id	sid	tid	token	lemma	pos
bibechana-25870	1	1	devendra	devendra	PROPN
bibechana-25870	1	2	sir	sir	PROPN
bibechana-25870	1	3	cover	cover	VERB
bibechana-25870	1	4	page	page	NOUN
bibechana-25870	1	5	copy.jpg	copy.jpg	X
bibechana-25870	1	6	bibechana	bibechana	NOUN
bibechana-25870	1	7	17	17	NUM
bibechana-25870	1	8	(	(	PUNCT
bibechana-25870	1	9	2020	2020	NUM
bibechana-25870	1	10	)	)	PUNCT
bibechana-25870	1	11	50	50	NUM
bibechana-25870	1	12	-	-	SYM
bibechana-25870	1	13	57	57	NUM
bibechana-25870	1	14	50	50	NUM
bibechana-25870	1	15	bibechana	bibechana	NOUN
bibechana-25870	1	16	issn	issn	VERB
bibechana-25870	1	17	2091	2091	NUM
bibechana-25870	1	18	-	-	SYM
bibechana-25870	1	19	0762	0762	NUM
bibechana-25870	1	20	(	(	PUNCT
bibechana-25870	1	21	print	print	NOUN
bibechana-25870	1	22	)	)	PUNCT
bibechana-25870	1	23	,	,	PUNCT
bibechana-25870	1	24	2382	2382	NUM
bibechana-25870	1	25	-	-	SYM
bibechana-25870	1	26	5340	5340	NUM
bibechana-25870	1	27	(	(	PUNCT
bibechana-25870	1	28	online	online	ADJ
bibechana-25870	1	29	)	)	PUNCT
bibechana-25870	1	30	journal	journal	NOUN
bibechana-25870	1	31	homepage	homepage	NOUN
bibechana-25870	1	32	:	:	PUNCT
bibechana-25870	1	33	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-25870	1	34	publisher	publisher	NOUN
bibechana-25870	1	35	:	:	PUNCT
bibechana-25870	1	36	department	department	NOUN
bibechana-25870	1	37	of	of	ADP
bibechana-25870	1	38	physics	physics	PROPN
bibechana-25870	1	39	,	,	PUNCT
bibechana-25870	1	40	mahendra	mahendra	PROPN
bibechana-25870	1	41	morang	morang	PROPN
bibechana-25870	1	42	a.m.	a.m.	PROPN
bibechana-25870	2	1	campus	campus	PROPN
bibechana-25870	2	2	,	,	PUNCT
bibechana-25870	2	3	tu	tu	PROPN
bibechana-25870	2	4	,	,	PUNCT
bibechana-25870	2	5	biratnagar	biratnagar	NOUN
bibechana-25870	2	6	,	,	PUNCT
bibechana-25870	2	7	nepal	nepal	ADJ
bibechana-25870	2	8	constant	constant	ADJ
bibechana-25870	2	9	velocity	velocity	NOUN
bibechana-25870	2	10	pulling	pull	VERB
bibechana-25870	2	11	and	and	CCONJ
bibechana-25870	2	12	unfolding	unfolding	NOUN
bibechana-25870	2	13	of	of	ADP
bibechana-25870	2	14	thyroid	thyroid	NOUN
bibechana-25870	2	15	hormone	hormone	NOUN
bibechana-25870	2	16	receptor	receptor	NOUN
bibechana-25870	2	17	by	by	ADP
bibechana-25870	2	18	steered	steer	VERB
bibechana-25870	2	19	molecular	molecular	ADJ
bibechana-25870	2	20	dynamics	dynamic	NOUN
bibechana-25870	2	21	tika	tika	X
bibechana-25870	2	22	ram	ram	PROPN
bibechana-25870	2	23	lamichhane	lamichhane	NOUN
bibechana-25870	2	24	,	,	PUNCT
bibechana-25870	2	25	hari	hari	PROPN
bibechana-25870	2	26	prasad	prasad	PROPN
bibechana-25870	2	27	lamichhane	lamichhane	PROPN
bibechana-25870	2	28	*	*	PROPN
bibechana-25870	2	29	central	central	PROPN
bibechana-25870	2	30	department	department	PROPN
bibechana-25870	2	31	of	of	ADP
bibechana-25870	2	32	physics	physics	PROPN
bibechana-25870	2	33	,	,	PUNCT
bibechana-25870	2	34	tribhuvan	tribhuvan	PROPN
bibechana-25870	2	35	university	university	PROPN
bibechana-25870	2	36	,	,	PUNCT
bibechana-25870	2	37	kirtipur	kirtipur	NOUN
bibechana-25870	2	38	,	,	PUNCT
bibechana-25870	2	39	kathmandu	kathmandu	NOUN
bibechana-25870	2	40	,	,	PUNCT
bibechana-25870	2	41	nepal	nepal	NOUN
bibechana-25870	2	42	*	*	NOUN
bibechana-25870	2	43	email	email	NOUN
bibechana-25870	2	44	:	:	PUNCT
bibechana-25870	2	45	tikaramlamichh@gmail.com	tikaramlamichh@gmail.com	X
bibechana-25870	2	46	article	article	NOUN
bibechana-25870	2	47	information	information	NOUN
bibechana-25870	2	48	:	:	PUNCT
bibechana-25870	2	49	received	receive	VERB
bibechana-25870	2	50	:	:	PUNCT
bibechana-25870	2	51	july	july	PROPN
bibechana-25870	2	52	06	06	NUM
bibechana-25870	2	53	,	,	PUNCT
bibechana-25870	2	54	2019	2019	NUM
bibechana-25870	2	55	accepted	accept	VERB
bibechana-25870	2	56	:	:	PUNCT
bibechana-25870	2	57	october	october	PROPN
bibechana-25870	2	58	7	7	NUM
bibechana-25870	2	59	,	,	PUNCT
bibechana-25870	2	60	2019	2019	NUM
bibechana-25870	2	61	keywords	keyword	NOUN
bibechana-25870	2	62	:	:	PUNCT
bibechana-25870	2	63	dynamicsmolecularsteered	dynamicsmolecularsteere	VERB
bibechana-25870	2	64	receptorhormonethyroid	receptorhormonethyroid	PROPN
bibechana-25870	2	65	triiodothyronine	triiodothyronine	ADJ
bibechana-25870	2	66	ligand	ligand	ADJ
bibechana-25870	2	67	binding	bind	VERB
bibechana-25870	2	68	domain	domain	NOUN
bibechana-25870	2	69	;	;	PUNCT
bibechana-25870	2	70	protein	protein	NOUN
bibechana-25870	2	71	unfolding	unfold	VERB
bibechana-25870	2	72	abstract	abstract	ADJ
bibechana-25870	2	73	unfolding	unfold	VERB
bibechana-25870	2	74	pathways	pathway	NOUN
bibechana-25870	2	75	of	of	ADP
bibechana-25870	2	76	t3	t3	PROPN
bibechana-25870	2	77	liganded	ligande	VERB
bibechana-25870	2	78	thyroid	thyroid	NOUN
bibechana-25870	2	79	hormone	hormone	NOUN
bibechana-25870	2	80	receptor	receptor	NOUN
bibechana-25870	2	81	(	(	PUNCT
bibechana-25870	2	82	thrt3	thrt3	NOUN
bibechana-25870	2	83	)	)	PUNCT
bibechana-25870	2	84	can	can	AUX
bibechana-25870	2	85	be	be	AUX
bibechana-25870	2	86	studied	study	VERB
bibechana-25870	2	87	by	by	ADP
bibechana-25870	2	88	using	use	VERB
bibechana-25870	2	89	the	the	DET
bibechana-25870	2	90	protocols	protocol	NOUN
bibechana-25870	2	91	of	of	ADP
bibechana-25870	2	92	steered	steered	ADJ
bibechana-25870	2	93	molecular	molecular	ADJ
bibechana-25870	2	94	dynamics	dynamic	NOUN
bibechana-25870	2	95	(	(	PUNCT
bibechana-25870	2	96	smd	smd	NOUN
bibechana-25870	2	97	)	)	PUNCT
bibechana-25870	2	98	.	.	PUNCT
bibechana-25870	3	1	theory	theory	NOUN
bibechana-25870	3	2	of	of	ADP
bibechana-25870	3	3	constant	constant	ADJ
bibechana-25870	3	4	velocity	velocity	NOUN
bibechana-25870	3	5	pulling	pull	VERB
bibechana-25870	3	6	has	have	AUX
bibechana-25870	3	7	been	be	AUX
bibechana-25870	3	8	implemented	implement	VERB
bibechana-25870	3	9	to	to	ADP
bibechana-25870	3	10	the	the	DET
bibechana-25870	3	11	structure	structure	NOUN
bibechana-25870	3	12	of	of	ADP
bibechana-25870	3	13	thrt3	thrt3	NOUN
bibechana-25870	3	14	in	in	ADP
bibechana-25870	3	15	a	a	DET
bibechana-25870	3	16	neutral	neutral	ADJ
bibechana-25870	3	17	water	water	NOUN
bibechana-25870	3	18	-	-	PUNCT
bibechana-25870	3	19	ion	ion	NOUN
bibechana-25870	3	20	solution	solution	NOUN
bibechana-25870	3	21	equilibrated	equilibrate	VERB
bibechana-25870	3	22	up	up	ADP
bibechana-25870	3	23	to	to	PART
bibechana-25870	3	24	20	20	NUM
bibechana-25870	3	25	ns	ns	NUM
bibechana-25870	3	26	.	.	PUNCT
bibechana-25870	4	1	the	the	DET
bibechana-25870	4	2	globular	globular	ADJ
bibechana-25870	4	3	form	form	NOUN
bibechana-25870	4	4	of	of	ADP
bibechana-25870	4	5	thrt3	thrt3	NOUN
bibechana-25870	4	6	is	be	AUX
bibechana-25870	4	7	completely	completely	ADV
bibechana-25870	4	8	unfolded	unfold	VERB
bibechana-25870	4	9	extending	extend	VERB
bibechana-25870	4	10	n	n	CCONJ
bibechana-25870	4	11	-	-	PUNCT
bibechana-25870	4	12	c	c	NOUN
bibechana-25870	4	13	termini	termini	NOUN
bibechana-25870	4	14	from	from	ADP
bibechana-25870	4	15	38	38	NUM
bibechana-25870	4	16	å	å	NOUN
bibechana-25870	4	17	to	to	ADP
bibechana-25870	4	18	876	876	NUM
bibechana-25870	4	19	å	å	PROPN
bibechana-25870	4	20	at	at	ADP
bibechana-25870	4	21	a	a	DET
bibechana-25870	4	22	constant	constant	ADJ
bibechana-25870	4	23	speed	speed	NOUN
bibechana-25870	4	24	of	of	ADP
bibechana-25870	4	25	0.1	0.1	NUM
bibechana-25870	4	26	å	å	NOUN
bibechana-25870	4	27	/	/	SYM
bibechana-25870	4	28	ps	ps	NOUN
bibechana-25870	4	29	by	by	ADP
bibechana-25870	4	30	means	mean	NOUN
bibechana-25870	4	31	of	of	ADP
bibechana-25870	4	32	8.5	8.5	NUM
bibechana-25870	4	33	ns	ns	NUM
bibechana-25870	4	34	long	long	ADJ
bibechana-25870	4	35	smd	smd	NOUN
bibechana-25870	4	36	simulations	simulation	NOUN
bibechana-25870	4	37	.	.	PUNCT
bibechana-25870	5	1	the	the	DET
bibechana-25870	5	2	peak	peak	NOUN
bibechana-25870	5	3	force	force	NOUN
bibechana-25870	5	4	measured	measure	VERB
bibechana-25870	5	5	in	in	ADP
bibechana-25870	5	6	the	the	DET
bibechana-25870	5	7	intermediate	intermediate	ADJ
bibechana-25870	5	8	conformations	conformation	NOUN
bibechana-25870	5	9	is	be	AUX
bibechana-25870	5	10	related	relate	VERB
bibechana-25870	5	11	to	to	ADP
bibechana-25870	5	12	a	a	DET
bibechana-25870	5	13	burst	burst	NOUN
bibechana-25870	5	14	of	of	ADP
bibechana-25870	5	15	backbone	backbone	NOUN
bibechana-25870	5	16	hbonds	hbond	NOUN
bibechana-25870	5	17	among	among	ADP
bibechana-25870	5	18	-helices	-helices	PROPN
bibechana-25870	5	19	and	and	CCONJ
bibechana-25870	5	20	-hairpins	-hairpins	PROPN
bibechana-25870	5	21	.	.	PUNCT
bibechana-25870	6	1	with	with	ADP
bibechana-25870	6	2	decrease	decrease	NOUN
bibechana-25870	6	3	in	in	ADP
bibechana-25870	6	4	h	h	NOUN
bibechana-25870	6	5	-	-	PUNCT
bibechana-25870	6	6	bonds	bond	NOUN
bibechana-25870	6	7	,	,	PUNCT
bibechana-25870	6	8	electrostatic	electrostatic	ADJ
bibechana-25870	6	9	energy	energy	NOUN
bibechana-25870	6	10	increases	increase	NOUN
bibechana-25870	6	11	by	by	ADP
bibechana-25870	6	12	losing	lose	VERB
bibechana-25870	6	13	gradually	gradually	ADV
bibechana-25870	6	14	the	the	DET
bibechana-25870	6	15	secondary	secondary	ADJ
bibechana-25870	6	16	structure	structure	NOUN
bibechana-25870	6	17	and	and	CCONJ
bibechana-25870	6	18	separating	separate	VERB
bibechana-25870	6	19			NOUN
bibechana-25870	6	20	and	and	CCONJ
bibechana-25870	6	21	-strands	-strands	PROPN
bibechana-25870	6	22	in	in	ADP
bibechana-25870	6	23	solution	solution	NOUN
bibechana-25870	6	24	.	.	PUNCT
bibechana-25870	7	1	the	the	DET
bibechana-25870	7	2	force	force	NOUN
bibechana-25870	7	3	at	at	ADP
bibechana-25870	7	4	the	the	DET
bibechana-25870	7	5	end	end	NOUN
bibechana-25870	7	6	(	(	PUNCT
bibechana-25870	7	7	t	t	X
bibechana-25870	7	8	>	>	X
bibechana-25870	7	9	8.5	8.5	NUM
bibechana-25870	7	10	ns	ns	NUM
bibechana-25870	7	11	)	)	PUNCT
bibechana-25870	7	12	increases	increase	VERB
bibechana-25870	7	13	steeply	steeply	ADV
bibechana-25870	7	14	with	with	ADP
bibechana-25870	7	15	the	the	DET
bibechana-25870	7	16	large	large	ADJ
bibechana-25870	7	17	increase	increase	NOUN
bibechana-25870	7	18	in	in	ADP
bibechana-25870	7	19	bond	bond	NOUN
bibechana-25870	7	20	-	-	PUNCT
bibechana-25870	7	21	angle	angle	NOUN
bibechana-25870	7	22	and	and	CCONJ
bibechana-25870	7	23	bond	bond	NOUN
bibechana-25870	7	24	-	-	PUNCT
bibechana-25870	7	25	length	length	NOUN
bibechana-25870	7	26	potentials	potential	VERB
bibechana-25870	7	27	when	when	SCONJ
bibechana-25870	7	28	the	the	DET
bibechana-25870	7	29	system	system	NOUN
bibechana-25870	7	30	becomes	becomes	AUX
bibechana-25870	7	31	completely	completely	ADV
bibechana-25870	7	32	unfolded	unfold	VERB
bibechana-25870	7	33	.	.	PUNCT
bibechana-25870	8	1	the	the	DET
bibechana-25870	8	2	hydrophobic	hydrophobic	NOUN
bibechana-25870	8	3	ligand	ligand	NOUN
bibechana-25870	8	4	binding	bind	VERB
bibechana-25870	8	5	domain	domain	NOUN
bibechana-25870	8	6	(	(	PUNCT
bibechana-25870	8	7	lbd	lbd	PROPN
bibechana-25870	8	8	)	)	PUNCT
bibechana-25870	8	9	of	of	ADP
bibechana-25870	8	10	thr-	thr-	VERB
bibechana-25870	8	11	with	with	ADP
bibechana-25870	8	12	load	load	NOUN
bibechana-25870	8	13	bearing	bear	VERB
bibechana-25870	8	14	h	h	NOUN
bibechana-25870	8	15	-	-	PUNCT
bibechana-25870	8	16	bonds	bond	NOUN
bibechana-25870	8	17	protects	protect	VERB
bibechana-25870	8	18	t3	t3	PROPN
bibechana-25870	8	19	from	from	ADP
bibechana-25870	8	20	water	water	NOUN
bibechana-25870	8	21	attack	attack	NOUN
bibechana-25870	8	22	.	.	PUNCT
bibechana-25870	9	1	even	even	ADV
bibechana-25870	9	2	after	after	ADP
bibechana-25870	9	3	complete	complete	ADJ
bibechana-25870	9	4	unfolding	unfolding	NOUN
bibechana-25870	9	5	of	of	ADP
bibechana-25870	9	6	thr-	thr-	PROPN
bibechana-25870	9	7	lbd	lbd	PROPN
bibechana-25870	9	8	,	,	PUNCT
bibechana-25870	9	9	the	the	DET
bibechana-25870	9	10	position	position	NOUN
bibechana-25870	9	11	of	of	ADP
bibechana-25870	9	12	t3	t3	PROPN
bibechana-25870	9	13	is	be	AUX
bibechana-25870	9	14	not	not	PART
bibechana-25870	9	15	deviated	deviate	VERB
bibechana-25870	9	16	more	more	ADJ
bibechana-25870	9	17	than	than	ADP
bibechana-25870	9	18	2.5	2.5	NUM
bibechana-25870	9	19	å	å	NOUN
bibechana-25870	9	20	and	and	CCONJ
bibechana-25870	9	21	a	a	DET
bibechana-25870	9	22	large	large	ADJ
bibechana-25870	9	23	number	number	NOUN
bibechana-25870	9	24	of	of	ADP
bibechana-25870	9	25	water	water	NOUN
bibechana-25870	9	26	molecules	molecule	NOUN
bibechana-25870	9	27	remain	remain	VERB
bibechana-25870	9	28	in	in	ADP
bibechana-25870	9	29	the	the	DET
bibechana-25870	9	30	surrounding	surrounding	NOUN
bibechana-25870	9	31	of	of	ADP
bibechana-25870	9	32	this	this	DET
bibechana-25870	9	33	domain	domain	NOUN
bibechana-25870	9	34	area	area	NOUN
bibechana-25870	9	35	.	.	PUNCT
bibechana-25870	10	1	this	this	PRON
bibechana-25870	10	2	is	be	AUX
bibechana-25870	10	3	a	a	DET
bibechana-25870	10	4	strong	strong	ADJ
bibechana-25870	10	5	evidence	evidence	NOUN
bibechana-25870	10	6	for	for	ADP
bibechana-25870	10	7	the	the	DET
bibechana-25870	10	8	mechanochemical	mechanochemical	ADJ
bibechana-25870	10	9	stability	stability	NOUN
bibechana-25870	10	10	of	of	ADP
bibechana-25870	10	11	a	a	DET
bibechana-25870	10	12	receptor	receptor	NOUN
bibechana-25870	10	13	protein	protein	NOUN
bibechana-25870	10	14	’s	’s	PART
bibechana-25870	10	15	lbd	lbd	PROPN
bibechana-25870	10	16	towards	towards	ADP
bibechana-25870	10	17	hormone	hormone	NOUN
bibechana-25870	10	18	activated	activate	VERB
bibechana-25870	10	19	gene	gene	NOUN
bibechana-25870	10	20	expressions	expression	NOUN
bibechana-25870	10	21	followed	follow	VERB
bibechana-25870	10	22	by	by	ADP
bibechana-25870	10	23	ligand	ligand	ADJ
bibechana-25870	10	24	binding	binding	NOUN
bibechana-25870	10	25	and	and	CCONJ
bibechana-25870	10	26	dissociation	dissociation	NOUN
bibechana-25870	10	27	.	.	PUNCT
bibechana-25870	11	1	1	1	X
bibechana-25870	11	2	.	.	X
bibechana-25870	11	3	introduction	introduction	NOUN
bibechana-25870	11	4	steered	steer	VERB
bibechana-25870	11	5	molecular	molecular	ADJ
bibechana-25870	11	6	dynamics	dynamic	NOUN
bibechana-25870	11	7	(	(	PUNCT
bibechana-25870	11	8	smd	smd	NOUN
bibechana-25870	11	9	)	)	PUNCT
bibechana-25870	11	10	is	be	AUX
bibechana-25870	11	11	used	use	VERB
bibechana-25870	11	12	to	to	PART
bibechana-25870	11	13	unfold	unfold	VERB
bibechana-25870	11	14	the	the	DET
bibechana-25870	11	15	proteins	protein	NOUN
bibechana-25870	11	16	and	and	CCONJ
bibechana-25870	11	17	to	to	PART
bibechana-25870	11	18	study	study	VERB
bibechana-25870	11	19	their	their	PRON
bibechana-25870	11	20	elastic	elastic	ADJ
bibechana-25870	11	21	properties	property	NOUN
bibechana-25870	11	22	visualizing	visualize	VERB
bibechana-25870	11	23	the	the	DET
bibechana-25870	11	24	different	different	ADJ
bibechana-25870	11	25	unfolding	unfold	VERB
bibechana-25870	11	26	pathways	pathway	NOUN
bibechana-25870	12	1	[	[	X
bibechana-25870	12	2	1	1	NUM
bibechana-25870	12	3	]	]	PUNCT
bibechana-25870	12	4	.	.	PUNCT
bibechana-25870	13	1	the	the	DET
bibechana-25870	13	2	biophysical	biophysical	ADJ
bibechana-25870	13	3	phenomena	phenomenon	NOUN
bibechana-25870	13	4	behind	behind	ADP
bibechana-25870	13	5	ligand	ligand	ADJ
bibechana-25870	13	6	binding	bind	VERB
bibechana-25870	13	7	,	,	PUNCT
bibechana-25870	13	8	dissociation	dissociation	NOUN
bibechana-25870	13	9	and	and	CCONJ
bibechana-25870	13	10	conformational	conformational	ADJ
bibechana-25870	13	11	changes	change	NOUN
bibechana-25870	13	12	of	of	ADP
bibechana-25870	13	13	thyroid	thyroid	NOUN
bibechana-25870	13	14	hormone	hormone	NOUN
bibechana-25870	13	15	receptors	receptor	NOUN
bibechana-25870	13	16	(	(	PUNCT
bibechana-25870	13	17	thr	thr	INTJ
bibechana-25870	13	18	)	)	PUNCT
bibechana-25870	13	19	are	be	AUX
bibechana-25870	13	20	important	important	ADJ
bibechana-25870	13	21	in	in	ADP
bibechana-25870	13	22	triiodothyronine	triiodothyronine	NOUN
bibechana-25870	13	23	(	(	PUNCT
bibechana-25870	13	24	t3	t3	NOUN
bibechana-25870	13	25	)	)	PUNCT
bibechana-25870	13	26	stimulated	stimulate	VERB
bibechana-25870	13	27	gene	gene	NOUN
bibechana-25870	13	28	expressions	expression	NOUN
bibechana-25870	13	29	[	[	X
bibechana-25870	13	30	2	2	NUM
bibechana-25870	13	31	]	]	PUNCT
bibechana-25870	13	32	.	.	PUNCT
bibechana-25870	14	1	the	the	DET
bibechana-25870	14	2	physical	physical	ADJ
bibechana-25870	14	3	properties	property	NOUN
bibechana-25870	14	4	such	such	ADJ
bibechana-25870	14	5	as	as	ADP
bibechana-25870	14	6	echo	echo	NOUN
bibechana-25870	14	7	dephasing	dephasing	NOUN
bibechana-25870	14	8	,	,	PUNCT
bibechana-25870	14	9	heat	heat	NOUN
bibechana-25870	14	10	capacity	capacity	NOUN
bibechana-25870	14	11	,	,	PUNCT
bibechana-25870	14	12	thermal	thermal	ADJ
bibechana-25870	14	13	diffusivity	diffusivity	NOUN
bibechana-25870	14	14	and	and	CCONJ
bibechana-25870	14	15	thermal	thermal	ADJ
bibechana-25870	14	16	conductivity	conductivity	NOUN
bibechana-25870	14	17	of	of	ADP
bibechana-25870	14	18	liganded	ligande	VERB
bibechana-25870	14	19	and/or	and/or	CCONJ
bibechana-25870	14	20	unliganded	unligande	VERB
bibechana-25870	14	21	thr	thr	PROPN
bibechana-25870	14	22	-	-	PUNCT
bibechana-25870	14	23	subtypes	subtype	NOUN
bibechana-25870	14	24	in	in	ADP
bibechana-25870	14	25	folding	fold	VERB
bibechana-25870	14	26	states	state	NOUN
bibechana-25870	14	27	are	be	AUX
bibechana-25870	14	28	previously	previously	ADV
bibechana-25870	14	29	studied	study	VERB
bibechana-25870	14	30	[	[	PUNCT
bibechana-25870	14	31	3	3	NUM
bibechana-25870	14	32	,	,	PUNCT
bibechana-25870	14	33	4	4	NUM
bibechana-25870	14	34	]	]	PUNCT
bibechana-25870	14	35	by	by	ADP
bibechana-25870	14	36	using	use	VERB
bibechana-25870	14	37	md	md	PROPN
bibechana-25870	14	38	simulations	simulation	NOUN
bibechana-25870	14	39	.	.	PUNCT
bibechana-25870	15	1	this	this	DET
bibechana-25870	15	2	work	work	NOUN
bibechana-25870	15	3	is	be	AUX
bibechana-25870	15	4	licensed	license	VERB
bibechana-25870	15	5	under	under	ADP
bibechana-25870	15	6	the	the	DET
bibechana-25870	15	7	creative	creative	ADJ
bibechana-25870	15	8	commons	common	NOUN
bibechana-25870	15	9	cc	cc	ADP
bibechana-25870	15	10	by	by	ADP
bibechana-25870	15	11	-	-	PUNCT
bibechana-25870	15	12	nc	nc	NOUN
bibechana-25870	15	13	license	license	NOUN
bibechana-25870	15	14	.	.	PUNCT
bibechana-25870	16	1	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	PRON
bibechana-25870	16	2	doi	doi	NOUN
bibechana-25870	16	3	:	:	PUNCT
bibechana-25870	16	4	https://doi.org/10.3126/bibechana.v17i0.25870	https://doi.org/10.3126/bibechana.v17i0.25870	NOUN
bibechana-25870	16	5	http://nepjol.info/index.php/bibechana	http://nepjol.info/index.php/bibechana	PROPN
bibechana-25870	16	6	mailto:tikaramlamichh@gmail.com	mailto:tikaramlamichh@gmail.com	X
bibechana-25870	16	7	https://creativecommons.org/licenses/by-nc/4.0/	https://creativecommons.org/licenses/by-nc/4.0/	X
bibechana-25870	16	8	https://doi.org/10.3126/bibechana.v17i0.25870	https://doi.org/10.3126/bibechana.v17i0.25870	NOUN
bibechana-25870	16	9	tika	tika	X
bibechana-25870	16	10	ram	ram	NOUN
bibechana-25870	16	11	lamichhane	lamichhane	NOUN
bibechana-25870	16	12	,	,	PUNCT
bibechana-25870	16	13	hari	hari	PROPN
bibechana-25870	16	14	prasad	prasad	PROPN
bibechana-25870	16	15	lamichhane	lamichhane	PROPN
bibechana-25870	16	16	/	/	SYM
bibechana-25870	16	17	bibechana	bibechana	PROPN
bibechana-25870	16	18	17	17	NUM
bibechana-25870	16	19	(	(	PUNCT
bibechana-25870	16	20	2020	2020	NUM
bibechana-25870	16	21	)	)	PUNCT
bibechana-25870	16	22	50	50	NUM
bibechana-25870	16	23	-	-	SYM
bibechana-25870	16	24	57	57	NUM
bibechana-25870	16	25	51	51	NUM
bibechana-25870	16	26	a	a	DET
bibechana-25870	16	27	point	point	NOUN
bibechana-25870	16	28	mutation	mutation	NOUN
bibechana-25870	16	29	in	in	ADP
bibechana-25870	16	30	thr-	thr-	ADJ
bibechana-25870	16	31	gene	gene	NOUN
bibechana-25870	16	32	causes	cause	VERB
bibechana-25870	16	33	resistance	resistance	NOUN
bibechana-25870	16	34	to	to	PART
bibechana-25870	16	35	thyroid	thyroid	VERB
bibechana-25870	16	36	hormones	hormone	NOUN
bibechana-25870	16	37	.	.	PUNCT
bibechana-25870	17	1	the	the	DET
bibechana-25870	17	2	mutational	mutational	ADJ
bibechana-25870	17	3	impacts	impact	NOUN
bibechana-25870	17	4	are	be	AUX
bibechana-25870	17	5	observed	observe	VERB
bibechana-25870	17	6	distinctly	distinctly	ADV
bibechana-25870	17	7	on	on	ADP
bibechana-25870	17	8	the	the	DET
bibechana-25870	17	9	protein	protein	NOUN
bibechana-25870	17	10	-	-	PUNCT
bibechana-25870	17	11	hormone	hormone	NOUN
bibechana-25870	17	12	systems	system	NOUN
bibechana-25870	17	13	by	by	ADP
bibechana-25870	17	14	analyzing	analyze	VERB
bibechana-25870	17	15	conformations	conformation	NOUN
bibechana-25870	17	16	and	and	CCONJ
bibechana-25870	17	17	interaction	interaction	NOUN
bibechana-25870	17	18	energies	energy	NOUN
