm-71	71	9	●	●	NUM
bptjm-71	71	10	b2	b2	NOUN
bptjm-71	71	11	m	m	NOUN
bptjm-71	71	12	:	:	PUNCT
bptjm-71	71	13	b2	b2	NOUN
bptjm-71	71	14	m	m	NOUN
bptjm-71	71	15	is	be	AUX
bptjm-71	71	16	an	an	DET
bptjm-71	71	17	extracellular	extracellular	ADJ
bptjm-71	71	18	epitope	epitope	NOUN
bptjm-71	71	19	of	of	ADP
bptjm-71	71	20	senescent	senescent	ADJ
bptjm-71	71	21	cells	cell	NOUN
bptjm-71	71	22	and	and	CCONJ
bptjm-71	71	23	serves	serve	VERB
bptjm-71	71	24	as	as	ADP
bptjm-71	71	25	a	a	DET
bptjm-71	71	26	membrane	membrane	NOUN
bptjm-71	71	27	marker	marker	NOUN
bptjm-71	71	28	for	for	ADP
bptjm-71	71	29	mhc	mhc	PROPN
bptjm-71	71	30	class	class	PROPN
bptjm-71	71	31	i	i	PROPN
bptjm-71	71	32	molecules	molecule	NOUN
bptjm-71	71	33	.	.	PUNCT
bptjm-71	72	1	its	its	PRON
bptjm-71	72	2	expression	expression	NOUN
bptjm-71	72	3	may	may	AUX
bptjm-71	72	4	contribute	contribute	VERB
bptjm-71	72	5	to	to	ADP
bptjm-71	72	6	immune	immune	ADJ
bptjm-71	72	7	responses	response	NOUN
bptjm-71	72	8	and	and	CCONJ
bptjm-71	72	9	inflammation	inflammation	NOUN
bptjm-71	72	10	in	in	ADP
bptjm-71	72	11	the	the	DET
bptjm-71	72	12	context	context	NOUN
bptjm-71	72	13	of	of	ADP
bptjm-71	72	14	senescence.26	senescence.26	ADJ
bptjm-71	72	15	●	●	NOUN
bptjm-71	72	16	pai-1	pai-1	NUM
bptjm-71	72	17	:	:	PUNCT
bptjm-71	72	18	plasminogen	plasminogen	NOUN
bptjm-71	72	19	activator	activator	NOUN
bptjm-71	72	20	inhibitor-1	inhibitor-1	NUM
bptjm-71	72	21	is	be	AUX
bptjm-71	72	22	a	a	DET
bptjm-71	72	23	serine	serine	ADJ
bptjm-71	72	24	protease	protease	NOUN
bptjm-71	72	25	inhibitor	inhibitor	NOUN
bptjm-71	72	26	that	that	PRON
bptjm-71	72	27	increases	increase	VERB
bptjm-71	72	28	with	with	ADP
bptjm-71	72	29	aging	aging	NOUN
bptjm-71	72	30	and	and	CCONJ
bptjm-71	72	31	has	have	AUX
bptjm-71	72	32	been	be	AUX
bptjm-71	72	33	found	find	VERB
bptjm-71	72	34	to	to	PART
bptjm-71	72	35	contribute	contribute	VERB
bptjm-71	72	36	to	to	ADP
bptjm-71	72	37	brain	brain	NOUN
bptjm-71	72	38	cell	cell	NOUN
bptjm-71	72	39	senescence	senescence	NOUN
bptjm-71	72	40	.	.	PUNCT
bptjm-71	73	1	however	however	ADV
bptjm-71	73	2	,	,	PUNCT
bptjm-71	73	3	the	the	DET
bptjm-71	73	4	specific	specific	ADJ
bptjm-71	73	5	mechanisms	mechanism	NOUN
bptjm-71	73	6	linking	link	VERB
bptjm-71	73	7	pai-1	pai-1	PUNCT
bptjm-71	73	8	to	to	ADP
bptjm-71	73	9	neurodegeneration	neurodegeneration	NOUN
bptjm-71	73	10	are	be	AUX
bptjm-71	73	11	still	still	ADV
bptjm-71	73	12	being	be	AUX
bptjm-71	73	13	investigated.11	investigated.11	PROPN
bptjm-71	73	14	●	●	NUM
bptjm-71	73	15	hmgb1	hmgb1	NOUN
bptjm-71	73	16	:	:	PUNCT
bptjm-71	73	17	high	high	ADJ
bptjm-71	73	18	mobility	mobility	NOUN
bptjm-71	73	19	group	group	PROPN
bptjm-71	73	20	box	box	PROPN
bptjm-71	73	21	1	1	NUM
bptjm-71	73	22	serves	serve	VERB
bptjm-71	73	23	as	as	ADP
bptjm-71	73	24	a	a	DET
bptjm-71	73	25	crucial	crucial	ADJ
bptjm-71	73	26	biomarker	biomarker	NOUN
bptjm-71	73	27	.	.	PUNCT
bptjm-71	74	1	this	this	DET
bptjm-71	74	2	multifunctional	multifunctional	ADJ
bptjm-71	74	3	protein	protein	NOUN
bptjm-71	74	4	plays	play	VERB
bptjm-71	74	5	significant	significant	ADJ
bptjm-71	74	6	roles	role	NOUN
bptjm-71	74	7	within	within	ADP
bptjm-71	74	8	the	the	DET
bptjm-71	74	9	cell	cell	NOUN
bptjm-71	74	10	,	,	PUNCT
bptjm-71	74	11	particularly	particularly	ADV
bptjm-71	74	12	in	in	ADP
bptjm-71	74	13	dna	dna	PROPN
bptjm-71	74	14	repair	repair	NOUN
bptjm-71	74	15	and	and	CCONJ
bptjm-71	74	16	autophagy	autophagy	ADJ
bptjm-71	74	17	regulation	regulation	NOUN
bptjm-71	74	18	.	.	PUNCT
bptjm-71	75	1	studies	study	NOUN
bptjm-71	75	2	conducted	conduct	VERB
bptjm-71	75	3	by	by	ADP
bptjm-71	75	4	gaikwad	gaikwad	PROPN
bptjm-71	75	5	et	et	PROPN
bptjm-71	75	6	al	al	PROPN
bptjm-71	75	7	.	.	PROPN
bptjm-71	75	8	and	and	CCONJ
bptjm-71	75	9	rouilliard	rouilliard	PROPN
bptjm-71	75	10	et	et	PROPN
bptjm-71	75	11	al	al	PROPN
bptjm-71	75	12	.	.	PROPN
bptjm-71	75	13	have	have	AUX
bptjm-71	75	14	brought	bring	VERB
bptjm-71	75	15	to	to	PART
bptjm-71	75	16	light	light	VERB
bptjm-71	75	17	its	its	PRON
bptjm-71	75	18	potential	potential	ADJ
bptjm-71	75	19	implications	implication	NOUN
bptjm-71	75	20	in	in	ADP
bptjm-71	75	21	the	the	DET
bptjm-71	75	22	advancement	advancement	NOUN
bptjm-71	75	23	of	of	ADP
bptjm-71	75	24	neurodegenerative	neurodegenerative	ADJ
bptjm-71	75	25	diseases	disease	NOUN
bptjm-71	75	26	.	.	PUNCT
bptjm-71	76	1	hmgb1	hmgb1	PROPN
bptjm-71	76	2	's	's	PART
bptjm-71	76	3	involvement	involvement	NOUN
bptjm-71	76	4	as	as	ADP
bptjm-71	76	5	part	part	NOUN
bptjm-71	76	6	of	of	ADP
bptjm-71	76	7	the	the	DET
bptjm-71	76	8	sasp	sasp	NOUN
bptjm-71	76	9	is	be	AUX
bptjm-71	76	10	particularly	particularly	ADV
bptjm-71	76	11	noteworthy	noteworthy	ADJ
bptjm-71	76	12	,	,	PUNCT
bptjm-71	76	13	as	as	SCONJ
bptjm-71	76	14	it	it	PRON
bptjm-71	76	15	contributes	contribute	VERB
bptjm-71	76	16	to	to	ADP
bptjm-71	76	17	neuroinflammation	neuroinflammation	NOUN
bptjm-71	76	18	and	and	CCONJ
bptjm-71	76	19	impedes	impede	VERB
bptjm-71	76	20	the	the	DET
bptjm-71	76	21	growth	growth	NOUN
bptjm-71	76	22	of	of	ADP
bptjm-71	76	23	myelin	myelin	NOUN
bptjm-71	76	24	,	,	PUNCT
bptjm-71	76	25	which	which	PRON
bptjm-71	76	26	is	be	AUX
bptjm-71	76	27	essential	essential	ADJ
bptjm-71	76	28	for	for	ADP
bptjm-71	76	29	nerve	nerve	NOUN
bptjm-71	76	30	fiber	fiber	NOUN
bptjm-71	76	31	insulation	insulation	NOUN
bptjm-71	76	32	.	.	PUNCT
bptjm-71	77	1	15,27	15,27	NUM
bptjm-71	77	2	●	●	NUM
bptjm-71	77	3	lamin	lamin	NOUN
bptjm-71	77	4	b1	b1	NOUN
bptjm-71	77	5	:	:	PUNCT
bptjm-71	77	6	lamin	lamin	NOUN
bptjm-71	77	7	b1	b1	NOUN
bptjm-71	77	8	is	be	AUX
bptjm-71	77	9	a	a	DET
bptjm-71	77	10	protein	protein	NOUN
bptjm-71	77	11	that	that	PRON
bptjm-71	77	12	plays	play	VERB
bptjm-71	77	13	a	a	DET
bptjm-71	77	14	crucial	crucial	ADJ
bptjm-71	77	15	role	role	NOUN
bptjm-71	77	16	in	in	ADP
bptjm-71	77	17	maintaining	maintain	VERB
bptjm-71	77	18	the	the	DET
bptjm-71	77	19	structural	structural	ADJ
bptjm-71	77	20	integrity	integrity	NOUN
bptjm-71	77	21	of	of	ADP
bptjm-71	77	22	the	the	DET
bptjm-71	77	23	cell	cell	NOUN
bptjm-71	77	24	nucleus	nucleus	NOUN
bptjm-71	77	25	.	.	PUNCT
bptjm-71	78	1	it	it	PRON
bptjm-71	78	2	is	be	AUX
bptjm-71	78	3	a	a	DET
bptjm-71	78	4	component	component	NOUN
bptjm-71	78	5	of	of	ADP
bptjm-71	78	6	the	the	DET
bptjm-71	78	7	nuclear	nuclear	ADJ
bptjm-71	78	8	lamina	lamina	PROPN
bptjm-71	78	9	,	,	PUNCT
bptjm-71	78	10	a	a	DET
bptjm-71	78	11	network	network	NOUN
bptjm-71	78	12	of	of	ADP
bptjm-71	78	13	proteins	protein	NOUN
bptjm-71	78	14	that	that	PRON
bptjm-71	78	15	provides	provide	VERB
bptjm-71	78	16	support	support	NOUN
bptjm-71	78	17	to	to	ADP
bptjm-71	78	18	the	the	DET
bptjm-71	78	19	nuclear	nuclear	ADJ
bptjm-71	78	20	envelope	envelope	NOUN
bptjm-71	78	21	.	.	PUNCT
bptjm-71	79	1	lamin	lamin	NOUN
bptjm-71	79	2	b1	b1	NOUN
bptjm-71	79	3	has	have	AUX
bptjm-71	79	4	been	be	AUX
bptjm-71	79	5	implicated	implicate	VERB
bptjm-71	79	6	in	in	ADP
bptjm-71	79	7	the	the	DET
bptjm-71	79	8	aging	age	VERB
bptjm-71	79	9	process	process	NOUN
bptjm-71	79	10	as	as	SCONJ
bptjm-71	79	11	its	its	PRON
bptjm-71	79	12	expression	expression	NOUN
bptjm-71	79	13	levels	level	NOUN
bptjm-71	79	14	decline	decline	VERB
bptjm-71	79	15	with	with	ADP
bptjm-71	79	16	age	age	NOUN
bptjm-71	79	17	in	in	ADP
bptjm-71	79	18	various	various	ADJ
bptjm-71	79	19	tissues.28	tissues.28	NOUN
bptjm-71	79	20	reduced	reduce	VERB
bptjm-71	79	21	levels	level	NOUN
bptjm-71	79	22	of	of	ADP
bptjm-71	79	23	lamin	lamin	NOUN
bptjm-71	79	24	b1	b1	NOUN
bptjm-71	79	25	have	have	AUX
bptjm-71	79	26	been	be	AUX
bptjm-71	79	27	observed	observe	VERB
bptjm-71	79	28	in	in	ADP
bptjm-71	79	29	certain	certain	ADJ
bptjm-71	79	30	senescent	senescent	ADJ
bptjm-71	79	31	cells	cell	NOUN
bptjm-71	79	32	,	,	PUNCT
bptjm-71	79	33	and	and	CCONJ
bptjm-71	79	34	its	its	PRON
bptjm-71	79	35	loss	loss	NOUN
bptjm-71	79	36	has	have	AUX
bptjm-71	79	37	been	be	AUX
bptjm-71	79	38	linked	link	VERB
bptjm-71	79	39	to	to	ADP
bptjm-71	79	40	nuclear	nuclear	ADJ
bptjm-71	79	41	envelope	envelope	NOUN
bptjm-71	79	42	disorganization	disorganization	NOUN
bptjm-71	79	43	and	and	CCONJ
bptjm-71	79	44	altered	altered	ADJ
bptjm-71	79	45	gene	gene	NOUN
bptjm-71	79	46	expression	expression	NOUN
bptjm-71	79	47	,	,	PUNCT
bptjm-71	79	48	contributing	contribute	VERB
bptjm-71	79	49	to	to	ADP
bptjm-71	79	50	cellular	cellular	ADJ
bptjm-71	79	51	dysfunction	dysfunction	NOUN
bptjm-71	79	52	and	and	CCONJ
bptjm-71	79	53	aging	age	VERB
bptjm-71	79	54	-	-	PUNCT
bptjm-71	79	55	related	relate	VERB
bptjm-71	79	56	changes.28	changes.28	NOUN
bptjm-71	79	57	●	●	NUM
bptjm-71	79	58	igfbp5	igfbp5	NOUN
bptjm-71	79	59	:	:	PUNCT
bptjm-71	79	60	insulin	insulin	NOUN
bptjm-71	79	61	-	-	PUNCT
bptjm-71	79	62	like	like	ADJ
bptjm-71	79	63	growth	growth	NOUN
bptjm-71	79	64	factor	factor	NOUN
bptjm-71	79	65	binding	bind	VERB
bptjm-71	79	66	protein	protein	NOUN
bptjm-71	79	67	5	5	NUM
bptjm-71	79	68	is	be	AUX
bptjm-71	79	69	a	a	DET
bptjm-71	79	70	member	member	NOUN
bptjm-71	79	71	of	of	ADP
bptjm-71	79	72	the	the	DET
bptjm-71	79	73	insulin	insulin	NOUN
bptjm-71	79	74	-	-	PUNCT
bptjm-71	79	75	like	like	ADJ
bptjm-71	79	76	growth	growth	NOUN
bptjm-71	79	77	factor	factor	NOUN
bptjm-71	79	78	-	-	PUNCT
bptjm-71	79	79	binding	bind	VERB
bptjm-71	79	80	protein	protein	NOUN
bptjm-71	79	81	family	family	NOUN
bptjm-71	79	82	and	and	CCONJ
bptjm-71	79	83	plays	play	VERB
bptjm-71	79	84	a	a	DET
bptjm-71	79	85	role	role	NOUN
bptjm-71	79	86	in	in	ADP
bptjm-71	79	87	regulating	regulate	VERB
bptjm-71	79	88	the	the	DET
bptjm-71	79	89	bioavailability	bioavailability	NOUN
bptjm-71	79	90	and	and	CCONJ
bptjm-71	79	91	activity	activity	NOUN
bptjm-71	79	92	of	of	ADP
bptjm-71	79	93	insulin	insulin	NOUN
bptjm-71	79	94	-	-	PUNCT
bptjm-71	79	95	like	like	ADJ
bptjm-71	79	96	growth	growth	NOUN
bptjm-71	79	97	factors	factor	NOUN
bptjm-71	79	98	(	(	PUNCT
bptjm-71	79	99	igfs	igfs	NOUN
bptjm-71	79	100	)	)	PUNCT
bptjm-71	79	101	.	.	PUNCT
bptjm-71	80	1	igfs	igfs	PROPN
bptjm-71	80	2	are	be	AUX
bptjm-71	80	3	essential	essential	ADJ
bptjm-71	80	4	for	for	ADP
bptjm-71	80	5	cell	cell	NOUN
bptjm-71	80	6	growth	growth	NOUN
bptjm-71	80	7	,	,	PUNCT
bptjm-71	80	8	proliferation	proliferation	NOUN
bptjm-71	80	9	,	,	PUNCT
bptjm-71	80	10	and	and	CCONJ
bptjm-71	80	11	survival	survival	NOUN
bptjm-71	80	12	.	.	PUNCT
bptjm-71	81	1	igfbp5	igfbp5	NOUN
bptjm-71	81	2	modulates	modulate	VERB
bptjm-71	81	3	the	the	DET
bptjm-71	81	4	actions	action	NOUN
bptjm-71	81	5	of	of	ADP
bptjm-71	81	6	igfs	igfs	NOUN
bptjm-71	81	7	by	by	ADP
bptjm-71	81	8	binding	bind	VERB
bptjm-71	81	9	to	to	ADP
bptjm-71	81	10	them	they	PRON
bptjm-71	81	11	and	and	CCONJ
bptjm-71	81	12	regulating	regulate	VERB
bptjm-71	81	13	their	their	PRON
bptjm-71	81	14	interactions	interaction	NOUN
bptjm-71	81	15	with	with	ADP
bptjm-71	81	16	cell	cell	NOUN
bptjm-71	81	17	surface	surface	NOUN
bptjm-71	81	18	receptors.29	receptors.29	NOUN
bptjm-71	81	19	additionally	additionally	ADV
bptjm-71	81	20	,	,	PUNCT
bptjm-71	81	21	igfbp5	igfbp5	NOUN
bptjm-71	81	22	has	have	AUX
bptjm-71	81	23	been	be	AUX
bptjm-71	81	24	found	find	VERB
bptjm-71	81	25	to	to	PART
bptjm-71	81	26	be	be	AUX
bptjm-71	81	27	involved	involve	VERB
bptjm-71	81	28	in	in	ADP
bptjm-71	81	29	processes	process	NOUN
bptjm-71	81	30	related	relate	VERB
bptjm-71	81	31	to	to	ADP
bptjm-71	81	32	brain	brain	NOUN
bptjm-71	81	33	development	development	NOUN
bptjm-71	81	34	and	and	CCONJ
bptjm-71	81	35	function	function	NOUN
bptjm-71	81	36	,	,	PUNCT
bptjm-71	81	37	and	and	CCONJ
bptjm-71	81	38	its	its	PRON
bptjm-71	81	39	dysregulation	dysregulation	NOUN
bptjm-71	81	40	may	may	AUX
bptjm-71	81	41	influence	influence	VERB
bptjm-71	81	42	neuronal	neuronal	ADJ
bptjm-71	81	43	survival	survival	NOUN
bptjm-71	81	44	and	and	CCONJ
bptjm-71	81	45	synaptic	synaptic	ADJ
bptjm-71	81	46	plasticity	plasticity	NOUN
bptjm-71	81	47	,	,	PUNCT
bptjm-71	81	48	potentially	potentially	ADV
bptjm-71	81	49	contributing	contribute	VERB
bptjm-71	81	50	to	to	ADP
bptjm-71	81	51	neurodegeneration.29	neurodegeneration.29	PROPN
bptjm-71	81	52	berkeley	berkeley	PROPN
bptjm-71	81	53	pharma	pharma	PROPN
bptjm-71	81	54	tech	tech	NOUN
bptjm-71	81	55	journal	journal	NOUN
bptjm-71	81	56	of	of	ADP
bptjm-71	81	57	medicine	medicine	NOUN
bptjm-71	82	1	|	|	ADV
bptjm-71	82	2	51	51	NUM
bptjm-71	82	3	2.3	2.3	NUM
bptjm-71	82	4	.	.	PUNCT
bptjm-71	83	1	tau	tau	PROPN
bptjm-71	83	2	pathology	pathology	NOUN
bptjm-71	83	3	the	the	DET
bptjm-71	83	4	tau	tau	PROPN
bptjm-71	83	5	protein	protein	NOUN
bptjm-71	83	6	,	,	PUNCT
bptjm-71	83	7	predominantly	predominantly	ADV
bptjm-71	83	8	located	locate	VERB
bptjm-71	83	9	within	within	ADP
bptjm-71	83	10	neurons	neuron	NOUN
bptjm-71	83	11	,	,	PUNCT
bptjm-71	83	12	plays	play	VERB
bptjm-71	83	13	a	a	DET
bptjm-71	83	14	vital	vital	ADJ
bptjm-71	83	15	role	role	NOUN
bptjm-71	83	16	in	in	ADP
bptjm-71	83	17	maintaining	maintain	VERB
bptjm-71	83	18	the	the	DET
bptjm-71	83	19	structural	structural	ADJ
bptjm-71	83	20	integrity	integrity	NOUN
bptjm-71	83	21	of	of	ADP
bptjm-71	83	22	nerve	nerve	NOUN
bptjm-71	83	23	cells	cell	NOUN
bptjm-71	83	24	by	by	ADP
bptjm-71	83	25	stabilizing	stabilize	VERB
bptjm-71	83	26	microtubules	microtubule	NOUN
bptjm-71	83	27	and	and	CCONJ
bptjm-71	83	28	facilitating	facilitate	VERB
bptjm-71	83	29	efficient	efficient	ADJ
bptjm-71	83	30	axonal	axonal	ADJ
bptjm-71	83	31	transport.4	transport.4	NOUN
bptjm-71	83	32	in	in	ADP
bptjm-71	83	33	addition	addition	NOUN
bptjm-71	83	34	to	to	ADP
bptjm-71	83	35	its	its	PRON
bptjm-71	83	36	structural	structural	ADJ
bptjm-71	83	37	functions	function	NOUN
bptjm-71	83	38	,	,	PUNCT
bptjm-71	83	39	tau	tau	PROPN
bptjm-71	83	40	protein	protein	NOUN
bptjm-71	83	41	is	be	AUX
bptjm-71	83	42	involved	involve	VERB
bptjm-71	83	43	in	in	ADP
bptjm-71	83	44	essential	essential	ADJ
bptjm-71	83	45	cellular	cellular	ADJ
bptjm-71	83	46	processes	process	NOUN
bptjm-71	83	47	such	such	ADJ
bptjm-71	83	48	as	as	ADP
bptjm-71	83	49	cell	cell	NOUN
bptjm-71	83	50	signaling	signal	VERB
bptjm-71	83	51	,	,	PUNCT
bptjm-71	83	52	synaptic	synaptic	ADJ
bptjm-71	83	53	plasticity	plasticity	NOUN
bptjm-71	83	54	,	,	PUNCT
bptjm-71	83	55	and	and	CCONJ
bptjm-71	83	56	the	the	DET
bptjm-71	83	57	preservation	preservation	NOUN
bptjm-71	83	58	of	of	ADP
bptjm-71	83	59	genomic	genomic	ADJ
bptjm-71	83	60	stability	stability	NOUN
bptjm-71	83	61	,	,	PUNCT
bptjm-71	83	62	and	and	CCONJ
bptjm-71	83	63	in	in	ADP
bptjm-71	83	64	olgs	olgs	NOUN
bptjm-71	83	65	cells	cell	NOUN
bptjm-71	83	66	,	,	PUNCT
bptjm-71	83	67	it	it	PRON
bptjm-71	83	68	also	also	ADV
bptjm-71	83	69	plays	play	VERB
bptjm-71	83	70	the	the	DET
bptjm-71	83	71	role	role	NOUN
bptjm-71	83	72	of	of	ADP
bptjm-71	83	73	myelination.30,31	myelination.30,31	NOUN
bptjm-71	83	74	when	when	SCONJ
bptjm-71	83	75	tau	tau	PROPN
bptjm-71	83	76	becomes	become	VERB
bptjm-71	83	77	abnormal	abnormal	ADJ
bptjm-71	83	78	,	,	PUNCT
bptjm-71	83	79	it	it	PRON
bptjm-71	83	80	can	can	AUX
bptjm-71	83	81	contribute	contribute	VERB
bptjm-71	83	82	to	to	ADP
bptjm-71	83	83	the	the	DET
bptjm-71	83	84	development	development	NOUN
bptjm-71	83	85	of	of	ADP
bptjm-71	83	86	neurodegenerative	neurodegenerative	ADJ
bptjm-71	83	87	diseases	disease	NOUN
bptjm-71	83	88	.	.	PUNCT
bptjm-71	84	1	excessive	excessive	ADJ
bptjm-71	84	2	phosphorylation	phosphorylation	NOUN
bptjm-71	84	3	,	,	PUNCT
bptjm-71	84	4	genetic	genetic	ADJ
bptjm-71	84	5	mutations	mutation	NOUN
bptjm-71	84	6	,	,	PUNCT
bptjm-71	84	7	and	and	CCONJ
bptjm-71	84	8	mis	mis	PROPN
bptjm-71	84	9	-	-	PUNCT
bptjm-71	84	10	splicing	splicing	NOUN
bptjm-71	84	11	contribute	contribute	NOUN
bptjm-71	84	12	to	to	ADP
bptjm-71	84	13	the	the	DET
bptjm-71	84	14	abnormal	abnormal	ADJ
bptjm-71	84	15	aggregation	aggregation	NOUN
bptjm-71	84	16	of	of	ADP
bptjm-71	84	17	tau	tau	PROPN
bptjm-71	84	18	protein	protein	NOUN
bptjm-71	84	19	,	,	PUNCT
bptjm-71	84	20	resulting	result	VERB
bptjm-71	84	21	in	in	ADP
bptjm-71	84	22	the	the	DET
bptjm-71	84	23	formation	formation	NOUN
bptjm-71	84	24	of	of	ADP
bptjm-71	84	25	either	either	PRON
bptjm-71	84	26	tau	tau	PROPN
bptjm-71	84	27	oligomers	oligomer	NOUN
bptjm-71	84	28	or	or	CCONJ
bptjm-71	84	29	neurofibrillary	neurofibrillary	ADJ
bptjm-71	84	30	tangles	tangle	NOUN
bptjm-71	84	31	(	(	PUNCT
bptjm-71	84	32	nfts).32	nfts).32	X
bptjm-71	84	33	tau	tau	PROPN
bptjm-71	84	34	oligomers	oligomer	NOUN
bptjm-71	84	35	are	be	AUX
bptjm-71	84	36	small	small	ADJ
bptjm-71	84	37	aggregates	aggregate	NOUN
bptjm-71	84	38	of	of	ADP
bptjm-71	84	39	abnormal	abnormal	ADJ
bptjm-71	84	40	tau	tau	PROPN
bptjm-71	84	41	protein	protein	NOUN
bptjm-71	84	42	that	that	PRON
bptjm-71	84	43	form	form	VERB
bptjm-71	84	44	prior	prior	ADV
bptjm-71	84	45	to	to	ADP
bptjm-71	84	46	the	the	DET
bptjm-71	84	47	development	development	NOUN
bptjm-71	84	48	of	of	ADP
bptjm-71	84	49	nfts	nft	NOUN
bptjm-71	84	50	,	,	PUNCT
bptjm-71	84	51	which	which	PRON
bptjm-71	84	52	are	be	AUX
bptjm-71	84	53	larger	large	ADJ
bptjm-71	84	54	insoluble	insoluble	ADJ
bptjm-71	84	55	clumps	clump	NOUN
bptjm-71	84	56	of	of	ADP
bptjm-71	84	57	hyperphosphorylated	hyperphosphorylated	ADJ
bptjm-71	84	58	tau	tau	PROPN
bptjm-71	84	59	protein	protein	NOUN
bptjm-71	84	60	.	.	PUNCT
bptjm-71	85	1	both	both	PRON
bptjm-71	85	2	tau	tau	PROPN
bptjm-71	85	3	oligomers	oligomer	NOUN
bptjm-71	85	4	and	and	CCONJ
bptjm-71	85	5	nfts	nft	NOUN
bptjm-71	85	6	contribute	contribute	VERB
bptjm-71	85	7	to	to	ADP
bptjm-71	85	8	pathogenesis	pathogenesis	NOUN
bptjm-71	85	9	of	of	ADP
bptjm-71	85	10	neurodegenerative	neurodegenerative	ADJ
bptjm-71	85	11	diseases	disease	NOUN
bptjm-71	85	12	.	.	PUNCT
bptjm-71	86	1	abnormal	abnormal	ADJ
bptjm-71	86	2	tau	tau	PROPN
bptjm-71	86	3	can	can	AUX
bptjm-71	86	4	be	be	AUX
bptjm-71	86	5	secreted	secrete	VERB
bptjm-71	86	6	by	by	ADP
bptjm-71	86	7	neurons	neuron	NOUN
bptjm-71	86	8	into	into	ADP
bptjm-71	86	9	extracellular	extracellular	ADJ
bptjm-71	86	10	space	space	NOUN
bptjm-71	86	11	,	,	PUNCT
bptjm-71	86	12	which	which	PRON
bptjm-71	86	13	are	be	AUX
bptjm-71	86	14	taken	take	VERB
bptjm-71	86	15	up	up	ADP
bptjm-71	86	16	by	by	ADP
bptjm-71	86	17	healthy	healthy	ADJ
bptjm-71	86	18	neighboring	neighboring	NOUN
bptjm-71	86	19	neuronal	neuronal	ADJ
bptjm-71	86	20	and	and	CCONJ
bptjm-71	86	21	glial	glial	ADJ
bptjm-71	86	22	cells	cell	NOUN
bptjm-71	86	23	through	through	ADP
bptjm-71	86	24	endocytosis	endocytosis	NOUN
bptjm-71	86	25	,	,	PUNCT
bptjm-71	86	26	pinocytosis	pinocytosis	NOUN
bptjm-71	86	27	,	,	PUNCT
bptjm-71	86	28	or	or	CCONJ
bptjm-71	86	29	phagocytosis	phagocytosis	NOUN
bptjm-71	86	30	means	mean	NOUN
bptjm-71	86	31	,	,	PUNCT
bptjm-71	86	32	thereby	thereby	ADV
bptjm-71	86	33	contributing	contribute	VERB
bptjm-71	86	34	to	to	ADP
bptjm-71	86	35	the	the	DET
bptjm-71	86	36	propagation	propagation	NOUN
bptjm-71	86	37	of	of	ADP
bptjm-71	86	38	tau	tau	PROPN
bptjm-71	86	39	pathology	pathology	NOUN
bptjm-71	86	40	across	across	ADP
bptjm-71	86	41	interconnected	interconnected	ADJ
bptjm-71	86	42	brain	brain	NOUN
bptjm-71	86	43	regions.27	regions.27	NOUN
bptjm-71	86	44	in	in	ADP
bptjm-71	86	45	addition	addition	NOUN
bptjm-71	86	46	,	,	PUNCT
bptjm-71	86	47	extracellular	extracellular	ADJ
bptjm-71	86	48	tau	tau	PROPN
bptjm-71	86	49	was	be	AUX
bptjm-71	86	50	found	find	VERB
bptjm-71	86	51	to	to	PART
bptjm-71	86	52	induce	induce	VERB
bptjm-71	86	53	human	human	ADJ
bptjm-71	86	54	astrocyte	astrocyte	NOUN
bptjm-71	86	55	senescence	senescence	NOUN
bptjm-71	86	56	,	,	PUNCT
bptjm-71	86	57	inflammation	inflammation	NOUN
bptjm-71	86	58	,	,	PUNCT
bptjm-71	86	59	and	and	CCONJ
bptjm-71	86	60	sasps	sasps	NOUN
bptjm-71	86	61	.	.	PUNCT
bptjm-71	87	1	the	the	DET
bptjm-71	87	2	inflammatory	inflammatory	ADJ
bptjm-71	87	3	state	state	NOUN
bptjm-71	87	4	can	can	AUX
bptjm-71	87	5	cause	cause	VERB
bptjm-71	87	6	induction	induction	NOUN
bptjm-71	87	7	of	of	ADP
bptjm-71	87	8	senescence	senescence	NOUN
bptjm-71	87	9	in	in	ADP
bptjm-71	87	10	nearby	nearby	ADJ
bptjm-71	87	11	cells	cell	NOUN
bptjm-71	87	12	in	in	ADP
bptjm-71	87	13	a	a	DET
bptjm-71	87	14	paracrine	paracrine	NOUN
bptjm-71	87	15	-	-	PUNCT
bptjm-71	87	16	like	like	ADJ
bptjm-71	87	17	manner	manner	NOUN
bptjm-71	87	18	,	,	PUNCT
bptjm-71	87	19	further	far	ADV
bptjm-71	87	20	propagating	propagate	VERB
bptjm-71	87	21	neurodegeneration	neurodegeneration	NOUN
bptjm-71	87	22	,	,	PUNCT
bptjm-71	87	23	which	which	PRON
bptjm-71	87	24	is	be	AUX
bptjm-71	87	25	why	why	SCONJ
bptjm-71	87	26	overall	overall	ADJ
bptjm-71	87	27	extracellular	extracellular	ADJ
bptjm-71	87	28	tau	tau	PROPN
bptjm-71	87	29	may	may	AUX
bptjm-71	87	30	be	be	AUX
bptjm-71	87	31	more	more	ADV
bptjm-71	87	32	neurotoxic	neurotoxic	ADJ
bptjm-71	87	33	than	than	ADP
bptjm-71	87	34	intracellular	intracellular	ADJ
bptjm-71	87	35	tau.4	tau.4	NOUN
bptjm-71	87	36	one	one	NUM
bptjm-71	87	37	pathological	pathological	ADJ
bptjm-71	87	38	change	change	NOUN
bptjm-71	87	39	caused	cause	VERB
bptjm-71	87	40	by	by	ADP
bptjm-71	87	41	abnormal	abnormal	ADJ
bptjm-71	87	42	tau	tau	PROPN
bptjm-71	87	43	accumulation	accumulation	NOUN
bptjm-71	87	44	is	be	AUX
bptjm-71	87	45	the	the	DET
bptjm-71	87	46	disruption	disruption	NOUN
bptjm-71	87	47	of	of	ADP
bptjm-71	87	48	cell	cell	NOUN
bptjm-71	87	49	function	function	NOUN
bptjm-71	87	50	and	and	CCONJ
bptjm-71	87	51	the	the	DET
bptjm-71	87	52	blood	blood	NOUN
bptjm-71	87	53	brain	brain	NOUN
bptjm-71	87	54	barrier	barrier	NOUN
bptjm-71	87	55	(	(	PUNCT
bptjm-71	87	56	bbb	bbb	PROPN
bptjm-71	87	57	)	)	PUNCT
bptjm-71	87	58	,	,	PUNCT
bptjm-71	87	59	which	which	PRON
bptjm-71	87	60	is	be	AUX
bptjm-71	87	61	responsible	responsible	ADJ
bptjm-71	87	62	for	for	ADP
bptjm-71	87	63	protecting	protect	VERB
bptjm-71	87	64	the	the	DET
bptjm-71	87	65	cns	cns	NOUN
bptjm-71	87	66	from	from	ADP
bptjm-71	87	67	pathogens	pathogen	NOUN
bptjm-71	87	68	and	and	CCONJ
bptjm-71	87	69	maintaining	maintain	VERB
bptjm-71	87	70	homeostasis	homeostasis	NOUN
bptjm-71	87	71	in	in	ADP
bptjm-71	87	72	the	the	DET
bptjm-71	87	73	microenvironment	microenvironment	NOUN
bptjm-71	87	74	of	of	ADP
bptjm-71	87	75	the	the	DET
bptjm-71	87	76	brain.31	brain.31	NOUN
bptjm-71	87	77	other	other	ADJ
bptjm-71	87	78	tau	tau	PROPN
bptjm-71	87	79	pathologies	pathology	NOUN
bptjm-71	87	80	include	include	VERB
bptjm-71	87	81	chronic	chronic	ADJ
bptjm-71	87	82	neuroinflammation	neuroinflammation	NOUN
bptjm-71	87	83	,	,	PUNCT
bptjm-71	87	84	dna	dna	NOUN
bptjm-71	87	85	damage	damage	NOUN
bptjm-71	87	86	,	,	PUNCT
bptjm-71	87	87	and	and	CCONJ
bptjm-71	87	88	oxidative	oxidative	ADJ
bptjm-71	87	89	stress	stress	NOUN
bptjm-71	87	90	,	,	PUNCT
bptjm-71	87	91	which	which	PRON
bptjm-71	87	92	are	be	AUX
bptjm-71	87	93	known	know	VERB
bptjm-71	87	94	stressors	stressor	NOUN
bptjm-71	87	95	of	of	ADP
bptjm-71	87	96	senescence	senescence	NOUN
bptjm-71	87	97	.	.	PUNCT
bptjm-71	88	1	these	these	DET
bptjm-71	88	2	tau	tau	NOUN
bptjm-71	88	3	-	-	PUNCT
bptjm-71	88	4	related	relate	VERB
bptjm-71	88	5	pathologies	pathology	NOUN
bptjm-71	88	6	contribute	contribute	VERB
bptjm-71	88	7	to	to	ADP
bptjm-71	88	8	the	the	DET
bptjm-71	88	9	establishment	establishment	NOUN
bptjm-71	88	10	of	of	ADP
bptjm-71	88	11	a	a	DET
bptjm-71	88	12	vicious	vicious	ADJ
bptjm-71	88	13	cycle	cycle	NOUN
bptjm-71	88	14	,	,	PUNCT
bptjm-71	88	15	where	where	SCONJ
bptjm-71	88	16	tau	tau	PROPN
bptjm-71	88	17	pathology	pathology	NOUN
bptjm-71	88	18	triggers	trigger	VERB
bptjm-71	88	19	senescence	senescence	NOUN
bptjm-71	88	20	,	,	PUNCT
bptjm-71	88	21	leading	lead	VERB
bptjm-71	88	22	to	to	ADP
bptjm-71	88	23	the	the	DET
bptjm-71	88	24	release	release	NOUN
bptjm-71	88	25	of	of	ADP
bptjm-71	88	26	toxic	toxic	ADJ
bptjm-71	88	27	sasp	sasp	NOUN
bptjm-71	88	28	factors	factor	NOUN
bptjm-71	88	29	that	that	PRON
bptjm-71	88	30	,	,	PUNCT
bptjm-71	88	31	in	in	ADP
bptjm-71	88	32	turn	turn	NOUN
bptjm-71	88	33	,	,	PUNCT
bptjm-71	88	34	exacerbate	exacerbate	VERB
bptjm-71	88	35	the	the	DET
bptjm-71	88	36	formation	formation	NOUN
bptjm-71	88	37	of	of	ADP
bptjm-71	88	38	abnormal	abnormal	ADJ
bptjm-71	88	39	tau	tau	PROPN
bptjm-71	88	40	(	(	PUNCT
bptjm-71	88	41	fig	fig	NOUN
bptjm-71	88	42	.	.	PUNCT
bptjm-71	89	1	3	3	NUM
bptjm-71	89	2	)	)	PUNCT
bptjm-71	89	3	.	.	PUNCT
bptjm-71	90	1	berkeley	berkeley	PROPN
bptjm-71	90	2	pharma	pharma	PROPN
bptjm-71	90	3	tech	tech	PROPN
bptjm-71	90	4	journal	journal	NOUN
bptjm-71	90	5	of	of	ADP
bptjm-71	90	6	medicine	medicine	NOUN
bptjm-71	90	7	|	|	ADV
bptjm-71	90	8	52	52	NUM
bptjm-71	90	9	neurons	neuron	NOUN
bptjm-71	90	10	senescent	senescent	ADJ
bptjm-71	90	11	cells	cell	NOUN
bptjm-71	90	12	are	be	AUX
bptjm-71	90	13	present	present	ADJ
bptjm-71	90	14	in	in	ADP
bptjm-71	90	15	both	both	CCONJ
bptjm-71	90	16	ad	ad	NOUN
bptjm-71	90	17	and	and	CCONJ
bptjm-71	90	18	non	non	ADJ
bptjm-71	90	19	-	-	ADJ
bptjm-71	90	20	ad	ad	ADJ
bptjm-71	90	21	brains	brain	NOUN
bptjm-71	90	22	.	.	PUNCT
bptjm-71	91	1	however	however	ADV
bptjm-71	91	2	,	,	PUNCT
bptjm-71	91	3	it	it	PRON
bptjm-71	91	4	has	have	AUX
bptjm-71	91	5	been	be	AUX
bptjm-71	91	6	determined	determine	VERB
bptjm-71	91	7	that	that	SCONJ
bptjm-71	91	8	the	the	DET
bptjm-71	91	9	number	number	NOUN
bptjm-71	91	10	of	of	ADP
bptjm-71	91	11	senescent	senescent	ADJ
bptjm-71	91	12	cells	cell	NOUN
bptjm-71	91	13	was	be	AUX
bptjm-71	91	14	significantly	significantly	ADV
bptjm-71	91	15	higher	high	ADJ
bptjm-71	91	16	in	in	ADP
bptjm-71	91	17	ad	ad	NOUN
bptjm-71	91	18	brains	brain	NOUN
bptjm-71	91	19	.	.	PUNCT
bptjm-71	92	1	additionally	additionally	ADV
bptjm-71	92	2	,	,	PUNCT
bptjm-71	92	3	a	a	DET
bptjm-71	92	4	subset	subset	NOUN
bptjm-71	92	5	of	of	ADP
bptjm-71	92	6	senescent	senescent	ADJ
bptjm-71	92	7	cells	cell	NOUN
bptjm-71	92	8	in	in	ADP
bptjm-71	92	9	ad	ad	NOUN
bptjm-71	92	10	brains	brain	NOUN
bptjm-71	92	11	were	be	AUX
bptjm-71	92	12	neurons	neuron	NOUN
bptjm-71	92	13	that	that	PRON
bptjm-71	92	14	expressed	express	VERB
bptjm-71	92	15	the	the	DET
bptjm-71	92	16	gene	gene	NOUN
bptjm-71	92	17	cdkn2d	cdkn2d	PROPN
bptjm-71	92	18	/	/	SYM
bptjm-71	92	19	p19	p19	NOUN
bptjm-71	92	20	.	.	PUNCT
bptjm-71	93	1	these	these	DET
bptjm-71	93	2	neurons	neuron	NOUN
bptjm-71	93	3	also	also	ADV
bptjm-71	93	4	showed	show	VERB
bptjm-71	93	5	signs	sign	NOUN
bptjm-71	93	6	of	of	ADP
bptjm-71	93	7	tau	tau	PROPN
bptjm-71	93	8	neuropathology.25	neuropathology.25	PROPN
bptjm-71	93	9	moreover	moreover	ADV
bptjm-71	93	10	,	,	PUNCT
bptjm-71	93	11	an	an	DET
bptjm-71	93	12	examination	examination	NOUN
bptjm-71	93	13	of	of	ADP
bptjm-71	93	14	the	the	DET
bptjm-71	93	15	transcriptomic	transcriptomic	ADJ
bptjm-71	93	16	profile	profile	NOUN
bptjm-71	93	17	of	of	ADP
bptjm-71	93	18	cortical	cortical	ADJ
bptjm-71	93	19	neurons	neuron	NOUN
bptjm-71	93	20	containing	contain	VERB
bptjm-71	93	21	neurofibrillary	neurofibrillary	ADJ
bptjm-71	93	22	tangles	tangle	NOUN
bptjm-71	93	23	(	(	PUNCT
bptjm-71	93	24	nfts	nft	NOUN
bptjm-71	93	25	)	)	PUNCT
bptjm-71	93	26	in	in	ADP
bptjm-71	93	27	ad	ad	NOUN
bptjm-71	93	28	brains	brain	NOUN
bptjm-71	93	29	revealed	reveal	VERB
bptjm-71	93	30	that	that	SCONJ
bptjm-71	93	31	those	those	DET
bptjm-71	93	32	neurons	neuron	NOUN
bptjm-71	93	33	displayed	display	VERB
bptjm-71	93	34	a	a	DET
bptjm-71	93	35	senescence	senescence	NOUN
bptjm-71	93	36	-	-	PUNCT
bptjm-71	93	37	like	like	ADJ
bptjm-71	93	38	phenotype	phenotype	NOUN
bptjm-71	93	39	.	.	PUNCT
bptjm-71	94	1	this	this	PRON
bptjm-71	94	2	means	mean	VERB
bptjm-71	94	3	that	that	SCONJ
bptjm-71	94	4	the	the	DET
bptjm-71	94	5	gene	gene	NOUN
bptjm-71	94	6	expression	expression	NOUN
bptjm-71	94	7	patterns	pattern	NOUN
bptjm-71	94	8	observed	observe	VERB
bptjm-71	94	9	in	in	ADP
bptjm-71	94	10	these	these	DET
bptjm-71	94	11	neurons	neuron	NOUN
bptjm-71	94	12	resemble	resemble	VERB
bptjm-71	94	13	those	those	PRON
bptjm-71	94	14	typically	typically	ADV
bptjm-71	94	15	seen	see	VERB
bptjm-71	94	16	in	in	ADP
bptjm-71	94	17	senescent	senescent	ADJ
bptjm-71	94	18	cells	cell	NOUN
bptjm-71	94	19	,	,	PUNCT
bptjm-71	94	20	suggesting	suggest	VERB
bptjm-71	94	21	that	that	SCONJ
bptjm-71	94	22	ad	ad	NOUN
bptjm-71	94	23	neurons	neuron	NOUN
bptjm-71	94	24	undergo	undergo	VERB
bptjm-71	94	25	a	a	DET
bptjm-71	94	26	cellular	cellular	ADJ
bptjm-71	94	27	aging	age	VERB
bptjm-71	94	28	process	process	NOUN
bptjm-71	94	29	akin	akin	ADJ
bptjm-71	94	30	to	to	ADP
bptjm-71	94	31	senescence.21	senescence.21	ADJ
bptjm-71	94	32	astrocytes	astrocyte	NOUN
bptjm-71	94	33	tau	tau	PROPN
bptjm-71	94	34	can	can	AUX
bptjm-71	94	35	be	be	AUX
bptjm-71	94	36	transmitted	transmit	VERB
bptjm-71	94	37	from	from	ADP
bptjm-71	94	38	neurons	neuron	NOUN
bptjm-71	94	39	to	to	ADP
bptjm-71	94	40	astrocytes	astrocyte	NOUN
bptjm-71	94	41	,	,	PUNCT
bptjm-71	94	42	causing	cause	VERB
bptjm-71	94	43	the	the	DET
bptjm-71	94	44	astrocytes	astrocyte	NOUN
bptjm-71	94	45	to	to	PART
bptjm-71	94	46	senesce	senesce	VERB
bptjm-71	94	47	and	and	CCONJ
bptjm-71	94	48	produce	produce	VERB
bptjm-71	94	49	sasps	sasp	NOUN
bptjm-71	94	50	.	.	PUNCT
bptjm-71	95	1	studies	study	NOUN
bptjm-71	95	2	have	have	AUX
bptjm-71	95	3	shown	show	VERB
bptjm-71	95	4	that	that	DET
bptjm-71	95	5	astrocyte	astrocyte	NOUN
bptjm-71	95	6	senescence	senescence	NOUN
bptjm-71	95	7	is	be	AUX
bptjm-71	95	8	detrimental	detrimental	ADJ
bptjm-71	95	9	to	to	ADP
bptjm-71	95	10	dendritic	dendritic	ADJ
bptjm-71	95	11	and	and	CCONJ
bptjm-71	95	12	synaptic	synaptic	ADJ
bptjm-71	95	13	structure	structure	NOUN
bptjm-71	95	14	and	and	CCONJ
bptjm-71	95	15	density	density	NOUN
bptjm-71	95	16	.	.	PUNCT
bptjm-71	96	1	this	this	PRON
bptjm-71	96	2	suggests	suggest	VERB
bptjm-71	96	3	that	that	SCONJ
bptjm-71	96	4	pathogenic	pathogenic	ADJ
bptjm-71	96	5	soluble	soluble	ADJ
bptjm-71	96	6	tau	tau	PROPN
bptjm-71	96	7	-	-	PUNCT
bptjm-71	96	8	induced	induce	VERB
bptjm-71	96	9	astrocyte	astrocyte	NOUN
bptjm-71	96	10	senescence	senescence	NOUN
bptjm-71	96	11	may	may	AUX
bptjm-71	96	12	contribute	contribute	VERB
bptjm-71	96	13	to	to	ADP
bptjm-71	96	14	synaptic	synaptic	ADJ
bptjm-71	96	15	dysfunction	dysfunction	NOUN
bptjm-71	96	16	and	and	CCONJ
bptjm-71	96	17	loss	loss	NOUN
bptjm-71	96	18	in	in	ADP
bptjm-71	96	19	ad.33	ad.33	PROPN
bptjm-71	96	20	recent	recent	ADJ
bptjm-71	96	21	research	research	NOUN
bptjm-71	96	22	has	have	AUX
bptjm-71	96	23	highlighted	highlight	VERB
bptjm-71	96	24	that	that	SCONJ
bptjm-71	96	25	tau	tau	PROPN
bptjm-71	96	26	oligomers	oligomer	NOUN
bptjm-71	96	27	play	play	VERB
bptjm-71	96	28	a	a	DET
bptjm-71	96	29	role	role	NOUN
bptjm-71	96	30	in	in	ADP
bptjm-71	96	31	promoting	promote	VERB
bptjm-71	96	32	the	the	DET
bptjm-71	96	33	release	release	NOUN
bptjm-71	96	34	of	of	ADP
bptjm-71	96	35	hmgb1	hmgb1	NOUN
bptjm-71	96	36	from	from	ADP
bptjm-71	96	37	astrocytes	astrocyte	NOUN
bptjm-71	96	38	during	during	ADP
bptjm-71	96	39	inflammation	inflammation	NOUN
bptjm-71	96	40	.	.	PUNCT
bptjm-71	97	1	notably	notably	ADV
bptjm-71	97	2	,	,	PUNCT
bptjm-71	97	3	the	the	DET
bptjm-71	97	4	release	release	NOUN
bptjm-71	97	5	of	of	ADP
bptjm-71	97	6	hmgb1	hmgb1	NOUN
bptjm-71	97	7	not	not	PART
bptjm-71	97	8	only	only	ADV
bptjm-71	97	9	leads	lead	VERB
bptjm-71	97	10	to	to	ADP
bptjm-71	97	11	inflammation	inflammation	NOUN
bptjm-71	97	12	but	but	CCONJ
bptjm-71	97	13	also	also	ADV
bptjm-71	97	14	drives	drive	VERB
bptjm-71	97	15	paracrine	paracrine	ADJ
bptjm-71	97	16	senescence	senescence	NOUN
bptjm-71	97	17	in	in	ADP
bptjm-71	97	18	neighboring	neighbor	VERB
bptjm-71	97	19	cells.27	cells.27	PROPN
bptjm-71	97	20	moreover	moreover	ADV
bptjm-71	97	21	,	,	PUNCT
bptjm-71	97	22	tau	tau	PROPN
bptjm-71	97	23	oligomers	oligomer	NOUN
bptjm-71	97	24	have	have	AUX
bptjm-71	97	25	been	be	AUX
bptjm-71	97	26	specifically	specifically	ADV
bptjm-71	97	27	implicated	implicate	VERB
bptjm-71	97	28	in	in	ADP
bptjm-71	97	29	promoting	promote	VERB
bptjm-71	97	30	the	the	DET
bptjm-71	97	31	aggregation	aggregation	NOUN
bptjm-71	97	32	of	of	ADP
bptjm-71	97	33	p53	p53	NOUN
bptjm-71	97	34	in	in	ADP
bptjm-71	97	35	ad	ad	NOUN
bptjm-71	97	36	patients	patient	NOUN
bptjm-71	97	37	.	.	PUNCT
bptjm-71	98	1	in	in	ADP
bptjm-71	98	2	the	the	DET
bptjm-71	98	3	study	study	NOUN
bptjm-71	98	4	,	,	PUNCT
bptjm-71	98	5	this	this	DET
bptjm-71	98	6	interaction	interaction	NOUN
bptjm-71	98	7	between	between	ADP
bptjm-71	98	8	tau	tau	PROPN
bptjm-71	98	9	oligomers	oligomer	NOUN
bptjm-71	98	10	and	and	CCONJ
bptjm-71	98	11	p53	p53	NOUN
bptjm-71	98	12	was	be	AUX
bptjm-71	98	13	observed	observe	VERB
bptjm-71	98	14	exclusively	exclusively	ADV
bptjm-71	98	15	in	in	ADP
bptjm-71	98	16	ad	ad	NOUN
bptjm-71	98	17	brains	brain	NOUN
bptjm-71	98	18	,	,	PUNCT
bptjm-71	98	19	compared	compare	VERB
bptjm-71	98	20	to	to	ADP
bptjm-71	98	21	control	control	NOUN
bptjm-71	98	22	,	,	PUNCT
bptjm-71	98	23	resulting	result	VERB
bptjm-71	98	24	in	in	ADP
bptjm-71	98	25	the	the	DET
bptjm-71	98	26	sequestration	sequestration	NOUN
bptjm-71	98	27	or	or	CCONJ
bptjm-71	98	28	aggregation	aggregation	NOUN
bptjm-71	98	29	of	of	ADP
bptjm-71	98	30	p53	p53	NOUN
bptjm-71	98	31	outside	outside	ADP
bptjm-71	98	32	the	the	DET
bptjm-71	98	33	nucleus	nucleus	NOUN
bptjm-71	98	34	.	.	PUNCT
bptjm-71	99	1	consequently	consequently	ADV
bptjm-71	99	2	,	,	PUNCT
bptjm-71	99	3	this	this	DET
bptjm-71	99	4	phenomenon	phenomenon	NOUN
bptjm-71	99	5	hinders	hinder	VERB
bptjm-71	99	6	the	the	DET
bptjm-71	99	7	ability	ability	NOUN
bptjm-71	99	8	of	of	ADP
bptjm-71	99	9	p53	p53	NOUN
bptjm-71	99	10	to	to	PART
bptjm-71	99	11	carry	carry	VERB
bptjm-71	99	12	out	out	ADP
bptjm-71	99	13	dna	dna	PROPN
bptjm-71	99	14	repair	repair	NOUN
bptjm-71	99	15	processes	process	NOUN
bptjm-71	99	16	,	,	PUNCT
bptjm-71	99	17	leading	lead	VERB
bptjm-71	99	18	to	to	ADP
bptjm-71	99	19	dna	dna	PROPN
bptjm-71	99	20	damage	damage	NOUN
bptjm-71	99	21	and	and	CCONJ
bptjm-71	99	22	ultimately	ultimately	ADV
bptjm-71	99	23	triggering	trigger	VERB
bptjm-71	99	24	senescence	senescence	NOUN
bptjm-71	99	25	.	.	PUNCT
bptjm-71	100	1	the	the	DET
bptjm-71	100	2	accumulation	accumulation	NOUN
bptjm-71	100	3	of	of	ADP
bptjm-71	100	4	senescent	senescent	ADJ
bptjm-71	100	5	cells	cell	NOUN
bptjm-71	100	6	further	far	ADV
bptjm-71	100	7	exacerbates	exacerbate	VERB
bptjm-71	100	8	the	the	DET
bptjm-71	100	9	progression	progression	NOUN
bptjm-71	100	10	of	of	ADP
bptjm-71	100	11	ad.34	ad.34	PROPN
bptjm-71	100	12	one	one	NUM
bptjm-71	100	13	study	study	NOUN
bptjm-71	100	14	found	find	VERB
bptjm-71	100	15	that	that	SCONJ
bptjm-71	100	16	astrocytes	astrocyte	NOUN
bptjm-71	100	17	and	and	CCONJ
bptjm-71	100	18	microglia	microglia	NOUN
bptjm-71	100	19	are	be	AUX
bptjm-71	100	20	the	the	DET
bptjm-71	100	21	two	two	NUM
bptjm-71	100	22	major	major	ADJ
bptjm-71	100	23	types	type	NOUN
bptjm-71	100	24	of	of	ADP
bptjm-71	100	25	senescent	senescent	ADJ
bptjm-71	100	26	cells	cell	NOUN
bptjm-71	100	27	that	that	PRON
bptjm-71	100	28	accumulate	accumulate	VERB
bptjm-71	100	29	in	in	ADP
bptjm-71	100	30	the	the	DET
bptjm-71	100	31	dentate	dentate	ADJ
bptjm-71	100	32	gyrus	gyrus	NOUN
bptjm-71	100	33	of	of	ADP
bptjm-71	100	34	the	the	DET
bptjm-71	100	35	hippocampus	hippocampus	NOUN
bptjm-71	100	36	in	in	ADP
bptjm-71	100	37	ad.20	ad.20	PROPN
bptjm-71	100	38	this	this	PRON
bptjm-71	100	39	was	be	AUX
bptjm-71	100	40	supported	support	VERB
bptjm-71	100	41	by	by	ADP
bptjm-71	100	42	the	the	DET
bptjm-71	100	43	laboratory	laboratory	NOUN
bptjm-71	100	44	of	of	ADP
bptjm-71	100	45	human	human	ADJ
bptjm-71	100	46	carcinogenesis	carcinogenesis	NOUN
bptjm-71	100	47	,	,	PUNCT
bptjm-71	100	48	where	where	SCONJ
bptjm-71	100	49	they	they	PRON
bptjm-71	100	50	found	find	VERB
bptjm-71	100	51	that	that	SCONJ
bptjm-71	100	52	astrocytes	astrocyte	NOUN
bptjm-71	100	53	are	be	AUX
bptjm-71	100	54	the	the	DET
bptjm-71	100	55	primary	primary	ADJ
bptjm-71	100	56	type	type	NOUN
bptjm-71	100	57	of	of	ADP
bptjm-71	100	58	senescent	senescent	ADJ
bptjm-71	100	59	cells	cell	NOUN
bptjm-71	100	60	present	present	ADJ
bptjm-71	100	61	in	in	ADP
bptjm-71	100	62	patients	patient	NOUN
bptjm-71	100	63	with	with	ADP
bptjm-71	100	64	ad	ad	NOUN
bptjm-71	100	65	,	,	PUNCT
bptjm-71	100	66	amyotrophic	amyotrophic	ADJ
bptjm-71	100	67	lateral	lateral	ADJ
bptjm-71	100	68	sclerosis	sclerosis	NOUN
bptjm-71	100	69	(	(	PUNCT
bptjm-71	100	70	als	als	NOUN
bptjm-71	100	71	)	)	PUNCT
bptjm-71	100	72	,	,	PUNCT
bptjm-71	100	73	aged	aged	ADJ
bptjm-71	100	74	individuals	individual	NOUN
bptjm-71	100	75	and	and	CCONJ
bptjm-71	100	76	those	those	PRON
bptjm-71	100	77	receiving	receive	VERB
bptjm-71	100	78	cranial	cranial	NOUN
bptjm-71	100	79	radiation.4	radiation.4	ADP
bptjm-71	100	80	flow	flow	NOUN
bptjm-71	100	81	cytometry	cytometry	NOUN
bptjm-71	100	82	analysis	analysis	NOUN
bptjm-71	100	83	of	of	ADP
bptjm-71	100	84	ps19	ps19	PROPN
bptjm-71	100	85	mouse	mouse	NOUN
bptjm-71	100	86	models	model	NOUN
bptjm-71	100	87	,	,	PUNCT
bptjm-71	100	88	which	which	PRON
bptjm-71	100	89	overexpress	overexpress	VERB
bptjm-71	100	90	human	human	ADJ
bptjm-71	100	91	mutant	mutant	NOUN
bptjm-71	100	92	tau	tau	PROPN
bptjm-71	100	93	,	,	PUNCT
bptjm-71	100	94	also	also	ADV
bptjm-71	100	95	validated	validate	VERB
bptjm-71	100	96	these	these	DET
bptjm-71	100	97	findings	finding	NOUN
bptjm-71	100	98	by	by	ADP
bptjm-71	100	99	berkeley	berkeley	PROPN
bptjm-71	100	100	pharma	pharma	PROPN
bptjm-71	100	101	tech	tech	NOUN
bptjm-71	100	102	journal	journal	NOUN
bptjm-71	100	103	of	of	ADP
bptjm-71	100	104	medicine	medicine	NOUN
bptjm-71	100	105	|	|	ADV
bptjm-71	100	106	53	53	NUM
bptjm-71	100	107	revealing	reveal	VERB
bptjm-71	100	108	increased	increase	VERB
bptjm-71	100	109	expression	expression	NOUN
bptjm-71	100	110	of	of	ADP
bptjm-71	100	111	senescence	senescence	NOUN
bptjm-71	100	112	-	-	PUNCT
bptjm-71	100	113	associated	associate	VERB
bptjm-71	100	114	genes	gene	NOUN
bptjm-71	100	115	,	,	PUNCT
bptjm-71	100	116	including	include	VERB
bptjm-71	100	117	p16ink4a	p16ink4a	PROPN
bptjm-71	100	118	,	,	PUNCT
bptjm-71	100	119	in	in	ADP
bptjm-71	100	120	isolated	isolated	ADJ
bptjm-71	100	121	astrocytes	astrocyte	NOUN
bptjm-71	100	122	and	and	CCONJ
bptjm-71	100	123	microglia	microglia	ADJ
bptjm-71	100	124	,	,	PUNCT
bptjm-71	100	125	while	while	SCONJ
bptjm-71	100	126	olgs	olgs	NOUN
bptjm-71	100	127	and	and	CCONJ
bptjm-71	100	128	neurons	neuron	NOUN
bptjm-71	100	129	did	do	AUX
bptjm-71	100	130	not	not	PART
bptjm-71	100	131	exhibit	exhibit	VERB
bptjm-71	100	132	the	the	DET
bptjm-71	100	133	same	same	ADJ
bptjm-71	100	134	upregulation	upregulation	NOUN
bptjm-71	100	135	.	.	PUNCT
bptjm-71	101	1	furthermore	furthermore	ADV
bptjm-71	101	2	,	,	PUNCT
bptjm-71	101	3	the	the	DET
bptjm-71	101	4	study	study	NOUN
bptjm-71	101	5	reported	report	VERB
bptjm-71	101	6	that	that	SCONJ
bptjm-71	101	7	senescent	senescent	ADJ
bptjm-71	101	8	astrocytes	astrocyte	NOUN
bptjm-71	101	9	and	and	CCONJ
bptjm-71	101	10	microglia	microglia	NOUN
bptjm-71	101	11	exhibit	exhibit	VERB
bptjm-71	101	12	inflammatory	inflammatory	ADJ
bptjm-71	101	13	reactions	reaction	NOUN
bptjm-71	101	14	to	to	ADP
bptjm-71	101	15	extracellular	extracellular	ADJ
bptjm-71	101	16	tau	tau	PROPN
bptjm-71	101	17	,	,	PUNCT
bptjm-71	101	18	leading	lead	VERB
bptjm-71	101	19	to	to	ADP
bptjm-71	101	20	damaged	damage	VERB
bptjm-71	101	21	neurons.20	neurons.20	NOUN
bptjm-71	101	22	in	in	ADP
bptjm-71	101	23	the	the	DET
bptjm-71	101	24	context	context	NOUN
bptjm-71	101	25	of	of	ADP
bptjm-71	101	26	neuronal	neuronal	ADJ
bptjm-71	101	27	damage	damage	NOUN
bptjm-71	101	28	,	,	PUNCT
bptjm-71	101	29	it	it	PRON
bptjm-71	101	30	has	have	AUX
bptjm-71	101	31	been	be	AUX
bptjm-71	101	32	identified	identify	VERB
bptjm-71	101	33	that	that	PRON
bptjm-71	101	34	astrocyte	astrocyte	NOUN
bptjm-71	101	35	senescence	senescence	NOUN
bptjm-71	101	36	is	be	AUX
bptjm-71	101	37	associated	associate	VERB
bptjm-71	101	38	with	with	ADP
bptjm-71	101	39	the	the	DET
bptjm-71	101	40	downregulation	downregulation	NOUN
bptjm-71	101	41	of	of	ADP
bptjm-71	101	42	glutamate	glutamate	NOUN
bptjm-71	101	43	and	and	CCONJ
bptjm-71	101	44	potassium	potassium	NOUN
bptjm-71	101	45	transporter	transporter	NOUN
bptjm-71	101	46	genes	gene	NOUN
bptjm-71	101	47	.	.	PUNCT
bptjm-71	102	1	consequently	consequently	ADV
bptjm-71	102	2	,	,	PUNCT
bptjm-71	102	3	this	this	DET
bptjm-71	102	4	impairment	impairment	NOUN
bptjm-71	102	5	of	of	ADP
bptjm-71	102	6	glutamate	glutamate	ADJ
bptjm-71	102	7	clearance	clearance	NOUN
bptjm-71	102	8	increased	increase	VERB
bptjm-71	102	9	susceptibility	susceptibility	NOUN
bptjm-71	102	10	of	of	ADP
bptjm-71	102	11	neurons	neuron	NOUN
bptjm-71	102	12	to	to	ADP
bptjm-71	102	13	glutamate	glutamate	VERB
bptjm-71	102	14	-	-	PUNCT
bptjm-71	102	15	induced	induce	VERB
bptjm-71	102	16	toxicity	toxicity	NOUN
bptjm-71	102	17	and	and	CCONJ
bptjm-71	102	18	ultimately	ultimately	ADV
bptjm-71	102	19	neuronal	neuronal	ADJ
bptjm-71	102	20	cell	cell	NOUN
bptjm-71	102	21	death	death	NOUN
