id	sid	tid	token	lemma	pos
bibechana-21109	1	1	microsoft	microsoft	PROPN
bibechana-21109	1	2	word	word	PROPN
bibechana-21109	1	3	lamichhane	lamichhane	PROPN
bibechana-21109	1	4	final	final	ADJ
bibechana-21109	1	5	(	(	PUNCT
bibechana-21109	1	6	79	79	NUM
bibechana-21109	1	7	-	-	SYM
bibechana-21109	1	8	91	91	NUM
bibechana-21109	1	9	)	)	PUNCT
bibechana-21109	1	10	tika	tika	NOUN
bibechana-21109	1	11	ram	ram	NOUN
bibechana-21109	1	12	lamichhane	lamichhane	NOUN
bibechana-21109	1	13	et	et	PROPN
bibechana-21109	1	14	al./	al./	ADV
bibechana-21109	1	15	bibechana	bibechana	PROPN
bibechana-21109	1	16	16	16	NUM
bibechana-21109	1	17	(	(	PUNCT
bibechana-21109	1	18	2019	2019	NUM
bibechana-21109	1	19	)	)	PUNCT
bibechana-21109	1	20	79	79	NUM
bibechana-21109	1	21	-	-	SYM
bibechana-21109	1	22	91	91	NUM
bibechana-21109	1	23	:	:	PUNCT
bibechana-21109	1	24	rcost	rcost	NOUN
bibechana-21109	1	25	p.79	p.79	ADP
bibechana-21109	1	26	(	(	PUNCT
bibechana-21109	1	27	online	online	ADJ
bibechana-21109	1	28	publication	publication	NOUN
bibechana-21109	1	29	:	:	PUNCT
bibechana-21109	1	30	dec	dec	PROPN
bibechana-21109	1	31	.	.	PROPN
bibechana-21109	1	32	,	,	PUNCT
bibechana-21109	1	33	2018	2018	NUM
bibechana-21109	1	34	)	)	PUNCT
bibechana-21109	1	35	bibechana	bibechana	NOUN
bibechana-21109	1	36	a	a	DET
bibechana-21109	1	37	multidisciplinary	multidisciplinary	ADJ
bibechana-21109	1	38	journal	journal	NOUN
bibechana-21109	1	39	of	of	ADP
bibechana-21109	1	40	science	science	NOUN
bibechana-21109	1	41	,	,	PUNCT
bibechana-21109	1	42	technology	technology	NOUN
bibechana-21109	1	43	and	and	CCONJ
bibechana-21109	1	44	mathematics	mathematic	NOUN
bibechana-21109	1	45	issn	issn	VERB
bibechana-21109	1	46	2091	2091	NUM
bibechana-21109	1	47	-	-	SYM
bibechana-21109	1	48	0762	0762	NUM
bibechana-21109	1	49	(	(	PUNCT
bibechana-21109	1	50	print	print	NOUN
bibechana-21109	1	51	)	)	PUNCT
bibechana-21109	1	52	,	,	PUNCT
bibechana-21109	1	53	2382	2382	NUM
bibechana-21109	1	54	-	-	SYM
bibechana-21109	1	55	5340	5340	NUM
bibechana-21109	1	56	(	(	PUNCT
bibechana-21109	1	57	0nline	0nline	NUM
bibechana-21109	1	58	)	)	PUNCT
bibechana-21109	1	59	journal	journal	NOUN
bibechana-21109	1	60	homepage	homepage	NOUN
bibechana-21109	1	61	:	:	PUNCT
bibechana-21109	1	62	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-21109	1	63	publisher	publisher	NOUN
bibechana-21109	1	64	:	:	PUNCT
bibechana-21109	1	65	research	research	PROPN
bibechana-21109	1	66	council	council	PROPN
bibechana-21109	1	67	of	of	ADP
bibechana-21109	1	68	science	science	NOUN
bibechana-21109	1	69	and	and	CCONJ
bibechana-21109	1	70	technology	technology	NOUN
bibechana-21109	1	71	,	,	PUNCT
bibechana-21109	1	72	biratnagar	biratnagar	NOUN
bibechana-21109	1	73	,	,	PUNCT
bibechana-21109	1	74	nepal	nepal	ADJ
bibechana-21109	1	75	molecular	molecular	ADJ
bibechana-21109	1	76	dynamics	dynamic	NOUN
bibechana-21109	1	77	approach	approach	NOUN
bibechana-21109	1	78	to	to	ADP
bibechana-21109	1	79	the	the	DET
bibechana-21109	1	80	i431v	i431v	PROPN
bibechana-21109	1	81	mutational	mutational	ADJ
bibechana-21109	1	82	impact	impact	NOUN
bibechana-21109	1	83	on	on	ADP
bibechana-21109	1	84	thyroid	thyroid	NOUN
bibechana-21109	1	85	hormone	hormone	NOUN
bibechana-21109	1	86	receptor	receptor	NOUN
bibechana-21109	1	87	-	-	PUNCT
bibechana-21109	1	88	beta	beta	NOUN
bibechana-21109	1	89	tika	tika	X
bibechana-21109	1	90	ram	ram	PROPN
bibechana-21109	1	91	lamichhane1	lamichhane1	PROPN
bibechana-21109	1	92	,	,	PUNCT
bibechana-21109	1	93	sharma	sharma	PROPN
bibechana-21109	1	94	paudel2	paudel2	PROPN
bibechana-21109	1	95	,	,	PUNCT
bibechana-21109	1	96	binod	binod	PROPN
bibechana-21109	1	97	kumar	kumar	PROPN
bibechana-21109	1	98	yadav2	yadav2	PROPN
bibechana-21109	1	99	,	,	PUNCT
bibechana-21109	1	100	hari	hari	PROPN
bibechana-21109	1	101	prasad	prasad	PROPN
bibechana-21109	2	1	lamichhane1	lamichhane1	PROPN
bibechana-21109	2	2	*	*	PROPN
bibechana-21109	2	3	1central	1central	NUM
bibechana-21109	2	4	department	department	PROPN
bibechana-21109	2	5	of	of	ADP
bibechana-21109	2	6	physics	physics	PROPN
bibechana-21109	2	7	,	,	PUNCT
bibechana-21109	2	8	tribhuvan	tribhuvan	PROPN
bibechana-21109	2	9	university	university	PROPN
bibechana-21109	2	10	,	,	PUNCT
bibechana-21109	2	11	kirtipur	kirtipur	NOUN
bibechana-21109	2	12	,	,	PUNCT
bibechana-21109	2	13	kathmandu	kathmandu	NOUN
bibechana-21109	2	14	,	,	PUNCT
bibechana-21109	2	15	nepal	nepal	NOUN
bibechana-21109	2	16	2institute	2institute	NUM
bibechana-21109	2	17	of	of	ADP
bibechana-21109	2	18	medicine	medicine	NOUN
bibechana-21109	2	19	,	,	PUNCT
bibechana-21109	2	20	tribhuvan	tribhuvan	PROPN
bibechana-21109	2	21	university	university	NOUN
bibechana-21109	2	22	,	,	PUNCT
bibechana-21109	2	23	teaching	teach	VERB
bibechana-21109	2	24	hospital	hospital	NOUN
bibechana-21109	2	25	,	,	PUNCT
bibechana-21109	2	26	maharajgunj	maharajgunj	ADJ
bibechana-21109	2	27	,	,	PUNCT
bibechana-21109	2	28	kathmandu	kathmandu	NOUN
bibechana-21109	2	29	,	,	PUNCT
bibechana-21109	2	30	nepal	nepal	NOUN
bibechana-21109	2	31	*	*	NOUN
bibechana-21109	2	32	email	email	NOUN
bibechana-21109	2	33	:	:	PUNCT
bibechana-21109	2	34	hlamichhane1@gmail.com	hlamichhane1@gmail.com	X
bibechana-21109	2	35	article	article	NOUN
bibechana-21109	2	36	history	history	NOUN
bibechana-21109	2	37	:	:	PUNCT
bibechana-21109	2	38	received	receive	VERB
bibechana-21109	2	39	15	15	NUM
bibechana-21109	2	40	march	march	NOUN
bibechana-21109	2	41	,	,	PUNCT
bibechana-21109	2	42	2018	2018	NUM
bibechana-21109	2	43	;	;	PUNCT
bibechana-21109	2	44	accepted	accept	VERB
bibechana-21109	2	45	16	16	NUM
bibechana-21109	2	46	september	september	PROPN
bibechana-21109	2	47	,	,	PUNCT
bibechana-21109	2	48	2018	2018	NUM
bibechana-21109	2	49	doi	doi	NOUN
bibechana-21109	2	50	:	:	PUNCT
bibechana-21109	2	51	http://dx.doi.org/10.3126/bibechana.v13i0.21109	http://dx.doi.org/10.3126/bibechana.v13i0.21109	NUM
bibechana-21109	2	52	this	this	DET
bibechana-21109	2	53	work	work	NOUN
bibechana-21109	2	54	is	be	AUX
bibechana-21109	2	55	licensed	license	VERB
bibechana-21109	2	56	under	under	ADP
bibechana-21109	2	57	the	the	DET
bibechana-21109	2	58	creative	creative	ADJ
bibechana-21109	2	59	commons	common	NOUN
bibechana-21109	2	60	cc	cc	ADP
bibechana-21109	2	61	by	by	ADP
bibechana-21109	2	62	-	-	PUNCT
bibechana-21109	2	63	nc	nc	NOUN
bibechana-21109	2	64	license	license	NOUN
bibechana-21109	2	65	.	.	PUNCT
bibechana-21109	3	1	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	DET
bibechana-21109	3	2	abstract	abstract	ADJ
bibechana-21109	3	3	the	the	DET
bibechana-21109	3	4	point	point	NOUN
bibechana-21109	3	5	mutations	mutation	NOUN
bibechana-21109	3	6	like	like	ADP
bibechana-21109	3	7	i431v	i431v	PROPN
bibechana-21109	3	8	on	on	ADP
bibechana-21109	3	9	thyroid	thyroid	NOUN
bibechana-21109	3	10	hormone	hormone	NOUN
bibechana-21109	3	11	receptor	receptor	NOUN
bibechana-21109	3	12	-	-	PUNCT
bibechana-21109	3	13	beta	beta	NOUN
bibechana-21109	3	14	(	(	PUNCT
bibechana-21109	3	15	thr	thr	NOUN
bibechana-21109	3	16	-	-	PUNCT
bibechana-21109	3	17	β	β	NOUN
bibechana-21109	3	18	)	)	PUNCT
bibechana-21109	3	19	gene	gene	NOUN
bibechana-21109	3	20	cause	cause	VERB
bibechana-21109	3	21	resistance	resistance	NOUN
bibechana-21109	3	22	to	to	PART
bibechana-21109	3	23	thyroid	thyroid	VERB
bibechana-21109	3	24	hormones	hormone	NOUN
bibechana-21109	3	25	(	(	PUNCT
bibechana-21109	3	26	rth	rth	NOUN
bibechana-21109	3	27	)	)	PUNCT
bibechana-21109	3	28	with	with	ADP
bibechana-21109	3	29	the	the	DET
bibechana-21109	3	30	clinical	clinical	ADJ
bibechana-21109	3	31	diagnosis	diagnosis	NOUN
bibechana-21109	3	32	of	of	ADP
bibechana-21109	3	33	elevated	elevated	ADJ
bibechana-21109	3	34	free	free	ADJ
bibechana-21109	3	35	triiodothyronine	triiodothyronine	NOUN
bibechana-21109	3	36	(	(	PUNCT
bibechana-21109	3	37	t3	t3	PROPN
bibechana-21109	3	38	)	)	PUNCT
bibechana-21109	3	39	and	and	CCONJ
bibechana-21109	3	40	free	free	ADJ
bibechana-21109	3	41	thyroxin	thyroxin	NOUN
bibechana-21109	3	42	(	(	PUNCT
bibechana-21109	3	43	t4	t4	PROPN
bibechana-21109	3	44	)	)	PUNCT
bibechana-21109	3	45	but	but	CCONJ
bibechana-21109	3	46	not	not	PART
bibechana-21109	3	47	suppressed	suppress	VERB
bibechana-21109	3	48	thyroid	thyroid	NOUN
bibechana-21109	3	49	stimulating	stimulate	VERB
bibechana-21109	3	50	hormone	hormone	NOUN
bibechana-21109	3	51	(	(	PUNCT
bibechana-21109	3	52	tsh	tsh	NOUN
bibechana-21109	3	53	)	)	PUNCT
bibechana-21109	3	54	on	on	ADP
bibechana-21109	3	55	the	the	DET
bibechana-21109	3	56	blood	blood	NOUN
bibechana-21109	3	57	serum	serum	NOUN
bibechana-21109	3	58	.	.	PUNCT
bibechana-21109	4	1	some	some	DET
bibechana-21109	4	2	ultrasonographic	ultrasonographic	NOUN
bibechana-21109	4	3	(	(	PUNCT
bibechana-21109	4	4	usg	usg	PROPN
bibechana-21109	4	5	)	)	PUNCT
bibechana-21109	4	6	reports	report	NOUN
bibechana-21109	4	7	of	of	ADP
bibechana-21109	4	8	the	the	DET
bibechana-21109	4	9	patients	patient	NOUN
bibechana-21109	4	10	with	with	ADP
bibechana-21109	4	11	rth	rth	PROPN
bibechana-21109	4	12	show	show	PROPN
bibechana-21109	4	13	thyroid	thyroid	NOUN
bibechana-21109	4	14	gland	gland	NOUN
bibechana-21109	4	15	disorder	disorder	NOUN
bibechana-21109	4	16	with	with	ADP
bibechana-21109	4	17	goiter	goiter	NOUN
bibechana-21109	4	18	or	or	CCONJ
bibechana-21109	4	19	nodule(s	nodule(s	NOUN
bibechana-21109	4	20	)	)	PUNCT
bibechana-21109	4	21	or	or	CCONJ
bibechana-21109	4	22	cyst(s	cyst(s	PROPN
bibechana-21109	4	23	)	)	PUNCT
bibechana-21109	4	24	and	and	CCONJ
bibechana-21109	4	25	some	some	DET
bibechana-21109	4	26	usg	usg	PROPN
bibechana-21109	4	27	reports	report	VERB
bibechana-21109	4	28	even	even	ADV
bibechana-21109	4	29	with	with	ADP
bibechana-21109	4	30	rth	rth	NOUN
bibechana-21109	4	31	are	be	AUX
bibechana-21109	4	32	normal	normal	ADJ
bibechana-21109	4	33	.	.	PUNCT
bibechana-21109	5	1	i431v	i431v	PROPN
bibechana-21109	5	2	-	-	PUNCT
bibechana-21109	5	3	mutant	mutant	NOUN
bibechana-21109	5	4	causes	cause	VERB
bibechana-21109	5	5	more	more	ADV
bibechana-21109	5	6	steric	steric	ADJ
bibechana-21109	5	7	hindrance	hindrance	NOUN
bibechana-21109	5	8	while	while	SCONJ
bibechana-21109	5	9	binding	bind	VERB
bibechana-21109	5	10	t3	t3	NOUN
bibechana-21109	5	11	into	into	ADP
bibechana-21109	5	12	thr	thr	PROPN
bibechana-21109	5	13	-	-	PUNCT
bibechana-21109	5	14	β	β	PROPN
bibechana-21109	5	15	than	than	ADP
bibechana-21109	5	16	the	the	DET
bibechana-21109	5	17	native	native	ADJ
bibechana-21109	5	18	wild	wild	ADJ
bibechana-21109	5	19	type	type	NOUN
bibechana-21109	5	20	thrt3	thrt3	PROPN
bibechana-21109	5	21	.	.	PUNCT
bibechana-21109	6	1	the	the	DET
bibechana-21109	6	2	residue	residue	NOUN
bibechana-21109	6	3	on	on	ADP
bibechana-21109	6	4	the	the	DET
bibechana-21109	6	5	431	431	NUM
bibechana-21109	6	6	-	-	PUNCT
bibechana-21109	6	7	codon	codon	NOUN
bibechana-21109	6	8	is	be	AUX
bibechana-21109	6	9	dynamic	dynamic	ADJ
bibechana-21109	6	10	in	in	ADP
bibechana-21109	6	11	nature	nature	NOUN
bibechana-21109	6	12	showing	show	VERB
bibechana-21109	6	13	its	its	PRON
bibechana-21109	6	14	flexibility	flexibility	NOUN
bibechana-21109	6	15	over	over	ADP
bibechana-21109	6	16	the	the	DET
bibechana-21109	6	17	course	course	NOUN
bibechana-21109	6	18	of	of	ADP
bibechana-21109	6	19	entry	entry	NOUN
bibechana-21109	6	20	and	and	CCONJ
bibechana-21109	6	21	release	release	NOUN
bibechana-21109	6	22	of	of	ADP
bibechana-21109	6	23	t3	t3	NOUN
bibechana-21109	6	24	-	-	PUNCT
bibechana-21109	6	25	hormone	hormone	NOUN
bibechana-21109	6	26	into	into	ADP
bibechana-21109	6	27	/	/	SYM
bibechana-21109	6	28	from	from	ADP
bibechana-21109	6	29	the	the	DET
bibechana-21109	6	30	ligand	ligand	ADJ
bibechana-21109	6	31	binding	bind	VERB
bibechana-21109	6	32	pocket	pocket	NOUN
bibechana-21109	6	33	.	.	PUNCT
bibechana-21109	7	1	the	the	DET
bibechana-21109	7	2	more	more	ADV
bibechana-21109	7	3	increased	increase	VERB
bibechana-21109	7	4	solvent	solvent	ADJ
bibechana-21109	7	5	accessible	accessible	ADJ
bibechana-21109	7	6	surface	surface	NOUN
bibechana-21109	7	7	area	area	NOUN
bibechana-21109	7	8	of	of	ADP
bibechana-21109	7	9	i431v	i431v	PROPN
bibechana-21109	7	10	-	-	PUNCT
bibechana-21109	7	11	mutant	mutant	NOUN
bibechana-21109	7	12	than	than	ADP
bibechana-21109	7	13	that	that	PRON
bibechana-21109	7	14	of	of	ADP
bibechana-21109	7	15	native	native	ADJ
bibechana-21109	7	16	i431	i431	PROPN
bibechana-21109	7	17	-	-	PUNCT
bibechana-21109	7	18	residue	residue	NOUN
bibechana-21109	7	19	makes	make	VERB
bibechana-21109	7	20	the	the	DET
bibechana-21109	7	21	partial	partial	ADJ
bibechana-21109	7	22	unfolding	unfolding	NOUN
bibechana-21109	7	23	of	of	ADP
bibechana-21109	7	24	the	the	DET
bibechana-21109	7	25	globular	globular	ADJ
bibechana-21109	7	26	thr	thr	PROPN
bibechana-21109	7	27	-	-	PUNCT
bibechana-21109	7	28	β	β	X
bibechana-21109	7	29	protein	protein	NOUN
bibechana-21109	7	30	.	.	PUNCT
bibechana-21109	8	1	the	the	DET
bibechana-21109	8	2	smaller	small	ADJ
bibechana-21109	8	3	height	height	NOUN
bibechana-21109	8	4	of	of	ADP
bibechana-21109	8	5	radial	radial	ADJ
bibechana-21109	8	6	distribution	distribution	NOUN
bibechana-21109	8	7	function	function	NOUN
bibechana-21109	8	8	between	between	ADP
bibechana-21109	8	9	i431	i431	PROPN
bibechana-21109	8	10	-	-	PUNCT
bibechana-21109	8	11	mutant	mutant	NOUN
bibechana-21109	8	12	and	and	CCONJ
bibechana-21109	8	13	t3	t3	PROPN
bibechana-21109	8	14	shows	show	VERB
bibechana-21109	8	15	the	the	DET
bibechana-21109	8	16	decrease	decrease	NOUN
bibechana-21109	8	17	in	in	ADP
bibechana-21109	8	18	probability	probability	NOUN
bibechana-21109	8	19	of	of	ADP
bibechana-21109	8	20	finding	find	VERB
bibechana-21109	8	21	the	the	DET
bibechana-21109	8	22	atomic	atomic	ADJ
bibechana-21109	8	23	particles	particle	NOUN
bibechana-21109	8	24	nearby	nearby	ADV
bibechana-21109	8	25	t3	t3	NOUN
bibechana-21109	8	26	-	-	PUNCT
bibechana-21109	8	27	hormone	hormone	NOUN
bibechana-21109	8	28	in	in	ADP
bibechana-21109	8	29	thrt3	thrt3	PROPN
bibechana-21109	8	30	-	-	PUNCT
bibechana-21109	8	31	mt	mt	PROPN
bibechana-21109	8	32	than	than	ADP
bibechana-21109	8	33	in	in	ADP
bibechana-21109	8	34	thrt3	thrt3	PROPN
bibechana-21109	8	35	-	-	PUNCT
bibechana-21109	8	36	wt	wt	NOUN
bibechana-21109	8	37	.	.	PUNCT
bibechana-21109	9	1	the	the	DET
bibechana-21109	9	2	electrostatic	electrostatic	ADJ
bibechana-21109	9	3	interaction	interaction	NOUN
bibechana-21109	9	4	energy	energy	NOUN
bibechana-21109	9	5	between	between	ADP
bibechana-21109	9	6	native	native	ADJ
bibechana-21109	9	7	i431	i431	PROPN
bibechana-21109	9	8	and	and	CCONJ
bibechana-21109	9	9	t3	t3	PROPN
bibechana-21109	9	10	is	be	AUX
bibechana-21109	9	11	negative	negative	ADJ
bibechana-21109	9	12	,	,	PUNCT
bibechana-21109	9	13	but	but	CCONJ
bibechana-21109	9	14	it	it	PRON
bibechana-21109	9	15	is	be	AUX
bibechana-21109	9	16	positive	positive	ADJ
bibechana-21109	9	17	between	between	ADP
bibechana-21109	9	18	i431v	i431v	PROPN
bibechana-21109	9	19	and	and	CCONJ
bibechana-21109	9	20	t3	t3	PROPN
bibechana-21109	9	21	.	.	PUNCT
bibechana-21109	10	1	moreover	moreover	ADV
bibechana-21109	10	2	,	,	PUNCT
bibechana-21109	10	3	the	the	DET
bibechana-21109	10	4	internal	internal	ADJ
bibechana-21109	10	5	energy	energy	NOUN
bibechana-21109	10	6	of	of	ADP
bibechana-21109	10	7	i431v	i431v	PROPN
bibechana-21109	10	8	-	-	PUNCT
bibechana-21109	10	9	mutant	mutant	NOUN
bibechana-21109	10	10	has	have	AUX
bibechana-21109	10	11	been	be	AUX
bibechana-21109	10	12	found	find	VERB
bibechana-21109	10	13	smaller	small	ADJ
bibechana-21109	10	14	than	than	ADP
bibechana-21109	10	15	that	that	PRON
bibechana-21109	10	16	of	of	ADP
bibechana-21109	10	17	native	native	ADJ
bibechana-21109	10	18	i431	i431	PROPN
bibechana-21109	10	19	-	-	PUNCT
bibechana-21109	10	20	residue	residue	NOUN
bibechana-21109	10	21	in	in	ADP
bibechana-21109	10	22	thrt3	thrt3	PROPN
bibechana-21109	10	23	systems	system	NOUN
bibechana-21109	10	24	.	.	PUNCT
bibechana-21109	11	1	keywords	keyword	NOUN
bibechana-21109	11	2	:	:	PUNCT
bibechana-21109	11	3	thyroid	thyroid	VERB
bibechana-21109	11	4	hormone	hormone	NOUN
bibechana-21109	11	5	receptor	receptor	NOUN
bibechana-21109	11	6	;	;	PUNCT
bibechana-21109	11	7	resistance	resistance	NOUN
bibechana-21109	11	8	to	to	PART
bibechana-21109	11	9	thyroid	thyroid	NOUN
bibechana-21109	11	10	hormones	hormone	NOUN
bibechana-21109	11	11	;	;	PUNCT
bibechana-21109	11	12	point	point	NOUN
bibechana-21109	11	13	mutation	mutation	NOUN
bibechana-21109	11	14	;	;	PUNCT
bibechana-21109	11	15	interaction	interaction	NOUN
bibechana-21109	11	16	energy	energy	NOUN
bibechana-21109	11	17	;	;	PUNCT
bibechana-21109	11	18	internal	internal	ADJ
bibechana-21109	11	19	energy	energy	NOUN
bibechana-21109	11	20	.	.	PUNCT
bibechana-21109	12	1	1	1	X
bibechana-21109	12	2	.	.	X
bibechana-21109	12	3	introduction	introduction	NOUN
bibechana-21109	12	4	thyroid	thyroid	NOUN
bibechana-21109	12	5	hormone	hormone	NOUN
bibechana-21109	12	6	receptors	receptor	NOUN
bibechana-21109	12	7	(	(	PUNCT
bibechana-21109	12	8	thrs	thrs	NOUN
bibechana-21109	12	9	)	)	PUNCT
bibechana-21109	12	10	are	be	AUX
bibechana-21109	12	11	the	the	DET
bibechana-21109	12	12	nuclear	nuclear	ADJ
bibechana-21109	12	13	receptor	receptor	NOUN
bibechana-21109	12	14	proteins	protein	NOUN
bibechana-21109	12	15	that	that	PRON
bibechana-21109	12	16	actively	actively	ADV
bibechana-21109	12	17	bind	bind	VERB
bibechana-21109	12	18	triiodothyronine	triiodothyronine	NOUN
bibechana-21109	12	19	(	(	PUNCT
bibechana-21109	12	20	t3	t3	NOUN
bibechana-21109	12	21	:	:	PUNCT
bibechana-21109	12	22	hormone	hormone	NOUN
bibechana-21109	12	23	secreted	secrete	VERB
bibechana-21109	12	24	by	by	ADP
bibechana-21109	12	25	thyroid	thyroid	NOUN
bibechana-21109	12	26	gland	gland	NOUN
bibechana-21109	12	27	)	)	PUNCT
bibechana-21109	12	28	to	to	PART
bibechana-21109	12	29	mediate	mediate	VERB
bibechana-21109	12	30	the	the	DET
bibechana-21109	12	31	biological	biological	ADJ
bibechana-21109	12	32	activities	activity	NOUN
bibechana-21109	12	33	associated	associate	VERB
bibechana-21109	12	34	with	with	ADP
bibechana-21109	12	35	gene	gene	NOUN
bibechana-21109	12	36	transcription	transcription	NOUN
bibechana-21109	12	37	.	.	PUNCT
bibechana-21109	13	1	thrs	thrs	ADJ
bibechana-21109	13	2	regulate	regulate	VERB
bibechana-21109	13	3	gene	gene	NOUN
bibechana-21109	13	4	expressions	expression	NOUN
bibechana-21109	13	5	upon	upon	SCONJ
bibechana-21109	13	6	binding	bind	VERB
bibechana-21109	13	7	to	to	ADP
bibechana-21109	13	8	the	the	DET
bibechana-21109	13	9	dna	dna	PROPN
bibechana-21109	13	10	sequences	sequence	NOUN
bibechana-21109	13	11	called	call	VERB
bibechana-21109	13	12	as	as	ADP
bibechana-21109	13	13	thyroid	thyroid	NOUN
bibechana-21109	13	14	response	response	NOUN
bibechana-21109	13	15	elements	element	NOUN
bibechana-21109	13	16	(	(	PUNCT
bibechana-21109	13	17	tres	tre	NOUN
bibechana-21109	13	18	)	)	PUNCT
bibechana-21109	13	19	.	.	PUNCT
bibechana-21109	14	1	thrs	thrs	PROPN
bibechana-21109	14	2	have	have	VERB
bibechana-21109	14	3	two	two	NUM
bibechana-21109	14	4	isoforms	isoform	NOUN
bibechana-21109	14	5	thr	thr	PROPN
bibechana-21109	14	6	-	-	PUNCT
bibechana-21109	14	7	α	α	NOUN
bibechana-21109	14	8	and	and	CCONJ
bibechana-21109	14	9	thr	thr	PROPN
bibechana-21109	14	10	-	-	PUNCT
bibechana-21109	14	11	β	β	PROPN
bibechana-21109	14	12	that	that	PRON
bibechana-21109	14	13	are	be	AUX
bibechana-21109	14	14	in	in	ADP
bibechana-21109	14	15	hetero	hetero	NOUN
bibechana-21109	14	16	-	-	PUNCT
bibechana-21109	14	17	diversity	diversity	NOUN
bibechana-21109	14	18	in	in	ADP
bibechana-21109	14	19	the	the	DET
bibechana-21109	14	20	different	different	ADJ
bibechana-21109	14	21	organs	organ	NOUN
bibechana-21109	14	22	.	.	PUNCT
bibechana-21109	15	1	t3	t3	PROPN
bibechana-21109	15	2	has	have	VERB
bibechana-21109	15	3	the	the	DET
bibechana-21109	15	4	higher	high	ADJ
bibechana-21109	15	5	affinity	affinity	NOUN
bibechana-21109	15	6	to	to	PART
bibechana-21109	15	7	bind	bind	VERB
bibechana-21109	15	8	into	into	ADP
bibechana-21109	15	9	both	both	DET
bibechana-21109	15	10	isoforms	isoform	NOUN
bibechana-21109	15	11	than	than	ADP
bibechana-21109	15	12	thyroxin	thyroxin	NOUN
bibechana-21109	15	13	(	(	PUNCT
bibechana-21109	15	14	t4	t4	PROPN
bibechana-21109	15	15	)	)	PUNCT
bibechana-21109	15	16	.	.	PUNCT
bibechana-21109	16	1	while	while	SCONJ
bibechana-21109	16	2	t3	t3	PROPN
bibechana-21109	16	3	tika	tika	X
bibechana-21109	16	4	ram	ram	PROPN
bibechana-21109	16	5	lamichhane	lamichhane	NOUN
bibechana-21109	16	6	et	et	PROPN
bibechana-21109	16	7	al./	al./	ADV
bibechana-21109	16	8	bibechana	bibechana	PROPN
bibechana-21109	16	9	16	16	NUM
bibechana-21109	16	10	(	(	PUNCT
bibechana-21109	16	11	2019	2019	NUM
bibechana-21109	16	12	)	)	PUNCT
bibechana-21109	16	13	79	79	NUM
bibechana-21109	16	14	-	-	SYM
bibechana-21109	16	15	91	91	NUM
bibechana-21109	16	16	:	:	PUNCT
bibechana-21109	16	17	rcost	rcost	NOUN
bibechana-21109	16	18	p.80	p.80	PROPN
bibechana-21109	16	19	(	(	PUNCT
bibechana-21109	16	20	online	online	ADJ
bibechana-21109	16	21	publication	publication	NOUN
bibechana-21109	16	22	:	:	PUNCT
bibechana-21109	16	23	dec	dec	PROPN
bibechana-21109	16	24	.	.	PROPN
bibechana-21109	16	25	,	,	PUNCT
bibechana-21109	16	26	2018	2018	NUM
bibechana-21109	16	27	)	)	PUNCT
bibechana-21109	16	28	binds	bind	VERB
bibechana-21109	16	29	to	to	ADP
bibechana-21109	16	30	the	the	DET
bibechana-21109	16	31	ligand	ligand	ADJ
bibechana-21109	16	32	binding	bind	VERB
bibechana-21109	16	33	domain	domain	NOUN
bibechana-21109	16	34	(	(	PUNCT
bibechana-21109	16	35	lbd	lbd	PROPN
bibechana-21109	16	36	)	)	PUNCT
bibechana-21109	16	37	of	of	ADP
bibechana-21109	16	38	hydrophobicity	hydrophobicity	NOUN
bibechana-21109	16	39	,	,	PUNCT
bibechana-21109	16	40	thr	thr	PROPN
bibechana-21109	16	41	shows	show	VERB
bibechana-21109	16	42	its	its	PRON
bibechana-21109	16	43	structural	structural	ADJ
bibechana-21109	16	44	change	change	NOUN
bibechana-21109	16	45	[	[	X
bibechana-21109	16	46	1	1	NUM
bibechana-21109	16	47	-	-	SYM
bibechana-21109	16	48	4	4	NUM
bibechana-21109	16	49	]	]	PUNCT
bibechana-21109	16	50	.	.	PUNCT
bibechana-21109	17	1	the	the	DET
bibechana-21109	17	2	carboxy	carboxy	ADJ
bibechana-21109	17	3	-	-	PUNCT
bibechana-21109	17	4	terminal	terminal	ADJ
bibechana-21109	17	5	activation	activation	NOUN
bibechana-21109	17	6	domain	domain	NOUN
bibechana-21109	17	7	forms	form	VERB
bibechana-21109	17	8	an	an	DET
bibechana-21109	17	9	amphi	amphi	ADJ
bibechana-21109	17	10	-	-	PUNCT
bibechana-21109	17	11	pathic	pathic	ADJ
bibechana-21109	17	12	helix[2	helix[2	NOUN
bibechana-21109	17	13	,	,	PUNCT
bibechana-21109	17	14	3	3	NUM
bibechana-21109	17	15	]	]	PUNCT
bibechana-21109	17	16	as	as	ADP
bibechana-21109	17	17	a	a	DET
bibechana-21109	17	18	part	part	NOUN
bibechana-21109	17	19	of	of	ADP
bibechana-21109	17	20	cavity	cavity	NOUN
bibechana-21109	17	21	or	or	CCONJ
bibechana-21109	17	22	lbd	lbd	PROPN
bibechana-21109	17	23	.	.	PUNCT
bibechana-21109	18	1	the	the	DET
bibechana-21109	18	2	dynamic	dynamic	ADJ
bibechana-21109	18	3	nature	nature	NOUN
bibechana-21109	18	4	of	of	ADP
bibechana-21109	18	5	helix-12	helix-12	PROPN
bibechana-21109	18	6	(	(	PUNCT
bibechana-21109	18	7	h12	h12	NOUN
bibechana-21109	18	8	in	in	ADP
bibechana-21109	18	9	fig	fig	NOUN
bibechana-21109	18	10	.	.	PUNCT
bibechana-21109	19	1	2	2	NUM
bibechana-21109	19	2	-	-	SYM
bibechana-21109	19	3	c	c	NOUN
bibechana-21109	19	4	)	)	PUNCT
bibechana-21109	19	5	of	of	ADP
bibechana-21109	19	6	thr	thr	PROPN
bibechana-21109	19	7	is	be	AUX
bibechana-21109	19	8	is	be	AUX
bibechana-21109	19	9	important	important	ADJ
bibechana-21109	19	10	for	for	ADP
bibechana-21109	19	11	the	the	DET
bibechana-21109	19	12	hormone	hormone	NOUN
bibechana-21109	19	13	binding	bind	VERB
bibechana-21109	19	14	,	,	PUNCT
bibechana-21109	19	15	ligand	ligand	NOUN
bibechana-21109	19	16	dissociation	dissociation	NOUN
bibechana-21109	19	17	,	,	PUNCT
bibechana-21109	19	18	activation	activation	NOUN
bibechana-21109	19	19	mechanism	mechanism	NOUN
bibechana-21109	19	20	and	and	CCONJ
bibechana-21109	19	21	regulation	regulation	NOUN
bibechana-21109	19	22	of	of	ADP
bibechana-21109	19	23	transcription	transcription	NOUN
bibechana-21109	19	24	activity	activity	NOUN
bibechana-21109	20	1	[	[	X
bibechana-21109	20	2	5	5	NUM
bibechana-21109	20	3	]	]	PUNCT
bibechana-21109	20	4	.	.	PUNCT
bibechana-21109	21	1	the	the	DET
bibechana-21109	21	2	mutational	mutational	ADJ
bibechana-21109	21	3	impact	impact	NOUN
bibechana-21109	21	4	on	on	ADP
bibechana-21109	21	5	thr	thr	PROPN
bibechana-21109	21	6	reduces	reduce	VERB
bibechana-21109	21	7	the	the	DET
bibechana-21109	21	8	hormone	hormone	NOUN
bibechana-21109	21	9	binding	bind	VERB
bibechana-21109	21	10	affinity	affinity	NOUN
bibechana-21109	21	11	and	and	CCONJ
bibechana-21109	21	12	gene	gene	NOUN
bibechana-21109	21	13	expression	expression	NOUN
bibechana-21109	21	14	activity	activity	NOUN
bibechana-21109	21	15	.	.	PUNCT
bibechana-21109	22	1	ultimately	ultimately	ADV
bibechana-21109	22	2	,	,	PUNCT
bibechana-21109	22	3	the	the	DET
bibechana-21109	22	4	mutations	mutation	NOUN
bibechana-21109	22	5	leading	lead	VERB
bibechana-21109	22	6	to	to	ADP
bibechana-21109	22	7	the	the	DET
bibechana-21109	22	8	resistance	resistance	NOUN
bibechana-21109	22	9	to	to	PART
bibechana-21109	22	10	thyroid	thyroid	VERB
bibechana-21109	22	11	hormone	hormone	NOUN
bibechana-21109	22	12	(	(	PUNCT
bibechana-21109	22	13	rth	rth	NOUN
bibechana-21109	22	14	)	)	PUNCT
bibechana-21109	22	15	cause	cause	VERB
bibechana-21109	22	16	the	the	DET
bibechana-21109	22	17	endocrine	endocrine	NOUN
bibechana-21109	22	18	disorder	disorder	NOUN
bibechana-21109	22	19	.	.	PUNCT
bibechana-21109	23	1	the	the	DET
bibechana-21109	23	2	inactivated	inactivated	ADJ
bibechana-21109	23	3	thr	thr	PROPN
bibechana-21109	23	4	-	-	PUNCT
bibechana-21109	23	5	β	β	NOUN
bibechana-21109	23	6	gene	gene	NOUN
bibechana-21109	23	7	by	by	ADP
bibechana-21109	23	8	means	mean	NOUN
bibechana-21109	23	9	of	of	ADP
bibechana-21109	23	10	homozygous	homozygous	ADJ
bibechana-21109	23	11	mutant	mutant	NOUN
bibechana-21109	23	12	(	(	PUNCT
bibechana-21109	23	13	thrb-/-	thrb-/-	NOUN
bibechana-21109	23	14	)	)	PUNCT
bibechana-21109	23	15	in	in	ADP
bibechana-21109	23	16	mice	mice	NOUN
bibechana-21109	23	17	results	result	NOUN
bibechana-21109	23	18	in	in	ADP
bibechana-21109	23	19	a	a	DET
bibechana-21109	23	20	goiter	goiter	NOUN
bibechana-21109	23	21	and	and	CCONJ
bibechana-21109	23	22	elevated	elevated	ADJ
bibechana-21109	23	23	levels	level	NOUN
bibechana-21109	23	24	of	of	ADP
bibechana-21109	23	25	thyroid	thyroid	NOUN
bibechana-21109	23	26	hormones	hormone	NOUN
bibechana-21109	23	27	[	[	X
bibechana-21109	23	28	6	6	NUM
bibechana-21109	23	29	]	]	PUNCT
bibechana-21109	23	30	.	.	PUNCT
bibechana-21109	24	1	the	the	DET
bibechana-21109	24	2	mutant	mutant	ADJ
bibechana-21109	24	3	t327i	t327i	NUM
bibechana-21109	24	4	found	find	VERB
bibechana-21109	24	5	in	in	ADP
bibechana-21109	24	6	thr	thr	PROPN
bibechana-21109	24	7	-	-	PUNCT
bibechana-21109	24	8	β	β	PROPN
bibechana-21109	24	9	gene	gene	NOUN
bibechana-21109	24	10	shows	show	VERB
bibechana-21109	24	11	the	the	DET
bibechana-21109	24	12	paucity	paucity	NOUN
bibechana-21109	24	13	of	of	ADP
bibechana-21109	24	14	symptoms	symptom	NOUN
bibechana-21109	24	15	and	and	CCONJ
bibechana-21109	24	16	signs	sign	NOUN
bibechana-21109	24	17	of	of	ADP
bibechana-21109	24	18	thyroid	thyroid	NOUN
bibechana-21109	24	19	dysfunction	dysfunction	NOUN
bibechana-21109	24	20	suggesting	suggest	VERB
bibechana-21109	24	21	rth	rth	PROPN
bibechana-21109	24	22	despite	despite	SCONJ
bibechana-21109	24	23	the	the	DET
bibechana-21109	24	24	increased	increase	VERB
bibechana-21109	24	25	serum	serum	NOUN
bibechana-21109	24	26	levels	level	NOUN
bibechana-21109	24	27	of	of	ADP
bibechana-21109	24	28	t3	t3	PROPN
bibechana-21109	24	29	,	,	PUNCT
bibechana-21109	24	30	t4	t4	PROPN
bibechana-21109	24	31	and	and	CCONJ
bibechana-21109	24	32	thyroid	thyroid	VERB
bibechana-21109	24	33	stimulating	stimulate	VERB
bibechana-21109	24	34	hormone	hormone	NOUN
bibechana-21109	24	35	(	(	PUNCT
bibechana-21109	24	36	tsh	tsh	NOUN
bibechana-21109	24	37	)	)	PUNCT
bibechana-21109	25	1	[	[	X
bibechana-21109	25	2	7	7	NUM
bibechana-21109	25	3	]	]	PUNCT
bibechana-21109	25	4	.	.	PUNCT
bibechana-21109	26	1	a	a	DET
bibechana-21109	26	2	rare	rare	ADJ
bibechana-21109	26	3	mutation	mutation	NOUN
bibechana-21109	26	4	a268	a268	PROPN
bibechana-21109	26	5	g	g	NOUN
bibechana-21109	26	6	found	find	VERB
bibechana-21109	26	7	in	in	ADP
bibechana-21109	26	8	axon	axon	NOUN
bibechana-21109	26	9	9	9	NUM
bibechana-21109	26	10	of	of	ADP
bibechana-21109	26	11	thr	thr	PROPN
bibechana-21109	26	12	-	-	PUNCT
bibechana-21109	26	13	β	β	NOUN
bibechana-21109	26	14	gene	gene	NOUN
bibechana-21109	26	15	results	result	NOUN
bibechana-21109	26	16	rth	rth	ADJ
bibechana-21109	26	17	with	with	ADP
bibechana-21109	26	18	elevated	elevated	ADJ
bibechana-21109	26	19	serum	serum	NOUN
bibechana-21109	26	20	t3	t3	PROPN
bibechana-21109	26	21	and	and	CCONJ
bibechana-21109	26	22	t4	t4	PROPN
bibechana-21109	26	23	,	,	PUNCT
bibechana-21109	26	24	tsh	tsh	NOUN
bibechana-21109	26	25	in	in	ADP
bibechana-21109	26	26	the	the	DET
bibechana-21109	26	27	normal	normal	ADJ
bibechana-21109	26	28	range	range	NOUN
bibechana-21109	26	29	and	and	CCONJ
bibechana-21109	26	30	the	the	DET
bibechana-21109	26	31	episodic	episodic	ADJ
bibechana-21109	26	32	palpitations	palpitation	NOUN
bibechana-21109	26	33	associated	associate	VERB
bibechana-21109	26	34	with	with	ADP
bibechana-21109	26	35	mild	mild	ADJ
bibechana-21109	26	36	dizziness	dizziness	NOUN
bibechana-21109	26	37	[	[	X
bibechana-21109	26	38	8	8	NUM
bibechana-21109	26	39	]	]	PUNCT
bibechana-21109	26	40	.	.	PUNCT
bibechana-21109	27	1	a	a	DET
bibechana-21109	27	2	heterogeneous	heterogeneous	ADJ
bibechana-21109	27	3	mutation	mutation	NOUN
bibechana-21109	27	4	g344r	g344r	PROPN
bibechana-21109	27	5	is	be	AUX
bibechana-21109	27	6	identified	identify	VERB
bibechana-21109	27	7	in	in	ADP
bibechana-21109	27	8	axon	axon	NOUN
bibechana-21109	27	9	10	10	NUM
bibechana-21109	27	10	of	of	ADP
bibechana-21109	27	11	thr	thr	PROPN
bibechana-21109	27	12	-	-	PUNCT
bibechana-21109	27	13	β	β	NOUN
bibechana-21109	27	14	gene	gene	NOUN
bibechana-21109	27	15	of	of	ADP
bibechana-21109	27	16	10	10	NUM
bibechana-21109	27	17	-	-	PUNCT
bibechana-21109	27	18	month	month	NOUN
bibechana-21109	27	19	-	-	PUNCT
bibechana-21109	27	20	old	old	ADJ
bibechana-21109	27	21	-	-	PUNCT
bibechana-21109	27	22	female	female	NOUN
bibechana-21109	27	23	resulting	result	VERB
bibechana-21109	27	24	in	in	ADP
bibechana-21109	27	25	paucity	paucity	NOUN
bibechana-21109	27	26	of	of	ADP
bibechana-21109	27	27	symptoms	symptom	NOUN
bibechana-21109	27	28	of	of	ADP
bibechana-21109	27	29	rth	rth	NOUN
bibechana-21109	27	30	with	with	ADP
bibechana-21109	27	31	normal	normal	ADJ
bibechana-21109	27	32	t3	t3	PROPN
bibechana-21109	27	33	,	,	PUNCT
bibechana-21109	27	34	t4	t4	PROPN
bibechana-21109	27	35	and	and	CCONJ
bibechana-21109	27	36	tsh	tsh	NOUN
bibechana-21109	27	37	levels	level	NOUN
bibechana-21109	27	38	[	[	X
bibechana-21109	27	39	9	9	NUM
bibechana-21109	27	40	]	]	PUNCT
bibechana-21109	27	41	.	.	PUNCT
bibechana-21109	28	1	also	also	ADV
bibechana-21109	28	2	,	,	PUNCT
bibechana-21109	28	3	r383h	r383h	PROPN
bibechana-21109	28	4	mutation	mutation	NOUN
bibechana-21109	28	5	is	be	AUX
bibechana-21109	28	6	found	find	VERB
bibechana-21109	28	7	in	in	ADP
bibechana-21109	28	8	thr	thr	PROPN
bibechana-21109	28	9	-	-	PUNCT
bibechana-21109	28	10	β	β	NOUN
bibechana-21109	28	11	gene	gene	NOUN
bibechana-21109	28	12	of	of	ADP
bibechana-21109	28	13	a	a	DET
bibechana-21109	28	14	woman	woman	NOUN
bibechana-21109	28	15	with	with	ADP
bibechana-21109	28	16	inappropriate	inappropriate	ADJ
bibechana-21109	28	17	central	central	ADJ
bibechana-21109	28	18	secretion	secretion	NOUN
bibechana-21109	28	19	of	of	ADP
bibechana-21109	28	20	tsh	tsh	NOUN
bibechana-21109	28	21	despite	despite	SCONJ
bibechana-21109	28	22	of	of	ADP
bibechana-21109	28	23	elevated	elevated	ADJ
bibechana-21109	28	24	t3	t3	PROPN
bibechana-21109	28	25	and	and	CCONJ
bibechana-21109	28	26	t4	t4	PROPN
bibechana-21109	29	1	[	[	X
bibechana-21109	29	2	10	10	NUM
bibechana-21109	29	3	]	]	PUNCT
bibechana-21109	29	4	.	.	PUNCT
bibechana-21109	30	1	the	the	DET
bibechana-21109	30	2	rth	rth	PROPN
bibechana-21109	30	3	patients	patient	NOUN
bibechana-21109	30	4	are	be	AUX
bibechana-21109	30	5	clinically	clinically	ADV
bibechana-21109	30	6	euthyroid	euthyroid	NOUN
bibechana-21109	30	7	or	or	CCONJ
bibechana-21109	30	8	hypothyroid	hypothyroid	ADJ
bibechana-21109	30	9	depending	depend	VERB
bibechana-21109	30	10	on	on	ADP
bibechana-21109	30	11	severity	severity	NOUN
bibechana-21109	30	12	of	of	ADP
bibechana-21109	30	13	mutation	mutation	NOUN
bibechana-21109	30	14	.	.	PUNCT
bibechana-21109	31	1	a	a	DET
bibechana-21109	31	2	point	point	NOUN
bibechana-21109	31	3	mutation	mutation	NOUN
bibechana-21109	31	4	r429q	r429q	NOUN
bibechana-21109	31	5	found	find	VERB
bibechana-21109	31	6	in	in	ADP
bibechana-21109	31	7	mice	mouse	NOUN