bibechana-25870	17	19	through	through	ADP
bibechana-25870	17	20	molecular	molecular	ADJ
bibechana-25870	17	21	dynamics	dynamic	NOUN
bibechana-25870	17	22	approach	approach	NOUN
bibechana-25870	17	23	[	[	X
bibechana-25870	17	24	5	5	NUM
bibechana-25870	17	25	]	]	PUNCT
bibechana-25870	17	26	.	.	PUNCT
bibechana-25870	18	1	smd	smd	PROPN
bibechana-25870	18	2	is	be	AUX
bibechana-25870	18	3	a	a	DET
bibechana-25870	18	4	technique	technique	NOUN
bibechana-25870	18	5	to	to	PART
bibechana-25870	18	6	know	know	VERB
bibechana-25870	18	7	the	the	DET
bibechana-25870	18	8	structure	structure	NOUN
bibechana-25870	18	9	-	-	PUNCT
bibechana-25870	18	10	function	function	NOUN
bibechana-25870	18	11	relationships	relationship	NOUN
bibechana-25870	18	12	of	of	ADP
bibechana-25870	18	13	the	the	DET
bibechana-25870	18	14	protein	protein	NOUN
bibechana-25870	18	15	-	-	PUNCT
bibechana-25870	18	16	hormone	hormone	NOUN
bibechana-25870	18	17	complex	complex	NOUN
bibechana-25870	18	18	through	through	ADP
bibechana-25870	18	19	unbinding	unbinding	NOUN
bibechana-25870	18	20	of	of	ADP
bibechana-25870	18	21	hormone	hormone	NOUN
bibechana-25870	18	22	or	or	CCONJ
bibechana-25870	18	23	unfolding	unfolding	NOUN
bibechana-25870	18	24	of	of	ADP
bibechana-25870	18	25	protein	protein	NOUN
bibechana-25870	18	26	under	under	ADP
bibechana-25870	18	27	the	the	DET
bibechana-25870	18	28	application	application	NOUN
bibechana-25870	18	29	of	of	ADP
bibechana-25870	18	30	time	time	NOUN
bibechana-25870	18	31	-	-	PUNCT
bibechana-25870	18	32	dependent	dependent	ADJ
bibechana-25870	18	33	external	external	ADJ
bibechana-25870	18	34	forces	force	NOUN
bibechana-25870	18	35	.	.	PUNCT
bibechana-25870	19	1	the	the	DET
bibechana-25870	19	2	elastic	elastic	ADJ
bibechana-25870	19	3	properties	property	NOUN
bibechana-25870	19	4	of	of	ADP
bibechana-25870	19	5	the	the	DET
bibechana-25870	19	6	biomolecular	biomolecular	ADJ
bibechana-25870	19	7	systems	system	NOUN
bibechana-25870	19	8	subjected	subject	VERB
bibechana-25870	19	9	to	to	ADP
bibechana-25870	19	10	deformations	deformation	NOUN
bibechana-25870	19	11	by	by	ADP
bibechana-25870	19	12	smd	smd	NOUN
bibechana-25870	19	13	are	be	AUX
bibechana-25870	19	14	in	in	ADP
bibechana-25870	19	15	close	close	ADJ
bibechana-25870	19	16	agreement	agreement	NOUN
bibechana-25870	19	17	with	with	ADP
bibechana-25870	19	18	the	the	DET
bibechana-25870	19	19	experimental	experimental	ADJ
bibechana-25870	19	20	results	result	NOUN
bibechana-25870	19	21	obtained	obtain	VERB
bibechana-25870	19	22	from	from	ADP
bibechana-25870	19	23	atomic	atomic	ADJ
bibechana-25870	19	24	force	force	NOUN
bibechana-25870	19	25	microscopy	microscopy	NOUN
bibechana-25870	19	26	(	(	PUNCT
bibechana-25870	19	27	afm	afm	PROPN
bibechana-25870	19	28	)	)	PUNCT
bibechana-25870	19	29	and	and	CCONJ
bibechana-25870	19	30	optical	optical	ADJ
bibechana-25870	19	31	tweezers	tweezer	NOUN
bibechana-25870	19	32	[	[	X
bibechana-25870	19	33	6	6	NUM
bibechana-25870	19	34	-	-	SYM
bibechana-25870	19	35	8	8	NUM
bibechana-25870	19	36	]	]	PUNCT
bibechana-25870	19	37	.	.	PUNCT
bibechana-25870	20	1	the	the	DET
bibechana-25870	20	2	mechanical	mechanical	ADJ
bibechana-25870	20	3	stability	stability	NOUN
bibechana-25870	20	4	of	of	ADP
bibechana-25870	20	5	thyroid	thyroid	NOUN
bibechana-25870	20	6	hormone	hormone	NOUN
bibechana-25870	20	7	like	like	ADP
bibechana-25870	20	8	heavy	heavy	ADJ
bibechana-25870	20	9	ligand	ligand	ADJ
bibechana-25870	20	10	receptors	receptor	NOUN
bibechana-25870	20	11	is	be	AUX
bibechana-25870	20	12	governed	govern	VERB
bibechana-25870	20	13	by	by	ADP
bibechana-25870	20	14	protein	protein	NOUN
bibechana-25870	20	15	’s	’s	PART
bibechana-25870	20	16	secondary	secondary	ADJ
bibechana-25870	20	17	structure	structure	NOUN
bibechana-25870	20	18	and	and	CCONJ
bibechana-25870	20	19	pulling	pull	VERB
bibechana-25870	20	20	geometry	geometry	NOUN
bibechana-25870	20	21	[	[	X
bibechana-25870	20	22	9	9	NUM
bibechana-25870	20	23	]	]	PUNCT
bibechana-25870	20	24	.	.	PUNCT
bibechana-25870	21	1	thyroid	thyroid	NOUN
bibechana-25870	21	2	hormone	hormone	NOUN
bibechana-25870	21	3	dissociation	dissociation	NOUN
bibechana-25870	21	4	or	or	CCONJ
bibechana-25870	21	5	unfolding	unfolding	NOUN
bibechana-25870	21	6	of	of	ADP
bibechana-25870	21	7	thr	thr	PROPN
bibechana-25870	21	8	strands	strand	NOUN
bibechana-25870	21	9	proceeds	proceed	VERB
bibechana-25870	21	10	a	a	DET
bibechana-25870	21	11	frictional	frictional	ADJ
bibechana-25870	21	12	path	path	NOUN
bibechana-25870	21	13	with	with	ADP
bibechana-25870	21	14	constant	constant	ADJ
bibechana-25870	21	15	velocity	velocity	NOUN
bibechana-25870	21	16	along	along	ADP
bibechana-25870	21	17	x	x	NOUN
bibechana-25870	21	18	-	-	NOUN
bibechana-25870	21	19	direction	direction	NOUN
bibechana-25870	21	20	defined	define	VERB
bibechana-25870	21	21	by	by	ADP
bibechana-25870	21	22	langevin	langevin	PROPN
bibechana-25870	21	23	’s	’s	PART
bibechana-25870	21	24	equation	equation	NOUN
bibechana-25870	22	1	[	[	X
bibechana-25870	22	2	1	1	X
bibechana-25870	22	3	]	]	PUNCT
bibechana-25870	22	4	𝜇	𝜇	PART
bibechana-25870	22	5	�	�	PROPN
bibechana-25870	22	6	̇	̇	VERB
bibechana-25870	22	7	�	�	PROPN
bibechana-25870	22	8	=	=	SYM
bibechana-25870	22	9	−	−	PROPN
bibechana-25870	22	10	𝑑𝑈	𝑑𝑈	VERB
bibechana-25870	22	11	𝑑𝑥	𝑑𝑥	ADJ
bibechana-25870	22	12	+	+	ADJ
bibechana-25870	22	13	𝐹(𝑥	𝐹(𝑥	NUM
bibechana-25870	22	14	,	,	PUNCT
bibechana-25870	22	15	𝑡	𝑡	X
bibechana-25870	22	16	)	)	PUNCT
bibechana-25870	22	17	+	+	CCONJ
bibechana-25870	22	18	𝜎𝑓(𝑡	𝜎𝑓(𝑡	NOUN
bibechana-25870	22	19	)	)	PUNCT
bibechana-25870	22	20	(	(	PUNCT
bibechana-25870	22	21	1	1	X
bibechana-25870	22	22	)	)	PUNCT
bibechana-25870	22	23	where	where	SCONJ
bibechana-25870	22	24			NOUN
bibechana-25870	22	25	is	be	AUX
bibechana-25870	22	26	time	time	NOUN
bibechana-25870	22	27	dependent	dependent	ADJ
bibechana-25870	22	28	frictional	frictional	ADJ
bibechana-25870	22	29	coefficient	coefficient	NOUN
bibechana-25870	22	30	having	have	VERB
bibechana-25870	22	31	dimension	dimension	NOUN
bibechana-25870	22	32	of	of	ADP
bibechana-25870	22	33	[	[	X
bibechana-25870	22	34	mt	mt	PROPN
bibechana-25870	22	35	-1	-1	X
bibechana-25870	22	36	]	]	X
bibechana-25870	22	37	,	,	PUNCT
bibechana-25870	22	38	f(x	f(x	PROPN
bibechana-25870	22	39	,	,	PUNCT
bibechana-25870	22	40	t	t	PROPN
bibechana-25870	22	41	)	)	PUNCT
bibechana-25870	22	42	is	be	AUX
bibechana-25870	22	43	deforming	deform	VERB
bibechana-25870	22	44	force	force	NOUN
bibechana-25870	22	45	,	,	PUNCT
bibechana-25870	22	46	𝑈(𝑥	𝑈(𝑥	NOUN
bibechana-25870	22	47	)	)	PUNCT
bibechana-25870	22	48	is	be	AUX
bibechana-25870	22	49	potential	potential	ADJ
bibechana-25870	22	50	governing	govern	VERB
bibechana-25870	22	51	ligand	ligand	NOUN
bibechana-25870	22	52	dissociation	dissociation	NOUN
bibechana-25870	22	53	or	or	CCONJ
bibechana-25870	22	54	protein	protein	NOUN
bibechana-25870	22	55	unfolding	unfold	VERB
bibechana-25870	22	56	pathways	pathway	NOUN
bibechana-25870	22	57	and	and	CCONJ
bibechana-25870	22	58	𝑓(𝑡	𝑓(𝑡	NOUN
bibechana-25870	22	59	)	)	PUNCT
bibechana-25870	23	1	is	be	AUX
bibechana-25870	23	2	the	the	DET
bibechana-25870	23	3	stochastic	stochastic	ADJ
bibechana-25870	23	4	or	or	CCONJ
bibechana-25870	23	5	fluctuating	fluctuate	VERB
bibechana-25870	23	6	force	force	NOUN
bibechana-25870	23	7	term	term	NOUN
bibechana-25870	23	8	having	have	VERB
bibechana-25870	23	9	coupling	coupling	NOUN
bibechana-25870	23	10	coefficient	coefficient	VERB
bibechana-25870	23	11	𝜎.	𝜎.	NOUN
bibechana-25870	23	12	in	in	ADP
bibechana-25870	23	13	smd	smd	PROPN
bibechana-25870	23	14	simulation	simulation	NOUN
bibechana-25870	23	15	,	,	PUNCT
bibechana-25870	23	16	the	the	DET
bibechana-25870	23	17	smd	smd	NOUN
bibechana-25870	23	18	atom	atom	NOUN
bibechana-25870	23	19	is	be	AUX
bibechana-25870	23	20	attached	attach	VERB
bibechana-25870	23	21	to	to	ADP
bibechana-25870	23	22	a	a	DET
bibechana-25870	23	23	dummy	dummy	ADJ
bibechana-25870	23	24	atom	atom	NOUN
bibechana-25870	23	25	through	through	ADP
bibechana-25870	23	26	a	a	DET
bibechana-25870	23	27	virtual	virtual	ADJ
bibechana-25870	23	28	spring	spring	NOUN
bibechana-25870	23	29	.	.	PUNCT
bibechana-25870	24	1	in	in	ADP
bibechana-25870	24	2	one	one	NUM
bibechana-25870	24	3	dimensional	dimensional	ADJ
bibechana-25870	24	4	pulling	pulling	NOUN
bibechana-25870	24	5	,	,	PUNCT
bibechana-25870	24	6	the	the	DET
bibechana-25870	24	7	dummy	dummy	ADJ
bibechana-25870	24	8	atom	atom	NOUN
bibechana-25870	24	9	moves	move	NOUN
bibechana-25870	24	10	with	with	ADP
bibechana-25870	24	11	constant	constant	ADJ
bibechana-25870	24	12	velocity	velocity	NOUN
bibechana-25870	24	13	(	(	PUNCT
bibechana-25870	24	14	�	�	NOUN
bibechana-25870	24	15	⃗	⃗	NOUN
bibechana-25870	24	16	�	�	NOUN
bibechana-25870	24	17	=	=	SYM
bibechana-25870	24	18	𝑑	𝑑	PROPN
bibechana-25870	24	19	�	�	PROPN
bibechana-25870	24	20	⃗	⃗	NOUN
bibechana-25870	24	21	�	�	NOUN
bibechana-25870	24	22	/𝑑𝑡	/𝑑𝑡	NOUN
bibechana-25870	24	23	)	)	PUNCT
bibechana-25870	24	24	so	so	SCONJ
bibechana-25870	24	25	that	that	SCONJ
bibechana-25870	24	26	the	the	DET
bibechana-25870	24	27	smd	smd	NOUN
bibechana-25870	24	28	atom	atom	NOUN
bibechana-25870	24	29	experiences	experience	VERB
bibechana-25870	24	30	the	the	DET
bibechana-25870	24	31	force	force	PROPN
bibechana-25870	24	32	vector	vector	PROPN
bibechana-25870	24	33	�	�	PROPN
bibechana-25870	24	34	⃗	⃗	PROPN
bibechana-25870	24	35	�	�	PROPN
bibechana-25870	24	36	(𝑥	(𝑥	PROPN
bibechana-25870	24	37	,	,	PUNCT
bibechana-25870	24	38	𝑡	𝑡	NOUN
bibechana-25870	24	39	)	)	PUNCT
bibechana-25870	24	40	=	=	PUNCT
bibechana-25870	24	41	𝑘(	𝑘(	PROPN
bibechana-25870	24	42	�	�	PROPN
bibechana-25870	24	43	⃗	⃗	NOUN
bibechana-25870	24	44	�	�	PROPN
bibechana-25870	24	45	𝑡	𝑡	PART
bibechana-25870	24	46	−	−	PROPN
bibechana-25870	24	47	∆	∆	PROPN
bibechana-25870	24	48	�	�	PROPN
bibechana-25870	24	49	⃗	⃗	NOUN
bibechana-25870	24	50	�	�	PROPN
bibechana-25870	24	51	)	)	PUNCT
bibechana-25870	24	52	depending	depend	VERB
bibechana-25870	24	53	on	on	ADP
bibechana-25870	24	54	the	the	DET
bibechana-25870	24	55	linear	linear	ADJ
bibechana-25870	24	56	distance	distance	NOUN
bibechana-25870	24	57	between	between	ADP
bibechana-25870	24	58	these	these	DET
bibechana-25870	24	59	atoms	atom	NOUN
bibechana-25870	24	60	[	[	X
bibechana-25870	24	61	10	10	NUM
bibechana-25870	24	62	]	]	PUNCT
bibechana-25870	24	63	.	.	PUNCT
bibechana-25870	25	1	so	so	ADV
bibechana-25870	25	2	,	,	PUNCT
bibechana-25870	25	3	the	the	DET
bibechana-25870	25	4	external	external	ADJ
bibechana-25870	25	5	potential	potential	ADJ
bibechana-25870	25	6	energy	energy	NOUN
bibechana-25870	25	7	[	[	X
bibechana-25870	25	8	11	11	NUM
bibechana-25870	25	9	]	]	PUNCT
bibechana-25870	25	10	is	be	AUX
bibechana-25870	25	11	given	give	VERB
bibechana-25870	25	12	by	by	ADP
bibechana-25870	25	13	𝑈(𝑥	𝑈(𝑥	NUM
bibechana-25870	25	14	,	,	PUNCT
bibechana-25870	25	15	𝑡	𝑡	NOUN
bibechana-25870	25	16	)	)	PUNCT
bibechana-25870	25	17	=	=	SYM
bibechana-25870	25	18	1	1	NUM
bibechana-25870	25	19	2	2	NUM
bibechana-25870	25	20	𝑘[(	𝑘[(	PROPN
bibechana-25870	25	21	�	�	PROPN
bibechana-25870	25	22	⃗	⃗	NOUN
bibechana-25870	25	23	�	�	PROPN
bibechana-25870	25	24	𝑡	𝑡	PART
bibechana-25870	25	25	−	−	PROPN
bibechana-25870	25	26	∆	∆	PROPN
bibechana-25870	25	27	�	�	PROPN
bibechana-25870	25	28	⃗	⃗	NOUN
bibechana-25870	25	29	�	�	PROPN
bibechana-25870	25	30	)	)	PUNCT
bibechana-25870	25	31	.	.	PUNCT
bibechana-25870	26	1	�	�	PROPN
bibechana-25870	26	2	⃗⃗	⃗⃗	PROPN
bibechana-25870	26	3	�	�	PROPN
bibechana-25870	26	4	]2	]2	X
bibechana-25870	26	5	(	(	PUNCT
bibechana-25870	26	6	2	2	NUM
bibechana-25870	26	7	)	)	PUNCT
bibechana-25870	26	8	where	where	SCONJ
bibechana-25870	26	9	𝑘	𝑘	NOUN
bibechana-25870	26	10	is	be	AUX
bibechana-25870	26	11	spring	spring	NOUN
bibechana-25870	26	12	constant	constant	ADJ
bibechana-25870	26	13	that	that	PRON
bibechana-25870	26	14	specifies	specify	VERB
bibechana-25870	26	15	the	the	DET
bibechana-25870	26	16	stiffness	stiffness	NOUN
bibechana-25870	26	17	of	of	ADP
bibechana-25870	26	18	the	the	DET
bibechana-25870	26	19	applied	apply	VERB
bibechana-25870	26	20	harmonic	harmonic	ADJ
bibechana-25870	26	21	restraining	restraining	NOUN
bibechana-25870	26	22	force	force	NOUN
bibechana-25870	26	23	,	,	PUNCT
bibechana-25870	26	24	∆	∆	PROPN
bibechana-25870	26	25	�	�	PROPN
bibechana-25870	26	26	⃗	⃗	PROPN
bibechana-25870	26	27	�	�	PROPN
bibechana-25870	26	28	(𝑡	(𝑡	SYM
bibechana-25870	26	29	)	)	PUNCT
bibechana-25870	26	30	=	=	SYM
bibechana-25870	26	31	�	�	PROPN
bibechana-25870	26	32	⃗	⃗	PROPN
bibechana-25870	26	33	�	�	PROPN
bibechana-25870	26	34	(𝑡	(𝑡	SYM
bibechana-25870	26	35	)	)	PUNCT
bibechana-25870	26	36	−	−	PROPN
bibechana-25870	26	37	�	�	PROPN
bibechana-25870	26	38	⃗	⃗	NOUN
bibechana-25870	26	39	�	�	NOUN
bibechana-25870	26	40	0	0	NUM
bibechana-25870	26	41	is	be	AUX
bibechana-25870	26	42	tagged	tag	VERB
bibechana-25870	26	43	group	group	NOUN
bibechana-25870	26	44	displacement	displacement	NOUN
bibechana-25870	26	45	with	with	ADP
bibechana-25870	26	46	�	�	PROPN
bibechana-25870	26	47	⃗	⃗	NOUN
bibechana-25870	26	48	�	�	NOUN
bibechana-25870	26	49	(𝑡	(𝑡	NOUN
bibechana-25870	26	50	)	)	PUNCT
bibechana-25870	26	51	and	and	CCONJ
bibechana-25870	26	52	�	�	PROPN
bibechana-25870	26	53	⃗	⃗	NOUN
bibechana-25870	26	54	�	�	NOUN
bibechana-25870	26	55	0	0	NUM
bibechana-25870	26	56	being	be	AUX
bibechana-25870	26	57	actual	actual	ADJ
bibechana-25870	26	58	and	and	CCONJ
bibechana-25870	26	59	initial	initial	ADJ
bibechana-25870	26	60	positions	position	NOUN
bibechana-25870	26	61	of	of	ADP
bibechana-25870	26	62	the	the	DET
bibechana-25870	26	63	smd	smd	NOUN
bibechana-25870	26	64	atom	atom	NOUN
bibechana-25870	26	65	and	and	CCONJ
bibechana-25870	26	66	�	�	PROPN
bibechana-25870	26	67	⃗⃗	⃗⃗	PROPN
bibechana-25870	26	68	�	�	PROPN
bibechana-25870	26	69	is	be	AUX
bibechana-25870	26	70	the	the	DET
bibechana-25870	26	71	direction	direction	NOUN
bibechana-25870	26	72	of	of	ADP
bibechana-25870	26	73	pulling	pull	VERB
bibechana-25870	26	74	.	.	PUNCT
bibechana-25870	27	1	2	2	X
bibechana-25870	27	2	.	.	X
bibechana-25870	27	3	methodology	methodology	NOUN
bibechana-25870	27	4	the	the	DET
bibechana-25870	27	5	initial	initial	ADJ
bibechana-25870	27	6	structure	structure	NOUN
bibechana-25870	27	7	of	of	ADP
bibechana-25870	27	8	t3	t3	PROPN
bibechana-25870	27	9	-	-	PUNCT
bibechana-25870	27	10	liganded	ligande	VERB
bibechana-25870	27	11	thr-	thr-	ADJ
bibechana-25870	27	12	isoform	isoform	NOUN
bibechana-25870	27	13	of	of	ADP
bibechana-25870	27	14	nuclear	nuclear	ADJ
bibechana-25870	27	15	receptor	receptor	NOUN
bibechana-25870	27	16	super	super	ADJ
bibechana-25870	27	17	family	family	NOUN
bibechana-25870	27	18	was	be	AUX
bibechana-25870	27	19	taken	take	VERB
bibechana-25870	27	20	from	from	ADP
bibechana-25870	27	21	the	the	DET
bibechana-25870	27	22	protein	protein	NOUN
bibechana-25870	27	23	data	data	PROPN
bibechana-25870	27	24	bank	bank	PROPN
bibechana-25870	27	25	code	code	PROPN
bibechana-25870	27	26	3gws	3gws	PROPN
bibechana-25870	28	1	[	[	X
bibechana-25870	28	2	12	12	NUM
bibechana-25870	28	3	]	]	PUNCT
bibechana-25870	28	4	.	.	PUNCT
bibechana-25870	29	1	the	the	DET
bibechana-25870	29	2	thr-	thr-	ADJ
bibechana-25870	29	3	ligand	ligand	NOUN
bibechana-25870	29	4	binding	bind	VERB
bibechana-25870	29	5	domain	domain	NOUN
bibechana-25870	29	6	(	(	PUNCT
bibechana-25870	29	7	lbd	lbd	NOUN
bibechana-25870	29	8	)	)	PUNCT
bibechana-25870	29	9	complex	complex	NOUN
bibechana-25870	29	10	has	have	VERB
bibechana-25870	29	11	the	the	DET
bibechana-25870	29	12	chain	chain	NOUN
bibechana-25870	29	13	length	length	NOUN
bibechana-25870	29	14	of	of	ADP
bibechana-25870	29	15	-helices	-helices	PROPN
bibechana-25870	29	16	and	and	CCONJ
bibechana-25870	29	17	-forms	-forms	PROPN
bibechana-25870	29	18	with	with	ADP
bibechana-25870	29	19	259	259	NUM
bibechana-25870	29	20	amino	amino	ADJ
bibechana-25870	29	21	acids	acid	NOUN
bibechana-25870	29	22	and	and	CCONJ
bibechana-25870	29	23	3895	3895	NUM
bibechana-25870	29	24	atoms	atom	NOUN
bibechana-25870	29	25	.	.	PUNCT
bibechana-25870	30	1	in	in	ADP
bibechana-25870	30	2	the	the	DET
bibechana-25870	30	3	folding	fold	VERB
bibechana-25870	30	4	state	state	NOUN
bibechana-25870	30	5	or	or	CCONJ
bibechana-25870	30	6	the	the	DET
bibechana-25870	30	7	globular	globular	ADJ
bibechana-25870	30	8	form	form	NOUN
bibechana-25870	30	9	,	,	PUNCT
bibechana-25870	30	10	end	end	VERB
bibechana-25870	30	11	to	to	PART
bibechana-25870	30	12	end	end	VERB
bibechana-25870	30	13	distance	distance	NOUN
bibechana-25870	30	14	of	of	ADP
bibechana-25870	30	15	thr-	thr-	PROPN
bibechana-25870	30	16	lbd	lbd	PROPN
bibechana-25870	30	17	is	be	AUX
bibechana-25870	30	18	38	38	NUM
bibechana-25870	30	19	å	å	NOUN
bibechana-25870	30	20	.	.	PUNCT
bibechana-25870	31	1	the	the	DET
bibechana-25870	31	2	thr-	thr-	PROPN
bibechana-25870	31	3	lbd	lbd	PROPN
bibechana-25870	31	4	actively	actively	ADV
bibechana-25870	31	5	binds	bind	VERB
bibechana-25870	31	6	t3	t3	PROPN
bibechana-25870	31	7	hormones	hormone	NOUN
bibechana-25870	31	8	having	have	VERB
bibechana-25870	31	9	35	35	NUM
bibechana-25870	31	10	atoms	atom	NOUN
bibechana-25870	31	11	including	include	VERB
bibechana-25870	31	12	3	3	NUM
bibechana-25870	31	13	iodine	iodine	NOUN
bibechana-25870	31	14	atoms	atom	NOUN
bibechana-25870	31	15	.	.	PUNCT
bibechana-25870	32	1	the	the	DET
bibechana-25870	32	2	simulation	simulation	NOUN
bibechana-25870	32	3	packages	package	NOUN
bibechana-25870	32	4	such	such	ADJ
bibechana-25870	32	5	as	as	ADP
bibechana-25870	32	6	protein	protein	NOUN
bibechana-25870	32	7	structure	structure	NOUN
bibechana-25870	32	8	file	file	NOUN
bibechana-25870	32	9	(	(	PUNCT
bibechana-25870	32	10	psf	psf	ADJ
bibechana-25870	32	11	)	)	PUNCT
bibechana-25870	32	12	generation	generation	NOUN
bibechana-25870	32	13	and	and	CCONJ
bibechana-25870	32	14	solvation	solvation	NOUN
bibechana-25870	32	15	with	with	ADP
bibechana-25870	32	16	water	water	NOUN
bibechana-25870	32	17	(	(	PUNCT
bibechana-25870	32	18	tip3p	tip3p	ADP
bibechana-25870	32	19	model	model	NOUN
bibechana-25870	32	20	)	)	PUNCT
bibechana-25870	32	21	and	and	CCONJ
bibechana-25870	32	22	ions	ion	NOUN
bibechana-25870	32	23	providing	provide	VERB
bibechana-25870	32	24	cellular	cellular	ADJ
bibechana-25870	32	25	environment	environment	NOUN
bibechana-25870	32	26	were	be	AUX
bibechana-25870	32	27	prepared	prepared	ADJ
bibechana-25870	32	28	and	and	CCONJ
bibechana-25870	32	29	structural	structural	ADJ
bibechana-25870	32	30	and	and	CCONJ
bibechana-25870	32	31	graphical	graphical	ADJ
bibechana-25870	32	32	analysis	analysis	NOUN
bibechana-25870	32	33	were	be	AUX
bibechana-25870	32	34	performed	perform	VERB
bibechana-25870	32	35	by	by	ADP
bibechana-25870	32	36	using	use	VERB
bibechana-25870	32	37	visual	visual	ADJ
bibechana-25870	32	38	molecular	molecular	ADJ
bibechana-25870	32	39	dynamics	dynamic	NOUN
bibechana-25870	32	40	(	(	PUNCT
bibechana-25870	32	41	vmd-1.9.3	vmd-1.9.3	NOUN
bibechana-25870	32	42	)	)	PUNCT
bibechana-25870	33	1	[	[	X
bibechana-25870	33	2	13	13	NUM
bibechana-25870	33	3	]	]	PUNCT
bibechana-25870	33	4	.	.	PUNCT
bibechana-25870	34	1	in	in	ADP
bibechana-25870	34	2	accordance	accordance	NOUN
bibechana-25870	34	3	with	with	ADP
bibechana-25870	34	4	nanoscale	nanoscale	NOUN
bibechana-25870	34	5	molecular	molecular	ADJ
bibechana-25870	34	6	dynamics	dynamic	NOUN
bibechana-25870	34	7	(	(	PUNCT
bibechana-25870	34	8	namd-2.12	namd-2.12	X
bibechana-25870	34	9	)	)	PUNCT
bibechana-25870	34	10	protocols	protocol	NOUN
bibechana-25870	34	11	[	[	X
bibechana-25870	34	12	14	14	NUM
bibechana-25870	34	13	]	]	PUNCT
bibechana-25870	34	14	,	,	PUNCT
bibechana-25870	34	15	the	the	DET
bibechana-25870	34	16	topologies	topology	NOUN
bibechana-25870	34	17	and	and	CCONJ
bibechana-25870	34	18	parameters	parameter	NOUN
bibechana-25870	34	19	required	require	VERB
bibechana-25870	34	20	for	for	ADP
bibechana-25870	34	21	md	md	PROPN
bibechana-25870	34	22	simulations	simulation	NOUN
bibechana-25870	34	23	of	of	ADP
bibechana-25870	34	24	the	the	DET
bibechana-25870	34	25	thr-	thr-	PROPN
bibechana-25870	34	26	lbd	lbd	PROPN
bibechana-25870	34	27	complex	complex	NOUN
bibechana-25870	34	28	were	be	AUX
bibechana-25870	34	29	obtained	obtain	VERB
bibechana-25870	34	30	from	from	ADP
bibechana-25870	34	31	charmm	charmm	NOUN
bibechana-25870	34	32	force	force	NOUN
bibechana-25870	34	33	fields	field	NOUN
bibechana-25870	34	34	for	for	ADP
bibechana-25870	34	35	proteins	protein	NOUN
bibechana-25870	34	36	[	[	X
bibechana-25870	34	37	15	15	NUM
bibechana-25870	34	38	,	,	PUNCT
bibechana-25870	34	39	16	16	NUM