bptjm-71	102	22	(	(	PUNCT
bptjm-71	102	23	fig	fig	NOUN
bptjm-71	102	24	.	.	PUNCT
bptjm-71	103	1	3).35	3).35	NUM
bptjm-71	103	2	microglial	microglial	NOUN
bptjm-71	103	3	in	in	ADP
bptjm-71	103	4	the	the	DET
bptjm-71	103	5	aged	aged	ADJ
bptjm-71	103	6	human	human	ADJ
bptjm-71	103	7	brain	brain	NOUN
bptjm-71	103	8	,	,	PUNCT
bptjm-71	103	9	many	many	ADJ
bptjm-71	103	10	microglial	microglial	ADJ
bptjm-71	103	11	cells	cell	NOUN
bptjm-71	103	12	showmorphological	showmorphological	ADJ
bptjm-71	103	13	features	feature	NOUN
bptjm-71	103	14	indicative	indicative	ADJ
bptjm-71	103	15	of	of	ADP
bptjm-71	103	16	senescence	senescence	NOUN
bptjm-71	103	17	or	or	CCONJ
bptjm-71	103	18	degeneration	degeneration	NOUN
bptjm-71	103	19	rather	rather	ADV
bptjm-71	103	20	than	than	ADP
bptjm-71	103	21	activation	activation	NOUN
bptjm-71	103	22	.	.	PUNCT
bptjm-71	104	1	this	this	PRON
bptjm-71	104	2	suggests	suggest	VERB
bptjm-71	104	3	that	that	SCONJ
bptjm-71	104	4	microglial	microglial	ADJ
bptjm-71	104	5	senescence	senescence	NOUN
bptjm-71	104	6	and	and	CCONJ
bptjm-71	104	7	associated	associate	VERB
bptjm-71	104	8	loss	loss	NOUN
bptjm-71	104	9	of	of	ADP
bptjm-71	104	10	neuroprotection	neuroprotection	NOUN
bptjm-71	104	11	could	could	AUX
bptjm-71	104	12	be	be	AUX
bptjm-71	104	13	involved	involve	VERB
bptjm-71	104	14	in	in	ADP
bptjm-71	104	15	aging	age	VERB
bptjm-71	104	16	-	-	PUNCT
bptjm-71	104	17	related	relate	VERB
bptjm-71	104	18	neurodegenerative	neurodegenerative	ADJ
bptjm-71	104	19	diseases	disease	NOUN
bptjm-71	104	20	.	.	PUNCT
bptjm-71	105	1	in	in	ADP
bptjm-71	105	2	fact	fact	NOUN
bptjm-71	105	3	,	,	PUNCT
bptjm-71	105	4	streit	streit	PROPN
bptjm-71	105	5	et	et	PROPN
bptjm-71	105	6	al	al	PROPN
bptjm-71	105	7	.	.	PROPN
bptjm-71	105	8	reports	report	VERB
bptjm-71	105	9	that	that	SCONJ
bptjm-71	105	10	dystrophic	dystrophic	ADJ
bptjm-71	105	11	microglial	microglial	ADJ
bptjm-71	105	12	cells	cell	NOUN
bptjm-71	105	13	are	be	AUX
bptjm-71	105	14	implicated	implicate	VERB
bptjm-71	105	15	in	in	ADP
bptjm-71	105	16	the	the	DET
bptjm-71	105	17	development	development	NOUN
bptjm-71	105	18	of	of	ADP
bptjm-71	105	19	ad	ad	NOUN
bptjm-71	105	20	,	,	PUNCT
bptjm-71	105	21	associated	associate	VERB
bptjm-71	105	22	with	with	ADP
bptjm-71	105	23	severe	severe	ADJ
bptjm-71	105	24	tau	tau	PROPN
bptjm-71	105	25	pathology	pathology	NOUN
bptjm-71	105	26	.	.	PUNCT
bptjm-71	106	1	investigation	investigation	NOUN
bptjm-71	106	2	of	of	ADP
bptjm-71	106	3	microglial	microglial	ADJ
bptjm-71	106	4	dysfunction	dysfunction	NOUN
bptjm-71	106	5	by	by	ADP
bptjm-71	106	6	examining	examine	VERB
bptjm-71	106	7	their	their	PRON
bptjm-71	106	8	morphology	morphology	NOUN
bptjm-71	106	9	in	in	ADP
bptjm-71	106	10	the	the	DET
bptjm-71	106	11	vicinity	vicinity	NOUN
bptjm-71	106	12	of	of	ADP
bptjm-71	106	13	tau	tau	PROPN
bptjm-71	106	14	-	-	PUNCT
bptjm-71	106	15	positive	positive	ADJ
bptjm-71	106	16	structures	structure	NOUN
bptjm-71	106	17	revealed	reveal	VERB
bptjm-71	106	18	that	that	SCONJ
bptjm-71	106	19	microglial	microglial	ADJ
bptjm-71	106	20	degeneration	degeneration	NOUN
bptjm-71	106	21	may	may	AUX
bptjm-71	106	22	precede	precede	VERB
bptjm-71	106	23	the	the	DET
bptjm-71	106	24	onset	onset	NOUN
bptjm-71	106	25	of	of	ADP
bptjm-71	106	26	nft	nft	PROPN
bptjm-71	106	27	pathology	pathology	PROPN
bptjm-71	106	28	,	,	PUNCT
bptjm-71	106	29	meaning	mean	VERB
bptjm-71	106	30	that	that	SCONJ
bptjm-71	106	31	the	the	DET
bptjm-71	106	32	loss	loss	NOUN
bptjm-71	106	33	of	of	ADP
bptjm-71	106	34	microglial	microglial	ADJ
bptjm-71	106	35	structural	structural	ADJ
bptjm-71	106	36	integrity	integrity	NOUN
bptjm-71	106	37	contributes	contribute	VERB
bptjm-71	106	38	to	to	ADP
bptjm-71	106	39	neurodegeneration.36	neurodegeneration.36	PROPN
bptjm-71	106	40	karabag	karabag	PROPN
bptjm-71	106	41	et	et	PROPN
bptjm-71	106	42	al	al	PROPN
bptjm-71	106	43	.	.	PROPN
bptjm-71	106	44	conducted	conduct	VERB
bptjm-71	106	45	a	a	DET
bptjm-71	106	46	study	study	NOUN
bptjm-71	106	47	demonstrating	demonstrate	VERB
bptjm-71	106	48	that	that	DET
bptjm-71	106	49	exposure	exposure	NOUN
bptjm-71	106	50	to	to	ADP
bptjm-71	106	51	tau	tau	PROPN
bptjm-71	106	52	can	can	AUX
bptjm-71	106	53	induce	induce	VERB
bptjm-71	106	54	microglial	microglial	ADJ
bptjm-71	106	55	senescence	senescence	NOUN
bptjm-71	106	56	.	.	PUNCT
bptjm-71	107	1	specifically	specifically	ADV
bptjm-71	107	2	,	,	PUNCT
bptjm-71	107	3	they	they	PRON
bptjm-71	107	4	found	find	VERB
bptjm-71	107	5	that	that	SCONJ
bptjm-71	107	6	an	an	DET
bptjm-71	107	7	exposure	exposure	NOUN
bptjm-71	107	8	to	to	ADP
bptjm-71	107	9	15	15	NUM
bptjm-71	107	10	nm	nm	PRON
bptjm-71	107	11	concentration	concentration	NOUN
bptjm-71	107	12	of	of	ADP
bptjm-71	107	13	tau	tau	PROPN
bptjm-71	107	14	resulted	result	VERB
bptjm-71	107	15	in	in	ADP
bptjm-71	107	16	increased	increase	VERB
bptjm-71	107	17	levels	level	NOUN
bptjm-71	107	18	of	of	ADP
bptjm-71	107	19	cell	cell	NOUN
bptjm-71	107	20	cycle	cycle	NOUN
bptjm-71	107	21	arrest	arrest	NOUN
bptjm-71	107	22	and	and	CCONJ
bptjm-71	107	23	a	a	DET
bptjm-71	107	24	dna	dna	PROPN
bptjm-71	107	25	damage	damage	NOUN
bptjm-71	107	26	marker	marker	NOUN
bptjm-71	107	27	.	.	PUNCT
bptjm-71	108	1	it	it	PRON
bptjm-71	108	2	also	also	ADV
bptjm-71	108	3	led	lead	VERB
bptjm-71	108	4	to	to	ADP
bptjm-71	108	5	the	the	DET
bptjm-71	108	6	loss	loss	NOUN
bptjm-71	108	7	of	of	ADP
bptjm-71	108	8	nuclear	nuclear	ADJ
bptjm-71	108	9	envelope	envelope	NOUN
bptjm-71	108	10	protein	protein	NOUN
bptjm-71	108	11	lamin	lamin	NOUN
bptjm-71	108	12	b1	b1	NOUN
bptjm-71	108	13	and	and	CCONJ
bptjm-71	108	14	the	the	DET
bptjm-71	108	15	histone	histone	NOUN
bptjm-71	108	16	marker	marker	NOUN
bptjm-71	108	17	h3k9me3	h3k9me3	ADP
bptjm-71	108	18	,	,	PUNCT
bptjm-71	108	19	thereby	thereby	ADV
bptjm-71	108	20	affecting	affect	VERB
bptjm-71	108	21	the	the	DET
bptjm-71	108	22	clearance	clearance	NOUN
bptjm-71	108	23	of	of	ADP
bptjm-71	108	24	tau	tau	PROPN
bptjm-71	108	25	and	and	CCONJ
bptjm-71	108	26	impairing	impair	VERB
bptjm-71	108	27	cell	cell	NOUN
bptjm-71	108	28	migration	migration	NOUN
bptjm-71	108	29	(	(	PUNCT
bptjm-71	108	30	fig.3	fig.3	PROPN
bptjm-71	108	31	)	)	PUNCT
bptjm-71	108	32	.	.	PUNCT
bptjm-71	109	1	additionally	additionally	ADV
bptjm-71	109	2	,	,	PUNCT
bptjm-71	109	3	this	this	DET
bptjm-71	109	4	exposure	exposure	NOUN
bptjm-71	109	5	caused	cause	VERB
bptjm-71	109	6	alterations	alteration	NOUN
bptjm-71	109	7	in	in	ADP
bptjm-71	109	8	cell	cell	NOUN
bptjm-71	109	9	morphology	morphology	NOUN
bptjm-71	109	10	and	and	CCONJ
bptjm-71	109	11	triggered	trigger	VERB
bptjm-71	109	12	the	the	DET
bptjm-71	109	13	formation	formation	NOUN
bptjm-71	109	14	of	of	ADP
bptjm-71	109	15	a	a	DET
bptjm-71	109	16	sasp.24	sasp.24	NOUN
bptjm-71	109	17	oligodendrocytes	oligodendrocyte	VERB
bptjm-71	109	18	tauopathies	tauopathie	NOUN
bptjm-71	109	19	involving	involve	VERB
bptjm-71	109	20	olgs	olgs	NOUN
bptjm-71	109	21	have	have	AUX
bptjm-71	109	22	been	be	AUX
bptjm-71	109	23	identified	identify	VERB
bptjm-71	109	24	in	in	ADP
bptjm-71	109	25	specific	specific	ADJ
bptjm-71	109	26	dementias	dementia	NOUN
bptjm-71	109	27	,	,	PUNCT
bptjm-71	109	28	such	such	ADJ
bptjm-71	109	29	as	as	ADP
bptjm-71	109	30	progressive	progressive	ADJ
bptjm-71	109	31	supranuclear	supranuclear	ADJ
bptjm-71	109	32	palsy	palsy	ADJ
bptjm-71	109	33	(	(	PUNCT
bptjm-71	109	34	psp	psp	NOUN
bptjm-71	109	35	)	)	PUNCT
bptjm-71	109	36	,	,	PUNCT
bptjm-71	109	37	corticobasal	corticobasal	NOUN
bptjm-71	109	38	degeneration	degeneration	NOUN
bptjm-71	109	39	,	,	PUNCT
bptjm-71	109	40	and	and	CCONJ
bptjm-71	109	41	frontotemporal	frontotemporal	ADJ
bptjm-71	109	42	dementia	dementia	NOUN
bptjm-71	109	43	,	,	PUNCT
bptjm-71	109	44	which	which	PRON
bptjm-71	109	45	includes	include	VERB
bptjm-71	109	46	pick	pick	NOUN
bptjm-71	109	47	's	's	PART
bptjm-71	109	48	disease	disease	NOUN
bptjm-71	109	49	and	and	CCONJ
bptjm-71	109	50	certain	certain	ADJ
bptjm-71	109	51	cases	case	NOUN
bptjm-71	109	52	of	of	ADP
bptjm-71	109	53	ad.37	ad.37	NOUN
bptjm-71	109	54	because	because	SCONJ
bptjm-71	109	55	pathological	pathological	ADJ
bptjm-71	109	56	tau	tau	PROPN
bptjm-71	109	57	has	have	VERB
bptjm-71	109	58	the	the	DET
bptjm-71	109	59	ability	ability	NOUN
bptjm-71	109	60	to	to	PART
bptjm-71	109	61	propagate	propagate	VERB
bptjm-71	109	62	from	from	ADP
bptjm-71	109	63	neurons	neuron	NOUN
bptjm-71	109	64	to	to	ADP
bptjm-71	109	65	other	other	ADJ
bptjm-71	109	66	cell	cell	NOUN
bptjm-71	109	67	types	type	NOUN
bptjm-71	109	68	both	both	CCONJ
bptjm-71	109	69	trans	tran	NOUN
bptjm-71	109	70	-	-	ADJ
bptjm-71	109	71	cellularly	cellularly	ADJ
bptjm-71	109	72	and	and	CCONJ
bptjm-71	109	73	trans	tran	NOUN
bptjm-71	109	74	-	-	PUNCT
bptjm-71	109	75	synaptically	synaptically	ADV
bptjm-71	109	76	,	,	PUNCT
bptjm-71	109	77	it	it	PRON
bptjm-71	109	78	can	can	AUX
bptjm-71	109	79	contribute	contribute	VERB
bptjm-71	109	80	berkeley	berkeley	PROPN
bptjm-71	109	81	pharma	pharma	PROPN
bptjm-71	109	82	tech	tech	NOUN
bptjm-71	109	83	journal	journal	NOUN
bptjm-71	109	84	of	of	ADP
bptjm-71	109	85	medicine	medicine	NOUN
bptjm-71	109	86	|	|	ADV
bptjm-71	109	87	54	54	NUM
bptjm-71	109	88	to	to	ADP
bptjm-71	109	89	the	the	DET
bptjm-71	109	90	spread	spread	NOUN
bptjm-71	109	91	of	of	ADP
bptjm-71	109	92	neurodegenerative	neurodegenerative	ADJ
bptjm-71	109	93	disease.38	disease.38	PROPN
bptjm-71	109	94	however	however	ADV
bptjm-71	109	95	,	,	PUNCT
bptjm-71	109	96	studies	study	NOUN
bptjm-71	109	97	now	now	ADV
bptjm-71	109	98	propose	propose	VERB
bptjm-71	109	99	that	that	SCONJ
bptjm-71	109	100	olgs	olgs	NOUN
bptjm-71	109	101	can	can	AUX
bptjm-71	109	102	contribute	contribute	VERB
bptjm-71	109	103	to	to	ADP
bptjm-71	109	104	the	the	DET
bptjm-71	109	105	spread	spread	NOUN
bptjm-71	109	106	of	of	ADP
bptjm-71	109	107	tau	tau	PROPN
bptjm-71	109	108	without	without	ADP
bptjm-71	109	109	passing	pass	VERB
bptjm-71	109	110	through	through	ADP
bptjm-71	109	111	intra	intra	ADJ
bptjm-71	109	112	-	-	ADJ
bptjm-71	109	113	neuronal	neuronal	ADJ
bptjm-71	109	114	transport	transport	NOUN
bptjm-71	109	115	in	in	ADP
bptjm-71	109	116	a	a	DET
bptjm-71	109	117	glial	glial	ADJ
bptjm-71	109	118	-	-	PUNCT
bptjm-71	109	119	to	to	ADP
bptjm-71	109	120	-	-	PUNCT
bptjm-71	109	121	glial	glial	ADJ
bptjm-71	109	122	fashion	fashion	NOUN
bptjm-71	109	123	,	,	PUNCT
bptjm-71	109	124	playing	play	VERB
bptjm-71	109	125	a	a	DET
bptjm-71	109	126	further	further	ADJ
bptjm-71	109	127	role	role	NOUN
bptjm-71	109	128	in	in	ADP
bptjm-71	109	129	the	the	DET
bptjm-71	109	130	spreading	spreading	NOUN
bptjm-71	109	131	of	of	ADP
bptjm-71	109	132	tauopathies.39	tauopathies.39	NOUN
bptjm-71	109	133	the	the	DET
bptjm-71	109	134	spread	spread	NOUN
bptjm-71	109	135	of	of	ADP
bptjm-71	109	136	tau	tau	PROPN
bptjm-71	109	137	pathology	pathology	NOUN
bptjm-71	109	138	to	to	PART
bptjm-71	109	139	olgs	olgs	NOUN
bptjm-71	109	140	is	be	AUX
bptjm-71	109	141	closely	closely	ADV
bptjm-71	109	142	linked	link	VERB
bptjm-71	109	143	to	to	ADP
bptjm-71	109	144	the	the	DET
bptjm-71	109	145	loss	loss	NOUN
bptjm-71	109	146	of	of	ADP
bptjm-71	109	147	high	high	ADJ
bptjm-71	109	148	-	-	PUNCT
bptjm-71	109	149	firing	firing	NOUN
bptjm-71	109	150	pyramidal	pyramidal	ADJ
bptjm-71	109	151	neurons	neuron	NOUN
bptjm-71	109	152	,	,	PUNCT
bptjm-71	109	153	a	a	DET
bptjm-71	109	154	crucial	crucial	ADJ
bptjm-71	109	155	neuron	neuron	NOUN
bptjm-71	109	156	type	type	NOUN
bptjm-71	109	157	essential	essential	ADJ
bptjm-71	109	158	for	for	ADP
bptjm-71	109	159	cognitive	cognitive	ADJ
bptjm-71	109	160	function	function	NOUN
bptjm-71	109	161	.	.	PUNCT
bptjm-71	110	1	the	the	DET
bptjm-71	110	2	depletion	depletion	NOUN
bptjm-71	110	3	of	of	ADP
bptjm-71	110	4	these	these	DET
bptjm-71	110	5	neurons	neuron	NOUN
bptjm-71	110	6	can	can	AUX
bptjm-71	110	7	lead	lead	VERB
bptjm-71	110	8	to	to	ADP
bptjm-71	110	9	cognitive	cognitive	ADJ
bptjm-71	110	10	decline	decline	NOUN
bptjm-71	110	11	,	,	PUNCT
bptjm-71	110	12	as	as	SCONJ
bptjm-71	110	13	assessed	assess	VERB
bptjm-71	110	14	through	through	ADP
bptjm-71	110	15	various	various	ADJ
bptjm-71	110	16	behavioral	behavioral	ADJ
bptjm-71	110	17	tests	test	NOUN
bptjm-71	110	18	in	in	ADP
bptjm-71	110	19	mice	mouse	NOUN
bptjm-71	110	20	.	.	PUNCT
bptjm-71	111	1	in	in	ADP
bptjm-71	111	2	one	one	NUM
bptjm-71	111	3	study	study	NOUN
bptjm-71	111	4	,	,	PUNCT
bptjm-71	111	5	mice	mouse	NOUN
bptjm-71	111	6	injected	inject	VERB
bptjm-71	111	7	with	with	ADP
bptjm-71	111	8	human	human	ADJ
bptjm-71	111	9	tau	tau	PROPN
bptjm-71	111	10	aggregates	aggregate	NOUN
bptjm-71	111	11	displayed	display	VERB
bptjm-71	111	12	prolonged	prolonged	ADJ
bptjm-71	111	13	search	search	NOUN
bptjm-71	111	14	times	time	NOUN
bptjm-71	111	15	in	in	ADP
bptjm-71	111	16	locating	locate	VERB
bptjm-71	111	17	the	the	DET
bptjm-71	111	18	platform	platform	NOUN
bptjm-71	111	19	in	in	ADP
bptjm-71	111	20	the	the	DET
bptjm-71	111	21	morris	morris	PROPN
bptjm-71	111	22	water	water	NOUN
bptjm-71	111	23	maze	maze	NOUN
bptjm-71	111	24	,	,	PUNCT
bptjm-71	111	25	reduced	reduce	VERB
bptjm-71	111	26	visits	visit	NOUN
bptjm-71	111	27	to	to	ADP
bptjm-71	111	28	the	the	DET
bptjm-71	111	29	correct	correct	ADJ
bptjm-71	111	30	arm	arm	NOUN
bptjm-71	111	31	in	in	ADP
bptjm-71	111	32	the	the	DET
bptjm-71	111	33	y	y	PROPN
bptjm-71	111	34	-maze	-maze	NOUN
bptjm-71	111	35	,	,	PUNCT
bptjm-71	111	36	and	and	CCONJ
bptjm-71	111	37	decreased	decrease	VERB
bptjm-71	111	38	exploration	exploration	NOUN
bptjm-71	111	39	time	time	NOUN
bptjm-71	111	40	of	of	ADP
bptjm-71	111	41	the	the	DET
bptjm-71	111	42	novel	novel	ADJ
bptjm-71	111	43	object	object	NOUN
bptjm-71	111	44	compared	compare	VERB
bptjm-71	111	45	to	to	PART
bptjm-71	111	46	control	control	VERB
bptjm-71	111	47	mice.37	mice.37	VERB
bptjm-71	111	48	the	the	DET
bptjm-71	111	49	aggregation	aggregation	NOUN
bptjm-71	111	50	of	of	ADP
bptjm-71	111	51	tau	tau	PROPN
bptjm-71	111	52	in	in	ADP
bptjm-71	111	53	olgs	olgs	NOUN
bptjm-71	111	54	may	may	AUX
bptjm-71	111	55	be	be	AUX
bptjm-71	111	56	a	a	DET
bptjm-71	111	57	contributing	contribute	VERB
bptjm-71	111	58	factor	factor	NOUN
bptjm-71	111	59	to	to	ADP
bptjm-71	111	60	the	the	DET
bptjm-71	111	61	development	development	NOUN
bptjm-71	111	62	of	of	ADP
bptjm-71	111	63	gait	gait	ADJ
bptjm-71	111	64	abnormalities	abnormality	NOUN
bptjm-71	111	65	and	and	CCONJ
bptjm-71	111	66	myelin	myelin	NOUN
bptjm-71	111	67	loss	loss	NOUN
bptjm-71	111	68	in	in	ADP
bptjm-71	111	69	neurodegenerative	neurodegenerative	ADJ
bptjm-71	111	70	diseases	disease	NOUN
bptjm-71	111	71	(	(	PUNCT
bptjm-71	111	72	fig	fig	NOUN
bptjm-71	111	73	.	.	PUNCT
bptjm-71	112	1	3).30	3).30	NUM
bptjm-71	112	2	in	in	ADP
bptjm-71	112	3	fact	fact	NOUN
bptjm-71	112	4	,	,	PUNCT
bptjm-71	112	5	luo	luo	PROPN
bptjm-71	112	6	et	et	PROPN
bptjm-71	112	7	al	al	PROPN
bptjm-71	112	8	.	.	PROPN
bptjm-71	112	9	,	,	PUNCT
bptjm-71	112	10	found	find	VERB
bptjm-71	112	11	that	that	SCONJ
bptjm-71	112	12	olg	olg	VERB
bptjm-71	112	13	lineage	lineage	NOUN
bptjm-71	112	14	cells	cell	NOUN
bptjm-71	112	15	from	from	ADP
bptjm-71	112	16	old	old	ADJ
bptjm-71	112	17	donors	donor	NOUN
bptjm-71	112	18	had	have	VERB
bptjm-71	112	19	lower	low	ADJ
bptjm-71	112	20	myelination	myelination	NOUN
bptjm-71	112	21	potential	potential	NOUN
bptjm-71	112	22	than	than	ADP
bptjm-71	112	23	olg	olg	NOUN
bptjm-71	112	24	lineage	lineage	NOUN
bptjm-71	112	25	cells	cell	NOUN
bptjm-71	112	26	from	from	ADP
bptjm-71	112	27	younger	young	ADJ
bptjm-71	112	28	donors.40	donors.40	NOUN
bptjm-71	112	29	figure	figure	NOUN
bptjm-71	112	30	3	3	NUM
bptjm-71	112	31	:	:	PUNCT
bptjm-71	112	32	cellular	cellular	ADJ
bptjm-71	112	33	morphological	morphological	ADJ
bptjm-71	112	34	changes	change	NOUN
bptjm-71	112	35	in	in	ADP
bptjm-71	112	36	senescence	senescence	NOUN
bptjm-71	112	37	.	.	PUNCT
bptjm-71	113	1	senescent	senescent	ADJ
bptjm-71	113	2	cells	cell	NOUN
bptjm-71	113	3	undergo	undergo	VERB
bptjm-71	113	4	morphological	morphological	ADJ
bptjm-71	113	5	changes	change	NOUN
bptjm-71	113	6	,	,	PUNCT
bptjm-71	113	7	such	such	ADJ
bptjm-71	113	8	as	as	ADP
bptjm-71	113	9	altered	alter	VERB
bptjm-71	113	10	cell	cell	NOUN
bptjm-71	113	11	size	size	NOUN
bptjm-71	113	12	and	and	CCONJ
bptjm-71	113	13	structure	structure	NOUN
bptjm-71	113	14	,	,	PUNCT
bptjm-71	113	15	that	that	PRON
bptjm-71	113	16	lead	lead	VERB
bptjm-71	113	17	to	to	ADP
bptjm-71	113	18	neurodegeneration	neurodegeneration	NOUN
bptjm-71	113	19	.	.	PUNCT
bptjm-71	114	1	these	these	DET
bptjm-71	114	2	cellular	cellular	ADJ
bptjm-71	114	3	changes	change	NOUN
bptjm-71	114	4	make	make	VERB
bptjm-71	114	5	up	up	ADP
bptjm-71	114	6	a	a	DET
bptjm-71	114	7	vicious	vicious	ADJ
bptjm-71	114	8	cycle	cycle	NOUN
bptjm-71	114	9	as	as	SCONJ
bptjm-71	114	10	they	they	PRON
bptjm-71	114	11	contribute	contribute	VERB
bptjm-71	114	12	to	to	ADP
bptjm-71	114	13	the	the	DET
bptjm-71	114	14	propagation	propagation	NOUN
bptjm-71	114	15	of	of	ADP
bptjm-71	114	16	other	other	ADJ
bptjm-71	114	17	senescent	senescent	ADJ
bptjm-71	114	18	cells	cell	NOUN
bptjm-71	114	19	.	.	PUNCT
bptjm-71	115	1	berkeley	berkeley	PROPN
bptjm-71	115	2	pharma	pharma	PROPN
bptjm-71	115	3	tech	tech	PROPN
bptjm-71	115	4	journal	journal	NOUN
bptjm-71	115	5	of	of	ADP
bptjm-71	115	6	medicine	medicine	NOUN
bptjm-71	115	7	|	|	ADV
bptjm-71	115	8	55	55	NUM
bptjm-71	115	9	3	3	NUM
bptjm-71	115	10	.	.	PUNCT
bptjm-71	116	1	therapeutic	therapeutic	ADJ
bptjm-71	116	2	approaches	approach	NOUN
bptjm-71	116	3	3.1	3.1	NUM
bptjm-71	116	4	.	.	PUNCT
bptjm-71	117	1	senolytics	senolytic	NOUN
bptjm-71	117	2	senolytics	senolytic	NOUN
bptjm-71	117	3	eliminate	eliminate	VERB
bptjm-71	117	4	senescent	senescent	ADJ
bptjm-71	117	5	cells	cell	NOUN
bptjm-71	117	6	by	by	ADP
bptjm-71	117	7	inducing	induce	VERB
bptjm-71	117	8	apoptosis	apoptosis	NOUN
bptjm-71	117	9	.	.	PUNCT
bptjm-71	118	1	this	this	PRON
bptjm-71	118	2	is	be	AUX
bptjm-71	118	3	done	do	VERB
bptjm-71	118	4	by	by	ADP
bptjm-71	118	5	targeting	target	VERB
bptjm-71	118	6	senescent	senescent	ADJ
bptjm-71	118	7	cell	cell	NOUN
bptjm-71	118	8	anti	anti	ADJ
bptjm-71	118	9	-	-	ADJ
bptjm-71	118	10	apoptotic	apoptotic	ADJ
bptjm-71	118	11	pathways	pathway	NOUN
bptjm-71	118	12	(	(	PUNCT
bptjm-71	118	13	scaps	scap	NOUN
bptjm-71	118	14	)	)	PUNCT
bptjm-71	118	15	such	such	ADJ
bptjm-71	118	16	as	as	ADP
bptjm-71	118	17	p53	p53	NOUN
bptjm-71	118	18	and	and	CCONJ
bptjm-71	118	19	bcl-2	bcl-2	NOUN
bptjm-71	118	20	.	.	PUNCT
bptjm-71	119	1	through	through	ADP
bptjm-71	119	2	removing	remove	VERB
bptjm-71	119	3	senescence	senescence	NOUN
bptjm-71	119	4	,	,	PUNCT
bptjm-71	119	5	senolytics	senolytic	NOUN
bptjm-71	119	6	have	have	VERB
bptjm-71	119	7	the	the	DET
bptjm-71	119	8	potential	potential	NOUN
bptjm-71	119	9	to	to	PART
bptjm-71	119	10	reduce	reduce	VERB
bptjm-71	119	11	neuroinflammation	neuroinflammation	NOUN
bptjm-71	119	12	,	,	PUNCT
bptjm-71	119	13	enhance	enhance	VERB
bptjm-71	119	14	tissue	tissue	NOUN
bptjm-71	119	15	regeneration	regeneration	NOUN
bptjm-71	119	16	,	,	PUNCT
bptjm-71	119	17	and	and	CCONJ
bptjm-71	119	18	improve	improve	VERB
bptjm-71	119	19	cognitive	cognitive	ADJ
bptjm-71	119	20	function	function	NOUN
bptjm-71	119	21	.	.	PUNCT
bptjm-71	120	1	the	the	DET
bptjm-71	120	2	effects	effect	NOUN
bptjm-71	120	3	of	of	ADP
bptjm-71	120	4	senolytics	senolytic	NOUN
bptjm-71	120	5	are	be	AUX
bptjm-71	120	6	currently	currently	ADV
bptjm-71	120	7	mainly	mainly	ADV
bptjm-71	120	8	tested	test	VERB
bptjm-71	120	9	through	through	ADP
bptjm-71	120	10	mouse	mouse	NOUN
bptjm-71	120	11	models	model	NOUN
bptjm-71	120	12	and	and	CCONJ
bptjm-71	120	13	cell	cell	NOUN
bptjm-71	120	14	populations	population	NOUN
bptjm-71	120	15	characterized	characterize	VERB
bptjm-71	120	16	with	with	ADP
bptjm-71	120	17	an	an	DET
bptjm-71	120	18	age	age	NOUN
bptjm-71	120	19	-	-	PUNCT
bptjm-71	120	20	related	relate	VERB
bptjm-71	120	21	disease	disease	NOUN
bptjm-71	120	22	.	.	PUNCT
bptjm-71	121	1	dasatinib	dasatinib	NOUN
bptjm-71	121	2	and	and	CCONJ
bptjm-71	121	3	quercetin	quercetin	VERB
bptjm-71	121	4	the	the	DET
bptjm-71	121	5	combination	combination	NOUN
bptjm-71	121	6	of	of	ADP
bptjm-71	121	7	dasatinib	dasatinib	NOUN
bptjm-71	121	8	and	and	CCONJ
bptjm-71	121	9	quercetin	quercetin	NOUN
bptjm-71	121	10	(	(	PUNCT
bptjm-71	121	11	d+q	d+q	NOUN
bptjm-71	121	12	)	)	PUNCT
bptjm-71	121	13	is	be	AUX
bptjm-71	121	14	one	one	NUM
bptjm-71	121	15	of	of	ADP
bptjm-71	121	16	the	the	DET
bptjm-71	121	17	most	most	ADV
bptjm-71	121	18	extensively	extensively	ADV
bptjm-71	121	19	studied	study	VERB
bptjm-71	121	20	senolytics	senolytic	NOUN
bptjm-71	121	21	,	,	PUNCT
bptjm-71	121	22	shown	show	VERB
bptjm-71	121	23	to	to	PART
bptjm-71	121	24	be	be	AUX
bptjm-71	121	25	effective	effective	ADJ
bptjm-71	121	26	in	in	ADP
bptjm-71	121	27	numerous	numerous	ADJ
bptjm-71	121	28	age	age	NOUN
bptjm-71	121	29	-	-	PUNCT
bptjm-71	121	30	related	relate	VERB
bptjm-71	121	31	diseases	disease	NOUN
bptjm-71	121	32	by	by	ADP
bptjm-71	121	33	selectively	selectively	ADV
bptjm-71	121	34	targeting	target	VERB
bptjm-71	121	35	senescent	senescent	ADJ
bptjm-71	121	36	cells	cell	NOUN
bptjm-71	121	37	while	while	SCONJ
bptjm-71	121	38	maintaining	maintain	VERB
bptjm-71	121	39	the	the	DET
bptjm-71	121	40	viability	viability	NOUN
bptjm-71	121	41	of	of	ADP
bptjm-71	121	42	non	non	ADJ
bptjm-71	121	43	-	-	ADJ
bptjm-71	121	44	senescent	senescent	ADJ
bptjm-71	121	45	cells	cell	NOUN
bptjm-71	121	46	.	.	PUNCT
bptjm-71	122	1	dasatinib	dasatinib	NOUN
bptjm-71	122	2	is	be	AUX
bptjm-71	122	3	a	a	DET
bptjm-71	122	4	tyrosine	tyrosine	NOUN
bptjm-71	122	5	kinase	kinase	NOUN
bptjm-71	122	6	inhibitor	inhibitor	NOUN
bptjm-71	122	7	that	that	PRON
bptjm-71	122	8	was	be	AUX
bptjm-71	122	9	initially	initially	ADV
bptjm-71	122	10	discovered	discover	VERB
bptjm-71	122	11	for	for	ADP
bptjm-71	122	12	use	use	NOUN
bptjm-71	122	13	in	in	ADP
bptjm-71	122	14	cancer	cancer	NOUN
bptjm-71	122	15	treatments	treatment	NOUN
bptjm-71	122	16	to	to	PART
bptjm-71	122	17	prevent	prevent	VERB
bptjm-71	122	18	cancer	cancer	NOUN
bptjm-71	122	19	cell	cell	NOUN
bptjm-71	122	20	growth	growth	NOUN
bptjm-71	122	21	.	.	PUNCT
bptjm-71	123	1	by	by	ADP
bptjm-71	123	2	targeting	target	VERB
bptjm-71	123	3	pro	pro	ADJ
bptjm-71	123	4	-	-	ADJ
bptjm-71	123	5	survival	survival	ADJ
bptjm-71	123	6	pathways	pathway	NOUN
bptjm-71	123	7	,	,	PUNCT
bptjm-71	123	8	dasatinib	dasatinib	NOUN
bptjm-71	123	9	induces	induce	VERB
bptjm-71	123	10	apoptosis	apoptosis	NOUN
bptjm-71	123	11	to	to	ADP
bptjm-71	123	12	senescent	senescent	ADJ
bptjm-71	123	13	cells	cell	NOUN
bptjm-71	123	14	.	.	PUNCT
bptjm-71	124	1	quercetin	quercetin	NOUN
bptjm-71	124	2	is	be	AUX
bptjm-71	124	3	a	a	DET
bptjm-71	124	4	natural	natural	ADJ
bptjm-71	124	5	flavonoid	flavonoid	NOUN
bptjm-71	124	6	and	and	CCONJ
bptjm-71	124	7	enhances	enhance	VERB
bptjm-71	124	8	the	the	DET
bptjm-71	124	9	effectiveness	effectiveness	NOUN
bptjm-71	124	10	of	of	ADP
bptjm-71	124	11	dasatinib	dasatinib	NOUN
bptjm-71	124	12	with	with	ADP
bptjm-71	124	13	its	its	PRON
bptjm-71	124	14	anti	anti	ADJ
bptjm-71	124	15	-	-	ADJ
bptjm-71	124	16	inflammatory	inflammatory	ADJ
bptjm-71	124	17	and	and	CCONJ
bptjm-71	124	18	pro	pro	ADJ
bptjm-71	124	19	-	-	ADJ
bptjm-71	124	20	apoptotic	apoptotic	ADJ
bptjm-71	124	21	properties	property	NOUN
bptjm-71	124	22	.	.	PUNCT
bptjm-71	125	1	when	when	SCONJ
bptjm-71	125	2	used	use	VERB
bptjm-71	125	3	together	together	ADV
bptjm-71	125	4	,	,	PUNCT
bptjm-71	125	5	their	their	PRON
bptjm-71	125	6	effectiveness	effectiveness	NOUN
bptjm-71	125	7	as	as	ADP
bptjm-71	125	8	a	a	DET
bptjm-71	125	9	senolytic	senolytic	ADJ
bptjm-71	125	10	increases	increase	NOUN
bptjm-71	125	11	,	,	PUNCT
bptjm-71	125	12	as	as	SCONJ
bptjm-71	125	13	they	they	PRON
bptjm-71	125	14	are	be	AUX
bptjm-71	125	15	able	able	ADJ
bptjm-71	125	16	to	to	PART
bptjm-71	125	17	target	target	VERB
bptjm-71	125	18	a	a	DET
bptjm-71	125	19	larger	large	ADJ
bptjm-71	125	20	variety	variety	NOUN
bptjm-71	125	21	of	of	ADP
bptjm-71	125	22	senescent	senescent	ADJ
bptjm-71	125	23	cell	cell	NOUN
bptjm-71	125	24	types	type	NOUN
bptjm-71	125	25	.	.	PUNCT
bptjm-71	126	1	beyond	beyond	ADP
bptjm-71	126	2	targeting	target	VERB
bptjm-71	126	3	scaps	scap	NOUN
bptjm-71	126	4	,	,	PUNCT
bptjm-71	126	5	quercetin	quercetin	NOUN
bptjm-71	126	6	has	have	AUX
bptjm-71	126	7	also	also	ADV
bptjm-71	126	8	been	be	AUX
bptjm-71	126	9	found	find	VERB
bptjm-71	126	10	to	to	PART
bptjm-71	126	11	improve	improve	VERB
bptjm-71	126	12	cognitive	cognitive	ADJ
bptjm-71	126	13	function	function	NOUN
bptjm-71	126	14	in	in	ADP
bptjm-71	126	15	ad	ad	NOUN
bptjm-71	126	16	patients	patient	NOUN
bptjm-71	126	17	through	through	ADP
bptjm-71	126	18	activating	activate	VERB
bptjm-71	126	19	amp	amp	NOUN
bptjm-71	126	20	-	-	PUNCT
bptjm-71	126	21	activated	activate	VERB
bptjm-71	126	22	protein	protein	NOUN
bptjm-71	126	23	kinase	kinase	NOUN
bptjm-71	126	24	leading	lead	VERB
bptjm-71	126	25	to	to	ADP
bptjm-71	126	26	a	a	DET
bptjm-71	126	27	reduction	reduction	NOUN
bptjm-71	126	28	in	in	ADP
bptjm-71	126	29	aβ	aβ	ADV
bptjm-71	126	30	-	-	PUNCT
bptjm-71	126	31	induced	induce	VERB
bptjm-71	126	32	mitochondrial	mitochondrial	ADJ
bptjm-71	126	33	dysfunction	dysfunction	NOUN
bptjm-71	126	34	,	,	PUNCT
bptjm-71	126	35	a	a	DET
bptjm-71	126	36	main	main	ADJ
bptjm-71	126	37	characteristic	characteristic	NOUN
bptjm-71	126	38	in	in	ADP
bptjm-71	126	39	early	early	ADJ
bptjm-71	126	40	ad	ad	NOUN
bptjm-71	126	41	pathogenesis.41	pathogenesis.41	NOUN
bptjm-71	126	42	through	through	ADP
bptjm-71	126	43	clearance	clearance	NOUN
bptjm-71	126	44	of	of	ADP
bptjm-71	126	45	senescent	senescent	ADJ
bptjm-71	126	46	cells	cell	NOUN
bptjm-71	126	47	by	by	ADP
bptjm-71	126	48	targeting	target	VERB
bptjm-71	126	49	bcl-2	bcl-2	NUM
bptjm-71	126	50	and	and	CCONJ
bptjm-71	126	51	other	other	ADJ
bptjm-71	126	52	anti	anti	ADJ
bptjm-71	126	53	-	-	ADJ
bptjm-71	126	54	apoptotic	apoptotic	ADJ
bptjm-71	126	55	proteins	protein	NOUN
bptjm-71	126	56	,	,	PUNCT
bptjm-71	126	57	d+q	d+q	PROPN
bptjm-71	126	58	has	have	AUX
bptjm-71	126	59	shown	show	VERB
bptjm-71	126	60	to	to	PART
bptjm-71	126	61	be	be	AUX
bptjm-71	126	62	effective	effective	ADJ
bptjm-71	126	63	in	in	ADP
bptjm-71	126	64	numerous	numerous	ADJ
bptjm-71	126	65	age	age	NOUN
bptjm-71	126	66	-	-	PUNCT
bptjm-71	126	67	related	relate	VERB
bptjm-71	126	68	conditions	condition	NOUN
bptjm-71	126	69	.	.	PUNCT
bptjm-71	127	1	by	by	ADP
bptjm-71	127	2	decreasing	decrease	VERB
bptjm-71	127	3	senescence	senescence	NOUN
bptjm-71	127	4	,	,	PUNCT
bptjm-71	127	5	d+q	d+q	PRON
bptjm-71	127	6	relieves	relieve	VERB
bptjm-71	127	7	tissue	tissue	NOUN
bptjm-71	127	8	degeneration	degeneration	NOUN
bptjm-71	127	9	,	,	PUNCT
bptjm-71	127	10	inflammation	inflammation	NOUN
bptjm-71	127	11	,	,	PUNCT
bptjm-71	127	12	and	and	CCONJ
bptjm-71	127	13	other	other	ADJ
bptjm-71	127	14	sasp	sasp	NOUN
bptjm-71	127	15	factors.42	factors.42	PROPN
bptjm-71	127	16	d+q	d+q	PROPN
bptjm-71	127	17	acts	act	VERB
bptjm-71	127	18	in	in	ADP
bptjm-71	127	19	a	a	DET
bptjm-71	127	20	dosage	dosage	NOUN
bptjm-71	127	21	-	-	PUNCT
bptjm-71	127	22	dependent	dependent	ADJ
bptjm-71	127	23	manner	manner	NOUN
bptjm-71	127	24	positively	positively	ADV
bptjm-71	127	25	correlating	correlate	VERB
bptjm-71	127	26	with	with	ADP
bptjm-71	127	27	increased	increase	VERB
bptjm-71	127	28	senescent	senescent	ADJ
bptjm-71	127	29	cell	cell	NOUN
bptjm-71	127	30	death	death	NOUN
bptjm-71	127	31	in	in	ADP
bptjm-71	127	32	mice	mouse	NOUN
bptjm-71	127	33	with	with	ADP
bptjm-71	127	34	ad	ad	NOUN
bptjm-71	127	35	,	,	PUNCT
bptjm-71	127	36	specifically	specifically	ADV
bptjm-71	127	37	in	in	ADP
bptjm-71	127	38	olgs	olgs	NOUN
bptjm-71	127	39	.	.	PUNCT
bptjm-71	128	1	these	these	DET
bptjm-71	128	2	mice	mouse	NOUN
bptjm-71	128	3	were	be	AUX
bptjm-71	128	4	also	also	ADV
bptjm-71	128	5	found	find	VERB
bptjm-71	128	6	with	with	ADP
bptjm-71	128	7	reduced	reduced	ADJ
bptjm-71	128	8	levels	level	NOUN
bptjm-71	128	9	of	of	ADP
bptjm-71	128	10	aβ	aβ	NOUN
bptjm-71	128	11	plaque	plaque	NOUN
bptjm-71	128	12	associated	associate	VERB
bptjm-71	128	13	proinflammatory	proinflammatory	ADJ
bptjm-71	128	14	cytokines	cytokine	NOUN
bptjm-71	128	15	such	such	ADJ
bptjm-71	128	16	as	as	ADP
bptjm-71	128	17	il-1β5	il-1β5	PROPN
bptjm-71	128	18	.	.	PUNCT
bptjm-71	128	19	nfts	nft	NOUN
bptjm-71	128	20	are	be	AUX
bptjm-71	128	21	also	also	ADV
bptjm-71	128	22	reduced	reduce	VERB
bptjm-71	128	23	by	by	ADP
bptjm-71	128	24	d+q	d+q	PROPN
bptjm-71	128	25	in	in	ADP
bptjm-71	128	26	tau	tau	PROPN
bptjm-71	128	27	transgenic	transgenic	NOUN
bptjm-71	128	28	mice	mouse	NOUN
bptjm-71	128	29	with	with	ADP
bptjm-71	128	30	effects	effect	NOUN
bptjm-71	128	31	of	of	ADP
bptjm-71	128	32	improved	improved	ADJ
bptjm-71	128	33	cerebral	cerebral	ADJ
bptjm-71	128	34	blood	blood	NOUN
bptjm-71	128	35	flow	flow	NOUN
bptjm-71	128	36	and	and	CCONJ
bptjm-71	128	37	berkeley	berkeley	PROPN
bptjm-71	128	38	pharma	pharma	PROPN
bptjm-71	128	39	tech	tech	NOUN
bptjm-71	128	40	journal	journal	NOUN
bptjm-71	128	41	of	of	ADP
bptjm-71	128	42	medicine	medicine	NOUN
bptjm-71	128	43	|	|	ADV
bptjm-71	128	44	56	56	NUM
bptjm-71	128	45	decreased	decrease	VERB
bptjm-71	128	46	neurodegeneration.21	neurodegeneration.21	PROPN
bptjm-71	128	47	intermittent	intermittent	ADJ
bptjm-71	128	48	treatment	treatment	NOUN
bptjm-71	128	49	with	with	ADP
bptjm-71	128	50	d+q	d+q	X
bptjm-71	128	51	on	on	ADP
bptjm-71	128	52	mice	mouse	NOUN
bptjm-71	128	53	showed	show	VERB
bptjm-71	128	54	improved	improved	ADJ
bptjm-71	128	55	cognitive	cognitive	ADJ
bptjm-71	128	56	function	function	NOUN
bptjm-71	128	57	by	by	ADP
bptjm-71	128	58	reducing	reduce	VERB
bptjm-71	128	59	senescent	senescent	ADJ
bptjm-71	128	60	microglia	microglia	NOUN
bptjm-71	128	61	.	.	PUNCT
bptjm-71	129	1	y	y	PROPN
bptjm-71	129	2	oung	oung	PROPN
bptjm-71	129	3	and	and	CCONJ
bptjm-71	129	4	aged	aged	ADJ
bptjm-71	129	5	mice	mouse	NOUN
bptjm-71	129	6	were	be	AUX
bptjm-71	129	7	put	put	VERB
bptjm-71	129	8	through	through	ADP
bptjm-71	129	9	phenotypic	phenotypic	NOUN
bptjm-71	129	10	,	,	PUNCT
bptjm-71	129	11	memory	memory	NOUN
bptjm-71	129	12	,	,	PUNCT
bptjm-71	129	13	and	and	CCONJ
bptjm-71	129	14	cognitive	cognitive	ADJ
bptjm-71	129	15	assessments	assessment	NOUN
bptjm-71	129	16	.	.	PUNCT
bptjm-71	130	1	assessment	assessment	NOUN
bptjm-71	130	2	results	result	NOUN
bptjm-71	130	3	of	of	ADP
bptjm-71	130	4	young	young	ADJ
bptjm-71	130	5	mice	mouse	NOUN
bptjm-71	130	6	were	be	AUX
bptjm-71	130	7	unchanged	unchanged	ADJ
bptjm-71	130	8	while	while	SCONJ
bptjm-71	130	9	aged	aged	ADJ
bptjm-71	130	10	mice	mouse	NOUN
bptjm-71	130	11	improved	improve	VERB
bptjm-71	130	12	significantly	significantly	ADV
bptjm-71	130	13	in	in	ADP
bptjm-71	130	14	a	a	DET
bptjm-71	130	15	stone	stone	NOUN
bptjm-71	130	16	t	t	NOUN
bptjm-71	130	17	-	-	PUNCT
bptjm-71	130	18	maze	maze	NOUN
bptjm-71	130	19	following	follow	VERB
bptjm-71	130	20	treatment	treatment	NOUN
bptjm-71	130	21	of	of	ADP
bptjm-71	130	22	d+q	d+q	ADJ
bptjm-71	130	23	suggesting	suggest	VERB
bptjm-71	130	24	high	high	ADJ
bptjm-71	130	25	effectiveness	effectiveness	NOUN
bptjm-71	130	26	of	of	ADP
bptjm-71	130	27	d+q	d+q	PROPN
bptjm-71	130	28	during	during	ADP
bptjm-71	130	29	aging.43	aging.43	PROPN
bptjm-71	130	30	a	a	DET
bptjm-71	130	31	current	current	ADJ
bptjm-71	130	32	clinical	clinical	ADJ
bptjm-71	130	33	trial	trial	NOUN
bptjm-71	130	34	of	of	ADP
bptjm-71	130	35	d+q	d+q	X
bptjm-71	130	36	involving	involve	VERB
bptjm-71	130	37	early	early	ADJ
bptjm-71	130	38	-	-	PUNCT
bptjm-71	130	39	stage	stage	NOUN
bptjm-71	130	40	older	old	ADJ
bptjm-71	130	41	ad	ad	NOUN
bptjm-71	130	42	patients	patient	NOUN
bptjm-71	130	43	suggests	suggest	VERB
bptjm-71	130	44	promising	promising	ADJ
bptjm-71	130	45	results	result	NOUN
bptjm-71	130	46	.	.	PUNCT
bptjm-71	131	1	the	the	DET
bptjm-71	131	2	patients	patient	NOUN
bptjm-71	131	3	were	be	AUX
bptjm-71	131	4	treated	treat	VERB
bptjm-71	131	5	intermittently	intermittently	ADV
bptjm-71	131	6	with	with	ADP
bptjm-71	131	7	d+q	d+q	PROPN
bptjm-71	131	8	for	for	ADP
bptjm-71	131	9	12	12	NUM
bptjm-71	131	10	weeks	week	NOUN
bptjm-71	131	11	while	while	SCONJ
bptjm-71	131	12	their	their	PRON
bptjm-71	131	13	cognitive	cognitive	ADJ
bptjm-71	131	14	function	function	NOUN
bptjm-71	131	15	and	and	CCONJ
bptjm-71	131	16	progression	progression	NOUN
bptjm-71	131	17	of	of	ADP
bptjm-71	131	18	ad	ad	NOUN
bptjm-71	131	19	were	be	AUX
bptjm-71	131	20	measured	measure	VERB
bptjm-71	131	21	.	.	PUNCT
bptjm-71	132	1	the	the	DET
bptjm-71	132	2	only	only	ADJ
bptjm-71	132	3	statistically	statistically	ADV
bptjm-71	132	4	significant	significant	ADJ
bptjm-71	132	5	changes	change	NOUN
bptjm-71	132	6	in	in	ADP
bptjm-71	132	7	safety	safety	NOUN
bptjm-71	132	8	parameters	parameter	NOUN
bptjm-71	132	9	of	of	ADP
bptjm-71	132	10	d+q	d+q	PROPN
bptjm-71	132	11	observed	observe	VERB
bptjm-71	132	12	was	be	AUX
bptjm-71	132	13	an	an	DET
bptjm-71	132	14	increase	increase	NOUN
bptjm-71	132	15	in	in	ADP
bptjm-71	132	16	total	total	ADJ
bptjm-71	132	17	cholesterol	cholesterol	NOUN
bptjm-71	132	18	,	,	PUNCT
bptjm-71	132	19	yet	yet	CCONJ
bptjm-71	132	20	this	this	DET
bptjm-71	132	21	higher	high	ADJ
bptjm-71	132	22	total	total	ADJ
bptjm-71	132	23	cholesterol	cholesterol	NOUN
bptjm-71	132	24	remained	remain	VERB
bptjm-71	132	25	in	in	ADP
bptjm-71	132	26	a	a	DET
bptjm-71	132	27	normal	normal	ADJ
bptjm-71	132	28	range	range	NOUN
bptjm-71	132	29	,	,	PUNCT
bptjm-71	132	30	and	and	CCONJ
bptjm-71	132	31	one	one	NUM
bptjm-71	132	32	possibly	possibly	ADV
bptjm-71	132	33	related	relate	VERB
bptjm-71	132	34	adverse	adverse	ADJ
bptjm-71	132	35	event	event	NOUN
bptjm-71	132	36	,	,	PUNCT
bptjm-71	132	37	yet	yet	CCONJ
bptjm-71	132	38	this	this	DET
bptjm-71	132	39	event	event	NOUN
bptjm-71	132	40	was	be	AUX
bptjm-71	132	41	resolved	resolve	VERB
bptjm-71	132	42	between	between	ADP
bptjm-71	132	43	1	1	NUM
bptjm-71	132	44	to	to	PART
bptjm-71	132	45	16	16	NUM
bptjm-71	132	46	days	day	NOUN
bptjm-71	132	47	.	.	PUNCT
bptjm-71	133	1	several	several	ADJ
bptjm-71	133	2	tests	test	NOUN
bptjm-71	133	3	were	be	AUX
bptjm-71	133	4	conducted	conduct	VERB
bptjm-71	133	5	to	to	PART
bptjm-71	133	6	test	test	VERB
bptjm-71	133	7	changes	change	NOUN
bptjm-71	133	8	in	in	ADP
bptjm-71	133	9	cognitive	cognitive	ADJ
bptjm-71	133	10	function	function	NOUN
bptjm-71	133	11	including	include	VERB
bptjm-71	133	12	the	the	DET
bptjm-71	133	13	montreal	montreal	PROPN
bptjm-71	133	14	cognitive	cognitive	ADJ
bptjm-71	133	15	assessment	assessment	NOUN
bptjm-71	133	16	(	(	PUNCT
bptjm-71	133	17	moca	moca	PROPN
bptjm-71	133	18	)	)	PUNCT
bptjm-71	133	19	and	and	CCONJ
bptjm-71	133	20	the	the	DET
bptjm-71	133	21	clinical	clinical	ADJ
bptjm-71	133	22	dementia	dementia	NOUN
bptjm-71	133	23	rating	rating	NOUN
bptjm-71	133	24	sum	sum	NOUN
bptjm-71	133	25	of	of	ADP
bptjm-71	133	26	boxes	box	NOUN
bptjm-71	133	27	(	(	PUNCT
bptjm-71	133	28	cdr	cdr	PROPN
bptjm-71	133	29	sob	sob	PROPN
bptjm-71	133	30	)	)	PUNCT
bptjm-71	133	31	.	.	PUNCT
bptjm-71	134	1	there	there	PRON
bptjm-71	134	2	was	be	VERB
bptjm-71	134	3	no	no	DET
bptjm-71	134	4	significant	significant	ADJ
bptjm-71	134	5	change	change	NOUN
bptjm-71	134	6	in	in	ADP
bptjm-71	134	7	the	the	DET
bptjm-71	134	8	results	result	NOUN
bptjm-71	134	9	from	from	ADP
bptjm-71	134	10	these	these	DET
bptjm-71	134	11	cognitive	cognitive	ADJ
bptjm-71	134	12	assessments	assessment	NOUN
bptjm-71	134	13	from	from	ADP
bptjm-71	134	14	the	the	DET
bptjm-71	134	15	baseline	baseline	NOUN
bptjm-71	134	16	to	to	ADP
bptjm-71	134	17	post	post	ADJ
bptjm-71	134	18	-	-	NOUN
bptjm-71	134	19	treatment	treatment	NOUN
bptjm-71	134	20	.	.	PUNCT
bptjm-71	135	1	mris	mris	PROPN
bptjm-71	135	2	also	also	ADV
bptjm-71	135	3	showed	show	VERB
bptjm-71	135	4	no	no	DET
bptjm-71	135	5	significant	significant	ADJ
bptjm-71	135	6	change	change	NOUN
bptjm-71	135	7	from	from	ADP
bptjm-71	135	8	the	the	DET
bptjm-71	135	9	baseline	baseline	NOUN
bptjm-71	135	10	to	to	ADP
bptjm-71	135	11	post	post	ADJ
bptjm-71	135	12	-	-	NOUN
bptjm-71	135	13	treatment	treatment	NOUN
bptjm-71	135	14	,	,	PUNCT
bptjm-71	135	15	suggesting	suggest	VERB
bptjm-71	135	16	a	a	DET
bptjm-71	135	17	stable	stable	ADJ
bptjm-71	135	18	brain	brain	NOUN
bptjm-71	135	19	morphology	morphology	NOUN
bptjm-71	135	20	over	over	ADP
bptjm-71	135	21	the	the	DET
bptjm-71	135	22	treatment	treatment	NOUN
bptjm-71	135	23	period	period	NOUN
bptjm-71	135	24	.	.	PUNCT
bptjm-71	136	1	plasma	plasma	NOUN
bptjm-71	136	2	and	and	CCONJ
bptjm-71	136	3	cerebrospinal	cerebrospinal	ADJ
bptjm-71	136	4	fluid	fluid	NOUN
bptjm-71	136	5	(	(	PUNCT
bptjm-71	136	6	csf	csf	NOUN
bptjm-71	136	7	)	)	PUNCT
bptjm-71	136	8	levels	level	NOUN
bptjm-71	136	9	revealed	reveal	VERB
bptjm-71	136	10	that	that	SCONJ
bptjm-71	136	11	d	d	PRON
bptjm-71	136	12	was	be	AUX
bptjm-71	136	13	able	able	ADJ
bptjm-71	136	14	to	to	PART
bptjm-71	136	15	penetrate	penetrate	VERB
bptjm-71	136	16	through	through	ADP
bptjm-71	136	17	the	the	DET
bptjm-71	136	18	bbb	bbb	NOUN
bptjm-71	136	19	while	while	SCONJ
bptjm-71	136	20	q	q	NOUN
bptjm-71	136	21	was	be	AUX
bptjm-71	136	22	not	not	PART
bptjm-71	136	23	able	able	ADJ
bptjm-71	136	24	to	to	PART
bptjm-71	136	25	.	.	PUNCT
bptjm-71	137	1	overall	overall	ADV
bptjm-71	137	2	,	,	PUNCT
bptjm-71	137	3	the	the	DET
bptjm-71	137	4	study	study	NOUN
bptjm-71	137	5	’s	’s	PART
bptjm-71	137	6	results	result	NOUN
bptjm-71	137	7	are	be	AUX
bptjm-71	137	8	promising	promise	VERB
bptjm-71	137	9	in	in	ADP
bptjm-71	137	10	the	the	DET
bptjm-71	137	11	safety	safety	NOUN
bptjm-71	137	12	and	and	CCONJ
bptjm-71	137	13	potential	potential	NOUN
bptjm-71	137	14	of	of	ADP
bptjm-71	137	15	d+q	d+q	PROPN
bptjm-71	137	16	as	as	ADP
bptjm-71	137	17	a	a	DET
bptjm-71	137	18	senolytic	senolytic	ADJ
bptjm-71	137	19	,	,	PUNCT
bptjm-71	137	20	yet	yet	CCONJ
bptjm-71	137	21	further	further	ADJ
bptjm-71	137	22	studies	study	NOUN
bptjm-71	137	23	are	be	AUX
bptjm-71	137	24	needed	need	VERB
bptjm-71	137	25	to	to	PART
bptjm-71	137	26	examine	examine	VERB
bptjm-71	137	27	long	long	ADJ
bptjm-71	137	28	-	-	PUNCT
bptjm-71	137	29	term	term	NOUN
bptjm-71	137	30	efficacy.44	efficacy.44	NOUN
bptjm-71	137	31	fisetin	fisetin	VERB
bptjm-71	137	32	with	with	ADP
bptjm-71	137	33	studies	study	NOUN
bptjm-71	137	34	of	of	ADP
bptjm-71	137	35	quercetin	quercetin	NOUN
bptjm-71	137	36	,	,	PUNCT
bptjm-71	137	37	a	a	DET
bptjm-71	137	38	natural	natural	ADJ
bptjm-71	137	39	flavonoid	flavonoid	NOUN
bptjm-71	137	40	,	,	PUNCT
bptjm-71	137	41	being	be	AUX
bptjm-71	137	42	an	an	DET
bptjm-71	137	43	effective	effective	ADJ
bptjm-71	137	44	senolytic	senolytic	ADJ
bptjm-71	137	45	,	,	PUNCT
bptjm-71	137	46	other	other	ADJ
bptjm-71	137	47	flavonoids	flavonoid	NOUN
bptjm-71	137	48	were	be	AUX
bptjm-71	137	49	explored	explore	VERB
bptjm-71	137	50	for	for	ADP
bptjm-71	137	51	their	their	PRON
bptjm-71	137	52	senolytic	senolytic	ADJ
bptjm-71	137	53	abilities	ability	NOUN
bptjm-71	137	54	such	such	ADJ
bptjm-71	137	55	as	as	ADP
bptjm-71	137	56	fisetin	fisetin	NOUN
bptjm-71	137	57	.	.	PUNCT
bptjm-71	137	58	fisetin	fisetin	PROPN
bptjm-71	137	59	,	,	PUNCT
bptjm-71	137	60	present	present	ADJ
bptjm-71	137	61	in	in	ADP
bptjm-71	137	62	various	various	ADJ
bptjm-71	137	63	fruits	fruit	NOUN
bptjm-71	137	64	and	and	CCONJ
bptjm-71	137	65	vegetables	vegetable	NOUN
bptjm-71	137	66	,	,	PUNCT
bptjm-71	137	67	was	be	AUX
bptjm-71	137	68	found	find	VERB
bptjm-71	137	69	to	to	PART
bptjm-71	137	70	possess	possess	VERB
bptjm-71	137	71	great	great	ADJ
bptjm-71	137	72	seno	seno	NOUN
bptjm-71	137	73	-	-	PUNCT
bptjm-71	137	74	therapeutic	therapeutic	ADJ
bptjm-71	137	75	qualities.45	qualities.45	NOUN
bptjm-71	137	76	it	it	PRON
bptjm-71	137	77	is	be	AUX
bptjm-71	137	78	assumed	assume	VERB
bptjm-71	137	79	that	that	SCONJ
bptjm-71	137	80	with	with	ADP
bptjm-71	137	81	similar	similar	ADJ
bptjm-71	137	82	chemical	chemical	NOUN
bptjm-71	137	83	structures	structure	NOUN
bptjm-71	137	84	,	,	PUNCT
bptjm-71	137	85	fisetin	fisetin	NOUN
bptjm-71	137	86	and	and	CCONJ
bptjm-71	137	87	quercetin	quercetin	NOUN
bptjm-71	137	88	hold	hold	VERB
bptjm-71	137	89	similar	similar	ADJ
bptjm-71	137	90	therapeutic	therapeutic	ADJ
bptjm-71	137	91	and	and	CCONJ
bptjm-71	137	92	anti	anti	ADJ
bptjm-71	137	93	-	-	ADJ
bptjm-71	137	94	inflammatory	inflammatory	ADJ
bptjm-71	137	95	effects.46	effects.46	NOUN
bptjm-71	137	96	with	with	ADP
bptjm-71	137	97	a	a	DET
bptjm-71	137	98	fisetin	fisetin	ADJ
bptjm-71	137	99	diet	diet	NOUN
bptjm-71	137	100	,	,	PUNCT
bptjm-71	137	101	abundance	abundance	NOUN
bptjm-71	137	102	of	of	ADP
bptjm-71	137	103	p16	p16	NOUN
bptjm-71	137	104	was	be	AUX
bptjm-71	137	105	reduced	reduce	VERB
bptjm-71	137	106	in	in	ADP
bptjm-71	137	107	aged	aged	ADJ
bptjm-71	137	108	mice	mouse	NOUN