bibechana-21109	31	8	has	have	VERB
bibechana-21109	31	9	the	the	DET
bibechana-21109	31	10	elevated	elevate	VERB
bibechana-21109	31	11	serum	serum	NOUN
bibechana-21109	31	12	thyroid	thyroid	NOUN
bibechana-21109	31	13	hormones	hormone	NOUN
bibechana-21109	31	14	but	but	CCONJ
bibechana-21109	31	15	the	the	DET
bibechana-21109	31	16	inappropriate	inappropriate	ADJ
bibechana-21109	31	17	tsh	tsh	NOUN
bibechana-21109	31	18	consistent	consistent	ADJ
bibechana-21109	31	19	with	with	ADP
bibechana-21109	31	20	hypothalamic	hypothalamic	ADJ
bibechana-21109	31	21	-	-	PUNCT
bibechana-21109	31	22	pituitary	pituitary	ADJ
bibechana-21109	31	23	rth	rth	NOUN
bibechana-21109	32	1	[	[	X
bibechana-21109	32	2	11	11	NUM
bibechana-21109	32	3	]	]	PUNCT
bibechana-21109	32	4	.	.	PUNCT
bibechana-21109	33	1	the	the	DET
bibechana-21109	33	2	active	active	ADJ
bibechana-21109	33	3	sites	site	NOUN
bibechana-21109	33	4	of	of	ADP
bibechana-21109	33	5	these	these	DET
bibechana-21109	33	6	point	point	NOUN
bibechana-21109	33	7	mutations	mutation	NOUN
bibechana-21109	33	8	along	along	ADP
bibechana-21109	33	9	with	with	ADP
bibechana-21109	33	10	the	the	DET
bibechana-21109	33	11	site	site	NOUN
bibechana-21109	33	12	of	of	ADP
bibechana-21109	33	13	i431v	i431v	PROPN
bibechana-21109	33	14	-	-	PUNCT
bibechana-21109	33	15	mutant	mutant	NOUN
bibechana-21109	33	16	[	[	X
bibechana-21109	33	17	12	12	NUM
bibechana-21109	33	18	]	]	PUNCT
bibechana-21109	33	19	in	in	ADP
bibechana-21109	33	20	the	the	DET
bibechana-21109	33	21	thr	thr	PROPN
bibechana-21109	33	22	-	-	PUNCT
bibechana-21109	33	23	β	β	NOUN
bibechana-21109	33	24	gene	gene	NOUN
bibechana-21109	33	25	are	be	AUX
bibechana-21109	33	26	indicated	indicate	VERB
bibechana-21109	33	27	in	in	ADP
bibechana-21109	33	28	fig	fig	NOUN
bibechana-21109	33	29	.	.	PUNCT
bibechana-21109	34	1	(	(	PUNCT
bibechana-21109	34	2	2	2	NUM
bibechana-21109	34	3	-	-	SYM
bibechana-21109	34	4	c	c	NOUN
bibechana-21109	34	5	)	)	PUNCT
bibechana-21109	34	6	.	.	PUNCT
bibechana-21109	35	1	the	the	DET
bibechana-21109	35	2	helix-12	helix-12	PROPN
bibechana-21109	35	3	serves	serve	VERB
bibechana-21109	35	4	as	as	ADP
bibechana-21109	35	5	a	a	DET
bibechana-21109	35	6	selective	selective	ADJ
bibechana-21109	35	7	gatekeeper	gatekeeper	NOUN
bibechana-21109	35	8	which	which	PRON
bibechana-21109	35	9	is	be	AUX
bibechana-21109	35	10	responsible	responsible	ADJ
bibechana-21109	35	11	for	for	ADP
bibechana-21109	35	12	corepressor	corepressor	NOUN
bibechana-21109	35	13	specificity	specificity	NOUN
bibechana-21109	35	14	by	by	ADP
bibechana-21109	35	15	the	the	DET
bibechana-21109	35	16	wild	wild	ADJ
bibechana-21109	35	17	type	type	NOUN
bibechana-21109	35	18	receptor	receptor	NOUN
bibechana-21109	35	19	(	(	PUNCT
bibechana-21109	35	20	thr	thr	NOUN
bibechana-21109	35	21	-	-	PUNCT
bibechana-21109	35	22	wt	wt	NOUN
bibechana-21109	35	23	)	)	PUNCT
bibechana-21109	35	24	.	.	PUNCT
bibechana-21109	36	1	the	the	DET
bibechana-21109	36	2	point	point	NOUN
bibechana-21109	36	3	mutations	mutation	NOUN
bibechana-21109	36	4	in	in	ADP
bibechana-21109	36	5	thr	thr	PROPN
bibechana-21109	36	6	are	be	AUX
bibechana-21109	36	7	all	all	ADV
bibechana-21109	36	8	positioned	positioned	ADJ
bibechana-21109	36	9	to	to	PART
bibechana-21109	36	10	impact	impact	VERB
bibechana-21109	36	11	the	the	DET
bibechana-21109	36	12	gatekeeper	gatekeeper	NOUN
bibechana-21109	36	13	functions	function	NOUN
bibechana-21109	36	14	and	and	CCONJ
bibechana-21109	36	15	then	then	ADV
bibechana-21109	36	16	to	to	PART
bibechana-21109	36	17	change	change	VERB
bibechana-21109	36	18	corepressor	corepressor	NOUN
bibechana-21109	36	19	specificity	specificity	NOUN
bibechana-21109	36	20	by	by	ADP
bibechana-21109	36	21	the	the	DET
bibechana-21109	36	22	mutated	mutate	VERB
bibechana-21109	36	23	receptor	receptor	NOUN
bibechana-21109	36	24	(	(	PUNCT
bibechana-21109	36	25	thr	thr	PROPN
bibechana-21109	36	26	-	-	PUNCT
bibechana-21109	36	27	mt	mt	PROPN
bibechana-21109	36	28	)	)	PUNCT
bibechana-21109	37	1	[	[	X
bibechana-21109	37	2	13	13	NUM
bibechana-21109	37	3	,	,	PUNCT
bibechana-21109	37	4	14	14	NUM
bibechana-21109	37	5	]	]	PUNCT
bibechana-21109	37	6	.	.	PUNCT
bibechana-21109	38	1	thr	thr	PROPN
bibechana-21109	38	2	-	-	PUNCT
bibechana-21109	38	3	wts	wts	PROPN
bibechana-21109	38	4	regulate	regulate	VERB
bibechana-21109	38	5	normal	normal	ADJ
bibechana-21109	38	6	physiological	physiological	ADJ
bibechana-21109	38	7	and	and	CCONJ
bibechana-21109	38	8	developmental	developmental	ADJ
bibechana-21109	38	9	pathways	pathway	NOUN
bibechana-21109	38	10	,	,	PUNCT
bibechana-21109	38	11	but	but	CCONJ
bibechana-21109	38	12	thr	thr	PROPN
bibechana-21109	38	13	-	-	PUNCT
bibechana-21109	38	14	mts	mts	NOUN
bibechana-21109	38	15	result	result	NOUN
bibechana-21109	38	16	neoplastic	neoplastic	ADJ
bibechana-21109	38	17	and	and	CCONJ
bibechana-21109	38	18	endocrine	endocrine	ADJ
bibechana-21109	38	19	diseases	disease	NOUN
bibechana-21109	38	20	.	.	PUNCT
bibechana-21109	39	1	(	(	PUNCT
bibechana-21109	39	2	a	a	X
bibechana-21109	39	3	)	)	PUNCT
bibechana-21109	39	4	(	(	PUNCT
bibechana-21109	39	5	b	b	X
bibechana-21109	39	6	)	)	PUNCT
bibechana-21109	39	7	(	(	PUNCT
bibechana-21109	39	8	c	c	X
bibechana-21109	39	9	)	)	PUNCT
bibechana-21109	39	10	fig	fig	NOUN
bibechana-21109	39	11	.	.	PUNCT
bibechana-21109	40	1	1	1	NUM
bibechana-21109	40	2	:	:	PUNCT
bibechana-21109	40	3	chemical	chemical	NOUN
bibechana-21109	40	4	structures	structure	NOUN
bibechana-21109	40	5	of	of	ADP
bibechana-21109	40	6	(	(	PUNCT
bibechana-21109	40	7	a	a	PRON
bibechana-21109	40	8	)	)	PUNCT
bibechana-21109	40	9	triiodothyronine	triiodothyronine	NOUN
bibechana-21109	40	10	(	(	PUNCT
bibechana-21109	40	11	t3	t3	NOUN
bibechana-21109	40	12	):	):	PUNCT
bibechana-21109	40	13	c15h12i3no4	c15h12i3no4	PROPN
bibechana-21109	40	14	with	with	ADP
bibechana-21109	40	15	molar	molar	ADJ
bibechana-21109	40	16	mass	mass	NOUN
bibechana-21109	40	17	=	=	PROPN
bibechana-21109	40	18	650.98	650.98	NUM
bibechana-21109	40	19	g	g	NOUN
bibechana-21109	40	20	/	/	SYM
bibechana-21109	40	21	mol	mol	NOUN
bibechana-21109	40	22	,	,	PUNCT
bibechana-21109	40	23	(	(	PUNCT
bibechana-21109	40	24	b	b	X
bibechana-21109	40	25	)	)	PUNCT
bibechana-21109	40	26	isoleucine	isoleucine	NOUN
bibechana-21109	40	27	(	(	PUNCT
bibechana-21109	40	28	ile	ile	PROPN
bibechana-21109	40	29	):	):	PUNCT
bibechana-21109	40	30	c6h13no2	c6h13no2	PROPN
bibechana-21109	40	31	with	with	ADP
bibechana-21109	40	32	molar	molar	ADJ
bibechana-21109	40	33	mass	mass	NOUN
bibechana-21109	40	34	=	=	SYM
bibechana-21109	41	1	131.17	131.17	NUM
bibechana-21109	41	2	g	g	NOUN
bibechana-21109	41	3	/	/	SYM
bibechana-21109	41	4	mol	mol	NOUN
bibechana-21109	41	5	and	and	CCONJ
bibechana-21109	41	6	(	(	PUNCT
bibechana-21109	41	7	c	c	NOUN
bibechana-21109	41	8	)	)	PUNCT
bibechana-21109	41	9	valine	valine	NOUN
bibechana-21109	41	10	(	(	PUNCT
bibechana-21109	41	11	val	val	NOUN
bibechana-21109	41	12	):	):	PUNCT
bibechana-21109	41	13	c5h11no2	c5h11no2	PROPN
bibechana-21109	41	14	with	with	ADP
bibechana-21109	41	15	molar	molar	ADJ
bibechana-21109	41	16	mass	mass	NOUN
bibechana-21109	41	17	=	=	SYM
bibechana-21109	41	18	117.15	117.15	NUM
bibechana-21109	41	19	g	g	NOUN
bibechana-21109	41	20	/	/	SYM
bibechana-21109	41	21	mol[prepared	mol[prepare	VERB
bibechana-21109	41	22	from	from	ADP
bibechana-21109	41	23	pymol	pymol	PROPN
bibechana-21109	41	24	molecular	molecular	ADJ
bibechana-21109	41	25	graphics	graphic	NOUN
bibechana-21109	41	26	system	system	NOUN
bibechana-21109	41	27	]	]	PUNCT
bibechana-21109	41	28	.	.	PUNCT
bibechana-21109	42	1	the	the	DET
bibechana-21109	42	2	i431v	i431v	PROPN
bibechana-21109	42	3	point	point	NOUN
bibechana-21109	42	4	mutation	mutation	NOUN
bibechana-21109	42	5	is	be	AUX
bibechana-21109	42	6	detected	detect	VERB
bibechana-21109	42	7	experimentally	experimentally	ADV
bibechana-21109	42	8	in	in	ADP
bibechana-21109	42	9	thr	thr	PROPN
bibechana-21109	42	10	-	-	PUNCT
bibechana-21109	42	11	β	β	NOUN
bibechana-21109	42	12	gene	gene	NOUN
bibechana-21109	42	13	of	of	ADP
bibechana-21109	42	14	a	a	DET
bibechana-21109	42	15	14	14	NUM
bibechana-21109	42	16	-	-	PUNCT
bibechana-21109	42	17	year	year	NOUN
bibechana-21109	42	18	-	-	PUNCT
bibechana-21109	42	19	old	old	ADJ
bibechana-21109	42	20	brazilian	brazilian	ADJ
bibechana-21109	42	21	girl	girl	NOUN
bibechana-21109	42	22	with	with	ADP
bibechana-21109	42	23	elevated	elevated	ADJ
bibechana-21109	42	24	t3	t3	PROPN
bibechana-21109	42	25	and	and	CCONJ
bibechana-21109	42	26	t4	t4	PROPN
bibechana-21109	42	27	but	but	CCONJ
bibechana-21109	42	28	unsuppressed	unsuppresse	VERB
bibechana-21109	42	29	tsh	tsh	NOUN
bibechana-21109	42	30	showing	show	VERB
bibechana-21109	42	31	rth	rth	NOUN
bibechana-21109	42	32	with	with	ADP
bibechana-21109	42	33	goiter	goiter	NOUN
bibechana-21109	43	1	[	[	X
bibechana-21109	43	2	12	12	NUM
bibechana-21109	43	3	]	]	PUNCT
bibechana-21109	43	4	.	.	PUNCT
bibechana-21109	44	1	this	this	DET
bibechana-21109	44	2	mutation	mutation	NOUN
bibechana-21109	44	3	occurs	occur	VERB
bibechana-21109	44	4	tika	tika	NOUN
bibechana-21109	44	5	ram	ram	NOUN
bibechana-21109	44	6	lamichhane	lamichhane	NOUN
bibechana-21109	44	7	et	et	PROPN
bibechana-21109	44	8	al./	al./	ADV
bibechana-21109	44	9	bibechana	bibechana	PROPN
bibechana-21109	44	10	16	16	NUM
bibechana-21109	44	11	(	(	PUNCT
bibechana-21109	44	12	2019	2019	NUM
bibechana-21109	44	13	)	)	PUNCT
bibechana-21109	44	14	79	79	NUM
bibechana-21109	44	15	-	-	SYM
bibechana-21109	44	16	91	91	NUM
bibechana-21109	44	17	:	:	PUNCT
bibechana-21109	44	18	rcost	rcost	NOUN
bibechana-21109	44	19	p.81	p.81	PROPN
bibechana-21109	44	20	(	(	PUNCT
bibechana-21109	44	21	online	online	ADJ
bibechana-21109	44	22	publication	publication	NOUN
bibechana-21109	44	23	:	:	PUNCT
bibechana-21109	44	24	dec	dec	PROPN
bibechana-21109	44	25	.	.	PROPN
bibechana-21109	44	26	,	,	PUNCT
bibechana-21109	44	27	2018	2018	NUM
bibechana-21109	44	28	)	)	PUNCT
bibechana-21109	44	29	by	by	ADP
bibechana-21109	44	30	replacing	replace	VERB
bibechana-21109	44	31	isoleucine	isoleucine	PROPN
bibechana-21109	44	32	(	(	PUNCT
bibechana-21109	44	33	ile	ile	ADJ
bibechana-21109	44	34	)	)	PUNCT
bibechana-21109	44	35	amino	amino	NOUN
bibechana-21109	44	36	acid	acid	NOUN
bibechana-21109	44	37	residue	residue	NOUN
bibechana-21109	44	38	by	by	ADP
bibechana-21109	44	39	valine	valine	NOUN
bibechana-21109	44	40	(	(	PUNCT
bibechana-21109	44	41	val	val	NOUN
bibechana-21109	44	42	)	)	PUNCT
bibechana-21109	44	43	in	in	ADP
bibechana-21109	44	44	431	431	NUM
bibechana-21109	44	45	codon	codon	NOUN
bibechana-21109	44	46	of	of	ADP
bibechana-21109	44	47	thr	thr	PROPN
bibechana-21109	44	48	-	-	PUNCT
bibechana-21109	44	49	β	β	NOUN
bibechana-21109	44	50	gene	gene	NOUN
bibechana-21109	44	51	.	.	PUNCT
bibechana-21109	45	1	i431v	i431v	PROPN
bibechana-21109	45	2	mutation	mutation	NOUN
bibechana-21109	45	3	exerts	exert	VERB
bibechana-21109	45	4	impairment	impairment	NOUN
bibechana-21109	45	5	of	of	ADP
bibechana-21109	45	6	ligand	ligand	NOUN
bibechana-21109	45	7	-	-	PUNCT
bibechana-21109	45	8	dependent	dependent	ADJ
bibechana-21109	45	9	release	release	NOUN
bibechana-21109	45	10	of	of	ADP
bibechana-21109	45	11	corepressor	corepressor	NOUN
bibechana-21109	45	12	,	,	PUNCT
bibechana-21109	45	13	silencing	silence	VERB
bibechana-21109	45	14	mediator	mediator	NOUN
bibechana-21109	45	15	for	for	ADP
bibechana-21109	45	16	retinoid	retinoid	NOUN
bibechana-21109	45	17	and	and	CCONJ
bibechana-21109	45	18	thyroid	thyroid	NOUN
bibechana-21109	45	19	receptors	receptor	NOUN
bibechana-21109	45	20	(	(	PUNCT
bibechana-21109	45	21	smrt	smrt	NOUN
bibechana-21109	45	22	)	)	PUNCT
bibechana-21109	45	23	with	with	ADP
bibechana-21109	45	24	dominant	dominant	ADJ
bibechana-21109	45	25	negative	negative	ADJ
bibechana-21109	45	26	effects	effect	NOUN
bibechana-21109	45	27	on	on	ADP
bibechana-21109	45	28	thr	thr	PROPN
bibechana-21109	45	29	-	-	PUNCT
bibechana-21109	45	30	wt	wt	NOUN
bibechana-21109	45	31	and	and	CCONJ
bibechana-21109	45	32	reducing	reduce	VERB
bibechana-21109	45	33	potency	potency	NOUN
bibechana-21109	45	34	.	.	PUNCT
bibechana-21109	46	1	the	the	DET
bibechana-21109	46	2	chemical	chemical	NOUN
bibechana-21109	46	3	structures	structure	NOUN
bibechana-21109	46	4	of	of	ADP
bibechana-21109	46	5	t3	t3	PROPN
bibechana-21109	46	6	,	,	PUNCT
bibechana-21109	46	7	ile	ile	PROPN
bibechana-21109	46	8	and	and	CCONJ
bibechana-21109	46	9	val	val	NOUN
bibechana-21109	46	10	are	be	AUX
bibechana-21109	46	11	shown	show	VERB
bibechana-21109	46	12	in	in	ADP
bibechana-21109	46	13	fig	fig	NOUN
bibechana-21109	46	14	.	.	PUNCT
bibechana-21109	47	1	1	1	X
bibechana-21109	47	2	.	.	X
bibechana-21109	47	3	ile	ile	PROPN
bibechana-21109	47	4	is	be	AUX
bibechana-21109	47	5	heavier	heavy	ADJ
bibechana-21109	47	6	and	and	CCONJ
bibechana-21109	47	7	larger	large	ADJ
bibechana-21109	47	8	in	in	ADP
bibechana-21109	47	9	size	size	NOUN
bibechana-21109	47	10	than	than	ADP
bibechana-21109	47	11	val	val	PROPN
bibechana-21109	47	12	.	.	PUNCT
bibechana-21109	48	1	t3	t3	PROPN
bibechana-21109	48	2	binding	bind	VERB
bibechana-21109	48	3	assay	assay	PROPN
bibechana-21109	49	1	[	[	X
bibechana-21109	49	2	12	12	NUM
bibechana-21109	49	3	]	]	PUNCT
bibechana-21109	49	4	shows	show	VERB
bibechana-21109	49	5	that	that	SCONJ
bibechana-21109	49	6	the	the	DET
bibechana-21109	49	7	hormone	hormone	NOUN
bibechana-21109	49	8	binding	bind	VERB
bibechana-21109	49	9	affinity	affinity	NOUN
bibechana-21109	49	10	of	of	ADP
bibechana-21109	49	11	i431v	i431v	PROPN
bibechana-21109	49	12	-	-	PUNCT
bibechana-21109	49	13	mutant	mutant	NOUN
bibechana-21109	49	14	thr	thr	PROPN
bibechana-21109	49	15	-	-	PUNCT
bibechana-21109	49	16	β	β	PROPN
bibechana-21109	49	17	is	be	AUX
bibechana-21109	49	18	2.6	2.6	NUM
bibechana-21109	49	19	times	time	NOUN
bibechana-21109	49	20	lower	low	ADJ
bibechana-21109	49	21	than	than	ADP
bibechana-21109	49	22	that	that	PRON
bibechana-21109	49	23	in	in	ADP
bibechana-21109	49	24	wild	wild	ADJ
bibechana-21109	49	25	type	type	NOUN
bibechana-21109	49	26	thr	thr	PROPN
bibechana-21109	49	27	-	-	PUNCT
bibechana-21109	49	28	β	β	NOUN
bibechana-21109	49	29	.	.	PUNCT
bibechana-21109	50	1	thr	thr	PROPN
bibechana-21109	50	2	-	-	PUNCT
bibechana-21109	50	3	wt	wt	NOUN
bibechana-21109	50	4	,	,	PUNCT
bibechana-21109	50	5	thrt3	thrt3	NOUN
bibechana-21109	50	6	-	-	PUNCT
bibechana-21109	50	7	wt	wt	NOUN
bibechana-21109	50	8	and	and	CCONJ
bibechana-21109	50	9	thrt3	thrt3	PROPN
bibechana-21109	50	10	-	-	PUNCT
bibechana-21109	50	11	mt	mt	PROPN
bibechana-21109	50	12	show	show	VERB
bibechana-21109	50	13	the	the	DET
bibechana-21109	50	14	distinct	distinct	ADJ
bibechana-21109	50	15	features	feature	NOUN
bibechana-21109	50	16	reflecting	reflect	VERB
bibechana-21109	50	17	in	in	ADP
bibechana-21109	50	18	terms	term	NOUN
bibechana-21109	50	19	of	of	ADP
bibechana-21109	50	20	root	root	NOUN
bibechana-21109	50	21	mean	mean	ADJ
bibechana-21109	50	22	square	square	ADJ
bibechana-21109	50	23	deviation	deviation	NOUN
bibechana-21109	50	24	(	(	PUNCT
bibechana-21109	50	25	rmsd	rmsd	NOUN
bibechana-21109	50	26	)	)	PUNCT
bibechana-21109	50	27	,	,	PUNCT
bibechana-21109	50	28	radius	radius	NOUN
bibechana-21109	50	29	of	of	ADP
bibechana-21109	50	30	gyration	gyration	NOUN
bibechana-21109	50	31	(	(	PUNCT
bibechana-21109	50	32	rg	rg	NOUN
bibechana-21109	50	33	)	)	PUNCT
bibechana-21109	50	34	,	,	PUNCT
bibechana-21109	50	35	root	root	NOUN
bibechana-21109	50	36	mean	mean	VERB
bibechana-21109	50	37	square	square	ADJ
bibechana-21109	50	38	fluctuation	fluctuation	NOUN
bibechana-21109	50	39	(	(	PUNCT
bibechana-21109	50	40	rmsf	rmsf	NOUN
bibechana-21109	50	41	)	)	PUNCT
bibechana-21109	50	42	,	,	PUNCT
bibechana-21109	50	43	ir	ir	PROPN
bibechana-21109	50	44	spectra	spectra	PROPN
bibechana-21109	50	45	,	,	PUNCT
bibechana-21109	50	46	radial	radial	ADJ
bibechana-21109	50	47	distribution	distribution	NOUN
bibechana-21109	50	48	functions	function	NOUN
bibechana-21109	50	49	,	,	PUNCT
bibechana-21109	50	50	solvent	solvent	ADJ
bibechana-21109	50	51	accessible	accessible	ADJ
bibechana-21109	50	52	surface	surface	NOUN
bibechana-21109	50	53	area	area	NOUN
bibechana-21109	50	54	(	(	PUNCT
bibechana-21109	50	55	sasa	sasa	PROPN
bibechana-21109	50	56	)	)	PUNCT
bibechana-21109	50	57	,	,	PUNCT
bibechana-21109	50	58	interaction	interaction	NOUN
bibechana-21109	50	59	energy	energy	NOUN
bibechana-21109	50	60	,	,	PUNCT
bibechana-21109	50	61	internal	internal	ADJ
bibechana-21109	50	62	energy	energy	NOUN
bibechana-21109	50	63	,	,	PUNCT
bibechana-21109	50	64	etc	etc	X
bibechana-21109	50	65	.	.	X
bibechana-21109	51	1	the	the	DET
bibechana-21109	51	2	structural	structural	ADJ
bibechana-21109	51	3	and	and	CCONJ
bibechana-21109	51	4	physical	physical	ADJ
bibechana-21109	51	5	properties	property	NOUN
bibechana-21109	51	6	of	of	ADP
bibechana-21109	51	7	the	the	DET
bibechana-21109	51	8	wild	wild	ADJ
bibechana-21109	51	9	type	type	NOUN
bibechana-21109	51	10	and	and	CCONJ
bibechana-21109	51	11	the	the	DET
bibechana-21109	51	12	mutated	mutate	VERB
bibechana-21109	51	13	protein	protein	NOUN
bibechana-21109	51	14	-	-	PUNCT
bibechana-21109	51	15	hormone	hormone	NOUN
bibechana-21109	51	16	systems	system	NOUN
bibechana-21109	51	17	can	can	AUX
bibechana-21109	51	18	be	be	AUX
bibechana-21109	51	19	studied	study	VERB
bibechana-21109	51	20	by	by	ADP
bibechana-21109	51	21	using	use	VERB
bibechana-21109	51	22	molecular	molecular	ADJ
bibechana-21109	51	23	dynamics	dynamic	NOUN
bibechana-21109	51	24	simulations	simulation	NOUN
bibechana-21109	51	25	(	(	PUNCT
bibechana-21109	51	26	mds	mds	PROPN
bibechana-21109	51	27	)	)	PUNCT
bibechana-21109	51	28	.	.	PUNCT
bibechana-21109	52	1	(	(	PUNCT
bibechana-21109	52	2	a	a	X
bibechana-21109	52	3	)	)	PUNCT
bibechana-21109	52	4	(	(	PUNCT
bibechana-21109	52	5	b	b	X
bibechana-21109	52	6	)	)	PUNCT
bibechana-21109	52	7	(	(	PUNCT
bibechana-21109	52	8	c	c	X
bibechana-21109	52	9	)	)	PUNCT
bibechana-21109	52	10	fig.2	fig.2	PROPN
bibechana-21109	52	11	:	:	PUNCT
bibechana-21109	52	12	(	(	PUNCT
bibechana-21109	52	13	a	a	X
bibechana-21109	52	14	)	)	PUNCT
bibechana-21109	52	15	wild	wild	ADJ
bibechana-21109	52	16	type	type	NOUN
bibechana-21109	52	17	thr	thr	PROPN
bibechana-21109	52	18	-	-	PUNCT
bibechana-21109	52	19	β	β	NOUN
bibechana-21109	52	20	highlighting	highlight	VERB
bibechana-21109	52	21	with	with	ADP
bibechana-21109	52	22	i431	i431	PROPN
bibechana-21109	52	23	codon	codon	NOUN
bibechana-21109	52	24	and	and	CCONJ
bibechana-21109	52	25	t3	t3	PROPN
bibechana-21109	52	26	hormone	hormone	NOUN
bibechana-21109	52	27	,	,	PUNCT
bibechana-21109	52	28	(	(	PUNCT
bibechana-21109	52	29	b	b	X
bibechana-21109	52	30	)	)	PUNCT
bibechana-21109	52	31	i431v	i431v	PROPN
bibechana-21109	52	32	-	-	PUNCT
bibechana-21109	52	33	mutant	mutant	NOUN
bibechana-21109	52	34	on	on	ADP
bibechana-21109	52	35	thr	thr	PROPN
bibechana-21109	52	36	-	-	PUNCT
bibechana-21109	52	37	β	β	NOUN
bibechana-21109	52	38	gene	gene	NOUN
bibechana-21109	52	39	and	and	CCONJ
bibechana-21109	52	40	(	(	PUNCT
bibechana-21109	52	41	c	c	NOUN
bibechana-21109	52	42	)	)	PUNCT
bibechana-21109	52	43	experimentally	experimentally	ADV
bibechana-21109	52	44	observed	observe	VERB
bibechana-21109	52	45	mutational	mutational	ADJ
bibechana-21109	52	46	sites	site	NOUN
bibechana-21109	52	47	on	on	ADP
bibechana-21109	52	48	thr	thr	PROPN
bibechana-21109	52	49	-	-	PUNCT
bibechana-21109	52	50	β	β	NOUN
bibechana-21109	52	51	gene	gene	NOUN
bibechana-21109	52	52	[	[	X
bibechana-21109	52	53	7	7	NUM
bibechana-21109	52	54	-	-	SYM
bibechana-21109	52	55	12	12	NUM
bibechana-21109	52	56	]	]	PUNCT
bibechana-21109	52	57	.	.	PUNCT
bibechana-21109	53	1	the	the	DET
bibechana-21109	53	2	images	image	NOUN
bibechana-21109	53	3	are	be	AUX
bibechana-21109	53	4	prepared	prepare	VERB
bibechana-21109	53	5	from	from	ADP
bibechana-21109	53	6	pymol	pymol	PROPN
bibechana-21109	53	7	molecular	molecular	ADJ
bibechana-21109	53	8	graphics	graphic	NOUN
bibechana-21109	53	9	system	system	NOUN
bibechana-21109	53	10	.	.	PUNCT
bibechana-21109	54	1	2	2	X
bibechana-21109	54	2	.	.	X
bibechana-21109	54	3	methodology	methodology	NOUN
bibechana-21109	54	4	the	the	DET
bibechana-21109	54	5	structure	structure	NOUN
bibechana-21109	54	6	of	of	ADP
bibechana-21109	54	7	wild	wild	ADJ
bibechana-21109	54	8	type	type	NOUN
bibechana-21109	54	9	thrt3	thrt3	PRON
bibechana-21109	54	10	was	be	AUX
bibechana-21109	54	11	taken	take	VERB
bibechana-21109	54	12	from	from	ADP
bibechana-21109	54	13	the	the	DET
bibechana-21109	54	14	x	x	NOUN
bibechana-21109	54	15	-	-	NOUN
bibechana-21109	54	16	ray	ray	NOUN
bibechana-21109	54	17	crystallographic	crystallographic	ADJ
bibechana-21109	54	18	data	datum	NOUN
bibechana-21109	54	19	of	of	ADP
bibechana-21109	54	20	protein	protein	NOUN
bibechana-21109	54	21	data	datum	NOUN
bibechana-21109	54	22	bank	bank	PROPN
bibechana-21109	54	23	code-3gws	code-3gws	PROPN
bibechana-21109	55	1	[	[	X
bibechana-21109	55	2	15	15	NUM
bibechana-21109	55	3	]	]	PUNCT
bibechana-21109	55	4	.	.	PUNCT
bibechana-21109	56	1	the	the	DET
bibechana-21109	56	2	charmm	charmm	PROPN
bibechana-21109	56	3	force	force	NOUN
bibechana-21109	56	4	field	field	NOUN
bibechana-21109	56	5	topologies	topology	NOUN
bibechana-21109	56	6	and	and	CCONJ
bibechana-21109	56	7	parameters	parameter	NOUN
bibechana-21109	56	8	[	[	X
bibechana-21109	56	9	16	16	NUM
bibechana-21109	56	10	,	,	PUNCT
bibechana-21109	56	11	17	17	NUM
bibechana-21109	56	12	,	,	PUNCT
bibechana-21109	56	13	18	18	NUM
bibechana-21109	56	14	,	,	PUNCT
bibechana-21109	56	15	19	19	NUM
bibechana-21109	56	16	]	]	PUNCT
bibechana-21109	56	17	were	be	AUX
bibechana-21109	56	18	used	use	VERB
bibechana-21109	56	19	for	for	ADP
bibechana-21109	56	20	mds	mds	NOUN
bibechana-21109	56	21	of	of	ADP
bibechana-21109	56	22	the	the	DET
bibechana-21109	56	23	protein	protein	NOUN
bibechana-21109	56	24	-	-	PUNCT
bibechana-21109	56	25	hormone	hormone	NOUN
bibechana-21109	56	26	systems	system	NOUN
bibechana-21109	56	27	.	.	PUNCT
bibechana-21109	57	1	the	the	DET
bibechana-21109	57	2	hetero	hetero	NOUN
bibechana-21109	57	3	-	-	PUNCT
bibechana-21109	57	4	atomic	atomic	NOUN
bibechana-21109	57	5	t3	t3	NOUN
bibechana-21109	57	6	-	-	PUNCT
bibechana-21109	57	7	hormone	hormone	NOUN
bibechana-21109	57	8	was	be	AUX
bibechana-21109	57	9	parameterized	parameterized	ADJ
bibechana-21109	57	10	first	first	ADV
bibechana-21109	57	11	to	to	PART
bibechana-21109	57	12	describe	describe	VERB
bibechana-21109	57	13	its	its	PRON
bibechana-21109	57	14	molecular	molecular	ADJ
bibechana-21109	57	15	geometry	geometry	NOUN
bibechana-21109	57	16	,	,	PUNCT
bibechana-21109	57	17	atomic	atomic	ADJ
bibechana-21109	57	18	masses	masse	NOUN
bibechana-21109	57	19	,	,	PUNCT
bibechana-21109	57	20	charges	charge	NOUN
bibechana-21109	57	21	and	and	CCONJ
bibechana-21109	57	22	torsion	torsion	NOUN
bibechana-21109	57	23	barriers	barrier	NOUN
bibechana-21109	57	24	[	[	X
bibechana-21109	57	25	19	19	NUM
bibechana-21109	57	26	]	]	PUNCT
bibechana-21109	57	27	.	.	PUNCT
bibechana-21109	58	1	the	the	DET
bibechana-21109	58	2	generation	generation	NOUN
bibechana-21109	58	3	of	of	ADP
bibechana-21109	58	4	the	the	DET
bibechana-21109	58	5	complete	complete	ADJ
bibechana-21109	58	6	systems	system	NOUN
bibechana-21109	58	7	of	of	ADP
bibechana-21109	58	8	thr	thr	PROPN
bibechana-21109	58	9	-	-	PUNCT
bibechana-21109	58	10	wt	wt	NOUN
bibechana-21109	58	11	,	,	PUNCT
bibechana-21109	58	12	thrt3	thrt3	NOUN
bibechana-21109	58	13	-	-	PUNCT
bibechana-21109	58	14	wt	wt	NOUN
bibechana-21109	58	15	and	and	CCONJ
bibechana-21109	58	16	thrt3	thrt3	PROPN
bibechana-21109	58	17	-	-	PUNCT
bibechana-21109	58	18	mt	mt	PROPN
bibechana-21109	58	19	starting	start	VERB
bibechana-21109	58	20	from	from	ADP
bibechana-21109	58	21	their	their	PRON
bibechana-21109	58	22	protein	protein	NOUN
bibechana-21109	58	23	structure	structure	NOUN
bibechana-21109	58	24	files	file	NOUN
bibechana-21109	58	25	to	to	ADP
bibechana-21109	58	26	the	the	DET
bibechana-21109	58	27	solvation	solvation	NOUN
bibechana-21109	58	28	in	in	ADP
bibechana-21109	58	29	neutral	neutral	ADJ
bibechana-21109	58	30	water	water	NOUN
bibechana-21109	58	31	-	-	PUNCT
bibechana-21109	58	32	ion	ion	NOUN
bibechana-21109	58	33	environment	environment	NOUN
bibechana-21109	58	34	,	,	PUNCT
bibechana-21109	58	35	equilibration	equilibration	NOUN
bibechana-21109	58	36	,	,	PUNCT
bibechana-21109	58	37	production	production	NOUN
bibechana-21109	58	38	runs	run	NOUN
bibechana-21109	58	39	and	and	CCONJ
bibechana-21109	58	40	analysis	analysis	NOUN
bibechana-21109	58	41	of	of	ADP
bibechana-21109	58	42	the	the	DET
bibechana-21109	58	43	results	result	NOUN
bibechana-21109	58	44	were	be	AUX
bibechana-21109	58	45	performed	perform	VERB
bibechana-21109	58	46	by	by	ADP
bibechana-21109	58	47	using	use	VERB
bibechana-21109	58	48	the	the	DET
bibechana-21109	58	49	interfaces	interface	NOUN
bibechana-21109	58	50	of	of	ADP
bibechana-21109	58	51	visual	visual	ADJ
bibechana-21109	58	52	molecular	molecular	ADJ
bibechana-21109	58	53	dynamics	dynamic	NOUN
bibechana-21109	58	54	(	(	PUNCT
bibechana-21109	58	55	vmd	vmd	NOUN
bibechana-21109	58	56	)	)	PUNCT
bibechana-21109	59	1	[	[	X
bibechana-21109	59	2	20	20	NUM
bibechana-21109	59	3	]	]	PUNCT
bibechana-21109	59	4	and	and	CCONJ
bibechana-21109	59	5	nanoscale	nanoscale	NOUN
bibechana-21109	59	6	molecular	molecular	ADJ
bibechana-21109	59	7	dynamics	dynamic	NOUN
bibechana-21109	59	8	(	(	PUNCT
bibechana-21109	59	9	namd	namd	NOUN
bibechana-21109	59	10	)	)	PUNCT
bibechana-21109	60	1	[	[	X
bibechana-21109	60	2	21	21	NUM
bibechana-21109	60	3	]	]	X
bibechana-21109	60	4	computational	computational	ADJ
bibechana-21109	60	5	packages	package	NOUN
bibechana-21109	60	6	.	.	PUNCT
bibechana-21109	61	1	from	from	ADP
bibechana-21109	61	2	the	the	DET
bibechana-21109	61	3	wild	wild	ADJ
bibechana-21109	61	4	type	type	NOUN
bibechana-21109	61	5	native	native	ADJ
bibechana-21109	61	6	structure	structure	NOUN
bibechana-21109	61	7	of	of	ADP
bibechana-21109	61	8	thrt3	thrt3	PROPN
bibechana-21109	61	9	,	,	PUNCT
bibechana-21109	61	10	the	the	DET
bibechana-21109	61	11	mutated	mutated	ADJ
bibechana-21109	61	12	thrt3	thrt3	PRON
bibechana-21109	61	13	was	be	AUX
bibechana-21109	61	14	made	make	VERB
bibechana-21109	61	15	after	after	ADP
bibechana-21109	61	16	the	the	DET
bibechana-21109	61	17	point	point	NOUN
bibechana-21109	61	18	mutation	mutation	NOUN
bibechana-21109	61	19	on	on	ADP
bibechana-21109	61	20	431	431	NUM
bibechana-21109	61	21	-	-	PUNCT
bibechana-21109	61	22	codon	codon	ADJ
bibechana-21109	61	23	replacing	replacing	NOUN
bibechana-21109	61	24	ile	ile	NOUN
bibechana-21109	61	25	by	by	ADP
bibechana-21109	61	26	val	val	NOUN
bibechana-21109	61	27	with	with	ADP
bibechana-21109	61	28	the	the	DET
bibechana-21109	61	29	help	help	NOUN
bibechana-21109	61	30	of	of	ADP
bibechana-21109	61	31	vmd	vmd	PROPN
bibechana-21109	61	32	-	-	NOUN
bibechana-21109	61	33	mutagenesis	mutagenesis	NOUN
bibechana-21109	61	34	.	.	PUNCT
bibechana-21109	62	1	unliganded	unligande	VERB
bibechana-21109	62	2	thr	thr	PROPN
bibechana-21109	62	3	-	-	PUNCT
bibechana-21109	62	4	wt	wt	NOUN
bibechana-21109	62	5	,	,	PUNCT
bibechana-21109	62	6	t3	t3	NOUN
bibechana-21109	62	7	-	-	PUNCT
bibechana-21109	62	8	liganded	ligande	VERB
bibechana-21109	62	9	thrt3	thrt3	NOUN
bibechana-21109	62	10	-	-	PUNCT
bibechana-21109	62	11	wt	wt	NOUN
bibechana-21109	62	12	and	and	CCONJ
bibechana-21109	62	13	i431v	i431v	PROPN
bibechana-21109	62	14	-	-	PUNCT
bibechana-21109	62	15	mutant	mutant	NOUN
bibechana-21109	62	16	thrt3	thrt3	PROPN
bibechana-21109	62	17	-	-	PUNCT
bibechana-21109	62	18	mt	mt	PROPN
bibechana-21109	62	19	were	be	AUX
bibechana-21109	62	20	solvated	solvate	VERB
bibechana-21109	62	21	separately	separately	ADV
bibechana-21109	62	22	in	in	ADP
bibechana-21109	62	23	the	the	DET
bibechana-21109	62	24	tip3p	tip3p	NOUN
bibechana-21109	62	25	water	water	NOUN
bibechana-21109	62	26	-	-	PUNCT
bibechana-21109	62	27	box	box	NOUN
bibechana-21109	62	28	tika	tika	NOUN
bibechana-21109	62	29	ram	ram	NOUN
bibechana-21109	62	30	lamichhane	lamichhane	NOUN
bibechana-21109	62	31	et	et	PROPN
bibechana-21109	62	32	al./	al./	ADV
bibechana-21109	62	33	bibechana	bibechana	PROPN
bibechana-21109	62	34	16	16	NUM
bibechana-21109	62	35	(	(	PUNCT
bibechana-21109	62	36	2019	2019	NUM
bibechana-21109	62	37	)	)	PUNCT
bibechana-21109	62	38	79	79	NUM
bibechana-21109	62	39	-	-	SYM
bibechana-21109	62	40	91	91	NUM
bibechana-21109	62	41	:	:	PUNCT
bibechana-21109	62	42	rcost	rcost	NOUN
bibechana-21109	62	43	p.82	p.82	PROPN
bibechana-21109	62	44	(	(	PUNCT
bibechana-21109	62	45	online	online	ADJ
bibechana-21109	62	46	publication	publication	NOUN
bibechana-21109	62	47	:	:	PUNCT
bibechana-21109	62	48	dec	dec	PROPN
bibechana-21109	62	49	.	.	PROPN
bibechana-21109	62	50	,	,	PUNCT
bibechana-21109	62	51	2018	2018	NUM
bibechana-21109	62	52	)	)	PUNCT
bibechana-21109	62	53	which	which	PRON
bibechana-21109	62	54	was	be	AUX
bibechana-21109	62	55	neutralized	neutralize	VERB
bibechana-21109	62	56	with	with	ADP
bibechana-21109	62	57	na+	na+	NOUN
bibechana-21109	62	58	&	&	CCONJ
bibechana-21109	62	59	clions	clion	NOUN
bibechana-21109	62	60	in	in	ADP
bibechana-21109	62	61	the	the	DET
bibechana-21109	62	62	concentration	concentration	NOUN
bibechana-21109	62	63	of	of	ADP
bibechana-21109	62	64	0.15	0.15	NUM
bibechana-21109	62	65	mol	mol	NOUN
bibechana-21109	62	66	/	/	SYM
bibechana-21109	62	67	l.	l.	PROPN
bibechana-21109	62	68	each	each	DET
bibechana-21109	62	69	water	water	NOUN
bibechana-21109	62	70	-	-	PUNCT
bibechana-21109	62	71	box	box	NOUN
bibechana-21109	62	72	has	have	VERB
bibechana-21109	62	73	the	the	DET
bibechana-21109	62	74	periodic	periodic	ADJ
bibechana-21109	62	75	cell	cell	NOUN
bibechana-21109	62	76	basis	basis	NOUN
bibechana-21109	62	77	vectors	vector	NOUN
bibechana-21109	62	78	50.35	50.35	NUM
bibechana-21109	62	79	,	,	PUNCT
bibechana-21109	62	80	61.92	61.92	NUM
bibechana-21109	62	81	and	and	CCONJ
bibechana-21109	62	82	74.78	74.78	NUM
bibechana-21109	62	83	å	å	PROPN
bibechana-21109	62	84	along	along	ADP
bibechana-21109	62	85	x	x	PROPN
bibechana-21109	62	86	,	,	PUNCT
bibechana-21109	62	87	y	y	PROPN
bibechana-21109	62	88	and	and	CCONJ
bibechana-21109	62	89	z	z	NOUN
bibechana-21109	62	90	-	-	PUNCT
bibechana-21109	62	91	axes	axis	NOUN
bibechana-21109	62	92	,	,	PUNCT
bibechana-21109	62	93	respectively	respectively	ADV
bibechana-21109	62	94	.	.	PUNCT
bibechana-21109	63	1	configuration	configuration	NOUN
bibechana-21109	63	2	files	file	NOUN
bibechana-21109	63	3	were	be	AUX
bibechana-21109	63	4	prepared	prepare	VERB
bibechana-21109	63	5	by	by	ADP
bibechana-21109	63	6	writing	write	VERB
bibechana-21109	63	7	tcl	tcl	NOUN
bibechana-21109	63	8	-	-	PUNCT
bibechana-21109	63	9	scripts	script	NOUN
bibechana-21109	63	10	to	to	PART
bibechana-21109	63	11	simulate	simulate	VERB
bibechana-21109	63	12	the	the	DET
bibechana-21109	63	13	systems	system	NOUN
bibechana-21109	63	14	for	for	ADP
bibechana-21109	63	15	which	which	PRON
bibechana-21109	63	16	langevin	langevin	ADJ
bibechana-21109	63	17	piston	piston	NOUN
bibechana-21109	63	18	temperature	temperature	NOUN
bibechana-21109	63	19	,	,	PUNCT
bibechana-21109	63	20	pressure	pressure	NOUN
bibechana-21109	63	21	and	and	CCONJ
bibechana-21109	63	22	damping	damp	VERB
bibechana-21109	63	23	coefficient	coefficient	NOUN
bibechana-21109	63	24	are	be	AUX
bibechana-21109	63	25	310	310	NUM
bibechana-21109	63	26	k	k	NOUN
bibechana-21109	63	27	,	,	PUNCT
bibechana-21109	63	28	1	1	NUM
bibechana-21109	63	29	bar	bar	NOUN
bibechana-21109	63	30	and	and	CCONJ
bibechana-21109	63	31	1	1	NUM
bibechana-21109	63	32	ps-1	ps-1	NOUN
bibechana-21109	63	33	,	,	PUNCT
bibechana-21109	63	34	respectively	respectively	ADV
bibechana-21109	63	35	.	.	PUNCT
bibechana-21109	64	1	oscillation	oscillation	NOUN
bibechana-21109	64	2	period	period	NOUN
bibechana-21109	64	3	of	of	ADP
bibechana-21109	64	4	the	the	DET
bibechana-21109	64	5	piston	piston	NOUN
bibechana-21109	64	6	was	be	AUX
bibechana-21109	64	7	100	100	NUM
bibechana-21109	64	8	fs	f	NOUN
bibechana-21109	64	9	with	with	ADP
bibechana-21109	64	10	decay	decay	NOUN
bibechana-21109	64	11	time	time	NOUN
bibechana-21109	64	12	of	of	ADP
bibechana-21109	64	13	50	50	NUM
bibechana-21109	64	14	fs	f	NOUN
bibechana-21109	64	15	and	and	CCONJ
bibechana-21109	64	16	periodic	periodic	ADJ
bibechana-21109	64	17	cell	cell	NOUN
bibechana-21109	64	18	fluctuation	fluctuation	NOUN
bibechana-21109	64	19	was	be	AUX
bibechana-21109	64	20	isotropic	isotropic	ADJ
bibechana-21109	64	21	.	.	PUNCT
bibechana-21109	65	1	the	the	DET
bibechana-21109	65	2	langevin	langevin	PROPN
bibechana-21109	65	3	dynamics	dynamic	NOUN
bibechana-21109	65	4	[	[	X
bibechana-21109	65	5	22	22	NUM
bibechana-21109	65	6	,	,	PUNCT
bibechana-21109	65	7	23	23	NUM
bibechana-21109	65	8	]	]	PUNCT
bibechana-21109	65	9	was	be	AUX
bibechana-21109	65	10	applied	apply	VERB
bibechana-21109	65	11	for	for	ADP
bibechana-21109	65	12	all	all	DET
bibechana-21109	65	13	atoms	atom	NOUN
bibechana-21109	65	14	except	except	SCONJ
bibechana-21109	65	15	hydrogens	hydrogen	NOUN