bibechana-25870	34	40	]	]	PUNCT
bibechana-25870	34	41	.	.	PUNCT
bibechana-25870	35	1	the	the	DET
bibechana-25870	35	2	t3	t3	NOUN
bibechana-25870	35	3	-	-	PUNCT
bibechana-25870	35	4	hormone	hormone	NOUN
bibechana-25870	35	5	was	be	AUX
bibechana-25870	35	6	parameterized	parameterized	ADJ
bibechana-25870	35	7	with	with	ADP
bibechana-25870	35	8	the	the	DET
bibechana-25870	35	9	help	help	NOUN
bibechana-25870	35	10	of	of	ADP
bibechana-25870	35	11	zoete	zoete	PROPN
bibechana-25870	35	12	’s	’s	PART
bibechana-25870	35	13	force	force	PROPN
bibechana-25870	35	14	field	field	NOUN
bibechana-25870	35	15	generation	generation	NOUN
bibechana-25870	35	16	tool	tool	NOUN
bibechana-25870	35	17	[	[	X
bibechana-25870	35	18	17	17	NUM
bibechana-25870	35	19	]	]	PUNCT
bibechana-25870	35	20	.	.	PUNCT
bibechana-25870	36	1	the	the	DET
bibechana-25870	36	2	t3	t3	NOUN
bibechana-25870	36	3	-	-	PUNCT
bibechana-25870	36	4	liganded	ligande	VERB
bibechana-25870	36	5	thr-	thr-	PROPN
bibechana-25870	36	6	lbd	lbd	PROPN
bibechana-25870	36	7	(	(	PUNCT
bibechana-25870	36	8	thrt3	thrt3	NOUN
bibechana-25870	36	9	)	)	PUNCT
bibechana-25870	36	10	was	be	AUX
bibechana-25870	36	11	fully	fully	ADV
bibechana-25870	36	12	solvated	solvate	VERB
bibechana-25870	36	13	into	into	ADP
bibechana-25870	36	14	a	a	DET
bibechana-25870	36	15	water	water	NOUN
bibechana-25870	36	16	droplet	droplet	NOUN
bibechana-25870	36	17	of	of	ADP
bibechana-25870	36	18	radius	radius	NOUN
bibechana-25870	36	19	37.5	37.5	NUM
bibechana-25870	36	20	å	å	NOUN
bibechana-25870	36	21	consisting	consist	VERB
bibechana-25870	36	22	of	of	ADP
bibechana-25870	36	23	17245	17245	NUM
bibechana-25870	36	24	water	water	NOUN
bibechana-25870	36	25	molecules	molecule	NOUN
bibechana-25870	36	26	neutralized	neutralize	VERB
bibechana-25870	36	27	with	with	ADP
bibechana-25870	36	28	26	26	NUM
bibechana-25870	36	29	na	na	NOUN
bibechana-25870	36	30	+	+	NUM
bibechana-25870	37	1	and	and	CCONJ
bibechana-25870	37	2	16	16	NUM
bibechana-25870	37	3	cl	cl	NOUN
bibechana-25870	37	4	ions	ion	NOUN
bibechana-25870	37	5	in	in	ADP
bibechana-25870	37	6	the	the	DET
bibechana-25870	37	7	concentrations	concentration	NOUN
bibechana-25870	37	8	of	of	ADP
bibechana-25870	37	9	0.15	0.15	NUM
bibechana-25870	37	10	mol	mol	NOUN
bibechana-25870	37	11	/	/	SYM
bibechana-25870	37	12	l.	l.	PROPN
bibechana-25870	37	13	the	the	DET
bibechana-25870	37	14	system	system	NOUN
bibechana-25870	37	15	’s	’s	PART
bibechana-25870	37	16	energy	energy	NOUN
bibechana-25870	37	17	was	be	AUX
bibechana-25870	37	18	minimized	minimize	VERB
bibechana-25870	37	19	up	up	ADP
bibechana-25870	37	20	to	to	PART
bibechana-25870	37	21	3000	3000	NUM
bibechana-25870	37	22	conjugate	conjugate	ADJ
bibechana-25870	37	23	gradient	gradient	NOUN
bibechana-25870	37	24	steps	step	NOUN
bibechana-25870	37	25	and	and	CCONJ
bibechana-25870	37	26	it	it	PRON
bibechana-25870	37	27	was	be	AUX
bibechana-25870	37	28	equilibrated	equilibrate	VERB
bibechana-25870	37	29	up	up	ADP
bibechana-25870	37	30	to	to	PART
bibechana-25870	37	31	20	20	NUM
bibechana-25870	37	32	ns	ns	NUM
bibechana-25870	37	33	with	with	ADP
bibechana-25870	37	34	namd	namd	ADJ
bibechana-25870	37	35	protocols	protocol	NOUN
bibechana-25870	37	36	.	.	PUNCT
bibechana-25870	38	1	velocity	velocity	NOUN
bibechana-25870	38	2	verlet	verlet	NOUN
bibechana-25870	38	3	algorithm	algorithm	NOUN
bibechana-25870	38	4	[	[	X
bibechana-25870	38	5	18	18	NUM
bibechana-25870	38	6	]	]	PUNCT
bibechana-25870	38	7	was	be	AUX
bibechana-25870	38	8	used	use	VERB
bibechana-25870	38	9	for	for	ADP
bibechana-25870	38	10	the	the	DET
bibechana-25870	38	11	equilibration	equilibration	NOUN
bibechana-25870	38	12	simulations	simulation	NOUN
bibechana-25870	38	13	with	with	ADP
bibechana-25870	38	14	the	the	DET
bibechana-25870	38	15	integrator	integrator	NOUN
bibechana-25870	38	16	parameter	parameter	NOUN
bibechana-25870	38	17	of	of	ADP
bibechana-25870	38	18	2	2	NUM
bibechana-25870	38	19	fs	fs	NOUN
bibechana-25870	38	20	/	/	SYM
bibechana-25870	38	21	step	step	NOUN
bibechana-25870	38	22	,	,	PUNCT
bibechana-25870	38	23	langevin	langevin	NOUN
bibechana-25870	38	24	thermostat	thermostat	NOUN
bibechana-25870	38	25	at	at	ADP
bibechana-25870	38	26	310	310	NUM
bibechana-25870	38	27	k	k	NOUN
bibechana-25870	38	28	and	and	CCONJ
bibechana-25870	38	29	barostat	barostat	NOUN
bibechana-25870	38	30	at	at	ADP
bibechana-25870	38	31	1	1	NUM
bibechana-25870	38	32	-	-	PUNCT
bibechana-25870	38	33	atm	atm	NOUN
bibechana-25870	38	34	and	and	CCONJ
bibechana-25870	38	35	damping	damp	VERB
bibechana-25870	38	36	coefficient	coefficient	NOUN
bibechana-25870	38	37	of	of	ADP
bibechana-25870	38	38	1	1	NUM
bibechana-25870	38	39	ps	ps	NOUN
bibechana-25870	38	40	-1	-1	NOUN
bibechana-25870	38	41	.	.	PUNCT
bibechana-25870	39	1	for	for	ADP
bibechana-25870	39	2	the	the	DET
bibechana-25870	39	3	lenard	lenard	NOUN
bibechana-25870	39	4	-	-	PUNCT
bibechana-25870	39	5	jones	jones	NOUN
bibechana-25870	39	6	interactions	interaction	NOUN
bibechana-25870	39	7	,	,	PUNCT
bibechana-25870	39	8	a	a	DET
bibechana-25870	39	9	12	12	NUM
bibechana-25870	39	10	å	å	PROPN
bibechana-25870	39	11	cut	cut	NOUN
bibechana-25870	39	12	-	-	PUNCT
bibechana-25870	39	13	off	off	NOUN
bibechana-25870	39	14	with	with	ADP
bibechana-25870	39	15	smooth	smooth	ADJ
bibechana-25870	39	16	switching	switching	NOUN
bibechana-25870	39	17	function	function	NOUN
bibechana-25870	39	18	starting	start	VERB
bibechana-25870	39	19	at	at	ADP
bibechana-25870	39	20	10	10	NUM
bibechana-25870	39	21	å	å	PROPN
bibechana-25870	39	22	was	be	AUX
bibechana-25870	39	23	applied	apply	VERB
bibechana-25870	39	24	with	with	ADP
bibechana-25870	39	25	1	1	NUM
bibechana-25870	39	26	-	-	SYM
bibechana-25870	39	27	4	4	NUM
bibechana-25870	39	28	scaling	scale	VERB
bibechana-25870	39	29	1.0	1.0	NUM
bibechana-25870	39	30	.	.	PUNCT
bibechana-25870	40	1	the	the	DET
bibechana-25870	40	2	final	final	ADJ
bibechana-25870	40	3	coordinates	coordinate	NOUN
bibechana-25870	40	4	of	of	ADP
bibechana-25870	40	5	the	the	DET
bibechana-25870	40	6	solvated	solvated	ADJ
bibechana-25870	40	7	thrt3	thrt3	NOUN
bibechana-25870	40	8	were	be	AUX
bibechana-25870	40	9	extracted	extract	VERB
bibechana-25870	40	10	from	from	ADP
bibechana-25870	40	11	the	the	DET
bibechana-25870	40	12	equilibrated	equilibrate	VERB
bibechana-25870	40	13	droplet	droplet	NOUN
bibechana-25870	40	14	in	in	ADP
bibechana-25870	40	15	order	order	NOUN
bibechana-25870	40	16	to	to	PART
bibechana-25870	40	17	perform	perform	VERB
bibechana-25870	40	18	smd	smd	NOUN
bibechana-25870	40	19	simulations	simulation	NOUN
bibechana-25870	40	20	.	.	PUNCT
bibechana-25870	41	1	the	the	DET
bibechana-25870	41	2	smd	smd	PROPN
bibechana-25870	41	3	simulation	simulation	NOUN
bibechana-25870	41	4	was	be	AUX
bibechana-25870	41	5	conducted	conduct	VERB
bibechana-25870	41	6	setting	set	VERB
bibechana-25870	41	7	the	the	DET
bibechana-25870	41	8	c	c	NOUN
bibechana-25870	41	9	atom	atom	NOUN
bibechana-25870	41	10	of	of	ADP
bibechana-25870	41	11	the	the	DET
bibechana-25870	41	12	last	last	ADJ
bibechana-25870	41	13	residue-460	residue-460	NOUN
bibechana-25870	41	14	as	as	ADP
bibechana-25870	41	15	the	the	DET
bibechana-25870	41	16	smd	smd	NOUN
bibechana-25870	41	17	atom	atom	NOUN
bibechana-25870	41	18	and	and	CCONJ
bibechana-25870	41	19	the	the	DET
bibechana-25870	41	20	c	c	PROPN
bibechana-25870	41	21	atom	atom	NOUN
bibechana-25870	41	22	of	of	ADP
bibechana-25870	41	23	the	the	DET
bibechana-25870	41	24	first	first	ADJ
bibechana-25870	41	25	residue-202	residue-202	NOUN
bibechana-25870	41	26	as	as	ADP
bibechana-25870	41	27	the	the	DET
bibechana-25870	41	28	fixed	fix	VERB
bibechana-25870	41	29	tika	tika	X
bibechana-25870	41	30	ram	ram	NOUN
bibechana-25870	41	31	lamichhane	lamichhane	NOUN
bibechana-25870	41	32	,	,	PUNCT
bibechana-25870	41	33	hari	hari	PROPN
bibechana-25870	41	34	prasad	prasad	PROPN
bibechana-25870	41	35	lamichhane	lamichhane	PROPN
bibechana-25870	41	36	/	/	SYM
bibechana-25870	41	37	bibechana	bibechana	PROPN
bibechana-25870	41	38	17	17	NUM
bibechana-25870	41	39	(	(	PUNCT
bibechana-25870	41	40	2020	2020	NUM
bibechana-25870	41	41	)	)	PUNCT
bibechana-25870	41	42	50	50	NUM
bibechana-25870	41	43	-	-	SYM
bibechana-25870	41	44	57	57	NUM
bibechana-25870	41	45	52	52	NUM
bibechana-25870	41	46	atom	atom	NOUN
bibechana-25870	41	47	.	.	PUNCT
bibechana-25870	42	1	the	the	DET
bibechana-25870	42	2	virtual	virtual	ADJ
bibechana-25870	42	3	spring	spring	NOUN
bibechana-25870	42	4	between	between	ADP
bibechana-25870	42	5	the	the	DET
bibechana-25870	42	6	smd	smd	NOUN
bibechana-25870	42	7	atom	atom	NOUN
bibechana-25870	42	8	and	and	CCONJ
bibechana-25870	42	9	the	the	DET
bibechana-25870	42	10	dummy	dummy	ADJ
bibechana-25870	42	11	atom	atom	NOUN
bibechana-25870	42	12	was	be	AUX
bibechana-25870	42	13	7	7	NUM
bibechana-25870	42	14	kcal	kcal	NOUN
bibechana-25870	42	15	/	/	SYM
bibechana-25870	42	16	mol/	mol/	NOUN
bibechana-25870	42	17	å	å	PROPN
bibechana-25870	42	18	2	2	NUM
bibechana-25870	42	19	.	.	PUNCT
bibechana-25870	43	1	the	the	DET
bibechana-25870	43	2	one	one	NUM
bibechana-25870	43	3	dimensional	dimensional	ADJ
bibechana-25870	43	4	pulling	pulling	NOUN
bibechana-25870	43	5	was	be	AUX
bibechana-25870	43	6	performed	perform	VERB
bibechana-25870	43	7	at	at	ADP
bibechana-25870	43	8	constant	constant	ADJ
bibechana-25870	43	9	velocity	velocity	NOUN
bibechana-25870	43	10	of	of	ADP
bibechana-25870	43	11	0.1	0.1	NUM
bibechana-25870	43	12	å	å	NOUN
bibechana-25870	43	13	/	/	SYM
bibechana-25870	43	14	ps	ps	NOUN
bibechana-25870	43	15	in	in	ADP
bibechana-25870	43	16	the	the	DET
bibechana-25870	43	17	direction	direction	NOUN
bibechana-25870	43	18	along	along	ADP
bibechana-25870	43	19	a	a	DET
bibechana-25870	43	20	vector	vector	NOUN
bibechana-25870	43	21	connecting	connect	VERB
bibechana-25870	43	22	the	the	DET
bibechana-25870	43	23	fixed	fix	VERB
bibechana-25870	43	24	atom	atom	NOUN
bibechana-25870	43	25	and	and	CCONJ
bibechana-25870	43	26	the	the	DET
bibechana-25870	43	27	smd	smd	NOUN
bibechana-25870	43	28	atom	atom	NOUN
bibechana-25870	43	29	.	.	PUNCT
bibechana-25870	44	1	the	the	DET
bibechana-25870	44	2	thrt3	thrt3	PROPN
bibechana-25870	44	3	complex	complex	NOUN
bibechana-25870	44	4	became	became	AUX
bibechana-25870	44	5	completely	completely	ADV
bibechana-25870	44	6	unfolded	unfold	VERB
bibechana-25870	44	7	at	at	ADP
bibechana-25870	44	8	the	the	DET
bibechana-25870	44	9	simulation	simulation	NOUN
bibechana-25870	44	10	time	time	NOUN
bibechana-25870	44	11	of	of	ADP
bibechana-25870	44	12	about	about	ADV
bibechana-25870	44	13	8.5	8.5	NUM
bibechana-25870	44	14	ns	ns	NUM
bibechana-25870	44	15	and	and	CCONJ
bibechana-25870	44	16	the	the	DET
bibechana-25870	44	17	smd	smd	NOUN
bibechana-25870	44	18	was	be	AUX
bibechana-25870	44	19	conducted	conduct	VERB
bibechana-25870	44	20	up	up	ADP
bibechana-25870	44	21	to	to	PART
bibechana-25870	44	22	10	10	NUM
bibechana-25870	44	23	ns	ns	NUM
bibechana-25870	44	24	.	.	PUNCT
bibechana-25870	45	1	the	the	DET
bibechana-25870	45	2	intermediate	intermediate	ADJ
bibechana-25870	45	3	conformational	conformational	ADJ
bibechana-25870	45	4	states	state	NOUN
bibechana-25870	45	5	of	of	ADP
bibechana-25870	45	6	the	the	DET
bibechana-25870	45	7	thrt3	thrt3	PROPN
bibechana-25870	45	8	structures	structure	NOUN
bibechana-25870	45	9	were	be	AUX
bibechana-25870	45	10	visualized	visualize	VERB
bibechana-25870	45	11	and	and	CCONJ
bibechana-25870	45	12	the	the	DET
bibechana-25870	45	13	images	image	NOUN
bibechana-25870	45	14	were	be	AUX
bibechana-25870	45	15	generated	generate	VERB
bibechana-25870	45	16	by	by	ADP
bibechana-25870	45	17	using	use	VERB
bibechana-25870	45	18	the	the	DET
bibechana-25870	45	19	vmd	vmd	PROPN
bibechana-25870	45	20	software	software	PROPN
bibechana-25870	45	21	.	.	PUNCT
bibechana-25870	46	1	the	the	DET
bibechana-25870	46	2	related	relate	VERB
bibechana-25870	46	3	physical	physical	ADJ
bibechana-25870	46	4	parameters	parameter	NOUN
bibechana-25870	46	5	such	such	ADJ
bibechana-25870	46	6	as	as	ADP
bibechana-25870	46	7	radius	radius	NOUN
bibechana-25870	46	8	of	of	ADP
bibechana-25870	46	9	gyration	gyration	NOUN
bibechana-25870	46	10	(	(	PUNCT
bibechana-25870	46	11	rg	rg	NOUN
bibechana-25870	46	12	)	)	PUNCT
bibechana-25870	46	13	,	,	PUNCT
bibechana-25870	46	14	root	root	NOUN
bibechana-25870	46	15	mean	mean	VERB
bibechana-25870	46	16	square	square	ADJ
bibechana-25870	46	17	deviation	deviation	NOUN
bibechana-25870	46	18	(	(	PUNCT
bibechana-25870	46	19	rmsd	rmsd	NOUN
bibechana-25870	46	20	)	)	PUNCT
bibechana-25870	46	21	,	,	PUNCT
bibechana-25870	46	22	extension	extension	NOUN
bibechana-25870	46	23	or	or	CCONJ
bibechana-25870	46	24	endto	endto	NOUN
bibechana-25870	46	25	-	-	PUNCT
bibechana-25870	46	26	end	end	NOUN
bibechana-25870	46	27	distance	distance	NOUN
bibechana-25870	46	28	(	(	PUNCT
bibechana-25870	46	29	x	x	NOUN
bibechana-25870	46	30	)	)	PUNCT
bibechana-25870	46	31	,	,	PUNCT
bibechana-25870	46	32	forces	force	NOUN
bibechana-25870	46	33	and	and	CCONJ
bibechana-25870	46	34	energies	energy	NOUN
bibechana-25870	46	35	were	be	AUX
bibechana-25870	46	36	noted	note	VERB
bibechana-25870	46	37	down	down	ADP
bibechana-25870	46	38	and	and	CCONJ
bibechana-25870	46	39	the	the	DET
bibechana-25870	46	40	graphical	graphical	ADJ
bibechana-25870	46	41	analysis	analysis	NOUN
bibechana-25870	46	42	was	be	AUX
bibechana-25870	46	43	performed	perform	VERB
bibechana-25870	46	44	with	with	ADP
bibechana-25870	46	45	the	the	DET
bibechana-25870	46	46	plotting	plot	VERB
bibechana-25870	46	47	program	program	NOUN
bibechana-25870	46	48	xmgrace	xmgrace	NOUN
bibechana-25870	46	49	.	.	PUNCT
bibechana-25870	47	1	the	the	DET
bibechana-25870	47	2	smd	smd	PROPN
bibechana-25870	47	3	simulation	simulation	NOUN
bibechana-25870	47	4	was	be	AUX
bibechana-25870	47	5	repeated	repeat	VERB
bibechana-25870	47	6	three	three	NUM
bibechana-25870	47	7	times	time	NOUN
bibechana-25870	47	8	to	to	PART
bibechana-25870	47	9	check	check	VERB
bibechana-25870	47	10	the	the	DET
bibechana-25870	47	11	accuracy	accuracy	NOUN
bibechana-25870	47	12	of	of	ADP
bibechana-25870	47	13	the	the	DET
bibechana-25870	47	14	obtained	obtain	VERB
bibechana-25870	47	15	results	result	NOUN
bibechana-25870	47	16	.	.	PUNCT
bibechana-25870	48	1	3	3	X
bibechana-25870	48	2	.	.	NOUN
bibechana-25870	48	3	results	result	NOUN
bibechana-25870	48	4	and	and	CCONJ
bibechana-25870	48	5	discussion	discussion	NOUN
bibechana-25870	48	6	in	in	ADP
bibechana-25870	48	7	the	the	DET
bibechana-25870	48	8	folding	fold	VERB
bibechana-25870	48	9	state	state	NOUN
bibechana-25870	48	10	or	or	CCONJ
bibechana-25870	48	11	completely	completely	ADV
bibechana-25870	48	12	stable	stable	ADJ
bibechana-25870	48	13	globular	globular	ADJ
bibechana-25870	48	14	form	form	NOUN
bibechana-25870	48	15	,	,	PUNCT
bibechana-25870	48	16	n	n	CCONJ
bibechana-25870	48	17	-	-	PUNCT
bibechana-25870	48	18	c	c	NOUN
bibechana-25870	48	19	termini	termini	NOUN
bibechana-25870	48	20	or	or	CCONJ
bibechana-25870	48	21	end	end	VERB
bibechana-25870	48	22	to	to	PART
bibechana-25870	48	23	end	end	VERB
bibechana-25870	48	24	length	length	NOUN
bibechana-25870	48	25	of	of	ADP
bibechana-25870	48	26	the	the	DET
bibechana-25870	48	27	thrt3	thrt3	PROPN
bibechana-25870	48	28	system	system	NOUN
bibechana-25870	48	29	is	be	AUX
bibechana-25870	48	30	38	38	NUM
bibechana-25870	48	31	å	å	NOUN
bibechana-25870	48	32	.	.	PUNCT
bibechana-25870	49	1	the	the	DET
bibechana-25870	49	2	receptor	receptor	NOUN
bibechana-25870	49	3	protein	protein	NOUN
bibechana-25870	49	4	is	be	AUX
bibechana-25870	49	5	unfolded	unfold	VERB
bibechana-25870	49	6	smoothly	smoothly	ADV
bibechana-25870	49	7	with	with	ADP
bibechana-25870	49	8	simulation	simulation	NOUN
bibechana-25870	49	9	time	time	NOUN
bibechana-25870	49	10	by	by	ADP
bibechana-25870	49	11	breaking	break	VERB
bibechana-25870	49	12	h	h	NOUN
bibechana-25870	49	13	-	-	PUNCT
bibechana-25870	49	14	bonds	bond	NOUN
bibechana-25870	49	15	among	among	ADP
bibechana-25870	49	16	-helices	-helices	PROPN
bibechana-25870	49	17	or	or	CCONJ
bibechana-25870	49	18	-sheets	-sheet	NOUN
bibechana-25870	49	19	during	during	ADP
bibechana-25870	49	20	the	the	DET
bibechana-25870	49	21	constant	constant	ADJ
bibechana-25870	49	22	velocity	velocity	NOUN
bibechana-25870	49	23	(	(	PUNCT
bibechana-25870	49	24	0.1	0.1	NUM
bibechana-25870	49	25	å	å	NOUN
bibechana-25870	49	26	/	/	SYM
bibechana-25870	49	27	ps	ps	NOUN
bibechana-25870	49	28	)	)	PUNCT
bibechana-25870	49	29	pulling	pull	VERB
bibechana-25870	49	30	of	of	ADP
bibechana-25870	49	31	the	the	DET
bibechana-25870	49	32	smd	smd	NOUN
bibechana-25870	49	33	atom	atom	NOUN
bibechana-25870	49	34	.	.	PUNCT
bibechana-25870	50	1	the	the	DET
bibechana-25870	50	2	changing	change	VERB
bibechana-25870	50	3	extension	extension	NOUN
bibechana-25870	50	4	and	and	CCONJ
bibechana-25870	50	5	rg	rg	PROPN
bibechana-25870	50	6	of	of	ADP
bibechana-25870	50	7	thrt3	thrt3	PROPN
bibechana-25870	50	8	over	over	ADP
bibechana-25870	50	9	the	the	DET
bibechana-25870	50	10	course	course	NOUN
bibechana-25870	50	11	of	of	ADP
bibechana-25870	50	12	simulation	simulation	NOUN
bibechana-25870	50	13	are	be	AUX
bibechana-25870	50	14	shown	show	VERB
bibechana-25870	50	15	in	in	ADP
bibechana-25870	50	16	figures	figure	NOUN
bibechana-25870	50	17	1	1	NUM
bibechana-25870	50	18	-	-	SYM
bibechana-25870	50	19	a	a	PRON
bibechana-25870	50	20	&	&	CCONJ
bibechana-25870	50	21	1	1	NUM
bibechana-25870	50	22	-	-	PUNCT
bibechana-25870	50	23	b	b	NOUN
bibechana-25870	50	24	,	,	PUNCT
bibechana-25870	50	25	respectively	respectively	ADV
bibechana-25870	50	26	.	.	PUNCT
bibechana-25870	51	1	the	the	DET
bibechana-25870	51	2	system	system	NOUN
bibechana-25870	51	3	becomes	becomes	AUX
bibechana-25870	51	4	completely	completely	ADV
bibechana-25870	51	5	unfolded	unfold	VERB
bibechana-25870	51	6	after	after	ADP
bibechana-25870	51	7	the	the	DET
bibechana-25870	51	8	simulation	simulation	NOUN
bibechana-25870	51	9	time	time	NOUN
bibechana-25870	51	10	of	of	ADP
bibechana-25870	51	11	8.5	8.5	NUM
bibechana-25870	51	12	ns	ns	NUM
bibechana-25870	51	13	.	.	PUNCT
bibechana-25870	52	1	at	at	ADP
bibechana-25870	52	2	t	t	PROPN
bibechana-25870	52	3	=	=	SYM
bibechana-25870	52	4	8.5	8.5	NUM
bibechana-25870	52	5	ns	ns	NUM
bibechana-25870	52	6	,	,	PUNCT
bibechana-25870	52	7	the	the	DET
bibechana-25870	52	8	end	end	NOUN
bibechana-25870	52	9	-	-	PUNCT
bibechana-25870	52	10	to	to	ADP
bibechana-25870	52	11	-	-	PUNCT
bibechana-25870	52	12	end	end	NOUN
bibechana-25870	52	13	length	length	NOUN
bibechana-25870	52	14	is	be	AUX
bibechana-25870	52	15	876	876	NUM
bibechana-25870	52	16	å	å	PROPN
bibechana-25870	52	17	and	and	CCONJ
bibechana-25870	52	18	rg	rg	PROPN
bibechana-25870	52	19	of	of	ADP
bibechana-25870	52	20	about	about	ADV
bibechana-25870	52	21	258	258	NUM
bibechana-25870	52	22	å	å	NOUN
bibechana-25870	52	23	.	.	PUNCT
bibechana-25870	53	1	the	the	DET
bibechana-25870	53	2	thrt3	thrt3	PROPN
bibechana-25870	53	3	conformations	conformation	NOUN
bibechana-25870	53	4	responsible	responsible	ADJ
bibechana-25870	53	5	for	for	ADP
bibechana-25870	53	6	the	the	DET
bibechana-25870	53	7	peak	peak	NOUN
bibechana-25870	53	8	force	force	NOUN
bibechana-25870	53	9	are	be	AUX
bibechana-25870	53	10	b	b	NOUN
bibechana-25870	53	11	,	,	PUNCT
bibechana-25870	53	12	c	c	PROPN
bibechana-25870	53	13	and	and	CCONJ
bibechana-25870	53	14	d	d	PROPN
bibechana-25870	53	15	as	as	SCONJ
bibechana-25870	53	16	indicated	indicate	VERB
bibechana-25870	53	17	in	in	ADP
bibechana-25870	53	18	force	force	NOUN
bibechana-25870	53	19	vs	vs	ADP
bibechana-25870	53	20	extension	extension	NOUN
bibechana-25870	53	21	graph	graph	NOUN
bibechana-25870	53	22	(	(	PUNCT
bibechana-25870	53	23	figure	figure	NOUN
bibechana-25870	53	24	2	2	NUM
bibechana-25870	53	25	)	)	PUNCT
bibechana-25870	53	26	.	.	PUNCT
bibechana-25870	54	1	the	the	DET
bibechana-25870	54	2	structure	structure	NOUN
bibechana-25870	54	3	a	a	PRON
bibechana-25870	54	4	is	be	AUX
bibechana-25870	54	5	the	the	DET
bibechana-25870	54	6	initial	initial	ADJ
bibechana-25870	54	7	folding	fold	VERB
bibechana-25870	54	8	state	state	NOUN
bibechana-25870	54	9	in	in	ADP
bibechana-25870	54	10	equilibrated	equilibrate	VERB
bibechana-25870	54	11	form	form	NOUN
bibechana-25870	54	12	whereas	whereas	SCONJ
bibechana-25870	54	13	e	e	NOUN
bibechana-25870	54	14	is	be	AUX
bibechana-25870	54	15	the	the	DET
bibechana-25870	54	16	final	final	ADJ
bibechana-25870	54	17	unfolding	unfold	VERB
bibechana-25870	54	18	state	state	NOUN
bibechana-25870	54	19	extended	extend	VERB
bibechana-25870	54	20	to	to	ADP
bibechana-25870	54	21	1023	1023	NUM