bptjm-71	137	109	and	and	CCONJ
bptjm-71	137	110	levels	level	NOUN
bptjm-71	137	111	of	of	ADP
bptjm-71	137	112	p16	p16	NOUN
bptjm-71	137	113	and	and	CCONJ
bptjm-71	137	114	sasp	sasp	NOUN
bptjm-71	137	115	factors	factor	NOUN
bptjm-71	137	116	continued	continue	VERB
bptjm-71	137	117	to	to	PART
bptjm-71	137	118	remain	remain	VERB
bptjm-71	137	119	in	in	ADP
bptjm-71	137	120	significantly	significantly	ADV
bptjm-71	137	121	low	low	ADJ
bptjm-71	137	122	levels	level	NOUN
bptjm-71	137	123	following	follow	VERB
bptjm-71	137	124	treatment	treatment	NOUN
bptjm-71	137	125	.	.	PUNCT
bptjm-71	138	1	senescence	senescence	NOUN
bptjm-71	138	2	was	be	AUX
bptjm-71	138	3	reduced	reduce	VERB
bptjm-71	138	4	in	in	ADP
bptjm-71	138	5	multiple	multiple	ADJ
bptjm-71	138	6	organs	organ	NOUN
bptjm-71	138	7	of	of	ADP
bptjm-71	138	8	the	the	DET
bptjm-71	138	9	mice	mouse	NOUN
bptjm-71	138	10	along	along	ADP
bptjm-71	138	11	with	with	ADP
bptjm-71	138	12	markers	marker	NOUN
bptjm-71	138	13	of	of	ADP
bptjm-71	138	14	inflammation	inflammation	NOUN
bptjm-71	138	15	and	and	CCONJ
bptjm-71	138	16	oxidative	oxidative	ADJ
bptjm-71	138	17	stress.45	stress.45	NOUN
bptjm-71	138	18	through	through	ADP
bptjm-71	138	19	blocking	block	VERB
bptjm-71	138	20	mitogen	mitogen	NOUN
bptjm-71	138	21	activated	activate	VERB
bptjm-71	138	22	protein	protein	NOUN
bptjm-71	138	23	kinase	kinase	NOUN
bptjm-71	138	24	(	(	PUNCT
bptjm-71	138	25	mapk	mapk	NOUN
bptjm-71	138	26	)	)	PUNCT
bptjm-71	138	27	and	and	CCONJ
bptjm-71	138	28	nf	nf	ADJ
bptjm-71	138	29	-	-	PUNCT
bptjm-71	138	30	κb	κb	NOUN
bptjm-71	138	31	signaling	signal	VERB
bptjm-71	138	32	pathways	pathway	NOUN
bptjm-71	138	33	,	,	PUNCT
bptjm-71	138	34	fisetin	fisetin	NOUN
bptjm-71	138	35	is	be	AUX
bptjm-71	138	36	able	able	ADJ
bptjm-71	138	37	to	to	PART
bptjm-71	138	38	reduce	reduce	VERB
bptjm-71	138	39	berkeley	berkeley	PROPN
bptjm-71	138	40	pharma	pharma	PROPN
bptjm-71	138	41	tech	tech	NOUN
bptjm-71	138	42	journal	journal	NOUN
bptjm-71	138	43	of	of	ADP
bptjm-71	138	44	medicine	medicine	NOUN
bptjm-71	139	1	|	|	ADV
bptjm-71	139	2	57	57	NUM
bptjm-71	139	3	inflammation.46	inflammation.46	NOUN
bptjm-71	139	4	specifically	specifically	ADV
bptjm-71	139	5	,	,	PUNCT
bptjm-71	139	6	fisetin	fisetin	VERB
bptjm-71	139	7	targets	target	NOUN
bptjm-71	139	8	senescence	senescence	NOUN
bptjm-71	139	9	through	through	ADP
bptjm-71	139	10	the	the	DET
bptjm-71	139	11	scap	scap	NOUN
bptjm-71	139	12	networks	network	NOUN
bptjm-71	139	13	of	of	ADP
bptjm-71	139	14	bcl	bcl	PROPN
bptjm-71	139	15	-	-	PROPN
bptjm-71	139	16	xl	xl	PROPN
bptjm-71	139	17	and	and	CCONJ
bptjm-71	139	18	hif	hif	PROPN
bptjm-71	139	19	-	-	PUNCT
bptjm-71	139	20	α	α	PROPN
bptjm-71	139	21	.	.	PROPN
bptjm-71	139	22	fisetin	fisetin	PROPN
bptjm-71	139	23	has	have	AUX
bptjm-71	139	24	also	also	ADV
bptjm-71	139	25	shown	show	VERB
bptjm-71	139	26	to	to	PART
bptjm-71	139	27	be	be	AUX
bptjm-71	139	28	able	able	ADJ
bptjm-71	139	29	to	to	PART
bptjm-71	139	30	extend	extend	VERB
bptjm-71	139	31	median	median	ADJ
bptjm-71	139	32	and	and	CCONJ
bptjm-71	139	33	maximal	maximal	ADJ
bptjm-71	139	34	lifespan	lifespan	NOUN
bptjm-71	139	35	,	,	PUNCT
bptjm-71	139	36	suggesting	suggest	VERB
bptjm-71	139	37	promising	promising	ADJ
bptjm-71	139	38	results	result	NOUN
bptjm-71	139	39	for	for	ADP
bptjm-71	139	40	age	age	NOUN
bptjm-71	139	41	-	-	PUNCT
bptjm-71	139	42	related	relate	VERB
bptjm-71	139	43	treatments.47	treatments.47	NOUN
bptjm-71	139	44	fisetin	fisetin	NOUN
bptjm-71	139	45	also	also	ADV
bptjm-71	139	46	attacks	attack	VERB
bptjm-71	139	47	the	the	DET
bptjm-71	139	48	p13k	p13k	NOUN
bptjm-71	139	49	/	/	SYM
bptjm-71	139	50	akt	akt	PROPN
bptjm-71	139	51	pathway	pathway	NOUN
bptjm-71	139	52	,	,	PUNCT
bptjm-71	139	53	which	which	PRON
bptjm-71	139	54	promotes	promote	VERB
bptjm-71	139	55	cell	cell	NOUN
bptjm-71	139	56	survival	survival	NOUN
bptjm-71	139	57	,	,	PUNCT
bptjm-71	139	58	to	to	PART
bptjm-71	139	59	induce	induce	VERB
bptjm-71	139	60	apoptosis.48	apoptosis.48	ADJ
bptjm-71	139	61	human	human	ADJ
bptjm-71	139	62	adipose	adipose	NOUN
bptjm-71	139	63	tissue	tissue	NOUN
bptjm-71	139	64	explants	explant	NOUN
bptjm-71	139	65	treated	treat	VERB
bptjm-71	139	66	with	with	ADP
bptjm-71	139	67	fisetin	fisetin	NOUN
bptjm-71	139	68	had	have	VERB
bptjm-71	139	69	a	a	DET
bptjm-71	139	70	decrease	decrease	NOUN
bptjm-71	139	71	in	in	ADP
bptjm-71	139	72	sa	sa	PROPN
bptjm-71	139	73	-	-	PUNCT
bptjm-71	139	74	β	β	NOUN
bptjm-71	139	75	-	-	ADJ
bptjm-71	139	76	gal	gal	ADJ
bptjm-71	139	77	positive	positive	ADJ
bptjm-71	139	78	cells	cell	NOUN
bptjm-71	139	79	and	and	CCONJ
bptjm-71	139	80	sasp	sasp	NOUN
bptjm-71	139	81	expression	expression	NOUN
bptjm-71	139	82	of	of	ADP
bptjm-71	139	83	il-6	il-6	NOUN
bptjm-71	139	84	,	,	PUNCT
bptjm-71	139	85	il-8	il-8	NOUN
bptjm-71	139	86	,	,	PUNCT
bptjm-71	139	87	and	and	CCONJ
bptjm-71	139	88	mcp-1	mcp-1	NOUN
bptjm-71	139	89	.	.	NOUN
bptjm-71	139	90	similar	similar	ADJ
bptjm-71	139	91	to	to	ADP
bptjm-71	139	92	d+q	d+q	PROPN
bptjm-71	139	93	,	,	PUNCT
bptjm-71	139	94	fisetin	fisetin	NOUN
bptjm-71	139	95	was	be	AUX
bptjm-71	139	96	effective	effective	ADJ
bptjm-71	139	97	in	in	ADP
bptjm-71	139	98	reducing	reduce	VERB
bptjm-71	139	99	senescence	senescence	NOUN
bptjm-71	139	100	without	without	ADP
bptjm-71	139	101	affecting	affect	VERB
bptjm-71	139	102	proliferating	proliferate	VERB
bptjm-71	139	103	cells.45	cells.45	NOUN
bptjm-71	139	104	currently	currently	ADV
bptjm-71	139	105	,	,	PUNCT
bptjm-71	139	106	fisetin	fisetin	NOUN
bptjm-71	139	107	has	have	AUX
bptjm-71	139	108	proven	prove	VERB
bptjm-71	139	109	to	to	PART
bptjm-71	139	110	be	be	AUX
bptjm-71	139	111	successful	successful	ADJ
bptjm-71	139	112	as	as	ADP
bptjm-71	139	113	a	a	DET
bptjm-71	139	114	senotherapeutic	senotherapeutic	ADJ
bptjm-71	139	115	agent	agent	NOUN
bptjm-71	139	116	,	,	PUNCT
bptjm-71	139	117	yet	yet	CCONJ
bptjm-71	139	118	further	further	ADJ
bptjm-71	139	119	testing	testing	NOUN
bptjm-71	139	120	is	be	AUX
bptjm-71	139	121	needed	need	VERB
bptjm-71	139	122	to	to	PART
bptjm-71	139	123	study	study	VERB
bptjm-71	139	124	its	its	PRON
bptjm-71	139	125	safety	safety	NOUN
bptjm-71	139	126	for	for	ADP
bptjm-71	139	127	age	age	NOUN
bptjm-71	139	128	-	-	PUNCT
bptjm-71	139	129	related	relate	VERB
bptjm-71	139	130	and	and	CCONJ
bptjm-71	139	131	neurodegenerative	neurodegenerative	ADJ
bptjm-71	139	132	treatments.47	treatments.47	PROPN
bptjm-71	139	133	navitoclax	navitoclax	PROPN
bptjm-71	139	134	navitoclax	navitoclax	PROPN
bptjm-71	139	135	,	,	PUNCT
bptjm-71	139	136	also	also	ADV
bptjm-71	139	137	known	know	VERB
bptjm-71	139	138	as	as	ADP
bptjm-71	139	139	abt263	abt263	PROPN
bptjm-71	139	140	,	,	PUNCT
bptjm-71	139	141	is	be	AUX
bptjm-71	139	142	another	another	DET
bptjm-71	139	143	discovered	discover	VERB
bptjm-71	139	144	senolytic	senolytic	ADJ
bptjm-71	139	145	.	.	PUNCT
bptjm-71	140	1	initially	initially	ADV
bptjm-71	140	2	used	use	VERB
bptjm-71	140	3	as	as	ADP
bptjm-71	140	4	an	an	DET
bptjm-71	140	5	anti	anti	ADJ
bptjm-71	140	6	-	-	ADJ
bptjm-71	140	7	cancer	cancer	ADJ
bptjm-71	140	8	drug	drug	NOUN
bptjm-71	140	9	,	,	PUNCT
bptjm-71	140	10	navitoclax	navitoclax	PROPN
bptjm-71	140	11	works	work	VERB
bptjm-71	140	12	by	by	ADP
bptjm-71	140	13	inducing	induce	VERB
bptjm-71	140	14	apoptosis	apoptosis	NOUN
bptjm-71	140	15	in	in	ADP
bptjm-71	140	16	cancer	cancer	NOUN
bptjm-71	140	17	cells	cell	NOUN
bptjm-71	140	18	.	.	PUNCT
bptjm-71	141	1	this	this	DET
bptjm-71	141	2	mechanism	mechanism	NOUN
bptjm-71	141	3	is	be	AUX
bptjm-71	141	4	likewise	likewise	ADV
bptjm-71	141	5	in	in	ADP
bptjm-71	141	6	its	its	PRON
bptjm-71	141	7	role	role	NOUN
bptjm-71	141	8	as	as	ADP
bptjm-71	141	9	a	a	DET
bptjm-71	141	10	senolytic	senolytic	ADJ
bptjm-71	141	11	drug	drug	NOUN
bptjm-71	141	12	,	,	PUNCT
bptjm-71	141	13	disrupting	disrupt	VERB
bptjm-71	141	14	bcl-2	bcl-2	ADJ
bptjm-71	141	15	and	and	CCONJ
bptjm-71	141	16	pro	pro	ADJ
bptjm-71	141	17	-	-	ADJ
bptjm-71	141	18	death	death	ADJ
bptjm-71	141	19	proteins	protein	NOUN
bptjm-71	141	20	to	to	PART
bptjm-71	141	21	induce	induce	VERB
bptjm-71	141	22	apoptosis	apoptosis	NOUN
bptjm-71	141	23	in	in	ADP
bptjm-71	141	24	senescent	senescent	ADJ
bptjm-71	141	25	cells.49	cells.49	NOUN
bptjm-71	141	26	this	this	DET
bptjm-71	141	27	disruption	disruption	NOUN
bptjm-71	141	28	is	be	AUX
bptjm-71	141	29	caused	cause	VERB
bptjm-71	141	30	by	by	ADP
bptjm-71	141	31	navitoclax	navitoclax	ADJ
bptjm-71	141	32	binding	bind	VERB
bptjm-71	141	33	to	to	ADP
bptjm-71	141	34	bh3	bh3	PROPN
bptjm-71	141	35	of	of	ADP
bptjm-71	141	36	bcl-2	bcl-2	NOUN
bptjm-71	141	37	,	,	PUNCT
bptjm-71	141	38	resulting	result	VERB
bptjm-71	141	39	in	in	ADP
bptjm-71	141	40	the	the	DET
bptjm-71	141	41	displacement	displacement	NOUN
bptjm-71	141	42	of	of	ADP
bptjm-71	141	43	a	a	DET
bptjm-71	141	44	pro	pro	ADJ
bptjm-71	141	45	-	-	ADJ
bptjm-71	141	46	apoptotic	apoptotic	ADJ
bptjm-71	141	47	protein	protein	NOUN
bptjm-71	141	48	,	,	PUNCT
bptjm-71	141	49	bim	bim	NOUN
bptjm-71	141	50	,	,	PUNCT
bptjm-71	141	51	that	that	PRON
bptjm-71	141	52	causes	cause	VERB
bptjm-71	141	53	cell	cell	NOUN
bptjm-71	141	54	apoptosis	apoptosis	NOUN
bptjm-71	141	55	(	(	PUNCT
bptjm-71	141	56	fig	fig	NOUN
bptjm-71	141	57	.	.	PUNCT
bptjm-71	142	1	4).50	4).50	NUM
bptjm-71	142	2	aged	aged	ADJ
bptjm-71	142	3	mice	mouse	NOUN
bptjm-71	142	4	treated	treat	VERB
bptjm-71	142	5	with	with	ADP
bptjm-71	142	6	navitoclax	navitoclax	ADJ
bptjm-71	142	7	enhanced	enhance	VERB
bptjm-71	142	8	neurovascular	neurovascular	ADJ
bptjm-71	142	9	coupling	coupling	NOUN
bptjm-71	142	10	,	,	PUNCT
bptjm-71	142	11	regulating	regulate	VERB
bptjm-71	142	12	cerebral	cerebral	ADJ
bptjm-71	142	13	blood	blood	NOUN
bptjm-71	142	14	flow	flow	NOUN
bptjm-71	142	15	that	that	PRON
bptjm-71	142	16	is	be	AUX
bptjm-71	142	17	essential	essential	ADJ
bptjm-71	142	18	for	for	ADP
bptjm-71	142	19	cognitive	cognitive	ADJ
bptjm-71	142	20	function	function	NOUN
bptjm-71	142	21	.	.	PUNCT
bptjm-71	143	1	examination	examination	NOUN
bptjm-71	143	2	through	through	ADP
bptjm-71	143	3	a	a	DET
bptjm-71	143	4	radial	radial	ADJ
bptjm-71	143	5	arms	arm	NOUN
bptjm-71	143	6	water	water	NOUN
bptjm-71	143	7	maze	maze	NOUN
bptjm-71	143	8	,	,	PUNCT
bptjm-71	143	9	navitoclax	navitoclax	INTJ
bptjm-71	143	10	improved	improve	VERB
bptjm-71	143	11	on	on	ADP
bptjm-71	143	12	the	the	DET
bptjm-71	143	13	learning	learn	VERB
bptjm-71	143	14	capabilities	capability	NOUN
bptjm-71	143	15	and	and	CCONJ
bptjm-71	143	16	memory	memory	NOUN
bptjm-71	143	17	retention	retention	NOUN
bptjm-71	143	18	in	in	ADP
bptjm-71	143	19	aged	aged	ADJ
bptjm-71	143	20	mice.51	mice.51	NOUN
bptjm-71	143	21	hippocampal	hippocampal	ADJ
bptjm-71	143	22	neurogenesis	neurogenesis	NOUN
bptjm-71	143	23	reduced	reduce	VERB
bptjm-71	143	24	by	by	ADP
bptjm-71	143	25	aging	age	VERB
bptjm-71	143	26	can	can	AUX
bptjm-71	143	27	be	be	AUX
bptjm-71	143	28	restored	restore	VERB
bptjm-71	143	29	by	by	ADP
bptjm-71	143	30	navitoclax	navitoclax	PROPN
bptjm-71	143	31	.	.	PUNCT
bptjm-71	144	1	by	by	ADP
bptjm-71	144	2	targeting	target	VERB
bptjm-71	144	3	senescent	senescent	ADJ
bptjm-71	144	4	cells	cell	NOUN
bptjm-71	144	5	that	that	PRON
bptjm-71	144	6	impair	impair	VERB
bptjm-71	144	7	neural	neural	ADJ
bptjm-71	144	8	progenitor	progenitor	NOUN
bptjm-71	144	9	cells	cell	NOUN
bptjm-71	144	10	(	(	PUNCT
bptjm-71	144	11	npcs	npc	NOUN
bptjm-71	144	12	)	)	PUNCT
bptjm-71	144	13	,	,	PUNCT
bptjm-71	144	14	hippocampal	hippocampal	ADJ
bptjm-71	144	15	neurons	neuron	NOUN
bptjm-71	144	16	and	and	CCONJ
bptjm-71	144	17	hippocampus	hippocampus	NOUN
bptjm-71	144	18	-	-	PUNCT
bptjm-71	144	19	dependent	dependent	ADJ
bptjm-71	144	20	spatial	spatial	ADJ
bptjm-71	144	21	memory	memory	NOUN
bptjm-71	144	22	function	function	NOUN
bptjm-71	144	23	was	be	AUX
bptjm-71	144	24	increased	increase	VERB
bptjm-71	144	25	following	follow	VERB
bptjm-71	144	26	navitoclax	navitoclax	ADJ
bptjm-71	144	27	treatment.52	treatment.52	NOUN
bptjm-71	144	28	trails	trail	NOUN
bptjm-71	144	29	of	of	ADP
bptjm-71	144	30	navitoclax	navitoclax	ADJ
bptjm-71	144	31	were	be	AUX
bptjm-71	144	32	tested	test	VERB
bptjm-71	144	33	on	on	ADP
bptjm-71	144	34	p16	p16	NOUN
bptjm-71	144	35	transgenic	transgenic	NOUN
bptjm-71	144	36	mice	mouse	NOUN
bptjm-71	144	37	in	in	ADP
bptjm-71	144	38	biweekly	biweekly	ADJ
bptjm-71	144	39	cycles	cycle	NOUN
bptjm-71	144	40	.	.	PUNCT
bptjm-71	145	1	apoptosis	apoptosis	NOUN
bptjm-71	145	2	of	of	ADP
bptjm-71	145	3	senescent	senescent	ADJ
bptjm-71	145	4	cells	cell	NOUN
bptjm-71	145	5	increased	increase	VERB
bptjm-71	145	6	in	in	ADP
bptjm-71	145	7	these	these	DET
bptjm-71	145	8	mice	mouse	NOUN
bptjm-71	145	9	,	,	PUNCT
bptjm-71	145	10	yet	yet	CCONJ
bptjm-71	145	11	the	the	DET
bptjm-71	145	12	possibility	possibility	NOUN
bptjm-71	145	13	of	of	ADP
bptjm-71	145	14	thrombocytopenia	thrombocytopenia	NOUN
bptjm-71	145	15	and	and	CCONJ
bptjm-71	145	16	neutropenia	neutropenia	NOUN
bptjm-71	145	17	as	as	ADP
bptjm-71	145	18	side	side	NOUN
bptjm-71	145	19	effects	effect	NOUN
bptjm-71	145	20	rose.48	rose.48	PROPN
bptjm-71	145	21	berkeley	berkeley	PROPN
bptjm-71	145	22	pharma	pharma	PROPN
bptjm-71	145	23	tech	tech	NOUN
bptjm-71	145	24	journal	journal	NOUN
bptjm-71	145	25	of	of	ADP
bptjm-71	145	26	medicine	medicine	NOUN
bptjm-71	145	27	|	|	ADV
bptjm-71	145	28	58	58	NUM
bptjm-71	145	29	figure	figure	NOUN
bptjm-71	145	30	4	4	NUM
bptjm-71	145	31	:	:	PUNCT
bptjm-71	145	32	navitoclax	navitoclax	ADJ
bptjm-71	145	33	mechanism	mechanism	NOUN
bptjm-71	145	34	of	of	ADP
bptjm-71	145	35	action	action	NOUN
bptjm-71	145	36	in	in	ADP
bptjm-71	145	37	senescence	senescence	NOUN
bptjm-71	145	38	.	.	PUNCT
bptjm-71	146	1	the	the	DET
bptjm-71	146	2	figure	figure	NOUN
bptjm-71	146	3	demonstrates	demonstrate	VERB
bptjm-71	146	4	navitoclax	navitoclax	ADV
bptjm-71	146	5	targeting	target	VERB
bptjm-71	146	6	the	the	DET
bptjm-71	146	7	bcl-2	bcl-2	PUNCT
bptjm-71	146	8	pathway	pathway	NOUN
bptjm-71	146	9	to	to	PART
bptjm-71	146	10	release	release	VERB
bptjm-71	146	11	caspase	caspase	NOUN
bptjm-71	146	12	3	3	NUM
bptjm-71	146	13	and	and	CCONJ
bptjm-71	146	14	cause	cause	VERB
bptjm-71	146	15	apoptosis	apoptosis	NOUN
bptjm-71	146	16	in	in	ADP
bptjm-71	146	17	senescence	senescence	NOUN
bptjm-71	146	18	.	.	PUNCT
bptjm-71	147	1	ap-20187	ap-20187	PROPN
bptjm-71	147	2	ap-20187	ap-20187	PROPN
bptjm-71	147	3	(	(	PUNCT
bptjm-71	147	4	ap	ap	PROPN
bptjm-71	147	5	)	)	PUNCT
bptjm-71	147	6	is	be	AUX
bptjm-71	147	7	a	a	DET
bptjm-71	147	8	drug	drug	NOUN
bptjm-71	147	9	that	that	PRON
bptjm-71	147	10	targets	target	VERB
bptjm-71	147	11	senescence	senescence	NOUN
bptjm-71	147	12	by	by	ADP
bptjm-71	147	13	disrupting	disrupt	VERB
bptjm-71	147	14	scaps	scap	NOUN
bptjm-71	147	15	and	and	CCONJ
bptjm-71	147	16	activating	activate	VERB
bptjm-71	147	17	a	a	DET
bptjm-71	147	18	pro	pro	ADJ
bptjm-71	147	19	-	-	ADJ
bptjm-71	147	20	apoptosis	apoptosis	ADJ
bptjm-71	147	21	protein.53	protein.53	NOUN
bptjm-71	147	22	a	a	DET
bptjm-71	147	23	study	study	NOUN
bptjm-71	147	24	on	on	ADP
bptjm-71	147	25	young	young	ADJ
bptjm-71	147	26	and	and	CCONJ
bptjm-71	147	27	old	old	ADJ
bptjm-71	147	28	ink	ink	NOUN
bptjm-71	147	29	-	-	PUNCT
bptjm-71	147	30	a	a	DET
bptjm-71	147	31	ttac	ttac	ADJ
bptjm-71	147	32	mice	mouse	NOUN
bptjm-71	147	33	revealed	reveal	VERB
bptjm-71	147	34	significant	significant	ADJ
bptjm-71	147	35	effectiveness	effectiveness	NOUN
bptjm-71	147	36	in	in	ADP
bptjm-71	147	37	clearing	clear	VERB
bptjm-71	147	38	senescence	senescence	NOUN
bptjm-71	147	39	during	during	ADP
bptjm-71	147	40	aging	age	VERB
bptjm-71	147	41	following	follow	VERB
bptjm-71	147	42	intermittent	intermittent	ADJ
bptjm-71	147	43	treatment	treatment	NOUN
bptjm-71	147	44	of	of	ADP
bptjm-71	147	45	ap	ap	PROPN
bptjm-71	147	46	.	.	PUNCT
bptjm-71	148	1	cognitive	cognitive	ADJ
bptjm-71	148	2	impairment	impairment	NOUN
bptjm-71	148	3	was	be	AUX
bptjm-71	148	4	reduced	reduce	VERB
bptjm-71	148	5	without	without	ADP
bptjm-71	148	6	affecting	affect	VERB
bptjm-71	148	7	the	the	DET
bptjm-71	148	8	physicality	physicality	NOUN
bptjm-71	148	9	of	of	ADP
bptjm-71	148	10	the	the	DET
bptjm-71	148	11	mice	mouse	NOUN
bptjm-71	148	12	.	.	PUNCT
bptjm-71	149	1	specifically	specifically	ADV
bptjm-71	149	2	,	,	PUNCT
bptjm-71	149	3	aging	age	VERB
bptjm-71	149	4	-	-	PUNCT
bptjm-71	149	5	induced	induced	ADJ
bptjm-71	149	6	senescent	senescent	ADJ
bptjm-71	149	7	microglia	microglia	NOUN
bptjm-71	149	8	was	be	AUX
bptjm-71	149	9	reduced	reduce	VERB
bptjm-71	149	10	in	in	ADP
bptjm-71	149	11	aged	aged	ADJ
bptjm-71	149	12	mice	mouse	NOUN
bptjm-71	149	13	with	with	ADP
bptjm-71	149	14	ap	ap	PROPN
bptjm-71	149	15	treatment.43	treatment.43	PROPN
bptjm-71	149	16	in	in	ADP
bptjm-71	149	17	another	another	DET
bptjm-71	149	18	study	study	NOUN
bptjm-71	149	19	,	,	PUNCT
bptjm-71	149	20	ap	ap	PROPN
bptjm-71	149	21	increased	increase	VERB
bptjm-71	149	22	neuron	neuron	PROPN
bptjm-71	149	23	density	density	NOUN
bptjm-71	149	24	and	and	CCONJ
bptjm-71	149	25	decreased	decrease	VERB
bptjm-71	149	26	tau	tau	PROPN
bptjm-71	149	27	aggregation	aggregation	NOUN
bptjm-71	149	28	in	in	ADP
bptjm-71	149	29	ps19	ps19	PROPN
bptjm-71	149	30	mice	mouse	NOUN
bptjm-71	149	31	,	,	PUNCT
bptjm-71	149	32	which	which	PRON
bptjm-71	149	33	express	express	VERB
bptjm-71	149	34	models	model	NOUN
bptjm-71	149	35	of	of	ADP
bptjm-71	149	36	tauopathy	tauopathy	NOUN
bptjm-71	149	37	,	,	PUNCT
bptjm-71	149	38	with	with	ADP
bptjm-71	149	39	twice	twice	ADV
bptjm-71	149	40	-	-	PUNCT
bptjm-71	149	41	weekly	weekly	NOUN
bptjm-71	149	42	administrations	administration	NOUN
bptjm-71	149	43	.	.	PUNCT
bptjm-71	150	1	with	with	ADP
bptjm-71	150	2	treatment	treatment	NOUN
bptjm-71	150	3	,	,	PUNCT
bptjm-71	150	4	expression	expression	NOUN
bptjm-71	150	5	of	of	ADP
bptjm-71	150	6	senescent	senescent	ADJ
bptjm-71	150	7	genes	gene	NOUN
bptjm-71	150	8	were	be	AUX
bptjm-71	150	9	measured	measure	VERB
bptjm-71	150	10	at	at	ADP
bptjm-71	150	11	levels	level	NOUN
bptjm-71	150	12	compared	compare	VERB
bptjm-71	150	13	to	to	ADP
bptjm-71	150	14	that	that	PRON
bptjm-71	150	15	of	of	ADP
bptjm-71	150	16	control	control	NOUN
bptjm-71	150	17	mice	mouse	NOUN
bptjm-71	150	18	.	.	PUNCT
bptjm-71	151	1	treatment	treatment	NOUN
bptjm-71	151	2	of	of	ADP
bptjm-71	151	3	ap	ap	PROPN
bptjm-71	151	4	was	be	AUX
bptjm-71	151	5	able	able	ADJ
bptjm-71	151	6	to	to	PART
bptjm-71	151	7	mitigate	mitigate	VERB
bptjm-71	151	8	short	short	ADJ
bptjm-71	151	9	-	-	PUNCT
bptjm-71	151	10	term	term	NOUN
bptjm-71	151	11	memory	memory	NOUN
bptjm-71	151	12	loss	loss	NOUN
bptjm-71	151	13	in	in	ADP
bptjm-71	151	14	novel	novel	NOUN
bptjm-71	151	15	-	-	PUNCT
bptjm-71	151	16	scent	scent	NOUN
bptjm-71	151	17	discrimination	discrimination	NOUN
bptjm-71	151	18	assessments.20	assessments.20	PROPN
bptjm-71	151	19	berkeley	berkeley	PROPN
bptjm-71	151	20	pharma	pharma	PROPN
bptjm-71	151	21	tech	tech	NOUN
bptjm-71	151	22	journal	journal	NOUN
bptjm-71	151	23	of	of	ADP
bptjm-71	151	24	medicine	medicine	NOUN
bptjm-71	151	25	|	|	ADV
bptjm-71	151	26	59	59	NUM
bptjm-71	151	27	limitations	limitation	NOUN
bptjm-71	151	28	senolytics	senolytic	NOUN
bptjm-71	151	29	is	be	AUX
bptjm-71	151	30	an	an	DET
bptjm-71	151	31	emerging	emerge	VERB
bptjm-71	151	32	field	field	NOUN
bptjm-71	151	33	and	and	CCONJ
bptjm-71	151	34	therefore	therefore	ADV
bptjm-71	151	35	there	there	PRON
bptjm-71	151	36	remains	remain	VERB
bptjm-71	151	37	a	a	DET
bptjm-71	151	38	lack	lack	NOUN
bptjm-71	151	39	of	of	ADP
bptjm-71	151	40	information	information	NOUN
bptjm-71	151	41	on	on	ADP
bptjm-71	151	42	the	the	DET
bptjm-71	151	43	exact	exact	ADJ
bptjm-71	151	44	mechanisms	mechanism	NOUN
bptjm-71	151	45	of	of	ADP
bptjm-71	151	46	senolytics	senolytic	NOUN
bptjm-71	151	47	in	in	ADP
bptjm-71	151	48	neurodegenerative	neurodegenerative	ADJ
bptjm-71	151	49	diseases	disease	NOUN
bptjm-71	151	50	and	and	CCONJ
bptjm-71	151	51	long	long	ADJ
bptjm-71	151	52	-	-	PUNCT
bptjm-71	151	53	term	term	NOUN
bptjm-71	151	54	effects	effect	NOUN
bptjm-71	151	55	.	.	PUNCT
bptjm-71	152	1	future	future	ADJ
bptjm-71	152	2	studies	study	NOUN
bptjm-71	152	3	are	be	AUX
bptjm-71	152	4	necessary	necessary	ADJ
bptjm-71	152	5	to	to	PART
bptjm-71	152	6	test	test	VERB
bptjm-71	152	7	the	the	DET
bptjm-71	152	8	safety	safety	NOUN
bptjm-71	152	9	and	and	CCONJ
bptjm-71	152	10	efficacy	efficacy	NOUN
bptjm-71	152	11	of	of	ADP
bptjm-71	152	12	senolytics	senolytic	NOUN
bptjm-71	152	13	long	long	ADJ
bptjm-71	152	14	-	-	PUNCT
bptjm-71	152	15	term	term	NOUN
bptjm-71	152	16	before	before	ADP
bptjm-71	152	17	being	be	AUX
bptjm-71	152	18	able	able	ADJ
bptjm-71	152	19	to	to	PART
bptjm-71	152	20	be	be	AUX
bptjm-71	152	21	used	use	VERB
bptjm-71	152	22	beyond	beyond	ADP
bptjm-71	152	23	clinical	clinical	ADJ
bptjm-71	152	24	trials.54	trials.54	NOUN
bptjm-71	152	25	while	while	SCONJ
bptjm-71	152	26	senolytics	senolytic	NOUN
bptjm-71	152	27	have	have	AUX
bptjm-71	152	28	shown	show	VERB
bptjm-71	152	29	to	to	PART
bptjm-71	152	30	improve	improve	VERB
bptjm-71	152	31	lifespan	lifespan	NOUN
bptjm-71	152	32	,	,	PUNCT
bptjm-71	152	33	cognitive	cognitive	ADJ
bptjm-71	152	34	functions	function	NOUN
bptjm-71	152	35	,	,	PUNCT
bptjm-71	152	36	and	and	CCONJ
bptjm-71	152	37	anti	anti	ADJ
bptjm-71	152	38	-	-	ADJ
bptjm-71	152	39	inflammation	inflammation	ADJ
bptjm-71	152	40	,	,	PUNCT
bptjm-71	152	41	senolytics	senolytic	NOUN
bptjm-71	152	42	have	have	VERB
bptjm-71	152	43	the	the	DET
bptjm-71	152	44	risk	risk	NOUN
bptjm-71	152	45	of	of	ADP
bptjm-71	152	46	eliminating	eliminate	VERB
bptjm-71	152	47	benefits	benefit	NOUN
bptjm-71	152	48	of	of	ADP
bptjm-71	152	49	senescence	senescence	NOUN
bptjm-71	152	50	such	such	ADJ
bptjm-71	152	51	as	as	ADP
bptjm-71	152	52	wound	wound	NOUN
bptjm-71	152	53	healing	healing	NOUN
bptjm-71	152	54	and	and	CCONJ
bptjm-71	152	55	tissue	tissue	NOUN
bptjm-71	152	56	development	development	NOUN
bptjm-71	152	57	.	.	PUNCT
bptjm-71	153	1	since	since	SCONJ
bptjm-71	153	2	senescent	senescent	ADJ
bptjm-71	153	3	cells	cell	NOUN
bptjm-71	153	4	are	be	AUX
bptjm-71	153	5	not	not	PART
bptjm-71	153	6	replaced	replace	VERB
bptjm-71	153	7	when	when	SCONJ
bptjm-71	153	8	removed	remove	VERB
bptjm-71	153	9	by	by	ADP
bptjm-71	153	10	senolytics	senolytic	NOUN
bptjm-71	153	11	,	,	PUNCT
bptjm-71	153	12	fibrosis	fibrosis	NOUN
bptjm-71	153	13	can	can	AUX
bptjm-71	153	14	occur	occur	VERB
bptjm-71	153	15	,	,	PUNCT
bptjm-71	153	16	resulting	result	VERB
bptjm-71	153	17	in	in	ADP
bptjm-71	153	18	scarring	scarring	NOUN
bptjm-71	153	19	and	and	CCONJ
bptjm-71	153	20	thickening	thickening	NOUN
bptjm-71	153	21	of	of	ADP
bptjm-71	153	22	tissues.55	tissues.55	PROPN
bptjm-71	153	23	as	as	SCONJ
bptjm-71	153	24	there	there	PRON
bptjm-71	153	25	are	be	VERB
bptjm-71	153	26	other	other	ADJ
bptjm-71	153	27	cell	cell	NOUN
bptjm-71	153	28	types	type	NOUN
bptjm-71	153	29	that	that	PRON
bptjm-71	153	30	are	be	AUX
bptjm-71	153	31	non	non	ADJ
bptjm-71	153	32	-	-	ADJ
bptjm-71	153	33	senescent	senescent	ADJ
bptjm-71	153	34	yet	yet	ADV
bptjm-71	153	35	can	can	AUX
bptjm-71	153	36	have	have	VERB
bptjm-71	153	37	a	a	DET
bptjm-71	153	38	high	high	ADJ
bptjm-71	153	39	p16	p16	NOUN
bptjm-71	153	40	expression	expression	NOUN
bptjm-71	153	41	,	,	PUNCT
bptjm-71	153	42	some	some	DET
bptjm-71	153	43	senolytics	senolytic	NOUN
bptjm-71	153	44	such	such	ADJ
bptjm-71	153	45	as	as	ADP
bptjm-71	153	46	navitoclax	navitoclax	ADJ
bptjm-71	153	47	and	and	CCONJ
bptjm-71	153	48	ap	ap	PROPN
bptjm-71	153	49	can	can	AUX
bptjm-71	153	50	have	have	VERB
bptjm-71	153	51	off	off	ADP
bptjm-71	153	52	-	-	PUNCT
bptjm-71	153	53	target	target	NOUN
bptjm-71	153	54	effects	effect	NOUN
bptjm-71	153	55	and	and	CCONJ
bptjm-71	153	56	eliminate	eliminate	VERB
bptjm-71	153	57	non	non	ADJ
bptjm-71	153	58	-	-	ADJ
bptjm-71	153	59	senescent	senescent	ADJ
bptjm-71	153	60	cells.43,56	cells.43,56	NOUN
bptjm-71	153	61	3.2	3.2	NUM
bptjm-71	153	62	.	.	PUNCT
bptjm-71	154	1	senomorphics	senomorphic	NOUN
bptjm-71	154	2	senomorphic	senomorphic	ADJ
bptjm-71	154	3	medications	medication	NOUN
bptjm-71	154	4	intervene	intervene	VERB
bptjm-71	154	5	with	with	ADP
bptjm-71	154	6	sasp	sasp	NOUN
bptjm-71	154	7	factors	factor	NOUN
bptjm-71	154	8	without	without	ADP
bptjm-71	154	9	inducing	induce	VERB
bptjm-71	154	10	apoptosis	apoptosis	NOUN
bptjm-71	154	11	.	.	PUNCT
bptjm-71	155	1	unlike	unlike	ADP
bptjm-71	155	2	senolytics	senolytic	NOUN
bptjm-71	155	3	,	,	PUNCT
bptjm-71	155	4	the	the	DET
bptjm-71	155	5	benefit	benefit	NOUN
bptjm-71	155	6	of	of	ADP
bptjm-71	155	7	senomorphic	senomorphic	ADJ
bptjm-71	155	8	drugs	drug	NOUN
bptjm-71	155	9	is	be	AUX
bptjm-71	155	10	that	that	SCONJ
bptjm-71	155	11	they	they	PRON
bptjm-71	155	12	do	do	AUX
bptjm-71	155	13	not	not	PART
bptjm-71	155	14	kill	kill	VERB
bptjm-71	155	15	functioning	function	VERB
bptjm-71	155	16	senescent	senescent	ADJ
bptjm-71	155	17	cells	cell	NOUN
bptjm-71	155	18	,	,	PUNCT
bptjm-71	155	19	which	which	PRON
bptjm-71	155	20	are	be	AUX
bptjm-71	155	21	still	still	ADV
bptjm-71	155	22	important	important	ADJ
bptjm-71	155	23	for	for	ADP
bptjm-71	155	24	anti	anti	ADJ
bptjm-71	155	25	-	-	ADJ
bptjm-71	155	26	tumor	tumor	ADJ
bptjm-71	155	27	cell	cell	NOUN
bptjm-71	155	28	signaling	signal	VERB
bptjm-71	155	29	(	(	PUNCT
bptjm-71	155	30	fig	fig	NOUN
bptjm-71	155	31	.	.	PUNCT
bptjm-71	155	32	5	5	NUM
bptjm-71	155	33	)	)	PUNCT
bptjm-71	155	34	.	.	PUNCT
bptjm-71	156	1	senomorphic	senomorphic	ADJ
bptjm-71	156	2	medication	medication	NOUN
bptjm-71	156	3	mainly	mainly	ADV
bptjm-71	156	4	targets	target	VERB
bptjm-71	156	5	signaling	signal	VERB
bptjm-71	156	6	pathways	pathway	NOUN
bptjm-71	156	7	:	:	PUNCT
bptjm-71	156	8	nf	nf	NUM
bptjm-71	156	9	-	-	PUNCT
bptjm-71	156	10	κb	κb	PROPN
bptjm-71	156	11	,	,	PUNCT
bptjm-71	156	12	mtor	mtor	NOUN
bptjm-71	156	13	,	,	PUNCT
bptjm-71	156	14	il-1α	il-1α	PROPN
bptjm-71	156	15	,	,	PUNCT
bptjm-71	156	16	p38	p38	NOUN
bptjm-71	156	17	mapk	mapk	NOUN
bptjm-71	156	18	,	,	PUNCT
bptjm-71	156	19	etc	etc	X
bptjm-71	156	20	.	.	X
bptjm-71	157	1	there	there	PRON
bptjm-71	157	2	are	be	VERB
bptjm-71	157	3	currently	currently	ADV
bptjm-71	157	4	multiple	multiple	ADJ
bptjm-71	157	5	senomorphic	senomorphic	ADJ
bptjm-71	157	6	drugs	drug	NOUN
bptjm-71	157	7	being	be	AUX
bptjm-71	157	8	tested	test	VERB
bptjm-71	157	9	to	to	ADP
bptjm-71	157	10	varying	vary	VERB
bptjm-71	157	11	levels	level	NOUN
bptjm-71	157	12	of	of	ADP
bptjm-71	157	13	success	success	NOUN
bptjm-71	157	14	that	that	PRON
bptjm-71	157	15	will	will	AUX
bptjm-71	157	16	be	be	AUX
bptjm-71	157	17	covered	cover	VERB
bptjm-71	157	18	in	in	ADP
bptjm-71	157	19	the	the	DET
bptjm-71	157	20	following	follow	VERB
bptjm-71	157	21	sections	section	NOUN
bptjm-71	157	22	.	.	PUNCT
bptjm-71	158	1	berkeley	berkeley	PROPN
bptjm-71	158	2	pharma	pharma	PROPN
bptjm-71	158	3	tech	tech	PROPN
bptjm-71	158	4	journal	journal	NOUN
bptjm-71	158	5	of	of	ADP
bptjm-71	158	6	medicine	medicine	NOUN
bptjm-71	158	7	|	|	ADV
bptjm-71	158	8	60	60	NUM
bptjm-71	158	9	figure	figure	NOUN
bptjm-71	158	10	5	5	NUM
bptjm-71	158	11	:	:	PUNCT
bptjm-71	158	12	comparison	comparison	NOUN
bptjm-71	158	13	of	of	ADP
bptjm-71	158	14	senolytic	senolytic	ADJ
bptjm-71	158	15	and	and	CCONJ
bptjm-71	158	16	senomorphic	senomorphic	ADJ
bptjm-71	158	17	mechanism	mechanism	NOUN
bptjm-71	158	18	of	of	ADP
bptjm-71	158	19	action	action	NOUN
bptjm-71	158	20	and	and	CCONJ
bptjm-71	158	21	effect	effect	NOUN
bptjm-71	158	22	.	.	PUNCT
bptjm-71	159	1	senolytics	senolytic	NOUN
bptjm-71	159	2	eliminate	eliminate	VERB
bptjm-71	159	3	senescent	senescent	ADJ
bptjm-71	159	4	cells	cell	NOUN
bptjm-71	159	5	,	,	PUNCT
bptjm-71	159	6	while	while	SCONJ
bptjm-71	159	7	senomorphics	senomorphic	NOUN
bptjm-71	159	8	modulate	modulate	VERB
bptjm-71	159	9	sasp	sasp	NOUN
bptjm-71	159	10	factors	factor	NOUN
bptjm-71	159	11	to	to	PART
bptjm-71	159	12	mitigate	mitigate	VERB
bptjm-71	159	13	inflammation	inflammation	NOUN
bptjm-71	159	14	without	without	ADP
bptjm-71	159	15	inducing	induce	VERB
bptjm-71	159	16	apoptosis	apoptosis	NOUN
bptjm-71	159	17	.	.	PUNCT
bptjm-71	160	1	metformin	metformin	NOUN
bptjm-71	160	2	metformin	metformin	PROPN
bptjm-71	160	3	has	have	VERB
bptjm-71	160	4	a	a	DET
bptjm-71	160	5	neuroprotective	neuroprotective	ADJ
bptjm-71	160	6	effect	effect	NOUN
bptjm-71	160	7	in	in	ADP
bptjm-71	160	8	animal	animal	NOUN
bptjm-71	160	9	models	model	NOUN
bptjm-71	160	10	,	,	PUNCT
bptjm-71	160	11	and	and	CCONJ
bptjm-71	160	12	is	be	AUX
bptjm-71	160	13	shown	show	VERB
bptjm-71	160	14	to	to	PART
bptjm-71	160	15	reduce	reduce	VERB
bptjm-71	160	16	inflammation	inflammation	NOUN
bptjm-71	160	17	and	and	CCONJ
bptjm-71	160	18	oxidative	oxidative	ADJ
bptjm-71	160	19	stress.57	stress.57	ADJ
bptjm-71	160	20	metformin	metformin	NOUN
bptjm-71	160	21	is	be	AUX
bptjm-71	160	22	a	a	DET
bptjm-71	160	23	drug	drug	NOUN
bptjm-71	160	24	that	that	PRON
bptjm-71	160	25	was	be	AUX
bptjm-71	160	26	originally	originally	ADV
bptjm-71	160	27	approved	approve	VERB
bptjm-71	160	28	for	for	ADP
bptjm-71	160	29	the	the	DET
bptjm-71	160	30	treatment	treatment	NOUN
bptjm-71	160	31	of	of	ADP
bptjm-71	160	32	type	type	NOUN
bptjm-71	160	33	2	2	NUM
bptjm-71	160	34	diabetes	diabetes	NOUN
bptjm-71	160	35	,	,	PUNCT
bptjm-71	160	36	but	but	CCONJ
bptjm-71	160	37	its	its	PRON
bptjm-71	160	38	therapeutic	therapeutic	ADJ
bptjm-71	160	39	effects	effect	NOUN
bptjm-71	160	40	have	have	AUX
bptjm-71	160	41	expanded	expand	VERB
bptjm-71	160	42	into	into	ADP
bptjm-71	160	43	age	age	NOUN
bptjm-71	160	44	-	-	PUNCT
bptjm-71	160	45	related	relate	VERB
bptjm-71	160	46	disorders	disorder	NOUN
bptjm-71	160	47	and	and	CCONJ
bptjm-71	160	48	neurodegenerative	neurodegenerative	ADJ
bptjm-71	160	49	diseases	disease	NOUN
bptjm-71	160	50	.	.	PUNCT
bptjm-71	161	1	it	it	PRON
bptjm-71	161	2	is	be	AUX
bptjm-71	161	3	effective	effective	ADJ
bptjm-71	161	4	in	in	ADP
bptjm-71	161	5	suppressing	suppress	VERB
bptjm-71	161	6	cellular	cellular	ADJ
bptjm-71	161	7	senescence	senescence	NOUN
bptjm-71	161	8	and	and	CCONJ
bptjm-71	161	9	sasps	sasp	NOUN
bptjm-71	161	10	;	;	PUNCT
bptjm-71	161	11	for	for	ADP
bptjm-71	161	12	example	example	NOUN
bptjm-71	161	13	,	,	PUNCT
bptjm-71	161	14	metformin	metformin	NOUN
bptjm-71	161	15	reduced	reduce	VERB
bptjm-71	161	16	cellular	cellular	ADJ
bptjm-71	161	17	sa	sa	PROPN
bptjm-71	161	18	-	-	PUNCT
bptjm-71	161	19	β	β	NOUN
bptjm-71	161	20	-	-	ADJ
bptjm-71	161	21	gal	gal	ADJ
bptjm-71	161	22	activity	activity	NOUN
bptjm-71	161	23	and	and	CCONJ
bptjm-71	161	24	down	down	ADV
bptjm-71	161	25	-	-	PUNCT
bptjm-71	161	26	regulated	regulate	VERB
bptjm-71	161	27	the	the	DET
bptjm-71	161	28	expression	expression	NOUN
bptjm-71	161	29	of	of	ADP
bptjm-71	161	30	senescence	senescence	NOUN
bptjm-71	161	31	and	and	CCONJ
bptjm-71	161	32	sasp	sasp	NOUN
bptjm-71	161	33	factors	factor	NOUN
bptjm-71	161	34	in	in	ADP
bptjm-71	161	35	human	human	ADJ
bptjm-71	161	36	diploid	diploid	ADJ
bptjm-71	161	37	fibroblasts	fibroblast	NOUN
bptjm-71	161	38	—	—	PUNCT
bptjm-71	161	39	cells	cell	NOUN
bptjm-71	161	40	commonly	commonly	ADV
bptjm-71	161	41	found	find	VERB
bptjm-71	161	42	in	in	ADP
bptjm-71	161	43	the	the	DET
bptjm-71	161	44	perivascular	perivascular	ADJ
bptjm-71	161	45	spaces	space	NOUN
bptjm-71	161	46	,	,	PUNCT
bptjm-71	161	47	meninges	meninge	NOUN
bptjm-71	161	48	,	,	PUNCT
bptjm-71	161	49	and	and	CCONJ
bptjm-71	161	50	choroid	choroid	NOUN
bptjm-71	161	51	plexus	plexus	NOUN
bptjm-71	161	52	of	of	ADP
bptjm-71	161	53	the	the	DET
bptjm-71	161	54	brain	brain	NOUN
bptjm-71	161	55	—	—	PUNCT
bptjm-71	161	56	among	among	ADP
bptjm-71	161	57	other	other	ADJ
bptjm-71	161	58	cells.58,59	cells.58,59	NOUN
bptjm-71	161	59	metformin	metformin	NOUN
bptjm-71	161	60	also	also	ADV
bptjm-71	161	61	increases	increase	VERB
bptjm-71	161	62	the	the	DET
bptjm-71	161	63	lifespan	lifespan	NOUN
bptjm-71	161	64	of	of	ADP
bptjm-71	161	65	different	different	ADJ
bptjm-71	161	66	model	model	NOUN
bptjm-71	161	67	organisms	organism	NOUN
bptjm-71	161	68	,	,	PUNCT
bptjm-71	161	69	including	include	VERB
bptjm-71	161	70	mice.60	mice.60	PROPN
bptjm-71	161	71	despite	despite	SCONJ
bptjm-71	161	72	the	the	DET
bptjm-71	161	73	fact	fact	NOUN
bptjm-71	161	74	that	that	SCONJ
bptjm-71	161	75	metformin	metformin	NOUN
bptjm-71	161	76	has	have	AUX
bptjm-71	161	77	been	be	AUX
bptjm-71	161	78	tested	test	VERB
bptjm-71	161	79	in	in	ADP
bptjm-71	161	80	detail	detail	NOUN
bptjm-71	161	81	,	,	PUNCT
bptjm-71	161	82	its	its	PRON
bptjm-71	161	83	exact	exact	ADJ
bptjm-71	161	84	mechanism	mechanism	NOUN
bptjm-71	161	85	of	of	ADP
bptjm-71	161	86	action	action	NOUN
bptjm-71	161	87	remains	remain	VERB
bptjm-71	161	88	unknown	unknown	ADJ
bptjm-71	161	89	,	,	PUNCT
bptjm-71	161	90	and	and	CCONJ
bptjm-71	161	91	is	be	AUX
bptjm-71	161	92	an	an	DET
bptjm-71	161	93	area	area	NOUN
bptjm-71	161	94	for	for	ADP
bptjm-71	161	95	further	further	ADJ
bptjm-71	161	96	experimentation	experimentation	NOUN
bptjm-71	161	97	and	and	CCONJ
bptjm-71	161	98	testing	testing	NOUN
bptjm-71	161	99	.	.	PUNCT
bptjm-71	162	1	metformin	metformin	NOUN
bptjm-71	162	2	has	have	AUX
bptjm-71	162	3	been	be	AUX
bptjm-71	162	4	proven	prove	VERB
bptjm-71	162	5	to	to	PART
bptjm-71	162	6	reduce	reduce	VERB
bptjm-71	162	7	senescence	senescence	NOUN
bptjm-71	162	8	via	via	ADP
bptjm-71	162	9	transcriptional	transcriptional	ADJ
bptjm-71	162	10	up	up	ADJ
bptjm-71	162	11	-	-	PUNCT
bptjm-71	162	12	regulation	regulation	NOUN
bptjm-71	162	13	of	of	ADP
bptjm-71	162	14	nrf2	nrf2	NOUN
bptjm-71	162	15	-	-	PUNCT
bptjm-71	162	16	medicated	medicate	VERB
bptjm-71	162	17	gpx7	gpx7	NOUN
bptjm-71	162	18	in	in	ADP
bptjm-71	162	19	human	human	ADJ
bptjm-71	162	20	diploid	diploid	ADJ
bptjm-71	162	21	fibroblasts	fibroblast	NOUN
bptjm-71	162	22	,	,	PUNCT
bptjm-71	162	23	but	but	CCONJ
bptjm-71	162	24	it	it	PRON
bptjm-71	162	25	also	also	ADV
bptjm-71	162	26	decreases	decrease	VERB
bptjm-71	162	27	cellular	cellular	ADJ
bptjm-71	162	28	senescence	senescence	NOUN
bptjm-71	162	29	and	and	CCONJ
bptjm-71	162	30	sasps	sasp	NOUN
bptjm-71	162	31	via	via	ADP
bptjm-71	162	32	the	the	DET
bptjm-71	162	33	microrna	microrna	PROPN
bptjm-71	162	34	processing	processing	NOUN
bptjm-71	162	35	protein	protein	NOUN
bptjm-71	162	36	dicer1.61,62	dicer1.61,62	ADJ
bptjm-71	162	37	metformin	metformin	NOUN
bptjm-71	162	38	has	have	AUX
bptjm-71	162	39	been	be	AUX
bptjm-71	162	40	found	find	VERB
bptjm-71	162	41	to	to	PART
bptjm-71	162	42	influence	influence	VERB
bptjm-71	162	43	all	all	DET
bptjm-71	162	44	hallmarks	hallmark	NOUN
bptjm-71	162	45	of	of	ADP
bptjm-71	162	46	aging	aging	NOUN
bptjm-71	162	47	,	,	PUNCT
bptjm-71	162	48	which	which	PRON
bptjm-71	162	49	is	be	AUX
bptjm-71	162	50	why	why	SCONJ
bptjm-71	162	51	understanding	understand	VERB
bptjm-71	162	52	its	its	PRON
bptjm-71	162	53	mechanism	mechanism	NOUN
bptjm-71	162	54	of	of	ADP
bptjm-71	162	55	action	action	NOUN
bptjm-71	162	56	is	be	AUX
bptjm-71	162	57	so	so	ADV
bptjm-71	162	58	complicated	complicated	ADJ
bptjm-71	162	59	.	.	PUNCT
bptjm-71	163	1	its	its	PRON
bptjm-71	163	2	impact	impact	NOUN
bptjm-71	163	3	has	have	AUX
bptjm-71	163	4	been	be	AUX
bptjm-71	163	5	found	find	VERB
bptjm-71	163	6	in	in	ADP
bptjm-71	163	7	nutrient	nutrient	NOUN
bptjm-71	163	8	signaling	signal	VERB
bptjm-71	163	9	pathways	pathway	NOUN
bptjm-71	163	10	,	,	PUNCT
bptjm-71	163	11	insulin	insulin	NOUN
bptjm-71	163	12	signaling	signaling	NOUN
bptjm-71	163	13	,	,	PUNCT
bptjm-71	163	14	repairing	repair	VERB
bptjm-71	163	15	oxidative	oxidative	ADJ
bptjm-71	163	16	damage	damage	NOUN
bptjm-71	163	17	,	,	PUNCT
bptjm-71	163	18	and	and	CCONJ
bptjm-71	163	19	inhibiting	inhibit	VERB
bptjm-71	163	20	protein	protein	NOUN
bptjm-71	163	21	synthesis	synthesis	NOUN
bptjm-71	163	22	,	,	PUNCT
bptjm-71	163	23	among	among	ADP
bptjm-71	163	24	others.63	others.63	NOUN
bptjm-71	163	25	currently	currently	ADV
bptjm-71	163	26	,	,	PUNCT
bptjm-71	163	27	there	there	PRON
bptjm-71	163	28	is	be	VERB
bptjm-71	163	29	an	an	DET
bptjm-71	163	30	ongoing	ongoing	ADJ
bptjm-71	163	31	clinical	clinical	ADJ
bptjm-71	163	32	trial	trial	NOUN
bptjm-71	163	33	(	(	PUNCT
bptjm-71	163	34	nct04098666	nct04098666	NOUN
bptjm-71	163	35	)	)	PUNCT
bptjm-71	163	36	for	for	ADP
bptjm-71	163	37	alzheimer	alzheimer	PROPN
bptjm-71	163	38	’s	’s	PART
bptjm-71	163	39	prevention	prevention	NOUN
bptjm-71	163	40	using	use	VERB
bptjm-71	163	41	metformin	metformin	NOUN
bptjm-71	163	42	.	.	PUNCT
bptjm-71	164	1	at	at	ADP
bptjm-71	164	2	baseline	baseline	PROPN
bptjm-71	164	3	and	and	CCONJ
bptjm-71	164	4	after	after	ADP
bptjm-71	164	5	study	study	NOUN
bptjm-71	164	6	visit	visit	NOUN
bptjm-71	164	7	at	at	ADP
bptjm-71	164	8	18	18	NUM
bptjm-71	164	9	months	month	NOUN
bptjm-71	164	10	a	a	DET
bptjm-71	164	11	brain	brain	NOUN
bptjm-71	164	12	mri	mri	NOUN
bptjm-71	164	13	,	,	PUNCT
bptjm-71	164	14	physical	physical	ADJ
bptjm-71	164	15	exams	exam	NOUN
bptjm-71	164	16	,	,	PUNCT
bptjm-71	164	17	plasma	plasma	NOUN
bptjm-71	164	18	tau	tau	PROPN
bptjm-71	164	19	and	and	CCONJ
bptjm-71	164	20	amyloid	amyloid	NOUN
bptjm-71	164	21	beta	beta	NOUN
bptjm-71	164	22	levels	level	NOUN
bptjm-71	164	23	are	be	AUX
bptjm-71	164	24	being	be	AUX
bptjm-71	164	25	measured	measure	VERB
bptjm-71	164	26	to	to	PART
bptjm-71	164	27	assess	assess	VERB
bptjm-71	164	28	prevention	prevention	NOUN
bptjm-71	164	29	of	of	ADP
bptjm-71	164	30	ad	ad	NOUN
bptjm-71	164	31	,	,	PUNCT
bptjm-71	164	32	along	along	ADP
bptjm-71	164	33	with	with	ADP
bptjm-71	164	34	clinical	clinical	ADJ
bptjm-71	164	35	interviews	interview	NOUN
bptjm-71	164	36	,	,	PUNCT
bptjm-71	164	37	physical	physical	ADJ
bptjm-71	164	38	exams	exam	NOUN
bptjm-71	164	39	,	,	PUNCT
bptjm-71	164	40	and	and	CCONJ
bptjm-71	164	41	brain	brain	NOUN
bptjm-71	164	42	mris	mris	PROPN
bptjm-71	164	43	.	.	PUNCT
bptjm-71	165	1	results	result	NOUN
bptjm-71	165	2	are	be	AUX
bptjm-71	165	3	inconclusive	inconclusive	ADJ
bptjm-71	165	4	as	as	ADP
bptjm-71	165	5	of	of	ADP
bptjm-71	165	6	yet.57	yet.57	PROPN
bptjm-71	165	7	resveratrol	resveratrol	NOUN
bptjm-71	165	8	resveratrol	resveratrol	NOUN
bptjm-71	165	9	is	be	AUX
bptjm-71	165	10	an	an	DET
bptjm-71	165	11	sirt1	sirt1	NOUN
bptjm-71	165	12	activator	activator	NOUN
bptjm-71	165	13	that	that	PRON
bptjm-71	165	14	plays	play	VERB
bptjm-71	165	15	an	an	DET
bptjm-71	165	16	important	important	ADJ
bptjm-71	165	17	role	role	NOUN
bptjm-71	165	18	in	in	ADP
bptjm-71	165	19	promoting	promote	VERB
bptjm-71	165	20	anti	anti	ADJ
bptjm-71	165	21	-	-	ADJ
bptjm-71	165	22	inflammatory	inflammatory	ADJ
bptjm-71	165	23	and	and	CCONJ
bptjm-71	165	24	antioxidant	antioxidant	ADJ
bptjm-71	165	25	properties	property	NOUN
bptjm-71	165	26	in	in	ADP
bptjm-71	165	27	the	the	DET
bptjm-71	165	28	body	body	NOUN
bptjm-71	165	29	,	,	PUNCT
bptjm-71	165	30	and	and	CCONJ
bptjm-71	165	31	has	have	VERB
bptjm-71	165	32	an	an	DET
bptjm-71	165	33	effect	effect	NOUN
bptjm-71	165	34	on	on	ADP
bptjm-71	165	35	cellular	cellular	ADJ
bptjm-71	165	36	senescence.8	senescence.8	PROPN
bptjm-71	165	37	it	it	PRON
bptjm-71	165	38	also	also	ADV
bptjm-71	165	39	mitigates	mitigate	VERB
bptjm-71	165	40	neuroinflammation	neuroinflammation	NOUN
bptjm-71	165	41	by	by	ADP
bptjm-71	165	42	promoting	promote	VERB
bptjm-71	165	43	microglia	microglia	ADJ
bptjm-71	165	44	polarization	polarization	NOUN
bptjm-71	165	45	towards	towards	ADP
bptjm-71	165	46	the	the	DET
bptjm-71	165	47	m2	m2	PROPN
bptjm-71	165	48	phenotype	phenotype	NOUN
bptjm-71	165	49	it	it	PRON
bptjm-71	165	50	activates	activate	VERB
bptjm-71	165	51	,	,	PUNCT
bptjm-71	165	52	pgc-1α	pgc-1α	NOUN
bptjm-71	165	53	:	:	PUNCT
bptjm-71	165	54	a	a	DET
bptjm-71	165	55	transcription	transcription	NOUN
bptjm-71	165	56	factor	factor	NOUN
bptjm-71	165	57	involved	involve	VERB
bptjm-71	165	58	in	in	ADP
bptjm-71	165	59	the	the	DET
bptjm-71	165	60	suppression	suppression	NOUN
bptjm-71	165	61	of	of	ADP
bptjm-71	165	62	sasp.64	sasp.64	PROPN
bptjm-71	165	63	m2microglia	m2microglia	PROPN
bptjm-71	165	64	are	be	AUX
bptjm-71	165	65	berkeley	berkeley	PROPN
bptjm-71	165	66	pharma	pharma	PROPN
bptjm-71	165	67	tech	tech	NOUN
bptjm-71	165	68	journal	journal	NOUN
bptjm-71	165	69	of	of	ADP
bptjm-71	165	70	medicine	medicine	NOUN
bptjm-71	165	71	|	|	ADV
bptjm-71	165	72	61	61	NUM
bptjm-71	165	73	involved	involve	VERB
bptjm-71	165	74	in	in	ADP
bptjm-71	165	75	anti	anti	ADJ
bptjm-71	165	76	-	-	ADJ
bptjm-71	165	77	inflammatory	inflammatory	ADJ
bptjm-71	165	78	responses	response	NOUN
bptjm-71	165	79	;	;	PUNCT
bptjm-71	165	80	they	they	PRON
bptjm-71	165	81	promote	promote	VERB
bptjm-71	165	82	tissue	tissue	NOUN
bptjm-71	165	83	repair	repair	NOUN
bptjm-71	165	84	and	and	CCONJ
bptjm-71	165	85	protect	protect	VERB
bptjm-71	165	86	neurons	neuron	NOUN
bptjm-71	165	87	from	from	ADP
bptjm-71	165	88	damage	damage	NOUN
bptjm-71	165	89	;	;	PUNCT
bptjm-71	165	90	thus	thus	ADV