bibechana-21109	65	16	of	of	ADP
bibechana-21109	65	17	the	the	DET
bibechana-21109	65	18	systems	system	NOUN
bibechana-21109	65	19	.	.	PUNCT
bibechana-21109	66	1	particle	particle	NOUN
bibechana-21109	66	2	mesh	mesh	PROPN
bibechana-21109	66	3	ewald	ewald	PROPN
bibechana-21109	66	4	(	(	PUNCT
bibechana-21109	66	5	pme	pme	PROPN
bibechana-21109	66	6	)	)	PUNCT
bibechana-21109	66	7	was	be	AUX
bibechana-21109	66	8	active	active	ADJ
bibechana-21109	66	9	with	with	ADP
bibechana-21109	66	10	the	the	DET
bibechana-21109	66	11	grid	grid	NOUN
bibechana-21109	66	12	dimensions	dimension	NOUN
bibechana-21109	66	13	of	of	ADP
bibechana-21109	66	14	(	(	PUNCT
bibechana-21109	66	15	54	54	NUM
bibechana-21109	66	16	,	,	PUNCT
bibechana-21109	66	17	64	64	NUM
bibechana-21109	66	18	,	,	PUNCT
bibechana-21109	66	19	80å	80å	NOUN
bibechana-21109	66	20	)	)	PUNCT
bibechana-21109	66	21	and	and	CCONJ
bibechana-21109	66	22	the	the	DET
bibechana-21109	66	23	pme	pme	PROPN
bibechana-21109	66	24	coefficient	coefficient	NOUN
bibechana-21109	66	25	of	of	ADP
bibechana-21109	66	26	0.258	0.258	NUM
bibechana-21109	66	27	for	for	ADP
bibechana-21109	66	28	the	the	DET
bibechana-21109	66	29	electrostatic	electrostatic	ADJ
bibechana-21109	66	30	force	force	NOUN
bibechana-21109	66	31	evaluation	evaluation	NOUN
bibechana-21109	66	32	[	[	X
bibechana-21109	66	33	24	24	NUM
bibechana-21109	66	34	]	]	PUNCT
bibechana-21109	66	35	.	.	PUNCT
bibechana-21109	67	1	in	in	ADP
bibechana-21109	67	2	adjusting	adjust	VERB
bibechana-21109	67	3	the	the	DET
bibechana-21109	67	4	force	force	NOUN
bibechana-21109	67	5	field	field	NOUN
bibechana-21109	67	6	parameters	parameter	NOUN
bibechana-21109	67	7	used	use	VERB
bibechana-21109	67	8	in	in	ADP
bibechana-21109	67	9	mds	mds	PROPN
bibechana-21109	67	10	,	,	PUNCT
bibechana-21109	67	11	1	1	NUM
bibechana-21109	67	12	-	-	SYM
bibechana-21109	67	13	4	4	NUM
bibechana-21109	67	14	scaling	scaling	NOUN
bibechana-21109	67	15	was	be	AUX
bibechana-21109	67	16	1.0	1.0	NUM
bibechana-21109	67	17	;	;	PUNCT
bibechana-21109	67	18	cut	cut	VERB
bibechana-21109	67	19	-	-	PUNCT
bibechana-21109	67	20	off	off	NOUN
bibechana-21109	67	21	,	,	PUNCT
bibechana-21109	67	22	switching	switching	NOUN
bibechana-21109	67	23	and	and	CCONJ
bibechana-21109	67	24	pair	pair	NOUN
bibechana-21109	67	25	-	-	PUNCT
bibechana-21109	67	26	list	list	NOUN
bibechana-21109	67	27	distances	distance	NOUN
bibechana-21109	67	28	for	for	ADP
bibechana-21109	67	29	the	the	DET
bibechana-21109	67	30	electrostatic	electrostatic	ADJ
bibechana-21109	67	31	and	and	CCONJ
bibechana-21109	67	32	van	van	PROPN
bibechana-21109	67	33	der	der	NOUN
bibechana-21109	67	34	waals	waal	NOUN
bibechana-21109	67	35	interactions	interaction	NOUN
bibechana-21109	67	36	were	be	AUX
bibechana-21109	67	37	12	12	NUM
bibechana-21109	67	38	,	,	PUNCT
bibechana-21109	67	39	10	10	NUM
bibechana-21109	67	40	and	and	CCONJ
bibechana-21109	67	41	14	14	NUM
bibechana-21109	67	42	å	å	NOUN
bibechana-21109	67	43	,	,	PUNCT
bibechana-21109	67	44	respectively	respectively	ADV
bibechana-21109	67	45	.	.	PUNCT
bibechana-21109	68	1	finally	finally	ADV
bibechana-21109	68	2	,	,	PUNCT
bibechana-21109	68	3	each	each	DET
bibechana-21109	68	4	system	system	NOUN
bibechana-21109	68	5	was	be	AUX
bibechana-21109	68	6	geometrically	geometrically	ADV
bibechana-21109	68	7	optimized	optimize	VERB
bibechana-21109	68	8	with	with	ADP
bibechana-21109	68	9	3000	3000	NUM
bibechana-21109	68	10	conjugate	conjugate	ADJ
bibechana-21109	68	11	gradient	gradient	NOUN
bibechana-21109	68	12	steps	step	NOUN
bibechana-21109	68	13	and	and	CCONJ
bibechana-21109	68	14	then	then	ADV
bibechana-21109	68	15	it	it	PRON
bibechana-21109	68	16	was	be	AUX
bibechana-21109	68	17	equilibrated	equilibrate	VERB
bibechana-21109	68	18	up	up	ADP
bibechana-21109	68	19	to	to	ADP
bibechana-21109	68	20	2ns	2ns	NOUN
bibechana-21109	68	21	at	at	ADP
bibechana-21109	68	22	310	310	NUM
bibechana-21109	68	23	k.	k.	NOUN
bibechana-21109	68	24	to	to	PART
bibechana-21109	68	25	calculate	calculate	VERB
bibechana-21109	68	26	the	the	DET
bibechana-21109	68	27	trajectory	trajectory	NOUN
bibechana-21109	68	28	of	of	ADP
bibechana-21109	68	29	atomic	atomic	ADJ
bibechana-21109	68	30	particles	particle	NOUN
bibechana-21109	68	31	,	,	PUNCT
bibechana-21109	68	32	the	the	DET
bibechana-21109	68	33	velocity	velocity	NOUN
bibechana-21109	68	34	verlet	verlet	NOUN
bibechana-21109	68	35	algorithm	algorithm	NOUN
bibechana-21109	69	1	[	[	X
bibechana-21109	69	2	25	25	NUM
bibechana-21109	69	3	]	]	PUNCT
bibechana-21109	69	4	was	be	AUX
bibechana-21109	69	5	used	use	VERB
bibechana-21109	69	6	during	during	ADP
bibechana-21109	69	7	mds	mds	NOUN
bibechana-21109	69	8	of	of	ADP
bibechana-21109	69	9	the	the	DET
bibechana-21109	69	10	systems	system	NOUN
bibechana-21109	69	11	.	.	PUNCT
bibechana-21109	70	1	all	all	DET
bibechana-21109	70	2	the	the	DET
bibechana-21109	70	3	simulations	simulation	NOUN
bibechana-21109	70	4	were	be	AUX
bibechana-21109	70	5	performed	perform	VERB
bibechana-21109	70	6	adjusting	adjust	VERB
bibechana-21109	70	7	integrator	integrator	ADJ
bibechana-21109	70	8	parameters	parameter	NOUN
bibechana-21109	70	9	of	of	ADP
bibechana-21109	70	10	2	2	NUM
bibechana-21109	70	11	fs	fs	NOUN
bibechana-21109	70	12	/	/	SYM
bibechana-21109	70	13	step	step	NOUN
bibechana-21109	70	14	constrained	constrain	VERB
bibechana-21109	70	15	with	with	ADP
bibechana-21109	70	16	rigid	rigid	ADJ
bibechana-21109	70	17	bonds	bond	NOUN
bibechana-21109	70	18	of	of	ADP
bibechana-21109	70	19	h	h	NOUN
bibechana-21109	70	20	-	-	PUNCT
bibechana-21109	70	21	atoms	atom	NOUN
bibechana-21109	70	22	.	.	PUNCT
bibechana-21109	71	1	conformational	conformational	ADJ
bibechana-21109	71	2	stability	stability	NOUN
bibechana-21109	71	3	of	of	ADP
bibechana-21109	71	4	the	the	DET
bibechana-21109	71	5	protein	protein	NOUN
bibechana-21109	71	6	-	-	PUNCT
bibechana-21109	71	7	hormone	hormone	NOUN
bibechana-21109	71	8	systems	system	NOUN
bibechana-21109	71	9	was	be	AUX
bibechana-21109	71	10	tested	test	VERB
bibechana-21109	71	11	by	by	ADP
bibechana-21109	71	12	plotting	plot	VERB
bibechana-21109	71	13	rmsd	rmsd	NOUN
bibechana-21109	71	14	,	,	PUNCT
bibechana-21109	71	15	rg	rg	NOUN
bibechana-21109	71	16	,	,	PUNCT
bibechana-21109	71	17	rmsf	rmsf	NOUN
bibechana-21109	71	18	and	and	CCONJ
bibechana-21109	71	19	sasa	sasa	NOUN
bibechana-21109	71	20	of	of	ADP
bibechana-21109	71	21	protein	protein	NOUN
bibechana-21109	71	22	backbone	backbone	NOUN
bibechana-21109	71	23	,	,	PUNCT
bibechana-21109	71	24	t3	t3	NOUN
bibechana-21109	71	25	-	-	PUNCT
bibechana-21109	71	26	hormone	hormone	NOUN
bibechana-21109	71	27	and	and	CCONJ
bibechana-21109	71	28	residues	residue	NOUN
bibechana-21109	71	29	of	of	ADP
bibechana-21109	71	30	interest	interest	NOUN
bibechana-21109	71	31	:	:	PUNCT
bibechana-21109	71	32	i431	i431	PROPN
bibechana-21109	71	33	and	and	CCONJ
bibechana-21109	71	34	i431v	i431v	PROPN
bibechana-21109	71	35	of	of	ADP
bibechana-21109	71	36	thr	thr	PROPN
bibechana-21109	71	37	-	-	PUNCT
bibechana-21109	71	38	wt	wt	NOUN
bibechana-21109	71	39	,	,	PUNCT
bibechana-21109	71	40	thrt3	thrt3	NOUN
bibechana-21109	71	41	-	-	PUNCT
bibechana-21109	71	42	wt	wt	NOUN
bibechana-21109	71	43	and	and	CCONJ
bibechana-21109	71	44	thrt3	thrt3	PROPN
bibechana-21109	71	45	-	-	PUNCT
bibechana-21109	71	46	mt	mt	PROPN
bibechana-21109	71	47	.	.	PUNCT
bibechana-21109	72	1	the	the	DET
bibechana-21109	72	2	dihedral	dihedral	ADJ
bibechana-21109	72	3	angle	angle	NOUN
bibechana-21109	72	4	distributions	distribution	NOUN
bibechana-21109	72	5	were	be	AUX
bibechana-21109	72	6	analyzed	analyze	VERB
bibechana-21109	72	7	from	from	ADP
bibechana-21109	72	8	ramachandran	ramachandran	PROPN
bibechana-21109	72	9	plots	plot	NOUN
bibechana-21109	72	10	to	to	PART
bibechana-21109	72	11	test	test	VERB
bibechana-21109	72	12	the	the	DET
bibechana-21109	72	13	steric	steric	ADJ
bibechana-21109	72	14	hindrance	hindrance	NOUN
bibechana-21109	72	15	among	among	ADP
bibechana-21109	72	16	α	α	NOUN
bibechana-21109	72	17	-	-	PUNCT
bibechana-21109	72	18	helices	helix	NOUN
bibechana-21109	72	19	,	,	PUNCT
bibechana-21109	72	20	β	β	NOUN
bibechana-21109	72	21	-	-	PUNCT
bibechana-21109	72	22	sheets	sheet	NOUN
bibechana-21109	72	23	and	and	CCONJ
bibechana-21109	72	24	side	side	NOUN
bibechana-21109	72	25	chains	chain	NOUN
bibechana-21109	72	26	and	and	CCONJ
bibechana-21109	72	27	residues	residue	NOUN
bibechana-21109	72	28	of	of	ADP
bibechana-21109	72	29	the	the	DET
bibechana-21109	72	30	systems	system	NOUN
bibechana-21109	72	31	.	.	PUNCT
bibechana-21109	73	1	the	the	DET
bibechana-21109	73	2	electrostatic	electrostatic	ADJ
bibechana-21109	73	3	and	and	CCONJ
bibechana-21109	73	4	van	van	PROPN
bibechana-21109	73	5	der	der	NOUN
bibechana-21109	73	6	waals	waal	NOUN
bibechana-21109	73	7	interactions	interaction	NOUN
bibechana-21109	73	8	were	be	AUX
bibechana-21109	73	9	observed	observe	VERB
bibechana-21109	73	10	between	between	ADP
bibechana-21109	73	11	the	the	DET
bibechana-21109	73	12	native	native	ADJ
bibechana-21109	73	13	or	or	CCONJ
bibechana-21109	73	14	mutated	mutate	VERB
bibechana-21109	73	15	residue	residue	NOUN
bibechana-21109	73	16	on	on	ADP
bibechana-21109	73	17	431	431	NUM
bibechana-21109	73	18	-	-	PUNCT
bibechana-21109	73	19	codon	codon	ADJ
bibechana-21109	73	20	and	and	CCONJ
bibechana-21109	73	21	t3	t3	NOUN
bibechana-21109	73	22	-	-	PUNCT
bibechana-21109	73	23	hormone	hormone	NOUN
bibechana-21109	73	24	by	by	ADP
bibechana-21109	73	25	using	use	VERB
bibechana-21109	73	26	namd	namd	ADJ
bibechana-21109	73	27	-	-	PUNCT
bibechana-21109	73	28	energy	energy	NOUN
bibechana-21109	73	29	-	-	PUNCT
bibechana-21109	73	30	gui	gui	NOUN
bibechana-21109	73	31	.	.	PUNCT
bibechana-21109	74	1	also	also	ADV
bibechana-21109	74	2	,	,	PUNCT
bibechana-21109	74	3	number	number	NOUN
bibechana-21109	74	4	of	of	ADP
bibechana-21109	74	5	h	h	NOUN
bibechana-21109	74	6	-	-	PUNCT
bibechana-21109	74	7	bonding	bonding	NOUN
bibechana-21109	74	8	,	,	PUNCT
bibechana-21109	74	9	probability	probability	NOUN
bibechana-21109	74	10	density	density	NOUN
bibechana-21109	74	11	from	from	ADP
bibechana-21109	74	12	radial	radial	ADJ
bibechana-21109	74	13	distribution	distribution	NOUN
bibechana-21109	74	14	functions	function	NOUN
bibechana-21109	74	15	,	,	PUNCT
bibechana-21109	74	16	ir	ir	PROPN
bibechana-21109	74	17	spectral	spectral	ADJ
bibechana-21109	74	18	densities	density	NOUN
bibechana-21109	74	19	,	,	PUNCT
bibechana-21109	74	20	internal	internal	ADJ
bibechana-21109	74	21	energies	energy	NOUN
bibechana-21109	74	22	of	of	ADP
bibechana-21109	74	23	the	the	DET
bibechana-21109	74	24	native	native	ADJ
bibechana-21109	74	25	wild	wild	ADJ
bibechana-21109	74	26	type	type	NOUN
bibechana-21109	74	27	and	and	CCONJ
bibechana-21109	74	28	mutated	mutate	VERB
bibechana-21109	74	29	systems	system	NOUN
bibechana-21109	74	30	were	be	AUX
bibechana-21109	74	31	calculated	calculate	VERB
bibechana-21109	74	32	,	,	PUNCT
bibechana-21109	74	33	analyzed	analyze	VERB
bibechana-21109	74	34	and	and	CCONJ
bibechana-21109	74	35	compared	compare	VERB
bibechana-21109	74	36	by	by	ADP
bibechana-21109	74	37	plotting	plot	VERB
bibechana-21109	74	38	the	the	DET
bibechana-21109	74	39	corresponding	corresponding	ADJ
bibechana-21109	74	40	results	result	NOUN
bibechana-21109	74	41	over	over	ADP
bibechana-21109	74	42	the	the	DET
bibechana-21109	74	43	simulation	simulation	NOUN
bibechana-21109	74	44	time	time	NOUN
bibechana-21109	74	45	.	.	PUNCT
bibechana-21109	75	1	3	3	X
bibechana-21109	75	2	.	.	NOUN
bibechana-21109	75	3	result	result	NOUN
bibechana-21109	75	4	and	and	CCONJ
bibechana-21109	75	5	discussion	discussion	NOUN
bibechana-21109	75	6	thr	thr	PROPN
bibechana-21109	75	7	-	-	PUNCT
bibechana-21109	75	8	β	β	X
bibechana-21109	75	9	nuclear	nuclear	ADJ
bibechana-21109	75	10	receptor	receptor	NOUN
bibechana-21109	75	11	isoform	isoform	NOUN
bibechana-21109	75	12	consists	consist	VERB
bibechana-21109	75	13	of	of	ADP
bibechana-21109	75	14	a	a	DET
bibechana-21109	75	15	chain	chain	NOUN
bibechana-21109	75	16	length	length	NOUN
bibechana-21109	75	17	of	of	ADP
bibechana-21109	75	18	259	259	NUM
bibechana-21109	75	19	amino	amino	NOUN
bibechana-21109	75	20	acid	acid	NOUN
bibechana-21109	75	21	residues	residue	NOUN
bibechana-21109	75	22	.	.	PUNCT
bibechana-21109	76	1	the	the	DET
bibechana-21109	76	2	protein	protein	NOUN
bibechana-21109	76	3	structure	structure	NOUN
bibechana-21109	76	4	of	of	ADP
bibechana-21109	76	5	wild	wild	ADJ
bibechana-21109	76	6	type	type	NOUN
bibechana-21109	76	7	thr	thr	PROPN
bibechana-21109	76	8	-	-	PUNCT
bibechana-21109	76	9	β	β	NOUN
bibechana-21109	76	10	that	that	SCONJ
bibechana-21109	76	11	we	we	PRON
bibechana-21109	76	12	take	take	VERB
bibechana-21109	76	13	for	for	ADP
bibechana-21109	76	14	the	the	DET
bibechana-21109	76	15	simulation	simulation	NOUN
bibechana-21109	76	16	has	have	VERB
bibechana-21109	76	17	total	total	ADJ
bibechana-21109	76	18	mass	mass	NOUN
bibechana-21109	76	19	of	of	ADP
bibechana-21109	76	20	27640	27640	NUM
bibechana-21109	76	21	amu	amu	NOUN
bibechana-21109	76	22	and	and	CCONJ
bibechana-21109	76	23	3895	3895	NUM
bibechana-21109	76	24	atoms	atom	NOUN
bibechana-21109	76	25	.	.	PUNCT
bibechana-21109	77	1	the	the	DET
bibechana-21109	77	2	active	active	ADJ
bibechana-21109	77	3	ligand	ligand	NOUN
bibechana-21109	77	4	bound	bind	VERB
bibechana-21109	77	5	to	to	ADP
bibechana-21109	77	6	the	the	DET
bibechana-21109	77	7	lbd	lbd	PROPN
bibechana-21109	77	8	of	of	ADP
bibechana-21109	77	9	thr	thr	PROPN
bibechana-21109	77	10	-	-	PUNCT
bibechana-21109	77	11	β	β	PROPN
bibechana-21109	77	12	is	be	AUX
bibechana-21109	77	13	the	the	DET
bibechana-21109	77	14	thyroid	thyroid	NOUN
bibechana-21109	77	15	hormone	hormone	NOUN
bibechana-21109	77	16	(	(	PUNCT
bibechana-21109	77	17	t3	t3	PROPN
bibechana-21109	77	18	)	)	PUNCT
bibechana-21109	77	19	which	which	PRON
bibechana-21109	77	20	has	have	VERB
bibechana-21109	77	21	mass	mass	NOUN
bibechana-21109	77	22	of	of	ADP
bibechana-21109	77	23	651	651	NUM
bibechana-21109	77	24	amu	amu	NOUN
bibechana-21109	77	25	and	and	CCONJ
bibechana-21109	77	26	35	35	NUM
bibechana-21109	77	27	atoms	atom	NOUN
bibechana-21109	77	28	.	.	PUNCT
bibechana-21109	78	1	the	the	DET
bibechana-21109	78	2	plots	plot	NOUN
bibechana-21109	78	3	of	of	ADP
bibechana-21109	78	4	dihedral	dihedral	ADJ
bibechana-21109	78	5	angles	angle	NOUN
bibechana-21109	78	6	(	(	PUNCT
bibechana-21109	78	7	φ	φ	NOUN
bibechana-21109	78	8	,	,	PUNCT
bibechana-21109	78	9	ψ	ψ	NOUN
bibechana-21109	78	10	)	)	PUNCT
bibechana-21109	78	11	,	,	PUNCT
bibechana-21109	78	12	i.	i.	PROPN
bibechana-21109	78	13	e.	e.	PROPN
bibechana-21109	78	14	ramachandran	ramachandran	PROPN
bibechana-21109	78	15	plots	plot	VERB
bibechana-21109	78	16	for	for	ADP
bibechana-21109	78	17	thr	thr	PROPN
bibechana-21109	78	18	-	-	PUNCT
bibechana-21109	78	19	wt	wt	NOUN
bibechana-21109	78	20	,	,	PUNCT
bibechana-21109	78	21	thrt3	thrt3	NOUN
bibechana-21109	78	22	-	-	PUNCT
bibechana-21109	78	23	wt	wt	NOUN
bibechana-21109	78	24	and	and	CCONJ
bibechana-21109	78	25	i431v	i431v	PROPN
bibechana-21109	78	26	mutant	mutant	ADJ
bibechana-21109	78	27	thrt3	thrt3	PROPN
bibechana-21109	78	28	-	-	PUNCT
bibechana-21109	78	29	mt	mt	PROPN
bibechana-21109	78	30	are	be	AUX
bibechana-21109	78	31	shown	show	VERB
bibechana-21109	78	32	in	in	ADP
bibechana-21109	78	33	fig	fig	NOUN
bibechana-21109	78	34	.	.	PUNCT
bibechana-21109	79	1	3	3	X
bibechana-21109	79	2	.	.	X
bibechana-21109	80	1	in	in	ADP
bibechana-21109	80	2	these	these	DET
bibechana-21109	80	3	plots	plot	NOUN
bibechana-21109	80	4	,	,	PUNCT
bibechana-21109	80	5	most	most	ADJ
bibechana-21109	80	6	of	of	ADP
bibechana-21109	80	7	the	the	DET
bibechana-21109	80	8	amino	amino	NOUN
bibechana-21109	80	9	acid	acid	NOUN
bibechana-21109	80	10	residues	residue	NOUN
bibechana-21109	80	11	of	of	ADP
bibechana-21109	80	12	parallel	parallel	ADJ
bibechana-21109	80	13	,	,	PUNCT
bibechana-21109	80	14	anti	anti	ADJ
bibechana-21109	80	15	-	-	ADJ
bibechana-21109	80	16	parallel	parallel	ADJ
bibechana-21109	80	17	and	and	CCONJ
bibechana-21109	80	18	right	right	ADJ
bibechana-21109	80	19	twisted	twisted	ADJ
bibechana-21109	80	20	β	β	NOUN
bibechana-21109	80	21	-	-	NOUN
bibechana-21109	80	22	sheets	sheet	NOUN
bibechana-21109	80	23	lie	lie	VERB
bibechana-21109	80	24	in	in	ADP
bibechana-21109	80	25	the	the	DET
bibechana-21109	80	26	blue	blue	ADJ
bibechana-21109	80	27	region	region	NOUN
bibechana-21109	80	28	of	of	ADP
bibechana-21109	80	29	i	i	PROPN
bibechana-21109	80	30	-	-	PUNCT
bibechana-21109	80	31	quadrant	quadrant	NOUN
bibechana-21109	80	32	;	;	PUNCT
bibechana-21109	80	33	that	that	PRON
bibechana-21109	80	34	of	of	ADP
bibechana-21109	80	35	right	right	ADJ
bibechana-21109	80	36	handed	handed	ADJ
bibechana-21109	80	37	α	α	NOUN
bibechana-21109	80	38	-	-	PUNCT
bibechana-21109	80	39	helix	helix	ADJ
bibechana-21109	80	40	lie	lie	NOUN
bibechana-21109	80	41	in	in	ADP
bibechana-21109	80	42	the	the	DET
bibechana-21109	80	43	blue	blue	ADJ
bibechana-21109	80	44	region	region	NOUN
bibechana-21109	80	45	of	of	ADP
bibechana-21109	80	46	ii	ii	NOUN
bibechana-21109	80	47	-	-	PUNCT
bibechana-21109	80	48	quadrant	quadrant	NOUN
bibechana-21109	80	49	and	and	CCONJ
bibechana-21109	80	50	left	leave	VERB
bibechana-21109	80	51	handed	hand	VERB
bibechana-21109	80	52	α	α	PRON
bibechana-21109	80	53	-	-	PUNCT
bibechana-21109	80	54	helix	helix	ADJ
bibechana-21109	80	55	lie	lie	NOUN
bibechana-21109	80	56	in	in	ADP
bibechana-21109	80	57	the	the	DET
bibechana-21109	80	58	green	green	ADJ
bibechana-21109	80	59	region	region	NOUN
bibechana-21109	80	60	of	of	ADP
bibechana-21109	80	61	iii	iii	NOUN
bibechana-21109	80	62	-	-	NOUN
bibechana-21109	80	63	quadrant	quadrant	NOUN
bibechana-21109	80	64	[	[	X
bibechana-21109	80	65	26	26	NUM
bibechana-21109	80	66	,	,	PUNCT
bibechana-21109	80	67	27	27	NUM
bibechana-21109	80	68	]	]	PUNCT
bibechana-21109	80	69	.	.	PUNCT
bibechana-21109	81	1	the	the	DET
bibechana-21109	81	2	residue	residue	NOUN
bibechana-21109	81	3	gly	gly	NOUN
bibechana-21109	81	4	has	have	VERB
bibechana-21109	81	5	no	no	DET
bibechana-21109	81	6	side	side	NOUN
bibechana-21109	81	7	chain	chain	NOUN
bibechana-21109	81	8	so	so	SCONJ
bibechana-21109	81	9	that	that	SCONJ
bibechana-21109	81	10	it	it	PRON
bibechana-21109	81	11	has	have	VERB
bibechana-21109	81	12	no	no	DET
bibechana-21109	81	13	steric	steric	ADJ
bibechana-21109	81	14	hindrance	hindrance	NOUN
bibechana-21109	81	15	and	and	CCONJ
bibechana-21109	81	16	it	it	PRON
bibechana-21109	81	17	is	be	AUX
bibechana-21109	81	18	allowed	allow	VERB
bibechana-21109	81	19	in	in	ADP
bibechana-21109	81	20	the	the	DET
bibechana-21109	81	21	white	white	PROPN
bibechana-21109	81	22	region	region	NOUN
bibechana-21109	81	23	.	.	PUNCT
bibechana-21109	82	1	the	the	DET
bibechana-21109	82	2	white	white	PROPN
bibechana-21109	82	3	region	region	NOUN
bibechana-21109	82	4	is	be	AUX
bibechana-21109	82	5	sterically	sterically	ADV
bibechana-21109	82	6	disallowed	disallow	VERB
bibechana-21109	82	7	for	for	ADP
bibechana-21109	82	8	all	all	DET
bibechana-21109	82	9	other	other	ADJ
bibechana-21109	82	10	amino	amino	ADJ
bibechana-21109	82	11	acids	acid	NOUN
bibechana-21109	82	12	except	except	SCONJ
bibechana-21109	82	13	gly	gly	NOUN
bibechana-21109	82	14	.	.	PUNCT
bibechana-21109	83	1	the	the	DET
bibechana-21109	83	2	blue	blue	ADJ
bibechana-21109	83	3	regions	region	NOUN
bibechana-21109	83	4	are	be	AUX
bibechana-21109	83	5	the	the	DET
bibechana-21109	83	6	most	most	ADV
bibechana-21109	83	7	allowed	allow	VERB
bibechana-21109	83	8	regions	region	NOUN
bibechana-21109	83	9	for	for	ADP
bibechana-21109	83	10	α	α	NOUN
bibechana-21109	83	11	-	-	PUNCT
bibechana-21109	83	12	helices	helix	NOUN
bibechana-21109	83	13	and	and	CCONJ
bibechana-21109	83	14	β	β	NOUN
bibechana-21109	83	15	-	-	NOUN
bibechana-21109	83	16	sheets	sheet	NOUN
bibechana-21109	83	17	.	.	PUNCT
bibechana-21109	84	1	the	the	DET
bibechana-21109	84	2	green	green	ADJ
bibechana-21109	84	3	area	area	NOUN
bibechana-21109	84	4	is	be	AUX
bibechana-21109	84	5	allowed	allow	VERB
bibechana-21109	84	6	for	for	ADP
bibechana-21109	84	7	the	the	DET
bibechana-21109	84	8	shorter	short	ADJ
bibechana-21109	84	9	van	van	PROPN
bibechana-21109	84	10	der	der	PROPN
bibechana-21109	84	11	waal	waal	PROPN
bibechana-21109	84	12	radii	radius	NOUN
bibechana-21109	84	13	of	of	ADP
bibechana-21109	84	14	atoms	atom	NOUN
bibechana-21109	84	15	and	and	CCONJ
bibechana-21109	84	16	the	the	DET
bibechana-21109	84	17	related	related	ADJ
bibechana-21109	84	18	amino	amino	NOUN
bibechana-21109	84	19	acids	acid	NOUN
bibechana-21109	84	20	.	.	PUNCT
bibechana-21109	85	1	by	by	ADP
bibechana-21109	85	2	comparing	compare	VERB
bibechana-21109	85	3	three	three	NUM
bibechana-21109	85	4	plots	plot	NOUN
bibechana-21109	85	5	of	of	ADP
bibechana-21109	85	6	fig	fig	NOUN
bibechana-21109	85	7	.	.	PUNCT
bibechana-21109	86	1	2	2	NUM
bibechana-21109	86	2	,	,	PUNCT
bibechana-21109	86	3	we	we	PRON
bibechana-21109	86	4	observe	observe	VERB
bibechana-21109	86	5	that	that	SCONJ
bibechana-21109	86	6	smaller	small	ADJ
bibechana-21109	86	7	number	number	NOUN
bibechana-21109	86	8	of	of	ADP
bibechana-21109	86	9	amino	amino	NOUN
bibechana-21109	86	10	acid	acid	NOUN
bibechana-21109	86	11	residues	residue	NOUN
bibechana-21109	86	12	lies	lie	VERB
bibechana-21109	86	13	in	in	ADP
bibechana-21109	86	14	the	the	DET
bibechana-21109	86	15	disallowed	disallow	VERB
bibechana-21109	86	16	region	region	NOUN
bibechana-21109	86	17	for	for	ADP
bibechana-21109	86	18	thrt3	thrt3	NOUN
bibechana-21109	86	19	-	-	PUNCT
bibechana-21109	86	20	wt	wt	NOUN
bibechana-21109	86	21	than	than	ADP
bibechana-21109	86	22	for	for	ADP
bibechana-21109	86	23	thr	thr	PROPN
bibechana-21109	86	24	-	-	PUNCT
bibechana-21109	86	25	wt	wt	NOUN
bibechana-21109	86	26	and	and	CCONJ
bibechana-21109	86	27	thrt3	thrt3	PROPN
bibechana-21109	86	28	-	-	PUNCT
bibechana-21109	86	29	i431v	i431v	PROPN
bibechana-21109	86	30	.	.	PUNCT
bibechana-21109	87	1	thus	thus	ADV
bibechana-21109	87	2	,	,	PUNCT
bibechana-21109	87	3	the	the	DET
bibechana-21109	87	4	larger	large	ADJ
bibechana-21109	87	5	steric	steric	ADJ
bibechana-21109	87	6	hindrances	hindrance	NOUN
bibechana-21109	87	7	occur	occur	VERB
bibechana-21109	87	8	for	for	ADP
bibechana-21109	87	9	the	the	DET
bibechana-21109	87	10	unliganded	unligande	VERB
bibechana-21109	87	11	and	and	CCONJ
bibechana-21109	87	12	mutated	mutate	VERB
bibechana-21109	87	13	thr	thr	PROPN
bibechana-21109	87	14	-	-	PUNCT
bibechana-21109	87	15	β	β	NOUN
bibechana-21109	87	16	.	.	PUNCT
bibechana-21109	88	1	the	the	DET
bibechana-21109	88	2	clinical	clinical	ADJ
bibechana-21109	88	3	analysis	analysis	NOUN
bibechana-21109	88	4	shows	show	VERB
bibechana-21109	88	5	that	that	SCONJ
bibechana-21109	88	6	thrt3	thrt3	PROPN
bibechana-21109	88	7	-	-	PUNCT
bibechana-21109	88	8	wt	wt	PROPN
bibechana-21109	88	9	is	be	AUX
bibechana-21109	88	10	related	relate	VERB
bibechana-21109	88	11	to	to	PART
bibechana-21109	88	12	euthyroid	euthyroid	VERB
bibechana-21109	88	13	or	or	CCONJ
bibechana-21109	88	14	normal	normal	ADJ
bibechana-21109	88	15	thyroid	thyroid	NOUN
bibechana-21109	88	16	functions	function	NOUN
bibechana-21109	88	17	,	,	PUNCT
bibechana-21109	88	18	thr	thr	PROPN
bibechana-21109	88	19	-	-	PUNCT
bibechana-21109	88	20	wt	wt	PROPN
bibechana-21109	88	21	is	be	AUX
bibechana-21109	88	22	related	relate	VERB
bibechana-21109	88	23	to	to	ADP
bibechana-21109	88	24	overt	overt	ADJ
bibechana-21109	88	25	thyroidism	thyroidism	NOUN
bibechana-21109	88	26	and	and	CCONJ
bibechana-21109	88	27	thrt3	thrt3	PROPN
bibechana-21109	88	28	-	-	PUNCT
bibechana-21109	88	29	mt	mt	PROPN
bibechana-21109	88	30	is	be	AUX
bibechana-21109	88	31	related	relate	VERB
bibechana-21109	88	32	to	to	ADP
bibechana-21109	88	33	rth	rth	VERB
bibechana-21109	88	34	[	[	X
bibechana-21109	88	35	6	6	NUM
bibechana-21109	88	36	-	-	SYM
bibechana-21109	88	37	14	14	NUM
bibechana-21109	88	38	]	]	PUNCT
bibechana-21109	88	39	.	.	PUNCT
bibechana-21109	89	1	012345678	012345678	NUM
bibechana-21109	89	2	0	0	NUM
bibechana-21109	90	1	1000	1000	NUM
bibechana-21109	90	2	2000	2000	NUM
bibechana-21109	90	3	3000	3000	NUM
bibechana-21109	90	4	4000rmsd	4000rmsd	NOUN
bibechana-21109	90	5	(	(	PUNCT
bibechana-21109	90	6	å	å	NOUN
bibechana-21109	90	7	)	)	PUNCT
bibechana-21109	90	8	time	time	NOUN
bibechana-21109	90	9	frame	frame	NOUN
bibechana-21109	90	10	(	(	PUNCT
bibechana-21109	90	11	0.5ps	0.5ps	NOUN
bibechana-21109	90	12	/	/	SYM
bibechana-21109	90	13	frame)i431	frame)i431	NOUN
bibechana-21109	90	14	thr	thr	NOUN
bibechana-21109	90	15	-	-	PUNCT
bibechana-21109	90	16	protein	protein	NOUN
bibechana-21109	90	17	t3024681012	t3024681012	NOUN
bibechana-21109	90	18	0	0	NUM
bibechana-21109	90	19	1000	1000	NUM
bibechana-21109	90	20	2000	2000	NUM
bibechana-21109	90	21	3000	3000	NUM
bibechana-21109	90	22	4000rmsd(å	4000rmsd(å	NUM
bibechana-21109	90	23	)	)	PUNCT
bibechana-21109	90	24	time	time	NOUN
bibechana-21109	90	25	frame	frame	NOUN
bibechana-21109	90	26	(	(	PUNCT
bibechana-21109	90	27	0.5ps	0.5ps	PROPN
bibechana-21109	90	28	/	/	SYM
bibechana-21109	90	29	frame)thr	frame)thr	NOUN
bibechana-21109	90	30	-	-	PUNCT
bibechana-21109	90	31	protein	protein	NOUN
bibechana-21109	90	32	i431	i431	PROPN
bibechana-21109	90	33	0123456789	0123456789	NUM
bibechana-21109	90	34	0	0	NUM
bibechana-21109	90	35	1000	1000	NUM
bibechana-21109	90	36	2000	2000	NUM
bibechana-21109	90	37	3000	3000	NUM
bibechana-21109	90	38	4000rmsd	4000rmsd	NOUN
bibechana-21109	90	39	(	(	PUNCT
bibechana-21109	90	40	å	å	NOUN
bibechana-21109	90	41	)	)	PUNCT
bibechana-21109	90	42	time	time	NOUN
bibechana-21109	90	43	frame	frame	NOUN
bibechana-21109	90	44	(	(	PUNCT
bibechana-21109	90	45	0.5ps	0.5ps	PROPN
bibechana-21109	90	46	/	/	SYM
bibechana-21109	90	47	frame)thr	frame)thr	NOUN
bibechana-21109	90	48	-	-	PUNCT
bibechana-21109	90	49	protein	protein	NOUN
bibechana-21109	90	50	i431v	i431v	PROPN
bibechana-21109	90	51	t3	t3	NOUN
bibechana-21109	90	52	tika	tika	X
bibechana-21109	90	53	ram	ram	NOUN
bibechana-21109	90	54	lamichhane	lamichhane	NOUN
bibechana-21109	90	55	et	et	PROPN
bibechana-21109	90	56	al./	al./	ADV
bibechana-21109	90	57	bibechana	bibechana	PROPN
bibechana-21109	90	58	16	16	NUM
bibechana-21109	90	59	(	(	PUNCT
bibechana-21109	90	60	2019	2019	NUM
bibechana-21109	90	61	)	)	PUNCT
bibechana-21109	90	62	79	79	NUM
bibechana-21109	90	63	-	-	SYM
bibechana-21109	90	64	91	91	NUM
bibechana-21109	90	65	:	:	PUNCT
bibechana-21109	90	66	rcost	rcost	NOUN
bibechana-21109	90	67	p.83	p.83	PROPN
bibechana-21109	90	68	(	(	PUNCT
bibechana-21109	90	69	online	online	ADJ
bibechana-21109	90	70	publication	publication	NOUN
bibechana-21109	90	71	:	:	PUNCT
bibechana-21109	90	72	dec	dec	PROPN
bibechana-21109	90	73	.	.	PROPN
bibechana-21109	90	74	,	,	PUNCT
bibechana-21109	90	75	2018	2018	NUM
bibechana-21109	90	76	)	)	PUNCT
bibechana-21109	90	77	fig	fig	NOUN
bibechana-21109	90	78	.	.	PUNCT
bibechana-21109	91	1	3	3	NUM
bibechana-21109	91	2	:	:	PUNCT
bibechana-21109	91	3	ramachandran	ramachandran	NOUN
bibechana-21109	91	4	plots	plot	VERB
bibechana-21109	91	5	for	for	ADP
bibechana-21109	91	6	(	(	PUNCT
bibechana-21109	91	7	a	a	DET
bibechana-21109	91	8	)	)	PUNCT
bibechana-21109	91	9	wild	wild	ADJ
bibechana-21109	91	10	type	type	NOUN
bibechana-21109	91	11	thr	thr	PROPN
bibechana-21109	91	12	-	-	PUNCT
bibechana-21109	91	13	β	β	NOUN
bibechana-21109	91	14	,	,	PUNCT
bibechana-21109	91	15	(	(	PUNCT
bibechana-21109	91	16	b	b	NOUN
bibechana-21109	91	17	)	)	PUNCT
bibechana-21109	91	18	t3	t3	NOUN
bibechana-21109	91	19	-	-	PUNCT
bibechana-21109	91	20	liganded	ligande	VERB
bibechana-21109	91	21	wild	wild	ADJ
bibechana-21109	91	22	type	type	NOUN
bibechana-21109	91	23	thr	thr	PROPN
bibechana-21109	91	24	-	-	PUNCT
bibechana-21109	91	25	β	β	X
bibechana-21109	91	26	and	and	CCONJ
bibechana-21109	91	27	(	(	PUNCT
bibechana-21109	91	28	c	c	X
bibechana-21109	91	29	)	)	PUNCT
bibechana-21109	91	30	i431v	i431v	PROPN
bibechana-21109	91	31	-	-	PUNCT
bibechana-21109	91	32	mutant	mutant	NOUN
bibechana-21109	91	33	thrt3	thrt3	PROPN
bibechana-21109	91	34	.	.	PUNCT
bibechana-21109	92	1	the	the	DET
bibechana-21109	92	2	constancy	constancy	NOUN
bibechana-21109	92	3	of	of	ADP
bibechana-21109	92	4	root	root	NOUN
bibechana-21109	92	5	mean	mean	ADJ
bibechana-21109	92	6	square	square	ADJ
bibechana-21109	92	7	deviation	deviation	NOUN
bibechana-21109	92	8	(	(	PUNCT
bibechana-21109	92	9	rmsd	rmsd	NOUN
bibechana-21109	92	10	)	)	PUNCT
bibechana-21109	92	11	and	and	CCONJ
bibechana-21109	92	12	radius	radius	NOUN
bibechana-21109	92	13	of	of	ADP
bibechana-21109	92	14	gyration	gyration	NOUN
bibechana-21109	92	15	(	(	PUNCT
bibechana-21109	92	16	rg	rg	NOUN
bibechana-21109	92	17	)	)	PUNCT
bibechana-21109	92	18	of	of	ADP
bibechana-21109	92	19	the	the	DET
bibechana-21109	92	20	molecules	molecule	NOUN
bibechana-21109	92	21	thr	thr	PROPN
bibechana-21109	92	22	-	-	PUNCT
bibechana-21109	92	23	β	β	NOUN
bibechana-21109	92	24	protein	protein	NOUN
bibechana-21109	92	25	and	and	CCONJ
bibechana-21109	92	26	t3	t3	NOUN
bibechana-21109	92	27	-	-	PUNCT
bibechana-21109	92	28	hormone	hormone	NOUN
bibechana-21109	92	29	over	over	ADP
bibechana-21109	92	30	the	the	DET
bibechana-21109	92	31	time	time	NOUN
bibechana-21109	92	32	frames	frame	NOUN
bibechana-21109	92	33	of	of	ADP
bibechana-21109	92	34	equilibration	equilibration	NOUN
bibechana-21109	92	35	run	run	NOUN
bibechana-21109	92	36	(	(	PUNCT
bibechana-21109	92	37	fig	fig	NOUN
bibechana-21109	92	38	.	.	PUNCT
bibechana-21109	93	1	4	4	NUM
bibechana-21109	93	2	,	,	PUNCT
bibechana-21109	93	3	5	5	X
bibechana-21109	93	4	)	)	PUNCT
bibechana-21109	93	5	show	show	VERB
bibechana-21109	93	6	the	the	DET
bibechana-21109	93	7	conformational	conformational	ADJ
bibechana-21109	93	8	stability	stability	NOUN
bibechana-21109	93	9	and	and	CCONJ
bibechana-21109	93	10	validity	validity	NOUN
bibechana-21109	93	11	of	of	ADP
bibechana-21109	93	12	force	force	NOUN
bibechana-21109	93	13	field	field	NOUN
bibechana-21109	93	14	topology	topology	NOUN
bibechana-21109	93	15	and	and	CCONJ
bibechana-21109	93	16	parameters	parameter	NOUN
bibechana-21109	93	17	used	use	VERB
bibechana-21109	93	18	for	for	ADP
bibechana-21109	93	19	mds	mds	PROPN
bibechana-21109	93	20	of	of	ADP
bibechana-21109	93	21	wild	wild	ADJ
bibechana-21109	93	22	type	type	NOUN
bibechana-21109	93	23	and	and	CCONJ
bibechana-21109	93	24	mutated	mutate	VERB
bibechana-21109	93	25	nuclear	nuclear	ADJ
bibechana-21109	93	26	receptors	receptor	NOUN
bibechana-21109	93	27	.	.	PUNCT
bibechana-21109	94	1	the	the	DET
bibechana-21109	94	2	more	more	ADV
bibechana-21109	94	3	fluctuating	fluctuate	VERB
bibechana-21109	94	4	rmsd	rmsd	NOUN
bibechana-21109	94	5	and	and	CCONJ
bibechana-21109	94	6	rg	rg	PROPN
bibechana-21109	94	7	of	of	ADP
bibechana-21109	94	8	residue	residue	NOUN
bibechana-21109	94	9	id-431	id-431	PROPN
bibechana-21109	94	10	show	show	VERB
bibechana-21109	94	11	its	its	PRON
bibechana-21109	94	12	dynamic	dynamic	ADJ
bibechana-21109	94	13	property	property	NOUN
bibechana-21109	94	14	.	.	PUNCT
bibechana-21109	95	1	this	this	DET
bibechana-21109	95	2	dynamic	dynamic	ADJ
bibechana-21109	95	3	property	property	NOUN
bibechana-21109	95	4	of	of	ADP
bibechana-21109	95	5	the	the	DET
bibechana-21109	95	6	residues	residue	NOUN
bibechana-21109	95	7	is	be	AUX
bibechana-21109	95	8	significantly	significantly	ADV
bibechana-21109	95	9	important	important	ADJ
bibechana-21109	95	10	while	while	SCONJ
bibechana-21109	95	11	trapping	trap	VERB
bibechana-21109	95	12	t3	t3	NOUN
bibechana-21109	95	13	in	in	ADP
bibechana-21109	95	14	and	and	CCONJ
bibechana-21109	95	15	releasing	release	VERB
bibechana-21109	95	16	t3	t3	NOUN
bibechana-21109	95	17	from	from	ADP
bibechana-21109	95	18	the	the	DET
bibechana-21109	95	19	lbd	lbd	PROPN
bibechana-21109	95	20	of	of	ADP
bibechana-21109	95	21	thyroid	thyroid	NOUN
bibechana-21109	95	22	hormone	hormone	NOUN
bibechana-21109	95	23	receptors	receptor	NOUN
bibechana-21109	95	24	.	.	PUNCT
bibechana-21109	96	1	(	(	PUNCT
bibechana-21109	96	2	a	a	X
bibechana-21109	96	3	)	)	PUNCT
bibechana-21109	96	4	(	(	PUNCT
bibechana-21109	96	5	b	b	X
bibechana-21109	96	6	)	)	PUNCT
bibechana-21109	96	7	(	(	PUNCT
bibechana-21109	96	8	c	c	X
bibechana-21109	96	9	)	)	PUNCT
bibechana-21109	96	10	fig.4	fig.4	PROPN
bibechana-21109	96	11	:	:	PUNCT
bibechana-21109	96	12	rmsd	rmsd	NOUN
bibechana-21109	96	13	-	-	PUNCT
bibechana-21109	96	14	plots	plot	NOUN
bibechana-21109	96	15	of	of	ADP
bibechana-21109	96	16	431	431	NUM
bibechana-21109	96	17	residue	residue	NOUN
bibechana-21109	96	18	,	,	PUNCT
bibechana-21109	96	19	thr	thr	NOUN
bibechana-21109	96	20	-	-	PUNCT
bibechana-21109	96	21	protein	protein	NOUN
bibechana-21109	96	22	and	and	CCONJ
bibechana-21109	96	23	t3	t3	NOUN
bibechana-21109	96	24	-	-	PUNCT
bibechana-21109	96	25	hormone	hormone	NOUN
bibechana-21109	96	26	during	during	ADP
bibechana-21109	96	27	equilibration	equilibration	NOUN
bibechana-21109	96	28	of	of	ADP
bibechana-21109	96	29	(	(	PUNCT
bibechana-21109	96	30	a	a	X
bibechana-21109	96	31	)	)	PUNCT