bibechana-25870	54	22	å	å	NOUN
bibechana-25870	54	23	.	.	PUNCT
bibechana-25870	55	1	the	the	DET
bibechana-25870	55	2	force	force	NOUN
bibechana-25870	55	3	at	at	ADP
bibechana-25870	55	4	the	the	DET
bibechana-25870	55	5	end	end	NOUN
bibechana-25870	55	6	(	(	PUNCT
bibechana-25870	55	7	t	t	X
bibechana-25870	55	8	>	>	X
bibechana-25870	55	9	8.5	8.5	NUM
bibechana-25870	55	10	ns	ns	NUM
bibechana-25870	55	11	)	)	PUNCT
bibechana-25870	55	12	of	of	ADP
bibechana-25870	55	13	the	the	DET
bibechana-25870	55	14	simulation	simulation	NOUN
bibechana-25870	55	15	increases	increase	VERB
bibechana-25870	55	16	when	when	SCONJ
bibechana-25870	55	17	thrt3	thrt3	PRON
bibechana-25870	55	18	becomes	becomes	AUX
bibechana-25870	55	19	completely	completely	ADV
bibechana-25870	55	20	unfolded	unfold	VERB
bibechana-25870	55	21	due	due	ADJ
bibechana-25870	55	22	to	to	ADP
bibechana-25870	55	23	stretching	stretch	VERB
bibechana-25870	55	24	of	of	ADP
bibechana-25870	55	25	the	the	DET
bibechana-25870	55	26	protein	protein	NOUN
bibechana-25870	55	27	single	single	ADJ
bibechana-25870	55	28	strand	strand	NOUN
bibechana-25870	55	29	.	.	PUNCT
bibechana-25870	56	1	the	the	DET
bibechana-25870	56	2	structures	structure	NOUN
bibechana-25870	56	3	(	(	PUNCT
bibechana-25870	56	4	a	a	PRON
bibechana-25870	56	5	,	,	PUNCT
bibechana-25870	56	6	b	b	NOUN
bibechana-25870	56	7	,	,	PUNCT
bibechana-25870	56	8	c	c	NOUN
bibechana-25870	56	9	,	,	PUNCT
bibechana-25870	56	10	d	d	NOUN
bibechana-25870	56	11	and	and	CCONJ
bibechana-25870	56	12	e	e	X
bibechana-25870	56	13	)	)	PUNCT
bibechana-25870	56	14	formed	form	VERB
bibechana-25870	56	15	by	by	ADP
bibechana-25870	56	16	sequential	sequential	ADJ
bibechana-25870	56	17	unzipping	unzipping	NOUN
bibechana-25870	56	18	of	of	ADP
bibechana-25870	56	19	h	h	NOUN
bibechana-25870	56	20	-	-	PUNCT
bibechana-25870	56	21	bonds	bond	NOUN
bibechana-25870	56	22	are	be	AUX
bibechana-25870	56	23	shown	show	VERB
bibechana-25870	56	24	in	in	ADP
bibechana-25870	56	25	figure	figure	NOUN
bibechana-25870	56	26	3	3	NUM
bibechana-25870	56	27	and	and	CCONJ
bibechana-25870	56	28	the	the	DET
bibechana-25870	56	29	related	relate	VERB
bibechana-25870	56	30	physical	physical	ADJ
bibechana-25870	56	31	parameters	parameter	NOUN
bibechana-25870	56	32	such	such	ADJ
bibechana-25870	56	33	as	as	ADP
bibechana-25870	56	34	time	time	NOUN
bibechana-25870	56	35	,	,	PUNCT
bibechana-25870	56	36	length	length	NOUN
bibechana-25870	56	37	,	,	PUNCT
bibechana-25870	56	38	rg	rg	NOUN
bibechana-25870	56	39	,	,	PUNCT
bibechana-25870	56	40	rmsd	rmsd	VERB
bibechana-25870	56	41	,	,	PUNCT
bibechana-25870	56	42	number	number	NOUN
bibechana-25870	56	43	of	of	ADP
bibechana-25870	56	44	h	h	NOUN
bibechana-25870	56	45	-	-	PUNCT
bibechana-25870	56	46	bonds	bond	NOUN
bibechana-25870	56	47	(	(	PUNCT
bibechana-25870	56	48	at	at	ADP
bibechana-25870	56	49	3	3	NUM
bibechana-25870	56	50	å	å	PROPN
bibechana-25870	56	51	internal	internal	ADJ
bibechana-25870	56	52	distance	distance	NOUN
bibechana-25870	56	53	and	and	CCONJ
bibechana-25870	56	54	20	20	NUM
bibechana-25870	56	55	o	o	NOUN
bibechana-25870	56	56	angle	angle	NOUN
bibechana-25870	56	57	)	)	PUNCT
bibechana-25870	56	58	,	,	PUNCT
bibechana-25870	56	59	force	force	NOUN
bibechana-25870	56	60	,	,	PUNCT
bibechana-25870	56	61	kinetic	kinetic	ADJ
bibechana-25870	56	62	energy	energy	NOUN
bibechana-25870	56	63	(	(	PUNCT
bibechana-25870	56	64	ke	ke	NOUN
bibechana-25870	56	65	)	)	PUNCT
bibechana-25870	56	66	,	,	PUNCT
bibechana-25870	56	67	potential	potential	ADJ
bibechana-25870	56	68	energy	energy	NOUN
bibechana-25870	56	69	(	(	PUNCT
bibechana-25870	56	70	pe	pe	NOUN
bibechana-25870	56	71	)	)	PUNCT
bibechana-25870	56	72	and	and	CCONJ
bibechana-25870	56	73	electrostatic	electrostatic	ADJ
bibechana-25870	56	74	energy	energy	NOUN
bibechana-25870	56	75	are	be	AUX
bibechana-25870	56	76	reported	report	VERB
bibechana-25870	56	77	in	in	ADP
bibechana-25870	56	78	table	table	NOUN
bibechana-25870	56	79	1	1	NUM
bibechana-25870	56	80	.	.	PUNCT
bibechana-25870	57	1	the	the	DET
bibechana-25870	57	2	resistance	resistance	NOUN
bibechana-25870	57	3	of	of	ADP
bibechana-25870	57	4	hbonds	hbond	NOUN
bibechana-25870	57	5	ruptures	rupture	NOUN
bibechana-25870	57	6	simultaneously	simultaneously	ADV
bibechana-25870	57	7	causing	cause	VERB
bibechana-25870	57	8	the	the	DET
bibechana-25870	57	9	structural	structural	ADJ
bibechana-25870	57	10	change	change	NOUN
bibechana-25870	57	11	and	and	CCONJ
bibechana-25870	57	12	rapid	rapid	ADJ
bibechana-25870	57	13	extension	extension	NOUN
bibechana-25870	57	14	of	of	ADP
bibechana-25870	57	15	thrt3	thrt3	PROPN
bibechana-25870	57	16	lbd	lbd	PROPN
bibechana-25870	57	17	.	.	PUNCT
bibechana-25870	58	1	unfolding	unfold	VERB
bibechana-25870	58	2	of	of	ADP
bibechana-25870	58	3	native	native	ADJ
bibechana-25870	58	4	structures	structure	NOUN
bibechana-25870	58	5	needs	need	VERB
bibechana-25870	58	6	the	the	DET
bibechana-25870	58	7	maximum	maximum	ADJ
bibechana-25870	58	8	pulling	pull	VERB
bibechana-25870	58	9	force	force	NOUN
bibechana-25870	58	10	as	as	SCONJ
bibechana-25870	58	11	they	they	PRON
bibechana-25870	58	12	represent	represent	VERB
bibechana-25870	58	13	the	the	DET
bibechana-25870	58	14	bottom	bottom	NOUN
bibechana-25870	58	15	of	of	ADP
bibechana-25870	58	16	the	the	DET
bibechana-25870	58	17	steep	steep	ADJ
bibechana-25870	58	18	free	free	ADJ
bibechana-25870	58	19	energy	energy	NOUN
bibechana-25870	59	1	well	well	NOUN
bibechana-25870	60	1	[	[	X
bibechana-25870	60	2	19	19	NUM
bibechana-25870	60	3	]	]	PUNCT
bibechana-25870	60	4	.	.	PUNCT
bibechana-25870	61	1	(	(	PUNCT
bibechana-25870	61	2	a	a	X
bibechana-25870	61	3	)	)	PUNCT
bibechana-25870	61	4	(	(	PUNCT
bibechana-25870	61	5	b	b	X
bibechana-25870	61	6	)	)	PUNCT
bibechana-25870	61	7	fig	fig	NOUN
bibechana-25870	61	8	.	.	PUNCT
bibechana-25870	62	1	1	1	NUM
bibechana-25870	62	2	:	:	PUNCT
bibechana-25870	62	3	end	end	NOUN
bibechana-25870	62	4	-	-	PUNCT
bibechana-25870	62	5	to	to	ADP
bibechana-25870	62	6	-	-	PUNCT
bibechana-25870	62	7	end	end	NOUN
bibechana-25870	62	8	distance	distance	NOUN
bibechana-25870	62	9	or	or	CCONJ
bibechana-25870	62	10	extension	extension	NOUN
bibechana-25870	62	11	and	and	CCONJ
bibechana-25870	62	12	radius	radius	NOUN
bibechana-25870	62	13	of	of	ADP
bibechana-25870	62	14	gyration	gyration	NOUN
bibechana-25870	62	15	(	(	PUNCT
bibechana-25870	62	16	rg	rg	NOUN
bibechana-25870	62	17	)	)	PUNCT
bibechana-25870	62	18	of	of	ADP
bibechana-25870	62	19	thrt3	thrt3	NOUN
bibechana-25870	62	20	over	over	ADP
bibechana-25870	62	21	the	the	DET
bibechana-25870	62	22	course	course	NOUN
bibechana-25870	62	23	of	of	ADP
bibechana-25870	62	24	smd	smd	PROPN
bibechana-25870	62	25	simulation	simulation	NOUN
bibechana-25870	62	26	.	.	PUNCT
bibechana-25870	63	1	the	the	DET
bibechana-25870	63	2	t3	t3	NOUN
bibechana-25870	63	3	binding	bind	VERB
bibechana-25870	63	4	domain	domain	NOUN
bibechana-25870	63	5	formed	form	VERB
bibechana-25870	63	6	by	by	ADP
bibechana-25870	63	7	-helices	-helices	PROPN
bibechana-25870	63	8	and	and	CCONJ
bibechana-25870	63	9	hairpins	hairpin	NOUN
bibechana-25870	63	10	has	have	AUX
bibechana-25870	63	11	been	be	AUX
bibechana-25870	63	12	verified	verify	VERB
bibechana-25870	63	13	to	to	PART
bibechana-25870	63	14	be	be	AUX
bibechana-25870	63	15	the	the	DET
bibechana-25870	63	16	most	most	ADV
bibechana-25870	63	17	stable	stable	ADJ
bibechana-25870	63	18	region	region	NOUN
bibechana-25870	63	19	,	,	PUNCT
bibechana-25870	63	20	i.e.	i.e.	X
bibechana-25870	63	21	the	the	DET
bibechana-25870	63	22	hormone	hormone	NOUN
bibechana-25870	63	23	binds	bind	VERB
bibechana-25870	63	24	strongly	strongly	ADV
bibechana-25870	63	25	in	in	ADP
bibechana-25870	63	26	the	the	DET
bibechana-25870	63	27	lbd	lbd	NOUN
bibechana-25870	63	28	of	of	ADP
bibechana-25870	63	29	thr-	thr-	PROPN
bibechana-25870	63	30	because	because	SCONJ
bibechana-25870	63	31	this	this	DET
bibechana-25870	63	32	region	region	NOUN
bibechana-25870	63	33	surrounded	surround	VERB
bibechana-25870	63	34	by	by	ADP
bibechana-25870	63	35	a	a	DET
bibechana-25870	63	36	large	large	ADJ
bibechana-25870	63	37	mass	mass	NOUN
bibechana-25870	63	38	of	of	ADP
bibechana-25870	63	39	water	water	NOUN
bibechana-25870	63	40	remains	remain	VERB
bibechana-25870	63	41	almost	almost	ADV
bibechana-25870	63	42	unchanged	unchanged	ADJ
bibechana-25870	63	43	(	(	PUNCT
bibechana-25870	63	44	figure	figure	NOUN
bibechana-25870	63	45	3	3	NUM
bibechana-25870	63	46	-	-	SYM
bibechana-25870	63	47	c	c	NOUN
bibechana-25870	63	48	)	)	PUNCT
bibechana-25870	63	49	even	even	ADV
bibechana-25870	63	50	up	up	ADP
bibechana-25870	63	51	to	to	PART
bibechana-25870	63	52	533	533	NUM
bibechana-25870	63	53	å	å	NOUN
bibechana-25870	63	54	extension	extension	NOUN
bibechana-25870	63	55	and	and	CCONJ
bibechana-25870	63	56	5	5	NUM
bibechana-25870	63	57	ns	ns	NUM
bibechana-25870	63	58	smd	smd	PROPN
bibechana-25870	63	59	simulation	simulation	NOUN
bibechana-25870	63	60	.	.	PUNCT
bibechana-25870	64	1	even	even	ADV
bibechana-25870	64	2	after	after	SCONJ
bibechana-25870	64	3	the	the	DET
bibechana-25870	64	4	t3	t3	NOUN
bibechana-25870	64	5	binding	bind	VERB
bibechana-25870	64	6	pocket	pocket	NOUN
bibechana-25870	64	7	is	be	AUX
bibechana-25870	64	8	completely	completely	ADV
bibechana-25870	64	9	unfolded	unfold	VERB
bibechana-25870	64	10	and	and	CCONJ
bibechana-25870	64	11	the	the	DET
bibechana-25870	64	12	protein	protein	NOUN
bibechana-25870	64	13	rmsd	rmsd	NOUN
bibechana-25870	64	14	is	be	AUX
bibechana-25870	64	15	raised	raise	VERB
bibechana-25870	64	16	up	up	ADP
bibechana-25870	64	17	to	to	ADP
bibechana-25870	64	18	300	300	NUM
bibechana-25870	64	19	å	å	NOUN
bibechana-25870	64	20	(	(	PUNCT
bibechana-25870	64	21	figure	figure	NOUN
bibechana-25870	64	22	4	4	NUM
bibechana-25870	64	23	-	-	PUNCT
bibechana-25870	64	24	a	a	NOUN
bibechana-25870	64	25	)	)	PUNCT
bibechana-25870	64	26	,	,	PUNCT
bibechana-25870	64	27	the	the	DET
bibechana-25870	64	28	position	position	NOUN
bibechana-25870	64	29	of	of	ADP
bibechana-25870	64	30	t3	t3	PROPN
bibechana-25870	64	31	does	do	AUX
bibechana-25870	64	32	not	not	PART
bibechana-25870	64	33	shift	shift	VERB
bibechana-25870	64	34	more	more	ADV
bibechana-25870	64	35	from	from	ADP
bibechana-25870	64	36	its	its	PRON
bibechana-25870	64	37	actual	actual	ADJ
bibechana-25870	64	38	position	position	NOUN
bibechana-25870	64	39	as	as	SCONJ
bibechana-25870	64	40	indicated	indicate	VERB
bibechana-25870	64	41	by	by	ADP
bibechana-25870	64	42	its	its	PRON
bibechana-25870	64	43	rmsd	rmsd	NOUN
bibechana-25870	64	44	(	(	PUNCT
bibechana-25870	64	45	<	<	X
bibechana-25870	64	46	2.5	2.5	NUM
bibechana-25870	64	47	å	å	NOUN
bibechana-25870	64	48	shown	show	VERB
bibechana-25870	64	49	in	in	ADP
bibechana-25870	64	50	figure	figure	NOUN
bibechana-25870	64	51	4tika	4tika	NUM
bibechana-25870	64	52	ram	ram	NOUN
bibechana-25870	64	53	lamichhane	lamichhane	NOUN
bibechana-25870	64	54	,	,	PUNCT
bibechana-25870	64	55	hari	hari	PROPN
bibechana-25870	64	56	prasad	prasad	PROPN
bibechana-25870	64	57	lamichhane	lamichhane	PROPN
bibechana-25870	64	58	/	/	SYM
bibechana-25870	64	59	bibechana	bibechana	PROPN
bibechana-25870	64	60	17	17	NUM
bibechana-25870	64	61	(	(	PUNCT
bibechana-25870	64	62	2020	2020	NUM
bibechana-25870	64	63	)	)	PUNCT
bibechana-25870	64	64	50	50	NUM
bibechana-25870	64	65	-	-	SYM
bibechana-25870	64	66	57	57	NUM
bibechana-25870	64	67	53	53	NUM
bibechana-25870	64	68	b	b	NOUN
bibechana-25870	64	69	)	)	PUNCT
bibechana-25870	64	70	.	.	PUNCT
bibechana-25870	65	1	abrupt	abrupt	ADJ
bibechana-25870	65	2	breaking	breaking	NOUN
bibechana-25870	65	3	of	of	ADP
bibechana-25870	65	4	hydrophobic	hydrophobic	NOUN
bibechana-25870	65	5	contacts	contact	NOUN
bibechana-25870	65	6	between	between	ADP
bibechana-25870	65	7	helices	helix	NOUN
bibechana-25870	65	8	8	8	NUM
bibechana-25870	65	9	and	and	CCONJ
bibechana-25870	65	10	12	12	NUM
bibechana-25870	65	11	is	be	AUX
bibechana-25870	65	12	required	require	VERB
bibechana-25870	65	13	for	for	ADP
bibechana-25870	65	14	the	the	DET
bibechana-25870	65	15	dissociation	dissociation	NOUN
bibechana-25870	65	16	of	of	ADP
bibechana-25870	65	17	t3	t3	PROPN
bibechana-25870	65	18	hormone	hormone	NOUN
bibechana-25870	65	19	from	from	ADP
bibechana-25870	65	20	thr-	thr-	PROPN
bibechana-25870	65	21	lbd	lbd	PROPN
bibechana-25870	65	22	.	.	PUNCT
bibechana-25870	66	1	the	the	DET
bibechana-25870	66	2	ligand	ligand	NOUN
bibechana-25870	66	3	binding	bind	VERB
bibechana-25870	66	4	and	and	CCONJ
bibechana-25870	66	5	dissociation	dissociation	NOUN
bibechana-25870	66	6	pathways	pathway	NOUN
bibechana-25870	66	7	observed	observe	VERB
bibechana-25870	66	8	in	in	ADP
bibechana-25870	66	9	thr	thr	PROPN
bibechana-25870	66	10	-	-	PUNCT
bibechana-25870	66	11	isoforms	isoform	NOUN
bibechana-25870	66	12	by	by	ADP
bibechana-25870	66	13	using	use	VERB
bibechana-25870	66	14	smd	smd	NOUN
bibechana-25870	66	15	simulations	simulation	NOUN
bibechana-25870	66	16	have	have	AUX
bibechana-25870	66	17	been	be	AUX
bibechana-25870	66	18	explained	explain	VERB
bibechana-25870	66	19	in	in	ADP
bibechana-25870	66	20	the	the	DET
bibechana-25870	66	21	previous	previous	ADJ
bibechana-25870	66	22	studies	study	NOUN
bibechana-25870	66	23	[	[	X
bibechana-25870	66	24	10	10	NUM
bibechana-25870	66	25	,	,	PUNCT
bibechana-25870	66	26	20	20	NUM
bibechana-25870	66	27	,	,	PUNCT
bibechana-25870	66	28	21	21	NUM
bibechana-25870	66	29	]	]	PUNCT
bibechana-25870	66	30	.	.	PUNCT
bibechana-25870	67	1	rmsd	rmsd	PROPN
bibechana-25870	67	2	of	of	ADP
bibechana-25870	67	3	t3	t3	PROPN
bibechana-25870	67	4	gets	get	VERB
bibechana-25870	67	5	small	small	ADJ
bibechana-25870	67	6	step	step	NOUN
bibechana-25870	67	7	-	-	PUNCT
bibechana-25870	67	8	up	up	ADP
bibechana-25870	67	9	jump	jump	NOUN
bibechana-25870	67	10	,	,	PUNCT
bibechana-25870	67	11	i.e.	i.e.	X
bibechana-25870	67	12	the	the	DET
bibechana-25870	67	13	ligand	ligand	ADJ
bibechana-25870	67	14	/	/	SYM
bibechana-25870	67	15	hormone	hormone	NOUN
bibechana-25870	67	16	becomes	become	VERB
bibechana-25870	67	17	slightly	slightly	ADV
bibechana-25870	67	18	unstable	unstable	ADJ
bibechana-25870	67	19	in	in	ADP
bibechana-25870	67	20	the	the	DET
bibechana-25870	67	21	unfolding	unfold	VERB
bibechana-25870	67	22	states	state	NOUN
bibechana-25870	67	23	of	of	ADP
bibechana-25870	67	24	thrt3	thrt3	PROPN
bibechana-25870	67	25	responsible	responsible	ADJ
bibechana-25870	67	26	for	for	ADP
bibechana-25870	67	27	the	the	DET
bibechana-25870	67	28	peak	peak	NOUN
bibechana-25870	67	29	force	force	NOUN
bibechana-25870	67	30	generation	generation	NOUN
bibechana-25870	67	31	as	as	SCONJ
bibechana-25870	67	32	shown	show	VERB
bibechana-25870	67	33	in	in	ADP
bibechana-25870	67	34	the	the	DET
bibechana-25870	67	35	figure	figure	NOUN
bibechana-25870	67	36	4	4	NUM
bibechana-25870	67	37	-	-	NOUN
bibechana-25870	67	38	b.	b.	NOUN
bibechana-25870	67	39	along	along	ADP
bibechana-25870	67	40	with	with	ADP
bibechana-25870	67	41	the	the	DET
bibechana-25870	67	42	elongating	elongate	VERB
bibechana-25870	67	43	system	system	NOUN
bibechana-25870	67	44	,	,	PUNCT
bibechana-25870	67	45	h	h	NOUN
bibechana-25870	67	46	-	-	PUNCT
bibechana-25870	67	47	bonds	bond	NOUN
bibechana-25870	67	48	decrease	decrease	NOUN
bibechana-25870	67	49	in	in	ADP
bibechana-25870	67	50	number	number	NOUN
bibechana-25870	67	51	(	(	PUNCT
bibechana-25870	67	52	figure	figure	NOUN
bibechana-25870	67	53	5	5	NUM
bibechana-25870	67	54	-	-	PUNCT
bibechana-25870	67	55	a	a	NOUN
bibechana-25870	67	56	)	)	PUNCT
bibechana-25870	67	57	whereas	whereas	SCONJ
bibechana-25870	67	58	electrostatic	electrostatic	ADJ
bibechana-25870	67	59	energy	energy	NOUN
bibechana-25870	67	60	increases	increase	VERB
bibechana-25870	67	61	up	up	ADP
bibechana-25870	67	62	to	to	ADP
bibechana-25870	67	63	the	the	DET
bibechana-25870	67	64	complete	complete	ADJ
bibechana-25870	67	65	unfolding	unfold	VERB
bibechana-25870	67	66	state	state	NOUN
bibechana-25870	67	67	of	of	ADP
bibechana-25870	67	68	thrt3	thrt3	NOUN
bibechana-25870	67	69	(	(	PUNCT
bibechana-25870	67	70	figure	figure	NOUN
bibechana-25870	67	71	5	5	NUM
bibechana-25870	67	72	-	-	PUNCT
bibechana-25870	67	73	b	b	NOUN
bibechana-25870	67	74	)	)	PUNCT
bibechana-25870	67	75	.	.	PUNCT
bibechana-25870	68	1	at	at	ADP
bibechana-25870	68	2	the	the	DET
bibechana-25870	68	3	time	time	NOUN
bibechana-25870	68	4	of	of	ADP
bibechana-25870	68	5	complete	complete	ADJ
bibechana-25870	68	6	unfolding	unfolding	NOUN
bibechana-25870	68	7	(	(	PUNCT
bibechana-25870	68	8	t	t	NOUN
bibechana-25870	68	9			X
bibechana-25870	68	10	8.5	8.5	NUM
bibechana-25870	68	11	ns	ns	NUM
bibechana-25870	68	12	)	)	PUNCT
bibechana-25870	68	13	,	,	PUNCT
bibechana-25870	68	14	h	h	NOUN
bibechana-25870	68	15	-	-	PUNCT
bibechana-25870	68	16	bonds	bond	NOUN
bibechana-25870	68	17	reduce	reduce	VERB
bibechana-25870	68	18	to	to	ADP
bibechana-25870	68	19	10	10	NUM
bibechana-25870	68	20	and	and	CCONJ
bibechana-25870	68	21	the	the	DET
bibechana-25870	68	22	ranges	range	NOUN
bibechana-25870	68	23	of	of	ADP
bibechana-25870	68	24	ke	ke	NOUN
bibechana-25870	68	25	,	,	PUNCT
bibechana-25870	68	26	pe	pe	PROPN
bibechana-25870	68	27	and	and	CCONJ
bibechana-25870	68	28	electrostatic	electrostatic	ADJ
bibechana-25870	68	29	energy	energy	NOUN
bibechana-25870	68	30	are	be	AUX
bibechana-25870	68	31	13345	13345	NUM
bibechana-25870	68	32	,	,	PUNCT
bibechana-25870	68	33	-5900	-5900	ADJ
bibechana-25870	68	34	and	and	CCONJ
bibechana-25870	68	35	-69000	-69000	PROPN
bibechana-25870	68	36	kcal	kcal	PROPN
bibechana-25870	68	37	/	/	SYM
bibechana-25870	68	38	mol	mol	PROPN
bibechana-25870	68	39	,	,	PUNCT
bibechana-25870	68	40	respectively	respectively	ADV
bibechana-25870	68	41	.	.	PUNCT
bibechana-25870	69	1	the	the	DET
bibechana-25870	69	2	actual	actual	ADJ
bibechana-25870	69	3	data	datum	NOUN
bibechana-25870	69	4	are	be	AUX
bibechana-25870	69	5	reported	report	VERB
bibechana-25870	69	6	in	in	ADP
bibechana-25870	69	7	table	table	NOUN
bibechana-25870	69	8	1	1	NUM
bibechana-25870	69	9	.	.	PUNCT
bibechana-25870	70	1	after	after	ADP
bibechana-25870	70	2	the	the	DET
bibechana-25870	70	3	complete	complete	ADJ
bibechana-25870	70	4	unfolding	unfold	VERB
bibechana-25870	70	5	state	state	NOUN
bibechana-25870	70	6	(	(	PUNCT
bibechana-25870	70	7	t	t	X
bibechana-25870	70	8	>	>	X
bibechana-25870	70	9	8.5	8.5	NUM
bibechana-25870	70	10	ns	ns	NUM
bibechana-25870	70	11	)	)	PUNCT
bibechana-25870	70	12	,	,	PUNCT
bibechana-25870	70	13	h	h	NOUN
bibechana-25870	70	14	-	-	PUNCT
bibechana-25870	70	15	bonds	bond	NOUN
bibechana-25870	70	16	in	in	ADP
bibechana-25870	70	17	a	a	DET
bibechana-25870	70	18	small	small	ADJ
bibechana-25870	70	19	number	number	NOUN
bibechana-25870	70	20	and	and	CCONJ
bibechana-25870	70	21	electrostatic	electrostatic	ADJ
bibechana-25870	70	22	energy	energy	NOUN
bibechana-25870	70	23	both	both	PRON
bibechana-25870	70	24	remain	remain	VERB
bibechana-25870	70	25	almost	almost	ADV
bibechana-25870	70	26	constant	constant	ADJ
bibechana-25870	70	27	as	as	SCONJ
bibechana-25870	70	28	shown	show	VERB
bibechana-25870	70	29	in	in	ADP
bibechana-25870	70	30	figure	figure	NOUN
bibechana-25870	70	31	5	5	NUM
bibechana-25870	70	32	.	.	PUNCT
bibechana-25870	70	33	fig	fig	NOUN
bibechana-25870	70	34	.	.	PUNCT
bibechana-25870	71	1	2	2	NUM
bibechana-25870	71	2	:	:	PUNCT
bibechana-25870	71	3	force	force	NOUN
bibechana-25870	71	4	vs	vs	ADP
bibechana-25870	71	5	extension	extension	NOUN
bibechana-25870	71	6	plot	plot	NOUN
bibechana-25870	71	7	showing	show	VERB
bibechana-25870	71	8	initial	initial	ADJ
bibechana-25870	71	9	folding	fold	VERB
bibechana-25870	71	10	state	state	NOUN
bibechana-25870	71	11	(	(	PUNCT
bibechana-25870	71	12	a	a	NOUN
bibechana-25870	71	13	)	)	PUNCT
bibechana-25870	71	14	,	,	PUNCT
bibechana-25870	71	15	intermediate	intermediate	ADJ
bibechana-25870	71	16	states	state	NOUN
bibechana-25870	71	17	(	(	PUNCT
bibechana-25870	71	18	b	b	NOUN
bibechana-25870	71	19	,	,	PUNCT
bibechana-25870	71	20	c	c	NOUN
bibechana-25870	71	21	)	)	PUNCT
bibechana-25870	71	22	having	have	VERB
bibechana-25870	71	23	greater	great	ADJ
bibechana-25870	71	24	force	force	NOUN
bibechana-25870	71	25	associated	associate	VERB
bibechana-25870	71	26	with	with	ADP
bibechana-25870	71	27	the	the	DET
bibechana-25870	71	28	breaking	breaking	NOUN
bibechana-25870	71	29	of	of	ADP
bibechana-25870	71	30	h	h	NOUN
bibechana-25870	71	31	-	-	PUNCT
bibechana-25870	71	32	bonds	bond	NOUN
bibechana-25870	71	33	among	among	ADP
bibechana-25870	71	34	-helices	-helices	PROPN
bibechana-25870	71	35	or	or	CCONJ
bibechana-25870	71	36	-sheets	-sheet	NOUN
bibechana-25870	71	37	and	and	CCONJ