bptjm-71	165	91	,	,	PUNCT
bptjm-71	165	92	promoting	promote	VERB
bptjm-71	165	93	the	the	DET
bptjm-71	165	94	m2	m2	PROPN
bptjm-71	165	95	phenotype	phenotype	NOUN
bptjm-71	165	96	will	will	AUX
bptjm-71	165	97	help	help	VERB
bptjm-71	165	98	reduce	reduce	VERB
bptjm-71	165	99	neuroinflammation	neuroinflammation	NOUN
bptjm-71	165	100	and	and	CCONJ
bptjm-71	165	101	protect	protect	VERB
bptjm-71	165	102	neurons	neuron	NOUN
bptjm-71	165	103	from	from	ADP
bptjm-71	165	104	further	further	ADJ
bptjm-71	165	105	damage	damage	NOUN
bptjm-71	165	106	.	.	PUNCT
bptjm-71	166	1	in	in	ADP
bptjm-71	166	2	trials	trial	NOUN
bptjm-71	166	3	,	,	PUNCT
bptjm-71	166	4	long	long	ADJ
bptjm-71	166	5	term	term	NOUN
bptjm-71	166	6	resveratrol	resveratrol	NOUN
bptjm-71	166	7	treatment	treatment	NOUN
bptjm-71	166	8	prevented	prevent	VERB
bptjm-71	166	9	age	age	NOUN
bptjm-71	166	10	-	-	PUNCT
bptjm-71	166	11	dependent	dependent	ADJ
bptjm-71	166	12	decline	decline	NOUN
bptjm-71	166	13	in	in	ADP
bptjm-71	166	14	cellular	cellular	ADJ
bptjm-71	166	15	viability	viability	NOUN
bptjm-71	166	16	and	and	CCONJ
bptjm-71	166	17	various	various	ADJ
bptjm-71	166	18	cell	cell	NOUN
bptjm-71	166	19	parameters	parameter	NOUN
bptjm-71	166	20	—	—	PUNCT
bptjm-71	166	21	metabolic	metabolic	ADJ
bptjm-71	166	22	,	,	PUNCT
bptjm-71	166	23	oxidative	oxidative	ADJ
bptjm-71	166	24	,	,	PUNCT
bptjm-71	166	25	inflammatory	inflammatory	ADJ
bptjm-71	166	26	,	,	PUNCT
bptjm-71	166	27	and	and	CCONJ
bptjm-71	166	28	senescent	senescent	ADJ
bptjm-71	166	29	—	—	PUNCT
bptjm-71	166	30	in	in	ADP
bptjm-71	166	31	hypothalamic	hypothalamic	ADJ
bptjm-71	166	32	astrocytes	astrocyte	NOUN
bptjm-71	166	33	from	from	ADP
bptjm-71	166	34	aged	aged	ADJ
bptjm-71	166	35	rats	rat	NOUN
bptjm-71	166	36	.	.	PUNCT
bptjm-71	167	1	it	it	PRON
bptjm-71	167	2	also	also	ADV
bptjm-71	167	3	increased	increase	VERB
bptjm-71	167	4	the	the	DET
bptjm-71	167	5	expression	expression	NOUN
bptjm-71	167	6	of	of	ADP
bptjm-71	167	7	genes	gene	NOUN
bptjm-71	167	8	involved	involve	VERB
bptjm-71	167	9	in	in	ADP
bptjm-71	167	10	cellular	cellular	ADJ
bptjm-71	167	11	homeostasis	homeostasis	NOUN
bptjm-71	167	12	,	,	PUNCT
bptjm-71	167	13	such	such	ADJ
bptjm-71	167	14	as	as	ADP
bptjm-71	167	15	:	:	PUNCT
bptjm-71	167	16	nrf2	nrf2	NOUN
bptjm-71	167	17	,	,	PUNCT
bptjm-71	167	18	ho-1	ho-1	ADV
bptjm-71	167	19	,	,	PUNCT
bptjm-71	167	20	sirt1	sirt1	NOUN
bptjm-71	167	21	,	,	PUNCT
bptjm-71	167	22	and	and	CCONJ
bptjm-71	167	23	pgc-1α.65,66	pgc-1α.65,66	NOUN
bptjm-71	167	24	however	however	ADV
bptjm-71	167	25	,	,	PUNCT
bptjm-71	167	26	resveratrol	resveratrol	NOUN
bptjm-71	167	27	has	have	VERB
bptjm-71	167	28	a	a	DET
bptjm-71	167	29	biphasic	biphasic	ADJ
bptjm-71	167	30	effect	effect	NOUN
bptjm-71	167	31	.	.	PUNCT
bptjm-71	168	1	at	at	ADP
bptjm-71	168	2	low	low	ADJ
bptjm-71	168	3	concentrations	concentration	NOUN
bptjm-71	168	4	(	(	PUNCT
bptjm-71	168	5	below	below	ADP
bptjm-71	168	6	10	10	NUM
bptjm-71	168	7	μm	μm	NUM
bptjm-71	168	8	)	)	PUNCT
bptjm-71	168	9	,	,	PUNCT
bptjm-71	168	10	resveratrol	resveratrol	NOUN
bptjm-71	168	11	acts	act	NOUN
bptjm-71	168	12	as	as	ADP
bptjm-71	168	13	a	a	DET
bptjm-71	168	14	senomorphic	senomorphic	NOUN
bptjm-71	168	15	and	and	CCONJ
bptjm-71	168	16	prevents	prevent	VERB
bptjm-71	168	17	cellular	cellular	ADJ
bptjm-71	168	18	senescence	senescence	NOUN
bptjm-71	168	19	and	and	CCONJ
bptjm-71	168	20	suppresses	suppress	VERB
bptjm-71	168	21	sasps	sasps	NOUN
bptjm-71	168	22	.	.	PUNCT
bptjm-71	169	1	for	for	ADP
bptjm-71	169	2	example	example	NOUN
bptjm-71	169	3	,	,	PUNCT
bptjm-71	169	4	resveratrol	resveratrol	NOUN
bptjm-71	169	5	prevented	prevent	VERB
bptjm-71	169	6	cellular	cellular	ADJ
bptjm-71	169	7	senescence	senescence	NOUN
bptjm-71	169	8	by	by	ADP
bptjm-71	169	9	activating	activate	VERB
bptjm-71	169	10	the	the	DET
bptjm-71	169	11	telomerase	telomerase	NOUN
bptjm-71	169	12	of	of	ADP
bptjm-71	169	13	endothelial	endothelial	ADJ
bptjm-71	169	14	progenitor	progenitor	NOUN
bptjm-71	169	15	cells	cell	NOUN
bptjm-71	169	16	via	via	ADP
bptjm-71	169	17	the	the	DET
bptjm-71	169	18	p13k	p13k	NOUN
bptjm-71	169	19	-	-	PUNCT
bptjm-71	169	20	akt	akt	NOUN
bptjm-71	169	21	pathway.67	pathway.67	NOUN
bptjm-71	169	22	the	the	DET
bptjm-71	169	23	drug	drug	NOUN
bptjm-71	169	24	has	have	AUX
bptjm-71	169	25	also	also	ADV
bptjm-71	169	26	been	be	AUX
bptjm-71	169	27	shown	show	VERB
bptjm-71	169	28	to	to	PART
bptjm-71	169	29	suppress	suppress	VERB
bptjm-71	169	30	sasp	sasp	NOUN
bptjm-71	169	31	factors	factor	NOUN
bptjm-71	169	32	by	by	ADP
bptjm-71	169	33	inhibiting	inhibit	VERB
bptjm-71	169	34	nf	nf	NOUN
bptjm-71	169	35	-	-	PUNCT
bptjm-71	169	36	κb	κb	NOUN
bptjm-71	169	37	and	and	CCONJ
bptjm-71	169	38	upregulating	upregulating	ADJ
bptjm-71	169	39	nrf2	nrf2	PROPN
bptjm-71	169	40	pathways	pathway	NOUN
bptjm-71	169	41	in	in	ADP
bptjm-71	169	42	the	the	DET
bptjm-71	169	43	vascular	vascular	ADJ
bptjm-71	169	44	smooth	smooth	ADJ
bptjm-71	169	45	muscle	muscle	NOUN
bptjm-71	169	46	cells	cell	NOUN
bptjm-71	169	47	of	of	ADP
bptjm-71	169	48	rhesus	rhesus	NOUN
bptjm-71	169	49	monkeys	monkey	NOUN
bptjm-71	169	50	.	.	PUNCT
bptjm-71	170	1	however	however	ADV
bptjm-71	170	2	,	,	PUNCT
bptjm-71	170	3	at	at	ADP
bptjm-71	170	4	higher	high	ADJ
bptjm-71	170	5	concentrations	concentration	NOUN
bptjm-71	170	6	(	(	PUNCT
bptjm-71	170	7	over	over	ADP
bptjm-71	170	8	25	25	NUM
bptjm-71	170	9	μm	μm	NUM
bptjm-71	170	10	)	)	PUNCT
bptjm-71	170	11	,	,	PUNCT
bptjm-71	170	12	resveratrol	resveratrol	NOUN
bptjm-71	170	13	triggers	trigger	VERB
bptjm-71	170	14	growth	growth	NOUN
bptjm-71	170	15	arrest	arrest	NOUN
bptjm-71	170	16	and	and	CCONJ
bptjm-71	170	17	induces	induce	VERB
bptjm-71	170	18	senescence	senescence	NOUN
bptjm-71	170	19	of	of	ADP
bptjm-71	170	20	apoptotic	apoptotic	ADJ
bptjm-71	170	21	death	death	NOUN
bptjm-71	170	22	in	in	ADP
bptjm-71	170	23	cell	cell	NOUN
bptjm-71	170	24	lines	line	NOUN
bptjm-71	170	25	.	.	PUNCT
bptjm-71	171	1	as	as	ADP
bptjm-71	171	2	such	such	ADJ
bptjm-71	171	3	,	,	PUNCT
bptjm-71	171	4	controlling	control	VERB
bptjm-71	171	5	the	the	DET
bptjm-71	171	6	dosage	dosage	NOUN
bptjm-71	171	7	of	of	ADP
bptjm-71	171	8	resveratrol	resveratrol	NOUN
bptjm-71	171	9	is	be	AUX
bptjm-71	171	10	very	very	ADV
bptjm-71	171	11	important	important	ADJ
bptjm-71	171	12	for	for	ADP
bptjm-71	171	13	using	use	VERB
bptjm-71	171	14	it	it	PRON
bptjm-71	171	15	as	as	ADP
bptjm-71	171	16	a	a	DET
bptjm-71	171	17	senomorphic	senomorphic	ADJ
bptjm-71	171	18	therapy	therapy	NOUN
bptjm-71	171	19	.	.	PUNCT
bptjm-71	172	1	rapamycin	rapamycin	PROPN
bptjm-71	172	2	rapamycin	rapamycin	PROPN
bptjm-71	172	3	is	be	AUX
bptjm-71	172	4	also	also	ADV
bptjm-71	172	5	known	know	VERB
bptjm-71	172	6	as	as	ADP
bptjm-71	172	7	sirolimus	sirolimus	NOUN
bptjm-71	172	8	.	.	PUNCT
bptjm-71	173	1	while	while	SCONJ
bptjm-71	173	2	it	it	PRON
bptjm-71	173	3	was	be	AUX
bptjm-71	173	4	originally	originally	ADV
bptjm-71	173	5	used	use	VERB
bptjm-71	173	6	as	as	ADP
bptjm-71	173	7	an	an	DET
bptjm-71	173	8	immunosuppressive	immunosuppressive	ADJ
bptjm-71	173	9	drug	drug	NOUN
bptjm-71	173	10	for	for	ADP
bptjm-71	173	11	the	the	DET
bptjm-71	173	12	prevention	prevention	NOUN
bptjm-71	173	13	of	of	ADP
bptjm-71	173	14	organ	organ	NOUN
bptjm-71	173	15	rejection	rejection	NOUN
bptjm-71	173	16	in	in	ADP
bptjm-71	173	17	kidney	kidney	NOUN
bptjm-71	173	18	transplantation	transplantation	NOUN
bptjm-71	173	19	,	,	PUNCT
bptjm-71	173	20	studies	study	NOUN
bptjm-71	173	21	have	have	AUX
bptjm-71	173	22	shown	show	VERB
bptjm-71	173	23	that	that	SCONJ
bptjm-71	173	24	rapamycin	rapamycin	PROPN
bptjm-71	173	25	could	could	AUX
bptjm-71	173	26	reduce	reduce	VERB
bptjm-71	173	27	cellular	cellular	ADJ
bptjm-71	173	28	senescence	senescence	NOUN
bptjm-71	173	29	and	and	CCONJ
bptjm-71	173	30	suppress	suppress	ADJ
bptjm-71	173	31	sasp	sasp	NOUN
bptjm-71	173	32	markers	marker	NOUN
bptjm-71	173	33	in	in	ADP
bptjm-71	173	34	a	a	DET
bptjm-71	173	35	variety	variety	NOUN
bptjm-71	173	36	of	of	ADP
bptjm-71	173	37	mouse	mouse	NOUN
bptjm-71	173	38	and	and	CCONJ
bptjm-71	173	39	human	human	ADJ
bptjm-71	173	40	cell	cell	NOUN
bptjm-71	173	41	lines	line	NOUN
bptjm-71	173	42	.	.	PUNCT
bptjm-71	174	1	it	it	PRON
bptjm-71	174	2	is	be	AUX
bptjm-71	174	3	an	an	DET
bptjm-71	174	4	incredibly	incredibly	ADV
bptjm-71	174	5	well	well	ADV
bptjm-71	174	6	-	-	PUNCT
bptjm-71	174	7	established	establish	VERB
bptjm-71	174	8	senomorphic	senomorphic	ADJ
bptjm-71	174	9	drug	drug	NOUN
bptjm-71	174	10	.	.	PUNCT
bptjm-71	175	1	in	in	ADP
bptjm-71	175	2	multiple	multiple	ADJ
bptjm-71	175	3	invertebrate	invertebrate	NOUN
bptjm-71	175	4	models	model	NOUN
bptjm-71	175	5	,	,	PUNCT
bptjm-71	175	6	including	include	VERB
bptjm-71	175	7	yeast	yeast	NOUN
bptjm-71	175	8	,	,	PUNCT
bptjm-71	175	9	flies	fly	NOUN
bptjm-71	175	10	,	,	PUNCT
bptjm-71	175	11	and	and	CCONJ
bptjm-71	175	12	worms	worm	NOUN
bptjm-71	175	13	,	,	PUNCT
bptjm-71	175	14	rapamycin	rapamycin	PROPN
bptjm-71	175	15	has	have	AUX
bptjm-71	175	16	increased	increase	VERB
bptjm-71	175	17	lifespan	lifespan	NOUN
bptjm-71	175	18	,	,	PUNCT
bptjm-71	175	19	and	and	CCONJ
bptjm-71	175	20	late	late	ADJ
bptjm-71	175	21	-	-	PUNCT
bptjm-71	175	22	life	life	NOUN
bptjm-71	175	23	administration	administration	NOUN
bptjm-71	175	24	has	have	AUX
bptjm-71	175	25	extended	extend	VERB
bptjm-71	175	26	lifespan	lifespan	NOUN
bptjm-71	175	27	in	in	ADP
bptjm-71	175	28	male	male	ADJ
bptjm-71	175	29	and	and	CCONJ
bptjm-71	175	30	female	female	ADJ
bptjm-71	175	31	mice	mouse	NOUN
bptjm-71	175	32	.	.	PUNCT
bptjm-71	176	1	in	in	ADP
bptjm-71	176	2	vivo	vivo	ADJ
bptjm-71	176	3	studies	study	NOUN
bptjm-71	176	4	have	have	AUX
bptjm-71	176	5	demonstrated	demonstrate	VERB
bptjm-71	176	6	that	that	SCONJ
bptjm-71	176	7	rapamycin	rapamycin	NOUN
bptjm-71	176	8	alleviates	alleviate	VERB
bptjm-71	176	9	age	age	NOUN
bptjm-71	176	10	-	-	PUNCT
bptjm-71	176	11	related	relate	VERB
bptjm-71	176	12	dysfunctions	dysfunction	NOUN
bptjm-71	176	13	,	,	PUNCT
bptjm-71	176	14	decreases	decrease	VERB
bptjm-71	176	15	aging	age	VERB
bptjm-71	176	16	rate	rate	NOUN
bptjm-71	176	17	,	,	PUNCT
bptjm-71	176	18	and	and	CCONJ
bptjm-71	176	19	increases	increase	VERB
bptjm-71	176	20	life	life	NOUN
bptjm-71	176	21	-	-	PUNCT
bptjm-71	176	22	span	span	NOUN
bptjm-71	176	23	.	.	PUNCT
bptjm-71	177	1	further	far	ADV
bptjm-71	177	2	,	,	PUNCT
bptjm-71	177	3	rapamycin	rapamycin	NOUN
bptjm-71	177	4	treatment	treatment	NOUN
bptjm-71	177	5	has	have	AUX
bptjm-71	177	6	reversed	reverse	VERB
bptjm-71	177	7	the	the	DET
bptjm-71	177	8	cellular	cellular	ADJ
bptjm-71	177	9	senescence	senescence	NOUN
bptjm-71	177	10	phenotype	phenotype	NOUN
bptjm-71	177	11	in	in	ADP
bptjm-71	177	12	ppms	ppm	NOUN
bptjm-71	177	13	npcs	npc	NOUN
bptjm-71	177	14	,	,	PUNCT
bptjm-71	177	15	as	as	SCONJ
bptjm-71	177	16	evidenced	evidence	VERB
bptjm-71	177	17	by	by	ADP
bptjm-71	177	18	the	the	DET
bptjm-71	177	19	reduced	reduce	VERB
bptjm-71	177	20	expression	expression	NOUN
bptjm-71	177	21	of	of	ADP
bptjm-71	177	22	senescence	senescence	NOUN
bptjm-71	177	23	markers	marker	NOUN
bptjm-71	177	24	and	and	CCONJ
bptjm-71	177	25	increased	increase	VERB
bptjm-71	177	26	cellular	cellular	ADJ
bptjm-71	177	27	proliferation	proliferation	NOUN
bptjm-71	177	28	.	.	PUNCT
bptjm-71	178	1	it	it	PRON
bptjm-71	178	2	further	far	ADV
bptjm-71	178	3	enhanced	enhance	VERB
bptjm-71	178	4	the	the	DET
bptjm-71	178	5	ppms	ppm	NOUN
bptjm-71	178	6	npc	npc	NOUN
bptjm-71	178	7	support	support	NOUN
bptjm-71	178	8	for	for	ADP
bptjm-71	178	9	olg	olg	NOUN
bptjm-71	178	10	maturation	maturation	NOUN
bptjm-71	178	11	,	,	PUNCT
bptjm-71	178	12	as	as	SCONJ
bptjm-71	178	13	seen	see	VERB
bptjm-71	178	14	in	in	ADP
bptjm-71	178	15	the	the	DET
bptjm-71	178	16	increased	increase	VERB
bptjm-71	178	17	expression	expression	NOUN
bptjm-71	178	18	of	of	ADP
bptjm-71	178	19	olg	olg	PROPN
bptjm-71	178	20	differentiation	differentiation	NOUN
bptjm-71	178	21	markers	marker	NOUN
bptjm-71	178	22	and	and	CCONJ
bptjm-71	178	23	decreased	decrease	VERB
bptjm-71	178	24	hmgb1	hmgb1	PROPN
bptjm-71	178	25	secretion.16	secretion.16	PROPN
bptjm-71	178	26	decreased	decrease	VERB
bptjm-71	178	27	hmgb1	hmgb1	PROPN
bptjm-71	178	28	secretion	secretion	NOUN
bptjm-71	178	29	is	be	AUX
bptjm-71	178	30	important	important	ADJ
bptjm-71	178	31	;	;	PUNCT
bptjm-71	178	32	it	it	PRON
bptjm-71	178	33	is	be	AUX
bptjm-71	178	34	seen	see	VERB
bptjm-71	178	35	that	that	SCONJ
bptjm-71	178	36	patients	patient	NOUN
bptjm-71	178	37	with	with	ADP
bptjm-71	178	38	pms	pm	NOUN
bptjm-71	178	39	exhibit	exhibit	VERB
bptjm-71	178	40	higher	high	ADJ
bptjm-71	178	41	levels	level	NOUN
bptjm-71	178	42	of	of	ADP
bptjm-71	178	43	hmgb1	hmgb1	PROPN
bptjm-71	178	44	,	,	PUNCT
bptjm-71	178	45	a	a	DET
bptjm-71	178	46	senescence	senescence	NOUN
bptjm-71	178	47	marker	marker	NOUN
bptjm-71	178	48	,	,	PUNCT
bptjm-71	178	49	berkeley	berkeley	PROPN
bptjm-71	178	50	pharma	pharma	PROPN
bptjm-71	178	51	tech	tech	NOUN
bptjm-71	178	52	journal	journal	NOUN
bptjm-71	178	53	of	of	ADP
bptjm-71	178	54	medicine	medicine	NOUN
bptjm-71	178	55	|	|	ADV
bptjm-71	178	56	62	62	NUM
bptjm-71	178	57	which	which	PRON
bptjm-71	178	58	inhibits	inhibit	VERB
bptjm-71	178	59	the	the	DET
bptjm-71	178	60	differentiation	differentiation	NOUN
bptjm-71	178	61	of	of	ADP
bptjm-71	178	62	progenitor	progenitor	NOUN
bptjm-71	178	63	cells	cell	NOUN
bptjm-71	178	64	into	into	ADP
bptjm-71	178	65	olgs	olgs	NOUN
bptjm-71	178	66	.	.	PUNCT
bptjm-71	179	1	this	this	PRON
bptjm-71	179	2	is	be	AUX
bptjm-71	179	3	incredibly	incredibly	ADV
bptjm-71	179	4	important	important	ADJ
bptjm-71	179	5	for	for	ADP
bptjm-71	179	6	neurodegenerative	neurodegenerative	ADJ
bptjm-71	179	7	disease	disease	NOUN
bptjm-71	179	8	progression	progression	NOUN
bptjm-71	179	9	,	,	PUNCT
bptjm-71	179	10	as	as	SCONJ
bptjm-71	179	11	olgs	olgs	NOUN
bptjm-71	179	12	are	be	AUX
bptjm-71	179	13	what	what	PRON
bptjm-71	179	14	produce	produce	VERB
bptjm-71	179	15	myelin	myelin	NOUN
bptjm-71	179	16	to	to	PART
bptjm-71	179	17	protect	protect	VERB
bptjm-71	179	18	our	our	PRON
bptjm-71	179	19	neurons.16	neurons.16	PROPN
bptjm-71	179	20	rapamycin	rapamycin	NOUN
bptjm-71	179	21	has	have	VERB
bptjm-71	179	22	side	side	NOUN
bptjm-71	179	23	-	-	PUNCT
bptjm-71	179	24	effects	effect	NOUN
bptjm-71	179	25	,	,	PUNCT
bptjm-71	179	26	however	however	ADV
bptjm-71	179	27	:	:	PUNCT
bptjm-71	179	28	metabolic	metabolic	NOUN
bptjm-71	179	29	dysregulation	dysregulation	NOUN
bptjm-71	179	30	and	and	CCONJ
bptjm-71	179	31	impaired	impaired	ADJ
bptjm-71	179	32	wound	wound	NOUN
bptjm-71	179	33	healing	healing	NOUN
bptjm-71	179	34	,	,	PUNCT
bptjm-71	179	35	among	among	ADP
bptjm-71	179	36	others	other	NOUN
bptjm-71	179	37	.	.	PUNCT
bptjm-71	180	1	rapamycin	rapamycin	PROPN
bptjm-71	180	2	works	work	VERB
bptjm-71	180	3	by	by	ADP
bptjm-71	180	4	inhibiting	inhibit	VERB
bptjm-71	180	5	torc1	torc1	PRON
bptjm-71	180	6	activity	activity	NOUN
bptjm-71	180	7	in	in	ADP
bptjm-71	180	8	association	association	NOUN
bptjm-71	180	9	with	with	ADP
bptjm-71	180	10	the	the	DET
bptjm-71	180	11	intracellular	intracellular	ADJ
bptjm-71	180	12	protein	protein	NOUN
bptjm-71	180	13	fkbp12	fkbp12	NOUN
bptjm-71	180	14	.	.	PUNCT
bptjm-71	181	1	torc1	torc1	ADV
bptjm-71	181	2	,	,	PUNCT
bptjm-71	181	3	or	or	CCONJ
bptjm-71	181	4	target	target	NOUN
bptjm-71	181	5	of	of	ADP
bptjm-71	181	6	rapamycin	rapamycin	NOUN
bptjm-71	181	7	complex	complex	ADJ
bptjm-71	181	8	1	1	NUM
bptjm-71	181	9	,	,	PUNCT
bptjm-71	181	10	is	be	AUX
bptjm-71	181	11	a	a	DET
bptjm-71	181	12	eukaryotic	eukaryotic	ADJ
bptjm-71	181	13	protein	protein	NOUN
bptjm-71	181	14	complex	complex	NOUN
bptjm-71	181	15	related	relate	VERB
bptjm-71	181	16	to	to	ADP
bptjm-71	181	17	cell	cell	NOUN
bptjm-71	181	18	proliferation.68	proliferation.68	ADJ
bptjm-71	181	19	the	the	DET
bptjm-71	181	20	senomorphic	senomorphic	ADJ
bptjm-71	181	21	and	and	CCONJ
bptjm-71	181	22	longevity	longevity	NOUN
bptjm-71	181	23	effects	effect	NOUN
bptjm-71	181	24	of	of	ADP
bptjm-71	181	25	rapamycin	rapamycin	NOUN
bptjm-71	181	26	relate	relate	VERB
bptjm-71	181	27	to	to	ADP
bptjm-71	181	28	its	its	PRON
bptjm-71	181	29	inhibition	inhibition	NOUN
bptjm-71	181	30	of	of	ADP
bptjm-71	181	31	mtor	mtor	NOUN
bptjm-71	181	32	signaling	signal	VERB
bptjm-71	181	33	by	by	ADP
bptjm-71	181	34	reducing	reduce	VERB
bptjm-71	181	35	the	the	DET
bptjm-71	181	36	phosphorylation	phosphorylation	NOUN
bptjm-71	181	37	of	of	ADP
bptjm-71	181	38	s6k	s6k	PROPN
bptjm-71	181	39	and	and	CCONJ
bptjm-71	181	40	4e	4e	PROPN
bptjm-71	181	41	-	-	PUNCT
bptjm-71	181	42	bp	bp	PROPN
bptjm-71	181	43	.	.	PUNCT
bptjm-71	182	1	other	other	ADJ
bptjm-71	182	2	potential	potential	ADJ
bptjm-71	182	3	or	or	CCONJ
bptjm-71	182	4	secondary	secondary	ADJ
bptjm-71	182	5	mechanisms	mechanism	NOUN
bptjm-71	182	6	by	by	ADP
bptjm-71	182	7	which	which	PRON
bptjm-71	182	8	rapamycin	rapamycin	NOUN
bptjm-71	182	9	may	may	AUX
bptjm-71	182	10	regulate	regulate	VERB
bptjm-71	182	11	senescence	senescence	NOUN
bptjm-71	182	12	and	and	CCONJ
bptjm-71	182	13	lifespan	lifespan	NOUN
bptjm-71	182	14	are	be	AUX
bptjm-71	182	15	being	be	AUX
bptjm-71	182	16	explored	explore	VERB
bptjm-71	182	17	—	—	PUNCT
bptjm-71	182	18	for	for	ADP
bptjm-71	182	19	example	example	NOUN
bptjm-71	182	20	,	,	PUNCT
bptjm-71	182	21	activating	activate	VERB
bptjm-71	182	22	the	the	DET
bptjm-71	182	23	nrf2	nrf2	NOUN
bptjm-71	182	24	pathway	pathway	NOUN
bptjm-71	182	25	and	and	CCONJ
bptjm-71	182	26	decreasing	decrease	VERB
bptjm-71	182	27	nf	nf	ADJ
bptjm-71	182	28	-	-	PUNCT
bptjm-71	182	29	κb	κb	NOUN
bptjm-71	182	30	activity	activity	NOUN
bptjm-71	182	31	to	to	PART
bptjm-71	182	32	reduce	reduce	VERB
bptjm-71	182	33	il-1α	il-1α	PROPN
bptjm-71	182	34	production	production	NOUN
bptjm-71	182	35	.	.	PUNCT
bptjm-71	183	1	it	it	PRON
bptjm-71	183	2	is	be	AUX
bptjm-71	183	3	also	also	ADV
bptjm-71	183	4	to	to	PART
bptjm-71	183	5	be	be	AUX
bptjm-71	183	6	determined	determine	VERB
bptjm-71	183	7	whether	whether	SCONJ
bptjm-71	183	8	other	other	ADJ
bptjm-71	183	9	mtor	mtor	NOUN
bptjm-71	183	10	pathway	pathway	NOUN
bptjm-71	183	11	inhibitors	inhibitor	NOUN
bptjm-71	183	12	and	and	CCONJ
bptjm-71	183	13	rapalogues	rapalogue	NOUN
bptjm-71	183	14	such	such	ADJ
bptjm-71	183	15	as	as	ADP
bptjm-71	183	16	everolimus	everolimus	NOUN
bptjm-71	183	17	,	,	PUNCT
bptjm-71	183	18	temsirolimus	temsirolimus	NOUN
bptjm-71	183	19	,	,	PUNCT
bptjm-71	183	20	deforolimus	deforolimus	NOUN
bptjm-71	183	21	,	,	PUNCT
bptjm-71	183	22	ridaforolimus	ridaforolimus	NOUN
bptjm-71	183	23	and	and	CCONJ
bptjm-71	183	24	zotarolimus	zotarolimus	NOUN
bptjm-71	183	25	may	may	AUX
bptjm-71	183	26	exhibit	exhibit	VERB
bptjm-71	183	27	senomorphic	senomorphic	ADJ
bptjm-71	183	28	activities.63	activities.63	PROPN
bptjm-71	183	29	aspirin	aspirin	NOUN
bptjm-71	183	30	aspirin	aspirin	NOUN
bptjm-71	183	31	has	have	AUX
bptjm-71	183	32	been	be	AUX
bptjm-71	183	33	found	find	VERB
bptjm-71	183	34	to	to	PART
bptjm-71	183	35	partially	partially	ADV
bptjm-71	183	36	prevent	prevent	VERB
bptjm-71	183	37	aβ	aβ	NOUN
bptjm-71	183	38	-	-	PUNCT
bptjm-71	183	39	induced	induce	VERB
bptjm-71	183	40	neuronal	neuronal	ADJ
bptjm-71	183	41	senescence	senescence	NOUN
bptjm-71	183	42	and	and	CCONJ
bptjm-71	183	43	dna	dna	NOUN
bptjm-71	183	44	damage	damage	NOUN
bptjm-71	183	45	by	by	ADP
bptjm-71	183	46	upregulating	upregulating	ADJ
bptjm-71	183	47	sirtuin-1	sirtuin-1	PROPN
bptjm-71	183	48	(	(	PUNCT
bptjm-71	183	49	sirt1	sirt1	NOUN
bptjm-71	183	50	)	)	PUNCT
bptjm-71	183	51	in	in	ADP
bptjm-71	183	52	a	a	DET
bptjm-71	183	53	dosage	dosage	NOUN
bptjm-71	183	54	-	-	PUNCT
bptjm-71	183	55	dependent	dependent	ADJ
bptjm-71	183	56	manner.23	manner.23	NOUN
bptjm-71	183	57	it	it	PRON
bptjm-71	183	58	also	also	ADV
bptjm-71	183	59	delayed	delay	VERB
bptjm-71	183	60	the	the	DET
bptjm-71	183	61	onset	onset	NOUN
bptjm-71	183	62	of	of	ADP
bptjm-71	183	63	senescence	senescence	NOUN
bptjm-71	183	64	in	in	ADP
bptjm-71	183	65	endothelial	endothelial	ADJ
bptjm-71	183	66	cells	cell	NOUN
bptjm-71	183	67	by	by	ADP
bptjm-71	183	68	increasing	increase	VERB
bptjm-71	183	69	nitric	nitric	ADJ
bptjm-71	183	70	oxide	oxide	NOUN
bptjm-71	183	71	synthesis	synthesis	NOUN
bptjm-71	183	72	and	and	CCONJ
bptjm-71	183	73	decreasing	decrease	VERB
bptjm-71	183	74	oxidative	oxidative	ADJ
bptjm-71	183	75	stress	stress	NOUN
bptjm-71	183	76	,	,	PUNCT
bptjm-71	183	77	subsequently	subsequently	ADV
bptjm-71	183	78	upregulating	upregulating	ADJ
bptjm-71	183	79	telomerase	telomerase	NOUN
bptjm-71	183	80	activity.69	activity.69	PROPN
bptjm-71	183	81	however	however	ADV
bptjm-71	183	82	,	,	PUNCT
bptjm-71	183	83	other	other	ADJ
bptjm-71	183	84	experimental	experimental	ADJ
bptjm-71	183	85	studies	study	NOUN
bptjm-71	183	86	indicate	indicate	VERB
bptjm-71	183	87	that	that	SCONJ
bptjm-71	183	88	the	the	DET
bptjm-71	183	89	effects	effect	NOUN
bptjm-71	183	90	of	of	ADP
bptjm-71	183	91	aspirin	aspirin	NOUN
bptjm-71	183	92	on	on	ADP
bptjm-71	183	93	senescence	senescence	NOUN
bptjm-71	183	94	vary	vary	VERB
bptjm-71	183	95	with	with	ADP
bptjm-71	183	96	context	context	NOUN
bptjm-71	183	97	,	,	PUNCT
bptjm-71	183	98	stress	stress	NOUN
bptjm-71	183	99	type	type	NOUN
bptjm-71	183	100	,	,	PUNCT
bptjm-71	183	101	and	and	CCONJ
bptjm-71	183	102	dosage.63	dosage.63	ADJ
bptjm-71	183	103	ethyl	ethyl	PROPN
bptjm-71	183	104	pyruvate	pyruvate	NOUN
bptjm-71	183	105	and	and	CCONJ
bptjm-71	183	106	glycyrrhizic	glycyrrhizic	NOUN
bptjm-71	183	107	acid	acid	PROPN
bptjm-71	183	108	ethyl	ethyl	PROPN
bptjm-71	183	109	pyruvate	pyruvate	NOUN
bptjm-71	183	110	and	and	CCONJ
bptjm-71	183	111	glycyrrhizic	glycyrrhizic	NOUN
bptjm-71	183	112	acid	acid	NOUN
bptjm-71	183	113	inhibit	inhibit	VERB
bptjm-71	183	114	the	the	DET
bptjm-71	183	115	release	release	NOUN
bptjm-71	183	116	of	of	ADP
bptjm-71	183	117	hmgb1	hmgb1	PROPN
bptjm-71	183	118	,	,	PUNCT
bptjm-71	183	119	and	and	CCONJ
bptjm-71	183	120	can	can	AUX
bptjm-71	183	121	also	also	ADV
bptjm-71	183	122	inhibit	inhibit	VERB
bptjm-71	183	123	p53	p53	NOUN
bptjm-71	183	124	aggregation	aggregation	NOUN
bptjm-71	183	125	and	and	CCONJ
bptjm-71	183	126	prevent	prevent	VERB
bptjm-71	183	127	tau	tau	PROPN
bptjm-71	183	128	phosphorylation.27,34this	phosphorylation.27,34this	PRON
bptjm-71	183	129	indicates	indicate	VERB
bptjm-71	183	130	that	that	SCONJ
bptjm-71	183	131	the	the	DET
bptjm-71	183	132	two	two	NUM
bptjm-71	183	133	drugs	drug	NOUN
bptjm-71	183	134	could	could	AUX
bptjm-71	183	135	have	have	VERB
bptjm-71	183	136	potential	potential	ADJ
bptjm-71	183	137	benefits	benefit	NOUN
bptjm-71	183	138	in	in	ADP
bptjm-71	183	139	treating	treat	VERB
bptjm-71	183	140	alzheimer	alzheimer	NOUN
bptjm-71	183	141	’s	’s	PART
bptjm-71	183	142	.	.	PUNCT
bptjm-71	184	1	other	other	ADJ
bptjm-71	184	2	areas	area	NOUN
bptjm-71	184	3	that	that	PRON
bptjm-71	184	4	are	be	AUX
bptjm-71	184	5	only	only	ADV
bptjm-71	184	6	just	just	ADV
bptjm-71	184	7	being	be	AUX
bptjm-71	184	8	explored	explore	VERB
bptjm-71	184	9	include	include	VERB
bptjm-71	184	10	nf	nf	ADJ
bptjm-71	184	11	-	-	PUNCT
bptjm-71	184	12	κb	κb	NOUN
bptjm-71	184	13	inhibition	inhibition	NOUN
bptjm-71	184	14	,	,	PUNCT
bptjm-71	184	15	p38	p38	NOUN
bptjm-71	184	16	mapk	mapk	NOUN
bptjm-71	184	17	inhibition	inhibition	NOUN
bptjm-71	184	18	,	,	PUNCT
bptjm-71	184	19	the	the	DET
bptjm-71	184	20	janus	janus	PROPN
bptjm-71	184	21	kinase	kinase	PROPN
bptjm-71	184	22	/	/	SYM
bptjm-71	184	23	signal	signal	NOUN
bptjm-71	184	24	transducer	transducer	NOUN
bptjm-71	184	25	signaling	signal	VERB
bptjm-71	184	26	pathway	pathway	NOUN
bptjm-71	184	27	,	,	PUNCT
bptjm-71	184	28	mutated	mutate	VERB
bptjm-71	184	29	ataxia	ataxia	NOUN
bptjm-71	184	30	telangiectasia	telangiectasia	NOUN
bptjm-71	184	31	inhibitors	inhibitor	NOUN
bptjm-71	184	32	,	,	PUNCT
bptjm-71	184	33	and	and	CCONJ
bptjm-71	184	34	statins.63	statins.63	ADJ
bptjm-71	184	35	overall	overall	ADJ
bptjm-71	184	36	,	,	PUNCT
bptjm-71	184	37	senomorphic	senomorphic	ADJ
bptjm-71	184	38	medications	medication	NOUN
bptjm-71	184	39	are	be	AUX
bptjm-71	184	40	a	a	DET
bptjm-71	184	41	very	very	ADV
bptjm-71	184	42	promising	promising	ADJ
bptjm-71	184	43	area	area	NOUN
bptjm-71	184	44	of	of	ADP
bptjm-71	184	45	research	research	NOUN
bptjm-71	184	46	for	for	ADP
bptjm-71	184	47	treatment	treatment	NOUN
bptjm-71	184	48	of	of	ADP
bptjm-71	184	49	neurodegenerative	neurodegenerative	ADJ
bptjm-71	184	50	diseases	disease	NOUN
bptjm-71	184	51	,	,	PUNCT
bptjm-71	184	52	but	but	CCONJ
bptjm-71	184	53	there	there	PRON
bptjm-71	184	54	is	be	VERB
bptjm-71	184	55	still	still	ADV
bptjm-71	184	56	a	a	DET
bptjm-71	184	57	lot	lot	NOUN
bptjm-71	184	58	of	of	ADP
bptjm-71	184	59	work	work	NOUN
bptjm-71	184	60	to	to	PART
bptjm-71	184	61	be	be	AUX
bptjm-71	184	62	done	do	VERB
bptjm-71	184	63	and	and	CCONJ
bptjm-71	184	64	discoveries	discovery	NOUN
bptjm-71	184	65	to	to	PART
bptjm-71	184	66	be	be	AUX
bptjm-71	184	67	made	make	VERB
bptjm-71	184	68	.	.	PUNCT
bptjm-71	185	1	berkeley	berkeley	PROPN
bptjm-71	185	2	pharma	pharma	PROPN
bptjm-71	185	3	tech	tech	PROPN
bptjm-71	185	4	journal	journal	NOUN
bptjm-71	185	5	of	of	ADP
bptjm-71	185	6	medicine	medicine	NOUN
bptjm-71	185	7	|	|	ADV
bptjm-71	185	8	63	63	NUM
bptjm-71	185	9	2.3	2.3	NUM
bptjm-71	185	10	.	.	PUNCT
bptjm-71	186	1	mitochondria	mitochondria	NOUN
bptjm-71	186	2	-	-	PUNCT
bptjm-71	186	3	based	base	VERB
bptjm-71	186	4	therapies	therapy	NOUN
bptjm-71	186	5	mitochondria	mitochondria	NOUN
bptjm-71	186	6	are	be	AUX
bptjm-71	186	7	the	the	DET
bptjm-71	186	8	dominant	dominant	ADJ
bptjm-71	186	9	sources	source	NOUN
bptjm-71	186	10	of	of	ADP
bptjm-71	186	11	reactive	reactive	ADJ
bptjm-71	186	12	oxygen	oxygen	NOUN
bptjm-71	186	13	species	specie	NOUN
bptjm-71	186	14	(	(	PUNCT
bptjm-71	186	15	ros	ros	PROPN
bptjm-71	186	16	)	)	PUNCT
bptjm-71	186	17	,	,	PUNCT
bptjm-71	186	18	which	which	PRON
bptjm-71	186	19	is	be	AUX
bptjm-71	186	20	produced	produce	VERB
bptjm-71	186	21	as	as	ADP
bptjm-71	186	22	a	a	DET
bptjm-71	186	23	by	by	ADP
bptjm-71	186	24	-	-	PUNCT
bptjm-71	186	25	product	product	NOUN
bptjm-71	186	26	of	of	ADP
bptjm-71	186	27	the	the	DET
bptjm-71	186	28	electron	electron	NOUN
bptjm-71	186	29	transport	transport	NOUN
bptjm-71	186	30	chain	chain	NOUN
bptjm-71	186	31	in	in	ADP
bptjm-71	186	32	mitochondria	mitochondria	PROPN
bptjm-71	186	33	.	.	PUNCT
bptjm-71	187	1	under	under	ADP
bptjm-71	187	2	normal	normal	ADJ
bptjm-71	187	3	conditions	condition	NOUN
bptjm-71	187	4	,	,	PUNCT
bptjm-71	187	5	ros	ros	PROPN
bptjm-71	187	6	is	be	AUX
bptjm-71	187	7	central	central	ADJ
bptjm-71	187	8	for	for	ADP
bptjm-71	187	9	organismal	organismal	ADJ
bptjm-71	187	10	homeostasis	homeostasis	NOUN
bptjm-71	187	11	,	,	PUNCT
bptjm-71	187	12	able	able	ADJ
bptjm-71	187	13	to	to	PART
bptjm-71	187	14	promote	promote	VERB
bptjm-71	187	15	necessary	necessary	ADJ
bptjm-71	187	16	signal	signal	NOUN
bptjm-71	187	17	transduction	transduction	NOUN
bptjm-71	187	18	by	by	ADP
bptjm-71	187	19	mediating	mediate	VERB
bptjm-71	187	20	redox	redox	ADJ
bptjm-71	187	21	modifications	modification	NOUN
bptjm-71	187	22	of	of	ADP
bptjm-71	187	23	specific	specific	ADJ
bptjm-71	187	24	molecules	molecule	NOUN
bptjm-71	187	25	;	;	PUNCT
bptjm-71	187	26	however	however	ADV
bptjm-71	187	27	,	,	PUNCT
bptjm-71	187	28	damaged	damaged	ADJ
bptjm-71	187	29	mitochondria	mitochondria	NOUN
bptjm-71	187	30	often	often	ADV
bptjm-71	187	31	result	result	VERB
bptjm-71	187	32	in	in	ADP
bptjm-71	187	33	an	an	DET
bptjm-71	187	34	overproduction	overproduction	NOUN
bptjm-71	187	35	of	of	ADP
bptjm-71	187	36	this	this	DET
bptjm-71	187	37	superoxide	superoxide	NOUN
bptjm-71	187	38	,	,	PUNCT
bptjm-71	187	39	leading	lead	VERB
bptjm-71	187	40	to	to	ADP
bptjm-71	187	41	oxidative	oxidative	ADJ
bptjm-71	187	42	stress	stress	NOUN
bptjm-71	187	43	,	,	PUNCT
bptjm-71	187	44	another	another	DET
bptjm-71	187	45	leading	leading	ADJ
bptjm-71	187	46	factor	factor	NOUN
bptjm-71	187	47	of	of	ADP
bptjm-71	187	48	cellular	cellular	ADJ
bptjm-71	187	49	senescence	senescence	NOUN
bptjm-71	187	50	.	.	PUNCT
bptjm-71	188	1	imbalances	imbalance	NOUN
bptjm-71	188	2	between	between	ADP
bptjm-71	188	3	ros	ros	PROPN
bptjm-71	188	4	production	production	NOUN
bptjm-71	188	5	and	and	CCONJ
bptjm-71	188	6	detoxification	detoxification	NOUN
bptjm-71	188	7	of	of	ADP
bptjm-71	188	8	these	these	DET
bptjm-71	188	9	reactive	reactive	ADJ
bptjm-71	188	10	species	specie	NOUN
bptjm-71	188	11	,	,	PUNCT
bptjm-71	188	12	or	or	CCONJ
bptjm-71	188	13	antioxidant	antioxidant	ADJ
bptjm-71	188	14	activity	activity	NOUN
bptjm-71	188	15	,	,	PUNCT
bptjm-71	188	16	is	be	AUX
bptjm-71	188	17	toxic	toxic	ADJ
bptjm-71	188	18	to	to	ADP
bptjm-71	188	19	cells	cell	NOUN
bptjm-71	188	20	.	.	PUNCT
bptjm-71	189	1	it	it	PRON
bptjm-71	189	2	activates	activate	VERB
bptjm-71	189	3	p53	p53	NOUN
bptjm-71	189	4	,	,	PUNCT
bptjm-71	189	5	which	which	PRON
bptjm-71	189	6	induces	induce	VERB
bptjm-71	189	7	the	the	DET
bptjm-71	189	8	cyclin	cyclin	NOUN
bptjm-71	189	9	-	-	PUNCT
bptjm-71	189	10	dependent	dependent	ADJ
bptjm-71	189	11	kinase	kinase	NOUN
bptjm-71	189	12	(	(	PUNCT
bptjm-71	189	13	cdk	cdk	PROPN
bptjm-71	189	14	)	)	PUNCT
bptjm-71	189	15	inhibitor	inhibitor	NOUN
bptjm-71	189	16	p21	p21	NOUN
bptjm-71	189	17	,	,	PUNCT
bptjm-71	189	18	causing	cause	VERB
bptjm-71	189	19	cell	cell	NOUN
bptjm-71	189	20	cycle	cycle	NOUN
bptjm-71	189	21	arrest	arrest	NOUN
bptjm-71	189	22	and	and	CCONJ
bptjm-71	189	23	senescence	senescence	NOUN
bptjm-71	189	24	.	.	PUNCT
bptjm-71	190	1	in	in	ADP
bptjm-71	190	2	addition	addition	NOUN
bptjm-71	190	3	,	,	PUNCT
bptjm-71	190	4	elevated	elevated	ADJ
bptjm-71	190	5	ros	ros	PROPN
bptjm-71	190	6	levels	level	NOUN
bptjm-71	190	7	have	have	AUX
bptjm-71	190	8	also	also	ADV
bptjm-71	190	9	been	be	AUX
bptjm-71	190	10	found	find	VERB
bptjm-71	190	11	to	to	PART
bptjm-71	190	12	be	be	AUX
bptjm-71	190	13	strong	strong	ADJ
bptjm-71	190	14	modulators	modulator	NOUN
bptjm-71	190	15	of	of	ADP
bptjm-71	190	16	inflammatory	inflammatory	ADJ
bptjm-71	190	17	pathways	pathway	NOUN
bptjm-71	190	18	that	that	PRON
bptjm-71	190	19	can	can	AUX
bptjm-71	190	20	accelerate	accelerate	VERB
bptjm-71	190	21	cellular	cellular	ADJ
bptjm-71	190	22	senescence	senescence	NOUN
bptjm-71	190	23	and	and	CCONJ
bptjm-71	190	24	further	far	ADV
bptjm-71	190	25	aggravate	aggravate	VERB
bptjm-71	190	26	inflammaging	inflammage	VERB
bptjm-71	190	27	.	.	PUNCT
bptjm-71	191	1	as	as	ADP
bptjm-71	191	2	a	a	DET
bptjm-71	191	3	result	result	NOUN
bptjm-71	191	4	,	,	PUNCT
bptjm-71	191	5	dysfunctional	dysfunctional	ADJ
bptjm-71	191	6	mitochondria	mitochondria	NOUN
bptjm-71	191	7	have	have	AUX
bptjm-71	191	8	become	become	VERB
bptjm-71	191	9	a	a	DET
bptjm-71	191	10	hallmark	hallmark	NOUN
bptjm-71	191	11	of	of	ADP
bptjm-71	191	12	and	and	CCONJ
bptjm-71	191	13	contributor	contributor	NOUN
bptjm-71	191	14	to	to	ADP
bptjm-71	191	15	aging	age	VERB
bptjm-71	191	16	and	and	CCONJ
bptjm-71	191	17	aging	age	VERB
bptjm-71	191	18	-	-	PUNCT
bptjm-71	191	19	related	relate	VERB
bptjm-71	191	20	neurodegeneration	neurodegeneration	NOUN
bptjm-71	191	21	.	.	PUNCT
bptjm-71	192	1	while	while	SCONJ
bptjm-71	192	2	the	the	DET
bptjm-71	192	3	role	role	NOUN
bptjm-71	192	4	of	of	ADP
bptjm-71	192	5	dysfunctional	dysfunctional	ADJ
bptjm-71	192	6	mitochondria	mitochondria	NOUN
bptjm-71	192	7	in	in	ADP
bptjm-71	192	8	aging	age	VERB
bptjm-71	192	9	and	and	CCONJ
bptjm-71	192	10	cellular	cellular	ADJ
bptjm-71	192	11	senescence	senescence	NOUN
bptjm-71	192	12	is	be	AUX
bptjm-71	192	13	still	still	ADV
bptjm-71	192	14	being	be	AUX
bptjm-71	192	15	explored	explore	VERB
bptjm-71	192	16	,	,	PUNCT
bptjm-71	192	17	many	many	ADJ
bptjm-71	192	18	studies	study	NOUN
bptjm-71	192	19	show	show	VERB
bptjm-71	192	20	that	that	SCONJ
bptjm-71	192	21	therapies	therapy	NOUN
bptjm-71	192	22	targeting	target	VERB
bptjm-71	192	23	these	these	DET
bptjm-71	192	24	defects	defect	NOUN
bptjm-71	192	25	have	have	AUX
bptjm-71	192	26	been	be	AUX
bptjm-71	192	27	effective	effective	ADJ
bptjm-71	192	28	in	in	ADP
bptjm-71	192	29	alleviating	alleviate	VERB
bptjm-71	192	30	senescence	senescence	NOUN
bptjm-71	192	31	-	-	PUNCT
bptjm-71	192	32	associated	associate	VERB
bptjm-71	192	33	symptoms.7	symptoms.7	NOUN
bptjm-71	192	34	nad+	nad+	PROPN
bptjm-71	192	35	supplementation	supplementation	NOUN
bptjm-71	192	36	nad+	nad+	PROPN
bptjm-71	192	37	supplementation	supplementation	NOUN
bptjm-71	192	38	has	have	AUX
bptjm-71	192	39	rapidly	rapidly	ADV
bptjm-71	192	40	become	become	VERB
bptjm-71	192	41	a	a	DET
bptjm-71	192	42	popular	popular	ADJ
bptjm-71	192	43	research	research	NOUN
bptjm-71	192	44	avenue	avenue	NOUN
bptjm-71	192	45	as	as	ADP
bptjm-71	192	46	a	a	DET
bptjm-71	192	47	potential	potential	ADJ
bptjm-71	192	48	therapy	therapy	NOUN
bptjm-71	192	49	for	for	ADP
bptjm-71	192	50	neurodegenerative	neurodegenerative	ADJ
bptjm-71	192	51	diseases	disease	NOUN
bptjm-71	192	52	with	with	ADP
bptjm-71	192	53	underlying	underlie	VERB
bptjm-71	192	54	mitochondrial	mitochondrial	ADJ
bptjm-71	192	55	dysfunction	dysfunction	NOUN
bptjm-71	192	56	-	-	PUNCT
bptjm-71	192	57	induced	induce	VERB
bptjm-71	192	58	senescence	senescence	NOUN
bptjm-71	192	59	causes	cause	NOUN
bptjm-71	192	60	.	.	PUNCT
bptjm-71	193	1	studies	study	NOUN
bptjm-71	193	2	have	have	AUX
bptjm-71	193	3	shown	show	VERB
bptjm-71	193	4	that	that	SCONJ
bptjm-71	193	5	nadh	nadh	NOUN
bptjm-71	193	6	improves	improve	VERB
bptjm-71	193	7	motor	motor	NOUN
bptjm-71	193	8	symptoms	symptom	NOUN
bptjm-71	193	9	in	in	ADP
bptjm-71	193	10	parkinson	parkinson	NOUN
bptjm-71	193	11	's	's	PART
bptjm-71	193	12	disease	disease	NOUN
bptjm-71	193	13	and	and	CCONJ
bptjm-71	193	14	nad+	nad+	PROPN
bptjm-71	193	15	supplementation	supplementation	NOUN
bptjm-71	193	16	can	can	AUX
bptjm-71	193	17	prevent	prevent	VERB
bptjm-71	193	18	sting	sting	ADJ
bptjm-71	193	19	-	-	PUNCT
bptjm-71	193	20	induced	induce	VERB
bptjm-71	193	21	senescence	senescence	NOUN
bptjm-71	193	22	in	in	ADP
bptjm-71	193	23	a	a	DET
bptjm-71	193	24	-	-	PUNCT
bptjm-71	193	25	t	t	NOUN
bptjm-71	193	26	cells	cell	NOUN
bptjm-71	193	27	and	and	CCONJ
bptjm-71	193	28	mice	mouse	NOUN
bptjm-71	193	29	,	,	PUNCT
bptjm-71	193	30	while	while	SCONJ
bptjm-71	193	31	promoting	promote	VERB
bptjm-71	193	32	mitophagy	mitophagy	NOUN
bptjm-71	193	33	to	to	PART
bptjm-71	193	34	remove	remove	VERB
bptjm-71	193	35	damaged	damage	VERB
bptjm-71	193	36	mitochondria	mitochondria	NOUN
bptjm-71	193	37	and	and	CCONJ
bptjm-71	193	38	prevent	prevent	VERB
bptjm-71	193	39	senescence	senescence	NOUN
bptjm-71	193	40	and	and	CCONJ
bptjm-71	193	41	neuroinflammation.70,71	neuroinflammation.70,71	NOUN
bptjm-71	193	42	additionally	additionally	ADV
bptjm-71	193	43	,	,	PUNCT
bptjm-71	193	44	the	the	DET
bptjm-71	193	45	cgas	cgas	ADV
bptjm-71	193	46	-	-	PUNCT
bptjm-71	193	47	sting	ste	VERB
bptjm-71	193	48	pathway	pathway	NOUN
bptjm-71	193	49	has	have	AUX
bptjm-71	193	50	been	be	AUX
bptjm-71	193	51	implicated	implicate	VERB
bptjm-71	193	52	in	in	ADP
bptjm-71	193	53	attenuating	attenuate	VERB
bptjm-71	193	54	neuroinflammation	neuroinflammation	NOUN
bptjm-71	193	55	,	,	PUNCT
bptjm-71	193	56	suggesting	suggest	VERB
bptjm-71	193	57	that	that	SCONJ
bptjm-71	193	58	boosting	boost	VERB
bptjm-71	193	59	nad+	nad+	NOUN
bptjm-71	193	60	with	with	ADP
bptjm-71	193	61	nicotinamide	nicotinamide	NOUN
bptjm-71	193	62	riboside	riboside	NOUN
bptjm-71	193	63	(	(	PUNCT
bptjm-71	193	64	nr	nr	NOUN
bptjm-71	193	65	)	)	PUNCT
bptjm-71	193	66	treatment	treatment	NOUN
bptjm-71	193	67	could	could	AUX
bptjm-71	193	68	serve	serve	VERB
bptjm-71	193	69	as	as	ADP
bptjm-71	193	70	a	a	DET
bptjm-71	193	71	therapeutic	therapeutic	ADJ
bptjm-71	193	72	approach	approach	NOUN
bptjm-71	193	73	to	to	PART
bptjm-71	193	74	mitigate	mitigate	VERB
bptjm-71	193	75	neurodegeneration.72	neurodegeneration.72	NOUN
bptjm-71	193	76	these	these	DET
bptjm-71	193	77	findings	finding	NOUN
bptjm-71	193	78	highlight	highlight	VERB
bptjm-71	193	79	the	the	DET
bptjm-71	193	80	potential	potential	NOUN
bptjm-71	193	81	of	of	ADP
bptjm-71	193	82	nad+	nad+	PROPN
bptjm-71	193	83	as	as	ADP
bptjm-71	193	84	a	a	DET
bptjm-71	193	85	therapeutic	therapeutic	ADJ
bptjm-71	193	86	strategy	strategy	NOUN
bptjm-71	193	87	for	for	ADP
bptjm-71	193	88	addressing	address	VERB
bptjm-71	193	89	senescence	senescence	NOUN
bptjm-71	193	90	-	-	PUNCT
bptjm-71	193	91	related	relate	VERB
bptjm-71	193	92	issues	issue	NOUN
bptjm-71	193	93	in	in	ADP
bptjm-71	193	94	neurodegenerative	neurodegenerative	ADJ
bptjm-71	193	95	diseases	disease	NOUN
bptjm-71	193	96	.	.	PUNCT
bptjm-71	194	1	berkeley	berkeley	PROPN
bptjm-71	194	2	pharma	pharma	PROPN
bptjm-71	194	3	tech	tech	PROPN
bptjm-71	194	4	journal	journal	NOUN
bptjm-71	194	5	of	of	ADP
bptjm-71	194	6	medicine	medicine	NOUN
bptjm-71	194	7	|	|	ADP
bptjm-71	194	8	64	64	NUM
bptjm-71	194	9	limitations	limitation	NOUN
bptjm-71	194	10	studies	study	NOUN
bptjm-71	194	11	have	have	AUX
bptjm-71	194	12	shown	show	VERB
bptjm-71	194	13	that	that	PRON
bptjm-71	194	14	increased	increase	VERB
bptjm-71	194	15	nad+	nad+	PROPN
bptjm-71	194	16	levels	level	NOUN
bptjm-71	194	17	could	could	AUX
bptjm-71	194	18	lead	lead	VERB
bptjm-71	194	19	to	to	ADP
bptjm-71	194	20	the	the	DET
bptjm-71	194	21	accumulation	accumulation	NOUN
bptjm-71	194	22	of	of	ADP
bptjm-71	194	23	potential	potential	ADJ
bptjm-71	194	24	toxic	toxic	ADJ
bptjm-71	194	25	metabolites	metabolite	NOUN
bptjm-71	194	26	and	and	CCONJ
bptjm-71	194	27	may	may	AUX
bptjm-71	194	28	even	even	ADV
bptjm-71	194	29	contribute	contribute	VERB
bptjm-71	194	30	to	to	ADP
bptjm-71	194	31	tumorigenesis.70	tumorigenesis.70	PRON
bptjm-71	194	32	additionally	additionally	ADV
bptjm-71	194	33	,	,	PUNCT
bptjm-71	194	34	excessive	excessive	ADJ
bptjm-71	194	35	nad+	nad+	PROPN
bptjm-71	194	36	supplementation	supplementation	NOUN
bptjm-71	194	37	in	in	ADP
bptjm-71	194	38	young	young	ADJ
bptjm-71	194	39	healthy	healthy	ADJ
bptjm-71	194	40	mice	mouse	NOUN
bptjm-71	194	41	,	,	PUNCT
bptjm-71	194	42	which	which	PRON
bptjm-71	194	43	already	already	ADV
bptjm-71	194	44	have	have	VERB
bptjm-71	194	45	sufficient	sufficient	ADJ
bptjm-71	194	46	nad+	nad+	NOUN
bptjm-71	194	47	levels	level	NOUN
bptjm-71	194	48	,	,	PUNCT
bptjm-71	194	49	has	have	AUX
bptjm-71	194	50	been	be	AUX
bptjm-71	194	51	linked	link	VERB
bptjm-71	194	52	to	to	ADP
bptjm-71	194	53	elevated	elevated	ADJ
bptjm-71	194	54	levels	level	NOUN
bptjm-71	194	55	of	of	ADP
bptjm-71	194	56	pro	pro	ADJ
bptjm-71	194	57	-	-	ADJ
bptjm-71	194	58	inflammatory	inflammatory	ADJ
bptjm-71	194	59	cytokines	cytokine	NOUN
bptjm-71	194	60	such	such	ADJ
bptjm-71	194	61	as	as	ADP
bptjm-71	194	62	il1β	il1β	PROPN
bptjm-71	194	63	and	and	CCONJ
bptjm-71	194	64	il6	il6	PROPN
bptjm-71	194	65	,	,	PUNCT
bptjm-71	194	66	suggesting	suggest	VERB
bptjm-71	194	67	unintended	unintended	ADJ
bptjm-71	194	68	consequences	consequence	NOUN
bptjm-71	194	69	on	on	ADP
bptjm-71	194	70	inflammatory	inflammatory	ADJ
bptjm-71	194	71	pathways.71	pathways.71	NOUN
bptjm-71	194	72	these	these	DET
bptjm-71	194	73	findings	finding	NOUN
bptjm-71	194	74	highlight	highlight	VERB
bptjm-71	194	75	the	the	DET
bptjm-71	194	76	need	need	NOUN
bptjm-71	194	77	for	for	ADP
bptjm-71	194	78	cautious	cautious	ADJ
bptjm-71	194	79	consideration	consideration	NOUN
bptjm-71	194	80	of	of	ADP
bptjm-71	194	81	nad+	nad+	PROPN
bptjm-71	194	82	supplementation	supplementation	NOUN
bptjm-71	194	83	as	as	ADP
bptjm-71	194	84	a	a	DET
bptjm-71	194	85	therapeutic	therapeutic	ADJ
bptjm-71	194	86	approach	approach	NOUN
bptjm-71	194	87	,	,	PUNCT
bptjm-71	194	88	with	with	SCONJ
bptjm-71	194	89	attention	attention	NOUN
bptjm-71	194	90	to	to	ADP
bptjm-71	194	91	dosage	dosage	NOUN
bptjm-71	194	92	and	and	CCONJ
bptjm-71	194	93	potential	potential	ADJ
bptjm-71	194	94	age	age	NOUN
bptjm-71	194	95	-	-	PUNCT
bptjm-71	194	96	related	relate	VERB
bptjm-71	194	97	variations	variation	NOUN
bptjm-71	194	98	to	to	PART
bptjm-71	194	99	avoid	avoid	VERB
bptjm-71	194	100	adverse	adverse	ADJ
bptjm-71	194	101	effects	effect	NOUN
bptjm-71	194	102	.	.	PUNCT
bptjm-71	195	1	further	further	ADJ
bptjm-71	195	2	research	research	NOUN
bptjm-71	195	3	is	be	AUX
bptjm-71	195	4	necessary	necessary	ADJ
bptjm-71	195	5	to	to	PART
bptjm-71	195	6	fully	fully	ADV
bptjm-71	195	7	understand	understand	VERB
bptjm-71	195	8	the	the	DET
bptjm-71	195	9	risks	risk	NOUN
bptjm-71	195	10	and	and	CCONJ
bptjm-71	195	11	benefits	benefit	NOUN
bptjm-71	195	12	of	of	ADP
bptjm-71	195	13	nad+	nad+	PROPN
bptjm-71	195	14	supplementation	supplementation	NOUN
bptjm-71	195	15	as	as	ADP
bptjm-71	195	16	a	a	DET
bptjm-71	195	17	therapy	therapy	NOUN
bptjm-71	195	18	for	for	ADP
bptjm-71	195	19	senescence	senescence	NOUN
bptjm-71	195	20	and	and	CCONJ
bptjm-71	195	21	neurodegenerative	neurodegenerative	ADJ