bibechana-21109	96	32	wild	wild	ADJ
bibechana-21109	96	33	type	type	NOUN
bibechana-21109	96	34	thr	thr	PROPN
bibechana-21109	96	35	,	,	PUNCT
bibechana-21109	96	36	(	(	PUNCT
bibechana-21109	96	37	b	b	X
bibechana-21109	96	38	)	)	PUNCT
bibechana-21109	96	39	wild	wild	ADJ
bibechana-21109	96	40	type	type	NOUN
bibechana-21109	96	41	thrt3	thrt3	PROPN
bibechana-21109	97	1	and	and	CCONJ
bibechana-21109	97	2	(	(	PUNCT
bibechana-21109	97	3	c	c	X
bibechana-21109	97	4	)	)	PUNCT
bibechana-21109	97	5	i431v	i431v	PROPN
bibechana-21109	97	6	-	-	PUNCT
bibechana-21109	97	7	mutant	mutant	NOUN
bibechana-21109	97	8	thrt3	thrt3	PROPN
bibechana-21109	97	9	.	.	PUNCT
bibechana-21109	98	1	the	the	DET
bibechana-21109	98	2	values	value	NOUN
bibechana-21109	98	3	of	of	ADP
bibechana-21109	98	4	rmsd	rmsd	NOUN
bibechana-21109	98	5	and	and	CCONJ
bibechana-21109	98	6	rg	rg	PROPN
bibechana-21109	98	7	of	of	ADP
bibechana-21109	98	8	the	the	DET
bibechana-21109	98	9	molecules	molecule	NOUN
bibechana-21109	98	10	with	with	ADP
bibechana-21109	98	11	the	the	DET
bibechana-21109	98	12	standard	standard	ADJ
bibechana-21109	98	13	deviations	deviation	NOUN
bibechana-21109	98	14	of	of	ADP
bibechana-21109	98	15	the	the	DET
bibechana-21109	98	16	data	datum	NOUN
bibechana-21109	98	17	are	be	AUX
bibechana-21109	98	18	listed	list	VERB
bibechana-21109	98	19	in	in	ADP
bibechana-21109	98	20	the	the	DET
bibechana-21109	98	21	table	table	NOUN
bibechana-21109	98	22	1	1	NUM
bibechana-21109	98	23	.	.	PUNCT
bibechana-21109	99	1	during	during	ADP
bibechana-21109	99	2	their	their	PRON
bibechana-21109	99	3	2	2	NUM
bibechana-21109	99	4	ns	ns	NUM
bibechana-21109	99	5	equilibration	equilibration	NOUN
bibechana-21109	99	6	run	run	VERB
bibechana-21109	99	7	in	in	ADP
bibechana-21109	99	8	neutral	neutral	ADJ
bibechana-21109	99	9	water	water	NOUN
bibechana-21109	99	10	-	-	PUNCT
bibechana-21109	99	11	ion	ion	NOUN
bibechana-21109	99	12	environment	environment	NOUN
bibechana-21109	99	13	,	,	PUNCT
bibechana-21109	99	14	rg	rg	X
bibechana-21109	99	15	of	of	ADP
bibechana-21109	99	16	431	431	NUM
bibechana-21109	99	17	-	-	PUNCT
bibechana-21109	99	18	residue	residue	NOUN
bibechana-21109	99	19	of	of	ADP
bibechana-21109	99	20	thr	thr	PROPN
bibechana-21109	99	21	-	-	PUNCT
bibechana-21109	99	22	wt	wt	PROPN
bibechana-21109	99	23	is	be	AUX
bibechana-21109	99	24	being	be	AUX
bibechana-21109	99	25	smaller	small	ADJ
bibechana-21109	99	26	with	with	ADP
bibechana-21109	99	27	larger	large	ADJ
bibechana-21109	99	28	rmsd	rmsd	NOUN
bibechana-21109	99	29	,	,	PUNCT
bibechana-21109	99	30	i.e.	i.e.	X
bibechana-21109	99	31	it	it	PRON
bibechana-21109	99	32	is	be	AUX
bibechana-21109	99	33	bending	bend	VERB
bibechana-21109	99	34	more	more	ADJ
bibechana-21109	99	35	towards	towards	ADP
bibechana-21109	99	36	the	the	DET
bibechana-21109	99	37	center	center	NOUN
bibechana-21109	99	38	of	of	ADP
bibechana-21109	99	39	mass	mass	NOUN
bibechana-21109	99	40	of	of	ADP
bibechana-21109	99	41	the	the	DET
bibechana-21109	99	42	system	system	NOUN
bibechana-21109	99	43	than	than	ADP
bibechana-21109	99	44	that	that	PRON
bibechana-21109	99	45	of	of	ADP
bibechana-21109	99	46	thrt3	thrt3	PROPN
bibechana-21109	99	47	-	-	PUNCT
bibechana-21109	99	48	wt	wt	NOUN
bibechana-21109	99	49	and	and	CCONJ
bibechana-21109	99	50	thrt3	thrt3	PROPN
bibechana-21109	99	51	-	-	PUNCT
bibechana-21109	99	52	mt	mt	PROPN
bibechana-21109	99	53	.	.	PROPN
bibechana-21109	100	1	in	in	ADP
bibechana-21109	100	2	other	other	ADJ
bibechana-21109	100	3	words	word	NOUN
bibechana-21109	100	4	,	,	PUNCT
bibechana-21109	100	5	the	the	DET
bibechana-21109	100	6	nature	nature	NOUN
bibechana-21109	100	7	of	of	ADP
bibechana-21109	100	8	rmsd	rmsd	NOUN
bibechana-21109	100	9	of	of	ADP
bibechana-21109	100	10	431	431	NUM
bibechana-21109	100	11	-	-	PUNCT
bibechana-21109	100	12	residue	residue	NOUN
bibechana-21109	100	13	change	change	NOUN
bibechana-21109	100	14	from	from	ADP
bibechana-21109	100	15	unliganded	unligande	VERB
bibechana-21109	100	16	to	to	ADP
bibechana-21109	100	17	liganded	ligande	VERB
bibechana-21109	100	18	as	as	ADV
bibechana-21109	100	19	well	well	ADV
bibechana-21109	100	20	as	as	ADP
bibechana-21109	100	21	wild	wild	ADJ
bibechana-21109	100	22	type	type	NOUN
bibechana-21109	100	23	to	to	PART
bibechana-21109	100	24	mutated	mutate	VERB
bibechana-21109	100	25	thr	thr	PROPN
bibechana-21109	100	26	-	-	PUNCT
bibechana-21109	100	27	β	β	NOUN
bibechana-21109	100	28	.	.	PUNCT
bibechana-21109	101	1	the	the	DET
bibechana-21109	101	2	rmsd	rmsd	NOUN
bibechana-21109	101	3	or	or	CCONJ
bibechana-21109	101	4	rg	rg	X
bibechana-21109	101	5	of	of	ADP
bibechana-21109	101	6	the	the	DET
bibechana-21109	101	7	protein	protein	NOUN
bibechana-21109	101	8	is	be	AUX
bibechana-21109	101	9	almost	almost	ADV
bibechana-21109	101	10	same	same	ADJ
bibechana-21109	101	11	with	with	ADP
bibechana-21109	101	12	small	small	ADJ
bibechana-21109	101	13	fluctuations	fluctuation	NOUN
bibechana-21109	101	14	for	for	ADP
bibechana-21109	101	15	these	these	DET
bibechana-21109	101	16	three	three	NUM
bibechana-21109	101	17	cases	case	NOUN
bibechana-21109	101	18	.	.	PUNCT
bibechana-21109	102	1	the	the	DET
bibechana-21109	102	2	protein	protein	NOUN
bibechana-21109	102	3	rmsd	rmsd	NOUN
bibechana-21109	102	4	is	be	AUX
bibechana-21109	102	5	about	about	ADV
bibechana-21109	102	6	2	2	NUM
bibechana-21109	102	7	å	å	NOUN
bibechana-21109	102	8	and	and	CCONJ
bibechana-21109	102	9	the	the	DET
bibechana-21109	102	10	protein	protein	NOUN
bibechana-21109	102	11	rg	rg	NOUN
bibechana-21109	102	12	is	be	AUX
bibechana-21109	102	13	about	about	ADV
bibechana-21109	102	14	19	19	NUM
bibechana-21109	102	15	å	å	NOUN
bibechana-21109	102	16	for	for	ADP
bibechana-21109	102	17	the	the	DET
bibechana-21109	102	18	wild	wild	ADJ
bibechana-21109	102	19	type	type	NOUN
bibechana-21109	102	20	and	and	CCONJ
bibechana-21109	102	21	the	the	DET
bibechana-21109	102	22	mutated	mutate	VERB
bibechana-21109	102	23	thr	thr	PROPN
bibechana-21109	102	24	-	-	PUNCT
bibechana-21109	102	25	β	β	NOUN
bibechana-21109	102	26	systems	system	NOUN
bibechana-21109	102	27	.	.	PUNCT
bibechana-21109	103	1	the	the	DET
bibechana-21109	103	2	rmsd	rmsd	NOUN
bibechana-21109	103	3	0510152025	0510152025	NUM
bibechana-21109	103	4	0	0	NUM
bibechana-21109	103	5	1000	1000	NUM
bibechana-21109	103	6	2000	2000	NUM
bibechana-21109	103	7	3000	3000	NUM
bibechana-21109	103	8	4000rg(å	4000rg(å	NUM
bibechana-21109	103	9	)	)	PUNCT
bibechana-21109	103	10	time	time	NOUN
bibechana-21109	103	11	frame	frame	NOUN
bibechana-21109	103	12	(	(	PUNCT
bibechana-21109	103	13	0.5ps	0.5ps	PROPN
bibechana-21109	103	14	/	/	SYM
bibechana-21109	103	15	frame)thr	frame)thr	NOUN
bibechana-21109	103	16	-	-	PUNCT
bibechana-21109	103	17	protein	protein	NOUN
bibechana-21109	103	18	i431v	i431v	PROPN
bibechana-21109	103	19	t30510152025	t30510152025	NOUN
bibechana-21109	103	20	0	0	NUM
bibechana-21109	103	21	1000	1000	NUM
bibechana-21109	103	22	2000	2000	NUM
bibechana-21109	103	23	3000	3000	NUM
bibechana-21109	103	24	4000rg(å	4000rg(å	NUM
bibechana-21109	103	25	)	)	PUNCT
bibechana-21109	103	26	time	time	NOUN
bibechana-21109	103	27	frame	frame	NOUN
bibechana-21109	103	28	(	(	PUNCT
bibechana-21109	103	29	0.5ps	0.5ps	PROPN
bibechana-21109	103	30	/	/	SYM
bibechana-21109	103	31	frame)thr	frame)thr	NOUN
bibechana-21109	103	32	-	-	PUNCT
bibechana-21109	103	33	protein	protein	NOUN
bibechana-21109	103	34	i4310510152025	i4310510152025	CCONJ
bibechana-21109	103	35	0	0	NUM
bibechana-21109	103	36	1000	1000	NUM
bibechana-21109	103	37	2000	2000	NUM
bibechana-21109	103	38	3000	3000	NUM
bibechana-21109	103	39	4000rg(å	4000rg(å	NUM
bibechana-21109	103	40	)	)	PUNCT
bibechana-21109	103	41	time	time	NOUN
bibechana-21109	103	42	frame	frame	NOUN
bibechana-21109	103	43	(	(	PUNCT
bibechana-21109	103	44	0.5ps	0.5ps	PROPN
bibechana-21109	103	45	/	/	SYM
bibechana-21109	103	46	frame)thr	frame)thr	NOUN
bibechana-21109	103	47	-	-	PUNCT
bibechana-21109	103	48	protein	protein	NOUN
bibechana-21109	103	49	i431	i431	PROPN
bibechana-21109	103	50	t3tika	t3tika	NOUN
bibechana-21109	103	51	ram	ram	NOUN
bibechana-21109	103	52	lamichhane	lamichhane	NOUN
bibechana-21109	103	53	et	et	PROPN
bibechana-21109	103	54	al./	al./	ADV
bibechana-21109	103	55	bibechana	bibechana	PROPN
bibechana-21109	103	56	16	16	NUM
bibechana-21109	103	57	(	(	PUNCT
bibechana-21109	103	58	2019	2019	NUM
bibechana-21109	103	59	)	)	PUNCT
bibechana-21109	103	60	79	79	NUM
bibechana-21109	103	61	-	-	SYM
bibechana-21109	103	62	91	91	NUM
bibechana-21109	103	63	:	:	PUNCT
bibechana-21109	103	64	rcost	rcost	NOUN
bibechana-21109	103	65	p.84	p.84	PROPN
bibechana-21109	103	66	(	(	PUNCT
bibechana-21109	103	67	online	online	ADJ
bibechana-21109	103	68	publication	publication	NOUN
bibechana-21109	103	69	:	:	PUNCT
bibechana-21109	103	70	dec	dec	PROPN
bibechana-21109	103	71	.	.	PROPN
bibechana-21109	103	72	,	,	PUNCT
bibechana-21109	103	73	2018	2018	NUM
bibechana-21109	103	74	)	)	PUNCT
bibechana-21109	103	75	and	and	CCONJ
bibechana-21109	103	76	rg	rg	PROPN
bibechana-21109	103	77	of	of	ADP
bibechana-21109	103	78	t3	t3	PROPN
bibechana-21109	103	79	-	-	PUNCT
bibechana-21109	103	80	hormone	hormone	NOUN
bibechana-21109	103	81	while	while	SCONJ
bibechana-21109	103	82	bounded	bound	VERB
bibechana-21109	103	83	in	in	ADP
bibechana-21109	103	84	the	the	DET
bibechana-21109	103	85	lbd	lbd	PROPN
bibechana-21109	103	86	of	of	ADP
bibechana-21109	103	87	nuclear	nuclear	ADJ
bibechana-21109	103	88	receptors	receptor	NOUN
bibechana-21109	103	89	are	be	AUX
bibechana-21109	103	90	0.7	0.7	NUM
bibechana-21109	103	91	å	å	NOUN
bibechana-21109	103	92	and	and	CCONJ
bibechana-21109	103	93	4.3	4.3	NUM
bibechana-21109	103	94	å	å	PROPN
bibechana-21109	103	95	respectively	respectively	ADV
bibechana-21109	103	96	.	.	PUNCT
bibechana-21109	104	1	(	(	PUNCT
bibechana-21109	104	2	a	a	X
bibechana-21109	104	3	)	)	PUNCT
bibechana-21109	104	4	(	(	PUNCT
bibechana-21109	104	5	b	b	X
bibechana-21109	104	6	)	)	PUNCT
bibechana-21109	104	7	(	(	PUNCT
bibechana-21109	104	8	c	c	X
bibechana-21109	104	9	)	)	PUNCT
bibechana-21109	104	10	fig	fig	NOUN
bibechana-21109	104	11	.	.	PUNCT
bibechana-21109	105	1	5	5	NUM
bibechana-21109	105	2	:	:	PUNCT
bibechana-21109	105	3	rg	rg	NOUN
bibechana-21109	105	4	-	-	PUNCT
bibechana-21109	105	5	plots	plot	NOUN
bibechana-21109	105	6	of	of	ADP
bibechana-21109	105	7	431	431	NUM
bibechana-21109	105	8	residue	residue	NOUN
bibechana-21109	105	9	,	,	PUNCT
bibechana-21109	105	10	thr	thr	NOUN
bibechana-21109	105	11	-	-	PUNCT
bibechana-21109	105	12	protein	protein	NOUN
bibechana-21109	105	13	and	and	CCONJ
bibechana-21109	105	14	t3	t3	NOUN
bibechana-21109	105	15	-	-	PUNCT
bibechana-21109	105	16	hormone	hormone	NOUN
bibechana-21109	105	17	during	during	ADP
bibechana-21109	105	18	equilibration	equilibration	NOUN
bibechana-21109	105	19	of	of	ADP
bibechana-21109	105	20	(	(	PUNCT
bibechana-21109	105	21	a	a	X
bibechana-21109	105	22	)	)	PUNCT
bibechana-21109	105	23	wild	wild	ADJ
bibechana-21109	105	24	type	type	NOUN
bibechana-21109	105	25	thr	thr	PROPN
bibechana-21109	105	26	,	,	PUNCT
bibechana-21109	105	27	(	(	PUNCT
bibechana-21109	105	28	b	b	X
bibechana-21109	105	29	)	)	PUNCT
bibechana-21109	105	30	wild	wild	ADJ
bibechana-21109	105	31	type	type	NOUN
bibechana-21109	105	32	thrt3	thrt3	PROPN
bibechana-21109	106	1	and	and	CCONJ
bibechana-21109	106	2	(	(	PUNCT
bibechana-21109	106	3	c	c	X
bibechana-21109	106	4	)	)	PUNCT
bibechana-21109	106	5	i431v	i431v	PROPN
bibechana-21109	106	6	-	-	PUNCT
bibechana-21109	106	7	mutant	mutant	NOUN
bibechana-21109	106	8	thrt3	thrt3	PROPN
bibechana-21109	106	9	.	.	PUNCT
bibechana-21109	107	1	table	table	NOUN
bibechana-21109	107	2	1	1	NUM
bibechana-21109	107	3	:	:	PUNCT
bibechana-21109	107	4	average	average	ADJ
bibechana-21109	107	5	values	value	NOUN
bibechana-21109	107	6	of	of	ADP
bibechana-21109	107	7	root	root	NOUN
bibechana-21109	107	8	mean	mean	ADJ
bibechana-21109	107	9	square	square	ADJ
bibechana-21109	107	10	deviation	deviation	NOUN
bibechana-21109	107	11	(	(	PUNCT
bibechana-21109	107	12	rmsd	rmsd	NOUN
bibechana-21109	107	13	)	)	PUNCT
bibechana-21109	107	14	and	and	CCONJ
bibechana-21109	107	15	radius	radius	NOUN
bibechana-21109	107	16	of	of	ADP
bibechana-21109	107	17	gyration	gyration	NOUN
bibechana-21109	107	18	(	(	PUNCT
bibechana-21109	107	19	rg	rg	NOUN
bibechana-21109	107	20	)	)	PUNCT
bibechana-21109	107	21	of	of	ADP
bibechana-21109	107	22	unliganded	unligande	VERB
bibechana-21109	107	23	wild	wild	ADJ
bibechana-21109	107	24	type	type	NOUN
bibechana-21109	107	25	and	and	CCONJ
bibechana-21109	107	26	t3	t3	NOUN
bibechana-21109	107	27	-	-	PUNCT
bibechana-21109	107	28	liganded	ligande	VERB
bibechana-21109	107	29	wild	wild	ADJ
bibechana-21109	107	30	type	type	NOUN
bibechana-21109	107	31	and	and	CCONJ
bibechana-21109	107	32	i431v	i431v	PROPN
bibechana-21109	107	33	-	-	PUNCT
bibechana-21109	107	34	mutant	mutant	NOUN
bibechana-21109	107	35	thr	thr	PROPN
bibechana-21109	107	36	-	-	PUNCT
bibechana-21109	107	37	β	β	NOUN
bibechana-21109	107	38	including	include	VERB
bibechana-21109	107	39	with	with	ADP
bibechana-21109	107	40	the	the	DET
bibechana-21109	107	41	standard	standard	ADJ
bibechana-21109	107	42	deviation	deviation	NOUN
bibechana-21109	107	43	of	of	ADP
bibechana-21109	107	44	the	the	DET
bibechana-21109	107	45	data	datum	NOUN
bibechana-21109	107	46	obtained	obtain	VERB
bibechana-21109	107	47	after	after	ADP
bibechana-21109	107	48	mds	mds	NOUN
bibechana-21109	107	49	by	by	ADP
bibechana-21109	107	50	their	their	PRON
bibechana-21109	107	51	equilibration	equilibration	NOUN
bibechana-21109	107	52	runs	run	NOUN
bibechana-21109	107	53	.	.	PUNCT
bibechana-21109	108	1	molecule	molecule	NOUN
bibechana-21109	108	2	thr	thr	PROPN
bibechana-21109	108	3	-	-	PUNCT
bibechana-21109	108	4	wt	wt	NOUN
bibechana-21109	108	5	thrt3	thrt3	NOUN
bibechana-21109	108	6	-	-	PUNCT
bibechana-21109	108	7	wt	wt	NOUN
bibechana-21109	108	8	thrt3	thrt3	PROPN
bibechana-21109	108	9	-	-	PUNCT
bibechana-21109	108	10	mt	mt	PROPN
bibechana-21109	108	11	i431	i431	PROPN
bibechana-21109	108	12	protein	protein	NOUN
bibechana-21109	108	13	i431	i431	PROPN
bibechana-21109	108	14	t3	t3	NOUN
bibechana-21109	108	15	protein	protein	NOUN
bibechana-21109	108	16	i431v	i431v	PROPN
bibechana-21109	108	17	t3	t3	NOUN
bibechana-21109	108	18	protein	protein	NOUN
bibechana-21109	108	19	rmsd(å	rmsd(å	PROPN
bibechana-21109	108	20	)	)	PUNCT
bibechana-21109	108	21	4.6	4.6	NUM
bibechana-21109	108	22	±	±	NUM
bibechana-21109	108	23	2.4	2.4	NUM
bibechana-21109	108	24	2.0	2.0	NUM
bibechana-21109	108	25	±	±	NUM
bibechana-21109	108	26	0.2	0.2	NUM
bibechana-21109	108	27	3.6	3.6	NUM
bibechana-21109	108	28	±	±	NUM
bibechana-21109	108	29	1.6	1.6	NUM
bibechana-21109	108	30	0.7	0.7	NUM
bibechana-21109	108	31	±	±	NUM
bibechana-21109	108	32	0.1	0.1	NUM
bibechana-21109	108	33	2.0	2.0	NUM
bibechana-21109	108	34	±	±	NUM
bibechana-21109	108	35	0.3	0.3	NUM
bibechana-21109	108	36	3.5	3.5	NUM
bibechana-21109	108	37	±	±	NUM
bibechana-21109	108	38	1.5	1.5	NUM
bibechana-21109	108	39	0.7	0.7	NUM
bibechana-21109	108	40	±	±	NUM
bibechana-21109	108	41	0.1	0.1	NUM
bibechana-21109	108	42	2.3	2.3	NUM
bibechana-21109	108	43	±	±	NUM
bibechana-21109	108	44	0.4	0.4	NUM
bibechana-21109	108	45	rg(å	rg(å	SYM
bibechana-21109	108	46	)	)	PUNCT
bibechana-21109	108	47	10.3	10.3	NUM
bibechana-21109	108	48	±	±	NUM
bibechana-21109	108	49	3.7	3.7	NUM
bibechana-21109	108	50	18.8	18.8	NUM
bibechana-21109	108	51	±	±	NUM
bibechana-21109	108	52	0.1	0.1	NUM
bibechana-21109	108	53	12.1	12.1	NUM
bibechana-21109	108	54	±	±	NUM
bibechana-21109	108	55	3.1	3.1	NUM
bibechana-21109	108	56	4.3	4.3	NUM
bibechana-21109	108	57	±	±	NUM
bibechana-21109	108	58	0.1	0.1	NUM
bibechana-21109	108	59	19.2	19.2	NUM
bibechana-21109	108	60	±	±	NUM
bibechana-21109	108	61	0.2	0.2	NUM
bibechana-21109	108	62	12.8	12.8	NUM
bibechana-21109	108	63	±	±	NUM
bibechana-21109	108	64	3.6	3.6	NUM
bibechana-21109	108	65	4.3	4.3	NUM
bibechana-21109	108	66	±	±	NUM
bibechana-21109	108	67	0.1	0.1	NUM
bibechana-21109	108	68	19.1	19.1	NUM
bibechana-21109	108	69	±	±	NUM
bibechana-21109	108	70	0.1	0.1	NUM
bibechana-21109	108	71	in	in	ADP
bibechana-21109	108	72	this	this	DET
bibechana-21109	108	73	study	study	NOUN
bibechana-21109	108	74	,	,	PUNCT
bibechana-21109	108	75	the	the	DET
bibechana-21109	108	76	root	root	NOUN
bibechana-21109	108	77	mean	mean	VERB
bibechana-21109	108	78	square	square	ADJ
bibechana-21109	108	79	fluctuations	fluctuation	NOUN
bibechana-21109	108	80	(	(	PUNCT
bibechana-21109	108	81	rmsf	rmsf	NOUN
bibechana-21109	108	82	)	)	PUNCT
bibechana-21109	108	83	of	of	ADP
bibechana-21109	108	84	most	most	ADJ
bibechana-21109	108	85	of	of	ADP
bibechana-21109	108	86	the	the	DET
bibechana-21109	108	87	residues	residue	NOUN
bibechana-21109	108	88	of	of	ADP
bibechana-21109	108	89	thrt3	thrt3	NOUN
bibechana-21109	108	90	-	-	PUNCT
bibechana-21109	108	91	wt	wt	NOUN
bibechana-21109	108	92	are	be	AUX
bibechana-21109	108	93	observed	observe	VERB
bibechana-21109	108	94	to	to	PART
bibechana-21109	108	95	be	be	AUX
bibechana-21109	108	96	a	a	DET
bibechana-21109	108	97	little	little	ADJ
bibechana-21109	108	98	bit	bit	NOUN
bibechana-21109	108	99	larger	large	ADJ
bibechana-21109	108	100	than	than	ADP
bibechana-21109	108	101	that	that	PRON
bibechana-21109	108	102	of	of	ADP
bibechana-21109	108	103	thr	thr	PROPN
bibechana-21109	108	104	-	-	PUNCT
bibechana-21109	108	105	wt	wt	NOUN
bibechana-21109	108	106	and	and	CCONJ
bibechana-21109	108	107	thrt3	thrt3	PROPN
bibechana-21109	108	108	-	-	PUNCT
bibechana-21109	108	109	mt	mt	PROPN
bibechana-21109	108	110	as	as	SCONJ
bibechana-21109	108	111	shown	show	VERB
bibechana-21109	108	112	in	in	ADP
bibechana-21109	108	113	fig	fig	NOUN
bibechana-21109	108	114	.	.	PUNCT
bibechana-21109	109	1	6	6	NUM
bibechana-21109	109	2	.	.	X
bibechana-21109	109	3	in	in	ADP
bibechana-21109	109	4	the	the	DET
bibechana-21109	109	5	i431v	i431v	PROPN
bibechana-21109	109	6	mutational	mutational	ADJ
bibechana-21109	109	7	site	site	NOUN
bibechana-21109	109	8	,	,	PUNCT
bibechana-21109	109	9	the	the	DET
bibechana-21109	109	10	values	value	NOUN
bibechana-21109	109	11	of	of	ADP
bibechana-21109	109	12	rmsf	rmsf	NOUN
bibechana-21109	109	13	are	be	AUX
bibechana-21109	109	14	3.2	3.2	NUM
bibechana-21109	109	15	å	å	NOUN
bibechana-21109	109	16	for	for	ADP
bibechana-21109	109	17	ile	ile	PROPN
bibechana-21109	109	18	of	of	ADP
bibechana-21109	109	19	thr	thr	PROPN
bibechana-21109	109	20	-	-	PUNCT
bibechana-21109	109	21	wt	wt	NOUN
bibechana-21109	109	22	,	,	PUNCT
bibechana-21109	109	23	4.1	4.1	NUM
bibechana-21109	109	24	å	å	NOUN
bibechana-21109	109	25	for	for	ADP
bibechana-21109	109	26	ile	ile	PROPN
bibechana-21109	109	27	of	of	ADP
bibechana-21109	109	28	thrt3	thrt3	PROPN
bibechana-21109	109	29	-	-	PUNCT
bibechana-21109	109	30	wt	wt	PROPN
bibechana-21109	109	31	and	and	CCONJ
bibechana-21109	109	32	3.0	3.0	NUM
bibechana-21109	109	33	å	å	NOUN
bibechana-21109	109	34	for	for	ADP
bibechana-21109	109	35	val	val	NOUN
bibechana-21109	109	36	of	of	ADP
bibechana-21109	109	37	thrt3	thrt3	PROPN
bibechana-21109	109	38	-	-	PUNCT
bibechana-21109	109	39	mt	mt	PROPN
bibechana-21109	109	40	.	.	PUNCT
bibechana-21109	110	1	the	the	DET
bibechana-21109	110	2	residues	residue	NOUN
bibechana-21109	110	3	in	in	ADP
bibechana-21109	110	4	helix-1	helix-1	PROPN
bibechana-21109	110	5	have	have	VERB
bibechana-21109	110	6	the	the	DET
bibechana-21109	110	7	highest	high	ADJ
bibechana-21109	110	8	rmsf	rmsf	NOUN
bibechana-21109	110	9	so	so	SCONJ
bibechana-21109	110	10	that	that	SCONJ
bibechana-21109	110	11	the	the	DET
bibechana-21109	110	12	helix-1	helix-1	NOUN
bibechana-21109	110	13	in	in	ADP
bibechana-21109	110	14	thrt3	thrt3	NOUN
bibechana-21109	110	15	-	-	PUNCT
bibechana-21109	110	16	wt	wt	PROPN
bibechana-21109	110	17	is	be	AUX
bibechana-21109	110	18	more	more	ADV
bibechana-21109	110	19	flexible	flexible	ADJ
bibechana-21109	110	20	.	.	PUNCT
bibechana-21109	111	1	fig	fig	NOUN
bibechana-21109	111	2	.	.	PUNCT
bibechana-21109	112	1	6	6	NUM
bibechana-21109	112	2	:	:	PUNCT
bibechana-21109	112	3	rmsf	rmsf	NOUN
bibechana-21109	112	4	of	of	ADP
bibechana-21109	112	5	amino	amino	NOUN
bibechana-21109	112	6	acid	acid	NOUN
bibechana-21109	112	7	residues	residue	NOUN
bibechana-21109	112	8	of	of	ADP
bibechana-21109	112	9	thr	thr	PROPN
bibechana-21109	112	10	-	-	PUNCT
bibechana-21109	112	11	wt	wt	NOUN
bibechana-21109	112	12	,	,	PUNCT
bibechana-21109	112	13	thrt3	thrt3	NOUN
bibechana-21109	112	14	-	-	PUNCT
bibechana-21109	112	15	wt	wt	NOUN
bibechana-21109	112	16	and	and	CCONJ
bibechana-21109	112	17	i431v	i431v	PROPN
bibechana-21109	112	18	-	-	PUNCT
bibechana-21109	112	19	mutant	mutant	NOUN
bibechana-21109	112	20	thrt3	thrt3	PROPN
bibechana-21109	112	21	-	-	PUNCT
bibechana-21109	112	22	mt	mt	PROPN
bibechana-21109	112	23	during	during	ADP
bibechana-21109	112	24	their	their	PRON
bibechana-21109	112	25	2	2	NUM
bibechana-21109	112	26	ns	ns	NUM
bibechana-21109	112	27	equilibration	equilibration	NOUN
bibechana-21109	112	28	run	run	NOUN
bibechana-21109	112	29	.	.	PUNCT
bibechana-21109	113	1	024681012	024681012	NUM
bibechana-21109	113	2	200	200	NUM
bibechana-21109	113	3	220	220	NUM
bibechana-21109	113	4	240	240	NUM
bibechana-21109	113	5	260	260	NUM
bibechana-21109	113	6	280	280	NUM
bibechana-21109	113	7	300	300	NUM
bibechana-21109	113	8	320	320	NUM
bibechana-21109	113	9	340	340	NUM
bibechana-21109	113	10	360	360	NUM
bibechana-21109	113	11	380	380	NUM
bibechana-21109	113	12	400	400	NUM
bibechana-21109	113	13	420	420	NUM
bibechana-21109	113	14	440	440	NUM
bibechana-21109	113	15	460rmsf	460rmsf	PROPN
bibechana-21109	113	16	(	(	PUNCT
bibechana-21109	113	17	å	å	NOUN
bibechana-21109	113	18	)	)	PUNCT
bibechana-21109	113	19	amino	amino	NOUN
bibechana-21109	113	20	acid	acid	NOUN
bibechana-21109	113	21	residuesthr	residuesthr	PROPN
bibechana-21109	113	22	-	-	PUNCT
bibechana-21109	113	23	wt	wt	NOUN
bibechana-21109	113	24	thrt3	thrt3	NOUN
bibechana-21109	113	25	-	-	PUNCT
bibechana-21109	113	26	wt	wt	NOUN
bibechana-21109	113	27	thrt3	thrt3	PROPN
bibechana-21109	113	28	-	-	PUNCT
bibechana-21109	113	29	mt	mt	PROPN
bibechana-21109	113	30	i431v	i431v	PROPN
bibechana-21109	113	31	mutational	mutational	ADJ
bibechana-21109	113	32	site	site	NOUN
bibechana-21109	113	33	tika	tika	X
bibechana-21109	113	34	ram	ram	NOUN
bibechana-21109	113	35	lamichhane	lamichhane	NOUN
bibechana-21109	113	36	et	et	PROPN
bibechana-21109	113	37	al./	al./	ADV
bibechana-21109	113	38	bibechana	bibechana	PROPN
bibechana-21109	113	39	16	16	NUM
bibechana-21109	113	40	(	(	PUNCT
bibechana-21109	113	41	2019	2019	NUM
bibechana-21109	113	42	)	)	PUNCT
bibechana-21109	113	43	79	79	NUM
bibechana-21109	113	44	-	-	SYM
bibechana-21109	113	45	91	91	NUM
bibechana-21109	113	46	:	:	PUNCT
bibechana-21109	113	47	rcost	rcost	NOUN
bibechana-21109	113	48	p.85	p.85	ADP
bibechana-21109	113	49	(	(	PUNCT
bibechana-21109	113	50	online	online	ADJ
bibechana-21109	113	51	publication	publication	NOUN
bibechana-21109	113	52	:	:	PUNCT
bibechana-21109	114	1	dec	dec	PROPN
bibechana-21109	114	2	.	.	PROPN
bibechana-21109	114	3	,	,	PUNCT
bibechana-21109	114	4	2018	2018	NUM
bibechana-21109	114	5	)	)	PUNCT
bibechana-21109	114	6	solvent	solvent	ADJ
bibechana-21109	114	7	accessible	accessible	ADJ
bibechana-21109	114	8	surface	surface	NOUN
bibechana-21109	114	9	area	area	NOUN
bibechana-21109	114	10	(	(	PUNCT
bibechana-21109	114	11	sasa	sasa	PROPN
bibechana-21109	114	12	)	)	PUNCT
bibechana-21109	114	13	of	of	ADP
bibechana-21109	114	14	thr	thr	PROPN
bibechana-21109	114	15	-	-	PUNCT
bibechana-21109	114	16	wt	wt	NOUN
bibechana-21109	114	17	,	,	PUNCT
bibechana-21109	114	18	thrt3	thrt3	NOUN
bibechana-21109	114	19	-	-	PUNCT
bibechana-21109	114	20	wt	wt	NOUN
bibechana-21109	114	21	and	and	CCONJ
bibechana-21109	114	22	thrt3	thrt3	PROPN
bibechana-21109	114	23	-	-	PUNCT
bibechana-21109	114	24	mt	mt	PROPN
bibechana-21109	114	25	are	be	AUX
bibechana-21109	114	26	observed	observe	VERB
bibechana-21109	114	27	to	to	PART
bibechana-21109	114	28	be	be	AUX
bibechana-21109	114	29	slightly	slightly	ADV
bibechana-21109	114	30	different	different	ADJ
bibechana-21109	114	31	in	in	ADP
bibechana-21109	114	32	the	the	DET
bibechana-21109	114	33	extension	extension	NOUN
bibechana-21109	114	34	radius	radius	NOUN
bibechana-21109	114	35	of	of	ADP
bibechana-21109	114	36	1.4	1.4	NUM
bibechana-21109	114	37	å	å	NOUN
bibechana-21109	114	38	.	.	PUNCT
bibechana-21109	115	1	after	after	ADP
bibechana-21109	115	2	500	500	NUM
bibechana-21109	115	3	frames	frame	NOUN
bibechana-21109	115	4	of	of	ADP
bibechana-21109	115	5	energy	energy	NOUN
bibechana-21109	115	6	minimization	minimization	NOUN
bibechana-21109	115	7	and	and	CCONJ
bibechana-21109	115	8	equilibration	equilibration	NOUN
bibechana-21109	115	9	,	,	PUNCT
bibechana-21109	115	10	the	the	DET
bibechana-21109	115	11	sasa	sasa	NOUN
bibechana-21109	115	12	with	with	ADP
bibechana-21109	115	13	the	the	DET
bibechana-21109	115	14	standard	standard	ADJ
bibechana-21109	115	15	deviation	deviation	NOUN
bibechana-21109	115	16	of	of	ADP
bibechana-21109	115	17	the	the	DET
bibechana-21109	115	18	data	datum	NOUN
bibechana-21109	115	19	from	from	ADP
bibechana-21109	115	20	frame	frame	NOUN
bibechana-21109	115	21	to	to	PART
bibechana-21109	115	22	frame	frame	VERB
bibechana-21109	115	23	simulation	simulation	NOUN
bibechana-21109	115	24	up	up	ADP
bibechana-21109	115	25	to	to	PART
bibechana-21109	115	26	2	2	NUM
bibechana-21109	115	27	ns	ns	NUM
bibechana-21109	115	28	is	be	AUX
bibechana-21109	115	29	13620.1	13620.1	NUM
bibechana-21109	115	30	±	±	NUM
bibechana-21109	115	31	253.07	253.07	NUM
bibechana-21109	115	32	å2	å2	NOUN
bibechana-21109	115	33	for	for	ADP
bibechana-21109	115	34	thr	thr	PROPN
bibechana-21109	115	35	-	-	PUNCT
bibechana-21109	115	36	wt	wt	NOUN
bibechana-21109	115	37	,	,	PUNCT
bibechana-21109	115	38	13952.4	13952.4	NUM
bibechana-21109	115	39	±	±	NUM
bibechana-21109	115	40	130.9	130.9	NUM
bibechana-21109	115	41	å2	å2	NOUN
bibechana-21109	115	42	for	for	ADP
bibechana-21109	115	43	thrt3	thrt3	NOUN
bibechana-21109	115	44	-	-	PUNCT
bibechana-21109	115	45	wt	wt	NOUN
bibechana-21109	115	46	and	and	CCONJ
bibechana-21109	115	47	13721.0	13721.0	NUM
bibechana-21109	115	48	±	±	NUM
bibechana-21109	115	49	147.9	147.9	NUM
bibechana-21109	115	50	å2	å2	NOUN
bibechana-21109	115	51	for	for	ADP
bibechana-21109	115	52	thrt3	thrt3	PROPN
bibechana-21109	115	53	-	-	PUNCT
bibechana-21109	115	54	mt	mt	PROPN
bibechana-21109	115	55	.	.	PROPN
bibechana-21109	116	1	in	in	ADP
bibechana-21109	116	2	this	this	DET
bibechana-21109	116	3	way	way	NOUN
bibechana-21109	116	4	,	,	PUNCT
bibechana-21109	116	5	the	the	DET
bibechana-21109	116	6	sasa	sasa	NOUN
bibechana-21109	116	7	of	of	ADP
bibechana-21109	116	8	431	431	NUM
bibechana-21109	116	9	-	-	PUNCT
bibechana-21109	116	10	residue	residue	NOUN
bibechana-21109	116	11	is	be	AUX
bibechana-21109	116	12	14.8	14.8	NUM
bibechana-21109	116	13	±	±	NUM
bibechana-21109	116	14	9.0	9.0	NUM
bibechana-21109	116	15	å2	å2	NOUN
bibechana-21109	116	16	for	for	ADP
bibechana-21109	116	17	thr	thr	PROPN
bibechana-21109	116	18	-	-	PUNCT
bibechana-21109	116	19	wt	wt	NOUN
bibechana-21109	116	20	,	,	PUNCT
bibechana-21109	116	21	12.6	12.6	NUM
bibechana-21109	116	22	±	±	NUM
bibechana-21109	116	23	10.1	10.1	NUM
bibechana-21109	116	24	å2	å2	NOUN
bibechana-21109	116	25	for	for	ADP
bibechana-21109	116	26	thrt3	thrt3	NOUN
bibechana-21109	116	27	-	-	PUNCT
bibechana-21109	116	28	wt	wt	NOUN
bibechana-21109	116	29	and	and	CCONJ
bibechana-21109	116	30	17.4	17.4	NUM
bibechana-21109	116	31	±	±	NUM
bibechana-21109	116	32	8.1	8.1	NUM
bibechana-21109	116	33	å2	å2	PROPN
bibechana-21109	116	34	for	for	ADP
bibechana-21109	116	35	thrt3	thrt3	PROPN
bibechana-21109	116	36	-	-	PUNCT
bibechana-21109	116	37	mt	mt	PROPN
bibechana-21109	116	38	.	.	PUNCT
bibechana-21109	117	1	the	the	DET
bibechana-21109	117	2	lower	low	ADJ
bibechana-21109	117	3	sasa	sasa	PROPN
bibechana-21109	117	4	indicates	indicate	VERB
bibechana-21109	117	5	the	the	DET
bibechana-21109	117	6	higher	high	ADJ
bibechana-21109	117	7	thermodynamic	thermodynamic	ADJ
bibechana-21109	117	8	stability	stability	NOUN
bibechana-21109	117	9	of	of	ADP
bibechana-21109	117	10	the	the	DET
bibechana-21109	117	11	protein	protein	NOUN
bibechana-21109	117	12	.	.	PUNCT
bibechana-21109	118	1	the	the	DET
bibechana-21109	118	2	sasa	sasa	NOUN
bibechana-21109	118	3	of	of	ADP
bibechana-21109	118	4	t3	t3	PROPN
bibechana-21109	118	5	-	-	PUNCT
bibechana-21109	118	6	hormone	hormone	NOUN
bibechana-21109	118	7	is	be	AUX
bibechana-21109	118	8	observed	observe	VERB
bibechana-21109	118	9	to	to	PART
bibechana-21109	118	10	be	be	AUX
bibechana-21109	118	11	zero	zero	NUM
bibechana-21109	118	12	indicating	indicate	VERB
bibechana-21109	118	13	the	the	DET
bibechana-21109	118	14	hydrophobicity	hydrophobicity	NOUN
bibechana-21109	118	15	of	of	ADP
bibechana-21109	118	16	lbd	lbd	PROPN
bibechana-21109	118	17	of	of	ADP
bibechana-21109	118	18	thr	thr	PROPN
bibechana-21109	118	19	-	-	PUNCT
bibechana-21109	118	20	β	β	NOUN
bibechana-21109	118	21	.	.	PUNCT
bibechana-21109	119	1	the	the	DET
bibechana-21109	119	2	mutation	mutation	NOUN
bibechana-21109	119	3	on	on	ADP
bibechana-21109	119	4	the	the	DET
bibechana-21109	119	5	solvent	solvent	ADJ
bibechana-21109	119	6	accessible	accessible	ADJ
bibechana-21109	119	7	residue	residue	NOUN
bibechana-21109	119	8	causes	cause	VERB
bibechana-21109	119	9	the	the	DET
bibechana-21109	119	10	conformational	conformational	ADJ
bibechana-21109	119	11	change	change	NOUN
bibechana-21109	119	12	by	by	ADP
bibechana-21109	119	13	partial	partial	ADJ
bibechana-21109	119	14	unfolding	unfolding	NOUN
bibechana-21109	119	15	of	of	ADP
bibechana-21109	119	16	the	the	DET
bibechana-21109	119	17	protein	protein	NOUN
bibechana-21109	119	18	with	with	ADP
bibechana-21109	119	19	increasing	increase	VERB
bibechana-21109	119	20	sasa	sasa	NOUN
bibechana-21109	120	1	[	[	X
bibechana-21109	120	2	28	28	NUM
bibechana-21109	120	3	]	]	PUNCT
bibechana-21109	120	4	.	.	PUNCT
bibechana-21109	121	1	such	such	ADJ
bibechana-21109	121	2	effect	effect	NOUN
bibechana-21109	121	3	is	be	AUX
bibechana-21109	121	4	more	more	ADV
bibechana-21109	121	5	intensive	intensive	ADJ
bibechana-21109	121	6	if	if	SCONJ
bibechana-21109	121	7	the	the	DET
bibechana-21109	121	8	mutation	mutation	NOUN
bibechana-21109	121	9	occurs	occur	VERB
bibechana-21109	121	10	on	on	ADP
bibechana-21109	121	11	the	the	DET
bibechana-21109	121	12	surface	surface	NOUN
bibechana-21109	121	13	residue	residue	NOUN
bibechana-21109	121	14	than	than	ADP
bibechana-21109	121	15	on	on	ADP
bibechana-21109	121	16	the	the	DET
bibechana-21109	121	17	interior	interior	NOUN
bibechana-21109	121	18	of	of	ADP
bibechana-21109	121	19	the	the	DET
bibechana-21109	121	20	protein	protein	NOUN
bibechana-21109	121	21	.	.	PUNCT
bibechana-21109	122	1	the	the	DET
bibechana-21109	122	2	i431v	i431v	PROPN
bibechana-21109	122	3	mutation	mutation	NOUN
bibechana-21109	122	4	is	be	AUX
bibechana-21109	122	5	the	the	DET
bibechana-21109	122	6	interior	interior	ADJ
bibechana-21109	122	7	one	one	NUM
bibechana-21109	122	8	so	so	SCONJ
bibechana-21109	122	9	that	that	SCONJ
bibechana-21109	122	10	no	no	DET
bibechana-21109	122	11	significant	significant	ADJ
bibechana-21109	122	12	change	change	NOUN
bibechana-21109	122	13	in	in	ADP
bibechana-21109	122	14	sasa	sasa	NOUN
bibechana-21109	122	15	of	of	ADP
bibechana-21109	122	16	wild	wild	ADJ
bibechana-21109	122	17	type	type	NOUN
bibechana-21109	122	18	and	and	CCONJ
bibechana-21109	122	19	mutated	mutate	VERB
bibechana-21109	122	20	thr	thr	PROPN
bibechana-21109	122	21	-	-	PUNCT
bibechana-21109	122	22	β	β	PROPN
bibechana-21109	122	23	has	have	AUX
bibechana-21109	122	24	been	be	AUX
bibechana-21109	122	25	observed	observe	VERB
bibechana-21109	122	26	after	after	ADP
bibechana-21109	122	27	their	their	PRON
bibechana-21109	122	28	2	2	NUM
bibechana-21109	122	29	ns	ns	NUM
bibechana-21109	122	30	equilibration	equilibration	NOUN
bibechana-21109	122	31	.	.	PUNCT
bibechana-21109	123	1	however	however	ADV
bibechana-21109	123	2	,	,	PUNCT
bibechana-21109	123	3	the	the	DET
bibechana-21109	123	4	total	total	ADJ
bibechana-21109	123	5	sasa	sasa	NOUN
bibechana-21109	123	6	of	of	ADP
bibechana-21109	123	7	thr	thr	PROPN
bibechana-21109	123	8	-	-	PUNCT
bibechana-21109	123	9	wt	wt	NOUN
bibechana-21109	123	10	and	and	CCONJ
bibechana-21109	123	11	thrt3	thrt3	PROPN
bibechana-21109	123	12	-	-	PUNCT
bibechana-21109	123	13	mt	mt	PROPN
bibechana-21109	123	14	are	be	AUX
bibechana-21109	123	15	more	more	ADV
bibechana-21109	123	16	fluctuating	fluctuating	ADJ
bibechana-21109	123	17	than	than	ADP
bibechana-21109	123	18	that	that	PRON
bibechana-21109	123	19	of	of	ADP
bibechana-21109	123	20	thrt3	thrt3	PROPN
bibechana-21109	123	21	-	-	PUNCT
bibechana-21109	123	22	wt	wt	NOUN
bibechana-21109	123	23	up	up	ADP
bibechana-21109	123	24	to	to	PART
bibechana-21109	123	25	3000	3000	NUM
bibechana-21109	123	26	frames	frame	NOUN
bibechana-21109	123	27	of	of	ADP
bibechana-21109	123	28	the	the	DET
bibechana-21109	123	29	equilibration	equilibration	NOUN