bibechana-25870	71	38	completely	completely	ADV
bibechana-25870	71	39	unfolding	unfold	VERB
bibechana-25870	71	40	states	state	NOUN
bibechana-25870	71	41	(	(	PUNCT
bibechana-25870	71	42	d	d	NOUN
bibechana-25870	71	43	,	,	PUNCT
bibechana-25870	71	44	e	e	NOUN
bibechana-25870	71	45	)	)	PUNCT
bibechana-25870	71	46	.	.	PUNCT
bibechana-25870	72	1	the	the	DET
bibechana-25870	72	2	force	force	NOUN
bibechana-25870	72	3	at	at	ADP
bibechana-25870	72	4	the	the	DET
bibechana-25870	72	5	end	end	NOUN
bibechana-25870	72	6	(	(	PUNCT
bibechana-25870	72	7	t	t	X
bibechana-25870	72	8	>	>	X
bibechana-25870	72	9	8.5	8.5	NUM
bibechana-25870	72	10	ns	ns	NUM
bibechana-25870	72	11	)	)	PUNCT
bibechana-25870	72	12	increases	increase	NOUN
bibechana-25870	72	13	when	when	SCONJ
bibechana-25870	72	14	thrt3	thrt3	PRON
bibechana-25870	72	15	becomes	becomes	AUX
bibechana-25870	72	16	completely	completely	ADV
bibechana-25870	72	17	unfolded	unfold	VERB
bibechana-25870	72	18	.	.	PUNCT
bibechana-25870	73	1	table	table	NOUN
bibechana-25870	73	2	1	1	NUM
bibechana-25870	73	3	:	:	PUNCT
bibechana-25870	73	4	physical	physical	ADJ
bibechana-25870	73	5	parameters	parameter	NOUN
bibechana-25870	73	6	at	at	ADP
bibechana-25870	73	7	different	different	ADJ
bibechana-25870	73	8	unfolding	unfold	VERB
bibechana-25870	73	9	states	state	NOUN
bibechana-25870	73	10	of	of	ADP
bibechana-25870	73	11	thrt3	thrt3	PRON
bibechana-25870	73	12	protein	protein	NOUN
bibechana-25870	73	13	responsible	responsible	ADJ
bibechana-25870	73	14	for	for	ADP
bibechana-25870	73	15	peak	peak	NOUN
bibechana-25870	73	16	force	force	NOUN
bibechana-25870	73	17	unfolding	unfold	VERB
bibechana-25870	73	18	states	state	NOUN
bibechana-25870	73	19	time	time	NOUN
bibechana-25870	73	20	(	(	PUNCT
bibechana-25870	73	21	ps	ps	NOUN
bibechana-25870	73	22	)	)	PUNCT
bibechana-25870	73	23	end	end	NOUN
bibechana-25870	73	24	-	-	PUNCT
bibechana-25870	73	25	to	to	ADP
bibechana-25870	73	26	-	-	PUNCT
bibechana-25870	73	27	end	end	NOUN
bibechana-25870	73	28	distance	distance	NOUN
bibechana-25870	73	29	(	(	PUNCT
bibechana-25870	73	30	å	å	NOUN
bibechana-25870	73	31	)	)	PUNCT
bibechana-25870	73	32	force	force	NOUN
bibechana-25870	73	33	(	(	PUNCT
bibechana-25870	73	34	kcal	kcal	PROPN
bibechana-25870	73	35	/	/	SYM
bibechana-25870	73	36	mol	mol	PROPN
bibechana-25870	73	37	-	-	PUNCT
bibechana-25870	73	38	å	å	NOUN
bibechana-25870	73	39	)	)	PUNCT
bibechana-25870	73	40	no	no	INTJ
bibechana-25870	73	41	.	.	PUNCT
bibechana-25870	73	42	of	of	ADP
bibechana-25870	73	43	hbonds	hbond	NOUN
bibechana-25870	73	44	rg	rg	INTJ
bibechana-25870	73	45	(	(	PUNCT
bibechana-25870	73	46	å	å	NOUN
bibechana-25870	73	47	)	)	PUNCT
bibechana-25870	73	48	rmsd	rmsd	NOUN
bibechana-25870	73	49	(	(	PUNCT
bibechana-25870	73	50	å	å	NOUN
bibechana-25870	73	51	)	)	PUNCT
bibechana-25870	73	52	ke	ke	NOUN
bibechana-25870	73	53	(	(	PUNCT
bibechana-25870	73	54	kcal	kcal	PROPN
bibechana-25870	73	55	/	/	SYM
bibechana-25870	73	56	mol	mol	NOUN
bibechana-25870	73	57	)	)	PUNCT
bibechana-25870	73	58	pe	pe	PROPN
bibechana-25870	73	59	(	(	PUNCT
bibechana-25870	73	60	kcal	kcal	PROPN
bibechana-25870	73	61	/	/	SYM
bibechana-25870	73	62	mol	mol	NOUN
bibechana-25870	73	63	)	)	PUNCT
bibechana-25870	73	64	elect	elect	NOUN
bibechana-25870	73	65	.	.	PUNCT
bibechana-25870	74	1	energy	energy	NOUN
bibechana-25870	74	2	(	(	PUNCT
bibechana-25870	74	3	kcal	kcal	PROPN
bibechana-25870	74	4	/	/	SYM
bibechana-25870	74	5	mol	mol	PROPN
bibechana-25870	74	6	)	)	PUNCT
bibechana-25870	74	7	a	a	DET
bibechana-25870	74	8	0	0	NUM
bibechana-25870	74	9	38.00	38.00	NUM
bibechana-25870	74	10	0.00	0.00	NUM
bibechana-25870	74	11	60	60	NUM
bibechana-25870	74	12	18.86	18.86	NUM
bibechana-25870	74	13	0.61	0.61	NUM
bibechana-25870	74	14	13809.01	13809.01	NUM
bibechana-25870	74	15	-65680.75	-65680.75	PUNCT
bibechana-25870	75	1	-75115.80	-75115.80	NUM
bibechana-25870	75	2	b	b	NOUN
bibechana-25870	75	3	1673	1673	NUM
bibechana-25870	75	4	203.64	203.64	NUM
bibechana-25870	75	5	15.40	15.40	NUM
bibechana-25870	75	6	54	54	NUM
bibechana-25870	75	7	34.06	34.06	NUM
bibechana-25870	75	8	23.75	23.75	NUM
bibechana-25870	75	9	13832.59	13832.59	NUM
bibechana-25870	75	10	-64576.79	-64576.79	PROPN
bibechana-25870	75	11	-74093.63	-74093.63	PUNCT
bibechana-25870	75	12	c	c	NOUN
bibechana-25870	75	13	4964	4964	NUM
bibechana-25870	76	1	532.87	532.87	NUM
bibechana-25870	76	2	17.17	17.17	NUM
bibechana-25870	76	3	31	31	NUM
bibechana-25870	76	4	125.17	125.17	NUM
bibechana-25870	76	5	121.28	121.28	NUM
bibechana-25870	76	6	13446.59	13446.59	NUM
bibechana-25870	76	7	-61668.09	-61668.09	NOUN
bibechana-25870	76	8	-71620.80	-71620.80	PUNCT
bibechana-25870	76	9	d	d	NOUN
bibechana-25870	76	10	8404	8404	NUM
bibechana-25870	76	11	875.90	875.90	NUM
bibechana-25870	76	12	17.10	17.10	NUM
bibechana-25870	76	13	10	10	NUM
bibechana-25870	76	14	257.22	257.22	NUM
bibechana-25870	76	15	254.02	254.02	NUM
bibechana-25870	76	16	13343.50	13343.50	NUM
bibechana-25870	76	17	-58944.43	-58944.43	NUM
bibechana-25870	76	18	-69681.59	-69681.59	NUM
bibechana-25870	76	19	e	e	NOUN
bibechana-25870	76	20	10000	10000	NUM
bibechana-25870	76	21	1023.29	1023.29	NUM
bibechana-25870	76	22	98.21	98.21	NUM
bibechana-25870	76	23	9	9	NUM
bibechana-25870	76	24	300.66	300.66	NUM
bibechana-25870	76	25	297.56	297.56	NUM
bibechana-25870	76	26	13273.46	13273.46	NUM
bibechana-25870	76	27	-50967.98	-50967.98	NUM
bibechana-25870	76	28	-69695.32	-69695.32	NUM
bibechana-25870	76	29	c	c	NOUN
bibechana-25870	76	30	d	d	X
bibechana-25870	76	31	tika	tika	X
bibechana-25870	76	32	ram	ram	NOUN
bibechana-25870	76	33	lamichhane	lamichhane	NOUN
bibechana-25870	76	34	,	,	PUNCT
bibechana-25870	76	35	hari	hari	PROPN
bibechana-25870	76	36	prasad	prasad	PROPN
bibechana-25870	76	37	lamichhane	lamichhane	PROPN
bibechana-25870	76	38	/	/	SYM
bibechana-25870	76	39	bibechana	bibechana	PROPN
bibechana-25870	76	40	17	17	NUM
bibechana-25870	76	41	(	(	PUNCT
bibechana-25870	76	42	2020	2020	NUM
bibechana-25870	76	43	)	)	PUNCT
bibechana-25870	76	44	50	50	NUM
bibechana-25870	76	45	-	-	SYM
bibechana-25870	76	46	57	57	NUM
bibechana-25870	76	47	54	54	NUM
bibechana-25870	76	48	(	(	PUNCT
bibechana-25870	76	49	a	a	NOUN
bibechana-25870	76	50	)	)	PUNCT
bibechana-25870	76	51	t	t	NOUN
bibechana-25870	76	52	=	=	SYM
bibechana-25870	76	53	0	0	NUM
bibechana-25870	76	54	ps	ps	NOUN
bibechana-25870	76	55	,	,	PUNCT
bibechana-25870	76	56	x	x	X
bibechana-25870	76	57	=	=	SYM
bibechana-25870	76	58	38.00	38.00	NUM
bibechana-25870	76	59	å	å	X
bibechana-25870	76	60	(	(	PUNCT
bibechana-25870	76	61	c	c	NOUN
bibechana-25870	76	62	)	)	PUNCT
bibechana-25870	76	63	t	t	NOUN
bibechana-25870	76	64	=	=	SYM
bibechana-25870	76	65	4964	4964	NUM
bibechana-25870	76	66	ps	ps	NOUN
bibechana-25870	76	67	,	,	PUNCT
bibechana-25870	76	68	x	x	X
bibechana-25870	76	69	=	=	PUNCT
bibechana-25870	76	70	532.87	532.87	NUM
bibechana-25870	76	71	å	å	X
bibechana-25870	76	72	(	(	PUNCT
bibechana-25870	76	73	d	d	NOUN
bibechana-25870	76	74	)	)	PUNCT
bibechana-25870	76	75	t	t	NOUN
bibechana-25870	76	76	=	=	SYM
bibechana-25870	76	77	8404	8404	NUM
bibechana-25870	76	78	ps	ps	NOUN
bibechana-25870	76	79	,	,	PUNCT
bibechana-25870	76	80	x	x	X
bibechana-25870	76	81	=	=	PUNCT
bibechana-25870	76	82	875.90	875.90	NUM
bibechana-25870	76	83	å	å	X
bibechana-25870	76	84	(	(	PUNCT
bibechana-25870	76	85	e	e	NOUN
bibechana-25870	76	86	)	)	PUNCT
bibechana-25870	76	87	t	t	NOUN
bibechana-25870	76	88	=	=	SYM
bibechana-25870	76	89	10000ps	10000ps	PROPN
bibechana-25870	76	90	,	,	PUNCT
bibechana-25870	76	91	x	x	PUNCT
bibechana-25870	76	92	=	=	SYM
bibechana-25870	76	93	1023.29	1023.29	NUM
bibechana-25870	76	94	å	å	PROPN
bibechana-25870	76	95	(	(	PUNCT
bibechana-25870	76	96	b	b	NOUN
bibechana-25870	76	97	)	)	PUNCT
bibechana-25870	76	98	t	t	NOUN
bibechana-25870	76	99	=	=	SYM
bibechana-25870	76	100	1673	1673	NUM
bibechana-25870	76	101	ps	ps	NOUN
bibechana-25870	76	102	,	,	PUNCT
bibechana-25870	76	103	x	x	X
bibechana-25870	76	104	=	=	PUNCT
bibechana-25870	76	105	203.64	203.64	NUM
bibechana-25870	76	106	å	å	PROPN
bibechana-25870	76	107	fig	fig	NOUN
bibechana-25870	76	108	.	.	PUNCT
bibechana-25870	77	1	3	3	NUM
bibechana-25870	77	2	:	:	PUNCT
bibechana-25870	77	3	different	different	ADJ
bibechana-25870	77	4	unfolding	unfold	VERB
bibechana-25870	77	5	states	state	NOUN
bibechana-25870	77	6	responsible	responsible	ADJ
bibechana-25870	77	7	for	for	ADP
bibechana-25870	77	8	peak	peak	NOUN
bibechana-25870	77	9	force	force	NOUN
bibechana-25870	77	10	provided	provide	VERB
bibechana-25870	77	11	with	with	ADP
bibechana-25870	77	12	the	the	DET
bibechana-25870	77	13	simulation	simulation	NOUN
bibechana-25870	77	14	time	time	NOUN
bibechana-25870	77	15	(	(	PUNCT
bibechana-25870	77	16	t	t	NOUN
bibechana-25870	77	17	)	)	PUNCT
bibechana-25870	77	18	and	and	CCONJ
bibechana-25870	77	19	end	end	NOUN
bibechana-25870	77	20	-	-	PUNCT
bibechana-25870	77	21	to	to	ADP
bibechana-25870	77	22	-	-	PUNCT
bibechana-25870	77	23	end	end	NOUN
bibechana-25870	77	24	distance	distance	NOUN
bibechana-25870	77	25	(	(	PUNCT
bibechana-25870	77	26	x	x	X
bibechana-25870	77	27	)	)	PUNCT
bibechana-25870	77	28	during	during	ADP
bibechana-25870	77	29	the	the	DET
bibechana-25870	77	30	constant	constant	ADJ
bibechana-25870	77	31	velocity	velocity	NOUN
bibechana-25870	77	32	(	(	PUNCT
bibechana-25870	77	33	0.1	0.1	NUM
bibechana-25870	77	34	å	å	NOUN
bibechana-25870	77	35	/	/	SYM
bibechana-25870	77	36	ps	ps	NOUN
bibechana-25870	77	37	)	)	PUNCT
bibechana-25870	77	38	stretching	stretching	NOUN
bibechana-25870	77	39	of	of	ADP
bibechana-25870	77	40	thrt3	thrt3	PROPN
bibechana-25870	77	41	.	.	PUNCT
bibechana-25870	78	1	fig	fig	NOUN
bibechana-25870	78	2	.	.	PUNCT
bibechana-25870	79	1	4	4	NUM
bibechana-25870	79	2	:	:	PUNCT
bibechana-25870	79	3	root	root	NOUN
bibechana-25870	79	4	mean	mean	ADJ
bibechana-25870	79	5	square	square	ADJ
bibechana-25870	79	6	deviation	deviation	NOUN
bibechana-25870	79	7	(	(	PUNCT
bibechana-25870	79	8	rmsd	rmsd	NOUN
bibechana-25870	79	9	)	)	PUNCT
bibechana-25870	79	10	of	of	ADP
bibechana-25870	79	11	(	(	PUNCT
bibechana-25870	79	12	a	a	X
bibechana-25870	79	13	)	)	PUNCT
bibechana-25870	79	14	receptor	receptor	NOUN
bibechana-25870	79	15	protein	protein	NOUN
bibechana-25870	79	16	and	and	CCONJ
bibechana-25870	79	17	(	(	PUNCT
bibechana-25870	79	18	b	b	NOUN
bibechana-25870	79	19	)	)	PUNCT
bibechana-25870	79	20	t3	t3	NOUN
bibechana-25870	79	21	-	-	PUNCT
bibechana-25870	79	22	hormone	hormone	NOUN
bibechana-25870	79	23	during	during	ADP
bibechana-25870	79	24	unfolding	unfolding	NOUN
bibechana-25870	79	25	of	of	ADP
bibechana-25870	79	26	thrt3	thrt3	PROPN
bibechana-25870	79	27	.	.	PUNCT
bibechana-25870	80	1	tika	tika	PROPN
bibechana-25870	80	2	ram	ram	PROPN
bibechana-25870	80	3	lamichhane	lamichhane	NOUN
bibechana-25870	80	4	,	,	PUNCT
bibechana-25870	80	5	hari	hari	PROPN
bibechana-25870	80	6	prasad	prasad	PROPN
bibechana-25870	80	7	lamichhane	lamichhane	PROPN
bibechana-25870	80	8	/	/	SYM
bibechana-25870	80	9	bibechana	bibechana	PROPN
bibechana-25870	80	10	17	17	NUM
bibechana-25870	80	11	(	(	PUNCT
bibechana-25870	80	12	2020	2020	NUM
bibechana-25870	80	13	)	)	PUNCT
bibechana-25870	80	14	50	50	NUM
bibechana-25870	80	15	-	-	SYM
bibechana-25870	80	16	57	57	NUM
bibechana-25870	80	17	55	55	NUM
bibechana-25870	80	18	fig	fig	NOUN
bibechana-25870	80	19	.	.	PUNCT
bibechana-25870	81	1	5	5	NUM
bibechana-25870	81	2	:	:	PUNCT
bibechana-25870	81	3	variation	variation	NOUN
bibechana-25870	81	4	of	of	ADP
bibechana-25870	81	5	(	(	PUNCT
bibechana-25870	81	6	a	a	PRON
bibechana-25870	81	7	)	)	PUNCT
bibechana-25870	81	8	h	h	NOUN
bibechana-25870	81	9	-	-	PUNCT
bibechana-25870	81	10	bonds	bond	NOUN
bibechana-25870	81	11	and	and	CCONJ
bibechana-25870	81	12	(	(	PUNCT
bibechana-25870	81	13	b	b	NOUN
bibechana-25870	81	14	)	)	PUNCT
bibechana-25870	81	15	electrostatic	electrostatic	ADJ
bibechana-25870	81	16	energy	energy	NOUN
bibechana-25870	81	17	over	over	ADP
bibechana-25870	81	18	the	the	DET
bibechana-25870	81	19	course	course	NOUN
bibechana-25870	81	20	of	of	ADP
bibechana-25870	81	21	10	10	NUM
bibechana-25870	81	22	ns	ns	NUM
bibechana-25870	81	23	smd	smd	NOUN
bibechana-25870	81	24	simulation	simulation	NOUN
bibechana-25870	81	25	at	at	ADP
bibechana-25870	81	26	constant	constant	ADJ
bibechana-25870	81	27	velocity	velocity	NOUN
bibechana-25870	81	28	(	(	PUNCT
bibechana-25870	81	29	0.1	0.1	NUM
bibechana-25870	81	30	å	å	NOUN
bibechana-25870	81	31	/	/	SYM
bibechana-25870	81	32	ps	ps	NOUN
bibechana-25870	81	33	)	)	PUNCT
bibechana-25870	81	34	pulling	pull	VERB
bibechana-25870	81	35	of	of	ADP
bibechana-25870	81	36	thrt3	thrt3	PRON
bibechana-25870	81	37	.	.	PUNCT
bibechana-25870	82	1	fig	fig	NOUN
bibechana-25870	82	2	.	.	PUNCT
bibechana-25870	83	1	6	6	NUM
bibechana-25870	83	2	:	:	PUNCT
bibechana-25870	83	3	energy	energy	NOUN
bibechana-25870	83	4	profile	profile	NOUN
bibechana-25870	83	5	diagram	diagram	NOUN
bibechana-25870	83	6	during	during	ADP
bibechana-25870	83	7	unfolding	unfolding	NOUN
bibechana-25870	83	8	of	of	ADP
bibechana-25870	83	9	thrt3	thrt3	NOUN
bibechana-25870	83	10	by	by	ADP
bibechana-25870	83	11	smd	smd	NOUN
bibechana-25870	83	12	at	at	ADP
bibechana-25870	83	13	constant	constant	ADJ
bibechana-25870	83	14	velocity	velocity	NOUN
bibechana-25870	83	15	(	(	PUNCT
bibechana-25870	83	16	0.1	0.1	NUM
bibechana-25870	83	17	å	å	NOUN
bibechana-25870	83	18	/	/	SYM
bibechana-25870	83	19	ps	ps	NOUN
bibechana-25870	83	20	)	)	PUNCT
bibechana-25870	83	21	pulling	pull	VERB
bibechana-25870	83	22	.	.	PUNCT
bibechana-25870	84	1	(	(	PUNCT
bibechana-25870	84	2	a	a	X
bibechana-25870	84	3	)	)	PUNCT
bibechana-25870	84	4	(	(	PUNCT
bibechana-25870	84	5	b	b	X
bibechana-25870	84	6	)	)	PUNCT
bibechana-25870	84	7	fig	fig	NOUN
bibechana-25870	84	8	.	.	PUNCT
bibechana-25870	85	1	7	7	NUM
bibechana-25870	85	2	:	:	PUNCT
bibechana-25870	85	3	variation	variation	NOUN
bibechana-25870	85	4	of	of	ADP
bibechana-25870	85	5	(	(	PUNCT
bibechana-25870	85	6	a	a	PRON
bibechana-25870	85	7	)	)	PUNCT
bibechana-25870	85	8	kinetic	kinetic	NOUN
bibechana-25870	85	9	and	and	CCONJ
bibechana-25870	85	10	(	(	PUNCT
bibechana-25870	85	11	b	b	NOUN
bibechana-25870	85	12	)	)	PUNCT
bibechana-25870	85	13	internal	internal	ADJ
bibechana-25870	85	14	potential	potential	ADJ
bibechana-25870	85	15	energies	energy	NOUN
bibechana-25870	85	16	over	over	ADP
bibechana-25870	85	17	the	the	DET
bibechana-25870	85	18	course	course	NOUN
bibechana-25870	85	19	of	of	ADP
bibechana-25870	85	20	10	10	NUM
bibechana-25870	85	21	ns	ns	NUM
bibechana-25870	85	22	smd	smd	NOUN
bibechana-25870	85	23	simulation	simulation	NOUN
bibechana-25870	85	24	at	at	ADP
bibechana-25870	85	25	constant	constant	ADJ
bibechana-25870	85	26	velocity	velocity	NOUN
bibechana-25870	85	27	(	(	PUNCT
bibechana-25870	85	28	0.1	0.1	NUM
bibechana-25870	85	29	å	å	NOUN
bibechana-25870	85	30	/	/	SYM
bibechana-25870	85	31	ps	ps	NOUN
bibechana-25870	85	32	)	)	PUNCT
bibechana-25870	85	33	pulling	pull	VERB
bibechana-25870	85	34	of	of	ADP
bibechana-25870	85	35	energy	energy	NOUN
bibechana-25870	85	36	.	.	PUNCT
bibechana-25870	86	1	tika	tika	PROPN
bibechana-25870	86	2	ram	ram	PROPN
bibechana-25870	86	3	lamichhane	lamichhane	NOUN
bibechana-25870	86	4	,	,	PUNCT
bibechana-25870	86	5	hari	hari	PROPN
bibechana-25870	86	6	prasad	prasad	PROPN
bibechana-25870	86	7	lamichhane	lamichhane	PROPN
bibechana-25870	86	8	/	/	SYM
bibechana-25870	86	9	bibechana	bibechana	PROPN
bibechana-25870	86	10	17	17	NUM
bibechana-25870	86	11	(	(	PUNCT
bibechana-25870	86	12	2020	2020	NUM
bibechana-25870	86	13	)	)	PUNCT
bibechana-25870	86	14	50	50	NUM
bibechana-25870	86	15	-	-	SYM
bibechana-25870	86	16	57	57	NUM
bibechana-25870	86	17	56	56	NUM
bibechana-25870	86	18	the	the	DET
bibechana-25870	86	19	linard	linard	PROPN
bibechana-25870	86	20	jones	jones	PROPN
bibechana-25870	86	21	potential	potential	NOUN
bibechana-25870	86	22	is	be	AUX
bibechana-25870	86	23	getting	getting	AUX
bibechana-25870	86	24	raised	raise	VERB
bibechana-25870	86	25	linearly	linearly	ADV
bibechana-25870	86	26	with	with	ADP
bibechana-25870	86	27	small	small	ADJ
bibechana-25870	86	28	slope	slope	NOUN
bibechana-25870	86	29	and	and	CCONJ
bibechana-25870	86	30	the	the	DET
bibechana-25870	86	31	energy	energy	NOUN
bibechana-25870	86	32	terms	term	NOUN
bibechana-25870	86	33	:	:	PUNCT
bibechana-25870	86	34	dihedral	dihedral	ADJ
bibechana-25870	86	35	and	and	CCONJ
bibechana-25870	86	36	improper	improper	ADJ
bibechana-25870	86	37	remain	remain	VERB
bibechana-25870	86	38	almost	almost	ADV
bibechana-25870	86	39	constant	constant	ADJ
bibechana-25870	86	40	throughout	throughout	ADP
bibechana-25870	86	41	the	the	DET
bibechana-25870	86	42	smd	smd	NOUN
bibechana-25870	86	43	simulation	simulation	NOUN
bibechana-25870	86	44	.	.	PUNCT
bibechana-25870	87	1	bond	bond	NOUN
bibechana-25870	87	2	-	-	PUNCT
bibechana-25870	87	3	angle	angle	NOUN
bibechana-25870	87	4	and	and	CCONJ
bibechana-25870	87	5	bond	bond	NOUN
bibechana-25870	87	6	-	-	PUNCT
bibechana-25870	87	7	length	length	NOUN
bibechana-25870	87	8	energies	energy	NOUN
bibechana-25870	87	9	are	be	AUX
bibechana-25870	87	10	almost	almost	ADV
bibechana-25870	87	11	constant	constant	ADJ
bibechana-25870	87	12	before	before	ADP
bibechana-25870	87	13	8.5	8.5	NUM
bibechana-25870	87	14	ns	ns	NUM
bibechana-25870	87	15	and	and	CCONJ
bibechana-25870	87	16	they	they	PRON
bibechana-25870	87	17	rise	rise	VERB
bibechana-25870	87	18	up	up	ADP
bibechana-25870	87	19	steeply	steeply	ADV
bibechana-25870	87	20	after	after	ADP
bibechana-25870	87	21	8.5	8.5	NUM
bibechana-25870	87	22	ns	ns	NUM
bibechana-25870	87	23	when	when	SCONJ
bibechana-25870	87	24	thrt3	thrt3	PRON
bibechana-25870	87	25	is	be	AUX
bibechana-25870	87	26	completely	completely	ADV
bibechana-25870	87	27	unfolded	unfold	VERB
bibechana-25870	87	28	as	as	SCONJ
bibechana-25870	87	29	shown	show	VERB
bibechana-25870	87	30	in	in	ADP
bibechana-25870	87	31	figure	figure	NOUN
bibechana-25870	87	32	6	6	NUM
bibechana-25870	87	33	.	.	PUNCT
bibechana-25870	87	34	figures	figure	NOUN
bibechana-25870	87	35	7	7	NUM
bibechana-25870	87	36	-	-	SYM
bibechana-25870	87	37	a	a	PRON
bibechana-25870	87	38	&	&	CCONJ
bibechana-25870	87	39	7	7	NUM
bibechana-25870	87	40	-	-	PUNCT
bibechana-25870	87	41	b	b	NOUN
bibechana-25870	87	42	show	show	NOUN
bibechana-25870	87	43	that	that	SCONJ
bibechana-25870	87	44	ke	ke	NOUN
bibechana-25870	87	45	decreases	decrease	VERB
bibechana-25870	87	46	slowly	slowly	ADV
bibechana-25870	87	47	and	and	CCONJ
bibechana-25870	87	48	linearly	linearly	ADV
bibechana-25870	87	49	throughout	throughout	ADP
bibechana-25870	87	50	the	the	DET
bibechana-25870	87	51	simulation	simulation	NOUN
bibechana-25870	87	52	,	,	PUNCT
bibechana-25870	87	53	and	and	CCONJ
bibechana-25870	87	54	conversely	conversely	ADV
bibechana-25870	87	55	,	,	PUNCT
bibechana-25870	87	56	pe	pe	PROPN
bibechana-25870	87	57	increases	increase	VERB
bibechana-25870	87	58	slightly	slightly	ADV
bibechana-25870	87	59	up	up	ADP
bibechana-25870	87	60	to	to	ADP
bibechana-25870	87	61	the	the	DET
bibechana-25870	87	62	state	state	NOUN
bibechana-25870	87	63	of	of	ADP
bibechana-25870	87	64	complete	complete	ADJ
bibechana-25870	87	65	unfolding	unfolding	NOUN
bibechana-25870	87	66	of	of	ADP
bibechana-25870	87	67	thrt3	thrt3	PROPN
bibechana-25870	87	68	.	.	PUNCT
bibechana-25870	88	1	when	when	SCONJ
bibechana-25870	88	2	the	the	DET
bibechana-25870	88	3	system	system	NOUN
bibechana-25870	88	4	is	be	AUX
bibechana-25870	88	5	completely	completely	ADV
bibechana-25870	88	6	unfolded	unfold	VERB
bibechana-25870	88	7	(	(	PUNCT
bibechana-25870	88	8	t	t	X
bibechana-25870	88	9	>	>	X
bibechana-25870	88	10	8.5	8.5	NUM
bibechana-25870	88	11	ns	ns	NUM
bibechana-25870	88	12	)	)	PUNCT
bibechana-25870	88	13	,	,	PUNCT
bibechana-25870	88	14	pe	pe	PROPN
bibechana-25870	88	15	increases	increase	VERB
bibechana-25870	88	16	steeply	steeply	ADV
bibechana-25870	88	17	.	.	PUNCT
bibechana-25870	89	1	the	the	DET
bibechana-25870	89	2	cause	cause	NOUN
bibechana-25870	89	3	behind	behind	ADP
bibechana-25870	89	4	the	the	DET
bibechana-25870	89	5	steeply	steeply	NOUN
bibechana-25870	89	6	changed	change	VERB
bibechana-25870	89	7	pe	pe	INTJ
bibechana-25870	89	8	is	be	AUX
bibechana-25870	89	9	the	the	DET
bibechana-25870	89	10	fast	fast	ADV
bibechana-25870	89	11	increasing	increase	VERB
bibechana-25870	89	12	force	force	NOUN
bibechana-25870	89	13	generated	generate	VERB
bibechana-25870	89	14	after	after	ADP
bibechana-25870	89	15	unwinding	unwind	VERB
bibechana-25870	89	16	the	the	DET
bibechana-25870	89	17	molecular	molecular	ADJ
bibechana-25870	89	18	system	system	NOUN