bptjm-71	195	22	diseases	disease	NOUN
bptjm-71	195	23	.	.	PUNCT
bptjm-71	196	1	mapks	mapks	NOUN
bptjm-71	196	2	mitogen	mitogen	NOUN
bptjm-71	196	3	-	-	PUNCT
bptjm-71	196	4	activated	activate	VERB
bptjm-71	196	5	protein	protein	NOUN
bptjm-71	196	6	kinase	kinase	NOUN
bptjm-71	196	7	15	15	NUM
bptjm-71	196	8	(	(	PUNCT
bptjm-71	196	9	mapk15	mapk15	ADJ
bptjm-71	196	10	)	)	PUNCT
bptjm-71	196	11	is	be	AUX
bptjm-71	196	12	another	another	DET
bptjm-71	196	13	potential	potential	ADJ
bptjm-71	196	14	target	target	NOUN
bptjm-71	196	15	of	of	ADP
bptjm-71	196	16	mitochondria	mitochondria	NOUN
bptjm-71	196	17	-	-	PUNCT
bptjm-71	196	18	based	base	VERB
bptjm-71	196	19	therapies	therapy	NOUN
bptjm-71	196	20	.	.	PUNCT
bptjm-71	197	1	mapk15	mapk15	PROPN
bptjm-71	197	2	,	,	PUNCT
bptjm-71	197	3	an	an	DET
bptjm-71	197	4	atypical	atypical	ADJ
bptjm-71	197	5	mitogen	mitogen	NOUN
bptjm-71	197	6	-	-	PUNCT
bptjm-71	197	7	activated	activate	VERB
bptjm-71	197	8	protein	protein	NOUN
bptjm-71	197	9	(	(	PUNCT
bptjm-71	197	10	map	map	NOUN
bptjm-71	197	11	)	)	PUNCT
bptjm-71	197	12	kinase	kinase	PROPN
bptjm-71	197	13	,	,	PUNCT
bptjm-71	197	14	has	have	AUX
bptjm-71	197	15	been	be	AUX
bptjm-71	197	16	found	find	VERB
bptjm-71	197	17	to	to	PART
bptjm-71	197	18	control	control	VERB
bptjm-71	197	19	the	the	DET
bptjm-71	197	20	mitophagic	mitophagic	NOUN
bptjm-71	197	21	process	process	NOUN
bptjm-71	197	22	by	by	ADP
bptjm-71	197	23	stimulating	stimulate	VERB
bptjm-71	197	24	phosphorylation	phosphorylation	NOUN
bptjm-71	197	25	of	of	ADP
bptjm-71	197	26	unc-51	unc-51	NOUN
bptjm-71	197	27	like	like	ADP
bptjm-71	197	28	autophagy	autophagy	NOUN
bptjm-71	197	29	activating	activate	VERB
bptjm-71	197	30	kinase	kinase	PROPN
bptjm-71	197	31	1	1	NUM
bptjm-71	197	32	(	(	PUNCT
bptjm-71	197	33	ulk1)-dependent	ulk1)-dependent	NOUN
bptjm-71	197	34	parkin	parkin	NOUN
bptjm-71	197	35	rbr	rbr	VERB
bptjm-71	197	36	e3	e3	NOUN
bptjm-71	197	37	ubiquitin	ubiquitin	ADJ
bptjm-71	197	38	protein	protein	NOUN
bptjm-71	197	39	ligase	ligase	NOUN
bptjm-71	197	40	(	(	PUNCT
bptjm-71	197	41	prkn	prkn	NOUN
bptjm-71	197	42	)	)	PUNCT
bptjm-71	197	43	ser108	ser108	PROPN
bptjm-71	197	44	,	,	PUNCT
bptjm-71	197	45	which	which	PRON
bptjm-71	197	46	induces	induce	VERB
bptjm-71	197	47	recruitment	recruitment	NOUN
bptjm-71	197	48	of	of	ADP
bptjm-71	197	49	damaged	damage	VERB
bptjm-71	197	50	mitochondria	mitochondria	NOUN
bptjm-71	197	51	to	to	ADP
bptjm-71	197	52	lysosomal	lysosomal	ADJ
bptjm-71	197	53	compartments	compartment	NOUN
bptjm-71	197	54	for	for	ADP
bptjm-71	197	55	disposal	disposal	NOUN
bptjm-71	197	56	.	.	PUNCT
bptjm-71	198	1	as	as	ADP
bptjm-71	198	2	such	such	ADJ
bptjm-71	198	3	,	,	PUNCT
bptjm-71	198	4	by	by	ADP
bptjm-71	198	5	effectively	effectively	ADV
bptjm-71	198	6	getting	getting	AUX
bptjm-71	198	7	rid	rid	VERB
bptjm-71	198	8	of	of	ADP
bptjm-71	198	9	defective	defective	ADJ
bptjm-71	198	10	mitochondria	mitochondria	NOUN
bptjm-71	198	11	,	,	PUNCT
bptjm-71	198	12	mapk15	mapk15	X
bptjm-71	198	13	helps	helps	AUX
bptjm-71	198	14	prevent	prevent	VERB
bptjm-71	198	15	oxidative	oxidative	ADJ
bptjm-71	198	16	stress	stress	NOUN
bptjm-71	198	17	and	and	CCONJ
bptjm-71	198	18	dna	dna	NOUN
bptjm-71	198	19	damage	damage	NOUN
bptjm-71	198	20	accumulation	accumulation	NOUN
bptjm-71	198	21	,	,	PUNCT
bptjm-71	198	22	both	both	PRON
bptjm-71	198	23	of	of	ADP
bptjm-71	198	24	which	which	PRON
bptjm-71	198	25	are	be	AUX
bptjm-71	198	26	effective	effective	ADJ
bptjm-71	198	27	in	in	ADP
bptjm-71	198	28	inducing	induce	VERB
bptjm-71	198	29	senescence	senescence	NOUN
bptjm-71	198	30	.	.	PUNCT
bptjm-71	199	1	in	in	ADP
bptjm-71	199	2	a	a	DET
bptjm-71	199	3	study	study	NOUN
bptjm-71	199	4	conducted	conduct	VERB
bptjm-71	199	5	with	with	ADP
bptjm-71	199	6	human	human	ADJ
bptjm-71	199	7	airway	airway	NOUN
bptjm-71	199	8	epithelial	epithelial	ADJ
bptjm-71	199	9	cells	cell	NOUN
bptjm-71	199	10	,	,	PUNCT
bptjm-71	199	11	it	it	PRON
bptjm-71	199	12	was	be	AUX
bptjm-71	199	13	found	find	VERB
bptjm-71	199	14	that	that	SCONJ
bptjm-71	199	15	the	the	DET
bptjm-71	199	16	downregulation	downregulation	NOUN
bptjm-71	199	17	of	of	ADP
bptjm-71	199	18	mapk15	mapk15	NOUN
bptjm-71	199	19	resulted	result	VERB
bptjm-71	199	20	in	in	ADP
bptjm-71	199	21	reduced	reduce	VERB
bptjm-71	199	22	cell	cell	NOUN
bptjm-71	199	23	proliferation	proliferation	NOUN
bptjm-71	199	24	,	,	PUNCT
bptjm-71	199	25	increased	increase	VERB
bptjm-71	199	26	p21	p21	NOUN
bptjm-71	199	27	levels	level	NOUN
bptjm-71	199	28	,	,	PUNCT
bptjm-71	199	29	increased	increase	VERB
bptjm-71	199	30	sa	sa	PROPN
bptjm-71	199	31	-	-	PUNCT
bptjm-71	199	32	β	β	NOUN
bptjm-71	199	33	-	-	ADJ
bptjm-71	199	34	gal	gal	ADJ
bptjm-71	199	35	activity	activity	NOUN
bptjm-71	199	36	,	,	PUNCT
bptjm-71	199	37	and	and	CCONJ
bptjm-71	199	38	increased	increase	VERB
bptjm-71	199	39	expression	expression	NOUN
bptjm-71	199	40	of	of	ADP
bptjm-71	199	41	sasp	sasp	NOUN
bptjm-71	199	42	cytokines	cytokine	NOUN
bptjm-71	199	43	,	,	PUNCT
bptjm-71	199	44	all	all	PRON
bptjm-71	199	45	of	of	ADP
bptjm-71	199	46	which	which	PRON
bptjm-71	199	47	are	be	AUX
bptjm-71	199	48	associated	associate	VERB
bptjm-71	199	49	with	with	ADP
bptjm-71	199	50	senescence.73	senescence.73	NOUN
bptjm-71	199	51	the	the	DET
bptjm-71	199	52	usefulness	usefulness	NOUN
bptjm-71	199	53	of	of	ADP
bptjm-71	199	54	other	other	ADJ
bptjm-71	199	55	members	member	NOUN
bptjm-71	199	56	of	of	ADP
bptjm-71	199	57	the	the	DET
bptjm-71	199	58	map	map	NOUN
bptjm-71	199	59	kinase	kinase	PROPN
bptjm-71	199	60	family	family	PROPN
bptjm-71	199	61	is	be	AUX
bptjm-71	199	62	still	still	ADV
bptjm-71	199	63	being	be	AUX
bptjm-71	199	64	investigated	investigate	VERB
bptjm-71	199	65	as	as	SCONJ
bptjm-71	199	66	they	they	PRON
bptjm-71	199	67	have	have	VERB
bptjm-71	199	68	a	a	DET
bptjm-71	199	69	duality	duality	NOUN
bptjm-71	199	70	that	that	PRON
bptjm-71	199	71	both	both	PRON
bptjm-71	199	72	helps	help	VERB
bptjm-71	199	73	prevent	prevent	VERB
bptjm-71	199	74	and	and	CCONJ
bptjm-71	199	75	promote	promote	VERB
bptjm-71	199	76	the	the	DET
bptjm-71	199	77	negative	negative	ADJ
bptjm-71	199	78	effects	effect	NOUN
bptjm-71	199	79	of	of	ADP
bptjm-71	199	80	senescence	senescence	NOUN
bptjm-71	199	81	.	.	PUNCT
bptjm-71	200	1	the	the	DET
bptjm-71	200	2	activation	activation	NOUN
bptjm-71	200	3	of	of	ADP
bptjm-71	200	4	p38	p38	NOUN
bptjm-71	200	5	mapk	mapk	NOUN
bptjm-71	200	6	has	have	AUX
bptjm-71	200	7	been	be	AUX
bptjm-71	200	8	observed	observe	VERB
bptjm-71	200	9	in	in	ADP
bptjm-71	200	10	senescent	senescent	ADJ
bptjm-71	200	11	cells	cell	NOUN
bptjm-71	200	12	indicating	indicate	VERB
bptjm-71	200	13	an	an	DET
bptjm-71	200	14	involvement	involvement	NOUN
bptjm-71	200	15	in	in	ADP
bptjm-71	200	16	the	the	DET
bptjm-71	200	17	cellular	cellular	ADJ
bptjm-71	200	18	senescence	senescence	NOUN
bptjm-71	200	19	process	process	NOUN
bptjm-71	200	20	.	.	PUNCT
bptjm-71	201	1	in	in	ADP
bptjm-71	201	2	an	an	DET
bptjm-71	201	3	α	α	NOUN
bptjm-71	201	4	-	-	PUNCT
bptjm-71	201	5	synuclein	synuclein	NOUN
bptjm-71	201	6	mouse	mouse	NOUN
bptjm-71	201	7	model	model	NOUN
bptjm-71	201	8	of	of	ADP
bptjm-71	201	9	parkinson	parkinson	NOUN
bptjm-71	201	10	’s	’s	PART
bptjm-71	201	11	disease	disease	NOUN
bptjm-71	201	12	it	it	PRON
bptjm-71	201	13	has	have	AUX
bptjm-71	201	14	been	be	AUX
bptjm-71	201	15	shown	show	VERB
bptjm-71	201	16	to	to	PART
bptjm-71	201	17	promote	promote	VERB
bptjm-71	201	18	mitochondrial	mitochondrial	ADJ
bptjm-71	201	19	fission	fission	NOUN
bptjm-71	201	20	.	.	PUNCT
bptjm-71	202	1	chemical	chemical	NOUN
bptjm-71	202	2	inhibition	inhibition	NOUN
bptjm-71	202	3	of	of	ADP
bptjm-71	202	4	p38	p38	NOUN
bptjm-71	202	5	map	map	NOUN
bptjm-71	202	6	with	with	ADP
bptjm-71	202	7	molecule	molecule	NOUN
bptjm-71	202	8	sb203580	sb203580	NOUN
bptjm-71	202	9	was	be	AUX
bptjm-71	202	10	shown	show	VERB
bptjm-71	202	11	to	to	PART
bptjm-71	202	12	protect	protect	VERB
bptjm-71	202	13	cells	cell	NOUN
bptjm-71	202	14	from	from	ADP
bptjm-71	202	15	mitochondrial	mitochondrial	ADJ
bptjm-71	202	16	dysfunction	dysfunction	NOUN
bptjm-71	202	17	and	and	CCONJ
bptjm-71	202	18	cell	cell	NOUN
bptjm-71	202	19	death.74	death.74	ADJ
bptjm-71	202	20	additionally	additionally	ADV
bptjm-71	202	21	,	,	PUNCT
bptjm-71	202	22	p38mapk	p38mapk	PROPN
bptjm-71	202	23	plays	play	VERB
bptjm-71	202	24	berkeley	berkeley	PROPN
bptjm-71	202	25	pharma	pharma	PROPN
bptjm-71	202	26	tech	tech	NOUN
bptjm-71	202	27	journal	journal	NOUN
bptjm-71	202	28	of	of	ADP
bptjm-71	202	29	medicine	medicine	NOUN
bptjm-71	202	30	|	|	ADV
bptjm-71	202	31	65	65	NUM
bptjm-71	202	32	a	a	DET
bptjm-71	202	33	crucial	crucial	ADJ
bptjm-71	202	34	role	role	NOUN
bptjm-71	202	35	in	in	ADP
bptjm-71	202	36	the	the	DET
bptjm-71	202	37	secretion	secretion	NOUN
bptjm-71	202	38	of	of	ADP
bptjm-71	202	39	sasp	sasp	NOUN
bptjm-71	202	40	factors	factor	NOUN
bptjm-71	202	41	.	.	PUNCT
bptjm-71	203	1	interestingly	interestingly	ADV
bptjm-71	203	2	,	,	PUNCT
bptjm-71	203	3	p38mapk	p38mapk	PROPN
bptjm-71	203	4	can	can	AUX
bptjm-71	203	5	induce	induce	VERB
bptjm-71	203	6	sasp	sasp	NOUN
bptjm-71	203	7	independently	independently	ADV
bptjm-71	203	8	of	of	ADP
bptjm-71	203	9	the	the	DET
bptjm-71	203	10	dna	dna	PROPN
bptjm-71	203	11	damage	damage	NOUN
bptjm-71	203	12	response	response	NOUN
bptjm-71	203	13	(	(	PUNCT
bptjm-71	203	14	ddr	ddr	PROPN
bptjm-71	203	15	)	)	PUNCT
bptjm-71	203	16	,	,	PUNCT
bptjm-71	203	17	suggesting	suggest	VERB
bptjm-71	203	18	its	its	PRON
bptjm-71	203	19	significance	significance	NOUN
bptjm-71	203	20	as	as	ADP
bptjm-71	203	21	a	a	DET
bptjm-71	203	22	separate	separate	ADJ
bptjm-71	203	23	pathway	pathway	NOUN
bptjm-71	203	24	for	for	ADP
bptjm-71	203	25	sasp	sasp	NOUN
bptjm-71	203	26	activation	activation	NOUN
bptjm-71	203	27	.	.	PUNCT
bptjm-71	204	1	thus	thus	ADV
bptjm-71	204	2	,	,	PUNCT
bptjm-71	204	3	when	when	SCONJ
bptjm-71	204	4	p38	p38	NOUN
bptjm-71	204	5	mapk	mapk	NOUN
bptjm-71	204	6	is	be	AUX
bptjm-71	204	7	inhibited	inhibit	VERB
bptjm-71	204	8	,	,	PUNCT
bptjm-71	204	9	it	it	PRON
bptjm-71	204	10	has	have	AUX
bptjm-71	204	11	been	be	AUX
bptjm-71	204	12	found	find	VERB
bptjm-71	204	13	to	to	PART
bptjm-71	204	14	effectively	effectively	ADV
bptjm-71	204	15	suppress	suppress	VERB
bptjm-71	204	16	the	the	DET
bptjm-71	204	17	sasp	sasp	NOUN
bptjm-71	204	18	,	,	PUNCT
bptjm-71	204	19	potentially	potentially	ADV
bptjm-71	204	20	offering	offer	VERB
bptjm-71	204	21	a	a	DET
bptjm-71	204	22	promising	promising	ADJ
bptjm-71	204	23	target	target	NOUN
bptjm-71	204	24	for	for	ADP
bptjm-71	204	25	therapeutic	therapeutic	ADJ
bptjm-71	204	26	interventions	intervention	NOUN
bptjm-71	204	27	aimed	aim	VERB
bptjm-71	204	28	at	at	ADP
bptjm-71	204	29	mitigating	mitigate	VERB
bptjm-71	204	30	the	the	DET
bptjm-71	204	31	harmful	harmful	ADJ
bptjm-71	204	32	effects	effect	NOUN
bptjm-71	204	33	associated	associate	VERB
bptjm-71	204	34	with	with	ADP
bptjm-71	204	35	cellular	cellular	ADJ
bptjm-71	204	36	senescence.75	senescence.75	PROPN
bptjm-71	204	37	furthermore	furthermore	ADV
bptjm-71	204	38	,	,	PUNCT
bptjm-71	204	39	it	it	PRON
bptjm-71	204	40	is	be	AUX
bptjm-71	204	41	interesting	interesting	ADJ
bptjm-71	204	42	to	to	PART
bptjm-71	204	43	note	note	VERB
bptjm-71	204	44	that	that	SCONJ
bptjm-71	204	45	mapks	mapks	NOUN
bptjm-71	204	46	and	and	CCONJ
bptjm-71	204	47	nf	nf	NOUN
bptjm-71	204	48	-	-	PUNCT
bptjm-71	204	49	κb	κb	NOUN
bptjm-71	204	50	have	have	AUX
bptjm-71	204	51	been	be	AUX
bptjm-71	204	52	found	find	VERB
bptjm-71	204	53	to	to	PART
bptjm-71	204	54	regulate	regulate	VERB
bptjm-71	204	55	the	the	DET
bptjm-71	204	56	expression	expression	NOUN
bptjm-71	204	57	of	of	ADP
bptjm-71	204	58	the	the	DET
bptjm-71	204	59	other	other	ADJ
bptjm-71	204	60	in	in	ADP
bptjm-71	204	61	a	a	DET
bptjm-71	204	62	feedback	feedback	NOUN
bptjm-71	204	63	mechanism	mechanism	NOUN
bptjm-71	204	64	,	,	PUNCT
bptjm-71	204	65	suggesting	suggest	VERB
bptjm-71	204	66	inhibition	inhibition	NOUN
bptjm-71	204	67	could	could	AUX
bptjm-71	204	68	lead	lead	VERB
bptjm-71	204	69	to	to	ADP
bptjm-71	204	70	regulation	regulation	NOUN
bptjm-71	204	71	of	of	ADP
bptjm-71	204	72	sasps.76,77	sasps.76,77	NOUN
bptjm-71	204	73	further	further	ADJ
bptjm-71	204	74	research	research	NOUN
bptjm-71	204	75	on	on	ADP
bptjm-71	204	76	p38	p38	NOUN
bptjm-71	204	77	mapk	mapk	NOUN
bptjm-71	204	78	's	's	PART
bptjm-71	204	79	intricate	intricate	ADJ
bptjm-71	204	80	role	role	NOUN
bptjm-71	204	81	in	in	ADP
bptjm-71	204	82	senescence	senescence	NOUN
bptjm-71	204	83	and	and	CCONJ
bptjm-71	204	84	its	its	PRON
bptjm-71	204	85	modulation	modulation	NOUN
bptjm-71	204	86	may	may	AUX
bptjm-71	204	87	provide	provide	VERB
bptjm-71	204	88	valuable	valuable	ADJ
bptjm-71	204	89	insights	insight	NOUN
bptjm-71	204	90	into	into	ADP
bptjm-71	204	91	aging	age	VERB
bptjm-71	204	92	-	-	PUNCT
bptjm-71	204	93	related	relate	VERB
bptjm-71	204	94	processes	process	NOUN
bptjm-71	204	95	and	and	CCONJ
bptjm-71	204	96	age	age	NOUN
bptjm-71	204	97	-	-	PUNCT
bptjm-71	204	98	associated	associate	VERB
bptjm-71	204	99	diseases	disease	NOUN
bptjm-71	204	100	.	.	PUNCT
bptjm-71	205	1	while	while	SCONJ
bptjm-71	205	2	specific	specific	ADJ
bptjm-71	205	3	therapies	therapy	NOUN
bptjm-71	205	4	that	that	PRON
bptjm-71	205	5	target	target	NOUN
bptjm-71	205	6	mapks	mapks	NOUN
bptjm-71	205	7	have	have	AUX
bptjm-71	205	8	not	not	PART
bptjm-71	205	9	yet	yet	ADV
bptjm-71	205	10	been	be	AUX
bptjm-71	205	11	thoroughly	thoroughly	ADV
bptjm-71	205	12	developed	develop	VERB
bptjm-71	205	13	,	,	PUNCT
bptjm-71	205	14	these	these	DET
bptjm-71	205	15	findings	finding	NOUN
bptjm-71	205	16	point	point	VERB
bptjm-71	205	17	to	to	ADP
bptjm-71	205	18	the	the	DET
bptjm-71	205	19	great	great	ADJ
bptjm-71	205	20	potential	potential	NOUN
bptjm-71	205	21	of	of	ADP
bptjm-71	205	22	mapk	mapk	NOUN
bptjm-71	205	23	-	-	PUNCT
bptjm-71	205	24	based	base	VERB
bptjm-71	205	25	treatments	treatment	NOUN
bptjm-71	205	26	.	.	PUNCT
bptjm-71	206	1	limitations	limitation	NOUN
bptjm-71	206	2	excessive	excessive	ADJ
bptjm-71	206	3	and	and	CCONJ
bptjm-71	206	4	constitutive	constitutive	ADJ
bptjm-71	206	5	mitophagy	mitophagy	NOUN
bptjm-71	206	6	may	may	AUX
bptjm-71	206	7	contribute	contribute	VERB
bptjm-71	206	8	notably	notably	ADV
bptjm-71	206	9	to	to	ADP
bptjm-71	206	10	the	the	DET
bptjm-71	206	11	progression	progression	NOUN
bptjm-71	206	12	of	of	ADP
bptjm-71	206	13	neurodegenerative	neurodegenerative	ADJ
bptjm-71	206	14	disease	disease	NOUN
bptjm-71	206	15	.	.	PUNCT
bptjm-71	207	1	in	in	ADP
bptjm-71	207	2	addition	addition	NOUN
bptjm-71	207	3	,	,	PUNCT
bptjm-71	207	4	in	in	ADP
bptjm-71	207	5	vitro	vitro	X
bptjm-71	207	6	studies	study	NOUN
bptjm-71	207	7	on	on	ADP
bptjm-71	207	8	chronic	chronic	ADJ
bptjm-71	207	9	obstructive	obstructive	ADJ
bptjm-71	207	10	pulmonary	pulmonary	ADJ
bptjm-71	207	11	disease	disease	NOUN
bptjm-71	207	12	(	(	PUNCT
bptjm-71	207	13	cpod	cpod	NOUN
bptjm-71	207	14	)	)	PUNCT
bptjm-71	207	15	epithelial	epithelial	ADJ
bptjm-71	207	16	cells	cell	NOUN
bptjm-71	207	17	found	find	VERB
bptjm-71	207	18	that	that	SCONJ
bptjm-71	207	19	cigarette	cigarette	NOUN
bptjm-71	207	20	smoke	smoke	NOUN
bptjm-71	207	21	activated	activate	VERB
bptjm-71	207	22	mapk15	mapk15	NOUN
bptjm-71	207	23	signaling	signal	VERB
bptjm-71	207	24	and	and	CCONJ
bptjm-71	207	25	led	lead	VERB
bptjm-71	207	26	to	to	PART
bptjm-71	207	27	oxidative	oxidative	ADJ
bptjm-71	207	28	stress	stress	NOUN
bptjm-71	207	29	,	,	PUNCT
bptjm-71	207	30	rather	rather	ADV
bptjm-71	207	31	than	than	ADP
bptjm-71	207	32	the	the	DET
bptjm-71	207	33	opposite	opposite	NOUN
bptjm-71	207	34	,	,	PUNCT
bptjm-71	207	35	as	as	SCONJ
bptjm-71	207	36	what	what	PRON
bptjm-71	207	37	has	have	AUX
bptjm-71	207	38	been	be	AUX
bptjm-71	207	39	more	more	ADV
bptjm-71	207	40	commonly	commonly	ADV
bptjm-71	207	41	discovered	discover	VERB
bptjm-71	207	42	in	in	ADP
bptjm-71	207	43	other	other	ADJ
bptjm-71	207	44	studies.78	studies.78	NOUN
bptjm-71	207	45	hence	hence	ADV
bptjm-71	207	46	,	,	PUNCT
bptjm-71	207	47	patients	patient	NOUN
bptjm-71	207	48	with	with	ADP
bptjm-71	207	49	neurodegenerative	neurodegenerative	ADJ
bptjm-71	207	50	diseases	disease	NOUN
bptjm-71	207	51	that	that	PRON
bptjm-71	207	52	smoke	smoke	NOUN
bptjm-71	207	53	may	may	AUX
bptjm-71	207	54	encounter	encounter	VERB
bptjm-71	207	55	additional	additional	ADJ
bptjm-71	207	56	barriers	barrier	NOUN
bptjm-71	207	57	to	to	ADP
bptjm-71	207	58	treatment	treatment	NOUN
bptjm-71	207	59	with	with	ADP
bptjm-71	207	60	mapk15	mapk15	ADV
bptjm-71	207	61	-	-	PUNCT
bptjm-71	207	62	targeted	target	VERB
bptjm-71	207	63	therapies.the	therapies.the	DET
bptjm-71	207	64	p38	p38	NOUN
bptjm-71	207	65	mapk	mapk	NOUN
bptjm-71	207	66	has	have	AUX
bptjm-71	207	67	also	also	ADV
bptjm-71	207	68	been	be	AUX
bptjm-71	207	69	linked	link	VERB
bptjm-71	207	70	to	to	ADP
bptjm-71	207	71	oxidative	oxidative	ADJ
bptjm-71	207	72	stress	stress	NOUN
bptjm-71	207	73	,	,	PUNCT
bptjm-71	207	74	playing	play	VERB
bptjm-71	207	75	a	a	DET
bptjm-71	207	76	role	role	NOUN
bptjm-71	207	77	in	in	ADP
bptjm-71	207	78	the	the	DET
bptjm-71	207	79	induction	induction	NOUN
bptjm-71	207	80	of	of	ADP
bptjm-71	207	81	senescence	senescence	NOUN
bptjm-71	207	82	.	.	PUNCT
bptjm-71	208	1	thus	thus	ADV
bptjm-71	208	2	caution	caution	NOUN
bptjm-71	208	3	of	of	ADP
bptjm-71	208	4	these	these	DET
bptjm-71	208	5	therapies	therapy	NOUN
bptjm-71	208	6	is	be	AUX
bptjm-71	208	7	essential	essential	ADJ
bptjm-71	208	8	in	in	ADP
bptjm-71	208	9	order	order	NOUN
bptjm-71	208	10	to	to	PART
bptjm-71	208	11	avoid	avoid	VERB
bptjm-71	208	12	producing	produce	VERB
bptjm-71	208	13	the	the	DET
bptjm-71	208	14	opposite	opposite	ADJ
bptjm-71	208	15	effect	effect	NOUN
bptjm-71	208	16	.	.	PUNCT
bptjm-71	209	1	4	4	X
bptjm-71	209	2	.	.	X
bptjm-71	209	3	future	future	ADJ
bptjm-71	209	4	directions	direction	NOUN
bptjm-71	209	5	it	it	PRON
bptjm-71	209	6	is	be	AUX
bptjm-71	209	7	crucial	crucial	ADJ
bptjm-71	209	8	to	to	PART
bptjm-71	209	9	explore	explore	VERB
bptjm-71	209	10	the	the	DET
bptjm-71	209	11	heterogeneity	heterogeneity	NOUN
bptjm-71	209	12	of	of	ADP
bptjm-71	209	13	senescent	senescent	ADJ
bptjm-71	209	14	cells	cell	NOUN
bptjm-71	209	15	and	and	CCONJ
bptjm-71	209	16	their	their	PRON
bptjm-71	209	17	distinct	distinct	ADJ
bptjm-71	209	18	contributions	contribution	NOUN
bptjm-71	209	19	to	to	ADP
bptjm-71	209	20	neurodegeneration	neurodegeneration	NOUN
bptjm-71	209	21	.	.	PUNCT
bptjm-71	210	1	understanding	understand	VERB
bptjm-71	210	2	the	the	DET
bptjm-71	210	3	specific	specific	ADJ
bptjm-71	210	4	factors	factor	NOUN
bptjm-71	210	5	and	and	CCONJ
bptjm-71	210	6	signaling	signal	VERB
bptjm-71	210	7	pathways	pathway	NOUN
bptjm-71	210	8	that	that	PRON
bptjm-71	210	9	drive	drive	VERB
bptjm-71	210	10	the	the	DET
bptjm-71	210	11	detrimental	detrimental	ADJ
bptjm-71	210	12	effects	effect	NOUN
bptjm-71	210	13	of	of	ADP
bptjm-71	210	14	different	different	ADJ
bptjm-71	210	15	senescent	senescent	ADJ
bptjm-71	210	16	cells	cell	NOUN
bptjm-71	210	17	in	in	ADP
bptjm-71	210	18	neurodegenerative	neurodegenerative	ADJ
bptjm-71	210	19	diseases	disease	NOUN
bptjm-71	210	20	will	will	AUX
bptjm-71	210	21	help	help	VERB
bptjm-71	210	22	guide	guide	VERB
bptjm-71	210	23	the	the	DET
bptjm-71	210	24	development	development	NOUN
bptjm-71	210	25	of	of	ADP
bptjm-71	210	26	targeted	target	VERB
bptjm-71	210	27	therapies	therapy	NOUN
bptjm-71	210	28	.	.	PUNCT
bptjm-71	211	1	one	one	NUM
bptjm-71	211	2	area	area	NOUN
bptjm-71	211	3	that	that	PRON
bptjm-71	211	4	could	could	AUX
bptjm-71	211	5	be	be	AUX
bptjm-71	211	6	further	far	ADV
bptjm-71	211	7	explored	explore	VERB
bptjm-71	211	8	is	be	AUX
bptjm-71	211	9	the	the	DET
bptjm-71	211	10	use	use	NOUN
bptjm-71	211	11	of	of	ADP
bptjm-71	211	12	targeted	target	VERB
bptjm-71	211	13	therapies	therapy	NOUN
bptjm-71	211	14	.	.	PUNCT
bptjm-71	212	1	some	some	DET
bptjm-71	212	2	research	research	NOUN
bptjm-71	212	3	has	have	AUX
bptjm-71	212	4	been	be	AUX
bptjm-71	212	5	done	do	VERB
bptjm-71	212	6	but	but	CCONJ
bptjm-71	212	7	needs	need	VERB
bptjm-71	212	8	to	to	PART
bptjm-71	212	9	be	be	AUX
bptjm-71	212	10	expanded	expand	VERB
bptjm-71	212	11	upon	upon	SCONJ
bptjm-71	212	12	for	for	ADP
bptjm-71	212	13	applications	application	NOUN
bptjm-71	212	14	in	in	ADP
bptjm-71	212	15	neurodegenerative	neurodegenerative	ADJ
bptjm-71	212	16	diseases	disease	NOUN
bptjm-71	212	17	.	.	PUNCT
bptjm-71	213	1	one	one	NUM
bptjm-71	213	2	of	of	ADP
bptjm-71	213	3	those	those	PRON
bptjm-71	213	4	is	be	AUX
bptjm-71	213	5	berkeley	berkeley	PROPN
bptjm-71	213	6	pharma	pharma	PROPN
bptjm-71	213	7	tech	tech	NOUN
bptjm-71	213	8	journal	journal	NOUN
bptjm-71	213	9	of	of	ADP
bptjm-71	213	10	medicine	medicine	NOUN
bptjm-71	213	11	|	|	ADV
bptjm-71	213	12	66	66	NUM
bptjm-71	213	13	second	second	ADJ
bptjm-71	213	14	-	-	PUNCT
bptjm-71	213	15	generation	generation	NOUN
bptjm-71	213	16	senolytics	senolytic	NOUN
bptjm-71	213	17	:	:	PUNCT
bptjm-71	213	18	they	they	PRON
bptjm-71	213	19	offer	offer	VERB
bptjm-71	213	20	a	a	DET
bptjm-71	213	21	specific	specific	ADJ
bptjm-71	213	22	approach	approach	NOUN
bptjm-71	213	23	to	to	PART
bptjm-71	213	24	enhance	enhance	VERB
bptjm-71	213	25	the	the	DET
bptjm-71	213	26	effectiveness	effectiveness	NOUN
bptjm-71	213	27	of	of	ADP
bptjm-71	213	28	existing	exist	VERB
bptjm-71	213	29	senolytic	senolytic	ADJ
bptjm-71	213	30	drugs	drug	NOUN
bptjm-71	213	31	while	while	SCONJ
bptjm-71	213	32	minimizing	minimize	VERB
bptjm-71	213	33	the	the	DET
bptjm-71	213	34	side	side	NOUN
bptjm-71	213	35	effects	effect	NOUN
bptjm-71	213	36	.	.	PUNCT
bptjm-71	214	1	an	an	DET
bptjm-71	214	2	example	example	NOUN
bptjm-71	214	3	is	be	AUX
bptjm-71	214	4	b2	b2	PROPN
bptjm-71	214	5	m	m	PROPN
bptjm-71	214	6	adc	adc	PROPN
bptjm-71	214	7	,	,	PUNCT
bptjm-71	214	8	an	an	DET
bptjm-71	214	9	antibody	antibody	NOUN
bptjm-71	214	10	conjugation	conjugation	NOUN
bptjm-71	214	11	that	that	PRON
bptjm-71	214	12	increases	increase	VERB
bptjm-71	214	13	efficacy	efficacy	NOUN
bptjm-71	214	14	and	and	CCONJ
bptjm-71	214	15	selectivity	selectivity	NOUN
bptjm-71	214	16	when	when	SCONJ
bptjm-71	214	17	it	it	PRON
bptjm-71	214	18	comes	come	VERB
bptjm-71	214	19	to	to	ADP
bptjm-71	214	20	using	use	VERB
bptjm-71	214	21	senolytics	senolytic	NOUN
bptjm-71	214	22	to	to	ADP
bptjm-71	214	23	clear	clear	ADJ
bptjm-71	214	24	senescent	senescent	ADJ
bptjm-71	214	25	cells.79	cells.79	NOUN
bptjm-71	214	26	future	future	ADJ
bptjm-71	214	27	research	research	NOUN
bptjm-71	214	28	in	in	ADP
bptjm-71	214	29	combining	combine	VERB
bptjm-71	214	30	strategies	strategy	NOUN
bptjm-71	214	31	,	,	PUNCT
bptjm-71	214	32	like	like	ADP
bptjm-71	214	33	using	use	VERB
bptjm-71	214	34	senolytic	senolytic	ADJ
bptjm-71	214	35	drugs	drug	NOUN
bptjm-71	214	36	and	and	CCONJ
bptjm-71	214	37	immunotherapy	immunotherapy	NOUN
bptjm-71	214	38	simultaneously	simultaneously	ADV
bptjm-71	214	39	promises	promise	VERB
bptjm-71	214	40	potential	potential	ADJ
bptjm-71	214	41	benefits	benefit	NOUN
bptjm-71	214	42	as	as	ADV
bptjm-71	214	43	well	well	ADV
bptjm-71	214	44	.	.	PUNCT
bptjm-71	215	1	similar	similar	ADJ
bptjm-71	215	2	to	to	ADP
bptjm-71	215	3	how	how	SCONJ
bptjm-71	215	4	car	car	NOUN
bptjm-71	215	5	t	t	NOUN
bptjm-71	215	6	cell	cell	NOUN
bptjm-71	215	7	therapy	therapy	NOUN
bptjm-71	215	8	has	have	AUX
bptjm-71	215	9	been	be	AUX
bptjm-71	215	10	used	use	VERB
bptjm-71	215	11	to	to	PART
bptjm-71	215	12	treat	treat	VERB
bptjm-71	215	13	cancers	cancer	NOUN
bptjm-71	215	14	,	,	PUNCT
bptjm-71	215	15	this	this	DET
bptjm-71	215	16	therapy	therapy	NOUN
bptjm-71	215	17	can	can	AUX
bptjm-71	215	18	be	be	AUX
bptjm-71	215	19	applied	apply	VERB
bptjm-71	215	20	and	and	CCONJ
bptjm-71	215	21	engineered	engineer	VERB
bptjm-71	215	22	to	to	PART
bptjm-71	215	23	target	target	VERB
bptjm-71	215	24	senescent	senescent	ADJ
bptjm-71	215	25	biomarkers	biomarker	NOUN
bptjm-71	215	26	for	for	ADP
bptjm-71	215	27	neurodegenerative	neurodegenerative	ADJ
bptjm-71	215	28	diseases	disease	NOUN
bptjm-71	215	29	.	.	PUNCT
bptjm-71	216	1	so	so	ADV
bptjm-71	216	2	far	far	ADV
bptjm-71	216	3	very	very	ADV
bptjm-71	216	4	limited	limited	ADJ
bptjm-71	216	5	research	research	NOUN
bptjm-71	216	6	has	have	AUX
bptjm-71	216	7	been	be	AUX
bptjm-71	216	8	done	do	VERB
bptjm-71	216	9	in	in	ADP
bptjm-71	216	10	this	this	DET
bptjm-71	216	11	area	area	NOUN
bptjm-71	216	12	but	but	CCONJ
bptjm-71	216	13	amor	amor	PROPN
bptjm-71	216	14	et	et	PROPN
bptjm-71	216	15	al	al	PROPN
bptjm-71	216	16	.	.	PROPN
bptjm-71	216	17	successfully	successfully	ADV
bptjm-71	216	18	created	create	VERB
bptjm-71	216	19	a	a	DET
bptjm-71	216	20	senolytic	senolytic	ADJ
bptjm-71	216	21	car	car	NOUN
bptjm-71	216	22	t	t	NOUN
bptjm-71	216	23	therapy	therapy	NOUN
bptjm-71	216	24	that	that	PRON
bptjm-71	216	25	effectively	effectively	ADV
bptjm-71	216	26	eliminated	eliminate	VERB
bptjm-71	216	27	senescent	senescent	ADJ
bptjm-71	216	28	cells	cell	NOUN
bptjm-71	216	29	in	in	ADP
bptjm-71	216	30	mouse	mouse	NOUN
bptjm-71	216	31	models	model	NOUN
bptjm-71	216	32	and	and	CCONJ
bptjm-71	216	33	improved	improve	VERB
bptjm-71	216	34	outcomes	outcome	NOUN
bptjm-71	216	35	in	in	ADP
bptjm-71	216	36	liver	liver	NOUN
bptjm-71	216	37	fibrosis	fibrosis	NOUN
bptjm-71	216	38	.	.	PUNCT
bptjm-71	217	1	however	however	ADV
bptjm-71	217	2	,	,	PUNCT
bptjm-71	217	3	this	this	DET
bptjm-71	217	4	technique	technique	NOUN
bptjm-71	217	5	comes	come	VERB
bptjm-71	217	6	with	with	ADP
bptjm-71	217	7	its	its	PRON
bptjm-71	217	8	limitations	limitation	NOUN
bptjm-71	217	9	.	.	PUNCT
bptjm-71	218	1	a	a	DET
bptjm-71	218	2	condition	condition	NOUN
bptjm-71	218	3	called	call	VERB
bptjm-71	218	4	cytokine	cytokine	ADJ
bptjm-71	218	5	release	release	NOUN
bptjm-71	218	6	syndrome	syndrome	NOUN
bptjm-71	218	7	may	may	AUX
bptjm-71	218	8	arise	arise	VERB
bptjm-71	218	9	,	,	PUNCT
bptjm-71	218	10	in	in	ADP
bptjm-71	218	11	which	which	PRON
bptjm-71	218	12	an	an	DET
bptjm-71	218	13	intense	intense	ADJ
bptjm-71	218	14	storm	storm	NOUN
bptjm-71	218	15	of	of	ADP
bptjm-71	218	16	t	t	PROPN
bptjm-71	218	17	cells	cell	NOUN
bptjm-71	218	18	causes	cause	VERB
bptjm-71	218	19	fever	fever	NOUN
bptjm-71	218	20	and	and	CCONJ
bptjm-71	218	21	impacts	impact	NOUN
bptjm-71	218	22	breathing	breathing	NOUN
bptjm-71	218	23	and	and	CCONJ
bptjm-71	218	24	blood	blood	NOUN
bptjm-71	218	25	pressure.80	pressure.80	NOUN
bptjm-71	218	26	in	in	ADP
bptjm-71	218	27	addition	addition	NOUN
bptjm-71	218	28	,	,	PUNCT
bptjm-71	218	29	antibodies	antibody	NOUN
bptjm-71	218	30	made	make	VERB
bptjm-71	218	31	to	to	PART
bptjm-71	218	32	neutralize	neutralize	VERB
bptjm-71	218	33	sasps	sasp	NOUN
bptjm-71	218	34	are	be	AUX
bptjm-71	218	35	another	another	DET
bptjm-71	218	36	promising	promising	ADJ
bptjm-71	218	37	avenue	avenue	NOUN
bptjm-71	218	38	to	to	PART
bptjm-71	218	39	take	take	VERB
bptjm-71	218	40	in	in	ADP
bptjm-71	218	41	the	the	DET
bptjm-71	218	42	path	path	NOUN
bptjm-71	218	43	of	of	ADP
bptjm-71	218	44	immunotherapy	immunotherapy	NOUN
bptjm-71	218	45	treatments	treatment	NOUN
bptjm-71	218	46	.	.	PUNCT
bptjm-71	219	1	particularly	particularly	ADV
bptjm-71	219	2	,	,	PUNCT
bptjm-71	219	3	intervention	intervention	NOUN
bptjm-71	219	4	of	of	ADP
bptjm-71	219	5	cytokine	cytokine	NOUN
bptjm-71	219	6	il27	il27	PROPN
bptjm-71	219	7	as	as	ADV
bptjm-71	219	8	well	well	ADV
bptjm-71	219	9	as	as	ADP
bptjm-71	219	10	the	the	DET
bptjm-71	219	11	upregulation	upregulation	NOUN
bptjm-71	219	12	of	of	ADP
bptjm-71	219	13	mhc	mhc	PROPN
bptjm-71	219	14	class	class	PROPN
bptjm-71	219	15	-	-	PUNCT
bptjm-71	219	16	i	i	NOUN
bptjm-71	219	17	-	-	PUNCT
bptjm-71	219	18	related	relate	VERB
bptjm-71	219	19	molecules	molecule	NOUN
bptjm-71	219	20	,	,	PUNCT
bptjm-71	219	21	such	such	ADJ
bptjm-71	219	22	as	as	ADP
bptjm-71	219	23	rae1	rae1	NOUN
bptjm-71	219	24	can	can	AUX
bptjm-71	219	25	be	be	AUX
bptjm-71	219	26	applied	apply	VERB
bptjm-71	219	27	to	to	PART
bptjm-71	219	28	alleviate	alleviate	VERB
bptjm-71	219	29	senescence	senescence	NOUN
bptjm-71	219	30	burden	burden	NOUN
bptjm-71	219	31	and	and	CCONJ
bptjm-71	219	32	interaction	interaction	NOUN
bptjm-71	219	33	between	between	ADP
bptjm-71	219	34	nk	nk	PROPN
bptjm-71	219	35	cells	cell	NOUN
bptjm-71	219	36	and	and	CCONJ
bptjm-71	219	37	receptor	receptor	NOUN
bptjm-71	219	38	nkg2d	nkg2d	PROPN
bptjm-71	219	39	,	,	PUNCT
bptjm-71	219	40	which	which	PRON
bptjm-71	219	41	influences	influence	VERB
bptjm-71	219	42	age	age	NOUN
bptjm-71	219	43	-	-	PUNCT
bptjm-71	219	44	related	relate	VERB
bptjm-71	219	45	decline	decline	NOUN
bptjm-71	219	46	in	in	ADP
bptjm-71	219	47	neurogenesis	neurogenesis	NOUN
bptjm-71	219	48	and	and	CCONJ
bptjm-71	219	49	cognition.19	cognition.19	VERB
bptjm-71	219	50	another	another	DET
bptjm-71	219	51	area	area	NOUN
bptjm-71	219	52	of	of	ADP
bptjm-71	219	53	research	research	NOUN
bptjm-71	219	54	is	be	AUX
bptjm-71	219	55	in	in	ADP
bptjm-71	219	56	leveraging	leverage	VERB
bptjm-71	219	57	the	the	DET
bptjm-71	219	58	lymphatic	lymphatic	ADJ
bptjm-71	219	59	system	system	NOUN
bptjm-71	219	60	,	,	PUNCT
bptjm-71	219	61	which	which	PRON
bptjm-71	219	62	plays	play	VERB
bptjm-71	219	63	an	an	DET
bptjm-71	219	64	imperative	imperative	ADJ
bptjm-71	219	65	role	role	NOUN
bptjm-71	219	66	in	in	ADP
bptjm-71	219	67	clearing	clear	VERB
bptjm-71	219	68	senescent	senescent	ADJ
bptjm-71	219	69	cells	cell	NOUN
bptjm-71	219	70	and	and	CCONJ
bptjm-71	219	71	therefore	therefore	ADV
bptjm-71	219	72	preventing	prevent	VERB
bptjm-71	219	73	neurodegenerative	neurodegenerative	ADJ
bptjm-71	219	74	diseases	disease	NOUN
bptjm-71	219	75	.	.	PUNCT
bptjm-71	220	1	such	such	ADJ
bptjm-71	220	2	diseases	disease	NOUN
bptjm-71	220	3	are	be	AUX
bptjm-71	220	4	known	know	VERB
bptjm-71	220	5	to	to	PART
bptjm-71	220	6	cause	cause	VERB
bptjm-71	220	7	chronic	chronic	ADJ
bptjm-71	220	8	inflammatory	inflammatory	ADJ
bptjm-71	220	9	cascades	cascade	NOUN
bptjm-71	220	10	that	that	PRON
bptjm-71	220	11	damage	damage	NOUN
bptjm-71	220	12	hippocampal	hippocampal	X
bptjm-71	220	13	micro	micro	NOUN
bptjm-71	220	14	vessels	vessel	NOUN
bptjm-71	220	15	and	and	CCONJ
bptjm-71	220	16	therefore	therefore	ADV
bptjm-71	220	17	lymphatic	lymphatic	ADJ
bptjm-71	220	18	drainage	drainage	NOUN
bptjm-71	220	19	.	.	PUNCT
bptjm-71	221	1	this	this	PRON
bptjm-71	221	2	in	in	ADP
bptjm-71	221	3	turn	turn	NOUN
bptjm-71	221	4	creates	create	VERB
bptjm-71	221	5	a	a	DET
bptjm-71	221	6	dangerous	dangerous	ADJ
bptjm-71	221	7	cycle	cycle	NOUN
bptjm-71	221	8	where	where	SCONJ
bptjm-71	221	9	the	the	DET
bptjm-71	221	10	disease	disease	NOUN
bptjm-71	221	11	causes	cause	VERB
bptjm-71	221	12	lymphatic	lymphatic	ADJ
bptjm-71	221	13	blockage	blockage	NOUN
bptjm-71	221	14	of	of	ADP
bptjm-71	221	15	senescent	senescent	ADJ
bptjm-71	221	16	cell	cell	NOUN
bptjm-71	221	17	clearance	clearance	NOUN
bptjm-71	221	18	and	and	CCONJ
bptjm-71	221	19	senescent	senescent	ADJ
bptjm-71	221	20	cells	cell	NOUN
bptjm-71	221	21	clearance	clearance	NOUN
bptjm-71	221	22	accelerates	accelerate	VERB
bptjm-71	221	23	cognitive	cognitive	ADJ
bptjm-71	221	24	decline	decline	NOUN
bptjm-71	221	25	that	that	PRON
bptjm-71	221	26	further	further	ADJ
bptjm-71	221	27	damages	damage	NOUN
bptjm-71	221	28	hippocampus	hippocampus	NOUN
bptjm-71	221	29	.	.	PUNCT
bptjm-71	222	1	a	a	DET
bptjm-71	222	2	study	study	NOUN
bptjm-71	222	3	determined	determine	VERB
bptjm-71	222	4	that	that	SCONJ
bptjm-71	222	5	such	such	ADJ
bptjm-71	222	6	drainage	drainage	NOUN
bptjm-71	222	7	is	be	AUX
bptjm-71	222	8	dependent	dependent	ADJ
bptjm-71	222	9	on	on	ADP
bptjm-71	222	10	the	the	DET
bptjm-71	222	11	vegf	vegf	PROPN
bptjm-71	222	12	-	-	PUNCT
bptjm-71	222	13	c	c	PROPN
bptjm-71	222	14	/	/	SYM
bptjm-71	222	15	ccl21	ccl21	NOUN
bptjm-71	222	16	pathway	pathway	NOUN
bptjm-71	222	17	.	.	PUNCT
bptjm-71	223	1	leveraging	leverage	VERB
bptjm-71	223	2	these	these	DET
bptjm-71	223	3	pathways	pathway	NOUN
bptjm-71	223	4	to	to	PART
bptjm-71	223	5	improve	improve	VERB
bptjm-71	223	6	lymphatic	lymphatic	ADJ
bptjm-71	223	7	drainage	drainage	NOUN
bptjm-71	223	8	could	could	AUX
bptjm-71	223	9	prove	prove	VERB
bptjm-71	223	10	extremely	extremely	ADV
bptjm-71	223	11	beneficial	beneficial	ADJ
bptjm-71	223	12	in	in	ADP
bptjm-71	223	13	combination	combination	NOUN
bptjm-71	223	14	with	with	ADP
bptjm-71	223	15	senolytics	senolytic	NOUN
bptjm-71	223	16	like	like	ADP
bptjm-71	223	17	d+q	d+q	PROPN
bptjm-71	223	18	.	.	PUNCT
bptjm-71	224	1	one	one	NUM
bptjm-71	224	2	such	such	ADJ
bptjm-71	224	3	idea	idea	NOUN
bptjm-71	224	4	is	be	AUX
bptjm-71	224	5	dispersing	disperse	VERB
bptjm-71	224	6	astrocyte	astrocyte	NOUN
bptjm-71	224	7	vegf	vegf	PROPN
bptjm-71	224	8	-	-	PUNCT
bptjm-71	224	9	c	c	PROPN
bptjm-71	224	10	into	into	ADP
bptjm-71	224	11	the	the	DET
bptjm-71	224	12	csf	csf	NOUN
bptjm-71	224	13	promoting	promote	VERB
bptjm-71	224	14	lymphangiogenesis	lymphangiogenesis	NOUN
bptjm-71	224	15	,	,	PUNCT
bptjm-71	224	16	and	and	CCONJ
bptjm-71	224	17	thus	thus	ADV
bptjm-71	224	18	enhancing	enhance	VERB
bptjm-71	224	19	drainage	drainage	NOUN
bptjm-71	224	20	of	of	ADP
bptjm-71	224	21	parenchymal	parenchymal	ADJ
bptjm-71	224	22	waste	waste	NOUN
bptjm-71	224	23	to	to	ADP
bptjm-71	224	24	the	the	DET
bptjm-71	224	25	dural	dural	ADJ
bptjm-71	224	26	lymphatics	lymphatic	NOUN
bptjm-71	224	27	.	.	PUNCT
bptjm-71	225	1	given	give	VERB
bptjm-71	225	2	that	that	SCONJ
bptjm-71	225	3	studies	study	NOUN
bptjm-71	225	4	have	have	AUX
bptjm-71	225	5	demonstrated	demonstrate	VERB
bptjm-71	225	6	the	the	DET
bptjm-71	225	7	aggravation	aggravation	NOUN
bptjm-71	225	8	of	of	ADP
bptjm-71	225	9	pathogenic	pathogenic	ADJ
bptjm-71	225	10	tau	tau	PROPN
bptjm-71	225	11	accumulation	accumulation	NOUN
bptjm-71	225	12	in	in	ADP
bptjm-71	225	13	ad	ad	NOUN
bptjm-71	225	14	berkeley	berkeley	PROPN
bptjm-71	225	15	pharma	pharma	PROPN
bptjm-71	225	16	tech	tech	NOUN
bptjm-71	225	17	journal	journal	NOUN
bptjm-71	225	18	of	of	ADP
bptjm-71	225	19	medicine	medicine	NOUN
bptjm-71	225	20	|	|	ADV
bptjm-71	225	21	67	67	NUM
bptjm-71	225	22	mouse	mouse	NOUN
bptjm-71	225	23	models	model	NOUN
bptjm-71	225	24	when	when	SCONJ
bptjm-71	225	25	aqp4	aqp4	PROPN
bptjm-71	225	26	water	water	NOUN
bptjm-71	225	27	channels	channel	NOUN
bptjm-71	225	28	are	be	AUX
bptjm-71	225	29	pharmacologically	pharmacologically	ADV
bptjm-71	225	30	inhibited	inhibit	VERB
bptjm-71	225	31	,	,	PUNCT
bptjm-71	225	32	there	there	PRON
bptjm-71	225	33	is	be	VERB
bptjm-71	225	34	a	a	DET
bptjm-71	225	35	need	need	NOUN
bptjm-71	225	36	for	for	ADP
bptjm-71	225	37	further	further	ADJ
bptjm-71	225	38	research	research	NOUN
bptjm-71	225	39	strategies	strategy	NOUN
bptjm-71	225	40	for	for	ADP
bptjm-71	225	41	mitigating	mitigate	VERB
bptjm-71	225	42	the	the	DET
bptjm-71	225	43	downregulation	downregulation	NOUN
bptjm-71	225	44	of	of	ADP
bptjm-71	225	45	aqp4	aqp4	NOUN
bptjm-71	225	46	water	water	NOUN
bptjm-71	225	47	channels	channel	NOUN
bptjm-71	225	48	in	in	ADP
bptjm-71	225	49	senescent	senescent	ADJ
bptjm-71	225	50	astrocytes	astrocyte	NOUN
bptjm-71	225	51	.	.	PUNCT
bptjm-71	226	1	these	these	DET
bptjm-71	226	2	channels	channel	NOUN
bptjm-71	226	3	play	play	VERB
bptjm-71	226	4	a	a	DET
bptjm-71	226	5	crucial	crucial	ADJ
bptjm-71	226	6	role	role	NOUN
bptjm-71	226	7	in	in	ADP
bptjm-71	226	8	facilitating	facilitate	VERB
bptjm-71	226	9	cerebrospinal	cerebrospinal	ADJ
bptjm-71	226	10	fluid	fluid	NOUN
bptjm-71	226	11	and	and	CCONJ
bptjm-71	226	12	interstitial	interstitial	ADJ
bptjm-71	226	13	fluid	fluid	ADJ
bptjm-71	226	14	exchange	exchange	NOUN
bptjm-71	226	15	,	,	PUNCT
bptjm-71	226	16	thereby	thereby	ADV
bptjm-71	226	17	regulating	regulate	VERB
bptjm-71	226	18	glymphatic	glymphatic	ADJ
bptjm-71	226	19	transport	transport	NOUN
bptjm-71	226	20	and	and	CCONJ
bptjm-71	226	21	helping	help	VERB
bptjm-71	226	22	clear	clear	ADJ
bptjm-71	226	23	senescent	senescent	ADJ
bptjm-71	226	24	cells.23,35	cells.23,35	NOUN
bptjm-71	226	25	overall	overall	ADJ
bptjm-71	226	26	,	,	PUNCT
bptjm-71	226	27	further	further	ADJ
bptjm-71	226	28	research	research	NOUN
bptjm-71	226	29	into	into	ADP
bptjm-71	226	30	second	second	ADJ
bptjm-71	226	31	generation	generation	NOUN
bptjm-71	226	32	-	-	PUNCT
bptjm-71	226	33	senolytics	senolytic	NOUN
bptjm-71	226	34	,	,	PUNCT
bptjm-71	226	35	immunotherapy	immunotherapy	NOUN
bptjm-71	226	36	,	,	PUNCT
bptjm-71	226	37	and	and	CCONJ
bptjm-71	226	38	lymphatic	lymphatic	ADJ
bptjm-71	226	39	drainage	drainage	NOUN
bptjm-71	226	40	can	can	AUX
bptjm-71	226	41	pave	pave	VERB
bptjm-71	226	42	the	the	DET
bptjm-71	226	43	way	way	NOUN
bptjm-71	226	44	for	for	SCONJ
bptjm-71	226	45	improved	improved	ADJ
bptjm-71	226	46	therapies	therapy	NOUN
bptjm-71	226	47	to	to	PART
bptjm-71	226	48	alleviate	alleviate	VERB
bptjm-71	226	49	senescence	senescence	NOUN
bptjm-71	226	50	burden	burden	NOUN
bptjm-71	226	51	and	and	CCONJ
bptjm-71	226	52	neurodegenerative	neurodegenerative	ADJ
bptjm-71	226	53	disease	disease	NOUN
bptjm-71	226	54	onset	onset	NOUN
bptjm-71	226	55	and	and	CCONJ
bptjm-71	226	56	progression	progression	NOUN
bptjm-71	226	57	.	.	PUNCT
bptjm-71	227	1	5	5	X
bptjm-71	227	2	.	.	X
bptjm-71	227	3	conclusion	conclusion	VERB
bptjm-71	227	4	the	the	DET
bptjm-71	227	5	field	field	NOUN
bptjm-71	227	6	of	of	ADP
bptjm-71	227	7	neurodegenerative	neurodegenerative	ADJ
bptjm-71	227	8	diseases	disease	NOUN
bptjm-71	227	9	is	be	AUX
bptjm-71	227	10	only	only	ADV
bptjm-71	227	11	just	just	ADV
bptjm-71	227	12	beginning	begin	VERB
bptjm-71	227	13	to	to	PART
bptjm-71	227	14	be	be	AUX
bptjm-71	227	15	explored	explore	VERB
bptjm-71	227	16	;	;	PUNCT
bptjm-71	227	17	the	the	DET
bptjm-71	227	18	brain	brain	NOUN
bptjm-71	227	19	is	be	AUX
bptjm-71	227	20	a	a	DET
bptjm-71	227	21	complicated	complicated	ADJ
bptjm-71	227	22	area	area	NOUN
bptjm-71	227	23	of	of	ADP
bptjm-71	227	24	study	study	NOUN
bptjm-71	227	25	,	,	PUNCT
bptjm-71	227	26	and	and	CCONJ
bptjm-71	227	27	cognitive	cognitive	ADJ
bptjm-71	227	28	decline	decline	NOUN
bptjm-71	227	29	even	even	ADV
bptjm-71	227	30	moreso	moreso	ADJ
bptjm-71	227	31	.	.	PUNCT
bptjm-71	228	1	in	in	ADP
bptjm-71	228	2	recent	recent	ADJ
bptjm-71	228	3	years	year	NOUN
bptjm-71	228	4	,	,	PUNCT
bptjm-71	228	5	many	many	ADJ
bptjm-71	228	6	potential	potential	ADJ
bptjm-71	228	7	avenues	avenue	NOUN
bptjm-71	228	8	have	have	AUX
bptjm-71	228	9	been	be	AUX
bptjm-71	228	10	explored	explore	VERB
bptjm-71	228	11	for	for	ADP
bptjm-71	228	12	possible	possible	ADJ
bptjm-71	228	13	treatments	treatment	NOUN
bptjm-71	228	14	,	,	PUNCT
bptjm-71	228	15	including	include	VERB
bptjm-71	228	16	senolytics	senolytic	NOUN
bptjm-71	228	17	,	,	PUNCT
bptjm-71	228	18	senomorphics	senomorphic	NOUN
bptjm-71	228	19	,	,	PUNCT
bptjm-71	228	20	and	and	CCONJ
bptjm-71	228	21	mitochondrial	mitochondrial	ADJ
bptjm-71	228	22	-	-	PUNCT
bptjm-71	228	23	targeted	target	VERB
bptjm-71	228	24	therapies	therapy	NOUN
bptjm-71	228	25	.	.	PUNCT
bptjm-71	229	1	senescence	senescence	NOUN
bptjm-71	229	2	is	be	AUX
bptjm-71	229	3	a	a	DET
bptjm-71	229	4	vital	vital	ADJ
bptjm-71	229	5	part	part	NOUN
bptjm-71	229	6	of	of	ADP
bptjm-71	229	7	neurodegenerative	neurodegenerative	ADJ
bptjm-71	229	8	diseases	disease	NOUN
bptjm-71	229	9	,	,	PUNCT
bptjm-71	229	10	and	and	CCONJ
bptjm-71	229	11	understanding	understand	VERB
bptjm-71	229	12	its	its	PRON
bptjm-71	229	13	role	role	NOUN
bptjm-71	229	14	proposes	propose	VERB
bptjm-71	229	15	a	a	DET
bptjm-71	229	16	powerful	powerful	ADJ
bptjm-71	229	17	avenue	avenue	NOUN
bptjm-71	229	18	of	of	ADP
bptjm-71	229	19	treatment	treatment	NOUN
bptjm-71	229	20	.	.	PUNCT
bptjm-71	230	1	constant	constant	ADJ
bptjm-71	230	2	stimuli	stimulus	NOUN
bptjm-71	230	3	,	,	PUNCT
bptjm-71	230	4	such	such	ADJ
bptjm-71	230	5	as	as	ADP
bptjm-71	230	6	nf	nf	NOUN
bptjm-71	230	7	-	-	PUNCT
bptjm-71	230	8	κb	κb	NOUN
bptjm-71	230	9	signaling	signaling	NOUN
bptjm-71	230	10	,	,	PUNCT
bptjm-71	230	11	contributes	contribute	VERB
bptjm-71	230	12	to	to	ADP
bptjm-71	230	13	sasp	sasp	NOUN
bptjm-71	230	14	,	,	PUNCT
bptjm-71	230	15	reinforcing	reinforce	VERB
bptjm-71	230	16	inflammaging	inflammage	VERB
bptjm-71	230	17	by	by	ADP
bptjm-71	230	18	its	its	PRON
bptjm-71	230	19	characteristic	characteristic	ADJ
bptjm-71	230	20	overproduction	overproduction	NOUN
bptjm-71	230	21	of	of	ADP
bptjm-71	230	22	proinflammatory	proinflammatory	ADJ
bptjm-71	230	23	cytokines	cytokine	NOUN
bptjm-71	230	24	and	and	CCONJ
bptjm-71	230	25	chemokines.8	chemokines.8	NOUN
bptjm-71	230	26	in	in	ADP
bptjm-71	230	27	addition	addition	NOUN
bptjm-71	230	28	,	,	PUNCT
bptjm-71	230	29	it	it	PRON
bptjm-71	230	30	is	be	AUX
bptjm-71	230	31	clear	clear	ADJ
bptjm-71	230	32	that	that	SCONJ
bptjm-71	230	33	many	many	ADJ
bptjm-71	230	34	factors	factor	NOUN
bptjm-71	230	35	function	function	VERB