bibechana-21109	123	30	runs	run	NOUN
bibechana-21109	123	31	(	(	PUNCT
bibechana-21109	123	32	fig	fig	NOUN
bibechana-21109	123	33	.	.	PUNCT
bibechana-21109	124	1	7	7	NUM
bibechana-21109	124	2	-	-	SYM
bibechana-21109	124	3	a	a	PRON
bibechana-21109	124	4	)	)	PUNCT
bibechana-21109	124	5	.	.	PUNCT
bibechana-21109	125	1	furthermore	furthermore	ADV
bibechana-21109	125	2	,	,	PUNCT
bibechana-21109	125	3	sasa	sasa	NOUN
bibechana-21109	125	4	of	of	ADP
bibechana-21109	125	5	i431v	i431v	PROPN
bibechana-21109	125	6	-	-	PUNCT
bibechana-21109	125	7	mutant	mutant	NOUN
bibechana-21109	125	8	is	be	AUX
bibechana-21109	125	9	higher	high	ADJ
bibechana-21109	125	10	and	and	CCONJ
bibechana-21109	125	11	less	less	ADV
bibechana-21109	125	12	fluctuating	fluctuating	NOUN
bibechana-21109	125	13	than	than	ADP
bibechana-21109	125	14	that	that	PRON
bibechana-21109	125	15	of	of	ADP
bibechana-21109	125	16	native	native	ADJ
bibechana-21109	125	17	and	and	CCONJ
bibechana-21109	125	18	wild	wild	ADJ
bibechana-21109	125	19	type	type	NOUN
bibechana-21109	125	20	i431	i431	PROPN
bibechana-21109	125	21	-	-	PUNCT
bibechana-21109	125	22	rsidue	rsidue	NOUN
bibechana-21109	125	23	of	of	ADP
bibechana-21109	125	24	thr	thr	PROPN
bibechana-21109	125	25	-	-	PUNCT
bibechana-21109	125	26	β	β	NOUN
bibechana-21109	125	27	(	(	PUNCT
bibechana-21109	125	28	fig.7	fig.7	PROPN
bibechana-21109	125	29	-	-	PUNCT
bibechana-21109	125	30	b	b	NOUN
bibechana-21109	125	31	)	)	PUNCT
bibechana-21109	125	32	.	.	PUNCT
bibechana-21109	126	1	(	(	PUNCT
bibechana-21109	126	2	a	a	X
bibechana-21109	126	3	)	)	PUNCT
bibechana-21109	126	4	(	(	PUNCT
bibechana-21109	126	5	b	b	X
bibechana-21109	126	6	)	)	PUNCT
bibechana-21109	126	7	fig	fig	NOUN
bibechana-21109	126	8	.	.	PUNCT
bibechana-21109	127	1	7	7	NUM
bibechana-21109	127	2	:	:	PUNCT
bibechana-21109	127	3	(	(	PUNCT
bibechana-21109	127	4	a	a	X
bibechana-21109	127	5	)	)	PUNCT
bibechana-21109	127	6	sasa	sasa	NOUN
bibechana-21109	127	7	of	of	ADP
bibechana-21109	127	8	protein	protein	NOUN
bibechana-21109	127	9	in	in	ADP
bibechana-21109	127	10	wild	wild	ADJ
bibechana-21109	127	11	type	type	NOUN
bibechana-21109	127	12	thr	thr	PROPN
bibechana-21109	127	13	,	,	PUNCT
bibechana-21109	127	14	thrt3	thrt3	NOUN
bibechana-21109	127	15	and	and	CCONJ
bibechana-21109	127	16	mutated	mutate	VERB
bibechana-21109	127	17	-	-	PUNCT
bibechana-21109	127	18	thrt3	thrt3	NOUN
bibechana-21109	127	19	,	,	PUNCT
bibechana-21109	127	20	(	(	PUNCT
bibechana-21109	127	21	b	b	X
bibechana-21109	127	22	)	)	PUNCT
bibechana-21109	127	23	sasa	sasa	NOUN
bibechana-21109	127	24	of	of	ADP
bibechana-21109	127	25	i431	i431	PROPN
bibechana-21109	127	26	residue	residue	NOUN
bibechana-21109	127	27	in	in	ADP
bibechana-21109	127	28	thrt3	thrt3	NOUN
bibechana-21109	127	29	-	-	PUNCT
bibechana-21109	127	30	wt	wt	NOUN
bibechana-21109	127	31	and	and	CCONJ
bibechana-21109	127	32	i431v	i431v	PROPN
bibechana-21109	127	33	mutant	mutant	NOUN
bibechana-21109	127	34	in	in	ADP
bibechana-21109	127	35	thrt3	thrt3	PROPN
bibechana-21109	127	36	-	-	PUNCT
bibechana-21109	127	37	mt	mt	PROPN
bibechana-21109	127	38	during	during	ADP
bibechana-21109	127	39	their	their	PRON
bibechana-21109	127	40	equilibration	equilibration	NOUN
bibechana-21109	127	41	runs	run	NOUN
bibechana-21109	127	42	.	.	PUNCT
bibechana-21109	128	1	the	the	DET
bibechana-21109	128	2	distributions	distribution	NOUN
bibechana-21109	128	3	of	of	ADP
bibechana-21109	128	4	number	number	NOUN
bibechana-21109	128	5	of	of	ADP
bibechana-21109	128	6	h	h	NOUN
bibechana-21109	128	7	-	-	PUNCT
bibechana-21109	128	8	bonds	bond	NOUN
bibechana-21109	128	9	along	along	ADP
bibechana-21109	128	10	with	with	ADP
bibechana-21109	128	11	the	the	DET
bibechana-21109	128	12	frame	frame	NOUN
bibechana-21109	128	13	order	order	NOUN
bibechana-21109	128	14	of	of	ADP
bibechana-21109	128	15	the	the	DET
bibechana-21109	128	16	simulations	simulation	NOUN
bibechana-21109	128	17	up	up	ADP
bibechana-21109	128	18	to	to	PART
bibechana-21109	128	19	2	2	NUM
bibechana-21109	128	20	ns	ns	NUM
bibechana-21109	128	21	equilibrations	equilibration	NOUN
bibechana-21109	128	22	are	be	AUX
bibechana-21109	128	23	shown	show	VERB
bibechana-21109	128	24	in	in	ADP
bibechana-21109	128	25	fig	fig	NOUN
bibechana-21109	128	26	.	.	PUNCT
bibechana-21109	129	1	8	8	X
bibechana-21109	129	2	.	.	PUNCT
bibechana-21109	130	1	here	here	ADV
bibechana-21109	130	2	,	,	PUNCT
bibechana-21109	130	3	the	the	DET
bibechana-21109	130	4	average	average	ADJ
bibechana-21109	130	5	values	value	NOUN
bibechana-21109	130	6	of	of	ADP
bibechana-21109	130	7	h	h	NOUN
bibechana-21109	130	8	-	-	PUNCT
bibechana-21109	130	9	bond	bond	NOUN
bibechana-21109	130	10	number	number	NOUN
bibechana-21109	130	11	with	with	ADP
bibechana-21109	130	12	the	the	DET
bibechana-21109	130	13	standard	standard	ADJ
bibechana-21109	130	14	deviation	deviation	NOUN
bibechana-21109	130	15	of	of	ADP
bibechana-21109	130	16	the	the	DET
bibechana-21109	130	17	data	datum	NOUN
bibechana-21109	130	18	after	after	ADP
bibechana-21109	130	19	500	500	NUM
bibechana-21109	130	20	frames	frame	NOUN
bibechana-21109	130	21	with	with	ADP
bibechana-21109	130	22	the	the	DET
bibechana-21109	130	23	donor	donor	NOUN
bibechana-21109	130	24	-	-	PUNCT
bibechana-21109	130	25	acceptor	acceptor	NOUN
bibechana-21109	130	26	distance	distance	NOUN
bibechana-21109	130	27	4.0	4.0	NUM
bibechana-21109	130	28	å	å	NOUN
bibechana-21109	130	29	and	and	CCONJ
bibechana-21109	130	30	cut	cut	VERB
bibechana-21109	130	31	-	-	PUNCT
bibechana-21109	130	32	off	off	ADP
bibechana-21109	130	33	angle	angle	NOUN
bibechana-21109	130	34	40o	40o	NOUN
bibechana-21109	130	35	among	among	ADP
bibechana-21109	130	36	n	n	PRON
bibechana-21109	130	37	and	and	CCONJ
bibechana-21109	130	38	o	o	NOUN
bibechana-21109	130	39	atoms	atom	NOUN
bibechana-21109	130	40	are	be	AUX
bibechana-21109	130	41	5	5	NUM
bibechana-21109	130	42	±	±	NUM
bibechana-21109	130	43	2	2	NUM
bibechana-21109	130	44	for	for	ADP
bibechana-21109	130	45	i431	i431	PROPN
bibechana-21109	130	46	-	-	PUNCT
bibechana-21109	130	47	thr(wt	thr(wt	NOUN
bibechana-21109	130	48	)	)	PUNCT
bibechana-21109	130	49	,	,	PUNCT
bibechana-21109	130	50	16	16	NUM
bibechana-21109	130	51	±	±	NUM
bibechana-21109	130	52	4	4	NUM
bibechana-21109	130	53	for	for	ADP
bibechana-21109	130	54	t3	t3	NOUN
bibechana-21109	130	55	-	-	PUNCT
bibechana-21109	130	56	thr(wt	thr(wt	NOUN
bibechana-21109	130	57	)	)	PUNCT
bibechana-21109	130	58	,	,	PUNCT
bibechana-21109	130	59	4	4	NUM
bibechana-21109	130	60	±	±	NUM
bibechana-21109	130	61	2	2	NUM
bibechana-21109	130	62	for	for	ADP
bibechana-21109	130	63	i431	i431	PROPN
bibechana-21109	130	64	-	-	PUNCT
bibechana-21109	130	65	thr(mt	thr(mt	NOUN
bibechana-21109	130	66	)	)	PUNCT
bibechana-21109	130	67	and	and	CCONJ
bibechana-21109	130	68	15	15	NUM
bibechana-21109	130	69	±	±	NUM
bibechana-21109	130	70	4	4	NUM
bibechana-21109	130	71	for	for	ADP
bibechana-21109	130	72	t3	t3	NOUN
bibechana-21109	130	73	-	-	PUNCT
bibechana-21109	130	74	thr(mt	thr(mt	NOUN
bibechana-21109	130	75	)	)	PUNCT
bibechana-21109	130	76	.	.	PUNCT
bibechana-21109	131	1	during	during	ADP
bibechana-21109	131	2	mds	mds	PROPN
bibechana-21109	131	3	of	of	ADP
bibechana-21109	131	4	the	the	DET
bibechana-21109	131	5	wild	wild	ADJ
bibechana-21109	131	6	type	type	NOUN
bibechana-21109	131	7	and	and	CCONJ
bibechana-21109	131	8	mutated	mutate	VERB
bibechana-21109	131	9	thr	thr	PROPN
bibechana-21109	131	10	-	-	PUNCT
bibechana-21109	131	11	β	β	NOUN
bibechana-21109	131	12	systems	system	NOUN
bibechana-21109	131	13	,	,	PUNCT
bibechana-21109	131	14	the	the	DET
bibechana-21109	131	15	distance	distance	NOUN
bibechana-21109	131	16	between	between	ADP
bibechana-21109	131	17	i431	i431	PROPN
bibechana-21109	131	18	and	and	CCONJ
bibechana-21109	131	19	t3	t3	PROPN
bibechana-21109	131	20	in	in	ADP
bibechana-21109	131	21	thrt3	thrt3	PROPN
bibechana-21109	131	22	-	-	PUNCT
bibechana-21109	131	23	wt	wt	NOUN
bibechana-21109	131	24	varies	vary	VERB
bibechana-21109	131	25	as	as	ADP
bibechana-21109	131	26	10.2	10.2	NUM
bibechana-21109	131	27	±	±	NUM
bibechana-21109	131	28	2.6	2.6	NUM
bibechana-21109	131	29	å	å	NOUN
bibechana-21109	131	30	and	and	CCONJ
bibechana-21109	131	31	the	the	DET
bibechana-21109	131	32	distance	distance	NOUN
bibechana-21109	131	33	between	between	ADP
bibechana-21109	131	34	i431v	i431v	PROPN
bibechana-21109	131	35	and	and	CCONJ
bibechana-21109	131	36	t3	t3	PROPN
bibechana-21109	131	37	in	in	ADP
bibechana-21109	131	38	thrt3	thrt3	PROPN
bibechana-21109	131	39	-	-	PUNCT
bibechana-21109	131	40	mt	mt	PROPN
bibechana-21109	131	41	varies	vary	VERB
bibechana-21109	131	42	as	as	ADP
bibechana-21109	131	43	13.1	13.1	NUM
bibechana-21109	131	44	±	±	NUM
bibechana-21109	131	45	2.0	2.0	NUM
bibechana-21109	131	46	å	å	NOUN
bibechana-21109	131	47	as	as	SCONJ
bibechana-21109	131	48	shown	show	VERB
bibechana-21109	131	49	in	in	ADP
bibechana-21109	131	50	fig	fig	NOUN
bibechana-21109	131	51	.	.	PUNCT
bibechana-21109	132	1	9	9	NUM
bibechana-21109	132	2	-	-	PUNCT
bibechana-21109	132	3	b.	b.	NOUN
bibechana-21109	132	4	such	such	ADJ
bibechana-21109	132	5	distance	distance	NOUN
bibechana-21109	132	6	is	be	AUX
bibechana-21109	132	7	smaller	small	ADJ
bibechana-21109	132	8	and	and	CCONJ
bibechana-21109	132	9	more	more	ADJ
bibechana-21109	132	10	fluctuating	fluctuating	NOUN
bibechana-21109	132	11	in	in	ADP
bibechana-21109	132	12	thrt3	thrt3	NOUN
bibechana-21109	132	13	-	-	PUNCT
bibechana-21109	132	14	wt	wt	NOUN
bibechana-21109	132	15	than	than	ADP
bibechana-21109	132	16	in	in	ADP
bibechana-21109	132	17	thrt3	thrt3	PROPN
bibechana-21109	132	18	-	-	PUNCT
bibechana-21109	132	19	mt	mt	PROPN
bibechana-21109	132	20	.	.	PUNCT
bibechana-21109	133	1	this	this	PRON
bibechana-21109	133	2	is	be	AUX
bibechana-21109	133	3	one	one	NUM
bibechana-21109	133	4	of	of	ADP
bibechana-21109	133	5	the	the	DET
bibechana-21109	133	6	indicators	indicator	NOUN
bibechana-21109	133	7	of	of	ADP
bibechana-21109	133	8	t3	t3	PROPN
bibechana-21109	133	9	resistant	resistant	ADJ
bibechana-21109	133	10	features	feature	NOUN
bibechana-21109	133	11	of	of	ADP
bibechana-21109	133	12	mutated	mutate	VERB
bibechana-21109	133	13	nuclear	nuclear	ADJ
bibechana-21109	133	14	receptor	receptor	NOUN
bibechana-21109	133	15	proteins	protein	NOUN
bibechana-21109	133	16	that	that	PRON
bibechana-21109	133	17	cause	cause	VERB
bibechana-21109	133	18	rth	rth	PROPN
bibechana-21109	133	19	.	.	PROPN
bibechana-21109	133	20	radial	radial	ADJ
bibechana-21109	133	21	distribution	distribution	NOUN
bibechana-21109	133	22	function	function	NOUN
bibechana-21109	133	23	[	[	X
bibechana-21109	133	24	29	29	NUM
bibechana-21109	133	25	]	]	PUNCT
bibechana-21109	133	26	or	or	CCONJ
bibechana-21109	133	27	pair	pair	VERB
bibechana-21109	133	28	auto	auto	NOUN
bibechana-21109	133	29	-	-	PUNCT
bibechana-21109	133	30	correlation	correlation	NOUN
bibechana-21109	133	31	function	function	NOUN
bibechana-21109	133	32	g(r	g(r	PROPN
bibechana-21109	133	33	)	)	PUNCT
bibechana-21109	133	34	in	in	ADP
bibechana-21109	133	35	a	a	DET
bibechana-21109	133	36	system	system	NOUN
bibechana-21109	133	37	of	of	ADP
bibechana-21109	133	38	particles	particle	NOUN
bibechana-21109	133	39	measures	measure	VERB
bibechana-21109	133	40	probability	probability	NOUN
bibechana-21109	133	41	of	of	ADP
bibechana-21109	133	42	finding	find	VERB
bibechana-21109	133	43	a	a	DET
bibechana-21109	133	44	particle	particle	NOUN
bibechana-21109	133	45	at	at	ADP
bibechana-21109	133	46	r	r	NOUN
bibechana-21109	133	47	distance	distance	NOUN
bibechana-21109	133	48	away	away	ADV
bibechana-21109	133	49	from	from	ADP
bibechana-21109	133	50	the	the	DET
bibechana-21109	133	51	reference	reference	NOUN
bibechana-21109	133	52	particle	particle	NOUN
bibechana-21109	133	53	.	.	PUNCT
bibechana-21109	134	1	the	the	DET
bibechana-21109	134	2	distribution	distribution	NOUN
bibechana-21109	134	3	function	function	NOUN
bibechana-21109	134	4	g(r	g(r	NOUN
bibechana-21109	134	5	)	)	PUNCT
bibechana-21109	134	6	between	between	ADP
bibechana-21109	134	7	i431	i431	PROPN
bibechana-21109	134	8	-	-	PUNCT
bibechana-21109	134	9	residue	residue	NOUN
bibechana-21109	134	10	and	and	CCONJ
bibechana-21109	134	11	t3	t3	NOUN
bibechana-21109	134	12	-	-	PUNCT
bibechana-21109	134	13	hormone	hormone	NOUN
bibechana-21109	134	14	has	have	VERB
bibechana-21109	134	15	the	the	DET
bibechana-21109	134	16	higher	high	ADJ
bibechana-21109	134	17	value	value	NOUN
bibechana-21109	134	18	than	than	ADP
bibechana-21109	134	19	that	that	PRON
bibechana-21109	134	20	between	between	ADP
bibechana-21109	134	21	i431v	i431v	PROPN
bibechana-21109	134	22	and	and	CCONJ
bibechana-21109	134	23	t3	t3	PROPN
bibechana-21109	134	24	12000125001300013500140001450015000	12000125001300013500140001450015000	NUM
bibechana-21109	134	25	0	0	NUM
bibechana-21109	134	26	1000	1000	NUM
bibechana-21109	134	27	2000	2000	NUM
bibechana-21109	134	28	3000	3000	NUM
bibechana-21109	134	29	4000sasa	4000sasa	NOUN
bibechana-21109	134	30	(	(	PUNCT
bibechana-21109	134	31	å2	å2	NOUN
bibechana-21109	134	32	)	)	PUNCT
bibechana-21109	134	33	frame	frame	NOUN
bibechana-21109	134	34	order	order	NOUN
bibechana-21109	134	35	(	(	PUNCT
bibechana-21109	134	36	0.5ps	0.5ps	PROPN
bibechana-21109	134	37	/	/	SYM
bibechana-21109	134	38	frame)thr	frame)thr	PROPN
bibechana-21109	134	39	-	-	PUNCT
bibechana-21109	134	40	wt	wt	NOUN
bibechana-21109	134	41	thrt3	thrt3	NOUN
bibechana-21109	134	42	-	-	PUNCT
bibechana-21109	134	43	wt	wt	NOUN
bibechana-21109	134	44	thrt3	thrt3	PROPN
bibechana-21109	134	45	-	-	PUNCT
bibechana-21109	134	46	mt	mt	PROPN
bibechana-21109	134	47	020406080	020406080	NUM
bibechana-21109	134	48	0	0	NUM
bibechana-21109	135	1	1000	1000	NUM
bibechana-21109	135	2	2000	2000	NUM
bibechana-21109	135	3	3000	3000	NUM
bibechana-21109	135	4	4000sasa(å2	4000sasa(å2	NUM
bibechana-21109	135	5	)	)	PUNCT
bibechana-21109	135	6	frame	frame	NOUN
bibechana-21109	135	7	order	order	NOUN
bibechana-21109	135	8	(	(	PUNCT
bibechana-21109	135	9	0.5ps	0.5ps	NUM
bibechana-21109	135	10	/	/	SYM
bibechana-21109	135	11	frame)i431	frame)i431	NOUN
bibechana-21109	135	12	i431v	i431v	PROPN
bibechana-21109	135	13	05101520	05101520	NUM
bibechana-21109	135	14	0	0	NUM
bibechana-21109	135	15	5	5	NUM
bibechana-21109	135	16	10	10	NUM
bibechana-21109	135	17	15	15	NUM
bibechana-21109	135	18	20	20	NUM
bibechana-21109	135	19	25	25	NUM
bibechana-21109	135	20	g	g	NOUN
bibechana-21109	135	21	(	(	PUNCT
bibechana-21109	135	22	r	r	NOUN
bibechana-21109	135	23	)	)	PUNCT
bibechana-21109	135	24	r	r	NOUN
bibechana-21109	135	25	(	(	PUNCT
bibechana-21109	135	26	å	å	NOUN
bibechana-21109	135	27	)	)	PUNCT
bibechana-21109	135	28	i431v	i431v	PROPN
bibechana-21109	135	29	-	-	PUNCT
bibechana-21109	135	30	t3i431	t3i431	PROPN
bibechana-21109	135	31	-	-	ADJ
bibechana-21109	135	32	t305101520	t305101520	NOUN
bibechana-21109	135	33	0	0	NUM
bibechana-21109	135	34	1000	1000	NUM
bibechana-21109	135	35	2000	2000	NUM
bibechana-21109	135	36	3000	3000	NUM
bibechana-21109	135	37	4000distance(å	4000distance(å	NUM
bibechana-21109	135	38	)	)	PUNCT
bibechana-21109	135	39	frame	frame	NOUN
bibechana-21109	135	40	order	order	NOUN
bibechana-21109	135	41	(	(	PUNCT
bibechana-21109	135	42	0.5ps	0.5ps	NOUN
bibechana-21109	135	43	/	/	SYM
bibechana-21109	135	44	frame)i431	frame)i431	NOUN
bibechana-21109	135	45	-	-	PUNCT
bibechana-21109	135	46	t3	t3	NOUN
bibechana-21109	135	47	i431v	i431v	PROPN
bibechana-21109	135	48	-	-	PUNCT
bibechana-21109	135	49	t3tika	t3tika	PROPN
bibechana-21109	135	50	ram	ram	NOUN
bibechana-21109	135	51	lamichhane	lamichhane	NOUN
bibechana-21109	135	52	et	et	PROPN
bibechana-21109	135	53	al./	al./	ADV
bibechana-21109	135	54	bibechana	bibechana	PROPN
bibechana-21109	135	55	16	16	NUM
bibechana-21109	135	56	(	(	PUNCT
bibechana-21109	135	57	2019	2019	NUM
bibechana-21109	135	58	)	)	PUNCT
bibechana-21109	135	59	79	79	NUM
bibechana-21109	135	60	-	-	SYM
bibechana-21109	135	61	91	91	NUM
bibechana-21109	135	62	:	:	PUNCT
bibechana-21109	135	63	rcost	rcost	NOUN
bibechana-21109	135	64	p.86	p.86	PROPN
bibechana-21109	135	65	(	(	PUNCT
bibechana-21109	135	66	online	online	ADJ
bibechana-21109	135	67	publication	publication	NOUN
bibechana-21109	135	68	:	:	PUNCT
bibechana-21109	135	69	dec	dec	PROPN
bibechana-21109	135	70	.	.	PROPN
bibechana-21109	135	71	,	,	PUNCT
bibechana-21109	135	72	2018	2018	NUM
bibechana-21109	135	73	)	)	PUNCT
bibechana-21109	135	74	and	and	CCONJ
bibechana-21109	135	75	it	it	PRON
bibechana-21109	135	76	lies	lie	VERB
bibechana-21109	135	77	in	in	ADP
bibechana-21109	135	78	the	the	DET
bibechana-21109	135	79	range	range	NOUN
bibechana-21109	135	80	of	of	ADP
bibechana-21109	135	81	5	5	NUM
bibechana-21109	135	82	å	å	NOUN
bibechana-21109	135	83	and	and	CCONJ
bibechana-21109	135	84	18	18	NUM
bibechana-21109	135	85	å	å	PROPN
bibechana-21109	135	86	as	as	SCONJ
bibechana-21109	135	87	shown	show	VERB
bibechana-21109	135	88	in	in	ADP
bibechana-21109	135	89	fig	fig	NOUN
bibechana-21109	135	90	.	.	PUNCT
bibechana-21109	136	1	9	9	NUM
bibechana-21109	136	2	-	-	PUNCT
bibechana-21109	136	3	c.	c.	NOUN
bibechana-21109	136	4	in	in	ADP
bibechana-21109	136	5	other	other	ADJ
bibechana-21109	136	6	words	word	NOUN
bibechana-21109	136	7	,	,	PUNCT
bibechana-21109	136	8	the	the	DET
bibechana-21109	136	9	number	number	NOUN
bibechana-21109	136	10	density	density	NOUN
bibechana-21109	136	11	of	of	ADP
bibechana-21109	136	12	mutated	mutate	VERB
bibechana-21109	136	13	residue	residue	NOUN
bibechana-21109	136	14	is	be	AUX
bibechana-21109	136	15	less	less	ADJ
bibechana-21109	136	16	than	than	ADP
bibechana-21109	136	17	that	that	PRON
bibechana-21109	136	18	of	of	ADP
bibechana-21109	136	19	the	the	DET
bibechana-21109	136	20	native	native	ADJ
bibechana-21109	136	21	wild	wild	ADJ
bibechana-21109	136	22	type	type	NOUN
bibechana-21109	136	23	residue	residue	NOUN
bibechana-21109	136	24	to	to	PART
bibechana-21109	136	25	respond	respond	VERB
bibechana-21109	136	26	for	for	ADP
bibechana-21109	136	27	t3	t3	NOUN
bibechana-21109	136	28	-	-	PUNCT
bibechana-21109	136	29	hormone	hormone	NOUN
bibechana-21109	136	30	and	and	CCONJ
bibechana-21109	136	31	tres	tre	NOUN
bibechana-21109	136	32	.	.	PUNCT
bibechana-21109	137	1	(	(	PUNCT
bibechana-21109	137	2	a	a	X
bibechana-21109	137	3	)	)	PUNCT
bibechana-21109	137	4	(	(	PUNCT
bibechana-21109	137	5	b	b	X
bibechana-21109	137	6	)	)	PUNCT
bibechana-21109	137	7	fig	fig	NOUN
bibechana-21109	137	8	.	.	PUNCT
bibechana-21109	138	1	8	8	NUM
bibechana-21109	138	2	:	:	PUNCT
bibechana-21109	138	3	variation	variation	NOUN
bibechana-21109	138	4	of	of	ADP
bibechana-21109	138	5	number	number	NOUN
bibechana-21109	138	6	of	of	ADP
bibechana-21109	138	7	h	h	NOUN
bibechana-21109	138	8	-	-	PUNCT
bibechana-21109	138	9	bonds	bond	NOUN
bibechana-21109	138	10	between	between	ADP
bibechana-21109	138	11	431	431	NUM
bibechana-21109	138	12	-	-	PUNCT
bibechana-21109	138	13	residue	residue	NOUN
bibechana-21109	138	14	and	and	CCONJ
bibechana-21109	138	15	protein	protein	NOUN
bibechana-21109	138	16	vs.	vs.	ADP
bibechana-21109	138	17	simulation	simulation	NOUN
bibechana-21109	138	18	time	time	NOUN
bibechana-21109	138	19	in	in	ADP
bibechana-21109	138	20	case	case	NOUN
bibechana-21109	138	21	of	of	ADP
bibechana-21109	138	22	(	(	PUNCT
bibechana-21109	138	23	a	a	X
bibechana-21109	138	24	)	)	PUNCT
bibechana-21109	138	25	wild	wild	ADJ
bibechana-21109	138	26	type	type	NOUN
bibechana-21109	138	27	and	and	CCONJ
bibechana-21109	138	28	(	(	PUNCT
bibechana-21109	138	29	b	b	NOUN
bibechana-21109	138	30	)	)	PUNCT
bibechana-21109	138	31	i431v	i431v	PROPN
bibechana-21109	138	32	-	-	PUNCT
bibechana-21109	138	33	mutant	mutant	NOUN
bibechana-21109	138	34	thrt3	thrt3	PROPN
bibechana-21109	138	35	systems	system	NOUN
bibechana-21109	138	36	.	.	PUNCT
bibechana-21109	139	1	(	(	PUNCT
bibechana-21109	139	2	a	a	X
bibechana-21109	139	3	)	)	PUNCT
bibechana-21109	139	4	(	(	PUNCT
bibechana-21109	139	5	b	b	X
bibechana-21109	139	6	)	)	PUNCT
bibechana-21109	139	7	(	(	PUNCT
bibechana-21109	139	8	c	c	X
bibechana-21109	139	9	)	)	PUNCT
bibechana-21109	139	10	fig	fig	NOUN
bibechana-21109	139	11	.	.	PUNCT
bibechana-21109	140	1	9	9	NUM
bibechana-21109	140	2	:	:	PUNCT
bibechana-21109	140	3	(	(	PUNCT
bibechana-21109	140	4	a	a	X
bibechana-21109	140	5	)	)	PUNCT
bibechana-21109	140	6	positions	position	NOUN
bibechana-21109	140	7	of	of	ADP
bibechana-21109	140	8	i431v	i431v	PROPN
bibechana-21109	140	9	-	-	PUNCT
bibechana-21109	140	10	mutant	mutant	NOUN
bibechana-21109	140	11	and	and	CCONJ
bibechana-21109	140	12	t3	t3	NOUN
bibechana-21109	140	13	-	-	PUNCT
bibechana-21109	140	14	hormone	hormone	NOUN
bibechana-21109	140	15	in	in	ADP
bibechana-21109	140	16	thrt3	thrt3	PROPN
bibechana-21109	140	17	-	-	PUNCT
bibechana-21109	140	18	mt	mt	PROPN
bibechana-21109	140	19	,	,	PUNCT
bibechana-21109	140	20	(	(	PUNCT
bibechana-21109	140	21	b	b	NOUN
bibechana-21109	140	22	)	)	PUNCT
bibechana-21109	140	23	changing	change	VERB
bibechana-21109	140	24	distance	distance	NOUN
bibechana-21109	140	25	between	between	ADP
bibechana-21109	140	26	431	431	NUM
bibechana-21109	140	27	-	-	PUNCT
bibechana-21109	140	28	codon	codon	ADJ
bibechana-21109	140	29	and	and	CCONJ
bibechana-21109	140	30	t3	t3	NOUN
bibechana-21109	140	31	while	while	SCONJ
bibechana-21109	140	32	equilibrating	equilibrate	VERB
bibechana-21109	140	33	thrt3	thrt3	PROPN
bibechana-21109	140	34	-	-	PUNCT
bibechana-21109	140	35	wt	wt	NOUN
bibechana-21109	140	36	and	and	CCONJ
bibechana-21109	140	37	thrt3	thrt3	PROPN
bibechana-21109	140	38	-	-	PUNCT
bibechana-21109	140	39	mt	mt	PROPN
bibechana-21109	140	40	systems	system	NOUN
bibechana-21109	140	41	and	and	CCONJ
bibechana-21109	140	42	(	(	PUNCT
bibechana-21109	140	43	c	c	NOUN
bibechana-21109	140	44	)	)	PUNCT
bibechana-21109	140	45	radial	radial	ADJ
bibechana-21109	140	46	distribution	distribution	NOUN
bibechana-21109	140	47	functions	function	NOUN
bibechana-21109	140	48	between	between	ADP
bibechana-21109	140	49	431	431	NUM
bibechana-21109	140	50	-	-	PUNCT
bibechana-21109	140	51	residue	residue	NOUN
bibechana-21109	140	52	and	and	CCONJ
bibechana-21109	140	53	t3	t3	NOUN
bibechana-21109	140	54	-	-	PUNCT
bibechana-21109	140	55	hormone	hormone	NOUN
bibechana-21109	140	56	in	in	ADP
bibechana-21109	140	57	case	case	NOUN
bibechana-21109	140	58	of	of	ADP
bibechana-21109	140	59	wild	wild	ADJ
bibechana-21109	140	60	type	type	NOUN
bibechana-21109	140	61	and	and	CCONJ
bibechana-21109	140	62	mutated	mutate	VERB
bibechana-21109	140	63	thrt3	thrt3	PROPN
bibechana-21109	140	64	.	.	PUNCT
bibechana-21109	141	1	ir	ir	PROPN
bibechana-21109	141	2	spectral	spectral	ADJ
bibechana-21109	141	3	densities	density	NOUN
bibechana-21109	141	4	using	use	VERB
bibechana-21109	141	5	total	total	ADJ
bibechana-21109	141	6	dipole	dipole	NOUN
bibechana-21109	141	7	moment	moment	NOUN
bibechana-21109	141	8	of	of	ADP
bibechana-21109	141	9	the	the	DET
bibechana-21109	141	10	atoms	atom	NOUN
bibechana-21109	141	11	in	in	ADP
bibechana-21109	141	12	431	431	NUM
bibechana-21109	141	13	-	-	PUNCT
bibechana-21109	141	14	residue	residue	NOUN
bibechana-21109	141	15	and	and	CCONJ
bibechana-21109	141	16	t3	t3	NOUN
bibechana-21109	141	17	are	be	AUX
bibechana-21109	141	18	calculated	calculate	VERB
bibechana-21109	141	19	in	in	ADP
bibechana-21109	141	20	the	the	DET
bibechana-21109	141	21	frequency	frequency	NOUN
bibechana-21109	141	22	range	range	NOUN
bibechana-21109	141	23	of	of	ADP
bibechana-21109	141	24	0	0	NUM
bibechana-21109	141	25	to	to	ADP
bibechana-21109	141	26	2000	2000	NUM
bibechana-21109	141	27	cm-1	cm-1	NOUN
bibechana-21109	141	28	and	and	CCONJ
bibechana-21109	141	29	their	their	PRON
bibechana-21109	141	30	plots	plot	NOUN
bibechana-21109	141	31	are	be	AUX
bibechana-21109	141	32	different	different	ADJ
bibechana-21109	141	33	for	for	ADP
bibechana-21109	141	34	thrt3	thrt3	NOUN
bibechana-21109	141	35	-	-	PUNCT
bibechana-21109	141	36	wt	wt	NOUN
bibechana-21109	141	37	and	and	CCONJ
bibechana-21109	141	38	thrt3	thrt3	PROPN
bibechana-21109	141	39	-	-	PUNCT
bibechana-21109	141	40	mt	mt	PROPN
bibechana-21109	141	41	as	as	SCONJ
bibechana-21109	141	42	shown	show	VERB
bibechana-21109	141	43	in	in	ADP
bibechana-21109	141	44	fig	fig	NOUN
bibechana-21109	141	45	.	.	PUNCT
bibechana-21109	142	1	10	10	NUM
bibechana-21109	142	2	.	.	PUNCT
bibechana-21109	143	1	the	the	DET
bibechana-21109	143	2	maximum	maximum	PROPN
bibechana-21109	143	3	ir	ir	NOUN
bibechana-21109	143	4	-	-	NOUN
bibechana-21109	143	5	intensity	intensity	NOUN
bibechana-21109	143	6	of	of	ADP
bibechana-21109	143	7	t3	t3	PROPN
bibechana-21109	143	8	in	in	ADP
bibechana-21109	143	9	the	the	DET
bibechana-21109	143	10	wild	wild	ADJ
bibechana-21109	143	11	type	type	NOUN
bibechana-21109	143	12	receptor	receptor	NOUN
bibechana-21109	143	13	is	be	AUX
bibechana-21109	143	14	0.041	0.041	NUM
bibechana-21109	143	15	at	at	ADP
bibechana-21109	143	16	1837.42	1837.42	NUM
bibechana-21109	143	17	cm-1	cm-1	NOUN
bibechana-21109	143	18	and	and	CCONJ
bibechana-21109	143	19	that	that	PRON
bibechana-21109	143	20	of	of	ADP
bibechana-21109	143	21	i431	i431	PROPN
bibechana-21109	143	22	(	(	PUNCT
bibechana-21109	143	23	wild	wild	ADJ
bibechana-21109	143	24	type	type	NOUN
bibechana-21109	143	25	)	)	PUNCT
bibechana-21109	143	26	is	be	AUX
bibechana-21109	143	27	0.027	0.027	NUM
bibechana-21109	143	28	at	at	ADP
bibechana-21109	143	29	1637.88	1637.88	NUM
bibechana-21109	143	30	cm-1	cm-1	NOUN
bibechana-21109	143	31	.	.	PUNCT
bibechana-21109	144	1	again	again	ADV
bibechana-21109	144	2	,	,	PUNCT
bibechana-21109	144	3	the	the	DET
bibechana-21109	144	4	maximum	maximum	ADJ
bibechana-21109	144	5	ir	ir	NOUN
bibechana-21109	144	6	-	-	NOUN
bibechana-21109	144	7	intensity	intensity	NOUN
bibechana-21109	144	8	of	of	ADP
bibechana-21109	144	9	t3	t3	PROPN
bibechana-21109	144	10	in	in	ADP
bibechana-21109	144	11	the	the	DET
bibechana-21109	144	12	mutated	mutate	VERB
bibechana-21109	144	13	receptor	receptor	NOUN
bibechana-21109	144	14	is	be	AUX
bibechana-21109	144	15	0.037	0.037	NUM
bibechana-21109	144	16	at	at	ADP
bibechana-21109	144	17	1313.63	1313.63	NUM
bibechana-21109	144	18	cm-1	cm-1	NOUN
bibechana-21109	144	19	and	and	CCONJ
bibechana-21109	144	20	that	that	PRON
bibechana-21109	144	21	for	for	ADP
bibechana-21109	144	22	i431v	i431v	PROPN
bibechana-21109	144	23	-	-	PUNCT
bibechana-21109	144	24	mutant	mutant	NOUN
bibechana-21109	144	25	is	be	AUX
bibechana-21109	144	26	0.029	0.029	NUM
bibechana-21109	144	27	at	at	ADP
bibechana-21109	144	28	1571.37	1571.37	NUM
bibechana-21109	144	29	cm-1	cm-1	NOUN
bibechana-21109	144	30	.	.	PUNCT
bibechana-21109	145	1	the	the	DET
bibechana-21109	145	2	distribution	distribution	NOUN
bibechana-21109	145	3	has	have	VERB
bibechana-21109	145	4	larger	large	ADJ
bibechana-21109	145	5	number	number	NOUN
bibechana-21109	145	6	of	of	ADP
bibechana-21109	145	7	high	high	ADJ
bibechana-21109	145	8	intensity	intensity	NOUN
bibechana-21109	145	9	peaks	peak	NOUN
bibechana-21109	145	10	for	for	ADP
bibechana-21109	145	11	t3	t3	PROPN
bibechana-21109	145	12	and	and	CCONJ
bibechana-21109	145	13	i431v	i431v	PROPN
bibechana-21109	145	14	in	in	ADP
bibechana-21109	145	15	thrt3	thrt3	PROPN
bibechana-21109	145	16	-	-	PUNCT
bibechana-21109	145	17	mt	mt	PROPN
bibechana-21109	145	18	than	than	ADP
bibechana-21109	145	19	in	in	ADP
bibechana-21109	145	20	thrt3	thrt3	PROPN
bibechana-21109	145	21	-	-	PUNCT
bibechana-21109	145	22	wt	wt	PROPN
bibechana-21109	145	23	.	.	PROPN
bibechana-21109	145	24	total	total	ADJ
bibechana-21109	145	25	non	non	ADJ
bibechana-21109	145	26	-	-	ADJ
bibechana-21109	145	27	bonding	bonding	ADJ
bibechana-21109	145	28	interaction	interaction	NOUN
bibechana-21109	145	29	energy	energy	NOUN
bibechana-21109	145	30	is	be	AUX
bibechana-21109	145	31	the	the	DET
bibechana-21109	145	32	sum	sum	NOUN
bibechana-21109	145	33	of	of	ADP
bibechana-21109	145	34	electrostatic	electrostatic	ADJ
bibechana-21109	145	35	and	and	CCONJ
bibechana-21109	145	36	van	van	PROPN
bibechana-21109	145	37	der	der	PROPN
bibechana-21109	145	38	waal	waal	PROPN
bibechana-21109	145	39	’s	’s	PART
bibechana-21109	145	40	interaction	interaction	NOUN
bibechana-21109	145	41	energy	energy	NOUN
bibechana-21109	145	42	.	.	PUNCT
bibechana-21109	146	1	the	the	DET
bibechana-21109	146	2	changing	change	VERB
bibechana-21109	146	3	values	value	NOUN
bibechana-21109	146	4	of	of	ADP
bibechana-21109	146	5	interaction	interaction	NOUN
bibechana-21109	146	6	energy	energy	NOUN
bibechana-21109	146	7	between	between	ADP
bibechana-21109	146	8	431	431	NUM
bibechana-21109	146	9	-	-	PUNCT
bibechana-21109	146	10	residue	residue	NOUN
bibechana-21109	146	11	and	and	CCONJ
bibechana-21109	146	12	t3	t3	NOUN
bibechana-21109	146	13	-	-	PUNCT
bibechana-21109	146	14	hormone	hormone	NOUN
bibechana-21109	146	15	in	in	ADP
bibechana-21109	146	16	wild	wild	ADJ
bibechana-21109	146	17	type	type	NOUN
bibechana-21109	146	18	and	and	CCONJ
bibechana-21109	146	19	mutated	mutate	VERB
bibechana-21109	146	20	thr	thr	PROPN
bibechana-21109	146	21	-	-	PUNCT
bibechana-21109	146	22	β	β	NOUN
bibechana-21109	146	23	systems	system	NOUN
bibechana-21109	146	24	are	be	AUX
bibechana-21109	146	25	plotted	plot	VERB
bibechana-21109	146	26	with	with	ADP
bibechana-21109	146	27	respect	respect	NOUN
bibechana-21109	146	28	to	to	ADP
bibechana-21109	146	29	the	the	DET
bibechana-21109	146	30	frame	frame	NOUN
bibechana-21109	146	31	order	order	NOUN
bibechana-21109	146	32	in	in	ADP
bibechana-21109	146	33	fig	fig	NOUN
bibechana-21109	146	34	.	.	PUNCT
bibechana-21109	147	1	11	11	NUM
bibechana-21109	148	1	and	and	CCONJ
bibechana-21109	148	2	these	these	PRON
bibechana-21109	148	3	are	be	AUX
bibechana-21109	148	4	averaged	average	VERB
bibechana-21109	148	5	05101520253035	05101520253035	NUM
bibechana-21109	148	6	0	0	NUM
bibechana-21109	148	7	1000	1000	NUM
bibechana-21109	148	8	2000	2000	NUM
bibechana-21109	148	9	3000	3000	NUM
bibechana-21109	148	10	4000no	4000no	NOUN
bibechana-21109	148	11	.	.	PUNCT
bibechana-21109	149	1	of	of	ADP
bibechana-21109	149	2	h	h	NOUN
bibechana-21109	149	3	-	-	PUNCT
bibechana-21109	149	4	bonds	bond	NOUN
bibechana-21109	149	5	frame	frame	NOUN
bibechana-21109	149	6	order	order	NOUN
bibechana-21109	149	7	(	(	PUNCT
bibechana-21109	149	8	0.5ps	0.5ps	NOUN
bibechana-21109	149	9	/	/	SYM
bibechana-21109	149	10	frame)i431	frame)i431	NOUN
bibechana-21109	149	11	-	-	PUNCT
bibechana-21109	149	12	thr(wt	thr(wt	NOUN
bibechana-21109	149	13	)	)	PUNCT
bibechana-21109	149	14	t3	t3	PROPN
bibechana-21109	149	15	-	-	PUNCT
bibechana-21109	149	16	thr(wt	thr(wt	NOUN
bibechana-21109	149	17	)	)	PUNCT
bibechana-21109	149	18	05101520253035	05101520253035	NUM
bibechana-21109	149	19	0	0	NUM
bibechana-21109	150	1	1000	1000	NUM
bibechana-21109	150	2	2000	2000	NUM
bibechana-21109	150	3	3000	3000	NUM
bibechana-21109	150	4	4000no.of	4000no.of	NOUN
bibechana-21109	150	5	h	h	NOUN
bibechana-21109	150	6	-	-	PUNCT
bibechana-21109	150	7	bonds	bond	NOUN
bibechana-21109	150	8	frame	frame	NOUN
bibechana-21109	150	9	order	order	NOUN
bibechana-21109	150	10	(	(	PUNCT
bibechana-21109	150	11	0.5ps	0.5ps	NOUN
bibechana-21109	150	12	/	/	SYM
bibechana-21109	150	13	frame)i431v	frame)i431v	NOUN
bibechana-21109	150	14	-	-	PUNCT
bibechana-21109	150	15	thr(mt	thr(mt	NOUN
bibechana-21109	150	16	)	)	PUNCT
bibechana-21109	150	17	t3	t3	NOUN
bibechana-21109	150	18	-	-	PUNCT
bibechana-21109	150	19	thr(mt	thr(mt	NOUN
bibechana-21109	150	20	)	)	PUNCT
bibechana-21109	150	21	-1.5	-1.5	NUM
bibechana-21109	150	22	-	-	PUNCT
bibechana-21109	150	23	1	1	NUM
bibechana-21109	150	24	-	-	SYM
bibechana-21109	150	25	0.500.5	0.500.5	NUM
bibechana-21109	150	26	0	0	NUM
bibechana-21109	150	27	1000	1000	NUM
bibechana-21109	150	28	2000	2000	NUM
bibechana-21109	150	29	3000	3000	NUM
bibechana-21109	150	30	4000energy	4000energy	NUM
bibechana-21109	150	31	(	(	PUNCT
bibechana-21109	150	32	kcal	kcal	PROPN
bibechana-21109	150	33	/	/	SYM
bibechana-21109	150	34	mol	mol	NOUN
bibechana-21109	150	35	)	)	PUNCT
bibechana-21109	150	36	frame	frame	NOUN
bibechana-21109	150	37	order	order	NOUN
bibechana-21109	150	38	(	(	PUNCT
bibechana-21109	150	39	0.5ps	0.5ps	NUM
bibechana-21109	150	40	/	/	SYM
bibechana-21109	150	41	frame)elec	frame)elec	PROPN
bibechana-21109	150	42	vdw	vdw	NOUN
bibechana-21109	150	43	-1	-1	ADJ
bibechana-21109	150	44	-	-	PUNCT
bibechana-21109	150	45	0.500.51	0.500.51	NOUN
bibechana-21109	150	46	0	0	NUM
bibechana-21109	150	47	1000	1000	NUM
bibechana-21109	150	48	2000	2000	NUM
bibechana-21109	150	49	3000	3000	NUM
bibechana-21109	150	50	4000energy	4000energy	NUM
bibechana-21109	150	51	(	(	PUNCT
bibechana-21109	150	52	kcal	kcal	ADJ
bibechana-21109	150	53	/	/	SYM
bibechana-21109	150	54	mole	mole	ADJ
bibechana-21109	150	55	)	)	PUNCT
bibechana-21109	150	56	frame	frame	NOUN
bibechana-21109	150	57	order	order	NOUN
bibechana-21109	150	58	(	(	PUNCT
bibechana-21109	150	59	0.5ps	0.5ps	NUM
bibechana-21109	150	60	/	/	SYM
bibechana-21109	150	61	frame)elec	frame)elec	NOUN
bibechana-21109	150	62	vdwtika	vdwtika	NOUN
bibechana-21109	150	63	ram	ram	NOUN
bibechana-21109	150	64	lamichhane	lamichhane	NOUN
bibechana-21109	150	65	et	et	PROPN