bibechana-25870	89	19	.	.	PUNCT
bibechana-25870	90	1	the	the	DET
bibechana-25870	90	2	load	load	NOUN
bibechana-25870	90	3	bearing	bear	VERB
bibechana-25870	90	4	strands	strand	NOUN
bibechana-25870	90	5	are	be	AUX
bibechana-25870	90	6	shielded	shield	VERB
bibechana-25870	90	7	by	by	ADP
bibechana-25870	90	8	water	water	NOUN
bibechana-25870	90	9	and	and	CCONJ
bibechana-25870	90	10	it	it	PRON
bibechana-25870	90	11	interacts	interact	VERB
bibechana-25870	90	12	with	with	ADP
bibechana-25870	90	13	bond	bond	NOUN
bibechana-25870	90	14	-	-	PUNCT
bibechana-25870	90	15	breaking	break	VERB
bibechana-25870	90	16	events	event	NOUN
bibechana-25870	90	17	between	between	ADP
bibechana-25870	90	18	such	such	ADJ
bibechana-25870	90	19	strands	strand	NOUN
bibechana-25870	90	20	[	[	X
bibechana-25870	90	21	9	9	NUM
bibechana-25870	90	22	]	]	PUNCT
bibechana-25870	90	23	.	.	PUNCT
bibechana-25870	91	1	even	even	ADV
bibechana-25870	91	2	if	if	SCONJ
bibechana-25870	91	3	the	the	DET
bibechana-25870	91	4	strand	strand	NOUN
bibechana-25870	91	5	is	be	AUX
bibechana-25870	91	6	fully	fully	ADV
bibechana-25870	91	7	dissociated	dissociate	VERB
bibechana-25870	91	8	,	,	PUNCT
bibechana-25870	91	9	water	water	NOUN
bibechana-25870	91	10	makes	make	VERB
bibechana-25870	91	11	h	h	NOUN
bibechana-25870	91	12	-	-	PUNCT
bibechana-25870	91	13	bonding	bonding	NOUN
bibechana-25870	91	14	to	to	ADP
bibechana-25870	91	15	the	the	DET
bibechana-25870	91	16	exposed	expose	VERB
bibechana-25870	91	17	sites	site	NOUN
bibechana-25870	91	18	as	as	ADP
bibechana-25870	91	19	in	in	ADP
bibechana-25870	91	20	figure	figure	NOUN
bibechana-25870	91	21	3	3	NUM
bibechana-25870	91	22	.	.	PUNCT
bibechana-25870	92	1	the	the	DET
bibechana-25870	92	2	hydrophobic	hydrophobic	NOUN
bibechana-25870	92	3	lbd	lbd	NOUN
bibechana-25870	92	4	of	of	ADP
bibechana-25870	92	5	thr-	thr-	PROPN
bibechana-25870	92	6	with	with	ADP
bibechana-25870	92	7	load	load	NOUN
bibechana-25870	92	8	bearing	bear	VERB
bibechana-25870	92	9	h	h	NOUN
bibechana-25870	92	10	-	-	PUNCT
bibechana-25870	92	11	bonds	bond	NOUN
bibechana-25870	92	12	is	be	AUX
bibechana-25870	92	13	protected	protect	VERB
bibechana-25870	92	14	from	from	ADP
bibechana-25870	92	15	water	water	NOUN
bibechana-25870	92	16	attack	attack	NOUN
bibechana-25870	92	17	so	so	SCONJ
bibechana-25870	92	18	that	that	SCONJ
bibechana-25870	92	19	t3	t3	PROPN
bibechana-25870	92	20	is	be	AUX
bibechana-25870	92	21	not	not	PART
bibechana-25870	92	22	dragged	drag	VERB
bibechana-25870	92	23	away	away	ADV
bibechana-25870	92	24	from	from	ADP
bibechana-25870	92	25	its	its	PRON
bibechana-25870	92	26	pocket	pocket	NOUN
bibechana-25870	92	27	position	position	NOUN
bibechana-25870	92	28	even	even	ADV
bibechana-25870	92	29	if	if	SCONJ
bibechana-25870	92	30	the	the	DET
bibechana-25870	92	31	system	system	NOUN
bibechana-25870	92	32	is	be	AUX
bibechana-25870	92	33	completely	completely	ADV
bibechana-25870	92	34	unfolded	unfold	VERB
bibechana-25870	92	35	.	.	PUNCT
bibechana-25870	93	1	in	in	ADP
bibechana-25870	93	2	order	order	NOUN
bibechana-25870	93	3	to	to	PART
bibechana-25870	93	4	employ	employ	VERB
bibechana-25870	93	5	the	the	DET
bibechana-25870	93	6	reversible	reversible	ADJ
bibechana-25870	93	7	work	work	NOUN
bibechana-25870	93	8	comparable	comparable	ADJ
bibechana-25870	93	9	to	to	ADP
bibechana-25870	93	10	afm	afm	PROPN
bibechana-25870	93	11	experiments	experiment	NOUN
bibechana-25870	93	12	,	,	PUNCT
bibechana-25870	93	13	very	very	ADV
bibechana-25870	93	14	low	low	ADJ
bibechana-25870	93	15	speed	speed	NOUN
bibechana-25870	93	16	pulling	pull	VERB
bibechana-25870	93	17	is	be	AUX
bibechana-25870	93	18	to	to	PART
bibechana-25870	93	19	be	be	AUX
bibechana-25870	93	20	implemented	implement	VERB
bibechana-25870	93	21	while	while	SCONJ
bibechana-25870	93	22	unwinding	unwind	VERB
bibechana-25870	93	23	the	the	DET
bibechana-25870	93	24	molecular	molecular	ADJ
bibechana-25870	93	25	system	system	NOUN
bibechana-25870	93	26	which	which	PRON
bibechana-25870	93	27	is	be	AUX
bibechana-25870	93	28	practically	practically	ADV
bibechana-25870	93	29	difficult	difficult	ADJ
bibechana-25870	93	30	due	due	ADJ
bibechana-25870	93	31	to	to	ADP
bibechana-25870	93	32	computational	computational	ADJ
bibechana-25870	93	33	limits	limit	NOUN
bibechana-25870	93	34	.	.	PUNCT
bibechana-25870	94	1	however	however	ADV
bibechana-25870	94	2	,	,	PUNCT
bibechana-25870	94	3	higher	high	ADJ
bibechana-25870	94	4	pulling	pull	VERB
bibechana-25870	94	5	velocities	velocity	NOUN
bibechana-25870	94	6	do	do	AUX
bibechana-25870	94	7	not	not	PART
bibechana-25870	94	8	influence	influence	VERB
bibechana-25870	94	9	the	the	DET
bibechana-25870	94	10	reliability	reliability	NOUN
bibechana-25870	94	11	of	of	ADP
bibechana-25870	94	12	the	the	DET
bibechana-25870	94	13	smd	smd	NOUN
bibechana-25870	94	14	results	result	NOUN
bibechana-25870	94	15	[	[	X
bibechana-25870	94	16	22	22	NUM
bibechana-25870	94	17	]	]	PUNCT
bibechana-25870	94	18	.	.	PUNCT
bibechana-25870	95	1	continuous	continuous	ADJ
bibechana-25870	95	2	breaking	breaking	NOUN
bibechana-25870	95	3	of	of	ADP
bibechana-25870	95	4	h	h	NOUN
bibechana-25870	95	5	-	-	PUNCT
bibechana-25870	95	6	bonds	bond	NOUN
bibechana-25870	95	7	up	up	ADP
bibechana-25870	95	8	to	to	ADP
bibechana-25870	95	9	the	the	DET
bibechana-25870	95	10	complete	complete	ADJ
bibechana-25870	95	11	unfolding	unfolding	NOUN
bibechana-25870	95	12	of	of	ADP
bibechana-25870	95	13	thrt3	thrt3	NOUN
bibechana-25870	95	14	(	(	PUNCT
bibechana-25870	95	15	figure	figure	NOUN
bibechana-25870	95	16	5	5	NUM
bibechana-25870	95	17	-	-	PUNCT
bibechana-25870	95	18	a	a	NOUN
bibechana-25870	95	19	)	)	PUNCT
bibechana-25870	95	20	and	and	CCONJ
bibechana-25870	95	21	force	force	NOUN
bibechana-25870	95	22	vs	vs	ADP
bibechana-25870	95	23	extension	extension	NOUN
bibechana-25870	95	24	graph	graph	NOUN
bibechana-25870	95	25	(	(	PUNCT
bibechana-25870	95	26	figure	figure	NOUN
bibechana-25870	95	27	2	2	NUM
bibechana-25870	95	28	)	)	PUNCT
bibechana-25870	95	29	are	be	AUX
bibechana-25870	95	30	comparable	comparable	ADJ
bibechana-25870	95	31	to	to	ADP
bibechana-25870	95	32	afm	afm	PROPN
bibechana-25870	95	33	results	result	NOUN
bibechana-25870	95	34	even	even	ADV
bibechana-25870	95	35	at	at	ADP
bibechana-25870	95	36	this	this	DET
bibechana-25870	95	37	pulling	pull	VERB
bibechana-25870	95	38	speed	speed	NOUN
bibechana-25870	95	39	of	of	ADP
bibechana-25870	95	40	0.1	0.1	NUM
bibechana-25870	95	41	å	å	NOUN
bibechana-25870	95	42	/	/	SYM
bibechana-25870	95	43	ps	ps	NOUN
bibechana-25870	95	44	.	.	PUNCT
bibechana-25870	96	1	the	the	DET
bibechana-25870	96	2	smd	smd	NOUN
bibechana-25870	96	3	technique	technique	NOUN
bibechana-25870	96	4	of	of	ADP
bibechana-25870	96	5	crack	crack	NOUN
bibechana-25870	96	6	propagation	propagation	NOUN
bibechana-25870	96	7	allows	allow	VERB
bibechana-25870	96	8	the	the	DET
bibechana-25870	96	9	identification	identification	NOUN
bibechana-25870	96	10	of	of	ADP
bibechana-25870	96	11	intermediate	intermediate	ADJ
bibechana-25870	96	12	conformations	conformation	NOUN
bibechana-25870	96	13	of	of	ADP
bibechana-25870	96	14	thrt3	thrt3	PRON
bibechana-25870	96	15	responsible	responsible	ADJ
bibechana-25870	96	16	for	for	ADP
bibechana-25870	96	17	the	the	DET
bibechana-25870	96	18	gene	gene	NOUN
bibechana-25870	96	19	transcriptional	transcriptional	ADJ
bibechana-25870	96	20	activities	activity	NOUN
bibechana-25870	96	21	.	.	PUNCT
bibechana-25870	97	1	4	4	X
bibechana-25870	97	2	.	.	X
bibechana-25870	97	3	conclusion	conclusion	NOUN
bibechana-25870	97	4	triiodothyronine	triiodothyronine	VERB
bibechana-25870	97	5	nuclear	nuclear	ADJ
bibechana-25870	97	6	receptor	receptor	NOUN
bibechana-25870	97	7	(	(	PUNCT
bibechana-25870	97	8	thrt3	thrt3	NOUN
bibechana-25870	97	9	)	)	PUNCT
bibechana-25870	97	10	is	be	AUX
bibechana-25870	97	11	completely	completely	ADV
bibechana-25870	97	12	unfolded	unfold	VERB
bibechana-25870	97	13	resulting	result	VERB
bibechana-25870	97	14	end	end	NOUN
bibechana-25870	97	15	-	-	PUNCT
bibechana-25870	97	16	to	to	ADP
bibechana-25870	97	17	-	-	PUNCT
bibechana-25870	97	18	end	end	NOUN
bibechana-25870	97	19	length	length	NOUN
bibechana-25870	97	20	of	of	ADP
bibechana-25870	97	21	876	876	NUM
bibechana-25870	97	22	å	å	NOUN
bibechana-25870	97	23	by	by	ADP
bibechana-25870	97	24	8.5	8.5	NUM
bibechana-25870	97	25	ns	ns	NUM
bibechana-25870	97	26	long	long	ADJ
bibechana-25870	97	27	smd	smd	NOUN
bibechana-25870	97	28	simulations	simulation	NOUN
bibechana-25870	97	29	performed	perform	VERB
bibechana-25870	97	30	at	at	ADP
bibechana-25870	97	31	constant	constant	ADJ
bibechana-25870	97	32	velocity	velocity	NOUN
bibechana-25870	97	33	of	of	ADP
bibechana-25870	97	34	0.1	0.1	NUM
bibechana-25870	97	35	å	å	NOUN
bibechana-25870	97	36	/	/	SYM
bibechana-25870	97	37	ps	ps	NOUN
bibechana-25870	97	38	.	.	PUNCT
bibechana-25870	98	1	the	the	DET
bibechana-25870	98	2	peak	peak	NOUN
bibechana-25870	98	3	force	force	NOUN
bibechana-25870	98	4	associated	associate	VERB
bibechana-25870	98	5	with	with	ADP
bibechana-25870	98	6	the	the	DET
bibechana-25870	98	7	intermediate	intermediate	ADJ
bibechana-25870	98	8	conformations	conformation	NOUN
bibechana-25870	98	9	is	be	AUX
bibechana-25870	98	10	due	due	ADJ
bibechana-25870	98	11	to	to	ADP
bibechana-25870	98	12	breaking	break	VERB
bibechana-25870	98	13	of	of	ADP
bibechana-25870	98	14	h	h	NOUN
bibechana-25870	98	15	-	-	PUNCT
bibechana-25870	98	16	bonds	bond	NOUN
bibechana-25870	98	17	among	among	ADP
bibechana-25870	98	18	-helices	-helices	PROPN
bibechana-25870	98	19	and	and	CCONJ
bibechana-25870	98	20	hairpins	hairpin	NOUN
bibechana-25870	98	21	.	.	PUNCT
bibechana-25870	99	1	though	though	SCONJ
bibechana-25870	99	2	rmsd	rmsd	PROPN
bibechana-25870	99	3	of	of	ADP
bibechana-25870	99	4	t3	t3	PROPN
bibechana-25870	99	5	does	do	AUX
bibechana-25870	99	6	not	not	PART
bibechana-25870	99	7	exceed	exceed	VERB
bibechana-25870	99	8	2.5	2.5	NUM
bibechana-25870	99	9	å	å	NOUN
bibechana-25870	99	10	throughout	throughout	ADP
bibechana-25870	99	11	the	the	DET
bibechana-25870	99	12	simulation	simulation	NOUN
bibechana-25870	99	13	,	,	PUNCT
bibechana-25870	99	14	t3	t3	PROPN
bibechana-25870	99	15	is	be	AUX
bibechana-25870	99	16	deviated	deviate	VERB
bibechana-25870	99	17	more	more	ADV
bibechana-25870	99	18	from	from	ADP
bibechana-25870	99	19	its	its	PRON
bibechana-25870	99	20	mean	mean	ADJ
bibechana-25870	99	21	position	position	NOUN
bibechana-25870	99	22	in	in	ADP
bibechana-25870	99	23	the	the	DET
bibechana-25870	99	24	conformational	conformational	ADJ
bibechana-25870	99	25	states	state	NOUN
bibechana-25870	99	26	of	of	ADP
bibechana-25870	99	27	peak	peak	NOUN
bibechana-25870	99	28	force	force	NOUN
bibechana-25870	99	29	generation	generation	NOUN
bibechana-25870	99	30	.	.	PUNCT
bibechana-25870	100	1	hydrophobic	hydrophobic	PROPN
bibechana-25870	100	2	lbd	lbd	PROPN
bibechana-25870	100	3	,	,	PUNCT
bibechana-25870	100	4	i.e.	i.e.	X
bibechana-25870	100	5	t3	t3	NOUN
bibechana-25870	100	6	binding	bind	VERB
bibechana-25870	100	7	pocket	pocket	NOUN
bibechana-25870	100	8	of	of	ADP
bibechana-25870	100	9	the	the	DET
bibechana-25870	100	10	receptor	receptor	NOUN
bibechana-25870	100	11	that	that	PRON
bibechana-25870	100	12	gets	get	AUX
bibechana-25870	100	13	surrounded	surround	VERB
bibechana-25870	100	14	by	by	ADP
bibechana-25870	100	15	water	water	NOUN
bibechana-25870	100	16	is	be	AUX
bibechana-25870	100	17	unfolded	unfold	VERB
bibechana-25870	100	18	only	only	ADV
bibechana-25870	100	19	in	in	ADP
bibechana-25870	100	20	the	the	DET
bibechana-25870	100	21	last	last	NOUN
bibechana-25870	100	22	of	of	ADP
bibechana-25870	100	23	the	the	DET
bibechana-25870	100	24	simulation	simulation	NOUN
bibechana-25870	100	25	.	.	PUNCT
bibechana-25870	101	1	it	it	PRON
bibechana-25870	101	2	is	be	AUX
bibechana-25870	101	3	an	an	DET
bibechana-25870	101	4	evidence	evidence	NOUN
bibechana-25870	101	5	for	for	ADP
bibechana-25870	101	6	the	the	DET
bibechana-25870	101	7	stability	stability	NOUN
bibechana-25870	101	8	of	of	ADP
bibechana-25870	101	9	thr-	thr-	PROPN
bibechana-25870	101	10	lbd	lbd	PROPN
bibechana-25870	101	11	towards	towards	ADP
bibechana-25870	101	12	ligand	ligand	PROPN
bibechana-25870	101	13	(	(	PUNCT
bibechana-25870	101	14	t3	t3	NOUN
bibechana-25870	101	15	)	)	PUNCT
bibechana-25870	101	16	binding	binding	NOUN
bibechana-25870	101	17	and	and	CCONJ
bibechana-25870	101	18	dissociation	dissociation	NOUN
bibechana-25870	101	19	.	.	PUNCT
bibechana-25870	102	1	even	even	ADV
bibechana-25870	102	2	after	after	ADP
bibechana-25870	102	3	complete	complete	ADJ
bibechana-25870	102	4	stretching	stretching	NOUN
bibechana-25870	102	5	of	of	ADP
bibechana-25870	102	6	the	the	DET
bibechana-25870	102	7	protein	protein	NOUN
bibechana-25870	102	8	strand	strand	NOUN
bibechana-25870	102	9	lbd	lbd	PROPN
bibechana-25870	102	10	,	,	PUNCT
bibechana-25870	102	11	the	the	DET
bibechana-25870	102	12	position	position	NOUN
bibechana-25870	102	13	of	of	ADP
bibechana-25870	102	14	t3	t3	PROPN
bibechana-25870	102	15	remains	remain	VERB
bibechana-25870	102	16	almost	almost	ADV
bibechana-25870	102	17	constant	constant	ADJ
bibechana-25870	102	18	surrounded	surround	VERB
bibechana-25870	102	19	by	by	ADP
bibechana-25870	102	20	water	water	NOUN
bibechana-25870	102	21	molecules	molecule	NOUN
bibechana-25870	102	22	.	.	PUNCT
bibechana-25870	103	1	along	along	ADP
bibechana-25870	103	2	with	with	ADP
bibechana-25870	103	3	decrease	decrease	NOUN
bibechana-25870	103	4	in	in	ADP
bibechana-25870	103	5	h	h	NOUN
bibechana-25870	103	6	-	-	PUNCT
bibechana-25870	103	7	bonds	bond	NOUN
bibechana-25870	103	8	,	,	PUNCT
bibechana-25870	103	9	electrostatic	electrostatic	ADJ
bibechana-25870	103	10	energy	energy	NOUN
bibechana-25870	103	11	increases	increase	VERB
bibechana-25870	103	12	gently	gently	ADV
bibechana-25870	103	13	during	during	ADP
bibechana-25870	103	14	unfolding	unfold	VERB
bibechana-25870	103	15	.	.	PUNCT
bibechana-25870	104	1	there	there	PRON
bibechana-25870	104	2	are	be	VERB
bibechana-25870	104	3	linear	linear	ADJ
bibechana-25870	104	4	changes	change	NOUN
bibechana-25870	104	5	with	with	ADP
bibechana-25870	104	6	slightly	slightly	ADV
bibechana-25870	104	7	decreased	decrease	VERB
bibechana-25870	104	8	kinetic	kinetic	ADJ
bibechana-25870	104	9	energy	energy	NOUN
bibechana-25870	104	10	and	and	CCONJ
bibechana-25870	104	11	slightly	slightly	ADV
bibechana-25870	104	12	increased	increase	VERB
bibechana-25870	104	13	van	van	PROPN
bibechana-25870	104	14	der	der	NOUN
bibechana-25870	104	15	waals	waal	NOUN
bibechana-25870	104	16	energy	energy	NOUN
bibechana-25870	104	17	at	at	ADP
bibechana-25870	104	18	this	this	DET
bibechana-25870	104	19	constant	constant	ADJ
bibechana-25870	104	20	velocity	velocity	NOUN
bibechana-25870	104	21	pulling	pull	VERB
bibechana-25870	104	22	.	.	PUNCT
bibechana-25870	105	1	however	however	ADV
bibechana-25870	105	2	,	,	PUNCT
bibechana-25870	105	3	force	force	NOUN
bibechana-25870	105	4	or	or	CCONJ
bibechana-25870	105	5	net	net	ADJ
bibechana-25870	105	6	potential	potential	NOUN
bibechana-25870	105	7	of	of	ADP
bibechana-25870	105	8	the	the	DET
bibechana-25870	105	9	system	system	NOUN
bibechana-25870	105	10	increases	increase	VERB
bibechana-25870	105	11	rapidly	rapidly	ADV
bibechana-25870	105	12	at	at	ADP
bibechana-25870	105	13	the	the	DET
bibechana-25870	105	14	end	end	NOUN
bibechana-25870	105	15	(	(	PUNCT
bibechana-25870	105	16	t	t	X
bibechana-25870	105	17	>	>	X
bibechana-25870	105	18	8.5	8.5	NUM
bibechana-25870	105	19	ns	ns	NUM
bibechana-25870	105	20	)	)	PUNCT
bibechana-25870	105	21	of	of	ADP
bibechana-25870	105	22	the	the	DET
bibechana-25870	105	23	simulation	simulation	NOUN
bibechana-25870	105	24	.	.	PUNCT
bibechana-25870	106	1	dihedral	dihedral	PROPN
bibechana-25870	106	2	and	and	CCONJ
bibechana-25870	106	3	improper	improper	ADJ
bibechana-25870	106	4	energies	energy	NOUN
bibechana-25870	106	5	remain	remain	VERB
bibechana-25870	106	6	almost	almost	ADV
bibechana-25870	106	7	unchanged	unchanged	ADJ
bibechana-25870	106	8	throughout	throughout	ADP
bibechana-25870	106	9	the	the	DET
bibechana-25870	106	10	smd	smd	NOUN
bibechana-25870	106	11	simulations	simulation	NOUN
bibechana-25870	106	12	,	,	PUNCT
bibechana-25870	106	13	but	but	CCONJ
bibechana-25870	106	14	bond	bond	NOUN
bibechana-25870	106	15	-	-	PUNCT
bibechana-25870	106	16	angle	angle	NOUN
bibechana-25870	106	17	and	and	CCONJ
bibechana-25870	106	18	bond	bond	NOUN
bibechana-25870	106	19	-	-	PUNCT
bibechana-25870	106	20	length	length	NOUN
bibechana-25870	106	21	energies	energy	NOUN
bibechana-25870	106	22	increase	increase	VERB
bibechana-25870	106	23	steeply	steeply	ADV
bibechana-25870	106	24	after	after	ADP
bibechana-25870	106	25	complete	complete	ADJ
bibechana-25870	106	26	unfolding	unfolding	NOUN
bibechana-25870	106	27	(	(	PUNCT
bibechana-25870	106	28	t	t	X
bibechana-25870	106	29	>	>	X
bibechana-25870	106	30	8.5	8.5	NUM
bibechana-25870	106	31	ns	ns	NUM
bibechana-25870	106	32	)	)	PUNCT
bibechana-25870	106	33	of	of	ADP
bibechana-25870	106	34	the	the	DET
bibechana-25870	106	35	system	system	NOUN
bibechana-25870	106	36	.	.	PUNCT
bibechana-25870	107	1	thus	thus	ADV
bibechana-25870	107	2	,	,	PUNCT
bibechana-25870	107	3	one	one	NUM
bibechana-25870	107	4	dimensional	dimensional	ADJ
bibechana-25870	107	5	mechanical	mechanical	ADJ
bibechana-25870	107	6	pulling	pull	VERB
bibechana-25870	107	7	at	at	ADP
bibechana-25870	107	8	constant	constant	ADJ
bibechana-25870	107	9	velocity	velocity	NOUN
bibechana-25870	107	10	is	be	AUX
bibechana-25870	107	11	important	important	ADJ
bibechana-25870	107	12	technique	technique	NOUN
bibechana-25870	107	13	to	to	PART
bibechana-25870	107	14	better	well	ADV
bibechana-25870	107	15	understand	understand	VERB
bibechana-25870	107	16	the	the	DET
bibechana-25870	107	17	unfolding	unfold	VERB
bibechana-25870	107	18	pathways	pathway	NOUN
bibechana-25870	107	19	of	of	ADP
bibechana-25870	107	20	thrt3	thrt3	PRON
bibechana-25870	107	21	like	like	ADP
bibechana-25870	107	22	nuclear	nuclear	ADJ
bibechana-25870	107	23	receptors	receptor	NOUN
bibechana-25870	107	24	.	.	PUNCT
bibechana-25870	108	1	acknowledgements	acknowledgement	NOUN
bibechana-25870	108	2	we	we	PRON
bibechana-25870	108	3	would	would	AUX
bibechana-25870	108	4	like	like	VERB
bibechana-25870	108	5	to	to	PART
bibechana-25870	108	6	acknowledge	acknowledge	VERB
bibechana-25870	108	7	the	the	DET
bibechana-25870	108	8	computing	compute	VERB
bibechana-25870	108	9	resources	resource	NOUN
bibechana-25870	108	10	provided	provide	VERB
bibechana-25870	108	11	by	by	ADP
bibechana-25870	108	12	prof	prof	PROPN
bibechana-25870	108	13	.	.	PUNCT
bibechana-25870	109	1	dr	dr	PROPN
bibechana-25870	109	2	.	.	PROPN
bibechana-25870	109	3	raju	raju	PROPN
bibechana-25870	109	4	khanal	khanal	NOUN
bibechana-25870	109	5	at	at	ADP
bibechana-25870	109	6	his	his	PRON
bibechana-25870	109	7	plasma	plasma	NOUN
bibechana-25870	109	8	lab	lab	NOUN
bibechana-25870	109	9	,	,	PUNCT
bibechana-25870	109	10	central	central	ADJ
bibechana-25870	109	11	department	department	NOUN
bibechana-25870	109	12	of	of	ADP
bibechana-25870	109	13	physics	physics	PROPN
bibechana-25870	109	14	,	,	PUNCT
bibechana-25870	109	15	tribhuvan	tribhuvan	PROPN
bibechana-25870	109	16	university	university	PROPN
bibechana-25870	109	17	,	,	PUNCT
bibechana-25870	109	18	kathmandu	kathmandu	NOUN
bibechana-25870	109	19	,	,	PUNCT
bibechana-25870	109	20	nepal	nepal	ADJ
bibechana-25870	109	21	.	.	PUNCT
bibechana-25870	110	1	the	the	DET
bibechana-25870	110	2	partial	partial	ADJ
bibechana-25870	110	3	financial	financial	ADJ
bibechana-25870	110	4	support	support	NOUN
bibechana-25870	110	5	for	for	ADP
bibechana-25870	110	6	this	this	DET
bibechana-25870	110	7	research	research	NOUN
bibechana-25870	110	8	has	have	AUX
bibechana-25870	110	9	been	be	AUX
bibechana-25870	110	10	provided	provide	VERB
bibechana-25870	110	11	by	by	ADP
bibechana-25870	110	12	nepal	nepal	PROPN
bibechana-25870	110	13	academy	academy	PROPN
bibechana-25870	110	14	of	of	ADP
bibechana-25870	110	15	science	science	NOUN
bibechana-25870	110	16	and	and	CCONJ
bibechana-25870	110	17	technology	technology	NOUN
bibechana-25870	110	18	as	as	ADP
bibechana-25870	110	19	the	the	DET
bibechana-25870	110	20	phd	phd	NOUN
bibechana-25870	110	21	fellowship	fellowship	NOUN
bibechana-25870	110	22	to	to	ADP
bibechana-25870	110	23	the	the	DET
bibechana-25870	110	24	first	first	ADJ
bibechana-25870	110	25	author	author	NOUN
bibechana-25870	110	26	.	.	PUNCT
bibechana-25870	111	1	references	reference	NOUN
bibechana-25870	111	2	[	[	X
bibechana-25870	111	3	1	1	X
bibechana-25870	111	4	]	]	PUNCT