bptjm-71	230	36	to	to	PART
bptjm-71	230	37	induce	induce	VERB
bptjm-71	230	38	and	and	CCONJ
bptjm-71	230	39	maintain	maintain	VERB
bptjm-71	230	40	sasp	sasp	NOUN
bptjm-71	230	41	in	in	ADP
bptjm-71	230	42	a	a	DET
bptjm-71	230	43	positive	positive	ADJ
bptjm-71	230	44	feedback	feedback	NOUN
bptjm-71	230	45	manner	manner	NOUN
bptjm-71	230	46	,	,	PUNCT
bptjm-71	230	47	increasing	increase	VERB
bptjm-71	230	48	senescent	senescent	ADJ
bptjm-71	230	49	cell	cell	NOUN
bptjm-71	230	50	accumulation	accumulation	NOUN
bptjm-71	230	51	and	and	CCONJ
bptjm-71	230	52	exacerbating	exacerbate	VERB
bptjm-71	230	53	chronic	chronic	ADJ
bptjm-71	230	54	inflammation	inflammation	NOUN
bptjm-71	230	55	.	.	PUNCT
bptjm-71	231	1	these	these	DET
bptjm-71	231	2	factors	factor	NOUN
bptjm-71	231	3	contribute	contribute	VERB
bptjm-71	231	4	to	to	ADP
bptjm-71	231	5	a	a	DET
bptjm-71	231	6	neurotoxic	neurotoxic	ADJ
bptjm-71	231	7	environment	environment	NOUN
bptjm-71	231	8	in	in	ADP
bptjm-71	231	9	which	which	PRON
bptjm-71	231	10	neuronal	neuronal	ADJ
bptjm-71	231	11	cell	cell	NOUN
bptjm-71	231	12	death	death	NOUN
bptjm-71	231	13	occurs	occur	VERB
bptjm-71	231	14	,	,	PUNCT
bptjm-71	231	15	advancing	advance	VERB
bptjm-71	231	16	neurodegeneration	neurodegeneration	NOUN
bptjm-71	231	17	in	in	ADP
bptjm-71	231	18	affected	affected	ADJ
bptjm-71	231	19	patients	patient	NOUN
bptjm-71	231	20	.	.	PUNCT
bptjm-71	232	1	extracellular	extracellular	ADJ
bptjm-71	232	2	tau	tau	PROPN
bptjm-71	232	3	can	can	AUX
bptjm-71	232	4	further	far	ADV
bptjm-71	232	5	cause	cause	VERB
bptjm-71	232	6	oxidative	oxidative	ADJ
bptjm-71	232	7	stress	stress	NOUN
bptjm-71	232	8	and	and	CCONJ
bptjm-71	232	9	dna	dna	NOUN
bptjm-71	232	10	damage	damage	NOUN
bptjm-71	232	11	,	,	PUNCT
bptjm-71	232	12	which	which	PRON
bptjm-71	232	13	are	be	AUX
bptjm-71	232	14	known	know	VERB
bptjm-71	232	15	to	to	PART
bptjm-71	232	16	be	be	AUX
bptjm-71	232	17	associated	associate	VERB
bptjm-71	232	18	with	with	ADP
bptjm-71	232	19	induction	induction	NOUN
bptjm-71	232	20	of	of	ADP
bptjm-71	232	21	senescence.4	senescence.4	PROPN
bptjm-71	232	22	in	in	ADP
bptjm-71	232	23	addition	addition	NOUN
bptjm-71	232	24	,	,	PUNCT
bptjm-71	232	25	therapeutic	therapeutic	ADJ
bptjm-71	232	26	strategies	strategy	NOUN
bptjm-71	232	27	targeting	target	VERB
bptjm-71	232	28	senescence	senescence	NOUN
bptjm-71	232	29	offer	offer	NOUN
bptjm-71	232	30	promising	promise	VERB
bptjm-71	232	31	avenues	avenue	NOUN
bptjm-71	232	32	for	for	ADP
bptjm-71	232	33	addressing	address	VERB
bptjm-71	232	34	neurodegenerative	neurodegenerative	ADJ
bptjm-71	232	35	diseases	disease	NOUN
bptjm-71	232	36	.	.	PUNCT
bptjm-71	233	1	senolytics	senolytic	NOUN
bptjm-71	233	2	have	have	AUX
bptjm-71	233	3	shown	show	VERB
bptjm-71	233	4	potential	potential	NOUN
bptjm-71	233	5	in	in	ADP
bptjm-71	233	6	reducing	reduce	VERB
bptjm-71	233	7	neuroinflammation	neuroinflammation	NOUN
bptjm-71	233	8	and	and	CCONJ
bptjm-71	233	9	improving	improve	VERB
bptjm-71	233	10	cognitive	cognitive	ADJ
bptjm-71	233	11	function	function	NOUN
bptjm-71	233	12	,	,	PUNCT
bptjm-71	233	13	while	while	SCONJ
bptjm-71	233	14	senomorphics	senomorphic	NOUN
bptjm-71	233	15	provide	provide	VERB
bptjm-71	233	16	alternatives	alternative	NOUN
bptjm-71	233	17	by	by	ADP
bptjm-71	233	18	modulating	modulate	VERB
bptjm-71	233	19	sasp	sasp	NOUN
bptjm-71	233	20	factors	factor	NOUN
bptjm-71	233	21	without	without	ADP
bptjm-71	233	22	inducing	induce	VERB
bptjm-71	233	23	cell	cell	NOUN
bptjm-71	233	24	death	death	NOUN
bptjm-71	233	25	.	.	PUNCT
bptjm-71	234	1	similarly	similarly	ADV
bptjm-71	234	2	,	,	PUNCT
bptjm-71	234	3	mitochondria	mitochondria	NOUN
bptjm-71	234	4	-	-	PUNCT
bptjm-71	234	5	based	base	VERB
bptjm-71	234	6	therapies	therapy	NOUN
bptjm-71	234	7	hold	hold	VERB
bptjm-71	234	8	promise	promise	NOUN
bptjm-71	234	9	in	in	ADP
bptjm-71	234	10	mitigating	mitigate	VERB
bptjm-71	234	11	oxidative	oxidative	ADJ
bptjm-71	234	12	stress	stress	NOUN
bptjm-71	234	13	and	and	CCONJ
bptjm-71	234	14	enhancing	enhance	VERB
bptjm-71	234	15	cellular	cellular	ADJ
bptjm-71	234	16	health	health	NOUN
bptjm-71	234	17	.	.	PUNCT
bptjm-71	235	1	however	however	ADV
bptjm-71	235	2	,	,	PUNCT
bptjm-71	235	3	challenges	challenge	NOUN
bptjm-71	235	4	remain	remain	VERB
bptjm-71	235	5	in	in	ADP
bptjm-71	235	6	understanding	understand	VERB
bptjm-71	235	7	mechanisms	mechanism	NOUN
bptjm-71	235	8	,	,	PUNCT
bptjm-71	235	9	potential	potential	ADJ
bptjm-71	235	10	side	side	NOUN
bptjm-71	235	11	effects	effect	NOUN
bptjm-71	235	12	,	,	PUNCT
bptjm-71	235	13	and	and	CCONJ
bptjm-71	235	14	disease	disease	NOUN
bptjm-71	235	15	-	-	PUNCT
bptjm-71	235	16	specific	specific	ADJ
bptjm-71	235	17	applications	application	NOUN
bptjm-71	235	18	.	.	PUNCT
bptjm-71	236	1	collaborative	collaborative	ADJ
bptjm-71	236	2	research	research	NOUN
bptjm-71	236	3	across	across	ADP
bptjm-71	236	4	disciplines	discipline	NOUN
bptjm-71	236	5	is	be	AUX
bptjm-71	236	6	vital	vital	ADJ
bptjm-71	236	7	berkeley	berkeley	PROPN
bptjm-71	236	8	pharma	pharma	PROPN
bptjm-71	236	9	tech	tech	NOUN
bptjm-71	236	10	journal	journal	NOUN
bptjm-71	236	11	of	of	ADP
bptjm-71	236	12	medicine	medicine	NOUN
bptjm-71	236	13	|	|	ADV
bptjm-71	236	14	68	68	NUM
bptjm-71	236	15	to	to	PART
bptjm-71	236	16	fully	fully	ADV
bptjm-71	236	17	harness	harness	VERB
bptjm-71	236	18	the	the	DET
bptjm-71	236	19	potential	potential	NOUN
bptjm-71	236	20	of	of	ADP
bptjm-71	236	21	these	these	DET
bptjm-71	236	22	approaches	approach	NOUN
bptjm-71	236	23	and	and	CCONJ
bptjm-71	236	24	reshape	reshape	VERB
bptjm-71	236	25	the	the	DET
bptjm-71	236	26	landscape	landscape	NOUN
bptjm-71	236	27	of	of	ADP
bptjm-71	236	28	neurodegenerative	neurodegenerative	ADJ
bptjm-71	236	29	disease	disease	NOUN
bptjm-71	236	30	treatment	treatment	NOUN
bptjm-71	236	31	.	.	PUNCT
bptjm-71	237	1	berkeley	berkeley	PROPN
bptjm-71	237	2	pharma	pharma	PROPN
bptjm-71	237	3	tech	tech	PROPN
bptjm-71	237	4	journal	journal	NOUN
bptjm-71	237	5	of	of	ADP
bptjm-71	237	6	medicine	medicine	NOUN
bptjm-71	237	7	|	|	ADV
bptjm-71	237	8	69	69	NUM
bptjm-71	237	9	references	reference	NOUN
bptjm-71	237	10	1	1	NUM
bptjm-71	237	11	.	.	PUNCT
bptjm-71	237	12	matsudaira	matsudaira	PROPN
bptjm-71	237	13	t	t	PROPN
bptjm-71	237	14	,	,	PUNCT
bptjm-71	237	15	nakano	nakano	PROPN
bptjm-71	237	16	s	s	PROPN
bptjm-71	237	17	,	,	PUNCT
bptjm-71	237	18	konishi	konishi	PROPN
bptjm-71	237	19	y	y	PROPN
bptjm-71	237	20	,	,	PUNCT
bptjm-71	237	21	et	et	PROPN
bptjm-71	237	22	al	al	PROPN
bptjm-71	237	23	.	.	PUNCT
bptjm-71	238	1	cellular	cellular	ADJ
bptjm-71	238	2	senescence	senescence	NOUN
bptjm-71	238	3	in	in	ADP
bptjm-71	238	4	white	white	ADJ
bptjm-71	238	5	matter	matter	NOUN
bptjm-71	238	6	microglia	microglia	NOUN
bptjm-71	238	7	is	be	AUX
bptjm-71	238	8	induced	induce	VERB
bptjm-71	238	9	during	during	ADP
bptjm-71	238	10	aging	age	VERB
bptjm-71	238	11	in	in	ADP
bptjm-71	238	12	mice	mouse	NOUN
bptjm-71	238	13	and	and	CCONJ
bptjm-71	238	14	exacerbates	exacerbate	VERB
bptjm-71	238	15	the	the	DET
bptjm-71	238	16	neuroinflammatory	neuroinflammatory	ADJ
bptjm-71	238	17	phenotype	phenotype	NOUN
bptjm-71	238	18	.	.	PUNCT
bptjm-71	239	1	commun	commun	PROPN
bptjm-71	239	2	biol	biol	PROPN
bptjm-71	239	3	.	.	PUNCT
bptjm-71	240	1	2023	2023	NUM
bptjm-71	240	2	;	;	PUNCT
bptjm-71	240	3	6(1	6(1	NUM
bptjm-71	240	4	):	):	PUNCT
bptjm-71	241	1	665	665	NUM
bptjm-71	241	2	.	.	PUNCT
bptjm-71	242	1	published	publish	VERB
bptjm-71	242	2	2023	2023	NUM
bptjm-71	242	3	jun	jun	PROPN
bptjm-71	242	4	23	23	NUM
bptjm-71	242	5	.	.	PUNCT
bptjm-71	243	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	243	2	/	/	SYM
bptjm-71	243	3	s42003	s42003	NOUN
bptjm-71	243	4	-	-	PUNCT
bptjm-71	243	5	023	023	NUM
bptjm-71	243	6	-	-	PUNCT
bptjm-71	243	7	05027	05027	NUM
bptjm-71	243	8	-	-	SYM
bptjm-71	243	9	2	2	NUM
bptjm-71	243	10	2	2	NUM
bptjm-71	243	11	.	.	PUNCT
bptjm-71	244	1	ma	ma	PROPN
bptjm-71	244	2	s	s	PROPN
bptjm-71	244	3	,	,	PUNCT
bptjm-71	244	4	xia	xia	PROPN
bptjm-71	244	5	t	t	PROPN
bptjm-71	244	6	,	,	PUNCT
bptjm-71	244	7	wang	wang	PROPN
bptjm-71	244	8	x	x	PROPN
bptjm-71	244	9	,	,	PUNCT
bptjm-71	244	10	wang	wang	PROPN
bptjm-71	244	11	h.	h.	PROPN
bptjm-71	244	12	identification	identification	NOUN
bptjm-71	244	13	and	and	CCONJ
bptjm-71	244	14	validation	validation	NOUN
bptjm-71	244	15	of	of	ADP
bptjm-71	244	16	biomarkers	biomarker	NOUN
bptjm-71	244	17	based	base	VERB
bptjm-71	244	18	on	on	ADP
bptjm-71	244	19	cellular	cellular	ADJ
bptjm-71	244	20	senescence	senescence	NOUN
bptjm-71	244	21	in	in	ADP
bptjm-71	244	22	mild	mild	ADJ
bptjm-71	244	23	cognitive	cognitive	ADJ
bptjm-71	244	24	impairment	impairment	NOUN
bptjm-71	244	25	.	.	PUNCT
bptjm-71	245	1	front	front	ADJ
bptjm-71	245	2	aging	age	VERB
bptjm-71	245	3	neurosci	neurosci	NOUN
bptjm-71	245	4	.	.	PUNCT
bptjm-71	246	1	2023;15:1139789	2023;15:1139789	X
bptjm-71	246	2	.	.	PUNCT
bptjm-71	247	1	published	publish	VERB
bptjm-71	247	2	2023	2023	NUM
bptjm-71	247	3	apr	apr	NOUN
bptjm-71	247	4	28	28	NUM
bptjm-71	247	5	.	.	PUNCT
bptjm-71	248	1	doi:10.3389	doi:10.3389	PROPN
bptjm-71	248	2	/	/	SYM
bptjm-71	248	3	fnagi.2023.1139789	fnagi.2023.1139789	ADV
bptjm-71	248	4	3	3	NUM
bptjm-71	248	5	.	.	PUNCT
bptjm-71	249	1	balasubramanian	balasubramanian	PROPN
bptjm-71	249	2	p	p	PROPN
bptjm-71	249	3	,	,	PUNCT
bptjm-71	249	4	branen	branen	PROPN
bptjm-71	249	5	l	l	PROPN
bptjm-71	249	6	,	,	PUNCT
bptjm-71	249	7	sivasubramanianmk	sivasubramanianmk	NOUN
bptjm-71	249	8	,	,	PUNCT
bptjm-71	249	9	monteiro	monteiro	PROPN
bptjm-71	249	10	r	r	PROPN
bptjm-71	249	11	,	,	PUNCT
bptjm-71	249	12	subramanianm	subramanianm	PROPN
bptjm-71	249	13	.	.	PUNCT
bptjm-71	250	1	aging	aging	NOUN
bptjm-71	250	2	is	be	AUX
bptjm-71	250	3	associated	associate	VERB
bptjm-71	250	4	with	with	ADP
bptjm-71	250	5	glial	glial	ADJ
bptjm-71	250	6	senescence	senescence	NOUN
bptjm-71	250	7	in	in	ADP
bptjm-71	250	8	the	the	DET
bptjm-71	250	9	brainstem	brainstem	NOUN
bptjm-71	250	10	implications	implication	NOUN
bptjm-71	250	11	for	for	ADP
bptjm-71	250	12	age	age	NOUN
bptjm-71	250	13	-	-	PUNCT
bptjm-71	250	14	related	relate	VERB
bptjm-71	250	15	sympathetic	sympathetic	ADJ
bptjm-71	250	16	overactivity	overactivity	NOUN
bptjm-71	250	17	.	.	PUNCT
bptjm-71	251	1	aging	aging	NOUN
bptjm-71	251	2	(	(	PUNCT
bptjm-71	251	3	albany	albany	PROPN
bptjm-71	251	4	ny	ny	PROPN
bptjm-71	251	5	)	)	PUNCT
bptjm-71	251	6	.	.	PUNCT
bptjm-71	252	1	2021	2021	NUM
bptjm-71	252	2	;	;	PUNCT
bptjm-71	252	3	13(10	13(10	NUM
bptjm-71	252	4	):	):	PUNCT
bptjm-71	252	5	13460	13460	NUM
bptjm-71	252	6	-	-	SYM
bptjm-71	252	7	13473	13473	NUM
bptjm-71	252	8	.	.	PUNCT
bptjm-71	253	1	doi:10.18632	doi:10.18632	PROPN
bptjm-71	253	2	/	/	SYM
bptjm-71	253	3	aging.203111	aging.203111	PROPN
bptjm-71	253	4	4	4	NUM
bptjm-71	253	5	.	.	PUNCT
bptjm-71	254	1	ungerleider	ungerleider	PROPN
bptjm-71	254	2	k	k	PROPN
bptjm-71	254	3	,	,	PUNCT
bptjm-71	254	4	beck	beck	PROPN
bptjm-71	254	5	j	j	PROPN
bptjm-71	254	6	,	,	PUNCT
bptjm-71	254	7	lissa	lissa	PROPN
bptjm-71	254	8	d	d	PROPN
bptjm-71	254	9	,	,	PUNCT
bptjm-71	254	10	et	et	PROPN
bptjm-71	254	11	al	al	PROPN
bptjm-71	254	12	.	.	PROPN
bptjm-71	254	13	astrocyte	astrocyte	NOUN
bptjm-71	254	14	senescence	senescence	NOUN
bptjm-71	254	15	and	and	CCONJ
bptjm-71	254	16	sasp	sasp	NOUN
bptjm-71	254	17	in	in	ADP
bptjm-71	254	18	neurodegeneration	neurodegeneration	NOUN
bptjm-71	254	19	:	:	PUNCT
bptjm-71	254	20	tau	tau	PROPN
bptjm-71	254	21	joins	join	VERB
bptjm-71	254	22	the	the	DET
bptjm-71	254	23	loop	loop	NOUN
bptjm-71	254	24	.	.	PUNCT
bptjm-71	255	1	cell	cell	NOUN
bptjm-71	255	2	cycle	cycle	NOUN
bptjm-71	255	3	.	.	PUNCT
bptjm-71	256	1	2021	2021	NUM
bptjm-71	256	2	;	;	PUNCT
bptjm-71	257	1	20(8	20(8	NUM
bptjm-71	257	2	):	):	PUNCT
bptjm-71	257	3	752	752	NUM
bptjm-71	257	4	-	-	SYM
bptjm-71	257	5	764	764	NUM
bptjm-71	257	6	.	.	PUNCT
bptjm-71	258	1	doi:10.1080/15384101.2021.1909260	doi:10.1080/15384101.2021.1909260	PROPN
bptjm-71	258	2	5	5	NUM
bptjm-71	258	3	.	.	PUNCT
bptjm-71	259	1	zhang	zhang	PROPN
bptjm-71	259	2	p	p	PROPN
bptjm-71	259	3	,	,	PUNCT
bptjm-71	259	4	kishimoto	kishimoto	PROPN
bptjm-71	259	5	y	y	PROPN
bptjm-71	259	6	,	,	PUNCT
bptjm-71	259	7	grammatikakis	grammatikakis	PROPN
bptjm-71	259	8	i	i	PRON
bptjm-71	259	9	,	,	PUNCT
bptjm-71	259	10	et	et	PROPN
bptjm-71	259	11	al	al	PROPN
bptjm-71	259	12	.	.	PROPN
bptjm-71	260	1	senolytic	senolytic	PROPN
bptjm-71	260	2	therapy	therapy	NOUN
bptjm-71	260	3	alleviates	alleviate	VERB
bptjm-71	260	4	aβ	aβ	NOUN
bptjm-71	260	5	-	-	PUNCT
bptjm-71	260	6	associated	associate	VERB
bptjm-71	260	7	oligodendrocyte	oligodendrocyte	ADJ
bptjm-71	260	8	progenitor	progenitor	NOUN
bptjm-71	260	9	cell	cell	NOUN
bptjm-71	260	10	senescence	senescence	NOUN
bptjm-71	260	11	and	and	CCONJ
bptjm-71	260	12	cognitive	cognitive	ADJ
bptjm-71	260	13	deficits	deficit	NOUN
bptjm-71	260	14	in	in	ADP
bptjm-71	260	15	an	an	DET
bptjm-71	260	16	alzheimer	alzheimer	NOUN
bptjm-71	260	17	's	's	PART
bptjm-71	260	18	disease	disease	NOUN
bptjm-71	260	19	model.nat	model.nat	X
bptjm-71	260	20	neurosci	neurosci	NOUN
bptjm-71	260	21	.	.	PUNCT
bptjm-71	260	22	2019	2019	NUM
bptjm-71	260	23	;	;	PUNCT
bptjm-71	260	24	22(5	22(5	NOUN
bptjm-71	260	25	):	):	PUNCT
bptjm-71	260	26	719	719	NUM
bptjm-71	260	27	-	-	SYM
bptjm-71	260	28	728	728	NUM
bptjm-71	260	29	.	.	PUNCT
bptjm-71	261	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	261	2	/	/	SYM
bptjm-71	261	3	s41593	s41593	PROPN
bptjm-71	261	4	-	-	PUNCT
bptjm-71	261	5	019	019	NUM
bptjm-71	261	6	-	-	PUNCT
bptjm-71	261	7	0372	0372	NUM
bptjm-71	261	8	-	-	SYM
bptjm-71	261	9	9	9	NUM
bptjm-71	261	10	6	6	NUM
bptjm-71	261	11	.	.	PUNCT
bptjm-71	262	1	bhat	bhat	PROPN
bptjm-71	262	2	r	r	PROPN
bptjm-71	262	3	,	,	PUNCT
bptjm-71	262	4	crowe	crowe	PROPN
bptjm-71	262	5	ep	ep	PROPN
bptjm-71	262	6	,	,	PUNCT
bptjm-71	262	7	bitto	bitto	VERB
bptjm-71	262	8	a	a	PRON
bptjm-71	262	9	,	,	PUNCT
bptjm-71	262	10	et	et	PROPN
bptjm-71	262	11	al	al	PROPN
bptjm-71	262	12	.	.	PROPN
bptjm-71	262	13	astrocyte	astrocyte	NOUN
bptjm-71	262	14	senescence	senescence	NOUN
bptjm-71	262	15	as	as	ADP
bptjm-71	262	16	a	a	DET
bptjm-71	262	17	component	component	NOUN
bptjm-71	262	18	of	of	ADP
bptjm-71	262	19	alzheimer	alzheimer	PROPN
bptjm-71	262	20	's	's	PART
bptjm-71	262	21	disease	disease	NOUN
bptjm-71	262	22	.	.	PUNCT
bptjm-71	263	1	plos	plos	PROPN
bptjm-71	263	2	one	one	NUM
bptjm-71	263	3	.	.	PUNCT
bptjm-71	264	1	2012;7(9):e45069	2012;7(9):e45069	NUM
bptjm-71	264	2	.	.	PUNCT
bptjm-71	264	3	doi:10.1371	doi:10.1371	PROPN
bptjm-71	264	4	/	/	PUNCT
bptjm-71	265	1	journal.pone.0045069	journal.pone.0045069	NOUN
bptjm-71	265	2	7	7	NUM
bptjm-71	265	3	.	.	PUNCT
bptjm-71	265	4	lagoumtzi	lagoumtzi	VERB
bptjm-71	265	5	sm	sm	PROPN
bptjm-71	265	6	,	,	PUNCT
bptjm-71	265	7	chondrogianni	chondrogianni	PROPN
bptjm-71	265	8	n.	n.	PROPN
bptjm-71	265	9	senolytics	senolytic	NOUN
bptjm-71	265	10	and	and	CCONJ
bptjm-71	265	11	senomorphics	senomorphic	NOUN
bptjm-71	265	12	:	:	PUNCT
bptjm-71	265	13	natural	natural	ADJ
bptjm-71	265	14	and	and	CCONJ
bptjm-71	265	15	synthetic	synthetic	ADJ
bptjm-71	265	16	therapeutics	therapeutic	NOUN
bptjm-71	265	17	in	in	ADP
bptjm-71	265	18	the	the	DET
bptjm-71	265	19	treatment	treatment	NOUN
bptjm-71	265	20	of	of	ADP
bptjm-71	265	21	aging	age	VERB
bptjm-71	265	22	and	and	CCONJ
bptjm-71	265	23	chronic	chronic	ADJ
bptjm-71	265	24	diseases	disease	NOUN
bptjm-71	265	25	.	.	PUNCT
bptjm-71	266	1	free	free	ADJ
bptjm-71	266	2	radic	radic	ADJ
bptjm-71	266	3	biol	biol	PROPN
bptjm-71	266	4	med	me	VERB
bptjm-71	266	5	.	.	PUNCT
bptjm-71	266	6	2021	2021	NUM
bptjm-71	266	7	;	;	PUNCT
bptjm-71	266	8	171	171	NUM
bptjm-71	266	9	:	:	SYM
bptjm-71	266	10	169	169	NUM
bptjm-71	266	11	-	-	SYM
bptjm-71	266	12	190	190	NUM
bptjm-71	266	13	.	.	PUNCT
bptjm-71	267	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	267	2	/	/	SYM
bptjm-71	267	3	j.freeradbiomed.2021.05.003	j.freeradbiomed.2021.05.003	PROPN
bptjm-71	267	4	8	8	NUM
bptjm-71	267	5	.	.	PUNCT
bptjm-71	268	1	luís	luí	NOUN
bptjm-71	268	2	c	c	NOUN
bptjm-71	268	3	,	,	PUNCT
bptjm-71	268	4	maduro	maduro	VERB
bptjm-71	268	5	a	a	DET
bptjm-71	268	6	t	t	PROPN
bptjm-71	268	7	,	,	PUNCT
bptjm-71	268	8	pereira	pereira	PROPN
bptjm-71	268	9	p	p	PROPN
bptjm-71	268	10	,	,	PUNCT
bptjm-71	268	11	mendes	mendes	PROPN
bptjm-71	268	12	jj	jj	PROPN
bptjm-71	268	13	,	,	PUNCT
bptjm-71	268	14	soares	soares	PROPN
bptjm-71	268	15	r	r	PROPN
bptjm-71	268	16	,	,	PUNCT
bptjm-71	268	17	ramalho	ramalho	PROPN
bptjm-71	268	18	r.	r.	PROPN
bptjm-71	268	19	nutritional	nutritional	PROPN
bptjm-71	268	20	senolytics	senolytic	NOUN
bptjm-71	268	21	and	and	CCONJ
bptjm-71	268	22	senomorphics	senomorphic	NOUN
bptjm-71	268	23	:	:	PUNCT
bptjm-71	268	24	implications	implication	NOUN
bptjm-71	268	25	to	to	ADP
bptjm-71	268	26	immune	immune	ADJ
bptjm-71	268	27	cells	cell	NOUN
bptjm-71	268	28	metabolism	metabolism	NOUN
bptjm-71	268	29	and	and	CCONJ
bptjm-71	268	30	aging	aging	NOUN
bptjm-71	268	31	from	from	ADP
bptjm-71	268	32	theory	theory	NOUN
bptjm-71	268	33	to	to	ADP
bptjm-71	268	34	practice	practice	NOUN
bptjm-71	268	35	.	.	PUNCT
bptjm-71	269	1	front	front	PROPN
bptjm-71	269	2	nutr	nutr	PROPN
bptjm-71	269	3	..	..	PROPN
bptjm-71	269	4	2022	2022	NUM
bptjm-71	269	5	;	;	PUNCT
bptjm-71	269	6	9	9	NUM
bptjm-71	269	7	:	:	SYM
bptjm-71	269	8	958563	958563	NUM
bptjm-71	269	9	.	.	PUNCT
bptjm-71	270	1	published	publish	VERB
bptjm-71	270	2	2022	2022	NUM
bptjm-71	270	3	sep	sep	NOUN
bptjm-71	270	4	8	8	NUM
bptjm-71	270	5	.	.	PUNCT
bptjm-71	271	1	doi:10.3389	doi:10.3389	PROPN
bptjm-71	271	2	/	/	SYM
bptjm-71	271	3	fnut.2022.958563	fnut.2022.958563	PROPN
bptjm-71	271	4	9	9	NUM
bptjm-71	271	5	.	.	PUNCT
bptjm-71	272	1	herdy	herdy	PROPN
bptjm-71	272	2	jr	jr	PROPN
bptjm-71	272	3	,	,	PUNCT
bptjm-71	272	4	traxler	traxler	NOUN
bptjm-71	272	5	l	l	PROPN
bptjm-71	272	6	,	,	PUNCT
bptjm-71	272	7	agarwal	agarwal	PROPN
bptjm-71	272	8	rk	rk	PRON
bptjm-71	272	9	,	,	PUNCT
bptjm-71	272	10	et	et	PROPN
bptjm-71	272	11	al	al	PROPN
bptjm-71	272	12	.	.	PROPN
bptjm-71	272	13	increased	increase	VERB
bptjm-71	272	14	post	post	ADJ
bptjm-71	272	15	-	-	ADJ
bptjm-71	272	16	mitotic	mitotic	ADJ
bptjm-71	272	17	senescence	senescence	NOUN
bptjm-71	272	18	in	in	ADP
bptjm-71	272	19	aged	aged	ADJ
bptjm-71	272	20	human	human	ADJ
bptjm-71	272	21	neurons	neuron	NOUN
bptjm-71	272	22	is	be	AUX
bptjm-71	272	23	a	a	DET
bptjm-71	272	24	pathological	pathological	ADJ
bptjm-71	272	25	feature	feature	NOUN
bptjm-71	272	26	of	of	ADP
bptjm-71	272	27	alzheimer	alzheimer	PROPN
bptjm-71	272	28	's	's	PART
bptjm-71	272	29	disease	disease	NOUN
bptjm-71	272	30	.	.	PUNCT
bptjm-71	273	1	cell	cell	NOUN
bptjm-71	273	2	stem	stem	NOUN
bptjm-71	273	3	cell	cell	NOUN
bptjm-71	273	4	.	.	PUNCT
bptjm-71	274	1	2022	2022	NUM
bptjm-71	274	2	;	;	PUNCT
bptjm-71	274	3	29(12	29(12	NUM
bptjm-71	274	4	):	):	PUNCT
bptjm-71	274	5	1637	1637	NUM
bptjm-71	274	6	-	-	SYM
bptjm-71	274	7	1652.e6	1652.e6	NUM
bptjm-71	274	8	.	.	PUNCT
bptjm-71	275	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	275	2	/	/	SYM
bptjm-71	275	3	j.stem.2022.11.010	j.stem.2022.11.010	PROPN
bptjm-71	275	4	10	10	NUM
bptjm-71	275	5	.	.	PUNCT
bptjm-71	276	1	salminen	salminen	PROPN
bptjm-71	276	2	a	a	PROPN
bptjm-71	276	3	,	,	PUNCT
bptjm-71	276	4	kauppinen	kauppinen	PROPN
bptjm-71	276	5	a	a	X
bptjm-71	276	6	,	,	PUNCT
bptjm-71	276	7	kaarniranta	kaarniranta	PROPN
bptjm-71	276	8	k.	k.	NOUN
bptjm-71	276	9	emerging	emerge	VERB
bptjm-71	276	10	role	role	NOUN
bptjm-71	276	11	of	of	ADP
bptjm-71	276	12	nf	nf	ADJ
bptjm-71	276	13	-	-	PUNCT
bptjm-71	276	14	κb	κb	NOUN
bptjm-71	276	15	signaling	signal	VERB
bptjm-71	276	16	in	in	ADP
bptjm-71	276	17	the	the	DET
bptjm-71	276	18	induction	induction	NOUN
bptjm-71	276	19	of	of	ADP
bptjm-71	276	20	senescence	senescence	NOUN
bptjm-71	276	21	-	-	PUNCT
bptjm-71	276	22	associated	associate	VERB
bptjm-71	276	23	secretory	secretory	ADJ
bptjm-71	276	24	phenotype	phenotype	NOUN
bptjm-71	276	25	(	(	PUNCT
bptjm-71	276	26	sasp	sasp	NOUN
bptjm-71	276	27	)	)	PUNCT
bptjm-71	276	28	.	.	PUNCT
bptjm-71	277	1	cell	cell	NOUN
bptjm-71	277	2	signal	signal	NOUN
bptjm-71	277	3	.	.	PUNCT
bptjm-71	278	1	2012	2012	NUM
bptjm-71	278	2	;	;	PUNCT
bptjm-71	278	3	24(4	24(4	NUM
bptjm-71	278	4	):	):	PUNCT
bptjm-71	278	5	835	835	NUM
bptjm-71	278	6	-	-	SYM
bptjm-71	278	7	845	845	NUM
bptjm-71	278	8	.	.	PUNCT
bptjm-71	278	9	doi:10.1016	doi:10.1016	PROPN
bptjm-71	278	10	/	/	SYM
bptjm-71	278	11	j.cellsig.2011.12.006	j.cellsig.2011.12.006	PROPN
bptjm-71	278	12	11	11	NUM
bptjm-71	278	13	.	.	PUNCT
bptjm-71	279	1	jiang	jiang	PROPN
bptjm-71	279	2	cs	cs	PROPN
bptjm-71	279	3	,	,	PUNCT
bptjm-71	279	4	rana	rana	PROPN
bptjm-71	279	5	t	t	PROPN
bptjm-71	279	6	,	,	PUNCT
bptjm-71	279	7	jin	jin	PROPN
bptjm-71	279	8	lw	lw	PROPN
bptjm-71	279	9	,	,	PUNCT
bptjm-71	279	10	et	et	PROPN
bptjm-71	279	11	al	al	PROPN
bptjm-71	279	12	.	.	PROPN
bptjm-71	279	13	aging	aging	NOUN
bptjm-71	279	14	,	,	PUNCT
bptjm-71	279	15	plasminogen	plasminogen	NOUN
bptjm-71	279	16	activator	activator	NOUN
bptjm-71	279	17	inhibitor	inhibitor	NOUN
bptjm-71	279	18	1	1	NUM
bptjm-71	279	19	,	,	PUNCT
bptjm-71	279	20	brain	brain	NOUN
bptjm-71	279	21	cell	cell	NOUN
bptjm-71	279	22	senescence	senescence	NOUN
bptjm-71	279	23	,	,	PUNCT
bptjm-71	279	24	and	and	CCONJ
bptjm-71	279	25	alzheimer	alzheimer	PROPN
bptjm-71	279	26	's	's	PART
bptjm-71	279	27	disease	disease	NOUN
bptjm-71	279	28	.	.	PUNCT
bptjm-71	280	1	aging	age	VERB
bptjm-71	280	2	dis	dis	PROPN
bptjm-71	280	3	.	.	PUNCT
bptjm-71	280	4	2023	2023	NUM
bptjm-71	280	5	;	;	PUNCT
bptjm-71	281	1	14(2	14(2	NUM
bptjm-71	281	2	):	):	PUNCT
bptjm-71	281	3	515	515	NUM
bptjm-71	281	4	-	-	SYM
bptjm-71	281	5	528	528	NUM
bptjm-71	281	6	.	.	PUNCT
bptjm-71	282	1	published	publish	VERB
bptjm-71	282	2	2023	2023	NUM
bptjm-71	282	3	apr	apr	NOUN
bptjm-71	282	4	1	1	NUM
bptjm-71	282	5	.	.	PUNCT
bptjm-71	282	6	doi:10.14336	doi:10.14336	NOUN
bptjm-71	282	7	/	/	SYM
bptjm-71	282	8	ad.2022.1220	ad.2022.1220	NOUN
bptjm-71	282	9	12	12	NUM
bptjm-71	282	10	.	.	PUNCT
bptjm-71	283	1	zhou	zhou	PROPN
bptjm-71	283	2	l	l	PROPN
bptjm-71	283	3	,	,	PUNCT
bptjm-71	283	4	kong	kong	PROPN
bptjm-71	283	5	g	g	PROPN
bptjm-71	283	6	,	,	PUNCT
bptjm-71	283	7	palmisano	palmisano	INTJ
bptjm-71	283	8	i	i	PRON
bptjm-71	283	9	,	,	PUNCT
bptjm-71	283	10	et	et	PROPN
bptjm-71	283	11	al	al	PROPN
bptjm-71	283	12	.	.	PUNCT
bptjm-71	284	1	reversible	reversible	ADJ
bptjm-71	284	2	cd8	cd8	PROPN
bptjm-71	284	3	t	t	PROPN
bptjm-71	284	4	cell	cell	NOUN
bptjm-71	284	5	-	-	PUNCT
bptjm-71	284	6	neuron	neuron	NOUN
bptjm-71	284	7	cross	cross	ADJ
bptjm-71	284	8	-	-	ADJ
bptjm-71	284	9	talk	talk	ADJ
bptjm-71	284	10	causes	cause	VERB
bptjm-71	284	11	aging	age	VERB
bptjm-71	284	12	-	-	PUNCT
bptjm-71	284	13	dependent	dependent	ADJ
bptjm-71	284	14	neuronal	neuronal	ADJ
bptjm-71	284	15	regenerative	regenerative	ADJ
bptjm-71	284	16	decline	decline	NOUN
bptjm-71	284	17	.	.	PUNCT
bptjm-71	285	1	science	science	NOUN
bptjm-71	285	2	.	.	PUNCT
bptjm-71	286	1	2022	2022	NUM
bptjm-71	286	2	;	;	PUNCT
bptjm-71	286	3	376(6594	376(6594	NUM
bptjm-71	286	4	):	):	PUNCT
bptjm-71	286	5	eabd5926	eabd5926	PROPN
bptjm-71	286	6	.	.	PUNCT
bptjm-71	287	1	doi:10.1126	doi:10.1126	PROPN
bptjm-71	287	2	/	/	SYM
bptjm-71	287	3	science.abd5926	science.abd5926	NOUN
bptjm-71	287	4	13	13	NUM
bptjm-71	287	5	.	.	PUNCT
bptjm-71	288	1	kaya	kaya	PROPN
bptjm-71	288	2	t	t	PROPN
bptjm-71	288	3	,	,	PUNCT
bptjm-71	288	4	mattugini	mattugini	PROPN
bptjm-71	288	5	n	n	CCONJ
bptjm-71	288	6	,	,	PUNCT
bptjm-71	288	7	liu	liu	PROPN
bptjm-71	288	8	l	l	PROPN
bptjm-71	288	9	,	,	PUNCT
bptjm-71	288	10	et	et	PROPN
bptjm-71	288	11	al	al	PROPN
bptjm-71	288	12	.	.	PUNCT
bptjm-71	289	1	cd8	cd8	PROPN
bptjm-71	289	2	+	+	PROPN
bptjm-71	289	3	t	t	NOUN
bptjm-71	289	4	cells	cell	NOUN
bptjm-71	289	5	induce	induce	VERB
bptjm-71	289	6	interferon	interferon	ADJ
bptjm-71	289	7	-	-	PUNCT
bptjm-71	289	8	responsive	responsive	ADJ
bptjm-71	289	9	oligodendrocytes	oligodendrocyte	NOUN
bptjm-71	289	10	and	and	CCONJ
bptjm-71	289	11	microglia	microglia	NOUN
bptjm-71	289	12	in	in	ADP
bptjm-71	289	13	white	white	ADJ
bptjm-71	289	14	matter	matter	PROPN
bptjm-71	289	15	aging.nat	aging.nat	PROPN
bptjm-71	289	16	neurosci	neurosci	PROPN
bptjm-71	289	17	.	.	PUNCT
bptjm-71	289	18	2022	2022	NUM
bptjm-71	289	19	;	;	PUNCT
bptjm-71	289	20	25(11):1446	25(11):1446	NUM
bptjm-71	289	21	-	-	SYM
bptjm-71	289	22	1457	1457	NUM
bptjm-71	289	23	.	.	PUNCT
bptjm-71	290	1	berkeley	berkeley	PROPN
bptjm-71	290	2	pharma	pharma	PROPN
bptjm-71	290	3	tech	tech	PROPN
bptjm-71	290	4	journal	journal	NOUN
bptjm-71	290	5	of	of	ADP
bptjm-71	290	6	medicine	medicine	NOUN
bptjm-71	290	7	|70	|70	NOUN
bptjm-71	290	8	doi:10.1038	doi:10.1038	NOUN
bptjm-71	290	9	/	/	SYM
bptjm-71	290	10	s41593	s41593	PROPN
bptjm-71	290	11	-	-	PUNCT
bptjm-71	290	12	022	022	NUM
bptjm-71	290	13	-	-	PUNCT
bptjm-71	290	14	01183	01183	NUM
bptjm-71	290	15	-	-	SYM
bptjm-71	290	16	6	6	NUM
bptjm-71	290	17	14	14	NUM
bptjm-71	290	18	.	.	PUNCT
bptjm-71	291	1	schlett	schlett	PROPN
bptjm-71	291	2	js	js	PROPN
bptjm-71	291	3	,	,	PUNCT
bptjm-71	291	4	mettangm	mettangm	NOUN
bptjm-71	291	5	,	,	PUNCT
bptjm-71	291	6	skaf	skaf	NOUN
bptjm-71	291	7	a	a	PRON
bptjm-71	291	8	,	,	PUNCT
bptjm-71	291	9	et	et	PROPN
bptjm-71	291	10	al	al	PROPN
bptjm-71	291	11	.	.	PROPN
bptjm-71	291	12	nf	nf	PROPN
bptjm-71	291	13	-	-	PUNCT
bptjm-71	291	14	κb	κb	PROPN
bptjm-71	291	15	is	be	AUX
bptjm-71	291	16	a	a	DET
bptjm-71	291	17	critical	critical	ADJ
bptjm-71	291	18	mediator	mediator	NOUN
bptjm-71	291	19	of	of	ADP
bptjm-71	291	20	post	post	ADJ
bptjm-71	291	21	-	-	ADJ
bptjm-71	291	22	mitotic	mitotic	ADJ
bptjm-71	291	23	senescence	senescence	NOUN
bptjm-71	291	24	in	in	ADP
bptjm-71	291	25	oligodendrocytes	oligodendrocyte	NOUN
bptjm-71	291	26	and	and	CCONJ
bptjm-71	291	27	subsequent	subsequent	ADJ
bptjm-71	291	28	white	white	ADJ
bptjm-71	291	29	matter	matter	NOUN
bptjm-71	291	30	loss.mol	loss.mol	X
bptjm-71	291	31	neurodegener	neurodegener	NOUN
bptjm-71	291	32	.	.	PUNCT
bptjm-71	292	1	2023	2023	NUM
bptjm-71	292	2	;	;	PUNCT
bptjm-71	292	3	18(1	18(1	NUM
bptjm-71	292	4	):	):	PUNCT
bptjm-71	292	5	24	24	NUM
bptjm-71	292	6	.	.	PUNCT
bptjm-71	293	1	published	publish	VERB
bptjm-71	293	2	2023	2023	NUM
bptjm-71	293	3	apr	apr	NOUN
bptjm-71	293	4	17	17	NUM
bptjm-71	293	5	.	.	PUNCT
bptjm-71	294	1	doi:10.1186	doi:10.1186	PROPN
bptjm-71	294	2	/	/	SYM
bptjm-71	294	3	s13024	s13024	VERB
bptjm-71	294	4	-	-	PUNCT
bptjm-71	294	5	023	023	NUM
bptjm-71	294	6	-	-	PUNCT
bptjm-71	294	7	00616	00616	NUM
bptjm-71	294	8	-	-	SYM
bptjm-71	294	9	5	5	NUM
bptjm-71	294	10	15	15	NUM
bptjm-71	294	11	.	.	PUNCT
bptjm-71	295	1	rouillard	rouillard	VERB
bptjm-71	295	2	me	i	PRON
bptjm-71	295	3	,	,	PUNCT
bptjm-71	295	4	hu	hu	PROPN
bptjm-71	295	5	j	j	PROPN
bptjm-71	295	6	,	,	PUNCT
bptjm-71	295	7	sutter	sutter	PROPN
bptjm-71	295	8	pa	pa	PROPN
bptjm-71	295	9	,	,	PUNCT
bptjm-71	295	10	kimhw	kimhw	PROPN
bptjm-71	295	11	,	,	PUNCT
bptjm-71	295	12	huang	huang	PROPN
bptjm-71	295	13	jk	jk	PROPN
bptjm-71	295	14	,	,	PUNCT
bptjm-71	295	15	crocker	crocker	PROPN
bptjm-71	295	16	sj	sj	PROPN
bptjm-71	295	17	.	.	PUNCT
bptjm-71	296	1	the	the	DET
bptjm-71	296	2	cellular	cellular	ADJ
bptjm-71	296	3	senescence	senescence	NOUN
bptjm-71	296	4	factor	factor	NOUN
bptjm-71	296	5	extracellular	extracellular	ADJ
bptjm-71	296	6	hmgb1	hmgb1	PROPN
bptjm-71	296	7	directly	directly	ADV
bptjm-71	296	8	inhibits	inhibit	VERB
bptjm-71	296	9	oligodendrocyte	oligodendrocyte	ADJ
bptjm-71	296	10	progenitor	progenitor	NOUN
bptjm-71	296	11	cell	cell	NOUN
bptjm-71	296	12	differentiation	differentiation	NOUN
bptjm-71	296	13	and	and	CCONJ
bptjm-71	296	14	impairs	impair	VERB
bptjm-71	296	15	cns	cns	NOUN
bptjm-71	296	16	remyelination	remyelination	NOUN
bptjm-71	296	17	.	.	PUNCT
bptjm-71	297	1	front	front	ADJ
bptjm-71	297	2	cell	cell	NOUN
bptjm-71	297	3	neurosci	neurosci	NOUN
bptjm-71	297	4	.	.	PUNCT
bptjm-71	298	1	2022	2022	NUM
bptjm-71	298	2	;	;	PUNCT
bptjm-71	298	3	16	16	NUM
bptjm-71	298	4	:	:	SYM
bptjm-71	298	5	833186	833186	NUM
bptjm-71	298	6	.	.	PUNCT
bptjm-71	299	1	published	publish	VERB
bptjm-71	299	2	2022	2022	NUM
bptjm-71	299	3	apr	apr	NOUN
bptjm-71	299	4	28	28	NUM
bptjm-71	299	5	.	.	PUNCT
bptjm-71	300	1	doi:10.3389	doi:10.3389	PROPN
bptjm-71	300	2	/	/	SYM
bptjm-71	300	3	fncel.2022.833186	fncel.2022.833186	PROPN
bptjm-71	300	4	16	16	NUM
bptjm-71	300	5	.	.	PUNCT
bptjm-71	301	1	nicaise	nicaise	PROPN
bptjm-71	301	2	am	am	PROPN
bptjm-71	301	3	,	,	PUNCT
bptjm-71	301	4	wagstaff	wagstaff	PROPN
bptjm-71	301	5	lj	lj	PROPN
bptjm-71	301	6	,	,	PUNCT
bptjm-71	301	7	willis	willis	PROPN
bptjm-71	301	8	cm	cm	PROPN
bptjm-71	301	9	,	,	PUNCT
bptjm-71	301	10	et	et	PROPN
bptjm-71	301	11	al	al	PROPN
bptjm-71	301	12	.	.	PUNCT
bptjm-71	301	13	cellular	cellular	ADJ
bptjm-71	301	14	senescence	senescence	NOUN
bptjm-71	301	15	in	in	ADP
bptjm-71	301	16	progenitor	progenitor	NOUN
bptjm-71	301	17	cells	cell	NOUN
bptjm-71	301	18	contributes	contribute	VERB
bptjm-71	301	19	to	to	ADP
bptjm-71	301	20	diminished	diminished	ADJ
bptjm-71	301	21	remyelination	remyelination	NOUN
bptjm-71	301	22	potential	potential	NOUN
bptjm-71	301	23	in	in	ADP
bptjm-71	301	24	progressive	progressive	ADJ
bptjm-71	301	25	multiple	multiple	ADJ
bptjm-71	301	26	sclerosis	sclerosis	NOUN
bptjm-71	301	27	.	.	PUNCT
bptjm-71	302	1	proc	proc	PROPN
bptjm-71	302	2	natl	natl	PROPN
bptjm-71	302	3	acad	acad	PROPN
bptjm-71	302	4	sci	sci	PROPN
bptjm-71	302	5	u	u	PROPN
bptjm-71	302	6	s	s	PROPN
bptjm-71	302	7	a.	a.	NOUN
bptjm-71	302	8	2019	2019	NUM
bptjm-71	302	9	;	;	PUNCT
bptjm-71	302	10	116(18	116(18	NUM
bptjm-71	302	11	):	):	PUNCT
bptjm-71	302	12	9030	9030	NUM
bptjm-71	302	13	-	-	SYM
bptjm-71	302	14	9039	9039	NUM
bptjm-71	302	15	.	.	PUNCT
bptjm-71	303	1	doi:10.1073	doi:10.1073	NOUN
bptjm-71	303	2	/	/	SYM
bptjm-71	304	1	pnas.1818348116	pnas.1818348116	ADJ
bptjm-71	304	2	17	17	NUM
bptjm-71	304	3	.	.	PUNCT
bptjm-71	305	1	severino	severino	PROPN
bptjm-71	305	2	j	j	PROPN
bptjm-71	305	3	,	,	PUNCT
bptjm-71	305	4	allen	allen	PROPN
bptjm-71	305	5	rg	rg	PROPN
bptjm-71	305	6	,	,	PUNCT
bptjm-71	305	7	balin	balin	PROPN
bptjm-71	305	8	s	s	PROPN
bptjm-71	305	9	,	,	PUNCT
bptjm-71	305	10	balin	balin	PROPN
bptjm-71	305	11	a	a	PROPN
bptjm-71	305	12	,	,	PUNCT
bptjm-71	305	13	cristofalo	cristofalo	PROPN
bptjm-71	305	14	vj	vj	PROPN
bptjm-71	305	15	.	.	PROPN
bptjm-71	305	16	is	be	AUX
bptjm-71	305	17	beta	beta	NOUN
bptjm-71	305	18	-	-	PUNCT
bptjm-71	305	19	galactosidase	galactosidase	NOUN
bptjm-71	305	20	staining	stain	VERB
bptjm-71	305	21	a	a	DET
bptjm-71	305	22	marker	marker	NOUN
bptjm-71	305	23	of	of	ADP
bptjm-71	305	24	senescence	senescence	NOUN
bptjm-71	305	25	in	in	ADP
bptjm-71	305	26	vitro	vitro	X
bptjm-71	305	27	and	and	CCONJ
bptjm-71	305	28	in	in	ADP
bptjm-71	305	29	vivo	vivo	NOUN
bptjm-71	305	30	?	?	PUNCT
bptjm-71	306	1	exp	exp	NOUN
bptjm-71	306	2	cell	cell	NOUN
bptjm-71	306	3	res	re	NOUN
bptjm-71	306	4	.	.	PUNCT
bptjm-71	306	5	2000	2000	NUM
bptjm-71	306	6	;	;	PUNCT
bptjm-71	306	7	257(1	257(1	NUM
bptjm-71	306	8	):	):	PUNCT
bptjm-71	306	9	162	162	NUM
bptjm-71	306	10	-	-	SYM
bptjm-71	306	11	171	171	NUM
bptjm-71	306	12	.	.	PUNCT
bptjm-71	307	1	doi:10.1006	doi:10.1006	PROPN
bptjm-71	307	2	/	/	SYM
bptjm-71	307	3	excr.2000.4875	excr.2000.4875	PROPN
bptjm-71	307	4	18	18	NUM
bptjm-71	307	5	.	.	PUNCT
bptjm-71	308	1	rebbaa	rebbaa	PROPN
bptjm-71	308	2	a	a	PROPN
bptjm-71	308	3	,	,	PUNCT
bptjm-71	308	4	zheng	zheng	PROPN
bptjm-71	308	5	x	x	PROPN
bptjm-71	308	6	,	,	PUNCT
bptjm-71	308	7	chou	chou	PROPN
bptjm-71	308	8	pm	pm	NOUN
bptjm-71	308	9	,	,	PUNCT
bptjm-71	308	10	mirkin	mirkin	ADV
bptjm-71	308	11	bl	bl	PROPN
bptjm-71	308	12	.	.	PUNCT
bptjm-71	309	1	caspase	caspase	PROPN
bptjm-71	309	2	inhibition	inhibition	VERB
bptjm-71	309	3	switches	switch	VERB
bptjm-71	309	4	doxorubicin	doxorubicin	PROPN
bptjm-71	309	5	-	-	PUNCT
bptjm-71	309	6	induced	induce	VERB
bptjm-71	309	7	apoptosis	apoptosis	NOUN
bptjm-71	309	8	to	to	ADP
bptjm-71	309	9	senescence.oncogene	senescence.oncogene	NUM
bptjm-71	309	10	.	.	PUNCT
bptjm-71	309	11	2003	2003	NUM
bptjm-71	309	12	;	;	PUNCT
bptjm-71	309	13	22(18	22(18	NUM
bptjm-71	309	14	):	):	PUNCT
bptjm-71	309	15	2805	2805	NUM
bptjm-71	309	16	-	-	SYM
bptjm-71	309	17	2811	2811	NUM
bptjm-71	309	18	.	.	PUNCT
bptjm-71	310	1	doi:10.1038	doi:10.1038	PROPN
bptjm-71	310	2	/	/	SYM
bptjm-71	310	3	sj.onc.1206366	sj.onc.1206366	PROPN
bptjm-71	310	4	19	19	NUM
bptjm-71	310	5	.	.	PUNCT
bptjm-71	311	1	jin	jin	PROPN
bptjm-71	311	2	wn	wn	PROPN
bptjm-71	311	3	,	,	PUNCT
bptjm-71	311	4	shi	shi	PROPN
bptjm-71	311	5	k	k	PROPN
bptjm-71	311	6	,	,	PUNCT
bptjm-71	311	7	hew	hew	VERB
bptjm-71	311	8	,	,	PUNCT
bptjm-71	311	9	et	et	PROPN
bptjm-71	311	10	al	al	PROPN
bptjm-71	311	11	.	.	PROPN
bptjm-71	311	12	neuroblast	neuroblast	PROPN
bptjm-71	311	13	senescence	senescence	NOUN
bptjm-71	311	14	in	in	ADP
bptjm-71	311	15	the	the	DET
bptjm-71	311	16	aged	aged	ADJ
bptjm-71	311	17	brain	brain	NOUN
bptjm-71	311	18	augments	augment	VERB
bptjm-71	311	19	natural	natural	ADJ
bptjm-71	311	20	killer	killer	NOUN
bptjm-71	311	21	cell	cell	NOUN
bptjm-71	311	22	cytotoxicity	cytotoxicity	NOUN
bptjm-71	311	23	leading	lead	VERB
bptjm-71	311	24	to	to	ADP
bptjm-71	311	25	impaired	impaired	ADJ
bptjm-71	311	26	neurogenesis	neurogenesis	NOUN
bptjm-71	311	27	and	and	CCONJ
bptjm-71	311	28	cognition.nat	cognition.nat	NOUN
bptjm-71	311	29	neurosci	neurosci	NOUN
bptjm-71	311	30	.	.	PUNCT
bptjm-71	312	1	2021	2021	NUM
bptjm-71	312	2	;	;	PUNCT
bptjm-71	312	3	24(1	24(1	NUM
bptjm-71	312	4	):	):	PUNCT
bptjm-71	312	5	61	61	NUM
bptjm-71	312	6	-	-	SYM
bptjm-71	312	7	73	73	NUM
bptjm-71	312	8	.	.	PUNCT
bptjm-71	313	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	313	2	/	/	SYM
bptjm-71	313	3	s41593	s41593	PROPN
bptjm-71	313	4	-	-	PUNCT
bptjm-71	313	5	020	020	NUM
bptjm-71	313	6	-	-	PUNCT
bptjm-71	313	7	00745	00745	NUM
bptjm-71	313	8	-	-	PUNCT
bptjm-71	313	9	w	w	PROPN
bptjm-71	313	10	20	20	NUM
bptjm-71	313	11	.	.	PUNCT
bptjm-71	314	1	bussian	bussian	PROPN
bptjm-71	314	2	tj	tj	PROPN
bptjm-71	314	3	,	,	PUNCT
bptjm-71	314	4	aziz	aziz	PROPN
bptjm-71	314	5	a	a	PROPN
bptjm-71	314	6	,	,	PUNCT
bptjm-71	314	7	meyer	meyer	PROPN
bptjm-71	314	8	cf	cf	PROPN
bptjm-71	314	9	,	,	PUNCT
bptjm-71	314	10	swenson	swenson	PROPN
bptjm-71	314	11	bl	bl	PROPN
bptjm-71	314	12	,	,	PUNCT
bptjm-71	314	13	van	van	PROPN
bptjm-71	314	14	deursen	deursen	PROPN
bptjm-71	314	15	jm	jm	PROPN
bptjm-71	314	16	,	,	PUNCT
bptjm-71	314	17	baker	baker	PROPN
bptjm-71	314	18	dj	dj	PROPN
bptjm-71	314	19	.	.	PUNCT
bptjm-71	315	1	clearance	clearance	NOUN
bptjm-71	315	2	of	of	ADP
bptjm-71	315	3	senescent	senescent	ADJ
bptjm-71	315	4	glial	glial	ADJ
bptjm-71	315	5	cells	cell	NOUN
bptjm-71	315	6	prevents	prevent	VERB
bptjm-71	315	7	tau	tau	PROPN
bptjm-71	315	8	-	-	PUNCT
bptjm-71	315	9	dependent	dependent	ADJ
bptjm-71	315	10	pathology	pathology	NOUN
bptjm-71	315	11	and	and	CCONJ
bptjm-71	315	12	cognitive	cognitive	ADJ
bptjm-71	315	13	decline.nature	decline.nature	NOUN
bptjm-71	315	14	.	.	PUNCT
bptjm-71	315	15	2018	2018	NUM
bptjm-71	315	16	;	;	PUNCT
bptjm-71	316	1	562(7728	562(7728	NUM
bptjm-71	316	2	):	):	PUNCT
bptjm-71	316	3	578	578	NUM
bptjm-71	316	4	-	-	SYM
bptjm-71	316	5	582	582	NUM
bptjm-71	316	6	.	.	PUNCT
bptjm-71	316	7	doi:10.1038	doi:10.1038	NOUN
bptjm-71	316	8	/	/	SYM
bptjm-71	316	9	s41586	s41586	PROPN
bptjm-71	316	10	-	-	PUNCT
bptjm-71	316	11	018	018	NUM
bptjm-71	316	12	-	-	PUNCT
bptjm-71	316	13	0543	0543	NUM
bptjm-71	316	14	-	-	PUNCT
bptjm-71	316	15	y	y	PROPN
bptjm-71	316	16	21	21	NUM
bptjm-71	316	17	.	.	PUNCT
bptjm-71	317	1	musi	musi	PROPN
bptjm-71	317	2	n	n	CCONJ
bptjm-71	317	3	,	,	PUNCT
bptjm-71	317	4	v	v	ADP
bptjm-71	317	5	alentine	alentine	PROPN
bptjm-71	317	6	jm	jm	PROPN
bptjm-71	317	7	,	,	PUNCT
bptjm-71	317	8	sickora	sickora	PROPN
bptjm-71	317	9	kr	kr	PROPN
bptjm-71	317	10	,	,	PUNCT
bptjm-71	317	11	et	et	PROPN
bptjm-71	317	12	al	al	PROPN
bptjm-71	317	13	.	.	PUNCT
bptjm-71	318	1	tau	tau	PROPN
bptjm-71	318	2	protein	protein	NOUN
bptjm-71	318	3	aggregation	aggregation	NOUN
bptjm-71	318	4	is	be	AUX
bptjm-71	318	5	associated	associate	VERB
bptjm-71	318	6	with	with	ADP
bptjm-71	318	7	cellular	cellular	ADJ
bptjm-71	318	8	senescence	senescence	NOUN
bptjm-71	318	9	in	in	ADP
bptjm-71	318	10	the	the	DET
bptjm-71	318	11	brain	brain	NOUN
bptjm-71	318	12	.	.	PUNCT
bptjm-71	319	1	aging	age	VERB
bptjm-71	319	2	cell	cell	NOUN
bptjm-71	319	3	.	.	PUNCT
bptjm-71	320	1	2018	2018	NUM
bptjm-71	320	2	;	;	PUNCT
bptjm-71	320	3	17(6	17(6	NUM
bptjm-71	320	4	):	):	PUNCT
bptjm-71	320	5	e12840	e12840	NOUN
bptjm-71	320	6	.	.	PUNCT
bptjm-71	321	1	doi:10.1111	doi:10.1111	PROPN
bptjm-71	321	2	/	/	SYM
bptjm-71	322	1	acel.12840	acel.12840	PROPN
bptjm-71	322	2	22	22	NUM
bptjm-71	322	3	.	.	PUNCT
bptjm-71	322	4	bettcher	bettcher	PROPN
bptjm-71	322	5	bm	bm	PROPN
bptjm-71	322	6	,	,	PUNCT
bptjm-71	322	7	neuhaus	neuhaus	PROPN
bptjm-71	322	8	j	j	PROPN
bptjm-71	322	9	,	,	PUNCT
bptjm-71	322	10	wynnmj	wynnmj	PROPN
bptjm-71	322	11	,	,	PUNCT
bptjm-71	322	12	et	et	PROPN
bptjm-71	322	13	al	al	PROPN
bptjm-71	322	14	.	.	PROPN
bptjm-71	322	15	increases	increase	VERB
bptjm-71	322	16	in	in	ADP
bptjm-71	322	17	a	a	DET
bptjm-71	322	18	pro	pro	ADJ
bptjm-71	322	19	-	-	ADJ
bptjm-71	322	20	inflammatory	inflammatory	ADJ
bptjm-71	322	21	chemokine	chemokine	ADJ
bptjm-71	322	22	,	,	PUNCT
bptjm-71	322	23	mcp-1	mcp-1	NOUN
bptjm-71	322	24	,	,	PUNCT
bptjm-71	322	25	are	be	AUX
bptjm-71	322	26	related	relate	VERB
bptjm-71	322	27	to	to	ADP
bptjm-71	322	28	decreases	decrease	NOUN
bptjm-71	322	29	in	in	ADP
bptjm-71	322	30	memory	memory	NOUN
bptjm-71	322	31	over	over	ADP
bptjm-71	322	32	time	time	NOUN
bptjm-71	322	33	.	.	PUNCT
bptjm-71	323	1	front	front	ADJ
bptjm-71	323	2	aging	age	VERB
bptjm-71	323	3	neurosci	neurosci	NOUN
bptjm-71	323	4	.	.	PUNCT
bptjm-71	324	1	2019	2019	NUM
bptjm-71	324	2	;	;	PUNCT
bptjm-71	325	1	11	11	NUM
bptjm-71	325	2	:	:	SYM
bptjm-71	325	3	25	25	NUM
bptjm-71	325	4	.	.	PUNCT
bptjm-71	325	5	published	publish	VERB
bptjm-71	325	6	2019	2019	NUM
bptjm-71	325	7	feb	feb	NOUN
bptjm-71	325	8	13	13	NUM
bptjm-71	325	9	.	.	PUNCT
bptjm-71	325	10	doi:10.3389	doi:10.3389	NOUN
bptjm-71	325	11	/	/	SYM
bptjm-71	325	12	fnagi.2019.00025	fnagi.2019.00025	PROPN
bptjm-71	325	13	23	23	NUM
bptjm-71	325	14	.	.	PUNCT
bptjm-71	326	1	li	li	PROPN
bptjm-71	326	2	y	y	PROPN
bptjm-71	326	3	,	,	PUNCT
bptjm-71	326	4	lu	lu	PROPN
bptjm-71	326	5	j	j	PROPN
bptjm-71	326	6	,	,	PUNCT
bptjm-71	326	7	hou	hou	PROPN
bptjm-71	326	8	y	y	PROPN
bptjm-71	326	9	,	,	PUNCT
bptjm-71	326	10	huang	huang	PROPN
bptjm-71	326	11	s	s	PROPN
bptjm-71	326	12	,	,	PUNCT
bptjm-71	326	13	pei	pei	PROPN
bptjm-71	326	14	g.	g.	PROPN
bptjm-71	326	15	alzheimer	alzheimer	PROPN
bptjm-71	326	16	's	's	PART
bptjm-71	326	17	amyloid	amyloid	NOUN
bptjm-71	326	18	-	-	PUNCT
bptjm-71	326	19	β	β	NOUN
bptjm-71	326	20	accelerates	accelerate	VERB
bptjm-71	326	21	human	human	ADJ
bptjm-71	326	22	neuronal	neuronal	ADJ
bptjm-71	326	23	cell	cell	NOUN
bptjm-71	326	24	senescence	senescence	NOUN
bptjm-71	326	25	which	which	PRON
bptjm-71	326	26	could	could	AUX
bptjm-71	326	27	be	be	AUX
bptjm-71	326	28	rescued	rescue	VERB
bptjm-71	326	29	by	by	ADP
bptjm-71	326	30	sirtuin-1	sirtuin-1	NOUN
bptjm-71	326	31	and	and	CCONJ
bptjm-71	326	32	aspirin	aspirin	NOUN
bptjm-71	326	33	.	.	PUNCT
bptjm-71	327	1	front	front	ADJ
bptjm-71	327	2	cell	cell	NOUN
bptjm-71	327	3	neurosci	neurosci	NOUN
bptjm-71	327	4	.	.	PUNCT
bptjm-71	328	1	2022	2022	NUM
bptjm-71	328	2	;	;	PUNCT
bptjm-71	328	3	16	16	NUM
bptjm-71	328	4	:	:	SYM
bptjm-71	328	5	906270	906270	NUM
bptjm-71	328	6	.	.	PUNCT
bptjm-71	329	1	published	publish	VERB
bptjm-71	329	2	2022	2022	NUM
bptjm-71	329	3	jun	jun	PROPN
bptjm-71	329	4	17	17	NUM
bptjm-71	329	5	.	.	PUNCT
bptjm-71	330	1	doi:10.3389	doi:10.3389	PROPN
bptjm-71	330	2	/	/	SYM
bptjm-71	330	3	fncel.2022.906270	fncel.2022.906270	NUM
bptjm-71	330	4	24	24	NUM
bptjm-71	330	5	.	.	PUNCT
bptjm-71	331	1	karabag	karabag	PROPN
bptjm-71	331	2	d	d	PROPN
bptjm-71	331	3	,	,	PUNCT
bptjm-71	331	4	scheiblich	scheiblich	ADJ
bptjm-71	331	5	h	h	NOUN
bptjm-71	331	6	,	,	PUNCT
bptjm-71	331	7	griep	griep	PROPN
bptjm-71	331	8	a	a	X
bptjm-71	331	9	,	,	PUNCT
bptjm-71	331	10	et	et	PROPN
bptjm-71	331	11	al	al	PROPN
bptjm-71	331	12	.	.	PROPN
bptjm-71	332	1	characterizing	characterize	VERB
bptjm-71	332	2	microglial	microglial	ADJ
bptjm-71	332	3	senescence	senescence	NOUN
bptjm-71	332	4	:	:	PUNCT
bptjm-71	332	5	tau	tau	PROPN
bptjm-71	332	6	as	as	ADP
bptjm-71	332	7	a	a	DET
bptjm-71	332	8	key	key	ADJ
bptjm-71	332	9	player	player	NOUN
bptjm-71	332	10	.	.	PUNCT
bptjm-71	333	1	j	j	PROPN
bptjm-71	333	2	neurochem	neurochem	PROPN
bptjm-71	333	3	.	.	PUNCT
bptjm-71	334	1	2023	2023	NUM
bptjm-71	334	2	;	;	PUNCT
bptjm-71	334	3	166(3	166(3	NUM
bptjm-71	334	4	):	):	PUNCT