bibechana-21109	150	66	al./	al./	ADV
bibechana-21109	150	67	bibechana	bibechana	PROPN
bibechana-21109	150	68	16	16	NUM
bibechana-21109	150	69	(	(	PUNCT
bibechana-21109	150	70	2019	2019	NUM
bibechana-21109	150	71	)	)	PUNCT
bibechana-21109	150	72	79	79	NUM
bibechana-21109	150	73	-	-	SYM
bibechana-21109	150	74	91	91	NUM
bibechana-21109	150	75	:	:	PUNCT
bibechana-21109	150	76	rcost	rcost	NOUN
bibechana-21109	150	77	p.87	p.87	PROPN
bibechana-21109	150	78	(	(	PUNCT
bibechana-21109	150	79	online	online	ADJ
bibechana-21109	150	80	publication	publication	NOUN
bibechana-21109	150	81	:	:	PUNCT
bibechana-21109	150	82	dec	dec	PROPN
bibechana-21109	150	83	.	.	PROPN
bibechana-21109	150	84	,	,	PUNCT
bibechana-21109	150	85	2018	2018	NUM
bibechana-21109	150	86	)	)	PUNCT
bibechana-21109	150	87	over	over	ADP
bibechana-21109	150	88	the	the	DET
bibechana-21109	150	89	time	time	NOUN
bibechana-21109	150	90	frames	frame	NOUN
bibechana-21109	150	91	from	from	ADP
bibechana-21109	150	92	500	500	NUM
bibechana-21109	150	93	to	to	ADP
bibechana-21109	150	94	4013	4013	NUM
bibechana-21109	150	95	.	.	PUNCT
bibechana-21109	151	1	the	the	DET
bibechana-21109	151	2	average	average	ADJ
bibechana-21109	151	3	values	value	NOUN
bibechana-21109	151	4	of	of	ADP
bibechana-21109	151	5	electrostatic	electrostatic	ADJ
bibechana-21109	151	6	and	and	CCONJ
bibechana-21109	151	7	van	van	PROPN
bibechana-21109	151	8	der	der	NOUN
bibechana-21109	151	9	waals	waal	NOUN
bibechana-21109	151	10	interaction	interaction	NOUN
bibechana-21109	151	11	energy	energy	NOUN
bibechana-21109	151	12	(	(	PUNCT
bibechana-21109	151	13	from	from	ADP
bibechana-21109	151	14	namd	namd	ADJ
bibechana-21109	151	15	-	-	PUNCT
bibechana-21109	151	16	energy	energy	NOUN
bibechana-21109	151	17	-	-	PUNCT
bibechana-21109	151	18	gui	gui	NOUN
bibechana-21109	151	19	using	use	VERB
bibechana-21109	151	20	switching	switching	NOUN
bibechana-21109	151	21	and	and	CCONJ
bibechana-21109	151	22	cut	cut	VERB
bibechana-21109	151	23	-	-	PUNCT
bibechana-21109	151	24	off	off	ADP
bibechana-21109	151	25	distances	distance	NOUN
bibechana-21109	151	26	of	of	ADP
bibechana-21109	151	27	10	10	NUM
bibechana-21109	151	28	å	å	NOUN
bibechana-21109	151	29	and	and	CCONJ
bibechana-21109	151	30	12	12	NUM
bibechana-21109	151	31	å	å	PROPN
bibechana-21109	151	32	,	,	PUNCT
bibechana-21109	151	33	respectively	respectively	ADV
bibechana-21109	151	34	)	)	PUNCT
bibechana-21109	151	35	with	with	ADP
bibechana-21109	151	36	their	their	PRON
bibechana-21109	151	37	standard	standard	ADJ
bibechana-21109	151	38	deviations	deviation	NOUN
bibechana-21109	151	39	are	be	AUX
bibechana-21109	151	40	-0.25	-0.25	NUM
bibechana-21109	151	41	±	±	NUM
bibechana-21109	151	42	0.17	0.17	NUM
bibechana-21109	151	43	kcal	kcal	NOUN
bibechana-21109	151	44	/	/	SYM
bibechana-21109	151	45	mol	mol	PROPN
bibechana-21109	152	1	and	and	CCONJ
bibechana-21109	152	2	-0.18	-0.18	NUM
bibechana-21109	152	3	±	±	NUM
bibechana-21109	152	4	0.07	0.07	NUM
bibechana-21109	152	5	kcal	kcal	NOUN
bibechana-21109	152	6	/	/	SYM
bibechana-21109	152	7	mol	mol	NOUN
bibechana-21109	152	8	between	between	ADP
bibechana-21109	152	9	i431	i431	PROPN
bibechana-21109	152	10	and	and	CCONJ
bibechana-21109	152	11	t3	t3	PROPN
bibechana-21109	152	12	of	of	ADP
bibechana-21109	152	13	thrt3	thrt3	PROPN
bibechana-21109	152	14	-	-	PUNCT
bibechana-21109	152	15	wt	wt	PROPN
bibechana-21109	152	16	and	and	CCONJ
bibechana-21109	152	17	0.21	0.21	NUM
bibechana-21109	152	18	±	±	NUM
bibechana-21109	152	19	0.08	0.08	NUM
bibechana-21109	152	20	kcal	kcal	NOUN
bibechana-21109	152	21	/	/	SYM
bibechana-21109	152	22	mol	mol	PROPN
bibechana-21109	152	23	and	and	CCONJ
bibechana-21109	152	24	-0.07	-0.07	NUM
bibechana-21109	152	25	±	±	NUM
bibechana-21109	152	26	0.05	0.05	NUM
bibechana-21109	152	27	kcal	kcal	NOUN
bibechana-21109	152	28	/	/	SYM
bibechana-21109	152	29	mol	mol	NOUN
bibechana-21109	152	30	between	between	ADP
bibechana-21109	152	31	i431v	i431v	PROPN
bibechana-21109	152	32	and	and	CCONJ
bibechana-21109	152	33	t3	t3	PROPN
bibechana-21109	152	34	of	of	ADP
bibechana-21109	152	35	thrt3	thrt3	PROPN
bibechana-21109	152	36	-	-	PUNCT
bibechana-21109	152	37	mt	mt	PROPN
bibechana-21109	152	38	,	,	PUNCT
bibechana-21109	152	39	respectively	respectively	ADV
bibechana-21109	152	40	.	.	PUNCT
bibechana-21109	153	1	thus	thus	ADV
bibechana-21109	153	2	,	,	PUNCT
bibechana-21109	153	3	the	the	DET
bibechana-21109	153	4	electrostatic	electrostatic	ADJ
bibechana-21109	153	5	energy	energy	NOUN
bibechana-21109	153	6	between	between	ADP
bibechana-21109	153	7	i431	i431	PROPN
bibechana-21109	153	8	and	and	CCONJ
bibechana-21109	153	9	t3	t3	PROPN
bibechana-21109	153	10	in	in	ADP
bibechana-21109	153	11	thrt3	thrt3	PROPN
bibechana-21109	153	12	-	-	PUNCT
bibechana-21109	153	13	wt	wt	PROPN
bibechana-21109	153	14	is	be	AUX
bibechana-21109	153	15	negative	negative	ADJ
bibechana-21109	153	16	and	and	CCONJ
bibechana-21109	153	17	more	more	ADV
bibechana-21109	153	18	fluctuating	fluctuating	NOUN
bibechana-21109	153	19	and	and	CCONJ
bibechana-21109	153	20	that	that	SCONJ
bibechana-21109	153	21	between	between	ADP
bibechana-21109	153	22	i431v	i431v	PROPN
bibechana-21109	153	23	and	and	CCONJ
bibechana-21109	153	24	t3	t3	PROPN
bibechana-21109	153	25	in	in	ADP
bibechana-21109	153	26	thrt3	thrt3	PROPN
bibechana-21109	153	27	-	-	PUNCT
bibechana-21109	153	28	mt	mt	PROPN
bibechana-21109	153	29	is	be	AUX
bibechana-21109	153	30	positive	positive	ADJ
bibechana-21109	153	31	and	and	CCONJ
bibechana-21109	153	32	less	less	ADJ
bibechana-21109	153	33	fluctuating	fluctuating	NOUN
bibechana-21109	153	34	over	over	ADP
bibechana-21109	153	35	the	the	DET
bibechana-21109	153	36	simulation	simulation	NOUN
bibechana-21109	153	37	time	time	NOUN
bibechana-21109	153	38	.	.	PUNCT
bibechana-21109	154	1	(	(	PUNCT
bibechana-21109	154	2	a	a	X
bibechana-21109	154	3	)	)	PUNCT
bibechana-21109	154	4	(	(	PUNCT
bibechana-21109	154	5	b	b	X
bibechana-21109	154	6	)	)	PUNCT
bibechana-21109	154	7	fig	fig	NOUN
bibechana-21109	154	8	.	.	PUNCT
bibechana-21109	155	1	10	10	NUM
bibechana-21109	155	2	:	:	PUNCT
bibechana-21109	155	3	ir	ir	PROPN
bibechana-21109	155	4	spectra	spectra	PROPN
bibechana-21109	155	5	of	of	ADP
bibechana-21109	155	6	(	(	PUNCT
bibechana-21109	155	7	a	a	PRON
bibechana-21109	155	8	)	)	PUNCT
bibechana-21109	155	9	i431	i431	PROPN
bibechana-21109	155	10	residue	residue	NOUN
bibechana-21109	155	11	and	and	CCONJ
bibechana-21109	155	12	t3	t3	NOUN
bibechana-21109	155	13	-	-	PUNCT
bibechana-21109	155	14	hormone	hormone	NOUN
bibechana-21109	155	15	in	in	ADP
bibechana-21109	155	16	wild	wild	ADJ
bibechana-21109	155	17	type	type	NOUN
bibechana-21109	155	18	thrt3	thrt3	PROPN
bibechana-21109	155	19	and	and	CCONJ
bibechana-21109	155	20	(	(	PUNCT
bibechana-21109	155	21	b	b	X
bibechana-21109	155	22	)	)	PUNCT
bibechana-21109	155	23	i431v	i431v	PROPN
bibechana-21109	155	24	-	-	PUNCT
bibechana-21109	155	25	mutant	mutant	NOUN
bibechana-21109	155	26	and	and	CCONJ
bibechana-21109	155	27	t3	t3	NOUN
bibechana-21109	155	28	-	-	PUNCT
bibechana-21109	155	29	hormone	hormone	NOUN
bibechana-21109	155	30	in	in	ADP
bibechana-21109	155	31	mutated	mutate	VERB
bibechana-21109	155	32	thrt3	thrt3	PROPN
bibechana-21109	155	33	.	.	PUNCT
bibechana-21109	156	1	(	(	PUNCT
bibechana-21109	156	2	a	a	X
bibechana-21109	156	3	)	)	PUNCT
bibechana-21109	156	4	(	(	PUNCT
bibechana-21109	156	5	b	b	X
bibechana-21109	156	6	)	)	PUNCT
bibechana-21109	156	7	fig	fig	NOUN
bibechana-21109	156	8	.	.	PUNCT
bibechana-21109	157	1	11	11	NUM
bibechana-21109	157	2	:	:	PUNCT
bibechana-21109	157	3	electrostatic	electrostatic	ADJ
bibechana-21109	157	4	and	and	CCONJ
bibechana-21109	157	5	van	van	PROPN
bibechana-21109	157	6	der	der	NOUN
bibechana-21109	157	7	waals	waal	NOUN
bibechana-21109	157	8	interaction	interaction	NOUN
bibechana-21109	157	9	energies	energy	NOUN
bibechana-21109	157	10	(	(	PUNCT
bibechana-21109	157	11	a	a	X
bibechana-21109	157	12	)	)	PUNCT
bibechana-21109	157	13	between	between	ADP
bibechana-21109	157	14	i431	i431	PROPN
bibechana-21109	157	15	and	and	CCONJ
bibechana-21109	157	16	t3	t3	PROPN
bibechana-21109	157	17	in	in	ADP
bibechana-21109	157	18	wild	wild	ADJ
bibechana-21109	157	19	type	type	NOUN
bibechana-21109	157	20	thrt3	thrt3	PROPN
bibechana-21109	157	21	and	and	CCONJ
bibechana-21109	157	22	(	(	PUNCT
bibechana-21109	157	23	b	b	NOUN
bibechana-21109	157	24	)	)	PUNCT
bibechana-21109	157	25	between	between	ADP
bibechana-21109	157	26	i431v	i431v	PROPN
bibechana-21109	157	27	and	and	CCONJ
bibechana-21109	157	28	t3	t3	PROPN
bibechana-21109	157	29	in	in	ADP
bibechana-21109	157	30	mutated	mutate	VERB
bibechana-21109	157	31	thrt3	thrt3	PROPN
bibechana-21109	157	32	.	.	PUNCT
bibechana-21109	158	1	internal	internal	ADJ
bibechana-21109	158	2	energy	energy	NOUN
bibechana-21109	158	3	of	of	ADP
bibechana-21109	158	4	the	the	DET
bibechana-21109	158	5	biomolecular	biomolecular	ADJ
bibechana-21109	158	6	system	system	NOUN
bibechana-21109	158	7	is	be	AUX
bibechana-21109	158	8	the	the	DET
bibechana-21109	158	9	sum	sum	NOUN
bibechana-21109	158	10	of	of	ADP
bibechana-21109	158	11	bonding	bonding	NOUN
bibechana-21109	158	12	and	and	CCONJ
bibechana-21109	158	13	non	non	ADJ
bibechana-21109	158	14	-	-	ADJ
bibechana-21109	158	15	bonding	bonding	ADJ
bibechana-21109	158	16	potentials	potential	NOUN
bibechana-21109	158	17	.	.	PUNCT
bibechana-21109	159	1	coulomb	coulomb	NOUN
bibechana-21109	159	2	energy	energy	NOUN
bibechana-21109	159	3	is	be	AUX
bibechana-21109	159	4	the	the	DET
bibechana-21109	159	5	largest	large	ADJ
bibechana-21109	159	6	and	and	CCONJ
bibechana-21109	159	7	its	its	PRON
bibechana-21109	159	8	fluctuation	fluctuation	NOUN
bibechana-21109	159	9	during	during	ADP
bibechana-21109	159	10	smd	smd	NOUN
bibechana-21109	159	11	makes	make	VERB
bibechana-21109	159	12	the	the	DET
bibechana-21109	159	13	total	total	ADJ
bibechana-21109	159	14	internal	internal	ADJ
bibechana-21109	159	15	energy	energy	NOUN
bibechana-21109	159	16	fluctuate	fluctuate	NOUN
bibechana-21109	159	17	about	about	ADP
bibechana-21109	159	18	its	its	PRON
bibechana-21109	159	19	mean	mean	ADJ
bibechana-21109	159	20	value	value	NOUN
bibechana-21109	159	21	.	.	PUNCT
bibechana-21109	160	1	using	use	VERB
bibechana-21109	160	2	namd	namd	ADJ
bibechana-21109	160	3	-	-	PUNCT
bibechana-21109	160	4	energy	energy	NOUN
bibechana-21109	160	5	-	-	PUNCT
bibechana-21109	160	6	gui	gui	NOUN
bibechana-21109	160	7	with	with	ADP
bibechana-21109	160	8	switching	switching	NOUN
bibechana-21109	160	9	and	and	CCONJ
bibechana-21109	160	10	cut	cut	VERB
bibechana-21109	160	11	-	-	PUNCT
bibechana-21109	160	12	off	off	ADP
bibechana-21109	160	13	distances	distance	NOUN
bibechana-21109	160	14	of	of	ADP
bibechana-21109	160	15	10	10	NUM
bibechana-21109	160	16	å	å	NOUN
bibechana-21109	160	17	and	and	CCONJ
bibechana-21109	160	18	12	12	NUM
bibechana-21109	160	19	å	å	PROPN
bibechana-21109	160	20	,	,	PUNCT
bibechana-21109	160	21	the	the	DET
bibechana-21109	160	22	internal	internal	ADJ
bibechana-21109	160	23	energy	energy	NOUN
bibechana-21109	160	24	of	of	ADP
bibechana-21109	160	25	431	431	NUM
bibechana-21109	160	26	-	-	PUNCT
bibechana-21109	160	27	residue	residue	NOUN
bibechana-21109	160	28	,	,	PUNCT
bibechana-21109	160	29	bounded	bound	VERB
bibechana-21109	160	30	t3	t3	NOUN
bibechana-21109	160	31	-	-	PUNCT
bibechana-21109	160	32	hormone	hormone	NOUN
bibechana-21109	160	33	and	and	CCONJ
bibechana-21109	160	34	protein	protein	NOUN
bibechana-21109	160	35	of	of	ADP
bibechana-21109	160	36	thr	thr	PROPN
bibechana-21109	160	37	-	-	PUNCT
bibechana-21109	160	38	wt	wt	NOUN
bibechana-21109	160	39	,	,	PUNCT
bibechana-21109	160	40	thrt3	thrt3	NOUN
bibechana-21109	160	41	-	-	PUNCT
bibechana-21109	160	42	wt	wt	NOUN
bibechana-21109	160	43	and	and	CCONJ
bibechana-21109	160	44	thrt3	thrt3	PROPN
bibechana-21109	160	45	-	-	PUNCT
bibechana-21109	160	46	mt	mt	PROPN
bibechana-21109	160	47	are	be	AUX
bibechana-21109	160	48	calculated	calculate	VERB
bibechana-21109	160	49	and	and	CCONJ
bibechana-21109	160	50	the	the	DET
bibechana-21109	160	51	average	average	ADJ
bibechana-21109	160	52	values	value	NOUN
bibechana-21109	160	53	for	for	ADP
bibechana-21109	160	54	the	the	DET
bibechana-21109	160	55	corresponding	correspond	VERB
bibechana-21109	160	56	systems	system	NOUN
bibechana-21109	160	57	are	be	AUX
bibechana-21109	160	58	listed	list	VERB
bibechana-21109	160	59	in	in	ADP
bibechana-21109	160	60	the	the	DET
bibechana-21109	160	61	table	table	NOUN
bibechana-21109	160	62	2	2	NUM
bibechana-21109	160	63	.	.	PUNCT
bibechana-21109	161	1	the	the	DET
bibechana-21109	161	2	variations	variation	NOUN
bibechana-21109	161	3	of	of	ADP
bibechana-21109	161	4	the	the	DET
bibechana-21109	161	5	related	relate	VERB
bibechana-21109	161	6	internal	internal	ADJ
bibechana-21109	161	7	energy	energy	NOUN
bibechana-21109	161	8	with	with	ADP
bibechana-21109	161	9	respect	respect	NOUN
bibechana-21109	161	10	to	to	ADP
bibechana-21109	161	11	the	the	DET
bibechana-21109	161	12	simulation	simulation	NOUN
bibechana-21109	161	13	time	time	NOUN
bibechana-21109	161	14	are	be	AUX
bibechana-21109	161	15	plotted	plot	VERB
bibechana-21109	161	16	in	in	ADP
bibechana-21109	161	17	the	the	DET
bibechana-21109	161	18	fig	fig	NOUN
bibechana-21109	161	19	.	.	PUNCT
bibechana-21109	162	1	12	12	NUM
bibechana-21109	162	2	.	.	PUNCT
bibechana-21109	163	1	the	the	DET
bibechana-21109	163	2	plots	plot	NOUN
bibechana-21109	163	3	for	for	ADP
bibechana-21109	163	4	the	the	DET
bibechana-21109	163	5	individual	individual	ADJ
bibechana-21109	163	6	potential	potential	ADJ
bibechana-21109	163	7	terms	term	NOUN
bibechana-21109	163	8	show	show	VERB
bibechana-21109	163	9	that	that	SCONJ
bibechana-21109	163	10	the	the	DET
bibechana-21109	163	11	major	major	ADJ
bibechana-21109	163	12	contributor	contributor	NOUN
bibechana-21109	163	13	of	of	ADP
bibechana-21109	163	14	fluctuations	fluctuation	NOUN
bibechana-21109	163	15	in	in	ADP
bibechana-21109	163	16	the	the	DET
bibechana-21109	163	17	internal	internal	ADJ
bibechana-21109	163	18	energy	energy	NOUN
bibechana-21109	163	19	is	be	AUX
bibechana-21109	163	20	the	the	DET
bibechana-21109	163	21	electrostatic	electrostatic	ADJ
bibechana-21109	163	22	energy	energy	NOUN
bibechana-21109	163	23	of	of	ADP
bibechana-21109	163	24	the	the	DET
bibechana-21109	163	25	related	related	ADJ
bibechana-21109	163	26	system	system	NOUN
bibechana-21109	163	27	.	.	PUNCT
bibechana-21109	164	1	204060801001201403500	204060801001201403500	NUM
bibechana-21109	164	2	3600	3600	NUM
bibechana-21109	164	3	3700	3700	NUM
bibechana-21109	164	4	3800	3800	NUM
bibechana-21109	164	5	3900	3900	NUM
bibechana-21109	164	6	4000int	4000int	NOUN
bibechana-21109	164	7	.	.	PUNCT
bibechana-21109	165	1	energy	energy	NOUN
bibechana-21109	165	2	(	(	PUNCT
bibechana-21109	165	3	kcal	kcal	PROPN
bibechana-21109	165	4	/	/	SYM
bibechana-21109	165	5	mol	mol	NOUN
bibechana-21109	165	6	)	)	PUNCT
bibechana-21109	165	7	time	time	NOUN
bibechana-21109	165	8	frame	frame	NOUN
bibechana-21109	165	9	(	(	PUNCT
bibechana-21109	165	10	0.5ps	0.5ps	NOUN
bibechana-21109	165	11	/	/	SYM
bibechana-21109	165	12	frame	frame	NOUN
bibechana-21109	165	13	)	)	PUNCT
bibechana-21109	165	14	i431_thr	i431_thr	PROPN
bibechana-21109	165	15	-	-	PUNCT
bibechana-21109	165	16	wti431_thrt3	wti431_thrt3	PROPN
bibechana-21109	165	17	-	-	PUNCT
bibechana-21109	165	18	wtt3_thrt3	wtt3_thrt3	PROPN
bibechana-21109	165	19	-	-	PUNCT
bibechana-21109	165	20	wti431v_thrt3	wti431v_thrt3	NOUN
bibechana-21109	165	21	-	-	PUNCT
bibechana-21109	165	22	mtt3_thrt3	mtt3_thrt3	PROPN
bibechana-21109	165	23	-	-	PUNCT
bibechana-21109	165	24	mt	mt	NOUN
bibechana-21109	165	25	-1500	-1500	PROPN
bibechana-21109	165	26	-	-	PUNCT
bibechana-21109	165	27	1200	1200	NUM
bibechana-21109	165	28	-	-	PUNCT
bibechana-21109	165	29	900	900	NUM
bibechana-21109	165	30	-	-	PUNCT
bibechana-21109	165	31	600	600	NUM
bibechana-21109	165	32	-	-	NUM
bibechana-21109	165	33	30003500	30003500	NUM
bibechana-21109	165	34	3600	3600	NUM
bibechana-21109	165	35	3700	3700	NUM
bibechana-21109	165	36	3800	3800	NUM
bibechana-21109	165	37	3900	3900	NUM
bibechana-21109	165	38	4000int	4000int	NOUN
bibechana-21109	165	39	.	.	PUNCT
bibechana-21109	166	1	energy	energy	NOUN
bibechana-21109	166	2	(	(	PUNCT
bibechana-21109	166	3	kcal	kcal	PROPN
bibechana-21109	166	4	/	/	SYM
bibechana-21109	166	5	mol	mol	NOUN
bibechana-21109	166	6	)	)	PUNCT
bibechana-21109	166	7	time	time	NOUN
bibechana-21109	166	8	frame	frame	NOUN
bibechana-21109	166	9	(	(	PUNCT
bibechana-21109	166	10	0.5ps	0.5ps	PROPN
bibechana-21109	166	11	/	/	SYM
bibechana-21109	166	12	frame)protein_thr	frame)protein_thr	NOUN
bibechana-21109	166	13	-	-	PUNCT
bibechana-21109	166	14	wt	wt	NOUN
bibechana-21109	166	15	protein_thrt3	protein_thrt3	NOUN
bibechana-21109	166	16	-	-	NOUN
bibechana-21109	166	17	wt	wt	NOUN
bibechana-21109	166	18	protein_thrt3	protein_thrt3	NOUN
bibechana-21109	166	19	-	-	PUNCT
bibechana-21109	166	20	mttika	mttika	NOUN
bibechana-21109	166	21	ram	ram	NOUN
bibechana-21109	166	22	lamichhane	lamichhane	NOUN
bibechana-21109	166	23	et	et	PROPN
bibechana-21109	166	24	al./	al./	ADV
bibechana-21109	166	25	bibechana	bibechana	PROPN
bibechana-21109	166	26	16	16	NUM
bibechana-21109	166	27	(	(	PUNCT
bibechana-21109	166	28	2019	2019	NUM
bibechana-21109	166	29	)	)	PUNCT
bibechana-21109	166	30	79	79	NUM
bibechana-21109	166	31	-	-	SYM
bibechana-21109	166	32	91	91	NUM
bibechana-21109	166	33	:	:	PUNCT
bibechana-21109	166	34	rcost	rcost	NOUN
bibechana-21109	166	35	p.88	p.88	NOUN
bibechana-21109	166	36	(	(	PUNCT
bibechana-21109	166	37	online	online	ADJ
bibechana-21109	166	38	publication	publication	NOUN
bibechana-21109	166	39	:	:	PUNCT
bibechana-21109	167	1	dec	dec	PROPN
bibechana-21109	167	2	.	.	PROPN
bibechana-21109	167	3	,	,	PUNCT
bibechana-21109	167	4	2018	2018	NUM
bibechana-21109	167	5	)	)	PUNCT
bibechana-21109	167	6	table	table	NOUN
bibechana-21109	167	7	2	2	NUM
bibechana-21109	167	8	:	:	PUNCT
bibechana-21109	167	9	internal	internal	ADJ
bibechana-21109	167	10	energy	energy	NOUN
bibechana-21109	167	11	of	of	ADP
bibechana-21109	167	12	the	the	DET
bibechana-21109	167	13	components	component	NOUN
bibechana-21109	167	14	of	of	ADP
bibechana-21109	167	15	unliganded	unligande	VERB
bibechana-21109	167	16	wild	wild	ADJ
bibechana-21109	167	17	type	type	NOUN
bibechana-21109	167	18	,	,	PUNCT
bibechana-21109	167	19	t3	t3	NOUN
bibechana-21109	167	20	-	-	PUNCT
bibechana-21109	167	21	liganded	ligande	VERB
bibechana-21109	167	22	wild	wild	ADJ
bibechana-21109	167	23	type	type	NOUN
bibechana-21109	167	24	and	and	CCONJ
bibechana-21109	167	25	i431v	i431v	PROPN
bibechana-21109	167	26	-	-	PUNCT
bibechana-21109	167	27	mutant	mutant	NOUN
bibechana-21109	167	28	thr	thr	PROPN
bibechana-21109	167	29	-	-	PUNCT
bibechana-21109	167	30	β	β	NOUN
bibechana-21109	167	31	systems	system	NOUN
bibechana-21109	167	32	averaged	average	VERB
bibechana-21109	167	33	over	over	ADP
bibechana-21109	167	34	the	the	DET
bibechana-21109	167	35	values	value	NOUN
bibechana-21109	167	36	from	from	ADP
bibechana-21109	167	37	the	the	DET
bibechana-21109	167	38	last	last	ADJ
bibechana-21109	167	39	0.25	0.25	NUM
bibechana-21109	167	40	ns	ns	NUM
bibechana-21109	167	41	of	of	ADP
bibechana-21109	167	42	their	their	PRON
bibechana-21109	167	43	equilibrations	equilibration	NOUN
bibechana-21109	167	44	where	where	SCONJ
bibechana-21109	167	45	the	the	DET
bibechana-21109	167	46	including	include	VERB
bibechana-21109	167	47	error	error	NOUN
bibechana-21109	167	48	represents	represent	VERB
bibechana-21109	167	49	standard	standard	ADJ
bibechana-21109	167	50	deviation	deviation	NOUN
bibechana-21109	167	51	of	of	ADP
bibechana-21109	167	52	the	the	DET
bibechana-21109	167	53	data	datum	NOUN
bibechana-21109	167	54	.	.	PUNCT
bibechana-21109	168	1	molecule	molecule	NOUN
bibechana-21109	168	2	thr	thr	PROPN
bibechana-21109	168	3	-	-	PUNCT
bibechana-21109	168	4	wt	wt	NOUN
bibechana-21109	168	5	thrt3	thrt3	NOUN
bibechana-21109	168	6	-	-	PUNCT
bibechana-21109	168	7	wt	wt	NOUN
bibechana-21109	168	8	thrt3	thrt3	PROPN
bibechana-21109	168	9	-	-	PUNCT
bibechana-21109	168	10	mt	mt	PROPN
bibechana-21109	168	11	i431	i431	PROPN
bibechana-21109	168	12	protein	protein	NOUN
bibechana-21109	168	13	i431	i431	PROPN
bibechana-21109	168	14	t3	t3	NOUN
bibechana-21109	168	15	protein	protein	NOUN
bibechana-21109	168	16	i431v	i431v	PROPN
bibechana-21109	168	17	t3	t3	PROPN
bibechana-21109	168	18	protein	protein	NOUN
bibechana-21109	168	19	int	int	NOUN
bibechana-21109	168	20	.	.	PUNCT
bibechana-21109	169	1	energy	energy	NOUN
bibechana-21109	169	2	(	(	PUNCT
bibechana-21109	169	3	kcal	kcal	PROPN
bibechana-21109	169	4	/	/	SYM
bibechana-21109	169	5	mol	mol	PROPN
bibechana-21109	169	6	)	)	PUNCT
bibechana-21109	169	7	42.82	42.82	NUM
bibechana-21109	169	8	±	±	NUM
bibechana-21109	169	9	3.21	3.21	NUM
bibechana-21109	169	10	-822.38	-822.38	PROPN
bibechana-21109	169	11	±	±	NOUN
bibechana-21109	169	12	67.67	67.67	NUM
bibechana-21109	169	13	42.88	42.88	NUM
bibechana-21109	169	14	±	±	NUM
bibechana-21109	169	15	3.18	3.18	NUM
bibechana-21109	169	16	128.73	128.73	NUM
bibechana-21109	169	17	±	±	NUM
bibechana-21109	169	18	4.52	4.52	NUM
bibechana-21109	169	19	-644.21	-644.21	PROPN
bibechana-21109	169	20	±	±	NUM
bibechana-21109	169	21	109.87	109.87	NUM
bibechana-21109	169	22	36.13	36.13	NUM
bibechana-21109	169	23	±	±	NUM
bibechana-21109	169	24	3.07	3.07	NUM
bibechana-21109	169	25	124.41	124.41	NUM
bibechana-21109	169	26	±	±	NUM
bibechana-21109	169	27	4.63	4.63	NUM
bibechana-21109	169	28	-756.54	-756.54	PROPN
bibechana-21109	169	29	±	±	PROPN
bibechana-21109	169	30	104.22	104.22	NUM
bibechana-21109	169	31	(	(	PUNCT
bibechana-21109	169	32	a	a	NOUN
bibechana-21109	169	33	)	)	PUNCT
bibechana-21109	169	34	(	(	PUNCT
bibechana-21109	169	35	b	b	X
bibechana-21109	169	36	)	)	PUNCT
bibechana-21109	169	37	fig	fig	NOUN
bibechana-21109	169	38	.	.	PUNCT
bibechana-21109	170	1	12	12	NUM
bibechana-21109	170	2	:	:	PUNCT
bibechana-21109	170	3	fluctuating	fluctuate	VERB
bibechana-21109	170	4	total	total	ADJ
bibechana-21109	170	5	internal	internal	ADJ
bibechana-21109	170	6	energy	energy	NOUN
bibechana-21109	170	7	along	along	ADP
bibechana-21109	170	8	the	the	DET
bibechana-21109	170	9	frame	frame	NOUN
bibechana-21109	170	10	order	order	NOUN
bibechana-21109	170	11	of	of	ADP
bibechana-21109	170	12	(	(	PUNCT
bibechana-21109	170	13	a	a	X
bibechana-21109	170	14	)	)	PUNCT
bibechana-21109	170	15	i431	i431	PROPN
bibechana-21109	170	16	-	-	PUNCT
bibechana-21109	170	17	residue	residue	NOUN
bibechana-21109	170	18	and	and	CCONJ
bibechana-21109	170	19	t3	t3	NOUN
bibechana-21109	170	20	,	,	PUNCT
bibechana-21109	170	21	and	and	CCONJ
bibechana-21109	170	22	(	(	PUNCT
bibechana-21109	170	23	b	b	X
bibechana-21109	170	24	)	)	PUNCT
bibechana-21109	170	25	thr	thr	NOUN
bibechana-21109	170	26	-	-	PUNCT
bibechana-21109	170	27	proteins	protein	NOUN
bibechana-21109	170	28	for	for	ADP
bibechana-21109	170	29	unliganded	unligande	VERB
bibechana-21109	170	30	as	as	ADV
bibechana-21109	170	31	well	well	ADV
bibechana-21109	170	32	as	as	ADP
bibechana-21109	170	33	t3	t3	NOUN
bibechana-21109	170	34	-	-	PUNCT
bibechana-21109	170	35	liganded	ligande	VERB
bibechana-21109	170	36	wild	wild	ADJ
bibechana-21109	170	37	type	type	NOUN
bibechana-21109	170	38	and	and	CCONJ
bibechana-21109	170	39	i431v	i431v	PROPN
bibechana-21109	170	40	-	-	PUNCT
bibechana-21109	170	41	muatant	muatant	NOUN
bibechana-21109	170	42	thr	thr	PROPN
bibechana-21109	170	43	-	-	PUNCT
bibechana-21109	170	44	β	β	NOUN
bibechana-21109	170	45	systems	system	NOUN
bibechana-21109	170	46	in	in	ADP
bibechana-21109	170	47	the	the	DET
bibechana-21109	170	48	last	last	ADJ
bibechana-21109	170	49	0.25	0.25	NUM
bibechana-21109	170	50	ns	ns	NUM
bibechana-21109	170	51	of	of	ADP
bibechana-21109	170	52	their	their	PRON
bibechana-21109	170	53	equilibrations	equilibration	NOUN
bibechana-21109	170	54	.	.	PUNCT
bibechana-21109	171	1	4	4	X
bibechana-21109	171	2	.	.	X
bibechana-21109	171	3	conclusion	conclusion	NOUN
bibechana-21109	171	4	conformational	conformational	ADJ
bibechana-21109	171	5	properties	property	NOUN
bibechana-21109	171	6	and	and	CCONJ
bibechana-21109	171	7	interactions	interaction	NOUN
bibechana-21109	171	8	of	of	ADP
bibechana-21109	171	9	mutational	mutational	ADJ
bibechana-21109	171	10	residues	residue	NOUN
bibechana-21109	171	11	and	and	CCONJ
bibechana-21109	171	12	t3	t3	NOUN
bibechana-21109	171	13	-	-	PUNCT
bibechana-21109	171	14	hormone	hormone	NOUN
bibechana-21109	171	15	of	of	ADP
bibechana-21109	171	16	unliganded	unliganded	ADJ
bibechana-21109	171	17	and	and	CCONJ
bibechana-21109	171	18	t3	t3	NOUN
bibechana-21109	171	19	-	-	PUNCT
bibechana-21109	171	20	liganded	ligande	VERB
bibechana-21109	171	21	thyroid	thyroid	NOUN
bibechana-21109	171	22	hormone	hormone	NOUN
bibechana-21109	171	23	receptor	receptor	NOUN
bibechana-21109	171	24	-	-	PUNCT
bibechana-21109	171	25	beta	beta	NOUN
bibechana-21109	171	26	(	(	PUNCT
bibechana-21109	171	27	thr	thr	NOUN
bibechana-21109	171	28	-	-	PUNCT
bibechana-21109	171	29	β	β	NOUN
bibechana-21109	171	30	)	)	PUNCT
bibechana-21109	171	31	can	can	AUX
bibechana-21109	171	32	be	be	AUX
bibechana-21109	171	33	studied	study	VERB
bibechana-21109	171	34	by	by	ADP
bibechana-21109	171	35	means	mean	NOUN
bibechana-21109	171	36	of	of	ADP
bibechana-21109	171	37	molecular	molecular	ADJ
bibechana-21109	171	38	dynamics	dynamic	NOUN
bibechana-21109	171	39	simulations	simulation	NOUN
bibechana-21109	171	40	(	(	PUNCT
bibechana-21109	171	41	mds	mds	PROPN
bibechana-21109	171	42	)	)	PUNCT
bibechana-21109	171	43	.	.	PUNCT
bibechana-21109	172	1	the	the	DET
bibechana-21109	172	2	almost	almost	ADV
bibechana-21109	172	3	constant	constant	ADJ
bibechana-21109	172	4	values	value	NOUN
bibechana-21109	172	5	of	of	ADP
bibechana-21109	172	6	root	root	NOUN
bibechana-21109	172	7	mean	mean	ADJ
bibechana-21109	172	8	square	square	ADJ
bibechana-21109	172	9	deviation	deviation	NOUN
bibechana-21109	172	10	(	(	PUNCT
bibechana-21109	172	11	rmsd	rmsd	VERB
bibechana-21109	172	12	≈	≈	PROPN
bibechana-21109	172	13	2	2	NUM
bibechana-21109	172	14	å	å	NOUN
bibechana-21109	172	15	)	)	PUNCT
bibechana-21109	172	16	and	and	CCONJ
bibechana-21109	172	17	radius	radius	NOUN
bibechana-21109	172	18	of	of	ADP
bibechana-21109	172	19	gyration	gyration	NOUN
bibechana-21109	172	20	(	(	PUNCT
bibechana-21109	172	21	rg	rg	PROPN
bibechana-21109	172	22	≈	≈	PROPN
bibechana-21109	172	23	19	19	NUM
bibechana-21109	172	24	å	å	NOUN
bibechana-21109	172	25	)	)	PUNCT
bibechana-21109	172	26	of	of	ADP
bibechana-21109	172	27	native	native	ADJ
bibechana-21109	172	28	and	and	CCONJ
bibechana-21109	172	29	i431	i431	PROPN
bibechana-21109	172	30	-	-	PUNCT
bibechana-21109	172	31	mutant	mutant	NOUN
bibechana-21109	172	32	thr	thr	PROPN
bibechana-21109	172	33	-	-	PUNCT
bibechana-21109	172	34	β	β	NOUN
bibechana-21109	172	35	proteins	protein	NOUN
bibechana-21109	172	36	show	show	VERB
bibechana-21109	172	37	their	their	PRON
bibechana-21109	172	38	conformational	conformational	ADJ
bibechana-21109	172	39	stability	stability	NOUN
bibechana-21109	172	40	during	during	ADP
bibechana-21109	172	41	mds	mds	PROPN
bibechana-21109	172	42	.	.	PUNCT
bibechana-21109	173	1	the	the	DET
bibechana-21109	173	2	native	native	ADJ
bibechana-21109	173	3	i431	i431	PROPN
bibechana-21109	173	4	-	-	PUNCT
bibechana-21109	173	5	residue	residue	NOUN
bibechana-21109	173	6	has	have	AUX
bibechana-21109	173	7	largely	largely	ADV
bibechana-21109	173	8	fluctuating	fluctuate	VERB
bibechana-21109	173	9	rmsd	rmsd	NOUN
bibechana-21109	173	10	and	and	CCONJ
bibechana-21109	173	11	rg	rg	PROPN
bibechana-21109	173	12	showing	show	VERB
bibechana-21109	173	13	its	its	PRON
bibechana-21109	173	14	dynamic	dynamic	ADJ
bibechana-21109	173	15	property	property	NOUN
bibechana-21109	173	16	in	in	ADP
bibechana-21109	173	17	adapting	adapt	VERB
bibechana-21109	173	18	and	and	CCONJ
bibechana-21109	173	19	releasing	release	VERB
bibechana-21109	173	20	t3	t3	NOUN
bibechana-21109	173	21	-	-	PUNCT
bibechana-21109	173	22	hormone	hormone	NOUN
bibechana-21109	173	23	.	.	PUNCT
bibechana-21109	174	1	the	the	DET
bibechana-21109	174	2	experimentally	experimentally	ADV
bibechana-21109	174	3	verified	verify	VERB
bibechana-21109	174	4	i431v	i431v	PROPN
bibechana-21109	174	5	mutation	mutation	NOUN
bibechana-21109	174	6	on	on	ADP
bibechana-21109	174	7	thr	thr	PROPN
bibechana-21109	174	8	-	-	PUNCT
bibechana-21109	174	9	β	β	NOUN
bibechana-21109	174	10	gene	gene	NOUN
bibechana-21109	174	11	(	(	PUNCT
bibechana-21109	174	12	ferreira	ferreira	PROPN
bibechana-21109	174	13	et	et	PROPN
bibechana-21109	174	14	al	al	PROPN
bibechana-21109	174	15	.	.	PROPN
bibechana-21109	174	16	,	,	PUNCT
bibechana-21109	174	17	2010	2010	NUM
bibechana-21109	174	18	)	)	PUNCT
bibechana-21109	174	19	is	be	AUX
bibechana-21109	174	20	the	the	DET
bibechana-21109	174	21	subject	subject	NOUN
bibechana-21109	174	22	of	of	ADP
bibechana-21109	174	23	this	this	DET
bibechana-21109	174	24	computational	computational	ADJ
bibechana-21109	174	25	study	study	NOUN
bibechana-21109	174	26	.	.	PUNCT
bibechana-21109	175	1	this	this	DET
bibechana-21109	175	2	mutation	mutation	NOUN
bibechana-21109	175	3	causes	cause	VERB
bibechana-21109	175	4	resistance	resistance	NOUN
bibechana-21109	175	5	to	to	PART
bibechana-21109	175	6	thyroid	thyroid	VERB
bibechana-21109	175	7	hormones	hormone	NOUN
bibechana-21109	175	8	[	[	X
bibechana-21109	175	9	12	12	NUM
bibechana-21109	175	10	]	]	PUNCT
bibechana-21109	175	11	.	.	PUNCT
bibechana-21109	176	1	solvent	solvent	ADJ
bibechana-21109	176	2	accessible	accessible	ADJ
bibechana-21109	176	3	surface	surface	NOUN
bibechana-21109	176	4	area	area	NOUN
bibechana-21109	176	5	(	(	PUNCT
bibechana-21109	176	6	sasa	sasa	PROPN
bibechana-21109	176	7	)	)	PUNCT
bibechana-21109	176	8	is	be	AUX
bibechana-21109	176	9	larger	large	ADJ
bibechana-21109	176	10	for	for	SCONJ
bibechana-21109	176	11	the	the	DET
bibechana-21109	176	12	i431v	i431v	PROPN
bibechana-21109	176	13	-	-	PUNCT
bibechana-21109	176	14	mutant	mutant	NOUN
bibechana-21109	176	15	indicating	indicate	VERB
bibechana-21109	176	16	partial	partial	ADJ
bibechana-21109	176	17	unfolding	unfolding	NOUN
bibechana-21109	176	18	of	of	ADP
bibechana-21109	176	19	the	the	DET
bibechana-21109	176	20	globular	globular	ADJ
bibechana-21109	176	21	protein	protein	NOUN
bibechana-21109	176	22	.	.	PUNCT
bibechana-21109	177	1	however	however	ADV
bibechana-21109	177	2	,	,	PUNCT
bibechana-21109	177	3	the	the	DET
bibechana-21109	177	4	root	root	NOUN
bibechana-21109	177	5	mean	mean	VERB
bibechana-21109	177	6	square	square	ADJ
bibechana-21109	177	7	fluctuation	fluctuation	NOUN
bibechana-21109	177	8	of	of	ADP
bibechana-21109	177	9	i431v	i431v	PROPN
bibechana-21109	177	10	-	-	PUNCT
bibechana-21109	177	11	mutant	mutant	NOUN
bibechana-21109	177	12	is	be	AUX
bibechana-21109	177	13	smaller	small	ADJ
bibechana-21109	177	14	in	in	ADP
bibechana-21109	177	15	comparison	comparison	NOUN
bibechana-21109	177	16	with	with	ADP
bibechana-21109	177	17	that	that	PRON
bibechana-21109	177	18	of	of	ADP
bibechana-21109	177	19	native	native	ADJ
bibechana-21109	177	20	wild	wild	ADJ
bibechana-21109	177	21	type	type	NOUN
bibechana-21109	177	22	i431	i431	PROPN
bibechana-21109	177	23	.	.	PUNCT
bibechana-21109	178	1	the	the	DET
bibechana-21109	178	2	sasa	sasa	NOUN
bibechana-21109	178	3	of	of	ADP
bibechana-21109	178	4	t3	t3	PROPN
bibechana-21109	178	5	is	be	AUX
bibechana-21109	178	6	zero	zero	NUM
bibechana-21109	178	7	verifying	verify	VERB
bibechana-21109	178	8	the	the	DET
bibechana-21109	178	9	hydrophobicity	hydrophobicity	NOUN
bibechana-21109	178	10	upon	upon	SCONJ
bibechana-21109	178	11	binding	bind	VERB
bibechana-21109	178	12	to	to	ADP
bibechana-21109	178	13	the	the	DET
bibechana-21109	178	14	ligand	ligand	ADJ
bibechana-21109	178	15	binding	bind	VERB
bibechana-21109	178	16	domain	domain	NOUN
bibechana-21109	178	17	(	(	PUNCT
bibechana-21109	178	18	lbd	lbd	PROPN
bibechana-21109	178	19	)	)	PUNCT
bibechana-21109	178	20	of	of	ADP
bibechana-21109	178	21	thr	thr	PROPN
bibechana-21109	178	22	-	-	PUNCT
bibechana-21109	178	23	β	β	NOUN
bibechana-21109	178	24	.	.	PUNCT
bibechana-21109	179	1	comparing	compare	VERB
bibechana-21109	179	2	the	the	DET
bibechana-21109	179	3	radial	radial	ADJ
bibechana-21109	179	4	distribution	distribution	NOUN
bibechana-21109	179	5	functions	function	NOUN
bibechana-21109	179	6	g(r	g(r	NOUN
bibechana-21109	179	7	)	)	PUNCT
bibechana-21109	179	8	for	for	ADP
bibechana-21109	179	9	the	the	DET
bibechana-21109	179	10	atomic	atomic	ADJ
bibechana-21109	179	11	particles	particle	NOUN
bibechana-21109	179	12	between	between	ADP
bibechana-21109	179	13	i431	i431	PROPN
bibechana-21109	179	14	and	and	CCONJ
bibechana-21109	179	15	t3	t3	PROPN
bibechana-21109	179	16	as	as	ADV
bibechana-21109	179	17	well	well	ADV
bibechana-21109	179	18	as	as	ADP
bibechana-21109	179	19	i431v	i431v	PROPN
bibechana-21109	179	20	and	and	CCONJ
bibechana-21109	179	21	t3	t3	PROPN
bibechana-21109	179	22	,	,	PUNCT
bibechana-21109	179	23	the	the	DET