bibechana-25870	111	5	s.	s.	PROPN
bibechana-25870	111	6	izrailev	izrailev	PROPN
bibechana-25870	111	7	,	,	PUNCT
bibechana-25870	111	8	s.	s.	PROPN
bibechana-25870	111	9	stepaniants	stepaniants	PROPN
bibechana-25870	111	10	,	,	PUNCT
bibechana-25870	111	11	b.	b.	PROPN
bibechana-25870	111	12	isralewitz	isralewitz	PROPN
bibechana-25870	111	13	,	,	PUNCT
bibechana-25870	111	14	d.	d.	PROPN
bibechana-25870	111	15	kosztin	kosztin	PROPN
bibechana-25870	111	16	,	,	PUNCT
bibechana-25870	111	17	h.	h.	PROPN
bibechana-25870	111	18	lu	lu	PROPN
bibechana-25870	111	19	,	,	PUNCT
bibechana-25870	111	20	f.	f.	PROPN
bibechana-25870	111	21	molnar	molnar	PROPN
bibechana-25870	111	22	,	,	PUNCT
bibechana-25870	111	23	w.	w.	PROPN
bibechana-25870	111	24	wriggers	wriggers	PROPN
bibechana-25870	111	25	,	,	PUNCT
bibechana-25870	111	26	k.	k.	PROPN
bibechana-25870	111	27	schulten	schulten	PROPN
bibechana-25870	111	28	,	,	PUNCT
bibechana-25870	111	29	steered	steer	VERB
bibechana-25870	111	30	molecular	molecular	ADJ
bibechana-25870	111	31	dynamics	dynamic	NOUN
bibechana-25870	111	32	,	,	PUNCT
bibechana-25870	111	33	computational	computational	ADJ
bibechana-25870	111	34	molecular	molecular	ADJ
bibechana-25870	111	35	dynamics	dynamic	NOUN
bibechana-25870	111	36	:	:	PUNCT
bibechana-25870	111	37	challenges	challenge	NOUN
bibechana-25870	111	38	,	,	PUNCT
bibechana-25870	111	39	methods	method	NOUN
bibechana-25870	111	40	,	,	PUNCT
bibechana-25870	111	41	ideas	idea	NOUN
bibechana-25870	111	42	,	,	PUNCT
bibechana-25870	111	43	(	(	PUNCT
bibechana-25870	111	44	1999	1999	NUM
bibechana-25870	111	45	)	)	PUNCT
bibechana-25870	111	46	39	39	NUM
bibechana-25870	111	47	-	-	SYM
bibechana-25870	111	48	65	65	NUM
bibechana-25870	111	49	,	,	PUNCT
bibechana-25870	111	50	springer	springer	NOUN
bibechana-25870	111	51	,	,	PUNCT
bibechana-25870	111	52	berlin	berlin	PROPN
bibechana-25870	111	53	,	,	PUNCT
bibechana-25870	111	54	heidelberg	heidelberg	PROPN
bibechana-25870	111	55	.	.	PUNCT
bibechana-25870	112	1	[	[	X
bibechana-25870	112	2	2	2	X
bibechana-25870	112	3	]	]	PUNCT
bibechana-25870	112	4	t.	t.	PROPN
bibechana-25870	112	5	m.	m.	PROPN
bibechana-25870	112	6	ortiga	ortiga	PROPN
bibechana-25870	112	7	-	-	PUNCT
bibechana-25870	112	8	carvalho	carvalho	NOUN
bibechana-25870	112	9	,	,	PUNCT
bibechana-25870	112	10	a.	a.	PROPN
bibechana-25870	112	11	r.	r.	PROPN
bibechana-25870	112	12	sidhaye	sidhaye	PROPN
bibechana-25870	112	13	,	,	PUNCT
bibechana-25870	112	14	f.	f.	PROPN
bibechana-25870	112	15	e.	e.	PROPN
bibechana-25870	112	16	wondisford	wondisford	PROPN
bibechana-25870	112	17	,	,	PUNCT
bibechana-25870	112	18	thyroid	thyroid	NOUN
bibechana-25870	112	19	hormone	hormone	NOUN
bibechana-25870	112	20	receptors	receptor	NOUN
bibechana-25870	112	21	and	and	CCONJ
bibechana-25870	112	22	resistance	resistance	NOUN
bibechana-25870	112	23	to	to	PART
bibechana-25870	112	24	thyroid	thyroid	VERB
bibechana-25870	112	25	hormone	hormone	NOUN
bibechana-25870	112	26	disorders	disorder	NOUN
bibechana-25870	112	27	,	,	PUNCT
bibechana-25870	112	28	nature	nature	NOUN
bibechana-25870	112	29	rev	rev	VERB
bibechana-25870	112	30	.	.	PROPN
bibechana-25870	112	31	endocrinol	endocrinol	NOUN
bibechana-25870	112	32	10	10	NUM
bibechana-25870	112	33	(	(	PUNCT
bibechana-25870	112	34	2014	2014	NUM
bibechana-25870	112	35	)	)	PUNCT
bibechana-25870	112	36	582	582	NUM
bibechana-25870	112	37	.	.	PUNCT
bibechana-25870	113	1	doi.org/10.1038/nrendo.2014.143	doi.org/10.1038/nrendo.2014.143	NOUN
bibechana-25870	114	1	[	[	X
bibechana-25870	114	2	3	3	X
bibechana-25870	114	3	]	]	PUNCT
bibechana-25870	114	4	t.	t.	PROPN
bibechana-25870	114	5	r.	r.	PROPN
bibechana-25870	114	6	lamichhane	lamichhane	PROPN
bibechana-25870	114	7	,	,	PUNCT
bibechana-25870	114	8	s.	s.	PROPN
bibechana-25870	114	9	paudel	paudel	PROPN
bibechana-25870	114	10	,	,	PUNCT
bibechana-25870	114	11	b.	b.	PROPN
bibechana-25870	114	12	k.	k.	PROPN
bibechana-25870	114	13	yadav	yadav	PROPN
bibechana-25870	114	14	,	,	PUNCT
bibechana-25870	114	15	h.	h.	PROPN
bibechana-25870	114	16	p.	p.	PROPN
bibechana-25870	114	17	lamichhane	lamichhane	PROPN
bibechana-25870	114	18	,	,	PUNCT
bibechana-25870	114	19	echo	echo	NOUN
bibechana-25870	114	20	dephasing	dephase	VERB
bibechana-25870	114	21	and	and	CCONJ
bibechana-25870	114	22	heat	heat	NOUN
bibechana-25870	114	23	capacity	capacity	NOUN
bibechana-25870	114	24	https://dx.doi.org/10.1038%2fnrendo.2014.143	https://dx.doi.org/10.1038%2fnrendo.2014.143	NOUN
bibechana-25870	114	25	tika	tika	PROPN
bibechana-25870	114	26	ram	ram	PROPN
bibechana-25870	114	27	lamichhane	lamichhane	NOUN
bibechana-25870	114	28	,	,	PUNCT
bibechana-25870	114	29	hari	hari	PROPN
bibechana-25870	114	30	prasad	prasad	PROPN
bibechana-25870	114	31	lamichhane	lamichhane	PROPN
bibechana-25870	114	32	/	/	SYM
bibechana-25870	114	33	bibechana	bibechana	PROPN
bibechana-25870	114	34	17	17	NUM
bibechana-25870	114	35	(	(	PUNCT
bibechana-25870	114	36	2020	2020	NUM
bibechana-25870	114	37	)	)	PUNCT
bibechana-25870	114	38	50	50	NUM
bibechana-25870	114	39	-	-	SYM
bibechana-25870	114	40	57	57	NUM
bibechana-25870	114	41	57	57	NUM
bibechana-25870	114	42	from	from	ADP
bibechana-25870	114	43	constrained	constrain	VERB
bibechana-25870	114	44	and	and	CCONJ
bibechana-25870	114	45	unconstrained	unconstrained	ADJ
bibechana-25870	114	46	dynamics	dynamic	NOUN
bibechana-25870	114	47	of	of	ADP
bibechana-25870	114	48	triiodothyronine	triiodothyronine	ADJ
bibechana-25870	114	49	nuclear	nuclear	ADJ
bibechana-25870	114	50	receptor	receptor	NOUN
bibechana-25870	114	51	protein	protein	NOUN
bibechana-25870	114	52	,	,	PUNCT
bibechana-25870	114	53	j.	j.	PROPN
bibechana-25870	114	54	biol	biol	PROPN
bibechana-25870	114	55	.	.	PUNCT
bibechana-25870	115	1	phys	phy	NOUN
bibechana-25870	115	2	.	.	PUNCT
bibechana-25870	116	1	45(2019	45(2019	NUM
bibechana-25870	116	2	)	)	PUNCT
bibechana-25870	116	3	107	107	NUM
bibechana-25870	116	4	-	-	SYM
bibechana-25870	116	5	135	135	NUM
bibechana-25870	116	6	.	.	PUNCT
bibechana-25870	117	1	doi.org/10.1007/s10867-018-9518-3	doi.org/10.1007/s10867-018-9518-3	NOUN
bibechana-25870	117	2	[	[	X
bibechana-25870	117	3	4	4	X
bibechana-25870	117	4	]	]	PUNCT
bibechana-25870	117	5	t.	t.	PROPN
bibechana-25870	117	6	r.	r.	PROPN
bibechana-25870	117	7	lamichhane	lamichhane	PROPN
bibechana-25870	117	8	,	,	PUNCT
bibechana-25870	117	9	h.	h.	PROPN
bibechana-25870	117	10	p.	p.	PROPN
bibechana-25870	117	11	lamichhane	lamichhane	PROPN
bibechana-25870	117	12	,	,	PUNCT
bibechana-25870	117	13	heat	heat	NOUN
bibechana-25870	117	14	conduction	conduction	NOUN
bibechana-25870	117	15	by	by	ADP
bibechana-25870	117	16	thyroid	thyroid	NOUN
bibechana-25870	117	17	hormone	hormone	NOUN
bibechana-25870	117	18	receptors	receptor	NOUN
bibechana-25870	117	19	,	,	PUNCT
bibechana-25870	117	20	aims	aim	VERB
bibechana-25870	117	21	biophys	biophy	NOUN
bibechana-25870	117	22	.	.	PUNCT
bibechana-25870	118	1	5(2018	5(2018	X
bibechana-25870	118	2	)	)	PUNCT
bibechana-25870	118	3	245	245	NUM
bibechana-25870	118	4	-	-	SYM
bibechana-25870	118	5	256	256	NUM
bibechana-25870	118	6	.	.	PUNCT
bibechana-25870	118	7	doi.org/10.3934/biophy.2018.4.245	doi.org/10.3934/biophy.2018.4.245	NOUN
bibechana-25870	119	1	[	[	X
bibechana-25870	119	2	5	5	X
bibechana-25870	119	3	]	]	PUNCT
bibechana-25870	119	4	t.	t.	PROPN
bibechana-25870	119	5	r.	r.	PROPN
bibechana-25870	119	6	lamichhane	lamichhane	PROPN
bibechana-25870	119	7	,	,	PUNCT
bibechana-25870	119	8	s.	s.	PROPN
bibechana-25870	119	9	paudel	paudel	PROPN
bibechana-25870	119	10	,	,	PUNCT
bibechana-25870	119	11	b.	b.	PROPN
bibechana-25870	119	12	k.	k.	PROPN
bibechana-25870	119	13	yadav	yadav	PROPN
bibechana-25870	119	14	,	,	PUNCT
bibechana-25870	119	15	h.	h.	PROPN
bibechana-25870	119	16	p.	p.	PROPN
bibechana-25870	119	17	lamichhane	lamichhane	NOUN
bibechana-25870	119	18	,	,	PUNCT
bibechana-25870	119	19	molecular	molecular	ADJ
bibechana-25870	119	20	dynamics	dynamic	NOUN
bibechana-25870	119	21	approach	approach	VERB
bibechana-25870	119	22	to	to	ADP
bibechana-25870	119	23	the	the	DET
bibechana-25870	119	24	i431v	i431v	PROPN
bibechana-25870	119	25	mutational	mutational	ADJ
bibechana-25870	119	26	impact	impact	NOUN
bibechana-25870	119	27	on	on	ADP
bibechana-25870	119	28	thyroid	thyroid	NOUN
bibechana-25870	119	29	hormone	hormone	NOUN
bibechana-25870	119	30	recep	recep	NOUN
bibechana-25870	119	31	tor	tor	NOUN
bibechana-25870	119	32	-beta	-beta	PROPN
bibechana-25870	119	33	,	,	PUNCT
bibechana-25870	119	34	bibechana	bibechana	NOUN
bibechana-25870	119	35	,	,	PUNCT
bibechana-25870	119	36	16	16	NUM
bibechana-25870	119	37	(	(	PUNCT
bibechana-25870	119	38	2019	2019	NUM
bibechana-25870	119	39	)	)	PUNCT
bibechana-25870	119	40	79	79	NUM
bibechana-25870	119	41	-	-	SYM
bibechana-25870	119	42	91	91	NUM
bibechana-25870	119	43	.	.	PUNCT
bibechana-25870	120	1	doi.org/10.3126/bibechana.v16i0.21109	doi.org/10.3126/bibechana.v16i0.21109	VERB
bibechana-25870	121	1	[	[	X
bibechana-25870	121	2	6	6	NUM
bibechana-25870	121	3	]	]	PUNCT
bibechana-25870	121	4	j.	j.	PROPN
bibechana-25870	121	5	j.	j.	PROPN
bibechana-25870	121	6	booth	booth	PROPN
bibechana-25870	121	7	,	,	PUNCT
bibechana-25870	121	8	d.	d.	PROPN
bibechana-25870	121	9	v.	v.	PROPN
bibechana-25870	121	10	shalashilin	shalashilin	PROPN
bibechana-25870	121	11	,	,	PUNCT
bibechana-25870	121	12	fully	fully	ADV
bibechana-25870	121	13	atomistic	atomistic	ADJ
bibechana-25870	121	14	simulations	simulation	NOUN
bibechana-25870	121	15	of	of	ADP
bibechana-25870	121	16	protein	protein	NOUN
bibechana-25870	121	17	unfolding	unfold	VERB
bibechana-25870	121	18	in	in	ADP
bibechana-25870	121	19	low	low	ADJ
bibechana-25870	121	20	speed	speed	NOUN
bibechana-25870	121	21	atomic	atomic	ADJ
bibechana-25870	121	22	force	force	NOUN
bibechana-25870	121	23	microscope	microscope	NOUN
bibechana-25870	121	24	and	and	CCONJ
bibechana-25870	121	25	force	force	VERB
bibechana-25870	121	26	clamp	clamp	NOUN
bibechana-25870	121	27	experiments	experiment	NOUN
bibechana-25870	121	28	with	with	ADP
bibechana-25870	121	29	the	the	DET
bibechana-25870	121	30	help	help	NOUN
bibechana-25870	121	31	of	of	ADP
bibechana-25870	121	32	boxed	box	VERB
bibechana-25870	121	33	molecular	molecular	ADJ
bibechana-25870	121	34	dynamics	dynamic	NOUN
bibechana-25870	121	35	,	,	PUNCT
bibechana-25870	121	36	j.	j.	PROPN
bibechana-25870	121	37	phys	phys	PROPN
bibechana-25870	121	38	.	.	PUNCT
bibechana-25870	122	1	chem	chem	PROPN
bibechana-25870	122	2	.	.	PUNCT
bibechana-25870	123	1	b	b	X
bibechana-25870	123	2	120	120	NUM
bibechana-25870	123	3	(	(	PUNCT
bibechana-25870	123	4	2016	2016	NUM
bibechana-25870	123	5	)	)	PUNCT
bibechana-25870	123	6	700	700	NUM
bibechana-25870	123	7	-	-	NUM
bibechana-25870	123	8	708	708	NUM
bibechana-25870	123	9	.	.	PUNCT
bibechana-25870	124	1	doi.org/10.1021/acs.jpcb.5b11519	doi.org/10.1021/acs.jpcb.5b11519	NOUN
bibechana-25870	124	2	[	[	X
bibechana-25870	124	3	7	7	X
bibechana-25870	124	4	]	]	PUNCT
bibechana-25870	124	5	z.	z.	PROPN
bibechana-25870	124	6	mártonfalvi	mártonfalvi	PROPN
bibechana-25870	124	7	,	,	PUNCT
bibechana-25870	124	8	p.	p.	PROPN
bibechana-25870	124	9	bianco	bianco	PROPN
bibechana-25870	124	10	,	,	PUNCT
bibechana-25870	124	11	k.	k.	PROPN
bibechana-25870	124	12	naftz	naftz	PROPN
bibechana-25870	124	13	,	,	PUNCT
bibechana-25870	124	14	g.	g.	PROPN
bibechana-25870	124	15	g.	g.	PROPN
bibechana-25870	124	16	ferenczy	ferenczy	PROPN
bibechana-25870	124	17	,	,	PUNCT
bibechana-25870	124	18	m.	m.	PROPN
bibechana-25870	124	19	kellermayer	kellermayer	PROPN
bibechana-25870	124	20	,	,	PUNCT
bibechana-25870	124	21	force	force	NOUN
bibechana-25870	124	22	generation	generation	NOUN
bibechana-25870	124	23	by	by	ADP
bibechana-25870	124	24	titin	titin	PROPN
bibechana-25870	124	25	folding	folding	NOUN
bibechana-25870	124	26	,	,	PUNCT
bibechana-25870	124	27	protein	protein	NOUN
bibechana-25870	124	28	sci	sci	PROPN
bibechana-25870	124	29	26	26	NUM
bibechana-25870	124	30	(	(	PUNCT
bibechana-25870	124	31	2017	2017	NUM
bibechana-25870	124	32	)	)	PUNCT
bibechana-25870	124	33	1380	1380	NUM
bibechana-25870	124	34	-	-	SYM
bibechana-25870	124	35	1390	1390	NUM
bibechana-25870	124	36	.	.	PUNCT
bibechana-25870	125	1	https://doi.org/10.1002/pro.3117	https://doi.org/10.1002/pro.3117	PROPN
bibechana-25870	126	1	[	[	X
bibechana-25870	126	2	8	8	NUM
bibechana-25870	126	3	]	]	PUNCT
bibechana-25870	126	4	j.	j.	PROPN
bibechana-25870	126	5	schönfelder	schönfelder	PROPN
bibechana-25870	126	6	,	,	PUNCT
bibechana-25870	126	7	d.	d.	PROPN
bibechana-25870	126	8	de	de	PROPN
bibechana-25870	126	9	sancho	sancho	PROPN
bibechana-25870	126	10	,	,	PUNCT
bibechana-25870	126	11	r.	r.	PROPN
bibechana-25870	126	12	perez	perez	PROPN
bibechana-25870	126	13	-	-	PUNCT
bibechana-25870	126	14	jimenez	jimenez	PROPN
bibechana-25870	126	15	,	,	PUNCT
bibechana-25870	126	16	the	the	DET
bibechana-25870	126	17	power	power	NOUN
bibechana-25870	126	18	of	of	ADP
bibechana-25870	126	19	force	force	NOUN
bibechana-25870	126	20	:	:	PUNCT
bibechana-25870	126	21	insights	insight	NOUN
bibechana-25870	126	22	into	into	ADP
bibechana-25870	126	23	the	the	DET
bibechana-25870	126	24	protein	protein	NOUN
bibechana-25870	126	25	folding	fold	VERB
bibechana-25870	126	26	process	process	NOUN
bibechana-25870	126	27	using	use	VERB
bibechana-25870	126	28	single	single	ADJ
bibechana-25870	126	29	-	-	PUNCT
bibechana-25870	126	30	molecule	molecule	NOUN
bibechana-25870	126	31	fo	fo	ADP
bibechana-25870	126	32	rce	rce	PROPN
bibechana-25870	126	33	spec	spec	PROPN
bibechana-25870	126	34	troscopy	troscopy	PROPN
bibechana-25870	126	35	,	,	PUNCT
bibechana-25870	126	36	j.	j.	PROPN
bibechana-25870	126	37	mol	mol	PROPN
bibechana-25870	126	38	.	.	PUNCT
bibechana-25870	126	39	biol	biol	PROPN
bibechana-25870	126	40	.	.	PUNCT
bibechana-25870	127	1	428	428	NUM
bibechana-25870	127	2	(	(	PUNCT
bibechana-25870	127	3	2016	2016	NUM
bibechana-25870	127	4	)	)	PUNCT
bibechana-25870	127	5	42454257	42454257	NUM
bibechana-25870	127	6	.	.	PUNCT
bibechana-25870	128	1	doi.org/10.1016/j.jmb.2016.09.006	doi.org/10.1016/j.jmb.2016.09.006	PROPN
bibechana-25870	128	2	[	[	X
bibechana-25870	128	3	9	9	NUM
bibechana-25870	128	4	]	]	PUNCT
bibechana-25870	128	5	d.	d.	PROPN
bibechana-25870	128	6	l.	l.	PROPN
bibechana-25870	128	7	guzmán	guzmán	PROPN
bibechana-25870	128	8	,	,	PUNCT
bibechana-25870	128	9	a.	a.	PROPN
bibechana-25870	128	10	randall	randall	PROPN
bibechana-25870	128	11	,	,	PUNCT
bibechana-25870	128	12	p.	p.	PROPN
bibechana-25870	128	13	baldi	baldi	PROPN
bibechana-25870	128	14	,	,	PUNCT
bibechana-25870	128	15	p.	p.	PROPN
bibechana-25870	128	16	,	,	PUNCT
bibechana-25870	128	17	z.	z.	PROPN
bibechana-25870	128	18	guan	guan	PROPN
bibechana-25870	128	19	,	,	PUNCT
bibechana-25870	128	20	computational	computational	ADJ
bibechana-25870	128	21	and	and	CCONJ
bibechana-25870	128	22	single	single	ADJ
bibechana-25870	128	23	-	-	PUNCT
bibechana-25870	128	24	molecule	molecule	NOUN
bibechana-25870	128	25	force	force	NOUN
bibechana-25870	128	26	studies	study	NOUN
bibechana-25870	128	27	of	of	ADP
bibechana-25870	128	28	a	a	DET
bibechana-25870	128	29	macro	macro	ADJ
bibechana-25870	128	30	domain	domain	NOUN
bibechana-25870	128	31	protein	protein	NOUN
bibechana-25870	128	32	reveal	reveal	VERB
bibechana-25870	128	33	a	a	DET
bibechana-25870	128	34	key	key	ADJ
bibechana-25870	128	35	molecular	molecular	ADJ
bibechana-25870	128	36	determinant	determinant	ADJ
bibechana-25870	128	37	for	for	ADP
bibechana-25870	128	38	mechanical	mechanical	ADJ
bibechana-25870	128	39	stability	stability	NOUN
bibechana-25870	128	40	.	.	PUNCT
bibechana-25870	129	1	proc	proc	PROPN
bibechana-25870	129	2	.	.	PUNCT
bibechana-25870	130	1	natl	natl	PROPN
bibechana-25870	130	2	.	.	PUNCT
bibechana-25870	131	1	acad	acad	PROPN
bibechana-25870	131	2	.	.	PUNCT
bibechana-25870	132	1	sci	sci	PROPN
bibechana-25870	132	2	.	.	PUNCT
bibechana-25870	132	3	u.	u.	PROPN
bibechana-25870	132	4	s.	s.	PROPN
bibechana-25870	132	5	a.	a.	PROPN
bibechana-25870	132	6	107(2010	107(2010	PROPN
bibechana-25870	132	7	)	)	PUNCT
bibechana-25870	132	8	1989	1989	NUM
bibechana-25870	132	9	-	-	SYM
bibechana-25870	132	10	1994	1994	NUM
bibechana-25870	132	11	.	.	PUNCT
bibechana-25870	133	1	doi.org/10.1073/pnas.0905796107	doi.org/10.1073/pnas.0905796107	PRON
bibechana-25870	133	2	[	[	X
bibechana-25870	133	3	10	10	NUM
bibechana-25870	133	4	]	]	X
bibechana-25870	133	5	l.	l.	PROPN
bibechana-25870	133	6	martínez	martínez	PROPN
bibechana-25870	133	7	,	,	PUNCT
bibechana-25870	133	8	i.	i.	PROPN
bibechana-25870	133	9	polikarpov	polikarpov	PROPN
bibechana-25870	133	10	,	,	PUNCT
bibechana-25870	133	11	m.	m.	NOUN
bibechana-25870	133	12	s.	s.	PROPN
bibechana-25870	133	13	skaf	skaf	PROPN
bibechana-25870	133	14	,	,	PUNCT
bibechana-25870	133	15	only	only	ADV
bibechana-25870	133	16	subtle	subtle	ADJ
bibechana-25870	133	17	protein	protein	NOUN
bibechana-25870	133	18	conformational	conformational	ADJ
bibechana-25870	133	19	adaptations	adaptation	NOUN
bibechana-25870	133	20	are	be	AUX
bibechana-25870	133	21	required	require	VERB
bibechana-25870	133	22	for	for	ADP
bibechana-25870	133	23	ligand	ligand	NOUN
bibechana-25870	133	24	binding	bind	VERB
bibechana-25870	133	25	to	to	PART
bibechana-25870	133	26	thyroid	thyroid	VERB
bibechana-25870	133	27	hormone	hormone	NOUN
bibechana-25870	133	28	receptors	receptor	NOUN
bibechana-25870	133	29	:	:	PUNCT
bibechana-25870	133	30	simulations	simulation	NOUN
bibechana-25870	133	31	using	use	VERB
bibechana-25870	133	32	a	a	DET
bibechana-25870	133	33	novel	novel	ADJ
bibechana-25870	133	34	multipoint	multipoint	NOUN
bibechana-25870	133	35	steered	steer	VERB
bibechana-25870	133	36	molecular	molecular	ADJ
bibechana-25870	133	37	dynamics	dynamic	NOUN
bibechana-25870	133	38	approach	approach	NOUN
bibechana-25870	133	39	,	,	PUNCT
bibechana-25870	133	40	j.	j.	PROPN
bibechana-25870	133	41	phys	phys	PROPN
bibechana-25870	133	42	.	.	PUNCT
bibechana-25870	134	1	chem	chem	PROPN
bibechana-25870	134	2	.	.	PUNCT
bibechana-25870	135	1	b	b	X
bibechana-25870	135	2	112(2008	112(2008	NOUN
bibechana-25870	135	3	)	)	PUNCT
bibechana-25870	135	4	10741	10741	NUM
bibechana-25870	135	5	-	-	SYM
bibechana-25870	135	6	10751	10751	NUM
bibechana-25870	135	7	.	.	PUNCT
bibechana-25870	136	1	doi.org/10.1021/jp803403c	doi.org/10.1021/jp803403c	PROPN
bibechana-25870	137	1	[	[	X
bibechana-25870	137	2	11]j	11]j	NUM
bibechana-25870	137	3	.	.	PUNCT
bibechana-25870	137	4	r.	r.	PROPN
bibechana-25870	137	5	gullingsrud	gullingsrud	PROPN
bibechana-25870	137	6	,	,	PUNCT
bibechana-25870	137	7	r.	r.	PROPN
bibechana-25870	137	8	braun	braun	PROPN
bibechana-25870	137	9	,	,	PUNCT
bibechana-25870	137	10	k.	k.	PROPN
bibechana-25870	137	11	schulten	schulten	PROPN
bibechana-25870	137	12	,	,	PUNCT
bibechana-25870	137	13	reconstructing	reconstruct	VERB
bibechana-25870	137	14	potentials	potential	NOUN
bibechana-25870	137	15	of	of	ADP
bibechana-25870	137	16	mean	mean	ADJ
bibechana-25870	137	17	force	force	NOUN
bibechana-25870	137	18	through	through	ADP
bibechana-25870	137	19	time	time	NOUN
bibechana-25870	137	20	series	series	NOUN
bibechana-25870	137	21	analysis	analysis	NOUN
bibechana-25870	137	22	of	of	ADP
bibechana-25870	137	23	steered	steered	ADJ
bibechana-25870	137	24	molecular	molecular	ADJ
bibechana-25870	137	25	dynamics	dynamic	NOUN
bibechana-25870	137	26	simulations	simulation	NOUN
bibechana-25870	137	27	,	,	PUNCT
bibechana-25870	137	28	j.	j.	PROPN
bibechana-25870	137	29	comp	comp	PROPN
bibechana-25870	137	30	.	.	PUNCT
bibechana-25870	138	1	phys	phy	NOUN
bibechana-25870	138	2	.	.	PUNCT
bibechana-25870	139	1	151(1999	151(1999	NUM
bibechana-25870	139	2	)	)	PUNCT
bibechana-25870	139	3	190	190	NUM
bibechana-25870	139	4	-	-	PUNCT
bibechana-25870	139	5	211	211	NUM
bibechana-25870	139	6	.	.	PUNCT
bibechana-25870	140	1	doi.org/10.1006/jcph.1999.6218	doi.org/10.1006/jcph.1999.6218	NOUN
bibechana-25870	141	1	[	[	X
bibechana-25870	141	2	12	12	NUM
bibechana-25870	141	3	]	]	X
bibechana-25870	141	4	a.s	a.s	PROPN
bibechana-25870	141	5	.	.	PROPN
bibechana-25870	141	6	nascimento	nascimento	PROPN
bibechana-25870	141	7	,	,	PUNCT
bibechana-25870	141	8	s.	s.	PROPN
bibechana-25870	141	9	m.	m.	PROPN
bibechana-25870	141	10	g.	g.	PROPN
bibechana-25870	141	11	dias	dias	PROPN
bibechana-25870	141	12	,	,	PUNCT
bibechana-25870	141	13	f.	f.	PROPN
bibechana-25870	141	14	m.	m.	PROPN
bibechana-25870	141	15	nunes	nunes	PROPN
bibechana-25870	141	16	,	,	PUNCT
bibechana-25870	141	17	r.	r.	PROPN
bibechana-25870	141	18	aparício	aparício	PROPN
bibechana-25870	141	19	,	,	PUNCT
bibechana-25870	141	20	a.	a.	PROPN
bibechana-25870	141	21	l.	l.	PROPN
bibechana-25870	141	22	ambrosio	ambrosio	PROPN