bptjm-71	334	5	517	517	NUM
bptjm-71	334	6	-	-	SYM
bptjm-71	334	7	533	533	NUM
bptjm-71	334	8	.	.	PUNCT
bptjm-71	335	1	doi:10.1111	doi:10.1111	PROPN
bptjm-71	335	2	/	/	SYM
bptjm-71	335	3	jnc.15866	jnc.15866	PROPN
bptjm-71	335	4	25	25	NUM
bptjm-71	335	5	.	.	PUNCT
bptjm-71	335	6	dehkordi	dehkordi	PROPN
bptjm-71	335	7	sk	sk	PROPN
bptjm-71	335	8	,	,	PUNCT
bptjm-71	335	9	walker	walker	PROPN
bptjm-71	335	10	j	j	PROPN
bptjm-71	335	11	,	,	PUNCT
bptjm-71	335	12	sah	sah	PROPN
bptjm-71	335	13	e	e	PROPN
bptjm-71	335	14	,	,	PUNCT
bptjm-71	335	15	et	et	PROPN
bptjm-71	335	16	al	al	PROPN
bptjm-71	335	17	.	.	PUNCT
bptjm-71	336	1	profiling	profile	VERB
bptjm-71	336	2	senescent	senescent	ADJ
bptjm-71	336	3	cells	cell	NOUN
bptjm-71	336	4	in	in	ADP
bptjm-71	336	5	human	human	ADJ
bptjm-71	336	6	brains	brain	NOUN
bptjm-71	336	7	reveals	reveal	VERB
bptjm-71	336	8	neurons	neuron	NOUN
bptjm-71	336	9	with	with	ADP
bptjm-71	336	10	cdkn2d	cdkn2d	PROPN
bptjm-71	336	11	/	/	SYM
bptjm-71	336	12	p19	p19	NOUN
bptjm-71	336	13	and	and	CCONJ
bptjm-71	336	14	tau	tau	PROPN
bptjm-71	336	15	neuropathology.nat	neuropathology.nat	X
bptjm-71	336	16	aging	aging	NOUN
bptjm-71	336	17	.	.	PUNCT
bptjm-71	336	18	2021	2021	NUM
bptjm-71	336	19	;	;	PUNCT
bptjm-71	336	20	1(12	1(12	NUM
bptjm-71	336	21	):	):	PUNCT
bptjm-71	336	22	1107	1107	NUM
bptjm-71	336	23	-	-	SYM
bptjm-71	336	24	1116	1116	NUM
bptjm-71	336	25	.	.	PUNCT
bptjm-71	337	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	337	2	/	/	SYM
bptjm-71	337	3	s43587	s43587	PROPN
bptjm-71	337	4	-	-	PUNCT
bptjm-71	337	5	021	021	NUM
bptjm-71	337	6	-	-	PUNCT
bptjm-71	337	7	00142	00142	NUM
bptjm-71	337	8	-	-	SYM
bptjm-71	337	9	3	3	NUM
bptjm-71	337	10	26	26	NUM
bptjm-71	337	11	.	.	PUNCT
bptjm-71	337	12	ouhl	ouhl	PROPN
bptjm-71	337	13	,	,	PUNCT
bptjm-71	337	14	hoffmann	hoffmann	PROPN
bptjm-71	337	15	r	r	PROPN
bptjm-71	337	16	,	,	PUNCT
bptjm-71	337	17	gonzález	gonzález	NOUN
bptjm-71	337	18	-	-	PUNCT
bptjm-71	337	19	lópez	lópez	PROPN
bptjm-71	337	20	c	c	NOUN
bptjm-71	337	21	,	,	PUNCT
bptjm-71	337	22	doherty	doherty	PROPN
bptjm-71	337	23	gj	gj	PROPN
bptjm-71	337	24	,	,	PUNCT
bptjm-71	337	25	korkola	korkola	PROPN
bptjm-71	337	26	je	je	PROPN
bptjm-71	337	27	,	,	PUNCT
bptjm-71	337	28	muñoz	muñoz	PROPN
bptjm-71	337	29	-	-	PUNCT
bptjm-71	337	30	espín	espín	ADJ
bptjm-71	337	31	d.	d.	PROPN
bptjm-71	337	32	cellular	cellular	ADJ
bptjm-71	337	33	senescence	senescence	NOUN
bptjm-71	337	34	in	in	ADP
bptjm-71	337	35	cancer	cancer	NOUN
bptjm-71	337	36	:	:	PUNCT
bptjm-71	337	37	frommechanisms	frommechanism	VERB
bptjm-71	337	38	to	to	ADP
bptjm-71	337	39	detection.mol	detection.mol	PROPN
bptjm-71	337	40	oncol	oncol	ADJ
bptjm-71	337	41	.	.	PUNCT
bptjm-71	338	1	2021	2021	NUM
bptjm-71	338	2	oct	oct	NOUN
bptjm-71	338	3	;	;	PUNCT
bptjm-71	338	4	15(10	15(10	NUM
bptjm-71	338	5	):	):	PUNCT
bptjm-71	338	6	berkeley	berkeley	PROPN
bptjm-71	338	7	pharma	pharma	PROPN
bptjm-71	338	8	tech	tech	NOUN
bptjm-71	338	9	journal	journal	NOUN
bptjm-71	338	10	of	of	ADP
bptjm-71	338	11	medicine	medicine	NOUN
bptjm-71	338	12	|71	|71	NOUN
bptjm-71	338	13	2634	2634	NUM
bptjm-71	338	14	-	-	SYM
bptjm-71	338	15	2671	2671	NUM
bptjm-71	338	16	.	.	PUNCT
bptjm-71	339	1	doi	doi	NOUN
bptjm-71	339	2	:	:	PUNCT
bptjm-71	339	3	10.1002/1878	10.1002/1878	NUM
bptjm-71	339	4	-	-	PUNCT
bptjm-71	339	5	0261.12807	0261.12807	NOUN
bptjm-71	339	6	.	.	PUNCT
bptjm-71	340	1	epub	epub	PROPN
bptjm-71	340	2	2020	2020	NUM
bptjm-71	340	3	oct	oct	PROPN
bptjm-71	340	4	22	22	NUM
bptjm-71	340	5	.	.	PUNCT
bptjm-71	341	1	pmid	pmid	NOUN
bptjm-71	341	2	:	:	PUNCT
bptjm-71	341	3	32981205	32981205	NUM
bptjm-71	341	4	;	;	PUNCT
bptjm-71	341	5	pmcid	pmcid	ADJ
bptjm-71	341	6	:	:	PUNCT
bptjm-71	341	7	pmc8486596	pmc8486596	NOUN
bptjm-71	341	8	.	.	PUNCT
bptjm-71	342	1	27	27	NUM
bptjm-71	342	2	.	.	PUNCT
bptjm-71	343	1	gaikwad	gaikwad	PROPN
bptjm-71	343	2	s	s	PROPN
bptjm-71	343	3	,	,	PUNCT
bptjm-71	343	4	puangmalai	puangmalai	PROPN
bptjm-71	343	5	n	n	CCONJ
bptjm-71	343	6	,	,	PUNCT
bptjm-71	343	7	bittar	bittar	PROPN
bptjm-71	343	8	a	a	PROPN
bptjm-71	343	9	,	,	PUNCT
bptjm-71	343	10	et	et	PROPN
bptjm-71	343	11	al	al	PROPN
bptjm-71	343	12	.	.	PUNCT
bptjm-71	344	1	tau	tau	PROPN
bptjm-71	344	2	oligomer	oligomer	PROPN
bptjm-71	344	3	induced	induce	VERB
bptjm-71	344	4	hmgb1	hmgb1	PROPN
bptjm-71	344	5	release	release	NOUN
bptjm-71	344	6	contributes	contribute	VERB
bptjm-71	344	7	to	to	ADP
bptjm-71	344	8	cellular	cellular	ADJ
bptjm-71	344	9	senescence	senescence	NOUN
bptjm-71	344	10	and	and	CCONJ
bptjm-71	344	11	neuropathology	neuropathology	NOUN
bptjm-71	344	12	linked	link	VERB
bptjm-71	344	13	to	to	ADP
bptjm-71	344	14	alzheimer	alzheimer	PROPN
bptjm-71	344	15	's	's	PART
bptjm-71	344	16	disease	disease	NOUN
bptjm-71	344	17	and	and	CCONJ
bptjm-71	344	18	frontotemporal	frontotemporal	ADJ
bptjm-71	344	19	dementia	dementia	NOUN
bptjm-71	344	20	.	.	PUNCT
bptjm-71	345	1	cell	cell	PROPN
bptjm-71	345	2	rep	rep	PROPN
bptjm-71	345	3	.	.	PROPN
bptjm-71	345	4	2021	2021	NUM
bptjm-71	345	5	;	;	PUNCT
bptjm-71	345	6	36(3	36(3	NUM
bptjm-71	345	7	):	):	PUNCT
bptjm-71	345	8	109419	109419	NUM
bptjm-71	345	9	.	.	PUNCT
bptjm-71	346	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	346	2	/	/	SYM
bptjm-71	346	3	j.celrep.2021.109419	j.celrep.2021.109419	PROPN
bptjm-71	346	4	28	28	NUM
bptjm-71	346	5	.	.	PUNCT
bptjm-71	347	1	shimi	shimi	PROPN
bptjm-71	347	2	t	t	PROPN
bptjm-71	347	3	,	,	PUNCT
bptjm-71	347	4	butin	butin	PROPN
bptjm-71	347	5	-	-	PUNCT
bptjm-71	347	6	israeli	israeli	PROPN
bptjm-71	347	7	v	v	PROPN
bptjm-71	347	8	,	,	PUNCT
bptjm-71	347	9	adam	adam	PROPN
bptjm-71	347	10	sa	sa	PROPN
bptjm-71	347	11	,	,	PUNCT
bptjm-71	347	12	et	et	PROPN
bptjm-71	347	13	al	al	PROPN
bptjm-71	347	14	.	.	PUNCT
bptjm-71	348	1	the	the	DET
bptjm-71	348	2	role	role	NOUN
bptjm-71	348	3	of	of	ADP
bptjm-71	348	4	nuclear	nuclear	ADJ
bptjm-71	348	5	lamin	lamin	NOUN
bptjm-71	348	6	b1	b1	NOUN
bptjm-71	348	7	in	in	ADP
bptjm-71	348	8	cell	cell	NOUN
bptjm-71	348	9	proliferation	proliferation	NOUN
bptjm-71	348	10	and	and	CCONJ
bptjm-71	348	11	senescence.genes	senescence.genes	PROPN
bptjm-71	348	12	dev	dev	PROPN
bptjm-71	348	13	.	.	PROPN
bptjm-71	348	14	2011	2011	NUM
bptjm-71	348	15	;	;	PUNCT
bptjm-71	348	16	25(24	25(24	NUM
bptjm-71	348	17	):	):	PUNCT
bptjm-71	348	18	2579	2579	NUM
bptjm-71	348	19	-	-	SYM
bptjm-71	348	20	2593	2593	NUM
bptjm-71	348	21	.	.	PUNCT
bptjm-71	349	1	doi:10.1101	doi:10.1101	NOUN
bptjm-71	349	2	/	/	SYM
bptjm-71	349	3	gad.179515.111	gad.179515.111	PROPN
bptjm-71	349	4	29	29	NUM
bptjm-71	349	5	.	.	PUNCT
bptjm-71	350	1	wang	wang	PROPN
bptjm-71	350	2	j	j	PROPN
bptjm-71	350	3	,	,	PUNCT
bptjm-71	350	4	ding	ding	NOUN
bptjm-71	350	5	n	n	CCONJ
bptjm-71	350	6	,	,	PUNCT
bptjm-71	350	7	li	li	PROPN
bptjm-71	350	8	y	y	PROPN
bptjm-71	350	9	,	,	PUNCT
bptjm-71	350	10	et	et	PROPN
bptjm-71	350	11	al	al	PROPN
bptjm-71	350	12	.	.	PUNCT
bptjm-71	351	1	insulin	insulin	NOUN
bptjm-71	351	2	-	-	PUNCT
bptjm-71	351	3	like	like	ADJ
bptjm-71	351	4	growth	growth	NOUN
bptjm-71	351	5	factor	factor	NOUN
bptjm-71	351	6	binding	bind	VERB
bptjm-71	351	7	protein	protein	NOUN
bptjm-71	351	8	5	5	NUM
bptjm-71	351	9	(	(	PUNCT
bptjm-71	351	10	igfbp5	igfbp5	NOUN
bptjm-71	351	11	)	)	PUNCT
bptjm-71	351	12	functions	function	NOUN
bptjm-71	351	13	as	as	ADP
bptjm-71	351	14	a	a	DET
bptjm-71	351	15	tumor	tumor	NOUN
bptjm-71	351	16	suppressor	suppressor	NOUN
bptjm-71	351	17	in	in	ADP
bptjm-71	351	18	human	human	ADJ
bptjm-71	351	19	melanoma	melanoma	NOUN
bptjm-71	351	20	cells	cell	NOUN
bptjm-71	351	21	.	.	PUNCT
bptjm-71	352	1	oncotarget	oncotarget	NOUN
bptjm-71	352	2	.	.	PUNCT
bptjm-71	353	1	2015	2015	NUM
bptjm-71	353	2	;	;	PUNCT
bptjm-71	353	3	6(24	6(24	NUM
bptjm-71	353	4	):	):	PUNCT
bptjm-71	353	5	20636	20636	NUM
bptjm-71	353	6	-	-	SYM
bptjm-71	353	7	20649	20649	NUM
bptjm-71	353	8	.	.	PUNCT
bptjm-71	354	1	doi:10.18632	doi:10.18632	PROPN
bptjm-71	354	2	/	/	SYM
bptjm-71	354	3	oncotarget.4114	oncotarget.4114	ADJ
bptjm-71	354	4	30	30	NUM
bptjm-71	354	5	.	.	PUNCT
bptjm-71	355	1	lopresti	lopresti	PROPN
bptjm-71	355	2	p.	p.	NOUN
bptjm-71	355	3	inducible	inducible	ADJ
bptjm-71	355	4	expression	expression	NOUN
bptjm-71	355	5	of	of	ADP
bptjm-71	355	6	a	a	DET
bptjm-71	355	7	truncated	truncated	ADJ
bptjm-71	355	8	form	form	NOUN
bptjm-71	355	9	of	of	ADP
bptjm-71	355	10	tau	tau	PROPN
bptjm-71	355	11	in	in	ADP
bptjm-71	355	12	oligodendrocytes	oligodendrocyte	NOUN
bptjm-71	355	13	elicits	elicit	VERB
bptjm-71	355	14	gait	gait	ADJ
bptjm-71	355	15	abnormalities	abnormality	NOUN
bptjm-71	355	16	and	and	CCONJ
bptjm-71	355	17	a	a	DET
bptjm-71	355	18	decrease	decrease	NOUN
bptjm-71	355	19	in	in	ADP
bptjm-71	355	20	myelin	myelin	NOUN
bptjm-71	355	21	:	:	PUNCT
bptjm-71	355	22	implications	implication	NOUN
bptjm-71	355	23	for	for	ADP
bptjm-71	355	24	selective	selective	ADJ
bptjm-71	355	25	cns	cns	PROPN
bptjm-71	355	26	degenerative	degenerative	PROPN
bptjm-71	355	27	diseases.neurochem	diseases.neurochem	PROPN
bptjm-71	355	28	res	re	NOUN
bptjm-71	355	29	.	.	PUNCT
bptjm-71	355	30	2015	2015	NUM
bptjm-71	355	31	;	;	PUNCT
bptjm-71	355	32	40(11	40(11	NUM
bptjm-71	355	33	):	):	PUNCT
bptjm-71	355	34	2188	2188	NUM
bptjm-71	355	35	-	-	SYM
bptjm-71	355	36	2199	2199	NUM
bptjm-71	355	37	.	.	PUNCT
bptjm-71	356	1	doi:10.1007	doi:10.1007	VERB
bptjm-71	356	2	/	/	SYM
bptjm-71	356	3	s11064	s11064	NOUN
bptjm-71	356	4	-	-	PUNCT
bptjm-71	356	5	015	015	NUM
bptjm-71	356	6	-	-	PUNCT
bptjm-71	356	7	1707	1707	NUM
bptjm-71	356	8	-	-	PUNCT
bptjm-71	356	9	x	x	SYM
bptjm-71	356	10	31	31	NUM
bptjm-71	356	11	.	.	PUNCT
bptjm-71	357	1	michalicova	michalicova	VERB
bptjm-71	357	2	a	a	DET
bptjm-71	357	3	,	,	PUNCT
bptjm-71	357	4	majerova	majerova	PROPN
bptjm-71	357	5	p	p	X
bptjm-71	357	6	,	,	PUNCT
bptjm-71	357	7	kovac	kovac	PROPN
bptjm-71	357	8	a.	a.	PROPN
bptjm-71	357	9	tau	tau	PROPN
bptjm-71	357	10	protein	protein	NOUN
bptjm-71	357	11	and	and	CCONJ
bptjm-71	357	12	its	its	PRON
bptjm-71	357	13	role	role	NOUN
bptjm-71	357	14	in	in	ADP
bptjm-71	357	15	blood	blood	NOUN
bptjm-71	357	16	-	-	PUNCT
bptjm-71	357	17	brain	brain	NOUN
bptjm-71	357	18	barrier	barrier	NOUN
bptjm-71	357	19	dysfunction	dysfunction	NOUN
bptjm-71	357	20	.	.	PUNCT
bptjm-71	358	1	frontmol	frontmol	PROPN
bptjm-71	358	2	neurosci	neurosci	PROPN
bptjm-71	358	3	.	.	PUNCT
bptjm-71	359	1	2020;13:570045	2020;13:570045	NUM
bptjm-71	359	2	.	.	NUM
bptjm-71	359	3	published	publish	VERB
bptjm-71	359	4	2020	2020	NUM
bptjm-71	359	5	sep	sep	PROPN
bptjm-71	359	6	30	30	NUM
bptjm-71	359	7	.	.	PUNCT
bptjm-71	360	1	doi:10.3389	doi:10.3389	PROPN
bptjm-71	360	2	/	/	SYM
bptjm-71	360	3	fnmol.2020.570045	fnmol.2020.570045	PROPN
bptjm-71	360	4	32	32	NUM
bptjm-71	360	5	.	.	PUNCT
bptjm-71	361	1	bakota	bakota	PROPN
bptjm-71	361	2	l	l	PROPN
bptjm-71	361	3	,	,	PUNCT
bptjm-71	361	4	brandt	brandt	PROPN
bptjm-71	361	5	r.	r.	PROPN
bptjm-71	361	6	tau	tau	PROPN
bptjm-71	361	7	biology	biology	NOUN
bptjm-71	361	8	and	and	CCONJ
bptjm-71	361	9	tau	tau	NOUN
bptjm-71	361	10	-	-	PUNCT
bptjm-71	361	11	directed	direct	VERB
bptjm-71	361	12	therapies	therapy	NOUN
bptjm-71	361	13	for	for	ADP
bptjm-71	361	14	alzheimer	alzheimer	PROPN
bptjm-71	361	15	's	's	PART
bptjm-71	361	16	disease	disease	NOUN
bptjm-71	361	17	.	.	PUNCT
bptjm-71	362	1	drugs	drug	NOUN
bptjm-71	362	2	.	.	PUNCT
bptjm-71	363	1	2016	2016	NUM
bptjm-71	363	2	;	;	PUNCT
bptjm-71	364	1	76(3	76(3	NUM
bptjm-71	364	2	):	):	PUNCT
bptjm-71	364	3	301	301	NUM
bptjm-71	364	4	-	-	SYM
bptjm-71	364	5	313	313	NUM
bptjm-71	364	6	.	.	PUNCT
bptjm-71	365	1	doi:10.1007	doi:10.1007	VERB
bptjm-71	365	2	/	/	SYM
bptjm-71	365	3	s40265	s40265	NOUN
bptjm-71	365	4	-	-	PUNCT
bptjm-71	365	5	015	015	NUM
bptjm-71	365	6	-	-	PUNCT
bptjm-71	365	7	0529	0529	NUM
bptjm-71	365	8	-	-	SYM
bptjm-71	365	9	0	0	NUM
bptjm-71	365	10	33	33	NUM
bptjm-71	365	11	.	.	PUNCT
bptjm-71	366	1	olson	olson	PROPN
bptjm-71	366	2	a	a	PROPN
bptjm-71	366	3	,	,	PUNCT
bptjm-71	366	4	hussong	hussong	PROPN
bptjm-71	366	5	sa	sa	PROPN
bptjm-71	366	6	,	,	PUNCT
bptjm-71	366	7	kayed	kaye	VERB
bptjm-71	366	8	r	r	NOUN
bptjm-71	366	9	,	,	PUNCT
bptjm-71	366	10	galvan	galvan	NOUN
bptjm-71	366	11	v	v	NOUN
bptjm-71	366	12	.	.	PUNCT
bptjm-71	367	1	tau	tau	PROPN
bptjm-71	367	2	-	-	PUNCT
bptjm-71	367	3	inducedastrocyte	inducedastrocyte	PROPN
bptjm-71	367	4	senescence	senescence	NOUN
bptjm-71	367	5	:	:	PUNCT
bptjm-71	367	6	anovelmechanism	anovelmechanism	PROPN
bptjm-71	367	7	forneuronaldysfunction	forneuronaldysfunction	NOUN
bptjm-71	367	8	in	in	ADP
bptjm-71	367	9	alzheimer	alzheimer	PROPN
bptjm-71	367	10	’s	’s	PART
bptjm-71	367	11	disease	disease	NOUN
bptjm-71	367	12	.	.	PUNCT
bptjm-71	368	1	innov	innov	PROPN
bptjm-71	368	2	aging	aging	NOUN
bptjm-71	368	3	.	.	PUNCT
bptjm-71	368	4	2019	2019	NUM
bptjm-71	369	1	;	;	PUNCT
bptjm-71	369	2	3(suppl	3(suppl	PROPN
bptjm-71	369	3	1	1	NUM
bptjm-71	369	4	):	):	PUNCT
bptjm-71	369	5	s91	s91	NOUN
bptjm-71	369	6	-	-	PUNCT
bptjm-71	369	7	s92	s92	NOUN
bptjm-71	369	8	.	.	PUNCT
bptjm-71	370	1	published	publish	VERB
bptjm-71	370	2	2019	2019	NUM
bptjm-71	370	3	nov	nov	PROPN
bptjm-71	370	4	8	8	NUM
bptjm-71	370	5	.	.	PUNCT
bptjm-71	370	6	doi:10.1093	doi:10.1093	NOUN
bptjm-71	370	7	/	/	SYM
bptjm-71	370	8	geroni	geroni	PROPN
bptjm-71	370	9	/	/	SYM
bptjm-71	370	10	igz038.348	igz038.348	PROPN
bptjm-71	370	11	34	34	NUM
bptjm-71	370	12	.	.	PUNCT
bptjm-71	371	1	farmer	farmer	PROPN
bptjm-71	371	2	,	,	PUNCT
bptjm-71	371	3	k.m	k.m	PROPN
bptjm-71	371	4	.	.	PROPN
bptjm-71	371	5	,	,	PUNCT
bptjm-71	371	6	ghag	ghag	PROPN
bptjm-71	371	7	,	,	PUNCT
bptjm-71	371	8	g.	g.	PROPN
bptjm-71	371	9	,	,	PUNCT
bptjm-71	371	10	puangmalai	puangmalai	NOUN
bptjm-71	371	11	,	,	PUNCT
bptjm-71	371	12	n.	n.	PROPN
bptjm-71	371	13	et	et	PROPN
bptjm-71	371	14	al	al	PROPN
bptjm-71	371	15	.	.	PROPN
bptjm-71	371	16	p53	p53	NOUN
bptjm-71	371	17	aggregation	aggregation	NOUN
bptjm-71	371	18	,	,	PUNCT
bptjm-71	371	19	interactions	interaction	NOUN
bptjm-71	371	20	with	with	ADP
bptjm-71	371	21	tau	tau	PROPN
bptjm-71	371	22	,	,	PUNCT
bptjm-71	371	23	and	and	CCONJ
bptjm-71	371	24	impaired	impaired	ADJ
bptjm-71	371	25	dna	dna	NOUN
bptjm-71	371	26	damage	damage	NOUN
bptjm-71	371	27	response	response	NOUN
bptjm-71	371	28	in	in	ADP
bptjm-71	371	29	alzheimer	alzheimer	PROPN
bptjm-71	371	30	’s	’s	PART
bptjm-71	371	31	disease	disease	NOUN
bptjm-71	371	32	.	.	PUNCT
bptjm-71	372	1	acta	acta	PROPN
bptjm-71	372	2	neuropathol	neuropathol	PROPN
bptjm-71	372	3	commun	commun	PROPN
bptjm-71	372	4	8	8	NUM
bptjm-71	372	5	,	,	PUNCT
bptjm-71	372	6	132	132	NUM
bptjm-71	372	7	(	(	PUNCT
bptjm-71	372	8	2020	2020	NUM
bptjm-71	372	9	)	)	PUNCT
bptjm-71	372	10	.	.	PUNCT
bptjm-71	373	1	doi:10.1186	doi:10.1186	PROPN
bptjm-71	373	2	/	/	SYM
bptjm-71	373	3	s40478	s40478	PROPN
bptjm-71	373	4	-	-	PUNCT
bptjm-71	373	5	020	020	NUM
bptjm-71	373	6	-	-	PUNCT
bptjm-71	373	7	01012	01012	NUM
bptjm-71	373	8	-	-	SYM
bptjm-71	373	9	6	6	NUM
bptjm-71	373	10	35	35	NUM
bptjm-71	373	11	.	.	PUNCT
bptjm-71	374	1	limbad	limbad	PROPN
bptjm-71	374	2	c	c	PROPN
bptjm-71	374	3	,	,	PUNCT
bptjm-71	374	4	oron	oron	PROPN
bptjm-71	374	5	tr	tr	VERB
bptjm-71	374	6	,	,	PUNCT
bptjm-71	374	7	alimirah	alimirah	PROPN
bptjm-71	374	8	f	f	NUM
bptjm-71	374	9	,	,	PUNCT
bptjm-71	374	10	et	et	PROPN
bptjm-71	374	11	al	al	PROPN
bptjm-71	374	12	.	.	PROPN
bptjm-71	374	13	astrocyte	astrocyte	PROPN
bptjm-71	374	14	senescence	senescence	NOUN
bptjm-71	374	15	promotes	promote	VERB
bptjm-71	374	16	glutamate	glutamate	ADJ
bptjm-71	374	17	toxicity	toxicity	NOUN
bptjm-71	374	18	in	in	ADP
bptjm-71	374	19	cortical	cortical	ADJ
bptjm-71	374	20	neurons	neuron	NOUN
bptjm-71	374	21	.	.	PUNCT
bptjm-71	375	1	plos	plos	PROPN
bptjm-71	375	2	one	one	NUM
bptjm-71	375	3	.	.	PUNCT
bptjm-71	376	1	2020	2020	NUM
bptjm-71	376	2	;	;	PUNCT
bptjm-71	376	3	15(1	15(1	NUM
bptjm-71	376	4	):	):	PUNCT
bptjm-71	376	5	e0227887	e0227887	PROPN
bptjm-71	376	6	.	.	PUNCT
bptjm-71	377	1	published	publish	VERB
bptjm-71	377	2	2020	2020	NUM
bptjm-71	377	3	jan	jan	PROPN
bptjm-71	377	4	16	16	NUM
bptjm-71	377	5	.	.	PUNCT
bptjm-71	377	6	doi:10.1371	doi:10.1371	PROPN
bptjm-71	377	7	/	/	SYM
bptjm-71	378	1	journal.pone.0227887	journal.pone.0227887	PROPN
bptjm-71	378	2	36	36	NUM
bptjm-71	378	3	.	.	PUNCT
bptjm-71	379	1	streit	streit	PROPN
bptjm-71	379	2	wj	wj	PROPN
bptjm-71	379	3	,	,	PUNCT
bptjm-71	379	4	braak	braak	PROPN
bptjm-71	379	5	h	h	PROPN
bptjm-71	379	6	,	,	PUNCT
bptjm-71	379	7	xue	xue	PROPN
bptjm-71	379	8	qs	qs	PROPN
bptjm-71	379	9	,	,	PUNCT
bptjm-71	379	10	bechmann	bechmann	PROPN
bptjm-71	379	11	i.	i.	PROPN
bptjm-71	379	12	dystrophic	dystrophic	PROPN
bptjm-71	379	13	(	(	PUNCT
bptjm-71	379	14	senescent	senescent	NOUN
bptjm-71	379	15	)	)	PUNCT
bptjm-71	379	16	rather	rather	ADV
bptjm-71	379	17	than	than	ADP
bptjm-71	379	18	activated	activate	VERB
bptjm-71	379	19	microglial	microglial	ADJ
bptjm-71	379	20	cells	cell	NOUN
bptjm-71	379	21	are	be	AUX
bptjm-71	379	22	associated	associate	VERB
bptjm-71	379	23	with	with	ADP
bptjm-71	379	24	tau	tau	PROPN
bptjm-71	379	25	pathology	pathology	NOUN
bptjm-71	379	26	and	and	CCONJ
bptjm-71	379	27	likely	likely	ADV
bptjm-71	379	28	precede	precede	VERB
bptjm-71	379	29	neurodegeneration	neurodegeneration	NOUN
bptjm-71	379	30	in	in	ADP
bptjm-71	379	31	alzheimer	alzheimer	PROPN
bptjm-71	379	32	's	's	PART
bptjm-71	379	33	disease	disease	NOUN
bptjm-71	379	34	.	.	PUNCT
bptjm-71	380	1	acta	acta	PROPN
bptjm-71	380	2	neuropathol	neuropathol	PROPN
bptjm-71	380	3	.	.	PUNCT
bptjm-71	381	1	2009	2009	NUM
bptjm-71	381	2	;	;	PUNCT
bptjm-71	381	3	118(4	118(4	NUM
bptjm-71	381	4	):	):	PUNCT
bptjm-71	381	5	475	475	NUM
bptjm-71	381	6	-	-	SYM
bptjm-71	381	7	485	485	NUM
bptjm-71	381	8	.	.	PUNCT
bptjm-71	381	9	doi:10.1007	doi:10.1007	VERB
bptjm-71	381	10	/	/	SYM
bptjm-71	381	11	s00401	s00401	NOUN
bptjm-71	381	12	-	-	PUNCT
bptjm-71	381	13	009	009	NUM
bptjm-71	381	14	-	-	PUNCT
bptjm-71	381	15	0556	0556	NUM
bptjm-71	381	16	-	-	SYM
bptjm-71	381	17	6	6	NUM
bptjm-71	381	18	37	37	NUM
bptjm-71	381	19	.	.	PUNCT
bptjm-71	382	1	viney	viney	PROPN
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bptjm-71	382	3	,	,	PUNCT
bptjm-71	382	4	sarkany	sarkany	PROPN
bptjm-71	382	5	b	b	PROPN
bptjm-71	382	6	,	,	PUNCT
bptjm-71	382	7	ozdemir	ozdemir	VERB
bptjm-71	382	8	a	a	DET
bptjm-71	382	9	t	t	PROPN
bptjm-71	382	10	,	,	PUNCT
bptjm-71	382	11	et	et	PROPN
bptjm-71	382	12	al	al	PROPN
bptjm-71	382	13	.	.	PROPN
bptjm-71	382	14	spread	spread	PROPN
bptjm-71	382	15	of	of	ADP
bptjm-71	382	16	pathological	pathological	ADJ
bptjm-71	382	17	human	human	PROPN
bptjm-71	382	18	tau	tau	PROPN
bptjm-71	382	19	from	from	ADP
bptjm-71	382	20	neurons	neuron	NOUN
bptjm-71	382	21	to	to	ADP
bptjm-71	382	22	oligodendrocytes	oligodendrocyte	NOUN
bptjm-71	382	23	and	and	CCONJ
bptjm-71	382	24	loss	loss	NOUN
bptjm-71	382	25	of	of	ADP
bptjm-71	382	26	high	high	ADJ
bptjm-71	382	27	-	-	PUNCT
bptjm-71	382	28	firing	firing	NOUN
bptjm-71	382	29	pyramidal	pyramidal	ADJ
bptjm-71	382	30	neurons	neuron	NOUN
bptjm-71	382	31	in	in	ADP
bptjm-71	382	32	aging	age	VERB
bptjm-71	382	33	mice	mouse	NOUN
bptjm-71	382	34	.	.	PUNCT
bptjm-71	383	1	cell	cell	NOUN
bptjm-71	383	2	rep	rep	PROPN
bptjm-71	383	3	.	.	PROPN
bptjm-71	383	4	2022	2022	NUM
bptjm-71	383	5	;	;	PUNCT
bptjm-71	383	6	41(7	41(7	NUM
bptjm-71	383	7	):	):	PUNCT
bptjm-71	383	8	111646	111646	NUM
bptjm-71	383	9	.	.	PUNCT
bptjm-71	384	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	384	2	/	/	SYM
bptjm-71	384	3	j.celrep.2022.111646	j.celrep.2022.111646	PROPN
bptjm-71	384	4	38	38	NUM
bptjm-71	384	5	.	.	PUNCT
bptjm-71	385	1	demaegd	demaegd	PROPN
bptjm-71	385	2	k	k	PROPN
bptjm-71	385	3	,	,	PUNCT
bptjm-71	385	4	schymkowitz	schymkowitz	PROPN
bptjm-71	385	5	j	j	PROPN
bptjm-71	385	6	,	,	PUNCT
bptjm-71	385	7	rousseau	rousseau	PROPN
bptjm-71	385	8	f.	f.	PROPN
bptjm-71	385	9	transcellular	transcellular	PROPN
bptjm-71	385	10	spreading	spread	VERB
bptjm-71	385	11	of	of	ADP
bptjm-71	385	12	tau	tau	PROPN
bptjm-71	385	13	in	in	ADP
bptjm-71	385	14	tauopathies	tauopathie	NOUN
bptjm-71	385	15	.	.	PUNCT
bptjm-71	386	1	chembiochem	chembiochem	PROPN
bptjm-71	386	2	.	.	PUNCT
bptjm-71	387	1	2018	2018	NUM
bptjm-71	387	2	;	;	PUNCT
bptjm-71	388	1	19(23	19(23	NOUN
bptjm-71	388	2	):	):	PUNCT
bptjm-71	388	3	2424	2424	NUM
bptjm-71	388	4	-	-	SYM
bptjm-71	388	5	2432	2432	NUM
bptjm-71	388	6	.	.	PUNCT
bptjm-71	389	1	doi:10.1002	doi:10.1002	NOUN
bptjm-71	389	2	/	/	SYM
bptjm-71	389	3	cbic.201800288	cbic.201800288	PROPN
bptjm-71	389	4	39	39	NUM
bptjm-71	389	5	.	.	PUNCT
bptjm-71	390	1	narasimhan	narasimhan	PROPN
bptjm-71	390	2	s	s	PROPN
bptjm-71	390	3	,	,	PUNCT
bptjm-71	390	4	guo	guo	PROPN
bptjm-71	390	5	jl	jl	PROPN
bptjm-71	390	6	,	,	PUNCT
bptjm-71	390	7	changolkar	changolkar	PROPN
bptjm-71	390	8	l	l	NOUN
bptjm-71	390	9	,	,	PUNCT
bptjm-71	390	10	et	et	PROPN
bptjm-71	390	11	al	al	PROPN
bptjm-71	390	12	.	.	PROPN
bptjm-71	391	1	pathological	pathological	PROPN
bptjm-71	391	2	tau	tau	PROPN
bptjm-71	391	3	strains	strain	VERB
bptjm-71	391	4	fromhuman	fromhuman	ADJ
bptjm-71	391	5	brains	brain	NOUN
bptjm-71	391	6	recapitulate	recapitulate	VERB
bptjm-71	391	7	the	the	DET
bptjm-71	391	8	diversity	diversity	NOUN
bptjm-71	391	9	of	of	ADP
bptjm-71	391	10	berkeley	berkeley	PROPN
bptjm-71	391	11	pharma	pharma	PROPN
bptjm-71	391	12	tech	tech	NOUN
bptjm-71	391	13	journal	journal	NOUN
bptjm-71	391	14	of	of	ADP
bptjm-71	391	15	medicine	medicine	NOUN
bptjm-71	391	16	|72	|72	PROPN
bptjm-71	391	17	tauopathies	tauopathie	NOUN
bptjm-71	391	18	in	in	ADP
bptjm-71	391	19	nontransgenic	nontransgenic	ADJ
bptjm-71	391	20	mouse	mouse	NOUN
bptjm-71	391	21	brain	brain	NOUN
bptjm-71	391	22	.	.	PUNCT
bptjm-71	392	1	j	j	PROPN
bptjm-71	392	2	neurosci	neurosci	PROPN
bptjm-71	392	3	.	.	PUNCT
bptjm-71	393	1	2017	2017	NUM
bptjm-71	393	2	;	;	PUNCT
bptjm-71	393	3	37(47	37(47	NUM
bptjm-71	393	4	):	):	PUNCT
bptjm-71	393	5	11406	11406	NUM
bptjm-71	393	6	-	-	SYM
bptjm-71	393	7	11423	11423	NUM
bptjm-71	393	8	.	.	PUNCT
bptjm-71	394	1	doi:10.1523	doi:10.1523	NOUN
bptjm-71	394	2	/	/	SYM
bptjm-71	394	3	jneurosci.1230	jneurosci.1230	VERB
bptjm-71	394	4	-	-	PUNCT
bptjm-71	394	5	17.2017	17.2017	NUM
bptjm-71	394	6	40	40	NUM
bptjm-71	394	7	.	.	PUNCT
bptjm-71	395	1	luo	luo	PROPN
bptjm-71	395	2	jxx	jxx	PROPN
bptjm-71	395	3	,	,	PUNCT
bptjm-71	395	4	cui	cui	PROPN
bptjm-71	395	5	ql	ql	PROPN
bptjm-71	395	6	,	,	PUNCT
bptjm-71	395	7	y	y	PROPN
bptjm-71	395	8	aqubi	aqubi	PROPN
bptjm-71	395	9	m	m	PROPN
bptjm-71	395	10	,	,	PUNCT
bptjm-71	395	11	et	et	PROPN
bptjm-71	395	12	al	al	PROPN
bptjm-71	395	13	.	.	PUNCT
bptjm-71	395	14	human	human	ADJ
bptjm-71	395	15	oligodendrocyte	oligodendrocyte	ADJ
bptjm-71	395	16	myelination	myelination	NOUN
bptjm-71	395	17	potential	potential	NOUN
bptjm-71	395	18	;	;	PUNCT
bptjm-71	395	19	relation	relation	NOUN
bptjm-71	395	20	to	to	ADP
bptjm-71	395	21	age	age	NOUN
bptjm-71	395	22	and	and	CCONJ
bptjm-71	395	23	differentiation	differentiation	NOUN
bptjm-71	395	24	.	.	PUNCT
bptjm-71	396	1	ann	ann	PROPN
bptjm-71	396	2	neurol	neurol	PROPN
bptjm-71	396	3	.	.	PUNCT
bptjm-71	397	1	2022	2022	NUM
bptjm-71	397	2	;	;	PUNCT
bptjm-71	397	3	91(2	91(2	NUM
bptjm-71	397	4	):	):	PUNCT
bptjm-71	397	5	178	178	NUM
bptjm-71	397	6	-	-	SYM
bptjm-71	397	7	191	191	NUM
bptjm-71	397	8	.	.	PUNCT
bptjm-71	398	1	doi:10.1002	doi:10.1002	NOUN
bptjm-71	398	2	/	/	SYM
bptjm-71	398	3	ana.26288	ana.26288	NUM
bptjm-71	398	4	41	41	NUM
bptjm-71	398	5	.	.	PUNCT
bptjm-71	399	1	wang	wang	PROPN
bptjm-71	399	2	dm	dm	PROPN
bptjm-71	399	3	,	,	PUNCT
bptjm-71	399	4	li	li	PROPN
bptjm-71	399	5	sq	sq	PROPN
bptjm-71	399	6	,	,	PUNCT
bptjm-71	399	7	wuwl	wuwl	ADV
bptjm-71	399	8	,	,	PUNCT
bptjm-71	399	9	zhu	zhu	PROPN
bptjm-71	399	10	xy	xy	PROPN
bptjm-71	399	11	,	,	PUNCT
bptjm-71	399	12	wang	wang	PROPN
bptjm-71	399	13	y	y	PROPN
bptjm-71	399	14	,	,	PUNCT
bptjm-71	399	15	yuan	yuan	NOUN
bptjm-71	399	16	hy	hy	PROPN
bptjm-71	399	17	.	.	PUNCT
bptjm-71	400	1	effects	effect	NOUN
bptjm-71	400	2	of	of	ADP
bptjm-71	400	3	long	long	ADJ
bptjm-71	400	4	-	-	PUNCT
bptjm-71	400	5	term	term	NOUN
bptjm-71	400	6	treatment	treatment	NOUN
bptjm-71	400	7	with	with	ADP
bptjm-71	400	8	quercetin	quercetin	NOUN
bptjm-71	400	9	on	on	ADP
bptjm-71	400	10	cognition	cognition	NOUN
bptjm-71	400	11	and	and	CCONJ
bptjm-71	400	12	mitochondrial	mitochondrial	ADJ
bptjm-71	400	13	function	function	NOUN
bptjm-71	400	14	in	in	ADP
bptjm-71	400	15	a	a	DET
bptjm-71	400	16	mouse	mouse	NOUN
bptjm-71	400	17	model	model	NOUN
bptjm-71	400	18	of	of	ADP
bptjm-71	400	19	alzheimer	alzheimer	PROPN
bptjm-71	400	20	's	's	PART
bptjm-71	400	21	disease	disease	NOUN
bptjm-71	400	22	.	.	PUNCT
bptjm-71	401	1	neurochem	neurochem	PROPN
bptjm-71	401	2	res	re	NOUN
bptjm-71	401	3	.	.	PUNCT
bptjm-71	401	4	2014	2014	NUM
bptjm-71	401	5	;	;	PUNCT
bptjm-71	401	6	39(8	39(8	NUM
bptjm-71	401	7	):	):	PUNCT
bptjm-71	401	8	1533	1533	NUM
bptjm-71	401	9	-	-	SYM
bptjm-71	401	10	1543	1543	NUM
bptjm-71	401	11	.	.	PUNCT
bptjm-71	402	1	doi:10.1007	doi:10.1007	VERB
bptjm-71	402	2	/	/	SYM
bptjm-71	402	3	s11064	s11064	NUM
bptjm-71	402	4	-	-	PUNCT
bptjm-71	402	5	014	014	NUM
bptjm-71	402	6	-	-	PUNCT
bptjm-71	402	7	1343	1343	NUM
bptjm-71	402	8	-	-	PUNCT
bptjm-71	402	9	x	x	SYM
bptjm-71	402	10	42	42	NUM
bptjm-71	402	11	.	.	PUNCT
bptjm-71	403	1	novais	novais	PROPN
bptjm-71	403	2	ej	ej	PROPN
bptjm-71	403	3	,	,	PUNCT
bptjm-71	403	4	tran	tran	PROPN
bptjm-71	403	5	v	v	PROPN
bptjm-71	403	6	a	a	PROPN
bptjm-71	403	7	,	,	PUNCT
bptjm-71	403	8	johnston	johnston	PROPN
bptjm-71	403	9	sn	sn	PROPN
bptjm-71	403	10	,	,	PUNCT
bptjm-71	403	11	et	et	PROPN
bptjm-71	403	12	al	al	PROPN
bptjm-71	403	13	.	.	PUNCT
bptjm-71	404	1	long	long	ADJ
bptjm-71	404	2	-	-	PUNCT
bptjm-71	404	3	term	term	NOUN
bptjm-71	404	4	treatment	treatment	NOUN
bptjm-71	404	5	with	with	ADP
bptjm-71	404	6	senolytic	senolytic	ADJ
bptjm-71	404	7	drugs	drug	NOUN
bptjm-71	404	8	dasatinib	dasatinib	NOUN
bptjm-71	404	9	and	and	CCONJ
bptjm-71	404	10	quercetin	quercetin	NOUN
bptjm-71	404	11	ameliorates	ameliorate	NOUN
bptjm-71	404	12	age	age	NOUN
bptjm-71	404	13	-	-	PUNCT
bptjm-71	404	14	dependent	dependent	ADJ
bptjm-71	404	15	intervertebral	intervertebral	ADJ
bptjm-71	404	16	disc	disc	NOUN
bptjm-71	404	17	degeneration	degeneration	NOUN
bptjm-71	404	18	in	in	ADP
bptjm-71	404	19	mice.nat	mice.nat	PROPN
bptjm-71	404	20	commun	commun	PROPN
bptjm-71	404	21	.	.	PUNCT
bptjm-71	404	22	2021	2021	NUM
bptjm-71	404	23	;	;	PUNCT
bptjm-71	404	24	12(1	12(1	NUM
bptjm-71	404	25	):	):	PUNCT
bptjm-71	404	26	5213	5213	NUM
bptjm-71	404	27	.	.	PUNCT
bptjm-71	405	1	published	publish	VERB
bptjm-71	405	2	2021	2021	NUM
bptjm-71	405	3	sep	sep	NOUN
bptjm-71	405	4	3	3	NUM
bptjm-71	405	5	.	.	PUNCT
bptjm-71	405	6	doi:10.1038	doi:10.1038	NOUN
bptjm-71	405	7	/	/	SYM
bptjm-71	405	8	s41467	s41467	NOUN
bptjm-71	405	9	-	-	PUNCT
bptjm-71	405	10	021	021	NUM
bptjm-71	405	11	-	-	PUNCT
bptjm-71	405	12	25453	25453	NUM
bptjm-71	405	13	-	-	SYM
bptjm-71	405	14	2	2	NUM
bptjm-71	405	15	43	43	NUM
bptjm-71	405	16	.	.	PUNCT
bptjm-71	406	1	ogrodnik	ogrodnik	PROPN
bptjm-71	406	2	m	m	PROPN
bptjm-71	406	3	,	,	PUNCT
bptjm-71	406	4	evans	evans	PROPN
bptjm-71	406	5	sa	sa	PROPN
bptjm-71	406	6	,	,	PUNCT
bptjm-71	406	7	fielder	fielder	NOUN
bptjm-71	406	8	e	e	NOUN
bptjm-71	406	9	,	,	PUNCT
bptjm-71	406	10	et	et	PROPN
bptjm-71	406	11	al	al	PROPN
bptjm-71	406	12	.	.	PUNCT
bptjm-71	406	13	whole	whole	ADJ
bptjm-71	406	14	-	-	PUNCT
bptjm-71	406	15	body	body	NOUN
bptjm-71	406	16	senescent	senescent	ADJ
bptjm-71	406	17	cell	cell	NOUN
bptjm-71	406	18	clearance	clearance	NOUN
bptjm-71	406	19	alleviates	alleviate	VERB
bptjm-71	406	20	age	age	NOUN
bptjm-71	406	21	-	-	PUNCT
bptjm-71	406	22	related	relate	VERB
bptjm-71	406	23	brain	brain	NOUN
bptjm-71	406	24	inflammation	inflammation	NOUN
bptjm-71	406	25	and	and	CCONJ
bptjm-71	406	26	cognitive	cognitive	ADJ
bptjm-71	406	27	impairment	impairment	NOUN
bptjm-71	406	28	in	in	ADP
bptjm-71	406	29	mice	mouse	NOUN
bptjm-71	406	30	.	.	PUNCT
bptjm-71	407	1	aging	age	VERB
bptjm-71	407	2	cell	cell	NOUN
bptjm-71	407	3	.	.	PUNCT
bptjm-71	408	1	2021	2021	NUM
bptjm-71	408	2	;	;	PUNCT
bptjm-71	408	3	20(2	20(2	NUM
bptjm-71	408	4	):	):	PUNCT
bptjm-71	408	5	e13296	e13296	NOUN
bptjm-71	408	6	.	.	PUNCT
bptjm-71	408	7	doi:10.1111	doi:10.1111	PROPN
bptjm-71	408	8	/	/	SYM
bptjm-71	408	9	acel.13296	acel.13296	PROPN
bptjm-71	408	10	44	44	NUM
bptjm-71	408	11	.	.	PUNCT
bptjm-71	409	1	orr	orr	PROPN
bptjm-71	409	2	m	m	PROPN
bptjm-71	409	3	,	,	PUNCT
bptjm-71	409	4	gonzales	gonzales	PROPN
bptjm-71	409	5	m	m	PROPN
bptjm-71	409	6	,	,	PUNCT
bptjm-71	409	7	garbarino	garbarino	PROPN
bptjm-71	409	8	v	v	NUM
bptjm-71	409	9	,	,	PUNCT
bptjm-71	409	10	et	et	PROPN
bptjm-71	409	11	al	al	PROPN
bptjm-71	409	12	.	.	PROPN
bptjm-71	409	13	senolytic	senolytic	PROPN
bptjm-71	409	14	therapy	therapy	NOUN
bptjm-71	409	15	to	to	PART
bptjm-71	409	16	modulate	modulate	VERB
bptjm-71	409	17	the	the	DET
bptjm-71	409	18	progression	progression	NOUN
bptjm-71	409	19	of	of	ADP
bptjm-71	409	20	alzheimer	alzheimer	PROPN
bptjm-71	409	21	's	's	PART
bptjm-71	409	22	disease	disease	NOUN
bptjm-71	409	23	(	(	PUNCT
bptjm-71	409	24	stomp	stomp	NOUN
bptjm-71	409	25	-	-	PUNCT
bptjm-71	409	26	ad	ad	NOUN
bptjm-71	409	27	)	)	PUNCT
bptjm-71	409	28	outcomes	outcome	NOUN
bptjm-71	409	29	from	from	ADP
bptjm-71	409	30	the	the	DET
bptjm-71	409	31	first	first	ADJ
bptjm-71	409	32	clinical	clinical	ADJ
bptjm-71	409	33	trial	trial	NOUN
bptjm-71	409	34	of	of	ADP
bptjm-71	409	35	senolytic	senolytic	ADJ
bptjm-71	409	36	therapy	therapy	NOUN
bptjm-71	409	37	for	for	ADP
bptjm-71	409	38	alzheimer	alzheimer	PROPN
bptjm-71	409	39	's	's	PART
bptjm-71	409	40	disease	disease	NOUN
bptjm-71	409	41	.	.	PUNCT
bptjm-71	410	1	preprint.res	preprint.re	VERB
bptjm-71	410	2	sq	sq	PROPN
bptjm-71	410	3	.	.	PROPN
bptjm-71	410	4	2023	2023	NUM
bptjm-71	410	5	;	;	PUNCT
bptjm-71	410	6	rs.3	rs.3	PROPN
bptjm-71	410	7	.	.	PUNCT
bptjm-71	411	1	rs-2809973	rs-2809973	NOUN
bptjm-71	411	2	.	.	PUNCT
bptjm-71	412	1	published	publish	VERB
bptjm-71	412	2	2023	2023	NUM
bptjm-71	412	3	apr	apr	NOUN
bptjm-71	412	4	24	24	NUM
bptjm-71	412	5	.	.	PUNCT
bptjm-71	412	6	doi:10.21203	doi:10.21203	PROPN
bptjm-71	412	7	/	/	SYM
bptjm-71	412	8	rs.3.rs-2809973	rs.3.rs-2809973	NOUN
bptjm-71	412	9	/	/	SYM
bptjm-71	412	10	v1	v1	PROPN
bptjm-71	412	11	45	45	NUM
bptjm-71	412	12	.	.	PUNCT
bptjm-71	413	1	y	y	PROPN
bptjm-71	413	2	ousefzadehmj	ousefzadehmj	PROPN
bptjm-71	413	3	,	,	PUNCT
bptjm-71	413	4	zhu	zhu	PROPN
bptjm-71	413	5	y	y	PROPN
bptjm-71	413	6	,	,	PUNCT
bptjm-71	413	7	mcgowan	mcgowan	PROPN
bptjm-71	413	8	sj	sj	PROPN
bptjm-71	413	9	,	,	PUNCT
bptjm-71	413	10	et	et	PROPN
bptjm-71	413	11	al	al	PROPN
bptjm-71	413	12	.	.	PROPN
bptjm-71	413	13	fisetin	fisetin	PROPN
bptjm-71	413	14	is	be	AUX
bptjm-71	413	15	a	a	DET
bptjm-71	413	16	senotherapeutic	senotherapeutic	ADJ
bptjm-71	413	17	that	that	PRON
bptjm-71	413	18	extends	extend	VERB
bptjm-71	413	19	health	health	NOUN
bptjm-71	413	20	and	and	CCONJ
bptjm-71	413	21	lifespan	lifespan	PROPN
bptjm-71	413	22	.	.	PUNCT
bptjm-71	414	1	ebiomedicine	ebiomedicine	ADJ
bptjm-71	414	2	.	.	PUNCT
bptjm-71	415	1	2018	2018	NUM
bptjm-71	415	2	;	;	PUNCT
bptjm-71	415	3	36	36	NUM
bptjm-71	415	4	:	:	SYM
bptjm-71	415	5	18	18	NUM
bptjm-71	415	6	-	-	SYM
bptjm-71	415	7	28	28	NUM
bptjm-71	415	8	.	.	PUNCT
bptjm-71	416	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	416	2	/	/	SYM
bptjm-71	416	3	j.ebiom.2018.09.015	j.ebiom.2018.09.015	PROPN
bptjm-71	416	4	46	46	NUM
bptjm-71	416	5	.	.	PUNCT
bptjm-71	417	1	zhong	zhong	PROPN
bptjm-71	417	2	r	r	PROPN
bptjm-71	417	3	,	,	PUNCT
bptjm-71	417	4	miao	miao	PROPN
bptjm-71	417	5	l	l	PROPN
bptjm-71	417	6	,	,	PUNCT
bptjm-71	417	7	zhang	zhang	PROPN
bptjm-71	417	8	h	h	PROPN
bptjm-71	417	9	,	,	PUNCT
bptjm-71	417	10	et	et	PROPN
bptjm-71	417	11	al	al	PROPN
bptjm-71	417	12	.	.	PUNCT
bptjm-71	418	1	anti	anti	ADJ
bptjm-71	418	2	-	-	ADJ
bptjm-71	418	3	inflammatory	inflammatory	ADJ
bptjm-71	418	4	activity	activity	NOUN
bptjm-71	418	5	of	of	ADP
bptjm-71	418	6	flavonols	flavonol	NOUN
bptjm-71	418	7	via	via	ADP
bptjm-71	418	8	inhibiting	inhibit	VERB
bptjm-71	418	9	mapk	mapk	NOUN
bptjm-71	418	10	and	and	CCONJ
bptjm-71	418	11	nf	nf	NOUN
bptjm-71	418	12	-	-	PUNCT
bptjm-71	418	13	κb	κb	NOUN
bptjm-71	418	14	signaling	signal	VERB
bptjm-71	418	15	pathways	pathway	NOUN
bptjm-71	418	16	in	in	ADP
bptjm-71	418	17	raw264.7	raw264.7	PROPN
bptjm-71	418	18	macrophages	macrophage	NOUN
bptjm-71	418	19	.	.	PUNCT
bptjm-71	419	1	curr	curr	PROPN
bptjm-71	419	2	res	res	PROPN
bptjm-71	419	3	food	food	PROPN
bptjm-71	419	4	sci	sci	PROPN
bptjm-71	419	5	.	.	PROPN
bptjm-71	419	6	2022	2022	NUM
bptjm-71	419	7	;	;	PUNCT
bptjm-71	419	8	5	5	NUM
bptjm-71	419	9	:	:	SYM
bptjm-71	419	10	1176	1176	NUM
bptjm-71	419	11	-	-	SYM
bptjm-71	419	12	1184	1184	NUM
bptjm-71	419	13	.	.	PUNCT
bptjm-71	420	1	published	publish	VERB
bptjm-71	420	2	2022	2022	NUM
bptjm-71	420	3	jul	jul	PROPN
bptjm-71	420	4	20	20	NUM
bptjm-71	420	5	.	.	PUNCT
bptjm-71	421	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	421	2	/	/	SYM
bptjm-71	421	3	j.crfs.2022.07.007	j.crfs.2022.07.007	PROPN
bptjm-71	421	4	47	47	NUM
bptjm-71	421	5	.	.	PUNCT
bptjm-71	422	1	elsallabi	elsallabi	PROPN
bptjm-71	422	2	o	o	PROPN
bptjm-71	422	3	,	,	PUNCT
bptjm-71	422	4	patruno	patruno	VERB
bptjm-71	422	5	a	a	PRON
bptjm-71	422	6	,	,	PUNCT
bptjm-71	422	7	pesce	pesce	NOUN
bptjm-71	422	8	m	m	PROPN
bptjm-71	422	9	,	,	PUNCT
bptjm-71	422	10	cataldi	cataldi	ADJ
bptjm-71	422	11	a	a	PROPN
bptjm-71	422	12	,	,	PUNCT
bptjm-71	422	13	carradori	carradori	PROPN
bptjm-71	422	14	s	s	PROPN
bptjm-71	422	15	,	,	PUNCT
bptjm-71	422	16	gallorini	gallorini	NOUN
bptjm-71	422	17	m.	m.	NOUN
bptjm-71	422	18	fisetin	fisetin	NOUN
bptjm-71	422	19	as	as	ADP
bptjm-71	422	20	a	a	DET
bptjm-71	422	21	senotherapeutic	senotherapeutic	ADJ
bptjm-71	422	22	agent	agent	NOUN
bptjm-71	422	23	:	:	PUNCT
bptjm-71	422	24	biopharmaceutical	biopharmaceutical	ADJ
bptjm-71	422	25	properties	property	NOUN
bptjm-71	422	26	and	and	CCONJ
bptjm-71	422	27	crosstalk	crosstalk	VERB
bptjm-71	422	28	between	between	ADP
bptjm-71	422	29	cell	cell	NOUN
bptjm-71	422	30	senescence	senescence	NOUN
bptjm-71	422	31	and	and	CCONJ
bptjm-71	422	32	neuroprotection.molecules	neuroprotection.molecule	NOUN
bptjm-71	422	33	.	.	NOUN
bptjm-71	422	34	2022	2022	NUM
bptjm-71	422	35	;	;	PUNCT
bptjm-71	422	36	27(3	27(3	NUM
bptjm-71	422	37	):	):	PUNCT
bptjm-71	422	38	738	738	NUM
bptjm-71	422	39	.	.	PUNCT
bptjm-71	423	1	published	publish	VERB
bptjm-71	423	2	2022	2022	NUM
bptjm-71	423	3	jan	jan	PROPN
bptjm-71	423	4	23	23	NUM
bptjm-71	423	5	.	.	PUNCT
bptjm-71	424	1	doi:10.3390	doi:10.3390	NOUN
bptjm-71	424	2	/	/	SYM
bptjm-71	424	3	molecules27030738	molecules27030738	PROPN
bptjm-71	424	4	48	48	NUM
bptjm-71	424	5	.	.	PUNCT
bptjm-71	425	1	zhum	zhum	NOUN
bptjm-71	425	2	,	,	PUNCT
bptjm-71	425	3	meng	meng	PROPN
bptjm-71	425	4	p	p	PROPN
bptjm-71	425	5	,	,	PUNCT
bptjm-71	425	6	ling	ling	PROPN
bptjm-71	425	7	x	x	PRON
bptjm-71	425	8	,	,	PUNCT
bptjm-71	425	9	zhou	zhou	PROPN
bptjm-71	425	10	l.	l.	PROPN
bptjm-71	425	11	advancements	advancement	NOUN
bptjm-71	425	12	in	in	ADP
bptjm-71	425	13	therapeutic	therapeutic	ADJ
bptjm-71	425	14	drugs	drug	NOUN
bptjm-71	425	15	targeting	target	VERB
bptjm-71	425	16	of	of	ADP
bptjm-71	425	17	senescence	senescence	NOUN
bptjm-71	425	18	.	.	PUNCT
bptjm-71	426	1	ther	ther	PROPN
bptjm-71	426	2	adv	adv	PROPN
bptjm-71	426	3	chronic	chronic	ADJ
bptjm-71	426	4	dis	dis	PROPN
bptjm-71	426	5	.	.	PUNCT
bptjm-71	427	1	2020	2020	NUM
bptjm-71	427	2	;	;	PUNCT
bptjm-71	427	3	11	11	NUM
bptjm-71	427	4	:	:	SYM
bptjm-71	427	5	2040622320964125	2040622320964125	NUM
bptjm-71	427	6	.	.	PUNCT
bptjm-71	428	1	published	publish	VERB
bptjm-71	428	2	2020	2020	NUM
bptjm-71	428	3	oct	oct	PROPN
bptjm-71	428	4	13	13	NUM
bptjm-71	428	5	.	.	PUNCT
bptjm-71	428	6	doi:10.1177/2040622320964125	doi:10.1177/2040622320964125	NOUN
bptjm-71	428	7	49	49	NUM
bptjm-71	428	8	.	.	PUNCT
bptjm-71	429	1	lim	lim	PROPN
bptjm-71	429	2	s	s	PROPN
bptjm-71	429	3	,	,	PUNCT
bptjm-71	429	4	kim	kim	PROPN
bptjm-71	429	5	tj	tj	PROPN
bptjm-71	429	6	,	,	PUNCT
bptjm-71	429	7	kim	kim	PROPN
bptjm-71	429	8	yj	yj	PROPN
bptjm-71	429	9	,	,	PUNCT
bptjm-71	429	10	kim	kim	PROPN
bptjm-71	429	11	c	c	PROPN
bptjm-71	429	12	,	,	PUNCT
bptjm-71	429	13	ko	ko	PROPN
bptjm-71	429	14	sb	sb	PROPN
bptjm-71	429	15	,	,	PUNCT
bptjm-71	429	16	kim	kim	PROPN
bptjm-71	429	17	bs	bs	PROPN
bptjm-71	429	18	.	.	PUNCT
bptjm-71	430	1	senolytic	senolytic	ADJ
bptjm-71	430	2	therapy	therapy	NOUN
bptjm-71	430	3	for	for	ADP
bptjm-71	430	4	cerebral	cerebral	ADJ
bptjm-71	430	5	ischemia	ischemia	NOUN
bptjm-71	430	6	-	-	PUNCT
bptjm-71	430	7	reperfusion	reperfusion	NOUN
bptjm-71	430	8	injury	injury	NOUN
bptjm-71	430	9	.	.	PUNCT
bptjm-71	431	1	int	int	PROPN
bptjm-71	431	2	j	j	PROPN
bptjm-71	431	3	mol	mol	ADP
bptjm-71	431	4	sci	sci	PROPN
bptjm-71	431	5	.	.	PROPN
bptjm-71	431	6	2021	2021	NUM
bptjm-71	431	7	;	;	PUNCT
bptjm-71	431	8	22(21	22(21	NUM
bptjm-71	431	9	):	):	PUNCT
bptjm-71	431	10	11967	11967	NUM
bptjm-71	431	11	.	.	PUNCT
bptjm-71	432	1	published	publish	VERB
bptjm-71	432	2	2021	2021	NUM
bptjm-71	432	3	nov	nov	NOUN
bptjm-71	432	4	4	4	NUM
bptjm-71	432	5	.	.	PUNCT
bptjm-71	432	6	doi:10.3390	doi:10.3390	PROPN
bptjm-71	432	7	/	/	SYM
bptjm-71	432	8	ijms222111967	ijms222111967	PROPN
bptjm-71	432	9	50	50	NUM
bptjm-71	432	10	.	.	PUNCT
bptjm-71	433	1	mohamad	mohamad	PROPN
bptjm-71	433	2	anuar	anuar	PROPN
bptjm-71	433	3	nn	nn	PROPN
bptjm-71	433	4	,	,	PUNCT
bptjm-71	433	5	nor	nor	CCONJ
bptjm-71	433	6	hisamns	hisamn	NOUN
bptjm-71	433	7	,	,	PUNCT
bptjm-71	433	8	liew	liew	PROPN
bptjm-71	433	9	sl	sl	PROPN
bptjm-71	433	10	,	,	PUNCT
bptjm-71	433	11	ugusman	ugusman	ADJ
bptjm-71	433	12	a.	a.	PROPN
bptjm-71	433	13	clinical	clinical	PROPN
bptjm-71	433	14	review	review	PROPN
bptjm-71	433	15	:	:	PUNCT
bptjm-71	433	16	navitoclax	navitoclax	INTJ
bptjm-71	433	17	as	as	ADP
bptjm-71	433	18	a	a	DET
bptjm-71	433	19	pro	pro	ADJ
bptjm-71	433	20	-	-	ADJ
bptjm-71	433	21	apoptotic	apoptotic	ADJ
bptjm-71	433	22	and	and	CCONJ
bptjm-71	433	23	anti	anti	ADJ
bptjm-71	433	24	-	-	ADJ
bptjm-71	433	25	fibrotic	fibrotic	ADJ
bptjm-71	433	26	agent	agent	NOUN
bptjm-71	433	27	.	.	PUNCT
bptjm-71	434	1	front	front	ADJ
bptjm-71	434	2	pharmacol	pharmacol	PROPN
bptjm-71	434	3	.	.	PUNCT
bptjm-71	435	1	2020	2020	NUM
bptjm-71	435	2	;	;	PUNCT
bptjm-71	435	3	11	11	NUM
bptjm-71	435	4	:	:	SYM
bptjm-71	435	5	564108	564108	NUM
bptjm-71	435	6	.	.	PUNCT
bptjm-71	436	1	published	publish	VERB
bptjm-71	436	2	2020	2020	NUM
bptjm-71	436	3	nov	nov	PROPN
bptjm-71	436	4	26	26	NUM
bptjm-71	436	5	.	.	PUNCT
bptjm-71	437	1	doi:10.3389	doi:10.3389	PROPN
bptjm-71	437	2	/	/	SYM
bptjm-71	437	3	fphar.2020.564108	fphar.2020.564108	NUM
bptjm-71	437	4	51	51	NUM
bptjm-71	437	5	.	.	PUNCT
bptjm-71	438	1	tarantini	tarantini	PROPN
bptjm-71	438	2	s	s	PROPN
bptjm-71	438	3	,	,	PUNCT
bptjm-71	438	4	balasubramanian	balasubramanian	ADJ
bptjm-71	438	5	p	p	PROPN
bptjm-71	438	6	,	,	PUNCT
bptjm-71	438	7	delfavero	delfavero	PROPN
bptjm-71	438	8	j	j	PROPN
bptjm-71	438	9	,	,	PUNCT
bptjm-71	438	10	et	et	PROPN
bptjm-71	438	11	al	al	PROPN
bptjm-71	438	12	.	.	PUNCT
bptjm-71	438	13	treatment	treatment	NOUN
bptjm-71	438	14	with	with	ADP
bptjm-71	438	15	the	the	DET
bptjm-71	438	16	bcl-2	bcl-2	NOUN
bptjm-71	438	17	/	/	SYM
bptjm-71	438	18	bcl	bcl	PROPN
bptjm-71	438	19	-	-	PROPN
bptjm-71	438	20	xl	xl	PROPN
bptjm-71	438	21	inhibitor	inhibitor	NOUN
bptjm-71	438	22	senolytic	senolytic	ADJ
bptjm-71	438	23	drug	drug	NOUN
bptjm-71	438	24	abt263	abt263	PROPN
bptjm-71	438	25	/	/	SYM
bptjm-71	438	26	navitoclax	navitoclax	PROPN
bptjm-71	438	27	improves	improve	VERB
bptjm-71	438	28	functional	functional	ADJ
bptjm-71	438	29	hyperemia	hyperemia	NOUN
bptjm-71	438	30	in	in	ADP
bptjm-71	438	31	aged	aged	ADJ
bptjm-71	438	32	mice.geroscience	mice.geroscience	NOUN
bptjm-71	438	33	.	.	PUNCT
bptjm-71	439	1	berkeley	berkeley	PROPN
bptjm-71	439	2	pharma	pharma	PROPN
bptjm-71	439	3	tech	tech	PROPN
bptjm-71	439	4	journal	journal	NOUN
bptjm-71	439	5	of	of	ADP
bptjm-71	439	6	medicine	medicine	NOUN
bptjm-71	439	7	|73	|73	PROPN
bptjm-71	439	8	2021	2021	NUM
bptjm-71	439	9	;	;	PUNCT
bptjm-71	439	10	43(5	43(5	NUM
bptjm-71	439	11	):	):	PUNCT
bptjm-71	439	12	2427	2427	NUM
bptjm-71	439	13	-	-	SYM
bptjm-71	439	14	2440	2440	NUM
bptjm-71	439	15	.	.	PUNCT
bptjm-71	440	1	doi:10.1007	doi:10.1007	VERB
bptjm-71	440	2	/	/	SYM
bptjm-71	440	3	s11357	s11357	NOUN
bptjm-71	440	4	-	-	PUNCT
bptjm-71	440	5	021	021	NUM
bptjm-71	440	6	-	-	PUNCT
bptjm-71	440	7	00440	00440	NUM
bptjm-71	440	8	-	-	SYM
bptjm-71	440	9	z	z	NOUN
bptjm-71	440	10	52	52	NUM
bptjm-71	440	11	.	.	PUNCT
bptjm-71	441	1	fatt	fatt	PROPN
bptjm-71	441	2	mp	mp	PROPN
bptjm-71	441	3	,	,	PUNCT
bptjm-71	441	4	tran	tran	PROPN
bptjm-71	441	5	lm	lm	PROPN
bptjm-71	441	6	,	,	PUNCT
bptjm-71	441	7	v	v	X