bibechana-21109	179	24	probability	probability	NOUN
bibechana-21109	179	25	density	density	NOUN
bibechana-21109	179	26	is	be	AUX
bibechana-21109	179	27	higher	high	ADJ
bibechana-21109	179	28	in	in	ADP
bibechana-21109	179	29	the	the	DET
bibechana-21109	179	30	former	former	ADJ
bibechana-21109	179	31	wild	wild	ADJ
bibechana-21109	179	32	type	type	NOUN
bibechana-21109	179	33	than	than	SCONJ
bibechana-21109	179	34	the	the	DET
bibechana-21109	179	35	latter	latter	ADJ
bibechana-21109	179	36	mutated	mutate	VERB
bibechana-21109	179	37	type	type	NOUN
bibechana-21109	179	38	for	for	ADP
bibechana-21109	179	39	which	which	DET
bibechana-21109	179	40	g(r	g(r	PROPN
bibechana-21109	179	41	)	)	PUNCT
bibechana-21109	179	42	covers	cover	VERB
bibechana-21109	179	43	the	the	DET
bibechana-21109	179	44	distance	distance	NOUN
bibechana-21109	179	45	of	of	ADP
bibechana-21109	179	46	5	5	NUM
bibechana-21109	179	47	å	å	NOUN
bibechana-21109	179	48	to	to	ADP
bibechana-21109	179	49	18	18	NUM
bibechana-21109	179	50	å	å	NOUN
bibechana-21109	179	51	.	.	PUNCT
bibechana-21109	180	1	ir	ir	PROPN
bibechana-21109	180	2	spectral	spectral	ADJ
bibechana-21109	180	3	density	density	NOUN
bibechana-21109	180	4	calculations	calculation	NOUN
bibechana-21109	180	5	for	for	ADP
bibechana-21109	180	6	i431	i431	NOUN
bibechana-21109	180	7	-	-	PUNCT
bibechana-21109	180	8	residue	residue	NOUN
bibechana-21109	180	9	and	and	CCONJ
bibechana-21109	180	10	t3	t3	NOUN
bibechana-21109	180	11	-	-	PUNCT
bibechana-21109	180	12	hormone	hormone	NOUN
bibechana-21109	180	13	in	in	ADP
bibechana-21109	180	14	the	the	DET
bibechana-21109	180	15	frequency	frequency	NOUN
bibechana-21109	180	16	range	range	NOUN
bibechana-21109	180	17	of	of	ADP
bibechana-21109	180	18	0	0	NUM
bibechana-21109	180	19	-	-	SYM
bibechana-21109	180	20	2000	2000	NUM
bibechana-21109	180	21	cm-1	cm-1	VERB
bibechana-21109	180	22	imply	imply	VERB
bibechana-21109	180	23	that	that	SCONJ
bibechana-21109	180	24	greater	great	ADJ
bibechana-21109	180	25	number	number	NOUN
bibechana-21109	180	26	of	of	ADP
bibechana-21109	180	27	intensity	intensity	NOUN
bibechana-21109	180	28	maxima	maxima	NOUN
bibechana-21109	180	29	is	be	AUX
bibechana-21109	180	30	found	find	VERB
bibechana-21109	180	31	in	in	ADP
bibechana-21109	180	32	thrt3	thrt3	PROPN
bibechana-21109	180	33	-	-	PUNCT
bibechana-21109	180	34	mt	mt	PROPN
bibechana-21109	180	35	than	than	ADP
bibechana-21109	180	36	in	in	ADP
bibechana-21109	180	37	thrt3	thrt3	PROPN
bibechana-21109	180	38	-	-	PUNCT
bibechana-21109	180	39	wt	wt	NOUN
bibechana-21109	180	40	.	.	PUNCT
bibechana-21109	181	1	this	this	PRON
bibechana-21109	181	2	signifies	signify	VERB
bibechana-21109	181	3	higher	high	ADJ
bibechana-21109	181	4	dipole	dipole	NOUN
bibechana-21109	181	5	moment	moment	NOUN
bibechana-21109	181	6	distributions	distribution	NOUN
bibechana-21109	181	7	by	by	ADP
bibechana-21109	181	8	supporting	support	VERB
bibechana-21109	181	9	less	less	ADJ
bibechana-21109	181	10	globular	globular	ADJ
bibechana-21109	181	11	stability	stability	NOUN
bibechana-21109	181	12	of	of	ADP
bibechana-21109	181	13	the	the	DET
bibechana-21109	181	14	mutated	mutate	VERB
bibechana-21109	181	15	thr	thr	PROPN
bibechana-21109	181	16	-	-	PUNCT
bibechana-21109	181	17	β	β	PROPN
bibechana-21109	181	18	than	than	ADP
bibechana-21109	181	19	that	that	PRON
bibechana-21109	181	20	of	of	ADP
bibechana-21109	181	21	the	the	DET
bibechana-21109	181	22	wild	wild	ADJ
bibechana-21109	181	23	type	type	NOUN
bibechana-21109	181	24	thr	thr	PROPN
bibechana-21109	181	25	-	-	PUNCT
bibechana-21109	181	26	β	β	NOUN
bibechana-21109	181	27	.	.	PUNCT
bibechana-21109	182	1	furthermore	furthermore	ADV
bibechana-21109	182	2	,	,	PUNCT
bibechana-21109	182	3	electrostatic	electrostatic	ADJ
bibechana-21109	182	4	interaction	interaction	NOUN
bibechana-21109	182	5	energy	energy	NOUN
bibechana-21109	182	6	between	between	ADP
bibechana-21109	182	7	i431v	i431v	PROPN
bibechana-21109	182	8	-	-	PUNCT
bibechana-21109	182	9	mutant	mutant	NOUN
bibechana-21109	182	10	and	and	CCONJ
bibechana-21109	182	11	t3	t3	NOUN
bibechana-21109	182	12	is	be	AUX
bibechana-21109	182	13	positive	positive	ADJ
bibechana-21109	182	14	whereas	whereas	SCONJ
bibechana-21109	182	15	it	it	PRON
bibechana-21109	182	16	is	be	AUX
bibechana-21109	182	17	negative	negative	ADJ
bibechana-21109	182	18	between	between	ADP
bibechana-21109	182	19	tika	tika	X
bibechana-21109	182	20	ram	ram	NOUN
bibechana-21109	182	21	lamichhane	lamichhane	NOUN
bibechana-21109	182	22	et	et	PROPN
bibechana-21109	182	23	al./	al./	ADV
bibechana-21109	182	24	bibechana	bibechana	PROPN
bibechana-21109	182	25	16	16	NUM
bibechana-21109	182	26	(	(	PUNCT
bibechana-21109	182	27	2019	2019	NUM
bibechana-21109	182	28	)	)	PUNCT
bibechana-21109	182	29	79	79	NUM
bibechana-21109	182	30	-	-	SYM
bibechana-21109	182	31	91	91	NUM
bibechana-21109	182	32	:	:	PUNCT
bibechana-21109	182	33	rcost	rcost	NOUN
bibechana-21109	182	34	p.89	p.89	INTJ
bibechana-21109	182	35	(	(	PUNCT
bibechana-21109	182	36	online	online	ADJ
bibechana-21109	182	37	publication	publication	NOUN
bibechana-21109	182	38	:	:	PUNCT
bibechana-21109	182	39	dec	dec	PROPN
bibechana-21109	182	40	.	.	PROPN
bibechana-21109	182	41	,	,	PUNCT
bibechana-21109	182	42	2018	2018	NUM
bibechana-21109	182	43	)	)	PUNCT
bibechana-21109	182	44	native	native	ADJ
bibechana-21109	182	45	i431	i431	PROPN
bibechana-21109	182	46	-	-	PUNCT
bibechana-21109	182	47	residue	residue	NOUN
bibechana-21109	182	48	and	and	CCONJ
bibechana-21109	182	49	t3	t3	NOUN
bibechana-21109	182	50	.	.	PUNCT
bibechana-21109	183	1	in	in	ADP
bibechana-21109	183	2	this	this	DET
bibechana-21109	183	3	study	study	NOUN
bibechana-21109	183	4	,	,	PUNCT
bibechana-21109	183	5	internal	internal	ADJ
bibechana-21109	183	6	energy	energy	NOUN
bibechana-21109	183	7	of	of	ADP
bibechana-21109	183	8	the	the	DET
bibechana-21109	183	9	native	native	ADJ
bibechana-21109	183	10	i431	i431	PROPN
bibechana-21109	183	11	-	-	PUNCT
bibechana-21109	183	12	residue	residue	NOUN
bibechana-21109	183	13	is	be	AUX
bibechana-21109	183	14	42.88	42.88	NUM
bibechana-21109	183	15	±	±	NUM
bibechana-21109	183	16	3.18	3.18	NUM
bibechana-21109	183	17	kcal	kcal	NOUN
bibechana-21109	183	18	/	/	SYM
bibechana-21109	183	19	mol	mol	PROPN
bibechana-21109	183	20	and	and	CCONJ
bibechana-21109	183	21	that	that	PRON
bibechana-21109	183	22	of	of	ADP
bibechana-21109	183	23	wild	wild	ADJ
bibechana-21109	183	24	type	type	NOUN
bibechana-21109	183	25	i431v	i431v	PROPN
bibechana-21109	183	26	-	-	PUNCT
bibechana-21109	183	27	mutant	mutant	NOUN
bibechana-21109	183	28	is	be	AUX
bibechana-21109	183	29	36.13	36.13	NUM
bibechana-21109	183	30	±	±	NUM
bibechana-21109	183	31	3.07	3.07	NUM
bibechana-21109	183	32	kcal	kcal	NOUN
bibechana-21109	183	33	/	/	SYM
bibechana-21109	183	34	mol	mol	NOUN
bibechana-21109	183	35	in	in	ADP
bibechana-21109	183	36	thrt3	thrt3	PROPN
bibechana-21109	183	37	systems	system	NOUN
bibechana-21109	183	38	.	.	PUNCT
bibechana-21109	184	1	the	the	DET
bibechana-21109	184	2	major	major	ADJ
bibechana-21109	184	3	contributor	contributor	NOUN
bibechana-21109	184	4	of	of	ADP
bibechana-21109	184	5	such	such	ADJ
bibechana-21109	184	6	change	change	NOUN
bibechana-21109	184	7	in	in	ADP
bibechana-21109	184	8	the	the	DET
bibechana-21109	184	9	internal	internal	ADJ
bibechana-21109	184	10	energy	energy	NOUN
bibechana-21109	184	11	is	be	AUX
bibechana-21109	184	12	the	the	DET
bibechana-21109	184	13	electrostatic	electrostatic	ADJ
bibechana-21109	184	14	energy	energy	NOUN
bibechana-21109	184	15	.	.	PUNCT
bibechana-21109	185	1	acknowledgement	acknowledgement	NOUN
bibechana-21109	185	2	this	this	DET
bibechana-21109	185	3	work	work	NOUN
bibechana-21109	185	4	was	be	AUX
bibechana-21109	185	5	partially	partially	ADV
bibechana-21109	185	6	supported	support	VERB
bibechana-21109	185	7	by	by	ADP
bibechana-21109	185	8	nepal	nepal	PROPN
bibechana-21109	185	9	academy	academy	PROPN
bibechana-21109	185	10	of	of	ADP
bibechana-21109	185	11	science	science	NOUN
bibechana-21109	185	12	and	and	CCONJ
bibechana-21109	185	13	technology	technology	NOUN
bibechana-21109	185	14	(	(	PUNCT
bibechana-21109	185	15	nast	nast	ADJ
bibechana-21109	185	16	)	)	PUNCT
bibechana-21109	185	17	as	as	ADP
bibechana-21109	185	18	the	the	DET
bibechana-21109	185	19	ph	ph	PROPN
bibechana-21109	185	20	.	.	PROPN
bibechana-21109	185	21	d.	d.	PROPN
bibechana-21109	185	22	fellowship	fellowship	PROPN
bibechana-21109	185	23	grant	grant	NOUN
bibechana-21109	185	24	to	to	ADP
bibechana-21109	185	25	the	the	DET
bibechana-21109	185	26	first	first	ADJ
bibechana-21109	185	27	author	author	NOUN
bibechana-21109	185	28	.	.	PUNCT
bibechana-21109	186	1	the	the	DET
bibechana-21109	186	2	computing	computing	NOUN
bibechana-21109	186	3	facility	facility	NOUN
bibechana-21109	186	4	was	be	AUX
bibechana-21109	186	5	provided	provide	VERB
bibechana-21109	186	6	by	by	ADP
bibechana-21109	186	7	central	central	ADJ
bibechana-21109	186	8	department	department	PROPN
bibechana-21109	186	9	of	of	ADP
bibechana-21109	186	10	physics	physics	PROPN
bibechana-21109	186	11	,	,	PUNCT
bibechana-21109	186	12	tribhuvan	tribhuvan	PROPN
bibechana-21109	186	13	university	university	PROPN
bibechana-21109	186	14	,	,	PUNCT
bibechana-21109	186	15	kathmandu	kathmandu	NOUN
bibechana-21109	186	16	,	,	PUNCT
bibechana-21109	186	17	nepal	nepal	ADJ
bibechana-21109	186	18	.	.	PUNCT
bibechana-21109	187	1	references	reference	NOUN
bibechana-21109	187	2	[	[	X
bibechana-21109	187	3	1	1	NUM
bibechana-21109	187	4	]	]	PUNCT
bibechana-21109	187	5	l.	l.	PROPN
bibechana-21109	187	6	martínez	martínez	PROPN
bibechana-21109	187	7	,	,	PUNCT
bibechana-21109	187	8	i.	i.	PROPN
bibechana-21109	187	9	polikarpov	polikarpov	PROPN
bibechana-21109	187	10	,	,	PUNCT
bibechana-21109	187	11	m.	m.	NOUN
bibechana-21109	187	12	s.	s.	PROPN
bibechana-21109	187	13	skaf	skaf	PROPN
bibechana-21109	187	14	,	,	PUNCT
bibechana-21109	187	15	only	only	ADV
bibechana-21109	187	16	subtle	subtle	ADJ
bibechana-21109	187	17	protein	protein	NOUN
bibechana-21109	187	18	conformational	conformational	ADJ
bibechana-21109	187	19	adaptations	adaptation	NOUN
bibechana-21109	187	20	are	be	AUX
bibechana-21109	187	21	required	require	VERB
bibechana-21109	187	22	for	for	ADP
bibechana-21109	187	23	ligand	ligand	NOUN
bibechana-21109	187	24	binding	bind	VERB
bibechana-21109	187	25	to	to	PART
bibechana-21109	187	26	thyroid	thyroid	VERB
bibechana-21109	187	27	hormone	hormone	NOUN
bibechana-21109	187	28	receptors	receptor	NOUN
bibechana-21109	187	29	:	:	PUNCT
bibechana-21109	187	30	simulations	simulation	NOUN
bibechana-21109	187	31	using	use	VERB
bibechana-21109	187	32	a	a	DET
bibechana-21109	187	33	novel	novel	ADJ
bibechana-21109	187	34	multipoint	multipoint	NOUN
bibechana-21109	187	35	steered	steer	VERB
bibechana-21109	187	36	molecular	molecular	ADJ
bibechana-21109	187	37	dynamics	dynamic	NOUN
bibechana-21109	187	38	approach	approach	NOUN
bibechana-21109	187	39	,	,	PUNCT
bibechana-21109	187	40	j.	j.	PROPN
bibechana-21109	187	41	phys	phys	PROPN
bibechana-21109	187	42	.	.	PUNCT
bibechana-21109	188	1	chem	chem	PROPN
bibechana-21109	188	2	.	.	PUNCT
bibechana-21109	189	1	b	b	X
bibechana-21109	189	2	112	112	NUM
bibechana-21109	189	3	(	(	PUNCT
bibechana-21109	189	4	2008	2008	NUM
bibechana-21109	189	5	)	)	PUNCT
bibechana-21109	189	6	10741–10751	10741–10751	NUM
bibechana-21109	189	7	.	.	PUNCT
bibechana-21109	190	1	doi.org/10.1021/jp803403c	doi.org/10.1021/jp803403c	PROPN
bibechana-21109	190	2	.	.	PUNCT
bibechana-21109	191	1	[	[	X
bibechana-21109	191	2	2	2	NUM
bibechana-21109	191	3	]	]	PUNCT
bibechana-21109	191	4	l.	l.	PROPN
bibechana-21109	191	5	martínez	martínez	PROPN
bibechana-21109	191	6	,	,	PUNCT
bibechana-21109	191	7	p.	p.	PROPN
bibechana-21109	191	8	c.	c.	PROPN
bibechana-21109	191	9	t.	t.	PROPN
bibechana-21109	191	10	souza	souza	PROPN
bibechana-21109	191	11	,	,	PUNCT
bibechana-21109	191	12	w.	w.	PROPN
bibechana-21109	191	13	garcia	garcia	PROPN
bibechana-21109	191	14	,	,	PUNCT
bibechana-21109	191	15	f.	f.	PROPN
bibechana-21109	191	16	a.	a.	PROPN
bibechana-21109	191	17	batista	batista	PROPN
bibechana-21109	191	18	,	,	PUNCT
bibechana-21109	191	19	r.	r.	PROPN
bibechana-21109	191	20	v.	v.	PROPN
bibechana-21109	191	21	portugal	portugal	PROPN
bibechana-21109	191	22	,	,	PUNCT
bibechana-21109	191	23	a.	a.	PROPN
bibechana-21109	191	24	s.	s.	PROPN
bibechana-21109	191	25	nascimento	nascimento	PROPN
bibechana-21109	191	26	,	,	PUNCT
bibechana-21109	191	27	m.	m.	NOUN
bibechana-21109	191	28	nakahira	nakahira	PROPN
bibechana-21109	191	29	,	,	PUNCT
bibechana-21109	191	30	l.	l.	PROPN
bibechana-21109	191	31	m.	m.	PROPN
bibechana-21109	191	32	lima	lima	PROPN
bibechana-21109	191	33	,	,	PUNCT
bibechana-21109	191	34	i.	i.	PROPN
bibechana-21109	191	35	polikarpov	polikarpov	PROPN
bibechana-21109	191	36	,	,	PUNCT
bibechana-21109	191	37	m.	m.	NOUN
bibechana-21109	191	38	s.	s.	PROPN
bibechana-21109	191	39	skaf	skaf	PROPN
bibechana-21109	191	40	,	,	PUNCT
bibechana-21109	191	41	on	on	ADP
bibechana-21109	191	42	the	the	DET
bibechana-21109	191	43	denaturation	denaturation	NOUN
bibechana-21109	191	44	mechanisms	mechanism	NOUN
bibechana-21109	191	45	of	of	ADP
bibechana-21109	191	46	the	the	DET
bibechana-21109	191	47	ligand	ligand	ADJ
bibechana-21109	191	48	binding	bind	VERB
bibechana-21109	191	49	domain	domain	NOUN
bibechana-21109	191	50	of	of	ADP
bibechana-21109	191	51	thyroid	thyroid	NOUN
bibechana-21109	191	52	hormone	hormone	NOUN
bibechana-21109	191	53	receptors	receptor	NOUN
bibechana-21109	191	54	,	,	PUNCT
bibechana-21109	191	55	j.	j.	PROPN
bibechana-21109	191	56	phys	phys	PROPN
bibechana-21109	191	57	.	.	PUNCT
bibechana-21109	192	1	chem	chem	PROPN
bibechana-21109	192	2	.	.	PUNCT
bibechana-21109	193	1	b	b	X
bibechana-21109	193	2	114	114	NUM
bibechana-21109	193	3	(	(	PUNCT
bibechana-21109	193	4	2010	2010	NUM
bibechana-21109	193	5	)	)	PUNCT
bibechana-21109	193	6	1529–1540	1529–1540	NUM
bibechana-21109	193	7	.	.	PUNCT
bibechana-21109	194	1	doi.org/	doi.org/	ADP
bibechana-21109	194	2	10.1021	10.1021	NUM
bibechana-21109	194	3	/	/	SYM
bibechana-21109	194	4	jp911554p	jp911554p	NOUN
bibechana-21109	194	5	.	.	PUNCT
bibechana-21109	195	1	[	[	X
bibechana-21109	195	2	3	3	NUM
bibechana-21109	195	3	]	]	X
bibechana-21109	195	4	r.	r.	PROPN
bibechana-21109	195	5	l.	l.	PROPN
bibechana-21109	195	6	wagner	wagner	PROPN
bibechana-21109	195	7	,	,	PUNCT
bibechana-21109	195	8	j.	j.	PROPN
bibechana-21109	195	9	w.	w.	PROPN
bibechana-21109	195	10	apriletti	apriletti	PROPN
bibechana-21109	195	11	,	,	PUNCT
bibechana-21109	195	12	m.	m.	PROPN
bibechana-21109	195	13	e.	e.	PROPN
bibechana-21109	195	14	mcgrath	mcgrath	PROPN
bibechana-21109	195	15	,	,	PUNCT
bibechana-21109	195	16	b.	b.	PROPN
bibechana-21109	195	17	l.	l.	PROPN
bibechana-21109	195	18	west	west	PROPN
bibechana-21109	195	19	,	,	PUNCT
bibechana-21109	195	20	j.	j.	PROPN
bibechana-21109	195	21	d.	d.	PROPN
bibechana-21109	195	22	baxter	baxter	PROPN
bibechana-21109	195	23	,	,	PUNCT
bibechana-21109	195	24	r.	r.	PROPN
bibechana-21109	195	25	j.	j.	PROPN
bibechana-21109	195	26	fletterick	fletterick	PROPN
bibechana-21109	195	27	,	,	PUNCT
bibechana-21109	195	28	a	a	DET
bibechana-21109	195	29	structural	structural	ADJ
bibechana-21109	195	30	role	role	NOUN
bibechana-21109	195	31	for	for	ADP
bibechana-21109	195	32	hormone	hormone	NOUN
bibechana-21109	195	33	in	in	ADP
bibechana-21109	195	34	the	the	DET
bibechana-21109	195	35	thyroid	thyroid	NOUN
bibechana-21109	195	36	hormone	hormone	NOUN
bibechana-21109	195	37	receptor	receptor	NOUN
bibechana-21109	195	38	,	,	PUNCT
bibechana-21109	195	39	nature	nature	NOUN
bibechana-21109	195	40	378	378	NUM
bibechana-21109	195	41	(	(	PUNCT
bibechana-21109	195	42	1995	1995	NUM
bibechana-21109	195	43	)	)	PUNCT
bibechana-21109	195	44	690–697.doi.org/0.1038/378690a0	690–697.doi.org/0.1038/378690a0	NOUN
bibechana-21109	195	45	.	.	PUNCT
bibechana-21109	196	1	[	[	X
bibechana-21109	196	2	4	4	NUM
bibechana-21109	196	3	]	]	X
bibechana-21109	196	4	r.	r.	PROPN
bibechana-21109	196	5	v.	v.	PROPN
bibechana-21109	196	6	weatherman	weatherman	PROPN
bibechana-21109	196	7	,	,	PUNCT
bibechana-21109	196	8	r.	r.	PROPN
bibechana-21109	196	9	j.	j.	PROPN
bibechana-21109	196	10	fletterick	fletterick	PROPN
bibechana-21109	196	11	,	,	PUNCT
bibechana-21109	196	12	t.	t.	PROPN
bibechana-21109	196	13	s.	s.	PROPN
bibechana-21109	196	14	scanlan	scanlan	PROPN
bibechana-21109	196	15	,	,	PUNCT
bibechana-21109	196	16	nuclear	nuclear	ADJ
bibechana-21109	196	17	-	-	PUNCT
bibechana-21109	196	18	receptor	receptor	NOUN
bibechana-21109	196	19	ligands	ligand	NOUN
bibechana-21109	196	20	and	and	CCONJ
bibechana-21109	196	21	ligand	ligand	NOUN
bibechana-21109	196	22	-	-	PUNCT
bibechana-21109	196	23	binding	bind	VERB
bibechana-21109	196	24	domains	domain	NOUN
bibechana-21109	196	25	,	,	PUNCT
bibechana-21109	196	26	annu	annu	NOUN
bibechana-21109	196	27	.	.	PUNCT
bibechana-21109	196	28	rev	rev	PROPN
bibechana-21109	196	29	.	.	PROPN
bibechana-21109	196	30	biochem	biochem	PROPN
bibechana-21109	196	31	.	.	PUNCT
bibechana-21109	197	1	68	68	NUM
bibechana-21109	197	2	(	(	PUNCT
bibechana-21109	197	3	1999	1999	NUM
bibechana-21109	197	4	)	)	PUNCT
bibechana-21109	197	5	559–581.doi.org/10.1146/annurev.biochem.68.1.559	559–581.doi.org/10.1146/annurev.biochem.68.1.559	NUM
bibechana-21109	197	6	.	.	PUNCT
bibechana-21109	198	1	[	[	X
bibechana-21109	198	2	5	5	NUM
bibechana-21109	198	3	]	]	PUNCT
bibechana-21109	198	4	b.	b.	PROPN
bibechana-21109	198	5	c.	c.	PROPN
bibechana-21109	198	6	kallenberger	kallenberger	PROPN
bibechana-21109	198	7	,	,	PUNCT
bibechana-21109	198	8	j.	j.	PROPN
bibechana-21109	198	9	d.	d.	PROPN
bibechana-21109	198	10	love	love	PROPN
bibechana-21109	198	11	,	,	PUNCT
bibechana-21109	198	12	v.	v.	PROPN
bibechana-21109	198	13	k.	k.	PROPN
bibechana-21109	198	14	chatterjee	chatterjee	PROPN
bibechana-21109	198	15	,	,	PUNCT
bibechana-21109	198	16	j.	j.	PROPN
bibechana-21109	198	17	w.	w.	PROPN
bibechana-21109	198	18	schwabe	schwabe	PROPN
bibechana-21109	198	19	,	,	PUNCT
bibechana-21109	198	20	a	a	DET
bibechana-21109	198	21	dynamic	dynamic	ADJ
bibechana-21109	198	22	mechanism	mechanism	NOUN
bibechana-21109	198	23	of	of	ADP
bibechana-21109	198	24	nuclear	nuclear	ADJ
bibechana-21109	198	25	receptor	receptor	NOUN
bibechana-21109	198	26	activation	activation	NOUN
bibechana-21109	198	27	and	and	CCONJ
bibechana-21109	198	28	its	its	PRON
bibechana-21109	198	29	perturbation	perturbation	NOUN
bibechana-21109	198	30	in	in	ADP
bibechana-21109	198	31	a	a	DET
bibechana-21109	198	32	human	human	ADJ
bibechana-21109	198	33	disease	disease	NOUN
bibechana-21109	198	34	,	,	PUNCT
bibechana-21109	198	35	nat	nat	PROPN
bibechana-21109	198	36	.	.	PUNCT
bibechana-21109	198	37	struct	struct	NOUN
bibechana-21109	198	38	.	.	PUNCT
bibechana-21109	199	1	biol.10	biol.10	PROPN
bibechana-21109	199	2	(	(	PUNCT
bibechana-21109	199	3	2003	2003	NUM
bibechana-21109	199	4	)	)	PUNCT
bibechana-21109	199	5	136–140.doi.org/10.1038/nsb892	136–140.doi.org/10.1038/nsb892	NUM
bibechana-21109	199	6	.	.	PUNCT
bibechana-21109	200	1	[	[	X
bibechana-21109	200	2	6	6	NUM
bibechana-21109	200	3	]	]	PUNCT
bibechana-21109	200	4	d.	d.	PROPN
bibechana-21109	200	5	forrest	forrest	PROPN
bibechana-21109	200	6	,	,	PUNCT
bibechana-21109	200	7	e.	e.	PROPN
bibechana-21109	200	8	hanebuth	hanebuth	PROPN
bibechana-21109	200	9	,	,	PUNCT
bibechana-21109	200	10	r.	r.	PROPN
bibechana-21109	200	11	j.	j.	PROPN
bibechana-21109	200	12	smeyne	smeyne	PROPN
bibechana-21109	200	13	,	,	PUNCT
bibechana-21109	200	14	n.	n.	PROPN
bibechana-21109	200	15	everds	everd	NOUN
bibechana-21109	200	16	,	,	PUNCT
bibechana-21109	200	17	c.	c.	PROPN
bibechana-21109	200	18	l.	l.	PROPN
bibechana-21109	200	19	stewart	stewart	PROPN
bibechana-21109	200	20	,	,	PUNCT
bibechana-21109	200	21	j.	j.	PROPN
bibechana-21109	200	22	m.	m.	PROPN
bibechana-21109	200	23	wehner	wehner	PROPN
bibechana-21109	200	24	,	,	PUNCT
bibechana-21109	200	25	t.	t.	PROPN
bibechana-21109	200	26	curran	curran	PROPN
bibechana-21109	200	27	,	,	PUNCT
bibechana-21109	200	28	recessive	recessive	ADJ
bibechana-21109	200	29	resistance	resistance	NOUN
bibechana-21109	200	30	to	to	PART
bibechana-21109	200	31	thyroid	thyroid	VERB
bibechana-21109	200	32	hormone	hormone	NOUN
bibechana-21109	200	33	in	in	ADP
bibechana-21109	200	34	mice	mouse	NOUN
bibechana-21109	200	35	lacking	lack	VERB
bibechana-21109	200	36	thyroid	thyroid	NOUN
bibechana-21109	200	37	hormone	hormone	NOUN
bibechana-21109	200	38	receptor	receptor	NOUN
bibechana-21109	200	39	beta	beta	NOUN
bibechana-21109	200	40	:	:	PUNCT
bibechana-21109	200	41	evidence	evidence	NOUN
bibechana-21109	200	42	for	for	ADP
bibechana-21109	200	43	tissue‐specific	tissue‐specific	NOUN
bibechana-21109	200	44	modulation	modulation	NOUN
bibechana-21109	200	45	of	of	ADP
bibechana-21109	200	46	receptor	receptor	NOUN
bibechana-21109	200	47	function	function	NOUN
bibechana-21109	200	48	,	,	PUNCT
bibechana-21109	200	49	embo	embo	NOUN
bibechana-21109	200	50	j.	j.	PROPN
bibechana-21109	200	51	15	15	NUM
bibechana-21109	200	52	(	(	PUNCT
bibechana-21109	200	53	1996	1996	NUM
bibechana-21109	200	54	)	)	PUNCT
bibechana-21109	201	1	3006-3015.doi.org/10.1002/j.1460-2075.1996.tb00664.x	3006-3015.doi.org/10.1002/j.1460-2075.1996.tb00664.x	NUM
bibechana-21109	201	2	.	.	PUNCT
bibechana-21109	202	1	[	[	X
bibechana-21109	202	2	7	7	X
bibechana-21109	202	3	]	]	X
bibechana-21109	202	4	j.	j.	PROPN
bibechana-21109	202	5	h.	h.	PROPN
bibechana-21109	202	6	lee	lee	PROPN
bibechana-21109	202	7	,	,	PUNCT
bibechana-21109	202	8	e.	e.	PROPN
bibechana-21109	202	9	y.	y.	PROPN
bibechana-21109	202	10	kim	kim	PROPN
bibechana-21109	202	11	,	,	PUNCT
bibechana-21109	202	12	resistance	resistance	NOUN
bibechana-21109	202	13	to	to	PART
bibechana-21109	202	14	thyroid	thyroid	VERB
bibechana-21109	202	15	hormone	hormone	NOUN
bibechana-21109	202	16	due	due	ADP
bibechana-21109	202	17	to	to	ADP
bibechana-21109	202	18	a	a	DET
bibechana-21109	202	19	novel	novel	ADJ
bibechana-21109	202	20	mutation	mutation	NOUN
bibechana-21109	202	21	of	of	ADP
bibechana-21109	202	22	thyroid	thyroid	NOUN
bibechana-21109	202	23	hormone	hormone	NOUN
bibechana-21109	202	24	receptor	receptor	NOUN
bibechana-21109	202	25	beta	beta	NOUN
bibechana-21109	202	26	gene	gene	NOUN
bibechana-21109	202	27	,	,	PUNCT
bibechana-21109	202	28	ann	ann	PROPN
bibechana-21109	202	29	.	.	PUNCT
bibechana-21109	202	30	pediatr	pediatr	PROPN
bibechana-21109	202	31	.	.	PROPN
bibechana-21109	202	32	endocrinol	endocrinol	NOUN
bibechana-21109	202	33	.	.	PUNCT
bibechana-21109	203	1	metab.19	metab.19	NOUN
bibechana-21109	203	2	(	(	PUNCT
bibechana-21109	203	3	2014	2014	NUM
bibechana-21109	203	4	)	)	PUNCT
bibechana-21109	203	5	229	229	NUM
bibechana-21109	203	6	-	-	SYM
bibechana-21109	203	7	231	231	NUM
bibechana-21109	203	8	.	.	PUNCT
bibechana-21109	204	1	doi.org/10.6065/apem.2014.19.4.229	doi.org/10.6065/apem.2014.19.4.229	X
bibechana-21109	204	2	.	.	PUNCT
bibechana-21109	205	1	[	[	X
bibechana-21109	205	2	8	8	X
bibechana-21109	205	3	]	]	PUNCT
bibechana-21109	205	4	k.	k.	PROPN
bibechana-21109	205	5	el	el	PROPN
bibechana-21109	205	6	shafie	shafie	PROPN
bibechana-21109	205	7	,	,	PUNCT
bibechana-21109	205	8	a.	a.	NOUN
bibechana-21109	205	9	ouhtit	ouhtit	PROPN
bibechana-21109	205	10	,	,	PUNCT
bibechana-21109	205	11	y.	y.	PROPN
bibechana-21109	205	12	al	al	PROPN
bibechana-21109	205	13	farsi	farsi	PROPN
bibechana-21109	205	14	,	,	PUNCT
bibechana-21109	205	15	a.	a.	PROPN
bibechana-21109	205	16	al	al	PROPN
bibechana-21109	205	17	sayegh	sayegh	PROPN
bibechana-21109	205	18	,	,	PUNCT
bibechana-21109	205	19	m.	m.	PROPN
bibechana-21109	205	20	al	al	PROPN
bibechana-21109	205	21	shafaee	shafaee	PROPN
bibechana-21109	205	22	,	,	PUNCT
bibechana-21109	205	23	a	a	DET
bibechana-21109	205	24	rare	rare	ADJ
bibechana-21109	205	25	thyroid	thyroid	NOUN
bibechana-21109	205	26	hormone	hormone	NOUN
bibechana-21109	205	27	receptor	receptor	NOUN
bibechana-21109	205	28	beta	beta	NOUN
bibechana-21109	205	29	(	(	PUNCT
bibechana-21109	205	30	thrβ	thrβ	NOUN
bibechana-21109	205	31	)	)	PUNCT
bibechana-21109	205	32	gene	gene	NOUN
bibechana-21109	205	33	mutation	mutation	NOUN
bibechana-21109	205	34	in	in	ADP
bibechana-21109	205	35	a	a	DET
bibechana-21109	205	36	15	15	NUM
bibechana-21109	205	37	-	-	PUNCT
bibechana-21109	205	38	year	year	NOUN
bibechana-21109	205	39	-	-	PUNCT
bibechana-21109	205	40	old	old	ADJ
bibechana-21109	205	41	girl	girl	NOUN
bibechana-21109	205	42	with	with	ADP
bibechana-21109	205	43	thyroid	thyroid	NOUN
bibechana-21109	205	44	hormone	hormone	NOUN
bibechana-21109	205	45	resistance	resistance	NOUN
bibechana-21109	205	46	syndrome	syndrome	NOUN
bibechana-21109	205	47	:	:	PUNCT
bibechana-21109	205	48	a	a	DET
bibechana-21109	205	49	case	case	NOUN
bibechana-21109	205	50	report	report	NOUN
bibechana-21109	205	51	,	,	PUNCT
bibechana-21109	205	52	j.	j.	PROPN
bibechana-21109	205	53	med	med	PROPN
bibechana-21109	205	54	.	.	PUNCT
bibechana-21109	206	1	case	case	NOUN
bibechana-21109	206	2	rep	rep	PROPN
bibechana-21109	206	3	.	.	PROPN
bibechana-21109	206	4	8	8	NUM
bibechana-21109	206	5	(	(	PUNCT
bibechana-21109	206	6	2014	2014	NUM
bibechana-21109	206	7	)	)	PUNCT
bibechana-21109	206	8	12	12	NUM
bibechana-21109	206	9	.	.	PUNCT
bibechana-21109	207	1	doi.org/	doi.org/	ADP
bibechana-21109	207	2	10.1186/1752	10.1186/1752	NUM
bibechana-21109	207	3	-	-	SYM
bibechana-21109	207	4	1947	1947	NUM
bibechana-21109	207	5	-	-	SYM
bibechana-21109	207	6	8	8	NUM
bibechana-21109	207	7	-	-	SYM
bibechana-21109	207	8	12	12	NUM
bibechana-21109	207	9	.	.	PUNCT
bibechana-21109	208	1	[	[	X
bibechana-21109	208	2	9	9	NUM
bibechana-21109	208	3	]	]	PUNCT
bibechana-21109	208	4	w.	w.	PROPN
bibechana-21109	208	5	yang	yang	PROPN
bibechana-21109	208	6	,	,	PUNCT
bibechana-21109	208	7	j.	j.	PROPN
bibechana-21109	208	8	yan	yan	PROPN
bibechana-21109	208	9	,	,	PUNCT
bibechana-21109	208	10	y.	y.	PROPN
bibechana-21109	208	11	sang	sing	VERB
bibechana-21109	208	12	,	,	PUNCT
bibechana-21109	208	13	resistance	resistance	NOUN
bibechana-21109	208	14	to	to	PART
bibechana-21109	208	15	thyroid	thyroid	VERB
bibechana-21109	208	16	hormone	hormone	NOUN
bibechana-21109	208	17	caused	cause	VERB
bibechana-21109	208	18	by	by	ADP
bibechana-21109	208	19	a	a	DET
bibechana-21109	208	20	g344r	g344r	PROPN
bibechana-21109	208	21	mutation	mutation	NOUN
bibechana-21109	208	22	of	of	ADP
bibechana-21109	208	23	thyroid	thyroid	NOUN
bibechana-21109	208	24	hormone	hormone	NOUN
bibechana-21109	208	25	receptor	receptor	NOUN
bibechana-21109	208	26	beta	beta	NOUN
bibechana-21109	208	27	gene	gene	NOUN
bibechana-21109	208	28	:	:	PUNCT
bibechana-21109	208	29	a	a	DET
bibechana-21109	208	30	case	case	NOUN
bibechana-21109	208	31	report	report	NOUN
bibechana-21109	208	32	study	study	NOUN
bibechana-21109	208	33	,	,	PUNCT
bibechana-21109	208	34	endocrinol	endocrinol	NOUN
bibechana-21109	208	35	.	.	PUNCT
bibechana-21109	209	1	metab.synd	metab.synd	NUM
bibechana-21109	209	2	.	.	NOUN
bibechana-21109	209	3	5	5	NUM
bibechana-21109	209	4	(	(	PUNCT
bibechana-21109	209	5	2016	2016	NUM
bibechana-21109	209	6	)	)	PUNCT
bibechana-21109	209	7	231.doi.org/10.4172/2161-1017.1000231	231.doi.org/10.4172/2161-1017.1000231	NUM
bibechana-21109	209	8	.	.	PUNCT
bibechana-21109	210	1	[	[	X
bibechana-21109	210	2	10	10	NUM
bibechana-21109	210	3	]	]	X
bibechana-21109	210	4	j.	j.	PROPN
bibechana-21109	210	5	d.	d.	PROPN
bibechana-21109	210	6	safer	safer	PROPN
bibechana-21109	210	7	,	,	PUNCT
bibechana-21109	210	8	m.	m.	NOUN
bibechana-21109	210	9	g.	g.	PROPN
bibechana-21109	210	10	o’connor	o’connor	PROPN
bibechana-21109	210	11	,	,	PUNCT
bibechana-21109	210	12	s.	s.	PROPN
bibechana-21109	210	13	d.	d.	PROPN
bibechana-21109	210	14	colan	colan	PROPN
bibechana-21109	210	15	,	,	PUNCT
bibechana-21109	210	16	s.	s.	PROPN
bibechana-21109	210	17	srinivasan	srinivasan	PROPN
bibechana-21109	210	18	,	,	PUNCT
bibechana-21109	210	19	s.	s.	PROPN
bibechana-21109	210	20	r.	r.	PROPN
bibechana-21109	210	21	tollin	tollin	PROPN
bibechana-21109	210	22	,	,	PUNCT
bibechana-21109	210	23	f.	f.	PROPN
bibechana-21109	210	24	e.	e.	PROPN
bibechana-21109	210	25	wondisford	wondisford	PROPN
bibechana-21109	210	26	,	,	PUNCT
bibechana-21109	210	27	the	the	DET
bibechana-21109	210	28	thyroid	thyroid	NOUN
bibechana-21109	210	29	hormone	hormone	NOUN
bibechana-21109	210	30	receptor	receptor	NOUN
bibechana-21109	210	31	-	-	PUNCT
bibechana-21109	210	32	β	β	NOUN
bibechana-21109	210	33	gene	gene	NOUN
bibechana-21109	210	34	mutation	mutation	NOUN
bibechana-21109	210	35	r383h	r383h	PROPN
bibechana-21109	210	36	is	be	AUX
bibechana-21109	210	37	associated	associate	VERB
bibechana-21109	210	38	with	with	ADP
bibechana-21109	210	39	isolated	isolated	ADJ
bibechana-21109	210	40	central	central	ADJ
bibechana-21109	210	41	resistance	resistance	NOUN
bibechana-21109	210	42	to	to	PART
bibechana-21109	210	43	thyroid	thyroid	VERB
bibechana-21109	210	44	hormone	hormone	NOUN
bibechana-21109	210	45	,	,	PUNCT
bibechana-21109	210	46	j.	j.	PROPN
bibechana-21109	210	47	clin	clin	PROPN
bibechana-21109	210	48	.	.	PUNCT
bibechana-21109	211	1	endocrinol.metab	endocrinol.metab	PROPN
bibechana-21109	211	2	.	.	PROPN
bibechana-21109	212	1	84	84	NUM
bibechana-21109	212	2	(	(	PUNCT
bibechana-21109	212	3	1999	1999	NUM
bibechana-21109	212	4	)	)	PUNCT
bibechana-21109	213	1	3099-3109.doi.org/10.1210/jcem.84.9.5985	3099-3109.doi.org/10.1210/jcem.84.9.5985	NUM
bibechana-21109	213	2	.	.	PUNCT
bibechana-21109	214	1	[	[	X
bibechana-21109	214	2	11	11	NUM
bibechana-21109	214	3	]	]	X
bibechana-21109	214	4	d.	d.	PROPN
bibechana-21109	214	5	s.	s.	PROPN
bibechana-21109	214	6	machado	machado	PROPN
bibechana-21109	214	7	,	,	PUNCT
bibechana-21109	214	8	a.	a.	PROPN
bibechana-21109	214	9	sabet	sabet	PROPN
bibechana-21109	214	10	,	,	PUNCT
bibechana-21109	214	11	l.	l.	PROPN
bibechana-21109	214	12	a.	a.	PROPN
bibechana-21109	214	13	santiago	santiago	PROPN
bibechana-21109	214	14	,	,	PUNCT
bibechana-21109	214	15	a.	a.	PROPN
bibechana-21109	214	16	r.	r.	PROPN
bibechana-21109	214	17	sidhaye	sidhaye	PROPN
bibechana-21109	214	18	,	,	PUNCT
bibechana-21109	214	19	m.	m.	NOUN
bibechana-21109	214	20	i.	i.	PROPN
bibechana-21109	214	21	chiamolera	chiamolera	PROPN
bibechana-21109	214	22	,	,	PUNCT
bibechana-21109	214	23	t.	t.	PROPN
bibechana-21109	214	24	m.	m.	PROPN
bibechana-21109	214	25	ortiga	ortiga	PROPN
bibechana-21109	214	26	-	-	PUNCT
bibechana-21109	214	27	carvalho	carvalho	NOUN
bibechana-21109	214	28	,	,	PUNCT
bibechana-21109	214	29	f.	f.	PROPN
bibechana-21109	214	30	e.	e.	PROPN
bibechana-21109	214	31	wondisford	wondisford	PROPN
bibechana-21109	214	32	,	,	PUNCT
bibechana-21109	214	33	a	a	DET
bibechana-21109	214	34	thyroid	thyroid	NOUN
bibechana-21109	214	35	hormone	hormone	NOUN
bibechana-21109	214	36	receptor	receptor	NOUN
bibechana-21109	214	37	mutation	mutation	NOUN
bibechana-21109	214	38	that	that	PRON
bibechana-21109	214	39	dissociates	dissociate	NOUN
bibechana-21109	214	40	thyroid	thyroid	VERB
bibechana-21109	214	41	hormone	hormone	NOUN
bibechana-21109	214	42	regulation	regulation	NOUN
bibechana-21109	214	43	of	of	ADP
bibechana-21109	214	44	gene	gene	NOUN
bibechana-21109	214	45	expression	expression	NOUN
bibechana-21109	214	46	in	in	ADP
bibechana-21109	214	47	vivo	vivo	NOUN
bibechana-21109	214	48	,	,	PUNCT
bibechana-21109	214	49	pro	pro	ADJ
bibechana-21109	214	50	.	.	PROPN
bibechana-21109	214	51	natl	natl	PROPN
bibechana-21109	214	52	.	.	PUNCT
bibechana-21109	215	1	acad	acad	PROPN
bibechana-21109	215	2	.	.	PUNCT
bibechana-21109	216	1	sci	sci	PROPN
bibechana-21109	216	2	.	.	PROPN
bibechana-21109	217	1	106	106	NUM
bibechana-21109	218	1	(	(	PUNCT
bibechana-21109	218	2	2009	2009	NUM
bibechana-21109	218	3	)	)	PUNCT
bibechana-21109	218	4	9441-9446.doi.org/10.1073/pnas.0903227106	9441-9446.doi.org/10.1073/pnas.0903227106	NUM
bibechana-21109	218	5	.	.	PUNCT
bibechana-21109	219	1	tika	tika	PROPN
bibechana-21109	219	2	ram	ram	PROPN
bibechana-21109	219	3	lamichhane	lamichhane	PROPN
bibechana-21109	219	4	et	et	PROPN
bibechana-21109	219	5	al./	al./	ADV
bibechana-21109	219	6	bibechana	bibechana	PROPN
bibechana-21109	219	7	16	16	NUM
bibechana-21109	219	8	(	(	PUNCT
bibechana-21109	219	9	2019	2019	NUM
bibechana-21109	219	10	)	)	PUNCT
bibechana-21109	219	11	79	79	NUM
bibechana-21109	219	12	-	-	SYM
bibechana-21109	219	13	91	91	NUM
bibechana-21109	219	14	:	:	PUNCT
bibechana-21109	219	15	rcost	rcost	NOUN
bibechana-21109	219	16	p.90	p.90	PROPN
bibechana-21109	219	17	(	(	PUNCT
bibechana-21109	219	18	online	online	ADJ
bibechana-21109	219	19	publication	publication	NOUN
bibechana-21109	219	20	:	:	PUNCT
bibechana-21109	219	21	dec	dec	PROPN
bibechana-21109	219	22	.	.	PROPN
bibechana-21109	219	23	,	,	PUNCT
bibechana-21109	219	24	2018	2018	NUM
bibechana-21109	219	25	)	)	PUNCT
bibechana-21109	220	1	[	[	X
bibechana-21109	220	2	12	12	NUM
bibechana-21109	220	3	]	]	PUNCT
bibechana-21109	220	4	m.	m.	NOUN
bibechana-21109	220	5	ferreira	ferreira	PROPN
bibechana-21109	220	6	azevedo	azevedo	PROPN
bibechana-21109	220	7	,	,	PUNCT
bibechana-21109	220	8	g.	g.	PROPN