bibechana-25870	141	23	,	,	PUNCT
bibechana-25870	141	24	bleicher	bleicher	PROPN
bibechana-25870	141	25	,	,	PUNCT
bibechana-25870	141	26	l.	l.	PROPN
bibechana-25870	141	27	,	,	PUNCT
bibechana-25870	141	28	a.	a.	PROPN
bibechana-25870	141	29	c.	c.	PROPN
bibechana-25870	141	30	m.	m.	PROPN
bibechana-25870	141	31	figueira	figueira	PROPN
bibechana-25870	141	32	,	,	PUNCT
bibechana-25870	141	33	m.	m.	NOUN
bibechana-25870	141	34	a.	a.	PROPN
bibechana-25870	141	35	m.	m.	PROPN
bibechana-25870	141	36	santos	santos	PROPN
bibechana-25870	141	37	,	,	PUNCT
bibechana-25870	141	38	m.	m.	PROPN
bibechana-25870	141	39	de	de	PROPN
bibechana-25870	141	40	oliveira	oliveira	PROPN
bibechana-25870	141	41	neto	neto	PROPN
bibechana-25870	141	42	,	,	PUNCT
bibechana-25870	141	43	h.	h.	PROPN
bibechana-25870	141	44	fischer	fischer	PROPN
bibechana-25870	141	45	,	,	PUNCT
bibechana-25870	141	46	m.	m.	NOUN
bibechana-25870	141	47	togashi	togashi	PROPN
bibechana-25870	141	48	,	,	PUNCT
bibechana-25870	141	49	structural	structural	ADJ
bibechana-25870	141	50	rearrangements	rearrangement	NOUN
bibechana-25870	141	51	in	in	ADP
bibechana-25870	141	52	the	the	DET
bibechana-25870	141	53	thyroid	thyroid	NOUN
bibechana-25870	141	54	hormone	hormone	NOUN
bibechana-25870	141	55	receptor	receptor	NOUN
bibechana-25870	141	56	hinge	hinge	NOUN
bibechana-25870	141	57	domain	domain	NOUN
bibechana-25870	141	58	and	and	CCONJ
bibechana-25870	141	59	their	their	PRON
bibechana-25870	141	60	putative	putative	ADJ
bibechana-25870	141	61	role	role	NOUN
bibechana-25870	141	62	in	in	ADP
bibechana-25870	141	63	the	the	DET
bibechana-25870	141	64	receptor	receptor	NOUN
bibechana-25870	141	65	function	function	NOUN
bibechana-25870	141	66	,	,	PUNCT
bibechana-25870	141	67	j.	j.	PROPN
bibechana-25870	141	68	mol	mol	PROPN
bibechana-25870	141	69	.	.	PUNCT
bibechana-25870	142	1	biol	biol	PROPN
bibechana-25870	142	2	.	.	PUNCT
bibechana-25870	143	1	360	360	NUM
bibechana-25870	143	2	(	(	PUNCT
bibechana-25870	143	3	2006	2006	NUM
bibechana-25870	143	4	)	)	PUNCT
bibechana-25870	143	5	586	586	NUM
bibechana-25870	143	6	-	-	SYM
bibechana-25870	143	7	598	598	NUM
bibechana-25870	143	8	.	.	PUNCT
bibechana-25870	143	9	doi.org/10.1016/j.jmb.2006.05.008	doi.org/10.1016/j.jmb.2006.05.008	NOUN
bibechana-25870	143	10	[	[	X
bibechana-25870	143	11	13	13	NUM
bibechana-25870	143	12	]	]	PUNCT
bibechana-25870	143	13	w.	w.	PROPN
bibechana-25870	143	14	humphrey	humphrey	PROPN
bibechana-25870	143	15	,	,	PUNCT
bibechana-25870	143	16	a.	a.	PROPN
bibechana-25870	143	17	dalke	dalke	PROPN
bibechana-25870	143	18	,	,	PUNCT
bibechana-25870	143	19	k.	k.	PROPN
bibechana-25870	143	20	schulten	schulten	PROPN
bibechana-25870	143	21	,	,	PUNCT
bibechana-25870	143	22	vmd	vmd	PROPN
bibechana-25870	143	23	—	—	PUNCT
bibechana-25870	143	24	visual	visual	ADJ
bibechana-25870	143	25	molecular	molecular	ADJ
bibechana-25870	143	26	dynamics	dynamic	NOUN
bibechana-25870	143	27	,	,	PUNCT
bibechana-25870	143	28	j.	j.	PROPN
bibechana-25870	143	29	mol	mol	PROPN
bibechana-25870	143	30	.	.	PUNCT
bibechana-25870	143	31	graphics	graphic	NOUN
bibechana-25870	143	32	14	14	NUM
bibechana-25870	143	33	(	(	PUNCT
bibechana-25870	143	34	1996	1996	NUM
bibechana-25870	143	35	)	)	PUNCT
bibechana-25870	144	1	33–38	33–38	NUM
bibechana-25870	144	2	.	.	PUNCT
bibechana-25870	145	1	doi.org/10.1016/0263-7855(96)00018-5	doi.org/10.1016/0263-7855(96)00018-5	PROPN
bibechana-25870	146	1	[	[	X
bibechana-25870	146	2	14]w	14]w	NUM
bibechana-25870	146	3	.	.	PUNCT
bibechana-25870	147	1	humphrey	humphrey	PROPN
bibechana-25870	147	2	,	,	PUNCT
bibechana-25870	147	3	a.	a.	PROPN
bibechana-25870	147	4	dalke	dalke	PROPN
bibechana-25870	147	5	,	,	PUNCT
bibechana-25870	147	6	k.	k.	PROPN
bibechana-25870	147	7	schulten	schulten	PROPN
bibechana-25870	147	8	,	,	PUNCT
bibechana-25870	147	9	vmd	vmd	PROPN
bibechana-25870	147	10	—	—	PUNCT
bibechana-25870	147	11	visual	visual	ADJ
bibechana-25870	147	12	molecular	molecular	ADJ
bibechana-25870	147	13	dynamics	dynamic	NOUN
bibechana-25870	147	14	,	,	PUNCT
bibechana-25870	147	15	j.	j.	PROPN
bibechana-25870	147	16	mol	mol	PROPN
bibechana-25870	147	17	.	.	PUNCT
bibechana-25870	147	18	graphics	graphic	NOUN
bibechana-25870	147	19	14	14	NUM
bibechana-25870	147	20	(	(	PUNCT
bibechana-25870	147	21	1996	1996	NUM
bibechana-25870	147	22	)	)	PUNCT
bibechana-25870	147	23	33–38	33–38	NUM
bibechana-25870	147	24	.	.	PUNCT
bibechana-25870	148	1	doi.org/10.1016/0263-7855(96)00018-5	doi.org/10.1016/0263-7855(96)00018-5	X
bibechana-25870	149	1	[	[	X
bibechana-25870	149	2	15	15	NUM
bibechana-25870	149	3	]	]	X
bibechana-25870	149	4	a.	a.	NOUN
bibechana-25870	149	5	d.	d.	PROPN
bibechana-25870	149	6	mackerell	mackerell	PROPN
bibechana-25870	149	7	,	,	PUNCT
bibechana-25870	149	8	m.	m.	NOUN
bibechana-25870	149	9	feig	feig	PROPN
bibechana-25870	149	10	,	,	PUNCT
bibechana-25870	149	11	c.	c.	PROPN
bibechana-25870	149	12	l.	l.	PROPN
bibechana-25870	149	13	brooks	brooks	PROPN
bibechana-25870	149	14	,	,	PUNCT
bibechana-25870	149	15	extending	extend	VERB
bibechana-25870	149	16	the	the	DET
bibechana-25870	149	17	treatment	treatment	NOUN
bibechana-25870	149	18	of	of	ADP
bibechana-25870	149	19	backbone	backbone	NOUN
bibechana-25870	149	20	energetics	energetic	NOUN
bibechana-25870	149	21	in	in	ADP
bibechana-25870	149	22	protein	protein	NOUN
bibechana-25870	149	23	force	force	NOUN
bibechana-25870	149	24	fields	field	NOUN
bibechana-25870	149	25	:	:	PUNCT
bibechana-25870	149	26	limitations	limitation	NOUN
bibechana-25870	149	27	of	of	ADP
bibechana-25870	149	28	gas‐phase	gas‐phase	VERB
bibechana-25870	149	29	quantum	quantum	ADJ
bibechana-25870	149	30	mechanics	mechanic	NOUN
bibechana-25870	149	31	in	in	ADP
bibechana-25870	149	32	reproducing	reproduce	VERB
bibechana-25870	149	33	protein	protein	NOUN
bibechana-25870	149	34	conformational	conformational	ADJ
bibechana-25870	149	35	distributions	distribution	NOUN
bibechana-25870	149	36	in	in	ADP
bibechana-25870	149	37	molecular	molecular	ADJ
bibechana-25870	149	38	dynamics	dynamic	NOUN
bibechana-25870	149	39	simulations	simulation	NOUN
bibechana-25870	149	40	,	,	PUNCT
bibechana-25870	149	41	j.	j.	PROPN
bibechana-25870	149	42	comp	comp	PROPN
bibechana-25870	149	43	.	.	PUNCT
bibechana-25870	149	44	chem	chem	PROPN
bibechana-25870	149	45	.	.	PUNCT
bibechana-25870	150	1	25(2004	25(2004	NUM
bibechana-25870	150	2	)	)	PUNCT
bibechana-25870	150	3	1400	1400	NUM
bibechana-25870	150	4	-	-	SYM
bibechana-25870	150	5	1415	1415	NUM
bibechana-25870	150	6	.	.	PUNCT
bibechana-25870	151	1	doi.org/10.1002/jcc.20065	doi.org/10.1002/jcc.20065	NOUN
bibechana-25870	152	1	[	[	X
bibechana-25870	152	2	16	16	NUM
bibechana-25870	152	3	]	]	PUNCT
bibechana-25870	152	4	a.	a.	PROPN
bibechana-25870	152	5	d.	d.	PROPN
bibechana-25870	152	6	mackerell	mackerell	PROPN
bibechana-25870	152	7	,	,	PUNCT
bibechana-25870	152	8	d.	d.	PROPN
bibechana-25870	152	9	bashford	bashford	PROPN
bibechana-25870	152	10	,	,	PUNCT
bibechana-25870	152	11	m.	m.	NOUN
bibechana-25870	152	12	bellott	bellott	PROPN
bibechana-25870	152	13	,	,	PUNCT
bibechana-25870	152	14	r.	r.	PROPN
bibechana-25870	152	15	l.	l.	PROPN
bibechana-25870	152	16	dunbrack	dunbrack	PROPN
bibechana-25870	152	17	,	,	PUNCT
bibechana-25870	152	18	j.	j.	PROPN
bibechana-25870	152	19	d.	d.	PROPN
bibechana-25870	152	20	evanseck	evanseck	PROPN
bibechana-25870	152	21	,	,	PUNCT
bibechana-25870	152	22	m.	m.	NOUN
bibechana-25870	152	23	j.	j.	PROPN
bibechana-25870	152	24	field	field	PROPN
bibechana-25870	152	25	,	,	PUNCT
bibechana-25870	152	26	s.	s.	PROPN
bibechana-25870	152	27	fischer	fischer	PROPN
bibechana-25870	152	28	,	,	PUNCT
bibechana-25870	152	29	j.	j.	PROPN
bibechana-25870	152	30	gao	gao	PROPN
bibechana-25870	152	31	,	,	PUNCT
bibechana-25870	152	32	h.	h.	PROPN
bibechana-25870	152	33	guo	guo	PROPN
bibechana-25870	152	34	,	,	PUNCT
bibechana-25870	152	35	s.	s.	PROPN
bibechana-25870	152	36	ha	ha	PROPN
bibechana-25870	152	37	,	,	PUNCT
bibechana-25870	152	38	d.	d.	PROPN
bibechana-25870	152	39	joseph	joseph	PROPN
bibechana-25870	152	40	-	-	PUNCT
bibechana-25870	152	41	mccarthy	mccarthy	PROPN
bibechana-25870	152	42	,	,	PUNCT
bibechana-25870	152	43	all	all	DET
bibechana-25870	152	44	-	-	PUNCT
bibechana-25870	152	45	atom	atom	NOUN
bibechana-25870	152	46	empirical	empirical	ADJ
bibechana-25870	152	47	potential	potential	NOUN
bibechana-25870	152	48	for	for	ADP
bibechana-25870	152	49	molecular	molecular	ADJ
bibechana-25870	152	50	modeling	modeling	NOUN
bibechana-25870	152	51	and	and	CCONJ
bibechana-25870	152	52	dynamics	dynamic	NOUN
bibechana-25870	152	53	studies	study	NOUN
bibechana-25870	152	54	of	of	ADP
bibechana-25870	152	55	proteins	protein	NOUN
bibechana-25870	152	56	,	,	PUNCT
bibechana-25870	152	57	j.	j.	PROPN
bibechana-25870	152	58	phys	phys	PROPN
bibechana-25870	152	59	.	.	PUNCT
bibechana-25870	153	1	chem	chem	PROPN
bibechana-25870	153	2	.	.	PUNCT
bibechana-25870	154	1	b	b	X
bibechana-25870	154	2	102	102	NUM
bibechana-25870	154	3	(	(	PUNCT
bibechana-25870	154	4	1998	1998	NUM
bibechana-25870	154	5	)	)	PUNCT
bibechana-25870	154	6	3586–3616	3586–3616	NUM
bibechana-25870	154	7	.	.	PUNCT
bibechana-25870	155	1	doi.org/10.1021/jp973084f	doi.org/10.1021/jp973084f	NOUN
bibechana-25870	156	1	[	[	X
bibechana-25870	156	2	17]v	17]v	NUM
bibechana-25870	156	3	.	.	PUNCT
bibechana-25870	157	1	zoete	zoete	PROPN
bibechana-25870	157	2	,	,	PUNCT
bibechana-25870	157	3	m.	m.	NOUN
bibechana-25870	157	4	a.	a.	NOUN
bibechana-25870	157	5	cuendet	cuendet	PROPN
bibechana-25870	157	6	,	,	PUNCT
bibechana-25870	157	7	a.	a.	NOUN
bibechana-25870	157	8	grosdidier	grosdidier	NOUN
bibechana-25870	157	9	,	,	PUNCT
bibechana-25870	157	10	o.	o.	PROPN
bibechana-25870	157	11	michielin	michielin	PROPN
bibechana-25870	157	12	,	,	PUNCT
bibechana-25870	157	13	swissparam	swissparam	PROPN
bibechana-25870	157	14	:	:	PUNCT
bibechana-25870	157	15	a	a	DET
bibechana-25870	157	16	fast	fast	ADJ
bibechana-25870	157	17	force	force	NOUN
bibechana-25870	157	18	field	field	NOUN
bibechana-25870	157	19	generation	generation	NOUN
bibechana-25870	157	20	tool	tool	NOUN
bibechana-25870	157	21	for	for	ADP
bibechana-25870	157	22	small	small	ADJ
bibechana-25870	157	23	organic	organic	ADJ
bibechana-25870	157	24	molecules	molecule	NOUN
bibechana-25870	157	25	,	,	PUNCT
bibechana-25870	157	26	j.	j.	PROPN
bibechana-25870	157	27	comp	comp	PROPN
bibechana-25870	157	28	.	.	PUNCT
bibechana-25870	158	1	chem	chem	PROPN
bibechana-25870	158	2	.	.	PUNCT
bibechana-25870	159	1	32	32	NUM
bibechana-25870	159	2	(	(	PUNCT
bibechana-25870	159	3	2011	2011	NUM
bibechana-25870	159	4	)	)	PUNCT
bibechana-25870	159	5	2359	2359	NUM
bibechana-25870	159	6	-	-	SYM
bibechana-25870	159	7	2368	2368	NUM
bibechana-25870	159	8	.	.	PUNCT
bibechana-25870	160	1	doi.org/	doi.org/	ADP
bibechana-25870	160	2	10.1002	10.1002	NUM
bibechana-25870	160	3	/	/	SYM
bibechana-25870	160	4	jcc.21816	jcc.21816	PROPN
bibechana-25870	161	1	[	[	X
bibechana-25870	161	2	18	18	NUM
bibechana-25870	161	3	]	]	X
bibechana-25870	161	4	l.	l.	PROPN
bibechana-25870	161	5	verlet	verlet	PROPN
bibechana-25870	161	6	,	,	PUNCT
bibechana-25870	161	7	computer	computer	NOUN
bibechana-25870	161	8	"	"	PUNCT
bibechana-25870	161	9	experiments	experiment	NOUN
bibechana-25870	161	10	"	"	PUNCT
bibechana-25870	161	11	on	on	ADP
bibechana-25870	161	12	classical	classical	ADJ
bibechana-25870	161	13	fluids	fluid	NOUN
bibechana-25870	161	14	.	.	PUNCT
bibechana-25870	162	1	i.	i.	PROPN
bibechana-25870	162	2	thermodynamical	thermodynamical	ADJ
bibechana-25870	162	3	properties	property	NOUN
bibechana-25870	162	4	of	of	ADP
bibechana-25870	162	5	lennardjones	lennardjone	NOUN
bibechana-25870	162	6	molecules	molecule	NOUN
bibechana-25870	162	7	,	,	PUNCT
bibechana-25870	162	8	phy	phy	PROPN
bibechana-25870	162	9	.	.	PUNCT
bibechana-25870	162	10	rev	rev	PROPN
bibechana-25870	162	11	.	.	PROPN
bibechana-25870	162	12	159	159	NUM
bibechana-25870	162	13	(	(	PUNCT
bibechana-25870	162	14	1967	1967	NUM
bibechana-25870	162	15	)	)	PUNCT
bibechana-25870	162	16	98	98	NUM
bibechana-25870	162	17	.	.	PUNCT
bibechana-25870	163	1	doi.org/10.1103/physrev.159.98	doi.org/10.1103/physrev.159.98	PROPN
bibechana-25870	164	1	[	[	X
bibechana-25870	164	2	19	19	NUM
bibechana-25870	164	3	]	]	PUNCT
bibechana-25870	164	4	j.	j.	PROPN
bibechana-25870	164	5	j.	j.	PROPN
bibechana-25870	164	6	booth	booth	PROPN
bibechana-25870	164	7	,	,	PUNCT
bibechana-25870	164	8	d.	d.	PROPN
bibechana-25870	164	9	v.	v.	PROPN
bibechana-25870	164	10	shalashilin	shalashilin	PROPN
bibechana-25870	164	11	,	,	PUNCT
bibechana-25870	164	12	fully	fully	ADV
bibechana-25870	164	13	atomistic	atomistic	ADJ
bibechana-25870	164	14	simulations	simulation	NOUN
bibechana-25870	164	15	of	of	ADP
bibechana-25870	164	16	protein	protein	NOUN
bibechana-25870	164	17	unfolding	unfold	VERB
bibechana-25870	164	18	in	in	ADP
bibechana-25870	164	19	low	low	ADJ
bibechana-25870	164	20	speed	speed	NOUN
bibechana-25870	164	21	atomic	atomic	ADJ
bibechana-25870	164	22	force	force	NOUN
bibechana-25870	164	23	microscope	microscope	NOUN
bibechana-25870	164	24	and	and	CCONJ
bibechana-25870	164	25	force	force	VERB
bibechana-25870	164	26	clamp	clamp	NOUN
bibechana-25870	164	27	experiments	experiment	NOUN
bibechana-25870	164	28	with	with	ADP
bibechana-25870	164	29	the	the	DET
bibechana-25870	164	30	help	help	NOUN
bibechana-25870	164	31	of	of	ADP
bibechana-25870	164	32	boxed	box	VERB
bibechana-25870	164	33	molecular	molecular	ADJ
bibechana-25870	164	34	dynamics	dynamic	NOUN
bibechana-25870	164	35	,	,	PUNCT
bibechana-25870	164	36	j.	j.	PROPN
bibechana-25870	164	37	phys	phys	PROPN
bibechana-25870	164	38	.	.	PUNCT
bibechana-25870	165	1	chem	chem	PROPN
bibechana-25870	165	2	.	.	PUNCT
bibechana-25870	166	1	b	b	X
bibechana-25870	166	2	120(2016	120(2016	NUM
bibechana-25870	166	3	)	)	PUNCT
bibechana-25870	166	4	700	700	NUM
bibechana-25870	166	5	-	-	NUM
bibechana-25870	166	6	708	708	NUM
bibechana-25870	166	7	.	.	PUNCT
bibechana-25870	167	1	doi.org/10.1021/acs.jpcb.5b11519	doi.org/10.1021/acs.jpcb.5b11519	NOUN
bibechana-25870	167	2	[	[	PUNCT
bibechana-25870	167	3	20	20	NUM
bibechana-25870	167	4	]	]	PUNCT
bibechana-25870	167	5	d.	d.	PROPN
bibechana-25870	167	6	kosztin	kosztin	PROPN
bibechana-25870	167	7	,	,	PUNCT
bibechana-25870	167	8	s.	s.	PROPN
bibechana-25870	167	9	izrailev	izrailev	PROPN
bibechana-25870	167	10	,	,	PUNCT
bibechana-25870	167	11	k.	k.	PROPN
bibechana-25870	167	12	schulten	schulten	PROPN
bibechana-25870	167	13	,	,	PUNCT
bibechana-25870	167	14	unbinding	unbinding	NOUN
bibechana-25870	167	15	of	of	ADP
bibechana-25870	167	16	retinoic	retinoic	PROPN
bibechana-25870	167	17	acid	acid	NOUN
bibechana-25870	167	18	from	from	ADP
bibechana-25870	167	19	its	its	PRON
bibechana-25870	167	20	receptor	receptor	NOUN
bibechana-25870	167	21	studied	study	VERB
bibechana-25870	167	22	by	by	ADP
bibechana-25870	167	23	steered	steered	ADJ
bibechana-25870	167	24	molecular	molecular	ADJ
bibechana-25870	167	25	dynamics	dynamic	NOUN
bibechana-25870	167	26	,	,	PUNCT
bibechana-25870	167	27	biophys	biophy	NOUN
bibechana-25870	167	28	.	.	PUNCT
bibechana-25870	168	1	j.	j.	PROPN
bibechana-25870	168	2	76(1999	76(1999	PROPN
bibechana-25870	168	3	)	)	PUNCT
bibechana-25870	168	4	188	188	NUM
bibechana-25870	168	5	-	-	SYM
bibechana-25870	168	6	197	197	NUM
bibechana-25870	168	7	.	.	PUNCT
bibechana-25870	169	1	doi.org/10.1016/s0006-3495(99)77188-2	doi.org/10.1016/s0006-3495(99)77188-2	NOUN
bibechana-25870	169	2	[	[	X
bibechana-25870	169	3	21	21	NUM
bibechana-25870	169	4	]	]	X
bibechana-25870	169	5	l.	l.	PROPN
bibechana-25870	169	6	martínez	martínez	PROPN
bibechana-25870	169	7	,	,	PUNCT
bibechana-25870	169	8	p.	p.	PROPN
bibechana-25870	169	9	webb	webb	PROPN
bibechana-25870	169	10	,	,	PUNCT
bibechana-25870	169	11	i.	i.	PROPN
bibechana-25870	169	12	polikarpov	polikarpov	PROPN
bibechana-25870	169	13	,	,	PUNCT
bibechana-25870	169	14	m.	m.	NOUN
bibechana-25870	169	15	s.	s.	PROPN
bibechana-25870	169	16	skaf	skaf	PROPN
bibechana-25870	169	17	,	,	PUNCT
bibechana-25870	169	18	molecular	molecular	ADJ
bibechana-25870	169	19	dynamics	dynamic	NOUN
bibechana-25870	169	20	simulations	simulation	NOUN
bibechana-25870	169	21	of	of	ADP
bibechana-25870	169	22	ligand	ligand	ADJ
bibechana-25870	169	23	dissociation	dissociation	NOUN
bibechana-25870	169	24	from	from	ADP
bibechana-25870	169	25	thyroid	thyroid	NOUN
bibechana-25870	169	26	hormone	hormone	NOUN
bibechana-25870	169	27	receptors	receptor	NOUN
bibechana-25870	169	28	:	:	PUNCT
bibechana-25870	169	29	evidence	evidence	NOUN
bibechana-25870	169	30	of	of	ADP
bibechana-25870	169	31	the	the	DET
bibechana-25870	169	32	likeliest	likeli	ADJ
bibechana-25870	169	33	escape	escape	NOUN
bibechana-25870	169	34	pathway	pathway	NOUN
bibechana-25870	169	35	and	and	CCONJ
bibechana-25870	169	36	its	its	PRON
bibechana-25870	169	37	implications	implication	NOUN
bibechana-25870	169	38	for	for	ADP
bibechana-25870	169	39	the	the	DET
bibechana-25870	169	40	design	design	NOUN
bibechana-25870	169	41	of	of	ADP
bibechana-25870	169	42	novel	novel	ADJ
bibechana-25870	169	43	ligands	ligand	NOUN
bibechana-25870	169	44	,	,	PUNCT
bibechana-25870	169	45	j.	j.	PROPN
bibechana-25870	169	46	med	med	PROPN
bibechana-25870	169	47	.	.	PROPN
bibechana-25870	169	48	chem	chem	PROPN
bibechana-25870	169	49	.	.	PUNCT
bibechana-25870	170	1	49(2006	49(2006	NUM
bibechana-25870	170	2	)	)	PUNCT
bibechana-25870	170	3	23	23	NUM
bibechana-25870	170	4	-	-	SYM
bibechana-25870	170	5	26	26	NUM
bibechana-25870	170	6	.	.	PUNCT
bibechana-25870	171	1	doi.org/10.1021/jm050805n	doi.org/10.1021/jm050805n	PUNCT
bibechana-25870	172	1	[	[	X
bibechana-25870	172	2	22	22	NUM
bibechana-25870	172	3	]	]	PUNCT
bibechana-25870	172	4	j.	j.	PROPN
bibechana-25870	172	5	l.	l.	PROPN
bibechana-25870	172	6	zhang	zhang	PROPN
bibechana-25870	172	7	,	,	PUNCT
bibechana-25870	172	8	q.	q.	PROPN
bibechana-25870	172	9	c.	c.	PROPN
bibechana-25870	172	10	zheng	zheng	PROPN
bibechana-25870	172	11	,	,	PUNCT
bibechana-25870	172	12	h.	h.	PROPN
bibechana-25870	172	13	x.	x.	PROPN
bibechana-25870	172	14	zhang	zhang	PROPN
bibechana-25870	172	15	,	,	PUNCT
bibechana-25870	172	16	unbinding	unbind	VERB
bibechana-25870	172	17	of	of	ADP
bibechana-25870	172	18	glucose	glucose	NOUN
bibechana-25870	172	19	from	from	ADP
bibechana-25870	172	20	human	human	ADJ
bibechana-25870	172	21	pulmonary	pulmonary	ADJ
bibechana-25870	172	22	surfactant	surfactant	NOUN
bibechana-25870	172	23	protein	protein	NOUN
bibechana-25870	173	1	d	d	PROPN
bibechana-25870	173	2	studied	study	VERB
bibechana-25870	173	3	by	by	ADP
bibechana-25870	173	4	steered	steer	VERB
bibechana-25870	173	5	molecular	molecular	ADJ
bibechana-25870	173	6	dynamics	dynamic	NOUN
bibechana-25870	173	7	simulations	simulation	NOUN
bibechana-25870	173	8	,	,	PUNCT
bibechana-25870	173	9	chem	chem	NOUN
bibechana-25870	173	10	.	.	PUNCT
bibechana-25870	174	1	phys	phy	NOUN
bibechana-25870	174	2	.	.	PUNCT
bibechana-25870	175	1	lett	lett	PROPN
bibechana-25870	175	2	.	.	PUNCT
bibechana-25870	176	1	484(2010	484(2010	NOUN
bibechana-25870	176	2	)	)	PUNCT
bibechana-25870	176	3	338	338	NUM
bibechana-25870	176	4	-	-	SYM
bibechana-25870	176	5	343	343	NUM
bibechana-25870	176	6	.	.	PUNCT
bibechana-25870	177	1	doi.org/10.1016/j.cplett.2009.12.022	doi.org/10.1016/j.cplett.2009.12.022	NOUN
bibechana-25870	177	2	https://doi.org/10.1007/s10867-018-9518-3	https://doi.org/10.1007/s10867-018-9518-3	NUM
bibechana-25870	178	1	https://doi.org/10.3934/biophy.2018.4.245	https://doi.org/10.3934/biophy.2018.4.245	PROPN
bibechana-25870	178	2	https://doi.org/10.3126/bibechana.v16i0.21109	https://doi.org/10.3126/bibechana.v16i0.21109	VERB
bibechana-25870	178	3	https://doi.org/10.1021/acs.jpcb.5b11519	https://doi.org/10.1021/acs.jpcb.5b11519	X
bibechana-25870	178	4	https://doi.org/10.1002/pro.3117	https://doi.org/10.1002/pro.3117	PROPN
bibechana-25870	178	5	https://doi.org/10.1016/j.jmb.2016.09.006	https://doi.org/10.1016/j.jmb.2016.09.006	ADJ
bibechana-25870	178	6	https://doi.org/10.1073/pnas.0905796107	https://doi.org/10.1073/pnas.0905796107	PART
bibechana-25870	178	7	https://doi.org/10.1021/jp803403c	https://doi.org/10.1021/jp803403c	PROPN
bibechana-25870	178	8	https://doi.org/10.1006/jcph.1999.6218	https://doi.org/10.1006/jcph.1999.6218	PROPN
bibechana-25870	178	9	https://doi.org/10.1021/acs.jpcb.5b11519	https://doi.org/10.1021/acs.jpcb.5b11519	NOUN
bibechana-25870	178	10	https://doi.org/10.1016/s0006-3495(99)77188-2	https://doi.org/10.1016/s0006-3495(99)77188-2	NOUN
bibechana-25870	178	11	https://doi.org/10.1021/jm050805n	https://doi.org/10.1021/jm050805n	PROPN