bptjm-71	441	8	etere	etere	NOUN
bptjm-71	441	9	g	g	PROPN
bptjm-71	441	10	,	,	PUNCT
bptjm-71	441	11	et	et	PROPN
bptjm-71	441	12	al	al	PROPN
bptjm-71	441	13	.	.	PUNCT
bptjm-71	441	14	restoration	restoration	NOUN
bptjm-71	441	15	of	of	ADP
bptjm-71	441	16	hippocampal	hippocampal	ADJ
bptjm-71	441	17	neural	neural	ADJ
bptjm-71	441	18	precursor	precursor	NOUN
bptjm-71	441	19	function	function	NOUN
bptjm-71	441	20	by	by	ADP
bptjm-71	441	21	ablation	ablation	NOUN
bptjm-71	441	22	of	of	ADP
bptjm-71	441	23	senescent	senescent	ADJ
bptjm-71	441	24	cells	cell	NOUN
bptjm-71	441	25	in	in	ADP
bptjm-71	441	26	the	the	DET
bptjm-71	441	27	aging	age	VERB
bptjm-71	441	28	stem	stem	NOUN
bptjm-71	441	29	cell	cell	NOUN
bptjm-71	441	30	niche	niche	NOUN
bptjm-71	441	31	.	.	PUNCT
bptjm-71	442	1	stem	stem	NOUN
bptjm-71	442	2	cell	cell	NOUN
bptjm-71	442	3	reports	report	NOUN
bptjm-71	442	4	.	.	PUNCT
bptjm-71	443	1	2022	2022	NUM
bptjm-71	443	2	;	;	PUNCT
bptjm-71	443	3	17(2	17(2	NUM
bptjm-71	443	4	):	):	PUNCT
bptjm-71	443	5	259	259	NUM
bptjm-71	443	6	-	-	SYM
bptjm-71	443	7	275	275	NUM
bptjm-71	443	8	.	.	PUNCT
bptjm-71	444	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	444	2	/	/	SYM
bptjm-71	444	3	j.stemcr.2021.12.010	j.stemcr.2021.12.010	PROPN
bptjm-71	444	4	53	53	NUM
bptjm-71	444	5	.	.	PUNCT
bptjm-71	445	1	kirkland	kirkland	PROPN
bptjm-71	445	2	jl	jl	PROPN
bptjm-71	445	3	,	,	PUNCT
bptjm-71	445	4	tchkonia	tchkonia	PROPN
bptjm-71	445	5	t	t	PROPN
bptjm-71	445	6	,	,	PUNCT
bptjm-71	445	7	zhu	zhu	PROPN
bptjm-71	445	8	y	y	PROPN
bptjm-71	445	9	,	,	PUNCT
bptjm-71	445	10	niedernhofer	niedernhofer	VERB
bptjm-71	445	11	lj	lj	PROPN
bptjm-71	445	12	,	,	PUNCT
bptjm-71	445	13	robbins	robbins	PROPN
bptjm-71	445	14	pd	pd	PROPN
bptjm-71	445	15	.	.	PUNCT
bptjm-71	446	1	the	the	DET
bptjm-71	446	2	clinical	clinical	ADJ
bptjm-71	446	3	potential	potential	NOUN
bptjm-71	446	4	of	of	ADP
bptjm-71	446	5	senolytic	senolytic	ADJ
bptjm-71	446	6	drugs	drug	NOUN
bptjm-71	446	7	.	.	PUNCT
bptjm-71	447	1	j	j	PROPN
bptjm-71	447	2	am	be	AUX
bptjm-71	447	3	geriatr	geriatr	ADJ
bptjm-71	447	4	soc	soc	NOUN
bptjm-71	447	5	.	.	PUNCT
bptjm-71	448	1	2017	2017	NUM
bptjm-71	448	2	;	;	PUNCT
bptjm-71	448	3	65(10	65(10	ADV
bptjm-71	448	4	):	):	PUNCT
bptjm-71	448	5	2297	2297	NUM
bptjm-71	448	6	-	-	SYM
bptjm-71	448	7	2301	2301	NUM
bptjm-71	448	8	.	.	PUNCT
bptjm-71	449	1	doi:10.1111	doi:10.1111	PROPN
bptjm-71	449	2	/	/	SYM
bptjm-71	449	3	jgs.14969	jgs.14969	PROPN
bptjm-71	449	4	54	54	NUM
bptjm-71	449	5	.	.	PUNCT
bptjm-71	450	1	kirkland	kirkland	PROPN
bptjm-71	450	2	jl	jl	PROPN
bptjm-71	450	3	,	,	PUNCT
bptjm-71	450	4	tchkonia	tchkonia	NOUN
bptjm-71	450	5	t.	t.	NOUN
bptjm-71	450	6	senolytic	senolytic	ADJ
bptjm-71	450	7	drugs	drug	NOUN
bptjm-71	450	8	:	:	PUNCT
bptjm-71	450	9	from	from	ADP
bptjm-71	450	10	discovery	discovery	NOUN
bptjm-71	450	11	to	to	ADP
bptjm-71	450	12	translation	translation	NOUN
bptjm-71	450	13	.	.	PUNCT
bptjm-71	451	1	j	j	PROPN
bptjm-71	451	2	internmed	internme	VERB
bptjm-71	451	3	.	.	PUNCT
bptjm-71	452	1	2020	2020	NUM
bptjm-71	452	2	;	;	PUNCT
bptjm-71	452	3	288(5	288(5	NUM
bptjm-71	452	4	):	):	PUNCT
bptjm-71	452	5	518	518	NUM
bptjm-71	452	6	-	-	SYM
bptjm-71	452	7	536	536	NUM
bptjm-71	452	8	.	.	PUNCT
bptjm-71	453	1	doi:10.1111	doi:10.1111	ADJ
bptjm-71	453	2	/	/	SYM
bptjm-71	453	3	joim.13141	joim.13141	ADJ
bptjm-71	453	4	55	55	NUM
bptjm-71	453	5	.	.	PUNCT
bptjm-71	454	1	grosse	grosse	PROPN
bptjm-71	454	2	l	l	PROPN
bptjm-71	454	3	,	,	PUNCT
bptjm-71	454	4	wagner	wagner	PROPN
bptjm-71	454	5	n	n	CCONJ
bptjm-71	454	6	,	,	PUNCT
bptjm-71	454	7	emelyanov	emelyanov	NOUN
bptjm-71	454	8	a	a	NOUN
bptjm-71	454	9	,	,	PUNCT
bptjm-71	454	10	et	et	PROPN
bptjm-71	454	11	al	al	PROPN
bptjm-71	454	12	.	.	PROPN
bptjm-71	454	13	defined	define	VERB
bptjm-71	454	14	p16high	p16high	ADJ
bptjm-71	454	15	senescent	senescent	ADJ
bptjm-71	454	16	cell	cell	NOUN
bptjm-71	454	17	types	type	NOUN
bptjm-71	454	18	are	be	AUX
bptjm-71	454	19	indispensable	indispensable	ADJ
bptjm-71	454	20	for	for	ADP
bptjm-71	454	21	mouse	mouse	NOUN
bptjm-71	454	22	healthspan	healthspan	NOUN
bptjm-71	454	23	.	.	PUNCT
bptjm-71	455	1	cell	cell	NOUN
bptjm-71	455	2	metab	metab	NOUN
bptjm-71	455	3	.	.	PUNCT
bptjm-71	456	1	2020	2020	NUM
bptjm-71	456	2	;	;	PUNCT
bptjm-71	456	3	32(1	32(1	NUM
bptjm-71	456	4	):	):	PUNCT
bptjm-71	456	5	87	87	NUM
bptjm-71	456	6	-	-	SYM
bptjm-71	456	7	99	99	NUM
bptjm-71	456	8	.	.	PUNCT
bptjm-71	457	1	e6	e6	PROPN
bptjm-71	457	2	.	.	PUNCT
bptjm-71	458	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	458	2	/	/	SYM
bptjm-71	458	3	j.cmet.2020.05.002	j.cmet.2020.05.002	PROPN
bptjm-71	458	4	56	56	NUM
bptjm-71	458	5	.	.	PUNCT
bptjm-71	459	1	lee	lee	PROPN
bptjm-71	459	2	s	s	PROPN
bptjm-71	459	3	,	,	PUNCT
bptjm-71	459	4	wang	wang	PROPN
bptjm-71	459	5	ey	ey	PROPN
bptjm-71	459	6	,	,	PUNCT
bptjm-71	459	7	steinberg	steinberg	PROPN
bptjm-71	459	8	ab	ab	PROPN
bptjm-71	459	9	,	,	PUNCT
bptjm-71	459	10	walton	walton	PROPN
bptjm-71	459	11	cc	cc	PROPN
bptjm-71	459	12	,	,	PUNCT
bptjm-71	459	13	chinta	chinta	VERB
bptjm-71	459	14	sj	sj	PROPN
bptjm-71	459	15	,	,	PUNCT
bptjm-71	459	16	andersen	andersen	PROPN
bptjm-71	459	17	jk	jk	PROPN
bptjm-71	459	18	.	.	PUNCT
bptjm-71	460	1	a	a	DET
bptjm-71	460	2	guide	guide	NOUN
bptjm-71	460	3	to	to	PART
bptjm-71	460	4	senolytic	senolytic	ADJ
bptjm-71	460	5	intervention	intervention	NOUN
bptjm-71	460	6	in	in	ADP
bptjm-71	460	7	neurodegenerative	neurodegenerative	ADJ
bptjm-71	460	8	disease.mech	disease.mech	NUM
bptjm-71	460	9	ageing	age	VERB
bptjm-71	460	10	dev	dev	NOUN
bptjm-71	460	11	.	.	PROPN
bptjm-71	460	12	2021	2021	NUM
bptjm-71	460	13	;	;	PUNCT
bptjm-71	460	14	200	200	NUM
bptjm-71	460	15	:	:	SYM
bptjm-71	460	16	111585	111585	NUM
bptjm-71	460	17	.	.	PUNCT
bptjm-71	461	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	461	2	/	/	SYM
bptjm-71	461	3	j.mad.2021.111585	j.mad.2021.111585	PROPN
bptjm-71	461	4	57	57	NUM
bptjm-71	461	5	.	.	PUNCT
bptjm-71	461	6	luchsinger	luchsinger	PROPN
bptjm-71	461	7	,	,	PUNCT
bptjm-71	461	8	j.	j.	PROPN
bptjm-71	461	9	metformin	metformin	PROPN
bptjm-71	461	10	in	in	ADP
bptjm-71	461	11	alzheimer	alzheimer	PROPN
bptjm-71	461	12	's	's	PART
bptjm-71	461	13	dementia	dementia	NOUN
bptjm-71	461	14	prevention	prevention	NOUN
bptjm-71	461	15	(	(	PUNCT
bptjm-71	461	16	map	map	NOUN
bptjm-71	461	17	)	)	PUNCT
bptjm-71	461	18	.	.	PUNCT
bptjm-71	462	1	clinicaltrials.gov	clinicaltrials.gov	NOUN
bptjm-71	462	2	identifier	identifier	NOUN
bptjm-71	462	3	:	:	PUNCT
bptjm-71	462	4	nct04098666	nct04098666	ADJ
bptjm-71	462	5	.	.	PUNCT
bptjm-71	463	1	updated	update	VERB
bptjm-71	463	2	july	july	PROPN
bptjm-71	463	3	3	3	NUM
bptjm-71	463	4	,	,	PUNCT
bptjm-71	463	5	2023	2023	NUM
bptjm-71	463	6	.	.	PUNCT
bptjm-71	464	1	https://clinicaltrials.gov/study/nct0409	https://clinicaltrials.gov/study/nct0409	PROPN
bptjm-71	464	2	8666	8666	NUM
bptjm-71	464	3	58	58	NUM
bptjm-71	464	4	.	.	PUNCT
bptjm-71	465	1	dorrier	dorrier	PROPN
bptjm-71	465	2	ce	ce	PROPN
bptjm-71	465	3	,	,	PUNCT
bptjm-71	465	4	jones	jones	PROPN
bptjm-71	465	5	he	he	PRON
bptjm-71	465	6	,	,	PUNCT
bptjm-71	465	7	pintarić	pintarić	PROPN
bptjm-71	465	8	l	l	PROPN
bptjm-71	465	9	,	,	PUNCT
bptjm-71	465	10	siegenthaler	siegenthaler	PROPN
bptjm-71	465	11	ja	ja	PROPN
bptjm-71	465	12	,	,	PUNCT
bptjm-71	465	13	daneman	daneman	PROPN
bptjm-71	465	14	r.	r.	PROPN
bptjm-71	465	15	emerging	emerge	VERB
bptjm-71	465	16	roles	role	NOUN
bptjm-71	465	17	for	for	ADP
bptjm-71	465	18	cns	cns	NOUN
bptjm-71	465	19	fibroblasts	fibroblast	NOUN
bptjm-71	465	20	in	in	ADP
bptjm-71	465	21	health	health	NOUN
bptjm-71	465	22	,	,	PUNCT
bptjm-71	465	23	injury	injury	NOUN
bptjm-71	465	24	and	and	CCONJ
bptjm-71	465	25	disease.nature	disease.nature	NOUN
bptjm-71	465	26	reviews	review	NOUN
bptjm-71	465	27	neuroscience	neuroscience	NOUN
bptjm-71	465	28	.	.	PUNCT
bptjm-71	466	1	2021	2021	NUM
bptjm-71	466	2	;	;	PUNCT
bptjm-71	467	1	23(1	23(1	NUM
bptjm-71	467	2	):	):	PUNCT
bptjm-71	467	3	23	23	NUM
bptjm-71	467	4	-	-	SYM
bptjm-71	467	5	34	34	NUM
bptjm-71	467	6	.	.	PUNCT
bptjm-71	467	7	doi:10.1038	doi:10.1038	PROPN
bptjm-71	467	8	/	/	SYM
bptjm-71	467	9	s41583	s41583	NOUN
bptjm-71	467	10	-	-	PUNCT
bptjm-71	467	11	021	021	NUM
bptjm-71	467	12	-	-	PUNCT
bptjm-71	467	13	00525	00525	NUM
bptjm-71	467	14	-	-	PUNCT
bptjm-71	467	15	w	w	NOUN
bptjm-71	467	16	59	59	NUM
bptjm-71	467	17	.	.	PUNCT
bptjm-71	468	1	moiseeva	moiseeva	ADJ
bptjm-71	468	2	o	o	NOUN
bptjm-71	468	3	,	,	PUNCT
bptjm-71	468	4	deschênes	deschêne	NOUN
bptjm-71	468	5	-	-	PUNCT
bptjm-71	468	6	simard	simard	PROPN
bptjm-71	468	7	x	x	SYM
bptjm-71	468	8	,	,	PUNCT
bptjm-71	468	9	st	st	NOUN
bptjm-71	468	10	-	-	PUNCT
bptjm-71	468	11	germain	germain	PROPN
bptjm-71	468	12	e	e	NOUN
bptjm-71	468	13	,	,	PUNCT
bptjm-71	468	14	et	et	PROPN
bptjm-71	468	15	al	al	PROPN
bptjm-71	468	16	.	.	PROPN
bptjm-71	468	17	metformin	metformin	PROPN
bptjm-71	468	18	inhibits	inhibit	VERB
bptjm-71	468	19	the	the	DET
bptjm-71	468	20	senescence	senescence	NOUN
bptjm-71	468	21	-	-	PUNCT
bptjm-71	468	22	associated	associate	VERB
bptjm-71	468	23	secretory	secretory	ADJ
bptjm-71	468	24	phenotype	phenotype	NOUN
bptjm-71	468	25	by	by	ADP
bptjm-71	468	26	interfering	interfere	VERB
bptjm-71	468	27	with	with	ADP
bptjm-71	468	28	ikk	ikk	PROPN
bptjm-71	468	29	/	/	SYM
bptjm-71	468	30	nf	nf	NOUN
bptjm-71	468	31	-	-	PUNCT
bptjm-71	468	32	κb	κb	NOUN
bptjm-71	468	33	activation	activation	NOUN
bptjm-71	468	34	.	.	PUNCT
bptjm-71	469	1	aging	age	VERB
bptjm-71	469	2	cell	cell	NOUN
bptjm-71	469	3	.	.	PUNCT
bptjm-71	470	1	2013	2013	NUM
bptjm-71	470	2	;	;	PUNCT
bptjm-71	470	3	12(3	12(3	NUM
bptjm-71	470	4	):	):	PUNCT
bptjm-71	470	5	489	489	NUM
bptjm-71	470	6	-	-	PUNCT
bptjm-71	470	7	498	498	NUM
bptjm-71	470	8	.	.	PUNCT
bptjm-71	471	1	doi:10.1111	doi:10.1111	PROPN
bptjm-71	471	2	/	/	SYM
bptjm-71	471	3	acel.12075	acel.12075	PROPN
bptjm-71	471	4	60	60	NUM
bptjm-71	471	5	.	.	PUNCT
bptjm-71	472	1	anisimov	anisimov	PROPN
bptjm-71	472	2	vn	vn	PROPN
bptjm-71	472	3	,	,	PUNCT
bptjm-71	472	4	berstein	berstein	ADJ
bptjm-71	472	5	lm	lm	PROPN
bptjm-71	472	6	,	,	PUNCT
bptjm-71	472	7	popovich	popovich	PROPN
bptjm-71	472	8	ig	ig	PROPN
bptjm-71	472	9	,	,	PUNCT
bptjm-71	472	10	et	et	PROPN
bptjm-71	472	11	al	al	PROPN
bptjm-71	472	12	.	.	PUNCT
bptjm-71	473	1	if	if	SCONJ
bptjm-71	473	2	started	start	VERB
bptjm-71	473	3	early	early	ADV
bptjm-71	473	4	in	in	ADP
bptjm-71	473	5	life	life	NOUN
bptjm-71	473	6	,	,	PUNCT
bptjm-71	473	7	metformin	metformin	NOUN
bptjm-71	473	8	treatment	treatment	NOUN
bptjm-71	473	9	increases	increase	VERB
bptjm-71	473	10	life	life	NOUN
bptjm-71	473	11	span	span	NOUN
bptjm-71	473	12	and	and	CCONJ
bptjm-71	473	13	postpones	postpone	VERB
bptjm-71	473	14	tumors	tumor	NOUN
bptjm-71	473	15	in	in	ADP
bptjm-71	473	16	female	female	ADJ
bptjm-71	473	17	shrmice	shrmice	NOUN
bptjm-71	473	18	.	.	PUNCT
bptjm-71	474	1	aging	age	VERB
bptjm-71	474	2	(	(	PUNCT
bptjm-71	474	3	albany	albany	PROPN
bptjm-71	474	4	ny	ny	PROPN
bptjm-71	474	5	)	)	PUNCT
bptjm-71	474	6	.	.	PUNCT
bptjm-71	475	1	2011	2011	NUM
bptjm-71	475	2	;	;	PUNCT
bptjm-71	475	3	3(2	3(2	NUM
bptjm-71	475	4	):	):	PUNCT
bptjm-71	475	5	148	148	NUM
bptjm-71	475	6	-	-	SYM
bptjm-71	475	7	157	157	NUM
bptjm-71	475	8	.	.	PUNCT
bptjm-71	476	1	doi:10.18632	doi:10.18632	PROPN
bptjm-71	476	2	/	/	SYM
bptjm-71	476	3	aging.100273	aging.100273	PROPN
bptjm-71	476	4	61	61	NUM
bptjm-71	476	5	.	.	PUNCT
bptjm-71	477	1	fang	fang	PROPN
bptjm-71	477	2	j	j	PROPN
bptjm-71	477	3	,	,	PUNCT
bptjm-71	477	4	y	y	PROPN
bptjm-71	477	5	ang	ang	PROPN
bptjm-71	477	6	j	j	PROPN
bptjm-71	477	7	,	,	PUNCT
bptjm-71	477	8	wu	wu	PROPN
bptjm-71	477	9	x	x	PROPN
bptjm-71	477	10	,	,	PUNCT
bptjm-71	477	11	et	et	PROPN
bptjm-71	477	12	al	al	PROPN
bptjm-71	477	13	.	.	PROPN
bptjm-71	477	14	metformin	metformin	PROPN
bptjm-71	477	15	alleviates	alleviate	VERB
bptjm-71	477	16	human	human	ADJ
bptjm-71	477	17	cellular	cellular	ADJ
bptjm-71	477	18	aging	aging	NOUN
bptjm-71	477	19	by	by	ADP
bptjm-71	477	20	upregulating	upregulate	VERB
bptjm-71	477	21	the	the	DET
bptjm-71	477	22	endoplasmic	endoplasmic	ADJ
bptjm-71	477	23	reticulum	reticulum	NOUN
bptjm-71	477	24	glutathione	glutathione	NOUN
bptjm-71	477	25	peroxidase	peroxidase	NOUN
bptjm-71	477	26	7	7	NUM
bptjm-71	477	27	.	.	PUNCT
bptjm-71	477	28	aging	age	VERB
bptjm-71	477	29	cell	cell	NOUN
bptjm-71	477	30	.	.	PUNCT
bptjm-71	478	1	2018	2018	NUM
bptjm-71	478	2	;	;	PUNCT
bptjm-71	478	3	17(4	17(4	NUM
bptjm-71	478	4	):	):	PUNCT
bptjm-71	478	5	e12765	e12765	PROPN
bptjm-71	478	6	.	.	PUNCT
bptjm-71	479	1	doi:10.1111	doi:10.1111	PROPN
bptjm-71	479	2	/	/	PUNCT
bptjm-71	480	1	acel.12765	acel.12765	PROPN
bptjm-71	480	2	62	62	NUM
bptjm-71	480	3	.	.	PUNCT
bptjm-71	481	1	noren	noren	PROPN
bptjm-71	481	2	hooten	hooten	PROPN
bptjm-71	481	3	n	n	CCONJ
bptjm-71	481	4	,	,	PUNCT
bptjm-71	481	5	martin	martin	PROPN
bptjm-71	481	6	-	-	PUNCT
bptjm-71	481	7	montalvo	montalvo	PROPN
bptjm-71	481	8	a	a	PRON
bptjm-71	481	9	,	,	PUNCT
bptjm-71	481	10	dluzen	dluzen	VERB
bptjm-71	481	11	df	df	PROPN
bptjm-71	481	12	,	,	PUNCT
bptjm-71	481	13	et	et	PROPN
bptjm-71	481	14	al	al	PROPN
bptjm-71	481	15	.	.	PUNCT
bptjm-71	481	16	metformin	metformin	NOUN
bptjm-71	481	17	-	-	PUNCT
bptjm-71	481	18	mediated	mediate	VERB
bptjm-71	481	19	increase	increase	NOUN
bptjm-71	481	20	in	in	ADP
bptjm-71	481	21	dicer1	dicer1	NOUN
bptjm-71	481	22	regulates	regulate	VERB
bptjm-71	481	23	microrna	microrna	PROPN
bptjm-71	481	24	expression	expression	NOUN
bptjm-71	481	25	and	and	CCONJ
bptjm-71	481	26	cellular	cellular	ADJ
bptjm-71	481	27	senescence	senescence	NOUN
bptjm-71	481	28	.	.	PUNCT
bptjm-71	482	1	aging	age	VERB
bptjm-71	482	2	cell	cell	NOUN
bptjm-71	482	3	.	.	PUNCT
bptjm-71	483	1	2016	2016	NUM
bptjm-71	483	2	;	;	PUNCT
bptjm-71	483	3	15(3	15(3	NUM
bptjm-71	483	4	):	):	PUNCT
bptjm-71	483	5	572	572	NUM
bptjm-71	483	6	-	-	SYM
bptjm-71	483	7	581	581	NUM
bptjm-71	483	8	.	.	PUNCT
bptjm-71	484	1	doi:10.1111	doi:10.1111	ADJ
bptjm-71	484	2	/	/	SYM
bptjm-71	484	3	acel.12469	acel.12469	PROPN
bptjm-71	484	4	63	63	NUM
bptjm-71	484	5	.	.	PUNCT
bptjm-71	485	1	zhang	zhang	PROPN
bptjm-71	485	2	l	l	PROPN
bptjm-71	485	3	,	,	PUNCT
bptjm-71	485	4	pitcher	pitcher	PROPN
bptjm-71	485	5	le	le	PROPN
bptjm-71	485	6	,	,	PUNCT
bptjm-71	485	7	prahalad	prahalad	X
bptjm-71	485	8	v	v	NOUN
bptjm-71	485	9	,	,	PUNCT
bptjm-71	485	10	niedernhofer	niedernhofer	NOUN
bptjm-71	485	11	lj	lj	PROPN
bptjm-71	485	12	,	,	PUNCT
bptjm-71	485	13	robbins	robbins	PROPN
bptjm-71	485	14	pd	pd	PROPN
bptjm-71	485	15	.	.	PROPN
bptjm-71	485	16	targeting	target	VERB
bptjm-71	485	17	cellular	cellular	ADJ
bptjm-71	485	18	senescence	senescence	NOUN
bptjm-71	485	19	with	with	ADP
bptjm-71	485	20	senotherapeutics	senotherapeutic	NOUN
bptjm-71	485	21	:	:	PUNCT
bptjm-71	485	22	senolytics	senolytic	NOUN
bptjm-71	485	23	and	and	CCONJ
bptjm-71	485	24	senomorphics	senomorphic	NOUN
bptjm-71	485	25	.	.	PUNCT
bptjm-71	486	1	febs	febs	PROPN
bptjm-71	486	2	j.	j.	PROPN
bptjm-71	486	3	2023	2023	NUM
bptjm-71	486	4	;	;	PUNCT
bptjm-71	486	5	290(5	290(5	NUM
bptjm-71	486	6	):	):	PUNCT
bptjm-71	486	7	1362	1362	NUM
bptjm-71	486	8	-	-	SYM
bptjm-71	486	9	1383	1383	NUM
bptjm-71	486	10	.	.	PUNCT
bptjm-71	487	1	doi:10.1111	doi:10.1111	ADJ
bptjm-71	487	2	/	/	SYM
bptjm-71	487	3	febs.16350	febs.16350	PROPN
bptjm-71	487	4	64	64	NUM
bptjm-71	487	5	.	.	PUNCT
bptjm-71	488	1	y	y	PROPN
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bptjm-71	488	3	h	h	PROPN
bptjm-71	488	4	,	,	PUNCT
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bptjm-71	488	6	h	h	PROPN
bptjm-71	488	7	,	,	PUNCT
bptjm-71	488	8	ren	ren	PROPN
bptjm-71	488	9	j	j	PROPN
bptjm-71	488	10	,	,	PUNCT
bptjm-71	488	11	chen	chen	PROPN
bptjm-71	489	1	q	q	PROPN
bptjm-71	489	2	,	,	PUNCT
bptjm-71	489	3	chen	chen	PROPN
bptjm-71	489	4	zj	zj	PROPN
bptjm-71	489	5	.	.	PROPN
bptjm-71	489	6	cgas	cgas	PROPN
bptjm-71	489	7	is	be	AUX
bptjm-71	489	8	essential	essential	ADJ
bptjm-71	489	9	for	for	ADP
bptjm-71	489	10	cellular	cellular	ADJ
bptjm-71	489	11	senescence	senescence	NOUN
bptjm-71	489	12	.	.	PUNCT
bptjm-71	490	1	proc	proc	PROPN
bptjm-71	490	2	natl	natl	PROPN
bptjm-71	490	3	acad	acad	PROPN
bptjm-71	490	4	sci	sci	PROPN
bptjm-71	490	5	usa	usa	PROPN
bptjm-71	490	6	.	.	PROPN
bptjm-71	490	7	2017	2017	NUM
bptjm-71	490	8	;	;	PUNCT
bptjm-71	490	9	114(23	114(23	NOUN
bptjm-71	490	10	):	):	PUNCT
bptjm-71	490	11	e4612	e4612	NOUN
bptjm-71	490	12	-	-	PUNCT
bptjm-71	490	13	e4620	e4620	NOUN
bptjm-71	490	14	.	.	PUNCT
bptjm-71	491	1	doi:10.1073	doi:10.1073	PROPN
bptjm-71	491	2	/	/	SYM
bptjm-71	491	3	pnas.1705499114	pnas.1705499114	PROPN
bptjm-71	491	4	berkeley	berkeley	PROPN
bptjm-71	491	5	pharma	pharma	PROPN
bptjm-71	491	6	tech	tech	NOUN
bptjm-71	491	7	journal	journal	NOUN
bptjm-71	491	8	of	of	ADP
bptjm-71	491	9	medicine	medicine	NOUN
bptjm-71	491	10	|74	|74	NUM
bptjm-71	491	11	65	65	NUM
bptjm-71	491	12	.	.	PUNCT
bptjm-71	492	1	kimd	kimd	PROPN
bptjm-71	492	2	,	,	PUNCT
bptjm-71	492	3	nguyenmd	nguyenmd	ADV
bptjm-71	492	4	,	,	PUNCT
bptjm-71	492	5	dobbinmm	dobbinmm	PROPN
bptjm-71	492	6	,	,	PUNCT
bptjm-71	492	7	et	et	PROPN
bptjm-71	492	8	al	al	PROPN
bptjm-71	492	9	.	.	PUNCT
bptjm-71	492	10	sirt1	sirt1	PROPN
bptjm-71	492	11	deacetylase	deacetylase	NOUN
bptjm-71	492	12	protects	protect	VERB
bptjm-71	492	13	against	against	ADP
bptjm-71	492	14	neurodegeneration	neurodegeneration	NOUN
bptjm-71	492	15	in	in	ADP
bptjm-71	492	16	models	model	NOUN
bptjm-71	492	17	for	for	ADP
bptjm-71	492	18	alzheimer	alzheimer	PROPN
bptjm-71	492	19	's	's	PART
bptjm-71	492	20	disease	disease	NOUN
bptjm-71	492	21	and	and	CCONJ
bptjm-71	492	22	amyotrophic	amyotrophic	ADJ
bptjm-71	492	23	lateral	lateral	ADJ
bptjm-71	492	24	sclerosis	sclerosis	NOUN
bptjm-71	492	25	.	.	PUNCT
bptjm-71	493	1	embo	embo	PROPN
bptjm-71	493	2	j.	j.	PROPN
bptjm-71	493	3	2007	2007	NUM
bptjm-71	493	4	;	;	PUNCT
bptjm-71	493	5	26(13	26(13	NUM
bptjm-71	493	6	):	):	PUNCT
bptjm-71	493	7	3169	3169	NUM
bptjm-71	493	8	-	-	SYM
bptjm-71	493	9	3179	3179	NUM
bptjm-71	493	10	.	.	PUNCT
bptjm-71	494	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	494	2	/	/	SYM
bptjm-71	494	3	sj.emboj.7601758	sj.emboj.7601758	NOUN
bptjm-71	494	4	66	66	NUM
bptjm-71	494	5	.	.	PUNCT
bptjm-71	495	1	sovrani	sovrani	PROPN
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bptjm-71	495	3	,	,	PUNCT
bptjm-71	495	4	bobermin	bobermin	PROPN
bptjm-71	495	5	ld	ld	PROPN
bptjm-71	495	6	,	,	PUNCT
bptjm-71	495	7	santos	santos	PROPN
bptjm-71	495	8	cl	cl	PROPN
bptjm-71	495	9	,	,	PUNCT
bptjm-71	495	10	et	et	PROPN
bptjm-71	495	11	al	al	PROPN
bptjm-71	495	12	.	.	PUNCT
bptjm-71	496	1	effects	effect	NOUN
bptjm-71	496	2	of	of	ADP
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bptjm-71	496	4	-	-	PUNCT
bptjm-71	496	5	term	term	NOUN
bptjm-71	496	6	resveratrol	resveratrol	NOUN
bptjm-71	496	7	treatment	treatment	NOUN
bptjm-71	496	8	in	in	ADP
bptjm-71	496	9	hypothalamic	hypothalamic	ADJ
bptjm-71	496	10	astrocyte	astrocyte	NOUN
bptjm-71	496	11	cultures	culture	NOUN
bptjm-71	496	12	from	from	ADP
bptjm-71	496	13	aged	aged	ADJ
bptjm-71	496	14	rats	rat	NOUN
bptjm-71	496	15	.	.	PUNCT
bptjm-71	497	1	mol	mol	ADP
bptjm-71	497	2	cell	cell	NOUN
bptjm-71	497	3	biochem	biochem	NOUN
bptjm-71	497	4	.	.	PUNCT
bptjm-71	498	1	2023	2023	NUM
bptjm-71	498	2	;	;	PUNCT
bptjm-71	498	3	478(6	478(6	NUM
bptjm-71	498	4	):	):	PUNCT
bptjm-71	498	5	1205	1205	NUM
bptjm-71	498	6	-	-	SYM
bptjm-71	498	7	1216	1216	NUM
bptjm-71	498	8	.	.	PUNCT
bptjm-71	499	1	doi:10.1007	doi:10.1007	NOUN
bptjm-71	499	2	/	/	SYM
bptjm-71	499	3	s11010	s11010	PROPN
bptjm-71	499	4	-	-	PUNCT
bptjm-71	499	5	022	022	NUM
bptjm-71	499	6	-	-	PUNCT
bptjm-71	499	7	04585	04585	NUM
bptjm-71	499	8	-	-	SYM
bptjm-71	499	9	z	z	NOUN
bptjm-71	499	10	67	67	NUM
bptjm-71	499	11	.	.	PUNCT
bptjm-71	500	1	xia	xia	PROPN
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bptjm-71	500	3	,	,	PUNCT
bptjm-71	500	4	wang	wang	PROPN
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bptjm-71	500	6	,	,	PUNCT
bptjm-71	500	7	hu	hu	PROPN
bptjm-71	500	8	xs	xs	PROPN
bptjm-71	500	9	,	,	PUNCT
bptjm-71	501	1	et	et	PROPN
bptjm-71	501	2	al	al	PROPN
bptjm-71	501	3	.	.	PUNCT
bptjm-71	501	4	resveratrol	resveratrol	NOUN
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bptjm-71	501	6	endothelial	endothelial	ADJ
bptjm-71	501	7	progenitor	progenitor	NOUN
bptjm-71	501	8	cells	cell	NOUN
bptjm-71	501	9	senescence	senescence	VERB
bptjm-71	501	10	through	through	ADP
bptjm-71	501	11	augmentation	augmentation	NOUN
bptjm-71	501	12	of	of	ADP
bptjm-71	501	13	telomerase	telomerase	NOUN
bptjm-71	501	14	activity	activity	NOUN
bptjm-71	501	15	by	by	ADP
bptjm-71	501	16	akt	akt	PROPN
bptjm-71	501	17	-	-	PUNCT
bptjm-71	501	18	dependent	dependent	ADJ
bptjm-71	501	19	mechanisms	mechanism	NOUN
bptjm-71	501	20	.	.	PUNCT
bptjm-71	502	1	br	br	PROPN
bptjm-71	502	2	j	j	PROPN
bptjm-71	502	3	pharmacol	pharmacol	PROPN
bptjm-71	502	4	.	.	PROPN
bptjm-71	502	5	2008	2008	NUM
bptjm-71	502	6	;	;	PUNCT
bptjm-71	502	7	155(3	155(3	NUM
bptjm-71	502	8	):	):	PUNCT
bptjm-71	502	9	387	387	NUM
bptjm-71	502	10	-	-	SYM
bptjm-71	502	11	394	394	NUM
bptjm-71	502	12	.	.	PUNCT
bptjm-71	503	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	503	2	/	/	SYM
bptjm-71	503	3	bjp.2008.272	bjp.2008.272	NOUN
bptjm-71	503	4	68	68	NUM
bptjm-71	503	5	.	.	PUNCT
bptjm-71	504	1	alfatahm	alfatahm	PROPN
bptjm-71	504	2	,	,	PUNCT
bptjm-71	504	3	wong	wong	PROPN
bptjm-71	504	4	jh	jh	PROPN
bptjm-71	504	5	,	,	PUNCT
bptjm-71	504	6	krishnan	krishnan	PROPN
bptjm-71	504	7	vg	vg	PROPN
bptjm-71	504	8	,	,	PUNCT
bptjm-71	504	9	et	et	PROPN
bptjm-71	504	10	al	al	PROPN
bptjm-71	504	11	.	.	PUNCT
bptjm-71	505	1	torc1	torc1	PROPN
bptjm-71	505	2	regulates	regulate	VERB
bptjm-71	505	3	the	the	DET
bptjm-71	505	4	transcriptional	transcriptional	ADJ
bptjm-71	505	5	response	response	NOUN
bptjm-71	505	6	to	to	ADP
bptjm-71	505	7	glucose	glucose	NOUN
bptjm-71	505	8	and	and	CCONJ
bptjm-71	505	9	developmental	developmental	ADJ
bptjm-71	505	10	cycle	cycle	NOUN
bptjm-71	505	11	via	via	ADP
bptjm-71	505	12	the	the	DET
bptjm-71	505	13	tap42	tap42	NOUN
bptjm-71	505	14	-	-	PUNCT
bptjm-71	505	15	sit4	sit4	NOUN
bptjm-71	505	16	-	-	PUNCT
bptjm-71	505	17	rrd1/2	rrd1/2	PROPN
bptjm-71	505	18	pathway	pathway	NOUN
bptjm-71	505	19	in	in	ADP
bptjm-71	505	20	saccharomyces	saccharomyce	NOUN
bptjm-71	505	21	cerevisiae	cerevisiae	NOUN
bptjm-71	505	22	.	.	PUNCT
bptjm-71	506	1	bmc	bmc	PROPN
bptjm-71	506	2	biol	biol	PROPN
bptjm-71	506	3	.	.	PUNCT
bptjm-71	507	1	2021	2021	NUM
bptjm-71	507	2	;	;	PUNCT
bptjm-71	507	3	19(1	19(1	NUM
bptjm-71	507	4	):	):	PUNCT
bptjm-71	507	5	95	95	NUM
bptjm-71	507	6	.	.	PUNCT
bptjm-71	508	1	published	publish	VERB
bptjm-71	508	2	2021may	2021may	NUM
bptjm-71	508	3	6	6	NUM
bptjm-71	508	4	.	.	PUNCT
bptjm-71	508	5	doi:10.1186	doi:10.1186	PROPN
bptjm-71	508	6	/	/	SYM
bptjm-71	508	7	s12915	s12915	NOUN
bptjm-71	508	8	-	-	PUNCT
bptjm-71	508	9	021	021	NUM
bptjm-71	508	10	-	-	PUNCT
bptjm-71	508	11	01030	01030	NUM
bptjm-71	508	12	-	-	SYM
bptjm-71	508	13	3	3	NUM
bptjm-71	508	14	69	69	NUM
bptjm-71	508	15	.	.	PUNCT
bptjm-71	509	1	aulin	aulin	PROPN
bptjm-71	509	2	j	j	PROPN
bptjm-71	509	3	,	,	PUNCT
bptjm-71	509	4	hijazi	hijazi	PROPN
bptjm-71	509	5	z	z	NOUN
bptjm-71	509	6	,	,	PUNCT
bptjm-71	509	7	siegbahn	siegbahn	VERB
bptjm-71	509	8	a	a	DET
bptjm-71	509	9	,	,	PUNCT
bptjm-71	509	10	et	et	PROPN
bptjm-71	509	11	al	al	PROPN
bptjm-71	509	12	.	.	PROPN
bptjm-71	509	13	serial	serial	PROPN
bptjm-71	509	14	measurement	measurement	NOUN
bptjm-71	509	15	of	of	ADP
bptjm-71	509	16	interleukin-6	interleukin-6	NUM
bptjm-71	509	17	and	and	CCONJ
bptjm-71	509	18	risk	risk	NOUN
bptjm-71	509	19	of	of	ADP
bptjm-71	509	20	mortality	mortality	NOUN
bptjm-71	509	21	in	in	ADP
bptjm-71	509	22	anticoagulated	anticoagulate	VERB
bptjm-71	509	23	patients	patient	NOUN
bptjm-71	509	24	with	with	ADP
bptjm-71	509	25	atrial	atrial	ADJ
bptjm-71	509	26	fibrillation	fibrillation	NOUN
bptjm-71	509	27	:	:	PUNCT
bptjm-71	509	28	insights	insight	NOUN
bptjm-71	509	29	from	from	ADP
bptjm-71	509	30	aristotle	aristotle	PROPN
bptjm-71	509	31	and	and	CCONJ
bptjm-71	509	32	re	re	ADJ
bptjm-71	509	33	-	-	NOUN
bptjm-71	509	34	ly	ly	ADP
bptjm-71	509	35	trials	trial	NOUN
bptjm-71	509	36	.	.	PUNCT
bptjm-71	510	1	j	j	PROPN
bptjm-71	510	2	thromb	thromb	PROPN
bptjm-71	510	3	haemost	haemost	VERB
bptjm-71	510	4	.	.	PUNCT
bptjm-71	511	1	2020	2020	NUM
bptjm-71	511	2	;	;	PUNCT
bptjm-71	512	1	18(9	18(9	NUM
bptjm-71	512	2	):	):	PUNCT
bptjm-71	512	3	2287	2287	NUM
bptjm-71	512	4	-	-	SYM
bptjm-71	512	5	2295	2295	NUM
bptjm-71	512	6	.	.	PUNCT
bptjm-71	513	1	doi:10.1111	doi:10.1111	NOUN
bptjm-71	513	2	/	/	SYM
bptjm-71	513	3	jth.14947	jth.14947	NUM
bptjm-71	513	4	70	70	NUM
bptjm-71	513	5	.	.	PUNCT
bptjm-71	514	1	braidy	braidy	VERB
bptjm-71	514	2	n	n	PRON
bptjm-71	514	3	,	,	PUNCT
bptjm-71	514	4	liu	liu	PROPN
bptjm-71	514	5	y	y	PROPN
bptjm-71	514	6	.	.	PUNCT
bptjm-71	515	1	nad+	nad+	PROPN
bptjm-71	515	2	therapy	therapy	NOUN
bptjm-71	515	3	in	in	ADP
bptjm-71	515	4	age	age	NOUN
bptjm-71	515	5	-	-	PUNCT
bptjm-71	515	6	related	relate	VERB
bptjm-71	515	7	degenerative	degenerative	ADJ
bptjm-71	515	8	disorders	disorder	NOUN
bptjm-71	515	9	:	:	PUNCT
bptjm-71	515	10	a	a	DET
bptjm-71	515	11	benefit	benefit	NOUN
bptjm-71	515	12	/	/	SYM
bptjm-71	515	13	risk	risk	NOUN
bptjm-71	515	14	analysis	analysis	NOUN
bptjm-71	515	15	.	.	PUNCT
bptjm-71	516	1	exp	exp	NOUN
bptjm-71	516	2	gerontol	gerontol	NOUN
bptjm-71	516	3	.	.	PUNCT
bptjm-71	517	1	2020	2020	NUM
bptjm-71	517	2	;	;	PUNCT
bptjm-71	517	3	132	132	NUM
bptjm-71	517	4	:	:	SYM
bptjm-71	517	5	110831	110831	NUM
bptjm-71	517	6	.	.	PUNCT
bptjm-71	518	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	518	2	/	/	SYM
bptjm-71	518	3	j.exger.2020.110831	j.exger.2020.110831	PROPN
bptjm-71	518	4	71	71	NUM
bptjm-71	518	5	.	.	PUNCT
bptjm-71	519	1	y	y	PROPN
bptjm-71	519	2	ang	ang	PROPN
bptjm-71	519	3	b	b	PROPN
bptjm-71	519	4	,	,	PUNCT
bptjm-71	519	5	dan	dan	PROPN
bptjm-71	519	6	x	x	PROPN
bptjm-71	519	7	,	,	PUNCT
bptjm-71	519	8	hou	hou	PROPN
bptjm-71	519	9	y	y	PROPN
bptjm-71	519	10	,	,	PUNCT
bptjm-71	519	11	et	et	PROPN
bptjm-71	519	12	al	al	PROPN
bptjm-71	519	13	.	.	PUNCT
bptjm-71	520	1	nad+	nad+	PROPN
bptjm-71	520	2	supplementation	supplementation	NOUN
bptjm-71	520	3	prevents	prevent	VERB
bptjm-71	520	4	sting	sting	ADJ
bptjm-71	520	5	-	-	PUNCT
bptjm-71	520	6	induced	induce	VERB
bptjm-71	520	7	senescence	senescence	NOUN
bptjm-71	520	8	in	in	ADP
bptjm-71	520	9	ataxia	ataxia	NOUN
bptjm-71	520	10	telangiectasia	telangiectasia	NOUN
bptjm-71	520	11	by	by	ADP
bptjm-71	520	12	improving	improve	VERB
bptjm-71	520	13	mitophagy	mitophagy	NOUN
bptjm-71	520	14	.	.	PUNCT
bptjm-71	521	1	aging	age	VERB
bptjm-71	521	2	cell	cell	NOUN
bptjm-71	521	3	.	.	PUNCT
bptjm-71	522	1	2021	2021	NUM
bptjm-71	522	2	;	;	PUNCT
bptjm-71	523	1	20(4	20(4	NUM
bptjm-71	523	2	):	):	PUNCT
bptjm-71	523	3	e13329	e13329	NOUN
bptjm-71	523	4	.	.	PUNCT
bptjm-71	524	1	doi:10.1111	doi:10.1111	PROPN
bptjm-71	524	2	/	/	SYM
bptjm-71	525	1	acel.13329	acel.13329	PROPN
bptjm-71	525	2	72	72	NUM
bptjm-71	525	3	.	.	PUNCT
bptjm-71	526	1	hou	hou	PROPN
bptjm-71	526	2	y	y	PROPN
bptjm-71	526	3	,	,	PUNCT
bptjm-71	526	4	wei	wei	PROPN
bptjm-71	526	5	y	y	PROPN
bptjm-71	526	6	,	,	PUNCT
bptjm-71	526	7	lautrup	lautrup	NOUN
bptjm-71	526	8	s	s	PROPN
bptjm-71	526	9	,	,	PUNCT
bptjm-71	526	10	et	et	PROPN
bptjm-71	526	11	al	al	PROPN
bptjm-71	526	12	.	.	PUNCT
bptjm-71	527	1	nad+	nad+	PROPN
bptjm-71	527	2	supplementation	supplementation	NOUN
bptjm-71	527	3	reduces	reduce	VERB
bptjm-71	527	4	neuroinflammation	neuroinflammation	NOUN
bptjm-71	527	5	and	and	CCONJ
bptjm-71	527	6	cell	cell	NOUN
bptjm-71	527	7	senescence	senescence	NOUN
bptjm-71	527	8	in	in	ADP
bptjm-71	527	9	a	a	DET
bptjm-71	527	10	transgenic	transgenic	NOUN
bptjm-71	527	11	mouse	mouse	NOUN
bptjm-71	527	12	model	model	NOUN
bptjm-71	527	13	of	of	ADP
bptjm-71	527	14	alzheimer	alzheimer	PROPN
bptjm-71	527	15	's	's	PART
bptjm-71	527	16	disease	disease	NOUN
bptjm-71	527	17	via	via	ADP
bptjm-71	527	18	cgas	cgas	ADV
bptjm-71	527	19	-	-	PUNCT
bptjm-71	527	20	sting	sting	ADJ
bptjm-71	527	21	.	.	PUNCT
bptjm-71	528	1	proc	proc	PROPN
bptjm-71	528	2	natl	natl	PROPN
bptjm-71	528	3	acad	acad	PROPN
bptjm-71	528	4	sci	sci	PROPN
bptjm-71	528	5	usa	usa	PROPN
bptjm-71	528	6	.	.	PROPN
bptjm-71	528	7	2021	2021	NUM
bptjm-71	528	8	;	;	PUNCT
bptjm-71	528	9	118(37	118(37	NUM
bptjm-71	528	10	):	):	PUNCT
bptjm-71	528	11	e2011226118	e2011226118	X
bptjm-71	528	12	.	.	PUNCT
bptjm-71	529	1	doi:10.1073	doi:10.1073	PROPN
bptjm-71	529	2	/	/	SYM
bptjm-71	529	3	pnas.2011226118	pnas.2011226118	PROPN
bptjm-71	529	4	73	73	NUM
bptjm-71	529	5	.	.	PUNCT
bptjm-71	530	1	franci	franci	PROPN
bptjm-71	530	2	l	l	PROPN
bptjm-71	530	3	,	,	PUNCT
bptjm-71	530	4	tubita	tubita	PROPN
bptjm-71	530	5	a	a	X
bptjm-71	530	6	,	,	PUNCT
bptjm-71	530	7	bertolino	bertolino	PROPN
bptjm-71	530	8	fm	fm	PROPN
bptjm-71	530	9	,	,	PUNCT
bptjm-71	530	10	et	et	PROPN
bptjm-71	530	11	al	al	PROPN
bptjm-71	530	12	.	.	PROPN
bptjm-71	530	13	mapk15	mapk15	PROPN
bptjm-71	530	14	protects	protect	VERB
bptjm-71	530	15	from	from	ADP
bptjm-71	530	16	oxidative	oxidative	ADJ
bptjm-71	530	17	stress	stress	NOUN
bptjm-71	530	18	-	-	PUNCT
bptjm-71	530	19	dependent	dependent	ADJ
bptjm-71	530	20	cellular	cellular	ADJ
bptjm-71	530	21	senescence	senescence	NOUN
bptjm-71	530	22	by	by	ADP
bptjm-71	530	23	inducing	induce	VERB
bptjm-71	530	24	the	the	DET
bptjm-71	530	25	mitophagic	mitophagic	ADJ
bptjm-71	530	26	process	process	NOUN
bptjm-71	530	27	.	.	PUNCT
bptjm-71	531	1	aging	age	VERB
bptjm-71	531	2	cell	cell	NOUN
bptjm-71	531	3	.	.	PUNCT
bptjm-71	532	1	2022	2022	NUM
bptjm-71	532	2	;	;	PUNCT
bptjm-71	532	3	21(7	21(7	NUM
bptjm-71	532	4	):	):	PUNCT
bptjm-71	532	5	e13620	e13620	NOUN
bptjm-71	532	6	.	.	PUNCT
bptjm-71	533	1	doi:10.1111	doi:10.1111	PROPN
bptjm-71	533	2	/	/	SYM
bptjm-71	533	3	acel.13620	acel.13620	PROPN
bptjm-71	533	4	74	74	NUM
bptjm-71	533	5	.	.	PUNCT
bptjm-71	534	1	gui	gui	PROPN
bptjm-71	534	2	c	c	PROPN
bptjm-71	534	3	,	,	PUNCT
bptjm-71	534	4	ren	ren	PROPN
bptjm-71	534	5	y	y	PROPN
bptjm-71	534	6	,	,	PUNCT
bptjm-71	534	7	chen	chen	PROPN
bptjm-71	534	8	j	j	PROPN
bptjm-71	534	9	,	,	PUNCT
bptjm-71	534	10	et	et	PROPN
bptjm-71	534	11	al	al	PROPN
bptjm-71	534	12	.	.	PROPN
bptjm-71	535	1	p38	p38	PROPN
bptjm-71	535	2	mapk	mapk	NOUN
bptjm-71	535	3	-	-	PUNCT
bptjm-71	535	4	drp1	drp1	NOUN
bptjm-71	535	5	signaling	signal	VERB
bptjm-71	535	6	is	be	AUX
bptjm-71	535	7	involved	involve	VERB
bptjm-71	535	8	in	in	ADP
bptjm-71	535	9	mitochondrial	mitochondrial	ADJ
bptjm-71	535	10	dysfunction	dysfunction	NOUN
bptjm-71	535	11	and	and	CCONJ
bptjm-71	535	12	cell	cell	NOUN
bptjm-71	535	13	death	death	NOUN
bptjm-71	535	14	in	in	ADP
bptjm-71	535	15	mutant	mutant	ADJ
bptjm-71	535	16	a53	a53	PROPN
bptjm-71	535	17	t	t	PROPN
bptjm-71	535	18	α	α	PROPN
bptjm-71	535	19	-	-	PUNCT
bptjm-71	535	20	synuclein	synuclein	NOUN
bptjm-71	535	21	model	model	NOUN
bptjm-71	535	22	of	of	ADP
bptjm-71	535	23	parkinson	parkinson	NOUN
bptjm-71	535	24	's	's	PART
bptjm-71	535	25	disease	disease	NOUN
bptjm-71	535	26	.	.	PUNCT
bptjm-71	536	1	toxicol	toxicol	PROPN
bptjm-71	536	2	appl	appl	PROPN
bptjm-71	536	3	pharmacol	pharmacol	PROPN
bptjm-71	536	4	.	.	PUNCT
bptjm-71	537	1	2020	2020	NUM
bptjm-71	537	2	;	;	PUNCT
bptjm-71	537	3	388	388	NUM
bptjm-71	537	4	:	:	SYM
bptjm-71	537	5	114874	114874	NUM
bptjm-71	537	6	.	.	PUNCT
bptjm-71	538	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	538	2	/	/	SYM
bptjm-71	538	3	j.taap.2019.114874	j.taap.2019.114874	PROPN
bptjm-71	538	4	75	75	NUM
bptjm-71	538	5	.	.	PUNCT
bptjm-71	539	1	freund	freund	PROPN
bptjm-71	539	2	a	a	PRON
bptjm-71	539	3	,	,	PUNCT
bptjm-71	539	4	patil	patil	PROPN
bptjm-71	539	5	ck	ck	PROPN
bptjm-71	539	6	,	,	PUNCT
bptjm-71	539	7	campisi	campisi	PROPN
bptjm-71	539	8	j.	j.	PROPN
bptjm-71	539	9	p38mapk	p38mapk	PROPN
bptjm-71	539	10	is	be	AUX
bptjm-71	539	11	a	a	DET
bptjm-71	539	12	novel	novel	ADJ
bptjm-71	539	13	dna	dna	NOUN
bptjm-71	539	14	damage	damage	NOUN
bptjm-71	539	15	response	response	NOUN
bptjm-71	539	16	-	-	PUNCT
bptjm-71	539	17	independent	independent	ADJ
bptjm-71	539	18	regulator	regulator	NOUN
bptjm-71	539	19	of	of	ADP
bptjm-71	539	20	the	the	DET
bptjm-71	539	21	senescence	senescence	NOUN
bptjm-71	539	22	-	-	PUNCT
bptjm-71	539	23	associated	associate	VERB
bptjm-71	539	24	secretory	secretory	ADJ
bptjm-71	539	25	phenotype	phenotype	NOUN
bptjm-71	539	26	.	.	PUNCT
bptjm-71	540	1	embo	embo	PROPN
bptjm-71	540	2	j.	j.	PROPN
bptjm-71	540	3	2011	2011	NUM
bptjm-71	540	4	;	;	PUNCT
bptjm-71	540	5	30(8	30(8	NUM
bptjm-71	540	6	):	):	PUNCT
bptjm-71	540	7	1536	1536	NUM
bptjm-71	540	8	-	-	SYM
bptjm-71	540	9	1548	1548	NUM
bptjm-71	540	10	.	.	PUNCT
bptjm-71	541	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	541	2	/	/	SYM
bptjm-71	541	3	emboj.2011.69	emboj.2011.69	NOUN
bptjm-71	541	4	76	76	NUM
bptjm-71	541	5	.	.	PUNCT
bptjm-71	542	1	wudd	wudd	PROPN
bptjm-71	542	2	,	,	PUNCT
bptjm-71	542	3	dai	dai	PROPN
bptjm-71	542	4	lj	lj	PROPN
bptjm-71	542	5	,	,	PUNCT
bptjm-71	542	6	tan	tan	PROPN
bptjm-71	542	7	hw	hw	AUX
bptjm-71	542	8	,	,	PUNCT
bptjm-71	542	9	et	et	PROPN
bptjm-71	542	10	al	al	PROPN
bptjm-71	542	11	.	.	PUNCT
bptjm-71	542	12	transcriptional	transcriptional	ADJ
bptjm-71	542	13	upregulation	upregulation	NOUN
bptjm-71	542	14	of	of	ADP
bptjm-71	542	15	mapk15	mapk15	NOUN
bptjm-71	542	16	by	by	ADP
bptjm-71	542	17	nf	nf	NOUN
bptjm-71	542	18	-	-	PUNCT
bptjm-71	542	19	κb	κb	NOUN
bptjm-71	542	20	signaling	signal	VERB
bptjm-71	542	21	boosts	boost	NOUN
bptjm-71	542	22	the	the	DET
bptjm-71	542	23	efficacy	efficacy	NOUN
bptjm-71	542	24	of	of	ADP
bptjm-71	542	25	combination	combination	NOUN
bptjm-71	542	26	therapy	therapy	NOUN
bptjm-71	542	27	with	with	ADP
bptjm-71	542	28	cisplatin	cisplatin	NOUN
bptjm-71	542	29	and	and	CCONJ
bptjm-71	542	30	tnf	tnf	PROPN
bptjm-71	542	31	-	-	PUNCT
bptjm-71	542	32	α	α	PROPN
bptjm-71	542	33	.	.	PUNCT
bptjm-71	543	1	iscience	iscience	NOUN
bptjm-71	543	2	.	.	PUNCT
bptjm-71	544	1	2022	2022	NUM
bptjm-71	544	2	;	;	PUNCT
bptjm-71	544	3	25(12	25(12	NUM
bptjm-71	544	4	):	):	PUNCT
bptjm-71	544	5	105459	105459	NUM
bptjm-71	544	6	.	.	PUNCT
bptjm-71	545	1	published	publish	VERB
bptjm-71	545	2	2022	2022	NUM
bptjm-71	545	3	oct	oct	PROPN
bptjm-71	545	4	28	28	NUM
bptjm-71	545	5	.	.	PUNCT
bptjm-71	546	1	doi:10.1016	doi:10.1016	PROPN
bptjm-71	546	2	/	/	SYM
bptjm-71	546	3	j.isci.2022.105459	j.isci.2022.105459	PROPN
bptjm-71	546	4	berkeley	berkeley	PROPN
bptjm-71	546	5	pharma	pharma	PROPN
bptjm-71	546	6	tech	tech	NOUN
bptjm-71	546	7	journal	journal	NOUN
bptjm-71	546	8	of	of	ADP
bptjm-71	546	9	medicine	medicine	NOUN
bptjm-71	546	10	|75	|75	PROPN
bptjm-71	546	11	77	77	NUM
bptjm-71	546	12	.	.	PUNCT
bptjm-71	547	1	wudd	wudd	PROPN
bptjm-71	547	2	,	,	PUNCT
bptjm-71	547	3	lau	lau	PROPN
bptjm-71	547	4	a	a	DET
bptjm-71	547	5	ty	ty	INTJ
bptjm-71	547	6	,	,	PUNCT
bptjm-71	547	7	y	y	PROPN
bptjm-71	547	8	u	u	PROPN
bptjm-71	547	9	fy	fy	PROPN
bptjm-71	547	10	,	,	PUNCT
bptjm-71	547	11	et	et	PROPN
bptjm-71	547	12	al	al	PROPN
bptjm-71	547	13	.	.	PROPN
bptjm-71	547	14	extracellular	extracellular	ADJ
bptjm-71	547	15	signal	signal	NOUN
bptjm-71	547	16	-	-	PUNCT
bptjm-71	547	17	regulated	regulate	VERB
bptjm-71	547	18	kinase	kinase	NOUN
bptjm-71	547	19	8	8	NUM
bptjm-71	547	20	-	-	PUNCT
bptjm-71	547	21	mediated	mediate	VERB
bptjm-71	547	22	nf	nf	ADJ
bptjm-71	547	23	-	-	PUNCT
bptjm-71	547	24	κb	κb	NOUN
bptjm-71	547	25	activation	activation	NOUN
bptjm-71	547	26	increases	increase	VERB
bptjm-71	547	27	sensitivity	sensitivity	NOUN
bptjm-71	547	28	of	of	ADP
bptjm-71	547	29	human	human	ADJ
bptjm-71	547	30	lung	lung	NOUN
bptjm-71	547	31	cancer	cancer	NOUN
bptjm-71	547	32	cells	cell	NOUN
bptjm-71	547	33	to	to	PART
bptjm-71	547	34	arsenic	arsenic	VERB
bptjm-71	547	35	trioxide.oncotarget	trioxide.oncotarget	NOUN
bptjm-71	547	36	.	.	PROPN
bptjm-71	547	37	2017	2017	NUM
bptjm-71	547	38	;	;	PUNCT
bptjm-71	547	39	8(30	8(30	NUM
bptjm-71	547	40	):	):	PUNCT
bptjm-71	547	41	49144	49144	NUM
bptjm-71	547	42	-	-	SYM
bptjm-71	547	43	49155	49155	NUM
bptjm-71	547	44	.	.	PUNCT
bptjm-71	548	1	doi:10.18632	doi:10.18632	PROPN
bptjm-71	548	2	/	/	SYM
bptjm-71	548	3	oncotarget.17100	oncotarget.17100	PROPN
bptjm-71	548	4	78	78	NUM
bptjm-71	548	5	.	.	PUNCT
bptjm-71	549	1	zhangm	zhangm	PROPN
bptjm-71	549	2	,	,	PUNCT
bptjm-71	549	3	fang	fang	X
bptjm-71	549	4	l	l	PROPN
bptjm-71	549	5	,	,	PUNCT
bptjm-71	549	6	zhou	zhou	PROPN
bptjm-71	549	7	l	l	PROPN
bptjm-71	549	8	,	,	PUNCT
bptjm-71	549	9	et	et	PROPN
bptjm-71	549	10	al	al	PROPN
bptjm-71	549	11	.	.	PROPN
bptjm-71	549	12	mapk15	mapk15	PROPN
bptjm-71	549	13	-	-	PUNCT
bptjm-71	549	14	ulk1	ulk1	PROPN
bptjm-71	549	15	signaling	signal	VERB
bptjm-71	549	16	regulates	regulate	VERB
bptjm-71	549	17	mitophagy	mitophagy	NOUN
bptjm-71	549	18	of	of	ADP
bptjm-71	549	19	airway	airway	NOUN
bptjm-71	549	20	epithelial	epithelial	ADJ
bptjm-71	549	21	cell	cell	NOUN
bptjm-71	549	22	in	in	ADP
bptjm-71	549	23	chronic	chronic	ADJ
bptjm-71	549	24	obstructive	obstructive	ADJ
bptjm-71	549	25	pulmonary	pulmonary	ADJ
bptjm-71	549	26	disease	disease	NOUN
bptjm-71	549	27	.	.	PUNCT
bptjm-71	550	1	free	free	ADJ
bptjm-71	550	2	radic	radic	ADJ
bptjm-71	550	3	biol	biol	PROPN
bptjm-71	550	4	med	me	VERB
bptjm-71	550	5	.	.	PUNCT
bptjm-71	550	6	2021	2021	NUM
bptjm-71	550	7	;	;	PUNCT
bptjm-71	551	1	172	172	NUM
bptjm-71	551	2	:	:	SYM
bptjm-71	551	3	541	541	NUM
bptjm-71	551	4	-	-	SYM
bptjm-71	551	5	549	549	NUM
bptjm-71	551	6	.	.	PUNCT
bptjm-71	551	7	doi:10.1016	doi:10.1016	PROPN
bptjm-71	551	8	/	/	SYM
bptjm-71	551	9	j.freeradbiomed.2021.07.004	j.freeradbiomed.2021.07.004	PROPN
bptjm-71	551	10	79	79	NUM
bptjm-71	551	11	.	.	PUNCT
bptjm-71	552	1	poblocka	poblocka	PROPN
bptjm-71	552	2	m	m	PROPN
bptjm-71	552	3	,	,	PUNCT
bptjm-71	552	4	bassey	bassey	PROPN
bptjm-71	552	5	al	al	PROPN
bptjm-71	552	6	,	,	PUNCT
bptjm-71	552	7	smith	smith	PROPN
bptjm-71	552	8	vm	vm	PROPN
bptjm-71	552	9	,	,	PUNCT
bptjm-71	552	10	et	et	PROPN
bptjm-71	552	11	al	al	PROPN
bptjm-71	552	12	.	.	PROPN
bptjm-71	553	1	targeted	target	VERB
bptjm-71	553	2	clearance	clearance	NOUN
bptjm-71	553	3	of	of	ADP
bptjm-71	553	4	senescent	senescent	ADJ
bptjm-71	553	5	cells	cell	NOUN
bptjm-71	553	6	using	use	VERB
bptjm-71	553	7	an	an	DET
bptjm-71	553	8	antibody	antibody	NOUN
bptjm-71	553	9	-	-	PUNCT
bptjm-71	553	10	drug	drug	NOUN
bptjm-71	553	11	conjugate	conjugate	NOUN
bptjm-71	553	12	against	against	ADP
bptjm-71	553	13	a	a	DET
bptjm-71	553	14	specific	specific	ADJ
bptjm-71	553	15	membrane	membrane	NOUN
bptjm-71	553	16	marker	marker	NOUN
bptjm-71	553	17	.	.	PUNCT
bptjm-71	554	1	sci	sci	PROPN
bptjm-71	554	2	rep	rep	PROPN
bptjm-71	554	3	.	.	PROPN
bptjm-71	554	4	2021	2021	NUM
bptjm-71	554	5	;	;	PUNCT
bptjm-71	554	6	11(1	11(1	NUM
bptjm-71	554	7	):	):	PUNCT
bptjm-71	554	8	20358	20358	NUM
bptjm-71	554	9	.	.	PUNCT
bptjm-71	555	1	published	publish	VERB
bptjm-71	555	2	2021	2021	NUM
bptjm-71	555	3	oct	oct	NOUN
bptjm-71	555	4	13	13	NUM
bptjm-71	555	5	.	.	PUNCT
bptjm-71	556	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	556	2	/	/	SYM
bptjm-71	556	3	s41598	s41598	NOUN
bptjm-71	556	4	-	-	PUNCT
bptjm-71	556	5	021	021	NUM
bptjm-71	556	6	-	-	PUNCT
bptjm-71	556	7	99852	99852	NUM
bptjm-71	556	8	-	-	SYM
bptjm-71	556	9	2	2	NUM
bptjm-71	556	10	80	80	NUM
bptjm-71	556	11	.	.	PUNCT
bptjm-71	557	1	amor	amor	PROPN
bptjm-71	557	2	c	c	PROPN
bptjm-71	557	3	,	,	PUNCT
bptjm-71	557	4	feucht	feucht	PROPN
bptjm-71	557	5	j	j	PROPN
bptjm-71	557	6	,	,	PUNCT
bptjm-71	557	7	leibold	leibold	VERB
bptjm-71	557	8	j	j	PROPN
bptjm-71	557	9	,	,	PUNCT
bptjm-71	557	10	et	et	PROPN
bptjm-71	557	11	al	al	PROPN
bptjm-71	557	12	.	.	PROPN
bptjm-71	558	1	senolytic	senolytic	ADJ
bptjm-71	558	2	cart	cart	NOUN
bptjm-71	558	3	cells	cell	NOUN
bptjm-71	558	4	reverse	reverse	VERB
bptjm-71	558	5	senescence	senescence	NOUN
bptjm-71	558	6	-	-	PUNCT
bptjm-71	558	7	associated	associate	VERB
bptjm-71	558	8	pathologies.nature	pathologies.nature	NOUN
bptjm-71	558	9	.	.	PUNCT
bptjm-71	558	10	2020	2020	NUM
bptjm-71	558	11	;	;	PUNCT
bptjm-71	558	12	583(7814	583(7814	NUM
bptjm-71	558	13	):	):	PUNCT
bptjm-71	558	14	127	127	NUM
bptjm-71	558	15	-	-	SYM
bptjm-71	558	16	132	132	NUM
bptjm-71	558	17	.	.	PUNCT
bptjm-71	559	1	doi:10.1038	doi:10.1038	NOUN
bptjm-71	559	2	/	/	SYM
bptjm-71	559	3	s41586	s41586	PROPN
bptjm-71	559	4	-	-	PUNCT
bptjm-71	559	5	020	020	NUM
bptjm-71	559	6	-	-	PUNCT
bptjm-71	559	7	2403	2403	NUM
bptjm-71	559	8	-	-	SYM
bptjm-71	559	9	9	9	NUM
bptjm-71	559	10	berkeley	berkeley	PROPN
bptjm-71	559	11	pharma	pharma	PROPN
bptjm-71	559	12	tech	tech	NOUN
bptjm-71	559	13	journal	journal	NOUN
bptjm-71	559	14	of	of	ADP
bptjm-71	559	15	medicine	medicine	PROPN
bptjm-71	559	16	|76	|76	PROPN