bibechana-21109	220	9	b.	b.	PROPN
bibechana-21109	220	10	barra	barra	PROPN
bibechana-21109	220	11	,	,	PUNCT
bibechana-21109	220	12	l.	l.	PROPN
bibechana-21109	220	13	d.	d.	PROPN
bibechana-21109	220	14	d.	d.	PROPN
bibechana-21109	220	15	medeiros	medeiros	PROPN
bibechana-21109	220	16	,	,	PUNCT
bibechana-21109	220	17	l.	l.	PROPN
bibechana-21109	220	18	a.	a.	PROPN
bibechana-21109	220	19	simeoni	simeoni	PROPN
bibechana-21109	220	20	,	,	PUNCT
bibechana-21109	220	21	l.	l.	PROPN
bibechana-21109	220	22	a.	a.	PROPN
bibechana-21109	220	23	naves	naves	PROPN
bibechana-21109	220	24	,	,	PUNCT
bibechana-21109	220	25	f.	f.	PROPN
bibechana-21109	220	26	d.	d.	PROPN
bibechana-21109	220	27	a.	a.	PROPN
bibechana-21109	220	28	r.	r.	PROPN
bibechana-21109	220	29	neves	neves	PROPN
bibechana-21109	220	30	,	,	PUNCT
bibechana-21109	220	31	a	a	DET
bibechana-21109	220	32	novel	novel	ADJ
bibechana-21109	220	33	mutation	mutation	NOUN
bibechana-21109	220	34	of	of	ADP
bibechana-21109	220	35	thyroid	thyroid	NOUN
bibechana-21109	220	36	hormone	hormone	NOUN
bibechana-21109	220	37	receptor	receptor	NOUN
bibechana-21109	220	38	beta	beta	NOUN
bibechana-21109	220	39	(	(	PUNCT
bibechana-21109	220	40	i431v	i431v	PROPN
bibechana-21109	220	41	)	)	PUNCT
bibechana-21109	220	42	impairs	impair	VERB
bibechana-21109	220	43	corepressor	corepressor	NOUN
bibechana-21109	220	44	release	release	NOUN
bibechana-21109	220	45	,	,	PUNCT
bibechana-21109	220	46	and	and	CCONJ
bibechana-21109	220	47	induces	induce	VERB
bibechana-21109	220	48	thyroid	thyroid	NOUN
bibechana-21109	220	49	hormone	hormone	NOUN
bibechana-21109	220	50	resistance	resistance	NOUN
bibechana-21109	220	51	syndrome	syndrome	NOUN
bibechana-21109	220	52	,	,	PUNCT
bibechana-21109	220	53	arq	arq	PROPN
bibechana-21109	220	54	.	.	PUNCT
bibechana-21109	221	1	bras.endocrinol.metab	bras.endocrinol.metab	NOUN
bibechana-21109	221	2	.	.	PUNCT
bibechana-21109	222	1	52	52	NUM
bibechana-21109	222	2	(	(	PUNCT
bibechana-21109	222	3	2008	2008	NUM
bibechana-21109	222	4	)	)	PUNCT
bibechana-21109	222	5	1304	1304	NUM
bibechana-21109	222	6	-	-	SYM
bibechana-21109	222	7	1312	1312	NUM
bibechana-21109	222	8	.	.	PUNCT
bibechana-21109	223	1	doi.org/10.1590/s0004-27302008000800016	doi.org/10.1590/s0004-27302008000800016	ADV
bibechana-21109	223	2	.	.	PUNCT
bibechana-21109	224	1	[	[	X
bibechana-21109	224	2	13	13	NUM
bibechana-21109	224	3	]	]	PUNCT
bibechana-21109	224	4	m.	m.	PROPN
bibechana-21109	224	5	d.	d.	PROPN
bibechana-21109	224	6	rosen	rosen	PROPN
bibechana-21109	224	7	,	,	PUNCT
bibechana-21109	224	8	m.	m.	PROPN
bibechana-21109	224	9	l.	l.	PROPN
bibechana-21109	224	10	privalsky	privalsky	PROPN
bibechana-21109	224	11	,	,	PUNCT
bibechana-21109	224	12	thyroid	thyroid	VERB
bibechana-21109	224	13	hormone	hormone	NOUN
bibechana-21109	224	14	receptor	receptor	NOUN
bibechana-21109	224	15	mutations	mutation	NOUN
bibechana-21109	224	16	in	in	ADP
bibechana-21109	224	17	cancer	cancer	NOUN
bibechana-21109	224	18	and	and	CCONJ
bibechana-21109	224	19	resistance	resistance	NOUN
bibechana-21109	224	20	to	to	PART
bibechana-21109	224	21	thyroid	thyroid	VERB
bibechana-21109	224	22	hormone	hormone	NOUN
bibechana-21109	224	23	:	:	PUNCT
bibechana-21109	224	24	perspective	perspective	NOUN
bibechana-21109	224	25	and	and	CCONJ
bibechana-21109	224	26	prognosis	prognosis	NOUN
bibechana-21109	224	27	,	,	PUNCT
bibechana-21109	224	28	j.	j.	PROPN
bibechana-21109	224	29	thyroid	thyroid	PROPN
bibechana-21109	224	30	research	research	NOUN
bibechana-21109	224	31	,	,	PUNCT
bibechana-21109	224	32	2011	2011	NUM
bibechana-21109	224	33	(	(	PUNCT
bibechana-21109	224	34	2011	2011	NUM
bibechana-21109	224	35	)	)	PUNCT
bibechana-21109	224	36	20.doi.org/10.4061/2011/361304	20.doi.org/10.4061/2011/361304	NUM
bibechana-21109	224	37	.	.	PUNCT
bibechana-21109	225	1	[	[	X
bibechana-21109	225	2	14	14	NUM
bibechana-21109	225	3	]	]	PUNCT
bibechana-21109	225	4	m.	m.	PROPN
bibechana-21109	225	5	d.	d.	PROPN
bibechana-21109	225	6	rosen	rosen	PROPN
bibechana-21109	225	7	,	,	PUNCT
bibechana-21109	225	8	m.	m.	PROPN
bibechana-21109	225	9	l.	l.	PROPN
bibechana-21109	225	10	privalsky	privalsky	PROPN
bibechana-21109	225	11	,	,	PUNCT
bibechana-21109	225	12	thyroid	thyroid	VERB
bibechana-21109	225	13	hormone	hormone	NOUN
bibechana-21109	225	14	receptor	receptor	NOUN
bibechana-21109	225	15	mutations	mutation	NOUN
bibechana-21109	225	16	found	find	VERB
bibechana-21109	225	17	in	in	ADP
bibechana-21109	225	18	renal	renal	ADJ
bibechana-21109	225	19	clear	clear	ADJ
bibechana-21109	225	20	cell	cell	NOUN
bibechana-21109	225	21	carcinomas	carcinoma	NOUN
bibechana-21109	225	22	alter	alter	VERB
bibechana-21109	225	23	corepressor	corepressor	NOUN
bibechana-21109	225	24	release	release	NOUN
bibechana-21109	225	25	and	and	CCONJ
bibechana-21109	225	26	reveal	reveal	VERB
bibechana-21109	225	27	helix	helix	NOUN
bibechana-21109	225	28	12	12	NUM
bibechana-21109	225	29	as	as	ADP
bibechana-21109	225	30	key	key	ADJ
bibechana-21109	225	31	determinant	determinant	ADJ
bibechana-21109	225	32	of	of	ADP
bibechana-21109	225	33	corepressor	corepressor	NOUN
bibechana-21109	225	34	specificity	specificity	NOUN
bibechana-21109	225	35	,	,	PUNCT
bibechana-21109	225	36	mol	mol	PROPN
bibechana-21109	225	37	.	.	PROPN
bibechana-21109	225	38	endocrinol	endocrinol	NOUN
bibechana-21109	225	39	.	.	PUNCT
bibechana-21109	226	1	23	23	NUM
bibechana-21109	226	2	(	(	PUNCT
bibechana-21109	226	3	2009	2009	NUM
bibechana-21109	226	4	)	)	PUNCT
bibechana-21109	226	5	1183	1183	NUM
bibechana-21109	226	6	-	-	SYM
bibechana-21109	226	7	1192	1192	NUM
bibechana-21109	226	8	.	.	PUNCT
bibechana-21109	227	1	doi.org/10.1210/me.2009-0126	doi.org/10.1210/me.2009-0126	NOUN
bibechana-21109	227	2	.	.	PUNCT
bibechana-21109	228	1	[	[	X
bibechana-21109	228	2	15	15	NUM
bibechana-21109	228	3	]	]	X
bibechana-21109	228	4	a.s	a.s	PROPN
bibechana-21109	228	5	.	.	PROPN
bibechana-21109	228	6	nascimento	nascimento	PROPN
bibechana-21109	228	7	,	,	PUNCT
bibechana-21109	228	8	s.	s.	PROPN
bibechana-21109	228	9	m.	m.	PROPN
bibechana-21109	228	10	g.	g.	PROPN
bibechana-21109	228	11	dias	dias	PROPN
bibechana-21109	228	12	,	,	PUNCT
bibechana-21109	228	13	f.	f.	PROPN
bibechana-21109	228	14	m.	m.	PROPN
bibechana-21109	228	15	nunes	nunes	PROPN
bibechana-21109	228	16	,	,	PUNCT
bibechana-21109	228	17	r.	r.	PROPN
bibechana-21109	228	18	aparício	aparício	PROPN
bibechana-21109	228	19	,	,	PUNCT
bibechana-21109	228	20	a.	a.	PROPN
bibechana-21109	228	21	l.	l.	PROPN
bibechana-21109	228	22	ambrosio	ambrosio	PROPN
bibechana-21109	228	23	,	,	PUNCT
bibechana-21109	228	24	bleicher	bleicher	PROPN
bibechana-21109	228	25	,	,	PUNCT
bibechana-21109	228	26	l.	l.	PROPN
bibechana-21109	228	27	,	,	PUNCT
bibechana-21109	228	28	a.	a.	PROPN
bibechana-21109	228	29	c.	c.	PROPN
bibechana-21109	228	30	m.	m.	PROPN
bibechana-21109	228	31	figueira	figueira	PROPN
bibechana-21109	228	32	,	,	PUNCT
bibechana-21109	228	33	m.	m.	NOUN
bibechana-21109	228	34	a.	a.	PROPN
bibechana-21109	228	35	m.	m.	PROPN
bibechana-21109	228	36	santos	santos	PROPN
bibechana-21109	228	37	,	,	PUNCT
bibechana-21109	228	38	m.	m.	PROPN
bibechana-21109	228	39	de	de	PROPN
bibechana-21109	228	40	oliveira	oliveira	PROPN
bibechana-21109	228	41	neto	neto	PROPN
bibechana-21109	228	42	,	,	PUNCT
bibechana-21109	228	43	h.	h.	PROPN
bibechana-21109	228	44	fischer	fischer	PROPN
bibechana-21109	228	45	,	,	PUNCT
bibechana-21109	228	46	m.	m.	NOUN
bibechana-21109	228	47	togashi	togashi	PROPN
bibechana-21109	228	48	,	,	PUNCT
bibechana-21109	228	49	structural	structural	ADJ
bibechana-21109	228	50	rearrangements	rearrangement	NOUN
bibechana-21109	228	51	in	in	ADP
bibechana-21109	228	52	the	the	DET
bibechana-21109	228	53	thyroid	thyroid	NOUN
bibechana-21109	228	54	hormone	hormone	NOUN
bibechana-21109	228	55	receptor	receptor	NOUN
bibechana-21109	228	56	hinge	hinge	NOUN
bibechana-21109	228	57	domain	domain	NOUN
bibechana-21109	228	58	and	and	CCONJ
bibechana-21109	228	59	their	their	PRON
bibechana-21109	228	60	putative	putative	ADJ
bibechana-21109	228	61	role	role	NOUN
bibechana-21109	228	62	in	in	ADP
bibechana-21109	228	63	the	the	DET
bibechana-21109	228	64	receptor	receptor	NOUN
bibechana-21109	228	65	function	function	NOUN
bibechana-21109	228	66	,	,	PUNCT
bibechana-21109	228	67	j.	j.	PROPN
bibechana-21109	228	68	mol	mol	PROPN
bibechana-21109	228	69	.	.	PUNCT
bibechana-21109	229	1	biol	biol	PROPN
bibechana-21109	229	2	.	.	PUNCT
bibechana-21109	230	1	360	360	NUM
bibechana-21109	230	2	(	(	PUNCT
bibechana-21109	230	3	2006	2006	NUM
bibechana-21109	230	4	)	)	PUNCT
bibechana-21109	230	5	586-598.doi.org/10.1016/j.jmb.2006.05.008	586-598.doi.org/10.1016/j.jmb.2006.05.008	NOUN
bibechana-21109	230	6	.	.	PUNCT
bibechana-21109	231	1	[	[	X
bibechana-21109	231	2	16	16	NUM
bibechana-21109	231	3	]	]	PUNCT
bibechana-21109	231	4	a.	a.	PROPN
bibechana-21109	231	5	d.	d.	PROPN
bibechana-21109	231	6	mackerell	mackerell	PROPN
bibechana-21109	231	7	,	,	PUNCT
bibechana-21109	231	8	m.	m.	NOUN
bibechana-21109	231	9	feig	feig	PROPN
bibechana-21109	231	10	,	,	PUNCT
bibechana-21109	231	11	c.	c.	PROPN
bibechana-21109	231	12	l.	l.	PROPN
bibechana-21109	231	13	brooks	brooks	PROPN
bibechana-21109	231	14	,	,	PUNCT
bibechana-21109	231	15	extending	extend	VERB
bibechana-21109	231	16	the	the	DET
bibechana-21109	231	17	treatment	treatment	NOUN
bibechana-21109	231	18	of	of	ADP
bibechana-21109	231	19	backbone	backbone	NOUN
bibechana-21109	231	20	energetics	energetic	NOUN
bibechana-21109	231	21	in	in	ADP
bibechana-21109	231	22	protein	protein	NOUN
bibechana-21109	231	23	force	force	NOUN
bibechana-21109	231	24	fields	field	NOUN
bibechana-21109	231	25	:	:	PUNCT
bibechana-21109	231	26	limitations	limitation	NOUN
bibechana-21109	231	27	of	of	ADP
bibechana-21109	231	28	gas‐phase	gas‐phase	VERB
bibechana-21109	231	29	quantum	quantum	ADJ
bibechana-21109	231	30	mechanics	mechanic	NOUN
bibechana-21109	231	31	in	in	ADP
bibechana-21109	231	32	reproducing	reproduce	VERB
bibechana-21109	231	33	protein	protein	NOUN
bibechana-21109	231	34	conformational	conformational	ADJ
bibechana-21109	231	35	distributions	distribution	NOUN
bibechana-21109	231	36	in	in	ADP
bibechana-21109	231	37	molecular	molecular	ADJ
bibechana-21109	231	38	dynamics	dynamic	NOUN
bibechana-21109	231	39	simulations	simulation	NOUN
bibechana-21109	231	40	,	,	PUNCT
bibechana-21109	231	41	j.	j.	PROPN
bibechana-21109	231	42	comp	comp	PROPN
bibechana-21109	231	43	.	.	PUNCT
bibechana-21109	231	44	chem	chem	PROPN
bibechana-21109	231	45	.	.	PUNCT
bibechana-21109	232	1	25(2004	25(2004	NUM
bibechana-21109	232	2	)	)	PUNCT
bibechana-21109	232	3	1400	1400	NUM
bibechana-21109	232	4	-	-	SYM
bibechana-21109	232	5	1415	1415	NUM
bibechana-21109	232	6	.	.	PUNCT
bibechana-21109	233	1	doi.org/10.1002/jcc.20065	doi.org/10.1002/jcc.20065	NOUN
bibechana-21109	233	2	.	.	PUNCT
bibechana-21109	234	1	[	[	X
bibechana-21109	234	2	17	17	NUM
bibechana-21109	234	3	]	]	PUNCT
bibechana-21109	234	4	a.	a.	PROPN
bibechana-21109	234	5	d.	d.	PROPN
bibechana-21109	234	6	mackerell	mackerell	PROPN
bibechana-21109	234	7	,	,	PUNCT
bibechana-21109	234	8	d.	d.	PROPN
bibechana-21109	234	9	bashford	bashford	PROPN
bibechana-21109	234	10	,	,	PUNCT
bibechana-21109	234	11	m.	m.	NOUN
bibechana-21109	234	12	bellott	bellott	PROPN
bibechana-21109	234	13	,	,	PUNCT
bibechana-21109	234	14	r.	r.	PROPN
bibechana-21109	234	15	l.	l.	PROPN
bibechana-21109	234	16	dunbrack	dunbrack	PROPN
bibechana-21109	234	17	,	,	PUNCT
bibechana-21109	234	18	j.	j.	PROPN
bibechana-21109	234	19	d.	d.	PROPN
bibechana-21109	234	20	evanseck	evanseck	PROPN
bibechana-21109	234	21	,	,	PUNCT
bibechana-21109	234	22	m.	m.	NOUN
bibechana-21109	234	23	j.	j.	PROPN
bibechana-21109	234	24	field	field	PROPN
bibechana-21109	234	25	,	,	PUNCT
bibechana-21109	234	26	s.	s.	PROPN
bibechana-21109	234	27	fischer	fischer	PROPN
bibechana-21109	234	28	,	,	PUNCT
bibechana-21109	234	29	j.	j.	PROPN
bibechana-21109	234	30	gao	gao	PROPN
bibechana-21109	234	31	,	,	PUNCT
bibechana-21109	234	32	h.	h.	PROPN
bibechana-21109	234	33	guo	guo	PROPN
bibechana-21109	234	34	,	,	PUNCT
bibechana-21109	234	35	s.	s.	PROPN
bibechana-21109	234	36	ha	ha	PROPN
bibechana-21109	234	37	,	,	PUNCT
bibechana-21109	234	38	d.	d.	PROPN
bibechana-21109	234	39	joseph	joseph	PROPN
bibechana-21109	234	40	-	-	PUNCT
bibechana-21109	234	41	mccarthy	mccarthy	PROPN
bibechana-21109	234	42	,	,	PUNCT
bibechana-21109	234	43	all	all	DET
bibechana-21109	234	44	-	-	PUNCT
bibechana-21109	234	45	atom	atom	NOUN
bibechana-21109	234	46	empirical	empirical	ADJ
bibechana-21109	234	47	potential	potential	NOUN
bibechana-21109	234	48	for	for	ADP
bibechana-21109	234	49	molecular	molecular	ADJ
bibechana-21109	234	50	modeling	modeling	NOUN
bibechana-21109	234	51	and	and	CCONJ
bibechana-21109	234	52	dynamics	dynamic	NOUN
bibechana-21109	234	53	studies	study	NOUN
bibechana-21109	234	54	of	of	ADP
bibechana-21109	234	55	proteins	protein	NOUN
bibechana-21109	234	56	,	,	PUNCT
bibechana-21109	234	57	j.	j.	PROPN
bibechana-21109	234	58	phys	phys	PROPN
bibechana-21109	234	59	.	.	PUNCT
bibechana-21109	235	1	chem	chem	PROPN
bibechana-21109	235	2	.	.	PUNCT
bibechana-21109	236	1	b	b	X
bibechana-21109	236	2	102	102	NUM
bibechana-21109	236	3	(	(	PUNCT
bibechana-21109	236	4	1998	1998	NUM
bibechana-21109	236	5	)	)	PUNCT
bibechana-21109	236	6	3586–3616	3586–3616	NUM
bibechana-21109	236	7	.	.	PUNCT
bibechana-21109	237	1	doi.org/10.1021/jp973084f	doi.org/10.1021/jp973084f	NOUN
bibechana-21109	237	2	.	.	PUNCT
bibechana-21109	238	1	[	[	X
bibechana-21109	238	2	18	18	NUM
bibechana-21109	238	3	]	]	X
bibechana-21109	238	4	w.	w.	PROPN
bibechana-21109	238	5	l.	l.	PROPN
bibechana-21109	238	6	jorgensen	jorgensen	PROPN
bibechana-21109	238	7	,	,	PUNCT
bibechana-21109	238	8	j.	j.	PROPN
bibechana-21109	238	9	chandrasekhar	chandrasekhar	PROPN
bibechana-21109	238	10	,	,	PUNCT
bibechana-21109	238	11	j.	j.	PROPN
bibechana-21109	238	12	d.	d.	PROPN
bibechana-21109	238	13	madura	madura	PROPN
bibechana-21109	238	14	,	,	PUNCT
bibechana-21109	238	15	r.	r.	PROPN
bibechana-21109	238	16	w.	w.	PROPN
bibechana-21109	238	17	impey	impey	PROPN
bibechana-21109	238	18	,	,	PUNCT
bibechana-21109	238	19	m.	m.	PROPN
bibechana-21109	238	20	l.	l.	PROPN
bibechana-21109	238	21	klein	klein	PROPN
bibechana-21109	238	22	,	,	PUNCT
bibechana-21109	238	23	comparison	comparison	NOUN
bibechana-21109	238	24	of	of	ADP
bibechana-21109	238	25	simple	simple	ADJ
bibechana-21109	238	26	potential	potential	ADJ
bibechana-21109	238	27	functions	function	NOUN
bibechana-21109	238	28	for	for	ADP
bibechana-21109	238	29	simulating	simulate	VERB
bibechana-21109	238	30	liquid	liquid	ADJ
bibechana-21109	238	31	water	water	NOUN
bibechana-21109	238	32	,	,	PUNCT
bibechana-21109	238	33	j.	j.	PROPN
bibechana-21109	238	34	chem	chem	PROPN
bibechana-21109	238	35	.	.	PUNCT
bibechana-21109	239	1	phys	phy	NOUN
bibechana-21109	239	2	.	.	PUNCT
bibechana-21109	240	1	79	79	NUM
bibechana-21109	240	2	(	(	PUNCT
bibechana-21109	240	3	1983	1983	NUM
bibechana-21109	240	4	)	)	PUNCT
bibechana-21109	241	1	926–935	926–935	NUM
bibechana-21109	241	2	.	.	PUNCT
bibechana-21109	242	1	doi.org/10.1063/1.445869	doi.org/10.1063/1.445869	NOUN
bibechana-21109	242	2	.	.	PUNCT
bibechana-21109	243	1	[	[	X
bibechana-21109	243	2	19	19	NUM
bibechana-21109	243	3	]	]	X
bibechana-21109	243	4	v.	v.	PROPN
bibechana-21109	243	5	zoete	zoete	PROPN
bibechana-21109	243	6	,	,	PUNCT
bibechana-21109	243	7	m.	m.	NOUN
bibechana-21109	243	8	a.	a.	NOUN
bibechana-21109	243	9	cuendet	cuendet	PROPN
bibechana-21109	243	10	,	,	PUNCT
bibechana-21109	243	11	a.	a.	NOUN
bibechana-21109	243	12	grosdidier	grosdidier	NOUN
bibechana-21109	243	13	,	,	PUNCT
bibechana-21109	243	14	o.	o.	PROPN
bibechana-21109	243	15	michielin	michielin	PROPN
bibechana-21109	243	16	,	,	PUNCT
bibechana-21109	243	17	swissparam	swissparam	PROPN
bibechana-21109	243	18	:	:	PUNCT
bibechana-21109	243	19	a	a	DET
bibechana-21109	243	20	fast	fast	ADJ
bibechana-21109	243	21	force	force	NOUN
bibechana-21109	243	22	field	field	NOUN
bibechana-21109	243	23	generation	generation	NOUN
bibechana-21109	243	24	tool	tool	NOUN
bibechana-21109	243	25	for	for	ADP
bibechana-21109	243	26	small	small	ADJ
bibechana-21109	243	27	organic	organic	ADJ
bibechana-21109	243	28	molecules	molecule	NOUN
bibechana-21109	243	29	,	,	PUNCT
bibechana-21109	243	30	j.	j.	PROPN
bibechana-21109	243	31	comp	comp	PROPN
bibechana-21109	243	32	.	.	PUNCT
bibechana-21109	243	33	chem.32(2011	chem.32(2011	NOUN
bibechana-21109	243	34	)	)	PUNCT
bibechana-21109	243	35	2359	2359	NUM
bibechana-21109	243	36	-	-	SYM
bibechana-21109	243	37	2368	2368	NUM
bibechana-21109	243	38	.	.	PUNCT
bibechana-21109	244	1	doi.org/	doi.org/	ADP
bibechana-21109	244	2	10.1002	10.1002	NUM
bibechana-21109	244	3	/	/	SYM
bibechana-21109	244	4	jcc.21816	jcc.21816	X
bibechana-21109	244	5	.	.	PUNCT
bibechana-21109	245	1	[	[	X
bibechana-21109	245	2	20	20	NUM
bibechana-21109	245	3	]	]	PUNCT
bibechana-21109	245	4	w.	w.	PROPN
bibechana-21109	245	5	humphrey	humphrey	PROPN
bibechana-21109	245	6	,	,	PUNCT
bibechana-21109	245	7	a.	a.	PROPN
bibechana-21109	245	8	dalke	dalke	PROPN
bibechana-21109	245	9	,	,	PUNCT
bibechana-21109	245	10	k.	k.	PROPN
bibechana-21109	245	11	schulten	schulten	PROPN
bibechana-21109	245	12	,	,	PUNCT
bibechana-21109	245	13	vmd	vmd	PROPN
bibechana-21109	245	14	—	—	PUNCT
bibechana-21109	245	15	visual	visual	ADJ
bibechana-21109	245	16	molecular	molecular	ADJ
bibechana-21109	245	17	dynamics	dynamic	NOUN
bibechana-21109	245	18	,	,	PUNCT
bibechana-21109	245	19	j.	j.	PROPN
bibechana-21109	245	20	mol	mol	PROPN
bibechana-21109	245	21	.	.	PUNCT
bibechana-21109	245	22	graphics	graphic	NOUN
bibechana-21109	245	23	14	14	NUM
bibechana-21109	245	24	(	(	PUNCT
bibechana-21109	245	25	1996	1996	NUM
bibechana-21109	245	26	)	)	PUNCT
bibechana-21109	245	27	33–38	33–38	NUM
bibechana-21109	245	28	.	.	PUNCT
bibechana-21109	246	1	doi.org/10.1016/0263-7855(96)00018-5	doi.org/10.1016/0263-7855(96)00018-5	PROPN
bibechana-21109	246	2	.	.	PUNCT
bibechana-21109	247	1	[	[	X
bibechana-21109	247	2	21	21	NUM
bibechana-21109	247	3	]	]	X
bibechana-21109	247	4	j.	j.	PROPN
bibechana-21109	247	5	c.	c.	PROPN
bibechana-21109	247	6	phillips	phillips	PROPN
bibechana-21109	247	7	,	,	PUNCT
bibechana-21109	247	8	r.	r.	PROPN
bibechana-21109	247	9	braun	braun	PROPN
bibechana-21109	247	10	,	,	PUNCT
bibechana-21109	247	11	w.	w.	PROPN
bibechana-21109	247	12	wang	wang	PROPN
bibechana-21109	247	13	,	,	PUNCT
bibechana-21109	247	14	j.	j.	PROPN
bibechana-21109	247	15	gumbart	gumbart	PROPN
bibechana-21109	247	16	,	,	PUNCT
bibechana-21109	247	17	e.	e.	PROPN
bibechana-21109	247	18	takhorshid	takhorshid	PROPN
bibechana-21109	247	19	,	,	PUNCT
bibechana-21109	247	20	e.	e.	PROPN
bibechana-21109	247	21	villa	villa	PROPN
bibechana-21109	247	22	,	,	PUNCT
bibechana-21109	247	23	c.	c.	PROPN
bibechana-21109	247	24	chipot	chipot	PROPN
bibechana-21109	247	25	,	,	PUNCT
bibechana-21109	247	26	r.	r.	PROPN
bibechana-21109	247	27	d.	d.	PROPN
bibechana-21109	247	28	skeel	skeel	PROPN
bibechana-21109	247	29	,	,	PUNCT
bibechana-21109	247	30	l.	l.	PROPN
bibechana-21109	247	31	kale	kale	PROPN
bibechana-21109	247	32	,	,	PUNCT
bibechana-21109	247	33	k.	k.	PROPN
bibechana-21109	247	34	schulten	schulten	PROPN
bibechana-21109	247	35	,	,	PUNCT
bibechana-21109	247	36	scalable	scalable	ADJ
bibechana-21109	247	37	molecular	molecular	ADJ
bibechana-21109	247	38	dynamics	dynamic	NOUN
bibechana-21109	247	39	with	with	ADP
bibechana-21109	247	40	namd	namd	NOUN
bibechana-21109	247	41	,	,	PUNCT
bibechana-21109	247	42	j.	j.	PROPN
bibechana-21109	247	43	comput	comput	PROPN
bibechana-21109	247	44	.	.	PUNCT
bibechana-21109	248	1	chem	chem	NOUN
bibechana-21109	248	2	.	.	PUNCT
bibechana-21109	249	1	26	26	NUM
bibechana-21109	249	2	(	(	PUNCT
bibechana-21109	249	3	2005	2005	NUM
bibechana-21109	249	4	)	)	PUNCT
bibechana-21109	249	5	1781–1802	1781–1802	NUM
bibechana-21109	249	6	.	.	PUNCT
bibechana-21109	250	1	doi.org/	doi.org/	ADP
bibechana-21109	250	2	10.1002	10.1002	NUM
bibechana-21109	250	3	/	/	SYM
bibechana-21109	250	4	jcc.20289	jcc.20289	NOUN
bibechana-21109	250	5	.	.	PUNCT
bibechana-21109	251	1	[	[	X
bibechana-21109	251	2	22	22	NUM
bibechana-21109	251	3	]	]	PUNCT
bibechana-21109	251	4	s.	s.	PROPN
bibechana-21109	251	5	e.	e.	PROPN
bibechana-21109	251	6	feller	feller	PROPN
bibechana-21109	251	7	,	,	PUNCT
bibechana-21109	251	8	y.	y.	PROPN
bibechana-21109	251	9	zhang	zhang	PROPN
bibechana-21109	251	10	,	,	PUNCT
bibechana-21109	251	11	r.	r.	PROPN
bibechana-21109	251	12	w.	w.	PROPN
bibechana-21109	251	13	pastor	pastor	PROPN
bibechana-21109	251	14	,	,	PUNCT
bibechana-21109	251	15	b.	b.	PROPN
bibechana-21109	251	16	r.	r.	PROPN
bibechana-21109	251	17	brooks	brooks	PROPN
bibechana-21109	251	18	,	,	PUNCT
bibechana-21109	251	19	constant	constant	ADJ
bibechana-21109	251	20	pressure	pressure	NOUN
bibechana-21109	251	21	molecular	molecular	ADJ
bibechana-21109	251	22	dynamics	dynamic	NOUN
bibechana-21109	251	23	simulation	simulation	NOUN
bibechana-21109	251	24	:	:	PUNCT
bibechana-21109	251	25	the	the	DET
bibechana-21109	251	26	langevin	langevin	PROPN
bibechana-21109	251	27	piston	piston	PROPN
bibechana-21109	251	28	method	method	NOUN
bibechana-21109	251	29	,	,	PUNCT
bibechana-21109	251	30	j.	j.	PROPN
bibechana-21109	251	31	chem	chem	PROPN
bibechana-21109	251	32	.	.	PUNCT
bibechana-21109	252	1	phys	phy	NOUN
bibechana-21109	252	2	.	.	PUNCT
bibechana-21109	253	1	103	103	NUM
bibechana-21109	253	2	(	(	PUNCT
bibechana-21109	253	3	1995	1995	NUM
bibechana-21109	253	4	)	)	PUNCT
bibechana-21109	253	5	4613-4621.doi.org/10.1063/1.470648	4613-4621.doi.org/10.1063/1.470648	NOUN
bibechana-21109	253	6	.	.	PUNCT
bibechana-21109	254	1	[	[	X
bibechana-21109	254	2	23	23	NUM
bibechana-21109	254	3	]	]	X
bibechana-21109	254	4	g.	g.	PROPN
bibechana-21109	254	5	bussi	bussi	PROPN
bibechana-21109	254	6	,	,	PUNCT
bibechana-21109	254	7	d.	d.	PROPN
bibechana-21109	254	8	donadio	donadio	PROPN
bibechana-21109	254	9	,	,	PUNCT
bibechana-21109	254	10	m.	m.	NOUN
bibechana-21109	254	11	parrinello	parrinello	PROPN
bibechana-21109	254	12	,	,	PUNCT
bibechana-21109	254	13	canonical	canonical	ADJ
bibechana-21109	254	14	sampling	sample	VERB
bibechana-21109	254	15	through	through	ADP
bibechana-21109	254	16	velocity	velocity	NOUN
bibechana-21109	254	17	rescaling	rescaling	NOUN
bibechana-21109	254	18	,	,	PUNCT
bibechana-21109	254	19	j.	j.	PROPN
bibechana-21109	254	20	chem	chem	PROPN
bibechana-21109	254	21	phys	phys	PROPN
bibechana-21109	254	22	.	.	PUNCT
bibechana-21109	255	1	126(2007	126(2007	NUM
bibechana-21109	255	2	)	)	PUNCT
bibechana-21109	255	3	014101.doi.org/10.1063/1.2408420	014101.doi.org/10.1063/1.2408420	NUM
bibechana-21109	255	4	.	.	PUNCT
bibechana-21109	256	1	[	[	X
bibechana-21109	256	2	24	24	NUM
bibechana-21109	256	3	]	]	PUNCT
bibechana-21109	256	4	t.	t.	PROPN
bibechana-21109	256	5	darden	darden	PROPN
bibechana-21109	256	6	,	,	PUNCT
bibechana-21109	256	7	d.	d.	PROPN
bibechana-21109	256	8	york	york	PROPN
bibechana-21109	256	9	,	,	PUNCT
bibechana-21109	256	10	l.	l.	PROPN
bibechana-21109	256	11	pedersen	pedersen	PROPN
bibechana-21109	256	12	,	,	PUNCT
bibechana-21109	256	13	particle	particle	NOUN
bibechana-21109	256	14	mesh	mesh	PROPN
bibechana-21109	256	15	ewald	ewald	PROPN
bibechana-21109	256	16	:	:	PUNCT
bibechana-21109	256	17	an	an	DET
bibechana-21109	256	18	n·log(n	n·log(n	NOUN
bibechana-21109	256	19	)	)	PUNCT
bibechana-21109	256	20	method	method	NOUN
bibechana-21109	256	21	for	for	ADP
bibechana-21109	256	22	ewald	ewald	PROPN
bibechana-21109	256	23	sums	sum	NOUN
bibechana-21109	256	24	in	in	ADP
bibechana-21109	256	25	large	large	ADJ
bibechana-21109	256	26	systems	system	NOUN
bibechana-21109	256	27	,	,	PUNCT
bibechana-21109	256	28	j.	j.	PROPN
bibechana-21109	256	29	chem	chem	PROPN
bibechana-21109	256	30	.	.	PUNCT
bibechana-21109	257	1	phys	phy	NOUN
bibechana-21109	257	2	.	.	PUNCT
bibechana-21109	258	1	98	98	NUM
bibechana-21109	258	2	(	(	PUNCT
bibechana-21109	258	3	1993	1993	NUM
bibechana-21109	258	4	)	)	PUNCT
bibechana-21109	258	5	10089–10092	10089–10092	NUM
bibechana-21109	258	6	.	.	PUNCT
bibechana-21109	259	1	doi.org/10.1063/1.464397	doi.org/10.1063/1.464397	NOUN
bibechana-21109	259	2	.	.	PUNCT
bibechana-21109	260	1	[	[	X
bibechana-21109	260	2	25	25	NUM
bibechana-21109	260	3	]	]	PUNCT
bibechana-21109	260	4	l.	l.	PROPN
bibechana-21109	260	5	verlet	verlet	PROPN
bibechana-21109	260	6	,	,	PUNCT
bibechana-21109	260	7	computer	computer	NOUN
bibechana-21109	260	8	"	"	PUNCT
bibechana-21109	260	9	experiments	experiment	NOUN
bibechana-21109	260	10	"	"	PUNCT
bibechana-21109	260	11	on	on	ADP
bibechana-21109	260	12	classical	classical	ADJ
bibechana-21109	260	13	fluids	fluid	NOUN
bibechana-21109	260	14	.	.	PUNCT
bibechana-21109	261	1	i.	i.	PROPN
bibechana-21109	261	2	thermodynamical	thermodynamical	PROPN
bibechana-21109	261	3	properties	property	NOUN
bibechana-21109	261	4	of	of	ADP
bibechana-21109	261	5	lennard	lennard	PROPN
bibechana-21109	261	6	-	-	PUNCT
bibechana-21109	261	7	jones	jones	PROPN
bibechana-21109	261	8	molecules	molecules	PROPN
bibechana-21109	261	9	,	,	PUNCT
bibechana-21109	261	10	phy	phy	PROPN
bibechana-21109	261	11	.	.	PUNCT
bibechana-21109	261	12	rev	rev	PROPN
bibechana-21109	261	13	.	.	PROPN
bibechana-21109	261	14	159	159	NUM
bibechana-21109	261	15	(	(	PUNCT
bibechana-21109	261	16	1967	1967	NUM
bibechana-21109	261	17	)	)	PUNCT
bibechana-21109	261	18	98.doi.org/10.1103/physrev.159.98	98.doi.org/10.1103/physrev.159.98	NUM
bibechana-21109	261	19	.	.	PUNCT
bibechana-21109	262	1	[	[	X
bibechana-21109	262	2	26	26	NUM
bibechana-21109	262	3	]	]	PUNCT
bibechana-21109	262	4	s.	s.	PROPN
bibechana-21109	262	5	a.	a.	PROPN
bibechana-21109	262	6	hollingsworth	hollingsworth	PROPN
bibechana-21109	262	7	,	,	PUNCT
bibechana-21109	262	8	p.	p.	NOUN
bibechana-21109	262	9	a.	a.	PROPN
bibechana-21109	262	10	karplus	karplus	PROPN
bibechana-21109	262	11	,	,	PUNCT
bibechana-21109	262	12	a	a	DET
bibechana-21109	262	13	fresh	fresh	ADJ
bibechana-21109	262	14	look	look	NOUN
bibechana-21109	262	15	at	at	ADP
bibechana-21109	262	16	the	the	DET
bibechana-21109	262	17	ramachandran	ramachandran	PROPN
bibechana-21109	262	18	plot	plot	NOUN
bibechana-21109	262	19	and	and	CCONJ
bibechana-21109	262	20	the	the	DET
bibechana-21109	262	21	occurrence	occurrence	NOUN
bibechana-21109	262	22	of	of	ADP
bibechana-21109	262	23	standard	standard	ADJ
bibechana-21109	262	24	structures	structure	NOUN
bibechana-21109	262	25	in	in	ADP
bibechana-21109	262	26	proteins	protein	NOUN
bibechana-21109	262	27	,	,	PUNCT
bibechana-21109	262	28	biomol	biomol	PROPN
bibechana-21109	262	29	.	.	PUNCT
bibechana-21109	263	1	concepts	concept	VERB
bibechana-21109	263	2	1(2010	1(2010	NUM
bibechana-21109	263	3	)	)	PUNCT
bibechana-21109	263	4	271	271	NUM
bibechana-21109	263	5	-	-	SYM
bibechana-21109	263	6	283	283	NUM
bibechana-21109	263	7	.	.	PUNCT
bibechana-21109	264	1	doi.org/10.1515/bmc.2010.022	doi.org/10.1515/bmc.2010.022	NOUN
bibechana-21109	264	2	.	.	PUNCT
bibechana-21109	265	1	[	[	X
bibechana-21109	265	2	27	27	NUM
bibechana-21109	265	3	]	]	X
bibechana-21109	265	4	b.	b.	PROPN
bibechana-21109	265	5	k.	k.	PROPN
bibechana-21109	265	6	ho	ho	PROPN
bibechana-21109	265	7	,	,	PUNCT
bibechana-21109	265	8	r.	r.	PROPN
bibechana-21109	265	9	brasseur	brasseur	PROPN
bibechana-21109	265	10	,	,	PUNCT
bibechana-21109	265	11	the	the	DET
bibechana-21109	265	12	ramachandran	ramachandran	NOUN
bibechana-21109	265	13	plots	plot	NOUN
bibechana-21109	265	14	of	of	ADP
bibechana-21109	265	15	glycine	glycine	NOUN
bibechana-21109	265	16	and	and	CCONJ
bibechana-21109	265	17	pre	pre	ADJ
bibechana-21109	265	18	-	-	ADJ
bibechana-21109	265	19	proline	proline	ADJ
bibechana-21109	265	20	,	,	PUNCT
bibechana-21109	265	21	bmc	bmc	NOUN
bibechana-21109	265	22	struct	struct	NOUN
bibechana-21109	265	23	.	.	PUNCT
bibechana-21109	266	1	biol	biol	PROPN
bibechana-21109	266	2	.	.	PUNCT
bibechana-21109	267	1	5	5	NUM
bibechana-21109	267	2	(	(	PUNCT
bibechana-21109	267	3	2005	2005	NUM
bibechana-21109	267	4	)	)	PUNCT
bibechana-21109	267	5	14.doi.org/10.1186/1472-6807-5-14	14.doi.org/10.1186/1472-6807-5-14	NUM
bibechana-21109	267	6	.	.	PUNCT
bibechana-21109	268	1	[	[	X
bibechana-21109	268	2	28	28	NUM
bibechana-21109	268	3	]	]	X
bibechana-21109	268	4	d.	d.	PROPN
bibechana-21109	268	5	gilis	gilis	PROPN
bibechana-21109	268	6	,	,	PUNCT
bibechana-21109	268	7	m.	m.	NOUN
bibechana-21109	268	8	rooman	rooman	NOUN
bibechana-21109	268	9	,	,	PUNCT
bibechana-21109	268	10	stability	stability	NOUN
bibechana-21109	268	11	changes	change	VERB
bibechana-21109	268	12	upon	upon	SCONJ
bibechana-21109	268	13	mutation	mutation	NOUN
bibechana-21109	268	14	of	of	ADP
bibechana-21109	268	15	solvent	solvent	NOUN
bibechana-21109	268	16	-	-	PUNCT
bibechana-21109	268	17	accessible	accessible	ADJ
bibechana-21109	268	18	residues	residue	NOUN
bibechana-21109	268	19	in	in	ADP
bibechana-21109	268	20	proteins	protein	NOUN
bibechana-21109	268	21	evaluated	evaluate	VERB
bibechana-21109	268	22	by	by	ADP
bibechana-21109	268	23	database	database	NOUN
bibechana-21109	268	24	-	-	PUNCT
bibechana-21109	268	25	derived	derive	VERB
bibechana-21109	268	26	potentials	potential	NOUN
bibechana-21109	268	27	,	,	PUNCT
bibechana-21109	268	28	j.	j.	PROPN
bibechana-21109	268	29	mol	mol	PROPN
bibechana-21109	268	30	.	.	PUNCT
bibechana-21109	269	1	biol	biol	PROPN
bibechana-21109	269	2	.	.	PUNCT
bibechana-21109	270	1	257(1996	257(1996	X
bibechana-21109	270	2	)	)	PUNCT
bibechana-21109	270	3	1112	1112	NUM
bibechana-21109	270	4	-	-	SYM
bibechana-21109	270	5	1126	1126	NUM
bibechana-21109	270	6	.	.	PUNCT
bibechana-21109	271	1	doi.org/10.1006/jmbi.1996.0226	doi.org/10.1006/jmbi.1996.0226	PROPN
bibechana-21109	271	2	.	.	PUNCT
bibechana-21109	272	1	tika	tika	PROPN
bibechana-21109	272	2	ram	ram	PROPN
bibechana-21109	272	3	lamichhane	lamichhane	PROPN
bibechana-21109	272	4	et	et	PROPN
bibechana-21109	272	5	al./	al./	ADV
bibechana-21109	272	6	bibechana	bibechana	PROPN
bibechana-21109	272	7	16	16	NUM
bibechana-21109	272	8	(	(	PUNCT
bibechana-21109	272	9	2019	2019	NUM
bibechana-21109	272	10	)	)	PUNCT
bibechana-21109	272	11	79	79	NUM
bibechana-21109	272	12	-	-	SYM
bibechana-21109	272	13	91	91	NUM
bibechana-21109	272	14	:	:	PUNCT
bibechana-21109	272	15	rcost	rcost	NOUN
bibechana-21109	272	16	p.91	p.91	X
bibechana-21109	272	17	(	(	PUNCT
bibechana-21109	272	18	online	online	ADJ
bibechana-21109	272	19	publication	publication	NOUN
bibechana-21109	272	20	:	:	PUNCT
bibechana-21109	272	21	dec	dec	PROPN
bibechana-21109	272	22	.	.	PROPN
bibechana-21109	272	23	,	,	PUNCT
bibechana-21109	272	24	2018	2018	NUM
bibechana-21109	272	25	)	)	PUNCT
bibechana-21109	273	1	[	[	X
bibechana-21109	273	2	29	29	NUM
bibechana-21109	273	3	]	]	PUNCT
bibechana-21109	273	4	m.	m.	NOUN
bibechana-21109	273	5	fernández	fernández	PROPN
bibechana-21109	273	6	,	,	PUNCT
bibechana-21109	273	7	j.	j.	PROPN
bibechana-21109	273	8	caballero	caballero	PROPN
bibechana-21109	273	9	,	,	PUNCT
bibechana-21109	273	10	l.	l.	PROPN
bibechana-21109	273	11	fernández	fernández	PROPN
bibechana-21109	273	12	,	,	PUNCT
bibechana-21109	273	13	j.	j.	PROPN
bibechana-21109	273	14	i.	i.	PROPN
bibechana-21109	273	15	abreu	abreu	PROPN
bibechana-21109	273	16	,	,	PUNCT
bibechana-21109	273	17	m.	m.	NOUN
bibechana-21109	273	18	garriga	garriga	PROPN
bibechana-21109	273	19	,	,	PUNCT
bibechana-21109	273	20	protein	protein	NOUN
bibechana-21109	273	21	radial	radial	ADJ
bibechana-21109	273	22	distribution	distribution	NOUN
bibechana-21109	273	23	function	function	NOUN
bibechana-21109	273	24	(	(	PUNCT
bibechana-21109	273	25	p	p	NOUN
bibechana-21109	273	26	-	-	PUNCT
bibechana-21109	273	27	rdf	rdf	VERB
bibechana-21109	273	28	)	)	PUNCT
bibechana-21109	273	29	and	and	CCONJ
bibechana-21109	273	30	bayesian	bayesian	NOUN
bibechana-21109	273	31	-	-	PUNCT
bibechana-21109	273	32	regularized	regularize	VERB
bibechana-21109	273	33	genetic	genetic	ADJ
bibechana-21109	273	34	neural	neural	ADJ
bibechana-21109	273	35	networks	network	NOUN
bibechana-21109	273	36	for	for	ADP
bibechana-21109	273	37	modeling	model	VERB
bibechana-21109	273	38	protein	protein	NOUN
bibechana-21109	273	39	conformational	conformational	ADJ
bibechana-21109	273	40	stability	stability	NOUN
bibechana-21109	273	41	:	:	PUNCT
bibechana-21109	273	42	chymotrypsin	chymotrypsin	VERB
bibechana-21109	273	43	inhibitor	inhibitor	NOUN
bibechana-21109	273	44	2	2	NUM
bibechana-21109	273	45	mutants	mutant	NOUN
bibechana-21109	273	46	,	,	PUNCT
bibechana-21109	273	47	j.	j.	PROPN
bibechana-21109	273	48	mol	mol	PROPN
bibechana-21109	273	49	.	.	PROPN
bibechana-21109	273	50	graph	graph	NOUN
bibechana-21109	273	51	.	.	PUNCT
bibechana-21109	274	1	modl	modl	NOUN
bibechana-21109	274	2	.	.	PUNCT
bibechana-21109	275	1	26(2007	26(2007	NUM
bibechana-21109	275	2	)	)	PUNCT
bibechana-21109	275	3	748	748	NUM
bibechana-21109	275	4	-	-	SYM
bibechana-21109	275	5	759	759	NUM
bibechana-21109	275	6	.	.	PUNCT
bibechana-21109	276	1	doi.org/10.1016/j.jmgm.2007.04.011	doi.org/10.1016/j.jmgm.2007.04.011	PROPN
bibechana-21109	276	2	.	.	PUNCT